1	Anti-Ro(SSA)	anti-ro(ssa)	JJ	JJ	_	2	amod	_	_
2	autoantibodies	autoantibody	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	10	case	_	_
6	T	t	NN	NN	_	10	compound	_	_
7	cell	cell	NN	NN	_	10	compound	_	_
8	receptor	receptor	NN	NN	_	10	compound	_	_
9	beta	beta	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	systemic	systemic	JJ	JJ	_	15	amod	_	_
13	lupus	lupus	NN	NN	_	15	compound	_	_
14	erythematosus	erythematosus	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Several	several	JJ	JJ	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	heterogeneous	heterogeneous	JJ	JJ	_	6	amod	_	_
5	clinical	clinical	JJ	JJ	_	4	dep	_	_
6	manifestations	manifestation	NNS	NNS	_	1	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	systemic	systemic	JJ	JJ	_	10	amod	_	_
9	lupus	lupus	NN	NN	_	10	compound	_	_
10	erythematosus	erythematosus	NN	NN	_	6	nmod	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	autoantibodies	autoantibody	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Associations	association	NNS	NNS	_	17	nsubjpass	_	_
2	between	between	IN	IN	_	6	case	_	_
3	HLA	hla	NN	NN	_	6	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	antigens	antigen	NNS	NNS	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	autoantibodies	autoantibody	NNS	NNS	_	6	conj	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	ribonucleoproteins	ribonucleoprotein	NNS	NNS	_	8	nmod	_	_
12	Ro(SSA)	ro(ssa)	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	La(SSB)	la(ssb)	NN	NN	_	12	conj	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	reported	report	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	patients	patient	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	HLA	hla	NN	NN	_	5	compound	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	molecules	molecule	NNS	NNS	_	6	nsubj	_	_
6	present	present	VBP	VBP	_	18	advcl	_	_
7	antigen	antigen	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TCRs	tcr	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	searched	search	VBN	VBN	_	0	root	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	TCR	tcr	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	associated	associate	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	production	production	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	anti-Ro(SSA)	anti-ro(ssa)	JJ	JJ	_	29	amod	_	_
29	antibodies	antibody	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	pair	pair	NN	NN	_	36	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	restriction	restriction	NN	NN	_	7	compound	_	_
5	fragment	fragment	NN	NN	_	7	compound	_	_
6	length	length	NN	NN	_	7	compound	_	_
7	polymorphisms	polymorphism	NNS	NNS	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RFLPs	rflp	NNS	NNS	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	2	punct	_	_
12	one	one	CD	CD	_	15	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	12	nmod	_	_
15	hybridizes	hybridize	VBZ	VBZ	_	2	acl:relcl	_	_
16	to	to	TO	TO	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	TCR	tcr	NN	NN	_	22	compound	_	_
19	constant	constant	JJ	JJ	_	22	amod	_	_
20	region	region	NN	NN	_	22	compound	_	_
21	C	c	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	15	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	other	other	JJ	JJ	_	15	conj	_	_
27	to	to	TO	TO	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	C	c	NN	NN	_	32	compound	_	_
30	beta	beta	NN	NN	_	32	compound	_	_
31	2	2	CD	CD	_	32	nummod	_	_
32	gene	gene	NN	NN	_	26	nmod	_	_
33	,	,	,	,	_	2	punct	_	_
34	has	have	VBZ	VBZ	_	36	aux	_	_
35	been	be	VBN	VBN	_	36	auxpass	_	_
36	identified	identify	VBN	VBN	_	0	root	_	_
37	,	,	,	,	_	36	punct	_	_
38	suggesting	suggest	VBG	VBG	_	36	advcl	_	_
39	these	these	DT	DT	_	43	nsubj	_	_
40	may	may	MD	MD	_	43	aux	_	_
41	be	be	VB	VB	_	43	cop	_	_
42	genotypic	genotypic	JJ	JJ	_	43	amod	_	_
43	markers	marker	NNS	NNS	_	38	ccomp	_	_
44	for	for	IN	IN	_	47	case	_	_
45	an	a	DT	DT	_	47	det	_	_
46	extended	extend	VBN	VBN	_	47	amod	_	_
47	region	region	NN	NN	_	43	nmod	_	_
48	of	of	IN	IN	_	52	case	_	_
49	the	the	DT	DT	_	52	det	_	_
50	TCR	tcr	NN	NN	_	52	compound	_	_
51	beta	beta	NN	NN	_	52	compound	_	_
52	locus	locus	NN	NN	_	47	nmod	_	_
53	.	.	.	.	_	36	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	RFLP	rflp	NN	NN	_	3	compound	_	_
3	pair	pair	NN	NN	_	4	nsubj	_	_
4	occurs	occur	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	76	76	CD	CD	_	7	nummod	_	_
7	%	%	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	Ro(SSA)	ro(ssa)	NN	NN	_	12	compound	_	_
12	precipitins	precipitin	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	84	84	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	7	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	anti-Ro(SSA)-positive	anti-ro(ssa)-positive	JJ	JJ	_	18	amod	_	_
18	patients	patient	NNS	NNS	_	15	nmod	_	_
19	lacking	lack	VBG	VBG	_	18	acl	_	_
20	La(SSB)	la(ssb)	NN	NN	_	19	dobj	_	_
21	precipitins	precipitin	NNS	NNS	_	20	dep	_	_
22	,	,	,	,	_	7	punct	_	_
23	but	but	CC	CC	_	7	cc	_	_
24	only	only	RB	RB	_	25	advmod	_	_
25	41	41	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	7	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	patients	patient	NNS	NNS	_	26	nmod	_	_
30	lacking	lack	VBG	VBG	_	29	acl	_	_
31	both	both	DT	DT	_	32	dep	_	_
32	precipitins	precipitin	NNS	NNS	_	30	dobj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	P	p	NN	NN	_	29	dep	_	_
35	=	=	JJ	JJ	_	34	amod	_	_
36	0.0004	0.0004	CD	CD	_	35	dep	_	_
37	)	)	-RRB-	-RRB-	_	34	punct	_	_
38	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	disproportionate	disproportionate	JJ	JJ	_	3	amod	_	_
3	occurrence	occurrence	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subset	subset	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	lupus	lupus	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	indicates	indicate	VBZ	VBZ	_	0	root	_	_
11	that	that	IN	IN	_	18	mark	_	_
12	these	these	DT	DT	_	13	det	_	_
13	RFLPs	rflp	NNS	NNS	_	18	nsubj	_	_
14	are	be	VBP	VBP	_	18	cop	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	disease	disease	NN	NN	_	18	compound	_	_
17	susceptibility	susceptibility	NN	NN	_	18	compound	_	_
18	markers	marker	NNS	NNS	_	10	ccomp	_	_
19	,	,	,	,	_	18	punct	_	_
20	but	but	CC	CC	_	18	cc	_	_
21	rather	rather	RB	RB	_	24	advmod	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	important	important	JJ	JJ	_	24	amod	_	_
24	markers	marker	NNS	NNS	_	18	conj	_	_
25	for	for	IN	IN	_	27	case	_	_
26	TCR	tcr	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	whose	whose	WP$	WP$	_	29	nmod:poss	_	_
29	products	product	NNS	NNS	_	31	nsubjpass	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	involved	involve	VBN	VBN	_	27	acl:relcl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	production	production	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	anti-Ro(SSA)	anti-ro(ssa)	JJ	JJ	_	37	amod	_	_
37	antibodies	antibody	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	majority	majority	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	who	who	WP	WP	_	6	nsubj	_	_
6	have	have	VBP	VBP	_	2	acl:relcl	_	_
7	these	these	DT	DT	_	8	det	_	_
8	RFLPs	rflp	NNS	NNS	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	HLA	hla	NN	NN	_	13	compound	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	antigens	antigen	NNS	NNS	_	8	conj	_	_
14	previously	previously	RB	RB	_	15	advmod	_	_
15	associated	associate	VBN	VBN	_	8	acl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	anti-Ro(SSA)	anti-ro(ssa)	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	15	nmod	_	_
20	make	make	VBP	VBP	_	0	root	_	_
21	this	this	DT	DT	_	22	det	_	_
22	antibody	antibody	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	20	punct	_	_
24	suggesting	suggest	VBG	VBG	_	20	advcl	_	_
25	that	that	IN	IN	_	32	mark	_	_
26	interactions	interaction	NNS	NNS	_	32	nsubj	_	_
27	between	between	IN	IN	_	28	case	_	_
28	products	product	NNS	NNS	_	26	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	these	these	DT	DT	_	31	det	_	_
31	loci	locus	NNS	NNS	_	28	nmod	_	_
32	occur	occur	VBP	VBP	_	24	ccomp	_	_
33	in	in	IN	IN	_	34	case	_	_
34	response	response	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	36	case	_	_
36	Ro(SSA)	ro(ssa)	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	20	punct	_	_

1	Reactivity	reactivity	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
4	to	to	TO	TO	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	progesterone	progesterone	NN	NN	_	9	compound	_	_
7	receptor-specific	receptor-specific	JJ	JJ	_	9	amod	_	_
8	monoclonal	monoclonal	JJ	JJ	_	9	amod	_	_
9	antibody	antibody	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	present	present	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	reactivity	reactivity	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	pregnancy	pregnancy	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	11	cc	_	_
15	nonpregnancy	nonpregnancy	JJ	JJ	_	16	amod	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	11	conj	_	_
17	,	,	,	,	_	5	punct	_	_
18	with	with	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	progesterone	progesterone	NN	NN	_	23	compound	_	_
21	receptor-specific	receptor-specific	JJ	JJ	_	23	amod	_	_
22	monoclonal	monoclonal	JJ	JJ	_	23	amod	_	_
23	antibody	antibody	NN	NN	_	5	nmod	_	_
24	mPRI	mpri	NN	NN	_	23	dep	_	_
25	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	an	a	DT	DT	_	6	det	_	_
3	avidin-biotin	avidin-biotin	JJ	JJ	_	4	amod	_	_
4	peroxidase	peroxidase	NN	NN	_	6	compound	_	_
5	detection	detection	NN	NN	_	6	compound	_	_
6	system	system	NN	NN	_	1	dobj	_	_
7	,	,	,	,	_	1	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	found	find	VBD	VBD	_	1	parataxis	_	_
10	a	a	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	staining	staining	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	14.6	14.6	CD	CD	_	17	nummod	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	3.7	3.7	CD	CD	_	14	conj	_	_
17	%	%	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	mean	mean	NN	NN	_	17	dep	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	SEM	sem	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	N	n	NN	NN	_	19	appos	_	_
24	=	=	JJ	JJ	_	23	amod	_	_
25	27	27	CD	CD	_	24	dep	_	_
26	)	)	-RRB-	-RRB-	_	19	punct	_	_
27	of	of	IN	IN	_	29	case	_	_
28	pregnancy	pregnancy	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
30	,	,	,	,	_	9	punct	_	_
31	while	while	IN	IN	_	49	mark	_	_
32	only	only	RB	RB	_	33	advmod	_	_
33	0.47	0.47	CD	CD	_	36	nummod	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	0.33	0.33	CD	CD	_	33	conj	_	_
36	%	%	NN	NN	_	49	nsubj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	mean	mean	NN	NN	_	36	dep	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	SEM	sem	NN	NN	_	38	conj	_	_
41	,	,	,	,	_	38	punct	_	_
42	N	n	NN	NN	_	38	appos	_	_
43	=	=	JJ	JJ	_	42	amod	_	_
44	15	15	CD	CD	_	43	dep	_	_
45	)	)	-RRB-	-RRB-	_	38	punct	_	_
46	of	of	IN	IN	_	48	case	_	_
47	nonpregnancy	nonpregnancy	NN	NN	_	48	compound	_	_
48	lymphocytes	lymphocyte	NNS	NNS	_	36	nmod	_	_
49	reacted	react	VBD	VBD	_	9	advcl	_	_
50	with	with	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	antibody	antibody	NN	NN	_	49	nmod	_	_
53	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	receptor-bearing	receptor-bearing	JJ	JJ	_	5	amod	_	_
5	subset	subset	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	CD8+	cd8+	JJ	JJ	_	12	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CD4+	cd4+	JJ	JJ	_	7	conj	_	_
10	cells	cell	NNS	NNS	_	7	dep	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	depleted	deplete	VBN	VBN	_	2	parataxis	_	_
13	by	by	IN	IN	_	15	case	_	_
14	complement-dependent	complement-dependent	JJ	JJ	_	15	amod	_	_
15	lysis	lysis	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Depletion	depletion	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CD8+	cd8+	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	12	case	_	_
8	62	62	CD	CD	_	11	dep	_	_
9	+/-	+/-	CC	CC	_	8	cc	_	_
10	18	18	CD	CD	_	8	conj	_	_
11	%	%	NN	NN	_	12	dep	_	_
12	loss	loss	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	progesterone	progesterone	NN	NN	_	16	compound	_	_
15	receptor-bearing	receptor-bearing	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	while	while	IN	IN	_	23	mark	_	_
19	depletion	depletion	NN	NN	_	23	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	resulted	result	VBD	VBD	_	6	advcl	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	twofold	twofold	JJ	JJ	_	27	amod	_	_
27	increase	increase	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	number	number	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	positively	positively	RB	RB	_	33	advmod	_	_
33	staining	stain	VBG	VBG	_	34	amod	_	_
34	lymphocytes	lymphocyte	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	nonpregnancy	nonpregnancy	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
4	a	a	DT	DT	_	7	det	_	_
5	3-day	3-day	JJ	JJ	_	7	amod	_	_
6	PHA	pha	NN	NN	_	7	compound	_	_
7	treatment	treatment	NN	NN	_	15	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	as	as	RB	RB	_	7	cc	_	_
10	well	well	RB	RB	_	9	mwe	_	_
11	as	as	IN	IN	_	9	mwe	_	_
12	allogeneic	allogeneic	JJ	JJ	_	13	amod	_	_
13	stimulation	stimulation	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	significant	significant	JJ	JJ	_	19	amod	_	_
19	increase	increase	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	number	number	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	receptor-containing	receptor-containing	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	pregnancy	pregnancy	NN	NN	_	12	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	nonpregnancy	nonpregnancy	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	conj	_	_
12	contain	contain	VBP	VBP	_	3	ccomp	_	_
13	progesterone	progesterone	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	structures	structure	NNS	NNS	_	12	dobj	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	these	these	DT	DT	_	21	nsubj	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	inducible	inducible	JJ	JJ	_	12	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	mitogenic	mitogenic	JJ	JJ	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	alloantigenic	alloantigenic	JJ	JJ	_	23	conj	_	_
26	stimuli	stimulus	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	distinct	distinct	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	0	root	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	bind	bind	VBP	VBP	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	6	dobj	_	_
10	microE5/kappa	microe5/kappa	NN	NN	_	12	compound	_	_
11	2	2	CD	CD	_	12	nummod	_	_
12	motif	motif	NN	NN	_	9	dep	_	_
13	.	.	.	.	_	4	punct	_	_

1	Activity	activity	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	1	nmod	_	_
5	heavy	heavy	JJ	JJ	_	4	amod	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	kappa	kappa	NN	NN	_	4	conj	_	_
8	light	light	JJ	JJ	_	7	amod	_	_
9	chain	chain	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	enhancers	enhancer	NNS	NNS	_	4	dep	_	_
12	depends	depend	VBZ	VBZ	_	0	root	_	_
13	on	on	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	complex	complex	JJ	JJ	_	16	amod	_	_
16	interplay	interplay	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	ubiquitous	ubiquitous	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	developmentally	developmentally	RB	RB	_	18	advmod	_	_
21	regulated	regulate	VBN	VBN	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	complementary	complementary	JJ	JJ	_	3	amod	_	_
3	DNAs	dna	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	isolated	isolate	VBN	VBN	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	encode	encode	VBP	VBP	_	5	dep	_	_
8	proteins	protein	NNS	NNS	_	7	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	denoted	denote	VBN	VBN	_	8	acl	_	_
11	ITF-1	itf-1	NN	NN	_	10	xcomp	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	ITF-2	itf-2	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	8	punct	_	_
15	that	that	WDT	WDT	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	8	acl:relcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	variety	variety	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	types	type	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	bind	bind	VBP	VBP	_	17	conj	_	_
26	the	the	DT	DT	_	29	det	_	_
27	microE5/kappa	microe5/kappa	NN	NN	_	29	compound	_	_
28	2	2	CD	CD	_	29	nummod	_	_
29	motif	motif	NN	NN	_	25	dobj	_	_
30	found	find	VBN	VBN	_	29	acl	_	_
31	in	in	IN	IN	_	33	case	_	_
32	both	both	CC	CC	_	33	cc:preconj	_	_
33	heavy	heavy	JJ	JJ	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	kappa	kappa	NN	NN	_	33	conj	_	_
36	light	light	JJ	JJ	_	35	amod	_	_
37	chain	chain	NN	NN	_	38	compound	_	_
38	enhancers	enhancer	NNS	NNS	_	33	dep	_	_
39	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	complementary	complementary	JJ	JJ	_	3	amod	_	_
3	DNAs	dna	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	the	the	DT	DT	_	6	det	_	_
6	products	product	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	distinct	distinct	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	yet	yet	CC	CC	_	6	cc	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	ITF-1	itf-1	NN	NN	_	17	nsubj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ITF-2	itf-2	NN	NN	_	13	conj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	structurally	structurally	RB	RB	_	6	conj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	functionally	functionally	RB	RB	_	17	conj	_	_
20	similar	similar	JJ	JJ	_	17	dep	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	interact	interact	VBP	VBP	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	one	one	CD	CD	_	4	nmod	_	_
7	another	another	DT	DT	_	6	dep	_	_
8	through	through	IN	IN	_	12	case	_	_
9	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
10	putative	putative	JJ	JJ	_	12	amod	_	_
11	helix-loop-helix	helix-loop-helix	JJ	JJ	_	12	amod	_	_
12	motifs	motif	NNS	NNS	_	4	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	each	each	DT	DT	_	15	nsubj	_	_
15	possesses	possess	VBZ	VBZ	_	4	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	15	dobj	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	dictates	dictate	VBZ	VBZ	_	15	dep	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	human	human	JJ	JJ	_	10	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	10	compound	_	_
6	virus	virus	NN	NN	_	10	compound	_	_
7	type	type	NN	NN	_	10	compound	_	_
8	1	1	CD	CD	_	10	nummod	_	_
9	enhancer-binding	enhancer-binding	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	1	nmod	_	_
11	from	from	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	10	nmod	_	_
16	Jurkat	jurkat	NN	NN	_	15	dep	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	transcription	transcription	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	2	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HIV-1	hiv-1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	under	under	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	control	control	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	bind	bind	VBP	VBP	_	19	acl:relcl	_	_
22	to	to	TO	TO	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	viral	viral	JJ	JJ	_	27	amod	_	_
25	long	long	JJ	JJ	_	27	amod	_	_
26	terminal	terminal	JJ	JJ	_	27	amod	_	_
27	repeat	repeat	NN	NN	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	LTR	ltr	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	16	punct	_	_

1	Among	among	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	protein-binding	protein-binding	JJ	JJ	_	4	amod	_	_
4	regions	region	NNS	NNS	_	12	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	LTR	ltr	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription-enhancer	transcription-enhancer	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	at	at	IN	IN	_	5	case	_	_
5	least	least	JJS	JJS	_	6	nmod:npmod	_	_
6	one	one	CD	CD	_	7	nummod	_	_
7	inducible	inducible	JJ	JJ	_	19	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	C1	c1	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	one	one	CD	CD	_	17	nummod	_	_
13	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
14	,	,	,	,	_	17	punct	_	_
15	C2	c2	NN	NN	_	17	dep	_	_
16	,	,	,	,	_	17	punct	_	_
17	protein	protein	NN	NN	_	7	conj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	bind	bind	VB	VB	_	2	ccomp	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	enhancer	enhancer	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	Jurkat	jurkat	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	differ	differ	VBP	VBP	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
7	surface	surface	NN	NN	_	8	compound	_	_
8	charge	charge	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	since	since	IN	IN	_	13	mark	_	_
11	they	they	PRP	PRP	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	separable	separable	JJ	JJ	_	4	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	anion-exchange	anion-exchange	JJ	JJ	_	16	amod	_	_
16	chromatography	chromatography	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Bivalent	bivalent	JJ	JJ	_	2	amod	_	_
2	cations	cation	NNS	NNS	_	9	nsubj	_	_
3	such	such	JJ	JJ	_	5	case	_	_
4	as	as	IN	IN	_	3	mwe	_	_
5	Mg2+	mg2+	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Zn2+	zn2+	NN	NN	_	5	conj	_	_
8	differentially	differentially	RB	RB	_	9	advmod	_	_
9	affect	affect	VBP	VBP	_	0	root	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	binding	binding	NN	NN	_	9	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	oligonucleotides	oligonucleotide	NNS	NNS	_	11	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	contain	contain	VBP	VBP	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HIV-enhancer	hiv-enhancer	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	C1	c1	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	C2	c2	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	conj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	bind	bind	VBP	VBP	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	similar	similar	JJ	JJ	_	11	amod	_	_
11	sequence	sequence	NN	NN	_	7	nmod	_	_
12	found	find	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	interleukin-2-receptor	interleukin-2-receptor	NN	NN	_	17	compound	_	_
16	alpha-subunit	alpha-subunit	NN	NN	_	17	compound	_	_
17	enhancer	enhancer	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	inducible	inducible	JJ	JJ	_	4	amod	_	_
3	C1	c1	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	partially	partially	RB	RB	_	7	advmod	_	_
7	purified	purify	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	chromatographic	chromatographic	JJ	JJ	_	11	amod	_	_
11	steps	step	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	characterized	characterize	VBN	VBN	_	7	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	u.v.	u.v.	NN	NN	_	16	compound	_	_
16	cross-linking	cross-linking	NN	NN	_	13	nmod	_	_
17	as	as	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	47	47	CD	CD	_	21	nummod	_	_
20	kDa	kda	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	0	root	_	_
3	known	know	VBN	VBN	_	2	acl	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	bind	bind	VB	VB	_	3	xcomp	_	_
6	to	to	TO	TO	_	11	case	_	_
7	endogenous	endogenous	JJ	JJ	_	11	amod	_	_
8	Ig	ig	NN	NN	_	11	compound	_	_
9	heavy	heavy	JJ	JJ	_	11	amod	_	_
10	chain	chain	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	5	nmod	_	_
12	only	only	RB	RB	_	14	advmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
15	is	be	VBZ	VBZ	_	20	cop	_	_
16	a	a	DT	DT	_	20	det	_	_
17	ubiquitously	ubiquitously	RB	RB	_	20	advmod	_	_
18	active	active	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	2	dep	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	enhancer	enhancer	NN	NN	_	19	nsubj	_	_
4	located	located	JJ	JJ	_	3	amod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	first	first	JJ	JJ	_	8	amod	_	_
8	intron	intron	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	immunoglobulin	immunoglobulin	NN	NN	_	15	compound	_	_
12	heavy	heavy	JJ	JJ	_	15	amod	_	_
13	chain	chain	NN	NN	_	15	compound	_	_
14	constant	constant	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	8	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	major	major	JJ	JJ	_	19	amod	_	_
19	determinant	determinant	NN	NN	_	0	root	_	_
20	of	of	IN	IN	_	22	case	_	_
21	B-cell-specific	b-cell-specific	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	immunoglobulin	immunoglobulin	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	Like	like	IN	IN	_	3	case	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	enhancers	enhancer	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Ig	ig	NN	NN	_	9	compound	_	_
7	heavy	heavy	JJ	JJ	_	9	amod	_	_
8	chain	chain	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	10	nsubj	_	_
10	contains	contain	VBZ	VBZ	_	0	root	_	_
11	several	several	JJ	JJ	_	14	amod	_	_
12	short	short	JJ	JJ	_	14	amod	_	_
13	sequence	sequence	NN	NN	_	14	compound	_	_
14	motifs	motif	NNS	NNS	_	10	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	bind	bind	VBP	VBP	_	14	acl:relcl	_	_
17	specific	specific	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	16	dobj	_	_
20	.	.	.	.	_	10	punct	_	_

1	Each	each	DT	DT	_	3	det	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	site	site	NN	NN	_	4	nsubj	_	_
4	contributes	contribute	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	overall	overall	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	enhancer	enhancer	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	however	however	RB	RB	_	17	advmod	_	_
14	no	no	DT	DT	_	16	neg	_	_
15	single	single	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	17	nsubj	_	_
17	seems	seem	VBZ	VBZ	_	4	parataxis	_	_
18	absolutely	absolutely	RB	RB	_	17	advmod	_	_
19	required	require	VBN	VBN	_	17	xcomp	_	_
20	for	for	IN	IN	_	21	case	_	_
21	activity	activity	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	For	for	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	better	better	JJR	JJR	_	4	amod	_	_
4	understanding	understanding	NN	NN	_	13	dep	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	Ig	ig	NN	NN	_	11	compound	_	_
8	heavy	heavy	JJ	JJ	_	11	amod	_	_
9	chain	chain	NN	NN	_	11	compound	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	components	component	NNS	NNS	_	4	nmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	we	we	PRP	PRP	_	0	root	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	cloned	clone	VBN	VBN	_	13	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	analyzed	analyze	VBN	VBN	_	15	conj	_	_
18	individual	individual	JJ	JJ	_	20	amod	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	17	dobj	_	_
21	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	factor	factor	NN	NN	_	20	nsubj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	E3	e3	NN	NN	_	12	compound	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	motif	motif	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	CATGTGGC	catgtggc	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	5	punct	_	_
16	is	be	VBZ	VBZ	_	20	cop	_	_
17	a	a	DT	DT	_	20	det	_	_
18	ubiquitous	ubiquitous	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	2	ccomp	_	_
21	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	present	present	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	form	form	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	non-B	non-b	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	where	where	WRB	WRB	_	19	advmod	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	mediate	mediate	VB	VB	_	11	acl:relcl	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	24	advmod	_	_
24	and	and	CC	CC	_	19	advmod	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	24	advmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	despite	despite	IN	IN	_	5	case	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	ability	ability	NN	NN	_	19	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	5	acl	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	transfected	transfect	VBN	VBN	_	13	amod	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	factor	factor	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	apparently	apparently	RB	RB	_	19	advmod	_	_
19	unable	unable	JJ	JJ	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	bind	bind	VB	VB	_	19	xcomp	_	_
22	to	to	TO	TO	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	endogenous	endogenous	JJ	JJ	_	28	amod	_	_
25	Ig	ig	NN	NN	_	28	compound	_	_
26	heavy	heavy	JJ	JJ	_	28	amod	_	_
27	chain	chain	NN	NN	_	28	compound	_	_
28	enhancer	enhancer	NN	NN	_	21	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	non-lymphoid	non-lymphoid	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	:	:	:	:	_	19	punct	_	_
33	In	in	IN	IN	_	35	case	_	_
34	previous	previous	JJ	JJ	_	35	amod	_	_
35	experiments	experiment	NNS	NNS	_	52	nmod	_	_
36	by	by	IN	IN	_	37	case	_	_
37	others	other	NNS	NNS	_	35	nmod	_	_
38	,	,	,	,	_	52	punct	_	_
39	the	the	DT	DT	_	43	det	_	_
40	characteristic	characteristic	JJ	JJ	_	43	amod	_	_
41	in	in	FW	FW	_	40	dep	_	_
42	vivo	vivo	FW	FW	_	41	dep	_	_
43	footprint	footprint	NN	NN	_	52	nsubjpass	_	_
44	of	of	IN	IN	_	46	case	_	_
45	this	this	DT	DT	_	46	det	_	_
46	factor	factor	NN	NN	_	43	nmod	_	_
47	,	,	,	,	_	46	punct	_	_
48	designated	designate	VBN	VBN	_	46	acl	_	_
49	NF-muE3	nf-mue3	NN	NN	_	48	xcomp	_	_
50	,	,	,	,	_	43	punct	_	_
51	was	be	VBD	VBD	_	52	auxpass	_	_
52	detected	detect	VBN	VBN	_	19	parataxis	_	_
53	in	in	IN	IN	_	55	case	_	_
54	B	b	NN	NN	_	55	compound	_	_
55	cells	cell	NNS	NNS	_	52	nmod	_	_
56	but	but	CC	CC	_	55	cc	_	_
57	not	not	RB	RB	_	60	neg	_	_
58	in	in	IN	IN	_	60	case	_	_
59	non-B	non-b	JJ	JJ	_	60	amod	_	_
60	cells	cell	NNS	NNS	_	55	conj	_	_
61	.	.	.	.	_	19	punct	_	_

1	From	from	IN	IN	_	2	case	_	_
2	this	this	DT	DT	_	8	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	other	other	JJ	JJ	_	2	conj	_	_
5	findings	finding	NNS	NNS	_	2	dep	_	_
6	the	the	DT	DT	_	7	det	_	_
7	picture	picture	NN	NN	_	8	nsubj	_	_
8	emerges	emerge	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	there	there	EX	EX	_	11	expl	_	_
11	are	be	VBP	VBP	_	8	dep	_	_
12	at	at	IN	IN	_	13	case	_	_
13	least	least	JJS	JJS	_	14	nmod:npmod	_	_
14	three	three	CD	CD	_	15	nummod	_	_
15	categories	category	NNS	NNS	_	11	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	factors	factor	NNS	NNS	_	15	nmod	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	mediate	mediate	VBP	VBP	_	15	acl:relcl	_	_
20	cell-type-specific	cell-type-specific	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
25	:	:	:	:	_	8	punct	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	a	a	LS	LS	_	30	dep	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	cell-specific	cell-specific	JJ	JJ	_	30	amod	_	_
30	factors	factor	NNS	NNS	_	8	dep	_	_
31	such	such	JJ	JJ	_	33	case	_	_
32	as	as	IN	IN	_	31	mwe	_	_
33	Oct-2A	oct-2a	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Oct-2B	oct-2b	NN	NN	_	33	conj	_	_
36	that	that	WDT	WDT	_	39	nsubjpass	_	_
37	are	be	VBP	VBP	_	39	auxpass	_	_
38	not	not	RB	RB	_	39	neg	_	_
39	expressed	express	VBN	VBN	_	30	acl:relcl	_	_
40	in	in	IN	IN	_	44	case	_	_
41	most	most	JJS	JJS	_	44	amod	_	_
42	other	other	JJ	JJ	_	44	amod	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	types	type	NNS	NNS	_	39	nmod	_	_
45	:	:	:	:	_	30	punct	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	b	b	LS	LS	_	50	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	ubiquitous	ubiquitous	JJ	JJ	_	50	amod	_	_
50	factors	factor	NNS	NNS	_	30	dep	_	_
51	such	such	JJ	JJ	_	54	case	_	_
52	as	as	IN	IN	_	51	mwe	_	_
53	NF-kappa	nf-kappa	NN	NN	_	54	compound	_	_
54	B	b	NN	NN	_	50	nmod	_	_
55	that	that	WDT	WDT	_	58	nsubj	_	_
56	are	be	VBP	VBP	_	58	cop	_	_
57	constitutively	constitutively	RB	RB	_	58	advmod	_	_
58	active	active	JJ	JJ	_	50	acl:relcl	_	_
59	in	in	IN	IN	_	61	case	_	_
60	B	b	NN	NN	_	61	compound	_	_
61	cells	cell	NNS	NNS	_	58	nmod	_	_
62	but	but	CC	CC	_	58	cc	_	_
63	are	be	VBP	VBP	_	64	auxpass	_	_
64	sequestered	sequester	VBN	VBN	_	58	conj	_	_
65	in	in	IN	IN	_	68	case	_	_
66	an	a	DT	DT	_	68	det	_	_
67	inactive	inactive	JJ	JJ	_	68	amod	_	_
68	form	form	NN	NN	_	64	nmod	_	_
69	in	in	IN	IN	_	71	case	_	_
70	other	other	JJ	JJ	_	71	amod	_	_
71	cells	cell	NNS	NNS	_	68	nmod	_	_
72	;	;	:	:	_	50	punct	_	_
73	(	(	-LRB-	-LRB-	_	74	punct	_	_
74	c	c	LS	LS	_	78	dep	_	_
75	)	)	-RRB-	-RRB-	_	74	punct	_	_
76	ubiquitously	ubiquitously	RB	RB	_	78	advmod	_	_
77	active	active	JJ	JJ	_	78	amod	_	_
78	factors	factor	NNS	NNS	_	30	dep	_	_
79	,	,	,	,	_	78	punct	_	_
80	exemplified	exemplify	VBN	VBN	_	78	acl	_	_
81	by	by	IN	IN	_	83	case	_	_
82	the	the	DT	DT	_	83	det	_	_
83	one	one	NN	NN	_	80	nmod	_	_
84	binding	bind	VBG	VBG	_	83	amod	_	_
85	to	to	TO	TO	_	89	case	_	_
86	the	the	DT	DT	_	89	det	_	_
87	E3	e3	NN	NN	_	89	compound	_	_
88	sequence	sequence	NN	NN	_	89	compound	_	_
89	motif	motif	NN	NN	_	83	nmod	_	_
90	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	active	active	JJ	JJ	_	8	amod	_	_
8	form	form	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	types	type	NNS	NNS	_	11	nmod	_	_
15	but	but	CC	CC	_	4	cc	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	apparently	apparently	RB	RB	_	18	advmod	_	_
18	unable	unable	JJ	JJ	_	4	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	bind	bind	VB	VB	_	18	xcomp	_	_
21	to	to	TO	TO	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	endogenous	endogenous	JJ	JJ	_	27	amod	_	_
24	Ig	ig	NN	NN	_	27	compound	_	_
25	heavy	heavy	JJ	JJ	_	27	amod	_	_
26	chain	chain	NN	NN	_	27	compound	_	_
27	enhancer	enhancer	NN	NN	_	20	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	non-B	non-b	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	20	nmod	_	_
31	,	,	,	,	_	20	punct	_	_
32	perhaps	perhaps	RB	RB	_	38	advmod	_	_
33	due	due	JJ	JJ	_	38	case	_	_
34	to	to	TO	TO	_	33	mwe	_	_
35	a	a	DT	DT	_	38	det	_	_
36	non-permissive	non-permissive	JJ	JJ	_	38	amod	_	_
37	chromatin	chromatin	NN	NN	_	38	compound	_	_
38	structure	structure	NN	NN	_	20	nmod	_	_
39	of	of	IN	IN	_	44	case	_	_
40	the	the	DT	DT	_	44	det	_	_
41	Ig	ig	NN	NN	_	44	compound	_	_
42	heavy	heavy	JJ	JJ	_	44	amod	_	_
43	chain	chain	NN	NN	_	44	compound	_	_
44	locus	locus	NN	NN	_	38	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	post-transcriptional	post-transcriptional	JJ	JJ	_	1	conj	_	_
4	regulation	regulation	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	c-jun	c-jun	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	during	during	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
14	leukemic	leukemic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	AP-1	ap-1	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	polypeptide	polypeptide	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	7	case	_	_
7	c-jun	c-jun	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	recognizes	recognize	VBZ	VBZ	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	binds	bind	VBZ	VBZ	_	9	conj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	sequences	sequence	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	stimulates	stimulate	VBZ	VBZ	_	9	conj	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	responsive	responsive	JJ	JJ	_	20	amod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	certain	certain	JJ	JJ	_	25	amod	_	_
24	growth	growth	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	phorbol	phorbol	NN	NN	_	28	compound	_	_
28	esters	ester	NNS	NNS	_	25	conj	_	_
29	such	such	JJ	JJ	_	31	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TPA	tpa	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	TPA	tpa	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	c-jun	c-jun	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HL-60	hl-60	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	during	during	IN	IN	_	19	case	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Low	low	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	detectable	detectable	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	untreated	untreated	JJ	JJ	_	12	amod	_	_
10	HL-60	hl-60	NN	NN	_	12	compound	_	_
11	leukemic	leukemic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	increased	increase	VBD	VBD	_	7	dep	_	_
15	significantly	significantly	RB	RB	_	14	advmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	6	6	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	reached	reach	VBD	VBD	_	14	conj	_	_
22	near	near	IN	IN	_	24	case	_	_
23	maximal	maximal	JJ	JJ	_	24	amod	_	_
24	levels	level	NNS	NNS	_	21	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	24	24	CD	CD	_	27	nummod	_	_
27	h	h	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	exposure	exposure	NN	NN	_	27	nmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	32	32	CD	CD	_	32	compound	_	_
32	nM	nm	NN	NN	_	33	amod	_	_
33	TPA	tpa	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	kinetics	kinetics	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	TPA	tpa	NN	NN	_	5	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	U-937	u-937	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	THP-1	thp-1	NN	NN	_	17	compound	_	_
15	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
16	leukemia	leukemia	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	conj	_	_
18	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	findings	finding	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	bryostatin	bryostatin	NN	NN	_	4	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	nM	nm	NN	NN	_	6	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	6	punct	_	_
13	another	another	DT	DT	_	14	det	_	_
14	activator	activator	NN	NN	_	6	appos	_	_
15	of	of	IN	IN	_	18	case	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	inducer	inducer	NN	NN	_	14	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	4	compound	_	_
4	D3	d3	NN	NN	_	21	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	0.5	0.5	CD	CD	_	7	nummod	_	_
7	microM	microm	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	4	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	structurally	structurally	RB	RB	_	12	advmod	_	_
12	distinct	distinct	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	4	appos	_	_
14	which	which	WDT	WDT	_	16	nsubj	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	induces	induce	VBZ	VBZ	_	13	acl:relcl	_	_
17	HL-60	hl-60	NN	NN	_	19	compound	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	4	punct	_	_
21	increased	increase	VBD	VBD	_	0	root	_	_
22	c-jun	c-jun	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	21	punct	_	_

1	TPA	tpa	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HL-60	hl-60	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	cycloheximide	cycloheximide	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	superinduction	superinduction	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	c-jun	c-jun	NN	NN	_	17	compound	_	_
17	transcripts	transcript	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Run-on	run-on	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	detectable	detectable	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	c-jun	c-jun	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	untreated	untreated	JJ	JJ	_	13	amod	_	_
12	HL-60	hl-60	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	that	that	IN	IN	_	17	amod	_	_
17	exposure	exposure	NN	NN	_	20	nsubj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	TPA	tpa	NN	NN	_	17	nmod	_	_
20	increases	increase	VBZ	VBZ	_	3	conj	_	_
21	this	this	DT	DT	_	22	det	_	_
22	rate	rate	NN	NN	_	20	iobj	_	_
23	3.3-fold	3.3-fold	RB	RB	_	20	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Treatment	treatment	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HL-60	hl-60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	TPA	tpa	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cycloheximide	cycloheximide	NN	NN	_	7	conj	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	effect	effect	NN	NN	_	10	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	rates	rate	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	c-jun	c-jun	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	half-life	half-life	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	RNA	rna	NN	NN	_	2	nmod	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	determined	determine	VBN	VBN	_	19	dep	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	treating	treat	VBG	VBG	_	7	advcl	_	_
10	HL-60	hl-60	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	9	dobj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	TPA	tpa	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	actinomycin	actinomycin	NN	NN	_	16	compound	_	_
16	D	d	NN	NN	_	13	conj	_	_
17	was	be	VBD	VBD	_	19	cop	_	_
18	30	30	CD	CD	_	19	nummod	_	_
19	min	min	NN	NN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	half-life	half-life	NN	NN	_	20	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	c-jun	c-jun	NN	NN	_	8	compound	_	_
8	RNA	rna	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	TPA-treated	tpa-treated	JJ	JJ	_	12	amod	_	_
11	HL-60	hl-60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	exposed	expose	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	cycloheximide	cycloheximide	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	actinomycin	actinomycin	NN	NN	_	18	compound	_	_
18	D	d	NN	NN	_	15	conj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	greater	greater	JJR	JJR	_	0	root	_	_
21	than	than	IN	IN	_	23	case	_	_
22	2	2	CD	CD	_	23	nummod	_	_
23	h	h	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	increase	increase	NN	NN	_	16	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	c-jun	c-jun	NN	NN	_	9	compound	_	_
9	RNA	rna	NN	NN	_	6	nmod	_	_
10	observed	observe	VBN	VBN	_	6	acl	_	_
11	during	during	IN	IN	_	14	case	_	_
12	TPA-induced	tpa-induced	JJ	JJ	_	14	amod	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	transcriptional	transcriptional	JJ	JJ	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	post-transcriptional	post-transcriptional	JJ	JJ	_	19	conj	_	_
22	mechanisms	mechanism	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	3	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	0	root	_	_
3	as	as	IN	IN	_	6	case	_	_
4	inducible	inducible	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	12	amod	_	_
10	colony-stimulating	colony-stimulating	JJ	JJ	_	12	amod	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	gene	gene	NN	NN	_	2	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	10	amod	_	_
9	colony-stimulating	colony-stimulating	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	6	dobj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	GM-CSF	gm-csf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	upon	upon	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	phytohemagglutinin	phytohemagglutinin	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	active	active	JJ	JJ	_	25	amod	_	_
25	phorbolester	phorbolester	NN	NN	_	22	conj	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	upon	upon	IN	IN	_	28	case	_	_
28	expression	expression	NN	NN	_	17	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	tax1	tax1	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	a	a	DT	DT	_	34	det	_	_
33	transactivating	transactivate	VBG	VBG	_	34	amod	_	_
34	protein	protein	NN	NN	_	30	appos	_	_
35	of	of	IN	IN	_	41	case	_	_
36	the	the	DT	DT	_	41	det	_	_
37	human	human	JJ	JJ	_	41	amod	_	_
38	T-cell	t-cell	NN	NN	_	41	compound	_	_
39	leukemia	leukemia	NN	NN	_	41	compound	_	_
40	virus	virus	NN	NN	_	41	compound	_	_
41	type	type	NN	NN	_	34	nmod	_	_
42	I	i	CD	CD	_	41	nummod	_	_
43	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	same	same	JJ	JJ	_	3	amod	_	_
3	agents	agent	NNS	NNS	_	4	nsubj	_	_
4	induce	induce	VBP	VBP	_	0	root	_	_
5	transcription	transcription	NN	NN	_	4	dobj	_	_
6	from	from	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	dep	_	_
8	interleukin-2	interleukin-2	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	alpha-chain	alpha-chain	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	interleukin-2	interleukin-2	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	10	dep	_	_
14	,	,	,	,	_	4	punct	_	_
15	depending	depend	VBG	VBG	_	18	case	_	_
16	on	on	IN	IN	_	18	case	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	4	advcl	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	bind	bind	VBP	VBP	_	18	acl:relcl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	inducible	inducible	JJ	JJ	_	24	amod	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	20	dobj	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	24	dep	_	_
27	(	(	-LRB-	-LRB-	_	32	punct	_	_
28	or	or	CC	CC	_	32	cc	_	_
29	an	a	DT	DT	_	32	det	_	_
30	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
31	B-like	b-like	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	24	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	tested	test	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	GM-CSF	gm-csf	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	regulated	regulate	VBN	VBN	_	5	ccomp	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	cognate	cognate	JJ	JJ	_	16	amod	_	_
16	motif	motif	NN	NN	_	12	nmod	_	_
17	for	for	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	recent	recent	JJ	JJ	_	4	amod	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	32	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	Miyatake	Miyatake	NNP	NNP	_	4	nmod	_	_
7	et	et	FW	FW	_	6	compound	_	_
8	al.	al.	FW	FW	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	S.	S.	NNP	NNP	_	11	compound	_	_
11	Miyatake	Miyatake	NNP	NNP	_	6	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	M.	M.	NNP	NNP	_	14	compound	_	_
14	Seiki	Seiki	NNP	NNP	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	M.	M.	NNP	NNP	_	17	compound	_	_
17	Yoshida	Yoshida	NNP	NNP	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	K.	K.	NNP	NNP	_	21	compound	_	_
21	Arai	Arai	NNP	NNP	_	11	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	Mol.	Mol.	NNP	NNP	_	25	compound	_	_
24	Cell.	Cell.	NNP	NNP	_	25	compound	_	_
25	Biol.	Biol.	NNP	NNP	_	11	appos	_	_
26	8	8	CD	CD	_	25	nummod	_	_
27	:	:	:	:	_	11	punct	_	_
28	5581-5587	5581-5587	CD	CD	_	11	dep	_	_
29	,	,	,	,	_	11	punct	_	_
30	1988	1988	CD	CD	_	11	amod	_	_
31	)	)	-RRB-	-RRB-	_	11	punct	_	_
32	described	describe	VBD	VBD	_	0	root	_	_
33	a	a	DT	DT	_	36	det	_	_
34	short	short	JJ	JJ	_	36	amod	_	_
35	promoter	promoter	NN	NN	_	36	compound	_	_
36	region	region	NN	NN	_	32	dobj	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	GM-CSF	gm-csf	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	36	nmod	_	_
41	that	that	WDT	WDT	_	42	nsubj	_	_
42	conferred	confer	VBD	VBD	_	40	acl:relcl	_	_
43	strong	strong	JJ	JJ	_	44	amod	_	_
44	inducibility	inducibility	NN	NN	_	42	dobj	_	_
45	by	by	IN	IN	_	47	case	_	_
46	T-cell-activating	t-cell-activating	JJ	JJ	_	47	amod	_	_
47	signals	signal	NNS	NNS	_	44	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	tax1	tax1	NN	NN	_	47	conj	_	_
50	,	,	,	,	_	32	punct	_	_
51	but	but	CC	CC	_	32	cc	_	_
52	no	no	DT	DT	_	55	neg	_	_
53	NF-kappa	nf-kappa	NN	NN	_	55	compound	_	_
54	B-binding	b-binding	NN	NN	_	55	compound	_	_
55	motifs	motif	NNS	NNS	_	57	nsubjpass	_	_
56	were	be	VBD	VBD	_	57	auxpass	_	_
57	identified	identify	VBN	VBN	_	32	conj	_	_
58	.	.	.	.	_	32	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	1	parataxis	_	_
9	binding	binding	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	purified	purify	VBN	VBN	_	14	amod	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	14	conj	_	_
20	activated	activate	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	Jurkat	jurkat	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	an	a	DT	DT	_	27	det	_	_
27	oligonucleotide	oligonucleotide	NN	NN	_	9	nmod	_	_
28	comprising	comprise	VBG	VBG	_	27	acl	_	_
29	the	the	DT	DT	_	32	det	_	_
30	GM-CSF	gm-csf	NN	NN	_	32	compound	_	_
31	promoter	promoter	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	28	dobj	_	_
33	responsible	responsible	JJ	JJ	_	32	amod	_	_
34	for	for	IN	IN	_	35	mark	_	_
35	mediating	mediate	VBG	VBG	_	33	advcl	_	_
36	responsiveness	responsiveness	NN	NN	_	35	dobj	_	_
37	to	to	TO	TO	_	39	case	_	_
38	T-cell-activating	t-cell-activating	JJ	JJ	_	39	amod	_	_
39	signals	signal	NNS	NNS	_	36	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	tax1	tax1	NN	NN	_	39	conj	_	_
42	.	.	.	.	_	1	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	shown	show	VBN	VBN	_	16	advcl	_	_
3	by	by	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	methylation	methylation	NN	NN	_	7	compound	_	_
6	interference	interference	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	oligonucleotide	oligonucleotide	NN	NN	_	11	compound	_	_
10	competition	competition	NN	NN	_	11	compound	_	_
11	experiments	experiment	NNS	NNS	_	7	conj	_	_
12	,	,	,	,	_	16	punct	_	_
13	purified	purify	VBN	VBN	_	15	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	nsubj	_	_
16	binds	bind	VBZ	VBZ	_	0	root	_	_
17	at	at	IN	IN	_	18	case	_	_
18	positions	position	NNS	NNS	_	16	nmod	_	_
19	-82	-82	CD	CD	_	18	nummod	_	_
20	to	to	TO	TO	_	18	dep	_	_
21	-91	-91	CD	CD	_	18	nummod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	GGGAACTACC	gggaactacc	NN	NN	_	18	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	GM-CSF	gm-csf	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	29	compound	_	_
29	sequence	sequence	NN	NN	_	18	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	an	a	DT	DT	_	32	det	_	_
32	affinity	affinity	NN	NN	_	16	nmod	_	_
33	similar	similar	JJ	JJ	_	32	amod	_	_
34	to	to	TO	TO	_	35	case	_	_
35	that	that	DT	DT	_	33	nmod	_	_
36	with	with	IN	IN	_	37	case	_	_
37	which	which	WDT	WDT	_	39	nmod	_	_
38	it	it	PRP	PRP	_	39	nsubj	_	_
39	binds	bind	VBZ	VBZ	_	35	acl:relcl	_	_
40	to	to	TO	TO	_	46	case	_	_
41	the	the	DT	DT	_	46	det	_	_
42	biologically	biologically	RB	RB	_	46	advmod	_	_
43	functional	functional	JJ	JJ	_	46	amod	_	_
44	kappa	kappa	NN	NN	_	46	compound	_	_
45	B	b	NN	NN	_	46	compound	_	_
46	motif	motif	NN	NN	_	39	nmod	_	_
47	in	in	IN	IN	_	51	case	_	_
48	the	the	DT	DT	_	51	det	_	_
49	beta	beta	NN	NN	_	51	compound	_	_
50	interferon	interferon	NN	NN	_	51	compound	_	_
51	promoter	promoter	NN	NN	_	46	nmod	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	GGGAAATTCC	gggaaattcc	NN	NN	_	46	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	.	.	.	.	_	16	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B-like	b-like	JJ	JJ	_	4	amod	_	_
4	motifs	motif	NNS	NNS	_	16	nsubjpass	_	_
5	at	at	IN	IN	_	6	case	_	_
6	positions	position	NNS	NNS	_	4	nmod	_	_
7	-98	-98	CD	CD	_	6	nummod	_	_
8	to	to	TO	TO	_	6	dep	_	_
9	-108	-108	CD	CD	_	6	nummod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	6	nmod	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	recognized	recognize	VBN	VBN	_	0	root	_	_
17	but	but	CC	CC	_	16	cc	_	_
18	with	with	IN	IN	_	21	case	_	_
19	much	much	JJ	JJ	_	21	amod	_	_
20	lower	lower	JJR	JJR	_	19	dep	_	_
21	affinities	affinity	NNS	NNS	_	16	conj	_	_
22	.	.	.	.	_	16	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	strong	strong	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	17	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	GM-CSF	gm-csf	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	following	follow	VBG	VBG	_	15	case	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	8	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	controlled	control	VBN	VBN	_	5	ccomp	_	_
18	by	by	IN	IN	_	19	case	_	_
19	binding	binding	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	19	nmod	_	_
26	to	to	TO	TO	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	high-affinity	high-affinity	JJ	JJ	_	30	amod	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	19	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	GM-CSF	gm-csf	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	ubiquitous	ubiquitous	JJ	JJ	_	4	amod	_	_
3	octamer-binding	octamer-binding	JJ	JJ	_	4	amod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	s	s	NNS	NNS	_	9	nsubj	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	sufficient	sufficient	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	transcription	transcription	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	immunoglobulin	immunoglobulin	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	immunoglobulin	immunoglobulin	NN	NN	_	3	compound	_	_
3	genes	gene	NNS	NNS	_	4	nsubj	_	_
4	contain	contain	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	conserved	conserve	VBN	VBN	_	9	amod	_	_
7	octanucleotide	octanucleotide	NN	NN	_	9	compound	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	4	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	ATGCAAAT	atgcaaat	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	which	which	WDT	WDT	_	16	nsubjpass	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	shown	show	VBN	VBN	_	9	acl:relcl	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	16	xcomp	_	_
20	for	for	IN	IN	_	24	case	_	_
21	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
22	normal	normal	JJ	JJ	_	24	amod	_	_
23	B-cell-specific	b-cell-specific	JJ	JJ	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Proteins	protein	NNS	NNS	_	8	nsubjpass	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	bind	bind	VBP	VBP	_	1	acl:relcl	_	_
4	this	this	DT	DT	_	5	det	_	_
5	octamer	octamer	NN	NN	_	3	dobj	_	_
6	have	have	VBP	VBP	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	purified	purify	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	cDNAs	cdna	NNS	NNS	_	17	nsubjpass	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	octamer-binding	octamer-binding	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	12	dobj	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	cloned	clone	VBN	VBN	_	8	conj	_	_
18	.	.	.	.	_	8	punct	_	_

1	Some	some	DT	DT	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	referred	refer	VBN	VBN	_	1	dep	_	_
7	to	to	TO	TO	_	6	nmod	_	_
8	as	as	IN	IN	_	9	case	_	_
9	OTF-2	otf-2	NN	NN	_	6	nmod	_	_
10	)	)	-RRB-	-RRB-	_	6	punct	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
13	specific	specific	JJ	JJ	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	whereas	whereas	IN	IN	_	32	mark	_	_
16	at	at	IN	IN	_	17	case	_	_
17	least	least	JJS	JJS	_	18	nmod:npmod	_	_
18	one	one	CD	CD	_	19	nummod	_	_
19	other	other	JJ	JJ	_	32	nsubjpass	_	_
20	,	,	,	,	_	19	punct	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	possibly	possibly	RB	RB	_	23	advmod	_	_
23	more	more	JJR	JJR	_	19	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	referred	refer	VBN	VBN	_	19	dep	_	_
26	to	to	TO	TO	_	25	nmod	_	_
27	as	as	IN	IN	_	28	case	_	_
28	OTF-1	otf-1	NN	NN	_	25	nmod	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	,	,	,	,	_	19	punct	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	found	find	VBN	VBN	_	13	advcl	_	_
33	ubiquitously	ubiquitously	RB	RB	_	32	advmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	all	all	DT	DT	_	37	det	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	types	type	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	exact	exact	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	these	these	DT	DT	_	7	det	_	_
6	different	different	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	directing	direct	VBG	VBG	_	3	acl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	tissue-specific	tissue-specific	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	immunoglobulin	immunoglobulin	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	unclear	unclear	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	two	two	CD	CD	_	7	nummod	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	pre-B-cell	pre-b-cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	contain	contain	VBP	VBP	_	7	acl:relcl	_	_
10	extremely	extremely	RB	RB	_	11	advmod	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	OTF-2	otf-2	NN	NN	_	12	nmod	_	_
15	yet	yet	CC	CC	_	9	cc	_	_
16	still	still	RB	RB	_	9	advmod	_	_
17	express	express	VBP	VBP	_	9	dep	_	_
18	high	high	JJ	JJ	_	19	amod	_	_
19	levels	level	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	steady-state	steady-state	JJ	JJ	_	24	amod	_	_
22	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
23	heavy-chain	heavy-chain	JJ	JJ	_	24	amod	_	_
24	mRNA	mrna	NN	NN	_	19	nmod	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	17	advmod	_	_
27	and	and	CC	CC	_	17	cc	_	_
28	efficiently	efficiently	RB	RB	_	29	advmod	_	_
29	transcribe	transcribe	VBP	VBP	_	17	conj	_	_
30	an	a	DT	DT	_	32	det	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	29	dobj	_	_
33	in	in	FW	FW	_	34	compound	_	_
34	vitro	vitro	FW	FW	_	29	advmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Addition	addition	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	highly	highly	RB	RB	_	5	advmod	_	_
5	enriched	enriched	JJ	JJ	_	6	amod	_	_
6	preparation	preparation	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	OTF-1	otf-1	NN	NN	_	6	nmod	_	_
9	made	make	VBN	VBN	_	6	acl	_	_
10	from	from	IN	IN	_	11	case	_	_
11	one	one	CD	CD	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	pre-B	pre-b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	or	or	CC	CC	_	11	cc	_	_
17	from	from	IN	IN	_	19	case	_	_
18	HeLa	hela	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	conj	_	_
20	specifically	specifically	RB	RB	_	21	advmod	_	_
21	stimulated	stimulate	VBD	VBD	_	0	root	_	_
22	in	in	FW	FW	_	24	amod	_	_
23	vitro	vitro	FW	FW	_	22	dep	_	_
24	transcription	transcription	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	immunoglobulin	immunoglobulin	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	OFT-1	oft-1	NN	NN	_	4	nsubj	_	_
4	appeared	appear	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	have	have	VB	VB	_	4	xcomp	_	_
7	approximately	approximately	RB	RB	_	11	advmod	_	_
8	the	the	DT	DT	_	11	det	_	_
9	same	same	JJ	JJ	_	11	amod	_	_
10	transactivation	transactivation	NN	NN	_	11	compound	_	_
11	ability	ability	NN	NN	_	6	dobj	_	_
12	as	as	IN	IN	_	13	case	_	_
13	OTF-2	otf-2	NN	NN	_	11	nmod	_	_
14	when	when	WRB	WRB	_	15	advmod	_	_
15	normalized	normalize	VBN	VBN	_	4	advcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	OTF-1	otf-1	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	without	without	IN	IN	_	8	case	_	_
8	OTF-2	otf-2	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	13	case	_	_
13	transcription	transcription	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	immunoglobulin	immunoglobulin	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	OTF-2	otf-2	NN	NN	_	23	nsubj	_	_
20	alone	alone	RB	RB	_	19	advmod	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	responsible	responsible	JJ	JJ	_	11	conj	_	_
24	for	for	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	B-cell-specific	b-cell-specific	JJ	JJ	_	27	amod	_	_
27	regulation	regulation	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	immunoglobulin	immunoglobulin	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Perceived	perceive	VBN	VBN	_	3	amod	_	_
2	social	social	JJ	JJ	_	3	amod	_	_
3	support	support	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tumor	tumor	NN	NN	_	8	compound	_	_
6	estrogen/progesterone	estrogen/progesterone	JJ	JJ	_	7	amod	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	status	status	NN	NN	_	3	conj	_	_
9	as	as	IN	IN	_	10	case	_	_
10	predictors	predictor	NNS	NNS	_	3	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	natural	natural	JJ	JJ	_	14	amod	_	_
13	killer	killer	NN	NN	_	14	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	breast	breast	NN	NN	_	19	compound	_	_
18	cancer	cancer	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	3	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	concerned	concern	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	prediction	prediction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	15	case	_	_
9	natural	natural	JJ	JJ	_	15	amod	_	_
10	killer	killer	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	NK	nk	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	7	nmod	_	_
16	in	in	IN	IN	_	24	case	_	_
17	61	61	CD	CD	_	24	nummod	_	_
18	Stage	stage	NN	NN	_	24	compound	_	_
19	I	i	CD	CD	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	II	ii	CD	CD	_	18	conj	_	_
22	breast	breast	NN	NN	_	23	compound	_	_
23	cancer	cancer	NN	NN	_	18	dep	_	_
24	patients	patient	NNS	NNS	_	15	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	between	between	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	ages	age	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	25	25	CD	CD	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	70	70	CD	CD	_	30	conj	_	_
33	,	,	,	,	_	24	punct	_	_
34	who	who	WP	WP	_	36	nsubjpass	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	accrued	accrue	VBN	VBN	_	24	acl:relcl	_	_
37	to	to	TO	TO	_	39	case	_	_
38	this	this	DT	DT	_	39	det	_	_
39	project	project	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	All	all	DT	DT	_	3	dep	_	_
2	baseline	baseline	NN	NN	_	3	compound	_	_
3	interview	interview	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	testing	testing	NN	NN	_	6	compound	_	_
6	data	datum	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	obtained	obtain	VBN	VBN	_	0	root	_	_
9	either	either	CC	CC	_	8	dep	_	_
10	just	just	RB	RB	_	14	advmod	_	_
11	before	before	IN	IN	_	14	mark	_	_
12	patients	patient	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	discharged	discharge	VBN	VBN	_	9	dep	_	_
15	from	from	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	hospital	hospital	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	or	or	CC	CC	_	8	cc	_	_
20	at	at	IN	IN	_	24	case	_	_
21	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
22	first	first	JJ	JJ	_	24	amod	_	_
23	outpatient	outpatient	JJ	JJ	_	24	amod	_	_
24	visit	visit	NN	NN	_	8	conj	_	_
25	,	,	,	,	_	24	punct	_	_
26	within	within	IN	IN	_	28	case	_	_
27	two	two	CD	CD	_	28	nummod	_	_
28	weeks	week	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	discharge	discharge	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	interest	interest	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	project	project	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	the	the	DT	DT	_	10	det	_	_
9	predictive	predictive	JJ	JJ	_	10	amod	_	_
10	value	value	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	perceived	perceive	VBN	VBN	_	14	amod	_	_
13	social	social	JJ	JJ	_	14	amod	_	_
14	support	support	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	as	as	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	potential	potential	JJ	JJ	_	21	amod	_	_
19	``	``	``	``	_	21	punct	_	_
20	stress	stress	NN	NN	_	21	compound	_	_
21	buffer	buffer	NN	NN	_	10	nmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	related	relate	VBN	VBN	_	10	acl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	NK	nk	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	main	main	JJ	JJ	_	4	amod	_	_
4	model	model	NN	NN	_	9	nmod	_	_
5	reported	report	VBN	VBN	_	4	acl	_	_
6	here	here	RB	RB	_	5	advmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	found	find	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	20	mark	_	_
11	a	a	DT	DT	_	13	det	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	amount	amount	NN	NN	_	20	nsubjpass	_	_
14	of	of	IN	IN	_	17	case	_	_
15	NK	nk	NN	NN	_	17	compound	_	_
16	activity	activity	NN	NN	_	17	compound	_	_
17	variance	variance	NN	NN	_	13	nmod	_	_
18	could	could	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	explained	explain	VBN	VBN	_	9	ccomp	_	_
21	by	by	IN	IN	_	23	case	_	_
22	five	five	CD	CD	_	23	nummod	_	_
23	variables	variable	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Higher	higher	JJR	JJR	_	3	amod	_	_
2	NK	nk	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubjpass	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	predicted	predict	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	perception	perception	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	high	high	JJ	JJ	_	14	amod	_	_
12	quality	quality	NN	NN	_	14	compound	_	_
13	emotional	emotional	JJ	JJ	_	14	amod	_	_
14	support	support	NN	NN	_	9	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	spouse	spouse	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	intimate	intimate	JJ	JJ	_	20	amod	_	_
20	other	other	JJ	JJ	_	17	conj	_	_
21	,	,	,	,	_	9	punct	_	_
22	perceived	perceive	VBN	VBN	_	24	amod	_	_
23	social	social	JJ	JJ	_	24	amod	_	_
24	support	support	NN	NN	_	9	conj	_	_
25	from	from	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	patient	patient	NN	NN	_	29	nmod:poss	_	_
28	's	's	POS	POS	_	29	case	_	_
29	physician	physician	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	9	punct	_	_
31	estrogen	estrogen	NN	NN	_	32	nmod:npmod	_	_
32	receptor-negative	receptor-negative	JJ	JJ	_	34	amod	_	_
33	tumor	tumor	NN	NN	_	34	compound	_	_
34	status	status	NN	NN	_	9	conj	_	_
35	,	,	,	,	_	9	punct	_	_
36	having	have	VBG	VBG	_	9	conj	_	_
37	an	a	DT	DT	_	39	det	_	_
38	excisional	excisional	JJ	JJ	_	39	amod	_	_
39	biopsy	biopsy	NN	NN	_	36	dobj	_	_
40	as	as	IN	IN	_	42	case	_	_
41	surgical	surgical	JJ	JJ	_	42	amod	_	_
42	treatment	treatment	NN	NN	_	36	nmod	_	_
43	,	,	,	,	_	9	punct	_	_
44	and	and	CC	CC	_	9	cc	_	_
45	actively	actively	RB	RB	_	46	advmod	_	_
46	seeking	seek	VBG	VBG	_	9	conj	_	_
47	social	social	JJ	JJ	_	48	amod	_	_
48	support	support	NN	NN	_	46	dobj	_	_
49	as	as	IN	IN	_	53	case	_	_
50	a	a	DT	DT	_	53	det	_	_
51	major	major	JJ	JJ	_	53	amod	_	_
52	coping	coping	NN	NN	_	53	compound	_	_
53	strategy	strategy	NN	NN	_	46	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	R2	r2	NN	NN	_	6	dep	_	_
56	=	=	JJ	JJ	_	55	amod	_	_
57	0.33	0.33	CD	CD	_	56	dep	_	_
58	,	,	,	,	_	55	punct	_	_
59	F	f	NN	NN	_	55	appos	_	_
60	(	(	-LRB-	-LRB-	_	63	punct	_	_
61	5	5	CD	CD	_	63	compound	_	_
62	,	,	,	,	_	63	punct	_	_
63	55	55	CD	CD	_	59	dep	_	_
64	)	)	-RRB-	-RRB-	_	63	punct	_	_
65	=	=	JJ	JJ	_	59	amod	_	_
66	5.5	5.5	CD	CD	_	65	dep	_	_
67	,	,	,	,	_	55	punct	_	_
68	p	p	NN	NN	_	55	appos	_	_
69	less	less	JJR	JJR	_	68	amod	_	_
70	than	than	IN	IN	_	71	case	_	_
71	0.0004	0.0004	CD	CD	_	69	nmod	_	_
72	)	)	-RRB-	-RRB-	_	55	punct	_	_
73	.	.	.	.	_	6	punct	_	_

1	Findings	finding	NNS	NNS	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	discussed	discuss	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	terms	term	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	host	host	NN	NN	_	8	compound	_	_
8	interaction	interaction	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	tumor	tumor	NN	NN	_	12	compound	_	_
11	endocrine	endocrine	JJ	JJ	_	12	amod	_	_
12	status	status	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	8	conj	_	_
17	that	that	WDT	WDT	_	21	dobj	_	_
18	social	social	JJ	JJ	_	19	amod	_	_
19	support	support	NN	NN	_	21	nsubj	_	_
20	might	might	MD	MD	_	21	aux	_	_
21	play	play	VB	VB	_	16	acl:relcl	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	modulating	modulate	VBG	VBG	_	21	advcl	_	_
24	such	such	JJ	JJ	_	25	amod	_	_
25	activity	activity	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Octamer	octamer	NN	NN	_	3	compound	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	11	det	_	_
6	cell	cell	NN	NN	_	10	compound	_	_
7	type-specificity	type-specificity	NN	NN	_	10	compound	_	_
8	of	of	IN	IN	_	10	amod	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	3	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	produced	produce	VBN	VBN	_	0	root	_	_
4	exclusively	exclusively	RB	RB	_	7	advmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	antibody-encoding	antibody-encoding	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	13	det	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	Ig	ig	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	genes	gene	NNS	NNS	_	6	appos	_	_
14	,	,	,	,	_	2	punct	_	_
15	is	be	VBZ	VBZ	_	17	aux	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	restricted	restricted	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	octamer	octamer	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	ATGCAAAT	atgcaaat	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	enhancer	enhancer	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Ig	ig	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	plays	play	VBZ	VBZ	_	6	conj	_	_
19	an	a	DT	DT	_	21	det	_	_
20	important	important	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	tissue-specific	tissue-specific	JJ	JJ	_	25	amod	_	_
25	expression	expression	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	motif	motif	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	site	site	NN	NN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	the	the	DT	DT	_	16	det	_	_
13	so-called	so-called	JJ	JJ	_	16	amod	_	_
14	octamer	octamer	NN	NN	_	16	compound	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	10	appos	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Oct	oct	NN	NN	_	16	dep	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	OTF	otf	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	conj	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Oct-1	oct-1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	present	present	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	all	all	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	types	type	NNS	NNS	_	5	nmod	_	_
10	analyzed	analyze	VBN	VBN	_	9	acl	_	_
11	so	so	RB	RB	_	12	advmod	_	_
12	far	far	RB	RB	_	10	advmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	whereas	whereas	IN	IN	_	19	mark	_	_
15	Oct-2A	oct-2a	NN	NN	_	19	nsubjpass	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Oct-2B	oct-2b	NN	NN	_	15	conj	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	5	advcl	_	_
20	mainly	mainly	RB	RB	_	23	advmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	dep	_	_
6	same	same	JJ	JJ	_	8	amod	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	specificity	specificity	NN	NN	_	4	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	affinity	affinity	NN	NN	_	8	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	12	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Ig	ig	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
13	at	at	IN	IN	_	16	advmod	_	_
14	least	least	JJS	JJS	_	13	mwe	_	_
15	in	in	IN	IN	_	16	case	_	_
16	part	part	NN	NN	_	12	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	cell	cell	NN	NN	_	12	nmod	_	_
19	type-specific	type-specific	JJ	JJ	_	21	amod	_	_
20	Oct	oct	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	dep	_	_
22	,	,	,	,	_	12	punct	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	that	that	IN	IN	_	26	mark	_	_
25	there	there	EX	EX	_	26	expl	_	_
26	are	be	VBP	VBP	_	12	conj	_	_
27	both	both	CC	CC	_	28	cc:preconj	_	_
28	quantitative	quantitative	JJ	JJ	_	26	nsubj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	qualitative	qualitative	JJ	JJ	_	28	conj	_	_
31	differences	difference	NNS	NNS	_	28	dep	_	_
32	between	between	IN	IN	_	33	case	_	_
33	Oct-1	oct-1	NN	NN	_	26	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Oct-2	oct-2	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	33	conj	_	_
37	.	.	.	.	_	2	punct	_	_

1	Recently	recently	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	number	number	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	other	other	JJ	JJ	_	9	amod	_	_
7	octamer	octamer	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	variants	variant	NNS	NNS	_	4	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Many	many	JJ	JJ	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	created	create	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	alternative	alternative	JJ	JJ	_	9	amod	_	_
9	splicing	splicing	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	primary	primary	JJ	JJ	_	13	amod	_	_
13	transcript	transcript	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	one	one	CD	CD	_	18	nummod	_	_
16	Oct	oct	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	6	cc	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	serve	serve	VB	VB	_	6	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	specific	specific	JJ	JJ	_	24	amod	_	_
24	function	function	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	fine	fine	JJ	JJ	_	28	amod	_	_
28	tuning	tuning	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	eight	eight	CD	CD	_	4	nummod	_	_
4	families	family	NNS	NNS	_	1	nmod	_	_
5	:	:	:	:	_	1	punct	_	_
6	different	different	JJ	JJ	_	7	amod	_	_
7	forms	form	NNS	NNS	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	inheritance	inheritance	NN	NN	_	7	nmod	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	evidence	evidence	NN	NN	_	1	dep	_	_
12	for	for	IN	IN	_	15	case	_	_
13	various	various	JJ	JJ	_	15	amod	_	_
14	genetic	genetic	JJ	JJ	_	15	amod	_	_
15	defects	defect	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	rare	rare	JJ	JJ	_	6	amod	_	_
5	hereditary	hereditary	JJ	JJ	_	6	amod	_	_
6	disorder	disorder	NN	NN	_	0	root	_	_
7	presenting	present	VBG	VBG	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	infancy	infancy	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	renal	renal	JJ	JJ	_	14	amod	_	_
13	salt	salt	NN	NN	_	14	compound	_	_
14	loss	loss	NN	NN	_	7	nmod	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	17	case	_	_
17	hyponatremia	hyponatremia	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	hyperkalemia	hyperkalemia	NN	NN	_	17	conj	_	_
20	despite	despite	IN	IN	_	22	case	_	_
21	high	high	JJ	JJ	_	22	amod	_	_
22	levels	level	NNS	NNS	_	7	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	plasma	plasma	NN	NN	_	25	compound	_	_
25	aldosterone	aldosterone	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	insensitive	insensitive	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	mineralocorticoids	mineralocorticoid	NNS	NNS	_	4	nmod	_	_
7	;	;	:	:	_	4	punct	_	_
8	however	however	RB	RB	_	13	advmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	supplementation	supplementation	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	able	able	JJ	JJ	_	4	parataxis	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	correct	correct	VB	VB	_	13	xcomp	_	_
16	electrolyte	electrolyte	NN	NN	_	17	compound	_	_
17	abnormalities	abnormality	NNS	NNS	_	15	dobj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Absent	absent	JJ	JJ	_	16	nsubjpass	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	greatly	greatly	RB	RB	_	4	advmod	_	_
4	diminished	diminish	VBN	VBN	_	5	amod	_	_
5	type	type	NN	NN	_	1	conj	_	_
6	I	i	CD	CD	_	8	nummod	_	_
7	aldosterone	aldosterone	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leucocytes	leucocyte	NNS	NNS	_	1	nmod	_	_
13	have	have	VBP	VBP	_	16	aux	_	_
14	been	be	VBN	VBN	_	16	auxpass	_	_
15	recently	recently	RB	RB	_	16	advmod	_	_
16	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	explain	explain	VB	VB	_	16	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	lack	lack	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	response	response	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	mineralocorticoids	mineralocorticoid	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mode	mode	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	inheritance	inheritance	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	eight	eight	CD	CD	_	10	nummod	_	_
10	families	family	NNS	NNS	_	5	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	total	total	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	nine	nine	CD	CD	_	16	nummod	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	nsubj	_	_
4	for	for	IN	IN	_	8	case	_	_
5	an	a	DT	DT	_	8	det	_	_
6	autosomal	autosomal	JJ	JJ	_	8	amod	_	_
7	recessive	recessive	JJ	JJ	_	8	amod	_	_
8	form	form	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	inheritance	inheritance	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	four	four	CD	CD	_	13	nummod	_	_
13	families	family	NNS	NNS	_	2	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	while	while	IN	IN	_	20	mark	_	_
16	the	the	DT	DT	_	19	det	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	four	four	CD	CD	_	19	nummod	_	_
19	families	family	NNS	NNS	_	20	nsubj	_	_
20	appeared	appear	VBD	VBD	_	2	advcl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	have	have	VB	VB	_	20	xcomp	_	_
23	an	a	DT	DT	_	26	det	_	_
24	autosomal	autosomal	JJ	JJ	_	26	amod	_	_
25	dominant	dominant	JJ	JJ	_	26	amod	_	_
26	mode	mode	NN	NN	_	22	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	transmission	transmission	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	families	family	NNS	NNS	_	9	nmod	_	_
4	the	the	DT	DT	_	7	det	_	_
5	autosomal	autosomal	JJ	JJ	_	7	amod	_	_
6	recessive	recessive	JJ	JJ	_	7	amod	_	_
7	form	form	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	characterized	characterize	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	receptor	receptor	NN	NN	_	9	nmod	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	hormone	hormone	NN	NN	_	17	compound	_	_
17	data	datum	NNS	NNS	_	12	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	both	both	DT	DT	_	20	det	_	_
20	parents	parent	NNS	NNS	_	12	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	while	while	IN	IN	_	33	mark	_	_
23	in	in	IN	IN	_	25	case	_	_
24	one	one	CD	CD	_	25	nummod	_	_
25	family	family	NN	NN	_	33	nmod	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	33	nsubjpass	_	_
28	in	in	IN	IN	_	30	case	_	_
29	both	both	DT	DT	_	30	det	_	_
30	parents	parent	NNS	NNS	_	27	nmod	_	_
31	were	be	VBD	VBD	_	33	auxpass	_	_
32	greatly	greatly	RB	RB	_	33	advmod	_	_
33	reduced	reduce	VBN	VBN	_	9	advcl	_	_
34	,	,	,	,	_	33	punct	_	_
35	but	but	CC	CC	_	33	cc	_	_
36	hormone	hormone	NN	NN	_	37	compound	_	_
37	levels	level	NNS	NNS	_	39	nsubj	_	_
38	were	be	VBD	VBD	_	39	cop	_	_
39	normal	normal	JJ	JJ	_	33	conj	_	_
40	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	four	four	CD	CD	_	4	nummod	_	_
4	families	family	NNS	NNS	_	16	nmod	_	_
5	with	with	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	autosomal	autosomal	JJ	JJ	_	9	amod	_	_
8	dominant	dominant	JJ	JJ	_	9	amod	_	_
9	mode	mode	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	transmission	transmission	NN	NN	_	9	nmod	_	_
12	there	there	RB	RB	_	16	nsubj	_	_
13	was	be	VBD	VBD	_	16	cop	_	_
14	always	always	RB	RB	_	16	advmod	_	_
15	one	one	CD	CD	_	16	nummod	_	_
16	parent	parent	NN	NN	_	0	root	_	_
17	with	with	IN	IN	_	20	case	_	_
18	reduced	reduce	VBN	VBN	_	20	amod	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
23	mononuclear	mononuclear	JJ	JJ	_	24	amod	_	_
24	leucocytes	leucocyte	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	elevated	elevated	JJ	JJ	_	29	amod	_	_
27	serum	serum	NN	NN	_	29	compound	_	_
28	hormone	hormone	NN	NN	_	29	compound	_	_
29	levels	level	NNS	NNS	_	20	conj	_	_
30	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	parents	parent	NNS	NNS	_	5	nsubj	_	_
3	were	be	VBD	VBD	_	5	cop	_	_
4	entirely	entirely	RB	RB	_	5	advmod	_	_
5	asymptomatic	asymptomatic	JJ	JJ	_	0	root	_	_
6	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	an	a	DT	DT	_	4	det	_	_
3	extended	extend	VBN	VBN	_	4	amod	_	_
4	family	family	NN	NN	_	7	nmod	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	study	study	VB	VB	_	7	xcomp	_	_
10	an	a	DT	DT	_	11	det	_	_
11	aunt	aunt	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	her	she	PRP$	PRP$	_	15	nmod:poss	_	_
14	newborn	newborn	JJ	JJ	_	15	amod	_	_
15	daughter	daughter	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	who	who	WP	WP	_	22	nsubjpass	_	_
18	were	be	VBD	VBD	_	22	auxpass	_	_
19	both	both	DT	DT	_	22	cc:preconj	_	_
20	also	also	RB	RB	_	22	advmod	_	_
21	biochemically	biochemically	RB	RB	_	22	advmod	_	_
22	affected	affect	VBN	VBN	_	11	acl:relcl	_	_
23	but	but	CC	CC	_	22	cc	_	_
24	clinically	clinically	RB	RB	_	25	advmod	_	_
25	asymptomatic	asymptomatic	JJ	JJ	_	22	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	5	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	this	this	DT	DT	_	9	det	_	_
8	dual	dual	JJ	JJ	_	9	amod	_	_
9	pattern	pattern	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	genetic	genetic	JJ	JJ	_	12	amod	_	_
12	transmission	transmission	NN	NN	_	9	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	indicate	indicate	VB	VB	_	5	ccomp	_	_
15	differing	differ	VBG	VBG	_	17	amod	_	_
16	genetic	genetic	JJ	JJ	_	17	amod	_	_
17	defects	defect	NNS	NNS	_	14	dobj	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	cause	cause	VBP	VBP	_	17	acl:relcl	_	_
20	the	the	DT	DT	_	23	det	_	_
21	same	same	JJ	JJ	_	23	amod	_	_
22	clinical	clinical	JJ	JJ	_	23	amod	_	_
23	picture	picture	NN	NN	_	19	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Steroid	steroid	NN	NN	_	3	compound	_	_
2	mediated	mediated	JJ	JJ	_	3	amod	_	_
3	lysis	lysis	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	lymphoblasts	lymphoblast	NNS	NNS	_	3	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	steroid	steroid	NN	NN	_	15	compound	_	_
14	hormone	hormone	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	2	nsubj	_	_
2	kill	kill	VBP	VBP	_	0	root	_	_
3	certain	certain	JJ	JJ	_	4	amod	_	_
4	types	type	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	lymphoblasts	lymphoblast	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	but	but	CC	CC	_	2	cc	_	_
9	the	the	DT	DT	_	10	det	_	_
10	mechanisms	mechanism	NNS	NNS	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	unknown	unknown	JJ	JJ	_	2	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	clear	clear	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	sufficient	sufficient	JJ	JJ	_	6	amod	_	_
6	numbers	number	NNS	NNS	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	functional	functional	JJ	JJ	_	10	amod	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	6	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	3	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	mediate	mediate	VB	VB	_	12	xcomp	_	_
15	lysis	lysis	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	3	punct	_	_
17	but	but	CC	CC	_	3	cc	_	_
18	whether	whether	IN	IN	_	20	mark	_	_
19	they	they	PRP	PRP	_	20	nsubj	_	_
20	do	do	VBP	VBP	_	38	csubjpass	_	_
21	so	so	RB	RB	_	20	advmod	_	_
22	through	through	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	classical	classical	JJ	JJ	_	25	amod	_	_
25	model	model	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	steroid	steroid	NN	NN	_	29	compound	_	_
28	hormone	hormone	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	25	cc	_	_
31	modulation	modulation	NN	NN	_	25	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	nmod	_	_
35	has	have	VBZ	VBZ	_	38	aux	_	_
36	not	not	RB	RB	_	38	neg	_	_
37	been	be	VBN	VBN	_	38	auxpass	_	_
38	established	establish	VBN	VBN	_	3	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	asked	ask	VBN	VBN	_	0	root	_	_
7	which	which	WDT	WDT	_	10	det	_	_
8	region	region	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	s	s	NNS	NNS	_	17	nsubj	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	steroid	steroid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	10	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	important	important	JJ	JJ	_	6	ccomp	_	_
18	for	for	IN	IN	_	19	mark	_	_
19	mediating	mediate	VBG	VBG	_	17	advcl	_	_
20	lysis	lysis	NN	NN	_	19	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphoblasts	lymphoblast	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	CEM-ICR	cem-icr	NN	NN	_	4	compound	_	_
2	27	27	CD	CD	_	4	nummod	_	_
3	leukemic	leukemic	JJ	JJ	_	4	amod	_	_
4	lymphoblasts	lymphoblast	NNS	NNS	_	32	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	clone	clone	NN	NN	_	4	appos	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CEM	cem	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	lack	lack	VBP	VBP	_	7	acl:relcl	_	_
13	functional	functional	JJ	JJ	_	15	amod	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	12	dobj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	therefore	therefore	RB	RB	_	18	advmod	_	_
18	are	be	VBP	VBP	_	12	conj	_	_
19	neither	neither	CC	CC	_	18	dep	_	_
20	lysed	lyse	VBN	VBN	_	18	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	dexamethasone	dexamethasone	NN	NN	_	20	nmod	_	_
23	nor	nor	CC	CC	_	20	cc	_	_
24	capable	capable	JJ	JJ	_	20	conj	_	_
25	of	of	IN	IN	_	26	mark	_	_
26	showing	show	VBG	VBG	_	24	advcl	_	_
27	glutamine	glutamine	NN	NN	_	28	compound	_	_
28	synthetase	synthetase	NN	NN	_	29	compound	_	_
29	induction	induction	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	4	punct	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	provided	provide	VBN	VBN	_	0	root	_	_
33	with	with	IN	IN	_	35	case	_	_
34	steroid	steroid	NN	NN	_	35	compound	_	_
35	receptors	receptor	NNS	NNS	_	32	nmod	_	_
36	by	by	IN	IN	_	38	case	_	_
37	DNA	dna	NN	NN	_	38	compound	_	_
38	transfections	transfection	NNS	NNS	_	32	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	various	various	JJ	JJ	_	43	amod	_	_
41	receptor	receptor	NN	NN	_	43	compound	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	constructs	construct	NNS	NNS	_	38	nmod	_	_
44	.	.	.	.	_	32	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	steroid	steroid	NN	NN	_	5	compound	_	_
4	mediated	mediated	JJ	JJ	_	5	amod	_	_
5	lysis	lysis	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	number	number	NN	NN	_	5	conj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	induction	induction	NN	NN	_	5	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glutamine	glutamine	NN	NN	_	13	compound	_	_
13	synthetase	synthetase	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transfected	transfect	VBN	VBN	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	5	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	lysis	lysis	NN	NN	_	8	compound	_	_
8	mechanism	mechanism	NN	NN	_	14	nsubjpass	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ICR27	icr27	NN	NN	_	12	compound	_	_
12	lymphoblasts	lymphoblast	NNS	NNS	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	restored	restore	VBN	VBN	_	4	ccomp	_	_
15	when	when	WRB	WRB	_	20	advmod	_	_
16	functional	functional	JJ	JJ	_	18	amod	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	number	number	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	restored	restore	VBN	VBN	_	14	advcl	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	12	nsubjpass	_	_
5	specifying	specify	VBG	VBG	_	4	acl	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	affinity	affinity	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	GRE	gre	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Lysis	lysis	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	mediated	mediate	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	any	any	DT	DT	_	6	det	_	_
6	steroid	steroid	NN	NN	_	3	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	allows	allow	VBZ	VBZ	_	6	acl:relcl	_	_
9	for	for	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	receptor	receptor	NN	NN	_	10	nmod	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	such	such	JJ	JJ	_	17	amod	_	_
16	a	a	DT	DT	_	17	det	_	_
17	region	region	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	view	view	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	steroid-mediated	steroid-mediated	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	death	death	NN	NN	_	10	nsubj	_	_
10	occurs	occur	VBZ	VBZ	_	5	ccomp	_	_
11	by	by	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	process	process	NN	NN	_	10	nmod	_	_
14	requiring	require	VBG	VBG	_	13	acl	_	_
15	direct	direct	JJ	JJ	_	16	amod	_	_
16	interaction	interaction	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	steroid-receptor	steroid-receptor	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	16	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	genome	genome	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
5	tat	tat	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	Jurkat	jurkat	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	using	use	VBG	VBG	_	2	dep	_	_
13	a	a	DT	DT	_	16	det	_	_
14	BK	bk	NN	NN	_	16	compound	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	vector	vector	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	production	production	NN	NN	_	38	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	characterization	characterization	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	Jurkat	jurkat	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	2	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	express	express	VBP	VBP	_	8	dep	_	_
12	functional	functional	JJ	JJ	_	23	amod	_	_
13	human	human	JJ	JJ	_	23	amod	_	_
14	immune	immune	JJ	JJ	_	23	amod	_	_
15	deficiency	deficiency	NN	NN	_	23	compound	_	_
16	virus	virus	NN	NN	_	23	compound	_	_
17	type	type	NN	NN	_	23	compound	_	_
18	1	1	CD	CD	_	23	nummod	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	HIV-1	hiv-1	NN	NN	_	23	compound	_	_
21	)	)	-RRB-	-RRB-	_	23	punct	_	_
22	tat	tat	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	11	dobj	_	_
24	,	,	,	,	_	2	punct	_	_
25	using	use	VBG	VBG	_	2	dep	_	_
26	a	a	DT	DT	_	31	det	_	_
27	BK	bk	NN	NN	_	31	compound	_	_
28	virus	virus	NN	NN	_	31	compound	_	_
29	plasmid	plasmid	NN	NN	_	31	compound	_	_
30	expression	expression	NN	NN	_	31	compound	_	_
31	vector	vector	NN	NN	_	25	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	HIV-1	hiv-1	NN	NN	_	35	compound	_	_
34	tat	tat	NN	NN	_	35	compound	_	_
35	cDNA	cdna	NN	NN	_	31	conj	_	_
36	,	,	,	,	_	2	punct	_	_
37	is	be	VBZ	VBZ	_	38	auxpass	_	_
38	described	describe	VBN	VBN	_	0	root	_	_
39	.	.	.	.	_	38	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	increased	increase	VBN	VBN	_	4	amod	_	_
3	growth	growth	NN	NN	_	4	compound	_	_
4	rate	rate	NN	NN	_	17	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	these	these	DT	DT	_	9	det	_	_
7	Jurkat-tat	jurkat-tat	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	4	nmod	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	compared	compare	VBN	VBN	_	4	dep	_	_
12	with	with	IN	IN	_	15	case	_	_
13	control	control	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	observed	observe	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Tax-independent	tax-independent	JJ	JJ	_	2	amod	_	_
2	binding	binding	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	multiple	multiple	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	Tax-response	tax-response	JJ	JJ	_	10	amod	_	_
9	element	element	NN	NN	_	10	compound	_	_
10	DNA	dna	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HTLV-I	htlv-i	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	11	det	_	_
2	human	human	JJ	JJ	_	11	amod	_	_
3	T-cell	t-cell	NN	NN	_	11	compound	_	_
4	leukemia	leukemia	NN	NN	_	11	compound	_	_
5	virus	virus	NN	NN	_	11	compound	_	_
6	type	type	NN	NN	_	11	compound	_	_
7	I	i	CD	CD	_	11	nummod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	promoter	promoter	NN	NN	_	12	nsubj	_	_
12	contains	contain	VBZ	VBZ	_	0	root	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	copies	copy	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	imperfect	imperfect	JJ	JJ	_	17	amod	_	_
17	repeats	repeat	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	21-base	21-base	JJ	JJ	_	22	amod	_	_
21	pair	pair	NN	NN	_	22	compound	_	_
22	sequence	sequence	NN	NN	_	17	nmod	_	_
23	designated	designate	VBN	VBN	_	22	acl	_	_
24	here	here	RB	RB	_	23	advmod	_	_
25	as	as	IN	IN	_	26	case	_	_
26	TRE	tre	NN	NN	_	23	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	Tax-response	tax-response	JJ	JJ	_	29	amod	_	_
29	element	element	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	that	that	WDT	WDT	_	33	nsubj	_	_
32	is	be	VBZ	VBZ	_	33	cop	_	_
33	responsive	responsive	JJ	JJ	_	26	acl:relcl	_	_
34	to	to	TO	TO	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	virally	virally	RB	RB	_	39	advmod	_	_
37	encoded	encode	VBN	VBN	_	39	amod	_	_
38	transactivator	transactivator	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	33	nmod	_	_
40	Tax	tax	NN	NN	_	39	dep	_	_
41	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	separated	separate	VBN	VBN	_	3	conj	_	_
6	four	four	CD	CD	_	8	nummod	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	3	dobj	_	_
9	from	from	IN	IN	_	11	case	_	_
10	C81-66-45	c81-66-45	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	an	a	DT	DT	_	19	det	_	_
14	HTLV-I	htlv-i	NN	NN	_	19	compound	_	_
15	immortalized	immortalized	JJ	JJ	_	19	amod	_	_
16	Tax-expressing	tax-express	VBG	VBG	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T-lymphocyte	t-lymphocyte	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	11	appos	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Salahuddin	Salahuddin	NNP	NNP	_	3	dep	_	_
22	et	et	FW	FW	_	21	compound	_	_
23	al.	al.	FW	FW	_	21	dep	_	_
24	,	,	,	,	_	21	punct	_	_
25	1983	1983	CD	CD	_	21	amod	_	_
26	)	)	-RRB-	-RRB-	_	21	punct	_	_
27	,	,	,	,	_	3	punct	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	interact	interact	VBP	VBP	_	3	dep	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	TRE-DNA	tre-dna	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	3	punct	_	_
34	none	none	NN	NN	_	38	nsubj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	which	which	WDT	WDT	_	34	acl	_	_
37	are	be	VBP	VBP	_	38	cop	_	_
38	identical	identical	JJ	JJ	_	3	dep	_	_
39	with	with	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	Tax-protein	tax-protein	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	4	nsubj	_	_
3	identified	identify	VBN	VBN	_	2	acl	_	_
4	have	have	VBP	VBP	_	0	root	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	weights	weight	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	about	about	RB	RB	_	9	advmod	_	_
9	32	32	CD	CD	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	36	36	CD	CD	_	13	compound	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	42	42	CD	CD	_	9	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	50	50	CD	CD	_	9	conj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	110	110	CD	CD	_	9	conj	_	_
18	kD	kd	NN	NN	_	9	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	Four	four	CD	CD	_	3	nummod	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	methods	method	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	used	use	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	identify	identify	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	proteins	protein	NNS	NNS	_	7	dobj	_	_
10	.	.	.	.	_	5	punct	_	_

1	First	first	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	from	from	IN	IN	_	6	case	_	_
4	different	different	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	17	nmod	_	_
7	three	three	CD	CD	_	17	nsubjpass	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	all	all	DT	DT	_	10	det	_	_
10	four	four	CD	CD	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	7	nmod	_	_
15	were	be	VBD	VBD	_	17	auxpass	_	_
16	specifically	specifically	RB	RB	_	17	xcomp	_	_
17	cross-linked	cross-link	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	20	case	_	_
19	UV	uv	NN	NN	_	20	compound	_	_
20	irradiation	irradiation	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	radioactively	radioactively	RB	RB	_	24	advmod	_	_
24	labeled	label	VBN	VBN	_	26	amod	_	_
25	TRE-DNA	tre-dna	NN	NN	_	26	compound	_	_
26	fragment	fragment	NN	NN	_	17	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Second	second	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	TRE-DNA	tre-dna	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	6	nsubj	_	_
6	sedimented	sediment	VBD	VBD	_	0	root	_	_
7	through	through	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	glycerol	glycerol	NN	NN	_	11	compound	_	_
10	density	density	NN	NN	_	11	compound	_	_
11	gradient	gradient	NN	NN	_	6	nmod	_	_
12	at	at	IN	IN	_	13	case	_	_
13	rates	rate	NNS	NNS	_	6	nmod	_	_
14	corresponding	correspond	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	16	case	_	_
16	proteins	protein	NNS	NNS	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	native	native	JJ	JJ	_	20	amod	_	_
19	molecular	molecular	JJ	JJ	_	20	amod	_	_
20	weights	weight	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	35	35	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	50	50	CD	CD	_	25	nummod	_	_
25	kD	kd	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	110	110	CD	CD	_	28	nummod	_	_
28	kD	kd	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Third	third	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	only	only	RB	RB	_	7	advmod	_	_
4	the	the	DT	DT	_	7	det	_	_
5	50	50	CD	CD	_	7	nummod	_	_
6	kD	kd	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	retained	retain	VBN	VBN	_	0	root	_	_
10	on	on	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	biotinylated	biotinylate	VBN	VBN	_	14	amod	_	_
13	DNA-streptavidin	dna-streptavidin	NN	NN	_	14	compound	_	_
14	matrix	matrix	NN	NN	_	9	nmod	_	_
15	when	when	WRB	WRB	_	19	advmod	_	_
16	the	the	DT	DT	_	18	det	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	fragment	fragment	NN	NN	_	19	nsubj	_	_
19	contained	contain	VBD	VBD	_	9	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	TRE-DNA	tre-dna	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Fourth	fourth	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	extensive	extensive	JJ	JJ	_	4	amod	_	_
4	purification	purification	NN	NN	_	12	nsubj	_	_
5	by	by	IN	IN	_	7	case	_	_
6	several	several	JJ	JJ	_	7	amod	_	_
7	cycles	cycle	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	TRE-DNA	tre-dna	JJ	JJ	_	11	amod	_	_
10	affinity	affinity	NN	NN	_	11	compound	_	_
11	chromatography	chromatography	NN	NN	_	7	nmod	_	_
12	resulted	result	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	32	32	CD	CD	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	36	36	CD	CD	_	19	compound	_	_
18	to	to	TO	TO	_	19	dep	_	_
19	42	42	CD	CD	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	110	110	CD	CD	_	15	conj	_	_
22	kD	kd	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	15	dep	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	to	to	TO	TO	_	26	case	_	_
26	less	less	JJR	JJR	_	15	conj	_	_
27	extent	extent	NN	NN	_	26	dep	_	_
28	the	the	DT	DT	_	31	det	_	_
29	50	50	CD	CD	_	31	nummod	_	_
30	kD	kd	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	15	dep	_	_
32	.	.	.	.	_	12	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	abundant	abundant	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	75	75	CD	CD	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	80	80	CD	CD	_	5	conj	_	_
8	kD	kd	NN	NN	_	5	dep	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	competed	compete	VBN	VBN	_	0	root	_	_
11	out	out	RP	RP	_	10	compound:prt	_	_
12	by	by	IN	IN	_	13	case	_	_
13	poly-LSB-d(I-C)-RSB-	poly-lsb-d(i-c)-rsb-	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	all	all	DT	DT	_	16	det	_	_
16	reactions	reaction	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cAMP-response	camp-response	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	15	nsubj	_	_
4	CRE	cre	NN	NN	_	3	dep	_	_
5	,	,	,	,	_	3	punct	_	_
6	TGACGTCA	tgacgtca	NN	NN	_	3	appos	_	_
7	,	,	,	,	_	3	punct	_	_
8	present	present	JJ	JJ	_	3	amod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	21	21	CD	CD	_	13	nummod	_	_
12	base-pair	base-pair	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	appears	appear	VBZ	VBZ	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	essential	essential	JJ	JJ	_	15	xcomp	_	_
19	for	for	IN	IN	_	22	case	_	_
20	specific	specific	JJ	JJ	_	22	amod	_	_
21	protein-TRE-DNA	protein-tre-dna	JJ	JJ	_	22	amod	_	_
22	interactions	interaction	NNS	NNS	_	18	nmod	_	_
23	because	because	IN	IN	_	30	mark	_	_
24	mutation	mutation	NN	NN	_	30	nsubj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	two	two	CD	CD	_	29	nummod	_	_
28	G	g	NN	NN	_	29	compound	_	_
29	's	'	NNS	NNS	_	24	nmod	_	_
30	destroys	destroy	VBZ	VBZ	_	15	advcl	_	_
31	this	this	DT	DT	_	32	det	_	_
32	complex	complex	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	cAMP	camp	NN	NN	_	10	compound	_	_
7	response	response	NN	NN	_	10	compound	_	_
8	element	element	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	15	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	CREB	creb	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	3	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	protein-TRE-DNA	protein-tre-dna	JJ	JJ	_	19	amod	_	_
19	complex	complex	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	in	in	IN	IN	_	25	mark	_	_
22	mediating	mediate	VBG	VBG	_	25	amod	_	_
23	the	the	DT	DT	_	25	det	_	_
24	Tax	tax	NN	NN	_	25	compound	_	_
25	response	response	NN	NN	_	19	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Risk	risk	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	0	root	_	_
3	for	for	IN	IN	_	5	case	_	_
4	breast	breast	NN	NN	_	5	compound	_	_
5	recurrence	recurrence	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	premenopausal	premenopausal	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	postmenopausal	postmenopausal	JJ	JJ	_	7	conj	_	_
10	patients	patient	NNS	NNS	_	7	dep	_	_
11	with	with	IN	IN	_	13	case	_	_
12	ductal	ductal	JJ	JJ	_	13	amod	_	_
13	cancers	cancer	NNS	NNS	_	7	nmod	_	_
14	treated	treat	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	conservation	conservation	NN	NN	_	17	compound	_	_
17	therapy	therapy	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Risk	risk	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	7	nsubjpass	_	_
3	for	for	IN	IN	_	5	case	_	_
4	local	local	JJ	JJ	_	5	amod	_	_
5	failure	failure	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	evaluated	evaluate	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	13	case	_	_
9	496	496	CD	CD	_	13	nummod	_	_
10	clinical	clinical	JJ	JJ	_	13	amod	_	_
11	Stage	stage	NN	NN	_	13	compound	_	_
12	I-II	i-ii	CD	CD	_	13	nummod	_	_
13	patients	patient	NNS	NNS	_	7	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	infiltrating	infiltrating	JJ	JJ	_	17	amod	_	_
16	ductal	ductal	JJ	JJ	_	17	amod	_	_
17	carcinomas	carcinoma	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	median	median	NN	NN	_	20	compound	_	_
20	follow-up	follow-up	NN	NN	_	13	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	71	71	CD	CD	_	23	nummod	_	_
23	months	month	NNS	NNS	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	20	punct	_	_
25	treated	treat	VBN	VBN	_	13	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	conservative	conservative	JJ	JJ	_	28	amod	_	_
28	surgery	surgery	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	radiotherapy	radiotherapy	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	7	punct	_	_

1	Monofactorial	monofactorial	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	following	following	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	3	dobj	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	correlated	correlate	VBN	VBN	_	6	acl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	increased	increase	VBN	VBN	_	12	amod	_	_
12	risk	risk	NN	NN	_	9	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	moderate/marked	moderate/marked	JJ	JJ	_	17	amod	_	_
15	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	reaction	reaction	NN	NN	_	3	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	MCR	mcr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	17	punct	_	_
22	high	high	JJ	JJ	_	24	amod	_	_
23	histologic	histologic	JJ	JJ	_	24	amod	_	_
24	grade	grade	NN	NN	_	17	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	G	g	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	17	punct	_	_
29	extensive	extensive	JJ	JJ	_	31	amod	_	_
30	intraductal	intraductal	JJ	JJ	_	31	amod	_	_
31	component	component	NN	NN	_	17	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	EIC	eic	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	17	punct	_	_
36	tumor	tumor	NN	NN	_	37	compound	_	_
37	necrosis	necrosis	NN	NN	_	17	conj	_	_
38	,	,	,	,	_	17	punct	_	_
39	macroscopic	macroscopic	JJ	JJ	_	40	amod	_	_
40	multiplicity	multiplicity	NN	NN	_	17	conj	_	_
41	,	,	,	,	_	17	punct	_	_
42	estrogen	estrogen	NN	NN	_	43	compound	_	_
43	receptor	receptor	NN	NN	_	44	compound	_	_
44	negativity	negativity	NN	NN	_	17	conj	_	_
45	,	,	,	,	_	17	punct	_	_
46	anatomic	anatomic	JJ	JJ	_	48	amod	_	_
47	tumor	tumor	NN	NN	_	48	compound	_	_
48	size	size	NN	NN	_	17	conj	_	_
49	,	,	,	,	_	17	punct	_	_
50	age	age	NN	NN	_	17	conj	_	_
51	younger	younger	JJR	JJR	_	50	amod	_	_
52	than	than	IN	IN	_	54	case	_	_
53	40	40	CD	CD	_	54	nummod	_	_
54	years	year	NNS	NNS	_	51	nmod	_	_
55	,	,	,	,	_	17	punct	_	_
56	and	and	CC	CC	_	17	cc	_	_
57	vascular	vascular	JJ	JJ	_	58	amod	_	_
58	invasion	invasion	NN	NN	_	17	conj	_	_
59	.	.	.	.	_	3	punct	_	_

1	Only	only	RB	RB	_	2	advmod	_	_
2	MCR	mcr	NN	NN	_	8	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	G	g	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	EIC	eic	NN	NN	_	2	conj	_	_
8	proved	prove	VBD	VBD	_	0	root	_	_
9	significant	significant	JJ	JJ	_	8	xcomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Cox	cox	NN	NN	_	13	compound	_	_
12	multivariate	multivariate	JJ	JJ	_	13	amod	_	_
13	analysis	analysis	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	risk	risk	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	7	nsubj	_	_
4	were	be	VBD	VBD	_	7	cop	_	_
5	highly	highly	RB	RB	_	7	advmod	_	_
6	age	age	NN	NN	_	7	nmod:npmod	_	_
7	dependent	dependent	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	with	with	IN	IN	_	13	mark	_	_
10	EIC	eic	NN	NN	_	13	dep	_	_
11	markedly	markedly	RB	RB	_	13	advmod	_	_
12	more	more	RBR	RBR	_	13	advmod	_	_
13	prevalent	prevalent	JJ	JJ	_	7	advcl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	women	woman	NNS	NNS	_	13	nmod	_	_
16	younger	younger	JJR	JJR	_	15	amod	_	_
17	than	than	IN	IN	_	18	case	_	_
18	50	50	CD	CD	_	16	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	MCR	mcr	NN	NN	_	13	parataxis	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	G	g	NN	NN	_	20	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	women	woman	NNS	NNS	_	20	nmod	_	_
25	younger	younger	JJR	JJR	_	24	amod	_	_
26	than	than	IN	IN	_	27	case	_	_
27	40	40	CD	CD	_	25	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Separate	separate	JJ	JJ	_	3	amod	_	_
2	Cox	cox	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	7	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	premenopausal	premenopausal	JJ	JJ	_	6	amod	_	_
6	patients	patient	NNS	NNS	_	3	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	MCR/EIC	mcr/eic	NN	NN	_	10	nsubj	_	_
10	determined	determine	VBD	VBD	_	7	ccomp	_	_
11	risk	risk	NN	NN	_	10	dobj	_	_
12	independent	independent	JJ	JJ	_	10	advmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	resection	resection	NN	NN	_	15	compound	_	_
15	margins	margin	NNS	NNS	_	12	nmod	_	_
16	:	:	:	:	_	7	punct	_	_
17	tumors	tumor	NNS	NNS	_	20	nsubj	_	_
18	with	with	IN	IN	_	19	case	_	_
19	MCR	mcr	NN	NN	_	17	nmod	_	_
20	had	have	VBD	VBD	_	7	parataxis	_	_
21	a	a	DT	DT	_	23	det	_	_
22	28	28	CD	CD	_	23	compound	_	_
23	%	%	NN	NN	_	20	dobj	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	with	with	IN	IN	_	27	case	_	_
27	EIC	eic	NN	NN	_	31	dep	_	_
28	a	a	DT	DT	_	31	det	_	_
29	22	22	CD	CD	_	30	compound	_	_
30	%	%	NN	NN	_	31	amod	_	_
31	probability	probability	NN	NN	_	20	conj	_	_
32	of	of	IN	IN	_	33	mark	_	_
33	recurring	recur	VBG	VBG	_	31	acl	_	_
34	locally	locally	RB	RB	_	33	xcomp	_	_
35	by	by	IN	IN	_	37	case	_	_
36	5	5	CD	CD	_	37	nummod	_	_
37	years	year	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	Premenopausal	premenopausal	JJ	JJ	_	2	amod	_	_
2	patients	patient	NNS	NNS	_	7	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	neither	neither	DT	DT	_	6	det	_	_
5	risk	risk	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	2	nmod	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	12	det	_	_
9	very	very	RB	RB	_	10	advmod	_	_
10	low	low	JJ	JJ	_	12	amod	_	_
11	failure	failure	NN	NN	_	12	compound	_	_
12	rate	rate	NN	NN	_	7	dobj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	2.6	2.6	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	12	dep	_	_
16	at	at	IN	IN	_	18	case	_	_
17	5	5	CD	CD	_	18	nummod	_	_
18	years	year	NNS	NNS	_	15	nmod	_	_
19	)	)	-RRB-	-RRB-	_	15	punct	_	_
20	,	,	,	,	_	7	punct	_	_
21	regardless	regardless	RB	RB	_	7	advmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	age	age	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	postmenopausal	postmenopausal	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	9	nmod	_	_
4	risk	risk	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	breast	breast	NN	NN	_	7	compound	_	_
7	recurrence	recurrence	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	determined	determine	VBN	VBN	_	0	root	_	_
10	both	both	CC	CC	_	9	dep	_	_
11	by	by	IN	IN	_	12	case	_	_
12	adequacy	adequacy	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	resection	resection	NN	NN	_	12	nmod	_	_
15	margins	margin	NNS	NNS	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	grade	grade	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	9	punct	_	_
19	with	with	IN	IN	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	high	high	JJ	JJ	_	24	amod	_	_
22	local	local	JJ	JJ	_	24	amod	_	_
23	failure	failure	NN	NN	_	24	compound	_	_
24	rate	rate	NN	NN	_	9	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	patients	patient	NNS	NNS	_	24	nmod	_	_
27	having	have	VBG	VBG	_	26	acl	_	_
28	G3	g3	NN	NN	_	29	compound	_	_
29	tumors	tumor	NNS	NNS	_	27	dobj	_	_
30	with	with	IN	IN	_	31	case	_	_
31	positive	positive	JJ	JJ	_	29	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	indeterminate	indeterminate	JJ	JJ	_	31	conj	_	_
34	margins	margin	NNS	NNS	_	31	dep	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	31	31	CD	CD	_	37	nummod	_	_
37	%	%	NN	NN	_	9	dep	_	_
38	at	at	IN	IN	_	40	case	_	_
39	5	5	CD	CD	_	40	nummod	_	_
40	years	year	NNS	NNS	_	37	nmod	_	_
41	)	)	-RRB-	-RRB-	_	37	punct	_	_
42	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	3	nsubj	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	microscopic	microscopic	JJ	JJ	_	7	amod	_	_
7	examination	examination	NN	NN	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	the	the	DT	DT	_	12	det	_	_
10	only	only	JJ	JJ	_	12	amod	_	_
11	useful	useful	JJ	JJ	_	12	amod	_	_
12	tool	tool	NN	NN	_	3	ccomp	_	_
13	for	for	IN	IN	_	14	mark	_	_
14	assessing	assess	VBG	VBG	_	12	acl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	risk	risk	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	local	local	JJ	JJ	_	19	amod	_	_
19	failure	failure	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	16	punct	_	_
21	which	which	WDT	WDT	_	24	nsubj	_	_
22	is	be	VBZ	VBZ	_	24	cop	_	_
23	quite	quite	RB	RB	_	24	advmod	_	_
24	low	low	JJ	JJ	_	16	acl:relcl	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	majority	majority	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	patients	patient	NNS	NNS	_	27	nmod	_	_
30	treated	treat	VBN	VBN	_	29	acl	_	_
31	with	with	IN	IN	_	33	case	_	_
32	breast	breast	NN	NN	_	33	compound	_	_
33	conservation	conservation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	High-risk	high-risk	JJ	JJ	_	2	amod	_	_
2	patients	patient	NNS	NNS	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	recognized	recognize	VBN	VBN	_	0	root	_	_
6	morphologically	morphologically	RB	RB	_	5	advmod	_	_
7	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	age	age	NN	NN	_	3	compound	_	_
3	dependence	dependence	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	morphologic	morphologic	JJ	JJ	_	7	amod	_	_
6	risk	risk	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	3	nmod	_	_
8	appears	appear	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	explain	explain	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	15	det	_	_
12	high	high	JJ	JJ	_	15	amod	_	_
13	local	local	JJ	JJ	_	15	amod	_	_
14	failure	failure	NN	NN	_	15	compound	_	_
15	rate	rate	NN	NN	_	10	dobj	_	_
16	seen	see	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	18	case	_	_
18	patients	patient	NNS	NNS	_	16	nmod	_	_
19	younger	younger	JJR	JJR	_	18	amod	_	_
20	than	than	IN	IN	_	21	case	_	_
21	40	40	CD	CD	_	19	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	aldosterone	aldosterone	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	intralymphocytic	intralymphocytic	JJ	JJ	_	6	amod	_	_
6	sodium	sodium	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	potassium	potassium	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	essential	essential	JJ	JJ	_	13	amod	_	_
13	hypertension	hypertension	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	binding	binding	NN	NN	_	31	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	aldosterone	aldosterone	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	mineralocorticoid	mineralocorticoid	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	3	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HML	hml	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	effects	effect	NNS	NNS	_	3	conj	_	_
19	on	on	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	dep	_	_
21	intracellular	intracellular	JJ	JJ	_	22	amod	_	_
22	sodium	sodium	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	potassium	potassium	NN	NN	_	22	conj	_	_
25	concentrations	concentration	NNS	NNS	_	22	dep	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HML	hml	NNS	NNS	_	22	nmod	_	_
28	have	have	VBP	VBP	_	31	aux	_	_
29	already	already	RB	RB	_	31	xcomp	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	described	describe	VBN	VBN	_	0	root	_	_
32	.	.	.	.	_	31	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	paper	paper	NN	NN	_	12	nmod	_	_
5	this	this	DT	DT	_	10	det	_	_
6	easily	easily	RB	RB	_	7	advmod	_	_
7	accessible	accessible	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	model	model	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	investigated	investigate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	13	13	CD	CD	_	15	nummod	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	essential	essential	JJ	JJ	_	18	amod	_	_
18	hypertension	hypertension	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	only	only	RB	RB	_	3	advmod	_	_
3	four	four	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	11	nmod	_	_
5	sodium	sodium	NN	NN	_	11	nsubj	_	_
6	in	in	RP	RP	_	7	dep	_	_
7	HML	hml	NNS	NNS	_	5	nmod	_	_
8	without	without	IN	IN	_	9	case	_	_
9	incubation	incubation	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	aux	_	_
11	elevated	elevated	JJ	JJ	_	0	root	_	_
12	compared	compare	VBN	VBN	_	15	case	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	range	range	NN	NN	_	11	advcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	persons	person	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
5	sodium	sodium	NN	NN	_	2	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	potassium	potassium	NN	NN	_	5	conj	_	_
8	occurred	occur	VBD	VBD	_	0	root	_	_
9	during	during	IN	IN	_	10	case	_	_
10	incubation	incubation	NN	NN	_	8	nmod	_	_
11	without	without	IN	IN	_	12	case	_	_
12	aldosterone	aldosterone	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	P	p	NN	NN	_	10	dep	_	_
15	less	less	JJR	JJR	_	14	amod	_	_
16	than	than	IN	IN	_	17	case	_	_
17	0.02	0.02	CD	CD	_	15	nmod	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	1.4	1.4	CD	CD	_	5	compound	_	_
5	nM	nm	NN	NN	_	6	amod	_	_
6	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	prevent	prevent	VB	VB	_	0	root	_	_
10	this	this	DT	DT	_	11	det	_	_
11	loss	loss	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	electrolytes	electrolyte	NNS	NNS	_	11	nmod	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	observed	observe	VBN	VBN	_	9	advcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	persons	person	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Plasma	plasma	NN	NN	_	2	compound	_	_
2	renin	renin	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	aldosterone	aldosterone	NN	NN	_	3	conj	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	correlated	correlate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	electrolyte	electrolyte	NN	NN	_	12	compound	_	_
12	response	response	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	were	be	VBD	VBD	_	18	cop	_	_
15	within	within	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	limits	limit	NNS	NNS	_	8	conj	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	mineralocorticoid	mineralocorticoid	NN	NN	_	5	compound	_	_
5	receptors/cell	receptors/cell	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	within	within	IN	IN	_	0	root	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	close	close	JJ	JJ	_	7	conj	_	_
10	to	to	TO	TO	_	9	nmod	_	_
11	the	the	DT	DT	_	13	det	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	range	range	NN	NN	_	7	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	n	n	NN	NN	_	7	dep	_	_
16	=	=	JJ	JJ	_	15	amod	_	_
17	9	9	CD	CD	_	16	dep	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	independence	independence	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
5	electrolytes	electrolyte	NNS	NNS	_	2	nmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
8	despite	despite	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	number	number	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	mineralocorticoid	mineralocorticoid	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	11	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	reflect	reflect	VB	VB	_	0	root	_	_
17	an	a	DT	DT	_	18	det	_	_
18	impairment	impairment	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	mineralocorticoid	mineralocorticoid	NN	NN	_	23	compound	_	_
22	effector	effector	NN	NN	_	23	compound	_	_
23	mechanism	mechanism	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	HML	hml	NNS	NNS	_	16	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	patients	patient	NNS	NNS	_	26	nmod	_	_
29	with	with	IN	IN	_	31	case	_	_
30	essential	essential	JJ	JJ	_	31	amod	_	_
31	hypertension	hypertension	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	Megakaryocytic	megakaryocytic	JJ	JJ	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	erythrocytic	erythrocytic	JJ	JJ	_	1	conj	_	_
4	lineages	lineage	NNS	NNS	_	1	dep	_	_
5	share	share	VBP	VBP	_	0	root	_	_
6	specific	specific	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Erythroid-specific	erythroid-specific	JJ	JJ	_	2	amod	_	_
2	genes	gene	NNS	NNS	_	3	nsubj	_	_
3	contain	contain	VBP	VBP	_	0	root	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	NF-E1	nf-e1	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	called	call	VBN	VBN	_	7	dep	_	_
11	GF-1	gf-1	NN	NN	_	10	xcomp	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Eryf-1	eryf-1	NN	NN	_	11	conj	_	_
14	;	;	:	:	_	10	punct	_	_
15	refs	ref	NNS	NNS	_	10	dobj	_	_
16	1-3	1-3	CD	CD	_	15	nummod	_	_
17	respectively	respectively	RB	RB	_	15	advmod	_	_
18	)	)	-RRB-	-RRB-	_	10	punct	_	_
19	,	,	,	,	_	7	punct	_	_
20	the	the	DT	DT	_	23	det	_	_
21	principal	principal	JJ	JJ	_	23	amod	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	7	appos	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	erythrocytic	erythrocytic	JJ	JJ	_	27	amod	_	_
27	lineage	lineage	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	NF-E1	nf-e1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	seems	seem	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	aux	_	_
6	restricted	restricted	JJ	JJ	_	3	xcomp	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	erythrocytic	erythrocytic	JJ	JJ	_	10	amod	_	_
10	lineage	lineage	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	closely	closely	RB	RB	_	3	advmod	_	_
3	related	related	JJ	JJ	_	11	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	if	if	IN	IN	_	6	dep	_	_
6	not	not	RB	RB	_	7	cc	_	_
7	identical	identical	JJ	JJ	_	3	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	protein	protein	NN	NN	_	3	dep	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	18	case	_	_
13	both	both	CC	CC	_	18	cc:preconj	_	_
14	a	a	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	megakaryocytic	megakaryocytic	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	11	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	purified	purify	VBN	VBN	_	22	amod	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	megakaryocytes	megakaryocyte	NNS	NNS	_	18	conj	_	_
23	;	;	:	:	_	11	punct	_	_
24	it	it	PRP	PRP	_	11	parataxis	_	_
25	binds	bind	VBZ	VBZ	_	24	dep	_	_
26	to	to	TO	TO	_	28	case	_	_
27	promoter	promoter	NN	NN	_	28	compound	_	_
28	regions	region	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	two	two	CD	CD	_	32	nummod	_	_
31	megakaryocytic-specific	megakaryocytic-specific	JJ	JJ	_	32	amod	_	_
32	genes	gene	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	sites	site	NNS	NNS	_	12	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	partial	partial	JJ	JJ	_	7	amod	_	_
6	proteolysis	proteolysis	NN	NN	_	7	compound	_	_
7	profile	profile	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	protein	protein	NN	NN	_	3	nmod	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
13	from	from	IN	IN	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	14	nmod	_	_
19	;	;	:	:	_	12	punct	_	_
20	also	also	RB	RB	_	28	advmod	_	_
21	,	,	,	,	_	28	punct	_	_
22	NF-E1	nf-e1	NN	NN	_	24	compound	_	_
23	messenger	messenger	NN	NN	_	24	compound	_	_
24	RNA	rna	NN	NN	_	28	nsubj	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	the	the	DT	DT	_	28	det	_	_
27	same	same	JJ	JJ	_	28	amod	_	_
28	size	size	NN	NN	_	12	parataxis	_	_
29	in	in	IN	IN	_	32	case	_	_
30	both	both	CC	CC	_	32	cc:preconj	_	_
31	the	the	DT	DT	_	32	dep	_	_
32	megakaryocytic	megakaryocytic	JJ	JJ	_	28	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	erythroid	erythroid	JJ	JJ	_	32	conj	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	32	dep	_	_
37	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	point	point	NN	NN	_	4	compound	_	_
4	mutations	mutation	NNS	NNS	_	10	nsubj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	abolish	abolish	VBP	VBP	_	4	acl:relcl	_	_
7	binding	binding	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-E1	nf-e1	NN	NN	_	7	nmod	_	_
10	result	result	VBP	VBP	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	70	70	CD	CD	_	14	compound	_	_
14	%	%	NN	NN	_	15	amod	_	_
15	decrease	decrease	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	megakaryocytic-specific	megakaryocytic-specific	JJ	JJ	_	23	amod	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	find	find	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	NF-E2	nf-e2	NN	NN	_	16	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	another	another	DT	DT	_	9	det	_	_
8	trans-acting	trans-acting	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	appos	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	erythrocytic	erythrocytic	JJ	JJ	_	13	amod	_	_
13	lineage	lineage	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	present	present	JJ	JJ	_	3	ccomp	_	_
17	in	in	IN	IN	_	18	case	_	_
18	megakaryocytes	megakaryocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	9	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	det	_	_
5	lineages	lineage	NNS	NNS	_	2	nmod	_	_
6	might	might	MD	MD	_	9	aux	_	_
7	then	then	RB	RB	_	9	advmod	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	part	part	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	same	same	JJ	JJ	_	17	amod	_	_
15	specific	specific	JJ	JJ	_	14	dep	_	_
16	trans-acting	trans-acting	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	strengthen	strengthen	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	idea	idea	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	close	close	JJ	JJ	_	9	amod	_	_
9	association	association	NN	NN	_	5	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	erythrocytic	erythrocytic	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	megakaryocytic	megakaryocytic	JJ	JJ	_	12	conj	_	_
16	lineages	lineage	NNS	NNS	_	12	dep	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	could	could	MD	MD	_	20	aux	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	explain	explain	VB	VB	_	3	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	markers	marker	NNS	NNS	_	22	nmod	_	_
25	specific	specific	JJ	JJ	_	24	amod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	dep	_	_
28	erythrocytic	erythrocytic	JJ	JJ	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	megakaryocytic	megakaryocytic	JJ	JJ	_	28	conj	_	_
31	lineages	lineage	NNS	NNS	_	28	dep	_	_
32	in	in	IN	IN	_	34	case	_	_
33	most	most	JJS	JJS	_	34	amod	_	_
34	erythroblastic	erythroblastic	JJ	JJ	_	28	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	megakaryoblastic	megakaryoblastic	JJ	JJ	_	34	conj	_	_
37	permanent	permanent	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	lines	line	NNS	NNS	_	34	dep	_	_
40	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	member	member	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	leucine	leucine	NN	NN	_	8	compound	_	_
7	zipper	zipper	NN	NN	_	8	compound	_	_
8	class	class	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	proteins	protein	NNS	NNS	_	8	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
13	to	to	TO	TO	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	HLA	hla	NN	NN	_	18	compound	_	_
16	DR	dr	NN	NN	_	18	compound	_	_
17	alpha	alpha	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	mutants	mutant	NNS	NNS	_	11	nsubj	_	_
3	derived	derive	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	9	case	_	_
5	transformed	transform	VBN	VBN	_	9	amod	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	3	nmod	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	defective	defective	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	expressing	express	VBG	VBG	_	11	advcl	_	_
14	major	major	JJ	JJ	_	22	amod	_	_
15	histocompatibility	histocompatibility	NN	NN	_	22	compound	_	_
16	complex	complex	NN	NN	_	22	compound	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	MHC	mhc	NN	NN	_	22	compound	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	genes	gene	NNS	NNS	_	13	dobj	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	failure	failure	NN	NN	_	18	nsubjpass	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	express	express	VB	VB	_	2	acl	_	_
5	a	a	DT	DT	_	8	det	_	_
6	class	class	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	gene	gene	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	15	case	_	_
10	at	at	IN	IN	_	11	case	_	_
11	least	least	JJS	JJS	_	12	nmod:npmod	_	_
12	one	one	CD	CD	_	15	nummod	_	_
13	such	such	JJ	JJ	_	15	amod	_	_
14	mutant	mutant	JJ	JJ	_	15	amod	_	_
15	line	line	NN	NN	_	4	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	mapped	map	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	25	case	_	_
20	the	the	DT	DT	_	25	det	_	_
21	MHC	mhc	NN	NN	_	25	compound	_	_
22	class	class	NN	NN	_	25	compound	_	_
23	II	ii	CD	CD	_	25	nummod	_	_
24	X	x	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	a	a	DT	DT	_	30	det	_	_
28	conserved	conserve	VBN	VBN	_	30	amod	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	element	element	NN	NN	_	25	appos	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	promoter	promoter	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	18	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	complementary	complementary	JJ	JJ	_	3	amod	_	_
3	DNA	dna	NN	NN	_	34	nsubjpass	_	_
4	encoding	encode	VBG	VBG	_	3	acl	_	_
5	a	a	DT	DT	_	7	det	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	X	x	NN	NN	_	13	compound	_	_
11	box	box	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	7	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	hXBP-1	hxbp-1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	13	punct	_	_
17	whose	whose	WP$	WP$	_	18	nmod:poss	_	_
18	target	target	NN	NN	_	25	nsubj	_	_
19	is	be	VBZ	VBZ	_	25	cop	_	_
20	the	the	DT	DT	_	25	det	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	DR	dr	NN	NN	_	25	compound	_	_
23	alpha	alpha	NN	NN	_	25	compound	_	_
24	X	x	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	7	acl:relcl	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	30	det	_	_
28	3'	3'	JJ	JJ	_	30	amod	_	_
29	flanking	flanking	JJ	JJ	_	30	amod	_	_
30	region	region	NN	NN	_	25	conj	_	_
31	has	have	VBZ	VBZ	_	34	aux	_	_
32	now	now	RB	RB	_	34	advmod	_	_
33	been	be	VBN	VBN	_	34	auxpass	_	_
34	cloned	clone	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	complementary	complementary	JJ	JJ	_	3	amod	_	_
3	DNA	dna	NN	NN	_	4	nsubj	_	_
4	encoded	encode	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	4	dobj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	structural	structural	JJ	JJ	_	9	amod	_	_
9	similarities	similarity	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	c-jun	c-jun	NN	NN	_	14	compound	_	_
13	proto-oncogene	proto-oncogene	NN	NN	_	14	compound	_	_
14	product	product	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	target	target	NN	NN	_	19	compound	_	_
19	sequence	sequence	NN	NN	_	22	nsubj	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	closely	closely	RB	RB	_	22	advmod	_	_
22	related	related	JJ	JJ	_	4	conj	_	_
23	to	to	TO	TO	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	palindromic	palindromic	JJ	JJ	_	27	amod	_	_
26	target	target	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	c-jun	c-jun	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Mutation	mutation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	hXBP-1	hxbp-1	NN	NN	_	7	compound	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	target	target	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	decreased	decrease	VBD	VBD	_	0	root	_	_
9	DR	dr	NN	NN	_	11	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	dobj	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	8	advmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	hXBP-1	hxbp-1	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	8	nsubj	_	_
8	acts	act	VBZ	VBZ	_	3	ccomp	_	_
9	as	as	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	novel	novel	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	interacts	interact	VBZ	VBZ	_	5	acl:relcl	_	_
8	with	with	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	immunoglobulin	immunoglobulin	NN	NN	_	12	compound	_	_
11	heavy-chain	heavy-chain	JJ	JJ	_	12	amod	_	_
12	promoter	promoter	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	stimulates	stimulate	VBZ	VBZ	_	7	conj	_	_
15	transcription	transcription	NN	NN	_	14	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	conjunction	conjunction	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
21	cell-specific	cell-specific	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	17	nmod	_	_
23	OTF2	otf2	NN	NN	_	22	dep	_	_
24	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	tissue-specific	tissue-specific	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	MOPC	mopc	NN	NN	_	10	compound	_	_
7	141	141	CD	CD	_	10	nummod	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	10	compound	_	_
9	heavy-chain	heavy-chain	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	3	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	studied	study	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	mark	_	_
14	using	use	VBG	VBG	_	17	amod	_	_
15	in	in	FW	FW	_	17	amod	_	_
16	vitro	vitro	FW	FW	_	15	dep	_	_
17	transcription	transcription	NN	NN	_	12	advcl	_	_
18	.	.	.	.	_	12	punct	_	_

1	B-cell-specific	b-cell-specific	JJ	JJ	_	2	amod	_	_
2	transcription	transcription	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	gene	gene	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	dependent	dependent	JJ	JJ	_	0	root	_	_
8	on	on	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	octamer	octamer	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	12	compound	_	_
12	5'-ATGCAAAG-3'	5'-atgcaaag-3'	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	located	located	JJ	JJ	_	12	amod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	upstream	upstream	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	promoters	promoter	NNS	NNS	_	18	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	all	all	DT	DT	_	29	det	_	_
28	other	other	JJ	JJ	_	29	amod	_	_
29	immunoglobulin	immunoglobulin	NN	NN	_	25	nmod	_	_
30	heavy-	heavy-	JJ	JJ	_	29	dep	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	light-chain	light-chain	JJ	JJ	_	29	conj	_	_
33	genes	gene	NNS	NNS	_	29	dep	_	_
34	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	22	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	purified	purify	VBN	VBN	_	7	amod	_	_
5	octamer	octamer	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	1	1	CD	CD	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	2	2	CD	CD	_	7	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	OTF1	otf1	NN	NN	_	7	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	OTF2	otf2	NN	NN	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	with	with	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	MOPC	mopc	NN	NN	_	20	compound	_	_
19	141	141	CD	CD	_	20	nummod	_	_
20	promoter	promoter	NN	NN	_	2	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	studied	study	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	using	use	VBG	VBG	_	22	advcl	_	_
25	electrophoretic	electrophoretic	JJ	JJ	_	28	amod	_	_
26	mobility	mobility	NN	NN	_	28	compound	_	_
27	shift	shift	NN	NN	_	28	compound	_	_
28	assays	assay	NNS	NNS	_	24	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	DNase	dnase	NN	NN	_	32	compound	_	_
31	I	i	CD	CD	_	30	nummod	_	_
32	footprinting	footprinting	NN	NN	_	28	conj	_	_
33	.	.	.	.	_	22	punct	_	_

1	Purified	purify	VBN	VBN	_	2	amod	_	_
2	OTF1	otf1	NN	NN	_	13	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	HeLa	hela	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	OTF1	otf1	NN	NN	_	2	conj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	OTF2	otf2	NN	NN	_	7	conj	_	_
10	from	from	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	bound	bind	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	identical	identical	JJ	JJ	_	16	amod	_	_
16	sequences	sequence	NNS	NNS	_	13	nmod	_	_
17	within	within	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	heavy-chain	heavy-chain	JJ	JJ	_	20	amod	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	OTF	otf	NN	NN	_	3	compound	_	_
3	interactions	interaction	NNS	NNS	_	6	nsubj	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	observed	observe	VBD	VBD	_	3	acl:relcl	_	_
6	extended	extend	VBD	VBD	_	0	root	_	_
7	over	over	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	heptamer	heptamer	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	11	compound	_	_
11	5'-CTCAGGA-3'	5'-ctcagga-3'	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	seems	seem	VBZ	VBZ	_	6	conj	_	_
16	likely	likely	RB	RB	_	15	xcomp	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	binding	binding	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	purified	purify	VBN	VBN	_	23	amod	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	involves	involve	VBZ	VBZ	_	16	ccomp	_	_
25	cooperation	cooperation	NN	NN	_	24	dobj	_	_
26	between	between	IN	IN	_	27	case	_	_
27	octamer	octamer	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	heptamer	heptamer	NN	NN	_	27	conj	_	_
30	sites	site	NNS	NNS	_	27	dep	_	_
31	in	in	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	promoter	promoter	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	elements	element	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	second	second	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	N	n	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	12	appos	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	5'-GGAACCTCCCCC-3'	5'-ggaacctccccc-3'	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	N	n	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	6	nsubj	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	independently	independently	RB	RB	_	6	advmod	_	_
6	mediate	mediate	VB	VB	_	0	root	_	_
7	low	low	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	B-cell	b-cell	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HeLa-cell	hela-cell	JJ	JJ	_	13	conj	_	_
16	extracts	extract	NNS	NNS	_	13	dep	_	_
17	,	,	,	,	_	6	punct	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	,	,	,	,	_	6	punct	_	_
20	in	in	IN	IN	_	21	case	_	_
21	conjunction	conjunction	NN	NN	_	29	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	octamer	octamer	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	29	punct	_	_
27	it	it	PRP	PRP	_	29	nsubj	_	_
28	can	can	MD	MD	_	29	aux	_	_
29	promote	promote	VB	VB	_	6	conj	_	_
30	high	high	JJ	JJ	_	31	amod	_	_
31	levels	level	NNS	NNS	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	transcription	transcription	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	B-cell	b-cell	NN	NN	_	36	compound	_	_
36	extracts	extract	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	N	n	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	4	nsubj	_	_
4	bound	bind	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	NTF	ntf	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	9	punct	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	ubiquitous	ubiquitous	JJ	JJ	_	9	acl:relcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	cell-type	cell-type	JJ	JJ	_	16	amod	_	_
16	distribution	distribution	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	NTF	ntf	NN	NN	_	21	nsubj	_	_
20	was	be	VBD	VBD	_	21	cop	_	_
21	distinct	distinct	JJ	JJ	_	4	conj	_	_
22	from	from	IN	IN	_	23	case	_	_
23	any	any	DT	DT	_	21	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	previously	previously	RB	RB	_	28	advmod	_	_
27	described	describe	VBN	VBN	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	23	nmod	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	bind	bind	VBP	VBP	_	28	acl:relcl	_	_
31	to	to	TO	TO	_	33	case	_	_
32	similar	similar	JJ	JJ	_	33	amod	_	_
33	sequences	sequence	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	7	advcl	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	propose	propose	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	29	mark	_	_
9	NTF	ntf	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	OTF2	otf2	NN	NN	_	9	conj	_	_
12	interactions	interaction	NNS	NNS	_	29	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	19	punct	_	_
14	both	both	CC	CC	_	19	cc:preconj	_	_
15	with	with	IN	IN	_	19	case	_	_
16	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
17	cognate	cognate	JJ	JJ	_	19	amod	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	12	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	possibly	possibly	RB	RB	_	25	advmod	_	_
22	at	at	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	protein-protein	protein-protein	JJ	JJ	_	25	amod	_	_
25	level	level	NN	NN	_	19	conj	_	_
26	)	)	-RRB-	-RRB-	_	19	punct	_	_
27	may	may	MD	MD	_	29	aux	_	_
28	be	be	VB	VB	_	29	cop	_	_
29	critical	critical	JJ	JJ	_	7	ccomp	_	_
30	to	to	TO	TO	_	32	case	_	_
31	B-cell-specific	b-cell-specific	JJ	JJ	_	32	amod	_	_
32	expression	expression	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	that	that	IN	IN	_	37	mark	_	_
35	these	these	DT	DT	_	36	det	_	_
36	interactions	interaction	NNS	NNS	_	37	nsubj	_	_
37	provide	provide	VBP	VBP	_	29	conj	_	_
38	additional	additional	JJ	JJ	_	39	amod	_	_
39	pathways	pathway	NNS	NNS	_	37	dobj	_	_
40	for	for	IN	IN	_	41	mark	_	_
41	regulating	regulate	VBG	VBG	_	39	acl	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	expression	expression	NN	NN	_	41	dobj	_	_
44	.	.	.	.	_	7	punct	_	_

1	1,25(OH)2D2	1,25(oh)2d2	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	alveolar	alveolar	JJ	JJ	_	8	amod	_	_
8	macrophages	macrophage	NNS	NNS	_	5	conj	_	_
9	recovered	recover	VBN	VBN	_	5	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	lavage	lavage	NN	NN	_	9	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	normocalcemic	normocalcemic	JJ	JJ	_	14	amod	_	_
14	patients	patient	NNS	NNS	_	11	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	tuberculosis	tuberculosis	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	compare	compare	VB	VB	_	0	root	_	_
3	extra-renal	extra-renal	JJ	JJ	_	5	amod	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	types	type	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	granulomatous	granulomatous	JJ	JJ	_	11	amod	_	_
11	disease	disease	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	identify	identify	VB	VB	_	2	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	15	dobj	_	_
19	responsible	responsible	JJ	JJ	_	18	amod	_	_
20	,	,	,	,	_	2	punct	_	_
21	we	we	PRP	PRP	_	23	nsubj	_	_
22	have	have	VBP	VBP	_	23	aux	_	_
23	evaluated	evaluate	VBN	VBN	_	2	parataxis	_	_
24	the	the	DT	DT	_	25	det	_	_
25	conversion	conversion	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	25(OH)D3	25(oh)d3	NN	NN	_	25	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	27	nmod	_	_
30	by	by	IN	IN	_	32	case	_	_
31	uncultured	uncultured	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	23	nmod	_	_
33	recovered	recover	VBN	VBN	_	32	acl	_	_
34	by	by	IN	IN	_	36	case	_	_
35	bronchoalveolar	bronchoalveolar	JJ	JJ	_	36	amod	_	_
36	lavage	lavage	NN	NN	_	33	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	blood	blood	NN	NN	_	40	compound	_	_
39	mononuclear	mononuclear	JJ	JJ	_	40	amod	_	_
40	cells	cell	NNS	NNS	_	36	conj	_	_
41	from	from	IN	IN	_	43	case	_	_
42	normocalcemic	normocalcemic	JJ	JJ	_	43	amod	_	_
43	patients	patient	NNS	NNS	_	36	nmod	_	_
44	with	with	IN	IN	_	45	case	_	_
45	sarcoidosis	sarcoidosis	NN	NN	_	43	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	tuberculosis	tuberculosis	NN	NN	_	45	conj	_	_
48	.	.	.	.	_	2	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	produced	produce	VBN	VBN	_	0	root	_	_
4	both	both	CC	CC	_	3	dep	_	_
5	by	by	IN	IN	_	7	case	_	_
6	lavage	lavage	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	conj	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	12/12	12/12	CD	CD	_	11	nummod	_	_
10	tuberculosis	tuberculosis	NN	NN	_	11	compound	_	_
11	patients	patient	NNS	NNS	_	7	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	2/6	2/6	CD	CD	_	11	nummod	_	_
14	sarcoidosis	sarcoidosis	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	11	dep	_	_
16	)	)	-RRB-	-RRB-	_	11	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	blood	blood	NN	NN	_	20	compound	_	_
19	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	7	conj	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	3/5	3/5	CD	CD	_	24	nummod	_	_
23	tuberculosis	tuberculosis	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	20	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	0/3	0/3	CD	CD	_	28	nummod	_	_
27	sarcoidosis	sarcoidosis	NN	NN	_	28	compound	_	_
28	patients	patient	NNS	NNS	_	24	appos	_	_
29	)	)	-RRB-	-RRB-	_	24	punct	_	_
30	from	from	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	7	nmod	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	31	cc	_	_
34	controls	control	NNS	NNS	_	31	conj	_	_
35	,	,	,	,	_	3	punct	_	_
36	but	but	CC	CC	_	3	cc	_	_
37	significantly	significantly	RB	RB	_	38	advmod	_	_
38	greater	greater	JJR	JJR	_	39	amod	_	_
39	amounts	amount	NNS	NNS	_	41	nsubjpass	_	_
40	were	be	VBD	VBD	_	41	auxpass	_	_
41	produced	produce	VBN	VBN	_	3	conj	_	_
42	by	by	IN	IN	_	44	case	_	_
43	lavage	lavage	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	41	nmod	_	_
45	from	from	IN	IN	_	47	case	_	_
46	tuberculosis	tuberculosis	NN	NN	_	47	compound	_	_
47	patients	patient	NNS	NNS	_	44	nmod	_	_
48	than	than	IN	IN	_	49	case	_	_
49	those	those	DT	DT	_	41	nmod	_	_
50	of	of	IN	IN	_	52	case	_	_
51	sarcoidosis	sarcoidosis	NN	NN	_	52	compound	_	_
52	patients	patient	NNS	NNS	_	49	nmod	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	P	p	NN	NN	_	52	dep	_	_
55	less	less	JJR	JJR	_	54	amod	_	_
56	than	than	IN	IN	_	57	case	_	_
57	0.001	0.001	CD	CD	_	55	nmod	_	_
58	)	)	-RRB-	-RRB-	_	54	punct	_	_
59	.	.	.	.	_	3	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	9	nsubj	_	_
3	by	by	IN	IN	_	5	case	_	_
4	lavage	lavage	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	tuberculosis	tuberculosis	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	correlated	correlate	VBD	VBD	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	CD8+	cd8+	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
17	present	present	JJ	JJ	_	16	amod	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	16	cc	_	_
20	other	other	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	types	type	NNS	NNS	_	16	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	3	nsubj	_	_
3	appeared	appear	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	8	mark	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	source	source	NN	NN	_	3	xcomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	since	since	IN	IN	_	22	mark	_	_
14	purified	purify	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	22	nsubj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	all	all	DT	DT	_	19	det	_	_
19	patients	patient	NNS	NNS	_	16	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	tuberculosis	tuberculosis	NN	NN	_	19	nmod	_	_
22	produced	produce	VBD	VBD	_	3	advcl	_	_
23	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	22	dobj	_	_
24	,	,	,	,	_	22	punct	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	31	nsubj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	correlated	correlate	VBD	VBD	_	22	conj	_	_
32	closely	closely	RB	RB	_	31	advmod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	that	that	DT	DT	_	31	nmod	_	_
35	produced	produce	VBN	VBN	_	34	acl	_	_
36	by	by	IN	IN	_	39	case	_	_
37	unseparated	unseparated	JJ	JJ	_	39	amod	_	_
38	lavage	lavage	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	4	mark	_	_
2	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	improve	improve	VB	VB	_	15	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	capacity	capacity	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	macrophages	macrophage	NNS	NNS	_	6	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	kill	kill	VB	VB	_	6	acl	_	_
11	mycobacteria	mycobacterium	NNS	NNS	_	10	dobj	_	_
12	,	,	,	,	_	15	punct	_	_
13	our	we	PRP$	PRP$	_	14	nmod:poss	_	_
14	results	result	NNS	NNS	_	15	nsubj	_	_
15	support	support	VBP	VBP	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	conclusion	conclusion	NN	NN	_	15	dobj	_	_
18	that	that	IN	IN	_	34	mark	_	_
19	macrophage-lymphocyte	macrophage-lymphocyte	JJ	JJ	_	20	amod	_	_
20	interactions	interaction	NNS	NNS	_	34	nsubj	_	_
21	,	,	,	,	_	20	punct	_	_
22	mediated	mediate	VBN	VBN	_	20	acl	_	_
23	at	at	IN	IN	_	26	advmod	_	_
24	least	least	JJS	JJS	_	23	mwe	_	_
25	in	in	IN	IN	_	26	case	_	_
26	part	part	NN	NN	_	22	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	22	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	may	may	MD	MD	_	34	aux	_	_
31	be	be	VB	VB	_	34	cop	_	_
32	an	a	DT	DT	_	34	det	_	_
33	important	important	JJ	JJ	_	34	amod	_	_
34	component	component	NN	NN	_	17	ccomp	_	_
35	of	of	IN	IN	_	40	case	_	_
36	a	a	DT	DT	_	40	det	_	_
37	successful	successful	JJ	JJ	_	40	amod	_	_
38	antituberculous	antituberculous	JJ	JJ	_	40	amod	_	_
39	immune	immune	JJ	JJ	_	40	amod	_	_
40	response	response	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	15	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	1	1	CD	CD	_	7	nummod	_	_
4	alpha	alpha	NN	NN	_	7	compound	_	_
5	,	,	,	,	_	7	punct	_	_
6	25-dihydroxyvitamin	25-dihydroxyvitamin	NN	NN	_	7	dep	_	_
7	D3	d3	NN	NN	_	1	nmod	_	_
8	on	on	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	human	human	JJ	JJ	_	15	amod	_	_
11	chronic	chronic	JJ	JJ	_	15	amod	_	_
12	myelogenous	myelogenous	JJ	JJ	_	15	amod	_	_
13	leukemia	leukemia	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	1	nmod	_	_
16	RWLeu-4	rwleu-4	NN	NN	_	15	dep	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	34	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	1	1	CD	CD	_	8	nummod	_	_
5	alpha	alpha	NN	NN	_	8	compound	_	_
6	,	,	,	,	_	8	punct	_	_
7	25-dihydroxyvitamin	25-dihydroxyvitamin	NN	NN	_	8	dep	_	_
8	D3	d3	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VD3	vd3	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	on	on	IN	IN	_	13	case	_	_
13	proliferation	proliferation	NN	NN	_	2	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	differentiation	differentiation	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	macromolecular	macromolecular	JJ	JJ	_	19	amod	_	_
19	synthesis	synthesis	NN	NN	_	13	conj	_	_
20	in	in	IN	IN	_	29	case	_	_
21	the	the	DT	DT	_	29	det	_	_
22	new	new	JJ	JJ	_	29	amod	_	_
23	Philadelphia	philadelphia	NN	NN	_	29	compound	_	_
24	chromosome-positive	chromosome-positive	JJ	JJ	_	29	amod	_	_
25	chronic	chronic	JJ	JJ	_	29	amod	_	_
26	myelogenous	myelogenous	JJ	JJ	_	29	amod	_	_
27	leukemia	leukemia	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	13	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	RWLeu-4	rwleu-4	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	2	punct	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	investigated	investigate	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	Binding	binding	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	-LSB-3H-RSB-VD3	-lsb-3h-rsb-vd3	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	saturable	saturable	JJ	JJ	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	with	with	IN	IN	_	10	case	_	_
8	approximately	approximately	RB	RB	_	9	advmod	_	_
9	2000-3000	2000-3000	CD	CD	_	10	nummod	_	_
10	sites/cell	sites/cell	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	half-maximal	half-maximal	JJ	JJ	_	14	amod	_	_
14	binding	binding	NN	NN	_	15	nsubj	_	_
15	occurring	occur	VBG	VBG	_	5	conj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	0.21-0.33	0.21-0.33	CD	CD	_	18	nummod	_	_
18	nM	nm	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Treatment	treatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	RWLeu-4	rwleu-4	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	VD3	vd3	NN	NN	_	1	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	24R-hydroxylase	24r-hydroxylase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	marker	marker	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	vitamin	vitamin	NN	NN	_	16	compound	_	_
15	D3	d3	NN	NN	_	16	compound	_	_
16	responsiveness	responsiveness	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	many	many	JJ	JJ	_	19	amod	_	_
19	tissues	tissue	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Exposure	exposure	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	RWLeu-4	rwleu-4	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	VD3	vd3	NN	NN	_	1	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	proliferation	proliferation	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	9	conj	_	_
13	with	with	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	50	50	CD	CD	_	16	compound	_	_
16	%	%	NN	NN	_	18	amod	_	_
17	effective	effective	JJ	JJ	_	18	amod	_	_
18	dose	dose	NN	NN	_	8	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	3.5-10	3.5-10	CD	CD	_	21	nummod	_	_
21	nM	nm	NN	NN	_	18	nmod	_	_
22	within	within	IN	IN	_	24	case	_	_
23	72	72	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	8	nmod	_	_
25	;	;	:	:	_	8	punct	_	_
26	in	in	IN	IN	_	27	case	_	_
27	addition	addition	NN	NN	_	34	nmod	_	_
28	,	,	,	,	_	34	punct	_	_
29	protein	protein	NN	NN	_	34	nsubjpass	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	RNA	rna	NN	NN	_	32	compound	_	_
32	synthesis	synthesis	NN	NN	_	29	conj	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	inhibited	inhibit	VBN	VBN	_	8	parataxis	_	_
35	by	by	IN	IN	_	37	case	_	_
36	VD3	vd3	NN	NN	_	37	compound	_	_
37	treatment	treatment	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	Exposure	exposure	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	RWLeu-4	rwleu-4	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	5	5	CD	CD	_	7	compound	_	_
7	nM	nm	NN	NN	_	8	amod	_	_
8	VD3	vd3	NN	NN	_	1	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	72	72	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	1	nmod	_	_
12	caused	cause	VBD	VBD	_	0	root	_	_
13	50	50	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	differentiate	differentiate	VB	VB	_	12	xcomp	_	_
20	into	into	IN	IN	_	23	case	_	_
21	macrophage/monocyte	macrophage/monocyte	JJ	JJ	_	23	amod	_	_
22	type	type	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	judged	judge	VBN	VBN	_	19	advcl	_	_
26	by	by	IN	IN	_	29	case	_	_
27	nitroblue	nitroblue	JJ	JJ	_	29	amod	_	_
28	tetrazolium	tetrazolium	NN	NN	_	29	compound	_	_
29	staining	staining	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	adherence	adherence	NN	NN	_	29	conj	_	_
32	to	to	TO	TO	_	33	case	_	_
33	plastic	plastic	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	12	punct	_	_

1	Progressive	progressive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	surface	surface	NN	NN	_	7	compound	_	_
6	maturation-specific	maturation-specific	JJ	JJ	_	7	amod	_	_
7	antigens	antigen	NNS	NNS	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	monocyte/macrophage	monocyte/macrophage	JJ	JJ	_	11	amod	_	_
11	lineage	lineage	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	treatment	treatment	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	RWLeu-4	rwleu-4	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	VD3	vd3	NN	NN	_	15	nmod	_	_
21	for	for	IN	IN	_	25	case	_	_
22	24	24	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	72	72	CD	CD	_	25	nummod	_	_
25	h	h	NN	NN	_	13	nmod	_	_
26	at	at	IN	IN	_	27	case	_	_
27	doses	dose	NNS	NNS	_	13	nmod	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	inhibited	inhibit	VBD	VBD	_	27	acl:relcl	_	_
30	cellular	cellular	JJ	JJ	_	31	amod	_	_
31	proliferation	proliferation	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	13	punct	_	_

1	c-myc	c-myc	NN	NN	_	2	compound	_	_
2	RNA	rna	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	constitutively	constitutively	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	2	acl:relcl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	RWLeu-4	rwleu-4	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	after	after	IN	IN	_	15	case	_	_
14	0.5	0.5	CD	CD	_	15	nummod	_	_
15	h	h	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	treatment	treatment	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	50	50	CD	CD	_	20	compound	_	_
20	nM	nm	NN	NN	_	21	amod	_	_
21	VD3	vd3	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	then	then	RB	RB	_	12	advmod	_	_
24	rapidly	rapidly	RB	RB	_	12	advmod	_	_
25	decreased	decrease	VBD	VBD	_	12	dep	_	_
26	to	to	TO	TO	_	29	case	_	_
27	barely	barely	RB	RB	_	28	advmod	_	_
28	detectable	detectable	JJ	JJ	_	29	amod	_	_
29	levels	level	NNS	NNS	_	25	nmod	_	_
30	after	after	IN	IN	_	32	case	_	_
31	4	4	CD	CD	_	32	nummod	_	_
32	h	h	NN	NN	_	25	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	treatment	treatment	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	8	det	_	_
4	in	in	FW	FW	_	8	amod	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	16	nsubjpass	_	_
9	associated	associate	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	p210bcr-abl	p210bcr-abl	NN	NN	_	14	compound	_	_
13	oncogene	oncogene	NN	NN	_	14	compound	_	_
14	product	product	NN	NN	_	9	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	decreased	decrease	VBN	VBN	_	0	root	_	_
17	approximately	approximately	RB	RB	_	18	advmod	_	_
18	50	50	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	16	dobj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	VD3	vd3	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	Because	because	IN	IN	_	4	case	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	22	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	functional	functional	JJ	JJ	_	9	amod	_	_
8	receptor-effector	receptor-effector	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	4	nmod	_	_
10	for	for	IN	IN	_	11	case	_	_
11	VD3	vd3	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	multiple	multiple	JJ	JJ	_	15	amod	_	_
14	biological	biological	JJ	JJ	_	15	amod	_	_
15	responses	response	NNS	NNS	_	11	conj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	hormone	hormone	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	22	nsubj	_	_
22	provide	provide	VBP	VBP	_	0	root	_	_
23	a	a	DT	DT	_	26	det	_	_
24	unique	unique	JJ	JJ	_	26	amod	_	_
25	model	model	NN	NN	_	26	compound	_	_
26	system	system	NN	NN	_	22	dobj	_	_
27	with	with	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	30	nmod	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	probe	probe	VB	VB	_	26	acl:relcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	specific	specific	JJ	JJ	_	33	amod	_	_
33	effects	effect	NNS	NNS	_	30	dobj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	VD3	vd3	NN	NN	_	33	nmod	_	_
36	on	on	IN	IN	_	37	case	_	_
37	cell	cell	NN	NN	_	33	nmod	_	_
38	growth	growth	NN	NN	_	37	dep	_	_
39	and	and	CC	CC	_	37	cc	_	_
40	differentiation	differentiation	NN	NN	_	37	conj	_	_
41	in	in	IN	IN	_	44	case	_	_
42	chronic	chronic	JJ	JJ	_	44	amod	_	_
43	myelogenous	myelogenous	JJ	JJ	_	44	amod	_	_
44	leukemia	leukemia	NN	NN	_	30	nmod	_	_
45	.	.	.	.	_	22	punct	_	_

1	Quantitative	quantitative	JJ	JJ	_	3	amod	_	_
2	immunohistochemical	immunohistochemical	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
6	infiltrates	infiltrate	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	breast	breast	NN	NN	_	9	compound	_	_
9	carcinomas	carcinoma	NNS	NNS	_	3	nmod	_	_
10	--	--	:	:	_	3	punct	_	_
11	correlation	correlation	NN	NN	_	3	dep	_	_
12	with	with	IN	IN	_	14	case	_	_
13	tumour	tumour	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Inflammatory	inflammatory	JJ	JJ	_	2	amod	_	_
2	infiltrates	infiltrate	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	analysed	analyse	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	tissue	tissue	NN	NN	_	7	compound	_	_
7	sections	section	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	76	76	CD	CD	_	11	nummod	_	_
10	breast	breast	NN	NN	_	11	compound	_	_
11	carcinomas	carcinoma	NNS	NNS	_	7	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	counting	count	VBG	VBG	_	4	dep	_	_
14	the	the	DT	DT	_	15	det	_	_
15	percentage	percentage	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	IgA+	iga+	JJ	JJ	_	15	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IgG+	igg+	JJ	JJ	_	19	conj	_	_
22	plasma	plasma	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	dep	_	_
24	,	,	,	,	_	15	punct	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	15	conj	_	_
27	with	with	IN	IN	_	29	case	_	_
28	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
29	subpopulations	subpopulation	NNS	NNS	_	26	nmod	_	_
30	,	,	,	,	_	15	punct	_	_
31	and	and	CC	CC	_	15	cc	_	_
32	natural	natural	JJ	JJ	_	34	amod	_	_
33	killer	killer	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	15	conj	_	_
35	,	,	,	,	_	13	punct	_	_
36	and	and	CC	CC	_	13	cc	_	_
37	by	by	IN	IN	_	38	mark	_	_
38	measuring	measure	VBG	VBG	_	13	conj	_	_
39	postcapillary	postcapillary	JJ	JJ	_	40	amod	_	_
40	venules	venule	NNS	NNS	_	38	dobj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	PCVs	pcv	NNS	NNS	_	40	dep	_	_
43	,	,	,	,	_	42	punct	_	_
44	found	find	VBN	VBN	_	42	acl	_	_
45	in	in	IN	IN	_	47	case	_	_
46	12	12	CD	CD	_	47	nummod	_	_
47	cases	case	NNS	NNS	_	44	nmod	_	_
48	)	)	-RRB-	-RRB-	_	42	punct	_	_
49	within	within	IN	IN	_	51	case	_	_
50	the	the	DT	DT	_	51	det	_	_
51	infiltrates	infiltrate	NNS	NNS	_	40	nmod	_	_
52	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	parameters	parameter	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	correlated	correlate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	grade	grade	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	biochemically	biochemically	RB	RB	_	10	advmod	_	_
10	determined	determine	VBN	VBN	_	13	amod	_	_
11	hormone	hormone	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	status	status	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	known	known	JJ	JJ	_	16	amod	_	_
16	markers	marker	NNS	NNS	_	7	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	tumour	tumour	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	direct	direct	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	extent	extent	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	inflammation	inflammation	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	grade	grade	NN	NN	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	P	p	NN	NN	_	13	dep	_	_
16	less	less	JJR	JJR	_	15	amod	_	_
17	than	than	IN	IN	_	18	case	_	_
18	0.0001	0.0001	CD	CD	_	16	nmod	_	_
19	)	)	-RRB-	-RRB-	_	15	punct	_	_
20	,	,	,	,	_	5	punct	_	_
21	and	and	CC	CC	_	5	cc	_	_
22	an	a	DT	DT	_	24	det	_	_
23	inverse	inverse	JJ	JJ	_	24	amod	_	_
24	correlation	correlation	NN	NN	_	5	conj	_	_
25	between	between	IN	IN	_	26	case	_	_
26	inflammation	inflammation	NN	NN	_	24	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	oestrogen	oestrogen	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	OR	or	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	positivity	positivity	NN	NN	_	26	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	P	p	NN	NN	_	33	dep	_	_
36	less	less	JJR	JJR	_	35	amod	_	_
37	than	than	IN	IN	_	38	case	_	_
38	0.05	0.05	CD	CD	_	36	nmod	_	_
39	)	)	-RRB-	-RRB-	_	35	punct	_	_
40	as	as	RB	RB	_	26	cc	_	_
41	well	well	RB	RB	_	40	mwe	_	_
42	as	as	IN	IN	_	40	mwe	_	_
43	inflammation	inflammation	NN	NN	_	26	conj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	progesterone	progesterone	NN	NN	_	46	compound	_	_
46	receptor	receptor	NN	NN	_	50	compound	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	PR	pr	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	positivity	positivity	NN	NN	_	43	conj	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	P	p	NN	NN	_	50	dep	_	_
53	less	less	JJR	JJR	_	52	amod	_	_
54	than	than	IN	IN	_	55	case	_	_
55	0.05	0.05	CD	CD	_	53	nmod	_	_
56	)	)	-RRB-	-RRB-	_	52	punct	_	_
57	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	percentage	percentage	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	OKT8+	okt8+	JJ	JJ	_	8	amod	_	_
6	suppressor/cytotoxic	suppressor/cytotoxic	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	when	when	WRB	WRB	_	13	advmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	inflammation	inflammation	NN	NN	_	13	nsubj	_	_
13	expanded	expand	VBD	VBD	_	9	advcl	_	_
14	from	from	IN	IN	_	15	case	_	_
15	scanty	scanty	JJ	JJ	_	13	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	moderate	moderate	JJ	JJ	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	P	p	NN	NN	_	17	dep	_	_
20	less	less	JJR	JJR	_	19	amod	_	_
21	than	than	IN	IN	_	22	case	_	_
22	0.02	0.02	CD	CD	_	20	nmod	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	diameter	diameter	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	PCVs	pcv	NNS	NNS	_	2	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	increasing	increase	VBG	VBG	_	11	amod	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	infiltrate	infiltrate	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	P	p	NN	NN	_	11	dep	_	_
14	less	less	JJR	JJR	_	13	amod	_	_
15	than	than	IN	IN	_	16	case	_	_
16	0.02	0.02	CD	CD	_	14	nmod	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	direct	direct	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	7	nsubj	_	_
7	exists	exist	VBZ	VBZ	_	0	root	_	_
8	between	between	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	diameter	diameter	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	PCVs	pcv	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	both	both	CC	CC	_	17	dep	_	_
16	the	the	DT	DT	_	17	det	_	_
17	percentage	percentage	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	OKT8+	okt8+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	P	p	NN	NN	_	22	dep	_	_
25	less	less	JJR	JJR	_	24	amod	_	_
26	than	than	IN	IN	_	27	case	_	_
27	0.04	0.04	CD	CD	_	25	nmod	_	_
28	)	)	-RRB-	-RRB-	_	24	punct	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	the	the	DT	DT	_	34	det	_	_
31	Leu-7+	leu-7+	JJ	JJ	_	34	amod	_	_
32	natural	natural	JJ	JJ	_	34	amod	_	_
33	killer	killer	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	22	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	P	p	NN	NN	_	34	dep	_	_
37	less	less	JJR	JJR	_	36	amod	_	_
38	than	than	IN	IN	_	39	case	_	_
39	0.03	0.03	CD	CD	_	37	nmod	_	_
40	)	)	-RRB-	-RRB-	_	36	punct	_	_
41	.	.	.	.	_	7	punct	_	_

1	Mapping	mapping	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	B-cell	b-cell	NN	NN	_	4	compound	_	_
4	epitopes	epitope	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	human	human	JJ	JJ	_	12	amod	_	_
8	hepatitis	hepatitis	NN	NN	_	12	compound	_	_
9	B	b	NN	NN	_	12	compound	_	_
10	virus	virus	NN	NN	_	12	compound	_	_
11	X	x	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immune	immune	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	17	nsubjpass	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	X	x	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	hepatitis	hepatitis	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	3	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HBV	hbv	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	studied	study	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	20	case	_	_
19	epitope	epitope	NN	NN	_	20	compound	_	_
20	mapping	mapping	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	using	use	VBG	VBG	_	17	advcl	_	_
23	a	a	DT	DT	_	24	det	_	_
24	set	set	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	MS2-HBx	ms2-hbx	NN	NN	_	28	compound	_	_
27	fusion	fusion	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	synthetic	synthetic	JJ	JJ	_	31	amod	_	_
31	peptides	peptide	NNS	NNS	_	28	conj	_	_
32	.	.	.	.	_	17	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	12	nsubj	_	_
2	in	in	IN	IN	_	3	case	_	_
3	sera	sera	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	acute	acute	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	chronic	chronic	JJ	JJ	_	7	conj	_	_
10	HBV	hbv	NN	NN	_	11	compound	_	_
11	infection	infection	NN	NN	_	7	dep	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	16	det	_	_
14	multispecific	multispecific	JJ	JJ	_	16	amod	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	12	punct	_	_

1	Each	each	DT	DT	_	2	det	_	_
2	serum	serum	NN	NN	_	3	nsubj	_	_
3	contained	contain	VBD	VBD	_	0	root	_	_
4	antibodies	antibody	NNS	NNS	_	3	dobj	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	set	set	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	epitopes	epitope	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	which	which	WDT	WDT	_	15	nsubj	_	_
13	taken	take	VBN	VBN	_	15	csubj	_	_
14	together	together	RB	RB	_	13	advmod	_	_
15	cover	cover	VBP	VBP	_	8	acl:relcl	_	_
16	most	most	JJS	JJS	_	15	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	HBx	hbx	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Some	some	DT	DT	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	epitopes	epitope	NNS	NNS	_	1	nmod	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	detectable	detectable	JJ	JJ	_	0	root	_	_
7	only	only	RB	RB	_	9	advmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	immunoblotting	immunoblot	VBG	VBG	_	6	advcl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	fusion	fusion	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	nmod	_	_
13	;	;	:	:	_	6	punct	_	_
14	others	other	NNS	NNS	_	16	nsubj	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	detectable	detectable	JJ	JJ	_	6	parataxis	_	_
17	only	only	RB	RB	_	22	advmod	_	_
18	by	by	IN	IN	_	22	case	_	_
19	an	a	DT	DT	_	22	det	_	_
20	enzyme-linked	enzyme-linked	JJ	JJ	_	22	amod	_	_
21	immunosorbent	immunosorbent	JJ	JJ	_	22	amod	_	_
22	assay	assay	NN	NN	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	ELISA	elisa	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	with	with	IN	IN	_	28	case	_	_
27	synthetic	synthetic	JJ	JJ	_	28	amod	_	_
28	peptides	peptide	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	carboxy-terminal	carboxy-terminal	JJ	JJ	_	3	amod	_	_
3	half	half	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	HBx	hbx	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	preferentially	preferentially	RB	RB	_	10	advmod	_	_
10	recognized	recognize	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	antibodies	antibody	NNS	NNS	_	10	nmod	_	_
13	from	from	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	chronic	chronic	JJ	JJ	_	17	amod	_	_
17	hepatitis	hepatitis	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	contained	contain	VBD	VBD	_	10	conj	_	_
20	a	a	DT	DT	_	24	det	_	_
21	short	short	JJ	JJ	_	24	amod	_	_
22	immunodominant	immunodominant	JJ	JJ	_	24	amod	_	_
23	antigenic	antigenic	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	19	dobj	_	_
25	with	with	IN	IN	_	31	case	_	_
26	at	at	IN	IN	_	27	case	_	_
27	least	least	JJS	JJS	_	28	nmod:npmod	_	_
28	two	two	CD	CD	_	31	nummod	_	_
29	major	major	JJ	JJ	_	31	amod	_	_
30	nonoverlapping	nonoverlapping	JJ	JJ	_	31	amod	_	_
31	epitopes	epitope	NNS	NNS	_	24	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Anti-HBx	anti-hbx	JJ	JJ	_	3	amod	_	_
2	antibody	antibody	NN	NN	_	3	compound	_	_
3	titers	titer	NNS	NNS	_	10	nsubj	_	_
4	as	as	IN	IN	_	5	mark	_	_
5	revealed	reveal	VBN	VBN	_	3	dep	_	_
6	by	by	IN	IN	_	8	case	_	_
7	peptide	peptide	NN	NN	_	8	compound	_	_
8	ELISAs	elisa	NNS	NNS	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	highest	highest	JJS	JJS	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	most	most	RBS	RBS	_	13	advmod	_	_
13	frequent	frequent	JJ	JJ	_	10	conj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	10	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	chronic	chronic	JJ	JJ	_	18	amod	_	_
18	hepatitis	hepatitis	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	usually	usually	RB	RB	_	21	advmod	_	_
21	low	low	JJ	JJ	_	10	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	acutely	acutely	RB	RB	_	24	advmod	_	_
24	infected	infected	JJ	JJ	_	25	amod	_	_
25	patients	patient	NNS	NNS	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	asymptomatic	asymptomatic	JJ	JJ	_	28	amod	_	_
28	carriers	carrier	NNS	NNS	_	25	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	dep	_	_
5	remarkable	remarkable	JJ	JJ	_	6	amod	_	_
6	qualitative	qualitative	JJ	JJ	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	quantitative	quantitative	JJ	JJ	_	6	conj	_	_
9	heterogeneity	heterogeneity	NN	NN	_	6	dep	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	humoral	humoral	JJ	JJ	_	15	amod	_	_
13	HBx	hbx	NN	NN	_	15	compound	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	6	nmod	_	_
16	which	which	WDT	WDT	_	19	nsubjpass	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	monitored	monitor	VBN	VBN	_	15	acl:relcl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	HBx-specific	hbx-specific	JJ	JJ	_	23	amod	_	_
22	peptide	peptide	NN	NN	_	23	compound	_	_
23	ELISAs	elisa	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	tests	test	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	become	become	VB	VB	_	0	root	_	_
5	useful	useful	JJ	JJ	_	7	amod	_	_
6	diagnostic	diagnostic	JJ	JJ	_	5	dep	_	_
7	tools	tool	NNS	NNS	_	4	xcomp	_	_
8	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
3	virus	virus	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	EBV	ebv	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	ORI1yt	ori1yt	NN	NN	_	8	compound	_	_
8	enhancer	enhancer	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	B-cell	b-cell	NN	NN	_	12	nmod:npmod	_	_
12	specific	specific	JJ	JJ	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	does	do	VBZ	VBZ	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	respond	respond	VB	VB	_	12	conj	_	_
17	synergistically	synergistically	RB	RB	_	16	xcomp	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	EBV	ebv	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	16	nmod	_	_
23	R	r	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	Z	z	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	DR	dr	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	located	located	JJ	JJ	_	0	root	_	_
8	upstream	upstream	RB	RB	_	7	advmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	PstI	psti	NN	NN	_	12	compound	_	_
12	repeats	repeat	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	in	in	IN	IN	_	16	case	_	_
16	addition	addition	NN	NN	_	23	nmod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TATA	tata	NN	NN	_	20	compound	_	_
20	box	box	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	it	it	PRP	PRP	_	23	nsubj	_	_
23	contains	contain	VBZ	VBZ	_	7	conj	_	_
24	an	a	DT	DT	_	26	det	_	_
25	upstream	upstream	JJ	JJ	_	26	amod	_	_
26	region	region	NN	NN	_	23	dobj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	positions	position	NNS	NNS	_	26	dep	_	_
29	-69	-69	CD	CD	_	31	compound	_	_
30	to	to	TO	TO	_	31	dep	_	_
31	-220	-220	CD	CD	_	28	nummod	_	_
32	)	)	-RRB-	-RRB-	_	28	punct	_	_
33	responsive	responsive	JJ	JJ	_	26	amod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	EB1	eb1	NN	NN	_	36	compound	_	_
36	(Z)	(z)	NN	NN	_	33	nmod	_	_
37	(	(	-LRB-	-LRB-	_	41	punct	_	_
38	the	the	DT	DT	_	41	det	_	_
39	BZLF1-encoded	bzlf1-encoded	JJ	JJ	_	41	amod	_	_
40	transcription	transcription	NN	NN	_	41	compound	_	_
41	factor	factor	NN	NN	_	36	dep	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	and	and	CC	CC	_	36	cc	_	_
44	an	a	DT	DT	_	45	det	_	_
45	enhancer	enhancer	NN	NN	_	36	conj	_	_
46	with	with	IN	IN	_	50	case	_	_
47	two	two	CD	CD	_	50	nummod	_	_
48	functionally	functionally	RB	RB	_	49	advmod	_	_
49	distinct	distinct	JJ	JJ	_	50	amod	_	_
50	domains	domain	NNS	NNS	_	45	nmod	_	_
51	,	,	,	,	_	50	punct	_	_
52	A	a	NN	NN	_	50	appos	_	_
53	and	and	CC	CC	_	52	cc	_	_
54	B	b	NN	NN	_	52	conj	_	_
55	.	.	.	.	_	7	punct	_	_

1	Domain	domain	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	described	describe	VBN	VBN	_	0	root	_	_
6	as	as	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	B-cell-specific	b-cell-specific	JJ	JJ	_	10	amod	_	_
9	EB1-responsive	eb1-responsive	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	P.M.Lieberman	P.M.Lieberman	NNP	NNP	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	J.M.Hardwick	J.M.Hardwick	NNP	NNP	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	S.D.Hayward	S.D.Hayward	NNP	NNP	_	12	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	J.Virol.63	J.Virol.63	NNP	NNP	_	12	appos	_	_
20	:	:	:	:	_	12	punct	_	_
21	3040-3050	3040-3050	CD	CD	_	12	dep	_	_
22	,	,	,	,	_	12	punct	_	_
23	1989	1989	CD	CD	_	12	amod	_	_
24	)	)	-RRB-	-RRB-	_	12	punct	_	_
25	activated	activate	VBN	VBN	_	10	dep	_	_
26	synergistically	synergistically	RB	RB	_	25	advmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	EB1	eb1	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	R	r	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	an	a	DT	DT	_	35	det	_	_
33	EBV	ebv	NN	NN	_	35	compound	_	_
34	early	early	JJ	JJ	_	35	amod	_	_
35	product	product	NN	NN	_	28	appos	_	_
36	encoded	encode	VBN	VBN	_	35	acl	_	_
37	by	by	IN	IN	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	open	open	JJ	JJ	_	42	amod	_	_
40	reading	reading	NN	NN	_	42	compound	_	_
41	frame	frame	NN	NN	_	42	compound	_	_
42	BRLF1	brlf1	NN	NN	_	36	nmod	_	_
43	(	(	-LRB-	-LRB-	_	45	punct	_	_
44	M.A.	M.A.	NNP	NNP	_	45	compound	_	_
45	Cox	Cox	NNP	NNP	_	42	dep	_	_
46	,	,	,	,	_	45	punct	_	_
47	J.Leahy	J.Leahy	NNP	NNP	_	45	conj	_	_
48	,	,	,	,	_	45	punct	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	J.M.Hardwick	J.M.Hardwick	NNP	NNP	_	45	conj	_	_
51	,	,	,	,	_	45	punct	_	_
52	J.Virol.64	J.Virol.64	NNP	NNP	_	45	appos	_	_
53	:	:	:	:	_	45	punct	_	_
54	313-321	313-321	CD	CD	_	45	dep	_	_
55	,	,	,	,	_	45	punct	_	_
56	1990	1990	CD	CD	_	45	amod	_	_
57	)	)	-RRB-	-RRB-	_	45	punct	_	_
58	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	domain	domain	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	R-responsive	r-responsive	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	2	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HeLa	hela	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	is	be	VBZ	VBZ	_	21	cop	_	_
16	therefore	therefore	RB	RB	_	21	advmod	_	_
17	not	not	RB	RB	_	21	neg	_	_
18	an	a	DT	DT	_	21	det	_	_
19	EB1-responsive	eb1-responsive	JJ	JJ	_	21	amod	_	_
20	B-cell-specific	b-cell-specific	JJ	JJ	_	21	amod	_	_
21	element	element	NN	NN	_	10	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	EB1-binding	eb1-binding	JJ	JJ	_	7	amod	_	_
7	site	site	NN	NN	_	4	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	ZRE-B	zre-b	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	located	located	JJ	JJ	_	7	amod	_	_
12	within	within	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	R-responsive	r-responsive	JJ	JJ	_	16	amod	_	_
15	enhancer	enhancer	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	ZRE-B	zre-b	NN	NN	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	deleted	delete	VBN	VBN	_	0	root	_	_
5	without	without	IN	IN	_	6	mark	_	_
6	affecting	affect	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	R-dependent	r-dependent	JJ	JJ	_	10	amod	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	cooperation	cooperation	NN	NN	_	4	nsubj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	synergy	synergy	NN	NN	_	6	conj	_	_
9	between	between	IN	IN	_	10	case	_	_
10	R	r	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	EB1	eb1	NN	NN	_	10	conj	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	activating	activate	VBG	VBG	_	4	advcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	14	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ZRE-B	zre-b	NN	NN	_	17	dep	_	_
20	plus	plus	CC	CC	_	19	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	R-responsive	r-responsive	JJ	JJ	_	23	amod	_	_
23	element	element	NN	NN	_	19	conj	_	_
24	)	)	-RRB-	-RRB-	_	19	punct	_	_
25	positioned	positioned	JJ	JJ	_	17	amod	_	_
26	as	as	IN	IN	_	28	case	_	_
27	an	a	DT	DT	_	28	det	_	_
28	enhancer	enhancer	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	ZRE-B	zre-b	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	part	part	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	R-inducible	r-inducible	JJ	JJ	_	9	amod	_	_
9	enhancer	enhancer	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	tested	test	VBN	VBN	_	0	root	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	subregions	subregion	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	DR	dr	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	5	nmod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	domain	domain	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	5	punct	_	_
13	either	either	CC	CC	_	5	dep	_	_
14	alone	alone	RB	RB	_	13	dep	_	_
15	or	or	CC	CC	_	13	cc	_	_
16	in	in	IN	IN	_	17	case	_	_
17	combination	combination	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	5	punct	_	_
19	for	for	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	capacity	capacity	NN	NN	_	5	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	transmit	transmit	VB	VB	_	21	acl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	R-activating	r-activating	JJ	JJ	_	26	amod	_	_
26	signal	signal	NN	NN	_	23	dobj	_	_
27	to	to	TO	TO	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	rabbit	rabbit	NN	NN	_	31	compound	_	_
30	beta-globin	beta-globin	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	R-responsive	r-responsive	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	composed	compose	VBN	VBN	_	2	ccomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	four	four	CD	CD	_	11	nummod	_	_
11	protoenhancers	protoenhancer	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	span	span	VBP	VBP	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	whole	whole	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	protoenhancers	protoenhancer	NNS	NNS	_	5	nsubj	_	_
3	alone	alone	RB	RB	_	2	advmod	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	weakly	weakly	JJ	JJ	_	0	root	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	responsive	responsive	JJ	JJ	_	5	conj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	R	r	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	One	one	CD	CD	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	protoenhancers	protoenhancer	NNS	NNS	_	1	nmod	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	overlapping	overlap	VBG	VBG	_	8	amod	_	_
8	palindromes	palindrome	NNS	NNS	_	5	dobj	_	_
9	5'-TTGTCCcgtGGACAAaTGTCC-3'	5'-ttgtcccgtggacaaatgtcc-3'	NN	NN	_	8	dep	_	_
10	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	one	one	CD	CD	_	4	nummod	_	_
4	palindrome	palindrome	NN	NN	_	17	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	either	either	CC	CC	_	4	dep	_	_
7	alone	alone	RB	RB	_	6	dep	_	_
8	or	or	CC	CC	_	6	cc	_	_
9	duplicated	duplicated	JJ	JJ	_	6	conj	_	_
10	,	,	,	,	_	4	punct	_	_
11	or	or	CC	CC	_	4	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	overlapping	overlap	VBG	VBG	_	14	amod	_	_
14	palindromes	palindrome	NNS	NNS	_	4	conj	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	respond	respond	VB	VB	_	0	root	_	_
18	to	to	TO	TO	_	19	case	_	_
19	R	r	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	17	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	5	compound	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	vpr	vpr	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	virion-associated	virion-associated	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	vpr	vpr	NN	NN	_	3	compound	_	_
3	product	product	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	3	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HIV-1	hiv-1	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	acts	act	VBZ	VBZ	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	trans	trans	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	accelerate	accelerate	VB	VB	_	14	xcomp	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	replication	replication	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	cytopathic	cytopathic	JJ	JJ	_	23	amod	_	_
23	effect	effect	NN	NN	_	20	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	it	it	PRP	PRP	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
8	viral	viral	JJ	JJ	_	9	amod	_	_
9	particle	particle	NN	NN	_	10	nsubj	_	_
10	contains	contain	VBZ	VBZ	_	4	ccomp	_	_
11	multiple	multiple	JJ	JJ	_	12	amod	_	_
12	copies	copy	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	vpr	vpr	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	vpr	vpr	NN	NN	_	3	compound	_	_
3	product	product	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	the	the	DT	DT	_	8	det	_	_
6	first	first	JJ	JJ	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	HIV-1	hiv-1	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	8	acl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	virus	virus	NN	NN	_	17	compound	_	_
17	particle	particle	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	3	nsubj	_	_
3	raises	raise	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	vpr	vpr	NN	NN	_	8	nsubj	_	_
8	acts	act	VBZ	VBZ	_	5	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	facilitate	facilitate	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	early	early	JJ	JJ	_	13	amod	_	_
13	steps	step	NNS	NNS	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	infection	infection	NN	NN	_	13	nmod	_	_
16	before	before	IN	IN	_	22	mark	_	_
17	de	de	FW	FW	_	21	amod	_	_
18	novo	novo	FW	FW	_	17	dep	_	_
19	viral	viral	JJ	JJ	_	21	amod	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	synthesis	synthesis	NN	NN	_	22	nsubj	_	_
22	occurs	occur	VBZ	VBZ	_	10	advcl	_	_
23	.	.	.	.	_	3	punct	_	_

1	Type	type	NN	NN	_	5	compound	_	_
2	II	ii	CD	CD	_	5	nummod	_	_
3	estrogen	estrogen	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	:	:	:	:	_	5	punct	_	_
13	variations	variation	NNS	NNS	_	5	dep	_	_
14	during	during	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	menstrual	menstrual	JJ	JJ	_	17	amod	_	_
17	cycle	cycle	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
8	blood	blood	NN	NN	_	10	compound	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	14	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PBMC	pbmc	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	contain	contain	VBP	VBP	_	4	ccomp	_	_
15	type	type	NN	NN	_	14	dobj	_	_
16	II	ii	CD	CD	_	19	nummod	_	_
17	estrogen	estrogen	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	15	dep	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	type	type	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	23	nummod	_	_
23	EBS	eb	NNS	NNS	_	15	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	fluctuations	fluctuation	NNS	NNS	_	16	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	type	type	NN	NN	_	10	compound	_	_
9	II	ii	CD	CD	_	10	nummod	_	_
10	EBS	eb	NNS	NNS	_	6	nmod	_	_
11	during	during	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	menstrual	menstrual	JJ	JJ	_	14	amod	_	_
14	cycle	cycle	NN	NN	_	6	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	analyzed	analyze	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	21	case	_	_
18	6	6	CD	CD	_	21	nummod	_	_
19	normally	normally	RB	RB	_	20	advmod	_	_
20	menstruating	menstruate	VBG	VBG	_	21	amod	_	_
21	women	woman	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	Approximately	approximately	RB	RB	_	3	advmod	_	_
2	3	3	CD	CD	_	3	compound	_	_
3	times	time	NNS	NNS	_	5	dep	_	_
4	higher	higher	JJR	JJR	_	3	dep	_	_
5	levels	level	NNS	NNS	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	type	type	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	EBS	eb	NNS	NNS	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	periovulatory	periovulatory	JJ	JJ	_	15	amod	_	_
15	period	period	NN	NN	_	11	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	respect	respect	NN	NN	_	11	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	follicular	follicular	JJ	JJ	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	luteal	luteal	JJ	JJ	_	20	conj	_	_
23	phases	phase	NNS	NNS	_	20	dep	_	_
24	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	postmenopausal	postmenopausal	JJ	JJ	_	3	amod	_	_
3	women	woman	NNS	NNS	_	11	nmod	_	_
4	the	the	DT	DT	_	9	det	_	_
5	mean	mean	NN	NN	_	9	compound	_	_
6	type	type	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	EBS	eb	NNS	NNS	_	9	compound	_	_
9	levels	level	NNS	NNS	_	11	nsubj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	similar	similar	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	those	those	DT	DT	_	11	nmod	_	_
14	observed	observe	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	follicular	follicular	JJ	JJ	_	18	amod	_	_
18	phase	phase	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cycle	cycle	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	3	3	CD	CD	_	6	nummod	_	_
5	postmenopausal	postmenopausal	JJ	JJ	_	6	amod	_	_
6	patients	patient	NNS	NNS	_	14	nmod	_	_
7	a	a	DT	DT	_	9	det	_	_
8	short	short	JJ	JJ	_	9	amod	_	_
9	course	course	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	estrogen	estrogen	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	tamoxifen	tamoxifen	NN	NN	_	11	conj	_	_
14	resulted	result	VBD	VBD	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	marked	marked	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	type	type	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	EBS	eb	NNS	NNS	_	23	compound	_	_
23	levels	level	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	Tamoxifen	tamoxifen	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	compete	compete	VB	VB	_	4	xcomp	_	_
7	with	with	IN	IN	_	9	case	_	_
8	17	17	CD	CD	_	9	nummod	_	_
9	beta-estradiol	beta-estradiol	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	EBS	eb	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	PBMC	pbmc	NNS	NNS	_	13	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	although	although	IN	IN	_	21	mark	_	_
18	to	to	TO	TO	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	lesser	lesser	JJR	JJR	_	21	amod	_	_
21	extent	extent	NN	NN	_	4	advcl	_	_
22	than	than	IN	IN	_	23	case	_	_
23	diethylstilbestrol	diethylstilbestrol	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	mitogenic	mitogenic	JJ	JJ	_	4	amod	_	_
4	agents	agent	NNS	NNS	_	1	nmod	_	_
5	upon	upon	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	action	action	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	tonsillar	tonsillar	NN	NN	_	11	compound	_	_
11	T-lymphocytes	t-lymphocyte	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	treatment	treatment	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	tonsillar	tonsillar	NN	NN	_	6	compound	_	_
6	T-lymphocytes	t-lymphocyte	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	4-phorbol	4-phorbol	NN	NN	_	10	compound	_	_
9	12-myristate	12-myristate	NN	NN	_	10	compound	_	_
10	13-acetate	13-acetate	NN	NN	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMA	pma	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	2	punct	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	about	about	RB	RB	_	18	advmod	_	_
18	two	two	CD	CD	_	19	dep	_	_
19	fold	fold	JJ	JJ	_	20	dep	_	_
20	increase	increase	NN	NN	_	15	nmod	_	_
21	in	in	IN	IN	_	27	case	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	GR	gr	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	number	number	NN	NN	_	20	nmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	without	without	IN	IN	_	32	case	_	_
30	any	any	DT	DT	_	32	det	_	_
31	significant	significant	JJ	JJ	_	32	amod	_	_
32	change	change	NN	NN	_	20	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	receptor	receptor	NN	NN	_	36	compound	_	_
36	affinity	affinity	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	3	nsubj	_	_
3	disappeared	disappear	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	cycloheximide	cycloheximide	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Alone	alone	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	PMA	pma	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	calcium	calcium	NN	NN	_	7	compound	_	_
6	ionophore	ionophore	NN	NN	_	7	compound	_	_
7	A23187	a23187	NN	NN	_	3	conj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affect	affect	VB	VB	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	10	cc	_	_
13	together	together	RB	RB	_	14	advmod	_	_
14	stimulated	stimulate	VBD	VBD	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	like	like	IN	IN	_	17	case	_	_
17	phytohaemagglutinin	phytohaemagglutinin	NN	NN	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PHA	pha	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	10	punct	_	_
22	leucine	leucine	NN	NN	_	10	conj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	,	,	,	,	_	22	punct	_	_
25	in	in	IN	IN	_	26	case	_	_
26	particular	particular	JJ	JJ	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	thymidine	thymidine	NN	NN	_	22	conj	_	_
29	incorporation	incorporation	NN	NN	_	22	dep	_	_
30	.	.	.	.	_	10	punct	_	_

1	PMA	pma	NN	NN	_	2	nsubj	_	_
2	enhanced	enhance	VBD	VBD	_	0	root	_	_
3	slightly	slightly	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	stimulatory	stimulatory	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PHA	pha	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Alone	alone	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	agents	agent	NNS	NNS	_	5	nsubj	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	alter	alter	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	suppressive	suppressive	JJ	JJ	_	10	amod	_	_
10	effect	effect	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	dexamethasone	dexamethasone	NN	NN	_	10	nmod	_	_
13	on	on	IN	IN	_	14	case	_	_
14	thymidine	thymidine	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	leucine	leucine	NN	NN	_	14	conj	_	_
17	incorporation	incorporation	NN	NN	_	14	dep	_	_
18	;	;	:	:	_	5	punct	_	_
19	however	however	RB	RB	_	25	advmod	_	_
20	,	,	,	,	_	25	punct	_	_
21	PMA-A23187	pma-a23187	JJ	JJ	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	PMA-PHA	pma-pha	JJ	JJ	_	21	conj	_	_
24	combinations	combination	NNS	NNS	_	25	nsubj	_	_
25	appeared	appear	VBD	VBD	_	5	parataxis	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	antagonize	antagonize	VB	VB	_	25	xcomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	suppression	suppression	NN	NN	_	27	dobj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	dexamethasone	dexamethasone	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	10	nsubj	_	_
4	from	from	IN	IN	_	8	case	_	_
5	vitamin	vitamin	NN	NN	_	8	compound	_	_
6	D-dependent	d-dependent	JJ	JJ	_	8	amod	_	_
7	rickets	rickets	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	3	nmod	_	_
9	II	ii	CD	CD	_	8	nummod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	functional	functional	JJ	JJ	_	12	amod	_	_
12	defects	defect	NNS	NNS	_	10	dobj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	1	1	CD	CD	_	18	nummod	_	_
16	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	18	compound	_	_
17	D3	d3	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	established	establish	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	8	case	_	_
7	five	five	CD	CD	_	8	nummod	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	14	case	_	_
10	vitamin	vitamin	NN	NN	_	14	compound	_	_
11	D-dependent	d-dependent	JJ	JJ	_	14	amod	_	_
12	rickets	rickets	NN	NN	_	14	compound	_	_
13	,	,	,	,	_	14	punct	_	_
14	type	type	NN	NN	_	8	nmod	_	_
15	II	ii	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	VDDR-II	vddr-ii	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	lines	line	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	established	establish	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	infection	infection	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	T-lymphotrophic	t-lymphotrophic	JJ	JJ	_	11	amod	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	6	nmod	_	_
12	I	i	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HTLV-I	htlv-i	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	4	punct	_	_

1	Binding	binding	NN	NN	_	17	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	-LSB-3H-RSB-1	-lsb-3h-rsb-1	NN	NN	_	5	compound	_	_
4	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	to	to	TO	TO	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	receptor	receptor	NN	NN	_	1	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	compared	compare	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	studies	study	NNS	NNS	_	17	nmod	_	_
21	using	use	VBG	VBG	_	17	xcomp	_	_
22	a	a	DT	DT	_	25	det	_	_
23	T-lymphocyte	t-lymphocyte	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	21	dobj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	S-LB1	s-lb1	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	from	from	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	normal	normal	JJ	JJ	_	32	amod	_	_
32	individual	individual	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	S-LB1	s-lb1	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	comparable	comparable	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	well-characterized	well-characterized	JJ	JJ	_	14	amod	_	_
11	chick	chick	NN	NN	_	14	compound	_	_
12	intestinal	intestinal	JJ	JJ	_	14	amod	_	_
13	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	7	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	terms	term	NNS	NNS	_	7	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	ligand	ligand	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	16	nmod	_	_
21	affinity	affinity	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	capacity	capacity	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
26	mobility	mobility	NN	NN	_	20	conj	_	_
27	on	on	IN	IN	_	31	case	_	_
28	5-20	5-20	CD	CD	_	29	dep	_	_
29	%	%	NN	NN	_	31	dep	_	_
30	sucrose	sucrose	NN	NN	_	31	compound	_	_
31	gradients	gradient	NNS	NNS	_	26	nmod	_	_
32	,	,	,	,	_	20	punct	_	_
33	and	and	CC	CC	_	20	cc	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	adsorption	adsorption	NN	NN	_	20	conj	_	_
36	to	to	TO	TO	_	35	acl	_	_
37	and	and	CC	CC	_	35	cc	_	_
38	elution	elution	NN	NN	_	39	compound	_	_
39	properties	property	NNS	NNS	_	35	conj	_	_
40	from	from	IN	IN	_	39	acl	_	_
41	DNA-cellulose	dna-cellulose	NN	NN	_	35	dep	_	_
42	.	.	.	.	_	7	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	17	nsubj	_	_
4	established	establish	VBN	VBN	_	3	acl	_	_
5	from	from	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	VDDR-II	vddr-ii	NN	NN	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Rh-VDR	rh-vdr	NN	NN	_	8	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	Sh-VDR	sh-vdr	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	Ab-VDR	ab-vdr	NN	NN	_	10	conj	_	_
16	)	)	-RRB-	-RRB-	_	10	punct	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	no	no	DT	DT	_	20	neg	_	_
19	specific	specific	JJ	JJ	_	20	amod	_	_
20	binding	binding	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	receptor	receptor	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	treatment	treatment	NN	NN	_	36	nsubj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	cultured	culture	VBN	VBN	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	with	with	IN	IN	_	33	case	_	_
33	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	27	nmod	_	_
34	did	do	VBD	VBD	_	36	aux	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	stimulate	stimulate	VB	VB	_	17	conj	_	_
37	production	production	NN	NN	_	36	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	24,25-dihydroxy-vitamin	24,25-dihydroxy-vitamin	NN	NN	_	40	compound	_	_
40	D3	d3	NN	NN	_	37	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	24,25(OH)2D3	24,25(oh)2d3	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	37	punct	_	_
45	a	a	DT	DT	_	46	det	_	_
46	response	response	NN	NN	_	37	appos	_	_
47	which	which	WDT	WDT	_	49	nsubj	_	_
48	is	be	VBZ	VBZ	_	49	cop	_	_
49	diagnostic	diagnostic	JJ	JJ	_	46	acl:relcl	_	_
50	of	of	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	presence	presence	NN	NN	_	49	nmod	_	_
53	of	of	IN	IN	_	57	case	_	_
54	a	a	DT	DT	_	57	det	_	_
55	functional	functional	JJ	JJ	_	57	amod	_	_
56	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	57	compound	_	_
57	receptor	receptor	NN	NN	_	52	nmod	_	_
58	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	a	a	DT	DT	_	5	det	_	_
3	fourth	fourth	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	13	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	A1-VDR	a1-vdr	NN	NN	_	13	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	receptor	receptor	NN	NN	_	7	appos	_	_
11	for	for	IN	IN	_	12	case	_	_
12	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	10	nmod	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	low	low	JJ	JJ	_	17	amod	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	capacity	capacity	NN	NN	_	13	dobj	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	25(OH)D3-24-hydroxylase	25(oh)d3-24-hydroxylase	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	23	nsubj	_	_
21	was	be	VBD	VBD	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	detectable	detectable	JJ	JJ	_	13	conj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Induction	induction	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	24,25-(OH)2D3	24,25-(oh)2d3	NN	NN	_	4	compound	_	_
4	synthesis	synthesis	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	fifth	fifth	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	designated	designate	VBN	VBN	_	13	acl	_	_
16	Ro-VDR	ro-vdr	NN	NN	_	15	xcomp	_	_
17	,	,	,	,	_	8	punct	_	_
18	although	although	IN	IN	_	25	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	sensitivity	sensitivity	NN	NN	_	25	nsubj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	hormone	hormone	NN	NN	_	23	compound	_	_
23	treatment	treatment	NN	NN	_	20	nmod	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	lower	lower	JJR	JJR	_	8	advcl	_	_
26	than	than	IN	IN	_	31	case	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	control	control	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	line	line	NN	NN	_	25	nmod	_	_
32	from	from	IN	IN	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	normal	normal	JJ	JJ	_	35	amod	_	_
35	donor	donor	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	capacity	capacity	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	receptor	receptor	NN	NN	_	2	nmod	_	_
6	for	for	IN	IN	_	7	case	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	low	low	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	Ro-VDR	ro-vdr	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	all	all	DT	DT	_	4	det	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	16	nmod	_	_
5	where	where	WRB	WRB	_	12	advmod	_	_
6	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	12	nsubj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	receptor	receptor	NN	NN	_	7	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	detectable	detectable	JJ	JJ	_	4	acl:relcl	_	_
13	,	,	,	,	_	16	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	receptor	receptor	NN	NN	_	16	nsubj	_	_
16	had	have	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	20	det	_	_
18	typical	typical	JJ	JJ	_	20	amod	_	_
19	sedimentation	sedimentation	NN	NN	_	20	compound	_	_
20	coefficient	coefficient	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	3.7	3.7	CD	CD	_	23	nummod	_	_
23	S	s	NN	NN	_	20	nmod	_	_
24	on	on	IN	IN	_	28	case	_	_
25	sucrose	sucrose	NN	NN	_	28	compound	_	_
26	density	density	NN	NN	_	28	compound	_	_
27	gradient	gradient	NN	NN	_	28	compound	_	_
28	analysis	analysis	NN	NN	_	20	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	Binding	binding	NN	NN	_	10	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	elution	elution	NN	NN	_	1	conj	_	_
4	properties	property	NNS	NNS	_	1	dep	_	_
5	to	to	TO	TO	_	6	case	_	_
6	DNA-cellulose	dna-cellulose	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	however	however	RB	RB	_	10	advmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	differed	differ	VBD	VBD	_	0	root	_	_
11	from	from	IN	IN	_	12	case	_	_
12	normal	normal	JJ	JJ	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	Ro-VDR	ro-vdr	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	A1-VDR	a1-vdr	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	conj	_	_
19	where	where	WRB	WRB	_	23	advmod	_	_
20	elution	elution	NN	NN	_	23	nsubj	_	_
21	from	from	IN	IN	_	22	case	_	_
22	DNA-cellulose	dna-cellulose	NN	NN	_	20	nmod	_	_
23	occurred	occur	VBD	VBD	_	15	acl:relcl	_	_
24	at	at	IN	IN	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	lower	lower	JJR	JJR	_	28	amod	_	_
27	salt	salt	NN	NN	_	28	compound	_	_
28	concentration	concentration	NN	NN	_	23	nmod	_	_
29	than	than	IN	IN	_	31	mark	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	typical	typical	JJ	JJ	_	23	advcl	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	35	compound	_	_
35	receptor	receptor	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	While	while	IN	IN	_	4	mark	_	_
2	Ro-VDR	ro-vdr	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	26	advcl	_	_
5	typical	typical	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	localization	localization	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	unoccupied	unoccupied	JJ	JJ	_	12	amod	_	_
11	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	26	punct	_	_
14	neither	neither	CC	CC	_	16	cc:preconj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	unoccupied	unoccupied	JJ	JJ	_	26	nsubj	_	_
17	nor	nor	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	occupied	occupied	JJ	JJ	_	16	conj	_	_
20	receptor	receptor	NN	NN	_	16	dep	_	_
21	from	from	IN	IN	_	23	case	_	_
22	A1-VDR	a1-vdr	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	was	be	VBD	VBD	_	26	cop	_	_
25	completely	completely	RB	RB	_	26	advmod	_	_
26	localized	localized	JJ	JJ	_	0	root	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	nucleus	nucleus	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	26	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	series	series	NN	NN	_	8	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	studies	study	NNS	NNS	_	3	nmod	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	found	find	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	35	mark	_	_
10	modulation	modulation	NN	NN	_	35	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mRNAs	mrna	NNS	NNS	_	13	nmod	_	_
17	coding	code	VBG	VBG	_	16	acl	_	_
18	for	for	IN	IN	_	22	case	_	_
19	both	both	CC	CC	_	22	cc:preconj	_	_
20	the	the	DT	DT	_	22	det	_	_
21	c-myc	c-myc	NN	NN	_	22	compound	_	_
22	oncogene	oncogene	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	growth	growth	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	22	conj	_	_
27	known	know	VBN	VBN	_	26	acl	_	_
28	as	as	IN	IN	_	30	case	_	_
29	granulocyte-monocyte	granulocyte-monocyte	JJ	JJ	_	30	amod	_	_
30	colony	colony	NN	NN	_	27	nmod	_	_
31	stimulating	stimulating	NN	NN	_	30	dep	_	_
32	activity	activity	NN	NN	_	31	dobj	_	_
33	by	by	IN	IN	_	34	case	_	_
34	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	32	nmod	_	_
35	correlated	correlate	VBD	VBD	_	8	ccomp	_	_
36	with	with	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	39	compound	_	_
39	receptor	receptor	NN	NN	_	40	compound	_	_
40	status	status	NN	NN	_	35	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	these	these	DT	DT	_	43	det	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	8	punct	_	_

1	Use	use	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	1	nmod	_	_
6	will	will	MD	MD	_	7	aux	_	_
7	facilitate	facilitate	VB	VB	_	0	root	_	_
8	further	further	JJ	JJ	_	9	amod	_	_
9	study	study	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	molecular	molecular	JJ	JJ	_	15	amod	_	_
13	defect	defect	NN	NN	_	15	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	s	s	NNS	NNS	_	9	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	receptor	receptor	NN	NN	_	15	nmod	_	_
20	for	for	IN	IN	_	21	case	_	_
21	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	vitamin	vitamin	NN	NN	_	26	compound	_	_
24	D-dependent	d-dependent	JJ	JJ	_	26	amod	_	_
25	rickets	rickets	NN	NN	_	26	compound	_	_
26	type	type	NN	NN	_	21	nmod	_	_
27	II	ii	CD	CD	_	26	nummod	_	_
28	and	and	CC	CC	_	7	cc	_	_
29	will	will	MD	MD	_	30	aux	_	_
30	allow	allow	VB	VB	_	7	conj	_	_
31	a	a	DT	DT	_	32	det	_	_
32	correlation	correlation	NN	NN	_	30	dobj	_	_
33	with	with	IN	IN	_	34	case	_	_
34	impairment	impairment	NN	NN	_	32	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	cellular	cellular	JJ	JJ	_	37	amod	_	_
37	functions	function	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	second	second	JJ	JJ	_	7	amod	_	_
5	lymphoid-specific	lymphoid-specific	JJ	JJ	_	7	amod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	immunoglobulin	immunoglobulin	NN	NN	_	14	compound	_	_
13	heavy-chain	heavy-chain	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	19	mark	_	_
4	enhancer	enhancer	NN	NN	_	5	compound	_	_
5	elements	element	NNS	NNS	_	19	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	addition	addition	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	highly	highly	RB	RB	_	17	advmod	_	_
11	conserved	conserve	VBN	VBN	_	17	amod	_	_
12	octamer	octamer	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	OCTA	octa	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	-nucleotide	-nucleotide	JJ	JJ	_	17	amod	_	_
17	motif	motif	NN	NN	_	7	nmod	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	important	important	JJ	JJ	_	2	ccomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	lymphoid-specific	lymphoid-specific	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	immunoglobulin	immunoglobulin	NN	NN	_	30	compound	_	_
26	heavy-chain	heavy-chain	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	IgH	igh	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	gene	gene	NN	NN	_	22	nmod	_	_
31	,	,	,	,	_	2	punct	_	_
32	we	we	PRP	PRP	_	34	nsubj	_	_
33	have	have	VBP	VBP	_	34	aux	_	_
34	investigated	investigate	VBN	VBN	_	2	parataxis	_	_
35	the	the	DT	DT	_	36	det	_	_
36	effect	effect	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	38	mark	_	_
38	mutating	mutate	VBG	VBG	_	36	acl	_	_
39	the	the	DT	DT	_	41	det	_	_
40	binding	bind	VBG	VBG	_	41	amod	_	_
41	site	site	NN	NN	_	38	dobj	_	_
42	for	for	IN	IN	_	48	case	_	_
43	a	a	DT	DT	_	48	det	_	_
44	putative	putative	JJ	JJ	_	48	amod	_	_
45	additional	additional	JJ	JJ	_	48	amod	_	_
46	lymphoid-specific	lymphoid-specific	JJ	JJ	_	48	amod	_	_
47	transcription	transcription	NN	NN	_	48	compound	_	_
48	factor	factor	NN	NN	_	41	nmod	_	_
49	,	,	,	,	_	48	punct	_	_
50	designated	designate	VBN	VBN	_	48	acl	_	_
51	NF-microB	nf-microb	NN	NN	_	50	xcomp	_	_
52	,	,	,	,	_	41	punct	_	_
53	in	in	IN	IN	_	57	case	_	_
54	the	the	DT	DT	_	57	det	_	_
55	murine	murine	JJ	JJ	_	57	amod	_	_
56	IgH	igh	NN	NN	_	57	compound	_	_
57	enhancer	enhancer	NN	NN	_	41	nmod	_	_
58	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NF-microB-binding	nf-microb-binding	JJ	JJ	_	6	amod	_	_
6	site	site	NN	NN	_	7	nsubj	_	_
7	plays	play	VBZ	VBZ	_	2	ccomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	critical	critical	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IgH	igh	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	7	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	because	because	IN	IN	_	23	mark	_	_
17	mutation	mutation	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	microB	microb	NN	NN	_	22	compound	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	motif	motif	NN	NN	_	17	nmod	_	_
23	decreased	decrease	VBD	VBD	_	2	advcl	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	activity	activity	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IgH	igh	NN	NN	_	29	compound	_	_
29	enhancer	enhancer	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	B-cell	b-cell	NN	NN	_	35	compound	_	_
35	lineage	lineage	NN	NN	_	31	nmod	_	_
36	but	but	CC	CC	_	31	cc	_	_
37	not	not	RB	RB	_	40	neg	_	_
38	in	in	IN	IN	_	40	case	_	_
39	nonlymphoid	nonlymphoid	JJ	JJ	_	40	amod	_	_
40	cells	cell	NNS	NNS	_	31	conj	_	_
41	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	comparable	comparable	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	4	nmod	_	_
6	or	or	CC	CC	_	4	cc	_	_
7	even	even	RB	RB	_	8	advmod	_	_
8	stronger	stronger	JJR	JJR	_	4	conj	_	_
9	than	than	IN	IN	_	8	nmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effect	effect	NN	NN	_	4	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	mutation	mutation	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	OCTA	octa	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	combined	combined	JJ	JJ	_	4	amod	_	_
4	mutation	mutation	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	microB	microb	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	OCTA	octa	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	7	conj	_	_
11	further	further	RBR	RBR	_	12	advmod	_	_
12	reduced	reduce	VBD	VBD	_	0	root	_	_
13	enhancer	enhancer	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Interestingly	interestingly	RB	RB	_	26	advmod	_	_
2	,	,	,	,	_	26	punct	_	_
3	alteration	alteration	NN	NN	_	26	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	either	either	CC	CC	_	7	cc:preconj	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	microB	microb	NN	NN	_	3	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	E3	e3	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	7	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	70-base-pair	70-base-pair	JJ	JJ	_	14	amod	_	_
14	fragment	fragment	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	IgH	igh	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	lacks	lack	VBZ	VBZ	_	18	acl:relcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	binding	bind	VBG	VBG	_	23	amod	_	_
23	site	site	NN	NN	_	20	dobj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	OCTA	octa	NN	NN	_	23	nmod	_	_
26	abolished	abolish	VBD	VBD	_	0	root	_	_
27	enhancer	enhancer	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	lymphoid	lymphoid	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	completely	completely	RB	RB	_	26	advmod	_	_
33	.	.	.	.	_	26	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	multimer	multimer	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	microB	microb	NN	NN	_	8	compound	_	_
8	motif	motif	NN	NN	_	4	nmod	_	_
9	alone	alone	RB	RB	_	4	advmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	13	neg	_	_
12	enhancer	enhancer	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	10	punct	_	_

1	DNase	dnase	NN	NN	_	3	compound	_	_
2	footprinting	footprinting	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	corroborated	corroborate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	data	datum	NNS	NNS	_	4	dobj	_	_
8	showing	show	VBG	VBG	_	7	acl	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	a	a	DT	DT	_	12	det	_	_
11	lymphoid-specific	lymphoid-specific	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	13	nsubj	_	_
13	binds	bind	VBZ	VBZ	_	8	ccomp	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	microB	microb	NN	NN	_	18	compound	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	microB	microb	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	new	new	JJ	JJ	_	12	amod	_	_
11	crucial	crucial	JJ	JJ	_	10	dep	_	_
12	element	element	NN	NN	_	3	ccomp	_	_
13	important	important	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	lymphoid-specific	lymphoid-specific	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IgH	igh	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	but	but	CC	CC	_	12	cc	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	interaction	interaction	NN	NN	_	29	nsubj	_	_
24	with	with	IN	IN	_	27	case	_	_
25	another	another	DT	DT	_	27	det	_	_
26	enhancer	enhancer	NN	NN	_	27	compound	_	_
27	element	element	NN	NN	_	23	nmod	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	essential	essential	JJ	JJ	_	12	conj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
32	activity	activity	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Heterogeneity	heterogeneity	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	antigen	antigen	NN	NN	_	4	compound	_	_
4	molecules	molecule	NNS	NNS	_	1	nmod	_	_
5	recognized	recognize	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	anti-tax1	anti-tax1	JJ	JJ	_	9	amod	_	_
8	monoclonal	monoclonal	JJ	JJ	_	9	amod	_	_
9	antibody	antibody	NN	NN	_	5	nmod	_	_
10	Lt-4	lt-4	NN	NN	_	9	dep	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	5	nmod	_	_
14	bearing	bear	VBG	VBG	_	13	acl	_	_
15	human	human	JJ	JJ	_	20	amod	_	_
16	T	t	NN	NN	_	20	compound	_	_
17	cell	cell	NN	NN	_	20	compound	_	_
18	leukemia	leukemia	NN	NN	_	20	compound	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	type	type	NN	NN	_	14	dobj	_	_
21	I	i	CD	CD	_	20	nummod	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	related	related	JJ	JJ	_	24	amod	_	_
24	retroviruses	retrovirus	NNS	NNS	_	20	conj	_	_
25	.	.	.	.	_	1	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	4	det	_	_
3	monoclonal	monoclonal	JJ	JJ	_	4	amod	_	_
4	antibody	antibody	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	Lt-4	lt-4	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	directed	direct	VBN	VBN	_	4	acl	_	_
9	against	against	IN	IN	_	24	case	_	_
10	human	human	JJ	JJ	_	24	amod	_	_
11	T	t	NN	NN	_	24	compound	_	_
12	cell	cell	NN	NN	_	24	compound	_	_
13	leukemia	leukemia	NN	NN	_	24	compound	_	_
14	virus	virus	NN	NN	_	24	compound	_	_
15	type	type	NN	NN	_	24	compound	_	_
16	I	i	CD	CD	_	24	nummod	_	_
17	(	(	-LRB-	-LRB-	_	24	punct	_	_
18	HTLV-I	htlv-i	NN	NN	_	24	compound	_	_
19	)	)	-RRB-	-RRB-	_	24	punct	_	_
20	trans-activator	trans-activator	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	tax1	tax1	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	antigen	antigen	NN	NN	_	8	nmod	_	_
25	,	,	,	,	_	1	punct	_	_
26	we	we	PRP	PRP	_	27	nsubj	_	_
27	examined	examine	VBD	VBD	_	1	parataxis	_	_
28	the	the	DT	DT	_	29	det	_	_
29	expression	expression	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	tax1	tax1	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	related	related	JJ	JJ	_	34	amod	_	_
34	antigens	antigen	NNS	NNS	_	31	conj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	a	a	DT	DT	_	37	det	_	_
37	variety	variety	NN	NN	_	29	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	T	t	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	lines	line	NNS	NNS	_	37	nmod	_	_
42	bearing	bear	VBG	VBG	_	41	acl	_	_
43	HTLV-I	htlv-i	NN	NN	_	42	dobj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	related	related	JJ	JJ	_	46	amod	_	_
46	retroviruses	retrovirus	NNS	NNS	_	43	conj	_	_
47	,	,	,	,	_	43	punct	_	_
48	simian	simian	JJ	JJ	_	53	amod	_	_
49	T	t	NN	NN	_	53	compound	_	_
50	cell	cell	NN	NN	_	53	compound	_	_
51	leukemia	leukemia	NN	NN	_	53	compound	_	_
52	virus	virus	NN	NN	_	53	compound	_	_
53	type	type	NN	NN	_	43	appos	_	_
54	I	i	CD	CD	_	53	nummod	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	STLV-I	stlv-i	NN	NN	_	53	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	and	and	CC	CC	_	53	cc	_	_
59	HTLV-II	htlv-ii	NN	NN	_	53	conj	_	_
60	,	,	,	,	_	27	punct	_	_
61	by	by	IN	IN	_	62	case	_	_
62	immunofluorescence	immunofluorescence	NN	NN	_	27	nmod	_	_
63	and	and	CC	CC	_	62	cc	_	_
64	immunoblot	immunoblot	NN	NN	_	62	conj	_	_
65	assays	assay	NNS	NNS	_	62	dep	_	_
66	.	.	.	.	_	1	punct	_	_

1	Lt-4	lt-4	NN	NN	_	2	nsubj	_	_
2	reacted	react	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	7	case	_	_
4	all	all	DT	DT	_	7	det	_	_
5	HTLV-I-bearing	htlv-i-bearing	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	2	nmod	_	_
8	tested	test	VBN	VBN	_	7	acl	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	five	five	CD	CD	_	13	compound	_	_
11	out	out	IN	IN	_	13	advmod	_	_
12	of	of	IN	IN	_	13	advmod	_	_
13	eight	eight	CD	CD	_	16	nummod	_	_
14	simian	simian	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	7	conj	_	_
17	bearing	bear	VBG	VBG	_	16	acl	_	_
18	STLV-I	stlv-i	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	7	punct	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	7	cc	_	_
22	with	with	IN	IN	_	26	case	_	_
23	an	a	DT	DT	_	26	det	_	_
24	HTLV-II-bearing	htlv-ii-bearing	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	7	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	Lt-4	lt-4	NN	NN	_	2	nsubj	_	_
2	detected	detect	VBD	VBD	_	0	root	_	_
3	40	40	CD	CD	_	4	compound	_	_
4	kd	kd	NN	NN	_	7	amod	_	_
5	tax1	tax1	NN	NN	_	7	compound	_	_
6	antigen	antigen	NN	NN	_	7	compound	_	_
7	molecules	molecule	NNS	NNS	_	2	dobj	_	_
8	in	in	IN	IN	_	13	case	_	_
9	most	most	JJS	JJS	_	13	amod	_	_
10	HTLV-I	htlv-i	JJ	JJ	_	13	amod	_	_
11	-bearing	-bearing	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	2	nmod	_	_
14	except	except	IN	IN	_	17	case	_	_
15	one	one	CD	CD	_	17	nummod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	2	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	expressed	express	VBD	VBD	_	17	acl:relcl	_	_
20	39	39	CD	CD	_	23	nummod	_	_
21	kd	kd	NN	NN	_	23	compound	_	_
22	tax1	tax1	NN	NN	_	23	compound	_	_
23	antigen	antigen	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	STLV-I-bearing	stlv-i-bearing	JJ	JJ	_	6	amod	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	15	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	tax1-related	tax1-related	JJ	JJ	_	10	amod	_	_
9	antigen	antigen	NN	NN	_	10	compound	_	_
10	molecules	molecule	NNS	NNS	_	15	nsubj	_	_
11	detected	detect	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Lt-4	lt-4	NN	NN	_	11	nmod	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	heterogeneous	heterogeneous	JJ	JJ	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	having	have	VBG	VBG	_	15	xcomp	_	_
18	molecular	molecular	JJ	JJ	_	19	amod	_	_
19	weights	weight	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	range	range	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	36-41	36-41	CD	CD	_	25	nummod	_	_
25	kd	kd	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-fos	c-fos	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	c-myc	c-myc	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	4	conj	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	heat	heat	NN	NN	_	15	compound	_	_
15	shock	shock	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	lymphoid	lymphoid	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	heat	heat	NN	NN	_	5	compound	_	_
5	shock	shock	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	protooncogenes	protooncogene	NNS	NNS	_	8	nmod	_	_
13	c-fos	c-fos	NN	NN	_	12	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	c-jun	c-jun	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	c-myc	c-myc	NN	NN	_	13	conj	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	studied	study	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	lymphoid	lymphoid	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	Heat	heat	NN	NN	_	2	compound	_	_
2	shock	shock	NN	NN	_	3	nsubj	_	_
3	caused	cause	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	increase	increase	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	c-fos	c-fos	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	c-jun	c-jun	NN	NN	_	7	conj	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	7	dep	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	a	a	DT	DT	_	14	det	_	_
14	decrease	decrease	NN	NN	_	5	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	c-myc	c-myc	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	pre-B	pre-b	JJ	JJ	_	5	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	Hyon	hyon	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	T	t	NN	NN	_	20	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	DND-41	dnd-41	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	20	dep	_	_
31	as	as	RB	RB	_	20	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	in	in	IN	IN	_	39	case	_	_
35	freshly	freshly	RB	RB	_	36	advmod	_	_
36	isolated	isolate	VBN	VBN	_	39	amod	_	_
37	normal	normal	JJ	JJ	_	39	amod	_	_
38	human	human	JJ	JJ	_	39	amod	_	_
39	thymocytes	thymocyte	NNS	NNS	_	20	conj	_	_
40	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	changes	change	NNS	NNS	_	15	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	protooncogenes	protooncogene	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Hyon	hyon	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	were	be	VBD	VBD	_	15	aux	_	_
14	most	most	RBS	RBS	_	15	advmod	_	_
15	pronounced	pronounced	JJ	JJ	_	0	root	_	_
16	at	at	IN	IN	_	21	case	_	_
17	42	42	CD	CD	_	21	nummod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	43	43	CD	CD	_	17	conj	_	_
20	degrees	degree	NNS	NNS	_	21	compound	_	_
21	C	c	NN	NN	_	15	nmod	_	_
22	;	;	:	:	_	15	punct	_	_
23	kinetic	kinetic	JJ	JJ	_	24	amod	_	_
24	analysis	analysis	NN	NN	_	25	nsubj	_	_
25	demonstrated	demonstrate	VBD	VBD	_	15	parataxis	_	_
26	that	that	IN	IN	_	31	mark	_	_
27	the	the	DT	DT	_	28	det	_	_
28	changes	change	NNS	NNS	_	31	nsubjpass	_	_
29	could	could	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	detected	detect	VBN	VBN	_	25	ccomp	_	_
32	within	within	IN	IN	_	34	case	_	_
33	30	30	CD	CD	_	34	nummod	_	_
34	min	min	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	heat	heat	NN	NN	_	37	compound	_	_
37	shock	shock	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	Altered	altered	JJ	JJ	_	2	amod	_	_
2	transcription	transcription	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-fos	c-fos	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-myc	c-myc	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	4	conj	_	_
8	was	be	VBD	VBD	_	11	cop	_	_
9	the	the	DT	DT	_	11	det	_	_
10	primary	primary	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	heat	heat	NN	NN	_	14	compound	_	_
14	shock	shock	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Secondarily	secondarily	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	heat	heat	NN	NN	_	4	compound	_	_
4	shock	shock	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Hyon	hyon	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	stabilized	stabilize	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	c-myc	c-myc	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	level	level	NN	NN	_	8	dobj	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	increasing	increase	VBG	VBG	_	8	advcl	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	half-life	half-life	NN	NN	_	14	dobj	_	_
17	from	from	IN	IN	_	21	case	_	_
18	24	24	CD	CD	_	20	compound	_	_
19	to	to	TO	TO	_	20	dep	_	_
20	45	45	CD	CD	_	21	nummod	_	_
21	min	min	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	overall	overall	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	heat	heat	NN	NN	_	6	compound	_	_
6	shock	shock	NN	NN	_	3	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	c-myc	c-myc	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	level	level	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	however	however	RB	RB	_	17	advmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	was	be	VBD	VBD	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	marked	marked	JJ	JJ	_	17	amod	_	_
17	inhibition	inhibition	NN	NN	_	0	root	_	_
18	of	of	IN	IN	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	transcription	transcription	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	transcription	transcription	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	protooncogenes	protooncogene	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	14	case	_	_
13	heat	heat	NN	NN	_	14	compound	_	_
14	shock	shock	NN	NN	_	11	nmod	_	_
15	indicating	indicate	VBG	VBG	_	11	xcomp	_	_
16	a	a	DT	DT	_	17	det	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	protooncogenes	protooncogene	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	stress	stress	NN	NN	_	24	compound	_	_
24	response	response	NN	NN	_	15	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	lymphoid	lymphoid	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	0	root	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	recognizes	recognize	VBZ	VBZ	_	4	acl:relcl	_	_
7	a	a	DT	DT	_	9	det	_	_
8	palindromic	palindromic	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	negative	negative	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	element	element	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	human	human	JJ	JJ	_	22	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
19	virus	virus	NN	NN	_	22	compound	_	_
20	long	long	JJ	JJ	_	22	amod	_	_
21	terminal	terminal	JJ	JJ	_	22	amod	_	_
22	repeat	repeat	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	major	major	JJ	JJ	_	4	amod	_	_
3	protein-binding	protein-binding	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	22	nsubjpass	_	_
5	within	within	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	negative	negative	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	19	case	_	_
11	the	the	DT	DT	_	19	det	_	_
12	human	human	JJ	JJ	_	19	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	19	compound	_	_
14	virus	virus	NN	NN	_	19	compound	_	_
15	type	type	NN	NN	_	19	compound	_	_
16	1	1	CD	CD	_	19	nummod	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	terminal	terminal	JJ	JJ	_	19	amod	_	_
19	repeat	repeat	NN	NN	_	9	nmod	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	identified	identify	VBN	VBN	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	One	one	CD	CD	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	site	site	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	palindromic	palindromic	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	6	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	homology	homology	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	steroid/thyroid	steroid/thyroid	NN	NN	_	16	compound	_	_
14	hormone	hormone	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	elements	element	NNS	NNS	_	11	nmod	_	_
17	but	but	CC	CC	_	6	cc	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	distinct	distinct	JJ	JJ	_	6	conj	_	_
20	from	from	IN	IN	_	24	case	_	_
21	previously	previously	RB	RB	_	22	advmod	_	_
22	described	describe	VBN	VBN	_	24	amod	_	_
23	binding	bind	VBG	VBG	_	24	amod	_	_
24	sites	site	NNS	NNS	_	19	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	class	class	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	recognized	recognize	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	palindromic	palindromic	JJ	JJ	_	8	amod	_	_
8	sequence	sequence	NN	NN	_	5	dobj	_	_
9	within	within	IN	IN	_	11	case	_	_
10	site	site	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	bound	bind	VBD	VBD	_	5	conj	_	_
15	estrogen-	estrogen-	NN	NN	_	14	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	thyroid	thyroid	NN	NN	_	18	compound	_	_
18	hormone-response	hormone-response	NN	NN	_	15	conj	_	_
19	elements	element	NNS	NNS	_	15	dep	_	_
20	with	with	IN	IN	_	22	case	_	_
21	lower	lower	JJR	JJR	_	22	amod	_	_
22	affinity	affinity	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	7-base-pair	7-base-pair	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	15	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	site	site	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	palindrome	palindrome	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	destroyed	destroy	VBD	VBD	_	3	acl:relcl	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	3	punct	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	increased	increase	VBN	VBN	_	18	amod	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	from	from	IN	IN	_	28	case	_	_
20	the	the	DT	DT	_	28	det	_	_
21	human	human	JJ	JJ	_	28	amod	_	_
22	immunodeficiency	immunodeficiency	NN	NN	_	28	compound	_	_
23	virus	virus	NN	NN	_	28	compound	_	_
24	type	type	NN	NN	_	28	compound	_	_
25	1	1	CD	CD	_	28	nummod	_	_
26	long	long	JJ	JJ	_	28	amod	_	_
27	terminal	terminal	JJ	JJ	_	28	amod	_	_
28	repeat	repeat	NN	NN	_	18	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	4	amod	_	_
2	virus	virus	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	antigen	antigen	NN	NN	_	6	nsubj	_	_
5	2	2	CD	CD	_	4	nummod	_	_
6	transactivates	transactivate	VBZ	VBZ	_	0	root	_	_
7	latent	latent	JJ	JJ	_	9	amod	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	LMP1	lmp1	NN	NN	_	9	dep	_	_
11	.	.	.	.	_	6	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	lines	line	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	evidence	evidence	NN	NN	_	2	nmod	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	compatible	compatible	JJ	JJ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	hypothesis	hypothesis	NN	NN	_	6	nmod	_	_
10	that	that	IN	IN	_	28	mark	_	_
11	Epstein-Barr	epstein-barr	JJ	JJ	_	17	amod	_	_
12	virus	virus	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	EBV	ebv	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	antigen	antigen	NN	NN	_	28	nsubj	_	_
18	2	2	CD	CD	_	17	nummod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	EBNA-2	ebna-2	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	or	or	CC	CC	_	17	cc	_	_
23	leader	leader	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	17	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	EBNA-LP	ebna-lp	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	affects	affect	VBZ	VBZ	_	9	ccomp	_	_
29	expression	expression	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	36	case	_	_
31	the	the	DT	DT	_	36	det	_	_
32	EBV	ebv	NN	NN	_	36	compound	_	_
33	latent	latent	JJ	JJ	_	36	amod	_	_
34	infection	infection	NN	NN	_	36	compound	_	_
35	membrane	membrane	NN	NN	_	36	compound	_	_
36	protein	protein	NN	NN	_	29	nmod	_	_
37	LMP1	lmp1	NN	NN	_	36	dep	_	_
38	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	following	following	NN	NN	_	3	dobj	_	_
6	.	.	.	.	_	3	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	i	i	LS	LS	_	22	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Acute	acute	JJ	JJ	_	5	amod	_	_
5	transfection	transfection	NN	NN	_	22	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	expression	expression	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	EBNA-2	ebna-2	NN	NN	_	5	nmod	_	_
10	under	under	IN	IN	_	11	case	_	_
11	control	control	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	simian	simian	JJ	JJ	_	14	amod	_	_
14	virus	virus	NN	NN	_	11	nmod	_	_
15	40	40	CD	CD	_	14	nummod	_	_
16	or	or	CC	CC	_	14	cc	_	_
17	Moloney	moloney	NN	NN	_	21	compound	_	_
18	murine	murine	JJ	JJ	_	21	amod	_	_
19	leukemia	leukemia	NN	NN	_	21	compound	_	_
20	virus	virus	NN	NN	_	21	compound	_	_
21	promoters	promoter	NNS	NNS	_	14	conj	_	_
22	resulted	result	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	26	case	_	_
24	increased	increase	VBN	VBN	_	26	amod	_	_
25	LMP1	lmp1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	P3HR-1-infected	p3hr-1-infected	JJ	JJ	_	32	amod	_	_
29	Burkitt	burkitt	NN	NN	_	32	nmod:poss	_	_
30	's	's	POS	POS	_	32	case	_	_
31	lymphoma	lymphoma	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	26	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	the	the	DT	DT	_	35	dep	_	_
35	P3HR-1	p3hr-1	NN	NN	_	32	conj	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	Daudi	daudi	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	35	conj	_	_
40	.	.	.	.	_	22	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ii	ii	LS	LS	_	10	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Transfection	transfection	NN	NN	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	expression	expression	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	EBNA-LP	ebna-lp	NN	NN	_	4	nmod	_	_
9	alone	alone	RB	RB	_	4	advmod	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	effect	effect	NN	NN	_	10	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	LMP1	lmp1	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	act	act	VB	VB	_	10	conj	_	_
20	synergistically	synergistically	RB	RB	_	19	advmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	EBNA-2	ebna-2	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	affect	affect	VB	VB	_	19	xcomp	_	_
25	LMP1	lmp1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	iii	iii	LS	LS	_	12	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	LMP1	lmp1	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	12	nsubjpass	_	_
6	in	in	IN	IN	_	7	case	_	_
7	Daudi	daudi	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	P3HR-1-infected	p3hr-1-infected	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	controlled	control	VBN	VBN	_	0	root	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	level	level	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	EBNA-2	ebna-2	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	24	nsubj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	Daudi	daudi	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	increased	increase	VBD	VBD	_	12	conj	_	_
25	LMP1	lmp1	NN	NN	_	26	compound	_	_
26	mRNA	mrna	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	12	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	iv	iv	LS	LS	_	9	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	No	no	DT	DT	_	7	neg	_	_
5	other	other	JJ	JJ	_	7	amod	_	_
6	EBV	ebv	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	required	require	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	EBNA-2	ebna-2	NN	NN	_	12	compound	_	_
12	transactivation	transactivation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	LMP1	lmp1	NN	NN	_	12	nmod	_	_
15	since	since	IN	IN	_	27	mark	_	_
16	cotransfection	cotransfection	NN	NN	_	27	nsubj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	recombinant	recombinant	JJ	JJ	_	21	amod	_	_
19	EBNA-2	ebna-2	NN	NN	_	21	compound	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	vectors	vector	NNS	NNS	_	16	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	genomic	genomic	JJ	JJ	_	26	amod	_	_
24	LMP1	lmp1	NN	NN	_	26	compound	_	_
25	DNA	dna	NN	NN	_	26	compound	_	_
26	fragments	fragment	NNS	NNS	_	21	conj	_	_
27	enhanced	enhance	VBD	VBD	_	9	advcl	_	_
28	LMP1	lmp1	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	EBV-negative	ebv-negative	JJ	JJ	_	35	amod	_	_
33	B-lymphoma	b-lymphoma	NN	NN	_	35	compound	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	27	nmod	_	_
36	BJAB	bjab	NN	NN	_	35	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	Louckes	louckes	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	BL30	bl30	NN	NN	_	36	conj	_	_
42	.	.	.	.	_	9	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	v	v	LS	LS	_	8	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	An	a	DT	DT	_	6	det	_	_
5	EBNA-2-responsive	ebna-2-responsive	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	within	within	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	-512	-512	CD	CD	_	15	nummod	_	_
12	to	to	TO	TO	_	15	dep	_	_
13	+40	+40	CD	CD	_	15	nummod	_	_
14	LMP1	lmp1	NN	NN	_	15	compound	_	_
15	DNA	dna	NN	NN	_	8	nmod	_	_
16	since	since	IN	IN	_	27	mark	_	_
17	this	this	DT	DT	_	18	det	_	_
18	DNA	dna	NN	NN	_	27	nsubjpass	_	_
19	linked	link	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	chloramphenicol	chloramphenicol	NN	NN	_	25	compound	_	_
23	acetyltransferase	acetyltransferase	NN	NN	_	25	compound	_	_
24	reporter	reporter	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	19	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	transactivated	transactivate	VBN	VBN	_	8	advcl	_	_
28	by	by	IN	IN	_	29	case	_	_
29	cotransfection	cotransfection	NN	NN	_	27	nmod	_	_
30	with	with	IN	IN	_	34	case	_	_
31	an	a	DT	DT	_	34	det	_	_
32	EBNA-2	ebna-2	NN	NN	_	34	compound	_	_
33	expression	expression	NN	NN	_	34	compound	_	_
34	vector	vector	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	vi	vi	LS	LS	_	9	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	The	the	DT	DT	_	6	det	_	_
5	EBV	ebv	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	9	nsubj	_	_
7	2	2	CD	CD	_	6	nummod	_	_
8	EBNA-2	ebna-2	NN	NN	_	6	dep	_	_
9	transactivated	transactivate	VBD	VBD	_	0	root	_	_
10	LMP1	lmp1	NN	NN	_	9	dobj	_	_
11	as	as	RB	RB	_	10	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	the	the	DT	DT	_	18	det	_	_
15	EBV	ebv	NN	NN	_	18	compound	_	_
16	type	type	NN	NN	_	18	compound	_	_
17	1	1	CD	CD	_	18	nummod	_	_
18	EBNA-2	ebna-2	NN	NN	_	10	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	vii	vii	LS	LS	_	17	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Two	two	CD	CD	_	5	nummod	_	_
5	deletions	deletion	NNS	NNS	_	17	nsubj	_	_
6	within	within	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	EBNA-2	ebna-2	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	rendered	render	VBD	VBD	_	5	acl:relcl	_	_
12	EBV	ebv	NN	NN	_	13	compound	_	_
13	transformation	transformation	NN	NN	_	14	nsubj	_	_
14	incompetent	incompetent	JJ	JJ	_	11	xcomp	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	transactivate	transactivate	VB	VB	_	0	root	_	_
18	LMP1	lmp1	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	17	punct	_	_
20	whereas	whereas	IN	IN	_	27	mark	_	_
21	a	a	DT	DT	_	25	det	_	_
22	transformation-competent	transformation-competent	JJ	JJ	_	25	amod	_	_
23	EBNA-2	ebna-2	NN	NN	_	25	compound	_	_
24	deletion	deletion	NN	NN	_	25	compound	_	_
25	mutant	mutant	NN	NN	_	27	nsubj	_	_
26	did	do	VBD	VBD	_	27	aux	_	_
27	transactivate	transactivate	VB	VB	_	17	advcl	_	_
28	LMP1	lmp1	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	17	punct	_	_

1	LMP1	lmp1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potent	potent	JJ	JJ	_	5	amod	_	_
5	effector	effector	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	B-lymphocyte	b-lymphocyte	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	act	act	VB	VB	_	5	conj	_	_
12	synergistically	synergistically	RB	RB	_	11	advmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	EBNA-2	ebna-2	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	11	xcomp	_	_
17	cellular	cellular	JJ	JJ	_	20	amod	_	_
18	CD23	cd23	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	EBNA-2	ebna-2	NN	NN	_	4	compound	_	_
4	transactivation	transactivation	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	LMP1	lmp1	NN	NN	_	4	nmod	_	_
7	amplifies	amplify	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	biological	biological	JJ	JJ	_	10	amod	_	_
10	impact	impact	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	EBNA-2	ebna-2	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	underscores	underscore	VBZ	VBZ	_	7	conj	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	central	central	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	EBV-induced	ebv-induced	JJ	JJ	_	21	amod	_	_
20	growth	growth	NN	NN	_	21	compound	_	_
21	transformation	transformation	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Steroid	steroid	NN	NN	_	3	compound	_	_
2	dose	dose	NN	NN	_	3	compound	_	_
3	sparing	sparing	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	pharmacodynamic	pharmacodynamic	JJ	JJ	_	6	amod	_	_
6	responses	response	NNS	NNS	_	3	dep	_	_
7	to	to	TO	TO	_	8	case	_	_
8	single	single	JJ	JJ	_	6	nmod	_	_
9	versus	versus	CC	CC	_	8	cc	_	_
10	divided	divided	JJ	JJ	_	8	conj	_	_
11	doses	dose	NNS	NNS	_	8	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	methylprednisolone	methylprednisolone	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	man	man	NN	NN	_	6	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
2	drug	drug	NN	NN	_	3	compound	_	_
3	interactions	interaction	NNS	NNS	_	13	nsubj	_	_
4	affecting	affect	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	metabolism	metabolism	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	methylprednisolone	methylprednisolone	NN	NN	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MP	mp	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	produce	produce	VB	VB	_	0	root	_	_
14	either	either	CC	CC	_	16	cc:preconj	_	_
15	steroid	steroid	NN	NN	_	16	compound	_	_
16	sparing	sparing	NN	NN	_	13	dobj	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	adverse	adverse	JJ	JJ	_	19	amod	_	_
19	effects	effect	NNS	NNS	_	16	conj	_	_
20	partly	partly	RB	RB	_	22	advmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	increasing	increase	VBG	VBG	_	16	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	exposure	exposure	NN	NN	_	25	compound	_	_
25	time	time	NN	NN	_	22	dobj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	steroid	steroid	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenomenon	phenomenon	NN	NN	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	mimicked	mimic	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	administering	administer	VBG	VBG	_	5	advcl	_	_
8	MP	mp	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	divided	divided	JJ	JJ	_	11	amod	_	_
11	doses	dose	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	types	type	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	responses	response	NNS	NNS	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	compared	compare	VBN	VBN	_	0	root	_	_
7	after	after	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	single	single	JJ	JJ	_	11	amod	_	_
10	MP	mp	NN	NN	_	11	compound	_	_
11	dose	dose	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	40	40	CD	CD	_	14	compound	_	_
14	mg	mg	NN	NN	_	15	nummod	_	_
15	bolus	bolus	NN	NN	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	divided	divided	JJ	JJ	_	20	amod	_	_
20	regimen	regimen	NN	NN	_	11	conj	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	20	20	CD	CD	_	23	compound	_	_
23	mg	mg	NN	NN	_	24	nummod	_	_
24	bolus	bolus	NN	NN	_	20	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	a	a	DT	DT	_	29	det	_	_
27	5	5	CD	CD	_	28	compound	_	_
28	mg	mg	NN	NN	_	29	nummod	_	_
29	bolus	bolus	NN	NN	_	24	conj	_	_
30	8	8	CD	CD	_	31	nummod	_	_
31	hours	hour	NNS	NNS	_	32	nmod:npmod	_	_
32	later	later	RB	RB	_	29	advmod	_	_
33	)	)	-RRB-	-RRB-	_	24	punct	_	_
34	in	in	IN	IN	_	38	case	_	_
35	six	six	CD	CD	_	38	nummod	_	_
36	healthy	healthy	JJ	JJ	_	38	amod	_	_
37	male	male	JJ	JJ	_	36	dep	_	_
38	volunteers	volunteer	NNS	NNS	_	6	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	suppression	suppression	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	basophils	basophil	NNS	NNS	_	2	nmod	_	_
5	measured	measure	VBN	VBN	_	2	acl	_	_
6	as	as	IN	IN	_	9	case	_	_
7	whole	whole	JJ	JJ	_	9	amod	_	_
8	blood	blood	NN	NN	_	9	compound	_	_
9	histamine	histamine	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	plasma	plasma	NN	NN	_	13	compound	_	_
12	cortisol	cortisol	NN	NN	_	13	compound	_	_
13	concentrations	concentration	NNS	NNS	_	9	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	assessed	assess	VBN	VBN	_	0	root	_	_
16	during	during	IN	IN	_	18	case	_	_
17	32	32	CD	CD	_	18	nummod	_	_
18	hours	hour	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	37.5	37.5	CD	CD	_	3	compound	_	_
3	%	%	NN	NN	_	4	amod	_	_
4	reduction	reduction	NN	NN	_	7	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	dose	dose	NN	NN	_	4	nmod	_	_
7	produced	produce	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	15	det	_	_
9	23	23	CD	CD	_	10	compound	_	_
10	%	%	NN	NN	_	15	amod	_	_
11	overall	overall	RB	RB	_	15	advmod	_	_
12	decreased	decrease	VBN	VBN	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	histamine	histamine	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	7	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	pharmacodynamic	pharmacodynamic	JJ	JJ	_	3	amod	_	_
3	model	model	NN	NN	_	14	nsubj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	basophil	basophil	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	distribution	distribution	NN	NN	_	3	nmod	_	_
8	to	to	TO	TO	_	13	nmod	_	_
9	and	and	CC	CC	_	13	cc	_	_
10	from	from	IN	IN	_	13	conj	_	_
11	an	a	DT	DT	_	13	det	_	_
12	extravascular	extravascular	JJ	JJ	_	13	amod	_	_
13	compartment	compartment	NN	NN	_	7	nmod	_	_
14	describes	describe	VBZ	VBZ	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	effects	effect	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	MP	mp	NN	NN	_	16	nmod	_	_
19	after	after	IN	IN	_	21	case	_	_
20	both	both	DT	DT	_	21	det	_	_
21	regimens	regimen	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	slower	slower	JJR	JJR	_	4	amod	_	_
3	initial	initial	JJ	JJ	_	2	dep	_	_
4	decline	decline	NN	NN	_	14	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	histamine	histamine	NN	NN	_	4	nmod	_	_
8	after	after	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	divided	divided	JJ	JJ	_	11	amod	_	_
11	regimen	regimen	NNS	NNS	_	4	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	related	related	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	incomplete	incomplete	JJ	JJ	_	17	amod	_	_
17	suppression	suppression	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	basophil	basophil	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	return	return	NN	NN	_	17	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	blood	blood	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	50	50	CD	CD	_	3	compound	_	_
3	%	%	NN	NN	_	5	amod	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	concentrations	concentration	NNS	NNS	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	MP	mp	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	about	about	RB	RB	_	10	advmod	_	_
10	5	5	CD	CD	_	11	nummod	_	_
11	ng/ml	ng/ml	NN	NN	_	7	nmod	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	similar	similar	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	16	case	_	_
15	both	both	DT	DT	_	16	det	_	_
16	regimens	regimen	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	decline	decline	NN	NN	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	return	return	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cortisol	cortisol	NN	NN	_	7	compound	_	_
7	concentrations	concentration	NNS	NNS	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	between	between	IN	IN	_	12	case	_	_
11	MP	mp	NN	NN	_	12	compound	_	_
12	treatments	treatment	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	suppression	suppression	NN	NN	_	12	nmod	_	_
15	continuing	continue	VBG	VBG	_	14	acl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	24	24	CD	CD	_	18	nummod	_	_
18	hours	hour	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	50	50	CD	CD	_	3	compound	_	_
3	%	%	NN	NN	_	5	amod	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	concentrations	concentration	NNS	NNS	_	15	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	MP	mp	NN	NN	_	8	compound	_	_
8	values	value	NNS	NNS	_	5	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	adrenal	adrenal	JJ	JJ	_	11	amod	_	_
11	suppression	suppression	NN	NN	_	5	nmod	_	_
12	were	be	VBD	VBD	_	15	cop	_	_
13	about	about	RB	RB	_	14	advmod	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	ng/ml	ng/ml	NN	NN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Pharmacodynamic	pharmacodynamic	JJ	JJ	_	2	amod	_	_
2	modeling	modeling	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	useful	useful	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	quantitating	quantitate	VBG	VBG	_	4	advcl	_	_
7	corticosteroid	corticosteroid	NN	NN	_	8	compound	_	_
8	responses	response	NNS	NNS	_	6	dobj	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	generally	generally	RB	RB	_	11	advmod	_	_
11	predicted	predict	VBD	VBD	_	4	conj	_	_
12	the	the	DT	DT	_	15	det	_	_
13	``	``	``	``	_	15	punct	_	_
14	dose-sparing	dose-sparing	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	11	dobj	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	achieved	achieve	VBN	VBN	_	15	acl:relcl	_	_
19	by	by	IN	IN	_	20	mark	_	_
20	prolonging	prolong	VBG	VBG	_	18	advcl	_	_
21	MP	mp	NN	NN	_	23	compound	_	_
22	plasma	plasma	NN	NN	_	23	compound	_	_
23	concentrations	concentration	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	supports	support	VBZ	VBZ	_	0	root	_	_
4	previous	previous	JJ	JJ	_	6	amod	_	_
5	clinical	clinical	JJ	JJ	_	4	dep	_	_
6	observations	observation	NNS	NNS	_	3	dobj	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	patients	patient	NNS	NNS	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	require	require	VB	VB	_	6	ccomp	_	_
11	morning	morning	NN	NN	_	14	compound	_	_
12	through	through	IN	IN	_	13	case	_	_
13	evening	evening	NN	NN	_	11	nmod	_	_
14	exposure	exposure	NN	NN	_	10	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	MP	mp	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	optimize	optimize	VB	VB	_	10	xcomp	_	_
19	efficacy	efficacy	NN	NN	_	18	dobj	_	_
20	while	while	IN	IN	_	25	mark	_	_
21	adrenal	adrenal	JJ	JJ	_	22	amod	_	_
22	suppression	suppression	NN	NN	_	25	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	25	aux	_	_
24	being	be	VBG	VBG	_	25	auxpass	_	_
25	minimized	minimize	VBN	VBN	_	18	advcl	_	_
26	.	.	.	.	_	3	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	cyclic	cyclic	JJ	JJ	_	6	amod	_	_
4	AMP-dependent	amp-dependent	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	kinases	kinase	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	signal	signal	NN	NN	_	11	compound	_	_
10	transduction	transduction	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	1	nmod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	interleukin-1	interleukin-1	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Expression	expression	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	highly	highly	RB	RB	_	5	advmod	_	_
5	specific	specific	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	1	nmod	_	_
8	for	for	IN	IN	_	12	case	_	_
9	cyclic	cyclic	JJ	JJ	_	12	amod	_	_
10	AMP-dependent	amp-dependent	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	kinases	kinase	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	19	case	_	_
14	interleukin-1	interleukin-1	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	IL-1	il-1	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	-responsive	-responsive	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	blocked	block	VBD	VBD	_	0	root	_	_
21	IL-1-induced	il-1-induced	JJ	JJ	_	22	amod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	20	dobj	_	_
24	that	that	WDT	WDT	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	driven	drive	VBN	VBN	_	23	acl:relcl	_	_
27	by	by	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	kappa	kappa	NN	NN	_	31	compound	_	_
30	immunoglobulin	immunoglobulin	NN	NN	_	31	compound	_	_
31	enhancer	enhancer	NN	NN	_	26	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	39	det	_	_
34	human	human	JJ	JJ	_	39	amod	_	_
35	immunodeficiency	immunodeficiency	NN	NN	_	39	compound	_	_
36	virus	virus	NN	NN	_	39	compound	_	_
37	long	long	JJ	JJ	_	39	amod	_	_
38	terminal	terminal	JJ	JJ	_	39	amod	_	_
39	repeat	repeat	NN	NN	_	31	conj	_	_
40	.	.	.	.	_	20	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibitor	inhibitor	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	affect	affect	VB	VB	_	0	root	_	_
6	protein	protein	NN	NN	_	8	nmod:npmod	_	_
7	kinase	kinase	NN	NN	_	8	nmod:npmod	_	_
8	C-mediated	c-mediated	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	5	dobj	_	_
11	,	,	,	,	_	5	punct	_	_
12	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	cyclic	cyclic	JJ	JJ	_	17	amod	_	_
15	AMP-dependent	amp-dependent	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	kinases	kinase	NNS	NNS	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	involved	involve	VBN	VBN	_	12	ccomp	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	signal	signal	NN	NN	_	24	compound	_	_
23	transduction	transduction	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	19	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	IL-1	il-1	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	number	number	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	responsive	responsive	JJ	JJ	_	33	amod	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	types	type	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Protein	protein	NN	NN	_	4	compound	_	_
2	kinase	kinase	NN	NN	_	4	compound	_	_
3	inhibitor	inhibitor	NN	NN	_	4	compound	_	_
4	H-7	h-7	NN	NN	_	5	nsubj	_	_
5	blocks	block	VBZ	VBZ	_	0	root	_	_
6	accumulation	accumulation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	unspliced	unspliced	JJ	JJ	_	9	amod	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	T-cell	t-cell	NN	NN	_	15	compound	_	_
13	leukemia	leukemia	NN	NN	_	15	compound	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	type	type	NN	NN	_	9	nmod	_	_
16	I	i	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HTLV-I	htlv-i	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	5	punct	_	_

1	Rex	rex	NN	NN	_	18	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	post-transcriptional	post-transcriptional	JJ	JJ	_	5	amod	_	_
5	regulator	regulator	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	11	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	T-cell	t-cell	NN	NN	_	11	compound	_	_
9	leukemia	leukemia	NN	NN	_	11	compound	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	5	nmod	_	_
12	I	i	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HTLV-I	htlv-i	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	1	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	known	know	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	induce	induce	VB	VB	_	18	xcomp	_	_
21	accumulation	accumulation	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	unspliced	unspliced	JJ	JJ	_	27	amod	_	_
25	viral	viral	JJ	JJ	_	27	amod	_	_
26	gag-pol	gag-pol	NN	NN	_	27	compound	_	_
27	mRNA	mrna	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	Rex	rex	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	phosphoprotein	phosphoprotein	NN	NN	_	0	root	_	_
5	found	find	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	nucleolus	nucleolus	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
12	function	function	NN	NN	_	15	nsubjpass	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	regulated	regulate	VBN	VBN	_	4	acl:relcl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	localization	localization	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	phosphorylation	phosphorylation	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	Rex	rex	NN	NN	_	10	compound	_	_
10	function	function	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	using	use	VBG	VBG	_	3	advcl	_	_
13	a	a	DT	DT	_	16	det	_	_
14	protein	protein	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	inhibitor	inhibitor	NN	NN	_	12	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	H-7	h-7	NN	NN	_	16	appos	_	_
19	-LSB-	-lsb-	-LRB-	-LRB-	_	20	punct	_	_
20	1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine	1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine	NN	NN	_	18	appos	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	3	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	an	a	DT	DT	_	8	det	_	_
4	HTLV-I	htlv-i	NN	NN	_	8	compound	_	_
5	infected	infected	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	1	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	H-7	h-7	NN	NN	_	1	nmod	_	_
11	blocked	block	VBD	VBD	_	0	root	_	_
12	specifically	specifically	RB	RB	_	11	advmod	_	_
13	accumulation	accumulation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	unspliced	unspliced	JJ	JJ	_	18	amod	_	_
17	gag-pol	gag-pol	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	11	punct	_	_
20	resulting	result	VBG	VBG	_	11	advcl	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	decreased	decrease	VBN	VBN	_	26	amod	_	_
24	Gag	gag	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	synthesis	synthesis	NN	NN	_	20	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	corresponds	correspond	VBZ	VBZ	_	26	acl:relcl	_	_
29	with	with	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	decreased	decrease	VBN	VBN	_	34	amod	_	_
32	in	in	FW	FW	_	34	amod	_	_
33	vivo	vivo	FW	FW	_	32	dep	_	_
34	phosphorylation	phosphorylation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	Rex	rex	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	viral	viral	JJ	JJ	_	12	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cellular	cellular	JJ	JJ	_	5	conj	_	_
8	products	product	NNS	NNS	_	5	dep	_	_
9	have	have	VBP	VBP	_	12	aux	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	influenced	influence	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	level	level	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	H-7	h-7	NN	NN	_	15	nmod	_	_
18	used	use	VBN	VBN	_	17	acl	_	_
19	.	.	.	.	_	12	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	phosphorylation	phosphorylation	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Rex	rex	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	viral	viral	JJ	JJ	_	13	amod	_	_
12	RNA	rna	NN	NN	_	13	compound	_	_
13	partition	partition	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	HTLV-I	htlv-i	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Increased	increase	VBN	VBN	_	3	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	responsiveness	responsiveness	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	CD4+	cd4+	JJ	JJ	_	8	amod	_	_
6	T-cell	t-cell	NN	NN	_	8	compound	_	_
7	clonal	clonal	JJ	JJ	_	8	amod	_	_
8	lines	line	NNS	NNS	_	3	nmod	_	_
9	grown	grow	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	serum-free	serum-free	JJ	JJ	_	12	amod	_	_
12	media	media	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	CEM-C7	cem-c7	NN	NN	_	40	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	leukemic	leukemic	JJ	JJ	_	9	amod	_	_
6	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
7	T-lymphocyte	t-lymphocyte	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	1	appos	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	three	three	CD	CD	_	1	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	subclones	subclone	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	CEM-4R4	cem-4r4	NN	NN	_	11	appos	_	_
17	,	,	,	,	_	16	punct	_	_
18	CEM-3R43	cem-3r43	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	ICR-27	icr-27	NN	NN	_	16	conj	_	_
22	,	,	,	,	_	1	punct	_	_
23	previously	previously	RB	RB	_	24	advmod	_	_
24	cultured	culture	VBN	VBN	_	1	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	medium	medium	NN	NN	_	24	nmod	_	_
28	supplemented	supplement	VBN	VBN	_	27	acl	_	_
29	with	with	IN	IN	_	36	case	_	_
30	5	5	CD	CD	_	32	compound	_	_
31	to	to	TO	TO	_	32	dep	_	_
32	10	10	CD	CD	_	33	dep	_	_
33	%	%	NN	NN	_	36	dep	_	_
34	fetal	fetal	JJ	JJ	_	36	amod	_	_
35	bovine	bovine	JJ	JJ	_	36	amod	_	_
36	serum	serum	NN	NN	_	28	nmod	_	_
37	,	,	,	,	_	1	punct	_	_
38	have	have	VBP	VBP	_	40	aux	_	_
39	been	be	VBN	VBN	_	40	auxpass	_	_
40	adapted	adapt	VBN	VBN	_	0	root	_	_
41	to	to	TO	TO	_	43	case	_	_
42	serum-free	serum-free	JJ	JJ	_	43	amod	_	_
43	media	media	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	40	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	best	best	JJS	JJS	_	3	amod	_	_
3	medium	medium	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	those	those	DT	DT	_	3	nmod	_	_
6	tested	test	VBN	VBN	_	5	acl	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	RPMI	rpmi	NN	NN	_	0	root	_	_
9	1640	1640	CD	CD	_	8	nummod	_	_
10	supplemented	supplement	VBN	VBN	_	8	acl	_	_
11	with	with	IN	IN	_	15	case	_	_
12	5	5	CD	CD	_	13	compound	_	_
13	micrograms/ml	micrograms/ml	NNS	NNS	_	15	amod	_	_
14	each	each	DT	DT	_	15	det	_	_
15	transferrin	transferrin	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	insulin	insulin	NN	NN	_	15	conj	_	_
18	+	+	CC	CC	_	15	cc	_	_
19	5	5	CD	CD	_	20	compound	_	_
20	ng/ml	ng/ml	NN	NN	_	22	amod	_	_
21	sodium	sodium	NN	NN	_	22	compound	_	_
22	selenite	selenite	NN	NN	_	15	conj	_	_
23	+/-	+/-	CC	CC	_	15	cc	_	_
24	0.1	0.1	CD	CD	_	25	compound	_	_
25	%	%	NN	NN	_	28	amod	_	_
26	bovine	bovine	JJ	JJ	_	28	amod	_	_
27	serum	serum	NN	NN	_	28	compound	_	_
28	albumin	albumin	NN	NN	_	15	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	While	while	IN	IN	_	2	mark	_	_
2	growing	grow	VBG	VBG	_	16	advcl	_	_
3	either	either	CC	CC	_	7	cc:preconj	_	_
4	with	with	IN	IN	_	7	nmod	_	_
5	or	or	CC	CC	_	7	cc	_	_
6	without	without	IN	IN	_	7	conj	_	_
7	albumin	albumin	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	clonal	clonal	JJ	JJ	_	12	amod	_	_
12	lines	line	NNS	NNS	_	16	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	CEM	cem	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	displayed	display	VBD	VBD	_	0	root	_	_
17	growth	growth	NN	NN	_	16	dobj	_	_
18	similar	similar	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	serum-supplemented	serum-supplemented	JJ	JJ	_	21	amod	_	_
21	cultures	culture	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	proliferation	proliferation	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CEM-C7	cem-c7	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	cultured	culture	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	both	both	DT	DT	_	10	det	_	_
9	serum-free	serum-free	JJ	JJ	_	10	amod	_	_
10	media	media	NNS	NNS	_	6	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	aux	_	_
13	sustained	sustained	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	16	case	_	_
15	3	3	CD	CD	_	16	nummod	_	_
16	mo.	mo.	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	culture	culture	NN	NN	_	20	compound	_	_
19	doubling	double	VBG	VBG	_	20	amod	_	_
20	times	time	NNS	NNS	_	13	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	about	about	RB	RB	_	23	advmod	_	_
23	25	25	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	20	nmod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	serum-supplemented	serum-supplemented	JJ	JJ	_	20	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	serum-free	serum-free	JJ	JJ	_	27	conj	_	_
30	cultures	culture	NNS	NNS	_	27	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	viability	viability	NN	NN	_	13	dep	_	_
33	greater	greater	JJR	JJR	_	32	amod	_	_
34	than	than	IN	IN	_	33	nmod	_	_
35	or	or	CC	CC	_	33	cc	_	_
36	equal	equal	JJ	JJ	_	33	conj	_	_
37	to	to	TO	TO	_	36	nmod	_	_
38	90	90	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	33	dep	_	_
40	)	)	-RRB-	-RRB-	_	32	punct	_	_
41	.	.	.	.	_	13	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	morphology	morphology	NN	NN	_	3	nsubj	_	_
3	remained	remain	VBD	VBD	_	0	root	_	_
4	essentially	essentially	RB	RB	_	6	advmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	same	same	JJ	JJ	_	3	xcomp	_	_
7	in	in	IN	IN	_	8	case	_	_
8	serum-free	serum-free	JJ	JJ	_	3	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	serum	serum	NN	NN	_	11	dep	_	_
11	containing	containing	NN	NN	_	8	conj	_	_
12	media	media	NNS	NNS	_	8	dep	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CD4	cd4	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	marker	marker	NN	NN	_	4	appos	_	_
8	for	for	IN	IN	_	11	case	_	_
9	T-derived	t-derived	JJ	JJ	_	11	amod	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	was	be	VBD	VBD	_	16	cop	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	different	different	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	serum-free	serum-free	JJ	JJ	_	19	amod	_	_
19	medium	medium	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	grown	grow	VBN	VBN	_	9	advcl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	serum-free	serum-free	JJ	JJ	_	5	amod	_	_
5	medium	medium	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	CEM-C7	cem-c7	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	exhibited	exhibit	VBD	VBD	_	0	root	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	steroid	steroid	NN	NN	_	12	compound	_	_
12	responsiveness	responsiveness	NN	NN	_	9	dobj	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	evidenced	evidence	VBN	VBN	_	9	advcl	_	_
15	by	by	IN	IN	_	20	case	_	_
16	increased	increase	VBN	VBN	_	20	amod	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	increased	increase	VBN	VBN	_	23	amod	_	_
23	induction	induction	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	glutamine	glutamine	NN	NN	_	26	compound	_	_
26	synthetase	synthetase	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	and	and	CC	CC	_	20	cc	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lysis	lysis	NN	NN	_	20	conj	_	_
31	at	at	IN	IN	_	33	case	_	_
32	lower	lower	JJR	JJR	_	33	amod	_	_
33	concentrations	concentration	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	steroid	steroid	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	Receptor	receptor	NN	NN	_	3	compound	_	_
2	mutant	mutant	NN	NN	_	3	compound	_	_
3	subclones	subclone	NNS	NNS	_	25	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CEM-C7	cem-c7	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	proven	prove	VBN	VBN	_	3	acl:relcl	_	_
10	to	to	TO	TO	_	13	mark	_	_
11	be	be	VB	VB	_	13	cop	_	_
12	completely	completely	RB	RB	_	13	advmod	_	_
13	unresponsive	unresponsive	JJ	JJ	_	9	xcomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	micromolar	micromolar	JJ	JJ	_	16	amod	_	_
16	concentrations	concentration	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	dexamethasone	dexamethasone	NN	NN	_	16	nmod	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	grown	grow	VBN	VBN	_	9	advcl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	serum-supplemented	serum-supplemented	JJ	JJ	_	23	amod	_	_
23	medium	medium	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	become	become	VBP	VBP	_	0	root	_	_
26	partially	partially	RB	RB	_	27	advmod	_	_
27	sensitive	sensitive	JJ	JJ	_	25	xcomp	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	hormone	hormone	NN	NN	_	27	nmod	_	_
31	after	after	IN	IN	_	32	case	_	_
32	growth	growth	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	defined	define	VBN	VBN	_	35	amod	_	_
35	medium	medium	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	sensitivity	sensitivity	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	CEM-C7	cem-c7	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	subclones	subclone	NNS	NNS	_	6	conj	_	_
10	to	to	TO	TO	_	11	case	_	_
11	dexamethasone	dexamethasone	NN	NN	_	3	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	serum-free	serum-free	JJ	JJ	_	14	amod	_	_
14	medium	medium	NN	NN	_	3	nmod	_	_
15	returned	return	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	18	case	_	_
17	previous	previous	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	15	nmod	_	_
19	when	when	WRB	WRB	_	23	advmod	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	23	nsubjpass	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	recultured	reculture	VBN	VBN	_	15	advcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	serum-containing	serum-containing	JJ	JJ	_	26	amod	_	_
26	medium	medium	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	15	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	substances	substance	NNS	NNS	_	8	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	serum	serum	NN	NN	_	5	nmod	_	_
8	influence	influence	VBP	VBP	_	3	ccomp	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	that	that	IN	IN	_	25	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	details	detail	NNS	NNS	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	22	case	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
21	hormone	hormone	NN	NN	_	22	compound	_	_
22	action	action	NN	NN	_	18	nmod	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	pursued	pursue	VBN	VBN	_	8	conj	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	precisely	precisely	RB	RB	_	25	advmod	_	_
28	in	in	IN	IN	_	33	case	_	_
29	a	a	DT	DT	_	33	det	_	_
30	clearly	clearly	RB	RB	_	31	advmod	_	_
31	defined	define	VBN	VBN	_	33	amod	_	_
32	culture	culture	NN	NN	_	33	compound	_	_
33	medium	medium	NN	NN	_	25	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	monocyte/macrophage-specific	monocyte/macrophage-specific	JJ	JJ	_	4	dep	_	_
6	stimulator	stimulator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	13	case	_	_
8	human	human	JJ	JJ	_	13	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
10	virus	virus	NN	NN	_	13	compound	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	expression	expression	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	LPS	lps	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	potently	potently	RB	RB	_	6	advmod	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	human	human	JJ	JJ	_	18	amod	_	_
8	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
9	virus	virus	NN	NN	_	18	compound	_	_
10	type	type	NN	NN	_	18	compound	_	_
11	1-long	1-long	JJ	JJ	_	18	amod	_	_
12	terminal	terminal	JJ	JJ	_	18	amod	_	_
13	repeat	repeat	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	HIV-1-LTR	hiv-1-ltr	NN	NN	_	18	compound	_	_
16	)	)	-RRB-	-RRB-	_	18	punct	_	_
17	CAT	cat	NN	NN	_	18	compound	_	_
18	constructs	construct	NNS	NNS	_	6	dobj	_	_
19	transfected	transfect	VBN	VBN	_	18	acl	_	_
20	into	into	IN	IN	_	23	case	_	_
21	monocyte/macrophage-like	monocyte/macrophage-like	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	19	nmod	_	_
24	but	but	CC	CC	_	25	cc	_	_
25	not	not	RB	RB	_	23	cc	_	_
26	a	a	DT	DT	_	29	det	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	23	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	3	xcomp	_	_
7	through	through	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
12	factor	factor	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	LPS	lps	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	dobj	_	_
13	indistinguishable	indistinguishable	JJ	JJ	_	12	amod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	U937	u937	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	THP-1	thp-1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	LPS	lps	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	dramatically	dramatically	RB	RB	_	7	advmod	_	_
7	increase	increase	VB	VB	_	4	xcomp	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	from	from	IN	IN	_	17	case	_	_
11	a	a	DT	DT	_	17	det	_	_
12	chronically	chronically	RB	RB	_	17	advmod	_	_
13	infected	infected	JJ	JJ	_	17	amod	_	_
14	monocyte/macrophage-like	monocyte/macrophage-like	JJ	JJ	_	17	amod	_	_
15	cloned	clone	VBN	VBN	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	U1	u1	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	17	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	produces	produce	VBZ	VBZ	_	17	acl:relcl	_	_
23	very	very	RB	RB	_	24	advmod	_	_
24	low	low	JJ	JJ	_	25	amod	_	_
25	levels	level	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HIV-1	hiv-1	NN	NN	_	25	nmod	_	_
28	at	at	IN	IN	_	29	case	_	_
29	baseline	baseline	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	viral	viral	JJ	JJ	_	5	amod	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	from	from	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	5	nmod	_	_
10	occurs	occur	VBZ	VBZ	_	0	root	_	_
11	only	only	RB	RB	_	16	advmod	_	_
12	if	if	IN	IN	_	16	mark	_	_
13	these	these	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	treated	treat	VBN	VBN	_	10	advcl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	20	amod	_	_
19	colony-stimulating	colony-stimulating	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	GM-CSF	gm-csf	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	before	before	IN	IN	_	25	case	_	_
25	treatment	treatment	NN	NN	_	16	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	LPS	lps	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	stimulation	stimulation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	correlated	correlate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	RNA	rna	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	and	and	CC	CC	_	19	cc	_	_
19	activation	activation	NN	NN	_	10	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	LPS	lps	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	able	able	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	induce	induce	VB	VB	_	4	xcomp	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	cloned	clone	VBN	VBN	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	LPS	lps	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	replication	replication	NN	NN	_	2	nmod	_	_
8	occurs	occur	VBZ	VBZ	_	0	root	_	_
9	at	at	IN	IN	_	13	case	_	_
10	picogram	picogram	NN	NN	_	13	compound	_	_
11	per	per	IN	IN	_	12	case	_	_
12	milliliter	milliliter	NN	NN	_	10	nmod	_	_
13	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	may	may	MD	MD	_	18	aux	_	_
16	be	be	VB	VB	_	18	cop	_	_
17	clinically	clinically	RB	RB	_	18	advmod	_	_
18	significant	significant	JJ	JJ	_	8	conj	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	understanding	understand	VBG	VBG	_	18	advcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	variability	variability	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	natural	natural	JJ	JJ	_	26	amod	_	_
26	history	history	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	HIV-1	hiv-1	NN	NN	_	29	compound	_	_
29	infection	infection	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	13	case	_	_
3	the	the	DT	DT	_	13	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	13	compound	_	_
8	2	2	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HIV-2	hiv-2	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	1	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	cytomegalovirus	cytomegalovirus	NN	NN	_	1	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	HIV-2	hiv-2	NN	NN	_	20	compound	_	_
19	transactivator	transactivator	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	compound	_	_
3	virus	virus	NN	NN	_	8	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	HIV	hiv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	often	often	RB	RB	_	8	advmod	_	_
8	causes	cause	VBZ	VBZ	_	0	root	_	_
9	latent	latent	JJ	JJ	_	10	amod	_	_
10	infection	infection	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	8	punct	_	_

1	Transactivation	transactivation	NN	NN	_	8	nsubjpass	_	_
2	by	by	IN	IN	_	5	case	_	_
3	some	some	DT	DT	_	5	det	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	viruses	virus	NNS	NNS	_	1	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	implicated	implicate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	inducing	induce	VBG	VBG	_	8	advcl	_	_
11	HIV-1	hiv-1	NN	NN	_	10	dobj	_	_
12	replication	replication	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	pathogenesis	pathogenesis	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	transactivator	transactivator	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	IE-2	ie-2	NN	NN	_	6	compound	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	gene	gene	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	cytomegalovirus	cytomegalovirus	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CMV	cmv	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	enhance	enhance	VB	VB	_	0	root	_	_
16	HIV-2	hiv-2	NN	NN	_	15	dobj	_	_
17	as	as	RB	RB	_	16	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	HIV-1	hiv-1	NN	NN	_	16	conj	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	16	dep	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	15	advmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inducer	inducer	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	act	act	VB	VB	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	concert	concert	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	dep	_	_
9	HIV-2	hiv-2	NN	NN	_	11	compound	_	_
10	tat	tat	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	conj	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	enhancing	enhance	VBG	VBG	_	4	advcl	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	While	while	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	HIV-2	hiv-2	NN	NN	_	12	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
6	tat	tat	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	3	conj	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	activators	activator	NNS	NNS	_	3	conj	_	_
11	apparently	apparently	RB	RB	_	12	advmod	_	_
12	employ	employ	VBP	VBP	_	31	advcl	_	_
13	independent	independent	JJ	JJ	_	14	amod	_	_
14	modes	mode	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	action	action	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	31	punct	_	_
18	the	the	DT	DT	_	20	det	_	_
19	CMV	cmv	NN	NN	_	20	compound	_	_
20	transactivator	transactivator	NN	NN	_	31	nsubj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	combination	combination	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	dep	_	_
25	HIV-2	hiv-2	NN	NN	_	26	compound	_	_
26	tat	tat	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	activators	activator	NNS	NNS	_	26	conj	_	_
30	may	may	MD	MD	_	31	aux	_	_
31	employ	employ	VB	VB	_	0	root	_	_
32	a	a	DT	DT	_	35	det	_	_
33	gene	gene	NN	NN	_	35	compound	_	_
34	activation	activation	NN	NN	_	35	compound	_	_
35	pathway	pathway	NN	NN	_	31	dobj	_	_
36	with	with	IN	IN	_	38	case	_	_
37	some	some	DT	DT	_	38	det	_	_
38	common	common	JJ	JJ	_	35	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	some	some	DT	DT	_	41	det	_	_
41	distinct	distinct	JJ	JJ	_	38	conj	_	_
42	components	component	NNS	NNS	_	38	dep	_	_
43	.	.	.	.	_	31	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	HIV-2	hiv-2	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CMV	cmv	NN	NN	_	5	compound	_	_
5	transactivators	transactivator	NNS	NNS	_	2	conj	_	_
6	enhance	enhance	VBP	VBP	_	0	root	_	_
7	HIV-2	hiv-2	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	6	nmod	_	_
13	involving	involve	VBG	VBG	_	12	acl	_	_
14	transcript	transcript	NN	NN	_	13	dobj	_	_
15	initiation	initiation	NN	NN	_	14	dep	_	_
16	as	as	RB	RB	_	14	cc	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	as	as	IN	IN	_	16	mwe	_	_
19	elongation	elongation	NN	NN	_	14	conj	_	_
20	,	,	,	,	_	6	punct	_	_
21	with	with	IN	IN	_	24	mark	_	_
22	CMV	cmv	NN	NN	_	23	compound	_	_
23	transactivator	transactivator	NN	NN	_	24	nsubj	_	_
24	affecting	affect	VBG	VBG	_	6	advcl	_	_
25	elongation	elongation	NN	NN	_	24	dobj	_	_
26	more	more	JJR	JJR	_	24	advmod	_	_
27	than	than	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	initiation	initiation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	proportion	proportion	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	transcripts	transcript	NNS	NNS	_	3	nmod	_	_
6	appear	appear	VBP	VBP	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	terminate	terminate	VB	VB	_	6	xcomp	_	_
9	prematurely	prematurely	RB	RB	_	8	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	absence	absence	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	transactivators	transactivator	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Deletion	deletion	NN	NN	_	3	compound	_	_
2	mutation	mutation	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	HIV-2	hiv-2	NN	NN	_	9	compound	_	_
7	long	long	JJ	JJ	_	9	amod	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	repeat	repeat	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LTR	ltr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	suggests	suggest	VBZ	VBZ	_	0	root	_	_
14	that	that	IN	IN	_	27	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	element	element	NN	NN	_	27	nsubj	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	responds	respond	VBZ	VBZ	_	16	acl:relcl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	CMV	cmv	NN	NN	_	21	compound	_	_
21	transactivation	transactivation	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	CD4+	cd4+	JJ	JJ	_	25	amod	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	either	either	CC	CC	_	13	ccomp	_	_
28	a	a	DT	DT	_	30	det	_	_
29	diffuse	diffuse	JJ	JJ	_	30	amod	_	_
30	one	one	CD	CD	_	27	dep	_	_
31	or	or	CC	CC	_	27	cc	_	_
32	located	located	JJ	JJ	_	27	conj	_	_
33	downstream	downstream	RB	RB	_	32	advmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	HIV-2	hiv-2	NN	NN	_	38	compound	_	_
37	enhancer	enhancer	NN	NN	_	38	compound	_	_
38	element	element	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	Sequence-specific	sequence-specific	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	proto-oncoprotein	proto-oncoprotein	NN	NN	_	3	nmod	_	_
7	ets-1	ets-1	NN	NN	_	6	dep	_	_
8	defines	define	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
11	activator	activator	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	8	dobj	_	_
13	within	within	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	Moloney	moloney	NN	NN	_	23	compound	_	_
21	murine	murine	JJ	JJ	_	23	amod	_	_
22	sarcoma	sarcoma	NN	NN	_	23	compound	_	_
23	virus	virus	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ets	ets	NN	NN	_	4	compound	_	_
3	proto-oncogene	proto-oncogene	NN	NN	_	4	compound	_	_
4	family	family	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	group	group	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	10	case	_	_
9	sequence-related	sequence-related	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	whose	whose	WP$	WP$	_	14	nmod:poss	_	_
12	normal	normal	JJ	JJ	_	14	amod	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	function	function	NN	NN	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	unknown	unknown	JJ	JJ	_	7	acl:relcl	_	_
17	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	21	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	3	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	murine	murine	JJ	JJ	_	14	amod	_	_
14	retroviruses	retrovirus	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
18	,	,	,	,	_	21	punct	_	_
19	we	we	PRP	PRP	_	21	nsubj	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	discovered	discover	VBN	VBN	_	0	root	_	_
22	that	that	IN	IN	_	30	mark	_	_
23	a	a	DT	DT	_	24	det	_	_
24	member	member	NN	NN	_	30	nsubj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	ets	ets	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	family	family	NN	NN	_	24	nmod	_	_
30	encodes	encode	VBZ	VBZ	_	21	ccomp	_	_
31	a	a	DT	DT	_	34	det	_	_
32	sequence-specific	sequence-specific	JJ	JJ	_	34	amod	_	_
33	DNA-binding	dna-binding	JJ	JJ	_	34	amod	_	_
34	protein	protein	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	21	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	mouse	mouse	NN	NN	_	5	compound	_	_
3	ets-1	ets-1	NN	NN	_	5	compound	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	clone	clone	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	obtained	obtain	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	screening	screen	VBG	VBG	_	7	advcl	_	_
10	a	a	DT	DT	_	15	det	_	_
11	mouse	mouse	NN	NN	_	15	compound	_	_
12	thymus	thymus	NN	NN	_	15	compound	_	_
13	cDNA	cdna	NN	NN	_	15	compound	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	library	library	NN	NN	_	9	dobj	_	_
16	with	with	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	double-stranded	double-stranded	JJ	JJ	_	20	amod	_	_
19	oligonucleotide	oligonucleotide	NN	NN	_	20	compound	_	_
20	probe	probe	NN	NN	_	9	nmod	_	_
21	representing	represent	VBG	VBG	_	20	acl	_	_
22	20	20	CD	CD	_	23	nummod	_	_
23	bp	bp	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	Moloney	moloney	NN	NN	_	23	nmod	_	_
27	murine	murine	JJ	JJ	_	29	amod	_	_
28	sarcoma	sarcoma	NN	NN	_	29	compound	_	_
29	virus	virus	NN	NN	_	26	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	MSV	msv	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	long	long	JJ	JJ	_	35	amod	_	_
34	terminal	terminal	JJ	JJ	_	35	amod	_	_
35	repeat	repeat	NN	NN	_	26	dep	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	LTR	ltr	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	9	det	_	_
6	813-bp	813-bp	JJ	JJ	_	9	amod	_	_
7	open	open	JJ	JJ	_	9	amod	_	_
8	reading	reading	NN	NN	_	9	compound	_	_
9	frame	frame	NN	NN	_	4	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ORF	orf	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	whose	whose	WP$	WP$	_	17	nmod:poss	_	_
14	predicted	predict	VBN	VBN	_	17	amod	_	_
15	amino	amino	NN	NN	_	17	compound	_	_
16	acid	acid	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	21	nsubj	_	_
18	is	be	VBZ	VBZ	_	21	cop	_	_
19	97.6	97.6	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	21	nmod:npmod	_	_
21	identical	identical	JJ	JJ	_	9	acl:relcl	_	_
22	to	to	TO	TO	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	272	272	CD	CD	_	27	nummod	_	_
25	carboxy-terminal	carboxy-terminal	JJ	JJ	_	27	amod	_	_
26	amino	amino	NN	NN	_	27	compound	_	_
27	acids	acid	NNS	NNS	_	21	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	ets-1	ets-1	NN	NN	_	32	compound	_	_
32	protein	protein	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ORF	orf	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	bacteria	bacterium	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	the	the	DT	DT	_	12	det	_	_
10	30-kD	30-kd	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	product	product	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	4	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	bind	bind	VB	VB	_	14	xcomp	_	_
17	DNA	dna	NN	NN	_	16	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	sequence-specific	sequence-specific	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	16	nmod	_	_
22	by	by	IN	IN	_	24	case	_	_
23	mobility-shift	mobility-shift	JJ	JJ	_	24	amod	_	_
24	assays	assay	NNS	NNS	_	14	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	Southwestern	southwestern	NN	NN	_	28	compound	_	_
27	blot	blot	NN	NN	_	28	compound	_	_
28	analysis	analysis	NN	NN	_	24	conj	_	_
29	,	,	,	,	_	24	punct	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	methylation	methylation	NN	NN	_	32	compound	_	_
32	interference	interference	NN	NN	_	24	conj	_	_
33	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	mutant	mutant	JJ	JJ	_	3	amod	_	_
3	LTR	ltr	NN	NN	_	15	nsubjpass	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	four	four	CD	CD	_	8	nummod	_	_
6	base	base	NN	NN	_	8	compound	_	_
7	pair	pair	NN	NN	_	8	compound	_	_
8	substitutions	substitution	NNS	NNS	_	4	dobj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	ets-1	ets-1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	4	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	constructed	construct	VBN	VBN	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	15	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	have	have	VB	VB	_	18	xcomp	_	_
21	reduced	reduce	VBN	VBN	_	22	amod	_	_
22	binding	binding	NN	NN	_	20	dobj	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	20	advmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	efficiency	efficiency	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	MSV	msv	NN	NN	_	7	compound	_	_
6	LTR	ltr	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	2	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	this	this	DT	DT	_	13	det	_	_
10	disrupted	disrupt	VBN	VBN	_	13	amod	_	_
11	ets-1	ets-1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	dobj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	compared	compare	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	wild-type	wild-type	JJ	JJ	_	22	amod	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	mouse	mouse	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	culture	culture	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	15	punct	_	_
30	and	and	CC	CC	_	15	cc	_	_
31	15-	15-	CD	CD	_	33	compound	_	_
32	to	to	TO	TO	_	33	dep	_	_
33	20-fold	20-fold	JJ	JJ	_	34	amod	_	_
34	reduction	reduction	NN	NN	_	42	nsubjpass	_	_
35	in	in	IN	IN	_	36	case	_	_
36	expression	expression	NN	NN	_	34	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	reporter	reporter	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	36	nmod	_	_
41	was	be	VBD	VBD	_	42	auxpass	_	_
42	observed	observe	VBN	VBN	_	15	conj	_	_
43	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	ets-1	ets-1	NN	NN	_	5	nsubj	_	_
5	functions	function	VBZ	VBZ	_	2	ccomp	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activator	activator	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	mammalian	mammalian	JJ	JJ	_	13	amod	_	_
12	type-C	type-c	JJ	JJ	_	13	amod	_	_
13	retroviruses	retrovirus	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	2	cc	_	_
15	speculate	speculate	VBP	VBP	_	2	conj	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	ets-related	ets-related	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	19	nsubj	_	_
19	constitute	constitute	VBP	VBP	_	15	ccomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	new	new	JJ	JJ	_	22	amod	_	_
22	group	group	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	eukaryotic	eukaryotic	JJ	JJ	_	26	amod	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	a	a	DT	DT	_	9	det	_	_
4	transcriptionally	transcriptionally	RB	RB	_	9	advmod	_	_
5	active	active	JJ	JJ	_	9	amod	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	TATA	tata	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	IID	iid	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TFIID	tfiid	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	binds	bind	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	TATA	tata	NN	NN	_	13	compound	_	_
11	box	box	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	regulates	regulate	VBZ	VBZ	_	7	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	most	most	JJS	JJS	_	21	amod	_	_
20	eukaryotic	eukaryotic	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	transcribed	transcribe	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	RNA	rna	NN	NN	_	25	compound	_	_
25	polymerase	polymerase	NN	NN	_	22	nmod	_	_
26	II	ii	CD	CD	_	25	nummod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Complementary	complementary	JJ	JJ	_	2	amod	_	_
2	DNA	dna	NN	NN	_	13	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	cDNA	cdna	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	encoding	encode	VBG	VBG	_	2	acl	_	_
7	a	a	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	TFIID	tfiid	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	dobj	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	cloned	clone	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	TFIID	tfiid	NN	NN	_	4	compound	_	_
4	polypeptide	polypeptide	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	339	339	CD	CD	_	8	nummod	_	_
7	amino	amino	NN	NN	_	8	compound	_	_
8	acids	acid	NNS	NNS	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	12	det	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	size	size	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	37,745	37,745	CD	CD	_	15	nummod	_	_
15	daltons	dalton	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	5	amod	_	_
3	181	181	CD	CD	_	5	nummod	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	TFIID	tfiid	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	5	nmod	_	_
11	shares	share	VBZ	VBZ	_	0	root	_	_
12	80	80	CD	CD	_	13	compound	_	_
13	%	%	NN	NN	_	14	amod	_	_
14	identity	identity	NN	NN	_	11	dobj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	TFIID	tfiid	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	11	nmod	_	_
19	from	from	IN	IN	_	21	case	_	_
20	Saccharomyces	saccharomyces	FW	FW	_	21	compound	_	_
21	cerevisiae	cerevisiae	FW	FW	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	amino	amino	NN	NN	_	3	compound	_	_
3	terminus	terminus	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	unusual	unusual	JJ	JJ	_	7	amod	_	_
7	repeat	repeat	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	38	38	CD	CD	_	12	nummod	_	_
10	consecutive	consecutive	JJ	JJ	_	12	amod	_	_
11	glutamine	glutamine	NN	NN	_	12	compound	_	_
12	residues	residue	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	an	a	DT	DT	_	16	det	_	_
15	X-Thr-Pro	x-thr-pro	NN	NN	_	16	compound	_	_
16	repeat	repeat	NN	NN	_	7	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	DNA	dna	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	reticulocyte	reticulocyte	NN	NN	_	6	compound	_	_
6	lysates	lysate	NNS	NNS	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	in	in	IN	IN	_	10	case	_	_
9	Escherichia	escherichia	FW	FW	_	10	compound	_	_
10	coli	coli	FW	FW	_	6	conj	_	_
11	yielded	yield	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	13	det	_	_
13	protein	protein	NN	NN	_	11	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	competent	competent	JJ	JJ	_	13	acl:relcl	_	_
17	for	for	IN	IN	_	20	case	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	11	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	leukocyte	leukocyte	NN	NN	_	0	root	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	2	dep	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	characteristics	characteristic	NNS	NNS	_	2	dep	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	down-regulation	down-regulation	NN	NN	_	2	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	major	major	JJ	JJ	_	11	amod	_	_
11	depression	depression	NN	NN	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	10	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	major	major	JJ	JJ	_	6	amod	_	_
5	depressive	depressive	JJ	JJ	_	6	amod	_	_
6	disorder	disorder	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	MDD	mdd	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	have	have	VBP	VBP	_	0	root	_	_
11	elevated	elevated	JJ	JJ	_	14	amod	_	_
12	plasma	plasma	NN	NN	_	14	compound	_	_
13	cortisol	cortisol	NN	NN	_	14	compound	_	_
14	concentrations	concentration	NNS	NNS	_	10	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	show	show	VBP	VBP	_	10	conj	_	_
17	failure	failure	NN	NN	_	16	dobj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	suppress	suppress	VB	VB	_	17	acl	_	_
20	cortisol	cortisol	NN	NN	_	21	compound	_	_
21	secretion	secretion	NN	NN	_	19	dobj	_	_
22	upon	upon	IN	IN	_	23	case	_	_
23	administration	administration	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	dexamethasone	dexamethasone	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	DEX	dex	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	10	punct	_	_
30	yet	yet	CC	CC	_	10	cc	_	_
31	they	they	PRP	PRP	_	34	nsubj	_	_
32	do	do	VBP	VBP	_	34	aux	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	have	have	VB	VB	_	10	conj	_	_
35	Cushingoid	cushingoid	JJ	JJ	_	36	amod	_	_
36	features	feature	NNS	NNS	_	34	dobj	_	_
37	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	5	mark	_	_
4	this	this	DT	DT	_	5	nsubj	_	_
5	represents	represent	VBZ	VBZ	_	2	ccomp	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	GC	gc	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	resistance	resistance	NN	NN	_	5	dobj	_	_
11	,	,	,	,	_	2	punct	_	_
12	-LSB-3H-RSB--DEX-binding	-lsb-3h-rsb--dex-binding	JJ	JJ	_	13	amod	_	_
13	assays	assay	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	used	use	VBN	VBN	_	2	parataxis	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	measure	measure	VB	VB	_	15	xcomp	_	_
18	,	,	,	,	_	17	punct	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	17	advmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	the	the	DT	DT	_	24	det	_	_
23	GC	gc	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	17	dobj	_	_
25	affinity	affinity	NN	NN	_	24	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	1/Kd	1/kd	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	number	number	NN	NN	_	24	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	Bmax	bmax	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	in	in	IN	IN	_	36	case	_	_
35	mononuclear	mononuclear	JJ	JJ	_	36	amod	_	_
36	leukocytes	leukocyte	NNS	NNS	_	24	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	11	11	CD	CD	_	40	nummod	_	_
39	MDD	mdd	NN	NN	_	40	compound	_	_
40	patients	patient	NNS	NNS	_	36	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	15	15	CD	CD	_	44	nummod	_	_
43	control	control	JJ	JJ	_	44	amod	_	_
44	subjects	subject	NNS	NNS	_	40	conj	_	_
45	.	.	.	.	_	2	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	abnormalities	abnormality	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	MDD	mdd	NN	NN	_	9	compound	_	_
9	group	group	NN	NN	_	5	nmod	_	_
10	;	;	:	:	_	5	punct	_	_
11	thus	thus	RB	RB	_	32	advmod	_	_
12	any	any	DT	DT	_	14	det	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	defect	defect	NN	NN	_	32	nsubj	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	lack	lack	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	responsiveness	responsiveness	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	GC	gc	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	MDD	mdd	NN	NN	_	26	compound	_	_
26	patients	patient	NNS	NNS	_	18	nmod	_	_
27	,	,	,	,	_	14	punct	_	_
28	if	if	IN	IN	_	32	dep	_	_
29	present	present	JJ	JJ	_	28	dep	_	_
30	,	,	,	,	_	32	punct	_	_
31	probably	probably	RB	RB	_	32	advmod	_	_
32	lies	lie	VBZ	VBZ	_	5	parataxis	_	_
33	beyond	beyond	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	initial	initial	JJ	JJ	_	37	amod	_	_
36	receptor	receptor	NN	NN	_	37	compound	_	_
37	binding	binding	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	DEX	dex	NN	NN	_	8	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	1.0	1.0	CD	CD	_	4	nummod	_	_
4	mg	mg	NN	NN	_	1	dep	_	_
5	orally	orally	RB	RB	_	4	advmod	_	_
6	)	)	-RRB-	-RRB-	_	4	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	administered	administer	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	study	study	VB	VB	_	8	xcomp	_	_
11	in	in	FW	FW	_	15	amod	_	_
12	vivo	vivo	FW	FW	_	11	dep	_	_
13	GC	gc	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	down-regulation	down-regulation	NN	NN	_	10	dobj	_	_
16	.	.	.	.	_	8	punct	_	_

1	Compared	compare	VBN	VBN	_	5	case	_	_
2	to	to	TO	TO	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	control	control	JJ	JJ	_	5	amod	_	_
5	group	group	NN	NN	_	10	advcl	_	_
6	,	,	,	,	_	10	punct	_	_
7	fewer	fewer	JJR	JJR	_	9	amod	_	_
8	depressed	depressed	JJ	JJ	_	9	amod	_	_
9	subjects	subject	NNS	NNS	_	10	nsubj	_	_
10	down-regulated	down-regulate	VBD	VBD	_	0	root	_	_
11	Bmax	bmax	NN	NN	_	10	dobj	_	_
12	after	after	IN	IN	_	13	case	_	_
13	DEX	dex	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	paired	paired	JJ	JJ	_	3	amod	_	_
3	t-test	t-test	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	Bmax	bmax	NN	NN	_	6	nsubj	_	_
6	decreased	decrease	VBD	VBD	_	0	root	_	_
7	significantly	significantly	RB	RB	_	6	advmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	control	control	JJ	JJ	_	11	amod	_	_
11	group	group	NN	NN	_	6	nmod	_	_
12	but	but	CC	CC	_	11	cc	_	_
13	not	not	RB	RB	_	17	neg	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	depressed	depressed	JJ	JJ	_	17	amod	_	_
17	group	group	NN	NN	_	11	conj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Receptor	receptor	NN	NN	_	2	compound	_	_
2	number	number	NN	NN	_	9	nsubj	_	_
3	on	on	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	control	control	JJ	JJ	_	6	amod	_	_
6	day	day	NN	NN	_	2	nmod	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	correlate	correlate	VB	VB	_	0	root	_	_
10	significantly	significantly	RB	RB	_	9	advmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	degree	degree	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	down-regulation	down-regulation	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	severity	severity	NN	NN	_	13	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	depression	depression	NN	NN	_	18	nmod	_	_
21	or	or	CC	CC	_	13	cc	_	_
22	cortisol	cortisol	NN	NN	_	23	compound	_	_
23	concentrations	concentration	NNS	NNS	_	13	conj	_	_
24	across	across	IN	IN	_	27	case	_	_
25	all	all	PDT	PDT	_	27	det:predet	_	_
26	the	the	DT	DT	_	27	det	_	_
27	subjects	subject	NNS	NNS	_	13	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	do	do	VBP	VBP	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	lend	lend	VB	VB	_	0	root	_	_
6	support	support	NN	NN	_	5	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	previous	previous	JJ	JJ	_	9	amod	_	_
9	reports	report	NNS	NNS	_	5	nmod	_	_
10	suggesting	suggest	VBG	VBG	_	9	acl	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	GC	gc	NN	NN	_	13	compound	_	_
13	resistance	resistance	NN	NN	_	16	nsubj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	MDD	mdd	NN	NN	_	13	nmod	_	_
16	results	result	VBZ	VBZ	_	10	ccomp	_	_
17	from	from	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	GC	gc	NN	NN	_	21	compound	_	_
20	receptor-binding	receptor-binding	JJ	JJ	_	21	amod	_	_
21	abnormality	abnormality	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	5	punct	_	_
23	and	and	CC	CC	_	5	cc	_	_
24	they	they	PRP	PRP	_	25	nsubj	_	_
25	emphasize	emphasize	VBP	VBP	_	5	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	importance	importance	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	mark	_	_
29	considering	consider	VBG	VBG	_	27	acl	_	_
30	receptor	receptor	NN	NN	_	31	compound	_	_
31	studies	study	NNS	NNS	_	29	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	context	context	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	GC-mediated	gc-mediated	JJ	JJ	_	38	amod	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	processes	process	NNS	NNS	_	34	nmod	_	_
39	in	in	IN	IN	_	42	mark	_	_
40	order	order	NN	NN	_	39	mwe	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	identify	identify	VB	VB	_	29	advcl	_	_
43	the	the	DT	DT	_	48	det	_	_
44	exact	exact	JJ	JJ	_	48	amod	_	_
45	cellular	cellular	JJ	JJ	_	48	amod	_	_
46	defect	defect	NN	NN	_	48	compound	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	s	s	NNS	NNS	_	42	dobj	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	leading	lead	VBG	VBG	_	48	acl	_	_
51	to	to	TO	TO	_	53	case	_	_
52	GC	gc	NN	NN	_	53	compound	_	_
53	resistance	resistance	NN	NN	_	50	nmod	_	_
54	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
3	virus	virus	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	EBV	ebv	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	BMRF1	bmrf1	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	16	nsubjpass	_	_
9	for	for	IN	IN	_	11	case	_	_
10	early	early	JJ	JJ	_	11	amod	_	_
11	antigen	antigen	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	EA-D	ea-d	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	EBV	ebv	NN	NN	_	20	compound	_	_
20	transactivators	transactivator	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	BRLF1	brlf1	NN	NN	_	20	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	BZLF1	bzlf1	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	16	punct	_	_
26	in	in	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	cell-specific	cell-specific	JJ	JJ	_	29	amod	_	_
29	manner	manner	NN	NN	_	16	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
3	virus	virus	NN	NN	_	7	compound	_	_
4	early	early	JJ	JJ	_	7	amod	_	_
5	antigen	antigen	NN	NN	_	7	compound	_	_
6	diffuse	diffuse	NN	NN	_	7	compound	_	_
7	component	component	NN	NN	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EA-D	ea-d	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	essential	essential	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	18	case	_	_
14	Epstein-Barr	epstein-barr	JJ	JJ	_	18	amod	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	polymerase	polymerase	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	activity	activity	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	suppressed	suppress	VBN	VBN	_	12	conj	_	_
25	during	during	IN	IN	_	27	case	_	_
26	latent	latent	JJ	JJ	_	27	amod	_	_
27	infection	infection	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	promoter	promoter	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	BMRF1	bmrf1	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	for	for	IN	IN	_	14	case	_	_
12	this	this	DT	DT	_	14	det	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	gene	gene	NN	NN	_	7	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	studying	study	VBG	VBG	_	2	advcl	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	responsiveness	responsiveness	NN	NN	_	16	dobj	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	18	advmod	_	_
21	to	to	TO	TO	_	25	case	_	_
22	two	two	CD	CD	_	25	nummod	_	_
23	immediate-early	immediate-early	JJ	JJ	_	25	amod	_	_
24	viral	viral	JJ	JJ	_	25	amod	_	_
25	transactivators	transactivator	NNS	NNS	_	18	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	BZLF1	bzlf1	NN	NN	_	25	appos	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	Z	z	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	BRLF1	brlf1	NN	NN	_	27	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	R	r	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	2	punct	_	_
37	focusing	focus	VBG	VBG	_	2	advcl	_	_
38	on	on	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	differences	difference	NNS	NNS	_	37	nmod	_	_
41	in	in	IN	IN	_	42	case	_	_
42	response	response	NN	NN	_	40	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	lymphoid	lymphoid	JJ	JJ	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	epithelial	epithelial	JJ	JJ	_	48	amod	_	_
48	cells	cell	NNS	NNS	_	45	conj	_	_
49	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	Z	z	NN	NN	_	9	nsubj	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	R	r	NN	NN	_	5	conj	_	_
8	alone	alone	RB	RB	_	5	advmod	_	_
9	produced	produce	VBD	VBD	_	0	root	_	_
10	only	only	RB	RB	_	12	advmod	_	_
11	small	small	JJ	JJ	_	12	amod	_	_
12	increases	increase	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	EA-D	ea-d	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	9	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	whereas	whereas	IN	IN	_	22	mark	_	_
19	both	both	DT	DT	_	20	dep	_	_
20	transactivators	transactivator	NNS	NNS	_	22	nsubj	_	_
21	together	together	RB	RB	_	22	advmod	_	_
22	produced	produce	VBD	VBD	_	9	advcl	_	_
23	a	a	DT	DT	_	26	det	_	_
24	large	large	JJ	JJ	_	26	amod	_	_
25	stimulatory	stimulatory	JJ	JJ	_	26	amod	_	_
26	effect	effect	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	epithelial	epithelial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Z	z	NN	NN	_	7	compound	_	_
7	transactivator	transactivator	NN	NN	_	9	nsubj	_	_
8	alone	alone	RB	RB	_	7	advmod	_	_
9	produced	produce	VBD	VBD	_	0	root	_	_
10	maximal	maximal	JJ	JJ	_	11	amod	_	_
11	stimulation	stimulation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	EA-D	ea-d	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	;	;	:	:	_	9	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	26	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	R	r	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Z	z	NN	NN	_	20	conj	_	_
23	together	together	RB	RB	_	20	advmod	_	_
24	was	be	VBD	VBD	_	26	cop	_	_
25	no	no	DT	DT	_	26	neg	_	_
26	greater	greater	JJR	JJR	_	9	parataxis	_	_
27	than	than	IN	IN	_	28	case	_	_
28	that	that	DT	DT	_	26	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	Z	z	NN	NN	_	28	nmod	_	_
31	alone	alone	RB	RB	_	30	advmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Deletional	deletional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	site-directed	site-directed	JJ	JJ	_	5	amod	_	_
5	mutagenesis	mutagenesis	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	EA-D	ea-d	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	2	nmod	_	_
10	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	20	mark	_	_
12	in	in	IN	IN	_	14	case	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	20	nmod	_	_
15	the	the	DT	DT	_	19	det	_	_
16	potential	potential	JJ	JJ	_	19	amod	_	_
17	AP-1	ap-1	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	20	nsubj	_	_
20	plays	play	VBZ	VBZ	_	10	ccomp	_	_
21	an	a	DT	DT	_	23	det	_	_
22	essential	essential	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	Z	z	NN	NN	_	26	compound	_	_
26	responsiveness	responsiveness	NN	NN	_	20	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	although	although	IN	IN	_	34	mark	_	_
29	sequences	sequence	NNS	NNS	_	34	nsubj	_	_
30	further	further	RB	RB	_	31	advmod	_	_
31	upstream	upstream	JJ	JJ	_	29	advmod	_	_
32	are	be	VBP	VBP	_	34	cop	_	_
33	also	also	RB	RB	_	34	advmod	_	_
34	important	important	JJ	JJ	_	20	advcl	_	_
35	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	only	only	RB	RB	_	8	advmod	_	_
6	the	the	DT	DT	_	8	det	_	_
7	upstream	upstream	JJ	JJ	_	8	amod	_	_
8	sequences	sequence	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	transactivation	transactivation	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	Z/R	z/r	NN	NN	_	16	compound	_	_
16	combination	combination	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	the	the	DT	DT	_	21	det	_	_
20	AP-1	ap-1	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	dispensable	dispensable	JJ	JJ	_	10	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	EA-D	ea-d	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	BMRF1	bmrf1	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	18	nsubj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	Z	z	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	R	r	NN	NN	_	12	conj	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	cell	cell	NN	NN	_	18	nmod:npmod	_	_
17	type	type	NN	NN	_	18	nmod:npmod	_	_
18	specific	specific	JJ	JJ	_	3	ccomp	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	appears	appear	VBZ	VBZ	_	18	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	involve	involve	VB	VB	_	20	xcomp	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	each	each	DT	DT	_	28	det	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	type	type	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Inducible	inducible	JJ	JJ	_	4	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	21	nsubjpass	_	_
5	to	to	TO	TO	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	15	compound	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	4	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	can	can	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	blocked	block	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	24	case	_	_
23	cyclosporin	cyclosporin	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	signal-dependent	signal-dependent	JJ	JJ	_	28	amod	_	_
28	manner	manner	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CsA	csa	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	thought	think	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	exert	exert	VB	VB	_	7	xcomp	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	immunosuppressive	immunosuppressive	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	9	dobj	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	inhibiting	inhibit	VBG	VBG	_	9	advcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	distinct	distinct	JJ	JJ	_	20	amod	_	_
20	set	set	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	lymphokine	lymphokine	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	which	which	WDT	WDT	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	induced	induce	VBN	VBN	_	20	acl:relcl	_	_
27	upon	upon	IN	IN	_	29	case	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	20	punct	_	_
31	among	among	IN	IN	_	32	case	_	_
32	them	they	PRP	PRP	_	20	nmod	_	_
33	the	the	DT	DT	_	34	det	_	_
34	gene	gene	NN	NN	_	20	dep	_	_
35	coding	code	VBG	VBG	_	34	acl	_	_
36	for	for	IN	IN	_	37	case	_	_
37	interleukin-2	interleukin-2	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	10	compound	_	_
10	virus	virus	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HIV	hiv	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	partially	partially	RB	RB	_	16	advmod	_	_
16	suppressed	suppress	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
7	underlying	underlie	VBG	VBG	_	6	acl	_	_
8	suppression	suppression	NN	NN	_	7	dobj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	CsA	csa	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	investigated	investigate	VBN	VBN	_	3	parataxis	_	_
15	the	the	DT	DT	_	16	det	_	_
16	effects	effect	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	drug	drug	NN	NN	_	16	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	16	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	32	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	formation	formation	NN	NN	_	32	nsubjpass	_	_
7	of	of	IN	IN	_	12	case	_	_
8	two	two	CD	CD	_	12	nummod	_	_
9	distinct	distinct	JJ	JJ	_	12	amod	_	_
10	mitogen-inducible	mitogen-inducible	JJ	JJ	_	12	amod	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	17	det	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	12	appos	_	_
18	within	within	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	HIV	hiv	NN	NN	_	21	compound	_	_
21	enhancer	enhancer	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	NFAT-1	nfat-1	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	17	conj	_	_
26	within	within	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	interleukin-2	interleukin-2	NN	NN	_	29	compound	_	_
29	enhancer	enhancer	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	6	punct	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	presence	presence	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	CsA	csa	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B-binding	b-binding	JJ	JJ	_	4	amod	_	_
4	activity	activity	NN	NN	_	10	nsubjpass	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	enhancer	enhancer	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	only	only	RB	RB	_	15	advmod	_	_
12	if	if	IN	IN	_	15	mark	_	_
13	it	it	PRP	PRP	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	10	advcl	_	_
16	via	via	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	mitogen	mitogen	NN	NN	_	15	nmod	_	_
19	phytohemagglutinin	phytohemagglutinin	NN	NN	_	18	dep	_	_
20	whereas	whereas	IN	IN	_	27	mark	_	_
21	phorbol	phorbol	NN	NN	_	23	nmod:npmod	_	_
22	myristate	myristate	NN	NN	_	23	nmod:npmod	_	_
23	acetate-mediated	acetate-mediated	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	27	nsubj	_	_
25	is	be	VBZ	VBZ	_	27	cop	_	_
26	completely	completely	RB	RB	_	27	advmod	_	_
27	insensitive	insensitive	JJ	JJ	_	10	advcl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	drug	drug	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	14	nmod	_	_
7	functionally	functionally	RB	RB	_	8	advmod	_	_
8	indistinguishable	indistinguishable	JJ	JJ	_	11	amod	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	complexes	complex	NNS	NNS	_	14	nsubjpass	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	activated	activate	VBN	VBN	_	4	acl:relcl	_	_
15	via	via	IN	IN	_	18	case	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	separate	separate	JJ	JJ	_	18	amod	_	_
18	pathways	pathway	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	signal	signal	NN	NN	_	21	compound	_	_
21	transduction	transduction	NN	NN	_	18	nmod	_	_
22	distinguishable	distinguishable	JJ	JJ	_	18	amod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	CsA	csa	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	distinct	distinct	JJ	JJ	_	3	amod	_	_
3	forms	form	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	active	active	JJ	JJ	_	8	amod	_	_
6	transcription	transcription	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	CREB	creb	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	14	punct	_	_
10	cAMP	camp	NN	NN	_	14	compound	_	_
11	response	response	NN	NN	_	14	compound	_	_
12	element	element	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	3	punct	_	_

1	Mammalian	mammalian	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	distinct	distinct	JJ	JJ	_	6	amod	_	_
6	forms	form	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	CREB	creb	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	cAMP	camp	NN	NN	_	16	compound	_	_
13	response	response	NN	NN	_	16	compound	_	_
14	element	element	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	10	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	that	that	WDT	WDT	_	22	nsubj	_	_
19	are	be	VBP	VBP	_	22	cop	_	_
20	apparently	apparently	RB	RB	_	22	advmod	_	_
21	the	the	DT	DT	_	22	det	_	_
22	products	product	NNS	NNS	_	10	acl:relcl	_	_
23	of	of	IN	IN	_	25	case	_	_
24	alternative	alternative	JJ	JJ	_	25	amod	_	_
25	splicing	splicing	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	CREB	creb	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	transcript	transcript	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	differ	differ	VBP	VBP	_	0	root	_	_
5	by	by	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	14-amino	14-amino	NN	NN	_	10	compound	_	_
8	acid	acid	NN	NN	_	10	compound	_	_
9	serine-rich	serine-rich	JJ	JJ	_	10	amod	_	_
10	insertion	insertion	NN	NN	_	4	nmod	_	_
11	present	present	JJ	JJ	_	10	amod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	one	one	CD	CD	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CREB	creb	NN	NN	_	17	compound	_	_
17	isoforms	isoform	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	both	both	DT	DT	_	6	dep	_	_
5	CREB	creb	NN	NN	_	6	compound	_	_
6	isoforms	isoform	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	2	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	many	many	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	types	type	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	mammalian	mammalian	JJ	JJ	_	15	amod	_	_
15	species	species	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	nsubj	_	_
2	encode	encode	VBP	VBP	_	0	root	_	_
3	proteins	protein	NNS	NNS	_	2	dobj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	bind	bind	VBP	VBP	_	3	acl:relcl	_	_
6	specifically	specifically	RB	RB	_	5	advmod	_	_
7	to	to	TO	TO	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	cAMP	camp	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	5	nmod	_	_
12	in	in	FW	FW	_	11	compound	_	_
13	vitro	vitro	FW	FW	_	11	dep	_	_
14	.	.	.	.	_	2	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	12	advcl	_	_
3	for	for	IN	IN	_	4	case	_	_
4	proteins	protein	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	class	class	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CREB	creb	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	12	nsubj	_	_
12	bind	bind	VBP	VBP	_	0	root	_	_
13	DNA	dna	NN	NN	_	12	dobj	_	_
14	as	as	IN	IN	_	15	case	_	_
15	dimers	dimer	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	3	nsubj	_	_
3	impart	impart	VBP	VBP	_	0	root	_	_
4	cAMP-regulated	camp-regulated	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	heterologous	heterologous	JJ	JJ	_	11	amod	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	showing	show	VBG	VBG	_	3	advcl	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	cAMP	camp	NN	NN	_	17	nsubj	_	_
16	directly	directly	RB	RB	_	17	advmod	_	_
17	modulates	modulate	VBZ	VBZ	_	13	ccomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
20	stimulatory	stimulatory	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	17	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	CREB	creb	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	multiple	multiple	JJ	JJ	_	6	amod	_	_
5	CREB	creb	NN	NN	_	6	compound	_	_
6	isoforms	isoform	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	identical	identical	JJ	JJ	_	9	amod	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	specificities	specificity	NNS	NNS	_	6	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	differences	difference	NNS	NNS	_	10	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	presumed	presumed	JJ	JJ	_	17	amod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	domain	domain	NN	NN	_	10	nmod	_	_
18	raises	raise	VBZ	VBZ	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	possibility	possibility	NN	NN	_	18	dobj	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	CREB	creb	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	26	nsubj	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	cop	_	_
26	able	able	JJ	JJ	_	20	ccomp	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	integrate	integrate	VB	VB	_	26	xcomp	_	_
29	distinct	distinct	JJ	JJ	_	31	amod	_	_
30	regulatory	regulatory	JJ	JJ	_	31	amod	_	_
31	signals	signal	NNS	NNS	_	28	dobj	_	_
32	at	at	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	level	level	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	transcription	transcription	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	18	punct	_	_

1	Complementary	complementary	JJ	JJ	_	2	amod	_	_
2	DNA	dna	NN	NN	_	0	root	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	T-cell	t-cell	NN	NN	_	8	compound	_	_
7	FK506-binding	fk506-binding	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	3	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	peptidylprolyl	peptidylprolyl	JJ	JJ	_	13	amod	_	_
12	cis-trans	cis-trans	JJ	JJ	_	13	amod	_	_
13	isomerase	isomerase	NN	NN	_	8	appos	_	_
14	distinct	distinct	JJ	JJ	_	13	amod	_	_
15	from	from	IN	IN	_	16	case	_	_
16	cyclophilin	cyclophilin	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	discovered	discover	VBN	VBN	_	4	amod	_	_
4	macrolide	macrolide	NN	NN	_	8	nsubjpass	_	_
5	FK506	fk506	NN	NN	_	4	dep	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	have	have	VB	VB	_	8	xcomp	_	_
11	potent	potent	JJ	JJ	_	13	amod	_	_
12	immunosuppressive	immunosuppressive	JJ	JJ	_	11	dep	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	at	at	IN	IN	_	15	case	_	_
15	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
16	100-fold	100-fold	RB	RB	_	17	nmod:npmod	_	_
17	lower	lower	JJR	JJR	_	15	amod	_	_
18	than	than	IN	IN	_	20	case	_	_
19	cyclosporin	cyclosporin	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	24	det	_	_
23	cyclic	cyclic	JJ	JJ	_	24	amod	_	_
24	undecapeptide	undecapeptide	NN	NN	_	20	appos	_	_
25	that	that	WDT	WDT	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	used	use	VBN	VBN	_	24	acl:relcl	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	prevent	prevent	VB	VB	_	27	xcomp	_	_
30	rejection	rejection	NN	NN	_	29	dobj	_	_
31	after	after	IN	IN	_	32	case	_	_
32	transplantation	transplantation	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	bone	bone	NN	NN	_	35	compound	_	_
35	marrow	marrow	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	organs	organ	NNS	NNS	_	35	conj	_	_
38	,	,	,	,	_	37	punct	_	_
39	such	such	JJ	JJ	_	41	case	_	_
40	as	as	IN	IN	_	39	mwe	_	_
41	kidney	kidney	NN	NN	_	37	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	heart	heart	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	41	punct	_	_
45	and	and	CC	CC	_	41	cc	_	_
46	liver	liver	NN	NN	_	41	conj	_	_
47	.	.	.	.	_	8	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	recent	recent	JJ	JJ	_	4	amod	_	_
4	discovery	discovery	NN	NN	_	25	nmod	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	cyclosporin	cyclosporin	NN	NN	_	9	compound	_	_
8	A-binding	a-binding	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	12	nsubj	_	_
10	cyclophilin	cyclophilin	NN	NN	_	9	dep	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	identical	identical	JJ	JJ	_	4	ccomp	_	_
13	to	to	TO	TO	_	16	case	_	_
14	peptidylprolyl	peptidylprolyl	JJ	JJ	_	16	amod	_	_
15	cis-trans	cis-trans	JJ	JJ	_	16	amod	_	_
16	isomerase	isomerase	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	25	punct	_	_
18	a	a	DT	DT	_	21	det	_	_
19	cellular	cellular	JJ	JJ	_	21	amod	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	25	nsubjpass	_	_
22	for	for	IN	IN	_	23	case	_	_
23	FK506	fk506	NN	NN	_	21	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	found	find	VBN	VBN	_	0	root	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	be	be	VB	VB	_	28	cop	_	_
28	distinct	distinct	JJ	JJ	_	25	ccomp	_	_
29	from	from	IN	IN	_	30	case	_	_
30	cyclophilin	cyclophilin	NN	NN	_	28	nmod	_	_
31	but	but	CC	CC	_	28	cc	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	have	have	VB	VB	_	28	conj	_	_
34	the	the	DT	DT	_	37	det	_	_
35	same	same	JJ	JJ	_	37	amod	_	_
36	enzymatic	enzymatic	JJ	JJ	_	37	amod	_	_
37	activity	activity	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	isolated	isolate	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	cDNA	cdna	NN	NN	_	6	dobj	_	_
9	coding	code	VBG	VBG	_	8	acl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	FK506-binding	fk506-binding	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	FKBP	fkbp	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	from	from	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
19	blood	blood	NN	NN	_	6	nmod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	19	dep	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	using	use	VBG	VBG	_	6	advcl	_	_
24	mixed	mixed	JJ	JJ	_	27	amod	_	_
25	20-mer	20-mer	JJ	JJ	_	24	dep	_	_
26	oligonucleotide	oligonucleotide	NN	NN	_	27	compound	_	_
27	probes	probe	NNS	NNS	_	23	dobj	_	_
28	synthesized	synthesize	VBN	VBN	_	27	acl	_	_
29	on	on	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	basis	basis	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	sequence	sequence	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	Glu-Asp-Gly-Lys-Lys-Phe-Asp	glu-asp-gly-lys-lys-phe-asp	NN	NN	_	34	appos	_	_
37	,	,	,	,	_	34	punct	_	_
38	reported	report	VBN	VBN	_	34	acl	_	_
39	for	for	IN	IN	_	41	case	_	_
40	bovine	bovine	JJ	JJ	_	41	amod	_	_
41	FKBP	fkbp	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	DNA	dna	NN	NN	_	4	nsubj	_	_
3	isolated	isolate	VBN	VBN	_	2	acl	_	_
4	contained	contain	VBD	VBD	_	0	root	_	_
5	an	a	DT	DT	_	8	det	_	_
6	open	open	JJ	JJ	_	8	amod	_	_
7	reading	reading	NN	NN	_	8	compound	_	_
8	frame	frame	NN	NN	_	4	dobj	_	_
9	encoding	encode	VBG	VBG	_	8	acl	_	_
10	108	108	CD	CD	_	13	nummod	_	_
11	amino	amino	NN	NN	_	13	compound	_	_
12	acid	acid	NN	NN	_	13	compound	_	_
13	residues	residue	NNS	NNS	_	9	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	first	first	JJ	JJ	_	4	amod	_	_
3	40	40	CD	CD	_	4	nummod	_	_
4	residues	residue	NNS	NNS	_	12	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	deduced	deduce	VBN	VBN	_	10	amod	_	_
8	amino	amino	NN	NN	_	10	compound	_	_
9	acid	acid	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	4	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	identical	identical	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	reported	report	VBN	VBN	_	19	amod	_	_
18	amino-terminal	amino-terminal	JJ	JJ	_	19	amod	_	_
19	sequence	sequence	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	bovine	bovine	JJ	JJ	_	22	amod	_	_
22	FKBP	fkbp	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	indicating	indicate	VBG	VBG	_	12	xcomp	_	_
25	that	that	IN	IN	_	30	mark	_	_
26	the	the	DT	DT	_	28	det	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	30	nsubj	_	_
29	isolated	isolate	VBN	VBN	_	28	acl	_	_
30	represents	represent	VBZ	VBZ	_	24	ccomp	_	_
31	the	the	DT	DT	_	32	det	_	_
32	gene	gene	NN	NN	_	30	dobj	_	_
33	coding	code	VBG	VBG	_	32	acl	_	_
34	for	for	IN	IN	_	35	case	_	_
35	FKBP	fkbp	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	12	punct	_	_

1	Computer-assisted	computer-assisted	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	deduced	deduce	VBN	VBN	_	8	amod	_	_
6	amino	amino	NN	NN	_	8	compound	_	_
7	acid	acid	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	2	nmod	_	_
9	indicates	indicate	VBZ	VBZ	_	0	root	_	_
10	that	that	IN	IN	_	12	mark	_	_
11	FKBP	fkbp	NN	NN	_	12	nsubj	_	_
12	exhibits	exhibit	VBZ	VBZ	_	9	ccomp	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	internal	internal	JJ	JJ	_	15	amod	_	_
15	homology	homology	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	does	do	VBZ	VBZ	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	have	have	VB	VB	_	12	conj	_	_
20	significant	significant	JJ	JJ	_	22	amod	_	_
21	sequence	sequence	NN	NN	_	22	compound	_	_
22	similarity	similarity	NN	NN	_	19	dobj	_	_
23	to	to	TO	TO	_	28	case	_	_
24	any	any	DT	DT	_	28	det	_	_
25	other	other	JJ	JJ	_	28	amod	_	_
26	amino	amino	NN	NN	_	28	compound	_	_
27	acid	acid	NN	NN	_	28	compound	_	_
28	sequences	sequence	NNS	NNS	_	22	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	known	known	JJ	JJ	_	31	amod	_	_
31	proteins	protein	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	including	include	VBG	VBG	_	34	case	_	_
34	cyclophilin	cyclophilin	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	two	two	CD	CD	_	8	nummod	_	_
6	catalytically	catalytically	RB	RB	_	7	advmod	_	_
7	similar	similar	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	14	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	cyclophilin	cyclophilin	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	FKBP	fkbp	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	evolved	evolve	VBD	VBD	_	3	ccomp	_	_
15	independently	independently	RB	RB	_	14	advmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	Northern	northern	NN	NN	_	4	compound	_	_
3	blot	blot	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	19	nmod	_	_
5	,	,	,	,	_	19	punct	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	species	species	NNS	NNS	_	19	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	approximately	approximately	RB	RB	_	10	advmod	_	_
10	1.8	1.8	CD	CD	_	11	nummod	_	_
11	kilobases	kilobase	NNS	NNS	_	7	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	hybridized	hybridize	VBD	VBD	_	7	acl:relcl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	FKBP	fkbp	NN	NN	_	17	compound	_	_
17	cDNA	cdna	NN	NN	_	13	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	detected	detect	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	poly(A)+	poly(a)+	JJ	JJ	_	22	amod	_	_
22	RNAs	rna	NNS	NNS	_	19	nmod	_	_
23	from	from	IN	IN	_	24	case	_	_
24	brain	brain	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	lung	lung	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	liver	liver	NN	NN	_	24	conj	_	_
29	,	,	,	,	_	24	punct	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	placental	placental	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	24	conj	_	_
33	and	and	CC	CC	_	24	cc	_	_
34	leukocytes	leukocyte	NNS	NNS	_	24	conj	_	_
35	.	.	.	.	_	19	punct	_	_

1	Induction	induction	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	Jurkat	jurkat	NN	NN	_	6	compound	_	_
4	leukemic	leukemic	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	12-myristate	12-myristate	NN	NN	_	10	compound	_	_
10	13-acetate	13-acetate	NN	NN	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	ionomycin	ionomycin	NN	NN	_	10	conj	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	affect	affect	VB	VB	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	level	level	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	FKBP	fkbp	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	Southern	southern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	genomic	genomic	JJ	JJ	_	7	amod	_	_
7	DNA	dna	NN	NN	_	3	nmod	_	_
8	digested	digest	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	restriction	restriction	NN	NN	_	12	compound	_	_
12	enzymes	enzyme	NNS	NNS	_	8	nmod	_	_
13	suggests	suggest	VBZ	VBZ	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	existence	existence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	only	only	RB	RB	_	19	advmod	_	_
18	a	a	DT	DT	_	19	advmod	_	_
19	few	few	JJ	JJ	_	20	nummod	_	_
20	copies	copy	NNS	NNS	_	15	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	20	nmod	_	_
25	encoding	encode	VBG	VBG	_	24	acl	_	_
26	FKBP	fkbp	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	in	in	IN	IN	_	4	case	_	_
4	contrast	contrast	NN	NN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	result	result	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	23	mark	_	_
9	as	as	RB	RB	_	12	advmod	_	_
10	many	many	JJ	JJ	_	12	advmod	_	_
11	as	as	IN	IN	_	12	advmod	_	_
12	20	20	CD	CD	_	13	nummod	_	_
13	copies	copy	NNS	NNS	_	23	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	dep	_	_
16	cyclophilin	cyclophilin	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	possible	possible	JJ	JJ	_	20	amod	_	_
20	pseudogenes	pseudogene	NNS	NNS	_	17	conj	_	_
21	may	may	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	present	present	JJ	JJ	_	7	ccomp	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	mammalian	mammalian	JJ	JJ	_	27	amod	_	_
27	genome	genome	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	The	the	DT	DT	_	4	det	_	_
3	inhibitory	inhibitory	JJ	JJ	_	4	amod	_	_
4	effect	effect	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	hydrocortisone	hydrocortisone	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	chemotactic	chemotactic	JJ	JJ	_	10	amod	_	_
10	migration	migration	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
14	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	Random	random	JJ	JJ	_	2	amod	_	_
2	migration	migration	NN	NN	_	20	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RM	rm	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	chemotactic	chemotactic	JJ	JJ	_	8	amod	_	_
8	migration	migration	NN	NN	_	2	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ChtM	chtm	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	of	of	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	yeast	yeast	NN	NN	_	18	compound	_	_
17	activated	activated	JJ	JJ	_	18	amod	_	_
18	serum	serum	NN	NN	_	2	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	studied	study	VBN	VBN	_	0	root	_	_
21	with	with	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	modified	modify	VBN	VBN	_	26	amod	_	_
24	Boyden	boyden	NN	NN	_	26	compound	_	_
25	chamber	chamber	NN	NN	_	26	compound	_	_
26	method	method	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	20	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	RM	rm	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	ChtM	chtm	NN	NN	_	2	conj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	circadian	circadian	JJ	JJ	_	7	amod	_	_
7	rhythm	rhythm	NN	NN	_	5	dobj	_	_
8	.	.	.	.	_	5	punct	_	_

1	Leukocytes	leukocyte	NNS	NNS	_	2	nsubj	_	_
2	migrated	migrate	VBD	VBD	_	0	root	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	rapidly	rapidly	RB	RB	_	2	advmod	_	_
5	at	at	IN	IN	_	6	case	_	_
6	night	night	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	24	nsubj	_	_
3	between	between	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	peak	peak	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	0	0	CD	CD	_	9	nummod	_	_
8	:	:	:	:	_	9	punct	_	_
9	00	00	CD	CD	_	5	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	trough	trough	NN	NN	_	13	compound	_	_
13	values	value	NNS	NNS	_	5	conj	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	8	8	CD	CD	_	17	nummod	_	_
16	:	:	:	:	_	17	punct	_	_
17	00	00	CD	CD	_	13	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	of	of	IN	IN	_	20	case	_	_
20	RM	rm	NN	NN	_	5	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	ChtM	chtm	NN	NN	_	20	conj	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	significant	significant	JJ	JJ	_	0	root	_	_
25	statistically	statistically	RB	RB	_	24	advmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	P	p	NN	NN	_	24	dep	_	_
28	less	less	JJR	JJR	_	27	amod	_	_
29	than	than	IN	IN	_	30	case	_	_
30	0.01	0.01	CD	CD	_	28	nmod	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	.	.	.	.	_	24	punct	_	_

1	ChtM	chtm	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	inhibited	inhibit	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	5	case	_	_
5	hydrocortisone	hydrocortisone	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	F	f	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	11	case	_	_
10	physiological	physiological	JJ	JJ	_	11	amod	_	_
11	concentration	concentration	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	10(-9)-10(-7)	10(-9)-10(-7)	CD	CD	_	14	nummod	_	_
14	mol/L	mol/l	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	5	acl:relcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	completely	completely	RB	RB	_	21	advmod	_	_
21	antagonized	antagonize	VBN	VBN	_	18	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	competitive	competitive	JJ	JJ	_	25	amod	_	_
25	antagonist	antagonist	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	RU38486	ru38486	NN	NN	_	25	appos	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	7	nsubj	_	_
4	was	be	VBD	VBD	_	7	cop	_	_
5	much	much	RB	RB	_	6	advmod	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	evident	evident	JJ	JJ	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	higher	higher	JJR	JJR	_	10	amod	_	_
10	dose	dose	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	more	more	JJR	JJR	_	14	advmod	_	_
13	than	than	IN	IN	_	12	mwe	_	_
14	10(-5)	10(-5)	CD	CD	_	15	nummod	_	_
15	mol/L	mol/l	NN	NN	_	10	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	it	it	PRP	PRP	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	reversed	reverse	VBN	VBN	_	7	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	RU38486	ru38486	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	but	but	CC	CC	_	21	cc	_	_
26	only	only	RB	RB	_	27	advmod	_	_
27	partially	partially	RB	RB	_	21	advmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	suggested	suggest	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	GC	gc	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	may	may	MD	MD	_	13	aux	_	_
10	be	be	VB	VB	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	physiological	physiological	JJ	JJ	_	13	amod	_	_
13	regulator	regulator	NN	NN	_	3	ccomp	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	leukocytes	leukocyte	NNS	NNS	_	16	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	inhibitory	inhibitory	JJ	JJ	_	22	amod	_	_
22	action	action	NN	NN	_	27	nsubjpass	_	_
23	on	on	IN	IN	_	24	case	_	_
24	ChtM	chtm	NN	NN	_	22	nmod	_	_
25	may	may	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	involved	involve	VBN	VBN	_	13	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	antiinflammatory	antiinflammatory	JJ	JJ	_	30	amod	_	_
30	mechanisms	mechanism	NNS	NNS	_	27	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	GC	gc	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	pharmacological	pharmacological	JJ	JJ	_	35	amod	_	_
35	doses	dose	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	action	action	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	physiological	physiological	JJ	JJ	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	pharmacological	pharmacological	JJ	JJ	_	4	conj	_	_
7	concentration	concentration	NN	NN	_	4	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GC	gc	NN	NN	_	4	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	18	case	_	_
14	low	low	JJ	JJ	_	18	amod	_	_
15	affinity	affinity	NN	NN	_	18	compound	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	12	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	56-59-kilodalton	56-59-kilodalton	JJ	JJ	_	3	amod	_	_
3	protein	protein	NN	NN	_	13	nsubj	_	_
4	identified	identify	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	9	case	_	_
6	untransformed	untransformed	JJ	JJ	_	9	amod	_	_
7	steroid	steroid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	complexes	complex	NNS	NNS	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	unique	unique	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	0	root	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	exists	exist	VBZ	VBZ	_	13	acl:relcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	cytosol	cytosol	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	complex	complex	NN	NN	_	15	nmod	_	_
21	with	with	IN	IN	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	70-	70-	CD	CD	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	90-kilodalton	90-kilodalton	JJ	JJ	_	24	conj	_	_
27	heat	heat	NN	NN	_	29	compound	_	_
28	shock	shock	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	24	dep	_	_
30	.	.	.	.	_	13	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	previously	previously	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	26	mark	_	_
7	9S	9s	NN	NN	_	26	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	untransformed	untransformed	JJ	JJ	_	10	amod	_	_
10	progestin	progestin	NN	NN	_	7	appos	_	_
11	,	,	,	,	_	10	punct	_	_
12	estrogen	estrogen	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	androgen	androgen	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	10	conj	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	complexes	complex	NNS	NNS	_	10	dep	_	_
20	in	in	IN	IN	_	21	case	_	_
21	rabbit	rabbit	NN	NN	_	7	nmod	_	_
22	uterine	uterine	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	liver	liver	NN	NN	_	21	conj	_	_
25	cytosols	cytosol	NNS	NNS	_	21	dep	_	_
26	contain	contain	VBP	VBP	_	5	ccomp	_	_
27	a	a	DT	DT	_	29	det	_	_
28	59-kDa	59-kda	JJ	JJ	_	29	amod	_	_
29	protein	protein	NN	NN	_	26	dobj	_	_
30	-LSB-	-lsb-	-LRB-	-LRB-	_	33	punct	_	_
31	Tai	Tai	NNP	NNP	_	33	compound	_	_
32	,	,	,	,	_	33	punct	_	_
33	P.K.	P.K.	NNP	NNP	_	5	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	Maeda	Maeda	NNP	NNP	_	37	compound	_	_
36	,	,	,	,	_	37	punct	_	_
37	Y.	Y.	NNP	NNP	_	33	conj	_	_
38	,	,	,	,	_	33	punct	_	_
39	Nakao	Nakao	NNP	NNP	_	41	compound	_	_
40	,	,	,	,	_	41	punct	_	_
41	K.	K.	NNP	NNP	_	33	conj	_	_
42	,	,	,	,	_	33	punct	_	_
43	Wakim	Wakim	NNP	NNP	_	45	compound	_	_
44	,	,	,	,	_	45	punct	_	_
45	N.G.	N.G.	NNP	NNP	_	33	conj	_	_
46	,	,	,	,	_	33	punct	_	_
47	Duhring	Duhring	NNP	NNP	_	49	compound	_	_
48	,	,	,	,	_	49	punct	_	_
49	J.L.	J.L.	NNP	NNP	_	33	conj	_	_
50	,	,	,	,	_	33	punct	_	_
51	&amp;	&amp;	CC	CC	_	33	cc	_	_
52	Faber	Faber	NNP	NNP	_	54	compound	_	_
53	,	,	,	,	_	54	punct	_	_
54	L.E.	L.E.	NNP	NNP	_	33	conj	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	1986	1986	CD	CD	_	58	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	Biochemistry	Biochemistry	NNP	NNP	_	33	dep	_	_
59	25	25	CD	CD	_	58	nummod	_	_
60	,	,	,	,	_	58	punct	_	_
61	5269-5275	5269-5275	CD	CD	_	58	nummod	_	_
62	-RSB-	-rsb-	-RRB-	-RRB-	_	33	punct	_	_
63	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	work	work	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	11	det	_	_
8	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
9	antibody	antibody	NN	NN	_	11	compound	_	_
10	KN	kn	NN	NN	_	11	compound	_	_
11	382/EC1	382/ec1	NN	NN	_	18	nsubj	_	_
12	raised	raise	VBN	VBN	_	11	acl	_	_
13	against	against	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	rabbit	rabbit	NN	NN	_	17	compound	_	_
16	59-kDa	59-kda	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	12	nmod	_	_
18	reacts	react	VBZ	VBZ	_	5	ccomp	_	_
19	with	with	IN	IN	_	20	case	_	_
20	9S	9s	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	untransformed	untransformed	JJ	JJ	_	25	amod	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	25	compound	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	complexes	complex	NNS	NNS	_	20	appos	_	_
26	in	in	IN	IN	_	27	case	_	_
27	cytosol	cytosol	NN	NN	_	25	nmod	_	_
28	prepared	prepare	VBN	VBN	_	27	acl	_	_
29	from	from	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	IM-9	im-9	NN	NN	_	32	compound	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
33	but	but	CC	CC	_	20	cc	_	_
34	not	not	RB	RB	_	38	neg	_	_
35	with	with	IN	IN	_	38	case	_	_
36	4S	4s	NN	NN	_	38	compound	_	_
37	salt-transformed	salt-transformed	JJ	JJ	_	38	amod	_	_
38	receptors	receptor	NNS	NNS	_	20	conj	_	_
39	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	protein	protein	NN	NN	_	12	nsubj	_	_
4	recognized	recognize	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	EC1	ec1	NN	NN	_	8	compound	_	_
8	antibody	antibody	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	56-kDa	56-kda	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	0	root	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	p56	p56	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	of	of	IN	IN	_	18	case	_	_
17	moderate	moderate	JJ	JJ	_	18	amod	_	_
18	abundance	abundance	NN	NN	_	12	nmod	_	_
19	located	located	JJ	JJ	_	12	amod	_	_
20	predominantly	predominantly	RB	RB	_	23	advmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	cytoplasm	cytoplasm	NN	NN	_	19	nmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	indirect	indirect	JJ	JJ	_	26	amod	_	_
26	immunofluorescence	immunofluorescence	NN	NN	_	12	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	are	be	VBP	VBP	_	0	root	_	_
3	at	at	IN	IN	_	4	case	_	_
4	least	least	JJS	JJS	_	5	nmod:npmod	_	_
5	six	six	CD	CD	_	6	nummod	_	_
6	isomorphs	isomorph	NNS	NNS	_	2	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p56	p56	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	two-dimensional	two-dimensional	JJ	JJ	_	12	amod	_	_
11	gel	gel	NN	NN	_	12	compound	_	_
12	analysis	analysis	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	N-Terminal	n-terminal	JJ	JJ	_	2	amod	_	_
2	sequencing	sequencing	NN	NN	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	20	20	CD	CD	_	6	nummod	_	_
5	amino	amino	NN	NN	_	6	compound	_	_
6	acids	acid	NNS	NNS	_	2	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	shows	show	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	p56	p56	NN	NN	_	15	nsubj	_	_
11	is	be	VBZ	VBZ	_	15	cop	_	_
12	a	a	DT	DT	_	15	det	_	_
13	unique	unique	JJ	JJ	_	15	amod	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	8	ccomp	_	_
16	.	.	.	.	_	8	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	p56	p56	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	immunoadsorbed	immunoadsorb	VBN	VBN	_	19	advcl	_	_
5	from	from	IN	IN	_	8	case	_	_
6	IM-9	im-9	NN	NN	_	7	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	cytosol	cytosol	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	19	punct	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	the	the	DT	DT	_	12	dep	_	_
12	70-	70-	CD	CD	_	19	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	90-kDa	90-kda	JJ	JJ	_	12	conj	_	_
15	heat	heat	NN	NN	_	17	compound	_	_
16	shock	shock	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	12	dep	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	coadsorbed	coadsorb	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	immune-specific	immune-specific	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	Neither	neither	DT	DT	_	4	dep	_	_
2	heat	heat	NN	NN	_	4	compound	_	_
3	shock	shock	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	reacts	react	VBZ	VBZ	_	0	root	_	_
6	directly	directly	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	EC1	ec1	NN	NN	_	10	compound	_	_
10	antibody	antibody	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	p56	p56	NN	NN	_	5	nsubj	_	_
5	exists	exist	VBZ	VBZ	_	2	ccomp	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cytosol	cytosol	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	higher	higher	JJR	JJR	_	12	amod	_	_
11	order	order	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	5	nmod	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	hsp70	hsp70	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	hsp90	hsp90	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	both	both	DT	DT	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	turn	turn	NN	NN	_	25	nmod	_	_
23	have	have	VBP	VBP	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	found	find	VBN	VBN	_	14	acl:relcl	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	associated	associate	VBN	VBN	_	25	xcomp	_	_
29	with	with	IN	IN	_	32	case	_	_
30	untransformed	untransformed	JJ	JJ	_	32	amod	_	_
31	steroid	steroid	NN	NN	_	32	compound	_	_
32	receptors	receptor	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	novel	novel	JJ	JJ	_	6	amod	_	_
3	B-cell	b-cell	NN	NN	_	6	compound	_	_
4	lineage-specific	lineage-specific	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	0	root	_	_
7	present	present	JJ	JJ	_	6	amod	_	_
8	at	at	IN	IN	_	9	case	_	_
9	early	early	JJ	JJ	_	7	nmod	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	late	late	JJ	JJ	_	9	conj	_	_
13	stages	stage	NNS	NNS	_	9	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	B-cell-specific	b-cell-specific	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	10	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	BSAP	bsap	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	as	as	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	mammalian	mammalian	JJ	JJ	_	14	amod	_	_
14	homolog	homolog	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	sea	sea	NN	NN	_	19	compound	_	_
18	urchin	urchin	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	14	nmod	_	_
20	TSAP	tsap	NN	NN	_	19	dep	_	_
21	,	,	,	,	_	19	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	interacts	interact	VBZ	VBZ	_	19	acl:relcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	promoters	promoter	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	four	four	CD	CD	_	31	nummod	_	_
29	tissue-specific	tissue-specific	JJ	JJ	_	31	amod	_	_
30	late	late	JJ	JJ	_	31	amod	_	_
31	histone	histone	NN	NN	_	26	nmod	_	_
32	H2A-2	h2a-2	NN	NN	_	31	dep	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	H2B-2	h2b-2	NN	NN	_	31	conj	_	_
35	genes	gene	NNS	NNS	_	31	dep	_	_
36	.	.	.	.	_	10	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	shown	show	VBN	VBN	_	17	advcl	_	_
3	by	by	IN	IN	_	4	case	_	_
4	mobility-shift	mobility-shift	JJ	JJ	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	methylation	methylation	NN	NN	_	7	compound	_	_
7	interference	interference	NN	NN	_	4	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	mutational	mutational	JJ	JJ	_	4	conj	_	_
11	analyses	analysis	NNS	NNS	_	4	dep	_	_
12	,	,	,	,	_	17	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	mammalian	mammalian	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	17	nsubj	_	_
16	BSAP	bsap	NN	NN	_	15	dep	_	_
17	recognizes	recognize	VBZ	VBZ	_	0	root	_	_
18	all	all	DT	DT	_	23	det	_	_
19	four	four	CD	CD	_	23	nummod	_	_
20	sea	sea	NN	NN	_	23	compound	_	_
21	urchin	urchin	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	17	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	manner	manner	NN	NN	_	17	nmod	_	_
27	indistinguishable	indistinguishable	JJ	JJ	_	26	amod	_	_
28	from	from	IN	IN	_	29	case	_	_
29	TSAP	tsap	NN	NN	_	27	nmod	_	_
30	;	;	:	:	_	17	punct	_	_
31	however	however	RB	RB	_	36	advmod	_	_
32	,	,	,	,	_	36	punct	_	_
33	the	the	DT	DT	_	35	det	_	_
34	two	two	CD	CD	_	35	nummod	_	_
35	proteins	protein	NNS	NNS	_	36	nsubj	_	_
36	differ	differ	VBP	VBP	_	17	parataxis	_	_
37	in	in	IN	IN	_	39	case	_	_
38	molecular	molecular	JJ	JJ	_	39	amod	_	_
39	weight	weight	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	17	punct	_	_

1	BSAP	bsap	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	exclusively	exclusively	RB	RB	_	4	advmod	_	_
4	restricted	restricted	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	lineage	lineage	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	activated	activate	VBN	VBN	_	3	xcomp	_	_
7	during	during	IN	IN	_	9	case	_	_
8	pro-B-cell	pro-b-cell	JJ	JJ	_	9	amod	_	_
9	development	development	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	abundant	abundant	JJ	JJ	_	3	dep	_	_
13	at	at	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	pre-B-	pre-b-	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mature	mature	JJ	JJ	_	18	amod	_	_
18	B-cell	b-cell	NN	NN	_	15	conj	_	_
19	stages	stage	NNS	NNS	_	15	dep	_	_
20	,	,	,	,	_	12	punct	_	_
21	but	but	CC	CC	_	12	cc	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	absent	absent	JJ	JJ	_	12	conj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	terminally	terminally	RB	RB	_	28	advmod	_	_
26	differentiated	differentiate	VBN	VBN	_	28	amod	_	_
27	plasma	plasma	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	BSAP	bsap	NN	NN	_	9	nsubj	_	_
4	is	be	VBZ	VBZ	_	9	cop	_	_
5	clearly	clearly	RB	RB	_	9	advmod	_	_
6	a	a	DT	DT	_	9	det	_	_
7	B-cell-specific	b-cell-specific	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	wild-type	wild-type	JJ	JJ	_	9	nmod	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	13	cc	_	_
16	a	a	DT	DT	_	19	det	_	_
17	mutant	mutant	JJ	JJ	_	19	amod	_	_
18	TSAP-binding	tsap-binding	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	13	conj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	sea	sea	NN	NN	_	24	compound	_	_
23	urchin	urchin	NN	NN	_	24	compound	_	_
24	functions	function	NNS	NNS	_	13	nmod	_	_
25	only	only	RB	RB	_	29	advmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	transfected	transfect	VBN	VBN	_	29	amod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	as	as	IN	IN	_	34	case	_	_
31	an	a	DT	DT	_	34	det	_	_
32	upstream	upstream	JJ	JJ	_	34	amod	_	_
33	promoter	promoter	NN	NN	_	34	compound	_	_
34	element	element	NN	NN	_	9	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	Competition	competition	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	reveal	reveal	VB	VB	_	0	root	_	_
6	any	any	DT	DT	_	9	det	_	_
7	high-affinity	high-affinity	JJ	JJ	_	9	amod	_	_
8	binding	bind	VBG	VBG	_	9	amod	_	_
9	site	site	NN	NN	_	5	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	BSAP	bsap	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	known	known	JJ	JJ	_	15	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	regions	region	NNS	NNS	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	immunoglobulin	immunoglobulin	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	class	class	NN	NN	_	22	compound	_	_
20	II	ii	CD	CD	_	22	nummod	_	_
21	major	major	JJ	JJ	_	22	amod	_	_
22	histocompatibility	histocompatibility	NN	NN	_	17	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	MHC	mhc	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	genes	gene	NNS	NNS	_	17	dep	_	_
27	,	,	,	,	_	5	punct	_	_
28	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
29	that	that	IN	IN	_	33	mark	_	_
30	BSAP	bsap	NN	NN	_	33	nsubj	_	_
31	is	be	VBZ	VBZ	_	33	cop	_	_
32	a	a	DT	DT	_	33	det	_	_
33	regulator	regulator	NN	NN	_	28	ccomp	_	_
34	of	of	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	different	different	JJ	JJ	_	37	amod	_	_
37	set	set	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	B-lymphoid-specific	b-lymphoid-specific	JJ	JJ	_	40	amod	_	_
40	genes	gene	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	Tandem	tandem	JJ	JJ	_	3	amod	_	_
2	AP-1-binding	ap-1-binding	JJ	JJ	_	3	amod	_	_
3	sites	site	NNS	NNS	_	11	nsubj	_	_
4	within	within	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	beta-globin	beta-globin	NN	NN	_	10	compound	_	_
8	dominant	dominant	JJ	JJ	_	10	amod	_	_
9	control	control	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	3	nmod	_	_
11	function	function	VBP	VBP	_	0	root	_	_
12	as	as	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	inducible	inducible	JJ	JJ	_	15	amod	_	_
15	enhancer	enhancer	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	powerful	powerful	JJ	JJ	_	3	amod	_	_
3	enhancer	enhancer	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	mapped	map	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	18-bp	18-bp	JJ	JJ	_	11	amod	_	_
10	DNA	dna	NN	NN	_	11	compound	_	_
11	segment	segment	NN	NN	_	6	nmod	_	_
12	located	located	JJ	JJ	_	11	amod	_	_
13	11	11	CD	CD	_	14	nummod	_	_
14	kb	kb	NN	NN	_	12	nmod	_	_
15	5'	5'	JJ	JJ	_	14	amod	_	_
16	to	to	TO	TO	_	14	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	epsilon-globin	epsilon-globin	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	14	dep	_	_
21	within	within	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	dep	_	_
23	dominant	dominant	JJ	JJ	_	24	amod	_	_
24	control	control	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	locus-activating	locus-activating	JJ	JJ	_	27	amod	_	_
27	region	region	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	inducible	inducible	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	K562	k562	NN	NN	_	9	compound	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	erythroleukemia	erythroleukemia	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	increasing	increase	VBG	VBG	_	4	xcomp	_	_
12	linked	link	VBN	VBN	_	16	amod	_	_
13	gamma-globin	gamma-globin	NN	NN	_	14	compound	_	_
14	promoter/luciferase	promoter/luciferase	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	11	dobj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	170-fold	170-fold	RB	RB	_	11	nmod	_	_
19	over	over	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	enhancerless	enhancerless	JJ	JJ	_	22	amod	_	_
22	construct	construct	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	3	nsubj	_	_
3	consists	consist	VBZ	VBZ	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	tandem	tandem	JJ	JJ	_	7	amod	_	_
6	AP-1-binding	ap-1-binding	JJ	JJ	_	7	amod	_	_
7	sites	site	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	phased	phased	JJ	JJ	_	7	amod	_	_
10	10	10	CD	CD	_	11	nummod	_	_
11	bp	bp	NN	NN	_	12	nmod:npmod	_	_
12	apart	apart	RB	RB	_	9	advmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	which	which	WDT	WDT	_	17	nsubjpass	_	_
15	are	be	VBP	VBP	_	17	auxpass	_	_
16	both	both	DT	DT	_	17	dep	_	_
17	required	require	VBN	VBN	_	7	acl:relcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	full	full	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	DNA-protein	dna-protein	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	10	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	induced	induce	VBN	VBN	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	high	high	JJ	JJ	_	15	amod	_	_
13	molecular	molecular	JJ	JJ	_	15	amod	_	_
14	weight	weight	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	10	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	enhancer	enhancer	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	formation	formation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	complex	complex	NN	NN	_	2	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	both	both	DT	DT	_	10	dep	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	7	dobj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	correlates	correlate	VBZ	VBZ	_	7	conj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	maximal	maximal	JJ	JJ	_	16	amod	_	_
15	enhancer	enhancer	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Induction	induction	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	enhancer	enhancer	NN	NN	_	1	nmod	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	have	have	VB	VB	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	increase	increase	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	globin	globin	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	characterizes	characterize	VBZ	VBZ	_	15	acl:relcl	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	maturation	maturation	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Enhancer	enhancer	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	3	xcomp	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	binding	binding	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	complex	complex	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	proteins	protein	NNS	NNS	_	12	nmod	_	_
15	from	from	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	jun	jun	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	fos	fos	NN	NN	_	17	conj	_	_
20	families	family	NNS	NNS	_	14	nmod	_	_
21	to	to	TO	TO	_	25	case	_	_
22	tandem	tandem	JJ	JJ	_	25	amod	_	_
23	AP-1	ap-1	NN	NN	_	25	compound	_	_
24	consensus	consensus	NN	NN	_	25	compound	_	_
25	sequences	sequence	NNS	NNS	_	9	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	non-erythroid	non-erythroid	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	factor	factor	NN	NN	_	1	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	characteristics	characteristic	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	11	nmod	_	_
18	EF1	ef1	NN	NN	_	17	dep	_	_
19	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	10	nsubj	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	factor-1	factor-1	NN	NN	_	4	dep	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EF1	ef1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	plays	play	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	critical	critical	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	transcription	transcription	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	erythroid-specific	erythroid-specific	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	mobility	mobility	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sequence-specific	sequence-specific	JJ	JJ	_	15	amod	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	characteristics	characteristic	NNS	NNS	_	11	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	EF1	ef1	NN	NN	_	11	nmod	_	_
18	at	at	IN	IN	_	20	case	_	_
19	low	low	JJ	JJ	_	20	amod	_	_
20	abundance	abundance	NN	NN	_	8	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	wide	wide	JJ	JJ	_	24	amod	_	_
24	variety	variety	NN	NN	_	8	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	non-erythroid	non-erythroid	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	types	type	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	report	report	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	EF1-like	ef1-like	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	non-erythroid	non-erythroid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	indicates	indicate	VBZ	VBZ	_	5	conj	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	factor	factor	NN	NN	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	play	play	VB	VB	_	14	ccomp	_	_
20	a	a	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	regulation	regulation	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	genes	gene	NNS	NNS	_	24	nmod	_	_
27	expressed	express	VBN	VBN	_	26	acl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	such	such	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	3,5,3'-triiodothyronine	3,5,3'-triiodothyronine	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	T3R	t3r	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	of	of	IN	IN	_	10	case	_	_
8	circulating	circulate	VBG	VBG	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	hyper-	hyper-	JJ	JJ	_	3	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	hypothyroidism	hypothyroidism	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	nonthyroidal	nonthyroidal	JJ	JJ	_	17	amod	_	_
17	diseases	disease	NNS	NNS	_	12	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	implications	implication	NNS	NNS	_	19	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	T3R	t3r	NN	NN	_	7	compound	_	_
7	alterations	alteration	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	circulating	circulate	VBG	VBG	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	hyperthyroidism	hyperthyroidism	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	hypothyroidism	hypothyroidism	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	nonthyroidal	nonthyroidal	JJ	JJ	_	17	amod	_	_
17	diseases	disease	NNS	NNS	_	12	conj	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	investigated	investigate	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	T3R	t3r	NN	NN	_	6	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	determined	determine	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	radio-ligand	radio-ligand	JJ	JJ	_	10	amod	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	analysis	analysis	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	hyper-	hyper-	JJ	JJ	_	19	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	hypothyroid	hypothyroid	JJ	JJ	_	6	conj	_	_
9	patients	patient	NNS	NNS	_	6	dep	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	affinity	affinity	NN	NN	_	19	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	Ka	ka	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	for	for	IN	IN	_	17	case	_	_
17	T3	t3	NN	NN	_	12	nmod	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	similar	similar	JJ	JJ	_	3	ccomp	_	_
20	to	to	TO	TO	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	subjects	subject	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	hyperthyroidism	hyperthyroidism	NN	NN	_	12	nmod	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	T3	t3	NN	NN	_	12	nsubj	_	_
5	maximal	maximal	JJ	JJ	_	7	amod	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	capacity	capacity	NN	NN	_	4	dep	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MBC	mbc	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	unaltered	unaltered	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	whereas	whereas	IN	IN	_	21	mark	_	_
15	in	in	IN	IN	_	16	case	_	_
16	hypothyroidism	hypothyroidism	NN	NN	_	21	nmod	_	_
17	the	the	DT	DT	_	18	det	_	_
18	MBC	mbc	NN	NN	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	significantly	significantly	RB	RB	_	21	advmod	_	_
21	increased	increase	VBN	VBN	_	12	advcl	_	_
22	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	patients	patient	NNS	NNS	_	24	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	diabetes	diabetes	NN	NN	_	6	compound	_	_
6	mellitus	mellitus	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	chronic	chronic	JJ	JJ	_	10	amod	_	_
9	renal	renal	JJ	JJ	_	10	amod	_	_
10	failure	failure	NN	NN	_	6	conj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	hepatic	hepatic	JJ	JJ	_	13	amod	_	_
13	cirrhosis	cirrhosis	NN	NN	_	6	conj	_	_
14	,	,	,	,	_	24	punct	_	_
15	the	the	DT	DT	_	18	det	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	T3R	t3r	NN	NN	_	18	compound	_	_
18	MBC	mbc	NN	NN	_	24	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
21	was	be	VBD	VBD	_	24	cop	_	_
22	about	about	RB	RB	_	24	advmod	_	_
23	1.5-1.6	1.5-1.6	CD	CD	_	24	compound	_	_
24	times	time	NNS	NNS	_	0	root	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	controls	control	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	24	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	existed	exist	VBD	VBD	_	3	ccomp	_	_
7	hormonal	hormonal	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	T3R	t3r	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	up-regulation	up-regulation	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	seen	see	VBN	VBN	_	6	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	hypothyroidism	hypothyroidism	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	low	low	JJ	JJ	_	22	amod	_	_
21	T3	t3	NN	NN	_	22	compound	_	_
22	syndrome	syndrome	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	type	type	NN	NN	_	3	compound	_	_
3	specificity	specificity	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	requirements	requirement	NNS	NNS	_	3	conj	_	_
7	for	for	IN	IN	_	17	case	_	_
8	NFAT-1	nfat-1	NN	NN	_	17	compound	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	8	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	activated	activate	VBN	VBN	_	14	amod	_	_
14	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
15	)	)	-RRB-	-RRB-	_	11	punct	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	3	nmod	_	_
18	determined	determine	VBN	VBN	_	3	acl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	new	new	JJ	JJ	_	22	amod	_	_
22	method	method	NN	NN	_	18	nmod	_	_
23	using	use	VBG	VBG	_	22	acl	_	_
24	transgenic	transgenic	JJ	JJ	_	25	amod	_	_
25	mice	mouse	NNS	NNS	_	23	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	assay	assay	VB	VB	_	23	advcl	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	an	a	DT	DT	_	34	det	_	_
32	individual	individual	JJ	JJ	_	34	amod	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	activated	activate	VBN	VBN	_	5	amod	_	_
5	T-cells	t-cell	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	NFAT-1	nfat-1	NN	NN	_	2	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	0	root	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	considered	consider	VBN	VBN	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	20	mark	_	_
17	be	be	VB	VB	_	20	cop	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	regulator	regulator	NN	NN	_	15	xcomp	_	_
21	in	in	IN	IN	_	24	case	_	_
22	early	early	JJ	JJ	_	24	amod	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	system	system	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	monitor	monitor	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFAT-1	nfat-1	NN	NN	_	10	nmod	_	_
13	at	at	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	single	single	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	level	level	NN	NN	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	whole	whole	JJ	JJ	_	20	amod	_	_
20	animals	animal	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	system	system	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	based	base	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	an	a	DT	DT	_	13	det	_	_
10	oligomerized	oligomerized	JJ	JJ	_	13	amod	_	_
11	NFAT-1	nfat-1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	motif	motif	NN	NN	_	7	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	directs	direct	VBZ	VBZ	_	13	acl:relcl	_	_
16	transcription	transcription	NN	NN	_	19	compound	_	_
17	of	of	IN	IN	_	19	amod	_	_
18	SV40	sv40	NN	NN	_	19	compound	_	_
19	T-antigen	t-antigen	NN	NN	_	15	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	transgenic	transgenic	JJ	JJ	_	22	amod	_	_
22	mice	mouse	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	3	nsubj	_	_
3	represents	represent	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	demonstration	demonstration	NN	NN	_	3	dobj	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	a	a	DT	DT	_	12	det	_	_
9	multimerized	multimerized	JJ	JJ	_	12	amod	_	_
10	short	short	JJ	JJ	_	12	amod	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	motif	motif	NN	NN	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	function	function	VB	VB	_	6	ccomp	_	_
15	appropriately	appropriately	RB	RB	_	14	advmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	transgenic	transgenic	JJ	JJ	_	18	amod	_	_
18	mice	mouse	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	NFAT-1	nfat-1	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	6	nsubjpass	_	_
3	had	have	VBD	VBD	_	6	aux	_	_
4	previously	previously	RB	RB	_	6	advmod	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	thought	think	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	confined	confine	VBN	VBN	_	6	xcomp	_	_
10	to	to	TO	TO	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	nmod	_	_
13	upon	upon	IN	IN	_	14	case	_	_
14	release	release	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
17	calcium	calcium	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	targeting	target	VBG	VBG	_	10	advcl	_	_
3	NFAT-1-dependent	nfat-1-dependent	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	5	nmod	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	discovered	discover	VBD	VBD	_	0	root	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NFAT-1	nfat-1	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Besides	besides	IN	IN	_	3	case	_	_
2	in	in	IN	IN	_	3	case	_	_
3	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	nmod	_	_
4	NFAT-1	nfat-1	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	9	nsubjpass	_	_
6	could	could	MD	MD	_	9	aux	_	_
7	also	also	RB	RB	_	9	advmod	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	T-lymphocyte-depleted	t-lymphocyte-depleted	JJ	JJ	_	13	amod	_	_
12	spleen	spleen	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	purified	purify	VBN	VBN	_	16	amod	_	_
16	B-lymphocytes	b-lymphocyte	NNS	NNS	_	13	conj	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	requires	require	VBZ	VBZ	_	9	conj	_	_
19	agents	agent	NNS	NNS	_	18	dobj	_	_
20	that	that	WDT	WDT	_	22	nsubj	_	_
21	both	both	CC	CC	_	22	dep	_	_
22	release	release	VBP	VBP	_	19	acl:relcl	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	calcium	calcium	NN	NN	_	22	dobj	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	activate	activate	VBP	VBP	_	22	conj	_	_
27	protein	protein	NN	NN	_	29	compound	_	_
28	kinase	kinase	NN	NN	_	29	compound	_	_
29	C	c	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	17	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	time	time	NN	NN	_	6	compound	_	_
6	course	course	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	appearance	appearance	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NFAT-1	nfat-1	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	T-lymphocytes	t-lymphocyte	NNS	NNS	_	2	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	non-T-lymphocytes	non-t-lymphocyte	NNS	NNS	_	13	conj	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	revealed	reveal	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	small	small	JJ	JJ	_	8	amod	_	_
8	population	population	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	cells	cell	NNS	NNS	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	dermis	dermis	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	some	some	DT	DT	_	16	det	_	_
16	mice	mouse	NNS	NNS	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	developed	develop	VBN	VBN	_	4	conj	_	_
19	skin	skin	NN	NN	_	20	compound	_	_
20	lesions	lesion	NNS	NNS	_	18	dobj	_	_
21	.	.	.	.	_	4	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tissue	tissue	NN	NN	_	5	compound	_	_
5	pattern	pattern	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	expression	expression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NFAT-1	nfat-1	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	resembles	resemble	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	pattern	pattern	NN	NN	_	12	xcomp	_	_
16	described	describe	VBN	VBN	_	15	acl	_	_
17	for	for	IN	IN	_	20	case	_	_
18	HIV-LTR/tat	hiv-ltr/tat	NN	NN	_	20	compound	_	_
19	transgenic	transgenic	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	Vogel	Vogel	NNP	NNP	_	24	compound	_	_
23	,	,	,	,	_	24	punct	_	_
24	J.	J.	NNP	NNP	_	12	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	Hinrichs	Hinrichs	NNP	NNP	_	29	compound	_	_
27	,	,	,	,	_	29	punct	_	_
28	S.	S.	NNP	NNP	_	29	appos	_	_
29	H.	H.	NNP	NNP	_	24	conj	_	_
30	,	,	,	,	_	24	punct	_	_
31	Reynolds	Reynolds	NNP	NNP	_	34	compound	_	_
32	,	,	,	,	_	34	punct	_	_
33	R.	R.	NNP	NNP	_	34	appos	_	_
34	K.	K.	NNP	NNP	_	24	conj	_	_
35	,	,	,	,	_	24	punct	_	_
36	Luciw	Luciw	NNP	NNP	_	39	compound	_	_
37	,	,	,	,	_	39	punct	_	_
38	P.	P.	NNP	NNP	_	39	appos	_	_
39	A.	A.	NNP	NNP	_	24	conj	_	_
40	,	,	,	,	_	24	punct	_	_
41	and	and	CC	CC	_	24	cc	_	_
42	Jay	Jay	NNP	NNP	_	44	compound	_	_
43	,	,	,	,	_	44	punct	_	_
44	G.	G.	NNP	NNP	_	24	conj	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	1988	1988	CD	CD	_	24	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	Nature	Nature	NNP	NNP	_	24	dep	_	_
49	335	335	CD	CD	_	48	nummod	_	_
50	,	,	,	,	_	48	punct	_	_
51	606-611	606-611	CD	CD	_	48	amod	_	_
52	)	)	-RRB-	-RRB-	_	24	punct	_	_
53	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	similarity	similarity	NN	NN	_	19	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	expression	expression	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	fact	fact	NN	NN	_	2	conj	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	NFAT-1	nfat-1	NN	NN	_	12	nsubjpass	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	7	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	bind	bind	VB	VB	_	12	xcomp	_	_
15	functional	functional	JJ	JJ	_	16	amod	_	_
16	sequences	sequence	NNS	NNS	_	14	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	HIV-LTR	hiv-ltr	NN	NN	_	14	nmod	_	_
19	suggest	suggest	VBP	VBP	_	0	root	_	_
20	a	a	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	NFAT-1	nfat-1	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	dermal	dermal	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	HIV-LTR	hiv-ltr	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	19	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	immediate	immediate	JJ	JJ	_	6	amod	_	_
4	early	early	JJ	JJ	_	6	amod	_	_
5	response	response	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	1	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	macrophage	macrophage	NN	NN	_	10	compound	_	_
9	colony-stimulating	colony-stimulating	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	normal	normal	JJ	JJ	_	14	amod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	group	group	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	coordinately	coordinately	RB	RB	_	6	advmod	_	_
5	induced	induce	VBN	VBN	_	6	amod	_	_
6	protooncogenes	protooncogene	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	cytoskeletal	cytoskeletal	JJ	JJ	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	extracellular	extracellular	JJ	JJ	_	8	conj	_	_
12	matrix	matrix	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	8	dep	_	_
14	have	have	VBP	VBP	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	termed	term	VBN	VBN	_	0	root	_	_
17	immediate	immediate	JJ	JJ	_	20	amod	_	_
18	early	early	JJ	JJ	_	20	amod	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	16	xcomp	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	induction	induction	NN	NN	_	27	nsubjpass	_	_
25	has	have	VBZ	VBZ	_	27	aux	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	associated	associate	VBN	VBN	_	16	conj	_	_
28	with	with	IN	IN	_	32	case	_	_
29	growth	growth	NN	NN	_	32	compound	_	_
30	factor-stimulated	factor-stimulated	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	proliferation	proliferation	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	induction	induction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	macrophage-CSF	macrophage-csf	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	M-CSF	m-csf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
17	that	that	WDT	WDT	_	20	nsubj	_	_
18	do	do	VBP	VBP	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	proliferate	proliferate	VB	VB	_	3	dep	_	_
21	in	in	IN	IN	_	22	case	_	_
22	response	response	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	M-CSF	m-csf	NN	NN	_	22	nmod	_	_
25	but	but	CC	CC	_	20	cc	_	_
26	require	require	VBP	VBP	_	20	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	factor	factor	NN	NN	_	26	dobj	_	_
29	for	for	IN	IN	_	32	case	_	_
30	optimal	optimal	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	differentiation	differentiation	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Normal	normal	JJ	JJ	_	3	amod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	isolated	isolate	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	carefully	carefully	RB	RB	_	8	advmod	_	_
8	washed	wash	VBN	VBN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	incubated	incubate	VBN	VBN	_	5	conj	_	_
12	for	for	IN	IN	_	16	case	_	_
13	36	36	CD	CD	_	15	compound	_	_
14	to	to	TO	TO	_	15	dep	_	_
15	48	48	CD	CD	_	16	nummod	_	_
16	h	h	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	fetal	fetal	JJ	JJ	_	21	amod	_	_
19	bovine	bovine	NN	NN	_	21	compound	_	_
20	serum-containing	serum-containing	JJ	JJ	_	21	amod	_	_
21	medium	medium	NN	NN	_	11	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	end	end	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	incubation	incubation	NN	NN	_	3	nmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	resting	rest	VBG	VBG	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	stimulated	stimulate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	M-CSF	m-csf	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	RNA	rna	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	isolated	isolate	VBN	VBN	_	11	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	analysis	analysis	NN	NN	_	18	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	Northern	northern	JJ	JJ	_	23	amod	_	_
23	blotting	blotting	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	RNA	rna	NN	NN	_	6	nsubj	_	_
2	from	from	IN	IN	_	5	case	_	_
3	control	control	JJ	JJ	_	5	amod	_	_
4	resting	rest	VBG	VBG	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	low	low	JJ	JJ	_	6	dobj	_	_
8	to	to	TO	TO	_	9	case	_	_
9	undetectable	undetectable	JJ	JJ	_	7	nmod	_	_
10	levels	level	NNS	NNS	_	9	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	c-jun	c-jun	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	fibronectin	fibronectin	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	actin	actin	NN	NN	_	19	compound	_	_
19	mRNA	mrna	NN	NN	_	12	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Within	within	IN	IN	_	5	case	_	_
2	15	15	CD	CD	_	4	compound	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	30	30	CD	CD	_	5	nummod	_	_
5	min	min	NN	NN	_	14	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	addition	addition	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	M-CSF	m-csf	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	however	however	RB	RB	_	14	advmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	there	there	EX	EX	_	14	expl	_	_
14	was	be	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	18	det	_	_
16	dramatic	dramatic	JJ	JJ	_	18	amod	_	_
17	coordinate	coordinate	JJ	JJ	_	18	amod	_	_
18	induction	induction	NN	NN	_	14	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	genes	gene	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	c-jun	c-jun	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	7	nsubj	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	very	very	RB	RB	_	7	advmod	_	_
7	transient	transient	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	detectable	detectable	JJ	JJ	_	7	conj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	60	60	CD	CD	_	14	nummod	_	_
14	min	min	NN	NN	_	11	nmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	M-CSF	m-csf	NN	NN	_	17	compound	_	_
17	addition	addition	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	14	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	actin	actin	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	fibronectin	fibronectin	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	7	conj	_	_
11	mRNA	mrna	NN	NN	_	7	dep	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	more	more	RBR	RBR	_	14	advmod	_	_
14	sustained	sustain	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	22	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	genes	gene	NNS	NNS	_	18	nmod	_	_
22	remained	remain	VBD	VBD	_	14	conj	_	_
23	elevated	elevated	JJ	JJ	_	22	xcomp	_	_
24	at	at	IN	IN	_	28	case	_	_
25	24	24	CD	CD	_	27	compound	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	48	48	CD	CD	_	28	nummod	_	_
28	h	h	NN	NN	_	23	nmod	_	_
29	after	after	IN	IN	_	31	case	_	_
30	M-CSF	m-csf	NN	NN	_	31	compound	_	_
31	addition	addition	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	induction	induction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	myelomonocytic	myelomonocytic	JJ	JJ	_	13	amod	_	_
9	specific	specific	JJ	JJ	_	13	amod	_	_
10	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
11	kinase	kinase	NN	NN	_	13	compound	_	_
12	hck	hck	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	5	nmod	_	_
14	simultaneously	simultaneously	RB	RB	_	5	advmod	_	_
15	with	with	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	other	other	JJ	JJ	_	21	amod	_	_
18	immediate	immediate	JJ	JJ	_	21	amod	_	_
19	early	early	JJ	JJ	_	21	amod	_	_
20	response	response	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	5	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	protein	protein	NN	NN	_	5	compound	_	_
3	synthesis	synthesis	NN	NN	_	5	compound	_	_
4	inhibitor	inhibitor	NN	NN	_	5	compound	_	_
5	cycloheximide	cycloheximide	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	block	block	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	any	any	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	in	in	IN	IN	_	19	case	_	_
19	fact	fact	NN	NN	_	8	conj	_	_
20	,	,	,	,	_	8	punct	_	_
21	super-induced	super-induce	VBD	VBD	_	8	conj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	c-jun	c-jun	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	hck	hck	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	8	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	run	run	NN	NN	_	0	root	_	_
3	on	on	IN	IN	_	4	case	_	_
4	transcription	transcription	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	c-jun	c-jun	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	hck	hck	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	actin	actin	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	7	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	normal	normal	JJ	JJ	_	6	amod	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
7	M-CSF	m-csf	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	immediate	immediate	JJ	JJ	_	12	amod	_	_
10	early	early	JJ	JJ	_	12	amod	_	_
11	response	response	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	8	dobj	_	_
13	without	without	IN	IN	_	14	mark	_	_
14	inducing	induce	VBG	VBG	_	8	advcl	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	proliferation	proliferation	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	5	nsubj	_	_
3	may	may	MD	MD	_	5	aux	_	_
4	then	then	RB	RB	_	5	advmod	_	_
5	play	play	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	12	mark	_	_
9	altering	alter	VBG	VBG	_	12	amod	_	_
10	the	the	DT	DT	_	12	det	_	_
11	physiologic	physiologic	JJ	JJ	_	12	amod	_	_
12	status	status	NN	NN	_	5	advcl	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	12	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	CSF	csf	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Cell-specific	cell-specific	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
13	virus	virus	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	beta	beta	NN	NN	_	16	compound	_	_
16	interferon	interferon	NN	NN	_	13	conj	_	_
17	promoters	promoter	NNS	NNS	_	13	dep	_	_
18	by	by	IN	IN	_	21	case	_	_
19	tumor	tumor	NN	NN	_	21	compound	_	_
20	necrosis	necrosis	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	4	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	aspects	aspect	NNS	NNS	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	tumor	tumor	NN	NN	_	9	compound	_	_
8	necrosis	necrosis	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	17	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
13	virus	virus	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HIV	hiv	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	pathogenesis	pathogenesis	NN	NN	_	2	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	examined	examine	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Tumor	tumor	NN	NN	_	9	compound	_	_
2	necrosis	necrosis	NN	NN	_	9	compound	_	_
3	factor	factor	NN	NN	_	9	compound	_	_
4	alpha	alpha	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	16	case	_	_
13	polymerase	polymerase	NN	NN	_	16	compound	_	_
14	chain	chain	NN	NN	_	16	compound	_	_
15	reaction	reaction	NN	NN	_	16	compound	_	_
16	amplification	amplification	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
19	U937	u937	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	11	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	in	in	IN	IN	_	29	case	_	_
23	a	a	DT	DT	_	29	det	_	_
24	chronically	chronically	RB	RB	_	29	advmod	_	_
25	HIV	hiv	NN	NN	_	29	compound	_	_
26	infected	infected	JJ	JJ	_	29	amod	_	_
27	U937	u937	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	20	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	U9-IIIB	u9-iiib	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	11	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	2	compound	_	_
2	RNA	rna	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	undetectable	undetectable	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	U937	u937	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	whereas	whereas	IN	IN	_	15	mark	_	_
10	a	a	DT	DT	_	13	det	_	_
11	low	low	JJ	JJ	_	13	amod	_	_
12	constitutive	constitutive	JJ	JJ	_	13	amod	_	_
13	level	level	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	detected	detect	VBN	VBN	_	4	advcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	U9-IIIB	u9-iiib	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Paramyxovirus	paramyxovirus	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	5-	5-	CD	CD	_	7	compound	_	_
6	to	to	TO	TO	_	7	dep	_	_
7	10-fold	10-fold	JJ	JJ	_	8	amod	_	_
8	increase	increase	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	steady-state	steady-state	JJ	JJ	_	12	amod	_	_
12	level	level	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
15	RNA	rna	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	U9-IIIB	u9-iiib	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	compared	compare	VBN	VBN	_	22	case	_	_
20	with	with	IN	IN	_	22	case	_	_
21	U937	u937	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	3	advcl	_	_
23	,	,	,	,	_	3	punct	_	_
24	suggesting	suggest	VBG	VBG	_	3	advcl	_	_
25	that	that	IN	IN	_	29	mark	_	_
26	HIV-infected	hiv-infected	JJ	JJ	_	28	amod	_	_
27	monocytic	monocytic	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	29	nsubj	_	_
29	produced	produce	VBD	VBD	_	24	ccomp	_	_
30	higher	higher	JJR	JJR	_	31	amod	_	_
31	levels	level	NNS	NNS	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	TNF-alpha	tnf-alpha	NN	NN	_	31	nmod	_	_
34	than	than	IN	IN	_	35	dep	_	_
35	did	do	VBD	VBD	_	29	advcl	_	_
36	normal	normal	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	35	nsubj	_	_
38	after	after	IN	IN	_	42	case	_	_
39	a	a	DT	DT	_	42	det	_	_
40	secondary	secondary	JJ	JJ	_	42	amod	_	_
41	virus	virus	NN	NN	_	42	compound	_	_
42	infection	infection	NN	NN	_	35	dep	_	_
43	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	examined	examine	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	transient	transient	JJ	JJ	_	13	amod	_	_
12	expression	expression	NN	NN	_	13	compound	_	_
13	assays	assay	NNS	NNS	_	9	nmod	_	_
14	using	use	VBG	VBG	_	13	acl	_	_
15	reporter	reporter	NN	NN	_	18	compound	_	_
16	chloramphenicol	chloramphenicol	NN	NN	_	18	compound	_	_
17	acetyltransferase	acetyltransferase	NN	NN	_	18	compound	_	_
18	plasmids	plasmid	NNS	NNS	_	14	dobj	_	_
19	linked	link	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	19	nmod	_	_
23	from	from	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	HIV	hiv	NN	NN	_	28	compound	_	_
26	long	long	JJ	JJ	_	28	amod	_	_
27	terminal	terminal	JJ	JJ	_	28	amod	_	_
28	repeat	repeat	NN	NN	_	22	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	LTR	ltr	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	the	the	DT	DT	_	36	det	_	_
34	beta	beta	NN	NN	_	36	compound	_	_
35	interferon	interferon	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	28	conj	_	_
37	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	U937	u937	NN	NN	_	21	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Jurkat	jurkat	NN	NN	_	5	compound	_	_
5	T	t	NN	NN	_	2	conj	_	_
6	lymphoid	lymphoid	JJ	JJ	_	5	amod	_	_
7	cells	cell	NNS	NNS	_	2	dep	_	_
8	,	,	,	,	_	21	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	inducibility	inducibility	NN	NN	_	21	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	hybrid	hybrid	NN	NN	_	15	compound	_	_
15	promoters	promoter	NNS	NNS	_	10	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	10	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	phorbol	phorbol	NN	NN	_	20	compound	_	_
20	ester	ester	NN	NN	_	17	conj	_	_
21	varied	vary	VBD	VBD	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	dep	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	type-	type-	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	promoter	promoter	NN	NN	_	28	nmod:npmod	_	_
28	context-specific	context-specific	JJ	JJ	_	25	conj	_	_
29	manner	manner	NN	NN	_	25	dep	_	_
30	;	;	:	:	_	21	punct	_	_
31	the	the	DT	DT	_	32	det	_	_
32	levels	level	NNS	NNS	_	40	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	39	compound	_	_
38	B-containing	b-containing	JJ	JJ	_	39	amod	_	_
39	plasmids	plasmid	NNS	NNS	_	35	nmod	_	_
40	correlated	correlate	VBD	VBD	_	21	parataxis	_	_
41	directly	directly	RB	RB	_	40	advmod	_	_
42	with	with	IN	IN	_	43	case	_	_
43	induction	induction	NN	NN	_	40	nmod	_	_
44	of	of	IN	IN	_	48	case	_	_
45	NF-kappa	nf-kappa	NN	NN	_	48	compound	_	_
46	B	b	NN	NN	_	48	compound	_	_
47	DNA-binding	dna-binding	JJ	JJ	_	48	amod	_	_
48	activity	activity	NN	NN	_	43	nmod	_	_
49	.	.	.	.	_	21	punct	_	_

1	Although	although	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	6	det	_	_
3	intact	intact	JJ	JJ	_	6	amod	_	_
4	beta	beta	NN	NN	_	6	compound	_	_
5	interferon	interferon	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
7	was	be	VBD	VBD	_	10	auxpass	_	_
8	only	only	RB	RB	_	9	advmod	_	_
9	weakly	weakly	RB	RB	_	10	advmod	_	_
10	stimulated	stimulate	VBN	VBN	_	25	advcl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	ester	ester	NN	NN	_	10	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	25	punct	_	_
17	multimers	multimer	NNS	NNS	_	25	nsubj	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	PRDII	prdii	NN	NN	_	23	compound	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B-binding	b-binding	JJ	JJ	_	23	amod	_	_
23	domain	domain	NN	NN	_	17	nmod	_	_
24	were	be	VBD	VBD	_	25	cop	_	_
25	inducible	inducible	JJ	JJ	_	0	root	_	_
26	by	by	IN	IN	_	28	case	_	_
27	both	both	DT	DT	_	28	det	_	_
28	agents	agent	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	25	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	able	able	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	increase	increase	VB	VB	_	3	xcomp	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	LTR	ltr	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	but	but	CC	CC	_	3	cc	_	_
16	in	in	IN	IN	_	18	case	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	23	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	TNF-alpha	tnf-alpha	NN	NN	_	23	nsubj	_	_
21	did	do	VBD	VBD	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	induce	induce	VB	VB	_	3	conj	_	_
24	the	the	DT	DT	_	26	det	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	LTR	ltr	NN	NN	_	23	dobj	_	_
27	above	above	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	constitutive	constitutive	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	23	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	activity	activity	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	level	level	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B-independent	b-independent	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	appears	appear	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	sufficient	sufficient	JJ	JJ	_	7	xcomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	multiplication	multiplication	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	since	since	IN	IN	_	18	mark	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	18	nsubj	_	_
18	had	have	VBD	VBD	_	7	advcl	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	kinetics	kinetics	NNS	NNS	_	18	nmod	_	_
24	of	of	IN	IN	_	33	case	_	_
25	de	de	FW	FW	_	33	amod	_	_
26	novo	novo	FW	FW	_	25	dep	_	_
27	HIV	hiv	NN	NN	_	28	compound	_	_
28	type	type	NN	NN	_	33	compound	_	_
29	1	1	CD	CD	_	28	nummod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	HIV-1	hiv-1	NN	NN	_	28	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	infection	infection	NN	NN	_	23	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	viral	viral	JJ	JJ	_	37	amod	_	_
36	RNA	rna	NN	NN	_	37	compound	_	_
37	production	production	NN	NN	_	33	conj	_	_
38	in	in	IN	IN	_	40	case	_	_
39	U937	u937	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	33	nmod	_	_
41	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	Jurkat	jurkat	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	9	nsubj	_	_
8	dramatically	dramatically	RB	RB	_	9	advmod	_	_
9	enhanced	enhance	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	spread	spread	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HIV-1	hiv-1	NN	NN	_	11	nmod	_	_
14	through	through	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	population	population	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	increased	increase	VBD	VBD	_	9	conj	_	_
20	viral	viral	JJ	JJ	_	22	amod	_	_
21	RNA	rna	NN	NN	_	22	compound	_	_
22	synthesis	synthesis	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	9	punct	_	_
24	indicating	indicate	VBG	VBG	_	9	advcl	_	_
25	that	that	IN	IN	_	32	mark	_	_
26	in	in	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	32	nmod	_	_
29	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
30	multiplication	multiplication	NN	NN	_	32	nsubjpass	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	stimulated	stimulate	VBN	VBN	_	24	ccomp	_	_
33	by	by	IN	IN	_	35	case	_	_
34	TNF-alpha	tnf-alpha	NN	NN	_	35	compound	_	_
35	treatment	treatment	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	internal	internal	JJ	JJ	_	4	amod	_	_
3	methionine	methionine	NN	NN	_	4	compound	_	_
4	codons	codon	NNS	NNS	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	13	case	_	_
6	human	human	JJ	JJ	_	13	amod	_	_
7	T-cell	t-cell	NN	NN	_	13	compound	_	_
8	leukemia	leukemia	NN	NN	_	13	compound	_	_
9	virus	virus	NN	NN	_	13	compound	_	_
10	type	type	NN	NN	_	13	compound	_	_
11	II	ii	CD	CD	_	13	nummod	_	_
12	rex	rex	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	4	nmod	_	_
14	are	be	VBP	VBP	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	required	require	VBN	VBN	_	0	root	_	_
17	for	for	IN	IN	_	19	case	_	_
18	p24rex	p24rex	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	16	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	virus	virus	NN	NN	_	19	conj	_	_
22	replication	replication	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	transformation	transformation	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	16	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	types	type	NNS	NNS	_	15	nsubj	_	_
6	I	i	CD	CD	_	5	dep	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-I	htlv-i	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	II	ii	CD	CD	_	5	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	HTLV-II	htlv-ii	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	have	have	VBP	VBP	_	0	root	_	_
16	two	two	CD	CD	_	20	nummod	_	_
17	nonstructural	nonstructural	JJ	JJ	_	20	amod	_	_
18	trans-acting	trans-acting	JJ	JJ	_	20	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	15	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	tax	tax	NN	NN	_	20	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	rex	rex	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	located	located	JJ	JJ	_	20	amod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	3'	3'	JJ	JJ	_	30	amod	_	_
30	region	region	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	viral	viral	JJ	JJ	_	34	amod	_	_
34	genome	genome	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	tax	tax	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	15	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	HTLV-I	htlv-i	NN	NN	_	7	compound	_	_
7	p40tax	p40tax	NN	NN	_	4	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	HTLV-II	htlv-ii	NN	NN	_	10	compound	_	_
10	p37tax	p37tax	NN	NN	_	7	conj	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activator	activator	NN	NN	_	0	root	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	viral	viral	JJ	JJ	_	21	amod	_	_
19	long	long	JJ	JJ	_	21	amod	_	_
20	terminal	terminal	JJ	JJ	_	21	amod	_	_
21	repeat	repeat	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	rex	rex	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	products	product	NNS	NNS	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	p27rex/p21rex	p27rex/p21rex	NN	NN	_	7	appos	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p26rex/p24rex	p26rex/p24rex	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	HTLV-I	htlv-i	NN	NN	_	4	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HTLV-II	htlv-ii	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	respectively	respectively	RB	RB	_	4	advmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Rex	rex	NN	NN	_	2	nsubj	_	_
2	acts	act	VBZ	VBZ	_	0	root	_	_
3	posttranscriptionally	posttranscriptionally	RB	RB	_	2	advmod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	facilitate	facilitate	VB	VB	_	2	xcomp	_	_
6	accumulation	accumulation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	full-length	full-length	JJ	JJ	_	9	amod	_	_
9	gag/pol	gag/pol	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	singly	singly	RB	RB	_	14	advmod	_	_
12	spliced	splice	VBN	VBN	_	14	amod	_	_
13	env	env	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	9	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cytoplasm	cytoplasm	NN	NN	_	6	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	HTLV-infected	htlv-infected	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	ATG	atg	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	rex	rex	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	critical	critical	JJ	JJ	_	3	ccomp	_	_
14	for	for	IN	IN	_	15	case	_	_
15	Rex	rex	NN	NN	_	13	nmod	_	_
16	production	production	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	function	function	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	internal	internal	JJ	JJ	_	6	amod	_	_
6	ATGs	atg	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	Rex	rex	NN	NN	_	9	compound	_	_
9	function	function	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	known	know	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	mutagenesis	mutagenesis	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	HTLV-I	htlv-i	NN	NN	_	10	compound	_	_
9	rex	rex	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	has	have	VBZ	VBZ	_	12	aux	_	_
12	provided	provide	VBN	VBN	_	0	root	_	_
13	indirect	indirect	JJ	JJ	_	14	amod	_	_
14	evidence	evidence	NN	NN	_	12	dobj	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	suggests	suggest	VBZ	VBZ	_	14	acl:relcl	_	_
17	that	that	IN	IN	_	26	mark	_	_
18	p21rex	p21rex	NN	NN	_	26	nsubj	_	_
19	,	,	,	,	_	18	punct	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	by	by	IN	IN	_	22	case	_	_
22	analogy	analogy	NN	NN	_	18	conj	_	_
23	HTLV-II	htlv-ii	NN	NN	_	24	compound	_	_
24	p24rex	p24rex	NN	NN	_	18	dep	_	_
25	,	,	,	,	_	18	punct	_	_
26	results	result	VBZ	VBZ	_	16	ccomp	_	_
27	from	from	IN	IN	_	28	case	_	_
28	initiation	initiation	NN	NN	_	26	nmod	_	_
29	at	at	IN	IN	_	32	case	_	_
30	an	a	DT	DT	_	32	det	_	_
31	internal	internal	JJ	JJ	_	32	amod	_	_
32	AUG	aug	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	tax/rex	tax/rex	NN	NN	_	36	compound	_	_
36	mRNA	mrna	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	11	advcl	_	_
3	an	a	DT	DT	_	6	det	_	_
4	infectious	infectious	JJ	JJ	_	6	amod	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	clone	clone	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	HTLV-II	htlv-ii	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	investigated	investigate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	importance	importance	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	internal	internal	JJ	JJ	_	17	amod	_	_
17	ATGs	atg	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	rex	rex	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	on	on	IN	IN	_	24	case	_	_
23	Rex	rex	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	13	nmod	_	_
25	production	production	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	function	function	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	p24rex	p24rex	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HTLV-II	htlv-ii	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	initiated	initiate	VBN	VBN	_	3	ccomp	_	_
11	at	at	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	internal	internal	JJ	JJ	_	14	amod	_	_
14	AUG	aug	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	20	det	_	_
18	internal	internal	JJ	JJ	_	20	amod	_	_
19	methionine	methionine	NN	NN	_	20	compound	_	_
20	codons	codon	NNS	NNS	_	23	nsubj	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	crucial	crucial	JJ	JJ	_	10	conj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	function	function	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	rex	rex	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	,	,	,	,	_	26	punct	_	_
33	ultimately	ultimately	RB	RB	_	26	advmod	_	_
34	,	,	,	,	_	26	punct	_	_
35	the	the	DT	DT	_	37	det	_	_
36	transforming	transforming	NN	NN	_	37	compound	_	_
37	properties	property	NNS	NNS	_	26	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	virus	virus	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	Interferon	interferon	NN	NN	_	2	nsubj	_	_
2	affects	affect	VBZ	VBZ	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	4	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	clinically	clinically	RB	RB	_	9	advmod	_	_
9	sensitive	sensitive	JJ	JJ	_	13	amod	_	_
10	chronic	chronic	JJ	JJ	_	13	amod	_	_
11	myelogenous	myelogenous	JJ	JJ	_	13	amod	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	6	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Cytoplasmic	cytoplasmic	JJ	JJ	_	3	amod	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	extracts	extract	NNS	NNS	_	12	nsubj	_	_
4	from	from	IN	IN	_	11	case	_	_
5	chronic	chronic	JJ	JJ	_	11	amod	_	_
6	myelogenous	myelogenous	JJ	JJ	_	11	amod	_	_
7	leukemia	leukemia	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	CML	cml	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	contained	contain	VBD	VBD	_	0	root	_	_
13	an	a	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	altered	alter	VBD	VBD	_	14	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	electrophoretic	electrophoretic	JJ	JJ	_	19	amod	_	_
19	mobility	mobility	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	complexes	complex	NNS	NNS	_	19	nmod	_	_
22	formed	form	VBN	VBN	_	21	acl	_	_
23	between	between	IN	IN	_	25	case	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	enhancers	enhancer	NNS	NNS	_	25	conj	_	_
30	of	of	IN	IN	_	36	case	_	_
31	interferon	interferon	NN	NN	_	36	compound	_	_
32	(	(	-LRB-	-LRB-	_	36	punct	_	_
33	IFN	ifn	NN	NN	_	36	compound	_	_
34	)	)	-RRB-	-RRB-	_	36	punct	_	_
35	-inducible	-inducible	JJ	JJ	_	36	amod	_	_
36	genes	gene	NNS	NNS	_	29	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	Exposure	exposure	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CML	cml	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	1	dep	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	5	dobj	_	_
7	diminished	diminish	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	CML	cml	NN	NN	_	14	compound	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	9	nmod	_	_
15	on	on	IN	IN	_	19	case	_	_
16	these	these	DT	DT	_	19	det	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	protein-DNA	protein-dna	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	clinical	clinical	JJ	JJ	_	5	amod	_	_
5	responsiveness	responsiveness	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	5	dep	_	_
7	IFN-alpha	ifn-alpha	NN	NN	_	6	dobj	_	_
8	correlated	correlate	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	sensitivity	sensitivity	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IFN-induced	ifn-induced	JJ	JJ	_	15	amod	_	_
15	change	change	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	electrophoretic	electrophoretic	JJ	JJ	_	19	amod	_	_
19	mobility	mobility	NN	NN	_	11	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
22	protein-DNA	protein-dna	JJ	JJ	_	23	amod	_	_
23	complexes	complex	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	action	action	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IFN-alpha	ifn-alpha	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	CML	cml	NN	NN	_	6	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	linked	link	VBN	VBN	_	3	ccomp	_	_
14	to	to	TO	TO	_	13	dep	_	_
15	a	a	DT	DT	_	16	det	_	_
16	pathway	pathway	NN	NN	_	14	dobj	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	result	result	VB	VB	_	16	acl:relcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	posttranslational	posttranslational	JJ	JJ	_	22	amod	_	_
22	modification	modification	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Retroviral	retroviral	JJ	JJ	_	2	dep	_	_
2	mediated	mediate	VBN	VBN	_	3	amod	_	_
3	transfer	transfer	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	expression	expression	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	exogenous	exogenous	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	3	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	assaying	assay	VBG	VBG	_	3	dep	_	_
15	for	for	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	viral	viral	JJ	JJ	_	19	amod	_	_
18	transactivator	transactivator	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	normal	normal	JJ	JJ	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	malignant	malignant	JJ	JJ	_	21	conj	_	_
24	cells	cell	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	describe	describe	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	recombinant	recombinant	JJ	JJ	_	10	amod	_	_
10	retroviruses	retrovirus	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	characterize	characterize	VB	VB	_	5	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	exogenous	exogenous	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	primary	primary	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	24	case	_	_
24	patients	patient	NNS	NNS	_	22	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	lymphoproliferative	lymphoproliferative	JJ	JJ	_	27	amod	_	_
27	disorders	disorder	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	infection	infection	NN	NN	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	variety	variety	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cultured	culture	VBN	VBN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	conj	_	_
12	with	with	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	recombinant	recombinant	JJ	JJ	_	15	amod	_	_
15	retrovirus	retrovirus	NN	NN	_	7	nmod	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	a	a	DT	DT	_	21	det	_	_
18	histone	histone	NN	NN	_	21	compound	_	_
19	promoter-driven	promoter-driven	JJ	JJ	_	21	amod	_	_
20	beta-galactosidase	beta-galactosidase	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	16	dobj	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	shown	show	VBN	VBN	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	result	result	VB	VB	_	23	xcomp	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	beta-galactosidase	beta-galactosidase	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	36	case	_	_
32	50	50	CD	CD	_	36	compound	_	_
33	%	%	NN	NN	_	36	dep	_	_
34	to	to	TO	TO	_	36	dep	_	_
35	100	100	CD	CD	_	36	compound	_	_
36	%	%	NN	NN	_	30	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	23	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	infection	infection	NN	NN	_	18	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
7	retrovirus	retrovirus	NN	NN	_	3	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	beta-galactosidase	beta-galactosidase	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	8	dobj	_	_
12	with	with	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	adenovirus	adenovirus	NN	NN	_	16	compound	_	_
15	E2	e2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	results	result	VBZ	VBZ	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	beta-galactosidase	beta-galactosidase	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	limited	limited	JJ	JJ	_	25	amod	_	_
25	number	number	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	cultured	culture	VBN	VBN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	primary	primary	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	conj	_	_
31	.	.	.	.	_	18	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	adenovirus	adenovirus	NN	NN	_	5	compound	_	_
4	E2	e2	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	9	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	9	aux	_	_
7	been	be	VBN	VBN	_	9	auxpass	_	_
8	well	well	RB	RB	_	9	advmod	_	_
9	characterized	characterize	VBN	VBN	_	33	advcl	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	known	know	VBN	VBN	_	9	conj	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	regulated	regulate	VBN	VBN	_	12	xcomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	transactivators	transactivator	NNS	NNS	_	15	nmod	_	_
18	encoded	encode	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	many	many	JJ	JJ	_	21	amod	_	_
21	viruses	virus	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	33	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activity	activity	NN	NN	_	33	nsubjpass	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	promoter	promoter	NN	NN	_	24	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	specific	specific	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	types	type	NNS	NNS	_	24	nmod	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	discussed	discuss	VBN	VBN	_	0	root	_	_
34	in	in	IN	IN	_	35	case	_	_
35	reference	reference	NN	NN	_	33	nmod	_	_
36	to	to	TO	TO	_	35	dep	_	_
37	both	both	CC	CC	_	39	cc:preconj	_	_
38	the	the	DT	DT	_	39	det	_	_
39	biology	biology	NN	NN	_	36	dobj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	cell	cell	NN	NN	_	39	nmod	_	_
43	and	and	CC	CC	_	39	cc	_	_
44	the	the	DT	DT	_	46	det	_	_
45	possible	possible	JJ	JJ	_	46	amod	_	_
46	presence	presence	NN	NN	_	39	conj	_	_
47	of	of	IN	IN	_	53	case	_	_
48	as	as	RB	RB	_	49	advmod	_	_
49	yet	yet	RB	RB	_	50	advmod	_	_
50	undetected	undetected	JJ	JJ	_	53	amod	_	_
51	viral	viral	JJ	JJ	_	53	amod	_	_
52	gene	gene	NN	NN	_	53	compound	_	_
53	products	product	NNS	NNS	_	46	nmod	_	_
54	.	.	.	.	_	33	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	on	on	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
7	mononuclear	mononuclear	JJ	JJ	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	polymorphonuclear	polymorphonuclear	JJ	JJ	_	7	conj	_	_
10	leucocytes	leucocyte	NNS	NNS	_	7	dep	_	_
11	:	:	:	:	_	3	punct	_	_
12	changes	change	NNS	NNS	_	3	dep	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	yang-deficiency	yang-deficiency	NN	NN	_	14	nmod	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	,	,	,	,	_	25	punct	_	_
6	in	in	IN	IN	_	8	case	_	_
7	former	former	JJ	JJ	_	8	amod	_	_
8	works	work	NNS	NNS	_	25	nmod	_	_
9	,	,	,	,	_	25	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	25	nsubjpass	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	GCR	gcr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	on	on	IN	IN	_	19	case	_	_
17	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
18	mixed	mixed	JJ	JJ	_	19	amod	_	_
19	leucocytes	leucocyte	NNS	NNS	_	12	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	patients	patient	NNS	NNS	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	Yang-deficiency	yang-deficiency	NN	NN	_	21	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	decreased	decrease	VBN	VBN	_	3	ccomp	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	work	work	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	mixed	mixed	JJ	JJ	_	7	amod	_	_
7	leucocytes	leucocyte	NNS	NNS	_	10	nsubjpass	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	separated	separate	VBN	VBN	_	0	root	_	_
11	into	into	IN	IN	_	12	case	_	_
12	mononuclear	mononuclear	JJ	JJ	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	MNL	mnl	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	polymorphonuclear	polymorphonuclear	NN	NN	_	12	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PML	pml	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	leucocytes	leucocyte	NNS	NNS	_	12	dep	_	_
22	,	,	,	,	_	10	punct	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	GCR	gcr	NN	NN	_	26	nsubjpass	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	determined	determine	VBN	VBN	_	10	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	each	each	DT	DT	_	29	det	_	_
29	part	part	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	leucocytes	leucocyte	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	GCR	gcr	NN	NN	_	12	nsubj	_	_
2	on	on	IN	IN	_	3	case	_	_
3	MNL	mnl	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	PML	pml	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	6	6	CD	CD	_	10	nummod	_	_
8	Yang	yang	NN	NN	_	10	compound	_	_
9	deficient	deficient	JJ	JJ	_	10	amod	_	_
10	patients	patient	NNS	NNS	_	3	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	3473	3473	CD	CD	_	0	root	_	_
13	+/-	+/-	CC	CC	_	12	cc	_	_
14	413	413	CD	CD	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	4433	4433	CD	CD	_	12	conj	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	651	651	CD	CD	_	16	conj	_	_
19	sites/cell	sites/cell	NNS	NNS	_	12	dep	_	_
20	respectively	respectively	RB	RB	_	12	advmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	statistically	statistically	RB	RB	_	23	advmod	_	_
23	significant	significant	JJ	JJ	_	12	advmod	_	_
24	from	from	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	normal	normal	JJ	JJ	_	28	amod	_	_
27	control	control	JJ	JJ	_	28	amod	_	_
28	group	group	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	4462	4462	CD	CD	_	23	dep	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	962	962	CD	CD	_	30	conj	_	_
33	and	and	CC	CC	_	30	cc	_	_
34	5622	5622	CD	CD	_	30	conj	_	_
35	+/-	+/-	CC	CC	_	34	cc	_	_
36	782	782	CD	CD	_	34	conj	_	_
37	sites/cell	sites/cell	NNS	NNS	_	30	dep	_	_
38	respectively	respectively	RB	RB	_	30	advmod	_	_
39	,	,	,	,	_	30	punct	_	_
40	P	p	NN	NN	_	30	appos	_	_
41	less	less	JJR	JJR	_	40	amod	_	_
42	than	than	IN	IN	_	43	case	_	_
43	0.05	0.05	CD	CD	_	41	nmod	_	_
44	)	)	-RRB-	-RRB-	_	30	punct	_	_
45	.	.	.	.	_	12	punct	_	_

1	GCR	gcr	NN	NN	_	13	nsubjpass	_	_
2	on	on	IN	IN	_	3	case	_	_
3	MNL	mnl	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	PML	pml	NN	NN	_	3	conj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	mixed	mixed	JJ	JJ	_	8	amod	_	_
8	leucocytes	leucocyte	NNS	NNS	_	3	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	5	5	CD	CD	_	11	nummod	_	_
11	patients	patient	NNS	NNS	_	3	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	determined	determine	VBN	VBN	_	0	root	_	_
14	simultaneously	simultaneously	RB	RB	_	13	advmod	_	_
15	,	,	,	,	_	13	punct	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	all	all	DT	DT	_	18	nsubj	_	_
18	lowered	lower	VBD	VBD	_	13	conj	_	_
19	from	from	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	control	control	JJ	JJ	_	22	amod	_	_
22	group	group	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	3369	3369	CD	CD	_	0	root	_	_
5	+/-	+/-	CC	CC	_	4	cc	_	_
6	370	370	CD	CD	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	4986	4986	CD	CD	_	4	conj	_	_
9	+/-	+/-	CC	CC	_	8	cc	_	_
10	419	419	CD	CD	_	8	conj	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	4524	4524	CD	CD	_	4	conj	_	_
13	+/-	+/-	CC	CC	_	12	cc	_	_
14	852	852	CD	CD	_	12	conj	_	_
15	sites/cell	sites/cell	NNS	NNS	_	4	dep	_	_
16	respectively	respectively	RB	RB	_	4	advmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	lowest	lowest	JJS	JJS	_	21	amod	_	_
21	GCR	gcr	NN	NN	_	4	nmod	_	_
22	on	on	IN	IN	_	23	case	_	_
23	MNL	mnl	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	highest	highest	JJS	JJS	_	21	conj	_	_
26	on	on	IN	IN	_	27	case	_	_
27	PML	pml	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	0	root	_	_
5	on	on	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	13	mark	_	_
5	have	have	VB	VB	_	13	aux	_	_
6	a	a	DT	DT	_	8	det	_	_
7	lytic	lytic	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	13	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	leukemic	leukemic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	13	nmod	_	_
12	via	via	IN	IN	_	13	dep	_	_
13	interactions	interaction	NNS	NNS	_	3	xcomp	_	_
14	with	with	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	GR	gr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	Cortisol	cortisol	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	various	various	JJ	JJ	_	5	amod	_	_
4	synthetic	synthetic	JJ	JJ	_	5	amod	_	_
5	glucocorticoids	glucocorticoid	NNS	NNS	_	1	conj	_	_
6	bind	bind	VBP	VBP	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	GR	gr	NN	NN	_	6	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	one-site	one-site	JJ	JJ	_	12	amod	_	_
12	kinetics	kinetics	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Cortivazol	cortivazol	NN	NN	_	12	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CVZ	cvz	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	12	cop	_	_
6	a	a	DT	DT	_	12	det	_	_
7	unique	unique	JJ	JJ	_	12	amod	_	_
8	,	,	,	,	_	12	punct	_	_
9	high	high	JJ	JJ	_	12	amod	_	_
10	potency	potency	NN	NN	_	12	compound	_	_
11	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	has	have	VBZ	VBZ	_	12	acl:relcl	_	_
16	a	a	DT	DT	_	17	det	_	_
17	phenylpyrazol	phenylpyrazol	JJ	JJ	_	15	dobj	_	_
18	fused	fuse	VBN	VBN	_	17	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	A-ring	a-ring	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	steroid	steroid	NN	NN	_	25	compound	_	_
25	nucleus	nucleus	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	displays	display	VBZ	VBZ	_	15	conj	_	_
28	binding	binding	NN	NN	_	27	dobj	_	_
29	consistent	consistent	JJ	JJ	_	28	amod	_	_
30	with	with	IN	IN	_	31	case	_	_
31	two	two	CD	CD	_	29	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	more	more	JJR	JJR	_	31	conj	_	_
34	sites	site	NNS	NNS	_	31	dep	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	cytosol	cytosol	NN	NN	_	31	nmod	_	_
38	from	from	IN	IN	_	41	case	_	_
39	CEM	cem	NN	NN	_	41	compound	_	_
40	C7	c7	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	37	nmod	_	_
42	(	(	-LRB-	-LRB-	_	48	punct	_	_
43	a	a	DT	DT	_	48	det	_	_
44	human	human	JJ	JJ	_	48	amod	_	_
45	acute	acute	JJ	JJ	_	48	amod	_	_
46	lymphoblastic	lymphoblastic	JJ	JJ	_	48	amod	_	_
47	T-cell	t-cell	NN	NN	_	48	compound	_	_
48	line	line	NN	NN	_	41	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	.	.	.	.	_	12	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	previously	previously	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	lower	lower	JJR	JJR	_	10	amod	_	_
9	affinity	affinity	NN	NN	_	10	compound	_	_
10	class	class	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	sites	site	NNS	NNS	_	10	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	similar	similar	JJ	JJ	_	5	ccomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	affinity	affinity	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	site	site	NN	NN	_	19	compound	_	_
19	molarity	molarity	NN	NN	_	16	conj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	those	those	DT	DT	_	14	nmod	_	_
22	recognized	recognize	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	dexamethasone	dexamethasone	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	higher	higher	JJR	JJR	_	4	amod	_	_
3	affinity	affinity	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	5	nsubj	_	_
5	bind	bind	VBP	VBP	_	0	root	_	_
6	CVZ	cvz	NN	NN	_	5	dobj	_	_
7	with	with	IN	IN	_	12	case	_	_
8	20-	20-	CD	CD	_	11	nmod:npmod	_	_
9	to	to	TO	TO	_	8	dep	_	_
10	50-fold	50-fold	RB	RB	_	8	advmod	_	_
11	greater	greater	JJR	JJR	_	12	amod	_	_
12	affinity	affinity	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	consistent	consistent	JJ	JJ	_	5	advmod	_	_
15	with	with	IN	IN	_	20	case	_	_
16	CVZ	cvz	NN	NN	_	20	nmod:poss	_	_
17	's	's	POS	POS	_	20	case	_	_
18	enhanced	enhance	VBN	VBN	_	20	amod	_	_
19	biological	biological	JJ	JJ	_	20	amod	_	_
20	effects	effect	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	mutant	mutant	JJ	JJ	_	4	amod	_	_
3	leukemic	leukemic	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	15	nmod	_	_
5	resistant	resistant	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	lytic	lytic	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	dexamethasone	dexamethasone	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	CVZ	cvz	NN	NN	_	15	nsubj	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	lyses	lys	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	15	dobj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	recognizes	recognize	VBZ	VBZ	_	15	conj	_	_
20	a	a	DT	DT	_	22	det	_	_
21	single	single	JJ	JJ	_	22	amod	_	_
22	class	class	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	sites	site	NNS	NNS	_	22	nmod	_	_
25	similar	similar	JJ	JJ	_	22	amod	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	high	high	JJ	JJ	_	30	amod	_	_
29	affinity	affinity	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	CEM	cem	NN	NN	_	34	compound	_	_
33	C7	c7	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	carried	carry	VBN	VBN	_	0	root	_	_
4	out	out	RP	RP	_	3	compound:prt	_	_
5	experiments	experiment	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	define	define	VB	VB	_	3	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nature	nature	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	higher	higher	JJR	JJR	_	16	amod	_	_
13	affinity	affinity	NN	NN	_	16	compound	_	_
14	CVZ	cvz	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	:	:	:	:	_	9	punct	_	_
6	1	1	LS	LS	_	9	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	CVZ	cvz	NN	NN	_	9	nsubj	_	_
9	has	have	VBZ	VBZ	_	3	ccomp	_	_
10	more	more	JJR	JJR	_	12	advmod	_	_
11	than	than	IN	IN	_	10	mwe	_	_
12	one	one	CD	CD	_	14	nummod	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	site	site	NN	NN	_	9	dobj	_	_
15	in	in	IN	IN	_	22	case	_	_
16	a	a	DT	DT	_	22	det	_	_
17	second	second	JJ	JJ	_	22	amod	_	_
18	,	,	,	,	_	17	punct	_	_
19	independent	independent	JJ	JJ	_	17	dep	_	_
20	,	,	,	,	_	22	punct	_	_
21	B-cell	b-cell	NN	NN	_	22	dep	_	_
22	line	line	NN	NN	_	9	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	IM-9	im-9	NN	NN	_	22	appos	_	_
25	;	;	:	:	_	9	punct	_	_
26	2	2	LS	LS	_	33	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	the	the	DT	DT	_	30	det	_	_
29	antiglucocorticoid	antiglucocorticoid	JJ	JJ	_	30	amod	_	_
30	RU	ru	NN	NN	_	33	nsubj	_	_
31	38486	38486	CD	CD	_	30	nummod	_	_
32	is	be	VBZ	VBZ	_	33	cop	_	_
33	able	able	JJ	JJ	_	9	conj	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	block	block	VB	VB	_	33	xcomp	_	_
36	both	both	CC	CC	_	37	cc:preconj	_	_
37	CVZ	cvz	NN	NN	_	35	dobj	_	_
38	's	's	POS	POS	_	37	case	_	_
39	higher	higher	JJR	JJR	_	37	dep	_	_
40	and	and	CC	CC	_	37	cc	_	_
41	lower	lower	JJR	JJR	_	37	conj	_	_
42	affinity	affinity	NN	NN	_	43	compound	_	_
43	sites	site	NNS	NNS	_	37	dep	_	_
44	;	;	:	:	_	9	punct	_	_
45	3	3	LS	LS	_	56	dep	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	all	all	DT	DT	_	56	nsubj	_	_
48	of	of	IN	IN	_	52	case	_	_
49	CVZ	cvz	NN	NN	_	52	nmod:poss	_	_
50	's	's	POS	POS	_	52	case	_	_
51	binding	bind	VBG	VBG	_	52	amod	_	_
52	sites	site	NNS	NNS	_	47	nmod	_	_
53	are	be	VBP	VBP	_	56	cop	_	_
54	on	on	IN	IN	_	56	case	_	_
55	a	a	DT	DT	_	56	det	_	_
56	protein	protein	NN	NN	_	9	conj	_	_
57	immunologically	immunologically	RB	RB	_	58	advmod	_	_
58	indistinguishable	indistinguishable	JJ	JJ	_	56	amod	_	_
59	from	from	IN	IN	_	62	case	_	_
60	the	the	DT	DT	_	62	det	_	_
61	human	human	JJ	JJ	_	62	amod	_	_
62	GR	gr	NN	NN	_	58	nmod	_	_
63	;	;	:	:	_	9	punct	_	_
64	and	and	CC	CC	_	9	cc	_	_
65	4	4	LS	LS	_	74	dep	_	_
66	)	)	-RRB-	-RRB-	_	65	punct	_	_
67	freshly	freshly	RB	RB	_	69	advmod	_	_
68	isolated	isolate	VBN	VBN	_	69	amod	_	_
69	clones	clone	NNS	NNS	_	74	nsubj	_	_
70	of	of	IN	IN	_	72	case	_	_
71	CVZ-resistant	cvz-resistant	JJ	JJ	_	72	amod	_	_
72	cells	cell	NNS	NNS	_	69	nmod	_	_
73	have	have	VBP	VBP	_	74	aux	_	_
74	lost	lose	VBN	VBN	_	9	conj	_	_
75	all	all	DT	DT	_	77	det	_	_
76	binding	bind	VBG	VBG	_	77	amod	_	_
77	sites	site	NNS	NNS	_	74	dobj	_	_
78	for	for	IN	IN	_	79	case	_	_
79	CVZ	cvz	NN	NN	_	77	nmod	_	_
80	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CVZ	cvz	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	aux	_	_
7	recognizing	recognize	VBG	VBG	_	3	ccomp	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	7	dobj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	GR	gr	NN	NN	_	11	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	a	a	DT	DT	_	18	det	_	_
18	protein	protein	NN	NN	_	15	conj	_	_
19	very	very	RB	RB	_	20	advmod	_	_
20	similar	similar	JJ	JJ	_	18	amod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	it	it	PRP	PRP	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	The	the	DT	DT	_	3	det	_	_
3	role	role	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	HLA	hla	NN	NN	_	9	compound	_	_
9	antigens	antigen	NNS	NNS	_	6	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	pathogenesis	pathogenesis	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	Cushing	cushing	NN	NN	_	16	nmod:poss	_	_
15	's	's	POS	POS	_	16	case	_	_
16	syndrome	syndrome	NN	NN	_	12	nmod	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Lymphocytic	lymphocytic	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	evaluated	evaluate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	114	114	CD	CD	_	10	nummod	_	_
10	patients	patient	NNS	NNS	_	7	nmod	_	_
11	suffering	suffer	VBG	VBG	_	10	acl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	Icenko-Cushing	icenko-cushing	NN	NN	_	15	nmod:poss	_	_
14	's	's	POS	POS	_	15	case	_	_
15	syndrome	syndrome	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Incidence	incidence	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HLA	hla	NN	NN	_	4	compound	_	_
4	antigens	antigen	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	determined	determine	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	94	94	CD	CD	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	them	they	PRP	PRP	_	8	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	rise	rise	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	A10	a10	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	B27	b27	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	incidence	incidence	NN	NN	_	5	conj	_	_
10	compared	compare	VBN	VBN	_	12	case	_	_
11	to	to	TO	TO	_	12	case	_	_
12	that	that	DT	DT	_	3	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	normal	normal	JJ	JJ	_	15	amod	_	_
15	subjects	subject	NNS	NNS	_	12	nmod	_	_
16	allows	allow	VBZ	VBZ	_	0	root	_	_
17	these	these	DT	DT	_	18	det	_	_
18	antigens	antigen	NNS	NNS	_	16	dobj	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	considered	consider	VBN	VBN	_	16	xcomp	_	_
22	genetic	genetic	JJ	JJ	_	23	amod	_	_
23	markers	marker	NNS	NNS	_	21	xcomp	_	_
24	of	of	IN	IN	_	27	case	_	_
25	Icenko-Cushing	icenko-cushing	NN	NN	_	27	nmod:poss	_	_
26	's	's	POS	POS	_	27	case	_	_
27	syndrome	syndrome	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	patients	patient	NNS	NNS	_	7	nmod	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	lower	lower	JJR	JJR	_	0	root	_	_
13	than	than	IN	IN	_	16	case	_	_
14	in	in	IN	IN	_	16	case	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	12	nmod	_	_
17	both	both	CC	CC	_	12	dep	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	active	active	JJ	JJ	_	21	amod	_	_
21	stage	stage	NN	NN	_	12	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	disease	disease	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	following	follow	VBG	VBG	_	29	amod	_	_
27	bilateral	bilateral	JJ	JJ	_	29	amod	_	_
28	total	total	JJ	JJ	_	27	dep	_	_
29	adrenalectomy	adrenalectomy	NN	NN	_	21	conj	_	_
30	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	6	nsubj	_	_
3	carrying	carry	VBG	VBG	_	2	acl	_	_
4	B27	b27	NN	NN	_	5	compound	_	_
5	antigen	antigen	NN	NN	_	3	dobj	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	lymphocytic	lymphocytic	JJ	JJ	_	9	amod	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	concentrations	concentration	NNS	NNS	_	6	dobj	_	_
10	under	under	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	levels	level	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	such	such	JJ	JJ	_	12	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	free	free	JJ	JJ	_	16	amod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	antigen	antigen	JJ	JJ	_	21	amod	_	_
21	carriage	carriage	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Antigen	antigen	NN	NN	_	2	compound	_	_
2	B27	b27	NN	NN	_	3	nsubj	_	_
3	seems	seem	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	mark	_	_
5	be	be	VB	VB	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cause	cause	NN	NN	_	3	xcomp	_	_
8	of	of	IN	IN	_	10	case	_	_
9	lower	lower	JJR	JJR	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Astrocytes	astrocyte	NNS	NNS	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	glioblastoma	glioblastoma	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	conj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	novel	novel	JJ	JJ	_	9	amod	_	_
7	octamer-DNA	octamer-dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	5	dobj	_	_
10	distinct	distinct	JJ	JJ	_	9	amod	_	_
11	from	from	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	ubiquitous	ubiquitous	JJ	JJ	_	14	amod	_	_
14	Oct-1	oct-1	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	B	b	NN	NN	_	20	compound	_	_
17	cell	cell	NN	NN	_	20	compound	_	_
18	type	type	NN	NN	_	20	compound	_	_
19	Oct-2	oct-2	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	14	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	'	'	``	``	_	5	punct	_	_
3	octamer	octamer	NN	NN	_	5	compound	_	_
4	'	'	''	''	_	5	punct	_	_
5	sequence	sequence	NN	NN	_	16	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	ATGCAAAT	atgcaaat	NN	NN	_	5	appos	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	complement	complement	NN	NN	_	11	compound	_	_
11	ATTTGCAT	atttgcat	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	key	key	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	0	root	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	immunoglobulin	immunoglobulin	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	B-lymphocytes	b-lymphocyte	NNS	NNS	_	23	nmod	_	_
26	as	as	RB	RB	_	23	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	a	a	DT	DT	_	30	det	_	_
30	number	number	NN	NN	_	23	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	housekeeping	housekeeping	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	30	nmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	all	all	DT	DT	_	37	det	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	types	type	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	octamer-binding	octamer-binding	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	12	nsubjpass	_	_
7	Oct-2A	oct-2a	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	variants	variant	NNS	NNS	_	6	conj	_	_
10	thereof	thereof	RB	RB	_	9	advmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	thought	think	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	contribute	contribute	VB	VB	_	12	xcomp	_	_
15	to	to	TO	TO	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	B-cell	b-cell	NN	NN	_	20	compound	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	while	while	IN	IN	_	27	mark	_	_
23	the	the	DT	DT	_	26	det	_	_
24	ubiquitous	ubiquitous	JJ	JJ	_	26	amod	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	Oct-1	oct-1	NN	NN	_	27	nsubj	_	_
27	seems	seem	VBZ	VBZ	_	12	advcl	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	control	control	VB	VB	_	27	xcomp	_	_
30	general	general	JJ	JJ	_	33	amod	_	_
31	octamer	octamer	NN	NN	_	33	compound	_	_
32	site-dependent	site-dependent	JJ	JJ	_	33	amod	_	_
33	transcription	transcription	NN	NN	_	29	dobj	_	_
34	.	.	.	.	_	12	punct	_	_

1	Various	various	JJ	JJ	_	3	amod	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	genes	gene	NNS	NNS	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	for	for	IN	IN	_	6	case	_	_
6	example	example	NN	NN	_	3	nmod	_	_
7	interleukin-1	interleukin-1	NN	NN	_	3	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	MHC	mhc	NN	NN	_	10	compound	_	_
10	class	class	NN	NN	_	7	conj	_	_
11	II	ii	CD	CD	_	10	nummod	_	_
12	genes	gene	NNS	NNS	_	7	dep	_	_
13	,	,	,	,	_	3	punct	_	_
14	contain	contain	VBP	VBP	_	0	root	_	_
15	an	a	DT	DT	_	17	det	_	_
16	octamer	octamer	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	promoter	promoter	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	expressed	express	VBN	VBN	_	14	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	cells	cell	NNS	NNS	_	23	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	both	both	CC	CC	_	29	cc:preconj	_	_
28	the	the	DT	DT	_	29	dep	_	_
29	immune	immune	JJ	JJ	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	nervous	nervous	JJ	JJ	_	29	conj	_	_
32	systems	system	NNS	NNS	_	29	dep	_	_
33	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	prompted	prompt	VBD	VBD	_	0	root	_	_
3	us	we	PRP	PRP	_	2	dobj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	analyze	analyze	VB	VB	_	2	xcomp	_	_
6	the	the	DT	DT	_	8	det	_	_
7	octamer-binding	octamer-binding	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	latter	latter	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	6	det	_	_
3	electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	1	dobj	_	_
7	,	,	,	,	_	1	punct	_	_
8	at	at	IN	IN	_	9	case	_	_
9	least	least	JJS	JJS	_	10	nmod:npmod	_	_
10	six	six	CD	CD	_	14	nummod	_	_
11	novel	novel	JJ	JJ	_	14	amod	_	_
12	octamer	octamer	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	detected	detect	VBN	VBN	_	1	parataxis	_	_
17	in	in	IN	IN	_	19	case	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	extracts	extract	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	cultured	culture	VBN	VBN	_	23	amod	_	_
22	mouse	mouse	NN	NN	_	23	compound	_	_
23	astrocytes	astrocyte	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
3	are	be	VBP	VBP	_	5	auxpass	_	_
4	differentially	differentially	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	glioblastoma	glioblastoma	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	neuroblastoma	neuroblastoma	NN	NN	_	8	conj	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	8	dep	_	_
13	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	nervous	nervous	JJ	JJ	_	7	amod	_	_
3	system-derived	system-derived	JJ	JJ	_	7	amod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	N-Oct	n-oct	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	proteins	protein	NNS	NNS	_	8	nsubj	_	_
8	bound	bind	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	octamer	octamer	NN	NN	_	13	compound	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	manner	manner	NN	NN	_	8	nmod	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	indistinguishable	indistinguishable	JJ	JJ	_	16	acl:relcl	_	_
20	from	from	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	Oct-1	oct-1	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Oct-2A	oct-2a	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	22	conj	_	_
26	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	relationship	relationship	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	N-Oct	n-oct	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	Oct-1	oct-1	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Oct-2A	oct-2a	NN	NN	_	8	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	analyzed	analyze	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	proteolytic	proteolytic	JJ	JJ	_	17	amod	_	_
15	clipping	clipping	JJ	JJ	_	17	amod	_	_
16	bandshift	bandshift	NN	NN	_	17	compound	_	_
17	assays	assay	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	by	by	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	reactivity	reactivity	NN	NN	_	17	conj	_	_
22	towards	towards	IN	IN	_	23	case	_	_
23	antisera	antisera	NNS	NNS	_	21	nmod	_	_
24	raised	raise	VBN	VBN	_	23	acl	_	_
25	against	against	IN	IN	_	27	case	_	_
26	recombinant	recombinant	JJ	JJ	_	27	amod	_	_
27	Oct-1	oct-1	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	Oct-2A	oct-2a	NN	NN	_	27	conj	_	_
30	proteins	protein	NNS	NNS	_	27	dep	_	_
31	.	.	.	.	_	12	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	assays	assay	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	all	all	DT	DT	_	9	det	_	_
9	N-Oct-factors	n-oct-factor	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	distinct	distinct	JJ	JJ	_	11	xcomp	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	ubiquitous	ubiquitous	JJ	JJ	_	18	amod	_	_
18	Oct-1	oct-1	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	lymphoid-specific	lymphoid-specific	JJ	JJ	_	22	amod	_	_
22	Oct-2A	oct-2a	NN	NN	_	18	conj	_	_
23	proteins	protein	NNS	NNS	_	18	dep	_	_
24	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	melanoma	melanoma	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	14	nmod	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	contain	contain	VBP	VBP	_	3	acl:relcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	N-Oct-3	n-oct-3	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	14	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	transfected	transfect	VBN	VBN	_	13	amod	_	_
12	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	13	amod	_	_
13	promoter	promoter	NN	NN	_	14	nsubjpass	_	_
14	was	be	VBD	VBD	_	0	root	_	_
15	neither	neither	CC	CC	_	14	dep	_	_
16	activated	activate	VBN	VBN	_	14	conj	_	_
17	nor	nor	CC	CC	_	14	cc	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	it	it	PRP	PRP	_	20	nsubjpass	_	_
20	repressed	repress	VBN	VBN	_	14	conj	_	_
21	upon	upon	IN	IN	_	22	case	_	_
22	contransfection	contransfection	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	27	case	_	_
24	an	a	DT	DT	_	27	det	_	_
25	Oct-2A	oct-2a	NN	NN	_	27	compound	_	_
26	expression	expression	NN	NN	_	27	compound	_	_
27	vector	vector	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	speculate	speculate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	N-Oct-3	n-oct-3	NN	NN	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	other	other	JJ	JJ	_	9	amod	_	_
8	N-Oct	n-oct	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	conj	_	_
10	have	have	VBP	VBP	_	3	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nervous	nervous	JJ	JJ	_	22	amod	_	_
22	system	system	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Circadian	circadian	JJ	JJ	_	2	amod	_	_
2	rhythm	rhythm	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
9	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	reactivity	reactivity	NN	NN	_	2	conj	_	_
13	to	to	TO	TO	_	12	dep	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	13	dobj	_	_
15	.	.	.	.	_	2	punct	_	_

1	1	1	LS	LS	_	4	dep	_	_
2	)	)	-RRB-	-RRB-	_	1	punct	_	_
3	There	there	EX	EX	_	4	expl	_	_
4	exists	exist	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	CR	cr	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GR	gr	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	PMN	pmn	NN	NN	_	6	appos	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	monocytes	monocyte	NNS	NNS	_	6	conj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	peak	peak	NN	NN	_	20	compound	_	_
20	values	value	NNS	NNS	_	16	nmod	_	_
21	from	from	IN	IN	_	25	case	_	_
22	0400	0400	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	0800	0800	CD	CD	_	25	nummod	_	_
25	hr	hr	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	trough	trough	NN	NN	_	29	compound	_	_
29	values	value	NNS	NNS	_	20	conj	_	_
30	between	between	IN	IN	_	34	case	_	_
31	2300	2300	CD	CD	_	34	nummod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	0000	0000	CD	CD	_	31	conj	_	_
34	hr	hr	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	6	nsubj	_	_
3	between	between	IN	IN	_	4	case	_	_
4	them	they	PRP	PRP	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	significant	significant	JJ	JJ	_	0	root	_	_
7	statistically	statistically	RB	RB	_	6	advmod	_	_
8	.	.	.	.	_	6	punct	_	_

1	2	2	LS	LS	_	15	dep	_	_
2	)	)	-RRB-	-RRB-	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	FI	fi	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	chemotactic	chemotactic	JJ	JJ	_	9	amod	_	_
8	migration	migration	NN	NN	_	9	compound	_	_
9	rate	rate	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PMN	pmn	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	cortisol	cortisol	NN	NN	_	9	nmod	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	diurnal	diurnal	JJ	JJ	_	17	amod	_	_
17	changes	change	NNS	NNS	_	15	dobj	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	were	be	VBD	VBD	_	20	cop	_	_
20	synchronous	synchronous	JJ	JJ	_	17	acl:relcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	GR	gr	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	CR	cr	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GR	gr	NN	NN	_	5	nmod	_	_
8	may	may	MD	MD	_	12	aux	_	_
9	be	be	VB	VB	_	12	cop	_	_
10	of	of	IN	IN	_	12	case	_	_
11	functional	functional	JJ	JJ	_	12	amod	_	_
12	significance	significance	NN	NN	_	2	ccomp	_	_
13	.	.	.	.	_	2	punct	_	_

1	3	3	LS	LS	_	13	dep	_	_
2	)	)	-RRB-	-RRB-	_	1	punct	_	_
3	In	in	IN	IN	_	6	case	_	_
4	Cushing	cushing	NN	NN	_	6	nmod:poss	_	_
5	's	's	POS	POS	_	6	case	_	_
6	syndrome	syndrome	NN	NN	_	13	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	CR	cr	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	GR	gr	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	normal	normal	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	spite	spite	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	fact	fact	NN	NN	_	15	nmod	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	CR	cr	NN	NN	_	26	nsubjpass	_	_
22	of	of	IN	IN	_	24	case	_	_
23	plasma	plasma	NN	NN	_	24	compound	_	_
24	cortisol	cortisol	NN	NN	_	21	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	disturbed	disturb	VBN	VBN	_	18	ccomp	_	_
27	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	independency	independency	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	CR	cr	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GR	gr	NN	NN	_	7	nmod	_	_
10	from	from	IN	IN	_	11	case	_	_
11	that	that	DT	DT	_	4	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cortisol	cortisol	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	4	4	LS	LS	_	15	dep	_	_
2	)	)	-RRB-	-RRB-	_	1	punct	_	_
3	In	in	IN	IN	_	4	case	_	_
4	apoplexy	apoplexy	NN	NN	_	15	nmod	_	_
5	caused	cause	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	brain	brain	NN	NN	_	8	compound	_	_
8	ischemia	ischemia	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	CR	cr	NN	NN	_	15	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	GR	gr	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	abolished	abolish	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	basal	basal	JJ	JJ	_	20	amod	_	_
20	lesions	lesion	NNS	NNS	_	17	nmod	_	_
21	but	but	CC	CC	_	15	cc	_	_
22	preserved	preserved	JJ	JJ	_	15	conj	_	_
23	when	when	WRB	WRB	_	27	advmod	_	_
24	the	the	DT	DT	_	25	det	_	_
25	lesions	lesion	NNS	NNS	_	27	nsubj	_	_
26	were	be	VBD	VBD	_	27	cop	_	_
27	located	located	JJ	JJ	_	22	ccomp	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	cerebral	cerebral	JJ	JJ	_	31	amod	_	_
31	cortex	cortex	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	main	main	JJ	JJ	_	10	amod	_	_
8	``	``	``	``	_	10	punct	_	_
9	circadian	circadian	JJ	JJ	_	10	amod	_	_
10	pacemaker	pacemaker	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	GR	gr	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	located	located	JJ	JJ	_	4	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	basal	basal	JJ	JJ	_	18	amod	_	_
18	brain	brain	NN	NN	_	21	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	most	most	RBS	RBS	_	21	advmod	_	_
21	probably	probably	RB	RB	_	14	advcl	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	suprachiasmatic	suprachiasmatic	JJ	JJ	_	25	amod	_	_
25	nuclei	nucleus	NNS	NNS	_	21	nmod	_	_
26	as	as	IN	IN	_	29	mark	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	suggested	suggest	VBN	VBN	_	14	advcl	_	_
30	for	for	IN	IN	_	31	case	_	_
31	rodents	rodent	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Progesterone	progesterone	NN	NN	_	2	compound	_	_
2	suppression	suppression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	pregnancy	pregnancy	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	effect	effect	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	suppressive	suppressive	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	progesterone	progesterone	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	pregnancy	pregnancy	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
15	by	by	IN	IN	_	18	case	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	progesterone	progesterone	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	competitive	competitive	JJ	JJ	_	7	amod	_	_
6	progesterone	progesterone	NN	NN	_	7	compound	_	_
7	antagonist	antagonist	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RU486	ru486	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	a	a	DT	DT	_	16	det	_	_
13	specific	specific	JJ	JJ	_	16	amod	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	blocker	blocker	NN	NN	_	7	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	RU43044	ru43044	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	tested	test	VBN	VBN	_	0	root	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	release	release	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	blocking	blocking	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	24	nmod	_	_
29	by	by	IN	IN	_	32	case	_	_
30	progesterone-treated	progesterone-treated	JJ	JJ	_	32	amod	_	_
31	pregnancy	pregnancy	NN	NN	_	32	compound	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
33	.	.	.	.	_	21	punct	_	_

1	RU	ru	NN	NN	_	11	nsubj	_	_
2	486	486	CD	CD	_	1	nummod	_	_
3	tested	test	VBN	VBN	_	1	acl	_	_
4	at	at	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	equal	equal	JJ	JJ	_	7	amod	_	_
7	concentration	concentration	NN	NN	_	3	nmod	_	_
8	as	as	IN	IN	_	9	case	_	_
9	progesterone	progesterone	NN	NN	_	7	nmod	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	blocking	blocking	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	while	while	IN	IN	_	24	mark	_	_
20	RU	ru	NN	NN	_	24	nsubj	_	_
21	43044	43044	CD	CD	_	20	nummod	_	_
22	was	be	VBD	VBD	_	24	cop	_	_
23	without	without	IN	IN	_	24	case	_	_
24	effect	effect	NN	NN	_	11	advcl	_	_
25	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	pregnancy	pregnancy	NN	NN	_	10	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	progesterone	progesterone	NN	NN	_	10	nsubj	_	_
10	acts	act	VBZ	VBZ	_	3	ccomp	_	_
11	on	on	IN	IN	_	14	case	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	progesterone	progesterone	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	21	nsubjpass	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	involved	involve	VBN	VBN	_	10	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Decreased	decrease	VBN	VBN	_	2	amod	_	_
2	concentration	concentration	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	6	compound	_	_
5	D3	d3	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	X-linked	x-linked	JJ	JJ	_	16	amod	_	_
15	hypophosphatemic	hypophosphatemic	JJ	JJ	_	16	amod	_	_
16	rickets	rickets	NN	NN	_	12	nmod	_	_
17	:	:	:	:	_	2	punct	_	_
18	effect	effect	NN	NN	_	2	dep	_	_
19	of	of	IN	IN	_	21	case	_	_
20	phosphate	phosphate	NN	NN	_	21	compound	_	_
21	supplementation	supplementation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	5	amod	_	_
2	renal	renal	JJ	JJ	_	5	amod	_	_
3	tubular	tubular	JJ	JJ	_	5	amod	_	_
4	phosphate	phosphate	NN	NN	_	5	compound	_	_
5	transport	transport	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	considered	consider	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	12	mark	_	_
9	be	be	VB	VB	_	12	cop	_	_
10	the	the	DT	DT	_	12	det	_	_
11	primary	primary	JJ	JJ	_	12	amod	_	_
12	defect	defect	NN	NN	_	7	xcomp	_	_
13	in	in	IN	IN	_	16	case	_	_
14	X-linked	x-linked	JJ	JJ	_	16	amod	_	_
15	hypophosphatemic	hypophosphatemic	JJ	JJ	_	16	amod	_	_
16	rickets	rickets	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	XLH	xlh	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	resistance	resistance	NN	NN	_	14	nsubjpass	_	_
5	to	to	TO	TO	_	8	case	_	_
6	vitamin	vitamin	NN	NN	_	8	compound	_	_
7	D	d	NN	NN	_	8	compound	_	_
8	treatment	treatment	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	XLH	xlh	NN	NN	_	4	nmod	_	_
11	can	can	MD	MD	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	explained	explain	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	hypophosphatemia	hypophosphatemia	NN	NN	_	14	nmod	_	_
17	alone	alone	RB	RB	_	16	advmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Since	since	IN	IN	_	10	mark	_	_
2	most	most	JJS	JJS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	actions	action	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	vitamin	vitamin	NN	NN	_	8	compound	_	_
8	D	d	NN	NN	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	23	advcl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	receptors	receptor	NNS	NNS	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	VDR	vdr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	23	punct	_	_
18	abnormalities	abnormality	NNS	NNS	_	23	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	VDR	vdr	NN	NN	_	18	nmod	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	postulated	postulate	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	25	case	_	_
25	XLH	xlh	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	9	advcl	_	_
5	this	this	DT	DT	_	6	det	_	_
6	possibility	possibility	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	measured	measure	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	concentration	concentration	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	VDR	vdr	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	PHA-activated	pha-activated	JJ	JJ	_	18	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	from	from	IN	IN	_	22	case	_	_
20	10	10	CD	CD	_	22	nummod	_	_
21	XLH	xlh	NN	NN	_	22	compound	_	_
22	patients	patient	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Patients	patient	NNS	NNS	_	5	nsubj	_	_
2	without	without	IN	IN	_	4	case	_	_
3	phosphate	phosphate	NN	NN	_	4	compound	_	_
4	supplementation	supplementation	NN	NN	_	1	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	lower	lower	JJR	JJR	_	8	amod	_	_
8	concentration	concentration	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	14	punct	_	_
10	21.7	21.7	CD	CD	_	14	nummod	_	_
11	+/-	+/-	CC	CC	_	10	cc	_	_
12	5.1	5.1	CD	CD	_	10	conj	_	_
13	fmol/mg	fmol/mg	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	mean	mean	NN	NN	_	14	appos	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	SEM	sem	NN	NN	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	14	punct	_	_
20	compared	compare	VBN	VBN	_	24	case	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	controls	control	NNS	NNS	_	5	advcl	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	60.7	60.7	CD	CD	_	24	dep	_	_
27	+/-	+/-	CC	CC	_	26	cc	_	_
28	4.0	4.0	CD	CD	_	26	conj	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	.	.	.	.	_	5	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	contrary	contrary	JJ	JJ	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	no	no	DT	DT	_	9	neg	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	difference	difference	NN	NN	_	6	nsubj	_	_
10	between	between	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	phosphate-supplemented	phosphate-supplemented	JJ	JJ	_	13	amod	_	_
13	patients	patient	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	58.3	58.3	CD	CD	_	13	dep	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	2.7	2.7	CD	CD	_	15	conj	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	controls	control	NNS	NNS	_	13	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	positive	positive	JJ	JJ	_	4	dep	_	_
6	correlation	correlation	NN	NN	_	2	nsubj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	VDR	vdr	NN	NN	_	9	compound	_	_
9	concentration	concentration	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	serum	serum	NN	NN	_	12	compound	_	_
12	phosphate	phosphate	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	P	p	NN	NN	_	12	dep	_	_
15	less	less	JJR	JJR	_	14	amod	_	_
16	than	than	IN	IN	_	17	case	_	_
17	0.05	0.05	CD	CD	_	15	nmod	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	patients	patient	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	VDR	vdr	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	increased	increase	VBN	VBN	_	0	root	_	_
8	after	after	IN	IN	_	13	mark	_	_
9	daily	daily	JJ	JJ	_	11	amod	_	_
10	phosphate	phosphate	NN	NN	_	11	compound	_	_
11	supplementation	supplementation	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	started	start	VBN	VBN	_	7	advcl	_	_
14	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	decreased	decrease	VBN	VBN	_	7	amod	_	_
7	concentration	concentration	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	VDR	vdr	NN	NN	_	7	nmod	_	_
10	secondary	secondary	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	persistent	persistent	JJ	JJ	_	13	amod	_	_
13	hypophosphatemia	hypophosphatemia	NN	NN	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	one	one	CD	CD	_	3	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	causes	cause	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	vitamin	vitamin	NN	NN	_	22	compound	_	_
21	D	d	NN	NN	_	22	compound	_	_
22	resistance	resistance	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	XLH	xlh	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	defensin	defensin	NN	NN	_	5	compound	_	_
4	resistance	resistance	NN	NN	_	5	compound	_	_
5	phenotypes	phenotype	NNS	NNS	_	1	nmod	_	_
6	associated	associate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	mutations	mutation	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	phoP	phop	NN	NN	_	13	compound	_	_
12	virulence	virulence	NN	NN	_	13	compound	_	_
13	regulon	regulon	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	Salmonella	salmonella	FW	FW	_	16	compound	_	_
16	typhimurium	typhimurium	FW	FW	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	defensin	defensin	NN	NN	_	3	compound	_	_
3	sensitivities	sensitivity	NNS	NNS	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Salmonella	salmonella	FW	FW	_	7	compound	_	_
6	typhimurium	typhimurium	FW	FW	_	7	compound	_	_
7	strains	strain	NNS	NNS	_	3	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	mutations	mutation	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	phoP/phoQ	phop/phoq	NN	NN	_	15	compound	_	_
13	two-component	two-component	JJ	JJ	_	15	amod	_	_
14	virulence	virulence	NN	NN	_	15	compound	_	_
15	regulon	regulon	NN	NN	_	9	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	tested	test	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	using	use	VBG	VBG	_	17	advcl	_	_
20	purified	purify	VBN	VBN	_	21	amod	_	_
21	defensins	defensin	NNS	NNS	_	19	dobj	_	_
22	NP-1	np-1	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NP-2	np-2	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	Strains	strain	NNS	NNS	_	26	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	mutations	mutation	NNS	NNS	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	either	either	DT	DT	_	6	det	_	_
6	gene	gene	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	pair	pair	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	phoP	phop	NN	NN	_	10	dep	_	_
13	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activator	activator	NN	NN	_	12	appos	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_
17	or	or	CC	CC	_	12	cc	_	_
18	phoQ	phoq	JJ	JJ	_	12	conj	_	_
19	-LSB-	-lsb-	-LRB-	-LRB-	_	22	punct	_	_
20	membrane	membrane	NN	NN	_	22	compound	_	_
21	sensor	sensor	NN	NN	_	22	compound	_	_
22	kinase	kinase	NN	NN	_	18	appos	_	_
23	-RSB-	-rsb-	-RRB-	-RRB-	_	22	punct	_	_
24	)	)	-RRB-	-RRB-	_	12	punct	_	_
25	had	have	VBD	VBD	_	26	aux	_	_
26	increased	increase	VBN	VBN	_	0	root	_	_
27	sensitivities	sensitivity	NNS	NNS	_	26	dobj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	defensin	defensin	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	predicted	predict	VBN	VBN	_	4	amod	_	_
3	periplasmic	periplasmic	JJ	JJ	_	4	amod	_	_
4	domain	domain	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	PhoQ	phoq	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	contained	contain	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	markedly	markedly	RB	RB	_	12	advmod	_	_
12	anionic	anionic	JJ	JJ	_	13	amod	_	_
13	domain	domain	NN	NN	_	9	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	could	could	MD	MD	_	16	dep	_	_
16	interact	interact	VB	VB	_	13	acl:relcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	cationic	cationic	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	that	that	WDT	WDT	_	24	nsubj	_	_
22	could	could	MD	MD	_	24	dep	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	responsible	responsible	JJ	JJ	_	16	conj	_	_
25	for	for	IN	IN	_	26	case	_	_
26	resistance	resistance	NN	NN	_	24	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	defensin	defensin	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	insertion	insertion	NN	NN	_	3	compound	_	_
3	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	phoP	phop	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	polar	polar	JJ	JJ	_	12	advcl	_	_
8	on	on	IN	IN	_	9	case	_	_
9	phoQ	phoq	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	constructed	construct	VBD	VBD	_	0	root	_	_
13	strains	strain	NNS	NNS	_	12	dobj	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	expressed	express	VBD	VBD	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	PhoQ	phoq	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	absence	absence	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	PhoP	phop	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	test	test	VB	VB	_	12	advcl	_	_
26	whether	whether	IN	IN	_	30	mark	_	_
27	resistance	resistance	NN	NN	_	30	nsubj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	defensin	defensin	NN	NN	_	27	nmod	_	_
30	requires	require	VBZ	VBZ	_	25	ccomp	_	_
31	only	only	RB	RB	_	35	advmod	_	_
32	the	the	DT	DT	_	35	det	_	_
33	phoQ	phoq	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	product	product	NN	NN	_	30	dobj	_	_
36	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	resistance	resistance	NN	NN	_	7	nsubj	_	_
5	to	to	TO	TO	_	6	case	_	_
6	defensin	defensin	NN	NN	_	4	nmod	_	_
7	requires	require	VBZ	VBZ	_	2	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	function	function	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	components	component	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	this	this	DT	DT	_	16	det	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	system	system	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	because	because	IN	IN	_	27	mark	_	_
19	strains	strain	NNS	NNS	_	27	nsubj	_	_
20	expressing	express	VBG	VBG	_	19	acl	_	_
21	PhoQ	phoq	NN	NN	_	20	dobj	_	_
22	without	without	IN	IN	_	23	case	_	_
23	PhoP	phop	NN	NN	_	20	nmod	_	_
24	were	be	VBD	VBD	_	27	cop	_	_
25	still	still	RB	RB	_	27	advmod	_	_
26	markedly	markedly	RB	RB	_	27	advmod	_	_
27	sensitive	sensitive	JJ	JJ	_	7	advcl	_	_
28	to	to	TO	TO	_	29	case	_	_
29	defensins	defensin	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	implied	imply	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	a	a	DT	DT	_	10	det	_	_
5	pag	pag	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	phoP-activated	phop-activated	JJ	JJ	_	10	amod	_	_
8	gene	gene	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	product	product	NN	NN	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	defensin	defensin	NN	NN	_	15	compound	_	_
15	resistance	resistance	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	tested	test	VBD	VBD	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ability	ability	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	defensins	defensin	NNS	NNS	_	6	nmod	_	_
9	NP-1	np-1	NN	NN	_	8	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	NP-5	np-5	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	HNP-1	HNP-1	NNP	NNP	_	9	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	activate	activate	VB	VB	_	6	acl	_	_
17	pag	pag	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	found	find	VBD	VBD	_	3	conj	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	these	these	DT	DT	_	23	det	_	_
23	peptides	peptide	NNS	NNS	_	24	nsubj	_	_
24	have	have	VBP	VBP	_	20	ccomp	_	_
25	no	no	DT	DT	_	26	neg	_	_
26	effect	effect	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Defensin	defensin	NN	NN	_	2	compound	_	_
2	resistance	resistance	NN	NN	_	8	nsubj	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	not	not	RB	RB	_	8	neg	_	_
5	the	the	DT	DT	_	8	det	_	_
6	only	only	JJ	JJ	_	8	amod	_	_
7	virulence	virulence	NN	NN	_	8	compound	_	_
8	characteristic	characteristic	NN	NN	_	0	root	_	_
9	controlled	control	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	PhoP-PhoQ	phop-phoq	JJ	JJ	_	13	amod	_	_
13	regulon	regulon	NN	NN	_	9	nmod	_	_
14	because	because	IN	IN	_	38	mark	_	_
15	mutations	mutation	NNS	NNS	_	38	nsubj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	pagC	pagc	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	as	as	RB	RB	_	15	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	ones	one	NNS	NNS	_	15	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	phoP	phop	NN	NN	_	26	compound	_	_
26	locus	locus	NN	NN	_	22	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	resulted	result	VBD	VBD	_	15	acl:relcl	_	_
29	in	in	IN	IN	_	32	case	_	_
30	constitutive	constitutive	JJ	JJ	_	32	amod	_	_
31	pag	pag	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	28	nmod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	phenotype	phenotype	NN	NN	_	35	compound	_	_
35	PhoPc	phopc	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	,	,	,	,	_	15	punct	_	_
38	had	have	VBD	VBD	_	8	advcl	_	_
39	no	no	DT	DT	_	40	neg	_	_
40	effect	effect	NN	NN	_	38	dobj	_	_
41	on	on	IN	IN	_	43	case	_	_
42	defensin	defensin	NN	NN	_	43	compound	_	_
43	resistance	resistance	NN	NN	_	38	nmod	_	_
44	,	,	,	,	_	38	punct	_	_
45	even	even	RB	RB	_	48	advmod	_	_
46	though	though	IN	IN	_	48	mark	_	_
47	they	they	PRP	PRP	_	48	nsubj	_	_
48	rendered	render	VBD	VBD	_	38	advcl	_	_
49	the	the	DT	DT	_	50	det	_	_
50	organism	organism	NN	NN	_	51	nsubj	_	_
51	avirulent	avirulent	JJ	JJ	_	48	xcomp	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	deficient	deficient	JJ	JJ	_	51	conj	_	_
54	in	in	IN	IN	_	55	case	_	_
55	survival	survival	NN	NN	_	51	dep	_	_
56	within	within	IN	IN	_	57	case	_	_
57	macrophages	macrophage	NNS	NNS	_	55	nmod	_	_
58	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	virulence	virulence	NN	NN	_	3	compound	_	_
3	defect	defect	NN	NN	_	16	nsubjpass	_	_
4	conferred	confer	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	mutations	mutation	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	phoP-phoQ	phop-phoq	JJ	JJ	_	12	amod	_	_
10	two-component	two-component	NN	NN	_	12	compound	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	6	nmod	_	_
13	is	be	VBZ	VBZ	_	16	auxpass	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	completely	completely	RB	RB	_	16	advmod	_	_
16	explained	explain	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	alterations	alteration	NNS	NNS	_	16	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	resistance	resistance	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	cationic	cationic	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	involves	involve	VBZ	VBZ	_	16	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	control	control	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	other	other	JJ	JJ	_	30	amod	_	_
30	proteins	protein	NNS	NNS	_	27	nmod	_	_
31	necessary	necessary	JJ	JJ	_	30	amod	_	_
32	for	for	IN	IN	_	35	case	_	_
33	S.	s.	FW	FW	_	35	compound	_	_
34	typhimurium	typhimurium	FW	FW	_	35	compound	_	_
35	survival	survival	NN	NN	_	31	nmod	_	_
36	within	within	IN	IN	_	37	case	_	_
37	macrophages	macrophage	NNS	NNS	_	35	nmod	_	_
38	.	.	.	.	_	16	punct	_	_

1	Adherence-dependent	adherence-dependent	JJ	JJ	_	2	amod	_	_
2	increase	increase	NN	NN	_	9	nsubjpass	_	_
3	in	in	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	monocyte	monocyte	NN	NN	_	7	compound	_	_
6	PDGF(B)	pdgf(b)	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	increases	increase	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	c-fos	c-fos	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	c-jun	c-jun	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	EGR2	egr2	NN	NN	_	13	conj	_	_
19	mRNA	mrna	NN	NN	_	13	dep	_	_
20	.	.	.	.	_	9	punct	_	_

1	Adherence	adherence	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	initial	initial	JJ	JJ	_	4	dep	_	_
6	step	step	NN	NN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transition	transition	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	circulating	circulate	VBG	VBG	_	13	amod	_	_
13	monocyte	monocyte	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	tissue	tissue	NN	NN	_	17	compound	_	_
17	macrophage	macrophage	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	differentiation	differentiation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	augmented	augmented	JJ	JJ	_	8	amod	_	_
8	capacity	capacity	NN	NN	_	4	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	generate	generate	VB	VB	_	8	acl	_	_
11	growth	growth	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	10	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	adherence	adherence	NN	NN	_	10	nsubj	_	_
5	itself	itself	PRP	PRP	_	4	nmod:npmod	_	_
6	might	might	MD	MD	_	10	aux	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	trigger	trigger	NN	NN	_	2	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	sequence	sequence	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	culminating	culminate	VBG	VBG	_	16	acl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	increased	increase	VBN	VBN	_	22	amod	_	_
22	mRNA	mrna	NN	NN	_	19	nmod	_	_
23	encoding	encode	VBG	VBG	_	22	acl	_	_
24	profibrotic	profibrotic	JJ	JJ	_	26	amod	_	_
25	growth	growth	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	dobj	_	_
27	such	such	JJ	JJ	_	33	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	platelet-derived	platelet-derived	JJ	JJ	_	33	amod	_	_
30	growth	growth	NN	NN	_	33	compound	_	_
31	factor	factor	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	subunit	subunit	NN	NN	_	26	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	PDGF-LSB-B-RSB-	pdgf-lsb-b-rsb-	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	33	cc	_	_
38	transforming	transform	VBG	VBG	_	40	amod	_	_
39	growth	growth	NN	NN	_	40	compound	_	_
40	factor-beta	factor-beta	NN	NN	_	33	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	TGF-beta	tgf-beta	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	adherence	adherence	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	8	nsubj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	biphasic	biphasic	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	PDGF(B)	pdgf(b)	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	peaks	peak	NNS	NNS	_	8	nmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	6	6	CD	CD	_	19	nummod	_	_
19	h	h	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	13	13	CD	CD	_	22	nummod	_	_
22	d	d	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	increase	increase	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	TGF-beta	tgf-beta	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	6-h	6-h	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	PDGF(B)	pdgf(b)	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	adherence	adherence	NN	NN	_	0	root	_	_
9	dependent	dependent	JJ	JJ	_	8	amod	_	_
10	,	,	,	,	_	8	punct	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	in	in	IN	IN	_	13	case	_	_
13	addition	addition	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	8	punct	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	abrogated	abrogate	VBN	VBN	_	8	conj	_	_
17	when	when	WRB	WRB	_	22	advmod	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cytoskeletal	cytoskeletal	JJ	JJ	_	20	amod	_	_
20	integrity	integrity	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	compromised	compromise	VBN	VBN	_	16	advcl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	cytochalasin	cytochalasin	NN	NN	_	25	compound	_	_
25	D	d	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	6-h	6-h	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	PDGF(B)	pdgf(b)	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	unaltered	unaltered	JJ	JJ	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	adherence	adherence	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	monocyte	monocyte	NN	NN	_	18	compound	_	_
17	stimulus	stimulus	NN	NN	_	18	compound	_	_
18	lipopolysaccharide	lipopolysaccharide	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Adherence	adherence	NN	NN	_	8	nsubj	_	_
2	to	to	TO	TO	_	4	case	_	_
3	either	either	CC	CC	_	4	cc:preconj	_	_
4	fibronectin	fibronectin	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	collagen-coated	collagen-coated	JJ	JJ	_	7	amod	_	_
7	plastic	plastic	NN	NN	_	4	conj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	little	little	JJ	JJ	_	11	amod	_	_
10	consistent	consistent	JJ	JJ	_	9	dep	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	PDGF(B)	pdgf(b)	NN	NN	_	15	compound	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	accumulation	accumulation	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	increased	increase	VBN	VBN	_	4	amod	_	_
3	PDGF(B)	pdgf(b)	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	10	nsubjpass	_	_
5	observed	observe	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	adherent	adherent	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	accompanied	accompany	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	increases	increase	NNS	NNS	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	mRNAs	mrna	NNS	NNS	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	early	early	JJ	JJ	_	20	amod	_	_
18	growth	growth	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	12	nmod	_	_
21	c-fos	c-fos	NN	NN	_	20	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	maximal	maximal	JJ	JJ	_	21	dep	_	_
24	at	at	IN	IN	_	26	case	_	_
25	20	20	CD	CD	_	26	nummod	_	_
26	min	min	NN	NN	_	23	nmod	_	_
27	)	)	-RRB-	-RRB-	_	23	punct	_	_
28	,	,	,	,	_	21	punct	_	_
29	c-jun	c-jun	NN	NN	_	21	conj	_	_
30	,	,	,	,	_	21	punct	_	_
31	and	and	CC	CC	_	21	cc	_	_
32	EGR2	egr2	NN	NN	_	21	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	maximal	maximal	JJ	JJ	_	32	dep	_	_
35	at	at	IN	IN	_	37	case	_	_
36	6-24	6-24	CD	CD	_	37	nummod	_	_
37	h	h	NN	NN	_	34	nmod	_	_
38	)	)	-RRB-	-RRB-	_	34	punct	_	_
39	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	c-jun	c-jun	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	EGR2	egr2	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	4	cc	_	_
10	c-fos	c-fos	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	mRNA	mrna	NN	NN	_	4	conj	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	abrogated	abrogate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	cytochalasin	cytochalasin	NN	NN	_	18	compound	_	_
18	D	d	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	adherence	adherence	NN	NN	_	6	nsubj	_	_
6	results	result	VBZ	VBZ	_	3	ccomp	_	_
7	in	in	IN	IN	_	8	case	_	_
8	increases	increase	NNS	NNS	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-fos	c-fos	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	c-jun	c-jun	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	EGR2	egr2	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	PDGF(B)	pdgf(b)	NN	NN	_	10	conj	_	_
18	mRNA	mrna	NN	NN	_	10	dep	_	_
19	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	increases	increase	NNS	NNS	_	14	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	c-jun	c-jun	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	EGR2	egr2	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	PDGF(B)	pdgf(b)	NN	NN	_	7	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	depend	depend	VB	VB	_	0	root	_	_
15	on	on	IN	IN	_	17	case	_	_
16	cytoskeletal	cytoskeletal	JJ	JJ	_	17	amod	_	_
17	rearrangement	rearrangement	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Modulation	modulation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	1	nmod	_	_
5	at	at	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	time	time	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	adherence	adherence	NN	NN	_	7	nmod	_	_
10	offers	offer	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	12	det	_	_
12	mechanism	mechanism	NN	NN	_	10	dobj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	22	nmod	_	_
15	differential	differential	JJ	JJ	_	16	amod	_	_
16	priming	priming	NN	NN	_	22	nsubjpass	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	accomplished	accomplish	VBN	VBN	_	12	acl:relcl	_	_
23	.	.	.	.	_	10	punct	_	_

1	NF-X2	nf-x2	NN	NN	_	10	nsubj	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	binds	bind	VBZ	VBZ	_	1	acl:relcl	_	_
4	to	to	TO	TO	_	3	dep	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DRA	dra	NN	NN	_	7	compound	_	_
7	X2-box	x2-box	NN	NN	_	4	dobj	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	activator	activator	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	0	root	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	.	.	.	.	_	10	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-Jun	c-jun	NN	NN	_	2	nmod	_	_
5	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	class	class	NN	NN	_	5	compound	_	_
3	II	ii	CD	CD	_	5	nummod	_	_
4	MHC	mhc	NN	NN	_	5	compound	_	_
5	Ag	ag	NN	NN	_	8	nsubj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	a	a	DT	DT	_	8	det	_	_
8	family	family	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	12	case	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	surface	surface	NN	NN	_	12	compound	_	_
12	glycoproteins	glycoprotein	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	constitutive	constitutive	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	limited	limited	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	thymic	thymic	JJ	JJ	_	12	amod	_	_
11	epithelial	epithelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	conj	_	_
13	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	many	many	JJ	JJ	_	4	amod	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	9	nmod	_	_
5	their	they	PRP$	PRP$	_	6	nmod:poss	_	_
6	expression	expression	NN	NN	_	9	nsubjpass	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IFN-gamma	ifn-gamma	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Conserved	conserve	VBN	VBN	_	4	amod	_	_
2	upstream	upstream	JJ	JJ	_	4	amod	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	5	nsubj	_	_
5	regulate	regulate	VBP	VBP	_	0	root	_	_
6	this	this	DT	DT	_	8	det	_	_
7	tissue-specific	tissue-specific	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	DRA	dra	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	one	one	CD	CD	_	14	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	these	these	DT	DT	_	11	det	_	_
9	cis-acting	cis-acting	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	motifs	motif	NNS	NNS	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	the	the	DT	DT	_	14	det	_	_
14	X2-box	x2-box	NN	NN	_	0	root	_	_
15	to	to	TO	TO	_	16	case	_	_
16	which	which	WDT	WDT	_	23	nmod	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	X2	x2	NN	NN	_	23	nsubj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	NF-X2	nf-x2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	binds	bind	VBZ	VBZ	_	14	acl:relcl	_	_
24	.	.	.	.	_	14	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	present	present	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	isolation	isolation	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	characterization	characterization	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	full-length	full-length	JJ	JJ	_	13	amod	_	_
12	cDNA	cdna	NN	NN	_	13	compound	_	_
13	clone	clone	NN	NN	_	6	nmod	_	_
14	encoding	encode	VBG	VBG	_	13	acl	_	_
15	NF-X2	nf-x2	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	isolated	isolate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	expression	expression	NN	NN	_	9	compound	_	_
8	cDNA	cdna	NN	NN	_	9	compound	_	_
9	cloning	cloning	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	encodes	encode	VBZ	VBZ	_	5	conj	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	c-Jun	c-jun	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	12	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	22	nsubj	_	_
19	together	together	RB	RB	_	21	advmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	c-Fos	c-fos	NN	NN	_	22	nmod	_	_
22	forms	form	VBZ	VBZ	_	16	acl:relcl	_	_
23	the	the	DT	DT	_	28	det	_	_
24	heterodimeric	heterodimeric	JJ	JJ	_	28	amod	_	_
25	activator	activator	NN	NN	_	28	compound	_	_
26	protein-1	protein-1	NN	NN	_	28	compound	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	22	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	3	compound	_	_
3	heterodimers	heterodimer	NNS	NNS	_	6	nsubj	_	_
4	do	do	VBP	VBP	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	exist	exist	VB	VB	_	12	advcl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	they	they	PRP	PRP	_	12	nsubj	_	_
12	form	form	VBP	VBP	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	bind	bind	VBP	VBP	_	12	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	X2-box	x2-box	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	class	class	NN	NN	_	22	compound	_	_
20	II	ii	CD	CD	_	22	nummod	_	_
21	nonexpressing	nonexpressing	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	4	compound	_	_
4	heterodimers	heterodimer	NNS	NNS	_	6	nsubj	_	_
5	might	might	MD	MD	_	6	aux	_	_
6	contribute	contribute	VB	VB	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	repression	repression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	DRA	dra	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	2	amod	_	_
2	study	study	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	steroid	steroid	NN	NN	_	5	compound	_	_
5	hormones	hormone	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	an	a	DT	DT	_	10	det	_	_
8	estrogen	estrogen	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	2	conj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	malignant	malignant	JJ	JJ	_	15	amod	_	_
13	soft	soft	JJ	JJ	_	15	amod	_	_
14	tissue	tissue	NN	NN	_	15	compound	_	_
15	tumors	tumor	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Immunohistochemically	immunohistochemically	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	immunoreaction	immunoreaction	NN	NN	_	22	nsubjpass	_	_
5	against	against	IN	IN	_	9	case	_	_
6	5	5	CD	CD	_	9	nummod	_	_
7	steroid	steroid	NN	NN	_	9	compound	_	_
8	hormone	hormone	NN	NN	_	9	compound	_	_
9	anti-sera	anti-serum	NNS	NNS	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	estradiol	estradiol	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	estriol	estriol	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	cortisol	cortisol	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	progesterone	progesterone	NN	NN	_	11	conj	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	testosterone	testosterone	NN	NN	_	11	conj	_	_
20	)	)	-RRB-	-RRB-	_	11	punct	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	examined	examine	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	39	39	CD	CD	_	25	nummod	_	_
25	cases	case	NNS	NNS	_	22	nmod	_	_
26	with	with	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	malignant	malignant	JJ	JJ	_	31	amod	_	_
29	soft	soft	JJ	JJ	_	31	amod	_	_
30	tissue	tissue	NN	NN	_	31	compound	_	_
31	tumors	tumor	NNS	NNS	_	25	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	fibrosarcoma	fibrosarcoma	NN	NN	_	25	dep	_	_
34	:	:	:	:	_	33	punct	_	_
35	8	8	CD	CD	_	33	dep	_	_
36	,	,	,	,	_	33	punct	_	_
37	malignant	malignant	JJ	JJ	_	39	amod	_	_
38	fibrous	fibrous	JJ	JJ	_	37	dep	_	_
39	histiocytoma	histiocytoma	NN	NN	_	33	appos	_	_
40	:	:	:	:	_	39	punct	_	_
41	6	6	CD	CD	_	39	dep	_	_
42	,	,	,	,	_	33	punct	_	_
43	rhabdomyosarcoma	rhabdomyosarcoma	NN	NN	_	33	appos	_	_
44	:	:	:	:	_	43	punct	_	_
45	10	10	CD	CD	_	43	dep	_	_
46	,	,	,	,	_	33	punct	_	_
47	leiomyosarcoma	leiomyosarcoma	NN	NN	_	33	appos	_	_
48	:	:	:	:	_	47	punct	_	_
49	10	10	CD	CD	_	47	dep	_	_
50	,	,	,	,	_	33	punct	_	_
51	liposarcoma	liposarcoma	NN	NN	_	33	appos	_	_
52	:	:	:	:	_	51	punct	_	_
53	5	5	CD	CD	_	51	dep	_	_
54	)	)	-RRB-	-RRB-	_	33	punct	_	_
55	.	.	.	.	_	22	punct	_	_

1	Seventeen	seventeen	CD	CD	_	2	nummod	_	_
2	cases	case	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	immunostaining	immunostaining	NN	NN	_	3	dobj	_	_
6	against	against	IN	IN	_	9	case	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	1	1	CD	CD	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	5	5	CD	CD	_	14	nummod	_	_
13	steroid	steroid	NN	NN	_	14	compound	_	_
14	hormones	hormone	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Immunostained	immunostain	VBN	VBN	_	3	amod	_	_
2	tumor	tumor	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
4	were	be	VBD	VBD	_	7	auxpass	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	frequently	frequently	RB	RB	_	7	advmod	_	_
7	distributed	distribute	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	area	area	NN	NN	_	7	nmod	_	_
11	where	where	WRB	WRB	_	17	advmod	_	_
12	tumor	tumor	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	infiltration	infiltration	NN	NN	_	17	nsubj	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	invasive	invasive	JJ	JJ	_	10	acl:relcl	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	majority	majority	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	positive	positive	JJ	JJ	_	6	amod	_	_
6	cases	case	NNS	NNS	_	2	nmod	_	_
7	occurred	occur	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	female	female	JJ	JJ	_	10	amod	_	_
10	cases	case	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	existence	existence	NN	NN	_	14	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	estrogen	estrogen	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	estrogen	estrogen	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	examined	examine	VBN	VBN	_	0	root	_	_
15	histochemically	histochemically	RB	RB	_	14	advmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	39	39	CD	CD	_	18	nummod	_	_
18	cases	case	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	it	it	PRP	PRP	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	detected	detect	VBN	VBN	_	14	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	8	8	CD	CD	_	22	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	concluded	conclude	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	steroid	steroid	NN	NN	_	5	compound	_	_
5	hormones	hormone	NNS	NNS	_	9	nsubj	_	_
6	might	might	MD	MD	_	9	aux	_	_
7	be	be	VB	VB	_	9	cop	_	_
8	closely	closely	RB	RB	_	9	advmod	_	_
9	related	related	JJ	JJ	_	2	ccomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	tumor	tumor	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	infiltration	infiltration	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	some	some	DT	DT	_	19	det	_	_
16	malignant	malignant	JJ	JJ	_	19	amod	_	_
17	soft	soft	JJ	JJ	_	19	amod	_	_
18	tissue	tissue	NN	NN	_	19	compound	_	_
19	tumors	tumor	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	5	det	_	_
4	sexual	sexual	JJ	JJ	_	5	amod	_	_
5	dimorphism	dimorphism	NN	NN	_	1	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	autoimmunity	autoimmunity	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	sexual	sexual	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	11	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	incidence	incidence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	autoimmune	autoimmune	JJ	JJ	_	9	amod	_	_
9	diseases	disease	NNS	NNS	_	6	nmod	_	_
10	has	have	VBZ	VBZ	_	11	aux	_	_
11	remained	remain	VBN	VBN	_	0	root	_	_
12	an	a	DT	DT	_	13	det	_	_
13	enigma	enigma	NN	NN	_	11	xcomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	years	year	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	examination	examination	NN	NN	_	16	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	induction	induction	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	autoimmunity	autoimmunity	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	transgenic	transgenic	JJ	JJ	_	11	amod	_	_
11	mice	mouse	NNS	NNS	_	3	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	evidence	evidence	NN	NN	_	16	nsubjpass	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	obtained	obtain	VBN	VBN	_	0	root	_	_
17	further	further	JJ	JJ	_	16	advmod	_	_
18	implicating	implicate	VBG	VBG	_	16	dep	_	_
19	the	the	DT	DT	_	20	det	_	_
20	lymphokine	lymphokine	NN	NN	_	18	dobj	_	_
21	interferon-gamma	interferon-gamma	NN	NN	_	20	dep	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	etiology	etiology	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	autoimmunity	autoimmunity	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Sex	sex	NN	NN	_	3	compound	_	_
2	steroid	steroid	NN	NN	_	3	compound	_	_
3	regulation	regulation	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	production	production	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	molecule	molecule	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	as	as	RB	RB	_	9	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	9	conj	_	_
16	,	,	,	,	_	3	punct	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	help	help	VB	VB	_	0	root	_	_
19	explain	explain	VB	VB	_	18	ccomp	_	_
20	the	the	DT	DT	_	22	det	_	_
21	gender-specific	gender-specific	JJ	JJ	_	22	amod	_	_
22	differences	difference	NNS	NNS	_	19	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	including	include	VBG	VBG	_	29	case	_	_
29	autoimmunity	autoimmunity	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	mitogen-inducible	mitogen-inducible	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	a	a	DT	DT	_	11	det	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	6	dobj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	homology	homology	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	rel	rel	NN	NN	_	17	compound	_	_
17	oncogene	oncogene	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	to	to	TO	TO	_	21	case	_	_
20	cell-cycle	cell-cycle	JJ	JJ	_	21	amod	_	_
21	motifs	motif	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	characterized	characterize	VBN	VBN	_	3	conj	_	_
6	a	a	DT	DT	_	8	det	_	_
7	mitogen-inducible	mitogen-inducible	JJ	JJ	_	8	amod	_	_
8	gene	gene	NN	NN	_	3	dobj	_	_
9	isolated	isolate	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	predicts	predict	VBZ	VBZ	_	8	acl:relcl	_	_
16	a	a	DT	DT	_	17	det	_	_
17	protein	protein	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	968	968	CD	CD	_	21	nummod	_	_
20	amino	amino	NN	NN	_	21	compound	_	_
21	acids	acid	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	amino-terminal	amino-terminal	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	regions	region	NNS	NNS	_	4	dobj	_	_
6	homologous	homologous	JJ	JJ	_	5	amod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	oncogene	oncogene	NN	NN	_	10	compound	_	_
10	rel	rel	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	developmentally	developmentally	RB	RB	_	15	advmod	_	_
15	important	important	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	dorsal	dorsal	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Drosophila	drosophila	FW	FW	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	carboxy-terminal	carboxy-terminal	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	repeat	repeat	NN	NN	_	6	compound	_	_
6	structures	structure	NNS	NNS	_	4	dobj	_	_
7	found	find	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	proteins	protein	NNS	NNS	_	10	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	6	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	cell-cycle	cell-cycle	JJ	JJ	_	18	amod	_	_
18	control	control	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	yeast	yeast	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	in	in	IN	IN	_	24	case	_	_
23	tissue	tissue	NN	NN	_	24	compound	_	_
24	differentiation	differentiation	NN	NN	_	18	conj	_	_
25	in	in	IN	IN	_	26	case	_	_
26	Drosophila	drosophila	FW	FW	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	Ceanorhabditis	ceanorhabditis	FW	FW	_	29	compound	_	_
29	elegans	elegans	FW	FW	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	as	as	RB	RB	_	26	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	in	in	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	putative	putative	JJ	JJ	_	39	amod	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	oncogene	oncogene	NN	NN	_	39	compound	_	_
39	bcl-3	bcl-3	NN	NN	_	26	conj	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	in	in	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	ankyrin	ankyrin	NN	NN	_	44	compound	_	_
44	protein	protein	NN	NN	_	39	conj	_	_
45	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	truncated	truncated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	product	product	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	gene	gene	NN	NN	_	6	nmod	_	_
10	translated	translate	VBN	VBN	_	9	acl	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	10	advmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	DNA-binding	dna-binding	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	0	root	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	interacts	interact	VBZ	VBZ	_	16	acl:relcl	_	_
19	specifically	specifically	RB	RB	_	18	advmod	_	_
20	with	with	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	kappa	kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	18	nmod	_	_
26	found	find	VBN	VBN	_	25	acl	_	_
27	in	in	IN	IN	_	30	case	_	_
28	many	many	JJ	JJ	_	30	amod	_	_
29	inducible	inducible	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	26	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	including	include	VBG	VBG	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	enhancer	enhancer	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	human	human	JJ	JJ	_	38	amod	_	_
37	immunodeficiency	immunodeficiency	NN	NN	_	38	compound	_	_
38	virus	virus	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	yet	yet	RB	RB	_	5	advmod	_	_
5	another	another	DT	DT	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	growing	grow	VBG	VBG	_	9	amod	_	_
9	list	list	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	important	important	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	11	dep	_	_
13	molecules	molecule	NNS	NNS	_	9	nmod	_	_
14	whose	whose	WP$	WP$	_	15	nmod:poss	_	_
15	expression	expression	NN	NN	_	18	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	transcriptionally	transcriptionally	RB	RB	_	18	advmod	_	_
18	induced	induce	VBN	VBN	_	13	ccomp	_	_
19	upon	upon	IN	IN	_	21	case	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	clone	clone	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	anti-CD3	anti-cd3	JJ	JJ	_	1	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	tumor	tumor	NN	NN	_	12	compound	_	_
11	necrosis	necrosis	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	8	conj	_	_
13	induces	induce	VBZ	VBZ	_	0	root	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	translocation	translocation	NN	NN	_	13	dobj	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	human	human	JJ	JJ	_	24	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	24	compound	_	_
21	virus	virus	NN	NN	_	24	compound	_	_
22	1	1	CD	CD	_	24	nummod	_	_
23	enhancer-dependent	enhancer-dependent	JJ	JJ	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	16	conj	_	_
25	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	42	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	transiently	transiently	RB	RB	_	5	advmod	_	_
5	transfected	transfect	VBN	VBN	_	7	amod	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	vectors	vector	NNS	NNS	_	2	nmod	_	_
8	under	under	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	control	control	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	repeat	repeat	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LTR	ltr	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	immunodeficiency	immunodeficiency	NN	NN	_	23	compound	_	_
23	virus	virus	NN	NN	_	15	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	HIV	hiv	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	15	cc	_	_
28	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
29	enhancer	enhancer	NN	NN	_	30	compound	_	_
30	sequence	sequence	NN	NN	_	15	conj	_	_
31	and	and	CC	CC	_	2	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	translocation	translocation	NN	NN	_	2	conj	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	HIV	hiv	NN	NN	_	38	compound	_	_
37	enhancer-binding	enhancer-binding	JJ	JJ	_	38	amod	_	_
38	protein	protein	NN	NN	_	33	nmod	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	38	dep	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	analyzed	analyze	VBN	VBN	_	0	root	_	_
43	in	in	IN	IN	_	47	case	_	_
44	two	two	CD	CD	_	47	nummod	_	_
45	human	human	JJ	JJ	_	47	amod	_	_
46	T-cell	t-cell	NN	NN	_	47	compound	_	_
47	clones	clone	NNS	NNS	_	42	nmod	_	_
48	stimulated	stimulate	VBN	VBN	_	47	acl	_	_
49	through	through	IN	IN	_	53	case	_	_
50	their	they	PRP$	PRP$	_	53	nmod:poss	_	_
51	T-cell	t-cell	NN	NN	_	53	compound	_	_
52	receptor	receptor	NN	NN	_	53	compound	_	_
53	complex	complex	NN	NN	_	48	nmod	_	_
54	or	or	CC	CC	_	53	cc	_	_
55	by	by	IN	IN	_	58	case	_	_
56	tumor	tumor	NN	NN	_	58	compound	_	_
57	necrosis	necrosis	NN	NN	_	58	compound	_	_
58	factor	factor	NN	NN	_	53	conj	_	_
59	or	or	CC	CC	_	58	cc	_	_
60	phorbol	phorbol	NN	NN	_	62	compound	_	_
61	12-myristate	12-myristate	NN	NN	_	62	compound	_	_
62	13-acetate	13-acetate	NN	NN	_	58	conj	_	_
63	.	.	.	.	_	42	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	dissociation	dissociation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	translocation	translocation	NN	NN	_	4	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	transactivation	transactivation	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	either	either	CC	CC	_	15	cc:preconj	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	LTR	ltr	NN	NN	_	10	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	enhancer	enhancer	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	Interleukin	interleukin	NN	NN	_	3	nsubj	_	_
2	2	2	CD	CD	_	1	nummod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	proliferation	proliferation	NN	NN	_	3	dobj	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	4	cc	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	translocation	translocation	NN	NN	_	4	conj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	LTR	ltr	NN	NN	_	12	compound	_	_
12	transactivation	transactivation	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	3	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	ester	ester	NN	NN	_	7	nsubj	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	specific	specific	JJ	JJ	_	6	amod	_	_
5	antigen	antigen	NN	NN	_	6	compound	_	_
6	recognition	recognition	NN	NN	_	2	conj	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	HIV	hiv	NN	NN	_	10	compound	_	_
9	LTR	ltr	NN	NN	_	10	compound	_	_
10	transactivation	transactivation	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	whereas	whereas	IN	IN	_	22	mark	_	_
13	stimulation	stimulation	NN	NN	_	22	nsubj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	necrosis	necrosis	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	antibody	antibody	NN	NN	_	17	conj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	CD3	cd3	NN	NN	_	19	nmod	_	_
22	did	do	VBD	VBD	_	7	advcl	_	_
23	not	not	RB	RB	_	22	neg	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	latter	latter	JJ	JJ	_	4	amod	_	_
4	signals	signal	NNS	NNS	_	7	nsubj	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	nevertheless	nevertheless	RB	RB	_	7	advmod	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	translocation	translocation	NN	NN	_	9	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	pattern	pattern	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	band-shift	band-shift	JJ	JJ	_	19	amod	_	_
19	assay	assay	NN	NN	_	15	nmod	_	_
20	indistinguishable	indistinguishable	JJ	JJ	_	19	amod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	observed	observe	VBN	VBN	_	22	acl	_	_
24	using	use	VBG	VBG	_	7	xcomp	_	_
25	phorbol	phorbol	NN	NN	_	26	compound	_	_
26	ester	ester	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	finding	finding	NN	NN	_	28	nsubj	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	induction	induction	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	4	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	antibody	antibody	NN	NN	_	15	compound	_	_
14	to	to	TO	TO	_	15	dep	_	_
15	CD3	cd3	NN	NN	_	11	conj	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	sufficient	sufficient	JJ	JJ	_	2	ccomp	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	induce	induce	VB	VB	_	18	xcomp	_	_
21	HIV	hiv	NN	NN	_	23	compound	_	_
22	enhancer-dependent	enhancer-dependent	JJ	JJ	_	23	amod	_	_
23	transcription	transcription	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	cloned	clone	VBN	VBN	_	20	advcl	_	_
26	T	t	NN	NN	_	25	dep	_	_
27	cells	cell	NNS	NNS	_	25	dep	_	_
28	contrasts	contrast	VBZ	VBZ	_	0	root	_	_
29	with	with	IN	IN	_	30	case	_	_
30	results	result	NNS	NNS	_	28	nmod	_	_
31	obtained	obtain	VBN	VBN	_	30	acl	_	_
32	in	in	IN	IN	_	36	case	_	_
33	most	most	JJS	JJS	_	36	amod	_	_
34	lymphoblastoid	lymphoblastoid	JJ	JJ	_	36	amod	_	_
35	T-cell	t-cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	31	nmod	_	_
37	and	and	CC	CC	_	28	cc	_	_
38	indicates	indicate	VBZ	VBZ	_	28	conj	_	_
39	that	that	IN	IN	_	43	mark	_	_
40	normal	normal	JJ	JJ	_	42	amod	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	lymphocytes	lymphocyte	NNS	NNS	_	43	nsubj	_	_
43	differ	differ	VBP	VBP	_	38	ccomp	_	_
44	from	from	IN	IN	_	47	case	_	_
45	tumoral	tumoral	JJ	JJ	_	47	amod	_	_
46	T	t	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	43	nmod	_	_
48	in	in	IN	IN	_	49	case	_	_
49	terms	term	NNS	NNS	_	43	nmod	_	_
50	of	of	IN	IN	_	51	case	_	_
51	requirements	requirement	NNS	NNS	_	49	nmod	_	_
52	for	for	IN	IN	_	55	case	_	_
53	HIV	hiv	NN	NN	_	55	compound	_	_
54	LTR	ltr	NN	NN	_	55	compound	_	_
55	activation	activation	NN	NN	_	51	nmod	_	_
56	.	.	.	.	_	28	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	events	event	NNS	NNS	_	22	nsubj	_	_
8	linked	link	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	addition	addition	NN	NN	_	7	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	translocation	translocation	NN	NN	_	14	nmod	_	_
19	per	per	FW	FW	_	20	compound	_	_
20	se	se	FW	FW	_	18	dep	_	_
21	,	,	,	,	_	7	punct	_	_
22	induce	induce	VBP	VBP	_	5	ccomp	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	interactions	interaction	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	complex	complex	NN	NN	_	24	nmod	_	_
30	with	with	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	HIV	hiv	NN	NN	_	33	compound	_	_
33	enhancer	enhancer	NN	NN	_	24	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	double-stranded	double-stranded	JJ	JJ	_	8	amod	_	_
7	phosphorothioate	phosphorothioate	NN	NN	_	8	compound	_	_
8	oligonucleotides	oligonucleotide	NNS	NNS	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Alteration	alteration	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	transcription	transcription	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	inhibition	inhibition	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	specific	specific	JJ	JJ	_	11	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	necessary	necessary	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	15	mark	_	_
15	determining	determine	VBG	VBG	_	13	advcl	_	_
16	how	how	WRB	WRB	_	19	advmod	_	_
17	these	these	DT	DT	_	18	det	_	_
18	factors	factor	NNS	NNS	_	19	nsubj	_	_
19	participate	participate	VBP	VBP	_	15	ccomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	cellular	cellular	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	functions	function	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	antagonized	antagonize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	methods	method	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	each	each	DT	DT	_	11	appos	_	_
14	with	with	IN	IN	_	16	case	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	limitations	limitation	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	sequence-specific	sequence-specific	JJ	JJ	_	5	amod	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	achieved	achieve	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	14	case	_	_
9	double-stranded	double-stranded	JJ	JJ	_	14	amod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ds	ds	JJ	JJ	_	9	dep	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	phosphorothioate	phosphorothioate	NN	NN	_	14	compound	_	_
14	oligonucleotides	oligonucleotide	NNS	NNS	_	7	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	contained	contain	VBD	VBD	_	14	acl:relcl	_	_
17	octamer	octamer	NN	NN	_	16	dobj	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	conj	_	_
21	consensus	consensus	NN	NN	_	22	compound	_	_
22	sequences	sequence	NNS	NNS	_	17	dep	_	_
23	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	phosphorothioate	phosphorothioate	NN	NN	_	3	compound	_	_
3	oligonucleotides	oligonucleotide	NNS	NNS	_	5	nsubj	_	_
4	specifically	specifically	RB	RB	_	5	advmod	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	either	either	CC	CC	_	9	cc:preconj	_	_
7	octamer	octamer	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	5	dobj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
12	factor	factor	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	NF	nf	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	-kappa	-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	9	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	modified	modify	VBN	VBN	_	3	amod	_	_
3	oligonucleotides	oligonucleotide	NNS	NNS	_	4	nsubj	_	_
4	accumulated	accumulate	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	4	nmod	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	effectively	effectively	RB	RB	_	4	advmod	_	_
9	than	than	IN	IN	_	12	mark	_	_
10	standard	standard	JJ	JJ	_	12	amod	_	_
11	ds	ds	JJ	JJ	_	12	amod	_	_
12	oligonucleotides	oligonucleotide	NNS	NNS	_	8	advcl	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	modulated	modulate	VBD	VBD	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	specific	specific	JJ	JJ	_	20	amod	_	_
20	manner	manner	NN	NN	_	12	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	Octamer-dependent	octamer-dependent	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	plasmid	plasmid	NN	NN	_	2	nmod	_	_
7	or	or	CC	CC	_	2	cc	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B-dependent	b-dependent	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	2	conj	_	_
11	of	of	IN	IN	_	19	case	_	_
12	the	the	DT	DT	_	19	det	_	_
13	human	human	JJ	JJ	_	19	amod	_	_
14	immunodeficiency	immunodeficiency	NN	NN	_	19	compound	_	_
15	virus	virus	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	HIV	hiv	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	enhancer	enhancer	NN	NN	_	10	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	inhibited	inhibit	VBN	VBN	_	0	root	_	_
22	when	when	WRB	WRB	_	28	advmod	_	_
23	the	the	DT	DT	_	26	det	_	_
24	appropriate	appropriate	JJ	JJ	_	26	amod	_	_
25	phosphorothioate	phosphorothioate	NN	NN	_	26	compound	_	_
26	oligonucleotide	oligonucleotide	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	added	add	VBN	VBN	_	21	advcl	_	_
29	to	to	TO	TO	_	35	case	_	_
30	a	a	DT	DT	_	35	det	_	_
31	transiently	transiently	RB	RB	_	35	advmod	_	_
32	transfected	transfect	VBN	VBN	_	35	amod	_	_
33	B	b	NN	NN	_	35	compound	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	line	line	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	21	punct	_	_

1	Addition	addition	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	phosphorothioate	phosphorothioate	NN	NN	_	4	compound	_	_
4	oligonucleotides	oligonucleotide	NNS	NNS	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	contained	contain	VBD	VBD	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	octamer	octamer	NN	NN	_	9	compound	_	_
9	consensus	consensus	NN	NN	_	6	dobj	_	_
10	to	to	TO	TO	_	14	case	_	_
11	Jurkat	jurkat	NN	NN	_	14	compound	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	1	nmod	_	_
15	inhibited	inhibit	VBD	VBD	_	0	root	_	_
16	interleukin-2	interleukin-2	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL-2	il-2	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	secretion	secretion	NN	NN	_	15	dobj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	degree	degree	NN	NN	_	15	nmod	_	_
24	similar	similar	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	that	that	DT	DT	_	24	nmod	_	_
27	observed	observe	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	32	case	_	_
29	a	a	DT	DT	_	32	det	_	_
30	mutated	mutate	VBN	VBN	_	32	amod	_	_
31	octamer	octamer	NN	NN	_	32	compound	_	_
32	site	site	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	IL-2	il-2	NN	NN	_	36	compound	_	_
36	enhancer	enhancer	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ds	ds	JJ	JJ	_	4	amod	_	_
3	phosphorothioate	phosphorothioate	NN	NN	_	4	compound	_	_
4	oligonucleotides	oligonucleotide	NNS	NNS	_	6	nsubj	_	_
5	probably	probably	RB	RB	_	6	advmod	_	_
6	compete	compete	VBP	VBP	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	binding	binding	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	provide	provide	VB	VB	_	6	conj	_	_
16	anti-viral	anti-viral	JJ	JJ	_	15	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	immunosuppressive	immunosuppressive	JJ	JJ	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	therapeutic	therapeutic	JJ	JJ	_	16	conj	_	_
23	effects	effect	NNS	NNS	_	16	dep	_	_
24	.	.	.	.	_	6	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	The	the	DT	DT	_	3	det	_	_
3	effect	effect	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	24,25-dihydroxyvitamin	24,25-dihydroxyvitamin	NN	NN	_	6	compound	_	_
6	D3	d3	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	dioxyvit	dioxyvit	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	on	on	IN	IN	_	12	case	_	_
11	Ca	ca	NN	NN	_	12	compound	_	_
12	metabolism	metabolism	NN	NN	_	3	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	status	status	NN	NN	_	12	conj	_	_
16	during	during	IN	IN	_	19	case	_	_
17	chronic	chronic	JJ	JJ	_	19	amod	_	_
18	kidney	kidney	NN	NN	_	19	compound	_	_
19	failure	failure	NN	NN	_	3	nmod	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Active	active	JJ	JJ	_	2	amod	_	_
2	metabolite	metabolite	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	vitamin	vitamin	NN	NN	_	7	compound	_	_
5	D3	d3	NN	NN	_	7	compound	_	_
6	,	,	,	,	_	7	punct	_	_
7	24R,25(OH)2D3	24r,25(oh)2d3	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	dioxyvit	dioxyvit	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	at	at	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	daily	daily	JJ	JJ	_	16	amod	_	_
16	dose	dose	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	100	100	CD	CD	_	19	nummod	_	_
19	micrograms	microgram	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	treatment	treatment	NN	NN	_	12	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	children	child	NNS	NNS	_	21	nmod	_	_
24	affected	affect	VBN	VBN	_	23	acl	_	_
25	with	with	IN	IN	_	27	case	_	_
26	tubulointerstitial	tubulointerstitial	JJ	JJ	_	27	amod	_	_
27	disease	disease	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	kidney	kidney	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	with	with	IN	IN	_	33	case	_	_
32	chronic	chronic	JJ	JJ	_	33	amod	_	_
33	glomerulonephritis	glomerulonephritis	NN	NN	_	27	conj	_	_
34	under	under	IN	IN	_	35	case	_	_
35	conditions	condition	NNS	NNS	_	24	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	kidney	kidney	NN	NN	_	38	compound	_	_
38	insufficiency	insufficiency	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	drug	drug	NN	NN	_	3	nsubj	_	_
3	exhibited	exhibit	VBD	VBD	_	0	root	_	_
4	distinct	distinct	JJ	JJ	_	6	amod	_	_
5	normalizing	normalizing	NN	NN	_	6	compound	_	_
6	effect	effect	NN	NN	_	3	dobj	_	_
7	on	on	IN	IN	_	8	case	_	_
8	patterns	pattern	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	calcium	calcium	NN	NN	_	11	compound	_	_
11	metabolism	metabolism	NN	NN	_	8	nmod	_	_
12	:	:	:	:	_	3	punct	_	_
13	increase	increase	NN	NN	_	3	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	total	total	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	ionized	ionize	VBN	VBN	_	15	conj	_	_
18	Ca2+	ca2+	NN	NN	_	15	dep	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	of	of	IN	IN	_	21	case	_	_
21	25-OHD	25-ohd	NN	NN	_	15	conj	_	_
22	,	,	,	,	_	13	punct	_	_
23	decrease	decrease	NN	NN	_	13	appos	_	_
24	in	in	IN	IN	_	25	case	_	_
25	concentration	concentration	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	parath	parath	NN	NN	_	28	compound	_	_
28	hormone	hormone	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	osteocalcine	osteocalcine	NN	NN	_	28	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	blood	blood	NN	NN	_	33	compound	_	_
33	serum	serum	NN	NN	_	25	nmod	_	_
34	as	as	RB	RB	_	33	cc	_	_
35	well	well	RB	RB	_	34	mwe	_	_
36	as	as	IN	IN	_	34	mwe	_	_
37	on	on	IN	IN	_	39	case	_	_
38	immunological	immunological	JJ	JJ	_	39	amod	_	_
39	parameters	parameter	NNS	NNS	_	33	conj	_	_
40	:	:	:	:	_	13	punct	_	_
41	restoration	restoration	NN	NN	_	13	dep	_	_
42	of	of	IN	IN	_	44	case	_	_
43	decreased	decrease	VBN	VBN	_	44	amod	_	_
44	content	content	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	T-	t-	NN	NN	_	44	nmod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	0-lymphocytes	0-lymphocyte	NNS	NNS	_	46	conj	_	_
49	.	.	.	.	_	3	punct	_	_

1	Concentration	concentration	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	receptors	receptor	NNS	NNS	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	hormonal	hormonal	JJ	JJ	_	6	amod	_	_
6	form	form	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	minimal	minimal	JJ	JJ	_	10	xcomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
16	under	under	IN	IN	_	17	case	_	_
17	conditions	condition	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	chronic	chronic	JJ	JJ	_	21	amod	_	_
20	kidney	kidney	NN	NN	_	21	compound	_	_
21	insufficiency	insufficiency	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	while	while	IN	IN	_	33	mark	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	expression	expression	NN	NN	_	33	nsubjpass	_	_
26	,	,	,	,	_	25	punct	_	_
27	after	after	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	dioxyvit	dioxyvit	NN	NN	_	30	compound	_	_
30	action	action	NN	NN	_	33	nmod	_	_
31	,	,	,	,	_	33	punct	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	detected	detect	VBN	VBN	_	10	advcl	_	_
34	only	only	RB	RB	_	36	advmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	patients	patient	NNS	NNS	_	33	nmod	_	_
37	with	with	IN	IN	_	38	case	_	_
38	glomerulonephritis	glomerulonephritis	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	calcitropic	calcitropic	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	dioxyvit	dioxyvit	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	simultaneous	simultaneous	JJ	JJ	_	8	amod	_	_
8	correction	correction	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	vitamin	vitamin	NN	NN	_	12	compound	_	_
11	D	d	NN	NN	_	12	compound	_	_
12	deficiency	deficiency	NN	NN	_	8	nmod	_	_
13	were	be	VBD	VBD	_	15	cop	_	_
14	apparently	apparently	RB	RB	_	15	advmod	_	_
15	responsible	responsible	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	efficacy	efficacy	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	drug	drug	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	treatment	treatment	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	calcium	calcium	NN	NN	_	26	compound	_	_
26	metabolism	metabolism	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	immunity	immunity	NN	NN	_	29	compound	_	_
29	impairments	impairment	NNS	NNS	_	26	conj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	children	child	NNS	NNS	_	26	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	renal	renal	JJ	JJ	_	34	amod	_	_
34	deteriorations	deterioration	NNS	NNS	_	31	nmod	_	_
35	at	at	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	step	step	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	chronic	chronic	JJ	JJ	_	41	amod	_	_
40	kidney	kidney	NN	NN	_	41	compound	_	_
41	insufficiency	insufficiency	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	15	punct	_	_

1	Extrarenal	extrarenal	JJ	JJ	_	2	amod	_	_
2	receptor-effector-mechanisms	receptor-effector-mechanism	NNS	NNS	_	0	root	_	_
3	for	for	IN	IN	_	4	case	_	_
4	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	sequence	sequence	NN	NN	_	2	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	effects	effect	NNS	NNS	_	7	nmod	_	_
10	on	on	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	cellular	cellular	JJ	JJ	_	14	amod	_	_
13	electrolyte	electrolyte	NN	NN	_	14	compound	_	_
14	transport	transport	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	implications	implication	NNS	NNS	_	7	conj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	disorders	disorder	NNS	NNS	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	water	water	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	electrolyte	electrolyte	NN	NN	_	25	conj	_	_
28	balances	balance	NNS	NNS	_	25	dep	_	_
29	.	.	.	.	_	2	punct	_	_

1	High	high	JJ	JJ	_	5	amod	_	_
2	affinity	affinity	NN	NN	_	5	compound	_	_
3	aldosterone	aldosterone	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	6	nsubj	_	_
6	have	have	VBP	VBP	_	0	root	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	only	only	RB	RB	_	6	dep	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	described	describe	VBN	VBN	_	6	conj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	classic	classic	JJ	JJ	_	15	amod	_	_
14	target	target	NN	NN	_	15	compound	_	_
15	tissues	tissue	NNS	NNS	_	10	nmod	_	_
16	such	such	JJ	JJ	_	20	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	the	the	DT	DT	_	20	det	_	_
19	renal	renal	JJ	JJ	_	20	amod	_	_
20	tubules	tubule	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	but	but	CC	CC	_	15	cc	_	_
23	also	also	RB	RB	_	27	advmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	non-classic	non-classic	JJ	JJ	_	27	amod	_	_
26	target	target	NN	NN	_	27	compound	_	_
27	tissues	tissue	NNS	NNS	_	15	conj	_	_
28	such	such	JJ	JJ	_	31	case	_	_
29	as	as	IN	IN	_	28	mwe	_	_
30	the	the	DT	DT	_	31	det	_	_
31	hippocampus	hippocampus	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	mammary	mammary	JJ	JJ	_	34	amod	_	_
34	gland	gland	NN	NN	_	31	conj	_	_
35	,	,	,	,	_	31	punct	_	_
36	endothelial	endothelial	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	31	conj	_	_
38	and	and	CC	CC	_	31	cc	_	_
39	,	,	,	,	_	31	punct	_	_
40	recently	recently	RB	RB	_	31	advmod	_	_
41	,	,	,	,	_	31	punct	_	_
42	human	human	JJ	JJ	_	44	amod	_	_
43	mononuclear	mononuclear	JJ	JJ	_	44	amod	_	_
44	leukocytes	leukocyte	NNS	NNS	_	31	conj	_	_
45	.	.	.	.	_	6	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	effect	effect	NN	NN	_	19	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	aldosterone	aldosterone	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	sodium	sodium	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	potassium	potassium	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	calcium	calcium	NN	NN	_	9	conj	_	_
14	concentrations	concentration	NNS	NNS	_	9	dep	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	volume	volume	NN	NN	_	9	conj	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	shown	show	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	leukocytes	leukocyte	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	19	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	aldosterone	aldosterone	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	19	punct	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	Na+	na+	NN	NN	_	19	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	K+	k+	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	Ca2+	ca2+	NN	NN	_	9	conj	_	_
14	concentrations	concentration	NNS	NNS	_	9	dep	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	volume	volume	NN	NN	_	9	conj	_	_
19	decreased	decrease	VBD	VBD	_	0	root	_	_
20	significantly	significantly	RB	RB	_	19	advmod	_	_
21	,	,	,	,	_	19	punct	_	_
22	but	but	CC	CC	_	19	cc	_	_
23	remained	remain	VBD	VBD	_	19	conj	_	_
24	constant	constant	JJ	JJ	_	23	xcomp	_	_
25	when	when	WRB	WRB	_	32	advmod	_	_
26	aldosterone	aldosterone	NN	NN	_	32	nsubjpass	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	1.4	1.4	CD	CD	_	29	nummod	_	_
29	nmol/l	nmol/l	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	added	add	VBN	VBN	_	23	advcl	_	_
33	to	to	TO	TO	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	incubation	incubation	NN	NN	_	36	compound	_	_
36	medium	medium	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	aldosterone	aldosterone	NN	NN	_	11	compound	_	_
10	antagonist	antagonist	NN	NN	_	11	compound	_	_
11	canrenone	canrenone	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	140	140	CD	CD	_	14	nummod	_	_
14	nmol/l	nmol/l	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	sodium/proton	sodium/proton	JJ	JJ	_	3	amod	_	_
3	exchanger	exchanger	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	membrane	membrane	NN	NN	_	3	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	as	as	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	primary	primary	JJ	JJ	_	14	amod	_	_
14	target	target	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	aldosterone	aldosterone	NN	NN	_	18	compound	_	_
18	action	action	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	possibly	possibly	RB	RB	_	21	advmod	_	_
21	non-genomically	non-genomically	RB	RB	_	22	advmod	_	_
22	mediated	mediate	VBN	VBN	_	18	acl	_	_
23	through	through	IN	IN	_	25	case	_	_
24	membrane	membrane	NN	NN	_	25	compound	_	_
25	receptors	receptor	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	significance	significance	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	model	model	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	underlined	underline	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	demonstration	demonstration	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	absent	absent	JJ	JJ	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	a	a	DT	DT	_	17	det	_	_
16	decreased	decrease	VBN	VBN	_	17	amod	_	_
17	number	number	NN	NN	_	13	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	mineralocorticoid	mineralocorticoid	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	the	the	DT	DT	_	23	det	_	_
23	lack	lack	NN	NN	_	11	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	electrolyte	electrolyte	NN	NN	_	26	compound	_	_
26	response	response	NN	NN	_	23	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	aldosterone	aldosterone	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	mononuclear	mononuclear	JJ	JJ	_	32	amod	_	_
32	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	patients	patient	NNS	NNS	_	32	nmod	_	_
35	with	with	IN	IN	_	36	case	_	_
36	pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	aldosteronism	aldosteronism	NN	NN	_	36	conj	_	_
39	.	.	.	.	_	8	punct	_	_

1	Additionally	additionally	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	an	a	DT	DT	_	6	det	_	_
4	abnormal	abnormal	JJ	JJ	_	6	amod	_	_
5	effector	effector	NN	NN	_	6	compound	_	_
6	mechanism	mechanism	NN	NN	_	9	nsubjpass	_	_
7	could	could	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	9	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	essential	essential	JJ	JJ	_	16	amod	_	_
16	hypertensives	hypertensive	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	significance	significance	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	extrarenal	extrarenal	JJ	JJ	_	15	amod	_	_
12	,	,	,	,	_	15	punct	_	_
13	nonepithelial	nonepithelial	JJ	JJ	_	15	amod	_	_
14	mineralocorticoid	mineralocorticoid	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	20	det	_	_
18	related	related	JJ	JJ	_	20	amod	_	_
19	effector	effector	NN	NN	_	20	compound	_	_
20	mechanism	mechanism	NN	NN	_	15	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	different	different	JJ	JJ	_	23	amod	_	_
23	disorders	disorder	NNS	NNS	_	9	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	dep	_	_
26	water	water	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	electrolyte	electrolyte	NN	NN	_	26	conj	_	_
29	balance	balance	NN	NN	_	26	dep	_	_
30	in	in	IN	IN	_	31	case	_	_
31	man	man	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	Single	single	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	assay	assay	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	nmod	_	_
8	reveals	reveal	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	threshold	threshold	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	transcription	transcription	NN	NN	_	8	nmod	_	_
13	activated	activate	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	signals	signal	NNS	NNS	_	13	nmod	_	_
16	emanating	emanate	VBG	VBG	_	15	acl	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	T-cell	t-cell	NN	NN	_	21	compound	_	_
20	antigen	antigen	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Stimulation	stimulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	through	through	IN	IN	_	8	case	_	_
6	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
7	antigen	antigen	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	1	nmod	_	_
9	leads	lead	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	appearance	appearance	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	several	several	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	19	case	_	_
19	NF-AT	nf-at	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	which	which	WDT	WDT	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	involved	involve	VBN	VBN	_	19	acl:relcl	_	_
27	in	in	IN	IN	_	28	mark	_	_
28	regulating	regulate	VBG	VBG	_	26	advcl	_	_
29	genes	gene	NNS	NNS	_	28	dobj	_	_
30	required	require	VBN	VBN	_	29	acl	_	_
31	for	for	IN	IN	_	33	case	_	_
32	immunologic	immunologic	JJ	JJ	_	33	amod	_	_
33	activation	activation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activity	activity	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	single	single	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	individual	individual	JJ	JJ	_	13	amod	_	_
12	viable	viable	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	we	we	PRP	PRP	_	17	nsubj	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	applied	apply	VBN	VBN	_	2	parataxis	_	_
18	an	a	DT	DT	_	19	det	_	_
19	assay	assay	NN	NN	_	17	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	uses	use	VBZ	VBZ	_	19	acl:relcl	_	_
22	the	the	DT	DT	_	25	det	_	_
23	fluorescence-activated	fluorescence-activated	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	sorter	sorter	NN	NN	_	21	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	quantitate	quantitate	VB	VB	_	21	advcl	_	_
28	beta-galactosidase	beta-galactosidase	NN	NN	_	27	dobj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	beta-gal	beta-gal	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	distribution	distribution	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF-AT	nf-at	NN	NN	_	9	compound	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	among	among	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	undergoing	undergo	VBG	VBG	_	12	acl	_	_
14	activation	activation	NN	NN	_	13	dobj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	using	use	VBG	VBG	_	3	advcl	_	_
17	a	a	DT	DT	_	18	det	_	_
18	construct	construct	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	28	nmod	_	_
21	three	three	CD	CD	_	23	nummod	_	_
22	tandem	tandem	JJ	JJ	_	23	amod	_	_
23	copies	copy	NNS	NNS	_	28	nsubj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	NF-AT-binding	nf-at-binding	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	23	nmod	_	_
28	directs	direct	VBZ	VBZ	_	18	acl:relcl	_	_
29	transcription	transcription	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	lacZ	lacz	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	stimulation	stimulation	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	10	case	_	_
5	cloned	clone	VBN	VBN	_	10	amod	_	_
6	stably	stably	RB	RB	_	10	advmod	_	_
7	transfected	transfect	VBN	VBN	_	10	amod	_	_
8	Jurkat	jurkat	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	nmod	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	bimodal	bimodal	JJ	JJ	_	15	amod	_	_
15	pattern	pattern	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	beta-gal	beta-gal	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	23	nmod	_	_
21	some	some	DT	DT	_	22	det	_	_
22	cells	cell	NNS	NNS	_	23	nsubj	_	_
23	express	express	VBP	VBP	_	15	acl:relcl	_	_
24	no	no	DT	DT	_	25	neg	_	_
25	beta-gal	beta-gal	NN	NN	_	23	dobj	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	others	other	NNS	NNS	_	28	nsubj	_	_
28	express	express	VBP	VBP	_	23	conj	_	_
29	high	high	JJ	JJ	_	30	amod	_	_
30	levels	level	NNS	NNS	_	28	dobj	_	_
31	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	pattern	pattern	NN	NN	_	7	nsubjpass	_	_
4	can	can	MD	MD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	accounted	account	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	11	case	_	_
9	by	by	IN	IN	_	11	case	_	_
10	cell-cycle	cell-cycle	JJ	JJ	_	11	amod	_	_
11	position	position	NN	NN	_	7	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	heritable	heritable	JJ	JJ	_	14	amod	_	_
14	variation	variation	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	7	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	14	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	9	nmod	_	_
6	beta-gal	beta-gal	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	correlated	correlate	VBN	VBN	_	2	acl:relcl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	NF-AT-binding	nf-at-binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	indicate	indicate	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	concentration	concentration	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	NF-AT	nf-at	NN	NN	_	17	nmod	_	_
20	must	must	MD	MD	_	21	aux	_	_
21	exceed	exceed	VB	VB	_	14	ccomp	_	_
22	a	a	DT	DT	_	24	det	_	_
23	critical	critical	JJ	JJ	_	24	amod	_	_
24	threshold	threshold	NN	NN	_	21	dobj	_	_
25	before	before	IN	IN	_	27	mark	_	_
26	transcription	transcription	NN	NN	_	27	nsubj	_	_
27	initiates	initiate	VBZ	VBZ	_	21	advcl	_	_
28	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	threshold	threshold	NN	NN	_	4	nsubj	_	_
3	likely	likely	RB	RB	_	4	advmod	_	_
4	reflects	reflect	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NF-AT	nf-at	NN	NN	_	8	compound	_	_
7	concentration-dependent	concentration-dependent	JJ	JJ	_	8	amod	_	_
8	assembly	assembly	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	complexes	complex	NNS	NNS	_	8	nmod	_	_
12	at	at	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	promoter	promoter	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	constructs	construct	NNS	NNS	_	12	nsubj	_	_
3	controlled	control	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	11	det	_	_
9	entire	entire	JJ	JJ	_	11	amod	_	_
10	interleukin-2	interleukin-2	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	6	conj	_	_
12	show	show	VBP	VBP	_	0	root	_	_
13	bimodal	bimodal	JJ	JJ	_	15	amod	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	patterns	pattern	NNS	NNS	_	12	dobj	_	_
16	during	during	IN	IN	_	17	case	_	_
17	induction	induction	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	suggesting	suggest	VBG	VBG	_	12	advcl	_	_
20	that	that	IN	IN	_	33	mark	_	_
21	thresholds	threshold	NNS	NNS	_	33	nsubj	_	_
22	set	set	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	concentration	concentration	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	may	may	MD	MD	_	33	aux	_	_
30	be	be	VB	VB	_	33	cop	_	_
31	a	a	DT	DT	_	33	det	_	_
32	common	common	JJ	JJ	_	33	amod	_	_
33	property	property	NN	NN	_	19	ccomp	_	_
34	of	of	IN	IN	_	36	case	_	_
35	inducible	inducible	JJ	JJ	_	36	amod	_	_
36	genes	gene	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	Type-II	type-ii	JJ	JJ	_	4	amod	_	_
2	estrogen	estrogen	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	lymphoblastoid	lymphoblastoid	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	growth-inhibitory	growth-inhibitory	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	4	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	estrogen	estrogen	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	anti-estrogen	anti-estrogen	NN	NN	_	14	conj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	bioflavonoids	bioflavonoid	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Type-II	type-ii	JJ	JJ	_	3	amod	_	_
2	estrogen-binding	estrogen-binding	JJ	JJ	_	3	amod	_	_
3	sites	site	NNS	NNS	_	10	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	type-II	type-ii	JJ	JJ	_	6	amod	_	_
6	EBS	eb	NNS	NNS	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	lymphoblastoid	lymphoblastoid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	10	nmod	_	_
17	IM-9	im-9	NN	NN	_	16	dep	_	_
18	using	use	VBG	VBG	_	10	xcomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	whole-cell	whole-cell	JJ	JJ	_	21	amod	_	_
21	assay	assay	NN	NN	_	18	dobj	_	_
22	with	with	IN	IN	_	28	case	_	_
23	(	(	-LRB-	-LRB-	_	28	punct	_	_
24	6,7-3H	6,7-3h	NN	NN	_	28	compound	_	_
25	)	)	-RRB-	-RRB-	_	28	punct	_	_
26	estradiol	estradiol	NN	NN	_	28	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	3H-E2	3h-e2	NN	NN	_	21	nmod	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	as	as	IN	IN	_	31	case	_	_
31	tracer	tracer	NN	NN	_	18	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Competition	competition	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	anti-estrogen	anti-estrogen	JJ	JJ	_	7	amod	_	_
7	tamoxifen	tamoxifen	NN	NN	_	14	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	flavonoids	flavonoid	NNS	NNS	_	11	compound	_	_
11	quercetin	quercetin	NN	NN	_	7	conj	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	rutin	rutin	NN	NN	_	7	conj	_	_
14	competed	compete	VBD	VBD	_	3	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	(3H)-E2	(3h)-e2	NN	NN	_	17	compound	_	_
17	binding	binding	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	type-II	type-ii	JJ	JJ	_	20	amod	_	_
20	EBS	eb	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Growth	growth	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	diethylstilbestrol	diethylstilbestrol	NN	NN	_	17	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DES	des	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	tamoxifen	tamoxifen	NN	NN	_	5	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TAM	tam	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	5	punct	_	_
14	quercetin	quercetin	NN	NN	_	5	conj	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	rutin	rutin	NN	NN	_	5	conj	_	_
17	exerted	exert	VBD	VBD	_	3	ccomp	_	_
18	a	a	DT	DT	_	21	det	_	_
19	reversible	reversible	JJ	JJ	_	21	amod	_	_
20	dose-dependent	dose-dependent	JJ	JJ	_	19	dep	_	_
21	inhibition	inhibition	NN	NN	_	17	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	proliferation	proliferation	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	range	range	NN	NN	_	17	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	concentrations	concentration	NNS	NNS	_	27	nmod	_	_
30	between	between	IN	IN	_	32	case	_	_
31	10	10	CD	CD	_	32	nummod	_	_
32	nM	nm	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	10	10	CD	CD	_	35	nummod	_	_
35	microM	microm	NN	NN	_	32	conj	_	_
36	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	relative	relative	JJ	JJ	_	4	amod	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	affinity	affinity	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	quercetin	quercetin	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	rutin	rutin	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	DES	des	NN	NN	_	6	conj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	TAM	TAM	NNP	NNP	_	6	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	type-II	type-ii	JJ	JJ	_	15	amod	_	_
15	EBS	eb	NNS	NNS	_	6	nmod	_	_
16	correlated	correlate	VBD	VBD	_	0	root	_	_
17	well	well	RB	RB	_	16	advmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	potency	potency	NN	NN	_	16	nmod	_	_
21	as	as	IN	IN	_	24	case	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	inhibitors	inhibitor	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Moreover	moreover	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	hesperidin	hesperidin	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	flavonoid	flavonoid	NN	NN	_	3	appos	_	_
7	which	which	WDT	WDT	_	10	nsubj	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	bind	bind	VB	VB	_	6	acl:relcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	type-II	type-ii	JJ	JJ	_	13	amod	_	_
13	EBS	eb	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	ineffective	ineffective	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	inhibiting	inhibit	VBG	VBG	_	16	advcl	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	growth	growth	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	16	punct	_	_

1	Cell-cycle	cell-cycle	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	growth-inhibitory	growth-inhibitory	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	DES	des	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	TAM	tam	NN	NN	_	9	conj	_	_
12	or	or	CC	CC	_	9	cc	_	_
13	quercetin	quercetin	NN	NN	_	9	conj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	due	due	JJ	JJ	_	3	ccomp	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	blocking	blocking	NN	NN	_	19	compound	_	_
19	effect	effect	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	G0-G1	g0-g1	JJ	JJ	_	23	amod	_	_
23	phases	phase	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	estrogen	estrogen	NN	NN	_	13	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	anti-estrogen	anti-estrogen	JJ	JJ	_	6	conj	_	_
9	concentrations	concentration	NNS	NNS	_	6	dep	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	flavonoids	flavonoid	NNS	NNS	_	6	conj	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	regulate	regulate	VB	VB	_	3	ccomp	_	_
14	IM-9	im-9	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	growth	growth	NN	NN	_	13	dobj	_	_
17	through	through	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	common	common	JJ	JJ	_	20	amod	_	_
20	mechanism	mechanism	NN	NN	_	13	nmod	_	_
21	involving	involve	VBG	VBG	_	20	acl	_	_
22	a	a	DT	DT	_	24	det	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	interaction	interaction	NN	NN	_	21	dobj	_	_
25	with	with	IN	IN	_	27	case	_	_
26	type-II	type-ii	JJ	JJ	_	27	amod	_	_
27	EBS	eb	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	distinct	distinct	JJ	JJ	_	5	amod	_	_
3	signal	signal	NN	NN	_	5	compound	_	_
4	transmission	transmission	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	10	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	complexes	complex	NNS	NNS	_	10	nmod	_	_
13	formed	form	VBN	VBN	_	12	acl	_	_
14	between	between	IN	IN	_	16	case	_	_
15	an	a	DT	DT	_	16	det	_	_
16	immunophilin	immunophilin	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	either	either	CC	CC	_	19	cc:preconj	_	_
19	FK506	fk506	NN	NN	_	16	conj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	rapamycin	rapamycin	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	Proliferation	proliferation	NN	NN	_	9	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	immunologic	immunologic	JJ	JJ	_	4	amod	_	_
4	function	function	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	initiated	initiate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	signals	signal	NNS	NNS	_	9	nmod	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	antigen	antigen	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	inhibited	inhibit	VBN	VBN	_	11	acl:relcl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	immunosuppressant	immunosuppressant	JJ	JJ	_	22	amod	_	_
22	FK506	fk506	NN	NN	_	18	nmod	_	_
23	but	but	CC	CC	_	22	cc	_	_
24	not	not	RB	RB	_	28	neg	_	_
25	by	by	IN	IN	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	structural	structural	JJ	JJ	_	28	amod	_	_
28	analog	analog	NN	NN	_	22	conj	_	_
29	,	,	,	,	_	28	punct	_	_
30	rapamycin	rapamycin	NN	NN	_	28	appos	_	_
31	.	.	.	.	_	9	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	interleukin	interleukin	NN	NN	_	12	compound	_	_
7	2	2	CD	CD	_	12	nummod	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	IL-2	il-2	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	-induced	-induced	JJ	JJ	_	12	amod	_	_
12	signals	signal	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	rapamycin	rapamycin	NN	NN	_	14	nmod	_	_
17	but	but	CC	CC	_	16	cc	_	_
18	not	not	RB	RB	_	20	neg	_	_
19	by	by	IN	IN	_	20	case	_	_
20	FK506	fk506	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	14	punct	_	_

1	Remarkably	remarkably	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	5	det	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	drugs	drug	NNS	NNS	_	6	nsubj	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	each	each	DT	DT	_	10	det	_	_
8	other	other	JJ	JJ	_	10	amod	_	_
9	's	's	POS	POS	_	10	case	_	_
10	actions	action	NNS	NNS	_	6	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	raising	raise	VBG	VBG	_	6	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	possibility	possibility	NN	NN	_	12	dobj	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	both	both	DT	DT	_	17	nsubj	_	_
17	act	act	VBP	VBP	_	14	ccomp	_	_
18	by	by	IN	IN	_	19	case	_	_
19	means	means	NNS	NNS	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	common	common	JJ	JJ	_	23	amod	_	_
23	immunophilin	immunophilin	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	27	punct	_	_
25	immunosuppressant	immunosuppressant	JJ	JJ	_	27	amod	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	23	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	22	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	dissociation	dissociation	NN	NN	_	6	compound	_	_
6	constant	constant	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	rapamycin	rapamycin	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	FK506	fk506	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	6	nmod	_	_
14	FKBP	fkbp	NN	NN	_	13	dep	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	Kd	kd	NN	NN	_	6	dep	_	_
17	=	=	JJ	JJ	_	16	amod	_	_
18	0.2	0.2	CD	CD	_	19	nummod	_	_
19	nM	nm	NN	NN	_	17	dep	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	close	close	JJ	JJ	_	2	ccomp	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	dissociation	dissociation	NN	NN	_	26	compound	_	_
26	constant	constant	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	FK506	fk506	NN	NN	_	26	nmod	_	_
29	to	to	TO	TO	_	30	case	_	_
30	FKBP	fkbp	NN	NN	_	26	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	Kd	kd	NN	NN	_	26	dep	_	_
33	=	=	JJ	JJ	_	32	amod	_	_
34	0.4	0.4	CD	CD	_	35	nummod	_	_
35	nM	nm	NN	NN	_	33	dep	_	_
36	)	)	-RRB-	-RRB-	_	32	punct	_	_
37	and	and	CC	CC	_	26	cc	_	_
38	to	to	TO	TO	_	43	case	_	_
39	their	they	PRP$	PRP$	_	43	nmod:poss	_	_
40	effective	effective	JJ	JJ	_	42	amod	_	_
41	biologic	biologic	JJ	JJ	_	42	amod	_	_
42	inhibitory	inhibitory	JJ	JJ	_	43	amod	_	_
43	concentrations	concentration	NNS	NNS	_	26	conj	_	_
44	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	excess	excess	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	rapamycin	rapamycin	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	needed	need	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	revert	revert	VB	VB	_	8	xcomp	_	_
11	FK506-mediated	fk506-mediated	JJ	JJ	_	12	amod	_	_
12	inhibition	inhibition	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	apoptosis	apoptosis	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-AT	nf-at	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	a	a	DT	DT	_	28	det	_	_
26	T-cell-specific	t-cell-specific	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	23	appos	_	_
29	necessary	necessary	JJ	JJ	_	28	amod	_	_
30	for	for	IN	IN	_	33	case	_	_
31	IL-2	il-2	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Similarly	similarly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	excess	excess	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	FK506	fk506	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	needed	need	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	revert	revert	VB	VB	_	8	xcomp	_	_
11	rapamycin-mediated	rapamycin-mediated	JJ	JJ	_	12	amod	_	_
12	inhibition	inhibition	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IL-2-induced	il-2-induced	JJ	JJ	_	15	amod	_	_
15	proliferation	proliferation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	drug	drug	NN	NN	_	3	compound	_	_
3	concentrations	concentration	NNS	NNS	_	9	nsubjpass	_	_
4	required	require	VBN	VBN	_	3	acl	_	_
5	for	for	IN	IN	_	6	case	_	_
6	antagonism	antagonism	NN	NN	_	4	nmod	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	explained	explain	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	relative	relative	JJ	JJ	_	13	amod	_	_
13	affinity	affinity	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	drugs	drug	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	16	acl	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	abundance	abundance	NN	NN	_	13	conj	_	_
23	of	of	IN	IN	_	22	acl	_	_
24	,	,	,	,	_	22	punct	_	_
25	the	the	DT	DT	_	26	det	_	_
26	immunophilin	immunophilin	NN	NN	_	22	appos	_	_
27	FKBP	fkbp	NN	NN	_	26	dep	_	_
28	.	.	.	.	_	9	punct	_	_

1	FKBP	fkbp	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	catalyze	catalyze	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interconversion	interconversion	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	cis-	cis-	JJ	JJ	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	trans-rotamers	trans-rotamer	NNS	NNS	_	11	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	peptidyl-prolyl	peptidyl-prolyl	JJ	JJ	_	18	amod	_	_
17	amide	amide	NN	NN	_	18	compound	_	_
18	bond	bond	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	peptide	peptide	NN	NN	_	21	compound	_	_
21	substrates	substrate	NNS	NNS	_	18	nmod	_	_
22	;	;	:	:	_	4	punct	_	_
23	here	here	RB	RB	_	25	advmod	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	show	show	VBP	VBP	_	4	parataxis	_	_
26	that	that	IN	IN	_	35	mark	_	_
27	rapamycin	rapamycin	NN	NN	_	35	nsubj	_	_
28	,	,	,	,	_	27	punct	_	_
29	like	like	IN	IN	_	30	case	_	_
30	FK506	fk506	NN	NN	_	35	nmod	_	_
31	,	,	,	,	_	35	punct	_	_
32	is	be	VBZ	VBZ	_	35	cop	_	_
33	a	a	DT	DT	_	35	det	_	_
34	potent	potent	JJ	JJ	_	35	amod	_	_
35	inhibitor	inhibitor	NN	NN	_	25	ccomp	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	rotamase	rotamase	NN	NN	_	39	compound	_	_
39	activity	activity	NN	NN	_	35	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	FKBP	fkbp	NN	NN	_	39	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	Ki	ki	NN	NN	_	35	dep	_	_
44	=	=	JJ	JJ	_	43	amod	_	_
45	0.2	0.2	CD	CD	_	46	nummod	_	_
46	nM	nm	NN	NN	_	44	dep	_	_
47	)	)	-RRB-	-RRB-	_	43	punct	_	_
48	.	.	.	.	_	4	punct	_	_

1	Neither	neither	CC	CC	_	3	cc:preconj	_	_
2	FKBP	fkbp	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	13	nsubj	_	_
4	nor	nor	CC	CC	_	3	cc	_	_
5	inhibition	inhibition	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	rotamase	rotamase	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	FKBP	fkbp	NN	NN	_	8	nmod	_	_
11	alone	alone	RB	RB	_	3	advmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	explain	explain	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	biologic	biologic	JJ	JJ	_	18	amod	_	_
18	actions	action	NNS	NNS	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	drugs	drug	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Rather	rather	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	immunophilin	immunophilin	NN	NN	_	11	nsubj	_	_
8	bound	bind	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	10	case	_	_
10	FK506	fk506	NN	NN	_	8	nmod	_	_
11	interferes	interfere	VBZ	VBZ	_	5	ccomp	_	_
12	with	with	IN	IN	_	15	case	_	_
13	antigen	antigen	NN	NN	_	15	compound	_	_
14	receptor-induced	receptor-induced	JJ	JJ	_	15	amod	_	_
15	signals	signal	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	while	while	IN	IN	_	23	mark	_	_
18	rapamycin	rapamycin	NN	NN	_	23	nsubj	_	_
19	bound	bind	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	immunophilin	immunophilin	NN	NN	_	19	nmod	_	_
23	interferes	interfere	VBZ	VBZ	_	11	advcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	IL-2-induced	il-2-induced	JJ	JJ	_	26	amod	_	_
26	signals	signal	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Disruption	disruption	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	SCL	scl	NN	NN	_	6	compound	_	_
6	locus	locus	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	12	case	_	_
8	``	``	``	``	_	12	punct	_	_
9	illegitimate	illegitimate	JJ	JJ	_	12	amod	_	_
10	V-(D)-J	v-(d)-j	NN	NN	_	12	compound	_	_
11	recombinase	recombinase	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	fusion	fusion	NN	NN	_	4	compound	_	_
3	complementary	complementary	JJ	JJ	_	4	amod	_	_
4	DNA	dna	NN	NN	_	11	nsubj	_	_
5	in	in	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	T	t	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	line	line	NN	NN	_	10	compound	_	_
10	HSB-2	hsb-2	NN	NN	_	4	nmod	_	_
11	elucidates	elucidate	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	provocative	provocative	JJ	JJ	_	14	amod	_	_
14	mechanism	mechanism	NN	NN	_	11	dobj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	disruption	disruption	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	putative	putative	JJ	JJ	_	23	amod	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	17	nmod	_	_
24	SCL	scl	NN	NN	_	23	dep	_	_
25	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	fusion	fusion	NN	NN	_	3	compound	_	_
3	cDNA	cdna	NN	NN	_	4	nsubj	_	_
4	results	result	VBZ	VBZ	_	0	root	_	_
5	from	from	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	interstitial	interstitial	JJ	JJ	_	8	amod	_	_
8	deletion	deletion	NN	NN	_	4	nmod	_	_
9	between	between	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	previously	previously	RB	RB	_	12	advmod	_	_
12	unknown	unknown	JJ	JJ	_	13	amod	_	_
13	locus	locus	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	SIL	sil	NN	NN	_	13	appos	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	SCL	scl	NN	NN	_	19	compound	_	_
18	interrupting	interrupting	NN	NN	_	19	compound	_	_
19	locus	locus	NN	NN	_	15	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	13	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	5'	5'	JJ	JJ	_	26	amod	_	_
25	untranslated	untranslated	JJ	JJ	_	26	amod	_	_
26	region	region	NN	NN	_	13	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	SCL	scl	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	10	advmod	_	_
2	to	to	TO	TO	_	6	case	_	_
3	1	1	CD	CD	_	6	nummod	_	_
4	;	;	:	:	_	6	punct	_	_
5	14	14	CD	CD	_	6	nummod	_	_
6	translocations	translocation	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	this	this	DT	DT	_	9	det	_	_
9	deletion	deletion	NN	NN	_	10	nsubj	_	_
10	disrupts	disrupt	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	15	det	_	_
12	SCL	scl	NN	NN	_	15	compound	_	_
13	5'	5'	JJ	JJ	_	15	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	10	dobj	_	_
16	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	event	event	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	probably	probably	RB	RB	_	5	advmod	_	_
5	mediated	mediate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	V-(D)-J	v-(d)-j	NN	NN	_	9	compound	_	_
8	recombinase	recombinase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	although	although	IN	IN	_	16	mark	_	_
12	neither	neither	DT	DT	_	13	det	_	_
13	locus	locus	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	an	a	DT	DT	_	16	det	_	_
16	immunoglobulin	immunoglobulin	NN	NN	_	5	advcl	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	a	a	DT	DT	_	21	det	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	12	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	CEM	cem	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	RPMI	rpmi	NN	NN	_	7	conj	_	_
10	8402	8402	CD	CD	_	9	nummod	_	_
11	,	,	,	,	_	5	punct	_	_
12	have	have	VBP	VBP	_	0	root	_	_
13	essentially	essentially	RB	RB	_	14	advmod	_	_
14	identical	identical	JJ	JJ	_	15	amod	_	_
15	deletions	deletion	NNS	NNS	_	12	dobj	_	_
16	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	growth-affecting	growth-affecting	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	12	nsubj	_	_
8	other	other	JJ	JJ	_	7	cc	_	_
9	than	than	IN	IN	_	8	dep	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	receptors	receptor	NNS	NNS	_	7	conj	_	_
12	risk	risk	VBP	VBP	_	0	root	_	_
13	rearrangements	rearrangement	NNS	NNS	_	12	dobj	_	_
14	.	.	.	.	_	12	punct	_	_

1	Differences	difference	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	enhancers	enhancer	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HIV-1	hiv-1	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	HIV-2	hiv-2	NN	NN	_	6	conj	_	_
9	.	.	.	.	_	1	punct	_	_

1	Response	response	NN	NN	_	0	root	_	_
2	to	to	TO	TO	_	6	case	_	_
3	T	t	NN	NN	_	6	compound	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	signals	signal	NNS	NNS	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	results	result	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	thought	think	VBN	VBN	_	4	conj	_	_
14	to	to	TO	TO	_	17	mark	_	_
15	be	be	VB	VB	_	17	cop	_	_
16	one	one	CD	CD	_	17	nummod	_	_
17	mechanism	mechanism	NN	NN	_	13	xcomp	_	_
18	leading	lead	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	conversion	conversion	NN	NN	_	18	nmod	_	_
22	from	from	IN	IN	_	23	case	_	_
23	latent	latent	JJ	JJ	_	27	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	active	active	JJ	JJ	_	27	nmod	_	_
26	viral	viral	JJ	JJ	_	27	amod	_	_
27	infection	infection	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	HIV-1	hiv-1	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	sequences	sequence	NNS	NNS	_	13	nsubjpass	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	respond	respond	VBP	VBP	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	events	event	NNS	NNS	_	7	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	long	long	JJ	JJ	_	18	amod	_	_
17	terminal	terminal	JJ	JJ	_	18	amod	_	_
18	repeat	repeat	NN	NN	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	LTR	ltr	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	comprise	comprise	VBP	VBP	_	13	conj	_	_
24	the	the	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	enhancer	enhancer	NN	NN	_	23	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	contains	contain	VBZ	VBZ	_	26	acl:relcl	_	_
30	two	two	CD	CD	_	33	nummod	_	_
31	conserved	conserve	VBN	VBN	_	33	amod	_	_
32	binding	bind	VBG	VBG	_	33	amod	_	_
33	sites	site	NNS	NNS	_	29	dobj	_	_
34	for	for	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
37	factor	factor	NN	NN	_	39	compound	_	_
38	kappa	kappa	NN	NN	_	39	compound	_	_
39	B	b	NN	NN	_	33	nmod	_	_
40	(	(	-LRB-	-LRB-	_	43	punct	_	_
41	NF	nf	NN	NN	_	43	compound	_	_
42	kappa	kappa	NN	NN	_	43	compound	_	_
43	B	b	NN	NN	_	39	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	corresponding	corresponding	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	12	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	second	second	JJ	JJ	_	8	amod	_	_
7	AIDS	aids	NN	NN	_	8	compound	_	_
8	retrovirus	retrovirus	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	HIV-2	hiv-2	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	contains	contain	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	12	dobj	_	_
14	conserved	conserve	VBN	VBN	_	13	amod	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	a	a	DT	DT	_	17	det	_	_
17	divergent	divergent	JJ	JJ	_	13	conj	_	_
18	NF	nf	NN	NN	_	22	compound	_	_
19	kappa	kappa	NN	NN	_	22	compound	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	17	dep	_	_
23	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	LTR	ltr	NN	NN	_	7	nsubj	_	_
7	responds	respond	VBZ	VBZ	_	2	ccomp	_	_
8	better	better	JJR	JJR	_	7	advmod	_	_
9	than	than	IN	IN	_	12	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	HIV-2	hiv-2	NN	NN	_	12	compound	_	_
12	LTR	ltr	NN	NN	_	8	advcl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	activation	activation	NN	NN	_	17	compound	_	_
17	signals	signal	NNS	NNS	_	7	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	qualitative	qualitative	JJ	JJ	_	3	amod	_	_
3	differences	difference	NNS	NNS	_	12	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	response	response	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	reproduced	reproduce	VBN	VBN	_	0	root	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	only	only	RB	RB	_	21	cc:preconj	_	_
15	when	when	WRB	WRB	_	21	advmod	_	_
16	HIV-1	hiv-1	NN	NN	_	21	nsubjpass	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	HIV-2	hiv-2	NN	NN	_	16	conj	_	_
19	enhancers	enhancer	NNS	NNS	_	16	dep	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	placed	place	VBN	VBN	_	12	advcl	_	_
22	upstream	upstream	RB	RB	_	21	advmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	heterologous	heterologous	JJ	JJ	_	26	amod	_	_
26	promoter	promoter	NN	NN	_	22	nmod	_	_
27	but	but	CC	CC	_	21	cc	_	_
28	also	also	RB	RB	_	33	advmod	_	_
29	when	when	WRB	WRB	_	33	advmod	_	_
30	these	these	DT	DT	_	31	det	_	_
31	enhancers	enhancer	NNS	NNS	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	switched	switch	VBN	VBN	_	21	conj	_	_
34	between	between	IN	IN	_	37	case	_	_
35	their	they	PRP$	PRP$	_	37	nmod:poss	_	_
36	respective	respective	JJ	JJ	_	37	amod	_	_
37	LTR	ltr	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	NF	nf	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	nsubj	_	_
10	binds	bind	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	both	both	CC	CC	_	14	dep	_	_
13	conserved	conserve	VBN	VBN	_	14	dep	_	_
14	sites	site	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	enhancer	enhancer	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	only	only	RB	RB	_	26	advmod	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	single	single	JJ	JJ	_	26	amod	_	_
25	conserved	conserve	VBN	VBN	_	26	amod	_	_
26	site	site	NN	NN	_	14	conj	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	HIV-2	hiv-2	NN	NN	_	31	compound	_	_
30	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
31	enhancer	enhancer	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Instead	instead	RB	RB	_	11	advmod	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF	nf	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	activator	activator	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	11	nsubj	_	_
10	3	3	CD	CD	_	9	nummod	_	_
11	binds	bind	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	divergent	divergent	JJ	JJ	_	15	amod	_	_
15	site	site	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	HIV-2	hiv-2	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	HIV-1	hiv-1	NN	NN	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	HIV-2	hiv-2	NN	NN	_	4	conj	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	differentially	differentially	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	activation	activation	NN	NN	_	14	compound	_	_
14	signals	signal	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	this	this	DT	DT	_	18	det	_	_
18	difference	difference	NN	NN	_	20	nsubj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	account	account	VB	VB	_	9	conj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	longer	longer	JJR	JJR	_	24	amod	_	_
24	period	period	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	viral	viral	JJ	JJ	_	27	amod	_	_
27	latency	latency	NN	NN	_	24	nmod	_	_
28	observed	observe	VBN	VBN	_	24	acl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	HIV-2	hiv-2	NN	NN	_	28	nmod	_	_
31	than	than	IN	IN	_	34	case	_	_
32	with	with	IN	IN	_	33	case	_	_
33	HIV-1	hiv-1	NN	NN	_	34	dep	_	_
34	infection	infection	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-KB	nf-kb	NN	NN	_	1	nmod	_	_
4	during	during	IN	IN	_	6	case	_	_
5	monocyte	monocyte	NN	NN	_	6	compound	_	_
6	differentiation	differentiation	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	HIV	hiv	NN	NN	_	11	compound	_	_
9	type	type	NN	NN	_	11	compound	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	infection	infection	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	production	production	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	12	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HIV-1	hiv-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	progeny	progeny	NN	NN	_	2	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	followed	follow	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	U937	u937	NN	NN	_	20	compound	_	_
18	promonocytic	promonocytic	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	14	nmod	_	_
21	after	after	IN	IN	_	22	case	_	_
22	stimulation	stimulation	NN	NN	_	14	nmod	_	_
23	either	either	CC	CC	_	26	dep	_	_
24	with	with	IN	IN	_	26	case	_	_
25	retinoic	retinoic	JJ	JJ	_	26	amod	_	_
26	acid	acid	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	PMA	pma	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	14	punct	_	_
30	and	and	CC	CC	_	14	cc	_	_
31	in	in	IN	IN	_	34	case	_	_
32	purified	purify	VBN	VBN	_	34	amod	_	_
33	human	human	JJ	JJ	_	34	amod	_	_
34	monocytes	monocyte	NNS	NNS	_	14	conj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	macrophages	macrophage	NNS	NNS	_	34	conj	_	_
37	.	.	.	.	_	14	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Southwestern	southwestern	NN	NN	_	8	compound	_	_
7	blotting	blotting	NN	NN	_	8	compound	_	_
8	experiments	experiment	NNS	NNS	_	4	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	detect	detect	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	binding	binding	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	cellular	cellular	JJ	JJ	_	19	amod	_	_
17	transactivation	transactivation	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	NF-KB	nf-kb	NN	NN	_	14	nmod	_	_
20	to	to	TO	TO	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	double	double	JJ	JJ	_	25	amod	_	_
23	repeat-KB	repeat-kb	JJ	JJ	_	25	amod	_	_
24	enhancer	enhancer	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	14	nmod	_	_
26	located	located	JJ	JJ	_	25	amod	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	long	long	JJ	JJ	_	31	amod	_	_
30	terminal	terminal	JJ	JJ	_	31	amod	_	_
31	repeat	repeat	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	PMA	pma	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	and	and	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
7	acid	acid	NN	NN	_	8	compound	_	_
8	treatment	treatment	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	acts	act	VBZ	VBZ	_	0	root	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	13	advcl	_	_
16	NF-KB	nf-kb	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nuclei	nucleus	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	extracts	extract	NNS	NNS	_	12	nmod	_	_
4	from	from	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	macrophages	macrophage	NNS	NNS	_	5	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	induction	induction	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-KB	nf-kb	NN	NN	_	9	nmod	_	_
12	occurred	occur	VBD	VBD	_	0	root	_	_
13	only	only	RB	RB	_	19	advmod	_	_
14	if	if	IN	IN	_	19	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	19	nsubjpass	_	_
17	were	be	VBD	VBD	_	19	auxpass	_	_
18	previously	previously	RB	RB	_	19	advmod	_	_
19	infected	infect	VBN	VBN	_	12	advcl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	HIV-1	hiv-1	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	U937	u937	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	infected	infect	VBN	VBN	_	15	advcl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	HIV-1	hiv-1	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	15	punct	_	_
9	no	no	DT	DT	_	10	neg	_	_
10	induction	induction	NN	NN	_	15	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-KB	nf-kb	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	10	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	detected	detect	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	whereas	whereas	IN	IN	_	15	dep	_	_
18	high	high	JJ	JJ	_	19	amod	_	_
19	level	level	NN	NN	_	24	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	progeny	progeny	NN	NN	_	22	compound	_	_
22	virions	virion	NNS	NNS	_	19	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	produced	produce	VBN	VBN	_	15	parataxis	_	_
25	,	,	,	,	_	24	punct	_	_
26	suggesting	suggest	VBG	VBG	_	24	xcomp	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	this	this	DT	DT	_	29	det	_	_
29	factor	factor	NN	NN	_	32	nsubjpass	_	_
30	was	be	VBD	VBD	_	32	auxpass	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	required	require	VBN	VBN	_	26	ccomp	_	_
33	for	for	IN	IN	_	35	case	_	_
34	viral	viral	JJ	JJ	_	35	amod	_	_
35	replication	replication	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lineage	lineage	NN	NN	_	12	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	HIV-1	hiv-1	NN	NN	_	12	nsubj	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	mimic	mimic	VB	VB	_	3	ccomp	_	_
13	some	some	DT	DT	_	15	det	_	_
14	differentiation/activation	differentiation/activation	JJ	JJ	_	15	compound	_	_
15	stimuli	stimulus	NNS	NNS	_	12	dobj	_	_
16	allowing	allow	VBG	VBG	_	15	acl	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	NF-KB	nf-kb	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	CD4	cd4	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Interaction	interaction	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	fibronectin	fibronectin	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	VLA-5	vla-5	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	1	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	CD4	cd4	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	AP-1	ap-1	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	Fibronectin	fibronectin	NN	NN	_	2	nsubj	_	_
2	synergized	synergize	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	5	case	_	_
4	anti-CD3	anti-cd3	JJ	JJ	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	promote	promote	VB	VB	_	2	xcomp	_	_
8	CD4	cd4	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	proliferation	proliferation	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	serum-free	serum-free	JJ	JJ	_	15	amod	_	_
14	culture	culture	NN	NN	_	15	compound	_	_
15	system	system	NN	NN	_	7	nmod	_	_
16	whereas	whereas	IN	IN	_	20	mark	_	_
17	no	no	DT	DT	_	18	neg	_	_
18	proliferation	proliferation	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	observed	observe	VBN	VBN	_	2	advcl	_	_
21	when	when	WRB	WRB	_	25	advmod	_	_
22	CD4	cd4	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	cultured	culture	VBN	VBN	_	20	advcl	_	_
26	with	with	IN	IN	_	27	case	_	_
27	anti-CD3	anti-cd3	NN	NN	_	25	nmod	_	_
28	alone	alone	RB	RB	_	27	advmod	_	_
29	or	or	CC	CC	_	27	cc	_	_
30	fibronectin	fibronectin	NN	NN	_	27	conj	_	_
31	alone	alone	RB	RB	_	30	advmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	anti-CD29	anti-cd29	JJ	JJ	_	20	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	integrin	integrin	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	4	dep	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	)	)	-RRB-	-RRB-	_	7	punct	_	_
10	as	as	RB	RB	_	4	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	anti-VLA-5	anti-vla-5	JJ	JJ	_	4	conj	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	fibronectin	fibronectin	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	13	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	antibodies	antibody	NNS	NNS	_	4	dep	_	_
20	blocked	block	VBD	VBD	_	0	root	_	_
21	this	this	DT	DT	_	24	det	_	_
22	CD4	cd4	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	20	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	system	system	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	20	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	anti-CD3	anti-cd3	NN	NN	_	9	nsubj	_	_
3	alone	alone	RB	RB	_	2	advmod	_	_
4	or	or	CC	CC	_	2	cc	_	_
5	fibronectin	fibronectin	NN	NN	_	2	conj	_	_
6	alone	alone	RB	RB	_	5	advmod	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	induce	induce	VB	VB	_	22	advcl	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	message	message	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	CD4	cd4	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	22	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	combination	combination	NN	NN	_	22	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	anti-CD3	anti-cd3	NN	NN	_	17	nmod	_	_
20	plus	plus	CC	CC	_	19	cc	_	_
21	fibronectin	fibronectin	NN	NN	_	19	conj	_	_
22	induced	induce	VBD	VBD	_	0	root	_	_
23	IL-2	il-2	NN	NN	_	24	compound	_	_
24	message	message	NN	NN	_	22	dobj	_	_
25	by	by	IN	IN	_	27	case	_	_
26	CD4	cd4	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	analysis	analysis	NN	NN	_	16	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	13	nmod	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	message	message	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	generated	generate	VBN	VBN	_	7	acl:relcl	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	showed	show	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	a	a	DT	DT	_	22	det	_	_
19	fibronectin-VLA-5	fibronectin-vla-5	NN	NN	_	22	compound	_	_
20	fibronectin	fibronectin	NN	NN	_	22	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	interaction	interaction	NN	NN	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	contribute	contribute	VB	VB	_	16	ccomp	_	_
25	an	a	DT	DT	_	27	det	_	_
26	independent	independent	JJ	JJ	_	27	amod	_	_
27	signal	signal	NN	NN	_	24	dobj	_	_
28	distinct	distinct	JJ	JJ	_	27	amod	_	_
29	from	from	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	CD3	cd3	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	activation	activation	NN	NN	_	32	nmod	_	_
35	by	by	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	induction	induction	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	42	case	_	_
39	an	a	DT	DT	_	42	det	_	_
40	AP-1	ap-1	NN	NN	_	42	compound	_	_
41	transcriptional	transcriptional	JJ	JJ	_	42	amod	_	_
42	factor	factor	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	16	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	VLA-5	vla-5	NN	NN	_	5	compound	_	_
4	fibronectin	fibronectin	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	10	nsubj	_	_
6	on	on	IN	IN	_	8	case	_	_
7	CD4	cd4	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	play	play	VB	VB	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	complementary	complementary	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	CD3-TCR-mediated	cd3-tcr-mediated	JJ	JJ	_	17	amod	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	10	nmod	_	_
18	through	through	IN	IN	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	interaction	interaction	NN	NN	_	17	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	fibronectin	fibronectin	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	TAR	tar	NN	NN	_	3	compound	_	_
2	independent	independent	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
8	virus	virus	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	phorbol	phorbol	NN	NN	_	14	compound	_	_
11	ester	ester	NN	NN	_	14	compound	_	_
12	stimulated	stimulated	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Multiple	multiple	JJ	JJ	_	3	amod	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	17	nsubjpass	_	_
4	in	in	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
8	virus	virus	NN	NN	_	11	compound	_	_
9	long	long	JJ	JJ	_	11	amod	_	_
10	terminal	terminal	JJ	JJ	_	11	amod	_	_
11	repeat	repeat	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	LTR	ltr	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	0	root	_	_
18	for	for	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	HIV	hiv	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	Previous	previous	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	HIV	hiv	NN	NN	_	7	compound	_	_
6	LTR	ltr	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	3	nmod	_	_
8	linked	link	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	chloramphenicol	chloramphenicol	NN	NN	_	13	compound	_	_
12	acetyltransferase	acetyltransferase	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	indicated	indicate	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	30	mark	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	regions	region	NNS	NNS	_	30	nsubj	_	_
19	including	include	VBG	VBG	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	enhancer	enhancer	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	SP1	sp1	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	TATA	tata	NN	NN	_	21	conj	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	TAR	tar	NN	NN	_	21	conj	_	_
28	regions	region	NNS	NNS	_	27	dep	_	_
29	were	be	VBD	VBD	_	30	cop	_	_
30	important	important	JJ	JJ	_	14	ccomp	_	_
31	for	for	IN	IN	_	34	case	_	_
32	HIV	hiv	NN	NN	_	34	compound	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	these	these	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	2	dobj	_	_
6	further	further	RBR	RBR	_	2	advmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	mutations	mutation	NNS	NNS	_	13	nsubjpass	_	_
9	in	in	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	regions	region	NNS	NNS	_	8	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	inserted	insert	VBN	VBN	_	2	parataxis	_	_
14	into	into	IN	IN	_	17	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	5'	5'	JJ	JJ	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	3'	3'	JJ	JJ	_	17	conj	_	_
20	HIV	hiv	NN	NN	_	21	compound	_	_
21	LTRs	ltr	NNS	NNS	_	17	dep	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	infectious	infectious	JJ	JJ	_	25	amod	_	_
24	proviral	proviral	JJ	JJ	_	23	dep	_	_
25	constructs	construct	NNS	NNS	_	27	nsubjpass	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	assembled	assemble	VBN	VBN	_	13	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	constructs	construct	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	transfected	transfect	VBN	VBN	_	0	root	_	_
5	into	into	IN	IN	_	8	case	_	_
6	either	either	CC	CC	_	8	cc:preconj	_	_
7	HeLa	hela	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	U937	u937	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	the	the	DT	DT	_	18	dep	_	_
18	presence	presence	NN	NN	_	4	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	absence	absence	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	phorbol	phorbol	NN	NN	_	23	compound	_	_
23	esters	ester	NNS	NNS	_	18	nmod	_	_
24	which	which	WDT	WDT	_	28	nsubjpass	_	_
25	have	have	VBP	VBP	_	28	aux	_	_
26	previously	previously	RB	RB	_	28	advmod	_	_
27	been	be	VBN	VBN	_	28	auxpass	_	_
28	demonstrated	demonstrate	VBN	VBN	_	23	acl:relcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	activate	activate	VB	VB	_	28	xcomp	_	_
31	HIV	hiv	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	4	punct	_	_

1	Viral	viral	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	assayed	assay	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	level	level	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	p24	p24	NN	NN	_	12	compound	_	_
11	gag	gag	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	nmod	_	_
13	released	release	VBN	VBN	_	12	acl	_	_
14	from	from	IN	IN	_	15	case	_	_
15	cultures	culture	NNS	NNS	_	13	nmod	_	_
16	transfected	transfect	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	proviral	proviral	JJ	JJ	_	20	amod	_	_
20	constructs	construct	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Results	result	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	all	all	DT	DT	_	5	det	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	1	nmod	_	_
6	indicated	indicate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	22	mark	_	_
8	mutations	mutation	NNS	NNS	_	22	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	SP1	sp1	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	TATA	tata	NN	NN	_	11	appos	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	TAR	tar	NN	NN	_	11	conj	_	_
17	loop	loop	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	stem	stem	NN	NN	_	21	compound	_	_
20	secondary	secondary	JJ	JJ	_	21	amod	_	_
21	structure	structure	NN	NN	_	16	conj	_	_
22	resulted	result	VBD	VBD	_	6	ccomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	marked	marked	JJ	JJ	_	25	amod	_	_
25	decreases	decrease	NNS	NNS	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	25	nmod	_	_
29	while	while	IN	IN	_	39	mark	_	_
30	mutations	mutation	NNS	NNS	_	39	nsubj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	enhancer	enhancer	NN	NN	_	34	compound	_	_
34	motif	motif	NN	NN	_	30	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	TAR	tar	NN	NN	_	38	compound	_	_
37	primary	primary	JJ	JJ	_	38	amod	_	_
38	sequence	sequence	NN	NN	_	34	conj	_	_
39	resulted	result	VBD	VBD	_	22	advcl	_	_
40	in	in	IN	IN	_	43	case	_	_
41	only	only	RB	RB	_	42	advmod	_	_
42	slight	slight	JJ	JJ	_	43	amod	_	_
43	decreases	decrease	NNS	NNS	_	39	nmod	_	_
44	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	viruses	virus	NNS	NNS	_	28	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	mutations	mutation	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	either	either	CC	CC	_	9	cc:preconj	_	_
8	the	the	DT	DT	_	9	det	_	_
9	TAR	tar	NN	NN	_	5	nmod	_	_
10	loop	loop	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	9	dep	_	_
12	or	or	CC	CC	_	9	cc	_	_
13	stem	stem	NN	NN	_	15	compound	_	_
14	secondary	secondary	JJ	JJ	_	15	amod	_	_
15	structure	structure	NN	NN	_	9	conj	_	_
16	which	which	WDT	WDT	_	19	nsubj	_	_
17	were	be	VBD	VBD	_	19	cop	_	_
18	very	very	RB	RB	_	19	advmod	_	_
19	defective	defective	JJ	JJ	_	5	acl:relcl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	untreated	untreated	JJ	JJ	_	26	amod	_	_
25	Jurkat	jurkat	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	3	punct	_	_
28	gave	give	VBD	VBD	_	0	root	_	_
29	nearly	nearly	RB	RB	_	30	advmod	_	_
30	wild-type	wild-type	JJ	JJ	_	31	amod	_	_
31	levels	level	NNS	NNS	_	28	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	phorbol	phorbol	NN	NN	_	39	compound	_	_
37	ester-treated	ester-treated	JJ	JJ	_	39	amod	_	_
38	Jurkat	jurkat	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	34	nmod	_	_
40	but	but	CC	CC	_	39	cc	_	_
41	not	not	RB	RB	_	43	neg	_	_
42	in	in	IN	IN	_	43	case	_	_
43	phorbol	phorbol	NN	NN	_	39	conj	_	_
44	ester-treated	ester-treated	JJ	JJ	_	43	amod	_	_
45	HeLa	hela	NN	NN	_	43	dep	_	_
46	or	or	CC	CC	_	43	cc	_	_
47	U937	u937	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	43	conj	_	_
49	.	.	.	.	_	28	punct	_	_

1	High	high	JJ	JJ	_	4	amod	_	_
2	level	level	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	these	these	DT	DT	_	9	det	_	_
7	TAR	tar	NN	NN	_	9	compound	_	_
8	mutant	mutant	JJ	JJ	_	9	amod	_	_
9	constructs	construct	NNS	NNS	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	phorbol	phorbol	NN	NN	_	14	compound	_	_
12	ester-treated	ester-treated	JJ	JJ	_	14	amod	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	4	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	eliminated	eliminate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	second	second	JJ	JJ	_	20	amod	_	_
19	site	site	NN	NN	_	20	compound	_	_
20	mutations	mutation	NNS	NNS	_	16	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	enhancer	enhancer	NN	NN	_	24	compound	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	20	cc	_	_
26	by	by	IN	IN	_	27	case	_	_
27	disruption	disruption	NN	NN	_	20	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	tat	tat	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Human	human	JJ	JJ	_	7	amod	_	_
2	T-cell	t-cell	NN	NN	_	7	compound	_	_
3	leukemia	leukemia	NN	NN	_	7	compound	_	_
4	virus	virus	NN	NN	_	7	compound	_	_
5	type	type	NN	NN	_	7	compound	_	_
6	I	i	CD	CD	_	7	nummod	_	_
7	Tax	tax	NN	NN	_	8	nsubj	_	_
8	associates	associate	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	8	nmod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	negatively	negatively	RB	RB	_	13	advmod	_	_
13	regulated	regulate	VBN	VBN	_	8	conj	_	_
14	by	by	IN	IN	_	13	nmod	_	_
15	the	the	DT	DT	_	20	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
17	B2	b2	NN	NN	_	20	compound	_	_
18	p100	p100	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	product	product	NN	NN	_	8	dobj	_	_
21	:	:	:	:	_	8	punct	_	_
22	implications	implication	NNS	NNS	_	8	dep	_	_
23	for	for	IN	IN	_	25	case	_	_
24	viral	viral	JJ	JJ	_	25	amod	_	_
25	latency	latency	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	22	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	13	nsubj	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-I	htlv-i	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	the	the	DT	DT	_	13	det	_	_
12	etiologic	etiologic	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	adult	adult	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	leukemia	leukemia	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	an	a	DT	DT	_	25	det	_	_
21	aggressive	aggressive	JJ	JJ	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	often	often	RB	RB	_	24	advmod	_	_
24	fatal	fatal	JJ	JJ	_	21	conj	_	_
25	malignancy	malignancy	NN	NN	_	18	appos	_	_
26	of	of	IN	IN	_	31	case	_	_
27	activated	activate	VBN	VBN	_	31	amod	_	_
28	human	human	JJ	JJ	_	31	amod	_	_
29	CD4	cd4	NN	NN	_	31	compound	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	13	punct	_	_

1	HTLV-I	htlv-i	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	6	det	_	_
4	essential	essential	JJ	JJ	_	6	amod	_	_
5	40-kDa	40-kda	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	2	dobj	_	_
7	termed	term	VBN	VBN	_	6	acl	_	_
8	Tax	tax	NN	NN	_	7	xcomp	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	only	only	RB	RB	_	12	cc:preconj	_	_
12	transactivates	transactivate	VBZ	VBZ	_	6	acl:relcl	_	_
13	the	the	DT	DT	_	16	det	_	_
14	long	long	JJ	JJ	_	16	amod	_	_
15	terminal	terminal	JJ	JJ	_	16	amod	_	_
16	repeat	repeat	NN	NN	_	12	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	retrovirus	retrovirus	NN	NN	_	16	nmod	_	_
20	but	but	CC	CC	_	12	cc	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	induces	induce	VBZ	VBZ	_	12	conj	_	_
23	an	a	DT	DT	_	24	det	_	_
24	array	array	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Tax-mediated	tax-mediated	JJ	JJ	_	2	amod	_	_
2	transformation	transformation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	likely	likely	RB	RB	_	7	advmod	_	_
7	involves	involve	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	deregulated	deregulate	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	various	various	JJ	JJ	_	14	amod	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	normally	normally	RB	RB	_	17	advmod	_	_
17	regulate	regulate	VBP	VBP	_	14	acl:relcl	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	growth	growth	NN	NN	_	17	dobj	_	_
20	produced	produce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	altered	altered	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	various	various	JJ	JJ	_	29	amod	_	_
26	endogenous	endogenous	JJ	JJ	_	29	amod	_	_
27	host	host	NN	NN	_	29	compound	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	Tax	tax	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	modulating	modulate	VBG	VBG	_	6	advcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	activity	activity	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	various	various	JJ	JJ	_	17	amod	_	_
15	host	host	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	including	include	VBG	VBG	_	20	case	_	_
20	members	member	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B/Rel	b/rel	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	CREB/ATF	creb/atf	NN	NN	_	24	conj	_	_
27	families	family	NNS	NNS	_	20	nmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	as	as	RB	RB	_	20	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	the	the	DT	DT	_	34	det	_	_
33	cellular	cellular	JJ	JJ	_	34	amod	_	_
34	factors	factor	NNS	NNS	_	20	conj	_	_
35	HEB-1	heb-1	NN	NN	_	34	dep	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	p67SRF	p67srf	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	6	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	additional	additional	JJ	JJ	_	4	amod	_	_
3	distinguishing	distinguishing	JJ	JJ	_	4	amod	_	_
4	characteristic	characteristic	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	HTLV-I	htlv-i	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	the	the	DT	DT	_	11	det	_	_
10	profound	profound	JJ	JJ	_	11	amod	_	_
11	state	state	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	latency	latency	NN	NN	_	11	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	present	present	JJ	JJ	_	14	acl:relcl	_	_
18	in	in	IN	IN	_	23	case	_	_
19	circulating	circulate	VBG	VBG	_	23	amod	_	_
20	primary	primary	JJ	JJ	_	23	amod	_	_
21	leukemic	leukemic	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	HTLV-I	htlv-i	NN	NN	_	9	compound	_	_
9	Tax	tax	NN	NN	_	12	nsubj	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	physically	physically	RB	RB	_	12	advmod	_	_
12	associate	associate	VB	VB	_	6	ccomp	_	_
13	with	with	IN	IN	_	14	case	_	_
14	p100	p100	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	product	product	NN	NN	_	14	appos	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	Rel-related	rel-related	JJ	JJ	_	23	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B2	b2	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	both	both	CC	CC	_	28	cc:preconj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	transfected	transfect	VBN	VBN	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	12	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	in	in	IN	IN	_	34	case	_	_
31	HTLV-I-infected	htlv-i-infected	JJ	JJ	_	34	amod	_	_
32	leukemic	leukemic	JJ	JJ	_	34	amod	_	_
33	T-cell	t-cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	28	conj	_	_
35	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	physical	physical	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	p100	p100	NN	NN	_	5	nmod	_	_
10	leads	lead	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	inhibition	inhibition	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	Tax-induced	tax-induced	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	28	case	_	_
18	the	the	DT	DT	_	28	det	_	_
19	HTLV-I	htlv-i	NN	NN	_	28	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	immunodeficiency	immunodeficiency	NN	NN	_	24	compound	_	_
23	virus	virus	NN	NN	_	24	compound	_	_
24	type	type	NN	NN	_	19	conj	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	long	long	JJ	JJ	_	28	amod	_	_
27	terminal	terminal	JJ	JJ	_	28	amod	_	_
28	repeats	repeat	NNS	NNS	_	16	nmod	_	_
29	,	,	,	,	_	10	punct	_	_
30	reflecting	reflect	VBG	VBG	_	10	xcomp	_	_
31	p100-mediated	p100-mediated	JJ	JJ	_	33	amod	_	_
32	cytoplasmic	cytoplasmic	JJ	JJ	_	33	amod	_	_
33	sequestration	sequestration	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	40	case	_	_
35	the	the	DT	DT	_	40	det	_	_
36	normally	normally	RB	RB	_	38	advmod	_	_
37	nuclearly	nuclearly	RB	RB	_	38	advmod	_	_
38	expressed	express	VBN	VBN	_	40	amod	_	_
39	Tax	tax	NN	NN	_	40	compound	_	_
40	protein	protein	NN	NN	_	33	nmod	_	_
41	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	19	nmod	_	_
3	,	,	,	,	_	19	punct	_	_
4	a	a	DT	DT	_	5	det	_	_
5	mutant	mutant	NN	NN	_	19	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	selectively	selectively	RB	RB	_	10	advmod	_	_
10	fails	fail	VBZ	VBZ	_	5	acl:relcl	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	activate	activate	VB	VB	_	10	xcomp	_	_
13	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	dobj	_	_
17	does	do	VBZ	VBZ	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	associate	associate	VB	VB	_	0	root	_	_
20	with	with	IN	IN	_	21	case	_	_
21	p100	p100	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	19	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	actions	action	NNS	NNS	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cyclosporin	cyclosporin	NN	NN	_	5	compound	_	_
5	A	a	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	FK506	fk506	NN	NN	_	5	conj	_	_
8	suggest	suggest	VBP	VBP	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	novel	novel	JJ	JJ	_	11	amod	_	_
11	step	step	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	FK506	fk506	NN	NN	_	2	conj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	immunosuppressive	immunosuppressive	JJ	JJ	_	7	amod	_	_
7	compounds	compound	NNS	NNS	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	have	have	VBP	VBP	_	7	acl:relcl	_	_
10	similar	similar	JJ	JJ	_	12	amod	_	_
11	inhibitory	inhibitory	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	9	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	lymphokines	lymphokine	NNS	NNS	_	15	nmod	_	_
19	produced	produce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
3	similar	similar	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	7	nmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	drugs	drug	NNS	NNS	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	two	two	CD	CD	_	12	nummod	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	cytosolic	cytosolic	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	cyclophilin	cyclophilin	NN	NN	_	12	appos	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	FKBP	fkbp	NN	NN	_	14	conj	_	_
17	respectively	respectively	RB	RB	_	7	advmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	raises	raise	VBZ	VBZ	_	7	dep	_	_
21	the	the	DT	DT	_	22	det	_	_
22	possibility	possibility	NN	NN	_	20	dobj	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	they	they	PRP	PRP	_	25	nsubj	_	_
25	have	have	VBP	VBP	_	22	ccomp	_	_
26	different	different	JJ	JJ	_	27	amod	_	_
27	modes	mode	NNS	NNS	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	action	action	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	constructs	construct	NNS	NNS	_	1	dobj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	16	nmod	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	16	nsubjpass	_	_
7	controlled	control	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	7	nmod	_	_
13	could	could	MD	MD	_	16	aux	_	_
14	be	be	VB	VB	_	16	auxpass	_	_
15	readily	readily	RB	RB	_	16	advmod	_	_
16	measured	measure	VBN	VBN	_	2	acl:relcl	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	found	find	VBD	VBD	_	1	parataxis	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	cyclosporin	cyclosporin	NN	NN	_	22	compound	_	_
22	A	a	NN	NN	_	26	nsubj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	FK506	fk506	NN	NN	_	22	conj	_	_
25	completely	completely	RB	RB	_	26	advmod	_	_
26	inhibited	inhibit	VBD	VBD	_	18	ccomp	_	_
27	transcription	transcription	NN	NN	_	26	dobj	_	_
28	activated	activate	VBN	VBN	_	27	acl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	NF-AT	nf-at	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	NFIL2	nfil2	NN	NN	_	33	compound	_	_
33	A	a	NN	NN	_	30	appos	_	_
34	,	,	,	,	_	30	punct	_	_
35	NFIL2	nfil2	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	30	appos	_	_
37	and	and	CC	CC	_	26	cc	_	_
38	partially	partially	RB	RB	_	39	advmod	_	_
39	inhibited	inhibit	VBD	VBD	_	26	conj	_	_
40	transcription	transcription	NN	NN	_	39	dobj	_	_
41	activated	activate	VBN	VBN	_	40	acl	_	_
42	by	by	IN	IN	_	45	case	_	_
43	NF	nf	NN	NN	_	45	compound	_	_
44	kappa	kappa	NN	NN	_	45	compound	_	_
45	B	b	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	1	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	FK506	fk506	NN	NN	_	2	conj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	only	only	RB	RB	_	8	advmod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	dependent	dependent	JJ	JJ	_	8	acl:relcl	_	_
12	on	on	IN	IN	_	14	case	_	_
13	Ca2+	ca2+	NN	NN	_	14	compound	_	_
14	mobilization	mobilization	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	cyclosporin	cyclosporin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	FK506	fk506	NN	NN	_	4	conj	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	inhibit	inhibit	VB	VB	_	0	root	_	_
10	Ca2+	ca2+	NN	NN	_	13	compound	_	_
11	mobilization	mobilization	NN	NN	_	13	compound	_	_
12	dependent	dependent	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	c-fos	c-fos	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	13	nmod	_	_
17	indicating	indicate	VBG	VBG	_	9	xcomp	_	_
18	that	that	IN	IN	_	29	mark	_	_
19	only	only	RB	RB	_	21	advmod	_	_
20	a	a	DT	DT	_	21	det	_	_
21	subset	subset	NN	NN	_	29	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	signalling	signalling	NN	NN	_	24	compound	_	_
24	pathways	pathway	NNS	NNS	_	21	nmod	_	_
25	regulated	regulate	VBN	VBN	_	21	acl	_	_
26	by	by	IN	IN	_	27	case	_	_
27	Ca2+	ca2+	NN	NN	_	25	nmod	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	sensitive	sensitive	JJ	JJ	_	17	ccomp	_	_
30	to	to	TO	TO	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	drugs	drug	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	observe	observe	VB	VB	_	0	root	_	_
7	any	any	DT	DT	_	9	det	_	_
8	qualitative	qualitative	JJ	JJ	_	9	amod	_	_
9	differences	difference	NNS	NNS	_	6	dobj	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	effect	effect	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	FK506	fk506	NN	NN	_	15	conj	_	_
18	on	on	IN	IN	_	22	case	_	_
19	six	six	CD	CD	_	22	nummod	_	_
20	different	different	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	12	nmod	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	suggests	suggest	VBZ	VBZ	_	6	ccomp	_	_
25	that	that	IN	IN	_	29	mark	_	_
26	these	these	DT	DT	_	27	det	_	_
27	drugs	drug	NNS	NNS	_	29	nsubj	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	interfere	interfere	VB	VB	_	24	ccomp	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	activity	activity	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	38	case	_	_
34	a	a	DT	DT	_	38	det	_	_
35	novel	novel	JJ	JJ	_	38	amod	_	_
36	Ca2+	ca2+	NN	NN	_	38	compound	_	_
37	dependent	dependent	JJ	JJ	_	38	amod	_	_
38	step	step	NN	NN	_	32	nmod	_	_
39	that	that	WDT	WDT	_	40	nsubj	_	_
40	regulates	regulate	VBZ	VBZ	_	38	acl:relcl	_	_
41	several	several	JJ	JJ	_	43	amod	_	_
42	transcription	transcription	NN	NN	_	43	compound	_	_
43	factors	factor	NNS	NNS	_	40	dobj	_	_
44	.	.	.	.	_	6	punct	_	_

1	Lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
2	specific	specific	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	adenovirus	adenovirus	NN	NN	_	11	compound	_	_
8	early	early	JJ	JJ	_	11	amod	_	_
9	region	region	NN	NN	_	11	compound	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	promoter	promoter	NN	NN	_	4	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	18	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	motifs	motif	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	primary	primary	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	infection	infection	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	adenoviruses	adenovirus	NNS	NNS	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	analysis	analysis	NN	NN	_	23	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	viral	viral	JJ	JJ	_	8	amod	_	_
7	control	control	NN	NN	_	8	compound	_	_
8	elements	element	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	8	conj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	regulate	regulate	VBP	VBP	_	8	acl:relcl	_	_
15	adenoviral	adenoviral	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
20	has	have	VBZ	VBZ	_	23	aux	_	_
21	not	not	RB	RB	_	23	neg	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	reported	report	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	adenovirus	adenovirus	NN	NN	_	10	compound	_	_
3	early	early	JJ	JJ	_	10	amod	_	_
4	region	region	NN	NN	_	10	compound	_	_
5	3	3	CD	CD	_	10	nummod	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	ES	es	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	products	product	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	maintenance	maintenance	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	persistence	persistence	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	20	mark	_	_
20	complexing	complex	VBG	VBG	_	12	advcl	_	_
21	with	with	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	class	class	NN	NN	_	26	compound	_	_
24	I	i	CD	CD	_	26	nummod	_	_
25	MHC	mhc	NN	NN	_	26	compound	_	_
26	antigens	antigen	NNS	NNS	_	20	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	thus	thus	RB	RB	_	29	advmod	_	_
29	preventing	prevent	VBG	VBG	_	20	dep	_	_
30	their	they	PRP$	PRP$	_	33	nmod:poss	_	_
31	cell	cell	NN	NN	_	33	compound	_	_
32	surface	surface	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	29	dobj	_	_
34	with	with	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	resultant	resultant	JJ	JJ	_	37	amod	_	_
37	decrease	decrease	NN	NN	_	29	nmod	_	_
38	in	in	IN	IN	_	41	case	_	_
39	host	host	NN	NN	_	41	compound	_	_
40	immunologic	immunologic	JJ	JJ	_	41	amod	_	_
41	destruction	destruction	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	different	different	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	2	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	E3	e3	NN	NN	_	11	compound	_	_
11	regulation	regulation	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	compared	compare	VBN	VBN	_	8	advcl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	HeLa	hela	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	35	nsubjpass	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	transfection	transfection	NN	NN	_	25	compound	_	_
25	analysis	analysis	NN	NN	_	22	conj	_	_
26	with	with	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	E3	e3	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	22	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	both	both	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	types	type	NNS	NNS	_	29	nmod	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	performed	perform	VBN	VBN	_	2	parataxis	_	_
36	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	detected	detect	VBD	VBD	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	domains	domain	NNS	NNS	_	3	dobj	_	_
7	referred	refer	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	7	nmod	_	_
9	as	as	RB	RB	_	10	advmod	_	_
10	L1	l1	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	L2	l2	NN	NN	_	10	conj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	variety	variety	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	lymphoid	lymphoid	JJ	JJ	_	15	nmod	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	17	cc	_	_
20	HeLa	hela	NN	NN	_	17	conj	_	_
21	extracts	extract	NNS	NNS	_	17	dep	_	_
22	.	.	.	.	_	3	punct	_	_

1	Each	each	DT	DT	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	domains	domain	NNS	NNS	_	1	nmod	_	_
5	possessed	possess	VBD	VBD	_	0	root	_	_
6	strong	strong	JJ	JJ	_	7	amod	_	_
7	homology	homology	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	case	_	_
9	motifs	motif	NNS	NNS	_	7	nmod	_	_
10	previously	previously	RB	RB	_	7	advmod	_	_
11	found	find	VBN	VBN	_	7	acl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	bind	bind	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	18	det	_	_
15	cellular	cellular	JJ	JJ	_	18	amod	_	_
16	factor	factor	NN	NN	_	18	compound	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	13	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	Transfections	transfection	NNS	NNS	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	E3	e3	NN	NN	_	4	compound	_	_
4	constructs	construct	NNS	NNS	_	1	nmod	_	_
5	linked	link	VBN	VBN	_	4	acl	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	chloramphenicol	chloramphenicol	NN	NN	_	10	compound	_	_
9	acetyltransferase	acetyltransferase	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	23	mark	_	_
13	mutagenesis	mutagenesis	NN	NN	_	23	nsubj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	distal	distal	JJ	JJ	_	19	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	motif	motif	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	L2	l2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	had	have	VBD	VBD	_	11	ccomp	_	_
24	minimal	minimal	JJ	JJ	_	25	amod	_	_
25	effects	effect	NNS	NNS	_	23	dobj	_	_
26	on	on	IN	IN	_	28	case	_	_
27	promoter	promoter	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	23	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	HeLa	hela	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	23	punct	_	_
33	but	but	CC	CC	_	23	cc	_	_
34	resulted	result	VBD	VBD	_	23	conj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	dramatic	dramatic	JJ	JJ	_	37	amod	_	_
37	decreases	decrease	NNS	NNS	_	34	nmod	_	_
38	in	in	IN	IN	_	39	case	_	_
39	expression	expression	NN	NN	_	37	nmod	_	_
40	by	by	IN	IN	_	42	case	_	_
41	lymphoid	lymphoid	JJ	JJ	_	42	amod	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	mutagenesis	mutagenesis	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	proximal	proximal	JJ	JJ	_	9	amod	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	L1	l1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	minimal	minimal	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	13	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	HeLa	hela	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	conj	_	_
26	but	but	CC	CC	_	13	cc	_	_
27	resulted	result	VBD	VBD	_	13	conj	_	_
28	in	in	IN	IN	_	35	case	_	_
29	a	a	DT	DT	_	35	det	_	_
30	small	small	JJ	JJ	_	35	amod	_	_
31	,	,	,	,	_	30	punct	_	_
32	but	but	CC	CC	_	30	cc	_	_
33	reproducible	reproducible	JJ	JJ	_	30	conj	_	_
34	,	,	,	,	_	35	punct	_	_
35	increase	increase	NN	NN	_	27	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	35	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	lymphoid	lymphoid	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	when	when	WRB	WRB	_	43	advmod	_	_
43	coupled	couple	VBN	VBN	_	27	advcl	_	_
44	to	to	TO	TO	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	L2	l2	NN	NN	_	47	compound	_	_
47	mutation	mutation	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	13	punct	_	_

1	Reversing	reverse	VBG	VBG	_	13	dep	_	_
2	the	the	DT	DT	_	3	det	_	_
3	position	position	NN	NN	_	1	dobj	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	subsequent	subsequent	JJ	JJ	_	6	amod	_	_
6	mutagenesis	mutagenesis	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	L1	l1	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	L2	l2	NN	NN	_	9	conj	_	_
12	domains	domain	NNS	NNS	_	9	dep	_	_
13	indicated	indicate	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	30	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	30	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	motifs	motif	NNS	NNS	_	17	nmod	_	_
21	rather	rather	RB	RB	_	17	cc	_	_
22	than	than	IN	IN	_	21	mwe	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	position	position	NN	NN	_	17	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	E3	e3	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	24	nmod	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	critical	critical	JJ	JJ	_	13	ccomp	_	_
31	for	for	IN	IN	_	32	mark	_	_
32	regulating	regulate	VBG	VBG	_	30	advcl	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	13	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Positive	positive	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	negative	negative	JJ	JJ	_	1	conj	_	_
4	regulation	regulation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	immunoglobulin	immunoglobulin	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	novel	novel	JJ	JJ	_	14	amod	_	_
12	B-cell-specific	b-cell-specific	JJ	JJ	_	14	amod	_	_
13	enhancer	enhancer	NN	NN	_	14	compound	_	_
14	element	element	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	new	new	JJ	JJ	_	5	amod	_	_
3	B-cell-specific	b-cell-specific	JJ	JJ	_	5	amod	_	_
4	enhancer	enhancer	NN	NN	_	5	compound	_	_
5	element	element	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	3'	3'	JJ	JJ	_	8	nmod	_	_
10	of	of	IN	IN	_	9	case	_	_
11	E4	e4	NN	NN	_	9	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	octamerlike	octamerlike	JJ	JJ	_	15	amod	_	_
15	motifs	motif	NNS	NNS	_	11	conj	_	_
16	in	in	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	immunoglobulin	immunoglobulin	NN	NN	_	22	compound	_	_
20	heavy-chain	heavy-chain	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	enhancer	enhancer	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Tandem	tandem	JJ	JJ	_	2	amod	_	_
2	copies	copy	NNS	NNS	_	22	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	this	this	DT	DT	_	7	det	_	_
5	67-bp	67-bp	JJ	JJ	_	7	amod	_	_
6	MnlI-AluI	mnli-alui	NN	NN	_	7	compound	_	_
7	fragment	fragment	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	22	punct	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	fused	fuse	VBN	VBN	_	22	advcl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	chloramphenicol	chloramphenicol	JJ	JJ	_	15	amod	_	_
14	acetyltransferase	acetyltransferase	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	driven	drive	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	conalbumin	conalbumin	JJ	JJ	_	20	amod	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	22	punct	_	_
22	stimulated	stimulate	VBD	VBD	_	0	root	_	_
23	transcription	transcription	NN	NN	_	22	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	but	but	CC	CC	_	26	cc	_	_
28	not	not	RB	RB	_	32	neg	_	_
29	in	in	IN	IN	_	32	case	_	_
30	Jurkat	jurkat	NN	NN	_	32	compound	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	26	conj	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	HeLa	hela	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	conj	_	_
36	.	.	.	.	_	22	punct	_	_

1	Footprinting	footprinting	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	identical	identical	JJ	JJ	_	8	amod	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	CCGAAACTGAAAAGG	ccgaaactgaaaagg	NN	NN	_	14	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	designated	designate	VBN	VBN	_	8	acl	_	_
11	E6	e6	NN	NN	_	10	xcomp	_	_
12	,	,	,	,	_	8	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	protected	protect	VBN	VBN	_	3	ccomp	_	_
15	by	by	IN	IN	_	17	case	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	extracts	extract	NNS	NNS	_	14	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	or	or	CC	CC	_	20	cc	_	_
26	HeLa	hela	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	20	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	10	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	a	a	DT	DT	_	9	det	_	_
7	synthetic	synthetic	JJ	JJ	_	9	amod	_	_
8	E6	e6	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	5	dobj	_	_
10	detected	detect	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	B-cell-specific	b-cell-specific	JJ	JJ	_	13	amod	_	_
13	complex	complex	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	19	case	_	_
15	addition	addition	NN	NN	_	19	dep	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	ubiquitous	ubiquitous	JJ	JJ	_	19	amod	_	_
19	band	band	NN	NN	_	10	nmod	_	_
20	found	find	VBN	VBN	_	19	acl	_	_
21	also	also	RB	RB	_	24	advmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	HeLa	hela	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	agreement	agreement	NN	NN	_	5	dep	_	_
3	with	with	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	17	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	gel	gel	NN	NN	_	9	compound	_	_
8	retardation	retardation	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	17	punct	_	_
11	tandem	tandem	JJ	JJ	_	12	amod	_	_
12	copies	copy	NNS	NNS	_	17	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	E6	e6	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	12	nmod	_	_
17	stimulated	stimulate	VBD	VBD	_	0	root	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	ARH77	arh77	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Raji	raji	NN	NN	_	20	conj	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	but	but	CC	CC	_	23	cc	_	_
25	not	not	RB	RB	_	30	neg	_	_
26	in	in	IN	IN	_	30	case	_	_
27	Jurkat	jurkat	NN	NN	_	30	compound	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	HeLa	hela	NN	NN	_	27	conj	_	_
30	cells	cell	NNS	NNS	_	23	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	mutant	mutant	JJ	JJ	_	6	amod	_	_
5	E6	e6	NN	NN	_	6	compound	_	_
6	motif	motif	NN	NN	_	7	nsubj	_	_
7	lost	lose	VBD	VBD	_	0	root	_	_
8	both	both	CC	CC	_	12	case	_	_
9	in	in	FW	FW	_	12	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	in	in	FW	FW	_	17	amod	_	_
15	vivo	vivo	FW	FW	_	14	dep	_	_
16	enhancer	enhancer	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	striking	striking	JJ	JJ	_	3	amod	_	_
3	contrast	contrast	NN	NN	_	26	nmod	_	_
4	to	to	TO	TO	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	mouse	mouse	NN	NN	_	9	compound	_	_
7	Ig	ig	NN	NN	_	9	compound	_	_
8	heavy-chain	heavy-chain	JJ	JJ	_	9	amod	_	_
9	enhancer	enhancer	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	16	nmod	_	_
13	the	the	DT	DT	_	15	det	_	_
14	octamer	octamer	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	16	nsubj	_	_
16	acts	act	VBZ	VBZ	_	9	acl:relcl	_	_
17	as	as	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	B-cell-specific	b-cell-specific	JJ	JJ	_	21	amod	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	the	the	DT	DT	_	25	det	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	enhancer	enhancer	NN	NN	_	26	nsubj	_	_
26	contains	contain	VBZ	VBZ	_	0	root	_	_
27	an	a	DT	DT	_	29	det	_	_
28	octamerlike	octamerlike	JJ	JJ	_	29	amod	_	_
29	sequence	sequence	NN	NN	_	26	dobj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	one	one	CD	CD	_	33	nummod	_	_
32	base	base	NN	NN	_	33	compound	_	_
33	substitution	substitution	NN	NN	_	29	nmod	_	_
34	which	which	WDT	WDT	_	35	nsubj	_	_
35	bound	bind	VBD	VBD	_	29	acl:relcl	_	_
36	octamer-binding	octamer-binding	JJ	JJ	_	37	amod	_	_
37	proteins	protein	NNS	NNS	_	35	dobj	_	_
38	with	with	IN	IN	_	42	case	_	_
39	only	only	RB	RB	_	41	advmod	_	_
40	very	very	RB	RB	_	41	advmod	_	_
41	low	low	JJ	JJ	_	42	amod	_	_
42	affinity	affinity	NN	NN	_	37	nmod	_	_
43	and	and	CC	CC	_	35	cc	_	_
44	showed	show	VBD	VBD	_	35	conj	_	_
45	no	no	DT	DT	_	47	neg	_	_
46	enhancer	enhancer	NN	NN	_	47	compound	_	_
47	activity	activity	NN	NN	_	44	dobj	_	_
48	of	of	IN	IN	_	50	case	_	_
49	its	its	PRP$	PRP$	_	50	nmod:poss	_	_
50	own	own	JJ	JJ	_	47	nmod	_	_
51	.	.	.	.	_	26	punct	_	_

1	Interestingly	interestingly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	MnlI-AluI	mnli-alui	NN	NN	_	5	compound	_	_
5	fragment	fragment	NN	NN	_	7	nsubj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	suppress	suppress	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	basal-level	basal-level	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	conalbumin	conalbumin	JJ	JJ	_	14	amod	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	Jurkat	jurkat	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HeLa	hela	NN	NN	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	10	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	simian	simian	JJ	JJ	_	7	amod	_	_
4	virus	virus	NN	NN	_	7	compound	_	_
5	40	40	CD	CD	_	7	nummod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	MnlI-AluI	mnli-alui	NN	NN	_	13	compound	_	_
13	fragment	fragment	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HeLa	hela	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	but	but	CC	CC	_	16	cc	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	in	in	IN	IN	_	21	case	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	15	nsubj	_	_
7	identified	identify	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	study	study	NN	NN	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	15	cop	_	_
12	probably	probably	RB	RB	_	15	advmod	_	_
13	a	a	DT	DT	_	15	det	_	_
14	target	target	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	0	root	_	_
16	for	for	IN	IN	_	21	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	positive	positive	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	negative	negative	JJ	JJ	_	18	conj	_	_
21	factors	factor	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Synthesis	synthesis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	4,19-disubstituted	4,19-disubstituted	JJ	JJ	_	4	amod	_	_
4	derivatives	derivative	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	DOC	doc	NN	NN	_	4	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Radioreceptor	radioreceptor	NN	NN	_	2	compound	_	_
2	assay	assay	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	some	some	DT	DT	_	6	det	_	_
5	corticosteroid	corticosteroid	NN	NN	_	6	compound	_	_
6	derivatives	derivative	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	4,19-substituted	4,19-substituted	JJ	JJ	_	4	amod	_	_
4	steroids	steroid	NNS	NNS	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	previously	previously	RB	RB	_	8	advmod	_	_
7	synthesized	synthesize	VBN	VBN	_	8	amod	_	_
8	corticosteroids	corticosteroid	NNS	NNS	_	4	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	assayed	assay	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	affinity	affinity	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	type	type	NN	NN	_	16	compound	_	_
15	1	1	CD	CD	_	16	nummod	_	_
16	receptors	receptor	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
20	leukocytes	leukocyte	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	11	11	CD	CD	_	2	nummod	_	_
2	beta,19-epoxy-4,21-dihydroxypregn-4-ene-3,20-dione	beta,19-epoxy-4,21-dihydroxypregn-4-ene-3,20-dione	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	2	2	CD	CD	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	hydrogenated	hydrogenate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	Pd-C	pd-c	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	yield	yield	VB	VB	_	7	xcomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	mixture	mixture	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	all	all	DT	DT	_	18	det	_	_
16	four	four	CD	CD	_	18	nummod	_	_
17	dihydro	dihydro	NN	NN	_	18	compound	_	_
18	derivatives	derivative	NNS	NNS	_	13	nmod	_	_
19	5	5	CD	CD	_	18	nummod	_	_
20	,	,	,	,	_	11	punct	_	_
21	accompanied	accompany	VBN	VBN	_	11	dep	_	_
22	by	by	IN	IN	_	24	case	_	_
23	4,21-diacetoxy-11	4,21-diacetoxy-11	NN	NN	_	24	compound	_	_
24	beta,19-epoxy-3-hydroxypregnan-20-one	beta,19-epoxy-3-hydroxypregnan-20-one	NN	NN	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	6	6	CD	CD	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	21-acetoxy-11	21-acetoxy-11	NN	NN	_	30	compound	_	_
30	beta,19-epoxy-4-hydroxypregnane-3,20-dione	beta,19-epoxy-4-hydroxypregnane-3,20-dione	NN	NN	_	24	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	7	7	CD	CD	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	7	punct	_	_

1	With	with	IN	IN	_	8	mark	_	_
2	hot	hot	JJ	JJ	_	3	dep	_	_
3	acetic	acetic	JJ	JJ	_	6	amod	_	_
4	+	+	CC	CC	_	3	cc	_	_
5	p-toluenesulfonic	p-toluenesulfonic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	8	nsubj	_	_
7	5	5	CD	CD	_	6	nummod	_	_
8	underwent	undergo	VBD	VBD	_	24	advcl	_	_
9	rearrangement	rearrangement	NN	NN	_	8	dobj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	21-acetoxy-11	21-acetoxy-11	NN	NN	_	12	compound	_	_
12	beta,19-epoxypregn-5-ene-4,20-dione	beta,19-epoxypregn-5-ene-4,20-dione	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	8	8	CD	CD	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	Pd-C	pd-c	NN	NN	_	17	compound	_	_
17	hydrogenation	hydrogenation	NN	NN	_	24	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	3,21-diacetoxy-5	3,21-diacetoxy-5	NN	NN	_	20	compound	_	_
20	beta,19-cyclopregna-2,9(11)-diene-4,20-dione	beta,19-cyclopregna-2,9(11)-diene-4,20-dione	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	10	10	CD	CD	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	gave	give	VBD	VBD	_	0	root	_	_
25	3,21-diacetoxy-5	3,21-diacetoxy-5	NN	NN	_	26	compound	_	_
26	beta,19-cyclopregn-5-ene-4,20-dione	beta,19-cyclopregn-5-ene-4,20-dione	NN	NN	_	24	dobj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	11	11	CD	CD	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	9,11-dihydro	9,11-dihydro	NN	NN	_	33	compound	_	_
33	derivative	derivative	NN	NN	_	26	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	latter	latter	JJ	JJ	_	33	nmod	_	_
37	.	.	.	.	_	24	punct	_	_

1	Treatment	treatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	10	10	CD	CD	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	warm	warm	JJ	JJ	_	6	amod	_	_
6	HCl	hcl	NN	NN	_	1	nmod	_	_
7	furnished	furnished	JJ	JJ	_	0	root	_	_
8	19-chloro-4,21-dihydroxypregna-4,9(11)-diene-3,20-dione	19-chloro-4,21-dihydroxypregna-4,9(11)-diene-3,20-dione	NN	NN	_	7	dobj	_	_
9	(13)	(13)	CD	CD	_	8	nummod	_	_
10	.	.	.	.	_	7	punct	_	_

1	Pd-C	pd-c	NN	NN	_	2	compound	_	_
2	hydrogenation	hydrogenation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	diacetate	diacetate	NN	NN	_	2	nmod	_	_
6	14	14	CD	CD	_	5	nummod	_	_
7	afforded	afford	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	4,5-dihydro	4,5-dihydro	NN	NN	_	11	compound	_	_
10	derivative	derivative	NN	NN	_	11	compound	_	_
11	18,19-chloro-21-acetoxypregn-9(11)-en-20-one	18,19-chloro-21-acetoxypregn-9(11)-en-20-one	NN	NN	_	7	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	15	15	CD	CD	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	4-acetoxy	4-acetoxy	NN	NN	_	18	compound	_	_
18	derivative	derivative	NN	NN	_	11	conj	_	_
19	16	16	CD	CD	_	18	nummod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	3,4-diacetoxy	3,4-diacetoxy	NN	NN	_	23	compound	_	_
23	derivative	derivative	NN	NN	_	11	conj	_	_
24	17	17	CD	CD	_	23	nummod	_	_
25	.	.	.	.	_	7	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	tested	test	VBN	VBN	_	14	advcl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	radioreceptor	radioreceptor	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
11	the	the	DT	DT	_	13	det	_	_
12	synthesized	synthesize	VBN	VBN	_	13	amod	_	_
13	compounds	compound	NNS	NNS	_	14	nsubj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	only	only	RB	RB	_	16	advmod	_	_
16	low	low	JJ	JJ	_	19	amod	_	_
17	relative	relative	JJ	JJ	_	19	amod	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	affinities	affinity	NNS	NNS	_	14	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	RBA	rba	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	to	to	TO	TO	_	26	case	_	_
24	type	type	NN	NN	_	26	compound	_	_
25	1	1	CD	CD	_	26	nummod	_	_
26	receptor	receptor	NN	NN	_	19	nmod	_	_
27	,	,	,	,	_	14	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	highest	highest	JJS	JJS	_	32	nsubj	_	_
30	being	be	VBG	VBG	_	32	cop	_	_
31	0.72	0.72	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	14	advcl	_	_
33	for	for	IN	IN	_	34	case	_	_
34	13	13	CD	CD	_	32	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	aldosterone	aldosterone	NN	NN	_	32	dep	_	_
37	=	=	JJ	JJ	_	36	amod	_	_
38	100	100	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	37	dep	_	_
40	)	)	-RRB-	-RRB-	_	36	punct	_	_
41	.	.	.	.	_	14	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	RBA	rba	NNS	NNS	_	9	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	system	system	NN	NN	_	5	nmod	_	_
9	were	be	VBD	VBD	_	0	root	_	_
10	:	:	:	:	_	9	punct	_	_
11	19-noraldosterone	19-noraldosterone	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	20	20	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	11	appos	_	_
15	;	;	:	:	_	11	punct	_	_
16	18-deoxyaldosterone	18-deoxyaldosterone	NN	NN	_	11	conj	_	_
17	,	,	,	,	_	16	punct	_	_
18	5.8	5.8	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	16	appos	_	_
20	;	;	:	:	_	11	punct	_	_
21	18-deoxy-19-noraldosterone	18-deoxy-19-noraldosterone	NN	NN	_	11	conj	_	_
22	,	,	,	,	_	21	punct	_	_
23	4.7	4.7	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	21	appos	_	_
25	;	;	:	:	_	11	punct	_	_
26	18,21-anhydroaldosterone	18,21-anhydroaldosterone	NN	NN	_	11	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	0.37	0.37	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	26	appos	_	_
30	;	;	:	:	_	11	punct	_	_
31	17-isoaldosterone	17-isoaldosterone	NN	NN	_	11	conj	_	_
32	,	,	,	,	_	31	punct	_	_
33	7.6	7.6	CD	CD	_	34	nummod	_	_
34	%	%	NN	NN	_	31	appos	_	_
35	and	and	CC	CC	_	11	cc	_	_
36	apoaldosterone	apoaldosterone	NN	NN	_	11	conj	_	_
37	,	,	,	,	_	36	punct	_	_
38	4.3	4.3	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	36	appos	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regimen	regimen	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	kidney-tonifying	kidney-tonifying	JJ	JJ	_	5	acl	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	qi-invigorating	qi-invigorating	JJ	JJ	_	7	conj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	aging	aging	NN	NN	_	12	compound	_	_
12	changes	change	NNS	NNS	_	2	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	12	nmod	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	plasma	plasma	NN	NN	_	4	compound	_	_
3	cortisol	cortisol	NN	NN	_	4	compound	_	_
4	concentration	concentration	NN	NN	_	19	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	sites	site	NNS	NNS	_	4	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	GCR	gcr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	measured	measure	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	24	case	_	_
21	32	32	CD	CD	_	24	nummod	_	_
22	healthy	healthy	JJ	JJ	_	24	amod	_	_
23	aged	aged	JJ	JJ	_	22	dep	_	_
24	persons	person	NNS	NNS	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	13	13	CD	CD	_	28	nummod	_	_
27	young	young	JJ	JJ	_	28	amod	_	_
28	adults	adult	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	animal	animal	JJ	JJ	_	3	amod	_	_
3	experiment	experiment	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	GCR	gcr	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	spleen	spleen	NN	NN	_	9	compound	_	_
8	lymphocytic	lymphocytic	JJ	JJ	_	9	amod	_	_
9	cell	cell	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	measured	measure	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	18	18	CD	CD	_	16	nummod	_	_
15	aged	aged	JJ	JJ	_	16	amod	_	_
16	rats	rat	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	9	9	CD	CD	_	20	nummod	_	_
19	young	young	JJ	JJ	_	20	amod	_	_
20	rats	rat	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	GCR	gcr	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	lower	lower	JJR	JJR	_	3	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	dep	_	_
11	aged	aged	JJ	JJ	_	12	amod	_	_
12	persons	person	NNS	NNS	_	8	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	rats	rat	NNS	NNS	_	12	conj	_	_
15	than	than	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	8	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	young	young	JJ	JJ	_	16	nmod	_	_
20	while	while	IN	IN	_	27	mark	_	_
21	the	the	DT	DT	_	24	det	_	_
22	plasma	plasma	NN	NN	_	24	compound	_	_
23	cortisol	cortisol	NN	NN	_	24	compound	_	_
24	level	level	NN	NN	_	27	nsubj	_	_
25	did	do	VBD	VBD	_	27	aux	_	_
26	n't	not	RB	RB	_	27	neg	_	_
27	change	change	VB	VB	_	8	advcl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	aging	aging	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	So	so	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	think	think	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	GCR	gcr	NN	NN	_	8	nsubj	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	sensitive	sensitive	JJ	JJ	_	3	ccomp	_	_
9	than	than	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	plasma	plasma	NN	NN	_	13	compound	_	_
12	cortisol	cortisol	NN	NN	_	13	compound	_	_
13	level	level	NN	NN	_	8	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	reflect	reflect	VB	VB	_	8	xcomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	aging	aging	NN	NN	_	18	compound	_	_
18	change	change	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	adrenal	adrenal	JJ	JJ	_	23	amod	_	_
22	cortex	cortex	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	treatment	treatment	NN	NN	_	21	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regimen	regimen	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Kidney-tonifying	kidney-tonifying	JJ	JJ	_	6	acl	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Qi-invigorating	qi-invigorating	JJ	JJ	_	8	conj	_	_
11	,	,	,	,	_	21	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	GCR	gcr	NN	NN	_	21	nsubjpass	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	dep	_	_
16	aged	aged	JJ	JJ	_	17	amod	_	_
17	persons	person	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	rats	rat	NNS	NNS	_	17	conj	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	enhanced	enhance	VBN	VBN	_	0	root	_	_
22	,	,	,	,	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	in	in	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	way	way	NN	NN	_	36	nmod	_	_
27	,	,	,	,	_	36	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	function	function	NN	NN	_	36	nsubjpass	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	aged	aged	JJ	JJ	_	34	amod	_	_
33	adrenal	adrenal	JJ	JJ	_	34	amod	_	_
34	cortex	cortex	NN	NN	_	29	nmod	_	_
35	was	be	VBD	VBD	_	36	auxpass	_	_
36	improved	improve	VBN	VBN	_	21	conj	_	_
37	.	.	.	.	_	21	punct	_	_

1	An	a	DT	DT	_	7	det	_	_
2	in	in	FW	FW	_	7	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	globin	globin	NN	NN	_	7	compound	_	_
5	gene	gene	NN	NN	_	7	compound	_	_
6	switching	switching	NN	NN	_	7	compound	_	_
7	model	model	NN	NN	_	0	root	_	_
8	based	base	VBN	VBN	_	7	acl	_	_
9	on	on	IN	IN	_	13	case	_	_
10	differentiated	differentiate	VBN	VBN	_	13	amod	_	_
11	embryonic	embryonic	JJ	JJ	_	13	amod	_	_
12	stem	stem	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	mouse	mouse	NN	NN	_	9	compound	_	_
4	embryonic	embryonic	JJ	JJ	_	9	amod	_	_
5	stem	stem	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	ES	es	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	cells	cell	NNS	NNS	_	2	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	study	study	VB	VB	_	2	advcl	_	_
12	globin	globin	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	11	dobj	_	_
14	expression	expression	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	switching	switching	NN	NN	_	13	conj	_	_
17	in	in	FW	FW	_	13	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	ES-derived	es-derived	JJ	JJ	_	6	amod	_	_
5	embryoid	embryoid	JJ	JJ	_	6	amod	_	_
6	bodies	body	NNS	NNS	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	2	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	full	full	JJ	JJ	_	10	amod	_	_
10	complement	complement	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	mouse	mouse	NN	NN	_	15	compound	_	_
13	embryonic	embryonic	JJ	JJ	_	15	amod	_	_
14	globin	globin	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	correct	correct	JJ	JJ	_	20	amod	_	_
19	temporal	temporal	JJ	JJ	_	18	dep	_	_
20	order	order	NN	NN	_	7	nmod	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	on	on	IN	IN	_	25	case	_	_
24	further	further	JJ	JJ	_	25	amod	_	_
25	differentiation	differentiation	NN	NN	_	29	nmod	_	_
26	,	,	,	,	_	29	punct	_	_
27	a	a	DT	DT	_	28	det	_	_
28	switch	switch	NN	NN	_	29	nsubj	_	_
29	occurs	occur	VBZ	VBZ	_	7	conj	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	fetal/adult	fetal/adult	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	erythroid-specific	erythroid-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	10	nsubjpass	_	_
8	NF-E1	nf-e1	NN	NN	_	7	dep	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	10	xcomp	_	_
14	coordinately	coordinately	RB	RB	_	13	advmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	globin	globin	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	embryoid	embryoid	JJ	JJ	_	21	amod	_	_
21	bodies	body	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	experiments	experiment	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	ES	es	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	system	system	NN	NN	_	11	nsubj	_	_
11	provides	provide	VBZ	VBZ	_	2	ccomp	_	_
12	a	a	DT	DT	_	14	det	_	_
13	good	good	JJ	JJ	_	14	amod	_	_
14	model	model	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	study	study	VB	VB	_	14	acl	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	development	development	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	18	advmod	_	_
2	the	the	DT	DT	_	4	dep	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	epsilon-	epsilon-	NN	NN	_	18	nsubjpass	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	beta-globin	beta-globin	NN	NN	_	4	conj	_	_
7	genes	gene	NNS	NNS	_	4	dep	_	_
8	driven	drive	VBN	VBN	_	4	acl	_	_
9	by	by	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	dominant	dominant	JJ	JJ	_	13	amod	_	_
12	control	control	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	DCR	dcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	introduced	introduce	VBN	VBN	_	37	advcl	_	_
19	into	into	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	system	system	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	37	punct	_	_
23	the	the	DT	DT	_	26	det	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	epsilon-globin	epsilon-globin	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	37	nsubjpass	_	_
27	,	,	,	,	_	26	punct	_	_
28	in	in	IN	IN	_	29	case	_	_
29	contrast	contrast	NN	NN	_	37	nmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	beta-globin	beta-globin	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	37	punct	_	_
35	is	be	VBZ	VBZ	_	37	auxpass	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	deregulated	deregulate	VBN	VBN	_	0	root	_	_
38	by	by	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	presence	presence	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	DCR	dcr	NN	NN	_	40	nmod	_	_
44	and	and	CC	CC	_	37	cc	_	_
45	is	be	VBZ	VBZ	_	46	auxpass	_	_
46	expressed	express	VBN	VBN	_	37	conj	_	_
47	strictly	strictly	RB	RB	_	46	advmod	_	_
48	as	as	IN	IN	_	51	case	_	_
49	an	a	DT	DT	_	51	det	_	_
50	embryonic	embryonic	JJ	JJ	_	51	amod	_	_
51	gene	gene	NN	NN	_	46	nmod	_	_
52	.	.	.	.	_	37	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	4	case	_	_
4	this	this	DT	DT	_	2	nmod	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	epsilon-globin	epsilon-globin	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	regulated	regulate	VBN	VBN	_	2	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	competition	competition	NN	NN	_	11	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	other	other	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	beta-globin	beta-globin	NN	NN	_	21	compound	_	_
21	locus	locus	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Oncogene	oncogene	NN	NN	_	2	compound	_	_
2	amplification	amplification	NN	NN	_	3	nsubj	_	_
3	correlates	correlate	VBZ	VBZ	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	dense	dense	JJ	JJ	_	7	amod	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	infiltration	infiltration	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	breast	breast	NN	NN	_	11	compound	_	_
11	cancers	cancer	NNS	NNS	_	7	nmod	_	_
12	:	:	:	:	_	3	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	3	parataxis	_	_
15	for	for	IN	IN	_	19	case	_	_
16	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
17	growth	growth	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	release	release	NN	NN	_	14	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	tumor	tumor	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	?	?	.	.	_	14	punct	_	_

1	One	one	CD	CD	_	3	compound	_	_
2	hundred	hundred	CD	CD	_	3	compound	_	_
3	six	six	CD	CD	_	7	nummod	_	_
4	primary	primary	JJ	JJ	_	7	amod	_	_
5	breast	breast	NN	NN	_	7	compound	_	_
6	cancer	cancer	NN	NN	_	7	compound	_	_
7	samples	sample	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	analysed	analyse	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	c-erbB2	c-erbb2	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	int-2	int-2	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	c-myc	c-myc	NN	NN	_	11	conj	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	amplification	amplification	NN	NN	_	11	dep	_	_
19	.	.	.	.	_	9	punct	_	_

1	Surgically	surgically	RB	RB	_	2	advmod	_	_
2	confirmed	confirm	VBN	VBN	_	4	amod	_	_
3	nodal	nodal	JJ	JJ	_	2	dep	_	_
4	involvement	involvement	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	42	42	CD	CD	_	9	compound	_	_
9	%	%	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Level	level	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	amplification	amplification	NN	NN	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	studied	study	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	Southern	southern	NN	NN	_	6	nmod	_	_
9	and/or	and/or	CC	CC	_	8	cc	_	_
10	slot	slot	NN	NN	_	8	conj	_	_
11	blot	blot	NN	NN	_	12	compound	_	_
12	techniques	technique	NNS	NNS	_	8	dep	_	_
13	.	.	.	.	_	6	punct	_	_

1	Amplified	amplify	VBN	VBN	_	4	amod	_	_
2	c-erbB2	c-erbb2	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	21.5	21.5	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	all	all	DT	DT	_	12	det	_	_
12	samples	sample	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Int-2	int-2	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	amplified	amplify	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	13.1	13.1	CD	CD	_	6	compound	_	_
6	%	%	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	c-myc	c-myc	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	amplified	amplify	VBN	VBN	_	3	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	10.3	10.3	CD	CD	_	13	compound	_	_
13	%	%	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	non-parametric	non-parametric	JJ	JJ	_	4	amod	_	_
4	test	test	NN	NN	_	13	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Kruskal-Wallis	kruskal-wallis	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	a	a	DT	DT	_	11	det	_	_
9	strong	strong	JJ	JJ	_	10	amod	_	_
10	negative	negative	JJ	JJ	_	11	amod	_	_
11	association	association	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	between	between	IN	IN	_	16	case	_	_
15	high	high	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	c-erbB2	c-erbb2	NN	NN	_	19	compound	_	_
19	amplification	amplification	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	absence	absence	NN	NN	_	16	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	estrogen	estrogen	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	ER	er	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	P	p	NN	NN	_	24	dep	_	_
30	=	=	JJ	JJ	_	29	amod	_	_
31	.0009	.0009	CD	CD	_	30	dep	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	or	or	CC	CC	_	24	cc	_	_
34	progesterone	progesterone	NN	NN	_	35	compound	_	_
35	receptor	receptor	NN	NN	_	24	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	PR	pr	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	P	p	NN	NN	_	35	dep	_	_
41	=	=	JJ	JJ	_	40	amod	_	_
42	.011	.011	CD	CD	_	41	dep	_	_
43	)	)	-RRB-	-RRB-	_	40	punct	_	_
44	expression	expression	NN	NN	_	24	dep	_	_
45	.	.	.	.	_	13	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlations	correlation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	6	case	_	_
6	all	all	DT	DT	_	4	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	high	high	JJ	JJ	_	6	conj	_	_
9	levels	level	NNS	NNS	_	6	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	amplification	amplification	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	each	each	DT	DT	_	14	det	_	_
14	oncogene	oncogene	NN	NN	_	11	nmod	_	_
15	separately	separately	RB	RB	_	16	advmod	_	_
16	or	or	CC	CC	_	6	advmod	_	_
17	combined	combine	VBN	VBN	_	16	conj	_	_
18	with	with	IN	IN	_	19	case	_	_
19	T	t	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	N	n	NN	NN	_	19	appos	_	_
22	,	,	,	,	_	19	punct	_	_
23	grade	grade	NN	NN	_	19	appos	_	_
24	,	,	,	,	_	19	punct	_	_
25	multifocality	multifocality	NN	NN	_	19	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	tumor	tumor	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	19	punct	_	_
29	or	or	CC	CC	_	19	cc	_	_
30	associated	associate	VBN	VBN	_	31	amod	_	_
31	carcinoma	carcinoma	NN	NN	_	19	conj	_	_
32	in	in	FW	FW	_	31	amod	_	_
33	situ	situ	FW	FW	_	32	dep	_	_
34	.	.	.	.	_	4	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	trend	trend	NN	NN	_	2	nsubj	_	_
5	approaching	approach	VBG	VBG	_	4	acl	_	_
6	statistical	statistical	JJ	JJ	_	7	amod	_	_
7	significance	significance	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	14	mark	_	_
9	patients	patient	NNS	NNS	_	14	nsubj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	c-erbB2	c-erbb2	NN	NN	_	12	compound	_	_
12	amplifications	amplification	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	have	have	VB	VB	_	4	acl	_	_
15	positive	positive	JJ	JJ	_	17	amod	_	_
16	lymph	lymph	NN	NN	_	17	compound	_	_
17	nodes	node	NNS	NNS	_	14	dobj	_	_
18	at	at	IN	IN	_	19	case	_	_
19	surgery	surgery	NN	NN	_	17	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	P	p	NN	NN	_	17	dep	_	_
22	=	=	JJ	JJ	_	21	amod	_	_
23	0.09	0.09	CD	CD	_	22	dep	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	somewhat	somewhat	RB	RB	_	3	advmod	_	_
3	surprising	surprising	JJ	JJ	_	4	amod	_	_
4	finding	finding	NN	NN	_	10	nsubj	_	_
5	however	however	RB	RB	_	10	advmod	_	_
6	was	be	VBD	VBD	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	very	very	RB	RB	_	9	advmod	_	_
9	strong	strong	JJ	JJ	_	10	amod	_	_
10	association	association	NN	NN	_	0	root	_	_
11	between	between	IN	IN	_	13	case	_	_
12	oncogene	oncogene	NN	NN	_	13	compound	_	_
13	amplification	amplification	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	dense	dense	JJ	JJ	_	17	amod	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	infiltration	infiltration	NN	NN	_	13	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	tumor	tumor	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	P	p	NN	NN	_	17	dep	_	_
23	=	=	JJ	JJ	_	22	amod	_	_
24	.05	.05	CD	CD	_	23	dep	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	correlation	correlation	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	even	even	RB	RB	_	5	advmod	_	_
5	stronger	stronger	JJR	JJR	_	0	root	_	_
6	when	when	WRB	WRB	_	13	advmod	_	_
7	only	only	RB	RB	_	9	advmod	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	13	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	amplification	amplification	NN	NN	_	9	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	considered	consider	VBN	VBN	_	5	advcl	_	_
14	,	,	,	,	_	13	punct	_	_
15	either	either	CC	CC	_	13	dep	_	_
16	for	for	IN	IN	_	18	case	_	_
17	each	each	DT	DT	_	18	det	_	_
18	oncogene	oncogene	NN	NN	_	13	conj	_	_
19	separately	separately	RB	RB	_	25	advmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	P	p	NN	NN	_	19	dep	_	_
22	=	=	JJ	JJ	_	21	amod	_	_
23	.0048	.0048	CD	CD	_	22	dep	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	or	or	CC	CC	_	13	advmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	combination	combination	NN	NN	_	25	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	P	p	NN	NN	_	27	dep	_	_
30	=	=	JJ	JJ	_	29	amod	_	_
31	.0007	.0007	CD	CD	_	30	dep	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	malignant	malignant	JJ	JJ	_	7	amod	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	help	help	VB	VB	_	2	ccomp	_	_
10	explain	explain	VB	VB	_	9	ccomp	_	_
11	this	this	DT	DT	_	12	det	_	_
12	observation	observation	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	NF	nf	NN	NN	_	7	compound	_	_
3	kappa	kappa	NN	NN	_	7	compound	_	_
4	B	b	NN	NN	_	7	compound	_	_
5	independent	independent	JJ	JJ	_	7	amod	_	_
6	cis-acting	cis-acting	JJ	JJ	_	7	amod	_	_
7	sequences	sequence	NNS	NNS	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
10	LTR	ltr	NN	NN	_	7	nmod	_	_
11	responsive	responsive	NN	NN	_	10	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rate	rate	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	initiation	initiation	NN	NN	_	2	nmod	_	_
6	directed	direct	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	long	long	JJ	JJ	_	11	amod	_	_
10	terminal	terminal	JJ	JJ	_	11	amod	_	_
11	repeat	repeat	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	LTR	ltr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	of	of	IN	IN	_	16	case	_	_
16	HIV-1	hiv-1	NN	NN	_	11	nmod	_	_
17	increases	increase	VBZ	VBZ	_	0	root	_	_
18	in	in	IN	IN	_	22	case	_	_
19	response	response	NN	NN	_	22	dep	_	_
20	to	to	TO	TO	_	22	case	_	_
21	mitogenic	mitogenic	JJ	JJ	_	22	amod	_	_
22	stimuli	stimulus	NNS	NNS	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	response	response	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
10	LTR	ltr	NN	NN	_	6	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	governed	govern	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	17	case	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	independent	independent	JJ	JJ	_	17	amod	_	_
17	sequences	sequence	NNS	NNS	_	13	nmod	_	_
18	located	located	JJ	JJ	_	17	amod	_	_
19	5'	5'	JJ	JJ	_	18	nmod	_	_
20	to	to	TO	TO	_	19	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	site	site	NN	NN	_	19	dep	_	_
23	of	of	IN	IN	_	26	case	_	_
24	transcription	transcription	NN	NN	_	26	compound	_	_
25	initiation	initiation	NN	NN	_	26	compound	_	_
26	sequences	sequence	NNS	NNS	_	22	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	bind	bind	VBP	VBP	_	26	acl:relcl	_	_
29	either	either	CC	CC	_	30	cc:preconj	_	_
30	NFAT-1	nfat-1	NN	NN	_	28	dobj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	NF	nf	NN	NN	_	34	compound	_	_
33	kappa	kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	30	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rate	rate	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	LTR-directed	ltr-directed	JJ	JJ	_	6	amod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	response	response	NN	NN	_	11	dep	_	_
10	to	to	TO	TO	_	11	case	_	_
11	treatment	treatment	NN	NN	_	7	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	either	either	CC	CC	_	16	cc:preconj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	11	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	tumor	tumor	NN	NN	_	21	compound	_	_
19	necrosis	necrosis	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	16	conj	_	_
22	if	if	IN	IN	_	33	mark	_	_
23	either	either	CC	CC	_	31	cc:preconj	_	_
24	the	the	DT	DT	_	31	det	_	_
25	NFAT-1	nfat-1	NN	NN	_	31	compound	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	NF	nf	NN	NN	_	29	compound	_	_
28	kappa	kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	25	conj	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	deleted	delete	VBN	VBN	_	7	advcl	_	_
34	,	,	,	,	_	7	punct	_	_
35	but	but	CC	CC	_	7	cc	_	_
36	failed	fail	VBD	VBD	_	7	conj	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	respond	respond	VB	VB	_	36	xcomp	_	_
39	to	to	TO	TO	_	42	case	_	_
40	these	these	DT	DT	_	42	det	_	_
41	mitogenic	mitogenic	JJ	JJ	_	42	amod	_	_
42	stimuli	stimulus	NNS	NNS	_	38	nmod	_	_
43	if	if	IN	IN	_	47	mark	_	_
44	both	both	DT	DT	_	45	det	_	_
45	sequences	sequence	NNS	NNS	_	47	nsubj	_	_
46	were	be	VBD	VBD	_	47	cop	_	_
47	absent	absent	JJ	JJ	_	38	advcl	_	_
48	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	HIV-1	hiv-1	NN	NN	_	4	compound	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	virus	virus	NN	NN	_	14	nsubj	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	NF	nf	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NFAT-1	nfat-1	NN	NN	_	9	conj	_	_
12	deletion	deletion	NN	NN	_	5	dobj	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	able	able	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	replicate	replicate	VB	VB	_	14	xcomp	_	_
17	although	although	IN	IN	_	23	mark	_	_
18	at	at	IN	IN	_	23	case	_	_
19	a	a	DT	DT	_	23	det	_	_
20	much	much	JJ	JJ	_	21	dep	_	_
21	decreased	decrease	VBN	VBN	_	23	amod	_	_
22	growth	growth	NN	NN	_	23	compound	_	_
23	rate	rate	NN	NN	_	16	advcl	_	_
24	,	,	,	,	_	14	punct	_	_
25	while	while	IN	IN	_	31	mark	_	_
26	the	the	DT	DT	_	27	det	_	_
27	deletion	deletion	NN	NN	_	31	nsubj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	NFAT-1	nfat-1	NN	NN	_	27	nmod	_	_
30	alone	alone	RB	RB	_	27	advmod	_	_
31	increased	increase	VBD	VBD	_	14	advcl	_	_
32	the	the	DT	DT	_	35	det	_	_
33	viral	viral	JJ	JJ	_	35	amod	_	_
34	growth	growth	NN	NN	_	35	compound	_	_
35	rate	rate	NN	NN	_	31	dobj	_	_
36	in	in	IN	IN	_	38	case	_	_
37	Jurkat	jurkat	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	deletion	deletion	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	nor	nor	CC	CC	_	2	cc	_	_
8	deletion	deletion	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NFAT-1	nfat-1	NN	NN	_	8	nmod	_	_
11	decreased	decrease	VBD	VBD	_	0	root	_	_
12	activation	activation	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	viral	viral	JJ	JJ	_	15	amod	_	_
15	replication	replication	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	phorbol	phorbol	NN	NN	_	18	compound	_	_
18	ester	ester	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	depletion	depletion	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	B-cell	b-cell	NN	NN	_	6	compound	_	_
6	population	population	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	2	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	aberrant	aberrant	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	human	human	JJ	JJ	_	17	amod	_	_
13	interferon	interferon	NN	NN	_	17	compound	_	_
14	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
15	factor	factor	NN	NN	_	17	compound	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	gene	gene	NN	NN	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	transgenic	transgenic	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Interferons	interferon	NNS	NNS	_	7	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFNs	ifn	NNS	NNS	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	well	well	RB	RB	_	7	advmod	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	both	both	CC	CC	_	11	cc:preconj	_	_
9	as	as	IN	IN	_	11	case	_	_
10	antiviral	antiviral	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	as	as	IN	IN	_	15	case	_	_
14	potent	potent	JJ	JJ	_	15	amod	_	_
15	regulators	regulator	NNS	NNS	_	11	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	cell	cell	NN	NN	_	15	nmod	_	_
18	growth	growth	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	differentiation	differentiation	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IFNs	ifn	NNS	NNS	_	5	nsubj	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	growth	growth	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	various	various	JJ	JJ	_	13	amod	_	_
9	normal	normal	JJ	JJ	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	transformed	transform	VBN	VBN	_	9	conj	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	types	type	NNS	NNS	_	6	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Previously	previously	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	28	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	IRF-1	irf-1	NN	NN	_	5	appos	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	interferon	interferon	NN	NN	_	11	compound	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	appos	_	_
12	1	1	CD	CD	_	11	nummod	_	_
13	)	)	-RRB-	-RRB-	_	11	punct	_	_
14	,	,	,	,	_	5	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
17	to	to	TO	TO	_	20	case	_	_
18	type	type	NN	NN	_	20	compound	_	_
19	I	i	CD	CD	_	20	nummod	_	_
20	IFN	ifn	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	some	some	DT	DT	_	25	det	_	_
23	IFN-inducible	ifn-inducible	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	promoters	promoter	NNS	NNS	_	20	conj	_	_
26	,	,	,	,	_	28	punct	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	identified	identify	VBN	VBN	_	0	root	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	cloned	clone	VBN	VBN	_	28	conj	_	_
31	.	.	.	.	_	28	punct	_	_

1	Since	since	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	IRF-1	irf-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	10	nsubj	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	virus	virus	NN	NN	_	10	nmod:npmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IFN	ifn	NN	NN	_	7	conj	_	_
10	inducible	inducible	JJ	JJ	_	16	advcl	_	_
11	,	,	,	,	_	16	punct	_	_
12	an	a	DT	DT	_	14	det	_	_
13	intriguing	intriguing	JJ	JJ	_	14	amod	_	_
14	issue	issue	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	raised	raise	VBN	VBN	_	0	root	_	_
17	as	as	IN	IN	_	24	mark	_	_
18	to	to	TO	TO	_	17	mwe	_	_
19	whether	whether	IN	IN	_	24	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IRF-1	irf-1	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	aux	_	_
24	functioning	function	VBG	VBG	_	16	advcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	IFN-mediated	ifn-mediated	JJ	JJ	_	27	amod	_	_
27	regulation	regulation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	cell	cell	NN	NN	_	27	nmod	_	_
30	growth	growth	NN	NN	_	29	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	differentiation	differentiation	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	generated	generate	VBD	VBD	_	0	root	_	_
7	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	6	dobj	_	_
9	carrying	carry	VBG	VBG	_	8	acl	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	IRF-1	irf-1	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	dobj	_	_
14	linked	link	VBN	VBN	_	13	acl	_	_
15	to	to	TO	TO	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	immunoglobulin	immunoglobulin	NN	NN	_	20	compound	_	_
19	heavy-chain	heavy-chain	JJ	JJ	_	20	amod	_	_
20	enhancer	enhancer	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	transgenic	transgenic	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	all	all	PDT	PDT	_	9	det:predet	_	_
7	the	the	DT	DT	_	9	det	_	_
8	lymphoid	lymphoid	JJ	JJ	_	9	amod	_	_
9	tissues	tissue	NNS	NNS	_	11	nsubj	_	_
10	examined	examine	VBN	VBN	_	9	acl	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	dramatic	dramatic	JJ	JJ	_	14	amod	_	_
14	reduction	reduction	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	number	number	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	11	punct	_	_

1	Preparation	preparation	NN	NN	_	12	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	analysis	analysis	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	bone	bone	NN	NN	_	7	compound	_	_
6	marrow	marrow	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	from	from	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	chimeric	chimeric	JJ	JJ	_	11	amod	_	_
11	mice	mouse	NNS	NNS	_	7	nmod	_	_
12	indicated	indicate	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	bone	bone	NN	NN	_	16	compound	_	_
16	marrow	marrow	NN	NN	_	20	nsubj	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	the	the	DT	DT	_	20	det	_	_
19	effective	effective	JJ	JJ	_	20	amod	_	_
20	site	site	NN	NN	_	12	ccomp	_	_
21	for	for	IN	IN	_	23	case	_	_
22	specific	specific	JJ	JJ	_	23	amod	_	_
23	depletion	depletion	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	B-cell	b-cell	NN	NN	_	27	compound	_	_
27	population	population	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	transgenic	transgenic	JJ	JJ	_	7	amod	_	_
5	bone	bone	NN	NN	_	7	compound	_	_
6	marrow	marrow	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	16	nsubj	_	_
8	cocultured	coculture	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	15	case	_	_
10	a	a	DT	DT	_	15	det	_	_
11	bone	bone	NN	NN	_	12	nmod:npmod	_	_
12	marrow-derived	marrow-derived	JJ	JJ	_	15	amod	_	_
13	stromal	stromal	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	revealed	reveal	VBD	VBD	_	0	root	_	_
17	an	a	DT	DT	_	21	det	_	_
18	altered	altered	JJ	JJ	_	21	amod	_	_
19	B-cell	b-cell	NN	NN	_	21	compound	_	_
20	maturation	maturation	NN	NN	_	21	compound	_	_
21	pattern	pattern	NN	NN	_	16	dobj	_	_
22	.	.	.	.	_	16	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cloning	cloning	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	TCF-1	tcf-1	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	11	det	_	_
8	T	t	NN	NN	_	9	nmod:npmod	_	_
9	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	5	appos	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	a	a	DT	DT	_	16	det	_	_
14	sequence-specific	sequence-specific	JJ	JJ	_	16	amod	_	_
15	HMG	hmg	NN	NN	_	16	compound	_	_
16	box	box	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	1	punct	_	_

1	CD3-epsilon	cd3-epsilon	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	controlled	control	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	downstream	downstream	JJ	JJ	_	11	amod	_	_
8	T	t	NN	NN	_	9	nmod:npmod	_	_
9	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	11	amod	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	4	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	identification	identification	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	T	t	NN	NN	_	8	nmod:npmod	_	_
8	cell-specific	cell-specific	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	TCF-1	tcf-1	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	binding	bind	VBG	VBG	_	10	acl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	element	element	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	multimerized	multimerized	JJ	JJ	_	4	amod	_	_
3	recognition	recognition	NN	NN	_	4	compound	_	_
4	motif	motif	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	TCF-1	tcf-1	NN	NN	_	4	nmod	_	_
7	constituted	constitute	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	T	t	NN	NN	_	10	nmod:npmod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	11	amod	_	_
11	enhancer	enhancer	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Subsequent	subsequent	JJ	JJ	_	2	amod	_	_
2	cloning	cloning	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TCF-1	tcf-1	NN	NN	_	2	nmod	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	three	three	CD	CD	_	8	nummod	_	_
7	splice	splice	NN	NN	_	8	compound	_	_
8	alternatives	alternative	NNS	NNS	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	nsubj	_	_
2	contained	contain	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	single	single	JJ	JJ	_	7	amod	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
6	HMG	hmg	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	2	dobj	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	closely	closely	RB	RB	_	10	advmod	_	_
10	related	related	JJ	JJ	_	7	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	similar	similar	JJ	JJ	_	13	amod	_	_
13	boxes	box	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	putative	putative	JJ	JJ	_	20	amod	_	_
17	mammalian	mammalian	JJ	JJ	_	20	amod	_	_
18	sex-determining	sex-determining	JJ	JJ	_	20	amod	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	SRY	sry	NN	NN	_	13	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	in	in	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	Schizosaccharomyces	schizosaccharomyces	FW	FW	_	29	compound	_	_
25	pombe	pombe	FW	FW	_	29	compound	_	_
26	Mc	mc	NN	NN	_	29	compound	_	_
27	mating	mating	NN	NN	_	29	compound	_	_
28	type	type	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	20	conj	_	_
30	.	.	.	.	_	2	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	dep	_	_
2	mRNA	mrna	NN	NN	_	4	advmod	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	uniquely	uniquely	RB	RB	_	4	advmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	cotransfection	cotransfection	NN	NN	_	9	nmod	_	_
3	into	into	IN	IN	_	5	case	_	_
4	non-T	non-t	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	TCF-1	tcf-1	NN	NN	_	9	nsubj	_	_
8	could	could	MD	MD	_	9	aux	_	_
9	transactivate	transactivate	VB	VB	_	0	root	_	_
10	through	through	IN	IN	_	13	case	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	cognate	cognate	JJ	JJ	_	13	amod	_	_
13	motif	motif	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	TCF-1	tcf-1	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	T	t	NN	NN	_	8	nmod:npmod	_	_
8	cell-specific	cell-specific	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	might	might	MD	MD	_	14	aux	_	_
14	play	play	VB	VB	_	10	acl:relcl	_	_
15	a	a	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	establishment	establishment	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	mature	mature	JJ	JJ	_	25	amod	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	phenotype	phenotype	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	proenkephalin	proenkephalin	NN	NN	_	7	compound	_	_
7	transcription	transcription	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	activation	activation	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	6	nsubj	_	_
6	accumulate	accumulate	VBP	VBP	_	0	root	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	neuropeptide	neuropeptide	NN	NN	_	12	compound	_	_
12	enkephalin	enkephalin	NN	NN	_	8	nmod	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	correlate	correlate	VBP	VBP	_	8	acl:relcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	high	high	JJ	JJ	_	17	amod	_	_
17	levels	level	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	proenkephalin	proenkephalin	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	basis	basis	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	changes	change	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proenkephalin	proenkephalin	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	GGGGACGTCCCC	ggggacgtcccc	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	named	name	VBN	VBN	_	7	acl	_	_
10	B2	b2	NN	NN	_	9	xcomp	_	_
11	,	,	,	,	_	7	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	similar	similar	JJ	JJ	_	7	acl:relcl	_	_
15	to	to	TO	TO	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	kappa	kappa	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	GGGGACTTTCC	ggggactttcc	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	the	the	DT	DT	_	24	det	_	_
23	binding	bind	VBG	VBG	_	24	amod	_	_
24	site	site	NN	NN	_	20	appos	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	24	nmod	_	_
29	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
30	factor	factor	NN	NN	_	35	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	NF	nf	NN	NN	_	35	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	-kappa	-kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	28	dep	_	_
36	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	an	a	DT	DT	_	10	det	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	nmod:npmod	_	_
8	B-like	b-like	JJ	JJ	_	10	amod	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	5	dobj	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	B2	b2	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	5	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	concomitant	concomitant	JJ	JJ	_	5	xcomp	_	_
17	with	with	IN	IN	_	18	case	_	_
18	activation	activation	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	proenkephalin	proenkephalin	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Mutations	mutation	NNS	NNS	_	6	nsubj	_	_
2	at	at	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	B2	b2	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	abolish	abolish	VBP	VBP	_	0	root	_	_
7	this	this	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	homodimer	homodimer	NN	NN	_	15	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	two	two	CD	CD	_	6	nummod	_	_
6	p50s	p50	NNS	NNS	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	subunit	subunit	NN	NN	_	3	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	binds	bind	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	18	det	_	_
17	B2	b2	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	proenkephalin	proenkephalin	NN	NN	_	18	nmod	_	_
21	relatively	relatively	RB	RB	_	22	advmod	_	_
22	better	better	JJR	JJR	_	15	advmod	_	_
23	than	than	IN	IN	_	24	dep	_	_
24	does	do	VBZ	VBZ	_	22	advcl	_	_
25	the	the	DT	DT	_	34	det	_	_
26	heterotetramer	heterotetramer	NN	NN	_	34	compound	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	two	two	CD	CD	_	29	nummod	_	_
29	p65s	p65	NNS	NNS	_	26	dep	_	_
30	plus	plus	CC	CC	_	29	cc	_	_
31	two	two	CD	CD	_	32	nummod	_	_
32	p50s	p50	NNS	NNS	_	29	conj	_	_
33	)	)	-RRB-	-RRB-	_	29	punct	_	_
34	form	form	NN	NN	_	24	nsubj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	factor	factor	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	T-cell-specific	t-cell-specific	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	14	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	proenkephalin	proenkephalin	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	4	ccomp	_	_
15	by	by	IN	IN	_	17	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	32	advmod	_	_
2	,	,	,	,	_	32	punct	_	_
3	as	as	IN	IN	_	7	mark	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	ubiquitous	ubiquitous	JJ	JJ	_	32	advcl	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	19	nsubj	_	_
12	through	through	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	B2	b2	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	11	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cell	cell	NN	NN	_	19	nmod:npmod	_	_
19	specific	specific	JJ	JJ	_	7	conj	_	_
20	,	,	,	,	_	32	punct	_	_
21	yet	yet	RB	RB	_	24	advmod	_	_
22	another	another	DT	DT	_	24	det	_	_
23	T-cell-specific	t-cell-specific	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	32	nsubjpass	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	synergizes	synergize	VBZ	VBZ	_	24	acl:relcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	nmod	_	_
30	should	should	MD	MD	_	32	aux	_	_
31	be	be	VB	VB	_	32	auxpass	_	_
32	considered	consider	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cis-linked	cis-linked	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	HLA	hla	NN	NN	_	11	compound	_	_
10	DRA	dra	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	6	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	transcription	transcription	NN	NN	_	2	nmod	_	_
14	in	in	FW	FW	_	13	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	consensus	consensus	NN	NN	_	3	compound	_	_
3	sequences	sequence	NNS	NNS	_	24	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	called	call	VBN	VBN	_	3	acl	_	_
6	X	x	NN	NN	_	5	xcomp	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Y	y	NN	NN	_	6	conj	_	_
9	boxes	box	NNS	NNS	_	6	dep	_	_
10	,	,	,	,	_	3	punct	_	_
11	capable	capable	JJ	JJ	_	3	amod	_	_
12	of	of	IN	IN	_	13	mark	_	_
13	binding	bind	VBG	VBG	_	11	advcl	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	13	dobj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	regulating	regulate	VBG	VBG	_	13	conj	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	defined	define	VBN	VBN	_	0	root	_	_
25	within	within	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	immediate	immediate	JJ	JJ	_	28	amod	_	_
28	upstream	upstream	JJ	JJ	_	29	amod	_	_
29	region	region	NN	NN	_	24	nmod	_	_
30	of	of	IN	IN	_	39	case	_	_
31	major	major	JJ	JJ	_	39	amod	_	_
32	histocompatibility	histocompatibility	NN	NN	_	39	compound	_	_
33	complex	complex	NN	NN	_	39	compound	_	_
34	(	(	-LRB-	-LRB-	_	39	punct	_	_
35	MHC	mhc	NN	NN	_	39	compound	_	_
36	)	)	-RRB-	-RRB-	_	39	punct	_	_
37	class	class	NN	NN	_	39	compound	_	_
38	II	ii	CD	CD	_	39	nummod	_	_
39	promoters	promoter	NNS	NNS	_	29	nmod	_	_
40	.	.	.	.	_	24	punct	_	_

1	Unlike	unlike	IN	IN	_	5	case	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	promoters	promoter	NNS	NNS	_	15	nmod	_	_
6	,	,	,	,	_	15	punct	_	_
7	the	the	DT	DT	_	13	det	_	_
8	HLA-DR	hla-dr	NN	NN	_	13	compound	_	_
9	alpha	alpha	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	DRA	dra	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	promoter	promoter	NN	NN	_	15	nsubj	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	contains	contain	VBZ	VBZ	_	0	root	_	_
16	one	one	CD	CD	_	17	nummod	_	_
17	element	element	NN	NN	_	15	dobj	_	_
18	identical	identical	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	``	``	``	``	_	23	punct	_	_
22	octamer	octamer	NN	NN	_	23	compound	_	_
23	motif	motif	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	immunoglobulin	immunoglobulin	NN	NN	_	28	compound	_	_
26	variable	variable	JJ	JJ	_	28	amod	_	_
27	region	region	NN	NN	_	28	compound	_	_
28	promoters	promoter	NNS	NNS	_	23	nmod	_	_
29	that	that	WDT	WDT	_	31	nsubj	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	responsible	responsible	JJ	JJ	_	17	acl:relcl	_	_
32	for	for	IN	IN	_	35	case	_	_
33	B	b	NN	NN	_	35	compound	_	_
34	cell-specific	cell-specific	JJ	JJ	_	35	amod	_	_
35	transcription	transcription	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	``	``	``	``	_	3	punct	_	_
3	octamer	octamer	NN	NN	_	9	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	context	context	NN	NN	_	9	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	DRA	dra	NN	NN	_	6	nmod	_	_
9	appears	appear	VBZ	VBZ	_	0	root	_	_
10	capable	capable	JJ	JJ	_	9	xcomp	_	_
11	of	of	IN	IN	_	12	mark	_	_
12	binding	bind	VBG	VBG	_	10	advcl	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	ubiquitous	ubiquitous	JJ	JJ	_	12	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	OTF-1	otf-1	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	lymphoid-specific	lymphoid-specific	JJ	JJ	_	27	amod	_	_
21	(	(	-LRB-	-LRB-	_	27	punct	_	_
22	OTF-2	otf-2	NN	NN	_	27	compound	_	_
23	)	)	-RRB-	-RRB-	_	27	punct	_	_
24	``	``	``	``	_	27	punct	_	_
25	octamer	octamer	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	15	conj	_	_
28	,	,	,	,	_	9	punct	_	_
29	but	but	CC	CC	_	9	cc	_	_
30	at	at	IN	IN	_	31	case	_	_
31	least	least	JJS	JJS	_	32	nmod:npmod	_	_
32	one	one	CD	CD	_	37	nummod	_	_
33	other	other	JJ	JJ	_	37	amod	_	_
34	distinct	distinct	JJ	JJ	_	33	dep	_	_
35	``	``	``	``	_	37	punct	_	_
36	octamer	octamer	NN	NN	_	37	compound	_	_
37	complex	complex	NN	NN	_	39	nsubjpass	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	found	find	VBN	VBN	_	9	conj	_	_
40	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	characterize	characterize	VB	VB	_	13	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	function	function	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cis-acting	cis-acting	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	developed	develop	VBN	VBN	_	0	root	_	_
14	an	a	DT	DT	_	17	det	_	_
15	in	in	FW	FW	_	17	amod	_	_
16	vitro	vitro	FW	FW	_	15	dep	_	_
17	system	system	NN	NN	_	13	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	25	nmod	_	_
20	a	a	DT	DT	_	23	det	_	_
21	DRA	dra	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	construct	construct	NN	NN	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	transcribed	transcribe	VBN	VBN	_	17	acl:relcl	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	efficiently	efficiently	RB	RB	_	25	advmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	extracts	extract	NNS	NNS	_	27	nmod	_	_
30	from	from	IN	IN	_	32	case	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	than	than	IN	IN	_	35	case	_	_
34	in	in	IN	IN	_	35	case	_	_
35	extracts	extract	NNS	NNS	_	29	nmod	_	_
36	from	from	IN	IN	_	40	case	_	_
37	class	class	NN	NN	_	40	compound	_	_
38	II-negative	ii-negative	JJ	JJ	_	40	amod	_	_
39	HeLa	hela	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	5'	5'	JJ	JJ	_	3	amod	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	constructs	construct	NNS	NNS	_	21	nsubj	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	lacked	lack	VBD	VBD	_	3	acl:relcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Y	y	NN	NN	_	8	compound	_	_
8	box	box	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	5	punct	_	_
10	but	but	CC	CC	_	5	cc	_	_
11	retained	retain	VBD	VBD	_	5	conj	_	_
12	the	the	DT	DT	_	15	det	_	_
13	``	``	``	``	_	15	punct	_	_
14	octamer	octamer	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	TATA	tata	NN	NN	_	18	compound	_	_
18	box	box	NN	NN	_	15	conj	_	_
19	were	be	VBD	VBD	_	21	cop	_	_
20	completely	completely	RB	RB	_	21	advmod	_	_
21	inactive	inactive	JJ	JJ	_	0	root	_	_
22	,	,	,	,	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	internal	internal	JJ	JJ	_	25	amod	_	_
25	deletion	deletion	NN	NN	_	30	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	Y	y	NN	NN	_	29	compound	_	_
29	box	box	NN	NN	_	25	nmod	_	_
30	reduced	reduce	VBD	VBD	_	21	conj	_	_
31	transcription	transcription	NN	NN	_	30	dobj	_	_
32	by	by	IN	IN	_	34	case	_	_
33	95	95	CD	CD	_	34	nummod	_	_
34	%	%	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	21	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	supercoiled	supercoiled	JJ	JJ	_	1	dobj	_	_
3	,	,	,	,	_	2	punct	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	linear	linear	JJ	JJ	_	2	conj	_	_
7	templates	template	NNS	NNS	_	2	dep	_	_
8	,	,	,	,	_	1	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	observed	observe	VBD	VBD	_	1	parataxis	_	_
11	differences	difference	NNS	NNS	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	efficiencies	efficiency	NNS	NNS	_	10	nmod	_	_
15	from	from	IN	IN	_	16	case	_	_
16	templates	template	NNS	NNS	_	14	nmod	_	_
17	lacking	lack	VBG	VBG	_	16	dep	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	disrupting	disrupt	VBG	VBG	_	17	conj	_	_
20	the	the	DT	DT	_	23	det	_	_
21	X	x	NN	NN	_	23	compound	_	_
22	consensus	consensus	NN	NN	_	23	compound	_	_
23	element	element	NN	NN	_	17	dobj	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	reflect	reflect	VBP	VBP	_	14	acl:relcl	_	_
26	effects	effect	NNS	NNS	_	25	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	random	random	JJ	JJ	_	29	amod	_	_
29	replacement	replacement	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	X	x	NN	NN	_	33	compound	_	_
32	box	box	NN	NN	_	33	compound	_	_
33	sequences	sequence	NNS	NNS	_	29	nmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	transient	transient	JJ	JJ	_	37	amod	_	_
36	expression	expression	NN	NN	_	37	compound	_	_
37	assays	assay	NNS	NNS	_	25	nmod	_	_
38	.	.	.	.	_	1	punct	_	_

1	Demonstration	demonstration	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	complete	complete	JJ	JJ	_	5	amod	_	_
5	dependence	dependence	NN	NN	_	1	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Y	y	NN	NN	_	9	compound	_	_
9	box	box	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	system	system	NN	NN	_	5	nmod	_	_
13	suggests	suggest	VBZ	VBZ	_	0	root	_	_
14	that	that	IN	IN	_	31	mark	_	_
15	,	,	,	,	_	31	punct	_	_
16	despite	despite	IN	IN	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	demonstrated	demonstrate	VBN	VBN	_	19	amod	_	_
19	importance	importance	NN	NN	_	31	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	DRA	dra	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	31	punct	_	_
25	the	the	DT	DT	_	28	det	_	_
26	DRA	dra	NN	NN	_	28	compound	_	_
27	``	``	``	``	_	28	punct	_	_
28	octamer	octamer	NN	NN	_	31	nsubj	_	_
29	does	do	VBZ	VBZ	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	utilize	utilize	VB	VB	_	13	ccomp	_	_
32	OTF-2	OTF-2	NNP	NNP	_	31	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	a	a	DT	DT	_	35	det	_	_
35	manner	manner	NN	NN	_	31	nmod	_	_
36	analogous	analogous	JJ	JJ	_	35	amod	_	_
37	to	to	TO	TO	_	39	case	_	_
38	immunoglobulin	immunoglobulin	NN	NN	_	39	compound	_	_
39	promoters	promoter	NNS	NNS	_	36	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	B	b	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	13	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	10	case	_	_
3	c-jun	c-jun	NN	NN	_	10	compound	_	_
4	,	,	,	,	_	3	punct	_	_
5	jun	jun	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	conj	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	jun	jun	NN	NN	_	9	compound	_	_
9	D	d	NN	NN	_	3	conj	_	_
10	proto-oncogenes	proto-oncogene	NNS	NNS	_	1	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	peripheral-blood	peripheral-blood	JJ	JJ	_	14	amod	_	_
14	granulocytes	granulocyte	NNS	NNS	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	purified	purify	VBN	VBN	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	peripheral-blood	peripheral-blood	JJ	JJ	_	8	amod	_	_
8	granulocytes	granulocyte	NNS	NNS	_	9	nsubj	_	_
9	express	express	VBP	VBP	_	3	ccomp	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	9	dobj	_	_
13	of	of	IN	IN	_	22	case	_	_
14	proto-oncogenes	proto-oncogene	NNS	NNS	_	22	compound	_	_
15	c-jun	c-jun	NN	NN	_	14	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	jun	jun	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	conj	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	jun	jun	NN	NN	_	21	compound	_	_
21	D	d	NN	NN	_	15	conj	_	_
22	mRNA	mrna	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	27	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	granulocytes	granulocyte	NNS	NNS	_	3	nmod	_	_
6	by	by	IN	IN	_	10	case	_	_
7	4	4	CD	CD	_	10	nummod	_	_
8	beta-phorbol	beta-phorbol	NN	NN	_	10	compound	_	_
9	12-myristate	12-myristate	NN	NN	_	10	compound	_	_
10	13-acetate	13-acetate	NN	NN	_	3	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMA	pma	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	27	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	levels	level	NNS	NNS	_	27	nsubjpass	_	_
17	of	of	IN	IN	_	25	case	_	_
18	c-jun	c-jun	NN	NN	_	25	compound	_	_
19	,	,	,	,	_	18	punct	_	_
20	jun	jun	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	conj	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	jun	jun	NN	NN	_	24	compound	_	_
24	D	d	NN	NN	_	18	conj	_	_
25	transcripts	transcript	NNS	NNS	_	16	nmod	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	increased	increase	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	three	three	CD	CD	_	4	nummod	_	_
3	jun	jun	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	similar	similar	JJ	JJ	_	9	amod	_	_
8	time	time	NN	NN	_	9	compound	_	_
9	course	course	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	induction	induction	NN	NN	_	5	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	PMA	pma	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	maximal	maximal	JJ	JJ	_	18	amod	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	20	nsubjpass	_	_
19	being	be	VBG	VBG	_	20	auxpass	_	_
20	reached	reach	VBN	VBN	_	5	advcl	_	_
21	after	after	IN	IN	_	23	case	_	_
22	60	60	CD	CD	_	23	nummod	_	_
23	min	min	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	induction	induction	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	expression	expression	NN	NN	_	17	nsubjpass	_	_
6	of	of	IN	IN	_	14	case	_	_
7	c-jun	c-jun	NN	NN	_	14	compound	_	_
8	,	,	,	,	_	7	punct	_	_
9	jun	jun	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	jun	jun	NN	NN	_	13	compound	_	_
13	D	d	NN	NN	_	7	conj	_	_
14	genes	gene	NNS	NNS	_	5	nmod	_	_
15	might	might	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	involved	involve	VBN	VBN	_	3	ccomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	terminal	terminal	JJ	JJ	_	21	amod	_	_
20	granulocyte	granulocyte	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	17	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	in	in	IN	IN	_	24	mark	_	_
24	regulating	regulate	VBG	VBG	_	21	conj	_	_
25	granulocyte	granulocyte	NN	NN	_	26	compound	_	_
26	functionality	functionality	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Oestrogen	oestrogen	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	ER	er	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	analysis	analysis	NN	NN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	B-cell	b-cell	NN	NN	_	11	compound	_	_
9	chronic	chronic	JJ	JJ	_	11	amod	_	_
10	lymphocytic	lymphocytic	JJ	JJ	_	11	amod	_	_
11	leukemia	leukemia	NN	NN	_	6	nmod	_	_
12	:	:	:	:	_	6	punct	_	_
13	correlation	correlation	NN	NN	_	6	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	biochemical	biochemical	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	immunocytochemical	immunocytochemical	JJ	JJ	_	15	conj	_	_
18	methods	method	NNS	NNS	_	15	dep	_	_
19	.	.	.	.	_	6	punct	_	_

1	Oestrogen	oestrogen	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	ER	er	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	present	present	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	neoplastic	neoplastic	JJ	JJ	_	11	amod	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	considered	consider	VBN	VBN	_	7	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	physiological	physiological	JJ	JJ	_	18	amod	_	_
18	marker	marker	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	growth	growth	NN	NN	_	21	compound	_	_
21	rate	rate	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	differentiation	differentiation	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	Tamoxifen	tamoxifen	NN	NN	_	9	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	oestrogen	oestrogen	NN	NN	_	5	compound	_	_
5	antagonist	antagonist	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	given	give	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	some	some	DT	DT	_	12	det	_	_
12	patients	patient	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	CLL	cll	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Hodgkin	hodgkin	NN	NN	_	18	nmod:poss	_	_
17	's	's	POS	POS	_	18	case	_	_
18	disease	disease	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	with	with	IN	IN	_	22	case	_	_
21	dramatic	dramatic	JJ	JJ	_	22	amod	_	_
22	response	response	NN	NN	_	9	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	single	single	JJ	JJ	_	25	amod	_	_
25	cases	case	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Until	until	IN	IN	_	2	case	_	_
2	now	now	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	ER	er	NN	NN	_	5	compound	_	_
5	status	status	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	assessed	assess	VBN	VBN	_	0	root	_	_
9	using	use	VBG	VBG	_	8	xcomp	_	_
10	a	a	DT	DT	_	13	det	_	_
11	steroid	steroid	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	assay	assay	NN	NN	_	9	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	SBA	sba	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	has	have	VBZ	VBZ	_	13	acl:relcl	_	_
19	many	many	JJ	JJ	_	21	amod	_	_
20	inherent	inherent	JJ	JJ	_	21	amod	_	_
21	problems	problem	NNS	NNS	_	18	dobj	_	_
22	.	.	.	.	_	8	punct	_	_

1	Recently	recently	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	development	development	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
8	directed	direct	VBN	VBN	_	7	acl	_	_
9	against	against	IN	IN	_	10	case	_	_
10	ER	er	NN	NN	_	8	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	applied	apply	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	study	study	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	breast	breast	NN	NN	_	19	compound	_	_
19	carcinomas	carcinoma	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	results	result	NNS	NNS	_	23	nsubj	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	show	show	VBP	VBP	_	13	conj	_	_
24	good	good	JJ	JJ	_	25	amod	_	_
25	correlation	correlation	NN	NN	_	23	dobj	_	_
26	with	with	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	quantitative	quantitative	JJ	JJ	_	29	amod	_	_
29	SBA	sba	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	49	49	CD	CD	_	4	nummod	_	_
4	cases	case	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	B-cell	b-cell	NN	NN	_	4	nmod	_	_
7	chronic	chronic	JJ	JJ	_	9	amod	_	_
8	lymphocytic	lymphocytic	JJ	JJ	_	9	amod	_	_
9	leukemia	leukemia	NN	NN	_	6	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CLL	cll	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	using	use	VBG	VBG	_	2	xcomp	_	_
14	immunostaining	immunostaining	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cytospin	cytospin	NN	NN	_	17	compound	_	_
17	preparations	preparation	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	30	30	CD	CD	_	14	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	cases	case	NNS	NNS	_	2	nmod	_	_
6	ER	er	NN	NN	_	8	compound	_	_
7	enzyme	enzyme	NN	NN	_	8	compound	_	_
8	immunoassay	immunoassay	NN	NN	_	14	nsubjpass	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ER-EIA	er-eia	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	performed	perform	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Cultured	culture	VBN	VBN	_	3	amod	_	_
2	MCF-7	mcf-7	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	24	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	derived	derive	VBN	VBN	_	3	dep	_	_
6	from	from	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	pleural	pleural	JJ	JJ	_	9	amod	_	_
9	effusion	effusion	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	breast	breast	NN	NN	_	14	compound	_	_
13	cancer	cancer	NN	NN	_	14	compound	_	_
14	patient	patient	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	known	know	VBN	VBN	_	5	dep	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	contain	contain	VB	VB	_	16	xcomp	_	_
19	high	high	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	ER	er	NN	NN	_	20	nmod	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	used	use	VBN	VBN	_	0	root	_	_
25	as	as	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	positive	positive	JJ	JJ	_	28	amod	_	_
28	control	control	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	34	punct	_	_
30	40-48	40-48	CD	CD	_	31	dep	_	_
31	%	%	NN	NN	_	34	dep	_	_
32	ER	er	NN	NN	_	34	compound	_	_
33	positive	positive	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	28	dep	_	_
35	by	by	IN	IN	_	36	case	_	_
36	immunocytochemistry	immunocytochemistry	NN	NN	_	34	nmod	_	_
37	;	;	:	:	_	34	punct	_	_
38	200	200	CD	CD	_	39	compound	_	_
39	fmol/mg	fmol/mg	NN	NN	_	40	amod	_	_
40	protein	protein	NN	NN	_	34	dep	_	_
41	by	by	IN	IN	_	42	case	_	_
42	EIA	eia	NN	NN	_	40	nmod	_	_
43	)	)	-RRB-	-RRB-	_	34	punct	_	_
44	.	.	.	.	_	24	punct	_	_

1	All	all	DT	DT	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CLL	cll	NN	NN	_	5	compound	_	_
5	cases	case	NNS	NNS	_	1	nmod	_	_
6	except	except	IN	IN	_	7	case	_	_
7	two	two	CD	CD	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	96	96	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	1	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	negative	negative	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	15	case	_	_
15	ER	er	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	less	less	JJR	JJR	_	13	dep	_	_
18	than	than	IN	IN	_	21	case	_	_
19	1	1	CD	CD	_	20	compound	_	_
20	%	%	NN	NN	_	21	amod	_	_
21	staining	staining	NN	NN	_	17	nmod	_	_
22	;	;	:	:	_	17	punct	_	_
23	less	less	JJR	JJR	_	17	dep	_	_
24	than	than	IN	IN	_	27	case	_	_
25	4	4	CD	CD	_	26	compound	_	_
26	fmol/mg	fmol/mg	NN	NN	_	27	amod	_	_
27	protein	protein	NN	NN	_	23	nmod	_	_
28	)	)	-RRB-	-RRB-	_	17	punct	_	_
29	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	positive	positive	JJ	JJ	_	4	amod	_	_
4	cases	case	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	granular	granular	JJ	JJ	_	8	amod	_	_
7	ER	er	NN	NN	_	8	compound	_	_
8	staining	staining	NN	NN	_	5	dobj	_	_
9	over	over	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	nucleus	nucleus	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	9.2	9.2	CD	CD	_	16	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	12.1	12.1	CD	CD	_	13	conj	_	_
16	%	%	NN	NN	_	5	dep	_	_
17	positive	positive	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	16	dep	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	and	and	CC	CC	_	5	cc	_	_
21	were	be	VBD	VBD	_	22	cop	_	_
22	positive	positive	JJ	JJ	_	5	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	EIA	eia	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	SBA	sba	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	i	i	LS	LS	_	12	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	patients	patient	NNS	NNS	_	12	nsubj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	CLL	cll	NN	NN	_	8	nmod	_	_
11	rarely	rarely	RB	RB	_	12	advmod	_	_
12	express	express	VBP	VBP	_	3	ccomp	_	_
13	ER	er	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	ii	ii	LS	LS	_	26	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	immunocytochemical	immunocytochemical	JJ	JJ	_	19	amod	_	_
19	staining	staining	NN	NN	_	26	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cytospin	cytospin	NN	NN	_	22	compound	_	_
22	preparations	preparation	NNS	NNS	_	19	nmod	_	_
23	is	be	VBZ	VBZ	_	26	cop	_	_
24	a	a	DT	DT	_	26	det	_	_
25	valid	valid	JJ	JJ	_	26	amod	_	_
26	technique	technique	NN	NN	_	12	conj	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	measurement	measurement	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	ER	er	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interest	interest	NN	NN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	one	one	CD	CD	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	positive	positive	JJ	JJ	_	10	amod	_	_
10	cases	case	NNS	NNS	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	diagnosed	diagnose	VBN	VBN	_	4	ccomp	_	_
13	as	as	IN	IN	_	14	case	_	_
14	CLL	CLL	NNP	NNP	_	12	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	Richter	richter	NN	NN	_	18	nmod:poss	_	_
17	's	's	POS	POS	_	18	case	_	_
18	transformation	transformation	NN	NN	_	14	nmod	_	_
19	confirming	confirm	VBG	VBG	_	18	acl	_	_
20	earlier	earlier	JJR	JJR	_	21	amod	_	_
21	findings	finding	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Thyroid	thyroid	NN	NN	_	3	compound	_	_
2	hormone	hormone	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	4	nsubj	_	_
4	form	form	VBP	VBP	_	0	root	_	_
5	distinct	distinct	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	protein-dependent	protein-dependent	JJ	JJ	_	4	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	independent	independent	JJ	JJ	_	7	conj	_	_
10	complexes	complex	NNS	NNS	_	7	dep	_	_
11	with	with	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	thyroid	thyroid	NN	NN	_	16	compound	_	_
14	hormone	hormone	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	4	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	recombinant	recombinant	JJ	JJ	_	13	amod	_	_
11	thyroid	thyroid	NN	NN	_	13	compound	_	_
12	hormone	hormone	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TRs	tr	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	to	to	TO	TO	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	palindromic	palindromic	JJ	JJ	_	23	amod	_	_
20	thyroid	thyroid	NN	NN	_	23	compound	_	_
21	hormone	hormone	NN	NN	_	23	compound	_	_
22	responsive	responsive	JJ	JJ	_	23	amod	_	_
23	element	element	NN	NN	_	5	nmod	_	_
24	AGGTCATGACCT	aggtcatgacct	NN	NN	_	23	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TREp	trep	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	using	use	VBG	VBG	_	3	xcomp	_	_
29	a	a	DT	DT	_	34	det	_	_
30	gel	gel	NN	NN	_	34	compound	_	_
31	electrophoretic	electrophoretic	JJ	JJ	_	34	amod	_	_
32	mobility	mobility	NN	NN	_	34	compound	_	_
33	shift	shift	NN	NN	_	34	compound	_	_
34	assay	assay	NN	NN	_	28	dobj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Four	four	CD	CD	_	4	nummod	_	_
2	specific	specific	JJ	JJ	_	4	amod	_	_
3	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
4	complexes	complex	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	after	after	IN	IN	_	8	case	_	_
8	incubation	incubation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	extracts	extract	NNS	NNS	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NE	ne	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	from	from	IN	IN	_	21	case	_	_
16	T3-responsive	t3-responsive	JJ	JJ	_	21	amod	_	_
17	pituitary	pituitary	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	GH3	gh3	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	cells	cell	NNS	NNS	_	11	nmod	_	_
22	with	with	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	TREp-containing	trep-containing	JJ	JJ	_	26	amod	_	_
25	DNA	dna	NN	NN	_	26	compound	_	_
26	fragment	fragment	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	compared	compare	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TREp	trep	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	reticulocyte	reticulocyte	NN	NN	_	11	compound	_	_
10	lysate-synthesized	lysate-synthesized	JJ	JJ	_	11	amod	_	_
11	TRs	tr	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	TR	tr	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	9	nsubj	_	_
3	1	1	CD	CD	_	2	nummod	_	_
4	and	and	CC	CC	_	2	cc	_	_
5	TR	tr	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	2	conj	_	_
7	2	2	CD	CD	_	6	nummod	_	_
8	each	each	DT	DT	_	2	dep	_	_
9	formed	form	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	16	det	_	_
11	single	single	JJ	JJ	_	16	amod	_	_
12	major	major	JJ	JJ	_	11	dep	_	_
13	TR	tr	NN	NN	_	16	compound	_	_
14	:	:	:	:	_	16	punct	_	_
15	TREp	trep	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	9	dobj	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	comigrated	comigrate	VBD	VBD	_	16	acl:relcl	_	_
19	with	with	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	least	least	RBS	RBS	_	23	advmod	_	_
22	retarded	retard	VBN	VBN	_	21	dep	_	_
23	complex	complex	NN	NN	_	18	nmod	_	_
24	formed	form	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	GH3	gh3	NN	NN	_	27	compound	_	_
27	NE	ne	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	9	punct	_	_
29	while	while	IN	IN	_	33	mark	_	_
30	TR	tr	NN	NN	_	31	compound	_	_
31	beta	beta	NN	NN	_	33	nsubj	_	_
32	1	1	CD	CD	_	31	nummod	_	_
33	formed	form	VBD	VBD	_	9	advcl	_	_
34	multiple	multiple	JJ	JJ	_	35	amod	_	_
35	complexes	complex	NNS	NNS	_	33	dobj	_	_
36	suggesting	suggest	VBG	VBG	_	33	xcomp	_	_
37	that	that	IN	IN	_	40	mark	_	_
38	it	it	PRP	PRP	_	40	nsubj	_	_
39	can	can	MD	MD	_	40	aux	_	_
40	bind	bind	VB	VB	_	36	ccomp	_	_
41	to	to	TO	TO	_	42	case	_	_
42	TREp	trep	NN	NN	_	40	nmod	_	_
43	as	as	IN	IN	_	45	case	_	_
44	an	a	DT	DT	_	45	det	_	_
45	oligomer	oligomer	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	9	punct	_	_

1	Interestingly	interestingly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	coincubation	coincubation	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	35S-TR	35s-tr	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	3	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	,	,	,	,	_	6	punct	_	_
9	GH3	gh3	NN	NN	_	10	compound	_	_
10	NE	ne	NNS	NNS	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	unlabeled	unlabeled	JJ	JJ	_	14	amod	_	_
14	TREp	trep	NN	NN	_	6	conj	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	15	nmod	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	only	only	RB	RB	_	16	dep	_	_
19	the	the	DT	DT	_	23	det	_	_
20	35S-TR	35s-tr	NN	NN	_	23	compound	_	_
21	:	:	:	:	_	23	punct	_	_
22	TREp	trep	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	but	but	CC	CC	_	16	cc	_	_
26	in	in	IN	IN	_	32	case	_	_
27	two	two	CD	CD	_	32	nummod	_	_
28	additional	additional	JJ	JJ	_	32	amod	_	_
29	more	more	RBR	RBR	_	30	advmod	_	_
30	greatly	greatly	RB	RB	_	32	advmod	_	_
31	retarded	retard	VBN	VBN	_	32	amod	_	_
32	complexes	complex	NNS	NNS	_	16	conj	_	_
33	containing	contain	VBG	VBG	_	32	dep	_	_
34	35S-TR	35s-tr	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	33	dobj	_	_
36	1	1	CD	CD	_	35	nummod	_	_
37	and	and	CC	CC	_	33	cc	_	_
38	comigrating	comigrate	VBG	VBG	_	33	conj	_	_
39	with	with	IN	IN	_	40	case	_	_
40	those	those	DT	DT	_	38	nmod	_	_
41	formed	form	VBN	VBN	_	40	acl	_	_
42	by	by	IN	IN	_	44	case	_	_
43	GH3	gh3	NN	NN	_	44	compound	_	_
44	extract	extract	NN	NN	_	41	nmod	_	_
45	alone	alone	RB	RB	_	44	advmod	_	_
46	.	.	.	.	_	15	punct	_	_

1	Incubation	incubation	NN	NN	_	24	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	each	each	DT	DT	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	TRs	tr	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	NE	ne	NNS	NNS	_	1	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	COS-7	cos-7	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	16	nsubj	_	_
14	do	do	VBP	VBP	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	possess	possess	VB	VB	_	11	acl:relcl	_	_
17	sufficient	sufficient	JJ	JJ	_	19	amod	_	_
18	endogenous	endogenous	JJ	JJ	_	17	dep	_	_
19	TRs	tr	NNS	NNS	_	16	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	mediate	mediate	VB	VB	_	19	acl	_	_
22	T3-responses	t3-response	NNS	NNS	_	21	dobj	_	_
23	,	,	,	,	_	1	punct	_	_
24	resulted	result	VBD	VBD	_	0	root	_	_
25	in	in	IN	IN	_	26	case	_	_
26	formation	formation	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	34	case	_	_
28	a	a	DT	DT	_	34	det	_	_
29	new	new	JJ	JJ	_	34	amod	_	_
30	,	,	,	,	_	34	punct	_	_
31	more	more	RBR	RBR	_	34	advmod	_	_
32	greatly	greatly	RB	RB	_	34	advmod	_	_
33	shifted	shift	VBN	VBN	_	34	amod	_	_
34	complex	complex	NN	NN	_	26	nmod	_	_
35	.	.	.	.	_	24	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	similar	similar	JJ	JJ	_	6	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	heat	heat	NN	NN	_	5	nmod:npmod	_	_
5	labile	labile	JJ	JJ	_	2	dep	_	_
6	activity	activity	NN	NN	_	18	nsubj	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	altered	alter	VBD	VBD	_	6	acl:relcl	_	_
9	mobility	mobility	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	TR	tr	NN	NN	_	15	compound	_	_
13	:	:	:	:	_	15	punct	_	_
14	TRE	tre	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	9	nmod	_	_
16	was	be	VBD	VBD	_	18	cop	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	present	present	JJ	JJ	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	NE	ne	NNS	NNS	_	18	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	T3-unresponsive	t3-unresponsive	JJ	JJ	_	24	amod	_	_
23	JEG-3	jeg-3	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	18	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	high	high	JJ	JJ	_	3	amod	_	_
3	concentration	concentration	NN	NN	_	17	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NE	ne	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	17	punct	_	_
7	all	all	DT	DT	_	17	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	TR	tr	NN	NN	_	7	nmod	_	_
11	bound	bind	VBN	VBN	_	7	acl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	TREp	trep	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	17	auxpass	_	_
15	more	more	JJR	JJR	_	16	dep	_	_
16	greatly	greatly	RB	RB	_	17	advmod	_	_
17	retarded	retard	VBN	VBN	_	0	root	_	_
18	than	than	IN	IN	_	21	case	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	absence	absence	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NE	ne	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	Truncation	truncation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TR	tr	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	nmod	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	at	at	IN	IN	_	8	case	_	_
7	amino	amino	NN	NN	_	8	compound	_	_
8	acid	acid	NN	NN	_	1	nmod	_	_
9	210	210	CD	CD	_	8	nummod	_	_
10	prevented	prevent	VBD	VBD	_	0	root	_	_
11	additional	additional	JJ	JJ	_	13	amod	_	_
12	complex	complex	NN	NN	_	13	compound	_	_
13	formation	formation	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NE	ne	NNS	NNS	_	16	nmod	_	_
19	without	without	IN	IN	_	20	mark	_	_
20	affecting	affect	VBG	VBG	_	10	advcl	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	10	punct	_	_
24	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
25	that	that	IN	IN	_	32	mark	_	_
26	the	the	DT	DT	_	27	det	_	_
27	carboxyl-terminus	carboxyl-terminus	NN	NN	_	32	nsubj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	TRs	tr	NNS	NNS	_	27	nmod	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	essential	essential	JJ	JJ	_	24	ccomp	_	_
33	for	for	IN	IN	_	34	case	_	_
34	interaction	interaction	NN	NN	_	32	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	proteins	protein	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	10	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Platelet-activating	platelet-activating	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	phospholipid	phospholipid	JJ	JJ	_	5	amod	_	_
5	turnover	turnover	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	calcium	calcium	NN	NN	_	8	compound	_	_
8	flux	flux	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	arachidonic	arachidonic	JJ	JJ	_	12	amod	_	_
11	acid	acid	NN	NN	_	12	compound	_	_
12	liberation	liberation	NN	NN	_	5	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	eicosanoid	eicosanoid	NN	NN	_	15	compound	_	_
15	generation	generation	NN	NN	_	5	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	oncogene	oncogene	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	5	conj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	5	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Platelet-activating	platelet-activating	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	mediator	mediator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Studies	study	NNS	NNS	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	actions	action	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	platelet-activating	platelet-activating	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	4	nmod	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	centered	center	VBN	VBN	_	0	root	_	_
10	mainly	mainly	RB	RB	_	12	advmod	_	_
11	around	around	IN	IN	_	12	case	_	_
12	neutrophils	neutrophil	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	monocytes	monocyte	NNS	NNS	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	platelets	platelet	NNS	NNS	_	12	conj	_	_
18	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	begin	begin	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	uncover	uncover	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	influence	influence	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	platelet-activating	platelet-activating	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	9	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Employing	employ	VBG	VBG	_	11	advcl	_	_
2	the	the	DT	DT	_	8	det	_	_
3	EBV-transformed	ebv-transformed	JJ	JJ	_	8	amod	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	B	b	NN	NN	_	8	compound	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	line	line	NN	NN	_	8	compound	_	_
8	SKW6.4	skw6.4	NN	NN	_	1	dobj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	platelet-activating	platelet-activating	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	16	nsubj	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	alters	alter	VBZ	VBZ	_	11	ccomp	_	_
17	membrane	membrane	NN	NN	_	19	compound	_	_
18	phospholipid	phospholipid	JJ	JJ	_	19	amod	_	_
19	metabolism	metabolism	NN	NN	_	16	dobj	_	_
20	indicated	indicate	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	incorporation	incorporation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	32P	32p	NN	NN	_	23	nmod	_	_
26	into	into	IN	IN	_	27	case	_	_
27	phosphatidylcholine	phosphatidylcholine	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	phosphatidylinositol	phosphatidylinositol	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	phosphatidic	phosphatidic	JJ	JJ	_	33	amod	_	_
33	acid	acid	NN	NN	_	27	conj	_	_
34	but	but	CC	CC	_	27	cc	_	_
35	not	not	RB	RB	_	36	dep	_	_
36	significantly	significantly	RB	RB	_	38	advmod	_	_
37	into	into	IN	IN	_	38	case	_	_
38	phosphatidylethanolamine	phosphatidylethanolamine	NN	NN	_	27	conj	_	_
39	at	at	IN	IN	_	40	case	_	_
40	concentrations	concentration	NNS	NNS	_	23	nmod	_	_
41	ranging	range	VBG	VBG	_	40	acl	_	_
42	from	from	IN	IN	_	43	case	_	_
43	10(-9)	10(-9)	CD	CD	_	46	nmod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	10(-6)	10(-6)	CD	CD	_	43	nmod	_	_
46	M	m	NN	NN	_	41	nmod	_	_
47	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inactive	inactive	JJ	JJ	_	3	amod	_	_
3	precursor	precursor	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	lyso-platelet-activating	lyso-platelet-activating	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	3	appos	_	_
7	,	,	,	,	_	3	punct	_	_
8	at	at	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	concentration	concentration	NN	NN	_	3	nmod	_	_
11	as	as	RB	RB	_	12	advmod	_	_
12	high	high	JJ	JJ	_	10	amod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	10(-7)	10(-7)	CD	CD	_	15	nummod	_	_
15	M	m	NN	NN	_	12	nmod	_	_
16	had	have	VBD	VBD	_	0	root	_	_
17	no	no	DT	DT	_	18	neg	_	_
18	effect	effect	NN	NN	_	16	dobj	_	_
19	on	on	IN	IN	_	20	case	_	_
20	any	any	DT	DT	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	membrane	membrane	NN	NN	_	24	compound	_	_
24	phospholipids	phospholipid	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	platelet-activating	platelet-activating	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	12	nsubj	_	_
7	from	from	IN	IN	_	11	case	_	_
8	10(-12)	10(-12)	CD	CD	_	10	compound	_	_
9	to	to	TO	TO	_	10	dep	_	_
10	10(-6)	10(-6)	CD	CD	_	11	nummod	_	_
11	M	m	NN	NN	_	6	nmod	_	_
12	induced	induce	VBD	VBD	_	3	ccomp	_	_
13	rapid	rapid	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	significant	significant	JJ	JJ	_	13	conj	_	_
16	elevation	elevation	NN	NN	_	12	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	levels	level	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	whereas	whereas	IN	IN	_	12	dep	_	_
23	lyso-platelet-activating	lyso-platelet-activating	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	27	nsubj	_	_
25	was	be	VBD	VBD	_	27	cop	_	_
26	again	again	RB	RB	_	27	advmod	_	_
27	ineffective	ineffective	JJ	JJ	_	12	parataxis	_	_
28	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	impact	impact	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	platelet-activating	platelet-activating	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	binding	bind	VBG	VBG	_	8	acl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	measuring	measure	VBG	VBG	_	3	advcl	_	_
15	platelet-activating	platelet-activating	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	17	nmod:npmod	_	_
17	induced	induced	JJ	JJ	_	20	amod	_	_
18	arachidonic	arachidonic	JJ	JJ	_	20	amod	_	_
19	acid	acid	NN	NN	_	20	compound	_	_
20	release	release	NN	NN	_	14	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	5-hydroxyeicosatetraenoic	5-hydroxyeicosatetraenoic	JJ	JJ	_	24	amod	_	_
23	acid	acid	NN	NN	_	24	compound	_	_
24	production	production	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	platelet-activating	platelet-activating	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	inducing	induce	VBG	VBG	_	6	advcl	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	proto-oncogenes	proto-oncogene	NNS	NNS	_	9	nmod	_	_
14	c-fos	c-fos	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	c-jun	c-jun	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	explored	explore	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	possible	possible	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	5-hydroxyeicosatetraenoic	5-hydroxyeicosatetraenoic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	6	nmod	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	regulator	regulator	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	arachidonic	arachidonic	JJ	JJ	_	16	amod	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	liberation	liberation	NN	NN	_	12	nmod	_	_
17	demonstrating	demonstrate	VBG	VBG	_	3	xcomp	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	endogenous	endogenous	JJ	JJ	_	21	amod	_	_
20	5-lipoxygenase	5-lipoxygenase	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	22	nsubj	_	_
22	modulates	modulate	VBZ	VBZ	_	17	ccomp	_	_
23	platelet-activating	platelet-activating	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	25	nmod:npmod	_	_
25	induced	induced	JJ	JJ	_	28	amod	_	_
26	arachidonic	arachidonic	JJ	JJ	_	28	amod	_	_
27	acid	acid	NN	NN	_	28	compound	_	_
28	release	release	NN	NN	_	22	dobj	_	_
29	perhaps	perhaps	RB	RB	_	30	advmod	_	_
30	acting	act	VBG	VBG	_	22	xcomp	_	_
31	at	at	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	level	level	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	phospholipase	phospholipase	NN	NN	_	36	compound	_	_
36	A2	a2	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	platelet-activating	platelet-activating	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	here	here	RB	RB	_	7	advmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	have	have	VB	VB	_	7	xcomp	_	_
11	a	a	DT	DT	_	15	det	_	_
12	direct	direct	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	profound	profound	JJ	JJ	_	12	conj	_	_
15	effect	effect	NN	NN	_	10	dobj	_	_
16	on	on	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	pure	pure	JJ	JJ	_	21	amod	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	10	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	bronchial	bronchial	JJ	JJ	_	12	amod	_	_
12	asthma	asthma	NN	NN	_	9	nmod	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Quantitation	quantitation	NN	NN	_	20	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GCR	gcr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	the	the	DT	DT	_	10	det	_	_
10	study	study	NN	NN	_	1	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
13	affinity	affinity	NN	NN	_	10	nmod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	glucocorticosteroids	glucocorticosteroid	NNS	NNS	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	GCS	gc	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	made	make	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
23	blood	blood	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	31	case	_	_
26	bronchial	bronchial	JJ	JJ	_	27	amod	_	_
27	asthma	asthma	NN	NN	_	31	compound	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	BA	ba	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	patients	patient	NNS	NNS	_	24	nmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	consideration	consideration	NN	NN	_	20	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	GCR	gcr	NN	NN	_	36	compound	_	_
36	treatment	treatment	NN	NN	_	33	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	serum	serum	NN	NN	_	39	compound	_	_
39	levels	level	NNS	NNS	_	36	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	endogenous	endogenous	JJ	JJ	_	42	amod	_	_
42	cortisol	cortisol	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	20	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	stated	state	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	GCR	gcr	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	healthy	healthy	JJ	JJ	_	8	amod	_	_
8	controls	control	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GCS-untreated	gcs-untreated	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	8	conj	_	_
12	outnumbered	outnumber	VBD	VBD	_	3	ccomp	_	_
13	those	those	DT	DT	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	cortisol-dependent	cortisol-dependent	JJ	JJ	_	17	amod	_	_
16	BA	ba	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	13	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	hormone	hormone	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Following	follow	VBG	VBG	_	2	amod	_	_
2	discontinuation	discontinuation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
5	drugs	drug	NNS	NNS	_	7	compound	_	_
6	GCR	gcr	NN	NN	_	7	compound	_	_
7	count	count	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cortisol-dependent	cortisol-dependent	JJ	JJ	_	10	amod	_	_
10	BA	ba	NN	NN	_	7	nmod	_	_
11	tends	tend	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	rise	rise	VB	VB	_	11	xcomp	_	_
14	.	.	.	.	_	11	punct	_	_

1	Endogenous	endogenous	JJ	JJ	_	2	amod	_	_
2	cortisol	cortisol	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	no	no	DT	DT	_	5	neg	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	on	on	IN	IN	_	8	case	_	_
7	GCR	gcr	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	3	nmod	_	_
9	estimated	estimate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	3H-triamcinolone	3h-triamcinolone	NN	NN	_	12	compound	_	_
12	acetonide	acetonide	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	HIV-1	hiv-1	NN	NN	_	0	root	_	_
4	isolate	isolate	JJ	JJ	_	3	amod	_	_
5	containing	contain	VBG	VBG	_	3	acl	_	_
6	alterations	alteration	NNS	NNS	_	5	dobj	_	_
7	affecting	affect	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	clones	clone	NNS	NNS	_	16	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HIV-1	hiv-1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	derived	derive	VBN	VBN	_	3	acl	_	_
8	from	from	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	single	single	JJ	JJ	_	11	amod	_	_
11	isolate	isolate	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AL1	al1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	3	punct	_	_
16	exhibited	exhibit	VBD	VBD	_	0	root	_	_
17	distinct	distinct	JJ	JJ	_	21	amod	_	_
18	replicative	replicative	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cytopathic	cytopathic	JJ	JJ	_	18	conj	_	_
21	properties	property	NNS	NNS	_	16	dobj	_	_
22	during	during	IN	IN	_	23	case	_	_
23	propagation	propagation	NN	NN	_	16	nmod	_	_
24	in	in	IN	IN	_	29	case	_	_
25	a	a	DT	DT	_	29	det	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	phenotypic	phenotypic	JJ	JJ	_	3	amod	_	_
3	differences	difference	NNS	NNS	_	6	nsubj	_	_
4	observed	observe	VBN	VBN	_	3	acl	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	attributable	attributable	JJ	JJ	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	large	large	JJ	JJ	_	10	amod	_	_
10	part	part	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	to	to	TO	TO	_	13	case	_	_
13	changes	change	NNS	NNS	_	6	nmod	_	_
14	affecting	affect	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	LTR	ltr	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Nucleotide	nucleotide	NN	NN	_	2	compound	_	_
2	sequence	sequence	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	PCR	pcr	NN	NN	_	5	compound	_	_
5	analyses	analysis	NNS	NNS	_	2	conj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	novel	novel	JJ	JJ	_	11	amod	_	_
11	duplications	duplication	NNS	NNS	_	8	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	deletions	deletion	NNS	NNS	_	11	conj	_	_
14	involving	involve	VBG	VBG	_	11	acl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	changes	change	NNS	NNS	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	original	original	JJ	JJ	_	14	amod	_	_
12	AL1	al1	NN	NN	_	14	compound	_	_
13	virus	virus	NN	NN	_	14	compound	_	_
14	stock	stock	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Subcloning	subcloning	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	variant	variant	JJ	JJ	_	7	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	segments	segment	NNS	NNS	_	1	nmod	_	_
8	into	into	IN	IN	_	12	case	_	_
9	LTR-driven	ltr-driven	JJ	JJ	_	12	amod	_	_
10	CAT	cat	NN	NN	_	12	compound	_	_
11	expression	expression	NN	NN	_	12	compound	_	_
12	vectors	vector	NNS	NNS	_	1	nmod	_	_
13	confirmed	confirm	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	correlation	correlation	NN	NN	_	13	dobj	_	_
16	between	between	IN	IN	_	18	case	_	_
17	promoter	promoter	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	replicative/cytopathic	replicative/cytopathic	JJ	JJ	_	21	amod	_	_
21	capacity	capacity	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	13	punct	_	_

1	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	4	compound	_	_
2	D3	d3	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	RNA	rna	NN	NN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	expression	expression	NN	NN	_	4	dep	_	_
7	in	in	IN	IN	_	9	case	_	_
8	hematopoietic	hematopoietic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	2	compound	_	_
2	D3	d3	NN	NN	_	6	nsubj	_	_
3	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	appos	_	_
5	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	differentiation	differentiation	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	inhibits	inhibit	VBZ	VBZ	_	6	conj	_	_
10	proliferation	proliferation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
13	leukemic	leukemic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	various	various	JJ	JJ	_	17	amod	_	_
17	lines	line	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	patients	patient	NNS	NNS	_	17	conj	_	_
20	;	;	:	:	_	6	punct	_	_
21	these	these	DT	DT	_	22	det	_	_
22	effects	effect	NNS	NNS	_	25	nsubjpass	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	probably	probably	RB	RB	_	25	advmod	_	_
25	mediated	mediate	VBN	VBN	_	6	parataxis	_	_
26	through	through	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	25	punct	_	_

1	Little	little	JJ	JJ	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	expression	expression	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	RNA	rna	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	modulation	modulation	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	expression	expression	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	RNA	rna	NN	NN	_	4	nmod	_	_
13	in	in	IN	IN	_	19	case	_	_
14	various	various	JJ	JJ	_	19	amod	_	_
15	proliferating	proliferate	VBG	VBG	_	19	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	nonproliferating	nonproliferating	JJ	JJ	_	15	conj	_	_
18	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	4	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	RNA	rna	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	various	various	JJ	JJ	_	11	amod	_	_
11	kinds	kind	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	hematopoietic	hematopoietic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	17	case	_	_
17	macrophages	macrophage	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	17	conj	_	_
22	,	,	,	,	_	14	punct	_	_
23	as	as	RB	RB	_	11	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	in	in	IN	IN	_	28	case	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	11	conj	_	_
29	KG-1	kg-1	NN	NN	_	28	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	myeloblasts	myeloblast	NNS	NNS	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	29	punct	_	_
34	HL-60	hl-60	NN	NN	_	29	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	promyelocytes	promyelocyte	NNS	NNS	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	,	,	,	,	_	29	punct	_	_
39	ML-3	ml-3	NN	NN	_	29	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	myelomonoblasts	myelomonoblast	NNS	NNS	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	29	punct	_	_
44	U937	u937	NN	NN	_	29	conj	_	_
45	,	,	,	,	_	29	punct	_	_
46	THP-1	thp-1	NN	NN	_	29	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	monoblasts	monoblast	NNS	NNS	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	,	,	,	,	_	29	punct	_	_
51	K562	k562	NN	NN	_	29	conj	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	erythroblasts	erythroblast	NNS	NNS	_	51	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	,	,	,	,	_	29	punct	_	_
56	and	and	CC	CC	_	29	cc	_	_
57	S-LB1	s-lb1	NN	NN	_	29	conj	_	_
58	(	(	-LRB-	-LRB-	_	61	punct	_	_
59	HTLV-1-transfected	htlv-1-transfected	JJ	JJ	_	61	amod	_	_
60	T	t	NN	NN	_	61	compound	_	_
61	lymphocytes	lymphocyte	NNS	NNS	_	57	appos	_	_
62	)	)	-RRB-	-RRB-	_	61	punct	_	_
63	.	.	.	.	_	8	punct	_	_

1	Receptor	receptor	NN	NN	_	2	compound	_	_
2	transcripts	transcript	NNS	NNS	_	5	nsubj	_	_
3	were	be	VBD	VBD	_	5	cop	_	_
4	4.6	4.6	CD	CD	_	5	nummod	_	_
5	kilobases	kilobase	NNS	NNS	_	0	root	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	kb	kb	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	no	no	DT	DT	_	13	neg	_	_
12	variant	variant	JJ	JJ	_	13	amod	_	_
13	sizes	size	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	observed	observe	VBN	VBN	_	5	conj	_	_
16	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	9	nsubj	_	_
4	examined	examine	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	group	group	NN	NN	_	4	nmod	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	expressed	express	VBD	VBD	_	0	root	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	Most	most	JJS	JJS	_	4	amod	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	negligible	negligible	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	RNA	rna	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	protein	protein	NN	NN	_	11	conj	_	_
14	;	;	:	:	_	5	punct	_	_
15	however	however	RB	RB	_	5	advmod	_	_
16	;	;	:	:	_	5	punct	_	_
17	analysis	analysis	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	lymphoid/myeloid	lymphoid/myeloid	JJ	JJ	_	22	amod	_	_
21	somatic	somatic	JJ	JJ	_	22	amod	_	_
22	hybrid	hybrid	NN	NN	_	17	nmod	_	_
23	suggested	suggest	VBD	VBD	_	5	parataxis	_	_
24	that	that	IN	IN	_	39	mark	_	_
25	suppression	suppression	NN	NN	_	39	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	expression	expression	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	31	compound	_	_
30	receptor	receptor	NN	NN	_	31	compound	_	_
31	RNA	rna	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
35	may	may	MD	MD	_	39	aux	_	_
36	be	be	VB	VB	_	39	cop	_	_
37	a	a	DT	DT	_	39	det	_	_
38	dominant	dominant	JJ	JJ	_	39	amod	_	_
39	characteristic	characteristic	NN	NN	_	23	ccomp	_	_
40	.	.	.	.	_	5	punct	_	_

1	HL-60	hl-60	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	cultured	culture	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	10(-7)	10(-7)	CD	CD	_	7	nummod	_	_
7	mol/L	mol/l	NN	NN	_	4	nmod	_	_
8	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	7	dep	_	_
9	for	for	IN	IN	_	13	case	_	_
10	24	24	CD	CD	_	12	compound	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	72	72	CD	CD	_	13	nummod	_	_
13	hours	hour	NNS	NNS	_	4	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	levels	level	NNS	NNS	_	26	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	expression	expression	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	RNA	rna	NN	NN	_	21	conj	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	examined	examine	VBN	VBN	_	4	conj	_	_
27	.	.	.	.	_	4	punct	_	_

1	Levels	level	NNS	NNS	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	RNA	rna	NN	NN	_	1	nmod	_	_
4	coding	coding	NN	NN	_	3	dep	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	receptor	receptor	NN	NN	_	4	nmod	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	modulated	modulate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	exposure	exposure	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	ligand	ligand	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Levels	level	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	occupied	occupy	VBN	VBN	_	6	amod	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	nmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	HL-60	hl-60	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	;	;	:	:	_	7	punct	_	_
13	but	but	CC	CC	_	7	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	total	total	JJ	JJ	_	16	amod	_	_
16	number	number	NN	NN	_	20	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	16	nmod	_	_
20	decreased	decrease	VBD	VBD	_	7	conj	_	_
21	about	about	RB	RB	_	22	advmod	_	_
22	50	50	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	20	dobj	_	_
24	at	at	IN	IN	_	26	case	_	_
25	24	24	CD	CD	_	26	nummod	_	_
26	hours	hour	NNS	NNS	_	20	nmod	_	_
27	and	and	CC	CC	_	20	cc	_	_
28	returned	return	VBD	VBD	_	20	conj	_	_
29	toward	toward	IN	IN	_	30	case	_	_
30	normal	normal	JJ	JJ	_	28	nmod	_	_
31	at	at	IN	IN	_	33	case	_	_
32	72	72	CD	CD	_	33	nummod	_	_
33	hours	hour	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Steady-state	steady-state	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	RNA	rna	NN	NN	_	2	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	affected	affect	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	terminal	terminal	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HL-60	hl-60	NN	NN	_	12	nmod	_	_
15	toward	toward	IN	IN	_	17	case	_	_
16	either	either	CC	CC	_	17	cc:preconj	_	_
17	granulocytes	granulocyte	NNS	NNS	_	12	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	macrophages	macrophage	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Nondividing	nondividing	JJ	JJ	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	7	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	normal	normal	JJ	JJ	_	5	amod	_	_
5	individuals	individual	NNS	NNS	_	2	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	expressed	express	VBD	VBD	_	0	root	_	_
8	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	RNA	rna	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	nondividing	nondividing	JJ	JJ	_	7	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	13	nsubj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	individuals	individual	NNS	NNS	_	7	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	express	express	VB	VB	_	0	root	_	_
14	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	RNA	rna	NN	NN	_	13	dobj	_	_
17	;	;	:	:	_	13	punct	_	_
18	with	with	IN	IN	_	19	case	_	_
19	stimulation	stimulation	NN	NN	_	31	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	proliferation	proliferation	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	31	punct	_	_
26	accumulation	accumulation	NN	NN	_	31	nsubj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	30	compound	_	_
29	receptor	receptor	NN	NN	_	30	compound	_	_
30	RNA	rna	NN	NN	_	26	nmod	_	_
31	increased	increase	VBD	VBD	_	13	parataxis	_	_
32	markedly	markedly	RB	RB	_	31	advmod	_	_
33	.	.	.	.	_	31	punct	_	_

1	Half-life	half-life	NN	NN	_	13	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	t1/2	t1/2	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	of	of	IN	IN	_	8	case	_	_
6	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	RNA	rna	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	short	short	JJ	JJ	_	0	root	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	1	1	CD	CD	_	16	nummod	_	_
16	hour	hour	NN	NN	_	13	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	determined	determine	VBN	VBN	_	13	advcl	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	measuring	measure	VBG	VBG	_	19	advcl	_	_
22	decay	decay	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	message	message	NN	NN	_	22	nmod	_	_
26	after	after	IN	IN	_	27	case	_	_
27	addition	addition	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	actinomycin	actinomycin	NN	NN	_	30	compound	_	_
30	D	d	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	Consistent	consistent	JJ	JJ	_	12	ccomp	_	_
2	with	with	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	short	short	JJ	JJ	_	5	amod	_	_
5	t1/2	t1/2	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	accumulation	accumulation	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	RNA	rna	NN	NN	_	7	nmod	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	cells	cell	NNS	NNS	_	12	nmod	_	_
15	as	as	IN	IN	_	20	mark	_	_
16	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	synthesis	synthesis	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	inhibited	inhibit	VBN	VBN	_	12	advcl	_	_
21	.	.	.	.	_	12	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	understand	understand	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	physiologic	physiologic	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	proliferating	proliferate	VBG	VBG	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	on	on	IN	IN	_	5	case	_	_
4	mononuclear	mononuclear	JJ	JJ	_	5	amod	_	_
5	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	Alzheimer	alzheimer	NN	NN	_	9	nmod:poss	_	_
8	's	's	POS	POS	_	9	case	_	_
9	disease	disease	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	lines	line	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	evidence	evidence	NN	NN	_	2	nmod	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	disturbances	disturbance	NNS	NNS	_	5	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HPA	hpa	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	system	system	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	Alzheimer	alzheimer	NN	NN	_	17	nmod:poss	_	_
16	's	's	POS	POS	_	17	case	_	_
17	disease	disease	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	AD	ad	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	exploration	exploration	NN	NN	_	23	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	potential	potential	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	GR	gr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	AD	ad	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	23	punct	_	_
18	GR	gr	NN	NN	_	23	nsubjpass	_	_
19	density	density	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	affinity	affinity	NN	NN	_	18	conj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	assessed	assess	VBN	VBN	_	0	root	_	_
24	on	on	IN	IN	_	26	case	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	12	12	CD	CD	_	30	nummod	_	_
29	AD	ad	NN	NN	_	30	compound	_	_
30	patients	patient	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	12	12	CD	CD	_	34	nummod	_	_
33	healthy	healthy	JJ	JJ	_	34	amod	_	_
34	controls	control	NNS	NNS	_	30	conj	_	_
35	.	.	.	.	_	23	punct	_	_

1	GR	gr	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	differ	differ	VB	VB	_	0	root	_	_
7	between	between	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	controls	control	NNS	NNS	_	8	conj	_	_
11	or	or	CC	CC	_	8	cc	_	_
12	between	between	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	8	conj	_	_
14	subdivided	subdivide	VBN	VBN	_	13	acl	_	_
15	according	accord	VBG	VBG	_	17	case	_	_
16	to	to	TO	TO	_	15	mwe	_	_
17	diagnosis	diagnosis	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	associated	associate	VBN	VBN	_	21	amod	_	_
20	clinical	clinical	JJ	JJ	_	21	amod	_	_
21	features	feature	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	abnormalities	abnormality	NNS	NNS	_	15	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	HPA	hpa	NN	NN	_	10	compound	_	_
10	system	system	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	AD	ad	NN	NN	_	10	nmod	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	related	related	JJ	JJ	_	3	ccomp	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	GR	gr	NN	NN	_	19	compound	_	_
19	deficiency	deficiency	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Kappa	kappa	NN	NN	_	4	compound	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	constitutively	constitutively	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	15	case	_	_
9	an	a	DT	DT	_	15	det	_	_
10	IL-2	il-2	NN	NN	_	15	compound	_	_
11	autocrine	autocrine	NN	NN	_	15	compound	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	IL-2	il-2	NN	NN	_	7	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	the	the	DT	DT	_	6	det	_	_
5	IL-2-R	il-2-r	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	2	conj	_	_
7	genes	gene	NNS	NNS	_	10	nsubj	_	_
8	are	be	VBP	VBP	_	10	aux	_	_
9	both	both	DT	DT	_	10	dep	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	transiently	transiently	RB	RB	_	10	advmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	after	after	IN	IN	_	20	case	_	_
17	Ag	ag	NN	NN	_	20	compound	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	mitogen	mitogen	NN	NN	_	17	conj	_	_
20	activation	activation	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	13	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	IARC	iarc	NN	NN	_	8	appos	_	_
11	301	301	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	8	punct	_	_
13	expresses	express	VBZ	VBZ	_	0	root	_	_
14	these	these	DT	DT	_	16	det	_	_
15	two	two	CD	CD	_	16	nummod	_	_
16	genes	gene	NNS	NNS	_	13	dobj	_	_
17	constitutively	constitutively	RB	RB	_	13	advmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	we	we	PRP	PRP	_	22	nsubj	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	previously	previously	RB	RB	_	22	advmod	_	_
22	demonstrated	demonstrate	VBN	VBN	_	13	conj	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	growth	growth	NN	NN	_	26	nsubj	_	_
26	depends	depend	VBZ	VBZ	_	22	ccomp	_	_
27	on	on	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	autocrine	autocrine	JJ	JJ	_	30	amod	_	_
30	production	production	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	this	this	DT	DT	_	36	det	_	_
33	T	t	NN	NN	_	36	compound	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	growth	growth	NN	NN	_	36	compound	_	_
36	factor	factor	NN	NN	_	30	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	high	high	JJ	JJ	_	40	amod	_	_
39	affinity	affinity	NN	NN	_	40	compound	_	_
40	IL-2R	il-2r	NN	NN	_	36	conj	_	_
41	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	dissect	dissect	VB	VB	_	27	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	unusual	unusual	JJ	JJ	_	10	amod	_	_
9	persistent	persistent	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	IL-2	il-2	NN	NN	_	17	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IL-2-R	il-2-r	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	13	conj	_	_
17	genes	gene	NNS	NNS	_	10	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	these	these	DT	DT	_	23	det	_	_
20	IARC	iarc	NN	NN	_	23	compound	_	_
21	301	301	CD	CD	_	23	nummod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	27	punct	_	_
25	we	we	PRP	PRP	_	27	nsubj	_	_
26	have	have	VBP	VBP	_	27	aux	_	_
27	analyzed	analyze	VBN	VBN	_	0	root	_	_
28	the	the	DT	DT	_	29	det	_	_
29	interactions	interaction	NNS	NNS	_	27	dobj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	constitutively	constitutively	RB	RB	_	32	advmod	_	_
32	expressed	express	VBN	VBN	_	34	amod	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	proteins	protein	NNS	NNS	_	29	nmod	_	_
35	with	with	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	5'	5'	JJ	JJ	_	39	amod	_	_
38	flanking	flanking	JJ	JJ	_	39	amod	_	_
39	regions	region	NNS	NNS	_	29	nmod	_	_
40	of	of	IN	IN	_	46	case	_	_
41	the	the	DT	DT	_	46	det	_	_
42	IL-2	il-2	NN	NN	_	46	compound	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	IL-2-R	il-2-r	NN	NN	_	45	compound	_	_
45	alpha	alpha	NN	NN	_	42	conj	_	_
46	genes	gene	NNS	NNS	_	39	nmod	_	_
47	using	use	VBG	VBG	_	27	xcomp	_	_
48	both	both	DT	DT	_	51	cc:preconj	_	_
49	DNase	dnase	NN	NN	_	51	compound	_	_
50	I	i	CD	CD	_	51	nummod	_	_
51	footprinting	footprinting	NN	NN	_	55	compound	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	gel	gel	NN	NN	_	54	compound	_	_
54	retardation	retardation	NN	NN	_	51	conj	_	_
55	techniques	technique	NNS	NNS	_	47	dobj	_	_
56	.	.	.	.	_	27	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	36	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	region	region	NN	NN	_	36	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	both	both	DT	DT	_	9	det	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	-276	-276	CD	CD	_	6	dep	_	_
12	to	to	TO	TO	_	11	dep	_	_
13	-250	-250	CD	CD	_	11	dep	_	_
14	for	for	IN	IN	_	16	case	_	_
15	IL-2-R	il-2-r	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	-203	-203	CD	CD	_	11	conj	_	_
19	to	to	TO	TO	_	18	dep	_	_
20	-183	-183	CD	CD	_	18	dep	_	_
21	for	for	IN	IN	_	22	case	_	_
22	IL-2	il-2	NN	NN	_	18	nmod	_	_
23	)	)	-RRB-	-RRB-	_	11	punct	_	_
24	,	,	,	,	_	6	punct	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	corresponds	correspond	VBZ	VBZ	_	6	acl:relcl	_	_
27	to	to	TO	TO	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	kappa	kappa	NN	NN	_	32	compound	_	_
30	B	b	NN	NN	_	32	compound	_	_
31	enhancer	enhancer	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	26	nmod	_	_
33	,	,	,	,	_	6	punct	_	_
34	is	be	VBZ	VBZ	_	36	auxpass	_	_
35	specifically	specifically	RB	RB	_	36	advmod	_	_
36	protected	protect	VBN	VBN	_	3	ccomp	_	_
37	by	by	IN	IN	_	39	case	_	_
38	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
39	proteins	protein	NNS	NNS	_	36	nmod	_	_
40	from	from	IN	IN	_	41	case	_	_
41	IARC	iarc	NN	NN	_	39	nmod	_	_
42	301	301	CD	CD	_	41	nummod	_	_
43	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	agreement	agreement	NN	NN	_	5	dep	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	finding	finding	NN	NN	_	15	nmod	_	_
6	,	,	,	,	_	15	punct	_	_
7	both	both	CC	CC	_	13	cc:preconj	_	_
8	the	the	DT	DT	_	13	det	_	_
9	IL-2	il-2	NN	NN	_	13	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-2-R	il-2-r	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	9	conj	_	_
13	promoters	promoter	NNS	NNS	_	15	nsubj	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	active	active	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	transient	transient	JJ	JJ	_	19	amod	_	_
18	transfection	transfection	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	IARC	iarc	NN	NN	_	23	compound	_	_
22	301	301	CD	CD	_	23	nummod	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	mutation	mutation	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	4	nmod	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	attenuated	attenuate	VBN	VBN	_	14	amod	_	_
14	activities	activity	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	both	both	DT	DT	_	17	det	_	_
17	promoters	promoter	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	proteins	protein	NNS	NNS	_	16	nsubjpass	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	7	det	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	2	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	2	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	KBF1	kbf1	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	2	punct	_	_
14	are	be	VBP	VBP	_	16	auxpass	_	_
15	constitutively	constitutively	RB	RB	_	16	advmod	_	_
16	expressed	express	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	20	case	_	_
18	IARC	iarc	NN	NN	_	20	compound	_	_
19	301	301	CD	CD	_	20	nummod	_	_
20	nuclei	nucleus	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	induced	induce	VBN	VBN	_	16	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	PMA	pma	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	PHA	pha	NN	NN	_	24	conj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	Jurkat	jurkat	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	bind	bind	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	motifs	motif	NNS	NNS	_	2	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	relative	relative	JJ	JJ	_	11	amod	_	_
11	affinities	affinity	NNS	NNS	_	7	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	reflect	reflect	VB	VB	_	7	acl:relcl	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	different	different	JJ	JJ	_	17	amod	_	_
17	contribution	contribution	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	various	various	JJ	JJ	_	23	amod	_	_
23	promoters	promoter	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	domains	domain	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	murine	murine	JJ	JJ	_	9	amod	_	_
7	Thy-1	thy-1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Thy-1	thy-1	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	nsubj	_	_
5	resembles	resemble	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	``	``	``	``	_	9	punct	_	_
8	housekeeping	housekeeping	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	5	xcomp	_	_
10	in	in	IN	IN	_	14	mark	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	it	it	PRP	PRP	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	located	located	JJ	JJ	_	5	advcl	_	_
15	within	within	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	methylation-free	methylation-free	JJ	JJ	_	18	amod	_	_
18	island	island	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	lacks	lack	VBZ	VBZ	_	14	conj	_	_
21	a	a	DT	DT	_	24	det	_	_
22	canonical	canonical	JJ	JJ	_	24	amod	_	_
23	TATA	tata	NN	NN	_	24	compound	_	_
24	box	box	NN	NN	_	20	dobj	_	_
25	,	,	,	,	_	14	punct	_	_
26	and	and	CC	CC	_	14	cc	_	_
27	displays	display	VBZ	VBZ	_	14	conj	_	_
28	heterogeneity	heterogeneity	NN	NN	_	27	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	5'-end	5'-end	JJ	JJ	_	32	amod	_	_
32	termini	terminus	NNS	NNS	_	27	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	mRNA	mrna	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	transgenic	transgenic	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	this	this	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	12	nsubj	_	_
10	does	do	VBZ	VBZ	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	confer	confer	VB	VB	_	6	ccomp	_	_
13	any	any	DT	DT	_	15	det	_	_
14	tissue	tissue	NN	NN	_	15	compound	_	_
15	specificity	specificity	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	active	active	JJ	JJ	_	12	conj	_	_
19	only	only	RB	RB	_	23	advmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	position-dependent	position-dependent	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	can	can	MD	MD	_	5	aux	_	_
3	only	only	RB	RB	_	5	advmod	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	tissue-specific	tissue-specific	JJ	JJ	_	9	amod	_	_
9	manner	manner	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	elements	element	NNS	NNS	_	5	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	lie	lie	VBP	VBP	_	11	acl:relcl	_	_
14	downstream	downstream	RB	RB	_	13	xcomp	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	initiation	initiation	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	domains	domain	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	minimal	minimal	JJ	JJ	_	11	amod	_	_
10	Thy-1	thy-1	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	show	show	VB	VB	_	3	conj	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	dominant	dominant	JJ	JJ	_	18	amod	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	19	nsubj	_	_
19	consist	consist	VBP	VBP	_	13	ccomp	_	_
20	of	of	IN	IN	_	23	case	_	_
21	multiple	multiple	JJ	JJ	_	23	amod	_	_
22	binding	bind	VBG	VBG	_	23	amod	_	_
23	sites	site	NNS	NNS	_	19	nmod	_	_
24	for	for	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	Sp1	sp1	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	an	a	DT	DT	_	33	det	_	_
31	inverted	inverted	JJ	JJ	_	33	amod	_	_
32	CCAAT	ccaat	NN	NN	_	33	compound	_	_
33	box	box	NN	NN	_	28	conj	_	_
34	,	,	,	,	_	28	punct	_	_
35	and	and	CC	CC	_	28	cc	_	_
36	sequences	sequence	VBZ	VBZ	_	28	conj	_	_
37	proximal	proximal	JJ	JJ	_	36	amod	_	_
38	to	to	TO	TO	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	transcription	transcription	NN	NN	_	42	compound	_	_
41	start	start	NN	NN	_	42	compound	_	_
42	site	site	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	DNase	dnase	NN	NN	_	8	nsubj	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	gel	gel	NN	NN	_	7	compound	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	1	conj	_	_
8	show	show	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	binding	binding	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	number	number	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	elements	element	NNS	NNS	_	10	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	22	case	_	_
22	Sp1	sp1	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	CP1	cp1	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	structure	structure	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	6	nmod	_	_
10	only	only	RB	RB	_	11	advmod	_	_
11	permits	permit	VBZ	VBZ	_	3	ccomp	_	_
12	productive	productive	JJ	JJ	_	13	amod	_	_
13	interactions	interaction	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	13	nmod	_	_
19	Sp1	sp1	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	CP1	cp1	NN	NN	_	19	conj	_	_
22	with	with	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	basal	basal	JJ	JJ	_	26	amod	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	machinery	machinery	NN	NN	_	13	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	dep	_	_
29	presence	presence	NN	NN	_	32	dep	_	_
30	of	of	IN	IN	_	32	case	_	_
31	enhancer	enhancer	NN	NN	_	32	compound	_	_
32	sequences	sequence	NNS	NNS	_	11	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Estrogen	estrogen	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	concentration	concentration	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	social	social	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	3	conj	_	_
7	as	as	IN	IN	_	8	case	_	_
8	predictors	predictor	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	natural	natural	JJ	JJ	_	13	amod	_	_
11	killer	killer	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	early-stage	early-stage	JJ	JJ	_	18	amod	_	_
16	breast	breast	NN	NN	_	18	compound	_	_
17	cancer	cancer	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Confirmation	confirmation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	1	nmod	_	_
5	.	.	.	.	_	1	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ours	ours	PRP	PRP	_	2	nmod	_	_
5	has	have	VBZ	VBZ	_	6	aux	_	_
6	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	31	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	amount	amount	NN	NN	_	31	nsubjpass	_	_
11	of	of	IN	IN	_	18	case	_	_
12	natural	natural	JJ	JJ	_	13	amod	_	_
13	killer	killer	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NK	nk	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	activity	activity	NN	NN	_	18	compound	_	_
18	variance	variance	NN	NN	_	10	nmod	_	_
19	after	after	IN	IN	_	20	case	_	_
20	surgery	surgery	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	stage	stage	NN	NN	_	20	nmod	_	_
23	I	i	CD	CD	_	22	dep	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	II	ii	CD	CD	_	22	conj	_	_
26	breast	breast	NN	NN	_	28	compound	_	_
27	cancer	cancer	NN	NN	_	28	compound	_	_
28	patients	patient	NNS	NNS	_	22	dep	_	_
29	could	could	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	accounted	account	VBN	VBN	_	6	ccomp	_	_
32	for	for	IN	IN	_	33	case	_	_
33	by	by	IN	IN	_	31	nmod	_	_
34	both	both	CC	CC	_	33	cc:preconj	_	_
35	the	the	DT	DT	_	41	det	_	_
36	estrogen	estrogen	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	41	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	ER	er	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	status	status	NN	NN	_	33	conj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	tumor	tumor	NN	NN	_	41	nmod	_	_
45	and	and	CC	CC	_	33	cc	_	_
46	by	by	IN	IN	_	48	case	_	_
47	social	social	JJ	JJ	_	48	amod	_	_
48	factors	factor	NNS	NNS	_	33	conj	_	_
49	,	,	,	,	_	48	punct	_	_
50	namely	namely	RB	RB	_	48	advmod	_	_
51	,	,	,	,	_	48	punct	_	_
52	perceived	perceive	VBN	VBN	_	54	amod	_	_
53	social	social	JJ	JJ	_	54	amod	_	_
54	support	support	NN	NN	_	48	appos	_	_
55	and	and	CC	CC	_	54	cc	_	_
56	seeking	seek	VBG	VBG	_	54	conj	_	_
57	social	social	JJ	JJ	_	58	amod	_	_
58	support	support	NN	NN	_	56	dobj	_	_
59	as	as	IN	IN	_	63	case	_	_
60	a	a	DT	DT	_	63	det	_	_
61	general	general	JJ	JJ	_	63	amod	_	_
62	coping	coping	NN	NN	_	63	compound	_	_
63	strategy	strategy	NN	NN	_	33	nmod	_	_
64	.	.	.	.	_	6	punct	_	_

1	As	as	IN	IN	_	16	dep	_	_
2	considerable	considerable	JJ	JJ	_	3	amod	_	_
3	evidence	evidence	NN	NN	_	16	dep	_	_
4	has	have	VBZ	VBZ	_	5	aux	_	_
5	accumulated	accumulate	VBN	VBN	_	16	dep	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	social	social	JJ	JJ	_	8	amod	_	_
8	support	support	NN	NN	_	16	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	animal	animal	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	human	human	JJ	JJ	_	11	conj	_	_
14	populations	population	NNS	NNS	_	11	dep	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	have	have	VB	VB	_	21	advcl	_	_
17	survival	survival	NN	NN	_	18	compound	_	_
18	value	value	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	sought	seek	VBD	VBD	_	0	root	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	test	test	VB	VB	_	21	xcomp	_	_
24	the	the	DT	DT	_	25	det	_	_
25	reliability	reliability	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	this	this	DT	DT	_	29	det	_	_
28	regression	regression	NN	NN	_	29	compound	_	_
29	model	model	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	using	use	VBG	VBG	_	23	advcl	_	_
32	coping	coping	NN	NN	_	31	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	perceived	perceive	VBN	VBN	_	37	amod	_	_
35	support	support	NN	NN	_	37	compound	_	_
36	factor	factor	NN	NN	_	37	compound	_	_
37	values	value	NNS	NNS	_	32	conj	_	_
38	obtained	obtain	VBN	VBN	_	32	acl	_	_
39	at	at	IN	IN	_	41	case	_	_
40	3	3	CD	CD	_	41	nummod	_	_
41	months	month	NNS	NNS	_	38	nmod	_	_
42	after	after	IN	IN	_	43	case	_	_
43	surgery	surgery	NN	NN	_	41	nmod	_	_
44	to	to	TO	TO	_	45	mark	_	_
45	account	account	VB	VB	_	31	advcl	_	_
46	for	for	IN	IN	_	50	case	_	_
47	concurrent	concurrent	JJ	JJ	_	50	amod	_	_
48	follow-up	follow-up	JJ	JJ	_	47	dep	_	_
49	NK	nk	NN	NN	_	50	compound	_	_
50	activity	activity	NN	NN	_	45	nmod	_	_
51	in	in	IN	IN	_	55	case	_	_
52	this	this	DT	DT	_	55	det	_	_
53	serially	serially	RB	RB	_	54	advmod	_	_
54	assessed	assess	VBN	VBN	_	55	amod	_	_
55	group	group	NN	NN	_	50	nmod	_	_
56	of	of	IN	IN	_	57	case	_	_
57	patients	patient	NNS	NNS	_	55	nmod	_	_
58	.	.	.	.	_	21	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	most	most	RBS	RBS	_	7	advmod	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	variable	variable	NN	NN	_	17	nsubj	_	_
9	predicting	predict	VBG	VBG	_	8	acl	_	_
10	NK	nk	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	at	at	IN	IN	_	13	case	_	_
13	follow-up	follow-up	NN	NN	_	9	nmod	_	_
14	was	be	VBD	VBD	_	17	cop	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	ER	er	NN	NN	_	17	compound	_	_
17	concentration	concentration	NN	NN	_	3	ccomp	_	_
18	,	,	,	,	_	17	punct	_	_
19	with	with	IN	IN	_	23	mark	_	_
20	higher	higher	JJR	JJR	_	22	amod	_	_
21	NK	nk	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	23	nsubj	_	_
23	associated	associate	VBN	VBN	_	17	advcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	ER-	er-	JJ	JJ	_	26	amod	_	_
26	status	status	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	22	nmod	_	_
3	,	,	,	,	_	22	punct	_	_
4	seeking	seek	VBG	VBG	_	22	dep	_	_
5	social	social	JJ	JJ	_	6	amod	_	_
6	support	support	NN	NN	_	4	dobj	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	coping	coping	NN	NN	_	10	compound	_	_
10	strategy	strategy	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	as	as	RB	RB	_	4	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	the	the	DT	DT	_	17	det	_	_
16	perceived	perceive	VBN	VBN	_	17	amod	_	_
17	quality	quality	NN	NN	_	4	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	support	support	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	4	punct	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	entered	enter	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	model	model	NN	NN	_	22	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	account	account	VB	VB	_	24	acl	_	_
27	for	for	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	significant	significant	JJ	JJ	_	30	amod	_	_
30	amount	amount	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	NK	nk	NN	NN	_	34	compound	_	_
33	activity	activity	NN	NN	_	34	compound	_	_
34	variance	variance	NN	NN	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	multivariate	multivariate	JJ	JJ	_	37	amod	_	_
37	F	f	NN	NN	_	22	dep	_	_
38	=	=	JJ	JJ	_	37	amod	_	_
39	5.25	5.25	CD	CD	_	38	dep	_	_
40	,	,	,	,	_	37	punct	_	_
41	p	p	NN	NN	_	37	appos	_	_
42	less	less	JJR	JJR	_	41	amod	_	_
43	than	than	IN	IN	_	44	case	_	_
44	0.001	0.001	CD	CD	_	42	nmod	_	_
45	)	)	-RRB-	-RRB-	_	37	punct	_	_
46	.	.	.	.	_	22	punct	_	_

1	If	if	IN	IN	_	11	dep	_	_
2	,	,	,	,	_	11	punct	_	_
3	as	as	IN	IN	_	6	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	literature	literature	NN	NN	_	6	nsubj	_	_
6	suggests	suggest	VBZ	VBZ	_	11	dep	_	_
7	,	,	,	,	_	11	punct	_	_
8	NK	nk	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	relevant	relevant	JJ	JJ	_	27	dep	_	_
12	to	to	TO	TO	_	15	case	_	_
13	breast	breast	NN	NN	_	15	compound	_	_
14	cancer	cancer	NN	NN	_	15	compound	_	_
15	control	control	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	since	since	IN	IN	_	21	mark	_	_
19	ER-	er-	JJ	JJ	_	20	amod	_	_
20	tumors	tumor	NNS	NNS	_	21	nsubj	_	_
21	have	have	VBP	VBP	_	11	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	worse	worse	JJR	JJR	_	24	amod	_	_
24	prognosis	prognosis	NN	NN	_	21	dobj	_	_
25	,	,	,	,	_	27	punct	_	_
26	we	we	PRP	PRP	_	27	nsubj	_	_
27	suggest	suggest	VBP	VBP	_	0	root	_	_
28	here	here	RB	RB	_	27	advmod	_	_
29	that	that	IN	IN	_	34	mark	_	_
30	perhaps	perhaps	RB	RB	_	34	advmod	_	_
31	such	such	JJ	JJ	_	32	amod	_	_
32	tumors	tumor	NNS	NNS	_	34	nsubj	_	_
33	are	be	VBP	VBP	_	34	cop	_	_
34	resistant	resistant	JJ	JJ	_	27	ccomp	_	_
35	to	to	TO	TO	_	36	case	_	_
36	control	control	NN	NN	_	34	nmod	_	_
37	by	by	IN	IN	_	39	case	_	_
38	NK	nk	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	because	because	IN	IN	_	42	mark	_	_
41	they	they	PRP	PRP	_	42	nsubj	_	_
42	lack	lack	VBP	VBP	_	34	advcl	_	_
43	the	the	DT	DT	_	44	det	_	_
44	ability	ability	NN	NN	_	42	dobj	_	_
45	to	to	TO	TO	_	46	mark	_	_
46	attract	attract	VB	VB	_	44	acl	_	_
47	an	a	DT	DT	_	48	det	_	_
48	accumulation	accumulation	NN	NN	_	46	dobj	_	_
49	of	of	IN	IN	_	51	case	_	_
50	effector	effector	NN	NN	_	51	compound	_	_
51	cells	cell	NNS	NNS	_	48	nmod	_	_
52	to	to	TO	TO	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	tumor	tumor	NN	NN	_	55	compound	_	_
55	site	site	NN	NN	_	46	nmod	_	_
56	,	,	,	,	_	42	punct	_	_
57	or	or	CC	CC	_	42	cc	_	_
58	because	because	IN	IN	_	67	mark	_	_
59	blocking	blocking	NN	NN	_	60	compound	_	_
60	factors	factor	NNS	NNS	_	67	nsubj	_	_
61	at	at	IN	IN	_	63	case	_	_
62	the	the	DT	DT	_	63	det	_	_
63	site	site	NN	NN	_	60	nmod	_	_
64	of	of	IN	IN	_	66	case	_	_
65	the	the	DT	DT	_	66	det	_	_
66	tumor	tumor	NN	NN	_	63	nmod	_	_
67	prevent	prevent	VBP	VBP	_	42	conj	_	_
68	local	local	JJ	JJ	_	70	amod	_	_
69	tumor	tumor	NN	NN	_	70	compound	_	_
70	control	control	NN	NN	_	67	dobj	_	_
71	at	at	IN	IN	_	73	case	_	_
72	the	the	DT	DT	_	73	det	_	_
73	site	site	NN	NN	_	67	nmod	_	_
74	of	of	IN	IN	_	75	case	_	_
75	action	action	NN	NN	_	73	nmod	_	_
76	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	8	nsubj	_	_
3	related	related	JJ	JJ	_	2	amod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	social	social	JJ	JJ	_	6	amod	_	_
6	support	support	NN	NN	_	3	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	replicates	replicate	VBZ	VBZ	_	0	root	_	_
9	results	result	NNS	NNS	_	8	dobj	_	_
10	from	from	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	independent	independent	JJ	JJ	_	13	amod	_	_
13	sample	sample	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	breast	breast	NN	NN	_	17	compound	_	_
16	cancer	cancer	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	23	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	taken	take	VBN	VBN	_	23	dep	_	_
5	together	together	RB	RB	_	4	advmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	evidence	evidence	NN	NN	_	4	nmod	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	this	this	DT	DT	_	12	det	_	_
11	social	social	JJ	JJ	_	12	amod	_	_
12	variable	variable	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	8	ccomp	_	_
15	with	with	IN	IN	_	17	case	_	_
16	longer	longer	JJR	JJR	_	17	amod	_	_
17	survival	survival	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	breast	breast	NN	NN	_	21	compound	_	_
20	cancer	cancer	NN	NN	_	21	compound	_	_
21	populations	population	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	23	punct	_	_
23	underscores	underscore	VBZ	VBZ	_	0	root	_	_
24	the	the	DT	DT	_	26	det	_	_
25	potential	potential	JJ	JJ	_	26	amod	_	_
26	importance	importance	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	this	this	DT	DT	_	31	det	_	_
29	social	social	JJ	JJ	_	31	amod	_	_
30	support	support	NN	NN	_	31	compound	_	_
31	variable	variable	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	23	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	one	one	CD	CD	_	8	nummod	_	_
6	possible	possible	JJ	JJ	_	8	amod	_	_
7	immunological	immunological	JJ	JJ	_	6	dep	_	_
8	variable	variable	NN	NN	_	4	dobj	_	_
9	involved	involved	JJ	JJ	_	4	dep	_	_
10	,	,	,	,	_	4	punct	_	_
11	with	with	IN	IN	_	14	case	_	_
12	potential	potential	JJ	JJ	_	14	amod	_	_
13	clinical	clinical	JJ	JJ	_	12	dep	_	_
14	significance	significance	NN	NN	_	4	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	for	for	IN	IN	_	19	case	_	_
17	this	this	DT	DT	_	19	det	_	_
18	patient	patient	NN	NN	_	19	compound	_	_
19	population	population	NN	NN	_	4	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	inducible	inducible	JJ	JJ	_	3	conj	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	enhancement	enhancement	NN	NN	_	1	nmod	_	_
8	mediated	mediate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	12	case	_	_
10	kappa	kappa	NN	NN	_	11	nmod:npmod	_	_
11	B-related	b-related	JJ	JJ	_	12	amod	_	_
12	sequences	sequence	NNS	NNS	_	8	nmod	_	_
13	:	:	:	:	_	1	punct	_	_
14	modulation	modulation	NN	NN	_	1	dep	_	_
15	of	of	IN	IN	_	16	case	_	_
16	activity	activity	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	by	by	IN	IN	_	28	case	_	_
21	human	human	JJ	JJ	_	28	amod	_	_
22	T-cell	t-cell	NN	NN	_	28	compound	_	_
23	leukemia	leukemia	NN	NN	_	28	compound	_	_
24	virus	virus	NN	NN	_	28	compound	_	_
25	type	type	NN	NN	_	28	compound	_	_
26	I	i	CD	CD	_	28	nummod	_	_
27	tax	tax	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	14	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GGGACTTTCC	gggactttcc	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	binds	bind	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	factor	factor	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	appos	_	_
14	,	,	,	,	_	10	punct	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	constitutively	constitutively	RB	RB	_	18	advmod	_	_
18	found	find	VBN	VBN	_	10	acl:relcl	_	_
19	in	in	IN	IN	_	25	case	_	_
20	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
21	functional	functional	JJ	JJ	_	25	amod	_	_
22	,	,	,	,	_	21	punct	_	_
23	DNA	dna	NN	NN	_	24	dep	_	_
24	binding	binding	NN	NN	_	21	dep	_	_
25	form	form	NN	NN	_	18	nmod	_	_
26	only	only	RB	RB	_	29	advmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	10	nsubjpass	_	_
3	with	with	IN	IN	_	7	case	_	_
4	apparently	apparently	RB	RB	_	5	advmod	_	_
5	indistinguishable	indistinguishable	JJ	JJ	_	7	amod	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	specificity	specificity	NN	NN	_	2	nmod	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	many	many	JJ	JJ	_	15	amod	_	_
13	other	other	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	types	type	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	where	where	WRB	WRB	_	20	advmod	_	_
18	it	it	PRP	PRP	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	used	use	VBN	VBN	_	15	acl:relcl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	regulate	regulate	VB	VB	_	20	xcomp	_	_
23	inducible	inducible	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	10	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	example	example	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	kappa	kappa	NN	NN	_	5	nmod:npmod	_	_
5	B-related	b-related	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	9	nsubjpass	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	important	important	JJ	JJ	_	9	xcomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	18	advmod	_	_
18	few	few	JJ	JJ	_	20	nummod	_	_
19	inducible	inducible	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	such	such	JJ	JJ	_	29	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	the	the	DT	DT	_	29	det	_	_
25	interleukin	interleukin	NN	NN	_	29	compound	_	_
26	2	2	CD	CD	_	29	nummod	_	_
27	receptor	receptor	NN	NN	_	29	compound	_	_
28	alpha-chain	alpha-chain	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	20	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	beta-interferon	beta-interferon	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	conj	_	_
34	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	8	nsubj	_	_
5	are	be	VBP	VBP	_	8	cop	_	_
6	not	not	RB	RB	_	8	neg	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	active	active	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	other	other	JJ	JJ	_	17	amod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	mechanisms	mechanism	NNS	NNS	_	19	nsubj	_	_
18	must	must	MD	MD	_	19	aux	_	_
19	play	play	VB	VB	_	13	ccomp	_	_
20	a	a	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	determining	determine	VBG	VBG	_	19	advcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	patterns	pattern	NNS	NNS	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	expression	expression	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	9	det	_	_
5	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	inducible	inducible	JJ	JJ	_	5	conj	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	3	dobj	_	_
10	mediated	mediate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	16	case	_	_
12	five	five	CD	CD	_	16	nummod	_	_
13	kappa	kappa	NN	NN	_	14	nmod:npmod	_	_
14	B-related	b-related	JJ	JJ	_	16	amod	_	_
15	sequence	sequence	NN	NN	_	16	compound	_	_
16	elements	element	NNS	NNS	_	10	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	different	different	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	types	type	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	in	in	IN	IN	_	7	case	_	_
5	S194	s194	NN	NN	_	7	compound	_	_
6	plasma	plasma	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	13	nmod	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activity	activity	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	each	each	DT	DT	_	12	det	_	_
12	element	element	NN	NN	_	9	nmod	_	_
13	correlates	correlate	VBZ	VBZ	_	2	ccomp	_	_
14	well	well	RB	RB	_	13	advmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	relative	relative	JJ	JJ	_	18	amod	_	_
18	affinity	affinity	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	B-cell-derived	b-cell-derived	JJ	JJ	_	22	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	18	nmod	_	_
23	for	for	IN	IN	_	25	case	_	_
24	that	that	DT	DT	_	25	det	_	_
25	element	element	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	leads	lead	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	7	case	_	_
4	significantly	significantly	RB	RB	_	5	advmod	_	_
5	lower	lower	RBR	RBR	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	enhancement	enhancement	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	sites	site	NNS	NNS	_	7	nmod	_	_
10	derived	derive	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	19	case	_	_
12	the	the	DT	DT	_	19	det	_	_
13	interleukin	interleukin	NN	NN	_	15	compound	_	_
14	2	2	CD	CD	_	15	nummod	_	_
15	receptor	receptor	NN	NN	_	19	compound	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	15	conj	_	_
19	genes	gene	NNS	NNS	_	10	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	S194	s194	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	in	in	IN	IN	_	9	case	_	_
4	either	either	CC	CC	_	9	cc:preconj	_	_
5	EL-4	el-4	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	cells	cell	NNS	NNS	_	20	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	S194	s194	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	20	punct	_	_
14	both	both	DT	DT	_	16	det	_	_
15	lower-affinity	lower-affinity	JJ	JJ	_	16	amod	_	_
16	sites	site	NNS	NNS	_	20	nsubjpass	_	_
17	can	can	MD	MD	_	20	aux	_	_
18	be	be	VB	VB	_	20	auxpass	_	_
19	significantly	significantly	RB	RB	_	20	advmod	_	_
20	induced	induce	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	tax	tax	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	product	product	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	human	human	JJ	JJ	_	31	amod	_	_
28	T-cell	t-cell	NN	NN	_	31	compound	_	_
29	leukemia	leukemia	NN	NN	_	31	compound	_	_
30	virus	virus	NN	NN	_	31	compound	_	_
31	type	type	NN	NN	_	25	nmod	_	_
32	I	i	CD	CD	_	31	nummod	_	_
33	,	,	,	,	_	20	punct	_	_
34	showing	show	VBG	VBG	_	20	xcomp	_	_
35	that	that	IN	IN	_	41	mark	_	_
36	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	41	nsubjpass	_	_
39	can	can	MD	MD	_	41	aux	_	_
40	be	be	VB	VB	_	41	auxpass	_	_
41	modulated	modulate	VBN	VBN	_	34	ccomp	_	_
42	even	even	RB	RB	_	46	advmod	_	_
43	in	in	IN	IN	_	46	case	_	_
44	a	a	DT	DT	_	46	det	_	_
45	B-cell	b-cell	NN	NN	_	46	compound	_	_
46	line	line	NN	NN	_	41	nmod	_	_
47	that	that	WDT	WDT	_	49	nsubj	_	_
48	constitutively	constitutively	RB	RB	_	49	advmod	_	_
49	expresses	express	VBZ	VBZ	_	46	acl:relcl	_	_
50	this	this	DT	DT	_	51	det	_	_
51	factor	factor	NN	NN	_	49	dobj	_	_
52	.	.	.	.	_	20	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	rel-related	rel-related	JJ	JJ	_	6	amod	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	cDNA	cdna	NN	NN	_	1	nmod	_	_
7	that	that	WDT	WDT	_	9	nsubj	_	_
8	potentially	potentially	RB	RB	_	9	advmod	_	_
9	encodes	encode	VBZ	VBZ	_	6	acl:relcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	65-kD	65-kd	JJ	JJ	_	12	amod	_	_
12	subunit	subunit	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	nmod	_	_
16	-LSB-	-lsb-	-LRB-	-LRB-	_	19	punct	_	_
17	published	publish	VBN	VBN	_	18	amod	_	_
18	erratum	erratum	NN	NN	_	19	nsubj	_	_
19	appears	appear	VBZ	VBZ	_	1	dep	_	_
20	in	in	IN	IN	_	23	case	_	_
21	Science	Science	NNP	NNP	_	23	compound	_	_
22	1991	1991	CD	CD	_	23	nummod	_	_
23	Oct	Oct	NNP	NNP	_	19	nmod	_	_
24	4	4	CD	CD	_	23	nummod	_	_
25	;	;	:	:	_	23	punct	_	_
26	254	254	CD	CD	_	23	nummod	_	_
27	(	(	-LRB-	-LRB-	_	23	punct	_	_
28	5028	5028	CD	CD	_	23	nummod	_	_
29	)	)	-RRB-	-RRB-	_	23	punct	_	_
30	:	:	:	:	_	23	punct	_	_
31	11	11	CD	CD	_	23	nummod	_	_
32	-RSB-	-rsb-	-RRB-	-RRB-	_	19	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	probe	probe	NN	NN	_	29	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	spanned	span	VBD	VBD	_	3	acl:relcl	_	_
6	a	a	DT	DT	_	7	det	_	_
7	domain	domain	NN	NN	_	5	dobj	_	_
8	conserved	conserve	VBN	VBN	_	7	acl	_	_
9	among	among	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	proto-oncogene	proto-oncogene	NN	NN	_	12	compound	_	_
12	c-rel	c-rel	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	17	det	_	_
15	Drosophila	drosophila	NN	NN	_	17	compound	_	_
16	morphogen	morphogen	NN	NN	_	17	compound	_	_
17	dorsal	dorsal	NN	NN	_	12	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	the	the	DT	DT	_	24	det	_	_
21	p50	p50	NN	NN	_	24	compound	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	subunit	subunit	NN	NN	_	12	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	generated	generate	VBN	VBN	_	0	root	_	_
30	from	from	IN	IN	_	35	case	_	_
31	Jurkat	jurkat	NN	NN	_	35	compound	_	_
32	T	t	NN	NN	_	35	compound	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	complementary	complementary	JJ	JJ	_	35	amod	_	_
35	DNA	dna	NN	NN	_	29	nmod	_	_
36	with	with	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	polymerase	polymerase	NN	NN	_	40	compound	_	_
39	chain	chain	NN	NN	_	40	compound	_	_
40	reaction	reaction	NN	NN	_	35	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	PCR	pcr	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	degenerate	degenerate	JJ	JJ	_	46	amod	_	_
46	oligonucleotides	oligonucleotide	NNS	NNS	_	40	conj	_	_
47	.	.	.	.	_	29	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	probe	probe	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	identify	identify	VB	VB	_	4	xcomp	_	_
7	a	a	DT	DT	_	10	det	_	_
8	rel-related	rel-related	JJ	JJ	_	10	amod	_	_
9	complementary	complementary	JJ	JJ	_	10	amod	_	_
10	DNA	dna	NN	NN	_	6	dobj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	hybridized	hybridize	VBD	VBD	_	10	acl:relcl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	2.6-kilobase	2.6-kilobase	JJ	JJ	_	17	amod	_	_
16	messenger	messenger	NN	NN	_	17	compound	_	_
17	RNA	rna	NN	NN	_	12	nmod	_	_
18	present	present	JJ	JJ	_	17	amod	_	_
19	in	in	IN	IN	_	24	case	_	_
20	human	human	JJ	JJ	_	24	amod	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	B	b	NN	NN	_	21	conj	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	translation	translation	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	complementary	complementary	JJ	JJ	_	9	amod	_	_
9	DNA	dna	NN	NN	_	3	nmod	_	_
10	resulted	result	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	synthesis	synthesis	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	an	a	DT	DT	_	21	det	_	_
19	apparent	apparent	JJ	JJ	_	21	amod	_	_
20	molecular	molecular	JJ	JJ	_	21	amod	_	_
21	size	size	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	65	65	CD	CD	_	24	nummod	_	_
24	kilodaltons	kilodalton	NNS	NNS	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	kD	kd	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	translated	translate	VBN	VBN	_	3	amod	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	weak	weak	JJ	JJ	_	7	amod	_	_
6	DNA	dna	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	4	dobj	_	_
8	with	with	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	specificity	specificity	NN	NN	_	7	nmod	_	_
11	for	for	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	kappa	kappa	NN	NN	_	16	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	motif	motif	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	protein-DNA	protein-dna	JJ	JJ	_	3	amod	_	_
3	complex	complex	JJ	JJ	_	4	nsubj	_	_
4	comigrated	comigrate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	complex	complex	NN	NN	_	4	nmod	_	_
8	obtained	obtain	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	purified	purify	VBN	VBN	_	16	amod	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	p65	p65	NN	NN	_	16	compound	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	8	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	binding	binding	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	inhibited	inhibit	VBN	VBN	_	4	conj	_	_
21	by	by	IN	IN	_	27	case	_	_
22	I	i	NN	NN	_	24	compound	_	_
23	kappa	kappa	NN	NN	_	24	compound	_	_
24	B-alpha	b-alpha	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	-beta	-beta	NN	NN	_	24	conj	_	_
27	proteins	protein	NNS	NNS	_	20	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	65-kD	65-kd	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	7	nsubj	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	p50	p50	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	probe	probe	NN	NN	_	11	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	form	form	VB	VB	_	7	xcomp	_	_
22	a	a	DT	DT	_	23	det	_	_
23	complex	complex	NN	NN	_	21	dobj	_	_
24	with	with	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	same	same	JJ	JJ	_	28	amod	_	_
27	electrophoretic	electrophoretic	JJ	JJ	_	28	amod	_	_
28	mobility	mobility	NN	NN	_	23	nmod	_	_
29	as	as	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	nmod:npmod	_	_
32	B-DNA	b-dna	JJ	JJ	_	33	amod	_	_
33	complex	complex	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	7	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	rel-related	rel-related	JJ	JJ	_	5	amod	_	_
4	65-kD	65-kd	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	represent	represent	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	p65	p65	NN	NN	_	10	compound	_	_
10	subunit	subunit	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	active	active	JJ	JJ	_	18	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
15	B	b	NN	NN	_	18	compound	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	number	number	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	posttraumatic	posttraumatic	JJ	JJ	_	8	amod	_	_
7	stress	stress	NN	NN	_	8	compound	_	_
8	disorder	disorder	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	authors	author	NNS	NNS	_	6	nmod:poss	_	_
5	'	'	POS	POS	_	4	case	_	_
6	objective	objective	NN	NN	_	7	nsubj	_	_
7	was	be	VBD	VBD	_	1	appos	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	investigate	investigate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	possibility	possibility	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	18	mark	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	changes	change	NNS	NNS	_	18	nsubjpass	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	involved	involve	VBN	VBN	_	11	ccomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	dysregulation	dysregulation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	28	amod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HPA	hpa	JJ	JJ	_	24	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	axis	axis	NN	NN	_	21	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	posttraumatic	posttraumatic	JJ	JJ	_	32	amod	_	_
31	stress	stress	NN	NN	_	32	compound	_	_
32	disorder	disorder	NN	NN	_	21	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PTSD	ptsd	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	7	punct	_	_

1	METHOD	method	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	They	they	PRP	PRP	_	4	nsubj	_	_
4	measured	measure	VBD	VBD	_	1	appos	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
9	cytosolic	cytosolic	JJ	JJ	_	11	amod	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	plasma	plasma	NN	NN	_	15	compound	_	_
14	cortisol	cortisol	NN	NN	_	15	compound	_	_
15	concentrations	concentration	NNS	NNS	_	6	conj	_	_
16	in	in	IN	IN	_	23	case	_	_
17	15	15	CD	CD	_	23	nummod	_	_
18	consecutively	consecutively	RB	RB	_	19	advmod	_	_
19	admitted	admit	VBN	VBN	_	23	amod	_	_
20	male	male	JJ	JJ	_	23	amod	_	_
21	combat	combat	NN	NN	_	23	compound	_	_
22	Vietnam	vietnam	NN	NN	_	23	compound	_	_
23	veterans	veteran	NNS	NNS	_	6	nmod	_	_
24	with	with	IN	IN	_	25	case	_	_
25	PTSD	ptsd	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	in	in	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	normal	normal	JJ	JJ	_	31	amod	_	_
30	comparison	comparison	NN	NN	_	31	compound	_	_
31	group	group	NN	NN	_	23	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	11	11	CD	CD	_	34	nummod	_	_
34	subjects	subject	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Both	both	CC	CC	_	5	cc:preconj	_	_
4	the	the	DT	DT	_	5	det	_	_
5	patients	patient	NNS	NNS	_	11	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	10	det	_	_
8	normal	normal	JJ	JJ	_	10	amod	_	_
9	comparison	comparison	NN	NN	_	10	compound	_	_
10	subjects	subject	NNS	NNS	_	5	conj	_	_
11	showed	show	VBD	VBD	_	1	appos	_	_
12	a	a	DT	DT	_	14	det	_	_
13	morning-to-afternoon	morning-to-afternoon	JJ	JJ	_	14	amod	_	_
14	decline	decline	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	concentrations	concentration	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	paralleling	parallel	VBG	VBG	_	14	acl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	normal	normal	JJ	JJ	_	24	amod	_	_
23	diurnal	diurnal	JJ	JJ	_	24	amod	_	_
24	decline	decline	NN	NN	_	20	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cortisol	cortisol	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	9	cop	_	_
7	63	63	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	9	nmod:npmod	_	_
9	greater	greater	JJR	JJR	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	morning	morning	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	26	26	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	16	nmod:npmod	_	_
16	greater	greater	JJR	JJR	_	9	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	afternoon	afternoon	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	patients	patient	NNS	NNS	_	9	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	PTSD	ptsd	NN	NN	_	22	nmod	_	_
25	than	than	IN	IN	_	29	case	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	normal	normal	JJ	JJ	_	29	amod	_	_
29	subjects	subject	NNS	NNS	_	9	advcl	_	_
30	.	.	.	.	_	9	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	group	group	NN	NN	_	3	compound	_	_
3	differences	difference	NNS	NNS	_	8	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	nor	nor	CC	CC	_	8	cc	_	_
11	were	be	VBD	VBD	_	18	aux	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	number	number	NN	NN	_	18	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cortisol	cortisol	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	14	conj	_	_
18	correlated	correlate	VBD	VBD	_	8	conj	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	morning	morning	NN	NN	_	6	compound	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	positively	positively	RB	RB	_	9	advmod	_	_
9	correlated	correlate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	symptoms	symptom	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PTSD	ptsd	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	anxiety	anxiety	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	1	appos	_	_
6	further	further	JJ	JJ	_	7	amod	_	_
7	evidence	evidence	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	dysregulation	dysregulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HPA	hpa	JJ	JJ	_	14	amod	_	_
14	axis	axis	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	PTSD	ptsd	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	21	nsubj	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	patients	patient	NNS	NNS	_	7	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PTSD	ptsd	NN	NN	_	4	nmod	_	_
7	had	have	VBD	VBD	_	2	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	substantially	substantially	RB	RB	_	10	advmod	_	_
10	greater	greater	JJR	JJR	_	11	amod	_	_
11	number	number	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	11	nmod	_	_
16	than	than	IN	IN	_	19	case	_	_
17	normal	normal	JJ	JJ	_	19	amod	_	_
18	comparison	comparison	NN	NN	_	19	compound	_	_
19	subjects	subject	NNS	NNS	_	11	nmod	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	consistent	consistent	JJ	JJ	_	0	root	_	_
22	with	with	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	authors	author	NNS	NNS	_	27	nmod:poss	_	_
25	'	'	POS	POS	_	24	case	_	_
26	previous	previous	JJ	JJ	_	27	amod	_	_
27	observations	observation	NNS	NNS	_	21	nmod	_	_
28	of	of	IN	IN	_	33	case	_	_
29	low	low	JJ	JJ	_	33	amod	_	_
30	24-hour	24-hour	JJ	JJ	_	33	amod	_	_
31	urinary	urinary	JJ	JJ	_	33	amod	_	_
32	cortisol	cortisol	NN	NN	_	33	compound	_	_
33	excretion	excretion	NN	NN	_	27	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	subjects	subject	NNS	NNS	_	33	nmod	_	_
36	with	with	IN	IN	_	37	case	_	_
37	PTSD	ptsd	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	changes	change	NNS	NNS	_	8	nsubj	_	_
6	observed	observe	VBN	VBN	_	5	acl	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	opposite	opposite	JJ	JJ	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	those	those	DT	DT	_	8	nmod	_	_
11	reported	report	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	15	case	_	_
13	major	major	JJ	JJ	_	15	amod	_	_
14	depressive	depressive	JJ	JJ	_	15	amod	_	_
15	disorder	disorder	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	15	nsubj	_	_
4	,	,	,	,	_	15	punct	_	_
5	along	along	IN	IN	_	8	case	_	_
6	with	with	IN	IN	_	8	case	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	findings	finding	NNS	NNS	_	15	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	HPA	hpa	JJ	JJ	_	11	amod	_	_
11	abnormalities	abnormality	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	PTSD	ptsd	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	15	punct	_	_
15	support	support	VBP	VBP	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	possibility	possibility	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	23	case	_	_
19	a	a	DT	DT	_	23	det	_	_
20	greater	greater	JJR	JJR	_	23	amod	_	_
21	negative	negative	JJ	JJ	_	23	amod	_	_
22	feedback	feedback	NN	NN	_	23	compound	_	_
23	sensitivity	sensitivity	NN	NN	_	17	nmod	_	_
24	at	at	IN	IN	_	28	case	_	_
25	one	one	CD	CD	_	28	nummod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	more	more	JJR	JJR	_	25	conj	_	_
28	levels	level	NNS	NNS	_	23	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	HPA	hpa	JJ	JJ	_	32	amod	_	_
32	axis	axis	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	Sex	sex	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	age	age	NN	NN	_	1	conj	_	_
4	distribution	distribution	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	1	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	receptors	receptor	NNS	NNS	_	9	nsubjpass	_	_
3	for	for	IN	IN	_	6	case	_	_
4	1,25	1,25	CD	CD	_	6	nummod	_	_
5	Dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	6	compound	_	_
6	D3	d3	NN	NN	_	2	nmod	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	described	describe	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PBMC	pbmc	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	tried	try	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	find	find	VB	VB	_	3	xcomp	_	_
6	out	out	RP	RP	_	5	compound:prt	_	_
7	whether	whether	IN	IN	_	11	mark	_	_
8	these	these	DT	DT	_	9	det	_	_
9	receptors	receptor	NNS	NNS	_	11	nsubj	_	_
10	could	could	MD	MD	_	11	aux	_	_
11	show	show	VB	VB	_	5	ccomp	_	_
12	any	any	DT	DT	_	13	det	_	_
13	difference	difference	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	sex	sex	NN	NN	_	11	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	age	age	NN	NN	_	15	conj	_	_
18	distribution	distribution	NN	NN	_	15	dep	_	_
19	.	.	.	.	_	3	punct	_	_

1	Twenty	twenty	CD	CD	_	2	compound	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	healthy	healthy	JJ	JJ	_	4	amod	_	_
4	men	man	NNS	NNS	_	30	nsubjpass	_	_
5	aged	aged	JJ	JJ	_	4	amod	_	_
6	21-66	21-66	CD	CD	_	7	nummod	_	_
7	yr	yr	NN	NN	_	5	dep	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	mean	mean	NN	NN	_	4	dep	_	_
10	+/-	+/-	CC	CC	_	9	cc	_	_
11	SD	sd	NN	NN	_	9	conj	_	_
12	41.0	41.0	CD	CD	_	9	dep	_	_
13	+/-	+/-	CC	CC	_	12	cc	_	_
14	13.6	13.6	CD	CD	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	9	punct	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	nineteen	nineteen	CD	CD	_	19	nummod	_	_
18	healthy	healthy	JJ	JJ	_	19	amod	_	_
19	women	woman	NNS	NNS	_	4	conj	_	_
20	aged	aged	JJ	JJ	_	19	amod	_	_
21	22-60	22-60	CD	CD	_	22	nummod	_	_
22	yr	yr	NN	NN	_	20	dep	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	38.9	38.9	CD	CD	_	19	appos	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	13.9	13.9	CD	CD	_	24	conj	_	_
27	)	)	-RRB-	-RRB-	_	24	punct	_	_
28	have	have	VBP	VBP	_	30	aux	_	_
29	been	be	VBN	VBN	_	30	auxpass	_	_
30	studied	study	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	mean	mean	NN	NN	_	4	compound	_	_
3	dissociation	dissociation	NN	NN	_	4	compound	_	_
4	constant	constant	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Kd	kd	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	sexes	sex	NNS	NNS	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	19	punct	_	_
14	1.35	1.35	CD	CD	_	19	nummod	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	0.70	0.70	CD	CD	_	14	conj	_	_
17	x	x	CC	CC	_	16	cc	_	_
18	10(-10)	10(-10)	CD	CD	_	16	conj	_	_
19	M	m	NN	NN	_	9	dep	_	_
20	in	in	IN	IN	_	21	case	_	_
21	males	male	NNS	NNS	_	19	nmod	_	_
22	,	,	,	,	_	19	punct	_	_
23	1.13	1.13	CD	CD	_	28	nummod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	0.66	0.66	CD	CD	_	23	conj	_	_
26	x	x	CC	CC	_	25	cc	_	_
27	10(-10)	10(-10)	CD	CD	_	25	conj	_	_
28	M	m	NN	NN	_	19	appos	_	_
29	in	in	IN	IN	_	30	case	_	_
30	females	female	NNS	NNS	_	28	nmod	_	_
31	)	)	-RRB-	-RRB-	_	19	punct	_	_
32	,	,	,	,	_	9	punct	_	_
33	but	but	CC	CC	_	9	cc	_	_
34	the	the	DT	DT	_	35	det	_	_
35	concentration	concentration	NN	NN	_	44	nsubj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	binding	bind	VBG	VBG	_	38	amod	_	_
38	sites	site	NNS	NNS	_	35	nmod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	Nmax	nmax	NN	NN	_	35	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	was	be	VBD	VBD	_	44	cop	_	_
43	significantly	significantly	RB	RB	_	44	advmod	_	_
44	lower	lower	JJR	JJR	_	9	conj	_	_
45	in	in	IN	IN	_	46	case	_	_
46	females	female	NNS	NNS	_	44	nmod	_	_
47	(	(	-LRB-	-LRB-	_	52	punct	_	_
48	2.32	2.32	CD	CD	_	52	dep	_	_
49	+/-	+/-	CC	CC	_	48	cc	_	_
50	0.92	0.92	CD	CD	_	48	conj	_	_
51	fmol/10(7)	fmol/10(7)	CD	CD	_	48	compound	_	_
52	PBMC	pbmc	NNS	NNS	_	44	dep	_	_
53	vs	vs	CC	CC	_	52	cc	_	_
54	4.43	4.43	CD	CD	_	57	dep	_	_
55	+/-	+/-	CC	CC	_	54	cc	_	_
56	1.38	1.38	CD	CD	_	54	conj	_	_
57	fmol/10(7)	fmol/10(7)	NN	NN	_	58	dep	_	_
58	PBMC	pbmc	NNS	NNS	_	52	conj	_	_
59	in	in	IN	IN	_	60	case	_	_
60	males	male	NNS	NNS	_	58	nmod	_	_
61	;	;	:	:	_	52	punct	_	_
62	p	p	NN	NN	_	52	dep	_	_
63	=	=	JJ	JJ	_	62	amod	_	_
64	0.0001	0.0001	CD	CD	_	63	dep	_	_
65	)	)	-RRB-	-RRB-	_	52	punct	_	_
66	.	.	.	.	_	9	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	Kd	kd	NN	NN	_	7	nsubjpass	_	_
3	nor	nor	CC	CC	_	2	cc	_	_
4	Nmax	nmax	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	correlated	correlate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	age	age	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	7	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	difference	difference	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	6	case	_	_
6	pre	pre	JJ	JJ	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	postmenopausal	postmenopausal	JJ	JJ	_	6	conj	_	_
9	women	woman	NNS	NNS	_	6	dep	_	_
10	.	.	.	.	_	4	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	needed	need	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	elucidate	elucidate	VB	VB	_	4	xcomp	_	_
7	if	if	IN	IN	_	22	mark	_	_
8	this	this	DT	DT	_	10	det	_	_
9	sex	sex	NN	NN	_	10	compound	_	_
10	difference	difference	NN	NN	_	22	nsubj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	PBMC	pbmc	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	10	nmod	_	_
14	for	for	IN	IN	_	17	case	_	_
15	1.25	1.25	CD	CD	_	17	nummod	_	_
16	Dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	17	compound	_	_
17	D3	d3	NN	NN	_	13	nmod	_	_
18	is	be	VBZ	VBZ	_	22	cop	_	_
19	of	of	IN	IN	_	22	case	_	_
20	any	any	DT	DT	_	22	det	_	_
21	pathophysiological	pathophysiological	JJ	JJ	_	22	amod	_	_
22	relevance	relevance	NN	NN	_	6	advcl	_	_
23	.	.	.	.	_	4	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	down-regulation	down-regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-myc	c-myc	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	protein	protein	NN	NN	_	5	nmod	_	_
8	synthesis-dependent	synthesis-dependent	JJ	JJ	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	-independent	-independent	JJ	JJ	_	7	conj	_	_
11	pathways	pathway	NNS	NNS	_	7	dep	_	_
12	in	in	IN	IN	_	19	case	_	_
13	a	a	DT	DT	_	19	det	_	_
14	human	human	JJ	JJ	_	19	amod	_	_
15	T	t	NN	NN	_	19	compound	_	_
16	lymphoblastic	lymphoblastic	JJ	JJ	_	19	amod	_	_
17	tumor	tumor	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	7	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	in	in	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	T	t	NN	NN	_	11	compound	_	_
8	lymphoblastic	lymphoblastic	JJ	JJ	_	11	amod	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	19	nmod	_	_
12	Molt4	molt4	NN	NN	_	14	compound	_	_
13	c-myc	c-myc	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	19	nsubjpass	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	conj	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	down-regulated	down-regulate	VBN	VBN	_	2	ccomp	_	_
20	after	after	IN	IN	_	21	case	_	_
21	exposure	exposure	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	dimethyl	dimethyl	JJ	JJ	_	24	amod	_	_
24	sulfoxide	sulfoxide	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	to	to	TO	TO	_	29	case	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	myristate	myristate	NN	NN	_	29	compound	_	_
29	acetate	acetate	NN	NN	_	24	conj	_	_
30	,	,	,	,	_	24	punct	_	_
31	or	or	CC	CC	_	24	cc	_	_
32	to	to	TO	TO	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	calcium	calcium	NN	NN	_	36	compound	_	_
35	ionophore	ionophore	NN	NN	_	36	compound	_	_
36	A23187	a23187	NN	NN	_	24	conj	_	_
37	,	,	,	,	_	36	punct	_	_
38	which	which	WDT	WDT	_	39	nsubj	_	_
39	raises	raise	VBZ	VBZ	_	36	acl:relcl	_	_
40	the	the	DT	DT	_	43	det	_	_
41	intracellular	intracellular	JJ	JJ	_	43	amod	_	_
42	calcium	calcium	NN	NN	_	43	compound	_	_
43	concentration	concentration	NN	NN	_	39	dobj	_	_
44	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	block	block	NN	NN	_	8	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	RNA	rna	NN	NN	_	5	compound	_	_
5	elongation	elongation	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	largely	largely	RB	RB	_	8	advmod	_	_
8	responsible	responsible	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	12	case	_	_
10	decreased	decrease	VBN	VBN	_	12	amod	_	_
11	c-myc	c-myc	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	7	nsubj	_	_
4	by	by	IN	IN	_	6	case	_	_
5	dimethyl	dimethyl	JJ	JJ	_	6	amod	_	_
6	sulfoxide	sulfoxide	NN	NN	_	3	nmod	_	_
7	takes	take	VBZ	VBZ	_	24	advcl	_	_
8	place	place	NN	NN	_	7	dobj	_	_
9	even	even	RB	RB	_	10	advmod	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	inhibited	inhibit	VBN	VBN	_	7	advcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	cycloheximide	cycloheximide	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	24	punct	_	_
18	the	the	DT	DT	_	22	det	_	_
19	phorbol	phorbol	NN	NN	_	22	compound	_	_
20	myristate	myristate	NN	NN	_	22	compound	_	_
21	acetate	acetate	NN	NN	_	22	compound	_	_
22	effect	effect	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	blocked	block	VBN	VBN	_	0	root	_	_
25	to	to	TO	TO	_	27	case	_	_
26	some	some	DT	DT	_	27	det	_	_
27	extent	extent	NN	NN	_	24	nmod	_	_
28	only	only	RB	RB	_	30	advmod	_	_
29	by	by	IN	IN	_	30	case	_	_
30	cycloheximide	cycloheximide	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	calcium	calcium	NN	NN	_	5	compound	_	_
3	ionophore-induced	ionophore-induced	JJ	JJ	_	5	amod	_	_
4	c-myc	c-myc	NN	NN	_	5	compound	_	_
5	suppression	suppression	NN	NN	_	10	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	however	however	RB	RB	_	10	advmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	strictly	strictly	RB	RB	_	10	advmod	_	_
10	requires	require	VBZ	VBZ	_	0	root	_	_
11	de	de	FW	FW	_	14	amod	_	_
12	novo	novo	FW	FW	_	11	dep	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	synthesis	synthesis	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	Therefore	therefore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	two	two	CD	CD	_	7	nummod	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	negative	negative	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	pathways	pathway	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	c-myc	c-myc	NN	NN	_	12	compound	_	_
12	regulation	regulation	NN	NN	_	9	nmod	_	_
13	:	:	:	:	_	9	punct	_	_
14	one	one	CD	CD	_	9	dep	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	independent	independent	JJ	JJ	_	14	acl:relcl	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	one	one	CD	CD	_	14	conj	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	depends	depend	VBZ	VBZ	_	19	acl:relcl	_	_
22	on	on	IN	IN	_	26	case	_	_
23	de	de	FW	FW	_	26	amod	_	_
24	novo	novo	FW	FW	_	23	dep	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	synthesis	synthesis	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	one	one	CD	CD	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	4	xcomp	_	_
8	by	by	IN	IN	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	rapidly	rapidly	RB	RB	_	12	advmod	_	_
11	calcium-dependent	calcium-dependent	JJ	JJ	_	12	dep	_	_
12	induced	induce	VBN	VBN	_	14	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	product	product	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
3	virus	virus	NN	NN	_	6	compound	_	_
4	type-2	type-2	JJ	JJ	_	6	amod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	0	root	_	_
7	:	:	:	:	_	6	punct	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	enhancers	enhancer	NNS	NNS	_	6	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	activation	activation	NN	NN	_	9	conj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	activators	activator	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
4	viruses	virus	NNS	NNS	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIVs	hiv	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	include	include	VB	VB	_	0	root	_	_
10	a	a	DT	DT	_	11	det	_	_
11	spectrum	spectrum	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	retroviruses	retrovirus	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	varying	vary	VBG	VBG	_	16	amod	_	_
16	potential	potential	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	infect	infect	VB	VB	_	16	acl	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	host	host	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	18	punct	_	_
22	undergo	undergo	VB	VB	_	18	conj	_	_
23	long	long	JJ	JJ	_	24	amod	_	_
24	periods	period	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	latent	latent	JJ	JJ	_	27	amod	_	_
27	infection	infection	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	18	punct	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	induce	induce	VB	VB	_	18	conj	_	_
31	pathology	pathology	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	10	mark	_	_
2	expression	expression	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	viruses	virus	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	10	auxpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	large	large	JJ	JJ	_	9	amod	_	_
9	part	part	NN	NN	_	10	nmod	_	_
10	regulated	regulate	VBN	VBN	_	27	advcl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	sequence	sequence	NN	NN	_	14	compound	_	_
14	elements	element	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	terminal	terminal	JJ	JJ	_	19	amod	_	_
19	repeats	repeat	NNS	NNS	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	LTRs	ltr	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	27	punct	_	_
24	this	this	DT	DT	_	25	det	_	_
25	study	study	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	directed	direct	VBN	VBN	_	0	root	_	_
28	to	to	TO	TO	_	30	case	_	_
29	an	a	DT	DT	_	30	det	_	_
30	analysis	analysis	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	regulatory	regulatory	JJ	JJ	_	34	amod	_	_
34	elements	element	NNS	NNS	_	30	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	HIV-2	hiv-2	NN	NN	_	38	compound	_	_
38	LTR	ltr	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HIV-2	hiv-2	NN	NN	_	3	compound	_	_
3	LTR	ltr	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	contain	contain	VB	VB	_	5	xcomp	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	enhancers	enhancer	NNS	NNS	_	7	dobj	_	_
10	.	.	.	.	_	5	punct	_	_

1	One	one	CD	CD	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	enhancers	enhancer	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	,	,	,	,	_	10	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	part	part	NN	NN	_	10	nmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	identical	identical	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	10	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	HIV-1	hiv-1	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	the	the	DT	DT	_	10	det	_	_
7	T-cell	t-cell	NN	NN	_	10	compound	_	_
8	activation	activation	NN	NN	_	10	compound	_	_
9	response	response	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	0	root	_	_
11	;	;	:	:	_	10	punct	_	_
12	in	in	IN	IN	_	13	case	_	_
13	HIV-2	hiv-2	NN	NN	_	21	nmod	_	_
14	,	,	,	,	_	21	punct	_	_
15	however	however	RB	RB	_	21	advmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	it	it	PRP	PRP	_	21	nsubj	_	_
18	is	be	VBZ	VBZ	_	21	cop	_	_
19	the	the	DT	DT	_	21	det	_	_
20	second	second	JJ	JJ	_	21	amod	_	_
21	enhancer	enhancer	NN	NN	_	10	parataxis	_	_
22	that	that	WDT	WDT	_	25	nsubj	_	_
23	is	be	VBZ	VBZ	_	25	cop	_	_
24	mainly	mainly	RB	RB	_	25	advmod	_	_
25	responsible	responsible	JJ	JJ	_	21	acl:relcl	_	_
26	for	for	IN	IN	_	27	case	_	_
27	activation	activation	NN	NN	_	25	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	response	response	NN	NN	_	27	nmod	_	_
30	to	to	TO	TO	_	32	case	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	activators	activator	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	enhancer	enhancer	NN	NN	_	4	nsubj	_	_
4	interacts	interact	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	9	case	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	85	85	CD	CD	_	12	nummod	_	_
12	kD	kd	NN	NN	_	9	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	27	27	CD	CD	_	15	nummod	_	_
15	kD	kd	NN	NN	_	12	conj	_	_
16	mobility	mobility	NN	NN	_	12	dep	_	_
17	)	)	-RRB-	-RRB-	_	12	punct	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	appear	appear	VBP	VBP	_	9	acl:relcl	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	required	require	VBN	VBN	_	19	xcomp	_	_
23	for	for	IN	IN	_	25	case	_	_
24	optimal	optimal	JJ	JJ	_	25	amod	_	_
25	enhancer	enhancer	NN	NN	_	22	nmod	_	_
26	function	function	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	activation	activation	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	Observations	observation	NNS	NNS	_	5	nsubj	_	_
2	such	such	JJ	JJ	_	4	case	_	_
3	as	as	IN	IN	_	2	mwe	_	_
4	these	these	DT	DT	_	1	nmod	_	_
5	encourage	encourage	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	speculation	speculation	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	there	there	EX	EX	_	13	expl	_	_
10	may	may	MD	MD	_	13	aux	_	_
11	be	be	VB	VB	_	13	cop	_	_
12	subtle	subtle	JJ	JJ	_	13	amod	_	_
13	differences	difference	NNS	NNS	_	7	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	regulation	regulation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HIV-1	hiv-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	HIV-2	hiv-2	NN	NN	_	18	conj	_	_
21	expression	expression	NN	NN	_	18	dep	_	_
22	that	that	WDT	WDT	_	25	nsubj	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	relevant	relevant	JJ	JJ	_	13	dep	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	possible	possible	JJ	JJ	_	30	amod	_	_
29	longer	longer	JJR	JJR	_	28	dep	_	_
30	latency	latency	NN	NN	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	reduced	reduce	VBN	VBN	_	33	amod	_	_
33	pathogenicity	pathogenicity	NN	NN	_	30	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	HIV-2	hiv-2	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	signals	signal	NNS	NNS	_	1	nmod	_	_
4	required	require	VBN	VBN	_	3	acl	_	_
5	for	for	IN	IN	_	6	case	_	_
6	activation	activation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	transcription	transcription	NN	NN	_	11	compound	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	constitutively	constitutively	RB	RB	_	15	advmod	_	_
15	expressing	express	VBG	VBG	_	13	acl	_	_
16	the	the	DT	DT	_	19	det	_	_
17	HTLV-I	htlv-i	NN	NN	_	19	compound	_	_
18	Tax	tax	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	15	dobj	_	_
20	.	.	.	.	_	1	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	short-term	short-term	JJ	JJ	_	1	dep	_	_
3	expression	expression	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Tax	tax	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	T-cell	t-cell	NN	NN	_	13	compound	_	_
11	leukemia	leukemia	NN	NN	_	13	compound	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	type-I	type-i	NN	NN	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HTLV-I	htlv-i	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	leads	lead	VBZ	VBZ	_	0	root	_	_
18	to	to	TO	TO	_	19	case	_	_
19	activation	activation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	pleiotropic	pleiotropic	JJ	JJ	_	26	amod	_	_
23	transcription	transcription	NN	NN	_	26	compound	_	_
24	factor	factor	NN	NN	_	26	compound	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Consistent	consistent	JJ	JJ	_	11	advmod	_	_
2	with	with	IN	IN	_	3	case	_	_
3	findings	finding	NNS	NNS	_	1	nmod	_	_
4	obtained	obtain	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	8	case	_	_
6	transient	transient	JJ	JJ	_	8	amod	_	_
7	expression	expression	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	observed	observe	VBD	VBD	_	0	root	_	_
12	marked	marked	JJ	JJ	_	13	amod	_	_
13	accumulation	accumulation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	transcription	transcription	NN	NN	_	19	compound	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	13	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	nucleus	nucleus	NN	NN	_	11	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	Namalwa	namalwa	NN	NN	_	27	compound	_	_
25	B	b	NN	NN	_	27	compound	_	_
26	lymphoid	lymphoid	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	which	which	WDT	WDT	_	31	nsubj	_	_
30	constitutively	constitutively	RB	RB	_	31	advmod	_	_
31	express	express	VBP	VBP	_	27	acl:relcl	_	_
32	Tax	tax	NN	NN	_	31	dobj	_	_
33	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	nucleus	nucleus	NN	NN	_	9	nmod	_	_
13	following	follow	VBG	VBG	_	15	case	_	_
14	long-term	long-term	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Tax	tax	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	Jurkat	jurkat	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	mitogens	mitogen	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cytokines	cytokine	NNS	NNS	_	5	conj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	2	acl	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	9	dobj	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	constitutively	constitutively	RB	RB	_	19	advmod	_	_
19	expressing	express	VBG	VBG	_	17	acl	_	_
20	Tax	tax	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	other	other	JJ	JJ	_	9	amod	_	_
7	mitogen-inducible	mitogen-inducible	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	such	such	JJ	JJ	_	13	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	Fos	fos	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Jun	jun	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	unaffected	unaffected	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Thus	thus	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	depending	depend	VBG	VBG	_	7	case	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	environment	environment	NN	NN	_	20	advcl	_	_
8	,	,	,	,	_	20	punct	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	short-	short-	JJ	JJ	_	20	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	long-term	long-term	JJ	JJ	_	10	conj	_	_
13	effects	effect	NNS	NNS	_	10	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	Tax	tax	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	10	nmod	_	_
17	can	can	MD	MD	_	20	aux	_	_
18	be	be	VB	VB	_	20	cop	_	_
19	quite	quite	RB	RB	_	20	advmod	_	_
20	different	different	JJ	JJ	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Consequently	consequently	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	one	one	CD	CD	_	4	nummod	_	_
4	function	function	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Tax	tax	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	cells	cell	NNS	NNS	_	6	nmod	_	_
9	infected	infect	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	HTLV-I	htlv-i	NN	NN	_	9	nmod	_	_
12	might	might	MD	MD	_	13	aux	_	_
13	involve	involve	VB	VB	_	0	root	_	_
14	cell-type-specific	cell-type-specific	JJ	JJ	_	15	amod	_	_
15	suppression	suppression	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	13	punct	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	opposed	oppose	VBN	VBN	_	13	dep	_	_
19	to	to	TO	TO	_	20	case	_	_
20	activation	activation	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	of	of	IN	IN	_	25	case	_	_
23	distinct	distinct	JJ	JJ	_	25	amod	_	_
24	signal	signal	NN	NN	_	25	compound	_	_
25	pathways	pathway	NNS	NNS	_	13	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cells	cell	NNS	NNS	_	3	compound	_	_
3	lines	line	NNS	NNS	_	8	nsubj	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	here	here	RB	RB	_	3	advmod	_	_
6	should	should	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	useful	useful	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	delineation	delineation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	pathways	pathway	NNS	NNS	_	11	nmod	_	_
15	utilized	utilize	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	selective	selective	JJ	JJ	_	19	amod	_	_
19	regulation	regulation	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	thymus-specific	thymus-specific	JJ	JJ	_	3	amod	_	_
3	member	member	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	HMG	hmg	NN	NN	_	8	compound	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	3	nmod	_	_
9	regulates	regulate	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	17	det	_	_
11	human	human	JJ	JJ	_	17	amod	_	_
12	T	t	NN	NN	_	17	compound	_	_
13	cell	cell	NN	NN	_	17	compound	_	_
14	receptor	receptor	NN	NN	_	17	compound	_	_
15	C	c	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	enhancer	enhancer	NN	NN	_	9	dobj	_	_
18	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	nmod:npmod	_	_
4	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	9	nsubj	_	_
7	TCF-1	tcf-1	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	6	dep	_	_
9	plays	play	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	key	key	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	tissue-specific	tissue-specific	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	9	nmod	_	_
17	of	of	IN	IN	_	27	case	_	_
18	the	the	DT	DT	_	27	det	_	_
19	T	t	NN	NN	_	27	compound	_	_
20	cell	cell	NN	NN	_	27	compound	_	_
21	receptor	receptor	NN	NN	_	27	compound	_	_
22	(	(	-LRB-	-LRB-	_	27	punct	_	_
23	TCR	tcr	NN	NN	_	27	compound	_	_
24	)	)	-RRB-	-RRB-	_	27	punct	_	_
25	C	c	NN	NN	_	27	compound	_	_
26	alpha	alpha	NN	NN	_	27	compound	_	_
27	enhancer	enhancer	NN	NN	_	16	nmod	_	_
28	and	and	CC	CC	_	9	cc	_	_
29	binds	bind	VBZ	VBZ	_	9	conj	_	_
30	to	to	TO	TO	_	32	case	_	_
31	pyrimidine-rich	pyrimidine-rich	JJ	JJ	_	32	amod	_	_
32	elements	element	NNS	NNS	_	29	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	5'-PyCTTTG-3'	5'-pyctttg-3'	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	present	present	JJ	JJ	_	32	amod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	a	a	DT	DT	_	39	det	_	_
39	variety	variety	NN	NN	_	36	nmod	_	_
40	of	of	IN	IN	_	45	case	_	_
41	other	other	JJ	JJ	_	45	amod	_	_
42	T	t	NN	NN	_	43	nmod:npmod	_	_
43	cell-specific	cell-specific	JJ	JJ	_	45	amod	_	_
44	control	control	NN	NN	_	45	compound	_	_
45	regions	region	NNS	NNS	_	39	nmod	_	_
46	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	16	advcl	_	_
2	amino	amino	NN	NN	_	5	compound	_	_
3	acid	acid	NN	NN	_	5	compound	_	_
4	sequence	sequence	NN	NN	_	5	compound	_	_
5	information	information	NN	NN	_	1	dobj	_	_
6	derived	derive	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	DNA	dna	NN	NN	_	11	compound	_	_
10	affinity-purified	affinity-purified	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	we	we	PRP	PRP	_	16	nsubj	_	_
14	have	have	VBP	VBP	_	16	aux	_	_
15	now	now	RB	RB	_	16	advmod	_	_
16	isolated	isolate	VBN	VBN	_	0	root	_	_
17	cDNA	cdna	NN	NN	_	18	compound	_	_
18	clones	clone	NNS	NNS	_	16	dobj	_	_
19	encoding	encode	VBG	VBG	_	18	acl	_	_
20	TCF-1	tcf-1	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	TCF-1	tcf-1	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	cDNA	cdna	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	single	single	JJ	JJ	_	9	amod	_	_
8	68-amino-acid	68-amino-acid	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	homologous	homologous	JJ	JJ	_	9	acl:relcl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	region	region	NN	NN	_	12	nmod	_	_
16	conserved	conserve	VBN	VBN	_	15	acl	_	_
17	among	among	IN	IN	_	19	case	_	_
18	high-mobility	high-mobility	JJ	JJ	_	19	amod	_	_
19	group	group	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	HMG	hmg	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	nonhistone	nonhistone	JJ	JJ	_	26	amod	_	_
25	chromosomal	chromosomal	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	19	conj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	full-length	full-length	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	mutant	mutant	JJ	JJ	_	3	conj	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	clones	clone	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	bacteria	bacterium	NNS	NNS	_	1	nmod	_	_
10	reveal	reveal	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	28	mark	_	_
12	the	the	DT	DT	_	15	det	_	_
13	single	single	JJ	JJ	_	15	amod	_	_
14	HMG	hmg	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	28	nsubj	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	predicted	predict	VBN	VBN	_	15	acl:relcl	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	contain	contain	VB	VB	_	19	xcomp	_	_
22	two	two	CD	CD	_	25	nummod	_	_
23	extended	extend	VBN	VBN	_	25	amod	_	_
24	alpha-helical	alpha-helical	JJ	JJ	_	25	amod	_	_
25	segments	segment	NNS	NNS	_	21	dobj	_	_
26	,	,	,	,	_	15	punct	_	_
27	is	be	VBZ	VBZ	_	28	cop	_	_
28	sufficient	sufficient	JJ	JJ	_	10	ccomp	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	direct	direct	VB	VB	_	28	xcomp	_	_
31	the	the	DT	DT	_	33	det	_	_
32	sequence-specific	sequence-specific	JJ	JJ	_	33	amod	_	_
33	binding	binding	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	TCF-1	tcf-1	NN	NN	_	36	compound	_	_
36	alpha	alpha	NN	NN	_	33	nmod	_	_
37	to	to	TO	TO	_	38	case	_	_
38	DNA	dna	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	further	further	RBR	RBR	_	4	advmod	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	TCF-1	tcf-1	NN	NN	_	9	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	13	nsubj	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	highly	highly	RB	RB	_	13	advmod	_	_
12	tissue	tissue	NN	NN	_	13	nmod:npmod	_	_
13	specific	specific	JJ	JJ	_	4	ccomp	_	_
14	,	,	,	,	_	13	punct	_	_
15	found	find	VBN	VBN	_	13	dep	_	_
16	primarily	primarily	RB	RB	_	15	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	thymus	thymus	NN	NN	_	15	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	19	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	immature	immature	JJ	JJ	_	6	amod	_	_
3	CEM	cem	NN	NN	_	6	compound	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	7	nsubj	_	_
7	expresses	express	VBZ	VBZ	_	0	root	_	_
8	relatively	relatively	RB	RB	_	10	advmod	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	TCF-1	tcf-1	NN	NN	_	14	compound	_	_
13	alpha	alpha	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	increased	increase	VBN	VBN	_	10	acl:relcl	_	_
19	upon	upon	IN	IN	_	20	case	_	_
20	activation	activation	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	phorbol	phorbol	NN	NN	_	26	compound	_	_
26	esters	ester	NNS	NNS	_	20	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	cloned	clone	VBN	VBN	_	7	amod	_	_
5	TCF-1	tcf-1	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	potent	potent	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activator	activator	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	TCR	tcr	NN	NN	_	18	compound	_	_
17	alpha	alpha	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	nonlymphoid	nonlymphoid	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	whereas	whereas	IN	IN	_	12	dep	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activity	activity	NN	NN	_	37	nsubj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	endogenous	endogenous	JJ	JJ	_	30	amod	_	_
30	protein	protein	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	30	nmod	_	_
35	is	be	VBZ	VBZ	_	37	cop	_	_
36	strongly	strongly	RB	RB	_	37	advmod	_	_
37	dependent	dependent	JJ	JJ	_	12	parataxis	_	_
38	on	on	IN	IN	_	43	case	_	_
39	an	a	DT	DT	_	43	det	_	_
40	additional	additional	JJ	JJ	_	43	amod	_	_
41	T	t	NN	NN	_	42	nmod:npmod	_	_
42	cell-specific	cell-specific	JJ	JJ	_	43	amod	_	_
43	protein	protein	NN	NN	_	37	nmod	_	_
44	that	that	WDT	WDT	_	45	nsubj	_	_
45	interacts	interact	VBZ	VBZ	_	43	acl:relcl	_	_
46	with	with	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	core	core	NN	NN	_	49	compound	_	_
49	enhancer	enhancer	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	12	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	currently	currently	RB	RB	_	5	advmod	_	_
5	unique	unique	JJ	JJ	_	0	root	_	_
6	among	among	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	newly	newly	RB	RB	_	9	advmod	_	_
9	emerging	emerge	VBG	VBG	_	10	amod	_	_
10	family	family	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	10	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	share	share	VBP	VBP	_	14	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	HMG	hmg	NN	NN	_	19	compound	_	_
19	motif	motif	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	that	that	IN	IN	_	31	nmod	_	_
22	it	it	PRP	PRP	_	31	nsubj	_	_
23	is	be	VBZ	VBZ	_	31	cop	_	_
24	a	a	DT	DT	_	31	det	_	_
25	highly	highly	RB	RB	_	26	advmod	_	_
26	tissue-specific	tissue-specific	JJ	JJ	_	31	amod	_	_
27	RNA	rna	NN	NN	_	31	compound	_	_
28	polymerase	polymerase	NN	NN	_	31	compound	_	_
29	II	ii	CD	CD	_	31	nummod	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	19	acl:relcl	_	_
32	.	.	.	.	_	5	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	response	response	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	HBx-antigen	hbx-antigen	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	hepatitis	hepatitis	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	virus	virus	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	hepatitis	hepatitis	NN	NN	_	5	compound	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	genome	genome	NN	NN	_	6	nsubj	_	_
6	encodes	encode	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	transactivator	transactivator	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	dobj	_	_
11	designated	designate	VBN	VBN	_	10	acl	_	_
12	HBxAg	hbxag	NN	NN	_	11	xcomp	_	_
13	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	whether	whether	IN	IN	_	10	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	antigen	antigen	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	structure	structure	NN	NN	_	3	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	T-lymphocytes	t-lymphocyte	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	7	advcl	_	_
2	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
3	HBxAg	hbxag	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	found	find	VBD	VBD	_	0	root	_	_
8	HBxAg-specific	hbxag-specific	JJ	JJ	_	9	amod	_	_
9	stimulation	stimulation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	7	nmod	_	_
17	with	with	IN	IN	_	22	case	_	_
18	acute	acute	JJ	JJ	_	22	amod	_	_
19	hepatitis	hepatitis	NN	NN	_	22	compound	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	infection	infection	NN	NN	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	6	6	CD	CD	_	22	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	6	6	CD	CD	_	24	nmod	_	_
27	)	)	-RRB-	-RRB-	_	24	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	chronic	chronic	JJ	JJ	_	33	amod	_	_
30	hepatitis	hepatitis	NN	NN	_	33	compound	_	_
31	B	b	NN	NN	_	33	compound	_	_
32	virus	virus	NN	NN	_	33	compound	_	_
33	infection	infection	NN	NN	_	22	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	6	6	CD	CD	_	33	dep	_	_
36	of	of	IN	IN	_	37	case	_	_
37	17	17	CD	CD	_	35	nmod	_	_
38	)	)	-RRB-	-RRB-	_	35	punct	_	_
39	but	but	CC	CC	_	16	cc	_	_
40	not	not	RB	RB	_	43	neg	_	_
41	in	in	IN	IN	_	43	case	_	_
42	healthy	healthy	JJ	JJ	_	43	amod	_	_
43	individuals	individual	NNS	NNS	_	16	conj	_	_
44	.	.	.	.	_	7	punct	_	_

1	With	with	IN	IN	_	4	case	_	_
2	HBxAg-specific	hbxag-specific	JJ	JJ	_	4	amod	_	_
3	synthetic	synthetic	JJ	JJ	_	4	amod	_	_
4	polypeptides	polypeptide	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	several	several	JJ	JJ	_	8	amod	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	epitopes	epitope	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Most	most	JJS	JJS	_	3	nsubj	_	_
2	were	be	VBD	VBD	_	3	aux	_	_
3	located	located	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	carboxyterminal	carboxyterminal	JJ	JJ	_	7	amod	_	_
7	half	half	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HBxAg	hbxag	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Five	five	CD	CD	_	3	nummod	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	17	nsubjpass	_	_
4	specific	specific	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	epitope	epitope	NN	NN	_	4	nmod	_	_
9	located	located	JJ	JJ	_	8	dep	_	_
10	at	at	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	carboxyterminal	carboxyterminal	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	HBxAg	hbxag	NN	NN	_	13	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	established	establish	VBN	VBN	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	found	find	VBN	VBN	_	17	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	belong	belong	VB	VB	_	19	xcomp	_	_
22	to	to	TO	TO	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	CD2/CD4-positive	cd2/cd4-positive	JJ	JJ	_	27	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	CD8-negative	cd8-negative	JJ	JJ	_	24	dep	_	_
27	subtype	subtype	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	HBxAg	hbxag	NN	NN	_	3	dobj	_	_
9	as	as	IN	IN	_	11	case	_	_
10	an	a	DT	DT	_	11	det	_	_
11	antigen	antigen	NN	NN	_	3	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	0	root	_	_
3	on	on	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	circadian	circadian	JJ	JJ	_	6	amod	_	_
6	rhythm	rhythm	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Circadian	circadian	JJ	JJ	_	2	amod	_	_
2	rhythm	rhythm	NN	NN	_	10	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	GR	gr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	studied	study	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	rat	rat	NN	NN	_	14	compound	_	_
14	liver	liver	NN	NN	_	18	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	peripheral	peripheral	JJ	JJ	_	14	conj	_	_
18	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	rats	rat	NNS	NNS	_	25	nmod	_	_
3	exposed	expose	VBN	VBN	_	2	acl	_	_
4	to	to	TO	TO	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	natural	natural	JJ	JJ	_	7	amod	_	_
7	environmental	environmental	JJ	JJ	_	9	amod	_	_
8	photic	photic	JJ	JJ	_	9	amod	_	_
9	cycle	cycle	NN	NN	_	3	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	17	det	_	_
12	12L	12l	NN	NN	_	17	compound	_	_
13	:	:	:	:	_	17	punct	_	_
14	12D	12d	NN	NN	_	17	compound	_	_
15	artificial	artificial	JJ	JJ	_	17	amod	_	_
16	light	light	NN	NN	_	17	compound	_	_
17	regime	regime	NN	NN	_	9	conj	_	_
18	,	,	,	,	_	25	punct	_	_
19	peak	peak	JJ	JJ	_	20	amod	_	_
20	values	value	NNS	NNS	_	25	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	hepatic	hepatic	JJ	JJ	_	23	amod	_	_
23	GR	gr	NN	NN	_	20	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	detected	detect	VBN	VBN	_	0	root	_	_
26	between	between	IN	IN	_	30	case	_	_
27	23:00	23:00	CD	CD	_	30	nummod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	02:00	02:00	CD	CD	_	27	conj	_	_
30	h	h	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	25	punct	_	_

1	Except	except	IN	IN	_	5	case	_	_
2	for	for	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	4-hour	4-hour	JJ	JJ	_	5	amod	_	_
5	advancement	advancement	NN	NN	_	18	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	peak	peak	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	18	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	similar	similar	JJ	JJ	_	13	amod	_	_
12	circadian	circadian	JJ	JJ	_	13	amod	_	_
13	rhythm	rhythm	NN	NN	_	18	nsubjpass	_	_
14	of	of	IN	IN	_	16	case	_	_
15	hepatic	hepatic	JJ	JJ	_	16	amod	_	_
16	GR	gr	NN	NN	_	13	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	detected	detect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	rats	rat	NNS	NNS	_	18	nmod	_	_
21	reared	rear	VBN	VBN	_	20	acl	_	_
22	under	under	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	reversed	reverse	VBN	VBN	_	26	amod	_	_
25	lighting	lighting	NN	NN	_	26	compound	_	_
26	regimen	regimen	NNS	NNS	_	21	nmod	_	_
27	(	(	-LRB-	-LRB-	_	32	punct	_	_
28	12D	12d	NN	NN	_	30	compound	_	_
29	:	:	:	:	_	30	punct	_	_
30	12L	12l	NN	NN	_	32	dep	_	_
31	;	;	:	:	_	32	punct	_	_
32	lights	light	NNS	NNS	_	26	dep	_	_
33	on	on	IN	IN	_	32	advmod	_	_
34	between	between	IN	IN	_	38	case	_	_
35	18:30	18:30	CD	CD	_	38	nummod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	06:30	06:30	CD	CD	_	35	conj	_	_
38	h	h	NN	NN	_	32	dep	_	_
39	)	)	-RRB-	-RRB-	_	32	punct	_	_
40	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	leukocytes	leukocyte	NNS	NNS	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	peak	peak	JJ	JJ	_	7	amod	_	_
7	value	value	NN	NN	_	11	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GR	gr	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	parallel	parallel	VB	VB	_	11	xcomp	_	_
14	that	that	DT	DT	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	plasma	plasma	NN	NN	_	17	compound	_	_
17	cortisol	cortisol	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	22	case	_	_
19	high	high	JJ	JJ	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	low	low	JJ	JJ	_	19	conj	_	_
22	values	value	NNS	NNS	_	17	nmod	_	_
23	detected	detect	VBN	VBN	_	22	acl	_	_
24	at	at	IN	IN	_	26	case	_	_
25	04:00-08:00	04:00-08:00	CD	CD	_	26	nummod	_	_
26	h	h	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	23:00-24:00	23:00-24:00	CD	CD	_	29	nummod	_	_
29	h	h	NN	NN	_	26	conj	_	_
30	,	,	,	,	_	23	punct	_	_
31	respectively	respectively	RB	RB	_	23	advmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	16	nmod	_	_
3	suffering	suffer	VBG	VBG	_	2	acl	_	_
4	from	from	IN	IN	_	7	case	_	_
5	Cushing	cushing	NN	NN	_	7	nmod:poss	_	_
6	's	's	POS	POS	_	5	case	_	_
7	syndrome	syndrome	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	circadian	circadian	JJ	JJ	_	11	amod	_	_
11	rhythm	rhythm	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	plasma	plasma	NN	NN	_	14	compound	_	_
14	cortisol	cortisol	NN	NN	_	11	nmod	_	_
15	either	either	CC	CC	_	16	cc:preconj	_	_
16	disappeared	disappear	VBD	VBD	_	0	root	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	inverted	invert	VBN	VBN	_	16	conj	_	_
20	while	while	IN	IN	_	27	mark	_	_
21	that	that	DT	DT	_	27	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	GR	gr	NN	NN	_	21	nmod	_	_
24	did	do	VBD	VBD	_	27	aux	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	significantly	significantly	RB	RB	_	27	advmod	_	_
27	deviate	deviate	VB	VB	_	16	advcl	_	_
28	from	from	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	normal	normal	JJ	JJ	_	31	amod	_	_
31	subjects	subject	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	apoplexic	apoplexic	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	25	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	lesions	lesion	NNS	NNS	_	3	nmod	_	_
6	localized	localized	JJ	JJ	_	5	dep	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	base	base	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	brain	brain	NN	NN	_	9	nmod	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	indicated	indicate	VBN	VBN	_	6	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	computerized	computerize	VBN	VBN	_	17	amod	_	_
17	tomography	tomography	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	25	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	diurnal	diurnal	JJ	JJ	_	21	amod	_	_
21	variation	variation	NN	NN	_	25	nsubjpass	_	_
22	of	of	IN	IN	_	23	case	_	_
23	GR	gr	NN	NN	_	21	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	abolished	abolish	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	Conversely	conversely	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	diurnal	diurnal	JJ	JJ	_	4	amod	_	_
4	rhythmicity	rhythmicity	NN	NN	_	5	nsubj	_	_
5	persisted	persist	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	apoplexy	apoplexy	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	whose	whose	WP$	WP$	_	10	nmod:poss	_	_
10	lesions	lesion	NNS	NNS	_	15	nsubj	_	_
11	were	be	VBD	VBD	_	15	cop	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	cerebral	cerebral	JJ	JJ	_	15	amod	_	_
15	cortex	cortex	NN	NN	_	8	acl:relcl	_	_
16	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	postulated	postulate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	circadian	circadian	JJ	JJ	_	8	amod	_	_
8	modification	modification	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	GR	gr	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	independent	independent	JJ	JJ	_	4	ccomp	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	diurnal	diurnal	JJ	JJ	_	16	amod	_	_
16	fluctuations	fluctuation	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	plasma	plasma	NN	NN	_	20	compound	_	_
19	cortisol	cortisol	NN	NN	_	20	compound	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	or	or	CC	CC	_	16	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	circadian	circadian	JJ	JJ	_	24	amod	_	_
24	variations	variation	NNS	NNS	_	16	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	environmental	environmental	JJ	JJ	_	27	amod	_	_
27	lighting	lighting	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	12	cc	_	_
29	that	that	IN	IN	_	34	mark	_	_
30	the	the	DT	DT	_	31	det	_	_
31	rhythmicity	rhythmicity	NN	NN	_	34	nsubjpass	_	_
32	might	might	MD	MD	_	34	aux	_	_
33	be	be	VB	VB	_	34	auxpass	_	_
34	regulated	regulate	VBN	VBN	_	12	conj	_	_
35	by	by	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	'	'	``	``	_	39	punct	_	_
38	circadian	circadian	JJ	JJ	_	39	amod	_	_
39	pacemaker	pacemaker	NN	NN	_	34	nmod	_	_
40	'	'	''	''	_	39	punct	_	_
41	located	located	JJ	JJ	_	39	amod	_	_
42	in	in	IN	IN	_	46	case	_	_
43	the	the	DT	DT	_	46	det	_	_
44	human	human	JJ	JJ	_	46	amod	_	_
45	basal	basal	JJ	JJ	_	46	amod	_	_
46	brain	brain	NN	NN	_	41	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	diurnal	diurnal	JJ	JJ	_	3	amod	_	_
3	variations	variation	NNS	NNS	_	7	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	GR	gr	NN	NN	_	3	nmod	_	_
6	might	might	MD	MD	_	7	aux	_	_
7	serve	serve	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	coordinate	coordinate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	reactivity	reactivity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	target	target	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	cortisol	cortisol	NN	NN	_	11	nmod	_	_
18	because	because	IN	IN	_	41	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	diurnal	diurnal	JJ	JJ	_	21	amod	_	_
21	rhythms	rhythm	NNS	NNS	_	41	nsubjpass	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	GR-mediated	gr-mediated	JJ	JJ	_	25	amod	_	_
25	response	response	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	the	the	DT	DT	_	29	det	_	_
28	fractional	fractional	JJ	JJ	_	29	amod	_	_
29	inhibition	inhibition	NN	NN	_	21	appos	_	_
30	of	of	IN	IN	_	33	case	_	_
31	chemotactic	chemotactic	JJ	JJ	_	33	amod	_	_
32	migration	migration	NN	NN	_	33	compound	_	_
33	rate	rate	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	polymorphonuclear	polymorphonuclear	JJ	JJ	_	36	amod	_	_
36	leukocytes	leukocyte	NNS	NNS	_	33	nmod	_	_
37	by	by	IN	IN	_	38	case	_	_
38	cortisol	cortisol	NN	NN	_	29	nmod	_	_
39	,	,	,	,	_	21	punct	_	_
40	were	be	VBD	VBD	_	41	auxpass	_	_
41	found	find	VBN	VBN	_	9	advcl	_	_
42	to	to	TO	TO	_	44	mark	_	_
43	be	be	VB	VB	_	44	cop	_	_
44	synchronous	synchronous	JJ	JJ	_	41	xcomp	_	_
45	with	with	IN	IN	_	46	case	_	_
46	those	those	DT	DT	_	44	nmod	_	_
47	of	of	IN	IN	_	48	case	_	_
48	GR	gr	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	7	punct	_	_

1	Multiple	multiple	JJ	JJ	_	3	amod	_	_
2	Oct2	oct2	NN	NN	_	3	compound	_	_
3	isoforms	isoform	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	generated	generate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	alternative	alternative	JJ	JJ	_	8	amod	_	_
8	splicing	splicing	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Oct2	oct2	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	cognate	cognate	JJ	JJ	_	13	amod	_	_
11	octamer	octamer	NN	NN	_	13	compound	_	_
12	motif	motif	NN	NN	_	13	compound	_	_
13	ATGCAAAT	atgcaaat	NN	NN	_	2	nmod	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	critical	critical	JJ	JJ	_	17	amod	_	_
17	determinant	determinant	NN	NN	_	0	root	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	lymphoid-specific	lymphoid-specific	JJ	JJ	_	21	amod	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	Ectopic	ectopic	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cloned	clone	VBN	VBN	_	6	amod	_	_
5	Oct2	oct2	NN	NN	_	6	compound	_	_
6	cDNA	cdna	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	8	xcomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	reconstitute	reconstitute	VB	VB	_	11	xcomp	_	_
14	at	at	IN	IN	_	15	case	_	_
15	least	least	JJS	JJS	_	16	nmod:npmod	_	_
16	some	some	DT	DT	_	17	nummod	_	_
17	aspects	aspect	NNS	NNS	_	13	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	regulation	regulation	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	non-lymphoid	non-lymphoid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	isolation	isolation	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	characterization	characterization	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	multiple	multiple	JJ	JJ	_	9	amod	_	_
9	cDNAs	cdna	NNS	NNS	_	4	nmod	_	_
10	encoding	encode	VBG	VBG	_	9	acl	_	_
11	mouse	mouse	NN	NN	_	12	compound	_	_
12	Oct2	oct2	NN	NN	_	10	dobj	_	_
13	from	from	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	mature	mature	JJ	JJ	_	17	amod	_	_
16	B-cell	b-cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	show	show	VBP	VBP	_	2	conj	_	_
21	that	that	IN	IN	_	31	mark	_	_
22	a	a	DT	DT	_	23	det	_	_
23	variety	variety	NN	NN	_	31	nsubjpass	_	_
24	of	of	IN	IN	_	25	case	_	_
25	isoforms	isoform	NNS	NNS	_	23	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	this	this	DT	DT	_	29	det	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	25	nmod	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	generated	generate	VBN	VBN	_	20	ccomp	_	_
32	from	from	IN	IN	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	single	single	JJ	JJ	_	35	amod	_	_
35	gene	gene	NN	NN	_	31	nmod	_	_
36	by	by	IN	IN	_	40	case	_	_
37	an	a	DT	DT	_	40	det	_	_
38	alternative	alternative	JJ	JJ	_	40	amod	_	_
39	splicing	splicing	NN	NN	_	40	compound	_	_
40	mechanism	mechanism	NN	NN	_	31	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	All	all	PDT	PDT	_	3	det:predet	_	_
2	the	the	DT	DT	_	3	det	_	_
3	isoforms	isoform	NNS	NNS	_	4	nsubj	_	_
4	retain	retain	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	previously	previously	RB	RB	_	7	advmod	_	_
7	characterized	characterize	VBN	VBN	_	8	amod	_	_
8	POU-domain	pou-domain	NN	NN	_	4	dobj	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	are	be	VBP	VBP	_	12	cop	_	_
11	therefore	therefore	RB	RB	_	12	advmod	_	_
12	able	able	JJ	JJ	_	4	conj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	bind	bind	VB	VB	_	12	xcomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	octamer	octamer	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	amounts	amount	NNS	NNS	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	various	various	JJ	JJ	_	6	amod	_	_
6	isoforms	isoform	NNS	NNS	_	2	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	present	present	JJ	JJ	_	0	root	_	_
9	within	within	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	same	same	JJ	JJ	_	12	amod	_	_
12	B-cell	b-cell	NN	NN	_	8	nmod	_	_
13	regardless	regardless	RB	RB	_	8	advmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	developmental	developmental	JJ	JJ	_	17	amod	_	_
17	stage	stage	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	B-cell	b-cell	NN	NN	_	20	compound	_	_
20	differentiation	differentiation	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	8	cc	_	_
22	at	at	IN	IN	_	23	case	_	_
23	least	least	JJS	JJS	_	24	advmod	_	_
24	some	some	DT	DT	_	29	nsubjpass	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	isoforms	isoform	NNS	NNS	_	24	nmod	_	_
28	are	be	VBP	VBP	_	29	auxpass	_	_
29	conserved	conserve	VBN	VBN	_	8	conj	_	_
30	between	between	IN	IN	_	31	case	_	_
31	mouse	mouse	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	humans	human	NNS	NNS	_	31	conj	_	_
34	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	cotransfection	cotransfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	all	all	PDT	PDT	_	9	det:predet	_	_
8	the	the	DT	DT	_	9	det	_	_
9	isoforms	isoform	NNS	NNS	_	11	nsubj	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	able	able	JJ	JJ	_	5	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	activate	activate	VB	VB	_	11	xcomp	_	_
14	an	a	DT	DT	_	15	det	_	_
15	octamer	octamer	NN	NN	_	13	dobj	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	fibroblasts	fibroblast	NNS	NNS	_	16	nmod	_	_
21	revealing	reveal	VBG	VBG	_	13	xcomp	_	_
22	an	a	DT	DT	_	25	det	_	_
23	unexpected	unexpected	JJ	JJ	_	25	amod	_	_
24	functional	functional	JJ	JJ	_	25	amod	_	_
25	redundancy	redundancy	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	5	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	one	one	CD	CD	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	isoforms	isoform	NNS	NNS	_	6	nmod	_	_
10	encodes	encode	VBZ	VBZ	_	4	ccomp	_	_
11	the	the	DT	DT	_	16	det	_	_
12	previously	previously	RB	RB	_	13	advmod	_	_
13	described	describe	VBN	VBN	_	16	amod	_	_
14	lymphoid-specific	lymphoid-specific	JJ	JJ	_	16	amod	_	_
15	Oct2B	oct2b	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	10	dobj	_	_
17	which	which	WDT	WDT	_	20	nsubjpass	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	suggested	suggest	VBN	VBN	_	16	acl:relcl	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	involved	involve	VBN	VBN	_	20	xcomp	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	function	function	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	octamer	octamer	NN	NN	_	30	compound	_	_
30	motif	motif	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	41	case	_	_
32	the	the	DT	DT	_	41	dep	_	_
33	context	context	NN	NN	_	41	dep	_	_
34	of	of	IN	IN	_	41	case	_	_
35	the	the	DT	DT	_	41	det	_	_
36	immunoglobulin	immunoglobulin	NN	NN	_	37	compound	_	_
37	heavy-chain	heavy-chain	NN	NN	_	41	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	IgH	igh	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	enhancer	enhancer	NN	NN	_	23	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	Purification	purification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	TCF-1	tcf-1	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	T-cell-specific	t-cell-specific	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	appos	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	activates	activate	VBZ	VBZ	_	9	acl:relcl	_	_
12	the	the	DT	DT	_	18	det	_	_
13	T-cell	t-cell	NN	NN	_	18	compound	_	_
14	receptor	receptor	NN	NN	_	18	compound	_	_
15	C	c	NN	NN	_	18	compound	_	_
16	alpha	alpha	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	11	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	context-dependent	context-dependent	JJ	JJ	_	22	amod	_	_
22	manner	manner	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	differentiation	differentiation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	into	into	IN	IN	_	9	case	_	_
7	functionally	functionally	RB	RB	_	8	advmod	_	_
8	diverse	diverse	JJ	JJ	_	9	amod	_	_
9	subpopulations	subpopulation	NNS	NNS	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	controlled	control	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	part	part	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	by	by	IN	IN	_	17	case	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	silencing	silencing	NN	NN	_	17	conj	_	_
20	;	;	:	:	_	11	punct	_	_
21	however	however	RB	RB	_	25	advmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	little	little	JJ	JJ	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	known	know	VBN	VBN	_	11	parataxis	_	_
26	in	in	IN	IN	_	27	case	_	_
27	detail	detail	NN	NN	_	25	nmod	_	_
28	about	about	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	proteins	protein	NNS	NNS	_	25	nmod	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	influence	influence	VBP	VBP	_	30	acl:relcl	_	_
33	this	this	DT	DT	_	35	det	_	_
34	developmental	developmental	JJ	JJ	_	35	amod	_	_
35	process	process	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	purified	purify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	new	new	JJ	JJ	_	7	amod	_	_
6	T-cell-specific	t-cell-specific	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	TCF-1	tcf-1	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	appos	_	_
11	,	,	,	,	_	10	punct	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	implicated	implicate	VBN	VBN	_	10	acl:relcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	genes	gene	NNS	NNS	_	17	nmod	_	_
20	encoding	encode	VBG	VBG	_	19	acl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	major	major	JJ	JJ	_	23	amod	_	_
23	component	component	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TCR	tcr	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	3	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	18	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	originally	originally	RB	RB	_	5	advmod	_	_
5	identified	identify	VBN	VBN	_	2	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	purified	purify	VBN	VBN	_	5	conj	_	_
8	through	through	IN	IN	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	binding	bind	VBG	VBG	_	11	amod	_	_
11	sites	site	NNS	NNS	_	7	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	bind	bind	VB	VB	_	18	xcomp	_	_
21	to	to	TO	TO	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	TCR	tcr	NN	NN	_	25	compound	_	_
24	alpha	alpha	NN	NN	_	25	compound	_	_
25	enhancer	enhancer	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	to	to	TO	TO	_	28	case	_	_
28	promoters	promoter	NNS	NNS	_	25	conj	_	_
29	for	for	IN	IN	_	31	case	_	_
30	several	several	JJ	JJ	_	31	amod	_	_
31	genes	gene	NNS	NNS	_	28	nmod	_	_
32	expressed	express	VBN	VBN	_	31	acl	_	_
33	at	at	IN	IN	_	36	case	_	_
34	significantly	significantly	RB	RB	_	35	advmod	_	_
35	earlier	earlier	JJR	JJR	_	36	amod	_	_
36	stages	stage	NNS	NNS	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	T-cell	t-cell	NN	NN	_	39	compound	_	_
39	development	development	NN	NN	_	36	nmod	_	_
40	than	than	IN	IN	_	44	case	_	_
41	the	the	DT	DT	_	44	det	_	_
42	TCR	tcr	NN	NN	_	44	compound	_	_
43	alpha	alpha	NN	NN	_	44	compound	_	_
44	gene	gene	NN	NN	_	36	nmod	_	_
45	(	(	-LRB-	-LRB-	_	48	punct	_	_
46	e.g.	e.g.	FW	FW	_	48	dep	_	_
47	,	,	,	,	_	48	punct	_	_
48	p56lck	p56lck	NN	NN	_	44	dep	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	CD3	cd3	NN	NN	_	51	compound	_	_
51	delta	delta	NN	NN	_	48	conj	_	_
52	)	)	-RRB-	-RRB-	_	48	punct	_	_
53	.	.	.	.	_	18	punct	_	_

1	Sequences	sequence	NNS	NNS	_	14	nsubjpass	_	_
2	related	related	JJ	JJ	_	1	amod	_	_
3	to	to	TO	TO	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	TCF-1	tcf-1	NN	NN	_	8	compound	_	_
6	alpha	alpha	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	motif	motif	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	5'-GGCACCCTTTGA-3'	5'-ggcaccctttga-3'	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	TCR	tcr	NN	NN	_	19	compound	_	_
19	delta	delta	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	and	and	CC	CC	_	24	cc	_	_
22	possibly	possibly	RB	RB	_	24	dep	_	_
23	TCR	tcr	NN	NN	_	24	compound	_	_
24	beta	beta	NN	NN	_	19	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	enhancers	enhancer	NNS	NNS	_	19	dep	_	_
27	.	.	.	.	_	14	punct	_	_

1	Southwestern	southwestern	JJ	JJ	_	13	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	gel	gel	NN	NN	_	4	compound	_	_
4	renaturation	renaturation	NN	NN	_	1	conj	_	_
5	experiments	experiment	NNS	NNS	_	1	dep	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	use	use	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	purified	purify	VBN	VBN	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	fractions	fraction	NNS	NNS	_	8	nmod	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	TCF-1	tcf-1	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	derived	derive	VBN	VBN	_	13	ccomp	_	_
20	from	from	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	family	family	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	57-	57-	CD	CD	_	27	nummod	_	_
25	to	to	TO	TO	_	27	dep	_	_
26	53-kD	53-kd	JJ	JJ	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	22	nmod	_	_
28	that	that	WDT	WDT	_	31	nsubjpass	_	_
29	are	be	VBP	VBP	_	31	auxpass	_	_
30	abundantly	abundantly	RB	RB	_	31	advmod	_	_
31	expressed	express	VBN	VBN	_	27	acl:relcl	_	_
32	in	in	IN	IN	_	33	case	_	_
33	mature	mature	JJ	JJ	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	immature	immature	JJ	JJ	_	33	conj	_	_
36	T-cell	t-cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	33	dep	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	Jurkat	jurkat	NN	NN	_	33	dep	_	_
40	,	,	,	,	_	39	punct	_	_
41	CCRF-CEM	ccrf-cem	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	39	punct	_	_
43	and	and	CC	CC	_	33	cc	_	_
44	not	not	RB	RB	_	48	neg	_	_
45	in	in	IN	IN	_	48	case	_	_
46	mature	mature	JJ	JJ	_	48	amod	_	_
47	B	b	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	33	conj	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	JY	jy	NN	NN	_	48	dep	_	_
51	,	,	,	,	_	50	punct	_	_
52	Namalwa	namalwa	NN	NN	_	50	appos	_	_
53	)	)	-RRB-	-RRB-	_	50	punct	_	_
54	or	or	CC	CC	_	48	cc	_	_
55	nonlymphoid	nonlymphoid	JJ	JJ	_	60	amod	_	_
56	(	(	-LRB-	-LRB-	_	60	punct	_	_
57	HeLa	hela	NN	NN	_	60	compound	_	_
58	)	)	-RRB-	-RRB-	_	60	punct	_	_
59	cell	cell	NN	NN	_	60	compound	_	_
60	lines	line	NNS	NNS	_	48	conj	_	_
61	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	small	small	JJ	JJ	_	4	amod	_	_
3	95-bp	95-bp	JJ	JJ	_	2	dep	_	_
4	fragment	fragment	NN	NN	_	45	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	TCR	tcr	NN	NN	_	10	compound	_	_
8	alpha	alpha	NN	NN	_	10	compound	_	_
9	control	control	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	4	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	contains	contain	VBZ	VBZ	_	4	acl:relcl	_	_
13	the	the	DT	DT	_	17	det	_	_
14	TCF-1	tcf-1	NN	NN	_	17	compound	_	_
15	alpha	alpha	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	12	dobj	_	_
18	juxtaposed	juxtapose	VBD	VBD	_	17	acl	_	_
19	between	between	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	cAMP-response	camp-response	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	the	the	DT	DT	_	25	det	_	_
25	CRE	cre	NN	NN	_	22	dep	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	alpha	alpha	NN	NN	_	30	compound	_	_
29	1	1	CD	CD	_	30	nummod	_	_
30	motif	motif	NN	NN	_	25	conj	_	_
31	)	)	-RRB-	-RRB-	_	25	punct	_	_
32	and	and	CC	CC	_	22	cc	_	_
33	the	the	DT	DT	_	35	det	_	_
34	binding	bind	VBG	VBG	_	35	amod	_	_
35	site	site	NN	NN	_	22	conj	_	_
36	for	for	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	distinct	distinct	JJ	JJ	_	40	amod	_	_
39	lymphoid-specific	lymphoid-specific	JJ	JJ	_	40	amod	_	_
40	protein	protein	NN	NN	_	35	nmod	_	_
41	(	(	-LRB-	-LRB-	_	43	punct	_	_
42	TCF-2	tcf-2	NN	NN	_	43	compound	_	_
43	alpha	alpha	NN	NN	_	40	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	behaved	behave	VBD	VBD	_	0	root	_	_
46	as	as	IN	IN	_	50	case	_	_
47	a	a	DT	DT	_	50	det	_	_
48	potent	potent	JJ	JJ	_	50	amod	_	_
49	T-cell-specific	t-cell-specific	JJ	JJ	_	50	amod	_	_
50	enhancer	enhancer	NN	NN	_	45	nmod	_	_
51	in	in	FW	FW	_	52	compound	_	_
52	vivo	vivo	FW	FW	_	45	advmod	_	_
53	.	.	.	.	_	45	punct	_	_

1	Tandem	tandem	JJ	JJ	_	2	amod	_	_
2	copies	copy	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	enhancer	enhancer	NN	NN	_	2	nmod	_	_
6	functioned	function	VBD	VBD	_	0	root	_	_
7	synergistically	synergistically	RB	RB	_	6	advmod	_	_
8	in	in	IN	IN	_	14	case	_	_
9	mature	mature	JJ	JJ	_	14	amod	_	_
10	(	(	-LRB-	-LRB-	_	14	punct	_	_
11	Jurkat	jurkat	NN	NN	_	14	compound	_	_
12	)	)	-RRB-	-RRB-	_	14	punct	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	6	nmod	_	_
15	as	as	RB	RB	_	14	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	resting	rest	VBG	VBG	_	14	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	activated	activate	VBN	VBN	_	18	conj	_	_
21	immature	immature	JJ	JJ	_	26	amod	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	CCRF-CEM	ccrf-cem	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	18	dep	_	_
27	.	.	.	.	_	6	punct	_	_

1	Mutation	mutation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	TCF-1	tcf-1	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	1	nmod	_	_
8	diminished	diminish	VBD	VBD	_	0	root	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	disrupted	disrupt	VBD	VBD	_	8	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	synergism	synergism	NN	NN	_	12	dobj	_	_
15	observed	observe	VBN	VBN	_	14	acl	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vivo	vivo	FW	FW	_	15	advmod	_	_
18	between	between	IN	IN	_	21	case	_	_
19	tandem	tandem	JJ	JJ	_	21	amod	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	repeats	repeat	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	TCF-1	tcf-1	NN	NN	_	5	compound	_	_
3	alpha	alpha	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	13	case	_	_
10	TCR	tcr	NN	NN	_	13	compound	_	_
11	alpha	alpha	NN	NN	_	13	compound	_	_
12	enhancer	enhancer	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	transcriptionally	transcriptionally	RB	RB	_	16	advmod	_	_
16	active	active	JJ	JJ	_	17	amod	_	_
17	extracts	extract	NNS	NNS	_	13	nmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	Jurkat	jurkat	NN	NN	_	17	nmod	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	19	cc	_	_
22	HeLa	hela	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	conj	_	_
24	,	,	,	,	_	8	punct	_	_
25	confirming	confirm	VBG	VBG	_	8	advcl	_	_
26	that	that	IN	IN	_	33	mark	_	_
27	TCF-1	tcf-1	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	33	nsubj	_	_
29	is	be	VBZ	VBZ	_	33	cop	_	_
30	a	a	DT	DT	_	33	det	_	_
31	T-cell-specific	t-cell-specific	JJ	JJ	_	33	amod	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factor	factor	NN	NN	_	25	ccomp	_	_
34	.	.	.	.	_	8	punct	_	_

1	Curiously	curiously	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	TCF-1	tcf-1	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	inactive	inactive	JJ	JJ	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	removed	remove	VBN	VBN	_	9	advcl	_	_
14	from	from	IN	IN	_	17	case	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	neighboring	neighboring	JJ	JJ	_	17	amod	_	_
17	elements	element	NNS	NNS	_	13	nmod	_	_
18	on	on	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	TCR	tcr	NN	NN	_	22	compound	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	enhancer	enhancer	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	positioned	positioned	JJ	JJ	_	13	conj	_	_
25	in	in	IN	IN	_	26	case	_	_
26	one	one	CD	CD	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	more	more	JJR	JJR	_	26	conj	_	_
29	copies	copy	NNS	NNS	_	26	dep	_	_
30	upstream	upstream	RB	RB	_	26	advmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	heterologous	heterologous	JJ	JJ	_	34	amod	_	_
34	promoter	promoter	NN	NN	_	26	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	TCF-1	tcf-1	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	5	nmod	_	_
9	appears	appear	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	depend	depend	VB	VB	_	9	xcomp	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	dep	_	_
14	TCF-2	tcf-2	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	conj	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CREB	creb	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	15	dep	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	the	the	DT	DT	_	27	det	_	_
27	context	context	NN	NN	_	15	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
30	binding	bind	VBG	VBG	_	31	amod	_	_
31	site	site	NN	NN	_	27	nmod	_	_
32	within	within	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	TCR	tcr	NN	NN	_	36	compound	_	_
35	alpha	alpha	NN	NN	_	36	compound	_	_
36	enhancer	enhancer	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	Murine	murine	JJ	JJ	_	6	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	human	human	JJ	JJ	_	1	conj	_	_
4	T-lymphocyte	t-lymphocyte	NN	NN	_	6	compound	_	_
5	GATA-3	gata-3	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	7	nsubj	_	_
7	mediate	mediate	VBP	VBP	_	0	root	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	through	through	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	cis-regulatory	cis-regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	7	nmod	_	_
13	within	within	IN	IN	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	human	human	JJ	JJ	_	20	amod	_	_
16	T-cell	t-cell	NN	NN	_	20	compound	_	_
17	receptor	receptor	NN	NN	_	20	compound	_	_
18	delta	delta	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	enhancer	enhancer	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	family	family	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activators	activator	NNS	NNS	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	9	aux	_	_
7	recently	recently	RB	RB	_	9	advmod	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	identified	identify	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	chickens	chicken	NNS	NNS	_	9	nmod	_	_
12	;	;	:	:	_	9	punct	_	_
13	these	these	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activators	activator	NNS	NNS	_	16	nsubj	_	_
16	recognize	recognize	VBP	VBP	_	9	parataxis	_	_
17	a	a	DT	DT	_	20	det	_	_
18	common	common	JJ	JJ	_	20	amod	_	_
19	consensus	consensus	NN	NN	_	20	compound	_	_
20	motif	motif	NN	NN	_	16	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	WGATAR	wgatar	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	through	through	IN	IN	_	31	case	_	_
25	a	a	DT	DT	_	31	det	_	_
26	conserved	conserve	VBN	VBN	_	31	amod	_	_
27	C4	c4	NN	NN	_	31	compound	_	_
28	zinc	zinc	NN	NN	_	31	compound	_	_
29	finger	finger	NN	NN	_	31	compound	_	_
30	DNA-binding	dna-binding	JJ	JJ	_	31	amod	_	_
31	domain	domain	NN	NN	_	16	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	One	one	CD	CD	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	members	member	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	this	this	DT	DT	_	8	det	_	_
7	multigene	multigene	JJ	JJ	_	8	amod	_	_
8	family	family	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	cGATA-3	cgata-3	NN	NN	_	1	appos	_	_
11	,	,	,	,	_	1	punct	_	_
12	is	be	VBZ	VBZ	_	15	auxpass	_	_
13	most	most	RBS	RBS	_	14	advmod	_	_
14	abundantly	abundantly	RB	RB	_	15	advmod	_	_
15	expressed	express	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	T-lymphocyte	t-lymphocyte	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lineage	lineage	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	murine	murine	JJ	JJ	_	3	conj	_	_
6	GATA-3	gata-3	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	1	nmod	_	_
8	shows	show	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	striking	striking	JJ	JJ	_	11	amod	_	_
11	degree	degree	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	amino	amino	NN	NN	_	16	compound	_	_
14	acid	acid	NN	NN	_	16	compound	_	_
15	sequence	sequence	NN	NN	_	16	compound	_	_
16	identity	identity	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	similar	similar	JJ	JJ	_	19	amod	_	_
19	patterns	pattern	NNS	NNS	_	11	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	tissue	tissue	NN	NN	_	22	compound	_	_
22	specificity	specificity	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	expression	expression	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	these	these	DT	DT	_	28	det	_	_
27	three	three	CD	CD	_	28	nummod	_	_
28	organisms	organism	NNS	NNS	_	11	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	murine	murine	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	human	human	JJ	JJ	_	2	conj	_	_
5	factors	factor	NNS	NNS	_	8	nsubjpass	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	abundantly	abundantly	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	murine	murine	JJ	JJ	_	13	conj	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	activate	activate	VB	VB	_	8	conj	_	_
21	transcription	transcription	NN	NN	_	20	dobj	_	_
22	through	through	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	tissue-specific	tissue-specific	JJ	JJ	_	26	amod	_	_
25	GATA-binding	gata-binding	JJ	JJ	_	26	amod	_	_
26	site	site	NN	NN	_	20	nmod	_	_
27	identified	identify	VBN	VBN	_	26	acl	_	_
28	within	within	IN	IN	_	35	case	_	_
29	the	the	DT	DT	_	35	det	_	_
30	human	human	JJ	JJ	_	35	amod	_	_
31	T-cell	t-cell	NN	NN	_	35	compound	_	_
32	receptor	receptor	NN	NN	_	35	compound	_	_
33	delta	delta	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	enhancer	enhancer	NN	NN	_	27	nmod	_	_
36	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	infer	infer	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	9	det	_	_
5	murine	murine	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	human	human	JJ	JJ	_	5	conj	_	_
8	GATA-3	gata-3	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	10	nsubj	_	_
10	play	play	VBP	VBP	_	2	ccomp	_	_
11	a	a	DT	DT	_	16	det	_	_
12	central	central	JJ	JJ	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	highly	highly	RB	RB	_	15	advmod	_	_
15	conserved	conserve	VBN	VBN	_	12	conj	_	_
16	role	role	NN	NN	_	10	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	vertebrate	vertebrate	NN	NN	_	21	compound	_	_
19	T-cell-specific	t-cell-specific	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	regulation	regulation	NN	NN	_	10	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Processing	processing	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	precursor	precursor	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	protease	protease	NN	NN	_	1	nmod	_	_
12	during	during	IN	IN	_	14	case	_	_
13	acute	acute	JJ	JJ	_	14	amod	_	_
14	infection	infection	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Transcription	transcription	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	11	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type-1	type-1	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HIV-1	hiv-1	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	genome	genome	NN	NN	_	1	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	part	part	NN	NN	_	18	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	factors	factor	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	stimulated	stimulate	VBN	VBN	_	13	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	latently	latently	RB	RB	_	26	advmod	_	_
26	infected	infected	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	T-cell	t-cell	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	correlates	correlate	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	7	nmod	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	12	acl:relcl	_	_
15	to	to	TO	TO	_	18	case	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	adjacent	adjacent	JJ	JJ	_	18	amod	_	_
18	sites	site	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	HIV-1	hiv-1	NN	NN	_	24	compound	_	_
22	long	long	JJ	JJ	_	24	amod	_	_
23	terminal	terminal	JJ	JJ	_	24	amod	_	_
24	repeat	repeat	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	3	nsubj	_	_
3	consists	consist	VBZ	VBZ	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	subunits	subunit	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	relative	relative	JJ	JJ	_	11	amod	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	mass	mass	NN	NN	_	7	nmod	_	_
12	50,000	50,000	CD	CD	_	11	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	50K	50k	CD	CD	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	associated	associate	VBN	VBN	_	7	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	two	two	CD	CD	_	20	nummod	_	_
19	65K	65k	CD	CD	_	20	nummod	_	_
20	subunits	subunit	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	located	located	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	nucleus	nucleus	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	mature	mature	JJ	JJ	_	10	amod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	but	but	CC	CC	_	3	cc	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	present	present	JJ	JJ	_	3	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	14	nmod	_	_
19	as	as	IN	IN	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	inactive	inactive	JJ	JJ	_	23	amod	_	_
22	cytoplasmic	cytoplasmic	JJ	JJ	_	23	amod	_	_
23	complex	complex	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	External	external	JJ	JJ	_	2	amod	_	_
2	stimuli	stimulus	NNS	NNS	_	11	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	including	include	VBG	VBG	_	5	case	_	_
5	those	those	DT	DT	_	2	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	activate	activate	VBP	VBP	_	5	acl:relcl	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	7	dobj	_	_
10	,	,	,	,	_	2	punct	_	_
11	result	result	VBP	VBP	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	translocation	translocation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	active	active	JJ	JJ	_	18	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cloning	cloning	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	complementary	complementary	JJ	JJ	_	6	amod	_	_
6	DNA	dna	NN	NN	_	2	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	50K	50k	CD	CD	_	10	nummod	_	_
10	subunit	subunit	NN	NN	_	6	nmod	_	_
11	helped	help	VBD	VBD	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	identify	identify	VB	VB	_	11	xcomp	_	_
14	an	a	DT	DT	_	18	det	_	_
15	exclusively	exclusively	RB	RB	_	16	advmod	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
17	105K	105k	CD	CD	_	18	nummod	_	_
18	precursor	precursor	NN	NN	_	13	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	p105	p105	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	V.B.	V.B.	NNP	NNP	_	13	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	P.K.	P.K.	NNP	NNP	_	23	conj	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	A.I.	A.I.	NNP	NNP	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	manuscript	manuscript	NN	NN	_	23	dep	_	_
30	submitted	submit	VBN	VBN	_	29	acl	_	_
31	)	)	-RRB-	-RRB-	_	23	punct	_	_
32	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	active	active	JJ	JJ	_	6	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	might	might	MD	MD	_	11	aux	_	_
8	therefore	therefore	RB	RB	_	11	advmod	_	_
9	also	also	RB	RB	_	11	advmod	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	extent	extent	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	processing	processing	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	p105	p105	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Because	because	IN	IN	_	3	mark	_	_
2	HIV-1	hiv-1	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	12	advcl	_	_
4	active	active	JJ	JJ	_	6	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	efficient	efficient	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	tested	test	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effect	effect	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	14	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	processing	processing	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	105K	105k	CD	CD	_	25	nummod	_	_
25	precursor	precursor	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	protease	protease	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	process	process	VB	VB	_	2	ccomp	_	_
10	p105	p105	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	increases	increase	VBZ	VBZ	_	9	conj	_	_
13	levels	level	NNS	NNS	_	12	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	active	active	JJ	JJ	_	19	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	trans-activator	trans-activator	NN	NN	_	0	root	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	recognizes	recognize	VBZ	VBZ	_	4	acl:relcl	_	_
7	a	a	DT	DT	_	10	det	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	ester-inducible	ester-inducible	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	interleukin-2	interleukin-2	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	interleukin	interleukin	NN	NN	_	8	compound	_	_
3	2	2	CD	CD	_	8	nummod	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	IL-2	il-2	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	recognized	recognize	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	several	several	JJ	JJ	_	13	amod	_	_
13	cell-type-specific	cell-type-specific	JJ	JJ	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ubiquitous	ubiquitous	JJ	JJ	_	13	conj	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	regulators	regulator	NNS	NNS	_	13	dep	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	integrate	integrate	VBP	VBP	_	13	acl:relcl	_	_
20	information	information	NN	NN	_	19	dobj	_	_
21	transmitted	transmit	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	25	case	_	_
23	various	various	JJ	JJ	_	25	amod	_	_
24	signaling	signaling	NN	NN	_	25	compound	_	_
25	systems	system	NNS	NNS	_	21	nmod	_	_
26	leading	lead	VBG	VBG	_	20	acl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	production	production	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	10	punct	_	_

1	Using	use	VBG	VBG	_	18	advcl	_	_
2	a	a	DT	DT	_	3	det	_	_
3	combination	combination	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	transfection	transfection	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	protein-DNA	protein-dna	JJ	JJ	_	8	amod	_	_
8	binding	binding	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	in	in	FW	FW	_	13	amod	_	_
12	vitro	vitro	FW	FW	_	11	dep	_	_
13	transcription	transcription	NN	NN	_	5	conj	_	_
14	methods	method	NNS	NNS	_	5	dep	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	discovered	discover	VBN	VBN	_	0	root	_	_
19	the	the	DT	DT	_	23	det	_	_
20	novel	novel	JJ	JJ	_	23	amod	_	_
21	T-cell-specific	t-cell-specific	JJ	JJ	_	23	amod	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activator	activator	NN	NN	_	18	dobj	_	_
24	TCF-1	tcf-1	NN	NN	_	23	dep	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	for	for	IN	IN	_	28	case	_	_
27	T-Cell	t-cell	NN	NN	_	28	compound	_	_
28	Factor-1	factor-1	NN	NN	_	23	nmod	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	23	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	recognizes	recognize	VBZ	VBZ	_	23	acl:relcl	_	_
33	a	a	DT	DT	_	36	det	_	_
34	T-cell-specific	t-cell-specific	JJ	JJ	_	36	amod	_	_
35	response	response	NN	NN	_	36	compound	_	_
36	element	element	NN	NN	_	32	dobj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	TCE	tce	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	located	located	JJ	JJ	_	36	amod	_	_
41	within	within	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	IL-2	il-2	NN	NN	_	44	compound	_	_
44	promoter	promoter	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	TCE	tce	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	similar	similar	JJ	JJ	_	18	advcl	_	_
6	in	in	IN	IN	_	7	case	_	_
7	sequence	sequence	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	consensus	consensus	NN	NN	_	14	compound	_	_
11	NF	nf	NN	NN	_	14	compound	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	5	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	several	several	JJ	JJ	_	17	amod	_	_
17	criteria	criterion	NNS	NNS	_	18	nsubj	_	_
18	indicate	indicate	VBP	VBP	_	0	root	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	TCF-1	tcf-1	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	distinct	distinct	JJ	JJ	_	18	ccomp	_	_
23	from	from	IN	IN	_	26	case	_	_
24	NF	nf	NN	NN	_	26	compound	_	_
25	kappa	kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	like	like	IN	IN	_	6	case	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	TCF-1	tcf-1	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	phorbol	phorbol	NN	NN	_	14	compound	_	_
14	esters	ester	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	activators	activator	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	Vitamin	vitamin	NN	NN	_	4	compound	_	_
2	D	d	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	requirements	requirement	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	characterization	characterization	NN	NN	_	2	conj	_	_
5	by	by	IN	IN	_	7	case	_	_
6	western	western	NN	NN	_	7	compound	_	_
7	blots	blot	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	sequencing	sequencing	NN	NN	_	7	conj	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	signals	signal	NNS	NNS	_	31	nsubjpass	_	_
3	controlling	control	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	5	nmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	1	1	CD	CD	_	13	nummod	_	_
12	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	13	compound	_	_
13	D3	d3	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	relationship	relationship	NN	NN	_	2	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	classical	classical	JJ	JJ	_	29	amod	_	_
27	vitamin	vitamin	NN	NN	_	29	compound	_	_
28	D	d	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	20	nmod	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	examined	examine	VBN	VBN	_	0	root	_	_
32	.	.	.	.	_	31	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	12	nsubj	_	_
2	activated	activate	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	OKT3	okt3	NN	NN	_	6	compound	_	_
6	antibody	antibody	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	T-cell	t-cell	NN	NN	_	11	compound	_	_
10	antigen	antigen	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	6	nmod	_	_
12	expressed	express	VBD	VBD	_	0	root	_	_
13	fewer	fewer	JJR	JJR	_	15	amod	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	12	dobj	_	_
16	as	as	IN	IN	_	17	mark	_	_
17	compared	compare	VBN	VBN	_	12	advcl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
20	that	that	WDT	WDT	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	activated	activate	VBN	VBN	_	19	acl:relcl	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	polyclonal	polyclonal	JJ	JJ	_	27	amod	_	_
26	activator	activator	NN	NN	_	27	compound	_	_
27	phytohemagglutinin	phytohemagglutinin	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	PHA	pha	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	combination	combination	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	OKT3	okt3	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	phorbol	phorbol	NN	NN	_	9	compound	_	_
8	myristate	myristate	NN	NN	_	9	compound	_	_
9	acetate	acetate	NN	NN	_	5	conj	_	_
10	produced	produce	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	12	det	_	_
12	concentration	concentration	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	12	nmod	_	_
16	similar	similar	JJ	JJ	_	12	amod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	PHA-activated	pha-activated	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	receptor	receptor	NN	NN	_	12	nsubj	_	_
3	from	from	IN	IN	_	11	case	_	_
4	OKT3	okt3	NN	NN	_	11	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	OKT3	okt3	NN	NN	_	10	dep	_	_
7	+	+	CC	CC	_	10	cc	_	_
8	phorbol	phorbol	NN	NN	_	10	conj	_	_
9	myristate	myristate	NN	NN	_	10	dep	_	_
10	acetate-activated	acetate-activated	JJ	JJ	_	4	conj	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
12	exhibited	exhibit	VBD	VBD	_	0	root	_	_
13	decreased	decrease	VBN	VBN	_	14	amod	_	_
14	binding	binding	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	DNA-cellulose	dna-cellulose	NN	NN	_	14	nmod	_	_
17	compared	compare	VBN	VBN	_	12	dep	_	_
18	to	to	TO	TO	_	20	case	_	_
19	PHA-activated	pha-activated	JJ	JJ	_	20	amod	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	32	nmod	_	_
3	activated	activate	VBN	VBN	_	2	acl	_	_
4	either	either	CC	CC	_	6	dep	_	_
5	by	by	IN	IN	_	6	case	_	_
6	PHA	pha	NN	NN	_	3	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	OKT3	okt3	NN	NN	_	6	conj	_	_
9	(	(	-LRB-	-LRB-	_	2	punct	_	_
10	but	but	CC	CC	_	2	cc	_	_
11	not	not	RB	RB	_	14	neg	_	_
12	in	in	IN	IN	_	14	case	_	_
13	resting	rest	VBG	VBG	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	2	conj	_	_
15	)	)	-RRB-	-RRB-	_	2	punct	_	_
16	,	,	,	,	_	32	punct	_	_
17	a	a	DT	DT	_	19	det	_	_
18	50-kDa	50-kda	JJ	JJ	_	19	amod	_	_
19	species	species	NNS	NNS	_	32	nsubjpass	_	_
20	cross-reacting	cross-react	VBG	VBG	_	19	acl	_	_
21	with	with	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	monoclonal	monoclonal	JJ	JJ	_	24	amod	_	_
24	antibody	antibody	NN	NN	_	20	nmod	_	_
25	against	against	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	intestinal	intestinal	JJ	JJ	_	30	amod	_	_
28	vitamin	vitamin	NN	NN	_	30	compound	_	_
29	D	d	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	24	nmod	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	detected	detect	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	RNA	rna	NN	NN	_	8	nsubjpass	_	_
4	from	from	IN	IN	_	6	case	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	amplified	amplify	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	polymerase	polymerase	NN	NN	_	12	compound	_	_
11	chain	chain	NN	NN	_	12	compound	_	_
12	reaction	reaction	NN	NN	_	8	nmod	_	_
13	using	use	VBG	VBG	_	8	xcomp	_	_
14	oligonucleotide	oligonucleotide	NN	NN	_	15	compound	_	_
15	primers	primer	NNS	NNS	_	13	dobj	_	_
16	flanking	flank	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	22	det	_	_
18	196	196	CD	CD	_	22	nummod	_	_
19	base	base	NN	NN	_	22	compound	_	_
20	pair	pair	NN	NN	_	22	compound	_	_
21	long	long	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	16	dobj	_	_
23	encoding	encode	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	domain	domain	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	intestinal	intestinal	JJ	JJ	_	31	amod	_	_
31	receptor	receptor	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	amplified	amplify	VBN	VBN	_	3	amod	_	_
3	product	product	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	an	a	DT	DT	_	8	det	_	_
6	identical	identical	JJ	JJ	_	8	amod	_	_
7	nucleotide	nucleotide	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	4	dobj	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	intestinal	intestinal	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	expression	expression	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	triggered	trigger	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	18	case	_	_
15	distinct	distinct	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	contingent	contingent	JJ	JJ	_	15	conj	_	_
18	signals	signal	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	that	that	IN	IN	_	30	mark	_	_
22	the	the	DT	DT	_	23	det	_	_
23	protein	protein	NN	NN	_	30	nsubj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	mRNA	mrna	NN	NN	_	23	conj	_	_
27	encoding	encode	VBG	VBG	_	23	acl	_	_
28	it	it	PRP	PRP	_	27	dobj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	identical	identical	JJ	JJ	_	13	conj	_	_
31	to	to	TO	TO	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	classical	classical	JJ	JJ	_	36	amod	_	_
34	vitamin	vitamin	NN	NN	_	36	compound	_	_
35	D	d	NN	NN	_	36	compound	_	_
36	receptor	receptor	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Estrogen	estrogen	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	content	content	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	systemic	systemic	JJ	JJ	_	14	amod	_	_
13	lupus	lupus	NN	NN	_	14	compound	_	_
14	erythematosus	erythematosus	NN	NN	_	10	nmod	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	ER	er	NN	NN	_	2	compound	_	_
2	content	content	NN	NN	_	17	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
7	blood	blood	NN	NN	_	4	nmod	_	_
8	from	from	IN	IN	_	11	case	_	_
9	27	27	CD	CD	_	11	nummod	_	_
10	SLE	sle	NN	NN	_	11	compound	_	_
11	patients	patient	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	20	20	CD	CD	_	15	nummod	_	_
14	healthy	healthy	JJ	JJ	_	15	amod	_	_
15	controls	control	NNS	NNS	_	11	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	determined	determine	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	21	case	_	_
19	dextran-coated	dextran-coated	JJ	JJ	_	21	amod	_	_
20	charcoal	charcoal	NN	NN	_	21	compound	_	_
21	assay	assay	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	ER	er	NN	NN	_	2	compound	_	_
2	content	content	NN	NN	_	9	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	each	each	DT	DT	_	7	det	_	_
7	sample	sample	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	fmol/mg	fmol/mg	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	lymphocyte	lymphocyte	NN	NN	_	16	compound	_	_
15	cytosolic	cytosolic	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	fmol/micrograms	fmol/micrograms	NN	NN	_	12	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	lymphocyte	lymphocyte	NN	NN	_	21	compound	_	_
21	DNA	dna	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	was	be	VBD	VBD	_	3	ccomp	_	_
7	no	no	DT	DT	_	9	neg	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	difference	difference	NN	NN	_	6	nsubj	_	_
10	between	between	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	ER	er	NN	NN	_	13	compound	_	_
13	content	content	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	controls	control	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	that	that	DT	DT	_	13	conj	_	_
21	from	from	IN	IN	_	22	case	_	_
22	patients	patient	NNS	NNS	_	20	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	SLE	sle	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	But	but	CC	CC	_	31	cc	_	_
2	the	the	DT	DT	_	4	det	_	_
3	logarithmic	logarithmic	JJ	JJ	_	4	amod	_	_
4	mean	mean	NN	NN	_	31	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	ER	er	NN	NN	_	7	compound	_	_
7	content	content	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	expressed	express	VBN	VBN	_	4	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	fmol/mg	fmol/mg	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cytosolic	cytosolic	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	14	14	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	4	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	active	active	JJ	JJ	_	23	amod	_	_
23	SLE	sle	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	0.9356	0.9356	CD	CD	_	23	appos	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	0.31	0.31	CD	CD	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	was	be	VBD	VBD	_	31	cop	_	_
30	significantly	significantly	RB	RB	_	31	advmod	_	_
31	higher	higher	JJR	JJR	_	0	root	_	_
32	than	than	IN	IN	_	33	case	_	_
33	that	that	DT	DT	_	31	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	13	13	CD	CD	_	36	nummod	_	_
36	patients	patient	NNS	NNS	_	33	nmod	_	_
37	with	with	IN	IN	_	39	case	_	_
38	inactive	inactive	JJ	JJ	_	39	amod	_	_
39	SLE	sle	NN	NN	_	36	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	0.2979	0.2979	CD	CD	_	39	dep	_	_
42	+/-	+/-	CC	CC	_	41	cc	_	_
43	0.23	0.23	CD	CD	_	41	conj	_	_
44	,	,	,	,	_	41	punct	_	_
45	P	p	NN	NN	_	41	appos	_	_
46	less	less	JJR	JJR	_	45	amod	_	_
47	than	than	IN	IN	_	48	case	_	_
48	0.001	0.001	CD	CD	_	46	nmod	_	_
49	)	)	-RRB-	-RRB-	_	41	punct	_	_
50	and	and	CC	CC	_	36	cc	_	_
51	in	in	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	controls	control	NNS	NNS	_	36	conj	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	0.6204	0.6204	CD	CD	_	53	dep	_	_
56	+/-	+/-	CC	CC	_	55	cc	_	_
57	0.52	0.52	CD	CD	_	55	conj	_	_
58	,	,	,	,	_	55	punct	_	_
59	P	p	NN	NN	_	55	appos	_	_
60	less	less	JJR	JJR	_	59	amod	_	_
61	than	than	IN	IN	_	62	case	_	_
62	0.001	0.001	CD	CD	_	60	nmod	_	_
63	)	)	-RRB-	-RRB-	_	55	punct	_	_
64	.	.	.	.	_	31	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	normal	normal	JJ	JJ	_	4	amod	_	_
3	upper	upper	JJ	JJ	_	2	dep	_	_
4	limit	limit	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	ER	er	NN	NN	_	7	compound	_	_
7	content	content	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	expressed	express	VBN	VBN	_	4	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	fmol/micrograms	fmol/micrograms	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	DNA	dna	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	0.136	0.136	CD	CD	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	elevated	elevated	JJ	JJ	_	3	amod	_	_
3	rate	rate	NN	NN	_	19	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	ER	er	NN	NN	_	6	compound	_	_
6	content	content	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	14	14	CD	CD	_	12	nummod	_	_
11	active	active	JJ	JJ	_	12	amod	_	_
12	SLE	sle	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	92.9	92.9	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	was	be	VBD	VBD	_	19	cop	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	higher	higher	JJR	JJR	_	0	root	_	_
20	than	than	IN	IN	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	quieiescent	quieiescent	JJ	JJ	_	24	amod	_	_
24	patients	patient	NNS	NNS	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	23.1	23.1	CD	CD	_	27	nummod	_	_
27	%	%	NN	NN	_	24	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	P	p	NN	NN	_	27	appos	_	_
30	less	less	JJR	JJR	_	29	amod	_	_
31	than	than	IN	IN	_	32	case	_	_
32	0.001	0.001	CD	CD	_	30	nmod	_	_
33	)	)	-RRB-	-RRB-	_	27	punct	_	_
34	and	and	CC	CC	_	24	cc	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	controls	control	NNS	NNS	_	24	conj	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	10	10	CD	CD	_	40	nummod	_	_
40	%	%	NN	NN	_	37	dep	_	_
41	,	,	,	,	_	40	punct	_	_
42	P	p	NN	NN	_	40	appos	_	_
43	less	less	JJR	JJR	_	42	amod	_	_
44	than	than	IN	IN	_	45	case	_	_
45	0.001	0.001	CD	CD	_	43	nmod	_	_
46	)	)	-RRB-	-RRB-	_	40	punct	_	_
47	.	.	.	.	_	19	punct	_	_

1	Moreover	moreover	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	elevated	elevated	JJ	JJ	_	5	amod	_	_
5	level	level	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	ER	er	NN	NN	_	8	compound	_	_
8	content	content	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	related	related	JJ	JJ	_	10	xcomp	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	positive	positive	JJ	JJ	_	18	amod	_	_
17	antidsDNA	antidsdna	JJ	JJ	_	18	amod	_	_
18	antibody	antibody	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	hypocomplementemia	hypocomplementemia	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	murine	murine	JJ	JJ	_	4	amod	_	_
4	TCF-1	tcf-1	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	10	det	_	_
7	T	t	NN	NN	_	8	nmod:npmod	_	_
8	cell-specific	cell-specific	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	4	appos	_	_
11	interacting	interact	VBG	VBG	_	10	acl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	motifs	motif	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	CD3-epsilon	cd3-epsilon	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	T	t	NN	NN	_	23	compound	_	_
20	cell	cell	NN	NN	_	23	compound	_	_
21	receptor	receptor	NN	NN	_	23	compound	_	_
22	alpha	alpha	NN	NN	_	23	compound	_	_
23	enhancers	enhancer	NNS	NNS	_	17	conj	_	_
24	.	.	.	.	_	1	punct	_	_

1	CD3-epsilon	cd3-epsilon	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	confined	confine	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lineage	lineage	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cloned	clone	VBN	VBN	_	4	conj	_	_
7	a	a	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	4	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	TCF-1	tcf-1	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	binds	bind	VBZ	VBZ	_	10	acl:relcl	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	element	element	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	T	t	NN	NN	_	23	nmod:npmod	_	_
23	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	24	amod	_	_
24	enhancer	enhancer	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	CD3-epsilon	cd3-epsilon	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	panel	panel	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	TCF-1	tcf-1	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	12	nsubj	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	restricted	restricted	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	lineage	lineage	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	nsubj	_	_
2	belonged	belong	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	genes	gene	NNS	NNS	_	6	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	contain	contain	VBP	VBP	_	8	acl:relcl	_	_
11	the	the	DT	DT	_	20	det	_	_
12	so-called	so-called	JJ	JJ	_	20	amod	_	_
13	high	high	JJ	JJ	_	20	amod	_	_
14	mobility	mobility	NN	NN	_	20	compound	_	_
15	group	group	NN	NN	_	20	compound	_	_
16	1	1	CD	CD	_	20	nummod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	HMG	hmg	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	box	box	NN	NN	_	10	dobj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cloning	cloning	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	murine	murine	JJ	JJ	_	8	amod	_	_
8	TCF-1	tcf-1	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	splice	splice	NN	NN	_	3	compound	_	_
3	alternatives	alternative	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	that	that	WDT	WDT	_	10	nsubjpass	_	_
7	were	be	VBD	VBD	_	10	auxpass	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	observed	observe	VBN	VBN	_	5	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	TCF-1	tcf-1	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Murine	murine	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	human	human	JJ	JJ	_	1	conj	_	_
4	TCF-1	tcf-1	NN	NN	_	5	nsubj	_	_
5	displayed	display	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	12	det	_	_
7	95.5	95.5	CD	CD	_	8	compound	_	_
8	%	%	NN	NN	_	12	nummod	_	_
9	overall	overall	JJ	JJ	_	12	amod	_	_
10	amino	amino	NN	NN	_	12	compound	_	_
11	acid	acid	NN	NN	_	12	compound	_	_
12	homology	homology	NN	NN	_	5	dobj	_	_
13	.	.	.	.	_	5	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	5	amod	_	_
2	murine	murine	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	human	human	JJ	JJ	_	2	conj	_	_
5	TCF-1	tcf-1	NN	NN	_	6	nsubj	_	_
6	recognized	recognize	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	same	same	JJ	JJ	_	10	amod	_	_
9	sequence	sequence	NN	NN	_	10	compound	_	_
10	motif	motif	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD3-epsilon	cd3-epsilon	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	6	nmod	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	judged	judge	VBN	VBN	_	6	advcl	_	_
17	by	by	IN	IN	_	23	case	_	_
18	gel	gel	NN	NN	_	19	compound	_	_
19	retardation	retardation	NN	NN	_	23	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	methylation	methylation	NN	NN	_	22	compound	_	_
22	interference	interference	NN	NN	_	19	conj	_	_
23	assays	assay	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	With	with	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	murine	murine	JJ	JJ	_	5	amod	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	11	nmod	_	_
6	several	several	JJ	JJ	_	7	amod	_	_
7	aspects	aspect	NNS	NNS	_	11	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TCF-1	tcf-1	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	First	first	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	deletion	deletion	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	a	a	DT	DT	_	8	det	_	_
8	region	region	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	TCF-1	tcf-1	NN	NN	_	8	nmod	_	_
11	containing	contain	VBG	VBG	_	8	acl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HMG	hmg	NN	NN	_	14	compound	_	_
14	box	box	NN	NN	_	11	dobj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	sufficient	sufficient	JJ	JJ	_	5	ccomp	_	_
17	for	for	IN	IN	_	19	case	_	_
18	sequence-specific	sequence-specific	JJ	JJ	_	19	amod	_	_
19	binding	binding	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Second	second	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	by	by	IN	IN	_	7	case	_	_
4	high	high	JJ	JJ	_	7	amod	_	_
5	stringency	stringency	NN	NN	_	7	compound	_	_
6	Northern	northern	NN	NN	_	7	compound	_	_
7	blotting	blotting	NN	NN	_	16	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	situ	situ	FW	FW	_	9	dep	_	_
11	hybridization	hybridization	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	16	punct	_	_
13	TCF-1	tcf-1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	shown	show	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	confined	confine	VBN	VBN	_	16	xcomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	thymus	thymus	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	to	to	TO	TO	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	areas	area	NNS	NNS	_	22	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	spleen	spleen	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	Third	third	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	TCF-1	tcf-1	NN	NN	_	4	nsubj	_	_
4	bound	bind	VBD	VBD	_	0	root	_	_
5	specifically	specifically	RB	RB	_	4	advmod	_	_
6	to	to	TO	TO	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	functional	functional	JJ	JJ	_	11	amod	_	_
9	T	t	NN	NN	_	10	nmod:npmod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	11	amod	_	_
11	element	element	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	21	case	_	_
13	the	the	DT	DT	_	21	det	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TCR-alpha	tcr-alpha	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	enhancer	enhancer	NN	NN	_	11	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	T	t	NN	NN	_	3	nmod:npmod	_	_
3	lineage-specific	lineage-specific	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	17	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	affinity	affinity	NN	NN	_	4	conj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	motifs	motif	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	TCR-alpha	tcr-alpha	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	CD3-epsilon	cd3-epsilon	NN	NN	_	13	conj	_	_
16	enhancers	enhancer	NNS	NNS	_	10	nmod	_	_
17	imply	imply	VBP	VBP	_	0	root	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	TCF-1	tcf-1	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	establishment	establishment	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	mature	mature	JJ	JJ	_	31	amod	_	_
29	T	t	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	phenotype	phenotype	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	17	punct	_	_

1	HIV	hiv	NN	NN	_	3	compound	_	_
2	enhancer	enhancer	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	0	root	_	_
4	perpetuated	perpetuate	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	4	nmod	_	_
9	on	on	IN	IN	_	10	case	_	_
10	infection	infection	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	-LSB-	-lsb-	-LRB-	-LRB-	_	14	punct	_	_
14	see	see	VB	VB	_	3	dep	_	_
15	comments	comment	NNS	NNS	_	14	dobj	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	14	punct	_	_

1	Permissiveness	permissiveness	NN	NN	_	11	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	replication	replication	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HIV	hiv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	differs	differ	VBZ	VBZ	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	macrophages	macrophage	NNS	NNS	_	14	conj	_	_
17	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	poorly	poorly	RB	RB	_	9	advmod	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Cloned	clone	VBN	VBN	_	5	amod	_	_
2	,	,	,	,	_	1	punct	_	_
3	normal	normal	JJ	JJ	_	1	dep	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	little	little	JJ	JJ	_	14	amod	_	_
9	,	,	,	,	_	11	punct	_	_
10	if	if	IN	IN	_	11	mark	_	_
11	any	any	DT	DT	_	14	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	basal	basal	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	6	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HIV	hiv	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	low	low	JJ	JJ	_	22	amod	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	14	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	a	a	DT	DT	_	30	det	_	_
28	potent	potent	JJ	JJ	_	30	amod	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	activator	activator	NN	NN	_	25	appos	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	HIV	hiv	NN	NN	_	34	compound	_	_
34	enhancer	enhancer	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	fixed	fixed	JJ	JJ	_	6	amod	_	_
5	tissue	tissue	NN	NN	_	6	compound	_	_
6	macrophages	macrophage	NNS	NNS	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	0	root	_	_
8	detectable	detectable	JJ	JJ	_	10	amod	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	indicating	indicate	VBG	VBG	_	7	advcl	_	_
13	permanent	permanent	JJ	JJ	_	15	amod	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	explanation	explanation	NN	NN	_	17	nsubj	_	_
3	for	for	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	perpetuation	perpetuation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
11	could	could	MD	MD	_	17	aux	_	_
12	be	be	VB	VB	_	17	cop	_	_
13	sustained	sustained	JJ	JJ	_	17	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	U937	u937	NN	NN	_	7	compound	_	_
5	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	18	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	fully	fully	RB	RB	_	12	advmod	_	_
12	permissive	permissive	JJ	JJ	_	7	acl:relcl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	known	know	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	express	express	VB	VB	_	18	xcomp	_	_
21	only	only	RB	RB	_	22	advmod	_	_
22	low	low	JJ	JJ	_	23	amod	_	_
23	levels	level	NNS	NNS	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	chronic	chronic	JJ	JJ	_	7	amod	_	_
6	HIV	hiv	VBP	VBP	_	7	dep	_	_
7	infection	infection	NN	NN	_	8	nsubj	_	_
8	results	result	VBZ	VBZ	_	2	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	11	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	antigenic	antigenic	JJ	JJ	_	18	amod	_	_
18	properties	property	NNS	NNS	_	15	nmod	_	_
19	indistinguishable	indistinguishable	JJ	JJ	_	18	amod	_	_
20	from	from	IN	IN	_	21	case	_	_
21	those	those	DT	DT	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	11	cc	_	_
26	permanently	permanently	RB	RB	_	27	advmod	_	_
27	increased	increase	VBN	VBN	_	30	amod	_	_
28	HIV	hiv	NN	NN	_	30	compound	_	_
29	enhancer	enhancer	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	11	conj	_	_
31	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenomenon	phenomenon	NN	NN	_	13	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	independent	independent	JJ	JJ	_	2	acl:relcl	_	_
7	of	of	IN	IN	_	10	case	_	_
8	tumour	tumour	NN	NN	_	10	compound	_	_
9	necrosis	necrosis	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	HIV	hiv	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	is	be	VBZ	VBZ	_	21	cop	_	_
20	thus	thus	RB	RB	_	21	advmod	_	_
21	likely	likely	JJ	JJ	_	13	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	explain	explain	VB	VB	_	21	xcomp	_	_
24	at	at	IN	IN	_	27	advmod	_	_
25	least	least	JJS	JJS	_	24	mwe	_	_
26	in	in	IN	IN	_	27	case	_	_
27	part	part	NN	NN	_	23	nmod	_	_
28	the	the	DT	DT	_	29	det	_	_
29	perpetuation	perpetuation	NN	NN	_	23	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	HIV	hiv	NN	NN	_	32	compound	_	_
32	infection	infection	NN	NN	_	29	nmod	_	_
33	in	in	IN	IN	_	34	case	_	_
34	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
5	virus	virus	NN	NN	_	7	compound	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	antigen	antigen	NN	NN	_	1	nmod	_	_
8	2	2	CD	CD	_	7	nummod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	viral	viral	JJ	JJ	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	1	nmod	_	_
12	switching	switch	VBG	VBG	_	11	amod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	initial	initial	JJ	JJ	_	15	amod	_	_
15	stages	stage	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	infection	infection	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	During	during	IN	IN	_	8	case	_	_
2	latent	latent	JJ	JJ	_	8	amod	_	_
3	Epstein-Barr	epstein-barr	JJ	JJ	_	4	amod	_	_
4	virus	virus	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EBV	ebv	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	infection	infection	NN	NN	_	22	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	22	punct	_	_
14	six	six	CD	CD	_	17	nummod	_	_
15	viral	viral	JJ	JJ	_	17	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	antigen	antigen	NN	NN	_	22	nsubjpass	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	EBNAs	ebna	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	0	root	_	_
23	from	from	IN	IN	_	26	case	_	_
24	long	long	JJ	JJ	_	26	amod	_	_
25	primary	primary	JJ	JJ	_	26	amod	_	_
26	transcripts	transcript	NNS	NNS	_	22	nmod	_	_
27	by	by	IN	IN	_	31	case	_	_
28	means	means	NNS	NNS	_	31	dep	_	_
29	of	of	IN	IN	_	31	case	_	_
30	alternative	alternative	JJ	JJ	_	31	amod	_	_
31	splicing	splicing	NN	NN	_	22	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	alternative	alternative	JJ	JJ	_	35	amod	_	_
34	polyadenylylation	polyadenylylation	NN	NN	_	35	compound	_	_
35	sites	site	NNS	NNS	_	31	conj	_	_
36	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	transcripts	transcript	NNS	NNS	_	3	nsubj	_	_
3	initiate	initiate	VBP	VBP	_	0	root	_	_
4	from	from	IN	IN	_	5	case	_	_
5	one	one	CD	CD	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	promoters	promoter	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	Cp	cp	NN	NN	_	8	appos	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	Wp	wp	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	function	function	VBP	VBP	_	8	acl:relcl	_	_
16	in	in	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	mutually	mutually	RB	RB	_	19	advmod	_	_
19	exclusive	exclusive	JJ	JJ	_	20	amod	_	_
20	fashion	fashion	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Wp	wp	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	exclusively	exclusively	RB	RB	_	4	advmod	_	_
4	utilized	utilize	VBN	VBN	_	0	root	_	_
5	during	during	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	initial	initial	JJ	JJ	_	8	amod	_	_
8	stages	stage	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	infection	infection	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	primary	primary	JJ	JJ	_	14	amod	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	followed	follow	VBN	VBN	_	4	dep	_	_
17	by	by	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	switch	switch	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	Cp	cp	NN	NN	_	22	compound	_	_
22	usage	usage	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	extended	extend	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	show	show	VB	VB	_	5	xcomp	_	_
8	that	that	IN	IN	_	22	mark	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	i	i	LS	LS	_	22	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	a	a	DT	DT	_	15	det	_	_
13	mutant	mutant	JJ	JJ	_	15	amod	_	_
14	EBV	ebv	NN	NN	_	15	compound	_	_
15	strain	strain	NN	NN	_	22	nsubj	_	_
16	lacking	lack	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	gene	gene	NN	NN	_	16	dobj	_	_
19	encoding	encode	VBG	VBG	_	18	acl	_	_
20	EBNA	ebna	NN	NN	_	19	dobj	_	_
21	2	2	CD	CD	_	20	nummod	_	_
22	fails	fail	VBZ	VBZ	_	7	ccomp	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	switch	switch	VB	VB	_	22	xcomp	_	_
25	from	from	IN	IN	_	26	case	_	_
26	Wp	wp	NN	NN	_	29	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	Cp	cp	NN	NN	_	29	nmod	_	_
29	usage	usage	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	primary	primary	JJ	JJ	_	33	amod	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
34	,	,	,	,	_	24	punct	_	_
35	although	although	IN	IN	_	38	mark	_	_
36	the	the	DT	DT	_	37	det	_	_
37	virus	virus	NN	NN	_	38	nsubj	_	_
38	contains	contain	VBZ	VBZ	_	24	advcl	_	_
39	a	a	DT	DT	_	41	det	_	_
40	functional	functional	JJ	JJ	_	41	amod	_	_
41	Cp	cp	NN	NN	_	38	dobj	_	_
42	;	;	:	:	_	22	punct	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	ii	ii	LS	LS	_	58	dep	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	a	a	DT	DT	_	47	det	_	_
47	region	region	NN	NN	_	58	nsubj	_	_
48	from	from	IN	IN	_	51	advmod	_	_
49	-429	-429	CD	CD	_	51	compound	_	_
50	to	to	TO	TO	_	51	dep	_	_
51	-245	-245	CD	CD	_	53	nummod	_	_
52	base	base	NN	NN	_	53	compound	_	_
53	pairs	pair	NNS	NNS	_	47	dep	_	_
54	upstream	upstream	JJ	JJ	_	47	amod	_	_
55	of	of	IN	IN	_	56	case	_	_
56	Cp	cp	NN	NN	_	54	nmod	_	_
57	is	be	VBZ	VBZ	_	58	cop	_	_
58	essential	essential	JJ	JJ	_	22	conj	_	_
59	for	for	IN	IN	_	61	case	_	_
60	Cp	cp	NN	NN	_	61	compound	_	_
61	activity	activity	NN	NN	_	58	nmod	_	_
62	in	in	IN	IN	_	64	case	_	_
63	B	b	NN	NN	_	64	compound	_	_
64	lymphocytes	lymphocyte	NNS	NNS	_	61	nmod	_	_
65	,	,	,	,	_	58	punct	_	_
66	but	but	CC	CC	_	58	cc	_	_
67	only	only	RB	RB	_	70	advmod	_	_
68	in	in	IN	IN	_	70	case	_	_
69	the	the	DT	DT	_	70	det	_	_
70	context	context	NN	NN	_	58	conj	_	_
71	of	of	IN	IN	_	75	case	_	_
72	upstream	upstream	JJ	JJ	_	75	amod	_	_
73	and	and	CC	CC	_	72	cc	_	_
74	downstream	downstream	JJ	JJ	_	72	conj	_	_
75	sequences	sequence	NNS	NNS	_	70	nmod	_	_
76	;	;	:	:	_	22	punct	_	_
77	(	(	-LRB-	-LRB-	_	78	punct	_	_
78	iii	iii	LS	LS	_	82	dep	_	_
79	)	)	-RRB-	-RRB-	_	78	punct	_	_
80	this	this	DT	DT	_	81	det	_	_
81	region	region	NN	NN	_	82	nsubj	_	_
82	contains	contain	VBZ	VBZ	_	22	conj	_	_
83	an	a	DT	DT	_	86	det	_	_
84	EBNA	ebna	NN	NN	_	86	compound	_	_
85	2-dependent	2-dependent	JJ	JJ	_	86	amod	_	_
86	enhancer	enhancer	NN	NN	_	82	dobj	_	_
87	;	;	:	:	_	22	punct	_	_
88	and	and	CC	CC	_	22	cc	_	_
89	(	(	-LRB-	-LRB-	_	90	punct	_	_
90	iv	iv	LS	LS	_	103	dep	_	_
91	)	)	-RRB-	-RRB-	_	90	punct	_	_
92	DNase	dnase	NN	NN	_	94	compound	_	_
93	I	i	CD	CD	_	94	nummod	_	_
94	protection	protection	NN	NN	_	103	nsubj	_	_
95	employing	employ	VBG	VBG	_	94	acl	_	_
96	nuclear	nuclear	JJ	JJ	_	97	amod	_	_
97	extracts	extract	NNS	NNS	_	95	dobj	_	_
98	from	from	IN	IN	_	102	case	_	_
99	B	b	NN	NN	_	102	compound	_	_
100	and	and	CC	CC	_	99	cc	_	_
101	T	t	NN	NN	_	99	conj	_	_
102	lymphocytes	lymphocyte	NNS	NNS	_	97	nmod	_	_
103	revealed	reveal	VBD	VBD	_	22	conj	_	_
104	a	a	DT	DT	_	106	det	_	_
105	B-cell-specific	b-cell-specific	JJ	JJ	_	106	amod	_	_
106	footprint	footprint	NN	NN	_	103	dobj	_	_
107	in	in	IN	IN	_	109	case	_	_
108	the	the	DT	DT	_	109	det	_	_
109	region	region	NN	NN	_	106	nmod	_	_
110	of	of	IN	IN	_	114	case	_	_
111	the	the	DT	DT	_	114	det	_	_
112	EBNA	ebna	NN	NN	_	113	nmod:npmod	_	_
113	2-dependent	2-dependent	JJ	JJ	_	114	amod	_	_
114	enhancer	enhancer	NN	NN	_	109	nmod	_	_
115	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	viral	viral	JJ	JJ	_	9	amod	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	switching	switching	NN	NN	_	5	nmod	_	_
10	during	during	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	initial	initial	JJ	JJ	_	13	amod	_	_
13	stages	stage	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	infection	infection	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	20	nmod	_	_
18	Wp	wp	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	20	nsubj	_	_
20	leads	lead	VBZ	VBZ	_	13	dep	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	EBNA	ebna	NN	NN	_	23	nmod	_	_
26	2	2	CD	CD	_	25	nummod	_	_
27	,	,	,	,	_	20	punct	_	_
28	followed	follow	VBN	VBN	_	20	dep	_	_
29	by	by	IN	IN	_	30	case	_	_
30	activation	activation	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	Cp	cp	NN	NN	_	30	nmod	_	_
33	through	through	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	EBNA	ebna	NN	NN	_	36	nmod:npmod	_	_
36	2-dependent	2-dependent	JJ	JJ	_	37	amod	_	_
37	enhancer	enhancer	NN	NN	_	30	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	corticosteroid-resistant	corticosteroid-resistant	JJ	JJ	_	11	amod	_	_
10	bronchial	bronchial	JJ	JJ	_	11	amod	_	_
11	asthma	asthma	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	corticosteroid	corticosteroid	NN	NN	_	5	compound	_	_
5	resistance	resistance	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	bronchial	bronchial	JJ	JJ	_	8	amod	_	_
8	asthma	asthma	NN	NN	_	2	nmod	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	studied	study	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	determining	determine	VBG	VBG	_	11	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	rank	rank	NN	NN	_	16	compound	_	_
16	order	order	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	potency	potency	NN	NN	_	16	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	different	different	JJ	JJ	_	21	amod	_	_
21	corticosteroids	corticosteroid	NNS	NNS	_	16	nmod	_	_
22	in	in	IN	IN	_	23	mark	_	_
23	inhibiting	inhibit	VBG	VBG	_	16	acl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	generation	generation	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	3	3	CD	CD	_	29	compound	_	_
29	kD	kd	NN	NN	_	30	amod	_	_
30	molecule	molecule	NN	NN	_	25	nmod	_	_
31	from	from	IN	IN	_	34	case	_	_
32	peripheral	peripheral	JJ	JJ	_	34	amod	_	_
33	blood	blood	NN	NN	_	34	compound	_	_
34	monocytes	monocyte	NNS	NNS	_	25	nmod	_	_
35	isolated	isolate	VBN	VBN	_	34	acl	_	_
36	from	from	IN	IN	_	47	case	_	_
37	corticosteroid-sensitive	corticosteroid-sensitive	JJ	JJ	_	47	amod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	CS	cs	JJ	JJ	_	37	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	corticosteroid-resistant	corticosteroid-resistant	JJ	JJ	_	37	conj	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	CR	cr	JJ	JJ	_	42	dep	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	asthmatic	asthmatic	JJ	JJ	_	47	amod	_	_
47	subjects	subject	NNS	NNS	_	35	nmod	_	_
48	,	,	,	,	_	23	punct	_	_
49	which	which	WDT	WDT	_	50	nsubj	_	_
50	augments	augment	VBZ	VBZ	_	23	ccomp	_	_
51	leukotriene	leukotriene	NN	NN	_	52	compound	_	_
52	B4	b4	NN	NN	_	56	compound	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	LTB4	ltb4	NN	NN	_	52	appos	_	_
55	)	)	-RRB-	-RRB-	_	54	punct	_	_
56	generation	generation	NN	NN	_	50	dobj	_	_
57	by	by	IN	IN	_	59	case	_	_
58	human	human	JJ	JJ	_	59	amod	_	_
59	neutrophils	neutrophil	NNS	NNS	_	56	nmod	_	_
60	(	(	-LRB-	-LRB-	_	61	punct	_	_
61	PMN	pmn	NN	NN	_	59	appos	_	_
62	)	)	-RRB-	-RRB-	_	61	punct	_	_
63	stimulated	stimulate	VBN	VBN	_	59	acl	_	_
64	by	by	IN	IN	_	66	case	_	_
65	calcium	calcium	NN	NN	_	66	compound	_	_
66	ionophore	ionophore	NN	NN	_	63	nmod	_	_
67	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	studies	study	NNS	NNS	_	13	nsubjpass	_	_
6	with	with	IN	IN	_	10	case	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	3H	3h	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	performed	perform	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	determine	determine	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	dissociation	dissociation	NN	NN	_	18	compound	_	_
18	constant	constant	NN	NN	_	15	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Kd	kd	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	numbers	number	NNS	NNS	_	18	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Ro	ro	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	these	these	DT	DT	_	34	det	_	_
33	two	two	CD	CD	_	34	nummod	_	_
34	groups	group	NNS	NNS	_	30	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	subjects	subject	NNS	NNS	_	34	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentration	concentration	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	corticosteroid	corticosteroid	NN	NN	_	2	nmod	_	_
5	producing	produce	VBG	VBG	_	4	acl	_	_
6	50	50	CD	CD	_	8	nummod	_	_
7	%	%	NN	NN	_	8	compound	_	_
8	inhibition	inhibition	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IC50	ic50	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	600	600	CD	CD	_	14	nummod	_	_
14	nM	nm	NN	NN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	70	70	CD	CD	_	17	nummod	_	_
17	nM	nm	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	0.5	0.5	CD	CD	_	21	nummod	_	_
21	nM	nm	NN	NN	_	14	conj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	hydrocortisone	hydrocortisone	NN	NN	_	14	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	methylprednisolone	methylprednisolone	NN	NN	_	14	conj	_	_
26	,	,	,	,	_	14	punct	_	_
27	and	and	CC	CC	_	14	cc	_	_
28	dexamethasone	dexamethasone	NN	NN	_	14	conj	_	_
29	,	,	,	,	_	14	punct	_	_
30	respectively	respectively	RB	RB	_	14	advmod	_	_
31	,	,	,	,	_	14	punct	_	_
32	in	in	IN	IN	_	33	case	_	_
33	monocytes	monocyte	NNS	NNS	_	14	conj	_	_
34	from	from	IN	IN	_	36	case	_	_
35	CS	cs	JJ	JJ	_	36	amod	_	_
36	individuals	individual	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	weak	weak	JJ	JJ	_	5	amod	_	_
5	inhibition	inhibition	NN	NN	_	2	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	generation	generation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	enhancing	enhancing	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	corticosteroids	corticosteroid	NNS	NNS	_	5	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	CR	cr	JJ	JJ	_	18	amod	_	_
18	asthmatic	asthmatic	JJ	JJ	_	19	amod	_	_
19	individuals	individual	NNS	NNS	_	2	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dexamethasone	dexamethasone	NN	NN	_	3	compound	_	_
3	Kd	kd	NN	NN	_	8	nsubj	_	_
4	was	be	VBD	VBD	_	8	cop	_	_
5	2.45	2.45	CD	CD	_	8	nummod	_	_
6	+/-	+/-	CC	CC	_	5	cc	_	_
7	0.58	0.58	CD	CD	_	5	conj	_	_
8	nM	nm	NN	NN	_	0	root	_	_
9	(	(	-LRB-	-LRB-	_	15	punct	_	_
10	mean	mean	NN	NN	_	15	dep	_	_
11	+/-	+/-	CC	CC	_	10	cc	_	_
12	SEM	sem	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	15	punct	_	_
14	n	n	NN	NN	_	15	nsubj	_	_
15	=	=	JJ	JJ	_	8	dep	_	_
16	6	6	CD	CD	_	15	dobj	_	_
17	)	)	-RRB-	-RRB-	_	15	punct	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CS	cs	JJ	JJ	_	21	compound	_	_
21	group	group	NN	NN	_	8	nmod	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	1.6	1.6	CD	CD	_	26	nummod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	0.35	0.35	CD	CD	_	23	conj	_	_
26	nM	nm	NN	NN	_	8	conj	_	_
27	(	(	-LRB-	-LRB-	_	33	punct	_	_
28	mean	mean	NN	NN	_	33	dep	_	_
29	+/-	+/-	CC	CC	_	28	cc	_	_
30	SEM	sem	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	33	punct	_	_
32	n	n	NN	NN	_	33	nsubj	_	_
33	=	=	JJ	JJ	_	26	dep	_	_
34	6	6	CD	CD	_	33	dobj	_	_
35	)	)	-RRB-	-RRB-	_	33	punct	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	CR	cr	JJ	JJ	_	39	compound	_	_
39	group	group	NN	NN	_	26	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	patients	patient	NNS	NNS	_	39	nmod	_	_
42	(	(	-LRB-	-LRB-	_	44	punct	_	_
43	p	p	NN	NN	_	44	nsubj	_	_
44	=	=	JJ	JJ	_	8	parataxis	_	_
45	0.14	0.14	CD	CD	_	44	dobj	_	_
46	)	)	-RRB-	-RRB-	_	44	punct	_	_
47	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	Ro	ro	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CS	cs	JJ	JJ	_	6	amod	_	_
6	group	group	NN	NN	_	12	nmod	_	_
7	was	be	VBD	VBD	_	12	cop	_	_
8	3,605	3,605	CD	CD	_	12	nummod	_	_
9	+/-	+/-	CC	CC	_	8	cc	_	_
10	984	984	CD	CD	_	8	conj	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	sites	site	NNS	NNS	_	0	root	_	_
13	per	per	IN	IN	_	14	case	_	_
14	nucleus	nucleus	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	mean	mean	NN	NN	_	21	dep	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	SEM	sem	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	21	punct	_	_
20	n	n	NN	NN	_	21	nsubj	_	_
21	=	=	JJ	JJ	_	12	parataxis	_	_
22	6	6	CD	CD	_	21	dobj	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	and	and	CC	CC	_	12	cc	_	_
25	4,757	4,757	CD	CD	_	29	nummod	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	692	692	CD	CD	_	25	conj	_	_
28	binding	bind	VBG	VBG	_	29	amod	_	_
29	sites	site	NNS	NNS	_	12	conj	_	_
30	per	per	IN	IN	_	31	case	_	_
31	nucleus	nucleus	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	38	punct	_	_
33	mean	mean	NN	NN	_	38	dep	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	SEM	sem	NN	NN	_	33	conj	_	_
36	,	,	,	,	_	38	punct	_	_
37	n	n	NN	NN	_	38	nsubj	_	_
38	=	=	JJ	JJ	_	29	parataxis	_	_
39	6	6	CD	CD	_	38	dobj	_	_
40	)	)	-RRB-	-RRB-	_	38	punct	_	_
41	in	in	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	CR	cr	JJ	JJ	_	44	amod	_	_
44	group	group	NN	NN	_	29	nmod	_	_
45	(	(	-LRB-	-LRB-	_	47	punct	_	_
46	p	p	NN	NN	_	47	nsubj	_	_
47	=	=	JJ	JJ	_	12	parataxis	_	_
48	0.23	0.23	CD	CD	_	47	dobj	_	_
49	)	)	-RRB-	-RRB-	_	47	punct	_	_
50	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	corticosteroid	corticosteroid	NN	NN	_	6	compound	_	_
6	resistance	resistance	NN	NN	_	13	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	bronchial	bronchial	JJ	JJ	_	9	amod	_	_
9	asthma	asthma	NN	NN	_	6	nmod	_	_
10	can	can	MD	MD	_	13	aux	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	explained	explain	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	abnormalities	abnormality	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	corticosteroid	corticosteroid	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	characteristics	characteristic	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Tissue-specific	tissue-specific	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	platelet	platelet	NN	NN	_	7	compound	_	_
6	GPIIb	gpiib	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	One	one	CD	CD	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	major	major	JJ	JJ	_	5	amod	_	_
5	objectives	objective	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	study	study	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	thrombogenesis	thrombogenesis	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	determine	determine	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanisms	mechanism	NNS	NNS	_	13	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	22	nmod	_	_
18	a	a	DT	DT	_	20	det	_	_
19	hematopoietic	hematopoietic	JJ	JJ	_	20	amod	_	_
20	progenitor	progenitor	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	activated	activate	VBN	VBN	_	15	acl:relcl	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	committed	commit	VBN	VBN	_	22	conj	_	_
25	to	to	TO	TO	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	megakaryocytic	megakaryocytic	JJ	JJ	_	28	amod	_	_
28	lineage	lineage	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	development	development	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	primary	primary	JJ	JJ	_	5	amod	_	_
5	cultures	culture	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	megakaryocytes	megakaryocyte	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	cloning	cloning	NN	NN	_	2	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	genes	gene	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	specific	specific	JJ	JJ	_	14	acl:relcl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	lineage	lineage	NN	NN	_	17	nmod	_	_
21	offer	offer	VBP	VBP	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	possibility	possibility	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	mark	_	_
25	getting	get	VBG	VBG	_	23	acl	_	_
26	some	some	DT	DT	_	27	det	_	_
27	insights	insight	NNS	NNS	_	25	dobj	_	_
28	into	into	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	genetic	genetic	JJ	JJ	_	31	amod	_	_
31	mechanisms	mechanism	NNS	NNS	_	27	nmod	_	_
32	that	that	WDT	WDT	_	33	nsubj	_	_
33	control	control	VBP	VBP	_	31	acl:relcl	_	_
34	megakaryocytopoiesis	megakaryocytopoiesis	NNS	NNS	_	33	dobj	_	_
35	.	.	.	.	_	21	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	gene	gene	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interest	interest	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	12	cop	_	_
6	the	the	DT	DT	_	12	det	_	_
7	glycoprotein	glycoprotein	NN	NN	_	8	compound	_	_
8	IIb	iib	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	GPIIb	gpiib	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	gene	gene	NN	NN	_	0	root	_	_
13	;	;	:	:	_	12	punct	_	_
14	GPIIb	gpiib	NN	NN	_	26	nsubjpass	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	alpha	alpha	NN	NN	_	18	compound	_	_
18	subunit	subunit	NN	NN	_	14	appos	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	platelet	platelet	NN	NN	_	23	compound	_	_
22	cytoadhesin	cytoadhesin	NN	NN	_	23	compound	_	_
23	GPIIb-IIIa	gpiib-iiia	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	produced	produce	VBN	VBN	_	12	parataxis	_	_
27	in	in	IN	IN	_	28	case	_	_
28	megakaryocytes	megakaryocyte	NNS	NNS	_	26	nmod	_	_
29	at	at	IN	IN	_	32	case	_	_
30	an	a	DT	DT	_	32	det	_	_
31	early	early	JJ	JJ	_	32	amod	_	_
32	stage	stage	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	differentiation	differentiation	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	26	punct	_	_
37	whereas	whereas	IN	IN	_	26	dep	_	_
38	the	the	DT	DT	_	40	det	_	_
39	other	other	JJ	JJ	_	40	amod	_	_
40	subunit	subunit	NN	NN	_	48	nsubjpass	_	_
41	of	of	IN	IN	_	43	case	_	_
42	this	this	DT	DT	_	43	det	_	_
43	complex	complex	NN	NN	_	40	nmod	_	_
44	,	,	,	,	_	40	punct	_	_
45	GPIIIa	gpiiia	NN	NN	_	40	appos	_	_
46	,	,	,	,	_	40	punct	_	_
47	is	be	VBZ	VBZ	_	48	auxpass	_	_
48	expressed	express	VBN	VBN	_	26	parataxis	_	_
49	in	in	IN	IN	_	51	case	_	_
50	other	other	JJ	JJ	_	51	amod	_	_
51	cells	cell	NNS	NNS	_	48	nmod	_	_
52	.	.	.	.	_	26	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	reasons	reason	NNS	NNS	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	5'-flanking	5'-flanking	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	GPIIb	gpiib	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	used	use	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	identify	identify	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regions	region	NNS	NNS	_	15	dobj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	interact	interact	VBP	VBP	_	17	acl:relcl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	fragment	fragment	NN	NN	_	9	nsubj	_	_
3	extending	extend	VBG	VBG	_	2	acl	_	_
4	from	from	IN	IN	_	5	case	_	_
5	-643	-643	CD	CD	_	3	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	+33	+33	CD	CD	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	capable	capable	JJ	JJ	_	0	root	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	controlling	control	VBG	VBG	_	9	advcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CAT	cat	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	transfection	transfection	NN	NN	_	21	compound	_	_
21	experiments	experiment	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	several	several	JJ	JJ	_	9	amod	_	_
9	sequences	sequence	NNS	NNS	_	7	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	implicated	implicate	VBN	VBN	_	9	acl:relcl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	interactions	interaction	NNS	NNS	_	12	nmod	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	shown	show	VBN	VBN	_	12	advcl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	DNAse	dnase	NN	NN	_	22	compound	_	_
21	I	i	NN	NN	_	22	compound	_	_
22	footprints	footprint	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	gel	gel	NN	NN	_	27	compound	_	_
25	mobility	mobility	NN	NN	_	27	compound	_	_
26	shift	shift	NN	NN	_	27	compound	_	_
27	assays	assay	NNS	NNS	_	22	conj	_	_
28	.	.	.	.	_	7	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	region	region	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	centered	center	VBN	VBN	_	2	amod	_	_
5	at	at	IN	IN	_	6	case	_	_
6	-54	-54	CD	CD	_	4	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor	factor	NN	NN	_	14	nmod:npmod	_	_
14	E1-binding	e1-binding	JJ	JJ	_	15	amod	_	_
15	site	site	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	a	a	DT	DT	_	19	det	_	_
19	region	region	NN	NN	_	24	nsubj	_	_
20	located	located	JJ	JJ	_	19	amod	_	_
21	at	at	IN	IN	_	22	case	_	_
22	position	position	NN	NN	_	20	nmod	_	_
23	-233	-233	CD	CD	_	22	nummod	_	_
24	contains	contain	VBZ	VBZ	_	9	conj	_	_
25	a	a	DT	DT	_	27	det	_	_
26	CCAAT	ccaat	NN	NN	_	27	compound	_	_
27	motif	motif	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	9	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	domains	domain	NNS	NNS	_	12	nsubj	_	_
3	centered	center	VBN	VBN	_	2	amod	_	_
4	at	at	IN	IN	_	5	case	_	_
5	positions	position	NNS	NNS	_	3	nmod	_	_
6	-345	-345	CD	CD	_	5	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	-540	-540	CD	CD	_	6	conj	_	_
9	,	,	,	,	_	3	punct	_	_
10	respectively	respectively	RB	RB	_	3	advmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	bind	bind	VBP	VBP	_	0	root	_	_
13	proteins	protein	NNS	NNS	_	12	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	present	present	JJ	JJ	_	13	acl:relcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	megakaryocytic	megakaryocytic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	nonrelated	nonrelated	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	conj	_	_
23	as	as	RB	RB	_	24	advmod	_	_
24	well	well	RB	RB	_	16	advcl	_	_
25	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	domains	domain	NNS	NNS	_	14	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	located	located	JJ	JJ	_	5	amod	_	_
8	at	at	IN	IN	_	9	case	_	_
9	positions	position	NNS	NNS	_	7	nmod	_	_
10	-460	-460	CD	CD	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	-510	-510	CD	CD	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	interact	interact	VBP	VBP	_	0	root	_	_
15	with	with	IN	IN	_	16	case	_	_
16	proteins	protein	NNS	NNS	_	14	nmod	_	_
17	that	that	WDT	WDT	_	20	nsubj	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	present	present	JJ	JJ	_	16	acl:relcl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	megakaryocytic	megakaryocytic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	deletion	deletion	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	region	region	NN	NN	_	4	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	these	these	DT	DT	_	11	det	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	domains	domain	NNS	NNS	_	8	dobj	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	significant	significant	JJ	JJ	_	16	amod	_	_
16	decrease	decrease	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	very	very	RB	RB	_	4	advmod	_	_
4	likely	likely	JJ	JJ	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	these	these	DT	DT	_	7	det	_	_
7	domains	domain	NNS	NNS	_	8	nsubj	_	_
8	bind	bind	VBP	VBP	_	4	ccomp	_	_
9	megakaryocyte-specific	megakaryocyte-specific	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	dobj	_	_
12	acting	act	VBG	VBG	_	11	acl	_	_
13	as	as	IN	IN	_	16	case	_	_
14	positive	positive	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Inhibition	inhibition	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	phosphatases	phosphatase	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	okadaic	okadaic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	1	nmod	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	AP1	ap1	NN	NN	_	8	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	phosphatases	phosphatase	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	treated	treat	VBN	VBN	_	2	parataxis	_	_
17	with	with	IN	IN	_	19	case	_	_
18	okadaic	okadaic	JJ	JJ	_	19	amod	_	_
19	acid	acid	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	an	a	DT	DT	_	22	det	_	_
22	inhibitor	inhibitor	NN	NN	_	19	appos	_	_
23	of	of	IN	IN	_	24	case	_	_
24	type	type	NN	NN	_	22	nmod	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	2A	2a	NN	NN	_	28	compound	_	_
28	phosphatases	phosphatase	NNS	NNS	_	24	conj	_	_
29	,	,	,	,	_	19	punct	_	_
30	and	and	CC	CC	_	16	cc	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	extracts	extract	NNS	NNS	_	34	nsubjpass	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	examined	examine	VBN	VBN	_	16	conj	_	_
35	for	for	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	presence	presence	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	AP1	ap1	NN	NN	_	37	nmod	_	_
40	as	as	IN	IN	_	42	case	_	_
41	a	a	DT	DT	_	42	det	_	_
42	measure	measure	NN	NN	_	34	nmod	_	_
43	of	of	IN	IN	_	47	case	_	_
44	early	early	JJ	JJ	_	47	amod	_	_
45	T	t	NN	NN	_	47	compound	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	activation	activation	NN	NN	_	42	nmod	_	_
48	.	.	.	.	_	2	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	9	mark	_	_
6	be	be	VB	VB	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	potent	potent	JJ	JJ	_	9	amod	_	_
9	inducer	inducer	NN	NN	_	4	xcomp	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AP1	ap1	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	phorbol	phorbol	NN	NN	_	5	compound	_	_
5	esters	ester	NNS	NNS	_	22	nmod	_	_
6	such	such	JJ	JJ	_	10	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	myristate	myristate	NN	NN	_	10	compound	_	_
10	acetate	acetate	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMA	pma	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	22	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	22	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	AP1	ap1	NN	NN	_	16	nmod	_	_
19	by	by	IN	IN	_	21	case	_	_
20	okadaic	okadaic	JJ	JJ	_	21	amod	_	_
21	acid	acid	NN	NN	_	16	nmod	_	_
22	occurs	occur	VBZ	VBZ	_	0	root	_	_
23	predominantly	predominantly	RB	RB	_	26	advmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	jun	jun	NN	NN	_	32	compound	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	fos	fos	NN	NN	_	29	conj	_	_
32	family	family	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	proto-oncogenes	proto-oncogene	NNS	NNS	_	32	nmod	_	_
35	.	.	.	.	_	22	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	while	while	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	addition	addition	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	phytohemagglutinin	phytohemagglutinin	NN	NN	_	5	nmod	_	_
8	further	further	RB	RB	_	9	advmod	_	_
9	enhanced	enhance	VBD	VBD	_	19	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	AP1	ap1	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	addition	addition	NN	NN	_	19	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	PMA	pma	NN	NN	_	16	nmod	_	_
19	inhibited	inhibit	VBD	VBD	_	0	root	_	_
20	it	it	PRP	PRP	_	19	dobj	_	_
21	.	.	.	.	_	19	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	3	amod	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	dramatically	dramatically	RB	RB	_	8	advmod	_	_
8	increase	increase	VB	VB	_	5	xcomp	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	transcripts	transcript	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	jun	jun	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	proto-oncogenes	proto-oncogene	NNS	NNS	_	14	nmod	_	_
17	including	include	VBG	VBG	_	18	case	_	_
18	c-jun	c-jun	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	junD	jund	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	junB	junb	NN	NN	_	18	conj	_	_
24	and	and	CC	CC	_	8	cc	_	_
25	to	to	TO	TO	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	lesser	lesser	JJR	JJR	_	28	amod	_	_
28	extent	extent	NN	NN	_	31	nmod	_	_
29	the	the	DT	DT	_	31	det	_	_
30	fos	fos	NN	NN	_	31	compound	_	_
31	family	family	NN	NN	_	8	conj	_	_
32	including	include	VBG	VBG	_	33	case	_	_
33	c-fos	c-fos	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	fra-1	fra-1	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	PMA	pma	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	inefficient	inefficient	JJ	JJ	_	9	amod	_	_
9	inducer	inducer	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	jun	jun	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	15	ccomp	_	_
2	to	to	TO	TO	_	4	case	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	effect	effect	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	AP1	ap1	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	okadaic	okadaic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	PMA	pma	NN	NN	_	15	nsubj	_	_
15	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	c-jun	c-jun	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	okadaic	okadaic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Transfection	transfection	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	c-jun	c-jun	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	1	nmod	_	_
6	confirmed	confirm	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	marked	marked	JJ	JJ	_	9	amod	_	_
9	difference	difference	NN	NN	_	6	dobj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	PMA	pma	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	okadaic	okadaic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	11	conj	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	inducing	induce	VBG	VBG	_	9	acl	_	_
17	c-jun	c-jun	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AP1	ap1	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	okadaic	okadaic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	2	nmod	_	_
8	suggests	suggest	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	22	mark	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	phosphatases	phosphatase	NNS	NNS	_	22	nsubjpass	_	_
12	1	1	CD	CD	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	2A	2a	NN	NN	_	12	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PP1	pp1	NN	NN	_	11	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	PP2A	pp2a	NN	NN	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	involved	involve	VBN	VBN	_	8	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	as	as	IN	IN	_	30	case	_	_
28	important	important	JJ	JJ	_	30	amod	_	_
29	negative	negative	JJ	JJ	_	30	amod	_	_
30	regulators	regulator	NNS	NNS	_	22	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	transcription	transcription	NN	NN	_	35	compound	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	AP1	ap1	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	8	punct	_	_

1	Demonstration	demonstration	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	estrogen	estrogen	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	progesterone	progesterone	NN	NN	_	3	conj	_	_
6	receptors	receptor	NNS	NNS	_	1	nmod	_	_
7	as	as	RB	RB	_	6	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	Ki-67	ki-67	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	p-145	p-145	NN	NN	_	10	conj	_	_
13	antigens	antigen	NNS	NNS	_	6	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	single	single	JJ	JJ	_	17	amod	_	_
16	tumor	tumor	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	from	from	IN	IN	_	22	case	_	_
19	blood	blood	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	pleural	pleural	JJ	JJ	_	19	conj	_	_
22	effusions	effusion	NNS	NNS	_	17	nmod	_	_
23	using	use	VBG	VBG	_	1	acl	_	_
24	a	a	DT	DT	_	26	det	_	_
25	slide	slide	NN	NN	_	26	compound	_	_
26	assay	assay	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	slide	slide	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	2	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	allows	allow	VBZ	VBZ	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	demonstration	demonstration	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	antigens	antigen	NNS	NNS	_	9	nmod	_	_
12	localized	localized	JJ	JJ	_	11	amod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	12	nmod	_	_
16	from	from	IN	IN	_	20	case	_	_
17	isolated	isolate	VBN	VBN	_	20	amod	_	_
18	white	white	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	as	as	RB	RB	_	20	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	from	from	IN	IN	_	27	case	_	_
25	single	single	JJ	JJ	_	27	amod	_	_
26	tumor	tumor	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	20	conj	_	_
28	derived	derive	VBN	VBN	_	27	acl	_	_
29	from	from	IN	IN	_	31	case	_	_
30	malignant	malignant	JJ	JJ	_	31	amod	_	_
31	effusions	effusion	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	antibodies	antibody	NNS	NNS	_	15	nmod	_	_
4	Ki-67	ki-67	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	anti-p-145	anti-p-145	NN	NN	_	4	conj	_	_
7	an	a	DT	DT	_	9	det	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	rate	rate	NN	NN	_	15	nsubj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	nucleolar	nucleolar	JJ	JJ	_	11	conj	_	_
14	staining	staining	NN	NN	_	9	nmod	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	from	from	IN	IN	_	21	case	_	_
19	highly	highly	RB	RB	_	20	advmod	_	_
20	malignant	malignant	JJ	JJ	_	21	amod	_	_
21	lymphomas	lymphoma	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	almost	almost	RB	RB	_	3	advmod	_	_
3	identical	identical	JJ	JJ	_	4	amod	_	_
4	reaction	reaction	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	obtained	obtain	VBN	VBN	_	0	root	_	_
7	when	when	WRB	WRB	_	14	advmod	_	_
8	tumor	tumor	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
10	from	from	IN	IN	_	12	case	_	_
11	malignant	malignant	JJ	JJ	_	12	amod	_	_
12	effusions	effusion	NNS	NNS	_	9	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	tested	test	VBN	VBN	_	6	advcl	_	_
15	.	.	.	.	_	6	punct	_	_

1	Cells	cell	NNS	NNS	_	16	nsubj	_	_
2	isolated	isolate	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	blood	blood	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	leukemic	leukemic	JJ	JJ	_	10	amod	_	_
10	spread	spread	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	lymphomas	lymphoma	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	low	low	JJ	JJ	_	15	amod	_	_
15	malignancy	malignancy	NN	NN	_	12	nmod	_	_
16	yielded	yield	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	weak	weak	JJ	JJ	_	19	amod	_	_
19	staining	staining	NN	NN	_	16	dobj	_	_
20	comparable	comparable	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	normal	normal	JJ	JJ	_	26	amod	_	_
25	mesothelial	mesothelial	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	from	from	IN	IN	_	30	case	_	_
28	non-tumorous	non-tumorous	JJ	JJ	_	30	amod	_	_
29	cavity	cavity	NN	NN	_	30	compound	_	_
30	fluids	fluid	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	detection	detection	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	estrogen	estrogen	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	progesterone	progesterone	NN	NN	_	4	conj	_	_
7	receptors	receptor	NNS	NNS	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	ER	er	NN	NN	_	7	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	PR	pr	NN	NN	_	9	conj	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	localized	localized	JJ	JJ	_	7	amod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	nucleus	nucleus	NN	NN	_	13	nmod	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	achieved	achieve	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	same	same	JJ	JJ	_	24	amod	_	_
24	assay	assay	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reaction	reaction	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	enhanced	enhance	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	incubation	incubation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	tumor	tumor	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	for	for	IN	IN	_	13	case	_	_
12	30	30	CD	CD	_	13	nummod	_	_
13	min	min	NN	NN	_	6	nmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	37	37	CD	CD	_	17	nummod	_	_
16	degrees	degree	NNS	NNS	_	17	compound	_	_
17	C	c	NN	NN	_	6	nmod	_	_
18	prior	prior	RB	RB	_	20	case	_	_
19	to	to	TO	TO	_	18	mwe	_	_
20	fixation	fixation	NN	NN	_	6	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Pleural	pleural	JJ	JJ	_	2	amod	_	_
2	effusions	effusion	NNS	NNS	_	10	nsubjpass	_	_
3	from	from	IN	IN	_	5	case	_	_
4	20	20	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	breast	breast	NN	NN	_	8	compound	_	_
8	cancer	cancer	NN	NN	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	tested	test	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	ER	er	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	positive	positive	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	13	13	CD	CD	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	PR	pr	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	positive	positive	JJ	JJ	_	3	conj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	12	12	CD	CD	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	20	20	CD	CD	_	15	nummod	_	_
15	samples	sample	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	5	5	CD	CD	_	3	nummod	_	_
3	cases	case	NNS	NNS	_	5	nmod	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	divergent	divergent	JJ	JJ	_	8	amod	_	_
8	reaction	reaction	NN	NN	_	5	nsubj	_	_
9	with	with	IN	IN	_	13	case	_	_
10	ER	er	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	PR	pr	NN	NN	_	10	conj	_	_
13	antibody	antibody	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	hormone	hormone	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	primary	primary	JJ	JJ	_	7	amod	_	_
7	tumor	tumor	NN	NN	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	known	know	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	15	15	CD	CD	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	ER	er	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	14	14	CD	CD	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PR	pr	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	patients	patient	NNS	NNS	_	11	dep	_	_
21	,	,	,	,	_	9	punct	_	_
22	respectively	respectively	RB	RB	_	9	advmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	each	each	DT	DT	_	3	det	_	_
3	cohort	cohort	NN	NN	_	5	nmod	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	one	one	CD	CD	_	8	nummod	_	_
8	case	case	NN	NN	_	5	nsubj	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	negative	negative	JJ	JJ	_	12	amod	_	_
12	reaction	reaction	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	primary	primary	JJ	JJ	_	16	amod	_	_
16	tumor	tumor	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	positive	positive	JJ	JJ	_	20	amod	_	_
20	reaction	reaction	NN	NN	_	12	conj	_	_
21	with	with	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	isolated	isolate	VBN	VBN	_	25	amod	_	_
24	tumor	tumor	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	from	from	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	pleural	pleural	JJ	JJ	_	29	amod	_	_
29	effusions	effusion	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	demonstration	demonstration	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	hormone	hormone	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	malignant	malignant	JJ	JJ	_	15	amod	_	_
15	effusions	effusion	NNS	NNS	_	12	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	possible	possible	JJ	JJ	_	3	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	there	there	EX	EX	_	21	expl	_	_
21	is	be	VBZ	VBZ	_	17	conj	_	_
22	a	a	DT	DT	_	23	det	_	_
23	correlation	correlation	NN	NN	_	21	nsubj	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	status	status	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	primary	primary	JJ	JJ	_	30	amod	_	_
30	site	site	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	cancer	cancer	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Transforming	transform	VBG	VBG	_	3	amod	_	_
2	growth	growth	NN	NN	_	3	compound	_	_
3	factor-beta	factor-beta	NN	NN	_	4	nsubj	_	_
4	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	B	b	NN	NN	_	9	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
8	Ig	ig	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	4	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	inhibiting	inhibit	VBG	VBG	_	4	advcl	_	_
12	synthesis	synthesis	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	switch	switch	NN	NN	_	12	conj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	membrane	membrane	NN	NN	_	19	compound	_	_
19	form	form	NN	NN	_	15	nmod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	secreted	secreted	JJ	JJ	_	23	amod	_	_
23	form	form	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	Ig	ig	NN	NN	_	26	dep	_	_
26	mRNA	mrna	NN	NN	_	15	acl	_	_
27	.	.	.	.	_	4	punct	_	_

1	Transforming	transform	VBG	VBG	_	3	amod	_	_
2	growth	growth	NN	NN	_	3	compound	_	_
3	factor-beta	factor-beta	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TGF-beta	tgf-beta	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
8	B	b	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	Ig	ig	NN	NN	_	11	compound	_	_
11	secretion	secretion	NN	NN	_	7	dobj	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	reduces	reduce	VBZ	VBZ	_	7	conj	_	_
14	B	b	NN	NN	_	18	compound	_	_
15	cell	cell	NN	NN	_	18	compound	_	_
16	membrane	membrane	NN	NN	_	18	compound	_	_
17	Ig	ig	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	13	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TGF-beta	tgf-beta	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	cultures	culture	NNS	NNS	_	2	nmod	_	_
10	stimulated	stimulate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	16	case	_	_
12	Staphylococcus	staphylococcus	FW	FW	_	16	compound	_	_
13	aureus	aureus	FW	FW	_	16	compound	_	_
14	Cowan	cowan	NN	NN	_	16	compound	_	_
15	strain	strain	NN	NN	_	16	compound	_	_
16	I	i	NN	NN	_	10	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-2	il-2	NN	NN	_	16	conj	_	_
19	completely	completely	RB	RB	_	20	advmod	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	B	b	NN	NN	_	24	compound	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	Ig	ig	NN	NN	_	24	compound	_	_
24	secretion	secretion	NN	NN	_	20	dobj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	greater	greater	JJR	JJR	_	20	dep	_	_
27	than	than	IN	IN	_	29	case	_	_
28	90	90	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	26	nmod	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	and	and	CC	CC	_	20	cc	_	_
32	decreased	decrease	VBD	VBD	_	20	conj	_	_
33	B	b	NN	NN	_	48	compound	_	_
34	cell	cell	NN	NN	_	48	compound	_	_
35	surface	surface	NN	NN	_	48	compound	_	_
36	IgM	igm	NN	NN	_	48	compound	_	_
37	,	,	,	,	_	36	punct	_	_
38	IgD	igd	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	kappa	kappa	NN	NN	_	42	compound	_	_
41	L	l	NN	NN	_	42	compound	_	_
42	chain	chain	NN	NN	_	36	conj	_	_
43	,	,	,	,	_	36	punct	_	_
44	and	and	CC	CC	_	36	cc	_	_
45	lambda	lambda	NN	NN	_	47	compound	_	_
46	L	l	NN	NN	_	47	compound	_	_
47	chain	chain	NN	NN	_	36	conj	_	_
48	expression	expression	NN	NN	_	32	dobj	_	_
49	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	TGF-beta	tgf-beta	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	minimal	minimal	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	5	dobj	_	_
9	on	on	IN	IN	_	15	case	_	_
10	two	two	CD	CD	_	15	nummod	_	_
11	other	other	JJ	JJ	_	15	amod	_	_
12	B	b	NN	NN	_	15	compound	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	membrane	membrane	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	5	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	HLA-DR	hla-dr	NN	NN	_	15	appos	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	CD20	cd20	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Internal	internal	JJ	JJ	_	2	amod	_	_
2	labeling	labeling	NN	NN	_	15	nsubj	_	_
3	with	with	IN	IN	_	4	case	_	_
4	-LSB-35S-RSB-methionine	-lsb-35s-rsb-methionine	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	immunoprecipitation	immunoprecipitation	NN	NN	_	2	conj	_	_
7	with	with	IN	IN	_	14	case	_	_
8	anti-IgM	anti-igm	JJ	JJ	_	14	amod	_	_
9	,	,	,	,	_	8	punct	_	_
10	anti-kappa	anti-kappa	JJ	JJ	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	anti-lambda	anti-lambda	JJ	JJ	_	8	conj	_	_
14	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
15	revealed	reveal	VBD	VBD	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	striking	striking	JJ	JJ	_	18	amod	_	_
18	reduction	reduction	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	L	l	NN	NN	_	22	compound	_	_
22	chain	chain	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	dep	_	_
25	presence	presence	NN	NN	_	27	dep	_	_
26	of	of	IN	IN	_	27	case	_	_
27	TGF-beta	tgf-beta	NN	NN	_	18	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	less	less	RBR	RBR	_	3	advmod	_	_
3	pronounced	pronounced	JJ	JJ	_	4	amod	_	_
4	reduction	reduction	NN	NN	_	14	nsubjpass	_	_
5	in	in	IN	IN	_	8	case	_	_
6	lambda	lambda	NN	NN	_	8	compound	_	_
7	L	l	NN	NN	_	8	compound	_	_
8	chain	chain	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	microH	microh	NN	NN	_	11	compound	_	_
11	chain	chain	NN	NN	_	8	conj	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	noted	note	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	RNA	rna	NN	NN	_	3	nmod	_	_
6	purified	purify	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	treated	treat	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	TGF-beta	tgf-beta	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	varying	vary	VBG	VBG	_	16	amod	_	_
15	time	time	NN	NN	_	16	compound	_	_
16	intervals	interval	NNS	NNS	_	10	nmod	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	significant	significant	JJ	JJ	_	20	amod	_	_
20	decrease	decrease	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	steady	steady	JJ	JJ	_	24	amod	_	_
23	state	state	NN	NN	_	24	compound	_	_
24	kappa	kappa	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	lambda	lambda	NN	NN	_	30	compound	_	_
27	L	l	NN	NN	_	30	compound	_	_
28	chain	chain	NN	NN	_	30	compound	_	_
29	mRNA	mrna	NN	NN	_	30	compound	_	_
30	levels	level	NNS	NNS	_	24	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	Furthermore	furthermore	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	decrease	decrease	NN	NN	_	23	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	switch	switch	NN	NN	_	5	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	membrane	membrane	NN	NN	_	12	compound	_	_
12	forms	form	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	mu	mu	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	gamma	gamma	NN	NN	_	14	conj	_	_
17	to	to	TO	TO	_	21	case	_	_
18	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
19	respective	respective	JJ	JJ	_	21	amod	_	_
20	secreted	secreted	JJ	JJ	_	21	amod	_	_
21	forms	form	NNS	NNS	_	8	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	noted	note	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	dep	_	_
26	presence	presence	NN	NN	_	28	dep	_	_
27	of	of	IN	IN	_	28	case	_	_
28	TGF-beta	tgf-beta	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	23	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	decreased	decrease	VBN	VBN	_	6	amod	_	_
6	transcription	transcription	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	L	l	NN	NN	_	10	compound	_	_
10	chain	chain	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	30	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TGF-beta	tgf-beta	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	9	case	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	2	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	Oct-2	oct-2	NN	NN	_	9	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NF	nf	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	11	conj	_	_
20	,	,	,	,	_	9	punct	_	_
21	known	know	VBN	VBN	_	9	acl	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	important	important	JJ	JJ	_	21	xcomp	_	_
25	in	in	IN	IN	_	28	case	_	_
26	Ig	ig	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	transcription	transcription	NN	NN	_	24	nmod	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	examined	examine	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	Oct-2	oct-2	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	16	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	both	both	DT	DT	_	6	cc:preconj	_	_
6	Oct-2	oct-2	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	conj	_	_
10	proteins	protein	NNS	NNS	_	3	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	3	nmod	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	altered	alter	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	treatment	treatment	NN	NN	_	16	nmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	TGF-beta	tgf-beta	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	25	nmod	_	_
3	,	,	,	,	_	25	punct	_	_
4	levels	level	NNS	NNS	_	25	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	AP-1	ap-1	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	known	know	VBN	VBN	_	9	acl:relcl	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	important	important	JJ	JJ	_	14	xcomp	_	_
18	in	in	IN	IN	_	22	case	_	_
19	B	b	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	Ig	ig	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	9	punct	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	reduced	reduce	VBN	VBN	_	0	root	_	_
26	by	by	IN	IN	_	27	case	_	_
27	TGF-beta	tgf-beta	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TGF-beta	tgf-beta	NN	NN	_	6	nsubj	_	_
6	decreases	decrease	VBZ	VBZ	_	3	ccomp	_	_
7	B	b	NN	NN	_	10	compound	_	_
8	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
9	Ig	ig	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	6	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	synthesis	synthesis	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Ig	ig	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	inhibiting	inhibit	VBG	VBG	_	12	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	switch	switch	NN	NN	_	19	dobj	_	_
22	from	from	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	membrane	membrane	NN	NN	_	25	compound	_	_
25	form	form	NN	NN	_	21	nmod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	secreted	secreted	JJ	JJ	_	29	amod	_	_
29	forms	form	NNS	NNS	_	21	nmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	mu	mu	NN	NN	_	34	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	gamma	gamma	NN	NN	_	31	conj	_	_
34	mRNA	mrna	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	11	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	TGF-beta	tgf-beta	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	2	acl:relcl	_	_
7	Ig	ig	NN	NN	_	9	compound	_	_
8	chain	chain	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	6	dobj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	unclear	unclear	JJ	JJ	_	0	root	_	_
12	although	although	IN	IN	_	16	mark	_	_
13	it	it	PRP	PRP	_	16	nsubj	_	_
14	does	do	VBZ	VBZ	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	involve	involve	VB	VB	_	11	advcl	_	_
17	inhibition	inhibition	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	binding	binding	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	Oct-2	oct-2	NN	NN	_	23	conj	_	_
26	to	to	TO	TO	_	30	case	_	_
27	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
28	respective	respective	JJ	JJ	_	30	amod	_	_
29	target	target	NN	NN	_	30	compound	_	_
30	sequences	sequence	NNS	NNS	_	20	nmod	_	_
31	.	.	.	.	_	11	punct	_	_

1	Differentiation-associated	differentiation-associated	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
6	virus	virus	NN	NN	_	9	compound	_	_
7	BZLF1	bzlf1	NN	NN	_	9	compound	_	_
8	transactivator	transactivator	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	oral	oral	JJ	JJ	_	13	amod	_	_
12	hairy	hairy	JJ	JJ	_	13	amod	_	_
13	leukoplakia	leukoplakia	NN	NN	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	BZLF1	bzlf1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
6	virus	virus	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EBV	ebv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	key	key	JJ	JJ	_	14	amod	_	_
13	immediate-early	immediate-early	JJ	JJ	_	14	amod	_	_
14	protein	protein	NN	NN	_	0	root	_	_
15	which	which	WDT	WDT	_	18	nsubjpass	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	14	acl:relcl	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	disrupt	disrupt	VB	VB	_	18	xcomp	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	latency	latency	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	EBV-infected	ebv-infected	JJ	JJ	_	26	amod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	monoclonal	monoclonal	JJ	JJ	_	6	amod	_	_
6	antibody	antibody	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	BZ1	bz1	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	to	to	TO	TO	_	11	case	_	_
11	BZLF1	bzlf1	NN	NN	_	6	nmod	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	reacts	react	VBZ	VBZ	_	6	acl:relcl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	immunohistology	immunohistology	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	immunoblotting	immunoblotting	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	immunoprecipitation	immunoprecipitation	NN	NN	_	15	conj	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	recognizes	recognize	VBZ	VBZ	_	13	conj	_	_
24	both	both	CC	CC	_	29	cc:preconj	_	_
25	the	the	DT	DT	_	29	det	_	_
26	active	active	JJ	JJ	_	29	amod	_	_
27	,	,	,	,	_	26	punct	_	_
28	dimeric	dimeric	JJ	JJ	_	26	dep	_	_
29	form	form	NN	NN	_	23	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	35	det	_	_
32	inactive	inactive	JJ	JJ	_	35	amod	_	_
33	,	,	,	,	_	32	punct	_	_
34	monomeric	monomeric	JJ	JJ	_	32	dep	_	_
35	form	form	NN	NN	_	29	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	protein	protein	NN	NN	_	29	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Biopsies	biopsy	NNS	NNS	_	17	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	oral	oral	JJ	JJ	_	5	amod	_	_
4	hairy	hairy	JJ	JJ	_	5	amod	_	_
5	leukoplakia	leukoplakia	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	an	a	DT	DT	_	9	det	_	_
8	AIDS-associated	aids-associated	JJ	JJ	_	9	amod	_	_
9	lesion	lesion	NN	NN	_	5	appos	_	_
10	characterized	characterize	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	high-level	high-level	JJ	JJ	_	14	amod	_	_
13	EBV	ebv	NN	NN	_	14	compound	_	_
14	replication	replication	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	examined	examine	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	case	_	_
19	immunohistochemistry	immunohistochemistry	NN	NN	_	17	nmod	_	_
20	using	use	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	BZ1	bz1	NN	NN	_	24	compound	_	_
23	monoclonal	monoclonal	JJ	JJ	_	24	amod	_	_
24	antibody	antibody	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	differentiation-associated	differentiation-associated	JJ	JJ	_	3	amod	_	_
3	pattern	pattern	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	BZLF1	bzlf1	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	BZ1	bz1	NN	NN	_	11	nsubj	_	_
11	reacting	react	VBG	VBG	_	8	dep	_	_
12	with	with	IN	IN	_	13	case	_	_
13	nuclei	nucleus	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	upper	upper	JJ	JJ	_	18	amod	_	_
17	spinous	spinous	JJ	JJ	_	18	amod	_	_
18	layer	layer	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	lesion	lesion	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	BZLF1	bzlf1	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	degree	degree	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	squamous	squamous	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	comparison	comparison	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	situ	situ	FW	FW	_	4	dep	_	_
6	hybridization	hybridization	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	EBV	ebv	NN	NN	_	9	compound	_	_
9	DNA	dna	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	viral	viral	JJ	JJ	_	13	amod	_	_
12	capsid	capsid	NN	NN	_	13	compound	_	_
13	antigen	antigen	NN	NN	_	6	conj	_	_
14	staining	stain	VBG	VBG	_	13	amod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	BZ1	bz1	NN	NN	_	17	compound	_	_
17	reactivity	reactivity	NN	NN	_	2	nmod	_	_
18	suggested	suggest	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	BZLF1	bzlf1	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	22	nsubj	_	_
22	precedes	precede	VBZ	VBZ	_	18	ccomp	_	_
23	rampant	rampant	JJ	JJ	_	25	amod	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	replication	replication	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inability	inability	NN	NN	_	15	nsubj	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	detect	detect	VB	VB	_	2	acl	_	_
5	EBV	ebv	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	lower	lower	RBR	RBR	_	10	advmod	_	_
9	epithelial	epithelial	JJ	JJ	_	10	amod	_	_
10	layers	layer	NNS	NNS	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	oral	oral	JJ	JJ	_	14	amod	_	_
13	hairy	hairy	JJ	JJ	_	14	amod	_	_
14	leukoplakia	leukoplakia	NN	NN	_	10	nmod	_	_
15	raises	raise	VBZ	VBZ	_	0	root	_	_
16	questions	question	NNS	NNS	_	15	dobj	_	_
17	concerning	concern	VBG	VBG	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	nature	nature	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	EBV	ebv	NN	NN	_	19	nmod	_	_
22	latency	latency	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	persistence	persistence	NN	NN	_	22	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	stratified	stratified	JJ	JJ	_	28	amod	_	_
27	squamous	squamous	JJ	JJ	_	28	amod	_	_
28	epithelium	epithelium	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	Transactivation	transactivation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	herpesvirus	herpesvirus	NN	NN	_	1	nmod	_	_
11	6	6	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	HHV-6	hhv-6	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	strains	strain	VBZ	VBZ	_	10	dep	_	_
16	GS	gs	NN	NN	_	10	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Z-29	z-29	NN	NN	_	16	conj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	primary	primary	JJ	JJ	_	23	amod	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
24	and	and	CC	CC	_	1	cc	_	_
25	identification	identification	NN	NN	_	1	conj	_	_
26	of	of	IN	IN	_	33	case	_	_
27	transactivating	transactivate	VBG	VBG	_	33	amod	_	_
28	HHV-6	hhv-6	NN	NN	_	33	compound	_	_
29	(	(	-LRB-	-LRB-	_	33	punct	_	_
30	GS	gs	NN	NN	_	33	compound	_	_
31	)	)	-RRB-	-RRB-	_	33	punct	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	fragments	fragment	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	herpesvirus	herpesvirus	NN	NN	_	8	nsubj	_	_
3	6	6	CD	CD	_	2	nummod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	HHV-6	hhv-6	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	activate	activate	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	16	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HIV	hiv	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	promoter	promoter	NN	NN	_	8	dobj	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	accelerate	accelerate	VB	VB	_	8	conj	_	_
19	cytopathic	cytopathic	JJ	JJ	_	20	amod	_	_
20	effects	effect	NNS	NNS	_	18	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	HIV-infected	hiv-infected	JJ	JJ	_	25	amod	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	8	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	examines	examine	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regions	region	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HIV	hiv	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	required	require	VBN	VBN	_	5	acl	_	_
11	for	for	IN	IN	_	13	case	_	_
12	HHV-6	hhv-6	NN	NN	_	13	compound	_	_
13	transactivation	transactivation	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	heterogeneous	heterogeneous	JJ	JJ	_	17	amod	_	_
17	population	population	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	primary	primary	JJ	JJ	_	22	amod	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
23	with	with	IN	IN	_	27	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	without	without	IN	IN	_	23	conj	_	_
26	antigenic	antigenic	JJ	JJ	_	27	amod	_	_
27	stimulation	stimulation	NN	NN	_	13	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	strains	strain	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HHV-6	hhv-6	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	GS	gs	NN	NN	_	3	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Z29	z29	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	transactivated	transactivate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GS	gs	NN	NN	_	3	compound	_	_
3	strain	strain	NN	NN	_	4	nsubj	_	_
4	transactivated	transactivate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	promoter	promoter	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	13	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	stimulated	stimulate	VBN	VBN	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	resting	rest	VBG	VBG	_	9	conj	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	while	while	IN	IN	_	19	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	Z29	z29	NN	NN	_	18	compound	_	_
18	strain	strain	NN	NN	_	19	nsubj	_	_
19	increased	increase	VBD	VBD	_	4	advcl	_	_
20	HIV	hiv	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	dobj	_	_
23	only	only	RB	RB	_	27	advmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	stimulated	stimulate	VBN	VBN	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	11	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	HHV-6	hhv-6	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	GS	gs	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	genomic	genomic	JJ	JJ	_	10	amod	_	_
10	fragments	fragment	NNS	NNS	_	4	dobj	_	_
11	transactivated	transactivate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	cotransfected	cotransfect	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	21.4-kb	21.4-kb	JJ	JJ	_	4	amod	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	clone	clone	NN	NN	_	8	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	pZVB70	pzvb70	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	highest	highest	JJS	JJS	_	12	amod	_	_
11	transactivating	transactivating	NN	NN	_	12	compound	_	_
12	ability	ability	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	8	punct	_	_
14	while	while	IN	IN	_	32	mark	_	_
15	two	two	CD	CD	_	18	nummod	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	fragments	fragment	NNS	NNS	_	32	nsubj	_	_
19	,	,	,	,	_	18	punct	_	_
20	pZVB10	pzvb10	NN	NN	_	18	appos	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	6.2	6.2	CD	CD	_	23	nummod	_	_
23	kb	kb	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	pZVH14	pzvh14	NN	NN	_	20	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	8.7	8.7	CD	CD	_	29	nummod	_	_
29	kb	kb	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	18	punct	_	_
32	showed	show	VBD	VBD	_	8	advcl	_	_
33	lower	lower	JJR	JJR	_	34	amod	_	_
34	activity	activity	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	clones	clone	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	pZVH14	pzvh14	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	1	punct	_	_
8	activated	activate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	HIV	hiv	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	construct	construct	NN	NN	_	8	dobj	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	mutation	mutation	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	NF	nf	NN	NN	_	21	compound	_	_
19	kappa	kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	this	this	DT	DT	_	8	det	_	_
4	mutated	mutate	VBN	VBN	_	8	amod	_	_
5	NF	nf	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	11	nsubjpass	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	transactivated	transactivate	VBN	VBN	_	0	root	_	_
12	during	during	IN	IN	_	17	case	_	_
13	HHV-6	hhv-6	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	GS	gs	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	infection	infection	NN	NN	_	11	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	after	after	IN	IN	_	20	case	_	_
20	cotransfection	cotransfection	NN	NN	_	17	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	pZVB70	pzvb70	NN	NN	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	pZVB10	pzvb10	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	NF	nf	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	15	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	essential	essential	JJ	JJ	_	3	ccomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	transactivation	transactivation	NN	NN	_	15	nmod	_	_
19	during	during	IN	IN	_	24	case	_	_
20	HHV-6	hhv-6	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	GS	gs	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	infection	infection	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	increasing	increase	VBG	VBG	_	14	advcl	_	_
3	HIV	hiv	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	HHV-6	hhv-6	NN	NN	_	14	nsubj	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	consequently	consequently	RB	RB	_	14	advmod	_	_
14	increase	increase	VB	VB	_	0	root	_	_
15	HIV	hiv	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	14	punct	_	_
18	leading	lead	VBG	VBG	_	14	advcl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cytopathic	cytopathic	JJ	JJ	_	25	amod	_	_
25	effect	effect	NN	NN	_	21	nmod	_	_
26	on	on	IN	IN	_	30	case	_	_
27	coinfected	coinfect	VBN	VBN	_	30	amod	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	rhombotin	rhombotin	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	cysteine-rich	cysteine-rich	JJ	JJ	_	7	amod	_	_
6	LIM-domain	lim-domain	JJ	JJ	_	7	amod	_	_
7	oncogenes	oncogene	NNS	NNS	_	3	nmod	_	_
8	:	:	:	:	_	3	punct	_	_
9	distinct	distinct	JJ	JJ	_	10	amod	_	_
10	members	member	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	3	dep	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	translocations	translocation	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	chromosomes	chromosome	NNS	NNS	_	15	nmod	_	_
19	11p15	11p15	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	11p13	11p13	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	chromosomal	chromosomal	NN	NN	_	3	compound	_	_
3	translocation	translocation	NN	NN	_	19	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	leukemia	leukemia	NN	NN	_	3	nmod	_	_
8	involving	involve	VBG	VBG	_	3	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	short	short	JJ	JJ	_	11	amod	_	_
11	arm	arm	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	chromosome	chromosome	NN	NN	_	11	nmod	_	_
15	11	11	CD	CD	_	14	nummod	_	_
16	at	at	IN	IN	_	18	case	_	_
17	band	band	NN	NN	_	18	compound	_	_
18	11p15	11p15	NN	NN	_	11	nmod	_	_
19	disrupts	disrupt	VBZ	VBZ	_	0	root	_	_
20	the	the	DT	DT	_	22	det	_	_
21	rhombotin	rhombotin	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	19	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	encodes	encode	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	protein	protein	NN	NN	_	3	dobj	_	_
6	with	with	IN	IN	_	9	case	_	_
7	duplicated	duplicated	JJ	JJ	_	9	amod	_	_
8	cysteine-rich	cysteine-rich	JJ	JJ	_	9	amod	_	_
9	regions	region	NNS	NNS	_	5	nmod	_	_
10	called	call	VBN	VBN	_	9	acl	_	_
11	LIM	lim	NN	NN	_	12	compound	_	_
12	domains	domain	NNS	NNS	_	10	xcomp	_	_
13	,	,	,	,	_	9	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	show	show	VBP	VBP	_	9	acl:relcl	_	_
16	homology	homology	NN	NN	_	15	dobj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	zinc-binding	zinc-binding	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	to	to	TO	TO	_	23	case	_	_
22	iron-sulfur	iron-sulfur	JJ	JJ	_	23	amod	_	_
23	centers	center	NNS	NNS	_	19	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	ferredoxins	ferredoxin	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	homologues	homologue	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	rhombotin	rhombotin	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	have	have	VBP	VBP	_	10	aux	_	_
8	now	now	RB	RB	_	10	advmod	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	isolated	isolate	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	One	one	CD	CD	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	,	,	,	,	_	1	punct	_	_
5	designated	designate	VBN	VBN	_	1	acl	_	_
6	Rhom-2	rhom-2	NN	NN	_	5	xcomp	_	_
7	,	,	,	,	_	1	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	located	located	JJ	JJ	_	0	root	_	_
10	on	on	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	chromosome	chromosome	NN	NN	_	9	nmod	_	_
13	11	11	CD	CD	_	12	nummod	_	_
14	at	at	IN	IN	_	16	case	_	_
15	band	band	NN	NN	_	16	compound	_	_
16	11p13	11p13	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	where	where	WRB	WRB	_	25	advmod	_	_
19	a	a	DT	DT	_	20	det	_	_
20	cluster	cluster	NN	NN	_	25	nsubj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	T-cell	t-cell	NN	NN	_	24	compound	_	_
23	leukemia-specific	leukemia-specific	JJ	JJ	_	24	amod	_	_
24	translocations	translocation	NNS	NNS	_	20	nmod	_	_
25	occur	occur	VBP	VBP	_	12	acl:relcl	_	_
26	;	;	:	:	_	9	punct	_	_
27	all	all	DT	DT	_	29	det	_	_
28	translocation	translocation	NN	NN	_	29	compound	_	_
29	breakpoints	breakpoint	NNS	NNS	_	33	nsubj	_	_
30	at	at	IN	IN	_	31	case	_	_
31	11p13	11p13	NN	NN	_	29	nmod	_	_
32	are	be	VBP	VBP	_	33	cop	_	_
33	upstream	upstream	JJ	JJ	_	9	parataxis	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	Rhom-2	rhom-2	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	33	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	mouse	mouse	NN	NN	_	1	conj	_	_
4	Rhom-2	rhom-2	NN	NN	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	conserved	conserve	VBN	VBN	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	,	,	,	,	_	7	punct	_	_
10	like	like	IN	IN	_	11	case	_	_
11	rhombotin	rhombotin	NN	NN	_	13	nmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	encode	encode	VBP	VBP	_	7	conj	_	_
14	two	two	CD	CD	_	18	nummod	_	_
15	tandem	tandem	JJ	JJ	_	18	amod	_	_
16	cysteine-rich	cysteine-rich	JJ	JJ	_	18	amod	_	_
17	LIM	lim	NN	NN	_	18	compound	_	_
18	domains	domain	NNS	NNS	_	13	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	Rhom-2	rhom-2	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	early	early	JJ	JJ	_	8	amod	_	_
7	mouse	mouse	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	central	central	JJ	JJ	_	12	amod	_	_
11	nervous	nervous	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	lung	lung	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	kidney	kidney	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	liver	liver	NN	NN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	spleen	spleen	NN	NN	_	12	conj	_	_
22	but	but	CC	CC	_	4	cc	_	_
23	only	only	RB	RB	_	25	advmod	_	_
24	very	very	RB	RB	_	25	advmod	_	_
25	low	low	JJ	JJ	_	26	amod	_	_
26	levels	level	NNS	NNS	_	27	nsubj	_	_
27	occur	occur	VBP	VBP	_	4	conj	_	_
28	in	in	IN	IN	_	29	case	_	_
29	thymus	thymus	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	gene	gene	NN	NN	_	11	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	designated	designate	VBN	VBN	_	3	acl	_	_
6	Rhom-3	rhom-3	NN	NN	_	5	xcomp	_	_
7	,	,	,	,	_	3	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	on	on	IN	IN	_	11	case	_	_
11	chromosome	chromosome	NN	NN	_	0	root	_	_
12	11	11	CD	CD	_	11	nummod	_	_
13	but	but	CC	CC	_	11	cc	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	retains	retain	VBZ	VBZ	_	11	conj	_	_
16	homology	homology	NN	NN	_	15	dobj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	LIM	lim	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	rhombotin	rhombotin	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	Rhom-2	rhom-2	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	such	such	JJ	JJ	_	9	amod	_	_
7	a	a	DT	DT	_	9	det	_	_
8	common	common	JJ	JJ	_	9	amod	_	_
9	site	site	NN	NN	_	27	advcl	_	_
10	of	of	IN	IN	_	12	case	_	_
11	chromosomal	chromosomal	JJ	JJ	_	12	amod	_	_
12	damage	damage	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	tumors	tumor	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	27	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	consistency	consistency	NN	NN	_	27	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	translocations	translocation	NNS	NNS	_	18	nmod	_	_
21	near	near	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	rhombotin	rhombotin	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	20	nmod	_	_
25	was	be	VBD	VBD	_	27	auxpass	_	_
26	further	further	RB	RB	_	27	advmod	_	_
27	examined	examine	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	8	nsubj	_	_
4	adjacent	adjacent	JJ	JJ	_	3	amod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	rhombotin	rhombotin	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	at	at	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	same	same	JJ	JJ	_	13	amod	_	_
13	position	position	NN	NN	_	8	conj	_	_
14	as	as	IN	IN	_	18	case	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	previous	previous	JJ	JJ	_	18	amod	_	_
18	example	example	NN	NN	_	13	acl	_	_
19	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	chromosome	chromosome	NN	NN	_	4	compound	_	_
4	bands	band	NNS	NNS	_	16	nsubj	_	_
5	11p15	11p15	NN	NN	_	4	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	rhombotin	rhombotin	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	11p13	11p13	NN	NN	_	5	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Rhom-2	rhom-2	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	are	be	VBP	VBP	_	16	cop	_	_
15	consistent	consistent	JJ	JJ	_	16	amod	_	_
16	sites	site	NNS	NNS	_	0	root	_	_
17	of	of	IN	IN	_	19	case	_	_
18	chromosome	chromosome	NN	NN	_	19	compound	_	_
19	translocation	translocation	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	leukemia	leukemia	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	with	with	IN	IN	_	30	mark	_	_
25	the	the	DT	DT	_	27	det	_	_
26	11p15	11p15	NN	NN	_	27	compound	_	_
27	target	target	NN	NN	_	30	nsubj	_	_
28	more	more	RBR	RBR	_	29	advmod	_	_
29	rarely	rarely	RB	RB	_	30	advmod	_	_
30	involved	involve	VBN	VBN	_	16	advcl	_	_
31	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	define	define	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	rhombotin	rhombotin	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	3	dobj	_	_
8	as	as	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	class	class	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	oncogenes	oncogene	NNS	NNS	_	10	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	duplicated	duplicated	JJ	JJ	_	18	amod	_	_
16	cysteine-rich	cysteine-rich	JJ	JJ	_	18	amod	_	_
17	LIM	lim	NN	NN	_	18	compound	_	_
18	domains	domain	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	myelomonocytic	myelomonocytic	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	U-937	u-937	NN	NN	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	model	model	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	studying	study	VBG	VBG	_	9	acl	_	_
12	alterations	alteration	NNS	NNS	_	11	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	steroid-induced	steroid-induced	JJ	JJ	_	17	amod	_	_
15	monokine	monokine	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	12	nmod	_	_
18	:	:	:	:	_	6	punct	_	_
19	marked	marked	JJ	JJ	_	20	amod	_	_
20	enhancement	enhancement	NN	NN	_	6	dep	_	_
21	of	of	IN	IN	_	27	case	_	_
22	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	27	amod	_	_
23	interleukin-1	interleukin-1	NN	NN	_	27	compound	_	_
24	beta	beta	NN	NN	_	27	compound	_	_
25	messenger	messenger	NN	NN	_	27	compound	_	_
26	RNA	rna	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	20	nmod	_	_
28	by	by	IN	IN	_	30	case	_	_
29	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	30	compound	_	_
30	D3	d3	NN	NN	_	20	nmod	_	_
31	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	metabolite	metabolite	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	vitamin	vitamin	NN	NN	_	6	compound	_	_
6	D	d	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	6	appos	_	_
10	-LSB-	-lsb-	-LRB-	-LRB-	_	11	punct	_	_
11	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	9	appos	_	_
12	-RSB-	-rsb-	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	17	punct	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	potent	potent	JJ	JJ	_	17	amod	_	_
17	regulator	regulator	NN	NN	_	0	root	_	_
18	of	of	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	monocyte/macrophage	monocyte/macrophage	JJ	JJ	_	21	amod	_	_
21	function	function	NN	NN	_	17	nmod	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	17	advmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	establish	establish	VB	VB	_	27	advcl	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	monocyte	monocyte	NN	NN	_	12	compound	_	_
11	monokine	monokine	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	27	punct	_	_
14	three	three	CD	CD	_	17	nummod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	27	nsubjpass	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	U-937	u-937	NN	NN	_	17	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	THP-1	thp-1	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	HL-60	hl-60	NN	NN	_	19	conj	_	_
25	)	)	-RRB-	-RRB-	_	19	punct	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	examined	examine	VBN	VBN	_	0	root	_	_
28	for	for	IN	IN	_	33	case	_	_
29	:	:	:	:	_	33	punct	_	_
30	1	1	LS	LS	_	33	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	the	the	DT	DT	_	33	det	_	_
33	presence	presence	NN	NN	_	27	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	functional	functional	JJ	JJ	_	37	amod	_	_
36	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	37	compound	_	_
37	receptors	receptor	NNS	NNS	_	33	nmod	_	_
38	;	;	:	:	_	33	punct	_	_
39	2	2	LS	LS	_	42	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	the	the	DT	DT	_	42	det	_	_
42	accumulation	accumulation	NN	NN	_	33	conj	_	_
43	of	of	IN	IN	_	50	case	_	_
44	interleukin-1	interleukin-1	NN	NN	_	45	compound	_	_
45	beta	beta	NN	NN	_	50	compound	_	_
46	(	(	-LRB-	-LRB-	_	48	punct	_	_
47	IL-1	il-1	NN	NN	_	48	compound	_	_
48	beta	beta	NN	NN	_	45	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	mRNA	mrna	NN	NN	_	42	nmod	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	IL-1	il-1	NN	NN	_	54	compound	_	_
53	beta	beta	NN	NN	_	54	compound	_	_
54	protein	protein	NN	NN	_	50	conj	_	_
55	in	in	IN	IN	_	58	case	_	_
56	response	response	NN	NN	_	58	dep	_	_
57	to	to	TO	TO	_	58	case	_	_
58	lipopolysaccharide	lipopolysaccharide	NN	NN	_	42	nmod	_	_
59	(	(	-LRB-	-LRB-	_	60	punct	_	_
60	LPS	lps	NN	NN	_	58	appos	_	_
61	)	)	-RRB-	-RRB-	_	60	punct	_	_
62	;	;	:	:	_	33	punct	_	_
63	and	and	CC	CC	_	33	cc	_	_
64	3	3	LS	LS	_	67	dep	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	the	the	DT	DT	_	67	det	_	_
67	regulation	regulation	NN	NN	_	33	conj	_	_
68	of	of	IN	IN	_	70	case	_	_
69	this	this	DT	DT	_	70	det	_	_
70	response	response	NN	NN	_	67	nmod	_	_
71	by	by	IN	IN	_	72	case	_	_
72	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	67	nmod	_	_
73	.	.	.	.	_	27	punct	_	_

1	All	all	DT	DT	_	4	det	_	_
2	three	three	CD	CD	_	4	nummod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	vitamin	vitamin	NN	NN	_	8	compound	_	_
7	D	d	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	had	have	VBD	VBD	_	11	aux	_	_
11	increased	increase	VBN	VBN	_	5	conj	_	_
12	levels	level	NNS	NNS	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	IL-1	il-1	NN	NN	_	16	compound	_	_
15	beta	beta	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	response	response	NN	NN	_	20	dep	_	_
19	to	to	TO	TO	_	20	case	_	_
20	LPS	lps	NN	NN	_	11	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Preincubation	preincubation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	1	nmod	_	_
6	augmented	augment	VBD	VBD	_	0	root	_	_
7	IL-1	il-1	NN	NN	_	10	compound	_	_
8	beta	beta	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	6	dobj	_	_
11	only	only	RB	RB	_	16	advmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	U-937	u-937	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HL-60	hl-60	NN	NN	_	13	conj	_	_
16	cells	cell	NNS	NNS	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	21	dep	_	_
4	,	,	,	,	_	3	punct	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	taking	take	VBG	VBG	_	3	conj	_	_
7	into	into	IN	IN	_	8	case	_	_
8	consideration	consideration	NN	NN	_	6	nmod	_	_
9	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
10	state	state	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	differentiation	differentiation	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	relative	relative	JJ	JJ	_	15	amod	_	_
15	ease	ease	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	culture	culture	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	21	punct	_	_
19	U-937	u-937	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	chosen	choose	VBN	VBN	_	0	root	_	_
22	over	over	IN	IN	_	23	case	_	_
23	HL-60	hl-60	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	THP-1	thp-1	NN	NN	_	23	conj	_	_
26	as	as	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	21	nmod	_	_
30	we	we	PRP	PRP	_	32	nsubj	_	_
31	further	further	RB	RB	_	32	advmod	_	_
32	characterized	characterize	VBD	VBD	_	29	acl:relcl	_	_
33	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	U-937	u-937	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	optimum	optimum	JJ	JJ	_	6	amod	_	_
6	time	time	NN	NN	_	14	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	dose	dose	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	pretreatment	pretreatment	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	10	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	determined	determine	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	18	mark	_	_
16	be	be	VB	VB	_	18	cop	_	_
17	12-24	12-24	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	14	xcomp	_	_
19	at	at	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	receptor	receptor	NN	NN	_	23	compound	_	_
22	saturating	saturating	JJ	JJ	_	23	amod	_	_
23	concentration	concentration	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	10	10	CD	CD	_	28	nummod	_	_
28	nM	nm	NN	NN	_	23	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	14	punct	_	_

1	Preincubation	preincubation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	1	nmod	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	on	on	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	time	time	NN	NN	_	12	compound	_	_
12	course	course	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	IL-1	il-1	NN	NN	_	17	compound	_	_
15	beta	beta	NN	NN	_	17	compound	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	appearance	appearance	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	response	response	NN	NN	_	21	dep	_	_
20	to	to	TO	TO	_	21	case	_	_
21	LPS	lps	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	exposure	exposure	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	U-937	u-937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	3	nmod	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	200	200	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	9	nmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	9	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	IL-1	il-1	NN	NN	_	18	compound	_	_
17	beta	beta	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	14	nmod	_	_
19	detected	detect	VBD	VBD	_	18	acl	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	decreased	decrease	VBD	VBD	_	9	conj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	three	three	CD	CD	_	24	nummod	_	_
24	orders	order	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	magnitude	magnitude	NN	NN	_	24	nmod	_	_
27	the	the	DT	DT	_	28	det	_	_
28	concentration	concentration	NN	NN	_	21	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	LPS	lps	NN	NN	_	28	nmod	_	_
31	required	require	VBN	VBN	_	28	acl	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	achieve	achieve	VB	VB	_	31	xcomp	_	_
34	steady	steady	JJ	JJ	_	37	amod	_	_
35	state	state	NN	NN	_	37	compound	_	_
36	mRNA	mrna	NN	NN	_	37	compound	_	_
37	levels	level	NNS	NNS	_	33	dobj	_	_
38	equivalent	equivalent	JJ	JJ	_	37	amod	_	_
39	to	to	TO	TO	_	40	case	_	_
40	those	those	DT	DT	_	38	nmod	_	_
41	observed	observe	VBN	VBN	_	40	acl	_	_
42	in	in	IN	IN	_	44	case	_	_
43	U-937	u-937	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	41	nmod	_	_
45	not	not	RB	RB	_	46	neg	_	_
46	preincubated	preincubate	VBN	VBN	_	44	acl	_	_
47	with	with	IN	IN	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	hormone.2+o	hormone.2+o	NN	NN	_	46	nmod	_	_

1	Cortivazol	cortivazol	NN	NN	_	3	compound	_	_
2	mediated	mediate	VBD	VBD	_	3	amod	_	_
3	induction	induction	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
6	receptor	receptor	NN	NN	_	9	compound	_	_
7	messenger	messenger	NN	NN	_	9	compound	_	_
8	ribonucleic	ribonucleic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	19	case	_	_
11	wild-type	wild-type	JJ	JJ	_	19	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	dexamethasone-resistant	dexamethasone-resistant	JJ	JJ	_	11	conj	_	_
14	human	human	JJ	JJ	_	19	amod	_	_
15	leukemic	leukemic	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	CEM	cem	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	cells	cell	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Cortivazol	cortivazol	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	phenylpyrazolo	phenylpyrazolo	JJ	JJ	_	5	amod	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	potency	potency	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	unusual	unusual	JJ	JJ	_	11	amod	_	_
11	structure	structure	NN	NN	_	8	conj	_	_
12	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	11	case	_	_
2	both	both	CC	CC	_	3	cc:preconj	_	_
3	wild-type	wild-type	JJ	JJ	_	11	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	highly	highly	RB	RB	_	10	advmod	_	_
6	dexamethasone	dexamethasone	NN	NN	_	10	nmod:npmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	dex	dex	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	-resistant	-resistant	JJ	JJ	_	3	conj	_	_
11	clones	clone	NNS	NNS	_	23	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	leukemic	leukemic	JJ	JJ	_	18	amod	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	line	line	NN	NN	_	18	compound	_	_
18	CEM	cem	NN	NN	_	11	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	exposure	exposure	NN	NN	_	23	nsubj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	cortivazol	cortivazol	NN	NN	_	20	nmod	_	_
23	leads	lead	VBZ	VBZ	_	0	root	_	_
24	to	to	TO	TO	_	26	case	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	death	death	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	23	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	recently	recently	RB	RB	_	4	advmod	_	_
6	that	that	IN	IN	_	28	mark	_	_
7	in	in	IN	IN	_	10	case	_	_
8	wild-type	wild-type	JJ	JJ	_	10	amod	_	_
9	CEM	cem	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	28	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	25	neg	_	_
13	in	in	IN	IN	_	25	case	_	_
14	a	a	DT	DT	_	25	det	_	_
15	dex-resistant	dex-resistant	JJ	JJ	_	25	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	22	nmod:npmod	_	_
18	receptor	receptor	NN	NN	_	22	nmod:npmod	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	GR	gr	NN	NN	_	22	nmod:npmod	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	-defective	-defective	JJ	JJ	_	15	dep	_	_
23	clone	clone	NN	NN	_	25	compound	_	_
24	ICR-27	icr-27	NN	NN	_	25	compound	_	_
25	TK-3	tk-3	NN	NN	_	10	conj	_	_
26	,	,	,	,	_	28	punct	_	_
27	dex	dex	NN	NN	_	28	nsubj	_	_
28	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
29	GR	gr	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	28	dobj	_	_
31	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	cortivazol	cortivazol	NN	NN	_	7	nsubj	_	_
7	acts	act	VBZ	VBZ	_	4	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	dex-resistant	dex-resistant	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	making	make	VBG	VBG	_	7	advcl	_	_
13	use	use	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	residual	residual	JJ	JJ	_	17	amod	_	_
17	GR	gr	NN	NN	_	13	nmod	_	_
18	found	find	VBN	VBN	_	17	acl	_	_
19	there	there	RB	RB	_	18	advmod	_	_
20	,	,	,	,	_	2	punct	_	_
21	wild-type	wild-type	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	dex-resistant	dex-resistant	JJ	JJ	_	21	conj	_	_
24	clones	clone	NNS	NNS	_	26	nsubjpass	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	treated	treat	VBN	VBN	_	2	parataxis	_	_
27	with	with	IN	IN	_	29	case	_	_
28	various	various	JJ	JJ	_	29	amod	_	_
29	concentrations	concentration	NNS	NNS	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	cortivazol	cortivazol	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	26	cc	_	_
33	induction	induction	NN	NN	_	38	nsubjpass	_	_
34	of	of	IN	IN	_	36	case	_	_
35	GR	gr	NN	NN	_	36	compound	_	_
36	mRNA	mrna	NN	NN	_	33	nmod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	studied	study	VBN	VBN	_	26	conj	_	_
39	.	.	.	.	_	2	punct	_	_

1	Cortivazol	cortivazol	NN	NN	_	3	nsubj	_	_
2	significantly	significantly	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	normal	normal	JJ	JJ	_	9	amod	_	_
9	CEM-C7	cem-c7	NN	NN	_	5	nmod	_	_
10	as	as	RB	RB	_	9	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	in	in	IN	IN	_	15	case	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	classes	class	NNS	NNS	_	9	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	dex-resistant	dex-resistant	JJ	JJ	_	18	amod	_	_
18	clones	clone	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	although	although	IN	IN	_	24	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	dex-resistant	dex-resistant	JJ	JJ	_	23	amod	_	_
23	clones	clone	NNS	NNS	_	24	nsubj	_	_
24	needed	need	VBD	VBD	_	3	advcl	_	_
25	at	at	IN	IN	_	26	case	_	_
26	least	least	JJS	JJS	_	28	nmod:npmod	_	_
27	10	10	CD	CD	_	28	compound	_	_
28	times	time	NNS	NNS	_	30	dep	_	_
29	more	more	JJR	JJR	_	28	dep	_	_
30	cortivazol	cortivazol	NN	NN	_	24	dobj	_	_
31	than	than	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	normal	normal	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	for	for	IN	IN	_	39	case	_	_
36	significant	significant	JJ	JJ	_	39	amod	_	_
37	GR	gr	NN	NN	_	39	compound	_	_
38	mRNA	mrna	NN	NN	_	39	compound	_	_
39	induction	induction	NN	NN	_	24	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	noticed	notice	VBN	VBN	_	0	root	_	_
8	as	as	RB	RB	_	9	advmod	_	_
9	early	early	RB	RB	_	7	advmod	_	_
10	as	as	IN	IN	_	12	case	_	_
11	3	3	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	9	nmod	_	_
13	after	after	IN	IN	_	12	case	_	_
14	treatment	treatment	NN	NN	_	12	dep	_	_
15	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	general	general	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	18	nsubjpass	_	_
4	between	between	IN	IN	_	5	case	_	_
5	induction	induction	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	GR	gr	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	lysis	lysis	NN	NN	_	5	conj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	normal	normal	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	dex-resistant	dex-resistant	JJ	JJ	_	13	conj	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Positive	positive	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	might	might	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	one	one	CD	CD	_	0	root	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	earliest	earliest	JJS	JJS	_	13	amod	_	_
12	crucial	crucial	JJ	JJ	_	13	amod	_	_
13	steps	step	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	lysis	lysis	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	normal	normal	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	dex-resistant	dex-resistant	JJ	JJ	_	18	conj	_	_
21	CEM	cem	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	8	punct	_	_
24	or	or	CC	CC	_	8	cc	_	_
25	might	might	MD	MD	_	26	aux	_	_
26	serve	serve	VB	VB	_	8	conj	_	_
27	as	as	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	marker	marker	NN	NN	_	26	nmod	_	_
30	for	for	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	process	process	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	lysis	lysis	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	11	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	dex-resistant	dex-resistant	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	defective	defective	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	16	mark	_	_
13	that	that	IN	IN	_	16	mark	_	_
14	dex-resistant	dex-resistant	JJ	JJ	_	15	amod	_	_
15	clones	clone	NNS	NNS	_	16	nsubj	_	_
16	needed	need	VBD	VBD	_	11	advcl	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	more	more	JJR	JJR	_	19	amod	_	_
19	cortivazol	cortivazol	NN	NN	_	16	dobj	_	_
20	than	than	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	normal	normal	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	lysis	lysis	NN	NN	_	16	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	case	case	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	hypersensitivity	hypersensitivity	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	thyroid	thyroid	NN	NN	_	7	compound	_	_
7	hormones	hormone	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	normally	normally	RB	RB	_	12	advmod	_	_
10	functioning	function	VBG	VBG	_	12	dep	_	_
11	thyroid	thyroid	NN	NN	_	12	compound	_	_
12	gland	gland	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	increased	increase	VBN	VBN	_	17	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	triiodothyronine	triiodothyronine	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	12	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	52-year-old	52-year-old	JJ	JJ	_	3	amod	_	_
3	male	male	NN	NN	_	4	nsubj	_	_
4	presented	present	VBD	VBD	_	0	root	_	_
5	himself	himself	PRP	PRP	_	4	dobj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	tachycardia	tachycardia	NN	NN	_	8	compound	_	_
8	crises	crisis	NNS	NNS	_	4	nmod	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	appeared	appear	VBD	VBD	_	8	acl:relcl	_	_
11	first	first	RB	RB	_	10	advmod	_	_
12	during	during	IN	IN	_	13	case	_	_
13	childhood	childhood	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	increased	increase	VBD	VBD	_	10	dep	_	_
16	in	in	IN	IN	_	17	case	_	_
17	frequency	frequency	NN	NN	_	15	nmod	_	_
18	without	without	IN	IN	_	19	case	_	_
19	goiter	goiter	NN	NN	_	15	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	exophthalmos	exophthalmo	NNS	NNS	_	19	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Cardiac	cardiac	JJ	JJ	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	adrenergic	adrenergic	JJ	JJ	_	1	conj	_	_
4	diseases	disease	NNS	NNS	_	1	dep	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	excluded	exclude	VBN	VBN	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	thyroid	thyroid	NN	NN	_	3	compound	_	_
3	function	function	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	normal	normal	JJ	JJ	_	0	root	_	_
6	regarding	regard	VBG	VBG	_	7	case	_	_
7	T4	t4	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	free	free	JJ	JJ	_	10	amod	_	_
10	T4	t4	NN	NN	_	7	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T3	t3	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	7	punct	_	_
14	TBG	tbg	NN	NN	_	7	appos	_	_
15	,	,	,	,	_	7	punct	_	_
16	radioiodine	radioiodine	NN	NN	_	17	compound	_	_
17	uptake	uptake	NN	NN	_	7	appos	_	_
18	,	,	,	,	_	7	punct	_	_
19	TSH	tsh	NN	NN	_	7	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	T3	t3	NN	NN	_	19	conj	_	_
22	suppressibility	suppressibility	NN	NN	_	19	dep	_	_
23	;	;	:	:	_	5	punct	_	_
24	however	however	RB	RB	_	31	advmod	_	_
25	the	the	DT	DT	_	27	det	_	_
26	TSH	tsh	NN	NN	_	27	compound	_	_
27	response	response	NN	NN	_	31	nsubjpass	_	_
28	to	to	TO	TO	_	29	case	_	_
29	TRH	trh	NN	NN	_	27	nmod	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	decreased	decrease	VBN	VBN	_	5	parataxis	_	_
32	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	T3	t3	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	affinity	affinity	NN	NN	_	7	nmod	_	_
11	close	close	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	that	that	DT	DT	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	volunteers	volunteer	NNS	NNS	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Ka	ka	NN	NN	_	13	dep	_	_
19	:	:	:	:	_	18	punct	_	_
20	1.42	1.42	CD	CD	_	23	nummod	_	_
21	x	x	CC	CC	_	20	cc	_	_
22	10(10)	10(10)	CD	CD	_	20	conj	_	_
23	M-1	m-1	NN	NN	_	18	dep	_	_
24	vs	vs	CC	CC	_	23	cc	_	_
25	1.95	1.95	CD	CD	_	30	nummod	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	0.35	0.35	CD	CD	_	25	conj	_	_
28	x	x	CC	CC	_	27	cc	_	_
29	10(10)	10(10)	CD	CD	_	27	conj	_	_
30	M-1	m-1	NN	NN	_	23	conj	_	_
31	)	)	-RRB-	-RRB-	_	18	punct	_	_
32	and	and	CC	CC	_	7	cc	_	_
33	a	a	DT	DT	_	35	det	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	capacity	capacity	NN	NN	_	37	nsubj	_	_
36	markedly	markedly	RB	RB	_	37	advmod	_	_
37	increased	increase	VBD	VBD	_	7	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	9.9	9.9	CD	CD	_	37	dep	_	_
40	vs	vs	CC	CC	_	39	cc	_	_
41	3.7	3.7	CD	CD	_	39	conj	_	_
42	+/-	+/-	CC	CC	_	41	cc	_	_
43	0.4	0.4	CD	CD	_	41	conj	_	_
44	fmol	fmol	NN	NN	_	49	compound	_	_
45	T3	t3	NN	NN	_	49	compound	_	_
46	/	/	:	:	_	49	punct	_	_
47	100	100	CD	CD	_	49	nummod	_	_
48	micrograms	microgram	NNS	NNS	_	49	compound	_	_
49	DNA	dna	NN	NN	_	39	dep	_	_
50	)	)	-RRB-	-RRB-	_	39	punct	_	_
51	.	.	.	.	_	7	punct	_	_

1	Pindolol	pindolol	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	inefficient	inefficient	JJ	JJ	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	dysrhythmia	dysrhythmia	NN	NN	_	3	nmod	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	disappeared	disappear	VBD	VBD	_	6	acl:relcl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	carbimazole	carbimazole	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	relapsed	relapse	VBD	VBD	_	8	conj	_	_
13	after	after	IN	IN	_	14	case	_	_
14	withdrawal	withdrawal	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	antithyroid	antithyroid	NN	NN	_	18	compound	_	_
18	drug	drug	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Under	under	IN	IN	_	2	case	_	_
2	carbimazole	carbimazole	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	plasma	plasma	NN	NN	_	6	compound	_	_
6	T4	t4	NN	NN	_	8	nsubj	_	_
7	markedly	markedly	RB	RB	_	8	advmod	_	_
8	decreased	decrease	VBD	VBD	_	0	root	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	27.7	27.7	CD	CD	_	13	nummod	_	_
11	+/-	+/-	CC	CC	_	10	cc	_	_
12	3.6	3.6	CD	CD	_	10	conj	_	_
13	nmol/l	nmol/l	NN	NN	_	8	dep	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	but	but	CC	CC	_	8	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	patient	patient	NN	NN	_	18	nsubj	_	_
18	remained	remain	VBD	VBD	_	8	conj	_	_
19	euthyroid	euthyroid	NN	NN	_	18	xcomp	_	_
20	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	course	course	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	laboratory	laboratory	NN	NN	_	7	compound	_	_
7	data	datum	NNS	NNS	_	3	conj	_	_
8	suggest	suggest	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	tachycardia	tachycardia	NN	NN	_	12	compound	_	_
12	crises	crisis	NNS	NNS	_	15	nsubj	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	the	the	DT	DT	_	15	det	_	_
15	consequence	consequence	NN	NN	_	8	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	hypersensitivity	hypersensitivity	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	heart	heart	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	thyroid	thyroid	NN	NN	_	24	compound	_	_
24	hormones	hormone	NNS	NNS	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	associated	associate	VBN	VBN	_	24	acl	_	_
27	with	with	IN	IN	_	30	case	_	_
28	an	a	DT	DT	_	30	det	_	_
29	increased	increase	VBN	VBN	_	30	amod	_	_
30	number	number	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	T3	t3	NN	NN	_	35	compound	_	_
33	nuclear	nuclear	JJ	JJ	_	35	amod	_	_
34	receptor	receptor	NN	NN	_	35	compound	_	_
35	sites	site	NNS	NNS	_	30	nmod	_	_
36	in	in	IN	IN	_	37	case	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	35	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	alveolar	alveolar	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	pulmonary	pulmonary	JJ	JJ	_	13	amod	_	_
12	granulomatous	granulomatous	JJ	JJ	_	13	amod	_	_
13	diseases	disease	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	produced	produce	VBN	VBN	_	3	xcomp	_	_
7	at	at	IN	IN	_	8	case	_	_
8	sites	site	NNS	NNS	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	granulomatous	granulomatous	JJ	JJ	_	11	amod	_	_
11	reactions	reaction	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	characterize	characterize	VB	VB	_	18	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	types	type	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	targets	target	NNS	NNS	_	7	acl:relcl	_	_
11	for	for	IN	IN	_	14	case	_	_
12	this	this	DT	DT	_	14	det	_	_
13	immunoregulatory	immunoregulatory	JJ	JJ	_	14	amod	_	_
14	hormone	hormone	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	evaluated	evaluate	VBN	VBN	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	on	on	IN	IN	_	27	case	_	_
25	peripheral	peripheral	JJ	JJ	_	27	amod	_	_
26	blood	blood	NN	NN	_	27	compound	_	_
27	T-lymphocytes	t-lymphocyte	NNS	NNS	_	20	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	those	those	DT	DT	_	27	conj	_	_
30	recovered	recover	VBN	VBN	_	29	acl	_	_
31	from	from	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	lung	lung	NN	NN	_	30	nmod	_	_
34	by	by	IN	IN	_	36	case	_	_
35	bronchoalveolar	bronchoalveolar	JJ	JJ	_	36	amod	_	_
36	lavage	lavage	NN	NN	_	30	nmod	_	_
37	from	from	IN	IN	_	38	case	_	_
38	patients	patient	NNS	NNS	_	36	nmod	_	_
39	with	with	IN	IN	_	42	case	_	_
40	pulmonary	pulmonary	JJ	JJ	_	42	amod	_	_
41	granulomatous	granulomatous	JJ	JJ	_	42	amod	_	_
42	diseases	disease	NNS	NNS	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	tuberculosis	tuberculosis	NN	NN	_	42	dep	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	sarcoidosis	sarcoidosis	NN	NN	_	44	conj	_	_
47	)	)	-RRB-	-RRB-	_	44	punct	_	_
48	and	and	CC	CC	_	38	cc	_	_
49	from	from	IN	IN	_	52	case	_	_
50	normal	normal	JJ	JJ	_	52	amod	_	_
51	control	control	NN	NN	_	52	compound	_	_
52	subjects	subject	NNS	NNS	_	38	conj	_	_
53	using	use	VBG	VBG	_	30	xcomp	_	_
54	combined	combined	JJ	JJ	_	58	amod	_	_
55	autoradiographic	autoradiographic	JJ	JJ	_	58	amod	_	_
56	and	and	CC	CC	_	55	cc	_	_
57	immunohistochemical	immunohistochemical	JJ	JJ	_	55	conj	_	_
58	techniques	technique	NNS	NNS	_	53	dobj	_	_
59	.	.	.	.	_	18	punct	_	_

1	Lavage	lavage	NN	NN	_	2	compound	_	_
2	T-lymphocytes	t-lymphocyte	NNS	NNS	_	19	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	tuberculosis	tuberculosis	NN	NN	_	4	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	with	with	IN	IN	_	9	case	_	_
9	sarcoidosis	sarcoidosis	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	2	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	2	cc	_	_
13	those	those	DT	DT	_	2	conj	_	_
14	from	from	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	control	control	NN	NN	_	17	compound	_	_
17	subjects	subject	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	expressed	express	VBD	VBD	_	0	root	_	_
20	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	19	dobj	_	_
22	as	as	IN	IN	_	23	mark	_	_
23	demonstrated	demonstrate	VBN	VBN	_	19	advcl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	binding	binding	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	-LSB-3H-RSB-1,25(OH)2D3	-lsb-3h-rsb-1,25(oh)2d3	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	25	punct	_	_
29	which	which	WDT	WDT	_	31	nsubjpass	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	inhibited	inhibit	VBN	VBN	_	25	acl:relcl	_	_
32	by	by	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	presence	presence	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	excess	excess	JJ	JJ	_	38	amod	_	_
37	unlabeled	unlabeled	JJ	JJ	_	38	amod	_	_
38	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	34	punct	_	_
40	but	but	CC	CC	_	34	cc	_	_
41	not	not	RB	RB	_	44	neg	_	_
42	by	by	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	presence	presence	NN	NN	_	34	conj	_	_
45	of	of	IN	IN	_	47	case	_	_
46	unlabeled	unlabeled	JJ	JJ	_	47	amod	_	_
47	25(OH)D3	25(oh)d3	NN	NN	_	44	nmod	_	_
48	(	(	-LRB-	-LRB-	_	50	punct	_	_
49	receptor-positive	receptor-positive	JJ	JJ	_	50	amod	_	_
50	lymphocytes	lymphocyte	NNS	NNS	_	23	dep	_	_
51	:	:	:	:	_	50	punct	_	_
52	sarcoidosis	sarcoidosis	NN	NN	_	50	dep	_	_
53	,	,	,	,	_	52	punct	_	_
54	20	20	CD	CD	_	57	nummod	_	_
55	+/-	+/-	CC	CC	_	54	cc	_	_
56	12	12	CD	CD	_	54	conj	_	_
57	%	%	NN	NN	_	52	dep	_	_
58	;	;	:	:	_	52	punct	_	_
59	tuberculosis	tuberculosis	NN	NN	_	52	dep	_	_
60	,	,	,	,	_	59	punct	_	_
61	31	31	CD	CD	_	64	nummod	_	_
62	+/-	+/-	CC	CC	_	61	cc	_	_
63	17	17	CD	CD	_	61	conj	_	_
64	%	%	NN	NN	_	59	dep	_	_
65	)	)	-RRB-	-RRB-	_	50	punct	_	_
66	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	13	nsubj	_	_
6	from	from	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	granulomatous	granulomatous	JJ	JJ	_	10	amod	_	_
10	diseases	disease	NNS	NNS	_	7	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	express	express	VB	VB	_	0	root	_	_
14	detectable	detectable	JJ	JJ	_	16	amod	_	_
15	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	dobj	_	_
17	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	percentage	percentage	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	lavage	lavage	NN	NN	_	5	compound	_	_
5	T-lymphocytes	t-lymphocyte	NNS	NNS	_	2	nmod	_	_
6	expressing	express	VBG	VBG	_	5	acl	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	6	dobj	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	greater	greater	JJR	JJR	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	tuberculosis	tuberculosis	NN	NN	_	13	nmod	_	_
16	presenting	present	VBG	VBG	_	13	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	isolated	isolate	VBN	VBN	_	20	amod	_	_
19	hilar	hilar	JJ	JJ	_	20	amod	_	_
20	adenopathy	adenopathy	JJ	JJ	_	16	nmod	_	_
21	than	than	IN	IN	_	23	case	_	_
22	for	for	IN	IN	_	23	case	_	_
23	patients	patient	NNS	NNS	_	11	advcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	pulmonary	pulmonary	JJ	JJ	_	26	amod	_	_
26	infiltrates	infiltrate	NNS	NNS	_	23	nmod	_	_
27	and/or	and/or	CC	CC	_	26	cc	_	_
28	cavities	cavity	NNS	NNS	_	26	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	greater	greater	JJR	JJR	_	8	amod	_	_
8	extent	extent	NN	NN	_	4	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	CD8+	cd8+	JJ	JJ	_	11	amod	_	_
11	T-lymphocytes	t-lymphocyte	NNS	NNS	_	4	nmod	_	_
12	than	than	IN	IN	_	15	case	_	_
13	on	on	IN	IN	_	15	case	_	_
14	CD4+	cd4+	JJ	JJ	_	15	amod	_	_
15	T-lymphocytes	t-lymphocyte	NNS	NNS	_	4	advcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	sarcoidosis	sarcoidosis	NN	NN	_	4	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	whereas	whereas	IN	IN	_	4	dep	_	_
20	a	a	DT	DT	_	22	det	_	_
21	greater	greater	JJR	JJR	_	22	amod	_	_
22	proportion	proportion	NN	NN	_	34	nsubj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	CD4+	cd4+	JJ	JJ	_	22	nmod	_	_
25	than	than	IN	IN	_	27	case	_	_
26	of	of	IN	IN	_	27	case	_	_
27	CD8+	cd8+	JJ	JJ	_	22	acl	_	_
28	T-lymphocytes	t-lymphocyte	NNS	NNS	_	22	dep	_	_
29	from	from	IN	IN	_	30	case	_	_
30	patients	patient	NNS	NNS	_	22	nmod	_	_
31	with	with	IN	IN	_	32	case	_	_
32	tuberculosis	tuberculosis	NN	NN	_	30	nmod	_	_
33	were	be	VBD	VBD	_	34	cop	_	_
34	receptor-positive	receptor-positive	JJ	JJ	_	4	parataxis	_	_
35	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	conclusion	conclusion	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	17	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	on	on	IN	IN	_	15	case	_	_
15	T-lymphocytes	t-lymphocyte	NNS	NNS	_	13	nmod	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	play	play	VB	VB	_	5	ccomp	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	granulomatous	granulomatous	JJ	JJ	_	26	amod	_	_
26	reactions	reaction	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	3	punct	_	_
28	but	but	CC	CC	_	3	cc	_	_
29	because	because	IN	IN	_	33	mark	_	_
30	these	these	DT	DT	_	31	det	_	_
31	receptors	receptor	NNS	NNS	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	expressed	express	VBN	VBN	_	49	advcl	_	_
34	on	on	IN	IN	_	37	case	_	_
35	different	different	JJ	JJ	_	37	amod	_	_
36	lymphocyte	lymphocyte	NN	NN	_	37	compound	_	_
37	populations	population	NNS	NNS	_	33	nmod	_	_
38	,	,	,	,	_	49	punct	_	_
39	the	the	DT	DT	_	41	det	_	_
40	net	net	JJ	JJ	_	41	amod	_	_
41	effect	effect	NN	NN	_	49	nsubj	_	_
42	of	of	IN	IN	_	46	case	_	_
43	this	this	DT	DT	_	46	det	_	_
44	potent	potent	JJ	JJ	_	46	amod	_	_
45	immunoregulatory	immunoregulatory	JJ	JJ	_	46	amod	_	_
46	molecule	molecule	NN	NN	_	41	nmod	_	_
47	is	be	VBZ	VBZ	_	49	cop	_	_
48	likely	likely	RB	RB	_	49	advmod	_	_
49	different	different	JJ	JJ	_	3	conj	_	_
50	in	in	IN	IN	_	51	case	_	_
51	sarcoidosis	sarcoidosis	NN	NN	_	49	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	tuberculosis	tuberculosis	NN	NN	_	51	conj	_	_
54	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	belonging	belong	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	rel/NF-kappa	rel/nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	family	family	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	transdominant	transdominant	JJ	JJ	_	15	amod	_	_
14	negative	negative	JJ	JJ	_	15	amod	_	_
15	mutant	mutant	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	KBF1	kbf1	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	25	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	6	nmod	_	_
11	located	located	JJ	JJ	_	10	dep	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	promoter	promoter	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	mouse	mouse	NN	NN	_	22	compound	_	_
18	MHC	mhc	NN	NN	_	22	compound	_	_
19	class	class	NN	NN	_	22	compound	_	_
20	I	i	CD	CD	_	22	nummod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	H-2Kb	h-2kb	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	3	punct	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
26	from	from	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	p50	p50	NN	NN	_	31	compound	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	subunit	subunit	NN	NN	_	25	nmod	_	_
32	of	of	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	transcription	transcription	NN	NN	_	37	compound	_	_
35	factor	factor	NN	NN	_	37	compound	_	_
36	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
37	B	b	NN	NN	_	31	nmod	_	_
38	,	,	,	,	_	31	punct	_	_
39	which	which	WDT	WDT	_	40	nsubj	_	_
40	regulates	regulate	VBZ	VBZ	_	31	acl:relcl	_	_
41	a	a	DT	DT	_	42	det	_	_
42	series	series	NN	NN	_	40	dobj	_	_
43	of	of	IN	IN	_	44	case	_	_
44	genes	gene	NNS	NNS	_	42	nmod	_	_
45	involved	involve	VBN	VBN	_	44	acl	_	_
46	in	in	IN	IN	_	50	case	_	_
47	immune	immune	JJ	JJ	_	50	amod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	inflammatory	inflammatory	JJ	JJ	_	47	conj	_	_
50	responses	response	NNS	NNS	_	45	nmod	_	_
51	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	KBF1/p50	kbf1/p50	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	homodimer	homodimer	NN	NN	_	4	nmod	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	form	form	VB	VB	_	4	conj	_	_
12	heterodimers	heterodimer	NNS	NNS	_	11	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	products	product	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	members	member	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	same	same	JJ	JJ	_	22	amod	_	_
22	family	family	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	like	like	IN	IN	_	32	case	_	_
25	the	the	DT	DT	_	32	det	_	_
26	c-rel	c-rel	NN	NN	_	32	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	v-rel	v-rel	NN	NN	_	26	conj	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	proto	proto	NN	NN	_	32	compound	_	_
31	)	)	-RRB-	-RRB-	_	32	punct	_	_
32	oncogenes	oncogene	NNS	NNS	_	15	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dimerization	dimerization	NN	NN	_	3	compound	_	_
3	domain	domain	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	KBF1/p50	kbf1/p50	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	contained	contain	VBN	VBN	_	0	root	_	_
8	between	between	IN	IN	_	10	case	_	_
9	amino	amino	NN	NN	_	10	compound	_	_
10	acids	acid	NNS	NNS	_	7	nmod	_	_
11	201	201	CD	CD	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	367	367	CD	CD	_	11	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	mutant	mutant	NN	NN	_	25	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	KBF1/p50	kbf1/p50	NN	NN	_	7	compound	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	delta	delta	NN	NN	_	7	compound	_	_
7	SP	sp	NN	NN	_	2	nmod	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	2	punct	_	_
10	unable	unable	JJ	JJ	_	2	amod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	bind	bind	VB	VB	_	10	xcomp	_	_
13	to	to	TO	TO	_	14	case	_	_
14	DNA	dna	NN	NN	_	12	nmod	_	_
15	but	but	CC	CC	_	10	cc	_	_
16	able	able	JJ	JJ	_	10	conj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	form	form	VB	VB	_	16	xcomp	_	_
19	homo-	homo-	JJ	JJ	_	18	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	heterodimers	heterodimer	NNS	NNS	_	19	conj	_	_
22	,	,	,	,	_	2	punct	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	constructed	construct	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	reduces	reduce	VBZ	VBZ	_	0	root	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	abolishes	abolish	VBZ	VBZ	_	3	conj	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	3	advmod	_	_
8	the	the	DT	DT	_	11	det	_	_
9	DNA	dna	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	3	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	wild-type	wild-type	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	same	same	JJ	JJ	_	18	amod	_	_
18	family	family	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	KBF1/p50	kbf1/p50	NN	NN	_	14	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	c-	c-	NN	NN	_	20	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	v-rel	v-rel	NN	NN	_	22	conj	_	_
25	)	)	-RRB-	-RRB-	_	20	punct	_	_
26	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	mutant	mutant	JJ	JJ	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	functions	function	NNS	NNS	_	0	root	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vivo	vivo	FW	FW	_	4	advmod	_	_
7	as	as	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	trans-acting	trans-acting	JJ	JJ	_	12	amod	_	_
10	dominant	dominant	JJ	JJ	_	12	amod	_	_
11	negative	negative	JJ	JJ	_	12	amod	_	_
12	regulator	regulator	NN	NN	_	4	nmod	_	_
13	:	:	:	:	_	4	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	inducibility	inducibility	NN	NN	_	40	nsubjpass	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	HIV	hiv	NN	NN	_	22	compound	_	_
20	long	long	JJ	JJ	_	22	amod	_	_
21	terminal	terminal	JJ	JJ	_	22	amod	_	_
22	repeat	repeat	NN	NN	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	contains	contain	VBZ	VBZ	_	22	acl:relcl	_	_
26	two	two	CD	CD	_	31	nummod	_	_
27	potential	potential	JJ	JJ	_	31	amod	_	_
28	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	25	dobj	_	_
32	)	)	-RRB-	-RRB-	_	22	punct	_	_
33	by	by	IN	IN	_	35	case	_	_
34	phorbol	phorbol	NN	NN	_	35	compound	_	_
35	ester	ester	NN	NN	_	16	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	PMA	pma	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	inhibited	inhibit	VBN	VBN	_	4	parataxis	_	_
41	when	when	WRB	WRB	_	44	advmod	_	_
42	it	it	PRP	PRP	_	44	nsubjpass	_	_
43	is	be	VBZ	VBZ	_	44	auxpass	_	_
44	co-transfected	co-transfect	VBN	VBN	_	40	advcl	_	_
45	into	into	IN	IN	_	48	case	_	_
46	CD4+	cd4+	JJ	JJ	_	48	amod	_	_
47	T	t	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	44	nmod	_	_
49	with	with	IN	IN	_	53	case	_	_
50	the	the	DT	DT	_	53	det	_	_
51	delta	delta	NN	NN	_	53	compound	_	_
52	SP	sp	NN	NN	_	53	compound	_	_
53	mutant	mutant	NN	NN	_	44	nmod	_	_
54	.	.	.	.	_	40	punct	_	_

1	Similarly	similarly	RB	RB	_	20	advmod	_	_
2	the	the	DT	DT	_	10	det	_	_
3	basal	basal	JJ	JJ	_	10	amod	_	_
4	as	as	RB	RB	_	3	cc	_	_
5	well	well	RB	RB	_	4	mwe	_	_
6	as	as	IN	IN	_	4	mwe	_	_
7	TNF	tnf	NN	NN	_	3	conj	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	IL1-induced	il1-induced	JJ	JJ	_	7	conj	_	_
10	activity	activity	NN	NN	_	20	nsubjpass	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	MHC	mhc	NN	NN	_	17	compound	_	_
14	class	class	NN	NN	_	17	compound	_	_
15	I	i	CD	CD	_	17	nummod	_	_
16	H-2Kb	h-2kb	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	10	nmod	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	inhibited	inhibit	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	mutant	mutant	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	two	two	CD	CD	_	28	nummod	_	_
26	different	different	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	constitute	constitute	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	first	first	JJ	JJ	_	7	amod	_	_
6	formal	formal	JJ	JJ	_	7	amod	_	_
7	demonstration	demonstration	NN	NN	_	3	dobj	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	these	these	DT	DT	_	10	det	_	_
10	genes	gene	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	7	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	members	member	NNS	NNS	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	rel/NF-kappa	rel/nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	family	family	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
3	5-aminolevulinate	5-aminolevulinate	NN	NN	_	4	compound	_	_
4	synthase	synthase	NN	NN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	4	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	identification	identification	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	iron-responsive	iron-responsive	JJ	JJ	_	13	amod	_	_
13	element	element	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mRNA	mrna	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	5-Aminolevulinate	5-aminolevulinate	NN	NN	_	2	compound	_	_
2	synthase	synthase	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	ALAS	alas	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	catalyzes	catalyze	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	first	first	JJ	JJ	_	9	amod	_	_
9	step	step	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	heme	heme	NN	NN	_	14	compound	_	_
13	biosynthetic	biosynthetic	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	cDNA	cdna	NN	NN	_	2	compound	_	_
2	clones	clone	NNS	NNS	_	10	nsubjpass	_	_
3	for	for	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
7	ALAS	alas	NN	NN	_	8	compound	_	_
8	isozyme	isozyme	NN	NN	_	2	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	isolated	isolate	VBN	VBN	_	0	root	_	_
11	from	from	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	fetal	fetal	JJ	JJ	_	15	amod	_	_
14	liver	liver	NN	NN	_	15	compound	_	_
15	library	library	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	deduced	deduce	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
8	ALAS	alas	NN	NN	_	10	compound	_	_
9	precursor	precursor	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	11	nsubj	_	_
11	has	have	VBZ	VBZ	_	4	ccomp	_	_
12	a	a	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	weight	weight	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	64.6	64.6	CD	CD	_	17	nummod	_	_
17	kd	kd	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	similar	similar	JJ	JJ	_	11	conj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	size	size	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	31	case	_	_
25	the	the	DT	DT	_	31	det	_	_
26	previously	previously	RB	RB	_	27	advmod	_	_
27	isolated	isolate	VBN	VBN	_	31	amod	_	_
28	human	human	JJ	JJ	_	31	amod	_	_
29	housekeeping	housekeeping	JJ	JJ	_	31	amod	_	_
30	ALAS	alas	NN	NN	_	31	compound	_	_
31	precursor	precursor	NN	NN	_	21	nmod	_	_
32	of	of	IN	IN	_	36	case	_	_
33	molecular	molecular	JJ	JJ	_	36	amod	_	_
34	weight	weight	NN	NN	_	36	compound	_	_
35	70.6	70.6	CD	CD	_	36	nummod	_	_
36	kd	kd	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	mature	mature	JJ	JJ	_	4	amod	_	_
3	mitochondrial	mitochondrial	JJ	JJ	_	4	amod	_	_
4	forms	form	NNS	NNS	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	housekeeping	housekeeping	JJ	JJ	_	7	conj	_	_
10	ALAS	alas	NN	NN	_	11	compound	_	_
11	isozymes	isozyme	NNS	NNS	_	4	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	predicted	predict	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	have	have	VB	VB	_	13	xcomp	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	weights	weight	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	59.5	59.5	CD	CD	_	20	nummod	_	_
20	kd	kd	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	64.6	64.6	CD	CD	_	23	nummod	_	_
23	kd	kd	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	15	punct	_	_
25	respectively	respectively	RB	RB	_	15	advmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	isozymes	isozyme	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	little	little	JJ	JJ	_	8	amod	_	_
6	amino	amino	NN	NN	_	8	compound	_	_
7	acid	acid	NN	NN	_	8	compound	_	_
8	identity	identity	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
11	N-terminal	n-terminal	JJ	JJ	_	13	amod	_	_
12	signal	signal	NN	NN	_	13	compound	_	_
13	sequences	sequence	NNS	NNS	_	4	nmod	_	_
14	but	but	CC	CC	_	4	cc	_	_
15	have	have	VBP	VBP	_	4	conj	_	_
16	considerable	considerable	JJ	JJ	_	18	amod	_	_
17	sequence	sequence	NN	NN	_	18	compound	_	_
18	identity	identity	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	C-terminal	c-terminal	JJ	JJ	_	22	amod	_	_
22	two-thirds	two-thirds	CD	CD	_	15	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	analysis	analysis	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	immediate	immediate	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
11	ALAS	alas	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	several	several	JJ	JJ	_	18	amod	_	_
15	putative	putative	JJ	JJ	_	18	amod	_	_
16	erythroid-specific	erythroid-specific	JJ	JJ	_	18	amod	_	_
17	cis-acting	cis-acting	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	13	dobj	_	_
19	including	include	VBG	VBG	_	22	case	_	_
20	both	both	PDT	PDT	_	22	cc:preconj	_	_
21	a	a	DT	DT	_	22	det	_	_
22	GATA-1	gata-1	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	an	a	DT	DT	_	25	det	_	_
25	NF-E2	nf-e2	NN	NN	_	22	conj	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	22	dep	_	_
28	.	.	.	.	_	13	punct	_	_

1	An	a	DT	DT	_	7	det	_	_
2	iron-responsive	iron-responsive	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IRE	ire	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	motif	motif	NN	NN	_	10	nsubjpass	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	5'-untranslated	5'-untranslated	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
19	ALAS	alas	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	but	but	CC	CC	_	10	cc	_	_
23	is	be	VBZ	VBZ	_	25	cop	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	present	present	JJ	JJ	_	10	conj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	housekeeping	housekeeping	JJ	JJ	_	30	amod	_	_
29	ALAS	alas	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	retardation	retardation	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	established	establish	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	this	this	DT	DT	_	8	det	_	_
7	IRE	ire	NN	NN	_	8	compound	_	_
8	motif	motif	NN	NN	_	9	nsubj	_	_
9	formed	form	VBD	VBD	_	4	ccomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	protein-RNA	protein-rna	JJ	JJ	_	12	compound	_	_
12	complex	complex	NN	NN	_	9	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	cytosolic	cytosolic	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	9	nmod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	K562	k562	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	this	this	DT	DT	_	22	det	_	_
22	binding	binding	NN	NN	_	25	nsubjpass	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	strongly	strongly	RB	RB	_	25	advmod	_	_
25	competed	compete	VBN	VBN	_	9	conj	_	_
26	with	with	IN	IN	_	28	case	_	_
27	IRE	ire	NN	NN	_	28	compound	_	_
28	transcripts	transcript	NNS	NNS	_	25	nmod	_	_
29	from	from	IN	IN	_	34	case	_	_
30	ferritin	ferritin	NN	NN	_	33	compound	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	transferrin	transferrin	NN	NN	_	30	conj	_	_
33	receptor	receptor	NN	NN	_	34	compound	_	_
34	mRNAs	mrna	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	transcript	transcript	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	ALAS	alas	NN	NN	_	6	compound	_	_
6	IRE	ire	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	mutated	mutate	VBN	VBN	_	2	acl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	conserved	conserve	VBN	VBN	_	12	amod	_	_
12	loop	loop	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	IRE	ire	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	did	do	VBD	VBD	_	20	aux	_	_
18	not	not	RB	RB	_	20	neg	_	_
19	readily	readily	RB	RB	_	20	advmod	_	_
20	form	form	VB	VB	_	0	root	_	_
21	this	this	DT	DT	_	23	det	_	_
22	protein-RNA	protein-rna	JJ	JJ	_	23	compound	_	_
23	complex	complex	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IRE	ire	NN	NN	_	7	compound	_	_
7	motif	motif	NN	NN	_	13	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	ALAS	alas	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	functional	functional	JJ	JJ	_	3	ccomp	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	imply	imply	VBP	VBP	_	3	conj	_	_
16	that	that	IN	IN	_	22	mark	_	_
17	translation	translation	NN	NN	_	22	nsubjpass	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	controlled	control	VBN	VBN	_	15	ccomp	_	_
23	by	by	IN	IN	_	26	case	_	_
24	cellular	cellular	JJ	JJ	_	26	amod	_	_
25	iron	iron	NN	NN	_	26	compound	_	_
26	availability	availability	NN	NN	_	22	nmod	_	_
27	during	during	IN	IN	_	28	case	_	_
28	erythropoiesis	erythropoiesis	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	7	amod	_	_
2	tumor	tumor	NN	NN	_	7	compound	_	_
3	necrosis	necrosis	NN	NN	_	7	compound	_	_
4	factor	factor	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	phorbol	phorbol	NN	NN	_	10	dep	_	_
10	ester	ester	NN	NN	_	12	amod	_	_
11	stimulated	stimulate	VBD	VBD	_	10	dep	_	_
12	T	t	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	minimal	minimal	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	37	nsubj	_	_
4	of	of	IN	IN	_	15	case	_	_
5	the	the	DT	DT	_	15	det	_	_
6	human	human	JJ	JJ	_	15	amod	_	_
7	tumor	tumor	NN	NN	_	15	compound	_	_
8	necrosis	necrosis	NN	NN	_	15	compound	_	_
9	factor	factor	NN	NN	_	15	compound	_	_
10	alpha	alpha	NN	NN	_	15	compound	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
13	)	)	-RRB-	-RRB-	_	15	punct	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	3	nmod	_	_
16	necessary	necessary	JJ	JJ	_	15	amod	_	_
17	for	for	IN	IN	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	induction	induction	NN	NN	_	16	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	phorbol	phorbol	NN	NN	_	23	compound	_	_
23	esters	ester	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PMA	pma	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	T	t	NN	NN	_	20	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	B	b	NN	NN	_	34	compound	_	_
32	lymphocyte	lymphocyte	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	29	conj	_	_
35	has	have	VBZ	VBZ	_	37	aux	_	_
36	been	be	VBN	VBN	_	37	aux	_	_
37	localized	localized	JJ	JJ	_	0	root	_	_
38	between	between	IN	IN	_	39	case	_	_
39	-52	-52	CD	CD	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	+89	+89	CD	CD	_	39	conj	_	_
42	nucleotides	nucleotide	NNS	NNS	_	39	dep	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	nt	nt	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	relative	relative	JJ	JJ	_	37	advmod	_	_
47	to	to	TO	TO	_	53	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	gene	gene	NN	NN	_	53	nmod:poss	_	_
50	's	's	POS	POS	_	49	case	_	_
51	transcriptional	transcriptional	JJ	JJ	_	53	amod	_	_
52	start	start	NN	NN	_	53	compound	_	_
53	site	site	NN	NN	_	46	nmod	_	_
54	.	.	.	.	_	37	punct	_	_

1	Comparison	comparison	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	those	those	DT	DT	_	1	nmod	_	_
7	required	require	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	mediate	mediate	VB	VB	_	7	xcomp	_	_
10	virus	virus	NN	NN	_	16	compound	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	lipopolysaccharide	lipopolysaccharide	NN	NN	_	10	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LPS	lps	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	induction	induction	NN	NN	_	9	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	gene	gene	NN	NN	_	16	nmod	_	_
20	reveal	reveal	VB	VB	_	0	root	_	_
21	significant	significant	JJ	JJ	_	22	amod	_	_
22	differences	difference	NNS	NNS	_	20	dobj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	thus	thus	RB	RB	_	20	advmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	the	the	DT	DT	_	29	det	_	_
28	sequence	sequence	NN	NN	_	29	compound	_	_
29	requirements	requirement	NNS	NNS	_	34	nsubj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	PMA	pma	NN	NN	_	32	compound	_	_
32	induction	induction	NN	NN	_	29	nmod	_	_
33	are	be	VBP	VBP	_	34	cop	_	_
34	distinct	distinct	JJ	JJ	_	20	ccomp	_	_
35	from	from	IN	IN	_	36	case	_	_
36	those	those	DT	DT	_	34	nmod	_	_
37	that	that	WDT	WDT	_	38	nsubj	_	_
38	mediate	mediate	VBP	VBP	_	36	acl:relcl	_	_
39	induction	induction	NN	NN	_	38	dobj	_	_
40	by	by	IN	IN	_	41	case	_	_
41	virus	virus	NN	NN	_	39	nmod	_	_
42	or	or	CC	CC	_	41	cc	_	_
43	LPS	lps	NN	NN	_	41	conj	_	_
44	.	.	.	.	_	20	punct	_	_

1	Although	although	IN	IN	_	20	mark	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	sites	site	NNS	NNS	_	20	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	kappa	kappa	NN	NN	_	3	dep	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	,	,	,	,	_	9	punct	_	_
12	kappa	kappa	NN	NN	_	9	conj	_	_
13	2	2	CD	CD	_	12	nummod	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	kappa	kappa	NN	NN	_	9	conj	_	_
17	3	3	CD	CD	_	16	nummod	_	_
18	)	)	-RRB-	-RRB-	_	9	punct	_	_
19	specifically	specifically	RB	RB	_	20	advmod	_	_
20	bind	bind	VBP	VBP	_	38	advcl	_	_
21	the	the	DT	DT	_	25	det	_	_
22	transcription	transcription	NN	NN	_	25	compound	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	20	dobj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	extracts	extract	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	38	punct	_	_
31	TNF-alpha	tnf-alpha	NN	NN	_	33	compound	_	_
32	mRNA	mrna	NN	NN	_	33	compound	_	_
33	induction	induction	NN	NN	_	38	nsubj	_	_
34	by	by	IN	IN	_	35	case	_	_
35	PMA	pma	NN	NN	_	33	nmod	_	_
36	does	do	VBZ	VBZ	_	38	aux	_	_
37	not	not	RB	RB	_	38	neg	_	_
38	correlate	correlate	VB	VB	_	0	root	_	_
39	with	with	IN	IN	_	43	case	_	_
40	NF-kappa	nf-kappa	NN	NN	_	43	compound	_	_
41	B	b	NN	NN	_	43	compound	_	_
42	binding	binding	NN	NN	_	43	compound	_	_
43	activities	activity	NNS	NNS	_	38	nmod	_	_
44	displayed	display	VBN	VBN	_	43	acl	_	_
45	by	by	IN	IN	_	47	case	_	_
46	different	different	JJ	JJ	_	47	amod	_	_
47	T	t	NN	NN	_	44	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	B	b	NN	NN	_	51	compound	_	_
50	cell	cell	NN	NN	_	51	compound	_	_
51	lines	line	NNS	NNS	_	47	conj	_	_
52	.	.	.	.	_	38	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	kappa	kappa	NN	NN	_	11	nsubjpass	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	-	-	:	:	_	3	punct	_	_
6	kappa	kappa	NN	NN	_	3	dep	_	_
7	3	3	CD	CD	_	6	nummod	_	_
8	can	can	MD	MD	_	11	aux	_	_
9	each	each	DT	DT	_	11	dep	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	deleted	delete	VBN	VBN	_	0	root	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	little	little	JJ	JJ	_	18	amod	_	_
18	effect	effect	NN	NN	_	11	nmod	_	_
19	on	on	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	gene	gene	NN	NN	_	23	nmod:poss	_	_
22	's	's	POS	POS	_	21	case	_	_
23	inducibility	inducibility	NN	NN	_	18	nmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	PMA	pma	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Therefore	therefore	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	TNF-alpha	tnf-alpha	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	20	nsubjpass	_	_
6	by	by	IN	IN	_	7	case	_	_
7	PMA	pma	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	20	punct	_	_
9	like	like	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	induction	induction	NN	NN	_	20	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	virus	virus	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	LPS	lps	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	20	punct	_	_
17	is	be	VBZ	VBZ	_	20	auxpass	_	_
18	not	not	RB	RB	_	20	neg	_	_
19	primarily	primarily	RB	RB	_	20	advmod	_	_
20	mediated	mediate	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	rather	rather	RB	RB	_	20	cc	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	mediated	mediate	VBN	VBN	_	20	conj	_	_
29	through	through	IN	IN	_	31	case	_	_
30	other	other	JJ	JJ	_	31	amod	_	_
31	sequences	sequence	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	31	conj	_	_
35	.	.	.	.	_	20	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	multimers	multimer	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	kappa	kappa	NN	NN	_	3	nmod	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	-	-	:	:	_	5	punct	_	_
8	kappa	kappa	NN	NN	_	5	dep	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	confer	confer	VB	VB	_	0	root	_	_
12	PMA	pma	NN	NN	_	13	compound	_	_
13	inducibility	inducibility	NN	NN	_	11	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	11	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	B	b	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	Raji	raji	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	20	punct	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	20	cc	_	_
27	a	a	DT	DT	_	28	det	_	_
28	T	t	NN	NN	_	20	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HUT78	hut78	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	line	line	NN	NN	_	20	dep	_	_
34	.	.	.	.	_	11	punct	_	_

1	However	however	WRB	WRB	_	5	advmod	_	_
2	they	they	PRP	PRP	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	functional	functional	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	truncated	truncate	VBN	VBN	_	10	amod	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	indicating	indicate	VBG	VBG	_	5	xcomp	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	context	context	NN	NN	_	20	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	type	type	NN	NN	_	19	compound	_	_
19	specificity	specificity	NN	NN	_	15	conj	_	_
20	influence	influence	VBP	VBP	_	12	ccomp	_	_
21	the	the	DT	DT	_	24	det	_	_
22	PMA	pma	NN	NN	_	24	compound	_	_
23	inducible	inducible	JJ	JJ	_	24	amod	_	_
24	function	function	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	these	these	DT	DT	_	30	det	_	_
27	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	sites	site	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	Towards	towards	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	molecular	molecular	JJ	JJ	_	4	amod	_	_
4	understanding	understanding	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Lymphoid	lymphoid	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	one	one	CD	CD	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	best	best	RBS	RBS	_	8	advmod	_	_
8	studied	study	VBN	VBN	_	9	amod	_	_
9	examples	example	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	mammalian	mammalian	JJ	JJ	_	12	amod	_	_
12	development	development	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	7	advmod	_	_
2	Hans	Hans	NNP	NNP	_	3	compound	_	_
3	Clevers	Clevers	NNP	NNP	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Michael	Michael	NNP	NNP	_	6	compound	_	_
6	Owen	Owen	NNP	NNP	_	3	conj	_	_
7	describe	describe	VBP	VBP	_	0	root	_	_
8	how	how	WRB	WRB	_	19	advmod	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cloning	cloning	NN	NN	_	19	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	encode	encode	VBP	VBP	_	13	acl:relcl	_	_
16	T-cell-specific	t-cell-specific	JJ	JJ	_	15	dep	_	_
17	membrane	membrane	NN	NN	_	15	dep	_	_
18	proteins	protein	NNS	NNS	_	15	dep	_	_
19	allows	allow	VBZ	VBZ	_	7	ccomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	identification	identification	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	control	control	VBP	VBP	_	24	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	these	these	DT	DT	_	32	det	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	genes	gene	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	key	key	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	development	development	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	mature	mature	JJ	JJ	_	15	amod	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	phenotype	phenotype	NN	NN	_	10	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	functioning	function	VBG	VBG	_	4	advcl	_	_
18	as	as	IN	IN	_	21	case	_	_
19	'	'	``	``	_	21	punct	_	_
20	master	master	JJ	JJ	_	21	amod	_	_
21	regulators	regulator	NNS	NNS	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	differentiation	differentiation	NN	NN	_	21	nmod	_	_
25	'	'	''	''	_	21	punct	_	_
26	.	.	.	.	_	4	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	jun	jun	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	fos	fos	NN	NN	_	3	conj	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	macrophage	macrophage	NN	NN	_	14	nmod:npmod	_	_
14	colony-stimulating	colony-stimulating	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	macrophage	macrophage	NN	NN	_	3	nmod:npmod	_	_
3	colony-stimulating	colony-stimulating	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	M-CSF	m-csf	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	required	require	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	growth	growth	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	differentiation	differentiation	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
17	phagocytes	phagocyte	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	events	event	NNS	NNS	_	10	nsubj	_	_
6	responsible	responsible	JJ	JJ	_	5	amod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	effects	effect	NNS	NNS	_	6	nmod	_	_
10	remain	remain	VBP	VBP	_	0	root	_	_
11	unclear	unclear	JJ	JJ	_	10	xcomp	_	_
12	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	M-CSF	m-csf	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	potential	potential	JJ	JJ	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	7	nmod	_	_
14	involving	involve	VBG	VBG	_	13	acl	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	jun	jun	NN	NN	_	23	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	fos	fos	NN	NN	_	18	conj	_	_
21	early	early	JJ	JJ	_	23	amod	_	_
22	response	response	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Low	low	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	detectable	detectable	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	resting	rest	VBG	VBG	_	13	amod	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Treatment	treatment	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	10	case	_	_
6	10(3)	10(3)	CD	CD	_	10	nummod	_	_
7	units/ml	units/ml	NNS	NNS	_	10	compound	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	recombinant	recombinant	JJ	JJ	_	10	amod	_	_
10	M-CSF	m-csf	NN	NN	_	1	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	17	case	_	_
14	rapid	rapid	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	transient	transient	JJ	JJ	_	14	conj	_	_
17	increases	increase	NNS	NNS	_	12	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	c-jun	c-jun	NN	NN	_	21	compound	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	mRNA	mrna	NN	NN	_	7	compound	_	_
6	stability	stability	NN	NN	_	7	compound	_	_
7	studies	study	NNS	NNS	_	3	conj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	M-CSF	m-csf	NN	NN	_	11	nsubj	_	_
11	regulates	regulate	VBZ	VBZ	_	8	ccomp	_	_
12	c-jun	c-jun	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	by	by	IN	IN	_	17	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	an	a	DT	DT	_	17	det	_	_
17	increase	increase	NN	NN	_	11	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	rate	rate	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	a	a	DT	DT	_	23	det	_	_
23	prolongation	prolongation	NN	NN	_	17	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	half-life	half-life	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	c-jun	c-jun	NN	NN	_	29	compound	_	_
29	transcripts	transcript	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	M-CSF	m-csf	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	rapid	rapid	JJ	JJ	_	9	amod	_	_
9	induction	induction	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	jun-B	jun-b	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	although	although	IN	IN	_	21	mark	_	_
16	expression	expression	NN	NN	_	21	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	gene	gene	NN	NN	_	16	nmod	_	_
20	was	be	VBD	VBD	_	21	aux	_	_
21	prolonged	prolonged	JJ	JJ	_	5	advcl	_	_
22	compared	compare	VBN	VBN	_	21	dep	_	_
23	to	to	TO	TO	_	24	case	_	_
24	that	that	DT	DT	_	22	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	c-jun	c-jun	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	M-CSF	m-csf	NN	NN	_	6	nsubj	_	_
6	increases	increase	VBZ	VBZ	_	3	ccomp	_	_
7	c-fos	c-fos	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	through	through	IN	IN	_	14	case	_	_
14	control	control	NN	NN	_	6	nmod	_	_
15	at	at	IN	IN	_	21	case	_	_
16	both	both	CC	CC	_	21	dep	_	_
17	the	the	DT	DT	_	21	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	posttranscriptional	posttranscriptional	JJ	JJ	_	18	conj	_	_
21	levels	level	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Maximal	maximal	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	c-fos	c-fos	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	followed	follow	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	that	that	DT	DT	_	8	nmod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	fos-B	fos-b	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	M-CSF-induced	m-csf-induced	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	fos-related	fos-related	JJ	JJ	_	8	amod	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	fra-1	fra-1	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	4	punct	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	delayed	delay	VBN	VBN	_	0	root	_	_
14	compared	compare	VBN	VBN	_	13	dep	_	_
15	to	to	TO	TO	_	16	case	_	_
16	that	that	DT	DT	_	14	nmod	_	_
17	for	for	IN	IN	_	19	case	_	_
18	both	both	DT	DT	_	19	cc:preconj	_	_
19	c-fos	c-fos	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	fos-B	fos-b	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	13	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	M-CSF	m-csf	NN	NN	_	9	compound	_	_
9	treatment	treatment	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	6	ccomp	_	_
12	with	with	IN	IN	_	14	case	_	_
13	differential	differential	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	multiple	multiple	JJ	JJ	_	17	amod	_	_
17	members	member	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	jun/fos	jun/fos	NN	NN	_	21	compound	_	_
21	family	family	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	that	that	IN	IN	_	29	mark	_	_
24	expression	expression	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	could	could	MD	MD	_	29	aux	_	_
29	contribute	contribute	VB	VB	_	11	conj	_	_
30	to	to	TO	TO	_	33	case	_	_
31	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
32	signaling	signaling	NN	NN	_	33	compound	_	_
33	mechanisms	mechanism	NNS	NNS	_	29	nmod	_	_
34	that	that	WDT	WDT	_	35	nsubj	_	_
35	regulate	regulate	VBP	VBP	_	33	acl:relcl	_	_
36	a	a	DT	DT	_	38	det	_	_
37	specific	specific	JJ	JJ	_	38	amod	_	_
38	program	program	NN	NN	_	35	dobj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	monocyte	monocyte	NN	NN	_	41	compound	_	_
41	differentiation	differentiation	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	6	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	homeobox	homeobox	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	resembles	resemble	VBZ	VBZ	_	6	acl:relcl	_	_
9	a	a	DT	DT	_	13	det	_	_
10	diverged	diverged	JJ	JJ	_	13	amod	_	_
11	Drosophila	drosophila	NN	NN	_	13	compound	_	_
12	homeobox	homeobox	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	xcomp	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	expressed	express	VBN	VBN	_	8	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	new	new	JJ	JJ	_	4	amod	_	_
3	homeobox	homeobox	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	10	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	HB24	hb24	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	isolated	isolate	VBN	VBN	_	0	root	_	_
11	from	from	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	B-lymphocyte	b-lymphocyte	NN	NN	_	16	compound	_	_
15	cDNA	cdna	NN	NN	_	16	compound	_	_
16	library	library	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Northern	northern	JJ	JJ	_	3	amod	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	polyadenylated	polyadenylated	JJ	JJ	_	6	amod	_	_
6	RNA	rna	NN	NN	_	3	nmod	_	_
7	purified	purify	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	12	case	_	_
9	activated	activate	VBN	VBN	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	single	single	JJ	JJ	_	17	amod	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	transcript	transcript	NN	NN	_	13	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	approximately	approximately	RB	RB	_	20	advmod	_	_
20	2.3	2.3	CD	CD	_	21	nummod	_	_
21	kb	kb	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	sequenced	sequence	VBN	VBN	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	provided	provide	VBN	VBN	_	5	conj	_	_
8	2,250	2,250	CD	CD	_	9	nummod	_	_
9	nucleotides	nucleotide	NNS	NNS	_	7	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	nt	nt	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	of	of	IN	IN	_	16	case	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	sequence	sequence	NN	NN	_	16	compound	_	_
16	information	information	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	9	det	_	_
4	single	single	JJ	JJ	_	9	amod	_	_
5	methionine	methionine	NN	NN	_	6	nmod:npmod	_	_
6	codon-initiated	codon-initiated	JJ	JJ	_	9	amod	_	_
7	open	open	JJ	JJ	_	9	amod	_	_
8	reading	reading	NN	NN	_	9	compound	_	_
9	frame	frame	NN	NN	_	2	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	1,458	1,458	CD	CD	_	12	nummod	_	_
12	nt	nt	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	frame	frame	NN	NN	_	2	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	homeobox	homeobox	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	a	a	DT	DT	_	21	det	_	_
20	CAX	cax	NN	NN	_	21	compound	_	_
21	repeat	repeat	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	2	punct	_	_
23	and	and	CC	CC	_	2	cc	_	_
24	the	the	DT	DT	_	27	det	_	_
25	open	open	JJ	JJ	_	27	amod	_	_
26	reading	reading	NN	NN	_	27	compound	_	_
27	frame	frame	NN	NN	_	29	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	predicted	predict	VBN	VBN	_	2	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	encode	encode	VB	VB	_	29	xcomp	_	_
32	a	a	DT	DT	_	33	det	_	_
33	protein	protein	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	51,659	51,659	CD	CD	_	36	nummod	_	_
36	daltons	dalton	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	7	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	homeodomain	homeodomain	NN	NN	_	7	nsubjpass	_	_
4	from	from	IN	IN	_	5	case	_	_
5	HB24	hb24	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	compared	compare	VBN	VBN	_	16	advcl	_	_
8	to	to	TO	TO	_	13	case	_	_
9	known	known	JJ	JJ	_	13	amod	_	_
10	mammalian	mammalian	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Drosophila	drosophila	NN	NN	_	10	conj	_	_
13	homeodomains	homeodomain	NNS	NNS	_	7	nmod	_	_
14	it	it	PRP	PRP	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	found	find	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	21	mark	_	_
18	be	be	VB	VB	_	21	auxpass	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	moderately	moderately	RB	RB	_	21	advmod	_	_
21	conserved	conserve	VBN	VBN	_	16	xcomp	_	_
22	,	,	,	,	_	16	punct	_	_
23	but	but	CC	CC	_	16	cc	_	_
24	when	when	WRB	WRB	_	27	advmod	_	_
25	it	it	PRP	PRP	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	compared	compare	VBN	VBN	_	39	advcl	_	_
28	to	to	TO	TO	_	33	case	_	_
29	a	a	DT	DT	_	33	det	_	_
30	highly	highly	RB	RB	_	31	advmod	_	_
31	diverged	diverged	JJ	JJ	_	33	amod	_	_
32	Drosophila	drosophila	FW	FW	_	33	compound	_	_
33	homeodomain	homeodomain	NN	NN	_	27	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	H2.0	h2.0	NN	NN	_	33	appos	_	_
36	,	,	,	,	_	33	punct	_	_
37	it	it	PRP	PRP	_	39	nsubjpass	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	found	find	VBN	VBN	_	16	conj	_	_
40	to	to	TO	TO	_	44	mark	_	_
41	be	be	VB	VB	_	44	cop	_	_
42	80	80	CD	CD	_	43	nummod	_	_
43	%	%	NN	NN	_	44	nmod:npmod	_	_
44	identical	identical	JJ	JJ	_	39	xcomp	_	_
45	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HB24	hb24	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	absent	absent	JJ	JJ	_	0	root	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	present	present	JJ	JJ	_	5	conj	_	_
8	at	at	IN	IN	_	10	case	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	normal	normal	JJ	JJ	_	16	amod	_	_
13	B	b	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	13	conj	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
17	;	;	:	:	_	5	punct	_	_
18	however	however	RB	RB	_	28	advmod	_	_
19	,	,	,	,	_	28	punct	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	appropriate	appropriate	JJ	JJ	_	24	amod	_	_
23	activation	activation	NN	NN	_	24	compound	_	_
24	signal	signal	NN	NN	_	28	nmod	_	_
25	HB24	hb24	NN	NN	_	26	compound	_	_
26	mRNA	mrna	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	induced	induce	VBN	VBN	_	5	parataxis	_	_
29	within	within	IN	IN	_	31	case	_	_
30	several	several	JJ	JJ	_	31	amod	_	_
31	hours	hour	NNS	NNS	_	28	nmod	_	_
32	even	even	RB	RB	_	37	advmod	_	_
33	in	in	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	dep	_	_
35	presence	presence	NN	NN	_	37	dep	_	_
36	of	of	IN	IN	_	37	case	_	_
37	cycloheximide	cycloheximide	NN	NN	_	28	nmod	_	_
38	.	.	.	.	_	28	punct	_	_

1	Characterization	characterization	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HB24	hb24	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	lymphoid	lymphoid	JJ	JJ	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	select	select	JJ	JJ	_	10	amod	_	_
9	developing	develop	VBG	VBG	_	10	amod	_	_
10	tissues	tissue	NNS	NNS	_	6	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	performed	perform	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	situ	situ	FW	FW	_	14	dep	_	_
16	hybridization	hybridization	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Positive	positive	JJ	JJ	_	2	amod	_	_
2	hybridization	hybridization	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	thymus	thymus	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	tonsil	tonsil	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	bone	bone	NN	NN	_	11	compound	_	_
11	marrow	marrow	NN	NN	_	6	appos	_	_
12	,	,	,	,	_	6	punct	_	_
13	developing	develop	VBG	VBG	_	14	amod	_	_
14	vessels	vessel	NNS	NNS	_	6	appos	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	in	in	IN	IN	_	19	case	_	_
18	fetal	fetal	JJ	JJ	_	19	amod	_	_
19	brain	brain	NN	NN	_	6	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	HB24	hb24	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	likely	likely	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	have	have	VB	VB	_	3	xcomp	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
11	as	as	RB	RB	_	10	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	in	in	IN	IN	_	17	case	_	_
15	certain	certain	JJ	JJ	_	17	amod	_	_
16	developing	develop	VBG	VBG	_	17	amod	_	_
17	tissues	tissue	NNS	NNS	_	10	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Severe	severe	JJ	JJ	_	3	amod	_	_
2	5-fluorouracil	5-fluorouracil	NN	NN	_	3	compound	_	_
3	toxicity	toxicity	NN	NN	_	0	root	_	_
4	secondary	secondary	JJ	JJ	_	3	amod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	dihydropyrimidine	dihydropyrimidine	NN	NN	_	8	compound	_	_
7	dehydrogenase	dehydrogenase	NN	NN	_	8	compound	_	_
8	deficiency	deficiency	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	potentially	potentially	RB	RB	_	4	advmod	_	_
3	more	more	RBR	RBR	_	4	advmod	_	_
4	common	common	JJ	JJ	_	6	amod	_	_
5	pharmacogenetic	pharmacogenetic	JJ	JJ	_	6	amod	_	_
6	syndrome	syndrome	NN	NN	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	describes	describe	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	inheritance	inheritance	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	defect	defect	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	pyrimidine	pyrimidine	NN	NN	_	11	compound	_	_
11	catabolism	catabolism	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	association	association	NN	NN	_	5	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	drug-induced	drug-induced	JJ	JJ	_	17	amod	_	_
17	toxicity	toxicity	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	patient	patient	NN	NN	_	5	nmod	_	_
21	receiving	receive	VBG	VBG	_	20	acl	_	_
22	5-fluorouracil	5-fluorouracil	NN	NN	_	21	dobj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	FUra	fura	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	as	as	IN	IN	_	28	case	_	_
27	adjuvant	adjuvant	JJ	JJ	_	28	amod	_	_
28	chemotherapy	chemotherapy	NN	NN	_	21	nmod	_	_
29	for	for	IN	IN	_	31	case	_	_
30	breast	breast	NN	NN	_	31	compound	_	_
31	carcinoma	carcinoma	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	study	study	NN	NN	_	3	compound	_	_
3	population	population	NN	NN	_	4	nsubj	_	_
4	included	include	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	affected	affect	VBN	VBN	_	7	amod	_	_
7	patient	patient	NN	NN	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	proband	proband	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	nine	nine	CD	CD	_	7	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	her	she	PRP$	PRP$	_	16	nmod:poss	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	relatives	relative	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	seven	seven	CD	CD	_	21	nummod	_	_
20	healthy	healthy	JJ	JJ	_	21	amod	_	_
21	volunteers	volunteer	NNS	NNS	_	7	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	27	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	dihydropyrimidine	dihydropyrimidine	NN	NN	_	5	compound	_	_
5	dehydrogenase	dehydrogenase	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DPD	dpd	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	initial	initial	JJ	JJ	_	12	amod	_	_
12	enzyme	enzyme	NN	NN	_	5	appos	_	_
13	of	of	IN	IN	_	19	case	_	_
14	pyrimidine	pyrimidine	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	14	punct	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	FUra	fura	NN	NN	_	14	conj	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	catabolism	catabolism	NN	NN	_	12	nmod	_	_
20	,	,	,	,	_	5	punct	_	_
21	in	in	IN	IN	_	25	case	_	_
22	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
23	blood	blood	NN	NN	_	25	compound	_	_
24	mononuclear	mononuclear	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	5	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	measured	measure	VBN	VBN	_	0	root	_	_
28	in	in	IN	IN	_	30	case	_	_
29	each	each	DT	DT	_	30	det	_	_
30	subject	subject	NN	NN	_	27	nmod	_	_
31	by	by	IN	IN	_	35	case	_	_
32	a	a	DT	DT	_	35	det	_	_
33	specific	specific	JJ	JJ	_	35	amod	_	_
34	radiometric	radiometric	JJ	JJ	_	35	amod	_	_
35	assay	assay	NN	NN	_	27	nmod	_	_
36	using	use	VBG	VBG	_	35	acl	_	_
37	FUra	fura	NN	NN	_	36	dobj	_	_
38	as	as	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	substrate	substrate	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proband	proband	NN	NN	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	no	no	DT	DT	_	7	neg	_	_
5	detectable	detectable	JJ	JJ	_	7	amod	_	_
6	DPD	dpd	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	10	advmod	_	_
2	enzyme	enzyme	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	10	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	proband	proband	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	relatives	relative	NNS	NNS	_	6	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	compared	compare	VBN	VBN	_	23	advcl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	controls	control	NNS	NNS	_	12	nmod	_	_
15	,	,	,	,	_	23	punct	_	_
16	an	a	DT	DT	_	19	det	_	_
17	autosomal	autosomal	JJ	JJ	_	19	amod	_	_
18	recessive	recessive	JJ	JJ	_	19	amod	_	_
19	pattern	pattern	NN	NN	_	23	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	inheritance	inheritance	NN	NN	_	19	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	third	third	JJ	JJ	_	5	amod	_	_
5	patient	patient	NN	NN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	severe	severe	JJ	JJ	_	9	amod	_	_
8	FUra	fura	NN	NN	_	9	compound	_	_
9	toxicity	toxicity	NN	NN	_	5	nmod	_	_
10	secondary	secondary	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	an	a	DT	DT	_	13	det	_	_
13	alteration	alteration	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	pyrimidine	pyrimidine	NN	NN	_	16	compound	_	_
16	catabolism	catabolism	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	second	second	NN	NN	_	5	conj	_	_
20	from	from	IN	IN	_	23	case	_	_
21	our	we	PRP$	PRP$	_	23	nmod:poss	_	_
22	clinic	clinic	NN	NN	_	23	compound	_	_
23	population	population	NN	NN	_	19	nmod	_	_
24	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
25	that	that	IN	IN	_	34	mark	_	_
26	the	the	DT	DT	_	27	det	_	_
27	frequency	frequency	NN	NN	_	34	nsubj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	this	this	DT	DT	_	31	det	_	_
30	genetic	genetic	JJ	JJ	_	31	amod	_	_
31	defect	defect	NN	NN	_	27	nmod	_	_
32	may	may	MD	MD	_	34	aux	_	_
33	be	be	VB	VB	_	34	cop	_	_
34	greater	greater	JJR	JJR	_	24	ccomp	_	_
35	than	than	IN	IN	_	37	mark	_	_
36	previously	previously	RB	RB	_	37	advmod	_	_
37	thought	think	VBN	VBN	_	34	ccomp	_	_
38	.	.	.	.	_	5	punct	_	_

1	Monitoring	monitor	VBG	VBG	_	6	csubj	_	_
2	DPD	dpd	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	1	dobj	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	important	important	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	management	management	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	9	nmod	_	_
12	experiencing	experience	VBG	VBG	_	11	acl	_	_
13	severe	severe	JJ	JJ	_	14	amod	_	_
14	toxicity	toxicity	NN	NN	_	12	dobj	_	_
15	secondary	secondary	JJ	JJ	_	14	amod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	FUra	fura	NN	NN	_	18	compound	_	_
18	chemotherapy	chemotherapy	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	immediate-early	immediate-early	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	induced	induce	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	adherent	adherent	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	encodes	encode	VBZ	VBZ	_	5	acl:relcl	_	_
12	I	i	NN	NN	_	14	nmod:npmod	_	_
13	kappa	kappa	NN	NN	_	14	nmod:npmod	_	_
14	B-like	b-like	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	group	group	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cDNAs	cdna	NNS	NNS	_	5	nmod	_	_
8	representing	represent	VBG	VBG	_	7	acl	_	_
9	mRNAs	mrna	NNS	NNS	_	8	dobj	_	_
10	that	that	WDT	WDT	_	13	nsubjpass	_	_
11	are	be	VBP	VBP	_	13	auxpass	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	induced	induce	VBN	VBN	_	9	acl:relcl	_	_
14	following	follow	VBG	VBG	_	15	case	_	_
15	adherence	adherence	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	induced	induce	VBN	VBN	_	5	amod	_	_
5	transcripts	transcript	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MAD-3	mad-3	NN	NN	_	1	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	encodes	encode	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	317	317	CD	CD	_	15	nummod	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	11	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	one	one	CD	CD	_	18	nummod	_	_
18	domain	domain	NN	NN	_	11	nmod	_	_
19	containing	contain	VBG	VBG	_	18	acl	_	_
20	five	five	CD	CD	_	22	nummod	_	_
21	tandem	tandem	JJ	JJ	_	22	amod	_	_
22	repeats	repeat	NNS	NNS	_	19	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cdc10/ankyrin	cdc10/ankyrin	JJ	JJ	_	26	amod	_	_
26	motif	motif	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	11	punct	_	_
28	which	which	WDT	WDT	_	32	nsubj	_	_
29	is	be	VBZ	VBZ	_	32	cop	_	_
30	60	60	CD	CD	_	31	nummod	_	_
31	%	%	NN	NN	_	32	nmod:npmod	_	_
32	similar	similar	JJ	JJ	_	11	acl:relcl	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	46	46	CD	CD	_	35	nummod	_	_
35	%	%	NN	NN	_	36	nmod:npmod	_	_
36	identical	identical	JJ	JJ	_	32	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	to	to	TO	TO	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	ankyrin	ankyrin	NN	NN	_	42	compound	_	_
41	repeat	repeat	NN	NN	_	42	compound	_	_
42	region	region	NN	NN	_	32	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	precursor	precursor	NN	NN	_	42	nmod	_	_
46	of	of	IN	IN	_	49	case	_	_
47	NF-kappa	nf-kappa	NN	NN	_	49	compound	_	_
48	B/KBF1	b/kbf1	NN	NN	_	49	compound	_	_
49	p50	p50	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	C-terminus	c-terminus	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	10	det	_	_
5	putative	putative	JJ	JJ	_	10	amod	_	_
6	protein	protein	NN	NN	_	10	compound	_	_
7	kinase	kinase	NN	NN	_	10	compound	_	_
8	C	c	NN	NN	_	10	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	3	dobj	_	_
11	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	3	advmod	_	_
3	translated	translate	VBN	VBN	_	5	amod	_	_
4	MAD-3	mad-3	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	inhibit	inhibit	VB	VB	_	7	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	p50/p65	p50/p65	NN	NN	_	19	compound	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	13	nmod	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	13	cc	_	_
22	that	that	DT	DT	_	13	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	p50/p50	p50/p50	NN	NN	_	27	compound	_	_
26	KBF1	kbf1	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	22	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	of	of	IN	IN	_	32	case	_	_
30	other	other	JJ	JJ	_	32	amod	_	_
31	DNA-binding	dna-binding	JJ	JJ	_	32	amod	_	_
32	proteins	protein	NNS	NNS	_	27	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	MAD-3	mad-3	NN	NN	_	3	compound	_	_
3	cDNA	cdna	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	9	det	_	_
6	I	i	NN	NN	_	8	nmod:npmod	_	_
7	kappa	kappa	NN	NN	_	8	nmod:npmod	_	_
8	B-like	b-like	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	4	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	likely	likely	JJ	JJ	_	9	acl:relcl	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	12	xcomp	_	_
16	in	in	IN	IN	_	17	case	_	_
17	regulation	regulation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	responses	response	NNS	NNS	_	17	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	including	include	VBG	VBG	_	27	case	_	_
26	adhesion-dependent	adhesion-dependent	JJ	JJ	_	27	amod	_	_
27	pathways	pathway	NNS	NNS	_	17	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	monocyte	monocyte	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	intermediates	intermediate	NNS	NNS	_	0	root	_	_
4	as	as	IN	IN	_	7	case	_	_
5	apparently	apparently	RB	RB	_	7	advmod	_	_
6	widely	widely	RB	RB	_	7	advmod	_	_
7	used	use	VBN	VBN	_	3	acl	_	_
8	messengers	messenger	NNS	NNS	_	7	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	3	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HIV-1	hiv-1	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Hydrogen	hydrogen	NN	NN	_	2	compound	_	_
2	peroxide	peroxide	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	oxygen	oxygen	NN	NN	_	2	conj	_	_
5	radicals	radical	NNS	NNS	_	7	nsubj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	agents	agent	NNS	NNS	_	0	root	_	_
8	commonly	commonly	RB	RB	_	9	advmod	_	_
9	produced	produce	VBN	VBN	_	7	dep	_	_
10	during	during	IN	IN	_	12	case	_	_
11	inflammatory	inflammatory	JJ	JJ	_	12	amod	_	_
12	processes	process	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	micromolar	micromolar	JJ	JJ	_	9	amod	_	_
9	concentrations	concentration	NNS	NNS	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	H2O2	h2o2	NN	NN	_	9	nmod	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	induce	induce	VB	VB	_	6	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	replication	replication	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HIV-1	hiv-1	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	4	nmod	_	_
11	which	which	WDT	WDT	_	16	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	16	auxpass	_	_
13	potently	potently	RB	RB	_	14	advmod	_	_
14	and	and	CC	CC	_	16	advmod	_	_
15	rapidly	rapidly	RB	RB	_	14	advmod	_	_
16	activated	activate	VBN	VBN	_	10	acl:relcl	_	_
17	by	by	IN	IN	_	16	dep	_	_
18	an	a	DT	DT	_	20	det	_	_
19	H2O2	h2o2	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cells	cell	NNS	NNS	_	20	nmod	_	_
23	from	from	IN	IN	_	27	case	_	_
24	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
25	inactive	inactive	JJ	JJ	_	27	amod	_	_
26	cytoplasmic	cytoplasmic	JJ	JJ	_	27	amod	_	_
27	form	form	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	25	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	NAC	nac	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	well	well	RB	RB	_	8	advmod	_	_
8	characterized	characterize	VBN	VBN	_	9	amod	_	_
9	antioxidant	antioxidant	NN	NN	_	1	appos	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	counteracts	counteract	VBZ	VBZ	_	9	acl:relcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	reactive	reactive	JJ	JJ	_	17	amod	_	_
16	oxygen	oxygen	NN	NN	_	17	compound	_	_
17	intermediates	intermediate	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ROI	roi	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	23	case	_	_
22	living	live	VBG	VBG	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	13	nmod	_	_
24	,	,	,	,	_	1	punct	_	_
25	prevented	prevent	VBD	VBD	_	0	root	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	nmod	_	_
31	by	by	IN	IN	_	32	case	_	_
32	H2O2	h2o2	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	25	punct	_	_

1	NAC	nac	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	other	other	JJ	JJ	_	5	amod	_	_
4	thiol	thiol	JJ	JJ	_	5	amod	_	_
5	compounds	compound	NNS	NNS	_	1	conj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	blocked	block	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	cycloheximide	cycloheximide	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	double-stranded	double-stranded	JJ	JJ	_	17	amod	_	_
17	RNA	rna	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	ionophore	ionophore	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	14	conj	_	_
23	,	,	,	,	_	14	punct	_	_
24	active	active	JJ	JJ	_	26	amod	_	_
25	phorbol	phorbol	NN	NN	_	26	compound	_	_
26	ester	ester	NN	NN	_	14	conj	_	_
27	,	,	,	,	_	14	punct	_	_
28	interleukin-1	interleukin-1	NN	NN	_	14	conj	_	_
29	,	,	,	,	_	14	punct	_	_
30	lipopolysaccharide	lipopolysaccharide	NN	NN	_	14	conj	_	_
31	and	and	CC	CC	_	14	cc	_	_
32	lectin	lectin	NN	NN	_	14	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	diverse	diverse	JJ	JJ	_	5	amod	_	_
5	agents	agent	NNS	NNS	_	17	nsubj	_	_
6	thought	think	VBN	VBN	_	5	acl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	activate	activate	VB	VB	_	6	xcomp	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	distinct	distinct	JJ	JJ	_	14	amod	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	pathways	pathway	NNS	NNS	_	8	nmod	_	_
15	might	might	MD	MD	_	17	aux	_	_
16	all	all	RB	RB	_	17	advmod	_	_
17	act	act	VB	VB	_	2	ccomp	_	_
18	through	through	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	common	common	JJ	JJ	_	21	amod	_	_
21	mechanism	mechanism	NN	NN	_	17	nmod	_	_
22	involving	involve	VBG	VBG	_	21	acl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	synthesis	synthesis	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	ROI	roi	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	ROI	roi	NN	NN	_	2	nsubj	_	_
2	appear	appear	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	serve	serve	VB	VB	_	2	xcomp	_	_
5	as	as	IN	IN	_	6	case	_	_
6	messengers	messenger	NNS	NNS	_	4	nmod	_	_
7	mediating	mediate	VBG	VBG	_	6	acl	_	_
8	directly	directly	RB	RB	_	9	advmod	_	_
9	or	or	CC	CC	_	7	advmod	_	_
10	indirectly	indirectly	RB	RB	_	9	advmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	release	release	NN	NN	_	7	dobj	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
16	subunit	subunit	NN	NN	_	19	compound	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	12	nmod	_	_
20	from	from	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	HTLV-1	htlv-1	NN	NN	_	2	compound	_	_
2	Tax	tax	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	various	various	JJ	JJ	_	11	amod	_	_
7	immediate	immediate	JJ	JJ	_	11	amod	_	_
8	early	early	JJ	JJ	_	11	amod	_	_
9	serum	serum	NN	NN	_	11	compound	_	_
10	responsive	responsive	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	4	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	13	nsubj	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-1	htlv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	etiological	etiological	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	17	case	_	_
15	adult	adult	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATL	atl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	showed	show	VBD	VBD	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	mobility-shift	mobility-shift	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	2	nmod	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	14	nsubj	_	_
10	transformed	transform	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	virus	virus	NN	NN	_	10	nmod	_	_
14	contained	contain	VBD	VBD	_	2	ccomp	_	_
15	high	high	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	AP-1	ap-1	NN	NN	_	19	compound	_	_
19	activities	activity	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Consistent	consistent	JJ	JJ	_	9	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	result	result	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	these	these	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	9	nsubj	_	_
9	expressed	express	VBD	VBD	_	0	root	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	levels	level	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	mRNAs	mrna	NNS	NNS	_	11	nmod	_	_
14	encoding	encode	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	AP-1	ap-1	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	14	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	c-Fos	c-fos	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	19	punct	_	_
21	Fra-1	fra-1	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	c-Jun	c-jun	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	JunB	junb	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	JunD	jund	NN	NN	_	19	conj	_	_
29	.	.	.	.	_	9	punct	_	_

1	Previously	previously	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	transcription	transcription	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	c-fos	c-fos	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	reported	report	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	transactivated	transactivate	VBN	VBN	_	10	xcomp	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	viral	viral	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	Tax1	tax1	NN	NN	_	18	appos	_	_
21	.	.	.	.	_	10	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	21	advcl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	2	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	JPX-9	jpx-9	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	18	nmod	_	_
13	expression	expression	NN	NN	_	18	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	Tax1	tax1	NN	NN	_	13	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	inducible	inducible	JJ	JJ	_	6	acl:relcl	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	showed	show	VBD	VBD	_	0	root	_	_
22	that	that	IN	IN	_	35	mark	_	_
23	expression	expression	NN	NN	_	35	nsubjpass	_	_
24	of	of	IN	IN	_	25	case	_	_
25	mRNAs	mrna	NNS	NNS	_	23	nmod	_	_
26	for	for	IN	IN	_	27	case	_	_
27	Fra-1	fra-1	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	c-Jun	c-jun	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	JunD	jund	NN	NN	_	27	conj	_	_
33	was	be	VBD	VBD	_	35	auxpass	_	_
34	also	also	RB	RB	_	35	advmod	_	_
35	transactivated	transactivate	VBN	VBN	_	21	ccomp	_	_
36	by	by	IN	IN	_	37	case	_	_
37	Tax1	tax1	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	21	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Tax1	tax1	NN	NN	_	4	nsubj	_	_
4	activated	activate	VBD	VBD	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	other	other	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	5	nmod	_	_
11	having	have	VBG	VBG	_	10	acl	_	_
12	zinc	zinc	NN	NN	_	14	compound	_	_
13	finger	finger	NN	NN	_	14	compound	_	_
14	motifs	motif	NNS	NNS	_	11	dobj	_	_
15	,	,	,	,	_	10	punct	_	_
16	Egr-1	egr-1	NN	NN	_	10	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Egr-2	egr-2	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	same	same	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	10	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Tax1-inducible	tax1-inducible	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	8	nsubjpass	_	_
5	identified	identify	VBN	VBN	_	4	acl	_	_
6	here	here	RB	RB	_	5	advmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	encoded	encode	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	members	member	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	immediate	immediate	JJ	JJ	_	15	amod	_	_
14	early	early	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	11	nmod	_	_
16	under	under	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	control	control	NN	NN	_	8	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	growth	growth	NN	NN	_	21	compound	_	_
21	signals	signal	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Tax1	tax1	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	suggested	suggest	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	replace	replace	VB	VB	_	5	xcomp	_	_
8	growth	growth	NN	NN	_	9	compound	_	_
9	signals	signal	NNS	NNS	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	at	at	IN	IN	_	14	advmod	_	_
12	least	least	JJS	JJS	_	11	mwe	_	_
13	in	in	IN	IN	_	14	case	_	_
14	part	part	NN	NN	_	7	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	by	by	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	mechanism	mechanism	NN	NN	_	7	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Differential	differential	JJ	JJ	_	3	amod	_	_
3	diagnostic	diagnostic	JJ	JJ	_	4	amod	_	_
4	value	value	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	receptors	receptor	NNS	NNS	_	4	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	calcitriol	calcitriol	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	determination	determination	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	children	child	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	rickets	rickets	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	rickets-like	rickets-like	JJ	JJ	_	22	amod	_	_
22	diseases	disease	NNS	NNS	_	19	conj	_	_
23	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	mark	_	_
7	studying	study	VBG	VBG	_	5	acl	_	_
8	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	7	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	calcitriol	calcitriol	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	children	child	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	rickets	rickets	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	rickets-like	rickets-like	JJ	JJ	_	21	amod	_	_
21	diseases	disease	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	proposed	propose	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	character	character	NN	NN	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	under	under	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	influence	influence	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	vitamin	vitamin	NN	NN	_	15	compound	_	_
15	D	d	NN	NN	_	12	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	used	use	VBN	VBN	_	3	ccomp	_	_
19	with	with	IN	IN	_	22	case	_	_
20	differential	differential	JJ	JJ	_	21	amod	_	_
21	diagnostic	diagnostic	JJ	JJ	_	22	amod	_	_
22	purposes	purpose	NNS	NNS	_	18	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	view	view	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Contribution	contribution	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Sp1	sp1	NN	NN	_	4	conj	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	motifs	motif	NNS	NNS	_	1	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	replicative	replicative	JJ	JJ	_	12	amod	_	_
12	capacity	capacity	NN	NN	_	1	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
16	virus	virus	NN	NN	_	17	compound	_	_
17	type	type	NN	NN	_	12	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	:	:	:	:	_	1	punct	_	_
20	distinct	distinct	JJ	JJ	_	21	amod	_	_
21	patterns	pattern	NNS	NNS	_	26	nsubjpass	_	_
22	of	of	IN	IN	_	24	case	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	growth	growth	NN	NN	_	21	nmod	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	determined	determine	VBN	VBN	_	1	dep	_	_
27	by	by	IN	IN	_	29	case	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	types	type	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	26	punct	_	_

1	Starting	start	VBG	VBG	_	49	advcl	_	_
2	with	with	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	replication-incompetent	replication-incompetent	JJ	JJ	_	6	amod	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	clone	clone	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	6	nmod	_	_
12	1	1	CD	CD	_	11	nummod	_	_
13	,	,	,	,	_	6	punct	_	_
14	lacking	lack	VBG	VBG	_	6	acl	_	_
15	all	all	PDT	PDT	_	22	det:predet	_	_
16	the	the	DT	DT	_	22	det	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	22	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Sp1	sp1	NN	NN	_	18	conj	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	14	dobj	_	_
23	present	present	JJ	JJ	_	22	amod	_	_
24	in	in	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	native	native	JJ	JJ	_	29	amod	_	_
27	long	long	JJ	JJ	_	29	amod	_	_
28	terminal	terminal	JJ	JJ	_	29	amod	_	_
29	repeat	repeat	NN	NN	_	23	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	LTR	ltr	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	49	punct	_	_
34	proviruses	provirus	NNS	NNS	_	49	nsubjpass	_	_
35	containing	contain	VBG	VBG	_	34	acl	_	_
36	reconstructed	reconstruct	VBN	VBN	_	37	amod	_	_
37	LTRs	ltr	NNS	NNS	_	35	dobj	_	_
38	with	with	IN	IN	_	39	case	_	_
39	individual	individual	JJ	JJ	_	37	nmod	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	combinations	combination	NNS	NNS	_	39	conj	_	_
42	of	of	IN	IN	_	41	acl	_	_
43	NF-kappa	nf-kappa	NN	NN	_	44	compound	_	_
44	B	b	NN	NN	_	47	compound	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	Sp1	sp1	NN	NN	_	44	conj	_	_
47	elements	element	NNS	NNS	_	39	dep	_	_
48	were	be	VBD	VBD	_	49	auxpass	_	_
49	generated	generate	VBN	VBN	_	0	root	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	evaluated	evaluate	VBN	VBN	_	49	conj	_	_
52	for	for	IN	IN	_	54	case	_	_
53	their	they	PRP$	PRP$	_	54	nmod:poss	_	_
54	capacity	capacity	NN	NN	_	51	nmod	_	_
55	to	to	TO	TO	_	56	mark	_	_
56	produce	produce	VB	VB	_	54	acl	_	_
57	virus	virus	NN	NN	_	58	compound	_	_
58	progeny	progeny	NN	NN	_	56	dobj	_	_
59	following	follow	VBG	VBG	_	60	case	_	_
60	transfection-cocultivation	transfection-cocultivation	NN	NN	_	56	nmod	_	_
61	.	.	.	.	_	49	punct	_	_

1	Virus	virus	NN	NN	_	2	compound	_	_
2	stocks	stock	NNS	NNS	_	7	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	experiments	experiment	NNS	NNS	_	3	nmod	_	_
7	exhibited	exhibit	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	continuum	continuum	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	replicative	replicative	JJ	JJ	_	12	amod	_	_
12	capacities	capacity	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	different	different	JJ	JJ	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	types	type	NNS	NNS	_	9	nmod	_	_
18	depending	depend	VBG	VBG	_	26	dep	_	_
19	on	on	IN	IN	_	26	mark	_	_
20	which	which	WDT	WDT	_	23	det	_	_
21	element	element	NN	NN	_	23	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	s	s	NNS	NNS	_	26	nsubj	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	was	be	VBD	VBD	_	26	cop	_	_
26	present	present	JJ	JJ	_	7	advcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	LTR	ltr	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	example	example	NN	NN	_	51	nmod	_	_
3	,	,	,	,	_	51	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	experiments	experiment	NNS	NNS	_	51	nmod	_	_
6	involving	involve	VBG	VBG	_	5	acl	_	_
7	proviral	proviral	JJ	JJ	_	8	amod	_	_
8	clones	clone	NNS	NNS	_	6	dobj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	LTRs	ltr	NNS	NNS	_	8	nmod	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	one	one	CD	CD	_	17	nummod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	two	two	CD	CD	_	12	conj	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	elements	element	NNS	NNS	_	11	dobj	_	_
18	(	(	-LRB-	-LRB-	_	17	punct	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	no	no	DT	DT	_	23	neg	_	_
21	Sp1	sp1	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	17	conj	_	_
24	)	)	-RRB-	-RRB-	_	17	punct	_	_
25	,	,	,	,	_	51	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	hierarchy	hierarchy	NN	NN	_	51	nsubjpass	_	_
28	of	of	IN	IN	_	30	case	_	_
29	cellular	cellular	JJ	JJ	_	30	amod	_	_
30	permissivity	permissivity	NN	NN	_	27	nmod	_	_
31	to	to	TO	TO	_	33	case	_	_
32	virus	virus	NN	NN	_	33	compound	_	_
33	replication	replication	NN	NN	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	38	punct	_	_
35	peripheral	peripheral	JJ	JJ	_	37	amod	_	_
36	blood	blood	NN	NN	_	37	compound	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	38	nsubj	_	_
38	=	=	JJ	JJ	_	27	dep	_	_
39	MT4	mt4	NN	NN	_	38	dobj	_	_
40	greater	greater	JJR	JJR	_	39	amod	_	_
41	than	than	IN	IN	_	42	case	_	_
42	H9	h9	NN	NN	_	40	nmod	_	_
43	greater	greater	JJR	JJR	_	42	amod	_	_
44	than	than	IN	IN	_	45	case	_	_
45	CEM	cem	NN	NN	_	43	nmod	_	_
46	greater	greater	JJR	JJR	_	45	amod	_	_
47	than	than	IN	IN	_	48	case	_	_
48	Jurkat	jurkat	NN	NN	_	46	nmod	_	_
49	)	)	-RRB-	-RRB-	_	38	punct	_	_
50	was	be	VBD	VBD	_	51	auxpass	_	_
51	observed	observe	VBN	VBN	_	0	root	_	_
52	.	.	.	.	_	51	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	note	note	NN	NN	_	3	nmod	_	_
3	was	be	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	associated	associate	VBN	VBN	_	6	amod	_	_
6	emergence	emergence	NN	NN	_	3	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	second-site	second-site	JJ	JJ	_	10	amod	_	_
9	LTR	ltr	NN	NN	_	10	compound	_	_
10	revertants	revertant	NNS	NNS	_	6	nmod	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	involved	involve	VBD	VBD	_	6	acl:relcl	_	_
13	an	a	DT	DT	_	14	det	_	_
14	alteration	alteration	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	TATA	tata	NN	NN	_	18	compound	_	_
18	box	box	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	11	det	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
8	virus	virus	NN	NN	_	11	compound	_	_
9	type	type	NN	NN	_	11	compound	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	LTR	ltr	NN	NN	_	12	nsubj	_	_
12	possesses	possess	VBZ	VBZ	_	3	ccomp	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	redundancy	redundancy	NN	NN	_	12	dobj	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	ensures	ensure	VBZ	VBZ	_	14	acl:relcl	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	replication	replication	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	different	different	JJ	JJ	_	22	amod	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	types	type	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	capable	capable	JJ	JJ	_	12	conj	_	_
26	of	of	IN	IN	_	27	mark	_	_
27	changing	change	VBG	VBG	_	25	advcl	_	_
28	depending	depend	VBG	VBG	_	32	case	_	_
29	on	on	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	particular	particular	JJ	JJ	_	32	amod	_	_
32	combination	combination	NN	NN	_	25	advcl	_	_
33	of	of	IN	IN	_	35	case	_	_
34	transcriptional	transcriptional	JJ	JJ	_	35	amod	_	_
35	factors	factor	NNS	NNS	_	32	nmod	_	_
36	present	present	JJ	JJ	_	35	amod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Enhancement	enhancement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	human	human	JJ	JJ	_	7	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
5	virus	virus	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	replication	replication	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	1,25-dihydroxycholecalciferol	1,25-dihydroxycholecalciferol	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	compound	_	_
3	virus	virus	NN	NN	_	14	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	HIV	hiv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	expression	expression	NN	NN	_	3	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	replication	replication	NN	NN	_	7	conj	_	_
10	are	be	VBP	VBP	_	14	cop	_	_
11	under	under	IN	IN	_	14	case	_	_
12	tight	tight	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	control	control	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	1,25-dihydroxycholecalciferol	1,25-dihydroxycholecalciferol	NN	NN	_	8	nsubj	_	_
5	-LSB-	-lsb-	-LRB-	-LRB-	_	6	punct	_	_
6	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	4	appos	_	_
7	-RSB-	-rsb-	-RRB-	-RRB-	_	6	punct	_	_
8	enhances	enhance	VBZ	VBZ	_	2	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	replication	replication	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	monocyte-	monocyte-	NN	NN	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	lymphocyte-tropic	lymphocyte-tropic	JJ	JJ	_	12	conj	_	_
15	strains	strain	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HIV-1	hiv-1	NN	NN	_	15	nmod	_	_
18	up	up	IN	IN	_	20	case	_	_
19	to	to	TO	TO	_	20	case	_	_
20	10,000-fold	10,000-fold	RB	RB	_	8	advcl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	monocyte	monocyte	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	8	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
27	blood	blood	NN	NN	_	28	compound	_	_
28	monocytes	monocyte	NNS	NNS	_	24	conj	_	_
29	,	,	,	,	_	24	punct	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	unfractionated	unfractionated	JJ	JJ	_	35	amod	_	_
32	peripheral	peripheral	JJ	JJ	_	35	amod	_	_
33	blood	blood	NN	NN	_	35	compound	_	_
34	mononuclear	mononuclear	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	24	conj	_	_
36	.	.	.	.	_	2	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	one	one	CD	CD	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	most	most	RBS	RBS	_	8	advmod	_	_
8	potent	potent	JJ	JJ	_	9	amod	_	_
9	regulators	regulator	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	replication	replication	NN	NN	_	9	nmod	_	_
13	described	describe	VBN	VBN	_	9	acl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	date	date	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Precursors	precursor	NNS	NNS	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	1	nmod	_	_
4	enhance	enhance	VBP	VBP	_	0	root	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	proportion	proportion	NN	NN	_	11	dep	_	_
9	to	to	TO	TO	_	11	case	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	affinity	affinity	NN	NN	_	4	nmod	_	_
12	for	for	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	16	compound	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	receptor	receptor	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	21	nsubj	_	_
21	influences	influence	VBZ	VBZ	_	18	ccomp	_	_
22	HIV-1	hiv-1	NN	NN	_	23	compound	_	_
23	replication	replication	NN	NN	_	21	dobj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	mechanisms	mechanism	NNS	NNS	_	21	nmod	_	_
26	involving	involve	VBG	VBG	_	25	acl	_	_
27	this	this	DT	DT	_	28	det	_	_
28	receptor	receptor	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	implications	implication	NNS	NNS	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	design	design	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	effective	effective	JJ	JJ	_	12	amod	_	_
12	therapy	therapy	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	infection	infection	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HIV-1	hiv-1	NN	NN	_	4	compound	_	_
4	replication	replication	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	conj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	cysteine	cysteine	NN	NN	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cysteine	cysteine	NN	NN	_	13	compound	_	_
13	derivatives	derivative	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	1	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
2	proviral	proviral	JJ	JJ	_	3	amod	_	_
3	DNA	dna	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	sites	site	NNS	NNS	_	4	dobj	_	_
8	for	for	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	transcription	transcription	NN	NN	_	13	compound	_	_
11	factor	factor	NN	NN	_	13	compound	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	HIV-1-infected	hiv-1-infected	JJ	JJ	_	2	amod	_	_
2	individuals	individual	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	on	on	IN	IN	_	6	case	_	_
6	average	average	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	abnormally	abnormally	RB	RB	_	9	advmod	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	3	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	tumour	tumour	NN	NN	_	15	compound	_	_
13	necrosis	necrosis	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	TNF	tnf	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	abnormally	abnormally	RB	RB	_	22	advmod	_	_
22	low	low	JJ	JJ	_	25	amod	_	_
23	plasma	plasma	NN	NN	_	25	compound	_	_
24	cysteine	cysteine	NN	NN	_	25	compound	_	_
25	levels	level	NNS	NNS	_	10	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cysteine	cysteine	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	related	related	JJ	JJ	_	10	amod	_	_
10	thiols	thiol	NNS	NNS	_	7	conj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	5	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	report	report	NN	NN	_	2	nmod	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	cysteine	cysteine	NN	NN	_	14	nsubj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	N-acetylcysteine	n-acetylcysteine	NN	NN	_	8	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	NAC	nac	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	raise	raise	VBP	VBP	_	6	ccomp	_	_
15	the	the	DT	DT	_	21	det	_	_
16	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
17	glutathione	glutathione	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	GSH	gsh	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	level	level	NN	NN	_	14	dobj	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	inhibit	inhibit	VBP	VBP	_	14	conj	_	_
24	HIV-1	hiv-1	NN	NN	_	25	compound	_	_
25	replication	replication	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	32	case	_	_
27	persistently	persistently	RB	RB	_	28	advmod	_	_
28	infected	infected	JJ	JJ	_	32	amod	_	_
29	Molt-4	molt-4	NN	NN	_	32	compound	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	U937	u937	NN	NN	_	29	conj	_	_
32	cells	cell	NNS	NNS	_	14	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	3	nmod	_	_
7	appears	appear	VBZ	VBZ	_	0	root	_	_
8	not	not	RB	RB	_	12	neg	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	auxpass	_	_
11	directly	directly	RB	RB	_	12	advmod	_	_
12	correlated	correlate	VBN	VBN	_	7	dep	_	_
13	with	with	IN	IN	_	15	case	_	_
14	GSH	gsh	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Cysteine	cysteine	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	NAC	nac	NN	NN	_	1	conj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	as	as	IN	IN	_	10	mark	_	_
10	determined	determine	VBN	VBN	_	8	dep	_	_
11	by	by	IN	IN	_	15	case	_	_
12	electrophoretic	electrophoretic	JJ	JJ	_	15	amod	_	_
13	mobility	mobility	NN	NN	_	15	compound	_	_
14	shift	shift	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	chloramphenicol	chloramphenicol	NN	NN	_	18	compound	_	_
18	acetyl-transferase	acetyl-transferase	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	CAT	cat	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	8	conj	_	_
24	under	under	IN	IN	_	25	case	_	_
25	control	control	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	sites	site	NNS	NNS	_	25	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	uninfected	uninfected	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	cysteine	cysteine	NN	NN	_	6	compound	_	_
6	deficiency	deficiency	NN	NN	_	11	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	HIV-1-infected	hiv-1-infected	JJ	JJ	_	9	amod	_	_
9	individuals	individual	NNS	NNS	_	6	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	cause	cause	VB	VB	_	2	ccomp	_	_
12	an	a	DT	DT	_	13	det	_	_
13	over-expression	over-expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	nmod:npmod	_	_
16	B-dependent	b-dependent	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	enhance	enhance	VB	VB	_	11	conj	_	_
20	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
21	replication	replication	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	2	punct	_	_

1	NAC	nac	NN	NN	_	4	nsubjpass	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	considered	consider	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	treatment	treatment	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV-1-infected	hiv-1-infected	JJ	JJ	_	10	amod	_	_
10	individuals	individual	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	systemic	systemic	JJ	JJ	_	6	amod	_	_
5	lupus	lupus	NN	NN	_	6	compound	_	_
6	erythematosus	erythematosus	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Glucocorticosteroids	glucocorticosteroid	NNS	NNS	_	2	nsubj	_	_
2	remain	remain	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	major	major	JJ	JJ	_	6	amod	_	_
5	treatment	treatment	NN	NN	_	6	compound	_	_
6	modality	modality	NN	NN	_	2	xcomp	_	_
7	for	for	IN	IN	_	10	case	_	_
8	systemic	systemic	JJ	JJ	_	10	amod	_	_
9	lupus	lupus	NN	NN	_	10	compound	_	_
10	erythematosus	erythematosus	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SLE	sle	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	2	punct	_	_
15	but	but	CC	CC	_	2	cc	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	mechanism	mechanism	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	action	action	NN	NN	_	17	nmod	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	unclear	unclear	JJ	JJ	_	2	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Over	over	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	past	past	JJ	JJ	_	4	amod	_	_
4	decade	decade	NN	NN	_	7	nmod	_	_
5	it	it	PRP	PRP	_	7	nsubj	_	_
6	has	have	VBZ	VBZ	_	7	aux	_	_
7	become	become	VBN	VBN	_	0	root	_	_
8	clear	clear	JJ	JJ	_	7	xcomp	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	glucocorticosteroid	glucocorticosteroid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	12	nsubj	_	_
12	play	play	VBP	VBP	_	7	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	mechanism	mechanism	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	glucocorticosteroid	glucocorticosteroid	NN	NN	_	21	compound	_	_
21	action	action	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	glucocorticosteroid	glucocorticosteroid	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	2	dobj	_	_
5	density	density	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	affinity	affinity	NN	NN	_	5	conj	_	_
8	on	on	IN	IN	_	12	case	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	by	by	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	glucocorticosteroid	glucocorticosteroid	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	assay	assay	NN	NN	_	2	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	33	33	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	2	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	SLE	sle	NN	NN	_	20	nmod	_	_
23	who	who	WP	WP	_	25	nsubj	_	_
24	had	have	VBD	VBD	_	25	aux	_	_
25	taken	take	VBN	VBN	_	20	acl:relcl	_	_
26	no	no	DT	DT	_	27	neg	_	_
27	glucocorticosteroid	glucocorticosteroid	NN	NN	_	25	dobj	_	_
28	for	for	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	previous	previous	JJ	JJ	_	32	amod	_	_
31	6	6	CD	CD	_	32	nummod	_	_
32	months	month	NNS	NNS	_	25	nmod	_	_
33	and	and	CC	CC	_	20	cc	_	_
34	in	in	IN	IN	_	37	case	_	_
35	32	32	CD	CD	_	37	nummod	_	_
36	healthy	healthy	JJ	JJ	_	37	amod	_	_
37	controls	control	NNS	NNS	_	20	conj	_	_
38	.	.	.	.	_	2	punct	_	_

1	Patients	patient	NNS	NNS	_	4	nmod:poss	_	_
2	'	'	POS	POS	_	1	case	_	_
3	disease	disease	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	measured	measure	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	SLE	sle	NN	NN	_	12	compound	_	_
10	Disease	disease	NN	NN	_	12	compound	_	_
11	Activity	activity	NN	NN	_	12	compound	_	_
12	Index	index	NN	NN	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SLEDAI	sledai	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	6	punct	_	_

1	Glucocorticosteroid	glucocorticosteroid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	11	nsubj	_	_
3	on	on	IN	IN	_	4	case	_	_
4	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	SLE	sle	NN	NN	_	6	acl	_	_
9	were	be	VBD	VBD	_	11	cop	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	higher	higher	JJR	JJR	_	0	root	_	_
12	than	than	IN	IN	_	15	case	_	_
13	in	in	IN	IN	_	15	case	_	_
14	healthy	healthy	JJ	JJ	_	15	amod	_	_
15	controls	control	NNS	NNS	_	11	advcl	_	_
16	(	(	-LRB-	-LRB-	_	26	punct	_	_
17	4419	4419	CD	CD	_	26	dep	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	306	306	CD	CD	_	17	conj	_	_
20	vs	vs	CC	CC	_	17	cc	_	_
21	3369	3369	CD	CD	_	17	conj	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	196	196	CD	CD	_	21	conj	_	_
24	,	,	,	,	_	26	punct	_	_
25	p	p	NN	NN	_	26	dep	_	_
26	less	less	JJR	JJR	_	11	dep	_	_
27	than	than	IN	IN	_	28	case	_	_
28	0.005	0.005	CD	CD	_	26	nmod	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	affinity	affinity	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	different	different	JJ	JJ	_	0	root	_	_
7	between	between	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	controls	control	NNS	NNS	_	8	conj	_	_
11	.	.	.	.	_	6	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	correlation	correlation	NN	NN	_	2	nsubj	_	_
5	between	between	IN	IN	_	8	case	_	_
6	glucocorticosteroid	glucocorticosteroid	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	number	number	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	SLE	sle	NN	NN	_	12	compound	_	_
11	disease	disease	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Changes	change	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	leucocytic	leucocytic	JJ	JJ	_	7	amod	_	_
5	estrogen	estrogen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	gynecomastia	gynecomastia	NN	NN	_	9	nmod	_	_
12	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	estrogen	estrogen	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ER	er	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	leucocytes	leucocyte	NNS	NNS	_	5	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	13	13	CD	CD	_	15	nummod	_	_
15	men	man	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	gynecomastia	gynecomastium	NNS	NNS	_	15	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	measured	measure	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	23	case	_	_
21	radioligand	radioligand	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	method	method	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	compared	compare	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	those	those	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	13	13	CD	CD	_	13	nummod	_	_
9	sex-	sex-	NN	NN	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	age-matched	age-matched	JJ	JJ	_	9	conj	_	_
12	healthy	healthy	JJ	JJ	_	13	amod	_	_
13	subjects	subject	NNS	NNS	_	6	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ER	er	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	leucocytes	leucocyte	NNS	NNS	_	8	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	increased	increase	VBN	VBN	_	3	ccomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	gynecomastia	gynecomastia	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	24	punct	_	_
17	Rs	rs	NN	NN	_	24	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	leucocytes	leucocyte	NNS	NNS	_	17	nmod	_	_
20	were	be	VBD	VBD	_	24	cop	_	_
21	1054	1054	CD	CD	_	24	nummod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	254	254	CD	CD	_	21	conj	_	_
24	sites/cell	sites/cell	NN	NN	_	13	parataxis	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	suggested	suggest	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	increase	increase	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	ER	er	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	4	nmod	_	_
8	play	play	VBP	VBP	_	2	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pathogenesis	pathogenesis	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	gynecomastia	gynecomastia	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Changes	change	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	levels	level	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	leucocytic	leucocytic	JJ	JJ	_	8	amod	_	_
7	estrogen	estrogen	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	15	case	_	_
12	menopausal	menopausal	JJ	JJ	_	15	amod	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	diabetes	diabetes	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	significance	significance	NN	NN	_	2	conj	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	22	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	estrogen	estrogen	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ER	er	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	leucocytes	leucocyte	NNS	NNS	_	5	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	12	12	CD	CD	_	15	nummod	_	_
15	women	woman	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	20	case	_	_
17	menopausal	menopausal	JJ	JJ	_	20	amod	_	_
18	type	type	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	diabetes	diabetes	NNS	NNS	_	15	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	measured	measure	VBN	VBN	_	0	root	_	_
23	with	with	IN	IN	_	26	case	_	_
24	radio-ligand	radio-ligand	JJ	JJ	_	26	amod	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	method	method	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	compared	compare	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	those	those	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	12	12	CD	CD	_	10	nummod	_	_
9	menopausal	menopausal	JJ	JJ	_	10	amod	_	_
10	women	woman	NNS	NNS	_	6	nmod	_	_
11	without	without	IN	IN	_	12	case	_	_
12	diabetes	diabetes	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	12	12	CD	CD	_	16	nummod	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	women	woman	NNS	NNS	_	10	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	childbearing	childbearing	JJ	JJ	_	19	amod	_	_
19	age	age	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ER	er	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	decreased	decrease	VBN	VBN	_	3	ccomp	_	_
15	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	decrease	decrease	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	ER	er	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	related	related	JJ	JJ	_	3	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pathogenesis	pathogenesis	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	type	type	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	diabetes	diabetes	NNS	NNS	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	menopausal	menopausal	JJ	JJ	_	23	amod	_	_
23	period	period	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	0	root	_	_
5	during	during	IN	IN	_	6	case	_	_
6	depression	depression	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	after	after	IN	IN	_	10	case	_	_
9	clinical	clinical	JJ	JJ	_	10	amod	_	_
10	recovery	recovery	NN	NN	_	6	conj	_	_
11	.	.	.	.	_	4	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
3	receptor	receptor	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	parameters	parameter	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	studied	study	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	15	15	CD	CD	_	12	nummod	_	_
10	severely	severely	RB	RB	_	11	advmod	_	_
11	depressed	depressed	JJ	JJ	_	12	amod	_	_
12	patients	patient	NNS	NNS	_	7	nmod	_	_
13	during	during	IN	IN	_	14	case	_	_
14	depression	depression	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	after	after	IN	IN	_	18	case	_	_
17	clinical	clinical	JJ	JJ	_	18	amod	_	_
18	recovery	recovery	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	7	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	in	in	IN	IN	_	24	case	_	_
22	15	15	CD	CD	_	24	nummod	_	_
23	healthy	healthy	JJ	JJ	_	24	amod	_	_
24	controls	control	NNS	NNS	_	7	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	difference	difference	NN	NN	_	2	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	nmod	_	_
8	number	number	NN	NN	_	7	dep	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	affinity	affinity	NN	NN	_	8	conj	_	_
11	between	between	IN	IN	_	13	case	_	_
12	depressed	depressed	JJ	JJ	_	13	amod	_	_
13	patients	patient	NNS	NNS	_	4	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	recovered	recovered	JJ	JJ	_	18	amod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	control	control	NN	NN	_	15	conj	_	_
18	subjects	subject	NNS	NNS	_	13	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	Afternoon	afternoon	NN	NN	_	5	compound	_	_
2	ACTH	acth	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cortisol	cortisol	NN	NN	_	2	conj	_	_
5	concentrations	concentration	NNS	NNS	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	differ	differ	VB	VB	_	0	root	_	_
9	significantly	significantly	RB	RB	_	8	advmod	_	_
10	between	between	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	three	three	CD	CD	_	13	nummod	_	_
13	groups	group	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	relationship	relationship	NN	NN	_	5	nsubjpass	_	_
3	could	could	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	established	establish	VBN	VBN	_	0	root	_	_
6	between	between	IN	IN	_	9	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	antidepressant	antidepressant	JJ	JJ	_	12	amod	_	_
12	medication	medication	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	view	view	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	impaired	impaired	JJ	JJ	_	9	amod	_	_
9	ligand-induced	ligand-induced	JJ	JJ	_	10	amod	_	_
10	plasticity	plasticity	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	10	nmod	_	_
15	rather	rather	RB	RB	_	5	cc	_	_
16	than	than	IN	IN	_	15	mwe	_	_
17	the	the	DT	DT	_	18	det	_	_
18	hypothesis	hypothesis	NN	NN	_	5	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	decreased	decrease	VBN	VBN	_	23	amod	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	numbers	number	NNS	NNS	_	18	nmod	_	_
24	during	during	IN	IN	_	25	case	_	_
25	depression	depression	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	association	association	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	T-cell	t-cell	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	blocked	block	VBN	VBN	_	2	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	FK-506	fk-506	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cyclosporin	cyclosporin	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	10	conj	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	see	see	VB	VB	_	2	dep	_	_
16	comments	comment	NNS	NNS	_	15	dobj	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	FK506	fk506	NN	NN	_	2	conj	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	T-	t-	NN	NN	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	B-cell	b-cell	NN	NN	_	6	conj	_	_
9	activation	activation	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	processes	process	NNS	NNS	_	9	conj	_	_
13	essential	essential	JJ	JJ	_	9	amod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	effective	effective	JJ	JJ	_	18	amod	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
4	these	these	DT	DT	_	5	det	_	_
5	drugs	drug	NNS	NNS	_	6	nsubj	_	_
6	disrupt	disrupt	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	unknown	unknown	JJ	JJ	_	9	amod	_	_
9	step	step	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	transmission	transmission	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	signals	signal	NNS	NNS	_	12	nmod	_	_
15	from	from	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	antigen	antigen	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	12	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	cytokine	cytokine	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	12	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	coordinate	coordinate	VBP	VBP	_	22	acl:relcl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	immune	immune	JJ	JJ	_	27	amod	_	_
27	response	response	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	putative	putative	JJ	JJ	_	4	amod	_	_
3	intracellular	intracellular	JJ	JJ	_	4	amod	_	_
4	receptors	receptor	NNS	NNS	_	12	nsubj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	FK506	fk506	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	cyclosporin	cyclosporin	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	cis-trans	cis-trans	JJ	JJ	_	12	amod	_	_
11	prolyl	prolyl	JJ	JJ	_	12	amod	_	_
12	isomerases	isomerase	NNS	NNS	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Binding	binding	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	drug	drug	NN	NN	_	1	nmod	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	isomerase	isomerase	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	5	punct	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	studies	study	NNS	NNS	_	23	nsubj	_	_
11	with	with	IN	IN	_	15	case	_	_
12	other	other	JJ	JJ	_	15	amod	_	_
13	prolyl	prolyl	JJ	JJ	_	15	amod	_	_
14	isomerase	isomerase	NN	NN	_	15	compound	_	_
15	inhibitors	inhibitor	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	analysis	analysis	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	cyclosporin-resistant	cyclosporin-resistant	JJ	JJ	_	20	amod	_	_
20	mutants	mutant	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	yeast	yeast	NN	NN	_	20	nmod	_	_
23	suggest	suggest	VBP	VBP	_	5	conj	_	_
24	that	that	IN	IN	_	30	mark	_	_
25	the	the	DT	DT	_	26	det	_	_
26	effects	effect	NNS	NNS	_	30	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	drug	drug	NN	NN	_	26	nmod	_	_
30	result	result	VBP	VBP	_	23	ccomp	_	_
31	from	from	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	formation	formation	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	an	a	DT	DT	_	37	det	_	_
36	inhibitory	inhibitory	JJ	JJ	_	37	amod	_	_
37	complex	complex	NN	NN	_	33	nmod	_	_
38	between	between	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	drug	drug	NN	NN	_	33	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	isomerase	isomerase	NN	NN	_	40	conj	_	_
43	,	,	,	,	_	33	punct	_	_
44	and	and	CC	CC	_	33	cc	_	_
45	not	not	RB	RB	_	47	neg	_	_
46	from	from	IN	IN	_	47	case	_	_
47	inhibition	inhibition	NN	NN	_	33	conj	_	_
48	of	of	IN	IN	_	50	case	_	_
49	isomerase	isomerase	NN	NN	_	50	compound	_	_
50	activity	activity	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	NF-AT	nf-at	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	3	acl:relcl	_	_
10	for	for	IN	IN	_	14	case	_	_
11	early	early	JJ	JJ	_	14	amod	_	_
12	T-cell	t-cell	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	seems	seem	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	21	mark	_	_
18	be	be	VB	VB	_	21	cop	_	_
19	a	a	DT	DT	_	21	det	_	_
20	specific	specific	JJ	JJ	_	21	amod	_	_
21	target	target	NN	NN	_	16	xcomp	_	_
22	of	of	IN	IN	_	27	case	_	_
23	cyclosporin	cyclosporin	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	FK506	fk506	NN	NN	_	24	conj	_	_
27	action	action	NN	NN	_	21	nmod	_	_
28	because	because	IN	IN	_	35	mark	_	_
29	transcription	transcription	NN	NN	_	35	nsubjpass	_	_
30	directed	direct	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	protein	protein	NN	NN	_	30	nmod	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	blocked	block	VBN	VBN	_	21	advcl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	35	nmod	_	_
39	treated	treat	VBN	VBN	_	38	acl	_	_
40	with	with	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	drugs	drug	NNS	NNS	_	39	nmod	_	_
43	,	,	,	,	_	35	punct	_	_
44	with	with	IN	IN	_	48	case	_	_
45	little	little	JJ	JJ	_	48	nummod	_	_
46	or	or	CC	CC	_	45	cc	_	_
47	no	no	DT	DT	_	45	conj	_	_
48	effect	effect	NN	NN	_	35	nmod	_	_
49	on	on	IN	IN	_	52	case	_	_
50	other	other	JJ	JJ	_	52	amod	_	_
51	transcription	transcription	NN	NN	_	52	compound	_	_
52	factors	factor	NNS	NNS	_	48	nmod	_	_
53	such	such	JJ	JJ	_	55	case	_	_
54	as	as	IN	IN	_	53	mwe	_	_
55	AP-1	ap-1	NN	NN	_	52	nmod	_	_
56	and	and	CC	CC	_	55	cc	_	_
57	NF-kappa	nf-kappa	NN	NN	_	58	compound	_	_
58	B	b	NN	NN	_	55	conj	_	_
59	.	.	.	.	_	16	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	NF-AT	nf-at	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	formed	form	VBN	VBN	_	3	ccomp	_	_
8	when	when	WRB	WRB	_	15	advmod	_	_
9	a	a	DT	DT	_	10	det	_	_
10	signal	signal	NN	NN	_	15	nsubj	_	_
11	from	from	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	antigen	antigen	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	induces	induce	VBZ	VBZ	_	7	advcl	_	_
16	a	a	DT	DT	_	19	det	_	_
17	pre-existing	pre-existing	JJ	JJ	_	19	amod	_	_
18	cytoplasmic	cytoplasmic	JJ	JJ	_	19	amod	_	_
19	subunit	subunit	NN	NN	_	15	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	translocate	translocate	VB	VB	_	15	advcl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	nucleus	nucleus	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	combine	combine	VB	VB	_	15	conj	_	_
27	with	with	IN	IN	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	newly	newly	RB	RB	_	30	advmod	_	_
30	synthesized	synthesize	VBN	VBN	_	32	amod	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	subunit	subunit	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	NF-AT	nf-at	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	FK506	fk506	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cyclosporin	cyclosporin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	1	conj	_	_
5	block	block	VBP	VBP	_	0	root	_	_
6	translocation	translocation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	6	nmod	_	_
11	without	without	IN	IN	_	12	mark	_	_
12	affecting	affect	VBG	VBG	_	5	advcl	_	_
13	synthesis	synthesis	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	subunit	subunit	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	M-CSF	m-csf	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	M-CSF	m-csf	NN	NN	_	1	nmod	_	_
7	:	:	:	:	_	1	punct	_	_
8	role	role	NN	NN	_	1	dep	_	_
9	of	of	IN	IN	_	12	case	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	C	c	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	transcription	transcription	NN	NN	_	18	compound	_	_
15	factor	factor	NN	NN	_	18	compound	_	_
16	NF	nf	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	12	conj	_	_
19	.	.	.	.	_	8	punct	_	_

1	Macrophage-colony-stimulating	macrophage-colony-stimulating	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	13	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	M-CSF	m-csf	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	referred	refer	VBN	VBN	_	2	acl	_	_
9	to	to	TO	TO	_	8	nmod	_	_
10	as	as	IN	IN	_	11	case	_	_
11	CSF-1	csf-1	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	regulates	regulate	VBZ	VBZ	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	survival	survival	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	growth	growth	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	differentiation	differentiation	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	functional	functional	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	15	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	binding	bind	VBG	VBG	_	13	advcl	_	_
27	to	to	TO	TO	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	single	single	JJ	JJ	_	30	amod	_	_
30	class	class	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	high-affinity	high-affinity	JJ	JJ	_	35	amod	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	surface	surface	NN	NN	_	35	compound	_	_
35	receptors	receptor	NNS	NNS	_	30	nmod	_	_
36	,	,	,	,	_	30	punct	_	_
37	known	know	VBN	VBN	_	30	acl	_	_
38	to	to	TO	TO	_	41	mark	_	_
39	be	be	VB	VB	_	41	cop	_	_
40	the	the	DT	DT	_	41	det	_	_
41	product	product	NN	NN	_	37	xcomp	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	c-fms	c-fms	NN	NN	_	45	compound	_	_
45	protooncogene	protooncogene	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	detection	detection	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	M-CSF	m-csf	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-fms	c-fms	NN	NN	_	5	conj	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	cells	cell	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	monocyte	monocyte	NN	NN	_	14	compound	_	_
14	lineage	lineage	NN	NN	_	10	nmod	_	_
15	has	have	VBZ	VBZ	_	16	aux	_	_
16	suggested	suggest	VBN	VBN	_	0	root	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	M-CSF	m-csf	NN	NN	_	20	nsubj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	act	act	VB	VB	_	16	ccomp	_	_
21	by	by	IN	IN	_	24	case	_	_
22	an	a	DT	DT	_	24	det	_	_
23	autocrine	autocrine	JJ	JJ	_	24	amod	_	_
24	mechanism	mechanism	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Interestingly	interestingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	M-CSF	m-csf	NN	NN	_	10	nsubj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	induce	induce	VB	VB	_	6	ccomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	own	own	JJ	JJ	_	16	amod	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	sensitivity	sensitivity	NN	NN	_	7	nsubjpass	_	_
3	to	to	TO	TO	_	4	case	_	_
4	M-CSF	m-csf	NN	NN	_	2	nmod	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	modulated	modulate	VBN	VBN	_	20	advcl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	regulation	regulation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	receptor	receptor	NN	NN	_	9	nmod	_	_
12	expression	expression	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	function	function	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	20	punct	_	_
16	M-CSF	m-csf	NN	NN	_	17	compound	_	_
17	responsiveness	responsiveness	NN	NN	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	largely	largely	RB	RB	_	20	advmod	_	_
20	determined	determine	VBN	VBN	_	0	root	_	_
21	at	at	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	postreceptor	postreceptor	NN	NN	_	24	compound	_	_
24	level	level	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	To	to	TO	TO	_	2	case	_	_
2	date	date	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	little	little	JJ	JJ	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	0	root	_	_
7	about	about	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	pathway	pathway	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	M-CSF	m-csf	NN	NN	_	14	compound	_	_
13	signal	signal	NN	NN	_	14	compound	_	_
14	transduction	transduction	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	changes	change	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	14	case	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PKC	pkc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	activity	activity	NN	NN	_	6	nmod	_	_
15	upon	upon	IN	IN	_	16	case	_	_
16	exposure	exposure	NN	NN	_	6	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	M-CSF	m-csf	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	M-CSF	m-csf	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	translocates	translocate	VBZ	VBZ	_	5	conj	_	_
8	PKC	pkc	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PKC	pkc	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	isoquinoline	isoquinoline	NN	NN	_	8	compound	_	_
7	derivative	derivative	JJ	JJ	_	8	amod	_	_
8	H7	h7	NN	NN	_	1	nmod	_	_
9	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
10	induction	induction	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	M-CSF	m-csf	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	M-CSF	m-csf	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	activation	activation	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	PKC	pkc	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	pertussis-toxin-sensitive	pertussis-toxin-sensitive	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	7	conj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	detection	detection	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	an	a	DT	DT	_	19	det	_	_
16	NF	nf	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	13	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	extracts	extract	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	M-CSF-induced	m-csf-induced	JJ	JJ	_	26	amod	_	_
25	blood	blood	NN	NN	_	26	compound	_	_
26	monocytes	monocyte	NNS	NNS	_	22	nmod	_	_
27	but	but	CC	CC	_	22	cc	_	_
28	not	not	RB	RB	_	30	neg	_	_
29	in	in	IN	IN	_	30	case	_	_
30	monocytes	monocyte	NNS	NNS	_	22	conj	_	_
31	exposed	expose	VBN	VBN	_	30	acl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	medium	medium	NN	NN	_	34	compound	_	_
34	treatment	treatment	NN	NN	_	31	nmod	_	_
35	only	only	RB	RB	_	34	advmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	M-CSF	m-csf	NN	NN	_	6	compound	_	_
6	induction	induction	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	M-CSF	m-csf	NN	NN	_	6	nmod	_	_
9	involves	involve	VBZ	VBZ	_	3	ccomp	_	_
10	G	g	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	9	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	PKC	pkc	NN	NN	_	11	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF	nf	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	16	nsubj	_	_
4	by	by	IN	IN	_	8	case	_	_
5	tumor	tumor	NN	NN	_	8	compound	_	_
6	necrosis	necrosis	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	Jurkat	jurkat	NN	NN	_	14	compound	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	3	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	independent	independent	JJ	JJ	_	0	root	_	_
17	of	of	IN	IN	_	20	case	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	protein	protein	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	C	c	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	Ca(2+)-regulated	ca(2+)-regulated	JJ	JJ	_	28	amod	_	_
28	kinases	kinase	NNS	NNS	_	20	conj	_	_
29	.	.	.	.	_	16	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	able	able	JJ	JJ	_	7	amod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	control	control	VB	VB	_	8	xcomp	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	genes	gene	NNS	NNS	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	25	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	21	compound	_	_
21	virus	virus	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	HIV	hiv	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	genes	gene	NNS	NNS	_	16	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	upon	upon	IN	IN	_	11	case	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	treatment	treatment	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	phorbol	phorbol	NN	NN	_	14	compound	_	_
14	esters	ester	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cytokine	cytokine	NN	NN	_	14	conj	_	_
18	tumor	tumor	NN	NN	_	21	compound	_	_
19	necrosis	necrosis	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	17	dep	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	TNF	tnf	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	work	work	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	investigated	investigate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	events	event	NNS	NNS	_	7	dobj	_	_
11	leading	lead	VBG	VBG	_	10	acl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	TNF	tnf	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	15	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Jurkat	jurkat	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
30	subclone	subclone	JJ	JJ	_	31	amod	_	_
31	JCT6	jct6	NN	NN	_	24	conj	_	_
32	,	,	,	,	_	31	punct	_	_
33	which	which	WDT	WDT	_	34	nsubj	_	_
34	presents	present	VBZ	VBZ	_	31	acl:relcl	_	_
35	a	a	DT	DT	_	36	det	_	_
36	deficiency	deficiency	NN	NN	_	34	dobj	_	_
37	in	in	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	PKA	pka	NN	NN	_	41	compound	_	_
40	transduction	transduction	NN	NN	_	41	compound	_	_
41	pathway	pathway	NN	NN	_	36	nmod	_	_
42	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	in	in	IN	IN	_	7	case	_	_
5	both	both	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	16	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	phorbol	phorbol	NN	NN	_	11	compound	_	_
11	ester	ester	NN	NN	_	16	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	conj	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	able	able	JJ	JJ	_	2	ccomp	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	activate	activate	VB	VB	_	16	xcomp	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	positively	positively	RB	RB	_	5	advmod	_	_
5	modulated	modulate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	Ca2+	ca2+	NN	NN	_	8	compound	_	_
8	influx	influx	NN	NN	_	5	nmod	_	_
9	while	while	IN	IN	_	13	mark	_	_
10	TNF	tnf	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	13	nsubj	_	_
13	was	be	VBD	VBD	_	5	advcl	_	_
14	not	not	RB	RB	_	13	neg	_	_
15	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	while	while	IN	IN	_	7	mark	_	_
4	PMA	pma	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	19	advcl	_	_
8	by	by	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	PKC	pkc	NN	NN	_	12	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	12	compound	_	_
12	staurosporin	staurosporin	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	19	punct	_	_
14	the	the	DT	DT	_	17	det	_	_
15	TNF	tnf	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	effect	effect	NN	NN	_	19	nsubj	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	unchanged	unchanged	JJ	JJ	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	TNF	tnf	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	activate	activate	VB	VB	_	0	root	_	_
6	cAMP	camp	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	signal	signal	NN	NN	_	13	nsubjpass	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	modulated	modulate	VBN	VBN	_	5	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	cAMP	camp	NN	NN	_	16	compound	_	_
16	activators	activator	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	cAMP	camp	NN	NN	_	4	compound	_	_
4	activators	activator	NNS	NNS	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	activate	activate	VB	VB	_	0	root	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Jurkat	jurkat	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	TNF	tnf	NN	NN	_	4	nmod:npmod	_	_
4	alpha-induced	alpha-induced	JJ	JJ	_	7	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	9	xcomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	none	none	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	major	major	JJ	JJ	_	19	amod	_	_
18	signal-mediating	signal-mediating	JJ	JJ	_	19	amod	_	_
19	kinases	kinase	NNS	NNS	_	14	nmod	_	_
20	such	such	JJ	JJ	_	24	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	protein	protein	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	C	c	NN	NN	_	19	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PKC	pkc	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	24	punct	_	_
29	protein	protein	NN	NN	_	31	compound	_	_
30	kinase	kinase	NN	NN	_	31	compound	_	_
31	A	a	NN	NN	_	24	conj	_	_
32	,	,	,	,	_	24	punct	_	_
33	or	or	CC	CC	_	24	cc	_	_
34	Ca(2+)-regulated	ca(2+)-regulated	JJ	JJ	_	35	amod	_	_
35	kinases	kinase	NNS	NNS	_	24	conj	_	_
36	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	cytoplasmic	cytoplasmic	JJ	JJ	_	7	amod	_	_
7	acidification	acidification	NN	NN	_	8	nsubj	_	_
8	facilitated	facilitate	VBD	VBD	_	4	ccomp	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	dobj	_	_
12	by	by	IN	IN	_	15	case	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	TNF	tnf	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	PKC	pkc	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	8	punct	_	_
19	by	by	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	mechanism	mechanism	NN	NN	_	8	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	increases	increase	VBZ	VBZ	_	21	acl:relcl	_	_
24	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
25	B/I	b/i	NN	NN	_	28	compound	_	_
26	kappa	kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	dissociation	dissociation	NN	NN	_	23	dobj	_	_
29	without	without	IN	IN	_	30	mark	_	_
30	affecting	affect	VBG	VBG	_	23	advcl	_	_
31	the	the	DT	DT	_	35	det	_	_
32	NF-kappa	nf-kappa	NN	NN	_	35	compound	_	_
33	B	b	NN	NN	_	35	compound	_	_
34	translocation	translocation	NN	NN	_	35	compound	_	_
35	step	step	NN	NN	_	30	dobj	_	_
36	.	.	.	.	_	4	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	stably	stably	RB	RB	_	8	advmod	_	_
8	expressing	express	VBG	VBG	_	6	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	Tax	tax	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	18	case	_	_
13	human	human	JJ	JJ	_	18	amod	_	_
14	T	t	NN	NN	_	18	compound	_	_
15	cell	cell	NN	NN	_	18	compound	_	_
16	lymphotropic	lymphotropic	JJ	JJ	_	18	amod	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	type	type	NN	NN	_	11	nmod	_	_
19	I	i	CD	CD	_	18	nummod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	24	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
5	Tax	tax	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	interaction	interaction	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	recognition	recognition	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	on	on	IN	IN	_	22	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	nmod:npmod	_	_
20	B-dependent	b-dependent	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	9	conj	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	examined	examine	VBN	VBN	_	0	root	_	_
25	in	in	IN	IN	_	30	case	_	_
26	T	t	NN	NN	_	30	compound	_	_
27	lymphoid	lymphoid	JJ	JJ	_	30	amod	_	_
28	Jurkat	jurkat	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	24	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	19D	19d	NN	NN	_	30	dep	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	9J	9j	NN	NN	_	32	conj	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	stably	stably	RB	RB	_	37	advmod	_	_
37	transformed	transform	VBN	VBN	_	30	acl	_	_
38	with	with	IN	IN	_	42	case	_	_
39	a	a	DT	DT	_	42	det	_	_
40	Tax	tax	NN	NN	_	42	compound	_	_
41	expression	expression	NN	NN	_	42	compound	_	_
42	vector	vector	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	24	punct	_	_

1	Tax	tax	NN	NN	_	5	compound	_	_
2	expressing	expressing	NN	NN	_	5	compound	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	6	nsubj	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	level	level	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	detectable	detectable	JJ	JJ	_	14	amod	_	_
17	by	by	IN	IN	_	20	case	_	_
18	mobility	mobility	NN	NN	_	20	compound	_	_
19	shift	shift	NN	NN	_	20	compound	_	_
20	assay	assay	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	uv	uv	NN	NN	_	23	compound	_	_
23	cross-linking	cross-linking	NN	NN	_	20	conj	_	_
24	using	use	VBG	VBG	_	20	acl	_	_
25	a	a	DT	DT	_	29	det	_	_
26	palindromic	palindromic	JJ	JJ	_	29	amod	_	_
27	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	probe	probe	NN	NN	_	24	dobj	_	_
30	homologous	homologous	JJ	JJ	_	29	amod	_	_
31	to	to	TO	TO	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	interferon	interferon	NN	NN	_	36	compound	_	_
34	beta	beta	NN	NN	_	36	compound	_	_
35	PRDII	prdii	NN	NN	_	36	compound	_	_
36	site	site	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	Jurkat	jurkat	NN	NN	_	9	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NC2.10	nc2.10	NN	NN	_	2	conj	_	_
5	induction	induction	NN	NN	_	9	nsubj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	phorbol	phorbol	NN	NN	_	8	compound	_	_
8	esters	ester	NNS	NNS	_	5	nmod	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	appearance	appearance	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	new	new	JJ	JJ	_	17	amod	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	12	nmod	_	_
18	of	of	IN	IN	_	25	case	_	_
19	85	85	CD	CD	_	21	nummod	_	_
20	,	,	,	,	_	21	punct	_	_
21	75	75	CD	CD	_	25	nummod	_	_
22	,	,	,	,	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	54	54	CD	CD	_	21	conj	_	_
25	kDa	kda	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	9	punct	_	_
27	whereas	whereas	IN	IN	_	9	dep	_	_
28	in	in	IN	IN	_	31	case	_	_
29	Tax	tax	NN	NN	_	31	compound	_	_
30	expressing	expressing	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	43	nmod	_	_
32	the	the	DT	DT	_	34	det	_	_
33	85-kDa	85-kda	JJ	JJ	_	34	amod	_	_
34	protein	protein	NN	NN	_	43	nsubjpass	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	a	a	DT	DT	_	40	det	_	_
37	92-kDa	92-kda	JJ	JJ	_	40	amod	_	_
38	DNA	dna	NN	NN	_	40	compound	_	_
39	binding	binding	NN	NN	_	40	compound	_	_
40	protein	protein	NN	NN	_	34	conj	_	_
41	were	be	VBD	VBD	_	43	auxpass	_	_
42	constitutively	constitutively	RB	RB	_	43	advmod	_	_
43	induced	induce	VBN	VBN	_	9	parataxis	_	_
44	.	.	.	.	_	9	punct	_	_

1	Expression	expression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Tax	tax	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	19D	19d	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	9J	9j	NN	NN	_	6	conj	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	transcription	transcription	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	21	case	_	_
13	the	the	DT	DT	_	21	det	_	_
14	endogenous	endogenous	JJ	JJ	_	21	amod	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	nmod:npmod	_	_
16	B-dependent	b-dependent	JJ	JJ	_	21	amod	_	_
17	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	21	amod	_	_
18	colony	colony	NN	NN	_	21	compound	_	_
19	stimulating	stimulating	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	11	nmod	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	increased	increase	VBD	VBD	_	26	amod	_	_
24	basal	basal	JJ	JJ	_	26	amod	_	_
25	level	level	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	11	conj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	transfected	transfect	VBN	VBN	_	31	amod	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	nmod:npmod	_	_
30	B-regulated	b-regulated	JJ	JJ	_	31	amod	_	_
31	promoters	promoter	NNS	NNS	_	26	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Nonetheless	nonetheless	RB	RB	_	12	advmod	_	_
2	transcription	transcription	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	both	both	CC	CC	_	6	cc:preconj	_	_
5	the	the	DT	DT	_	6	det	_	_
6	endogenous	endogenous	JJ	JJ	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	6	conj	_	_
9	transfected	transfect	VBN	VBN	_	8	amod	_	_
10	gene	gene	NN	NN	_	6	dep	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	inducible	inducible	JJ	JJ	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	PMA	pma	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	Tax	tax	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	8	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	Jurkat	jurkat	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	alter	alter	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	stoichiometry	stoichiometry	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
13	B	b	NN	NN	_	16	compound	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	10	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	thus	thus	RB	RB	_	8	advmod	_	_
19	change	change	VB	VB	_	8	dep	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	nmod:npmod	_	_
24	B-regulated	b-regulated	JJ	JJ	_	25	amod	_	_
25	promoters	promoter	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	:	:	:	:	_	1	punct	_	_
10	effects	effect	NNS	NNS	_	1	dep	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	treatment	treatment	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	Cushing	cushing	NN	NN	_	17	nmod:poss	_	_
16	's	's	POS	POS	_	15	case	_	_
17	disease	disease	NN	NN	_	10	appos	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	ketoconazole	ketoconazole	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	10	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GcR	gcr	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	determined	determine	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	whole	whole	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	assay	assay	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	mononulear	mononulear	JJ	JJ	_	16	amod	_	_
16	leukocytes	leukocyte	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	hMNL	hmnl	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	from	from	IN	IN	_	22	case	_	_
21	control	control	NN	NN	_	22	compound	_	_
22	subjects	subject	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	patients	patient	NNS	NNS	_	22	conj	_	_
25	receiving	receive	VBG	VBG	_	24	acl	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	27	compound	_	_
27	therapy	therapy	NN	NN	_	25	dobj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	systemic	systemic	JJ	JJ	_	30	amod	_	_
30	diseases	disease	NNS	NNS	_	27	nmod	_	_
31	and	and	CC	CC	_	22	cc	_	_
32	Cushing	cushing	NN	NN	_	34	nmod:poss	_	_
33	's	's	POS	POS	_	32	case	_	_
34	disease	disease	NN	NN	_	35	compound	_	_
35	patients	patient	NNS	NNS	_	22	conj	_	_
36	with	with	IN	IN	_	40	nmod	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	without	without	IN	IN	_	36	conj	_	_
39	ketoconazole	ketoconazole	NN	NN	_	40	compound	_	_
40	therapy	therapy	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	7	punct	_	_

1	Prolonged	prolonged	JJ	JJ	_	3	amod	_	_
2	corticosteroid	corticosteroid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	4	nsubj	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	down-regulation	down-regulation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GcR	gcr	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	while	while	IN	IN	_	21	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	mean	mean	NN	NN	_	13	compound	_	_
13	level	level	NN	NN	_	21	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	GcR	gcr	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	Cushing	cushing	NN	NN	_	19	nmod:poss	_	_
18	's	's	POS	POS	_	17	case	_	_
19	disease	disease	NN	NN	_	13	nmod	_	_
20	was	be	VBD	VBD	_	21	cop	_	_
21	normal	normal	JJ	JJ	_	4	advcl	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	group	group	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	however	however	RB	RB	_	14	advmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	14	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	morning	morning	NN	NN	_	13	compound	_	_
11	plasma	plasma	NN	NN	_	13	compound	_	_
12	cortisol	cortisol	NN	NN	_	13	compound	_	_
13	values	value	NNS	NNS	_	8	conj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	17	det	_	_
16	negative	negative	JJ	JJ	_	17	amod	_	_
17	correlation	correlation	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	14	punct	_	_
19	indicating	indicate	VBG	VBG	_	14	advcl	_	_
20	a	a	DT	DT	_	23	det	_	_
21	subtle	subtle	JJ	JJ	_	23	amod	_	_
22	down-regulatory	down-regulatory	JJ	JJ	_	23	amod	_	_
23	effect	effect	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	GcR	gcr	NN	NN	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	unaltered	unaltered	JJ	JJ	_	0	root	_	_
6	after	after	IN	IN	_	9	mark	_	_
7	these	these	DT	DT	_	8	det	_	_
8	patients	patient	NNS	NNS	_	9	nsubj	_	_
9	received	receive	VBD	VBD	_	5	advcl	_	_
10	ketoconazole	ketoconazole	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	5	punct	_	_
12	in	in	IN	IN	_	17	case	_	_
13	spite	spite	NN	NN	_	17	dep	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	marked	marked	JJ	JJ	_	17	amod	_	_
17	reduction	reduction	NN	NN	_	5	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	morning	morning	NN	NN	_	21	compound	_	_
20	plasma	plasma	NN	NN	_	21	compound	_	_
21	cortisol	cortisol	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	urinary	urinary	JJ	JJ	_	24	amod	_	_
24	free	free	JJ	JJ	_	25	amod	_	_
25	cortisol	cortisol	NN	NN	_	21	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	ketoconazole	ketoconazole	NN	NN	_	9	nsubj	_	_
6	was	be	VBD	VBD	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	weak	weak	JJ	JJ	_	9	amod	_	_
9	competitor	competitor	NN	NN	_	3	ccomp	_	_
10	of	of	IN	IN	_	11	case	_	_
11	GcR	gcr	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	intact	intact	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	although	although	IN	IN	_	19	mark	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	significantly	significantly	RB	RB	_	19	advmod	_	_
19	inhibited	inhibit	VBD	VBD	_	9	advcl	_	_
20	-LSB-3H-RSB-	-lsb-3h-rsb-	NN	NN	_	22	compound	_	_
21	dexamethasone	dexamethasone	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	cytosolic	cytosolic	JJ	JJ	_	25	amod	_	_
25	preparations	preparation	NNS	NNS	_	19	nmod	_	_
26	from	from	IN	IN	_	28	case	_	_
27	rat	rat	NN	NN	_	28	compound	_	_
28	tissues	tissue	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	GcR	gcr	NN	NN	_	9	nsubjpass	_	_
6	in	in	IN	IN	_	7	case	_	_
7	hMNL	hmnl	NN	NN	_	5	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	down-regulated	down-regulate	VBN	VBN	_	3	ccomp	_	_
10	by	by	IN	IN	_	12	case	_	_
11	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
12	steroids	steroid	NNS	NNS	_	9	nmod	_	_
13	given	give	VBN	VBN	_	12	acl	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	but	but	CC	CC	_	9	cc	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	showed	show	VBD	VBD	_	9	conj	_	_
20	very	very	RB	RB	_	21	advmod	_	_
21	mild	mild	JJ	JJ	_	22	amod	_	_
22	down-regulation	down-regulation	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	hypercortisolemic	hypercortisolemic	JJ	JJ	_	25	amod	_	_
25	patients	patient	NNS	NNS	_	19	nmod	_	_
26	suffering	suffer	VBG	VBG	_	25	acl	_	_
27	from	from	IN	IN	_	30	case	_	_
28	Cushing	cushing	NN	NN	_	30	nmod:poss	_	_
29	's	's	POS	POS	_	28	case	_	_
30	disease	disease	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	either	either	CC	CC	_	8	cc:preconj	_	_
8	up-regulation	up-regulation	NN	NN	_	6	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	antagonism	antagonism	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	GcR	gcr	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	ketoconazole	ketoconazole	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	8	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	at	at	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	time	time	NN	NN	_	6	nmod	_	_
20	that	that	IN	IN	_	30	advmod	_	_
21	cortisol	cortisol	NN	NN	_	22	compound	_	_
22	levels	level	NNS	NNS	_	30	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	patients	patient	NNS	NNS	_	22	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	Cushing	cushing	NN	NN	_	28	nmod:poss	_	_
27	's	's	POS	POS	_	26	case	_	_
28	disease	disease	NN	NN	_	24	nmod	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	reduced	reduce	VBN	VBN	_	19	dep	_	_
31	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	beneficial	beneficial	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	18	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ketoconazole	ketoconazole	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	Cushing	cushing	NN	NN	_	12	nmod:poss	_	_
11	's	's	POS	POS	_	10	case	_	_
12	disease	disease	NN	NN	_	6	nmod	_	_
13	are	be	VBP	VBP	_	18	cop	_	_
14	due	due	JJ	JJ	_	18	case	_	_
15	to	to	TO	TO	_	18	case	_	_
16	adrenal	adrenal	JJ	JJ	_	18	amod	_	_
17	cortisol	cortisol	NN	NN	_	18	compound	_	_
18	suppression	suppression	NN	NN	_	2	ccomp	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	not	not	RB	RB	_	22	neg	_	_
21	to	to	TO	TO	_	22	case	_	_
22	interaction	interaction	NN	NN	_	18	conj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	GcR	gcr	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	target	target	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	18	punct	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	that	that	IN	IN	_	41	mark	_	_
31	the	the	DT	DT	_	32	det	_	_
32	process	process	NN	NN	_	41	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	GcR	gcr	NN	NN	_	35	compound	_	_
35	regulation	regulation	NN	NN	_	32	nmod	_	_
36	in	in	IN	IN	_	37	case	_	_
37	hMNL	hmnl	NN	NN	_	32	nmod	_	_
38	is	be	VBZ	VBZ	_	41	cop	_	_
39	a	a	DT	DT	_	41	det	_	_
40	complex	complex	JJ	JJ	_	41	amod	_	_
41	phenomenon	phenomenon	NN	NN	_	18	conj	_	_
42	awaiting	await	VBG	VBG	_	41	acl	_	_
43	further	further	RBR	RBR	_	44	advmod	_	_
44	elucidation	elucidation	NN	NN	_	42	dobj	_	_
45	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	anorexia	anorexia	NN	NN	_	7	compound	_	_
7	nervosa	nervosa	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	aim	aim	NN	NN	_	5	nsubj	_	_
5	was	be	VBD	VBD	_	1	dep	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	explore	explore	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	down-regulation	down-regulation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	9	nmod	_	_
14	during	during	IN	IN	_	15	case	_	_
15	hypercortisolaemia	hypercortisolaemia	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	anorexia	anorexia	NN	NN	_	18	compound	_	_
18	nervosa	nervosa	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	DESIGN	design	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Urine	urine	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	plasma	plasma	NN	NN	_	3	conj	_	_
6	samples	sample	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	obtained	obtain	VBN	VBN	_	1	dep	_	_
9	for	for	IN	IN	_	11	case	_	_
10	cortisol	cortisol	NN	NN	_	11	compound	_	_
11	determination	determination	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	isolated	isolate	VBN	VBN	_	8	conj	_	_
17	for	for	IN	IN	_	20	case	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	studies	study	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	PATIENTS	patient	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Sixteen	sixteen	CD	CD	_	5	nummod	_	_
4	anorexic	anorexic	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	36	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	aged	aged	JJ	JJ	_	5	amod	_	_
8	16-27	16-27	CD	CD	_	9	nummod	_	_
9	years	year	NNS	NNS	_	7	nmod:tmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	mean	mean	NN	NN	_	5	nmod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	SEM	sem	NN	NN	_	18	compound	_	_
16	body	body	NN	NN	_	18	compound	_	_
17	mass	mass	NN	NN	_	18	compound	_	_
18	index	index	NN	NN	_	13	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	14.2	14.2	CD	CD	_	13	nmod	_	_
21	+/-	+/-	CC	CC	_	20	cc	_	_
22	2.0	2.0	CD	CD	_	20	conj	_	_
23	(	(	-LRB-	-LRB-	_	13	punct	_	_
24	ranging	range	VBG	VBG	_	13	acl	_	_
25	from	from	IN	IN	_	26	case	_	_
26	11.1	11.1	CD	CD	_	24	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	17.4	17.4	CD	CD	_	26	nmod	_	_
29	)	)	-RRB-	-RRB-	_	13	punct	_	_
30	,	,	,	,	_	5	punct	_	_
31	and	and	CC	CC	_	5	cc	_	_
32	15	15	CD	CD	_	34	nummod	_	_
33	normal	normal	JJ	JJ	_	34	amod	_	_
34	women	woman	NNS	NNS	_	5	conj	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	studied	study	VBN	VBN	_	1	dep	_	_
37	.	.	.	.	_	36	punct	_	_

1	Six	six	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	reinvestigated	reinvestigate	VBN	VBN	_	0	root	_	_
5	after	after	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	significant	significant	JJ	JJ	_	9	amod	_	_
8	weight	weight	NN	NN	_	9	compound	_	_
9	gain	gain	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	MEASUREMENTS	measurement	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	binding	binding	NN	NN	_	13	nsubjpass	_	_
5	capacity	capacity	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	affinity	affinity	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	4	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	measured	measure	VBN	VBN	_	1	dep	_	_
14	with	with	IN	IN	_	15	case	_	_
15	dexamethasone	dexamethasone	NN	NN	_	13	nmod	_	_
16	as	as	IN	IN	_	17	case	_	_
17	ligand	ligand	NN	NN	_	15	nmod	_	_
18	on	on	IN	IN	_	19	case	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	both	both	DT	DT	_	7	cc:preconj	_	_
7	total	total	JJ	JJ	_	12	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	free	free	JJ	JJ	_	7	conj	_	_
10	plasma	plasma	NN	NN	_	12	compound	_	_
11	cortisol	cortisol	NN	NN	_	12	compound	_	_
12	concentrations	concentration	NNS	NNS	_	14	nsubj	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	higher	higher	JJR	JJR	_	1	dep	_	_
15	than	than	IN	IN	_	19	case	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	women	woman	NNS	NNS	_	14	advcl	_	_
20	,	,	,	,	_	14	punct	_	_
21	as	as	IN	IN	_	26	dep	_	_
22	was	be	VBD	VBD	_	26	dep	_	_
23	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
24	urinary	urinary	JJ	JJ	_	26	amod	_	_
25	free	free	JJ	JJ	_	26	amod	_	_
26	cortisol	cortisol	NN	NN	_	14	advcl	_	_
27	;	;	:	:	_	14	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	number	number	NN	NN	_	53	nsubj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	glucocorticoid	glucocorticoid	NN	NN	_	32	compound	_	_
32	receptors	receptor	NNS	NNS	_	29	nmod	_	_
33	per	per	IN	IN	_	34	case	_	_
34	cell	cell	NN	NN	_	32	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	Ro	ro	NN	NN	_	32	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	and	and	CC	CC	_	29	cc	_	_
39	the	the	DT	DT	_	41	det	_	_
40	binding	binding	NN	NN	_	41	compound	_	_
41	affinity	affinity	NN	NN	_	29	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	Kd	kd	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	for	for	IN	IN	_	46	case	_	_
46	dexamethasone	dexamethasone	NN	NN	_	41	nmod	_	_
47	were	be	VBD	VBD	_	53	cop	_	_
48	,	,	,	,	_	53	punct	_	_
49	however	however	RB	RB	_	53	advmod	_	_
50	,	,	,	,	_	53	punct	_	_
51	not	not	RB	RB	_	52	dep	_	_
52	significantly	significantly	RB	RB	_	53	advmod	_	_
53	different	different	JJ	JJ	_	1	dep	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	Ro	ro	NN	NN	_	53	dep	_	_
56	:	:	:	:	_	55	punct	_	_
57	7687	7687	CD	CD	_	64	nummod	_	_
58	+/-	+/-	CC	CC	_	57	cc	_	_
59	1750	1750	CD	CD	_	57	conj	_	_
60	vs	vs	CC	CC	_	59	cc	_	_
61	7347	7347	CD	CD	_	59	conj	_	_
62	+/-	+/-	CC	CC	_	61	cc	_	_
63	1285	1285	CD	CD	_	61	conj	_	_
64	sites/cell	sites/cell	NN	NN	_	55	dep	_	_
65	;	;	:	:	_	55	punct	_	_
66	Kd	kd	NN	NN	_	55	dep	_	_
67	:	:	:	:	_	66	punct	_	_
68	7.7	7.7	CD	CD	_	75	nummod	_	_
69	+/-	+/-	CC	CC	_	68	cc	_	_
70	2.4	2.4	CD	CD	_	68	conj	_	_
71	vs	vs	CC	CC	_	70	cc	_	_
72	7.4	7.4	CD	CD	_	70	conj	_	_
73	+/-	+/-	CC	CC	_	72	cc	_	_
74	1.7	1.7	CD	CD	_	72	conj	_	_
75	nM	nm	NN	NN	_	66	dep	_	_
76	at	at	IN	IN	_	79	case	_	_
77	24	24	CD	CD	_	79	nummod	_	_
78	degrees	degree	NNS	NNS	_	79	compound	_	_
79	C	c	NN	NN	_	75	nmod	_	_
80	)	)	-RRB-	-RRB-	_	55	punct	_	_
81	.	.	.	.	_	53	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	weight	weight	NN	NN	_	3	compound	_	_
3	gain	gain	NN	NN	_	18	nmod	_	_
4	(	(	-LRB-	-LRB-	_	12	punct	_	_
5	14	14	CD	CD	_	12	nummod	_	_
6	+/-	+/-	CC	CC	_	5	cc	_	_
7	2	2	CD	CD	_	9	nummod	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	16	16	CD	CD	_	5	conj	_	_
10	+/-	+/-	CC	CC	_	9	cc	_	_
11	2	2	CD	CD	_	9	conj	_	_
12	kg/m2	kg/m2	NN	NN	_	3	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	18	punct	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	numbers	number	NNS	NNS	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	8421	8421	CD	CD	_	0	root	_	_
19	+/-	+/-	CC	CC	_	18	cc	_	_
20	2126	2126	CD	CD	_	18	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	pre	pre	JJ	JJ	_	18	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	9011	9011	CD	CD	_	18	conj	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	500	500	CD	CD	_	25	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	post	post	JJ	JJ	_	25	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	sites/cell	sites/cell	NN	NN	_	18	dep	_	_
32	,	,	,	,	_	18	punct	_	_
33	which	which	WDT	WDT	_	37	nsubj	_	_
34	are	be	VBP	VBP	_	37	cop	_	_
35	not	not	RB	RB	_	37	neg	_	_
36	significantly	significantly	RB	RB	_	37	advmod	_	_
37	different	different	JJ	JJ	_	18	acl:relcl	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	P	p	NN	NN	_	40	dep	_	_
40	greater	greater	JJR	JJR	_	37	dep	_	_
41	than	than	IN	IN	_	42	case	_	_
42	0.2	0.2	CD	CD	_	40	nmod	_	_
43	)	)	-RRB-	-RRB-	_	40	punct	_	_
44	;	;	:	:	_	18	punct	_	_
45	the	the	DT	DT	_	46	det	_	_
46	Kd	kd	NN	NN	_	48	nsubj	_	_
47	was	be	VBD	VBD	_	48	cop	_	_
48	unchanged	unchanged	JJ	JJ	_	18	parataxis	_	_
49	(	(	-LRB-	-LRB-	_	57	punct	_	_
50	9.3	9.3	CD	CD	_	57	nummod	_	_
51	+/-	+/-	CC	CC	_	50	cc	_	_
52	2.6	2.6	CD	CD	_	50	conj	_	_
53	vs	vs	CC	CC	_	52	cc	_	_
54	9.2	9.2	CD	CD	_	52	conj	_	_
55	+/-	+/-	CC	CC	_	54	cc	_	_
56	2.4	2.4	CD	CD	_	54	conj	_	_
57	nM	nm	NN	NN	_	48	dep	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	48	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	Hypercortisolaemia	hypercortisolaemia	NN	NN	_	5	nsubj	_	_
3	does	do	VBZ	VBZ	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	down-regulate	down-regulate	VB	VB	_	1	dep	_	_
6	the	the	DT	DT	_	9	det	_	_
7	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	5	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	anorexia	anorexia	NN	NN	_	12	compound	_	_
12	nervosa	nervosa	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	post-receptor	post-receptor	JJ	JJ	_	16	amod	_	_
16	defect	defect	NN	NN	_	19	nsubjpass	_	_
17	might	might	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	involved	involve	VBN	VBN	_	5	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
22	tissue	tissue	NN	NN	_	23	compound	_	_
23	resistance	resistance	NN	NN	_	19	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	effects	effect	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	glucocorticoid	glucocorticoid	NN	NN	_	29	compound	_	_
29	hormones	hormone	NNS	NNS	_	26	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	undernutrition	undernutrition	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	Tumor	tumor	NN	NN	_	5	compound	_	_
2	necrosis	necrosis	NN	NN	_	5	compound	_	_
3	factor-alpha	factor-alpha	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	accumulation	accumulation	NN	NN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	myelomonocytic	myelomonocytic	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	motifs	motif	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	1	cc	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	stabilization	stabilization	NN	NN	_	1	conj	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytokine	cytokine	NN	NN	_	3	compound	_	_
3	TNF	tnf	NN	NN	_	4	nsubj	_	_
4	mediates	mediate	VBZ	VBZ	_	0	root	_	_
5	many	many	JJ	JJ	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	pathologic	pathologic	JJ	JJ	_	9	amod	_	_
9	signs	sign	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cachexia	cachexia	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	inflammation	inflammation	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	sepsis	sepsis	NN	NN	_	11	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	4	nsubj	_	_
4	describes	describe	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regulation	regulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TNF	tnf	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	myelomonocytic	myelomonocytic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	6	nmod	_	_
14	after	after	IN	IN	_	16	case	_	_
15	PMA	pma	NN	NN	_	16	compound	_	_
16	stimulation	stimulation	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	4	nsubj	_	_
4	exhibit	exhibit	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	low	low	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	constitutive	constitutive	JJ	JJ	_	12	amod	_	_
10	TNF	tnf	NN	NN	_	12	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Within	within	IN	IN	_	5	case	_	_
2	2	2	CD	CD	_	4	compound	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	4	4	CD	CD	_	5	nummod	_	_
5	h	h	NN	NN	_	18	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	PMA	pma	NN	NN	_	8	compound	_	_
8	exposure	exposure	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	18	punct	_	_
10	steady	steady	JJ	JJ	_	12	amod	_	_
11	state	state	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	18	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNF	tnf	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	12	nmod	_	_
16	are	be	VBP	VBP	_	18	aux	_	_
17	markedly	markedly	RB	RB	_	18	advmod	_	_
18	elevated	elevated	JJ	JJ	_	0	root	_	_
19	in	in	IN	IN	_	23	case	_	_
20	all	all	DT	DT	_	23	det	_	_
21	myelomonocytic	myelomonocytic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	18	nmod	_	_
24	studied	study	VBN	VBN	_	23	acl	_	_
25	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	rise	rise	NN	NN	_	8	nsubj	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	due	due	JJ	JJ	_	8	case	_	_
5	to	to	TO	TO	_	8	case	_	_
6	increased	increase	VBN	VBN	_	8	amod	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	stability	stability	NN	NN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	increased	increase	VBD	VBD	_	8	acl:relcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	almost	almost	RB	RB	_	14	advmod	_	_
14	twofold	twofold	RB	RB	_	11	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	to	to	TO	TO	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	overall	overall	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	8	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	20	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	rises	rise	VBZ	VBZ	_	20	acl:relcl	_	_
26	by	by	IN	IN	_	27	case	_	_
27	more	more	JJR	JJR	_	25	nmod	_	_
28	than	than	IN	IN	_	27	amod	_	_
29	sixfold	sixfold	RB	RB	_	27	advmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	level	level	NN	NN	_	16	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	genomic	genomic	JJ	JJ	_	8	amod	_	_
7	TNF	tnf	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	a	a	DT	DT	_	14	det	_	_
11	DNase	dnase	NN	NN	_	14	compound	_	_
12	I	i	CD	CD	_	14	nummod	_	_
13	hypersensitive	hypersensitive	JJ	JJ	_	14	amod	_	_
14	site	site	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	detected	detect	VBN	VBN	_	0	root	_	_
17	within	within	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TNF	tnf	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	between	between	IN	IN	_	25	case	_	_
22	-200	-200	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	-100	-100	CD	CD	_	25	nummod	_	_
25	bp	bp	NN	NN	_	20	nmod	_	_
26	relative	relative	JJ	JJ	_	31	case	_	_
27	to	to	TO	TO	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	initiation	initiation	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	16	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	Although	although	IN	IN	_	2	mark	_	_
2	absent	absent	JJ	JJ	_	14	advcl	_	_
3	in	in	IN	IN	_	7	case	_	_
4	nonexpressing	nonexpress	VBG	VBG	_	7	amod	_	_
5	erythroleukemia	erythroleukemia	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	2	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	DNase	dnase	NN	NN	_	12	compound	_	_
11	I	i	CD	CD	_	12	nummod	_	_
12	site	site	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	present	present	JJ	JJ	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	uninduced	uninduced	JJ	JJ	_	19	amod	_	_
17	myelomonocytic	myelomonocytic	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	changed	change	VBN	VBN	_	14	conj	_	_
24	after	after	IN	IN	_	26	case	_	_
25	PMA	pma	NN	NN	_	26	compound	_	_
26	induction	induction	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PMA	pma	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	c-fos	c-fos	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	correlated	correlate	VBD	VBD	_	0	root	_	_
8	well	well	RB	RB	_	7	advmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	TNF	tnf	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	7	nmod	_	_
13	;	;	:	:	_	7	punct	_	_
14	expression	expression	NN	NN	_	31	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	genes	gene	NNS	NNS	_	14	nmod	_	_
17	encoding	encode	VBG	VBG	_	16	acl	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	AP-1	ap-1	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	junB	junb	NN	NN	_	23	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	junD	jund	NN	NN	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	were	be	VBD	VBD	_	31	auxpass	_	_
30	also	also	RB	RB	_	31	advmod	_	_
31	induced	induce	VBN	VBN	_	7	parataxis	_	_
32	by	by	IN	IN	_	33	case	_	_
33	PMA	pma	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	31	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	extracts	extract	NNS	NNS	_	10	nsubj	_	_
4	from	from	IN	IN	_	9	case	_	_
5	resting	rest	VBG	VBG	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	induced	induce	VBN	VBN	_	5	conj	_	_
8	ML-1	ml-1	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	contain	contain	VBP	VBP	_	0	root	_	_
11	proteins	protein	NNS	NNS	_	10	dobj	_	_
12	binding	bind	VBG	VBG	_	11	acl	_	_
13	specifically	specifically	RB	RB	_	12	advmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	AP-1	ap-1	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	AP-2	ap-2	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	NF	nf	NN	NN	_	24	compound	_	_
22	kappa	kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	16	conj	_	_
25	located	located	JJ	JJ	_	16	amod	_	_
26	within	within	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	TNF	tnf	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	PMA	pma	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	3	nsubj	_	_
3	increases	increase	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	level	level	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	8	nmod	_	_
13	relative	relative	JJ	JJ	_	17	case	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	resting	rest	VBG	VBG	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	murine	murine	JJ	JJ	_	6	conj	_	_
9	TNF	tnf	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	3	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	discussed	discuss	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	USF-related	usf-related	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	HIV-TF1	hiv-tf1	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
12	virus-1	virus-1	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	HIV-TF1	hiv-tf1	NN	NN	_	28	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	4	acl:relcl	_	_
8	to	to	TO	TO	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	region	region	NN	NN	_	7	nmod	_	_
11	about	about	IN	IN	_	12	advmod	_	_
12	60	60	CD	CD	_	13	nummod	_	_
13	bp	bp	NN	NN	_	14	nmod:npmod	_	_
14	upstream	upstream	JJ	JJ	_	10	amod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	enhancer	enhancer	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
22	virus-1	virus-1	NN	NN	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	HIV-1	hiv-1	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	4	punct	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	purified	purify	VBN	VBN	_	0	root	_	_
29	from	from	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	28	punct	_	_

1	HIV-TF1	hiv-tf1	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	weight	weight	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	39,000	39,000	CD	CD	_	5	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Binding	binding	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HIV-TF1	hiv-tf1	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	HIV	hiv	NN	NN	_	1	nmod	_	_
7	long	long	JJ	JJ	_	9	amod	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	repeat	repeat	NN	NN	_	6	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LTR	ltr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	activated	activate	VBD	VBD	_	0	root	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HIV	hiv	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	13	advmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HIV-TF1-binding	hiv-tf1-binding	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	LTR	ltr	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	similar	similar	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	site	site	NN	NN	_	8	nmod	_	_
12	recognized	recognize	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	16	case	_	_
14	upstream	upstream	JJ	JJ	_	16	amod	_	_
15	stimulatory	stimulatory	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	USF	usf	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	adenovirus	adenovirus	NN	NN	_	25	compound	_	_
23	major	major	JJ	JJ	_	25	amod	_	_
24	late	late	JJ	JJ	_	25	amod	_	_
25	promoter	promoter	NN	NN	_	16	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	DNA-binding	dna-binding	JJ	JJ	_	2	amod	_	_
2	properties	property	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HIV-TF1	hiv-tf1	NN	NN	_	2	nmod	_	_
5	suggested	suggest	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	HIV-TF1	hiv-tf1	NN	NN	_	10	nsubj	_	_
8	might	might	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	identical	identical	JJ	JJ	_	5	ccomp	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	related	related	JJ	JJ	_	10	conj	_	_
13	to	to	TO	TO	_	14	case	_	_
14	USF	usf	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	treatment	treatment	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	purified	purify	VBN	VBN	_	6	amod	_	_
6	HIV-TF1	hiv-tf1	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	phosphatase	phosphatase	NN	NN	_	3	nmod	_	_
9	greatly	greatly	RB	RB	_	10	advmod	_	_
10	reduced	reduce	VBD	VBD	_	0	root	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	10	punct	_	_
15	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	phosphorylation	phosphorylation	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HIV-TF1	hiv-tf1	NN	NN	_	17	nmod	_	_
20	was	be	VBD	VBD	_	21	cop	_	_
21	essential	essential	JJ	JJ	_	15	ccomp	_	_
22	for	for	IN	IN	_	24	case	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	disruption	disruption	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV-TF1-binding	hiv-tf1-binding	JJ	JJ	_	5	amod	_	_
5	site	site	NN	NN	_	2	nmod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	60	60	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	6	dobj	_	_
10	decrease	decrease	NN	NN	_	9	dep	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	6	advmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	HIV-TF1	hiv-tf1	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HIV-1	hiv-1	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	toremifene	toremifene	NN	NN	_	5	compound	_	_
5	therapy	therapy	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	serum	serum	NN	NN	_	9	compound	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	2	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	breast	breast	NN	NN	_	12	compound	_	_
12	cancer	cancer	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Estrogens	estrogen	NNS	NNS	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	anti-estrogens	anti-estrogen	NNS	NNS	_	1	conj	_	_
4	enhance	enhance	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	12	dep	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	Ig	ig	NN	NN	_	12	dep	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	-secreting	-secreting	NN	NN	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	in	in	IN	IN	_	22	case	_	_
15	pokeweed	pokeweed	NN	NN	_	20	nmod:npmod	_	_
16	mitogen	mitogen	NN	NN	_	20	nmod:npmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	PWM	pwm	NN	NN	_	20	nmod:npmod	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	-stimulated	-stimulated	JJ	JJ	_	22	amod	_	_
21	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
22	cultures	culture	NNS	NNS	_	4	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	9	nsubj	_	_
2	from	from	IN	IN	_	3	case	_	_
3	patients	patient	NNS	NNS	_	1	nmod	_	_
4	who	who	WP	WP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	received	receive	VBN	VBN	_	3	acl:relcl	_	_
7	anti-estrogen	anti-estrogen	NN	NN	_	8	compound	_	_
8	therapy	therapy	NN	NN	_	6	dobj	_	_
9	show	show	VBP	VBP	_	0	root	_	_
10	similar	similar	JJ	JJ	_	11	amod	_	_
11	enhancement	enhancement	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Ig-secreting	ig-secreting	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	PWM	pwm	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	28	nmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	28	nsubjpass	_	_
6	of	of	IN	IN	_	11	case	_	_
7	anti-estrogen	anti-estrogen	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	toremifene	toremifene	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	therapy	therapy	NN	NN	_	5	nmod	_	_
12	on	on	IN	IN	_	22	case	_	_
13	serum	serum	NN	NN	_	14	compound	_	_
14	immunoglobulin	immunoglobulin	NN	NN	_	22	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IgA	iga	NN	NN	_	14	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	IgM	igm	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	IgG	igg	NN	NN	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	16	punct	_	_
22	levels	level	NNS	NNS	_	5	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	breast	breast	NN	NN	_	26	compound	_	_
25	cancer	cancer	NN	NN	_	26	compound	_	_
26	patients	patient	NNS	NNS	_	22	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	investigated	investigate	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	Serum	serum	NN	NN	_	3	compound	_	_
2	Ig	ig	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	followed	follow	VBN	VBN	_	0	root	_	_
6	up	up	RB	RB	_	8	advmod	_	_
7	to	to	TO	TO	_	8	dep	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	years	year	NNS	NNS	_	5	nmod:tmod	_	_
10	after	after	IN	IN	_	14	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	during	during	IN	IN	_	10	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	therapy	therapy	NN	NN	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	unexpected	unexpected	JJ	JJ	_	3	amod	_	_
3	finding	finding	NN	NN	_	4	nsubj	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Ig	ig	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	9	nsubj	_	_
9	decreased	decrease	VBD	VBD	_	4	ccomp	_	_
10	during	during	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	follow-up	follow-up	JJ	JJ	_	13	amod	_	_
13	period	period	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	seen	see	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	who	who	WP	WP	_	8	nsubj	_	_
8	responded	respond	VBD	VBD	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	therapy	therapy	NN	NN	_	8	nmod	_	_
12	as	as	RB	RB	_	6	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	in	in	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	6	conj	_	_
17	who	who	WP	WP	_	18	nsubj	_	_
18	did	do	VBD	VBD	_	16	acl:relcl	_	_
19	not	not	RB	RB	_	18	neg	_	_
20	.	.	.	.	_	4	punct	_	_

1	HIV1	hiv1	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	macrophages	macrophage	NNS	NNS	_	5	conj	_	_
8	promotes	promote	VBZ	VBZ	_	0	root	_	_
9	induction	induction	NN	NN	_	8	dobj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	translocation	translocation	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-KB-related	nf-kb-related	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	1991	1991	CD	CD	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	using	use	VBG	VBG	_	5	xcomp	_	_
8	electrophoretic	electrophoretic	JJ	JJ	_	11	amod	_	_
9	mobility	mobility	NN	NN	_	11	compound	_	_
10	shift	shift	NN	NN	_	11	compound	_	_
11	assays	assay	NNS	NNS	_	7	dobj	_	_
12	,	,	,	,	_	5	punct	_	_
13	that	that	IN	IN	_	34	mark	_	_
14	3	3	CD	CD	_	16	nummod	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	34	nsubjpass	_	_
17	(	(	-LRB-	-LRB-	_	16	punct	_	_
18	termed	term	VBN	VBN	_	16	acl	_	_
19	B1	b1	NN	NN	_	18	xcomp	_	_
20	,	,	,	,	_	19	punct	_	_
21	B2	b2	NN	NN	_	19	conj	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	B3	b3	NN	NN	_	19	conj	_	_
24	)	)	-RRB-	-RRB-	_	16	punct	_	_
25	with	with	IN	IN	_	26	case	_	_
26	affinity	affinity	NN	NN	_	16	nmod	_	_
27	for	for	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	KB-enhancer	kb-enhancer	JJ	JJ	_	31	amod	_	_
30	target	target	NN	NN	_	31	compound	_	_
31	sequence	sequence	NN	NN	_	26	nmod	_	_
32	were	be	VBD	VBD	_	34	auxpass	_	_
33	specifically	specifically	RB	RB	_	34	advmod	_	_
34	detected	detect	VBN	VBN	_	5	ccomp	_	_
35	in	in	IN	IN	_	37	case	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	extracts	extract	NNS	NNS	_	34	nmod	_	_
38	from	from	IN	IN	_	40	case	_	_
39	HIV1-infected	hiv1-infected	JJ	JJ	_	40	amod	_	_
40	monocytes	monocyte	NNS	NNS	_	37	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	macrophages	macrophage	NNS	NNS	_	40	conj	_	_
43	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	B2	b2	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nuclei	nucleus	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	only	only	RB	RB	_	15	advmod	_	_
13	upon	upon	IN	IN	_	15	case	_	_
14	HIV1	hiv1	NN	NN	_	15	compound	_	_
15	infection	infection	NN	NN	_	5	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	B3	b3	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	was	be	VBD	VBD	_	7	cop	_	_
5	only	only	RB	RB	_	6	advmod	_	_
6	slightly	slightly	RB	RB	_	7	advmod	_	_
7	evident	evident	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	nuclei	nucleus	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	uninfected	uninfected	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	but	but	CC	CC	_	7	cc	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	readily	readily	RB	RB	_	16	advmod	_	_
16	detectable	detectable	JJ	JJ	_	7	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	nuclei	nucleus	NNS	NNS	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	infected	infected	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	remained	remain	VBD	VBD	_	0	root	_	_
4	very	very	RB	RB	_	5	advmod	_	_
5	low	low	JJ	JJ	_	3	xcomp	_	_
6	in	in	IN	IN	_	7	case	_	_
7	nuclei	nucleus	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV1-infected	hiv1-infected	JJ	JJ	_	10	amod	_	_
10	macrophages	macrophage	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	B2	b2	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	6	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cytosol	cytosol	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	macrophages	macrophage	NNS	NNS	_	17	conj	_	_
20	as	as	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	12	nmod	_	_
24	,	,	,	,	_	12	punct	_	_
25	indicating	indicate	VBG	VBG	_	12	xcomp	_	_
26	that	that	IN	IN	_	30	mark	_	_
27	it	it	PRP	PRP	_	30	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	30	auxpass	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	associated	associate	VBN	VBN	_	25	ccomp	_	_
31	with	with	IN	IN	_	33	case	_	_
32	an	a	DT	DT	_	33	det	_	_
33	inhibitor	inhibitor	NN	NN	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	IKB	ikb	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	3	nsubj	_	_
3	remained	remain	VBD	VBD	_	0	root	_	_
4	clustered	cluster	VBN	VBN	_	3	xcomp	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cytosol	cytosol	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	translocated	translocate	VBN	VBN	_	3	conj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
14	only	only	RB	RB	_	17	advmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	HIV1	hiv1	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	B3	b3	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cytosol	cytosol	NN	NN	_	5	nmod	_	_
9	only	only	RB	RB	_	13	advmod	_	_
10	when	when	WRB	WRB	_	13	advmod	_	_
11	cells	cell	NNS	NNS	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	HIV1-infected	hiv1-infected	JJ	JJ	_	5	advcl	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV1	hiv1	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	translocation	translocation	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	factors	factor	NNS	NNS	_	8	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	discussed	discuss	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Induction	induction	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	during	during	IN	IN	_	7	case	_	_
6	monocyte	monocyte	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	1	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	HIV-gene	hiv-gene	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Cells	cell	NNS	NNS	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	5	amod	_	_
5	lineage	lineage	NN	NN	_	1	nmod	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	targets	target	NNS	NNS	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	HIV	hiv	NN	NN	_	11	compound	_	_
11	infection	infection	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	26	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	phenotypic	phenotypic	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	26	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	monocyte	monocyte	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	7	nmod	_	_
12	induced	induce	VBN	VBN	_	7	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	phorbol	phorbol	NN	NN	_	15	compound	_	_
15	esters	ester	NNS	NNS	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	tumour	tumour	NN	NN	_	20	compound	_	_
18	necrosis	necrosis	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	15	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	TNF	tnf	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	associated	associate	VBN	VBN	_	2	ccomp	_	_
27	with	with	IN	IN	_	28	case	_	_
28	expression	expression	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
31	factor	factor	NN	NN	_	33	compound	_	_
32	kappa	kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	28	nmod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	parallel	parallel	NN	NN	_	5	dep	_	_
3	with	with	IN	IN	_	5	case	_	_
4	such	such	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	22	nmod	_	_
6	,	,	,	,	_	22	punct	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	22	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	monitored	monitor	VBN	VBN	_	8	acl	_	_
11	using	use	VBG	VBG	_	10	xcomp	_	_
12	an	a	DT	DT	_	19	det	_	_
13	HIV	hiv	NN	NN	_	19	compound	_	_
14	long	long	JJ	JJ	_	19	amod	_	_
15	terminal	terminal	JJ	JJ	_	19	amod	_	_
16	repeat	repeat	NN	NN	_	19	compound	_	_
17	reporter	reporter	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	construct	construct	NN	NN	_	11	dobj	_	_
20	,	,	,	,	_	8	punct	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	activated	activate	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	such	such	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	under	under	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	influence	influence	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	enhanced	enhance	VBN	VBN	_	33	amod	_	_
31	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	22	punct	_	_

1	Also	also	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	in	in	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	promonocyte	promonocyte	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	20	nmod	_	_
8	chronically	chronically	RB	RB	_	9	advmod	_	_
9	infected	infect	VBN	VBN	_	7	amod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	HIV	hiv	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	20	punct	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	20	nsubjpass	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	HIV	hiv	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	15	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	enhanced	enhance	VBN	VBN	_	0	root	_	_
21	on	on	IN	IN	_	22	case	_	_
22	stimulation	stimulation	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	phorbol	phorbol	NN	NN	_	25	compound	_	_
25	ester	ester	NN	NN	_	22	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	TNF	tnf	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	20	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	stimulation	stimulation	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	monocyte	monocyte	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	phorbol	phorbol	NN	NN	_	10	compound	_	_
10	esters	ester	NNS	NNS	_	3	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	TNF	tnf	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	10	conj	_	_
14	induces	induce	VBZ	VBZ	_	0	root	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	differentiation	differentiation	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	activates	activate	VBZ	VBZ	_	14	conj	_	_
19	HIV	hiv	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	14	punct	_	_

1	Such	such	PDT	PDT	_	3	det:predet	_	_
2	a	a	DT	DT	_	3	det	_	_
3	process	process	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	have	have	VB	VB	_	0	root	_	_
6	fundamental	fundamental	JJ	JJ	_	7	amod	_	_
7	implications	implication	NNS	NNS	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	AIDS	aids	NN	NN	_	10	compound	_	_
10	pathogenesis	pathogenesis	NN	NN	_	5	nmod	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	5	advmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	important	important	JJ	JJ	_	5	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	disease	disease	NN	NN	_	19	compound	_	_
19	progression	progression	NN	NN	_	16	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	opportunistic	opportunistic	JJ	JJ	_	23	amod	_	_
23	infections	infection	NNS	NNS	_	20	nmod	_	_
24	directly	directly	RB	RB	_	25	advmod	_	_
25	or	or	CC	CC	_	27	advmod	_	_
26	indirectly	indirectly	RB	RB	_	25	advmod	_	_
27	involving	involve	VBG	VBG	_	23	acl	_	_
28	macrophages	macrophage	NNS	NNS	_	27	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	NF-GM2	nf-gm2	NN	NN	_	0	root	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	interacts	interact	VBZ	VBZ	_	4	acl:relcl	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GM-CSF	gm-csf	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	essential	essential	JJ	JJ	_	14	amod	_	_
16	for	for	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	induction	induction	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	responses	response	NNS	NNS	_	23	dep	_	_
21	to	to	TO	TO	_	23	case	_	_
22	T-cell	t-cell	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	15	nmod	_	_
24	:	:	:	:	_	4	punct	_	_
25	purification	purification	NN	NN	_	4	dep	_	_
26	from	from	IN	IN	_	32	case	_	_
27	human	human	JJ	JJ	_	32	amod	_	_
28	T-cell	t-cell	NN	NN	_	32	compound	_	_
29	leukemia	leukemia	NN	NN	_	32	compound	_	_
30	line	line	NN	NN	_	32	compound	_	_
31	Jurkat	jurkat	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	25	nmod	_	_
33	and	and	CC	CC	_	25	cc	_	_
34	similarity	similarity	NN	NN	_	25	conj	_	_
35	to	to	TO	TO	_	37	case	_	_
36	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
37	B	b	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	25	punct	_	_

1	Activation	activation	NN	NN	_	25	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	antigen	antigen	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	lectin	lectin	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	or	or	CC	CC	_	6	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	combination	combination	NN	NN	_	6	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	phorbol-12-myristate	phorbol-12-myristate	NN	NN	_	15	compound	_	_
15	acetate	acetate	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	calcium	calcium	NN	NN	_	21	compound	_	_
21	ionophore	ionophore	NN	NN	_	15	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	A23187	a23187	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	leads	lead	VBZ	VBZ	_	0	root	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	induction	induction	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	genes	gene	NNS	NNS	_	28	nmod	_	_
31	for	for	IN	IN	_	33	case	_	_
32	a	a	DT	DT	_	33	det	_	_
33	set	set	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	lymphokines	lymphokine	NNS	NNS	_	33	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	including	include	VBG	VBG	_	40	case	_	_
38	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	39	amod	_	_
39	colony-stimulating	colony-stimulating	JJ	JJ	_	40	amod	_	_
40	factor	factor	NN	NN	_	35	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	GM-CSF	gm-csf	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	earlier	earlier	JJR	JJR	_	5	amod	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	upstream	upstream	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	22	nsubj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	mouse	mouse	NN	NN	_	14	compound	_	_
13	GM-CSF	gm-csf	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	9	nmod	_	_
15	at	at	IN	IN	_	16	case	_	_
16	positions	position	NNS	NNS	_	9	nmod	_	_
17	between	between	IN	IN	_	18	case	_	_
18	-95	-95	CD	CD	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-73	-73	CD	CD	_	18	conj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	essential	essential	JJ	JJ	_	2	ccomp	_	_
23	for	for	IN	IN	_	25	case	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	response	response	NN	NN	_	29	dep	_	_
28	to	to	TO	TO	_	29	case	_	_
29	PMA/A23187	pma/a23187	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	6	amod	_	_
6	motifs	motif	NNS	NNS	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	GM2	gm2	NN	NN	_	6	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GC-box	gc-box	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GM2	gm2	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GGTAGTTCCC	ggtagttccc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	recognized	recognize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	an	a	DT	DT	_	13	det	_	_
11	inducible	inducible	JJ	JJ	_	13	amod	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	NF-GM2	nf-gm2	NN	NN	_	8	nmod	_	_
14	;	;	:	:	_	8	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	other	other	JJ	JJ	_	22	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CCGCCC	ccgccc	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	by	by	IN	IN	_	22	case	_	_
21	constitutive	constitutive	JJ	JJ	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	8	parataxis	_	_
23	A1	a1	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	A2	a2	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	B	b	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	GM-CSF	gm-csf	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	purified	purify	VBN	VBN	_	2	parataxis	_	_
13	the	the	DT	DT	_	16	det	_	_
14	inducible	inducible	JJ	JJ	_	16	amod	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	NF-GM2	nf-gm2	NN	NN	_	12	dobj	_	_
17	from	from	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	extract	extract	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	stimulated	stimulate	VBN	VBN	_	24	amod	_	_
23	Jurkat	jurkat	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	on	on	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	dep	_	_
27	basis	basis	NN	NN	_	31	dep	_	_
28	of	of	IN	IN	_	31	case	_	_
29	specific	specific	JJ	JJ	_	31	amod	_	_
30	DNA-binding	dna-binding	JJ	JJ	_	31	amod	_	_
31	activity	activity	NN	NN	_	12	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	NF-GM2	nf-gm2	NN	NN	_	4	nsubj	_	_
4	consists	consist	VBZ	VBZ	_	0	root	_	_
5	of	of	IN	IN	_	16	case	_	_
6	50	50	CD	CD	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	p50	p50	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	65	65	CD	CD	_	6	conj	_	_
12	kDa	kda	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	p65	p65	NN	NN	_	16	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	polypeptides	polypeptide	NNS	NNS	_	4	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	has	have	VBZ	VBZ	_	4	conj	_	_
19	a	a	DT	DT	_	21	det	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	18	dobj	_	_
22	specific	specific	JJ	JJ	_	21	amod	_	_
23	for	for	IN	IN	_	33	case	_	_
24	both	both	CC	CC	_	33	cc:preconj	_	_
25	the	the	DT	DT	_	33	det	_	_
26	GM-CSF	gm-csf	NN	NN	_	33	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	immunoglobulin	immunoglobulin	NN	NN	_	29	compound	_	_
29	kappa	kappa	NN	NN	_	26	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	GGAAAGTCCC	ggaaagtccc	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	enhancers	enhancer	NNS	NNS	_	22	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Electrophoretically	electrophoretically	RB	RB	_	2	advmod	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	p50	p50	NN	NN	_	6	nsubj	_	_
4	alone	alone	RB	RB	_	3	advmod	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	form	form	VB	VB	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	protein-DNA	protein-dna	JJ	JJ	_	9	amod	_	_
9	complex	complex	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	but	but	CC	CC	_	6	cc	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	mixture	mixture	NN	NN	_	17	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	p50	p50	NN	NN	_	17	nsubj	_	_
17	associates	associate	VBZ	VBZ	_	6	conj	_	_
18	preferentially	preferentially	RB	RB	_	17	advmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	p65	p65	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	form	form	VB	VB	_	17	xcomp	_	_
23	the	the	DT	DT	_	25	det	_	_
24	NF-GM2	nf-gm2	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	p65	p65	NN	NN	_	5	nsubj	_	_
5	gave	give	VBD	VBD	_	0	root	_	_
6	per	per	FW	FW	_	7	compound	_	_
7	se	se	FW	FW	_	5	advmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	with	with	IN	IN	_	11	case	_	_
10	low	low	JJ	JJ	_	11	amod	_	_
11	affinity	affinity	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	a	a	DT	DT	_	15	det	_	_
14	protein-DNA	protein-dna	JJ	JJ	_	15	amod	_	_
15	complex	complex	NN	NN	_	5	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	migrated	migrate	VBD	VBD	_	15	acl:relcl	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	slowly	slowly	RB	RB	_	17	advmod	_	_
20	than	than	IN	IN	_	23	case	_	_
21	native	native	JJ	JJ	_	23	amod	_	_
22	NF-GM2	nf-gm2	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	antiserum	antiserum	NN	NN	_	16	nsubj	_	_
5	against	against	IN	IN	_	6	case	_	_
6	KBF1	kbf1	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	identical	identical	JJ	JJ	_	6	dep	_	_
9	to	to	TO	TO	_	14	case	_	_
10	50	50	CD	CD	_	14	nummod	_	_
11	kDa	kda	NN	NN	_	14	compound	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	nmod	_	_
15	)	)	-RRB-	-RRB-	_	8	punct	_	_
16	reacted	react	VBD	VBD	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	p50	p50	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF-GM2	nf-gm2	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	indicating	indicate	VBG	VBG	_	16	xcomp	_	_
24	that	that	IN	IN	_	32	mark	_	_
25	the	the	DT	DT	_	27	det	_	_
26	NF-GM2	nf-gm2	NN	NN	_	27	compound	_	_
27	polypeptide	polypeptide	NN	NN	_	32	nsubjpass	_	_
28	can	can	MD	MD	_	32	aux	_	_
29	not	not	RB	RB	_	32	neg	_	_
30	be	be	VB	VB	_	32	auxpass	_	_
31	immunologically	immunologically	RB	RB	_	32	advmod	_	_
32	differentiated	differentiate	VBN	VBN	_	23	ccomp	_	_
33	from	from	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	50	50	CD	CD	_	37	nummod	_	_
36	kDa	kda	NN	NN	_	37	compound	_	_
37	subunit	subunit	NN	NN	_	32	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	NF-GM2	nf-gm2	NN	NN	_	4	nsubj	_	_
4	activated	activate	VBD	VBD	_	0	root	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	vitro	vitro	FW	FW	_	5	dep	_	_
7	transcription	transcription	NN	NN	_	4	dobj	_	_
8	from	from	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	while	while	IN	IN	_	16	mark	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	failed	fail	VBD	VBD	_	4	advcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	stimulate	stimulate	VB	VB	_	16	xcomp	_	_
19	transcription	transcription	NN	NN	_	18	dobj	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	GM-CSF	gm-csf	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	harboring	harbor	VBG	VBG	_	23	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	GM2	gm2	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GM-CSF	gm-csf	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	through	through	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GM2/GC-box	gm2/gc-box	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	6	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	different	different	JJ	JJ	_	2	ccomp	_	_
17	from	from	IN	IN	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	carrying	carry	VBG	VBG	_	20	acl	_	_
22	the	the	DT	DT	_	25	det	_	_
23	kappa	kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	enhancer	enhancer	NN	NN	_	21	dobj	_	_
26	alone	alone	RB	RB	_	25	advmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	normal	normal	JJ	JJ	_	5	amod	_	_
5	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	effects	effect	NNS	NNS	_	2	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	age	age	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	gender	gender	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	season	season	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	plasma	plasma	NN	NN	_	18	compound	_	_
17	cortisol	cortisol	NN	NN	_	18	compound	_	_
18	concentrations	concentration	NNS	NNS	_	9	conj	_	_
19	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	2	dobj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GR	gr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MNL	mnl	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	isolated	isolate	VBN	VBN	_	10	acl	_	_
15	from	from	IN	IN	_	17	case	_	_
16	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
17	blood	blood	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	145	145	CD	CD	_	22	nummod	_	_
20	apparently	apparently	RB	RB	_	21	advmod	_	_
21	healthy	healthy	JJ	JJ	_	22	amod	_	_
22	volunteers	volunteer	NNS	NNS	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	86	86	CD	CD	_	25	nummod	_	_
25	men	man	NNS	NNS	_	22	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	59	59	CD	CD	_	28	nummod	_	_
28	women	woman	NNS	NNS	_	25	conj	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	age-related	age-related	JJ	JJ	_	3	amod	_	_
3	decrease	decrease	NN	NN	_	10	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GR	gr	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	suggested	suggest	VBN	VBN	_	0	root	_	_
11	between	between	IN	IN	_	12	case	_	_
12	subjects	subject	NNS	NNS	_	10	nmod	_	_
13	younger	younger	JJR	JJR	_	12	amod	_	_
14	than	than	IN	IN	_	16	case	_	_
15	20	20	CD	CD	_	16	nummod	_	_
16	years	year	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	elderly	elderly	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	12	conj	_	_
20	;	;	:	:	_	10	punct	_	_
21	there	there	EX	EX	_	22	expl	_	_
22	was	be	VBD	VBD	_	10	parataxis	_	_
23	no	no	DT	DT	_	26	neg	_	_
24	apparent	apparent	JJ	JJ	_	26	amod	_	_
25	seasonal	seasonal	JJ	JJ	_	26	amod	_	_
26	variation	variation	NN	NN	_	22	nsubj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	GR	gr	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	22	punct	_	_

1	Gender	gender	NN	NN	_	2	compound	_	_
2	difference	difference	NN	NN	_	10	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GR	gr	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	significant	significant	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	although	although	IN	IN	_	14	mark	_	_
13	women	woman	NNS	NNS	_	14	nsubj	_	_
14	showed	show	VBD	VBD	_	10	advcl	_	_
15	slightly	slightly	RB	RB	_	16	advmod	_	_
16	fewer	fewer	JJR	JJR	_	17	amod	_	_
17	GR	gr	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	10	punct	_	_

1	Eight	eight	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	6	nsubjpass	_	_
3	with	with	IN	IN	_	4	case	_	_
4	dermatomyositis/polymyositis	dermatomyositis/polymyositis	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	examined	examine	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	18	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	18	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	GR	gr	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	MNL	mnl	NN	NN	_	13	nmod	_	_
16	could	could	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	down-regulated	down-regulate	VBN	VBN	_	8	ccomp	_	_
19	by	by	IN	IN	_	22	case	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	cognate	cognate	JJ	JJ	_	22	amod	_	_
22	ligands	ligand	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GR	gr	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	MNL	mnl	NN	NN	_	4	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	decreased	decrease	VBN	VBN	_	0	root	_	_
13	one	one	CD	CD	_	14	nummod	_	_
14	month	month	NN	NN	_	12	nmod	_	_
15	after	after	IN	IN	_	14	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	initiation	initiation	NN	NN	_	14	dep	_	_
18	of	of	IN	IN	_	20	case	_	_
19	prednisolone	prednisolone	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	normal	normal	JJ	JJ	_	5	amod	_	_
5	subjects	subject	NNS	NNS	_	13	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	GR	gr	NN	NN	_	13	nsubj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	MNL	mnl	NN	NN	_	8	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	demonstrate	demonstrate	VB	VB	_	0	root	_	_
14	circadian	circadian	JJ	JJ	_	15	amod	_	_
15	variation	variation	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	13	punct	_	_
17	in	in	IN	IN	_	20	case	_	_
18	contrast	contrast	NN	NN	_	20	dep	_	_
19	to	to	TO	TO	_	20	case	_	_
20	concentrations	concentration	NNS	NNS	_	13	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	plasma	plasma	NN	NN	_	23	compound	_	_
23	cortisol	cortisol	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	be	be	VB	VB	_	0	root	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	be	be	VB	VB	_	2	conj	_	_
7	a	a	DT	DT	_	8	det	_	_
8	responder	responder	NN	NN	_	2	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	responses	response	NNS	NNS	_	8	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	ubiquitous	ubiquitous	JJ	JJ	_	14	amod	_	_
14	oligopeptides	oligopeptide	NNS	NNS	_	2	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	all	all	DT	DT	_	17	det	_	_
17	proteins	protein	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Amino	amino	NN	NN	_	3	compound	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	sequences	sequence	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	all	all	DT	DT	_	6	det	_	_
6	proteins	protein	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	essays	essay	NNS	NNS	_	0	root	_	_
9	written	write	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	same	same	JJ	JJ	_	13	amod	_	_
13	language	language	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Accordingly	accordingly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	same	same	JJ	JJ	_	5	amod	_	_
5	set	set	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	words	word	NNS	NNS	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	phrases	phrase	NNS	NNS	_	7	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	oligopeptides	oligopeptide	NNS	NNS	_	7	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	appear	appear	VBP	VBP	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	totally	totally	RB	RB	_	16	advmod	_	_
16	unrelated	unrelated	JJ	JJ	_	17	amod	_	_
17	proteins	protein	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reason	reason	NN	NN	_	27	nsubjpass	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	only	only	RB	RB	_	6	advmod	_	_
5	certain	certain	JJ	JJ	_	6	amod	_	_
6	individuals	individual	NNS	NNS	_	17	nsubj	_	_
7	of	of	IN	IN	_	15	case	_	_
8	particular	particular	JJ	JJ	_	15	amod	_	_
9	major	major	JJ	JJ	_	15	amod	_	_
10	histocompatibility	histocompatibility	NN	NN	_	15	compound	_	_
11	complex	complex	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	MHC	mhc	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	haplotypes	haplotype	NNS	NNS	_	6	nmod	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	mount	mount	VB	VB	_	2	ccomp	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	responses	response	NNS	NNS	_	17	dobj	_	_
20	against	against	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	given	given	JJ	JJ	_	23	amod	_	_
23	antigen	antigen	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	pathogens	pathogen	NNS	NNS	_	23	nmod	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	found	find	VBN	VBN	_	0	root	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	fact	fact	NN	NN	_	27	nmod	_	_
31	that	that	IN	IN	_	35	mark	_	_
32	T-cell	t-cell	NN	NN	_	33	compound	_	_
33	receptors	receptor	NNS	NNS	_	35	nsubjpass	_	_
34	are	be	VBP	VBP	_	35	auxpass	_	_
35	designed	design	VBN	VBN	_	30	ccomp	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	recognize	recognize	VB	VB	_	35	xcomp	_	_
38	18-20	18-20	CD	CD	_	41	nummod	_	_
39	residue-long	residue-long	JJ	JJ	_	41	amod	_	_
40	peptide	peptide	NN	NN	_	41	compound	_	_
41	fragments	fragment	NNS	NNS	_	37	dobj	_	_
42	sandwiched	sandwiched	JJ	JJ	_	41	amod	_	_
43	between	between	IN	IN	_	45	case	_	_
44	two	two	CD	CD	_	45	nummod	_	_
45	alpha-helices	alpha-helix	NNS	NNS	_	42	nmod	_	_
46	of	of	IN	IN	_	47	case	_	_
47	class	class	NN	NN	_	45	nmod	_	_
48	I	i	CD	CD	_	47	nummod	_	_
49	or	or	CC	CC	_	47	cc	_	_
50	class	class	NN	NN	_	47	conj	_	_
51	II	ii	CD	CD	_	50	nummod	_	_
52	MHC	mhc	NN	NN	_	53	compound	_	_
53	molecules	molecule	NNS	NNS	_	47	dep	_	_
54	.	.	.	.	_	27	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	range	range	NN	NN	_	10	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	peptide	peptide	NN	NN	_	6	compound	_	_
6	lengths	length	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	most	most	JJS	JJS	_	10	nsubj	_	_
9	would	would	MD	MD	_	10	aux	_	_
10	appear	appear	VB	VB	_	0	root	_	_
11	as	as	IN	IN	_	12	case	_	_
12	self	self	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	while	while	IN	IN	_	20	mark	_	_
15	nonselfness	nonselfness	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	remainders	remainder	NNS	NNS	_	15	nmod	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	destined	destine	VBN	VBN	_	10	advcl	_	_
21	to	to	TO	TO	_	24	mark	_	_
22	be	be	VB	VB	_	24	cop	_	_
23	quite	quite	RB	RB	_	24	advmod	_	_
24	ambiguous	ambiguous	JJ	JJ	_	20	xcomp	_	_
25	,	,	,	,	_	10	punct	_	_
26	hence	hence	RB	RB	_	27	advmod	_	_
27	creating	create	VBG	VBG	_	10	xcomp	_	_
28	responders	responder	NNS	NNS	_	27	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	nonresponders	nonresponder	NNS	NNS	_	28	conj	_	_
31	.	.	.	.	_	10	punct	_	_

1	Anti-CD2	anti-cd2	JJ	JJ	_	3	amod	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	antibodies	antibody	NNS	NNS	_	4	nsubj	_	_
4	activate	activate	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	9	det	_	_
6	HIV	hiv	NN	NN	_	9	compound	_	_
7	long	long	JJ	JJ	_	9	amod	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	repeat	repeat	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	CD2	cd2	NN	NN	_	7	compound	_	_
3	T	t	NN	NN	_	7	compound	_	_
4	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
5	glycoprotein	glycoprotein	NN	NN	_	7	compound	_	_
6	surface	surface	NN	NN	_	7	compound	_	_
7	molecule	molecule	NN	NN	_	8	nsubj	_	_
8	mediates	mediate	VBZ	VBZ	_	0	root	_	_
9	both	both	CC	CC	_	13	cc:preconj	_	_
10	cell	cell	NN	NN	_	13	compound	_	_
11	to	to	TO	TO	_	13	dep	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	adhesion	adhesion	NN	NN	_	8	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	two	two	CD	CD	_	20	nummod	_	_
20	processes	process	NNS	NNS	_	13	appos	_	_
21	that	that	WDT	WDT	_	23	nsubjpass	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	involved	involve	VBN	VBN	_	20	acl:relcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	spread	spread	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	HIV	hiv	NN	NN	_	29	compound	_	_
29	infection	infection	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	chronically	chronically	RB	RB	_	4	advmod	_	_
4	HIV-infected	hiv-infected	JJ	JJ	_	5	amod	_	_
5	PBMC	pbmc	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	anti-CD2	anti-cd2	JJ	JJ	_	8	amod	_	_
8	mAb	mab	NN	NN	_	1	nmod	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	infectious	infectious	JJ	JJ	_	18	amod	_	_
18	virus	virus	NN	NN	_	15	nmod	_	_
19	from	from	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cultures	culture	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanisms	mechanism	NNS	NNS	_	5	dobj	_	_
8	whereby	whereby	WRB	WRB	_	11	advmod	_	_
9	anti-CD2	anti-cd2	JJ	JJ	_	10	amod	_	_
10	antibodies	antibody	NNS	NNS	_	11	nsubj	_	_
11	stimulate	stimulate	VBP	VBP	_	7	acl:relcl	_	_
12	viral	viral	JJ	JJ	_	13	amod	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	treatment	treatment	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	transiently	transiently	RB	RB	_	7	advmod	_	_
7	transfected	transfect	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	anti-CD2	anti-cd2	JJ	JJ	_	12	amod	_	_
12	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
13	results	result	VBZ	VBZ	_	2	ccomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	activation	activation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	HIV	hiv	NN	NN	_	21	compound	_	_
19	long	long	JJ	JJ	_	21	amod	_	_
20	terminal	terminal	JJ	JJ	_	21	amod	_	_
21	repeat	repeat	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	CAT	cat	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	16	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	mutated	mutate	VBN	VBN	_	11	amod	_	_
7	HIV	hiv	NN	NN	_	11	compound	_	_
8	long	long	JJ	JJ	_	10	amod	_	_
9	terminal	terminal	JJ	JJ	_	10	amod	_	_
10	repeat-CAT	repeat-cat	NN	NN	_	11	amod	_	_
11	constructs	construct	NNS	NNS	_	5	dobj	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	gel	gel	NN	NN	_	15	compound	_	_
14	shift	shift	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	4	conj	_	_
16	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	this	this	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	dependent	dependent	JJ	JJ	_	16	ccomp	_	_
22	on	on	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	enhancer	enhancer	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	interaction	interaction	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CD2	cd2	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	natural	natural	JJ	JJ	_	11	amod	_	_
11	ligand	ligand	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	LFA-3	lfa-3	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	play	play	VB	VB	_	3	ccomp	_	_
17	a	a	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	regulation	regulation	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	0	root	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	bind	bind	VBP	VBP	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	7	case	_	_
7	elements	element	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	2	compound	_	_
2	requirements	requirement	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	primary	primary	JJ	JJ	_	7	amod	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Prior	prior	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	4	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	contribute	contribute	VBP	VBP	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	stimulated	stimulate	VBN	VBN	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	11	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	Jurkat	jurkat	NN	NN	_	21	appos	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sites	site	NNS	NNS	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
5	corresponding	corresponding	JJ	JJ	_	8	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	2	conj	_	_
9	include	include	VBP	VBP	_	0	root	_	_
10	:	:	:	:	_	9	punct	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	AP-1	ap-1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	AP-3	ap-3	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	OCT-1	oct-1	NN	NN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	NF-AT	nf-at	NN	NN	_	12	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	latter	latter	JJ	JJ	_	5	amod	_	_
3	``	``	``	``	_	5	punct	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	11	nsubj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	likely	likely	RB	RB	_	11	advmod	_	_
11	contributes	contribute	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	tissue	tissue	NN	NN	_	15	compound	_	_
15	specificity	specificity	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	IL-2	il-2	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Using	use	VBG	VBG	_	9	advcl	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	9	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	studied	study	VBN	VBN	_	0	root	_	_
10	these	these	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	primary	primary	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	blood	blood	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	verify	verify	VB	VB	_	9	dep	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	presence	presence	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	physiologic	physiologic	JJ	JJ	_	27	amod	_	_
27	setting	setting	NN	NN	_	23	nmod	_	_
28	and	and	CC	CC	_	21	cc	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	identify	identify	VB	VB	_	21	conj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	signals	signal	NNS	NNS	_	30	dobj	_	_
33	that	that	WDT	WDT	_	34	nsubj	_	_
34	stimulate	stimulate	VBP	VBP	_	32	acl:relcl	_	_
35	factor	factor	NN	NN	_	36	compound	_	_
36	activity	activity	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	9	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	factors	factor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	induced	induce	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	nuclei	nucleus	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	upon	upon	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	4	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	mitogens	mitogen	NNS	NNS	_	12	nmod	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	21	neg	_	_
17	with	with	IN	IN	_	21	case	_	_
18	exogenous	exogenous	JJ	JJ	_	21	amod	_	_
19	IL-2	il-2	NN	NN	_	21	compound	_	_
20	growth	growth	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	14	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	requirements	requirement	NNS	NNS	_	12	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	sensitivity	sensitivity	NN	NN	_	5	conj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	synthesis	synthesis	NN	NN	_	11	compound	_	_
11	inhibitors	inhibitor	NNS	NNS	_	7	nmod	_	_
12	differ	differ	VBP	VBP	_	0	root	_	_
13	considerably	considerably	RB	RB	_	12	advmod	_	_
14	.	.	.	.	_	12	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	activities	activity	NNS	NNS	_	9	nsubj	_	_
4	for	for	IN	IN	_	8	case	_	_
5	NF-AT	nf-at	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	AP-1	ap-1	NN	NN	_	5	conj	_	_
8	sites	site	NNS	NNS	_	3	nmod	_	_
9	require	require	VBP	VBP	_	0	root	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	signals	signal	NNS	NNS	_	9	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	optimal	optimal	JJ	JJ	_	14	amod	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	i.e.	i.e.	FW	FW	_	18	acl	_	_
17	,	,	,	,	_	18	punct	_	_
18	PMA	pma	NN	NN	_	11	dep	_	_
19	plus	plus	CC	CC	_	18	cc	_	_
20	either	either	CC	CC	_	21	cc:preconj	_	_
21	lectin	lectin	NN	NN	_	18	conj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	antibody	antibody	NN	NN	_	21	conj	_	_
24	to	to	TO	TO	_	30	case	_	_
25	the	the	DT	DT	_	30	det	_	_
26	CD3	cd3	NN	NN	_	30	compound	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	CD28	cd28	NN	NN	_	26	conj	_	_
29	surface	surface	NN	NN	_	30	compound	_	_
30	molecules	molecule	NNS	NNS	_	23	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	induced	induce	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	lectin	lectin	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	antibody	antibody	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and/or	and/or	CC	CC	_	6	cc	_	_
11	PMA	pma	NN	NN	_	6	conj	_	_
12	alone	alone	RB	RB	_	11	advmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	appropriate	appropriate	JJ	JJ	_	3	amod	_	_
3	stimulation	stimulation	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	NF-AT	nf-at	NN	NN	_	11	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1	ap-1	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	peculiarly	peculiarly	RB	RB	_	11	advmod	_	_
11	sensitive	sensitive	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	protein	protein	NN	NN	_	17	compound	_	_
15	synthesis	synthesis	NN	NN	_	17	compound	_	_
16	inhibitor	inhibitor	NN	NN	_	17	compound	_	_
17	anisomycin	anisomycin	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	correlate	correlate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-AT	nf-at	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	AP-1	ap-1	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	gel	gel	NN	NN	_	13	compound	_	_
12	shift	shift	NN	NN	_	13	compound	_	_
13	assays	assay	NNS	NNS	_	5	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	signals	signal	NNS	NNS	_	18	compound	_	_
18	requirements	requirement	NNS	NNS	_	3	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	IL-2	il-2	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	erythroid	erythroid	JJ	JJ	_	3	amod	_	_
3	specific	specific	JJ	JJ	_	4	amod	_	_
4	enhancer	enhancer	NN	NN	_	0	root	_	_
5	upstream	upstream	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	gene	gene	NN	NN	_	5	nmod	_	_
9	encoding	encode	VBG	VBG	_	8	acl	_	_
10	the	the	DT	DT	_	15	det	_	_
11	cell-type	cell-type	JJ	JJ	_	12	amod	_	_
12	specific	specific	JJ	JJ	_	15	amod	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	GATA-1	gata-1	NN	NN	_	9	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	GATA-1	gata-1	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	subset	subset	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	hemopoietic	hemopoietic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	where	where	WRB	WRB	_	16	advmod	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	mediates	mediate	VBZ	VBZ	_	9	acl:relcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	cell-type	cell-type	JJ	JJ	_	19	amod	_	_
19	specific	specific	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	several	several	JJ	JJ	_	23	amod	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	9	det	_	_
5	mouse	mouse	NN	NN	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	human	human	JJ	JJ	_	5	conj	_	_
8	GATA-1	gata-1	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	3	dobj	_	_
10	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	17	nsubj	_	_
3	upstream	upstream	JJ	JJ	_	2	acl:relcl	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	exon	exon	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	highly	highly	RB	RB	_	11	advmod	_	_
11	conserved	conserve	VBN	VBN	_	3	conj	_	_
12	between	between	IN	IN	_	13	case	_	_
13	mouse	mouse	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	man	man	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	3	punct	_	_
17	acts	act	VBZ	VBZ	_	0	root	_	_
18	as	as	IN	IN	_	22	case	_	_
19	an	a	DT	DT	_	22	det	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	enhancer	enhancer	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	transient	transient	JJ	JJ	_	25	amod	_	_
25	assays	assay	NNS	NNS	_	17	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	if	if	IN	IN	_	28	mark	_	_
28	linked	link	VBN	VBN	_	17	advcl	_	_
29	to	to	TO	TO	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	GATA-1	gata-1	NN	NN	_	36	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	to	to	TO	TO	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	SV40	sv40	NN	NN	_	31	conj	_	_
36	promoter	promoter	NN	NN	_	28	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	enhancer	enhancer	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	almost	almost	RB	RB	_	8	advmod	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	dependent	dependent	JJ	JJ	_	0	root	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	integrity	integrity	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	dimeric	dimeric	JJ	JJ	_	18	amod	_	_
16	GATA-1	gata-1	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Demonstration	demonstration	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	5	nmod:npmod	_	_
5	D3-responsive	d3-responsive	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	:	:	:	:	_	1	punct	_	_
11	immunologic	immunologic	JJ	JJ	_	12	amod	_	_
12	crossreactivity	crossreactivity	NN	NN	_	1	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	inverse	inverse	JJ	JJ	_	15	amod	_	_
15	regulation	regulation	NN	NN	_	12	conj	_	_
16	with	with	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	vitamin	vitamin	NN	NN	_	20	compound	_	_
19	D	d	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Using	use	VBG	VBG	_	25	advcl	_	_
2	Western	western	NN	NN	_	4	compound	_	_
3	blot	blot	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	1	dobj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	monoclonal	monoclonal	JJ	JJ	_	8	amod	_	_
8	antibody	antibody	NN	NN	_	4	nmod	_	_
9	recognizing	recognize	VBG	VBG	_	8	acl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	17-amino	17-amino	NN	NN	_	13	compound	_	_
12	acid	acid	NN	NN	_	13	compound	_	_
13	epitope	epitope	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	17	compound	_	_
17	D3	d3	NN	NN	_	21	compound	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	19	punct	_	_
19	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	17	appos	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	19	punct	_	_
21	receptor	receptor	NN	NN	_	13	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	we	we	PRP	PRP	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	detected	detect	VBN	VBN	_	0	root	_	_
26	two	two	CD	CD	_	28	nummod	_	_
27	crossreacting	crossreact	VBG	VBG	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	25	dobj	_	_
29	in	in	IN	IN	_	33	case	_	_
30	activated	activate	VBN	VBN	_	33	amod	_	_
31	normal	normal	JJ	JJ	_	33	amod	_	_
32	human	human	JJ	JJ	_	33	amod	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	smaller	smaller	JJR	JJR	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	two	two	CD	CD	_	6	nummod	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	50	50	CD	CD	_	9	nummod	_	_
9	kDa	kda	NN	NN	_	2	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
13	from	from	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	classical	classical	JJ	JJ	_	17	amod	_	_
16	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	,	,	,	,	_	12	punct	_	_
20	similar	similar	JJ	JJ	_	28	xcomp	_	_
21	to	to	TO	TO	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	classical	classical	JJ	JJ	_	25	amod	_	_
24	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	upregulated	upregulate	VBN	VBN	_	12	dep	_	_
29	in	in	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	dose-dependent	dose-dependent	JJ	JJ	_	32	amod	_	_
32	fashion	fashion	NN	NN	_	28	nmod	_	_
33	by	by	IN	IN	_	34	case	_	_
34	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	larger	larger	JJR	JJR	_	4	amod	_	_
3	crossreacting	crossreact	VBG	VBG	_	4	amod	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	an	a	DT	DT	_	8	det	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
8	mobility	mobility	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	80	80	CD	CD	_	11	nummod	_	_
11	kDa	kda	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	was	be	VBD	VBD	_	14	aux	_	_
14	localized	localized	JJ	JJ	_	5	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	cytosol	cytosol	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	and	and	CC	CC	_	5	cc	_	_
21	appeared	appear	VBD	VBD	_	5	conj	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	specific	specific	JJ	JJ	_	21	xcomp	_	_
25	for	for	IN	IN	_	27	case	_	_
26	activated	activate	VBN	VBN	_	27	amod	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
28	since	since	IN	IN	_	32	mark	_	_
29	it	it	PRP	PRP	_	32	nsubjpass	_	_
30	was	be	VBD	VBD	_	32	auxpass	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	detected	detect	VBN	VBN	_	24	advcl	_	_
33	in	in	IN	IN	_	37	case	_	_
34	several	several	JJ	JJ	_	37	amod	_	_
35	other	other	JJ	JJ	_	37	amod	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	including	include	VBG	VBG	_	39	case	_	_
39	monocytes	monocyte	NNS	NNS	_	37	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	More	more	RBR	RBR	_	2	advmod	_	_
2	strikingly	strikingly	RB	RB	_	8	advmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	80-kDa	80-kda	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	downregulated	downregulate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	dose-dependent	dose-dependent	JJ	JJ	_	12	amod	_	_
12	fashion	fashion	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	nmod	_	_
15	;	;	:	:	_	8	punct	_	_
16	this	this	DT	DT	_	17	det	_	_
17	effect	effect	NN	NN	_	19	nsubj	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	independent	independent	JJ	JJ	_	8	parataxis	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	mode	mode	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	lymphocyte	lymphocyte	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	specific	specific	JJ	JJ	_	19	conj	_	_
28	for	for	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	31	compound	_	_
31	metabolite	metabolite	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	vitamin	vitamin	NN	NN	_	34	compound	_	_
34	D3	d3	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	19	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	two	two	CD	CD	_	6	nummod	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	immunosuppressive	immunosuppressive	JJ	JJ	_	6	amod	_	_
6	agents	agent	NNS	NNS	_	14	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	6	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	cyclosporin	cyclosporin	NN	NN	_	8	conj	_	_
11	A	a	DT	DT	_	10	dep	_	_
12	,	,	,	,	_	6	punct	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	inhibited	inhibit	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	80-kDa	80-kda	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	14	punct	_	_

1	T-helper-cell	t-helper-cell	JJ	JJ	_	2	amod	_	_
2	determinants	determinant	NNS	NNS	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	antigens	antigen	NNS	NNS	_	2	nmod	_	_
6	are	be	VBP	VBP	_	0	root	_	_
7	preferentially	preferentially	RB	RB	_	8	advmod	_	_
8	located	located	JJ	JJ	_	6	advmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	cysteine-rich	cysteine-rich	JJ	JJ	_	12	amod	_	_
11	antigen	antigen	NN	NN	_	12	compound	_	_
12	segments	segment	NNS	NNS	_	8	nmod	_	_
13	resistant	resistant	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	proteolytic	proteolytic	JJ	JJ	_	16	amod	_	_
16	cleavage	cleavage	NN	NN	_	13	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	cathepsin	cathepsin	NN	NN	_	16	nmod	_	_
19	B	b	NN	NN	_	18	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	L	l	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	D	d	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	on	on	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	computer	computer	NN	NN	_	6	compound	_	_
6	algorithm	algorithm	NN	NN	_	2	nmod	_	_
7	capable	capable	JJ	JJ	_	6	amod	_	_
8	of	of	IN	IN	_	9	mark	_	_
9	predicting	predict	VBG	VBG	_	7	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	location	location	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	T-helper-cell	t-helper-cell	NN	NN	_	14	compound	_	_
14	epitopes	epitope	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	protein	protein	NN	NN	_	11	nmod	_	_
17	antigen	antigen	NN	NN	_	16	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Ag	ag	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	analysing	analyse	VBG	VBG	_	9	advcl	_	_
23	the	the	DT	DT	_	27	det	_	_
24	Ag	ag	NN	NN	_	27	compound	_	_
25	amino	amino	NN	NN	_	27	compound	_	_
26	acid	acid	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	22	dobj	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	algorithm	algorithm	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	constructed	construct	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	aim	aim	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	mark	_	_
9	identifying	identify	VBG	VBG	_	7	acl	_	_
10	segments	segment	NNS	NNS	_	9	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	Ag	ag	NN	NN	_	10	nmod	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	resistant	resistant	JJ	JJ	_	10	acl:relcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	proteolytic	proteolytic	JJ	JJ	_	18	amod	_	_
18	degradation	degradation	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	enzymes	enzyme	NNS	NNS	_	22	compound	_	_
22	cathepsin	cathepsin	NN	NN	_	18	nmod	_	_
23	B	b	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	L	l	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	D	d	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	prominent	prominent	JJ	JJ	_	4	amod	_	_
4	enzymes	enzyme	NNS	NNS	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	endocytic	endocytic	JJ	JJ	_	8	amod	_	_
8	pathway	pathway	NN	NN	_	4	nmod	_	_
9	through	through	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	14	nmod	_	_
11	soluble	soluble	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	Ag	ag	NN	NN	_	14	nsubj	_	_
14	enter	enter	VBP	VBP	_	8	acl:relcl	_	_
15	APC	apc	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	4	punct	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	resistant	resistant	JJ	JJ	_	19	amod	_	_
19	segments	segment	NNS	NNS	_	27	nsubjpass	_	_
20	in	in	IN	IN	_	21	case	_	_
21	Ag	ag	NN	NN	_	19	nmod	_	_
22	may	may	MD	MD	_	27	aux	_	_
23	,	,	,	,	_	27	punct	_	_
24	therefore	therefore	RB	RB	_	27	advmod	_	_
25	,	,	,	,	_	27	punct	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	expected	expect	VBN	VBN	_	4	conj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	contain	contain	VB	VB	_	27	xcomp	_	_
30	more	more	JJR	JJR	_	32	amod	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	determinants	determinant	NNS	NNS	_	29	dobj	_	_
33	than	than	IN	IN	_	35	case	_	_
34	susceptible	susceptible	JJ	JJ	_	35	amod	_	_
35	segments	segment	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	From	from	IN	IN	_	2	case	_	_
2	information	information	NN	NN	_	18	nmod	_	_
3	available	available	JJ	JJ	_	2	amod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	literature	literature	NN	NN	_	3	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	substrate	substrate	JJ	JJ	_	10	amod	_	_
10	specificity	specificity	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	enzymes	enzyme	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	it	it	PRP	PRP	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	clear	clear	JJ	JJ	_	0	root	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	a	a	DT	DT	_	21	det	_	_
21	cysteine	cysteine	NN	NN	_	24	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	accepted	accept	VBN	VBN	_	18	ccomp	_	_
25	in	in	IN	IN	_	26	case	_	_
26	any	any	DT	DT	_	24	nmod	_	_
27	of	of	IN	IN	_	37	case	_	_
28	the	the	DT	DT	_	37	det	_	_
29	S2	s2	NN	NN	_	37	compound	_	_
30	,	,	,	,	_	29	punct	_	_
31	S1	s1	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	S1'	s1'	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	S2'	s2'	NN	NN	_	29	conj	_	_
37	subsites	subsite	NNS	NNS	_	26	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	cathepsin	cathepsin	NN	NN	_	37	nmod	_	_
40	B	b	NN	NN	_	39	dep	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	L	l	NN	NN	_	40	conj	_	_
43	,	,	,	,	_	26	punct	_	_
44	and	and	CC	CC	_	26	cc	_	_
45	not	not	RB	RB	_	51	neg	_	_
46	in	in	IN	IN	_	51	case	_	_
47	the	the	DT	DT	_	51	det	_	_
48	S1	s1	NN	NN	_	51	compound	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	S1'	s1'	NN	NN	_	48	conj	_	_
51	subsites	subsite	NNS	NNS	_	26	conj	_	_
52	of	of	IN	IN	_	54	case	_	_
53	cathepsin	cathepsin	NN	NN	_	54	compound	_	_
54	D	d	NN	NN	_	51	nmod	_	_
55	.	.	.	.	_	18	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	noticed	notice	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	cysteine-containing	cysteine-containing	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	determinants	determinant	NNS	NNS	_	18	nsubj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	Ag	ag	NN	NN	_	12	nmod	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	particularly	particularly	RB	RB	_	18	advmod	_	_
18	rich	rich	JJ	JJ	_	5	ccomp	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	amino	amino	NN	NN	_	22	compound	_	_
22	acids	acid	NNS	NNS	_	18	nmod	_	_
23	alanine	alanine	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	glycine	glycine	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	lysine	lysine	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	leucine	leucine	NN	NN	_	23	conj	_	_
30	,	,	,	,	_	23	punct	_	_
31	serine	serine	NN	NN	_	23	conj	_	_
32	,	,	,	,	_	23	punct	_	_
33	threonine	threonine	NN	NN	_	23	conj	_	_
34	,	,	,	,	_	23	punct	_	_
35	and	and	CC	CC	_	23	cc	_	_
36	valine	valine	NN	NN	_	23	conj	_	_
37	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	searching	search	VBG	VBG	_	21	advcl	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	Ag	ag	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	clusters	cluster	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	amino	amino	NN	NN	_	9	compound	_	_
9	acids	acid	NNS	NNS	_	6	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	cysteine	cysteine	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	two	two	CD	CD	_	6	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	amino	amino	NN	NN	_	18	compound	_	_
18	acids	acid	NNS	NNS	_	13	nmod	_	_
19	we	we	PRP	PRP	_	21	nsubj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	able	able	JJ	JJ	_	0	root	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	predict	predict	VB	VB	_	21	xcomp	_	_
24	17	17	CD	CD	_	27	compound	_	_
25	out	out	IN	IN	_	27	advmod	_	_
26	of	of	IN	IN	_	27	advmod	_	_
27	23	23	CD	CD	_	31	nummod	_	_
28	empirically	empirically	RB	RB	_	29	advmod	_	_
29	known	know	VBN	VBN	_	31	amod	_	_
30	T-cell	t-cell	NN	NN	_	31	compound	_	_
31	determinants	determinant	NNS	NNS	_	23	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	Ag	ag	NN	NN	_	31	nmod	_	_
35	with	with	IN	IN	_	39	case	_	_
36	a	a	DT	DT	_	39	det	_	_
37	relatively	relatively	RB	RB	_	38	advmod	_	_
38	low	low	JJ	JJ	_	39	amod	_	_
39	number	number	NN	NN	_	23	nmod	_	_
40	of	of	IN	IN	_	45	case	_	_
41	false	false	JJ	JJ	_	45	amod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	positive	positive	JJ	JJ	_	41	dep	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	predictions	prediction	NNS	NNS	_	39	nmod	_	_
46	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	present	present	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	principle	principle	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	9	mark	_	_
9	searching	search	VBG	VBG	_	7	acl	_	_
10	Ag	ag	NN	NN	_	9	dobj	_	_
11	for	for	IN	IN	_	16	case	_	_
12	potential	potential	JJ	JJ	_	16	amod	_	_
13	amphipatic	amphipatic	JJ	JJ	_	16	amod	_	_
14	alpha-helical	alpha-helical	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	segments	segment	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	segments	segment	NNS	NNS	_	3	nsubj	_	_
3	accord	accord	VBP	VBP	_	0	root	_	_
4	well	well	RB	RB	_	3	advmod	_	_
5	with	with	IN	IN	_	9	case	_	_
6	empirically	empirically	RB	RB	_	7	advmod	_	_
7	known	known	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	determinants	determinant	NNS	NNS	_	3	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	our	we	PRP$	PRP$	_	12	nmod:poss	_	_
12	algorithm	algorithm	NN	NN	_	13	nsubj	_	_
13	produces	produce	VBZ	VBZ	_	3	conj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	lower	lower	JJR	JJR	_	16	amod	_	_
16	number	number	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	false	false	JJ	JJ	_	20	amod	_	_
19	positive	positive	JJ	JJ	_	20	amod	_	_
20	predictions	prediction	NNS	NNS	_	16	nmod	_	_
21	than	than	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	principle	principle	NN	NN	_	16	nmod	_	_
24	based	base	VBN	VBN	_	28	case	_	_
25	on	on	IN	IN	_	28	case	_	_
26	discrete	discrete	JJ	JJ	_	28	amod	_	_
27	Fourier	fourier	NN	NN	_	28	compound	_	_
28	transformations	transformation	NNS	NNS	_	23	nmod	_	_
29	previously	previously	RB	RB	_	30	advmod	_	_
30	described	describe	VBN	VBN	_	28	acl	_	_
31	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	putative	putative	JJ	JJ	_	7	amod	_	_
4	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
5	G0/G1	g0/g1	NN	NN	_	7	compound	_	_
6	switch	switch	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	12	nsubj	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	11	det	_	_
10	CpG-rich	cpg-rich	JJ	JJ	_	11	amod	_	_
11	island	island	NN	NN	_	8	dobj	_	_
12	encodes	encode	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	16	det	_	_
14	small	small	JJ	JJ	_	16	amod	_	_
15	basic	basic	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	12	dobj	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	potential	potential	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	phosphorylated	phosphorylate	VBN	VBN	_	19	acl	_	_
23	.	.	.	.	_	12	punct	_	_

1	Genes	gene	NNS	NNS	_	15	nsubjpass	_	_
2	actively	actively	RB	RB	_	3	advmod	_	_
3	involved	involve	VBN	VBN	_	1	acl	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	G0/G1	g0/g1	NN	NN	_	7	compound	_	_
7	switch	switch	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	G0S	g0s	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	1	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	may	may	MD	MD	_	15	aux	_	_
13	be	be	VB	VB	_	15	auxpass	_	_
14	differentially	differentially	RB	RB	_	15	advmod	_	_
15	expressed	express	VBN	VBN	_	0	root	_	_
16	during	during	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	lectin-induced	lectin-induced	JJ	JJ	_	19	amod	_	_
19	switch	switch	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
22	from	from	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	G0	g0	NN	NN	_	19	nmod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	G1	g1	NN	NN	_	28	compound	_	_
28	phases	phase	NNS	NNS	_	19	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	cycle	cycle	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	presents	present	VBZ	VBZ	_	0	root	_	_
4	studies	study	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	G0S2	g0s2	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	9	det	_	_
9	member	member	NN	NN	_	6	appos	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	set	set	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	putative	putative	JJ	JJ	_	16	amod	_	_
15	G0S	g0s	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	for	for	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	22	nmod	_	_
20	cDNAs	cdna	NNS	NNS	_	22	nsubj	_	_
21	were	be	VBD	VBD	_	22	aux	_	_
22	cloned	clone	VBN	VBN	_	6	acl:relcl	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	selected	select	VBN	VBN	_	22	conj	_	_
25	on	on	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	dep	_	_
27	basis	basis	NN	NN	_	31	dep	_	_
28	of	of	IN	IN	_	31	case	_	_
29	differential	differential	JJ	JJ	_	31	amod	_	_
30	cDNA	cdna	NN	NN	_	31	compound	_	_
31	hybridization	hybridization	NN	NN	_	22	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	G0S2	g0s2	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	3	nsubj	_	_
3	increases	increase	VBZ	VBZ	_	0	root	_	_
4	transiently	transiently	RB	RB	_	3	advmod	_	_
5	within	within	IN	IN	_	7	case	_	_
6	1-2	1-2	CD	CD	_	7	nummod	_	_
7	hr	hr	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	addition	addition	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	lectin	lectin	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	cycloheximide	cycloheximide	NN	NN	_	12	conj	_	_
15	to	to	TO	TO	_	19	case	_	_
16	cultured	culture	VBN	VBN	_	19	amod	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	mononuclear	mononuclear	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Comparison	comparison	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	nearly	nearly	RB	RB	_	5	advmod	_	_
5	full-length	full-length	JJ	JJ	_	7	amod	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	corresponding	corresponding	JJ	JJ	_	12	amod	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	1	nmod	_	_
13	reveals	reveal	VBZ	VBZ	_	0	root	_	_
14	one	one	CD	CD	_	16	nummod	_	_
15	small	small	JJ	JJ	_	16	amod	_	_
16	intron	intron	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	an	a	DT	DT	_	21	det	_	_
19	open	open	JJ	JJ	_	21	amod	_	_
20	reading	reading	NN	NN	_	21	compound	_	_
21	frame	frame	NN	NN	_	16	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	second	second	JJ	JJ	_	25	amod	_	_
25	exon	exon	NN	NN	_	16	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	derived	derive	VBN	VBN	_	5	amod	_	_
3	103-amino-acid	103-amino-acid	JJ	JJ	_	5	amod	_	_
4	basic	basic	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	0	root	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	potential	potential	JJ	JJ	_	10	amod	_	_
9	alpha-helical	alpha-helical	JJ	JJ	_	10	amod	_	_
10	domains	domain	NNS	NNS	_	6	dobj	_	_
11	separated	separate	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	hydrophobic	hydrophobic	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	11	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	potential	potential	NN	NN	_	15	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	generate	generate	VB	VB	_	18	acl	_	_
21	turns	turn	NNS	NNS	_	20	dobj	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	assume	assume	VB	VB	_	20	conj	_	_
24	a	a	DT	DT	_	26	det	_	_
25	beta-sheet	beta-sheet	JJ	JJ	_	26	amod	_	_
26	conformation	conformation	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Consistent	consistent	JJ	JJ	_	11	ccomp	_	_
2	with	with	IN	IN	_	3	case	_	_
3	involvement	involvement	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	G0/G1	g0/g1	NN	NN	_	7	compound	_	_
7	switch	switch	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	protein	protein	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	potential	potential	JJ	JJ	_	13	amod	_	_
13	sites	site	NNS	NNS	_	11	dobj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	C	c	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	casein	casein	NN	NN	_	22	compound	_	_
22	kinase	kinase	NN	NN	_	19	conj	_	_
23	II	ii	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	CpG-rich	cpg-rich	JJ	JJ	_	6	amod	_	_
6	island	island	NN	NN	_	3	dobj	_	_
7	suggesting	suggest	VBG	VBG	_	3	xcomp	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	germ	germ	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	upstream	upstream	JJ	JJ	_	3	amod	_	_
3	segment	segment	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	tandem	tandem	JJ	JJ	_	8	amod	_	_
6	dinucleotide	dinucleotide	NN	NN	_	8	compound	_	_
7	repeats	repeat	NNS	NNS	_	8	compound	_	_
8	(CT)19/(CA)16	(ct)19/(ca)16	NN	NN	_	4	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	suitably	suitably	RB	RB	_	5	advmod	_	_
5	located	located	JJ	JJ	_	7	amod	_	_
6	TATA	tata	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	2	nsubj	_	_
8	,	,	,	,	_	2	punct	_	_
9	but	but	CC	CC	_	2	cc	_	_
10	potential	potential	JJ	JJ	_	11	amod	_	_
11	sites	site	NNS	NNS	_	18	nsubj	_	_
12	for	for	IN	IN	_	15	case	_	_
13	CCAAT-box	ccaat-box	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	far	far	RB	RB	_	18	advmod	_	_
18	upstream	upstream	JJ	JJ	_	2	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	embedded	embedded	JJ	JJ	_	18	xcomp	_	_
21	in	in	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	42-nucleotide	42-nucleotide	JJ	JJ	_	25	amod	_	_
24	repeat	repeat	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Potential	potential	JJ	JJ	_	2	amod	_	_
2	sites	site	NNS	NNS	_	13	nsubj	_	_
3	for	for	IN	IN	_	5	case	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	AP1	ap1	NN	NN	_	5	dep	_	_
7	,	,	,	,	_	6	punct	_	_
8	AP2	ap2	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	AP3	ap3	NN	NN	_	6	conj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	consistent	consistent	JJ	JJ	_	0	root	_	_
14	with	with	IN	IN	_	17	case	_	_
15	rapid	rapid	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	response	response	NN	NN	_	22	dep	_	_
20	to	to	TO	TO	_	22	case	_	_
21	inducing	induce	VBG	VBG	_	22	amod	_	_
22	agents	agent	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Synergism	synergism	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	5	case	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HTLV-I	htlv-i	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	5	nmod	_	_
10	during	during	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	1	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	trans-activator	trans-activator	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	HTLV-I	htlv-i	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	conducted	conduct	VBN	VBN	_	0	root	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	studies	study	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	enhancer	enhancer	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	T-cell	t-cell	NN	NN	_	15	compound	_	_
13	leukemia	leukemia	NN	NN	_	15	compound	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	type	type	NN	NN	_	9	nmod	_	_
16	I	i	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HTLV-I	htlv-i	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	using	use	VBG	VBG	_	3	xcomp	_	_
21	the	the	DT	DT	_	24	det	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	20	dobj	_	_
25	Jurkat	jurkat	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	MOLT	molt	NN	NN	_	25	conj	_	_
28	4	4	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	25	punct	_	_
30	which	which	WDT	WDT	_	32	nsubj	_	_
31	are	be	VBP	VBP	_	32	cop	_	_
32	negative	negative	JJ	JJ	_	25	acl:relcl	_	_
33	for	for	IN	IN	_	34	case	_	_
34	HTLV-I	htlv-i	NN	NN	_	32	nmod	_	_
35	,	,	,	,	_	25	punct	_	_
36	and	and	CC	CC	_	25	cc	_	_
37	MT-2	mt-2	NN	NN	_	25	conj	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	TL-Mor	tl-mor	NN	NN	_	37	conj	_	_
40	,	,	,	,	_	37	punct	_	_
41	which	which	WDT	WDT	_	42	nsubj	_	_
42	carry	carry	VBP	VBP	_	37	acl:relcl	_	_
43	the	the	DT	DT	_	45	det	_	_
44	proviral	proviral	JJ	JJ	_	45	amod	_	_
45	genome	genome	NN	NN	_	42	dobj	_	_
46	of	of	IN	IN	_	47	case	_	_
47	HTLV-I	htlv-i	NN	NN	_	45	nmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	distinct	distinct	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	implicated	implicate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	function	function	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	HTLV-I	htlv-i	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	9	nsubj	_	_
2	is	be	VBZ	VBZ	_	9	cop	_	_
3	the	the	DT	DT	_	9	det	_	_
4	21-base-pair	21-base-pair	JJ	JJ	_	9	amod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	bp	bp	NN	NN	_	4	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	core	core	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	responsible	responsible	JJ	JJ	_	9	acl:relcl	_	_
13	for	for	IN	IN	_	14	case	_	_
14	trans-activation	trans-activation	NN	NN	_	12	nmod	_	_
15	by	by	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	HTLV-I	htlv-i	NN	NN	_	19	compound	_	_
18	trans-activator	trans-activator	NN	NN	_	19	compound	_	_
19	p40tax	p40tax	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	has	have	VBZ	VBZ	_	12	conj	_	_
23	the	the	DT	DT	_	24	det	_	_
24	ability	ability	NN	NN	_	22	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	bind	bind	VB	VB	_	24	acl	_	_
27	to	to	TO	TO	_	39	case	_	_
28	cyclic-AMP	cyclic-amp	NN	NN	_	36	nmod:npmod	_	_
29	responsive	responsive	JJ	JJ	_	36	amod	_	_
30	element	element	NN	NN	_	36	nmod:npmod	_	_
31	binding	binding	NN	NN	_	36	nmod:npmod	_	_
32	factor	factor	NN	NN	_	36	nmod:npmod	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	CREB	creb	NN	NN	_	36	nmod:npmod	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	-like	-like	JJ	JJ	_	39	amod	_	_
37	factor	factor	NN	NN	_	39	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	s	s	NNS	NNS	_	26	nmod	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	other	other	JJ	JJ	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	a	a	DT	DT	_	5	det	_	_
5	region	region	NN	NN	_	0	root	_	_
6	interposed	interpose	VBN	VBN	_	5	amod	_	_
7	between	between	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	21-bp	21-bp	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	20	mark	_	_
7	a	a	DT	DT	_	8	det	_	_
8	subfragment	subfragment	NN	NN	_	20	nsubjpass	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	C26	c26	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	region	region	NN	NN	_	8	nmod	_	_
15	between	between	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	21-bp	21-bp	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	14	nmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	5	ccomp	_	_
21	in	in	IN	IN	_	22	case	_	_
22	trans-activation	trans-activation	NN	NN	_	20	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	p40tax	p40tax	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	20	punct	_	_
26	possibly	possibly	RB	RB	_	28	advmod	_	_
27	through	through	IN	IN	_	28	case	_	_
28	binding	binding	NN	NN	_	20	nmod	_	_
29	to	to	TO	TO	_	34	case	_	_
30	an	a	DT	DT	_	34	det	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	nmod:npmod	_	_
32	B-like	b-like	JJ	JJ	_	34	amod	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	28	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	factors	factor	NNS	NNS	_	34	conj	_	_
37	.	.	.	.	_	5	punct	_	_

1	Formation	formation	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	protein-DNA	protein-dna	JJ	JJ	_	5	amod	_	_
5	complex	complex	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	C26	c26	NN	NN	_	9	compound	_	_
9	subfragment	subfragment	NN	NN	_	1	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	positively	positively	RB	RB	_	12	advmod	_	_
12	affected	affect	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	p40tax	p40tax	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	C26	c26	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	4	nsubj	_	_
4	conferred	confer	VBD	VBD	_	0	root	_	_
5	partial	partial	JJ	JJ	_	6	amod	_	_
6	responsiveness	responsiveness	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	p40tax	p40tax	NN	NN	_	6	nmod	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	linked	link	VBN	VBN	_	4	advcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	copy	copy	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	21-bp	21-bp	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	13	nmod	_	_
18	that	that	WDT	WDT	_	23	nsubj	_	_
19	,	,	,	,	_	23	punct	_	_
20	by	by	IN	IN	_	21	case	_	_
21	itself	itself	PRP	PRP	_	23	nmod	_	_
22	,	,	,	,	_	23	punct	_	_
23	showed	show	VBD	VBD	_	13	acl:relcl	_	_
24	little	little	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	response	response	NN	NN	_	29	dep	_	_
28	to	to	TO	TO	_	29	case	_	_
29	p40tax	p40tax	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	C26	c26	NN	NN	_	5	compound	_	_
5	element	element	NN	NN	_	15	nsubjpass	_	_
6	alone	alone	RB	RB	_	5	advmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	even	even	RB	RB	_	9	advmod	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	repeated	repeat	VBN	VBN	_	15	advcl	_	_
11	,	,	,	,	_	15	punct	_	_
12	could	could	MD	MD	_	15	aux	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	p40tax	p40tax	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	unlike	unlike	IN	IN	_	23	case	_	_
20	other	other	JJ	JJ	_	23	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	nmod:npmod	_	_
22	B-binding	b-binding	JJ	JJ	_	23	amod	_	_
23	elements	element	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	C26	c26	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	10	nsubjpass	_	_
7	itself	itself	PRP	PRP	_	6	nmod:npmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	profoundly	profoundly	RB	RB	_	10	advmod	_	_
10	activated	activate	VBN	VBN	_	0	root	_	_
11	upon	upon	IN	IN	_	12	case	_	_
12	stimulation	stimulation	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HTLV-I	htlv-i	NN	NN	_	8	compound	_	_
8	enhancer	enhancer	NN	NN	_	9	nsubj	_	_
9	contains	contain	VBZ	VBZ	_	4	ccomp	_	_
10	multiple	multiple	JJ	JJ	_	11	amod	_	_
11	functional	functional	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	including	include	VBG	VBG	_	16	case	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	sites	site	NNS	NNS	_	12	nmod	_	_
17	for	for	IN	IN	_	24	case	_	_
18	at	at	IN	IN	_	19	dep	_	_
19	least	least	JJS	JJS	_	24	amod	_	_
20	CREB-	creb-	NN	NN	_	23	dep	_	_
21	and	and	CC	CC	_	23	cc	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	conj	_	_
23	B-like	b-like	JJ	JJ	_	24	amod	_	_
24	factors	factor	NNS	NNS	_	16	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	which	which	WDT	WDT	_	28	nsubj	_	_
27	synergistically	synergistically	RB	RB	_	28	advmod	_	_
28	cooperate	cooperate	VBP	VBP	_	12	acl:relcl	_	_
29	in	in	IN	IN	_	30	case	_	_
30	activation	activation	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	HTLV-I	htlv-i	NN	NN	_	34	compound	_	_
34	enhancer	enhancer	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	response	response	NN	NN	_	38	dep	_	_
37	to	to	TO	TO	_	38	case	_	_
38	p40tax	p40tax	NN	NN	_	30	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	TPA-dependent	tpa-dependent	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HTLV-I	htlv-i	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	7	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	4	ccomp	_	_
15	through	through	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	C26	c26	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	v-erbA	v-erba	NN	NN	_	2	compound	_	_
2	overexpression	overexpression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	extinguish	extinguish	VB	VB	_	4	xcomp	_	_
7	c-erbA	c-erba	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	differentiation	differentiation	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	regulation	regulation	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	erbA	erba	NN	NN	_	20	compound	_	_
18	target	target	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	CAII	caii	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	v-erbA	v-erba	NN	NN	_	3	compound	_	_
3	oncoprotein	oncoprotein	NN	NN	_	4	nsubj	_	_
4	represents	represent	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	retrovirus-transduced	retrovirus-transduced	JJ	JJ	_	8	amod	_	_
7	oncogenic	oncogenic	JJ	JJ	_	8	amod	_	_
8	version	version	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	20	case	_	_
10	the	the	DT	DT	_	20	det	_	_
11	thyroid	thyroid	NN	NN	_	20	compound	_	_
12	hormone	hormone	NN	NN	_	20	compound	_	_
13	(	(	-LRB-	-LRB-	_	20	punct	_	_
14	T3/T4	t3/t4	NN	NN	_	20	compound	_	_
15	)	)	-RRB-	-RRB-	_	20	punct	_	_
16	receptor	receptor	NN	NN	_	20	compound	_	_
17	c-erbA	c-erba	NN	NN	_	20	compound	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	type	type	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	8	nmod	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	contributes	contribute	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	virus-induced	virus-induced	JJ	JJ	_	5	amod	_	_
5	erythroleukemia	erythroleukemia	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	8	mark	_	_
7	efficiently	efficiently	RB	RB	_	8	advmod	_	_
8	arresting	arrest	VBG	VBG	_	2	dep	_	_
9	differentiation	differentiation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	red	red	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	progenitors	progenitor	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	suppressing	suppress	VBG	VBG	_	8	conj	_	_
17	transcription	transcription	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	erythrocyte-specific	erythrocyte-specific	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	v-erbA	v-erba	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-erbA	c-erba	NN	NN	_	6	conj	_	_
9	bind	bind	VBP	VBP	_	4	ccomp	_	_
10	directly	directly	RB	RB	_	9	advmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	sequences	sequence	NNS	NNS	_	9	nmod	_	_
13	within	within	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	promoter	promoter	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	erythrocyte-specific	erythrocyte-specific	JJ	JJ	_	20	amod	_	_
19	carbonic	carbonic	JJ	JJ	_	20	amod	_	_
20	anhydrase	anhydrase	NN	NN	_	15	nmod	_	_
21	II	ii	CD	CD	_	20	nummod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CAII	caii	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	20	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	gene	gene	NN	NN	_	20	appos	_	_
28	whose	whose	WP$	WP$	_	29	nmod:poss	_	_
29	transcription	transcription	NN	NN	_	32	nsubjpass	_	_
30	is	be	VBZ	VBZ	_	32	auxpass	_	_
31	efficiently	efficiently	RB	RB	_	32	advmod	_	_
32	suppressed	suppress	VBN	VBN	_	27	acl:relcl	_	_
33	by	by	IN	IN	_	34	case	_	_
34	v-erbA	v-erba	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	erbA-binding	erba-binding	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	4	nsubj	_	_
4	confers	confer	VBZ	VBZ	_	0	root	_	_
5	thyroid	thyroid	NN	NN	_	7	compound	_	_
6	hormone	hormone	NN	NN	_	7	compound	_	_
7	responsiveness	responsiveness	NN	NN	_	4	dobj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	heterologous	heterologous	JJ	JJ	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	transient	transient	JJ	JJ	_	15	amod	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	experiments	experiment	NNS	NNS	_	7	nmod	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	a	a	DT	DT	_	19	det	_	_
19	target	target	NN	NN	_	4	conj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	efficient	efficient	JJ	JJ	_	22	amod	_	_
22	down-regulation	down-regulation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	CAII	caii	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	22	nmod	_	_
26	by	by	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	v-erbA	v-erba	NN	NN	_	29	compound	_	_
29	oncoprotein	oncoprotein	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	stably	stably	RB	RB	_	3	advmod	_	_
3	transformed	transform	VBN	VBN	_	4	amod	_	_
4	erythroblasts	erythroblast	NNS	NNS	_	22	nmod	_	_
5	coexpressing	coexpress	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	v-erbA	v-erba	NN	NN	_	8	compound	_	_
8	oncoprotein	oncoprotein	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	c-erbA/T3	c-erba/t3	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	8	conj	_	_
13	at	at	IN	IN	_	17	case	_	_
14	an	a	DT	DT	_	17	det	_	_
15	approximately	approximately	RB	RB	_	16	advmod	_	_
16	equimolar	equimolar	JJ	JJ	_	17	amod	_	_
17	ratio	ratio	NN	NN	_	5	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	c-erbA	c-erba	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	dominant	dominant	JJ	JJ	_	0	root	_	_
23	over	over	IN	IN	_	24	case	_	_
24	v-erbA	v-erba	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	22	punct	_	_

1	T3	t3	NN	NN	_	3	nsubj	_	_
2	efficiently	efficiently	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	thus	thus	RB	RB	_	3	advmod	_	_
11	overcoming	overcome	VBG	VBG	_	3	xcomp	_	_
12	the	the	DT	DT	_	15	det	_	_
13	v-erbA-mediated	v-erba-mediated	JJ	JJ	_	15	amod	_	_
14	differentiation	differentiation	NN	NN	_	15	compound	_	_
15	arrest	arrest	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Likewise	likewise	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	T3	t3	NN	NN	_	4	nsubj	_	_
4	activated	activate	VBD	VBD	_	0	root	_	_
5	CAII	caii	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	4	dobj	_	_
7	as	as	RB	RB	_	6	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	transient	transient	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	6	conj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	T3-responsive	t3-responsive	JJ	JJ	_	16	amod	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	containing	contain	VBG	VBG	_	16	acl	_	_
18	the	the	DT	DT	_	21	det	_	_
19	CAII-specific	caii-specific	JJ	JJ	_	21	amod	_	_
20	erbA-binding	erba-binding	JJ	JJ	_	21	amod	_	_
21	site	site	NN	NN	_	17	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	c-erbA-dependent	c-erba-dependent	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	this	this	DT	DT	_	8	det	_	_
6	CAII	caii	NN	NN	_	8	compound	_	_
7	reporter	reporter	NN	NN	_	8	compound	_	_
8	construct	construct	NN	NN	_	3	nmod	_	_
9	could	could	MD	MD	_	12	aux	_	_
10	only	only	RB	RB	_	12	advmod	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	suppressed	suppress	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	very	very	RB	RB	_	15	advmod	_	_
15	high	high	JJ	JJ	_	16	amod	_	_
16	amounts	amount	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	v-erbA	v-erba	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	overexpression	overexpression	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	v-erbA	v-erba	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	required	require	VBN	VBN	_	3	ccomp	_	_
10	for	for	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	function	function	NN	NN	_	9	nmod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	oncoprotein	oncoprotein	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	phorbol	phorbol	NN	NN	_	4	nmod:npmod	_	_
4	ester-induced	ester-induced	JJ	JJ	_	6	amod	_	_
5	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
6	differentiation	differentiation	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	down-regulation	down-regulation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	c-fos	c-fos	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	c-jun	c-jun	NN	NN	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	AP-1	ap-1	NN	NN	_	14	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	10	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	18	mark	_	_
6	treatment	treatment	NN	NN	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TPA	tpa	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	4	ccomp	_	_
19	with	with	IN	IN	_	20	case	_	_
20	induction	induction	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	expression	expression	NN	NN	_	23	conj	_	_
26	of	of	IN	IN	_	33	case	_	_
27	the	the	DT	DT	_	33	det	_	_
28	c-jun	c-jun	NN	NN	_	33	compound	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	c-fos	c-fos	NN	NN	_	28	conj	_	_
31	early	early	JJ	JJ	_	33	amod	_	_
32	response	response	NN	NN	_	33	compound	_	_
33	genes	gene	NNS	NNS	_	23	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	dexamethasone	dexamethasone	NN	NN	_	9	nsubj	_	_
9	inhibits	inhibit	VBZ	VBZ	_	4	ccomp	_	_
10	TPA-induced	tpa-induced	JJ	JJ	_	11	amod	_	_
11	increases	increase	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	c-jun	c-jun	NN	NN	_	17	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-fos	c-fos	NN	NN	_	13	conj	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	11	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	U-937	u-937	NN	NN	_	21	compound	_	_
20	leukemia	leukemia	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	block	block	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	appearance	appearance	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	phenotype	phenotype	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	including	include	VBG	VBG	_	16	case	_	_
16	inhibition	inhibition	NN	NN	_	7	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	TPA-induced	tpa-induced	JJ	JJ	_	19	amod	_	_
19	increases	increase	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	lamin	lamin	NN	NN	_	22	compound	_	_
22	A	a	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	lamin	lamin	NN	NN	_	25	compound	_	_
25	C	c	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	vimentin	vimentin	NN	NN	_	29	compound	_	_
29	transcripts	transcript	NNS	NNS	_	22	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	22	mark	_	_
6	TPA-induced	tpa-induced	JJ	JJ	_	8	amod	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	22	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	expression	expression	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	c-jun	c-jun	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-fos	c-fos	NN	NN	_	13	conj	_	_
16	genes	gene	NNS	NNS	_	8	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	myeloid	myeloid	JJ	JJ	_	20	amod	_	_
19	leukemia	leukemia	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
23	by	by	IN	IN	_	26	case	_	_
24	protein	protein	NN	NN	_	26	compound	_	_
25	kinase	kinase	NN	NN	_	26	compound	_	_
26	C	c	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PKC	pkc	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	13	nsubj	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	dexamethasone	dexamethasone	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	2	ccomp	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	TPA-induced	tpa-induced	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	PKC	pkc	NN	NN	_	10	nmod	_	_
13	suggests	suggest	VBZ	VBZ	_	0	root	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	this	this	DT	DT	_	16	det	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	nsubj	_	_
17	inhibits	inhibit	VBZ	VBZ	_	13	ccomp	_	_
18	signals	signal	NNS	NNS	_	17	dobj	_	_
19	downstream	downstream	JJ	JJ	_	18	amod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	parallel	parallel	JJ	JJ	_	19	conj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	enzyme	enzyme	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	:	:	:	:	_	19	punct	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	19	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	induction	induction	NN	NN	_	19	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	c-jun	c-jun	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	c-fos	c-fos	NN	NN	_	12	conj	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	TPA	tpa	NN	NN	_	10	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
20	by	by	IN	IN	_	22	case	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	mechanisms	mechanism	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	19	punct	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	2	2	LS	LS	_	35	dep	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	TPA-induced	tpa-induced	JJ	JJ	_	28	amod	_	_
28	expression	expression	NN	NN	_	35	nsubj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	c-jun	c-jun	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	c-fos	c-fos	NN	NN	_	30	conj	_	_
33	does	do	VBZ	VBZ	_	35	aux	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	require	require	VB	VB	_	19	ccomp	_	_
36	protein	protein	NN	NN	_	37	compound	_	_
37	synthesis	synthesis	NN	NN	_	35	dobj	_	_
38	,	,	,	,	_	19	punct	_	_
39	and	and	CC	CC	_	19	cc	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	3	3	LS	LS	_	49	dep	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	TPA-induced	tpa-induced	JJ	JJ	_	44	amod	_	_
44	expression	expression	NN	NN	_	49	nsubjpass	_	_
45	of	of	IN	IN	_	47	case	_	_
46	both	both	DT	DT	_	47	det	_	_
47	genes	gene	NNS	NNS	_	44	nmod	_	_
48	is	be	VBZ	VBZ	_	49	auxpass	_	_
49	inhibited	inhibit	VBN	VBN	_	19	conj	_	_
50	at	at	IN	IN	_	53	case	_	_
51	the	the	DT	DT	_	53	det	_	_
52	transcriptional	transcriptional	JJ	JJ	_	53	amod	_	_
53	level	level	NN	NN	_	49	nmod	_	_
54	by	by	IN	IN	_	55	case	_	_
55	dexamethasone	dexamethasone	NN	NN	_	49	nmod	_	_
56	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	define	define	VB	VB	_	14	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	level	level	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	prepared	prepare	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	16	det	_	_
16	series	series	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	deleted	delete	VBN	VBN	_	21	amod	_	_
19	c-jun	c-jun	NN	NN	_	21	compound	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	fragments	fragment	NNS	NNS	_	16	nmod	_	_
22	linked	link	VBN	VBN	_	21	acl	_	_
23	to	to	TO	TO	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	chloramphenicol	chloramphenicol	NN	NN	_	26	compound	_	_
26	acetyltransferase	acetyltransferase	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CAT	cat	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	gene	gene	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	Increases	increase	NNS	NNS	_	17	nsubjpass	_	_
2	in	in	IN	IN	_	4	case	_	_
3	CAT	cat	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	during	during	IN	IN	_	7	case	_	_
6	transient	transient	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	constructs	construct	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	TPA-treated	tpa-treated	JJ	JJ	_	14	amod	_	_
13	U-937	u-937	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	assigned	assign	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	region	region	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	-97	-97	CD	CD	_	20	dep	_	_
23	to	to	TO	TO	_	22	dep	_	_
24	-20	-20	CD	CD	_	22	dep	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	promoter	promoter	NN	NN	_	20	nmod	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	contains	contain	VBZ	VBZ	_	20	acl:relcl	_	_
31	the	the	DT	DT	_	34	det	_	_
32	AP-1	ap-1	NN	NN	_	34	compound	_	_
33	binding	binding	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CAT	cat	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	sensitive	sensitive	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	dexamethasone	dexamethasone	NN	NN	_	6	nsubj	_	_
6	down-regulates	down-regulate	VBZ	VBZ	_	3	ccomp	_	_
7	TPA-induced	tpa-induced	JJ	JJ	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	c-jun	c-jun	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	6	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
18	activation	activation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	AP-1	ap-1	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Charybdotoxin-sensitive	charybdotoxin-sensitive	JJ	JJ	_	6	amod	_	_
2	,	,	,	,	_	1	punct	_	_
3	Ca(2+)-dependent	ca(2+)-dependent	JJ	JJ	_	1	dep	_	_
4	membrane	membrane	NN	NN	_	6	compound	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	changes	change	NNS	NNS	_	9	nsubjpass	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	T	t	NN	NN	_	15	compound	_	_
13	or	or	CC	CC	_	15	cc	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cell	cell	NN	NN	_	9	nmod	_	_
16	activation	activation	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	proliferation	proliferation	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	ion	ion	NN	NN	_	5	compound	_	_
5	channels	channel	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	11	case	_	_
7	B	b	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	T	t	NN	NN	_	7	conj	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	2	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	supported	support	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	reports	report	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	changes	change	NNS	NNS	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	ion	ion	NN	NN	_	21	compound	_	_
21	fluxes	flux	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	membrane	membrane	NN	NN	_	24	compound	_	_
24	potential	potential	NN	NN	_	21	conj	_	_
25	after	after	IN	IN	_	27	case	_	_
26	mitogen	mitogen	NN	NN	_	27	compound	_	_
27	binding	binding	NN	NN	_	18	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	T	t	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	conj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	11	det	_	_
8	early	early	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	transient	transient	JJ	JJ	_	8	conj	_	_
11	hyperpolarization	hyperpolarization	NN	NN	_	6	dobj	_	_
12	after	after	IN	IN	_	14	case	_	_
13	ligand	ligand	JJ	JJ	_	14	amod	_	_
14	binding	binding	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Inasmuch	inasmuch	RB	RB	_	9	advmod	_	_
2	as	as	IN	IN	_	9	mark	_	_
3	the	the	DT	DT	_	4	det	_	_
4	change	change	NN	NN	_	9	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	potential	potential	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	dependent	dependent	JJ	JJ	_	22	advcl	_	_
10	on	on	IN	IN	_	11	case	_	_
11	elevation	elevation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	free	free	JJ	JJ	_	15	amod	_	_
14	cytosolic	cytosolic	JJ	JJ	_	15	amod	_	_
15	calcium	calcium	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	22	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	hyperpolarization	hyperpolarization	NN	NN	_	22	nsubj	_	_
19	is	be	VBZ	VBZ	_	22	cop	_	_
20	presumably	presumably	RB	RB	_	22	advmod	_	_
21	through	through	IN	IN	_	22	case	_	_
22	opening	opening	NN	NN	_	0	root	_	_
23	of	of	IN	IN	_	26	case	_	_
24	Ca(2+)-stimulated	ca(2+)-stimulated	JJ	JJ	_	26	amod	_	_
25	K+	k+	NN	NN	_	26	compound	_	_
26	channels	channel	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	charybdotoxin	charybdotoxin	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	known	known	JJ	JJ	_	8	amod	_	_
8	inhibitor	inhibitor	NN	NN	_	4	appos	_	_
9	of	of	IN	IN	_	12	case	_	_
10	Ca(2+)-dependent	ca(2+)-dependent	JJ	JJ	_	12	amod	_	_
11	K+	k+	NN	NN	_	12	compound	_	_
12	channels	channel	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	study	study	VB	VB	_	3	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	channels	channel	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	lymphocyte	lymphocyte	NN	NN	_	17	nmod	_	_
23	activation	activation	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	mitogenesis	mitogenesis	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	charybdotoxin	charybdotoxin	NN	NN	_	5	nsubj	_	_
5	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
6	the	the	DT	DT	_	10	det	_	_
7	ligand-induced	ligand-induced	JJ	JJ	_	10	amod	_	_
8	transient	transient	JJ	JJ	_	10	amod	_	_
9	membrane	membrane	NN	NN	_	10	compound	_	_
10	hyperpolarization	hyperpolarization	NN	NN	_	5	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	B	b	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	T	t	NN	NN	_	12	conj	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	fashion	fashion	NN	NN	_	5	nmod	_	_
20	,	,	,	,	_	5	punct	_	_
21	without	without	IN	IN	_	22	mark	_	_
22	affecting	affect	VBG	VBG	_	5	advcl	_	_
23	changes	change	NNS	NNS	_	22	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	cytosolic	cytosolic	JJ	JJ	_	26	amod	_	_
26	Ca2+	ca2+	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	blockade	blockade	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	Ca(2+)-activated	ca(2+)-activated	JJ	JJ	_	8	amod	_	_
7	K+	k+	NN	NN	_	8	compound	_	_
8	channel	channel	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	associated	associate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	changes	change	NNS	NNS	_	11	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	cell-cycle	cell-cycle	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	17	punct	_	_
22	IL-2R	il-2r	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	17	conj	_	_
24	or	or	CC	CC	_	17	cc	_	_
25	B	b	NN	NN	_	29	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	T	t	NN	NN	_	25	conj	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	mitogenesis	mitogenesis	NN	NN	_	17	conj	_	_
30	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	membrane	membrane	NN	NN	_	7	compound	_	_
6	potential	potential	JJ	JJ	_	7	amod	_	_
7	changes	change	NNS	NNS	_	19	nsubjpass	_	_
8	secondary	secondary	JJ	JJ	_	7	amod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ligand-dependent	ligand-dependent	JJ	JJ	_	12	amod	_	_
12	opening	opening	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	Ca(2+)-activated	ca(2+)-activated	JJ	JJ	_	16	amod	_	_
15	K+	k+	NN	NN	_	16	compound	_	_
16	channels	channel	NNS	NNS	_	12	nmod	_	_
17	are	be	VBP	VBP	_	19	auxpass	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	involved	involve	VBN	VBN	_	3	ccomp	_	_
20	in	in	IN	IN	_	24	case	_	_
21	B	b	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	T	t	NN	NN	_	21	conj	_	_
24	lymphocyte	lymphocyte	NN	NN	_	19	nmod	_	_
25	activation	activation	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	mitogenesis	mitogenesis	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Evaluation	evaluation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	ligand	ligand	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	thermal	thermal	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	6	nmod	_	_
14	by	by	IN	IN	_	20	case	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	17	advmod	_	_
17	synthesized	synthesize	VBN	VBN	_	20	amod	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	DNA-binding/immunoprecipitation	dna-binding/immunoprecipitation	JJ	JJ	_	6	amod	_	_
6	assay	assay	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	analyze	analyze	VB	VB	_	3	advcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	capacity	capacity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	hGR	hgr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	generated	generate	VBN	VBN	_	14	acl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	rabbit	rabbit	NN	NN	_	23	compound	_	_
22	reticulocyte	reticulocyte	NN	NN	_	23	compound	_	_
23	lysates	lysate	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	10	punct	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	bind	bind	VB	VB	_	8	advcl	_	_
27	DNA	dna	NN	NN	_	26	dobj	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	3	advmod	_	_
3	translated	translate	VBN	VBN	_	4	amod	_	_
4	hGR	hgr	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
7	from	from	IN	IN	_	9	case	_	_
8	native	native	JJ	JJ	_	9	amod	_	_
9	hGR	hgr	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	as	as	IN	IN	_	12	mark	_	_
12	determined	determine	VBN	VBN	_	6	advcl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	migration	migration	NN	NN	_	12	nmod	_	_
15	on	on	IN	IN	_	19	case	_	_
16	sodium	sodium	NN	NN	_	18	nmod:npmod	_	_
17	dodecyl	dodecyl	NN	NN	_	18	nmod:npmod	_	_
18	sulfate-polyacrylamide	sulfate-polyacrylamide	JJ	JJ	_	19	amod	_	_
19	gels	gel	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	sedimentation	sedimentation	NN	NN	_	14	conj	_	_
22	on	on	IN	IN	_	25	case	_	_
23	sucrose	sucrose	NN	NN	_	25	compound	_	_
24	density	density	NN	NN	_	25	compound	_	_
25	gradients	gradient	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	and	and	CC	CC	_	14	cc	_	_
28	reactivity	reactivity	NN	NN	_	14	conj	_	_
29	with	with	IN	IN	_	31	case	_	_
30	antipeptide	antipeptide	JJ	JJ	_	31	amod	_	_
31	antibodies	antibody	NNS	NNS	_	28	nmod	_	_
32	generated	generate	VBN	VBN	_	31	acl	_	_
33	against	against	IN	IN	_	34	case	_	_
34	hGR	hgr	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	cell-free	cell-free	JJ	JJ	_	6	amod	_	_
5	synthesized	synthesize	VBN	VBN	_	6	amod	_	_
6	hGR	hgr	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	capable	capable	JJ	JJ	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	binding	binding	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	21	case	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	19	nmod:npmod	_	_
14	response	response	NN	NN	_	19	nmod:npmod	_	_
15	element	element	NN	NN	_	19	nmod:npmod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	GRE	gre	NN	NN	_	19	nmod:npmod	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	-containing	-containing	JJ	JJ	_	21	amod	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	fragments	fragment	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Using	use	VBG	VBG	_	8	advcl	_	_
2	this	this	DT	DT	_	4	det	_	_
3	assay	assay	NN	NN	_	4	compound	_	_
4	system	system	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	evaluated	evaluate	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	contributions	contribution	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	ligand	ligand	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	heat	heat	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	conj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	10	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	these	these	DT	DT	_	23	det	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	3	advmod	_	_
3	translated	translate	VBN	VBN	_	4	amod	_	_
4	hGR	hgr	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	selective	selective	JJ	JJ	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	binding	binding	NN	NN	_	6	nmod	_	_
11	even	even	RB	RB	_	16	advmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	dep	_	_
14	absence	absence	NN	NN	_	16	dep	_	_
15	of	of	IN	IN	_	16	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	antiglucocorticoid	antiglucocorticoid	JJ	JJ	_	7	amod	_	_
7	RU486	ru486	NN	NN	_	3	conj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	11	neg	_	_
10	additional	additional	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	capacity	capacity	NN	NN	_	8	nmod	_	_
16	when	when	WRB	WRB	_	20	advmod	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	preparations	preparation	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	maintained	maintain	VBN	VBN	_	8	advcl	_	_
21	at	at	IN	IN	_	23	case	_	_
22	0	0	CD	CD	_	23	nummod	_	_
23	C	c	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	no	no	DT	DT	_	26	neg	_	_
26	activation	activation	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	addition	addition	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	either	either	CC	CC	_	7	cc:preconj	_	_
7	ligand	ligand	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	antagonist	antagonist	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	combination	combination	NN	NN	_	4	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	heat	heat	NN	NN	_	16	compound	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	step	step	NN	NN	_	11	nmod	_	_
17	promoted	promote	VBD	VBD	_	0	root	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	17	dobj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	approximately	approximately	RB	RB	_	22	advmod	_	_
22	3-fold	3-fold	RB	RB	_	17	nmod	_	_
23	over	over	IN	IN	_	24	case	_	_
24	that	that	DT	DT	_	22	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	heat-activated	heat-activated	JJ	JJ	_	28	amod	_	_
27	unliganded	unliganded	JJ	JJ	_	28	amod	_	_
28	receptors	receptor	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	Agonist	agonist	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	dexamethasone	dexamethasone	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	was	be	VBD	VBD	_	8	cop	_	_
6	slightly	slightly	RB	RB	_	7	advmod	_	_
7	more	more	JJR	JJR	_	8	advmod	_	_
8	effective	effective	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	supporting	support	VBG	VBG	_	8	advcl	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	dobj	_	_
14	than	than	IN	IN	_	15	case	_	_
15	antagonist	antagonist	NN	NN	_	8	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	RU486	ru486	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	8	punct	_	_

1	DNA	dna	NN	NN	_	2	compound	_	_
2	binding	binding	NN	NN	_	9	nsubjpass	_	_
3	by	by	IN	IN	_	7	case	_	_
4	in	in	FW	FW	_	5	compound	_	_
5	vitro	vitro	FW	FW	_	6	advmod	_	_
6	synthesized	synthesize	VBN	VBN	_	7	amod	_	_
7	GR	gr	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	addition	addition	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	sodium	sodium	NN	NN	_	15	compound	_	_
15	molybdate	molybdate	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	preparations	preparation	NNS	NNS	_	12	nmod	_	_
20	before	before	IN	IN	_	22	case	_	_
21	steroid	steroid	NN	NN	_	22	compound	_	_
22	addition	addition	NN	NN	_	12	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	thermal	thermal	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	9	punct	_	_

1	Addition	addition	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	KCl	kcl	NN	NN	_	1	nmod	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	less	less	RBR	RBR	_	8	advmod	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	4	nmod	_	_
9	either	either	CC	CC	_	12	dep	_	_
10	due	due	JJ	JJ	_	12	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	blockage	blockage	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	DNA-receptor	dna-receptor	JJ	JJ	_	16	amod	_	_
15	complex	complex	NN	NN	_	16	compound	_	_
16	formation	formation	NN	NN	_	12	nmod	_	_
17	or	or	CC	CC	_	12	cc	_	_
18	disruption	disruption	NN	NN	_	12	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	complexes	complex	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	specificity	specificity	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	cell-free	cell-free	JJ	JJ	_	9	amod	_	_
8	synthesized	synthesize	VBN	VBN	_	9	amod	_	_
9	hGR	hgr	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	further	further	RB	RB	_	11	advmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	examining	examine	VBG	VBG	_	11	advcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	abilities	ability	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	DNAs	dna	NNS	NNS	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	compete	compete	VB	VB	_	16	acl	_	_
22	for	for	IN	IN	_	23	mark	_	_
23	binding	bind	VBG	VBG	_	21	advcl	_	_
24	to	to	TO	TO	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	naturally	naturally	RB	RB	_	27	advmod	_	_
27	occurring	occur	VBG	VBG	_	28	amod	_	_
28	GRE	gre	NN	NN	_	23	nmod	_	_
29	found	find	VBD	VBD	_	28	acl	_	_
30	in	in	IN	IN	_	37	case	_	_
31	the	the	DT	DT	_	37	det	_	_
32	mouse	mouse	NN	NN	_	36	nmod:npmod	_	_
33	mammary	mammary	JJ	JJ	_	36	amod	_	_
34	tumor	tumor	NN	NN	_	36	nmod:npmod	_	_
35	virus-long	virus-long	JJ	JJ	_	36	amod	_	_
36	terminal	terminal	JJ	JJ	_	37	amod	_	_
37	repeat	repeat	NN	NN	_	29	nmod	_	_
38	.	.	.	.	_	11	punct	_	_

1	Oligonucleotides	oligonucleotide	NNS	NNS	_	10	nsubj	_	_
2	containing	contain	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	consensus	consensus	NN	NN	_	5	compound	_	_
5	GRE	gre	NN	NN	_	2	dobj	_	_
6	were	be	VBD	VBD	_	10	cop	_	_
7	the	the	DT	DT	_	10	det	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	efficient	efficient	JJ	JJ	_	10	amod	_	_
10	competitors	competitor	NNS	NNS	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	fragments	fragment	NNS	NNS	_	22	nsubj	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	sequences	sequence	NNS	NNS	_	14	dobj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	glucocorticoid-repressible	glucocorticoid-repressible	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	were	be	VBD	VBD	_	22	cop	_	_
21	somewhat	somewhat	RB	RB	_	22	advmod	_	_
22	competitive	competitive	JJ	JJ	_	10	conj	_	_
23	,	,	,	,	_	10	punct	_	_
24	whereas	whereas	IN	IN	_	10	dep	_	_
25	single	single	JJ	JJ	_	26	amod	_	_
26	stranded	stranded	JJ	JJ	_	27	amod	_	_
27	oligonucleotides	oligonucleotide	NNS	NNS	_	29	nsubj	_	_
28	were	be	VBD	VBD	_	29	cop	_	_
29	unable	unable	JJ	JJ	_	10	parataxis	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	compete	compete	VB	VB	_	29	xcomp	_	_
32	for	for	IN	IN	_	40	case	_	_
33	mouse	mouse	NN	NN	_	38	nmod:npmod	_	_
34	mammary	mammary	JJ	JJ	_	38	amod	_	_
35	tumor	tumor	NN	NN	_	38	nmod:npmod	_	_
36	virus-long	virus-long	JJ	JJ	_	38	amod	_	_
37	terminal	terminal	JJ	JJ	_	38	amod	_	_
38	repeat	repeat	NN	NN	_	40	amod	_	_
39	DNA	dna	NN	NN	_	40	compound	_	_
40	binding	binding	NN	NN	_	31	nmod	_	_
41	,	,	,	,	_	29	punct	_	_
42	except	except	IN	IN	_	46	mark	_	_
43	when	when	WRB	WRB	_	46	advmod	_	_
44	competitor	competitor	NN	NN	_	46	nsubj	_	_
45	was	be	VBD	VBD	_	46	cop	_	_
46	present	present	JJ	JJ	_	29	advcl	_	_
47	at	at	IN	IN	_	50	case	_	_
48	extremely	extremely	RB	RB	_	49	advmod	_	_
49	high	high	JJ	JJ	_	50	amod	_	_
50	concentrations	concentration	NNS	NNS	_	46	nmod	_	_
51	.	.	.	.	_	10	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	indicate	indicate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	hGR	hgr	NN	NN	_	12	nsubj	_	_
7	synthesized	synthesize	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	rabbit	rabbit	NN	NN	_	11	compound	_	_
10	reticulocyte	reticulocyte	NN	NN	_	11	compound	_	_
11	lysates	lysate	NNS	NNS	_	7	nmod	_	_
12	displays	display	VBZ	VBZ	_	4	ccomp	_	_
13	many	many	JJ	JJ	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	same	same	JJ	JJ	_	17	amod	_	_
17	properties	property	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	including	include	VBG	VBG	_	22	case	_	_
20	GRE-specific	gre-specific	JJ	JJ	_	22	amod	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	17	punct	_	_
24	observed	observe	VBN	VBN	_	17	acl	_	_
25	for	for	IN	IN	_	27	case	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	24	nmod	_	_
28	present	present	JJ	JJ	_	27	amod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	cytosolic	cytosolic	JJ	JJ	_	31	amod	_	_
31	extracts	extract	NNS	NNS	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	mammalian	mammalian	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	tissues	tissue	NNS	NNS	_	34	conj	_	_
37	.	.	.	.	_	4	punct	_	_

1	Similarities	similarity	NNS	NNS	_	9	nsubj	_	_
2	between	between	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	dexamethasone	dexamethasone	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	RU486	ru486	NN	NN	_	6	conj	_	_
9	suggest	suggest	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	antiglucocorticoid	antiglucocorticoid	JJ	JJ	_	13	amod	_	_
13	properties	property	NNS	NNS	_	18	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	RU486	ru486	NN	NN	_	13	nmod	_	_
16	do	do	VBP	VBP	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	occur	occur	VB	VB	_	9	ccomp	_	_
19	at	at	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	level	level	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	binding	binding	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	One	one	CD	CD	_	4	nummod	_	_
2	base	base	NN	NN	_	4	compound	_	_
3	pair	pair	NN	NN	_	4	compound	_	_
4	change	change	NN	NN	_	5	nsubj	_	_
5	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	T	t	NN	NN	_	8	nmod:npmod	_	_
8	cell-restricted	cell-restricted	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	kB-like	kb-like	JJ	JJ	_	14	amod	_	_
13	proto-enhancer	proto-enhancer	NN	NN	_	14	compound	_	_
14	element	element	NN	NN	_	9	nmod	_	_
15	from	from	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	interleukin	interleukin	NN	NN	_	19	compound	_	_
18	2	2	CD	CD	_	19	nummod	_	_
19	promoter	promoter	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	inducible	inducible	JJ	JJ	_	6	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	T	t	NN	NN	_	5	nmod:npmod	_	_
5	cell-specific	cell-specific	JJ	JJ	_	2	dep	_	_
6	enhancers	enhancer	NNS	NNS	_	17	nsubj	_	_
7	of	of	IN	IN	_	16	case	_	_
8	murine	murine	JJ	JJ	_	16	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	human	human	JJ	JJ	_	8	conj	_	_
11	Interleukin	interleukin	NN	NN	_	16	compound	_	_
12	2	2	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	Il-2	il-2	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	genes	gene	NNS	NNS	_	6	nmod	_	_
17	contain	contain	VBP	VBP	_	0	root	_	_
18	the	the	DT	DT	_	21	det	_	_
19	kB-like	kb-like	JJ	JJ	_	21	amod	_	_
20	sequence	sequence	NN	NN	_	21	compound	_	_
21	GGGATTTCACC	gggatttcacc	NN	NN	_	17	dobj	_	_
22	as	as	IN	IN	_	27	case	_	_
23	an	a	DT	DT	_	27	det	_	_
24	essential	essential	JJ	JJ	_	27	amod	_	_
25	cis-acting	cis-acting	JJ	JJ	_	27	amod	_	_
26	enhancer	enhancer	NN	NN	_	27	compound	_	_
27	motif	motif	NN	NN	_	17	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	cloned	clone	VBN	VBN	_	15	advcl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	multiple	multiple	JJ	JJ	_	5	amod	_	_
5	copies	copy	NNS	NNS	_	2	nmod	_	_
6	this	this	DT	DT	_	8	det	_	_
7	so-called	so-called	JJ	JJ	_	8	amod	_	_
8	TCEd	tced	NN	NN	_	15	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	distal	distal	JJ	JJ	_	13	amod	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	8	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	acts	act	VBZ	VBZ	_	0	root	_	_
16	as	as	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	inducible	inducible	JJ	JJ	_	20	amod	_	_
19	proto-enhancer	proto-enhancer	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	15	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	E14	e14	NN	NN	_	25	compound	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	lymphoma	lymphoma	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	15	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	but	but	CC	CC	_	25	cc	_	_
28	not	not	RB	RB	_	31	neg	_	_
29	in	in	IN	IN	_	31	case	_	_
30	HeLa	hela	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	conj	_	_
32	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	extracts	extract	NNS	NNS	_	14	nmod	_	_
3	of	of	IN	IN	_	9	case	_	_
4	induced	induce	VBN	VBN	_	9	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	Il-2	il-2	NN	NN	_	7	dep	_	_
7	secreting	secreting	NN	NN	_	4	dep	_	_
8	El4	el4	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	three	three	CD	CD	_	13	nummod	_	_
11	individual	individual	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	14	nsubj	_	_
14	bind	bind	VBP	VBP	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	TCEd	tced	NN	NN	_	17	compound	_	_
17	DNA	dna	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	most	most	RBS	RBS	_	6	advmod	_	_
6	prominent	prominent	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	named	name	VBN	VBN	_	7	acl	_	_
10	TCF-1	tcf-1	NN	NN	_	9	xcomp	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	10	appos	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	)	)	-RRB-	-RRB-	_	14	punct	_	_
17	,	,	,	,	_	7	punct	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	correlated	correlate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	proto-enhancer	proto-enhancer	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	TCEd	tced	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	nsubj	_	_
2	consists	consist	VBZ	VBZ	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	polypeptides	polypeptide	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	about	about	RB	RB	_	9	advmod	_	_
8	50	50	CD	CD	_	9	nummod	_	_
9	kD	kd	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	105	105	CD	CD	_	12	nummod	_	_
12	kD	kd	NN	NN	_	9	conj	_	_
13	;	;	:	:	_	2	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	former	former	JJ	JJ	_	16	nsubj	_	_
16	seems	seem	VBZ	VBZ	_	2	parataxis	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	related	related	JJ	JJ	_	16	xcomp	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	50	50	CD	CD	_	23	nummod	_	_
23	kD	kd	NN	NN	_	19	nmod	_	_
24	polypeptide	polypeptide	NN	NN	_	23	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	NF-kB	nf-kb	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Purified	purify	VBN	VBN	_	2	amod	_	_
2	NF-kB	nf-kb	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	bind	bind	VB	VB	_	5	xcomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	TCEd	tced	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	but	but	CC	CC	_	5	cc	_	_
13	TCF-1	tcf-1	NN	NN	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	5	conj	_	_
15	stronger	stronger	JJR	JJR	_	14	advmod	_	_
16	than	than	IN	IN	_	17	case	_	_
17	NF-kB	nf-kb	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	TCEd	tced	NN	NN	_	20	compound	_	_
20	DNA	dna	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	conversion	conversion	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	TCEd	tced	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	13	case	_	_
7	a	a	DT	DT	_	13	det	_	_
8	'	'	``	``	_	13	punct	_	_
9	perfect	perfect	JJ	JJ	_	13	amod	_	_
10	'	'	''	''	_	13	punct	_	_
11	NF-kB	nf-kb	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	2	nmod	_	_
14	leads	lead	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	tighter	tighter	JJR	JJR	_	18	amod	_	_
18	binding	binding	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	NF-kB	nf-kb	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	TCEd	tced	NN	NN	_	23	compound	_	_
23	DNA	dna	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	,	,	,	,	_	14	punct	_	_
26	as	as	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	functional	functional	JJ	JJ	_	29	amod	_	_
29	consequence	consequence	NN	NN	_	14	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	to	to	TO	TO	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	activity	activity	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	40	case	_	_
35	the	the	DT	DT	_	40	det	_	_
36	'	'	``	``	_	40	punct	_	_
37	converted	convert	VBN	VBN	_	40	amod	_	_
38	'	'	''	''	_	40	punct	_	_
39	TCEd	tced	NN	NN	_	40	compound	_	_
40	motifs	motif	NNS	NNS	_	33	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	HeLa	hela	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	33	nmod	_	_
44	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	substitution	substitution	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	underlined	underline	VBN	VBN	_	9	amod	_	_
8	A	a	NN	NN	_	9	compound	_	_
9	residue	residue	NN	NN	_	4	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	C	c	NN	NN	_	4	nmod	_	_
13	within	within	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	GGGATTTCACC	gggatttcacc	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	4	nmod	_	_
17	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
18	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
19	T	t	NN	NN	_	20	nmod:npmod	_	_
20	cell-restricted	cell-restricted	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	17	dobj	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	leads	lead	VBZ	VBZ	_	17	conj	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	its	its	PRP$	PRP$	_	26	nsubj	_	_
26	functioning	function	VBG	VBG	_	23	advcl	_	_
27	in	in	IN	IN	_	30	case	_	_
28	both	both	CC	CC	_	30	cc:preconj	_	_
29	El4	el4	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	HeLa	hela	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	conj	_	_
34	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	12	nsubjpass	_	_
7	binding	bind	VBG	VBG	_	6	acl	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	TCEd	tced	NN	NN	_	7	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	control	control	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	specific-transcription	specific-transcription	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	Il-2	il-2	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Negative	negative	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
6	virus	virus	NN	NN	_	9	compound	_	_
7	type	type	NN	NN	_	9	compound	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	expression	expression	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	role	role	NN	NN	_	2	dep	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	65-kDa	65-kda	JJ	JJ	_	21	amod	_	_
17	plus	plus	CC	CC	_	16	cc	_	_
18	50-kDa	50-kda	JJ	JJ	_	16	conj	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	dimer	dimer	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	monocytic	monocytic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	provide	provide	VB	VB	_	29	advcl	_	_
6	a	a	DT	DT	_	7	det	_	_
7	reservoir	reservoir	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	production	production	NN	NN	_	7	nmod	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	5	advmod	_	_
13	,	,	,	,	_	29	punct	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	regulation	regulation	NN	NN	_	29	nsubj	_	_
16	of	of	IN	IN	_	25	case	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	20	compound	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	type	type	NN	NN	_	25	compound	_	_
21	1	1	CD	CD	_	20	nummod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	HIV-1	hiv-1	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	transcription	transcription	NN	NN	_	15	nmod	_	_
26	can	can	MD	MD	_	29	aux	_	_
27	be	be	VB	VB	_	29	cop	_	_
28	either	either	CC	CC	_	29	cc:preconj	_	_
29	latent	latent	JJ	JJ	_	0	root	_	_
30	,	,	,	,	_	29	punct	_	_
31	restricted	restricted	JJ	JJ	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	or	or	CC	CC	_	29	cc	_	_
34	productive	productive	JJ	JJ	_	29	conj	_	_
35	.	.	.	.	_	29	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	10	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	have	have	VBP	VBP	_	10	aux	_	_
7	not	not	RB	RB	_	10	neg	_	_
8	been	be	VBN	VBN	_	10	auxpass	_	_
9	molecularly	molecularly	RB	RB	_	10	advmod	_	_
10	defined	define	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	THP-1	thp-1	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	restricted	restricted	JJ	JJ	_	7	amod	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	there	there	EX	EX	_	10	expl	_	_
10	is	be	VBZ	VBZ	_	0	root	_	_
11	an	a	DT	DT	_	12	det	_	_
12	absence	absence	NN	NN	_	10	nsubj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	DNA-protein	dna-protein	JJ	JJ	_	17	amod	_	_
15	binding	binding	NN	NN	_	17	compound	_	_
16	complex	complex	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	12	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
21	promoter-enhancer	promoter-enhancer	NN	NN	_	17	nmod	_	_
22	associated	associate	VBN	VBN	_	21	acl	_	_
23	with	with	IN	IN	_	28	case	_	_
24	markedly	markedly	RB	RB	_	25	advmod	_	_
25	less	less	JJR	JJR	_	26	advmod	_	_
26	viral	viral	JJ	JJ	_	28	amod	_	_
27	RNA	rna	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	binding	binding	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	11	nmod	_	_
16	;	;	:	:	_	6	punct	_	_
17	the	the	DT	DT	_	23	det	_	_
18	65-kDa	65-kda	JJ	JJ	_	23	amod	_	_
19	plus	plus	CC	CC	_	18	cc	_	_
20	50-kDa	50-kda	JJ	JJ	_	18	conj	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	heterodimer	heterodimer	NN	NN	_	26	nsubjpass	_	_
24	was	be	VBD	VBD	_	26	auxpass	_	_
25	preferentially	preferentially	RB	RB	_	26	advmod	_	_
26	lost	lose	VBN	VBN	_	6	parataxis	_	_
27	.	.	.	.	_	26	punct	_	_

1	Adding	add	VBG	VBG	_	14	csubj	_	_
2	purified	purify	VBN	VBN	_	5	amod	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	extracts	extract	NNS	NNS	_	1	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	cells	cell	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	restricted	restricted	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	overcomes	overcome	VBZ	VBZ	_	0	root	_	_
15	this	this	DT	DT	_	16	det	_	_
16	lack	lack	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	binding	binding	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	treatment	treatment	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	extracts	extract	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	deoxycholate	deoxycholate	NN	NN	_	4	nmod	_	_
12	restored	restore	VBD	VBD	_	0	root	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	form	form	VB	VB	_	14	acl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	heterodimer	heterodimer	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	12	punct	_	_
20	suggesting	suggest	VBG	VBG	_	12	advcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	presence	presence	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	an	a	DT	DT	_	25	det	_	_
25	inhibitor	inhibitor	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	treatment	treatment	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	had	have	VBD	VBD	_	6	acl:relcl	_	_
12	restricted	restricted	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	with	with	IN	IN	_	15	case	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	3	nmod	_	_
16	increased	increase	VBD	VBD	_	0	root	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	production	production	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	16	punct	_	_

1	Antiserum	antiserum	NN	NN	_	14	nsubj	_	_
2	specific	specific	JJ	JJ	_	1	amod	_	_
3	for	for	IN	IN	_	7	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	2	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	1	cc	_	_
11	c-rel-specific	c-rel-specific	JJ	JJ	_	12	amod	_	_
12	antiserum	antiserum	NN	NN	_	1	conj	_	_
13	,	,	,	,	_	1	punct	_	_
14	disrupted	disrupt	VBD	VBD	_	0	root	_	_
15	heterodimer	heterodimer	NN	NN	_	17	compound	_	_
16	complex	complex	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	both	both	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	nmod:npmod	_	_
5	B-binding	b-binding	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	needed	need	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	12	case	_	_
10	optimal	optimal	JJ	JJ	_	12	amod	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	transcription	transcription	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Binding	binding	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	65-kDa	65-kda	JJ	JJ	_	7	amod	_	_
5	plus	plus	CC	CC	_	4	cc	_	_
6	50-kDa	50-kda	JJ	JJ	_	4	conj	_	_
7	heterodimer	heterodimer	NN	NN	_	1	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	1	nmod	_	_
12	can	can	MD	MD	_	15	aux	_	_
13	be	be	VB	VB	_	15	auxpass	_	_
14	negatively	negatively	RB	RB	_	15	advmod	_	_
15	regulated	regulate	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	providing	provide	VBG	VBG	_	15	xcomp	_	_
20	one	one	CD	CD	_	21	nummod	_	_
21	mechanism	mechanism	NN	NN	_	19	dobj	_	_
22	restricting	restrict	VBG	VBG	_	21	acl	_	_
23	HIV-1	hiv-1	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	15	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	candidate	candidate	NN	NN	_	1	nmod	_	_
5	repressor/activator	repressor/activator	NN	NN	_	4	dep	_	_
6	,	,	,	,	_	4	punct	_	_
7	NF-E1	nf-e1	NN	NN	_	4	appos	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	YY-1	yy-1	NN	NN	_	11	compound	_	_
10	,	,	,	,	_	11	punct	_	_
11	delta	delta	NN	NN	_	7	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	4	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	binds	bind	VBZ	VBZ	_	4	acl:relcl	_	_
16	to	to	TO	TO	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	immunoglobulin	immunoglobulin	NN	NN	_	21	compound	_	_
19	kappa	kappa	NN	NN	_	21	compound	_	_
20	3'	3'	JJ	JJ	_	21	amod	_	_
21	enhancer	enhancer	NN	NN	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	28	det	_	_
24	immunoglobulin	immunoglobulin	NN	NN	_	28	compound	_	_
25	heavy-chain	heavy-chain	NN	NN	_	28	compound	_	_
26	mu	mu	NN	NN	_	28	compound	_	_
27	E1	e1	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	developmental	developmental	JJ	JJ	_	7	amod	_	_
7	control	control	NN	NN	_	20	nsubj	_	_
8	of	of	IN	IN	_	17	case	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	17	compound	_	_
10	kappa	kappa	NN	NN	_	17	compound	_	_
11	3'	3'	JJ	JJ	_	17	amod	_	_
12	enhancer	enhancer	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	kappa	kappa	NN	NN	_	17	compound	_	_
15	E3'	e3'	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	activity	activity	NN	NN	_	7	nmod	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	the	the	DT	DT	_	20	det	_	_
20	result	result	NN	NN	_	3	ccomp	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	combined	combined	JJ	JJ	_	24	amod	_	_
24	influence	influence	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	positive-	positive-	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	negative-acting	negative-acting	JJ	JJ	_	26	conj	_	_
29	elements	element	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	a	a	DT	DT	_	6	det	_	_
5	central	central	JJ	JJ	_	6	amod	_	_
6	core	core	NN	NN	_	13	nsubj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	E3'	e3'	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	active	active	JJ	JJ	_	2	ccomp	_	_
14	at	at	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	pre-B-cell	pre-b-cell	JJ	JJ	_	17	amod	_	_
17	stage	stage	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	repressed	repress	VBN	VBN	_	13	conj	_	_
21	by	by	IN	IN	_	24	case	_	_
22	flanking	flank	VBG	VBG	_	24	amod	_	_
23	negative-acting	negative-acting	JJ	JJ	_	24	amod	_	_
24	elements	element	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	negative-acting	negative-acting	JJ	JJ	_	3	amod	_	_
3	sequences	sequence	NNS	NNS	_	4	nsubj	_	_
4	repress	repress	VBP	VBP	_	0	root	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	position-	position-	NN	NN	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	orientation-independent	orientation-independent	JJ	JJ	_	9	conj	_	_
12	manner	manner	NN	NN	_	4	nmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	pre-B-cell	pre-b-cell	JJ	JJ	_	16	amod	_	_
16	stage	stage	NN	NN	_	4	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	clone	clone	NN	NN	_	3	dobj	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	zinc	zinc	NN	NN	_	12	compound	_	_
11	finger	finger	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NF-E1	nf-e1	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	binds	bind	VBZ	VBZ	_	12	acl:relcl	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	negative-acting	negative-acting	JJ	JJ	_	21	amod	_	_
21	segment	segment	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	kappa	kappa	NN	NN	_	26	compound	_	_
25	E3'	e3'	NN	NN	_	26	compound	_	_
26	enhancer	enhancer	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	immunoglobulin	immunoglobulin	NN	NN	_	12	compound	_	_
8	heavy-chain	heavy-chain	NN	NN	_	12	compound	_	_
9	enhancer	enhancer	NN	NN	_	12	compound	_	_
10	mu	mu	NN	NN	_	12	compound	_	_
11	E1	e1	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	NF-E1	nf-e1	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	encoded	encode	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	same	same	JJ	JJ	_	7	amod	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	as	as	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	YY-1	yy-1	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
15	to	to	TO	TO	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	adeno-associated	adeno-associated	JJ	JJ	_	20	amod	_	_
18	virus	virus	NN	NN	_	20	compound	_	_
19	P5	p5	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	NF-E1	nf-e1	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	also	also	RB	RB	_	6	advmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	homologue	homologue	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	mouse	mouse	NN	NN	_	11	compound	_	_
10	delta	delta	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	6	acl:relcl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	ribosomal	ribosomal	JJ	JJ	_	19	amod	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	promoters	promoter	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	predicted	predict	VBN	VBN	_	5	amod	_	_
3	amino	amino	NN	NN	_	5	compound	_	_
4	acid	acid	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	contains	contain	VBZ	VBZ	_	0	root	_	_
10	features	feature	NNS	NNS	_	9	dobj	_	_
11	characteristic	characteristic	JJ	JJ	_	10	amod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activators	activator	NNS	NNS	_	11	nmod	_	_
15	as	as	RB	RB	_	14	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	repressors	repressor	NNS	NNS	_	14	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	6	nsubj	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	cDNA	cdna	NN	NN	_	2	nmod	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	it	it	PRP	PRP	_	10	nsubj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	repress	repress	VB	VB	_	6	ccomp	_	_
11	basal	basal	JJ	JJ	_	13	amod	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	apparent	apparent	JJ	JJ	_	4	amod	_	_
3	dual	dual	JJ	JJ	_	4	amod	_	_
4	function	function	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	protein	protein	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	discussed	discuss	VBN	VBN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	Clone	clone	NN	NN	_	2	compound	_	_
2	pAT	pat	NN	NN	_	4	nsubj	_	_
3	133	133	CD	CD	_	2	nummod	_	_
4	identifies	identify	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	gene	gene	NN	NN	_	4	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	encodes	encode	VBZ	VBZ	_	6	acl:relcl	_	_
9	another	another	DT	DT	_	11	det	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	member	member	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	class	class	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	growth	growth	NN	NN	_	17	nmod:npmod	_	_
17	factor-induced	factor-induced	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	14	nmod	_	_
19	with	with	IN	IN	_	23	case	_	_
20	almost	almost	RB	RB	_	21	advmod	_	_
21	identical	identical	JJ	JJ	_	23	amod	_	_
22	zinc-finger	zinc-finger	NN	NN	_	23	compound	_	_
23	domains	domain	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	structure	structure	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	regulation	regulation	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	represented	represent	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	clone	clone	NN	NN	_	13	compound	_	_
13	pAT	pat	NN	NN	_	10	nmod	_	_
14	133	133	CD	CD	_	13	nummod	_	_
15	,	,	,	,	_	13	punct	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	induced	induce	VBN	VBN	_	13	acl:relcl	_	_
19	upon	upon	IN	IN	_	20	case	_	_
20	transition	transition	NN	NN	_	18	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	resting	resting	JJ	JJ	_	24	amod	_	_
24	state	state	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	G0	g0	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	through	through	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	early	early	JJ	JJ	_	31	amod	_	_
31	phase	phase	NN	NN	_	20	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	cycle	cycle	NN	NN	_	31	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	G1	g1	NN	NN	_	31	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	pAT	pat	NN	NN	_	4	compound	_	_
3	133	133	CD	CD	_	4	nummod	_	_
4	gene	gene	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	immediately	immediately	RB	RB	_	7	advmod	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	with	with	IN	IN	_	11	case	_	_
10	FOS-like	fos-like	JJ	JJ	_	11	amod	_	_
11	kinetics	kinetics	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	in	in	IN	IN	_	19	case	_	_
19	fibroblasts	fibroblast	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Primary	primary	JJ	JJ	_	3	amod	_	_
2	structure	structure	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	encoded	encode	VBN	VBN	_	8	amod	_	_
8	protein	protein	NN	NN	_	9	nsubj	_	_
9	contains	contain	VBZ	VBZ	_	4	ccomp	_	_
10	three	three	CD	CD	_	13	nummod	_	_
11	tandem	tandem	JJ	JJ	_	13	amod	_	_
12	zinc-finger	zinc-finger	NN	NN	_	13	compound	_	_
13	sequences	sequence	NNS	NNS	_	9	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	type	type	NN	NN	_	17	compound	_	_
17	Cys2-Xaa12-His2	cys2-xaa12-his2	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	zinc-finger	zinc-finger	NN	NN	_	3	compound	_	_
3	region	region	NN	NN	_	17	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	thought	think	VBN	VBN	_	3	acl:relcl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	bind	bind	VB	VB	_	7	xcomp	_	_
10	DNA	dna	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	sequence-specific	sequence-specific	JJ	JJ	_	14	amod	_	_
14	manner	manner	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	similar	similar	JJ	JJ	_	0	root	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	greater	greater	JJR	JJR	_	21	advmod	_	_
20	than	than	IN	IN	_	21	advmod	_	_
21	80	80	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	17	dep	_	_
23	on	on	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	amino	amino	NN	NN	_	27	compound	_	_
26	acid	acid	NN	NN	_	27	compound	_	_
27	level	level	NN	NN	_	22	nmod	_	_
28	)	)	-RRB-	-RRB-	_	22	punct	_	_
29	to	to	TO	TO	_	34	case	_	_
30	two	two	CD	CD	_	34	nummod	_	_
31	previously	previously	RB	RB	_	32	advmod	_	_
32	described	describe	VBN	VBN	_	34	amod	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	17	nmod	_	_
35	pAT	pat	NN	NN	_	36	compound	_	_
36	225/EGR1	225/egr1	NN	NN	_	34	dep	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	pAT	pat	NN	NN	_	39	compound	_	_
39	591/EGR2	591/egr2	NN	NN	_	36	conj	_	_
40	.	.	.	.	_	17	punct	_	_

1	Except	except	IN	IN	_	6	case	_	_
2	for	for	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	conserved	conserve	VBN	VBN	_	6	amod	_	_
5	zinc-finger	zinc-finger	NN	NN	_	6	compound	_	_
6	domains	domain	NNS	NNS	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	amino	amino	NN	NN	_	11	compound	_	_
10	acid	acid	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	17	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	three	three	CD	CD	_	15	nummod	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	distinct	distinct	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	structural	structural	JJ	JJ	_	3	amod	_	_
3	similarity	similarity	NN	NN	_	4	nsubj	_	_
4	suggests	suggest	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	pAT	pat	NN	NN	_	9	compound	_	_
8	133	133	CD	CD	_	9	nummod	_	_
9	gene	gene	NN	NN	_	10	nsubj	_	_
10	encodes	encode	VBZ	VBZ	_	4	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	10	dobj	_	_
14	with	with	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	biological	biological	JJ	JJ	_	18	amod	_	_
18	function	function	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Comparing	compare	VBG	VBG	_	9	csubj	_	_
2	the	the	DT	DT	_	3	det	_	_
3	regulation	regulation	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	these	these	DT	DT	_	8	det	_	_
6	related	related	JJ	JJ	_	8	amod	_	_
7	zinc-finger-encoding	zinc-finger-encoding	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	3	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	coordinate	coordinate	JJ	JJ	_	11	amod	_	_
11	induction	induction	NN	NN	_	9	dobj	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	mitogenic	mitogenic	JJ	JJ	_	14	amod	_	_
14	stimulation	stimulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	resting	rest	VBG	VBG	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	of	of	IN	IN	_	22	case	_	_
21	resting	rest	VBG	VBG	_	22	amod	_	_
22	fibroblasts	fibroblast	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	upon	upon	IN	IN	_	4	case	_	_
4	transition	transition	NN	NN	_	24	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	proliferating	proliferating	JJ	JJ	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	G1	g1	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	to	to	TO	TO	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	resting	resting	JJ	JJ	_	4	nmod	_	_
14	state	state	NN	NN	_	4	dep	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	cycle	cycle	NN	NN	_	4	nmod	_	_
19	the	the	DT	DT	_	21	det	_	_
20	three	three	CD	CD	_	21	nummod	_	_
21	genes	gene	NNS	NNS	_	24	nsubjpass	_	_
22	were	be	VBD	VBD	_	24	auxpass	_	_
23	differently	differently	RB	RB	_	24	advmod	_	_
24	regulated	regulate	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	histiocytic	histiocytic	JJ	JJ	_	5	amod	_	_
4	U937	u937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	13	nmod	_	_
6	mRNA	mrna	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	clone	clone	NN	NN	_	9	compound	_	_
9	pAT	pat	NN	NN	_	6	nmod	_	_
10	133	133	CD	CD	_	9	nummod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	constitutively	constitutively	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	whereas	whereas	IN	IN	_	13	dep	_	_
16	mRNA	mrna	NN	NN	_	21	nsubjpass	_	_
17	of	of	IN	IN	_	19	case	_	_
18	pAT	pat	NN	NN	_	19	compound	_	_
19	225/EGR1	225/egr1	NN	NN	_	16	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	13	parataxis	_	_
22	upon	upon	IN	IN	_	23	case	_	_
23	induction	induction	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	terminal	terminal	JJ	JJ	_	26	amod	_	_
26	differentiation	differentiation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	mRNA	mrna	NN	NN	_	9	nsubjpass	_	_
4	representing	represent	VBG	VBG	_	3	acl	_	_
5	pAT	pat	NN	NN	_	6	compound	_	_
6	591/EGR2	591/egr2	NN	NN	_	4	dobj	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	regulation	regulation	NN	NN	_	2	nmod	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	distinct	distinct	JJ	JJ	_	9	amod	_	_
8	biological	biological	JJ	JJ	_	9	amod	_	_
9	roles	role	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	control	control	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	12	nmod	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	respective	respective	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	cAMP-dependent	camp-dependent	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	proenkephalin	proenkephalin	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	JunD	jund	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	JunB	junb	NN	NN	_	6	conj	_	_
9	:	:	:	:	_	2	punct	_	_
10	positive	positive	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	negative	negative	JJ	JJ	_	10	conj	_	_
13	effects	effect	NNS	NNS	_	2	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	JunD	jund	NN	NN	_	15	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	component	component	NN	NN	_	4	appos	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	AP-1	ap-1	NN	NN	_	13	compound	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
16	transcription	transcription	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	proenkephalin	proenkephalin	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	fashion	fashion	NN	NN	_	15	nmod	_	_
25	that	that	WDT	WDT	_	28	nsubj	_	_
26	is	be	VBZ	VBZ	_	28	cop	_	_
27	completely	completely	RB	RB	_	28	advmod	_	_
28	dependent	dependent	JJ	JJ	_	24	acl:relcl	_	_
29	upon	upon	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	cAMP-dependent	camp-dependent	JJ	JJ	_	33	amod	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	kinase	kinase	NN	NN	_	28	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	protein	protein	NN	NN	_	37	compound	_	_
36	kinase	kinase	NN	NN	_	37	compound	_	_
37	A	a	NN	NN	_	33	appos	_	_
38	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	proenkephalin	proenkephalin	NN	NN	_	4	compound	_	_
4	transcription	transcription	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	JunD	jund	NN	NN	_	1	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	upon	upon	IN	IN	_	20	case	_	_
10	a	a	DT	DT	_	20	det	_	_
11	previously	previously	RB	RB	_	12	advmod	_	_
12	characterized	characterize	VBN	VBN	_	20	amod	_	_
13	cAMP-	camp-	NN	NN	_	20	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester-	ester-	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	Ca(2+)-inducible	ca(2+)-inducible	JJ	JJ	_	13	conj	_	_
20	enhancer	enhancer	NN	NN	_	8	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	JunD	jund	NN	NN	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	shown	show	VBN	VBN	_	8	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	bind	bind	VB	VB	_	25	xcomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	enhancer	enhancer	NN	NN	_	27	dobj	_	_
30	as	as	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	homodimer	homodimer	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	Another	another	DT	DT	_	2	det	_	_
2	component	component	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	AP-1	ap-1	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	JunB	junb	NN	NN	_	2	appos	_	_
10	,	,	,	,	_	2	punct	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	inhibit	inhibit	VB	VB	_	12	xcomp	_	_
15	activation	activation	NN	NN	_	14	dobj	_	_
16	mediated	mediate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	JunD	jund	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	homodimer	homodimer	NN	NN	_	6	nmod	_	_
4	JunB	junb	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	unable	unable	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	bind	bind	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	enhancer	enhancer	NN	NN	_	8	dobj	_	_
11	;	;	:	:	_	6	punct	_	_
12	however	however	RB	RB	_	6	advmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	dep	_	_
15	presence	presence	NN	NN	_	17	dep	_	_
16	of	of	IN	IN	_	17	case	_	_
17	c-Fos	c-fos	NN	NN	_	22	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	high-affinity	high-affinity	JJ	JJ	_	20	amod	_	_
20	binding	binding	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	observed	observe	VBN	VBN	_	6	dep	_	_
23	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	JunD	jund	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	5	xcomp	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	genes	gene	NNS	NNS	_	8	nmod	_	_
11	linked	link	VBN	VBN	_	10	acl	_	_
12	to	to	TO	TO	_	19	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	cAMP	camp	NN	NN	_	19	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	phorbol	phorbol	NN	NN	_	17	compound	_	_
17	ester	ester	NN	NN	_	14	conj	_	_
18	response	response	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	11	nmod	_	_
20	in	in	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	protein	protein	NN	NN	_	24	nmod:npmod	_	_
23	kinase	kinase	NN	NN	_	24	nmod:npmod	_	_
24	A-dependent	a-dependent	JJ	JJ	_	25	amod	_	_
25	fashion	fashion	NN	NN	_	7	nmod	_	_
26	,	,	,	,	_	7	punct	_	_
27	further	further	RB	RB	_	28	advmod	_	_
28	blurring	blur	VBG	VBG	_	7	advcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	distinction	distinction	NN	NN	_	28	dobj	_	_
31	between	between	IN	IN	_	34	case	_	_
32	these	these	DT	DT	_	34	det	_	_
33	response	response	NN	NN	_	34	compound	_	_
34	elements	element	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	AP-1-related	ap-1-related	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	cAMP-dependent	camp-dependent	JJ	JJ	_	18	amod	_	_
17	second-messenger	second-messenger	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	JunD	jund	NN	NN	_	28	nsubj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	other	other	JJ	JJ	_	26	amod	_	_
25	AP-1-related	ap-1-related	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	22	conj	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	play	play	VB	VB	_	20	ccomp	_	_
29	an	a	DT	DT	_	31	det	_	_
30	important	important	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	regulation	regulation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	34	nmod	_	_
38	by	by	IN	IN	_	42	case	_	_
39	cAMP-dependent	camp-dependent	JJ	JJ	_	42	amod	_	_
40	intracellular	intracellular	JJ	JJ	_	42	amod	_	_
41	signaling	signaling	NN	NN	_	42	compound	_	_
42	pathways	pathway	NNS	NNS	_	34	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	resistance	resistance	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	chronic	chronic	JJ	JJ	_	5	amod	_	_
5	asthma	asthma	NN	NN	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	pharmacokinetics	pharmacokinetic	NNS	NNS	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	characteristics	characteristic	NNS	NNS	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	inhibition	inhibition	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
12	blood	blood	NN	NN	_	15	compound	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	9	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	glucocorticoids	glucocorticoid	NNS	NNS	_	9	nmod	_	_
18	in	in	FW	FW	_	9	amod	_	_
19	vitro	vitro	FW	FW	_	18	dep	_	_
20	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	total	total	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	37	37	CD	CD	_	11	nummod	_	_
5	chronic	chronic	JJ	JJ	_	11	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	severe	severe	JJ	JJ	_	5	dep	_	_
8	,	,	,	,	_	5	punct	_	_
9	nonsmoking	nonsmoking	JJ	JJ	_	5	dep	_	_
10	asthmatic	asthmatic	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	2	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	documented	documented	JJ	JJ	_	16	amod	_	_
14	reversible	reversible	JJ	JJ	_	16	amod	_	_
15	airways	airway	NNS	NNS	_	16	compound	_	_
16	obstruction	obstruction	NN	NN	_	11	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	classified	classify	VBN	VBN	_	0	root	_	_
19	as	as	IN	IN	_	20	case	_	_
20	glucocorticoid-sensitive	glucocorticoid-sensitive	JJ	JJ	_	18	advcl	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	-resistant	-resistant	JJ	JJ	_	20	conj	_	_
23	on	on	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	dep	_	_
25	basis	basis	NN	NN	_	27	dep	_	_
26	of	of	IN	IN	_	27	case	_	_
27	changes	change	NNS	NNS	_	18	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	FEV1	fev1	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	FVC	fvc	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	peak	peak	JJ	JJ	_	36	amod	_	_
35	expiratory	expiratory	NN	NN	_	36	compound	_	_
36	flow	flow	NN	NN	_	29	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	PEF	pef	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	after	after	IN	IN	_	42	case	_	_
41	oral	oral	JJ	JJ	_	42	amod	_	_
42	prednisolone	prednisolone	NN	NN	_	27	nmod	_	_
43	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	resistant	resistant	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	no	no	DT	DT	_	7	neg	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	improvements	improvement	NNS	NNS	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	airflow	airflow	NN	NN	_	10	compound	_	_
10	limitation	limitation	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Phytohemagglutinin	phytohemagglutinin	NN	NN	_	5	nmod:npmod	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	PHA	pha	NN	NN	_	5	nmod:npmod	_	_
4	)	)	-RRB-	-RRB-	_	5	punct	_	_
5	-induced	-induced	JJ	JJ	_	6	amod	_	_
6	proliferation	proliferation	NN	NN	_	29	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	sensitive	sensitive	JJ	JJ	_	11	nmod	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	14	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	resistant	resistant	JJ	JJ	_	14	conj	_	_
19	asthmatic	asthmatic	JJ	JJ	_	20	amod	_	_
20	patients	patient	NNS	NNS	_	14	dep	_	_
21	was	be	VBD	VBD	_	29	auxpass	_	_
22	significantly	significantly	RB	RB	_	29	advmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	p	p	NN	NN	_	25	dep	_	_
25	less	less	JJR	JJR	_	22	dep	_	_
26	than	than	IN	IN	_	27	case	_	_
27	0.01	0.01	CD	CD	_	25	nmod	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	inhibited	inhibit	VBN	VBN	_	0	root	_	_
30	by	by	IN	IN	_	31	case	_	_
31	dexamethasone	dexamethasone	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	10(-7)	10(-7)	CD	CD	_	34	nummod	_	_
34	mol/L	mol/l	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	29	punct	_	_
37	reflecting	reflect	VBG	VBG	_	29	xcomp	_	_
38	a	a	DT	DT	_	39	det	_	_
39	shift	shift	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	dose-response	dose-response	JJ	JJ	_	43	amod	_	_
43	curve	curve	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	29	punct	_	_

1	When	when	WRB	WRB	_	7	advmod	_	_
2	all	all	PDT	PDT	_	5	det:predet	_	_
3	the	the	DT	DT	_	5	det	_	_
4	asthmatic	asthmatic	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	analyzed	analyze	VBN	VBN	_	11	advcl	_	_
8	together	together	RB	RB	_	7	advmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	there	there	EX	EX	_	11	expl	_	_
11	was	be	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	significant	significant	JJ	JJ	_	14	amod	_	_
14	correlation	correlation	NN	NN	_	11	nsubj	_	_
15	between	between	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	degree	degree	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	sensitivity	sensitivity	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	dexamethasone	dexamethasone	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	clinical	clinical	JJ	JJ	_	28	amod	_	_
28	responsiveness	responsiveness	NN	NN	_	17	conj	_	_
29	to	to	TO	TO	_	30	case	_	_
30	prednisolone	prednisolone	JJ	JJ	_	28	nmod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	p	p	NN	NN	_	33	dep	_	_
33	less	less	RBR	RBR	_	11	parataxis	_	_
34	than	than	IN	IN	_	35	case	_	_
35	0.01	0.01	CD	CD	_	33	nmod	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	.	.	.	.	_	11	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	differences	difference	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	6	case	_	_
6	six	six	CD	CD	_	4	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	sensitive	sensitive	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	resistant	resistant	JJ	JJ	_	9	conj	_	_
12	patients	patient	NNS	NNS	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	clearance	clearance	NN	NN	_	4	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	plasma	plasma	NN	NN	_	15	nmod	_	_
18	prednisolone	prednisolone	JJ	JJ	_	17	amod	_	_
19	derived	derive	VBN	VBN	_	17	acl	_	_
20	from	from	IN	IN	_	23	case	_	_
21	orally	orally	RB	RB	_	22	advmod	_	_
22	administered	administer	VBN	VBN	_	23	amod	_	_
23	prednisone	prednisone	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	6	amod	_	_
2	blood	blood	NN	NN	_	6	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	characterized	characterize	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	five	five	CD	CD	_	12	nummod	_	_
12	sensitive	sensitive	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	seven	seven	CD	CD	_	15	nummod	_	_
15	resistant	resistant	JJ	JJ	_	12	conj	_	_
16	patients	patient	NNS	NNS	_	12	dep	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	numbers	number	NNS	NNS	_	11	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	affinities	affinity	NNS	NNS	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	receptors	receptor	NNS	NNS	_	2	nmod	_	_
9	could	could	MD	MD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	account	account	VB	VB	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	observed	observe	VBN	VBN	_	15	amod	_	_
15	difference	difference	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	susceptibility	susceptibility	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	inhibition	inhibition	NN	NN	_	18	nmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	dexamethasone	dexamethasone	NN	NN	_	24	nmod	_	_
27	in	in	FW	FW	_	24	amod	_	_
28	vitro	vitro	FW	FW	_	27	dep	_	_
29	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	clinical	clinical	JJ	JJ	_	7	amod	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	resistance	resistance	NN	NN	_	13	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	chronic	chronic	JJ	JJ	_	10	amod	_	_
10	asthma	asthma	NN	NN	_	7	nmod	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	reflect	reflect	VB	VB	_	3	ccomp	_	_
14	abnormal	abnormal	JJ	JJ	_	16	amod	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	clearance	clearance	NN	NN	_	13	dobj	_	_
17	but	but	CC	CC	_	13	cc	_	_
18	may	may	MD	MD	_	27	aux	_	_
19	be	be	VB	VB	_	27	cop	_	_
20	due	due	JJ	JJ	_	27	case	_	_
21	at	at	IN	IN	_	23	advmod	_	_
22	least	least	JJS	JJS	_	21	mwe	_	_
23	partly	partly	RB	RB	_	27	advmod	_	_
24	to	to	TO	TO	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	relative	relative	JJ	JJ	_	27	amod	_	_
27	insensitivity	insensitivity	NN	NN	_	13	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	glucocorticoids	glucocorticoid	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	lack	lack	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	sensitivity	sensitivity	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	unexplained	unexplained	JJ	JJ	_	0	root	_	_
7	but	but	CC	CC	_	6	cc	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	attributable	attributable	JJ	JJ	_	6	conj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	abnormalities	abnormality	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	interleukin-1	interleukin-1	NN	NN	_	5	compound	_	_
4	beta	beta	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	action	action	NN	NN	_	13	nmod	_	_
16	depends	depend	VBZ	VBZ	_	1	dep	_	_
17	on	on	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	signal	signal	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	downregulate	downregulate	VB	VB	_	3	xcomp	_	_
6	interleukin-1	interleukin-1	NN	NN	_	8	compound	_	_
7	beta	beta	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	monocytic	monocytic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	mechanims	mechanim	NNS	NNS	_	5	nmod	_	_
16	:	:	:	:	_	15	punct	_	_
17	direct	direct	JJ	JJ	_	18	amod	_	_
18	inhibition	inhibition	NN	NN	_	15	dep	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	destabilization	destabilization	NN	NN	_	18	conj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	preformed	preformed	JJ	JJ	_	30	amod	_	_
28	interleukin-1	interleukin-1	NN	NN	_	30	compound	_	_
29	beta	beta	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Now	now	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nature	nature	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	monocyte	monocyte	NN	NN	_	14	compound	_	_
13	activating	activating	NN	NN	_	14	compound	_	_
14	signal	signal	NN	NN	_	9	nmod	_	_
15	on	on	IN	IN	_	19	case	_	_
16	these	these	DT	DT	_	19	det	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
19	mechanims	mechanim	NNS	NNS	_	6	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	preincubated	preincubate	VBN	VBN	_	24	advcl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	hour	hour	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	then	then	RB	RB	_	13	advmod	_	_
13	stimulated	stimulate	VBN	VBN	_	5	conj	_	_
14	either	either	CC	CC	_	17	dep	_	_
15	with	with	IN	IN	_	17	case	_	_
16	bacterial	bacterial	JJ	JJ	_	17	amod	_	_
17	lipopolysaccharide	lipopolysaccharide	NN	NN	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	phorbol	phorbol	NN	NN	_	20	compound	_	_
20	myristate	myristate	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	24	punct	_	_
22	it	it	PRP	PRP	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	found	find	VBN	VBN	_	0	root	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	dexamethasone	dexamethasone	NN	NN	_	27	nsubj	_	_
27	inhibited	inhibit	VBD	VBD	_	24	ccomp	_	_
28	the	the	DT	DT	_	33	det	_	_
29	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	33	amod	_	_
30	interleukin-1	interleukin-1	NN	NN	_	33	compound	_	_
31	beta	beta	NN	NN	_	33	compound	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	production	production	NN	NN	_	27	dobj	_	_
34	,	,	,	,	_	27	punct	_	_
35	but	but	CC	CC	_	27	cc	_	_
36	the	the	DT	DT	_	39	det	_	_
37	phorbol	phorbol	NN	NN	_	38	nmod:npmod	_	_
38	myristate-induced	myristate-induced	JJ	JJ	_	39	amod	_	_
39	production	production	NN	NN	_	41	nsubjpass	_	_
40	was	be	VBD	VBD	_	41	auxpass	_	_
41	increased	increase	VBN	VBN	_	27	conj	_	_
42	3-10	3-10	CD	CD	_	41	dobj	_	_
43	fold	fold	RB	RB	_	42	advmod	_	_
44	.	.	.	.	_	24	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	seen	see	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	level	level	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	dexamethasone	dexamethasone	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	added	add	VBN	VBN	_	16	advcl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cultures	culture	NNS	NNS	_	4	nmod	_	_
8	3	3	CD	CD	_	9	nummod	_	_
9	hours	hour	NNS	NNS	_	4	nmod	_	_
10	after	after	IN	IN	_	9	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	stimulators	stimulator	NNS	NNS	_	9	dep	_	_
13	,	,	,	,	_	16	punct	_	_
14	it	it	PRP	PRP	_	16	nsubj	_	_
15	clearly	clearly	RB	RB	_	16	advmod	_	_
16	decreased	decrease	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	21	det	_	_
18	interleukin-1	interleukin-1	NN	NN	_	21	compound	_	_
19	beta	beta	NN	NN	_	21	compound	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	16	dobj	_	_
22	regardless	regardless	RB	RB	_	16	advmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	stimulator	stimulator	NN	NN	_	22	nmod	_	_
26	used	use	VBN	VBN	_	25	acl	_	_
27	(	(	-LRB-	-LRB-	_	16	punct	_	_
28	although	although	IN	IN	_	33	mark	_	_
29	the	the	DT	DT	_	30	det	_	_
30	effect	effect	NN	NN	_	33	nsubj	_	_
31	was	be	VBD	VBD	_	33	cop	_	_
32	clearly	clearly	RB	RB	_	33	advmod	_	_
33	weaker	weaker	JJR	JJR	_	16	advcl	_	_
34	on	on	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	PMA-induced	pma-induced	JJ	JJ	_	37	amod	_	_
37	mRNA	mrna	NN	NN	_	33	nmod	_	_
38	)	)	-RRB-	-RRB-	_	16	punct	_	_
39	.	.	.	.	_	16	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	phorbol	phorbol	NN	NN	_	8	nmod:npmod	_	_
8	myristate-induced	myristate-induced	JJ	JJ	_	9	amod	_	_
9	signal	signal	NN	NN	_	21	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	prolonged	prolonged	JJ	JJ	_	15	amod	_	_
12	protein	protein	NN	NN	_	15	compound	_	_
13	kinase	kinase	NN	NN	_	15	compound	_	_
14	C	c	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	9	dep	_	_
16	?	?	.	.	_	15	punct	_	_
17	)	)	-RRB-	-RRB-	_	15	punct	_	_
18	can	can	MD	MD	_	21	aux	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	inhibited	inhibit	VBN	VBN	_	4	ccomp	_	_
22	by	by	IN	IN	_	24	case	_	_
23	prior	prior	JJ	JJ	_	24	amod	_	_
24	incubation	incubation	NN	NN	_	21	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	dexamethasone	dexamethasone	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	it	it	PRP	PRP	_	30	nsubj	_	_
29	also	also	RB	RB	_	30	advmod	_	_
30	protects	protect	VBZ	VBZ	_	21	conj	_	_
31	the	the	DT	DT	_	33	det	_	_
32	induced	induce	VBN	VBN	_	33	amod	_	_
33	mRNA	mrna	NN	NN	_	30	dobj	_	_
34	for	for	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	degradative	degradative	JJ	JJ	_	37	amod	_	_
37	action	action	NN	NN	_	30	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	dexamethasone	dexamethasone	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
4	suppressor	suppressor	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	negative	negative	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	type	type	NN	NN	_	12	nmod	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	28	nsubjpass	_	_
4	which	which	WDT	WDT	_	6	nsubj	_	_
5	independently	independently	RB	RB	_	6	advmod	_	_
6	bound	bind	VBD	VBD	_	3	acl:relcl	_	_
7	to	to	TO	TO	_	9	case	_	_
8	neighboring	neighbor	VBG	VBG	_	9	amod	_	_
9	sequences	sequence	NNS	NNS	_	6	nmod	_	_
10	within	within	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	negative	negative	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	element	element	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NRE	nre	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	of	of	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	type	type	NN	NN	_	14	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	HIV-1	hiv-1	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	detected	detect	VBN	VBN	_	0	root	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	extract	extract	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	39	case	_	_
34	a	a	DT	DT	_	39	det	_	_
35	virus-infected	virus-infected	JJ	JJ	_	39	amod	_	_
36	human	human	JJ	JJ	_	39	amod	_	_
37	T	t	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	28	punct	_	_

1	One	one	CD	CD	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	novel	novel	JJ	JJ	_	11	amod	_	_
9	dyad	dyad	NN	NN	_	11	compound	_	_
10	symmetrical	symmetrical	JJ	JJ	_	11	amod	_	_
11	sequence	sequence	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	well	well	RB	RB	_	5	advmod	_	_
5	conserved	conserve	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	various	various	JJ	JJ	_	9	amod	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	isolates	isolate	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	partial	partial	JJ	JJ	_	12	amod	_	_
12	homology	homology	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	5	conj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	promoter	promoter	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	retinoblastoma	retinoblastoma	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Similar	similar	JJ	JJ	_	4	amod	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	variety	variety	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	virus-uninfected	virus-uninfected	JJ	JJ	_	15	amod	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	HeLa	hela	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	conj	_	_
19	by	by	IN	IN	_	26	case	_	_
20	means	means	NNS	NNS	_	26	dep	_	_
21	of	of	IN	IN	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	gel	gel	NN	NN	_	26	compound	_	_
24	mobility	mobility	NN	NN	_	26	compound	_	_
25	shift	shift	NN	NN	_	26	compound	_	_
26	assay	assay	NN	NN	_	6	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	bound	bind	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	putative	putative	JJ	JJ	_	10	amod	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	recognition	recognition	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	4	nmod	_	_
11	predicted	predict	VBD	VBD	_	10	acl	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	NRE	nre	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	factor	factor	NN	NN	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	bind	bind	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	typical	typical	JJ	JJ	_	12	amod	_	_
11	AP-1	ap-1	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	insertion	insertion	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	multiple	multiple	JJ	JJ	_	5	amod	_	_
5	copies	copy	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	binding	bind	VBG	VBG	_	9	amod	_	_
9	site	site	NN	NN	_	5	nmod	_	_
10	for	for	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	former	former	JJ	JJ	_	15	amod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	latter	latter	JJ	JJ	_	12	conj	_	_
15	factor	factor	NN	NN	_	9	nmod	_	_
16	into	into	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	heterologous	heterologous	JJ	JJ	_	19	amod	_	_
19	promoter	promoter	NN	NN	_	2	nmod	_	_
20	reduced	reduce	VBD	VBD	_	0	root	_	_
21	the	the	DT	DT	_	23	det	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	one-tenth	one-tenth	CD	CD	_	20	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	one-third	one-third	CD	CD	_	25	conj	_	_
28	,	,	,	,	_	20	punct	_	_
29	respectively	respectively	RB	RB	_	20	advmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	each	each	DT	DT	_	4	det	_	_
4	factor	factor	NN	NN	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	function	function	VB	VB	_	0	root	_	_
7	as	as	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	novel	novel	JJ	JJ	_	11	amod	_	_
10	negative	negative	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	transcription	transcription	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kB	nf-kb	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	thymocytes	thymocyte	NNS	NNS	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	NF-kB	nf-kb	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	eukaryotic	eukaryotic	JJ	JJ	_	7	amod	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	11	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	conj	_	_
8	,	,	,	,	_	11	punct	_	_
9	NF-kB	nf-kb	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	bound	bind	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	cytoplasmic	cytoplasmic	JJ	JJ	_	16	amod	_	_
15	proteic	proteic	JJ	JJ	_	16	amod	_	_
16	inhibitor	inhibitor	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	IkB	ikb	NN	NN	_	16	appos	_	_
20	.	.	.	.	_	11	punct	_	_

1	Treatment	treatment	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	mitogens	mitogen	NNS	NNS	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	phorbol	phorbol	NN	NN	_	9	compound	_	_
9	esters	ester	NNS	NNS	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	or	or	CC	CC	_	6	cc	_	_
12	cytokines	cytokine	NNS	NNS	_	6	conj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	TNF	tnf	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	induces	induce	VBZ	VBZ	_	0	root	_	_
18	NF-kB	nf-kb	NN	NN	_	20	compound	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	subsequent	subsequent	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	20	conj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	NF-kB	nf-kb	NN	NN	_	27	nmod:npmod	_	_
27	dependent	dependent	JJ	JJ	_	30	amod	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kB	nf-kb	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	thymic	thymic	JJ	JJ	_	13	amod	_	_
13	progenitors	progenitor	NNS	NNS	_	5	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	differences	difference	NNS	NNS	_	2	dobj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	(Ca2+)i	(ca2+)i	NN	NN	_	6	compound	_	_
6	requirement	requirement	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	6	amod	_	_
8	NF-kB	nf-kb	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	dep	_	_
10	in	in	IN	IN	_	11	case	_	_
11	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
12	as	as	IN	IN	_	13	mark	_	_
13	compared	compare	VBN	VBN	_	3	dep	_	_
14	to	to	TO	TO	_	17	case	_	_
15	mature	mature	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	thymocytes	thymocyte	NNS	NNS	_	8	nsubj	_	_
8	have	have	VBP	VBP	_	5	ccomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	active	active	JJ	JJ	_	12	amod	_	_
12	form	form	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kB	nf-kb	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	they	they	PRP	PRP	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	activated	activate	VBN	VBN	_	16	ccomp	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	20	advmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Elevated	elevated	JJ	JJ	_	4	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	concentrations	concentration	NNS	NNS	_	0	root	_	_
5	before	before	IN	IN	_	9	nmod	_	_
6	and	and	CC	CC	_	9	cc	_	_
7	after	after	IN	IN	_	9	conj	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	therapy	therapy	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	13	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	atopic	atopic	JJ	JJ	_	18	amod	_	_
18	dermatitis	dermatitis	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	number	number	NN	NN	_	25	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	affinity	affinity	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	atopic	atopic	JJ	JJ	_	17	amod	_	_
17	dermatitis	dermatitis	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	AD	ad	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	healthy	healthy	JJ	JJ	_	23	amod	_	_
23	controls	control	NNS	NNS	_	14	conj	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	determined	determine	VBN	VBN	_	0	root	_	_
26	under	under	IN	IN	_	28	case	_	_
27	baseline	baseline	NN	NN	_	28	compound	_	_
28	conditions	condition	NNS	NNS	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	after	after	IN	IN	_	35	case	_	_
31	a	a	DT	DT	_	35	det	_	_
32	defined	define	VBN	VBN	_	35	amod	_	_
33	oral	oral	JJ	JJ	_	35	amod	_	_
34	glucocorticoid	glucocorticoid	NN	NN	_	35	compound	_	_
35	treatment	treatment	NN	NN	_	28	conj	_	_
36	.	.	.	.	_	25	punct	_	_

1	Patients	patient	NNS	NNS	_	9	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	AD	ad	NN	NN	_	1	nmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	n	n	NN	NN	_	1	dep	_	_
6	=	=	JJ	JJ	_	5	amod	_	_
7	15	15	CD	CD	_	6	dep	_	_
8	)	)	-RRB-	-RRB-	_	5	punct	_	_
9	exhibited	exhibit	VBD	VBD	_	0	root	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	more	more	JJR	JJR	_	13	amod	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	9	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GR	gr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	per	per	IN	IN	_	18	case	_	_
18	cell	cell	NN	NN	_	13	nmod	_	_
19	than	than	IN	IN	_	22	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	control	control	NN	NN	_	22	compound	_	_
22	group	group	NN	NN	_	13	dep	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	n	n	NN	NN	_	22	dep	_	_
25	=	=	JJ	JJ	_	24	amod	_	_
26	22	22	CD	CD	_	25	dep	_	_
27	)	)	-RRB-	-RRB-	_	24	punct	_	_
28	,	,	,	,	_	9	punct	_	_
29	while	while	IN	IN	_	35	mark	_	_
30	the	the	DT	DT	_	32	det	_	_
31	GR	gr	NN	NN	_	32	compound	_	_
32	affinity	affinity	NN	NN	_	35	nsubj	_	_
33	did	do	VBD	VBD	_	35	aux	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	differ	differ	VB	VB	_	9	advcl	_	_
36	.	.	.	.	_	9	punct	_	_

1	Methylprednisolone	methylprednisolone	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	reduction	reduction	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	GR	gr	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	7	nmod	_	_
12	per	per	IN	IN	_	13	case	_	_
13	cell	cell	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	steroid-treated	steroid-treated	JJ	JJ	_	18	amod	_	_
17	control	control	NN	NN	_	18	compound	_	_
18	group	group	NN	NN	_	7	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	n	n	NN	NN	_	18	appos	_	_
21	=	=	JJ	JJ	_	20	amod	_	_
22	10	10	CD	CD	_	21	dep	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	contrast	contrast	NN	NN	_	7	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	patients	patient	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dissociation	dissociation	NN	NN	_	3	compound	_	_
3	constant	constant	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affected	affect	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	methylprednisolone	methylprednisolone	JJ	JJ	_	9	amod	_	_
9	treatment	treatment	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	either	either	DT	DT	_	12	det	_	_
12	group	group	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	view	view	NN	NN	_	26	nmod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	therapeutic	therapeutic	JJ	JJ	_	6	amod	_	_
6	efficiency	efficiency	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	AD	ad	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	findings	finding	NNS	NNS	_	6	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	abnormal	abnormal	JJ	JJ	_	15	amod	_	_
15	cAMP	camp	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cAMP-phosphodiesterase	camp-phosphodiesterase	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	26	punct	_	_
20	the	the	DT	DT	_	23	det	_	_
21	elevated	elevated	JJ	JJ	_	23	amod	_	_
22	GR	gr	NN	NN	_	23	compound	_	_
23	concentrations	concentration	NNS	NNS	_	26	nsubj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	AD	ad	NN	NN	_	23	nmod	_	_
26	lend	lend	VBP	VBP	_	0	root	_	_
27	support	support	NN	NN	_	26	dobj	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	hypothesis	hypothesis	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	a	a	DT	DT	_	35	det	_	_
33	compensatory	compensatory	JJ	JJ	_	35	amod	_	_
34	GR	gr	NN	NN	_	35	compound	_	_
35	upregulation	upregulation	NN	NN	_	30	nmod	_	_
36	due	due	JJ	JJ	_	35	amod	_	_
37	to	to	TO	TO	_	40	case	_	_
38	an	a	DT	DT	_	40	det	_	_
39	insufficient	insufficient	JJ	JJ	_	40	amod	_	_
40	action	action	NN	NN	_	36	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	endogenous	endogenous	JJ	JJ	_	43	amod	_	_
43	cortisol	cortisol	NN	NN	_	40	nmod	_	_
44	or	or	CC	CC	_	40	cc	_	_
45	to	to	TO	TO	_	49	case	_	_
46	altered	altered	JJ	JJ	_	49	amod	_	_
47	cAMP-induced	camp-induced	JJ	JJ	_	46	dep	_	_
48	GR	gr	NN	NN	_	49	compound	_	_
49	expression	expression	NN	NN	_	40	conj	_	_
50	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	jun	jun	NN	NN	_	9	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	fos	fos	NN	NN	_	4	conj	_	_
7	gene	gene	NN	NN	_	9	compound	_	_
8	family	family	NN	NN	_	9	compound	_	_
9	members	member	NNS	NNS	_	2	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	14	amod	_	_
12	induced	induce	VBD	VBD	_	11	dep	_	_
13	hemopoietic	hemopoietic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	2	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Terminal	terminal	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	leukemic	leukemic	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	2	nmod	_	_
8	U-937	u-937	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	HL-60	hl-60	NN	NN	_	8	conj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	2	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	accompanied	accompany	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	marked	marked	JJ	JJ	_	17	amod	_	_
17	changes	change	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	18	nsubjpass	_	_
10	of	of	IN	IN	_	16	case	_	_
11	jun	jun	NN	NN	_	16	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	fos	fos	NN	NN	_	11	conj	_	_
14	gene	gene	NN	NN	_	16	compound	_	_
15	family	family	NN	NN	_	16	compound	_	_
16	members	member	NNS	NNS	_	9	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	induced	induce	VBN	VBN	_	6	ccomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	variable	variable	JJ	JJ	_	21	amod	_	_
21	kinetics	kinetics	NNS	NNS	_	18	nmod	_	_
22	during	during	IN	IN	_	25	case	_	_
23	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	25	amod	_	_
24	induced	induce	VBD	VBD	_	23	dep	_	_
25	differentiation	differentiation	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	18	punct	_	_
27	with	with	IN	IN	_	31	mark	_	_
28	c-jun	c-jun	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	31	nsubj	_	_
30	best	best	RB	RB	_	31	advmod	_	_
31	paralleling	paralleling	JJ	JJ	_	18	advcl	_	_
32	differentiation	differentiation	NN	NN	_	31	dobj	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	generation	generation	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	AP-1	ap-1	NN	NN	_	5	compound	_	_
5	complexes	complex	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	as	as	IN	IN	_	8	mark	_	_
8	measured	measure	VBN	VBN	_	2	dep	_	_
9	by	by	IN	IN	_	12	case	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	closely	closely	RB	RB	_	15	advmod	_	_
15	parallels	parallel	VBZ	VBZ	_	0	root	_	_
16	morphological	morphological	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	15	punct	_	_

1	Furthermore	furthermore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	complexes	complex	NNS	NNS	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	regulate	regulate	VB	VB	_	4	acl	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	increased	increase	VBN	VBN	_	16	amod	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	from	from	IN	IN	_	22	case	_	_
18	an	a	DT	DT	_	22	det	_	_
19	AP-1	ap-1	NN	NN	_	20	dep	_	_
20	driven	drive	VBN	VBN	_	22	amod	_	_
21	reporter	reporter	NN	NN	_	22	compound	_	_
22	construct	construct	NN	NN	_	16	nmod	_	_
23	and	and	CC	CC	_	16	cc	_	_
24	marked	marked	JJ	JJ	_	25	amod	_	_
25	increases	increase	NNS	NNS	_	16	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	endogenous	endogenous	JJ	JJ	_	33	amod	_	_
31	AP-1	ap-1	NN	NN	_	33	compound	_	_
32	regulated	regulated	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	13	punct	_	_

1	Differentiation	differentiation	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	8	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	water	water	NN	NN	_	5	nmod:npmod	_	_
5	soluble	soluble	JJ	JJ	_	7	amod	_	_
6	phorbol	phorbol	NN	NN	_	7	compound	_	_
7	esters	ester	NNS	NNS	_	3	dobj	_	_
8	reveal	reveal	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	differentiation	differentiation	NN	NN	_	11	nsubj	_	_
11	becomes	become	VBZ	VBZ	_	8	ccomp	_	_
12	irreversible	irreversible	JJ	JJ	_	11	xcomp	_	_
13	soon	soon	RB	RB	_	11	advmod	_	_
14	after	after	IN	IN	_	16	mark	_	_
15	AP-1	ap-1	NN	NN	_	16	nsubj	_	_
16	appears	appear	VBZ	VBZ	_	13	dep	_	_
17	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	tight	tight	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	16	nsubj	_	_
4	between	between	IN	IN	_	6	case	_	_
5	c-jun	c-jun	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	generation	generation	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	AP-1	ap-1	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	differentiation	differentiation	NN	NN	_	6	conj	_	_
16	suggests	suggest	VBZ	VBZ	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	critical	critical	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	for	for	IN	IN	_	25	case	_	_
21	this	this	DT	DT	_	25	det	_	_
22	gene	gene	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	transcriptional	transcriptional	JJ	JJ	_	22	conj	_	_
25	complex	complex	NN	NN	_	19	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	process	process	NN	NN	_	19	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	14	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	T	t	NN	NN	_	5	nmod:npmod	_	_
5	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	appos	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	HMG	hmg	NN	NN	_	12	compound	_	_
11	box	box	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	interacts	interact	VBZ	VBZ	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	sequence	sequence	NN	NN	_	17	compound	_	_
17	motifs	motif	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	25	case	_	_
19	the	the	DT	DT	_	25	det	_	_
20	TCR	tcr	NN	NN	_	21	compound	_	_
21	beta	beta	NN	NN	_	25	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	TCR	tcr	NN	NN	_	24	compound	_	_
24	delta	delta	NN	NN	_	21	conj	_	_
25	enhancers	enhancer	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cloned	clone	VBN	VBN	_	4	conj	_	_
7	TCF-1	tcf-1	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	11	nmod:npmod	_	_
11	cell-specific	cell-specific	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	7	appos	_	_
14	with	with	IN	IN	_	15	case	_	_
15	specificity	specificity	NN	NN	_	13	nmod	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	AACAAAG	aacaaag	NN	NN	_	19	compound	_	_
19	motif	motif	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	CD3	cd3	NN	NN	_	24	compound	_	_
23	epsilon	epsilon	NN	NN	_	24	compound	_	_
24	enhancer	enhancer	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	for	for	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	TTCAAAG	ttcaaag	NN	NN	_	29	compound	_	_
29	motif	motif	NN	NN	_	19	conj	_	_
30	in	in	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	TCR	tcr	NN	NN	_	34	compound	_	_
33	alpha	alpha	NN	NN	_	34	compound	_	_
34	enhancer	enhancer	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	nsubj	_	_
2	belongs	belong	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	family	family	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription-regulating	transcription-regulating	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	share	share	VBP	VBP	_	8	acl:relcl	_	_
11	a	a	DT	DT	_	12	det	_	_
12	region	region	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	homology	homology	NN	NN	_	12	nmod	_	_
15	termed	term	VBN	VBN	_	12	acl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	HMG-box	hmg-box	NN	NN	_	15	xcomp	_	_
18	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	gel	gel	NN	NN	_	8	compound	_	_
7	retardation	retardation	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	4	nmod	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	TCF-1	tcf-1	NN	NN	_	12	dep	_	_
11	specifically	specifically	RB	RB	_	12	advmod	_	_
12	recognizes	recognize	VBZ	VBZ	_	4	dep	_	_
13	the	the	DT	DT	_	17	det	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	beta	beta	NN	NN	_	17	compound	_	_
16	5	5	CD	CD	_	17	nummod	_	_
17	element	element	NN	NN	_	12	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	TCR	tcr	NN	NN	_	22	compound	_	_
21	beta	beta	NN	NN	_	22	compound	_	_
22	enhancer	enhancer	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	the	the	DT	DT	_	28	det	_	_
25	T	t	NN	NN	_	28	compound	_	_
26	delta	delta	NN	NN	_	28	compound	_	_
27	7	7	CD	CD	_	28	nummod	_	_
28	element	element	NN	NN	_	17	conj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	TCR	tcr	NN	NN	_	33	compound	_	_
32	delta	delta	NN	NN	_	33	compound	_	_
33	enhancer	enhancer	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	all	all	DT	DT	_	7	det	_	_
7	elements	element	NNS	NNS	_	4	nmod	_	_
8	recognized	recognize	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	TCF-1	tcf-1	NN	NN	_	8	nmod	_	_
11	defines	define	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	21	det	_	_
13	consensus	consensus	NN	NN	_	21	compound	_	_
14	motif	motif	NN	NN	_	21	compound	_	_
15	A/T	a/t	NN	NN	_	21	compound	_	_
16	A/T	a/t	NN	NN	_	21	compound	_	_
17	C	c	NN	NN	_	21	compound	_	_
18	A	a	NN	NN	_	21	compound	_	_
19	A/G	a/g	NN	NN	_	21	compound	_	_
20	A	a	NN	NN	_	21	compound	_	_
21	G	g	NN	NN	_	11	dobj	_	_
22	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	TCF-1	tcf-1	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	control	control	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	several	several	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	14	nmod:npmod	_	_
14	cell-specific	cell-specific	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	might	might	MD	MD	_	19	aux	_	_
18	thus	thus	RB	RB	_	19	advmod	_	_
19	play	play	VB	VB	_	7	conj	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	establishment	establishment	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	maintenance	maintenance	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	mature	mature	JJ	JJ	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	phenotype	phenotype	NN	NN	_	25	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cellular	cellular	JJ	JJ	_	4	amod	_	_
3	oncogene	oncogene	NN	NN	_	4	compound	_	_
4	c-myb	c-myb	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	interact	interact	VB	VB	_	0	root	_	_
7	synergistically	synergistically	RB	RB	_	6	advmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	13	amod	_	_
11	virus	virus	NN	NN	_	13	compound	_	_
12	BZLF1	bzlf1	NN	NN	_	13	compound	_	_
13	transactivator	transactivator	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	lymphoid	lymphoid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Regulation	regulation	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	replicative	replicative	JJ	JJ	_	4	amod	_	_
4	functions	function	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	EBV	ebv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	genome	genome	NN	NN	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	0	root	_	_
15	through	through	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	virally	virally	RB	RB	_	20	advmod	_	_
20	encoded	encode	VBN	VBN	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	Z	z	NN	NN	_	22	appos	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	BZLF1	bzlf1	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	27	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	Z	z	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	product	product	NN	NN	_	27	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	binds	bind	VBZ	VBZ	_	8	acl:relcl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	AP-1	ap-1	NN	NN	_	14	compound	_	_
14	sites	site	NNS	NNS	_	11	nmod	_	_
15	as	as	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	homodimer	homodimer	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	has	have	VBZ	VBZ	_	11	conj	_	_
20	sequence	sequence	NN	NN	_	21	compound	_	_
21	similarity	similarity	NN	NN	_	19	dobj	_	_
22	to	to	TO	TO	_	23	case	_	_
23	c-Fos	c-fos	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	8	punct	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	efficiently	efficiently	RB	RB	_	27	advmod	_	_
27	activate	activate	VB	VB	_	3	ccomp	_	_
28	the	the	DT	DT	_	31	det	_	_
29	EBV	ebv	NN	NN	_	31	compound	_	_
30	early	early	JJ	JJ	_	31	amod	_	_
31	promoter	promoter	NN	NN	_	27	dobj	_	_
32	,	,	,	,	_	31	punct	_	_
33	BMRF1	bmrf1	NN	NN	_	31	appos	_	_
34	,	,	,	,	_	31	punct	_	_
35	in	in	IN	IN	_	38	case	_	_
36	certain	certain	JJ	JJ	_	38	amod	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	types	type	NNS	NNS	_	27	nmod	_	_
39	(	(	-LRB-	-LRB-	_	43	punct	_	_
40	i.e.	i.e.	FW	FW	_	43	dep	_	_
41	,	,	,	,	_	43	punct	_	_
42	HeLa	hela	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	38	dep	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	but	but	CC	CC	_	46	cc	_	_
46	not	not	RB	RB	_	38	cc	_	_
47	others	other	NNS	NNS	_	38	conj	_	_
48	(	(	-LRB-	-LRB-	_	52	punct	_	_
49	i.e.	i.e.	FW	FW	_	52	dep	_	_
50	,	,	,	,	_	52	punct	_	_
51	Jurkat	jurkat	NN	NN	_	52	compound	_	_
52	cells	cell	NNS	NNS	_	47	dep	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	c-myb	c-myb	NN	NN	_	8	compound	_	_
7	proto-oncogene	proto-oncogene	NN	NN	_	8	compound	_	_
8	product	product	NN	NN	_	21	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	itself	itself	PRP	PRP	_	8	acl:relcl	_	_
13	a	a	DT	DT	_	15	det	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	12	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	transactivator	transactivator	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	8	punct	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	interact	interact	VB	VB	_	3	ccomp	_	_
22	synergistically	synergistically	RB	RB	_	21	advmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	Z	z	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	26	mark	_	_
26	activating	activate	VBG	VBG	_	21	advcl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	BMRF1	bmrf1	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	Jurkat	jurkat	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	26	nmod	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	a	a	DT	DT	_	36	det	_	_
35	T-cell	t-cell	NN	NN	_	36	compound	_	_
36	line	line	NN	NN	_	32	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	or	or	CC	CC	_	32	cc	_	_
39	Raji	raji	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	32	conj	_	_
41	(	(	-LRB-	-LRB-	_	44	punct	_	_
42	an	a	DT	DT	_	44	det	_	_
43	EBV-positive	ebv-positive	JJ	JJ	_	44	amod	_	_
44	B-cell	b-cell	NN	NN	_	40	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	,	,	,	,	_	3	punct	_	_
47	whereas	whereas	IN	IN	_	3	dep	_	_
48	the	the	DT	DT	_	51	det	_	_
49	c-myb	c-myb	NN	NN	_	51	compound	_	_
50	gene	gene	NN	NN	_	51	compound	_	_
51	product	product	NN	NN	_	54	nsubj	_	_
52	by	by	IN	IN	_	53	case	_	_
53	itself	itself	PRP	PRP	_	51	nmod	_	_
54	has	have	VBZ	VBZ	_	3	parataxis	_	_
55	little	little	JJ	JJ	_	56	amod	_	_
56	effect	effect	NN	NN	_	54	dobj	_	_
57	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	simian	simian	JJ	JJ	_	6	amod	_	_
3	virus	virus	NN	NN	_	6	compound	_	_
4	40	40	CD	CD	_	6	nummod	_	_
5	early	early	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	10	auxpass	_	_
8	also	also	RB	RB	_	10	advmod	_	_
9	synergistically	synergistically	RB	RB	_	10	advmod	_	_
10	activated	activate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Z/c-myb	z/c-myb	NN	NN	_	14	compound	_	_
14	combination	combination	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Synergistic	synergistic	JJ	JJ	_	2	amod	_	_
2	transactivation	transactivation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	BMRF1	bmrf1	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Z/c-myb	z/c-myb	NN	NN	_	10	compound	_	_
10	combination	combination	NN	NN	_	2	nmod	_	_
11	appears	appear	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	involve	involve	VB	VB	_	11	xcomp	_	_
14	direct	direct	JJ	JJ	_	15	amod	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Z	z	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	15	nmod	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	19	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	c-myb	c-myb	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	30-bp	30-bp	JJ	JJ	_	3	amod	_	_
3	sequence	sequence	NN	NN	_	21	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	BMRF1	bmrf1	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	contains	contain	VBZ	VBZ	_	7	acl:relcl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	Z	z	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	9	dobj	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	a	a	DT	DT	_	18	det	_	_
16	consensus	consensus	NN	NN	_	18	compound	_	_
17	AP-1	ap-1	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	13	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	sufficient	sufficient	JJ	JJ	_	0	root	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	transfer	transfer	VB	VB	_	21	xcomp	_	_
24	high-level	high-level	JJ	JJ	_	26	amod	_	_
25	lymphoid-specific	lymphoid-specific	JJ	JJ	_	26	amod	_	_
26	responsiveness	responsiveness	NN	NN	_	23	dobj	_	_
27	to	to	TO	TO	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	Z/c-myb	z/c-myb	NN	NN	_	30	compound	_	_
30	combination	combination	NN	NN	_	26	nmod	_	_
31	to	to	TO	TO	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	heterologous	heterologous	JJ	JJ	_	34	amod	_	_
34	promoter	promoter	NN	NN	_	23	nmod	_	_
35	.	.	.	.	_	21	punct	_	_

1	That	that	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	c-myb	c-myb	NN	NN	_	5	compound	_	_
4	oncogene	oncogene	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	interact	interact	VB	VB	_	19	csubj	_	_
8	synergistically	synergistically	RB	RB	_	7	advmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	EBV-encoded	ebv-encoded	JJ	JJ	_	12	amod	_	_
12	member	member	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	leucine	leucine	NN	NN	_	18	compound	_	_
16	zipper	zipper	NN	NN	_	18	compound	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	family	family	NN	NN	_	12	nmod	_	_
19	suggests	suggest	VBZ	VBZ	_	0	root	_	_
20	c-myb	c-myb	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	likely	likely	JJ	JJ	_	19	ccomp	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	engage	engage	VB	VB	_	22	xcomp	_	_
25	in	in	IN	IN	_	27	case	_	_
26	similar	similar	JJ	JJ	_	27	amod	_	_
27	interactions	interaction	NNS	NNS	_	24	nmod	_	_
28	with	with	IN	IN	_	32	case	_	_
29	cellularly	cellularly	RB	RB	_	30	advmod	_	_
30	encoded	encode	VBN	VBN	_	32	amod	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Endocrine	endocrine	JJ	JJ	_	4	amod	_	_
3	status	status	NN	NN	_	4	compound	_	_
4	changes	change	NNS	NNS	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	children	child	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	bronchial	bronchial	JJ	JJ	_	9	amod	_	_
9	asthma	asthma	NN	NN	_	6	nmod	_	_
10	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	made	make	VBN	VBN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	adrenocortical	adrenocortical	JJ	JJ	_	7	amod	_	_
7	function	function	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	measuring	measure	VBG	VBG	_	7	acl	_	_
10	blood	blood	NN	NN	_	13	compound	_	_
11	plasma	plasma	NN	NN	_	13	compound	_	_
12	cortisol	cortisol	NN	NN	_	13	compound	_	_
13	concentration	concentration	NN	NN	_	9	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	amount	amount	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
21	as	as	RB	RB	_	7	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	thyroid	thyroid	NN	NN	_	25	compound	_	_
25	function	function	NN	NN	_	7	conj	_	_
26	by	by	IN	IN	_	27	mark	_	_
27	measuring	measure	VBG	VBG	_	25	acl	_	_
28	blood	blood	NN	NN	_	30	compound	_	_
29	plasma	plasma	NN	NN	_	30	compound	_	_
30	triidothyronine	triidothyronine	NN	NN	_	27	dobj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	thyroxine	thyroxine	JJ	JJ	_	33	amod	_	_
33	concentration	concentration	NN	NN	_	30	conj	_	_
34	in	in	IN	IN	_	38	case	_	_
35	58	58	CD	CD	_	38	nummod	_	_
36	bronchial	bronchial	JJ	JJ	_	38	amod	_	_
37	asthma	asthma	NN	NN	_	38	compound	_	_
38	children	child	NNS	NNS	_	30	nmod	_	_
39	aged	aged	JJ	JJ	_	38	amod	_	_
40	1	1	CD	CD	_	42	compound	_	_
41	to	to	TO	TO	_	42	dep	_	_
42	14	14	CD	CD	_	43	nummod	_	_
43	years	year	NNS	NNS	_	39	nmod:tmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	alterations	alteration	NNS	NNS	_	3	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	indicated	indicate	VBN	VBN	_	13	amod	_	_
12	endocrine	endocrine	JJ	JJ	_	13	amod	_	_
13	glands	gland	NNS	NNS	_	8	nmod	_	_
14	depending	depend	VBG	VBG	_	17	case	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	intensity	intensity	NN	NN	_	3	advcl	_	_
18	of	of	IN	IN	_	21	case	_	_
19	bronchial	bronchial	JJ	JJ	_	21	amod	_	_
20	patency	patency	NN	NN	_	21	compound	_	_
21	disorders	disorder	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	nature	nature	NN	NN	_	17	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	therapeutic	therapeutic	JJ	JJ	_	28	amod	_	_
28	measures	measure	NNS	NNS	_	24	nmod	_	_
29	carried	carry	VBN	VBN	_	28	acl	_	_
30	out	out	RP	RP	_	29	compound:prt	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	29-kDa	29-kda	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	10	nsubj	_	_
4	phosphorylated	phosphorylate	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	8	case	_	_
6	thrombin-activated	thrombin-activated	JJ	JJ	_	8	amod	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	platelets	platelet	NNS	NNS	_	4	nmod	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	forms	form	NNS	NNS	_	0	root	_	_
11	of	of	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	estrogen	estrogen	NN	NN	_	14	nmod:npmod	_	_
14	receptor-related	receptor-related	JJ	JJ	_	18	amod	_	_
15	27-kDa	27-kda	JJ	JJ	_	18	amod	_	_
16	heat	heat	NN	NN	_	18	compound	_	_
17	shock	shock	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	nsubj	_	_
2	plays	play	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	critical	critical	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	platelet	platelet	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	hemostasis	hemostasis	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	thrombosis	thrombosis	NN	NN	_	8	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	thrombin	thrombin	NN	NN	_	2	nmod	_	_
5	leads	lead	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	multiple	multiple	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	most	most	JJS	JJS	_	17	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	13	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	unidentified	unidentified	JJ	JJ	_	11	acl:relcl	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	characterized	characterize	VBN	VBN	_	0	root	_	_
4	several	several	JJ	JJ	_	6	amod	_	_
5	29-kDa	29-kda	JJ	JJ	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	3	dobj	_	_
7	that	that	WDT	WDT	_	10	nsubjpass	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	rapidly	rapidly	RB	RB	_	10	advmod	_	_
10	phosphorylated	phosphorylate	VBN	VBN	_	6	acl:relcl	_	_
11	following	follow	VBG	VBG	_	12	case	_	_
12	exposure	exposure	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	intact	intact	JJ	JJ	_	16	amod	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	platelets	platelet	NNS	NNS	_	12	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	thrombin	thrombin	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	murine	murine	JJ	JJ	_	4	amod	_	_
3	monoclonal	monoclonal	JJ	JJ	_	4	amod	_	_
4	antibody	antibody	NN	NN	_	14	nsubj	_	_
5	raised	raise	VBN	VBN	_	4	acl	_	_
6	to	to	TO	TO	_	12	case	_	_
7	an	a	DT	DT	_	12	det	_	_
8	unidentified	unidentified	JJ	JJ	_	12	amod	_	_
9	estrogen	estrogen	NN	NN	_	10	nmod:npmod	_	_
10	receptor-related	receptor-related	JJ	JJ	_	12	amod	_	_
11	29-kDa	29-kda	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	5	nmod	_	_
13	selectively	selectively	RB	RB	_	14	advmod	_	_
14	recognized	recognize	VBD	VBD	_	0	root	_	_
15	these	these	DT	DT	_	16	det	_	_
16	proteins	protein	NNS	NNS	_	14	dobj	_	_
17	as	as	RB	RB	_	16	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	a	a	DT	DT	_	26	det	_	_
21	more	more	RBR	RBR	_	22	advmod	_	_
22	basic	basic	JJ	JJ	_	26	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	unphosphorylated	unphosphorylated	JJ	JJ	_	22	dep	_	_
25	27-kDa	27-kda	JJ	JJ	_	26	amod	_	_
26	protein	protein	NN	NN	_	16	conj	_	_
27	.	.	.	.	_	14	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	thrombin	thrombin	NN	NN	_	2	nmod	_	_
5	led	lead	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	marked	marked	JJ	JJ	_	9	amod	_	_
9	shift	shift	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	proportion	proportion	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	protein	protein	NN	NN	_	12	nmod	_	_
15	from	from	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	27-kDa	27-kda	JJ	JJ	_	19	amod	_	_
18	unphosphorylated	unphosphorylated	JJ	JJ	_	19	amod	_	_
19	form	form	NN	NN	_	9	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	29-kDa	29-kda	JJ	JJ	_	24	amod	_	_
23	phosphoprotein	phosphoprotein	NN	NN	_	24	compound	_	_
24	species	species	NNS	NNS	_	9	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	this	this	DT	DT	_	3	det	_	_
3	antibody	antibody	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	isolated	isolate	VBD	VBD	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	sequenced	sequence	VBD	VBD	_	6	conj	_	_
9	a	a	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	cDNA	cdna	NN	NN	_	12	compound	_	_
12	clone	clone	NN	NN	_	6	dobj	_	_
13	encoding	encode	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	protein	protein	NN	NN	_	13	dobj	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	identical	identical	JJ	JJ	_	15	acl:relcl	_	_
19	to	to	TO	TO	_	25	case	_	_
20	the	the	DT	DT	_	25	det	_	_
21	mammalian	mammalian	JJ	JJ	_	25	amod	_	_
22	27-kDa	27-kda	JJ	JJ	_	25	amod	_	_
23	heat	heat	NN	NN	_	25	compound	_	_
24	shock	shock	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	18	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	HSP27	hsp27	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	25	punct	_	_
30	a	a	DT	DT	_	31	det	_	_
31	protein	protein	NN	NN	_	25	appos	_	_
32	of	of	IN	IN	_	34	case	_	_
33	uncertain	uncertain	JJ	JJ	_	34	amod	_	_
34	function	function	NN	NN	_	31	nmod	_	_
35	that	that	WDT	WDT	_	37	nsubjpass	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	known	know	VBN	VBN	_	31	acl:relcl	_	_
38	to	to	TO	TO	_	40	mark	_	_
39	be	be	VB	VB	_	40	auxpass	_	_
40	phosphorylated	phosphorylate	VBN	VBN	_	37	ccomp	_	_
41	to	to	TO	TO	_	43	case	_	_
42	several	several	JJ	JJ	_	43	amod	_	_
43	forms	form	NNS	NNS	_	40	nmod	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	to	to	TO	TO	_	48	mark	_	_
46	be	be	VB	VB	_	48	auxpass	_	_
47	transcriptionally	transcriptionally	RB	RB	_	48	advmod	_	_
48	induced	induce	VBN	VBN	_	40	conj	_	_
49	by	by	IN	IN	_	50	case	_	_
50	estrogen	estrogen	NN	NN	_	40	nmod	_	_
51	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	29-kDa	29-kda	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	confirmed	confirm	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	mark	_	_
7	be	be	VB	VB	_	9	cop	_	_
8	phosphorylated	phosphorylate	VBN	VBN	_	9	amod	_	_
9	forms	form	NNS	NNS	_	5	xcomp	_	_
10	of	of	IN	IN	_	11	case	_	_
11	HSP27	hsp27	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	immunoprecipitation	immunoprecipitation	NN	NN	_	14	compound	_	_
14	studies	study	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	``	``	``	``	_	7	punct	_	_
5	estrogen	estrogen	NN	NN	_	6	nmod:npmod	_	_
6	receptor-related	receptor-related	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	HSP27	hsp27	NN	NN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	the	the	DT	DT	_	16	det	_	_
13	three	three	CD	CD	_	16	nummod	_	_
14	major	major	JJ	JJ	_	16	amod	_	_
15	29-kDa	29-kda	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	22	nsubj	_	_
17	phosphorylated	phosphorylate	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	thrombin-activated	thrombin-activated	JJ	JJ	_	20	amod	_	_
20	platelets	platelet	NNS	NNS	_	17	nmod	_	_
21	are	be	VBP	VBP	_	22	cop	_	_
22	forms	form	NNS	NNS	_	9	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	HSP27	hsp27	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	HSP27	hsp27	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	signal	signal	NN	NN	_	12	compound	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	events	event	NNS	NNS	_	5	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	platelet	platelet	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	cofactor	cofactor	NN	NN	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	regulates	regulate	VBZ	VBZ	_	4	acl:relcl	_	_
7	dimerization	dimerization	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	mammalian	mammalian	JJ	JJ	_	12	amod	_	_
11	homeodomain	homeodomain	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Dimerization	dimerization	NN	NN	_	6	nsubj	_	_
2	among	among	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	has	have	VBZ	VBZ	_	6	aux	_	_
6	become	become	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	recurrent	recurrent	JJ	JJ	_	9	amod	_	_
9	theme	theme	NN	NN	_	6	xcomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	regulation	regulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	eukaryotic	eukaryotic	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Hepatocyte	hepatocyte	NN	NN	_	4	compound	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	factor-1	factor-1	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	HNF-1	hnf-1	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	homeodomain-containing	homeodomain-containing	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	0	root	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	functions	function	VBZ	VBZ	_	12	acl:relcl	_	_
15	as	as	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	dimer	dimer	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	dimerization	dimerization	NN	NN	_	3	compound	_	_
3	cofactor	cofactor	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HNF-1	hnf-1	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	DCoH	dcoh	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	displayed	display	VBD	VBD	_	11	ccomp	_	_
14	a	a	DT	DT	_	17	det	_	_
15	restricted	restricted	JJ	JJ	_	17	amod	_	_
16	tissue	tissue	NN	NN	_	17	compound	_	_
17	distribution	distribution	NN	NN	_	13	dobj	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	bind	bind	VB	VB	_	13	conj	_	_
22	to	to	TO	TO	_	23	case	_	_
23	DNA	dna	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	but	but	CC	CC	_	27	cc	_	_
26	,	,	,	,	_	27	punct	_	_
27	rather	rather	RB	RB	_	13	cc	_	_
28	,	,	,	,	_	13	punct	_	_
29	selectively	selectively	RB	RB	_	30	advmod	_	_
30	stabilized	stabilize	VBD	VBD	_	13	dep	_	_
31	HNF-1	hnf-1	NN	NN	_	33	compound	_	_
32	alpha	alpha	NN	NN	_	33	compound	_	_
33	dimers	dimer	NNS	NNS	_	30	dobj	_	_
34	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	formation	formation	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	a	a	DT	DT	_	9	det	_	_
5	stable	stable	JJ	JJ	_	9	amod	_	_
6	tetrameric	tetrameric	JJ	JJ	_	9	amod	_	_
7	DCoH-HNF-1	dcoh-hnf-1	NN	NN	_	9	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	2	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	required	require	VBD	VBD	_	2	acl:relcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	dimerization	dimerization	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	HNF-1	hnf-1	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	change	change	VB	VB	_	0	root	_	_
23	the	the	DT	DT	_	26	det	_	_
24	DNA	dna	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	characteristics	characteristic	NNS	NNS	_	22	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	HNF-1	hnf-1	NN	NN	_	29	compound	_	_
29	alpha	alpha	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	22	punct	_	_
31	but	but	CC	CC	_	22	cc	_	_
32	enhanced	enhance	VBD	VBD	_	22	conj	_	_
33	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
34	transcriptional	transcriptional	JJ	JJ	_	35	amod	_	_
35	activity	activity	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	22	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	DCoH	dcoh	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	confer	confer	VB	VB	_	0	root	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	GAL4	gal4	NN	NN	_	14	compound	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	DCoH	dcoh	NN	NN	_	6	nsubj	_	_
6	regulates	regulate	VBZ	VBZ	_	3	ccomp	_	_
7	formation	formation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	transcriptionally	transcriptionally	RB	RB	_	10	advmod	_	_
10	active	active	JJ	JJ	_	12	amod	_	_
11	tetrameric	tetrameric	JJ	JJ	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	contribute	contribute	VB	VB	_	6	conj	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	developmental	developmental	JJ	JJ	_	19	amod	_	_
19	specificity	specificity	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	complex	complex	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	High	high	JJ	JJ	_	3	amod	_	_
2	affinity	affinity	NN	NN	_	3	compound	_	_
3	aldosterone	aldosterone	NN	NN	_	0	root	_	_
4	binding	bind	VBG	VBG	_	3	acl	_	_
5	to	to	TO	TO	_	9	case	_	_
6	plasma	plasma	NN	NN	_	9	compound	_	_
7	membrane	membrane	NN	NN	_	9	compound	_	_
8	rich	rich	JJ	JJ	_	9	amod	_	_
9	fractions	fraction	NNS	NNS	_	4	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	9	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	is	be	VBZ	VBZ	_	3	parataxis	_	_
15	there	there	EX	EX	_	14	expl	_	_
16	a	a	DT	DT	_	18	det	_	_
17	membrane	membrane	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	14	nsubj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	mineralocorticoids	mineralocorticoid	NNS	NNS	_	18	nmod	_	_
21	?	?	.	.	_	14	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	effects	effect	NNS	NNS	_	24	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	aldosterone	aldosterone	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	concentrations	concentration	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	sodium	sodium	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	potassium	potassium	NN	NN	_	11	conj	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	calcium	calcium	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	3	punct	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	volume	volume	NN	NN	_	3	conj	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	sodium-proton-antiport	sodium-proton-antiport	NN	NN	_	3	conj	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	described	describe	VBN	VBN	_	0	root	_	_
25	in	in	IN	IN	_	29	case	_	_
26	intact	intact	JJ	JJ	_	29	amod	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	mononuclear	mononuclear	JJ	JJ	_	29	amod	_	_
29	leukocytes	leukocyte	NNS	NNS	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	HML	hml	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	paper	paper	NN	NN	_	21	nmod	_	_
5	,	,	,	,	_	21	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	21	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	-LSB-125I-RSB--labeled	-lsb-125i-rsb--labeled	JJ	JJ	_	11	amod	_	_
11	aldosterone	aldosterone	NN	NN	_	7	nmod	_	_
12	derivative	derivative	JJ	JJ	_	11	amod	_	_
13	to	to	TO	TO	_	17	case	_	_
14	plasma	plasma	NN	NN	_	15	compound	_	_
15	membrane	membrane	NN	NN	_	16	nmod:npmod	_	_
16	rich	rich	JJ	JJ	_	17	amod	_	_
17	fractions	fraction	NNS	NNS	_	7	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HML	hml	NN	NN	_	17	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	studied	study	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	High	high	JJ	JJ	_	3	amod	_	_
2	affinity	affinity	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	16	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	radioligand	radioligand	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	apparent	apparent	JJ	JJ	_	10	amod	_	_
10	Kd	kd	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	0.1	0.1	CD	CD	_	14	nummod	_	_
14	nM	nm	NN	NN	_	10	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	found	find	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Aldosterone	aldosterone	NN	NN	_	2	nsubj	_	_
2	displaced	displace	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	tracer	tracer	NN	NN	_	2	dobj	_	_
5	at	at	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	similar	similar	JJ	JJ	_	8	amod	_	_
8	Kd	kd	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	canrenone	canrenone	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cortisol	cortisol	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	inactive	inactive	JJ	JJ	_	0	root	_	_
7	as	as	IN	IN	_	8	case	_	_
8	ligands	ligand	NNS	NNS	_	6	nmod	_	_
9	up	up	RB	RB	_	11	advmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	concentrations	concentration	NNS	NNS	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	0.1	0.1	CD	CD	_	14	nummod	_	_
14	microM	microm	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	membrane	membrane	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	7	dobj	_	_
11	with	with	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	affinity	affinity	NN	NN	_	10	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	aldosterone	aldosterone	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	but	but	CC	CC	_	16	cc	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	for	for	IN	IN	_	21	case	_	_
21	cortisol	cortisol	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	perfectly	perfectly	RB	RB	_	5	advmod	_	_
5	compatible	compatible	JJ	JJ	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	major	major	JJ	JJ	_	8	amod	_	_
8	properties	property	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	steroidal	steroidal	JJ	JJ	_	11	amod	_	_
11	effects	effect	NNS	NNS	_	8	nmod	_	_
12	on	on	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	sodium-proton-antiport	sodium-proton-antiport	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	HML	hml	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	thus	thus	RB	RB	_	5	advmod	_	_
19	very	very	RB	RB	_	20	advmod	_	_
20	likely	likely	RB	RB	_	21	advmod	_	_
21	represent	represent	VBP	VBP	_	5	dep	_	_
22	membrane	membrane	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	21	dobj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	aldosterone	aldosterone	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	requirements	requirement	NNS	NNS	_	0	root	_	_
4	for	for	IN	IN	_	8	case	_	_
5	U2	u2	NN	NN	_	6	nmod:npmod	_	_
6	snRNA-encoding	snrna-encoding	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Transcription	transcription	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	13	case	_	_
3	a	a	DT	DT	_	13	det	_	_
4	human	human	JJ	JJ	_	13	amod	_	_
5	U2	u2	NN	NN	_	12	nmod:npmod	_	_
6	small	small	JJ	JJ	_	12	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
8	RNA	rna	NN	NN	_	12	nmod:npmod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	snRNA	snrna	NN	NN	_	12	nmod:npmod	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	-encoding	-encoding	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	1	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HeLa	hela	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	requires	require	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	21	det	_	_
19	distal	distal	JJ	JJ	_	21	amod	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	17	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	which	which	WDT	WDT	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	composed	compose	VBN	VBN	_	21	acl:relcl	_	_
26	of	of	IN	IN	_	29	case	_	_
27	one	one	CD	CD	_	29	nummod	_	_
28	octamer	octamer	NN	NN	_	29	compound	_	_
29	motif	motif	NN	NN	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	Oct	oct	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	three	three	CD	CD	_	37	nummod	_	_
35	Sp	sp	NN	NN	_	36	nmod:npmod	_	_
36	1-binding	1-binding	JJ	JJ	_	37	amod	_	_
37	sites	site	NNS	NNS	_	29	conj	_	_
38	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	15	advcl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	requirement	requirement	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	B-cells	b-cell	NNS	NNS	_	6	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	different	different	JJ	JJ	_	13	amod	_	_
11	U2	u2	NN	NN	_	13	compound	_	_
12	enhancer	enhancer	NN	NN	_	13	compound	_	_
13	constructions	construction	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	transfected	transfect	VBN	VBN	_	0	root	_	_
16	into	into	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	lymphoid	lymphoid	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	BJA-B	bja-b	NN	NN	_	20	appos	_	_
23	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	U2	u2	NN	NN	_	10	compound	_	_
9	snRNA	snrna	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	B-cells	b-cell	NNS	NNS	_	6	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	requires	require	VBZ	VBZ	_	3	ccomp	_	_
15	an	a	DT	DT	_	16	det	_	_
16	enhancer	enhancer	NN	NN	_	14	dobj	_	_
17	comprising	comprise	VBG	VBG	_	16	acl	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	Oct	oct	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	at	at	IN	IN	_	23	case	_	_
23	least	least	JJS	JJS	_	24	nmod:npmod	_	_
24	one	one	CD	CD	_	27	nummod	_	_
25	Sp	sp	NN	NN	_	26	nmod:npmod	_	_
26	1-binding	1-binding	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	20	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Deletion	deletion	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	all	all	PDT	PDT	_	7	det:predet	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Sp	sp	NN	NN	_	6	nmod:npmod	_	_
6	1-binding	1-binding	JJ	JJ	_	7	amod	_	_
7	sites	site	NNS	NNS	_	1	nmod	_	_
8	from	from	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	enhancer	enhancer	NN	NN	_	1	nmod	_	_
11	reduces	reduce	VBZ	VBZ	_	0	root	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	80-90	80-90	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	HeLa	hela	NN	NN	_	24	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	as	as	RB	RB	_	17	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	in	in	IN	IN	_	23	case	_	_
23	BJA-B	bja-b	NN	NN	_	17	conj	_	_
24	cells	cell	NNS	NNS	_	11	nmod	_	_
25	,	,	,	,	_	11	punct	_	_
26	whereas	whereas	IN	IN	_	11	dep	_	_
27	the	the	DT	DT	_	28	det	_	_
28	removal	removal	NN	NN	_	33	nsubj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	octamer-binding	octamer-binding	JJ	JJ	_	32	amod	_	_
32	site	site	NN	NN	_	28	nmod	_	_
33	reduces	reduce	VBZ	VBZ	_	11	parataxis	_	_
34	transcription	transcription	NN	NN	_	33	dobj	_	_
35	to	to	TO	TO	_	36	case	_	_
36	levels	level	NNS	NNS	_	33	nmod	_	_
37	below	below	IN	IN	_	38	case	_	_
38	detection	detection	NN	NN	_	36	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	both	both	DT	DT	_	42	det	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	types	type	NNS	NNS	_	33	nmod	_	_
43	.	.	.	.	_	11	punct	_	_

1	Enhancers	enhancer	NNS	NNS	_	6	nsubj	_	_
2	containing	contain	VBG	VBG	_	1	acl	_	_
3	a	a	DT	DT	_	5	det	_	_
4	single	single	JJ	JJ	_	5	amod	_	_
5	Oct	oct	NN	NN	_	2	dobj	_	_
6	have	have	VBP	VBP	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	nevertheless	nevertheless	RB	RB	_	6	advmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	capacity	capacity	NN	NN	_	6	dobj	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	partially	partially	RB	RB	_	14	advmod	_	_
14	activate	activate	VB	VB	_	11	acl	_	_
15	U2	u2	NN	NN	_	17	compound	_	_
16	snRNA	snrna	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	both	both	DT	DT	_	21	det	_	_
20	HeLa	hela	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	6	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	in	in	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	28	nmod	_	_
25	only	only	RB	RB	_	26	advmod	_	_
26	OTF-1	otf-1	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	expressed	express	VBN	VBN	_	21	acl:relcl	_	_
29	,	,	,	,	_	21	punct	_	_
30	and	and	CC	CC	_	21	cc	_	_
31	in	in	IN	IN	_	33	case	_	_
32	BJA-B	bja-b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	21	conj	_	_
34	in	in	IN	IN	_	35	case	_	_
35	which	which	WDT	WDT	_	42	nmod	_	_
36	OTF-2	otf-2	NN	NN	_	42	nsubj	_	_
37	is	be	VBZ	VBZ	_	42	cop	_	_
38	the	the	DT	DT	_	42	det	_	_
39	predominantly	predominantly	RB	RB	_	40	advmod	_	_
40	expressed	express	VBN	VBN	_	42	amod	_	_
41	octamer-binding	octamer-binding	JJ	JJ	_	42	amod	_	_
42	factor	factor	NN	NN	_	33	acl:relcl	_	_
43	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	most	most	RBS	RBS	_	3	advmod	_	_
3	likely	likely	JJ	JJ	_	4	amod	_	_
4	interpretation	interpretation	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
7	results	result	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	27	mark	_	_
10	both	both	CC	CC	_	14	cc:preconj	_	_
11	the	the	DT	DT	_	14	det	_	_
12	ubiquitous	ubiquitous	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	27	nsubj	_	_
15	,	,	,	,	_	14	punct	_	_
16	OTF-1	otf-1	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	B-cell-specific	b-cell-specific	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	14	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	OTF-2	otf-2	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	22	punct	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	activate	activate	VB	VB	_	8	ccomp	_	_
28	U2	u2	NN	NN	_	30	compound	_	_
29	snRNA	snrna	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	similar	similar	JJ	JJ	_	8	amod	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	cooperation	cooperation	NN	NN	_	4	dobj	_	_
9	between	between	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	bind	bind	VBP	VBP	_	12	acl:relcl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	Oct	oct	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	adjacent	adjacent	JJ	JJ	_	22	amod	_	_
21	Sp	sp	NN	NN	_	22	nmod:npmod	_	_
22	1-binding	1-binding	JJ	JJ	_	17	conj	_	_
23	site	site	NN	NN	_	17	dep	_	_
24	in	in	IN	IN	_	26	case	_	_
25	BJA-B	bja-b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	14	nmod	_	_
27	,	,	,	,	_	14	punct	_	_
28	as	as	IN	IN	_	31	mark	_	_
29	has	have	VBZ	VBZ	_	31	aux	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	observed	observe	VBN	VBN	_	14	advcl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	HeLa	hela	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	4	punct	_	_
36	since	since	IN	IN	_	47	mark	_	_
37	a	a	DT	DT	_	38	det	_	_
38	template	template	NN	NN	_	47	nsubj	_	_
39	which	which	WDT	WDT	_	40	nsubj	_	_
40	contains	contain	VBZ	VBZ	_	38	acl:relcl	_	_
41	a	a	DT	DT	_	44	det	_	_
42	weak	weak	JJ	JJ	_	44	amod	_	_
43	binding	bind	VBG	VBG	_	44	amod	_	_
44	site	site	NN	NN	_	40	dobj	_	_
45	for	for	IN	IN	_	46	case	_	_
46	OTFs	otf	NNS	NNS	_	44	nmod	_	_
47	expresses	express	VBZ	VBZ	_	4	advcl	_	_
48	wild-type	wild-type	JJ	JJ	_	49	amod	_	_
49	levels	level	NNS	NNS	_	47	dobj	_	_
50	of	of	IN	IN	_	52	case	_	_
51	U2	u2	NN	NN	_	52	compound	_	_
52	snRNA	snrna	NN	NN	_	49	nmod	_	_
53	in	in	IN	IN	_	56	case	_	_
54	both	both	DT	DT	_	56	det	_	_
55	cell	cell	NN	NN	_	56	compound	_	_
56	types	type	NNS	NNS	_	47	nmod	_	_
57	when	when	WRB	WRB	_	63	advmod	_	_
58	the	the	DT	DT	_	61	det	_	_
59	weak	weak	JJ	JJ	_	61	amod	_	_
60	octamer-binding	octamer-binding	JJ	JJ	_	61	amod	_	_
61	site	site	NN	NN	_	63	nsubjpass	_	_
62	is	be	VBZ	VBZ	_	63	auxpass	_	_
63	combined	combine	VBN	VBN	_	47	advcl	_	_
64	with	with	IN	IN	_	68	case	_	_
65	a	a	DT	DT	_	68	det	_	_
66	Sp	sp	NN	NN	_	67	nmod:npmod	_	_
67	1-binding	1-binding	JJ	JJ	_	68	amod	_	_
68	site	site	NN	NN	_	63	nmod	_	_
69	.	.	.	.	_	4	punct	_	_

1	Cortisol	cortisol	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	resistance	resistance	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	variability	variability	NN	NN	_	3	dep	_	_
7	of	of	IN	IN	_	10	case	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	clinical	clinical	JJ	JJ	_	10	amod	_	_
10	presentation	presentation	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	response	response	NN	NN	_	10	conj	_	_
13	to	to	TO	TO	_	14	case	_	_
14	treatment	treatment	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Primary	primary	JJ	JJ	_	7	amod	_	_
2	(	(	-LRB-	-LRB-	_	7	punct	_	_
3	partial	partial	JJ	JJ	_	7	amod	_	_
4	)	)	-RRB-	-RRB-	_	7	punct	_	_
5	cortisol	cortisol	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	resistance	resistance	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	reported	report	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	total	total	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	7	7	CD	CD	_	16	nummod	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	14	14	CD	CD	_	21	nummod	_	_
19	asymptomatic	asymptomatic	JJ	JJ	_	21	amod	_	_
20	family	family	NN	NN	_	21	compound	_	_
21	members	member	NNS	NNS	_	16	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	occurrence	occurrence	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	considered	consider	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	extremely	extremely	RB	RB	_	8	advmod	_	_
8	rare	rare	JJ	JJ	_	4	xcomp	_	_
9	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	report	report	VBP	VBP	_	0	root	_	_
7	on	on	IN	IN	_	9	case	_	_
8	6	6	CD	CD	_	9	nummod	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	2	2	CD	CD	_	12	nummod	_	_
12	males	male	NNS	NNS	_	9	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	4	4	CD	CD	_	15	nummod	_	_
15	females	female	NNS	NNS	_	12	conj	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	syndrome	syndrome	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	first	first	JJ	JJ	_	4	amod	_	_
3	male	male	JJ	JJ	_	4	amod	_	_
4	patient	patient	NN	NN	_	5	nsubj	_	_
5	presented	present	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	mild	mild	JJ	JJ	_	8	amod	_	_
8	hypertension	hypertension	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	Hydrochlorothiazide	hydrochlorothiazide	NN	NN	_	2	compound	_	_
2	therapy	therapy	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	life-threatening	life-threatening	JJ	JJ	_	6	amod	_	_
6	hypokalemia	hypokalemia	NN	NN	_	3	nmod	_	_
7	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	second	second	JJ	JJ	_	4	amod	_	_
3	male	male	JJ	JJ	_	4	amod	_	_
4	patient	patient	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	slight	slight	JJ	JJ	_	7	amod	_	_
7	hypertension	hypertension	NN	NN	_	5	dobj	_	_
8	without	without	IN	IN	_	9	case	_	_
9	hypokalemia	hypokalemia	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	4	det	_	_
2	four	four	CD	CD	_	4	nummod	_	_
3	female	female	JJ	JJ	_	4	amod	_	_
4	patients	patient	NNS	NNS	_	5	nsubj	_	_
5	presented	present	VBD	VBD	_	0	root	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	age	age	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	20-30	20-30	CD	CD	_	11	nummod	_	_
11	yr	yr	NN	NN	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	acne	acne	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	hirsutism	hirsutism	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	irregular	irregular	JJ	JJ	_	19	amod	_	_
19	menstruations	menstruation	NNS	NNS	_	13	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Low	low	JJ	JJ	_	4	amod	_	_
2	dose	dose	NN	NN	_	4	compound	_	_
3	dexamethasone	dexamethasone	NN	NN	_	4	compound	_	_
4	therapy	therapy	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	1-1.5	1-1.5	CD	CD	_	7	nummod	_	_
7	mg/day	mg/day	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	was	be	VBD	VBD	_	12	cop	_	_
10	of	of	IN	IN	_	12	case	_	_
11	clinical	clinical	JJ	JJ	_	12	amod	_	_
12	benefit	benefit	NN	NN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	insufficient	insufficient	JJ	JJ	_	5	amod	_	_
5	suppression	suppression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	serum	serum	NN	NN	_	9	compound	_	_
8	cortisol	cortisol	NN	NN	_	9	compound	_	_
9	concentrations	concentration	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	overnight	overnight	JJ	JJ	_	15	amod	_	_
13	1-mg	1-mg	JJ	JJ	_	15	amod	_	_
14	dexamethasone	dexamethasone	NN	NN	_	15	compound	_	_
15	test	test	NN	NN	_	3	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	diurnal	diurnal	JJ	JJ	_	3	amod	_	_
3	rhythm	rhythm	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	ACTH	acth	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cortisol	cortisol	NN	NN	_	5	conj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	intact	intact	JJ	JJ	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	albeit	albeit	IN	IN	_	15	case	_	_
12	at	at	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	elevated	elevated	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	9	advcl	_	_
16	.	.	.	.	_	9	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	normal	normal	JJ	JJ	_	5	amod	_	_
5	increase	increase	NN	NN	_	2	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	ACTH	acth	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	cortisol	cortisol	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	GH	gh	NN	NN	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	2	punct	_	_
14	except	except	IN	IN	_	18	case	_	_
15	in	in	IN	IN	_	18	case	_	_
16	one	one	CD	CD	_	18	nummod	_	_
17	obese	obese	JJ	JJ	_	18	amod	_	_
18	patient	patient	NN	NN	_	2	advcl	_	_
19	)	)	-RRB-	-RRB-	_	2	punct	_	_
20	in	in	IN	IN	_	24	case	_	_
21	response	response	NN	NN	_	24	dep	_	_
22	to	to	TO	TO	_	24	case	_	_
23	insulin-induced	insulin-induced	JJ	JJ	_	24	amod	_	_
24	hypoglycemia	hypoglycemia	NN	NN	_	2	nmod	_	_
25	,	,	,	,	_	2	punct	_	_
26	while	while	IN	IN	_	30	mark	_	_
27	cortisol	cortisol	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	30	nsubj	_	_
29	was	be	VBD	VBD	_	30	aux	_	_
30	elevated	elevated	JJ	JJ	_	2	advcl	_	_
31	in	in	IN	IN	_	33	case	_	_
32	three	three	CD	CD	_	33	nummod	_	_
33	patients	patient	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Circulating	circulate	VBG	VBG	_	4	amod	_	_
2	adrenal	adrenal	JJ	JJ	_	4	amod	_	_
3	androgen	androgen	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	increased	increase	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	whole	whole	JJ	JJ	_	11	amod	_	_
8	cell	cell	NN	NN	_	11	compound	_	_
9	dexamethasone	dexamethasone	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	assay	assay	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	first	first	JJ	JJ	_	5	amod	_	_
4	male	male	JJ	JJ	_	5	amod	_	_
5	patient	patient	NN	NN	_	13	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	receptors	receptor	NNS	NNS	_	8	nmod	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	low	low	JJ	JJ	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	while	while	IN	IN	_	19	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	affinity	affinity	NN	NN	_	19	nsubj	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	lower	lower	JJR	JJR	_	13	advcl	_	_
20	than	than	IN	IN	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	controls	control	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	lowered	lowered	JJ	JJ	_	3	amod	_	_
3	affinity	affinity	NN	NN	_	7	nsubjpass	_	_
4	to	to	TO	TO	_	5	case	_	_
5	dexamethasone	dexamethasone	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	one	one	CD	CD	_	11	nummod	_	_
10	female	female	JJ	JJ	_	11	amod	_	_
11	patient	patient	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	while	while	IN	IN	_	20	mark	_	_
14	a	a	DT	DT	_	16	det	_	_
15	lowered	lowered	JJ	JJ	_	16	amod	_	_
16	number	number	NN	NN	_	20	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	receptors	receptor	NNS	NNS	_	16	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	7	advcl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	three	three	CD	CD	_	23	nummod	_	_
23	patients	patient	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	second	second	JJ	JJ	_	5	amod	_	_
4	male	male	JJ	JJ	_	5	amod	_	_
5	patient	patient	NN	NN	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	abnormalities	abnormality	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	bioassay	bioassay	NN	NN	_	9	nmod	_	_
4	for	for	IN	IN	_	6	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	action	action	NN	NN	_	3	nmod	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	measured	measure	VBD	VBD	_	0	root	_	_
10	dexamethasone	dexamethasone	NN	NN	_	11	compound	_	_
11	suppressibility	suppressibility	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	mitogen-stimulated	mitogen-stimulated	JJ	JJ	_	14	amod	_	_
14	incorporation	incorporation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	mononuclear	mononuclear	JJ	JJ	_	19	amod	_	_
19	leukocytes	leukocyte	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	male	male	JJ	JJ	_	4	amod	_	_
4	patient	patient	NN	NN	_	17	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	status	status	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	dexamethasone	dexamethasone	NN	NN	_	11	compound	_	_
11	suppressibility	suppressibility	NN	NN	_	17	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	14	compound	_	_
14	incorporation	incorporation	NN	NN	_	11	nmod	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	lower	lower	JJR	JJR	_	0	root	_	_
18	than	than	IN	IN	_	19	case	_	_
19	that	that	DT	DT	_	17	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	healthy	healthy	JJ	JJ	_	22	amod	_	_
22	controls	control	NNS	NNS	_	19	nmod	_	_
23	with	with	IN	IN	_	28	case	_	_
24	respect	respect	NN	NN	_	28	dep	_	_
25	to	to	TO	TO	_	28	case	_	_
26	both	both	CC	CC	_	28	cc:preconj	_	_
27	maximal	maximal	JJ	JJ	_	28	amod	_	_
28	suppression	suppression	NN	NN	_	17	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	IC50	ic50	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	Partial	partial	JJ	JJ	_	4	amod	_	_
2	cortisol	cortisol	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	resistance	resistance	NN	NN	_	8	nsubj	_	_
5	might	might	MD	MD	_	8	aux	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	less	less	RBR	RBR	_	8	advmod	_	_
8	rare	rare	JJ	JJ	_	0	root	_	_
9	than	than	IN	IN	_	11	mark	_	_
10	previously	previously	RB	RB	_	11	advmod	_	_
11	thought	think	VBN	VBN	_	8	dep	_	_
12	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	six	six	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	14	nmod	_	_
5	presented	present	VBN	VBN	_	4	acl	_	_
6	,	,	,	,	_	14	punct	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	forms	form	NNS	NNS	_	14	nsubjpass	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	recognized	recognize	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Therapy	therapy	NN	NN	_	5	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	successful	successful	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	female	female	JJ	JJ	_	8	amod	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	acne	acne	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	hirsutism	hirsutism	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	as	as	IN	IN	_	26	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	secondary	secondary	JJ	JJ	_	17	amod	_	_
17	increase	increase	NN	NN	_	26	nsubjpass	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	production	production	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	adrenal	adrenal	JJ	JJ	_	23	amod	_	_
23	androgens	androgen	NNS	NNS	_	20	nmod	_	_
24	was	be	VBD	VBD	_	26	auxpass	_	_
25	effectively	effectively	RB	RB	_	26	advmod	_	_
26	controlled	control	VBN	VBN	_	5	advcl	_	_
27	.	.	.	.	_	5	punct	_	_

1	Kappa	kappa	NN	NN	_	2	nmod:npmod	_	_
2	B-specific	b-specific	JJ	JJ	_	5	amod	_	_
3	DNA	dna	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	8	nsubjpass	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	differentially	differentially	RB	RB	_	8	advmod	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	mutations	mutation	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	biological	biological	JJ	JJ	_	14	amod	_	_
14	oxidation	oxidation	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	8	punct	_	_

1	Kappa	kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	9	compound	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	enhancer	enhancer	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	19	nsubj	_	_
10	isolated	isolate	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	activated	activate	VBN	VBN	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	produce	produce	VBP	VBP	_	0	root	_	_
20	two	two	CD	CD	_	23	nummod	_	_
21	distinct	distinct	JJ	JJ	_	23	amod	_	_
22	nucleoprotein	nucleoprotein	NN	NN	_	23	compound	_	_
23	complexes	complex	NNS	NNS	_	19	dobj	_	_
24	when	when	WRB	WRB	_	25	advmod	_	_
25	incubated	incubate	VBN	VBN	_	19	advcl	_	_
26	with	with	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	element	element	NN	NN	_	25	nmod	_	_
31	from	from	IN	IN	_	39	case	_	_
32	the	the	DT	DT	_	39	det	_	_
33	interleukin-2	interleukin-2	NN	NN	_	34	compound	_	_
34	receptor-alpha	receptor-alpha	NN	NN	_	39	compound	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	IL-2R	il-2r	NN	NN	_	37	compound	_	_
37	alpha	alpha	NN	NN	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	gene	gene	NN	NN	_	30	nmod	_	_
40	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	DNA-protein	dna-protein	JJ	JJ	_	4	amod	_	_
4	complexes	complex	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	composed	compose	VBN	VBN	_	0	root	_	_
7	of	of	IN	IN	_	12	case	_	_
8	at	at	IN	IN	_	9	case	_	_
9	least	least	JJS	JJS	_	10	nmod:npmod	_	_
10	four	four	CD	CD	_	12	nummod	_	_
11	host	host	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	p50	p50	NN	NN	_	12	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	p55	p55	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	p75	p75	NN	NN	_	14	appos	_	_
19	,	,	,	,	_	14	punct	_	_
20	p85	p85	NN	NN	_	14	appos	_	_
21	)	)	-RRB-	-RRB-	_	14	punct	_	_
22	,	,	,	,	_	12	punct	_	_
23	each	each	DT	DT	_	26	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	which	which	WDT	WDT	_	23	nmod	_	_
26	shares	share	VBZ	VBZ	_	12	acl:relcl	_	_
27	structural	structural	JJ	JJ	_	28	amod	_	_
28	similarity	similarity	NN	NN	_	26	dobj	_	_
29	with	with	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	v-rel	v-rel	NN	NN	_	33	compound	_	_
32	oncogene	oncogene	NN	NN	_	33	compound	_	_
33	product	product	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	distinctly	distinctly	RB	RB	_	10	advmod	_	_
10	biphasic	biphasic	JJ	JJ	_	11	amod	_	_
11	kinetics	kinetics	NNS	NNS	_	7	nmod	_	_
12	following	follow	VBG	VBG	_	15	case	_	_
13	phorbol	phorbol	NN	NN	_	15	compound	_	_
14	ester	ester	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	p55/p75	p55/p75	NN	NN	_	18	dep	_	_
21	early	early	JJ	JJ	_	20	amod	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	p50/p85	p50/p85	NN	NN	_	20	conj	_	_
24	late	late	JJ	JJ	_	23	amod	_	_
25	)	)	-RRB-	-RRB-	_	20	punct	_	_
26	.	.	.	.	_	7	punct	_	_

1	DNA-protein	dna-protein	JJ	JJ	_	3	amod	_	_
2	crosslinking	crosslinking	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	revealed	reveal	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	12	det	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	rapidly	rapidly	RB	RB	_	10	advmod	_	_
10	migrating	migrate	VBG	VBG	_	12	amod	_	_
11	B2	b2	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	13	nsubj	_	_
13	contains	contain	VBZ	VBZ	_	5	ccomp	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	p50	p50	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	p55	p55	NN	NN	_	15	conj	_	_
18	while	while	IN	IN	_	26	mark	_	_
19	the	the	DT	DT	_	24	det	_	_
20	more	more	RBR	RBR	_	21	advmod	_	_
21	slowly	slowly	RB	RB	_	22	advmod	_	_
22	migrating	migrate	VBG	VBG	_	24	amod	_	_
23	B1	b1	NN	NN	_	24	compound	_	_
24	complex	complex	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	composed	compose	VBN	VBN	_	13	advcl	_	_
27	of	of	IN	IN	_	28	case	_	_
28	p50	p50	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	p55	p55	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	p75	p75	NN	NN	_	28	conj	_	_
33	,	,	,	,	_	28	punct	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	p85	p85	NN	NN	_	28	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	wild-type	wild-type	JJ	JJ	_	10	amod	_	_
6	IL-2R	il-2r	NN	NN	_	10	compound	_	_
7	alpha	alpha	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	enhancer	enhancer	NN	NN	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	GGGGAATCTCCC	ggggaatctccc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	has	have	VBZ	VBZ	_	15	aux	_	_
15	revealed	reveal	VBN	VBN	_	0	root	_	_
16	that	that	IN	IN	_	29	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	binding	binding	NN	NN	_	29	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	p50	p50	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	p55	p55	NN	NN	_	20	conj	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	B2	b2	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	20	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	is	be	VBZ	VBZ	_	29	cop	_	_
28	particularly	particularly	RB	RB	_	29	advmod	_	_
29	sensitive	sensitive	JJ	JJ	_	15	ccomp	_	_
30	to	to	TO	TO	_	31	case	_	_
31	alteration	alteration	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	5'	5'	JJ	JJ	_	35	amod	_	_
35	triplet	triplet	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	deoxyguanosine	deoxyguanosine	NN	NN	_	38	compound	_	_
38	residues	residue	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	19	nmod	_	_
3	,	,	,	,	_	19	punct	_	_
4	formation	formation	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	B1	b1	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	reflecting	reflect	VBG	VBG	_	4	acl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	binding	binding	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	p75	p75	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	p85	p85	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	4	punct	_	_
18	critically	critically	RB	RB	_	19	advmod	_	_
19	depends	depend	VBZ	VBZ	_	0	root	_	_
20	upon	upon	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	more	more	RBR	RBR	_	24	advmod	_	_
23	3'	3'	JJ	JJ	_	24	amod	_	_
24	sequences	sequence	NNS	NNS	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	this	this	DT	DT	_	28	det	_	_
27	enhancer	enhancer	NN	NN	_	28	compound	_	_
28	element	element	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	19	punct	_	_

1	DNA	dna	NN	NN	_	2	compound	_	_
2	binding	binding	NN	NN	_	11	nsubjpass	_	_
3	by	by	IN	IN	_	5	case	_	_
4	all	all	DT	DT	_	5	det	_	_
5	four	four	CD	CD	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	these	these	DT	DT	_	9	det	_	_
8	Rel-related	rel-related	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	blocked	block	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	selective	selective	JJ	JJ	_	15	amod	_	_
14	chemical	chemical	JJ	JJ	_	15	amod	_	_
15	modification	modification	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	lysine	lysine	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	arginine	arginine	NN	NN	_	17	conj	_	_
20	residues	residue	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	11	punct	_	_
22	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
23	that	that	IN	IN	_	31	mark	_	_
24	both	both	DT	DT	_	31	nsubjpass	_	_
25	of	of	IN	IN	_	29	case	_	_
26	these	these	DT	DT	_	29	det	_	_
27	basic	basic	JJ	JJ	_	29	amod	_	_
28	amino	amino	NN	NN	_	29	compound	_	_
29	acids	acid	NNS	NNS	_	24	nmod	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	required	require	VBN	VBN	_	22	ccomp	_	_
32	for	for	IN	IN	_	33	mark	_	_
33	binding	bind	VBG	VBG	_	31	advcl	_	_
34	to	to	TO	TO	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	kappa	kappa	NN	NN	_	38	compound	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	element	element	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	Similarly	similarly	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	covalent	covalent	JJ	JJ	_	4	amod	_	_
4	modification	modification	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	free	free	JJ	JJ	_	8	amod	_	_
7	sulfhydryl	sulfhydryl	NN	NN	_	8	compound	_	_
8	groups	group	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	diamide	diamide	NN	NN	_	4	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	reversible	reversible	JJ	JJ	_	10	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	N-ethylmaleimide	n-ethylmaleimide	NN	NN	_	10	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	irreversible	irreversible	JJ	JJ	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	results	result	VBZ	VBZ	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	complete	complete	JJ	JJ	_	23	amod	_	_
23	loss	loss	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	DNA	dna	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	mild	mild	JJ	JJ	_	5	amod	_	_
5	oxidation	oxidation	NN	NN	_	10	nsubj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	glucose	glucose	NN	NN	_	8	compound	_	_
8	oxidase	oxidase	NN	NN	_	5	nmod	_	_
9	selectively	selectively	RB	RB	_	10	advmod	_	_
10	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
11	p75	p75	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p85	p85	NN	NN	_	11	conj	_	_
14	binding	binding	NN	NN	_	10	dobj	_	_
15	while	while	IN	IN	_	17	mark	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	blocking	block	VBG	VBG	_	10	advcl	_	_
18	p50	p50	NN	NN	_	21	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p55	p55	NN	NN	_	18	conj	_	_
21	interactions	interaction	NNS	NNS	_	17	dobj	_	_
22	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	reduced	reduce	VBN	VBN	_	7	amod	_	_
6	cysteine	cysteine	NN	NN	_	7	compound	_	_
7	thiols	thiol	NNS	NNS	_	8	nsubj	_	_
8	play	play	VBP	VBP	_	3	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	8	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	family	family	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	Rel-related	rel-related	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	mitogen-inducible	mitogen-inducible	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	10	nsubj	_	_
6	related	related	JJ	JJ	_	5	amod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	p50/p105-NF-kappa	p50/p105-nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	participates	participate	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	transactivation	transactivation	NN	NN	_	10	nmod	_	_
13	through	through	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	8	det	_	_
2	Rel-related	rel-related	JJ	JJ	_	8	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	mitogen-inducible	mitogen-inducible	JJ	JJ	_	2	dep	_	_
5	,	,	,	,	_	2	punct	_	_
6	kappa	kappa	NN	NN	_	7	nmod:npmod	_	_
7	B-binding	b-binding	JJ	JJ	_	2	dep	_	_
8	protein	protein	NN	NN	_	11	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	cloned	clone	VBN	VBN	_	0	root	_	_
12	as	as	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	immediate-early	immediate-early	JJ	JJ	_	16	amod	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
20	blood	blood	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cDNA	cdna	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	7	det	_	_
5	open	open	JJ	JJ	_	7	amod	_	_
6	reading	reading	NN	NN	_	7	compound	_	_
7	frame	frame	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	900	900	CD	CD	_	11	nummod	_	_
10	amino	amino	NN	NN	_	11	compound	_	_
11	acids	acid	NNS	NNS	_	7	nmod	_	_
12	capable	capable	JJ	JJ	_	7	amod	_	_
13	of	of	IN	IN	_	14	mark	_	_
14	encoding	encode	VBG	VBG	_	12	advcl	_	_
15	a	a	DT	DT	_	17	det	_	_
16	97-kDa	97-kda	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	similar	similar	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	105-kDa	105-kda	JJ	JJ	_	10	amod	_	_
9	precursor	precursor	NN	NN	_	10	compound	_	_
10	polypeptide	polypeptide	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	p50-NF-kappa	p50-nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Like	like	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	105-kDa	105-kda	JJ	JJ	_	4	amod	_	_
4	precursor	precursor	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	it	it	PRP	PRP	_	7	nsubj	_	_
7	contains	contain	VBZ	VBZ	_	0	root	_	_
8	an	a	DT	DT	_	11	det	_	_
9	amino-terminal	amino-terminal	JJ	JJ	_	11	amod	_	_
10	Rel-related	rel-related	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	about	about	IN	IN	_	14	advmod	_	_
14	300	300	CD	CD	_	16	nummod	_	_
15	amino	amino	NN	NN	_	16	compound	_	_
16	acids	acid	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	carboxy-terminal	carboxy-terminal	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	11	conj	_	_
21	containing	contain	VBG	VBG	_	20	acl	_	_
22	six	six	CD	CD	_	28	nummod	_	_
23	full	full	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	cycle	cycle	NN	NN	_	28	compound	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	ankyrin	ankyrin	NN	NN	_	25	conj	_	_
28	repeats	repeat	NNS	NNS	_	21	dobj	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	FW	FW	_	2	dep	_	_
2	vitro-translated	vitro-translated	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	truncated	truncate	VBN	VBN	_	3	dep	_	_
6	downstream	downstream	RB	RB	_	5	advmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Rel	rel	NN	NN	_	10	compound	_	_
10	domain	domain	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	excluding	exclude	VBG	VBG	_	5	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	repeats	repeat	NNS	NNS	_	12	dobj	_	_
15	,	,	,	,	_	3	punct	_	_
16	bind	bind	VBP	VBP	_	0	root	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	refer	refer	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	kappa	kappa	NN	NN	_	6	nmod:npmod	_	_
6	B-binding	b-binding	JJ	JJ	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	truncated	truncate	VBN	VBN	_	9	amod	_	_
9	protein	protein	NN	NN	_	6	appos	_	_
10	as	as	IN	IN	_	11	case	_	_
11	p50B	p50b	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	analogy	analogy	NN	NN	_	9	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	p50-NF-kappa	p50-nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	full-length	full-length	JJ	JJ	_	21	amod	_	_
21	protein	protein	NN	NN	_	6	conj	_	_
22	as	as	IN	IN	_	23	case	_	_
23	p97	p97	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	p50B	p50b	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	able	able	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	form	form	VB	VB	_	3	xcomp	_	_
6	heteromeric	heteromeric	JJ	JJ	_	9	amod	_	_
7	kappa	kappa	NN	NN	_	8	nmod:npmod	_	_
8	B-binding	b-binding	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	5	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	RelB	relb	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	RB	RB	_	11	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	with	with	IN	IN	_	17	case	_	_
17	p65	p65	NN	NN	_	11	conj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	p50	p50	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	the	the	DT	DT	_	23	det	_	_
22	two	two	CD	CD	_	23	nummod	_	_
23	subunits	subunit	NNS	NNS	_	17	appos	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Transient-transfection	transient-transfection	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	embryonal	embryonal	JJ	JJ	_	6	amod	_	_
5	carcinoma	carcinoma	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	cooperation	cooperation	NN	NN	_	7	dobj	_	_
11	between	between	IN	IN	_	12	case	_	_
12	p50B	p50b	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	RelB	relb	NN	NN	_	12	conj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	p65	p65	NN	NN	_	14	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	transactivation	transactivation	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	reporter	reporter	NN	NN	_	22	compound	_	_
22	plasmid	plasmid	NN	NN	_	18	nmod	_	_
23	dependent	dependent	JJ	JJ	_	18	amod	_	_
24	on	on	IN	IN	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	kappa	kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	existence	existence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	complex	complex	JJ	JJ	_	9	amod	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	nmod:npmod	_	_
12	B-like	b-like	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Changes	change	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	leucocytic	leucocytic	JJ	JJ	_	7	amod	_	_
5	estrogen	estrogen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	climacteric	climacteric	JJ	JJ	_	12	amod	_	_
12	syndrome	syndrome	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	therapeutic	therapeutic	JJ	JJ	_	15	amod	_	_
15	effect	effect	NN	NN	_	2	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	liuwei	liuwei	FW	FW	_	19	compound	_	_
18	dihuang	dihuang	FW	FW	_	19	compound	_	_
19	pills	pill	NNS	NNS	_	15	nmod	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	numbers	number	NNS	NNS	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	estrogen	estrogen	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ER	er	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	leucocytes	leucocyte	NNS	NNS	_	5	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	22	22	CD	CD	_	15	nummod	_	_
15	women	woman	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	climacteric	climacteric	JJ	JJ	_	18	amod	_	_
18	syndrome	syndrome	NN	NN	_	15	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	measured	measure	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	radioligand	radioligand	NN	NN	_	23	compound	_	_
23	method	method	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	compared	compare	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	those	those	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	12	12	CD	CD	_	11	nummod	_	_
9	normal	normal	JJ	JJ	_	11	amod	_	_
10	child-bearing-age	child-bearing-age	JJ	JJ	_	11	amod	_	_
11	women	woman	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	wat	wat	VBD	VBD	_	0	root	_	_
3	found	find	VBN	VBN	_	2	dep	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	contents	contents	NNS	NNS	_	16	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	leucocytic	leucocytic	JJ	JJ	_	9	amod	_	_
9	ER	er	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	climacteric	climacteric	JJ	JJ	_	13	amod	_	_
12	syndrome	syndrome	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	9	nmod	_	_
14	were	be	VBD	VBD	_	16	cop	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	lower	lower	JJR	JJR	_	3	ccomp	_	_
17	than	than	IN	IN	_	20	case	_	_
18	normal	normal	JJ	JJ	_	20	amod	_	_
19	child-bearing-age	child-bearing-age	JJ	JJ	_	20	amod	_	_
20	women	woman	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	3	nsubj	_	_
3	used	use	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	Chinese	chinese	JJ	JJ	_	6	amod	_	_
6	prescription	prescription	NN	NN	_	3	dobj	_	_
7	--	--	:	:	_	6	punct	_	_
8	Liuwei	liuwei	FW	FW	_	10	compound	_	_
9	Dihuang	dihuang	FW	FW	_	10	compound	_	_
10	Pills	pill	NNS	NNS	_	6	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	LDP	ldp	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	treat	treat	VB	VB	_	3	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	patients	patient	NNS	NNS	_	15	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	2	2	CD	CD	_	20	nummod	_	_
20	months	month	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	numbers	number	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	leucocytic	leucocytic	JJ	JJ	_	5	amod	_	_
5	ER	er	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	after	after	IN	IN	_	10	case	_	_
10	treatment	treatment	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	decrease	decrease	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	ER	er	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	cell	cell	NN	NN	_	8	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	involve	involve	VB	VB	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	pathogenesis	pathogenesis	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	climacteric	climacteric	JJ	JJ	_	18	amod	_	_
18	syndrome	syndrome	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	LDP	ldp	NN	NN	_	4	nsubj	_	_
2	not	not	RB	RB	_	3	neg	_	_
3	only	only	RB	RB	_	4	cc:preconj	_	_
4	increases	increase	VBZ	VBZ	_	0	root	_	_
5	plasma	plasma	NN	NN	_	7	compound	_	_
6	estradiol	estradiol	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	4	dobj	_	_
8	,	,	,	,	_	4	punct	_	_
9	but	but	CC	CC	_	4	cc	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	increases	increase	VBZ	VBZ	_	4	conj	_	_
12	the	the	DT	DT	_	15	det	_	_
13	leucocytic	leucocytic	JJ	JJ	_	15	amod	_	_
14	ER	er	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	11	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	may	may	MD	MD	_	5	aux	_	_
3	be	be	VB	VB	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	basis	basis	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	therapeutic	therapeutic	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	5	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	disease	disease	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	primer	primer	NN	NN	_	5	compound	_	_
4	extension	extension	NN	NN	_	5	compound	_	_
5	method	method	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	detect	detect	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CAG	cag	NN	NN	_	12	compound	_	_
12	repeats	repeat	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	androgen	androgen	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	families	family	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	26	case	_	_
21	X-linked	x-linked	JJ	JJ	_	26	amod	_	_
22	spinal	spinal	JJ	JJ	_	26	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	bulbar	bulbar	JJ	JJ	_	22	conj	_	_
25	muscular	muscular	JJ	JJ	_	26	amod	_	_
26	atrophy	atrophy	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	X-linked	x-linked	JJ	JJ	_	6	amod	_	_
2	spinal	spinal	JJ	JJ	_	6	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	bulbar	bulbar	JJ	JJ	_	2	conj	_	_
5	muscular	muscular	JJ	JJ	_	6	amod	_	_
6	atrophy	atrophy	NN	NN	_	21	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	SBMA	sbma	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	an	a	DT	DT	_	13	det	_	_
12	adult-onset	adult-onset	JJ	JJ	_	13	amod	_	_
13	form	form	NN	NN	_	6	appos	_	_
14	of	of	IN	IN	_	17	case	_	_
15	motor	motor	NN	NN	_	17	compound	_	_
16	neuron	neuron	NN	NN	_	17	compound	_	_
17	disease	disease	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	recently	recently	RB	RB	_	21	advmod	_	_
21	reported	report	VBN	VBN	_	0	root	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	caused	cause	VBN	VBN	_	21	xcomp	_	_
25	by	by	IN	IN	_	26	case	_	_
26	amplification	amplification	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	CAG	cag	NN	NN	_	30	compound	_	_
30	repeats	repeat	NNS	NNS	_	26	nmod	_	_
31	in	in	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	androgen	androgen	NN	NN	_	35	compound	_	_
34	receptor	receptor	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	a	a	DT	DT	_	8	det	_	_
5	simple	simple	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	rapid	rapid	JJ	JJ	_	5	conj	_	_
8	strategy	strategy	NN	NN	_	2	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	detect	detect	VB	VB	_	8	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	precise	precise	JJ	JJ	_	13	amod	_	_
13	number	number	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	CAGs	cag	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	fragment	fragment	NN	NN	_	10	nsubjpass	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CAG	cag	NN	NN	_	8	compound	_	_
8	repeats	repeat	NNS	NNS	_	5	dobj	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	amplified	amplify	VBN	VBN	_	21	advcl	_	_
11	by	by	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	polymerase	polymerase	NN	NN	_	15	compound	_	_
14	chain	chain	NN	NN	_	15	compound	_	_
15	reaction	reaction	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	a	a	DT	DT	_	19	det	_	_
18	primer	primer	NN	NN	_	19	compound	_	_
19	extension	extension	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	carried	carry	VBN	VBN	_	0	root	_	_
22	out	out	RP	RP	_	21	compound:prt	_	_
23	;	;	:	:	_	21	punct	_	_
24	the	the	DT	DT	_	25	det	_	_
25	extension	extension	NN	NN	_	38	nsubj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	end-labelled	end-labelled	JJ	JJ	_	30	amod	_	_
29	reverse	reverse	JJ	JJ	_	30	amod	_	_
30	primer	primer	NN	NN	_	25	nmod	_	_
31	adjacent	adjacent	JJ	JJ	_	30	amod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	3'	3'	JJ	JJ	_	34	amod	_	_
34	end	end	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	CAG	cag	NN	NN	_	37	compound	_	_
37	repeats	repeat	NNS	NNS	_	34	nmod	_	_
38	stops	stop	VBZ	VBZ	_	21	parataxis	_	_
39	at	at	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	first	first	JJ	JJ	_	42	amod	_	_
42	T	t	NN	NN	_	38	nmod	_	_
43	after	after	IN	IN	_	45	case	_	_
44	CAG	cag	NN	NN	_	45	compound	_	_
45	repeats	repeat	NNS	NNS	_	42	nmod	_	_
46	with	with	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	incorporation	incorporation	NN	NN	_	38	nmod	_	_
49	of	of	IN	IN	_	51	case	_	_
50	dideoxy	dideoxy	JJ	JJ	_	51	amod	_	_
51	ATP	atp	NN	NN	_	48	nmod	_	_
52	in	in	IN	IN	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	reaction	reaction	NN	NN	_	55	compound	_	_
55	mixture	mixture	NN	NN	_	48	nmod	_	_
56	.	.	.	.	_	38	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	resultant	resultant	JJ	JJ	_	4	amod	_	_
3	primer	primer	NN	NN	_	4	compound	_	_
4	products	product	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	analysed	analyse	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	denaturing	denature	VBG	VBG	_	6	advcl	_	_
9	polyacrylamide	polyacrylamide	NN	NN	_	11	compound	_	_
10	gel	gel	NN	NN	_	11	compound	_	_
11	electrophoresis	electrophoresis	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	autoradiography	autoradiography	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	method	method	NN	NN	_	6	nsubj	_	_
3	could	could	MD	MD	_	6	aux	_	_
4	be	be	VB	VB	_	6	cop	_	_
5	quite	quite	RB	RB	_	6	advmod	_	_
6	useful	useful	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	detect	detect	VB	VB	_	6	xcomp	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	12	cc:preconj	_	_
11	CAG	cag	NN	NN	_	12	compound	_	_
12	repeats	repeat	NNS	NNS	_	8	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	SBMA	sbma	NN	NN	_	12	nmod	_	_
15	but	but	CC	CC	_	12	cc	_	_
16	also	also	RB	RB	_	22	advmod	_	_
17	other	other	JJ	JJ	_	22	amod	_	_
18	polymorphic	polymorphic	JJ	JJ	_	22	amod	_	_
19	dinucleotide	dinucleotide	JJ	JJ	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	trinucleotide	trinucleotide	JJ	JJ	_	19	conj	_	_
22	repeats	repeat	NNS	NNS	_	12	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Activity	activity	NN	NN	_	18	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	kappa	kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	enhancer	enhancer	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	interleukin-2	interleukin-2	NN	NN	_	12	compound	_	_
10	receptor	receptor	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	chain	chain	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	somatic	somatic	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	hybrids	hybrid	NNS	NNS	_	1	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	accompanied	accompany	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	localization	localization	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	proteins	protein	NNS	NNS	_	6	compound	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	34	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	6	punct	_	_
8	consisting	consist	VBG	VBG	_	6	acl	_	_
9	of	of	IN	IN	_	10	case	_	_
10	subunits	subunit	NNS	NNS	_	8	nmod	_	_
11	p50	p50	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p65	p65	NN	NN	_	11	conj	_	_
14	)	)	-RRB-	-RRB-	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	subunit	subunit	NN	NN	_	6	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	p50	p50	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	by	by	IN	IN	_	26	case	_	_
26	itself	itself	PRP	PRP	_	18	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	also	also	RB	RB	_	29	advmod	_	_
29	called	call	VBN	VBN	_	18	acl	_	_
30	KBF1	kbf1	NN	NN	_	29	xcomp	_	_
31	,	,	,	,	_	6	punct	_	_
32	are	be	VBP	VBP	_	34	aux	_	_
33	constitutively	constitutively	RB	RB	_	34	advmod	_	_
34	expressed	express	VBN	VBN	_	0	root	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	localized	localized	JJ	JJ	_	34	conj	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	nucleus	nucleus	NN	NN	_	34	nmod	_	_
40	of	of	IN	IN	_	45	case	_	_
41	the	the	DT	DT	_	45	det	_	_
42	human	human	JJ	JJ	_	45	amod	_	_
43	T-cell	t-cell	NN	NN	_	45	compound	_	_
44	line	line	NN	NN	_	45	compound	_	_
45	IARC	iarc	NN	NN	_	39	nmod	_	_
46	301.5	301.5	CD	CD	_	45	nummod	_	_
47	.	.	.	.	_	34	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	define	define	VB	VB	_	26	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	roles	role	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	these	these	DT	DT	_	10	det	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	factors	factor	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	bind	bind	VBP	VBP	_	10	acl:relcl	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	same	same	JJ	JJ	_	19	amod	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	enhancers	enhancer	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	26	punct	_	_
21	in	in	IN	IN	_	23	case	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	26	nmod	_	_
24	we	we	PRP	PRP	_	26	nsubj	_	_
25	have	have	VBP	VBP	_	26	aux	_	_
26	prepared	prepare	VBN	VBN	_	0	root	_	_
27	somatic	somatic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	hybrids	hybrid	NNS	NNS	_	26	dobj	_	_
30	between	between	IN	IN	_	31	case	_	_
31	IARC	iarc	NN	NN	_	29	nmod	_	_
32	301.5	301.5	CD	CD	_	31	nummod	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	a	a	DT	DT	_	36	det	_	_
35	murine	murine	JJ	JJ	_	36	amod	_	_
36	myeloma	myeloma	NN	NN	_	31	conj	_	_
37	.	.	.	.	_	26	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	hybrids	hybrid	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	KBF1	kbf1	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	nuclei	nucleus	NNS	NNS	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	but	but	CC	CC	_	3	cc	_	_
14	one	one	CD	CD	_	15	nummod	_	_
15	hybrid	hybrid	NN	NN	_	16	nsubj	_	_
16	expresses	express	VBZ	VBZ	_	3	conj	_	_
17	only	only	RB	RB	_	18	advmod	_	_
18	KBF1	kbf1	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	enhancer	enhancer	NN	NN	_	22	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	gene	gene	NN	NN	_	4	nmod	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	16	det	_	_
10	interleukin-2	interleukin-2	NN	NN	_	16	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-2	il-2	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	chain	chain	NN	NN	_	8	dobj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	IL-2R	il-2r	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	functional	functional	JJ	JJ	_	0	root	_	_
23	only	only	RB	RB	_	26	advmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	hybrids	hybrid	NNS	NNS	_	22	nmod	_	_
27	expressing	express	VBG	VBG	_	26	acl	_	_
28	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	activate	activate	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	15	det	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	11	dobj	_	_
16	,	,	,	,	_	9	punct	_	_
17	while	while	IN	IN	_	23	mark	_	_
18	KBF1	kbf1	NN	NN	_	23	nsubj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	itself	itself	PRP	PRP	_	18	nmod	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	sufficient	sufficient	JJ	JJ	_	9	advcl	_	_
24	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	KBF1	kbf1	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	competitive	competitive	JJ	JJ	_	8	amod	_	_
8	inhibitor	inhibitor	NN	NN	_	2	ccomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	discuss	discuss	VB	VB	_	2	conj	_	_
14	how	how	WRB	WRB	_	19	advmod	_	_
15	these	these	DT	DT	_	16	det	_	_
16	factors	factor	NNS	NNS	_	19	nsubjpass	_	_
17	may	may	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	involved	involve	VBN	VBN	_	13	ccomp	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transient	transient	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	IL-2	il-2	NN	NN	_	29	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IL-2R	il-2r	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	25	conj	_	_
29	genes	gene	NNS	NNS	_	23	nmod	_	_
30	during	during	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	response	response	NN	NN	_	23	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Influence	influence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	estradiol	estradiol	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tamoxifen	tamoxifen	NN	NN	_	3	conj	_	_
6	on	on	IN	IN	_	7	case	_	_
7	susceptibility	susceptibility	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	breast	breast	NN	NN	_	13	compound	_	_
11	cancer	cancer	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	7	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	lysis	lysis	NN	NN	_	7	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	lymphokine-activated	lymphokine-activated	JJ	JJ	_	19	amod	_	_
18	killer	killer	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	design	design	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	combination	combination	NN	NN	_	8	compound	_	_
5	hormonal	hormonal	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	immunotherapeutic	immunotherapeutic	JJ	JJ	_	5	conj	_	_
8	protocols	protocol	NNS	NNS	_	2	nmod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	breast	breast	NN	NN	_	12	compound	_	_
11	cancer	cancer	NN	NN	_	12	compound	_	_
12	patients	patient	NNS	NNS	_	8	nmod	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	facilitated	facilitate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	analysis	analysis	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	preclinical	preclinical	JJ	JJ	_	23	amod	_	_
20	in	in	FW	FW	_	23	amod	_	_
21	vitro	vitro	FW	FW	_	20	dep	_	_
22	model	model	JJ	JJ	_	23	amod	_	_
23	systems	system	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Estrogen	estrogen	NN	NN	_	20	compound	_	_
2	receptor	receptor	NN	NN	_	20	compound	_	_
3	positive	positive	JJ	JJ	_	20	amod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	ER+	er+	JJ	JJ	_	7	dep	_	_
6	:	:	:	:	_	7	punct	_	_
7	MCF-7	mcf-7	NN	NN	_	3	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	negative	negative	JJ	JJ	_	3	conj	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	ER-	er-	JJ	JJ	_	14	dep	_	_
13	:	:	:	:	_	14	punct	_	_
14	MDA-MB-231	mda-mb-231	NN	NN	_	10	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	breast	breast	NN	NN	_	20	compound	_	_
18	cancer	cancer	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	utilized	utilize	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	evaluate	evaluate	VB	VB	_	22	xcomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	effects	effect	NNS	NNS	_	24	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	tamoxifen	tamoxifen	NN	NN	_	26	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TAM	tam	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	estradiol	estradiol	NN	NN	_	28	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	E2	e2	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	on	on	IN	IN	_	38	case	_	_
38	modulation	modulation	NN	NN	_	26	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	breast	breast	NN	NN	_	43	compound	_	_
41	cancer	cancer	NN	NN	_	43	compound	_	_
42	target	target	NN	NN	_	43	compound	_	_
43	susceptibility	susceptibility	NN	NN	_	38	nmod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	lysis	lysis	NN	NN	_	43	nmod	_	_
46	by	by	IN	IN	_	52	case	_	_
47	lymphokine-activated	lymphokine-activated	JJ	JJ	_	48	amod	_	_
48	killer	killer	NN	NN	_	52	compound	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	LAK	lak	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	cells	cell	NNS	NNS	_	45	nmod	_	_
53	.	.	.	.	_	22	punct	_	_

1	E2-stimulated	e2-stimulated	JJ	JJ	_	3	amod	_	_
2	ER+	er+	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	6	nsubj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	susceptible	susceptible	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	lysis	lysis	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	LAK	lak	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	than	than	IN	IN	_	17	case	_	_
13	corresponding	correspond	VBG	VBG	_	17	amod	_	_
14	TAM-treated	tam-treated	JJ	JJ	_	17	amod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	control	control	NN	NN	_	14	conj	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	while	while	IN	IN	_	32	mark	_	_
20	treatment	treatment	NN	NN	_	32	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	ER-	er-	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	E2	e2	NN	NN	_	20	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	TAM	tam	NN	NN	_	26	conj	_	_
29	alone	alone	RB	RB	_	26	advmod	_	_
30	did	do	VBD	VBD	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	alter	alter	VB	VB	_	6	advcl	_	_
33	from	from	IN	IN	_	34	case	_	_
34	control	control	NN	NN	_	32	nmod	_	_
35	their	they	PRP$	PRP$	_	36	nmod:poss	_	_
36	susceptibility	susceptibility	NN	NN	_	32	dobj	_	_
37	to	to	TO	TO	_	40	case	_	_
38	this	this	DT	DT	_	40	det	_	_
39	immune-mediated	immune-mediated	JJ	JJ	_	40	amod	_	_
40	lysis	lysis	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	All	all	DT	DT	_	5	det	_	_
2	ER+	er+	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	ER-	er-	JJ	JJ	_	2	conj	_	_
5	cells	cell	NNS	NNS	_	7	nsubj	_	_
6	tested	test	VBN	VBN	_	5	acl	_	_
7	remained	remain	VBD	VBD	_	0	root	_	_
8	sensitive	sensitive	JJ	JJ	_	7	xcomp	_	_
9	after	after	IN	IN	_	10	case	_	_
10	treatment	treatment	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	TAM	tam	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	lysis	lysis	NN	NN	_	7	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	LAK	lak	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	an	a	DT	DT	_	10	det	_	_
5	adenocarcinoma	adenocarcinoma	NN	NN	_	6	nmod:npmod	_	_
6	reactive	reactive	JJ	JJ	_	10	amod	_	_
7	human-mouse	human-mouse	JJ	JJ	_	8	amod	_	_
8	chimeric	chimeric	JJ	JJ	_	10	amod	_	_
9	monoclonal	monoclonal	JJ	JJ	_	10	amod	_	_
10	antibody	antibody	NN	NN	_	15	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	ING-1	ing-1	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	able	able	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	boost	boost	VB	VB	_	15	xcomp	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vivo	vivo	FW	FW	_	21	advmod	_	_
21	generated	generate	VBN	VBN	_	24	amod	_	_
22	LAK	lak	NN	NN	_	23	nmod:npmod	_	_
23	cell-mediated	cell-mediated	JJ	JJ	_	24	amod	_	_
24	lysis	lysis	NN	NN	_	18	dobj	_	_
25	of	of	IN	IN	_	35	case	_	_
26	control	control	NN	NN	_	35	compound	_	_
27	,	,	,	,	_	26	punct	_	_
28	E2-treated	e2-treated	JJ	JJ	_	26	amod	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	TAM-treated	tam-treated	JJ	JJ	_	26	conj	_	_
32	ER+	er+	JJ	JJ	_	35	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	ER-	er-	JJ	JJ	_	32	conj	_	_
35	cells	cell	NNS	NNS	_	24	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	preclinical	preclinical	JJ	JJ	_	8	amod	_	_
8	rationale	rationale	NN	NN	_	5	dobj	_	_
9	for	for	IN	IN	_	12	case	_	_
10	in	in	FW	FW	_	12	amod	_	_
11	vivo	vivo	FW	FW	_	10	dep	_	_
12	testing	testing	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	TAM	tam	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	interleukin-2	interleukin-2	NN	NN	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL-2	il-2	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	14	punct	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	breast	breast	NN	NN	_	27	compound	_	_
23	cancer	cancer	NN	NN	_	27	compound	_	_
24	reactive	reactive	JJ	JJ	_	27	amod	_	_
25	antibody-dependent	antibody-dependent	JJ	JJ	_	27	amod	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	cytotoxicity	cytotoxicity	NN	NN	_	14	conj	_	_
28	facilitating	facilitate	VBG	VBG	_	14	acl	_	_
29	antibody	antibody	NN	NN	_	28	dobj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	28	nmod	_	_
32	with	with	IN	IN	_	38	case	_	_
33	refractory	refractory	JJ	JJ	_	38	amod	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	high	high	JJ	JJ	_	36	amod	_	_
36	risk	risk	NN	NN	_	33	conj	_	_
37	breast	breast	NN	NN	_	38	compound	_	_
38	cancer	cancer	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	inhibition	inhibition	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	3-O-methyl-D-glucose	3-o-methyl-d-glucose	NN	NN	_	7	compound	_	_
7	uptake	uptake	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	humans	human	NNS	NNS	_	13	nmod	_	_
17	:	:	:	:	_	2	punct	_	_
18	correlation	correlation	NN	NN	_	2	dep	_	_
19	between	between	IN	IN	_	21	case	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	level	level	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	hormone	hormone	NN	NN	_	24	compound	_	_
24	effect	effect	NN	NN	_	21	conj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vitro	vitro	FW	FW	_	21	advmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	measured	measure	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	concentration	concentration	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	polymorphonuclear	polymorphonuclear	JJ	JJ	_	9	conj	_	_
12	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	both	both	DT	DT	_	18	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	14	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	isolated	isolate	VBN	VBN	_	12	acl:relcl	_	_
19	from	from	IN	IN	_	21	case	_	_
20	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
21	blood	blood	NN	NN	_	18	nmod	_	_
22	from	from	IN	IN	_	26	case	_	_
23	ten	ten	CD	CD	_	26	nummod	_	_
24	healthy	healthy	JJ	JJ	_	26	amod	_	_
25	male	male	JJ	JJ	_	26	amod	_	_
26	volunteers	volunteer	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	inhibitory	inhibitory	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	dexamethasone	dexamethasone	NN	NN	_	6	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	3-O-methyl-D-glucose	3-o-methyl-d-glucose	NN	NN	_	11	compound	_	_
11	uptake	uptake	NN	NN	_	6	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	assayed	assay	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	corresponding	corresponding	JJ	JJ	_	18	amod	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	leukocytes	leukocyte	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
8	correlated	correlate	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	those	those	DT	DT	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	polymorphonuclear	polymorphonuclear	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	there	there	EX	EX	_	17	expl	_	_
17	was	be	VBD	VBD	_	8	conj	_	_
18	a	a	DT	DT	_	20	det	_	_
19	linear	linear	JJ	JJ	_	20	amod	_	_
20	relationship	relationship	NN	NN	_	17	nsubj	_	_
21	between	between	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	cellular	cellular	JJ	JJ	_	26	amod	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	26	compound	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	levels	level	NNS	NNS	_	17	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	29	amod	_	_
29	inhibition	inhibition	NN	NN	_	26	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	uptake	uptake	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	3-O-methyl-D-glucose	3-o-methyl-d-glucose	NN	NN	_	32	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	mononuclear	mononuclear	JJ	JJ	_	37	amod	_	_
37	leukocytes	leukocyte	NNS	NNS	_	26	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	mononuclear	mononuclear	JJ	JJ	_	3	amod	_	_
3	leukocytes	leukocyte	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	incubated	incubate	VBN	VBN	_	16	advcl	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	dep	_	_
8	presence	presence	NN	NN	_	10	dep	_	_
9	of	of	IN	IN	_	10	case	_	_
10	8-bromo-cAMP	8-bromo-camp	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	16	punct	_	_
12	cellular	cellular	JJ	JJ	_	15	amod	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	16	nsubj	_	_
16	increased	increase	VBD	VBD	_	0	root	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	a	a	DT	DT	_	22	det	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	pronounced	pronounced	JJ	JJ	_	22	amod	_	_
21	inhibitory	inhibitory	JJ	JJ	_	22	amod	_	_
22	effect	effect	NN	NN	_	26	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	dexamethasone	dexamethasone	NN	NN	_	22	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	observed	observe	VBN	VBN	_	16	conj	_	_
27	on	on	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	transport	transport	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	3-O-methyl-D-glucose	3-o-methyl-d-glucose	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	cellular	cellular	JJ	JJ	_	8	amod	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	13	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	reflect	reflect	VBP	VBP	_	2	ccomp	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	responsiveness	responsiveness	NN	NN	_	13	dobj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	glucocorticoids	glucocorticoid	NNS	NNS	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	mononuclear	mononuclear	JJ	JJ	_	21	amod	_	_
21	leukocytes	leukocyte	NNS	NNS	_	18	nmod	_	_
22	from	from	IN	IN	_	24	case	_	_
23	healthy	healthy	JJ	JJ	_	24	amod	_	_
24	males	male	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	13	punct	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	individual	individual	JJ	JJ	_	30	amod	_	_
30	responsiveness	responsiveness	NN	NN	_	32	nsubj	_	_
31	may	may	MD	MD	_	32	aux	_	_
32	alter	alter	VB	VB	_	13	conj	_	_
33	upon	upon	IN	IN	_	34	case	_	_
34	changes	change	NNS	NNS	_	32	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	cellular	cellular	JJ	JJ	_	38	amod	_	_
38	levels	level	NNS	NNS	_	34	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	glucocorticoid	glucocorticoid	NN	NN	_	41	compound	_	_
41	receptor	receptor	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	interferon	interferon	NN	NN	_	6	compound	_	_
4	beta	beta	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	1	nmod	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	6	advmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	purified	purify	VBN	VBN	_	12	amod	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	17	det	_	_
15	novel	novel	JJ	JJ	_	17	amod	_	_
16	TH	th	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	human	human	JJ	JJ	_	9	amod	_	_
3	interferon	interferon	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IFN-beta	ifn-beta	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	10	nsubj	_	_
10	consists	consist	VBZ	VBZ	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	multiple	multiple	JJ	JJ	_	14	amod	_	_
13	enhanson	enhanson	NN	NN	_	14	compound	_	_
14	domains	domain	NNS	NNS	_	10	nmod	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	targets	target	NNS	NNS	_	14	acl:relcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	17	nmod	_	_
21	involved	involve	VBN	VBN	_	20	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	inducible	inducible	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	promoter	promoter	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	characterize	characterize	VB	VB	_	21	advcl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	protein-DNA	protein-dna	JJ	JJ	_	6	amod	_	_
6	interactions	interaction	NNS	NNS	_	3	dobj	_	_
7	mediating	mediate	VBG	VBG	_	6	acl	_	_
8	IFN-beta	ifn-beta	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	21	punct	_	_
11	positive	positive	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	domain	domain	NN	NN	_	19	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PRD	prd	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	II	ii	CD	CD	_	19	nummod	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	21	nsubjpass	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	purified	purify	VBN	VBN	_	0	root	_	_
22	from	from	IN	IN	_	27	case	_	_
23	phorbol	phorbol	NN	NN	_	24	compound	_	_
24	ester	ester	NN	NN	_	25	nmod:npmod	_	_
25	induced	induced	JJ	JJ	_	27	amod	_	_
26	Jurkat	jurkat	NN	NN	_	27	compound	_	_
27	T-cells	t-cell	NNS	NNS	_	21	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	from	from	IN	IN	_	31	case	_	_
30	IFN	ifn	NN	NN	_	31	dep	_	_
31	primed	prime	VBN	VBN	_	27	conj	_	_
32	,	,	,	,	_	31	punct	_	_
33	cycloheximide/polyinosinic-polycytidylic	cycloheximide/polyinosinic-polycytidylic	JJ	JJ	_	34	amod	_	_
34	acid	acid	NN	NN	_	35	dep	_	_
35	treated	treat	VBN	VBN	_	31	dep	_	_
36	HeLa	hela	NN	NN	_	31	dep	_	_
37	S3	s3	NN	NN	_	31	dep	_	_
38	cells	cell	NNS	NNS	_	31	dep	_	_
39	.	.	.	.	_	21	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	HeLa	hela	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	major	major	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	16	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	52	52	CD	CD	_	12	nummod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	45	45	CD	CD	_	9	conj	_	_
12	kilodaltons	kilodalton	NNS	NNS	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	kD	kd	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	copurified	copurify	VBD	VBD	_	0	root	_	_
17	with	with	IN	IN	_	20	case	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	whereas	whereas	IN	IN	_	16	dep	_	_
23	from	from	IN	IN	_	24	case	_	_
24	T-cells	t-cell	NNS	NNS	_	49	nmod	_	_
25	,	,	,	,	_	49	punct	_	_
26	four	four	CD	CD	_	27	nummod	_	_
27	proteins	protein	NNS	NNS	_	49	nsubjpass	_	_
28	--	--	:	:	_	27	punct	_	_
29	a	a	DT	DT	_	31	det	_	_
30	major	major	JJ	JJ	_	31	amod	_	_
31	protein	protein	NN	NN	_	27	dep	_	_
32	of	of	IN	IN	_	34	case	_	_
33	52	52	CD	CD	_	34	nummod	_	_
34	kD	kd	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	three	three	CD	CD	_	38	nummod	_	_
37	minor	minor	JJ	JJ	_	38	amod	_	_
38	proteins	protein	NNS	NNS	_	31	conj	_	_
39	of	of	IN	IN	_	46	case	_	_
40	82	82	CD	CD	_	42	nummod	_	_
41	,	,	,	,	_	42	punct	_	_
42	67	67	CD	CD	_	46	nummod	_	_
43	,	,	,	,	_	42	punct	_	_
44	and	and	CC	CC	_	42	cc	_	_
45	43-47	43-47	CD	CD	_	42	conj	_	_
46	kD	kd	NN	NN	_	38	nmod	_	_
47	--	--	:	:	_	27	punct	_	_
48	were	be	VBD	VBD	_	49	auxpass	_	_
49	purified	purify	VBN	VBN	_	16	parataxis	_	_
50	.	.	.	.	_	16	punct	_	_

1	Also	also	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	an	a	DT	DT	_	8	det	_	_
4	induction	induction	NN	NN	_	5	nmod:npmod	_	_
5	specific	specific	JJ	JJ	_	8	amod	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	purified	purify	VBN	VBN	_	0	root	_	_
11	from	from	IN	IN	_	13	case	_	_
12	HeLa	hela	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	interacted	interact	VBD	VBD	_	13	acl:relcl	_	_
16	with	with	IN	IN	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	(	(	-LRB-	-LRB-	_	23	punct	_	_
19	AAGTGA	aagtga	NN	NN	_	23	compound	_	_
20	)	)	-RRB-	-RRB-	_	23	punct	_	_
21	4	4	CD	CD	_	23	nummod	_	_
22	tetrahexamer	tetrahexamer	NN	NN	_	23	compound	_	_
23	sequence	sequence	NN	NN	_	15	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	27	det	_	_
26	PRDI	prdi	NN	NN	_	27	compound	_	_
27	domain	domain	NN	NN	_	23	conj	_	_
28	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	immunologically	immunologically	RB	RB	_	5	advmod	_	_
5	distinct	distinct	JJ	JJ	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	IRF-1/ISGF2	irf-1/isgf2	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Uninduced	uninduced	JJ	JJ	_	7	amod	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	Sendai	sendai	NN	NN	_	4	compound	_	_
4	virus	virus	NN	NN	_	5	nmod:npmod	_	_
5	induced	induced	JJ	JJ	_	1	conj	_	_
6	HeLa	hela	NN	NN	_	7	compound	_	_
7	extracts	extract	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	examine	examine	VB	VB	_	9	xcomp	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	11	advmod	_	_
15	using	use	VBG	VBG	_	11	xcomp	_	_
16	a	a	DT	DT	_	17	det	_	_
17	series	series	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	IFN	ifn	NN	NN	_	22	compound	_	_
20	beta	beta	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	deletions	deletion	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Deletions	deletion	NNS	NNS	_	7	nsubj	_	_
2	upstream	upstream	JJ	JJ	_	1	amod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	PRDII	prdii	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	2	nmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	uninduced	uninduced	JJ	JJ	_	12	amod	_	_
12	extract	extract	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	indicating	indicate	VBG	VBG	_	7	advcl	_	_
15	predominantly	predominantly	RB	RB	_	16	advmod	_	_
16	negative	negative	JJ	JJ	_	17	amod	_	_
17	regulation	regulation	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	promoter	promoter	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	2-4-fold	2-4-fold	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	9	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	IFN-beta	ifn-beta	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	transcription	transcription	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	14	case	_	_
11	Sendai	sendai	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	13	nmod:npmod	_	_
13	induced	induced	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	deletion	deletion	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	PRDI	prdi	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	PRDII	prdii	NN	NN	_	19	conj	_	_
22	elements	element	NNS	NNS	_	17	nmod	_	_
23	decreased	decrease	VBD	VBD	_	9	conj	_	_
24	this	this	DT	DT	_	26	det	_	_
25	induced	induce	VBN	VBN	_	26	amod	_	_
26	level	level	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	transcription	transcription	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	When	when	WRB	WRB	_	9	advmod	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	PRDII	prdii	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tetrahexamer	tetrahexamer	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	3	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	added	add	VBN	VBN	_	21	advcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	induced	induce	VBN	VBN	_	13	amod	_	_
13	extract	extract	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	21	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	4-fold	4-fold	JJ	JJ	_	17	amod	_	_
17	increase	increase	NN	NN	_	21	nsubjpass	_	_
18	in	in	IN	IN	_	19	case	_	_
19	transcription	transcription	NN	NN	_	17	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	observed	observe	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	it	it	PRP	PRP	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	possible	possible	JJ	JJ	_	3	ccomp	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	modulate	modulate	VB	VB	_	7	xcomp	_	_
10	IFN-beta	ifn-beta	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	9	advmod	_	_
14	but	but	CC	CC	_	3	cc	_	_
15	indicate	indicate	VBP	VBP	_	3	conj	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	additional	additional	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	21	nsubjpass	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	15	ccomp	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	fully	fully	RB	RB	_	24	advmod	_	_
24	activate	activate	VB	VB	_	21	xcomp	_	_
25	IFN-beta	ifn-beta	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Structure	structure	NN	NN	_	3	compound	_	_
2	function	function	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	vitamin	vitamin	NN	NN	_	7	compound	_	_
6	D	d	NN	NN	_	7	compound	_	_
7	analogs	analog	NNS	NNS	_	3	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	C-ring	c-ring	NN	NN	_	10	compound	_	_
10	modifications	modification	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Analogs	analog	NNS	NNS	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	1	1	CD	CD	_	5	nummod	_	_
4	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	with	with	IN	IN	_	11	case	_	_
11	substitutions	substitution	NNS	NNS	_	1	nmod	_	_
12	on	on	IN	IN	_	13	case	_	_
13	C-11	c-11	NN	NN	_	11	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	synthesized	synthesize	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Small	small	JJ	JJ	_	3	amod	_	_
2	apolar	apolar	JJ	JJ	_	3	amod	_	_
3	substitutions	substitution	NNS	NNS	_	14	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	11	11	CD	CD	_	6	nummod	_	_
6	alpha-methyl	alpha-methyl	NN	NN	_	3	dep	_	_
7	,	,	,	,	_	6	punct	_	_
8	11	11	CD	CD	_	9	nummod	_	_
9	alpha-fluoromethyl	alpha-fluoromethyl	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	6	punct	_	_
11	did	do	VBD	VBD	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	markedly	markedly	RB	RB	_	14	advmod	_	_
14	decrease	decrease	VB	VB	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	affinity	affinity	NN	NN	_	14	dobj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	vitamin	vitamin	NN	NN	_	21	compound	_	_
20	D	d	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	14	punct	_	_
23	but	but	CC	CC	_	14	cc	_	_
24	larger	larger	JJR	JJR	_	38	amod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	11	11	CD	CD	_	27	nummod	_	_
27	alpha-chloromethyl	alpha-chloromethyl	NN	NN	_	24	dep	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	11	11	CD	CD	_	30	nummod	_	_
30	alpha-	alpha-	NN	NN	_	27	conj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	11	11	CD	CD	_	33	nummod	_	_
33	beta-phenyl	beta-phenyl	NN	NN	_	30	conj	_	_
34	)	)	-RRB-	-RRB-	_	27	punct	_	_
35	or	or	CC	CC	_	24	cc	_	_
36	more	more	RBR	RBR	_	37	advmod	_	_
37	polar	polar	JJ	JJ	_	24	conj	_	_
38	substitutions	substitution	NNS	NNS	_	46	nsubj	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	11	11	CD	CD	_	41	nummod	_	_
41	alpha-hydroxymethyl	alpha-hydroxymethyl	NN	NN	_	38	dep	_	_
42	,	,	,	,	_	41	punct	_	_
43	11	11	CD	CD	_	44	nummod	_	_
44	alpha-(2-hydroxyethyl	alpha-(2-hydroxyethyl	NN	NN	_	41	appos	_	_
45	-RSB-	-rsb-	-RRB-	-RRB-	_	41	punct	_	_
46	decreased	decrease	VBD	VBD	_	14	conj	_	_
47	the	the	DT	DT	_	48	det	_	_
48	affinity	affinity	NN	NN	_	46	dobj	_	_
49	to	to	TO	TO	_	53	case	_	_
50	less	less	JJR	JJR	_	52	advmod	_	_
51	than	than	IN	IN	_	50	mwe	_	_
52	5	5	CD	CD	_	53	nummod	_	_
53	%	%	NN	NN	_	46	nmod	_	_
54	of	of	IN	IN	_	55	case	_	_
55	that	that	DT	DT	_	53	nmod	_	_
56	of	of	IN	IN	_	58	case	_	_
57	1	1	CD	CD	_	58	nummod	_	_
58	alpha,25-OH)2D3	alpha,25-oh)2d3	NN	NN	_	55	nmod	_	_
59	.	.	.	.	_	14	punct	_	_

1	Their	they	PRP$	PRP$	_	2	nmod:poss	_	_
2	affinity	affinity	NN	NN	_	11	nsubj	_	_
3	for	for	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	vitamin	vitamin	NN	NN	_	6	nmod:npmod	_	_
6	D-binding	d-binding	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	however	however	RB	RB	_	11	advmod	_	_
10	,	,	,	,	_	11	punct	_	_
11	increased	increase	VBD	VBD	_	0	root	_	_
12	up	up	RB	RB	_	14	advmod	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	4-fold	4-fold	RB	RB	_	11	advmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biological	biological	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	11	11	CD	CD	_	7	nummod	_	_
6	alpha-methyl-1	alpha-methyl-1	NN	NN	_	7	compound	_	_
7	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	3	nmod	_	_
8	closely	closely	RB	RB	_	9	advmod	_	_
9	resembled	resemble	VBD	VBD	_	0	root	_	_
10	that	that	DT	DT	_	9	xcomp	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	natural	natural	JJ	JJ	_	14	amod	_	_
14	hormone	hormone	NN	NN	_	10	nmod	_	_
15	on	on	IN	IN	_	20	case	_	_
16	normal	normal	JJ	JJ	_	20	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	leukemic	leukemic	JJ	JJ	_	16	conj	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	proliferation	proliferation	NN	NN	_	10	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	bone	bone	NN	NN	_	23	compound	_	_
23	resorption	resorption	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	9	punct	_	_
25	whereas	whereas	IN	IN	_	9	dep	_	_
26	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
27	in	in	FW	FW	_	29	amod	_	_
28	vivo	vivo	FW	FW	_	27	dep	_	_
29	effect	effect	NN	NN	_	40	nsubj	_	_
30	on	on	IN	IN	_	32	case	_	_
31	calcium	calcium	NN	NN	_	32	compound	_	_
32	metabolism	metabolism	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	rachitic	rachitic	JJ	JJ	_	36	amod	_	_
36	chick	chick	NN	NN	_	32	nmod	_	_
37	was	be	VBD	VBD	_	40	cop	_	_
38	about	about	IN	IN	_	39	advmod	_	_
39	50	50	CD	CD	_	40	nummod	_	_
40	%	%	NN	NN	_	9	parataxis	_	_
41	of	of	IN	IN	_	42	case	_	_
42	that	that	DT	DT	_	40	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	1	1	CD	CD	_	45	nummod	_	_
45	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	11	11	CD	CD	_	4	nummod	_	_
3	beta-methyl	beta-methyl	NN	NN	_	4	compound	_	_
4	analog	analog	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	11	det	_	_
7	greater	greater	JJR	JJR	_	9	dep	_	_
8	than	than	IN	IN	_	9	case	_	_
9	10-fold	10-fold	RB	RB	_	10	advmod	_	_
10	lower	lower	JJR	JJR	_	11	amod	_	_
11	activity	activity	NN	NN	_	5	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	differentiating	differentiating	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	17	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	C-11	c-11	NN	NN	_	8	compound	_	_
8	analogs	analog	NNS	NNS	_	3	nmod	_	_
9	on	on	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	promyeloid	promyeloid	JJ	JJ	_	13	amod	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HL-60	hl-60	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	agreed	agree	VBD	VBD	_	0	root	_	_
18	well	well	RB	RB	_	17	advmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	bone-resorbing	bone-resorbing	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	affinity	affinity	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	17	punct	_	_
27	but	but	CC	CC	_	17	cc	_	_
28	they	they	PRP	PRP	_	29	nsubj	_	_
29	demonstrated	demonstrate	VBD	VBD	_	17	conj	_	_
30	lower	lower	JJR	JJR	_	32	amod	_	_
31	calcemic	calcemic	JJ	JJ	_	32	amod	_	_
32	effects	effect	NNS	NNS	_	29	dobj	_	_
33	in	in	FW	FW	_	34	compound	_	_
34	vivo	vivo	FW	FW	_	29	advmod	_	_
35	.	.	.	.	_	17	punct	_	_

1	Large	large	JJ	JJ	_	4	amod	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	polar	polar	JJ	JJ	_	1	conj	_	_
4	substitutions	substitution	NNS	NNS	_	11	nsubj	_	_
5	on	on	IN	IN	_	6	case	_	_
6	C-11	c-11	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	6	nmod	_	_
10	thus	thus	RB	RB	_	11	advmod	_	_
11	impair	impair	VBP	VBP	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	binding	binding	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	vitamin	vitamin	NN	NN	_	18	compound	_	_
17	D	d	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	13	nmod	_	_
19	but	but	CC	CC	_	11	cc	_	_
20	increase	increase	VBP	VBP	_	11	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	affinity	affinity	NN	NN	_	20	dobj	_	_
23	to	to	TO	TO	_	26	case	_	_
24	vitamin	vitamin	NN	NN	_	25	nmod:npmod	_	_
25	D-binding	d-binding	JJ	JJ	_	26	amod	_	_
26	protein	protein	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	many	many	JJ	JJ	_	8	amod	_	_
5	C-11-substituted	c-11-substituted	JJ	JJ	_	8	amod	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	8	compound	_	_
8	analogs	analog	NNS	NNS	_	2	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	HL-60	hl-60	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	differentiation	differentiation	NN	NN	_	2	nmod	_	_
13	exceeded	exceed	VBD	VBD	_	0	root	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	calcium	calcium	NN	NN	_	18	compound	_	_
18	metabolism	metabolism	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	during	during	IN	IN	_	5	case	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	development	development	NN	NN	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	alpha	alpha	NN	NN	_	10	compound	_	_
9	TCR	tcr	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	2	dep	_	_
11	as	as	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	model	model	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	complex	complex	JJ	JJ	_	12	amod	_	_
12	process	process	NN	NN	_	0	root	_	_
13	involving	involve	VBG	VBG	_	12	acl	_	_
14	interactions	interaction	NNS	NNS	_	13	dobj	_	_
15	between	between	IN	IN	_	22	case	_	_
16	multiple	multiple	JJ	JJ	_	22	amod	_	_
17	positive	positive	JJ	JJ	_	22	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	negative	negative	JJ	JJ	_	17	conj	_	_
20	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	14	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	article	article	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	regulation	regulation	NN	NN	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	archetypal	archetypal	JJ	JJ	_	11	amod	_	_
10	T-cell-specific	t-cell-specific	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	alpha	alpha	NN	NN	_	14	compound	_	_
14	TCR	tcr	NN	NN	_	11	appos	_	_
15	,	,	,	,	_	11	punct	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	discussed	discuss	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Major	major	JJ	JJ	_	3	amod	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	developments	development	NNS	NNS	_	27	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	including	include	VBG	VBG	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	identification	identification	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	families	family	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	regulate	regulate	VBP	VBP	_	13	acl:relcl	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	15	dobj	_	_
19	during	during	IN	IN	_	21	case	_	_
20	thymocyte	thymocyte	NN	NN	_	21	compound	_	_
21	ontogeny	ontogeny	NN	NN	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	3	punct	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	described	describe	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	Cortisol	cortisol	NN	NN	_	2	compound	_	_
2	resistance	resistance	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	acquired	acquire	VBN	VBN	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	syndrome	syndrome	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	concerns	concern	VBZ	VBZ	_	0	root	_	_
4	9	9	CD	CD	_	7	nummod	_	_
5	iv	iv	NN	NN	_	7	compound	_	_
6	drug	drug	NN	NN	_	7	compound	_	_
7	abusers	abuser	NNS	NNS	_	3	dobj	_	_
8	with	with	IN	IN	_	11	case	_	_
9	acquired	acquire	VBN	VBN	_	11	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
11	syndrome	syndrome	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AIDS	aids	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	who	who	WP	WP	_	16	nsubj	_	_
16	developed	develop	VBD	VBD	_	3	dep	_	_
17	hypercortisolism	hypercortisolism	NN	NN	_	16	dobj	_	_
18	without	without	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	clinical	clinical	JJ	JJ	_	21	amod	_	_
21	signs	sign	NNS	NNS	_	16	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	metabolic	metabolic	JJ	JJ	_	24	amod	_	_
24	consequences	consequence	NNS	NNS	_	21	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	hypercortisolism	hypercortisolism	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	Addisonian	addisonian	JJ	JJ	_	8	amod	_	_
8	picture	picture	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	weakness	weakness	NN	NN	_	8	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	weight	weight	NN	NN	_	13	compound	_	_
13	loss	loss	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	hypotension	hypotension	NN	NN	_	10	conj	_	_
16	,	,	,	,	_	10	punct	_	_
17	hyponatremia	hyponatremia	NN	NN	_	10	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	intense	intense	JJ	JJ	_	22	amod	_	_
21	mucocutaneous	mucocutaneous	JJ	JJ	_	22	amod	_	_
22	melanosis	melanosis	NN	NN	_	10	conj	_	_
23	)	)	-RRB-	-RRB-	_	10	punct	_	_
24	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	acquired	acquired	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
6	resistance	resistance	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	suspected	suspect	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	5	nsubj	_	_
2	,	,	,	,	_	5	punct	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	examined	examine	VBD	VBD	_	0	root	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	characteristics	characteristic	NNS	NNS	_	5	dobj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	measuring	measure	VBG	VBG	_	5	advcl	_	_
14	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	dexamethasone	dexamethasone	NN	NN	_	18	nmod	_	_
21	on	on	IN	IN	_	23	case	_	_
22	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	23	compound	_	_
23	incorporation	incorporation	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	one	one	CD	CD	_	23	acl:relcl	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	effects	effect	NNS	NNS	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	glucocorticoid	glucocorticoid	NN	NN	_	34	compound	_	_
33	receptor	receptor	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	density	density	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	increased	increase	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	AIDS	aids	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	Addisonian	addisonian	JJ	JJ	_	12	amod	_	_
12	picture	picture	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	group	group	NN	NN	_	8	dep	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	;	;	:	:	_	14	punct	_	_
17	16.2	16.2	CD	CD	_	21	nummod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	9.4	9.4	CD	CD	_	17	conj	_	_
20	fmol/million	fmol/million	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	dep	_	_
22	)	)	-RRB-	-RRB-	_	14	punct	_	_
23	compared	compare	VBN	VBN	_	5	dep	_	_
24	to	to	TO	TO	_	25	case	_	_
25	values	value	NNS	NNS	_	23	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	12	12	CD	CD	_	29	nummod	_	_
28	AIDS	aids	NN	NN	_	29	compound	_	_
29	patients	patient	NNS	NNS	_	25	nmod	_	_
30	without	without	IN	IN	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	Addisonian	addisonian	JJ	JJ	_	33	amod	_	_
33	picture	picture	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	47	punct	_	_
35	group	group	NN	NN	_	47	dep	_	_
36	2	2	CD	CD	_	35	nummod	_	_
37	;	;	:	:	_	35	punct	_	_
38	6.05	6.05	CD	CD	_	42	nummod	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	2.6	2.6	CD	CD	_	38	conj	_	_
41	fmol/million	fmol/million	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	35	dep	_	_
43	;	;	:	:	_	47	punct	_	_
44	P	p	NN	NN	_	47	dep	_	_
45	less	less	JJR	JJR	_	47	advmod	_	_
46	than	than	IN	IN	_	45	mwe	_	_
47	0.01	0.01	CD	CD	_	29	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	and	and	CC	CC	_	29	cc	_	_
50	sex-	sex-	NN	NN	_	53	amod	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	age-matched	age-matched	JJ	JJ	_	50	conj	_	_
53	controls	control	NNS	NNS	_	29	conj	_	_
54	(	(	-LRB-	-LRB-	_	64	punct	_	_
55	3.15	3.15	CD	CD	_	59	nummod	_	_
56	+/-	+/-	CC	CC	_	55	cc	_	_
57	2.3	2.3	CD	CD	_	55	conj	_	_
58	fmol/million	fmol/million	NN	NN	_	59	compound	_	_
59	cells	cell	NNS	NNS	_	64	dep	_	_
60	;	;	:	:	_	64	punct	_	_
61	P	p	NN	NN	_	64	dep	_	_
62	less	less	JJR	JJR	_	64	advmod	_	_
63	than	than	IN	IN	_	62	mwe	_	_
64	0.01	0.01	CD	CD	_	53	dep	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	affinity	affinity	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Kd	kd	NN	NN	_	2	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	was	be	VBD	VBD	_	11	aux	_	_
10	strikingly	strikingly	RB	RB	_	11	advmod	_	_
11	decreased	decrease	VBN	VBN	_	0	root	_	_
12	(	(	-LRB-	-LRB-	_	39	punct	_	_
13	9.36	9.36	CD	CD	_	16	nummod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	3.44	3.44	CD	CD	_	13	conj	_	_
16	nM	nm	NN	NN	_	39	dep	_	_
17	in	in	IN	IN	_	18	case	_	_
18	group	group	NN	NN	_	16	nmod	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	;	;	:	:	_	16	punct	_	_
21	3.2	3.2	CD	CD	_	24	nummod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	1.5	1.5	CD	CD	_	21	conj	_	_
24	nM	nm	NN	NN	_	16	dep	_	_
25	in	in	IN	IN	_	26	case	_	_
26	group	group	NN	NN	_	24	nmod	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	;	;	:	:	_	16	punct	_	_
29	2.0	2.0	CD	CD	_	32	nummod	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	0.8	0.8	CD	CD	_	29	conj	_	_
32	nM	nm	NN	NN	_	16	dep	_	_
33	in	in	IN	IN	_	34	case	_	_
34	controls	control	NNS	NNS	_	32	nmod	_	_
35	;	;	:	:	_	39	punct	_	_
36	P	p	NN	NN	_	39	dep	_	_
37	less	less	JJR	JJR	_	39	advmod	_	_
38	than	than	IN	IN	_	37	mwe	_	_
39	0.01	0.01	CD	CD	_	11	parataxis	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	11	punct	_	_

1	-LSB-3H-RSB-Thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	2	compound	_	_
2	incorporation	incorporation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	decreased	decrease	VBN	VBN	_	0	root	_	_
5	dose-dependently	dose-dependently	RB	RB	_	4	advmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	controls	control	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	patients	patient	NNS	NNS	_	9	conj	_	_
12	;	;	:	:	_	4	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effect	effect	NN	NN	_	17	nsubj	_	_
15	was	be	VBD	VBD	_	17	aux	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	blunted	blunt	VBN	VBN	_	4	parataxis	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	P	p	NN	NN	_	22	dep	_	_
20	less	less	JJR	JJR	_	22	advmod	_	_
21	than	than	IN	IN	_	20	mwe	_	_
22	0.05	0.05	CD	CD	_	17	parataxis	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	in	in	IN	IN	_	27	case	_	_
25	group	group	NN	NN	_	27	compound	_	_
26	1	1	CD	CD	_	27	nummod	_	_
27	patients	patient	NNS	NNS	_	17	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	which	which	WDT	WDT	_	30	nsubj	_	_
30	suggests	suggest	VBZ	VBZ	_	17	ccomp	_	_
31	that	that	IN	IN	_	37	mark	_	_
32	activation	activation	NN	NN	_	37	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	glucocorticoid	glucocorticoid	NN	NN	_	35	compound	_	_
35	receptor	receptor	NN	NN	_	32	nmod	_	_
36	is	be	VBZ	VBZ	_	37	cop	_	_
37	impaired	impaired	JJ	JJ	_	30	ccomp	_	_
38	as	as	IN	IN	_	40	case	_	_
39	a	a	DT	DT	_	40	det	_	_
40	result	result	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	glucocorticoid	glucocorticoid	NN	NN	_	45	compound	_	_
44	receptor	receptor	NN	NN	_	45	compound	_	_
45	abnormality	abnormality	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	AIDS	aids	NN	NN	_	5	compound	_	_
5	patients	patient	NNS	NNS	_	17	nsubjpass	_	_
6	with	with	IN	IN	_	7	case	_	_
7	hypercortisolism	hypercortisolism	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	clinical	clinical	JJ	JJ	_	10	amod	_	_
10	features	feature	NNS	NNS	_	7	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
13	resistance	resistance	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	characterized	characterize	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	21	case	_	_
19	abnormal	abnormal	JJ	JJ	_	21	amod	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	17	nmod	_	_
22	on	on	IN	IN	_	23	case	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	Resistance	resistance	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	implies	imply	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	complex	complex	JJ	JJ	_	7	amod	_	_
7	change	change	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	immune-endocrine	immune-endocrine	JJ	JJ	_	10	amod	_	_
10	function	function	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	15	nsubj	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	important	important	JJ	JJ	_	10	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	course	course	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	21	compound	_	_
21	syndrome	syndrome	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	monocytic	monocytic	JJ	JJ	_	4	amod	_	_
4	differentiation	differentiation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	nmod:npmod	_	_
7	B-like	b-like	JJ	JJ	_	8	amod	_	_
8	activities	activity	NNS	NNS	_	4	conj	_	_
9	by	by	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	14	compound	_	_
12	virus	virus	NN	NN	_	14	compound	_	_
13	1	1	CD	CD	_	14	nummod	_	_
14	infection	infection	NN	NN	_	1	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	myelomonoblastic	myelomonoblastic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	virus	virus	NN	NN	_	11	compound	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HIV-1	hiv-1	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	infection	infection	NN	NN	_	2	nmod	_	_
12	on	on	IN	IN	_	14	case	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	2	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
17	B	b	NN	NN	_	20	compound	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	14	conj	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	investigated	investigate	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	new	new	JJ	JJ	_	27	amod	_	_
27	model	model	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	myeloid	myeloid	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	PLB-985	plb-985	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	represent	represent	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	bipotential	bipotential	JJ	JJ	_	8	amod	_	_
6	myelomonoblastic	myelomonoblastic	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	population	population	NN	NN	_	3	dobj	_	_
9	capable	capable	JJ	JJ	_	8	amod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	granulocytic	granulocytic	JJ	JJ	_	15	amod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	monocytic	monocytic	JJ	JJ	_	12	conj	_	_
15	differentiation	differentiation	NN	NN	_	9	nmod	_	_
16	after	after	IN	IN	_	17	case	_	_
17	induction	induction	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	appropriate	appropriate	JJ	JJ	_	20	amod	_	_
20	inducers	inducer	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	5	case	_	_
2	virtue	virtue	NN	NN	_	5	dep	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	17	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CD4	cd4	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	surface	surface	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	17	punct	_	_
13	PLB-985	plb-985	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
15	were	be	VBD	VBD	_	17	auxpass	_	_
16	chronically	chronically	RB	RB	_	17	advmod	_	_
17	infected	infect	VBN	VBN	_	0	root	_	_
18	with	with	IN	IN	_	21	case	_	_
19	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
20	strain	strain	NN	NN	_	21	compound	_	_
21	IIIB	iiib	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	PLB-IIIB	plb-iiib	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	clearly	clearly	RB	RB	_	4	advmod	_	_
4	possessed	possess	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	phenotype	phenotype	NN	NN	_	4	dobj	_	_
9	than	than	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	parental	parental	JJ	JJ	_	12	amod	_	_
12	myeloblasts	myeloblast	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	determined	determine	VBN	VBN	_	4	advcl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	differential	differential	JJ	JJ	_	18	amod	_	_
18	staining	staining	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	increased	increase	VBN	VBN	_	21	amod	_	_
21	expression	expression	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	myeloid-specific	myeloid-specific	JJ	JJ	_	26	amod	_	_
25	surface	surface	NN	NN	_	26	compound	_	_
26	markers	marker	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	transcription	transcription	NN	NN	_	18	conj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	c-fms	c-fms	NN	NN	_	33	compound	_	_
33	proto-oncogene	proto-oncogene	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	inducible	inducible	JJ	JJ	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	tumor	tumor	NN	NN	_	10	compound	_	_
9	necrosis	necrosis	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	phorbol	phorbol	NN	NN	_	14	compound	_	_
13	myristate	myristate	NN	NN	_	14	compound	_	_
14	acetate	acetate	NN	NN	_	10	conj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	PLB-985	plb-985	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	PLB-IIIB	plb-iiib	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	16	nmod	_	_
6	,	,	,	,	_	16	punct	_	_
7	constitutive	constitutive	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	16	nsubjpass	_	_
9	of	of	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	novel	novel	JJ	JJ	_	14	amod	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	8	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	detected	detect	VBN	VBN	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	composed	compose	VBN	VBN	_	16	dep	_	_
19	of	of	IN	IN	_	20	case	_	_
20	proteins	protein	NNS	NNS	_	18	nmod	_	_
21	ranging	range	VBG	VBG	_	20	acl	_	_
22	between	between	IN	IN	_	26	case	_	_
23	70	70	CD	CD	_	26	nummod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	110	110	CD	CD	_	23	conj	_	_
26	kD	kd	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	3	nsubj	_	_
3	interacted	interact	VBD	VBD	_	0	root	_	_
4	specifically	specifically	RB	RB	_	10	advmod	_	_
5	with	with	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	symmetric	symmetric	JJ	JJ	_	10	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	3	nmod	_	_
11	from	from	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	interferon	interferon	NN	NN	_	14	compound	_	_
14	beta	beta	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IFN-beta	ifn-beta	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	promoter	promoter	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Mutations	mutation	NNS	NNS	_	13	nsubj	_	_
2	affecting	affect	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	5'	5'	JJ	JJ	_	6	amod	_	_
5	guanine	guanine	JJ	JJ	_	6	amod	_	_
6	residues	residue	NNS	NNS	_	2	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	6	nmod	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	unable	unable	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	compete	compete	VB	VB	_	13	xcomp	_	_
16	for	for	IN	IN	_	20	case	_	_
17	these	these	DT	DT	_	20	det	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	nmod:npmod	_	_
19	B-related	b-related	JJ	JJ	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Inducibility	inducibility	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	endogenous	endogenous	JJ	JJ	_	7	amod	_	_
4	IFN-beta	ifn-beta	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	4	conj	_	_
7	RNA	rna	NN	NN	_	1	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	increased	increase	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	PLB-IIIB	plb-iiib	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	infection	infection	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	myelomonoblastic	myelomonoblastic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	select	select	VB	VB	_	3	ccomp	_	_
12	for	for	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	mature	mature	JJ	JJ	_	17	amod	_	_
16	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
17	phenotype	phenotype	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	that	that	IN	IN	_	30	mark	_	_
20	unique	unique	JJ	JJ	_	22	amod	_	_
21	subunit	subunit	NN	NN	_	22	compound	_	_
22	associations	association	NNS	NNS	_	30	nsubj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
25	B	b	NN	NN	_	28	compound	_	_
26	DNA	dna	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	22	nmod	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	contribute	contribute	VB	VB	_	11	conj	_	_
31	to	to	TO	TO	_	36	case	_	_
32	differential	differential	JJ	JJ	_	36	amod	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	nmod:npmod	_	_
34	B-mediated	b-mediated	JJ	JJ	_	36	amod	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	AP-1	ap-1	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	16	nsubj	_	_
4	at	at	IN	IN	_	6	case	_	_
5	-150	-150	CD	CD	_	6	nummod	_	_
6	bp	bp	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	3	cc	_	_
10	the	the	DT	DT	_	13	det	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	3	conj	_	_
14	,	,	,	,	_	3	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	likely	likely	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	represent	represent	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	major	major	JJ	JJ	_	21	amod	_	_
21	target	target	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	protein	protein	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	C	c	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	interleukin	interleukin	NN	NN	_	30	compound	_	_
29	2	2	CD	CD	_	30	nummod	_	_
30	promoter	promoter	NN	NN	_	18	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	Stimulation	stimulation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	antigen	antigen	NN	NN	_	1	nmod	_	_
7	results	result	VBZ	VBZ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	kinases	kinase	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	including	include	VBG	VBG	_	17	case	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	kinase	kinase	NN	NN	_	17	compound	_	_
17	C	c	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PKC	pkc	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	12	punct	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	mediate	mediate	VB	VB	_	12	acl:relcl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	later	later	JJ	JJ	_	27	amod	_	_
27	induction	induction	NN	NN	_	24	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	activation-related	activation-related	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PKC	pkc	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	induction	induction	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	interleukin	interleukin	NN	NN	_	18	compound	_	_
14	2	2	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-2	il-2	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	gene	gene	NN	NN	_	10	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	stimulated	stimulate	VBN	VBN	_	21	acl	_	_
23	through	through	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	T	t	NN	NN	_	28	compound	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	receptor/CD3	receptor/cd3	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	18	mark	_	_
6	prolonged	prolonged	JJ	JJ	_	7	amod	_	_
7	treatment	treatment	NN	NN	_	18	nsubj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	untransformed	untransformed	JJ	JJ	_	14	amod	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	clone	clone	NN	NN	_	14	compound	_	_
14	Ar-5	ar-5	NN	NN	_	7	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	phorbol	phorbol	NN	NN	_	17	compound	_	_
17	esters	ester	NNS	NNS	_	7	nmod	_	_
18	results	result	VBZ	VBZ	_	4	ccomp	_	_
19	in	in	IN	IN	_	20	case	_	_
20	downmodulation	downmodulation	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	alpha	alpha	NN	NN	_	26	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	beta	beta	NN	NN	_	23	conj	_	_
26	isozymes	isozyme	NNS	NNS	_	20	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	PKC	pkc	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	18	punct	_	_
30	and	and	CC	CC	_	18	cc	_	_
31	abrogates	abrogate	VBZ	VBZ	_	18	conj	_	_
32	induction	induction	NN	NN	_	31	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	IL-2	il-2	NN	NN	_	35	compound	_	_
35	mRNA	mrna	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	protein	protein	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	phorbol	phorbol	NN	NN	_	7	compound	_	_
6	ester	ester	NN	NN	_	7	compound	_	_
7	treatment	treatment	NN	NN	_	9	nsubj	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	abolishes	abolish	VBZ	VBZ	_	3	ccomp	_	_
10	induction	induction	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	chloramphenicol	chloramphenicol	JJ	JJ	_	14	amod	_	_
13	acetyltransferase	acetyltransferase	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Ar-5	ar-5	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	transfected	transfect	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	plasmid	plasmid	NN	NN	_	18	nmod	_	_
22	containing	contain	VBG	VBG	_	21	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-2	il-2	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	22	dobj	_	_
26	linked	link	VBN	VBN	_	25	acl	_	_
27	to	to	TO	TO	_	30	case	_	_
28	this	this	DT	DT	_	30	det	_	_
29	reporter	reporter	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sites	site	NNS	NNS	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	including	include	VBG	VBG	_	11	case	_	_
11	NFAT-1	nfat-1	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	Oct	oct	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	11	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	AP-1	ap-1	NN	NN	_	11	conj	_	_
20	,	,	,	,	_	11	punct	_	_
21	which	which	WDT	WDT	_	25	nsubj	_	_
22	are	be	VBP	VBP	_	25	cop	_	_
23	all	all	DT	DT	_	25	det	_	_
24	potentially	potentially	RB	RB	_	25	advmod	_	_
25	sensitive	sensitive	JJ	JJ	_	11	acl:relcl	_	_
26	to	to	TO	TO	_	27	case	_	_
27	activation	activation	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	PKC	pkc	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	induction	induction	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	trimer	trimer	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	NFAT	nfat	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Oct	oct	NN	NN	_	10	conj	_	_
13	sites	site	NNS	NNS	_	7	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	sensitive	sensitive	JJ	JJ	_	2	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	phorbol	phorbol	NN	NN	_	20	compound	_	_
19	ester	ester	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	that	that	IN	IN	_	30	mark	_	_
24	mutations	mutation	NNS	NNS	_	30	nsubj	_	_
25	in	in	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	24	nmod	_	_
30	have	have	VBP	VBP	_	16	conj	_	_
31	no	no	DT	DT	_	32	neg	_	_
32	effect	effect	NN	NN	_	30	dobj	_	_
33	on	on	IN	IN	_	34	case	_	_
34	inducibility	inducibility	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	IL-2	il-2	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	mutations	mutation	NNS	NNS	_	15	nsubj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	4	nmod	_	_
9	located	located	JJ	JJ	_	8	amod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	-150	-150	CD	CD	_	12	nummod	_	_
12	bp	bp	NN	NN	_	9	nmod	_	_
13	almost	almost	RB	RB	_	14	advmod	_	_
14	completely	completely	RB	RB	_	15	advmod	_	_
15	abrogate	abrogate	VBP	VBP	_	0	root	_	_
16	induction	induction	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	appearance	appearance	NN	NN	_	34	nsubj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	inducible	inducible	JJ	JJ	_	28	amod	_	_
27	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
28	factor	factor	NN	NN	_	23	nmod	_	_
29	binding	bind	VBG	VBG	_	28	acl	_	_
30	to	to	TO	TO	_	32	case	_	_
31	this	this	DT	DT	_	32	det	_	_
32	site	site	NN	NN	_	29	nmod	_	_
33	is	be	VBZ	VBZ	_	34	cop	_	_
34	sensitive	sensitive	JJ	JJ	_	15	conj	_	_
35	to	to	TO	TO	_	37	case	_	_
36	PKC	pkc	NN	NN	_	37	compound	_	_
37	depletion	depletion	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	cotransfections	cotransfection	NNS	NNS	_	11	nsubj	_	_
4	with	with	IN	IN	_	9	case	_	_
5	c-fos	c-fos	NN	NN	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-jun	c-jun	NN	NN	_	5	conj	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	plasmids	plasmid	NNS	NNS	_	3	nmod	_	_
10	markedly	markedly	RB	RB	_	11	advmod	_	_
11	enhance	enhance	VBP	VBP	_	0	root	_	_
12	induction	induction	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	minimally	minimally	RB	RB	_	19	advmod	_	_
19	stimulated	stimulate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	12	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	AP-1	ap-1	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	11	nsubj	_	_
8	at	at	IN	IN	_	10	case	_	_
9	-150	-150	CD	CD	_	10	nummod	_	_
10	bp	bp	NN	NN	_	7	nmod	_	_
11	represents	represent	VBZ	VBZ	_	3	ccomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	major	major	JJ	JJ	_	11	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	if	if	IN	IN	_	16	mark	_	_
16	not	not	RB	RB	_	13	dep	_	_
17	the	the	DT	DT	_	18	det	_	_
18	only	only	JJ	JJ	_	16	dep	_	_
19	,	,	,	,	_	16	punct	_	_
20	site	site	NN	NN	_	13	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	PKC	pkc	NN	NN	_	23	compound	_	_
23	responsiveness	responsiveness	NN	NN	_	13	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IL-2	il-2	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	13	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Interleukin	interleukin	NN	NN	_	2	nmod:npmod	_	_
2	6-induced	6-induced	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	3	nmod	_	_
10	into	into	IN	IN	_	13	case	_	_
11	IgM-secreting	igm-secreting	JJ	JJ	_	13	amod	_	_
12	plasma	plasma	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	c-fos	c-fos	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	protooncogene	protooncogene	NN	NN	_	6	compound	_	_
6	c-fos	c-fos	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	15	case	_	_
8	interleukin	interleukin	NN	NN	_	12	nmod:npmod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	IL	il	NN	NN	_	12	nmod:npmod	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	6-induced	6-induced	JJ	JJ	_	15	amod	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	2	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	assessed	assess	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Treatment	treatment	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	SKW	skw	NN	NN	_	5	compound	_	_
4	6.4	6.4	CD	CD	_	5	nummod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	IL	il	NN	NN	_	1	nmod	_	_
8	6	6	CD	CD	_	7	nummod	_	_
9	induced	induce	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	14	det	_	_
11	transient	transient	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	early	early	JJ	JJ	_	11	conj	_	_
14	stimulation	stimulation	NN	NN	_	9	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	c-fos	c-fos	NN	NN	_	19	compound	_	_
17	sense	sense	NN	NN	_	19	compound	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	3	nsubj	_	_
3	appeared	appear	VBD	VBD	_	0	root	_	_
4	within	within	IN	IN	_	6	case	_	_
5	30	30	CD	CD	_	6	nummod	_	_
6	min	min	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	returned	return	VBD	VBD	_	3	conj	_	_
9	to	to	TO	TO	_	11	case	_	_
10	basal	basal	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	2	2	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	antisense	antisense	JJ	JJ	_	5	amod	_	_
5	oligonucleotides	oligonucleotide	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	c-fos	c-fos	NN	NN	_	2	nmod	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	inhibited	inhibit	VBD	VBD	_	0	root	_	_
10	IL	il	NN	NN	_	11	nmod:npmod	_	_
11	6-induced	6-induced	JJ	JJ	_	13	amod	_	_
12	IgM	igm	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	9	dobj	_	_
14	by	by	IN	IN	_	17	case	_	_
15	SKW	skw	NN	NN	_	17	compound	_	_
16	6.4	6.4	CD	CD	_	17	nummod	_	_
17	cells	cell	NNS	NNS	_	9	nmod	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	p	p	NN	NN	_	22	dep	_	_
20	less	less	JJR	JJR	_	22	advmod	_	_
21	than	than	IN	IN	_	20	mwe	_	_
22	0.001	0.001	CD	CD	_	9	parataxis	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	9	punct	_	_
25	whereas	whereas	IN	IN	_	9	dep	_	_
26	control	control	NN	NN	_	27	compound	_	_
27	oligonucleotides	oligonucleotide	NNS	NNS	_	28	nsubj	_	_
28	had	have	VBD	VBD	_	9	parataxis	_	_
29	no	no	DT	DT	_	31	neg	_	_
30	inhibitory	inhibitory	JJ	JJ	_	31	amod	_	_
31	effect	effect	NN	NN	_	28	dobj	_	_
32	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	activation	activation	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	c-fos	c-fos	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	IL	il	NN	NN	_	12	nmod:npmod	_	_
12	6-induced	6-induced	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	SKW	skw	NN	NN	_	17	compound	_	_
16	6.4	6.4	CD	CD	_	17	nummod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	into	into	IN	IN	_	20	case	_	_
19	IgM-secreting	igm-secreting	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	non-erythroid	non-erythroid	JJ	JJ	_	3	conj	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	1	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	silencer	silencer	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	epsilon-globin-encoding	epsilon-globin-encoding	JJ	JJ	_	15	amod	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	17	dep	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	developmental	developmental	JJ	JJ	_	10	amod	_	_
10	control	control	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	hemoglobin-encoding	hemoglobin-encoding	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	we	we	PRP	PRP	_	17	nsubj	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	aux	_	_
17	studying	study	VBG	VBG	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	these	these	DT	DT	_	22	det	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	continuous	continuous	JJ	JJ	_	28	amod	_	_
28	culture	culture	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
10	control	control	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	6	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	properties	property	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	silencer	silencer	NN	NN	_	14	nmod	_	_
18	extending	extend	VBG	VBG	_	17	acl	_	_
19	from	from	IN	IN	_	20	case	_	_
20	-392	-392	CD	CD	_	23	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	-177	-177	CD	CD	_	20	nmod	_	_
23	bp	bp	NN	NN	_	18	nmod	_	_
24	relative	relative	JJ	JJ	_	28	case	_	_
25	to	to	TO	TO	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	cap	cap	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	18	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	human	human	JJ	JJ	_	33	amod	_	_
32	epsilon-globin-encoding	epsilon-globin-encoding	JJ	JJ	_	33	amod	_	_
33	gene	gene	NN	NN	_	28	nmod	_	_
34	-LSB-	-lsb-	-LRB-	-LRB-	_	35	punct	_	_
35	Cao	Cao	NNP	NNP	_	4	dep	_	_
36	et	et	FW	FW	_	35	dep	_	_
37	al.	al.	FW	FW	_	35	dep	_	_
38	,	,	,	,	_	35	punct	_	_
39	Proc.Natl.Acad.Sci.USA	Proc.Natl.Acad.Sci.USA	NNP	NNP	_	35	appos	_	_
40	86	86	CD	CD	_	39	nummod	_	_
41	(	(	-LRB-	-LRB-	_	39	punct	_	_
42	1989	1989	CD	CD	_	39	nummod	_	_
43	)	)	-RRB-	-RRB-	_	39	punct	_	_
44	5306-5309	5306-5309	CD	CD	_	39	nummod	_	_
45	-RSB-	-rsb-	-RRB-	-RRB-	_	35	punct	_	_
46	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	silencer	silencer	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	3	ccomp	_	_
8	stronger	stronger	JJR	JJR	_	10	amod	_	_
9	inhibitory	inhibitory	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HeLa	hela	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	compared	compare	VBN	VBN	_	7	advcl	_	_
17	to	to	TO	TO	_	21	case	_	_
18	K562	k562	NN	NN	_	21	compound	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	erythroleukemia	erythroleukemia	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	23	advcl	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	1	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	cis-cloned	cis-cloned	JJ	JJ	_	7	amod	_	_
6	synthetic	synthetic	JJ	JJ	_	7	amod	_	_
7	oligodeoxyribonucleotides	oligodeoxyribonucleotide	NNS	NNS	_	3	conj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	transient	transient	JJ	JJ	_	11	amod	_	_
10	expression	expression	NN	NN	_	11	compound	_	_
11	assays	assay	NNS	NNS	_	1	nmod	_	_
12	,	,	,	,	_	23	punct	_	_
13	nucleotide	nucleotide	NN	NN	_	14	compound	_	_
14	sequences	sequence	NNS	NNS	_	23	nsubjpass	_	_
15	responsible	responsible	JJ	JJ	_	14	amod	_	_
16	for	for	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	15	nmod	_	_
19	have	have	VBP	VBP	_	23	aux	_	_
20	now	now	RB	RB	_	23	advmod	_	_
21	been	be	VBN	VBN	_	23	auxpass	_	_
22	further	further	RBR	RBR	_	23	advmod	_	_
23	delimited	delimit	VBN	VBN	_	0	root	_	_
24	to	to	TO	TO	_	26	case	_	_
25	44	44	CD	CD	_	26	nummod	_	_
26	bp	bp	NN	NN	_	23	nmod	_	_
27	located	located	JJ	JJ	_	26	amod	_	_
28	from	from	IN	IN	_	29	case	_	_
29	-294	-294	CD	CD	_	32	nmod	_	_
30	to	to	TO	TO	_	31	case	_	_
31	-251	-251	CD	CD	_	29	nmod	_	_
32	bp	bp	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	23	punct	_	_

1	Gel	gel	NN	NN	_	5	compound	_	_
2	electrophoresis	electrophoresis	NN	NN	_	5	compound	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	DNaseI	dnasei	NN	NN	_	9	compound	_	_
8	footprinting	footprinting	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	5	conj	_	_
10	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	17	mark	_	_
12	these	these	DT	DT	_	15	det	_	_
13	negative	negative	JJ	JJ	_	15	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	sequences	sequence	NNS	NNS	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	recognized	recognize	VBN	VBN	_	10	ccomp	_	_
18	differently	differently	RB	RB	_	17	advmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	present	present	JJ	JJ	_	20	amod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	extracts	extract	NNS	NNS	_	21	nmod	_	_
25	obtained	obtain	VBN	VBN	_	24	acl	_	_
26	from	from	IN	IN	_	30	case	_	_
27	HeLa	hela	NN	NN	_	30	compound	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	K562	k562	NN	NN	_	27	conj	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	K562	k562	NN	NN	_	9	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	extracts	extract	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	while	while	IN	IN	_	15	mark	_	_
12	only	only	RB	RB	_	13	advmod	_	_
13	one	one	CD	CD	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	5	advcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	extracts	extract	NNS	NNS	_	15	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	HeLa	hela	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Possible	possible	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	20	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	8	nmod	_	_
5	these	these	DT	DT	_	6	det	_	_
6	proteins	protein	NNS	NNS	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	regulate	regulate	VB	VB	_	2	acl:relcl	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	epsilon-globin-encoding	epsilon-globin-encoding	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	non-erythroid	non-erythroid	JJ	JJ	_	15	conj	_	_
18	cells	cell	NNS	NNS	_	9	nmod	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	discussed	discuss	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Gangliosides	gangliosides	NN	NN	_	2	nsubj	_	_
2	suppress	suppress	VBP	VBP	_	0	root	_	_
3	tumor	tumor	NN	NN	_	6	compound	_	_
4	necrosis	necrosis	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	normal	normal	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	malignant	malignant	JJ	JJ	_	2	conj	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	contain	contain	VBP	VBP	_	0	root	_	_
7	gangliosides	ganglioside	NNS	NNS	_	6	dobj	_	_
8	as	as	IN	IN	_	12	case	_	_
9	important	important	JJ	JJ	_	12	amod	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	membrane	membrane	NN	NN	_	12	compound	_	_
12	constituents	constituent	NNS	NNS	_	6	nmod	_	_
13	that	that	WDT	WDT	_	20	nsubj	_	_
14	,	,	,	,	_	20	punct	_	_
15	after	after	IN	IN	_	17	mark	_	_
16	being	be	VBG	VBG	_	17	auxpass	_	_
17	shed	shed	VBN	VBN	_	20	advcl	_	_
18	,	,	,	,	_	20	punct	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	influence	influence	VB	VB	_	12	acl:relcl	_	_
21	cells	cell	NNS	NNS	_	20	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	immune	immune	JJ	JJ	_	25	amod	_	_
25	system	system	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	impact	impact	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	gangliosides	ganglioside	NNS	NNS	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TNF	tnf	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	in	in	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
20	cell	cell	NN	NN	_	23	compound	_	_
21	line	line	NN	NN	_	23	compound	_	_
22	Mono	mono	NN	NN	_	23	compound	_	_
23	Mac	mac	NN	NN	_	15	conj	_	_
24	6	6	CD	CD	_	23	nummod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	14	mark	_	_
2	under	under	IN	IN	_	5	case	_	_
3	standard	standard	JJ	JJ	_	5	amod	_	_
4	culture	culture	NN	NN	_	5	compound	_	_
5	conditions	condition	NNS	NNS	_	14	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	bovine	bovine	JJ	JJ	_	9	amod	_	_
8	brain	brain	NN	NN	_	9	compound	_	_
9	gangliosides	ganglioside	NNS	NNS	_	14	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	100	100	CD	CD	_	12	nummod	_	_
12	micrograms/ml	micrograms/ml	NNS	NNS	_	9	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	suppressed	suppress	VBD	VBD	_	32	advcl	_	_
15	LPS-stimulated	lps-stimulated	JJ	JJ	_	17	amod	_	_
16	TNF	tnf	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	dobj	_	_
18	5-fold	5-fold	RB	RB	_	14	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	PBMC	pbmc	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	10-fold	10-fold	RB	RB	_	14	conj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	Mono	mono	NN	NN	_	27	compound	_	_
25	Mac	mac	NN	NN	_	27	compound	_	_
26	6	6	CD	CD	_	27	nummod	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	,	,	,	,	_	32	punct	_	_
29	suppression	suppression	NN	NN	_	32	nsubj	_	_
30	was	be	VBD	VBD	_	32	cop	_	_
31	more	more	RBR	RBR	_	32	advmod	_	_
32	efficient	efficient	JJ	JJ	_	0	root	_	_
33	under	under	IN	IN	_	35	case	_	_
34	serum-free	serum-free	JJ	JJ	_	35	amod	_	_
35	conditions	condition	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	32	punct	_	_

1	Looking	look	VBG	VBG	_	19	advcl	_	_
2	at	at	IN	IN	_	5	case	_	_
3	highly	highly	RB	RB	_	4	advmod	_	_
4	purified	purify	VBN	VBN	_	5	amod	_	_
5	gangliosides	ganglioside	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	19	punct	_	_
7	GD3	gd3	NN	NN	_	19	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	GD1a	gd1a	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	GM3	gm3	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	GM2	gm2	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	GM1	gm1	NN	NN	_	7	conj	_	_
17	were	be	VBD	VBD	_	19	cop	_	_
18	all	all	DT	DT	_	19	det	_	_
19	effective	effective	JJ	JJ	_	0	root	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	reducing	reduce	VBG	VBG	_	19	advcl	_	_
22	TNF	tnf	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	PBMC	pbmc	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	in	in	IN	IN	_	30	case	_	_
29	Mono	mono	NN	NN	_	30	compound	_	_
30	Mac	mac	NN	NN	_	25	conj	_	_
31	6	6	CD	CD	_	30	nummod	_	_
32	by	by	IN	IN	_	33	case	_	_
33	factor	factor	NN	NN	_	23	nmod	_	_
34	10	10	CD	CD	_	33	dep	_	_
35	to	to	TO	TO	_	34	dep	_	_
36	50	50	CD	CD	_	34	dep	_	_
37	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	suppressive	suppressive	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	lost	lose	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	molecules	molecule	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	lacking	lack	VBG	VBG	_	5	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	sugar	sugar	NN	NN	_	12	compound	_	_
12	moiety	moiety	NN	NN	_	9	dobj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	lipid	lipid	NN	NN	_	16	compound	_	_
16	moiety	moiety	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	Gangliosides	ganglioside	NNS	NNS	_	2	nsubj	_	_
2	appear	appear	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	act	act	VB	VB	_	2	xcomp	_	_
5	at	at	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	early	early	JJ	JJ	_	8	amod	_	_
8	step	step	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	that	that	IN	IN	_	16	nmod	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	transcripts	transcript	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	reduced	reduce	VBN	VBN	_	8	acl:relcl	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	mobilization	mobilization	NN	NN	_	27	nsubjpass	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	19	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	blocked	block	VBN	VBN	_	16	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	time	time	NN	NN	_	5	compound	_	_
5	kinetics	kinetics	NNS	NNS	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	gangliosides	ganglioside	NNS	NNS	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	effective	effective	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	14	case	_	_
11	up	up	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	30	30	CD	CD	_	14	nummod	_	_
14	min	min	NN	NN	_	9	dep	_	_
15	after	after	IN	IN	_	16	case	_	_
16	addition	addition	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	LPS	lps	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	but	but	CC	CC	_	14	cc	_	_
21	not	not	RB	RB	_	22	dep	_	_
22	thereafter	thereafter	RB	RB	_	14	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	20	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CD14	cd14	NN	NN	_	8	compound	_	_
8	Ag	ag	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	molecule	molecule	NN	NN	_	8	appos	_	_
13	for	for	IN	IN	_	17	case	_	_
14	LPS-LPS	lps-lps	NN	NN	_	17	compound	_	_
15	binding	binding	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	complexes	complex	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	was	be	VBD	VBD	_	20	aux	_	_
20	unaffected	unaffected	JJ	JJ	_	0	root	_	_
21	by	by	IN	IN	_	22	case	_	_
22	gangliosides	ganglioside	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	20	punct	_	_

1	Finally	finally	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	when	when	WRB	WRB	_	4	advmod	_	_
4	using	use	VBG	VBG	_	17	advcl	_	_
5	Staphylococcus	staphylococcus	FW	FW	_	6	compound	_	_
6	aureus	aureus	FW	FW	_	4	dobj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	platelet	platelet	NN	NN	_	10	compound	_	_
9	activating	activating	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	conj	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	stimulus	stimulus	NN	NN	_	4	nmod	_	_
14	,	,	,	,	_	17	punct	_	_
15	gangliosides	ganglioside	NNS	NNS	_	17	nsubj	_	_
16	were	be	VBD	VBD	_	17	cop	_	_
17	able	able	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	suppress	suppress	VB	VB	_	17	xcomp	_	_
20	TNF	tnf	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	Mono	mono	NN	NN	_	26	compound	_	_
24	Mac	mac	NN	NN	_	26	compound	_	_
25	6	6	CD	CD	_	26	nummod	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	factor	factor	NN	NN	_	19	nmod	_	_
29	5	5	CD	CD	_	28	dep	_	_
30	to	to	TO	TO	_	29	dep	_	_
31	10	10	CD	CD	_	29	dep	_	_
32	,	,	,	,	_	19	punct	_	_
33	as	as	RB	RB	_	34	advmod	_	_
34	well	well	RB	RB	_	19	advcl	_	_
35	.	.	.	.	_	17	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	phorbol	phorbol	NN	NN	_	7	nmod:npmod	_	_
7	ester-induced	ester-induced	JJ	JJ	_	8	amod	_	_
8	production	production	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	O2-	o2-	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	similar	similar	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	cells	cell	NNS	NNS	_	12	nmod	_	_
15	treated	treat	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	19	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	without	without	IN	IN	_	16	conj	_	_
19	gangliosides	ganglioside	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	21	mark	_	_
8	TNF	tnf	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	21	nsubjpass	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	induced	induce	VBN	VBN	_	10	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	types	type	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	stimuli	stimulus	NNS	NNS	_	16	nmod	_	_
19	can	can	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	blocked	block	VBN	VBN	_	6	ccomp	_	_
22	by	by	IN	IN	_	23	case	_	_
23	gangliosides	ganglioside	NNS	NNS	_	21	nmod	_	_
24	at	at	IN	IN	_	27	case	_	_
25	an	a	DT	DT	_	27	det	_	_
26	early	early	JJ	JJ	_	27	amod	_	_
27	step	step	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	signal	signal	JJ	JJ	_	30	amod	_	_
30	transduction	transduction	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	T	t	NN	NN	_	2	nmod:npmod	_	_
2	cell-specific	cell-specific	JJ	JJ	_	4	amod	_	_
3	negative	negative	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	transcription	transcription	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	IL-4	il-4	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	IL-4	il-4	NN	NN	_	10	nsubj	_	_
2	secreted	secrete	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	pleiotropic	pleiotropic	JJ	JJ	_	10	amod	_	_
10	cytokine	cytokine	NN	NN	_	0	root	_	_
11	affecting	affect	VBG	VBG	_	10	acl	_	_
12	growth	growth	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	differentiation	differentiation	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	diverse	diverse	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	12	nmod	_	_
19	such	such	JJ	JJ	_	22	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	mast	mast	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	conj	_	_
30	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	upstream	upstream	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	2	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	IL-4	il-4	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	novel	novel	JJ	JJ	_	7	amod	_	_
3	T	t	NN	NN	_	4	nmod:npmod	_	_
4	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
5	negative	negative	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	17	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NRE	nre	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	composed	compose	VBN	VBN	_	7	acl	_	_
12	of	of	IN	IN	_	15	case	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	protein-binding	protein-binding	JJ	JJ	_	15	amod	_	_
15	sites	site	NNS	NNS	_	11	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	mapped	map	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	5'	5'	JJ	JJ	_	22	amod	_	_
21	flanking	flanking	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IL-4	il-4	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	:	:	:	:	_	17	punct	_	_
28	-311CTCCCTTCT-303	-311ctcccttct-303	NN	NN	_	17	dobj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	NRE-I	nre-i	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	-288CTTTTTGCTT-TGC-300	-288ctttttgctt-tgc-300	NN	NN	_	28	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	NRE-II	nre-ii	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	T	t	NN	NN	_	3	nmod:npmod	_	_
3	cell-specific	cell-specific	JJ	JJ	_	5	amod	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	Neg-1	neg-1	NN	NN	_	20	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	a	a	DT	DT	_	10	det	_	_
8	ubiquitous	ubiquitous	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	Neg-2	neg-2	NN	NN	_	5	conj	_	_
11	binding	bind	VBG	VBG	_	5	acl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	NRE-I	nre-i	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NRE-II	nre-ii	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	respectively	respectively	RB	RB	_	11	advmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	identified	identify	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	positive	positive	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	45	45	CD	CD	_	10	nummod	_	_
10	bp	bp	NN	NN	_	11	nmod:npmod	_	_
11	downstream	downstream	RB	RB	_	8	advmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	NRE	nre	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	enhancer	enhancer	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	PRE	pre	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	suppressed	suppress	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	NRE	nre	NN	NN	_	14	nsubj	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	present	present	JJ	JJ	_	9	advcl	_	_
15	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	IL-4	il-4	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	normally	normally	RB	RB	_	10	advmod	_	_
10	down-regulated	down-regulate	VBN	VBN	_	3	ccomp	_	_
11	by	by	IN	IN	_	13	case	_	_
12	an	a	DT	DT	_	13	det	_	_
13	NRE	nre	NN	NN	_	10	nmod	_	_
14	via	via	IN	IN	_	15	case	_	_
15	repression	repression	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	enhancer	enhancer	NN	NN	_	21	compound	_	_
19	positive	positive	JJ	JJ	_	21	amod	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	element	element	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	implications	implication	NNS	NNS	_	4	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	stringent	stringent	JJ	JJ	_	9	amod	_	_
9	control	control	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-4	il-4	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	insulin	insulin	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	21	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	insulin	insulin	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	specific	specific	JJ	JJ	_	10	amod	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	power	power	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GR	gr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	of	of	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	leukocytes	leukocyte	NNS	NNS	_	13	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	assessed	assess	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	unoccupied	unoccupied	JJ	JJ	_	26	amod	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	21	nmod	_	_
27	capable	capable	JJ	JJ	_	26	amod	_	_
28	of	of	IN	IN	_	29	mark	_	_
29	combining	combine	VBG	VBG	_	27	advcl	_	_
30	with	with	IN	IN	_	33	case	_	_
31	-LSB-3H-RSB-	-lsb-3h-rsb-	NN	NN	_	33	compound	_	_
32	labelled	labelled	JJ	JJ	_	33	amod	_	_
33	dexamethasone	dexamethasone	NN	NN	_	29	nmod	_	_
34	measured	measure	VBN	VBN	_	33	acl	_	_
35	at	at	IN	IN	_	39	case	_	_
36	3	3	CD	CD	_	39	nummod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	24	24	CD	CD	_	36	conj	_	_
39	h	h	NN	NN	_	34	nmod	_	_
40	after	after	IN	IN	_	41	case	_	_
41	incubation	incubation	NN	NN	_	39	nmod	_	_
42	with	with	IN	IN	_	44	case	_	_
43	various	various	JJ	JJ	_	44	amod	_	_
44	concentrations	concentration	NNS	NNS	_	41	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	insulin	insulin	NN	NN	_	44	nmod	_	_
47	added	add	VBN	VBN	_	44	acl	_	_
48	to	to	TO	TO	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	medium	medium	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	21	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	3	3	CD	CD	_	3	compound	_	_
3	h	h	NN	NN	_	4	amod	_	_
4	incubation	incubation	NN	NN	_	13	nmod	_	_
5	the	the	DT	DT	_	8	det	_	_
6	specific	specific	JJ	JJ	_	8	amod	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	power	power	NN	NN	_	13	nsubjpass	_	_
9	with	with	IN	IN	_	11	case	_	_
10	-LSB-3H-RSB-	-lsb-3h-rsb-	NN	NN	_	11	compound	_	_
11	Dex	dex	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	decreased	decrease	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	23.3	23.3	CD	CD	_	13	nmod	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	10.0	10.0	CD	CD	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	32.2	32.2	CD	CD	_	15	conj	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	13.2	13.2	CD	CD	_	19	conj	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	54.3	54.3	CD	CD	_	15	conj	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	9.2	9.2	CD	CD	_	23	conj	_	_
26	%	%	NN	NN	_	15	dep	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	P	p	NN	NN	_	15	dep	_	_
29	greater	greater	JJR	JJR	_	28	amod	_	_
30	than	than	IN	IN	_	31	case	_	_
31	0.05	0.05	CD	CD	_	29	nmod	_	_
32	,	,	,	,	_	28	punct	_	_
33	P	p	NN	NN	_	28	conj	_	_
34	greater	greater	JJR	JJR	_	33	amod	_	_
35	than	than	IN	IN	_	36	case	_	_
36	0.05	0.05	CD	CD	_	34	nmod	_	_
37	and	and	CC	CC	_	28	cc	_	_
38	P	p	NN	NN	_	28	conj	_	_
39	less	less	JJR	JJR	_	38	amod	_	_
40	than	than	IN	IN	_	41	case	_	_
41	0.01	0.01	CD	CD	_	39	nmod	_	_
42	as	as	IN	IN	_	43	mark	_	_
43	compared	compare	VBN	VBN	_	28	dep	_	_
44	with	with	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	control	control	NN	NN	_	47	compound	_	_
47	value	value	NN	NN	_	43	nmod	_	_
48	of	of	IN	IN	_	49	case	_	_
49	100	100	CD	CD	_	47	nmod	_	_
50	in	in	IN	IN	_	54	case	_	_
51	the	the	DT	DT	_	54	dep	_	_
52	absence	absence	NN	NN	_	54	dep	_	_
53	of	of	IN	IN	_	54	case	_	_
54	insulin	insulin	NN	NN	_	47	nmod	_	_
55	)	)	-RRB-	-RRB-	_	28	punct	_	_
56	respectively	respectively	RB	RB	_	13	advmod	_	_
57	in	in	IN	IN	_	83	case	_	_
58	the	the	DT	DT	_	83	dep	_	_
59	presence	presence	NN	NN	_	83	dep	_	_
60	of	of	IN	IN	_	83	case	_	_
61	20	20	CD	CD	_	62	nummod	_	_
62	mU/L	mu/l	NN	NN	_	83	compound	_	_
63	(	(	-LRB-	-LRB-	_	66	punct	_	_
64	physiological	physiological	JJ	JJ	_	66	amod	_	_
65	testing	testing	NN	NN	_	66	compound	_	_
66	concentration	concentration	NN	NN	_	62	appos	_	_
67	)	)	-RRB-	-RRB-	_	66	punct	_	_
68	,	,	,	,	_	62	punct	_	_
69	200	200	CD	CD	_	70	nummod	_	_
70	mU/L	mu/l	NN	NN	_	62	conj	_	_
71	(	(	-LRB-	-LRB-	_	74	punct	_	_
72	physiological	physiological	JJ	JJ	_	74	amod	_	_
73	upper	upper	JJ	JJ	_	74	amod	_	_
74	limit	limit	NN	NN	_	70	appos	_	_
75	)	)	-RRB-	-RRB-	_	74	punct	_	_
76	and	and	CC	CC	_	62	cc	_	_
77	2,000	2,000	CD	CD	_	78	nummod	_	_
78	mU/L	mu/l	NN	NN	_	62	conj	_	_
79	(	(	-LRB-	-LRB-	_	81	punct	_	_
80	pharmacological	pharmacological	JJ	JJ	_	81	amod	_	_
81	concentration	concentration	NN	NN	_	78	appos	_	_
82	)	)	-RRB-	-RRB-	_	81	punct	_	_
83	insulin	insulin	NN	NN	_	13	nmod	_	_
84	in	in	IN	IN	_	87	case	_	_
85	the	the	DT	DT	_	87	det	_	_
86	incubation	incubation	NN	NN	_	87	compound	_	_
87	medium	medium	NN	NN	_	83	nmod	_	_
88	.	.	.	.	_	13	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	24	24	CD	CD	_	3	compound	_	_
3	h	h	NN	NN	_	4	amod	_	_
4	incubation	incubation	NN	NN	_	10	nmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	decrease	decrease	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	values	value	NNS	NNS	_	6	nmod	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	respectively	respectively	RB	RB	_	10	advmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	43.5	43.5	CD	CD	_	10	nmod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	19.0	19.0	CD	CD	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	56.1	56.1	CD	CD	_	13	conj	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	20.7	20.7	CD	CD	_	17	conj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	80.2	80.2	CD	CD	_	13	conj	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	15.5	15.5	CD	CD	_	21	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	P	p	NN	NN	_	13	dep	_	_
26	less	less	JJR	JJR	_	25	amod	_	_
27	than	than	IN	IN	_	28	case	_	_
28	0.05	0.05	CD	CD	_	26	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	P	p	NN	NN	_	25	conj	_	_
31	less	less	JJR	JJR	_	30	amod	_	_
32	than	than	IN	IN	_	33	case	_	_
33	0.01	0.01	CD	CD	_	31	nmod	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	P	p	NN	NN	_	25	conj	_	_
36	less	less	JJR	JJR	_	35	amod	_	_
37	than	than	IN	IN	_	38	case	_	_
38	0.01	0.01	CD	CD	_	36	nmod	_	_
39	compared	compare	VBN	VBN	_	25	dep	_	_
40	with	with	IN	IN	_	41	case	_	_
41	control	control	NN	NN	_	39	nmod	_	_
42	)	)	-RRB-	-RRB-	_	25	punct	_	_
43	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	inhibitory	inhibitory	JJ	JJ	_	4	amod	_	_
4	effect	effect	NN	NN	_	14	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	insulin	insulin	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	GR	gr	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	power	power	NN	NN	_	4	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	both	both	CC	CC	_	14	dep	_	_
14	dose-	dose-	NN	NN	_	0	root	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	time-dependent	time-dependent	JJ	JJ	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	strongly	strongly	RB	RB	_	20	advmod	_	_
20	suggests	suggest	VBZ	VBZ	_	14	ccomp	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	GR	gr	NN	NN	_	25	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	tonically	tonically	RB	RB	_	25	advmod	_	_
25	controlled	control	VBN	VBN	_	20	ccomp	_	_
26	by	by	IN	IN	_	29	case	_	_
27	insulin	insulin	NN	NN	_	29	compound	_	_
28	concentration	concentration	NN	NN	_	29	compound	_	_
29	change	change	NN	NN	_	25	nmod	_	_
30	under	under	IN	IN	_	32	case	_	_
31	physiological	physiological	JJ	JJ	_	32	amod	_	_
32	conditions	condition	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	9	nsubj	_	_
5	through	through	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	activation-inducer	activation-inducer	JJ	JJ	_	8	amod	_	_
8	molecule/CD69	molecule/cd69	NN	NN	_	4	nmod	_	_
9	enhances	enhance	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	AP-1	ap-1	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	AP-1	ap-1	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	ascribed	ascribe	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	events	event	NNS	NNS	_	10	nmod	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cell	cell	NN	NN	_	15	nmod	_	_
19	differentiation	differentiation	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	activation	activation	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
15	stimulated	stimulate	VBN	VBN	_	14	acl	_	_
16	through	through	IN	IN	_	26	case	_	_
17	the	the	DT	DT	_	26	det	_	_
18	activation	activation	NN	NN	_	26	compound	_	_
19	inducer	inducer	NN	NN	_	26	compound	_	_
20	molecule	molecule	NN	NN	_	26	compound	_	_
21	(	(	-LRB-	-LRB-	_	26	punct	_	_
22	AIM	aim	NN	NN	_	26	compound	_	_
23	)	)	-RRB-	-RRB-	_	26	punct	_	_
24	/CD69	/cd69	NN	NN	_	26	compound	_	_
25	activation	activation	NN	NN	_	26	compound	_	_
26	pathway	pathway	NN	NN	_	15	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	esters	ester	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	induce	induce	VB	VB	_	4	dep	_	_
7	AIM/CD69	aim/cd69	NN	NN	_	9	compound	_	_
8	cell-surface	cell-surface	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	as	as	RB	RB	_	6	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	for	for	IN	IN	_	14	mark	_	_
14	triggering	trigger	VBG	VBG	_	6	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	proliferation	proliferation	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	conjunction	conjunction	NN	NN	_	24	dep	_	_
22	with	with	IN	IN	_	24	case	_	_
23	anti-AIM	anti-aim	JJ	JJ	_	24	amod	_	_
24	mAb	mab	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Mobility	mobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	addition	addition	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	anti-AIM	anti-aim	JJ	JJ	_	9	amod	_	_
9	mAb	mab	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	PMA-treated	pma-treated	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
14	markedly	markedly	RB	RB	_	15	advmod	_	_
15	enhanced	enhance	VBD	VBD	_	4	ccomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	AP-1	ap-1	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	cognate	cognate	JJ	JJ	_	24	amod	_	_
24	sequence	sequence	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	the	the	DT	DT	_	30	det	_	_
27	phorbol	phorbol	NN	NN	_	30	compound	_	_
28	ester	ester	NN	NN	_	30	compound	_	_
29	response	response	NN	NN	_	30	compound	_	_
30	element	element	NN	NN	_	24	appos	_	_
31	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	anti-AIM	anti-aim	NN	NN	_	5	compound	_	_
5	mAb	mab	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	induce	induce	VB	VB	_	0	root	_	_
9	any	any	DT	DT	_	10	det	_	_
10	change	change	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	17	appos	_	_
22	whose	whose	WP$	WP$	_	23	nmod:poss	_	_
23	activity	activity	NN	NN	_	26	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	regulated	regulate	VBN	VBN	_	21	acl:relcl	_	_
27	by	by	IN	IN	_	30	case	_	_
28	protein	protein	NN	NN	_	30	compound	_	_
29	kinase	kinase	NN	NN	_	30	compound	_	_
30	C	c	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	AP-1-binding	ap-1-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	accompanied	accompany	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	marked	marked	JJ	JJ	_	11	amod	_	_
11	stimulation	stimulation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	transcription	transcription	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	c-fos	c-fos	NN	NN	_	14	nmod	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	14	cc	_	_
19	that	that	DT	DT	_	14	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	c-jun	c-jun	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Blockade	blockade	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	complexes	complex	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	anti-Fos	anti-fos	JJ	JJ	_	9	amod	_	_
9	mAb	mab	NN	NN	_	1	nmod	_	_
10	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	direct	direct	JJ	JJ	_	13	amod	_	_
13	participation	participation	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	c-Fos	c-fos	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	AP-1	ap-1	NN	NN	_	19	compound	_	_
19	complexes	complex	NNS	NNS	_	13	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	anti-AIM	anti-aim	NN	NN	_	23	compound	_	_
23	mAb	mab	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Most	most	JJS	JJS	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	AP-1	ap-1	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	eliminated	eliminate	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	14	advmod	_	_
10	the	the	DT	DT	_	12	det	_	_
11	anti-AIM	anti-aim	NN	NN	_	12	compound	_	_
12	mAb	mab	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	added	add	VBN	VBN	_	8	advcl	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	culture	culture	NN	NN	_	18	compound	_	_
18	medium	medium	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	dep	_	_
21	presence	presence	NN	NN	_	23	dep	_	_
22	of	of	IN	IN	_	23	case	_	_
23	cycloheximide	cycloheximide	NN	NN	_	14	nmod	_	_
24	,	,	,	,	_	8	punct	_	_
25	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
26	that	that	IN	IN	_	32	mark	_	_
27	de	de	FW	FW	_	30	amod	_	_
28	novo	novo	FW	FW	_	27	dep	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	synthesis	synthesis	NN	NN	_	32	nsubj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	crucial	crucial	JJ	JJ	_	25	ccomp	_	_
33	for	for	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	induction	induction	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	AP-1-binding	ap-1-binding	JJ	JJ	_	38	amod	_	_
38	activity	activity	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	activation	activation	NN	NN	_	19	dep	_	_
8	of	of	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	through	through	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	AIM	aim	NN	NN	_	18	compound	_	_
17	activation	activation	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	7	nmod	_	_
19	regulate	regulate	VBP	VBP	_	5	ccomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activity	activity	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	AP-1	ap-1	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	pathway	pathway	NN	NN	_	5	nsubj	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	crucial	crucial	JJ	JJ	_	9	amod	_	_
9	step	step	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	initiation	initiation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	early	early	JJ	JJ	_	18	amod	_	_
15	T	t	NN	NN	_	18	compound	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	activation	activation	NN	NN	_	18	compound	_	_
18	events	event	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	cis-acting	cis-acting	JJ	JJ	_	2	amod	_	_
2	sequences	sequence	NNS	NNS	_	9	nsubj	_	_
3	required	require	VBN	VBN	_	2	acl	_	_
4	for	for	IN	IN	_	8	case	_	_
5	inducible	inducible	JJ	JJ	_	8	amod	_	_
6	interleukin-2	interleukin-2	NN	NN	_	8	compound	_	_
7	enhancer	enhancer	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	3	nmod	_	_
9	bind	bind	VBP	VBP	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	novel	novel	JJ	JJ	_	13	amod	_	_
12	Ets-related	ets-related	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	9	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	Elf-1	elf-1	NN	NN	_	13	appos	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	definition	definition	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	consensus	consensus	NN	NN	_	9	compound	_	_
7	DNA	dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	3	nmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Ets	ets	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	has	have	VBZ	VBZ	_	18	aux	_	_
18	allowed	allow	VBN	VBN	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	identification	identification	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	potential	potential	JJ	JJ	_	25	amod	_	_
23	Ets	ets	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	sites	site	NNS	NNS	_	20	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	promoters	promoter	NNS	NNS	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	enhancers	enhancer	NNS	NNS	_	28	conj	_	_
31	of	of	IN	IN	_	35	case	_	_
32	many	many	JJ	JJ	_	35	amod	_	_
33	inducible	inducible	JJ	JJ	_	35	amod	_	_
34	T-cell	t-cell	NN	NN	_	35	compound	_	_
35	genes	gene	NNS	NNS	_	28	nmod	_	_
36	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	studies	study	NNS	NNS	_	11	nmod	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	report	report	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	we	we	PRP	PRP	_	11	nsubj	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	two	two	CD	CD	_	16	nummod	_	_
13	potential	potential	JJ	JJ	_	16	amod	_	_
14	Ets	et	NNS	NNS	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	11	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	EBS1	ebs1	NN	NN	_	16	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	EBS2	ebs2	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	which	which	WDT	WDT	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	conserved	conserve	VBN	VBN	_	16	acl:relcl	_	_
25	in	in	IN	IN	_	32	case	_	_
26	both	both	CC	CC	_	32	dep	_	_
27	the	the	DT	DT	_	32	det	_	_
28	human	human	JJ	JJ	_	32	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	murine	murine	JJ	JJ	_	28	conj	_	_
31	interleukin-2	interleukin-2	NN	NN	_	32	compound	_	_
32	enhancers	enhancer	NNS	NNS	_	24	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	Within	within	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	enhancer	enhancer	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	these	these	DT	DT	_	8	det	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	sites	site	NNS	NNS	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	located	located	JJ	JJ	_	0	root	_	_
11	within	within	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	previously	previously	RB	RB	_	14	advmod	_	_
14	defined	define	VBN	VBN	_	17	amod	_	_
15	DNase	dnase	NN	NN	_	17	compound	_	_
16	I	i	CD	CD	_	17	nummod	_	_
17	footprints	footprint	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	NFAT-1	nfat-1	NN	NN	_	17	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NFIL-2B	nfil-2b	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	respectively	respectively	RB	RB	_	10	advmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
2	mobility	mobility	NN	NN	_	3	compound	_	_
3	shift	shift	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	methylation	methylation	NN	NN	_	6	compound	_	_
6	interference	interference	NN	NN	_	3	conj	_	_
7	analyses	analysis	NNS	NNS	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	EBS1	ebs1	NN	NN	_	14	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	EBS2	ebs2	NN	NN	_	10	conj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	essential	essential	JJ	JJ	_	8	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	formation	formation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	25	case	_	_
19	the	the	DT	DT	_	25	det	_	_
20	NFAT-1	nfat-1	NN	NN	_	25	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NFIL-2B	nfil-2b	NN	NN	_	20	conj	_	_
23	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	complexes	complex	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	mutagenesis	mutagenesis	NN	NN	_	6	compound	_	_
6	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	inducible	inducible	JJ	JJ	_	12	amod	_	_
10	interleukin-2	interleukin-2	NN	NN	_	12	compound	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	function	function	NN	NN	_	13	nsubj	_	_
13	requires	require	VBZ	VBZ	_	7	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	either	either	CC	CC	_	18	cc:preconj	_	_
18	EBS1	ebs1	NN	NN	_	15	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	EBS2	ebs2	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	well-characterized	well-characterized	JJ	JJ	_	5	amod	_	_
3	Ets	ets	NN	NN	_	5	compound	_	_
4	family	family	NN	NN	_	5	compound	_	_
5	members	member	NNS	NNS	_	13	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	Ets-1	ets-1	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Ets-2	ets-2	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	are	be	VBP	VBP	_	13	auxpass	_	_
12	reciprocally	reciprocally	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	during	during	IN	IN	_	16	case	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	however	however	RB	RB	_	9	advmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	neither	neither	DT	DT	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	bound	bind	VBD	VBD	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	EBS1	ebs1	NN	NN	_	9	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	EBS2	ebs2	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	screened	screen	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	T-cell	t-cell	NN	NN	_	7	compound	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	library	library	NN	NN	_	3	dobj	_	_
8	under	under	IN	IN	_	10	case	_	_
9	low-stringency	low-stringency	NN	NN	_	10	compound	_	_
10	conditions	condition	NNS	NNS	_	3	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	probe	probe	NN	NN	_	3	nmod	_	_
14	from	from	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Ets-1	ets-1	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	3	cc	_	_
22	isolated	isolate	VBD	VBD	_	3	conj	_	_
23	a	a	DT	DT	_	27	det	_	_
24	novel	novel	JJ	JJ	_	27	amod	_	_
25	Ets	ets	NN	NN	_	27	compound	_	_
26	family	family	NN	NN	_	27	compound	_	_
27	member	member	NN	NN	_	22	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	Elf-1	elf-1	NN	NN	_	27	appos	_	_
30	.	.	.	.	_	3	punct	_	_

1	Elf-1	elf-1	NN	NN	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	2	dobj	_	_
7	that	that	WDT	WDT	_	10	nsubj	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	nearly	nearly	RB	RB	_	10	advmod	_	_
10	identical	identical	JJ	JJ	_	6	acl:relcl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	E74	e74	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	20	det	_	_
17	ecdysone-inducible	ecdysone-inducible	JJ	JJ	_	20	amod	_	_
18	Drosophila	drosophila	NN	NN	_	20	compound	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	14	appos	_	_
21	required	require	VBN	VBN	_	20	acl	_	_
22	for	for	IN	IN	_	23	case	_	_
23	metamorphosis	metamorphosis	NN	NN	_	21	nmod	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	hence	hence	RB	RB	_	28	dep	_	_
26	the	the	DT	DT	_	28	det	_	_
27	name	name	NN	NN	_	28	compound	_	_
28	Elf-1	elf-1	NN	NN	_	2	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	for	for	IN	IN	_	32	case	_	_
31	E74-like	e74-like	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	28	nmod	_	_
33	1	1	CD	CD	_	32	nummod	_	_
34	)	)	-RRB-	-RRB-	_	28	punct	_	_
35	.	.	.	.	_	2	punct	_	_

1	Elf-1	elf-1	NN	NN	_	2	nsubj	_	_
2	bound	bind	VBD	VBD	_	0	root	_	_
3	specifically	specifically	RB	RB	_	6	advmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	EBS1	ebs1	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	EBS2	ebs2	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	electrophoretic	electrophoretic	JJ	JJ	_	13	amod	_	_
11	mobility	mobility	NN	NN	_	13	compound	_	_
12	shift	shift	NN	NN	_	13	compound	_	_
13	assays	assay	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	bound	bind	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	purine-rich	purine-rich	JJ	JJ	_	8	amod	_	_
7	CD3R	cd3r	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	3	nmod	_	_
9	from	from	IN	IN	_	18	case	_	_
10	the	the	DT	DT	_	18	det	_	_
11	human	human	JJ	JJ	_	18	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
13	virus	virus	NN	NN	_	18	compound	_	_
14	type	type	NN	NN	_	18	compound	_	_
15	2	2	CD	CD	_	18	nummod	_	_
16	long	long	JJ	JJ	_	18	amod	_	_
17	terminal	terminal	JJ	JJ	_	18	amod	_	_
18	repeat	repeat	NN	NN	_	8	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	which	which	WDT	WDT	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	required	require	VBN	VBN	_	18	acl:relcl	_	_
23	for	for	IN	IN	_	26	case	_	_
24	inducible	inducible	JJ	JJ	_	26	amod	_	_
25	virus	virus	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	response	response	NN	NN	_	30	dep	_	_
29	to	to	TO	TO	_	30	case	_	_
30	signalling	signalling	NN	NN	_	26	nmod	_	_
31	through	through	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	T-cell	t-cell	NN	NN	_	34	compound	_	_
34	receptor	receptor	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	multiple	multiple	JJ	JJ	_	11	amod	_	_
9	Ets	ets	NN	NN	_	11	compound	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	18	nsubj	_	_
12	with	with	IN	IN	_	17	case	_	_
13	apparently	apparently	RB	RB	_	14	advmod	_	_
14	distinct	distinct	JJ	JJ	_	17	amod	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	specificities	specificity	NNS	NNS	_	11	nmod	_	_
18	regulate	regulate	VBP	VBP	_	6	ccomp	_	_
19	differential	differential	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	27	case	_	_
23	resting	rest	VBG	VBG	_	27	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	activated	activate	VBN	VBN	_	23	conj	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	0	root	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	in	in	FW	FW	_	1	conj	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	effects	effect	NNS	NNS	_	1	dep	_	_
7	of	of	IN	IN	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	proliferation	proliferation	NN	NN	_	1	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	man	man	NN	NN	_	11	nmod	_	_
14	:	:	:	:	_	1	punct	_	_
15	relationship	relationship	NN	NN	_	1	dep	_	_
16	to	to	TO	TO	_	18	case	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Interrelations	interrelation	NNS	NNS	_	13	nsubj	_	_
2	between	between	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	5	amod	_	_
5	system	system	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HPA	hpa	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	5	conj	_	_
13	represent	represent	VBP	VBP	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	well-documented	well-documented	JJ	JJ	_	17	amod	_	_
16	biological	biological	JJ	JJ	_	15	dep	_	_
17	phenomenon	phenomenon	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	13	punct	_	_

1	While	while	IN	IN	_	8	mark	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	administration	administration	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	glucocorticoids	glucocorticoid	NNS	NNS	_	4	nmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	inhibit	inhibit	VB	VB	_	35	advcl	_	_
9	concanavalin	concanavalin	NN	NN	_	13	compound	_	_
10	A	a	NN	NN	_	13	compound	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	Con	con	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	8	dobj	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	-	-	:	:	_	13	punct	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	phytohemagglutinin	phytohemagglutinin	NN	NN	_	21	nmod:npmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	PHA	pha	NN	NN	_	21	nmod:npmod	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	-induced	-induced	JJ	JJ	_	13	conj	_	_
22	T-cell	t-cell	NN	NN	_	23	compound	_	_
23	proliferation	proliferation	NN	NN	_	13	dep	_	_
24	,	,	,	,	_	35	punct	_	_
25	pokeweed	pokeweed	NN	NN	_	32	compound	_	_
26	mitogen	mitogen	NN	NN	_	32	compound	_	_
27	(	(	-LRB-	-LRB-	_	32	punct	_	_
28	PWM	pwm	NN	NN	_	32	compound	_	_
29	)	)	-RRB-	-RRB-	_	32	punct	_	_
30	-driven	-driven	JJ	JJ	_	32	amod	_	_
31	B-cell	b-cell	NN	NN	_	32	compound	_	_
32	mitogenesis	mitogenesis	NN	NN	_	35	nsubj	_	_
33	is	be	VBZ	VBZ	_	35	cop	_	_
34	relatively	relatively	RB	RB	_	35	advmod	_	_
35	resistant	resistant	JJ	JJ	_	0	root	_	_
36	to	to	TO	TO	_	37	case	_	_
37	glucocorticoids	glucocorticoid	NNS	NNS	_	35	nmod	_	_
38	.	.	.	.	_	35	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	explore	explore	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	link	link	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	HPA	hpa	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	8	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	relation	relation	NN	NN	_	3	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	dose-response	dose-response	JJ	JJ	_	21	amod	_	_
21	curves	curve	NNS	NNS	_	23	nsubjpass	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	obtained	obtain	VBN	VBN	_	3	parataxis	_	_
24	for	for	IN	IN	_	26	case	_	_
25	Con	con	NN	NN	_	26	compound	_	_
26	A-	a-	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	PHA	pha	JJ	JJ	_	29	amod	_	_
29	-induced	-induced	JJ	JJ	_	26	conj	_	_
30	T-cell	t-cell	NN	NN	_	31	compound	_	_
31	mitogenesis	mitogenesis	NN	NN	_	26	dep	_	_
32	,	,	,	,	_	26	punct	_	_
33	PWM-generated	pwm-generated	JJ	JJ	_	35	amod	_	_
34	B-cell	b-cell	NN	NN	_	35	compound	_	_
35	mitogenesis	mitogenesis	NN	NN	_	26	conj	_	_
36	and	and	CC	CC	_	26	cc	_	_
37	spontaneous	spontaneous	JJ	JJ	_	39	amod	_	_
38	lymphocyte	lymphocyte	NN	NN	_	39	compound	_	_
39	proliferation	proliferation	NN	NN	_	26	conj	_	_
40	in	in	IN	IN	_	43	case	_	_
41	13	13	CD	CD	_	43	nummod	_	_
42	healthy	healthy	JJ	JJ	_	43	amod	_	_
43	controls	control	NNS	NNS	_	26	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	assessed	assess	VBN	VBN	_	0	root	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vivo	vivo	FW	FW	_	4	advmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	depletion	depletion	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	endogenous	endogenous	JJ	JJ	_	11	amod	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	8	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	oral	oral	JJ	JJ	_	14	amod	_	_
14	administration	administration	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	1.5	1.5	CD	CD	_	17	nummod	_	_
17	g	g	NN	NN	_	14	nmod	_	_
18	metyrapone	metyrapone	NN	NN	_	17	dep	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	MET	met	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	subsequent	subsequent	JJ	JJ	_	25	amod	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	25	compound	_	_
25	replacement	replacement	NN	NN	_	8	conj	_	_
26	,	,	,	,	_	8	punct	_	_
27	and	and	CC	CC	_	8	cc	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vitro	vitro	FW	FW	_	8	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	incubation	incubation	NN	NN	_	8	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	different	different	JJ	JJ	_	37	amod	_	_
37	doses	dose	NNS	NNS	_	31	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	dexamethasone	dexamethasone	NN	NN	_	37	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	DEX	dex	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	4	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	decrease	decrease	NN	NN	_	2	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	PWM-induced	pwm-induced	JJ	JJ	_	9	amod	_	_
8	B-cell	b-cell	NN	NN	_	9	compound	_	_
9	mitogenesis	mitogenesis	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	a	a	DT	DT	_	14	det	_	_
12	more	more	RBR	RBR	_	13	advmod	_	_
13	pronounced	pronounced	JJ	JJ	_	14	amod	_	_
14	effect	effect	NN	NN	_	5	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	DEX	dex	NN	NN	_	14	nmod	_	_
17	administered	administer	VBN	VBN	_	16	acl	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	17	advmod	_	_
20	on	on	IN	IN	_	23	case	_	_
21	spontaneous	spontaneous	JJ	JJ	_	23	amod	_	_
22	lymphocyte	lymphocyte	NN	NN	_	23	compound	_	_
23	proliferation	proliferation	NN	NN	_	17	nmod	_	_
24	after	after	IN	IN	_	26	case	_	_
25	MET	met	NN	NN	_	26	compound	_	_
26	treatment	treatment	NN	NN	_	5	nmod	_	_
27	when	when	WRB	WRB	_	28	advmod	_	_
28	compared	compare	VBN	VBN	_	2	advcl	_	_
29	with	with	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	DEX	dex	NN	NN	_	35	compound	_	_
32	plus	plus	CC	CC	_	31	cc	_	_
33	MET	met	NN	NN	_	31	conj	_	_
34	pretreated	pretreated	JJ	JJ	_	35	amod	_	_
35	condition	condition	NN	NN	_	28	nmod	_	_
36	in	in	FW	FW	_	35	amod	_	_
37	vivo	vivo	FW	FW	_	36	dep	_	_
38	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inhibition	inhibition	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	spontaneous	spontaneous	JJ	JJ	_	10	amod	_	_
9	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
10	proliferation	proliferation	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nmod	_	_
13	in	in	FW	FW	_	12	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	related	related	JJ	JJ	_	3	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	function	function	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	14	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	PWM-generated	pwm-generated	JJ	JJ	_	6	amod	_	_
5	B-cell	b-cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	2	nmod	_	_
7	following	follow	VBG	VBG	_	9	case	_	_
8	cortisol	cortisol	NN	NN	_	9	compound	_	_
9	depletion	depletion	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	MET	met	NN	NN	_	9	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	seen	see	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	connection	connection	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	impaired	impaired	JJ	JJ	_	19	amod	_	_
19	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	20	amod	_	_
20	induction	induction	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	interleukin-1	interleukin-1	NN	NN	_	24	compound	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	synthesis	synthesis	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Mineralocorticoids	Mineralocorticoids	NNPS	NNPS	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	mineralocorticoid	mineralocorticoid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	conj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	leukocytes	leukocyte	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	pregnancy-induced	pregnancy-induced	JJ	JJ	_	12	amod	_	_
12	hypertension	hypertension	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	18	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	mineralocorticoids	mineralocorticoid	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pathophysiology	pathophysiology	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	pregnancy-induced	pregnancy-induced	JJ	JJ	_	12	amod	_	_
12	hypertension	hypertension	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PIH	pih	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	studied	study	VBD	VBD	_	0	root	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	aldosterone	aldosterone	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	18-hydroxycorticosterone	18-hydroxycorticosterone	NN	NN	_	20	conj	_	_
23	levels	level	NNS	NNS	_	18	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	25	25	CD	CD	_	26	nummod	_	_
26	women	woman	NNS	NNS	_	23	nmod	_	_
27	with	with	IN	IN	_	28	case	_	_
28	PIH	pih	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	25	25	CD	CD	_	33	nummod	_	_
31	normal	normal	JJ	JJ	_	33	amod	_	_
32	pregnant	pregnant	JJ	JJ	_	33	amod	_	_
33	women	woman	NNS	NNS	_	26	conj	_	_
34	,	,	,	,	_	33	punct	_	_
35	as	as	IN	IN	_	36	case	_	_
36	controls	control	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	18	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	evaluated	evaluate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	11	det	_	_
6	mineralocorticoid	mineralocorticoid	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MR	mr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	status	status	NN	NN	_	4	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	leukocytes	leukocyte	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	2	2	CD	CD	_	18	nummod	_	_
18	groups	group	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	MR	mr	NN	NN	_	2	compound	_	_
2	count	count	NN	NN	_	11	nsubjpass	_	_
3	was	be	VBD	VBD	_	11	auxpass	_	_
4	significantly	significantly	RB	RB	_	11	advmod	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	P	p	NN	NN	_	9	dep	_	_
7	less	less	JJR	JJR	_	9	advmod	_	_
8	than	than	IN	IN	_	7	mwe	_	_
9	0.0005	0.0005	CD	CD	_	11	parataxis	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	decreased	decrease	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	PIH	pih	NN	NN	_	15	compound	_	_
15	group	group	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	21	punct	_	_
17	148	148	CD	CD	_	21	nummod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	9	9	CD	CD	_	17	conj	_	_
20	binding	bind	VBG	VBG	_	21	amod	_	_
21	sites/cell	sites/cell	NNS	NNS	_	15	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	compared	compare	VBN	VBN	_	27	case	_	_
24	with	with	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	control	control	NN	NN	_	27	compound	_	_
27	group	group	NN	NN	_	11	advcl	_	_
28	(	(	-LRB-	-LRB-	_	33	punct	_	_
29	300	300	CD	CD	_	33	nummod	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	17	17	CD	CD	_	29	conj	_	_
32	binding	bind	VBG	VBG	_	33	amod	_	_
33	sites/cell	sites/cell	NNS	NNS	_	27	dep	_	_
34	;	;	:	:	_	33	punct	_	_
35	mean	mean	NN	NN	_	33	dep	_	_
36	+/-	+/-	CC	CC	_	35	cc	_	_
37	SEM	sem	NN	NN	_	35	conj	_	_
38	)	)	-RRB-	-RRB-	_	33	punct	_	_
39	.	.	.	.	_	11	punct	_	_

1	Plasma	plasma	NN	NN	_	2	compound	_	_
2	aldosterone	aldosterone	NN	NN	_	11	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	women	woman	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PIH	pih	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	11	cop	_	_
8	281	281	CD	CD	_	11	nummod	_	_
9	+/-	+/-	CC	CC	_	8	cc	_	_
10	61	61	CD	CD	_	8	conj	_	_
11	pmol/L	pmol/l	NN	NN	_	0	root	_	_
12	;	;	:	:	_	11	punct	_	_
13	in	in	IN	IN	_	16	case	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	pregnant	pregnant	JJ	JJ	_	16	amod	_	_
16	women	woman	NNS	NNS	_	22	nmod	_	_
17	it	it	PRP	PRP	_	22	nsubj	_	_
18	was	be	VBD	VBD	_	22	cop	_	_
19	697	697	CD	CD	_	22	nummod	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	172	172	CD	CD	_	19	conj	_	_
22	pmol/L	pmol/l	NN	NN	_	11	parataxis	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	P	p	NN	NN	_	27	dep	_	_
25	less	less	JJR	JJR	_	27	advmod	_	_
26	than	than	IN	IN	_	25	mwe	_	_
27	0.025	0.025	CD	CD	_	22	parataxis	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	22	punct	_	_

1	Plasma	plasma	NN	NN	_	2	compound	_	_
2	18-hydroxycorticosterone	18-hydroxycorticosterone	NN	NN	_	12	nsubj	_	_
3	was	be	VBD	VBD	_	12	cop	_	_
4	also	also	RB	RB	_	12	advmod	_	_
5	significantly	significantly	RB	RB	_	12	advmod	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	P	p	NN	NN	_	10	dep	_	_
8	less	less	JJR	JJR	_	10	advmod	_	_
9	than	than	IN	IN	_	8	mwe	_	_
10	0.025	0.025	CD	CD	_	12	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	lower	lower	JJR	JJR	_	0	root	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PIH	pih	NN	NN	_	12	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	1071	1071	CD	CD	_	19	nummod	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	149	149	CD	CD	_	16	conj	_	_
19	pmol/L	pmol/l	NN	NN	_	14	appos	_	_
20	;	;	:	:	_	14	punct	_	_
21	controls	control	NNS	NNS	_	14	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	1907	1907	CD	CD	_	26	nummod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	318	318	CD	CD	_	23	conj	_	_
26	pmol/L	pmol/l	NN	NN	_	21	appos	_	_
27	)	)	-RRB-	-RRB-	_	14	punct	_	_
28	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	values	value	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	at	at	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	onset	onset	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	clinical	clinical	JJ	JJ	_	10	amod	_	_
10	symptoms	symptom	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	PIH	pih	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	6	nsubjpass	_	_
3	can	can	MD	MD	_	6	aux	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	explained	explain	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	down-regulation	down-regulation	NN	NN	_	6	nmod	_	_
10	due	due	JJ	JJ	_	13	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	higher	higher	JJR	JJR	_	13	amod	_	_
13	levels	level	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	mineralocorticoids	mineralocorticoid	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	PIH	pih	NN	NN	_	15	nmod	_	_
18	;	;	:	:	_	6	punct	_	_
19	a	a	DT	DT	_	22	det	_	_
20	hitherto	hitherto	RB	RB	_	21	advmod	_	_
21	unknown	unknown	JJ	JJ	_	22	amod	_	_
22	mineralocorticoid	mineralocorticoid	NN	NN	_	28	nsubj	_	_
23	may	may	MD	MD	_	28	aux	_	_
24	,	,	,	,	_	28	punct	_	_
25	thus	thus	RB	RB	_	28	advmod	_	_
26	,	,	,	,	_	28	punct	_	_
27	be	be	VB	VB	_	28	cop	_	_
28	responsible	responsible	JJ	JJ	_	6	parataxis	_	_
29	for	for	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	hypertension	hypertension	NN	NN	_	35	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	altered	altered	JJ	JJ	_	34	amod	_	_
34	MR	mr	NN	NN	_	31	conj	_	_
35	status	status	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	28	punct	_	_

1	Mineralocorticoid	mineralocorticoid	NN	NN	_	3	compound	_	_
2	effector	effector	NN	NN	_	3	compound	_	_
3	mechanism	mechanism	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	preeclampsia	preeclampsia	NN	NN	_	3	nmod	_	_
6	.	.	.	.	_	3	punct	_	_

1	Mineralocorticoid	mineralocorticoid	NN	NN	_	3	compound	_	_
2	effector	effector	NN	NN	_	3	compound	_	_
3	mechanisms	mechanism	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	evaluated	evaluate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	29	29	CD	CD	_	8	nummod	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	preeclampsia	preeclampsia	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	in	in	IN	IN	_	15	case	_	_
13	25	25	CD	CD	_	15	nummod	_	_
14	uncomplicated	uncomplicated	JJ	JJ	_	15	amod	_	_
15	pregnancies	pregnancy	NNS	NNS	_	8	conj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	measurement	measurement	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	aldosterone	aldosterone	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	levels	level	NNS	NNS	_	20	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	mineralocorticoid	mineralocorticoid	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	MR	mr	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	31	case	_	_
30	mononuclear	mononuclear	JJ	JJ	_	31	amod	_	_
31	leucocytes	leucocyte	NNS	NNS	_	25	nmod	_	_
32	,	,	,	,	_	20	punct	_	_
33	and	and	CC	CC	_	20	cc	_	_
34	subtraction	subtraction	NN	NN	_	36	compound	_	_
35	potential	potential	NN	NN	_	36	compound	_	_
36	difference	difference	NN	NN	_	20	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	SPD	spd	NN	NN	_	36	appos	_	_
39	;	;	:	:	_	38	punct	_	_
40	rectal	rectal	JJ	JJ	_	43	amod	_	_
41	minus	minus	CC	CC	_	40	cc	_	_
42	oral	oral	JJ	JJ	_	40	conj	_	_
43	values	value	NNS	NNS	_	38	dep	_	_
44	)	)	-RRB-	-RRB-	_	38	punct	_	_
45	.	.	.	.	_	5	punct	_	_

1	Mean	mean	NN	NN	_	2	compound	_	_
2	values	value	NNS	NNS	_	8	nsubj	_	_
3	for	for	IN	IN	_	5	case	_	_
4	plasma	plasma	NN	NN	_	5	compound	_	_
5	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	8	cop	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	different	different	JJ	JJ	_	0	root	_	_
9	between	between	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	groups	group	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	but	but	CC	CC	_	8	cc	_	_
15	significant	significant	JJ	JJ	_	16	amod	_	_
16	differences	difference	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	observed	observe	VBN	VBN	_	8	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	MR	mr	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	preeclampsia	preeclampsia	NN	NN	_	20	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	81	81	CD	CD	_	27	nummod	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	44	44	CD	CD	_	24	conj	_	_
27	receptors/cell	receptors/cell	NNS	NNS	_	22	appos	_	_
28	;	;	:	:	_	22	punct	_	_
29	controls	control	NNS	NNS	_	22	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	306	306	CD	CD	_	29	appos	_	_
32	+/-	+/-	CC	CC	_	31	cc	_	_
33	168	168	CD	CD	_	31	conj	_	_
34	)	)	-RRB-	-RRB-	_	22	punct	_	_
35	and	and	CC	CC	_	20	cc	_	_
36	SPD	spd	NN	NN	_	20	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	preeclampsia	preeclampsia	NN	NN	_	36	dep	_	_
39	,	,	,	,	_	38	punct	_	_
40	65	65	CD	CD	_	43	nummod	_	_
41	+/-	+/-	CC	CC	_	40	cc	_	_
42	7	7	CD	CD	_	40	conj	_	_
43	mV	mv	NN	NN	_	38	appos	_	_
44	;	;	:	:	_	38	punct	_	_
45	controls	control	NNS	NNS	_	38	dep	_	_
46	,	,	,	,	_	45	punct	_	_
47	12	12	CD	CD	_	50	nummod	_	_
48	+/-	+/-	CC	CC	_	47	cc	_	_
49	5	5	CD	CD	_	47	conj	_	_
50	mV	mv	NN	NN	_	45	appos	_	_
51	)	)	-RRB-	-RRB-	_	38	punct	_	_
52	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	six	six	CD	CD	_	3	nummod	_	_
3	cases	case	NNS	NNS	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	determined	determine	VBD	VBD	_	0	root	_	_
6	MR	mr	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	plasma	plasma	NN	NN	_	9	compound	_	_
9	aldosterone	aldosterone	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	SPD	spd	NN	NN	_	6	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	6	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	preeclampsia	preeclampsia	NN	NN	_	14	nmod	_	_
17	before	before	IN	IN	_	22	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	3	3	CD	CD	_	20	nummod	_	_
20	months	month	NNS	NNS	_	17	conj	_	_
21	after	after	IN	IN	_	20	case	_	_
22	delivery	delivery	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	MR	mr	NNS	NNS	_	3	nsubj	_	_
2	were	be	VBD	VBD	_	3	aux	_	_
3	reduced	reduce	VBN	VBN	_	0	root	_	_
4	before	before	IN	IN	_	5	case	_	_
5	delivery	delivery	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	96	96	CD	CD	_	10	nummod	_	_
8	+/-	+/-	CC	CC	_	7	cc	_	_
9	27	27	CD	CD	_	7	conj	_	_
10	receptors/cell	receptors/cell	NNS	NNS	_	3	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	SPD	spd	NN	NN	_	15	nsubj	_	_
15	increased	increase	VBD	VBD	_	3	conj	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	64	64	CD	CD	_	20	nummod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	8	8	CD	CD	_	17	conj	_	_
20	mV	mv	NN	NN	_	15	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	3	punct	_	_
23	with	with	IN	IN	_	26	mark	_	_
24	both	both	DT	DT	_	25	det	_	_
25	parameters	parameter	NNS	NNS	_	26	nsubj	_	_
26	normalizing	normalize	VBG	VBG	_	3	advcl	_	_
27	after	after	IN	IN	_	28	case	_	_
28	delivery	delivery	NN	NN	_	26	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	MR	mr	NN	NN	_	26	dep	_	_
31	,	,	,	,	_	30	punct	_	_
32	242	242	CD	CD	_	30	appos	_	_
33	+/-	+/-	CC	CC	_	32	cc	_	_
34	79	79	CD	CD	_	32	conj	_	_
35	;	;	:	:	_	30	punct	_	_
36	SPD	spd	NN	NN	_	30	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	14.0	14.0	CD	CD	_	41	nummod	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	4	4	CD	CD	_	38	conj	_	_
41	mV	mv	NN	NN	_	36	appos	_	_
42	)	)	-RRB-	-RRB-	_	30	punct	_	_
43	.	.	.	.	_	3	punct	_	_

1	Aldosterone	aldosterone	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	3	nsubj	_	_
3	returned	return	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	normal	normal	JJ	JJ	_	7	amod	_	_
6	nonpregnant	nonpregnant	JJ	JJ	_	7	amod	_	_
7	values	value	NNS	NNS	_	3	nmod	_	_
8	after	after	IN	IN	_	9	case	_	_
9	delivery	delivery	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	abnormalities	abnormality	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	mineralocorticoid	mineralocorticoid	NN	NN	_	12	compound	_	_
11	effector	effector	NN	NN	_	12	compound	_	_
12	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	etiology	etiology	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	preeclampsia	preeclampsia	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	could	could	MD	MD	_	23	aux	_	_
20	be	be	VB	VB	_	23	cop	_	_
21	an	a	DT	DT	_	23	det	_	_
22	useful	useful	JJ	JJ	_	23	amod	_	_
23	marker	marker	NN	NN	_	3	conj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	diagnosis	diagnosis	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
3	cell-specific	cell-specific	JJ	JJ	_	5	amod	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	10	nsubj	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	c-Rel-like	c-rel-like	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	6	dobj	_	_
9	preferentially	preferentially	RB	RB	_	10	advmod	_	_
10	interacts	interact	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	15	case	_	_
12	interleukin-6	interleukin-6	NN	NN	_	14	nmod:npmod	_	_
13	kappa	kappa	NN	NN	_	14	nmod:npmod	_	_
14	B-related	b-related	JJ	JJ	_	15	amod	_	_
15	motifs	motif	NNS	NNS	_	10	nmod	_	_
16	whose	whose	WP$	WP$	_	17	nmod:poss	_	_
17	activities	activity	NNS	NNS	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	repressed	repress	VBN	VBN	_	15	acl:relcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proto-oncoprotein	proto-oncoprotein	NN	NN	_	3	compound	_	_
3	c-Rel	c-rel	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	member	member	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
10	factor	factor	NN	NN	_	15	compound	_	_
11	kappa	kappa	NN	NN	_	15	compound	_	_
12	B	b	NN	NN	_	15	compound	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	6	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	includes	include	VBZ	VBZ	_	15	acl:relcl	_	_
19	the	the	DT	DT	_	23	det	_	_
20	p50	p50	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	p65	p65	NN	NN	_	20	conj	_	_
23	subunits	subunit	NNS	NNS	_	18	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
26	factor	factor	NN	NN	_	28	compound	_	_
27	kappa	kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	c-Rel	c-rel	NN	NN	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
7	to	to	TO	TO	_	10	case	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	6	nmod	_	_
11	as	as	IN	IN	_	12	case	_	_
12	homodimers	homodimer	NNS	NNS	_	6	nmod	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	heterodimers	heterodimer	NNS	NNS	_	12	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	p50	p50	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	homodimers	homodimer	NNS	NNS	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	heterodimers	heterodimer	NNS	NNS	_	2	conj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	distinct	distinct	JJ	JJ	_	8	amod	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	specificities	specificity	NNS	NNS	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	affinities	affinity	NNS	NNS	_	8	conj	_	_
11	for	for	IN	IN	_	15	case	_	_
12	various	various	JJ	JJ	_	15	amod	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	c-Rel	c-rel	NN	NN	_	6	compound	_	_
6	homodimer	homodimer	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	affinity	affinity	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	21	case	_	_
12	interleukin-6	interleukin-6	NN	NN	_	21	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IL-6	il-6	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	beta	beta	NN	NN	_	20	compound	_	_
18	interferon	interferon	NN	NN	_	20	compound	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	12	conj	_	_
21	sites	site	NNS	NNS	_	10	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	spite	spite	NN	NN	_	5	dep	_	_
3	of	of	IN	IN	_	5	case	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	association	association	NN	NN	_	14	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	p50	p50	NN	NN	_	5	nmod	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	5	advmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	however	however	RB	RB	_	14	advmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	found	find	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	19	det	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	14	dobj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	14	advmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	contains	contain	VBZ	VBZ	_	14	dep	_	_
24	c-Rel	c-rel	NN	NN	_	28	compound	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	24	cc	_	_
27	p50	p50	NN	NN	_	24	conj	_	_
28	epitopes	epitope	NNS	NNS	_	23	dobj	_	_
29	;	;	:	:	_	14	punct	_	_
30	this	this	DT	DT	_	31	det	_	_
31	factor	factor	NN	NN	_	41	nsubj	_	_
32	,	,	,	,	_	31	punct	_	_
33	termed	term	VBN	VBN	_	31	acl	_	_
34	IL-6	il-6	NN	NN	_	38	compound	_	_
35	kappa	kappa	NN	NN	_	38	compound	_	_
36	B	b	NN	NN	_	38	compound	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	factor	factor	NN	NN	_	33	xcomp	_	_
39	II	ii	CD	CD	_	38	nummod	_	_
40	,	,	,	,	_	31	punct	_	_
41	appears	appear	VBZ	VBZ	_	14	parataxis	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	contain	contain	VB	VB	_	41	xcomp	_	_
44	the	the	DT	DT	_	46	det	_	_
45	c-Rel	c-rel	NN	NN	_	46	compound	_	_
46	homodimer	homodimer	NN	NN	_	43	dobj	_	_
47	and	and	CC	CC	_	41	cc	_	_
48	preferentially	preferentially	RB	RB	_	49	advmod	_	_
49	recognizes	recognize	VBZ	VBZ	_	41	conj	_	_
50	several	several	JJ	JJ	_	56	amod	_	_
51	IL-6	il-6	NN	NN	_	53	nmod:npmod	_	_
52	kappa	kappa	NN	NN	_	53	nmod:npmod	_	_
53	B-related	b-related	JJ	JJ	_	56	amod	_	_
54	kappa	kappa	NN	NN	_	56	compound	_	_
55	B	b	NN	NN	_	56	compound	_	_
56	motifs	motif	NNS	NNS	_	49	dobj	_	_
57	.	.	.	.	_	41	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	it	it	PRP	PRP	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	been	be	VBN	VBN	_	6	auxpass	_	_
5	previously	previously	RB	RB	_	6	advmod	_	_
6	shown	show	VBN	VBN	_	28	advcl	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	12	det	_	_
9	IL-6	il-6	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	motif	motif	NN	NN	_	13	nsubj	_	_
13	functions	function	VBZ	VBZ	_	6	ccomp	_	_
14	as	as	IN	IN	_	20	case	_	_
15	a	a	DT	DT	_	20	det	_	_
16	potent	potent	JJ	JJ	_	20	amod	_	_
17	IL-1/tumor	il-1/tumor	NN	NN	_	19	nmod:npmod	_	_
18	necrosis	necrosis	NN	NN	_	19	nmod:npmod	_	_
19	factor-responsive	factor-responsive	JJ	JJ	_	20	amod	_	_
20	element	element	NN	NN	_	13	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	nonlymphoid	nonlymphoid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	13	nmod	_	_
24	,	,	,	,	_	28	punct	_	_
25	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
26	activity	activity	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	found	find	VBN	VBN	_	0	root	_	_
29	to	to	TO	TO	_	31	mark	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	repressed	repress	VBN	VBN	_	28	xcomp	_	_
32	in	in	IN	IN	_	34	case	_	_
33	lymphoid	lymphoid	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	such	such	JJ	JJ	_	40	case	_	_
36	as	as	IN	IN	_	35	mwe	_	_
37	a	a	DT	DT	_	40	det	_	_
38	Jurkat	jurkat	NN	NN	_	40	compound	_	_
39	T-cell	t-cell	NN	NN	_	40	compound	_	_
40	line	line	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	28	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	present	present	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	IL-6	il-6	NN	NN	_	10	compound	_	_
7	kappa	kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	12	nsubj	_	_
11	II	ii	CD	CD	_	10	nummod	_	_
12	functions	function	VBZ	VBZ	_	4	ccomp	_	_
13	as	as	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	repressor	repressor	NN	NN	_	12	nmod	_	_
16	specific	specific	JJ	JJ	_	15	amod	_	_
17	for	for	IN	IN	_	23	case	_	_
18	IL-6	il-6	NN	NN	_	20	nmod:npmod	_	_
19	kappa	kappa	NN	NN	_	20	nmod:npmod	_	_
20	B-related	b-related	JJ	JJ	_	23	amod	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	motifs	motif	NNS	NNS	_	16	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	12	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	normal	normal	JJ	JJ	_	5	amod	_	_
4	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	14	case	_	_
7	the	the	DT	DT	_	14	det	_	_
8	endogenous	endogenous	JJ	JJ	_	10	amod	_	_
9	thyroid	thyroid	NN	NN	_	10	compound	_	_
10	hormone	hormone	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
13	acid	acid	NN	NN	_	10	conj	_	_
14	receptors	receptor	NNS	NNS	_	1	nmod	_	_
15	:	:	:	:	_	1	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	possible	possible	JJ	JJ	_	18	amod	_	_
18	target	target	NN	NN	_	1	dep	_	_
19	for	for	IN	IN	_	22	case	_	_
20	v-erbA	v-erba	NN	NN	_	22	compound	_	_
21	oncogene	oncogene	NN	NN	_	22	compound	_	_
22	action	action	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	v-erbA	v-erba	NN	NN	_	3	compound	_	_
3	oncogene	oncogene	NN	NN	_	18	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	mutated	mutate	VBN	VBN	_	7	amod	_	_
7	version	version	NN	NN	_	3	appos	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	thyroid	thyroid	NN	NN	_	13	compound	_	_
11	hormone	hormone	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	c-erbA/TR-alpha	c-erba/tr-alpha	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	3	punct	_	_
18	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
19	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	constitutively	constitutively	RB	RB	_	23	advmod	_	_
23	represses	repress	VBZ	VBZ	_	18	conj	_	_
24	transcription	transcription	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	certain	certain	JJ	JJ	_	28	amod	_	_
27	erythrocyte	erythrocyte	NN	NN	_	28	compound	_	_
28	genes	gene	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	18	punct	_	_
30	suggesting	suggest	VBG	VBG	_	18	advcl	_	_
31	a	a	DT	DT	_	33	det	_	_
32	normal	normal	JJ	JJ	_	33	amod	_	_
33	function	function	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	proto-oncogene	proto-oncogene	NN	NN	_	37	compound	_	_
37	c-erbA	c-erba	NN	NN	_	33	nmod	_	_
38	in	in	IN	IN	_	39	case	_	_
39	erythropoiesis	erythropoiesis	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	18	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	endogenous	endogenous	JJ	JJ	_	10	amod	_	_
7	thyroid	thyroid	NN	NN	_	10	compound	_	_
8	hormone	hormone	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	25	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	c-erbA/TR-alpha	c-erba/tr-alpha	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	the	the	DT	DT	_	21	det	_	_
16	closely	closely	RB	RB	_	17	advmod	_	_
17	related	related	JJ	JJ	_	21	amod	_	_
18	retinoic	retinoic	JJ	JJ	_	21	amod	_	_
19	acid	acid	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	10	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RAR-alpha	rar-alpha	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	play	play	VBP	VBP	_	3	ccomp	_	_
26	a	a	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	regulation	regulation	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	normal	normal	JJ	JJ	_	34	amod	_	_
33	erythroid	erythroid	JJ	JJ	_	34	amod	_	_
34	differentiation	differentiation	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	distinctly	distinctly	RB	RB	_	7	advmod	_	_
7	modulated	modulate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
10	differentiation	differentiation	NN	NN	_	11	compound	_	_
11	program	program	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	erythroblasts	erythroblast	NNS	NNS	_	15	conj	_	_
18	reversibly	reversibly	RB	RB	_	19	advmod	_	_
19	transformed	transform	VBN	VBN	_	15	acl	_	_
20	by	by	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	conditional	conditional	JJ	JJ	_	25	amod	_	_
23	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	oncogene	oncogene	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	added	add	VBN	VBN	_	10	advcl	_	_
3	pulsewise	pulsewise	RB	RB	_	2	advmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	immature	immature	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	differentiation	differentiation	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	accelerated	accelerate	VBN	VBN	_	0	root	_	_
11	while	while	IN	IN	_	15	mark	_	_
12	more	more	RBR	RBR	_	13	advmod	_	_
13	mature	mature	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	15	nsubj	_	_
15	underwent	undergo	VBD	VBD	_	10	advcl	_	_
16	premature	premature	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	death	death	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	Thyroid	thyroid	NN	NN	_	2	compound	_	_
2	hormone	hormone	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	T3	t3	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	alone	alone	RB	RB	_	2	advmod	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	similar	similar	JJ	JJ	_	11	amod	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	weaker	weaker	JJR	JJR	_	8	conj	_	_
11	effects	effect	NNS	NNS	_	7	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Interestingly	interestingly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	T3	t3	NN	NN	_	5	nsubj	_	_
4	strongly	strongly	RB	RB	_	5	advmod	_	_
5	enhanced	enhance	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	action	action	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	RA	ra	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
12	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
13	action	action	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	two	two	CD	CD	_	17	nummod	_	_
17	receptors	receptor	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	modulating	modulate	VBG	VBG	_	13	acl	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	RAR-alpha	rar-alpha	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	receptor-negative	receptor-negative	JJ	JJ	_	8	amod	_	_
8	erythroblasts	erythroblast	NNS	NNS	_	1	nmod	_	_
9	conferred	confer	VBD	VBD	_	0	root	_	_
10	RA-induced	ra-induced	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	differentiation	differentiation	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	otherwise	otherwise	RB	RB	_	17	advmod	_	_
17	unresponsive	unresponsive	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	9	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	thus	thus	RB	RB	_	9	advmod	_	_
21	showing	show	VBG	VBG	_	9	xcomp	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	RAR-alpha	rar-alpha	NN	NN	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	essential	essential	JJ	JJ	_	21	ccomp	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	RA	ra	NN	NN	_	30	compound	_	_
30	effect	effect	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Likewise	likewise	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	enhanced	enhance	VBN	VBN	_	4	amod	_	_
4	expression	expression	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	exogenous	exogenous	JJ	JJ	_	7	amod	_	_
7	c-erbA/TR-alpha	c-erba/tr-alpha	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	erythroblasts	erythroblast	NNS	NNS	_	4	nmod	_	_
10	rendered	render	VBD	VBD	_	0	root	_	_
11	them	they	PRP	PRP	_	12	nsubj	_	_
12	susceptible	susceptible	JJ	JJ	_	10	xcomp	_	_
13	to	to	TO	TO	_	14	case	_	_
14	modulation	modulation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	differentiation	differentiation	NN	NN	_	14	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	T3	t3	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	similar	similar	JJ	JJ	_	23	amod	_	_
23	function	function	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	both	both	DT	DT	_	26	det	_	_
26	receptors	receptor	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Leukotriene	leukotriene	NN	NN	_	2	compound	_	_
2	B4	b4	NN	NN	_	3	nsubj	_	_
3	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
4	c-fos	c-fos	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	3	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-1	ap-1	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	leukotriene	leukotriene	NN	NN	_	8	compound	_	_
8	B4	b4	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LTB4	ltb4	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	a	a	DT	DT	_	17	det	_	_
14	potent	potent	JJ	JJ	_	17	amod	_	_
15	lipid	lipid	NN	NN	_	17	compound	_	_
16	proinflammatory	proinflammatory	JJ	JJ	_	17	amod	_	_
17	mediator	mediator	NN	NN	_	8	appos	_	_
18	,	,	,	,	_	8	punct	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	5	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	proto-oncogenes	proto-oncogene	NNS	NNS	_	21	nmod	_	_
25	c-jun	c-jun	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	c-fos	c-fos	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	looked	look	VBD	VBD	_	0	root	_	_
6	at	at	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	modulation	modulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factors	factor	NNS	NNS	_	8	nmod	_	_
12	binding	bind	VBG	VBG	_	11	acl	_	_
13	specifically	specifically	RB	RB	_	17	advmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	AP-1	ap-1	NN	NN	_	17	compound	_	_
17	element	element	NN	NN	_	12	nmod	_	_
18	after	after	IN	IN	_	20	case	_	_
19	LTB4	ltb4	NN	NN	_	20	compound	_	_
20	stimulation	stimulation	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	LTB4	ltb4	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	time-	time-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	concentration-dependent	concentration-dependent	JJ	JJ	_	11	conj	_	_
14	manner	manner	NN	NN	_	2	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	c-jun	c-jun	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	21	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	3	acl:relcl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	peripheral-blood	peripheral-blood	NN	NN	_	12	compound	_	_
12	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	relatively	relatively	RB	RB	_	15	advmod	_	_
15	high	high	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	8	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	was	be	VBD	VBD	_	21	aux	_	_
19	also	also	RB	RB	_	21	advmod	_	_
20	slightly	slightly	RB	RB	_	21	advmod	_	_
21	augmented	augmented	JJ	JJ	_	0	root	_	_
22	by	by	IN	IN	_	23	case	_	_
23	LTB4	ltb4	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	although	although	IN	IN	_	30	mark	_	_
26	to	to	TO	TO	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	much	much	RB	RB	_	29	advmod	_	_
29	lower	lower	JJR	JJR	_	30	amod	_	_
30	extent	extent	NN	NN	_	21	advcl	_	_
31	than	than	IN	IN	_	32	case	_	_
32	c-fos	c-fos	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	expression	expression	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	genes	gene	NNS	NNS	_	4	nmod	_	_
9	were	be	VBD	VBD	_	12	cop	_	_
10	also	also	RB	RB	_	12	advmod	_	_
11	slightly	slightly	RB	RB	_	12	advmod	_	_
12	different	different	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	with	with	IN	IN	_	17	mark	_	_
15	c-fos	c-fos	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	17	nsubj	_	_
17	reaching	reach	VBG	VBG	_	12	advcl	_	_
18	a	a	DT	DT	_	19	det	_	_
19	peak	peak	NN	NN	_	17	dobj	_	_
20	at	at	IN	IN	_	22	case	_	_
21	15	15	CD	CD	_	22	nummod	_	_
22	min	min	NN	NN	_	17	nmod	_	_
23	after	after	IN	IN	_	24	case	_	_
24	stimulation	stimulation	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	c-jun	c-jun	NN	NN	_	17	conj	_	_
27	at	at	IN	IN	_	29	case	_	_
28	30	30	CD	CD	_	29	nummod	_	_
29	min	min	NN	NN	_	26	dep	_	_
30	.	.	.	.	_	12	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	messages	message	NNS	NNS	_	4	nsubj	_	_
3	rapidly	rapidly	RB	RB	_	4	advmod	_	_
4	declined	decline	VBD	VBD	_	0	root	_	_
5	thereafter	thereafter	RB	RB	_	4	advmod	_	_
6	.	.	.	.	_	4	punct	_	_

1	Stability	stability	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	c-fos	c-fos	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	mRNA	mrna	NN	NN	_	1	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affected	affect	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	LTB4	ltb4	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	assessed	assess	VBN	VBN	_	10	advcl	_	_
16	after	after	IN	IN	_	19	case	_	_
17	actinomycin	actinomycin	NN	NN	_	19	compound	_	_
18	D	d	NN	NN	_	19	compound	_	_
19	treatment	treatment	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	6	nsubj	_	_
4	in	in	FW	FW	_	5	compound	_	_
5	vitro	vitro	FW	FW	_	3	advmod	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	LTB4	ltb4	NN	NN	_	9	nsubj	_	_
9	increased	increase	VBD	VBD	_	6	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	c-fos	c-fos	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	7-fold	7-fold	RB	RB	_	9	advmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	c-jun	c-jun	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	9	conj	_	_
21	1.4-fold	1.4-fold	RB	RB	_	20	advmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Resting	rest	VBG	VBG	_	2	amod	_	_
2	monocytes	monocyte	NNS	NNS	_	3	nsubj	_	_
3	contained	contain	VBD	VBD	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	3	dobj	_	_
6	binding	bind	VBG	VBG	_	5	acl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	but	but	CC	CC	_	3	cc	_	_
13	stimulation	stimulation	NN	NN	_	18	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	LTB4	ltb4	NN	NN	_	13	nmod	_	_
18	induced	induce	VBD	VBD	_	3	conj	_	_
19	greater	greater	JJR	JJR	_	21	amod	_	_
20	AP-1-binding	ap-1-binding	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	proteins	protein	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	LTB4	ltb4	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	regulate	regulate	VB	VB	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	modulating	modulate	VBG	VBG	_	7	advcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	yield	yield	NN	NN	_	14	dobj	_	_
17	and/or	and/or	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	function	function	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	16	nmod	_	_
23	such	such	JJ	JJ	_	27	case	_	_
24	as	as	IN	IN	_	23	mwe	_	_
25	AP-1-binding	ap-1-binding	JJ	JJ	_	27	amod	_	_
26	proto-oncogene	proto-oncogene	NN	NN	_	27	compound	_	_
27	products	product	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	11-base-pair	11-base-pair	JJ	JJ	_	5	amod	_	_
3	DNA	dna	NN	NN	_	5	compound	_	_
4	sequence	sequence	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	14	nsubj	_	_
6	apparently	apparently	RB	RB	_	7	advmod	_	_
7	unique	unique	JJ	JJ	_	5	amod	_	_
8	to	to	TO	TO	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	interleukin	interleukin	NN	NN	_	13	compound	_	_
12	4	4	CD	CD	_	13	nummod	_	_
13	gene	gene	NN	NN	_	7	nmod	_	_
14	confers	confer	VBZ	VBZ	_	0	root	_	_
15	responsiveness	responsiveness	NN	NN	_	14	dobj	_	_
16	to	to	TO	TO	_	19	case	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	activation	activation	NN	NN	_	19	compound	_	_
19	signals	signal	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	segment	segment	NN	NN	_	3	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	confers	confer	VBZ	VBZ	_	6	acl:relcl	_	_
9	responsiveness	responsiveness	NN	NN	_	8	dobj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	antigen	antigen	NN	NN	_	13	compound	_	_
12	stimulation	stimulation	NN	NN	_	13	compound	_	_
13	signals	signal	NNS	NNS	_	9	nmod	_	_
14	on	on	IN	IN	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	human	human	JJ	JJ	_	22	amod	_	_
17	interleukin	interleukin	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	IL	il	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	4	4	CD	CD	_	22	nummod	_	_
22	gene	gene	NN	NN	_	8	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	Jurkat	jurkat	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	IL-4	il-4	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	11	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	of	of	IN	IN	_	8	case	_	_
7	10	10	CD	CD	_	8	nummod	_	_
8	kilobases	kilobase	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	composed	compose	VBN	VBN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	four	four	CD	CD	_	14	nummod	_	_
14	exons	exon	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	three	three	CD	CD	_	17	nummod	_	_
17	introns	intron	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	cis-acting	cis-acting	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	8	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	P	p	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	resides	reside	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	5'	5'	JJ	JJ	_	12	nmod:npmod	_	_
12	upstream	upstream	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	8	nmod	_	_
14	;	;	:	:	_	8	punct	_	_
15	no	no	DT	DT	_	18	neg	_	_
16	additional	additional	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	segments	segment	NNS	NNS	_	23	nsubjpass	_	_
19	with	with	IN	IN	_	21	case	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	18	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	identified	identify	VBN	VBN	_	8	parataxis	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	IL-4	il-4	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	23	punct	_	_

1	For	for	IN	IN	_	4	case	_	_
2	further	further	JJ	JJ	_	4	amod	_	_
3	mapping	mapping	NN	NN	_	4	compound	_	_
4	purposes	purpose	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	fusion	fusion	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	constructed	construct	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	14	amod	_	_
14	colony-stimulating	colony-stimulating	JJ	JJ	_	17	amod	_	_
15	factor	factor	NN	NN	_	17	compound	_	_
16	basic	basic	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	10	nmod	_	_
18	containing	contain	VBG	VBG	_	17	acl	_	_
19	60	60	CD	CD	_	21	nummod	_	_
20	base	base	NN	NN	_	21	compound	_	_
21	pairs	pair	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	sequence	sequence	NN	NN	_	21	nmod	_	_
24	upstream	upstream	JJ	JJ	_	21	amod	_	_
25	from	from	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	cap	cap	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	mouse	mouse	NN	NN	_	35	compound	_	_
32	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	33	amod	_	_
33	colony-stimulating	colony-stimulating	JJ	JJ	_	35	amod	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	28	nmod	_	_
36	and	and	CC	CC	_	21	cc	_	_
37	various	various	JJ	JJ	_	38	amod	_	_
38	lengths	length	NNS	NNS	_	21	conj	_	_
39	of	of	IN	IN	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	5'	5'	JJ	JJ	_	42	nmod:npmod	_	_
42	upstream	upstream	JJ	JJ	_	43	amod	_	_
43	sequence	sequence	NN	NN	_	38	nmod	_	_
44	of	of	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	IL-4	il-4	NN	NN	_	47	compound	_	_
47	gene	gene	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	P	p	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	located	located	JJ	JJ	_	0	root	_	_
6	between	between	IN	IN	_	7	case	_	_
7	positions	position	NNS	NNS	_	5	nmod	_	_
8	-79	-79	CD	CD	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	-69	-69	CD	CD	_	8	conj	_	_
11	relative	relative	JJ	JJ	_	16	case	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	start	start	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	5	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	IL-4	il-4	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	5	punct	_	_
23	and	and	CC	CC	_	5	cc	_	_
24	this	this	DT	DT	_	25	det	_	_
25	location	location	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	confirmed	confirm	VBN	VBN	_	5	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	base-substitution	base-substitution	NN	NN	_	30	compound	_	_
30	mutations	mutation	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	plasmids	plasmid	NNS	NNS	_	10	nsubj	_	_
3	carrying	carry	VBG	VBG	_	2	acl	_	_
4	multiple	multiple	JJ	JJ	_	5	amod	_	_
5	copies	copy	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	P	p	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	5	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	higher	higher	JJR	JJR	_	12	amod	_	_
12	responsiveness	responsiveness	NN	NN	_	10	dobj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	stimulation	stimulation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	binding	bind	VBG	VBG	_	5	amod	_	_
3	protein	protein	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	s	s	NNS	NNS	_	17	nsubjpass	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	recognize	recognize	VBP	VBP	_	5	acl:relcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	P	p	NN	NN	_	11	compound	_	_
11	sequence	sequence	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-4	il-4	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	identified	identify	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	20	case	_	_
19	DNA-mobility-shift	dna-mobility-shift	JJ	JJ	_	20	amod	_	_
20	assays	assay	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	22	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF(P)	nf(p)	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	DNA	dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	4	dep	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	specifically	specifically	RB	RB	_	12	advmod	_	_
12	recognizes	recognize	VBZ	VBZ	_	9	acl:relcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	P	p	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	12	dobj	_	_
16	)	)	-RRB-	-RRB-	_	9	punct	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	P	p	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	2	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	abolished	abolish	VBN	VBN	_	0	root	_	_
23	when	when	WRB	WRB	_	29	advmod	_	_
24	oligonucleotides	oligonucleotide	NNS	NNS	_	29	nsubjpass	_	_
25	carrying	carry	VBG	VBG	_	24	acl	_	_
26	base	base	NN	NN	_	27	compound	_	_
27	substitutions	substitution	NNS	NNS	_	25	dobj	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	used	use	VBN	VBN	_	22	advcl	_	_
30	,	,	,	,	_	22	punct	_	_
31	indicating	indicate	VBG	VBG	_	22	xcomp	_	_
32	that	that	IN	IN	_	37	mark	_	_
33	the	the	DT	DT	_	35	det	_	_
34	NF(P)	nf(p)	NN	NN	_	35	compound	_	_
35	interaction	interaction	NN	NN	_	37	nsubj	_	_
36	is	be	VBZ	VBZ	_	37	cop	_	_
37	sequence-specific	sequence-specific	JJ	JJ	_	31	ccomp	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	that	that	IN	IN	_	45	mark	_	_
40	binding	binding	NN	NN	_	41	compound	_	_
41	specificity	specificity	NN	NN	_	45	dep	_	_
42	of	of	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	protein	protein	NN	NN	_	41	nmod	_	_
45	paralleled	parallel	VBD	VBD	_	37	conj	_	_
46	the	the	DT	DT	_	48	det	_	_
47	sequence	sequence	NN	NN	_	48	compound	_	_
48	requirements	requirement	NNS	NNS	_	45	dobj	_	_
49	for	for	IN	IN	_	51	case	_	_
50	IL-4	il-4	NN	NN	_	51	compound	_	_
51	expression	expression	NN	NN	_	48	nmod	_	_
52	in	in	FW	FW	_	53	compound	_	_
53	vivo	vivo	FW	FW	_	48	advmod	_	_
54	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	P	p	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	share	share	VB	VB	_	0	root	_	_
7	homology	homology	NN	NN	_	6	dobj	_	_
8	with	with	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	5'	5'	JJ	JJ	_	11	nmod:npmod	_	_
11	upstream	upstream	JJ	JJ	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	even	even	RB	RB	_	26	advmod	_	_
19	though	though	IN	IN	_	26	mark	_	_
20	surrounding	surround	VBG	VBG	_	21	amod	_	_
21	sequences	sequence	NNS	NNS	_	26	nsubj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-4	il-4	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	21	nmod	_	_
26	share	share	NN	NN	_	6	advcl	_	_
27	high	high	JJ	JJ	_	28	amod	_	_
28	homology	homology	NN	NN	_	26	dobj	_	_
29	with	with	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	IL-2	il-2	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	a	a	DT	DT	_	6	det	_	_
5	different	different	JJ	JJ	_	6	amod	_	_
6	set	set	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	proteins	protein	NNS	NNS	_	6	nmod	_	_
9	recognize	recognize	VBP	VBP	_	2	ccomp	_	_
10	IL-2	il-2	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-4	il-4	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	9	dobj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	three	three	CD	CD	_	8	nummod	_	_
6	different	different	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	types	type	NNS	NNS	_	3	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	major	major	JJ	JJ	_	12	amod	_	_
11	depressive	depressive	JJ	JJ	_	12	amod	_	_
12	disorder	disorder	NN	NN	_	8	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	lack	lack	NN	NN	_	3	dep	_	_
15	of	of	IN	IN	_	16	case	_	_
16	evidence	evidence	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	defect	defect	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	1	1	LS	LS	_	40	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	In	in	IN	IN	_	7	mark	_	_
4	order	order	NN	NN	_	3	mwe	_	_
5	to	to	TO	TO	_	7	dep	_	_
6	further	further	RB	RB	_	7	advmod	_	_
7	understand	understand	VB	VB	_	40	advcl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	apparent	apparent	JJ	JJ	_	11	amod	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	resistance	resistance	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	major	major	JJ	JJ	_	15	amod	_	_
14	depressive	depressive	JJ	JJ	_	15	amod	_	_
15	disorder	disorder	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	40	punct	_	_
17	circadian	circadian	JJ	JJ	_	18	amod	_	_
18	variation	variation	NN	NN	_	40	nsubjpass	_	_
19	in	in	IN	IN	_	21	case	_	_
20	cortisol	cortisol	NN	NN	_	21	compound	_	_
21	concentration	concentration	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	dexamethasone	dexamethasone	NN	NN	_	24	compound	_	_
24	suppression	suppression	NN	NN	_	18	conj	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	28	compound	_	_
27	receptor	receptor	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	18	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	mononuclear	mononuclear	JJ	JJ	_	31	amod	_	_
31	leukocytes	leukocyte	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	polymorphonuclear	polymorphonuclear	JJ	JJ	_	34	amod	_	_
34	leukocytes	leukocyte	NNS	NNS	_	31	conj	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	cultured	culture	VBN	VBN	_	38	amod	_	_
37	skin	skin	NN	NN	_	38	compound	_	_
38	fibroblasts	fibroblast	NNS	NNS	_	31	conj	_	_
39	were	be	VBD	VBD	_	40	auxpass	_	_
40	measured	measure	VBN	VBN	_	0	root	_	_
41	in	in	IN	IN	_	47	case	_	_
42	rigidly	rigidly	RB	RB	_	43	advmod	_	_
43	defined	define	VBN	VBN	_	47	amod	_	_
44	major	major	JJ	JJ	_	47	amod	_	_
45	depressive	depressive	JJ	JJ	_	47	amod	_	_
46	disorder	disorder	NN	NN	_	47	compound	_	_
47	patients	patient	NNS	NNS	_	40	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	non-depressed	non-depressed	JJ	JJ	_	51	amod	_	_
50	psychiatric	psychiatric	JJ	JJ	_	51	amod	_	_
51	controls	control	NNS	NNS	_	47	conj	_	_
52	.	.	.	.	_	40	punct	_	_

1	2	2	LS	LS	_	8	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	leukocytes	leukocyte	NNS	NNS	_	8	nsubj	_	_
5	binding	bind	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	7	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	5	nmod	_	_
8	correlated	correlate	VBD	VBD	_	0	root	_	_
9	significantly	significantly	RB	RB	_	8	advmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	polymorphonuclear	polymorphonuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	binding	bind	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	but	but	CC	CC	_	8	cc	_	_
18	both	both	DT	DT	_	19	det	_	_
19	determinations	determination	NNS	NNS	_	20	nsubj	_	_
20	failed	fail	VBD	VBD	_	8	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	differentiate	differentiate	VB	VB	_	20	xcomp	_	_
23	major	major	JJ	JJ	_	25	amod	_	_
24	depressive	depressive	JJ	JJ	_	25	amod	_	_
25	disorder	disorder	NN	NN	_	22	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	control	control	NN	NN	_	28	compound	_	_
28	subjects	subject	NNS	NNS	_	25	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	3	3	LS	LS	_	14	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Initial	initial	JJ	JJ	_	8	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	post-dexamethasone	post-dexamethasone	JJ	JJ	_	3	conj	_	_
6	in	in	FW	FW	_	8	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	fibroblast	fibroblast	NN	NN	_	14	nsubj	_	_
9	binding	bind	VBG	VBG	_	8	acl	_	_
10	to	to	TO	TO	_	11	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	different	different	JJ	JJ	_	0	root	_	_
15	between	between	IN	IN	_	18	case	_	_
16	major	major	JJ	JJ	_	18	amod	_	_
17	depressive	depressive	JJ	JJ	_	18	amod	_	_
18	disorder	disorder	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	non-depressed	non-depressed	JJ	JJ	_	22	amod	_	_
21	control	control	NN	NN	_	22	compound	_	_
22	subjects	subject	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	14	punct	_	_

1	4	4	LS	LS	_	12	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	phenomenon	phenomenon	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	resistance	resistance	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	depressive	depressive	JJ	JJ	_	11	amod	_	_
11	disorder	disorder	NN	NN	_	4	nmod	_	_
12	remains	remain	VBZ	VBZ	_	0	root	_	_
13	unexplained	unexplained	JJ	JJ	_	12	xcomp	_	_
14	.	.	.	.	_	12	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Hormonal	hormonal	JJ	JJ	_	3	amod	_	_
3	interactions	interaction	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	3	conj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	3	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nephrotic	nephrotic	JJ	JJ	_	12	amod	_	_
12	syndrome	syndrome	NN	NN	_	8	nmod	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	As	as	RB	RB	_	4	advmod	_	_
2	many	many	JJ	JJ	_	4	advmod	_	_
3	as	as	IN	IN	_	4	advmod	_	_
4	27	27	CD	CD	_	5	nummod	_	_
5	children	child	NNS	NNS	_	16	nsubjpass	_	_
6	aged	aged	JJ	JJ	_	5	amod	_	_
7	6	6	CD	CD	_	9	compound	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	15	15	CD	CD	_	10	nummod	_	_
10	years	year	NNS	NNS	_	6	nmod:tmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	morphologically	morphologically	RB	RB	_	13	advmod	_	_
13	verified	verify	VBN	VBN	_	14	amod	_	_
14	nephropathies	nephropathy	NNS	NNS	_	5	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Four	four	CD	CD	_	2	nummod	_	_
2	variants	variant	NNS	NNS	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	changes	change	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	thyroid	thyroid	NN	NN	_	8	compound	_	_
8	status	status	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	characteristic	characteristic	JJ	JJ	_	8	amod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	children	child	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	variants	variant	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	nephrotic	nephrotic	JJ	JJ	_	18	amod	_	_
18	syndrome	syndrome	NN	NN	_	15	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	distinguished	distinguish	VBN	VBN	_	0	root	_	_
21	:	:	:	:	_	20	punct	_	_
22	1	1	LS	LS	_	25	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	biochemical	biochemical	JJ	JJ	_	25	amod	_	_
25	signs	sign	NNS	NNS	_	20	dep	_	_
26	of	of	IN	IN	_	28	case	_	_
27	primary	primary	JJ	JJ	_	28	amod	_	_
28	hypothyroidism	hypothyroidism	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	2	2	LS	LS	_	33	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	biochemical	biochemical	JJ	JJ	_	33	amod	_	_
33	signs	sign	NNS	NNS	_	25	appos	_	_
34	of	of	IN	IN	_	36	case	_	_
35	secondary	secondary	JJ	JJ	_	36	amod	_	_
36	hypothyroidism	hypothyroidism	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	25	punct	_	_
38	3	3	LS	LS	_	41	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	low	low	JJ	JJ	_	41	amod	_	_
41	content	content	NN	NN	_	25	appos	_	_
42	of	of	IN	IN	_	43	case	_	_
43	T3	t3	NN	NN	_	41	nmod	_	_
44	,	,	,	,	_	25	punct	_	_
45	4	4	LS	LS	_	47	dep	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	dysfunction	dysfunction	NN	NN	_	25	appos	_	_
48	of	of	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	dep	_	_
50	hypophyseal	hypophyseal	NN	NN	_	47	nmod	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	thyroid	thyroid	NN	NN	_	50	conj	_	_
53	system	system	NN	NN	_	50	dep	_	_
54	.	.	.	.	_	20	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	32	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	low	low	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	32	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	thyroid	thyroid	NN	NN	_	13	compound	_	_
13	hormones	hormone	NNS	NNS	_	10	conj	_	_
14	that	that	IN	IN	_	16	dep	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	low	low	JJ	JJ	_	13	dep	_	_
17	level	level	NN	NN	_	16	dep	_	_
18	of	of	IN	IN	_	16	dep	_	_
19	steroid	steroid	NN	NN	_	16	dep	_	_
20	receptors	receptor	NNS	NNS	_	16	dep	_	_
21	,	,	,	,	_	16	punct	_	_
22	thyroid	thyroid	NN	NN	_	16	dep	_	_
23	hormones	hormone	NNS	NNS	_	16	dep	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	T3	t3	NN	NN	_	13	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	T4	t4	NN	NN	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	cortisol	cortisol	NN	NN	_	10	conj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	typical	typical	JJ	JJ	_	3	ccomp	_	_
33	of	of	IN	IN	_	34	case	_	_
34	children	child	NNS	NNS	_	32	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	signs	sign	NNS	NNS	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	renal	renal	JJ	JJ	_	40	amod	_	_
40	dysplasia	dysplasia	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	assumed	assume	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	superaddition	superaddition	NN	NN	_	18	nsubj	_	_
6	under	under	IN	IN	_	8	case	_	_
7	such	such	JJ	JJ	_	8	amod	_	_
8	conditions	condition	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	glomerulopathy	glomerulopathy	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	glomerulonephritis	glomerulonephritis	NN	NN	_	11	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nephrotic	nephrotic	JJ	JJ	_	16	amod	_	_
16	syndrome	syndrome	NN	NN	_	13	conj	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	gives	give	VBZ	VBZ	_	3	ccomp	_	_
19	rise	rise	NN	NN	_	18	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	resistance	resistance	NN	NN	_	18	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	treatment	treatment	NN	NN	_	22	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	glucocorticoids	glucocorticoid	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Kinetics	kinetics	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	translocation	translocation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	turnover	turnover	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	vitamin	vitamin	NN	NN	_	11	compound	_	_
10	D	d	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	HL60	hl60	NN	NN	_	16	compound	_	_
15	leukemia	leukemia	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	1	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	16	conj	_	_
21	--	--	:	:	_	1	punct	_	_
22	coincident	coincident	JJ	JJ	_	23	amod	_	_
23	rise	rise	NN	NN	_	1	dep	_	_
24	of	of	IN	IN	_	26	case	_	_
25	DNA-relaxing	dna-relaxing	JJ	JJ	_	26	amod	_	_
26	activity	activity	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	extracts	extract	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	High	high	JJ	JJ	_	3	amod	_	_
2	affinity	affinity	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	13	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	VDR	vdr	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	for	for	IN	IN	_	8	case	_	_
8	1,25-dihydroxycholecalciferol	1,25-dihydroxycholecalciferol	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	calcitriol	calcitriol	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	HL60	hl60	NN	NN	_	18	compound	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	leukemia	leukemia	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	low	low	JJ	JJ	_	22	amod	_	_
22	numbers	number	NNS	NNS	_	18	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
25	blood	blood	NN	NN	_	26	compound	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PBL	pbl	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	13	punct	_	_

1	HL60	hl60	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	expressing	express	VBG	VBG	_	2	acl	_	_
5	some	some	DT	DT	_	6	det	_	_
6	characteristics	characteristic	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	promyelocytes	promyelocyte	NNS	NNS	_	6	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	monocytoid	monocytoid	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	calcitriol	calcitriol	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	-LSB-3H-RSB-calcitriol/VDR	-lsb-3h-rsb-calcitriol/vdr	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	examined	examine	VBN	VBN	_	0	root	_	_
8	after	after	IN	IN	_	9	case	_	_
9	exposure	exposure	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	whole	whole	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	10(-9)	10(-9)	CD	CD	_	15	compound	_	_
15	M/l	m/l	NN	NN	_	16	amod	_	_
16	calcitriol	calcitriol	NN	NN	_	9	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	presence	presence	NN	NN	_	9	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	absence	absence	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	500-fold	500-fold	JJ	JJ	_	25	amod	_	_
25	excess	excess	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	unlabeled	unlabeled	JJ	JJ	_	28	amod	_	_
28	ligand	ligand	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	9	cc	_	_
30	subsequent	subsequent	JJ	JJ	_	31	amod	_	_
31	isolation	isolation	NN	NN	_	9	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	nuclei	nucleus	NNS	NNS	_	31	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	-LSB-3H-RSB-calcitriol/VDR	-lsb-3h-rsb-calcitriol/vdr	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	11	mark	_	_
9	be	be	VB	VB	_	11	cop	_	_
10	time	time	NN	NN	_	11	nmod:npmod	_	_
11	dependent	dependent	JJ	JJ	_	7	xcomp	_	_
12	reaching	reach	VBG	VBG	_	11	xcomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	maximum	maximum	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	approximately	approximately	RB	RB	_	17	advmod	_	_
17	2100	2100	CD	CD	_	19	nummod	_	_
18	binding	bind	VBG	VBG	_	19	amod	_	_
19	sites/nucleus	sites/nucleus	NNS	NNS	_	14	nmod	_	_
20	after	after	IN	IN	_	22	case	_	_
21	3	3	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	12	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	incubation	incubation	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	HL60	hl60	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	,	,	,	,	_	7	punct	_	_
29	whereas	whereas	IN	IN	_	7	dep	_	_
30	a	a	DT	DT	_	31	det	_	_
31	maximum	maximum	NN	NN	_	38	nsubjpass	_	_
32	of	of	IN	IN	_	36	case	_	_
33	approximately	approximately	RB	RB	_	34	advmod	_	_
34	310	310	CD	CD	_	36	nummod	_	_
35	binding	bind	VBG	VBG	_	36	amod	_	_
36	sites/nucleus	sites/nucleus	NNS	NNS	_	31	nmod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	found	find	VBN	VBN	_	7	parataxis	_	_
39	after	after	IN	IN	_	41	case	_	_
40	3	3	CD	CD	_	41	nummod	_	_
41	h	h	NN	NN	_	38	nmod	_	_
42	in	in	IN	IN	_	43	case	_	_
43	PBL	pbl	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	7	punct	_	_

1	Pulse	pulse	NN	NN	_	2	compound	_	_
2	exposure	exposure	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HL60	hl60	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	radiolabeled	radiolabele	VBN	VBN	_	7	amod	_	_
7	hormone	hormone	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	3	3	CD	CD	_	10	nummod	_	_
10	h	h	NN	NN	_	2	nmod	_	_
11	followed	follow	VBN	VBN	_	2	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	culture	culture	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	medium	medium	NN	NN	_	13	nmod	_	_
16	without	without	IN	IN	_	17	case	_	_
17	serum	serum	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	calcitriol	calcitriol	NN	NN	_	17	conj	_	_
20	lead	lead	VBD	VBD	_	0	root	_	_
21	to	to	TO	TO	_	23	case	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	retention	retention	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	approximately	approximately	RB	RB	_	26	advmod	_	_
26	1600	1600	CD	CD	_	28	nummod	_	_
27	radiolabeled	radiolabele	VBN	VBN	_	28	amod	_	_
28	VDR	vdr	NN	NN	_	23	nmod	_	_
29	by	by	IN	IN	_	31	case	_	_
30	8	8	CD	CD	_	31	nummod	_	_
31	h	h	NN	NN	_	23	nmod	_	_
32	and	and	CC	CC	_	23	cc	_	_
33	approximately	approximately	RB	RB	_	34	advmod	_	_
34	1000	1000	CD	CD	_	35	nummod	_	_
35	VDR	vdr	NN	NN	_	23	conj	_	_
36	by	by	IN	IN	_	38	case	_	_
37	24	24	CD	CD	_	38	nummod	_	_
38	h	h	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	20	punct	_	_

1	Radiolabeled	radiolabele	VBN	VBN	_	2	amod	_	_
2	VDR	vdr	NN	NN	_	3	nsubj	_	_
3	disappeared	disappear	VBD	VBD	_	0	root	_	_
4	from	from	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	compartment	compartment	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	halflife	halflife	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	30	30	CD	CD	_	14	nummod	_	_
14	min	min	NN	NN	_	10	nmod	_	_
15	if	if	IN	IN	_	18	mark	_	_
16	cells	cell	NNS	NNS	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	aux	_	_
18	cultured	culture	VBN	VBN	_	3	advcl	_	_
19	with	with	IN	IN	_	21	case	_	_
20	identical	identical	JJ	JJ	_	21	amod	_	_
21	concentrations	concentration	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	unlabeled	unlabeled	JJ	JJ	_	24	amod	_	_
24	hormone	hormone	NN	NN	_	21	nmod	_	_
25	after	after	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	pulse	pulse	NN	NN	_	18	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	pulse/chase-experiments	pulse/chase-experiment	NNS	NNS	_	18	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	3	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	difference	difference	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	VDR	vdr	NN	NN	_	5	compound	_	_
5	retention	retention	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	pulse	pulse	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	pulse/chase-experiments	pulse/chase-experiment	NNS	NNS	_	7	conj	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	PBL	pbl	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	where	where	WRB	WRB	_	21	advmod	_	_
16	VDR	vdr	NN	NN	_	17	compound	_	_
17	halflife	halflife	NN	NN	_	21	nsubj	_	_
18	was	be	VBD	VBD	_	21	cop	_	_
19	approximately	approximately	RB	RB	_	20	advmod	_	_
20	30	30	CD	CD	_	21	nummod	_	_
21	min	min	NN	NN	_	13	acl:relcl	_	_
22	.	.	.	.	_	11	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	9	nsubjpass	_	_
4	into	into	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	compartment	compartment	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	seen	see	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	isolated	isolate	VBN	VBN	_	12	amod	_	_
12	nuclei	nucleus	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	incubated	incubate	VBN	VBN	_	9	advcl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	-LSB-3H-RSB-calcitriol	-lsb-3h-rsb-calcitriol	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Radiolabeled	radiolabele	VBN	VBN	_	3	amod	_	_
2	hormone/receptor	hormone/receptor	NN	NN	_	3	compound	_	_
3	complexes	complex	NNS	NNS	_	28	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	nuclei	nucleus	NNS	NNS	_	3	nmod	_	_
6	isolated	isolate	VBN	VBN	_	3	acl	_	_
7	from	from	IN	IN	_	8	case	_	_
8	cells	cell	NNS	NNS	_	6	nmod	_	_
9	exposed	expose	VBN	VBN	_	8	acl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	3	3	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	radiolabeled	radiolabele	VBN	VBN	_	15	amod	_	_
15	hormone	hormone	NN	NN	_	9	nmod	_	_
16	--	--	:	:	_	9	punct	_	_
17	in	in	IN	IN	_	21	case	_	_
18	contrast	contrast	NN	NN	_	21	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	identical	identical	JJ	JJ	_	21	amod	_	_
21	experiments	experiment	NNS	NNS	_	9	nmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	intact	intact	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	--	--	:	:	_	9	punct	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	disappear	disappear	VB	VB	_	0	root	_	_
29	from	from	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	compartment	compartment	NN	NN	_	28	nmod	_	_
33	upon	upon	IN	IN	_	34	case	_	_
34	incubation	incubation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	nuclei	nucleus	NNS	NNS	_	34	nmod	_	_
37	with	with	IN	IN	_	39	case	_	_
38	identical	identical	JJ	JJ	_	39	amod	_	_
39	concentrations	concentration	NNS	NNS	_	34	nmod	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	unlabeled	unlabeled	JJ	JJ	_	43	amod	_	_
43	compound	compound	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	relaxing	relaxing	NN	NN	_	6	compound	_	_
6	enzymes	enzyme	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	6	punct	_	_
8	e.g.	e.g.	FW	FW	_	9	dep	_	_
9	topoisomerases	topoisomerase	NNS	NNS	_	6	advmod	_	_
10	I	i	CD	CD	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	II	ii	CD	CD	_	10	conj	_	_
13	)	)	-RRB-	-RRB-	_	6	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	extracts	extract	NNS	NNS	_	6	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	measured	measure	VBN	VBN	_	0	root	_	_
19	using	use	VBG	VBG	_	18	xcomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	PBR	pbr	NN	NN	_	22	compound	_	_
22	322-relaxation-assay	322-relaxation-assay	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	18	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	4	amod	_	_
2	overall	overall	JJ	JJ	_	4	amod	_	_
3	enzyme	enzyme	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	extracts	extract	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	1	1	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	6	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	incubation	incubation	NN	NN	_	12	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	calcitriol	calcitriol	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	final	final	JJ	JJ	_	20	amod	_	_
19	ethanol	ethanol	NN	NN	_	20	compound	_	_
20	concentration	concentration	NN	NN	_	16	dep	_	_
21	0.0001	0.0001	CD	CD	_	22	compound	_	_
22	%	%	NN	NN	_	23	amod	_	_
23	v/v	v/v	NN	NN	_	20	dep	_	_
24	)	)	-RRB-	-RRB-	_	20	punct	_	_
25	in	in	IN	IN	_	26	case	_	_
26	HL60	hl60	NN	NN	_	14	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	PBL	pbl	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	enhanced	enhance	VBN	VBN	_	3	amod	_	_
3	activity	activity	NN	NN	_	4	nsubj	_	_
4	disappeared	disappear	VBD	VBD	_	0	root	_	_
5	after	after	IN	IN	_	7	case	_	_
6	2	2	CD	CD	_	7	nummod	_	_
7	h	h	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	PBL	pbl	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	whereas	whereas	IN	IN	_	4	dep	_	_
12	it	it	PRP	PRP	_	15	nsubjpass	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	still	still	RB	RB	_	15	advmod	_	_
15	enhanced	enhance	VBN	VBN	_	4	parataxis	_	_
16	by	by	IN	IN	_	18	case	_	_
17	4	4	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	HL60	hl60	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	seen	see	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	ethanol	ethanol	NN	NN	_	7	nmod:npmod	_	_
7	treated	treated	JJ	JJ	_	8	amod	_	_
8	controls	control	NNS	NNS	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	a	a	DT	DT	_	8	det	_	_
5	specific	specific	JJ	JJ	_	8	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	translocation	translocation	NN	NN	_	8	compound	_	_
8	mechanism	mechanism	NN	NN	_	9	nsubj	_	_
9	exists	exist	VBZ	VBZ	_	2	ccomp	_	_
10	for	for	IN	IN	_	11	case	_	_
11	calcitriol	calcitriol	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	both	both	DT	DT	_	15	det	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	types	type	NNS	NNS	_	9	nmod	_	_
16	examined	examine	VBN	VBN	_	15	acl	_	_
17	,	,	,	,	_	9	punct	_	_
18	most	most	RBS	RBS	_	19	advmod	_	_
19	likely	likely	RB	RB	_	22	advmod	_	_
20	due	due	IN	IN	_	22	case	_	_
21	to	to	TO	TO	_	20	mwe	_	_
22	translocation	translocation	NN	NN	_	9	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	after	after	IN	IN	_	28	case	_	_
27	hormone	hormone	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Translocated	translocate	VBN	VBN	_	3	amod	_	_
2	hormone/receptor	hormone/receptor	NN	NN	_	3	compound	_	_
3	complexes	complex	NNS	NNS	_	4	nsubj	_	_
4	compete	compete	VBP	VBP	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	limited	limited	JJ	JJ	_	8	amod	_	_
8	number	number	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	specific	specific	JJ	JJ	_	13	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	binding	bind	VBG	VBG	_	13	amod	_	_
13	sites	site	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	2	amod	_	_
2	activity	activity	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	topoisomerases	topoisomerase	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	2	nmod	_	_
8	upon	upon	IN	IN	_	9	case	_	_
9	translocation	translocation	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	VDR	vdr	NN	NN	_	9	nmod	_	_
12	might	might	MD	MD	_	13	aux	_	_
13	reflect	reflect	VB	VB	_	0	root	_	_
14	interaction	interaction	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	both	both	DT	DT	_	14	nmod	_	_
17	within	within	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	compartment	compartment	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	thus	thus	RB	RB	_	23	advmod	_	_
23	initiating	initiate	VBG	VBG	_	13	advcl	_	_
24	DNA-unwinding	dna-unwinding	NN	NN	_	23	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	prerequisite	prerequisite	NN	NN	_	24	appos	_	_
28	of	of	IN	IN	_	30	case	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	initiation	initiation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	B	b	NN	NN	_	3	nmod:npmod	_	_
3	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	OTF-2	otf-2	NN	NN	_	8	nsubj	_	_
7	positively	positively	RB	RB	_	8	advmod	_	_
8	regulates	regulate	VBZ	VBZ	_	0	root	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	class	class	NN	NN	_	16	compound	_	_
14	II	ii	CD	CD	_	16	nummod	_	_
15	transplantation	transplantation	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	9	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	DRA	dra	NN	NN	_	16	appos	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoter	promoter	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	major	major	JJ	JJ	_	10	amod	_	_
6	histocompatibility	histocompatibility	NN	NN	_	10	compound	_	_
7	class	class	NN	NN	_	10	compound	_	_
8	II	ii	CD	CD	_	10	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	DRA	dra	NN	NN	_	2	nmod	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	an	a	DT	DT	_	14	det	_	_
13	octamer	octamer	NN	NN	_	14	compound	_	_
14	element	element	NN	NN	_	11	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	ATTTGCAT	atttgcat	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	required	require	VBN	VBN	_	14	acl:relcl	_	_
21	for	for	IN	IN	_	24	case	_	_
22	efficient	efficient	JJ	JJ	_	24	amod	_	_
23	DRA	dra	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	bind	bind	VB	VB	_	5	xcomp	_	_
8	this	this	DT	DT	_	9	det	_	_
9	sequence	sequence	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	best	best	RBS	RBS	_	3	advmod	_	_
3	characterized	characterize	VBN	VBN	_	4	dep	_	_
4	are	be	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	B	b	NN	NN	_	7	nmod:npmod	_	_
7	cell-specific	cell-specific	JJ	JJ	_	8	amod	_	_
8	OTF-2	otf-2	NN	NN	_	4	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ubiquitous	ubiquitous	JJ	JJ	_	12	amod	_	_
12	OTF-1	otf-1	NN	NN	_	8	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	4	nsubj	_	_
3	directly	directly	RB	RB	_	4	advmod	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	OTF-2	otf-2	NN	NN	_	10	nsubj	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	6	cc	_	_
9	OTF-1	otf-1	NN	NN	_	6	conj	_	_
10	regulates	regulate	VBZ	VBZ	_	4	ccomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DRA	dra	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	14	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	fractions	fraction	NNS	NNS	_	5	dobj	_	_
8	enriched	enrich	VBN	VBN	_	7	amod	_	_
9	for	for	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	octamer-binding	octamer-binding	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	OTF-2	otf-2	NN	NN	_	8	nmod	_	_
14	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
15	a	a	DT	DT	_	18	det	_	_
16	positive	positive	JJ	JJ	_	18	amod	_	_
17	functional	functional	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	14	dobj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	OTF-2	otf-2	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	DRA	dra	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	transcription	transcription	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	OTF-1-enriched	otf-1-enriched	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	fractions	fraction	NNS	NNS	_	9	nsubj	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	affect	affect	VB	VB	_	0	root	_	_
10	DRA	dra	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	9	dobj	_	_
13	although	although	IN	IN	_	16	mark	_	_
14	it	it	PRP	PRP	_	16	nsubj	_	_
15	functionally	functionally	RB	RB	_	16	advmod	_	_
16	enhanced	enhance	VBD	VBD	_	9	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	transcription	transcription	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	another	another	DT	DT	_	21	det	_	_
21	gene	gene	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	3	amod	_	_
2	OTF-2	otf-2	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	11	nsubj	_	_
4	produced	produce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	in	in	FW	FW	_	8	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	transcription/translation	transcription/translation	NN	NN	_	4	nmod	_	_
9	could	could	MD	MD	_	11	aux	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	enhance	enhance	VB	VB	_	0	root	_	_
12	DRA	dra	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	11	dobj	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	11	advmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	In	in	FW	FW	_	5	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	transient	transient	JJ	JJ	_	5	amod	_	_
4	transfection	transfection	NN	NN	_	5	compound	_	_
5	studies	study	NNS	NNS	_	11	nsubj	_	_
6	utilizing	utilize	VBG	VBG	_	5	acl	_	_
7	an	a	DT	DT	_	10	det	_	_
8	OTF-2	otf-2	NN	NN	_	10	compound	_	_
9	expression	expression	NN	NN	_	10	compound	_	_
10	vector	vector	NN	NN	_	6	dobj	_	_
11	resulted	result	VBD	VBD	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	similar	similar	JJ	JJ	_	14	amod	_	_
14	findings	finding	NNS	NNS	_	11	nmod	_	_
15	:	:	:	:	_	14	punct	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	OTF-2	otf-2	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	19	nsubj	_	_
19	enhanced	enhance	VBD	VBD	_	14	ccomp	_	_
20	DRA	dra	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	19	punct	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	that	that	IN	IN	_	28	mark	_	_
26	this	this	DT	DT	_	27	det	_	_
27	effect	effect	NN	NN	_	28	nsubj	_	_
28	requires	require	VBZ	VBZ	_	19	conj	_	_
29	an	a	DT	DT	_	32	det	_	_
30	intact	intact	JJ	JJ	_	32	amod	_	_
31	octamer	octamer	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	28	dobj	_	_
33	.	.	.	.	_	11	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	constitute	constitute	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	first	first	JJ	JJ	_	8	amod	_	_
7	direct	direct	JJ	JJ	_	8	amod	_	_
8	evidence	evidence	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	positive	positive	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	8	nmod	_	_
13	for	for	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	lymphoid-specific	lymphoid-specific	JJ	JJ	_	17	amod	_	_
16	octamer-binding	octamer-binding	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	DRA	dra	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	12	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
5	cholesterol	cholesterol	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	hypercholesterolemia	hypercholesterolemia	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
11	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rate	rate	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	endogenous	endogenous	JJ	JJ	_	6	amod	_	_
5	cholesterol	cholesterol	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	blood	blood	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	skin	skin	NN	NN	_	12	compound	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	9	conj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	9	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	type	type	NN	NN	_	18	compound	_	_
17	IIa	iia	NN	NN	_	18	compound	_	_
18	hyperlipidemia	hyperlipidemia	NN	NN	_	14	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	increased	increase	VBN	VBN	_	20	xcomp	_	_
24	in	in	IN	IN	_	28	case	_	_
25	comparison	comparison	NN	NN	_	28	dep	_	_
26	with	with	IN	IN	_	28	case	_	_
27	healthy	healthy	JJ	JJ	_	28	amod	_	_
28	donors	donor	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	hyperlipidemic	hyperlipidemic	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	lowered	lowered	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	concomitantly	concomitantly	RB	RB	_	16	advmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	partial	partial	JJ	JJ	_	16	amod	_	_
16	loss	loss	NN	NN	_	6	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	sensitivity	sensitivity	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	glucocorticoids	glucocorticoid	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fibroblasts	fibroblast	NNS	NNS	_	18	nmod	_	_
3	from	from	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	hereditary	hereditary	JJ	JJ	_	7	amod	_	_
7	hypercholesteremia	hypercholesteremia	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	homozygous	homozygous	JJ	JJ	_	10	amod	_	_
10	type	type	NN	NN	_	7	nmod	_	_
11	the	the	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	18	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	12	nmod	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	exceed	exceed	VB	VB	_	0	root	_	_
19	10	10	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	content	content	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	normal	normal	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	type	type	NN	NN	_	14	compound	_	_
13	IIa	iia	NN	NN	_	14	compound	_	_
14	hyperlipidemia	hyperlipidemia	NN	NN	_	10	nmod	_	_
15	seems	seem	VBZ	VBZ	_	0	root	_	_
16	to	to	TO	TO	_	20	mark	_	_
17	be	be	VB	VB	_	20	cop	_	_
18	a	a	DT	DT	_	20	det	_	_
19	compensatory	compensatory	JJ	JJ	_	20	amod	_	_
20	response	response	NN	NN	_	15	xcomp	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cells	cell	NNS	NNS	_	20	nmod	_	_
23	culminating	culminate	VBG	VBG	_	22	acl	_	_
24	in	in	IN	IN	_	25	case	_	_
25	activation	activation	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	endogenous	endogenous	JJ	JJ	_	29	amod	_	_
28	cholesterol	cholesterol	NN	NN	_	29	compound	_	_
29	synthesis	synthesis	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	stimulation	stimulation	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	expression	expression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	genes	gene	NNS	NNS	_	3	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	6	dobj	_	_
9	:	:	:	:	_	1	punct	_	_
10	c-fos	c-fos	NN	NN	_	23	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	c-jun	c-jun	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	formation	formation	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	AP1	ap1	NN	NN	_	18	compound	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	complex	complex	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	investigated	investigate	VBN	VBN	_	1	dep	_	_
24	.	.	.	.	_	23	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	3	ccomp	_	_
7	strongly	strongly	RB	RB	_	6	advmod	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	c-fos	c-fos	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	c-jun	c-jun	NN	NN	_	9	conj	_	_
12	expression	expression	NN	NN	_	6	dobj	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	AP1	ap1	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Interferon	interferon	NN	NN	_	2	compound	_	_
2	gamma	gamma	NN	NN	_	3	nsubj	_	_
3	activated	activate	VBD	VBD	_	0	root	_	_
4	strongly	strongly	RB	RB	_	3	advmod	_	_
5	c-fos	c-fos	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	weakly	weakly	RB	RB	_	8	advmod	_	_
8	c-jun	c-jun	NN	NN	_	3	conj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP1	ap1	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	3	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	necrosis	necrosis	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	slightly	slightly	RB	RB	_	4	advmod	_	_
6	c-fos	c-fos	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	had	have	VBD	VBD	_	4	conj	_	_
9	almost	almost	RB	RB	_	10	advmod	_	_
10	no	no	DT	DT	_	11	nummod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	13	case	_	_
13	c-jun	c-jun	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	AP1	ap1	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	differences	difference	NNS	NNS	_	18	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	5	nmod	_	_
9	elicited	elicit	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	all	all	DT	DT	_	14	advmod	_	_
14	three	three	CD	CD	_	15	nummod	_	_
15	factors	factor	NNS	NNS	_	9	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
19	on	on	IN	IN	_	21	case	_	_
20	different	different	JJ	JJ	_	21	amod	_	_
21	routes	route	NNS	NNS	_	18	nmod	_	_
22	on	on	IN	IN	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	signalling	signalling	NN	NN	_	21	nmod	_	_
25	employed	employ	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Corticosteroid	corticosteroid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	subsets	subset	NNS	NNS	_	2	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	aging	aging	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Plasma	plasma	NN	NN	_	2	compound	_	_
2	cortisol	cortisol	NN	NN	_	15	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	aldosterone	aldosterone	NN	NN	_	2	conj	_	_
5	levels	level	NNS	NNS	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	number	number	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	related	related	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	measured	measure	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	49	49	CD	CD	_	20	nummod	_	_
18	healthy	healthy	JJ	JJ	_	20	amod	_	_
19	aged	aged	JJ	JJ	_	20	amod	_	_
20	subjects	subject	NNS	NNS	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	62-97	62-97	CD	CD	_	23	nummod	_	_
23	yr	yr	NN	NN	_	20	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	in	in	IN	IN	_	29	case	_	_
27	21	21	CD	CD	_	29	nummod	_	_
28	adult	adult	JJ	JJ	_	29	amod	_	_
29	controls	control	NNS	NNS	_	20	conj	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	21-50	21-50	CD	CD	_	32	nummod	_	_
32	yr	yr	NN	NN	_	29	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	all	all	DT	DT	_	3	det	_	_
3	subjects	subject	NNS	NNS	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	in	in	IN	IN	_	6	case	_	_
6	addition	addition	NN	NN	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	subsets	subset	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	determined	determine	VBN	VBN	_	0	root	_	_
12	as	as	IN	IN	_	14	case	_	_
13	an	a	DT	DT	_	14	det	_	_
14	index	index	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	corticosteroid	corticosteroid	NN	NN	_	17	compound	_	_
17	action	action	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mean	mean	NN	NN	_	3	compound	_	_
3	number	number	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	10	case	_	_
5	type	type	NN	NN	_	10	compound	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	type	type	NN	NN	_	5	conj	_	_
9	II	ii	CD	CD	_	8	nummod	_	_
10	receptors	receptor	NNS	NNS	_	3	nmod	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	lower	lower	JJR	JJR	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	aged	aged	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	13	nmod	_	_
17	than	than	IN	IN	_	19	case	_	_
18	in	in	IN	IN	_	19	case	_	_
19	controls	control	NNS	NNS	_	13	advcl	_	_
20	(	(	-LRB-	-LRB-	_	30	punct	_	_
21	respectively	respectively	RB	RB	_	30	dep	_	_
22	,	,	,	,	_	30	punct	_	_
23	198	198	CD	CD	_	30	nummod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	96	96	CD	CD	_	23	conj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	272	272	CD	CD	_	25	conj	_	_
28	+/-	+/-	CC	CC	_	27	cc	_	_
29	97	97	CD	CD	_	27	conj	_	_
30	receptors/cell	receptors/cell	NNS	NNS	_	13	dep	_	_
31	for	for	IN	IN	_	32	case	_	_
32	type	type	NN	NN	_	30	nmod	_	_
33	I	i	CD	CD	_	32	nummod	_	_
34	,	,	,	,	_	30	punct	_	_
35	and	and	CC	CC	_	30	cc	_	_
36	1,794	1,794	CD	CD	_	30	conj	_	_
37	+/-	+/-	CC	CC	_	36	cc	_	_
38	803	803	CD	CD	_	36	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	3,339	3,339	CD	CD	_	38	conj	_	_
41	+/-	+/-	CC	CC	_	40	cc	_	_
42	918	918	CD	CD	_	40	conj	_	_
43	for	for	IN	IN	_	44	case	_	_
44	type	type	NN	NN	_	36	nmod	_	_
45	II	ii	CD	CD	_	44	nummod	_	_
46	receptors	receptor	NNS	NNS	_	30	dep	_	_
47	)	)	-RRB-	-RRB-	_	30	punct	_	_
48	.	.	.	.	_	13	punct	_	_

1	Plasma	plasma	NN	NN	_	10	nsubj	_	_
2	aldosterone	aldosterone	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cortisol	cortisol	NN	NN	_	2	conj	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	subsets	subset	NNS	NNS	_	1	conj	_	_
8	were	be	VBD	VBD	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	different	different	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	groups	group	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	All	all	DT	DT	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	parameters	parameter	NNS	NNS	_	1	nmod	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	tested	test	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	correlation	correlation	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	a	a	DT	DT	_	15	det	_	_
13	significant	significant	JJ	JJ	_	15	amod	_	_
14	inverse	inverse	JJ	JJ	_	15	amod	_	_
15	correlation	correlation	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	7	conj	_	_
18	between	between	IN	IN	_	19	case	_	_
19	age	age	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	type	type	NN	NN	_	26	compound	_	_
22	I	i	CD	CD	_	21	nummod	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	type	type	NN	NN	_	21	conj	_	_
25	II	ii	CD	CD	_	24	nummod	_	_
26	receptors	receptor	NNS	NNS	_	19	conj	_	_
27	when	when	WRB	WRB	_	31	advmod	_	_
28	all	all	DT	DT	_	29	det	_	_
29	subjects	subject	NNS	NNS	_	31	nsubjpass	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	plotted	plot	VBN	VBN	_	17	advcl	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	between	between	IN	IN	_	34	case	_	_
34	aged	aged	JJ	JJ	_	31	conj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	CD4	cd4	NN	NN	_	34	conj	_	_
37	and	and	CC	CC	_	34	cc	_	_
38	age	age	NN	NN	_	34	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	CD4/CD8	cd4/cd8	NN	NN	_	38	conj	_	_
41	in	in	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	aged	aged	JJ	JJ	_	44	amod	_	_
44	group	group	NN	NN	_	31	nmod	_	_
45	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	aged	aged	JJ	JJ	_	6	amod	_	_
6	subjects	subject	NNS	NNS	_	7	nsubj	_	_
7	have	have	VBP	VBP	_	3	ccomp	_	_
8	reductions	reduction	NNS	NNS	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	corticosteroid	corticosteroid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	15	nsubjpass	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	associated	associate	VBN	VBN	_	8	acl:relcl	_	_
16	with	with	IN	IN	_	17	case	_	_
17	increase	increase	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	related	related	JJ	JJ	_	20	amod	_	_
20	steroids	steroid	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	this	this	DT	DT	_	24	det	_	_
24	situation	situation	NN	NN	_	26	nsubj	_	_
25	probably	probably	RB	RB	_	26	advmod	_	_
26	represents	represent	VBZ	VBZ	_	7	conj	_	_
27	a	a	DT	DT	_	28	det	_	_
28	concomitant	concomitant	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	normal	normal	JJ	JJ	_	33	amod	_	_
32	aging	aging	NN	NN	_	33	compound	_	_
33	process	process	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Stable	stable	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HB24	hb24	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	10	det	_	_
7	diverged	diverged	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	homeobox	homeobox	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	4	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
15	induces	induce	VBZ	VBZ	_	0	root	_	_
16	genes	gene	NNS	NNS	_	15	dobj	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	17	nmod	_	_
21	activation	activation	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	growth	growth	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	diverged	diverged	JJ	JJ	_	4	amod	_	_
3	homeobox	homeobox	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	19	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	HB24	hb24	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	which	which	WDT	WDT	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	known	know	VBN	VBN	_	4	acl:relcl	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	10	xcomp	_	_
14	following	follow	VBG	VBG	_	16	case	_	_
15	lymphocyte	lymphocyte	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	introduced	introduce	VBN	VBN	_	0	root	_	_
20	into	into	IN	IN	_	23	case	_	_
21	Jurkat	jurkat	NN	NN	_	23	compound	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	under	under	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	control	control	NN	NN	_	19	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	constitutive	constitutive	JJ	JJ	_	30	amod	_	_
30	promoter	promoter	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	Stable	stable	JJ	JJ	_	2	amod	_	_
2	transfectants	transfectant	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HB24	hb24	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	established	establish	VBN	VBN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	expressed	express	VBD	VBD	_	6	ccomp	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	HB24	hb24	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	possessed	possess	VBD	VBD	_	8	conj	_	_
16	an	a	DT	DT	_	18	det	_	_
17	altered	altered	JJ	JJ	_	18	amod	_	_
18	phenotype	phenotype	NN	NN	_	15	dobj	_	_
19	suggestive	suggestive	JJ	JJ	_	18	amod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	activated	activate	VBN	VBN	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	genes	gene	NNS	NNS	_	2	nmod	_	_
5	known	know	VBN	VBN	_	4	dep	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	5	xcomp	_	_
9	following	follow	VBG	VBG	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	associated	associate	VBN	VBN	_	5	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	growth	growth	NN	NN	_	14	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	increased	increase	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	transfectants	transfectant	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	including	include	VBG	VBG	_	25	case	_	_
25	c-fos	c-fos	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	c-myc	c-myc	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	c-myb	c-myb	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	HLA-DR	hla-dr	NN	NN	_	25	conj	_	_
32	,	,	,	,	_	25	punct	_	_
33	lck	lck	NN	NN	_	25	conj	_	_
34	,	,	,	,	_	25	punct	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	25	conj	_	_
37	,	,	,	,	_	25	punct	_	_
38	interleukin-2	interleukin-2	NN	NN	_	25	conj	_	_
39	and	and	CC	CC	_	25	cc	_	_
40	interleukin-2	interleukin-2	NN	NN	_	42	compound	_	_
41	receptor	receptor	NN	NN	_	42	compound	_	_
42	alpha	alpha	NN	NN	_	25	conj	_	_
43	(	(	-LRB-	-LRB-	_	45	punct	_	_
44	IL-2R	il-2r	NN	NN	_	45	compound	_	_
45	alpha	alpha	NN	NN	_	42	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	.	.	.	.	_	19	punct	_	_

1	Analysis	analysis	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IL-2R	il-2r	NN	NN	_	5	compound	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	transient	transient	JJ	JJ	_	8	amod	_	_
8	transfection	transfection	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	IL-2R	il-2r	NN	NN	_	13	compound	_	_
11	alpha	alpha	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	constructs	construct	NNS	NNS	_	8	nmod	_	_
14	into	into	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HB24	hb24	NN	NN	_	17	compound	_	_
17	transfectants	transfectant	NNS	NNS	_	8	nmod	_	_
18	revealed	reveal	VBD	VBD	_	0	root	_	_
19	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	about	about	RB	RB	_	23	advmod	_	_
23	60	60	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	20	dep	_	_
25	of	of	IN	IN	_	31	case	_	_
26	phytohemagglutinin-	phytohemagglutinin-	NN	NN	_	31	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	phorbol	phorbol	NN	NN	_	29	nmod:npmod	_	_
29	ester-activated	ester-activated	JJ	JJ	_	26	conj	_	_
30	Jurkat	jurkat	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	24	nmod	_	_
32	)	)	-RRB-	-RRB-	_	24	punct	_	_
33	that	that	WDT	WDT	_	35	nsubj	_	_
34	was	be	VBD	VBD	_	35	cop	_	_
35	dependent	dependent	JJ	JJ	_	20	acl:relcl	_	_
36	on	on	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	kappa	kappa	NN	NN	_	40	compound	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	site	site	NN	NN	_	35	nmod	_	_
41	in	in	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	IL-2R	il-2r	NN	NN	_	45	compound	_	_
44	alpha	alpha	NN	NN	_	45	compound	_	_
45	promoter	promoter	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	18	punct	_	_

1	Furthermore	furthermore	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	as	as	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	consequence	consequence	NN	NN	_	17	nmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	increased	increase	VBN	VBN	_	11	amod	_	_
9	HB24	hb24	NN	NN	_	11	compound	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	17	punct	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	HB24	hb24	NN	NN	_	16	compound	_	_
16	transfectants	transfectant	NNS	NNS	_	17	nsubj	_	_
17	proliferated	proliferate	VBD	VBD	_	0	root	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	rapidly	rapidly	RB	RB	_	17	advmod	_	_
20	than	than	IN	IN	_	23	case	_	_
21	control	control	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	stable	stable	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HB24	hb24	NN	NN	_	4	nmod	_	_
7	confers	confer	VBZ	VBZ	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	activation	activation	NN	NN	_	10	compound	_	_
10	phenotype	phenotype	NN	NN	_	7	dobj	_	_
11	on	on	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	implicating	implicate	VBG	VBG	_	7	advcl	_	_
19	this	this	DT	DT	_	20	det	_	_
20	gene	gene	NN	NN	_	18	dobj	_	_
21	as	as	IN	IN	_	25	case	_	_
22	an	a	DT	DT	_	25	det	_	_
23	important	important	JJ	JJ	_	25	amod	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	factor	factor	NN	NN	_	18	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cell	cell	NN	NN	_	25	nmod	_	_
29	activation	activation	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	growth	growth	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	7	punct	_	_

1	Studies	study	NNS	NNS	_	0	root	_	_
2	on	on	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	biological	biological	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	triiodothyronine	triiodothyronine	NN	NN	_	8	compound	_	_
8	sulfate	sulfate	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Hepatic	hepatic	JJ	JJ	_	2	amod	_	_
2	microsomes	microsome	NNS	NNS	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	isolated	isolate	VBN	VBN	_	5	amod	_	_
5	hepatocytes	hepatocyte	NNS	NNS	_	2	conj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	short	short	JJ	JJ	_	9	amod	_	_
8	term	term	NN	NN	_	9	compound	_	_
9	culture	culture	NN	NN	_	2	nmod	_	_
10	desulfate	desulfate	VBP	VBP	_	0	root	_	_
11	T3	t3	NN	NN	_	12	compound	_	_
12	sulfate	sulfate	NN	NN	_	10	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	T3SO4	t3so4	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	5	nsubj	_	_
2	,	,	,	,	_	5	punct	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	wished	wish	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	5	xcomp	_	_
8	whether	whether	IN	IN	_	11	mark	_	_
9	T3SO4	t3so4	NN	NN	_	11	nsubj	_	_
10	could	could	MD	MD	_	11	aux	_	_
11	mimic	mimic	VB	VB	_	7	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	action	action	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	thyroid	thyroid	NN	NN	_	16	compound	_	_
16	hormone	hormone	NN	NN	_	13	nmod	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	11	advmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	T3SO4	t3so4	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	thyromimetic	thyromimetic	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	dobj	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activity	activity	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Ca(2+)-ATPase	ca(2+)-atpase	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	erythrocyte	erythrocyte	NN	NN	_	14	compound	_	_
14	membranes	membrane	NNS	NNS	_	8	nmod	_	_
15	at	at	IN	IN	_	16	case	_	_
16	doses	dose	NNS	NNS	_	2	nmod	_	_
17	up	up	RB	RB	_	20	advmod	_	_
18	to	to	TO	TO	_	20	dep	_	_
19	10,000	10,000	CD	CD	_	20	compound	_	_
20	times	time	NNS	NNS	_	24	nummod	_	_
21	the	the	DT	DT	_	24	det	_	_
22	maximally	maximally	RB	RB	_	23	advmod	_	_
23	effective	effective	JJ	JJ	_	24	amod	_	_
24	dose	dose	NN	NN	_	16	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	T3	t3	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	10(-10)	10(-10)	CD	CD	_	29	nummod	_	_
29	mol/L	mol/l	NN	NN	_	24	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	GH4C1	gh4c1	NN	NN	_	4	compound	_	_
3	pituitary	pituitary	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	T3SO4	t3so4	NN	NN	_	7	nsubj	_	_
7	failed	fail	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	displace	displace	VB	VB	_	7	xcomp	_	_
10	-LSB-125I-RSB-T3	-lsb-125i-rsb-t3	NN	NN	_	9	dobj	_	_
11	from	from	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	receptors	receptor	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	intact	intact	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	soluble	soluble	JJ	JJ	_	19	amod	_	_
19	preparations	preparation	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	T3SO4	t3so4	NN	NN	_	7	nsubj	_	_
4	was	be	VBD	VBD	_	7	cop	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	directly	directly	RB	RB	_	7	advmod	_	_
7	thyromimetic	thyromimetic	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	14	case	_	_
9	either	either	CC	CC	_	14	cc:preconj	_	_
10	an	a	DT	DT	_	14	det	_	_
11	isolated	isolate	VBN	VBN	_	14	amod	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	system	system	NN	NN	_	7	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	a	a	DT	DT	_	19	det	_	_
17	pituitary	pituitary	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	system	system	NN	NN	_	14	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	which	which	WDT	WDT	_	25	nmod	_	_
22	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	occupancy	occupancy	NN	NN	_	25	nsubj	_	_
25	correlates	correlate	VBZ	VBZ	_	14	acl:relcl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	GH	gh	NN	NN	_	28	compound	_	_
28	synthesis	synthesis	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Thyroid	thyroid	NN	NN	_	2	compound	_	_
2	hormones	hormone	NNS	NNS	_	3	nsubj	_	_
3	inhibit	inhibit	VBP	VBP	_	0	root	_	_
4	-LSB-3H-RSB-glycosaminoglycan	-lsb-3h-rsb-glycosaminoglycan	NN	NN	_	5	compound	_	_
5	synthesis	synthesis	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	10	case	_	_
7	cultured	culture	VBN	VBN	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	dermal	dermal	JJ	JJ	_	10	amod	_	_
10	fibroblasts	fibroblast	NNS	NNS	_	3	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	T3SO4	t3so4	NN	NN	_	14	nsubj	_	_
14	displayed	display	VBN	VBN	_	3	conj	_	_
15	about	about	IN	IN	_	16	advmod	_	_
16	0.5	0.5	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	14	dobj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activity	activity	NN	NN	_	17	dep	_	_
20	of	of	IN	IN	_	21	case	_	_
21	T3	t3	NN	NN	_	17	nmod	_	_
22	at	at	IN	IN	_	24	case	_	_
23	72	72	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	fibroblasts	fibroblast	NNS	NNS	_	3	nsubj	_	_
3	contained	contain	VBD	VBD	_	0	root	_	_
4	roughly	roughly	RB	RB	_	7	advmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	same	same	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	microsomal	microsomal	JJ	JJ	_	12	amod	_	_
10	p-nitrophenyl	p-nitrophenyl	NN	NN	_	12	compound	_	_
11	sulfatase	sulfatase	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	as	as	IN	IN	_	14	case	_	_
14	that	that	DT	DT	_	7	nmod	_	_
15	previously	previously	RB	RB	_	16	advmod	_	_
16	observed	observe	VBN	VBN	_	14	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	hepatic	hepatic	JJ	JJ	_	19	amod	_	_
19	microsomes	microsome	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Propylthiouracil	propylthiouracil	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	50	50	CD	CD	_	4	nummod	_	_
4	mumol/L	mumol/l	NN	NN	_	1	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	affect	affect	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	action	action	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	T3SO4	t3so4	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	deiodination	deiodination	NN	NN	_	19	nsubj	_	_
17	was	be	VBD	VBD	_	19	cop	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	important	important	JJ	JJ	_	14	ccomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	this	this	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	T3SO4	t3so4	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	T3SO4	t3so4	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	4	ccomp	_	_
7	no	no	DT	DT	_	10	neg	_	_
8	intrinsic	intrinsic	JJ	JJ	_	10	amod	_	_
9	biological	biological	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	,	,	,	,	_	6	punct	_	_
14	under	under	IN	IN	_	16	case	_	_
15	certain	certain	JJ	JJ	_	16	amod	_	_
16	circumstances	circumstance	NNS	NNS	_	20	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	reactivated	reactivate	VBN	VBN	_	6	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	desulfation	desulfation	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	contains	contain	VBZ	VBZ	_	0	root	_	_
8	Fos	fos	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Jun	jun	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	NF-AT	nf-at	NN	NN	_	10	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	ref.	ref.	NN	NN	_	4	appos	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	stimulated	stimulate	VBN	VBN	_	13	acl	_	_
15	through	through	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	T-cell	t-cell	NN	NN	_	18	dep	_	_
18	receptor/CD3	receptor/cd3	NN	NN	_	19	amod	_	_
19	complex	complex	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	required	require	VBN	VBN	_	10	conj	_	_
24	for	for	IN	IN	_	30	case	_	_
25	interleukin-2	interleukin-2	NN	NN	_	30	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IL-2	il-2	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	induction	induction	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	NF-AT	nf-at	NN	NN	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	cloned	clone	VBN	VBN	_	11	advcl	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	purified	purify	VBN	VBN	_	6	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	there	there	EX	EX	_	11	expl	_	_
11	is	be	VBZ	VBZ	_	0	root	_	_
12	evidence	evidence	NN	NN	_	11	nsubj	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	it	it	PRP	PRP	_	18	nsubj	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	a	a	DT	DT	_	18	det	_	_
17	major	major	JJ	JJ	_	18	amod	_	_
18	target	target	NN	NN	_	12	ccomp	_	_
19	for	for	IN	IN	_	20	case	_	_
20	immunosuppression	immunosuppression	NN	NN	_	18	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	cyclosporin	cyclosporin	NN	NN	_	23	compound	_	_
23	A	a	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CsA	csa	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	FK506	fk506	NN	NN	_	23	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	refs	ref	NNS	NNS	_	28	appos	_	_
31	2-7	2-7	CD	CD	_	30	dep	_	_
32	)	)	-RRB-	-RRB-	_	30	punct	_	_
33	.	.	.	.	_	11	punct	_	_

1	NF-AT	nf-at	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	require	require	VB	VB	_	0	root	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	activation-dependent	activation-dependent	JJ	JJ	_	7	amod	_	_
7	events	event	NNS	NNS	_	4	dobj	_	_
8	:	:	:	:	_	7	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CsA-sensitive	csa-sensitive	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	7	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	pre-existing	pre-existing	JJ	JJ	_	15	amod	_	_
15	component	component	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CsA-resistant	csa-resistant	JJ	JJ	_	19	amod	_	_
19	synthesis	synthesis	NN	NN	_	11	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	component	component	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	newly	newly	RB	RB	_	7	advmod	_	_
7	synthesized	synthesize	VBN	VBN	_	9	amod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	16	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-AT	nf-at	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	AP-1	ap-1	NN	NN	_	3	ccomp	_	_
17	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	inducible	inducible	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	form	form	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-AT	nf-at	NN	NN	_	7	nmod	_	_
10	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
11	Fos	fos	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Jun	jun	NN	NN	_	11	conj	_	_
14	proteins	protein	NNS	NNS	_	10	dobj	_	_
15	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	identify	identify	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	pre-existing	pre-existing	JJ	JJ	_	8	amod	_	_
7	NF-AT-binding	nf-at-binding	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	4	dobj	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	present	present	JJ	JJ	_	8	acl:relcl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	hypotonic	hypotonic	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	unstimulated	unstimulated	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	On	on	IN	IN	_	10	case	_	_
2	the	the	DT	DT	_	10	dep	_	_
3	basis	basis	NN	NN	_	10	dep	_	_
4	of	of	IN	IN	_	10	case	_	_
5	binding	binding	NN	NN	_	10	compound	_	_
6	,	,	,	,	_	5	punct	_	_
7	reconstitution	reconstitution	NN	NN	_	5	conj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	cotransfection	cotransfection	NN	NN	_	5	conj	_	_
10	experiments	experiment	NNS	NNS	_	13	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	propose	propose	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	activation	activation	NN	NN	_	18	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-AT	nf-at	NN	NN	_	15	nmod	_	_
18	occurs	occur	VBZ	VBZ	_	13	ccomp	_	_
19	in	in	IN	IN	_	23	case	_	_
20	at	at	IN	IN	_	21	case	_	_
21	least	least	JJS	JJS	_	22	nmod:npmod	_	_
22	two	two	CD	CD	_	23	nummod	_	_
23	stages	stage	NNS	NNS	_	18	nmod	_	_
24	:	:	:	:	_	23	punct	_	_
25	a	a	DT	DT	_	27	det	_	_
26	CsA-sensitive	csa-sensitive	JJ	JJ	_	27	amod	_	_
27	stage	stage	NN	NN	_	23	dep	_	_
28	involving	involve	VBG	VBG	_	27	acl	_	_
29	modification	modification	NN	NN	_	28	dobj	_	_
30	and/or	and/or	CC	CC	_	29	cc	_	_
31	translocation	translocation	NN	NN	_	29	conj	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	pre-existing	pre-existing	JJ	JJ	_	36	amod	_	_
35	NF-AT	nf-at	NN	NN	_	36	compound	_	_
36	complex	complex	NN	NN	_	29	nmod	_	_
37	,	,	,	,	_	27	punct	_	_
38	and	and	CC	CC	_	27	cc	_	_
39	a	a	DT	DT	_	41	det	_	_
40	CsA-insensitive	csa-insensitive	JJ	JJ	_	41	amod	_	_
41	stage	stage	NN	NN	_	27	conj	_	_
42	involving	involve	VBG	VBG	_	41	acl	_	_
43	the	the	DT	DT	_	44	det	_	_
44	addition	addition	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	51	case	_	_
46	newly	newly	RB	RB	_	47	advmod	_	_
47	synthesized	synthesize	VBN	VBN	_	51	amod	_	_
48	Fos	fos	NN	NN	_	51	compound	_	_
49	or	or	CC	CC	_	48	cc	_	_
50	Fos/Jun	fos/jun	NN	NN	_	48	conj	_	_
51	proteins	protein	NNS	NNS	_	44	nmod	_	_
52	to	to	TO	TO	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	pre-existing	pre-existing	JJ	JJ	_	55	amod	_	_
55	complex	complex	NN	NN	_	44	nmod	_	_
56	.	.	.	.	_	13	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	2	nsubj	_	_
2	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	antiviral	antiviral	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	interferon-stimulated	interferon-stimulated	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	5	nmod	_	_
12	induced	induce	VBN	VBN	_	5	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	interferon-alpha	interferon-alpha	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	U937	u937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Binding	binding	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	type	type	NN	NN	_	5	compound	_	_
4	I	i	CD	CD	_	5	nummod	_	_
5	interferon	interferon	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	to	to	TO	TO	_	11	case	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	receptors	receptor	NNS	NNS	_	1	nmod	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	rapid	rapid	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	independent	independent	JJ	JJ	_	17	amod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	synthesis	synthesis	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	17	punct	_	_
24	of	of	IN	IN	_	26	case	_	_
25	IFN-alpha-stimulated	ifn-alpha-stimulated	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	17	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	ISGs	isg	NNS	NNS	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	in	in	IN	IN	_	32	case	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	fibroblasts	fibroblast	NNS	NNS	_	26	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	HeLa	hela	NN	NN	_	38	compound	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	Daudi	daudi	NN	NN	_	34	conj	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	32	conj	_	_
39	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ISGF3	isgf3	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	IFN-stimulated	ifn-stimulated	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	4	appos	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	)	)	-RRB-	-RRB-	_	8	punct	_	_
11	to	to	TO	TO	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	conserved	conserve	VBN	VBN	_	16	amod	_	_
14	IFN-stimulated	ifn-stimulated	JJ	JJ	_	16	amod	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	2	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ISRE	isre	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	results	result	VBZ	VBZ	_	0	root	_	_
21	in	in	IN	IN	_	23	case	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	composed	compose	VBN	VBN	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	ISGF3	isgf3	NN	NN	_	11	compound	_	_
11	gamma	gamma	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	8	punct	_	_
14	which	which	WDT	WDT	_	17	nsubj	_	_
15	normally	normally	RB	RB	_	17	advmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	present	present	JJ	JJ	_	8	acl:relcl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cytoplasm	cytoplasm	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	other	other	JJ	JJ	_	25	amod	_	_
24	IFN-alpha-activated	ifn-alpha-activated	JJ	JJ	_	25	amod	_	_
25	proteins	protein	NNS	NNS	_	8	conj	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	preexist	preexist	VBP	VBP	_	25	acl:relcl	_	_
28	as	as	IN	IN	_	31	case	_	_
29	latent	latent	JJ	JJ	_	31	amod	_	_
30	cytoplasmic	cytoplasmic	JJ	JJ	_	31	amod	_	_
31	precursors	precursor	NNS	NNS	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	ISGF3	isgf3	NN	NN	_	34	compound	_	_
34	alpha	alpha	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	ISG	isg	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	13	nsubj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
10	U937	u937	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	6	nmod	_	_
13	differs	differ	VBZ	VBZ	_	3	ccomp	_	_
14	from	from	IN	IN	_	17	case	_	_
15	most	most	JJS	JJS	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	nmod	_	_
18	previously	previously	RB	RB	_	19	advmod	_	_
19	examined	examine	VBN	VBN	_	17	acl	_	_
20	.	.	.	.	_	3	punct	_	_

1	U937	u937	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	type	type	NN	NN	_	11	compound	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	type	type	NN	NN	_	5	conj	_	_
9	II	ii	CD	CD	_	8	nummod	_	_
10	IFN	ifn	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	3	dobj	_	_
12	,	,	,	,	_	3	punct	_	_
13	but	but	CC	CC	_	3	cc	_	_
14	only	only	RB	RB	_	15	advmod	_	_
15	IFN-alpha	ifn-alpha	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	capable	capable	JJ	JJ	_	3	conj	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	inducing	induce	VBG	VBG	_	17	advcl	_	_
20	antiviral	antiviral	JJ	JJ	_	21	amod	_	_
21	protection	protection	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	4	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
4	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IFN-alpha-induced	ifn-alpha-induced	JJ	JJ	_	7	amod	_	_
7	protection	protection	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	4	punct	_	_
9	but	but	CC	CC	_	4	cc	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	14	nsubj	_	_
11	alone	alone	RB	RB	_	10	advmod	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	have	have	VB	VB	_	4	conj	_	_
15	any	any	DT	DT	_	17	det	_	_
16	antiviral	antiviral	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	4	punct	_	_

1	ISG15	isg15	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	accumulation	accumulation	NN	NN	_	9	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	U937	u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	detectable	detectable	JJ	JJ	_	0	root	_	_
10	before	before	IN	IN	_	12	case	_	_
11	6	6	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IFN-alpha	ifn-alpha	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	peaks	peak	VBZ	VBZ	_	9	conj	_	_
18	at	at	IN	IN	_	20	case	_	_
19	24	24	CD	CD	_	20	nummod	_	_
20	h	h	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	requires	require	VBZ	VBZ	_	9	conj	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	synthesis	synthesis	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	9	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	IFN-gamma	ifn-gamma	NN	NN	_	6	nsubj	_	_
3	alone	alone	RB	RB	_	2	advmod	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	induce	induce	VB	VB	_	13	advcl	_	_
7	ISG	isg	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	13	punct	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	11	compound	_	_
11	pretreatment	pretreatment	NN	NN	_	13	nsubj	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	increases	increase	VBZ	VBZ	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	hastens	hasten	VBZ	VBZ	_	13	conj	_	_
16	ISG	isg	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	13	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	induction	induction	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	13	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	extracts	extract	NNS	NNS	_	16	nsubj	_	_
3	assayed	assay	VBN	VBN	_	2	acl	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	ISRE	isre	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	15	case	_	_
12	electrophoretic	electrophoretic	JJ	JJ	_	15	amod	_	_
13	mobility	mobility	NN	NN	_	15	compound	_	_
14	shift	shift	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	3	nmod	_	_
16	show	show	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	ISGF3	isgf3	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	induced	induce	VBN	VBN	_	16	ccomp	_	_
21	by	by	IN	IN	_	22	case	_	_
22	IFN-alpha	ifn-alpha	NN	NN	_	20	nmod	_	_
23	within	within	IN	IN	_	25	case	_	_
24	6	6	CD	CD	_	25	nummod	_	_
25	h	h	NN	NN	_	20	nmod	_	_
26	from	from	IN	IN	_	29	case	_	_
27	undetectable	undetectable	JJ	JJ	_	29	amod	_	_
28	basal	basal	JJ	JJ	_	29	amod	_	_
29	levels	level	NNS	NNS	_	20	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	untreated	untreated	JJ	JJ	_	33	amod	_	_
32	U937	u937	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	20	nmod	_	_
34	.	.	.	.	_	16	punct	_	_

1	Activation	activation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	ISGF3	isgf3	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	latent	latent	JJ	JJ	_	8	amod	_	_
8	component	component	NN	NN	_	4	appos	_	_
9	of	of	IN	IN	_	10	case	_	_
10	ISGF3	isgf3	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	occurs	occur	VBZ	VBZ	_	0	root	_	_
13	rapidly	rapidly	RB	RB	_	12	advmod	_	_
14	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	9	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	ISGF3	isgf3	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	ultimately	ultimately	RB	RB	_	9	advmod	_	_
9	correlates	correlate	VBZ	VBZ	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	accumulation	accumulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	ISGF3	isgf3	NN	NN	_	15	compound	_	_
15	gamma	gamma	NN	NN	_	12	nmod	_	_
16	induced	induce	VBN	VBN	_	12	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	IFN-alpha	ifn-alpha	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	action	action	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cyclosporin	cyclosporin	NN	NN	_	7	compound	_	_
7	A	a	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	FK506	fk506	NN	NN	_	7	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	CsA	csa	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	FK506	fk506	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	powerful	powerful	JJ	JJ	_	6	amod	_	_
6	suppressors	suppressor	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	system	system	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	most	most	RBS	RBS	_	13	advmod	_	_
13	notably	notably	RB	RB	_	16	advmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	act	act	VBP	VBP	_	0	root	_	_
3	at	at	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	point	point	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	5	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	lies	lie	VBZ	VBZ	_	5	acl:relcl	_	_
10	between	between	IN	IN	_	12	case	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	ligation	ligation	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transcription	transcription	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	early	early	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Stuart	Stuart	NNP	NNP	_	4	compound	_	_
4	Schreiber	Schreiber	NNP	NNP	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Gerald	Gerald	NNP	NNP	_	7	compound	_	_
7	Crabtree	Crabtree	NNP	NNP	_	4	conj	_	_
8	review	review	VBP	VBP	_	0	root	_	_
9	recent	recent	JJ	JJ	_	10	amod	_	_
10	findings	finding	NNS	NNS	_	8	dobj	_	_
11	that	that	WDT	WDT	_	16	dep	_	_
12	indicate	indicate	VBP	VBP	_	16	dep	_	_
13	CsA	csa	NN	NN	_	16	nsubj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	FK506	fk506	NN	NN	_	13	conj	_	_
16	operate	operate	VBP	VBP	_	10	acl:relcl	_	_
17	as	as	IN	IN	_	18	case	_	_
18	prodrugs	prodrug	NNS	NNS	_	16	nmod	_	_
19	:	:	:	:	_	8	punct	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	bind	bind	VBP	VBP	_	8	parataxis	_	_
22	endogenous	endogenous	JJ	JJ	_	24	amod	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	receptors	receptor	NNS	NNS	_	21	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	the	the	DT	DT	_	27	det	_	_
27	immunophilins	immunophilin	NNS	NNS	_	24	appos	_	_
28	,	,	,	,	_	21	punct	_	_
29	and	and	CC	CC	_	21	cc	_	_
30	the	the	DT	DT	_	32	det	_	_
31	resulting	result	VBG	VBG	_	32	amod	_	_
32	complex	complex	NN	NN	_	33	nsubj	_	_
33	targets	target	VBZ	VBZ	_	21	conj	_	_
34	the	the	DT	DT	_	36	det	_	_
35	protein	protein	NN	NN	_	36	compound	_	_
36	phosphatase	phosphatase	NN	NN	_	33	dobj	_	_
37	,	,	,	,	_	36	punct	_	_
38	calcineurin	calcineurin	NN	NN	_	36	appos	_	_
39	,	,	,	,	_	36	punct	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	exert	exert	VB	VB	_	33	advcl	_	_
42	the	the	DT	DT	_	44	det	_	_
43	immunosuppressive	immunosuppressive	JJ	JJ	_	44	amod	_	_
44	effect	effect	NN	NN	_	41	dobj	_	_
45	.	.	.	.	_	21	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Plasma	plasma	NN	NN	_	4	compound	_	_
3	cortisol	cortisol	NN	NN	_	4	compound	_	_
4	concentration	concentration	NN	NN	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	content	content	NN	NN	_	4	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	4	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	deficiency-cold	deficiency-cold	JJ	JJ	_	18	amod	_	_
16	vs	vs	CC	CC	_	15	cc	_	_
17	deficiency-heat	deficiency-heat	JJ	JJ	_	15	conj	_	_
18	syndromes	syndrome	NNS	NNS	_	13	nmod	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	4	punct	_	_

1	Plasma	plasma	NN	NN	_	3	compound	_	_
2	cortisol	cortisol	NN	NN	_	3	compound	_	_
3	concentration	concentration	NN	NN	_	15	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	leukocyte	leukocyte	NN	NN	_	7	compound	_	_
7	content	content	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	GCR	gcr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	were	be	VBD	VBD	_	15	aux	_	_
15	assayed	assay	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	20	20	CD	CD	_	18	nummod	_	_
18	patients	patient	NNS	NNS	_	15	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	deficiency	deficiency	NN	NN	_	21	compound	_	_
21	syndromes	syndrome	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	10	10	CD	CD	_	18	appos	_	_
24	cold	cold	JJ	JJ	_	23	amod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	property	property	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	deficiency-cold	deficiency-cold	JJ	JJ	_	24	dep	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	23	punct	_	_
31	the	the	DT	DT	_	33	det	_	_
32	other	other	JJ	JJ	_	33	amod	_	_
33	10	10	CD	CD	_	23	appos	_	_
34	hot	hot	JJ	JJ	_	33	amod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	property	property	NN	NN	_	34	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	deficiency-heat	deficiency-heat	JJ	JJ	_	34	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	,	,	,	,	_	15	punct	_	_
41	and	and	CC	CC	_	15	cc	_	_
42	also	also	RB	RB	_	15	advmod	_	_
43	in	in	IN	IN	_	46	case	_	_
44	10	10	CD	CD	_	46	nummod	_	_
45	healthy	healthy	JJ	JJ	_	46	amod	_	_
46	individuals	individual	NNS	NNS	_	15	dep	_	_
47	as	as	IN	IN	_	49	case	_	_
48	normal	normal	JJ	JJ	_	49	amod	_	_
49	control	control	NN	NN	_	46	nmod	_	_
50	for	for	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	purpose	purpose	NN	NN	_	15	nmod	_	_
53	of	of	IN	IN	_	54	mark	_	_
54	investigating	investigate	VBG	VBG	_	52	acl	_	_
55	the	the	DT	DT	_	56	det	_	_
56	nature	nature	NN	NN	_	54	dobj	_	_
57	of	of	IN	IN	_	61	case	_	_
58	cold	cold	NN	NN	_	61	amod	_	_
59	and	and	CC	CC	_	58	cc	_	_
60	heat	heat	NN	NN	_	58	conj	_	_
61	syndromes	syndrome	NNS	NNS	_	56	nmod	_	_
62	.	.	.	.	_	15	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	result	result	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cases	case	NNS	NNS	_	13	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	deficiency-cold	deficiency-cold	JJ	JJ	_	9	amod	_	_
9	syndrome	syndrome	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	DCS	dcs	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	concentration	concentration	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	plasma	plasma	NN	NN	_	19	compound	_	_
19	cortisol	cortisol	NN	NN	_	16	nmod	_	_
20	but	but	CC	CC	_	16	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	lowered	lowered	JJ	JJ	_	23	amod	_	_
23	content	content	NN	NN	_	16	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	GCR	gcr	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	leukocytes	leukocyte	NNS	NNS	_	25	nmod	_	_
28	when	when	WRB	WRB	_	29	advmod	_	_
29	compared	compare	VBN	VBN	_	13	advcl	_	_
30	with	with	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	normal	normal	JJ	JJ	_	33	amod	_	_
33	control	control	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	38	punct	_	_
35	P	p	NN	NN	_	38	dep	_	_
36	less	less	JJR	JJR	_	38	advmod	_	_
37	than	than	IN	IN	_	36	mwe	_	_
38	0.05	0.05	CD	CD	_	33	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	;	;	:	:	_	13	punct	_	_
41	the	the	DT	DT	_	42	det	_	_
42	cases	case	NNS	NNS	_	49	nsubj	_	_
43	of	of	IN	IN	_	45	case	_	_
44	deficiency-heat	deficiency-heat	JJ	JJ	_	45	amod	_	_
45	syndrome	syndrome	NN	NN	_	42	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	DHS	dhs	NN	NN	_	45	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	had	have	VBD	VBD	_	13	parataxis	_	_
50	a	a	DT	DT	_	52	det	_	_
51	higher	higher	JJR	JJR	_	52	amod	_	_
52	concentration	concentration	NN	NN	_	49	dobj	_	_
53	of	of	IN	IN	_	55	case	_	_
54	plasma	plasma	NN	NN	_	55	compound	_	_
55	cortisol	cortisol	NN	NN	_	52	nmod	_	_
56	than	than	IN	IN	_	59	case	_	_
57	the	the	DT	DT	_	59	det	_	_
58	normal	normal	JJ	JJ	_	59	amod	_	_
59	control	control	NN	NN	_	52	nmod	_	_
60	(	(	-LRB-	-LRB-	_	64	punct	_	_
61	P	p	NN	NN	_	64	dep	_	_
62	less	less	JJR	JJR	_	64	advmod	_	_
63	than	than	IN	IN	_	62	mwe	_	_
64	0.05	0.05	CD	CD	_	59	dep	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	and	and	CC	CC	_	52	cc	_	_
67	a	a	DT	DT	_	70	det	_	_
68	slightly	slightly	RB	RB	_	69	advmod	_	_
69	higher	higher	JJR	JJR	_	70	amod	_	_
70	content	content	NN	NN	_	52	conj	_	_
71	of	of	IN	IN	_	72	case	_	_
72	GCR	gcr	NN	NN	_	70	nmod	_	_
73	in	in	IN	IN	_	74	case	_	_
74	leukocytes	leukocyte	NNS	NNS	_	70	nmod	_	_
75	.	.	.	.	_	49	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	DCS	dcs	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	characterized	characterize	VBN	VBN	_	3	ccomp	_	_
9	by	by	IN	IN	_	12	case	_	_
10	diminished	diminish	VBN	VBN	_	12	amod	_	_
11	biological	biological	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	adrenocortical	adrenocortical	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	while	while	IN	IN	_	8	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	DHS	dhs	NN	NN	_	8	parataxis	_	_
20	,	,	,	,	_	19	punct	_	_
21	by	by	IN	IN	_	24	case	_	_
22	augmented	augmented	JJ	JJ	_	24	amod	_	_
23	biological	biological	JJ	JJ	_	24	amod	_	_
24	effects	effect	NNS	NNS	_	19	dep	_	_
25	of	of	IN	IN	_	27	case	_	_
26	adrenocortical	adrenocortical	JJ	JJ	_	27	amod	_	_
27	activity	activity	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Specific	specific	JJ	JJ	_	4	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	subunits	subunit	NNS	NNS	_	5	nsubj	_	_
5	act	act	VBP	VBP	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	concert	concert	NN	NN	_	9	dep	_	_
8	with	with	IN	IN	_	9	case	_	_
9	Tat	tat	NN	NN	_	5	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	stimulate	stimulate	VB	VB	_	5	xcomp	_	_
12	human	human	JJ	JJ	_	17	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
14	virus	virus	NN	NN	_	17	compound	_	_
15	type	type	NN	NN	_	17	compound	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	transcription	transcription	NN	NN	_	11	dobj	_	_
18	.	.	.	.	_	5	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	0	root	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	functions	function	VBZ	VBZ	_	6	acl:relcl	_	_
9	in	in	IN	IN	_	15	case	_	_
10	concert	concert	NN	NN	_	15	dep	_	_
11	with	with	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	tat-I	tat-i	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	product	product	NN	NN	_	8	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	stimulate	stimulate	VB	VB	_	8	xcomp	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	20	compound	_	_
20	virus	virus	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	HIV	hiv	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	transcription	transcription	NN	NN	_	17	dobj	_	_
25	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	18	advcl	_	_
3	whether	whether	IN	IN	_	11	mark	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	members	member	NNS	NNS	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	family	family	NN	NN	_	5	nmod	_	_
11	contribute	contribute	VBP	VBP	_	2	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	effect	effect	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	examined	examine	VBN	VBN	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	abilities	ability	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	different	different	JJ	JJ	_	25	amod	_	_
23	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	subunits	subunit	NNS	NNS	_	20	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	act	act	VB	VB	_	20	acl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	Tat-I	tat-i	NN	NN	_	27	nmod	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	stimulate	stimulate	VB	VB	_	27	xcomp	_	_
32	transcription	transcription	NN	NN	_	31	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	HIV	hiv	NN	NN	_	32	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	Jurkat	jurkat	NN	NN	_	38	compound	_	_
37	T-leukemia	t-leukemia	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	12	det	_	_
6	p49	p49	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	12	punct	_	_
8	100	100	CD	CD	_	12	nummod	_	_
9	)	)	-RRB-	-RRB-	_	12	punct	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	subunit	subunit	NN	NN	_	19	nsubj	_	_
13	,	,	,	,	_	19	punct	_	_
14	together	together	RB	RB	_	16	advmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	p65	p65	NN	NN	_	19	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	act	act	VB	VB	_	3	ccomp	_	_
20	in	in	IN	IN	_	23	case	_	_
21	concert	concert	NN	NN	_	23	dep	_	_
22	with	with	IN	IN	_	23	case	_	_
23	Tat-I	tat-i	NN	NN	_	19	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	stimulate	stimulate	VB	VB	_	19	xcomp	_	_
26	the	the	DT	DT	_	27	det	_	_
27	expression	expression	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	HIV-CAT	hiv-cat	NN	NN	_	30	compound	_	_
30	plasmid	plasmid	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Little	little	JJ	JJ	_	2	amod	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	50-kDa	50-kda	JJ	JJ	_	7	amod	_	_
7	forms	form	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	p105	p105	NN	NN	_	11	compound	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	7	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	rel	rel	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	4	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	combination	combination	NN	NN	_	4	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	p65	p65	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	full-length	full-length	JJ	JJ	_	21	amod	_	_
21	c-rel	c-rel	NN	NN	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	which	which	WDT	WDT	_	26	nsubj	_	_
24	do	do	VBP	VBP	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	stimulate	stimulate	VB	VB	_	18	acl:relcl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	HIV	hiv	NN	NN	_	29	compound	_	_
29	enhancer	enhancer	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	combination	combination	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p49	p49	NN	NN	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	8	punct	_	_
10	100	100	CD	CD	_	8	nummod	_	_
11	)	)	-RRB-	-RRB-	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	p65	p65	NN	NN	_	15	compound	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	8	conj	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	act	act	VB	VB	_	3	ccomp	_	_
18	in	in	IN	IN	_	24	case	_	_
19	concert	concert	NN	NN	_	24	dep	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	tat-I	tat-i	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	product	product	NN	NN	_	17	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	stimulate	stimulate	VB	VB	_	17	xcomp	_	_
27	the	the	DT	DT	_	28	det	_	_
28	synthesis	synthesis	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	HIV	hiv	NN	NN	_	31	compound	_	_
31	RNA	rna	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
6	virus	virus	NN	NN	_	9	compound	_	_
7	type	type	NN	NN	_	9	compound	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	enhancer	enhancer	NN	NN	_	1	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	on	on	IN	IN	_	14	case	_	_
14	NFAT-1	nfat-1	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	putative	putative	JJ	JJ	_	7	amod	_	_
6	NFAT-1	nfat-1	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	human	human	JJ	JJ	_	15	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	15	compound	_	_
12	virus	virus	NN	NN	_	15	compound	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	enhancer	enhancer	NN	NN	_	2	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	analyzed	analyze	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	by	by	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	T-cell	t-cell	NN	NN	_	6	compound	_	_
5	antigen	antigen	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	1	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	minimal	minimal	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	8	conj	_	_
15	by	by	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	putative	putative	JJ	JJ	_	4	amod	_	_
3	NFAT-1	nfat-1	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	response	response	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	anti-CD3	anti-cd3	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	to	to	TO	TO	_	15	case	_	_
15	mitogens	mitogen	NNS	NNS	_	12	conj	_	_
16	in	in	IN	IN	_	24	case	_	_
17	T-cell	t-cell	NN	NN	_	24	compound	_	_
18	,	,	,	,	_	17	punct	_	_
19	B-cell	b-cell	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	or	or	CC	CC	_	17	cc	_	_
22	monocyte/macrophage	monocyte/macrophage	NN	NN	_	23	compound	_	_
23	leukemia	leukemia	NN	NN	_	17	conj	_	_
24	lines	line	NNS	NNS	_	10	nmod	_	_
25	,	,	,	,	_	7	punct	_	_
26	nor	nor	CC	CC	_	7	cc	_	_
27	is	be	VBZ	VBZ	_	7	conj	_	_
28	it	it	PRP	PRP	_	27	nsubj	_	_
29	a	a	DT	DT	_	33	det	_	_
30	cis-acting	cis-acting	JJ	JJ	_	33	amod	_	_
31	negative	negative	JJ	JJ	_	33	amod	_	_
32	regulatory	regulatory	JJ	JJ	_	33	amod	_	_
33	element	element	NN	NN	_	27	dep	_	_
34	.	.	.	.	_	7	punct	_	_

1	Protein	protein	NN	NN	_	4	compound	_	_
2	kinase	kinase	NN	NN	_	4	compound	_	_
3	C	c	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	protooncogene	protooncogene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	conj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	differentiation/retrodifferentiation	differentiation/retrodifferentiation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	U-937	u-937	NN	NN	_	14	compound	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	U-937	u-937	NN	NN	_	4	compound	_	_
3	leukemia	leukemia	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	differentiate	differentiate	VBP	VBP	_	0	root	_	_
6	along	along	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	lineage	lineage	NN	NN	_	5	nmod	_	_
10	following	follow	VBG	VBG	_	12	case	_	_
11	3-day	3-day	JJ	JJ	_	12	amod	_	_
12	exposures	exposure	NNS	NNS	_	5	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TPA	tpa	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	differentiation	differentiation	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	adherence	adherence	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	loss	loss	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	proliferation	proliferation	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	as	as	RB	RB	_	8	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	expression/repression	expression/repression	NN	NN	_	8	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	differentiation-associated	differentiation-associated	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Long	long	JJ	JJ	_	2	dep	_	_
2	term	term	NN	NN	_	3	amod	_	_
3	culture	culture	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	TPA-differentiated	tpa-differentiated	JJ	JJ	_	7	amod	_	_
6	U-937	u-937	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	dep	_	_
10	absence	absence	NN	NN	_	13	dep	_	_
11	of	of	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	ester	ester	NN	NN	_	3	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	32-36	32-36	CD	CD	_	16	nummod	_	_
16	days	day	NNS	NNS	_	3	nmod	_	_
17	resulted	result	VBD	VBD	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	process	process	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	retrodifferentiation	retrodifferentiation	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	retrodifferentiated	retrodifferentiate	VBN	VBN	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	detached	detach	VBD	VBD	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	substrate	substrate	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	reinitiated	reinitiate	VBD	VBD	_	4	conj	_	_
10	proliferation	proliferation	NN	NN	_	9	dobj	_	_
11	.	.	.	.	_	4	punct	_	_

1	Other	other	JJ	JJ	_	3	amod	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	parameters	parameter	NNS	NNS	_	17	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	such	such	JJ	JJ	_	8	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	glycosidase	glycosidase	NN	NN	_	8	compound	_	_
8	activities	activity	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	release	release	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	filament	filament	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	8	conj	_	_
16	,	,	,	,	_	3	punct	_	_
17	returned	return	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	19	case	_	_
19	levels	level	NNS	NNS	_	17	nmod	_	_
20	similar	similar	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	observed	observe	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	uninduced	uninduced	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Treatment	treatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	U-937	u-937	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	TPA	tpa	NN	NN	_	1	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	rapid	rapid	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PKC	pkc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	from	from	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytosol	cytosol	NN	NN	_	11	nmod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	membrane	membrane	NN	NN	_	25	compound	_	_
25	fractions	fraction	NNS	NNS	_	11	nmod	_	_
26	within	within	IN	IN	_	28	case	_	_
27	2-8	2-8	CD	CD	_	28	nummod	_	_
28	min	min	NN	NN	_	11	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	membrane-associated	membrane-associated	JJ	JJ	_	6	amod	_	_
5	PKC	pkc	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	persisted	persist	VBD	VBD	_	0	root	_	_
8	until	until	IN	IN	_	10	case	_	_
9	17-29	17-29	CD	CD	_	10	nummod	_	_
10	days	day	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	longer	longer	JJR	JJR	_	4	amod	_	_
4	periods	period	NNS	NNS	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	incubation	incubation	NN	NN	_	4	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	return	return	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	distribution	distribution	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	PKC	pkc	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	control	control	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PKC	pkc	NN	NN	_	1	nmod	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	implicated	implicate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	certain	certain	JJ	JJ	_	15	amod	_	_
12	immediate	immediate	JJ	JJ	_	15	amod	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	response	response	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	present	present	JJ	JJ	_	21	amod	_	_
21	studies	study	NNS	NNS	_	25	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	TPA	tpa	NN	NN	_	25	nsubj	_	_
24	rapidly	rapidly	RB	RB	_	25	advmod	_	_
25	induced	induce	VBD	VBD	_	6	conj	_	_
26	c-fos	c-fos	NN	NN	_	30	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	c-jun	c-jun	NN	NN	_	26	conj	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	25	dobj	_	_
31	.	.	.	.	_	6	punct	_	_

1	Levels	level	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	c-fos	c-fos	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	c-jun	c-jun	NN	NN	_	3	conj	_	_
6	transcripts	transcript	NNS	NNS	_	1	nmod	_	_
7	remained	remain	VBD	VBD	_	0	root	_	_
8	elevated	elevated	JJ	JJ	_	7	xcomp	_	_
9	during	during	IN	IN	_	10	case	_	_
10	periods	period	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	PKC	pkc	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	also	also	RB	RB	_	7	advmod	_	_
16	returned	return	VBD	VBD	_	7	dep	_	_
17	to	to	TO	TO	_	18	case	_	_
18	levels	level	NNS	NNS	_	16	nmod	_	_
19	observed	observe	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	control	control	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	30-36	30-36	CD	CD	_	25	nummod	_	_
25	days	day	NNS	NNS	_	19	nmod	_	_
26	,	,	,	,	_	7	punct	_	_
27	when	when	WRB	WRB	_	30	advmod	_	_
28	the	the	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	30	nsubj	_	_
30	entered	enter	VBD	VBD	_	7	advcl	_	_
31	retrodifferentiation	retrodifferentiation	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	7	punct	_	_

1	Staurosporine	staurosporine	NN	NN	_	10	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	nonspecific	nonspecific	JJ	JJ	_	5	amod	_	_
5	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PKC	pkc	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	partially	partially	RB	RB	_	10	advmod	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	TPA-induced	tpa-induced	JJ	JJ	_	12	amod	_	_
12	adherence	adherence	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	inhibition	inhibition	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	concomitantly	concomitantly	RB	RB	_	18	advmod	_	_
18	prevented	prevent	VBD	VBD	_	10	conj	_	_
19	TPA-induced	tpa-induced	JJ	JJ	_	24	amod	_	_
20	c-fos	c-fos	NN	NN	_	24	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	c-jun	c-jun	NN	NN	_	20	conj	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	18	dobj	_	_
25	.	.	.	.	_	10	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoter	promoter	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD19	cd19	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	target	target	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	B-cell-specific	b-cell-specific	JJ	JJ	_	15	amod	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	BSAP	bsap	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CD19	cd19	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	surface	surface	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	all	all	DT	DT	_	12	det	_	_
11	B-lymphoid	b-lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	exception	exception	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	terminally	terminally	RB	RB	_	18	advmod	_	_
18	differentiated	differentiate	VBN	VBN	_	20	amod	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	and	and	CC	CC	_	5	cc	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	implicated	implicate	VBN	VBN	_	5	conj	_	_
25	as	as	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	signal-transducing	signal-transducing	JJ	JJ	_	28	amod	_	_
28	receptor	receptor	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	control	control	NN	NN	_	24	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	proliferation	proliferation	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	differentiation	differentiation	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	complete	complete	JJ	JJ	_	5	amod	_	_
5	correlation	correlation	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	pattern	pattern	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD19	cd19	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	the	the	DT	DT	_	19	det	_	_
16	B-cell-specific	b-cell-specific	JJ	JJ	_	19	amod	_	_
17	transcription	transcription	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	BSAP	bsap	NN	NN	_	9	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	large	large	JJ	JJ	_	23	amod	_	_
23	panel	panel	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	B-lymphoid	b-lymphoid	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lines	line	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	CD19	cd19	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	cloned	clone	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	BSAP-binding	bsap-binding	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	15	nsubjpass	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	mapped	map	VBN	VBN	_	7	conj	_	_
16	by	by	IN	IN	_	21	case	_	_
17	in	in	FW	FW	_	21	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	protein-DNA	protein-dna	JJ	JJ	_	21	amod	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	studies	study	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	high-affinity	high-affinity	JJ	JJ	_	7	amod	_	_
6	BSAP-binding	bsap-binding	JJ	JJ	_	7	amod	_	_
7	site	site	NN	NN	_	14	nsubj	_	_
8	instead	instead	RB	RB	_	7	cc	_	_
9	of	of	IN	IN	_	8	mwe	_	_
10	a	a	DT	DT	_	12	det	_	_
11	TATA	tata	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	7	conj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	located	located	JJ	JJ	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	-30	-30	CD	CD	_	19	nummod	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	14	nmod	_	_
20	upstream	upstream	JJ	JJ	_	19	amod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	cluster	cluster	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	heterogeneous	heterogeneous	JJ	JJ	_	28	amod	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	start	start	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	occupied	occupy	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	BSAP	bsap	NN	NN	_	6	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vivo	vivo	FW	FW	_	8	advmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	CD19-expressing	cd19-expressing	JJ	JJ	_	15	amod	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	6	nmod	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	not	not	RB	RB	_	22	neg	_	_
18	in	in	IN	IN	_	22	case	_	_
19	plasma	plasma	NN	NN	_	22	compound	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	HeLa	hela	NN	NN	_	19	conj	_	_
22	cells	cell	NNS	NNS	_	15	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	high-affinity	high-affinity	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	conserved	conserve	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	promoters	promoter	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	16	case	_	_
11	both	both	CC	CC	_	16	dep	_	_
12	human	human	JJ	JJ	_	11	dep	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	mouse	mouse	NN	NN	_	11	conj	_	_
15	CD19	cd19	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	9	nmod	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	furthermore	furthermore	RB	RB	_	20	advmod	_	_
20	shown	show	VBN	VBN	_	6	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	confer	confer	VB	VB	_	20	xcomp	_	_
23	B-cell	b-cell	NN	NN	_	24	compound	_	_
24	specificity	specificity	NN	NN	_	22	dobj	_	_
25	to	to	TO	TO	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	beta-globin	beta-globin	NN	NN	_	29	compound	_	_
28	reporter	reporter	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	22	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	transient	transient	JJ	JJ	_	33	amod	_	_
32	transfection	transfection	NN	NN	_	33	compound	_	_
33	experiments	experiment	NNS	NNS	_	22	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	BSAP	bsap	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	13	mark	_	_
8	be	be	VB	VB	_	13	cop	_	_
9	the	the	DT	DT	_	13	det	_	_
10	only	only	RB	RB	_	13	advmod	_	_
11	abundant	abundant	JJ	JJ	_	13	amod	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	6	xcomp	_	_
14	of	of	IN	IN	_	17	case	_	_
15	B-cell	b-cell	NN	NN	_	17	compound	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	extracts	extract	NNS	NNS	_	13	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	interacts	interact	VBZ	VBZ	_	13	acl:relcl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	CD19	cd19	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Together	together	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	evidence	evidence	NN	NN	_	6	nsubj	_	_
5	strongly	strongly	RB	RB	_	6	advmod	_	_
6	implicates	implicate	VBZ	VBZ	_	0	root	_	_
7	BSAP	bsap	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD19	cd19	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Reduced	reduce	VBN	VBN	_	2	amod	_	_
2	susceptibility	susceptibility	NN	NN	_	10	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	ethyl-methanesulfonate-treated	ethyl-methanesulfonate-treated	JJ	JJ	_	9	amod	_	_
8	CEM	cem	NN	NN	_	9	compound	_	_
9	subclones	subclone	NNS	NNS	_	5	nmod	_	_
10	correlates	correlate	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	blockade	blockade	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	20	case	_	_
15	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
16	protein	protein	NN	NN	_	20	compound	_	_
17	kinase	kinase	NN	NN	_	20	compound	_	_
18	C	c	NN	NN	_	20	compound	_	_
19	signaling	signaling	NN	NN	_	20	compound	_	_
20	pathway	pathway	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	described	describe	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	isolation	isolation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	chemically	chemically	RB	RB	_	8	advmod	_	_
8	induced	induce	VBN	VBN	_	10	amod	_	_
9	CEM	cem	NN	NN	_	10	compound	_	_
10	subclones	subclone	NNS	NNS	_	5	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	express	express	VBP	VBP	_	10	acl:relcl	_	_
13	CD4	cd4	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	12	dobj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	bind	bind	VBP	VBP	_	12	conj	_	_
17	soluble	soluble	JJ	JJ	_	18	amod	_	_
18	gp120	gp120	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	12	punct	_	_
20	yet	yet	RB	RB	_	12	advmod	_	_
21	show	show	VBP	VBP	_	12	dep	_	_
22	a	a	DT	DT	_	25	det	_	_
23	markedly	markedly	RB	RB	_	24	advmod	_	_
24	reduced	reduce	VBN	VBN	_	25	amod	_	_
25	susceptibility	susceptibility	NN	NN	_	21	dobj	_	_
26	to	to	TO	TO	_	27	case	_	_
27	infection	infection	NN	NN	_	25	nmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	HIV-1	hiv-1	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	subclones	subclone	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	have	have	VB	VB	_	4	xcomp	_	_
7	an	a	DT	DT	_	9	det	_	_
8	abnormal	abnormal	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	6	dobj	_	_
10	to	to	TO	TO	_	19	case	_	_
11	the	the	DT	DT	_	19	det	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	C	c	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PKC	pkc	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	activator	activator	NN	NN	_	19	compound	_	_
19	PMA	pma	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	PMA	pma	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	CD3	cd3	NN	NN	_	10	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	CD25	cd25	NN	NN	_	4	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-2R	il-2r	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	receptors	receptor	NNS	NNS	_	3	dobj	_	_
11	on	on	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	parental	parental	JJ	JJ	_	14	amod	_	_
14	line	line	NN	NN	_	3	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	on	on	IN	IN	_	19	case	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	ethyl-methanesulfonate-derived	ethyl-methanesulfonate-derived	JJ	JJ	_	19	amod	_	_
19	subclones	subclone	NNS	NNS	_	14	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	but	but	CC	CC	_	14	cc	_	_
22	not	not	RB	RB	_	26	neg	_	_
23	on	on	IN	IN	_	26	case	_	_
24	these	these	DT	DT	_	26	det	_	_
25	two	two	CD	CD	_	26	nummod	_	_
26	mutants	mutant	NNS	NNS	_	14	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	assays	assay	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PKC	pkc	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	conducted	conduct	VBN	VBN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	Total	total	JJ	JJ	_	5	amod	_	_
2	cellular	cellular	JJ	JJ	_	5	amod	_	_
3	PKC	pkc	NN	NN	_	5	compound	_	_
4	enzymatic	enzymatic	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	normal	normal	JJ	JJ	_	7	xcomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	subclones	subclone	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	PMA-induced	pma-induced	JJ	JJ	_	3	amod	_	_
2	CD4	cd4	NN	NN	_	3	compound	_	_
3	down-modulation	down-modulation	NN	NN	_	4	nsubj	_	_
4	occurred	occur	VBD	VBD	_	0	root	_	_
5	normally	normally	RB	RB	_	4	advmod	_	_
6	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	activation	activation	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	c-raf	c-raf	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	normal	normal	JJ	JJ	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
3	long	long	JJ	JJ	_	5	amod	_	_
4	terminal	terminal	JJ	JJ	_	5	amod	_	_
5	repeat	repeat	NN	NN	_	6	nsubj	_	_
6	contains	contain	VBZ	VBZ	_	19	advcl	_	_
7	two	two	CD	CD	_	16	nummod	_	_
8	functional	functional	JJ	JJ	_	16	amod	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	kB	kb	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NF-kB	nf-kb	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	elements	element	NNS	NNS	_	6	dobj	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	studied	study	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	ability	ability	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	PMA	pma	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	induce	induce	VB	VB	_	21	acl	_	_
26	NF-kB	nf-kb	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	25	dobj	_	_
29	by	by	IN	IN	_	31	case	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	assays	assay	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	19	punct	_	_

1	Chloramphenicol	chloramphenicol	NN	NN	_	3	compound	_	_
2	acetyl	acetyl	NN	NN	_	3	compound	_	_
3	transferase	transferase	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	CAT	cat	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	assays	assay	NNS	NNS	_	18	nsubj	_	_
8	using	use	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	17	det	_	_
10	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	-139	-139	CD	CD	_	16	compound	_	_
13	)	)	-RRB-	-RRB-	_	16	punct	_	_
14	long	long	JJ	JJ	_	16	amod	_	_
15	terminal	terminal	JJ	JJ	_	16	amod	_	_
16	repeat-CAT	repeat-cat	JJ	JJ	_	17	amod	_	_
17	construct	construct	NN	NN	_	8	dobj	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	no	no	DT	DT	_	21	neg	_	_
20	PMA	pma	NN	NN	_	21	compound	_	_
21	induction	induction	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	CAT	cat	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	subclones	subclone	NNS	NNS	_	18	nmod	_	_
28	(	(	-LRB-	-LRB-	_	18	punct	_	_
29	unlike	unlike	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	parental	parental	JJ	JJ	_	32	amod	_	_
32	line	line	NN	NN	_	18	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	other	other	JJ	JJ	_	35	amod	_	_
35	subclones	subclone	NNS	NNS	_	32	conj	_	_
36	)	)	-RRB-	-RRB-	_	18	punct	_	_
37	.	.	.	.	_	18	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	14	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	an	a	DT	DT	_	5	det	_	_
5	inhibitor	inhibitor	NN	NN	_	2	appos	_	_
6	of	of	IN	IN	_	7	case	_	_
7	phosphatases	phosphatase	NNS	NNS	_	5	nmod	_	_
8	1	1	CD	CD	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	2A	2a	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	overcome	overcome	VB	VB	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	defect	defect	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	subclones	subclone	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	retardation	retardation	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	20	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	using	use	VBG	VBG	_	3	acl	_	_
6	a	a	DT	DT	_	7	det	_	_
7	32P-probe	32p-probe	NN	NN	_	5	dobj	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
11	NF-kB	nf-kb	NN	NN	_	12	compound	_	_
12	probe	probe	NN	NN	_	8	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	12	conj	_	_
16	from	from	IN	IN	_	18	case	_	_
17	PMA-treated	pma-treated	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	showed	show	VBD	VBD	_	0	root	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	reduced	reduce	VBN	VBN	_	23	amod	_	_
23	induction	induction	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
26	NF-kB	nf-kb	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	23	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	these	these	DT	DT	_	32	det	_	_
31	two	two	CD	CD	_	32	nummod	_	_
32	subclones	subclone	NNS	NNS	_	20	nmod	_	_
33	compared	compare	VBN	VBN	_	37	case	_	_
34	with	with	IN	IN	_	37	case	_	_
35	wild	wild	JJ	JJ	_	37	amod	_	_
36	type	type	NN	NN	_	37	compound	_	_
37	CEM	cem	NN	NN	_	20	advcl	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	a	a	DT	DT	_	41	det	_	_
40	control	control	NN	NN	_	41	compound	_	_
41	subclone	subclone	NN	NN	_	37	conj	_	_
42	.	.	.	.	_	20	punct	_	_

1	Deoxycholate	deoxycholate	JJ	JJ	_	2	amod	_	_
2	treatment	treatment	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cytoplasmic	cytoplasmic	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	2	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	subclones	subclone	NNS	NNS	_	5	nmod	_	_
9	released	release	VBD	VBD	_	0	root	_	_
10	much	much	JJ	JJ	_	11	dep	_	_
11	reduced	reduce	VBN	VBN	_	14	amod	_	_
12	NF-kB	nf-kb	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	9	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
17	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
18	pools	pool	NNS	NNS	_	9	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	reduced	reduced	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	17	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	PKC-induced	pkc-induced	JJ	JJ	_	9	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	NF-kB	nf-kb	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	two	two	CD	CD	_	14	nummod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	subclones	subclone	NNS	NNS	_	4	nmod	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	affect	affect	VB	VB	_	0	root	_	_
18	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
19	normal	normal	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	growth	growth	NN	NN	_	17	dobj	_	_
22	,	,	,	,	_	17	punct	_	_
23	but	but	CC	CC	_	17	cc	_	_
24	correlated	correlate	VBD	VBD	_	17	conj	_	_
25	with	with	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	pronounced	pronounced	JJ	JJ	_	28	amod	_	_
28	reduction	reduction	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	their	they	PRP$	PRP$	_	31	nmod:poss	_	_
31	susceptibility	susceptibility	NN	NN	_	28	nmod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	HIV-1	hiv-1	NN	NN	_	34	compound	_	_
34	infection	infection	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	17	punct	_	_

1	Eicosanoids	eicosanoid	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	breast	breast	NN	NN	_	5	compound	_	_
4	cancer	cancer	NN	NN	_	5	compound	_	_
5	patients	patient	NNS	NNS	_	1	nmod	_	_
6	before	before	IN	IN	_	9	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	after	after	IN	IN	_	6	conj	_	_
9	mastectomy	mastectomy	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	19	19	CD	CD	_	3	nummod	_	_
3	patients	patient	NNS	NNS	_	15	nmod	_	_
4	with	with	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	malignant	malignant	JJ	JJ	_	8	amod	_	_
7	breast	breast	NN	NN	_	8	compound	_	_
8	tumor	tumor	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	tumor	tumor	NN	NN	_	11	compound	_	_
11	tissue	tissue	NN	NN	_	15	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	blood	blood	NN	NN	_	11	conj	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	taken	take	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	determine	determine	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	20	det	_	_
19	eicosanoid	eicosanoid	NN	NN	_	20	compound	_	_
20	profile	profile	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	platelet	platelet	NN	NN	_	23	compound	_	_
23	aggregation	aggregation	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	15	punct	_	_

1	Values	value	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	compared	compare	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	those	those	DT	DT	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	benign	benign	JJ	JJ	_	10	amod	_	_
10	tumors	tumor	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	n	n	NN	NN	_	13	nsubj	_	_
13	=	=	JJ	JJ	_	10	dep	_	_
14	4	4	CD	CD	_	13	dobj	_	_
15	)	)	-RRB-	-RRB-	_	13	punct	_	_
16	,	,	,	,	_	10	punct	_	_
17	or	or	CC	CC	_	10	cc	_	_
18	undergoing	undergo	VBG	VBG	_	10	conj	_	_
19	a	a	DT	DT	_	21	det	_	_
20	mammary	mammary	JJ	JJ	_	21	amod	_	_
21	reduction	reduction	NN	NN	_	18	dobj	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	n	n	NN	NN	_	24	nsubj	_	_
24	=	=	JJ	JJ	_	21	dep	_	_
25	7	7	CD	CD	_	24	dobj	_	_
26	)	)	-RRB-	-RRB-	_	24	punct	_	_
27	.	.	.	.	_	3	punct	_	_

1	Postoperatively	postoperatively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	blood	blood	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	taken	take	VBN	VBN	_	0	root	_	_
6	as	as	RB	RB	_	7	advmod	_	_
7	well	well	RB	RB	_	5	advcl	_	_
8	in	in	IN	IN	_	11	mark	_	_
9	order	order	NN	NN	_	8	mwe	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	compare	compare	VB	VB	_	5	advcl	_	_
12	pre-	pre-	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	postoperative	postoperative	JJ	JJ	_	12	conj	_	_
15	values	value	NNS	NNS	_	11	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	Eicosanoids	eicosanoid	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	measured	measure	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	mammary	mammary	JJ	JJ	_	10	amod	_	_
10	tissue	tissue	NN	NN	_	7	conj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	means	means	NNS	NNS	_	14	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HPLC	hplc	NN	NN	_	3	nmod	_	_
15	;	;	:	:	_	3	punct	_	_
16	furthermore	furthermore	RBR	RBR	_	26	advmod	_	_
17	,	,	,	,	_	26	punct	_	_
18	TXA2	txa2	NN	NN	_	26	nsubjpass	_	_
19	,	,	,	,	_	18	punct	_	_
20	6-keto-PGF1	6-keto-pgf1	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	PGE2	pge2	NN	NN	_	18	conj	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	determined	determine	VBN	VBN	_	3	parataxis	_	_
27	by	by	IN	IN	_	28	case	_	_
28	RIA	ria	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	26	punct	_	_

1	Differences	difference	NNS	NNS	_	11	nsubjpass	_	_
2	in	in	IN	IN	_	6	case	_	_
3	pre-	pre-	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	postoperative	postoperative	JJ	JJ	_	3	conj	_	_
6	values	value	NNS	NNS	_	1	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cancer	cancer	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	plasma	plasma	NN	NN	_	15	compound	_	_
14	RIA	ria	NN	NN	_	15	compound	_	_
15	values	value	NNS	NNS	_	11	nmod	_	_
16	:	:	:	:	_	11	punct	_	_
17	PGE2	pge2	NN	NN	_	23	nsubj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	6-k-PGF1	6-k-pgf1	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	conj	_	_
21	were	be	VBD	VBD	_	23	cop	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	higher	higher	JJR	JJR	_	11	parataxis	_	_
24	preoperatively	preoperatively	RB	RB	_	23	advmod	_	_
25	when	when	WRB	WRB	_	26	advmod	_	_
26	compared	compare	VBN	VBN	_	23	advcl	_	_
27	with	with	IN	IN	_	28	case	_	_
28	postoperatively	postoperatively	RB	RB	_	26	advcl	_	_
29	,	,	,	,	_	23	punct	_	_
30	however	however	RB	RB	_	23	advmod	_	_
31	,	,	,	,	_	23	punct	_	_
32	such	such	JJ	JJ	_	33	amod	_	_
33	differences	difference	NNS	NNS	_	35	nsubjpass	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	seen	see	VBN	VBN	_	23	parataxis	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	control	control	NN	NN	_	39	compound	_	_
39	groups	group	NNS	NNS	_	35	nmod	_	_
40	as	as	RB	RB	_	41	advmod	_	_
41	well	well	RB	RB	_	35	advcl	_	_
42	.	.	.	.	_	11	punct	_	_

1	Compared	compare	VBN	VBN	_	9	case	_	_
2	to	to	TO	TO	_	9	case	_	_
3	benign	benign	JJ	JJ	_	4	amod	_	_
4	tumor	tumor	NN	NN	_	9	compound	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	mammary	mammary	JJ	JJ	_	7	amod	_	_
7	reduction	reduction	NN	NN	_	4	conj	_	_
8	test	test	NN	NN	_	9	compound	_	_
9	material	material	NN	NN	_	20	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	eicosanoid	eicosanoid	NN	NN	_	12	compound	_	_
12	profile	profile	NN	NN	_	20	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	tissue	tissue	NN	NN	_	12	nmod	_	_
15	obtained	obtain	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	19	case	_	_
17	malignant	malignant	JJ	JJ	_	19	amod	_	_
18	mammary	mammary	JJ	JJ	_	19	amod	_	_
19	tumors	tumor	NNS	NNS	_	15	nmod	_	_
20	showed	show	VBD	VBD	_	0	root	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	differences	difference	NNS	NNS	_	20	dobj	_	_
23	.	.	.	.	_	20	punct	_	_

1	Except	except	IN	IN	_	4	case	_	_
2	for	for	IN	IN	_	4	case	_	_
3	PGF2	pgf2	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	15	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	HHT	hht	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	15-HETE	15-hete	NN	NN	_	4	conj	_	_
9	no	no	DT	DT	_	11	neg	_	_
10	detectable	detectable	JJ	JJ	_	11	amod	_	_
11	quantities	quantity	NNS	NNS	_	15	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	eicosanoids	eicosanoid	NNS	NNS	_	11	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	non-tumor	non-tumor	JJ	JJ	_	19	amod	_	_
19	material	material	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	whereas	whereas	IN	IN	_	15	dep	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	malignant	malignant	JJ	JJ	_	26	amod	_	_
25	tumor	tumor	NN	NN	_	26	compound	_	_
26	material	material	NN	NN	_	36	nmod	_	_
27	substantial	substantial	JJ	JJ	_	28	amod	_	_
28	quantities	quantity	NNS	NNS	_	36	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	a	a	DT	DT	_	31	det	_	_
31	number	number	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	eicosanoid	eicosanoid	NN	NN	_	34	compound	_	_
34	metabolites	metabolite	NNS	NNS	_	31	nmod	_	_
35	were	be	VBD	VBD	_	36	cop	_	_
36	present	present	JJ	JJ	_	15	parataxis	_	_
37	.	.	.	.	_	15	punct	_	_

1	Statistically	statistically	RB	RB	_	2	advmod	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	correlations	correlation	NNS	NNS	_	6	nsubjpass	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	established	establish	VBN	VBN	_	0	root	_	_
7	between	between	IN	IN	_	9	case	_	_
8	patient/histopathology	patient/histopathology	NN	NN	_	9	compound	_	_
9	data	datum	NNS	NNS	_	6	advcl	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	results	result	NNS	NNS	_	9	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	platelet	platelet	NN	NN	_	17	compound	_	_
16	aggregation	aggregation	NN	NN	_	17	compound	_	_
17	assays	assay	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	e.g.	e.g.	FW	FW	_	9	dep	_	_
20	between	between	IN	IN	_	22	case	_	_
21	menopausal	menopausal	JJ	JJ	_	22	amod	_	_
22	status	status	NN	NN	_	9	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	ADP	adp	NN	NN	_	25	compound	_	_
25	aggregation	aggregation	NN	NN	_	22	conj	_	_
26	;	;	:	:	_	22	punct	_	_
27	oestrogen	oestrogen	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	22	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	+/-	+/-	JJ	JJ	_	28	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	collagen	collagen	NN	NN	_	28	conj	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	arachidonic	arachidonic	JJ	JJ	_	37	amod	_	_
36	acid	acid	NN	NN	_	37	compound	_	_
37	aggregation	aggregation	NN	NN	_	28	conj	_	_
38	,	,	,	,	_	22	punct	_	_
39	inflammatory	inflammatory	JJ	JJ	_	42	amod	_	_
40	cell	cell	NN	NN	_	42	compound	_	_
41	infiltration	infiltration	NN	NN	_	42	compound	_	_
42	score	score	NN	NN	_	22	conj	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	arachidonic	arachidonic	JJ	JJ	_	46	amod	_	_
45	acid	acid	NN	NN	_	46	compound	_	_
46	aggregation	aggregation	NN	NN	_	42	conj	_	_
47	and	and	CC	CC	_	22	cc	_	_
48	fibrosis	fibrosis	NN	NN	_	49	compound	_	_
49	score	score	NN	NN	_	22	conj	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	ADP	adp	NN	NN	_	52	compound	_	_
52	aggregation	aggregation	NN	NN	_	49	conj	_	_
53	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	eicosanoid	eicosanoid	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	14	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	material	material	NN	NN	_	6	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	mammary	mammary	JJ	JJ	_	12	amod	_	_
11	cancer	cancer	NN	NN	_	12	compound	_	_
12	patients	patient	NNS	NNS	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	different	different	JJ	JJ	_	3	ccomp	_	_
15	from	from	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	14	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	benign	benign	JJ	JJ	_	20	amod	_	_
19	mammary	mammary	JJ	JJ	_	20	amod	_	_
20	tissue	tissue	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	implications	implication	NNS	NNS	_	16	nsubj	_	_
3	,	,	,	,	_	11	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	particular	particular	JJ	JJ	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	in	in	IN	IN	_	11	case	_	_
8	relation	relation	NN	NN	_	11	dep	_	_
9	to	to	TO	TO	_	11	case	_	_
10	future	future	JJ	JJ	_	11	amod	_	_
11	prognosis	prognosis	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	patient	patient	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	remain	remain	VBP	VBP	_	0	root	_	_
17	obscure	obscure	JJ	JJ	_	16	xcomp	_	_
18	.	.	.	.	_	16	punct	_	_

1	c-myc	c-myc	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	minor	minor	JJ	JJ	_	7	amod	_	_
6	salivary	salivary	JJ	JJ	_	7	amod	_	_
7	glands	gland	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	Sjogren	sjogren	NN	NN	_	13	nmod:poss	_	_
12	's	's	POS	POS	_	11	case	_	_
13	syndrome	syndrome	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	c-myc	c-myc	NN	NN	_	2	compound	_	_
2	protooncogene	protooncogene	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	pathogenesis	pathogenesis	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	B	b	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	malignancies	malignancy	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	21	nsubjpass	_	_
16	of	of	IN	IN	_	19	case	_	_
17	c-myc	c-myc	NN	NN	_	19	compound	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	nmod	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	observed	observe	VBN	VBN	_	4	conj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	activated	activate	VBN	VBN	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Sjogren	sjogren	NN	NN	_	3	nmod:poss	_	_
2	's	's	POS	POS	_	1	case	_	_
3	syndrome	syndrome	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	SS	ss	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	characterized	characterize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	lymphocytic	lymphocytic	JJ	JJ	_	11	amod	_	_
11	infiltrates	infiltrate	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	exocrine	exocrine	JJ	JJ	_	14	amod	_	_
14	glands	gland	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	remarkable	remarkable	JJ	JJ	_	19	amod	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	hyperreactivity	hyperreactivity	NN	NN	_	11	conj	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	strong	strong	JJ	JJ	_	23	amod	_	_
23	predisposition	predisposition	NN	NN	_	11	conj	_	_
24	to	to	TO	TO	_	27	case	_	_
25	B	b	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	neoplasia	neoplasia	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	25	nmod	_	_
4	,	,	,	,	_	25	punct	_	_
5	c-myc	c-myc	NN	NN	_	8	compound	_	_
6	protooncogene	protooncogene	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	25	nsubjpass	_	_
9	in	in	IN	IN	_	15	case	_	_
10	29	29	CD	CD	_	15	nummod	_	_
11	labial	labial	JJ	JJ	_	15	amod	_	_
12	minor	minor	JJ	JJ	_	15	amod	_	_
13	salivary	salivary	JJ	JJ	_	15	amod	_	_
14	gland	gland	NN	NN	_	15	compound	_	_
15	biopsies	biopsy	NNS	NNS	_	8	nmod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	primary	primary	JJ	JJ	_	20	amod	_	_
20	SS	ss	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	15	15	CD	CD	_	23	nummod	_	_
23	controls	control	NNS	NNS	_	17	conj	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	examined	examine	VBN	VBN	_	0	root	_	_
26	using	use	VBG	VBG	_	25	xcomp	_	_
27	in	in	FW	FW	_	30	amod	_	_
28	situ	situ	FW	FW	_	27	dep	_	_
29	hybridization	hybridization	NN	NN	_	30	compound	_	_
30	histochemistry	histochemistry	NN	NN	_	26	dobj	_	_
31	.	.	.	.	_	25	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	40mer	40mer	JJ	JJ	_	3	amod	_	_
3	oligonucleotides	oligonucleotide	NNS	NNS	_	21	nsubjpass	_	_
4	from	from	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	1st	1st	JJ	JJ	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	9	det	_	_
9	2nd	2nd	JJ	JJ	_	6	conj	_	_
10	exon	exon	NN	NN	_	6	dep	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	c-myc	c-myc	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	6	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	labeled	label	VBN	VBN	_	3	acl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	35S	35s	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	used	use	VBN	VBN	_	0	root	_	_
22	as	as	IN	IN	_	23	case	_	_
23	probes	probe	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	21	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	detect	detect	VB	VB	_	23	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	origin	origin	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cell	cell	NN	NN	_	4	nmod	_	_
8	hybridized	hybridize	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	c-myc	c-myc	NN	NN	_	12	compound	_	_
12	probe	probe	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	23	punct	_	_
14	a	a	DT	DT	_	21	det	_	_
15	combined	combined	JJ	JJ	_	21	amod	_	_
16	immunochemistry	immunochemistry	NN	NN	_	21	compound	_	_
17	in	in	FW	FW	_	21	amod	_	_
18	situ	situ	FW	FW	_	17	dep	_	_
19	hybridization	hybridization	NN	NN	_	21	compound	_	_
20	histochemistry	histochemistry	NN	NN	_	21	compound	_	_
21	technique	technique	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	used	use	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	High	high	JJ	JJ	_	4	amod	_	_
2	c-myc	c-myc	NN	NN	_	4	compound	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	on	on	IN	IN	_	10	case	_	_
8	acinar	acinar	JJ	JJ	_	10	amod	_	_
9	epithelial	epithelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	c-myc	c-myc	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	correlate	correlate	VB	VB	_	0	root	_	_
5	with	with	IN	IN	_	10	case	_	_
6	c-fos	c-fos	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-jun	c-jun	NN	NN	_	6	conj	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Stronger	stronger	JJR	JJR	_	4	amod	_	_
2	c-myc	c-myc	NN	NN	_	4	compound	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	labial	labial	JJ	JJ	_	10	amod	_	_
9	salivary	salivary	JJ	JJ	_	10	amod	_	_
10	glands	gland	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	longer	longer	JJR	JJR	_	16	amod	_	_
15	disease	disease	NN	NN	_	16	compound	_	_
16	duration	duration	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	24	punct	_	_
18	p	p	NN	NN	_	24	dep	_	_
19	less	less	JJR	JJR	_	24	advmod	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	or	or	CC	CC	_	24	cc	_	_
22	equal	equal	JJ	JJ	_	24	advmod	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	0.002	0.002	CD	CD	_	16	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	16	cc	_	_
27	more	more	RBR	RBR	_	28	advmod	_	_
28	intense	intense	JJ	JJ	_	31	amod	_	_
29	T	t	NN	NN	_	31	compound	_	_
30	lymphocyte	lymphocyte	NN	NN	_	31	compound	_	_
31	infiltrates	infiltrate	NNS	NNS	_	16	conj	_	_
32	(	(	-LRB-	-LRB-	_	36	punct	_	_
33	p	p	NN	NN	_	36	dep	_	_
34	less	less	JJR	JJR	_	36	advmod	_	_
35	than	than	IN	IN	_	34	mwe	_	_
36	0.05	0.05	CD	CD	_	31	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	although	although	IN	IN	_	41	mark	_	_
39	these	these	DT	DT	_	40	det	_	_
40	patients	patient	NNS	NNS	_	41	nsubj	_	_
41	revealed	reveal	VBD	VBD	_	6	advcl	_	_
42	no	no	DT	DT	_	43	neg	_	_
43	hypergammaglobulinemia	hypergammaglobulinemia	NN	NN	_	41	dobj	_	_
44	.	.	.	.	_	6	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlation	correlation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	7	case	_	_
6	c-myc	c-myc	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	lymphocyte	lymphocyte	NN	NN	_	7	conj	_	_
11	monoclonicity	monoclonicity	NN	NN	_	10	dep	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	lymphoma	lymphoma	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	strong	strong	JJ	JJ	_	7	amod	_	_
5	c-myc	c-myc	NN	NN	_	7	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	on	on	IN	IN	_	12	case	_	_
11	epithelial	epithelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	labial	labial	JJ	JJ	_	16	amod	_	_
15	salivary	salivary	JJ	JJ	_	16	amod	_	_
16	glands	gland	NNS	NNS	_	12	nmod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	patients	patient	NNS	NNS	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	primary	primary	JJ	JJ	_	21	amod	_	_
21	SS	ss	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	indicate	indicate	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	reactivated	reactivate	VBN	VBN	_	10	amod	_	_
10	virus	virus	NN	NN	_	6	nmod	_	_
11	hosted	host	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Cytoplasmic	cytoplasmic	JJ	JJ	_	3	amod	_	_
2	domain	domain	NN	NN	_	3	compound	_	_
3	heterogeneity	heterogeneity	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	functions	function	NNS	NNS	_	3	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	IgG	igg	NN	NN	_	9	compound	_	_
8	Fc	fc	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	3	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	macrophages	macrophage	NNS	NNS	_	2	conj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	closely	closely	RB	RB	_	7	advmod	_	_
7	related	related	JJ	JJ	_	9	amod	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
9	G	g	NN	NN	_	5	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IgG	igg	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	Fc	fc	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	dep	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	Fc	fc	NN	NN	_	14	dep	_	_
17	gamma	gamma	NN	NN	_	16	dep	_	_
18	RII	rii	NN	NN	_	16	dep	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	differ	differ	VBP	VBP	_	9	acl:relcl	_	_
22	only	only	RB	RB	_	21	advmod	_	_
23	in	in	IN	IN	_	22	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	structures	structure	NNS	NNS	_	22	nmod:npmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
28	cytoplasmic	cytoplasmic	JJ	JJ	_	29	amod	_	_
29	domains	domain	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Because	because	IN	IN	_	8	case	_	_
2	of	of	IN	IN	_	1	mwe	_	_
3	cell	cell	NN	NN	_	4	nmod:npmod	_	_
4	type-specific	type-specific	JJ	JJ	_	8	amod	_	_
5	alternative	alternative	JJ	JJ	_	8	amod	_	_
6	messenger	messenger	NN	NN	_	8	compound	_	_
7	RNA	rna	NN	NN	_	8	compound	_	_
8	splicing	splicing	NN	NN	_	14	nmod	_	_
9	,	,	,	,	_	14	punct	_	_
10	B-cell	b-cell	NN	NN	_	13	compound	_	_
11	Fc	fc	NN	NN	_	13	compound	_	_
12	gamma	gamma	NN	NN	_	13	compound	_	_
13	RII	rii	NN	NN	_	14	nsubj	_	_
14	contains	contain	VBZ	VBZ	_	0	root	_	_
15	an	a	DT	DT	_	16	det	_	_
16	insertion	insertion	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	47	47	CD	CD	_	20	nummod	_	_
19	amino	amino	NN	NN	_	20	compound	_	_
20	acids	acid	NNS	NNS	_	16	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	participates	participate	VBZ	VBZ	_	16	acl:relcl	_	_
23	in	in	IN	IN	_	24	mark	_	_
24	determining	determine	VBG	VBG	_	22	advcl	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	function	function	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	14	punct	_	_

1	Transfection	transfection	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	an	a	DT	DT	_	8	det	_	_
4	Fc	fc	NN	NN	_	6	nmod:npmod	_	_
5	gamma	gamma	NN	NN	_	6	nmod:npmod	_	_
6	RII-negative	rii-negative	JJ	JJ	_	8	amod	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	1	nmod	_	_
9	with	with	IN	IN	_	13	mark	_	_
10	complementary	complementary	JJ	JJ	_	11	amod	_	_
11	DNA	dna	NN	NN	_	13	nsubj	_	_
12	's	's	POS	POS	_	11	case	_	_
13	encoding	encode	VBG	VBG	_	1	acl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	splice	splice	NN	NN	_	17	compound	_	_
17	products	product	NNS	NNS	_	13	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	various	various	JJ	JJ	_	21	amod	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	mutants	mutant	NNS	NNS	_	17	conj	_	_
22	indicated	indicate	VBD	VBD	_	0	root	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	insertion	insertion	NN	NN	_	27	nsubj	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	responsible	responsible	JJ	JJ	_	22	ccomp	_	_
28	for	for	IN	IN	_	29	mark	_	_
29	preventing	prevent	VBG	VBG	_	27	advcl	_	_
30	both	both	CC	CC	_	34	cc:preconj	_	_
31	Fc	fc	NN	NN	_	33	nmod:npmod	_	_
32	gamma	gamma	NN	NN	_	33	nmod:npmod	_	_
33	RII-mediated	rii-mediated	JJ	JJ	_	34	amod	_	_
34	endocytosis	endocytosis	NN	NN	_	29	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	Fc	fc	NN	NN	_	38	nmod:npmod	_	_
37	gamma	gamma	NN	NN	_	38	nmod:npmod	_	_
38	RII-mediated	rii-mediated	JJ	JJ	_	40	amod	_	_
39	antigen	antigen	NN	NN	_	40	compound	_	_
40	presentation	presentation	NN	NN	_	34	conj	_	_
41	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	insertion	insertion	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	11	mark	_	_
7	Fc	fc	NN	NN	_	9	compound	_	_
8	gamma	gamma	NN	NN	_	9	compound	_	_
9	RII	rii	NN	NN	_	11	nsubj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	modulate	modulate	VB	VB	_	5	advcl	_	_
12	surface	surface	NN	NN	_	15	compound	_	_
13	immunoglobulin-triggered	immunoglobulin-triggered	JJ	JJ	_	15	amod	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	Instead	instead	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	regulation	regulation	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	activation	activation	NN	NN	_	3	nmod	_	_
6	involved	involve	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	region	region	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	8	nmod	_	_
13	common	common	JJ	JJ	_	8	amod	_	_
14	to	to	TO	TO	_	21	case	_	_
15	both	both	CC	CC	_	21	cc:preconj	_	_
16	the	the	DT	DT	_	21	det	_	_
17	lymphocyte	lymphocyte	NN	NN	_	21	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	macrophage	macrophage	NN	NN	_	17	conj	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	isoforms	isoform	NNS	NNS	_	13	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	insertion	insertion	NN	NN	_	7	nsubj	_	_
6	did	do	VBD	VBD	_	7	aux	_	_
7	contribute	contribute	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	formation	formation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	caps	cap	NNS	NNS	_	10	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	response	response	NN	NN	_	17	dep	_	_
15	to	to	TO	TO	_	17	case	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	cross-linking	cross-linking	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	consistent	consistent	JJ	JJ	_	7	xcomp	_	_
20	with	with	IN	IN	_	21	case	_	_
21	suggestions	suggestion	NNS	NNS	_	19	nmod	_	_
22	that	that	IN	IN	_	33	mark	_	_
23	the	the	DT	DT	_	28	det	_	_
24	lymphocyte	lymphocyte	NN	NN	_	28	compound	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	24	cc	_	_
27	macrophage	macrophage	NN	NN	_	24	conj	_	_
28	form	form	NN	NN	_	33	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	receptor	receptor	NN	NN	_	28	nmod	_	_
32	can	can	MD	MD	_	33	aux	_	_
33	associate	associate	VB	VB	_	21	ccomp	_	_
34	with	with	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	detergent-insoluble	detergent-insoluble	JJ	JJ	_	37	amod	_	_
37	cytoskeleton	cytoskeleton	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	Every	every	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	3	nsubj	_	_
3	works	work	VBZ	VBZ	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	every	every	DT	DT	_	6	det	_	_
6	promoter	promoter	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	all	all	PDT	PDT	_	10	det:predet	_	_
9	the	the	DT	DT	_	10	det	_	_
10	combinations	combination	NNS	NNS	_	3	nmod	_	_
11	tested	test	VBN	VBN	_	10	acl	_	_
12	:	:	:	:	_	3	punct	_	_
13	could	could	MD	MD	_	17	aux	_	_
14	new	new	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	pathways	pathway	NNS	NNS	_	17	nsubj	_	_
17	evolve	evolve	VBP	VBP	_	3	parataxis	_	_
18	by	by	IN	IN	_	20	case	_	_
19	enhancer	enhancer	NN	NN	_	20	compound	_	_
20	shuffling	shuffling	NN	NN	_	17	nmod	_	_
21	?	?	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoters	promoter	NNS	NNS	_	11	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	enhancers	enhancer	NNS	NNS	_	2	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	cell	cell	NN	NN	_	7	nmod:npmod	_	_
7	type-specific	type-specific	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	often	often	RB	RB	_	11	advmod	_	_
11	conserved	conserve	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	evolution	evolution	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	hence	hence	RB	RB	_	11	advmod	_	_
17	one	one	NN	NN	_	19	nsubj	_	_
18	might	might	MD	MD	_	19	aux	_	_
19	expect	expect	VB	VB	_	11	ccomp	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	a	a	DT	DT	_	23	det	_	_
22	given	given	JJ	JJ	_	23	amod	_	_
23	enhancer	enhancer	NN	NN	_	25	nsubj	_	_
24	has	have	VBZ	VBZ	_	25	aux	_	_
25	evolved	evolve	VBN	VBN	_	19	ccomp	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	work	work	VB	VB	_	25	xcomp	_	_
28	best	best	RBS	RBS	_	27	advmod	_	_
29	with	with	IN	IN	_	32	case	_	_
30	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
31	own	own	JJ	JJ	_	32	amod	_	_
32	promoter	promoter	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	While	while	IN	IN	_	6	mark	_	_
2	this	this	DT	DT	_	3	det	_	_
3	expectation	expectation	NN	NN	_	6	nsubjpass	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	realized	realize	VBN	VBN	_	14	advcl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	some	some	DT	DT	_	9	det	_	_
9	cases	case	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	we	we	PRP	PRP	_	14	nsubj	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	evidence	evidence	NN	NN	_	14	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	it	it	PRP	PRP	_	15	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	total	total	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	27	27	CD	CD	_	5	nummod	_	_
5	combinations	combination	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	promoters	promoter	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	enhancers	enhancer	NNS	NNS	_	8	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	tested	test	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	transfection	transfection	NN	NN	_	12	nmod	_	_
15	into	into	IN	IN	_	17	case	_	_
16	cultured	culture	VBN	VBN	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	relative	relative	JJ	JJ	_	6	amod	_	_
6	efficiency	efficiency	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	enhancers	enhancer	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	15	cop	_	_
11	approximately	approximately	RB	RB	_	13	advmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	same	same	JJ	JJ	_	15	dep	_	_
14	,	,	,	,	_	15	punct	_	_
15	irrespective	irrespective	JJ	JJ	_	2	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	type	type	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	promoter	promoter	NN	NN	_	18	nmod	_	_
21	used	use	VBN	VBN	_	20	acl	_	_
22	,	,	,	,	_	15	punct	_	_
23	i.e.	i.e.	FW	FW	_	15	dep	_	_
24	,	,	,	,	_	15	punct	_	_
25	there	there	EX	EX	_	26	expl	_	_
26	was	be	VBD	VBD	_	15	parataxis	_	_
27	no	no	DT	DT	_	29	neg	_	_
28	strong	strong	JJ	JJ	_	29	amod	_	_
29	preference	preference	NN	NN	_	26	nsubj	_	_
30	for	for	IN	IN	_	34	case	_	_
31	any	any	DT	DT	_	34	det	_	_
32	given	given	JJ	JJ	_	34	amod	_	_
33	enhancer/promoter	enhancer/promoter	JJ	JJ	_	34	amod	_	_
34	combination	combination	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	Notably	notably	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	do	do	VBP	VBP	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	see	see	VB	VB	_	0	root	_	_
7	particularly	particularly	RB	RB	_	8	advmod	_	_
8	strong	strong	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	when	when	WRB	WRB	_	24	advmod	_	_
11	the	the	DT	DT	_	14	det	_	_
12	immunoglobulin	immunoglobulin	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	24	nsubjpass	_	_
15	(	(	-LRB-	-LRB-	_	14	punct	_	_
16	or	or	CC	CC	_	14	cc	_	_
17	the	the	DT	DT	_	21	det	_	_
18	immunoglobulin	immunoglobulin	NN	NN	_	21	compound	_	_
19	heavy	heavy	JJ	JJ	_	21	amod	_	_
20	chain	chain	NN	NN	_	21	compound	_	_
21	enhancer	enhancer	NN	NN	_	14	conj	_	_
22	)	)	-RRB-	-RRB-	_	14	punct	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	used	use	VBN	VBN	_	6	advcl	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	activate	activate	VB	VB	_	24	xcomp	_	_
27	a	a	DT	DT	_	30	det	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	26	dobj	_	_
31	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	a	a	DT	DT	_	8	det	_	_
5	generally	generally	RB	RB	_	6	advmod	_	_
6	permissive	permissive	JJ	JJ	_	8	amod	_	_
7	enhancer/promoter	enhancer/promoter	JJ	JJ	_	8	amod	_	_
8	interaction	interaction	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	of	of	IN	IN	_	12	case	_	_
11	evolutionary	evolutionary	JJ	JJ	_	12	amod	_	_
12	benefit	benefit	NN	NN	_	2	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	higher	higher	JJR	JJR	_	15	amod	_	_
15	eukaryotes	eukaryote	NNS	NNS	_	12	nmod	_	_
16	:	:	:	:	_	12	punct	_	_
17	by	by	IN	IN	_	19	case	_	_
18	enhancer	enhancer	NN	NN	_	19	compound	_	_
19	shuffling	shuffling	NN	NN	_	25	nmod	_	_
20	,	,	,	,	_	25	punct	_	_
21	genes	gene	NNS	NNS	_	25	nsubjpass	_	_
22	could	could	MD	MD	_	25	aux	_	_
23	be	be	VB	VB	_	25	auxpass	_	_
24	easily	easily	RB	RB	_	25	advmod	_	_
25	brought	bring	VBN	VBN	_	12	parataxis	_	_
26	under	under	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	new	new	JJ	JJ	_	29	amod	_	_
29	type	type	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	inducibility/cell	inducibility/cell	NN	NN	_	33	compound	_	_
32	type	type	NN	NN	_	33	compound	_	_
33	specificity	specificity	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Heterodimerization	heterodimerization	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	1	conj	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vitro	vitro	FW	FW	_	1	advmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	family	family	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	4	nmod	_	_
8	represents	represent	VBZ	VBZ	_	0	root	_	_
9	multiple	multiple	JJ	JJ	_	11	amod	_	_
10	DNA	dna	NN	NN	_	11	compound	_	_
11	binding	binding	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	rel	rel	NN	NN	_	14	nmod:npmod	_	_
14	related	related	JJ	JJ	_	15	amod	_	_
15	polypeptides	polypeptide	NNS	NNS	_	11	appos	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	contribute	contribute	VBP	VBP	_	15	acl:relcl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	regulation	regulation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	genes	gene	NNS	NNS	_	19	nmod	_	_
22	involved	involve	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	immune	immune	JJ	JJ	_	25	amod	_	_
25	responsiveness	responsiveness	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	inflammation	inflammation	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	19	punct	_	_
29	as	as	RB	RB	_	19	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	activation	activation	NN	NN	_	19	conj	_	_
33	of	of	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	HIV	hiv	NN	NN	_	38	compound	_	_
36	long	long	JJ	JJ	_	38	amod	_	_
37	terminal	terminal	JJ	JJ	_	38	amod	_	_
38	repeat	repeat	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	multiple	multiple	JJ	JJ	_	8	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	nmod:npmod	_	_
7	related	related	JJ	JJ	_	8	amod	_	_
8	polypeptides	polypeptide	NNS	NNS	_	16	nsubjpass	_	_
9	ranging	range	VBG	VBG	_	8	acl	_	_
10	from	from	IN	IN	_	13	advmod	_	_
11	85	85	CD	CD	_	13	compound	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	45	45	CD	CD	_	14	dep	_	_
14	kDa	kda	NN	NN	_	9	advcl	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	for	for	IN	IN	_	19	case	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	capacity	capacity	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	interact	interact	VB	VB	_	19	acl	_	_
22	with	with	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	PRDII	prdii	NN	NN	_	26	compound	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	element	element	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	interferon	interferon	NN	NN	_	29	compound	_	_
29	beta	beta	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	16	cc	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	shown	show	VBN	VBN	_	16	conj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	possess	possess	VB	VB	_	32	xcomp	_	_
35	distinct	distinct	JJ	JJ	_	39	amod	_	_
36	intrinsic	intrinsic	JJ	JJ	_	39	amod	_	_
37	DNA	dna	NN	NN	_	39	compound	_	_
38	binding	binding	NN	NN	_	39	compound	_	_
39	affinities	affinity	NNS	NNS	_	34	dobj	_	_
40	for	for	IN	IN	_	44	case	_	_
41	this	this	DT	DT	_	44	det	_	_
42	NF-kappa	nf-kappa	NN	NN	_	44	compound	_	_
43	B	b	NN	NN	_	44	compound	_	_
44	site	site	NN	NN	_	39	nmod	_	_
45	and	and	CC	CC	_	34	cc	_	_
46	form	form	VB	VB	_	34	conj	_	_
47	multiple	multiple	JJ	JJ	_	50	amod	_	_
48	DNA	dna	NN	NN	_	50	nmod:npmod	_	_
49	binding	binding	NN	NN	_	50	nmod:npmod	_	_
50	homo-	homo-	JJ	JJ	_	46	dobj	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	heterodimer	heterodimer	NN	NN	_	53	compound	_	_
53	complexes	complex	NNS	NNS	_	50	conj	_	_
54	in	in	IN	IN	_	56	case	_	_
55	co-renaturation	co-renaturation	NN	NN	_	56	compound	_	_
56	experiments	experiment	NNS	NNS	_	46	nmod	_	_
57	.	.	.	.	_	16	punct	_	_

1	Furthermore	furthermore	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	using	use	VBG	VBG	_	25	advcl	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	templates	template	NNS	NNS	_	3	dobj	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	copies	copy	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	PRDII	prdii	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	8	nmod	_	_
13	linked	link	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	rabbit	rabbit	NN	NN	_	19	compound	_	_
17	beta	beta	NN	NN	_	19	compound	_	_
18	globin	globin	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	25	punct	_	_
21	the	the	DT	DT	_	23	det	_	_
22	purified	purify	VBN	VBN	_	23	amod	_	_
23	polypeptides	polypeptide	NNS	NNS	_	25	nsubj	_	_
24	specifically	specifically	RB	RB	_	25	advmod	_	_
25	stimulated	stimulate	VBD	VBD	_	0	root	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	28	nmod:npmod	_	_
28	dependent	dependent	JJ	JJ	_	29	amod	_	_
29	transcription	transcription	NN	NN	_	25	dobj	_	_
30	in	in	IN	IN	_	35	case	_	_
31	an	a	DT	DT	_	35	det	_	_
32	in	in	FW	FW	_	35	amod	_	_
33	vitro	vitro	FW	FW	_	32	dep	_	_
34	reconstitution	reconstitution	NN	NN	_	35	compound	_	_
35	assay	assay	NN	NN	_	29	nmod	_	_
36	as	as	IN	IN	_	37	case	_	_
37	heterodimers	heterodimer	NNS	NNS	_	25	nmod	_	_
38	but	but	CC	CC	_	37	cc	_	_
39	not	not	RB	RB	_	42	neg	_	_
40	as	as	IN	IN	_	42	case	_	_
41	p50	p50	NN	NN	_	42	compound	_	_
42	homodimers	homodimer	NNS	NNS	_	37	conj	_	_
43	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	emphasize	emphasize	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	dimerization	dimerization	NN	NN	_	5	nmod	_	_
10	as	as	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	distinct	distinct	JJ	JJ	_	13	amod	_	_
13	level	level	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	control	control	NN	NN	_	13	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	permit	permit	VB	VB	_	16	acl:relcl	_	_
20	functional	functional	JJ	JJ	_	21	amod	_	_
21	diversification	diversification	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	limited	limited	JJ	JJ	_	25	amod	_	_
25	number	number	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	regulatory	regulatory	JJ	JJ	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Oct2	oct2	NN	NN	_	2	compound	_	_
2	transactivation	transactivation	NN	NN	_	8	nsubj	_	_
3	from	from	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	remote	remote	JJ	JJ	_	7	amod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	position	position	NN	NN	_	2	nmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	B-cell-restricted	b-cell-restricted	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	8	punct	_	_

1	Previous	previous	JJ	JJ	_	3	amod	_	_
2	cotransfection	cotransfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
4	had	have	VBD	VBD	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	ectopic	ectopic	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	17	nsubj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	14	amod	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	Oct2	oct2	NN	NN	_	8	nmod	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	efficiently	efficiently	RB	RB	_	17	advmod	_	_
17	activate	activate	VB	VB	_	5	ccomp	_	_
18	a	a	DT	DT	_	19	det	_	_
19	promoter	promoter	NN	NN	_	17	dobj	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	an	a	DT	DT	_	23	det	_	_
22	octamer	octamer	NN	NN	_	23	compound	_	_
23	motif	motif	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Oct2	oct2	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	unable	unable	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	stimulate	stimulate	VB	VB	_	4	xcomp	_	_
7	a	a	DT	DT	_	11	det	_	_
8	multimerized	multimerized	JJ	JJ	_	11	amod	_	_
9	octamer	octamer	NN	NN	_	11	compound	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	6	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	HeLa	hela	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	however	however	RB	RB	_	4	advmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	tested	test	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	variety	variety	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Oct2	oct2	NN	NN	_	5	nmod	_	_
8	isoforms	isoform	VBZ	VBZ	_	7	dep	_	_
9	generated	generate	VBN	VBN	_	7	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	alternative	alternative	JJ	JJ	_	12	amod	_	_
12	splicing	splicing	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	capability	capability	NN	NN	_	3	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	activate	activate	VB	VB	_	15	acl	_	_
18	an	a	DT	DT	_	20	det	_	_
19	octamer	octamer	NN	NN	_	20	compound	_	_
20	enhancer	enhancer	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	nonlymphoid	nonlymphoid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	a	a	DT	DT	_	27	det	_	_
26	B-cell	b-cell	NN	NN	_	27	compound	_	_
27	line	line	NN	NN	_	23	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	Oct2	oct2	NN	NN	_	7	compound	_	_
7	isoforms	isoform	NNS	NNS	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	stimulate	stimulate	VB	VB	_	3	ccomp	_	_
10	from	from	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	remote	remote	JJ	JJ	_	13	amod	_	_
13	position	position	NN	NN	_	9	nmod	_	_
14	but	but	CC	CC	_	9	cc	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	stimulation	stimulation	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	aux	_	_
19	restricted	restricted	JJ	JJ	_	9	conj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	either	either	CC	CC	_	10	cc:preconj	_	_
8	a	a	DT	DT	_	10	det	_	_
9	B-cell-specific	b-cell-specific	JJ	JJ	_	10	amod	_	_
10	cofactor	cofactor	NN	NN	_	5	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	a	a	DT	DT	_	14	det	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	modification	modification	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	cofactor	cofactor	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Oct2	oct2	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	Oct2-mediated	oct2-mediated	JJ	JJ	_	25	amod	_	_
24	enhancer	enhancer	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	5	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	carboxy-terminal	carboxy-terminal	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Oct2	oct2	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	critical	critical	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	enhancer	enhancer	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	domain	domain	NN	NN	_	5	nsubj	_	_
5	conferred	confer	VBD	VBD	_	0	root	_	_
6	enhancing	enhancing	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	when	when	WRB	WRB	_	9	advmod	_	_
9	fused	fuse	VBN	VBN	_	5	dep	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Oct1	oct1	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	19	nsubj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	itself	itself	PRP	PRP	_	19	nmod	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	unable	unable	JJ	JJ	_	13	acl:relcl	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	stimulate	stimulate	VB	VB	_	19	xcomp	_	_
22	from	from	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	remote	remote	JJ	JJ	_	25	amod	_	_
25	position	position	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	glutamine-rich	glutamine-rich	JJ	JJ	_	4	amod	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	domain	domain	NN	NN	_	16	nsubj	_	_
5	present	present	JJ	JJ	_	4	amod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	amino-terminal	amino-terminal	JJ	JJ	_	9	amod	_	_
9	portion	portion	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Oct2	oct2	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	POU	pou	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	4	conj	_	_
16	contribute	contribute	VBP	VBP	_	0	root	_	_
17	only	only	RB	RB	_	18	advmod	_	_
18	marginally	marginally	RB	RB	_	16	advmod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transactivation	transactivation	NN	NN	_	22	compound	_	_
22	function	function	NN	NN	_	16	nmod	_	_
23	from	from	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	distal	distal	JJ	JJ	_	26	amod	_	_
26	position	position	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	POU	pou	NN	NN	_	8	compound	_	_
5	domain	domain	NN	NN	_	8	compound	_	_
6	transcription	transcription	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	Oct-2	oct-2	NN	NN	_	1	nmod	_	_
9	during	during	IN	IN	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	1	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	cognate	cognate	JJ	JJ	_	14	amod	_	_
14	antigen	antigen	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Oct-2	oct-2	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
8	specifically	specifically	RB	RB	_	12	advmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	octamer	octamer	NN	NN	_	12	compound	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	motifs	motif	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	promoters	promoter	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	immunoglobulin	immunoglobulin	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	interleukin-2	interleukin-2	NN	NN	_	17	conj	_	_
20	genes	gene	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	4	det	_	_
2	tumor	tumor	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	16	nsubj	_	_
5	from	from	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	lineage	lineage	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	a	a	DT	DT	_	11	det	_	_
11	few	few	JJ	JJ	_	4	conj	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	lineage	lineage	NN	NN	_	11	nmod	_	_
16	express	express	VBP	VBP	_	0	root	_	_
17	Oct-2	oct-2	NN	NN	_	16	dobj	_	_
18	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Oct-2	oct-2	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	lineage	lineage	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	studied	study	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Oct-2	oct-2	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	protein	protein	NN	NN	_	18	conj	_	_
21	in	in	IN	IN	_	27	case	_	_
22	nontransformed	nontransformed	JJ	JJ	_	27	amod	_	_
23	human	human	JJ	JJ	_	27	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	mouse	mouse	NN	NN	_	23	conj	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	15	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	Oct-2	oct-2	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	9	case	_	_
5	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CD8+	cd8+	JJ	JJ	_	5	conj	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	prepared	prepare	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
14	blood	blood	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	in	in	IN	IN	_	21	case	_	_
17	mouse	mouse	NN	NN	_	21	compound	_	_
18	lymph	lymph	NN	NN	_	21	compound	_	_
19	node	node	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	9	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	clone	clone	NN	NN	_	18	nmod	_	_
5	specific	specific	JJ	JJ	_	4	amod	_	_
6	for	for	IN	IN	_	9	case	_	_
7	pigeon	pigeon	NN	NN	_	9	compound	_	_
8	cytochrome	cytochrome	NN	NN	_	9	compound	_	_
9	c	c	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	dep	_	_
12	context	context	NN	NN	_	14	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	I-Ek	i-ek	NN	NN	_	5	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	Oct-2	oct-2	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	induced	induce	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	21	case	_	_
20	antigen	antigen	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	with	with	IN	IN	_	29	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	increase	increase	NN	NN	_	29	nsubj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	Oct-2	oct-2	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	25	nmod	_	_
29	seen	see	VBN	VBN	_	18	advcl	_	_
30	first	first	RB	RB	_	29	advmod	_	_
31	at	at	IN	IN	_	33	case	_	_
32	3	3	CD	CD	_	33	nummod	_	_
33	h	h	NN	NN	_	29	nmod	_	_
34	after	after	IN	IN	_	35	case	_	_
35	activation	activation	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	continuing	continue	VBG	VBG	_	29	conj	_	_
38	for	for	IN	IN	_	42	case	_	_
39	at	at	IN	IN	_	40	case	_	_
40	least	least	JJS	JJS	_	41	nmod:npmod	_	_
41	24	24	CD	CD	_	42	nummod	_	_
42	h	h	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	18	punct	_	_

1	Oct-2	oct-2	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	9	nsubjpass	_	_
4	during	during	IN	IN	_	7	case	_	_
5	antigen-driven	antigen-driven	JJ	JJ	_	7	amod	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	as	as	RB	RB	_	12	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	by	by	IN	IN	_	20	case	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	synthesis	synthesis	NN	NN	_	20	compound	_	_
20	inhibitors	inhibitor	NNS	NNS	_	12	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Oct-2	oct-2	NN	NN	_	6	nsubj	_	_
6	participates	participate	VBZ	VBZ	_	3	ccomp	_	_
7	in	in	IN	IN	_	9	case	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	during	during	IN	IN	_	12	case	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	relatively	relatively	RB	RB	_	3	advmod	_	_
3	delayed	delay	VBN	VBN	_	4	amod	_	_
4	kinetics	kinetics	NNS	NNS	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Oct-2	oct-2	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	suggests	suggest	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	Oct-2	oct-2	NN	NN	_	11	nsubj	_	_
11	mediates	mediate	VBZ	VBZ	_	8	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	changes	change	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	occur	occur	VBP	VBP	_	13	acl:relcl	_	_
19	many	many	JJ	JJ	_	20	amod	_	_
20	hours	hour	NNS	NNS	_	18	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	days	day	NNS	NNS	_	20	conj	_	_
23	following	follow	VBG	VBG	_	20	dep	_	_
24	antigen	antigen	NN	NN	_	25	compound	_	_
25	stimulation	stimulation	NN	NN	_	20	dep	_	_
26	of	of	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Changes	change	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	plasma	plasma	NN	NN	_	5	compound	_	_
5	interleukin-1	interleukin-1	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
8	possible	possible	JJ	JJ	_	9	amod	_	_
9	relationship	relationship	NN	NN	_	2	conj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	changes	change	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	aged	aged	JJ	JJ	_	19	amod	_	_
18	long-distance	long-distance	JJ	JJ	_	19	amod	_	_
19	runner	runner	NN	NN	_	2	nmod	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	40	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	changes	change	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	plasma	plasma	NN	NN	_	6	nmod	_	_
9	interleukin-1	interleukin-1	NN	NN	_	8	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-1	il-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
15	possible	possible	JJ	JJ	_	16	amod	_	_
16	relationship	relationship	NN	NN	_	6	conj	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	changes	change	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	GR	gr	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	40	punct	_	_
27	plasma	plasma	NN	NN	_	28	compound	_	_
28	IL-1	il-1	NN	NN	_	40	nsubjpass	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	GR	gr	NN	NN	_	28	conj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	peripheral	peripheral	JJ	JJ	_	34	amod	_	_
33	blood	blood	NN	NN	_	34	compound	_	_
34	leukocytes	leukocyte	NNS	NNS	_	28	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	aged	aged	JJ	JJ	_	38	amod	_	_
37	long-distance	long-distance	JJ	JJ	_	38	amod	_	_
38	runner	runner	NN	NN	_	34	nmod	_	_
39	were	be	VBD	VBD	_	40	auxpass	_	_
40	measured	measure	VBN	VBN	_	0	root	_	_
41	simultaneously	simultaneously	RB	RB	_	40	advmod	_	_
42	.	.	.	.	_	40	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IL-1	il-1	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	ability	ability	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	stimulate	stimulate	VB	VB	_	9	acl	_	_
12	3H-TdR	3h-tdr	NN	NN	_	13	compound	_	_
13	incorporation	incorporation	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	thymocytes	thymocyte	NNS	NNS	_	11	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	C57	c57	NN	NN	_	19	compound	_	_
19	mice	mouse	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	GR	gr	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	whole	whole	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	3H-Dex	3h-dex	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	plasma	plasma	NN	NN	_	9	compound	_	_
9	IL-1	il-1	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	aged	aged	JJ	JJ	_	13	amod	_	_
12	long-distance	long-distance	JJ	JJ	_	13	amod	_	_
13	runner	runner	NN	NN	_	9	nmod	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	209	209	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	3	ccomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	223	223	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	16	conj	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	145	145	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	16	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	control	control	NN	NN	_	16	nmod	_	_
26	at	at	IN	IN	_	33	case	_	_
27	14.7-18.7	14.7-18.7	CD	CD	_	32	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	3.8-7.0	3.8-7.0	CD	CD	_	27	dep	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	1.5-2.6	1.5-2.6	CD	CD	_	27	conj	_	_
32	KD	kd	NN	NN	_	33	dep	_	_
33	fractions	fraction	NNS	NNS	_	16	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	GR	gr	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	aged	aged	JJ	JJ	_	9	amod	_	_
9	runner	runner	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	65	65	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	control	control	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	Possible	possible	JJ	JJ	_	2	amod	_	_
2	relationship	relationship	NN	NN	_	19	nsubjpass	_	_
3	between	between	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	changes	change	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	IL-1	il-1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	GR	gr	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	aged	aged	JJ	JJ	_	13	amod	_	_
12	long-distance	long-distance	JJ	JJ	_	13	amod	_	_
13	runner	runner	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	2	cc	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	physiological	physiological	JJ	JJ	_	17	amod	_	_
17	significance	significance	NN	NN	_	2	conj	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	discussed	discuss	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	AP-2	ap-2	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	HTLV-I	htlv-i	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HTLV-I	htlv-i	NN	NN	_	3	compound	_	_
3	LTR	ltr	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	three	three	CD	CD	_	8	nummod	_	_
6	conserved	conserve	VBN	VBN	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	elements	element	NNS	NNS	_	4	dobj	_	_
9	known	know	VBN	VBN	_	8	acl	_	_
10	as	as	IN	IN	_	14	case	_	_
11	21	21	CD	CD	_	13	compound	_	_
12	base	base	NN	NN	_	13	dep	_	_
13	pair	pair	NN	NN	_	14	amod	_	_
14	repeats	repeat	NNS	NNS	_	9	nmod	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	14	acl:relcl	_	_
18	for	for	IN	IN	_	19	case	_	_
19	stimulation	stimulation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	transactivator	transactivator	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	tax	tax	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Mutagenesis	mutagenesis	NN	NN	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	21	21	CD	CD	_	6	compound	_	_
6	bp	bp	NN	NN	_	7	amod	_	_
7	repeats	repeat	NNS	NNS	_	10	nsubjpass	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	subdivided	subdivide	VBN	VBN	_	2	ccomp	_	_
11	into	into	IN	IN	_	13	case	_	_
12	three	three	CD	CD	_	13	nummod	_	_
13	motifs	motif	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	A	a	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	15	punct	_	_
17	B	b	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	C	c	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	each	each	DT	DT	_	24	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	21	nmod	_	_
24	influences	influence	VBZ	VBZ	_	13	acl:relcl	_	_
25	the	the	DT	DT	_	26	det	_	_
26	level	level	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	tax	tax	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	A	a	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	9	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	21	21	CD	CD	_	7	compound	_	_
7	bp	bp	NN	NN	_	8	amod	_	_
8	repeat	repeat	NN	NN	_	3	nmod	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	strong	strong	JJ	JJ	_	11	amod	_	_
11	homology	homology	NN	NN	_	9	dobj	_	_
12	with	with	IN	IN	_	16	case	_	_
13	previously	previously	RB	RB	_	14	advmod	_	_
14	described	describe	VBN	VBN	_	16	amod	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	sites	site	NNS	NNS	_	11	nmod	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	AP-2	ap-2	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	AP-2	ap-2	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	present	present	JJ	JJ	_	2	ccomp	_	_
8	in	in	IN	IN	_	9	case	_	_
9	T-lymphocytes	t-lymphocyte	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	that	that	IN	IN	_	21	mark	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	21	nsubj	_	_
14	from	from	IN	IN	_	19	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	non-transformed	non-transformed	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	transformed	transform	VBN	VBN	_	16	conj	_	_
19	T-lymphocytes	t-lymphocyte	NNS	NNS	_	13	nmod	_	_
20	specifically	specifically	RB	RB	_	21	advmod	_	_
21	bound	bind	VBD	VBD	_	7	conj	_	_
22	to	to	TO	TO	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	consensus	consensus	NN	NN	_	25	compound	_	_
25	motif	motif	NN	NN	_	21	nmod	_	_
26	for	for	IN	IN	_	27	case	_	_
27	AP-2	ap-2	NN	NN	_	25	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	each	each	DT	DT	_	31	det	_	_
30	21	21	CD	CD	_	31	nummod	_	_
31	bp	bp	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	18	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AP-2	ap-2	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	HTLV-I	htlv-i	NN	NN	_	15	compound	_	_
13	LTR	ltr	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	used	use	VBD	VBD	_	0	root	_	_
19	an	a	DT	DT	_	21	det	_	_
20	AP-2	ap-2	NN	NN	_	21	compound	_	_
21	cDNA	cdna	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	28	case	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	28	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	transient	transient	JJ	JJ	_	27	amod	_	_
27	expression	expression	NN	NN	_	24	conj	_	_
28	assays	assay	NNS	NNS	_	18	nmod	_	_
29	.	.	.	.	_	18	punct	_	_

1	Gel	gel	NN	NN	_	2	compound	_	_
2	retardation	retardation	NN	NN	_	6	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	methylation	methylation	NN	NN	_	5	compound	_	_
5	interference	interference	NN	NN	_	2	conj	_	_
6	studies	study	NNS	NNS	_	7	nsubj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	bacterially	bacterially	RB	RB	_	10	advmod	_	_
10	produced	produce	VBN	VBN	_	11	amod	_	_
11	AP-2	ap-2	NN	NN	_	12	nsubj	_	_
12	bound	bind	VBD	VBD	_	7	ccomp	_	_
13	specifically	specifically	RB	RB	_	14	advmod	_	_
14	and	and	CC	CC	_	12	advmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	high	high	JJ	JJ	_	17	amod	_	_
17	affinity	affinity	NN	NN	_	14	conj	_	_
18	to	to	TO	TO	_	23	case	_	_
19	all	all	DT	DT	_	20	advmod	_	_
20	three	three	CD	CD	_	23	nummod	_	_
21	21	21	CD	CD	_	22	compound	_	_
22	bp	bp	NN	NN	_	23	amod	_	_
23	repeats	repeat	NNS	NNS	_	12	nmod	_	_
24	,	,	,	,	_	12	punct	_	_
25	and	and	CC	CC	_	12	cc	_	_
26	that	that	IN	IN	_	28	mark	_	_
27	it	it	PRP	PRP	_	28	nsubj	_	_
28	required	require	VBD	VBD	_	12	conj	_	_
29	the	the	DT	DT	_	32	det	_	_
30	core	core	NN	NN	_	32	compound	_	_
31	sequence	sequence	NN	NN	_	32	compound	_	_
32	AGGC	aggc	NN	NN	_	28	dobj	_	_
33	for	for	IN	IN	_	35	case	_	_
34	specific	specific	JJ	JJ	_	35	amod	_	_
35	binding	binding	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	Binding	binding	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	AP-2	ap-2	NN	NN	_	1	nmod	_	_
4	prevented	prevent	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	subsequent	subsequent	JJ	JJ	_	7	amod	_	_
7	binding	binding	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	members	member	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CREB/ATF	creb/atf	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	adjacent	adjacent	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	motif	motif	NN	NN	_	7	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	21	21	CD	CD	_	22	compound	_	_
22	bp	bp	NN	NN	_	23	amod	_	_
23	repeat	repeat	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Transfection	transfection	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	an	a	DT	DT	_	6	det	_	_
4	AP-2	ap-2	NN	NN	_	6	compound	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	construct	construct	NN	NN	_	1	nmod	_	_
7	into	into	IN	IN	_	8	case	_	_
8	T-lymphocytes	t-lymphocyte	NNS	NNS	_	1	nmod	_	_
9	activated	activate	VBD	VBD	_	0	root	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HTLV-I	htlv-i	NN	NN	_	15	compound	_	_
15	LTR	ltr	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	nmod:npmod	_	_
3	two	two	CD	CD	_	6	nummod	_	_
4	21	21	CD	CD	_	5	compound	_	_
5	bp	bp	NN	NN	_	6	amod	_	_
6	repeats	repeat	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	AP-2	ap-2	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	mutagenesis	mutagenesis	NN	NN	_	28	nsubj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	AP-2	ap-2	NN	NN	_	22	compound	_	_
20	consensus	consensus	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	sequences	sequence	NNS	NNS	_	16	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	21	21	CD	CD	_	26	compound	_	_
26	bp	bp	NN	NN	_	27	amod	_	_
27	repeats	repeat	NNS	NNS	_	22	nmod	_	_
28	eliminate	eliminate	VBP	VBP	_	8	conj	_	_
29	this	this	DT	DT	_	30	det	_	_
30	activation	activation	NN	NN	_	28	dobj	_	_
31	.	.	.	.	_	8	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Cell	cell	NN	NN	_	2	nmod:npmod	_	_
2	cycle-dependent	cycle-dependent	JJ	JJ	_	3	amod	_	_
3	initiation	initiation	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	lineage-dependent	lineage-dependent	JJ	JJ	_	6	amod	_	_
6	abrogation	abrogation	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	GATA-1	gata-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	pure	pure	JJ	JJ	_	14	amod	_	_
12	differentiating	differentiate	VBG	VBG	_	14	amod	_	_
13	hematopoietic	hematopoietic	JJ	JJ	_	14	amod	_	_
14	progenitors	progenitor	NNS	NNS	_	3	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	programmed	program	VBN	VBN	_	3	amod	_	_
3	activation/repression	activation/repression	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	early	early	JJ	JJ	_	10	amod	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	3	nmod	_	_
11	has	have	VBZ	VBZ	_	15	aux	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	yet	yet	RB	RB	_	15	advmod	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	explored	explore	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	GATA-1	gata-1	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	normal	normal	JJ	JJ	_	10	amod	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	development	development	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	regulates	regulate	VBZ	VBZ	_	6	conj	_	_
13	erythroid-expressed	erythroid-expressed	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	12	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	maturing	mature	VBG	VBG	_	17	amod	_	_
17	erythroblasts	erythroblast	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	GATA-1	gata-1	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	early	early	JJ	JJ	_	9	amod	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	adult	adult	JJ	JJ	_	9	amod	_	_
9	hematopoiesis	hematopoiesis	NN	NN	_	4	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	using	use	VBG	VBG	_	2	advcl	_	_
12	an	a	DT	DT	_	15	det	_	_
13	in	in	FW	FW	_	15	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	system	system	NN	NN	_	11	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	24	nmod	_	_
18	``	``	``	``	_	22	punct	_	_
19	pure	pure	JJ	JJ	_	22	amod	_	_
20	early	early	JJ	JJ	_	22	amod	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	22	amod	_	_
22	progenitors	progenitor	NNS	NNS	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	induced	induce	VBN	VBN	_	15	acl:relcl	_	_
25	to	to	TO	TO	_	29	case	_	_
26	gradual	gradual	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	synchronized	synchronize	VBD	VBD	_	26	conj	_	_
29	differentiation	differentiation	NN	NN	_	24	nmod	_	_
30	selectively	selectively	RB	RB	_	24	advmod	_	_
31	along	along	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	erythroid	erythroid	JJ	JJ	_	36	amod	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	33	conj	_	_
36	pathway	pathway	NN	NN	_	24	nmod	_	_
37	by	by	IN	IN	_	39	case	_	_
38	differential	differential	JJ	JJ	_	39	amod	_	_
39	treatment	treatment	NN	NN	_	24	nmod	_	_
40	with	with	IN	IN	_	43	case	_	_
41	hematopoietic	hematopoietic	JJ	JJ	_	43	amod	_	_
42	growth	growth	NN	NN	_	43	compound	_	_
43	factors	factor	NNS	NNS	_	39	nmod	_	_
44	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GATA-1	gata-1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	13	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	though	though	IN	IN	_	7	mark	_	_
6	virtually	virtually	RB	RB	_	7	advmod	_	_
7	silent	silent	JJ	JJ	_	3	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	quiescent	quiescent	JJ	JJ	_	10	amod	_	_
10	progenitors	progenitor	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	activated	activate	VBN	VBN	_	0	root	_	_
14	after	after	IN	IN	_	15	case	_	_
15	entrance	entrance	NN	NN	_	13	nmod	_	_
16	into	into	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	cycle	cycle	NN	NN	_	15	nmod	_	_
20	upon	upon	IN	IN	_	21	case	_	_
21	stimulation	stimulation	NN	NN	_	13	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	hematopoietic	hematopoietic	JJ	JJ	_	25	amod	_	_
24	growth	growth	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Subsequently	subsequently	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	increasing	increase	VBG	VBG	_	4	amod	_	_
4	expression	expression	NN	NN	_	9	nsubj	_	_
5	along	along	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
8	pathway	pathway	NN	NN	_	4	nmod	_	_
9	contrasts	contrast	VBZ	VBZ	_	0	root	_	_
10	with	with	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	abrupt	abrupt	JJ	JJ	_	13	amod	_	_
13	downregulation	downregulation	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	17	amod	_	_
17	lineage	lineage	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	microenvironment-directed	microenvironment-directed	JJ	JJ	_	8	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	two-step	two-step	JJ	JJ	_	5	dep	_	_
8	model	model	NN	NN	_	3	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	GATA-1	gata-1	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	differentiating	differentiate	VBG	VBG	_	15	amod	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	8	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	involves	involve	VBZ	VBZ	_	8	acl:relcl	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	i	i	LS	LS	_	22	dep	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	cycle-dependent	cycle-dependent	JJ	JJ	_	22	amod	_	_
22	initiation	initiation	NN	NN	_	17	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	ii	ii	LS	LS	_	28	dep	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	lineage-dependent	lineage-dependent	JJ	JJ	_	28	amod	_	_
28	maintenance	maintenance	NN	NN	_	22	conj	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	suppression	suppression	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	3	punct	_	_

1	Hypothetically	hypothetically	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	on/off	on/off	JJ	JJ	_	4	amod	_	_
4	switches	switch	NNS	NNS	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	lineage-restricted	lineage-restricted	JJ	JJ	_	7	amod	_	_
7	transactivators	transactivator	NNS	NNS	_	4	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	underlie	underlie	VB	VB	_	0	root	_	_
10	the	the	DT	DT	_	13	det	_	_
11	binary	binary	JJ	JJ	_	13	amod	_	_
12	fate	fate	NN	NN	_	13	compound	_	_
13	decisions	decision	NNS	NNS	_	9	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	hematopoietic	hematopoietic	JJ	JJ	_	16	amod	_	_
16	progenitors	progenitor	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Age-related	age-related	JJ	JJ	_	3	amod	_	_
3	changes	change	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	mineralocorticoid	mineralocorticoid	NN	NN	_	5	conj	_	_
8	receptors	receptor	NNS	NNS	_	3	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	healthy	healthy	JJ	JJ	_	13	amod	_	_
13	persons	person	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	patients	patient	NNS	NNS	_	13	conj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	hypertension	hypertension	NN	NN	_	15	nmod	_	_
18	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	number	number	NN	NN	_	21	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
16	blood	blood	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	healthy	healthy	JJ	JJ	_	20	amod	_	_
19	elderly	elderly	JJ	JJ	_	20	amod	_	_
20	subjects	subject	NNS	NNS	_	16	nmod	_	_
21	increases	increase	VBZ	VBZ	_	4	ccomp	_	_
22	,	,	,	,	_	21	punct	_	_
23	while	while	IN	IN	_	29	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	number	number	NN	NN	_	29	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	mineralocorticoid	mineralocorticoid	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	25	nmod	_	_
29	decreases	decrease	VBZ	VBZ	_	21	advcl	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	hormone-receptor	hormone-receptor	NN	NN	_	5	compound	_	_
5	interactions	interaction	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	hypertension	hypertension	NN	NN	_	2	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	0	root	_	_
10	:	:	:	:	_	9	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	19	nsubj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	mineralocorticoid	mineralocorticoid	NN	NN	_	14	conj	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	12	nmod	_	_
19	grows	grow	VBZ	VBZ	_	9	parataxis	_	_
20	in	in	IN	IN	_	22	case	_	_
21	hypertensive	hypertensive	JJ	JJ	_	22	amod	_	_
22	patients	patient	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	19	punct	_	_

1	Still	still	RB	RB	_	12	advmod	_	_
2	a	a	DT	DT	_	5	det	_	_
3	more	more	RBR	RBR	_	4	advmod	_	_
4	essential	essential	JJ	JJ	_	5	amod	_	_
5	rise	rise	NN	NN	_	12	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	receptors	receptor	NNS	NNS	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	mid-age	mid-age	JJ	JJ	_	16	amod	_	_
15	hypertensive	hypertensive	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	12	nmod	_	_
17	than	than	IN	IN	_	20	case	_	_
18	in	in	IN	IN	_	20	case	_	_
19	elderly	elderly	JJ	JJ	_	20	amod	_	_
20	ones	one	NNS	NNS	_	12	advcl	_	_
21	.	.	.	.	_	12	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	footprint	footprint	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	HLA-DRA	hla-dra	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	4	nmod	_	_
10	:	:	:	:	_	4	punct	_	_
11	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
12	interaction	interaction	NN	NN	_	4	dep	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	octamer	octamer	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	up-regulation	up-regulation	NN	NN	_	12	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	X	x	NN	NN	_	22	compound	_	_
21	box	box	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	18	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	interferon	interferon	NN	NN	_	25	compound	_	_
25	gamma	gamma	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	Analysis	analysis	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	11	case	_	_
3	the	the	DT	DT	_	11	det	_	_
4	major	major	JJ	JJ	_	11	amod	_	_
5	histocompatibility	histocompatibility	NN	NN	_	11	compound	_	_
6	complex	complex	NN	NN	_	11	compound	_	_
7	class	class	NN	NN	_	11	compound	_	_
8	II	ii	CD	CD	_	11	nummod	_	_
9	gene	gene	NN	NN	_	11	compound	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	DRA	dra	NN	NN	_	1	nmod	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	previously	previously	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	at	at	IN	IN	_	16	case	_	_
16	least	least	JJS	JJS	_	17	nmod:npmod	_	_
17	five	five	CD	CD	_	19	nummod	_	_
18	cis-acting	cis-acting	JJ	JJ	_	19	amod	_	_
19	regions	region	NNS	NNS	_	14	dobj	_	_
20	required	require	VBN	VBN	_	19	acl	_	_
21	for	for	IN	IN	_	23	case	_	_
22	maximal	maximal	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	DRA	dra	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	protein-DNA	protein-dna	JJ	JJ	_	9	amod	_	_
9	interactions	interaction	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	intact	intact	JJ	JJ	_	13	amod	_	_
13	cell	cell	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	mediate	mediate	VB	VB	_	6	acl:relcl	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	7	dep	_	_
2	in	in	FW	FW	_	5	amod	_	_
3	vivo	vivo	FW	FW	_	2	dep	_	_
4	genomic	genomic	JJ	JJ	_	5	amod	_	_
5	footprinting	footprinting	NN	NN	_	1	dobj	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	interactions	interaction	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	8	nmod	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	octamer	octamer	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	7	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	24	det	_	_
18	Y	y	NN	NN	_	24	compound	_	_
19	,	,	,	,	_	18	punct	_	_
20	X1	x1	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	X2	x2	NN	NN	_	18	conj	_	_
24	boxes	box	NNS	NNS	_	15	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	Class	class	NN	NN	_	6	compound	_	_
2	II	ii	CD	CD	_	6	nummod	_	_
3	antigen	antigen	NN	NN	_	6	compound	_	_
4	expressing	express	VBG	VBG	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	7	nsubj	_	_
7	maintained	maintain	VBD	VBD	_	0	root	_	_
8	contacts	contact	NNS	NNS	_	7	dobj	_	_
9	identical	identical	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	while	while	IN	IN	_	19	mark	_	_
15	class	class	NN	NN	_	16	nmod:npmod	_	_
16	II-negative	ii-negative	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	19	nsubj	_	_
19	exhibited	exhibit	VBD	VBD	_	7	advcl	_	_
20	no	no	DT	DT	_	21	neg	_	_
21	interactions	interaction	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	octamer	octamer	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	occupied	occupy	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	required	require	VBN	VBN	_	10	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	maximal	maximal	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	8	nsubj	_	_
2	is	be	VBZ	VBZ	_	8	cop	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	likely	likely	RB	RB	_	8	advmod	_	_
5	due	due	JJ	JJ	_	8	case	_	_
6	to	to	TO	TO	_	5	mwe	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	lymphoid-specific	lymphoid-specific	JJ	JJ	_	13	amod	_	_
12	OTF-2	otf-2	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	10	det	_	_
5	class	class	NN	NN	_	6	nmod:npmod	_	_
6	II-positive	ii-positive	JJ	JJ	_	10	amod	_	_
7	nonlymphoid	nonlymphoid	JJ	JJ	_	10	amod	_	_
8	glioblastoma	glioblastoma	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	13	nsubj	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	exhibit	exhibit	VB	VB	_	0	root	_	_
14	interactions	interaction	NNS	NNS	_	13	dobj	_	_
15	at	at	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	octamer	octamer	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	despite	despite	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	ubiquitous	ubiquitous	JJ	JJ	_	26	amod	_	_
25	OTF-1	otf-1	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	13	cc	_	_
28	an	a	DT	DT	_	31	det	_	_
29	open	open	JJ	JJ	_	31	amod	_	_
30	binding	bind	VBG	VBG	_	31	amod	_	_
31	site	site	NN	NN	_	13	conj	_	_
32	.	.	.	.	_	13	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	DRA	dra	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	discriminates	discriminate	VBZ	VBZ	_	0	root	_	_
7	against	against	IN	IN	_	9	case	_	_
8	OTF-1	otf-1	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	level	level	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	glioblastoma	glioblastoma	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	6	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Interferon	interferon	NN	NN	_	2	compound	_	_
2	gamma	gamma	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	expression	expression	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	this	this	DT	DT	_	11	det	_	_
9	glioblastoma	glioblastoma	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	3	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	,	,	,	,	_	3	punct	_	_
14	in	in	IN	IN	_	15	case	_	_
15	parallel	parallel	NN	NN	_	17	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	up-regulates	up-regulate	VBZ	VBZ	_	3	conj	_	_
18	X1	x1	NN	NN	_	23	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	X2	x2	NN	NN	_	18	conj	_	_
21	box	box	NN	NN	_	23	compound	_	_
22	protein-DNA	protein-dna	JJ	JJ	_	23	amod	_	_
23	interactions	interaction	NNS	NNS	_	17	dobj	_	_
24	,	,	,	,	_	17	punct	_	_
25	while	while	IN	IN	_	29	mark	_	_
26	all	all	DT	DT	_	28	det	_	_
27	other	other	JJ	JJ	_	28	amod	_	_
28	interactions	interaction	NNS	NNS	_	29	nsubj	_	_
29	remain	remain	VBP	VBP	_	17	advcl	_	_
30	unchanged	unchanged	JJ	JJ	_	29	xcomp	_	_
31	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	interferon	interferon	NN	NN	_	6	compound	_	_
6	gamma	gamma	NN	NN	_	7	nsubj	_	_
7	functions	function	VBZ	VBZ	_	3	ccomp	_	_
8	on	on	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	poised	poise	VBN	VBN	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	altering	alter	VBG	VBG	_	7	advcl	_	_
14	weak	weak	JJ	JJ	_	17	amod	_	_
15	,	,	,	,	_	17	punct	_	_
16	nonproductive	nonproductive	JJ	JJ	_	17	amod	_	_
17	interactions	interaction	NNS	NNS	_	13	dobj	_	_
18	at	at	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	X	x	NN	NN	_	21	compound	_	_
21	boxes	box	NNS	NNS	_	17	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	strong	strong	JJ	JJ	_	24	amod	_	_
24	interactions	interaction	NNS	NNS	_	13	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	direct	direct	JJ	JJ	_	7	amod	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	vivo	vivo	FW	FW	_	5	dep	_	_
7	evidence	evidence	NN	NN	_	3	dobj	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	suggest	suggest	VB	VB	_	7	acl	_	_
11	that	that	IN	IN	_	22	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	modulation	modulation	NN	NN	_	22	nsubj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	X1	x1	NN	NN	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	X2	x2	NN	NN	_	15	conj	_	_
18	interactions	interaction	NNS	NNS	_	13	nmod	_	_
19	is	be	VBZ	VBZ	_	22	cop	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	constituent	constituent	NN	NN	_	10	ccomp	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	interferon	interferon	NN	NN	_	28	compound	_	_
26	gamma	gamma	NN	NN	_	28	compound	_	_
27	induction	induction	NN	NN	_	28	compound	_	_
28	pathway	pathway	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Simple	simple	JJ	JJ	_	2	amod	_	_
2	derivation	derivation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	TFIID-dependent	tfiid-dependent	JJ	JJ	_	9	amod	_	_
5	RNA	rna	NN	NN	_	9	compound	_	_
6	polymerase	polymerase	NN	NN	_	9	compound	_	_
7	II	ii	CD	CD	_	9	nummod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	systems	system	NNS	NNS	_	2	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	Schizosaccharomyces	schizosaccharomyces	FW	FW	_	12	compound	_	_
12	pombe	pombe	FW	FW	_	2	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	organisms	organism	NNS	NNS	_	12	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	and	and	CC	CC	_	2	cc	_	_
18	factors	factor	NNS	NNS	_	2	conj	_	_
19	required	require	VBN	VBN	_	18	acl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Resolution	resolution	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	whole	whole	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	extract	extract	NN	NN	_	1	nmod	_	_
6	through	through	IN	IN	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	chromatographic	chromatographic	JJ	JJ	_	9	amod	_	_
9	steps	step	NNS	NNS	_	1	nmod	_	_
10	yields	yield	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	single	single	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	fraction	fraction	NN	NN	_	10	dobj	_	_
15	requiring	require	VBG	VBG	_	14	acl	_	_
16	only	only	RB	RB	_	18	advmod	_	_
17	the	the	DT	DT	_	18	det	_	_
18	addition	addition	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	TFIID	tfiid	NN	NN	_	18	nmod	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	initiation	initiation	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	transcription	transcription	NN	NN	_	23	nmod	_	_
26	at	at	IN	IN	_	30	case	_	_
27	RNA	rna	NN	NN	_	30	compound	_	_
28	polymerase	polymerase	NN	NN	_	30	compound	_	_
29	II	ii	CD	CD	_	30	nummod	_	_
30	promoters	promoter	NNS	NNS	_	23	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	approach	approach	NN	NN	_	3	nsubj	_	_
3	allows	allow	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	convenient	convenient	JJ	JJ	_	6	amod	_	_
6	generation	generation	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	RNA	rna	NN	NN	_	12	compound	_	_
9	polymerase	polymerase	NN	NN	_	12	compound	_	_
10	II	ii	CD	CD	_	12	nummod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	systems	system	NNS	NNS	_	6	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	Saccharomyces	saccharomyces	FW	FW	_	15	compound	_	_
15	cerevisiae	cerevisiae	FW	FW	_	6	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	Schizosaccharomyces	schizosaccharomyces	FW	FW	_	22	compound	_	_
22	pombe	pombe	FW	FW	_	15	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	TFIIDs	tfiid	NNS	NNS	_	7	nsubj	_	_
2	from	from	IN	IN	_	5	case	_	_
3	all	all	DT	DT	_	5	det	_	_
4	three	three	CD	CD	_	5	nummod	_	_
5	organisms	organism	NNS	NNS	_	1	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	interchangeable	interchangeable	JJ	JJ	_	0	root	_	_
8	among	among	IN	IN	_	11	case	_	_
9	all	all	DT	DT	_	11	det	_	_
10	three	three	CD	CD	_	11	nummod	_	_
11	systems	system	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	S.	s.	FW	FW	_	3	compound	_	_
3	cerevisiae	cerevisiae	FW	FW	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Sch.	sch.	FW	FW	_	6	compound	_	_
6	pombe	pombe	FW	FW	_	3	conj	_	_
7	systems	system	NNS	NNS	_	8	nsubj	_	_
8	support	support	VBP	VBP	_	0	root	_	_
9	effects	effect	NNS	NNS	_	8	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	acidic	acidic	JJ	JJ	_	13	amod	_	_
12	activator	activator	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	provided	provide	VBN	VBN	_	24	mark	_	_
16	a	a	DT	DT	_	19	det	_	_
17	further	further	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	fraction	fraction	NN	NN	_	24	nsubjpass	_	_
20	from	from	IN	IN	_	22	case	_	_
21	S.	s.	FW	FW	_	22	compound	_	_
22	cerevisiae	cerevisiae	FW	FW	_	19	nmod	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	supplied	supply	VBN	VBN	_	8	advcl	_	_
25	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	further	further	JJ	JJ	_	3	amod	_	_
3	fraction	fraction	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	distinct	distinct	JJ	JJ	_	0	root	_	_
6	from	from	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mediator	mediator	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	described	describe	VBN	VBN	_	8	acl	_	_
13	previously	previously	RB	RB	_	12	advmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	represents	represent	VBZ	VBZ	_	5	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	second	second	JJ	JJ	_	18	amod	_	_
18	component	component	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	24	case	_	_
20	addition	addition	NN	NN	_	24	dep	_	_
21	to	to	TO	TO	_	24	case	_	_
22	general	general	JJ	JJ	_	24	amod	_	_
23	initiation	initiation	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	15	nmod	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	facilitate	facilitate	VB	VB	_	24	acl:relcl	_	_
28	a	a	DT	DT	_	29	det	_	_
29	response	response	NN	NN	_	27	dobj	_	_
30	to	to	TO	TO	_	32	case	_	_
31	acidic	acidic	JJ	JJ	_	32	amod	_	_
32	activators	activator	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	nmod:npmod	_	_
2	B-dependent	b-dependent	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
7	B	b	NN	NN	_	11	compound	_	_
8	p50	p50	NN	NN	_	11	compound	_	_
9	subunit	subunit	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	3	nmod	_	_
12	underlies	underlie	VBZ	VBZ	_	0	root	_	_
13	self-perpetuation	self-perpetuation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	13	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	27	nsubjpass	_	_
4	underlying	underlie	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	8	det	_	_
6	sustained	sustained	JJ	JJ	_	8	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	translocation	translocation	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	8	nmod	_	_
12	observed	observe	VBN	VBN	_	8	acl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	U937	u937	NN	NN	_	16	compound	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	chronically	chronically	RB	RB	_	18	advmod	_	_
18	infected	infect	VBN	VBN	_	16	dep	_	_
19	with	with	IN	IN	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
22	virus	virus	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	HIV	hiv	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	studied	study	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	2	nmod	_	_
6	regulating	regulate	VBG	VBG	_	2	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	synthesis	synthesis	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	p105	p105	NN	NN	_	12	compound	_	_
12	precursor	precursor	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	p50	p50	NN	NN	_	18	compound	_	_
18	subunit	subunit	NN	NN	_	12	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	enhanced	enhance	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	Deletions	deletion	NNS	NNS	_	5	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	promoter	promoter	NN	NN	_	1	nmod	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	this	this	DT	DT	_	8	det	_	_
8	upregulation	upregulation	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	5	ccomp	_	_
11	through	through	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B-	b-	NN	NN	_	10	nmod	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	14	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	AP-1-binding	ap-1-binding	JJ	JJ	_	14	conj	_	_
19	motif	motif	NN	NN	_	14	dep	_	_
20	,	,	,	,	_	10	punct	_	_
21	by	by	IN	IN	_	25	case	_	_
22	bona	bona	FW	FW	_	25	amod	_	_
23	fide	fide	FW	FW	_	22	dep	_	_
24	p50/p65	p50/p65	NN	NN	_	25	compound	_	_
25	heterodimers	heterodimer	NNS	NNS	_	10	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cytosolic	cytosolic	JJ	JJ	_	4	amod	_	_
4	extracts	extract	NNS	NNS	_	1	nmod	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	increased	increase	VBN	VBN	_	5	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	HIV-infected	hiv-infected	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	8	case	_	_
2	contrast	contrast	NN	NN	_	8	dep	_	_
3	to	to	TO	TO	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	transient	transient	JJ	JJ	_	8	amod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	25	nmod	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	ester	ester	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	25	punct	_	_
14	the	the	DT	DT	_	18	det	_	_
15	permanent	permanent	JJ	JJ	_	18	amod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	translocation	translocation	NN	NN	_	25	nsubj	_	_
19	induced	induce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	HIV	hiv	NN	NN	_	22	compound	_	_
22	infection	infection	NN	NN	_	19	nmod	_	_
23	was	be	VBD	VBD	_	25	cop	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	dependent	dependent	JJ	JJ	_	0	root	_	_
26	on	on	IN	IN	_	28	case	_	_
27	PKC	pkc	NN	NN	_	28	compound	_	_
28	isoenzymes	isoenzyme	NNS	NNS	_	25	nmod	_	_
29	alpha	alpha	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	beta	beta	NN	NN	_	29	conj	_	_
32	as	as	IN	IN	_	33	mark	_	_
33	shown	show	VBN	VBN	_	25	advcl	_	_
34	by	by	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	use	use	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	specific	specific	JJ	JJ	_	40	amod	_	_
40	inhibitor	inhibitor	NN	NN	_	36	nmod	_	_
41	(	(	-LRB-	-LRB-	_	43	punct	_	_
42	GF	gf	NN	NN	_	43	compound	_	_
43	109203X	109203x	NN	NN	_	40	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	during	during	IN	IN	_	8	case	_	_
6	chronic	chronic	JJ	JJ	_	8	amod	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	20	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	U937	u937	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	20	punct	_	_
13	continuous	continuous	JJ	JJ	_	19	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
15	B	b	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	p50/p65	p50/p65	NN	NN	_	19	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	translocation	translocation	NN	NN	_	20	nsubj	_	_
20	results	result	VBZ	VBZ	_	3	ccomp	_	_
21	in	in	IN	IN	_	24	case	_	_
22	p105	p105	NN	NN	_	24	compound	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	upregulation	upregulation	NN	NN	_	20	nmod	_	_
25	with	with	IN	IN	_	30	case	_	_
26	subsequent	subsequent	JJ	JJ	_	30	amod	_	_
27	cytosolic	cytosolic	JJ	JJ	_	30	amod	_	_
28	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	accumulation	accumulation	NN	NN	_	24	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	ready	ready	JJ	JJ	_	30	amod	_	_
33	for	for	IN	IN	_	35	case	_	_
34	further	further	JJ	JJ	_	35	amod	_	_
35	translocation	translocation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	HIV-mediated	hiv-mediated	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	4	nsubj	_	_
4	results	result	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	self-perpetuating	self-perpetuating	JJ	JJ	_	8	amod	_	_
8	loop	loop	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	development	development	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	responsive	responsive	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	work	work	NN	NN	_	7	nsubj	_	_
3	reviewed	review	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	article	article	NN	NN	_	3	nmod	_	_
7	separates	separate	VBZ	VBZ	_	0	root	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	development	development	NN	NN	_	7	dobj	_	_
11	into	into	IN	IN	_	13	case	_	_
12	four	four	CD	CD	_	13	nummod	_	_
13	phases	phase	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	First	first	JJ	JJ	_	2	dep	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	expansion	expansion	NN	NN	_	5	compound	_	_
5	phase	phase	NN	NN	_	2	nsubj	_	_
6	prior	prior	RB	RB	_	9	case	_	_
7	to	to	TO	TO	_	6	mwe	_	_
8	TCR	tcr	NN	NN	_	9	compound	_	_
9	rearrangement	rearrangement	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	appears	appear	VBZ	VBZ	_	5	acl:relcl	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	correlated	correlate	VBN	VBN	_	12	xcomp	_	_
16	with	with	IN	IN	_	17	case	_	_
17	programming	programming	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	at	at	IN	IN	_	20	case	_	_
20	least	least	JJS	JJS	_	21	nmod:npmod	_	_
21	some	some	DT	DT	_	23	nummod	_	_
22	response	response	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	17	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	inducibility	inducibility	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phase	phase	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	occur	occur	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	some	some	DT	DT	_	7	det	_	_
7	extent	extent	NN	NN	_	4	nmod	_	_
8	outside	outside	IN	IN	_	4	advmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	thymus	thymus	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	profound	profound	JJ	JJ	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	deficit	deficit	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	nude	nude	JJ	JJ	_	10	amod	_	_
10	mice	mouse	NNS	NNS	_	7	nmod	_	_
11	indicates	indicate	VBZ	VBZ	_	0	root	_	_
12	that	that	IN	IN	_	21	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	thymus	thymus	NN	NN	_	21	nsubj	_	_
15	is	be	VBZ	VBZ	_	21	cop	_	_
16	by	by	IN	IN	_	17	case	_	_
17	far	far	RB	RB	_	21	advcl	_	_
18	the	the	DT	DT	_	21	det	_	_
19	most	most	RBS	RBS	_	20	advmod	_	_
20	potent	potent	JJ	JJ	_	21	amod	_	_
21	site	site	NN	NN	_	11	ccomp	_	_
22	for	for	IN	IN	_	23	mark	_	_
23	inducing	induce	VBG	VBG	_	21	acl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expansion	expansion	NN	NN	_	23	dobj	_	_
26	per	per	FW	FW	_	27	compound	_	_
27	se	se	FW	FW	_	23	advmod	_	_
28	,	,	,	,	_	21	punct	_	_
29	even	even	RB	RB	_	34	advmod	_	_
30	if	if	IN	IN	_	34	mark	_	_
31	other	other	JJ	JJ	_	32	amod	_	_
32	sites	site	NNS	NNS	_	34	nsubj	_	_
33	can	can	MD	MD	_	34	aux	_	_
34	induce	induce	VB	VB	_	21	advcl	_	_
35	some	some	DT	DT	_	37	det	_	_
36	response	response	NN	NN	_	37	compound	_	_
37	acquisition	acquisition	NN	NN	_	34	dobj	_	_
38	.	.	.	.	_	11	punct	_	_

1	Second	second	JJ	JJ	_	2	dep	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	controlled	controlled	JJ	JJ	_	5	amod	_	_
5	phase	phase	NN	NN	_	2	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	TCR	tcr	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	rearrangement	rearrangement	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	details	detail	NNS	NNS	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	2	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	selects	select	VBZ	VBZ	_	6	acl:relcl	_	_
9	particular	particular	JJ	JJ	_	10	amod	_	_
10	loci	locus	NNS	NNS	_	8	dobj	_	_
11	for	for	IN	IN	_	12	case	_	_
12	rearrangement	rearrangement	NN	NN	_	10	nmod	_	_
13	are	be	VBP	VBP	_	16	auxpass	_	_
14	still	still	RB	RB	_	16	advmod	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	known	know	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	seems	seem	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	rearrangement	rearrangement	NN	NN	_	19	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	TCR	tcr	NN	NN	_	10	compound	_	_
9	gamma	gamma	NN	NN	_	10	compound	_	_
10	loci	locus	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	gamma	gamma	NN	NN	_	15	compound	_	_
14	delta	delta	NN	NN	_	15	compound	_	_
15	lineage	lineage	NN	NN	_	5	nmod	_	_
16	may	may	MD	MD	_	19	aux	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	always	always	RB	RB	_	19	advmod	_	_
19	take	take	VB	VB	_	2	ccomp	_	_
20	place	place	NN	NN	_	19	dobj	_	_
21	at	at	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	developmental	developmental	JJ	JJ	_	24	amod	_	_
24	stage	stage	NN	NN	_	19	nmod	_	_
25	strictly	strictly	RB	RB	_	26	advmod	_	_
26	equivalent	equivalent	JJ	JJ	_	24	amod	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	rearrangement	rearrangement	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	TCR	tcr	NN	NN	_	32	compound	_	_
32	beta	beta	NN	NN	_	29	nmod	_	_
33	in	in	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	alpha	alpha	NN	NN	_	37	compound	_	_
36	beta	beta	NN	NN	_	37	compound	_	_
37	lineage	lineage	NN	NN	_	29	nmod	_	_
38	,	,	,	,	_	2	punct	_	_
39	and	and	CC	CC	_	2	cc	_	_
40	it	it	PRP	PRP	_	43	nsubj	_	_
41	is	be	VBZ	VBZ	_	43	cop	_	_
42	not	not	RB	RB	_	43	neg	_	_
43	clear	clear	JJ	JJ	_	2	conj	_	_
44	just	just	RB	RB	_	46	advmod	_	_
45	how	how	WRB	WRB	_	46	advmod	_	_
46	early	early	RB	RB	_	50	advmod	_	_
47	the	the	DT	DT	_	49	det	_	_
48	two	two	CD	CD	_	49	nummod	_	_
49	lineages	lineage	NNS	NNS	_	50	nsubj	_	_
50	diverge	diverge	VBP	VBP	_	43	ccomp	_	_
51	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	TCR	tcr	NN	NN	_	6	compound	_	_
4	alpha	alpha	NN	NN	_	6	compound	_	_
5	beta	beta	NN	NN	_	6	compound	_	_
6	lineage	lineage	NN	NN	_	16	nmod	_	_
7	,	,	,	,	_	16	punct	_	_
8	however	however	RB	RB	_	16	advmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	the	the	DT	DT	_	14	det	_	_
11	final	final	JJ	JJ	_	14	amod	_	_
12	gene	gene	NN	NN	_	14	compound	_	_
13	rearrangement	rearrangement	NN	NN	_	14	compound	_	_
14	events	event	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	accompanied	accompany	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	rapid	rapid	JJ	JJ	_	19	amod	_	_
19	proliferation	proliferation	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	an	a	DT	DT	_	22	det	_	_
22	interruption	interruption	NN	NN	_	19	conj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	cellular	cellular	JJ	JJ	_	27	amod	_	_
25	response	response	NN	NN	_	27	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	inducibility	inducibility	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	loss	loss	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	conventional	conventional	JJ	JJ	_	5	amod	_	_
5	responsiveness	responsiveness	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	probably	probably	RB	RB	_	8	advmod	_	_
8	caused	cause	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	alterations	alteration	NNS	NNS	_	8	nmod	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	signaling	signaling	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	may	may	MD	MD	_	21	aux	_	_
19	be	be	VB	VB	_	21	cop	_	_
20	a	a	DT	DT	_	21	det	_	_
21	manifestation	manifestation	NN	NN	_	8	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	physiological	physiological	JJ	JJ	_	25	amod	_	_
25	state	state	NN	NN	_	21	nmod	_	_
26	that	that	WDT	WDT	_	29	nsubj	_	_
27	is	be	VBZ	VBZ	_	29	cop	_	_
28	a	a	DT	DT	_	29	det	_	_
29	precondition	precondition	NN	NN	_	25	acl:relcl	_	_
30	for	for	IN	IN	_	31	case	_	_
31	selection	selection	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Third	third	JJ	JJ	_	2	dep	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	complex	complex	JJ	JJ	_	5	amod	_	_
5	process	process	NN	NN	_	2	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	selection	selection	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	peripheral	peripheral	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	undergo	undergo	VB	VB	_	36	advcl	_	_
7	forms	form	NNS	NNS	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	positive	positive	JJ	JJ	_	10	amod	_	_
10	selection	selection	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	10	punct	_	_
12	by	by	IN	IN	_	15	case	_	_
13	antigen-driven	antigen-driven	JJ	JJ	_	15	amod	_	_
14	clonal	clonal	JJ	JJ	_	15	amod	_	_
15	expansion	expansion	NN	NN	_	10	nmod	_	_
16	)	)	-RRB-	-RRB-	_	10	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	negative	negative	JJ	JJ	_	19	amod	_	_
19	selection	selection	NN	NN	_	10	conj	_	_
20	(	(	-LRB-	-LRB-	_	19	punct	_	_
21	by	by	IN	IN	_	23	case	_	_
22	abortive	abortive	JJ	JJ	_	23	amod	_	_
23	stimulation	stimulation	NN	NN	_	19	nmod	_	_
24	leading	lead	VBG	VBG	_	23	acl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	anergy	anergy	NN	NN	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	death	death	NN	NN	_	26	conj	_	_
29	)	)	-RRB-	-RRB-	_	19	punct	_	_
30	,	,	,	,	_	36	punct	_	_
31	neither	neither	DT	DT	_	36	nsubj	_	_
32	is	be	VBZ	VBZ	_	36	cop	_	_
33	exactly	exactly	RB	RB	_	35	advmod	_	_
34	the	the	DT	DT	_	35	det	_	_
35	same	same	JJ	JJ	_	36	amod	_	_
36	phenomenon	phenomenon	NN	NN	_	0	root	_	_
37	that	that	WDT	WDT	_	38	nsubj	_	_
38	occurs	occur	VBZ	VBZ	_	36	acl:relcl	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	thymic	thymic	JJ	JJ	_	42	amod	_	_
42	cortex	cortex	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	36	punct	_	_

1	Negative	negative	JJ	JJ	_	2	amod	_	_
2	selection	selection	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cortex	cortex	NN	NN	_	2	nmod	_	_
6	appears	appear	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	11	mark	_	_
8	be	be	VB	VB	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	suicidal	suicidal	JJ	JJ	_	11	amod	_	_
11	inversion	inversion	NN	NN	_	6	xcomp	_	_
12	of	of	IN	IN	_	14	case	_	_
13	antigen	antigen	NN	NN	_	14	compound	_	_
14	responsiveness	responsiveness	NN	NN	_	11	nmod	_	_
15	:	:	:	:	_	6	punct	_	_
16	instead	instead	RB	RB	_	18	mark	_	_
17	of	of	IN	IN	_	16	mwe	_	_
18	turning	turn	VBG	VBG	_	26	advcl	_	_
19	on	on	IN	IN	_	18	compound:prt	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	dobj	_	_
22	,	,	,	,	_	26	punct	_	_
23	the	the	DT	DT	_	25	det	_	_
24	activated	activate	VBN	VBN	_	25	amod	_	_
25	cell	cell	NN	NN	_	26	nsubj	_	_
26	destroys	destroy	VBZ	VBZ	_	6	parataxis	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	own	own	JJ	JJ	_	29	amod	_	_
29	chromatin	chromatin	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	14	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	need	need	VBP	VBP	_	2	acl:relcl	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	4	xcomp	_	_
8	for	for	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	response	response	NN	NN	_	7	nmod	_	_
11	are	be	VBP	VBP	_	14	auxpass	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	yet	yet	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	it	it	PRP	PRP	_	21	nsubj	_	_
18	is	be	VBZ	VBZ	_	21	cop	_	_
19	unquestionably	unquestionably	RB	RB	_	21	advmod	_	_
20	a	a	DT	DT	_	21	det	_	_
21	form	form	NN	NN	_	14	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	interesting	interesting	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	humans	human	NNS	NNS	_	17	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	rats	rat	NNS	NNS	_	6	conj	_	_
9	,	,	,	,	_	17	punct	_	_
10	cortical	cortical	JJ	JJ	_	11	amod	_	_
11	thymocytes	thymocyte	NNS	NNS	_	17	nsubj	_	_
12	undergoing	undergo	VBG	VBG	_	11	acl	_	_
13	negative	negative	JJ	JJ	_	14	amod	_	_
14	selection	selection	NN	NN	_	12	dobj	_	_
15	can	can	MD	MD	_	17	aux	_	_
16	still	still	RB	RB	_	17	advmod	_	_
17	induce	induce	VB	VB	_	3	ccomp	_	_
18	IL-2R	il-2r	NN	NN	_	20	compound	_	_
19	alpha	alpha	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	even	even	RB	RB	_	24	advmod	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	rescued	rescue	VBN	VBN	_	17	conj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vitro	vitro	FW	FW	_	24	advmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	if	if	IN	IN	_	32	mark	_	_
29	exogenous	exogenous	JJ	JJ	_	30	amod	_	_
30	IL-2	il-2	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	provided	provide	VBN	VBN	_	17	advcl	_	_
33	.	.	.	.	_	3	punct	_	_

1	Perhaps	perhaps	RB	RB	_	5	advmod	_	_
2	murine	murine	JJ	JJ	_	3	amod	_	_
3	thymocytes	thymocyte	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	denied	deny	VBN	VBN	_	0	root	_	_
6	this	this	DT	DT	_	7	det	_	_
7	form	form	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	rescue	rescue	NN	NN	_	7	nmod	_	_
10	because	because	IN	IN	_	12	mark	_	_
11	they	they	PRP	PRP	_	12	nsubj	_	_
12	shut	shut	VBD	VBD	_	5	advcl	_	_
13	off	off	RP	RP	_	12	compound:prt	_	_
14	IL-2R	il-2r	NN	NN	_	17	compound	_	_
15	beta	beta	NN	NN	_	17	compound	_	_
16	chain	chain	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	12	dobj	_	_
18	at	at	IN	IN	_	21	case	_	_
19	an	a	DT	DT	_	21	det	_	_
20	earlier	earlier	JJR	JJR	_	21	amod	_	_
21	stage	stage	NN	NN	_	12	nmod	_	_
22	or	or	CC	CC	_	12	cc	_	_
23	because	because	IN	IN	_	29	mark	_	_
24	they	they	PRP	PRP	_	29	nsubj	_	_
25	may	may	MD	MD	_	29	aux	_	_
26	be	be	VB	VB	_	29	cop	_	_
27	uncommonly	uncommonly	RB	RB	_	29	advmod	_	_
28	Bcl-2	bcl-2	NN	NN	_	29	nmod:npmod	_	_
29	deficient	deficient	JJ	JJ	_	12	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	cf.	cf.	VBP	VBP	_	5	parataxis	_	_
32	Sentman	Sentman	NNP	NNP	_	31	dobj	_	_
33	et	et	FW	FW	_	32	compound	_	_
34	al.	al.	FW	FW	_	32	compound	_	_
35	,	,	,	,	_	32	punct	_	_
36	1991	1991	CD	CD	_	32	nummod	_	_
37	;	;	:	:	_	32	punct	_	_
38	Strasser	Strasser	NNP	NNP	_	32	dep	_	_
39	et	et	FW	FW	_	38	compound	_	_
40	al.	al.	FW	FW	_	38	compound	_	_
41	,	,	,	,	_	38	punct	_	_
42	1991	1991	CD	CD	_	38	nummod	_	_
43	)	)	-RRB-	-RRB-	_	31	punct	_	_
44	.	.	.	.	_	5	punct	_	_

1	Even	even	RB	RB	_	2	advmod	_	_
2	so	so	RB	RB	_	6	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	medullary	medullary	JJ	JJ	_	5	amod	_	_
5	thymocytes	thymocyte	NNS	NNS	_	6	nsubj	_	_
6	remain	remain	VBP	VBP	_	0	root	_	_
7	at	at	IN	IN	_	9	advmod	_	_
8	least	least	JJS	JJS	_	7	mwe	_	_
9	partially	partially	RB	RB	_	10	advmod	_	_
10	susceptible	susceptible	JJ	JJ	_	6	xcomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	negative	negative	JJ	JJ	_	13	amod	_	_
13	selection	selection	NN	NN	_	10	nmod	_	_
14	even	even	RB	RB	_	17	advmod	_	_
15	as	as	IN	IN	_	17	mark	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	continue	continue	VBP	VBP	_	6	advcl	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	mature	mature	VB	VB	_	17	xcomp	_	_
20	.	.	.	.	_	6	punct	_	_

1	SRC-related	src-related	JJ	JJ	_	2	amod	_	_
2	proto-oncogenes	proto-oncogene	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	conj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	primary	primary	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	:	:	:	:	_	2	punct	_	_
12	modulation	modulation	NN	NN	_	2	dep	_	_
13	by	by	IN	IN	_	15	case	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	FK506	fk506	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	genes	gene	NNS	NNS	_	6	nmod	_	_
9	encoding	encode	VBG	VBG	_	8	acl	_	_
10	for	for	IN	IN	_	11	case	_	_
11	lymphokines	lymphokine	NNS	NNS	_	9	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-2	il-2	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	controlled	control	VBN	VBN	_	0	root	_	_
9	transcriptionally	transcriptionally	RB	RB	_	8	advmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	specific	specific	JJ	JJ	_	17	amod	_	_
16	trans-activating	trans-activating	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	bind	bind	VBP	VBP	_	17	acl:relcl	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	enhancer	enhancer	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CsA	csa	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	FK506	fk506	NN	NN	_	2	conj	_	_
8	inhibit	inhibit	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-2	il-2	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	at	at	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	level	level	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	member	member	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	src	src	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	the	the	DT	DT	_	13	det	_	_
10	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	13	amod	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	2	appos	_	_
14	,	,	,	,	_	13	punct	_	_
15	p56lck	p56lck	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	has	have	VBZ	VBZ	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	implicated	implicate	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	19	punct	_	_

1	CsA	csa	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	3	ccomp	_	_
7	lck	lck	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	nor	nor	CC	CC	_	9	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	9	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	lck	lck	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	product	product	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	CsA	csa	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	FK506	fk506	NN	NN	_	3	conj	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	appearance	appearance	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	factors	factor	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	bind	bind	VBP	VBP	_	14	acl:relcl	_	_
17	to	to	TO	TO	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	NF-AT	nf-at	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	AP-1	ap-1	NN	NN	_	19	conj	_	_
22	sites	site	NNS	NNS	_	16	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IL-2	il-2	NN	NN	_	26	compound	_	_
26	enhancer	enhancer	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	induction	induction	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-AT	nf-at	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	AP-1	ap-1	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	21	advcl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	same	same	JJ	JJ	_	13	amod	_	_
13	stimuli	stimulus	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	stimulate	stimulate	VBP	VBP	_	13	acl:relcl	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	21	punct	_	_
19	these	these	DT	DT	_	20	det	_	_
20	results	result	NNS	NNS	_	21	nsubj	_	_
21	indicate	indicate	VBP	VBP	_	0	root	_	_
22	that	that	IN	IN	_	31	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	immunosuppressant	immunosuppressant	JJ	JJ	_	25	amod	_	_
25	action	action	NN	NN	_	31	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	CsA	csa	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	FK506	fk506	NN	NN	_	27	conj	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	exerted	exert	VBN	VBN	_	21	ccomp	_	_
32	at	at	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	level	level	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	these	these	DT	DT	_	38	det	_	_
37	trans-activating	trans-activating	JJ	JJ	_	38	amod	_	_
38	factors	factor	NNS	NNS	_	34	nmod	_	_
39	.	.	.	.	_	21	punct	_	_

1	TAR-independent	tar-independent	JJ	JJ	_	2	amod	_	_
2	transactivation	transactivation	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	Tat	tat	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	derived	derive	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	CNS	cns	NN	NN	_	7	nmod	_	_
11	:	:	:	:	_	2	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	novel	novel	JJ	JJ	_	14	amod	_	_
14	mechanism	mechanism	NN	NN	_	2	dep	_	_
15	of	of	IN	IN	_	18	case	_	_
16	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	regulation	regulation	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tat	tat	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	3	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HIV-1	hiv-1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	essential	essential	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	17	case	_	_
16	productive	productive	JJ	JJ	_	17	amod	_	_
17	infection	infection	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	is	be	VBZ	VBZ	_	22	cop	_	_
20	a	a	DT	DT	_	22	det	_	_
21	potential	potential	JJ	JJ	_	22	amod	_	_
22	target	target	NN	NN	_	14	conj	_	_
23	for	for	IN	IN	_	25	case	_	_
24	antiviral	antiviral	JJ	JJ	_	25	amod	_	_
25	therapy	therapy	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	Tat	tat	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potent	potent	JJ	JJ	_	5	amod	_	_
5	activator	activator	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	9	case	_	_
7	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	serves	serve	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	greatly	greatly	RB	RB	_	14	advmod	_	_
14	increase	increase	VB	VB	_	11	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	rate	rate	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	transcription	transcription	NN	NN	_	16	nmod	_	_
19	directed	direct	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	viral	viral	JJ	JJ	_	23	amod	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	29	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	seems	seem	VBZ	VBZ	_	2	acl:relcl	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	5	xcomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	progression	progression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	acquired	acquire	VBN	VBN	_	18	amod	_	_
16	immune	immune	JJ	JJ	_	18	amod	_	_
17	deficiency	deficiency	NN	NN	_	18	compound	_	_
18	syndrome	syndrome	NN	NN	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	AIDS	aids	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	2	punct	_	_
23	may	may	MD	MD	_	29	aux	_	_
24	be	be	VB	VB	_	29	cop	_	_
25	due	due	JJ	JJ	_	29	case	_	_
26	to	to	TO	TO	_	25	mwe	_	_
27	increased	increase	VBN	VBN	_	29	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	initiation	initiation	NN	NN	_	0	root	_	_
30	,	,	,	,	_	29	punct	_	_
31	increased	increase	VBN	VBN	_	33	amod	_	_
32	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
33	elongation	elongation	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	or	or	CC	CC	_	29	cc	_	_
36	a	a	DT	DT	_	37	det	_	_
37	combination	combination	NN	NN	_	29	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	these	these	DT	DT	_	40	det	_	_
40	processes	process	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	29	punct	_	_

1	Much	much	JJ	JJ	_	2	amod	_	_
2	attention	attention	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	focused	focus	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Tat	tat	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	RNA	rna	NN	NN	_	15	compound	_	_
15	target	target	NN	NN	_	8	nmod	_	_
16	termed	term	VBN	VBN	_	15	acl	_	_
17	TAR	tar	NN	NN	_	16	xcomp	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	transactivation	transactivation	NN	NN	_	20	compound	_	_
20	responsive	responsive	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	present	present	JJ	JJ	_	15	acl:relcl	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	leader	leader	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	all	all	DT	DT	_	32	det	_	_
31	HIV-1	hiv-1	NN	NN	_	32	compound	_	_
32	mRNAs	mrna	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	believed	believe	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	9	mark	_	_
6	be	be	VB	VB	_	9	cop	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	4	xcomp	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mechanism	mechanism	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	transactivation	transactivation	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	in	in	IN	IN	_	10	case	_	_
8	certain	certain	JJ	JJ	_	10	amod	_	_
9	CNS-derived	cns-derived	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	13	nmod	_	_
11	Tat	tat	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	capable	capable	JJ	JJ	_	5	ccomp	_	_
14	of	of	IN	IN	_	15	mark	_	_
15	activating	activate	VBG	VBG	_	13	advcl	_	_
16	HIV-1	hiv-1	NN	NN	_	15	dobj	_	_
17	through	through	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	TAR-independent	tar-independent	JJ	JJ	_	20	amod	_	_
20	pathway	pathway	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	Tat-responsive	tat-responsive	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	upstream	upstream	RB	RB	_	5	xcomp	_	_
7	within	within	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	that	that	WDT	WDT	_	16	nsubj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	glial-derived	glial-derived	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	16	nmod	_	_
16	allows	allow	VBZ	VBZ	_	10	acl:relcl	_	_
17	transactivation	transactivation	NN	NN	_	16	dobj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	dep	_	_
20	absence	absence	NN	NN	_	22	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	TAR	tar	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	mapping	mapping	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	hybrid	hybrid	NN	NN	_	6	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	2	conj	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	the	the	DT	DT	_	13	det	_	_
10	newly	newly	RB	RB	_	11	advmod	_	_
11	identified	identify	VBN	VBN	_	13	amod	_	_
12	Tat-responsive	tat-responsive	JJ	JJ	_	13	amod	_	_
13	element	element	NN	NN	_	14	nsubj	_	_
14	corresponds	correspond	VBZ	VBZ	_	7	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	sequence	sequence	NN	NN	_	14	nmod	_	_
18	within	within	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	viral	viral	JJ	JJ	_	23	amod	_	_
21	long	long	JJ	JJ	_	23	amod	_	_
22	terminal	terminal	JJ	JJ	_	23	amod	_	_
23	repeat	repeat	NN	NN	_	17	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	LTR	ltr	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	previously	previously	RB	RB	_	28	advmod	_	_
28	identified	identify	VBN	VBN	_	17	acl	_	_
29	as	as	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	HIV-1	hiv-1	NN	NN	_	32	compound	_	_
32	enhancer	enhancer	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	or	or	CC	CC	_	32	cc	_	_
35	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	domain	domain	NN	NN	_	32	conj	_	_
38	.	.	.	.	_	7	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	band-shift	band-shift	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	reveals	reveal	VBZ	VBZ	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	glial	glial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	differs	differ	VBZ	VBZ	_	8	acl:relcl	_	_
14	from	from	IN	IN	_	15	case	_	_
15	that	that	DT	DT	_	13	nmod	_	_
16	present	present	JJ	JJ	_	15	amod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	T	t	NN	NN	_	20	compound	_	_
19	lymphoid	lymphoid	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Further	further	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observe	observe	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	TAR-deleted	tar-deleted	JJ	JJ	_	7	amod	_	_
7	mutants	mutant	NNS	NNS	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	HIV-1	hiv-1	NN	NN	_	7	nmod	_	_
10	demonstrate	demonstrate	VBP	VBP	_	4	ccomp	_	_
11	normal	normal	JJ	JJ	_	14	amod	_	_
12	late	late	JJ	JJ	_	14	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	glial	glial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	evidenced	evidence	VBN	VBN	_	10	advcl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	syncytia	syncytia	NN	NN	_	19	nmod	_	_
22	formation	formation	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	production	production	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	viral	viral	JJ	JJ	_	28	amod	_	_
27	p24	p24	NN	NN	_	28	compound	_	_
28	antigen	antigen	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Bcl-2	bcl-2	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	repressor	repressor	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	death	death	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	conj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	control	control	VBP	VBP	_	2	acl:relcl	_	_
7	programmed	program	VBN	VBN	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	death	death	NN	NN	_	6	dobj	_	_
10	are	be	VBP	VBP	_	13	cop	_	_
11	currently	currently	RB	RB	_	13	advmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	subject	subject	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	16	case	_	_
15	intense	intense	JJ	JJ	_	16	amod	_	_
16	study	study	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	bcl-2	bcl-2	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	repressor	repressor	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	9	case	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	death	death	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	perhaps	perhaps	RB	RB	_	14	advmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	best	best	JJS	JJS	_	0	root	_	_
15	understood	understand	VBN	VBN	_	14	amod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	programmed	program	VBN	VBN	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	death	death	NN	NN	_	21	nmod:npmod	_	_
21	associated	associated	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	14	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Stanley	Stanley	NNP	NNP	_	4	compound	_	_
4	Korsmeyer	Korsmeyer	NNP	NNP	_	5	nsubj	_	_
5	provides	provide	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	brief	brief	JJ	JJ	_	8	amod	_	_
8	overview	overview	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	bcl-2	bcl-2	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	concentrating	concentrate	VBG	VBG	_	5	advcl	_	_
13	on	on	IN	IN	_	15	case	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	roles	role	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	B-	b-	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	T-cell	t-cell	NN	NN	_	17	conj	_	_
20	development	development	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	in	in	IN	IN	_	23	case	_	_
23	oncogenesis	oncogenesis	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Mitogen	mitogen	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	T-cells	t-cell	NNS	NNS	_	2	nmod	_	_
5	increases	increase	VBZ	VBZ	_	0	root	_	_
6	c-Fos	c-fos	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-Jun	c-jun	NN	NN	_	6	conj	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	5	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	AP-1	ap-1	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	conj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	10	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analysed	analyse	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	mitogenic	mitogenic	JJ	JJ	_	8	amod	_	_
8	lectins	lectin	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	14	case	_	_
10	c-Fos	c-fos	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	c-Jun	c-jun	NN	NN	_	10	conj	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	5	nmod	_	_
15	as	as	RB	RB	_	14	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	on	on	IN	IN	_	24	case	_	_
19	activator	activator	NN	NN	_	20	compound	_	_
20	protein-1	protein-1	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	AP-1	ap-1	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	binding	binding	NN	NN	_	14	conj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	enhancer	enhancer	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	Jurkat	jurkat	NN	NN	_	30	compound	_	_
30	T-cells	t-cell	NNS	NNS	_	5	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	c-Fos	c-fos	NN	NN	_	6	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	c-Jun	c-jun	NN	NN	_	2	conj	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	after	after	IN	IN	_	14	case	_	_
10	Con	con	NN	NN	_	11	compound	_	_
11	A	a	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	PHA	pha	NN	NN	_	11	conj	_	_
14	stimulation	stimulation	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	4	nsubj	_	_
4	increases	increase	VBZ	VBZ	_	33	advcl	_	_
5	both	both	CC	CC	_	10	cc:preconj	_	_
6	intracellular	intracellular	JJ	JJ	_	10	dep	_	_
7	Ca2+	ca2+	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cAMP	camp	NN	NN	_	7	conj	_	_
10	levels	level	NNS	NNS	_	4	dobj	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	activates	activate	VBZ	VBZ	_	4	conj	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	12	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PKC	pkc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	33	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	possible	possible	JJ	JJ	_	22	amod	_	_
22	involvement	involvement	NN	NN	_	33	nsubjpass	_	_
23	of	of	IN	IN	_	26	case	_	_
24	these	these	DT	DT	_	26	det	_	_
25	intracellular	intracellular	JJ	JJ	_	26	amod	_	_
26	messengers	messenger	NNS	NNS	_	22	nmod	_	_
27	in	in	IN	IN	_	31	case	_	_
28	c-Fos	c-fos	NN	NN	_	31	compound	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	c-Jun	c-jun	NN	NN	_	28	conj	_	_
31	induction	induction	NN	NN	_	22	nmod	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	tested	test	VBN	VBN	_	0	root	_	_
34	.	.	.	.	_	33	punct	_	_

1	PMA	pma	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	5	nsubj	_	_
4	directly	directly	RB	RB	_	5	advmod	_	_
5	activates	activate	VBZ	VBZ	_	1	acl:relcl	_	_
6	PKC	pkc	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	1	punct	_	_
8	mimicked	mimic	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	lectins	lectin	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	15	case	_	_
15	c-Fos	c-fos	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	c-Jun	c-jun	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	8	punct	_	_
19	but	but	CC	CC	_	8	cc	_	_
20	elevation	elevation	NN	NN	_	28	nsubj	_	_
21	of	of	IN	IN	_	27	case	_	_
22	either	either	CC	CC	_	27	cc:preconj	_	_
23	intracellular	intracellular	JJ	JJ	_	27	dep	_	_
24	Ca2+	ca2+	NN	NN	_	27	compound	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	cAMP	camp	NN	NN	_	24	conj	_	_
27	levels	level	NNS	NNS	_	20	nmod	_	_
28	had	have	VBD	VBD	_	8	conj	_	_
29	little	little	JJ	JJ	_	32	amod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	no	no	DT	DT	_	29	conj	_	_
32	effect	effect	NN	NN	_	28	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mitogen-induced	mitogen-induced	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	c-Fos	c-fos	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-Jun	c-jun	NN	NN	_	5	conj	_	_
8	immunoreactivity	immunoreactivity	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	H-7	h-7	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	inhibitor	inhibitor	NN	NN	_	12	appos	_	_
17	with	with	IN	IN	_	20	case	_	_
18	relatively	relatively	RB	RB	_	19	advmod	_	_
19	high	high	JJ	JJ	_	20	amod	_	_
20	specificity	specificity	NN	NN	_	16	nmod	_	_
21	for	for	IN	IN	_	22	case	_	_
22	PKC	pkc	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	and	and	CC	CC	_	10	cc	_	_
25	less	less	RBR	RBR	_	26	advmod	_	_
26	efficiently	efficiently	RB	RB	_	10	conj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	H-8	h-8	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	a	a	DT	DT	_	34	det	_	_
31	structurally	structurally	RB	RB	_	32	advmod	_	_
32	related	related	JJ	JJ	_	34	amod	_	_
33	kinase	kinase	NN	NN	_	34	compound	_	_
34	inhibitor	inhibitor	NN	NN	_	28	dep	_	_
35	less	less	RBR	RBR	_	36	advmod	_	_
36	active	active	JJ	JJ	_	34	amod	_	_
37	on	on	IN	IN	_	38	case	_	_
38	PKC	pkc	NN	NN	_	36	nmod	_	_
39	,	,	,	,	_	36	punct	_	_
40	but	but	CC	CC	_	36	cc	_	_
41	more	more	RBR	RBR	_	42	advmod	_	_
42	active	active	JJ	JJ	_	36	conj	_	_
43	on	on	IN	IN	_	46	case	_	_
44	cyclic	cyclic	JJ	JJ	_	45	amod	_	_
45	nucleotide-dependent	nucleotide-dependent	JJ	JJ	_	46	amod	_	_
46	kinases	kinase	NNS	NNS	_	42	nmod	_	_
47	.	.	.	.	_	10	punct	_	_

1	Con	con	NN	NN	_	3	compound	_	_
2	A	a	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	increase	increase	VB	VB	_	5	xcomp	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AP-1	ap-1	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	AP-1	ap-1	NN	NN	_	16	compound	_	_
15	consensus	consensus	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	9	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	TRE	tre	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	AP-1	ap-1	NN	NN	_	23	compound	_	_
22	enhancer	enhancer	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	9	conj	_	_
24	,	,	,	,	_	9	punct	_	_
25	in	in	IN	IN	_	27	case	_	_
26	Jurkat	jurkat	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	9	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	PMA	pma	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	increase	increase	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	10	det	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	whereas	whereas	IN	IN	_	4	dep	_	_
13	elevation	elevation	NN	NN	_	18	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Ca2+	ca2+	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	cAMP	camp	NN	NN	_	15	conj	_	_
18	had	have	VBD	VBD	_	4	parataxis	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	minor	minor	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	18	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	stimulation	stimulation	NN	NN	_	9	nsubj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	mitogenic	mitogenic	JJ	JJ	_	7	amod	_	_
7	lectins	lectin	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	sufficient	sufficient	JJ	JJ	_	2	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	increase	increase	VB	VB	_	9	xcomp	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	c-Fos	c-fos	NN	NN	_	17	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-Jun	c-jun	NN	NN	_	13	conj	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	11	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	AP-1	ap-1	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	17	conj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	AP-1	ap-1	NN	NN	_	24	compound	_	_
23	enhancer	enhancer	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	17	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	Jurkat	jurkat	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	17	nmod	_	_
28	and	and	CC	CC	_	9	cc	_	_
29	that	that	IN	IN	_	31	mark	_	_
30	they	they	PRP	PRP	_	31	nsubj	_	_
31	act	act	VBP	VBP	_	9	conj	_	_
32	via	via	IN	IN	_	33	case	_	_
33	mechanisms	mechanism	NNS	NNS	_	31	nmod	_	_
34	that	that	WDT	WDT	_	36	nsubj	_	_
35	could	could	MD	MD	_	36	aux	_	_
36	involve	involve	VB	VB	_	33	acl:relcl	_	_
37	the	the	DT	DT	_	38	det	_	_
38	activation	activation	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	PKC	pkc	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	two	two	CD	CD	_	8	nummod	_	_
6	zinc	zinc	NN	NN	_	8	compound	_	_
7	finger	finger	NN	NN	_	8	compound	_	_
8	domains	domain	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	v-erb	v-erb	NN	NN	_	13	compound	_	_
12	A	a	NN	NN	_	13	compound	_	_
13	oncoprotein	oncoprotein	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	v-erb	v-erb	NN	NN	_	4	compound	_	_
3	A	a	NN	NN	_	4	compound	_	_
4	oncogene	oncogene	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	avian	avian	JJ	JJ	_	8	amod	_	_
7	erythroblastosis	erythroblastosis	NN	NN	_	8	compound	_	_
8	virus	virus	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	15	cop	_	_
10	a	a	DT	DT	_	15	det	_	_
11	mutated	mutate	VBN	VBN	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	virally	virally	RB	RB	_	14	advmod	_	_
14	transduced	transduce	VBN	VBN	_	11	conj	_	_
15	copy	copy	NN	NN	_	0	root	_	_
16	of	of	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	host	host	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	encoding	encode	VBG	VBG	_	20	acl	_	_
22	a	a	DT	DT	_	25	det	_	_
23	thyroid	thyroid	NN	NN	_	25	compound	_	_
24	hormone	hormone	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	9	nsubj	_	_
3	expressed	express	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	v-erb	v-erb	NN	NN	_	8	compound	_	_
7	A	a	NN	NN	_	8	compound	_	_
8	oncogene	oncogene	NN	NN	_	3	nmod	_	_
9	binds	bind	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	DNA	dna	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	acts	act	VBZ	VBZ	_	9	conj	_	_
14	as	as	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	dominant	dominant	JJ	JJ	_	18	amod	_	_
17	negative	negative	JJ	JJ	_	18	amod	_	_
18	inhibitor	inhibitor	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	both	both	CC	CC	_	24	cc:preconj	_	_
21	the	the	DT	DT	_	24	det	_	_
22	thyroid	thyroid	NN	NN	_	24	compound	_	_
23	hormone	hormone	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	18	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	31	det	_	_
27	closely	closely	RB	RB	_	28	advmod	_	_
28	related	related	JJ	JJ	_	31	amod	_	_
29	retinoic	retinoic	JJ	JJ	_	31	amod	_	_
30	acid	acid	NN	NN	_	31	compound	_	_
31	receptor	receptor	NN	NN	_	24	conj	_	_
32	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	v-erb	v-erb	NN	NN	_	4	compound	_	_
3	A	a	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubj	_	_
5	has	have	VBZ	VBZ	_	6	aux	_	_
6	sustained	sustain	VBN	VBN	_	0	root	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	amino	amino	NN	NN	_	10	compound	_	_
9	acid	acid	NN	NN	_	10	compound	_	_
10	alterations	alteration	NNS	NNS	_	6	dobj	_	_
11	within	within	IN	IN	_	14	case	_	_
12	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	6	nmod	_	_
15	relative	relative	JJ	JJ	_	17	case	_	_
16	to	to	TO	TO	_	17	case	_	_
17	that	that	DT	DT	_	6	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	c-erb	c-erb	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	one	one	CD	CD	_	31	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	22	nmod	_	_
25	,	,	,	,	_	22	punct	_	_
26	at	at	IN	IN	_	27	case	_	_
27	serine	serine	NN	NN	_	22	nmod	_	_
28	61	61	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	31	punct	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	known	know	VBN	VBN	_	20	acl:relcl	_	_
32	to	to	TO	TO	_	34	mark	_	_
33	be	be	VB	VB	_	34	cop	_	_
34	important	important	JJ	JJ	_	31	xcomp	_	_
35	for	for	IN	IN	_	38	case	_	_
36	v-erb	v-erb	NN	NN	_	38	compound	_	_
37	A	a	NN	NN	_	38	compound	_	_
38	function	function	NN	NN	_	34	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	neoplastic	neoplastic	JJ	JJ	_	42	amod	_	_
42	cell	cell	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	second	second	JJ	JJ	_	7	amod	_	_
7	alteration	alteration	NN	NN	_	14	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	at	at	IN	IN	_	10	case	_	_
10	threonine	threonine	NN	NN	_	7	nmod	_	_
11	78	78	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	7	punct	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	plays	play	VBZ	VBZ	_	2	ccomp	_	_
15	an	a	DT	DT	_	22	det	_	_
16	important	important	JJ	JJ	_	22	amod	_	_
17	,	,	,	,	_	16	punct	_	_
18	although	although	IN	IN	_	16	dep	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	indirect	indirect	JJ	JJ	_	16	dep	_	_
21	,	,	,	,	_	16	punct	_	_
22	role	role	NN	NN	_	14	dobj	_	_
23	:	:	:	:	_	2	punct	_	_
24	alteration	alteration	NN	NN	_	40	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	sequence	sequence	NN	NN	_	24	nmod	_	_
28	at	at	IN	IN	_	29	case	_	_
29	threonine	threonine	NN	NN	_	24	nmod	_	_
30	78	78	CD	CD	_	29	nummod	_	_
31	such	such	JJ	JJ	_	34	dep	_	_
32	that	that	IN	IN	_	34	mark	_	_
33	it	it	PRP	PRP	_	34	nsubj	_	_
34	resembles	resemble	VBZ	VBZ	_	24	dep	_	_
35	that	that	DT	DT	_	34	xcomp	_	_
36	of	of	IN	IN	_	38	case	_	_
37	c-erb	c-erb	NN	NN	_	38	compound	_	_
38	A	a	NN	NN	_	35	nmod	_	_
39	can	can	MD	MD	_	40	aux	_	_
40	act	act	VB	VB	_	2	parataxis	_	_
41	as	as	IN	IN	_	44	case	_	_
42	an	a	DT	DT	_	44	det	_	_
43	intragenic	intragenic	JJ	JJ	_	44	amod	_	_
44	suppressor	suppressor	NN	NN	_	40	nmod	_	_
45	and	and	CC	CC	_	40	cc	_	_
46	can	can	MD	MD	_	48	aux	_	_
47	partially	partially	RB	RB	_	48	advmod	_	_
48	restore	restore	VB	VB	_	40	conj	_	_
49	function	function	NN	NN	_	48	dobj	_	_
50	to	to	TO	TO	_	54	case	_	_
51	a	a	DT	DT	_	54	det	_	_
52	v-erb	v-erb	NN	NN	_	54	compound	_	_
53	A	a	NN	NN	_	54	compound	_	_
54	protein	protein	NN	NN	_	48	nmod	_	_
55	rendered	render	VBN	VBN	_	54	acl	_	_
56	defective	defective	JJ	JJ	_	55	xcomp	_	_
57	due	due	JJ	JJ	_	60	case	_	_
58	to	to	TO	TO	_	57	mwe	_	_
59	a	a	DT	DT	_	60	det	_	_
60	mutation	mutation	NN	NN	_	55	nmod	_	_
61	at	at	IN	IN	_	62	case	_	_
62	position	position	NN	NN	_	60	nmod	_	_
63	61	61	CD	CD	_	62	nummod	_	_
64	.	.	.	.	_	40	punct	_	_

1	Threonine	threonine	NN	NN	_	3	nsubj	_	_
2	78	78	CD	CD	_	1	nummod	_	_
3	lies	lie	VBZ	VBZ	_	0	root	_	_
4	within	within	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	D-box	d-box	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	v-erb	v-erb	NN	NN	_	11	compound	_	_
10	A	a	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	region	region	NN	NN	_	6	dep	_	_
15	thought	think	VBN	VBN	_	14	acl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	mediate	mediate	VB	VB	_	15	xcomp	_	_
18	receptor-receptor	receptor-receptor	JJ	JJ	_	19	amod	_	_
19	dimerizations	dimerization	NNS	NNS	_	17	dobj	_	_
20	,	,	,	,	_	3	punct	_	_
21	and	and	CC	CC	_	3	cc	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	not	not	RB	RB	_	26	neg	_	_
24	in	in	IN	IN	_	26	case	_	_
25	physical	physical	JJ	JJ	_	26	amod	_	_
26	proximity	proximity	NN	NN	_	3	conj	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	serine	serine	NN	NN	_	26	nmod	_	_
30	at	at	IN	IN	_	31	case	_	_
31	position	position	NN	NN	_	29	nmod	_	_
32	61	61	CD	CD	_	31	nummod	_	_
33	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	an	a	DT	DT	_	7	det	_	_
6	indirect	indirect	JJ	JJ	_	7	amod	_	_
7	interaction	interaction	NN	NN	_	8	nsubj	_	_
8	occurs	occur	VBZ	VBZ	_	3	ccomp	_	_
9	between	between	IN	IN	_	12	case	_	_
10	these	these	DT	DT	_	12	det	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	sites	site	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	this	this	DT	DT	_	16	det	_	_
16	interaction	interaction	NN	NN	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	crucial	crucial	JJ	JJ	_	8	conj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	v-erb	v-erb	NN	NN	_	22	compound	_	_
21	A	a	NN	NN	_	22	compound	_	_
22	function	function	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Pax-5	pax-5	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	BSAP	bsap	NN	NN	_	2	dobj	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	2	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	developing	develop	VBG	VBG	_	16	amod	_	_
16	CNS	cn	NNS	NNS	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	adult	adult	JJ	JJ	_	20	amod	_	_
20	testis	testis	NN	NN	_	12	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	BSAP	bsap	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	previously	previously	RB	RB	_	4	advmod	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	9	acl:relcl	_	_
13	at	at	IN	IN	_	20	case	_	_
14	early	early	JJ	JJ	_	20	amod	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	late	late	JJ	JJ	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	stages	stage	NNS	NNS	_	12	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	B-cell	b-cell	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Biochemical	biochemical	JJ	JJ	_	2	amod	_	_
2	purification	purification	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	cloning	cloning	NN	NN	_	2	conj	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	now	now	RB	RB	_	8	advmod	_	_
8	revealed	reveal	VBN	VBN	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	BSAP	bsap	NN	NN	_	11	nsubj	_	_
11	belongs	belong	VBZ	VBZ	_	8	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	family	family	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	paired	paired	JJ	JJ	_	18	amod	_	_
17	domain	domain	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	BSAP	bsap	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	encoded	encode	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Pax-5	pax-5	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	has	have	VBZ	VBZ	_	12	aux	_	_
10	been	be	VBN	VBN	_	12	auxpass	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	conserved	conserve	VBN	VBN	_	3	conj	_	_
13	between	between	IN	IN	_	14	case	_	_
14	human	human	JJ	JJ	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	mouse	mouse	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	intact	intact	JJ	JJ	_	4	amod	_	_
3	paired	paired	JJ	JJ	_	4	amod	_	_
4	domain	domain	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	necessary	necessary	JJ	JJ	_	6	xcomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	BSAP	bsap	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Binding	bind	VBG	VBG	_	2	amod	_	_
2	studies	study	NNS	NNS	_	8	nsubj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	several	several	JJ	JJ	_	7	amod	_	_
5	BSAP	bsap	NN	NN	_	7	compound	_	_
6	recognition	recognition	NN	NN	_	7	compound	_	_
7	sequences	sequence	NNS	NNS	_	2	nmod	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	sequence	sequence	NN	NN	_	12	compound	_	_
12	specificity	specificity	NN	NN	_	15	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	BSAP	bsap	NN	NN	_	12	nmod	_	_
15	differs	differ	VBZ	VBZ	_	8	ccomp	_	_
16	from	from	IN	IN	_	17	case	_	_
17	that	that	DT	DT	_	15	nmod	_	_
18	of	of	IN	IN	_	25	case	_	_
19	the	the	DT	DT	_	25	det	_	_
20	distantly	distantly	RB	RB	_	21	advmod	_	_
21	related	related	JJ	JJ	_	25	amod	_	_
22	paired	paired	JJ	JJ	_	25	amod	_	_
23	domain	domain	NN	NN	_	25	compound	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	Pax-1	pax-1	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	During	during	IN	IN	_	2	case	_	_
2	embryogenesis	embryogenesis	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	BSAP	bsap	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	transiently	transiently	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mesencephalon	mesencephalon	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	spinal	spinal	JJ	JJ	_	15	amod	_	_
15	cord	cord	NN	NN	_	12	conj	_	_
16	with	with	IN	IN	_	22	case	_	_
17	a	a	DT	DT	_	22	det	_	_
18	spatial	spatial	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	temporal	temporal	JJ	JJ	_	18	conj	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	pattern	pattern	NN	NN	_	9	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	distinct	distinct	JJ	JJ	_	22	acl:relcl	_	_
26	from	from	IN	IN	_	27	case	_	_
27	that	that	DT	DT	_	25	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	other	other	JJ	JJ	_	31	amod	_	_
30	Pax	pax	NN	NN	_	31	compound	_	_
31	genes	gene	NNS	NNS	_	27	nmod	_	_
32	in	in	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	developing	develop	VBG	VBG	_	37	amod	_	_
35	central	central	JJ	JJ	_	37	amod	_	_
36	nervous	nervous	JJ	JJ	_	37	amod	_	_
37	system	system	NN	NN	_	31	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	CNS	cns	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	9	punct	_	_

1	Later	later	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	BSAP	bsap	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	shifts	shift	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	fetal	fetal	JJ	JJ	_	13	amod	_	_
13	liver	liver	NN	NN	_	9	nmod	_	_
14	where	where	WRB	WRB	_	16	advmod	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	correlates	correlate	VBZ	VBZ	_	13	acl:relcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	onset	onset	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	lymphopoiesis	lymphopoiesis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	BSAP	bsap	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	persists	persist	VBZ	VBZ	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	seen	see	VBN	VBN	_	3	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	testis	testis	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	adult	adult	JJ	JJ	_	17	amod	_	_
17	mouse	mouse	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	evidence	evidence	NN	NN	_	1	nmod	_	_
5	indicates	indicate	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	BSAP	bsap	NN	NN	_	14	nsubj	_	_
11	may	may	MD	MD	_	14	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	only	only	RB	RB	_	14	cc:preconj	_	_
14	play	play	VB	VB	_	5	ccomp	_	_
15	an	a	DT	DT	_	17	det	_	_
16	important	important	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B-cell	b-cell	NN	NN	_	20	compound	_	_
20	differentiation	differentiation	NN	NN	_	14	nmod	_	_
21	but	but	CC	CC	_	14	cc	_	_
22	also	also	RB	RB	_	14	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	neural	neural	JJ	JJ	_	25	amod	_	_
25	development	development	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	spermatogenesis	spermatogenesis	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	5	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	inducer	inducer	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	AP-1	ap-1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	tumor	tumor	NN	NN	_	16	compound	_	_
15	necrosis	necrosis	NN	NN	_	16	compound	_	_
16	factor-alpha	factor-alpha	NN	NN	_	8	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Treatment	treatment	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	optimal	optimal	JJ	JJ	_	9	amod	_	_
9	concentration	concentration	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	okadaic	okadaic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	an	a	DT	DT	_	15	det	_	_
15	inhibitor	inhibitor	NN	NN	_	12	appos	_	_
16	of	of	IN	IN	_	17	case	_	_
17	phosphatases	phosphatase	NNS	NNS	_	15	nmod	_	_
18	1	1	CD	CD	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	2A	2a	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	resulted	result	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	induction	induction	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	AP-1	ap-1	NN	NN	_	29	appos	_	_
32	and	and	CC	CC	_	25	cc	_	_
33	a	a	DT	DT	_	35	det	_	_
34	marked	marked	JJ	JJ	_	35	amod	_	_
35	increase	increase	NN	NN	_	25	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	39	compound	_	_
38	B	b	NN	NN	_	39	compound	_	_
39	levels	level	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	no	no	DT	DT	_	5	neg	_	_
5	effect	effect	NN	NN	_	20	nsubjpass	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	levels	level	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	octamer	octamer	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	Oct-1	oct-1	NN	NN	_	13	appos	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	Oct-2	oct-2	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	both	both	CC	CC	_	3	cc:preconj	_	_
3	AP-1	ap-1	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	conj	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	reported	report	VBN	VBN	_	26	advcl	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	important	important	JJ	JJ	_	9	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	24	case	_	_
17	the	the	DT	DT	_	24	det	_	_
18	tumor	tumor	NN	NN	_	20	compound	_	_
19	necrosis	necrosis	NN	NN	_	20	compound	_	_
20	factor-alpha	factor-alpha	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	examined	examine	VBD	VBD	_	0	root	_	_
27	the	the	DT	DT	_	28	det	_	_
28	effects	effect	NNS	NNS	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	okadaic	okadaic	JJ	JJ	_	31	amod	_	_
31	acid	acid	NN	NN	_	28	nmod	_	_
32	on	on	IN	IN	_	35	case	_	_
33	TNF-alpha	tnf-alpha	NN	NN	_	35	compound	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	levels	level	NNS	NNS	_	28	nmod	_	_
36	.	.	.	.	_	26	punct	_	_

1	Treatment	treatment	NN	NN	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	okadaic	okadaic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	1	nmod	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	striking	striking	JJ	JJ	_	9	amod	_	_
9	increase	increase	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	9	nmod	_	_
14	within	within	IN	IN	_	16	case	_	_
15	1	1	CD	CD	_	16	nummod	_	_
16	h	h	NN	NN	_	5	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	stimulation	stimulation	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	large	large	JJ	JJ	_	21	amod	_	_
21	amounts	amount	NNS	NNS	_	25	nsubjpass	_	_
22	of	of	IN	IN	_	23	case	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	21	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	released	release	VBN	VBN	_	5	conj	_	_
26	into	into	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	culture	culture	NN	NN	_	29	compound	_	_
29	media	media	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	okadaic	okadaic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	4	nsubj	_	_
4	provides	provide	VBZ	VBZ	_	17	advcl	_	_
5	a	a	DT	DT	_	8	det	_	_
6	potent	potent	JJ	JJ	_	8	amod	_	_
7	inductive	inductive	JJ	JJ	_	8	amod	_	_
8	signal	signal	NN	NN	_	4	dobj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	AP-1	ap-1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	conj	_	_
14	it	it	PRP	PRP	_	17	nsubj	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	induce	induce	VB	VB	_	0	root	_	_
18	either	either	CC	CC	_	21	cc:preconj	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	proliferation	proliferation	NN	NN	_	17	dobj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
24	secretion	secretion	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	Ets-related	ets-related	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	9	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	Elf-1	elf-1	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	binds	bind	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	17	case	_	_
11	human	human	JJ	JJ	_	17	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
13	virus	virus	NN	NN	_	17	compound	_	_
14	type	type	NN	NN	_	17	compound	_	_
15	2	2	CD	CD	_	17	nummod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	elements	element	NNS	NNS	_	9	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	required	require	VBN	VBN	_	17	acl:relcl	_	_
21	for	for	IN	IN	_	24	case	_	_
22	inducible	inducible	JJ	JJ	_	24	amod	_	_
23	trans	trans	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	14	nsubj	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	HIV-2	hiv-2	NN	NN	_	4	conj	_	_
11	are	be	VBP	VBP	_	14	cop	_	_
12	structurally	structurally	RB	RB	_	13	advmod	_	_
13	related	related	JJ	JJ	_	14	amod	_	_
14	retroviruses	retrovirus	NNS	NNS	_	0	root	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	both	both	DT	DT	_	17	dep	_	_
17	cause	cause	VBP	VBP	_	14	acl:relcl	_	_
18	AIDS	aids	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	humans	human	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	both	both	DT	DT	_	3	det	_	_
3	viruses	virus	NNS	NNS	_	4	nsubj	_	_
4	establish	establish	VBP	VBP	_	21	advcl	_	_
5	latency	latency	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	quiescent	quiescent	JJ	JJ	_	10	amod	_	_
8	human-peripheral-blood	human-peripheral-blood	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	,	,	,	,	_	21	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	asymptomatic	asymptomatic	JJ	JJ	_	14	amod	_	_
14	phase	phase	NN	NN	_	21	nsubj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HIV-2	hiv-2	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	14	nmod	_	_
18	may	may	MD	MD	_	21	aux	_	_
19	be	be	VB	VB	_	21	cop	_	_
20	more	more	JJR	JJR	_	21	dep	_	_
21	prolonged	prolonged	JJ	JJ	_	0	root	_	_
22	than	than	IN	IN	_	23	case	_	_
23	that	that	DT	DT	_	21	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	HIV-1	hiv-1	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latent	latent	JJ	JJ	_	3	amod	_	_
3	phases	phase	NNS	NNS	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	HIV-2	hiv-2	NN	NN	_	6	conj	_	_
9	infection	infection	NN	NN	_	3	nmod	_	_
10	have	have	VBP	VBP	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	aux	_	_
15	disrupted	disrupt	VBN	VBN	_	12	xcomp	_	_
16	by	by	IN	IN	_	18	case	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	a	a	DT	DT	_	21	det	_	_
21	process	process	NN	NN	_	15	dobj	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	requires	require	VBZ	VBZ	_	21	acl:relcl	_	_
24	host	host	NN	NN	_	27	compound	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	23	dobj	_	_
28	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	13	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HIV-1	hiv-1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	the	the	DT	DT	_	11	det	_	_
8	transcription	transcription	NN	NN	_	11	compound	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	17	case	_	_
15	inducible	inducible	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
5	in	in	IN	IN	_	9	case	_	_
6	addition	addition	NN	NN	_	9	dep	_	_
7	to	to	TO	TO	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	activate	activate	VB	VB	_	11	xcomp	_	_
14	HIV-2	hiv-2	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	infected	infected	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	a	a	DT	DT	_	12	det	_	_
9	novel	novel	JJ	JJ	_	12	amod	_	_
10	Ets-related	ets-related	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	16	nsubj	_	_
13	,	,	,	,	_	12	punct	_	_
14	Elf-1	elf-1	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	binds	bind	VBZ	VBZ	_	6	ccomp	_	_
17	specifically	specifically	RB	RB	_	16	advmod	_	_
18	to	to	TO	TO	_	21	case	_	_
19	two	two	CD	CD	_	21	nummod	_	_
20	purine-rich	purine-rich	JJ	JJ	_	21	amod	_	_
21	motifs	motif	NNS	NNS	_	16	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	HIV-2	hiv-2	NN	NN	_	25	compound	_	_
25	enhancer	enhancer	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Mutagenesis	mutagenesis	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	these	these	DT	DT	_	8	det	_	_
6	Elf-1	elf-1	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	3	ccomp	_	_
11	for	for	IN	IN	_	12	case	_	_
12	induction	induction	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HIV-2	hiv-2	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	following	follow	VBG	VBG	_	19	case	_	_
17	T-cell-receptor-mediated	t-cell-receptor-mediated	JJ	JJ	_	19	amod	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	Elf-1	elf-1	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	the	the	DT	DT	_	7	det	_	_
6	only	only	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	present	present	JJ	JJ	_	7	amod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	activated	activate	VBN	VBN	_	13	amod	_	_
11	T-cell	t-cell	NN	NN	_	13	compound	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	8	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	binds	bind	VBZ	VBZ	_	13	acl:relcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	sites	site	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	electrophoretic	electrophoretic	JJ	JJ	_	23	amod	_	_
21	mobility	mobility	NN	NN	_	23	compound	_	_
22	shift	shift	NN	NN	_	23	compound	_	_
23	assays	assay	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Elf-1	elf-1	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	appears	appear	VBZ	VBZ	_	8	acl:relcl	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	required	require	VBN	VBN	_	10	xcomp	_	_
14	for	for	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	T-cell-receptor-mediated	t-cell-receptor-mediated	JJ	JJ	_	18	amod	_	_
17	trans	trans	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	HIV-2	hiv-2	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	explain	explain	VB	VB	_	0	root	_	_
5	differences	difference	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	clinical	clinical	JJ	JJ	_	9	amod	_	_
9	spectra	spectrum	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	diseases	disease	NNS	NNS	_	9	nmod	_	_
12	caused	cause	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	HIV-1	hiv-1	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HIV-2	hiv-2	NN	NN	_	14	conj	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	have	have	VB	VB	_	4	conj	_	_
21	implications	implication	NNS	NNS	_	20	dobj	_	_
22	for	for	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	design	design	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	therapeutic	therapeutic	JJ	JJ	_	27	amod	_	_
27	approaches	approach	NNS	NNS	_	24	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	HIV-2	hiv-2	NN	NN	_	30	compound	_	_
30	infection	infection	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Human	human	JJ	JJ	_	7	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
3	virus	virus	NN	NN	_	7	compound	_	_
4	type	type	NN	NN	_	7	compound	_	_
5	1	1	CD	CD	_	7	nummod	_	_
6	Nef	nef	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	8	nsubj	_	_
8	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	10	nsubj	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	establish	establish	VB	VB	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	persistent	persistent	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	latent	latent	JJ	JJ	_	12	conj	_	_
15	infection	infection	NN	NN	_	10	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	CD4+	cd4+	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	W.C.Greene	W.C.Greene	NNP	NNP	_	10	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	N.Engl.J.	N.Engl.J.	NNP	NNP	_	24	compound	_	_
24	Med.324	Med.324	NNP	NNP	_	21	appos	_	_
25	:	:	:	:	_	24	punct	_	_
26	308-317	308-317	CD	CD	_	24	nummod	_	_
27	,	,	,	,	_	21	punct	_	_
28	1991	1991	CD	CD	_	21	amod	_	_
29	;	;	:	:	_	21	punct	_	_
30	S.M.Schnittman	S.M.Schnittman	NNP	NNP	_	21	dep	_	_
31	,	,	,	,	_	30	punct	_	_
32	M.C.Psallidopoulos	M.C.Psallidopoulos	NNP	NNP	_	30	conj	_	_
33	,	,	,	,	_	30	punct	_	_
34	H.C.	H.C.	NNP	NNP	_	35	compound	_	_
35	Lane	Lane	NNP	NNP	_	30	conj	_	_
36	,	,	,	,	_	30	punct	_	_
37	L.Thompson	L.Thompson	NNP	NNP	_	30	conj	_	_
38	,	,	,	,	_	30	punct	_	_
39	M.Baseler	M.Baseler	NNP	NNP	_	30	conj	_	_
40	,	,	,	,	_	30	punct	_	_
41	F.Massari	F.Massari	NNP	NNP	_	30	conj	_	_
42	,	,	,	,	_	30	punct	_	_
43	C.H.Fox	C.H.Fox	NNP	NNP	_	30	conj	_	_
44	,	,	,	,	_	30	punct	_	_
45	N.P.Salzman	N.P.Salzman	NNP	NNP	_	30	conj	_	_
46	,	,	,	,	_	30	punct	_	_
47	and	and	CC	CC	_	30	cc	_	_
48	A.S.Fauci	A.S.Fauci	NNP	NNP	_	30	conj	_	_
49	,	,	,	,	_	30	punct	_	_
50	Science	Science	NNP	NNP	_	30	appos	_	_
51	245	245	CD	CD	_	50	nummod	_	_
52	:	:	:	:	_	50	punct	_	_
53	305-308	305-308	CD	CD	_	50	nummod	_	_
54	,	,	,	,	_	30	punct	_	_
55	1989	1989	CD	CD	_	30	amod	_	_
56	)	)	-RRB-	-RRB-	_	21	punct	_	_
57	.	.	.	.	_	10	punct	_	_

1	Production	production	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HIV-1	hiv-1	NN	NN	_	1	nmod	_	_
4	from	from	IN	IN	_	7	case	_	_
5	latently	latently	RB	RB	_	6	advmod	_	_
6	infected	infected	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	host	host	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	mitogens	mitogen	NNS	NNS	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	T.Folks	T.Folks	NNP	NNP	_	8	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	D.M.Powell	D.M.Powell	NNP	NNP	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	M.M.Lightfoote	M.M.Lightfoote	NNP	NNP	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	S.Benn	S.Benn	NNP	NNP	_	16	conj	_	_
23	,	,	,	,	_	16	punct	_	_
24	M.A.	M.A.	NNP	NNP	_	25	compound	_	_
25	Martin	Martin	NNP	NNP	_	16	conj	_	_
26	,	,	,	,	_	16	punct	_	_
27	and	and	CC	CC	_	16	cc	_	_
28	A.S.Fauci	A.S.Fauci	NNP	NNP	_	16	conj	_	_
29	,	,	,	,	_	16	punct	_	_
30	Science	Science	NNP	NNP	_	16	appos	_	_
31	231	231	CD	CD	_	30	nummod	_	_
32	:	:	:	:	_	30	punct	_	_
33	600-602	600-602	CD	CD	_	30	nummod	_	_
34	,	,	,	,	_	16	punct	_	_
35	1986	1986	CD	CD	_	16	amod	_	_
36	;	;	:	:	_	16	punct	_	_
37	D.Zagury	D.Zagury	NNP	NNP	_	16	dep	_	_
38	,	,	,	,	_	37	punct	_	_
39	J.	J.	NNP	NNP	_	40	compound	_	_
40	Bernard	Bernard	NNP	NNP	_	37	conj	_	_
41	,	,	,	,	_	37	punct	_	_
42	R.Leonard	R.Leonard	NNP	NNP	_	37	conj	_	_
43	,	,	,	,	_	37	punct	_	_
44	R.Cheynier	R.Cheynier	NNP	NNP	_	37	conj	_	_
45	,	,	,	,	_	37	punct	_	_
46	M.Feldman	M.Feldman	NNP	NNP	_	37	conj	_	_
47	,	,	,	,	_	37	punct	_	_
48	P.S.Sarin	P.S.Sarin	NNP	NNP	_	37	conj	_	_
49	,	,	,	,	_	37	punct	_	_
50	and	and	CC	CC	_	37	cc	_	_
51	R.C.	R.C.	NNP	NNP	_	52	compound	_	_
52	Gallo	Gallo	NNP	NNP	_	37	conj	_	_
53	,	,	,	,	_	37	punct	_	_
54	Science	Science	NNP	NNP	_	37	appos	_	_
55	231	231	CD	CD	_	54	nummod	_	_
56	:	:	:	:	_	54	punct	_	_
57	850-853	850-853	CD	CD	_	54	nummod	_	_
58	,	,	,	,	_	37	punct	_	_
59	1986	1986	CD	CD	_	37	amod	_	_
60	)	)	-RRB-	-RRB-	_	16	punct	_	_
61	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	host	host	NN	NN	_	11	compound	_	_
8	transcription	transcription	NN	NN	_	11	compound	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	4	nmod	_	_
12	-LSB-	-lsb-	-LRB-	-LRB-	_	13	punct	_	_
13	G.Nabel	G.Nabel	NNP	NNP	_	4	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	D.Baltimore	D.Baltimore	NNP	NNP	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	Nature	Nature	NNP	NNP	_	19	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	London	London	NNP	NNP	_	13	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	326	326	CD	CD	_	19	nummod	_	_
22	:	:	:	:	_	19	punct	_	_
23	711-717	711-717	CD	CD	_	19	nummod	_	_
24	,	,	,	,	_	13	punct	_	_
25	1987	1987	CD	CD	_	13	amod	_	_
26	-RSB-	-rsb-	-RRB-	-RRB-	_	13	punct	_	_
27	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	HIV-1-encoded	hiv-1-encoded	JJ	JJ	_	8	amod	_	_
7	Nef	nef	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	9	nsubj	_	_
9	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	11	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	mitogens	mitogen	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	Nef	nef	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affect	affect	VB	VB	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	implicated	implicate	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	including	include	VBG	VBG	_	20	case	_	_
20	SP-1	sp-1	NN	NN	_	13	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	USF	usf	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	URS	urs	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	NF-AT	nf-at	NN	NN	_	20	conj	_	_
28	.	.	.	.	_	6	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Nef	nef	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	induction	induction	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	HIV-1-	hiv-1-	NN	NN	_	13	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	interleukin	interleukin	NN	NN	_	11	nmod:npmod	_	_
11	2-directed	2-directed	JJ	JJ	_	8	conj	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	effect	effect	NN	NN	_	21	nsubj	_	_
18	on	on	IN	IN	_	20	case	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	17	nmod	_	_
21	depends	depend	VBZ	VBZ	_	4	conj	_	_
22	on	on	IN	IN	_	27	case	_	_
23	an	a	DT	DT	_	27	det	_	_
24	intact	intact	JJ	JJ	_	27	amod	_	_
25	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
26	B-binding	b-binding	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	defective	defective	JJ	JJ	_	6	amod	_	_
6	recruitment	recruitment	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	underlie	underlie	VB	VB	_	3	ccomp	_	_
12	Nef	nef	NN	NN	_	16	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	negative	negative	JJ	JJ	_	16	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	11	dobj	_	_
17	on	on	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	HIV-1	hiv-1	NN	NN	_	23	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	interleukin	interleukin	NN	NN	_	19	conj	_	_
22	2	2	CD	CD	_	21	nummod	_	_
23	promoters	promoter	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Nef	nef	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	interfering	interfere	VBG	VBG	_	6	advcl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	signal	signal	NN	NN	_	11	nmod	_	_
15	derived	derive	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	T-cell	t-cell	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	antihypertensive	antihypertensive	JJ	JJ	_	5	amod	_	_
5	therapy	therapy	NN	NN	_	2	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	captopril	captopril	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	12	case	_	_
9	gluco-	gluco-	JJ	JJ	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	mineralocorticoid	mineralocorticoid	NN	NN	_	9	conj	_	_
12	receptors	receptor	NNS	NNS	_	2	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	hypertensive	hypertensive	JJ	JJ	_	19	amod	_	_
19	patients	patient	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	various	various	JJ	JJ	_	22	amod	_	_
22	age	age	NN	NN	_	19	nmod	_	_
23	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	Binding	binding	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	3H-dexamethasone	3h-dexamethasone	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	3H-aldosterone	3h-aldosterone	NN	NN	_	3	conj	_	_
6	by	by	IN	IN	_	9	case	_	_
7	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	1	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	investigated	investigate	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	persons	person	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	hypertensive	hypertensive	JJ	JJ	_	17	amod	_	_
17	patients	patient	NNS	NNS	_	14	conj	_	_
18	before	before	IN	IN	_	23	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	after	after	IN	IN	_	18	conj	_	_
21	2-week	2-week	JJ	JJ	_	23	amod	_	_
22	captopril	captopril	NN	NN	_	23	compound	_	_
23	treatment	treatment	NN	NN	_	11	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	mineralocorticoid	mineralocorticoid	NN	NN	_	4	conj	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	increased	increase	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	hypertensives	hypertensive	NNS	NNS	_	10	nmod	_	_
13	vs	vs	CC	CC	_	12	cc	_	_
14	normotensives	normotensive	NNS	NNS	_	12	conj	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	treatment	treatment	NN	NN	_	8	nsubj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	ACE	ace	NN	NN	_	7	compound	_	_
6	inhibitor	inhibitor	NN	NN	_	7	compound	_	_
7	captopril	captopril	NN	NN	_	2	nmod	_	_
8	led	lead	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	hormone-receptor	hormone-receptor	NN	NN	_	13	compound	_	_
13	interactions	interaction	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	more	more	RBR	RBR	_	5	advmod	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	rise	rise	NN	NN	_	2	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	receptors	receptor	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	18	case	_	_
13	middle-aged	middle-aged	JJ	JJ	_	18	amod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	44-55	44-55	CD	CD	_	16	nummod	_	_
16	years	year	NNS	NNS	_	13	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	hypertensives	hypertensive	NNS	NNS	_	6	nmod	_	_
19	vs	vs	CC	CC	_	18	cc	_	_
20	elderly	elderly	JJ	JJ	_	25	amod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	61-80	61-80	CD	CD	_	23	nummod	_	_
23	years	year	NNS	NNS	_	20	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	subjects	subject	NNS	NNS	_	18	conj	_	_
26	after	after	IN	IN	_	28	case	_	_
27	captopril	captopril	NN	NN	_	28	compound	_	_
28	treatment	treatment	NN	NN	_	2	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Leukotriene	leukotriene	NN	NN	_	2	compound	_	_
2	B4	b4	NN	NN	_	4	nsubj	_	_
3	transcriptionally	transcriptionally	RB	RB	_	4	advmod	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	interleukin-6	interleukin-6	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	involving	involve	VBG	VBG	_	6	acl	_	_
8	NK-chi	nk-chi	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-IL6	nf-il6	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Leukotriene	leukotriene	NN	NN	_	2	compound	_	_
2	B4	b4	NN	NN	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	LTB4	ltb4	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	notable	notable	JJ	JJ	_	9	amod	_	_
9	participant	participant	NN	NN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	inflammation	inflammation	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	chemotaxis	chemotaxis	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	,	,	,	,	_	7	punct	_	_
4	however	however	RB	RB	_	7	advmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	still	still	RB	RB	_	7	advmod	_	_
7	unclear	unclear	JJ	JJ	_	0	root	_	_
8	whether	whether	IN	IN	_	10	mark	_	_
9	LTB4	ltb4	NN	NN	_	10	nsubj	_	_
10	acts	act	VBZ	VBZ	_	7	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	regard	regard	NN	NN	_	10	nmod	_	_
14	directly	directly	RB	RB	_	15	advmod	_	_
15	or	or	CC	CC	_	10	advmod	_	_
16	indirectly	indirectly	RB	RB	_	15	advmod	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	stimulating	stimulate	VBG	VBG	_	10	advcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	release	release	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	chemotactic	chemotactic	JJ	JJ	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	inflammatory	inflammatory	JJ	JJ	_	22	conj	_	_
25	cytokines	cytokine	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	LTB4	ltb4	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	synthesis	synthesis	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	interleukin	interleukin	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL	il	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	-6	-6	CD	CD	_	9	nummod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
18	through	through	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	6	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IL-6	il-6	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	furthermore	furthermore	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	process	process	NN	NN	_	7	nsubj	_	_
7	involves	involve	VBZ	VBZ	_	3	ccomp	_	_
8	activation	activation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	transcription	transcription	NN	NN	_	14	compound	_	_
12	factor	factor	NN	NN	_	14	compound	_	_
13	NF-chi	nf-chi	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	,	,	,	,	_	23	punct	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	lesser	lesser	JJR	JJR	_	20	amod	_	_
20	extent	extent	NN	NN	_	23	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-IL6	nf-il6	NN	NN	_	7	conj	_	_
24	,	,	,	,	_	7	punct	_	_
25	while	while	IN	IN	_	41	dep	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activity	activity	NN	NN	_	41	dep	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	transcription	transcription	NN	NN	_	32	compound	_	_
31	factor	factor	NN	NN	_	32	compound	_	_
32	AP-1	ap-1	NN	NN	_	27	nmod	_	_
33	,	,	,	,	_	27	punct	_	_
34	shown	show	VBN	VBN	_	27	acl	_	_
35	to	to	TO	TO	_	37	mark	_	_
36	otherwise	otherwise	RB	RB	_	37	advmod	_	_
37	confer	confer	VB	VB	_	34	xcomp	_	_
38	IL-6	il-6	NN	NN	_	39	compound	_	_
39	inducibility	inducibility	NN	NN	_	37	dobj	_	_
40	,	,	,	,	_	27	punct	_	_
41	appeared	appear	VBD	VBD	_	7	advcl	_	_
42	to	to	TO	TO	_	44	mark	_	_
43	be	be	VB	VB	_	44	aux	_	_
44	unaffected	unaffected	JJ	JJ	_	41	xcomp	_	_
45	by	by	IN	IN	_	46	case	_	_
46	LTB4	ltb4	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	3	punct	_	_

1	Involvement	involvement	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-chi	nf-chi	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-IL6	nf-il6	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	induction	induction	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IL-6	il-6	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
16	using	use	VBG	VBG	_	15	xcomp	_	_
17	deleted	deleted	JJ	JJ	_	18	amod	_	_
18	forms	form	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-6	il-6	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	IL-6	il-6	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	LTB4	ltb4	NN	NN	_	1	nmod	_	_
8	was	be	VBD	VBD	_	0	root	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	8	dep	_	_
11	associated	associate	VBN	VBN	_	8	conj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	accumulation	accumulation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	respective	respective	JJ	JJ	_	17	amod	_	_
17	transcripts	transcript	NNS	NNS	_	13	nmod	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	resulted	result	VBD	VBD	_	8	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	synthesis	synthesis	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	functional	functional	JJ	JJ	_	25	amod	_	_
24	IL-6	il-6	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	as	as	RB	RB	_	27	advmod	_	_
27	well	well	RB	RB	_	19	advcl	_	_
28	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	LTB4	ltb4	NN	NN	_	5	nsubj	_	_
5	mediated	mediate	VBD	VBD	_	0	root	_	_
6	transactivation	transactivation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	heterologous	heterologous	JJ	JJ	_	11	amod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	construct	construct	NN	NN	_	6	nmod	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	NF-chi	nf-chi	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	NF-IL6	nf-il6	NN	NN	_	15	conj	_	_
19	enhancer	enhancer	NN	NN	_	15	dep	_	_
20	,	,	,	,	_	15	punct	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	15	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	AP-1	ap-1	NN	NN	_	25	compound	_	_
25	enhancer	enhancer	NN	NN	_	15	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	signaling	signaling	NN	NN	_	3	compound	_	_
3	events	event	NNS	NNS	_	7	nsubj	_	_
4	mediating	mediate	VBG	VBG	_	3	acl	_	_
5	this	this	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	appeared	appear	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	involve	involve	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	release	release	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	H2O2	h2o2	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	since	since	IN	IN	_	17	mark	_	_
16	LTB4	ltb4	NN	NN	_	17	nsubj	_	_
17	failed	fail	VBD	VBD	_	9	advcl	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	induce	induce	VB	VB	_	17	xcomp	_	_
20	NF-chi	nf-chi	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	19	dobj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	NF-IL6	nf-il6	NN	NN	_	21	conj	_	_
24	in	in	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	dep	_	_
26	presence	presence	NN	NN	_	29	dep	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	scavenger	scavenger	NN	NN	_	19	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	H2O2	h2o2	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	29	punct	_	_
33	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	29	appos	_	_
34	.	.	.	.	_	7	punct	_	_

1	Estrogen	estrogen	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	effects	effect	NNS	NNS	_	3	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	danazol	danazol	NN	NN	_	9	nmod	_	_
12	on	on	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	sites	site	NNS	NNS	_	9	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	14	advmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	1	1	LS	LS	_	6	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	This	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	designed	design	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	investigate	investigate	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	33	case	_	_
12	estrogen	estrogen	NN	NN	_	33	compound	_	_
13	type	type	NN	NN	_	33	compound	_	_
14	I	i	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	high	high	JJ	JJ	_	17	amod	_	_
17	affinity	affinity	NN	NN	_	13	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	low	low	JJ	JJ	_	20	amod	_	_
20	capacity	capacity	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	type	type	NN	NN	_	13	conj	_	_
24	II	ii	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	low	low	JJ	JJ	_	27	amod	_	_
27	affinity	affinity	NN	NN	_	23	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	high	high	JJ	JJ	_	30	amod	_	_
30	capacity	capacity	NN	NN	_	27	appos	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	binding	binding	NN	NN	_	33	compound	_	_
33	sites	site	NNS	NNS	_	10	nmod	_	_
34	in	in	IN	IN	_	38	case	_	_
35	human	human	JJ	JJ	_	38	amod	_	_
36	peripheral	peripheral	JJ	JJ	_	38	amod	_	_
37	blood	blood	NN	NN	_	38	compound	_	_
38	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
39	and	and	CC	CC	_	10	cc	_	_
40	the	the	DT	DT	_	41	det	_	_
41	effects	effect	NNS	NNS	_	10	conj	_	_
42	of	of	IN	IN	_	43	case	_	_
43	danazol	danazol	NN	NN	_	41	nmod	_	_
44	on	on	IN	IN	_	46	case	_	_
45	these	these	DT	DT	_	46	det	_	_
46	sites	site	NNS	NNS	_	41	nmod	_	_
47	.	.	.	.	_	6	punct	_	_

1	2	2	LS	LS	_	10	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	These	these	DT	DT	_	5	det	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	types	type	NNS	NNS	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	estrogen	estrogen	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	5	nmod	_	_
10	existed	exist	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	3	3	LS	LS	_	4	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Danazol	danazol	NN	NN	_	4	nsubj	_	_
4	bound	bind	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	sites	site	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	concentration	concentration	NN	NN	_	4	nmod	_	_
11	(	(	-LRB-	-LRB-	_	17	punct	_	_
12	10(-6)	10(-6)	CD	CD	_	13	nummod	_	_
13	M	m	NN	NN	_	17	compound	_	_
14	,	,	,	,	_	13	punct	_	_
15	clinical	clinical	JJ	JJ	_	13	amod	_	_
16	serum	serum	NN	NN	_	17	compound	_	_
17	concentration	concentration	NN	NN	_	10	dep	_	_
18	during	during	IN	IN	_	20	case	_	_
19	danazol	danazol	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	and	and	CC	CC	_	4	cc	_	_
23	decreased	decrease	VBD	VBD	_	4	conj	_	_
24	the	the	DT	DT	_	25	det	_	_
25	number	number	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	both	both	DT	DT	_	28	det	_	_
28	sites	site	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	4	4	LS	LS	_	5	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	It	it	PRP	PRP	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	suggested	suggest	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	danazol	danazol	NN	NN	_	8	nsubj	_	_
8	has	have	VBZ	VBZ	_	5	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	anti-estrogenic	anti-estrogenic	JJ	JJ	_	11	amod	_	_
11	action	action	NN	NN	_	8	dobj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	through	through	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	competition	competition	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	suppression	suppression	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	estrogen	estrogen	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	17	nmod	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	seen	see	VBN	VBN	_	8	advcl	_	_
26	in	in	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	estrogen	estrogen	NN	NN	_	30	compound	_	_
29	target	target	NN	NN	_	30	compound	_	_
30	organ	organ	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Mechanism	mechanism	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	action	action	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	11	case	_	_
6	steroid	steroid	NN	NN	_	11	compound	_	_
7	hormones	hormone	NNS	NNS	_	11	compound	_	_
8	.	.	.	.	_	11	punct	_	_
9	I	i	LS	LS	_	11	dep	_	_
10	.	.	.	.	_	11	punct	_	_
11	Estrogens	estrogen	NNS	NNS	_	4	nmod	_	_
12	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	steroid	steroid	NN	NN	_	3	compound	_	_
3	hormone	hormone	NN	NN	_	7	nsubj	_	_
4	are	be	VBP	VBP	_	7	cop	_	_
5	very	very	RB	RB	_	6	advmod	_	_
6	versatile	versatile	JJ	JJ	_	7	amod	_	_
7	molecules	molecule	NNS	NNS	_	0	root	_	_
8	:	:	:	:	_	7	punct	_	_
9	although	although	IN	IN	_	12	mark	_	_
10	they	they	PRP	PRP	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	related	related	JJ	JJ	_	21	advcl	_	_
13	among	among	IN	IN	_	14	case	_	_
14	them	they	PRP	PRP	_	12	nmod	_	_
15	by	by	IN	IN	_	18	case	_	_
16	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
17	chemical	chemical	JJ	JJ	_	18	amod	_	_
18	structure	structure	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	have	have	VBP	VBP	_	7	parataxis	_	_
22	very	very	RB	RB	_	23	advmod	_	_
23	diverse	diverse	JJ	JJ	_	24	amod	_	_
24	functions	function	NNS	NNS	_	21	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	antagonic	antagonic	JJ	JJ	_	24	conj	_	_
28	.	.	.	.	_	21	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	action	action	NN	NN	_	3	compound	_	_
3	mechanism	mechanism	NN	NN	_	7	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	7	auxpass	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	completely	completely	RB	RB	_	7	advmod	_	_
7	cleared	clear	VBN	VBN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	estrogens	estrogen	NNS	NNS	_	3	nsubj	_	_
3	participate	participate	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regulation	regulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	14	case	_	_
8	practically	practically	RB	RB	_	9	advmod	_	_
9	all	all	PDT	PDT	_	14	nummod	_	_
10	the	the	DT	DT	_	14	det	_	_
11	reproductive	reproductive	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sexual	sexual	JJ	JJ	_	11	conj	_	_
14	events	event	NNS	NNS	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	female	female	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	although	although	IN	IN	_	31	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	intracellular	intracellular	JJ	JJ	_	22	amod	_	_
22	actions	action	NNS	NNS	_	31	nsubjpass	_	_
23	by	by	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	26	nmod	_	_
25	they	they	PRP	PRP	_	26	nsubj	_	_
26	take	take	VBP	VBP	_	22	acl:relcl	_	_
27	place	place	NN	NN	_	26	dobj	_	_
28	are	be	VBP	VBP	_	31	auxpass	_	_
29	not	not	RB	RB	_	31	neg	_	_
30	well	well	RB	RB	_	31	advmod	_	_
31	known	know	VBN	VBN	_	3	advcl	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	35	det	_	_
34	proposed	proposed	JJ	JJ	_	35	amod	_	_
35	models	model	NNS	NNS	_	39	nsubj	_	_
36	do	do	VBP	VBP	_	39	aux	_	_
37	not	not	RB	RB	_	39	neg	_	_
38	adequately	adequately	RB	RB	_	39	advmod	_	_
39	satisfy	satisfy	VB	VB	_	31	conj	_	_
40	the	the	DT	DT	_	41	det	_	_
41	questions	question	NNS	NNS	_	39	dobj	_	_
42	.	.	.	.	_	3	punct	_	_

1	Currently	currently	RB	RB	_	4	advmod	_	_
2	it	it	PRP	PRP	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	accepted	accept	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	existence	existence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
10	and/or	and/or	CC	CC	_	9	cc	_	_
11	nuclear	nuclear	JJ	JJ	_	9	conj	_	_
12	receptor	receptor	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	without	without	IN	IN	_	15	mark	_	_
15	explaining	explain	VBG	VBG	_	4	advcl	_	_
16	satisfactorily	satisfactorily	RB	RB	_	15	advmod	_	_
17	how	how	WRB	WRB	_	20	advmod	_	_
18	the	the	DT	DT	_	19	det	_	_
19	hormones	hormone	NNS	NNS	_	20	nsubj	_	_
20	come	come	VBN	VBN	_	15	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	nucleus	nucleus	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	endocrine	endocrine	JJ	JJ	_	3	amod	_	_
3	events	event	NNS	NNS	_	16	nsubj	_	_
4	that	that	WDT	WDT	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	rapidly	rapidly	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	3	acl:relcl	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	seconds	seconds	NNS	NNS	_	7	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	are	be	VBP	VBP	_	16	cop	_	_
12	due	due	JJ	JJ	_	16	case	_	_
13	to	to	TO	TO	_	12	mwe	_	_
14	a	a	DT	DT	_	16	det	_	_
15	possible	possible	JJ	JJ	_	16	amod	_	_
16	interaction	interaction	NN	NN	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	membrane	membrane	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	review	review	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	analyze	analyze	VB	VB	_	6	xcomp	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	concilliate	concilliate	VB	VB	_	8	conj	_	_
11	the	the	DT	DT	_	13	det	_	_
12	reported	report	VBN	VBN	_	13	amod	_	_
13	data	datum	NNS	NNS	_	8	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mechanism	mechanism	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	action	action	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	estrogens	estrogen	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Stable	stable	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	transdominant	transdominant	JJ	JJ	_	6	amod	_	_
5	Rev	rev	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	15	compound	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
4	virus	virus	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIV	hiv	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	Rev	rev	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	essential	essential	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	16	case	_	_
13	viral	viral	JJ	JJ	_	16	amod	_	_
14	structural	structural	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Gag	gag	NN	NN	_	16	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	Pol	pol	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	Env	env	NN	NN	_	18	conj	_	_
24	)	)	-RRB-	-RRB-	_	18	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	,	,	,	,	_	16	punct	_	_
27	hence	hence	RB	RB	_	16	conj	_	_
28	,	,	,	,	_	16	punct	_	_
29	for	for	IN	IN	_	31	case	_	_
30	viral	viral	JJ	JJ	_	31	amod	_	_
31	replication	replication	NN	NN	_	16	conj	_	_
32	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	mutant	mutant	JJ	JJ	_	7	amod	_	_
7	forms	form	NNS	NNS	_	12	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Rev	rev	NN	NN	_	7	nmod	_	_
10	have	have	VBP	VBP	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	inhibit	inhibit	VBP	VBP	_	12	ccomp	_	_
15	wild-type	wild-type	JJ	JJ	_	17	amod	_	_
16	Rev	rev	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	14	dobj	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	therefore	therefore	RB	RB	_	14	advmod	_	_
20	suppress	suppress	VBP	VBP	_	14	dep	_	_
21	viral	viral	JJ	JJ	_	22	amod	_	_
22	replication	replication	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	27	advcl	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	such	such	JJ	JJ	_	7	amod	_	_
5	transdominant	transdominant	JJ	JJ	_	7	amod	_	_
6	Rev	rev	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	9	nsubj	_	_
8	could	could	MD	MD	_	9	aux	_	_
9	provide	provide	VB	VB	_	2	ccomp	_	_
10	long-term	long-term	JJ	JJ	_	11	amod	_	_
11	protection	protection	NN	NN	_	9	dobj	_	_
12	against	against	IN	IN	_	14	case	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	infection	infection	NN	NN	_	11	nmod	_	_
15	without	without	IN	IN	_	16	mark	_	_
16	affecting	affect	VBG	VBG	_	9	advcl	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	27	punct	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	leukemia	leukemia	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	27	nsubjpass	_	_
25	were	be	VBD	VBD	_	27	auxpass	_	_
26	stably	stably	RB	RB	_	27	advmod	_	_
27	transduced	transduce	VBN	VBN	_	0	root	_	_
28	with	with	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	retroviral	retroviral	JJ	JJ	_	31	amod	_	_
31	vector	vector	NN	NN	_	27	nmod	_	_
32	encoding	encode	VBG	VBG	_	31	acl	_	_
33	a	a	DT	DT	_	35	det	_	_
34	transdominant	transdominant	JJ	JJ	_	35	amod	_	_
35	mutant	mutant	NN	NN	_	32	dobj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	Rev	rev	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	35	nmod	_	_
40	,	,	,	,	_	35	punct	_	_
41	M10	m10	NN	NN	_	35	appos	_	_
42	.	.	.	.	_	27	punct	_	_

1	While	while	IN	IN	_	7	mark	_	_
2	all	all	PDT	PDT	_	6	det:predet	_	_
3	the	the	DT	DT	_	6	det	_	_
4	M10-expressing	m10-expressing	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	7	nsubj	_	_
7	remained	remain	VBD	VBD	_	15	advcl	_	_
8	infectable	infectable	JJ	JJ	_	7	xcomp	_	_
9	by	by	IN	IN	_	10	case	_	_
10	HIV-1	hiv-1	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	these	these	DT	DT	_	14	det	_	_
13	same	same	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	15	nsubj	_	_
15	failed	fail	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	support	support	VB	VB	_	15	xcomp	_	_
18	a	a	DT	DT	_	21	det	_	_
19	productive	productive	JJ	JJ	_	21	amod	_	_
20	replication	replication	NN	NN	_	21	compound	_	_
21	cycle	cycle	NN	NN	_	17	dobj	_	_
22	when	when	WRB	WRB	_	23	advmod	_	_
23	infected	infect	VBN	VBN	_	17	advcl	_	_
24	with	with	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	cloned	clone	VBN	VBN	_	27	amod	_	_
27	isolate	isolate	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	HIV-1	hiv-1	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	two	two	CD	CD	_	7	compound	_	_
5	out	out	IN	IN	_	7	advmod	_	_
6	of	of	IN	IN	_	7	advmod	_	_
7	three	three	CD	CD	_	10	nummod	_	_
8	M10-expressing	m10-expressing	JJ	JJ	_	10	amod	_	_
9	CEM	cem	NN	NN	_	10	compound	_	_
10	clones	clone	NNS	NNS	_	13	nsubj	_	_
11	were	be	VBD	VBD	_	13	cop	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	resistant	resistant	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	17	case	_	_
15	highly	highly	RB	RB	_	16	advmod	_	_
16	productive	productive	JJ	JJ	_	17	amod	_	_
17	infection	infection	NN	NN	_	13	nmod	_	_
18	by	by	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	heterogeneous	heterogeneous	JJ	JJ	_	22	amod	_	_
21	HIV-1	hiv-1	NN	NN	_	22	compound	_	_
22	pool	pool	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Expression	expression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	M10	m10	NN	NN	_	1	nmod	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affect	affect	VB	VB	_	0	root	_	_
7	induction	induction	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	7	nmod	_	_
11	mediated	mediate	VBN	VBN	_	7	acl	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	kappa	kappa	NN	NN	_	17	compound	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	11	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	Tat	tat	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Importantly	importantly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	constitutive	constitutive	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Rev	rev	NN	NN	_	7	compound	_	_
7	M10	m10	NN	NN	_	4	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	alter	alter	VB	VB	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	secretion	secretion	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	interleukin	interleukin	NN	NN	_	12	nmod	_	_
15	2	2	CD	CD	_	14	nummod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	response	response	NN	NN	_	20	dep	_	_
18	to	to	TO	TO	_	20	case	_	_
19	mitogen	mitogen	NN	NN	_	20	compound	_	_
20	stimulation	stimulation	NN	NN	_	10	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	EL-4	el-4	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Jurkat	jurkat	NN	NN	_	22	conj	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	27	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	stably	stably	RB	RB	_	9	advmod	_	_
9	expressing	express	VBG	VBG	_	7	acl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	transdominant	transdominant	JJ	JJ	_	13	amod	_	_
12	Rev	rev	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	9	dobj	_	_
14	,	,	,	,	_	2	punct	_	_
15	in	in	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	dep	_	_
17	absence	absence	NN	NN	_	21	dep	_	_
18	of	of	IN	IN	_	21	case	_	_
19	any	any	DT	DT	_	21	det	_	_
20	deleterious	deleterious	JJ	JJ	_	21	amod	_	_
21	effect	effect	NN	NN	_	2	nmod	_	_
22	on	on	IN	IN	_	25	case	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	function	function	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	2	punct	_	_
27	suggests	suggest	VBZ	VBZ	_	0	root	_	_
28	that	that	IN	IN	_	33	mark	_	_
29	such	such	PDT	PDT	_	31	det:predet	_	_
30	a	a	DT	DT	_	31	det	_	_
31	strategy	strategy	NN	NN	_	33	nsubj	_	_
32	could	could	MD	MD	_	33	aux	_	_
33	provide	provide	VB	VB	_	27	ccomp	_	_
34	a	a	DT	DT	_	36	det	_	_
35	therapeutic	therapeutic	JJ	JJ	_	36	amod	_	_
36	effect	effect	NN	NN	_	33	dobj	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	lymphocytes	lymphocyte	NNS	NNS	_	33	nmod	_	_
41	of	of	IN	IN	_	45	case	_	_
42	acquired	acquire	VBN	VBN	_	45	amod	_	_
43	immunodeficiency	immunodeficiency	NN	NN	_	45	compound	_	_
44	syndrome	syndrome	NN	NN	_	45	compound	_	_
45	patients	patient	NNS	NNS	_	40	nmod	_	_
46	.	.	.	.	_	27	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	lupus	lupus	NN	NN	_	7	compound	_	_
7	nephritis	nephritis	NN	NN	_	4	nmod	_	_
8	:	:	:	:	_	2	punct	_	_
9	relationship	relationship	NN	NN	_	2	dep	_	_
10	between	between	IN	IN	_	12	case	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	leukocytes	leukocyte	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	effect	effect	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	clinical	clinical	JJ	JJ	_	5	amod	_	_
5	significance	significance	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	determination	determination	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	20	20	CD	CD	_	12	nummod	_	_
12	patients	patient	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	systemic	systemic	JJ	JJ	_	16	amod	_	_
15	lupus	lupus	NN	NN	_	16	compound	_	_
16	erythematosus	erythematosus	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	SLE	sle	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	who	who	WP	WP	_	22	nsubj	_	_
21	afterwards	afterwards	RB	RB	_	22	advmod	_	_
22	developed	develop	VBD	VBD	_	12	acl:relcl	_	_
23	nephrotic	nephrotic	JJ	JJ	_	24	amod	_	_
24	syndrome	syndrome	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	concentrations	concentration	NNS	NNS	_	14	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
6	leukocytes	leukocyte	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	MNL	mnl	NNS	NNS	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	patients	patient	NNS	NNS	_	3	nmod	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	comparable	comparable	JJ	JJ	_	0	root	_	_
15	with	with	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	14	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	other	other	JJ	JJ	_	20	amod	_	_
20	patients	patient	NNS	NNS	_	16	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	SLE	sle	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	healthy	healthy	JJ	JJ	_	25	amod	_	_
25	persons	person	NNS	NNS	_	20	conj	_	_
26	.	.	.	.	_	14	punct	_	_

1	Improvement	improvement	NN	NN	_	29	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	urinary	urinary	JJ	JJ	_	5	amod	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	excretion	excretion	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	in	in	IN	IN	_	9	case	_	_
8	disease	disease	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	1	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	scored	score	VBN	VBN	_	1	acl:relcl	_	_
14	according	accord	VBG	VBG	_	21	case	_	_
15	to	to	TO	TO	_	14	mwe	_	_
16	the	the	DT	DT	_	21	det	_	_
17	SLE	SLE	NNP	NNP	_	21	compound	_	_
18	Disease	Disease	NNP	NNP	_	21	compound	_	_
19	Activity	Activity	NNP	NNP	_	21	compound	_	_
20	Index	Index	NNP	NNP	_	21	compound	_	_
21	system	system	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	University	University	NNP	NNP	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Toronto	Toronto	NNP	NNP	_	24	nmod	_	_
27	,	,	,	,	_	1	punct	_	_
28	closely	closely	RB	RB	_	29	advmod	_	_
29	related	related	JJ	JJ	_	0	root	_	_
30	to	to	TO	TO	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	glucocorticoid	glucocorticoid	NN	NN	_	34	compound	_	_
33	receptor	receptor	NN	NN	_	34	compound	_	_
34	concentrations	concentration	NNS	NNS	_	29	nmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	MNL	mnl	NN	NN	_	34	nmod	_	_
37	isolated	isolate	VBN	VBN	_	36	acl	_	_
38	from	from	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	corresponding	corresponding	JJ	JJ	_	41	amod	_	_
41	patients	patient	NNS	NNS	_	37	nmod	_	_
42	.	.	.	.	_	29	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	determination	determination	NN	NN	_	16	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	lupus	lupus	NN	NN	_	11	compound	_	_
11	nephritis	nephritis	NN	NN	_	8	nmod	_	_
12	may	may	MD	MD	_	16	aux	_	_
13	be	be	VB	VB	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	predictive	predictive	JJ	JJ	_	16	amod	_	_
16	clue	clue	NN	NN	_	0	root	_	_
17	for	for	IN	IN	_	18	mark	_	_
18	assessing	assess	VBG	VBG	_	16	acl	_	_
19	responsiveness	responsiveness	NN	NN	_	18	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	therapy	therapy	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	Selection	selection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	optimal	optimal	JJ	JJ	_	7	amod	_	_
4	kappa	kappa	NN	NN	_	5	dep	_	_
5	B/Rel	b/rel	NN	NN	_	7	amod	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	motifs	motif	NNS	NNS	_	1	nmod	_	_
8	:	:	:	:	_	1	punct	_	_
9	interaction	interaction	NN	NN	_	19	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	subunits	subunit	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	DNA	dna	NN	NN	_	9	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	1	dep	_	_
20	for	for	IN	IN	_	22	case	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	19	punct	_	_

1	Analysis	analysis	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	p50	p50	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p65	p65	NN	NN	_	4	conj	_	_
7	subunits	subunit	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	7	nmod	_	_
15	has	have	VBZ	VBZ	_	16	aux	_	_
16	revealed	reveal	VBN	VBN	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	both	both	DT	DT	_	19	det	_	_
19	proteins	protein	NNS	NNS	_	21	nsubj	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	interact	interact	VB	VB	_	16	ccomp	_	_
22	with	with	IN	IN	_	25	case	_	_
23	related	related	JJ	JJ	_	25	amod	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	sequences	sequence	NNS	NNS	_	21	nmod	_	_
26	through	through	IN	IN	_	31	case	_	_
27	either	either	CC	CC	_	28	cc:preconj	_	_
28	homo-	homo-	JJ	JJ	_	31	compound	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	heterodimer	heterodimer	NN	NN	_	28	conj	_	_
31	formation	formation	NN	NN	_	21	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	product	product	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	proto-oncogene	proto-oncogene	NN	NN	_	9	compound	_	_
9	c-rel	c-rel	NN	NN	_	5	nmod	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	bind	bind	VB	VB	_	0	root	_	_
12	to	to	TO	TO	_	15	case	_	_
13	similar	similar	JJ	JJ	_	15	amod	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	11	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	itself	itself	PRP	PRP	_	11	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	as	as	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	heterodimer	heterodimer	NN	NN	_	17	conj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	p50	p50	NN	NN	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	p65	p65	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	limited	limited	JJ	JJ	_	9	amod	_	_
9	number	number	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	known	known	JJ	JJ	_	15	amod	_	_
12	kappa	kappa	NN	NN	_	15	compound	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	question	question	NN	NN	_	32	nsubjpass	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	optimal	optimal	JJ	JJ	_	24	amod	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	sequences	sequence	NNS	NNS	_	19	nmod	_	_
25	preferred	prefer	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	each	each	DT	DT	_	28	det	_	_
28	homodimer	homodimer	NN	NN	_	25	nmod	_	_
29	has	have	VBZ	VBZ	_	32	aux	_	_
30	not	not	RB	RB	_	32	neg	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	addressed	address	VBN	VBN	_	6	conj	_	_
33	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	16	advcl	_	_
2	purified	purify	VBN	VBN	_	10	amod	_	_
3	recombinant	recombinant	JJ	JJ	_	10	amod	_	_
4	p50	p50	NN	NN	_	10	compound	_	_
5	,	,	,	,	_	4	punct	_	_
6	p65	p65	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	c-Rel	c-rel	NN	NN	_	4	conj	_	_
10	proteins	protein	NNS	NNS	_	1	dobj	_	_
11	,	,	,	,	_	16	punct	_	_
12	optimal	optimal	JJ	JJ	_	14	amod	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	motifs	motif	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	selected	select	VBN	VBN	_	0	root	_	_
17	from	from	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	pool	pool	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	random	random	JJ	JJ	_	22	amod	_	_
22	oligonucleotides	oligonucleotide	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	Alignment	alignment	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	selected	select	VBN	VBN	_	5	amod	_	_
5	sequences	sequence	NNS	NNS	_	1	nmod	_	_
6	allowed	allow	VBD	VBD	_	0	root	_	_
7	us	we	PRP	PRP	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	predict	predict	VB	VB	_	6	xcomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	consensus	consensus	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	9	dobj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	binding	binding	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	individual	individual	JJ	JJ	_	20	amod	_	_
18	homodimeric	homodimeric	JJ	JJ	_	20	amod	_	_
19	Rel-related	rel-related	JJ	JJ	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	6	punct	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	DNA-protein	dna-protein	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	analysis	analysis	NN	NN	_	31	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	selected	select	VBN	VBN	_	29	amod	_	_
29	DNA	dna	NN	NN	_	25	nmod	_	_
30	sequences	sequence	VBZ	VBZ	_	29	dep	_	_
31	revealed	reveal	VBD	VBD	_	6	conj	_	_
32	sequence	sequence	NN	NN	_	33	compound	_	_
33	specificity	specificity	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	proteins	protein	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Contrary	contrary	JJ	JJ	_	4	case	_	_
2	to	to	TO	TO	_	4	case	_	_
3	previous	previous	JJ	JJ	_	4	amod	_	_
4	assumptions	assumption	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	observed	observe	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	p65	p65	NN	NN	_	10	compound	_	_
10	homodimers	homodimer	NNS	NNS	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	interact	interact	VB	VB	_	7	ccomp	_	_
13	with	with	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	subset	subset	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	DNA	dna	NN	NN	_	15	nmod	_	_
18	sequences	sequence	VBZ	VBZ	_	17	dep	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	recognized	recognize	VBN	VBN	_	17	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	p50	p50	NN	NN	_	23	compound	_	_
23	homodimers	homodimer	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Differential	differential	JJ	JJ	_	3	amod	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	affinities	affinity	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	obtained	obtain	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	p50-	p50-	NN	NN	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	c-Rel-selected	c-rel-selected	JJ	JJ	_	8	conj	_	_
11	sequences	sequence	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	27	dep	_	_
2	either	either	CC	CC	_	9	dep	_	_
3	a	a	DT	DT	_	9	det	_	_
4	p50-	p50-	NN	NN	_	9	amod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	p65-selected	p65-selected	JJ	JJ	_	4	conj	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	1	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	displayed	display	VBD	VBD	_	9	acl:relcl	_	_
13	differential	differential	JJ	JJ	_	14	amod	_	_
14	binding	binding	NN	NN	_	12	dobj	_	_
15	with	with	IN	IN	_	20	case	_	_
16	respect	respect	NN	NN	_	20	dep	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	other	other	JJ	JJ	_	20	amod	_	_
20	protein	protein	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	little	little	JJ	JJ	_	25	nummod	_	_
23	to	to	TO	TO	_	22	dep	_	_
24	no	no	DT	DT	_	22	advmod	_	_
25	binding	binding	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	observed	observe	VBN	VBN	_	0	root	_	_
28	with	with	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	heterodimeric	heterodimeric	JJ	JJ	_	33	amod	_	_
31	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	27	punct	_	_

1	Similarly	similarly	RB	RB	_	33	advmod	_	_
2	,	,	,	,	_	33	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	transfection	transfection	NN	NN	_	5	compound	_	_
5	experiments	experiment	NNS	NNS	_	33	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	15	nmod	_	_
8	the	the	DT	DT	_	13	det	_	_
9	selective	selective	JJ	JJ	_	13	amod	_	_
10	kappa	kappa	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	used	use	VBN	VBN	_	5	acl:relcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	drive	drive	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	chloramphenicol	chloramphenicol	NN	NN	_	25	compound	_	_
23	acetyltransferase	acetyltransferase	NN	NN	_	25	compound	_	_
24	reporter	reporter	NN	NN	_	25	compound	_	_
25	construct	construct	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	33	punct	_	_
27	the	the	DT	DT	_	31	det	_	_
28	p65-	p65-	NN	NN	_	31	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	p50-selected	p50-selected	JJ	JJ	_	28	conj	_	_
31	motifs	motif	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	activated	activate	VBN	VBN	_	0	root	_	_
34	only	only	RB	RB	_	58	advmod	_	_
35	in	in	IN	IN	_	58	case	_	_
36	the	the	DT	DT	_	58	dep	_	_
37	presence	presence	NN	NN	_	58	dep	_	_
38	of	of	IN	IN	_	58	case	_	_
39	p65	p65	NN	NN	_	58	compound	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	p50/65	p50/65	NN	NN	_	39	conj	_	_
42	(	(	-LRB-	-LRB-	_	45	punct	_	_
43	a	a	DT	DT	_	45	det	_	_
44	chimeric	chimeric	JJ	JJ	_	45	amod	_	_
45	protein	protein	NN	NN	_	41	dep	_	_
46	with	with	IN	IN	_	51	case	_	_
47	the	the	DT	DT	_	51	det	_	_
48	p50	p50	NN	NN	_	51	compound	_	_
49	DNA	dna	NN	NN	_	51	compound	_	_
50	binding	binding	NN	NN	_	51	compound	_	_
51	domain	domain	NN	NN	_	45	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	p65	p65	NN	NN	_	55	compound	_	_
54	activation	activation	NN	NN	_	55	compound	_	_
55	domain	domain	NN	NN	_	51	conj	_	_
56	)	)	-RRB-	-RRB-	_	45	punct	_	_
57	expression	expression	NN	NN	_	58	compound	_	_
58	vectors	vector	NNS	NNS	_	33	nmod	_	_
59	,	,	,	,	_	33	punct	_	_
60	respectively	respectively	RB	RB	_	33	advmod	_	_
61	,	,	,	,	_	33	punct	_	_
62	and	and	CC	CC	_	33	cc	_	_
63	neither	neither	DT	DT	_	64	nsubj	_	_
64	demonstrated	demonstrate	VBD	VBD	_	33	conj	_	_
65	a	a	DT	DT	_	67	det	_	_
66	significant	significant	JJ	JJ	_	67	amod	_	_
67	response	response	NN	NN	_	64	dobj	_	_
68	to	to	TO	TO	_	69	case	_	_
69	stimuli	stimulus	NNS	NNS	_	67	nmod	_	_
70	that	that	WDT	WDT	_	71	nsubj	_	_
71	induce	induce	VBP	VBP	_	69	acl:relcl	_	_
72	NF-kappa	nf-kappa	NN	NN	_	74	compound	_	_
73	B	b	NN	NN	_	74	compound	_	_
74	activity	activity	NN	NN	_	71	dobj	_	_
75	.	.	.	.	_	33	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	interaction	interaction	NN	NN	_	18	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	both	both	DT	DT	_	8	det	_	_
8	subunits	subunit	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	heterodimeric	heterodimeric	JJ	JJ	_	14	amod	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	8	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	DNA	dna	NN	NN	_	5	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	3	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	binding	binding	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	21	conj	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	suggest	suggest	VBP	VBP	_	3	conj	_	_
27	that	that	IN	IN	_	37	mark	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	37	nsubj	_	_
30	mediated	mediate	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	individual	individual	JJ	JJ	_	35	amod	_	_
34	rel-related	rel-related	JJ	JJ	_	35	amod	_	_
35	proteins	protein	NNS	NNS	_	30	nmod	_	_
36	will	will	MD	MD	_	37	aux	_	_
37	differ	differ	VB	VB	_	26	ccomp	_	_
38	dramatically	dramatically	RB	RB	_	37	advmod	_	_
39	,	,	,	,	_	37	punct	_	_
40	depending	depend	VBG	VBG	_	46	case	_	_
41	on	on	IN	IN	_	46	case	_	_
42	the	the	DT	DT	_	46	det	_	_
43	specific	specific	JJ	JJ	_	46	amod	_	_
44	kappa	kappa	NN	NN	_	46	compound	_	_
45	B	b	NN	NN	_	46	compound	_	_
46	motifs	motif	NNS	NNS	_	37	advcl	_	_
47	present	present	JJ	JJ	_	46	amod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	new	new	JJ	JJ	_	7	amod	_	_
5	tissue-specific	tissue-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	nmod	_	_
8	binding	bind	VBG	VBG	_	7	acl	_	_
9	to	to	TO	TO	_	20	case	_	_
10	the	the	DT	DT	_	20	det	_	_
11	simian	simian	JJ	JJ	_	20	amod	_	_
12	virus	virus	NN	NN	_	20	compound	_	_
13	40	40	CD	CD	_	20	nummod	_	_
14	enhancer	enhancer	NN	NN	_	20	compound	_	_
15	TC-II	tc-ii	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	element	element	NN	NN	_	8	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	6	nsubj	_	_
2	have	have	VBP	VBP	_	6	aux	_	_
3	biochemically	biochemically	RB	RB	_	4	advmod	_	_
4	and	and	CC	CC	_	6	advmod	_	_
5	functionally	functionally	RB	RB	_	4	advmod	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	new	new	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	NP-TCII	np-tcii	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	which	which	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	present	present	JJ	JJ	_	10	acl:relcl	_	_
17	in	in	IN	IN	_	18	case	_	_
18	nuclei	nucleus	NNS	NNS	_	16	nmod	_	_
19	from	from	IN	IN	_	24	case	_	_
20	unstimulated	unstimulated	JJ	JJ	_	24	amod	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	B	b	NN	NN	_	21	conj	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
25	but	but	CC	CC	_	16	cc	_	_
26	is	be	VBZ	VBZ	_	28	auxpass	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	found	find	VBN	VBN	_	16	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	nonhematopoietic	nonhematopoietic	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	6	amod	_	_
6	specificity	specificity	NN	NN	_	3	dobj	_	_
7	similar	similar	JJ	JJ	_	6	amod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	that	that	DT	DT	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	but	but	CC	CC	_	3	cc	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	unrelated	unrelated	JJ	JJ	_	3	conj	_	_
16	to	to	TO	TO	_	21	case	_	_
17	this	this	DT	DT	_	21	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	other	other	JJ	JJ	_	17	conj	_	_
20	Rel	rel	NN	NN	_	21	compound	_	_
21	proteins	protein	NNS	NNS	_	15	nmod	_	_
22	by	by	IN	IN	_	26	case	_	_
23	functional	functional	JJ	JJ	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	biochemical	biochemical	JJ	JJ	_	23	conj	_	_
26	criteria	criterion	NNS	NNS	_	15	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	can	can	MD	MD	_	5	aux	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	distinguished	distinguish	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	12	case	_	_
7	other	other	JJ	JJ	_	12	amod	_	_
8	previously	previously	RB	RB	_	9	advmod	_	_
9	described	describe	VBN	VBN	_	12	amod	_	_
10	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	12	amod	_	_
11	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	5	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	candidate	candidate	NN	NN	_	4	compound	_	_
3	oncoprotein	oncoprotein	NN	NN	_	4	compound	_	_
4	Bcl-3	bcl-3	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	an	a	DT	DT	_	7	det	_	_
7	antagonist	antagonist	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	11	case	_	_
9	p50/NF-kappa	p50/nf-kappa	NN	NN	_	10	nmod:npmod	_	_
10	B-mediated	b-mediated	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	candidate	candidate	NN	NN	_	4	compound	_	_
3	oncogene	oncogene	NN	NN	_	4	compound	_	_
4	bcl-3	bcl-3	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	discovered	discover	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	translocation	translocation	NN	NN	_	6	nmod	_	_
10	into	into	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immunoglobulin	immunoglobulin	NN	NN	_	13	compound	_	_
13	alpha-locus	alpha-locus	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	some	some	DT	DT	_	16	det	_	_
16	cases	case	NNS	NNS	_	6	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	B-cell	b-cell	NN	NN	_	21	compound	_	_
19	chronic	chronic	JJ	JJ	_	21	amod	_	_
20	lymphocytic	lymphocytic	JJ	JJ	_	21	amod	_	_
21	leukaemias	leukaemia	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	Bcl-3	bcl-3	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	seven	seven	CD	CD	_	8	nummod	_	_
6	so-called	so-called	JJ	JJ	_	8	amod	_	_
7	ankyrin	ankyrin	NN	NN	_	8	compound	_	_
8	repeats	repeat	NNS	NNS	_	4	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	3	amod	_	_
2	repeat	repeat	NN	NN	_	3	compound	_	_
3	motifs	motif	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	diverse	diverse	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	but	but	CC	CC	_	5	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	motifs	motif	NNS	NNS	_	21	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Bcl-3	bcl-3	NN	NN	_	15	nmod	_	_
18	are	be	VBP	VBP	_	21	cop	_	_
19	most	most	RBS	RBS	_	20	advmod	_	_
20	closely	closely	RB	RB	_	21	advmod	_	_
21	related	related	JJ	JJ	_	5	conj	_	_
22	to	to	TO	TO	_	23	case	_	_
23	those	those	DT	DT	_	21	nmod	_	_
24	found	find	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	29	case	_	_
26	I	i	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	24	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	which	which	WDT	WDT	_	37	nmod	_	_
32	the	the	DT	DT	_	35	det	_	_
33	ankyrin	ankyrin	NN	NN	_	35	compound	_	_
34	repeat	repeat	NN	NN	_	35	compound	_	_
35	domain	domain	NN	NN	_	37	nsubjpass	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	thought	think	VBN	VBN	_	29	acl:relcl	_	_
38	to	to	TO	TO	_	41	mark	_	_
39	be	be	VB	VB	_	41	auxpass	_	_
40	directly	directly	RB	RB	_	41	advmod	_	_
41	involved	involve	VBN	VBN	_	37	xcomp	_	_
42	in	in	IN	IN	_	43	case	_	_
43	inhibition	inhibition	NN	NN	_	41	nmod	_	_
44	of	of	IN	IN	_	47	case	_	_
45	NF-kappa	nf-kappa	NN	NN	_	47	compound	_	_
46	B	b	NN	NN	_	47	compound	_	_
47	activity	activity	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	5	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	biological	biological	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	7	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	7	aux	_	_
5	yet	yet	RB	RB	_	7	advmod	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	described	describe	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	Bcl-3	bcl-3	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	it	it	PRP	PRP	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	noted	note	VBN	VBN	_	7	conj	_	_
15	recently	recently	RB	RB	_	14	advmod	_	_
16	that	that	IN	IN	_	18	mark	_	_
17	Bcl-3	bcl-3	NN	NN	_	18	nsubj	_	_
18	interferes	interfere	VBZ	VBZ	_	14	ccomp	_	_
19	with	with	IN	IN	_	20	case	_	_
20	DNA-binding	dna-binding	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	p50	p50	NN	NN	_	24	compound	_	_
24	subunit	subunit	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vitro	vitro	FW	FW	_	18	advmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Bcl-3	bcl-3	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	aid	aid	VB	VB	_	3	ccomp	_	_
8	kappa	kappa	NN	NN	_	10	nmod:npmod	_	_
9	B	b	NN	NN	_	10	nmod:npmod	_	_
10	site-dependent	site-dependent	JJ	JJ	_	11	amod	_	_
11	transcription	transcription	NN	NN	_	7	dobj	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	7	advmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	counteracting	counteract	VBG	VBG	_	7	advcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	inhibitory	inhibitory	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	15	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	p50/NF-kappa	p50/nf-kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	homodimers	homodimer	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Bcl-3	bcl-3	NN	NN	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	aid	aid	VB	VB	_	0	root	_	_
5	activation	activation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	select	select	JJ	JJ	_	10	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	nmod:npmod	_	_
9	B-regulated	b-regulated	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	those	those	DT	DT	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
18	virus	virus	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	microtitre	microtitre	NN	NN	_	4	compound	_	_
3	assay	assay	NN	NN	_	4	compound	_	_
4	system	system	NN	NN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	:	:	:	:	_	4	punct	_	_
9	decreased	decrease	VBN	VBN	_	11	amod	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	concentration	concentration	NN	NN	_	4	dep	_	_
12	in	in	IN	IN	_	14	case	_	_
13	myocardial	myocardial	JJ	JJ	_	14	amod	_	_
14	infarction	infarction	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	difficulty	difficulty	NN	NN	_	15	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	determination	determination	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	15	cop	_	_
11	the	the	DT	DT	_	15	det	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	complicated	complicated	JJ	JJ	_	15	amod	_	_
14	assay	assay	NN	NN	_	15	compound	_	_
15	procedure	procedure	NN	NN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	describe	describe	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	microtitre	microtitre	NN	NN	_	8	compound	_	_
7	assay	assay	NN	NN	_	8	compound	_	_
8	system	system	NN	NN	_	4	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	which	which	WDT	WDT	_	18	nsubj	_	_
13	is	be	VBZ	VBZ	_	18	cop	_	_
14	a	a	DT	DT	_	18	det	_	_
15	whole-cell	whole-cell	JJ	JJ	_	18	amod	_	_
16	competitive	competitive	JJ	JJ	_	18	amod	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	radioassay	radioassay	NN	NN	_	8	acl:relcl	_	_
19	using	use	VBG	VBG	_	4	xcomp	_	_
20	-LSB-3H-RSB--dexamethasone	-lsb-3h-rsb--dexamethasone	NN	NN	_	19	dobj	_	_
21	as	as	IN	IN	_	22	case	_	_
22	radioligand	radioligand	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	modification	modification	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	previously	previously	RB	RB	_	6	advmod	_	_
6	described	describe	VBN	VBN	_	7	amod	_	_
7	protocol	protocol	NN	NN	_	2	nmod	_	_
8	simplifies	simplify	VBZ	VBZ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	reduces	reduce	VBZ	VBZ	_	8	conj	_	_
11	laboratory	laboratory	NN	NN	_	12	compound	_	_
12	work	work	NN	NN	_	8	dobj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	allows	allow	VBZ	VBZ	_	8	conj	_	_
15	assay	assay	NN	NN	_	16	compound	_	_
16	reproducibility	reproducibility	NN	NN	_	14	dobj	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	controlled	control	VBN	VBN	_	14	xcomp	_	_
20	more	more	RBR	RBR	_	21	advmod	_	_
21	reliably	reliably	RB	RB	_	19	advmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	2	advmod	_	_
2	enabled	enable	VBN	VBN	_	15	advcl	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	perform	perform	VB	VB	_	2	xcomp	_	_
5	the	the	DT	DT	_	6	det	_	_
6	test	test	NN	NN	_	4	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	multiple	multiple	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	samples	sample	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	parallel	parallel	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	investigated	investigate	VBD	VBD	_	0	root	_	_
16	cardiac	cardiac	JJ	JJ	_	18	amod	_	_
17	infarction	infarction	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	15	dobj	_	_
19	over	over	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	12-day	12-day	JJ	JJ	_	22	amod	_	_
22	period	period	NN	NN	_	15	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	test	test	VB	VB	_	15	advcl	_	_
25	if	if	IN	IN	_	30	mark	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	28	compound	_	_
27	receptor	receptor	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	30	nsubjpass	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	altered	alter	VBN	VBN	_	24	advcl	_	_
31	in	in	IN	IN	_	36	case	_	_
32	this	this	DT	DT	_	36	det	_	_
33	'	'	``	``	_	36	punct	_	_
34	stressful	stressful	JJ	JJ	_	36	amod	_	_
35	'	'	''	''	_	36	punct	_	_
36	disease	disease	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	day	day	NN	NN	_	14	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	disease	disease	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	capacity	capacity	NN	NN	_	14	nsubjpass	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	decreased	decrease	VBN	VBN	_	0	root	_	_
15	without	without	IN	IN	_	16	case	_	_
16	alteration	alteration	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	receptor-ligand	receptor-ligand	JJ	JJ	_	20	amod	_	_
20	affinity	affinity	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	whereas	whereas	IN	IN	_	14	dep	_	_
23	on	on	IN	IN	_	24	case	_	_
24	days	day	NNS	NNS	_	34	nmod	_	_
25	4	4	CD	CD	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	12	12	CD	CD	_	25	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	number	number	NN	NN	_	34	nsubj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	sites	site	NNS	NNS	_	29	nmod	_	_
33	was	be	VBD	VBD	_	34	cop	_	_
34	normal	normal	JJ	JJ	_	14	parataxis	_	_
35	again	again	RB	RB	_	34	advmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	fits	fit	VBZ	VBZ	_	0	root	_	_
4	well	well	RB	RB	_	3	advmod	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	general	general	JJ	JJ	_	8	amod	_	_
8	observation	observation	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	stress-induced	stress-induced	JJ	JJ	_	11	amod	_	_
11	down-regulation	down-regulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	c-jun	c-jun	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	during	during	IN	IN	_	6	case	_	_
6	induction	induction	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	okadaic	okadaic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	5	nsubj	_	_
4	has	have	VBZ	VBZ	_	5	aux	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	okadaic	okadaic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	20	case	_	_
15	type	type	NN	NN	_	20	compound	_	_
16	1	1	CD	CD	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	2A	2a	NN	NN	_	16	conj	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	phosphatases	phosphatase	NNS	NNS	_	13	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	regulation	regulation	NN	NN	_	7	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	c-jun	c-jun	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	during	during	IN	IN	_	30	case	_	_
29	monocytic	monocytic	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	U-937	u-937	NN	NN	_	34	compound	_	_
33	leukemia	leukemia	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	okadaic	okadaic	JJ	JJ	_	7	amod	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	treatment	treatment	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	3	ccomp	_	_
10	with	with	IN	IN	_	11	case	_	_
11	induction	induction	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	differentiated	differentiate	VBN	VBN	_	16	amod	_	_
15	monocyte	monocyte	NN	NN	_	16	compound	_	_
16	phenotype	phenotype	NN	NN	_	11	nmod	_	_
17	characterized	characterize	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	24	case	_	_
19	:	:	:	:	_	24	punct	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	a	a	LS	LS	_	24	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	arrest	arrest	NN	NN	_	17	nmod	_	_
25	;	;	:	:	_	24	punct	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	b	b	LS	LS	_	29	dep	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	increases	increase	NNS	NNS	_	24	conj	_	_
30	in	in	IN	IN	_	35	case	_	_
31	Mac-1	mac-1	NN	NN	_	35	compound	_	_
32	cell	cell	NN	NN	_	35	compound	_	_
33	surface	surface	NN	NN	_	35	compound	_	_
34	antigen	antigen	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	29	nmod	_	_
36	;	;	:	:	_	24	punct	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	c	c	LS	LS	_	40	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	down-regulation	down-regulation	NN	NN	_	24	conj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	c-myc	c-myc	NN	NN	_	43	compound	_	_
43	transcripts	transcript	NNS	NNS	_	40	nmod	_	_
44	;	;	:	:	_	24	punct	_	_
45	and	and	CC	CC	_	24	cc	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	d	d	LS	LS	_	49	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	induction	induction	NN	NN	_	24	conj	_	_
50	of	of	IN	IN	_	55	case	_	_
51	tumor	tumor	NN	NN	_	55	compound	_	_
52	necrosis	necrosis	NN	NN	_	55	compound	_	_
53	factor	factor	NN	NN	_	55	compound	_	_
54	gene	gene	NN	NN	_	55	compound	_	_
55	expression	expression	NN	NN	_	49	nmod	_	_
56	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	monocytic	monocytic	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	transient	transient	JJ	JJ	_	10	amod	_	_
10	increases	increase	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	c-jun	c-jun	NN	NN	_	14	compound	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	maximal	maximal	JJ	JJ	_	14	acl:relcl	_	_
19	at	at	IN	IN	_	21	case	_	_
20	6	6	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Run-on	run-on	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	detectable	detectable	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	c-jun	c-jun	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	U-937	u-937	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	this	this	DT	DT	_	15	det	_	_
15	rate	rate	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	increased	increase	VBN	VBN	_	5	conj	_	_
18	approximately	approximately	RB	RB	_	19	advmod	_	_
19	40-fold	40-fold	RB	RB	_	17	advmod	_	_
20	following	follow	VBG	VBG	_	23	case	_	_
21	okadaic	okadaic	JJ	JJ	_	23	amod	_	_
22	acid	acid	NN	NN	_	23	compound	_	_
23	exposure	exposure	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	c-jun	c-jun	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	superinduced	superinduce	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	5	nmod	_	_
8	treated	treat	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	okadaic	okadaic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	cycloheximide	cycloheximide	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	whereas	whereas	IN	IN	_	5	dep	_	_
17	inhibition	inhibition	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	17	nmod	_	_
21	had	have	VBD	VBD	_	5	parataxis	_	_
22	little	little	JJ	JJ	_	27	amod	_	_
23	,	,	,	,	_	25	punct	_	_
24	if	if	IN	IN	_	25	mark	_	_
25	any	any	DT	DT	_	27	dep	_	_
26	,	,	,	,	_	25	punct	_	_
27	effect	effect	NN	NN	_	21	dobj	_	_
28	on	on	IN	IN	_	32	case	_	_
29	okadaic	okadaic	JJ	JJ	_	30	amod	_	_
30	acid-induced	acid-induced	JJ	JJ	_	32	amod	_	_
31	c-jun	c-jun	NN	NN	_	32	compound	_	_
32	transcription	transcription	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	half-life	half-life	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	similar	similar	JJ	JJ	_	0	root	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	45-50	45-50	CD	CD	_	10	nummod	_	_
10	min	min	NN	NN	_	7	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	18	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	untreated	untreated	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	okadaic	okadaic	JJ	JJ	_	17	amod	_	_
17	acid-induced	acid-induced	JJ	JJ	_	14	conj	_	_
18	cells	cell	NNS	NNS	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	treatment	treatment	NN	NN	_	12	nsubjpass	_	_
5	with	with	IN	IN	_	8	case	_	_
6	both	both	DT	DT	_	8	cc:preconj	_	_
7	okadaic	okadaic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	cycloheximide	cycloheximide	NN	NN	_	8	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	stabilization	stabilization	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	t	t	NN	NN	_	18	nsubj	_	_
17	1/2	1/2	CD	CD	_	16	nummod	_	_
18	=	=	JJ	JJ	_	14	dep	_	_
19	90	90	CD	CD	_	20	nummod	_	_
20	min	min	NN	NN	_	18	dobj	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	of	of	IN	IN	_	24	case	_	_
23	c-jun	c-jun	NN	NN	_	24	compound	_	_
24	transcripts	transcript	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	17	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	c-jun	c-jun	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	okadaic	okadaic	JJ	JJ	_	15	amod	_	_
15	acid	acid	NN	NN	_	9	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	controlled	control	VBN	VBN	_	6	ccomp	_	_
18	primarily	primarily	RB	RB	_	17	advmod	_	_
19	by	by	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	mechanism	mechanism	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	17	advcl	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	c-jun	c-jun	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	autoinduced	autoinduce	VBN	VBN	_	5	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Jun/AP-1	jun/ap-1	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	17	punct	_	_
15	we	we	PRP	PRP	_	17	nsubj	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	studied	study	VBD	VBD	_	0	root	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	28	case	_	_
20	c-jun	c-jun	NN	NN	_	28	compound	_	_
21	promoter	promoter	NN	NN	_	28	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	positions	position	NNS	NNS	_	28	appos	_	_
24	-132/+170	-132/+170	CD	CD	_	23	dep	_	_
25	)	)	-RRB-	-RRB-	_	23	punct	_	_
26	-reporter	-reporter	JJ	JJ	_	28	amod	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	constructs	construct	NNS	NNS	_	18	nmod	_	_
29	with	with	IN	IN	_	35	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	without	without	IN	IN	_	29	conj	_	_
32	a	a	DT	DT	_	35	det	_	_
33	mutated	mutate	VBN	VBN	_	35	amod	_	_
34	AP-1	ap-1	NN	NN	_	35	compound	_	_
35	element	element	NN	NN	_	18	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	interleukin	interleukin	NN	NN	_	1	nmod	_	_
7	2	2	CD	CD	_	6	nummod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	interleukin	interleukin	NN	NN	_	10	nsubj	_	_
6	2	2	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-2	il-2	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	acts	act	VBZ	VBZ	_	2	ccomp	_	_
11	on	on	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	enhancing	enhance	VBG	VBG	_	10	advcl	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	transcription	transcription	NN	NN	_	24	compound	_	_
22	factor	factor	NN	NN	_	24	compound	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	18	nmod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	consensus	consensus	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	18	nmod	_	_
29	in	in	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	5'	5'	JJ	JJ	_	34	amod	_	_
32	regulatory	regulatory	JJ	JJ	_	34	amod	_	_
33	enhancer	enhancer	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	IL-2	il-2	NN	NN	_	40	compound	_	_
38	receptor	receptor	NN	NN	_	40	compound	_	_
39	alpha	alpha	NN	NN	_	40	compound	_	_
40	chain	chain	NN	NN	_	34	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	p55	p55	NN	NN	_	34	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	2	punct	_	_

1	Similarly	similarly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-2	il-2	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	line	line	NN	NN	_	13	compound	_	_
13	U	u	NN	NN	_	4	nmod	_	_
14	937	937	CD	CD	_	13	nummod	_	_
15	,	,	,	,	_	13	punct	_	_
16	but	but	CC	CC	_	13	cc	_	_
17	not	not	RB	RB	_	21	neg	_	_
18	in	in	IN	IN	_	21	case	_	_
19	resting	rest	VBG	VBG	_	21	amod	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	T-cells	t-cell	NNS	NNS	_	13	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	detectable	detectable	JJ	JJ	_	0	root	_	_
5	within	within	IN	IN	_	7	case	_	_
6	15	15	CD	CD	_	7	nummod	_	_
7	min	min	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	peaks	peak	VBZ	VBZ	_	4	conj	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	9	nmod	_	_
12	after	after	IN	IN	_	11	case	_	_
13	exposure	exposure	NN	NN	_	11	dep	_	_
14	to	to	TO	TO	_	15	case	_	_
15	IL-2	il-2	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	5	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	followed	follow	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	21	dep	_	_
12	that	that	IN	IN	_	21	dobj	_	_
13	inducibility	inducibility	NN	NN	_	21	nsubjpass	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	IL-2	il-2	NN	NN	_	19	compound	_	_
17	receptor	receptor	NN	NN	_	19	compound	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	chain	chain	NN	NN	_	13	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	10	acl	_	_
22	by	by	IN	IN	_	26	case	_	_
23	enhanced	enhance	VBN	VBN	_	26	amod	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	binding	binding	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	that	that	IN	IN	_	51	dobj	_	_
29	a	a	DT	DT	_	31	det	_	_
30	heterologous	heterologous	JJ	JJ	_	31	amod	_	_
31	promoter	promoter	NN	NN	_	51	nsubjpass	_	_
32	containing	contain	VBG	VBG	_	31	acl	_	_
33	the	the	DT	DT	_	37	det	_	_
34	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
35	B	b	NN	NN	_	37	compound	_	_
36	consensus	consensus	NN	NN	_	37	compound	_	_
37	sequence	sequence	NN	NN	_	32	dobj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	-291	-291	CD	CD	_	37	dep	_	_
40	to	to	TO	TO	_	39	dep	_	_
41	-245	-245	CD	CD	_	39	dep	_	_
42	)	)	-RRB-	-RRB-	_	39	punct	_	_
43	of	of	IN	IN	_	49	case	_	_
44	the	the	DT	DT	_	49	det	_	_
45	IL-2	il-2	NN	NN	_	49	compound	_	_
46	receptor	receptor	NN	NN	_	49	compound	_	_
47	alpha	alpha	NN	NN	_	49	compound	_	_
48	chain	chain	NN	NN	_	49	compound	_	_
49	gene	gene	NN	NN	_	37	nmod	_	_
50	is	be	VBZ	VBZ	_	51	auxpass	_	_
51	activated	activate	VBN	VBN	_	21	conj	_	_
52	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	IL-2	il-2	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	increasing	increase	VBG	VBG	_	6	advcl	_	_
9	transcript	transcript	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	p50	p50	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	coding	code	VBG	VBG	_	14	acl	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	p50	p50	NN	NN	_	19	compound	_	_
19	subunit	subunit	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	6	punct	_	_
27	whereas	whereas	IN	IN	_	6	dep	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	levels	level	NNS	NNS	_	36	nsubj	_	_
30	of	of	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	p65	p65	NN	NN	_	35	compound	_	_
33	NF-kappa	nf-kappa	NN	NN	_	35	compound	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	29	nmod	_	_
36	remained	remain	VBD	VBD	_	6	parataxis	_	_
37	unchanged	unchanged	JJ	JJ	_	36	xcomp	_	_
38	.	.	.	.	_	6	punct	_	_

1	Single	single	JJ	JJ	_	3	amod	_	_
2	point	point	NN	NN	_	3	compound	_	_
3	estimation	estimation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	subjects	subject	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	of	of	IN	IN	_	14	case	_	_
14	children	child	NNS	NNS	_	11	conj	_	_
15	under	under	IN	IN	_	19	case	_	_
16	long	long	JJ	JJ	_	19	amod	_	_
17	term	term	NN	NN	_	19	compound	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	19	compound	_	_
19	treatment	treatment	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	single	single	JJ	JJ	_	4	amod	_	_
3	point	point	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	24	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	GR	gr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
14	based	base	VBN	VBN	_	17	case	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	measurement	measurement	NN	NN	_	4	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	specific	specific	JJ	JJ	_	21	amod	_	_
20	dexamethasone	dexamethasone	NN	NN	_	21	compound	_	_
21	binding	binding	NN	NN	_	17	nmod	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	developed	develop	VBN	VBN	_	0	root	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	compared	compare	VBN	VBN	_	24	conj	_	_
27	with	with	IN	IN	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	common	common	JJ	JJ	_	32	amod	_	_
30	multi-point	multi-point	JJ	JJ	_	32	amod	_	_
31	Scatchard	scatchard	NN	NN	_	32	compound	_	_
32	analysis	analysis	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	assay	assay	NN	NN	_	3	compound	_	_
3	conditions	conditions	NN	NN	_	30	nsubjpass	_	_
4	-	-	:	:	_	3	punct	_	_
5	concentration	concentration	NN	NN	_	3	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	ligand	ligand	NN	NN	_	5	nmod	_	_
9	20	20	CD	CD	_	10	nummod	_	_
10	nmol/l	nmol/l	NN	NN	_	5	dep	_	_
11	,	,	,	,	_	5	punct	_	_
12	incubation	incubation	NN	NN	_	15	compound	_	_
13	time	time	NN	NN	_	15	compound	_	_
14	2	2	CD	CD	_	15	nummod	_	_
15	h	h	NN	NN	_	5	conj	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	the	the	DT	DT	_	22	det	_	_
18	cell	cell	NN	NN	_	22	compound	_	_
19	count	count	NN	NN	_	22	compound	_	_
20	2-6	2-6	CD	CD	_	22	nummod	_	_
21	mil.	mil.	CD	CD	_	22	nummod	_	_
22	cells/tube	cells/tube	NNS	NNS	_	5	conj	_	_
23	in	in	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	assay	assay	NN	NN	_	28	compound	_	_
26	volume	volume	NN	NN	_	28	compound	_	_
27	0.25	0.25	CD	CD	_	28	nummod	_	_
28	ml	ml	NN	NN	_	22	nmod	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	found	find	VBN	VBN	_	0	root	_	_
31	to	to	TO	TO	_	33	mark	_	_
32	be	be	VB	VB	_	33	cop	_	_
33	optimal	optimal	JJ	JJ	_	30	xcomp	_	_
34	.	.	.	.	_	30	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	attempt	attempt	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	undertaken	undertake	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	use	use	VB	VB	_	5	xcomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	harvester	harvester	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	separation	separation	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	13	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	unbound	unbound	JJ	JJ	_	18	amod	_	_
18	ligand	ligand	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Though	though	IN	IN	_	14	mark	_	_
2	specifically	specifically	RB	RB	_	3	advmod	_	_
3	bound	bind	VBN	VBN	_	4	amod	_	_
4	dexamethasone	dexamethasone	NN	NN	_	14	nsubj	_	_
5	measured	measure	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	whole-cell	whole-cell	JJ	JJ	_	8	amod	_	_
8	assay	assay	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	that	that	DT	DT	_	4	conj	_	_
11	using	use	VBG	VBG	_	10	acl	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	harvester	harvester	NN	NN	_	11	dobj	_	_
14	correlated	correlate	VBD	VBD	_	28	advcl	_	_
15	well	well	RB	RB	_	14	advmod	_	_
16	,	,	,	,	_	28	punct	_	_
17	almost	almost	RB	RB	_	20	advmod	_	_
18	by	by	IN	IN	_	20	case	_	_
19	one	one	CD	CD	_	20	nummod	_	_
20	order	order	NN	NN	_	21	nmod	_	_
21	lower	lower	JJR	JJR	_	22	amod	_	_
22	values	value	NNS	NNS	_	28	nsubj	_	_
23	obtained	obtain	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	latter	latter	JJ	JJ	_	27	amod	_	_
27	method	method	NN	NN	_	23	nmod	_	_
28	render	render	VBP	VBP	_	0	root	_	_
29	it	it	PRP	PRP	_	30	nsubj	_	_
30	non-applicable	non-applicable	JJ	JJ	_	28	xcomp	_	_
31	for	for	IN	IN	_	33	case	_	_
32	receptor	receptor	NN	NN	_	33	compound	_	_
33	quantitation	quantitation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	16	nsubj	_	_
3	from	from	IN	IN	_	6	case	_	_
4	9	9	CD	CD	_	6	nummod	_	_
5	healthy	healthy	JJ	JJ	_	6	amod	_	_
6	volunteers	volunteer	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	average	average	JJ	JJ	_	10	amod	_	_
9	GR	gr	NN	NN	_	10	compound	_	_
10	concentration	concentration	NN	NN	_	2	dep	_	_
11	7131	7131	CD	CD	_	14	nummod	_	_
12	+/-	+/-	CC	CC	_	11	cc	_	_
13	1256	1256	CD	CD	_	11	conj	_	_
14	sites/cell	sites/cell	NNS	NNS	_	10	dep	_	_
15	)	)	-RRB-	-RRB-	_	10	punct	_	_
16	correlated	correlate	VBD	VBD	_	0	root	_	_
17	excellently	excellently	RB	RB	_	16	advmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	those	those	DT	DT	_	16	nmod	_	_
20	obtained	obtain	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Scatchard	scatchard	NN	NN	_	24	compound	_	_
24	analysis	analysis	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	single	single	JJ	JJ	_	4	amod	_	_
3	point	point	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	8	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	been	be	VBN	VBN	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	applied	apply	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	determination	determination	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	GH	gh	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	10	10	CD	CD	_	15	nummod	_	_
15	children	child	NNS	NNS	_	12	nmod	_	_
16	treated	treat	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	large	large	JJ	JJ	_	19	amod	_	_
19	doses	dose	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	prednisone	prednisone	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	average	average	JJ	JJ	_	3	amod	_	_
3	values	value	NNS	NNS	_	9	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	healthy	healthy	JJ	JJ	_	6	amod	_	_
6	volunteers	volunteer	NNS	NNS	_	3	nmod	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	differ	differ	VB	VB	_	0	root	_	_
10	significantly	significantly	RB	RB	_	9	advmod	_	_
11	from	from	IN	IN	_	12	case	_	_
12	those	those	DT	DT	_	9	nmod	_	_
13	found	find	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	children	child	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	though	though	RB	RB	_	23	advmod	_	_
19	much	much	RB	RB	_	20	advmod	_	_
20	broader	broader	JJR	JJR	_	21	amod	_	_
21	range	range	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	found	find	VBN	VBN	_	9	ccomp	_	_
24	in	in	IN	IN	_	25	case	_	_
25	patients	patient	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	B	b	NN	NN	_	4	nmod:npmod	_	_
4	cell-derived	cell-derived	JJ	JJ	_	5	amod	_	_
5	coactivator	coactivator	NN	NN	_	6	nsubj	_	_
6	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	immunoglobulin	immunoglobulin	NN	NN	_	11	compound	_	_
11	promoters	promoter	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	octamer-binding	octamer-binding	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	B	b	NN	NN	_	4	nmod:npmod	_	_
4	cell-restricted	cell-restricted	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	25	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	required	require	VBN	VBN	_	5	acl	_	_
8	for	for	IN	IN	_	10	case	_	_
9	high	high	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	octamer/Oct-dependent	octamer/oct-dependent	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	nmod	_	_
14	from	from	IN	IN	_	22	case	_	_
15	an	a	DT	DT	_	22	det	_	_
16	immunoglobulin	immunoglobulin	NN	NN	_	18	compound	_	_
17	heavy	heavy	JJ	JJ	_	18	amod	_	_
18	chain	chain	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IgH	igh	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	promoter	promoter	NN	NN	_	10	nmod	_	_
23	,	,	,	,	_	5	punct	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	detected	detect	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	30	case	_	_
27	an	a	DT	DT	_	30	det	_	_
28	in	in	FW	FW	_	30	amod	_	_
29	vitro	vitro	FW	FW	_	28	dep	_	_
30	system	system	NN	NN	_	25	nmod	_	_
31	consisting	consist	VBG	VBG	_	30	acl	_	_
32	of	of	IN	IN	_	35	case	_	_
33	HeLa	hela	NN	NN	_	34	nmod:npmod	_	_
34	cell-derived	cell-derived	JJ	JJ	_	35	amod	_	_
35	extracts	extract	NNS	NNS	_	31	nmod	_	_
36	complemented	complement	VBN	VBN	_	35	acl	_	_
37	with	with	IN	IN	_	42	case	_	_
38	fractionated	fractionate	VBN	VBN	_	42	amod	_	_
39	B	b	NN	NN	_	42	compound	_	_
40	cell	cell	NN	NN	_	42	compound	_	_
41	nuclear	nuclear	JJ	JJ	_	42	amod	_	_
42	proteins	protein	NNS	NNS	_	36	nmod	_	_
43	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	8	nsubjpass	_	_
3	responsible	responsible	JJ	JJ	_	2	amod	_	_
4	for	for	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	designated	designate	VBN	VBN	_	0	root	_	_
9	Oct	oct	NN	NN	_	10	compound	_	_
10	coactivator	coactivator	NN	NN	_	8	xcomp	_	_
11	from	from	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	OCA-B	oca-b	NN	NN	_	10	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	8	punct	_	_

1	OCA-B	oca-b	NN	NN	_	2	nsubj	_	_
2	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	transcription	transcription	NN	NN	_	2	dobj	_	_
5	from	from	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	IgH	igh	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	conjunction	conjunction	NN	NN	_	13	dep	_	_
11	with	with	IN	IN	_	13	case	_	_
12	either	either	CC	CC	_	13	cc:preconj	_	_
13	Oct-1	oct-1	NN	NN	_	2	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	Oct-2	oct-2	NN	NN	_	13	conj	_	_
16	but	but	CC	CC	_	2	cc	_	_
17	shows	show	VBZ	VBZ	_	2	conj	_	_
18	no	no	DT	DT	_	20	neg	_	_
19	significant	significant	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	17	dobj	_	_
21	on	on	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	octamer/Oct-dependent	octamer/oct-dependent	JJ	JJ	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	ubiquitously	ubiquitously	RB	RB	_	28	advmod	_	_
28	expressed	express	VBN	VBN	_	31	amod	_	_
29	histone	histone	NN	NN	_	31	compound	_	_
30	H2B	h2b	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	24	nmod	_	_
32	and	and	CC	CC	_	24	cc	_	_
33	the	the	DT	DT	_	34	det	_	_
34	transcription	transcription	NN	NN	_	24	conj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	USF-	usf-	NN	NN	_	39	amod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	Sp1-regulated	sp1-regulated	JJ	JJ	_	36	conj	_	_
39	promoters	promoter	NNS	NNS	_	34	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	OCA-B	oca-b	NN	NN	_	17	nsubj	_	_
9	is	be	VBZ	VBZ	_	17	cop	_	_
10	a	a	DT	DT	_	17	det	_	_
11	tissue-	tissue-	NN	NN	_	17	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	promoter-	promoter-	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	factor-specific	factor-specific	JJ	JJ	_	11	conj	_	_
17	coactivator	coactivator	NN	NN	_	6	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	OCA-B	oca-b	NN	NN	_	25	nsubj	_	_
21	may	may	MD	MD	_	25	aux	_	_
22	be	be	VB	VB	_	25	cop	_	_
23	a	a	DT	DT	_	25	det	_	_
24	major	major	JJ	JJ	_	25	amod	_	_
25	determinant	determinant	NN	NN	_	17	conj	_	_
26	for	for	IN	IN	_	29	case	_	_
27	B	b	NN	NN	_	28	nmod:npmod	_	_
28	cell-specific	cell-specific	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	32	compound	_	_
32	promoters	promoter	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	light	light	NN	NN	_	5	dep	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	evidence	evidence	NN	NN	_	18	nmod	_	_
6	showing	show	VBG	VBG	_	5	acl	_	_
7	physical	physical	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	functional	functional	JJ	JJ	_	7	conj	_	_
10	interactions	interaction	NNS	NNS	_	6	dobj	_	_
11	between	between	IN	IN	_	13	case	_	_
12	Oct	oct	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	OCA-B	oca-b	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	propose	propose	VBP	VBP	_	0	root	_	_
19	a	a	DT	DT	_	20	det	_	_
20	mechanism	mechanism	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	action	action	NN	NN	_	20	nmod	_	_
23	for	for	IN	IN	_	24	case	_	_
24	OCA-B	oca-b	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	discuss	discuss	VBP	VBP	_	18	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	implications	implication	NNS	NNS	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	OCA-B	oca-b	NN	NN	_	28	nmod	_	_
31	for	for	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	transcriptional	transcriptional	JJ	JJ	_	34	amod	_	_
34	regulation	regulation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	other	other	JJ	JJ	_	38	amod	_	_
37	tissue-specific	tissue-specific	JJ	JJ	_	38	amod	_	_
38	promoters	promoter	NNS	NNS	_	34	nmod	_	_
39	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	human	human	JJ	JJ	_	11	amod	_	_
6	tumor	tumor	NN	NN	_	11	compound	_	_
7	necrosis	necrosis	NN	NN	_	11	compound	_	_
8	factor	factor	NN	NN	_	11	compound	_	_
9	alpha	alpha	NN	NN	_	11	compound	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	21	case	_	_
13	macrophage	macrophage	NN	NN	_	21	compound	_	_
14	,	,	,	,	_	13	punct	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cell	cell	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	13	conj	_	_
21	lines	line	NNS	NNS	_	2	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	13	det	_	_
2	1311-base	1311-base	JJ	JJ	_	3	dep	_	_
3	pair	pair	NN	NN	_	13	amod	_	_
4	human	human	JJ	JJ	_	13	amod	_	_
5	tumor	tumor	NN	NN	_	13	compound	_	_
6	necrosis	necrosis	NN	NN	_	13	compound	_	_
7	factor	factor	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	TNF	tnf	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	alpha	alpha	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	fused	fuse	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	luciferase	luciferase	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Luc	luc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	15	nmod	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	studied	study	VBN	VBN	_	15	conj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	transient	transient	JJ	JJ	_	30	amod	_	_
29	transfection	transfection	NN	NN	_	30	compound	_	_
30	system	system	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	36	case	_	_
32	three	three	CD	CD	_	36	nummod	_	_
33	TNF	tnf	NN	NN	_	36	compound	_	_
34	producing	producing	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	25	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	the	the	DT	DT	_	42	det	_	_
39	U937	u937	NN	NN	_	42	compound	_	_
40	macrophage	macrophage	NN	NN	_	42	compound	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	line	line	NN	NN	_	36	appos	_	_
43	,	,	,	,	_	42	punct	_	_
44	the	the	DT	DT	_	49	det	_	_
45	MLA	mla	NN	NN	_	49	compound	_	_
46	144	144	CD	CD	_	49	nummod	_	_
47	T	t	NN	NN	_	49	compound	_	_
48	cell	cell	NN	NN	_	49	compound	_	_
49	line	line	NN	NN	_	42	conj	_	_
50	,	,	,	,	_	42	punct	_	_
51	and	and	CC	CC	_	42	cc	_	_
52	the	the	DT	DT	_	56	det	_	_
53	729-6	729-6	CD	CD	_	56	nummod	_	_
54	B	b	NN	NN	_	56	compound	_	_
55	cell	cell	NN	NN	_	56	compound	_	_
56	line	line	NN	NN	_	42	conj	_	_
57	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	full	full	JJ	JJ	_	5	amod	_	_
3	length	length	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	construct	construct	NN	NN	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	phorbol	phorbol	NN	NN	_	12	compound	_	_
11	13-myristate	13-myristate	NN	NN	_	12	compound	_	_
12	acetate	acetate	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PMA	pma	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	in	in	IN	IN	_	17	case	_	_
17	each	each	DT	DT	_	8	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	these	these	DT	DT	_	21	det	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	types	type	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Analysis	analysis	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	series	series	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	5'-truncations	5'-truncation	NNS	NNS	_	4	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	several	several	JJ	JJ	_	9	amod	_	_
9	peaks	peak	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	basal	basal	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	PMA	pma	NN	NN	_	14	nmod:npmod	_	_
14	induced	induced	JJ	JJ	_	11	conj	_	_
15	activity	activity	NN	NN	_	9	nmod	_	_
16	suggesting	suggest	VBG	VBG	_	9	acl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	presence	presence	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	25	case	_	_
20	several	several	JJ	JJ	_	25	amod	_	_
21	positive	positive	JJ	JJ	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	negative	negative	JJ	JJ	_	21	conj	_	_
24	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
25	elements	element	NNS	NNS	_	18	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	PMA	pma	NN	NN	_	4	compound	_	_
3	responsive	responsive	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	region	region	NN	NN	_	6	nmod	_	_
10	between	between	IN	IN	_	14	case	_	_
11	-95	-95	CD	CD	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	-36	-36	CD	CD	_	11	conj	_	_
14	bp	bp	NN	NN	_	9	nmod	_	_
15	relative	relative	JJ	JJ	_	9	amod	_	_
16	to	to	TO	TO	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	start	start	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	single	single	JJ	JJ	_	10	amod	_	_
6	AP-2-	ap-2-	NN	NN	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1-like	ap-1-like	JJ	JJ	_	6	conj	_	_
9	consensus	consensus	NN	NN	_	10	compound	_	_
10	sequences	sequence	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	noted	note	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	5	det	_	_
2	AP-2	ap-2	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	AP-1	ap-1	NN	NN	_	2	conj	_	_
5	sites	site	NNS	NNS	_	8	nsubjpass	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	each	each	DT	DT	_	8	dep	_	_
8	modified	modify	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	double	double	JJ	JJ	_	13	amod	_	_
12	point	point	NN	NN	_	13	compound	_	_
13	mutation	mutation	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	modest	modest	JJ	JJ	_	7	amod	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	20-50	20-50	CD	CD	_	5	nummod	_	_
5	%	%	NN	NN	_	2	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	reduction	reduction	NN	NN	_	13	nsubjpass	_	_
8	in	in	IN	IN	_	11	case	_	_
9	TNF	tnf	NN	NN	_	11	compound	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	AP-2	ap-2	NN	NN	_	18	compound	_	_
17	site	site	NN	NN	_	18	compound	_	_
18	mutation	mutation	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	mutation	mutation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	AP-1	ap-1	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	3	nmod	_	_
8	markedly	markedly	RB	RB	_	9	advmod	_	_
9	diminished	diminish	VBD	VBD	_	0	root	_	_
10	both	both	CC	CC	_	16	dep	_	_
11	the	the	DT	DT	_	16	det	_	_
12	basal	basal	JJ	JJ	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	PMA-activated	pma-activated	JJ	JJ	_	12	conj	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	9	dobj	_	_
17	.	.	.	.	_	9	punct	_	_

1	Also	also	RB	RB	_	13	advmod	_	_
2	co-transfections	co-transfection	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	wild-type	wild-type	JJ	JJ	_	7	amod	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	construct	construct	NN	NN	_	2	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	AP-1/c-jun	ap-1/c-jun	NN	NN	_	12	compound	_	_
11	expression	expression	NN	NN	_	12	compound	_	_
12	vector	vector	NN	NN	_	2	nmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	20	case	_	_
15	augmented	augmented	JJ	JJ	_	20	amod	_	_
16	basal	basal	JJ	JJ	_	20	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	PMA-induced	pma-induced	JJ	JJ	_	16	conj	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Redox	redox	NN	NN	_	2	compound	_	_
2	status	status	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	cells	cell	NNS	NNS	_	2	nmod	_	_
5	influences	influence	VBZ	VBZ	_	0	root	_	_
6	constitutive	constitutive	JJ	JJ	_	11	amod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	induced	induce	VBN	VBN	_	6	conj	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	translocation	translocation	NN	NN	_	5	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	HIV	hiv	NN	NN	_	17	compound	_	_
14	long	long	JJ	JJ	_	17	amod	_	_
15	terminal	terminal	JJ	JJ	_	17	amod	_	_
16	repeat	repeat	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	11	conj	_	_
18	in	in	IN	IN	_	24	case	_	_
19	human	human	JJ	JJ	_	24	amod	_	_
20	T	t	NN	NN	_	24	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	monocytic	monocytic	JJ	JJ	_	20	conj	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	11	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	tested	test	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	27	mark	_	_
7	cellular	cellular	JJ	JJ	_	9	amod	_	_
8	activation	activation	NN	NN	_	9	compound	_	_
9	events	event	NNS	NNS	_	27	nsubj	_	_
10	occurring	occur	VBG	VBG	_	9	dep	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	monocytes	monocyte	NNS	NNS	_	13	conj	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	mediated	mediate	VBN	VBN	_	10	conj	_	_
18	through	through	IN	IN	_	19	case	_	_
19	translocation	translocation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	transcription	transcription	NN	NN	_	25	compound	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	19	nmod	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	dependent	dependent	JJ	JJ	_	5	ccomp	_	_
28	upon	upon	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	constitutive	constitutive	JJ	JJ	_	32	amod	_	_
31	redox	redox	NN	NN	_	32	compound	_	_
32	status	status	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	phenolic	phenolic	JJ	JJ	_	8	amod	_	_
4	,	,	,	,	_	3	punct	_	_
5	lipid-soluble	lipid-soluble	JJ	JJ	_	3	dep	_	_
6	,	,	,	,	_	3	punct	_	_
7	chain-breaking	chain-breaking	JJ	JJ	_	3	dep	_	_
8	antioxidants	antioxidant	NNS	NNS	_	2	dobj	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	butylated	butylate	VBN	VBN	_	11	amod	_	_
11	hydroxyanisole	hydroxyanisole	NN	NN	_	8	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	BHA	bha	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	nordihydroquairetic	nordihydroquairetic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	or	or	CC	CC	_	11	cc	_	_
20	alpha-tocopherol	alpha-tocopherol	NN	NN	_	11	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	vitamin	vitamin	NN	NN	_	23	compound	_	_
23	E	e	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	show	show	VB	VB	_	2	advcl	_	_
27	that	that	IN	IN	_	38	mark	_	_
28	peroxyl	peroxyl	JJ	JJ	_	30	amod	_	_
29	radical	radical	JJ	JJ	_	30	amod	_	_
30	scavenging	scavenging	NN	NN	_	38	nsubj	_	_
31	in	in	IN	IN	_	37	case	_	_
32	unstimulated	unstimulated	JJ	JJ	_	37	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	PMA-	pma-	NN	NN	_	32	conj	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	TNF-stimulated	tnf-stimulated	JJ	JJ	_	34	conj	_	_
37	cells	cell	NNS	NNS	_	30	nmod	_	_
38	blocks	block	VBZ	VBZ	_	26	ccomp	_	_
39	the	the	DT	DT	_	40	det	_	_
40	functions	function	NNS	NNS	_	38	dobj	_	_
41	depending	depend	VBG	VBG	_	45	case	_	_
42	on	on	IN	IN	_	45	case	_	_
43	NF-kappa	nf-kappa	NN	NN	_	45	compound	_	_
44	B	b	NN	NN	_	45	compound	_	_
45	activation	activation	NN	NN	_	38	advcl	_	_
46	.	.	.	.	_	2	punct	_	_

1	BHA	bha	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	suppress	suppress	VB	VB	_	3	xcomp	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	only	only	RB	RB	_	8	cc:preconj	_	_
8	PMA-	pma-	NN	NN	_	17	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	TNF-induced	tnf-induced	JJ	JJ	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	but	but	CC	CC	_	8	cc	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	constitutive	constitutive	JJ	JJ	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	HIV-enhancer	hiv-enhancer	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	5	dobj	_	_
18	concomitant	concomitant	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	inhibition	inhibition	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	21	nmod	_	_
27	in	in	IN	IN	_	40	case	_	_
28	both	both	CC	CC	_	30	cc:preconj	_	_
29	lymphoblastoid	lymphoblastoid	JJ	JJ	_	30	dep	_	_
30	T	t	NN	NN	_	40	amod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	J.Jhan	j.jhan	NN	NN	_	30	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	monocytic	monocytic	JJ	JJ	_	30	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	U937	u937	NN	NN	_	35	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	lines	line	NNS	NNS	_	26	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	was	be	VBD	VBD	_	4	cop	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	true	true	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	12	case	_	_
6	KBF	kbf	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	p50	p50	NN	NN	_	9	compound	_	_
9	homodimer	homodimer	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	4	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Secretion	secretion	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TNF	tnf	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	product	product	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	11	case	_	_
8	another	another	DT	DT	_	11	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	nmod:npmod	_	_
10	B-dependent	b-dependent	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	abolished	abolish	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	BHA	bha	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	PMA-stimulated	pma-stimulated	JJ	JJ	_	20	amod	_	_
19	U937	u937	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	anti-oxidative	anti-oxidative	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	BHA	bha	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	accompanied	accompany	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	18	case	_	_
12	thiol	thiol	NN	NN	_	18	compound	_	_
13	,	,	,	,	_	12	punct	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	12	cc	_	_
16	glutathione	glutathione	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	content	content	NN	NN	_	10	nmod	_	_
19	in	in	IN	IN	_	24	case	_	_
20	stimulated	stimulate	VBN	VBN	_	24	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	unstimulated	unstimulated	JJ	JJ	_	20	conj	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cell	cell	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	7	punct	_	_
26	whereas	whereas	IN	IN	_	7	dep	_	_
27	TNF	tnf	NN	NN	_	28	compound	_	_
28	stimulation	stimulation	NN	NN	_	31	nsubj	_	_
29	itself	itself	PRP	PRP	_	28	nmod:npmod	_	_
30	barely	barely	RB	RB	_	31	advmod	_	_
31	modified	modify	VBD	VBD	_	7	parataxis	_	_
32	the	the	DT	DT	_	35	det	_	_
33	cellular	cellular	JJ	JJ	_	35	amod	_	_
34	thiol	thiol	NN	NN	_	35	compound	_	_
35	level	level	NN	NN	_	31	dobj	_	_
36	.	.	.	.	_	7	punct	_	_

1	Oxidative	oxidative	JJ	JJ	_	2	amod	_	_
2	stress	stress	NN	NN	_	22	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	addition	addition	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	H2O2	h2o2	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	culture	culture	NN	NN	_	12	compound	_	_
12	medium	medium	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	J.Jhan	j.jhan	NN	NN	_	17	compound	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	U937	u937	NN	NN	_	14	conj	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	could	could	MD	MD	_	22	aux	_	_
19	not	not	RB	RB	_	22	neg	_	_
20	by	by	IN	IN	_	21	case	_	_
21	itself	itself	PRP	PRP	_	22	nmod	_	_
22	induce	induce	VB	VB	_	0	root	_	_
23	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	TNF	tnf	NN	NN	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	PMA	pma	NN	NN	_	5	conj	_	_
8	do	do	VBP	VBP	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	lead	lead	VB	VB	_	3	ccomp	_	_
11	to	to	TO	TO	_	14	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	10	nmod	_	_
15	through	through	IN	IN	_	16	case	_	_
16	induction	induction	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	changes	change	NNS	NNS	_	16	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	redox	redox	NN	NN	_	23	compound	_	_
23	status	status	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Rather	rather	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	TNF	tnf	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	PMA	pma	NN	NN	_	3	conj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	exert	exert	VB	VB	_	0	root	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	only	only	RB	RB	_	18	advmod	_	_
11	if	if	IN	IN	_	18	mark	_	_
12	cells	cell	NNS	NNS	_	18	nsubj	_	_
13	are	be	VBP	VBP	_	18	cop	_	_
14	in	in	IN	IN	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	appropriate	appropriate	JJ	JJ	_	18	amod	_	_
17	redox	redox	NN	NN	_	18	compound	_	_
18	status	status	NN	NN	_	7	advcl	_	_
19	,	,	,	,	_	18	punct	_	_
20	because	because	IN	IN	_	28	mark	_	_
21	prior	prior	JJ	JJ	_	22	amod	_	_
22	modification	modification	NN	NN	_	28	nsubj	_	_
23	toward	toward	IN	IN	_	24	case	_	_
24	reduction	reduction	NN	NN	_	22	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	BHA	bha	NN	NN	_	27	compound	_	_
27	treatment	treatment	NN	NN	_	22	nmod	_	_
28	prevents	prevent	VBZ	VBZ	_	18	advcl	_	_
29	this	this	DT	DT	_	30	dep	_	_
30	activation	activation	NN	NN	_	28	dep	_	_
31	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	a	a	DT	DT	_	7	det	_	_
5	basal	basal	JJ	JJ	_	7	amod	_	_
6	redox	redox	NN	NN	_	7	compound	_	_
7	equilibrium	equilibrium	NN	NN	_	13	nsubj	_	_
8	tending	tend	VBG	VBG	_	7	acl	_	_
9	toward	toward	IN	IN	_	10	case	_	_
10	oxidation	oxidation	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	a	a	DT	DT	_	13	det	_	_
13	prerequisite	prerequisite	NN	NN	_	2	ccomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	full	full	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transduction	transduction	NN	NN	_	19	compound	_	_
19	pathways	pathway	NNS	NNS	_	16	nmod	_	_
20	regulating	regulate	VBG	VBG	_	16	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	nmod:npmod	_	_
25	B-dependent	b-dependent	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-fos	c-fos	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	c-jun	c-jun	NN	NN	_	3	conj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	jun	jun	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	3	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
13	from	from	IN	IN	_	17	case	_	_
14	young	young	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	elderly	elderly	JJ	JJ	_	14	conj	_	_
17	adults	adult	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	c-fos	c-fos	NN	NN	_	10	compound	_	_
5	,	,	,	,	_	4	punct	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	jun	jun	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	conj	_	_
10	proto-oncogenes	proto-oncogene	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	studied	study	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	21	case	_	_
14	phytohemagglutinin	phytohemagglutinin	NN	NN	_	18	dep	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PHA	pha	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	activated	activate	VBN	VBN	_	21	amod	_	_
19	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PBL	pbl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	from	from	IN	IN	_	29	case	_	_
26	young	young	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	aged	aged	JJ	JJ	_	26	conj	_	_
29	humans	human	NNS	NNS	_	21	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	mRNAs	mrna	NNS	NNS	_	8	nsubj	_	_
3	for	for	IN	IN	_	4	case	_	_
4	c-fos	c-fos	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	detectable	detectable	JJ	JJ	_	0	root	_	_
9	within	within	IN	IN	_	11	case	_	_
10	30	30	CD	CD	_	11	nummod	_	_
11	min	min	NN	NN	_	8	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	reached	reach	VBD	VBD	_	8	conj	_	_
17	maximal	maximal	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	16	dobj	_	_
19	within	within	IN	IN	_	21	case	_	_
20	2	2	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	c-fos	c-fos	NN	NN	_	6	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	jun	jun	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	conj	_	_
6	mRNAs	mrna	NNS	NNS	_	7	nsubj	_	_
7	decreased	decrease	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	pre-activation	pre-activation	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	within	within	IN	IN	_	13	case	_	_
12	6	6	CD	CD	_	13	nummod	_	_
13	h	h	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	while	while	IN	IN	_	18	mark	_	_
16	c-jun	c-jun	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	18	nsubj	_	_
18	remained	remain	VBD	VBD	_	7	advcl	_	_
19	elevated	elevated	JJ	JJ	_	18	xcomp	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	PHA-activated	pha-activated	JJ	JJ	_	3	amod	_	_
3	PBL	pbl	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	no	no	DT	DT	_	7	neg	_	_
6	age-related	age-related	JJ	JJ	_	7	amod	_	_
7	differences	difference	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	16	case	_	_
11	c-fos	c-fos	NN	NN	_	16	compound	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	jun	jun	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	conj	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	c-jun	c-jun	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	6	nsubj	_	_
6	decreased	decrease	VBD	VBD	_	0	root	_	_
7	significantly	significantly	RB	RB	_	6	advmod	_	_
8	(	(	-LRB-	-LRB-	_	20	punct	_	_
9	1.73	1.73	CD	CD	_	20	dep	_	_
10	+/-	+/-	CC	CC	_	9	cc	_	_
11	0.08	0.08	CD	CD	_	9	conj	_	_
12	vs.	vs.	CC	CC	_	9	cc	_	_
13	1.16	1.16	CD	CD	_	9	conj	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	0.09	0.09	CD	CD	_	13	conj	_	_
16	arbitrary	arbitrary	JJ	JJ	_	17	amod	_	_
17	units	unit	NNS	NNS	_	9	dep	_	_
18	,	,	,	,	_	20	punct	_	_
19	P	p	NN	NN	_	20	nsubj	_	_
20	&lt;	&lt;	VBG	VBG	_	7	dep	_	_
21	0.01	0.01	CD	CD	_	20	dobj	_	_
22	,	,	,	,	_	20	punct	_	_
23	young	young	JJ	JJ	_	20	dep	_	_
24	vs.	vs.	CC	CC	_	23	cc	_	_
25	old	old	JJ	JJ	_	23	conj	_	_
26	)	)	-RRB-	-RRB-	_	20	punct	_	_
27	in	in	IN	IN	_	28	case	_	_
28	PBL	pbl	NN	NN	_	6	nmod	_	_
29	from	from	IN	IN	_	31	case	_	_
30	elderly	elderly	JJ	JJ	_	31	amod	_	_
31	individuals	individual	NNS	NNS	_	28	nmod	_	_
32	activated	activate	VBN	VBN	_	28	dep	_	_
33	with	with	IN	IN	_	34	case	_	_
34	PHA	pha	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	5	nsubj	_	_
4	has	have	VBZ	VBZ	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	32	advcl	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	13	nsubj	_	_
9	from	from	IN	IN	_	11	case	_	_
10	elderly	elderly	JJ	JJ	_	11	amod	_	_
11	individuals	individual	NNS	NNS	_	8	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	display	display	VB	VB	_	5	ccomp	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	proliferative	proliferative	JJ	JJ	_	16	amod	_	_
16	responses	response	NNS	NNS	_	13	dobj	_	_
17	when	when	WRB	WRB	_	18	advmod	_	_
18	activated	activate	VBN	VBN	_	13	advcl	_	_
19	via	via	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	anti-CD2	anti-cd2	JJ	JJ	_	22	amod	_	_
22	pathway	pathway	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	32	punct	_	_
24	c-jun	c-jun	NN	NN	_	29	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	jun	jun	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	conj	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	32	nsubjpass	_	_
30	was	be	VBD	VBD	_	32	auxpass	_	_
31	also	also	RB	RB	_	32	advmod	_	_
32	studied	study	VBN	VBN	_	0	root	_	_
33	in	in	IN	IN	_	37	case	_	_
34	anti-CD2-activated	anti-cd2-activated	JJ	JJ	_	37	amod	_	_
35	purified	purify	VBN	VBN	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	32	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	age-related	age-related	JJ	JJ	_	3	amod	_	_
3	differences	difference	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	either	either	DT	DT	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	these	these	DT	DT	_	14	det	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	proto-oncogenes	proto-oncogene	NNS	NNS	_	10	nmod	_	_
15	by	by	IN	IN	_	19	case	_	_
16	anti-CD2	anti-cd2	NN	NN	_	19	compound	_	_
17	activated	activated	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	8	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	decreased	decrease	VBN	VBN	_	8	amod	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	21	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	proliferative	proliferative	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	8	conj	_	_
12	displayed	display	VBN	VBN	_	8	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	PHA-activated	pha-activated	JJ	JJ	_	15	amod	_	_
15	PBL	pbl	NN	NN	_	12	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	elderly	elderly	JJ	JJ	_	18	amod	_	_
18	adults	adult	NNS	NNS	_	15	nmod	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	related	related	JJ	JJ	_	3	ccomp	_	_
22	to	to	TO	TO	_	24	case	_	_
23	age-related	age-related	JJ	JJ	_	24	amod	_	_
24	changes	change	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	c-jun	c-jun	NN	NN	_	28	compound	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	ratio	ratio	NN	NN	_	28	conj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	c-fos	c-fos	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	36	case	_	_
36	c-jun	c-jun	NN	NN	_	32	nmod	_	_
37	mRNA	mrna	NN	NN	_	36	dep	_	_
38	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	novel	novel	JJ	JJ	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	1	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	site	site	NN	NN	_	9	nmod	_	_
13	related	related	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	19	case	_	_
15	steroid/thyroid	steroid/thyroid	JJ	JJ	_	19	compound	_	_
16	hormone	hormone	NN	NN	_	19	compound	_	_
17	receptor	receptor	NN	NN	_	19	compound	_	_
18	response	response	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	13	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	negative	negative	JJ	JJ	_	24	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	sequence	sequence	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	32	case	_	_
26	the	the	DT	DT	_	32	det	_	_
27	human	human	JJ	JJ	_	32	amod	_	_
28	immunodeficiency	immunodeficiency	NN	NN	_	32	compound	_	_
29	virus	virus	NN	NN	_	32	compound	_	_
30	long	long	JJ	JJ	_	32	amod	_	_
31	terminal	terminal	JJ	JJ	_	32	amod	_	_
32	repeat	repeat	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	dobj	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	binds	bind	VBZ	VBZ	_	8	acl:relcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	site	site	NN	NN	_	10	nmod	_	_
14	within	within	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	LTR	ltr	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	type	type	NN	NN	_	16	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	HIV-1	hiv-1	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	10	cc	_	_
28	exerts	exert	VBZ	VBZ	_	10	conj	_	_
29	an	a	DT	DT	_	31	det	_	_
30	inhibitory	inhibitory	JJ	JJ	_	31	amod	_	_
31	effect	effect	NN	NN	_	28	dobj	_	_
32	on	on	IN	IN	_	35	case	_	_
33	virus	virus	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	palindromic	palindromic	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	13	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	site	site	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	recognized	recognize	VBN	VBN	_	3	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	related	related	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	palindromic	palindromic	JJ	JJ	_	18	amod	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	members	member	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	steroid/thyroid	steroid/thyroid	JJ	JJ	_	26	compound	_	_
24	hormone	hormone	NN	NN	_	26	compound	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	family	family	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	characterize	characterize	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	dobj	_	_
8	binding	bind	VBG	VBG	_	7	acl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	site	site	NN	NN	_	8	nmod	_	_
12	as	as	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	100	100	CD	CD	_	15	compound	_	_
15	kD	kd	NN	NN	_	16	amod	_	_
16	protein	protein	NN	NN	_	3	nmod	_	_
17	which	which	WDT	WDT	_	20	nsubj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	most	most	RBS	RBS	_	20	advmod	_	_
20	abundant	abundant	JJ	JJ	_	16	acl:relcl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	binds	bind	VBZ	VBZ	_	20	conj	_	_
27	to	to	TO	TO	_	29	case	_	_
28	site	site	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	nmod	_	_
30	as	as	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	200	200	CD	CD	_	33	compound	_	_
33	kD	kd	NN	NN	_	34	amod	_	_
34	complex	complex	NN	NN	_	26	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	distinct	distinct	JJ	JJ	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	members	member	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	steroid/thyroid	steroid/thyroid	JJ	JJ	_	13	compound	_	_
11	hormone	hormone	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	7	nmod	_	_
14	including	include	VBG	VBG	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	COUP	coup	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	7	nmod	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	has	have	VBZ	VBZ	_	17	acl:relcl	_	_
20	a	a	DT	DT	_	25	det	_	_
21	closely	closely	RB	RB	_	22	advmod	_	_
22	related	related	JJ	JJ	_	25	amod	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	specificity	specificity	NN	NN	_	19	dobj	_	_
26	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	antiinflammatory	antiinflammatory	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	corticosteroids	corticosteroid	NNS	NNS	_	6	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	13	nsubj	_	_
13	regulates	regulate	VBZ	VBZ	_	2	dep	_	_
14	leukocyte	leukocyte	NN	NN	_	15	compound	_	_
15	adhesion	adhesion	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	expression	expression	NN	NN	_	15	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	endothelial-leukocyte	endothelial-leukocyte	JJ	JJ	_	24	amod	_	_
23	adhesion	adhesion	NN	NN	_	24	compound	_	_
24	molecule	molecule	NN	NN	_	20	nmod	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	intercellular	intercellular	JJ	JJ	_	29	amod	_	_
28	adhesion	adhesion	NN	NN	_	29	compound	_	_
29	molecule	molecule	NN	NN	_	24	conj	_	_
30	1	1	CD	CD	_	29	nummod	_	_
31	.	.	.	.	_	13	punct	_	_

1	Corticosteroids	corticosteroid	NNS	NNS	_	6	nsubj	_	_
2	are	be	VBP	VBP	_	6	cop	_	_
3	the	the	DT	DT	_	6	det	_	_
4	preeminent	preeminent	JJ	JJ	_	6	amod	_	_
5	antiinflammatory	antiinflammatory	JJ	JJ	_	6	amod	_	_
6	agents	agent	NNS	NNS	_	0	root	_	_
7	although	although	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	18	nsubjpass	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	impart	impart	VBP	VBP	_	10	acl:relcl	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	efficacy	efficacy	NN	NN	_	12	dobj	_	_
15	have	have	VBP	VBP	_	18	aux	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	defined	define	VBN	VBN	_	6	advcl	_	_
19	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	endothelium	endothelium	NN	NN	_	3	nsubj	_	_
3	plays	play	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	critical	critical	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	inflammation	inflammation	NN	NN	_	3	nmod	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	directing	direct	VBG	VBG	_	3	advcl	_	_
11	circulating	circulate	VBG	VBG	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	10	dobj	_	_
13	into	into	IN	IN	_	15	case	_	_
14	extravascular	extravascular	JJ	JJ	_	15	amod	_	_
15	tissues	tissue	NNS	NNS	_	10	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	expressing	express	VBG	VBG	_	10	advcl	_	_
18	adhesive	adhesive	JJ	JJ	_	19	amod	_	_
19	molecules	molecule	NNS	NNS	_	17	dobj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	leukocytes	leukocyte	NNS	NNS	_	19	nmod	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	27	punct	_	_
23	e.g.	e.g.	FW	FW	_	27	dep	_	_
24	,	,	,	,	_	27	punct	_	_
25	endothelial-leukocyte	endothelial-leukocyte	JJ	JJ	_	27	amod	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecule	molecule	NN	NN	_	19	nmod	_	_
28	1	1	CD	CD	_	27	nummod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	ELAM-1	elam-1	NN	NN	_	27	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	intercellular	intercellular	JJ	JJ	_	35	amod	_	_
34	adhesion	adhesion	NN	NN	_	35	compound	_	_
35	molecule	molecule	NN	NN	_	27	conj	_	_
36	1	1	CD	CD	_	35	nummod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	ICAM-1	icam-1	NN	NN	_	35	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	-RSB-	-rsb-	-RRB-	-RRB-	_	27	punct	_	_
41	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	determined	determine	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	6	mark	_	_
5	corticosteroids	corticosteroid	NNS	NNS	_	6	nsubj	_	_
6	suppress	suppress	VBP	VBP	_	3	ccomp	_	_
7	inflammation	inflammation	NN	NN	_	6	dobj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	adhesion	adhesion	NN	NN	_	14	compound	_	_
14	molecules	molecule	NNS	NNS	_	11	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	neutrophils	neutrophil	NNS	NNS	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	polymorphonuclear	polymorphonuclear	JJ	JJ	_	19	amod	_	_
19	leukocytes	leukocyte	NNS	NNS	_	14	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	Preincubation	preincubation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	endothelial	endothelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	endotoxin	endotoxin	NN	NN	_	1	nmod	_	_
7	-LSB-	-lsb-	-LRB-	-LRB-	_	8	punct	_	_
8	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LPS	lps	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	1	1	CD	CD	_	14	nummod	_	_
14	microgram/ml	microgram/ml	NN	NN	_	8	appos	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	8	punct	_	_
16	led	lead	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	4-fold	4-fold	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	subsequent	subsequent	JJ	JJ	_	23	amod	_	_
23	adherence	adherence	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	polymorphonuclear	polymorphonuclear	JJ	JJ	_	26	amod	_	_
26	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	P	p	NN	NN	_	29	nsubj	_	_
29	&lt;	&lt;	VBG	VBG	_	26	dep	_	_
30	0.0001	0.0001	CD	CD	_	29	dobj	_	_
31	,	,	,	,	_	29	punct	_	_
32	n	n	NN	NN	_	33	nsubj	_	_
33	=	=	JJ	JJ	_	29	parataxis	_	_
34	10	10	CD	CD	_	33	dobj	_	_
35	)	)	-RRB-	-RRB-	_	29	punct	_	_
36	to	to	TO	TO	_	38	case	_	_
37	endothelial	endothelial	JJ	JJ	_	38	amod	_	_
38	cells	cell	NNS	NNS	_	23	nmod	_	_
39	,	,	,	,	_	20	punct	_	_
40	an	a	DT	DT	_	41	det	_	_
41	increase	increase	NN	NN	_	20	appos	_	_
42	that	that	WDT	WDT	_	45	nsubjpass	_	_
43	was	be	VBD	VBD	_	45	auxpass	_	_
44	markedly	markedly	RB	RB	_	45	advmod	_	_
45	attenuated	attenuate	VBN	VBN	_	41	acl:relcl	_	_
46	when	when	WRB	WRB	_	50	advmod	_	_
47	endothelial	endothelial	JJ	JJ	_	48	amod	_	_
48	cells	cell	NNS	NNS	_	50	nsubjpass	_	_
49	were	be	VBD	VBD	_	50	auxpass	_	_
50	treated	treat	VBN	VBN	_	45	advcl	_	_
51	with	with	IN	IN	_	52	case	_	_
52	dexamethasone	dexamethasone	NN	NN	_	50	nmod	_	_
53	(	(	-LRB-	-LRB-	_	55	punct	_	_
54	IC50	ic50	NN	NN	_	55	nsubj	_	_
55	&lt;	&lt;	VBG	VBG	_	52	dep	_	_
56	1	1	CD	CD	_	57	nummod	_	_
57	nM	nm	NN	NN	_	55	dobj	_	_
58	,	,	,	,	_	55	punct	_	_
59	P	p	NN	NN	_	60	nsubj	_	_
60	&lt;	&lt;	VBG	VBG	_	55	parataxis	_	_
61	0.0001	0.0001	CD	CD	_	60	dobj	_	_
62	,	,	,	,	_	55	punct	_	_
63	n	n	NN	NN	_	64	nsubj	_	_
64	=	=	VBG	VBG	_	55	parataxis	_	_
65	6	6	CD	CD	_	64	dobj	_	_
66	or	or	CC	CC	_	65	cc	_	_
67	7	7	CD	CD	_	65	conj	_	_
68	)	)	-RRB-	-RRB-	_	55	punct	_	_
69	during	during	IN	IN	_	70	case	_	_
70	preincubation	preincubation	NN	NN	_	50	nmod	_	_
71	with	with	IN	IN	_	72	case	_	_
72	LPS	lps	NN	NN	_	70	nmod	_	_
73	.	.	.	.	_	16	punct	_	_

1	Moreover	moreover	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	steroid	steroid	NN	NN	_	7	compound	_	_
5	receptor	receptor	NN	NN	_	7	compound	_	_
6	agonist	agonist	NN	NN	_	7	compound	_	_
7	cortisol	cortisol	NN	NN	_	24	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	microM	microm	NN	NN	_	7	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	7	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	7	cc	_	_
15	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
16	inactive	inactive	JJ	JJ	_	18	amod	_	_
17	metabolite	metabolite	NN	NN	_	18	compound	_	_
18	tetrahydrocortisol	tetrahydrocortisol	NN	NN	_	7	conj	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	10	10	CD	CD	_	21	nummod	_	_
21	microM	microm	NN	NN	_	18	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	7	punct	_	_
24	diminished	diminish	VBD	VBD	_	0	root	_	_
25	LPS-induced	lps-induced	JJ	JJ	_	28	amod	_	_
26	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	adhesiveness	adhesiveness	NN	NN	_	24	dobj	_	_
29	.	.	.	.	_	24	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	24	nsubjpass	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	action	action	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
10	through	through	IN	IN	_	11	case	_	_
11	ligation	ligation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	corticosteroid	corticosteroid	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	11	nmod	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	14	dep	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	hGRs	hgr	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	provided	provide	VBN	VBN	_	0	root	_	_
25	by	by	IN	IN	_	26	case	_	_
26	experiments	experiment	NNS	NNS	_	24	nmod	_	_
27	utilizing	utilize	VBG	VBG	_	26	acl	_	_
28	the	the	DT	DT	_	31	det	_	_
29	steroid	steroid	NN	NN	_	31	compound	_	_
30	antagonist	antagonist	NN	NN	_	31	compound	_	_
31	RU-486	ru-486	NN	NN	_	27	dobj	_	_
32	.	.	.	.	_	24	punct	_	_

1	RU-486	ru-486	NN	NN	_	28	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	10	10	CD	CD	_	4	nummod	_	_
4	microM	microm	NN	NN	_	1	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	1	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	prevents	prevent	VBZ	VBZ	_	1	acl:relcl	_	_
9	translocation	translocation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	ligated	ligate	VBN	VBN	_	12	amod	_	_
12	hGR	hgr	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	9	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	inhibiting	inhibit	VBG	VBG	_	8	advcl	_	_
18	dissociation	dissociation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	hGR	hgr	NN	NN	_	18	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	heat	heat	NN	NN	_	24	compound	_	_
23	shock	shock	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	18	nmod	_	_
25	90	90	CD	CD	_	24	nummod	_	_
26	,	,	,	,	_	1	punct	_	_
27	completely	completely	RB	RB	_	28	advmod	_	_
28	aborted	abort	VBD	VBD	_	0	root	_	_
29	the	the	DT	DT	_	30	det	_	_
30	effect	effect	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	dexamethasone	dexamethasone	NN	NN	_	30	nmod	_	_
33	on	on	IN	IN	_	34	case	_	_
34	adhesiveness	adhesiveness	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	endothelial	endothelial	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	P	p	NN	NN	_	40	nsubj	_	_
40	&lt;	&lt;	VBG	VBG	_	37	dep	_	_
41	0.0005	0.0005	CD	CD	_	40	dobj	_	_
42	,	,	,	,	_	40	punct	_	_
43	n	n	NN	NN	_	44	nsubj	_	_
44	=	=	JJ	JJ	_	40	parataxis	_	_
45	3	3	CD	CD	_	44	dobj	_	_
46	)	)	-RRB-	-RRB-	_	40	punct	_	_
47	.	.	.	.	_	28	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	endothelial	endothelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	LPS	lps	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	microgram/ml	microgram/ml	NN	NN	_	6	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	stimulated	stimulate	VBD	VBD	_	0	root	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	ELAM-1	elam-1	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	as	as	IN	IN	_	17	mark	_	_
17	shown	show	VBN	VBN	_	11	advcl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	Northern	northern	NN	NN	_	21	compound	_	_
20	blot	blot	NN	NN	_	21	compound	_	_
21	analysis	analysis	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	11	punct	_	_
23	and	and	CC	CC	_	11	cc	_	_
24	expression	expression	NN	NN	_	11	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	membrane-associated	membrane-associated	JJ	JJ	_	27	amod	_	_
27	ELAM-1	elam-1	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	ICAM-1	icam-1	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	24	punct	_	_
31	as	as	IN	IN	_	32	mark	_	_
32	shown	show	VBN	VBN	_	24	advcl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	quantitative	quantitative	JJ	JJ	_	35	amod	_	_
35	immunofluorescence	immunofluorescence	NN	NN	_	32	nmod	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	both	both	DT	DT	_	38	det	_	_
38	P	p	NN	NN	_	39	nsubj	_	_
39	&lt;	&lt;	VBG	VBG	_	35	dep	_	_
40	0.001	0.001	CD	CD	_	39	dobj	_	_
41	,	,	,	,	_	39	punct	_	_
42	n	n	NN	NN	_	43	nsubj	_	_
43	=	=	VBG	VBG	_	39	parataxis	_	_
44	9	9	CD	CD	_	43	dobj	_	_
45	)	)	-RRB-	-RRB-	_	39	punct	_	_
46	.	.	.	.	_	11	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	3	nsubj	_	_
2	markedly	markedly	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	LPS-stimulated	lps-stimulated	JJ	JJ	_	5	amod	_	_
5	accumulation	accumulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	mRNA	mrna	NN	NN	_	5	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	ELAM-1	elam-1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	expression	expression	NN	NN	_	5	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	ELAM-1	elam-1	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ICAM-1	icam-1	NN	NN	_	13	conj	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	IC50	ic50	NN	NN	_	18	nsubj	_	_
18	&lt;	&lt;	VBG	VBG	_	13	dep	_	_
19	10	10	CD	CD	_	20	nummod	_	_
20	nM	nm	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	18	punct	_	_
22	both	both	DT	DT	_	23	det	_	_
23	P	p	NN	NN	_	24	nsubj	_	_
24	&lt;	&lt;	VBG	VBG	_	18	parataxis	_	_
25	0.001	0.001	CD	CD	_	24	dobj	_	_
26	,	,	,	,	_	18	punct	_	_
27	n	n	NN	NN	_	28	nsubj	_	_
28	=	=	VBG	VBG	_	18	parataxis	_	_
29	4-9	4-9	CD	CD	_	28	dobj	_	_
30	)	)	-RRB-	-RRB-	_	18	punct	_	_
31	;	;	:	:	_	3	punct	_	_
32	inhibition	inhibition	NN	NN	_	38	nsubjpass	_	_
33	of	of	IN	IN	_	34	case	_	_
34	expression	expression	NN	NN	_	32	nmod	_	_
35	by	by	IN	IN	_	36	case	_	_
36	dexamethasone	dexamethasone	NN	NN	_	32	nmod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	reversed	reverse	VBN	VBN	_	3	parataxis	_	_
39	by	by	IN	IN	_	40	case	_	_
40	RU-486	ru-486	NN	NN	_	38	nmod	_	_
41	(	(	-LRB-	-LRB-	_	44	punct	_	_
42	both	both	DT	DT	_	43	det	_	_
43	P	p	NN	NN	_	44	nsubj	_	_
44	&lt;	&lt;	VBG	VBG	_	40	dep	_	_
45	0.005	0.005	CD	CD	_	44	dobj	_	_
46	,	,	,	,	_	44	punct	_	_
47	n	n	NN	NN	_	48	nsubj	_	_
48	=	=	VBG	VBG	_	44	parataxis	_	_
49	4-6	4-6	CD	CD	_	48	dobj	_	_
50	)	)	-RRB-	-RRB-	_	44	punct	_	_
51	.	.	.	.	_	38	punct	_	_

1	As	as	IN	IN	_	5	mark	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	adhesion	adhesion	NN	NN	_	5	compound	_	_
5	studies	study	NNS	NNS	_	11	advcl	_	_
6	,	,	,	,	_	11	punct	_	_
7	cortisol	cortisol	NN	NN	_	11	nsubj	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	7	cc	_	_
10	tetrahydrocortisol	tetrahydrocortisol	NN	NN	_	7	conj	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	expression	expression	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	ELAM-1	elam-1	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	ICAM-1	icam-1	NN	NN	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	both	both	DT	DT	_	19	det	_	_
19	P	p	NN	NN	_	20	nsubj	_	_
20	&lt;	&lt;	VBG	VBG	_	14	dep	_	_
21	0.005	0.005	CD	CD	_	20	dobj	_	_
22	,	,	,	,	_	20	punct	_	_
23	n	n	NN	NN	_	24	nsubj	_	_
24	=	=	JJ	JJ	_	20	parataxis	_	_
25	3	3	CD	CD	_	24	dobj	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	4	4	CD	CD	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	20	punct	_	_
29	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	sodium	sodium	NN	NN	_	5	compound	_	_
5	salicylate	salicylate	NN	NN	_	10	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	mM	mm	NN	NN	_	5	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	neither	neither	CC	CC	_	12	cc:preconj	_	_
12	adhesion	adhesion	NN	NN	_	10	dobj	_	_
13	nor	nor	CC	CC	_	12	cc	_	_
14	expression	expression	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	these	these	DT	DT	_	18	det	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecules	molecule	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	antagonism	antagonism	NN	NN	_	14	nsubj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	endotoxin-induced	endotoxin-induced	JJ	JJ	_	10	amod	_	_
10	inflammation	inflammation	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	instance	instance	NN	NN	_	3	ccomp	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	general	general	JJ	JJ	_	19	amod	_	_
18	biological	biological	JJ	JJ	_	19	amod	_	_
19	principle	principle	NN	NN	_	14	nmod	_	_
20	that	that	IN	IN	_	27	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	27	nsubj	_	_
24	is	be	VBZ	VBZ	_	27	cop	_	_
25	a	a	DT	DT	_	27	det	_	_
26	hormone-dependent	hormone-dependent	JJ	JJ	_	27	amod	_	_
27	regulator	regulator	NN	NN	_	19	ccomp	_	_
28	of	of	IN	IN	_	29	case	_	_
29	transcription	transcription	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Membrane	membrane	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	for	for	IN	IN	_	4	case	_	_
4	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	pathway	pathway	NN	NN	_	2	dep	_	_
9	for	for	IN	IN	_	11	case	_	_
10	mineralocorticoid	mineralocorticoid	NN	NN	_	11	compound	_	_
11	action	action	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	Rapid	rapid	JJ	JJ	_	5	amod	_	_
2	nongenomic	nongenomic	JJ	JJ	_	5	amod	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	effects	effect	NNS	NNS	_	20	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	aldosterone	aldosterone	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	electrolytes	electrolyte	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	volume	volume	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	Na(+)-H+	na(+)-h+	JJ	JJ	_	17	amod	_	_
17	antiport	antiport	NN	NN	_	10	conj	_	_
18	have	have	VBP	VBP	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	mononuclear	mononuclear	JJ	JJ	_	24	amod	_	_
24	leukocytes	leukocyte	NNS	NNS	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HML	hml	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	20	punct	_	_

1	Binding	binding	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	125I-labeled	125i-labeled	JJ	JJ	_	4	amod	_	_
4	aldosterone	aldosterone	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	plasma	plasma	NN	NN	_	7	compound	_	_
7	membranes	membrane	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	HML	hml	NN	NN	_	7	nmod	_	_
10	shares	share	VBZ	VBZ	_	0	root	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	features	feature	NNS	NNS	_	10	dobj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	these	these	DT	DT	_	16	det	_	_
15	functional	functional	JJ	JJ	_	16	amod	_	_
16	data	datum	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	includes	include	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	8	det	_	_
4	very	very	RB	RB	_	5	advmod	_	_
5	low	low	JJ	JJ	_	8	amod	_	_
6	apparent	apparent	JJ	JJ	_	8	amod	_	_
7	dissociation	dissociation	NN	NN	_	8	compound	_	_
8	constant	constant	NN	NN	_	2	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Kd	kd	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	of	of	IN	IN	_	14	case	_	_
13	0.1	0.1	CD	CD	_	14	nummod	_	_
14	nM	nm	NN	NN	_	8	nmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	aldosterone	aldosterone	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	17	conj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	Na(+)-H(+)-antiport	na(+)-h(+)-antiport	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	8	punct	_	_
25	a	a	DT	DT	_	28	det	_	_
26	high	high	JJ	JJ	_	28	amod	_	_
27	turnover	turnover	NN	NN	_	28	compound	_	_
28	rate	rate	NN	NN	_	8	conj	_	_
29	,	,	,	,	_	8	punct	_	_
30	and	and	CC	CC	_	8	cc	_	_
31	the	the	DT	DT	_	35	det	_	_
32	almost	almost	RB	RB	_	33	advmod	_	_
33	exclusive	exclusive	JJ	JJ	_	35	amod	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	selectivity	selectivity	NN	NN	_	8	conj	_	_
36	for	for	IN	IN	_	37	case	_	_
37	aldosterone	aldosterone	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	15	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	RU	ru	NN	NN	_	1	conj	_	_
4	26988	26988	CD	CD	_	3	nummod	_	_
5	,	,	,	,	_	1	punct	_	_
6	corticosterone	corticosterone	NN	NN	_	1	conj	_	_
7	,	,	,	,	_	1	punct	_	_
8	ouabain	ouabain	NN	NN	_	1	conj	_	_
9	,	,	,	,	_	1	punct	_	_
10	amiloride	amiloride	NN	NN	_	1	conj	_	_
11	,	,	,	,	_	1	punct	_	_
12	and	and	CC	CC	_	1	cc	_	_
13	18-hydroxyprogesterone	18-hydroxyprogesterone	NN	NN	_	1	conj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	inactive	inactive	JJ	JJ	_	0	root	_	_
16	as	as	IN	IN	_	17	case	_	_
17	ligands	ligand	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	Deoxycorticosterone	deoxycorticosterone	NN	NN	_	2	compound	_	_
2	acetate	acetate	NN	NN	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	intermediate	intermediate	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	apparent	apparent	JJ	JJ	_	10	amod	_	_
10	Kd	kd	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	100	100	CD	CD	_	13	nummod	_	_
13	nM	nm	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	aldosterone	aldosterone	NN	NN	_	9	nmod	_	_
12	being	be	VBG	VBG	_	13	cop	_	_
13	compatible	compatible	JJ	JJ	_	7	dep	_	_
14	with	with	IN	IN	_	16	case	_	_
15	major	major	JJ	JJ	_	16	amod	_	_
16	aspects	aspect	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	nongenomic	nongenomic	JJ	JJ	_	20	amod	_	_
20	effects	effect	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Reticuloendotheliosis	reticuloendotheliosis	NN	NN	_	6	compound	_	_
2	virus	virus	NN	NN	_	6	compound	_	_
3	long	long	JJ	JJ	_	6	amod	_	_
4	terminal	terminal	JJ	JJ	_	6	amod	_	_
5	repeat	repeat	NN	NN	_	6	compound	_	_
6	elements	element	NNS	NNS	_	9	nsubj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	efficient	efficient	JJ	JJ	_	9	amod	_	_
9	promoters	promoter	NNS	NNS	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	various	various	JJ	JJ	_	14	amod	_	_
14	species	species	NNS	NNS	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	tissue	tissue	NN	NN	_	14	conj	_	_
17	origin	origin	NN	NN	_	11	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	including	include	VBG	VBG	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	11	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Promiscuous	promiscuous	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	reticuloendotheliosis	reticuloendotheliosis	NN	NN	_	7	compound	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	REV	rev	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	long	long	JJ	JJ	_	13	amod	_	_
12	terminal	terminal	JJ	JJ	_	13	amod	_	_
13	repeat	repeat	NN	NN	_	7	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	LTR	ltr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	detected	detect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	22	case	_	_
20	transient	transient	JJ	JJ	_	22	amod	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	assays	assay	NNS	NNS	_	18	nmod	_	_
23	using	use	VBG	VBG	_	18	xcomp	_	_
24	LTR-chloramphenicol	ltr-chloramphenicol	NN	NN	_	27	compound	_	_
25	acetyltransferase-encoding	acetyltransferase-encoding	JJ	JJ	_	27	amod	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	chimeras	chimera	NNS	NNS	_	23	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	and	and	CC	CC	_	27	cc	_	_
30	cells	cell	NNS	NNS	_	27	conj	_	_
31	of	of	IN	IN	_	36	case	_	_
32	diverse	diverse	JJ	JJ	_	33	amod	_	_
33	species	species	NNS	NNS	_	36	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	tissue	tissue	NN	NN	_	33	conj	_	_
36	type	type	NN	NN	_	30	nmod	_	_
37	;	;	:	:	_	18	punct	_	_
38	levels	level	NNS	NNS	_	46	nsubj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	expression	expression	NN	NN	_	38	nmod	_	_
41	from	from	IN	IN	_	45	case	_	_
42	two	two	CD	CD	_	45	nummod	_	_
43	different	different	JJ	JJ	_	45	amod	_	_
44	REV	rev	NN	NN	_	45	compound	_	_
45	LTRs	ltr	NNS	NNS	_	40	nmod	_	_
46	correlate	correlate	VBP	VBP	_	18	parataxis	_	_
47	with	with	IN	IN	_	48	case	_	_
48	reports	report	NNS	NNS	_	46	nmod	_	_
49	of	of	IN	IN	_	50	case	_	_
50	pathogenicity	pathogenicity	NN	NN	_	48	nmod	_	_
51	of	of	IN	IN	_	54	case	_	_
52	the	the	DT	DT	_	54	det	_	_
53	respective	respective	JJ	JJ	_	54	amod	_	_
54	viruses	virus	NNS	NNS	_	50	nmod	_	_
55	in	in	FW	FW	_	56	compound	_	_
56	vivo	vivo	FW	FW	_	50	advmod	_	_
57	.	.	.	.	_	46	punct	_	_

1	REVs	rev	NNS	NNS	_	4	nsubj	_	_
2	do	do	VBP	VBP	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	encode	encode	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	transactivator	transactivator	NN	NN	_	4	dobj	_	_
7	targeted	target	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	viral	viral	JJ	JJ	_	11	amod	_	_
11	LTR	ltr	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	cells	cell	NNS	NNS	_	32	nsubj	_	_
15	infected	infect	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	Marek	marek	NN	NN	_	20	nmod:poss	_	_
18	's	's	POS	POS	_	17	case	_	_
19	disease	disease	NN	NN	_	20	compound	_	_
20	virus	virus	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	23	det	_	_
23	herpesvirus	herpesvirus	NN	NN	_	20	appos	_	_
24	with	with	IN	IN	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	overlapping	overlap	VBG	VBG	_	28	amod	_	_
27	host	host	NN	NN	_	28	compound	_	_
28	range	range	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	do	do	VBP	VBP	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	express	express	VB	VB	_	4	conj	_	_
33	factors	factor	NNS	NNS	_	32	dobj	_	_
34	that	that	WDT	WDT	_	36	nsubj	_	_
35	preferentially	preferentially	RB	RB	_	36	advmod	_	_
36	enhance	enhance	VBP	VBP	_	33	acl:relcl	_	_
37	expression	expression	NN	NN	_	36	dobj	_	_
38	from	from	IN	IN	_	39	case	_	_
39	REV	rev	NN	NN	_	37	nmod	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	avian	avian	JJ	JJ	_	44	amod	_	_
42	sarcoma/leukemia	sarcoma/leukemia	NN	NN	_	44	compound	_	_
43	virus	virus	NN	NN	_	44	compound	_	_
44	LTRs	ltr	NNS	NNS	_	39	conj	_	_
45	.	.	.	.	_	4	punct	_	_

1	REV	rev	NN	NN	_	2	compound	_	_
2	LTRs	ltr	NNS	NNS	_	3	nsubj	_	_
3	work	work	VBP	VBP	_	0	root	_	_
4	efficiently	efficiently	RB	RB	_	3	advmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	viable	viable	JJ	JJ	_	13	amod	_	_
13	alternatives	alternative	NNS	NNS	_	3	conj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	promoters	promoter	NNS	NNS	_	13	nmod	_	_
16	commonly	commonly	RB	RB	_	17	advmod	_	_
17	used	use	VBN	VBN	_	15	acl	_	_
18	for	for	IN	IN	_	19	case	_	_
19	expression	expression	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cloned	clone	VBN	VBN	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	They	they	PRP	PRP	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	prove	prove	VB	VB	_	0	root	_	_
5	useful	useful	JJ	JJ	_	4	xcomp	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	identification	identification	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	15	case	_	_
10	new	new	JJ	JJ	_	15	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	ubiquitous	ubiquitous	JJ	JJ	_	10	dep	_	_
13	cellular	cellular	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Natural	natural	JJ	JJ	_	2	amod	_	_
2	variants	variant	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
6	long	long	JJ	JJ	_	8	amod	_	_
7	terminal	terminal	JJ	JJ	_	8	amod	_	_
8	repeat	repeat	NN	NN	_	2	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	analysis	analysis	NN	NN	_	2	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	promoters	promoter	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	duplicated	duplicated	JJ	JJ	_	17	amod	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	motifs	motif	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	variation	variation	NN	NN	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	long	long	JJ	JJ	_	7	amod	_	_
6	terminal	terminal	JJ	JJ	_	7	amod	_	_
7	repeat	repeat	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	LTR	ltr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	region	region	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HIV-1	hiv-1	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	analyzed	analyze	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	isolates	isolate	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	17	17	CD	CD	_	22	nummod	_	_
21	infected	infected	JJ	JJ	_	22	amod	_	_
22	individuals	individual	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	classes	class	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	LTR	ltr	NN	NN	_	6	compound	_	_
5	size	size	NN	NN	_	6	compound	_	_
6	variants	variant	NNS	NNS	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
3	variant	variant	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	containing	contain	VBG	VBG	_	5	xcomp	_	_
7	an	a	DT	DT	_	10	det	_	_
8	additional	additional	JJ	JJ	_	10	amod	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	site	site	NN	NN	_	6	dobj	_	_
11	for	for	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	Sp1	sp1	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Another	another	DT	DT	_	4	det	_	_
2	LTR	ltr	NN	NN	_	4	compound	_	_
3	size	size	NN	NN	_	4	compound	_	_
4	variation	variation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	four	four	CD	CD	_	9	nummod	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	region	region	NN	NN	_	6	nmod	_	_
13	just	just	RB	RB	_	14	advmod	_	_
14	upstream	upstream	JJ	JJ	_	12	amod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	enhancer	enhancer	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	variation	variation	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	result	result	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	duplication	duplication	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	short	short	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CTG-motif	ctg-motif	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	5	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	culture	culture	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	natural	natural	JJ	JJ	_	8	amod	_	_
8	variant	variant	NN	NN	_	13	nsubj	_	_
9	with	with	IN	IN	_	12	case	_	_
10	four	four	CD	CD	_	12	nummod	_	_
11	Sp1	sp1	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	8	nmod	_	_
13	had	have	VBD	VBD	_	4	ccomp	_	_
14	a	a	DT	DT	_	18	det	_	_
15	slightly	slightly	RB	RB	_	16	advmod	_	_
16	higher	higher	JJR	JJR	_	18	amod	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	13	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	viral	viral	JJ	JJ	_	22	amod	_	_
21	replication	replication	NN	NN	_	22	compound	_	_
22	rate	rate	NN	NN	_	18	conj	_	_
23	than	than	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	isogenic	isogenic	JJ	JJ	_	27	amod	_	_
26	control	control	NN	NN	_	27	compound	_	_
27	LTR	ltr	NN	NN	_	18	nmod	_	_
28	with	with	IN	IN	_	31	case	_	_
29	three	three	CD	CD	_	31	nummod	_	_
30	Sp1	sp1	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	positive	positive	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	duplicated	duplicated	JJ	JJ	_	7	amod	_	_
7	CTG-motif	ctg-motif	NN	NN	_	3	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	measure	measure	VB	VB	_	24	advcl	_	_
5	small	small	JJ	JJ	_	6	amod	_	_
6	differences	difference	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	6	nmod	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	accurately	accurately	RB	RB	_	4	advmod	_	_
12	,	,	,	,	_	24	punct	_	_
13	equal	equal	JJ	JJ	_	14	amod	_	_
14	amounts	amount	NNS	NNS	_	24	nsubjpass	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	size	size	NN	NN	_	18	compound	_	_
18	variant	variant	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	wild-type	wild-type	JJ	JJ	_	22	amod	_	_
22	plasmid	plasmid	NN	NN	_	18	conj	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	cotransfected	cotransfect	VBN	VBN	_	0	root	_	_
25	into	into	IN	IN	_	26	case	_	_
26	T-cells	t-cell	NNS	NNS	_	24	nmod	_	_
27	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	virus	virus	NN	NN	_	8	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	four	four	CD	CD	_	6	nummod	_	_
5	Sp1	sp1	NN	NN	_	6	compound	_	_
6	sites	site	NNS	NNS	_	2	nmod	_	_
7	did	do	VBD	VBD	_	8	aux	_	_
8	outgrow	outgrow	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	three	three	CD	CD	_	12	nummod	_	_
11	Sp1	sp1	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	8	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	35	35	CD	CD	_	15	nummod	_	_
15	days	day	NNS	NNS	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	culture	culture	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	CTG-monomer	ctg-monomer	NN	NN	_	20	compound	_	_
20	virus	virus	NN	NN	_	21	nsubj	_	_
21	outcompeted	outcompet	VBD	VBD	_	8	conj	_	_
22	the	the	DT	DT	_	24	det	_	_
23	CTG-dimer	ctg-dimer	NN	NN	_	24	compound	_	_
24	virus	virus	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	42	42	CD	CD	_	27	nummod	_	_
27	days	day	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	6	advcl	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	estimate	estimate	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	5-10	5-10	CD	CD	_	9	dep	_	_
9	%	%	NN	NN	_	10	dep	_	_
10	difference	difference	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	LTR	ltr	NN	NN	_	17	compound	_	_
17	variants	variant	NNS	NNS	_	13	nmod	_	_
18	when	when	WRB	WRB	_	19	advmod	_	_
19	compared	compare	VBN	VBN	_	6	advcl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	wild-type	wild-type	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	SCL	scl	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	related	related	JJ	JJ	_	7	amod	_	_
4	hemopoietic	hemopoietic	JJ	JJ	_	7	amod	_	_
5	helix-loop-helix	helix-loop-helix	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	1	conj	_	_
8	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	helix-loop-helix	helix-loop-helix	JJ	JJ	_	6	amod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	HLH	hlh	JJ	JJ	_	2	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	proteins	protein	NNS	NNS	_	9	nsubj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	family	family	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	include	include	VBP	VBP	_	12	acl:relcl	_	_
15	proteins	protein	NNS	NNS	_	14	dobj	_	_
16	critical	critical	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	differentiation	differentiation	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	development	development	NN	NN	_	18	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	species	species	NNS	NNS	_	18	nmod	_	_
23	ranging	range	VBG	VBG	_	22	acl	_	_
24	from	from	IN	IN	_	25	case	_	_
25	plants	plant	NNS	NNS	_	23	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	mammals	mammal	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Five	five	CD	CD	_	2	nummod	_	_
2	members	member	NNS	NNS	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	family	family	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MYC	myc	NN	NN	_	2	dep	_	_
8	,	,	,	,	_	7	punct	_	_
9	SCL	scl	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	TAL-2	tal-2	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	LYL-1	lyl-1	NN	NN	_	7	conj	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	E2A	e2a	NN	NN	_	7	conj	_	_
16	)	)	-RRB-	-RRB-	_	7	punct	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	implicated	implicate	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	oncogenic	oncogenic	JJ	JJ	_	21	amod	_	_
21	events	event	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	tumors	tumor	NNS	NNS	_	21	nmod	_	_
26	because	because	IN	IN	_	30	case	_	_
27	of	of	IN	IN	_	26	mwe	_	_
28	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
29	consistent	consistent	JJ	JJ	_	30	amod	_	_
30	involvement	involvement	NN	NN	_	18	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	chromosomal	chromosomal	JJ	JJ	_	33	amod	_	_
33	translocations	translocation	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	2	mark	_	_
2	activated	activate	VBN	VBN	_	14	advcl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	leukemias	leukemia	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	expression	expression	NN	NN	_	14	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	SCL	scl	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	LYL-1	lyl-1	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	low	low	JJ	JJ	_	0	root	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	undetectable	undetectable	JJ	JJ	_	14	conj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	normal	normal	JJ	JJ	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	populations	population	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	SCL	scl	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	11	case	_	_
5	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	megakaryocyte	megakaryocyte	NN	NN	_	5	conj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	mast	mast	NN	NN	_	10	compound	_	_
10	cell	cell	NN	NN	_	5	conj	_	_
11	populations	population	NNS	NNS	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	the	the	DT	DT	_	16	det	_	_
14	same	same	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lineages	lineage	NNS	NNS	_	11	dep	_	_
17	as	as	IN	IN	_	18	case	_	_
18	GATA-1	gata-1	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	23	det	_	_
21	zinc-finger	zinc-finger	NN	NN	_	23	compound	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	18	appos	_	_
24	)	)	-RRB-	-RRB-	_	16	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	SCL	scl	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	GATA-1	gata-1	NN	NN	_	5	conj	_	_
8	undergo	undergo	VBP	VBP	_	0	root	_	_
9	coordinate	coordinate	JJ	JJ	_	10	amod	_	_
10	modulation	modulation	NN	NN	_	8	dobj	_	_
11	during	during	IN	IN	_	15	case	_	_
12	chemically	chemically	RB	RB	_	13	advmod	_	_
13	induced	induce	VBN	VBN	_	15	amod	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	mouse	mouse	NN	NN	_	19	compound	_	_
18	erythroleukemia	erythroleukemia	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	down-modulated	down-modulate	VBN	VBN	_	8	conj	_	_
23	during	during	IN	IN	_	25	case	_	_
24	myeloid	myeloid	JJ	JJ	_	25	amod	_	_
25	differentiation	differentiation	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	K562	k562	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	8	punct	_	_
31	thus	thus	RB	RB	_	32	advmod	_	_
32	implying	imply	VBG	VBG	_	8	advcl	_	_
33	a	a	DT	DT	_	34	det	_	_
34	role	role	NN	NN	_	32	dobj	_	_
35	for	for	IN	IN	_	36	case	_	_
36	SCL	scl	NN	NN	_	34	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	erythroid	erythroid	JJ	JJ	_	40	amod	_	_
39	differentiation	differentiation	NN	NN	_	40	compound	_	_
40	events	event	NNS	NNS	_	34	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	contrast	contrast	NN	NN	_	6	dep	_	_
5	to	to	TO	TO	_	6	case	_	_
6	GATA-1	gata-1	NN	NN	_	10	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	SCL	scl	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	developing	develop	VBG	VBG	_	14	amod	_	_
14	brain	brain	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Studies	study	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	function	function	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	SCL	scl	NN	NN	_	4	nmod	_	_
7	suggest	suggest	VBP	VBP	_	0	root	_	_
8	it	it	PRP	PRP	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	important	important	JJ	JJ	_	7	ccomp	_	_
12	in	in	IN	IN	_	16	case	_	_
13	proliferation	proliferation	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	self-renewal	self-renewal	JJ	JJ	_	13	conj	_	_
16	events	event	NNS	NNS	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Transcription	transcription	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	hypersensitive	hypersensitive	JJ	JJ	_	7	amod	_	_
5	site	site	NN	NN	_	7	compound	_	_
6	HS2	hs2	NN	NN	_	7	compound	_	_
7	enhancer	enhancer	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	genome	genome	NN	NN	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	the	the	DT	DT	_	11	det	_	_
7	erythroid-specific	erythroid-specific	JJ	JJ	_	11	amod	_	_
8	hypersensitive	hypersensitive	JJ	JJ	_	11	amod	_	_
9	site	site	NN	NN	_	11	compound	_	_
10	HS2	hs2	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	12	nsubj	_	_
12	regulates	regulate	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	downstream	downstream	JJ	JJ	_	20	amod	_	_
18	beta-like	beta-like	JJ	JJ	_	20	amod	_	_
19	globin	globin	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	14	nmod	_	_
21	10-50	10-50	CD	CD	_	22	nummod	_	_
22	kilobases	kilobase	NNS	NNS	_	23	nmod:npmod	_	_
23	away	away	RB	RB	_	20	advmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HS2	hs2	NN	NN	_	6	compound	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	function	function	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	known	know	VBN	VBN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	employs	employ	VBZ	VBZ	_	0	root	_	_
5	RNA	rna	NN	NN	_	7	compound	_	_
6	protection	protection	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	4	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	analyze	analyze	VB	VB	_	4	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	status	status	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	HS2	hs2	NN	NN	_	16	compound	_	_
16	enhancer	enhancer	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	25	case	_	_
18	transfected	transfect	VBN	VBN	_	25	amod	_	_
19	recombinant	recombinant	JJ	JJ	_	25	amod	_	_
20	chloramphenicol	chloramphenicol	NN	NN	_	21	compound	_	_
21	acetyltransferase	acetyltransferase	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CAT	cat	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	plasmids	plasmid	NNS	NNS	_	12	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
3	K562	k562	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	16	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	11	nmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HS2	hs2	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	active	active	JJ	JJ	_	4	acl:relcl	_	_
12	,	,	,	,	_	16	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HS2	hs2	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	16	nsubj	_	_
16	directs	direct	VBZ	VBZ	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	synthesis	synthesis	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	long	long	JJ	JJ	_	22	amod	_	_
21	enhancer	enhancer	NN	NN	_	22	compound	_	_
22	transcripts	transcript	NNS	NNS	_	18	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubjpass	_	_
24	are	be	VBP	VBP	_	25	auxpass	_	_
25	initiated	initiate	VBN	VBN	_	22	acl:relcl	_	_
26	apparently	apparently	RB	RB	_	25	advmod	_	_
27	from	from	IN	IN	_	30	case	_	_
28	within	within	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	enhancer	enhancer	NN	NN	_	25	nmod	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	elongated	elongate	VBN	VBN	_	25	conj	_	_
33	through	through	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	intervening	intervene	VBG	VBG	_	36	amod	_	_
36	DNA	dna	NN	NN	_	32	nmod	_	_
37	into	into	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	cis-linked	cis-linked	JJ	JJ	_	41	amod	_	_
40	CAT	cat	NN	NN	_	41	compound	_	_
41	gene	gene	NN	NN	_	32	nmod	_	_
42	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	nonerythroid	nonerythroid	JJ	JJ	_	4	amod	_	_
3	HL-60	hl-60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	18	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	11	nmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HS2	hs2	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	inactive	inactive	JJ	JJ	_	4	acl:relcl	_	_
12	,	,	,	,	_	18	punct	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	enhancer	enhancer	NN	NN	_	15	compound	_	_
15	transcripts	transcript	NNS	NNS	_	18	nsubj	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	detectable	detectable	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Splitting	split	VBG	VBG	_	10	csubj	_	_
2	the	the	DT	DT	_	4	det	_	_
3	HS2	hs2	NN	NN	_	4	compound	_	_
4	enhancer	enhancer	NN	NN	_	1	dobj	_	_
5	between	between	IN	IN	_	9	case	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	tandem	tandem	JJ	JJ	_	9	amod	_	_
8	Ap1	ap1	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	1	nmod	_	_
10	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	synthesis	synthesis	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	group	group	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	enhancer	enhancer	NN	NN	_	19	compound	_	_
19	transcripts	transcript	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	results	result	VBZ	VBZ	_	10	conj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	loss	loss	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	enhancer	enhancer	NN	NN	_	26	compound	_	_
26	function	function	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	silencing	silencing	NN	NN	_	23	conj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	cis-linked	cis-linked	JJ	JJ	_	34	amod	_	_
33	CAT	cat	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	directing	direct	VBG	VBG	_	28	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	synthesis	synthesis	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	RNA	rna	NN	NN	_	4	nmod	_	_
7	through	through	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	intervening	intervene	VBG	VBG	_	10	amod	_	_
10	DNA	dna	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	10	conj	_	_
14	by	by	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	tracking	tracking	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	transcription	transcription	NN	NN	_	16	conj	_	_
19	mechanism	mechanism	NN	NN	_	2	nmod	_	_
20	,	,	,	,	_	28	punct	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HS2	hs2	NN	NN	_	23	compound	_	_
23	enhancer	enhancer	NN	NN	_	28	nsubj	_	_
24	may	may	MD	MD	_	28	aux	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	i	i	LS	LS	_	28	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	open	open	VB	VB	_	0	root	_	_
29	up	up	RP	RP	_	28	compound:prt	_	_
30	the	the	DT	DT	_	32	det	_	_
31	chromatin	chromatin	NN	NN	_	32	compound	_	_
32	structure	structure	NN	NN	_	28	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	domain	domain	NN	NN	_	32	nmod	_	_
37	and	and	CC	CC	_	28	cc	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	ii	ii	LS	LS	_	41	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	deliver	deliver	VB	VB	_	28	conj	_	_
42	enhancer	enhancer	NN	NN	_	44	compound	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	proteins	protein	NNS	NNS	_	41	dobj	_	_
45	to	to	TO	TO	_	48	case	_	_
46	the	the	DT	DT	_	48	det	_	_
47	promoter	promoter	NN	NN	_	48	compound	_	_
48	sequence	sequence	NN	NN	_	41	nmod	_	_
49	where	where	WRB	WRB	_	52	advmod	_	_
50	they	they	PRP	PRP	_	52	nsubj	_	_
51	may	may	MD	MD	_	52	aux	_	_
52	stimulate	stimulate	VB	VB	_	48	acl:relcl	_	_
53	the	the	DT	DT	_	54	det	_	_
54	transcription	transcription	NN	NN	_	52	dobj	_	_
55	of	of	IN	IN	_	57	case	_	_
56	the	the	DT	DT	_	57	det	_	_
57	gene	gene	NN	NN	_	54	nmod	_	_
58	at	at	IN	IN	_	61	case	_	_
59	the	the	DT	DT	_	61	det	_	_
60	cap	cap	NN	NN	_	61	compound	_	_
61	site	site	NN	NN	_	52	nmod	_	_
62	.	.	.	.	_	28	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	ester	ester	NN	NN	_	3	nsubj	_	_
3	reduces	reduce	VBZ	VBZ	_	0	root	_	_
4	constitutive	constitutive	JJ	JJ	_	8	amod	_	_
5	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
6	NF	nf	NN	NN	_	8	compound	_	_
7	kappa	kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	3	dobj	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	inhibits	inhibit	VBZ	VBZ	_	3	conj	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	mature	mature	JJ	JJ	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	NF	nf	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	potent	potent	JJ	JJ	_	7	amod	_	_
7	mediator	mediator	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	11	case	_	_
9	specific	specific	JJ	JJ	_	11	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	7	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	play	play	VB	VB	_	18	xcomp	_	_
21	a	a	DT	DT	_	22	det	_	_
22	role	role	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	transcription	transcription	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	HIV-1	hiv-1	NN	NN	_	28	compound	_	_
28	genome	genome	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	promonocytic	promonocytic	JJ	JJ	_	31	amod	_	_
31	leukemias	leukemia	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	little	little	JJ	JJ	_	4	amod	_	_
4	information	information	NN	NN	_	2	nsubj	_	_
5	available	available	JJ	JJ	_	4	amod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	response	response	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF	nf	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	32P-labeled	32p-labeled	JJ	JJ	_	6	amod	_	_
6	oligonucleotide	oligonucleotide	NN	NN	_	3	dobj	_	_
7	derived	derive	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	17	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
11	virus	virus	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	HIV-1	hiv-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	contains	contain	VBZ	VBZ	_	17	acl:relcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	tandem	tandem	JJ	JJ	_	23	amod	_	_
23	repeat	repeat	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	30	case	_	_
25	the	the	DT	DT	_	30	det	_	_
26	NF	nf	NN	NN	_	30	compound	_	_
27	kappa	kappa	NN	NN	_	30	compound	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	sequence	sequence	NN	NN	_	23	nmod	_	_
31	,	,	,	,	_	17	punct	_	_
32	as	as	IN	IN	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	probe	probe	NN	NN	_	3	nmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	a	a	DT	DT	_	39	det	_	_
37	gel	gel	NN	NN	_	39	compound	_	_
38	retardation	retardation	NN	NN	_	39	compound	_	_
39	assay	assay	NN	NN	_	3	nmod	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	study	study	VB	VB	_	3	xcomp	_	_
42	this	this	DT	DT	_	44	det	_	_
43	transcription	transcription	NN	NN	_	44	compound	_	_
44	factor	factor	NN	NN	_	41	dobj	_	_
45	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	7	advcl	_	_
2	this	this	DT	DT	_	3	det	_	_
3	assay	assay	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	NF	nf	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	extracts	extract	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	nuclei	nucleus	NNS	NNS	_	12	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	normal	normal	JJ	JJ	_	4	amod	_	_
4	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	12-0-tetradecanoyl	12-0-tetradecanoyl	JJ	JJ	_	7	amod	_	_
7	phorbol-13-acetate	phorbol-13-acetate	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	TPA	tpa	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	for	for	IN	IN	_	13	case	_	_
12	4-24	4-24	CD	CD	_	13	nummod	_	_
13	h	h	NN	NN	_	1	nmod	_	_
14	caused	cause	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	complete	complete	JJ	JJ	_	17	amod	_	_
17	disappearance	disappearance	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	NF	nf	NN	NN	_	21	compound	_	_
20	kappa	kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	17	nmod	_	_
22	from	from	IN	IN	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	extracts	extract	NNS	NNS	_	17	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	result	result	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	obtained	obtain	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	mature	mature	JJ	JJ	_	13	amod	_	_
9	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
10	leukemia	leukemia	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	line	line	NN	NN	_	13	compound	_	_
13	THP-1	thp-1	NN	NN	_	5	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	SP1	sp1	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	aux	_	_
7	unaffected	unaffected	JJ	JJ	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	addition	addition	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TPA	tpa	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	disappearance	disappearance	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	concentration	concentration	NN	NN	_	12	nmod:npmod	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	between	between	IN	IN	_	17	case	_	_
14	10	10	CD	CD	_	17	nummod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	50	50	CD	CD	_	14	conj	_	_
17	ng/ml	ng/ml	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	phorbol	phorbol	NN	NN	_	20	compound	_	_
20	ester	ester	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	THP-1	thp-1	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	TPA	tpa	NN	NN	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	15	det	_	_
9	new	new	JJ	JJ	_	15	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	faster-migrating	faster-migrating	JJ	JJ	_	9	dep	_	_
12	NF	nf	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	species	species	NNS	NNS	_	7	dobj	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	induced	induce	VBN	VBN	_	15	acl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Protein	protein	NN	NN	_	5	compound	_	_
2	kinase	kinase	NN	NN	_	5	compound	_	_
3	C	c	NN	NN	_	5	compound	_	_
4	inhibitor	inhibitor	NN	NN	_	5	compound	_	_
5	staurosporine	staurosporine	NN	NN	_	18	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	cyclic	cyclic	JJ	JJ	_	10	amod	_	_
10	nucleotide-dependent	nucleotide-dependent	JJ	JJ	_	14	amod	_	_
11	protein	protein	NN	NN	_	14	compound	_	_
12	kinase	kinase	NN	NN	_	14	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	14	compound	_	_
14	HA-1004	ha-1004	NN	NN	_	5	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	also	also	RB	RB	_	18	advmod	_	_
17	dramatically	dramatically	RB	RB	_	18	advmod	_	_
18	reduced	reduce	VBD	VBD	_	0	root	_	_
19	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	NF	nf	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	Finally	finally	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	TPA	tpa	NN	NN	_	4	compound	_	_
4	addition	addition	NN	NN	_	10	nsubj	_	_
5	to	to	TO	TO	_	6	case	_	_
6	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
7	infected	infect	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	HIV-1	hiv-1	NN	NN	_	7	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	replication	replication	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	10	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	determined	determine	VBN	VBN	_	10	advcl	_	_
16	by	by	IN	IN	_	19	case	_	_
17	reverse	reverse	JJ	JJ	_	19	amod	_	_
18	transcriptase	transcriptase	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	concentration-dependent	concentration-dependent	JJ	JJ	_	24	amod	_	_
24	manner	manner	NN	NN	_	10	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	in	in	IN	IN	_	6	case	_	_
5	striking	striking	JJ	JJ	_	6	amod	_	_
6	contrast	contrast	NN	NN	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	increase	increase	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
12	NF	nf	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	replication	replication	NN	NN	_	14	conj	_	_
18	induced	induce	VBN	VBN	_	14	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	phorbol	phorbol	NN	NN	_	21	compound	_	_
21	esters	ester	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	promonocytic	promonocytic	JJ	JJ	_	25	amod	_	_
24	leukemia	leukemia	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	18	nmod	_	_
26	U937	u937	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	HL-60	hl-60	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	6	punct	_	_
30	and	and	CC	CC	_	6	cc	_	_
31	emphasize	emphasize	VBP	VBP	_	6	conj	_	_
32	the	the	DT	DT	_	33	det	_	_
33	importance	importance	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	35	mark	_	_
35	studying	study	VBG	VBG	_	33	acl	_	_
36	cytokine	cytokine	NN	NN	_	37	compound	_	_
37	regulation	regulation	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	39	case	_	_
39	HIV-1	hiv-1	NN	NN	_	37	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	normal	normal	JJ	JJ	_	42	amod	_	_
42	monocytes	monocyte	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	6	punct	_	_

1	Ablation	ablation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	transplanted	transplant	VBN	VBN	_	6	amod	_	_
4	HTLV-I	htlv-i	NN	NN	_	5	nmod:npmod	_	_
5	Tax-transformed	tax-transformed	JJ	JJ	_	6	amod	_	_
6	tumors	tumor	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	mice	mouse	NNS	NNS	_	6	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	antisense	antisense	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
16	published	publish	VBN	VBN	_	17	amod	_	_
17	erratum	erratum	NN	NN	_	18	nsubj	_	_
18	appears	appear	VBZ	VBZ	_	1	dep	_	_
19	in	in	IN	IN	_	22	case	_	_
20	Science	Science	NNP	NNP	_	22	compound	_	_
21	1993	1993	CD	CD	_	22	nummod	_	_
22	Mar	Mar	NNP	NNP	_	18	nmod	_	_
23	12	12	CD	CD	_	22	nummod	_	_
24	;	;	:	:	_	22	punct	_	_
25	259	259	CD	CD	_	22	nummod	_	_
26	(	(	-LRB-	-LRB-	_	22	punct	_	_
27	5101	5101	CD	CD	_	22	nummod	_	_
28	)	)	-RRB-	-RRB-	_	22	punct	_	_
29	:	:	:	:	_	22	punct	_	_
30	1523	1523	CD	CD	_	22	nummod	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_

1	Mice	mouse	NNS	NNS	_	15	nsubj	_	_
2	transgenic	transgenic	JJ	JJ	_	1	amod	_	_
3	for	for	IN	IN	_	14	case	_	_
4	the	the	DT	DT	_	14	det	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	T	t	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	leukemia	leukemia	NN	NN	_	9	compound	_	_
9	virus	virus	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HTLV-I	htlv-i	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	Tax	tax	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	2	nmod	_	_
15	develop	develop	VBP	VBP	_	0	root	_	_
16	fibroblastic	fibroblastic	JJ	JJ	_	17	amod	_	_
17	tumors	tumor	NNS	NNS	_	15	dobj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	express	express	VBP	VBP	_	17	acl:relcl	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	nmod:npmod	_	_
21	B-inducible	b-inducible	JJ	JJ	_	23	amod	_	_
22	early	early	JJ	JJ	_	23	amod	_	_
23	genes	gene	NNS	NNS	_	19	dobj	_	_
24	.	.	.	.	_	15	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	inhibition	inhibition	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	antisense	antisense	JJ	JJ	_	10	amod	_	_
10	oligodeoxynucleotides	oligodeoxynucleotide	NNS	NNS	_	3	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	ODNs	odn	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	inhibited	inhibit	VBD	VBD	_	0	root	_	_
15	growth	growth	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	these	these	DT	DT	_	20	det	_	_
18	culture-adapted	culture-adapted	JJ	JJ	_	20	amod	_	_
19	Tax-transformed	tax-transformed	JJ	JJ	_	20	amod	_	_
20	fibroblasts	fibroblast	NNS	NNS	_	15	nmod	_	_
21	as	as	RB	RB	_	20	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	an	a	DT	DT	_	28	det	_	_
25	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	28	amod	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	lymphocyte	lymphocyte	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	20	conj	_	_
29	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	antisense	antisense	JJ	JJ	_	5	amod	_	_
5	inhibition	inhibition	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	itself	itself	PRP	PRP	_	7	nmod:npmod	_	_
9	had	have	VBD	VBD	_	0	root	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	apparent	apparent	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	9	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	growth	growth	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Mice	mouse	NNS	NNS	_	9	nsubj	_	_
2	treated	treat	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	4	case	_	_
4	antisense	antisense	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	ODNs	odn	NNS	NNS	_	4	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	rapid	rapid	JJ	JJ	_	11	amod	_	_
11	regression	regression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transplanted	transplant	VBN	VBN	_	14	amod	_	_
14	fibrosarcomas	fibrosarcoma	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	9	nsubj	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	cop	_	_
9	necessary	necessary	JJ	JJ	_	2	ccomp	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	maintenance	maintenance	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	malignant	malignant	JJ	JJ	_	16	amod	_	_
16	phenotype	phenotype	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	2	cc	_	_
18	provides	provide	VBZ	VBZ	_	2	conj	_	_
19	a	a	DT	DT	_	21	det	_	_
20	therapeutic	therapeutic	JJ	JJ	_	21	amod	_	_
21	approach	approach	NN	NN	_	18	dobj	_	_
22	for	for	IN	IN	_	24	case	_	_
23	HTLV-I-associated	htlv-i-associated	JJ	JJ	_	24	amod	_	_
24	disease	disease	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	anti-CD3	anti-cd3	JJ	JJ	_	5	amod	_	_
4	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
5	antibody-induced	antibody-induced	JJ	JJ	_	7	amod	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	proliferation	proliferation	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	isoproterenol	isoproterenol	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	prostaglandin	prostaglandin	NN	NN	_	15	compound	_	_
15	E2	e2	NN	NN	_	9	conj	_	_
16	either	either	CC	CC	_	9	dep	_	_
17	alone	alone	RB	RB	_	16	dep	_	_
18	or	or	CC	CC	_	16	cc	_	_
19	in	in	IN	IN	_	20	case	_	_
20	combination	combination	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	1	1	LS	LS	_	8	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	purpose	purpose	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	studies	study	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	investigate	investigate	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	modulation	modulation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	proliferation	proliferation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	obtained	obtain	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
23	blood	blood	NN	NN	_	20	nmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	DEX	dex	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	25	punct	_	_
30	isoproterenol	isoproterenol	NN	NN	_	25	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	ISO	iso	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	25	punct	_	_
35	and	and	CC	CC	_	25	cc	_	_
36	prostaglandin	prostaglandin	NN	NN	_	37	compound	_	_
37	E2	e2	NN	NN	_	25	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	PGE2	pge2	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	former	former	JJ	JJ	_	4	amod	_	_
3	two	two	CD	CD	_	4	nummod	_	_
4	substances	substance	NNS	NNS	_	5	nsubj	_	_
5	interact	interact	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	via	via	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	beta-adrenergic	beta-adrenergic	JJ	JJ	_	11	conj	_	_
14	receptors	receptor	NNS	NNS	_	5	nmod	_	_
15	respectively	respectively	RB	RB	_	5	advmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	occupied	occupy	VBN	VBN	_	14	advcl	_	_
3	by	by	IN	IN	_	6	case	_	_
4	their	they	PRP$	PRP$	_	6	nmod:poss	_	_
5	natural	natural	JJ	JJ	_	6	amod	_	_
6	ligands	ligand	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	glucocorticosteroids	glucocorticosteroid	NNS	NNS	_	6	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	catecholamines	catecholamine	NNS	NNS	_	8	conj	_	_
11	,	,	,	,	_	14	punct	_	_
12	these	these	DT	DT	_	13	det	_	_
13	receptors	receptor	NNS	NNS	_	14	nsubj	_	_
14	have	have	VBP	VBP	_	0	root	_	_
15	a	a	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	modulating	modulate	VBG	VBG	_	14	advcl	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	function	function	NN	NN	_	18	dobj	_	_
21	during	during	IN	IN	_	22	case	_	_
22	stress	stress	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	inflammatory	inflammatory	JJ	JJ	_	4	amod	_	_
4	response	response	NN	NN	_	9	nmod	_	_
5	increased	increase	VBN	VBN	_	6	amod	_	_
6	levels	level	NNS	NNS	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PGE2	pge2	NN	NN	_	6	nmod	_	_
9	bind	bind	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	thus	thus	RB	RB	_	9	advmod	_	_
18	alter	alter	VBP	VBP	_	9	dep	_	_
19	responsiveness	responsiveness	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Proliferation	proliferation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	immobilized	immobilize	VBN	VBN	_	11	amod	_	_
9	anti-CD3	anti-cd3	JJ	JJ	_	11	amod	_	_
10	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
11	antibody	antibody	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	mAb	mab	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	presence	presence	NN	NN	_	6	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	absence	absence	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	an	a	DT	DT	_	24	det	_	_
22	additional	additional	JJ	JJ	_	24	amod	_	_
23	costimulatory	costimulatory	JJ	JJ	_	24	amod	_	_
24	signal	signal	NN	NN	_	17	nmod	_	_
25	delivered	deliver	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	anti-CD28	anti-cd28	JJ	JJ	_	28	amod	_	_
28	mAb	mab	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	2	2	LS	LS	_	14	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Various	various	JJ	JJ	_	5	amod	_	_
4	physiologic	physiologic	JJ	JJ	_	5	amod	_	_
5	concentrations	concentration	NNS	NNS	_	14	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	DEX	dex	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	ISO	iso	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	or	or	CC	CC	_	7	cc	_	_
12	PGE2	pge2	NN	NN	_	7	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	added	add	VBN	VBN	_	0	root	_	_
15	at	at	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	time	time	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	initiation	initiation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cultures	culture	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	14	cc	_	_
24	subsequent	subsequent	JJ	JJ	_	25	amod	_	_
25	proliferation	proliferation	NN	NN	_	32	nsubjpass	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	unstimulated	unstimulated	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	determined	determine	VBN	VBN	_	14	conj	_	_
33	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	physiologic	physiologic	JJ	JJ	_	6	amod	_	_
6	concentrations	concentration	NNS	NNS	_	13	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	three	three	CD	CD	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	agents	agent	NNS	NNS	_	9	nmod	_	_
13	inhibit	inhibit	VBP	VBP	_	3	ccomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	anti-CD3	anti-cd3	JJ	JJ	_	16	amod	_	_
16	mAb-induced	mab-induced	JJ	JJ	_	17	amod	_	_
17	proliferation	proliferation	NN	NN	_	13	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	3	3	LS	LS	_	18	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Although	although	IN	IN	_	8	mark	_	_
4	DEX	dex	NN	NN	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	PGE2	pge2	NN	NN	_	4	conj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	equipotent	equipotent	JJ	JJ	_	18	advcl	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	suppressing	suppressing	JJ	JJ	_	8	advcl	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	18	punct	_	_
14	ISO	iso	NN	NN	_	18	nsubj	_	_
15	was	be	VBD	VBD	_	18	cop	_	_
16	much	much	RB	RB	_	17	advmod	_	_
17	less	less	RBR	RBR	_	18	advmod	_	_
18	effective	effective	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	4	4	LS	LS	_	18	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Because	because	IN	IN	_	14	mark	_	_
4	concomitant	concomitant	JJ	JJ	_	5	amod	_	_
5	elevations	elevation	NNS	NNS	_	14	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	substances	substance	NNS	NNS	_	9	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	occur	occur	VB	VB	_	18	advcl	_	_
15	,	,	,	,	_	18	punct	_	_
16	experiments	experiment	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	performed	perform	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	determine	determine	VB	VB	_	18	xcomp	_	_
21	the	the	DT	DT	_	24	det	_	_
22	T-cell	t-cell	NN	NN	_	24	compound	_	_
23	inhibitory	inhibitory	JJ	JJ	_	24	amod	_	_
24	effects	effect	NNS	NNS	_	20	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	DEX	dex	NN	NN	_	24	nmod	_	_
27	together	together	RB	RB	_	30	advmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	either	either	CC	CC	_	30	cc:preconj	_	_
30	PGE2	pge2	NN	NN	_	24	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	ISO	iso	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	18	punct	_	_

1	Synergistic	synergistic	JJ	JJ	_	2	amod	_	_
2	suppression	suppression	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	proliferation	proliferation	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	when	when	WRB	WRB	_	23	advmod	_	_
9	various	various	JJ	JJ	_	10	amod	_	_
10	concentrations	concentration	NNS	NNS	_	23	nsubjpass	_	_
11	of	of	IN	IN	_	12	case	_	_
12	DEX	dex	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	PGE2	pge2	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	12	cc	_	_
18	DEX	dex	NN	NN	_	12	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	ISO	iso	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	added	add	VBN	VBN	_	7	advcl	_	_
24	to	to	TO	TO	_	25	case	_	_
25	cultures	culture	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	synergistic	synergistic	JJ	JJ	_	3	amod	_	_
3	suppression	suppression	NN	NN	_	7	nsubjpass	_	_
4	could	could	MD	MD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	explained	explain	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cAMP	camp	NN	NN	_	13	compound	_	_
13	accumulation	accumulation	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	stimulated	stimulate	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	DEX	dex	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	PGE2	pge2	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	5	5	LS	LS	_	15	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Finally	finally	RB	RB	_	15	advmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	addition	addition	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	anti-CD28	anti-cd28	JJ	JJ	_	9	amod	_	_
9	mAb	mab	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	anti-CD3	anti-cd3	JJ	JJ	_	12	amod	_	_
12	mAb-stimulated	mab-stimulated	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	overcame	overcome	VBD	VBD	_	0	root	_	_
16	much	much	JJ	JJ	_	15	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	suppression	suppression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	proliferation	proliferation	NN	NN	_	19	nmod	_	_
22	induced	induce	VBN	VBN	_	19	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	PGE2	pge2	NN	NN	_	22	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	ISO	iso	NN	NN	_	24	conj	_	_
27	but	but	CC	CC	_	15	cc	_	_
28	less	less	RBR	RBR	_	29	advmod	_	_
29	so	so	RB	RB	_	15	advmod	_	_
30	than	than	IN	IN	_	31	case	_	_
31	that	that	DT	DT	_	29	nmod	_	_
32	induced	induce	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	34	case	_	_
34	DEX	dex	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	Targeted	target	VBN	VBN	_	2	amod	_	_
2	degradation	degradation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-Fos	c-fos	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	v-Fos	v-fos	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	phosphorylation-dependent	phosphorylation-dependent	JJ	JJ	_	13	amod	_	_
13	signal	signal	NN	NN	_	2	nmod	_	_
14	on	on	IN	IN	_	15	case	_	_
15	c-Jun	c-jun	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proto-oncogene	proto-oncogene	NN	NN	_	3	compound	_	_
3	products	product	NNS	NNS	_	7	nsubj	_	_
4	c-Fos	c-fos	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-Jun	c-jun	NN	NN	_	4	conj	_	_
7	heterodimerize	heterodimerize	VBP	VBP	_	0	root	_	_
8	through	through	IN	IN	_	11	case	_	_
9	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
10	leucine	leucine	NN	NN	_	11	compound	_	_
11	zippers	zipper	NNS	NNS	_	7	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	form	form	VB	VB	_	7	xcomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	heterodimer	heterodimer	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	14	case	_	_
10	signal-dependent	signal-dependent	JJ	JJ	_	14	amod	_	_
11	phosphorylation	phosphorylation	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	dephosphorylation	dephosphorylation	NN	NN	_	11	conj	_	_
14	events	event	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	stability	stability	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-Fos	c-fos	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	also	also	RB	RB	_	10	advmod	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	controlled	control	VBN	VBN	_	6	xcomp	_	_
11	by	by	IN	IN	_	14	case	_	_
12	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
13	signal	signal	NN	NN	_	14	compound	_	_
14	transduction	transduction	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	8	case	_	_
2	transient	transient	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	8	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	vitro	vitro	FW	FW	_	5	dep	_	_
7	degradation	degradation	NN	NN	_	3	conj	_	_
8	experiments	experiment	NNS	NNS	_	15	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	stability	stability	NN	NN	_	15	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	c-Fos	c-fos	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	decreased	decrease	VBN	VBN	_	0	root	_	_
16	when	when	WRB	WRB	_	20	advmod	_	_
17	the	the	DT	DT	_	18	det	_	_
18	protein	protein	NN	NN	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	aux	_	_
20	dimerized	dimerized	JJ	JJ	_	15	advcl	_	_
21	with	with	IN	IN	_	23	case	_	_
22	phosphorylated	phosphorylate	VBN	VBN	_	23	amod	_	_
23	c-Jun	c-jun	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	c-Jun	c-jun	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	10	nsubj	_	_
3	isolated	isolate	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	7	case	_	_
5	phorbol	phorbol	NN	NN	_	6	nmod:npmod	_	_
6	ester-induced	ester-induced	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	target	target	VB	VB	_	0	root	_	_
11	c-Fos	c-fos	NN	NN	_	10	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	degradation	degradation	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	suggests	suggest	VBZ	VBZ	_	10	ccomp	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	c-Fos	c-fos	NN	NN	_	21	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	transiently	transiently	RB	RB	_	21	advmod	_	_
21	stabilized	stabilize	VBN	VBN	_	16	ccomp	_	_
22	after	after	IN	IN	_	23	case	_	_
23	stimulation	stimulation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	growth	growth	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	v-Fos	v-fos	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	retroviral	retroviral	JJ	JJ	_	6	amod	_	_
6	counterpart	counterpart	NN	NN	_	2	appos	_	_
7	of	of	IN	IN	_	8	case	_	_
8	c-Fos	c-fos	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	susceptible	susceptible	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	degradation	degradation	NN	NN	_	12	nmod	_	_
15	targeted	target	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	c-Jun	c-jun	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Mutations	mutation	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Pit-1	pit-1	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	children	child	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	combined	combined	JJ	JJ	_	12	amod	_	_
10	pituitary	pituitary	JJ	JJ	_	12	amod	_	_
11	hormone	hormone	NN	NN	_	12	compound	_	_
12	deficiency	deficiency	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Pit-1	pit-1	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	pituitary-specific	pituitary-specific	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	binds	bind	VBZ	VBZ	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	8	nmod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	transactivates	transactivate	VBZ	VBZ	_	8	conj	_	_
12	promoters	promoter	NNS	NNS	_	8	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	hormone	hormone	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	prolactin	prolactin	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	12	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	three	three	CD	CD	_	5	nummod	_	_
3	unrelated	unrelated	JJ	JJ	_	5	amod	_	_
4	Japanese	japanese	JJ	JJ	_	5	amod	_	_
5	children	child	NNS	NNS	_	13	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	combined	combined	JJ	JJ	_	10	amod	_	_
8	pituitary	pituitary	JJ	JJ	_	10	amod	_	_
9	hormone	hormone	NN	NN	_	10	compound	_	_
10	deficiency	deficiency	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	identified	identify	VBD	VBD	_	0	root	_	_
14	three	three	CD	CD	_	16	nummod	_	_
15	point	point	NN	NN	_	16	compound	_	_
16	mutations	mutation	NNS	NNS	_	13	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Pit-1	pit-1	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	Pro24Leu	pro24leu	NN	NN	_	16	appos	_	_
23	,	,	,	,	_	22	punct	_	_
24	Arg143Gln	arg143gln	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	Arg271Trp	arg271trp	NN	NN	_	22	conj	_	_
28	,	,	,	,	_	16	punct	_	_
29	located	located	JJ	JJ	_	16	amod	_	_
30	on	on	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	major	major	JJ	JJ	_	34	amod	_	_
33	transactivation	transactivation	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	29	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	POU-specific	pou-specific	JJ	JJ	_	37	amod	_	_
37	domain	domain	NN	NN	_	34	appos	_	_
38	,	,	,	,	_	37	punct	_	_
39	and	and	CC	CC	_	37	cc	_	_
40	POU-homeodomain	pou-homeodomain	NN	NN	_	37	conj	_	_
41	,	,	,	,	_	34	punct	_	_
42	respectively	respectively	RB	RB	_	29	advmod	_	_
43	.	.	.	.	_	13	punct	_	_

1	Calcitriol	calcitriol	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	hematolymphopoietrope	hematolymphopoietrope	NN	NN	_	1	dep	_	_
5	?	?	.	.	_	4	punct	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	7	punct	_	_
7	editorial	editorial	NN	NN	_	1	dep	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	MEDLINE	medline	NN	NN	_	3	compound	_	_
3	search	search	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	English-language	english-language	JJ	JJ	_	7	amod	_	_
7	literature	literature	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	conducted	conduct	VBN	VBN	_	0	root	_	_
10	using	use	VBG	VBG	_	9	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	indexing	indexing	NN	NN	_	13	compound	_	_
13	terms	term	NNS	NNS	_	10	dobj	_	_
14	'	'	``	``	_	15	punct	_	_
15	immunology	immunology	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	calcitriol	calcitriol	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	vitamin	vitamin	NN	NN	_	20	compound	_	_
20	D	d	NN	NN	_	15	conj	_	_
21	'	'	''	''	_	15	punct	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	identify	identify	VB	VB	_	9	xcomp	_	_
24	studies	study	NNS	NNS	_	23	dobj	_	_
25	indicating	indicate	VBG	VBG	_	24	acl	_	_
26	a	a	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	for	for	IN	IN	_	29	case	_	_
29	calcitriol	calcitriol	NN	NN	_	27	nmod	_	_
30	as	as	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	primary	primary	JJ	JJ	_	33	amod	_	_
33	immunomodulator	immunomodulator	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	Sixty-six	sixty-six	CD	CD	_	2	nummod	_	_
2	papers	papers	NNS	NNS	_	11	nsubjpass	_	_
3	published	publish	VBN	VBN	_	2	acl	_	_
4	between	between	IN	IN	_	5	case	_	_
5	January	January	NNP	NNP	_	3	nmod	_	_
6	1956	1956	CD	CD	_	5	nummod	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	June	June	NNP	NNP	_	5	conj	_	_
9	1991	1991	CD	CD	_	8	nummod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Forty-five	forty-five	CD	CD	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	reports	report	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	cited	cite	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	review	review	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	an	a	DT	DT	_	11	det	_	_
6	endocrine	endocrine	NN	NN	_	11	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	autocrine	autocrine	NN	NN	_	6	conj	_	_
9	and/or	and/or	CC	CC	_	6	cc	_	_
10	paracrine	paracrine	NN	NN	_	6	conj	_	_
11	role	role	NN	NN	_	4	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	calcitriol	calcitriol	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	regulation	regulation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	unifying	unifying	JJ	JJ	_	3	amod	_	_
3	hypothesis	hypothesis	NN	NN	_	6	nsubj	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	yet	yet	RB	RB	_	6	advmod	_	_
6	emerged	emerge	VBN	VBN	_	0	root	_	_
7	explaining	explain	VBG	VBG	_	6	xcomp	_	_
8	this	this	DT	DT	_	9	det	_	_
9	collection	collection	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	data	datum	NNS	NNS	_	9	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	provides	provide	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	brief	brief	JJ	JJ	_	6	amod	_	_
6	review	review	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	properties	property	NNS	NNS	_	6	nmod	_	_
10	currently	currently	RB	RB	_	11	advmod	_	_
11	attributed	attribute	VBN	VBN	_	9	acl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	calcitriol	calcitriol	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	protein	protein	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	C	c	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	elevation	elevation	NN	NN	_	1	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cAMP	camp	NN	NN	_	7	nmod	_	_
10	interact	interact	VBP	VBP	_	0	root	_	_
11	synergistically	synergistically	RB	RB	_	10	advmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	raise	raise	VB	VB	_	10	xcomp	_	_
14	c-Fos	c-fos	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	AP-1	ap-1	NN	NN	_	14	conj	_	_
17	activity	activity	NN	NN	_	13	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	earlier	earlier	RBR	RBR	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	17	nmod	_	_
9	activation	activation	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PKC	pkc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	enhances	enhance	VBZ	VBZ	_	4	ccomp	_	_
18	the	the	DT	DT	_	25	det	_	_
19	cyclic	cyclic	JJ	JJ	_	21	amod	_	_
20	adenosine	adenosine	NN	NN	_	21	compound	_	_
21	monophosphate	monophosphate	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	cAMP	camp	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	accumulation	accumulation	NN	NN	_	17	dobj	_	_
26	induced	induce	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	30	case	_	_
28	adenosine	adenosine	NN	NN	_	30	compound	_	_
29	receptor	receptor	NN	NN	_	30	compound	_	_
30	stimulation	stimulation	NN	NN	_	26	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	activation	activation	NN	NN	_	30	conj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	Gs	gs	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	we	we	PRP	PRP	_	5	nsubj	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	therefore	therefore	RB	RB	_	5	advmod	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	phorbol	phorbol	NN	NN	_	11	compound	_	_
11	ester	ester	NN	NN	_	7	nmod	_	_
12	PMA	pma	NN	NN	_	11	dep	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	phorbol	phorbol	NN	NN	_	16	compound	_	_
15	12-myristate	12-myristate	NN	NN	_	16	compound	_	_
16	13-acetate	13-acetate	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	stimulates	stimulate	VBZ	VBZ	_	11	acl:relcl	_	_
20	PKC	pkc	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	a	a	DT	DT	_	23	det	_	_
23	combination	combination	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	adenosine	adenosine	NN	NN	_	28	compound	_	_
27	receptor	receptor	NN	NN	_	28	compound	_	_
28	agonist	agonist	NN	NN	_	23	nmod	_	_
29	NECA	neca	NN	NN	_	28	dep	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	5'-(N-ethyl)-carboxamido	5'-(n-ethyl)-carboxamido	JJ	JJ	_	32	amod	_	_
32	adenosine	adenosine	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	forskolin	forskolin	NN	NN	_	28	conj	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	raise	raise	VB	VB	_	19	xcomp	_	_
38	cAMP	camp	NN	NN	_	37	dobj	_	_
39	,	,	,	,	_	7	punct	_	_
40	on	on	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	levels	level	NNS	NNS	_	7	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	c-Fos	c-fos	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	Jun	jun	NN	NN	_	44	conj	_	_
47	and	and	CC	CC	_	42	cc	_	_
48	on	on	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	binding	bind	VBG	VBG	_	42	conj	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	transcriptional	transcriptional	JJ	JJ	_	53	amod	_	_
53	activity	activity	NN	NN	_	50	conj	_	_
54	of	of	IN	IN	_	57	case	_	_
55	the	the	DT	DT	_	57	det	_	_
56	transcription	transcription	NN	NN	_	57	compound	_	_
57	factor	factor	NN	NN	_	50	nmod	_	_
58	,	,	,	,	_	57	punct	_	_
59	activator	activator	NN	NN	_	60	compound	_	_
60	protein-1	protein-1	NN	NN	_	57	appos	_	_
61	(	(	-LRB-	-LRB-	_	62	punct	_	_
62	AP-1	ap-1	NN	NN	_	60	appos	_	_
63	)	)	-RRB-	-RRB-	_	62	punct	_	_
64	.	.	.	.	_	5	punct	_	_

1	PMA	pma	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	caused	cause	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	concentration-	concentration-	NN	NN	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	time-dependent	time-dependent	JJ	JJ	_	5	conj	_	_
8	increase	increase	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	14	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	c-Fos	c-fos	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Jun	jun	NN	NN	_	11	conj	_	_
14	immunoreactivity	immunoreactivity	NN	NN	_	8	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	contrast	contrast	NN	NN	_	19	dep	_	_
17	to	to	TO	TO	_	19	case	_	_
18	cAMP	camp	NN	NN	_	19	compound	_	_
19	elevation	elevation	NN	NN	_	3	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	had	have	VBD	VBD	_	19	acl:relcl	_	_
22	only	only	RB	RB	_	25	advmod	_	_
23	a	a	DT	DT	_	25	det	_	_
24	slight	slight	JJ	JJ	_	25	amod	_	_
25	effect	effect	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	PMA	pma	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	the	the	DT	DT	_	5	det	_	_
5	combination	combination	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NECA	neca	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	forskolin	forskolin	NN	NN	_	7	conj	_	_
10	acted	act	VBD	VBD	_	0	root	_	_
11	together	together	RB	RB	_	10	advmod	_	_
12	either	either	CC	CC	_	14	dep	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	increase	increase	VB	VB	_	10	ccomp	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	c-Fos	c-fos	NN	NN	_	14	dobj	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	or	or	CC	CC	_	14	cc	_	_
19	decrease	decrease	VB	VB	_	14	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Jun	jun	NN	NN	_	19	dobj	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	levels	level	NNS	NNS	_	14	dobj	_	_
25	as	as	RB	RB	_	28	advmod	_	_
26	well	well	RB	RB	_	28	advmod	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	increasing	increase	VBG	VBG	_	14	advcl	_	_
29	AP-1	ap-1	NN	NN	_	30	compound	_	_
30	binding	binding	NN	NN	_	28	dobj	_	_
31	,	,	,	,	_	28	punct	_	_
32	as	as	IN	IN	_	33	mark	_	_
33	judged	judge	VBN	VBN	_	28	advcl	_	_
34	by	by	IN	IN	_	36	case	_	_
35	gel-shift	gel-shift	NN	NN	_	36	compound	_	_
36	assay	assay	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	28	punct	_	_
38	and	and	CC	CC	_	28	cc	_	_
39	AP-1	ap-1	NN	NN	_	41	compound	_	_
40	transcriptional	transcriptional	JJ	JJ	_	41	amod	_	_
41	activity	activity	NN	NN	_	28	conj	_	_
42	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	3	advmod	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	was	be	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	clear-cut	clear-cut	JJ	JJ	_	6	amod	_	_
6	synergy	synergy	NN	NN	_	3	nsubj	_	_
7	between	between	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	PKC	pkc	NN	NN	_	10	compound	_	_
10	stimulator	stimulator	NN	NN	_	3	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	15	det	_	_
13	cAMP	camp	NN	NN	_	15	compound	_	_
14	elevating	elevating	NN	NN	_	15	compound	_	_
15	agents	agent	NNS	NNS	_	10	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	simultaneous	simultaneous	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PKC	pkc	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	elevation	elevation	NN	NN	_	7	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cAMP	camp	NN	NN	_	11	nmod	_	_
14	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
15	to	to	TO	TO	_	20	case	_	_
16	an	a	DT	DT	_	20	det	_	_
17	enhanced	enhance	VBN	VBN	_	20	amod	_	_
18	AP-1	ap-1	NN	NN	_	20	compound	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	14	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	T-leukemia	t-leukemia	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
28	that	that	IN	IN	_	40	mark	_	_
29	the	the	DT	DT	_	32	det	_	_
30	previously	previously	RB	RB	_	31	advmod	_	_
31	observed	observe	VBN	VBN	_	32	amod	_	_
32	interaction	interaction	NN	NN	_	40	nsubj	_	_
33	between	between	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	parallel	parallel	JJ	JJ	_	38	amod	_	_
36	signal	signal	NN	NN	_	38	compound	_	_
37	transduction	transduction	NN	NN	_	38	compound	_	_
38	pathways	pathway	NNS	NNS	_	32	nmod	_	_
39	may	may	MD	MD	_	40	aux	_	_
40	have	have	VB	VB	_	27	ccomp	_	_
41	functional	functional	JJ	JJ	_	42	amod	_	_
42	consequences	consequence	NNS	NNS	_	40	dobj	_	_
43	at	at	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	level	level	NN	NN	_	40	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	gene	gene	NN	NN	_	48	compound	_	_
48	transcription	transcription	NN	NN	_	45	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	use	use	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	interferon-gamma-treated	interferon-gamma-treated	JJ	JJ	_	6	amod	_	_
5	U937	u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	chemiluminescence	chemiluminescence	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	2	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	detect	detect	VB	VB	_	2	acl	_	_
12	red	red	JJ	JJ	_	13	amod	_	_
13	cell	cell	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	platelet	platelet	NN	NN	_	13	conj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	granulocyte	granulocyte	NN	NN	_	18	compound	_	_
18	antibodies	antibody	NNS	NNS	_	13	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	potential	potential	JJ	JJ	_	22	amod	_	_
21	clinical	clinical	JJ	JJ	_	22	amod	_	_
22	significance	significance	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	chemiluminescent	chemiluminescent	JJ	JJ	_	6	amod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CL	cl	JJ	JJ	_	2	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	response	response	NN	NN	_	20	nsubjpass	_	_
7	of	of	IN	IN	_	13	case	_	_
8	interferon-gamma-treated	interferon-gamma-treated	JJ	JJ	_	9	amod	_	_
9	U937	u937	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IFN-U937	ifn-u937	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	sensitized	sensitize	VBN	VBN	_	17	amod	_	_
16	target	target	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	used	use	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	detect	detect	VB	VB	_	20	xcomp	_	_
23	red	red	JJ	JJ	_	24	amod	_	_
24	cell	cell	NN	NN	_	22	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	platelet	platelet	NN	NN	_	24	conj	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	granulocyte	granulocyte	NN	NN	_	29	compound	_	_
29	antibodies	antibody	NNS	NNS	_	24	conj	_	_
30	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	clone	clone	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	U937	u937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	selected	select	VBN	VBN	_	0	root	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	expressed	express	VBD	VBD	_	7	dep	_	_
10	Fc	fc	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	I	i	NN	NN	_	9	dobj	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	Fc	fc	NN	NN	_	16	compound	_	_
15	gamma	gamma	NN	NN	_	16	compound	_	_
16	RI	ri	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	which	which	WDT	WDT	_	30	nsubj	_	_
20	,	,	,	,	_	30	punct	_	_
21	after	after	IN	IN	_	22	case	_	_
22	incubation	incubation	NN	NN	_	30	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	IFN-gamma	ifn-gamma	NN	NN	_	22	nmod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	72	72	CD	CD	_	27	nummod	_	_
27	h	h	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	30	punct	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	capable	capable	JJ	JJ	_	9	conj	_	_
31	of	of	IN	IN	_	32	mark	_	_
32	generating	generate	VBG	VBG	_	30	advcl	_	_
33	high	high	JJ	JJ	_	34	amod	_	_
34	levels	level	NNS	NNS	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	lucigenin-enhanced	lucigenin-enhanced	JJ	JJ	_	37	amod	_	_
37	CL	cl	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CL	cl	NN	NN	_	3	compound	_	_
3	responses	response	NNS	NNS	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	IFN-U937	ifn-u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	6	conj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	sensitized	sensitize	VBN	VBN	_	15	amod	_	_
14	red	red	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	3	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	platelets	platelet	NNS	NNS	_	15	conj	_	_
18	or	or	CC	CC	_	15	cc	_	_
19	granulocytes	granulocyte	NNS	NNS	_	15	conj	_	_
20	were	be	VBD	VBD	_	22	auxpass	_	_
21	then	then	RB	RB	_	22	advmod	_	_
22	compared	compare	VBN	VBN	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	Assays	assay	NNS	NNS	_	10	nsubj	_	_
2	using	use	VBG	VBG	_	1	acl	_	_
3	monocytes	monocyte	NNS	NNS	_	2	dobj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	IFN-U937	ifn-u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	10	cop	_	_
8	of	of	IN	IN	_	10	case	_	_
9	comparable	comparable	JJ	JJ	_	10	amod	_	_
10	sensitivity	sensitivity	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	detection	detection	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	antibodies	antibody	NNS	NNS	_	12	nmod	_	_
15	against	against	IN	IN	_	18	case	_	_
16	all	all	DT	DT	_	18	det	_	_
17	three	three	CD	CD	_	18	nummod	_	_
18	types	type	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	target	target	NN	NN	_	21	compound	_	_
21	cell	cell	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	use	use	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	IFN-U937	ifn-u937	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	interassay	interassay	JJ	JJ	_	11	amod	_	_
11	variation	variation	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	simplified	simplify	VBD	VBD	_	9	conj	_	_
14	assay	assay	NN	NN	_	15	compound	_	_
15	performance	performance	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	potential	potential	JJ	JJ	_	4	amod	_	_
3	clinical	clinical	JJ	JJ	_	4	amod	_	_
4	usefulness	usefulness	NN	NN	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	CL	cl	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	suggested	suggest	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IFN-U937	ifn-u937	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	respond	respond	VB	VB	_	13	acl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	red	red	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	platelets	platelet	NNS	NNS	_	24	conj	_	_
27	or	or	CC	CC	_	24	cc	_	_
28	granulocytes	granulocyte	NNS	NNS	_	24	conj	_	_
29	sensitized	sensitize	VBN	VBN	_	24	acl	_	_
30	with	with	IN	IN	_	31	case	_	_
31	sera	sera	NN	NN	_	29	nmod	_	_
32	from	from	IN	IN	_	34	case	_	_
33	pregnant	pregnant	JJ	JJ	_	34	amod	_	_
34	women	woman	NNS	NNS	_	31	nmod	_	_
35	whose	whose	WP$	WP$	_	36	nmod:poss	_	_
36	babies	baby	NNS	NNS	_	37	nsubj	_	_
37	had	have	VBD	VBD	_	34	acl:relcl	_	_
38	either	either	CC	CC	_	40	cc:preconj	_	_
39	haemolytic	haemolytic	JJ	JJ	_	40	amod	_	_
40	disease	disease	NN	NN	_	37	dobj	_	_
41	of	of	IN	IN	_	40	amod	_	_
42	the	the	DT	DT	_	40	det	_	_
43	newborn	newborn	JJ	JJ	_	40	amod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	HDN	hdn	NN	NN	_	40	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	,	,	,	,	_	40	punct	_	_
48	alloimmune	alloimmune	JJ	JJ	_	49	amod	_	_
49	thrombocytopenia	thrombocytopenia	NN	NN	_	40	conj	_	_
50	or	or	CC	CC	_	40	cc	_	_
51	alloimmune	alloimmune	JJ	JJ	_	52	amod	_	_
52	neutropenia	neutropenia	NN	NN	_	40	conj	_	_
53	respectively	respectively	RB	RB	_	37	advmod	_	_
54	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	monocytes	monocyte	NNS	NNS	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-U937	ifn-u937	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	conj	_	_
8	both	both	DT	DT	_	4	dep	_	_
9	responded	respond	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	red	red	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	sensitized	sensitize	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	antibodies	antibody	NNS	NNS	_	13	nmod	_	_
16	against	against	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	variety	variety	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	specificities	specificity	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	29	case	_	_
22	assumed	assume	VBN	VBN	_	29	amod	_	_
23	(	(	-LRB-	-LRB-	_	22	punct	_	_
24	although	although	IN	IN	_	22	dep	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	documented	document	VBN	VBN	_	22	dep	_	_
27	)	)	-RRB-	-RRB-	_	22	punct	_	_
28	clinical	clinical	JJ	JJ	_	29	amod	_	_
29	significance	significance	NN	NN	_	20	nmod	_	_
30	for	for	IN	IN	_	33	case	_	_
31	blood	blood	NN	NN	_	33	compound	_	_
32	transfusion	transfusion	NN	NN	_	33	compound	_	_
33	recipients	recipient	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	monocytes	monocyte	NNS	NNS	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-U937	ifn-u937	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	conj	_	_
8	responded	respond	VBD	VBD	_	0	root	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	weakly	weakly	RB	RB	_	8	advmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	red	red	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	sensitized	sensitize	VBN	VBN	_	13	acl	_	_
15	with	with	IN	IN	_	14	nmod	_	_
16	either	either	CC	CC	_	15	dep	_	_
17	anti-D	anti-d	JJ	JJ	_	15	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	sera	sera	NN	NN	_	17	nmod	_	_
20	from	from	IN	IN	_	21	case	_	_
21	mothers	mother	NNS	NNS	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	babies	baby	NNS	NNS	_	21	nmod	_	_
24	unaffected	unaffected	JJ	JJ	_	23	dep	_	_
25	by	by	IN	IN	_	26	case	_	_
26	HDN	hdn	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	15	punct	_	_
28	or	or	CC	CC	_	15	cc	_	_
29	with	with	IN	IN	_	30	case	_	_
30	antisera	antisera	NNS	NNS	_	15	conj	_	_
31	containing	contain	VBG	VBG	_	30	acl	_	_
32	high	high	JJ	JJ	_	34	amod	_	_
33	titre	titre	NN	NN	_	34	compound	_	_
34	antibodies	antibody	NNS	NNS	_	31	dobj	_	_
35	with	with	IN	IN	_	36	case	_	_
36	specificities	specificity	NNS	NNS	_	34	nmod	_	_
37	not	not	RB	RB	_	39	neg	_	_
38	normally	normally	RB	RB	_	39	advmod	_	_
39	associated	associate	VBN	VBN	_	36	acl	_	_
40	with	with	IN	IN	_	45	case	_	_
41	significantly	significantly	RB	RB	_	42	advmod	_	_
42	reduced	reduce	VBN	VBN	_	45	amod	_	_
43	red	red	JJ	JJ	_	45	amod	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	survival	survival	NN	NN	_	39	nmod	_	_
46	.	.	.	.	_	8	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Alu	alu	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cell-specific	cell-specific	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	gamma	gamma	NN	NN	_	14	compound	_	_
14	chain	chain	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	Fc	fc	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	16	conj	_	_
20	receptors	receptor	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Fc	fc	NN	NN	_	5	compound	_	_
3	epsilon	epsilon	NN	NN	_	5	compound	_	_
4	RI-gamma	ri-gamma	NN	NN	_	5	compound	_	_
5	chains	chain	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	where	where	WRB	WRB	_	16	advmod	_	_
15	they	they	PRP	PRP	_	16	nsubj	_	_
16	play	play	VBP	VBP	_	13	acl:relcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	critical	critical	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	signal	signal	NN	NN	_	22	compound	_	_
22	transduction	transduction	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	part	part	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	high	high	JJ	JJ	_	9	amod	_	_
7	affinity	affinity	NN	NN	_	9	compound	_	_
8	IgE	ige	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	mast	mast	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	basophils	basophil	NNS	NNS	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	Langerhans	langerhans	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	possibly	possibly	RB	RB	_	22	advmod	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	12	conj	_	_
23	;	;	:	:	_	3	punct	_	_
24	a	a	DT	DT	_	25	det	_	_
25	component	component	NN	NN	_	3	conj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	low	low	JJ	JJ	_	30	amod	_	_
29	affinity	affinity	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	25	nmod	_	_
31	for	for	IN	IN	_	32	case	_	_
32	IgG	igg	NN	NN	_	30	nmod	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	Fc	fc	NN	NN	_	36	compound	_	_
35	gamma	gamma	NN	NN	_	36	compound	_	_
36	RIIIA	riiia	NN	NN	_	32	dep	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	CD16	cd16	NN	NN	_	36	conj	_	_
39	)	)	-RRB-	-RRB-	_	36	punct	_	_
40	in	in	IN	IN	_	43	case	_	_
41	natural	natural	JJ	JJ	_	43	amod	_	_
42	killer	killer	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	25	nmod	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	macrophages	macrophage	NNS	NNS	_	43	conj	_	_
46	;	;	:	:	_	3	punct	_	_
47	and	and	CC	CC	_	3	cc	_	_
48	part	part	NN	NN	_	3	conj	_	_
49	of	of	IN	IN	_	54	case	_	_
50	the	the	DT	DT	_	54	det	_	_
51	T	t	NN	NN	_	54	compound	_	_
52	cell	cell	NN	NN	_	54	compound	_	_
53	antigen	antigen	NN	NN	_	54	compound	_	_
54	receptor	receptor	NN	NN	_	48	nmod	_	_
55	in	in	IN	IN	_	56	case	_	_
56	subsets	subset	NNS	NNS	_	48	nmod	_	_
57	of	of	IN	IN	_	59	case	_	_
58	T	t	NN	NN	_	59	compound	_	_
59	cells	cell	NNS	NNS	_	56	nmod	_	_
60	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	gamma	gamma	NN	NN	_	12	compound	_	_
11	chain	chain	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	analyzing	analyze	VBG	VBG	_	4	advcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	2.5-kilobase	2.5-kilobase	JJ	JJ	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	14	dobj	_	_
18	upstream	upstream	JJ	JJ	_	17	advmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	start	start	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	3	dobj	_	_
6	specific	specific	JJ	JJ	_	5	amod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	cells	cell	NNS	NNS	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
11	lineage	lineage	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tissue	tissue	NN	NN	_	5	compound	_	_
5	specificity	specificity	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	promoter	promoter	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	only	only	RB	RB	_	11	advmod	_	_
11	partial	partial	JJ	JJ	_	0	root	_	_
12	because	because	IN	IN	_	15	mark	_	_
13	it	it	PRP	PRP	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	active	active	JJ	JJ	_	11	advcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	all	all	DT	DT	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	hematopoietic	hematopoietic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	tested	test	VBN	VBN	_	21	acl	_	_
23	here	here	RB	RB	_	22	advmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	regardless	regardless	RB	RB	_	15	advmod	_	_
26	of	of	IN	IN	_	30	mark	_	_
27	whether	whether	IN	IN	_	30	mark	_	_
28	they	they	PRP	PRP	_	30	nsubj	_	_
29	constitutively	constitutively	RB	RB	_	30	advmod	_	_
30	express	express	VBP	VBP	_	25	advcl	_	_
31	Fc	fc	NN	NN	_	35	compound	_	_
32	epsilon	epsilon	NN	NN	_	35	compound	_	_
33	RI-gamma	ri-gamma	NN	NN	_	35	compound	_	_
34	chain	chain	NN	NN	_	35	compound	_	_
35	transcripts	transcript	NNS	NNS	_	30	dobj	_	_
36	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	two	two	CD	CD	_	8	nummod	_	_
5	adjacent	adjacent	JJ	JJ	_	8	amod	_	_
6	cis-acting	cis-acting	JJ	JJ	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	elements	element	NNS	NNS	_	3	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	both	both	DT	DT	_	14	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	10	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	part	part	NN	NN	_	8	acl:relcl	_	_
15	of	of	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	Alu	alu	NN	NN	_	18	compound	_	_
18	repeat	repeat	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	first	first	JJ	JJ	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	-445/-366	-445/-366	CD	CD	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	positive	positive	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	0	root	_	_
10	active	active	JJ	JJ	_	9	amod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	basophils	basophil	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	second	second	JJ	JJ	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	-365/-264	-365/-264	CD	CD	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	binds	bind	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	appear	appear	VBP	VBP	_	9	acl:relcl	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	different	different	JJ	JJ	_	12	xcomp	_	_
16	in	in	IN	IN	_	17	case	_	_
17	basophils	basophil	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	,	,	,	,	_	6	punct	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	acts	act	VBZ	VBZ	_	6	conj	_	_
24	as	as	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	negative	negative	JJ	JJ	_	27	amod	_	_
27	element	element	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	basophils	basophil	NNS	NNS	_	23	nmod	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	as	as	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	positive	positive	JJ	JJ	_	34	amod	_	_
34	one	one	NN	NN	_	23	conj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	Alu	alu	NN	NN	_	5	compound	_	_
5	repeat	repeat	NN	NN	_	16	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	5	punct	_	_
7	90	90	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	9	nmod:npmod	_	_
9	identical	identical	JJ	JJ	_	5	amod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	Alu	alu	NN	NN	_	13	compound	_	_
12	consensus	consensus	NN	NN	_	13	compound	_	_
13	sequences	sequence	NNS	NNS	_	9	nmod	_	_
14	)	)	-RRB-	-RRB-	_	5	punct	_	_
15	has	have	VBZ	VBZ	_	16	aux	_	_
16	evolved	evolve	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	become	become	VB	VB	_	16	xcomp	_	_
19	both	both	CC	CC	_	24	dep	_	_
20	a	a	DT	DT	_	24	det	_	_
21	positive	positive	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	negative	negative	JJ	JJ	_	21	conj	_	_
24	regulator	regulator	NN	NN	_	18	xcomp	_	_
25	.	.	.	.	_	16	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	compound	_	_
3	viruses	virus	NNS	NNS	_	9	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	heterologous	heterologous	JJ	JJ	_	6	amod	_	_
6	enhancer/promoters	enhancer/promoters	NNS	NNS	_	4	dobj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	replication	replication	NN	NN	_	9	nmod:npmod	_	_
9	competent	competent	JJ	JJ	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	exhibit	exhibit	VBP	VBP	_	9	conj	_	_
12	different	different	JJ	JJ	_	14	amod	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	tropisms	tropism	NNS	NNS	_	11	dobj	_	_
15	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
4	virus	virus	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIV	hiv	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	type	type	NN	NN	_	16	nsubj	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	long	long	JJ	JJ	_	12	amod	_	_
11	terminal	terminal	JJ	JJ	_	12	amod	_	_
12	repeat	repeat	NN	NN	_	8	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LTR	ltr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	contains	contain	VBZ	VBZ	_	0	root	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	16	dobj	_	_
19	for	for	IN	IN	_	23	case	_	_
20	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
21	factor	factor	NN	NN	_	23	compound	_	_
22	kappa	kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	the	the	DT	DT	_	34	det	_	_
30	constitutively	constitutively	RB	RB	_	31	advmod	_	_
31	expressed	express	VBN	VBN	_	34	amod	_	_
32	transcription	transcription	NN	NN	_	34	compound	_	_
33	factor	factor	NN	NN	_	34	compound	_	_
34	Sp1	sp1	NN	NN	_	23	conj	_	_
35	,	,	,	,	_	23	punct	_	_
36	both	both	DT	DT	_	41	nsubjpass	_	_
37	of	of	IN	IN	_	38	case	_	_
38	which	which	WDT	WDT	_	36	nmod	_	_
39	are	be	VBP	VBP	_	41	auxpass	_	_
40	highly	highly	RB	RB	_	41	advmod	_	_
41	conserved	conserve	VBN	VBN	_	23	acl:relcl	_	_
42	in	in	IN	IN	_	48	case	_	_
43	HIV	hiv	NN	NN	_	48	compound	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	simian	simian	JJ	JJ	_	47	amod	_	_
46	immunodeficiency	immunodeficiency	NN	NN	_	47	compound	_	_
47	virus	virus	NN	NN	_	43	conj	_	_
48	isolates	isolate	NNS	NNS	_	41	nmod	_	_
49	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	delineate	delineate	VB	VB	_	30	ccomp	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	motifs	motif	NNS	NNS	_	4	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	replicative	replicative	JJ	JJ	_	11	amod	_	_
11	capacity	capacity	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HIV	hiv	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	2	cc	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	explore	explore	VB	VB	_	2	conj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	possibility	possibility	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	mark	_	_
20	extending	extend	VBG	VBG	_	18	acl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	virus	virus	NN	NN	_	24	compound	_	_
23	host	host	NN	NN	_	24	compound	_	_
24	range	range	NN	NN	_	20	dobj	_	_
25	,	,	,	,	_	30	punct	_	_
26	known	know	VBN	VBN	_	28	amod	_	_
27	heterologous	heterologous	JJ	JJ	_	28	amod	_	_
28	enhancer/promoters	enhancer/promoters	NNS	NNS	_	30	nsubjpass	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	inserted	insert	VBN	VBN	_	0	root	_	_
31	into	into	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	HIV-1	hiv-1	NN	NN	_	34	compound	_	_
34	LTR	ltr	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	44	case	_	_
36	place	place	NN	NN	_	44	dep	_	_
37	of	of	IN	IN	_	44	case	_	_
38	the	the	DT	DT	_	44	det	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	44	compound	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	Sp1	sp1	NN	NN	_	40	conj	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	sites	site	NNS	NNS	_	30	nmod	_	_
45	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	28	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	substitutions	substitution	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	viral	viral	JJ	JJ	_	8	amod	_	_
8	replication	replication	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	transfected	transfect	VBN	VBN	_	12	amod	_	_
11	HeLa	hela	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	on	on	IN	IN	_	16	case	_	_
15	HIV	hiv	NN	NN	_	16	compound	_	_
16	infection	infection	NN	NN	_	8	conj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	continuous	continuous	JJ	JJ	_	26	amod	_	_
24	T-leukemia	t-leukemia	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	21	conj	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	evaluated	evaluate	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	HIVs	hivs	NN	NN	_	21	nsubjpass	_	_
2	in	in	IN	IN	_	3	case	_	_
3	which	which	WDT	WDT	_	15	nmod	_	_
4	the	the	DT	DT	_	8	det	_	_
5	NF-	nf-	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B/Sp1	b/sp1	NN	NN	_	8	compound	_	_
8	enhancer	enhancer	NN	NN	_	15	nsubjpass	_	_
9	plus	plus	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	13	det	_	_
11	downstream	downstream	JJ	JJ	_	13	amod	_	_
12	TATA	tata	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	8	conj	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	replaced	replace	VBN	VBN	_	1	acl:relcl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	heterologous	heterologous	JJ	JJ	_	18	amod	_	_
18	enhancer/promoters	enhancer/promoters	NNS	NNS	_	15	nmod	_	_
19	were	be	VBD	VBD	_	21	auxpass	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	constructed	construct	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	Viruses	virus	NNS	NNS	_	8	nsubj	_	_
2	containing	contain	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	cytomegalovirus	cytomegalovirus	NN	NN	_	7	compound	_	_
6	immediate-early	immediate-early	JJ	JJ	_	7	amod	_	_
7	enhancer	enhancer	NN	NN	_	2	dobj	_	_
8	exhibited	exhibit	VBD	VBD	_	0	root	_	_
9	infectious	infectious	JJ	JJ	_	10	amod	_	_
10	kinetics	kinetics	NNS	NNS	_	8	dobj	_	_
11	similar	similar	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	that	that	DT	DT	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	wild-type	wild-type	JJ	JJ	_	16	amod	_	_
16	HIV	hiv	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	activated	activate	VBN	VBN	_	22	amod	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	AA2	aa2	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	conj	_	_
26	but	but	CC	CC	_	8	cc	_	_
27	replicated	replicate	VBD	VBD	_	8	conj	_	_
28	less	less	RBR	RBR	_	29	advmod	_	_
29	efficiently	efficiently	RB	RB	_	27	advmod	_	_
30	in	in	IN	IN	_	34	case	_	_
31	H9	h9	NN	NN	_	34	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	CEM	cem	NN	NN	_	31	conj	_	_
34	cells	cell	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	heterologous	heterologous	JJ	JJ	_	7	amod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	elements	element	NNS	NNS	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	capable	capable	JJ	JJ	_	3	ccomp	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	restoring	restore	VBG	VBG	_	9	advcl	_	_
12	Tat	tat	NN	NN	_	13	compound	_	_
13	responsiveness	responsiveness	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HIV	hiv	NN	NN	_	17	compound	_	_
17	LTR	ltr	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	dep	_	_
20	context	context	NN	NN	_	22	dep	_	_
21	of	of	IN	IN	_	22	mark	_	_
22	directing	direct	VBG	VBG	_	11	nmod	_	_
23	reporter	reporter	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	as	as	RB	RB	_	22	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	production	production	NN	NN	_	22	conj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	infectious	infectious	JJ	JJ	_	35	amod	_	_
34	progeny	progeny	NN	NN	_	35	compound	_	_
35	virions	virion	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	mandatory	mandatory	JJ	JJ	_	7	amod	_	_
6	proximal	proximal	JJ	JJ	_	7	amod	_	_
7	step	step	NN	NN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	radiation-induced	radiation-induced	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	protein	protein	NN	NN	_	17	compound	_	_
14	kinase	kinase	NN	NN	_	17	compound	_	_
15	C	c	NN	NN	_	17	compound	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	10	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	B-	b-	NN	NN	_	22	compound	_	_
21	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
22	precursors	precursor	NNS	NNS	_	10	nmod	_	_
23	-LSB-	-lsb-	-LRB-	-LRB-	_	26	punct	_	_
24	published	publish	VBN	VBN	_	25	amod	_	_
25	erratum	erratum	NN	NN	_	26	nsubj	_	_
26	appears	appear	VBZ	VBZ	_	7	parataxis	_	_
27	in	in	IN	IN	_	34	case	_	_
28	Proc	Proc	NNP	NNP	_	34	compound	_	_
29	Natl	Natl	NNP	NNP	_	34	compound	_	_
30	Acad	Acad	NNP	NNP	_	34	compound	_	_
31	Sci	Sci	NNP	NNP	_	34	compound	_	_
32	U	U	NNP	NNP	_	34	compound	_	_
33	S	S	NNP	NNP	_	34	compound	_	_
34	A	A	NNP	NNP	_	26	nmod	_	_
35	1993	1993	CD	CD	_	36	nummod	_	_
36	Apr	Apr	NNP	NNP	_	34	dep	_	_
37	15	15	CD	CD	_	36	nummod	_	_
38	;	;	:	:	_	34	punct	_	_
39	90	90	CD	CD	_	44	nummod	_	_
40	(	(	-LRB-	-LRB-	_	44	punct	_	_
41	8	8	CD	CD	_	44	nummod	_	_
42	)	)	-RRB-	-RRB-	_	44	punct	_	_
43	:	:	:	:	_	44	punct	_	_
44	3775	3775	CD	CD	_	34	dep	_	_
45	-RSB-	-rsb-	-RRB-	-RRB-	_	26	punct	_	_

1	Ionizing	ionize	VBG	VBG	_	2	amod	_	_
2	radiation	radiation	NN	NN	_	3	nsubj	_	_
3	triggers	trigger	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	signal	signal	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	B-lymphocyte	b-lymphocyte	NN	NN	_	9	compound	_	_
9	precursors	precursor	NNS	NNS	_	5	nmod	_	_
10	that	that	WDT	WDT	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	intimately	intimately	RB	RB	_	13	advmod	_	_
13	linked	link	VBN	VBN	_	5	acl:relcl	_	_
14	to	to	TO	TO	_	20	case	_	_
15	an	a	DT	DT	_	20	det	_	_
16	active	active	JJ	JJ	_	20	amod	_	_
17	protein-tyrosine	protein-tyrosine	NN	NN	_	20	compound	_	_
18	kinase	kinase	NN	NN	_	20	compound	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	pathway	pathway	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	B-lymphocyte	b-lymphocyte	NN	NN	_	6	compound	_	_
6	precursors	precursor	NNS	NNS	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	irradiation	irradiation	NN	NN	_	11	nsubj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	gamma-rays	gamma-ray	NNS	NNS	_	8	nmod	_	_
11	leads	lead	VBZ	VBZ	_	2	ccomp	_	_
12	to	to	TO	TO	_	16	case	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	i	i	LS	LS	_	16	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	stimulation	stimulation	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	phosphatidylinositol	phosphatidylinositol	NN	NN	_	19	compound	_	_
19	turnover	turnover	NN	NN	_	16	nmod	_	_
20	;	;	:	:	_	16	punct	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	ii	ii	LS	LS	_	25	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	downstream	downstream	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	16	conj	_	_
26	by	by	IN	IN	_	28	case	_	_
27	covalent	covalent	JJ	JJ	_	28	amod	_	_
28	modification	modification	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	multiple	multiple	JJ	JJ	_	33	amod	_	_
31	serine-specific	serine-specific	JJ	JJ	_	33	amod	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	kinases	kinase	NNS	NNS	_	28	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	including	include	VBG	VBG	_	38	case	_	_
36	protein	protein	NN	NN	_	38	compound	_	_
37	kinase	kinase	NN	NN	_	38	compound	_	_
38	C	c	NN	NN	_	33	nmod	_	_
39	;	;	:	:	_	16	punct	_	_
40	and	and	CC	CC	_	16	cc	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	iii	iii	LS	LS	_	44	dep	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	activation	activation	NN	NN	_	16	conj	_	_
45	of	of	IN	IN	_	49	case	_	_
46	nuclear	nuclear	JJ	JJ	_	49	amod	_	_
47	factor	factor	NN	NN	_	49	compound	_	_
48	kappa	kappa	NN	NN	_	49	compound	_	_
49	B	b	NN	NN	_	44	nmod	_	_
50	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	radiation-induced	radiation-induced	JJ	JJ	_	5	amod	_	_
5	signals	signal	NNS	NNS	_	1	nmod	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	effectively	effectively	RB	RB	_	8	advmod	_	_
8	prevented	prevent	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	protein-tyrosine	protein-tyrosine	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	inhibitors	inhibitor	NNS	NNS	_	8	nmod	_	_
14	genistein	genistein	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	herbimycin	herbimycin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	12	nsubj	_	_
5	is	be	VBZ	VBZ	_	12	cop	_	_
6	an	a	DT	DT	_	12	det	_	_
7	important	important	JJ	JJ	_	12	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	perhaps	perhaps	RB	RB	_	10	advmod	_	_
10	mandatory	mandatory	JJ	JJ	_	7	conj	_	_
11	proximal	proximal	JJ	JJ	_	12	amod	_	_
12	step	step	NN	NN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	protein	protein	NN	NN	_	22	compound	_	_
19	kinase	kinase	NN	NN	_	22	compound	_	_
20	C	c	NN	NN	_	22	compound	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	cascade	cascade	NN	NN	_	15	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	B-lymphocyte	b-lymphocyte	NN	NN	_	26	compound	_	_
26	precursors	precursor	NNS	NNS	_	15	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nsubj	_	_
2	report	report	VBP	VBP	_	1	dep	_	_
3	expands	expand	NNS	NNS	_	0	root	_	_
4	current	current	JJ	JJ	_	5	amod	_	_
5	knowledge	knowledge	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	radiation-induced	radiation-induced	JJ	JJ	_	10	amod	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	cascade	cascade	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	clarifying	clarify	VBG	VBG	_	3	advcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	chronological	chronological	JJ	JJ	_	15	amod	_	_
15	sequence	sequence	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	biochemical	biochemical	JJ	JJ	_	18	amod	_	_
18	events	event	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	follow	follow	VBP	VBP	_	18	acl:relcl	_	_
21	irradiation	irradiation	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Photoaffinity	photoaffinity	NN	NN	_	2	compound	_	_
2	labeling	labeling	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	plasma	plasma	NN	NN	_	6	compound	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	2	nmod	_	_
7	for	for	IN	IN	_	8	case	_	_
8	aldosterone	aldosterone	NN	NN	_	6	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Non-genomic	non-genomic	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	sodium-proton-antiport	sodium-proton-antiport	NN	NN	_	2	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
15	which	which	WDT	WDT	_	18	nsubj	_	_
16	could	could	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	related	related	JJ	JJ	_	14	acl:relcl	_	_
19	to	to	TO	TO	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	new	new	JJ	JJ	_	24	amod	_	_
22	aldosterone	aldosterone	NN	NN	_	24	compound	_	_
23	membrane	membrane	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	paper	paper	NN	NN	_	13	nmod	_	_
5	plasma	plasma	NN	NN	_	6	compound	_	_
6	membranes	membrane	NNS	NNS	_	13	nsubjpass	_	_
7	from	from	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	covalently	covalently	RB	RB	_	13	advmod	_	_
13	photolabeled	photolabele	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	-LSB-125I-RSB--aldosterone	-lsb-125i-rsb--aldosterone	NN	NN	_	17	compound	_	_
17	derivative	derivative	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Sodium	sodium	NN	NN	_	3	nmod:npmod	_	_
2	dodecyl	dodecyl	NN	NN	_	3	nmod:npmod	_	_
3	sulfate-polyacrylamide	sulfate-polyacrylamide	JJ	JJ	_	5	amod	_	_
4	gel	gel	NN	NN	_	5	compound	_	_
5	electrophoresis	electrophoresis	NN	NN	_	6	nsubj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	significant	significant	JJ	JJ	_	9	amod	_	_
8	aldosterone	aldosterone	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	6	dobj	_	_
10	at	at	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	weight	weight	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	approximately	approximately	RB	RB	_	16	advmod	_	_
16	50000	50000	CD	CD	_	17	nummod	_	_
17	Dalton	dalton	NN	NN	_	13	nmod	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	absent	absent	JJ	JJ	_	6	dep	_	_
21	with	with	IN	IN	_	23	case	_	_
22	1	1	CD	CD	_	23	nummod	_	_
23	microM	microm	NN	NN	_	20	nmod	_	_
24	cold	cold	JJ	JJ	_	25	amod	_	_
25	aldosterone	aldosterone	NN	NN	_	23	dep	_	_
26	,	,	,	,	_	23	punct	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	23	cc	_	_
29	cortisol	cortisol	NN	NN	_	23	conj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	binding	bind	VBG	VBG	_	33	amod	_	_
33	media	media	NNS	NNS	_	23	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	sulfhydryl	sulfhydryl	NN	NN	_	7	compound	_	_
6	agent	agent	NN	NN	_	7	compound	_	_
7	dithiothreitol	dithiothreitol	NN	NN	_	2	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affect	affect	VB	VB	_	0	root	_	_
11	results	result	NNS	NNS	_	10	dobj	_	_
12	suggesting	suggest	VBG	VBG	_	11	acl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	absence	absence	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	disulfide	disulfide	NN	NN	_	17	compound	_	_
17	bridges	bridge	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	steroid	steroid	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	domain	domain	NN	NN	_	14	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	receptor	receptor	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	define	define	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	weight	weight	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	aldosterone	aldosterone	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Alpha-lipoic	alpha-lipoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	inhibitor	inhibitor	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Acquired	acquire	VBN	VBN	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	compound	_	_
3	syndrome	syndrome	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	AIDS	aids	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	results	result	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	infection	infection	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	14	compound	_	_
14	virus	virus	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HIV	hiv	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	long	long	JJ	JJ	_	4	amod	_	_
3	terminal	terminal	JJ	JJ	_	4	amod	_	_
4	repeat	repeat	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LTR	ltr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	region	region	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	HIV	hiv	NN	NN	_	12	compound	_	_
11	proviral	proviral	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	8	nmod	_	_
13	contains	contain	VBZ	VBZ	_	0	root	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	20	case	_	_
17	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
18	factor	factor	NN	NN	_	20	compound	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	13	punct	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	this	this	DT	DT	_	29	det	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activator	activator	NN	NN	_	30	nsubj	_	_
30	appears	appear	VBZ	VBZ	_	13	conj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	regulate	regulate	VB	VB	_	30	xcomp	_	_
33	HIV	hiv	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	13	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	reactive	reactive	JJ	JJ	_	9	amod	_	_
8	oxygen	oxygen	NN	NN	_	9	compound	_	_
9	species	species	NNS	NNS	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ROS	ros	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	16	case	_	_
14	signal	signal	NN	NN	_	16	compound	_	_
15	transduction	transduction	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	5	nmod	_	_
17	leading	lead	VBG	VBG	_	16	acl	_	_
18	to	to	TO	TO	_	21	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	based	base	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	reports	report	NNS	NNS	_	5	nmod	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	antioxidants	antioxidant	NNS	NNS	_	14	nsubj	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	eliminate	eliminate	VBP	VBP	_	9	acl:relcl	_	_
12	ROS	ros	NN	NN	_	11	dobj	_	_
13	should	should	MD	MD	_	14	aux	_	_
14	block	block	VB	VB	_	7	ccomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activation	activation	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	subsequently	subsequently	RB	RB	_	23	advmod	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	14	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	thus	thus	RB	RB	_	14	advmod	_	_
27	antioxidants	antioxidant	NNS	NNS	_	30	nsubjpass	_	_
28	can	can	MD	MD	_	30	aux	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	used	use	VBN	VBN	_	14	dep	_	_
31	as	as	IN	IN	_	33	case	_	_
32	therapeutic	therapeutic	JJ	JJ	_	33	amod	_	_
33	agents	agent	NNS	NNS	_	30	nmod	_	_
34	for	for	IN	IN	_	35	case	_	_
35	AIDS	aids	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Incubation	incubation	NN	NN	_	28	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Jurkat	jurkat	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	1	1	CD	CD	_	10	nummod	_	_
8	x	x	CC	CC	_	7	cc	_	_
9	10(6)	10(6)	CD	CD	_	7	conj	_	_
10	cells/ml	cells/ml	NNS	NNS	_	5	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	with	with	IN	IN	_	19	case	_	_
13	a	a	DT	DT	_	19	det	_	_
14	natural	natural	JJ	JJ	_	19	amod	_	_
15	thiol	thiol	NN	NN	_	19	compound	_	_
16	antioxidant	antioxidant	NN	NN	_	19	amod	_	_
17	,	,	,	,	_	16	punct	_	_
18	alpha-lipoic	alpha-lipoic	JJ	JJ	_	16	dep	_	_
19	acid	acid	NN	NN	_	1	nmod	_	_
20	,	,	,	,	_	1	punct	_	_
21	prior	prior	JJ	JJ	_	24	case	_	_
22	to	to	TO	TO	_	21	mwe	_	_
23	the	the	DT	DT	_	24	det	_	_
24	stimulation	stimulation	NN	NN	_	1	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	cells	cell	NNS	NNS	_	24	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	found	find	VBN	VBN	_	0	root	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	inhibit	inhibit	VB	VB	_	28	xcomp	_	_
31	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	30	dobj	_	_
34	induced	induce	VBN	VBN	_	33	acl	_	_
35	by	by	IN	IN	_	38	case	_	_
36	tumor	tumor	NN	NN	_	38	compound	_	_
37	necrosis	necrosis	NN	NN	_	38	compound	_	_
38	factor-alpha	factor-alpha	NN	NN	_	34	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	25	25	CD	CD	_	41	nummod	_	_
41	ng/ml	ng/ml	NN	NN	_	38	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	or	or	CC	CC	_	38	cc	_	_
44	by	by	IN	IN	_	47	case	_	_
45	phorbol	phorbol	NN	NN	_	47	compound	_	_
46	12-myristate	12-myristate	NN	NN	_	47	compound	_	_
47	13-acetate	13-acetate	NN	NN	_	38	conj	_	_
48	(	(	-LRB-	-LRB-	_	50	punct	_	_
49	50	50	CD	CD	_	50	nummod	_	_
50	ng/ml	ng/ml	NN	NN	_	47	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	action	action	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	alpha-lipoic	alpha-lipoic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	very	very	RB	RB	_	12	advmod	_	_
12	potent	potent	JJ	JJ	_	8	xcomp	_	_
13	as	as	IN	IN	_	18	mark	_	_
14	only	only	RB	RB	_	15	advmod	_	_
15	4	4	CD	CD	_	16	nummod	_	_
16	mM	mm	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	needed	need	VBN	VBN	_	12	advcl	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	complete	complete	JJ	JJ	_	22	amod	_	_
22	inhibition	inhibition	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	8	punct	_	_
24	whereas	whereas	IN	IN	_	8	dep	_	_
25	20	20	CD	CD	_	26	nummod	_	_
26	mM	mm	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	required	require	VBN	VBN	_	8	parataxis	_	_
29	for	for	IN	IN	_	30	case	_	_
30	N-acetylcysteine	n-acetylcysteine	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	alpha-lipoic	alpha-lipoic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	9	nsubj	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	cop	_	_
9	effective	effective	JJ	JJ	_	3	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	AIDS	aids	NN	NN	_	12	compound	_	_
12	therapeutics	therapeutics	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	putative	putative	JJ	JJ	_	7	amod	_	_
4	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
5	G0/G1	g0/g1	NN	NN	_	7	compound	_	_
6	switch	switch	VBP	VBP	_	7	dep	_	_
7	gene	gene	NN	NN	_	0	root	_	_
8	homologous	homologous	JJ	JJ	_	7	amod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	rodent	rodent	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	encoding	encode	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	18	det	_	_
15	zinc-binding	zinc-binding	JJ	JJ	_	18	amod	_	_
16	potential	potential	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	G0S24	g0s24	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	member	member	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	set	set	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	genes	gene	NNS	NNS	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	putative	putative	JJ	JJ	_	15	amod	_	_
12	G0/G1	g0/g1	NN	NN	_	15	compound	_	_
13	switch	switch	NN	NN	_	15	compound	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	expressed	express	VBN	VBN	_	9	acl:relcl	_	_
20	transiently	transiently	RB	RB	_	19	advmod	_	_
21	within	within	IN	IN	_	23	case	_	_
22	1-2	1-2	CD	CD	_	23	nummod	_	_
23	hr	hr	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	addition	addition	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	lectin	lectin	NN	NN	_	26	nmod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	cycloheximide	cycloheximide	NN	NN	_	28	conj	_	_
31	to	to	TO	TO	_	35	case	_	_
32	human	human	JJ	JJ	_	35	amod	_	_
33	blood	blood	NN	NN	_	35	compound	_	_
34	mononuclear	mononuclear	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	26	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	full-length	full-length	JJ	JJ	_	6	amod	_	_
5	cDNA	cdna	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	corresponding	corresponding	JJ	JJ	_	11	amod	_	_
10	genomic	genomic	JJ	JJ	_	11	amod	_	_
11	sequence	sequence	NN	NN	_	1	nmod	_	_
12	reveals	reveal	VBZ	VBZ	_	0	root	_	_
13	an	a	DT	DT	_	16	det	_	_
14	open	open	JJ	JJ	_	16	amod	_	_
15	reading	reading	NN	NN	_	16	compound	_	_
16	frame	frame	NN	NN	_	12	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	326	326	CD	CD	_	20	nummod	_	_
19	amino	amino	NN	NN	_	20	compound	_	_
20	acids	acid	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	distributed	distribute	VBN	VBN	_	16	acl	_	_
23	across	across	IN	IN	_	25	case	_	_
24	two	two	CD	CD	_	25	nummod	_	_
25	exons	exon	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	Potential	potential	JJ	JJ	_	3	amod	_	_
2	phosphorylation	phosphorylation	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	4	nsubj	_	_
4	include	include	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	PSPTSPT	psptspt	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	resembles	resemble	VBZ	VBZ	_	7	acl:relcl	_	_
11	an	a	DT	DT	_	15	det	_	_
12	RNA	rna	NN	NN	_	15	compound	_	_
13	polymerase	polymerase	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	repeat	repeat	NN	NN	_	10	xcomp	_	_
16	reported	report	VBN	VBN	_	15	acl	_	_
17	to	to	TO	TO	_	20	mark	_	_
18	be	be	VB	VB	_	20	cop	_	_
19	a	a	DT	DT	_	20	det	_	_
20	target	target	NN	NN	_	16	xcomp	_	_
21	of	of	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	cell	cell	NN	NN	_	27	compound	_	_
24	cycle	cycle	NN	NN	_	27	compound	_	_
25	control	control	NN	NN	_	27	compound	_	_
26	kinase	kinase	NN	NN	_	27	compound	_	_
27	cdc2	cdc2	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	derived	derive	VBN	VBN	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	those	those	DT	DT	_	1	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	rodent	rodent	JJ	JJ	_	11	amod	_	_
11	homologs	homolog	NNS	NNS	_	8	nmod	_	_
12	allows	allow	VBZ	VBZ	_	0	root	_	_
13	classification	classification	NN	NN	_	12	dobj	_	_
14	into	into	IN	IN	_	16	case	_	_
15	three	three	CD	CD	_	16	nummod	_	_
16	groups	group	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Group	group	NN	NN	_	3	nsubj	_	_
2	1	1	CD	CD	_	1	nummod	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	G0S24	g0s24	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	11	det	_	_
7	rat	rat	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	mouse	mouse	NN	NN	_	7	conj	_	_
10	TIS11	tis11	NN	NN	_	11	compound	_	_
11	genes	gene	NNS	NNS	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	11	punct	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	known	know	VBN	VBN	_	11	acl	_	_
15	as	as	IN	IN	_	16	case	_	_
16	TTP	ttp	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	Nup475	nup475	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	Zfp36	zfp36	NN	NN	_	16	conj	_	_
22	)	)	-RRB-	-RRB-	_	11	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	Members	member	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	group	group	NN	NN	_	1	nmod	_	_
5	have	have	VBP	VBP	_	0	root	_	_
6	three	three	CD	CD	_	8	nummod	_	_
7	tetraproline	tetraproline	JJ	JJ	_	8	amod	_	_
8	repeats	repeat	NNS	NNS	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Groups	group	NNS	NNS	_	5	nsubj	_	_
2	1	1	CD	CD	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	2	2	CD	CD	_	2	conj	_	_
5	have	have	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	serine-rich	serine-rich	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	an	a	DT	DT	_	13	det	_	_
11	``	``	``	``	_	13	punct	_	_
12	arginine	arginine	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	RRLPIF	rrlpif	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	carboxyl	carboxyl	NN	NN	_	20	compound	_	_
20	terminus	terminus	NN	NN	_	5	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	groups	group	NNS	NNS	_	3	nsubj	_	_
3	contain	contain	VBP	VBP	_	0	root	_	_
4	cysteine-	cysteine-	NN	NN	_	10	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	histidine-rich	histidine-rich	JJ	JJ	_	4	conj	_	_
7	putative	putative	JJ	JJ	_	10	amod	_	_
8	zinc	zinc	NN	NN	_	10	compound	_	_
9	finger	finger	NN	NN	_	10	compound	_	_
10	domains	domain	NNS	NNS	_	3	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	a	a	DT	DT	_	16	det	_	_
13	serine-phenylalanine	serine-phenylalanine	JJ	JJ	_	16	amod	_	_
14	``	``	``	``	_	16	punct	_	_
15	SFS	sf	NNS	NNS	_	16	compound	_	_
16	domain	domain	NN	NN	_	10	conj	_	_
17	similar	similar	JJ	JJ	_	16	amod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	part	part	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	large	large	JJ	JJ	_	23	amod	_	_
23	subunit	subunit	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	eukaryotic	eukaryotic	JJ	JJ	_	27	amod	_	_
26	RNA	rna	NN	NN	_	27	compound	_	_
27	polymerase	polymerase	NN	NN	_	23	nmod	_	_
28	II	ii	CD	CD	_	27	nummod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Comparison	comparison	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	group	group	NN	NN	_	9	compound	_	_
4	1	1	CD	CD	_	9	nummod	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	mouse	mouse	NN	NN	_	5	conj	_	_
8	genomic	genomic	JJ	JJ	_	9	amod	_	_
9	sequences	sequence	NNS	NNS	_	1	nmod	_	_
10	shows	show	VBZ	VBZ	_	0	root	_	_
11	high	high	JJ	JJ	_	12	amod	_	_
12	conservation	conservation	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	5'	5'	JJ	JJ	_	16	amod	_	_
16	flank	flank	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	exons	exon	NNS	NNS	_	16	conj	_	_
19	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	CpG	cpg	NN	NN	_	3	compound	_	_
3	island	island	NN	NN	_	4	nsubj	_	_
4	suggests	suggest	VBZ	VBZ	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	germ	germ	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	G0S24	g0s24	NN	NN	_	2	nsubj	_	_
2	has	have	VBZ	VBZ	_	0	root	_	_
3	potential	potential	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	5'	5'	JJ	JJ	_	11	amod	_	_
11	flank	flank	NN	NN	_	2	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	intron	intron	NN	NN	_	11	conj	_	_
14	;	;	:	:	_	2	punct	_	_
15	these	these	DT	DT	_	16	nsubj	_	_
16	include	include	VBP	VBP	_	2	parataxis	_	_
17	a	a	DT	DT	_	20	det	_	_
18	serum	serum	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	16	punct	_	_

1	Protein	protein	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	genomic	genomic	JJ	JJ	_	1	conj	_	_
4	sequences	sequence	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	similarities	similarity	NNS	NNS	_	5	dobj	_	_
7	with	with	IN	IN	_	8	case	_	_
8	those	those	DT	DT	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	proteins	protein	NNS	NNS	_	11	nmod	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	transcription	transcription	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	G0S24	g0s24	NN	NN	_	22	compound	_	_
22	product	product	NN	NN	_	23	nsubj	_	_
23	has	have	VBZ	VBZ	_	18	ccomp	_	_
24	a	a	DT	DT	_	26	det	_	_
25	similar	similar	JJ	JJ	_	26	amod	_	_
26	role	role	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	c-jun	c-jun	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	c-fos	c-fos	NN	NN	_	7	conj	_	_
10	messenger	messenger	NN	NN	_	11	compound	_	_
11	RNA	rna	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	activator	activator	NN	NN	_	16	compound	_	_
14	protein-1	protein-1	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	5	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	interleukin-4	interleukin-4	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-4	il-4	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	on	on	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	lipopolysaccharide	lipopolysaccharide	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LPS	lps	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	induction	induction	NN	NN	_	4	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	immediate	immediate	JJ	JJ	_	21	amod	_	_
20	early	early	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	16	nmod	_	_
22	c-fos	c-fos	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	c-jun	c-jun	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	3	nsubj	_	_
3	encode	encode	VBP	VBP	_	0	root	_	_
4	proteins	protein	NNS	NNS	_	3	dobj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	form	form	VBP	VBP	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	11	det	_	_
8	dimeric	dimeric	JJ	JJ	_	11	amod	_	_
9	complex	complex	NN	NN	_	11	compound	_	_
10	activator	activator	NN	NN	_	11	compound	_	_
11	protein-1	protein-1	NN	NN	_	6	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AP-1	ap-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	active	active	JJ	JJ	_	11	acl:relcl	_	_
19	as	as	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Maximal	maximal	JJ	JJ	_	2	amod	_	_
2	accumulation	accumulation	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	either	either	CC	CC	_	5	cc:preconj	_	_
5	c-fos	c-fos	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-jun	c-jun	NN	NN	_	5	conj	_	_
8	messenger	messenger	NN	NN	_	9	compound	_	_
9	RNA	rna	NN	NN	_	5	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	mRNA	mrna	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	occurred	occur	VBD	VBD	_	0	root	_	_
14	30	30	CD	CD	_	15	nummod	_	_
15	minutes	minute	NNS	NNS	_	13	nmod	_	_
16	after	after	IN	IN	_	15	case	_	_
17	LPS	lps	NN	NN	_	18	compound	_	_
18	addition	addition	NN	NN	_	15	dep	_	_
19	.	.	.	.	_	13	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	treated	treat	VBN	VBN	_	23	advcl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	4	nmod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	5	5	CD	CD	_	9	nummod	_	_
9	hours	hour	NNS	NNS	_	4	nmod	_	_
10	before	before	IN	IN	_	12	case	_	_
11	LPS	lps	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	23	punct	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	c-fos	c-fos	NN	NN	_	23	nsubjpass	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	c-jun	c-jun	NN	NN	_	16	conj	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	16	dep	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	decreased	decrease	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	c-fos	c-fos	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-jun	c-jun	NN	NN	_	4	conj	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IL-4	il-4	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	LPS-treated	lps-treated	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	22	mark	_	_
16	be	be	VB	VB	_	22	cop	_	_
17	due	due	JJ	JJ	_	22	case	_	_
18	to	to	TO	TO	_	17	mwe	_	_
19	a	a	DT	DT	_	22	det	_	_
20	lower	lower	JJR	JJR	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	rate	rate	NN	NN	_	14	xcomp	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	c-fos	c-fos	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	c-jun	c-jun	NN	NN	_	25	conj	_	_
28	genes	gene	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	IL-4	il-4	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	affect	affect	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	stability	stability	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	c-fos	c-fos	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	c-jun	c-jun	NN	NN	_	9	conj	_	_
12	transcripts	transcript	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	using	use	VBG	VBG	_	11	advcl	_	_
4	electrophoretic	electrophoretic	JJ	JJ	_	7	amod	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	3	dobj	_	_
8	,	,	,	,	_	11	punct	_	_
9	evidence	evidence	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	obtained	obtain	VBN	VBN	_	0	root	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	IL-4	il-4	NN	NN	_	14	nsubj	_	_
14	inhibits	inhibit	VBZ	VBZ	_	11	ccomp	_	_
15	LPS-induced	lps-induced	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	AP-1	ap-1	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IL-4	il-4	NN	NN	_	6	nsubj	_	_
6	suppresses	suppress	VBZ	VBZ	_	3	ccomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	induction	induction	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	activated	activate	VBN	VBN	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Ras	ras	NN	NN	_	3	compound	_	_
2	oncogene	oncogene	NN	NN	_	3	compound	_	_
3	transformation	transformation	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	lymphoblasts	lymphoblast	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	lymphocyte	lymphocyte	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	with	with	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	block	block	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	differentiation	differentiation	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	p21ras	p21ras	NN	NN	_	6	compound	_	_
3	small	small	JJ	JJ	_	6	amod	_	_
4	GTP	gtp	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	7	nsubj	_	_
7	participate	participate	VBP	VBP	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	signal	signal	JJ	JJ	_	10	amod	_	_
10	transduction	transduction	NN	NN	_	7	nmod	_	_
11	from	from	IN	IN	_	14	case	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	affect	affect	VB	VB	_	7	conj	_	_
17	neoplastic	neoplastic	JJ	JJ	_	18	amod	_	_
18	transformation	transformation	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	development	development	NN	NN	_	18	conj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	many	many	JJ	JJ	_	25	amod	_	_
23	different	different	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	types	type	NNS	NNS	_	18	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	relationship	relationship	NN	NN	_	7	dobj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	ras	ras	NN	NN	_	9	nmod	_	_
12	transformation	transformation	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	differentiation	differentiation	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	T24	t24	NN	NN	_	11	compound	_	_
10	Ha-ras	ha-ras	NN	NN	_	11	compound	_	_
11	oncogene	oncogene	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	EBV-immortalized	ebv-immortalized	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphoblasts	lymphoblast	NNS	NNS	_	6	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	associated	associate	VBN	VBN	_	2	ccomp	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	induction	induction	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	interleukin	interleukin	NN	NN	_	27	compound	_	_
24	2	2	CD	CD	_	27	nummod	_	_
25	receptor	receptor	NN	NN	_	27	compound	_	_
26	alpha	alpha	NN	NN	_	27	compound	_	_
27	subunit	subunit	NN	NN	_	20	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	with	with	IN	IN	_	34	case	_	_
30	an	a	DT	DT	_	34	det	_	_
31	impaired	impaired	JJ	JJ	_	34	amod	_	_
32	immunoglobulin	immunoglobulin	NN	NN	_	34	compound	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	17	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	altered	altered	JJ	JJ	_	38	amod	_	_
37	adhesion	adhesion	NN	NN	_	38	compound	_	_
38	properties	property	NNS	NNS	_	34	conj	_	_
39	and	and	CC	CC	_	34	cc	_	_
40	increased	increase	VBN	VBN	_	41	amod	_	_
41	survival	survival	NN	NN	_	34	conj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	serum-free	serum-free	JJ	JJ	_	44	amod	_	_
44	medium	medium	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	Since	since	IN	IN	_	11	mark	_	_
2	induction	induction	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	IL-2	il-2	NN	NN	_	8	compound	_	_
6	receptor	receptor	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	subunit	subunit	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	a	a	DT	DT	_	11	det	_	_
11	hallmark	hallmark	NN	NN	_	17	advcl	_	_
12	of	of	IN	IN	_	14	case	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	suggest	suggest	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	p21ras	p21ras	NN	NN	_	21	nsubj	_	_
20	naturally	naturally	RB	RB	_	21	advmod	_	_
21	triggers	trigger	VBZ	VBZ	_	17	ccomp	_	_
22	B	b	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ras-transformed	ras-transformed	JJ	JJ	_	3	amod	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	4	nsubj	_	_
4	displayed	display	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	fully	fully	RB	RB	_	7	advmod	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	IL-2r	il-2r	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	assessed	assess	VBN	VBN	_	4	advcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	c-fos	c-fos	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	following	follow	VBG	VBG	_	16	case	_	_
16	treatment	treatment	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	IL-2	il-2	NN	NN	_	16	nmod	_	_
19	;	;	:	:	_	4	punct	_	_
20	nevertheless	nevertheless	RB	RB	_	25	advmod	_	_
21	,	,	,	,	_	25	punct	_	_
22	they	they	PRP	PRP	_	25	nsubj	_	_
23	were	be	VBD	VBD	_	25	cop	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	growth	growth	NN	NN	_	4	parataxis	_	_
26	stimulated	stimulate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	lymphokine	lymphokine	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	decreased	decrease	VBN	VBN	_	3	amod	_	_
3	expression	expression	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	immunoglobulin	immunoglobulin	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	indicates	indicate	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	ras	ras	NN	NN	_	11	compound	_	_
11	oncogene	oncogene	NN	NN	_	12	nsubj	_	_
12	blocks	block	VBZ	VBZ	_	7	ccomp	_	_
13	terminal	terminal	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	plasma	plasma	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	possibly	possibly	RB	RB	_	21	advmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	inhibiting	inhibit	VBG	VBG	_	12	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Somewhat	somewhat	RB	RB	_	2	advmod	_	_
2	unexpectedly	unexpectedly	RB	RB	_	10	advmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
6	p21ras	p21ras	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	10	nsubj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	cause	cause	VB	VB	_	0	root	_	_
11	an	a	DT	DT	_	14	det	_	_
12	increased	increase	VBN	VBN	_	14	amod	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	PEA1	pea1	NN	NN	_	17	dep	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	AP1	ap1	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	PEA3	pea3	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	18	punct	_	_
25	Oct-2	oct-2	NN	NN	_	18	conj	_	_
26	or	or	CC	CC	_	18	cc	_	_
27	NF-kB	nf-kb	NN	NN	_	18	conj	_	_
28	.	.	.	.	_	10	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	GATA-1	gata-1	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	development	development	NN	NN	_	3	conj	_	_
7	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	derived	derive	VBD	VBD	_	0	root	_	_
6	an	a	DT	DT	_	8	det	_	_
7	experimental	experimental	JJ	JJ	_	8	amod	_	_
8	system	system	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	allows	allow	VBZ	VBZ	_	8	acl:relcl	_	_
11	us	we	PRP	PRP	_	10	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	dissect	dissect	VB	VB	_	10	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	function	function	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	GATA-1	gata-1	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	red	red	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	development	development	NN	NN	_	15	nmod	_	_
22	at	at	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	genetic	genetic	JJ	JJ	_	25	amod	_	_
25	level	level	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	established	establish	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	essential	essential	JJ	JJ	_	6	amod	_	_
6	nature	nature	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GATA-1	gata-1	NN	NN	_	6	nmod	_	_
9	during	during	IN	IN	_	14	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	primitive	primitive	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	definitive	definitive	JJ	JJ	_	11	conj	_	_
14	erythropoiesis	erythropoiesis	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	ablating	ablate	VBG	VBG	_	15	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	endogenous	endogenous	JJ	JJ	_	9	amod	_	_
8	GATA-1	gata-1	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	15	punct	_	_
11	we	we	PRP	PRP	_	15	nsubj	_	_
12	are	be	VBP	VBP	_	15	cop	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	position	position	NN	NN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	introduce	introduce	VB	VB	_	15	acl	_	_
18	a	a	DT	DT	_	19	det	_	_
19	variety	variety	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	constructs	construct	NNS	NNS	_	19	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	harbor	harbor	VBP	VBP	_	21	acl:relcl	_	_
24	subtle	subtle	JJ	JJ	_	25	amod	_	_
25	modifications	modification	NNS	NNS	_	23	dobj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	flanking	flanking	JJ	JJ	_	30	amod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	protein-coding	protein-coding	JJ	JJ	_	27	conj	_	_
30	sequences	sequence	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	study	study	VB	VB	_	0	root	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	regions	region	NNS	NNS	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	domains	domain	NNS	NNS	_	6	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	context	context	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	true	true	JJ	JJ	_	20	amod	_	_
19	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
20	environment	environment	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	4	punct	_	_
22	experiments	experiment	NNS	NNS	_	4	dobj	_	_
23	that	that	WDT	WDT	_	27	nsubj	_	_
24	have	have	VBP	VBP	_	27	aux	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	been	be	VBN	VBN	_	27	cop	_	_
27	possible	possible	JJ	JJ	_	22	acl:relcl	_	_
28	heretofore	heretofore	RB	RB	_	27	advmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	assay	assay	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	16	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	dramatic	dramatic	JJ	JJ	_	7	amod	_	_
7	loss	loss	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	red	red	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	it	it	PRP	PRP	_	16	nsubj	_	_
14	should	should	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	possible	possible	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	define	define	VB	VB	_	16	xcomp	_	_
19	important	important	JJ	JJ	_	21	amod	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	domains	domain	NNS	NNS	_	18	dobj	_	_
22	that	that	WDT	WDT	_	26	nsubjpass	_	_
23	can	can	MD	MD	_	26	aux	_	_
24	then	then	RB	RB	_	26	advmod	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	assayed	assay	VBN	VBN	_	21	acl:relcl	_	_
27	using	use	VBG	VBG	_	26	xcomp	_	_
28	less	less	RBR	RBR	_	29	advmod	_	_
29	stringent	stringent	JJ	JJ	_	30	amod	_	_
30	systems	system	NNS	NNS	_	27	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	such	such	JJ	JJ	_	35	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	cell-free	cell-free	JJ	JJ	_	35	amod	_	_
35	extracts	extract	NNS	NNS	_	30	nmod	_	_
36	for	for	IN	IN	_	39	case	_	_
37	in	in	FW	FW	_	39	amod	_	_
38	vitro	vitro	FW	FW	_	37	dep	_	_
39	transcription	transcription	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ideal	ideal	JJ	JJ	_	3	amod	_	_
3	situation	situation	NN	NN	_	6	nsubj	_	_
4	would	would	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	analyses	analysis	NNS	NNS	_	0	root	_	_
7	conducted	conduct	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	GATA-1-	gata-1-	JJ	JJ	_	11	amod	_	_
10	erythroid	erythroid	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	7	nsubj	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	cop	_	_
7	impossible	impossible	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	generate	generate	VB	VB	_	7	ccomp	_	_
10	given	give	VBN	VBN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	requirement	requirement	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GATA-1	gata-1	NN	NN	_	12	nmod	_	_
15	for	for	IN	IN	_	18	case	_	_
16	Epo	epo	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	red	red	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	viability	viability	NN	NN	_	18	conj	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	C.	C.	NNP	NNP	_	25	compound	_	_
25	Simon	Simon	NNP	NNP	_	7	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	S.	S.	NNP	NNP	_	28	compound	_	_
28	Orkin	Orkin	NNP	NNP	_	25	conj	_	_
29	,	,	,	,	_	25	punct	_	_
30	unpublished	unpublished	JJ	JJ	_	31	amod	_	_
31	observations	observation	NNS	NNS	_	25	appos	_	_
32	)	)	-RRB-	-RRB-	_	25	punct	_	_
33	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	cop	_	_
4	possible	possible	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	produce	produce	VB	VB	_	4	xcomp	_	_
7	such	such	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	6	dobj	_	_
9	by	by	IN	IN	_	11	mark	_	_
10	first	first	RB	RB	_	11	advmod	_	_
11	expressing	express	VBG	VBG	_	6	advcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Epo	epo	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	11	dobj	_	_
15	under	under	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	influence	influence	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	constitutive	constitutive	JJ	JJ	_	21	amod	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	then	then	RB	RB	_	24	advmod	_	_
24	targeting	target	VBG	VBG	_	11	conj	_	_
25	the	the	DT	DT	_	27	det	_	_
26	GATA-1	gata-1	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	If	if	IN	IN	_	6	mark	_	_
2	GATA-1-	gata-1-	JJ	JJ	_	4	amod	_	_
3	red	red	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	available	available	JJ	JJ	_	11	advcl	_	_
7	,	,	,	,	_	11	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	analyses	analysis	NNS	NNS	_	11	nsubj	_	_
10	would	would	MD	MD	_	11	aux	_	_
11	involve	involve	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	actual	actual	JJ	JJ	_	14	amod	_	_
14	transcription	transcription	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	14	acl	_	_
16	or	or	CC	CC	_	14	cc	_	_
17	chromatin	chromatin	NN	NN	_	18	compound	_	_
18	structure	structure	NN	NN	_	14	conj	_	_
19	surrounding	surround	VBG	VBG	_	18	acl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	globin	globin	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	14	dep	_	_
23	.	.	.	.	_	11	punct	_	_

1	Structure-function	structure-function	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	GATA-1	gata-1	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	could	could	MD	MD	_	10	aux	_	_
8	be	be	VB	VB	_	10	auxpass	_	_
9	greatly	greatly	RB	RB	_	10	advmod	_	_
10	simplified	simplify	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	a	a	DT	DT	_	14	det	_	_
13	larger	larger	JJR	JJR	_	14	amod	_	_
14	number	number	NN	NN	_	17	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	mutants	mutant	NNS	NNS	_	14	nmod	_	_
17	studied	study	VBN	VBN	_	10	conj	_	_
18	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	ES	es	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	system	system	NN	NN	_	9	nsubjpass	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	12	case	_	_
11	an	a	DT	DT	_	12	det	_	_
12	alternative	alternative	NN	NN	_	9	nmod	_	_
13	until	until	IN	IN	_	17	mark	_	_
14	targeted	target	VBN	VBN	_	16	amod	_	_
15	erythroleukemia	erythroleukemia	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	17	nsubj	_	_
17	become	become	VBP	VBP	_	9	advcl	_	_
18	available	available	JJ	JJ	_	17	xcomp	_	_
19	.	.	.	.	_	9	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	applications	application	NNS	NNS	_	3	nsubj	_	_
3	involve	involve	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	introduction	introduction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	other	other	JJ	JJ	_	11	amod	_	_
8	GATA-binding	gata-binding	JJ	JJ	_	11	amod	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	5	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	determine	determine	VB	VB	_	5	acl	_	_
14	whether	whether	IN	IN	_	16	mark	_	_
15	they	they	PRP	PRP	_	16	nsubj	_	_
16	rescue	rescue	VBP	VBP	_	13	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	mutation	mutation	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	If	if	IN	IN	_	3	mark	_	_
2	they	they	PRP	PRP	_	3	nsubj	_	_
3	can	can	MD	MD	_	10	advcl	_	_
4	not	not	RB	RB	_	3	neg	_	_
5	,	,	,	,	_	10	punct	_	_
6	chimeric	chimeric	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	10	nsubjpass	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	tested	test	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	identify	identify	VB	VB	_	10	xcomp	_	_
13	which	which	WDT	WDT	_	15	det	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	16	nsubj	_	_
16	distinguish	distinguish	VBP	VBP	_	12	ccomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	different	different	JJ	JJ	_	20	amod	_	_
19	family	family	NN	NN	_	20	compound	_	_
20	members	member	NNS	NNS	_	16	dobj	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	feel	feel	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	these	these	DT	DT	_	5	det	_	_
5	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	vital	vital	JJ	JJ	_	2	ccomp	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	understanding	understand	VBG	VBG	_	7	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	GATA-1	gata-1	NN	NN	_	11	nmod	_	_
14	during	during	IN	IN	_	16	case	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	ontogeny	ontogeny	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	How	how	WRB	WRB	_	4	advmod	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	GATA-1	gata-1	NN	NN	_	4	nsubj	_	_
4	regulate	regulate	VB	VB	_	0	root	_	_
5	red	red	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	4	dobj	_	_
8	like	like	IN	IN	_	9	case	_	_
9	globin	globin	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Epo	epo	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	conj	_	_
14	?	?	.	.	_	4	punct	_	_

1	Once	once	IN	IN	_	3	mark	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	identify	identify	VB	VB	_	13	advcl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	domains	domain	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GATA-binding	gata-binding	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	hope	hope	VBP	VBP	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	learn	learn	VB	VB	_	13	xcomp	_	_
16	what	what	WP	WP	_	17	det	_	_
17	proteins	protein	NNS	NNS	_	19	nmod	_	_
18	GATA-1	gata-1	NN	NN	_	19	nsubj	_	_
19	binds	bind	VBZ	VBZ	_	15	ccomp	_	_
20	to	to	TO	TO	_	17	case	_	_
21	in	in	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	basic	basic	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	machinery	machinery	NN	NN	_	19	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	in	in	IN	IN	_	28	case	_	_
28	chromatin	chromatin	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	Is	be	VBZ	VBZ	_	3	cop	_	_
2	GATA-1	gata-1	NN	NN	_	3	nsubj	_	_
3	necessary	necessary	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	globin	globin	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	switching	switching	NN	NN	_	3	nmod	_	_
8	?	?	.	.	_	3	punct	_	_

1	GATA-1	gata-1	NN	NN	_	4	nsubjpass	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	modified	modify	VBN	VBN	_	0	root	_	_
5	differently	differently	RB	RB	_	4	advmod	_	_
6	during	during	IN	IN	_	7	case	_	_
7	development	development	NN	NN	_	4	nmod	_	_
8	so	so	IN	IN	_	15	mark	_	_
9	that	that	IN	IN	_	8	mwe	_	_
10	the	the	DT	DT	_	13	det	_	_
11	locus	locus	NN	NN	_	13	compound	_	_
12	control	control	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	15	nsubj	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	interact	interact	VB	VB	_	4	advcl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	different	different	JJ	JJ	_	19	amod	_	_
18	globin	globin	NN	NN	_	19	compound	_	_
19	promoters	promoter	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	find	find	VB	VB	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	one	one	CD	CD	_	6	nummod	_	_
6	region	region	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	protein	protein	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	3	ccomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	embryonic	embryonic	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	another	another	DT	DT	_	11	conj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	adult	adult	JJ	JJ	_	21	amod	_	_
19	globin	globin	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	16	dep	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	zinc	zinc	NN	NN	_	6	compound	_	_
3	finger	finger	NN	NN	_	6	compound	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	Egr-1	egr-1	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	essential	essential	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	8	nmod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	restricts	restrict	VBZ	VBZ	_	8	conj	_	_
12	differentiation	differentiation	NN	NN	_	8	dobj	_	_
13	along	along	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	macrophage	macrophage	NN	NN	_	16	compound	_	_
16	lineage	lineage	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	14	case	_	_
7	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
8	differentiation	differentiation	NN	NN	_	10	compound	_	_
9	primary	primary	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MyD	myd	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	genes	gene	NNS	NNS	_	5	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	activated	activate	VBN	VBN	_	5	acl	_	_
17	in	in	IN	IN	_	24	case	_	_
18	the	the	DT	DT	_	24	dep	_	_
19	absence	absence	NN	NN	_	24	dep	_	_
20	of	of	IN	IN	_	24	case	_	_
21	de	de	FW	FW	_	24	amod	_	_
22	novo	novo	FW	FW	_	21	dep	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	synthesis	synthesis	NN	NN	_	16	nmod	_	_
25	following	follow	VBG	VBG	_	26	case	_	_
26	induction	induction	NN	NN	_	24	nmod	_	_
27	for	for	IN	IN	_	28	case	_	_
28	differentiation	differentiation	NN	NN	_	26	nmod	_	_
29	along	along	IN	IN	_	35	case	_	_
30	either	either	CC	CC	_	35	cc:preconj	_	_
31	the	the	DT	DT	_	35	det	_	_
32	macrophage	macrophage	NN	NN	_	35	compound	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	granulocyte	granulocyte	NN	NN	_	32	conj	_	_
35	lineage	lineage	NN	NN	_	28	nmod	_	_
36	in	in	IN	IN	_	41	case	_	_
37	human	human	JJ	JJ	_	41	amod	_	_
38	myeloblastic	myeloblastic	JJ	JJ	_	41	amod	_	_
39	leukemia	leukemia	NN	NN	_	41	compound	_	_
40	HL-60	hl-60	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	35	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	primary	primary	JJ	JJ	_	8	amod	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	expressed	express	VBN	VBN	_	3	acl	_	_
11	upon	upon	IN	IN	_	13	case	_	_
12	macrophage	macrophage	NN	NN	_	13	compound	_	_
13	differentiation	differentiation	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	encoded	encode	VBD	VBD	_	0	root	_	_
16	for	for	IN	IN	_	17	case	_	_
17	Egr-1	egr-1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	23	det	_	_
20	zinc	zinc	NN	NN	_	23	compound	_	_
21	finger	finger	NN	NN	_	23	compound	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	17	appos	_	_
24	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Egr-1	egr-1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	mark	_	_
7	be	be	VB	VB	_	9	cop	_	_
8	transcriptionally	transcriptionally	RB	RB	_	9	advmod	_	_
9	silent	silent	JJ	JJ	_	5	xcomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	HL-60	hl-60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	but	but	CC	CC	_	9	cc	_	_
15	active	active	JJ	JJ	_	9	conj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	U-937	u-937	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	M1	m1	NN	NN	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	the	the	DT	DT	_	24	det	_	_
23	latter	latter	JJ	JJ	_	24	amod	_	_
24	two	two	CD	CD	_	26	nsubjpass	_	_
25	being	be	VBG	VBG	_	26	auxpass	_	_
26	predetermined	predetermine	VBN	VBN	_	9	advcl	_	_
27	for	for	IN	IN	_	29	case	_	_
28	macrophage	macrophage	NN	NN	_	29	compound	_	_
29	differentiation	differentiation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Egr-1	egr-1	NN	NN	_	3	compound	_	_
2	antisense	antisense	JJ	JJ	_	3	amod	_	_
3	oligomers	oligomer	NNS	NNS	_	8	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	culture	culture	NN	NN	_	7	compound	_	_
7	media	media	NNS	NNS	_	3	nmod	_	_
8	blocked	block	VBD	VBD	_	0	root	_	_
9	macrophage	macrophage	NN	NN	_	10	compound	_	_
10	differentiation	differentiation	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	16	case	_	_
12	both	both	DT	DT	_	16	cc:preconj	_	_
13	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	8	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	myeloblasts	myeloblast	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	HL-60	hl-60	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	13	nsubjpass	_	_
3	constitutively	constitutively	RB	RB	_	4	advmod	_	_
4	expressing	express	VBG	VBG	_	2	acl	_	_
5	an	a	DT	DT	_	7	det	_	_
6	Egr-1	egr-1	NN	NN	_	7	compound	_	_
7	transgene	transgene	NN	NN	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HL-60Egr-1	hl-60egr-1	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	could	could	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	21	case	_	_
15	macrophage	macrophage	NN	NN	_	21	compound	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	15	cc	_	_
19	granulocyte	granulocyte	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	differentiation	differentiation	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	expression	expression	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Egr-1	egr-1	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	3	ccomp	_	_
10	for	for	IN	IN	_	9	nmod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	restricts	restrict	VBZ	VBZ	_	9	conj	_	_
13	differentiation	differentiation	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	myeloblasts	myeloblast	NNS	NNS	_	13	nmod	_	_
16	along	along	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	macrophage	macrophage	NN	NN	_	19	compound	_	_
19	lineage	lineage	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	lymphokine	lymphokine	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	:	:	:	:	_	1	punct	_	_
9	role	role	NN	NN	_	1	dep	_	_
10	of	of	IN	IN	_	13	case	_	_
11	cis-acting	cis-acting	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	respond	respond	VBP	VBP	_	13	acl:relcl	_	_
16	to	to	TO	TO	_	20	case	_	_
17	T	t	NN	NN	_	20	compound	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	signals	signal	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	initiated	initiate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	recognition	recognition	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	antigen	antigen	NN	NN	_	9	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	antigen	antigen	NN	NN	_	15	compound	_	_
14	presenting	presenting	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	exert	exert	VB	VB	_	9	acl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	effector	effector	NN	NN	_	20	compound	_	_
20	functions	function	NNS	NNS	_	17	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	immune	immune	JJ	JJ	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	inflammatory	inflammatory	JJ	JJ	_	22	conj	_	_
25	responses	response	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	types	type	NNS	NNS	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	helper	helper	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cell	cell	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Th	th	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	clones	clone	NNS	NNS	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Th1	th1	NN	NN	_	2	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Th2	th2	NN	NN	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	defined	define	VBN	VBN	_	0	root	_	_
18	on	on	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	dep	_	_
20	basis	basis	NN	NN	_	23	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	different	different	JJ	JJ	_	23	amod	_	_
23	patterns	pattern	NNS	NNS	_	17	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	cytokine	cytokine	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	lymphokine	lymphokine	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	secretion	secretion	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	determine	determine	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	outcome	outcome	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	antigenic	antigenic	JJ	JJ	_	8	amod	_	_
8	response	response	NN	NN	_	4	nmod	_	_
9	toward	toward	IN	IN	_	13	case	_	_
10	humoral	humoral	JJ	JJ	_	13	amod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	cell-mediated	cell-mediated	JJ	JJ	_	10	conj	_	_
13	immunity	immunity	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	lymphokine	lymphokine	NN	NN	_	3	compound	_	_
3	genes	gene	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	coordinately	coordinately	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	13	advcl	_	_
7	upon	upon	IN	IN	_	9	case	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	they	they	PRP	PRP	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mechanisms	mechanism	NNS	NNS	_	13	nmod	_	_
17	common	common	JJ	JJ	_	16	amod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	all	all	DT	DT	_	17	nmod	_	_
20	as	as	RB	RB	_	16	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	those	those	DT	DT	_	16	conj	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	unique	unique	JJ	JJ	_	23	acl:relcl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	each	each	DT	DT	_	29	det	_	_
29	gene	gene	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	For	for	IN	IN	_	4	case	_	_
2	most	most	JJS	JJS	_	4	amod	_	_
3	lymphokine	lymphokine	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	26	nmod	_	_
5	,	,	,	,	_	26	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	combination	combination	NN	NN	_	26	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	phorbol	phorbol	NN	NN	_	10	compound	_	_
10	esters	ester	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	phorbol	phorbol	NN	NN	_	15	compound	_	_
13	12-myristate	12-myristate	NN	NN	_	15	compound	_	_
14	13	13	CD	CD	_	15	nummod	_	_
15	acetate	acetate	NN	NN	_	10	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	calcium	calcium	NN	NN	_	21	compound	_	_
21	ionophores	ionophore	NNS	NNS	_	10	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	A23187	a23187	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	required	require	VBN	VBN	_	0	root	_	_
27	for	for	IN	IN	_	30	case	_	_
28	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
29	maximal	maximal	JJ	JJ	_	30	amod	_	_
30	induction	induction	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	26	punct	_	_

1	Yet	yet	RB	RB	_	9	advmod	_	_
2	phorbol	phorbol	NN	NN	_	3	compound	_	_
3	ester	ester	NN	NN	_	9	nsubj	_	_
4	alone	alone	RB	RB	_	3	advmod	_	_
5	or	or	CC	CC	_	3	cc	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	ionophore	ionophore	NN	NN	_	3	conj	_	_
8	alone	alone	RB	RB	_	7	advmod	_	_
9	produce	produce	VBP	VBP	_	0	root	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	lymphokines	lymphokine	NNS	NNS	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	production	production	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	8	amod	_	_
6	colony	colony	NN	NN	_	8	compound	_	_
7	stimulating	stimulating	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	GM-CSF	gm-csf	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	completely	completely	RB	RB	_	14	advmod	_	_
14	dependent	dependent	JJ	JJ	_	0	root	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	signals	signal	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	cis-acting	cis-acting	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	4	dobj	_	_
8	spanning	span	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	GM-CSF	gm-csf	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	8	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	positions	position	NNS	NNS	_	12	appos	_	_
15	-95	-95	CD	CD	_	14	dep	_	_
16	to	to	TO	TO	_	15	dep	_	_
17	+27	+27	CD	CD	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	confers	confer	VBZ	VBZ	_	12	acl:relcl	_	_
21	inducibility	inducibility	NN	NN	_	20	dobj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	reporter	reporter	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	transient	transient	JJ	JJ	_	28	amod	_	_
27	transfection	transfection	NN	NN	_	28	compound	_	_
28	assays	assay	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	three	three	CD	CD	_	5	nummod	_	_
5	elements	element	NNS	NNS	_	3	dobj	_	_
6	required	require	VBN	VBN	_	5	acl	_	_
7	for	for	IN	IN	_	9	case	_	_
8	efficient	efficient	JJ	JJ	_	9	amod	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	referred	refer	VBN	VBN	_	5	acl	_	_
12	to	to	TO	TO	_	11	nmod	_	_
13	as	as	IN	IN	_	14	case	_	_
14	GM2	gm2	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	GC-box	gc-box	NN	NN	_	14	conj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	conserved	conserve	VBN	VBN	_	20	amod	_	_
19	lymphokine	lymphokine	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	14	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CLE0	cle0	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	3	punct	_	_

1	GM2	gm2	NN	NN	_	2	nsubj	_	_
2	defines	define	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	site	site	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	5	nmod	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
12	binding	binding	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	inducible	inducible	JJ	JJ	_	9	acl:relcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PMA	pma	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	protein	protein	NN	NN	_	6	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	NF-GM2	nf-gm2	NN	NN	_	2	appos	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	similar	similar	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	NF-kB	nf-kb	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	GC-box	gc-box	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	site	site	NN	NN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	bound	bind	VBN	VBN	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	CLEO	cleo	NN	NN	_	2	nsubj	_	_
2	defines	define	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	site	site	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	5	nmod	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	whose	whose	WP$	WP$	_	13	nmod:poss	_	_
12	optimum	optimum	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	stimulated	stimulate	VBN	VBN	_	9	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	PMA	pma	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	A23187	a23187	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	Viral	viral	JJ	JJ	_	2	amod	_	_
2	trans-activators	trans-activator	NNS	NNS	_	27	nsubj	_	_
3	such	such	JJ	JJ	_	24	case	_	_
4	as	as	IN	IN	_	3	mwe	_	_
5	Tax	tax	NN	NN	_	24	compound	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	virus-1	virus-1	NN	NN	_	5	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	HTLV-1	htlv-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	E2	e2	NN	NN	_	5	conj	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	bovine	bovine	JJ	JJ	_	20	amod	_	_
19	papilloma	papilloma	NN	NN	_	20	compound	_	_
20	virus	virus	NN	NN	_	16	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	BPV	bpv	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	proteins	protein	NNS	NNS	_	2	nmod	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	agents	agent	NNS	NNS	_	0	root	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	activate	activate	VBP	VBP	_	27	acl:relcl	_	_
30	lymphokine	lymphokine	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	29	dobj	_	_
33	by	by	IN	IN	_	34	mark	_	_
34	bypassing	bypass	VBG	VBG	_	29	advcl	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	41	nmod:npmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	TCR	tcr	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	mediated	mediated	JJ	JJ	_	42	amod	_	_
42	signaling	signaling	NN	NN	_	34	dobj	_	_
43	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	trans-activation	trans-activation	NN	NN	_	3	compound	_	_
3	domain	domain	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	E2	e2	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Tax	tax	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	interchangeable	interchangeable	JJ	JJ	_	0	root	_	_
10	although	although	IN	IN	_	12	mark	_	_
11	they	they	PRP	PRP	_	12	nsubj	_	_
12	have	have	VBP	VBP	_	9	advcl	_	_
13	no	no	DT	DT	_	16	neg	_	_
14	obvious	obvious	JJ	JJ	_	16	amod	_	_
15	sequence	sequence	NN	NN	_	16	compound	_	_
16	homology	homology	NN	NN	_	12	dobj	_	_
17	between	between	IN	IN	_	18	case	_	_
18	them	they	PRP	PRP	_	16	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	viral	viral	JJ	JJ	_	3	amod	_	_
3	trans-activators	trans-activator	NNS	NNS	_	4	nsubj	_	_
4	appear	appear	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	target	target	VB	VB	_	4	xcomp	_	_
7	specific	specific	JJ	JJ	_	10	amod	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	dobj	_	_
11	such	such	JJ	JJ	_	13	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	NF-kB	nf-kb	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Sp1	sp1	NN	NN	_	13	conj	_	_
16	to	to	TO	TO	_	19	case	_	_
17	cis-acting	cis-acting	JJ	JJ	_	19	amod	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	6	nmod	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	promote	promote	VB	VB	_	6	conj	_	_
22	lymphokine	lymphokine	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	dobj	_	_
25	without	without	IN	IN	_	27	case	_	_
26	TCR-mediated	tcr-mediated	JJ	JJ	_	27	amod	_	_
27	stimulation	stimulation	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	tal-1	tal-1	NN	NN	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	GATA-binding	gata-binding	JJ	JJ	_	3	conj	_	_
6	proteins	protein	NNS	NNS	_	1	nmod	_	_
7	during	during	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	hematopoiesis	hematopoiesis	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Tal-1	tal-1	NN	NN	_	2	compound	_	_
2	rearrangements	rearrangement	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	nearly	nearly	RB	RB	_	7	advmod	_	_
7	30	30	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	lymphoblastic	lymphoblastic	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Tal-1	tal-1	NN	NN	_	2	compound	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	encodes	encode	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	putative	putative	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	with	with	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	basic	basic	JJ	JJ	_	12	amod	_	_
11	helix-loop-helix	helix-loop-helix	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	known	know	VBN	VBN	_	3	conj	_	_
16	to	to	TO	TO	_	19	mark	_	_
17	be	be	VB	VB	_	19	auxpass	_	_
18	predominantly	predominantly	RB	RB	_	19	advmod	_	_
19	expressed	express	VBN	VBN	_	15	xcomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	pattern	pattern	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	tal-1	tal-1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	purified	purify	VBN	VBN	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	situ	situ	FW	FW	_	14	dep	_	_
16	hybridization	hybridization	NN	NN	_	2	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	reverse	reverse	JJ	JJ	_	23	amod	_	_
19	transcriptase	transcriptase	NN	NN	_	23	compound	_	_
20	polymerase	polymerase	NN	NN	_	23	compound	_	_
21	chain	chain	NN	NN	_	23	compound	_	_
22	reaction	reaction	NN	NN	_	23	compound	_	_
23	analysis	analysis	NN	NN	_	16	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	methods	method	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	tal-1	tal-1	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	megakaryocytes	megakaryocyte	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	erythroblasts	erythroblast	NNS	NNS	_	11	conj	_	_
14	as	as	RB	RB	_	11	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	in	in	IN	IN	_	19	case	_	_
18	basophilic	basophilic	JJ	JJ	_	19	amod	_	_
19	granulocytes	granulocyte	NNS	NNS	_	11	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	21	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	tal-1	tal-1	NN	NN	_	11	compound	_	_
10	1A	1a	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	21	nsubj	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	contains	contain	VBZ	VBZ	_	11	acl:relcl	_	_
15	two	two	CD	CD	_	18	nummod	_	_
16	consensus	consensus	NN	NN	_	18	compound	_	_
17	GATA-binding	gata-binding	JJ	JJ	_	18	amod	_	_
18	sites	site	NNS	NNS	_	14	dobj	_	_
19	,	,	,	,	_	11	punct	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	active	active	JJ	JJ	_	6	ccomp	_	_
22	mainly	mainly	RB	RB	_	25	advmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	lineages	lineage	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	GATA-1	gata-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	23	advcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	transactivate	transactivate	VB	VB	_	6	xcomp	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	8	dobj	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	20	case	_	_
13	the	the	DT	DT	_	20	det	_	_
14	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
15	,	,	,	,	_	14	punct	_	_
16	megakaryocytic	megakaryocytic	JJ	JJ	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	mastocytic/basophilic	mastocytic/basophilic	JJ	JJ	_	14	conj	_	_
20	lineages	lineage	NNS	NNS	_	11	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	studied	study	VBD	VBD	_	0	root	_	_
24	GATA-1	gata-1	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	these	these	DT	DT	_	30	det	_	_
28	purified	purify	VBN	VBN	_	30	amod	_	_
29	hematopoietic	hematopoietic	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	GATA-1	gata-1	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	tal-1	tal-1	NN	NN	_	4	conj	_	_
7	genes	gene	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	coexpressed	coexpress	VBN	VBN	_	2	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	these	these	DT	DT	_	13	det	_	_
12	three	three	CD	CD	_	13	nummod	_	_
13	lineages	lineage	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Remarkably	remarkably	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	DT	DT	_	7	det	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	downmodulated	downmodulate	VBN	VBN	_	0	root	_	_
10	during	during	IN	IN	_	15	case	_	_
11	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	megakaryocytic	megakaryocytic	JJ	JJ	_	11	conj	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	maturation	maturation	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	immature	immature	JJ	JJ	_	4	amod	_	_
3	hematopoietic	hematopoietic	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	tal-1	tal-1	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	GATA-1	gata-1	NN	NN	_	6	conj	_	_
9	genes	gene	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	coexpressed	coexpress	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	committed	commit	VBN	VBN	_	15	amod	_	_
14	progenitors	progenitor	NNS	NNS	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CD34+/CD38(2+)	cd34+/cd38(2+)	JJ	JJ	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	11	punct	_	_
20	whereas	whereas	IN	IN	_	24	mark	_	_
21	they	they	PRP	PRP	_	24	nsubj	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	detectable	detectable	JJ	JJ	_	11	advcl	_	_
25	in	in	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	most	most	RBS	RBS	_	28	advmod	_	_
28	primitive	primitive	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CD34(2+)/CD38-	cd34(2+)/cd38-	JJ	JJ	_	29	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	GATA-2	gata-2	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	strongly	strongly	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	most	most	RBS	RBS	_	11	advmod	_	_
11	primitive	primitive	JJ	JJ	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	committed	commit	VBN	VBN	_	14	amod	_	_
14	progenitors	progenitor	NNS	NNS	_	11	conj	_	_
15	cells	cell	NNS	NNS	_	11	dep	_	_
16	,	,	,	,	_	7	punct	_	_
17	whereas	whereas	IN	IN	_	7	dep	_	_
18	GATA-3	gata-3	NN	NN	_	21	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	mostly	mostly	RB	RB	_	21	advmod	_	_
21	detected	detect	VBN	VBN	_	7	parataxis	_	_
22	in	in	IN	IN	_	25	case	_	_
23	most	most	RBS	RBS	_	24	advmod	_	_
24	primitive	primitive	JJ	JJ	_	25	amod	_	_
25	ones	one	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	results	result	NNS	NNS	_	5	nsubj	_	_
4	strongly	strongly	RB	RB	_	5	advmod	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	GATA-1	gata-1	NN	NN	_	8	nsubj	_	_
8	modulates	modulate	VBZ	VBZ	_	5	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	transcription	transcription	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	tal-1	tal-1	NN	NN	_	10	nmod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	differentiation	differentiation	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	24	case	_	_
17	the	the	DT	DT	_	24	det	_	_
18	erythroid	erythroid	JJ	JJ	_	24	amod	_	_
19	,	,	,	,	_	18	punct	_	_
20	megakaryocytic	megakaryocytic	JJ	JJ	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	basosophilic	basosophilic	JJ	JJ	_	18	conj	_	_
24	lineages	lineage	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Cell-type-specific	cell-type-specific	JJ	JJ	_	2	amod	_	_
2	transactivation	transactivation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	parathyroid	parathyroid	JJ	JJ	_	6	amod	_	_
6	hormone-related	hormone-related	JJ	JJ	_	9	amod	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	2	nmod	_	_
10	by	by	IN	IN	_	25	case	_	_
11	the	the	DT	DT	_	25	det	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	T-cell	t-cell	NN	NN	_	16	compound	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	type	type	NN	NN	_	21	compound	_	_
17	I	i	CD	CD	_	16	nummod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HTLV-I	htlv-i	NN	NN	_	21	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	tax	tax	NN	NN	_	25	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	HTLV-II	htlv-ii	NN	NN	_	24	compound	_	_
24	tax	tax	NN	NN	_	21	conj	_	_
25	proteins	protein	NNS	NNS	_	2	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	14	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	T-cell	t-cell	NN	NN	_	6	compound	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	14	compound	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	HTLV-II	htlv-ii	NN	NN	_	6	conj	_	_
13	Tax	tax	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	17	nsubj	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	potent	potent	JJ	JJ	_	17	amod	_	_
17	transactivators	transactivator	NNS	NNS	_	0	root	_	_
18	of	of	IN	IN	_	23	case	_	_
19	viral	viral	JJ	JJ	_	23	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	cellular	cellular	JJ	JJ	_	19	conj	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	Using	use	VBG	VBG	_	15	advcl	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	15	punct	_	_
5	the	the	DT	DT	_	13	det	_	_
6	downstream	downstream	JJ	JJ	_	13	amod	_	_
7	parathyroid	parathyroid	JJ	JJ	_	8	amod	_	_
8	hormone-related	hormone-related	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PTHrP	pthrp	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	promoter	promoter	NN	NN	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	responsive	responsive	JJ	JJ	_	15	xcomp	_	_
19	to	to	TO	TO	_	24	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	HTLV-I	htlv-i	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	HTLV-II	htlv-ii	NN	NN	_	21	conj	_	_
24	Tax	tax	NN	NN	_	18	nmod	_	_
25	as	as	RB	RB	_	24	cc	_	_
26	well	well	RB	RB	_	25	mwe	_	_
27	as	as	IN	IN	_	25	mwe	_	_
28	the	the	DT	DT	_	30	det	_	_
29	AP1/c-jun	ap1/c-jun	NN	NN	_	30	compound	_	_
30	proto-oncogene	proto-oncogene	NN	NN	_	24	conj	_	_
31	.	.	.	.	_	15	punct	_	_

1	Transactivation	transactivation	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PTHrP	pthrp	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	5	case	_	_
5	Tax	tax	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	seen	see	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	10	conj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	15	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	carboxy	carboxy	NN	NN	_	6	compound	_	_
3	terminal	terminal	JJ	JJ	_	6	amod	_	_
4	Tax	tax	NN	NN	_	6	compound	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	mutant	mutant	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	deficient	deficient	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	transactivation	transactivation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	18	case	_	_
12	both	both	CC	CC	_	18	cc:preconj	_	_
13	the	the	DT	DT	_	18	det	_	_
14	PTHrP	pthrp	NN	NN	_	18	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL2R	il2r	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	14	conj	_	_
18	promoters	promoter	NNS	NNS	_	10	nmod	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	18	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	HTLV-I	htlv-i	NN	NN	_	18	conj	_	_
23	long	long	JJ	JJ	_	25	amod	_	_
24	terminal	terminal	JJ	JJ	_	25	amod	_	_
25	repeat	repeat	NN	NN	_	22	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	LTR	ltr	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	8	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	2	amod	_	_
2	provision	provision	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFkB	nfkb	NN	NN	_	2	nmod	_	_
5	rescued	rescue	VBD	VBD	_	0	root	_	_
6	IL2R	il2r	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	PTHrP	pthrp	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	8	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	HTLV-I	htlv-i	NN	NN	_	4	compound	_	_
4	Tax	tax	NN	NN	_	11	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	HTLV-II	htlv-ii	NN	NN	_	7	compound	_	_
7	Tax	tax	NN	NN	_	4	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	c-jun	c-jun	NN	NN	_	4	conj	_	_
11	transactivate	transactivate	VBP	VBP	_	0	root	_	_
12	PTHrP	pthrp	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	contribute	contribute	VB	VB	_	11	conj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	pathogenesis	pathogenesis	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	hypercalcemia	hypercalcemia	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	adult	adult	JJ	JJ	_	24	amod	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	leukemia	leukemia	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	Interleukin-3	interleukin-3	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	by	by	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	involves	involve	VBZ	VBZ	_	0	root	_	_
8	an	a	DT	DT	_	12	det	_	_
9	inducible	inducible	JJ	JJ	_	12	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	T-cell-specific	t-cell-specific	JJ	JJ	_	9	dep	_	_
12	factor	factor	NN	NN	_	7	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	an	a	DT	DT	_	17	det	_	_
15	octamer	octamer	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Interleukin-3	interleukin-3	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-3	il-3	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	7	aux	_	_
6	exclusively	exclusively	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	activated	activate	VBN	VBN	_	10	amod	_	_
10	T	t	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	natural	natural	JJ	JJ	_	13	amod	_	_
13	killer	killer	NN	NN	_	10	conj	_	_
14	cells	cell	NNS	NNS	_	10	dep	_	_
15	,	,	,	,	_	7	punct	_	_
16	a	a	DT	DT	_	17	det	_	_
17	function	function	NN	NN	_	7	dobj	_	_
18	that	that	WDT	WDT	_	21	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	tightly	tightly	RB	RB	_	21	advmod	_	_
21	controlled	control	VBN	VBN	_	17	acl:relcl	_	_
22	both	both	CC	CC	_	25	cc:preconj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	lineage-specific	lineage-specific	JJ	JJ	_	30	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	in	in	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	stimulation-dependent	stimulation-dependent	JJ	JJ	_	25	conj	_	_
30	manner	manner	NN	NN	_	21	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	characteristics	characteristic	NNS	NNS	_	3	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	importance	importance	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	ACT-1-activating	act-1-activating	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	IL-3	il-3	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	binds	bind	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	8	det	_	_
5	inducible	inducible	JJ	JJ	_	8	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	T-cell-specific	t-cell-specific	JJ	JJ	_	5	dep	_	_
8	factor	factor	NN	NN	_	3	dobj	_	_
9	over	over	IN	IN	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	5'	5'	JJ	JJ	_	12	amod	_	_
12	end	end	NN	NN	_	3	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	15	det	_	_
15	site	site	NN	NN	_	12	appos	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	necessary	necessary	JJ	JJ	_	15	acl:relcl	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-3	il-3	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	30	case	_	_
25	the	the	DT	DT	_	30	dep	_	_
26	absence	absence	NN	NN	_	30	dep	_	_
27	of	of	IN	IN	_	30	case	_	_
28	other	other	JJ	JJ	_	30	amod	_	_
29	upstream	upstream	JJ	JJ	_	30	amod	_	_
30	elements	element	NNS	NNS	_	18	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Over	over	IN	IN	_	4	case	_	_
2	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
3	3'	3'	JJ	JJ	_	4	amod	_	_
4	end	end	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	it	it	PRP	PRP	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	factor	factor	NN	NN	_	7	dobj	_	_
10	that	that	WDT	WDT	_	15	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	15	auxpass	_	_
12	ubiquitously	ubiquitously	RB	RB	_	13	advmod	_	_
13	and	and	CC	CC	_	15	advmod	_	_
14	constitutively	constitutively	RB	RB	_	13	advmod	_	_
15	expressed	express	VBN	VBN	_	9	acl:relcl	_	_
16	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	Oct-1	oct-1	NN	NN	_	0	root	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	an	a	DT	DT	_	10	det	_	_
7	immunologically	immunologically	RB	RB	_	8	advmod	_	_
8	related	related	JJ	JJ	_	10	amod	_	_
9	octamer-binding	octamer-binding	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	it	it	PRP	PRP	_	14	nsubj	_	_
14	plays	play	VBZ	VBZ	_	4	conj	_	_
15	a	a	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	coordinating	coordinate	VBG	VBG	_	14	advcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	several	several	JJ	JJ	_	24	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	elements	element	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	characteristics	characteristic	NNS	NNS	_	3	nsubj	_	_
3	make	make	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	ACT-1	act-1	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	7	nsubj	_	_
7	analogous	analogous	JJ	JJ	_	3	xcomp	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	activating	activate	VBG	VBG	_	12	amod	_	_
11	ARRE-1	arre-1	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	3	advmod	_	_
2	,	,	,	,	_	3	punct	_	_
3	and	and	CC	CC	_	17	advmod	_	_
4	despite	despite	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	lack	lack	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	sequence	sequence	NN	NN	_	9	compound	_	_
9	homology	homology	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	17	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	promoters	promoter	NNS	NNS	_	17	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-3	il-3	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-2	il-2	NN	NN	_	14	conj	_	_
17	share	share	VBP	VBP	_	0	root	_	_
18	an	a	DT	DT	_	20	det	_	_
19	organizational	organizational	JJ	JJ	_	20	amod	_	_
20	pattern	pattern	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	regulatory	regulatory	JJ	JJ	_	23	amod	_	_
23	elements	element	NNS	NNS	_	20	nmod	_	_
24	that	that	WDT	WDT	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	likely	likely	JJ	JJ	_	20	acl:relcl	_	_
27	to	to	TO	TO	_	29	mark	_	_
28	be	be	VB	VB	_	29	cop	_	_
29	important	important	JJ	JJ	_	26	xcomp	_	_
30	for	for	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	T-cell-specific	t-cell-specific	JJ	JJ	_	33	amod	_	_
33	expression	expression	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	genes	gene	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	I	i	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B/MAD-3	b/mad-3	NN	NN	_	4	nsubj	_	_
4	masks	mask	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	localization	localization	NN	NN	_	8	compound	_	_
8	signal	signal	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	p65	p65	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	requires	require	VBZ	VBZ	_	4	conj	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transactivation	transactivation	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	14	dobj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	inhibit	inhibit	VB	VB	_	14	xcomp	_	_
20	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
21	B	b	NN	NN	_	24	compound	_	_
22	p65	p65	NN	NN	_	24	compound	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	19	dobj	_	_
25	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	active	active	JJ	JJ	_	4	amod	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	form	form	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
8	B	b	NN	NN	_	11	compound	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	complex	complex	NN	NN	_	4	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	composed	compose	VBN	VBN	_	0	root	_	_
14	of	of	IN	IN	_	18	case	_	_
15	two	two	CD	CD	_	18	nummod	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	subunits	subunit	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	p65	p65	NN	NN	_	18	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	p50	p50	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	18	punct	_	_
28	both	both	DT	DT	_	31	nsubj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	which	which	WDT	WDT	_	28	nmod	_	_
31	share	share	VBP	VBP	_	18	acl:relcl	_	_
32	extensive	extensive	JJ	JJ	_	35	amod	_	_
33	N-terminal	n-terminal	JJ	JJ	_	35	amod	_	_
34	sequence	sequence	NN	NN	_	35	compound	_	_
35	homology	homology	NN	NN	_	31	dobj	_	_
36	with	with	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	v-rel	v-rel	NN	NN	_	40	compound	_	_
39	oncogene	oncogene	NN	NN	_	40	compound	_	_
40	product	product	NN	NN	_	31	nmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	p65	p65	NN	NN	_	5	compound	_	_
5	subunit	subunit	NN	NN	_	6	nsubj	_	_
6	provides	provide	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transactivation	transactivation	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	complex	complex	JJ	JJ	_	6	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	serves	serve	VBZ	VBZ	_	6	conj	_	_
15	as	as	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	receptor	receptor	NN	NN	_	14	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	cytoplasmic	cytoplasmic	JJ	JJ	_	22	amod	_	_
22	inhibitor	inhibitor	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	22	punct	_	_
27	termed	term	VBN	VBN	_	22	acl	_	_
28	I	i	NN	NN	_	30	compound	_	_
29	kappa	kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	xcomp	_	_
31	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	p50	p50	NN	NN	_	8	nsubj	_	_
7	alone	alone	RB	RB	_	6	advmod	_	_
8	fails	fail	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	stimulate	stimulate	VB	VB	_	8	xcomp	_	_
11	kappa	kappa	NN	NN	_	12	nmod:npmod	_	_
12	B-directed	b-directed	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	8	punct	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	based	base	VBN	VBN	_	21	case	_	_
17	on	on	IN	IN	_	21	case	_	_
18	prior	prior	JJ	JJ	_	21	amod	_	_
19	in	in	FW	FW	_	21	amod	_	_
20	vitro	vitro	FW	FW	_	19	dep	_	_
21	studies	study	NNS	NNS	_	26	advcl	_	_
22	,	,	,	,	_	26	punct	_	_
23	is	be	VBZ	VBZ	_	26	auxpass	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	directly	directly	RB	RB	_	26	advmod	_	_
26	regulated	regulate	VBN	VBN	_	8	conj	_	_
27	by	by	IN	IN	_	30	case	_	_
28	I	i	NN	NN	_	30	compound	_	_
29	kappa	kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	28	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	critical	critical	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	interaction	interaction	NN	NN	_	5	nmod	_	_
11	between	between	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	I	i	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B/MAD-3	b/mad-3	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	28	punct	_	_
19	a	a	DT	DT	_	20	det	_	_
20	series	series	NN	NN	_	28	nsubjpass	_	_
21	of	of	IN	IN	_	26	case	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	p65	p65	NN	NN	_	26	compound	_	_
26	mutants	mutant	NNS	NNS	_	20	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	identified	identify	VBN	VBN	_	0	root	_	_
29	that	that	WDT	WDT	_	31	nsubj	_	_
30	functionally	functionally	RB	RB	_	31	advmod	_	_
31	segregated	segregate	VBD	VBD	_	28	ccomp	_	_
32	DNA	dna	NN	NN	_	33	compound	_	_
33	binding	binding	NN	NN	_	31	dobj	_	_
34	,	,	,	,	_	33	punct	_	_
35	I	i	NN	NN	_	37	nmod:npmod	_	_
36	kappa	kappa	NN	NN	_	37	nmod:npmod	_	_
37	B-mediated	b-mediated	JJ	JJ	_	38	amod	_	_
38	inhibition	inhibition	NN	NN	_	33	conj	_	_
39	,	,	,	,	_	33	punct	_	_
40	and	and	CC	CC	_	33	cc	_	_
41	I	i	NN	NN	_	43	nmod:npmod	_	_
42	kappa	kappa	NN	NN	_	43	nmod:npmod	_	_
43	B-induced	b-induced	JJ	JJ	_	45	amod	_	_
44	nuclear	nuclear	JJ	JJ	_	45	amod	_	_
45	exclusion	exclusion	NN	NN	_	33	conj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	this	this	DT	DT	_	49	det	_	_
48	transcription	transcription	NN	NN	_	49	compound	_	_
49	factor	factor	NN	NN	_	33	nmod	_	_
50	.	.	.	.	_	28	punct	_	_

1	Results	result	NNS	NNS	_	14	nsubj	_	_
2	from	from	IN	IN	_	6	case	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vivo	vivo	FW	FW	_	3	dep	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	studies	study	NNS	NNS	_	1	nmod	_	_
7	performed	perform	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	13	case	_	_
9	these	these	DT	DT	_	13	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	p65	p65	NN	NN	_	13	compound	_	_
13	mutants	mutant	NNS	NNS	_	7	nmod	_	_
14	revealed	reveal	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	following	following	NN	NN	_	14	dobj	_	_
17	:	:	:	:	_	14	punct	_	_
18	1	1	LS	LS	_	24	dep	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	I	i	NN	NN	_	22	compound	_	_
21	kappa	kappa	NN	NN	_	22	compound	_	_
22	B/MAD-3	b/mad-3	NN	NN	_	24	nsubj	_	_
23	completely	completely	RB	RB	_	24	advmod	_	_
24	inhibits	inhibit	VBZ	VBZ	_	14	parataxis	_	_
25	NF-kappa	nf-kappa	NN	NN	_	27	nmod:npmod	_	_
26	B	b	NN	NN	_	27	nmod:npmod	_	_
27	p65-dependent	p65-dependent	JJ	JJ	_	29	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	24	dobj	_	_
30	mediated	mediate	VBN	VBN	_	29	acl	_	_
31	through	through	IN	IN	_	40	case	_	_
32	the	the	DT	DT	_	40	det	_	_
33	human	human	JJ	JJ	_	40	amod	_	_
34	immunodeficiency	immunodeficiency	NN	NN	_	40	compound	_	_
35	virus	virus	NN	NN	_	40	compound	_	_
36	type	type	NN	NN	_	40	compound	_	_
37	1	1	CD	CD	_	40	nummod	_	_
38	kappa	kappa	NN	NN	_	40	compound	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	enhancer	enhancer	NN	NN	_	30	nmod	_	_
41	in	in	IN	IN	_	44	case	_	_
42	human	human	JJ	JJ	_	44	amod	_	_
43	T	t	NN	NN	_	44	compound	_	_
44	lymphocytes	lymphocyte	NNS	NNS	_	40	nmod	_	_
45	,	,	,	,	_	24	punct	_	_
46	2	2	LS	LS	_	59	dep	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	the	the	DT	DT	_	49	det	_	_
49	binding	binding	NN	NN	_	59	nsubj	_	_
50	of	of	IN	IN	_	53	case	_	_
51	I	i	NN	NN	_	53	compound	_	_
52	kappa	kappa	NN	NN	_	53	compound	_	_
53	B/MAD-3	b/mad-3	NN	NN	_	49	nmod	_	_
54	to	to	TO	TO	_	57	case	_	_
55	NF-kappa	nf-kappa	NN	NN	_	57	compound	_	_
56	B	b	NN	NN	_	57	compound	_	_
57	p65	p65	NN	NN	_	49	nmod	_	_
58	is	be	VBZ	VBZ	_	59	cop	_	_
59	sufficient	sufficient	JJ	JJ	_	24	ccomp	_	_
60	to	to	TO	TO	_	61	mark	_	_
61	retarget	retarget	VB	VB	_	59	xcomp	_	_
62	NF-kappa	nf-kappa	NN	NN	_	64	compound	_	_
63	B	b	NN	NN	_	64	compound	_	_
64	p65	p65	NN	NN	_	61	dobj	_	_
65	from	from	IN	IN	_	67	case	_	_
66	the	the	DT	DT	_	67	det	_	_
67	nucleus	nucleus	NN	NN	_	61	nmod	_	_
68	to	to	TO	TO	_	70	case	_	_
69	the	the	DT	DT	_	70	det	_	_
70	cytoplasm	cytoplasm	NN	NN	_	61	nmod	_	_
71	,	,	,	,	_	24	punct	_	_
72	3	3	LS	LS	_	92	dep	_	_
73	)	)	-RRB-	-RRB-	_	72	punct	_	_
74	selective	selective	JJ	JJ	_	75	amod	_	_
75	deletion	deletion	NN	NN	_	92	nsubj	_	_
76	of	of	IN	IN	_	81	case	_	_
77	the	the	DT	DT	_	81	det	_	_
78	functional	functional	JJ	JJ	_	81	amod	_	_
79	nuclear	nuclear	JJ	JJ	_	81	amod	_	_
80	localization	localization	NN	NN	_	81	compound	_	_
81	signal	signal	NN	NN	_	75	nmod	_	_
82	present	present	JJ	JJ	_	81	amod	_	_
83	in	in	IN	IN	_	87	case	_	_
84	the	the	DT	DT	_	87	det	_	_
85	Rel	rel	NN	NN	_	87	compound	_	_
86	homology	homology	NN	NN	_	87	compound	_	_
87	domain	domain	NN	NN	_	82	nmod	_	_
88	of	of	IN	IN	_	91	case	_	_
89	NF-kappa	nf-kappa	NN	NN	_	91	compound	_	_
90	B	b	NN	NN	_	91	compound	_	_
91	p65	p65	NN	NN	_	87	nmod	_	_
92	disrupts	disrupt	VBZ	VBZ	_	24	ccomp	_	_
93	its	its	PRP$	PRP$	_	94	nmod:poss	_	_
94	ability	ability	NN	NN	_	92	dobj	_	_
95	to	to	TO	TO	_	96	mark	_	_
96	engage	engage	VB	VB	_	94	acl	_	_
97	I	i	NN	NN	_	99	compound	_	_
98	kappa	kappa	NN	NN	_	99	compound	_	_
99	B/MAD-3	b/mad-3	NN	NN	_	96	dobj	_	_
100	,	,	,	,	_	24	punct	_	_
101	and	and	CC	CC	_	24	cc	_	_
102	4	4	LS	LS	_	111	dep	_	_
103	)	)	-RRB-	-RRB-	_	102	punct	_	_
104	the	the	DT	DT	_	106	det	_	_
105	unique	unique	JJ	JJ	_	106	amod	_	_
106	C-terminus	c-terminus	NN	NN	_	111	nsubj	_	_
107	of	of	IN	IN	_	110	case	_	_
108	NF-kappa	nf-kappa	NN	NN	_	110	compound	_	_
109	B	b	NN	NN	_	110	compound	_	_
110	p65	p65	NN	NN	_	106	nmod	_	_
111	attenuates	attenuate	VBZ	VBZ	_	24	conj	_	_
112	its	its	PRP$	PRP$	_	115	nmod:poss	_	_
113	own	own	JJ	JJ	_	115	amod	_	_
114	nuclear	nuclear	JJ	JJ	_	115	amod	_	_
115	localization	localization	NN	NN	_	111	dobj	_	_
116	and	and	CC	CC	_	111	cc	_	_
117	contains	contain	VBZ	VBZ	_	111	conj	_	_
118	sequences	sequence	NNS	NNS	_	117	dobj	_	_
119	that	that	WDT	WDT	_	121	nsubjpass	_	_
120	are	be	VBP	VBP	_	121	auxpass	_	_
121	required	require	VBN	VBN	_	118	acl:relcl	_	_
122	for	for	IN	IN	_	126	case	_	_
123	I	i	NN	NN	_	125	nmod:npmod	_	_
124	kappa	kappa	NN	NN	_	125	nmod:npmod	_	_
125	B-mediated	b-mediated	JJ	JJ	_	126	amod	_	_
126	inhibition	inhibition	NN	NN	_	121	nmod	_	_
127	of	of	IN	IN	_	133	case	_	_
128	NF-kappa	nf-kappa	NN	NN	_	133	compound	_	_
129	B	b	NN	NN	_	133	compound	_	_
130	p65	p65	NN	NN	_	133	compound	_	_
131	DNA	dna	NN	NN	_	133	compound	_	_
132	binding	binding	NN	NN	_	133	compound	_	_
133	activity	activity	NN	NN	_	126	nmod	_	_
134	.	.	.	.	_	24	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
9	localization	localization	NN	NN	_	10	compound	_	_
10	signal	signal	NN	NN	_	18	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	transactivation	transactivation	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	p65	p65	NN	NN	_	10	nmod	_	_
18	constitute	constitute	VBP	VBP	_	5	ccomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	bipartite	bipartite	JJ	JJ	_	21	amod	_	_
21	system	system	NN	NN	_	18	dobj	_	_
22	that	that	WDT	WDT	_	25	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	critically	critically	RB	RB	_	25	advmod	_	_
25	involved	involve	VBN	VBN	_	21	acl:relcl	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	inhibitory	inhibitory	JJ	JJ	_	29	amod	_	_
29	function	function	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	I	i	NN	NN	_	33	compound	_	_
32	kappa	kappa	NN	NN	_	33	compound	_	_
33	B/MAD-3	b/mad-3	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	studies	study	NNS	NNS	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	I	i	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B/MAD-3	b/mad-3	NN	NN	_	13	nsubj	_	_
13	binds	bind	VBZ	VBZ	_	8	ccomp	_	_
14	directly	directly	RB	RB	_	13	advmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	p50	p50	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	functional	functional	JJ	JJ	_	0	root	_	_
5	as	as	IN	IN	_	7	mark	_	_
6	it	it	PRP	PRP	_	7	nsubj	_	_
7	leads	lead	VBZ	VBZ	_	4	advcl	_	_
8	to	to	TO	TO	_	9	case	_	_
9	retargeting	retargeting	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	p50	p50	NN	NN	_	9	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nucleus	nucleus	NN	NN	_	9	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cytoplasm	cytoplasm	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	loss	loss	NN	NN	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	presumably	presumably	RB	RB	_	13	advmod	_	_
13	reflecting	reflect	VBG	VBG	_	10	xcomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	unique	unique	JJ	JJ	_	17	amod	_	_
16	C-terminal	c-terminal	JJ	JJ	_	17	amod	_	_
17	domain	domain	NN	NN	_	13	dobj	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	distinct	distinct	JJ	JJ	_	17	acl:relcl	_	_
21	from	from	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	present	present	JJ	JJ	_	22	amod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	p65	p65	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	Surrogate	surrogate	NN	NN	_	3	compound	_	_
2	thyroglobulin	thyroglobulin	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	proliferation	proliferation	NN	NN	_	3	conj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	Hashimoto	hashimoto	NN	NN	_	11	nmod:poss	_	_
10	's	's	POS	POS	_	9	case	_	_
11	thyroiditis	thyroiditis	NN	NN	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Immunoglobulin	immunoglobulin	NN	NN	_	2	compound	_	_
2	molecules	molecule	NNS	NNS	_	14	nsubj	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	surface	surface	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	lymphocyte	lymphocyte	NN	NN	_	5	nmod	_	_
10	are	be	VBP	VBP	_	14	cop	_	_
11	the	the	DT	DT	_	14	det	_	_
12	endogenous	endogenous	JJ	JJ	_	14	amod	_	_
13	``	``	``	``	_	14	punct	_	_
14	receptors	receptor	NNS	NNS	_	0	root	_	_
15	to	to	TO	TO	_	16	case	_	_
16	which	which	WDT	WDT	_	19	nmod	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	antigens	antigen	NNS	NNS	_	19	nsubj	_	_
19	bind	bind	VBP	VBP	_	14	acl:relcl	_	_
20	.	.	.	.	_	14	punct	_	_

1	Studies	study	NNS	NNS	_	5	nsubj	_	_
2	in	in	IN	IN	_	3	case	_	_
3	mice	mouse	NNS	NNS	_	1	nmod	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	a	a	DT	DT	_	9	det	_	_
8	monoclonal	monoclonal	JJ	JJ	_	9	amod	_	_
9	antibody	antibody	NN	NN	_	22	nsubjpass	_	_
10	,	,	,	,	_	9	punct	_	_
11	conjugated	conjugate	VBN	VBN	_	9	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	palmitate	palmitate	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	provide	provide	VB	VB	_	11	xcomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	lipid	lipid	NN	NN	_	18	compound	_	_
18	tail	tail	NN	NN	_	15	dobj	_	_
19	,	,	,	,	_	9	punct	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	inserted	insert	VBN	VBN	_	5	ccomp	_	_
23	into	into	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	membrane	membrane	NN	NN	_	22	nmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	provide	provide	VB	VB	_	22	xcomp	_	_
29	a	a	DT	DT	_	33	det	_	_
30	``	``	``	``	_	33	punct	_	_
31	surrogate	surrogate	JJ	JJ	_	33	amod	_	_
32	antigen	antigen	NN	NN	_	33	compound	_	_
33	receptor	receptor	NN	NN	_	28	dobj	_	_
34	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	whether	whether	IN	IN	_	20	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	palmitate	palmitate	JJ	JJ	_	7	amod	_	_
7	conjugate	conjugate	NN	NN	_	20	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monoclonal	monoclonal	JJ	JJ	_	12	amod	_	_
12	antibody	antibody	NN	NN	_	7	nmod	_	_
13	specific	specific	JJ	JJ	_	7	amod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	thyroglobulin	thyroglobulin	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TG	tg	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	function	function	VB	VB	_	3	ccomp	_	_
21	as	as	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	surrogate	surrogate	JJ	JJ	_	25	amod	_	_
24	TG	tg	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	20	nmod	_	_
26	on	on	IN	IN	_	29	case	_	_
27	blood	blood	NN	NN	_	29	compound	_	_
28	mononuclear	mononuclear	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	20	nmod	_	_
30	separated	separate	VBN	VBN	_	29	acl	_	_
31	into	into	IN	IN	_	32	case	_	_
32	fractions	fraction	NNS	NNS	_	30	nmod	_	_
33	enriched	enrich	VBN	VBN	_	32	dep	_	_
34	for	for	IN	IN	_	36	case	_	_
35	T	t	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	or	or	CC	CC	_	33	cc	_	_
38	depleted	deplete	VBN	VBN	_	33	conj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	(	(	-LRB-	-LRB-	_	44	punct	_	_
43	non-T	non-t	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	41	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	flow	flow	NN	NN	_	3	compound	_	_
3	cytometry	cytometry	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	detected	detect	VBD	VBD	_	0	root	_	_
7	surrogate	surrogate	JJ	JJ	_	9	amod	_	_
8	TG	tg	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	6	dobj	_	_
10	on	on	IN	IN	_	11	case	_	_
11	non-T	non-t	JJ	JJ	_	18	nmod	_	_
12	(	(	-LRB-	-LRB-	_	11	punct	_	_
13	but	but	CC	CC	_	11	cc	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	on	on	IN	IN	_	16	case	_	_
16	T	t	NN	NN	_	11	conj	_	_
17	)	)	-RRB-	-RRB-	_	11	punct	_	_
18	cells	cell	NNS	NNS	_	6	nmod	_	_
19	from	from	IN	IN	_	23	case	_	_
20	11	11	CD	CD	_	22	compound	_	_
21	of	of	IN	IN	_	22	advmod	_	_
22	11	11	CD	CD	_	23	nummod	_	_
23	individuals	individual	NNS	NNS	_	18	nmod	_	_
24	studied	study	VBN	VBN	_	23	acl	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	5	5	CD	CD	_	28	nummod	_	_
27	Hashimoto	hashimoto	NN	NN	_	28	compound	_	_
28	patients	patient	NNS	NNS	_	23	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	6	6	CD	CD	_	32	nummod	_	_
31	control	control	NN	NN	_	32	compound	_	_
32	donors	donor	NNS	NNS	_	28	conj	_	_
33	)	)	-RRB-	-RRB-	_	28	punct	_	_
34	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	endogenous	endogenous	JJ	JJ	_	6	amod	_	_
5	TG	tg	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	10	nsubjpass	_	_
7	could	could	MD	MD	_	10	aux	_	_
8	only	only	RB	RB	_	10	advmod	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	non-T	non-t	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	from	from	IN	IN	_	19	case	_	_
15	1	1	CD	CD	_	17	compound	_	_
16	of	of	IN	IN	_	17	advmod	_	_
17	3	3	CD	CD	_	19	nummod	_	_
18	Hashimoto	hashimoto	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	from	from	IN	IN	_	26	case	_	_
22	0	0	CD	CD	_	24	compound	_	_
23	of	of	IN	IN	_	24	advmod	_	_
24	4	4	CD	CD	_	26	nummod	_	_
25	control	control	NN	NN	_	26	compound	_	_
26	donors	donor	NNS	NNS	_	19	conj	_	_
27	.	.	.	.	_	10	punct	_	_

1	Because	because	IN	IN	_	5	case	_	_
2	of	of	IN	IN	_	1	mwe	_	_
3	the	the	DT	DT	_	5	det	_	_
4	efficient	efficient	JJ	JJ	_	5	amod	_	_
5	binding	binding	NN	NN	_	16	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	TG	tg	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	surrogate	surrogate	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	5	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	non-T	non-t	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	5	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	assessed	assess	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	ability	ability	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	such	such	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	present	present	VB	VB	_	18	acl	_	_
24	TG	tg	NN	NN	_	23	dobj	_	_
25	to	to	TO	TO	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	Proliferation	proliferation	NN	NN	_	7	nsubjpass	_	_
2	in	in	IN	IN	_	5	case	_	_
3	response	response	NN	NN	_	5	dep	_	_
4	to	to	TO	TO	_	5	case	_	_
5	TG	tg	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	17	case	_	_
12	only	only	RB	RB	_	15	advmod	_	_
13	1	1	CD	CD	_	15	compound	_	_
14	of	of	IN	IN	_	15	advmod	_	_
15	5	5	CD	CD	_	17	nummod	_	_
16	Hashimoto	hashimoto	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	10	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	low	low	JJ	JJ	_	3	amod	_	_
3	frequency	frequency	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	response	response	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	no	no	RB	RB	_	8	neg	_	_
8	different	different	JJ	JJ	_	0	root	_	_
9	from	from	IN	IN	_	10	case	_	_
10	that	that	DT	DT	_	8	nmod	_	_
11	previously	previously	RB	RB	_	12	advmod	_	_
12	detected	detect	VBN	VBN	_	10	acl	_	_
13	using	use	VBG	VBG	_	12	xcomp	_	_
14	cultures	culture	NNS	NNS	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	autologous	autologous	JJ	JJ	_	21	amod	_	_
20	dendritic	dendritic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	successful	successful	JJ	JJ	_	5	amod	_	_
5	generation	generation	NN	NN	_	14	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	surrogate	surrogate	JJ	JJ	_	8	amod	_	_
8	receptors	receptor	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	non-T	non-t	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	19	case	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	efficient	efficient	JJ	JJ	_	19	amod	_	_
18	TG	tg	NN	NN	_	19	compound	_	_
19	presentation	presentation	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	significance	significance	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	present	present	JJ	JJ	_	8	amod	_	_
8	study	study	NN	NN	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	0	root	_	_
10	that	that	IN	IN	_	21	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	21	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	the	the	DT	DT	_	18	det	_	_
17	antigen-presenting	antigen-presenting	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	appos	_	_
19	,	,	,	,	_	13	punct	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	likely	likely	JJ	JJ	_	9	ccomp	_	_
22	to	to	TO	TO	_	26	mark	_	_
23	be	be	VB	VB	_	26	cop	_	_
24	the	the	DT	DT	_	26	det	_	_
25	limiting	limit	VBG	VBG	_	26	amod	_	_
26	element	element	NN	NN	_	21	xcomp	_	_
27	in	in	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	T	t	NN	NN	_	32	compound	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	proliferative	proliferative	JJ	JJ	_	32	amod	_	_
32	response	response	NN	NN	_	26	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	TG	tg	NN	NN	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	other	other	JJ	JJ	_	38	amod	_	_
37	thyroid	thyroid	NN	NN	_	38	compound	_	_
38	autoantigens	autoantigen	NNS	NNS	_	34	conj	_	_
39	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	antigen	antigen	NN	NN	_	7	nsubj	_	_
6	2	2	CD	CD	_	5	nummod	_	_
7	interacts	interact	VBZ	VBZ	_	0	root	_	_
8	with	with	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	EBNA2	ebna2	NN	NN	_	11	nmod:npmod	_	_
11	responsive	responsive	JJ	JJ	_	12	amod	_	_
12	cis-element	cis-element	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	terminal	terminal	JJ	JJ	_	19	amod	_	_
16	protein	protein	NN	NN	_	19	compound	_	_
17	1	1	CD	CD	_	19	nummod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	EBNA2	ebna2	NN	NN	_	6	nsubj	_	_
6	acts	act	VBZ	VBZ	_	0	root	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activator	activator	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	cellular	cellular	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	viral	viral	JJ	JJ	_	12	conj	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	plays	play	VBZ	VBZ	_	6	conj	_	_
18	a	a	DT	DT	_	20	det	_	_
19	crucial	crucial	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	immortalization	immortalization	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	primary	primary	JJ	JJ	_	27	amod	_	_
27	B-cells	b-cell	NNS	NNS	_	23	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	EBV	ebv	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	previously	previously	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	EBNA2	ebna2	NN	NN	_	7	nsubj	_	_
7	transactivates	transactivate	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	promoters	promoter	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	latent	latent	JJ	JJ	_	14	amod	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	antigens	antigen	NNS	NNS	_	9	nmod	_	_
15	LMP	lmp	NN	NN	_	14	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	TP1	tp1	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	TP2	tp2	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoter	promoter	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TP1	tp1	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	chosen	choose	VBN	VBN	_	0	root	_	_
9	as	as	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	model	model	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	study	study	VB	VB	_	12	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	mechanism	mechanism	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	EBNA2	ebna2	NN	NN	_	20	nmod:npmod	_	_
20	mediated	mediated	JJ	JJ	_	21	amod	_	_
21	transactivation	transactivation	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	15	advcl	_	_
3	an	a	DT	DT	_	7	det	_	_
4	EBNA2	ebna2	NN	NN	_	5	nmod:npmod	_	_
5	dependent	dependent	JJ	JJ	_	7	amod	_	_
6	cis-acting	cis-acting	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	15	punct	_	_
9	various	various	JJ	JJ	_	13	amod	_	_
10	TP1	tp1	NN	NN	_	13	compound	_	_
11	promoter-reporter	promoter-reporter	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	constructs	construct	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	transfected	transfect	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	absence	absence	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	presence	presence	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	an	a	DT	DT	_	25	det	_	_
23	EBNA2	ebna2	NN	NN	_	25	compound	_	_
24	expression	expression	NN	NN	_	25	compound	_	_
25	vector	vector	NN	NN	_	18	nmod	_	_
26	into	into	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	established	established	JJ	JJ	_	31	amod	_	_
29	B-cell	b-cell	NN	NN	_	31	compound	_	_
30	line	line	NN	NN	_	31	compound	_	_
31	BL41-P3HR1	bl41-p3hr1	NN	NN	_	15	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	were	be	VBD	VBD	_	3	cop	_	_
3	able	able	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	delineate	delineate	VB	VB	_	3	xcomp	_	_
6	an	a	DT	DT	_	11	det	_	_
7	81	81	CD	CD	_	11	nummod	_	_
8	bp	bp	NN	NN	_	11	compound	_	_
9	EBNA2	ebna2	NN	NN	_	10	nmod:npmod	_	_
10	responsive	responsive	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	5	dobj	_	_
12	between	between	IN	IN	_	13	case	_	_
13	-258	-258	CD	CD	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-177	-177	CD	CD	_	13	conj	_	_
16	relative	relative	JJ	JJ	_	22	case	_	_
17	to	to	TO	TO	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	TP1	tp1	NN	NN	_	22	compound	_	_
20	RNA	rna	NN	NN	_	22	compound	_	_
21	start	start	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	3	nsubj	_	_
3	worked	work	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	either	either	DT	DT	_	6	det	_	_
6	orientation	orientation	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	could	could	MD	MD	_	9	aux	_	_
9	mediate	mediate	VB	VB	_	3	conj	_	_
10	EBNA2	ebna2	NN	NN	_	11	nmod:npmod	_	_
11	dependent	dependent	JJ	JJ	_	12	amod	_	_
12	transactivation	transactivation	NN	NN	_	9	dobj	_	_
13	on	on	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	heterologous	heterologous	JJ	JJ	_	16	amod	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	three	three	CD	CD	_	9	nummod	_	_
7	specific	specific	JJ	JJ	_	9	amod	_	_
8	protein-DNA	protein-dna	NN	NN	_	9	compound	_	_
9	complexes	complex	NNS	NNS	_	5	dobj	_	_
10	formed	form	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	sequences	sequence	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	EBNA2	ebna2	NN	NN	_	16	nmod:npmod	_	_
16	responsive	responsive	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Two	two	CD	CD	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	were	be	VBD	VBD	_	8	cop	_	_
5	not	not	RB	RB	_	8	neg	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	8	nmod:npmod	_	_
8	specific	specific	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	8	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	third	third	JJ	JJ	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	8	conj	_	_
15	only	only	RB	RB	_	20	advmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	EBNA2	ebna2	NN	NN	_	18	nmod:npmod	_	_
18	positive	positive	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	extracts	extract	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Gel-shift	gel-shift	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	11	nsubj	_	_
3	in	in	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	dep	_	_
5	presence	presence	NN	NN	_	10	dep	_	_
6	of	of	IN	IN	_	10	case	_	_
7	EBNA2	ebna2	NN	NN	_	8	nmod:npmod	_	_
8	specific	specific	JJ	JJ	_	10	amod	_	_
9	monoclonal	monoclonal	JJ	JJ	_	10	amod	_	_
10	antibodies	antibody	NNS	NNS	_	2	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	EBNA2	ebna2	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	component	component	NN	NN	_	11	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	third	third	JJ	JJ	_	20	amod	_	_
20	complex	complex	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	EBNA2	ebna2	NN	NN	_	8	nsubj	_	_
8	interacts	interact	VBZ	VBZ	_	5	ccomp	_	_
9	with	with	IN	IN	_	13	case	_	_
10	an	a	DT	DT	_	13	det	_	_
11	EBNA2	ebna2	NN	NN	_	12	nmod:npmod	_	_
12	responsive	responsive	JJ	JJ	_	13	amod	_	_
13	cis-element	cis-element	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	TP1	tp1	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	ras	ras	NN	NN	_	3	compound	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	11	case	_	_
7	T-cell	t-cell	NN	NN	_	11	compound	_	_
8	antigen	antigen	NN	NN	_	11	compound	_	_
9	receptor	receptor	NN	NN	_	11	compound	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	a	a	DT	DT	_	5	det	_	_
3	Jurkat	jurkat	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	model	model	NN	NN	_	15	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	an	a	DT	DT	_	13	det	_	_
10	interleukin-2	interleukin-2	NN	NN	_	13	compound	_	_
11	promoter/reporter	promoter/reporter	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	construct	construct	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	antigen	antigen	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	agonism	agonism	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	combination	combination	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	lymphokine	lymphokine	NN	NN	_	25	compound	_	_
25	interleukin-1	interleukin-1	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Antigen	antigen	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	signals	signal	NNS	NNS	_	6	nsubjpass	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	mimicked	mimic	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	suboptimal	suboptimal	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PKC	pkc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	esters	ester	NNS	NNS	_	9	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	combination	combination	NN	NN	_	6	nmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	calcium	calcium	NN	NN	_	24	compound	_	_
24	mobilization	mobilization	NN	NN	_	21	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	an	a	DT	DT	_	27	det	_	_
27	ionophore	ionophore	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	cotransfection	cotransfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	oncogenic	oncogenic	JJ	JJ	_	6	amod	_	_
6	rats	rat	NNS	NNS	_	7	nsubj	_	_
7	obviated	obviate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	need	need	NN	NN	_	7	dobj	_	_
10	for	for	IN	IN	_	12	case	_	_
11	PKC	pkc	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	9	nmod	_	_
13	but	but	CC	CC	_	7	cc	_	_
14	did	do	VBD	VBD	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	replace	replace	VB	VB	_	7	conj	_	_
17	either	either	CC	CC	_	20	cc:preconj	_	_
18	the	the	DT	DT	_	20	det	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	signal	signal	NN	NN	_	16	dobj	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	interleukin-1	interleukin-1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	ras	ras	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	replaced	replace	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	requirement	requirement	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	PKC	pkc	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	T-cell	t-cell	NN	NN	_	18	compound	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	NF-AT	nf-at	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	dominant	dominant	JJ	JJ	_	5	amod	_	_
3	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
4	ras	ras	NN	NN	_	5	compound	_	_
5	mutant	mutant	NN	NN	_	7	nsubj	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	blocked	block	VBD	VBD	_	0	root	_	_
8	antigen	antigen	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	agonism	agonism	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	indicating	indicate	VBG	VBG	_	7	advcl	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	ras	ras	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	12	ccomp	_	_
18	for	for	IN	IN	_	21	case	_	_
19	antigen	antigen	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	signaling	signaling	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	an	a	DT	DT	_	5	det	_	_
5	inhibitor	inhibitor	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PKC	pkc	NN	NN	_	5	nmod	_	_
8	blocked	block	VBD	VBD	_	0	root	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	activated	activate	VBD	VBD	_	11	amod	_	_
11	ras	ras	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	phorbol	phorbol	NN	NN	_	15	compound	_	_
14	ester	ester	NN	NN	_	15	compound	_	_
15	stimulation	stimulation	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
18	a	a	DT	DT	_	19	det	_	_
19	role	role	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	ras	ras	NN	NN	_	19	nmod	_	_
22	upstream	upstream	JJ	JJ	_	21	advmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	PKC	pkc	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cytoplasmic	cytoplasmic	JJ	JJ	_	4	conj	_	_
7	components	component	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	20	case	_	_
9	the	the	DT	DT	_	20	det	_	_
10	lymphoid-specific	lymphoid-specific	JJ	JJ	_	20	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	20	compound	_	_
13	of	of	IN	IN	_	16	case	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	NF-AT	nf-at	NN	NN	_	12	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	complex	complex	NN	NN	_	7	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	lymphoid-specific	lymphoid-specific	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	complex	complex	NN	NN	_	9	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	NF-AT	nf-at	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	early	early	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	assembled	assemble	VBN	VBN	_	9	conj	_	_
20	from	from	IN	IN	_	28	case	_	_
21	a	a	DT	DT	_	28	det	_	_
22	pre-existing	pre-existing	JJ	JJ	_	28	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cell	cell	NN	NN	_	26	nmod:npmod	_	_
26	restricted	restricted	JJ	JJ	_	22	dep	_	_
27	cytoplasmic	cytoplasmic	JJ	JJ	_	28	amod	_	_
28	factor	factor	NN	NN	_	19	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	an	a	DT	DT	_	34	det	_	_
31	inducible	inducible	JJ	JJ	_	34	amod	_	_
32	ubiquitous	ubiquitous	JJ	JJ	_	34	amod	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	component	component	NN	NN	_	28	conj	_	_
35	within	within	IN	IN	_	36	advmod	_	_
36	30	30	CD	CD	_	37	nummod	_	_
37	min	min	NN	NN	_	19	nmod	_	_
38	after	after	IN	IN	_	37	case	_	_
39	activation	activation	NN	NN	_	37	dep	_	_
40	through	through	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	antigen	antigen	NN	NN	_	43	compound	_	_
43	receptor	receptor	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	9	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	family	family	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	AP1	ap1	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	as	as	IN	IN	_	11	case	_	_
11	components	component	NNS	NNS	_	4	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	murine	murine	JJ	JJ	_	16	amod	_	_
15	NF-AT	nf-at	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Evidence	evidence	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	provided	provide	VBN	VBN	_	0	root	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	component	component	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	NF-AT	nf-at	NN	NN	_	8	nmod	_	_
12	contains	contain	VBZ	VBZ	_	3	ccomp	_	_
13	the	the	DT	DT	_	18	det	_	_
14	phorbol	phorbol	NN	NN	_	15	nmod:npmod	_	_
15	ester-inducible	ester-inducible	JJ	JJ	_	18	amod	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	AP1	ap1	NN	NN	_	12	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Jun/Fos	jun/fos	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	characterize	characterize	VBP	VBP	_	0	root	_	_
4	which	which	WDT	WDT	_	7	det	_	_
5	AP1	ap1	NN	NN	_	7	compound	_	_
6	family	family	NN	NN	_	7	compound	_	_
7	members	member	NNS	NNS	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	assume	assume	VB	VB	_	3	ccomp	_	_
10	this	this	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	Antisera	antisera	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	Fos	fos	NN	NN	_	1	nmod	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	NF-AT	nf-at	NN	NN	_	7	compound	_	_
6	DNA	dna	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	4	dobj	_	_
8	as	as	IN	IN	_	9	dep	_	_
9	does	do	VBZ	VBZ	_	4	advcl	_	_
10	an	a	DT	DT	_	11	det	_	_
11	oligonucleotide	oligonucleotide	NN	NN	_	9	nsubj	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	a	a	DT	DT	_	15	det	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	site	site	NN	NN	_	12	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	AP1	ap1	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	15	nsubj	_	_
3	in	in	FW	FW	_	4	compound	_	_
4	vivo	vivo	FW	FW	_	2	advmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Fos	fos	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	lesser	lesser	JJR	JJR	_	12	amod	_	_
12	extent	extent	NN	NN	_	13	nmod	_	_
13	Fra-1	fra-1	NN	NN	_	2	conj	_	_
14	,	,	,	,	_	2	punct	_	_
15	eliminates	eliminate	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	requirement	requirement	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	25	case	_	_
19	phorbol	phorbol	NN	NN	_	21	compound	_	_
20	12-myristate	12-myristate	NN	NN	_	21	compound	_	_
21	13-acetate	13-acetate	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PMA	pma	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	stimulation	stimulation	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	leaving	leave	VBG	VBG	_	15	advcl	_	_
28	NF-AT-directed	nf-at-directed	JJ	JJ	_	29	amod	_	_
29	transcription	transcription	NN	NN	_	30	nsubj	_	_
30	responsive	responsive	JJ	JJ	_	27	xcomp	_	_
31	to	to	TO	TO	_	33	case	_	_
32	calcium	calcium	NN	NN	_	33	compound	_	_
33	ionophore	ionophore	NN	NN	_	30	nmod	_	_
34	alone	alone	RB	RB	_	33	advmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	Overexpression	overexpression	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cJun	cjun	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	JunD	jund	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	3	cc	_	_
9	JunB	junb	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	eliminates	eliminate	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	requirement	requirement	NN	NN	_	12	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	PMA	pma	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	indicating	indicate	VBG	VBG	_	12	advcl	_	_
19	that	that	IN	IN	_	29	mark	_	_
20	many	many	JJ	JJ	_	27	amod	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	all	all	DT	DT	_	20	conj	_	_
24	Jun-	jun-	NN	NN	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Fos-related	fos-related	JJ	JJ	_	24	conj	_	_
27	proteins	protein	NNS	NNS	_	29	nsubj	_	_
28	functionally	functionally	RB	RB	_	29	advmod	_	_
29	activate	activate	VBP	VBP	_	18	ccomp	_	_
30	NF-AT-dependent	nf-at-dependent	JJ	JJ	_	31	amod	_	_
31	transcription	transcription	NN	NN	_	29	dobj	_	_
32	in	in	IN	IN	_	38	case	_	_
33	the	the	DT	DT	_	38	dep	_	_
34	presence	presence	NN	NN	_	38	dep	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	cytoplasmic	cytoplasmic	JJ	JJ	_	38	amod	_	_
38	component	component	NN	NN	_	29	nmod	_	_
39	.	.	.	.	_	12	punct	_	_

1	NF-AT	nf-at	NN	NN	_	3	compound	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	6	nsubjpass	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	reconstituted	reconstitute	VBN	VBN	_	0	root	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	6	advmod	_	_
9	using	use	VBG	VBG	_	6	xcomp	_	_
10	semi-purified	semi-purified	JJ	JJ	_	12	amod	_	_
11	AP1	ap1	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	dobj	_	_
13	mixed	mix	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	cytosol	cytosol	NN	NN	_	13	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
3	are	be	VBP	VBP	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	needed	need	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	reconstitution	reconstitution	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	although	although	IN	IN	_	15	mark	_	_
12	JunB	junb	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	functional	functional	JJ	JJ	_	19	advcl	_	_
16	,	,	,	,	_	19	punct	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	participate	participate	VB	VB	_	5	conj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	NF-AT	nf-at	NN	NN	_	25	compound	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	partially	partially	RB	RB	_	6	advmod	_	_
6	purified	purify	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-AT	nf-at	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	show	show	VBP	VBP	_	6	conj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	elution	elution	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	renaturation	renaturation	NN	NN	_	15	conj	_	_
18	from	from	IN	IN	_	22	case	_	_
19	SDS-polyacrylamide	sds-polyacrylamide	NN	NN	_	22	compound	_	_
20	gel	gel	NN	NN	_	22	compound	_	_
21	electrophoresis	electrophoresis	NN	NN	_	22	compound	_	_
22	gels	gel	NNS	NNS	_	15	nmod	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	it	it	PRP	PRP	_	25	nsubj	_	_
25	has	have	VBZ	VBZ	_	13	ccomp	_	_
26	a	a	DT	DT	_	28	det	_	_
27	molecular	molecular	JJ	JJ	_	28	amod	_	_
28	mass	mass	NN	NN	_	25	dobj	_	_
29	between	between	IN	IN	_	30	amod	_	_
30	94	94	CD	CD	_	33	nummod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	116	116	CD	CD	_	30	conj	_	_
33	kDa	kda	NN	NN	_	28	dep	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	may	may	MD	MD	_	36	aux	_	_
36	have	have	VB	VB	_	25	conj	_	_
37	multiple	multiple	JJ	JJ	_	40	amod	_	_
38	differentially	differentially	RB	RB	_	39	advmod	_	_
39	modified	modified	JJ	JJ	_	40	amod	_	_
40	forms	form	NNS	NNS	_	36	dobj	_	_
41	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	c-rel	c-rel	NN	NN	_	4	compound	_	_
3	protooncogene	protooncogene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	5	nsubj	_	_
5	represses	repress	VBZ	VBZ	_	0	root	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	nmod:npmod	_	_
7	B	b	NN	NN	_	8	nmod:npmod	_	_
8	p65-mediated	p65-mediated	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	5	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	repeat	repeat	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	type	type	NN	NN	_	21	compound	_	_
18	1	1	CD	CD	_	21	nummod	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	21	compound	_	_
21	virus	virus	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	long	long	JJ	JJ	_	4	amod	_	_
3	terminal	terminal	JJ	JJ	_	4	amod	_	_
4	repeat	repeat	NN	NN	_	37	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LTR	ltr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	type	type	NN	NN	_	14	compound	_	_
11	1	1	CD	CD	_	14	nummod	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	14	compound	_	_
14	virus	virus	NN	NN	_	4	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HIV-1	hiv-1	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	5'	5'	JJ	JJ	_	22	amod	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	4	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	gene	gene	NN	NN	_	22	nmod	_	_
26	encoding	encode	VBG	VBG	_	25	acl	_	_
27	the	the	DT	DT	_	32	det	_	_
28	interleukin	interleukin	NN	NN	_	32	compound	_	_
29	2	2	CD	CD	_	32	nummod	_	_
30	receptor	receptor	NN	NN	_	32	compound	_	_
31	alpha	alpha	NN	NN	_	32	compound	_	_
32	subunit	subunit	NN	NN	_	26	dobj	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	IL-2R	il-2r	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	share	share	NN	NN	_	0	root	_	_
38	functional	functional	JJ	JJ	_	42	amod	_	_
39	kappa	kappa	NN	NN	_	42	compound	_	_
40	B	b	NN	NN	_	42	compound	_	_
41	enhancer	enhancer	NN	NN	_	42	compound	_	_
42	elements	element	NNS	NNS	_	37	dobj	_	_
43	involved	involve	VBN	VBN	_	42	acl	_	_
44	in	in	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	regulation	regulation	NN	NN	_	43	nmod	_	_
47	of	of	IN	IN	_	51	case	_	_
48	these	these	DT	DT	_	51	det	_	_
49	inducible	inducible	JJ	JJ	_	51	amod	_	_
50	transcription	transcription	NN	NN	_	51	compound	_	_
51	units	unit	NNS	NNS	_	46	nmod	_	_
52	during	during	IN	IN	_	54	case	_	_
53	T-cell	t-cell	NN	NN	_	54	compound	_	_
54	activation	activation	NN	NN	_	46	nmod	_	_
55	.	.	.	.	_	37	punct	_	_

1	These	these	DT	DT	_	5	det	_	_
2	kappa	kappa	NN	NN	_	5	compound	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	enhancer	enhancer	NN	NN	_	5	compound	_	_
5	elements	element	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	recognized	recognize	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	structurally	structurally	RB	RB	_	11	advmod	_	_
11	related	related	JJ	JJ	_	12	amod	_	_
12	family	family	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	interactive	interactive	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	includes	include	VBZ	VBZ	_	12	acl:relcl	_	_
18	p50	p50	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	p65	p65	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	product	product	NN	NN	_	18	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	c-rel	c-rel	NN	NN	_	28	compound	_	_
28	protooncogene	protooncogene	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	c-Rel	c-rel	NN	NN	_	24	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	7	punct	_	_

1	Recent	recent	JJ	JJ	_	3	amod	_	_
2	biochemical	biochemical	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	p65	p65	NN	NN	_	10	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	p50	p50	NN	NN	_	7	conj	_	_
10	form	form	VBP	VBP	_	5	ccomp	_	_
11	the	the	DT	DT	_	15	det	_	_
12	prototypical	prototypical	JJ	JJ	_	15	amod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	10	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	rapidly	rapidly	RB	RB	_	20	advmod	_	_
20	translocated	translocate	VBN	VBN	_	15	acl:relcl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	cytoplasm	cytoplasm	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	nucleus	nucleus	NN	NN	_	20	nmod	_	_
27	during	during	IN	IN	_	29	case	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	20	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	intracellular	intracellular	JJ	JJ	_	4	amod	_	_
3	signaling	signaling	NN	NN	_	4	compound	_	_
4	complex	complex	NN	NN	_	6	nsubj	_	_
5	potently	potently	RB	RB	_	6	advmod	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	kappa	kappa	NN	NN	_	8	nmod:npmod	_	_
8	B-directed	b-directed	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	from	from	IN	IN	_	14	case	_	_
11	either	either	CC	CC	_	14	cc:preconj	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	LTR	ltr	NN	NN	_	9	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	IL-2R	il-2r	NN	NN	_	19	compound	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	14	conj	_	_
20	via	via	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	strong	strong	JJ	JJ	_	24	amod	_	_
23	transactivation	transactivation	NN	NN	_	24	compound	_	_
24	domain	domain	NN	NN	_	6	nmod	_	_
25	present	present	JJ	JJ	_	24	amod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	p65	p65	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	31	mark	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	31	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	c-Rel	c-rel	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	6	acl:relcl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	either	either	DT	DT	_	17	cc:preconj	_	_
16	phorbol	phorbol	NN	NN	_	17	compound	_	_
17	ester	ester	NN	NN	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	tumor	tumor	NN	NN	_	22	compound	_	_
20	necrosis	necrosis	NN	NN	_	22	compound	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	17	conj	_	_
23	with	with	IN	IN	_	25	case	_	_
24	delayed	delay	VBN	VBN	_	25	amod	_	_
25	kinetics	kinetics	NNS	NNS	_	13	nmod	_	_
26	relative	relative	JJ	JJ	_	25	amod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	p65	p65	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	6	punct	_	_
30	markedly	markedly	RB	RB	_	31	advmod	_	_
31	represses	repress	VBZ	VBZ	_	3	ccomp	_	_
32	p65-mediated	p65-mediated	JJ	JJ	_	33	amod	_	_
33	activation	activation	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	these	these	DT	DT	_	37	det	_	_
36	transcription	transcription	NN	NN	_	37	compound	_	_
37	units	unit	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	c-Rel	c-rel	NN	NN	_	3	nmod	_	_
6	correlate	correlate	VBP	VBP	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	with	with	IN	IN	_	15	case	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	10	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	heterodimerize	heterodimerize	VB	VB	_	15	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	p50	p50	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	c-Rel	c-rel	NN	NN	_	24	compound	_	_
24	inhibition	inhibition	NN	NN	_	25	nsubj	_	_
25	involves	involve	VBZ	VBZ	_	21	ccomp	_	_
26	competition	competition	NN	NN	_	25	dobj	_	_
27	with	with	IN	IN	_	28	case	_	_
28	p50/p65	p50/p65	NN	NN	_	26	nmod	_	_
29	for	for	IN	IN	_	30	case	_	_
30	occupancy	occupancy	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	kappa	kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	enhancer	enhancer	NN	NN	_	36	compound	_	_
36	element	element	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	one	one	CD	CD	_	8	nummod	_	_
8	function	function	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-Rel	c-rel	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	5	ccomp	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	physiologic	physiologic	JJ	JJ	_	15	amod	_	_
15	repressor	repressor	NN	NN	_	25	nmod	_	_
16	of	of	IN	IN	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
19	LTR	ltr	NN	NN	_	23	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-2R	il-2r	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	19	conj	_	_
23	promoters	promoter	NNS	NNS	_	15	nmod	_	_
24	,	,	,	,	_	25	punct	_	_
25	serving	serve	VBG	VBG	_	11	xcomp	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	efficiently	efficiently	RB	RB	_	28	advmod	_	_
28	counter	counter	VB	VB	_	25	xcomp	_	_
29	the	the	DT	DT	_	33	det	_	_
30	strong	strong	JJ	JJ	_	33	amod	_	_
31	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
32	activating	activating	JJ	JJ	_	33	amod	_	_
33	effects	effect	NNS	NNS	_	28	dobj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	p65	p65	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Protease	protease	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	2	nmod	_	_
6	distinguishes	distinguish	VBZ	VBZ	_	0	root	_	_
7	between	between	IN	IN	_	14	case	_	_
8	class	class	NN	NN	_	14	compound	_	_
9	II	ii	CD	CD	_	14	nummod	_	_
10	MHC	mhc	NN	NN	_	14	compound	_	_
11	X1	x1	NN	NN	_	14	compound	_	_
12	box	box	NN	NN	_	14	compound	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	6	nmod	_	_
15	in	in	IN	IN	_	21	case	_	_
16	wild-type	wild-type	JJ	JJ	_	21	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	class	class	NN	NN	_	19	nmod:npmod	_	_
19	II-deficient	ii-deficient	JJ	JJ	_	16	conj	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	X	x	NN	NN	_	4	compound	_	_
3	box	box	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	critical	critical	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	8	mark	_	_
8	directing	direct	VBG	VBG	_	6	advcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	17	case	_	_
12	class	class	NN	NN	_	17	compound	_	_
13	II	ii	CD	CD	_	17	nummod	_	_
14	major	major	JJ	JJ	_	17	amod	_	_
15	histocompatibility	histocompatibility	NN	NN	_	17	compound	_	_
16	complex	complex	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	11	mark	_	_
2	several	several	JJ	JJ	_	8	amod	_	_
3	class	class	NN	NN	_	8	compound	_	_
4	II	ii	CD	CD	_	8	nummod	_	_
5	promoter-specific	promoter-specific	JJ	JJ	_	8	amod	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	described	describe	VBN	VBN	_	22	advcl	_	_
12	,	,	,	,	_	22	punct	_	_
13	only	only	RB	RB	_	18	advmod	_	_
14	the	the	DT	DT	_	18	det	_	_
15	X	x	NN	NN	_	18	compound	_	_
16	box	box	NN	NN	_	18	compound	_	_
17	region	region	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	22	nsubj	_	_
19	,	,	,	,	_	18	punct	_	_
20	RFX	rfx	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	18	punct	_	_
22	shows	show	VBZ	VBZ	_	0	root	_	_
23	a	a	DT	DT	_	25	det	_	_
24	genetic	genetic	JJ	JJ	_	25	amod	_	_
25	correlation	correlation	NN	NN	_	22	dobj	_	_
26	with	with	IN	IN	_	29	case	_	_
27	class	class	NN	NN	_	29	compound	_	_
28	II	ii	CD	CD	_	29	nummod	_	_
29	expression	expression	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	22	punct	_	_
31	being	be	VBG	VBG	_	32	cop	_	_
32	deficient	deficient	JJ	JJ	_	22	advcl	_	_
33	in	in	IN	IN	_	37	case	_	_
34	some	some	DT	DT	_	37	det	_	_
35	B	b	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	32	nmod	_	_
38	derived	derive	VBN	VBN	_	37	acl	_	_
39	from	from	IN	IN	_	40	case	_	_
40	patients	patient	NNS	NNS	_	38	nmod	_	_
41	with	with	IN	IN	_	45	case	_	_
42	class	class	NN	NN	_	43	nmod:npmod	_	_
43	II-deficient	ii-deficient	JJ	JJ	_	45	amod	_	_
44	congenital	congenital	JJ	JJ	_	45	amod	_	_
45	immunodeficiency	immunodeficiency	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	22	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	evaluate	evaluate	VB	VB	_	25	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	X	x	NN	NN	_	10	compound	_	_
8	box	box	NN	NN	_	10	compound	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	class	class	NN	NN	_	15	compound	_	_
13	II	ii	CD	CD	_	15	nummod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	5	nmod	_	_
16	,	,	,	,	_	25	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	X	x	NN	NN	_	23	compound	_	_
22	box	box	NN	NN	_	23	compound	_	_
23	region	region	NN	NN	_	18	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	examined	examine	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	33	case	_	_
27	both	both	DT	DT	_	29	cc:preconj	_	_
28	class	class	NN	NN	_	29	nmod:npmod	_	_
29	II-positive	ii-positive	JJ	JJ	_	33	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	-negative	-negative	JJ	JJ	_	29	conj	_	_
32	lymphoid	lymphoid	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	9	case	_	_
2	addition	addition	NN	NN	_	9	dep	_	_
3	to	to	TO	TO	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	wild-type	wild-type	JJ	JJ	_	9	amod	_	_
6	B	b	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	line	line	NN	NN	_	9	compound	_	_
9	Raji	raji	NN	NN	_	35	nmod	_	_
10	,	,	,	,	_	35	punct	_	_
11	two	two	CD	CD	_	17	nummod	_	_
12	class	class	NN	NN	_	14	nmod:npmod	_	_
13	II	ii	CD	CD	_	14	compound	_	_
14	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
15	mutant	mutant	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	35	nsubjpass	_	_
18	,	,	,	,	_	17	punct	_	_
19	SJO	sjo	NN	NN	_	17	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	RJ2.2.5	rj2.2.5	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	Jurkat	jurkat	NN	NN	_	17	conj	_	_
25	,	,	,	,	_	24	punct	_	_
26	a	a	DT	DT	_	32	det	_	_
27	class	class	NN	NN	_	29	nmod:npmod	_	_
28	II	ii	CD	CD	_	29	compound	_	_
29	negative	negative	JJ	JJ	_	32	amod	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	line	line	NN	NN	_	24	appos	_	_
33	,	,	,	,	_	24	punct	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	examined	examine	VBN	VBN	_	0	root	_	_
36	.	.	.	.	_	35	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	contrast	contrast	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	wild-type	wild-type	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	neither	neither	DT	DT	_	17	nsubj	_	_
9	of	of	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	class	class	NN	NN	_	15	compound	_	_
12	II	ii	CD	CD	_	15	nummod	_	_
13	mutant	mutant	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	8	nmod	_	_
16	could	could	MD	MD	_	17	aux	_	_
17	use	use	VB	VB	_	0	root	_	_
18	the	the	DT	DT	_	21	det	_	_
19	X	x	NN	NN	_	21	compound	_	_
20	box	box	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	17	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	direct	direct	VB	VB	_	17	advcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	transiently	transiently	RB	RB	_	29	advmod	_	_
29	transfected	transfect	VBN	VBN	_	31	amod	_	_
30	reporter	reporter	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	25	nmod	_	_
32	,	,	,	,	_	17	punct	_	_
33	indicating	indicate	VBG	VBG	_	17	xcomp	_	_
34	that	that	IN	IN	_	41	mark	_	_
35	the	the	DT	DT	_	39	det	_	_
36	X	x	NN	NN	_	37	nmod:npmod	_	_
37	box-dependent	box-dependent	JJ	JJ	_	39	amod	_	_
38	transcriptional	transcriptional	JJ	JJ	_	39	amod	_	_
39	pathway	pathway	NN	NN	_	41	nsubj	_	_
40	is	be	VBZ	VBZ	_	41	cop	_	_
41	defective	defective	JJ	JJ	_	33	ccomp	_	_
42	in	in	IN	IN	_	44	case	_	_
43	these	these	DT	DT	_	44	det	_	_
44	cells	cell	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	X1	x1	NN	NN	_	10	compound	_	_
7	box	box	NN	NN	_	10	compound	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	RFX	rfx	NN	NN	_	3	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	examined	examine	VBN	VBN	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	found	find	VBN	VBN	_	12	conj	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	present	present	JJ	JJ	_	14	xcomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	wild-type	wild-type	JJ	JJ	_	21	amod	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	mutant	mutant	JJ	JJ	_	25	amod	_	_
25	RJ2.2.5	rj2.2.5	NN	NN	_	21	conj	_	_
26	but	but	CC	CC	_	12	cc	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	absent	absent	JJ	JJ	_	12	conj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	SJO	sjo	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	Jurkat	jurkat	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	other	other	JJ	JJ	_	6	amod	_	_
4	X1	x1	NN	NN	_	5	nmod:npmod	_	_
5	box-specific	box-specific	JJ	JJ	_	6	amod	_	_
6	activities	activity	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	all	all	DT	DT	_	13	det:predet	_	_
11	these	these	DT	DT	_	13	det	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	37	advcl	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	these	these	DT	DT	_	8	det	_	_
5	different	different	JJ	JJ	_	8	amod	_	_
6	X1	x1	NN	NN	_	8	compound	_	_
7	box	box	NN	NN	_	8	compound	_	_
8	activities	activity	NNS	NNS	_	9	nsubj	_	_
9	represented	represent	VBD	VBD	_	2	ccomp	_	_
10	distinct	distinct	JJ	JJ	_	13	amod	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	9	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	multimeric	multimeric	JJ	JJ	_	16	amod	_	_
16	forms	form	NNS	NNS	_	13	conj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	same	same	JJ	JJ	_	22	amod	_	_
20	factor	factor	NN	NN	_	22	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	s	s	NNS	NNS	_	16	nmod	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	37	punct	_	_
25	protease	protease	NN	NN	_	26	compound	_	_
26	treatment	treatment	NN	NN	_	37	nsubjpass	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	crude	crude	JJ	JJ	_	31	amod	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	extracts	extract	NNS	NNS	_	26	nmod	_	_
32	followed	follow	VBN	VBN	_	26	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	DNA-binding	dna-binding	JJ	JJ	_	35	amod	_	_
35	assays	assay	NNS	NNS	_	32	nmod	_	_
36	were	be	VBD	VBD	_	37	auxpass	_	_
37	carried	carry	VBN	VBN	_	0	root	_	_
38	out	out	RP	RP	_	37	compound:prt	_	_
39	and	and	CC	CC	_	37	cc	_	_
40	demonstrated	demonstrate	VBD	VBD	_	37	conj	_	_
41	that	that	IN	IN	_	45	mark	_	_
42	B	b	NN	NN	_	44	compound	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	extracts	extract	NNS	NNS	_	45	nsubj	_	_
45	contain	contain	VBP	VBP	_	40	ccomp	_	_
46	at	at	IN	IN	_	47	case	_	_
47	least	least	JJS	JJS	_	48	nmod:npmod	_	_
48	two	two	CD	CD	_	50	nummod	_	_
49	X1-specific	x1-specific	JJ	JJ	_	50	amod	_	_
50	factors	factor	NNS	NNS	_	45	dobj	_	_
51	.	.	.	.	_	37	punct	_	_

1	One	one	CD	CD	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	cleaved	cleave	VBN	VBN	_	5	amod	_	_
5	products	product	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	band	band	NN	NN	_	9	compound	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	pk	pk	NN	NN	_	1	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	correlates	correlate	VBZ	VBZ	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	RFX	rfx	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	comparison	comparison	NN	NN	_	11	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	protease-treated	protease-treated	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	prepared	prepare	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	10	case	_	_
9	Jurkat	jurkat	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	band	band	NN	NN	_	18	compound	_	_
17	1pk	1pk	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	13	nmod	_	_
19	despite	despite	IN	IN	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	absence	absence	NN	NN	_	11	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	native	native	JJ	JJ	_	26	amod	_	_
25	RFX	rfx	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	protease	protease	NN	NN	_	11	nsubj	_	_
5	treatment	treatment	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	analysis	analysis	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	SJO	sjo	NN	NN	_	10	compound	_	_
10	extracts	extract	NNS	NNS	_	4	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	no	no	DT	DT	_	14	neg	_	_
13	detectable	detectable	JJ	JJ	_	14	amod	_	_
14	levels	level	NNS	NNS	_	11	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	band	band	NN	NN	_	19	compound	_	_
18	1pk	1pk	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	multiple	multiple	JJ	JJ	_	9	amod	_	_
6	X1	x1	NN	NN	_	7	nmod:npmod	_	_
7	box-specific	box-specific	JJ	JJ	_	9	amod	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	activities	activity	NNS	NNS	_	10	nsubj	_	_
10	exist	exist	VBP	VBP	_	3	ccomp	_	_
11	in	in	IN	IN	_	14	case	_	_
12	all	all	DT	DT	_	14	det	_	_
13	lymphoid	lymphoid	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	but	but	CC	CC	_	3	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	presence	presence	NN	NN	_	25	nsubj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	an	a	DT	DT	_	24	det	_	_
21	actively	actively	RB	RB	_	22	advmod	_	_
22	binding	binding	NN	NN	_	24	amod	_	_
23	RFX	rfx	NN	NN	_	24	compound	_	_
24	species	species	NNS	NNS	_	18	nmod	_	_
25	correlates	correlate	VBZ	VBZ	_	3	conj	_	_
26	with	with	IN	IN	_	29	case	_	_
27	class	class	NN	NN	_	29	compound	_	_
28	II	ii	CD	CD	_	29	nummod	_	_
29	transcription	transcription	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Replication	replication	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	type	type	NN	NN	_	7	compound	_	_
4	1	1	CD	CD	_	7	nummod	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
7	viruses	virus	NNS	NNS	_	1	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	linker	linker	NN	NN	_	11	compound	_	_
10	substitution	substitution	NN	NN	_	11	compound	_	_
11	mutations	mutation	NNS	NNS	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	-201	-201	CD	CD	_	8	nmod	_	_
15	to	to	TO	TO	_	14	dep	_	_
16	-130	-130	CD	CD	_	14	dep	_	_
17	region	region	NN	NN	_	14	dep	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	long	long	JJ	JJ	_	22	amod	_	_
21	terminal	terminal	JJ	JJ	_	22	amod	_	_
22	repeat	repeat	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	previous	previous	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	analyses	analysis	NNS	NNS	_	14	nmod	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	11	det	_	_
7	chloramphenicol	chloramphenicol	JJ	JJ	_	11	amod	_	_
8	acetyltransferase	acetyltransferase	NN	NN	_	11	compound	_	_
9	reporter	reporter	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	system	system	NN	NN	_	5	dobj	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	determined	determine	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	47	mark	_	_
16	linker	linker	NN	NN	_	17	compound	_	_
17	substitution	substitution	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	LS	ls	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	mutations	mutation	NNS	NNS	_	47	nsubj	_	_
22	between	between	IN	IN	_	23	case	_	_
23	-201	-201	CD	CD	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	-130	-130	CD	CD	_	23	conj	_	_
26	(	(	-LRB-	-LRB-	_	23	punct	_	_
27	relative	relative	JJ	JJ	_	23	amod	_	_
28	to	to	TO	TO	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	transcription	transcription	NN	NN	_	32	compound	_	_
31	start	start	NN	NN	_	32	compound	_	_
32	site	site	NN	NN	_	27	nmod	_	_
33	)	)	-RRB-	-RRB-	_	23	punct	_	_
34	of	of	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	human	human	JJ	JJ	_	39	amod	_	_
37	immunodeficiency	immunodeficiency	NN	NN	_	39	compound	_	_
38	virus	virus	NN	NN	_	39	compound	_	_
39	type	type	NN	NN	_	23	nmod	_	_
40	1	1	CD	CD	_	39	nummod	_	_
41	long	long	JJ	JJ	_	43	amod	_	_
42	terminal	terminal	JJ	JJ	_	43	amod	_	_
43	repeat	repeat	NN	NN	_	39	dep	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	LTR	ltr	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	caused	cause	VBD	VBD	_	14	ccomp	_	_
48	moderate	moderate	JJ	JJ	_	49	amod	_	_
49	decreases	decrease	NNS	NNS	_	47	dobj	_	_
50	in	in	IN	IN	_	53	case	_	_
51	LTR	ltr	NN	NN	_	53	compound	_	_
52	transcriptional	transcriptional	JJ	JJ	_	53	amod	_	_
53	activity	activity	NN	NN	_	49	nmod	_	_
54	in	in	IN	IN	_	57	case	_	_
55	a	a	DT	DT	_	57	det	_	_
56	T-cell	t-cell	NN	NN	_	57	compound	_	_
57	line	line	NN	NN	_	53	nmod	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	S.L.Zeichner	S.L.Zeichner	NNP	NNP	_	14	dep	_	_
60	,	,	,	,	_	59	punct	_	_
61	J.Y.H.	J.Y.H.	NNP	NNP	_	62	compound	_	_
62	Kim	Kim	NNP	NNP	_	59	conj	_	_
63	,	,	,	,	_	59	punct	_	_
64	and	and	CC	CC	_	59	cc	_	_
65	J.C.Alwine	J.C.Alwine	NNP	NNP	_	59	conj	_	_
66	,	,	,	,	_	59	punct	_	_
67	J.Virol.	J.Virol.	NNP	NNP	_	59	appos	_	_
68	65	65	CD	CD	_	67	nummod	_	_
69	:	:	:	:	_	67	punct	_	_
70	2436-2444	2436-2444	CD	CD	_	67	nummod	_	_
71	,	,	,	,	_	59	punct	_	_
72	1991	1991	CD	CD	_	59	list	_	_
73	)	)	-RRB-	-RRB-	_	59	punct	_	_
74	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	confirm	confirm	VB	VB	_	18	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	significance	significance	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	region	region	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	context	context	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	viral	viral	JJ	JJ	_	15	amod	_	_
15	replication	replication	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	constructed	construct	VBD	VBD	_	0	root	_	_
19	several	several	JJ	JJ	_	18	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	these	these	DT	DT	_	23	det	_	_
22	LS	ls	NN	NN	_	23	compound	_	_
23	mutations	mutation	NNS	NNS	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	-201	-201	CD	CD	_	19	dep	_	_
26	to	to	TO	TO	_	25	dep	_	_
27	-184	-184	CD	CD	_	25	dep	_	_
28	,	,	,	,	_	25	punct	_	_
29	-183	-183	CD	CD	_	25	conj	_	_
30	to	to	TO	TO	_	29	dep	_	_
31	-166	-166	CD	CD	_	29	dep	_	_
32	,	,	,	,	_	25	punct	_	_
33	-165	-165	CD	CD	_	25	conj	_	_
34	to	to	TO	TO	_	33	dep	_	_
35	-148	-148	CD	CD	_	33	dep	_	_
36	,	,	,	,	_	25	punct	_	_
37	and	and	CC	CC	_	25	cc	_	_
38	-148	-148	CD	CD	_	25	conj	_	_
39	to	to	TO	TO	_	38	dep	_	_
40	-130	-130	CD	CD	_	38	dep	_	_
41	)	)	-RRB-	-RRB-	_	25	punct	_	_
42	in	in	IN	IN	_	43	case	_	_
43	proviruses	provirus	NNS	NNS	_	19	nmod	_	_
44	and	and	CC	CC	_	18	cc	_	_
45	prepared	prepare	VBD	VBD	_	18	conj	_	_
46	viral	viral	JJ	JJ	_	47	amod	_	_
47	stocks	stock	NNS	NNS	_	45	dobj	_	_
48	by	by	IN	IN	_	49	case	_	_
49	cocultivation	cocultivation	NN	NN	_	45	nmod	_	_
50	of	of	IN	IN	_	53	case	_	_
51	transfected	transfect	VBN	VBN	_	53	amod	_	_
52	RD	rd	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	49	nmod	_	_
54	with	with	IN	IN	_	56	case	_	_
55	CEMx174	cemx174	NN	NN	_	56	compound	_	_
56	cells	cell	NNS	NNS	_	49	nmod	_	_
57	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	mutations	mutation	NNS	NNS	_	16	nsubjpass	_	_
6	between	between	IN	IN	_	7	case	_	_
7	-93	-93	CD	CD	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	-76	-76	CD	CD	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	between	between	IN	IN	_	12	case	_	_
12	-75	-75	CD	CD	_	7	conj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	-58	-58	CD	CD	_	12	conj	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	utilized	utilize	VBN	VBN	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	since	since	IN	IN	_	20	mark	_	_
19	they	they	PRP	PRP	_	20	nsubj	_	_
20	affect	affect	VBP	VBP	_	16	advcl	_	_
21	the	the	DT	DT	_	33	det	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	33	amod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	-	-	:	:	_	25	punct	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	Sp1-binding	sp1-binding	JJ	JJ	_	25	conj	_	_
33	sites	site	NNS	NNS	_	20	dobj	_	_
34	and	and	CC	CC	_	20	cc	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	expected	expect	VBN	VBN	_	20	conj	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	diminish	diminish	VB	VB	_	36	xcomp	_	_
39	viral	viral	JJ	JJ	_	40	amod	_	_
40	replication	replication	NN	NN	_	38	dobj	_	_
41	.	.	.	.	_	16	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	30	mark	_	_
5	while	while	IN	IN	_	8	mark	_	_
6	transfection	transfection	NN	NN	_	7	compound	_	_
7	analyses	analysis	NNS	NNS	_	8	nsubj	_	_
8	offer	offer	VBP	VBP	_	30	advcl	_	_
9	an	a	DT	DT	_	11	det	_	_
10	adequate	adequate	JJ	JJ	_	11	amod	_	_
11	approximation	approximation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effects	effect	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	LS	ls	NN	NN	_	18	compound	_	_
18	mutations	mutation	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	30	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	analysis	analysis	NN	NN	_	30	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	replication	replication	NN	NN	_	21	nmod	_	_
25	using	use	VBG	VBG	_	24	acl	_	_
26	a	a	DT	DT	_	29	det	_	_
27	mutant	mutant	JJ	JJ	_	29	amod	_	_
28	viral	viral	JJ	JJ	_	29	amod	_	_
29	stock	stock	NN	NN	_	25	dobj	_	_
30	presents	present	VBZ	VBZ	_	3	ccomp	_	_
31	a	a	DT	DT	_	34	det	_	_
32	more	more	RBR	RBR	_	33	advmod	_	_
33	accurate	accurate	JJ	JJ	_	34	amod	_	_
34	picture	picture	NN	NN	_	30	dobj	_	_
35	,	,	,	,	_	34	punct	_	_
36	which	which	WDT	WDT	_	44	nsubj	_	_
37	is	be	VBZ	VBZ	_	44	cop	_	_
38	sometimes	sometimes	RB	RB	_	44	advmod	_	_
39	at	at	IN	IN	_	44	case	_	_
40	variance	variance	NN	NN	_	44	dep	_	_
41	with	with	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	transfection	transfection	NN	NN	_	44	compound	_	_
44	results	result	NNS	NNS	_	34	acl:relcl	_	_
45	.	.	.	.	_	3	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	mutants	mutant	NNS	NNS	_	14	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	-201/-184	-201/-184	CD	CD	_	5	nummod	_	_
5	NXS	nxs	NN	NN	_	2	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	-165/-148	-165/-148	CD	CD	_	8	nummod	_	_
8	NXS	nxs	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	-147/-130	-147/-130	CD	CD	_	12	nummod	_	_
12	NXS	nxs	NN	NN	_	5	conj	_	_
13	)	)	-RRB-	-RRB-	_	5	punct	_	_
14	had	have	VBD	VBD	_	0	root	_	_
15	effects	effect	NNS	NNS	_	14	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	replication	replication	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	23	nsubj	_	_
20	were	be	VBD	VBD	_	23	cop	_	_
21	much	much	RB	RB	_	22	advmod	_	_
22	more	more	RBR	RBR	_	23	advmod	_	_
23	severe	severe	JJ	JJ	_	14	dep	_	_
24	than	than	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	effects	effect	NNS	NNS	_	23	nmod	_	_
27	predicted	predict	VBN	VBN	_	26	acl	_	_
28	from	from	IN	IN	_	30	case	_	_
29	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
30	performance	performance	NN	NN	_	27	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	transfection	transfection	NN	NN	_	33	compound	_	_
33	analyses	analysis	NNS	NNS	_	30	nmod	_	_
34	,	,	,	,	_	14	punct	_	_
35	and	and	CC	CC	_	14	cc	_	_
36	the	the	DT	DT	_	37	det	_	_
37	effects	effect	NNS	NNS	_	51	nsubjpass	_	_
38	of	of	IN	IN	_	41	case	_	_
39	two	two	CD	CD	_	41	nummod	_	_
40	LS	ls	NN	NN	_	41	compound	_	_
41	mutations	mutation	NNS	NNS	_	37	nmod	_	_
42	(	(	-LRB-	-LRB-	_	44	punct	_	_
43	-201/-184	-201/-184	CD	CD	_	44	nummod	_	_
44	NXS	nxs	NN	NN	_	41	dep	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	-183/-166	-183/-166	CD	CD	_	47	nummod	_	_
47	NXS	nxs	NN	NN	_	44	conj	_	_
48	)	)	-RRB-	-RRB-	_	44	punct	_	_
49	were	be	VBD	VBD	_	51	auxpass	_	_
50	not	not	RB	RB	_	51	neg	_	_
51	predicted	predict	VBN	VBN	_	14	conj	_	_
52	by	by	IN	IN	_	54	case	_	_
53	their	they	PRP$	PRP$	_	54	nmod:poss	_	_
54	effects	effect	NNS	NNS	_	51	nmod	_	_
55	in	in	IN	IN	_	56	case	_	_
56	transfection	transfection	NN	NN	_	54	nmod	_	_
57	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	observed	observe	VBD	VBD	_	0	root	_	_
6	cell	cell	NN	NN	_	7	nmod:npmod	_	_
7	type-specific	type-specific	JJ	JJ	_	8	amod	_	_
8	permissiveness	permissiveness	NN	NN	_	5	dobj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	replication	replication	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	some	some	DT	DT	_	14	det	_	_
13	mutant	mutant	JJ	JJ	_	14	amod	_	_
14	viruses	virus	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	types	type	NNS	NNS	_	10	nmod	_	_
5	tested	test	VBN	VBN	_	4	acl	_	_
6	,	,	,	,	_	10	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	LS	ls	NN	NN	_	9	compound	_	_
9	mutations	mutation	NNS	NNS	_	10	nsubj	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	13	det	_	_
12	apparent	apparent	JJ	JJ	_	13	amod	_	_
13	requirement	requirement	NN	NN	_	10	dobj	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	only	only	RB	RB	_	23	cc:preconj	_	_
16	for	for	IN	IN	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	intact	intact	JJ	JJ	_	23	amod	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	SP1-binding	sp1-binding	JJ	JJ	_	20	conj	_	_
23	sites	site	NNS	NNS	_	13	nmod	_	_
24	but	but	CC	CC	_	23	cc	_	_
25	also	also	RB	RB	_	28	advmod	_	_
26	for	for	IN	IN	_	28	case	_	_
27	several	several	JJ	JJ	_	28	amod	_	_
28	regions	region	NNS	NNS	_	23	conj	_	_
29	between	between	IN	IN	_	30	case	_	_
30	-201	-201	CD	CD	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	-130	-130	CD	CD	_	30	conj	_	_
33	not	not	RB	RB	_	35	neg	_	_
34	previously	previously	RB	RB	_	35	advmod	_	_
35	associated	associate	VBN	VBN	_	28	acl	_	_
36	with	with	IN	IN	_	38	case	_	_
37	viral	viral	JJ	JJ	_	38	amod	_	_
38	infectivity	infectivity	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Dimerization	dimerization	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-KB2	nf-kb2	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	RelA(p65)	rela(p65)	NN	NN	_	1	nmod	_	_
6	regulates	regulate	VBZ	VBZ	_	0	root	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	inhibition	inhibition	NN	NN	_	8	conj	_	_
15	by	by	IN	IN	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B-alpha	b-alpha	NN	NN	_	6	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MAD-3	mad-3	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	6	punct	_	_

1	Inducible	inducible	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	virus	virus	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV	hiv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	kappa	kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	16	appos	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	11	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	composed	compose	VBN	VBN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	distinct	distinct	JJ	JJ	_	7	amod	_	_
7	subunits	subunit	NNS	NNS	_	4	nmod	_	_
8	;	;	:	:	_	4	punct	_	_
9	five	five	CD	CD	_	11	nummod	_	_
10	independent	independent	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	36	nsubjpass	_	_
12	,	,	,	,	_	11	punct	_	_
13	NFKB1(p105)	nfkb1(p105)	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	13	punct	_	_
15	NFKB2(p100)	nfkb2(p100)	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	RelA(p65)	rela(p65)	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	c-rel	c-rel	NN	NN	_	13	conj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	relB	relb	NN	NN	_	13	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	encode	encode	VBP	VBP	_	11	acl:relcl	_	_
25	related	related	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	24	dobj	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	bind	bind	VBP	VBP	_	26	acl:relcl	_	_
29	to	to	TO	TO	_	33	case	_	_
30	kappa	kappa	NN	NN	_	33	compound	_	_
31	B	b	NN	NN	_	33	compound	_	_
32	DNA	dna	NN	NN	_	33	compound	_	_
33	elements	element	NNS	NNS	_	28	nmod	_	_
34	have	have	VBP	VBP	_	36	aux	_	_
35	been	be	VBN	VBN	_	36	auxpass	_	_
36	isolated	isolate	VBN	VBN	_	4	parataxis	_	_
37	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	NFKB2(p49/p52)	nfkb2(p49/p52)	NN	NN	_	7	nsubj	_	_
7	acts	act	VBZ	VBZ	_	4	ccomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	concert	concert	NN	NN	_	11	dep	_	_
10	with	with	IN	IN	_	11	case	_	_
11	RelA(p65)	rela(p65)	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	stimulate	stimulate	VB	VB	_	7	xcomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	HIV	hiv	NN	NN	_	16	compound	_	_
16	enhancer	enhancer	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	Jurkat	jurkat	NN	NN	_	19	dep	_	_
19	T-leukemia	t-leukemia	NN	NN	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	examine	examine	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	biochemical	biochemical	JJ	JJ	_	6	amod	_	_
6	basis	basis	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	regulation	regulation	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HIV	hiv	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	NFKB2	nfkb2	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	7	advcl	_	_
2	Scatchard	scatchard	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	determined	determine	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	dissociation	dissociation	NN	NN	_	10	compound	_	_
10	constants	constant	NNS	NNS	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	homodimeric	homodimeric	JJ	JJ	_	13	amod	_	_
13	p49	p49	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	heterodimeric	heterodimeric	JJ	JJ	_	16	amod	_	_
16	p49/p65	p49/p65	NN	NN	_	13	conj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	binding	binding	NN	NN	_	10	acl	_	_
19	to	to	TO	TO	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	HIV	hiv	NN	NN	_	24	compound	_	_
22	kappa	kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	p49	p49	NN	NN	_	2	nsubj	_	_
2	has	have	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	approximately	approximately	RB	RB	_	5	advmod	_	_
5	18-fold-lower	18-fold-lower	JJ	JJ	_	6	amod	_	_
6	affinity	affinity	NN	NN	_	2	dobj	_	_
7	for	for	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	HIV	hiv	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	KD	kd	NN	NN	_	15	nsubj	_	_
15	=	=	JJ	JJ	_	6	dep	_	_
16	69.1	69.1	CD	CD	_	17	nummod	_	_
17	pM	pm	NN	NN	_	15	dobj	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	than	than	IN	IN	_	20	dep	_	_
20	does	do	VBZ	VBZ	_	6	dep	_	_
21	the	the	DT	DT	_	24	det	_	_
22	approximately	approximately	RB	RB	_	23	advmod	_	_
23	50-kDa	50-kda	JJ	JJ	_	24	amod	_	_
24	protein	protein	NN	NN	_	20	nsubj	_	_
25	NFKB1(p50)	nfkb1(p50)	NN	NN	_	24	dep	_	_
26	derived	derive	VBN	VBN	_	24	acl	_	_
27	from	from	IN	IN	_	28	case	_	_
28	p105	p105	NN	NN	_	26	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	KD	kd	NN	NN	_	31	nsubj	_	_
31	=	=	JJ	JJ	_	24	dep	_	_
32	3.9	3.9	CD	CD	_	33	nummod	_	_
33	pM	pm	NN	NN	_	31	dobj	_	_
34	)	)	-RRB-	-RRB-	_	31	punct	_	_
35	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	affinity	affinity	NN	NN	_	15	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	heterodimeric	heterodimeric	JJ	JJ	_	8	amod	_	_
8	NFKB2(p49)/RelA(p65)	nfkb2(p49)/rela(p65)	NN	NN	_	5	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	site	site	NN	NN	_	5	nmod	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	approximately	approximately	RB	RB	_	15	advmod	_	_
14	6-fold	6-fold	RB	RB	_	15	advmod	_	_
15	higher	higher	JJR	JJR	_	0	root	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	KD	kd	NN	NN	_	18	nsubj	_	_
18	=	=	JJ	JJ	_	15	dep	_	_
19	11.8	11.8	CD	CD	_	20	nummod	_	_
20	pM	pm	NN	NN	_	18	dobj	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	than	than	IN	IN	_	23	case	_	_
23	that	that	DT	DT	_	15	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	p49	p49	NN	NN	_	23	nmod	_	_
26	alone	alone	RB	RB	_	23	advmod	_	_
27	.	.	.	.	_	15	punct	_	_

1	Consistent	consistent	JJ	JJ	_	10	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	in	in	FW	FW	_	8	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	transcription	transcription	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	stimulated	stimulate	VBN	VBN	_	0	root	_	_
11	18-fold	18-fold	RB	RB	_	10	advmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	addition	addition	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	preformed	preformed	JJ	JJ	_	20	amod	_	_
17	,	,	,	,	_	16	punct	_	_
18	heterodimeric	heterodimeric	JJ	JJ	_	16	dep	_	_
19	NFKB2(p49)/RelA(p65)	nfkb2(p49)/rela(p65)	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	enhancer	enhancer	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	subject	subject	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	regulation	regulation	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	cloned	clone	VBN	VBN	_	17	amod	_	_
15	I	i	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B-alpha	b-alpha	NN	NN	_	11	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	MAD-3	mad-3	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	9	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	4	amod	_	_
2	I	i	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B-alpha	b-alpha	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	MAD-3	mad-3	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	p65	p65	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	p49/p65	p49/p65	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	p50/p65	p50/p65	NN	NN	_	14	conj	_	_
20	but	but	CC	CC	_	8	cc	_	_
21	stimulated	stimulate	VBD	VBD	_	8	conj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	binding	binding	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	NFKB2(p49)	nfkb2(p49)	NN	NN	_	23	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	NFKB1(p50)	nfkb1(p50)	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	8	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	an	a	DT	DT	_	7	det	_	_
5	HIV	hiv	NN	NN	_	7	compound	_	_
6	reporter	reporter	NN	NN	_	7	compound	_	_
7	plasmid	plasmid	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	p49/p65	p49/p65	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	transiently	transiently	RB	RB	_	12	advmod	_	_
12	transfected	transfect	VBN	VBN	_	15	amod	_	_
13	Jurkat	jurkat	NN	NN	_	14	nmod:npmod	_	_
14	T-leukemia	t-leukemia	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	2	nmod	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	inhibited	inhibit	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	20	case	_	_
20	coexpression	coexpression	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	MAD-3	mad-3	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	18	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	prointerleukin	prointerleukin	NN	NN	_	6	compound	_	_
4	1	1	CD	CD	_	6	nummod	_	_
5	beta	beta	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	7	nsubj	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	sequences	sequence	NNS	NNS	_	7	dobj	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	proximal	proximal	JJ	JJ	_	9	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	distal	distal	JJ	JJ	_	11	conj	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	start	start	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	11	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	tissue-specific	tissue-specific	JJ	JJ	_	21	amod	_	_
21	induction	induction	NN	NN	_	7	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	studies	study	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	sequences	sequence	NNS	NNS	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	interactions	interaction	NNS	NNS	_	9	conj	_	_
14	necessary	necessary	JJ	JJ	_	9	amod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	28	case	_	_
19	the	the	DT	DT	_	28	det	_	_
20	human	human	JJ	JJ	_	28	amod	_	_
21	prointerleukin	prointerleukin	NN	NN	_	23	compound	_	_
22	1	1	CD	CD	_	23	nummod	_	_
23	beta	beta	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	proIL-1	proil-1	NN	NN	_	26	compound	_	_
26	beta	beta	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	gene	gene	NN	NN	_	17	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	9	det	_	_
2	cell-type-independent	cell-type-independent	JJ	JJ	_	9	amod	_	_
3	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nmod:npmod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	LPS	lps	NN	NN	_	7	nmod:npmod	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	-responsive	-responsive	JJ	JJ	_	9	amod	_	_
8	enhancer	enhancer	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	26	nsubj	_	_
10	located	located	JJ	JJ	_	9	amod	_	_
11	between	between	IN	IN	_	15	case	_	_
12	-3757	-3757	CD	CD	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	-2729	-2729	CD	CD	_	12	conj	_	_
15	bp	bp	NN	NN	_	10	nmod	_	_
16	upstream	upstream	RB	RB	_	10	advmod	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	start	start	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	cap	cap	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	consisted	consist	VBD	VBD	_	0	root	_	_
27	of	of	IN	IN	_	32	case	_	_
28	at	at	IN	IN	_	29	case	_	_
29	least	least	JJS	JJS	_	30	nmod:npmod	_	_
30	six	six	CD	CD	_	32	nummod	_	_
31	discrete	discrete	JJ	JJ	_	32	amod	_	_
32	subregions	subregion	NNS	NNS	_	26	nmod	_	_
33	which	which	WDT	WDT	_	35	nsubj	_	_
34	were	be	VBD	VBD	_	35	cop	_	_
35	essential	essential	JJ	JJ	_	32	acl:relcl	_	_
36	to	to	TO	TO	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	maximal	maximal	JJ	JJ	_	39	amod	_	_
39	induction	induction	NN	NN	_	35	nmod	_	_
40	by	by	IN	IN	_	41	case	_	_
41	LPS	lps	NN	NN	_	39	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	transfected	transfect	VBN	VBN	_	44	amod	_	_
44	monocytes	monocyte	NNS	NNS	_	39	nmod	_	_
45	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	appeared	appear	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	mediate	mediate	VB	VB	_	4	xcomp	_	_
7	phorbol	phorbol	NN	NN	_	10	compound	_	_
8	myristate	myristate	NN	NN	_	10	compound	_	_
9	acetate	acetate	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	IL-1	il-1	NN	NN	_	15	compound	_	_
15	responsiveness	responsiveness	NN	NN	_	10	conj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Deletion	deletion	NN	NN	_	11	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	base	base	NN	NN	_	5	compound	_	_
4	substitution	substitution	NN	NN	_	5	compound	_	_
5	mutations	mutation	NNS	NNS	_	1	conj	_	_
6	along	along	IN	IN	_	1	cc	_	_
7	with	with	IN	IN	_	6	dep	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	studies	study	NNS	NNS	_	1	conj	_	_
11	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	enhancer	enhancer	NN	NN	_	15	nsubj	_	_
15	contained	contain	VBD	VBD	_	11	ccomp	_	_
16	a	a	DT	DT	_	17	det	_	_
17	minimum	minimum	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	23	case	_	_
19	three	three	CD	CD	_	23	nummod	_	_
20	functional	functional	JJ	JJ	_	23	amod	_	_
21	protein	protein	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sequences	sequence	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	two	two	CD	CD	_	28	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	which	which	WDT	WDT	_	25	nmod	_	_
28	appeared	appear	VBD	VBD	_	23	acl:relcl	_	_
29	to	to	TO	TO	_	31	mark	_	_
30	be	be	VB	VB	_	31	cop	_	_
31	important	important	JJ	JJ	_	28	xcomp	_	_
32	for	for	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	induction	induction	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	One	one	CD	CD	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	essential	essential	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	bound	bind	VBD	VBD	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	enhancer	enhancer	NN	NN	_	7	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	similar	similar	JJ	JJ	_	0	root	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	identical	identical	JJ	JJ	_	12	conj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	members	member	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	C/EBP	c/ebp	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	20	nmod	_	_
24	required	require	VBN	VBN	_	23	acl	_	_
25	for	for	IN	IN	_	30	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	IL-1-	il-1-	NN	NN	_	30	amod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	LPS-specific	lps-specific	JJ	JJ	_	27	conj	_	_
30	induction	induction	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	IL-6	il-6	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	40	punct	_	_
36	i.e.	i.e.	FW	FW	_	40	advmod	_	_
37	,	,	,	,	_	40	punct	_	_
38	the	the	DT	DT	_	40	det	_	_
39	NF-IL6	nf-il6	NN	NN	_	40	compound	_	_
40	proteins	protein	NNS	NNS	_	34	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	.	.	.	.	_	12	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	ligated	ligate	VBN	VBN	_	29	advcl	_	_
3	to	to	TO	TO	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	proIL-1	proil-1	NN	NN	_	9	compound	_	_
6	beta	beta	NN	NN	_	9	compound	_	_
7	cap	cap	NN	NN	_	8	nmod:npmod	_	_
8	site-proximal	site-proximal	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	2	nmod	_	_
10	(	(	-LRB-	-LRB-	_	9	punct	_	_
11	located	located	JJ	JJ	_	9	amod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	-131	-131	CD	CD	_	11	nmod	_	_
14	to	to	TO	TO	_	13	dep	_	_
15	+12	+12	CD	CD	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	9	punct	_	_
17	,	,	,	,	_	29	punct	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	proIL-1	proil-1	NN	NN	_	21	compound	_	_
21	beta	beta	NN	NN	_	29	nsubj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	28	det	_	_
24	simian	simian	JJ	JJ	_	28	amod	_	_
25	virus	virus	NN	NN	_	28	compound	_	_
26	40	40	CD	CD	_	28	nummod	_	_
27	enhancer	enhancer	NN	NN	_	28	compound	_	_
28	elements	element	NNS	NNS	_	21	conj	_	_
29	functioned	function	VBD	VBD	_	0	root	_	_
30	more	more	RBR	RBR	_	31	advmod	_	_
31	efficiently	efficiently	RB	RB	_	29	advmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	monocytes	monocyte	NNS	NNS	_	29	nmod	_	_
34	than	than	IN	IN	_	37	case	_	_
35	in	in	IN	IN	_	37	case	_	_
36	HeLa	hela	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	29	advcl	_	_
38	,	,	,	,	_	37	punct	_	_
39	which	which	WDT	WDT	_	43	nsubj	_	_
40	are	be	VBP	VBP	_	43	cop	_	_
41	not	not	RB	RB	_	43	neg	_	_
42	normally	normally	RB	RB	_	43	advmod	_	_
43	competent	competent	JJ	JJ	_	37	acl:relcl	_	_
44	for	for	IN	IN	_	47	case	_	_
45	IL-1	il-1	NN	NN	_	47	compound	_	_
46	beta	beta	NN	NN	_	47	compound	_	_
47	expression	expression	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	29	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	ligated	ligate	VBN	VBN	_	16	advcl	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	murine	murine	JJ	JJ	_	7	amod	_	_
6	c-fos	c-fos	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	however	however	RB	RB	_	16	advmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	the	the	DT	DT	_	14	det	_	_
12	proIL-1	proil-1	NN	NN	_	14	compound	_	_
13	beta	beta	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	inducible	inducible	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	22	case	_	_
18	phorbol	phorbol	NN	NN	_	20	nmod:npmod	_	_
19	myristate	myristate	NN	NN	_	20	nmod:npmod	_	_
20	acetate-stimulated	acetate-stimulated	JJ	JJ	_	22	amod	_	_
21	HeLa	hela	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	suggesting	suggest	VBG	VBG	_	16	xcomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	existence	existence	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	proIL-1	proil-1	NN	NN	_	31	nmod:npmod	_	_
30	beta	beta	NN	NN	_	31	nmod:npmod	_	_
31	promoter-proximal	promoter-proximal	JJ	JJ	_	32	amod	_	_
32	requirement	requirement	NN	NN	_	26	nmod	_	_
33	for	for	IN	IN	_	35	case	_	_
34	tissue	tissue	NN	NN	_	35	compound	_	_
35	specificity	specificity	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	Expression	expression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PILOT	pilot	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	8	det	_	_
6	putative	putative	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	3	appos	_	_
9	,	,	,	,	_	3	punct	_	_
10	requires	require	VBZ	VBZ	_	0	root	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	signals	signal	NNS	NNS	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	cyclosporin	cyclosporin	NN	NN	_	16	compound	_	_
16	A	a	NN	NN	_	17	nmod:npmod	_	_
17	sensitive	sensitive	JJ	JJ	_	10	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	10	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Few	few	JJ	JJ	_	3	amod	_	_
2	known	known	JJ	JJ	_	3	amod	_	_
3	genes	gene	NNS	NNS	_	16	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL-2	il-2	NN	NN	_	3	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	members	member	NNS	NNS	_	5	appos	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-8	il-8	NN	NN	_	11	compound	_	_
11	family	family	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	interferon-gamma	interferon-gamma	NN	NN	_	5	appos	_	_
14	)	)	-RRB-	-RRB-	_	5	punct	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	only	only	RB	RB	_	24	advmod	_	_
21	through	through	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	combined	combined	JJ	JJ	_	24	amod	_	_
24	effect	effect	NN	NN	_	16	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	phorbol	phorbol	NN	NN	_	28	compound	_	_
27	myristic	myristic	JJ	JJ	_	28	amod	_	_
28	acetate	acetate	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PMA	pma	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	a	a	DT	DT	_	34	det	_	_
34	Ca(2+)-ionophore	ca(2+)-ionophore	NN	NN	_	28	conj	_	_
35	,	,	,	,	_	16	punct	_	_
36	and	and	CC	CC	_	16	cc	_	_
37	expression	expression	NN	NN	_	45	nsubjpass	_	_
38	of	of	IN	IN	_	41	case	_	_
39	only	only	RB	RB	_	41	advmod	_	_
40	these	these	DT	DT	_	41	det	_	_
41	genes	gene	NNS	NNS	_	37	nmod	_	_
42	can	can	MD	MD	_	45	aux	_	_
43	be	be	VB	VB	_	45	auxpass	_	_
44	fully	fully	RB	RB	_	45	advmod	_	_
45	suppressed	suppress	VBN	VBN	_	16	conj	_	_
46	by	by	IN	IN	_	48	case	_	_
47	Cyclosporin	cyclosporin	NN	NN	_	48	compound	_	_
48	A	a	NN	NN	_	45	nmod	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	CyA	cya	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	putative	putative	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	designated	designate	VBN	VBN	_	7	acl	_	_
10	PILOT	pilot	NN	NN	_	9	xcomp	_	_
11	,	,	,	,	_	7	punct	_	_
12	with	with	IN	IN	_	17	case	_	_
13	an	a	DT	DT	_	17	det	_	_
14	identical	identical	JJ	JJ	_	17	amod	_	_
15	dual	dual	JJ	JJ	_	17	amod	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	requirement	requirement	NN	NN	_	7	nmod	_	_
18	for	for	IN	IN	_	19	case	_	_
19	expression	expression	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PILOT	pilot	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	detectable	detectable	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	20	20	CD	CD	_	13	nummod	_	_
13	min	min	NN	NN	_	7	nmod	_	_
14	following	follow	VBG	VBG	_	13	dep	_	_
15	activation	activation	NN	NN	_	13	dep	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	dep	_	_
18	presence	presence	NN	NN	_	20	dep	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cycloheximide	cycloheximide	NN	NN	_	7	nmod	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	fully	fully	RB	RB	_	24	advmod	_	_
24	suppressed	suppress	VBN	VBN	_	7	conj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	CyA	cya	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PILOT	pilot	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	calculated	calculate	VBN	VBN	_	7	amod	_	_
7	M(r)	m(r)	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	42.6	42.6	CD	CD	_	10	nummod	_	_
10	kDa	kda	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	contains	contain	VBZ	VBZ	_	4	conj	_	_
13	three	three	CD	CD	_	15	nummod	_	_
14	zinc	zinc	NN	NN	_	15	compound	_	_
15	fingers	finger	NNS	NNS	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	C2H2-type	c2h2-type	NN	NN	_	15	nmod	_	_
19	at	at	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	carboxyl-terminus	carboxyl-terminus	NN	NN	_	12	nmod	_	_
22	which	which	WDT	WDT	_	25	nsubj	_	_
23	are	be	VBP	VBP	_	25	cop	_	_
24	highly	highly	RB	RB	_	25	advmod	_	_
25	homologous	homologous	JJ	JJ	_	12	dep	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	zinc	zinc	NN	NN	_	30	compound	_	_
29	finger	finger	NN	NN	_	30	compound	_	_
30	regions	region	NNS	NNS	_	25	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	30	nmod	_	_
35	EGR1	egr1	NNS	NNS	_	34	dep	_	_
36	,	,	,	,	_	35	punct	_	_
37	EGR2	egr2	NNS	NNS	_	35	conj	_	_
38	,	,	,	,	_	35	punct	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	pAT	pat	NN	NN	_	35	conj	_	_
41	133	133	CD	CD	_	40	nummod	_	_
42	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	12	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	fibroblasts	fibroblast	NNS	NNS	_	12	nmod	_	_
9	PILOT	pilot	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	12	nsubj	_	_
12	requires	require	VBZ	VBZ	_	0	root	_	_
13	only	only	RB	RB	_	14	advmod	_	_
14	one	one	CD	CD	_	15	nummod	_	_
15	signal	signal	NN	NN	_	12	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	affected	affect	VBN	VBN	_	12	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	CyA	cya	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	4	nsubj	_	_
3	directly	directly	RB	RB	_	4	advmod	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	existence	existence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	Ca2+	ca2+	NN	NN	_	10	nmod:npmod	_	_
10	signal-dependent	signal-dependent	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	6	nmod	_	_
13	obligatory	obligatory	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	expression	expression	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	some	some	DT	DT	_	18	det	_	_
18	genes	gene	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	but	but	CC	CC	_	21	cc	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	in	in	IN	IN	_	25	case	_	_
25	fibroblasts	fibroblast	NNS	NNS	_	21	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	differential	differential	JJ	JJ	_	4	amod	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	model	model	NN	NN	_	7	nsubj	_	_
5	will	will	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	valuable	valuable	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	dissection	dissection	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	dual	dual	JJ	JJ	_	15	amod	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	pathway	pathway	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	effects	effect	NNS	NNS	_	10	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	CyA	cya	NN	NN	_	21	nmod	_	_
24	upon	upon	IN	IN	_	25	case	_	_
25	it	it	PRP	PRP	_	21	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	CD4	cd4	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	5	nsubj	_	_
4	specifically	specifically	RB	RB	_	5	advmod	_	_
5	recognize	recognize	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	peptide	peptide	NN	NN	_	5	dobj	_	_
8	representing	represent	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	hybrid	hybrid	NN	NN	_	17	compound	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	pml/RAR	pml/rar	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	11	nmod	_	_
18	present	present	JJ	JJ	_	17	amod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	acute	acute	JJ	JJ	_	23	amod	_	_
21	promyelocytic	promyelocytic	JJ	JJ	_	23	amod	_	_
22	leukemia	leukemia	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Fusion	fusion	NN	NN	_	2	compound	_	_
2	proteins	protein	NNS	NNS	_	8	nsubj	_	_
3	present	present	JJ	JJ	_	2	amod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	leukemic	leukemic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	frequently	frequently	RB	RB	_	8	advmod	_	_
8	contain	contain	VBP	VBP	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	new	new	JJ	JJ	_	12	amod	_	_
11	amino	amino	NN	NN	_	12	compound	_	_
12	acid	acid	NN	NN	_	8	dobj	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	fusion	fusion	NN	NN	_	16	compound	_	_
16	point	point	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	tested	test	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	35	mark	_	_
4	a	a	DT	DT	_	5	det	_	_
5	peptide	peptide	NN	NN	_	35	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	BCR1/25	bcr1/25	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	encompassing	encompass	VBG	VBG	_	5	acl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	fusion	fusion	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	hybrid	hybrid	NN	NN	_	18	compound	_	_
16	molecule	molecule	NN	NN	_	18	compound	_	_
17	pml/RAR	pml/rar	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	which	which	WDT	WDT	_	23	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	selectively	selectively	RB	RB	_	23	advmod	_	_
23	expressed	express	VBN	VBN	_	5	acl:relcl	_	_
24	by	by	IN	IN	_	31	case	_	_
25	acute	acute	JJ	JJ	_	27	amod	_	_
26	promyelocytic	promyelocytic	JJ	JJ	_	27	amod	_	_
27	leukemia	leukemia	NN	NN	_	31	compound	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	APL	apl	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	cells	cell	NNS	NNS	_	23	nmod	_	_
32	,	,	,	,	_	5	punct	_	_
33	can	can	MD	MD	_	35	aux	_	_
34	be	be	VB	VB	_	35	auxpass	_	_
35	recognized	recognize	VBN	VBN	_	2	ccomp	_	_
36	by	by	IN	IN	_	39	case	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	lymphocytes	lymphocyte	NNS	NNS	_	35	nmod	_	_
40	in	in	FW	FW	_	41	compound	_	_
41	vitro	vitro	FW	FW	_	35	advmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	CD4+	cd4+	JJ	JJ	_	2	amod	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	11	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	at	at	IN	IN	_	9	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	polyclonal	polyclonal	JJ	JJ	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	clonal	clonal	JJ	JJ	_	6	conj	_	_
9	level	level	NN	NN	_	2	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	recognized	recognize	VBD	VBD	_	0	root	_	_
12	peptide	peptide	NN	NN	_	13	compound	_	_
13	BCR1/25	bcr1/25	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	HLA-DR--restricted	hla-dr--restricted	JJ	JJ	_	17	amod	_	_
17	fashion	fashion	NN	NN	_	11	nmod	_	_
18	on	on	IN	IN	_	19	case	_	_
19	presentation	presentation	NN	NN	_	11	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	autologous	autologous	JJ	JJ	_	23	amod	_	_
22	antigen-presenting	antigen-presenting	JJ	JJ	_	23	amod	_	_
23	cell	cell	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	APC	apc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	by	by	IN	IN	_	29	case	_	_
29	APC	apc	NN	NN	_	23	conj	_	_
30	expressing	express	VBG	VBG	_	29	acl	_	_
31	the	the	DT	DT	_	34	det	_	_
32	HLA-DR11	hla-dr11	NN	NN	_	34	compound	_	_
33	restricting	restricting	NN	NN	_	34	compound	_	_
34	molecule	molecule	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	11	punct	_	_

1	Control	control	NN	NN	_	2	compound	_	_
2	peptides	peptide	NNS	NNS	_	14	nsubjpass	_	_
3	corresponding	correspond	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	pml	pml	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	RAR	rar	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	conj	_	_
11	proteins	protein	NNS	NNS	_	3	nmod	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	recognized	recognize	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	clone	clone	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	DEG5	deg5	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	exerted	exert	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	12	det	_	_
9	high	high	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	specific	specific	JJ	JJ	_	9	conj	_	_
12	cytotoxicity	cytotoxicity	NN	NN	_	7	dobj	_	_
13	against	against	IN	IN	_	15	case	_	_
14	autologous	autologous	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	pulsed	pulse	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	BCR1/25	bcr1/25	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	autologous	autologous	JJ	JJ	_	4	amod	_	_
3	DE	de	NN	NN	_	4	compound	_	_
4	LCL	lcl	NN	NN	_	23	nsubj	_	_
5	containing	contain	VBG	VBG	_	4	dep	_	_
6	a	a	DT	DT	_	11	det	_	_
7	transduced	transduce	VBN	VBN	_	11	amod	_	_
8	pml/RAR	pml/rar	NN	NN	_	11	compound	_	_
9	alpha	alpha	NN	NN	_	11	compound	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	5	dobj	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	expressing	express	VBG	VBG	_	5	conj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	bcr1	bcr1	NN	NN	_	16	compound	_	_
16	type	type	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	pml/RAR	pml/rar	NN	NN	_	22	compound	_	_
20	alpha	alpha	NN	NN	_	22	compound	_	_
21	hybrid	hybrid	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	16	nmod	_	_
23	induced	induce	VBD	VBD	_	0	root	_	_
24	the	the	DT	DT	_	25	det	_	_
25	proliferation	proliferation	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	DE	de	NN	NN	_	31	compound	_	_
28	anti-BCR1/25	anti-bcr1/25	CD	CD	_	31	nummod	_	_
29	T	t	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	clones	clone	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	23	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	bcr1	bcr1	NN	NN	_	10	compound	_	_
7	type-pml/RAR	type-pml/rar	NN	NN	_	10	compound	_	_
8	alpha	alpha	NN	NN	_	10	compound	_	_
9	fusion	fusion	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	APL	apl	NN	NN	_	10	nmod	_	_
13	contains	contain	VBZ	VBZ	_	3	ccomp	_	_
14	an	a	DT	DT	_	16	det	_	_
15	antigenic	antigenic	JJ	JJ	_	16	amod	_	_
16	site	site	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	absent	absent	JJ	JJ	_	16	amod	_	_
19	from	from	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	normal	normal	JJ	JJ	_	23	amod	_	_
22	parent	parent	NN	NN	_	23	compound	_	_
23	molecules	molecule	NNS	NNS	_	18	nmod	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	recognized	recognize	VBN	VBN	_	18	conj	_	_
26	by	by	IN	IN	_	29	case	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	CD4+	cd4+	JJ	JJ	_	29	amod	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	serum	serum	NN	NN	_	4	compound	_	_
3	response	response	NN	NN	_	4	compound	_	_
4	element	element	NN	NN	_	11	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	a	a	DT	DT	_	8	det	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	site	site	NN	NN	_	4	conj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	NF-Y	nf-y	NN	NN	_	8	nmod	_	_
11	mediate	mediate	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	serum	serum	NN	NN	_	14	compound	_	_
14	response	response	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	thrombospondin	thrombospondin	NN	NN	_	20	compound	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	gene	gene	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	thrombospondin	thrombospondin	NN	NN	_	2	nmod	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TSP	tsp	NN	NN	_	4	appos	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	)	)	-RRB-	-RRB-	_	7	punct	_	_
10	,	,	,	,	_	4	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	member	member	NN	NN	_	4	appos	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	TSP	tsp	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	family	family	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	rapidly	rapidly	RB	RB	_	21	advmod	_	_
21	induced	induce	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	24	case	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	tested	test	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	TSP	tsp	NN	NN	_	10	compound	_	_
8	1-chloramphenicol	1-chloramphenicol	JJ	JJ	_	10	amod	_	_
9	acetyltransferase	acetyltransferase	NN	NN	_	10	compound	_	_
10	constructs	construct	NNS	NNS	_	4	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	respond	respond	VB	VB	_	4	acl	_	_
13	to	to	TO	TO	_	14	case	_	_
14	serum	serum	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	stably	stably	RB	RB	_	17	advmod	_	_
17	transfected	transfect	VBN	VBN	_	19	amod	_	_
18	NIH-3T3	nih-3t3	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	23	nsubjpass	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	TSP	tsp	NN	NN	_	8	compound	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	distal	distal	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	3	appos	_	_
13	at	at	IN	IN	_	14	case	_	_
14	-1280	-1280	CD	CD	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	proximal	proximal	JJ	JJ	_	18	amod	_	_
18	element	element	NN	NN	_	12	conj	_	_
19	at	at	IN	IN	_	20	case	_	_
20	-65	-65	CD	CD	_	18	nmod	_	_
21	,	,	,	,	_	3	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	required	require	VBN	VBN	_	0	root	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	response	response	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	human	human	JJ	JJ	_	32	amod	_	_
30	TSP	tsp	NN	NN	_	32	compound	_	_
31	1	1	CD	CD	_	32	nummod	_	_
32	gene	gene	NN	NN	_	26	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	serum	serum	NN	NN	_	26	nmod	_	_
35	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	distal	distal	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	5'-CC(A+T)6GG-3'	5'-cc(a+t)6gg-3'	NN	NN	_	8	compound	_	_
7	consensus	consensus	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	4	dobj	_	_
9	characteristic	characteristic	JJ	JJ	_	8	amod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	serum-response	serum-response	JJ	JJ	_	13	amod	_	_
13	element	element	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	SRE	sre	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	4	punct	_	_

1	Deletions	deletion	NNS	NNS	_	7	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	mutations	mutation	NNS	NNS	_	1	conj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	element	element	NN	NN	_	1	nmod	_	_
7	reduced	reduce	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	serum	serum	NN	NN	_	10	compound	_	_
10	response	response	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	TSP	tsp	NN	NN	_	15	compound	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	80-90	80-90	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	gel-shift	gel-shift	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	-1280	-1280	CD	CD	_	7	nummod	_	_
7	element	element	NN	NN	_	12	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	c-fos	c-fos	NN	NN	_	11	compound	_	_
11	SRE	sre	NN	NN	_	7	conj	_	_
12	cross-competed	cross-compete	VBD	VBD	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	whereas	whereas	IN	IN	_	12	dep	_	_
15	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
16	functional	functional	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	binding	bind	VBG	VBG	_	16	conj	_	_
19	mutants	mutant	NNS	NNS	_	20	nsubj	_	_
20	did	do	VBD	VBD	_	12	parataxis	_	_
21	not	not	RB	RB	_	20	neg	_	_
22	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proximal	proximal	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	5'-GGCCAATGGG-3'	5'-ggccaatggg-3'	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	closely	closely	RB	RB	_	11	advmod	_	_
11	resembles	resemble	VBZ	VBZ	_	7	acl:relcl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	consensus	consensus	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	11	xcomp	_	_
16	for	for	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	CCAAT-binding	ccaat-binding	JJ	JJ	_	20	amod	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	NF-Y	nf-y	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CBF	cbf	NN	NN	_	20	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	CP1	cp1	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	22	punct	_	_
26	alpha	alpha	NN	NN	_	27	compound	_	_
27	CP1	cp1	NN	NN	_	22	appos	_	_
28	)	)	-RRB-	-RRB-	_	22	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	Deletions	deletion	NNS	NNS	_	8	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	mutations	mutation	NNS	NNS	_	1	conj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	element	element	NN	NN	_	1	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	reduced	reduce	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	serum	serum	NN	NN	_	11	compound	_	_
11	response	response	NN	NN	_	8	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	80-90	80-90	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Methylation	methylation	NN	NN	_	3	compound	_	_
2	interference	interference	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	-65	-65	CD	CD	_	7	nummod	_	_
7	region	region	NN	NN	_	3	nmod	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	pattern	pattern	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	contacts	contact	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	factors	factor	NNS	NNS	_	12	nmod	_	_
16	resembling	resemble	VBG	VBG	_	10	acl	_	_
17	that	that	DT	DT	_	16	xcomp	_	_
18	for	for	IN	IN	_	19	case	_	_
19	NF-Y	nf-y	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	an	a	DT	DT	_	24	det	_	_
23	NF-Y-binding	nf-y-binding	JJ	JJ	_	24	amod	_	_
24	site	site	NN	NN	_	10	conj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	30	det	_	_
27	proximal	proximal	JJ	JJ	_	30	amod	_	_
28	TSP	tsp	NN	NN	_	30	compound	_	_
29	1	1	CD	CD	_	30	nummod	_	_
30	element	element	NN	NN	_	24	conj	_	_
31	cross-competed	cross-compete	VBD	VBD	_	24	acl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	gel-shift	gel-shift	JJ	JJ	_	34	amod	_	_
34	assays	assay	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	8	punct	_	_
36	whereas	whereas	IN	IN	_	8	dep	_	_
37	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
38	binding	bind	VBG	VBG	_	39	amod	_	_
39	mutants	mutant	NNS	NNS	_	40	nsubj	_	_
40	did	do	VBD	VBD	_	8	parataxis	_	_
41	not	not	RB	RB	_	40	neg	_	_
42	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	an	a	DT	DT	_	7	det	_	_
4	abbreviated	abbreviate	VBN	VBN	_	7	amod	_	_
5	TSP	tsp	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	promoter/5'-flank	promoter/5'-flank	NN	NN	_	16	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	containing	contain	VBG	VBG	_	7	acl	_	_
10	the	the	DT	DT	_	14	det	_	_
11	SRE-	sre-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NF-Y-binding	nf-y-binding	JJ	JJ	_	11	conj	_	_
14	sites	site	NNS	NNS	_	9	dobj	_	_
15	,	,	,	,	_	7	punct	_	_
16	mediated	mediate	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	serum	serum	NN	NN	_	19	compound	_	_
19	response	response	NN	NN	_	16	dobj	_	_
20	that	that	WDT	WDT	_	22	nsubj	_	_
21	was	be	VBD	VBD	_	22	cop	_	_
22	close	close	JJ	JJ	_	19	acl:relcl	_	_
23	in	in	IN	IN	_	24	case	_	_
24	magnitude	magnitude	NN	NN	_	22	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	that	that	DT	DT	_	22	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	parent	parent	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	serum	serum	NN	NN	_	6	compound	_	_
6	response	response	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	TSP	tsp	NN	NN	_	12	compound	_	_
11	1	1	CD	CD	_	12	nummod	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	requires	require	VBZ	VBZ	_	2	ccomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	coordinated	coordinate	VBN	VBN	_	16	amod	_	_
16	function	function	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	an	a	DT	DT	_	22	det	_	_
19	SRE-	sre-	NN	NN	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-Y-binding	nf-y-binding	JJ	JJ	_	19	conj	_	_
22	site	site	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Suppression	suppression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	cellular	cellular	JJ	JJ	_	6	amod	_	_
5	differentiation	differentiation	NN	NN	_	6	compound	_	_
6	program	program	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	phorbol	phorbol	NN	NN	_	9	compound	_	_
9	esters	ester	NNS	NNS	_	1	nmod	_	_
10	coincides	coincide	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	inhibition	inhibition	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	binding	binding	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	NF-E2	nf-e2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	to	to	TO	TO	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	enhancer	enhancer	NN	NN	_	26	compound	_	_
26	element	element	NN	NN	_	14	nmod	_	_
27	required	require	VBN	VBN	_	26	acl	_	_
28	for	for	IN	IN	_	29	case	_	_
29	expression	expression	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	erythroid-specific	erythroid-specific	JJ	JJ	_	33	amod	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	Induction	induction	NN	NN	_	4	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	hemin	hemin	NN	NN	_	1	nmod	_	_
4	increases	increase	VBZ	VBZ	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	while	while	IN	IN	_	13	mark	_	_
7	induction	induction	NN	NN	_	13	nsubj	_	_
8	with	with	IN	IN	_	9	case	_	_
9	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TPA	tpa	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	represses	repress	VBZ	VBZ	_	4	advcl	_	_
14	,	,	,	,	_	4	punct	_	_
15	erythroid-specific	erythroid-specific	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	4	dobj	_	_
18	in	in	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	line	line	NN	NN	_	23	compound	_	_
23	K562	k562	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	hemin	hemin	NN	NN	_	9	compound	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	TPA	tpa	NN	NN	_	6	conj	_	_
9	induction	induction	NN	NN	_	4	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	binding	binding	NN	NN	_	4	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	activity	activity	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	12	nmod	_	_
18	at	at	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	element	element	NN	NN	_	12	nmod	_	_
22	found	find	VBN	VBN	_	21	acl	_	_
23	within	within	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	regulatory	regulatory	JJ	JJ	_	27	amod	_	_
27	sequences	sequence	NNS	NNS	_	22	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	many	many	JJ	JJ	_	31	amod	_	_
30	erythroid-specific	erythroid-specific	JJ	JJ	_	31	amod	_	_
31	genes	gene	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	TPA	tpa	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	3	nsubj	_	_
3	increases	increase	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	ubiquitous	ubiquitous	JJ	JJ	_	9	amod	_	_
8	AP-1	ap-1	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	element	element	NN	NN	_	5	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	TPA	tpa	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	lineage	lineage	NN	NN	_	9	nmod:npmod	_	_
9	limited	limited	JJ	JJ	_	12	amod	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	NF-E2	nf-e2	NN	NN	_	5	nmod	_	_
13	to	to	TO	TO	_	17	case	_	_
14	this	this	DT	DT	_	17	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
16	control	control	NN	NN	_	17	compound	_	_
17	element	element	NN	NN	_	5	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Hemin	hemin	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	K562	k562	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	does	do	VBZ	VBZ	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	facilitate	facilitate	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	binding	binding	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-E2	nf-e2	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	recognition	recognition	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Hemin	hemin	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	nonspecifically	nonspecifically	RB	RB	_	6	advmod	_	_
6	increase	increase	VB	VB	_	3	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	transiently	transiently	RB	RB	_	11	advmod	_	_
11	transfected	transfect	VBN	VBN	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	K562	k562	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Beyond	beyond	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	nonspecific	nonspecific	JJ	JJ	_	4	amod	_	_
4	increase	increase	NN	NN	_	11	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	hemin	hemin	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	11	nsubj	_	_
11	acts	act	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	increase	increase	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	lineage	lineage	NN	NN	_	19	nmod:npmod	_	_
19	limited	limited	JJ	JJ	_	22	amod	_	_
20	transcription	transcription	NN	NN	_	22	compound	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	NF-E2	nf-e2	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	divergent	divergent	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	hemin	hemin	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	TPA	tpa	NN	NN	_	5	conj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	3	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	K562	k562	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	23	punct	_	_
17	in	in	IN	IN	_	18	case	_	_
18	part	part	NN	NN	_	23	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	by	by	IN	IN	_	23	case	_	_
21	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
22	contrasting	contrasting	JJ	JJ	_	23	amod	_	_
23	effects	effect	NNS	NNS	_	15	nmod	_	_
24	on	on	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	NF-E2	nf-e2	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	interleukin	interleukin	NN	NN	_	5	compound	_	_
3	2	2	CD	CD	_	5	nummod	_	_
4	CD28-responsive	cd28-responsive	JJ	JJ	_	5	amod	_	_
5	complex	complex	NN	NN	_	6	nsubj	_	_
6	contains	contain	VBZ	VBZ	_	0	root	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	three	three	CD	CD	_	10	nummod	_	_
10	members	member	NNS	NNS	_	6	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	NF	nf	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	family	family	NN	NN	_	10	nmod	_	_
17	:	:	:	:	_	10	punct	_	_
18	c-Rel	c-rel	NN	NN	_	10	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	p50	p50	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	p65	p65	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	6	punct	_	_

1	Optimal	optimal	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	signals	signal	NNS	NNS	_	6	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	signal	signal	NN	NN	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	delivered	deliver	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	antigen-specific	antigen-specific	JJ	JJ	_	10	amod	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	second	second	JJ	JJ	_	15	amod	_	_
15	signal	signal	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	provided	provide	VBN	VBN	_	5	conj	_	_
18	by	by	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	costimulatory	costimulatory	JJ	JJ	_	23	amod	_	_
21	molecule	molecule	NN	NN	_	23	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	s	s	NNS	NNS	_	17	nmod	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	delivered	deliver	VBN	VBN	_	23	acl	_	_
26	by	by	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	antigen-presenting	antigen-presenting	JJ	JJ	_	29	amod	_	_
29	cell	cell	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	CD28	cd28	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	T-cell	t-cell	NN	NN	_	6	compound	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	molecule	molecule	NN	NN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	stimulation	stimulation	NN	NN	_	12	nsubj	_	_
9	through	through	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	8	nmod	_	_
12	plays	play	VBZ	VBZ	_	6	conj	_	_
13	an	a	DT	DT	_	15	det	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	delivering	deliver	VBG	VBG	_	12	advcl	_	_
18	the	the	DT	DT	_	21	det	_	_
19	second	second	JJ	JJ	_	21	amod	_	_
20	activation	activation	NN	NN	_	21	compound	_	_
21	signal	signal	NN	NN	_	17	dobj	_	_
22	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	in	in	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	18	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	CD28-mediated	cd28-mediated	JJ	JJ	_	17	amod	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	18	nsubj	_	_
18	involves	involve	VBZ	VBZ	_	6	ccomp	_	_
19	the	the	DT	DT	_	22	det	_	_
20	rel	rel	NN	NN	_	22	compound	_	_
21	family	family	NN	NN	_	22	compound	_	_
22	proteins	protein	NNS	NNS	_	18	dobj	_	_
23	--	--	:	:	_	22	punct	_	_
24	c-Rel	c-rel	NN	NN	_	22	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	p50	p50	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	p65	p65	NN	NN	_	24	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Treatment	treatment	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
4	blood	blood	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	12-myristate	12-myristate	NN	NN	_	10	compound	_	_
10	13-acetate	13-acetate	NN	NN	_	1	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMA	pma	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	anti-CD28	anti-cd28	JJ	JJ	_	17	amod	_	_
16	monoclonal	monoclonal	JJ	JJ	_	17	amod	_	_
17	antibody	antibody	NN	NN	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	mAb	mab	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	results	result	VBZ	VBZ	_	0	root	_	_
22	in	in	IN	IN	_	23	case	_	_
23	augmentation	augmentation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	c-Rel	c-rel	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	p50	p50	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	p65	p65	NN	NN	_	26	conj	_	_
32	,	,	,	,	_	21	punct	_	_
33	and	and	CC	CC	_	21	cc	_	_
34	this	this	DT	DT	_	35	det	_	_
35	augmentation	augmentation	NN	NN	_	37	nsubj	_	_
36	can	can	MD	MD	_	37	aux	_	_
37	occur	occur	VB	VB	_	21	conj	_	_
38	in	in	IN	IN	_	45	case	_	_
39	the	the	DT	DT	_	45	dep	_	_
40	presence	presence	NN	NN	_	45	dep	_	_
41	of	of	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	immunosuppressant	immunosuppressant	JJ	JJ	_	45	amod	_	_
44	cyclosporin	cyclosporin	NN	NN	_	45	compound	_	_
45	A	a	NN	NN	_	37	nmod	_	_
46	.	.	.	.	_	21	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	report	report	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	26	mark	_	_
9	,	,	,	,	_	26	punct	_	_
10	in	in	IN	IN	_	14	case	_	_
11	response	response	NN	NN	_	14	dep	_	_
12	to	to	TO	TO	_	14	case	_	_
13	PMA/anti-CD28	pma/anti-cd28	JJ	JJ	_	14	amod	_	_
14	mAb	mab	NN	NN	_	26	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	anti-CD3/anti-CD28	anti-cd3/anti-cd28	JJ	JJ	_	17	amod	_	_
17	mAb	mab	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	26	punct	_	_
19	c-Rel	c-rel	NN	NN	_	26	nsubjpass	_	_
20	,	,	,	,	_	19	punct	_	_
21	p50	p50	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	p65	p65	NN	NN	_	19	conj	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	associated	associate	VBN	VBN	_	4	ccomp	_	_
27	with	with	IN	IN	_	29	case	_	_
28	CD28-responsive	cd28-responsive	JJ	JJ	_	29	amod	_	_
29	element	element	NN	NN	_	26	nmod	_	_
30	present	present	JJ	JJ	_	29	amod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	promoter	promoter	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	human	human	JJ	JJ	_	39	amod	_	_
37	interleukin	interleukin	NN	NN	_	39	compound	_	_
38	2	2	CD	CD	_	39	nummod	_	_
39	gene	gene	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	significance	significance	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	c-Rel	c-rel	NN	NN	_	6	compound	_	_
6	involvement	involvement	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD28-responsive	cd28-responsive	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	transient	transient	JJ	JJ	_	16	amod	_	_
15	transfection	transfection	NN	NN	_	16	compound	_	_
16	analysis	analysis	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	where	where	WRB	WRB	_	22	advmod	_	_
19	cotransfection	cotransfection	NN	NN	_	22	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	c-Rel	c-rel	NN	NN	_	19	nmod	_	_
22	augments	augment	VBZ	VBZ	_	16	acl:relcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	level	level	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	expression	expression	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	chloramphenicol	chloramphenicol	JJ	JJ	_	32	amod	_	_
30	acetyltransferase	acetyltransferase	NN	NN	_	32	compound	_	_
31	reporter	reporter	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	26	nmod	_	_
33	linked	link	VBN	VBN	_	32	acl	_	_
34	to	to	TO	TO	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	CD28-responsive	cd28-responsive	JJ	JJ	_	37	amod	_	_
37	element	element	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	12	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Tat	tat	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HIV1	hiv1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	promonocytic	promonocytic	JJ	JJ	_	12	amod	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Numerous	numerous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	,	,	,	,	_	16	punct	_	_
7	upon	upon	IN	IN	_	9	case	_	_
8	HIV1	hiv1	NN	NN	_	9	compound	_	_
9	infection	infection	NN	NN	_	16	nmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	promonocytic	promonocytic	JJ	JJ	_	14	amod	_	_
13	U937	u937	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	4	ccomp	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	differentiate	differentiate	VB	VB	_	16	xcomp	_	_
19	,	,	,	,	_	18	punct	_	_
20	as	as	IN	IN	_	21	mark	_	_
21	indicated	indicate	VBN	VBN	_	18	advcl	_	_
22	,	,	,	,	_	21	punct	_	_
23	for	for	IN	IN	_	24	case	_	_
24	example	example	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	by	by	IN	IN	_	28	case	_	_
27	increased	increase	VBN	VBN	_	28	amod	_	_
28	expression	expression	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	adhesion	adhesion	NN	NN	_	31	compound	_	_
31	molecules	molecule	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	viral	viral	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	1	nmod	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	process	process	NN	NN	_	6	nmod	_	_
10	might	might	MD	MD	_	14	aux	_	_
11	be	be	VB	VB	_	14	cop	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Tat	tat	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Indeed	indeed	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	viral	viral	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	17	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	5	acl:relcl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	productive	productive	JJ	JJ	_	12	amod	_	_
12	infection	infection	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	has	have	VBZ	VBZ	_	17	aux	_	_
15	also	also	RB	RB	_	17	advmod	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	shown	show	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	display	display	VB	VB	_	17	xcomp	_	_
20	growth-stimulating	growth-stimulating	JJ	JJ	_	21	amod	_	_
21	properties	property	NNS	NNS	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	immunomodulatory	immunomodulatory	JJ	JJ	_	24	amod	_	_
24	activities	activity	NNS	NNS	_	21	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	apprehend	apprehend	VB	VB	_	24	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	HIV1	hiv1	NN	NN	_	11	compound	_	_
10	tat	tat	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	inducing	induce	VBG	VBG	_	6	acl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	differentiation	differentiation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	HIV1-infected	hiv1-infected	JJ	JJ	_	19	amod	_	_
18	U937	u937	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	24	punct	_	_
21	we	we	PRP	PRP	_	24	nsubj	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	successfully	successfully	RB	RB	_	24	advmod	_	_
24	introduced	introduce	VBN	VBN	_	0	root	_	_
25	this	this	DT	DT	_	26	det	_	_
26	gene	gene	NN	NN	_	24	dobj	_	_
27	into	into	IN	IN	_	29	case	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	by	by	IN	IN	_	31	mark	_	_
31	infecting	infect	VBG	VBG	_	24	advcl	_	_
32	them	they	PRP	PRP	_	31	dobj	_	_
33	with	with	IN	IN	_	37	case	_	_
34	retroviral	retroviral	JJ	JJ	_	37	amod	_	_
35	particles	particle	NNS	NNS	_	37	compound	_	_
36	transducing	transduce	VBG	VBG	_	37	amod	_	_
37	tat	tat	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Tat	tat	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	6	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	differentiation	differentiation	NN	NN	_	8	nmod	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	then	then	RB	RB	_	17	advmod	_	_
17	evaluated	evaluate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	looking	look	VBG	VBG	_	17	advcl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	c-fos	c-fos	NN	NN	_	30	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	c-fms	c-fms	NN	NN	_	25	conj	_	_
30	proto-oncogenes	proto-oncogene	NNS	NNS	_	22	nmod	_	_
31	which	which	WDT	WDT	_	33	nsubjpass	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	linked	link	VBN	VBN	_	30	dep	_	_
34	to	to	TO	TO	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	differentiation	differentiation	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	myelomonoblastic	myelomonoblastic	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	17	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	4	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	transcription	transcription	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	these	these	DT	DT	_	17	det	_	_
16	two	two	CD	CD	_	17	nummod	_	_
17	proto-oncogenes	proto-oncogene	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	this	this	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	amplified	amplify	VBN	VBN	_	4	conj	_	_
24	after	after	IN	IN	_	25	case	_	_
25	treatment	treatment	NN	NN	_	23	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	myristate	myristate	NN	NN	_	29	compound	_	_
29	acetate	acetate	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	such	such	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	control	control	NN	NN	_	9	compound	_	_
8	U937	u937	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	,	,	,	,	_	14	punct	_	_
6	among	among	IN	IN	_	9	case	_	_
7	HIV1	hiv1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	products	product	NNS	NNS	_	14	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Tat	tat	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	14	nsubj	_	_
14	appears	appear	VBZ	VBZ	_	3	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	trigger	trigger	VB	VB	_	14	xcomp	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	3	punct	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	suggests	suggest	VBZ	VBZ	_	3	conj	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	this	this	DT	DT	_	25	det	_	_
24	viral	viral	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	26	nsubj	_	_
26	directs	direct	VBZ	VBZ	_	21	ccomp	_	_
27	progenitors	progenitor	NNS	NNS	_	26	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	monocyte/macrophage	monocyte/macrophage	NN	NN	_	31	compound	_	_
31	lineage	lineage	NN	NN	_	27	nmod	_	_
32	towards	towards	IN	IN	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	differentiation	differentiation	NN	NN	_	35	compound	_	_
35	stage	stage	NN	NN	_	26	nmod	_	_
36	in	in	IN	IN	_	37	case	_	_
37	which	which	WDT	WDT	_	47	nmod	_	_
38	production	production	NN	NN	_	47	nsubj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	viral	viral	JJ	JJ	_	41	amod	_	_
41	antigens	antigen	NNS	NNS	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	virions	virion	NNS	NNS	_	41	conj	_	_
44	might	might	MD	MD	_	47	aux	_	_
45	be	be	VB	VB	_	47	cop	_	_
46	more	more	RBR	RBR	_	47	advmod	_	_
47	efficient	efficient	JJ	JJ	_	35	acl:relcl	_	_
48	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	pyruvate	pyruvate	NN	NN	_	8	compound	_	_
6	kinase	kinase	NN	NN	_	8	compound	_	_
7	erythroid-specific	erythroid-specific	JJ	JJ	_	8	amod	_	_
8	promoter	promoter	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Mammal	mammal	JJ	JJ	_	3	amod	_	_
2	pyruvate	pyruvate	NN	NN	_	3	compound	_	_
3	kinases	kinase	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	encoded	encode	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	L	l	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	produces	produce	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	erythroid	erythroid	JJ	JJ	_	4	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	R-PK	r-pk	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	or	or	CC	CC	_	6	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	hepatic	hepatic	JJ	JJ	_	6	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	L-PK	l-pk	JJ	JJ	_	12	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	isozymes	isozyme	NNS	NNS	_	6	dep	_	_
17	by	by	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	alternative	alternative	JJ	JJ	_	20	amod	_	_
20	use	use	NN	NN	_	4	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	two	two	CD	CD	_	23	nummod	_	_
23	promoters	promoter	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	characterization	characterization	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	cis-	cis-	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	trans-acting	trans-acting	JJ	JJ	_	7	conj	_	_
10	elements	element	NNS	NNS	_	4	nmod	_	_
11	involved	involve	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	tissue-specific	tissue-specific	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	L	l	NN	NN	_	21	compound	_	_
19	gene	gene	NN	NN	_	21	compound	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	promoter	promoter	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	R-PK	r-pk	NN	NN	_	4	compound	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	fragment	fragment	NN	NN	_	15	nsubj	_	_
5	extending	extend	VBG	VBG	_	4	acl	_	_
6	from	from	IN	IN	_	7	case	_	_
7	-870	-870	CD	CD	_	5	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	+54	+54	CD	CD	_	7	nmod	_	_
10	relative	relative	JJ	JJ	_	14	case	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cap	cap	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	5	nmod	_	_
15	confers	confer	VBZ	VBZ	_	0	root	_	_
16	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
17	specificity	specificity	NN	NN	_	15	dobj	_	_
18	to	to	TO	TO	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	reporter	reporter	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	define	define	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	minimal	minimal	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	6	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	-62	-62	CD	CD	_	9	dep	_	_
12	to	to	TO	TO	_	11	dep	_	_
13	+54	+54	CD	CD	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	displays	display	VBZ	VBZ	_	9	acl:relcl	_	_
17	erythroid-specific	erythroid-specific	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	contains	contain	VBZ	VBZ	_	16	conj	_	_
21	two	two	CD	CD	_	24	nummod	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	sites	site	NNS	NNS	_	20	dobj	_	_
25	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	located	located	JJ	JJ	_	1	amod	_	_
4	at	at	IN	IN	_	5	case	_	_
5	-50	-50	CD	CD	_	3	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	binds	bind	VBZ	VBZ	_	0	root	_	_
8	members	member	NNS	NNS	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CCACC/Sp1	ccacc/sp1	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	other	other	JJ	JJ	_	21	nsubj	_	_
16	,	,	,	,	_	15	punct	_	_
17	located	located	JJ	JJ	_	15	amod	_	_
18	at	at	IN	IN	_	19	case	_	_
19	-20	-20	CD	CD	_	17	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	binds	bind	VBZ	VBZ	_	7	conj	_	_
22	the	the	DT	DT	_	25	det	_	_
23	erythroid	erythroid	JJ	JJ	_	25	amod	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	GATA-1	gata-1	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	16	mark	_	_
2	the	the	DT	DT	_	6	det	_	_
3	-20	-20	CD	CD	_	6	nummod	_	_
4	GATA	gata	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	AGATAA	agataa	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	16	cop	_	_
11	also	also	RB	RB	_	16	advmod	_	_
12	a	a	DT	DT	_	16	det	_	_
13	potential	potential	JJ	JJ	_	16	amod	_	_
14	TFIID	tfiid	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	21	advcl	_	_
17	,	,	,	,	_	21	punct	_	_
18	it	it	PRP	PRP	_	21	nsubj	_	_
19	does	do	VBZ	VBZ	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	bind	bind	VB	VB	_	0	root	_	_
22	TFIID	tfiid	NN	NN	_	21	dobj	_	_
23	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	substitution	substitution	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	this	this	DT	DT	_	9	det	_	_
7	GATA	gata	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	4	nmod	_	_
10	by	by	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	canonical	canonical	JJ	JJ	_	15	amod	_	_
13	TFIID	tfiid	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	4	nmod	_	_
16	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
17	the	the	DT	DT	_	19	det	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	Mutations	mutation	NNS	NNS	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	deletions	deletion	NNS	NNS	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	both	both	DT	DT	_	6	det	_	_
6	sites	site	NNS	NNS	_	1	nmod	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	only	only	RB	RB	_	11	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	association	association	NN	NN	_	19	nsubj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	CCACC/Sp1	ccacc/sp1	NN	NN	_	17	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	GATA	gata	NN	NN	_	13	conj	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	sites	site	NNS	NNS	_	11	nmod	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	drive	drive	VB	VB	_	7	ccomp	_	_
20	efficient	efficient	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	tissue-specific	tissue-specific	JJ	JJ	_	20	conj	_	_
23	expression	expression	NN	NN	_	19	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	this	this	DT	DT	_	28	det	_	_
26	R-PK	r-pk	NN	NN	_	28	compound	_	_
27	minimal	minimal	JJ	JJ	_	28	amod	_	_
28	promoter	promoter	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	by	by	IN	IN	_	5	case	_	_
4	co-transfection	co-transfection	NN	NN	_	5	compound	_	_
5	experiments	experiment	NNS	NNS	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	study	study	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	elements	element	NNS	NNS	_	8	dobj	_	_
11	involved	involve	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	hGATA-1	hgata-1	NN	NN	_	15	compound	_	_
15	transactivation	transactivation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	R-PK	r-pk	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	HeLa	hela	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	interleukin-1	interleukin-1	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	interleukin-1	interleukin-1	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	4	conj	_	_
8	production	production	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	18	case	_	_
13	protein	protein	NN	NN	_	18	compound	_	_
14	phosphatase	phosphatase	NN	NN	_	18	compound	_	_
15	1	1	CD	CD	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	2A	2a	NN	NN	_	15	conj	_	_
18	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Protein	protein	NN	NN	_	2	compound	_	_
2	phosphatases	phosphatase	NNS	NNS	_	7	nsubj	_	_
3	1	1	CD	CD	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	2A	2a	NN	NN	_	3	conj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	important	important	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	regulating	regulate	VBG	VBG	_	7	advcl	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	functions	function	NNS	NNS	_	9	dobj	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	controlling	control	VBG	VBG	_	9	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	phosphorylation	phosphorylation	NN	NN	_	16	compound	_	_
16	state	state	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	substrates	substrate	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
4	,	,	,	,	_	18	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inhibitors	inhibitor	NNS	NNS	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	phosphatases	phosphatase	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	okadaic	okadaic	JJ	JJ	_	12	amod	_	_
12	acid	acid	NN	NN	_	6	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	calyculin	calyculin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	6	punct	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	increase	increase	VB	VB	_	18	xcomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	mRNA	mrna	NN	NN	_	23	compound	_	_
23	accumulation	accumulation	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	cytokine	cytokine	NN	NN	_	26	compound	_	_
26	production	production	NN	NN	_	23	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	interleukin-1	interleukin-1	NN	NN	_	29	compound	_	_
29	beta	beta	NN	NN	_	23	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	interleukin-1	interleukin-1	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	increased	increase	VBN	VBN	_	4	amod	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	accumulation	accumulation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	13	mark	_	_
8	be	be	VB	VB	_	13	cop	_	_
9	primarily	primarily	RB	RB	_	13	advmod	_	_
10	because	because	IN	IN	_	13	case	_	_
11	of	of	IN	IN	_	10	mwe	_	_
12	the	the	DT	DT	_	13	det	_	_
13	increase	increase	NN	NN	_	6	xcomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	rate	rate	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	interleukin-1	interleukin-1	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Stimulation	stimulation	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	interleukin-1	interleukin-1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	1	nmod	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	caused	cause	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	stimulation	stimulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	activities	activity	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	including	include	VBG	VBG	_	18	case	_	_
18	those	those	DT	DT	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	AP-1	ap-1	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	by	by	IN	IN	_	26	case	_	_
23	these	these	DT	DT	_	26	det	_	_
24	protein	protein	NN	NN	_	26	compound	_	_
25	phosphatase	phosphatase	NN	NN	_	26	compound	_	_
26	inhibitors	inhibitor	NNS	NNS	_	11	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	synthesis	synthesis	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	interleukin-1	interleukin-1	NN	NN	_	13	compound	_	_
9	beta	beta	NN	NN	_	13	compound	_	_
10	precursor	precursor	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	mature	mature	JJ	JJ	_	10	conj	_	_
13	forms	form	NNS	NNS	_	5	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	secretion	secretion	NN	NN	_	5	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	increased	increase	VBD	VBD	_	3	amod	_	_
3	processing	processing	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	secretion	secretion	NN	NN	_	3	conj	_	_
6	correlated	correlate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	stimulation	stimulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	IL-1	il-1	NN	NN	_	15	compound	_	_
12	beta	beta	NN	NN	_	15	compound	_	_
13	convertase	convertase	NN	NN	_	15	compound	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	accumulation	accumulation	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	stimulation	stimulation	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	interleukin-1	interleukin-1	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	okadaic	okadaic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	modest	modest	JJ	JJ	_	0	root	_	_
13	than	than	IN	IN	_	14	case	_	_
14	that	that	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	interleukin-1	interleukin-1	NN	NN	_	17	compound	_	_
17	beta	beta	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	phosphorylation	phosphorylation	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	precursor	precursor	NN	NN	_	10	compound	_	_
8	interleukin-1	interleukin-1	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	cytokine	cytokine	NN	NN	_	4	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	increased	increase	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	protein	protein	NN	NN	_	10	compound	_	_
6	phosphatase	phosphatase	NN	NN	_	10	compound	_	_
7	1	1	CD	CD	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	2A	2a	NN	NN	_	7	conj	_	_
10	inhibitors	inhibitor	NNS	NNS	_	11	nsubj	_	_
11	exert	exert	VBP	VBP	_	3	ccomp	_	_
12	multiple	multiple	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	suggest	suggest	VBP	VBP	_	3	conj	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	these	these	DT	DT	_	25	det	_	_
24	two	two	CD	CD	_	25	nummod	_	_
25	phosphatases	phosphatase	NNS	NNS	_	26	nsubj	_	_
26	play	play	VBP	VBP	_	21	ccomp	_	_
27	important	important	JJ	JJ	_	28	amod	_	_
28	roles	role	NNS	NNS	_	26	dobj	_	_
29	in	in	IN	IN	_	30	mark	_	_
30	regulating	regulate	VBG	VBG	_	26	advcl	_	_
31	interleukin-1	interleukin-1	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	3	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	type-	type-	NN	NN	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	stage-specific	stage-specific	JJ	JJ	_	2	conj	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CD20/B1	cd20/b1	NN	NN	_	9	compound	_	_
9	antigen	antigen	NN	NN	_	5	nmod	_	_
10	correlates	correlate	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	diverged	diverged	JJ	JJ	_	19	amod	_	_
17	octamer	octamer	NN	NN	_	19	compound	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	motif	motif	NN	NN	_	13	nmod	_	_
20	present	present	JJ	JJ	_	19	amod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	promoter	promoter	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	CD20	cd20	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	B1	b1	NN	NN	_	6	compound	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	gene	gene	NN	NN	_	7	nsubj	_	_
7	encodes	encode	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	B	b	NN	NN	_	10	nmod:npmod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	dobj	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	regulation	regulation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	15	nmod	_	_
20	proliferation	proliferation	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	differentiation	differentiation	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	Studies	study	NNS	NNS	_	10	nsubj	_	_
2	with	with	IN	IN	_	7	case	_	_
3	5'	5'	JJ	JJ	_	7	amod	_	_
4	deletion	deletion	NN	NN	_	7	compound	_	_
5	CD20	cd20	NN	NN	_	7	compound	_	_
6	promoter-CAT	promoter-cat	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	1	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	revealed	reveal	VBN	VBN	_	0	root	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	regions	region	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	promoter	promoter	NN	NN	_	12	nmod	_	_
16	between	between	IN	IN	_	17	case	_	_
17	bases	basis	NNS	NNS	_	12	nmod	_	_
18	-186	-186	CD	CD	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-280	-280	CD	CD	_	18	conj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	between	between	IN	IN	_	23	case	_	_
23	bases	basis	NNS	NNS	_	17	conj	_	_
24	-280	-280	CD	CD	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	-454	-454	CD	CD	_	24	conj	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	contained	contain	VBD	VBD	_	12	acl:relcl	_	_
29	positive	positive	JJ	JJ	_	31	amod	_	_
30	regulatory	regulatory	JJ	JJ	_	31	amod	_	_
31	elements	element	NNS	NNS	_	28	dobj	_	_
32	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	5	dobj	_	_
9	present	present	JJ	JJ	_	8	amod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	most	most	RBS	RBS	_	13	advmod	_	_
13	proximal	proximal	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	9	nmod	_	_
15	located	located	JJ	JJ	_	14	amod	_	_
16	between	between	IN	IN	_	17	case	_	_
17	bases	basis	NNS	NNS	_	15	nmod	_	_
18	-214	-214	CD	CD	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-201	-201	CD	CD	_	18	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	TTCTTCTAATTAA	ttcttctaattaa	NN	NN	_	14	appos	_	_
23	,	,	,	,	_	8	punct	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	important	important	JJ	JJ	_	8	acl:relcl	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	high	high	JJ	JJ	_	31	amod	_	_
30	constitutive	constitutive	JJ	JJ	_	31	amod	_	_
31	expression	expression	NN	NN	_	26	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	CD20	cd20	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	mature	mature	JJ	JJ	_	37	amod	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	31	nmod	_	_
38	and	and	CC	CC	_	31	cc	_	_
39	the	the	DT	DT	_	40	det	_	_
40	induction	induction	NN	NN	_	31	conj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	CD20	cd20	NN	NN	_	40	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	pre-B	pre-b	JJ	JJ	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	40	nmod	_	_
46	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	referred	refer	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	5	nmod	_	_
7	as	as	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	BAT	bat	NN	NN	_	10	compound	_	_
10	box	box	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	deletion	deletion	NN	NN	_	15	nsubj	_	_
14	significantly	significantly	RB	RB	_	15	advmod	_	_
15	reduced	reduce	VBD	VBD	_	5	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activity	activity	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	CD20	cd20	NN	NN	_	22	compound	_	_
21	promoter-CAT	promoter-cat	JJ	JJ	_	22	amod	_	_
22	construct	construct	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Mobility	mobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	13	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	various	various	JJ	JJ	_	7	amod	_	_
6	mutant	mutant	JJ	JJ	_	7	amod	_	_
7	probes	probe	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	B	b	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	extracts	extract	NNS	NNS	_	7	conj	_	_
13	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	core	core	NN	NN	_	18	compound	_	_
17	sequence	sequence	NN	NN	_	18	compound	_	_
18	TAAT	taat	NN	NN	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	essential	essential	JJ	JJ	_	13	ccomp	_	_
21	for	for	IN	IN	_	22	mark	_	_
22	binding	bind	VBG	VBG	_	20	advcl	_	_
23	to	to	TO	TO	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	site	site	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Cross	cross	NN	NN	_	3	compound	_	_
2	competition	competition	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	28	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	octamer	octamer	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	3	nmod	_	_
8	from	from	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	Ig	ig	NN	NN	_	13	compound	_	_
11	heavy	heavy	JJ	JJ	_	13	amod	_	_
12	chain	chain	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	the	the	DT	DT	_	17	det	_	_
16	BAT	bat	NN	NN	_	17	compound	_	_
17	box	box	NN	NN	_	7	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	TA-rich	ta-rich	JJ	JJ	_	22	amod	_	_
22	sequence	sequence	NN	NN	_	7	conj	_	_
23	present	present	JJ	JJ	_	22	amod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	CD21	cd21	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	23	nmod	_	_
28	revealed	reveal	VBD	VBD	_	0	root	_	_
29	that	that	IN	IN	_	33	mark	_	_
30	all	all	DT	DT	_	32	det	_	_
31	three	three	CD	CD	_	32	nummod	_	_
32	sequences	sequence	NNS	NNS	_	33	nsubj	_	_
33	bound	bind	VBD	VBD	_	28	ccomp	_	_
34	the	the	DT	DT	_	37	det	_	_
35	same	same	JJ	JJ	_	37	amod	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	proteins	protein	NNS	NNS	_	33	dobj	_	_
38	suggesting	suggest	VBG	VBG	_	33	xcomp	_	_
39	that	that	IN	IN	_	46	mark	_	_
40	the	the	DT	DT	_	44	det	_	_
41	BAT	bat	NN	NN	_	44	compound	_	_
42	box	box	NN	NN	_	44	compound	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	proteins	protein	NNS	NNS	_	46	nsubj	_	_
45	were	be	VBD	VBD	_	46	cop	_	_
46	Oct-1	oct-1	NN	NN	_	38	ccomp	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	Oct-2	oct-2	NN	NN	_	46	conj	_	_
49	.	.	.	.	_	28	punct	_	_

1	Southwestern	southwestern	NN	NN	_	2	compound	_	_
2	blotting	blotting	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	UV	uv	NN	NN	_	6	compound	_	_
5	cross-linking	cross-linking	NN	NN	_	6	compound	_	_
6	studies	study	NNS	NNS	_	2	conj	_	_
7	confirmed	confirm	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	the	the	DT	DT	_	13	det	_	_
10	BAT	bat	NN	NN	_	13	compound	_	_
11	box	box	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	15	nsubj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	Oct-1	oct-1	NN	NN	_	7	ccomp	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Oct-2	oct-2	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	affinity	affinity	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	BAT	bat	NN	NN	_	8	compound	_	_
6	box	box	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	2	nmod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	BAT	bat	NN	NN	_	12	compound	_	_
12	box	box	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	16	cop	_	_
14	approximately	approximately	RB	RB	_	15	advmod	_	_
15	25-fold	25-fold	RB	RB	_	16	advmod	_	_
16	less	less	JJR	JJR	_	0	root	_	_
17	than	than	IN	IN	_	21	case	_	_
18	for	for	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	octamer	octamer	NN	NN	_	21	compound	_	_
21	sequence	sequence	NN	NN	_	16	advcl	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	the	the	DT	DT	_	27	det	_	_
24	BAT	bat	NN	NN	_	27	compound	_	_
25	box	box	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	28	nsubj	_	_
28	dissociated	dissociate	VBD	VBD	_	16	conj	_	_
29	from	from	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	BAT	bat	NN	NN	_	32	compound	_	_
32	box	box	NN	NN	_	28	nmod	_	_
33	10-fold	10-fold	RB	RB	_	34	advmod	_	_
34	more	more	RBR	RBR	_	35	advmod	_	_
35	rapidly	rapidly	RB	RB	_	28	advmod	_	_
36	than	than	IN	IN	_	40	case	_	_
37	from	from	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	octamer	octamer	NN	NN	_	40	compound	_	_
40	sequence	sequence	NN	NN	_	35	advcl	_	_
41	.	.	.	.	_	16	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	lower	lower	JJR	JJR	_	4	amod	_	_
4	affinity	affinity	NN	NN	_	16	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	trimer	trimer	NN	NN	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	BAT	bat	NN	NN	_	12	compound	_	_
11	box	box	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	16	auxpass	_	_
14	as	as	IN	IN	_	15	case	_	_
15	efficiently	efficiently	RB	RB	_	16	advmod	_	_
16	transactivated	transactivate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	21	case	_	_
18	an	a	DT	DT	_	21	det	_	_
19	Oct-2	oct-2	NN	NN	_	21	compound	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	vector	vector	NN	NN	_	16	nmod	_	_
22	as	as	IN	IN	_	25	dep	_	_
23	was	be	VBD	VBD	_	25	dep	_	_
24	a	a	DT	DT	_	25	det	_	_
25	trimer	trimer	NN	NN	_	16	advcl	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	octamer	octamer	NN	NN	_	29	compound	_	_
29	sequence	sequence	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	HeLa	hela	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	BAT	bat	NN	NN	_	3	compound	_	_
3	box	box	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Oct-2	oct-2	NN	NN	_	3	conj	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	implicated	implicate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CD20	cd20	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	pre-B	pre-b	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	11	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	PB-697	pb-697	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	8	punct	_	_
22	via	via	IN	IN	_	24	case	_	_
23	phorbol	phorbol	NN	NN	_	24	compound	_	_
24	esters	ester	NNS	NNS	_	8	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CD20	cd20	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	temporally	temporally	RB	RB	_	8	advmod	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	induction	induction	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Oct-2	oct-2	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	a	a	DT	DT	_	19	det	_	_
16	BAT	bat	NN	NN	_	17	nmod:npmod	_	_
17	box-deleted	box-deleted	JJ	JJ	_	19	amod	_	_
18	CD20-CAT	cd20-cat	NN	NN	_	19	compound	_	_
19	construct	construct	NN	NN	_	30	nsubjpass	_	_
20	,	,	,	,	_	30	punct	_	_
21	in	in	IN	IN	_	26	case	_	_
22	contrast	contrast	NN	NN	_	26	dep	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	wild	wild	JJ	JJ	_	26	amod	_	_
26	type	type	NN	NN	_	30	nmod	_	_
27	,	,	,	,	_	30	punct	_	_
28	was	be	VBD	VBD	_	30	auxpass	_	_
29	poorly	poorly	RB	RB	_	30	advmod	_	_
30	induced	induce	VBN	VBN	_	8	conj	_	_
31	by	by	IN	IN	_	33	case	_	_
32	phorbol	phorbol	NN	NN	_	33	compound	_	_
33	esters	ester	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	BAT	bat	NN	NN	_	10	compound	_	_
8	box	box	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	important	important	JJ	JJ	_	4	ccomp	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cell	cell	NN	NN	_	17	nmod:npmod	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	expression	expression	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	CD20	cd20	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	12	cc	_	_
22	perhaps	perhaps	RB	RB	_	23	advmod	_	_
23	CD21	cd21	NN	NN	_	12	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	jun-B	jun-b	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	target	target	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	autoreactive	autoreactive	JJ	JJ	_	8	amod	_	_
8	T-cells	t-cell	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	IDDM	iddm	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Target	target	NN	NN	_	2	compound	_	_
2	antigens	antigen	NNS	NNS	_	8	nsubj	_	_
3	defined	define	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	5	case	_	_
5	autoantibodies	autoantibody	NNS	NNS	_	3	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	IDDM	iddm	NN	NN	_	5	nmod	_	_
8	include	include	VBP	VBP	_	0	root	_	_
9	insulin	insulin	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	putative	putative	JJ	JJ	_	13	amod	_	_
13	glycolipid	glycolipid	NN	NN	_	9	conj	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	reacts	react	VBZ	VBZ	_	13	acl:relcl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	islet	islet	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	antibodies	antibody	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	a	a	DT	DT	_	24	det	_	_
23	64,000-M(r)	64,000-m(r)	JJ	JJ	_	24	amod	_	_
24	protein	protein	NN	NN	_	9	conj	_	_
25	recently	recently	RB	RB	_	26	advmod	_	_
26	identified	identify	VBN	VBN	_	24	acl	_	_
27	as	as	IN	IN	_	30	case	_	_
28	glutamic	glutamic	JJ	JJ	_	30	amod	_	_
29	acid	acid	NN	NN	_	30	compound	_	_
30	decarboxylase	decarboxylase	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	some	some	DT	DT	_	6	det	_	_
5	IDDM	iddm	NN	NN	_	6	compound	_	_
6	sera	sera	NN	NN	_	15	nsubj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	contain	contain	VBP	VBP	_	6	acl:relcl	_	_
9	antibodies	antibody	NNS	NNS	_	8	dobj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	glutamic	glutamic	JJ	JJ	_	13	amod	_	_
12	acid	acid	NN	NN	_	13	compound	_	_
13	decarboxylase	decarboxylase	NN	NN	_	9	nmod	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	coprecipitate	coprecipitate	VBP	VBP	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	38,000-M(r)	38,000-m(r)	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	15	dobj	_	_
19	from	from	IN	IN	_	20	case	_	_
20	islets	islet	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	used	use	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	high	high	JJ	JJ	_	8	amod	_	_
6	titer	titer	NN	NN	_	8	compound	_	_
7	anti-38,000-M(r)	anti-38,000-m(r)	JJ	JJ	_	8	amod	_	_
8	serum	serum	NN	NN	_	3	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	screen	screen	VB	VB	_	3	advcl	_	_
11	bacteriophage	bacteriophage	NN	NN	_	15	compound	_	_
12	lambda	lambda	NN	NN	_	15	compound	_	_
13	cDNA	cdna	NN	NN	_	15	compound	_	_
14	expression	expression	NN	NN	_	15	compound	_	_
15	libraries	library	NNS	NNS	_	10	dobj	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	identified	identify	VBD	VBD	_	3	conj	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	islet	islet	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	placental	placental	JJ	JJ	_	22	amod	_	_
22	clones	clone	NNS	NNS	_	19	conj	_	_
23	encoding	encode	VBG	VBG	_	19	acl	_	_
24	jun-B	jun-b	NN	NN	_	23	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	the	the	DT	DT	_	29	det	_	_
27	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	24	appos	_	_
30	,	,	,	,	_	24	punct	_	_
31	of	of	IN	IN	_	34	case	_	_
32	predicted	predict	VBN	VBN	_	34	amod	_	_
33	38,000	38,000	CD	CD	_	34	nummod	_	_
34	M(r)	m(r)	NN	NN	_	24	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	T-cells	t-cell	NNS	NNS	_	4	nsubj	_	_
4	exhibited	exhibit	VBD	VBD	_	0	root	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	proliferation	proliferation	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	response	response	NN	NN	_	12	dep	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	recombinant	recombinant	JJ	JJ	_	12	amod	_	_
12	fragment	fragment	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	jun-B	jun-b	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	amino	amino	NN	NN	_	17	compound	_	_
17	acids	acid	NNS	NNS	_	14	appos	_	_
18	1-180	1-180	CD	CD	_	17	nummod	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	in	in	IN	IN	_	30	case	_	_
21	12	12	CD	CD	_	23	compound	_	_
22	of	of	IN	IN	_	23	advmod	_	_
23	17	17	CD	CD	_	30	nummod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	71	71	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	23	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	recent-onset	recent-onset	JJ	JJ	_	30	amod	_	_
29	IDDM	iddm	NN	NN	_	30	compound	_	_
30	subjects	subject	NNS	NNS	_	14	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	8	8	CD	CD	_	34	compound	_	_
33	of	of	IN	IN	_	34	advmod	_	_
34	16	16	CD	CD	_	41	nummod	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	50	50	CD	CD	_	37	nummod	_	_
37	%	%	NN	NN	_	34	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	ICA-positive	ica-positive	JJ	JJ	_	41	amod	_	_
40	first-degree	first-degree	JJ	JJ	_	41	amod	_	_
41	relatives	relative	NNS	NNS	_	30	conj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	IDDM	iddm	NN	NN	_	44	compound	_	_
44	subjects	subject	NNS	NNS	_	41	nmod	_	_
45	who	who	WP	WP	_	48	nsubj	_	_
46	were	be	VBD	VBD	_	48	cop	_	_
47	at	at	IN	IN	_	48	case	_	_
48	risk	risk	NN	NN	_	44	acl:relcl	_	_
49	,	,	,	,	_	30	punct	_	_
50	3	3	CD	CD	_	52	compound	_	_
51	of	of	IN	IN	_	52	advmod	_	_
52	12	12	CD	CD	_	60	nummod	_	_
53	(	(	-LRB-	-LRB-	_	55	punct	_	_
54	25	25	CD	CD	_	55	nummod	_	_
55	%	%	NN	NN	_	52	dep	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	other	other	JJ	JJ	_	60	amod	_	_
58	autoimmune	autoimmune	JJ	JJ	_	60	amod	_	_
59	disease	disease	NN	NN	_	60	compound	_	_
60	subjects	subject	NNS	NNS	_	30	conj	_	_
61	,	,	,	,	_	30	punct	_	_
62	and	and	CC	CC	_	30	cc	_	_
63	0	0	CD	CD	_	65	compound	_	_
64	of	of	IN	IN	_	65	advmod	_	_
65	10	10	CD	CD	_	68	nummod	_	_
66	healthy	healthy	JJ	JJ	_	68	amod	_	_
67	control	control	NN	NN	_	68	compound	_	_
68	subjects	subject	NNS	NNS	_	30	conj	_	_
69	.	.	.	.	_	4	punct	_	_

1	Proliferation	proliferation	NN	NN	_	7	nsubj	_	_
2	to	to	TO	TO	_	4	case	_	_
3	tetanus	tetanus	NN	NN	_	4	compound	_	_
4	toxoid	toxoid	NN	NN	_	1	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	differ	differ	VB	VB	_	0	root	_	_
8	significantly	significantly	RB	RB	_	7	advmod	_	_
9	between	between	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	groups	group	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Responses	response	NNS	NNS	_	6	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	jun-B	jun-b	NN	NN	_	1	nmod	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	related	related	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	age	age	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	sex	sex	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	leukocyte	leukocyte	NN	NN	_	16	compound	_	_
15	antigen	antigen	NN	NN	_	16	compound	_	_
16	status	status	NN	NN	_	8	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	autoreactive	autoreactive	JJ	JJ	_	4	amod	_	_
4	T-cells	t-cell	NNS	NNS	_	5	nsubj	_	_
5	identify	identify	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	antigen	antigen	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	p38	p38	NN	NN	_	11	compound	_	_
11	jun-B	jun-b	NN	NN	_	8	appos	_	_
12	,	,	,	,	_	8	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	IDDM	iddm	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	appear	appear	VBP	VBP	_	5	conj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	indicate	indicate	VB	VB	_	16	xcomp	_	_
19	subjects	subject	NNS	NNS	_	18	dobj	_	_
20	at	at	IN	IN	_	21	case	_	_
21	risk	risk	NN	NN	_	19	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	development	development	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	clinical	clinical	JJ	JJ	_	27	amod	_	_
27	disease	disease	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin	interleukin	NN	NN	_	2	nmod	_	_
5	3	3	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL3	il3	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	13	case	_	_
10	primary	primary	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	AP-1-	ap-1-	NN	NN	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	octamer-binding	octamer-binding	JJ	JJ	_	3	conj	_	_
6	proteins	protein	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	control	control	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	IL3	il3	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	molecular	molecular	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	biochemical	biochemical	JJ	JJ	_	5	conj	_	_
8	basis	basis	NN	NN	_	3	dobj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	18	case	_	_
12	interleukin	interleukin	NN	NN	_	18	compound	_	_
13	3	3	CD	CD	_	12	nummod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL3	il3	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	10	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	primary	primary	JJ	JJ	_	23	amod	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
24	following	follow	VBG	VBG	_	28	case	_	_
25	CD3	cd3	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	CD2	cd2	NN	NN	_	25	conj	_	_
28	receptor	receptor	NN	NN	_	10	nmod	_	_
29	stimulation	stimulation	NN	NN	_	28	dep	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	activation	activation	NN	NN	_	29	conj	_	_
32	by	by	IN	IN	_	33	case	_	_
33	phytohemagglutinin	phytohemagglutinin	NN	NN	_	28	nmod	_	_
34	plus	plus	CC	CC	_	33	cc	_	_
35	phorbol	phorbol	NN	NN	_	37	compound	_	_
36	12-myristate	12-myristate	NN	NN	_	37	compound	_	_
37	13-acetate	13-acetate	NN	NN	_	33	conj	_	_
38	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	29	advcl	_	_
2	transfection	transfection	NN	NN	_	6	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	2	conj	_	_
6	assays	assay	NNS	NNS	_	1	dobj	_	_
7	specifically	specifically	RB	RB	_	8	advmod	_	_
8	designed	design	VBN	VBN	_	6	acl	_	_
9	for	for	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	18	case	_	_
14	conjunction	conjunction	NN	NN	_	18	dep	_	_
15	with	with	IN	IN	_	18	case	_	_
16	gel	gel	NN	NN	_	18	compound	_	_
17	retardation	retardation	NN	NN	_	18	compound	_	_
18	assays	assay	NNS	NNS	_	8	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	Western	western	NN	NN	_	22	compound	_	_
21	blot	blot	NN	NN	_	22	compound	_	_
22	analyses	analysis	NNS	NNS	_	18	conj	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	UV	uv	NN	NN	_	26	compound	_	_
25	cross-linking	cross-linking	JJ	JJ	_	26	amod	_	_
26	studies	study	NNS	NNS	_	18	conj	_	_
27	,	,	,	,	_	29	punct	_	_
28	we	we	PRP	PRP	_	29	nsubj	_	_
29	found	find	VBD	VBD	_	0	root	_	_
30	that	that	IN	IN	_	38	mark	_	_
31	c-Jun	c-jun	NN	NN	_	37	compound	_	_
32	,	,	,	,	_	31	punct	_	_
33	c-Fos	c-fos	NN	NN	_	31	conj	_	_
34	,	,	,	,	_	31	punct	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	octamer-binding	octamer-binding	NN	NN	_	31	conj	_	_
37	proteins	protein	NNS	NNS	_	38	nsubj	_	_
38	play	play	VBP	VBP	_	29	ccomp	_	_
39	a	a	DT	DT	_	41	det	_	_
40	major	major	JJ	JJ	_	41	amod	_	_
41	role	role	NN	NN	_	38	dobj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	transcriptional	transcriptional	JJ	JJ	_	44	amod	_	_
44	activation	activation	NN	NN	_	38	nmod	_	_
45	of	of	IN	IN	_	48	case	_	_
46	the	the	DT	DT	_	48	det	_	_
47	IL3	il3	NN	NN	_	48	compound	_	_
48	gene	gene	NN	NN	_	44	nmod	_	_
49	via	via	IN	IN	_	51	case	_	_
50	their	they	PRP$	PRP$	_	51	nmod:poss	_	_
51	interaction	interaction	NN	NN	_	38	nmod	_	_
52	with	with	IN	IN	_	55	case	_	_
53	two	two	CD	CD	_	55	nummod	_	_
54	specific	specific	JJ	JJ	_	55	amod	_	_
55	regions	region	NNS	NNS	_	51	nmod	_	_
56	contained	contain	VBN	VBN	_	55	acl	_	_
57	within	within	IN	IN	_	61	case	_	_
58	the	the	DT	DT	_	61	det	_	_
59	IL3	il3	NN	NN	_	61	compound	_	_
60	5'-flanking	5'-flanking	JJ	JJ	_	61	amod	_	_
61	sequence	sequence	NN	NN	_	56	nmod	_	_
62	.	.	.	.	_	29	punct	_	_

1	Additionally	additionally	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	region	region	NN	NN	_	21	nsubj	_	_
5	between	between	IN	IN	_	6	case	_	_
6	bases	basis	NNS	NNS	_	4	nmod	_	_
7	-107	-107	CD	CD	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	-59	-59	CD	CD	_	7	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL3	il3	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	6	nmod	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	putative	putative	JJ	JJ	_	20	amod	_	_
16	AP-2	ap-2	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Sp1	sp1	NN	NN	_	16	conj	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	motifs	motif	NNS	NNS	_	14	dobj	_	_
21	appears	appear	VBZ	VBZ	_	0	root	_	_
22	necessary	necessary	JJ	JJ	_	21	xcomp	_	_
23	for	for	IN	IN	_	26	case	_	_
24	basal	basal	JJ	JJ	_	26	amod	_	_
25	level	level	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	IL3	il3	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	indicate	indicate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	CD2	cd2	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	16	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	phytohemagglutinin	phytohemagglutinin	NN	NN	_	15	compound	_	_
11	plus	plus	CC	CC	_	10	cc	_	_
12	phorbol	phorbol	NN	NN	_	14	compound	_	_
13	12-myristate	12-myristate	NN	NN	_	14	compound	_	_
14	13-acetate	13-acetate	NN	NN	_	10	conj	_	_
15	stimulation	stimulation	NN	NN	_	8	conj	_	_
16	augment	augment	VBP	VBP	_	4	ccomp	_	_
17	T	t	NN	NN	_	21	compound	_	_
18	cell	cell	NN	NN	_	21	compound	_	_
19	IL3	il3	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	16	dobj	_	_
22	through	through	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	same	same	JJ	JJ	_	28	amod	_	_
25	cis-	cis-	JJ	JJ	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	trans-activating	trans-activating	JJ	JJ	_	25	conj	_	_
28	signals	signal	NNS	NNS	_	16	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	should	should	MD	MD	_	4	aux	_	_
4	contribute	contribute	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	better	better	JJR	JJR	_	8	amod	_	_
8	understanding	understanding	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	regulation	regulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	IL3	il3	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	zeta	zeta	NN	NN	_	8	compound	_	_
6	2	2	CD	CD	_	8	nummod	_	_
7	globin	globin	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	alpha	alpha	NN	NN	_	14	compound	_	_
12	globin	globin	NN	NN	_	14	compound	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	element	element	NN	NN	_	2	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HS-40	hs-40	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	:	:	:	:	_	2	punct	_	_
19	functional	functional	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	2	dep	_	_
21	of	of	IN	IN	_	25	case	_	_
22	specific	specific	JJ	JJ	_	24	amod	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	factor-DNA	factor-dna	JJ	JJ	_	25	amod	_	_
25	complexes	complex	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	12	case	_	_
7	human	human	JJ	JJ	_	12	amod	_	_
8	embryonic	embryonic	JJ	JJ	_	12	amod	_	_
9	zeta	zeta	NN	NN	_	12	compound	_	_
10	2	2	CD	CD	_	12	nummod	_	_
11	globin	globin	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	18	det	_	_
15	alpha	alpha	NN	NN	_	18	compound	_	_
16	globin	globin	NN	NN	_	18	compound	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	element	element	NN	NN	_	12	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HS-40	hs-40	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	located	located	JJ	JJ	_	18	amod	_	_
23	40	40	CD	CD	_	24	nummod	_	_
24	kb	kb	NN	NN	_	25	nmod:npmod	_	_
25	upstream	upstream	RB	RB	_	22	advmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	zeta	zeta	NN	NN	_	31	compound	_	_
29	2	2	CD	CD	_	31	nummod	_	_
30	globin	globin	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	transient	transient	JJ	JJ	_	7	amod	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	3	nmod	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	HS-40	hs-40	NN	NN	_	10	nsubj	_	_
10	behaved	behave	VBD	VBD	_	3	ccomp	_	_
11	as	as	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	authentic	authentic	JJ	JJ	_	14	amod	_	_
14	enhancer	enhancer	NN	NN	_	10	nmod	_	_
15	for	for	IN	IN	_	21	case	_	_
16	high-level	high-level	JJ	JJ	_	21	amod	_	_
17	zeta	zeta	NN	NN	_	21	compound	_	_
18	2	2	CD	CD	_	21	nummod	_	_
19	globin	globin	NN	NN	_	21	compound	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	14	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	K562	k562	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	14	punct	_	_
26	an	a	DT	DT	_	29	det	_	_
27	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	14	appos	_	_
30	of	of	IN	IN	_	34	case	_	_
31	embryonic	embryonic	JJ	JJ	_	34	amod	_	_
32	and/or	and/or	CC	CC	_	31	cc	_	_
33	fetal	fetal	JJ	JJ	_	31	conj	_	_
34	origin	origin	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	15	mark	_	_
2	sequences	sequence	NNS	NNS	_	15	nsubj	_	_
3	located	located	JJ	JJ	_	2	amod	_	_
4	between	between	IN	IN	_	5	case	_	_
5	-559	-559	CD	CD	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	-88	-88	CD	CD	_	5	conj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	zeta	zeta	NN	NN	_	13	compound	_	_
11	2	2	CD	CD	_	13	nummod	_	_
12	globin	globin	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	5	nmod	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	dispensable	dispensable	JJ	JJ	_	25	advcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	21	case	_	_
20	enhancerless	enhancerless	NN	NN	_	21	compound	_	_
21	plasmids	plasmid	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	they	they	PRP	PRP	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	required	require	VBN	VBN	_	0	root	_	_
26	for	for	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	HS-40	hs-40	NN	NN	_	29	nmod:npmod	_	_
29	enhancer-mediated	enhancer-mediated	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	zeta	zeta	NN	NN	_	36	compound	_	_
34	2	2	CD	CD	_	36	nummod	_	_
35	globin	globin	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	25	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	this	this	DT	DT	_	11	det	_	_
6	HS-40	hs-40	NN	NN	_	10	dep	_	_
7	enhancer-zeta	enhancer-zeta	NN	NN	_	10	dep	_	_
8	2	2	CD	CD	_	10	compound	_	_
9	globin	globin	NN	NN	_	10	dep	_	_
10	promoter	promoter	NN	NN	_	11	amod	_	_
11	interaction	interaction	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	two	two	CD	CD	_	20	nummod	_	_
17	GATA-1	gata-1	NN	NN	_	20	compound	_	_
18	factor	factor	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	motifs	motif	NNS	NNS	_	13	nmod	_	_
21	located	located	JJ	JJ	_	20	amod	_	_
22	at	at	IN	IN	_	23	case	_	_
23	-230	-230	CD	CD	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	-104	-104	CD	CD	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	respectively	respectively	RB	RB	_	23	advmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	domains	domain	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HS-40	hs-40	NN	NN	_	3	nmod	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	mapped	map	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Bal	bal	NN	NN	_	5	compound	_	_
2	31	31	CD	CD	_	5	nummod	_	_
3	deletion	deletion	NN	NN	_	5	compound	_	_
4	mapping	map	VBG	VBG	_	5	amod	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	21	mark	_	_
8	one	one	CD	CD	_	10	nummod	_	_
9	GATA-1	gata-1	NN	NN	_	10	compound	_	_
10	motif	motif	NN	NN	_	21	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	one	one	CD	CD	_	14	nummod	_	_
13	GT	gt	NN	NN	_	14	compound	_	_
14	motif	motif	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	NF-E2/AP1	nf-e2/ap1	NN	NN	_	19	compound	_	_
19	motifs	motif	NNS	NNS	_	10	conj	_	_
20	together	together	RB	RB	_	10	advmod	_	_
21	formed	form	VBD	VBD	_	6	ccomp	_	_
22	the	the	DT	DT	_	24	det	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	core	core	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	HS-40	hs-40	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	erythroid-specific	erythroid-specific	JJ	JJ	_	30	amod	_	_
30	activation	activation	NN	NN	_	21	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	zeta	zeta	NN	NN	_	36	compound	_	_
34	2	2	CD	CD	_	36	nummod	_	_
35	globin	globin	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	4	nsubj	_	_
3	further	further	RBR	RBR	_	4	advmod	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	enhancer	enhancer	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	19	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	one	one	CD	CD	_	8	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	NF-E2/AP1	nf-e2/ap1	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HS-40	hs-40	NN	NN	_	15	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	mediated	mediate	VBN	VBN	_	4	ccomp	_	_
20	through	through	IN	IN	_	22	case	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	binding	binding	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	NF-E2	nf-e2	NN	NN	_	22	nmod	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	24	cc	_	_
27	AP1	ap1	NN	NN	_	29	compound	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	24	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	did	do	VBD	VBD	_	0	root	_	_
5	genomic	genomic	JJ	JJ	_	6	amod	_	_
6	footprinting	footprinting	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	HS-40	hs-40	NN	NN	_	11	compound	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	K562	k562	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	adult	adult	JJ	JJ	_	18	amod	_	_
17	nucleated	nucleated	JJ	JJ	_	18	amod	_	_
18	erythroblasts	erythroblast	NNS	NNS	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	different	different	JJ	JJ	_	23	amod	_	_
22	nonerythroid	nonerythroid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	14	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	motifs	motif	NNS	NNS	_	18	nsubj	_	_
4	within	within	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	core	core	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	HS-40	hs-40	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	as	as	IN	IN	_	12	mark	_	_
12	mapped	map	VBN	VBN	_	3	dep	_	_
13	by	by	IN	IN	_	16	case	_	_
14	transient	transient	JJ	JJ	_	16	amod	_	_
15	expression	expression	NN	NN	_	16	compound	_	_
16	analysis	analysis	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	appeared	appear	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	bind	bind	VB	VB	_	18	xcomp	_	_
21	a	a	DT	DT	_	25	det	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	s	s	NNS	NNS	_	20	dobj	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	30	case	_	_
28	living	live	VBG	VBG	_	30	amod	_	_
29	K562	k562	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	but	but	CC	CC	_	30	cc	_	_
32	not	not	RB	RB	_	35	neg	_	_
33	in	in	IN	IN	_	35	case	_	_
34	nonerythroid	nonerythroid	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	30	conj	_	_
36	.	.	.	.	_	18	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	one	one	CD	CD	_	15	nsubjpass	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	apparently	apparently	RB	RB	_	11	advmod	_	_
11	nonfunctional	nonfunctional	JJ	JJ	_	13	amod	_	_
12	sequence	sequence	NN	NN	_	13	compound	_	_
13	motifs	motif	NNS	NNS	_	7	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	bound	bind	VBN	VBN	_	0	root	_	_
16	with	with	IN	IN	_	17	case	_	_
17	factors	factor	NNS	NNS	_	15	nmod	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vivo	vivo	FW	FW	_	15	advmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	comparison	comparison	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	K562	k562	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	nucleated	nucleated	JJ	JJ	_	7	amod	_	_
7	erythroblasts	erythroblast	NNS	NNS	_	13	nsubj	_	_
8	from	from	IN	IN	_	12	case	_	_
9	adult	adult	JJ	JJ	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	bone	bone	NN	NN	_	12	compound	_	_
12	marrow	marrow	NN	NN	_	7	nmod	_	_
13	exhibited	exhibit	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	18	det	_	_
15	similar	similar	JJ	JJ	_	18	amod	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	nonidentical	nonidentical	JJ	JJ	_	15	conj	_	_
18	pattern	pattern	NN	NN	_	13	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	18	nmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vivo	vivo	FW	FW	_	22	advmod	_	_
25	at	at	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	HS-40	hs-40	NN	NN	_	28	compound	_	_
28	region	region	NN	NN	_	13	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	21	nsubjpass	_	_
7	of	of	IN	IN	_	13	case	_	_
8	human	human	JJ	JJ	_	13	amod	_	_
9	embryonic	embryonic	JJ	JJ	_	13	amod	_	_
10	zeta	zeta	NN	NN	_	13	compound	_	_
11	2	2	CD	CD	_	13	nummod	_	_
12	globin	globin	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	6	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	19	det	_	_
16	fetal/adult	fetal/adult	JJ	JJ	_	19	amod	_	_
17	alpha	alpha	NN	NN	_	19	compound	_	_
18	globin	globin	NN	NN	_	19	compound	_	_
19	genes	gene	NNS	NNS	_	13	conj	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
22	by	by	IN	IN	_	30	case	_	_
23	erythroid	erythroid	JJ	JJ	_	24	amod	_	_
24	cell-specific	cell-specific	JJ	JJ	_	29	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	developmental	developmental	JJ	JJ	_	27	amod	_	_
27	stage-specific	stage-specific	JJ	JJ	_	24	conj	_	_
28	nuclear	nuclear	JJ	JJ	_	29	dep	_	_
29	factor-DNA	factor-dna	NN	NN	_	30	amod	_	_
30	complexes	complex	NNS	NNS	_	21	nmod	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	form	form	VBP	VBP	_	30	acl:relcl	_	_
33	at	at	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	enhancer	enhancer	NN	NN	_	32	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	HS-40	hs-40	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	the	the	DT	DT	_	42	det	_	_
41	globin	globin	NN	NN	_	42	compound	_	_
42	promoters	promoter	NNS	NNS	_	35	conj	_	_
43	.	.	.	.	_	3	punct	_	_

1	Interaction	interaction	NN	NN	_	10	nsubj	_	_
2	between	between	IN	IN	_	9	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B-	b-	NN	NN	_	9	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	serum	serum	NN	NN	_	8	nmod:npmod	_	_
7	response	response	NN	NN	_	8	nmod:npmod	_	_
8	factor-binding	factor-binding	JJ	JJ	_	4	conj	_	_
9	elements	element	NNS	NNS	_	1	nmod	_	_
10	activates	activate	VBZ	VBZ	_	0	root	_	_
11	an	a	DT	DT	_	15	det	_	_
12	interleukin-2	interleukin-2	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	alpha-chain	alpha-chain	JJ	JJ	_	15	amod	_	_
15	enhancer	enhancer	NN	NN	_	10	dobj	_	_
16	specifically	specifically	RB	RB	_	10	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	26	mark	_	_
4	a	a	DT	DT	_	7	det	_	_
5	short	short	JJ	JJ	_	7	amod	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	26	nsubjpass	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	13	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	dobj	_	_
14	from	from	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	interleukin-2	interleukin-2	NN	NN	_	19	compound	_	_
17	receptor	receptor	NN	NN	_	19	compound	_	_
18	alpha-chain	alpha-chain	JJ	JJ	_	19	amod	_	_
19	gene	gene	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	IL-2R	il-2r	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	preferentially	preferentially	RB	RB	_	26	advmod	_	_
26	activated	activate	VBN	VBN	_	2	ccomp	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IL-2R	il-2r	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	enhancer	enhancer	NN	NN	_	5	nsubj	_	_
5	binds	bind	VBZ	VBZ	_	0	root	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	5	dobj	_	_
8	poorly	poorly	RB	RB	_	5	advmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	is	be	VBZ	VBZ	_	13	auxpass	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	weakly	weakly	RB	RB	_	13	advmod	_	_
13	activated	activate	VBN	VBN	_	5	conj	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	alone	alone	RB	RB	_	18	advmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Serum	serum	NN	NN	_	3	compound	_	_
2	response	response	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	SRF	srf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	binds	bind	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	site	site	NN	NN	_	7	nmod	_	_
11	adjacent	adjacent	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-2R	il-2r	NN	NN	_	20	compound	_	_
20	enhancer	enhancer	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	7	punct	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	both	both	DT	DT	_	24	det	_	_
24	sites	site	NNS	NNS	_	26	nsubj	_	_
25	together	together	RB	RB	_	24	advmod	_	_
26	have	have	VBP	VBP	_	7	conj	_	_
27	strong	strong	JJ	JJ	_	29	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	26	dobj	_	_
30	specifically	specifically	RB	RB	_	26	advmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	26	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	levels	level	NNS	NNS	_	14	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	SRF	srf	NN	NN	_	4	nmod	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	consistently	consistently	RB	RB	_	14	advmod	_	_
14	higher	higher	JJR	JJR	_	0	root	_	_
15	than	than	IN	IN	_	19	case	_	_
16	in	in	IN	IN	_	19	case	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	types	type	NNS	NNS	_	14	advcl	_	_
20	.	.	.	.	_	14	punct	_	_

1	Overexpression	overexpression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	SRF	srf	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	causes	cause	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IL-2R	il-2r	NN	NN	_	10	compound	_	_
10	enhancer	enhancer	NN	NN	_	7	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	function	function	VB	VB	_	7	xcomp	_	_
13	as	as	RB	RB	_	20	advmod	_	_
14	well	well	RB	RB	_	20	advmod	_	_
15	as	as	IN	IN	_	20	mark	_	_
16	it	it	PRP	PRP	_	20	nsubj	_	_
17	does	do	VBZ	VBZ	_	20	aux	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	7	advcl	_	_
21	,	,	,	,	_	7	punct	_	_
22	suggesting	suggest	VBG	VBG	_	7	xcomp	_	_
23	that	that	IN	IN	_	35	mark	_	_
24	the	the	DT	DT	_	26	det	_	_
25	high	high	JJ	JJ	_	26	amod	_	_
26	level	level	NN	NN	_	35	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	SRF	srf	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	is	be	VBZ	VBZ	_	35	cop	_	_
34	functionally	functionally	RB	RB	_	35	advmod	_	_
35	important	important	JJ	JJ	_	22	ccomp	_	_
36	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcriptionally	transcriptionally	RB	RB	_	3	advmod	_	_
3	active	active	JJ	JJ	_	4	amod	_	_
4	factors	factor	NNS	NNS	_	20	nsubj	_	_
5	mediating	mediate	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	HTLV-I	htlv-i	NN	NN	_	12	compound	_	_
11	Tax	tax	NN	NN	_	12	compound	_	_
12	transactivator	transactivator	NN	NN	_	7	nmod	_	_
13	on	on	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	IL-2R	il-2r	NN	NN	_	19	compound	_	_
16	alpha	alpha	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	enhancer	enhancer	NN	NN	_	7	nmod	_	_
20	include	include	VBP	VBP	_	0	root	_	_
21	the	the	DT	DT	_	22	det	_	_
22	product	product	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	c-rel	c-rel	NN	NN	_	26	compound	_	_
26	proto-oncogene	proto-oncogene	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transactivator	transactivator	NN	NN	_	4	compound	_	_
3	HTLV-I	htlv-i	NN	NN	_	4	compound	_	_
4	Tax	tax	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	promoter	promoter	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	gene	gene	NN	NN	_	7	nmod	_	_
11	coding	code	VBG	VBG	_	10	acl	_	_
12	for	for	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	interleukin	interleukin	NN	NN	_	17	compound	_	_
15	2	2	CD	CD	_	17	nummod	_	_
16	alpha-chain	alpha-chain	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	11	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	IL-2R	il-2r	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	via	via	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	kappa	kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	11	nmod	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	can	can	MD	MD	_	29	aux	_	_
29	bind	bind	VB	VB	_	26	acl:relcl	_	_
30	several	several	JJ	JJ	_	32	amod	_	_
31	protein	protein	NN	NN	_	32	compound	_	_
32	species	species	NNS	NNS	_	29	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	rel	rel	NN	NN	_	36	compound	_	_
36	family	family	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	Tax1	tax1	NN	NN	_	3	nsubj	_	_
2	strongly	strongly	RB	RB	_	3	advmod	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	motif	motif	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	in	in	IN	IN	_	18	case	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	HeLa	hela	NN	NN	_	18	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	Jurkat	jurkat	NN	NN	_	14	conj	_	_
18	cells	cell	NNS	NNS	_	3	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	undifferentiated	undifferentiated	JJ	JJ	_	10	amod	_	_
8	embryocarcinoma	embryocarcinoma	NN	NN	_	10	compound	_	_
9	F9	f9	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Overexpression	overexpression	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	p50	p50	NN	NN	_	9	compound	_	_
5	,	,	,	,	_	4	punct	_	_
6	p65	p65	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	Rel	rel	NN	NN	_	4	conj	_	_
9	proteins	protein	NNS	NNS	_	1	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	25	mark	_	_
15	significant	significant	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	25	nsubjpass	_	_
17	of	of	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	IL-2R	il-2r	NN	NN	_	23	compound	_	_
20	alpha	alpha	NN	NN	_	23	compound	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	16	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	observed	observe	VBN	VBN	_	13	ccomp	_	_
26	only	only	RB	RB	_	28	advmod	_	_
27	with	with	IN	IN	_	28	case	_	_
28	Rel	rel	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	Rel	rel	NN	NN	_	28	conj	_	_
31	plus	plus	CC	CC	_	30	cc	_	_
32	p65	p65	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	13	punct	_	_

1	Moreover	moreover	RB	RB	_	34	advmod	_	_
2	,	,	,	,	_	34	punct	_	_
3	whereas	whereas	IN	IN	_	14	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	Tax	tax	NN	NN	_	14	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	phorbol	phorbol	NN	NN	_	9	compound	_	_
8	12-myristate	12-myristate	NN	NN	_	9	compound	_	_
9	13-acetate	13-acetate	NN	NN	_	5	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PMA	pma	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	able	able	JJ	JJ	_	34	advcl	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	efficiently	efficiently	RB	RB	_	17	advmod	_	_
17	induce	induce	VB	VB	_	14	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	binding	binding	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	29	case	_	_
24	the	the	DT	DT	_	29	det	_	_
25	IL-2R	il-2r	NN	NN	_	29	compound	_	_
26	alpha	alpha	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	19	nmod	_	_
30	,	,	,	,	_	34	punct	_	_
31	PMA	pma	NN	NN	_	34	nsubj	_	_
32	is	be	VBZ	VBZ	_	34	cop	_	_
33	functionally	functionally	RB	RB	_	34	advmod	_	_
34	inactive	inactive	JJ	JJ	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	Using	use	VBG	VBG	_	9	advcl	_	_
2	the	the	DT	DT	_	6	det	_	_
3	DNA	dna	NN	NN	_	6	compound	_	_
4	affinity	affinity	NN	NN	_	6	compound	_	_
5	precipitation	precipitation	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	1	dobj	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	observed	observe	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	Tax1	tax1	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	able	able	JJ	JJ	_	9	ccomp	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	efficiently	efficiently	RB	RB	_	16	advmod	_	_
16	induce	induce	VB	VB	_	13	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	binding	binding	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Rel	rel	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	whereas	whereas	IN	IN	_	13	dep	_	_
23	PMA	pma	NN	NN	_	24	nsubj	_	_
24	is	be	VBZ	VBZ	_	13	parataxis	_	_
25	not	not	RB	RB	_	24	neg	_	_
26	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	established	establish	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	clear	clear	JJ	JJ	_	5	amod	_	_
5	difference	difference	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	both	both	DT	DT	_	8	det	_	_
8	stimuli	stimulus	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	indicating	indicate	VBG	VBG	_	2	advcl	_	_
11	that	that	IN	IN	_	17	mark	_	_
12	Rel	rel	NN	NN	_	17	nsubj	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	the	the	DT	DT	_	17	det	_	_
15	functionally	functionally	RB	RB	_	16	advmod	_	_
16	active	active	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	10	ccomp	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	17	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	members	member	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	rel	rel	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	11	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	regulated	regulate	VBN	VBN	_	2	ccomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	interaction	interaction	NN	NN	_	17	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	DNA	dna	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	that	that	IN	IN	_	31	mark	_	_
25	Rel	rel	NN	NN	_	31	nsubj	_	_
26	can	can	MD	MD	_	31	aux	_	_
27	be	be	VB	VB	_	31	cop	_	_
28	a	a	DT	DT	_	31	det	_	_
29	potent	potent	JJ	JJ	_	31	amod	_	_
30	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
31	activator	activator	NN	NN	_	17	conj	_	_
32	on	on	IN	IN	_	36	case	_	_
33	specific	specific	JJ	JJ	_	36	amod	_	_
34	kappa	kappa	NN	NN	_	36	compound	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	sites	site	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	nsubj	_	_
3	controls	control	VBZ	VBZ	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	inhibitor	inhibitor	NN	NN	_	10	compound	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	4	nmod	_	_
11	:	:	:	:	_	3	punct	_	_
12	evidence	evidence	NN	NN	_	3	dep	_	_
13	for	for	IN	IN	_	17	case	_	_
14	an	a	DT	DT	_	17	det	_	_
15	inducible	inducible	JJ	JJ	_	17	amod	_	_
16	autoregulatory	autoregulatory	JJ	JJ	_	17	amod	_	_
17	pathway	pathway	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	eukaryotic	eukaryotic	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	12	nsubj	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	factor-kappa	factor-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	dep	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	participates	participate	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	many	many	JJ	JJ	_	15	amod	_	_
15	parts	part	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	genetic	genetic	JJ	JJ	_	19	amod	_	_
19	program	program	NN	NN	_	15	nmod	_	_
20	mediating	mediate	VBG	VBG	_	19	acl	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocyte	lymphocyte	NN	NN	_	20	dobj	_	_
23	activation	activation	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	growth	growth	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	occurs	occur	VBZ	VBZ	_	0	root	_	_
7	after	after	IN	IN	_	10	case	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	induced	induce	VBN	VBN	_	10	amod	_	_
10	dissociation	dissociation	NN	NN	_	6	nmod	_	_
11	from	from	IN	IN	_	18	case	_	_
12	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
14	inhibitor	inhibitor	NN	NN	_	18	compound	_	_
15	I	i	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	ester	ester	NN	NN	_	7	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	tumor	tumor	NN	NN	_	6	compound	_	_
5	necrosis	necrosis	NN	NN	_	6	compound	_	_
6	factor-alpha	factor-alpha	NN	NN	_	2	conj	_	_
7	induction	induction	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	17	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	degradation	degradation	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	performed	perform	VBN	VBN	_	23	amod	_	_
20	I	i	NN	NN	_	23	compound	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activation	activation	NN	NN	_	17	conj	_	_
27	of	of	IN	IN	_	33	case	_	_
28	I	i	NN	NN	_	33	compound	_	_
29	kappa	kappa	NN	NN	_	33	compound	_	_
30	B	b	NN	NN	_	33	compound	_	_
31	alpha	alpha	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	13	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	I	i	NN	NN	_	10	compound	_	_
7	kappa	kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	specifically	specifically	RB	RB	_	13	advmod	_	_
13	induced	induce	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	65-kilodalton	65-kilodalton	JJ	JJ	_	18	amod	_	_
17	transactivating	transactivate	VBG	VBG	_	18	amod	_	_
18	subunit	subunit	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Association	association	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	newly	newly	RB	RB	_	5	advmod	_	_
5	synthesized	synthesize	VBN	VBN	_	9	amod	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	1	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	p65	p65	NN	NN	_	1	nmod	_	_
12	restores	restore	VBZ	VBZ	_	0	root	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	inhibition	inhibition	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
17	B	b	NN	NN	_	20	compound	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	12	cc	_	_
22	prolongs	prolong	VBZ	VBZ	_	12	conj	_	_
23	the	the	DT	DT	_	24	det	_	_
24	survival	survival	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	this	this	DT	DT	_	28	det	_	_
27	labile	labile	JJ	JJ	_	28	amod	_	_
28	inhibitor	inhibitor	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	nsubj	_	_
9	controls	control	VBZ	VBZ	_	5	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	11	nmod	_	_
17	by	by	IN	IN	_	23	case	_	_
18	means	means	NNS	NNS	_	23	dep	_	_
19	of	of	IN	IN	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	inducible	inducible	JJ	JJ	_	23	amod	_	_
22	autoregulatory	autoregulatory	JJ	JJ	_	23	amod	_	_
23	pathway	pathway	NN	NN	_	9	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	p105	p105	NN	NN	_	5	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p98	p98	NN	NN	_	1	conj	_	_
4	precursor	precursor	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	6	nsubj	_	_
6	play	play	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	active	active	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	nmod:npmod	_	_
12	B-mediated	b-mediated	JJ	JJ	_	14	amod	_	_
13	signal	signal	NN	NN	_	14	compound	_	_
14	transduction	transduction	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	family	family	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	composed	compose	VBN	VBN	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	two	two	CD	CD	_	13	nummod	_	_
12	distinct	distinct	JJ	JJ	_	13	amod	_	_
13	subgroups	subgroup	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	proteins	protein	NNS	NNS	_	13	appos	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	undergo	undergo	VBP	VBP	_	15	acl:relcl	_	_
18	proteolytic	proteolytic	JJ	JJ	_	19	amod	_	_
19	processing	processing	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	contain	contain	VBP	VBP	_	17	conj	_	_
22	SWI6/ankyrin	swi6/ankyrin	NN	NN	_	23	compound	_	_
23	repeats	repeat	NNS	NNS	_	21	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	carboxyl	carboxyl	NN	NN	_	27	compound	_	_
27	termini	terminus	NNS	NNS	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	p105	p105	NN	NN	_	15	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	p98	p98	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	,	,	,	,	_	15	punct	_	_
34	and	and	CC	CC	_	15	cc	_	_
35	those	those	DT	DT	_	15	conj	_	_
36	without	without	IN	IN	_	38	case	_	_
37	such	such	JJ	JJ	_	38	amod	_	_
38	repeats	repeat	NNS	NNS	_	35	nmod	_	_
39	that	that	WDT	WDT	_	42	nsubj	_	_
40	do	do	VBP	VBP	_	42	aux	_	_
41	not	not	RB	RB	_	42	neg	_	_
42	require	require	VB	VB	_	35	acl:relcl	_	_
43	processing	processing	NN	NN	_	42	dobj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	p65	p65	NN	NN	_	35	dep	_	_
46	,	,	,	,	_	45	punct	_	_
47	c-Rel	c-rel	NN	NN	_	45	conj	_	_
48	,	,	,	,	_	45	punct	_	_
49	RelB	relb	NN	NN	_	45	conj	_	_
50	,	,	,	,	_	45	punct	_	_
51	and	and	CC	CC	_	45	cc	_	_
52	Dorsal	dorsal	NN	NN	_	45	conj	_	_
53	)	)	-RRB-	-RRB-	_	45	punct	_	_
54	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	p105	p105	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p98	p98	NN	NN	_	5	conj	_	_
8	precursors	precursor	NNS	NNS	_	9	nsubj	_	_
9	share	share	VBP	VBP	_	2	ccomp	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	properties	property	NNS	NNS	_	9	dobj	_	_
12	with	with	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	9	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	contain	contain	VBP	VBP	_	17	acl:relcl	_	_
22	SWI6/ankyrin	swi6/ankyrin	NN	NN	_	23	compound	_	_
23	repeats	repeat	NNS	NNS	_	21	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	p105	p105	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	p98	p98	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	form	form	VB	VB	_	6	xcomp	_	_
9	stable	stable	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	8	dobj	_	_
11	with	with	IN	IN	_	16	case	_	_
12	other	other	JJ	JJ	_	16	amod	_	_
13	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	16	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	family	family	NN	NN	_	16	compound	_	_
16	members	member	NNS	NNS	_	8	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	19	case	_	_
19	p65	p65	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	c-Rel	c-rel	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	Association	association	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	precursors	precursor	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	sufficient	sufficient	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	9	amod	_	_
9	retention	retention	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	p65	p65	NN	NN	_	9	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	c-Rel	c-rel	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	both	both	DT	DT	_	21	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	16	nmod	_	_
19	are	be	VBP	VBP	_	21	cop	_	_
20	otherwise	otherwise	RB	RB	_	21	advmod	_	_
21	nuclear	nuclear	JJ	JJ	_	12	acl:relcl	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	complexes	complex	NNS	NNS	_	3	nsubj	_	_
3	undergo	undergo	VBP	VBP	_	0	root	_	_
4	stimulus-responsive	stimulus-responsive	JJ	JJ	_	5	amod	_	_
5	processing	processing	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	produce	produce	VB	VB	_	3	advcl	_	_
8	active	active	JJ	JJ	_	12	amod	_	_
9	p50/c-Rel	p50/c-rel	NN	NN	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p55/c-Rel	p55/c-rel	NN	NN	_	9	conj	_	_
12	complexes	complex	NNS	NNS	_	7	dobj	_	_
13	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	second	second	JJ	JJ	_	6	amod	_	_
6	pathway	pathway	NN	NN	_	3	dobj	_	_
7	leading	lead	VBG	VBG	_	6	acl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	26	nmod	_	_
15	processing	processing	NN	NN	_	26	nsubj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	precursors	precursor	NNS	NNS	_	15	nmod	_	_
19	rather	rather	RB	RB	_	15	cc	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	phosphorylation	phosphorylation	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	I	i	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	21	nmod	_	_
26	plays	play	VBZ	VBZ	_	6	acl:relcl	_	_
27	a	a	DT	DT	_	29	det	_	_
28	major	major	JJ	JJ	_	29	amod	_	_
29	role	role	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Mutual	mutual	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
6	activator	activator	NN	NN	_	8	compound	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	inhibitor	inhibitor	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B-alpha	b-alpha	NN	NN	_	11	appos	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	NK-kappa	nk-kappa	NN	NN	_	6	compound	_	_
3	B	b	NN	NN	_	6	compound	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	sequestered	sequester	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cytoplasm	cytoplasm	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	8	nmod	_	_
16	I	i	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B-alpha	b-alpha	NN	NN	_	15	dep	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	MAD-3	mad-3	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	8	punct	_	_

1	Various	various	JJ	JJ	_	3	amod	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	stimuli	stimulus	NNS	NNS	_	4	nsubj	_	_
4	relieve	relieve	VBP	VBP	_	0	root	_	_
5	this	this	DT	DT	_	6	det	_	_
6	inhibition	inhibition	NN	NN	_	4	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
9	largely	largely	RB	RB	_	10	advmod	_	_
10	unknown	unknown	JJ	JJ	_	8	amod	_	_
11	,	,	,	,	_	4	punct	_	_
12	leading	lead	VBG	VBG	_	4	advcl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	localization	localization	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	transactivation	transactivation	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	target	target	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	monocytes	monocyte	NNS	NNS	_	8	conj	_	_
11	that	that	IN	IN	_	25	mark	_	_
12	different	different	JJ	JJ	_	13	amod	_	_
13	stimuli	stimulus	NNS	NNS	_	25	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	including	include	VBG	VBG	_	19	case	_	_
16	tumor	tumor	NN	NN	_	19	compound	_	_
17	necrosis	necrosis	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	phorbol	phorbol	NN	NN	_	23	compound	_	_
22	12-myristate	12-myristate	NN	NN	_	23	compound	_	_
23	13-acetate	13-acetate	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	13	punct	_	_
25	cause	cause	VB	VB	_	3	ccomp	_	_
26	rapid	rapid	JJ	JJ	_	27	amod	_	_
27	degradation	degradation	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	I	i	NN	NN	_	31	compound	_	_
30	kappa	kappa	NN	NN	_	31	compound	_	_
31	B-alpha	b-alpha	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	25	punct	_	_
33	with	with	IN	IN	_	35	case	_	_
34	concomitant	concomitant	JJ	JJ	_	35	amod	_	_
35	activation	activation	NN	NN	_	25	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	35	nmod	_	_
39	,	,	,	,	_	25	punct	_	_
40	followed	follow	VBN	VBN	_	25	advcl	_	_
41	by	by	IN	IN	_	44	case	_	_
42	a	a	DT	DT	_	44	det	_	_
43	dramatic	dramatic	JJ	JJ	_	44	amod	_	_
44	increase	increase	NN	NN	_	40	nmod	_	_
45	in	in	IN	IN	_	52	case	_	_
46	I	i	NN	NN	_	52	compound	_	_
47	kappa	kappa	NN	NN	_	52	compound	_	_
48	B-alpha	b-alpha	NN	NN	_	52	compound	_	_
49	mRNA	mrna	NN	NN	_	52	compound	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	protein	protein	NN	NN	_	49	conj	_	_
52	synthesis	synthesis	NN	NN	_	44	nmod	_	_
53	.	.	.	.	_	3	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B-alpha	b-alpha	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	16	nsubjpass	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	encoded	encode	VBN	VBN	_	13	amod	_	_
13	protein	protein	NN	NN	_	9	conj	_	_
14	are	be	VBP	VBP	_	16	auxpass	_	_
15	potently	potently	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	3	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	by	by	IN	IN	_	22	case	_	_
22	homodimers	homodimer	NNS	NNS	_	19	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p65	p65	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	of	of	IN	IN	_	27	case	_	_
27	c-Rel	c-rel	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	14	nmod	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	14	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	I	i	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B-alpha	b-alpha	NN	NN	_	8	conj	_	_
13	mutually	mutually	RB	RB	_	14	advmod	_	_
14	regulate	regulate	VBP	VBP	_	4	acl:relcl	_	_
15	each	each	DT	DT	_	16	det	_	_
16	other	other	JJ	JJ	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	cycle	cycle	NN	NN	_	14	nmod	_	_
20	:	:	:	:	_	2	punct	_	_
21	saturating	saturating	JJ	JJ	_	22	amod	_	_
22	amounts	amount	NNS	NNS	_	31	nsubjpass	_	_
23	of	of	IN	IN	_	29	case	_	_
24	the	the	DT	DT	_	29	det	_	_
25	inhibitory	inhibitory	JJ	JJ	_	29	amod	_	_
26	I	i	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B-alpha	b-alpha	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	22	nmod	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	destroyed	destroy	VBN	VBN	_	2	parataxis	_	_
32	upon	upon	IN	IN	_	33	case	_	_
33	stimulation	stimulation	NN	NN	_	31	nmod	_	_
34	,	,	,	,	_	31	punct	_	_
35	allowing	allow	VBG	VBG	_	31	xcomp	_	_
36	rapid	rapid	JJ	JJ	_	37	dep	_	_
37	activation	activation	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	31	punct	_	_

1	Subsequently	subsequently	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	I	i	NN	NN	_	9	compound	_	_
4	kappa	kappa	NN	NN	_	9	compound	_	_
5	B-alpha	b-alpha	NN	NN	_	9	compound	_	_
6	mRNA	mrna	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	protein	protein	NN	NN	_	6	conj	_	_
9	levels	level	NNS	NNS	_	12	nsubjpass	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	quickly	quickly	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	resurgence	resurgence	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	I	i	NN	NN	_	7	compound	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B-alpha	b-alpha	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	acts	act	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	restore	restore	VB	VB	_	8	xcomp	_	_
11	an	a	DT	DT	_	12	det	_	_
12	equilibrium	equilibrium	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	19	nmod	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	19	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	again	again	RB	RB	_	19	advmod	_	_
19	inhibited	inhibit	VBN	VBN	_	12	acl:relcl	_	_
20	.	.	.	.	_	8	punct	_	_

1	Induced	induce	VBN	VBN	_	3	amod	_	_
2	myeloid	myeloid	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	K562	k562	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	downregulation	downregulation	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	erythroid	erythroid	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	megakaryocytic	megakaryocytic	JJ	JJ	_	10	conj	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	8	nmod	_	_
15	:	:	:	:	_	3	punct	_	_
16	a	a	DT	DT	_	19	det	_	_
17	novel	novel	JJ	JJ	_	19	amod	_	_
18	experimental	experimental	JJ	JJ	_	19	amod	_	_
19	model	model	NN	NN	_	3	dep	_	_
20	for	for	IN	IN	_	23	case	_	_
21	hemopoietic	hemopoietic	JJ	JJ	_	23	amod	_	_
22	lineage	lineage	NN	NN	_	23	compound	_	_
23	restriction	restriction	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	erythroleukemia	erythroleukemia	NN	NN	_	6	compound	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	K562	k562	NN	NN	_	9	nsubjpass	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	differentiate	differentiate	VB	VB	_	9	xcomp	_	_
12	along	along	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	megakaryocytic	megakaryocytic	JJ	JJ	_	14	conj	_	_
17	lineages	lineage	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	hexamethylene	hexamethylene	NN	NN	_	6	compound	_	_
6	bisacetamide	bisacetamide	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HMBA	hmba	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	induced	induce	VBD	VBD	_	3	ccomp	_	_
11	K562	k562	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	10	dobj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	differentiate	differentiate	VB	VB	_	10	xcomp	_	_
15	along	along	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	third	third	JJ	JJ	_	18	amod	_	_
18	pathway	pathway	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	accompanied	accompany	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	5	case	_	_
5	downregulation	downregulation	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	normally	normally	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	9	acl	_	_
12	in	in	IN	IN	_	18	case	_	_
13	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	mast	mast	NN	NN	_	13	conj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	megakaryocyte	megakaryocyte	NN	NN	_	13	conj	_	_
18	lineages	lineage	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	coordinate	coordinate	JJ	JJ	_	5	amod	_	_
5	downregulation	downregulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	globin	globin	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	gamma	gamma	NN	NN	_	11	compound	_	_
11	globin	globin	NN	NN	_	8	conj	_	_
12	in	in	IN	IN	_	8	cc	_	_
13	addition	addition	NN	NN	_	12	dep	_	_
14	to	to	TO	TO	_	12	dep	_	_
15	the	the	DT	DT	_	19	det	_	_
16	two	two	CD	CD	_	19	nummod	_	_
17	lineage-restricted	lineage-restricted	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	8	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	SCL	scl	NN	NN	_	19	appos	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	GATA-1	gata-1	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Proliferation	proliferation	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	K562	k562	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	suppressed	suppress	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Clonal	clonal	JJ	JJ	_	2	amod	_	_
2	assay	assay	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	suppression	suppression	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	irreversible	irreversible	JJ	JJ	_	3	ccomp	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	appeared	appear	VBD	VBD	_	8	conj	_	_
11	analogous	analogous	JJ	JJ	_	10	xcomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	commitment	commitment	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	murine	murine	JJ	JJ	_	17	amod	_	_
17	erythroleukemia	erythroleukemia	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	MEL	mel	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	terminal	terminal	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	MEL	mel	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	however	however	RB	RB	_	11	advmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	K562	k562	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	11	nsubj	_	_
11	acquired	acquire	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	macrophage-like	macrophage-like	JJ	JJ	_	14	amod	_	_
14	morphology	morphology	NN	NN	_	11	dobj	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	exhibited	exhibit	VBD	VBD	_	11	conj	_	_
17	a	a	DT	DT	_	19	det	_	_
18	complete	complete	JJ	JJ	_	19	amod	_	_
19	failure	failure	NN	NN	_	16	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	generate	generate	VB	VB	_	19	acl	_	_
22	benzidine-positive	benzidine-positive	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	21	dobj	_	_
24	.	.	.	.	_	11	punct	_	_

1	Electron	electron	NN	NN	_	2	compound	_	_
2	microscopy	microscopy	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	increase	increase	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	granules	granule	NNS	NNS	_	6	nmod	_	_
9	resembling	resemble	VBG	VBG	_	8	acl	_	_
10	those	those	DT	DT	_	9	xcomp	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	eosinophils	eosinophil	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Surface	surface	NN	NN	_	3	compound	_	_
2	marker	marker	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	HMBA-induced	hmba-induced	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	expressed	express	VBD	VBD	_	4	ccomp	_	_
9	reduced	reduce	VBN	VBN	_	10	amod	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glycophorin	glycophorin	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	CD5	cd5	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	CD7	cd7	NN	NN	_	13	conj	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	CD11b	cd11b	NN	NN	_	13	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	upregulation	upregulation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	megakaryocyte	megakaryocyte	NN	NN	_	7	amod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	lymphoid	lymphoid	JJ	JJ	_	4	conj	_	_
7	markers	marker	NNS	NNS	_	2	nmod	_	_
8	occurred	occur	VBD	VBD	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	response	response	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	K562	k562	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	HMBA	hmba	NN	NN	_	3	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	provide	provide	VB	VB	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	useful	useful	JJ	JJ	_	14	amod	_	_
13	experimental	experimental	JJ	JJ	_	14	amod	_	_
14	system	system	NN	NN	_	10	dobj	_	_
15	for	for	IN	IN	_	16	mark	_	_
16	studying	study	VBG	VBG	_	14	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	molecular	molecular	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	16	dobj	_	_
20	responsible	responsible	JJ	JJ	_	19	amod	_	_
21	for	for	IN	IN	_	22	case	_	_
22	downmodulation	downmodulation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	lineage-restricted	lineage-restricted	JJ	JJ	_	26	amod	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	22	nmod	_	_
27	during	during	IN	IN	_	30	case	_	_
28	hemopoietic	hemopoietic	JJ	JJ	_	30	amod	_	_
29	lineage	lineage	NN	NN	_	30	compound	_	_
30	commitment	commitment	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Sp1	sp1	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	binds	bind	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CD11b	cd11b	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	5	dobj	_	_
9	specifically	specifically	RB	RB	_	12	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	5	advmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	essential	essential	JJ	JJ	_	5	conj	_	_
18	for	for	IN	IN	_	21	case	_	_
19	myeloid-specific	myeloid-specific	JJ	JJ	_	21	amod	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	myeloid	myeloid	JJ	JJ	_	4	amod	_	_
3	integrin	integrin	NN	NN	_	4	compound	_	_
4	CD11b	cd11b	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	selectively	selectively	RB	RB	_	6	advmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	surface	surface	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	mature	mature	JJ	JJ	_	13	amod	_	_
13	macrophages	macrophage	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	monocytes	monocyte	NNS	NNS	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	neutrophils	neutrophil	NNS	NNS	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	natural	natural	JJ	JJ	_	22	amod	_	_
21	killer	killer	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	13	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Lineage-specific	lineage-specific	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	controlled	control	VBN	VBN	_	0	root	_	_
5	at	at	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	level	level	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	isolation	isolation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD11b	cd11b	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	shows	show	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	92	92	CD	CD	_	11	nummod	_	_
10	base	base	NN	NN	_	11	compound	_	_
11	pairs	pair	NNS	NNS	_	19	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	bp	bp	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	of	of	IN	IN	_	17	case	_	_
16	5'-flanking	5'-flanking	JJ	JJ	_	17	amod	_	_
17	DNA	dna	NN	NN	_	11	nmod	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	sufficient	sufficient	JJ	JJ	_	7	ccomp	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	direct	direct	VB	VB	_	19	xcomp	_	_
22	myeloid-specific	myeloid-specific	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	reporter	reporter	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	11	advcl	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	sequences	sequence	NNS	NNS	_	2	dobj	_	_
5	important	important	JJ	JJ	_	4	amod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	performed	perform	VBD	VBD	_	0	root	_	_
12	linker	linker	NN	NN	_	14	compound	_	_
13	scanning	scanning	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	92-bp	92-bp	JJ	JJ	_	19	amod	_	_
18	CD11b	cd11b	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	demonstrate	demonstrate	VB	VB	_	11	conj	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	a	a	DT	DT	_	24	det	_	_
24	sequence	sequence	NN	NN	_	29	nsubj	_	_
25	at	at	IN	IN	_	26	case	_	_
26	bp	bp	NN	NN	_	24	nmod	_	_
27	-60	-60	CD	CD	_	26	nummod	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	essential	essential	JJ	JJ	_	21	ccomp	_	_
30	for	for	IN	IN	_	33	case	_	_
31	CD11b	cd11b	NN	NN	_	33	compound	_	_
32	promoter	promoter	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	this	this	DT	DT	_	5	det	_	_
5	sequence	sequence	NN	NN	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	Sp1	sp1	NN	NN	_	6	dobj	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	13	advmod	_	_
13	and	and	CC	CC	_	6	advmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	7	advmod	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Sp1	sp1	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	bound	bind	VBN	VBN	_	0	root	_	_
8	only	only	RB	RB	_	14	advmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	U937	u937	NN	NN	_	10	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	cells	cell	NNS	NNS	_	7	advcl	_	_
15	,	,	,	,	_	14	punct	_	_
16	not	not	RB	RB	_	23	neg	_	_
17	in	in	IN	IN	_	23	case	_	_
18	cervical	cervical	JJ	JJ	_	19	amod	_	_
19	carcinoma	carcinoma	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	HeLa	hela	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	cells	cell	NNS	NNS	_	14	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	8	det	_	_
5	macrophage	macrophage	NN	NN	_	8	compound	_	_
6	transcription	transcription	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	PU.1	pu.1	NN	NN	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CD11b	cd11b	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	9	dobj	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	15	advmod	_	_
15	and	and	CC	CC	_	9	advmod	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vivo	vivo	FW	FW	_	15	advmod	_	_
18	close	close	RB	RB	_	9	advmod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	Sp1	sp1	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	15	nmod	_	_
7	binding	binding	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	myeloid-specific	myeloid-specific	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PU.1	pu.1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	allows	allow	VBZ	VBZ	_	4	acl:relcl	_	_
16	a	a	DT	DT	_	18	det	_	_
17	general	general	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	15	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Sp1	sp1	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	bind	bind	VB	VB	_	15	xcomp	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	tissue-specific	tissue-specific	JJ	JJ	_	27	amod	_	_
27	fashion	fashion	NN	NN	_	23	nmod	_	_
28	thereby	thereby	RB	RB	_	29	advmod	_	_
29	contributing	contribute	VBG	VBG	_	15	xcomp	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	myeloid-specific	myeloid-specific	JJ	JJ	_	33	amod	_	_
33	expression	expression	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	CD11b	cd11b	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Costimulation	costimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
4	blood	blood	NN	NN	_	7	compound	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Enhanced	enhance	VBD	VBD	_	3	amod	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	4	nsubj	_	_
4	correlates	correlate	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	increased	increase	VBN	VBN	_	8	amod	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	synthesis	synthesis	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	Fos	fos	NN	NN	_	12	compound	_	_
12	content	content	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	AP-1	ap-1	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Endothelial	endothelial	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EC	ec	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	act	act	VBP	VBP	_	0	root	_	_
7	as	as	IN	IN	_	8	case	_	_
8	APC	apc	NN	NN	_	6	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	resting	rest	VBG	VBG	_	11	amod	_	_
11	PBL	pbl	NN	NN	_	8	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	6	advmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	have	have	VB	VB	_	6	conj	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	roles	role	NNS	NNS	_	17	dobj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	17	advmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	pathogenesis	pathogenesis	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	allograft	allograft	NN	NN	_	27	compound	_	_
27	rejection	rejection	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	delayed	delay	VBN	VBN	_	30	amod	_	_
30	hypersensitivity	hypersensitivity	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	umbilical	umbilical	JJ	JJ	_	8	amod	_	_
7	vein	vein	NN	NN	_	8	compound	_	_
8	EC	ec	NN	NN	_	9	nsubj	_	_
9	provide	provide	VBP	VBP	_	3	ccomp	_	_
10	costimulatory	costimulatory	JJ	JJ	_	11	amod	_	_
11	signals	signal	NNS	NNS	_	9	dobj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	PHA-stimulated	pha-stimulated	JJ	JJ	_	14	amod	_	_
14	PBL	pbl	NN	NN	_	9	nmod	_	_
15	via	via	IN	IN	_	18	case	_	_
16	CD2:lymphocyte	cd2:lymphocyte	NN	NN	_	17	nmod:npmod	_	_
17	function-associated	function-associated	JJ	JJ	_	18	amod	_	_
18	Ag-3	ag-3	NN	NN	_	9	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	an	a	DT	DT	_	23	det	_	_
21	unidentified	unidentified	JJ	JJ	_	23	amod	_	_
22	ligand	ligand	NN	NN	_	23	compound	_	_
23	pair	pair	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	9	punct	_	_
25	resulting	result	VBG	VBG	_	9	advcl	_	_
26	in	in	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	three-	three-	CD	CD	_	31	nummod	_	_
29	to	to	TO	TO	_	28	dep	_	_
30	eight-fold	eight-fold	JJ	JJ	_	28	advmod	_	_
31	enhancement	enhancement	NN	NN	_	25	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	IL-2	il-2	NN	NN	_	34	compound	_	_
34	production	production	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	physiologic	physiologic	JJ	JJ	_	3	amod	_	_
3	relevance	relevance	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	increase	increase	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	proliferative	proliferative	JJ	JJ	_	12	amod	_	_
12	advantage	advantage	NN	NN	_	8	nmod	_	_
13	provided	provide	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	EC	ec	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	PBL	pbl	NN	NN	_	13	nmod	_	_
18	suboptimally	suboptimally	RB	RB	_	19	advmod	_	_
19	stimulated	stimulate	VBN	VBN	_	17	acl	_	_
20	with	with	IN	IN	_	22	case	_	_
21	mAb	mab	NN	NN	_	22	compound	_	_
22	OKT3	okt3	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	EC	ec	NN	NN	_	6	compound	_	_
6	costimulation	costimulation	NN	NN	_	7	nsubj	_	_
7	causes	cause	VBZ	VBZ	_	3	ccomp	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	result	result	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	increased	increase	VBN	VBN	_	19	amod	_	_
18	IL-2	il-2	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	PBL	pbl	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	EC	ec	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	12	case	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	5	nmod	_	_
13	known	know	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	regulate	regulate	VB	VB	_	13	xcomp	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	12	punct	_	_
19	including	include	VBG	VBG	_	23	case	_	_
20	c-jun	c-jun	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	c-fos-two	c-fos-two	NN	NN	_	20	conj	_	_
23	components	component	NNS	NNS	_	12	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	AP-1	ap-1	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	NFAT	nfat	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	others	other	NNS	NNS	_	28	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	PBL	pbl	NN	NN	_	3	nsubj	_	_
2	constitutively	constitutively	RB	RB	_	3	advmod	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	c-jun	c-jun	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	the	the	DT	DT	_	9	det	_	_
9	level	level	NN	NN	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	c-jun	c-jun	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	altered	alter	VBN	VBN	_	3	conj	_	_
16	by	by	IN	IN	_	18	case	_	_
17	PHA	pha	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	absence	absence	NN	NN	_	15	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	presence	presence	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	EC	ec	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	c-fos	c-fos	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	absent	absent	JJ	JJ	_	0	root	_	_
8	from	from	IN	IN	_	11	case	_	_
9	resting	rest	VBG	VBG	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	7	conj	_	_
15	on	on	IN	IN	_	17	case	_	_
16	PHA	pha	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	EC	ec	NN	NN	_	5	nsubj	_	_
2	alone	alone	RB	RB	_	1	advmod	_	_
3	do	do	VBP	VBP	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	induce	induce	VB	VB	_	0	root	_	_
6	c-fos	c-fos	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	5	dobj	_	_
8	but	but	CC	CC	_	5	cc	_	_
9	augment	augment	VBP	VBP	_	5	conj	_	_
10	the	the	DT	DT	_	11	det	_	_
11	level	level	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	c-fos	c-fos	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	PHA-activated	pha-activated	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	3-	3-	CD	CD	_	9	nmod	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	10-fold	10-fold	RB	RB	_	20	advmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	largely	largely	RB	RB	_	5	advmod	_	_
5	independent	independent	JJ	JJ	_	0	root	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	CD2:lymphocyte	cd2:lymphocyte	NN	NN	_	9	nmod:npmod	_	_
9	function-associated	function-associated	JJ	JJ	_	11	amod	_	_
10	Ag-3	ag-3	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Gel-shift	gel-shift	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	reveals	reveal	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	presence	presence	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	resting	rest	VBG	VBG	_	12	amod	_	_
12	PBL	pbl	NN	NN	_	6	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	bind	bind	VBP	VBP	_	6	acl:relcl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	proximal	proximal	JJ	JJ	_	19	amod	_	_
18	AP-1	ap-1	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	that	that	IN	IN	_	26	nsubj	_	_
26	contain	contain	VBP	VBP	_	14	conj	_	_
27	immunoreactive	immunoreactive	JJ	JJ	_	32	amod	_	_
28	c-Jun	c-jun	NN	NN	_	32	compound	_	_
29	but	but	CC	CC	_	30	cc	_	_
30	not	not	RB	RB	_	28	cc	_	_
31	c-Fos	c-fos	NN	NN	_	28	conj	_	_
32	protein	protein	NN	NN	_	26	dobj	_	_
33	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	AP-1	ap-1	NN	NN	_	8	nsubj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	PHA-activated	pha-activated	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	contains	contain	VBZ	VBZ	_	0	root	_	_
9	c-Jun	c-jun	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	9	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	c-Fos	c-fos	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Strikingly	strikingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	costimulation	costimulation	NN	NN	_	6	nsubj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	EC	ec	NN	NN	_	3	nmod	_	_
6	results	result	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dramatic	dramatic	JJ	JJ	_	10	amod	_	_
10	increase	increase	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	up	up	NN	NN	_	10	dep	_	_
13	to	to	TO	TO	_	12	dep	_	_
14	15-fold	15-fold	JJ	JJ	_	12	advmod	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	c-Fos	c-fos	NN	NN	_	19	compound	_	_
19	content	content	NN	NN	_	10	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	AP-1	ap-1	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Levels	level	NNS	NNS	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	other	other	JJ	JJ	_	5	amod	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	1	nmod	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	altered	alter	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	EC	ec	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	although	although	IN	IN	_	19	mark	_	_
17	NFAT-DNA	nfat-dna	NN	NN	_	18	compound	_	_
18	complexes	complex	NNS	NNS	_	19	nsubj	_	_
19	migrated	migrate	VBD	VBD	_	12	advcl	_	_
20	at	at	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	slightly	slightly	RB	RB	_	23	advmod	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	mobility	mobility	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	changes	change	NNS	NNS	_	20	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	composition	composition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	AP-1	ap-1	NN	NN	_	11	nmod	_	_
16	is	be	VBZ	VBZ	_	20	cop	_	_
17	a	a	DT	DT	_	20	det	_	_
18	key	key	JJ	JJ	_	20	amod	_	_
19	molecular	molecular	JJ	JJ	_	20	amod	_	_
20	mechanism	mechanism	NN	NN	_	6	ccomp	_	_
21	for	for	IN	IN	_	24	case	_	_
22	increasing	increase	VBG	VBG	_	24	amod	_	_
23	IL-2	il-2	NN	NN	_	24	compound	_	_
24	transcription	transcription	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	underlie	underlie	VB	VB	_	20	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	phenomenon	phenomenon	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	costimulation	costimulation	NN	NN	_	29	nmod	_	_
32	by	by	IN	IN	_	33	case	_	_
33	EC	ec	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	AP-1	ap-1	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	component	component	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NF-AT	nf-at	NN	NN	_	2	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activator	activator	NN	NN	_	0	root	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	IL-2	il-2	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	response	response	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	8	nsubj	_	_
4	for	for	IN	IN	_	5	case	_	_
5	NF-AT	nf-at	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	a	a	DT	DT	_	8	det	_	_
8	sequence	sequence	NN	NN	_	0	root	_	_
9	localized	localized	JJ	JJ	_	8	dep	_	_
10	between	between	IN	IN	_	11	case	_	_
11	-285/-254	-285/-254	CD	CD	_	9	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	IL-2	il-2	NN	NN	_	16	compound	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	composition	composition	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-AT	nf-at	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	10	auxpass	_	_
7	still	still	RB	RB	_	10	advmod	_	_
8	not	not	RB	RB	_	9	dep	_	_
9	fully	fully	RB	RB	_	10	advmod	_	_
10	elucidated	elucidate	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	,	,	,	,	_	16	punct	_	_
5	in	in	IN	IN	_	9	case	_	_
6	normal	normal	JJ	JJ	_	9	amod	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	16	nmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	an	a	DT	DT	_	13	det	_	_
12	AP-1	ap-1	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	component	component	NN	NN	_	2	ccomp	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	NF-AT	nf-at	NN	NN	_	21	compound	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	complex	complex	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	evidenced	evidence	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ability	ability	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	6	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	compete	compete	VB	VB	_	6	acl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	NF-AT	nf-at	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	for	for	IN	IN	_	18	case	_	_
18	binding	binding	NN	NN	_	12	advcl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	NF-AT	nf-at	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	6	cc	_	_
22	by	by	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	capacity	capacity	NN	NN	_	6	conj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	immobilized	immobilize	VBN	VBN	_	30	amod	_	_
27	anti-Jun	anti-jun	JJ	JJ	_	30	amod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	anti-Fos	anti-fos	JJ	JJ	_	27	conj	_	_
30	antibodies	antibody	NNS	NNS	_	24	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	deplete	deplete	VB	VB	_	24	acl	_	_
33	NF-AT-binding	nf-at-binding	NN	NN	_	34	compound	_	_
34	activity	activity	NN	NN	_	32	dobj	_	_
35	from	from	IN	IN	_	37	case	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	extracts	extract	NNS	NNS	_	32	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	activated	activate	VBN	VBN	_	41	amod	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	37	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	detectable	detectable	JJ	JJ	_	5	amod	_	_
5	binding	binding	NN	NN	_	2	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	9	advmod	_	_
9	translated	translate	VBN	VBN	_	11	amod	_	_
10	Jun/Fos	jun/fos	NN	NN	_	11	compound	_	_
11	heterodimer	heterodimer	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AP-1	ap-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	NF-AT	nf-at	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	5	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	and	and	CC	CC	_	2	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	NF-AT	nf-at	NN	NN	_	23	compound	_	_
23	sequence	sequence	NN	NN	_	25	nsubj	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	unable	unable	JJ	JJ	_	2	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	inhibit	inhibit	VB	VB	_	25	xcomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	binding	binding	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	Jun/Fos	jun/fos	NN	NN	_	29	nmod	_	_
32	to	to	TO	TO	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	AP-1	ap-1	NN	NN	_	35	compound	_	_
35	sequence	sequence	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	AP-1	ap-1	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-AT	nf-at	NN	NN	_	11	compound	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	complex	complex	NN	NN	_	2	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	regulate	regulate	VB	VB	_	0	root	_	_
14	NF-AT-binding	nf-at-binding	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	through	through	IN	IN	_	18	case	_	_
17	protein-protein	protein-protein	JJ	JJ	_	18	amod	_	_
18	interaction	interaction	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	antagonism	antagonism	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	5	case	_	_
4	vitamin	vitamin	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	regulation	regulation	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	CD14	cd14	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	CD23	cd23	NN	NN	_	13	conj	_	_
16	expression	expression	NN	NN	_	11	nmod	_	_
17	during	during	IN	IN	_	19	case	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	11	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	U-937	u-937	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	1,25	1,25	CD	CD	_	2	nummod	_	_
2	alpha-Dihydroxicholecalciferol	alpha-dihydroxicholecalciferol	NN	NN	_	14	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	VitD3	vitd3	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	2	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	RA	ra	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	important	important	JJ	JJ	_	14	amod	_	_
14	regulators	regulator	NNS	NNS	_	0	root	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	proliferation	proliferation	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	differentiation	differentiation	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	several	several	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	types	type	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	describes	describe	VBZ	VBZ	_	0	root	_	_
4	how	how	WRB	WRB	_	27	advmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	27	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	10	amod	_	_
10	Ag	ag	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	CD14	cd14	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	the	the	DT	DT	_	19	det	_	_
16	low	low	JJ	JJ	_	19	amod	_	_
17	affinity	affinity	NN	NN	_	19	compound	_	_
18	Fc	fc	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	6	conj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	IgE	ige	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	19	punct	_	_
23	CD23	cd23	NN	NN	_	19	appos	_	_
24	,	,	,	,	_	19	punct	_	_
25	were	be	VBD	VBD	_	27	auxpass	_	_
26	inversely	inversely	RB	RB	_	27	advmod	_	_
27	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
28	during	during	IN	IN	_	33	case	_	_
29	VitD3-	vitd3-	NN	NN	_	33	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	RA-induced	ra-induced	JJ	JJ	_	29	conj	_	_
32	monocytic	monocytic	JJ	JJ	_	33	amod	_	_
33	differentiation	differentiation	NN	NN	_	27	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	human	human	JJ	JJ	_	37	amod	_	_
36	U-937	u-937	NN	NN	_	37	compound	_	_
37	monoblasts	monoblast	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	PMA	pma	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	CD14	cd14	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CD23	cd23	NN	NN	_	7	conj	_	_
10	mRNA	mrna	NN	NN	_	7	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	10	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	Exposure	exposure	NN	NN	_	5	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	VitD3	vitd3	NN	NN	_	1	nmod	_	_
4	rapidly	rapidly	RB	RB	_	5	advmod	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	de	de	FW	FW	_	9	amod	_	_
8	novo	novo	FW	FW	_	7	dep	_	_
9	expression	expression	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD14	cd14	NN	NN	_	9	nmod	_	_
12	mRNA	mrna	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	protein	protein	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	cycloheximide	cycloheximide	NN	NN	_	2	nmod	_	_
5	completely	completely	RB	RB	_	6	advmod	_	_
6	blocked	block	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	VitD3	vitd3	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	CD14	cd14	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	indicating	indicate	VBG	VBG	_	6	advcl	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	induction	induction	NN	NN	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	dependent	dependent	JJ	JJ	_	15	ccomp	_	_
21	on	on	IN	IN	_	24	case	_	_
22	ongoing	ongoing	JJ	JJ	_	24	amod	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	synthesis	synthesis	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	While	while	IN	IN	_	2	mark	_	_
2	inducing	induce	VBG	VBG	_	8	advcl	_	_
3	CD14	cd14	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	8	punct	_	_
6	VitD3	vitd3	NN	NN	_	8	nsubj	_	_
7	concomitantly	concomitantly	RB	RB	_	8	advmod	_	_
8	suppressed	suppress	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	17	det	_	_
10	basal	basal	JJ	JJ	_	17	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	PMA-	pma-	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	RA-inducible	ra-inducible	JJ	JJ	_	10	conj	_	_
16	CD23	cd23	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	8	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	dose-dependent	dose-dependent	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	8	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	U-937	u-937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	10	nsubj	_	_
6	induced	induce	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	RA	ra	NN	NN	_	6	nmod	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CD23	cd23	NN	NN	_	12	nmod	_	_
15	mRNA	mrna	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	protein	protein	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	whereas	whereas	IN	IN	_	10	dep	_	_
20	they	they	PRP	PRP	_	22	nsubj	_	_
21	completely	completely	RB	RB	_	22	advmod	_	_
22	lacked	lack	VBD	VBD	_	10	parataxis	_	_
23	detectable	detectable	JJ	JJ	_	29	amod	_	_
24	CD14	cd14	NN	NN	_	29	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	surface	surface	NN	NN	_	29	compound	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	mRNA	mrna	NN	NN	_	26	conj	_	_
29	expression	expression	NN	NN	_	22	dobj	_	_
30	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	VitD3-	vitd3-	NN	NN	_	11	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	PMA-induced	pma-induced	JJ	JJ	_	4	conj	_	_
8	CD14	cd14	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	dep	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	temporal	temporal	JJ	JJ	_	15	amod	_	_
15	consequence	consequence	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	RA-induced	ra-induced	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	exists	exist	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	antagonism	antagonism	NN	NN	_	6	dobj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	VitD3	vitd3	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	RA	ra	NN	NN	_	11	conj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	have	have	VB	VB	_	9	acl:relcl	_	_
17	important	important	JJ	JJ	_	18	amod	_	_
18	implications	implication	NNS	NNS	_	16	dobj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	regulation	regulation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	certain	certain	JJ	JJ	_	27	amod	_	_
24	immune	immune	JJ	JJ	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	inflammatory	inflammatory	JJ	JJ	_	24	conj	_	_
27	responses	response	NNS	NNS	_	21	nmod	_	_
28	through	through	IN	IN	_	31	case	_	_
29	their	they	PRP$	PRP$	_	31	nmod:poss	_	_
30	inverse	inverse	JJ	JJ	_	31	amod	_	_
31	effects	effect	NNS	NNS	_	16	nmod	_	_
32	on	on	IN	IN	_	37	case	_	_
33	CD14	cd14	NN	NN	_	37	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	CD23	cd23	NN	NN	_	33	conj	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	lytic	lytic	JJ	JJ	_	3	amod	_	_
3	transition	transition	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
6	virus	virus	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	imitated	imitate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	recombinant	recombinant	JJ	JJ	_	11	amod	_	_
11	B-cells	b-cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	Lytic	lytic	JJ	JJ	_	2	amod	_	_
2	transition	transition	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
5	virus	virus	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EBV	ebv	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	initiated	initiate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	15	case	_	_
12	distinct	distinct	JJ	JJ	_	15	amod	_	_
13	immediate	immediate	JJ	JJ	_	15	amod	_	_
14	early	early	JJ	JJ	_	15	amod	_	_
15	regulators	regulator	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	cycle	cycle	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	synchronization	synchronization	NN	NN	_	10	nmod	_	_
23	to	to	TO	TO	_	27	case	_	_
24	temporary	temporary	JJ	JJ	_	27	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	permissive	permissive	JJ	JJ	_	24	dep	_	_
27	conditions	condition	NNS	NNS	_	22	nmod	_	_
28	during	during	IN	IN	_	31	case	_	_
29	host	host	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	differentiation	differentiation	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	developed	develop	VBD	VBD	_	0	root	_	_
3	eukaryotic	eukaryotic	JJ	JJ	_	4	amod	_	_
4	vectors	vector	NNS	NNS	_	2	dobj	_	_
5	suitable	suitable	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	imitate	imitate	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	processes	process	NNS	NNS	_	7	dobj	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	lytic	lytic	JJ	JJ	_	13	amod	_	_
13	transition	transition	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	culture	culture	NN	NN	_	17	compound	_	_
17	systems	system	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	stable	stable	JJ	JJ	_	5	amod	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	established	establish	VBN	VBN	_	0	root	_	_
8	:	:	:	:	_	7	punct	_	_
9	R59Z	r59z	NN	NN	_	11	compound	_	_
10	activator	activator	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	13	nsubjpass	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	used	use	VBN	VBN	_	7	parataxis	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	induce	induce	VB	VB	_	13	xcomp	_	_
16	lytic	lytic	JJ	JJ	_	18	amod	_	_
17	EBV	ebv	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	constitutive	constitutive	JJ	JJ	_	22	amod	_	_
22	manner	manner	NN	NN	_	15	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	production	production	NN	NN	_	15	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	BZLF	bzlf	NN	NN	_	30	compound	_	_
29	1	1	CD	CD	_	30	nummod	_	_
30	trans-activator	trans-activator	NN	NN	_	25	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	Zta	zta	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	13	punct	_	_

1	R7-57	r7-57	NN	NN	_	3	compound	_	_
2	reporter	reporter	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nsubj	_	_
4	,	,	,	,	_	10	punct	_	_
5	on	on	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	hand	hand	NN	NN	_	10	nmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	signaled	signal	VBD	VBD	_	0	root	_	_
11	induced	induce	VBN	VBN	_	12	amod	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	lytic	lytic	JJ	JJ	_	16	amod	_	_
16	origin	origin	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	EBV	ebv	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	ori	ori	NN	NN	_	22	compound	_	_
22	Lyt	lyt	NN	NN	_	16	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	10	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	modes	mode	NNS	NNS	_	16	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	like	like	IN	IN	_	6	case	_	_
5	chemical	chemical	JJ	JJ	_	6	amod	_	_
6	induction	induction	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	lytic	lytic	JJ	JJ	_	9	amod	_	_
9	superinfection	superinfection	NN	NN	_	6	conj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	EBV	ebv	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	single	single	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	trans-activation	trans-activation	NN	NN	_	6	conj	_	_
16	converted	convert	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	21	det	_	_
18	recombinant	recombinant	JJ	JJ	_	21	amod	_	_
19	ori	ori	NN	NN	_	21	compound	_	_
20	Lyt	lyt	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	16	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	R7-57	r7-57	NN	NN	_	25	compound	_	_
24	reporter	reporter	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	BZLF	bzlf	NN	NN	_	15	nsubj	_	_
2	1	1	CD	CD	_	1	nummod	_	_
3	,	,	,	,	_	1	punct	_	_
4	transiently	transiently	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	1	acl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	R7-57	r7-57	NN	NN	_	9	compound	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	was	be	VBD	VBD	_	15	cop	_	_
12	the	the	DT	DT	_	15	det	_	_
13	only	only	JJ	JJ	_	15	amod	_	_
14	EBV	ebv	NN	NN	_	15	compound	_	_
15	trans-activator	trans-activator	NN	NN	_	0	root	_	_
16	found	find	VBN	VBN	_	15	acl	_	_
17	,	,	,	,	_	15	punct	_	_
18	sufficient	sufficient	JJ	JJ	_	15	amod	_	_
19	in	in	NN	NN	_	20	dep	_	_
20	inducing	induce	VBG	VBG	_	18	advcl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	viral	viral	JJ	JJ	_	24	amod	_	_
23	lytic	lytic	JJ	JJ	_	24	amod	_	_
24	cycle	cycle	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	15	punct	_	_

1	Basing	base	VBG	VBG	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	experiments	experiment	NNS	NNS	_	11	advcl	_	_
5	,	,	,	,	_	11	punct	_	_
6	trans-cellular	trans-cellular	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	11	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	EBV	ebv	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	tested	test	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	cocultivation	cocultivation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	BZLF	bzlf	NN	NN	_	16	nmod:npmod	_	_
16	1-expressing	1-expressing	JJ	JJ	_	19	amod	_	_
17	R59Z	r59z	NN	NN	_	19	compound	_	_
18	activator	activator	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	R7-57	r7-57	NN	NN	_	24	compound	_	_
23	reporter	reporter	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	13	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	lytic	lytic	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	10	nsubjpass	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	reporter	reporter	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	measured	measure	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	neither	neither	CC	CC	_	14	cc:preconj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	cocultivation	cocultivation	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	activator	activator	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	nor	nor	CC	CC	_	14	cc	_	_
19	by	by	IN	IN	_	20	case	_	_
20	coincubation	coincubation	NN	NN	_	14	conj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	BZLF	bzlf	NN	NN	_	23	nmod:npmod	_	_
23	1-containing	1-containing	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lysates	lysate	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Latency	latency	NN	NN	_	3	compound	_	_
2	breaking	breaking	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	,	,	,	,	_	8	punct	_	_
5	however	however	RB	RB	_	8	advmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	transferred	transfer	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	10	case	_	_
10	activator	activator	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	when	when	WRB	WRB	_	20	advmod	_	_
15	active	active	JJ	JJ	_	18	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	exogenous	exogenous	JJ	JJ	_	15	dep	_	_
18	virus	virus	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	added	add	VBN	VBN	_	8	advcl	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	system	system	NN	NN	_	8	nsubj	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	experiments	experiment	NNS	NNS	_	4	nmod	_	_
8	provides	provide	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	tool	tool	NN	NN	_	8	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	detection	detection	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	EBV	ebv	NN	NN	_	16	compound	_	_
16	reactivation	reactivation	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	demonstrates	demonstrate	VBZ	VBZ	_	8	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	potential	potential	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	lytic	lytic	JJ	JJ	_	26	amod	_	_
24	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	BZLF	bzlf	NN	NN	_	20	nmod	_	_
27	1	1	CD	CD	_	26	nummod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Immobilization	immobilization	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	recovery	recovery	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	fusion	fusion	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	B-lymphocyte	b-lymphocyte	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	conj	_	_
10	using	use	VBG	VBG	_	1	acl	_	_
11	magnetic	magnetic	JJ	JJ	_	12	amod	_	_
12	separation	separation	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	approach	approach	NN	NN	_	20	nsubjpass	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	facilitate	facilitate	VB	VB	_	3	acl	_	_
6	immobilization	immobilization	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	affinity	affinity	NN	NN	_	9	compound	_	_
9	purification	purification	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	recombinant	recombinant	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	selected	select	VBN	VBN	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	12	conj	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	developed	develop	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Using	use	VBG	VBG	_	23	advcl	_	_
2	magnetic	magnetic	JJ	JJ	_	3	amod	_	_
3	beads	bead	NNS	NNS	_	1	dobj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	attached	attach	VBN	VBN	_	6	amod	_	_
6	DNA	dna	NN	NN	_	3	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	12	det	_	_
9	Escherichia	escherichia	FW	FW	_	12	compound	_	_
10	coli	coli	FW	FW	_	12	compound	_	_
11	lac	lac	NN	NN	_	12	compound	_	_
12	operator	operator	NN	NN	_	7	dobj	_	_
13	,	,	,	,	_	23	punct	_	_
14	fusion	fusion	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	23	nsubj	_	_
16	comprising	comprise	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
19	lac	lac	NN	NN	_	20	compound	_	_
20	repressor	repressor	NN	NN	_	16	dobj	_	_
21	could	could	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	aux	_	_
23	affinity-purified	affinity-purified	JJ	JJ	_	0	root	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	recovered	recover	VBN	VBN	_	23	conj	_	_
26	by	by	IN	IN	_	29	case	_	_
27	gentle	gentle	JJ	JJ	_	29	amod	_	_
28	elution	elution	NN	NN	_	29	compound	_	_
29	conditions	condition	NNS	NNS	_	23	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	such	such	JJ	JJ	_	36	case	_	_
32	as	as	IN	IN	_	31	mwe	_	_
33	with	with	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	lactose	lactose	NN	NN	_	36	compound	_	_
36	analogue	analogue	NN	NN	_	29	acl	_	_
37	or	or	CC	CC	_	29	cc	_	_
38	by	by	IN	IN	_	40	case	_	_
39	enzymatic	enzymatic	JJ	JJ	_	40	amod	_	_
40	means	means	NNS	NNS	_	29	conj	_	_
41	using	use	VBG	VBG	_	40	acl	_	_
42	either	either	CC	CC	_	43	cc:preconj	_	_
43	deoxyribonuclease	deoxyribonuclease	NN	NN	_	41	dobj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	DNase	dnase	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	or	or	CC	CC	_	43	cc	_	_
48	restriction	restriction	NN	NN	_	49	compound	_	_
49	endonucleases	endonuclease	NNS	NNS	_	43	conj	_	_
50	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	a	a	DT	DT	_	11	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	14	nsubjpass	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	3	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	affinity	affinity	NN	NN	_	17	compound	_	_
17	purification	purification	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	fusion	fusion	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	exemplified	exemplify	VBN	VBN	_	14	advcl	_	_
23	by	by	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	specific	specific	JJ	JJ	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	gentle	gentle	JJ	JJ	_	25	conj	_	_
28	recovery	recovery	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	beta-galactosidase	beta-galactosidase	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	alkaline	alkaline	NN	NN	_	33	compound	_	_
33	phosphatase	phosphatase	NN	NN	_	30	conj	_	_
34	from	from	IN	IN	_	36	case	_	_
35	bacterial	bacterial	JJ	JJ	_	36	amod	_	_
36	lysates	lysate	NNS	NNS	_	28	nmod	_	_
37	using	use	VBG	VBG	_	22	xcomp	_	_
38	immunomagnetic	immunomagnetic	JJ	JJ	_	39	amod	_	_
39	separation	separation	NN	NN	_	37	dobj	_	_
40	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	approach	approach	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	extended	extend	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	separation	separation	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	efficient	efficient	JJ	JJ	_	12	amod	_	_
12	recovery	recovery	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	elution	elution	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	CD37	cd37	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
20	from	from	IN	IN	_	22	case	_	_
21	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
22	blood	blood	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Negative	negative	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	11	case	_	_
5	human	human	JJ	JJ	_	11	amod	_	_
6	interleukin	interleukin	NN	NN	_	11	compound	_	_
7	2	2	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IL-2	il-2	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	3	nmod	_	_
14	through	through	IN	IN	_	15	case	_	_
15	interference	interference	NN	NN	_	3	nmod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	AP-1	ap-1	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NF-AT	nf-at	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	IL-2	il-2	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	affected	affect	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	several	several	JJ	JJ	_	9	amod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	asked	ask	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	14	mark	_	_
4	dexamethasone	dexamethasone	NN	NN	_	14	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Dex	dex	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	4	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CsA	csa	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	inhibit	inhibit	VBP	VBP	_	2	ccomp	_	_
15	IL-2	il-2	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	14	dobj	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	interfering	interfere	VBG	VBG	_	14	advcl	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	bind	bind	VBP	VBP	_	25	acl:relcl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	IL-2	il-2	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	extracts	extract	NNS	NNS	_	9	nsubjpass	_	_
3	from	from	IN	IN	_	7	case	_	_
4	primary	primary	JJ	JJ	_	7	case	_	_
5	human	human	JJ	JJ	_	7	case	_	_
6	T	t	NN	NN	_	7	dep	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	acl	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	analyzed	analyze	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	15	case	_	_
11	electrophoretic	electrophoretic	JJ	JJ	_	15	amod	_	_
12	DNA	dna	NN	NN	_	15	compound	_	_
13	mobility	mobility	NN	NN	_	15	compound	_	_
14	shift	shift	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	Dex	dex	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CsA	csa	NN	NN	_	2	conj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	AP-1	ap-1	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NF-AT	nf-at	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	but	but	CC	CC	_	10	cc	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NF-kB	nf-kb	NN	NN	_	10	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	OCT-1/OAF	oct-1/oaf	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	7	punct	_	_
22	to	to	TO	TO	_	25	case	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	corresponding	corresponding	JJ	JJ	_	25	amod	_	_
25	sites	site	NNS	NNS	_	7	nmod	_	_
26	on	on	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	IL-2	il-2	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	correlate	correlate	VB	VB	_	26	advcl	_	_
3	changes	change	NNS	NNS	_	2	dobj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	3	nmod	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	3	advmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	2	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	12	advmod	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	define	define	VB	VB	_	2	conj	_	_
17	the	the	DT	DT	_	19	det	_	_
18	structural	structural	JJ	JJ	_	19	amod	_	_
19	requirements	requirement	NNS	NNS	_	16	dobj	_	_
20	for	for	IN	IN	_	23	case	_	_
21	IL-2	il-2	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	repression	repression	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	used	use	VBD	VBD	_	0	root	_	_
27	transient	transient	JJ	JJ	_	29	amod	_	_
28	DNA	dna	NN	NN	_	29	compound	_	_
29	transfections	transfection	NNS	NNS	_	26	dobj	_	_
30	.	.	.	.	_	26	punct	_	_

1	Jurkat	jurkat	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	transfected	transfect	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	plasmids	plasmid	NNS	NNS	_	4	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	either	either	CC	CC	_	12	cc:preconj	_	_
9	the	the	DT	DT	_	12	det	_	_
10	intact	intact	JJ	JJ	_	12	amod	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	7	dobj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
15	AP-1	ap-1	NN	NN	_	21	compound	_	_
16	,	,	,	,	_	15	punct	_	_
17	NF-AT	nf-at	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	NF-kB	nf-kb	NN	NN	_	15	conj	_	_
21	motifs	motif	NNS	NNS	_	12	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Dex	dex	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	8	det	_	_
8	AP-1	ap-1	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	5	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	NF-AT	nf-at	NN	NN	_	5	conj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-kB	nf-kb	NN	NN	_	13	conj	_	_
16	plasmids	plasmid	NNS	NNS	_	5	dep	_	_
17	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	CsA	csa	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	NF-AT	nf-at	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	8	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	AP-1	ap-1	NN	NN	_	8	conj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kB	nf-kb	NN	NN	_	16	conj	_	_
19	plasmids	plasmid	NNS	NNS	_	8	dep	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	Dex	dex	NN	NN	_	13	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CsA	csa	NN	NN	_	10	conj	_	_
13	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
14	IL-2	il-2	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	13	dobj	_	_
17	through	through	IN	IN	_	18	case	_	_
18	interference	interference	NN	NN	_	13	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	nmod	_	_
22	AP-1	ap-1	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NF-AT	nf-at	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	,	,	,	,	_	20	punct	_	_
5	while	while	IN	IN	_	9	mark	_	_
6	maximum	maximum	NN	NN	_	7	compound	_	_
7	inhibition	inhibition	NN	NN	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	involve	involve	VB	VB	_	20	advcl	_	_
10	interaction	interaction	NN	NN	_	9	dobj	_	_
11	with	with	IN	IN	_	14	case	_	_
12	both	both	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	20	punct	_	_
16	AP-1	ap-1	NN	NN	_	20	nsubj	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	the	the	DT	DT	_	20	det	_	_
19	primary	primary	JJ	JJ	_	20	amod	_	_
20	target	target	NN	NN	_	2	ccomp	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Dex	dex	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	7	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	disease	disease	NN	NN	_	4	nmod	_	_
7	suggest	suggest	VBP	VBP	_	0	root	_	_
8	adenovirus	adenovirus	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	one	one	CD	CD	_	11	nummod	_	_
11	cause	cause	NN	NN	_	7	ccomp	_	_
12	of	of	IN	IN	_	17	case	_	_
13	persistent	persistent	JJ	JJ	_	17	amod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	recurrent	recurrent	JJ	JJ	_	13	conj	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	arthritis	arthritis	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	assessment	assessment	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	synovial	synovial	JJ	JJ	_	6	amod	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	reactivity	reactivity	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	adenovirus	adenovirus	NN	NN	_	10	compound	_	_
9	antigen	antigen	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	undertaken	undertake	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	20	case	_	_
16	persistent	persistent	JJ	JJ	_	20	amod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	recurrent	recurrent	JJ	JJ	_	16	conj	_	_
19	inflammatory	inflammatory	JJ	JJ	_	20	amod	_	_
20	arthritis	arthritis	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	3H-thymidine	3h-thymidine	JJ	JJ	_	4	amod	_	_
3	uptake	uptake	NN	NN	_	4	compound	_	_
4	procedure	procedure	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	employed	employ	VBN	VBN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	incorporating	incorporate	VBG	VBG	_	6	xcomp	_	_
9	multiple	multiple	JJ	JJ	_	11	amod	_	_
10	microbiological	microbiological	JJ	JJ	_	11	amod	_	_
11	antigens	antigen	NNS	NNS	_	8	dobj	_	_
12	.	.	.	.	_	6	punct	_	_

1	Five	five	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	repeated	repeat	VBN	VBN	_	8	amod	_	_
7	maximal	maximal	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	4	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	adenovirus	adenovirus	NN	NN	_	11	compound	_	_
11	antigen	antigen	NN	NN	_	8	nmod	_	_
12	;	;	:	:	_	4	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	one	one	CD	CD	_	21	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	these	these	DT	DT	_	14	nmod	_	_
17	adenovirus	adenovirus	NN	NN	_	19	compound	_	_
18	nucleotide	nucleotide	NN	NN	_	19	compound	_	_
19	sequences	sequence	NNS	NNS	_	21	nsubj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	present	present	JJ	JJ	_	4	parataxis	_	_
22	in	in	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	synovial	synovial	JJ	JJ	_	26	amod	_	_
25	biopsy	biopsy	NN	NN	_	26	compound	_	_
26	specimen	specimen	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	adenovirus	adenovirus	NN	NN	_	9	nsubj	_	_
6	may	may	MD	MD	_	9	aux	_	_
7	be	be	VB	VB	_	9	cop	_	_
8	one	one	CD	CD	_	9	nummod	_	_
9	cause	cause	NN	NN	_	3	ccomp	_	_
10	of	of	IN	IN	_	15	case	_	_
11	persistent	persistent	JJ	JJ	_	15	amod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	recurrent	recurrent	JJ	JJ	_	11	conj	_	_
14	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
15	arthritis	arthritis	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	CD3-CD16+	cd3-cd16+	JJ	JJ	_	5	amod	_	_
3	natural	natural	JJ	JJ	_	5	amod	_	_
4	killer	killer	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	express	express	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	12	det	_	_
8	hGATA-3	hgata-3	NN	NN	_	12	compound	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	6	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	an	a	DT	DT	_	19	det	_	_
15	unrearranged	unrearranged	JJ	JJ	_	19	amod	_	_
16	2.3-kb	2.3-kb	JJ	JJ	_	19	amod	_	_
17	TcR	tcr	NN	NN	_	19	compound	_	_
18	delta	delta	NN	NN	_	19	compound	_	_
19	transcript	transcript	NN	NN	_	12	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	analyzed	analyze	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	14	det	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TcR	tcr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	delta	delta	NN	NN	_	14	compound	_	_
14	transcripts	transcript	NNS	NNS	_	5	dobj	_	_
15	expressed	express	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	CD3-CD16+	cd3-cd16+	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	investigated	investigate	VBD	VBD	_	5	conj	_	_
22	whether	whether	IN	IN	_	25	mark	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	25	nsubj	_	_
25	expressed	express	VBD	VBD	_	21	ccomp	_	_
26	the	the	DT	DT	_	31	det	_	_
27	hGATA-3	hgata-3	NN	NN	_	31	compound	_	_
28	T	t	NN	NN	_	31	compound	_	_
29	cell	cell	NN	NN	_	31	compound	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	25	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	37	det	_	_
34	recombination-activating	recombination-activating	JJ	JJ	_	37	amod	_	_
35	gene	gene	NN	NN	_	37	compound	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	RAG	rag	NN	NN	_	31	conj	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	-1	-1	CD	CD	_	37	nummod	_	_
40	.	.	.	.	_	5	punct	_	_

1	Multiple	multiple	JJ	JJ	_	4	amod	_	_
2	TcR	tcr	NN	NN	_	4	compound	_	_
3	delta	delta	NN	NN	_	4	compound	_	_
4	transcripts	transcript	NNS	NNS	_	13	nsubjpass	_	_
5	deriving	derive	VBG	VBG	_	4	acl	_	_
6	from	from	IN	IN	_	11	case	_	_
7	an	a	DT	DT	_	11	det	_	_
8	unrearranged	unrearranged	JJ	JJ	_	11	amod	_	_
9	TcR	tcr	NN	NN	_	11	compound	_	_
10	delta	delta	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	5	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	detected	detect	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	26	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	polyclonal	polyclonal	JJ	JJ	_	26	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	clonal	clonal	JJ	JJ	_	16	conj	_	_
19	CD3-CD16+	cd3-cd16+	JJ	JJ	_	26	amod	_	_
20	natural	natural	JJ	JJ	_	21	amod	_	_
21	killer	killer	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NK	nk	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	13	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	unrearranged	unrearranged	JJ	JJ	_	5	amod	_	_
3	TcR	tcr	NN	NN	_	5	compound	_	_
4	delta	delta	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	6	nsubj	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	size	size	NN	NN	_	6	dobj	_	_
9	similar	similar	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	that	that	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	functional	functional	JJ	JJ	_	17	amod	_	_
15	TcR	tcr	NN	NN	_	17	compound	_	_
16	delta	delta	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	11	nmod	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	2.3	2.3	CD	CD	_	22	nummod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	1.3	1.3	CD	CD	_	19	conj	_	_
22	kb	kb	NN	NN	_	17	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	found	find	VBN	VBN	_	17	acl	_	_
25	in	in	IN	IN	_	29	case	_	_
26	TcR	tcr	NN	NN	_	27	nmod:npmod	_	_
27	gamma/delta+	gamma/delta+	JJ	JJ	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	nine	nine	CD	CD	_	8	nummod	_	_
5	different	different	JJ	JJ	_	8	amod	_	_
6	2.3-kb	2.3-kb	JJ	JJ	_	8	amod	_	_
7	cDNA	cdna	NN	NN	_	8	compound	_	_
8	clones	clone	NNS	NNS	_	2	nmod	_	_
9	obtained	obtain	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	13	case	_	_
11	NK-derived	nk-derived	JJ	JJ	_	13	amod	_	_
12	polyA+	polya+	JJ	JJ	_	13	amod	_	_
13	RNA	rna	NN	NN	_	9	nmod	_	_
14	confirmed	confirm	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	corresponded	correspond	VBD	VBD	_	14	ccomp	_	_
18	to	to	TO	TO	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	unrearranged	unrearranged	JJ	JJ	_	23	amod	_	_
21	TcR	tcr	NN	NN	_	23	compound	_	_
22	delta	delta	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cDNA	cdna	NN	NN	_	6	nsubj	_	_
3	were	be	VBD	VBD	_	6	cop	_	_
4	2343	2343	CD	CD	_	5	nummod	_	_
5	bp	bp	NN	NN	_	6	nmod:npmod	_	_
6	long	long	JJ	JJ	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	initiation	initiation	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	13	nsubj	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	located	located	JJ	JJ	_	6	conj	_	_
14	814	814	CD	CD	_	15	nummod	_	_
15	bp	bp	NN	NN	_	16	nmod:npmod	_	_
16	upstream	upstream	RB	RB	_	13	advmod	_	_
17	from	from	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	J	j	NN	NN	_	22	compound	_	_
20	delta	delta	NN	NN	_	22	compound	_	_
21	1	1	CD	CD	_	22	nummod	_	_
22	segment	segment	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	11	nsubj	_	_
3	located	located	JJ	JJ	_	2	amod	_	_
4	upstream	upstream	RB	RB	_	3	advmod	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	J	j	NN	NN	_	10	compound	_	_
8	delta	delta	NN	NN	_	10	compound	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	segment	segment	NN	NN	_	4	nmod	_	_
11	corresponded	correspond	VBD	VBD	_	0	root	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	previously	previously	RB	RB	_	15	advmod	_	_
15	reported	report	VBN	VBN	_	17	amod	_	_
16	germ-line	germ-line	JJ	JJ	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	J	j	NN	NN	_	5	compound	_	_
3	delta	delta	NN	NN	_	5	compound	_	_
4	1	1	CD	CD	_	5	nummod	_	_
5	segment	segment	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	correctly	correctly	RB	RB	_	8	advmod	_	_
8	spliced	splice	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	C	c	NN	NN	_	11	compound	_	_
11	delta	delta	NN	NN	_	8	nmod	_	_
12	;	;	:	:	_	8	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	addition	addition	NN	NN	_	21	nmod	_	_
15	the	the	DT	DT	_	19	det	_	_
16	four	four	CD	CD	_	19	nummod	_	_
17	C	c	NN	NN	_	19	compound	_	_
18	delta	delta	NN	NN	_	19	compound	_	_
19	exons	exon	NNS	NNS	_	21	nsubjpass	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	found	find	VBN	VBN	_	8	parataxis	_	_
22	to	to	TO	TO	_	25	mark	_	_
23	be	be	VB	VB	_	25	auxpass	_	_
24	already	already	RB	RB	_	25	advmod	_	_
25	assembled	assemble	VBN	VBN	_	21	xcomp	_	_
26	.	.	.	.	_	8	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	polyadenylation	polyadenylation	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	present	present	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	fourth	fourth	JJ	JJ	_	11	amod	_	_
9	C	c	NN	NN	_	11	compound	_	_
10	delta	delta	NN	NN	_	11	compound	_	_
11	exon	exon	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	only	only	JJ	JJ	_	10	nsubj	_	_
4	that	that	WDT	WDT	_	3	dep	_	_
5	located	located	JJ	JJ	_	3	amod	_	_
6	at	at	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	3'	3'	JJ	JJ	_	9	amod	_	_
9	end	end	NN	NN	_	5	nmod	_	_
10	appeared	appear	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	utilized	utilize	VBN	VBN	_	10	xcomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	2.3-kb	2.3-kb	JJ	JJ	_	17	amod	_	_
17	cDNA	cdna	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	26	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	hGATA-3	hgata-3	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	T	t	NN	NN	_	8	nmod:npmod	_	_
8	cell-specific	cell-specific	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	4	appos	_	_
10	known	know	VBN	VBN	_	9	acl	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	involved	involve	VBN	VBN	_	10	xcomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	regulation	regulation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	transcription	transcription	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	TcR	tcr	NN	NN	_	23	compound	_	_
22	delta	delta	NN	NN	_	23	compound	_	_
23	locus	locus	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	4	punct	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	analyzed	analyze	VBN	VBN	_	0	root	_	_
27	by	by	IN	IN	_	29	case	_	_
28	Northern	northern	NN	NN	_	29	compound	_	_
29	blot	blot	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	26	punct	_	_
31	in	in	IN	IN	_	33	case	_	_
32	cultured	culture	VBN	VBN	_	33	amod	_	_
33	NK	nk	NN	NN	_	26	nmod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	population	population	NN	NN	_	33	dep	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	clones	clone	NNS	NNS	_	35	conj	_	_
38	(	(	-LRB-	-LRB-	_	33	punct	_	_
39	but	but	CC	CC	_	33	cc	_	_
40	not	not	RB	RB	_	45	neg	_	_
41	in	in	IN	IN	_	45	case	_	_
42	freshly	freshly	RB	RB	_	43	advmod	_	_
43	derived	derive	VBN	VBN	_	45	amod	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	populations	population	NNS	NNS	_	33	conj	_	_
46	)	)	-RRB-	-RRB-	_	33	punct	_	_
47	.	.	.	.	_	26	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	NK	nk	NN	NN	_	9	nsubjpass	_	_
3	clones	clone	NNS	NNS	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	3	conj	_	_
7	studied	study	VBN	VBN	_	2	acl	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	express	express	VB	VB	_	9	xcomp	_	_
12	hGATA-3-specific	hgata-3-specific	JJ	JJ	_	13	amod	_	_
13	mRNA	mrna	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	11	punct	_	_
15	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	hGATA-3	hgata-3	NN	NN	_	20	nsubjpass	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	15	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	30	case	_	_
25	the	the	DT	DT	_	30	det	_	_
26	unrearranged	unrearranged	JJ	JJ	_	30	amod	_	_
27	TcR	tcr	NN	NN	_	30	compound	_	_
28	delta	delta	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	23	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	NK	nk	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	transcription	transcription	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	RAG-1	rag-1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	could	could	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	all	all	DT	DT	_	14	det	_	_
14	NK	nk	NN	NN	_	11	nmod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	14	dep	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	clones	clone	NNS	NNS	_	16	conj	_	_
19	analyzed	analyze	VBN	VBN	_	14	acl	_	_
20	.	.	.	.	_	11	punct	_	_

1	Cell-specific	cell-specific	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	helix-loop-helix	helix-loop-helix	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	encoded	encode	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	E2A	e2a	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	E2A	e2a	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	helix-loop-helix	helix-loop-helix	JJ	JJ	_	10	amod	_	_
10	family	family	NN	NN	_	6	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	implicated	implicate	VBN	VBN	_	6	acl:relcl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	cell-specific	cell-specific	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	13	nmod	_	_
18	as	as	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	dimeric	dimeric	JJ	JJ	_	22	amod	_	_
22	complexes	complex	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	interact	interact	VBP	VBP	_	22	acl:relcl	_	_
25	with	with	IN	IN	_	29	case	_	_
26	E	e	NN	NN	_	29	compound	_	_
27	box	box	NN	NN	_	29	compound	_	_
28	enhancer	enhancer	NN	NN	_	29	compound	_	_
29	elements	element	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	previously	previously	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	transcripts	transcript	NNS	NNS	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	E2A	e2a	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	5	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	wide	wide	JJ	JJ	_	18	amod	_	_
18	range	range	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	types	type	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	mouse	mouse	NN	NN	_	10	compound	_	_
9	E2A	e2a	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	5	nmod	_	_
15	using	use	VBG	VBG	_	4	xcomp	_	_
16	polyclonal	polyclonal	JJ	JJ	_	17	amod	_	_
17	antisera	antisera	NNS	NNS	_	15	dobj	_	_
18	directed	direct	VBN	VBN	_	17	acl	_	_
19	against	against	IN	IN	_	21	case	_	_
20	distinct	distinct	JJ	JJ	_	21	amod	_	_
21	portions	portion	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	E2A	e2a	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	probe	probe	NN	NN	_	15	advcl	_	_
28	blots	blot	NNS	NNS	_	27	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	cellular	cellular	JJ	JJ	_	31	amod	_	_
31	extracts	extract	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	73	73	CD	CD	_	4	nummod	_	_
3	kDa	kda	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	analysis	analysis	NN	NN	_	6	nmod	_	_
10	:	:	:	:	_	6	punct	_	_
11	this	this	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	highly	highly	RB	RB	_	15	advmod	_	_
15	enriched	enrich	VBN	VBN	_	6	parataxis	_	_
16	in	in	IN	IN	_	18	case	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	origin	origin	NN	NN	_	18	nmod	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	compared	compare	VBN	VBN	_	15	advcl	_	_
25	to	to	TO	TO	_	27	case	_	_
26	pancreatic	pancreatic	JJ	JJ	_	27	amod	_	_
27	beta-cells	beta-cell	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	fibroblast	fibroblast	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	conj	_	_
31	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	detection	detection	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	selectively	selectively	RB	RB	_	8	advmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	extracts	extract	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	correlates	correlate	VBZ	VBZ	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	E	e	NN	NN	_	19	nmod:npmod	_	_
19	box-binding	box-binding	JJ	JJ	_	21	amod	_	_
20	activity	activity	NN	NN	_	21	compound	_	_
21	LEF1/BCF1	lef1/bcf1	NN	NN	_	15	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	15	nmod	_	_
25	;	;	:	:	_	12	punct	_	_
26	this	this	DT	DT	_	28	det	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	31	nsubjpass	_	_
29	was	be	VBD	VBD	_	31	auxpass	_	_
30	previously	previously	RB	RB	_	31	advmod	_	_
31	shown	show	VBN	VBN	_	12	parataxis	_	_
32	to	to	TO	TO	_	35	mark	_	_
33	be	be	VB	VB	_	35	auxpass	_	_
34	efficiently	efficiently	RB	RB	_	35	advmod	_	_
35	recognized	recognize	VBN	VBN	_	31	xcomp	_	_
36	by	by	IN	IN	_	37	case	_	_
37	antiserum	antiserum	NN	NN	_	35	nmod	_	_
38	directed	direct	VBN	VBN	_	37	acl	_	_
39	against	against	IN	IN	_	42	case	_	_
40	E2A	e2a	NN	NN	_	42	compound	_	_
41	gene	gene	NN	NN	_	42	compound	_	_
42	products	product	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	31	punct	_	_

1	Transfection	transfection	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	8	case	_	_
5	full	full	JJ	JJ	_	8	amod	_	_
6	length	length	NN	NN	_	8	compound	_	_
7	E2A	e2a	NN	NN	_	8	compound	_	_
8	cDNA	cdna	NN	NN	_	1	nmod	_	_
9	leads	lead	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	appearance	appearance	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	protein	protein	NN	NN	_	11	nmod	_	_
14	co-migrating	co-migrate	VBG	VBG	_	13	dep	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	73	73	CD	CD	_	19	nummod	_	_
18	kDa	kda	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	14	nmod	_	_
20	on	on	IN	IN	_	23	case	_	_
21	SDS	sds	NN	NN	_	23	compound	_	_
22	gel	gel	NN	NN	_	23	compound	_	_
23	electrophoresis	electrophoresis	NN	NN	_	14	nmod	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	co-migrating	co-migrate	VBG	VBG	_	14	conj	_	_
26	with	with	IN	IN	_	27	case	_	_
27	LEF1/BCF1	lef1/bcf1	NN	NN	_	25	nmod	_	_
28	on	on	IN	IN	_	31	case	_	_
29	mobility	mobility	NN	NN	_	31	compound	_	_
30	shift	shift	NN	NN	_	31	compound	_	_
31	analysis	analysis	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	view	view	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	12	amod	_	_
11	activity	activity	NN	NN	_	12	compound	_	_
12	LEF1/BCF1	lef1/bcf1	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	a	a	DT	DT	_	15	det	_	_
15	homodimer	homodimer	NN	NN	_	7	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	E2A	e2a	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	;	;	:	:	_	4	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	selective	selective	JJ	JJ	_	22	amod	_	_
22	appearance	appearance	NN	NN	_	33	nsubj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	this	this	DT	DT	_	28	det	_	_
25	putative	putative	JJ	JJ	_	28	amod	_	_
26	cell-specific	cell-specific	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	22	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	B	b	NN	NN	_	32	compound	_	_
31	lymphoid	lymphoid	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	22	nmod	_	_
33	seems	seem	VBZ	VBZ	_	4	parataxis	_	_
34	to	to	TO	TO	_	36	mark	_	_
35	be	be	VB	VB	_	36	cop	_	_
36	attributable	attributable	JJ	JJ	_	33	xcomp	_	_
37	,	,	,	,	_	48	punct	_	_
38	at	at	IN	IN	_	41	advmod	_	_
39	least	least	JJS	JJS	_	38	mwe	_	_
40	in	in	IN	IN	_	41	case	_	_
41	part	part	NN	NN	_	48	nmod	_	_
42	,	,	,	,	_	48	punct	_	_
43	to	to	TO	TO	_	48	case	_	_
44	the	the	DT	DT	_	48	det	_	_
45	elevated	elevated	JJ	JJ	_	48	amod	_	_
46	E2A	e2a	NN	NN	_	48	compound	_	_
47	protein	protein	NN	NN	_	48	compound	_	_
48	concentrations	concentration	NNS	NNS	_	36	nmod	_	_
49	in	in	IN	IN	_	51	case	_	_
50	these	these	DT	DT	_	51	det	_	_
51	cells	cell	NNS	NNS	_	48	nmod	_	_
52	.	.	.	.	_	33	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
2	Nef	nef	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	recruitment	recruitment	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	human	human	JJ	JJ	_	9	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
4	virus	virus	NN	NN	_	9	compound	_	_
5	type	type	NN	NN	_	9	compound	_	_
6	1	1	CD	CD	_	9	nummod	_	_
7	long	long	JJ	JJ	_	9	amod	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	repeat	repeat	NN	NN	_	13	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	HIV-1-LTR	hiv-1-ltr	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	contains	contain	VBZ	VBZ	_	0	root	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	20	case	_	_
17	several	several	JJ	JJ	_	20	amod	_	_
18	cellular	cellular	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	15	nmod	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	contribute	contribute	VBP	VBP	_	20	acl:relcl	_	_
23	to	to	TO	TO	_	26	case	_	_
24	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	12	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	function	function	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	HIV-1-encoded	hiv-1-encoded	JJ	JJ	_	11	amod	_	_
10	Nef	nef	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	suggested	suggest	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	Nef	nef	NN	NN	_	20	nsubj	_	_
15	may	may	MD	MD	_	20	aux	_	_
16	be	be	VB	VB	_	20	cop	_	_
17	an	a	DT	DT	_	20	det	_	_
18	inhibitor	inhibitor	NN	NN	_	20	compound	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	12	ccomp	_	_
21	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	24	advcl	_	_
3	whether	whether	IN	IN	_	5	mark	_	_
4	Nef	nef	NN	NN	_	5	nsubj	_	_
5	affects	affect	VBZ	VBZ	_	2	ccomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	implicated	implicate	VBN	VBN	_	7	acl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	24	punct	_	_
16	32P-labeled	32p-labeled	JJ	JJ	_	17	amod	_	_
17	oligonucleotides	oligonucleotide	NNS	NNS	_	24	nsubjpass	_	_
18	corresponding	correspond	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	binding	bind	VBG	VBG	_	22	amod	_	_
22	sites	site	NNS	NNS	_	18	nmod	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	incubated	incubate	VBN	VBN	_	0	root	_	_
25	with	with	IN	IN	_	27	case	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	extracts	extract	NNS	NNS	_	24	nmod	_	_
28	prepared	prepare	VBN	VBN	_	27	acl	_	_
29	from	from	IN	IN	_	32	case	_	_
30	Nef-expressing	nef-expressing	JJ	JJ	_	32	amod	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	28	nmod	_	_
33	that	that	WDT	WDT	_	36	nsubjpass	_	_
34	were	be	VBD	VBD	_	36	auxpass	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	stimulated	stimulate	VBN	VBN	_	32	acl:relcl	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	stimulated	stimulate	VBN	VBN	_	36	conj	_	_
40	with	with	IN	IN	_	42	case	_	_
41	T-cell	t-cell	NN	NN	_	42	compound	_	_
42	mitogens	mitogen	NNS	NNS	_	36	nmod	_	_
43	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	Nef	nef	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	2	ccomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	recruitment	recruitment	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	AP-1	ap-1	NN	NN	_	11	compound	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	mitogen-stimulated	mitogen-stimulated	JJ	JJ	_	15	amod	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Additionally	additionally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Nef	nef	NN	NN	_	5	compound	_	_
4	expressing	expressing	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	transiently	transiently	RB	RB	_	8	advmod	_	_
8	transfected	transfect	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	plasmid	plasmid	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	which	which	WDT	WDT	_	20	nmod	_	_
14	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
15	AP-1	ap-1	NN	NN	_	18	compound	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	recognition	recognition	NN	NN	_	18	compound	_	_
18	sequences	sequence	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	cloned	clone	VBN	VBN	_	11	acl:relcl	_	_
21	downstream	downstream	RB	RB	_	20	advmod	_	_
22	of	of	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	chloramphenicol	chloramphenicol	NN	NN	_	25	compound	_	_
25	acetyltransferase	acetyltransferase	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CAT	cat	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	gene	gene	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Mitogen-mediated	mitogen-mediated	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CAT	cat	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	construct	construct	NN	NN	_	3	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	Nef-expressing	nef-expressing	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	not	not	RB	RB	_	20	neg	_	_
18	in	in	IN	IN	_	20	case	_	_
19	control	control	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	conj	_	_
21	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	,	,	,	,	_	13	punct	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	inhibiting	inhibit	VBG	VBG	_	13	advcl	_	_
8	AP-1	ap-1	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	13	punct	_	_
11	Nef	nef	NN	NN	_	13	nsubj	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	play	play	VB	VB	_	3	ccomp	_	_
14	a	a	DT	DT	_	15	det	_	_
15	role	role	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	regulating	regulate	VBG	VBG	_	13	advcl	_	_
18	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	infected	infected	JJ	JJ	_	23	amod	_	_
23	T-cells	t-cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Hypertension	hypertension	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	3	case	_	_
3	pregnancy	pregnancy	NN	NN	_	1	nmod	_	_
4	.	.	.	.	_	1	punct	_	_

1	Pregnancy-induced	pregnancy-induced	JJ	JJ	_	2	amod	_	_
2	hypertension	hypertension	NN	NN	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PIH	pih	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	frequent	frequent	JJ	JJ	_	9	amod	_	_
9	cause	cause	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	maternal	maternal	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	neonatal	neonatal	JJ	JJ	_	11	conj	_	_
14	morbidity	morbidity	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	mortality	mortality	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	focused	focus	VBD	VBD	_	0	root	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pathophysiology	pathophysiology	NN	NN	_	6	advcl	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PIH	pih	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	mainly	mainly	RB	RB	_	16	advmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	9	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	mineralocorticoids	mineralocorticoid	NNS	NNS	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	reversed	reverse	VBN	VBN	_	23	amod	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	pressure	pressure	NN	NN	_	23	compound	_	_
23	patterns	pattern	NNS	NNS	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	resulting	result	VBG	VBG	_	28	amod	_	_
28	necessity	necessity	NN	NN	_	16	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	continuous	continuous	JJ	JJ	_	31	amod	_	_
31	monitoring	monitoring	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	preeclamptic	preeclamptic	JJ	JJ	_	35	amod	_	_
35	mother	mother	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	Problems	problem	NNS	NNS	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	antihypertensive	antihypertensive	JJ	JJ	_	4	amod	_	_
4	therapy	therapy	NN	NN	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	discussed	discuss	VBN	VBN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	10	det	_	_
9	first	first	JJ	JJ	_	10	amod	_	_
10	results	result	NNS	NNS	_	18	nsubjpass	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	pilot	pilot	NN	NN	_	14	compound	_	_
14	study	study	NN	NN	_	10	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	Urapidil	urapidil	NN	NN	_	14	nmod	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	presented	present	VBN	VBN	_	6	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	14	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	mineralocorticoids	mineralocorticoid	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pathophysiology	pathophysiology	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PIH	pih	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	studied	study	VBD	VBD	_	0	root	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	aldosterone	aldosterone	NN	NN	_	22	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	18-hydroxy-corticosterone	18-hydroxy-corticosterone	NN	NN	_	16	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	18-OH-B	18-oh-b	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	levels	level	NNS	NNS	_	14	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	25	25	CD	CD	_	25	nummod	_	_
25	women	woman	NNS	NNS	_	22	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	PIH	pih	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	in	in	IN	IN	_	33	case	_	_
30	25	25	CD	CD	_	33	nummod	_	_
31	healthy	healthy	JJ	JJ	_	33	amod	_	_
32	pregnant	pregnant	JJ	JJ	_	33	amod	_	_
33	women	woman	NNS	NNS	_	25	conj	_	_
34	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	evaluated	evaluate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	mineralocorticoid	mineralocorticoid	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MR	mr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	count	count	NN	NN	_	4	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	leukocytes	leukocyte	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	2	2	CD	CD	_	18	nummod	_	_
18	groups	group	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	MR-count	mr-count	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	significantly	significantly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	PIH-group	pih-group	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	values	value	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	plasma	plasma	NN	NN	_	5	compound	_	_
5	aldosterone	aldosterone	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	18-OH-B	18-oh-b	NN	NN	_	5	conj	_	_
8	were	be	VBD	VBD	_	10	cop	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	low	low	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	6	nsubjpass	_	_
3	can	can	MD	MD	_	6	aux	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	explained	explain	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	down-regulation	down-regulation	NN	NN	_	6	nmod	_	_
10	due	due	JJ	JJ	_	13	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	higher	higher	JJR	JJR	_	13	amod	_	_
13	level	level	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	mineralocorticoids	mineralocorticoid	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	zona	zona	NN	NN	_	19	compound	_	_
19	glomerulosa	glomerulosa	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Perhaps	perhaps	RB	RB	_	9	advmod	_	_
2	deoxycorticosterone	deoxycorticosterone	NN	NN	_	9	nsubj	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	a	a	DT	DT	_	7	det	_	_
5	hitherto	hitherto	RB	RB	_	7	advmod	_	_
6	unknown	unknown	JJ	JJ	_	7	amod	_	_
7	mineralocorticoid	mineralocorticoid	NN	NN	_	2	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	responsible	responsible	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	hypertension	hypertension	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	altered	altered	JJ	JJ	_	15	amod	_	_
15	MR-status	mr-status	NN	NN	_	12	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	21	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	continuous	continuous	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	pressure	pressure	NN	NN	_	8	compound	_	_
8	measurements	measurement	NNS	NNS	_	3	nmod	_	_
9	with	with	IN	IN	_	16	case	_	_
10	a	a	DT	DT	_	16	det	_	_
11	noninvasive	noninvasive	JJ	JJ	_	16	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	real-time	real-time	JJ	JJ	_	11	dep	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	pressure	pressure	NN	NN	_	16	compound	_	_
16	monitor	monitor	NN	NN	_	8	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Finapres	finapres	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	presented	present	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	comparison	comparison	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	obtained	obtain	VBN	VBN	_	6	amod	_	_
6	values	value	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	intraarterial	intraarterial	JJ	JJ	_	9	amod	_	_
9	measurements	measurement	NNS	NNS	_	2	nmod	_	_
10	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	good	good	JJ	JJ	_	13	amod	_	_
13	correlation	correlation	NN	NN	_	10	dobj	_	_
14	between	between	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	two	two	CD	CD	_	17	nummod	_	_
17	methods	method	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	experiences	experience	NNS	NNS	_	3	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	Urapidil	urapidil	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	treatment	treatment	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	hypertension	hypertension	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	severe	severe	JJ	JJ	_	17	amod	_	_
17	preeclampsia	preeclampsia	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	hypertension	hypertension	NN	NN	_	11	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	preeclamptic	preeclamptic	JJ	JJ	_	8	amod	_	_
8	women	woman	NNS	NNS	_	5	nmod	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	treated	treat	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Urapidil	urapidil	NN	NN	_	11	nmod	_	_
14	without	without	IN	IN	_	16	case	_	_
15	side	side	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	11	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	reflex-tachycardia	reflex-tachycardia	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	prove	prove	VB	VB	_	4	xcomp	_	_
7	if	if	IN	IN	_	10	mark	_	_
8	Urapidil	urapidil	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	suited	suit	VBN	VBN	_	6	advcl	_	_
11	for	for	IN	IN	_	13	case	_	_
12	prepartal	prepartal	JJ	JJ	_	13	amod	_	_
13	treatment	treatment	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	PIH	pih	NN	NN	_	13	nmod	_	_
16	as	as	RB	RB	_	10	advmod	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	.	.	.	.	_	4	punct	_	_

1	Aldosterone-specific	aldosterone-specific	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	rapid	rapid	JJ	JJ	_	7	amod	_	_
6	non-genomic	non-genomic	JJ	JJ	_	7	amod	_	_
7	actions	action	NNS	NNS	_	3	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	mineralocorticoids	mineralocorticoid	NNS	NNS	_	7	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	20	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	extrarenal	extrarenal	JJ	JJ	_	7	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	non-epithelial	non-epithelial	JJ	JJ	_	4	dep	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	such	such	JJ	JJ	_	12	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	smooth	smooth	JJ	JJ	_	12	amod	_	_
11	muscle	muscle	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	recently	recently	RB	RB	_	18	advmod	_	_
16	circulating	circulate	VBG	VBG	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	12	conj	_	_
19	have	have	VBP	VBP	_	20	aux	_	_
20	provided	provide	VBN	VBN	_	0	root	_	_
21	increasing	increase	VBG	VBG	_	22	amod	_	_
22	evidence	evidence	NN	NN	_	20	dobj	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	aldosterone	aldosterone	NN	NN	_	25	nsubj	_	_
25	produces	produce	VBZ	VBZ	_	22	ccomp	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	only	only	RB	RB	_	30	cc:preconj	_	_
28	classical	classical	JJ	JJ	_	30	amod	_	_
29	genomic	genomic	JJ	JJ	_	30	amod	_	_
30	effects	effect	NNS	NNS	_	25	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	but	but	CC	CC	_	30	cc	_	_
33	also	also	RB	RB	_	37	advmod	_	_
34	rapid	rapid	JJ	JJ	_	37	amod	_	_
35	,	,	,	,	_	34	punct	_	_
36	non-genomic	non-genomic	JJ	JJ	_	34	dep	_	_
37	effects	effect	NNS	NNS	_	30	conj	_	_
38	on	on	IN	IN	_	41	case	_	_
39	transmembrane	transmembrane	NN	NN	_	41	compound	_	_
40	electrolyte	electrolyte	NN	NN	_	41	compound	_	_
41	movements	movement	NNS	NNS	_	30	nmod	_	_
42	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	involve	involve	VBP	VBP	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	sodium/proton	sodium/proton	NN	NN	_	7	compound	_	_
7	exchanger	exchanger	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	membrane	membrane	NN	NN	_	7	nmod	_	_
12	at	at	IN	IN	_	17	case	_	_
13	very	very	RB	RB	_	14	advmod	_	_
14	low	low	JJ	JJ	_	17	amod	_	_
15	,	,	,	,	_	14	punct	_	_
16	physiological	physiological	JJ	JJ	_	14	dep	_	_
17	concentrations	concentration	NNS	NNS	_	3	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	aldosterone	aldosterone	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	acute	acute	JJ	JJ	_	23	amod	_	_
23	onset	onset	NN	NN	_	3	nmod	_	_
24	within	within	IN	IN	_	26	case	_	_
25	1-2	1-2	CD	CD	_	26	nummod	_	_
26	min	min	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	second	second	JJ	JJ	_	4	amod	_	_
3	messenger	messenger	NN	NN	_	4	compound	_	_
4	cascade	cascade	NN	NN	_	10	nsubj	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	the	the	DT	DT	_	10	det	_	_
8	inositol	inositol	NN	NN	_	10	compound	_	_
9	1,4,5-trisphosphate/calcium	1,4,5-trisphosphate/calcium	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	0	root	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	responds	respond	VBZ	VBZ	_	10	acl:relcl	_	_
13	over	over	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	same	same	JJ	JJ	_	18	amod	_	_
16	rapid	rapid	JJ	JJ	_	18	amod	_	_
17	time	time	NN	NN	_	18	compound	_	_
18	course	course	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	changes	change	NNS	NNS	_	7	nsubjpass	_	_
3	clearly	clearly	RB	RB	_	7	advmod	_	_
4	can	can	MD	MD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	explained	explain	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	genomic	genomic	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	responsible	responsible	JJ	JJ	_	10	acl:relcl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	later	later	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	14	nmod	_	_
18	than	than	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	membrane	membrane	NN	NN	_	21	nmod:npmod	_	_
21	related	related	JJ	JJ	_	23	amod	_	_
22	rapid	rapid	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	14	nsubjpass	_	_
3	underlying	underlie	VBG	VBG	_	2	acl	_	_
4	these	these	DT	DT	_	6	det	_	_
5	rapid	rapid	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	aldosterone	aldosterone	NN	NN	_	6	nmod	_	_
9	on	on	IN	IN	_	10	case	_	_
10	electrolytes	electrolyte	NNS	NNS	_	6	nmod	_	_
11	have	have	VBP	VBP	_	14	aux	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	extensively	extensively	RB	RB	_	14	advmod	_	_
14	studied	study	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	thus	thus	RB	RB	_	22	advmod	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	represent	represent	VB	VB	_	17	acl:relcl	_	_
23	valuable	valuable	JJ	JJ	_	24	amod	_	_
24	tools	tool	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	delineation	delineation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	receptor-effector	receptor-effector	JJ	JJ	_	31	amod	_	_
31	mechanisms	mechanism	NNS	NNS	_	27	nmod	_	_
32	involved	involve	VBN	VBN	_	31	acl	_	_
33	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	unique	unique	JJ	JJ	_	3	amod	_	_
3	characteristics	characteristic	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	pathway	pathway	NN	NN	_	3	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	action	action	NN	NN	_	7	nmod	_	_
11	include	include	VBP	VBP	_	0	root	_	_
12	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
13	rapid	rapid	JJ	JJ	_	15	amod	_	_
14	time	time	NN	NN	_	15	compound	_	_
15	course	course	NN	NN	_	11	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	10,000-fold	10,000-fold	JJ	JJ	_	18	amod	_	_
18	selectivity	selectivity	NN	NN	_	15	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	aldosterone	aldosterone	NN	NN	_	18	nmod	_	_
21	over	over	IN	IN	_	22	case	_	_
22	cortisol	cortisol	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ineffectiveness	ineffectiveness	NN	NN	_	15	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	spironolactones	spironolactone	NNS	NNS	_	25	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	classical	classical	JJ	JJ	_	31	amod	_	_
30	mineralocorticoid	mineralocorticoid	NN	NN	_	31	compound	_	_
31	antagonists	antagonist	NNS	NNS	_	27	appos	_	_
32	,	,	,	,	_	27	punct	_	_
33	as	as	IN	IN	_	34	case	_	_
34	antagonists	antagonist	NNS	NNS	_	25	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	response	response	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	11	punct	_	_

1	Adenovirus	adenovirus	NN	NN	_	2	compound	_	_
2	E1A	e1a	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	IFN-induced	ifn-induced	JJ	JJ	_	5	amod	_	_
5	resistance	resistance	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	case	_	_
7	cytolysis	cytolysis	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	natural	natural	JJ	JJ	_	11	amod	_	_
10	killer	killer	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Infection	infection	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	target	target	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	cytopathic	cytopathic	JJ	JJ	_	7	amod	_	_
7	viruses	virus	NNS	NNS	_	1	nmod	_	_
8	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
9	IFN	ifn	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytolytic	cytolytic	JJ	JJ	_	13	amod	_	_
13	resistance	resistance	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	NK	nk	NN	NN	_	16	nmod:npmod	_	_
16	cell-mediated	cell-mediated	JJ	JJ	_	17	amod	_	_
17	cytolysis	cytolysis	NN	NN	_	13	nmod	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	20	punct	_	_
19	IFN-mediated	ifn-mediated	JJ	JJ	_	20	amod	_	_
20	cytoprotection	cytoprotection	NN	NN	_	10	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IFN-MCP	ifn-mcp	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	-RSB-	-rsb-	-RRB-	-RRB-	_	20	punct	_	_
25	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	thought	think	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	virally	virally	RB	RB	_	8	advmod	_	_
8	induced	induce	VBN	VBN	_	9	amod	_	_
9	inhibition	inhibition	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	IFN-MCP	ifn-mcp	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	secondary	secondary	JJ	JJ	_	4	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	shutdown	shutdown	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	cellular	cellular	JJ	JJ	_	20	amod	_	_
19	macromolecular	macromolecular	JJ	JJ	_	20	amod	_	_
20	synthesis	synthesis	NN	NN	_	16	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	accompanies	accompany	VBZ	VBZ	_	20	acl:relcl	_	_
23	cytopathic	cytopathic	JJ	JJ	_	25	amod	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	infections	infection	NNS	NNS	_	22	dobj	_	_
26	.	.	.	.	_	4	punct	_	_

1	Group	group	NN	NN	_	10	compound	_	_
2	C	c	NN	NN	_	10	compound	_	_
3	,	,	,	,	_	10	punct	_	_
4	adenovirus	adenovirus	NN	NN	_	5	compound	_	_
5	serotype	serotype	NN	NN	_	10	dep	_	_
6	5	5	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Ad5	ad5	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	infection	infection	NN	NN	_	11	nsubj	_	_
11	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	IFN-MCP	ifn-mcp	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cellular	cellular	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	synthesis	synthesis	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	determined	determine	VBD	VBD	_	0	root	_	_
4	if	if	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Ad5-induced	ad5-induced	JJ	JJ	_	7	amod	_	_
7	inhibition	inhibition	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IFN-MCP	ifn-mcp	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	independent	independent	JJ	JJ	_	3	advcl	_	_
12	of	of	IN	IN	_	17	case	_	_
13	adenovirus	adenovirus	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Ad	ad	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	infection	infection	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	secondary	secondary	JJ	JJ	_	11	conj	_	_
20	only	only	RB	RB	_	23	advmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	Ad	ad	NN	NN	_	23	nmod	_	_
27	early	early	JJ	JJ	_	30	amod	_	_
28	region	region	NN	NN	_	30	compound	_	_
29	1A	1a	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	E1A	e1a	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	11	advcl	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	11	punct	_	_
6	4-h	4-h	JJ	JJ	_	9	amod	_	_
7	NK	nk	NN	NN	_	9	compound	_	_
8	cytolysis	cytolysis	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	performed	perform	VBN	VBN	_	0	root	_	_
12	on	on	IN	IN	_	15	case	_	_
13	IFN-gamma-treated	ifn-gamma-treated	JJ	JJ	_	15	amod	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	infected	infect	VBN	VBN	_	15	amod	_	_
17	with	with	IN	IN	_	22	case	_	_
18	an	a	DT	DT	_	22	det	_	_
19	Ad5	ad5	NN	NN	_	22	compound	_	_
20	E1A	e1a	NN	NN	_	22	compound	_	_
21	deletion	deletion	NN	NN	_	22	compound	_	_
22	mutant	mutant	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	dl343	dl343	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	16	punct	_	_
26	or	or	CC	CC	_	16	cc	_	_
27	transfected	transfect	VBN	VBN	_	16	conj	_	_
28	with	with	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	Ad5	ad5	NN	NN	_	32	compound	_	_
31	E1A	e1a	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	IFN-MCP	ifn-mcp	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	inhibited	inhibit	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	infection	infection	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	dl343	dl343	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	despite	despite	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	production	production	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	large	large	JJ	JJ	_	15	amod	_	_
15	amounts	amount	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	early	early	JJ	JJ	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	E1B	e1b	NN	NN	_	18	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	p55	p55	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	late	late	JJ	JJ	_	18	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	hexon	hexon	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	Ad	ad	NN	NN	_	30	compound	_	_
30	proteins	protein	NNS	NNS	_	18	dep	_	_
31	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	8	case	_	_
2	contrast	contrast	NN	NN	_	8	dep	_	_
3	to	to	TO	TO	_	8	case	_	_
4	E1A-negative	e1a-negative	JJ	JJ	_	8	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	parental	parental	JJ	JJ	_	4	dep	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	12	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	IFN-MCP	ifn-mcp	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	blocked	block	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	20	case	_	_
14	Ad5	ad5	NN	NN	_	15	nmod:npmod	_	_
15	E1A-transfected	e1a-transfected	JJ	JJ	_	20	amod	_	_
16	epithelial	epithelial	JJ	JJ	_	20	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	fibroblastic	fibroblastic	JJ	JJ	_	16	conj	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	12	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Genetic	genetic	JJ	JJ	_	3	amod	_	_
2	mapping	mapping	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	8	nsubj	_	_
4	within	within	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	E1A	e1a	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	19	mark	_	_
10	expression	expression	NN	NN	_	19	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	only	only	RB	RB	_	15	advmod	_	_
13	the	the	DT	DT	_	15	det	_	_
14	first	first	JJ	JJ	_	15	amod	_	_
15	exon	exon	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	E1A	e1a	NN	NN	_	15	nmod	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	sufficient	sufficient	JJ	JJ	_	8	ccomp	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	inhibit	inhibit	VB	VB	_	19	xcomp	_	_
22	IFN-MCP	ifn-mcp	NN	NN	_	21	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	homology	homology	NN	NN	_	23	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	E1A	e1a	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	between	between	IN	IN	_	10	case	_	_
8	different	different	JJ	JJ	_	10	amod	_	_
9	Ad	ad	NN	NN	_	10	compound	_	_
10	groups	group	NNS	NNS	_	3	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	group	group	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	10	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	Ad12	ad12	NN	NN	_	13	appos	_	_
16	;	;	:	:	_	13	punct	_	_
17	group	group	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	13	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	Ad5	ad5	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	13	punct	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	limited	limit	VBN	VBN	_	0	root	_	_
24	almost	almost	RB	RB	_	25	advmod	_	_
25	entirely	entirely	RB	RB	_	29	advmod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	three	three	CD	CD	_	29	nummod	_	_
28	conserved	conserve	VBN	VBN	_	29	amod	_	_
29	regions	region	NNS	NNS	_	23	nmod	_	_
30	located	located	JJ	JJ	_	29	amod	_	_
31	within	within	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	first	first	JJ	JJ	_	34	amod	_	_
34	exon	exon	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	E1A	e1a	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	23	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	IFN-MCP	ifn-mcp	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	blocked	block	VBN	VBN	_	23	advcl	_	_
6	in	in	IN	IN	_	10	case	_	_
7	Ad12	ad12	NN	NN	_	10	compound	_	_
8	E1A-transfected	e1a-transfected	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	23	punct	_	_
12	expression	expression	NN	NN	_	23	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	one	one	CD	CD	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	more	more	JJR	JJR	_	14	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	E1A-conserved	e1a-conserved	JJ	JJ	_	20	amod	_	_
20	regions	region	NNS	NNS	_	14	nmod	_	_
21	may	may	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	necessary	necessary	JJ	JJ	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	inhibit	inhibit	VB	VB	_	23	xcomp	_	_
26	IFN-MCP	ifn-mcp	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	E1A	e1a	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	products	product	NNS	NNS	_	5	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	IFN-MCP	ifn-mcp	NN	NN	_	10	dobj	_	_
12	independently	independently	RB	RB	_	10	advmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	infection	infection	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	E1A	e1a	NN	NN	_	3	nmod:poss	_	_
2	's	's	POS	POS	_	1	case	_	_
3	inhibition	inhibition	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IFN-MCP	ifn-mcp	NN	NN	_	3	nmod	_	_
6	has	have	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	net	net	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	promoting	promote	VBG	VBG	_	9	acl	_	_
12	the	the	DT	DT	_	16	det	_	_
13	selective	selective	JJ	JJ	_	16	amod	_	_
14	NK	nk	NN	NN	_	15	nmod:npmod	_	_
15	cell-mediated	cell-mediated	JJ	JJ	_	16	amod	_	_
16	clearance	clearance	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	Ad-infected	ad-infected	JJ	JJ	_	22	amod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Ad-transformed	ad-transformed	JJ	JJ	_	18	conj	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	9	det	_	_
2	chimeric	chimeric	JJ	JJ	_	9	amod	_	_
3	type	type	NN	NN	_	9	compound	_	_
4	II	ii	CD	CD	_	9	nummod	_	_
5	/	/	:	:	_	9	punct	_	_
6	type	type	NN	NN	_	9	compound	_	_
7	I	i	CD	CD	_	9	nummod	_	_
8	interleukin-1	interleukin-1	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	mediate	mediate	VB	VB	_	0	root	_	_
12	interleukin-1	interleukin-1	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	type	type	NN	NN	_	10	nsubj	_	_
3	I	i	CD	CD	_	2	nummod	_	_
4	interleukin-1	interleukin-1	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	2	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-1R	il-1r	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	capable	capable	JJ	JJ	_	0	root	_	_
11	of	of	IN	IN	_	12	mark	_	_
12	transducing	transduce	VBG	VBG	_	10	advcl	_	_
13	a	a	DT	DT	_	14	det	_	_
14	signal	signal	NN	NN	_	12	dobj	_	_
15	resulting	result	VBG	VBG	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	transduction	transduction	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	dependent	dependent	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	consists	consist	VBZ	VBZ	_	9	acl:relcl	_	_
13	of	of	IN	IN	_	16	case	_	_
14	213	213	CD	CD	_	16	nummod	_	_
15	amino	amino	NN	NN	_	16	compound	_	_
16	acids	acid	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	contrast	contrast	NN	NN	_	7	dep	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	type	type	NN	NN	_	7	compound	_	_
6	I	i	CD	CD	_	7	nummod	_	_
7	receptor	receptor	NN	NN	_	13	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	IL-1R	il-1r	NN	NN	_	13	nsubj	_	_
13	has	have	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	small	small	JJ	JJ	_	17	amod	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
17	tail	tail	NN	NN	_	13	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	it	it	PRP	PRP	_	23	nsubj	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	clear	clear	JJ	JJ	_	13	conj	_	_
24	whether	whether	IN	IN	_	29	mark	_	_
25	this	this	DT	DT	_	26	det	_	_
26	receptor	receptor	NN	NN	_	29	nsubj	_	_
27	is	be	VBZ	VBZ	_	29	cop	_	_
28	a	a	DT	DT	_	29	det	_	_
29	signal-transducing	signal-transducing	JJ	JJ	_	23	ccomp	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	a	a	DT	DT	_	32	det	_	_
32	regulatory	regulatory	JJ	JJ	_	29	conj	_	_
33	molecule	molecule	NN	NN	_	29	dep	_	_
34	.	.	.	.	_	13	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	type	type	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	IL-1R	il-1r	NN	NN	_	11	nsubj	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	mediate	mediate	VB	VB	_	3	ccomp	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	Jurkat	jurkat	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	31	advmod	_	_
2	,	,	,	,	_	31	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	hybrid	hybrid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	31	nsubj	_	_
6	composed	compose	VBN	VBN	_	5	acl	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	extracellular	extracellular	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	transmembrane	transmembrane	NN	NN	_	9	conj	_	_
12	regions	region	NNS	NNS	_	6	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	type	type	NN	NN	_	18	compound	_	_
17	II	ii	CD	CD	_	18	nummod	_	_
18	interleukin-1	interleukin-1	NN	NN	_	12	nmod	_	_
19	fused	fuse	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cytoplasmic	cytoplasmic	JJ	JJ	_	23	amod	_	_
23	domain	domain	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	type	type	NN	NN	_	29	compound	_	_
28	I	i	CD	CD	_	29	nummod	_	_
29	IL-1R	il-1r	NN	NN	_	23	nmod	_	_
30	was	be	VBD	VBD	_	31	cop	_	_
31	capable	capable	JJ	JJ	_	0	root	_	_
32	of	of	IN	IN	_	33	mark	_	_
33	transducing	transduce	VBG	VBG	_	31	advcl	_	_
34	a	a	DT	DT	_	35	det	_	_
35	signal	signal	NN	NN	_	33	dobj	_	_
36	across	across	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	membrane	membrane	NN	NN	_	33	nmod	_	_
39	resulting	result	VBG	VBG	_	33	dep	_	_
40	in	in	IN	IN	_	42	case	_	_
41	a	a	DT	DT	_	42	det	_	_
42	pattern	pattern	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	gene	gene	NN	NN	_	45	compound	_	_
45	activation	activation	NN	NN	_	42	nmod	_	_
46	identical	identical	JJ	JJ	_	45	amod	_	_
47	to	to	TO	TO	_	48	case	_	_
48	that	that	DT	DT	_	46	nmod	_	_
49	mediated	mediate	VBN	VBN	_	48	acl	_	_
50	by	by	IN	IN	_	54	case	_	_
51	the	the	DT	DT	_	54	det	_	_
52	type	type	NN	NN	_	54	compound	_	_
53	I	i	CD	CD	_	54	nummod	_	_
54	IL-1R	il-1r	NN	NN	_	49	nmod	_	_
55	.	.	.	.	_	31	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	extracellular	extracellular	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	IL-1R	il-1r	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	capable	capable	JJ	JJ	_	3	ccomp	_	_
15	of	of	IN	IN	_	17	mark	_	_
16	functionally	functionally	RB	RB	_	17	advmod	_	_
17	interacting	interact	VBG	VBG	_	14	advcl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	interleukin-1	interleukin-1	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	transmitting	transmit	VBG	VBG	_	17	conj	_	_
22	the	the	DT	DT	_	24	det	_	_
23	resulting	result	VBG	VBG	_	24	amod	_	_
24	signal	signal	NN	NN	_	21	dobj	_	_
25	to	to	TO	TO	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	heterologous	heterologous	JJ	JJ	_	29	amod	_	_
28	cytoplasmic	cytoplasmic	JJ	JJ	_	29	amod	_	_
29	domain	domain	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	mutation	mutation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	cortisol	cortisol	NN	NN	_	10	compound	_	_
10	resistance	resistance	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	precise	precise	JJ	JJ	_	4	amod	_	_
3	molecular	molecular	JJ	JJ	_	4	amod	_	_
4	abnormalities	abnormality	NNS	NNS	_	14	nsubjpass	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	cause	cause	VBP	VBP	_	4	acl:relcl	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	cortisol	cortisol	NN	NN	_	9	compound	_	_
9	resistance	resistance	NN	NN	_	6	dobj	_	_
10	have	have	VBP	VBP	_	14	aux	_	_
11	not	not	RB	RB	_	14	neg	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	completely	completely	RB	RB	_	14	advmod	_	_
14	described	describe	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	subject	subject	NN	NN	_	10	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	primary	primary	JJ	JJ	_	7	amod	_	_
6	cortisol	cortisol	NN	NN	_	7	compound	_	_
7	resistance	resistance	NN	NN	_	3	nmod	_	_
8	we	we	PRP	PRP	_	10	nsubj	_	_
9	have	have	VBP	VBP	_	10	aux	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	10	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	hGR	hgr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	with	with	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	decreased	decrease	VBN	VBN	_	19	amod	_	_
19	affinity	affinity	NN	NN	_	12	nmod	_	_
20	for	for	IN	IN	_	21	case	_	_
21	dexamethasone	dexamethasone	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesize	hypothesize	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	a	a	DT	DT	_	5	det	_	_
5	mutation	mutation	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	hGR	hgr	NN	NN	_	10	compound	_	_
9	glucocorticoid-binding	glucocorticoid-binding	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cause	cause	NN	NN	_	2	ccomp	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cortisol	cortisol	NN	NN	_	16	compound	_	_
16	resistance	resistance	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Total	total	JJ	JJ	_	2	amod	_	_
2	RNA	rna	NN	NN	_	12	nsubjpass	_	_
3	isolated	isolate	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	index	index	NN	NN	_	7	compound	_	_
7	subject	subject	NN	NN	_	10	nmod:poss	_	_
8	's	's	POS	POS	_	7	case	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	3	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	produce	produce	VB	VB	_	12	xcomp	_	_
15	first	first	JJ	JJ	_	18	amod	_	_
16	strand	strand	NN	NN	_	18	compound	_	_
17	hGR	hgr	NN	NN	_	18	compound	_	_
18	cDNAs	cdna	NNS	NNS	_	14	dobj	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	the	the	DT	DT	_	24	det	_	_
22	entire	entire	JJ	JJ	_	24	amod	_	_
23	hGR	hgr	NN	NN	_	24	compound	_	_
24	cDNA	cdna	NN	NN	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	amplified	amplify	VBN	VBN	_	12	conj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	segments	segment	NNS	NNS	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	sequenced	sequence	VBN	VBN	_	26	conj	_	_
31	.	.	.	.	_	12	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	nucleotide	nucleotide	NN	NN	_	5	nmod	_	_
3	2,317	2,317	CD	CD	_	2	nummod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	homozygous	homozygous	JJ	JJ	_	8	amod	_	_
8	A	a	NN	NN	_	5	dobj	_	_
9	for	for	IN	IN	_	12	case	_	_
10	G	g	NN	NN	_	12	compound	_	_
11	point	point	NN	NN	_	12	compound	_	_
12	mutation	mutation	NN	NN	_	8	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	predicts	predict	VBZ	VBZ	_	12	acl:relcl	_	_
15	an	a	DT	DT	_	16	det	_	_
16	isoleucine	isoleucine	NN	NN	_	14	dobj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ATT	att	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	for	for	IN	IN	_	25	case	_	_
21	valine	valine	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	GTT	gtt	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	substitution	substitution	NN	NN	_	16	nmod	_	_
26	at	at	IN	IN	_	28	case	_	_
27	amino	amino	NN	NN	_	28	compound	_	_
28	acid	acid	NN	NN	_	25	nmod	_	_
29	729	729	CD	CD	_	28	nummod	_	_
30	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	9	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	wild-type	wild-type	JJ	JJ	_	4	amod	_	_
4	hGR	hgr	NN	NN	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	hGR-Ile	hgr-ile	NN	NN	_	4	conj	_	_
7	729	729	CD	CD	_	6	nummod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	30	advcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	COS-1	cos-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	assayed	assay	VBN	VBN	_	9	conj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	-LSB-3H-RSB--Dexamethasone	-lsb-3h-rsb--dexamethasone	NN	NN	_	17	compound	_	_
17	binding	binding	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	30	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	dissociation	dissociation	NN	NN	_	21	compound	_	_
21	constants	constant	NNS	NNS	_	30	nsubj	_	_
22	were	be	VBD	VBD	_	30	cop	_	_
23	0.799	0.799	CD	CD	_	30	nummod	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	0.068	0.068	CD	CD	_	23	conj	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	1.54	1.54	CD	CD	_	23	conj	_	_
28	+/-	+/-	CC	CC	_	27	cc	_	_
29	0.06	0.06	CD	CD	_	27	conj	_	_
30	nM	nm	NN	NN	_	0	root	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	mean	mean	NN	NN	_	30	dep	_	_
33	+/-	+/-	CC	CC	_	32	cc	_	_
34	SEM	sem	NN	NN	_	32	conj	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	P	p	NN	NN	_	39	dep	_	_
38	&lt;	&lt;	JJR	JJR	_	39	advmod	_	_
39	0.01	0.01	CD	CD	_	30	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	,	,	,	,	_	30	punct	_	_
42	respectively	respectively	RB	RB	_	30	advmod	_	_
43	.	.	.	.	_	30	punct	_	_

1	When	when	WRB	WRB	_	9	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	wild-type	wild-type	JJ	JJ	_	4	amod	_	_
4	hGR	hgr	NN	NN	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	hGR-Ile	hgr-ile	NN	NN	_	4	conj	_	_
7	729	729	CD	CD	_	6	nummod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	39	advcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	CV-1	cv-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	cotransfected	cotransfect	VBN	VBN	_	12	acl:relcl	_	_
16	with	with	IN	IN	_	24	case	_	_
17	the	the	DT	DT	_	24	det	_	_
18	mouse	mouse	NN	NN	_	24	compound	_	_
19	mammary	mammary	JJ	JJ	_	24	amod	_	_
20	tumor	tumor	NN	NN	_	24	compound	_	_
21	virus	virus	NN	NN	_	24	compound	_	_
22	long	long	JJ	JJ	_	24	amod	_	_
23	terminal	terminal	JJ	JJ	_	24	amod	_	_
24	repeat	repeat	NN	NN	_	15	nmod	_	_
25	fused	fuse	VBN	VBN	_	24	acl	_	_
26	to	to	TO	TO	_	34	case	_	_
27	the	the	DT	DT	_	34	det	_	_
28	chloramphenicol	chloramphenicol	NN	NN	_	30	compound	_	_
29	acetyl	acetyl	NN	NN	_	30	compound	_	_
30	transferase	transferase	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	CAT	cat	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	gene	gene	NN	NN	_	25	nmod	_	_
35	,	,	,	,	_	39	punct	_	_
36	the	the	DT	DT	_	37	det	_	_
37	hGR-Ile	hgr-ile	NN	NN	_	39	nsubj	_	_
38	729	729	CD	CD	_	37	nummod	_	_
39	conferred	confer	VBD	VBD	_	0	root	_	_
40	a	a	DT	DT	_	42	det	_	_
41	fourfold	fourfold	JJ	JJ	_	42	amod	_	_
42	decrease	decrease	NN	NN	_	39	dobj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	apparent	apparent	JJ	JJ	_	45	amod	_	_
45	potency	potency	NN	NN	_	42	nmod	_	_
46	on	on	IN	IN	_	48	case	_	_
47	dexamethasone	dexamethasone	NN	NN	_	48	compound	_	_
48	stimulation	stimulation	NN	NN	_	39	nmod	_	_
49	of	of	IN	IN	_	51	case	_	_
50	CAT	cat	NN	NN	_	51	compound	_	_
51	activity	activity	NN	NN	_	48	nmod	_	_
52	.	.	.	.	_	39	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	isoleucine	isoleucine	NN	NN	_	10	nsubj	_	_
3	for	for	IN	IN	_	5	case	_	_
4	valine	valine	NN	NN	_	5	compound	_	_
5	substitution	substitution	NN	NN	_	2	nmod	_	_
6	at	at	IN	IN	_	8	case	_	_
7	amino	amino	NN	NN	_	8	compound	_	_
8	acid	acid	NN	NN	_	5	nmod	_	_
9	729	729	CD	CD	_	8	nummod	_	_
10	impairs	impair	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	function	function	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	hGR	hgr	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	the	the	DT	DT	_	20	det	_	_
19	likely	likely	JJ	JJ	_	20	amod	_	_
20	cause	cause	NN	NN	_	10	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	primary	primary	JJ	JJ	_	24	amod	_	_
23	cortisol	cortisol	NN	NN	_	24	compound	_	_
24	resistance	resistance	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	subject	subject	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	Mice	mouse	NNS	NNS	_	12	nsubj	_	_
2	deficient	deficient	NN	NN	_	1	amod	_	_
3	for	for	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	55	55	CD	CD	_	6	compound	_	_
6	kd	kd	JJ	JJ	_	10	amod	_	_
7	tumor	tumor	NN	NN	_	10	compound	_	_
8	necrosis	necrosis	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	2	nmod	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	resistant	resistant	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	endotoxic	endotoxic	JJ	JJ	_	15	amod	_	_
15	shock	shock	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	yet	yet	RB	RB	_	12	advmod	_	_
18	succumb	succumb	VBP	VBP	_	12	dep	_	_
19	to	to	TO	TO	_	22	case	_	_
20	L.	l.	FW	FW	_	22	compound	_	_
21	monocytogenes	monocytogene	NNS	NNS	_	22	compound	_	_
22	infection	infection	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	multiple	multiple	JJ	JJ	_	4	amod	_	_
3	biological	biological	JJ	JJ	_	4	amod	_	_
4	activities	activity	NNS	NNS	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	tumor	tumor	NN	NN	_	8	compound	_	_
7	necrosis	necrosis	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	TNF	tnf	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	19	case	_	_
15	two	two	CD	CD	_	19	nummod	_	_
16	distinct	distinct	JJ	JJ	_	19	amod	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	surface	surface	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	55	55	CD	CD	_	22	nummod	_	_
22	kd	kd	NNS	NNS	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TNFRp55	tnfrp55	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	75	75	CD	CD	_	28	nummod	_	_
28	kd	kd	NN	NN	_	22	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TNFRp75	tnfrp75	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	13	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	targeting	targeting	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	generated	generate	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	TNFRp55-deficient	tnfrp55-deficient	JJ	JJ	_	10	amod	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	strain	strain	NN	NN	_	6	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	Cells	cell	NNS	NNS	_	5	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	TNFRp55-/-mutant	tnfrp55-/-mutant	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	1	nmod	_	_
5	lack	lack	VBP	VBP	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TNFRp55	tnfrp55	NN	NN	_	6	nmod	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	display	display	VBP	VBP	_	5	conj	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	numbers	number	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	high	high	JJ	JJ	_	17	amod	_	_
15	affinity	affinity	NN	NN	_	17	compound	_	_
16	TNFRp75	tnfrp75	NN	NN	_	17	compound	_	_
17	molecules	molecule	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Thymocyte	thymocyte	NN	NN	_	2	compound	_	_
2	development	development	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	populations	population	NNS	NNS	_	2	conj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	unaltered	unaltered	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	clonal	clonal	JJ	JJ	_	11	amod	_	_
11	deletion	deletion	NN	NN	_	19	nsubj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	potentially	potentially	RB	RB	_	14	advmod	_	_
14	self-reactive	self-reactive	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	impaired	impaired	JJ	JJ	_	7	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	TNF	tnf	NN	NN	_	4	compound	_	_
4	signaling	signaling	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	largely	largely	RB	RB	_	7	advmod	_	_
7	abolished	abolish	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	as	as	IN	IN	_	10	mark	_	_
10	judged	judge	VBN	VBN	_	7	advcl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	failure	failure	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	TNF	tnf	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	13	acl	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
23	from	from	IN	IN	_	25	case	_	_
24	TNFRp55-deficient	tnfrp55-deficient	JJ	JJ	_	25	amod	_	_
25	mice	mouse	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	loss	loss	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	TNFRp55	tnfrp55	NN	NN	_	5	compound	_	_
5	function	function	NN	NN	_	2	nmod	_	_
6	renders	render	VBZ	VBZ	_	0	root	_	_
7	mice	mouse	NNS	NNS	_	8	nsubj	_	_
8	resistant	resistant	JJ	JJ	_	6	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	lethal	lethal	JJ	JJ	_	11	amod	_	_
11	dosages	dosage	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	either	either	CC	CC	_	14	cc:preconj	_	_
14	lipopolysaccharides	lipopolysaccharide	NNS	NNS	_	11	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	S.	s.	FW	FW	_	19	compound	_	_
17	aureus	aureus	FW	FW	_	19	compound	_	_
18	enterotoxin	enterotoxin	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	14	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	TNFRp55-deficient	tnfrp55-deficient	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	8	nsubj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	severely	severely	RB	RB	_	8	advmod	_	_
8	impaired	impaired	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	clear	clear	VB	VB	_	8	xcomp	_	_
11	L.	l.	FW	FW	_	12	compound	_	_
12	monocytogenes	monocytogenes	FW	FW	_	10	dobj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	readily	readily	RB	RB	_	15	advmod	_	_
15	succumb	succumb	VBP	VBP	_	8	conj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	infection	infection	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	55	55	CD	CD	_	6	nummod	_	_
5	kd	kd	NN	NN	_	6	compound	_	_
6	TNFR	tnfr	NN	NN	_	7	nsubj	_	_
7	plays	play	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	decisive	decisive	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	host	host	NN	NN	_	15	nmod:poss	_	_
14	's	's	POS	POS	_	13	case	_	_
15	defense	defense	NN	NN	_	7	nmod	_	_
16	against	against	IN	IN	_	17	case	_	_
17	microorganisms	microorganism	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
20	pathogenic	pathogenic	JJ	JJ	_	21	amod	_	_
21	factors	factor	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	characterization	characterization	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	early	early	JJ	JJ	_	8	amod	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	regulator	regulator	NN	NN	_	8	appos	_	_
12	of	of	IN	IN	_	15	case	_	_
13	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Early	early	JJ	JJ	_	3	amod	_	_
2	B-cell	b-cell	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBF	ebf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	previously	previously	RB	RB	_	8	advmod	_	_
10	as	as	IN	IN	_	17	case	_	_
11	a	a	DT	DT	_	17	det	_	_
12	tissue-specific	tissue-specific	JJ	JJ	_	17	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	differentiation	differentiation	NN	NN	_	15	nmod:npmod	_	_
15	stage-specific	stage-specific	JJ	JJ	_	12	conj	_	_
16	DNA-binding	dna-binding	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	8	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	participates	participate	VBZ	VBZ	_	17	acl:relcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	regulation	regulation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	pre-B	pre-b	JJ	JJ	_	28	nmod:npmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	B	b	NN	NN	_	25	conj	_	_
28	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	30	amod	_	_
29	mb-1	mb-1	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	Partial	partial	JJ	JJ	_	4	amod	_	_
2	amino	amino	NN	NN	_	4	compound	_	_
3	acid	acid	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	10	nsubjpass	_	_
5	obtained	obtain	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	8	case	_	_
7	purified	purify	VBN	VBN	_	8	amod	_	_
8	EBF	ebf	NN	NN	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	isolate	isolate	VB	VB	_	10	xcomp	_	_
13	cDNA	cdna	NN	NN	_	14	compound	_	_
14	clones	clone	NNS	NNS	_	12	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	20	nsubj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	multiple	multiple	JJ	JJ	_	19	amod	_	_
19	criteria	criterion	NNS	NNS	_	20	nmod	_	_
20	encode	encode	VB	VB	_	14	acl:relcl	_	_
21	EBF	ebf	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	recombinant	recombinant	JJ	JJ	_	3	amod	_	_
3	polypeptide	polypeptide	NN	NN	_	4	nsubj	_	_
4	formed	form	VBD	VBD	_	0	root	_	_
5	sequence-specific	sequence-specific	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	4	dobj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	EBF-binding	ebf-binding	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	mb-1	mb-1	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cDNA	cdna	NN	NN	_	3	nsubj	_	_
3	hybridized	hybridize	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	multiple	multiple	JJ	JJ	_	6	amod	_	_
6	transcripts	transcript	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	pre-B	pre-b	JJ	JJ	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	B-cell	b-cell	NN	NN	_	8	conj	_	_
11	lines	line	NNS	NNS	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	but	but	CC	CC	_	3	cc	_	_
14	transcripts	transcript	NNS	NNS	_	17	nsubjpass	_	_
15	were	be	VBD	VBD	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	detected	detect	VBN	VBN	_	3	conj	_	_
18	at	at	IN	IN	_	20	case	_	_
19	significant	significant	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	29	case	_	_
22	plasmacytoma	plasmacytoma	NN	NN	_	29	compound	_	_
23	,	,	,	,	_	22	punct	_	_
24	T-cell	t-cell	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	nonlymphoid	nonlymphoid	JJ	JJ	_	22	conj	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	17	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
4	EBF	ebf	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	transfected	transfect	VBN	VBN	_	8	amod	_	_
7	nonlymphoid	nonlymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	activated	activate	VBD	VBD	_	0	root	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	from	from	IN	IN	_	14	case	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	plasmids	plasmid	NNS	NNS	_	11	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	functional	functional	JJ	JJ	_	18	amod	_	_
17	EBF-binding	ebf-binding	JJ	JJ	_	18	amod	_	_
18	sites	site	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	deletion	deletion	NN	NN	_	7	compound	_	_
7	mutants	mutant	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	EBF	ebf	NN	NN	_	7	nmod	_	_
10	identified	identify	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	15	det	_	_
12	amino-terminal	amino-terminal	JJ	JJ	_	15	amod	_	_
13	cysteine-rich	cysteine-rich	JJ	JJ	_	15	amod	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	domain	domain	NN	NN	_	10	dobj	_	_
16	lacking	lack	VBG	VBG	_	15	acl	_	_
17	obvious	obvious	JJ	JJ	_	19	amod	_	_
18	sequence	sequence	NN	NN	_	19	compound	_	_
19	similarity	similarity	NN	NN	_	16	dobj	_	_
20	to	to	TO	TO	_	23	case	_	_
21	known	known	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	DNA-binding	dna-binding	JJ	JJ	_	2	amod	_	_
2	assays	assay	NNS	NNS	_	11	nsubj	_	_
3	with	with	IN	IN	_	5	case	_	_
4	cotranslated	cotranslate	VBN	VBN	_	5	amod	_	_
5	wild-type	wild-type	JJ	JJ	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	truncated	truncated	JJ	JJ	_	5	conj	_	_
8	forms	form	NNS	NNS	_	5	dep	_	_
9	of	of	IN	IN	_	10	case	_	_
10	EBF	ebf	NN	NN	_	5	nmod	_	_
11	indicated	indicate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	protein	protein	NN	NN	_	15	nsubj	_	_
15	interacts	interact	VBZ	VBZ	_	11	ccomp	_	_
16	with	with	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	site	site	NN	NN	_	15	nmod	_	_
19	as	as	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	homodimer	homodimer	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Deletions	deletion	NNS	NNS	_	2	nsubj	_	_
2	delineated	delineate	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	carboxy-terminal	carboxy-terminal	JJ	JJ	_	6	amod	_	_
5	dimerization	dimerization	NN	NN	_	6	compound	_	_
6	region	region	NN	NN	_	2	dobj	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	repeats	repeat	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	15	15	CD	CD	_	13	nummod	_	_
12	amino	amino	NN	NN	_	13	compound	_	_
13	acids	acid	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	show	show	VBP	VBP	_	9	acl:relcl	_	_
16	similarity	similarity	NN	NN	_	15	dobj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	dimerization	dimerization	NN	NN	_	20	compound	_	_
20	domains	domain	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	basic-helix-loop-helix	basic-helix-loop-helix	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	EBF	ebf	NN	NN	_	8	nsubj	_	_
8	represents	represent	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	novel	novel	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	B	b	NN	NN	_	14	nmod:npmod	_	_
14	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	The	the	DT	DT	_	3	det	_	_
3	trend	trend	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	molecular	molecular	JJ	JJ	_	7	amod	_	_
6	biology	biology	NN	NN	_	7	compound	_	_
7	study	study	NN	NN	_	3	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	eosinophils	eosinophil	NNS	NNS	_	7	nmod	_	_
10	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Recently	recently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	many	many	JJ	JJ	_	4	amod	_	_
4	investigators	investigator	NNS	NNS	_	7	nsubj	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	cop	_	_
7	interested	interested	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	study	study	NN	NN	_	7	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	eosinophil	eosinophil	NN	NN	_	13	compound	_	_
13	biology	biology	NN	NN	_	10	nmod	_	_
14	since	since	IN	IN	_	40	mark	_	_
15	genes	gene	NNS	NNS	_	16	compound	_	_
16	association	association	NN	NN	_	40	nsubjpass	_	_
17	with	with	IN	IN	_	18	case	_	_
18	eosinophils	eosinophil	NNS	NNS	_	16	nmod	_	_
19	such	such	JJ	JJ	_	21	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	interleukin-5	interleukin-5	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	eosinophil	eosinophil	NN	NN	_	25	compound	_	_
24	granule	granule	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	21	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	EPO	epo	NN	NN	_	25	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	ECP	ecp	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	EDN	edn	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	MBP	mbp	NN	NN	_	27	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	and	and	CC	CC	_	27	cc	_	_
36	CLC	clc	NN	NN	_	27	conj	_	_
37	)	)	-RRB-	-RRB-	_	27	punct	_	_
38	,	,	,	,	_	40	punct	_	_
39	were	be	VBD	VBD	_	40	auxpass	_	_
40	isolated	isolate	VBN	VBN	_	7	advcl	_	_
41	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	18	nsubjpass	_	_
6	for	for	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	commitment	commitment	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	progenitors	progenitor	NNS	NNS	_	8	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	eosinophil	eosinophil	NN	NN	_	14	compound	_	_
14	lineage	lineage	NN	NN	_	8	nmod	_	_
15	has	have	VBZ	VBZ	_	18	aux	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	determined	determine	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	34	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	27	nmod	_	_
5	eosinophil-specific	eosinophil-specific	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	27	nsubj	_	_
7	encoding	encode	VBG	VBG	_	6	acl	_	_
8	primary	primary	JJ	JJ	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	secondary	secondary	JJ	JJ	_	8	conj	_	_
11	granule	granule	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	7	dobj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	e.g.	e.g.	FW	FW	_	15	advmod	_	_
15	ECP	ecp	NN	NN	_	12	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	EDN	edn	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	EPO	epo	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	MBP	mbp	NN	NN	_	15	conj	_	_
22	,	,	,	,	_	15	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	CLC	clc	NN	NN	_	15	conj	_	_
25	)	)	-RRB-	-RRB-	_	15	punct	_	_
26	are	be	VBP	VBP	_	27	aux	_	_
27	expressed	express	VBN	VBN	_	2	acl:relcl	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	regulated	regulate	VBN	VBN	_	27	conj	_	_
30	during	during	IN	IN	_	31	case	_	_
31	eosinophilopoiesis	eosinophilopoiesis	NN	NN	_	27	nmod	_	_
32	is	be	VBZ	VBZ	_	34	cop	_	_
33	also	also	RB	RB	_	34	advmod	_	_
34	unknown	unknown	JJ	JJ	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	I	I	PRP	PRP	_	6	nsubj	_	_
6	described	describe	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	characterization	characterization	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	genes	gene	NNS	NNS	_	8	nmod	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	eosinophil	eosinophil	NN	NN	_	14	compound	_	_
13	granule	granule	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	dobj	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	8	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	GATA-1	gata-1	NN	NN	_	23	compound	_	_
21	binding	binding	NN	NN	_	23	compound	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	18	nmod	_	_
24	during	during	IN	IN	_	26	case	_	_
25	eosinophil	eosinophil	NN	NN	_	26	compound	_	_
26	differentiation	differentiation	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	Ets-related	ets-related	JJ	JJ	_	7	amod	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	Elf-1	elf-1	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	binding	bind	VBG	VBG	_	1	acl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	retinoblastoma	retinoblastoma	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	retinoblastoma	retinoblastoma	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Rb	rb	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	phosphoprotein	phosphoprotein	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	regulates	regulate	VBZ	VBZ	_	11	acl:relcl	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	cycle	cycle	NN	NN	_	16	compound	_	_
16	progression	progression	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	11	punct	_	_

1	Elf-1	elf-1	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	lymphoid-specific	lymphoid-specific	JJ	JJ	_	7	amod	_	_
5	Ets	ets	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	regulates	regulate	VBZ	VBZ	_	7	acl:relcl	_	_
10	inducible	inducible	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	during	during	IN	IN	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	it	it	PRP	PRP	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	Elf-1	elf-1	NN	NN	_	10	nsubj	_	_
10	contains	contain	VBZ	VBZ	_	7	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	sequence	sequence	NN	NN	_	13	compound	_	_
13	motif	motif	NN	NN	_	10	dobj	_	_
14	that	that	WDT	WDT	_	17	nsubj	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	highly	highly	RB	RB	_	17	advmod	_	_
17	related	related	JJ	JJ	_	13	acl:relcl	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	Rb	rb	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	17	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	several	several	JJ	JJ	_	26	amod	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	oncoproteins	oncoprotein	NNS	NNS	_	22	nmod	_	_
27	and	and	CC	CC	_	17	cc	_	_
28	binds	bind	VBZ	VBZ	_	17	conj	_	_
29	to	to	TO	TO	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	pocket	pocket	NN	NN	_	32	compound	_	_
32	region	region	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	Rb	rb	NN	NN	_	32	nmod	_	_
35	both	both	CC	CC	_	38	cc:preconj	_	_
36	in	in	FW	FW	_	37	compound	_	_
37	vitro	vitro	FW	FW	_	38	advmod	_	_
38	and	and	CC	CC	_	28	advmod	_	_
39	in	in	FW	FW	_	40	compound	_	_
40	vivo	vivo	FW	FW	_	38	advmod	_	_
41	.	.	.	.	_	7	punct	_	_

1	Elf-1	elf-1	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	exclusively	exclusively	RB	RB	_	2	advmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	underphosphorylated	underphosphorylated	JJ	JJ	_	7	amod	_	_
7	form	form	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Rb	rb	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	fails	fail	VBZ	VBZ	_	2	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	bind	bind	VB	VB	_	11	xcomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	Rb	rb	NN	NN	_	16	compound	_	_
16	mutants	mutant	NNS	NNS	_	13	nmod	_	_
17	derived	derive	VBN	VBN	_	16	acl	_	_
18	from	from	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	retinoblastoma	retinoblastoma	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Co-immunoprecipitation	co-immunoprecipitation	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	association	association	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	Elf-1	elf-1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Rb	rb	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	15	case	_	_
11	resting	rest	VBG	VBG	_	15	amod	_	_
12	normal	normal	JJ	JJ	_	15	amod	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	phosphorylation	phosphorylation	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Rb	rb	NN	NN	_	7	nmod	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	release	release	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Elf-1	elf-1	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	which	which	WDT	WDT	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	correlated	correlate	VBN	VBN	_	13	acl:relcl	_	_
20	temporally	temporally	RB	RB	_	19	advmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activation	activation	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	Elf-1-mediated	elf-1-mediated	JJ	JJ	_	26	amod	_	_
26	transcription	transcription	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Overexpression	overexpression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	phosphorylation-defective	phosphorylation-defective	JJ	JJ	_	5	amod	_	_
5	form	form	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Rb	rb	NN	NN	_	5	nmod	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	Elf-1-dependent	elf-1-dependent	JJ	JJ	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	8	dobj	_	_
11	during	during	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Rb	rb	NN	NN	_	6	nsubj	_	_
6	interacts	interact	VBZ	VBZ	_	3	ccomp	_	_
7	specifically	specifically	RB	RB	_	6	advmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	a	a	DT	DT	_	13	det	_	_
10	lineage-restricted	lineage-restricted	JJ	JJ	_	13	amod	_	_
11	Ets	ets	NN	NN	_	13	compound	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	regulated	regulated	JJ	JJ	_	3	amod	_	_
3	interaction	interaction	NN	NN	_	6	nsubj	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	important	important	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	coordination	coordination	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	lineage-specific	lineage-specific	JJ	JJ	_	13	amod	_	_
12	effector	effector	NN	NN	_	13	compound	_	_
13	functions	function	NNS	NNS	_	9	nmod	_	_
14	such	such	JJ	JJ	_	17	case	_	_
15	as	as	IN	IN	_	14	mwe	_	_
16	lymphokine	lymphokine	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	13	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	cycle	cycle	NN	NN	_	21	compound	_	_
21	progression	progression	NN	NN	_	9	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	primary	primary	JJ	JJ	_	5	amod	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	T-lymphocytes	t-lymphocyte	NNS	NNS	_	1	nmod	_	_
6	through	through	IN	IN	_	11	case	_	_
7	CD2	cd2	NN	NN	_	11	compound	_	_
8	plus	plus	CC	CC	_	7	cc	_	_
9	CD28	cd28	NN	NN	_	7	conj	_	_
10	adhesion	adhesion	NN	NN	_	11	compound	_	_
11	molecules	molecule	NNS	NNS	_	1	nmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	long-term	long-term	JJ	JJ	_	15	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Stimulation	stimulation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	highly	highly	RB	RB	_	4	advmod	_	_
4	purified	purify	VBN	VBN	_	6	amod	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	T-cells	t-cell	NNS	NNS	_	1	nmod	_	_
7	via	via	IN	IN	_	12	case	_	_
8	CD2	cd2	NN	NN	_	12	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CD28	cd28	NN	NN	_	8	conj	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	1	nmod	_	_
13	induces	induce	VBZ	VBZ	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	maintains	maintain	VBZ	VBZ	_	13	conj	_	_
16	proliferation	proliferation	NN	NN	_	13	dobj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	more	more	JJR	JJR	_	20	advmod	_	_
19	than	than	IN	IN	_	18	mwe	_	_
20	3	3	CD	CD	_	21	nummod	_	_
21	weeks	week	NNS	NNS	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	9	det	_	_
2	potent	potent	JJ	JJ	_	9	amod	_	_
3	interleukin	interleukin	NN	NN	_	8	nmod:npmod	_	_
4	2	2	CD	CD	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	IL-2	il-2	NN	NN	_	8	nmod:npmod	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	-dependent	-dependent	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	12	nsubj	_	_
10	does	do	VBZ	VBZ	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	require	require	VB	VB	_	0	root	_	_
13	monocytes	monocyte	NNS	NNS	_	12	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	accessory	accessory	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	12	punct	_	_

1	Long-lasting	long-lasting	JJ	JJ	_	3	amod	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	receptivity	receptivity	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	high-level	high-level	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	20	case	_	_
10	the	the	DT	DT	_	20	det	_	_
11	inducible	inducible	JJ	JJ	_	20	amod	_	_
12	IL-2	il-2	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	chain	chain	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	IL-2R	il-2r	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	gene	gene	NN	NN	_	8	nmod	_	_
21	that	that	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	regulated	regulate	VBN	VBN	_	8	acl:relcl	_	_
24	at	at	IN	IN	_	29	case	_	_
25	both	both	CC	CC	_	26	cc:preconj	_	_
26	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	posttranscriptional	posttranscriptional	JJ	JJ	_	26	conj	_	_
29	levels	level	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Increase	increase	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	IL-2R	il-2r	NN	NN	_	6	compound	_	_
4	alpha	alpha	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	1	nmod	_	_
7	involves	involve	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	enhanced	enhance	VBN	VBN	_	10	amod	_	_
10	binding	binding	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	transcription	transcription	NN	NN	_	16	compound	_	_
14	factor	factor	NN	NN	_	16	compound	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	10	nmod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	consensus	consensus	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	10	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	5'-regulatory	5'-regulatory	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	IL-2R	il-2r	NN	NN	_	29	compound	_	_
28	alpha	alpha	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	dissect	dissect	VB	VB	_	18	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	unusually	unusually	RB	RB	_	9	advmod	_	_
9	persistent	persistent	JJ	JJ	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	IL-2R	il-2r	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	analyzed	analyze	VBD	VBD	_	0	root	_	_
19	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	dobj	_	_
22	binding	bind	VBG	VBG	_	21	amod	_	_
23	to	to	TO	TO	_	31	case	_	_
24	a	a	DT	DT	_	31	det	_	_
25	radiolabeled	radiolabele	VBN	VBN	_	31	amod	_	_
26	IL-2R	il-2r	NN	NN	_	31	compound	_	_
27	alpha	alpha	NN	NN	_	31	compound	_	_
28	kappa	kappa	NN	NN	_	29	nmod:npmod	_	_
29	B-specific	b-specific	JJ	JJ	_	31	amod	_	_
30	oligonucleotide	oligonucleotide	NN	NN	_	31	compound	_	_
31	probe	probe	NN	NN	_	21	nmod	_	_
32	during	during	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	time	time	NN	NN	_	35	compound	_	_
35	course	course	NN	NN	_	21	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	CD2	cd2	NN	NN	_	40	compound	_	_
38	+	+	CC	CC	_	37	cc	_	_
39	CD28	cd28	NN	NN	_	37	conj	_	_
40	activation	activation	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	18	punct	_	_

1	Resting	rest	VBG	VBG	_	4	amod	_	_
2	T-cell	t-cell	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	extracts	extract	NNS	NNS	_	5	nsubj	_	_
5	contained	contain	VBD	VBD	_	0	root	_	_
6	KBF1/p50	kbf1/p50	NN	NN	_	7	compound	_	_
7	homodimer	homodimer	NN	NN	_	5	dobj	_	_
8	.	.	.	.	_	5	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	two	two	CD	CD	_	8	nummod	_	_
5	new	new	JJ	JJ	_	8	amod	_	_
6	kappa	kappa	NN	NN	_	7	nmod:npmod	_	_
7	B-specific	b-specific	JJ	JJ	_	8	amod	_	_
8	complexes	complex	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	as	as	IN	IN	_	15	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	p50-p65	p50-p65	NN	NN	_	15	compound	_	_
15	heterodimer	heterodimer	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	putative	putative	JJ	JJ	_	19	amod	_	_
18	c-Rel	c-rel	NN	NN	_	19	compound	_	_
19	homodimer	homodimer	NN	NN	_	15	conj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	c-Rel-p65	c-rel-p65	NN	NN	_	22	compound	_	_
22	heterodimer	heterodimer	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	Both	both	DT	DT	_	3	det	_	_
2	inducible	inducible	JJ	JJ	_	3	amod	_	_
3	complexes	complex	NNS	NNS	_	4	nsubj	_	_
4	persisted	persist	VBD	VBD	_	0	root	_	_
5	for	for	IN	IN	_	9	case	_	_
6	at	at	IN	IN	_	7	case	_	_
7	least	least	JJS	JJS	_	8	nmod:npmod	_	_
8	3	3	CD	CD	_	9	nummod	_	_
9	weeks	week	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	relative	relative	JJ	JJ	_	3	amod	_	_
3	levels	level	NNS	NNS	_	6	nsubj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	very	very	RB	RB	_	6	advmod	_	_
6	similar	similar	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	duration	duration	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	proliferation	proliferation	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	CD2	cd2	NN	NN	_	7	compound	_	_
5	+	+	CC	CC	_	4	cc	_	_
6	CD28	cd28	NN	NN	_	4	conj	_	_
7	activation	activation	NN	NN	_	8	nsubj	_	_
8	triggered	trigger	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	13	det	_	_
10	significant	significant	JJ	JJ	_	13	amod	_	_
11	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
12	thiol	thiol	NN	NN	_	13	compound	_	_
13	decrease	decrease	NN	NN	_	8	dobj	_	_
14	,	,	,	,	_	8	punct	_	_
15	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	oxygen	oxygen	NN	NN	_	18	compound	_	_
18	radicals	radical	NNS	NNS	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	15	ccomp	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecules	molecule	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	26	advmod	_	_
2	,	,	,	,	_	26	punct	_	_
3	micromolar	micromolar	JJ	JJ	_	4	amod	_	_
4	amounts	amount	NNS	NNS	_	26	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	pyrrolidine	pyrrolidine	NN	NN	_	7	compound	_	_
7	dithiocarbamate	dithiocarbamate	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	an	a	DT	DT	_	12	det	_	_
10	oxygen	oxygen	NN	NN	_	11	dep	_	_
11	radical	radical	NN	NN	_	12	amod	_	_
12	scavenger	scavenger	NN	NN	_	7	appos	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	efficiently	efficiently	RB	RB	_	15	advmod	_	_
15	blocked	block	VBD	VBD	_	12	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	appearance	appearance	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	T-lymphocytes	t-lymphocyte	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	7	punct	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	inhibited	inhibit	VBD	VBD	_	0	root	_	_
27	IL-2	il-2	NN	NN	_	28	compound	_	_
28	secretion	secretion	NN	NN	_	26	dobj	_	_
29	,	,	,	,	_	28	punct	_	_
30	IL-2R	il-2r	NN	NN	_	34	compound	_	_
31	alpha	alpha	NN	NN	_	34	compound	_	_
32	cell	cell	NN	NN	_	34	compound	_	_
33	surface	surface	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	28	conj	_	_
35	,	,	,	,	_	28	punct	_	_
36	and	and	CC	CC	_	28	cc	_	_
37	T-cell	t-cell	NN	NN	_	38	compound	_	_
38	proliferation	proliferation	NN	NN	_	28	conj	_	_
39	.	.	.	.	_	26	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	nsubj	_	_
9	plays	play	VBZ	VBZ	_	5	ccomp	_	_
10	an	a	DT	DT	_	12	det	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	long-term	long-term	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	primary	primary	JJ	JJ	_	19	amod	_	_
19	T-lymphocytes	t-lymphocyte	NNS	NNS	_	15	nmod	_	_
20	via	via	IN	IN	_	21	case	_	_
21	CD2	cd2	NN	NN	_	15	nmod	_	_
22	+	+	CC	CC	_	21	cc	_	_
23	CD28	cd28	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Oxidoreductive	oxidoreductive	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	cellular	cellular	JJ	JJ	_	7	amod	_	_
5	reducing	reducing	NN	NN	_	7	compound	_	_
6	catalyst	catalyst	NN	NN	_	7	compound	_	_
7	thioredoxin	thioredoxin	NN	NN	_	1	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	7	nsubj	_	_
2	have	have	VBP	VBP	_	7	aux	_	_
3	investigated	investigate	VBN	VBN	_	7	dep	_	_
4	an	a	DT	DT	_	7	det	_	_
5	oxidoreductive	oxidoreductive	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	pathway	pathway	NN	NN	_	0	root	_	_
8	for	for	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	pleiotropic	pleiotropic	JJ	JJ	_	18	amod	_	_
16	cellular	cellular	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
21	factor	factor	NN	NN	_	23	compound	_	_
22	kappa	kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	18	appos	_	_
24	(	(	-LRB-	-LRB-	_	27	punct	_	_
25	NF	nf	NN	NN	_	27	compound	_	_
26	kappa	kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	23	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	18	punct	_	_
30	has	have	VBZ	VBZ	_	7	dep	_	_
31	been	be	VBN	VBN	_	7	cop	_	_
32	investigated	investigate	VBN	VBN	_	7	dep	_	_
33	by	by	IN	IN	_	34	mark	_	_
34	using	use	VBG	VBG	_	7	advcl	_	_
35	NF	nf	NN	NN	_	37	compound	_	_
36	kappa	kappa	NN	NN	_	37	compound	_	_
37	B	b	NN	NN	_	34	dobj	_	_
38	prepared	prepare	VBN	VBN	_	37	acl	_	_
39	from	from	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	nucleus	nucleus	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	the	the	DT	DT	_	44	det	_	_
44	cytosol	cytosol	NN	NN	_	41	conj	_	_
45	of	of	IN	IN	_	50	case	_	_
46	the	the	DT	DT	_	50	det	_	_
47	primary	primary	JJ	JJ	_	50	amod	_	_
48	human	human	JJ	JJ	_	50	amod	_	_
49	T	t	NN	NN	_	50	compound	_	_
50	lymphocytes	lymphocyte	NNS	NNS	_	41	nmod	_	_
51	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	a	a	DT	DT	_	7	det	_	_
5	cellular	cellular	JJ	JJ	_	7	amod	_	_
6	reducing	reducing	NN	NN	_	7	compound	_	_
7	catalyst	catalyst	NN	NN	_	12	nsubj	_	_
8	thioredoxin	thioredoxin	NN	NN	_	7	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Trx	trx	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	plays	play	VBZ	VBZ	_	2	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	major	major	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	binding	binding	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	NF	nf	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	21	nmod	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	21	advmod	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	stimulation	stimulation	NN	NN	_	17	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	transcription	transcription	NN	NN	_	29	nmod	_	_
32	from	from	IN	IN	_	38	case	_	_
33	the	the	DT	DT	_	38	det	_	_
34	NF	nf	NN	NN	_	36	nmod:npmod	_	_
35	kappa	kappa	NN	NN	_	36	nmod:npmod	_	_
36	B-dependent	b-dependent	JJ	JJ	_	38	amod	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	suggesting	suggest	VBG	VBG	_	3	acl	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	redox	redox	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	NF	nf	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Trx	trx	NN	NN	_	7	nmod	_	_
14	might	might	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	exerted	exert	VBN	VBN	_	4	ccomp	_	_
17	at	at	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	step	step	NN	NN	_	16	nmod	_	_
20	after	after	IN	IN	_	21	case	_	_
21	dissociation	dissociation	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	inhibitory	inhibitory	JJ	JJ	_	28	amod	_	_
25	molecule	molecule	NN	NN	_	28	compound	_	_
26	I	i	NN	NN	_	28	compound	_	_
27	kappa	kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	21	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	a	a	DT	DT	_	32	det	_	_
31	cytosolic-anchoring	cytosolic-anchoring	JJ	JJ	_	32	amod	_	_
32	protein	protein	NN	NN	_	28	appos	_	_
33	for	for	IN	IN	_	36	case	_	_
34	NF	nf	NN	NN	_	36	compound	_	_
35	kappa	kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	12	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Trx	trx	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	intact	intact	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	performed	perform	VBD	VBD	_	0	root	_	_
13	transient	transient	JJ	JJ	_	14	amod	_	_
14	assay	assay	NN	NN	_	12	dobj	_	_
15	with	with	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	chloramphenicol	chloramphenicol	NN	NN	_	18	nmod:npmod	_	_
18	acetyltransferase-expressing	acetyltransferase-expressing	JJ	JJ	_	19	amod	_	_
19	plasmid	plasmid	NN	NN	_	12	nmod	_	_
20	under	under	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	control	control	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	32	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	immunodeficiency	immunodeficiency	NN	NN	_	26	compound	_	_
26	virus	virus	NN	NN	_	32	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	HIV	hiv	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	long	long	JJ	JJ	_	32	amod	_	_
31	terminal	terminal	JJ	JJ	_	32	amod	_	_
32	repeat	repeat	NN	NN	_	22	nmod	_	_
33	and	and	CC	CC	_	19	cc	_	_
34	an	a	DT	DT	_	36	det	_	_
35	effector	effector	NN	NN	_	36	compound	_	_
36	plasmid	plasmid	NN	NN	_	19	conj	_	_
37	expressing	express	VBG	VBG	_	36	acl	_	_
38	human	human	JJ	JJ	_	39	amod	_	_
39	Trx	trx	NN	NN	_	37	dobj	_	_
40	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	11	nsubjpass	_	_
4	from	from	IN	IN	_	8	case	_	_
5	HIV	hiv	NN	NN	_	8	compound	_	_
6	long	long	JJ	JJ	_	8	amod	_	_
7	terminal	terminal	JJ	JJ	_	8	amod	_	_
8	repeat	repeat	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	greatly	greatly	RB	RB	_	11	advmod	_	_
11	augmented	augment	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	co-transfecting	co-transfect	VBG	VBG	_	11	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	Trx-expressing	trx-expressing	NN	NN	_	16	compound	_	_
16	plasmid	plasmid	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	whose	whose	WP$	WP$	_	19	nmod:poss	_	_
19	effect	effect	NN	NN	_	21	nsubj	_	_
20	was	be	VBD	VBD	_	21	cop	_	_
21	dependent	dependent	JJ	JJ	_	16	acl:relcl	_	_
22	on	on	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	NF	nf	NN	NN	_	26	dep	_	_
25	kappa	kappa	NN	NN	_	26	dep	_	_
26	B-binding	b-binding	NN	NN	_	27	amod	_	_
27	sites	site	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	cysteine	cysteine	NN	NN	_	9	compound	_	_
7	residue	residue	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	17	nsubjpass	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	of	of	IN	IN	_	14	case	_	_
12	NF	nf	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	might	might	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	involved	involve	VBN	VBN	_	4	ccomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	DNA-recognition	dna-recognition	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	NF	nf	NN	NN	_	24	compound	_	_
23	kappa	kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	that	that	IN	IN	_	35	mark	_	_
27	the	the	DT	DT	_	30	det	_	_
28	redox	redox	NN	NN	_	30	compound	_	_
29	control	control	NN	NN	_	30	compound	_	_
30	mechanism	mechanism	NN	NN	_	35	nsubj	_	_
31	mediated	mediate	VBN	VBN	_	30	acl	_	_
32	by	by	IN	IN	_	33	case	_	_
33	Trx	trx	NN	NN	_	31	nmod	_	_
34	might	might	MD	MD	_	35	aux	_	_
35	have	have	VB	VB	_	17	conj	_	_
36	a	a	DT	DT	_	38	det	_	_
37	regulatory	regulatory	JJ	JJ	_	38	amod	_	_
38	role	role	NN	NN	_	35	dobj	_	_
39	in	in	IN	IN	_	45	case	_	_
40	the	the	DT	DT	_	45	det	_	_
41	NF	nf	NN	NN	_	43	nmod:npmod	_	_
42	kappa	kappa	NN	NN	_	43	nmod:npmod	_	_
43	B-mediated	b-mediated	JJ	JJ	_	45	amod	_	_
44	gene	gene	NN	NN	_	45	compound	_	_
45	expression	expression	NN	NN	_	35	nmod	_	_
46	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	may	may	MD	MD	_	5	aux	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	provide	provide	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	clue	clue	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	case	_	_
9	understanding	understanding	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	process	process	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	AIDS	aids	NN	NN	_	16	compound	_	_
16	pathogenesis	pathogenesis	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
19	possible	possible	JJ	JJ	_	21	amod	_	_
20	biochemical	biochemical	JJ	JJ	_	21	amod	_	_
21	intervention	intervention	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	thyrotropin	thyrotropin	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	autoimmune	autoimmune	JJ	JJ	_	11	amod	_	_
10	thyroid	thyroid	NN	NN	_	11	compound	_	_
11	disease	disease	NN	NN	_	2	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	coregulation	coregulation	NN	NN	_	2	dep	_	_
14	with	with	IN	IN	_	15	case	_	_
15	parameters	parameter	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	thyroid	thyroid	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	inverse	inverse	JJ	JJ	_	21	amod	_	_
21	relation	relation	NN	NN	_	13	conj	_	_
22	to	to	TO	TO	_	26	case	_	_
23	major	major	JJ	JJ	_	26	amod	_	_
24	histocompatibility	histocompatibility	NN	NN	_	26	compound	_	_
25	complex	complex	NN	NN	_	26	compound	_	_
26	classes	class	NNS	NNS	_	21	nmod	_	_
27	I	i	CD	CD	_	26	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	II	ii	CD	CD	_	27	conj	_	_
30	.	.	.	.	_	13	punct	_	_

1	Using	use	VBG	VBG	_	13	advcl	_	_
2	a	a	DT	DT	_	10	det	_	_
3	human	human	JJ	JJ	_	10	amod	_	_
4	TSH	tsh	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TSH-R	tsh-r	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	cDNA	cdna	NN	NN	_	10	compound	_	_
10	probe	probe	NN	NN	_	1	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	investigated	investigate	VBD	VBD	_	0	root	_	_
14	TSH-R	tsh-r	NN	NN	_	16	compound	_	_
15	transcript	transcript	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	13	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	13	13	CD	CD	_	21	nummod	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	thyroid	thyroid	NN	NN	_	21	compound	_	_
21	fragments	fragment	NNS	NNS	_	16	nmod	_	_
22	by	by	IN	IN	_	25	case	_	_
23	Northern	northern	NN	NN	_	25	compound	_	_
24	blot	blot	NN	NN	_	25	compound	_	_
25	analysis	analysis	NN	NN	_	13	nmod	_	_
26	;	;	:	:	_	13	punct	_	_
27	7	7	CD	CD	_	30	nummod	_	_
28	Graves	graves	NN	NN	_	30	nmod:poss	_	_
29	'	'	POS	POS	_	28	case	_	_
30	disease	disease	NN	NN	_	47	nsubjpass	_	_
31	,	,	,	,	_	30	punct	_	_
32	2	2	CD	CD	_	35	nummod	_	_
33	Hashimoto	hashimoto	NN	NN	_	35	nmod:poss	_	_
34	's	's	POS	POS	_	33	case	_	_
35	disease	disease	NN	NN	_	30	conj	_	_
36	,	,	,	,	_	30	punct	_	_
37	3	3	CD	CD	_	39	nummod	_	_
38	endemic	endemic	JJ	JJ	_	39	amod	_	_
39	goiter	goiter	NN	NN	_	30	conj	_	_
40	,	,	,	,	_	30	punct	_	_
41	and	and	CC	CC	_	30	cc	_	_
42	1	1	CD	CD	_	45	nummod	_	_
43	healthy	healthy	JJ	JJ	_	45	amod	_	_
44	thyroid	thyroid	NN	NN	_	45	compound	_	_
45	gland	gland	NN	NN	_	30	conj	_	_
46	were	be	VBD	VBD	_	47	auxpass	_	_
47	studied	study	VBN	VBN	_	13	parataxis	_	_
48	.	.	.	.	_	47	punct	_	_

1	TSH-R	tsh-r	NN	NN	_	3	compound	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	variable	variable	JJ	JJ	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	5	cc	_	_
8	displayed	display	VBD	VBD	_	5	conj	_	_
9	a	a	DT	DT	_	11	det	_	_
10	close	close	JJ	JJ	_	11	amod	_	_
11	correlation	correlation	NN	NN	_	8	dobj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	thyroid	thyroid	NN	NN	_	17	compound	_	_
17	peroxidase	peroxidase	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	r	r	NN	NN	_	20	nsubj	_	_
20	=	=	JJ	JJ	_	17	dep	_	_
21	0.703	0.703	CD	CD	_	20	dobj	_	_
22	;	;	:	:	_	20	punct	_	_
23	P	p	NN	NN	_	25	dep	_	_
24	&lt;	&lt;	JJR	JJR	_	25	advmod	_	_
25	0.05	0.05	CD	CD	_	20	parataxis	_	_
26	)	)	-RRB-	-RRB-	_	20	punct	_	_
27	,	,	,	,	_	17	punct	_	_
28	thyroglobulin	thyroglobulin	NN	NN	_	17	conj	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	r	r	NN	NN	_	31	nsubj	_	_
31	=	=	JJ	JJ	_	28	dep	_	_
32	0.817	0.817	CD	CD	_	31	dobj	_	_
33	;	;	:	:	_	31	punct	_	_
34	P	p	NN	NN	_	36	dep	_	_
35	&lt;	&lt;	JJR	JJR	_	36	advmod	_	_
36	0.01	0.01	CD	CD	_	31	parataxis	_	_
37	)	)	-RRB-	-RRB-	_	31	punct	_	_
38	,	,	,	,	_	17	punct	_	_
39	and	and	CC	CC	_	17	cc	_	_
40	the	the	DT	DT	_	43	det	_	_
41	nuclear	nuclear	JJ	JJ	_	43	amod	_	_
42	oncogene	oncogene	NN	NN	_	43	compound	_	_
43	c-fos	c-fos	NN	NN	_	17	conj	_	_
44	(	(	-LRB-	-LRB-	_	46	punct	_	_
45	r	r	NN	NN	_	46	nsubj	_	_
46	=	=	JJ	JJ	_	43	dep	_	_
47	0.935	0.935	CD	CD	_	46	dobj	_	_
48	;	;	:	:	_	46	punct	_	_
49	P	p	NN	NN	_	51	dep	_	_
50	&lt;	&lt;	JJR	JJR	_	51	advmod	_	_
51	0.001	0.001	CD	CD	_	46	parataxis	_	_
52	)	)	-RRB-	-RRB-	_	46	punct	_	_
53	,	,	,	,	_	17	punct	_	_
54	but	but	CC	CC	_	55	cc	_	_
55	not	not	RB	RB	_	17	cc	_	_
56	c-myc	c-myc	NN	NN	_	17	conj	_	_
57	.	.	.	.	_	5	punct	_	_

1	Overall	overall	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	TSH-R	tsh-r	NN	NN	_	5	compound	_	_
4	transcript	transcript	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	7	nsubj	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	low	low	JJ	JJ	_	0	root	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	absent	absent	JJ	JJ	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	those	those	DT	DT	_	12	det	_	_
12	thyroids	thyroid	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	32	nmod	_	_
15	expression	expression	NN	NN	_	32	nsubj	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	major	major	JJ	JJ	_	21	amod	_	_
19	histocompatibility	histocompatibility	NN	NN	_	21	compound	_	_
20	complex	complex	NN	NN	_	21	compound	_	_
21	class	class	NN	NN	_	15	nmod	_	_
22	I	i	CD	CD	_	21	dep	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	II	ii	CD	CD	_	22	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MHC	mhc	NN	NN	_	21	appos	_	_
27	I	i	CD	CD	_	26	dep	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	II	ii	CD	CD	_	27	conj	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	was	be	VBD	VBD	_	32	cop	_	_
32	high	high	JJ	JJ	_	12	acl:relcl	_	_
33	,	,	,	,	_	7	punct	_	_
34	thus	thus	RB	RB	_	35	advmod	_	_
35	establishing	establish	VBG	VBG	_	7	xcomp	_	_
36	an	a	DT	DT	_	38	det	_	_
37	inverse	inverse	JJ	JJ	_	38	amod	_	_
38	relation	relation	NN	NN	_	35	dobj	_	_
39	(	(	-LRB-	-LRB-	_	44	punct	_	_
40	MHC	mhc	NN	NN	_	41	dep	_	_
41	I	i	NN	NN	_	44	dep	_	_
42	,	,	,	,	_	44	punct	_	_
43	r	r	NN	NN	_	44	nsubj	_	_
44	=	=	JJ	JJ	_	7	dep	_	_
45	-0.791	-0.791	CD	CD	_	44	dobj	_	_
46	;	;	:	:	_	44	punct	_	_
47	P	p	NN	NN	_	49	dep	_	_
48	&lt;	&lt;	JJR	JJR	_	49	advmod	_	_
49	0.01	0.01	CD	CD	_	44	parataxis	_	_
50	;	;	:	:	_	44	punct	_	_
51	MHC	mhc	NN	NN	_	52	dep	_	_
52	II	ii	CD	CD	_	55	dep	_	_
53	,	,	,	,	_	55	punct	_	_
54	r	r	NN	NN	_	55	nsubj	_	_
55	=	=	JJ	JJ	_	44	dep	_	_
56	-0.784	-0.784	NN	NN	_	55	dobj	_	_
57	;	;	:	:	_	55	punct	_	_
58	P	p	NN	NN	_	60	dep	_	_
59	&lt;	&lt;	JJR	JJR	_	60	advmod	_	_
60	0.01	0.01	CD	CD	_	55	parataxis	_	_
61	)	)	-RRB-	-RRB-	_	44	punct	_	_
62	.	.	.	.	_	7	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	hybridization	hybridization	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	apart	apart	RB	RB	_	8	advmod	_	_
7	from	from	IN	IN	_	8	case	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	thyroid	thyroid	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	15	nsubj	_	_
12	themselves	themselves	PRP	PRP	_	11	nmod:npmod	_	_
13	were	be	VBD	VBD	_	15	cop	_	_
14	the	the	DT	DT	_	15	det	_	_
15	source	source	NN	NN	_	4	ccomp	_	_
16	of	of	IN	IN	_	19	case	_	_
17	MHC	mhc	NN	NN	_	19	compound	_	_
18	II	ii	CD	CD	_	19	nummod	_	_
19	transcripts	transcript	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	gamma-Interferon	gamma-interferon	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	only	only	RB	RB	_	5	advmod	_	_
5	detectable	detectable	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	1	1	CD	CD	_	10	nummod	_	_
8	Hashimoto	hashimoto	NN	NN	_	10	nmod:poss	_	_
9	's	's	POS	POS	_	8	case	_	_
10	goiter	goiter	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	next	next	JJ	JJ	_	17	advmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	infiltration	infiltration	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	active	active	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	events	event	NNS	NNS	_	17	nsubj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	thyrocyte	thyrocyte	NN	NN	_	12	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
18	for	for	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	inverse	inverse	JJ	JJ	_	21	amod	_	_
21	relation	relation	NN	NN	_	17	nmod	_	_
22	between	between	IN	IN	_	24	case	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	parameters	parameter	NNS	NNS	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TSH-R	tsh-r	NN	NN	_	24	dep	_	_
27	,	,	,	,	_	26	punct	_	_
28	thyroid	thyroid	NN	NN	_	29	compound	_	_
29	peroxidase	peroxidase	NN	NN	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	thyroglobulin	thyroglobulin	NN	NN	_	26	conj	_	_
32	,	,	,	,	_	26	punct	_	_
33	and	and	CC	CC	_	26	cc	_	_
34	c-fos	c-fos	NN	NN	_	26	conj	_	_
35	)	)	-RRB-	-RRB-	_	26	punct	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	immunological	immunological	JJ	JJ	_	38	amod	_	_
38	markers	marker	NNS	NNS	_	24	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	MHC	mhc	NN	NN	_	38	appos	_	_
41	I	i	CD	CD	_	40	dep	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	II	ii	CD	CD	_	41	conj	_	_
44	)	)	-RRB-	-RRB-	_	40	punct	_	_
45	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	17	nsubjpass	_	_
2	of	of	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	interleukin-1	interleukin-1	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	IL-1	il-1	NN	NN	_	8	compound	_	_
8	beta	beta	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	gene	gene	NN	NN	_	1	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	mycobacterial	mycobacterial	JJ	JJ	_	13	amod	_	_
13	components	component	NNS	NNS	_	1	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	13	conj	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	22	case	_	_
19	two	two	CD	CD	_	22	nummod	_	_
20	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
21	factor-IL6	factor-il6	JJ	JJ	_	22	amod	_	_
22	motifs	motif	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	18	nsubjpass	_	_
3	interleukin-1	interleukin-1	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	2	dep	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	IL-1	il-1	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	tumor	tumor	NN	NN	_	13	compound	_	_
11	necrosis	necrosis	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	4	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	released	release	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	21	case	_	_
20	mononuclear	mononuclear	JJ	JJ	_	21	amod	_	_
21	phagocytes	phagocyte	NNS	NNS	_	18	nmod	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	18	advmod	_	_
24	after	after	IN	IN	_	25	case	_	_
25	stimulation	stimulation	NN	NN	_	18	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	mycobacteria	mycobacterium	NNS	NNS	_	25	nmod	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	are	be	VBP	VBP	_	30	auxpass	_	_
30	considered	consider	VBN	VBN	_	18	conj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	mediate	mediate	VB	VB	_	30	xcomp	_	_
33	pathophysiologic	pathophysiologic	JJ	JJ	_	34	amod	_	_
34	events	event	NNS	NNS	_	32	dobj	_	_
35	,	,	,	,	_	34	punct	_	_
36	including	include	VBG	VBG	_	38	case	_	_
37	granuloma	granuloma	NN	NN	_	38	compound	_	_
38	formation	formation	NN	NN	_	34	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	systemic	systemic	JJ	JJ	_	41	amod	_	_
41	symptoms	symptom	NNS	NNS	_	38	conj	_	_
42	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	the	the	DT	DT	_	9	det	_	_
5	Mycobacterium	mycobacterium	NN	NN	_	9	compound	_	_
6	tuberculosis	tuberculosis	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	wall	wall	NN	NN	_	9	compound	_	_
9	component	component	NN	NN	_	18	nsubj	_	_
10	lipoarabinomannan	lipoarabinomannan	NN	NN	_	9	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	LAM	lam	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	18	cop	_	_
15	a	a	DT	DT	_	18	det	_	_
16	very	very	RB	RB	_	17	advmod	_	_
17	potent	potent	JJ	JJ	_	18	amod	_	_
18	inducer	inducer	NN	NN	_	2	ccomp	_	_
19	of	of	IN	IN	_	23	case	_	_
20	IL-1	il-1	NN	NN	_	23	compound	_	_
21	beta	beta	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	2	cc	_	_
28	investigated	investigate	VBD	VBD	_	2	conj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	mechanism	mechanism	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	effect	effect	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	localized	localize	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	15	det	_	_
4	LAM-	lam-	NN	NN	_	15	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	lipopolysaccharide	lipopolysaccharide	NN	NN	_	4	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	LPS	lps	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	-	-	:	:	_	6	punct	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	TNF-alpha-inducible	tnf-alpha-inducible	JJ	JJ	_	4	conj	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	2	dobj	_	_
16	to	to	TO	TO	_	26	case	_	_
17	a	a	DT	DT	_	26	det	_	_
18	-131/+15	-131/+15	CD	CD	_	26	amod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	positions	position	NNS	NNS	_	18	dep	_	_
21	-131	-131	CD	CD	_	20	dep	_	_
22	to	to	TO	TO	_	21	dep	_	_
23	+15	+15	CD	CD	_	21	dep	_	_
24	)	)	-RRB-	-RRB-	_	20	punct	_	_
25	DNA	dna	NN	NN	_	26	compound	_	_
26	fragment	fragment	NN	NN	_	2	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	IL-1	il-1	NN	NN	_	31	compound	_	_
30	beta	beta	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	26	nmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	deletion	deletion	NN	NN	_	34	compound	_	_
34	analysis	analysis	NN	NN	_	2	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	chloramphenicol	chloramphenicol	NN	NN	_	38	compound	_	_
37	acetyltransferase	acetyltransferase	NN	NN	_	38	compound	_	_
38	assay	assay	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	2	punct	_	_

1	Within	within	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	fragment	fragment	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	there	there	EX	EX	_	7	expl	_	_
7	were	be	VBD	VBD	_	0	root	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	novel	novel	JJ	JJ	_	11	amod	_	_
10	9-bp	9-bp	JJ	JJ	_	11	amod	_	_
11	motifs	motif	NNS	NNS	_	7	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	-90/-82	-90/-82	CD	CD	_	11	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-40/-32	-40/-32	CD	CD	_	13	conj	_	_
16	)	)	-RRB-	-RRB-	_	13	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	high	high	JJ	JJ	_	19	amod	_	_
19	homology	homology	NN	NN	_	11	nmod	_	_
20	to	to	TO	TO	_	28	case	_	_
21	the	the	DT	DT	_	28	det	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	factor-IL6	factor-il6	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	NF-IL6	nf-il6	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	19	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	two	two	CD	CD	_	8	nummod	_	_
7	NF-IL-6	nf-il-6	NN	NN	_	8	compound	_	_
8	motifs	motif	NNS	NNS	_	12	nsubjpass	_	_
9	could	could	MD	MD	_	12	aux	_	_
10	be	be	VB	VB	_	12	auxpass	_	_
11	independently	independently	RB	RB	_	12	advmod	_	_
12	activated	activate	VBN	VBN	_	3	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	LAM	lam	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	LPS	lps	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	or	or	CC	CC	_	14	cc	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	14	conj	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	that	that	IN	IN	_	23	mark	_	_
22	they	they	PRP	PRP	_	23	nsubj	_	_
23	acted	act	VBD	VBD	_	12	conj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	an	a	DT	DT	_	27	det	_	_
26	orientation-independent	orientation-independent	JJ	JJ	_	27	amod	_	_
27	manner	manner	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	DNA	dna	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	specific	specific	JJ	JJ	_	7	amod	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	s	s	NNS	NNS	_	7	nmod	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	from	from	IN	IN	_	22	case	_	_
15	LAM-	lam-	NN	NN	_	22	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	LPS-	lps-	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	or	or	CC	CC	_	15	cc	_	_
20	TNF-alpha-stimulated	tnf-alpha-stimulated	JJ	JJ	_	15	conj	_	_
21	THP-1	thp-1	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	12	nmod	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	NF-IL6	nf-il6	NN	NN	_	26	compound	_	_
26	motifs	motif	NNS	NNS	_	7	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	NF-IL6	nf-il6	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	8	nsubj	_	_
8	mediate	mediate	VBP	VBP	_	2	ccomp	_	_
9	induction	induction	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-1	il-1	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	response	response	NN	NN	_	17	dep	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	stimuli	stimulus	NNS	NNS	_	8	nmod	_	_
18	LAM	lam	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	LPS	lps	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Synergism	synergism	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	CD3	cd3	NN	NN	_	5	compound	_	_
5	antigen-	antigen-	NN	NN	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CD2	cd2	NN	NN	_	8	nmod:npmod	_	_
8	antigen-derived	antigen-derived	JJ	JJ	_	5	conj	_	_
9	signals	signal	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Exploration	exploration	NN	NN	_	0	root	_	_
2	at	at	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	level	level	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	induction	induction	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	characterization	characterization	NN	NN	_	1	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	cyclosporine	cyclosporine	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	earlier	earlier	RBR	RBR	_	3	advmod	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	crosslinkage	crosslinkage	NN	NN	_	16	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CD3/TCR	cd3/tcr	NN	NN	_	11	compound	_	_
11	complex	complex	NN	NN	_	7	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CD2	cd2	NN	NN	_	15	compound	_	_
15	antigen	antigen	NN	NN	_	7	nmod	_	_
16	results	result	VBZ	VBZ	_	3	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	proliferation	proliferation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	normal	normal	JJ	JJ	_	24	amod	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	synergism	synergism	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	perceptible	perceptible	JJ	JJ	_	0	root	_	_
8	at	at	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	level	level	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	induction	induction	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	process	process	NN	NN	_	12	appos	_	_
20	critical	critical	JJ	JJ	_	19	amod	_	_
21	for	for	IN	IN	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	growth	growth	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	understand	understand	VB	VB	_	15	advcl	_	_
4	the	the	DT	DT	_	8	det	_	_
5	molecular	molecular	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	nuclear	nuclear	JJ	JJ	_	5	conj	_	_
8	basis	basis	NN	NN	_	3	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	synergism	synergism	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	explored	explore	VBN	VBN	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	27	case	_	_
22	highly	highly	RB	RB	_	23	advmod	_	_
23	purified	purify	VBN	VBN	_	27	amod	_	_
24	normal	normal	JJ	JJ	_	27	amod	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	17	nmod	_	_
28	signaled	signal	VBN	VBN	_	27	acl	_	_
29	via	via	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	CD3	cd3	NN	NN	_	34	compound	_	_
32	and/or	and/or	CC	CC	_	31	cc	_	_
33	CD2	cd2	NN	NN	_	31	conj	_	_
34	proteins	protein	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transmembrane	transmembrane	NN	NN	_	5	compound	_	_
5	signaling	signaling	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	ionomycin	ionomycin	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	and/or	and/or	CC	CC	_	10	cc	_	_
13	sn-1,2	sn-1,2	NN	NN	_	15	compound	_	_
14	dioctanoyl	dioctanoyl	NN	NN	_	15	compound	_	_
15	glycerol	glycerol	NN	NN	_	10	conj	_	_
16	,	,	,	,	_	10	punct	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	determined	determine	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	emergence	emergence	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	using	use	VBG	VBG	_	8	xcomp	_	_
10	interleukin-2	interleukin-2	NN	NN	_	12	nmod:npmod	_	_
11	sequence	sequence	NN	NN	_	12	nmod:npmod	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	oligonucleotide	oligonucleotide	NN	NN	_	14	compound	_	_
14	probes	probe	NNS	NNS	_	9	dobj	_	_
15	in	in	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	electrophoretic	electrophoretic	JJ	JJ	_	20	amod	_	_
18	mobility	mobility	NN	NN	_	20	compound	_	_
19	shift	shift	NN	NN	_	20	compound	_	_
20	assay	assay	NN	NN	_	9	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	CD3	cd3	NN	NN	_	10	nmod:npmod	_	_
10	antigen-derived	antigen-derived	JJ	JJ	_	11	amod	_	_
11	signals	signal	NNS	NNS	_	17	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CD2	cd2	NN	NN	_	14	nmod:npmod	_	_
14	antigen-derived	antigen-derived	JJ	JJ	_	15	amod	_	_
15	signals	signal	NNS	NNS	_	11	conj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	synergistic	synergistic	JJ	JJ	_	3	ccomp	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	inducing	induce	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	emergence	emergence	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	bind	bind	VBP	VBP	_	24	acl:relcl	_	_
27	to	to	TO	TO	_	35	case	_	_
28	the	the	DT	DT	_	35	det	_	_
29	NF-AT1	nf-at1	NN	NN	_	35	compound	_	_
30	,	,	,	,	_	29	punct	_	_
31	AP-1	ap-1	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	NF-kB	nf-kb	NN	NN	_	29	conj	_	_
35	sites	site	NNS	NNS	_	26	nmod	_	_
36	located	located	JJ	JJ	_	35	amod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	promoter/enhancer	promoter/enhancer	NN	NN	_	40	compound	_	_
40	region	region	NN	NN	_	36	nmod	_	_
41	of	of	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	IL-2	il-2	NN	NN	_	44	compound	_	_
44	gene	gene	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	cyclosporine	cyclosporine	NN	NN	_	14	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	at	at	IN	IN	_	6	case	_	_
6	concentrations	concentration	NNS	NNS	_	3	nmod	_	_
7	readily	readily	RB	RB	_	8	advmod	_	_
8	accomplished	accomplish	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	practice	practice	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	inhibit	inhibit	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	emergence	emergence	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	these	these	DT	DT	_	22	det	_	_
21	DNA-binding	dna-binding	JJ	JJ	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	18	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	normal	normal	JJ	JJ	_	27	amod	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	18	nmod	_	_
28	signaled	signal	VBN	VBN	_	27	acl	_	_
29	via	via	IN	IN	_	32	case	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	surface	surface	NN	NN	_	32	compound	_	_
32	proteins	protein	NNS	NNS	_	28	nmod	_	_
33	implicated	implicate	VBN	VBN	_	32	acl	_	_
34	in	in	IN	IN	_	38	case	_	_
35	antigen-dependent	antigen-dependent	JJ	JJ	_	38	amod	_	_
36	T	t	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	activation	activation	NN	NN	_	33	nmod	_	_
39	and	and	CC	CC	_	27	cc	_	_
40	in	in	IN	IN	_	42	case	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	27	conj	_	_
43	stimulated	stimulate	VBN	VBN	_	42	acl	_	_
44	by	by	IN	IN	_	45	case	_	_
45	mobilization	mobilization	NN	NN	_	43	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	cellular	cellular	JJ	JJ	_	48	amod	_	_
48	calcium	calcium	NN	NN	_	45	nmod	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	activation	activation	NN	NN	_	45	conj	_	_
51	of	of	IN	IN	_	54	case	_	_
52	protein	protein	NN	NN	_	54	compound	_	_
53	kinase	kinase	NN	NN	_	54	compound	_	_
54	C	c	NN	NN	_	50	nmod	_	_
55	.	.	.	.	_	14	punct	_	_

1	Calcium	calcium	NN	NN	_	2	nmod:npmod	_	_
2	dependent	dependent	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NF-AT	nf-at	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	3	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	p59fyn	p59fyn	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	reporter	reporter	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	14	nsubjpass	_	_
4	under	under	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	control	control	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	T-cell	t-cell	NN	NN	_	12	compound	_	_
10	antigen	antigen	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	6	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	activated	activate	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	antigen	antigen	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	triggering	triggering	NN	NN	_	14	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	by	by	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	combination	combination	NN	NN	_	21	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	myristate	myristate	NN	NN	_	29	compound	_	_
29	acetate	acetate	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	activates	activate	VBZ	VBZ	_	29	acl:relcl	_	_
33	protein	protein	NN	NN	_	35	compound	_	_
34	kinase	kinase	NN	NN	_	35	compound	_	_
35	C	c	NN	NN	_	32	dobj	_	_
36	,	,	,	,	_	29	punct	_	_
37	and	and	CC	CC	_	29	cc	_	_
38	a	a	DT	DT	_	40	det	_	_
39	calcium	calcium	NN	NN	_	40	compound	_	_
40	ionophore	ionophore	NN	NN	_	29	conj	_	_
41	.	.	.	.	_	14	punct	_	_

1	Both	both	DT	DT	_	3	det:predet	_	_
2	these	these	DT	DT	_	3	det	_	_
3	signals	signal	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	necessary	necessary	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	expression	expression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	reporter	reporter	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	co-transfected	co-transfect	VBN	VBN	_	18	advcl	_	_
3	with	with	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	construct	construct	NN	NN	_	2	nmod	_	_
6	capable	capable	JJ	JJ	_	5	amod	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	overexpressing	overexpress	VBG	VBG	_	6	advcl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	p59fyn	p59fyn	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	18	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	20	case	_	_
20	PMA	pma	NN	NN	_	18	nmod	_	_
21	alone	alone	RB	RB	_	20	advmod	_	_
22	.	.	.	.	_	18	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	p59fyn	p59fyn	NN	NN	_	4	nsubj	_	_
3	could	could	MD	MD	_	4	aux	_	_
4	replace	replace	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	ionophore	ionophore	NN	NN	_	4	dobj	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	7	cc	_	_
10	activation	activation	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	C	c	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	8	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	p59fyn	p59fyn	NN	NN	_	2	nmod	_	_
5	plus	plus	CC	CC	_	4	cc	_	_
6	PMA	pma	NN	NN	_	4	conj	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	blocked	block	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	EGTA	egta	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	immunosuppressant	immunosuppressant	JJ	JJ	_	17	amod	_	_
15	drug	drug	NN	NN	_	17	compound	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	10	conj	_	_
18	.	.	.	.	_	8	punct	_	_

1	Cell-specific	cell-specific	JJ	JJ	_	3	amod	_	_
2	bifunctional	bifunctional	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	Jun	jun	NN	NN	_	8	compound	_	_
6	oncogene	oncogene	NN	NN	_	8	compound	_	_
7	family	family	NN	NN	_	8	compound	_	_
8	members	member	NNS	NNS	_	3	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	nmod:npmod	_	_
11	receptor-dependent	receptor-dependent	JJ	JJ	_	12	amod	_	_
12	transcription	transcription	NN	NN	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Interaction	interaction	NN	NN	_	19	nsubjpass	_	_
2	between	between	IN	IN	_	17	case	_	_
3	protein	protein	NN	NN	_	7	compound	_	_
4	kinase	kinase	NN	NN	_	7	compound	_	_
5	C	c	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PKC	pkc	NN	NN	_	17	amod	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	-	-	:	:	_	7	punct	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	16	nmod:npmod	_	_
12	receptor	receptor	NN	NN	_	16	nmod:npmod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	GR	gr	NN	NN	_	16	nmod:npmod	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	-mediated	-mediated	JJ	JJ	_	7	conj	_	_
17	signaling	signaling	NN	NN	_	1	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	suggested	suggest	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	ability	ability	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	PKC	pkc	NN	NN	_	28	compound	_	_
26	activating	activating	NN	NN	_	28	compound	_	_
27	phorbol	phorbol	NN	NN	_	28	compound	_	_
28	ester	ester	NN	NN	_	22	nmod	_	_
29	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	28	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	TPA	tpa	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	inhibit	inhibit	VB	VB	_	22	acl	_	_
35	GR-dependent	gr-dependent	JJ	JJ	_	36	amod	_	_
36	transcription	transcription	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	mouse	mouse	NN	NN	_	42	compound	_	_
40	mammary	mammary	JJ	JJ	_	42	amod	_	_
41	tumor	tumor	NN	NN	_	42	compound	_	_
42	virus	virus	NN	NN	_	36	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	MMTV	mmtv	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	long	long	JJ	JJ	_	48	amod	_	_
47	terminal	terminal	JJ	JJ	_	48	amod	_	_
48	repeat	repeat	NN	NN	_	42	dep	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	LTR	ltr	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	19	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	interference	interference	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	cell	cell	NN	NN	_	9	nmod:npmod	_	_
9	specific	specific	JJ	JJ	_	3	ccomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	as	as	IN	IN	_	13	mark	_	_
12	TPA	tpa	NN	NN	_	13	nsubj	_	_
13	augmented	augment	VBD	VBD	_	9	advcl	_	_
14	dexamethasone-induced	dexamethasone-induced	JJ	JJ	_	16	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	MMTV	mmtv	NN	NN	_	20	compound	_	_
20	LTR	ltr	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	several	several	JJ	JJ	_	25	amod	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	13	nmod	_	_
26	but	but	CC	CC	_	13	cc	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	inhibitory	inhibitory	JJ	JJ	_	13	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	NIH-3T3	nih-3t3	NN	NN	_	31	compound	_	_
31	fibroblasts	fibroblast	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	TPA-GR	tpa-gr	NN	NN	_	2	compound	_	_
2	synergism	synergism	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	have	have	VB	VB	_	7	aux	_	_
7	occurred	occur	VBN	VBN	_	4	xcomp	_	_
8	at	at	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	GR-responsive	gr-responsive	JJ	JJ	_	11	amod	_	_
11	element	element	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	GRE	gre	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	level	level	NN	NN	_	7	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	functional	functional	JJ	JJ	_	18	amod	_	_
18	analysis	analysis	NN	NN	_	4	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	deletion	deletion	NN	NN	_	21	compound	_	_
21	mutants	mutant	NNS	NNS	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	synthetic	synthetic	JJ	JJ	_	25	amod	_	_
24	GRE	gre	NN	NN	_	25	compound	_	_
25	oligonucleotides	oligonucleotide	NNS	NNS	_	21	conj	_	_
26	driving	drive	VBG	VBG	_	21	acl	_	_
27	chloramphenicol	chloramphenicol	NN	NN	_	29	compound	_	_
28	acetyl-transferase	acetyl-transferase	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Synergism	synergism	NN	NN	_	2	nsubj	_	_
2	required	require	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	7	det	_	_
4	intact	intact	JJ	JJ	_	7	amod	_	_
5	GR	gr	NN	NN	_	7	compound	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	2	punct	_	_
9	whereas	whereas	IN	IN	_	2	dep	_	_
10	amino-	amino-	NN	NN	_	13	amod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	10	conj	_	_
13	domains	domain	NNS	NNS	_	15	nsubj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	dispensable	dispensable	JJ	JJ	_	2	parataxis	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	abrogated	abrogate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	PKC	pkc	NN	NN	_	9	compound	_	_
8	inhibitor	inhibitor	NN	NN	_	9	compound	_	_
9	staurosporine	staurosporine	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	suggesting	suggest	VBG	VBG	_	4	xcomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	PKC	pkc	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Increased	increase	VBN	VBN	_	8	amod	_	_
2	c-jun	c-jun	NN	NN	_	8	compound	_	_
3	,	,	,	,	_	2	punct	_	_
4	jun-B	jun-b	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	jun-D	jun-d	NN	NN	_	2	conj	_	_
8	expression	expression	NN	NN	_	26	nsubjpass	_	_
9	above	above	IN	IN	_	11	case	_	_
10	basal	basal	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	increased	increase	VBN	VBN	_	15	amod	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	AP-1/TPA	ap-1/tpa	NN	NN	_	19	compound	_	_
18	responsive	responsive	JJ	JJ	_	19	amod	_	_
19	elements	element	NNS	NNS	_	15	nmod	_	_
20	fused	fuse	VBN	VBN	_	19	acl	_	_
21	to	to	TO	TO	_	24	case	_	_
22	chloramphenicol	chloramphenicol	NN	NN	_	24	compound	_	_
23	acetyl-transferase	acetyl-transferase	NN	NN	_	24	compound	_	_
24	vectors	vector	NNS	NNS	_	20	nmod	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	observed	observe	VBN	VBN	_	0	root	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	treated	treat	VBN	VBN	_	29	acl	_	_
31	with	with	IN	IN	_	32	case	_	_
32	TPA	tpa	NN	NN	_	30	nmod	_	_
33	alone	alone	RB	RB	_	34	advmod	_	_
34	or	or	CC	CC	_	32	advmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	combination	combination	NN	NN	_	34	conj	_	_
37	with	with	IN	IN	_	38	case	_	_
38	dexamethasone	dexamethasone	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Jun	jun	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	cooperate	cooperate	VB	VB	_	2	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	GR	gr	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	investigated	investigate	VBN	VBN	_	0	root	_	_
16	after	after	IN	IN	_	17	case	_	_
17	transfection	transfection	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	26	case	_	_
19	c-jun	c-jun	NN	NN	_	26	compound	_	_
20	,	,	,	,	_	19	punct	_	_
21	jun-B	jun-b	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	or	or	CC	CC	_	19	cc	_	_
24	jun-D	jun-d	NN	NN	_	19	conj	_	_
25	expression	expression	NN	NN	_	26	compound	_	_
26	vectors	vector	NNS	NNS	_	17	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	augmented	augment	VBD	VBD	_	17	acl:relcl	_	_
30	GR-dependent	gr-dependent	JJ	JJ	_	31	amod	_	_
31	transcription	transcription	NN	NN	_	29	dobj	_	_
32	from	from	IN	IN	_	35	case	_	_
33	either	either	CC	CC	_	35	cc:preconj	_	_
34	MMTV	mmtv	NN	NN	_	35	compound	_	_
35	LTR	ltr	NN	NN	_	31	nmod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	GRE	gre	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	15	punct	_	_

1	Conversely	conversely	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	c-jun	c-jun	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	jun-B	jun-b	NN	NN	_	3	conj	_	_
6	transfection	transfection	NN	NN	_	7	nsubj	_	_
7	blunted	blunt	VBD	VBD	_	0	root	_	_
8	GR-dependent	gr-dependent	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	HeLa	hela	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-fos	c-fos	NN	NN	_	2	nmod	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	influence	influence	NN	NN	_	5	dobj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	GR	gr	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	correlated	correlate	VBD	VBD	_	5	conj	_	_
14	with	with	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	cell-specific	cell-specific	JJ	JJ	_	20	amod	_	_
17	synergistic	synergistic	JJ	JJ	_	20	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	antagonistic	antagonistic	JJ	JJ	_	17	conj	_	_
20	activity	activity	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Jun	jun	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	respect	respect	NN	NN	_	26	dep	_	_
25	to	to	TO	TO	_	26	case	_	_
26	GR	gr	NN	NN	_	13	nmod	_	_
27	;	;	:	:	_	5	punct	_	_
28	high	high	JJ	JJ	_	30	amod	_	_
29	basal	basal	JJ	JJ	_	30	amod	_	_
30	expression	expression	NN	NN	_	43	nsubjpass	_	_
31	of	of	IN	IN	_	32	case	_	_
32	c-fos	c-fos	NN	NN	_	30	nmod	_	_
33	as	as	RB	RB	_	30	cc	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	as	as	IN	IN	_	33	mwe	_	_
36	AP-1	ap-1	NN	NN	_	38	compound	_	_
37	DNA	dna	NN	NN	_	38	compound	_	_
38	binding	binding	NN	NN	_	30	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	transcriptional	transcriptional	JJ	JJ	_	41	amod	_	_
41	activity	activity	NN	NN	_	38	conj	_	_
42	were	be	VBD	VBD	_	43	auxpass	_	_
43	observed	observe	VBN	VBN	_	5	parataxis	_	_
44	in	in	IN	IN	_	46	case	_	_
45	HeLa	hela	NN	NN	_	46	compound	_	_
46	cells	cell	NNS	NNS	_	43	nmod	_	_
47	,	,	,	,	_	46	punct	_	_
48	but	but	CC	CC	_	46	cc	_	_
49	not	not	RB	RB	_	52	neg	_	_
50	in	in	IN	IN	_	52	case	_	_
51	T	t	NN	NN	_	52	compound	_	_
52	cells	cell	NNS	NNS	_	46	conj	_	_
53	.	.	.	.	_	43	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	overexpression	overexpression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	exogenous	exogenous	JJ	JJ	_	5	amod	_	_
5	c-fos	c-fos	NN	NN	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	GR-dependent	gr-dependent	JJ	JJ	_	12	amod	_	_
12	transcription	transcription	NN	NN	_	6	nmod	_	_
13	from	from	IN	IN	_	14	case	_	_
14	GRE	gre	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	Jun	jun	NN	NN	_	5	nsubj	_	_
5	plays	play	VBZ	VBZ	_	2	ccomp	_	_
6	a	a	DT	DT	_	8	det	_	_
7	bifunctional	bifunctional	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	on	on	IN	IN	_	12	case	_	_
10	GR-dependent	gr-dependent	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GRE	gre	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	selecting	select	VBG	VBG	_	5	advcl	_	_
17	either	either	CC	CC	_	18	cc:preconj	_	_
18	synergistic	synergistic	JJ	JJ	_	21	amod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	antagonistic	antagonistic	JJ	JJ	_	18	conj	_	_
21	activity	activity	NN	NN	_	16	dobj	_	_
22	depending	depend	VBG	VBG	_	26	case	_	_
23	on	on	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cell-specific	cell-specific	JJ	JJ	_	26	amod	_	_
26	microenvironment	microenvironment	NN	NN	_	16	advcl	_	_
27	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	regard	regard	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	c-fos	c-fos	NN	NN	_	6	nmod	_	_
9	appear	appear	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	influential	influential	JJ	JJ	_	9	xcomp	_	_
13	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	concatenated	concatenated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	DNA	dna	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	lymphoblastoid	lymphoblastoid	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	3	nmod	_	_
12	induced	induce	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	transfection	transfection	NN	NN	_	12	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	BZLF1	bzlf1	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	replicative	replicative	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
6	virus	virus	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EBV	ebv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	DNA	dna	NN	NN	_	3	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	studied	study	VBN	VBN	_	0	root	_	_
13	using	use	VBG	VBG	_	12	xcomp	_	_
14	two	two	CD	CD	_	17	nummod	_	_
15	lymphoblastoid	lymphoblastoid	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	X50-7	x50-7	NN	NN	_	17	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	6F11	6f11	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	which	which	WDT	WDT	_	26	nsubjpass	_	_
24	are	be	VBP	VBP	_	26	auxpass	_	_
25	latently	latently	RB	RB	_	26	advmod	_	_
26	infected	infect	VBN	VBN	_	17	acl:relcl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	Epstein-Barr	epstein-barr	JJ	JJ	_	29	amod	_	_
29	virus	virus	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	lytic	lytic	JJ	JJ	_	3	amod	_	_
3	cycle	cycle	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	EBV	ebv	NN	NN	_	6	compound	_	_
6	infection	infection	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	transfection	transfection	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	BRLF1/BZLF1	brlf1/bzlf1	NN	NN	_	18	compound	_	_
17	coding	coding	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	P3HR-1	p3hr-1	NN	NN	_	23	compound	_	_
22	defective	defective	JJ	JJ	_	23	amod	_	_
23	genome	genome	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	combined	combine	VBD	VBD	_	0	root	_	_
3	two	two	CD	CD	_	4	nummod	_	_
4	techniques	technique	NNS	NNS	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	identify	identify	VB	VB	_	2	advcl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	productive	productive	JJ	JJ	_	10	amod	_	_
9	replicative	replicative	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	DNA	dna	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	lytic	lytic	JJ	JJ	_	18	amod	_	_
18	cycle-induced	cycle-induced	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Restriction	restriction	NN	NN	_	3	compound	_	_
2	enzyme	enzyme	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	9	nsubj	_	_
4	followed	follow	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	Southern	southern	NN	NN	_	8	compound	_	_
7	blot	blot	NN	NN	_	8	compound	_	_
8	hybridization	hybridization	NN	NN	_	4	nmod	_	_
9	identified	identify	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	fused	fuse	VBN	VBN	_	16	amod	_	_
16	fragment	fragment	NN	NN	_	12	nmod	_	_
17	encompassing	encompass	VBG	VBG	_	16	acl	_	_
18	both	both	DT	DT	_	19	det	_	_
19	ends	end	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	EBV	ebv	NN	NN	_	22	compound	_	_
22	DNA	dna	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	either	either	CC	CC	_	8	cc:preconj	_	_
7	episomal	episomal	JJ	JJ	_	8	amod	_	_
8	DNA	dna	NN	NN	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	concatameric	concatameric	JJ	JJ	_	12	amod	_	_
11	linear	linear	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	8	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	Southern	southern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	in	in	FW	FW	_	8	amod	_	_
6	situ	situ	FW	FW	_	5	dep	_	_
7	lysing	lyse	VBG	VBG	_	8	amod	_	_
8	gels	gel	NNS	NNS	_	3	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	20	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	content	content	NN	NN	_	20	nsubjpass	_	_
14	of	of	IN	IN	_	17	case	_	_
15	linear	linear	JJ	JJ	_	17	amod	_	_
16	EBV	ebv	NN	NN	_	17	compound	_	_
17	DNA	dna	NN	NN	_	13	nmod	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	increased	increase	VBN	VBN	_	9	ccomp	_	_
21	significantly	significantly	RB	RB	_	20	advmod	_	_
22	after	after	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	initiation	initiation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	viral	viral	JJ	JJ	_	29	amod	_	_
28	lytic	lytic	JJ	JJ	_	29	amod	_	_
29	cycle	cycle	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	20	punct	_	_
31	while	while	IN	IN	_	37	mark	_	_
32	the	the	DT	DT	_	33	det	_	_
33	amount	amount	NN	NN	_	37	nsubj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	circular	circular	JJ	JJ	_	36	amod	_	_
36	DNA	dna	NN	NN	_	33	nmod	_	_
37	remained	remain	VBD	VBD	_	20	advcl	_	_
38	approximately	approximately	RB	RB	_	39	advmod	_	_
39	constant	constant	JJ	JJ	_	37	xcomp	_	_
40	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	25	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	source	source	NN	NN	_	25	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	fused	fuse	VBN	VBN	_	12	amod	_	_
12	fragment	fragment	NN	NN	_	8	nmod	_	_
13	encompassing	encompass	VBG	VBG	_	12	acl	_	_
14	both	both	DT	DT	_	15	det	_	_
15	ends	end	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	EBV	ebv	NN	NN	_	18	compound	_	_
18	DNA	dna	NN	NN	_	15	nmod	_	_
19	is	be	VBZ	VBZ	_	25	cop	_	_
20	a	a	DT	DT	_	25	det	_	_
21	concatenated	concatenate	VBN	VBN	_	25	amod	_	_
22	linear	linear	JJ	JJ	_	25	amod	_	_
23	EBV	ebv	NN	NN	_	25	compound	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	molecule	molecule	NN	NN	_	2	ccomp	_	_
26	,	,	,	,	_	25	punct	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	that	that	IN	IN	_	35	mark	_	_
29	such	such	PDT	PDT	_	32	det:predet	_	_
30	a	a	DT	DT	_	32	det	_	_
31	concatenated	concatenate	VBN	VBN	_	32	amod	_	_
32	molecule	molecule	NN	NN	_	35	nsubj	_	_
33	most	most	RBS	RBS	_	34	advmod	_	_
34	likely	likely	RB	RB	_	35	advmod	_	_
35	represents	represent	VBZ	VBZ	_	25	conj	_	_
36	a	a	DT	DT	_	38	det	_	_
37	replicative	replicative	JJ	JJ	_	38	amod	_	_
38	form	form	NN	NN	_	35	dobj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	EBV	ebv	NN	NN	_	41	compound	_	_
41	DNA	dna	NN	NN	_	38	nmod	_	_
42	in	in	IN	IN	_	45	case	_	_
43	productively	productively	RB	RB	_	44	advmod	_	_
44	infected	infected	JJ	JJ	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	beta-globin	beta-globin	NN	NN	_	5	compound	_	_
5	locus	locus	NN	NN	_	1	nmod	_	_
6	.	.	.	.	_	1	punct	_	_

1	Transcription	transcription	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	beta-globin	beta-globin	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	cluster	cluster	NN	NN	_	1	nmod	_	_
8	depends	depend	VBZ	VBZ	_	0	root	_	_
9	upon	upon	IN	IN	_	12	case	_	_
10	upstream	upstream	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	sequences	sequence	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	17	nsubjpass	_	_
15	are	be	VBP	VBP	_	17	auxpass	_	_
16	collectively	collectively	RB	RB	_	17	advmod	_	_
17	termed	term	VBN	VBN	_	12	acl:relcl	_	_
18	the	the	DT	DT	_	21	det	_	_
19	locus	locus	NN	NN	_	21	compound	_	_
20	control	control	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	17	xcomp	_	_
22	.	.	.	.	_	8	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	provided	provide	VBN	VBN	_	0	root	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	insights	insight	NNS	NNS	_	4	dobj	_	_
7	into	into	IN	IN	_	16	mark	_	_
8	how	how	WRB	WRB	_	16	advmod	_	_
9	the	the	DT	DT	_	11	det	_	_
10	individual	individual	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	16	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cluster	cluster	NN	NN	_	11	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	6	acl	_	_
17	through	through	IN	IN	_	18	case	_	_
18	development	development	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	crux	crux	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	how	how	WRB	WRB	_	12	advmod	_	_
8	the	the	DT	DT	_	11	det	_	_
9	locus	locus	NN	NN	_	11	compound	_	_
10	control	control	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	12	nsubj	_	_
12	communicates	communicate	VBZ	VBZ	_	6	ccomp	_	_
13	with	with	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	gene-proximal	gene-proximal	JJ	JJ	_	17	amod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	elements	element	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Ectopic	ectopic	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	a	a	DT	DT	_	8	det	_	_
5	conditional	conditional	JJ	JJ	_	8	amod	_	_
6	GATA-2/estrogen	gata-2/estrogen	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	chimera	chimera	NN	NN	_	2	nmod	_	_
9	arrests	arrest	VBZ	VBZ	_	0	root	_	_
10	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	hormone-dependent	hormone-dependent	JJ	JJ	_	15	amod	_	_
15	manner	manner	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GATA	gata	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	family	family	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	eukaryotes	eukaryote	NNS	NNS	_	10	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	share	share	VBP	VBP	_	12	acl:relcl	_	_
15	extensive	extensive	JJ	JJ	_	16	amod	_	_
16	homology	homology	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	domains	domain	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	enigmatic	enigmatic	JJ	JJ	_	3	amod	_	_
3	aspect	aspect	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	GATA	gata	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	24	mark	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	GATA	gata	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	24	nsubjpass	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	nsubj	_	_
15	ostensibly	ostensibly	RB	RB	_	16	advmod	_	_
16	share	share	VBP	VBP	_	12	acl:relcl	_	_
17	the	the	DT	DT	_	21	det	_	_
18	same	same	JJ	JJ	_	21	amod	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	21	amod	_	_
20	site	site	NN	NN	_	21	compound	_	_
21	specificity	specificity	NN	NN	_	16	dobj	_	_
22	,	,	,	,	_	12	punct	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	coexpressed	coexpress	VBN	VBN	_	8	ccomp	_	_
25	in	in	IN	IN	_	27	case	_	_
26	erythroid	erythroid	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	22	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	roles	role	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	individual	individual	JJ	JJ	_	8	amod	_	_
7	GATA	gata	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	erythropoiesis	erythropoiesis	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	22	punct	_	_
12	conditional	conditional	JJ	JJ	_	13	amod	_	_
13	alleles	allele	NNS	NNS	_	22	nsubjpass	_	_
14	of	of	IN	IN	_	15	case	_	_
15	GATA-1	gata-1	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	GATA-2	gata-2	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	GATA-3	gata-3	NN	NN	_	15	conj	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	prepared	prepare	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	fusing	fuse	VBG	VBG	_	22	advcl	_	_
25	each	each	DT	DT	_	24	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	to	to	TO	TO	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	hormone-binding	hormone-binding	JJ	JJ	_	32	amod	_	_
32	domain	domain	NN	NN	_	24	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	human	human	JJ	JJ	_	37	amod	_	_
36	estrogen	estrogen	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	ER	er	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	GATA/ER	gata/er	NN	NN	_	4	compound	_	_
3	chimeric	chimeric	JJ	JJ	_	4	amod	_	_
4	factors	factor	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	11	mark	_	_
8	be	be	VB	VB	_	11	cop	_	_
9	hormone-inducible	hormone-inducible	JJ	JJ	_	11	amod	_	_
10	trans-activating	trans-activating	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	6	xcomp	_	_
12	in	in	IN	IN	_	15	case	_	_
13	transient	transient	JJ	JJ	_	15	amod	_	_
14	transfection	transfection	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	When	when	WRB	WRB	_	3	advmod	_	_
2	stably	stably	RB	RB	_	3	advmod	_	_
3	introduced	introduce	VBN	VBN	_	16	advcl	_	_
4	into	into	IN	IN	_	6	case	_	_
5	primary	primary	JJ	JJ	_	6	amod	_	_
6	erythroblasts	erythroblast	NNS	NNS	_	3	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	conditionally	conditionally	RB	RB	_	9	advmod	_	_
9	transformed	transform	VBN	VBN	_	12	amod	_	_
10	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
11	progenitors	progenitor	NNS	NNS	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	conj	_	_
13	,	,	,	,	_	16	punct	_	_
14	exogenous	exogenous	JJ	JJ	_	15	amod	_	_
15	GATA-2/ER	gata-2/er	NN	NN	_	16	nsubj	_	_
16	promoted	promote	VBD	VBD	_	0	root	_	_
17	proliferation	proliferation	NN	NN	_	16	dobj	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	inhibited	inhibit	VBD	VBD	_	16	conj	_	_
20	terminal	terminal	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	an	a	DT	DT	_	25	det	_	_
24	estrogen-dependent	estrogen-dependent	JJ	JJ	_	25	amod	_	_
25	manner	manner	NN	NN	_	16	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	phenotypic	phenotypic	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	specifically	specifically	RB	RB	_	6	advmod	_	_
6	attributable	attributable	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	action	action	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	ectopically	ectopically	RB	RB	_	12	advmod	_	_
12	expressed	express	VBN	VBN	_	13	amod	_	_
13	GATA-2/ER	gata-2/er	NN	NN	_	9	nmod	_	_
14	because	because	IN	IN	_	21	mark	_	_
15	erythroblasts	erythroblast	NNS	NNS	_	21	nsubjpass	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	exogenous	exogenous	JJ	JJ	_	18	amod	_	_
18	GATA-2	gata-2	NN	NN	_	16	dobj	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	constitutively	constitutively	RB	RB	_	21	advmod	_	_
21	arrested	arrest	VBN	VBN	_	6	advcl	_	_
22	in	in	IN	IN	_	23	case	_	_
23	differentiation	differentiation	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	because	because	IN	IN	_	35	mark	_	_
26	erythroid	erythroid	JJ	JJ	_	27	amod	_	_
27	progenitors	progenitor	NNS	NNS	_	35	nsubj	_	_
28	expressing	express	VBG	VBG	_	27	acl	_	_
29	either	either	CC	CC	_	30	cc:preconj	_	_
30	Gal/ER	gal/er	NN	NN	_	28	dobj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	GATA-3/ER	gata-3/er	NN	NN	_	30	conj	_	_
33	do	do	VBP	VBP	_	35	aux	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	display	display	VB	VB	_	21	conj	_	_
36	a	a	DT	DT	_	38	det	_	_
37	hormone-responsive	hormone-responsive	JJ	JJ	_	38	amod	_	_
38	block	block	NN	NN	_	35	dobj	_	_
39	in	in	IN	IN	_	40	case	_	_
40	differentiation	differentiation	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	GATA-2	gata-2	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	7	nsubj	_	_
7	appears	appear	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	play	play	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	regulating	regulate	VBG	VBG	_	9	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	self-renewal	self-renewal	JJ	JJ	_	16	amod	_	_
16	capacity	capacity	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	early	early	JJ	JJ	_	21	amod	_	_
19	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
20	progenitor	progenitor	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	MAD3	mad3	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	activation	activation	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	c-Rel	c-rel	NN	NN	_	14	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	related	related	JJ	JJ	_	13	amod	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	9	conj	_	_
14	proteins	protein	NNS	NNS	_	7	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
18	THP-1	thp-1	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	3	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Many	many	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	26	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LPS	lps	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	on	on	IN	IN	_	10	case	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	2	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	that	that	DT	DT	_	2	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
17	virus	virus	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HIV	hiv	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	2	punct	_	_
22	in	in	IN	IN	_	24	case	_	_
23	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	2	nmod	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	mediated	mediate	VBN	VBN	_	0	root	_	_
27	by	by	IN	IN	_	28	case	_	_
28	activation	activation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	kappa	kappa	NN	NN	_	33	compound	_	_
31	B	b	NN	NN	_	33	compound	_	_
32	DNA-binding	dna-binding	JJ	JJ	_	33	amod	_	_
33	proteins	protein	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	26	punct	_	_

1	However	however	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	members	member	NNS	NNS	_	28	nsubj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
9	B/Rel	b/rel	NN	NN	_	12	compound	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	5	nmod	_	_
13	involved	involve	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	LPS	lps	NN	NN	_	17	compound	_	_
17	response	response	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	mechanisms	mechanism	NNS	NNS	_	5	conj	_	_
22	through	through	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	27	nmod	_	_
24	LPS-generated	lps-generated	JJ	JJ	_	25	amod	_	_
25	signals	signal	NNS	NNS	_	27	nsubjpass	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	transduced	transduce	VBN	VBN	_	21	acl:relcl	_	_
28	remain	remain	VBP	VBP	_	0	root	_	_
29	unclear	unclear	JJ	JJ	_	28	xcomp	_	_
30	.	.	.	.	_	28	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	LPS	lps	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	c-Rel/p50	c-rel/p50	NN	NN	_	11	compound	_	_
11	heterodimers	heterodimer	NNS	NNS	_	8	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	p50/p65	p50/p65	NN	NN	_	23	compound	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	kappa	kappa	NN	NN	_	23	compound	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	complexes	complex	NNS	NNS	_	11	conj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	monocytic	monocytic	JJ	JJ	_	28	amod	_	_
27	THP-1	thp-1	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	6	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	localization	localization	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	occurred	occur	VBD	VBD	_	0	root	_	_
7	concomitantly	concomitantly	RB	RB	_	11	advmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	rapid	rapid	JJ	JJ	_	11	amod	_	_
11	decrease	decrease	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	cytosolic	cytosolic	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	independent	independent	JJ	JJ	_	6	conj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	phorbol	phorbol	NN	NN	_	21	nmod:npmod	_	_
21	ester-sensitive	ester-sensitive	JJ	JJ	_	24	amod	_	_
22	protein	protein	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	C	c	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	24	24	CD	CD	_	3	nummod	_	_
3	h	h	NN	NN	_	8	nmod	_	_
4	following	follow	VBG	VBG	_	6	case	_	_
5	LPS	lps	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	3	nmod	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	was	be	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	striking	striking	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	8	nsubj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	levels	level	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	c-Rel	c-rel	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	p105	p105	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	p50	p50	NN	NN	_	16	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cytosol	cytosol	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	levels	level	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	proteins	protein	NNS	NNS	_	3	nmod	_	_
7	correlated	correlate	VBD	VBD	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	increases	increase	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	amounts	amount	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	mRNAs	mrna	NNS	NNS	_	12	nmod	_	_
16	during	during	IN	IN	_	18	case	_	_
17	LPS	lps	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	9	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	THP-1	thp-1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	THP-1	thp-1	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	MAD3	mad3	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	an	a	DT	DT	_	16	det	_	_
13	I	i	NN	NN	_	15	nmod:npmod	_	_
14	kappa	kappa	NN	NN	_	15	nmod:npmod	_	_
15	B-like	b-like	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	10	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	8	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	rapid	rapid	JJ	JJ	_	21	amod	_	_
21	increase	increase	NN	NN	_	8	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	MAD3	mad3	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	8	punct	_	_
26	and	and	CC	CC	_	8	cc	_	_
27	an	a	DT	DT	_	28	det	_	_
28	increase	increase	NN	NN	_	8	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	MAD3	mad3	NN	NN	_	31	compound	_	_
31	protein	protein	NN	NN	_	28	nmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	2	2	CD	CD	_	34	nummod	_	_
34	h	h	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	LPS	lps	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	c-Rel/p50	c-rel/p50	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	p50/p65	p50/p65	NN	NN	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	induces	induce	VBZ	VBZ	_	9	conj	_	_
23	phosphorylation	phosphorylation	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	MAD3	mad3	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	CD8	cd8	NN	NN	_	7	compound	_	_
4	antigen	antigen	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	suppressor	suppressor	NN	NN	_	4	conj	_	_
7	activity	activity	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
10	in	in	IN	IN	_	16	case	_	_
11	a	a	DT	DT	_	16	det	_	_
12	CEM	cem	NN	NN	_	16	compound	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	clone	clone	NN	NN	_	1	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	relationship	relationship	NN	NN	_	13	nsubjpass	_	_
3	between	between	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	effect	effect	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	regulation	regulation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	surface	surface	NN	NN	_	11	compound	_	_
11	antigens	antigen	NNS	NNS	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	investigated	investigate	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	two	two	CD	CD	_	16	nummod	_	_
16	models	model	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	leukemic	leukemic	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	CEM	cem	NN	NN	_	23	compound	_	_
23	C7	c7	NN	NN	_	16	appos	_	_
24	denoted	denote	VBN	VBN	_	23	acl	_	_
25	(	(	-LRB-	-LRB-	_	23	punct	_	_
26	r+	r+	JJ	JJ	_	23	amod	_	_
27	,	,	,	,	_	26	punct	_	_
28	ly+	ly+	JJ	JJ	_	26	dep	_	_
29	)	)	-RRB-	-RRB-	_	23	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	CEM	cem	NN	NN	_	32	compound	_	_
32	C1	c1	NN	NN	_	23	conj	_	_
33	(	(	-LRB-	-LRB-	_	32	punct	_	_
34	r+	r+	JJ	JJ	_	32	amod	_	_
35	,	,	,	,	_	34	punct	_	_
36	ly-	ly-	JJ	JJ	_	34	dep	_	_
37	)	)	-RRB-	-RRB-	_	32	punct	_	_
38	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reactivity	reactivity	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	murine	murine	JJ	JJ	_	6	amod	_	_
5	monoclonal	monoclonal	JJ	JJ	_	6	amod	_	_
6	antibodies	antibody	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	anti-CD4-FITC	anti-cd4-fitc	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	anti-CD8-FITC	anti-cd8-fitc	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	anti-CD2-FITC	anti-cd2-fitc	NN	NN	_	8	conj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	anti-calla-FITC	anti-calla-fitc	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	6	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	analyzed	analyze	VBN	VBN	_	0	root	_	_
18	using	use	VBG	VBG	_	17	xcomp	_	_
19	flow	flow	NN	NN	_	20	compound	_	_
20	cytometry	cytometry	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	suppressor	suppressor	NN	NN	_	3	compound	_	_
3	function	function	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	determined	determine	VBN	VBN	_	0	root	_	_
6	using	use	VBG	VBG	_	5	xcomp	_	_
7	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	8	compound	_	_
8	incorporation	incorporation	NN	NN	_	6	dobj	_	_
9	into	into	IN	IN	_	13	case	_	_
10	phytohemagglutinin-activated	phytohemagglutinin-activated	JJ	JJ	_	13	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	10	case	_	_
4	a	a	DT	DT	_	10	det	_	_
5	human	human	JJ	JJ	_	10	amod	_	_
6	leukemic	leukemic	JJ	JJ	_	10	amod	_	_
7	cell	cell	NN	NN	_	10	compound	_	_
8	clone	clone	NN	NN	_	10	compound	_	_
9	CEM	cem	NN	NN	_	10	compound	_	_
10	C7	c7	NN	NN	_	2	nmod	_	_
11	caused	cause	VBD	VBD	_	0	root	_	_
12	an	a	DT	DT	_	13	det	_	_
13	increase	increase	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	subset	subset	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	expressing	express	VBG	VBG	_	18	acl	_	_
20	the	the	DT	DT	_	23	det	_	_
21	surface	surface	NN	NN	_	23	compound	_	_
22	antigen	antigen	NN	NN	_	23	compound	_	_
23	CD8	cd8	NN	NN	_	19	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	present	present	JJ	JJ	_	23	acl:relcl	_	_
28	on	on	IN	IN	_	32	case	_	_
29	suppressor	suppressor	NN	NN	_	32	compound	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	cytotoxic	cytotoxic	JJ	JJ	_	29	conj	_	_
32	T-lymphocytes	t-lymphocyte	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	modification	modification	NN	NN	_	5	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD4	cd4	NN	NN	_	13	compound	_	_
13	antigen	antigen	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	13	acl:relcl	_	_
18	at	at	IN	IN	_	20	case	_	_
19	high	high	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	days	day	NNS	NNS	_	16	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	treatment	treatment	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	11	case	_	_
7	5	5	CD	CD	_	8	compound	_	_
8	x	x	NN	NN	_	10	dep	_	_
9	10(-8)	10(-8)	CD	CD	_	8	compound	_	_
10	M	m	NN	NN	_	11	dep	_	_
11	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	CEM	cem	NN	NN	_	15	compound	_	_
14	C7	c7	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	16	nsubj	_	_
16	showed	show	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	two-fold	two-fold	JJ	JJ	_	19	amod	_	_
19	increase	increase	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	suppressor	suppressor	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	compared	compare	VBN	VBN	_	26	case	_	_
24	to	to	TO	TO	_	26	case	_	_
25	untreated	untreated	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	19	acl	_	_
27	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	regulation	regulation	NN	NN	_	5	nsubj	_	_
8	by	by	IN	IN	_	9	case	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	16	case	_	_
11	either	either	CC	CC	_	16	cc:preconj	_	_
12	the	the	DT	DT	_	16	det	_	_
13	CD8	cd8	NN	NN	_	16	compound	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	CD4	cd4	NN	NN	_	13	conj	_	_
16	antigens	antigen	NNS	NNS	_	9	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	leukemic	leukemic	JJ	JJ	_	22	amod	_	_
20	clone	clone	NN	NN	_	22	compound	_	_
21	CEM	cem	NN	NN	_	22	compound	_	_
22	C1	c1	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	modification	modification	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	suppressor	suppressor	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	CEM	cem	NN	NN	_	12	compound	_	_
11	C1	c1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	4	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	leukemic	leukemic	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	20	nmod	_	_
6	studied	study	VBN	VBN	_	5	acl	_	_
7	here	here	RB	RB	_	6	advmod	_	_
8	,	,	,	,	_	20	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	ability	ability	NN	NN	_	20	nsubj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	induce	induce	VB	VB	_	10	acl	_	_
13	CD8	cd8	NN	NN	_	15	compound	_	_
14	antigen	antigen	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	CD4+	cd4+	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	correlates	correlate	VBZ	VBZ	_	0	root	_	_
21	with	with	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	ability	ability	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	induce	induce	VB	VB	_	23	acl	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lysis	lysis	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	34	case	_	_
29	a	a	DT	DT	_	34	det	_	_
30	glucocorticoid	glucocorticoid	NN	NN	_	34	compound	_	_
31	receptor	receptor	NN	NN	_	34	compound	_	_
32	positive	positive	JJ	JJ	_	34	amod	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	population	population	NN	NN	_	25	nmod	_	_
35	.	.	.	.	_	20	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	basis	basis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	multiple	multiple	JJ	JJ	_	7	amod	_	_
6	lymphokine	lymphokine	NN	NN	_	7	compound	_	_
7	deficiency	deficiency	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	patient	patient	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	severe	severe	JJ	JJ	_	14	amod	_	_
13	combined	combined	JJ	JJ	_	14	amod	_	_
14	immunodeficiency	immunodeficiency	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	17	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	child	child	NN	NN	_	8	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	severe	severe	JJ	JJ	_	15	amod	_	_
14	combined	combined	JJ	JJ	_	15	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	11	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	defective	defective	JJ	JJ	_	4	ccomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	transcription	transcription	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	several	several	JJ	JJ	_	24	amod	_	_
23	lymphokine	lymphokine	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	include	include	VBP	VBP	_	24	acl:relcl	_	_
27	IL2	il2	NN	NN	_	26	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	IL3	il3	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	IL4	il4	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	IL5	il5	NN	NN	_	27	conj	_	_
35	,	,	,	,	_	27	punct	_	_
36	which	which	WDT	WDT	_	37	nsubj	_	_
37	encode	encode	VBP	VBP	_	27	acl:relcl	_	_
38	interleukins	interleukin	NNS	NNS	_	37	dobj	_	_
39	2	2	CD	CD	_	38	dep	_	_
40	,	,	,	,	_	39	punct	_	_
41	3	3	CD	CD	_	39	conj	_	_
42	,	,	,	,	_	39	punct	_	_
43	4	4	CD	CD	_	39	conj	_	_
44	,	,	,	,	_	39	punct	_	_
45	and	and	CC	CC	_	39	cc	_	_
46	5	5	CD	CD	_	39	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	IL-2	il-2	NN	NN	_	38	dep	_	_
49	,	,	,	,	_	48	punct	_	_
50	-3	-3	CD	CD	_	48	conj	_	_
51	,	,	,	,	_	48	punct	_	_
52	-4	-4	CD	CD	_	48	conj	_	_
53	,	,	,	,	_	48	punct	_	_
54	and	and	CC	CC	_	48	cc	_	_
55	-5	-5	CD	CD	_	48	conj	_	_
56	)	)	-RRB-	-RRB-	_	48	punct	_	_
57	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	24	advcl	_	_
3	whether	whether	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	defect	defect	NN	NN	_	12	nsubj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	patient	patient	NN	NN	_	11	nmod:poss	_	_
9	's	's	POS	POS	_	8	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	involved	involve	VBD	VBD	_	2	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	trans-acting	trans-acting	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	12	dobj	_	_
16	common	common	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	affected	affect	VBN	VBN	_	21	amod	_	_
20	lymphokine	lymphokine	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	examined	examine	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	ability	ability	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	factors	factor	NNS	NNS	_	26	nmod	_	_
30	from	from	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	patient	patient	NN	NN	_	35	nmod:poss	_	_
33	's	's	POS	POS	_	32	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	lymphocytes	lymphocyte	NNS	NNS	_	29	nmod	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	bind	bind	VB	VB	_	26	acl	_	_
38	response	response	NN	NN	_	39	compound	_	_
39	elements	element	NNS	NNS	_	37	dobj	_	_
40	present	present	JJ	JJ	_	39	amod	_	_
41	in	in	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	regulatory	regulatory	JJ	JJ	_	44	amod	_	_
44	region	region	NN	NN	_	40	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	IL2	il2	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	24	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	NF-kB	nf-kb	NN	NN	_	19	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	3	conj	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	AP-1	ap-1	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	3	punct	_	_
12	OCT-1	oct-1	NN	NN	_	3	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	NF-IL-2B	nf-il-2b	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	3	conj	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	normal	normal	JJ	JJ	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	37	nmod	_	_
3	,	,	,	,	_	37	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	37	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NF-AT	nf-at	NN	NN	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	to	to	TO	TO	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	5	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IL2	il2	NN	NN	_	24	compound	_	_
24	enhancer	enhancer	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	to	to	TO	TO	_	30	case	_	_
27	an	a	DT	DT	_	30	det	_	_
28	NF-AT-like	nf-at-like	JJ	JJ	_	30	amod	_	_
29	response	response	NN	NN	_	30	compound	_	_
30	element	element	NN	NN	_	20	conj	_	_
31	present	present	JJ	JJ	_	30	amod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	IL4	il4	NN	NN	_	35	compound	_	_
35	enhancer	enhancer	NN	NN	_	31	nmod	_	_
36	was	be	VBD	VBD	_	37	cop	_	_
37	abnormal	abnormal	JJ	JJ	_	0	root	_	_
38	.	.	.	.	_	37	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	ascertain	ascertain	VB	VB	_	17	advcl	_	_
3	whether	whether	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	abnormal	abnormal	JJ	JJ	_	8	amod	_	_
6	NF-AT	nf-at	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	10	nsubj	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	related	related	JJ	JJ	_	2	ccomp	_	_
11	to	to	TO	TO	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	impaired	impaired	JJ	JJ	_	14	amod	_	_
14	function	function	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	transfected	transfect	VBD	VBD	_	0	root	_	_
18	patient	patient	NN	NN	_	22	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	control	control	NN	NN	_	18	conj	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	dobj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	constructs	construct	NNS	NNS	_	17	nmod	_	_
25	containing	contain	VBG	VBG	_	24	acl	_	_
26	the	the	DT	DT	_	28	det	_	_
27	reporter	reporter	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	25	dobj	_	_
29	encoding	encoding	JJ	JJ	_	28	dep	_	_
30	chloramphenicol	chloramphenicol	NN	NN	_	32	compound	_	_
31	acetyl	acetyl	NN	NN	_	32	compound	_	_
32	transferase	transferase	NN	NN	_	29	dobj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	CAT	cat	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	under	under	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	control	control	NN	NN	_	32	nmod	_	_
39	of	of	IN	IN	_	44	case	_	_
40	the	the	DT	DT	_	44	det	_	_
41	entire	entire	JJ	JJ	_	44	amod	_	_
42	IL2	il2	NN	NN	_	44	compound	_	_
43	regulatory	regulatory	JJ	JJ	_	44	amod	_	_
44	region	region	NN	NN	_	38	nmod	_	_
45	or	or	CC	CC	_	44	cc	_	_
46	of	of	IN	IN	_	47	case	_	_
47	multimers	multimer	NNS	NNS	_	44	conj	_	_
48	of	of	IN	IN	_	51	case	_	_
49	individual	individual	JJ	JJ	_	51	amod	_	_
50	enhancer	enhancer	NN	NN	_	51	compound	_	_
51	sequences	sequence	NNS	NNS	_	47	nmod	_	_
52	.	.	.	.	_	17	punct	_	_

1	CAT	cat	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	19	nsubj	_	_
3	directed	direct	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	IL2	il2	NN	NN	_	8	compound	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	3	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	by	by	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	multimer	multimer	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	NF-AT-binding	nf-at-binding	JJ	JJ	_	16	amod	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	was	be	VBD	VBD	_	19	cop	_	_
18	markedly	markedly	RB	RB	_	19	advmod	_	_
19	lower	lower	JJR	JJR	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	patient	patient	NN	NN	_	19	nmod	_	_
23	relative	relative	JJ	JJ	_	25	case	_	_
24	to	to	TO	TO	_	25	case	_	_
25	controls	control	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	CAT	cat	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	21	nsubj	_	_
7	directed	direct	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	multimer	multimer	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	19	case	_	_
12	the	the	DT	DT	_	19	det	_	_
13	OCT-1	oct-1	NN	NN	_	18	nmod:npmod	_	_
14	proximal	proximal	NN	NN	_	18	nmod:npmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	OCT-1p	oct-1p	NN	NN	_	18	nmod:npmod	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	-binding	-binding	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	10	nmod	_	_
20	was	be	VBD	VBD	_	21	cop	_	_
21	equivalent	equivalent	JJ	JJ	_	0	root	_	_
22	in	in	IN	IN	_	23	case	_	_
23	patient	patient	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	controls	control	NNS	NNS	_	23	conj	_	_
26	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	an	a	DT	DT	_	6	det	_	_
6	abnormality	abnormality	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	6	dep	_	_
8	/or	/or	CC	CC	_	7	cc	_	_
9	influencing	influencing	JJ	JJ	_	7	conj	_	_
10	NF-AT	nf-at	NN	NN	_	7	dep	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	underlie	underlie	VB	VB	_	3	ccomp	_	_
13	the	the	DT	DT	_	16	det	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	lymphokine	lymphokine	NN	NN	_	16	compound	_	_
16	deficiency	deficiency	NN	NN	_	12	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	patient	patient	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	mRNA	mrna	NN	NN	_	1	nmod	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	GATA-binding	gata-binding	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	eosinophils	eosinophil	NNS	NNS	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	basophils	basophil	NNS	NNS	_	10	conj	_	_
13	:	:	:	:	_	1	punct	_	_
14	potential	potential	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	1	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	GATA-1	gata-1	NN	NN	_	7	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	GATA-2	gata-2	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	GATA-3	gata-3	NN	NN	_	8	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	studied	study	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	eosinophils	eosinophil	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	basophils	basophil	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	15	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	2	nsubj	_	_
2	express	express	VBP	VBP	_	0	root	_	_
3	mRNA	mrna	NN	NN	_	2	dobj	_	_
4	for	for	IN	IN	_	5	case	_	_
5	GATA-1	gata-1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	GATA-2	gata-2	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	GATA-3	gata-3	NN	NN	_	5	conj	_	_
11	.	.	.	.	_	2	punct	_	_

1	Basophils	basophil	NNS	NNS	_	2	nsubj	_	_
2	express	express	VBP	VBP	_	0	root	_	_
3	GATA-2	gata-2	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	GATA-3	gata-3	NN	NN	_	3	conj	_	_
6	.	.	.	.	_	2	punct	_	_

1	Treatment	treatment	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HL-60	hl-60	NN	NN	_	5	compound	_	_
4	eosinophilic	eosinophilic	JJ	JJ	_	5	amod	_	_
5	sublines	subline	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	either	either	CC	CC	_	8	cc:preconj	_	_
8	interleukin-5	interleukin-5	NN	NN	_	1	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	butyric	butyric	JJ	JJ	_	11	amod	_	_
11	acid	acid	NN	NN	_	8	conj	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	GATA-1	gata-1	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	14	nmod	_	_
18	concomitant	concomitant	JJ	JJ	_	12	xcomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	eosinophil-specific	eosinophil-specific	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	whereas	whereas	IN	IN	_	12	dep	_	_
27	levels	level	NNS	NNS	_	31	nsubj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	GATA-2	gata-2	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	27	nmod	_	_
31	remained	remain	VBD	VBD	_	12	parataxis	_	_
32	relatively	relatively	RB	RB	_	33	advmod	_	_
33	constant	constant	JJ	JJ	_	31	xcomp	_	_
34	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	mRNA	mrna	NN	NN	_	2	nmod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	proteins	protein	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	eosinophils	eosinophil	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	basophils	basophil	NNS	NNS	_	9	conj	_	_
12	suggests	suggest	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	21	mark	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	21	nsubjpass	_	_
16	in	in	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	lineages	lineage	NNS	NNS	_	15	nmod	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	regulated	regulate	VBN	VBN	_	12	ccomp	_	_
22	by	by	IN	IN	_	24	case	_	_
23	GATA-binding	gata-binding	JJ	JJ	_	24	amod	_	_
24	proteins	protein	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Proliferation	proliferation	NN	NN	_	2	compound	_	_
2	index	index	NN	NN	_	0	root	_	_
3	as	as	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	prognostic	prognostic	JJ	JJ	_	6	amod	_	_
6	marker	marker	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	breast	breast	NN	NN	_	9	compound	_	_
9	cancer	cancer	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proliferative	proliferative	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	tumors	tumor	NNS	NNS	_	3	nmod	_	_
6	has	have	VBZ	VBZ	_	9	aux	_	_
7	been	be	VBN	VBN	_	9	auxpass	_	_
8	extensively	extensively	RB	RB	_	9	advmod	_	_
9	investigated	investigate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	approaches	approach	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	among	among	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	23	nmod	_	_
16	the	the	DT	DT	_	17	det	_	_
17	use	use	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	monoclonal	monoclonal	JJ	JJ	_	22	amod	_	_
21	antibody	antibody	NN	NN	_	22	compound	_	_
22	Ki-67	ki-67	NN	NN	_	17	nmod	_	_
23	represents	represent	VBZ	VBZ	_	12	acl:relcl	_	_
24	an	a	DT	DT	_	28	det	_	_
25	easy	easy	JJ	JJ	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	reliable	reliable	JJ	JJ	_	25	conj	_	_
28	means	means	NN	NN	_	23	dobj	_	_
29	of	of	IN	IN	_	30	mark	_	_
30	assessing	assess	VBG	VBG	_	28	acl	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	proliferation	proliferation	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	proliferative	proliferative	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	12	case	_	_
9	129	129	CD	CD	_	12	nummod	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	breast	breast	NN	NN	_	12	compound	_	_
12	cancers	cancer	NNS	NNS	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	investigated	investigate	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	results	result	NNS	NNS	_	20	nsubj	_	_
19	were	be	VBD	VBD	_	20	aux	_	_
20	related	related	JJ	JJ	_	14	conj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	prognosis	prognosis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Tumor	tumor	NN	NN	_	2	compound	_	_
2	samples	sample	NNS	NNS	_	19	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	obtained	obtain	VBN	VBN	_	2	acl	_	_
5	from	from	IN	IN	_	7	case	_	_
6	129	129	CD	CD	_	7	nummod	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	who	who	WP	WP	_	9	nsubj	_	_
9	underwent	undergo	VBD	VBD	_	7	acl:relcl	_	_
10	surgery	surgery	NN	NN	_	9	dobj	_	_
11	between	between	IN	IN	_	12	case	_	_
12	January	January	NNP	NNP	_	9	nmod	_	_
13	1987	1987	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	December	December	NNP	NNP	_	12	conj	_	_
16	1988	1988	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	2	punct	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	processed	process	VBN	VBN	_	0	root	_	_
20	for	for	IN	IN	_	21	case	_	_
21	staining	stain	VBG	VBG	_	19	nmod	_	_
22	by	by	IN	IN	_	25	case	_	_
23	an	a	DT	DT	_	25	det	_	_
24	immunohistochemical	immunohistochemical	JJ	JJ	_	25	amod	_	_
25	procedure	procedure	NN	NN	_	19	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	avidin-biotin	avidin-biotin	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	median	median	JJ	JJ	_	3	amod	_	_
3	time	time	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	observation	observation	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	42	42	CD	CD	_	8	nummod	_	_
8	months	month	NNS	NNS	_	0	root	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	range	range	NN	NN	_	13	dep	_	_
11	,	,	,	,	_	13	punct	_	_
12	31-55	31-55	CD	CD	_	13	nummod	_	_
13	months	month	NNS	NNS	_	8	parataxis	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	8	punct	_	_

1	Life-table	life-table	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	Mantel-Cox	mantel-cox	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	assess	assess	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	probability	probability	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	disease-free	disease-free	JJ	JJ	_	14	amod	_	_
14	survival	survival	NN	NN	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	DFS	dfs	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	overall	overall	JJ	JJ	_	20	amod	_	_
20	survival	survival	NN	NN	_	14	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	OS	os	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	7	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Tumors	tumor	NNS	NNS	_	13	nsubjpass	_	_
2	with	with	IN	IN	_	6	case	_	_
3	high	high	JJ	JJ	_	6	amod	_	_
4	Ki-67	ki-67	NN	NN	_	6	compound	_	_
5	proliferation	proliferation	NN	NN	_	6	compound	_	_
6	indices	index	NNS	NNS	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	&gt;	&gt;	JJR	JJR	_	9	advmod	_	_
9	20	20	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	6	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	higher	higher	JJR	JJR	_	18	amod	_	_
17	4-year	4-year	JJ	JJ	_	18	amod	_	_
18	probability	probability	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	relapse	relapse	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	disease	disease	NN	NN	_	20	nmod	_	_
23	(	(	-LRB-	-LRB-	_	31	punct	_	_
24	55.3	55.3	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	31	dep	_	_
26	versus	versus	CC	CC	_	25	cc	_	_
27	79.1	79.1	CD	CD	_	28	nummod	_	_
28	%	%	NN	NN	_	25	conj	_	_
29	;	;	:	:	_	31	punct	_	_
30	P	p	NN	NN	_	31	nsubj	_	_
31	=	=	JJ	JJ	_	20	dep	_	_
32	0.003	0.003	CD	CD	_	31	dobj	_	_
33	)	)	-RRB-	-RRB-	_	31	punct	_	_
34	and	and	CC	CC	_	20	cc	_	_
35	death	death	NN	NN	_	20	conj	_	_
36	(	(	-LRB-	-LRB-	_	44	punct	_	_
37	71	71	CD	CD	_	38	nummod	_	_
38	%	%	NN	NN	_	44	dep	_	_
39	versus	versus	CC	CC	_	38	cc	_	_
40	95.6	95.6	CD	CD	_	41	nummod	_	_
41	%	%	NN	NN	_	38	conj	_	_
42	;	;	:	:	_	44	punct	_	_
43	P	p	NN	NN	_	44	nsubj	_	_
44	=	=	JJ	JJ	_	35	dep	_	_
45	0.00005	0.00005	CD	CD	_	44	dobj	_	_
46	)	)	-RRB-	-RRB-	_	44	punct	_	_
47	when	when	WRB	WRB	_	48	advmod	_	_
48	compared	compare	VBN	VBN	_	13	advcl	_	_
49	with	with	IN	IN	_	50	case	_	_
50	tumors	tumor	NNS	NNS	_	48	nmod	_	_
51	with	with	IN	IN	_	54	case	_	_
52	low	low	JJ	JJ	_	54	amod	_	_
53	Ki-67	ki-67	NN	NN	_	54	compound	_	_
54	values	value	NNS	NNS	_	50	nmod	_	_
55	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	this	this	DT	DT	_	6	det	_	_
5	proliferative	proliferative	JJ	JJ	_	6	amod	_	_
6	parameter	parameter	NN	NN	_	7	nsubj	_	_
7	maintained	maintain	VBD	VBD	_	0	root	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	prognostic	prognostic	JJ	JJ	_	10	amod	_	_
10	significance	significance	NN	NN	_	7	dobj	_	_
11	when	when	WRB	WRB	_	15	advmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	patients	patient	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	stratified	stratify	VBN	VBN	_	7	advcl	_	_
16	according	accord	VBG	VBG	_	20	case	_	_
17	to	to	TO	TO	_	16	mwe	_	_
18	lymph	lymph	NN	NN	_	20	compound	_	_
19	node	node	NN	NN	_	20	compound	_	_
20	involvement	involvement	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	menopausal	menopausal	JJ	JJ	_	23	amod	_	_
23	status	status	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
27	estrogen	estrogen	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	content	content	NN	NN	_	20	conj	_	_
30	.	.	.	.	_	7	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	proliferative	proliferative	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	11	nsubj	_	_
4	as	as	IN	IN	_	5	mark	_	_
5	evaluated	evaluate	VBN	VBN	_	3	dep	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	monoclonal	monoclonal	JJ	JJ	_	10	amod	_	_
9	antibody	antibody	NN	NN	_	10	compound	_	_
10	Ki-67	ki-67	NN	NN	_	5	nmod	_	_
11	seems	seem	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	16	mark	_	_
13	be	be	VB	VB	_	16	cop	_	_
14	an	a	DT	DT	_	16	det	_	_
15	effective	effective	JJ	JJ	_	16	amod	_	_
16	indicator	indicator	NN	NN	_	11	xcomp	_	_
17	of	of	IN	IN	_	18	case	_	_
18	prognosis	prognosis	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	breast	breast	NN	NN	_	21	compound	_	_
21	cancer	cancer	NN	NN	_	18	nmod	_	_
22	for	for	IN	IN	_	23	case	_	_
23	DFS	dfs	NN	NN	_	16	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	OS	os	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	11	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	reactivity	reactivity	NN	NN	_	0	root	_	_
4	to	to	TO	TO	_	9	case	_	_
5	Sjogren	sjogren	NN	NN	_	8	nmod:npmod	_	_
6	's	's	POS	POS	_	8	dep	_	_
7	syndrome	syndrome	NN	NN	_	8	nmod:npmod	_	_
8	related	related	JJ	JJ	_	9	amod	_	_
9	antigen	antigen	NN	NN	_	3	nmod	_	_
10	La	la	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SSB	ssb	NN	NN	_	9	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	.	.	.	.	_	3	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Many	many	JJ	JJ	_	2	amod	_	_
2	patients	patient	NNS	NNS	_	11	nsubj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	primary	primary	JJ	JJ	_	7	amod	_	_
5	Sjogren	sjogren	NN	NN	_	7	nmod:poss	_	_
6	's	's	POS	POS	_	7	case	_	_
7	syndrome	syndrome	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	SS	ss	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	make	make	VBP	VBP	_	0	root	_	_
12	high	high	JJ	JJ	_	13	amod	_	_
13	titer	titer	NN	NN	_	11	dobj	_	_
14	IgG	igg	NN	NN	_	15	compound	_	_
15	autoantibodies	autoantibody	NNS	NNS	_	13	dep	_	_
16	to	to	TO	TO	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	La	la	NN	NN	_	20	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	SSB	ssb	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	antigen	antigen	NN	NN	_	13	nmod	_	_
23	,	,	,	,	_	11	punct	_	_
24	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
25	antigen	antigen	NN	NN	_	30	compound	_	_
26	specific	specific	JJ	JJ	_	30	amod	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	cell-B	cell-b	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	interactions	interaction	NNS	NNS	_	24	dobj	_	_
31	.	.	.	.	_	11	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	responses	response	NNS	NNS	_	14	nsubjpass	_	_
4	to	to	TO	TO	_	7	case	_	_
5	some	some	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	antigens	antigen	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	particularly	particularly	RB	RB	_	10	advmod	_	_
10	U1RNP	u1rnp	NN	NN	_	7	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	systemic	systemic	JJ	JJ	_	20	amod	_	_
19	lupus	lupus	NN	NN	_	20	compound	_	_
20	erythematosus	erythematosus	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	SLE	sle	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	in	in	IN	IN	_	27	case	_	_
26	healthy	healthy	JJ	JJ	_	27	amod	_	_
27	subjects	subject	NNS	NNS	_	16	conj	_	_
28	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	reactivity	reactivity	NN	NN	_	2	dobj	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	autoantigen	autoantigen	NN	NN	_	9	compound	_	_
9	SSB	ssb	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	5	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	SS	ss	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	healthy	healthy	JJ	JJ	_	16	amod	_	_
16	controls	control	NNS	NNS	_	11	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	5	det	_	_
3	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	5	compound	_	_
4	proliferation	proliferation	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	determined	determine	VBD	VBD	_	1	parataxis	_	_
9	reactivity	reactivity	NN	NN	_	8	dobj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	purified	purify	VBN	VBN	_	13	amod	_	_
12	recombinant	recombinant	JJ	JJ	_	13	amod	_	_
13	SSB	ssb	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	rSSB	rssb	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	20	20	CD	CD	_	19	nummod	_	_
19	patients	patient	NNS	NNS	_	9	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	SS	ss	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	19	19	CD	CD	_	24	nummod	_	_
24	controls	control	NNS	NNS	_	19	conj	_	_
25	.	.	.	.	_	1	punct	_	_

1	Specificity	specificity	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	using	use	VBG	VBG	_	3	xcomp	_	_
5	tetanus	tetanus	NN	NN	_	6	compound	_	_
6	toxoid	toxoid	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	endotoxin	endotoxin	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	3	3	CD	CD	_	13	nummod	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	autoantigens	autoantigen	NNS	NNS	_	6	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PBC.M2	pbc.m2	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	Sc170	sc170	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	GAD	gad	NN	NN	_	15	conj	_	_
21	)	)	-RRB-	-RRB-	_	15	punct	_	_
22	.	.	.	.	_	3	punct	_	_

1	Precursor	precursor	NN	NN	_	2	compound	_	_
2	frequency	frequency	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	calculated	calculate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	limiting	limit	VBG	VBG	_	4	advcl	_	_
7	dilution	dilution	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	6	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	HLA	hla	NN	NN	_	4	compound	_	_
2	Class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	dependency	dependency	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	investigated	investigate	VBN	VBN	_	0	root	_	_
7	using	use	VBG	VBG	_	6	xcomp	_	_
8	anti-Class	anti-class	JJ	JJ	_	11	amod	_	_
9	II	ii	CD	CD	_	11	nummod	_	_
10	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
11	antibodies	antibody	NNS	NNS	_	7	dobj	_	_
12	.	.	.	.	_	6	punct	_	_

1	HLA-DR	hla-dr	NN	NN	_	2	compound	_	_
2	typing	typing	NN	NN	_	7	nsubj	_	_
3	was	be	VBD	VBD	_	7	cop	_	_
4	by	by	IN	IN	_	7	case	_	_
5	polymerase	polymerase	NN	NN	_	7	compound	_	_
6	chain	chain	NN	NN	_	7	compound	_	_
7	reaction	reaction	NN	NN	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	sequence	sequence	NN	NN	_	12	compound	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	oligonucleotide	oligonucleotide	NN	NN	_	12	compound	_	_
12	typing	typing	NN	NN	_	7	conj	_	_
13	.	.	.	.	_	7	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Six	six	CD	CD	_	3	compound	_	_
2	of	of	IN	IN	_	3	advmod	_	_
3	20	20	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	10	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	SS	ss	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	10/19	10/19	CD	CD	_	9	nummod	_	_
9	controls	control	NNS	NNS	_	4	conj	_	_
10	proliferated	proliferate	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	La	la	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	rSSB	rssb	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	10	punct	_	_

1	Precursor	precursor	NN	NN	_	2	compound	_	_
2	frequency	frequency	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	anti-SSB	anti-ssb	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	1:77,040	1:77,040	CD	CD	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	1:115,000	1:115,000	CD	CD	_	8	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	2	2	CD	CD	_	14	nummod	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	subjects	subject	NNS	NNS	_	8	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	1:230,250	1:230,250	CD	CD	_	8	conj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	1:103,034	1:103,034	CD	CD	_	16	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	two	two	CD	CD	_	21	nummod	_	_
21	patients	patient	NNS	NNS	_	16	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	SS	ss	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Anti-HLA-DR	anti-hla-dr	NN	NN	_	2	nsubj	_	_
2	abrogated	abrogate	VBD	VBD	_	0	root	_	_
3	proliferation	proliferation	NN	NN	_	2	dobj	_	_
4	to	to	TO	TO	_	5	case	_	_
5	SSB	ssb	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	tetanus	tetanus	NN	NN	_	8	compound	_	_
8	toxoid	toxoid	NN	NN	_	5	conj	_	_
9	.	.	.	.	_	2	punct	_	_

1	Thirteen	thirteen	CD	CD	_	3	compound	_	_
2	of	of	IN	IN	_	3	advmod	_	_
3	15	15	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	12	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	SS	ss	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	4/17	4/17	CD	CD	_	9	nummod	_	_
9	controls	control	NNS	NNS	_	4	conj	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	HLA-DR3	hla-dr3	NN	NN	_	12	nmod:npmod	_	_
12	positive	positive	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	with	with	IN	IN	_	17	case	_	_
15	no	no	DT	DT	_	17	neg	_	_
16	apparent	apparent	JJ	JJ	_	17	amod	_	_
17	association	association	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HLA-DR3	hla-dr3	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	SSB	ssb	NN	NN	_	22	compound	_	_
22	reactivity	reactivity	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	controls	control	NNS	NNS	_	17	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Anti-La(SSB)	anti-la(ssb)	NN	NN	_	4	compound	_	_
2	specific	specific	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	occur	occur	VBP	VBP	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	proportion	proportion	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	controls	control	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	in	in	IN	IN	_	15	case	_	_
14	some	some	DT	DT	_	15	det	_	_
15	patients	patient	NNS	NNS	_	9	conj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	SS	ss	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	SSB	ssb	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	controls	control	NNS	NNS	_	6	nmod	_	_
9	remains	remain	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	defined	define	VBN	VBN	_	9	xcomp	_	_
13	.	.	.	.	_	9	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	represent	represent	VB	VB	_	0	root	_	_
4	immunoregulatory	immunoregulatory	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	further	further	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	26	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	a	a	DT	DT	_	16	det	_	_
16	comparison	comparison	NN	NN	_	9	conj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	those	those	DT	DT	_	16	nmod	_	_
19	found	find	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	21	case	_	_
21	patients	patient	NNS	NNS	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	SS	ss	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	9	punct	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	elucidate	elucidate	VB	VB	_	3	conj	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	immunoregulation	immunoregulation	NN	NN	_	26	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	the	the	DT	DT	_	31	det	_	_
31	derangements	derangement	NNS	NNS	_	28	conj	_	_
32	that	that	WDT	WDT	_	33	nsubj	_	_
33	lead	lead	VBP	VBP	_	31	acl:relcl	_	_
34	to	to	TO	TO	_	37	case	_	_
35	Sjogren	sjogren	NN	NN	_	37	nmod:poss	_	_
36	's	's	POS	POS	_	37	case	_	_
37	syndrome	syndrome	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Defective	defective	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	C	c	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	multidrug-resistant	multidrug-resistant	JJ	JJ	_	10	amod	_	_
9	HL-60	hl-60	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	confers	confer	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	reversible	reversible	JJ	JJ	_	14	amod	_	_
14	loss	loss	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	phorbol	phorbol	NN	NN	_	17	nmod:npmod	_	_
17	ester-induced	ester-induced	JJ	JJ	_	19	amod	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	HL-60	hl-60	NN	NN	_	10	compound	_	_
8	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
9	leukemia	leukemia	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	11	nsubj	_	_
11	differentiate	differentiate	VBP	VBP	_	4	ccomp	_	_
12	in	in	IN	IN	_	16	case	_	_
13	response	response	NN	NN	_	16	dep	_	_
14	to	to	TO	TO	_	16	case	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	esters	ester	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	event	event	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	induction	induction	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	c-jun	c-jun	NN	NN	_	12	compound	_	_
10	early	early	JJ	JJ	_	12	amod	_	_
11	response	response	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	appearance	appearance	NN	NN	_	6	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	phenotype	phenotype	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	vincristine-selected	vincristine-selected	JJ	JJ	_	12	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	multidrug	multidrug	JJ	JJ	_	9	dep	_	_
12	resistance	resistance	NN	NN	_	7	nmod	_	_
13	on	on	IN	IN	_	21	case	_	_
14	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	18	nmod:npmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	TPA	tpa	NN	NN	_	18	nmod:npmod	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	-induced	-induced	JJ	JJ	_	21	amod	_	_
19	HL-60	hl-60	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	7	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	multidrug-resistant	multidrug-resistant	JJ	JJ	_	7	amod	_	_
6	HL-60	hl-60	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	12	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	designated	designate	VBN	VBN	_	7	acl	_	_
10	HL-60/vinc	hl-60/vinc	NN	NN	_	9	xcomp	_	_
11	,	,	,	,	_	7	punct	_	_
12	fail	fail	VBP	VBP	_	3	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	respond	respond	VB	VB	_	12	xcomp	_	_
15	to	to	TO	TO	_	16	case	_	_
16	TPA	tpa	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	increase	increase	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	c-jun	c-jun	NN	NN	_	22	compound	_	_
22	transcripts	transcript	NNS	NNS	_	19	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	other	other	JJ	JJ	_	26	amod	_	_
25	phenotypic	phenotypic	JJ	JJ	_	26	amod	_	_
26	characteristics	characteristic	NNS	NNS	_	22	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	monocytic	monocytic	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	19	nmod	_	_
3	,	,	,	,	_	19	punct	_	_
4	treatment	treatment	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	HL-60/vinc	hl-60/vinc	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	okadaic	okadaic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	17	case	_	_
15	serine/threonine	serine/threonine	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	phosphatases	phosphatase	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	induces	induce	VBZ	VBZ	_	0	root	_	_
20	c-jun	c-jun	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	arrest	arrest	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	expression	expression	NN	NN	_	21	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	c-fms	c-fms	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	19	punct	_	_

1	Studies	study	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	performed	perform	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	12	case	_	_
6	an	a	DT	DT	_	12	det	_	_
7	HL-60/vinc	hl-60/vinc	NN	NN	_	8	dep	_	_
8	revertant	revertant	NN	NN	_	12	amod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HL-60/vinc/R	hl-60/vinc/r	NN	NN	_	8	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	line	line	NN	NN	_	4	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	has	have	VBZ	VBZ	_	15	aux	_	_
15	regained	regain	VBN	VBN	_	12	acl:relcl	_	_
16	partial	partial	JJ	JJ	_	17	amod	_	_
17	sensitivity	sensitivity	NN	NN	_	15	dobj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	vincristine	vincristine	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	21	nsubj	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	HL-60/vinc/R	hl-60/vinc/r	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	respond	respond	VBP	VBP	_	2	ccomp	_	_
7	to	to	TO	TO	_	8	case	_	_
8	TPA	tpa	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	induction	induction	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	phenotype	phenotype	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	10	cc	_	_
18	c-jun	c-jun	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	10	conj	_	_
20	,	,	,	,	_	10	punct	_	_
21	suggests	suggest	VBZ	VBZ	_	0	root	_	_
22	that	that	IN	IN	_	27	mark	_	_
23	c-jun	c-jun	NN	NN	_	24	compound	_	_
24	induction	induction	NN	NN	_	27	nsubj	_	_
25	is	be	VBZ	VBZ	_	27	cop	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	obligatory	obligatory	JJ	JJ	_	21	ccomp	_	_
28	for	for	IN	IN	_	30	case	_	_
29	monocytic	monocytic	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	21	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	jun-B	jun-b	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	fra-1	fra-1	NN	NN	_	7	conj	_	_
10	genes	gene	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	4	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	TPA	tpa	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	HL-60/vinc	hl-60/vinc	NN	NN	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HL-60/vinc/R	hl-60/vinc/r	NN	NN	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	12	nmod	_	_
21	,	,	,	,	_	4	punct	_	_
22	whereas	whereas	IN	IN	_	4	dep	_	_
23	c-fos	c-fos	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	attenuated	attenuate	VBN	VBN	_	4	parataxis	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	HL-60/vinc	hl-60/vinc	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	3	mark	_	_
2	TPA	tpa	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	12	advcl	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	C	c	NN	NN	_	3	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PKC	pkc	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	examined	examine	VBD	VBD	_	0	root	_	_
13	translocation	translocation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	PKC	pkc	NN	NN	_	13	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cytosol	cytosol	NN	NN	_	13	nmod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	membrane	membrane	NN	NN	_	22	compound	_	_
22	fraction	fraction	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	HL-60	hl-60	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	HL-60/vinc/R	hl-60/vinc/r	NN	NN	_	2	conj	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	16	advcl	_	_
7	translocation	translocation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	PKC	pkc	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	16	punct	_	_
12	this	this	DT	DT	_	14	det	_	_
13	subcellular	subcellular	JJ	JJ	_	14	amod	_	_
14	redistribution	redistribution	NN	NN	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	undetectable	undetectable	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	HL-60/vinc	hl-60/vinc	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	Activity	activity	NN	NN	_	16	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	mitogen-activated	mitogen-activated	JJ	JJ	_	7	amod	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	1	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	associated	associated	JJ	JJ	_	10	amod	_	_
10	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	c-Jun	c-jun	NN	NN	_	13	compound	_	_
13	Y-peptide	y-peptide	NN	NN	_	10	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	markedly	markedly	RB	RB	_	16	advmod	_	_
16	diminished	diminish	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	20	case	_	_
18	TPA-treated	tpa-treated	JJ	JJ	_	20	amod	_	_
19	HL-60/vinc	hl-60/vinc	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	but	but	CC	CC	_	16	cc	_	_
23	not	not	RB	RB	_	28	neg	_	_
24	in	in	IN	IN	_	28	case	_	_
25	response	response	NN	NN	_	28	dep	_	_
26	to	to	TO	TO	_	28	case	_	_
27	okadaic	okadaic	JJ	JJ	_	28	amod	_	_
28	acid	acid	NN	NN	_	16	conj	_	_
29	.	.	.	.	_	16	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	vincristine	vincristine	NN	NN	_	9	compound	_	_
9	resistance	resistance	NN	NN	_	10	nsubj	_	_
10	confers	confer	VBZ	VBZ	_	6	ccomp	_	_
11	insensitivity	insensitivity	NN	NN	_	10	dobj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	TPA-induced	tpa-induced	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	include	include	VB	VB	_	10	conj	_	_
18	defects	defect	NNS	NNS	_	17	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	PKC-mediated	pkc-mediated	JJ	JJ	_	22	amod	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	events	event	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	induction	induction	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	jun/fos	jun/fos	NN	NN	_	30	compound	_	_
27	early	early	JJ	JJ	_	30	amod	_	_
28	response	response	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	contribution	contribution	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	herpes	herpes	NN	NN	_	7	compound	_	_
5	simplex	simplex	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	2	nmod	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	products	product	NNS	NNS	_	7	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	10	conj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activation	activation	NN	NN	_	2	nmod	_	_
17	of	of	IN	IN	_	23	case	_	_
18	human	human	JJ	JJ	_	23	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	23	compound	_	_
20	virus	virus	NN	NN	_	23	compound	_	_
21	type	type	NN	NN	_	23	compound	_	_
22	1	1	CD	CD	_	23	nummod	_	_
23	provirus	provirus	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	infection	infection	NN	NN	_	16	nsubj	_	_
7	with	with	IN	IN	_	11	case	_	_
8	herpes	herpes	NN	NN	_	11	compound	_	_
9	simplex	simplex	NN	NN	_	11	compound	_	_
10	virus	virus	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	6	nmod	_	_
12	1	1	CD	CD	_	11	nummod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HSV-1	hsv-1	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	activates	activate	VBZ	VBZ	_	4	ccomp	_	_
17	expression	expression	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	28	case	_	_
19	the	the	DT	DT	_	28	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	immunodeficiency	immunodeficiency	NN	NN	_	23	compound	_	_
22	virus	virus	NN	NN	_	23	compound	_	_
23	type	type	NN	NN	_	28	compound	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HIV-1	hiv-1	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	provirus	provirus	NN	NN	_	17	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	17	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	provirus	provirus	NN	NN	_	1	nmod	_	_
6	correlated	correlate	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	binding	binding	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	55-	55-	CD	CD	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	85-kDa	85-kda	JJ	JJ	_	13	conj	_	_
16	proteins	protein	NNS	NNS	_	11	nmod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	kappa	kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	enhancer	enhancer	NN	NN	_	11	nmod	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	binding	binding	NN	NN	_	11	conj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	50-kDa	50-kda	JJ	JJ	_	28	amod	_	_
27	HLP-1	hlp-1	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	23	nmod	_	_
29	to	to	TO	TO	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	LBP-1	lbp-1	NN	NN	_	32	compound	_	_
32	sequences	sequence	NNS	NNS	_	23	nmod	_	_
33	of	of	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	HIV-1	hiv-1	NN	NN	_	38	compound	_	_
36	long	long	JJ	JJ	_	38	amod	_	_
37	terminal	terminal	JJ	JJ	_	38	amod	_	_
38	repeat	repeat	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	Further	further	RB	RB	_	2	advmod	_	_
2	examination	examination	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	system	system	NN	NN	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	7	aux	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	21	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	inhibition	inhibition	NN	NN	_	21	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	HSV-1	hsv-1	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	antiviral	antiviral	JJ	JJ	_	18	amod	_	_
17	drug	drug	NN	NN	_	18	compound	_	_
18	acyclovir	acyclovir	NN	NN	_	10	nmod	_	_
19	does	do	VBZ	VBZ	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	inhibit	inhibit	VB	VB	_	7	ccomp	_	_
22	HSV-1-mediated	hsv-1-mediated	JJ	JJ	_	23	amod	_	_
23	induction	induction	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
26	provirus	provirus	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	9	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	HLP-1	hlp-1	NN	NN	_	5	conj	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activities	activity	NNS	NNS	_	12	nsubjpass	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	substantially	substantially	RB	RB	_	12	advmod	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	acyclovir-treated	acyclovir-treated	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	transient-transfection	transient-transfection	JJ	JJ	_	4	amod	_	_
4	assay	assay	NN	NN	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	ICP0	icp0	NN	NN	_	12	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	6	cc	_	_
10	ICP4	icp4	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	activated	activate	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	19	det	_	_
14	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
15	long	long	JJ	JJ	_	19	amod	_	_
16	terminal	terminal	JJ	JJ	_	19	amod	_	_
17	repeat	repeat	NN	NN	_	19	compound	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	12	dobj	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	effect	effect	NN	NN	_	27	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	ICP0	icp0	NN	NN	_	22	nmod	_	_
25	was	be	VBD	VBD	_	27	auxpass	_	_
26	greatly	greatly	RB	RB	_	27	advmod	_	_
27	enhanced	enhance	VBN	VBN	_	12	conj	_	_
28	in	in	IN	IN	_	36	case	_	_
29	the	the	DT	DT	_	36	dep	_	_
30	presence	presence	NN	NN	_	36	dep	_	_
31	of	of	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	proteins	protein	NNS	NNS	_	27	nmod	_	_
37	,	,	,	,	_	27	punct	_	_
38	suggesting	suggest	VBG	VBG	_	27	xcomp	_	_
39	that	that	IN	IN	_	45	mark	_	_
40	induction	induction	NN	NN	_	45	nsubj	_	_
41	of	of	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	HIV-1	hiv-1	NN	NN	_	44	compound	_	_
44	provirus	provirus	NN	NN	_	40	nmod	_	_
45	involves	involve	VBZ	VBZ	_	38	ccomp	_	_
46	cooperation	cooperation	NN	NN	_	45	dobj	_	_
47	between	between	IN	IN	_	51	case	_	_
48	the	the	DT	DT	_	51	det	_	_
49	HSV-1-activated	hsv-1-activated	JJ	JJ	_	51	amod	_	_
50	cellular	cellular	JJ	JJ	_	51	amod	_	_
51	factor	factor	NN	NN	_	46	nmod	_	_
52	,	,	,	,	_	51	punct	_	_
53	NF-kappa	nf-kappa	NN	NN	_	54	compound	_	_
54	B	b	NN	NN	_	51	appos	_	_
55	,	,	,	,	_	51	punct	_	_
56	and	and	CC	CC	_	51	cc	_	_
57	the	the	DT	DT	_	59	det	_	_
58	virus-encoded	virus-encoded	JJ	JJ	_	59	amod	_	_
59	transactivator	transactivator	NN	NN	_	51	conj	_	_
60	,	,	,	,	_	59	punct	_	_
61	ICP0	icp0	NN	NN	_	59	appos	_	_
62	.	.	.	.	_	12	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	mononuclear	mononuclear	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	sepsis	sepsis	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GR	gr	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	hormone-binding	hormone-binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	studied	study	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	whole-cell	whole-cell	JJ	JJ	_	13	amod	_	_
13	method	method	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	MNC	mnc	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	from	from	IN	IN	_	22	case	_	_
21	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
22	blood	blood	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	7	7	CD	CD	_	25	nummod	_	_
25	patients	patient	NNS	NNS	_	22	nmod	_	_
26	during	during	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	hemodynamic	hemodynamic	JJ	JJ	_	30	amod	_	_
29	compensatory	compensatory	JJ	JJ	_	30	amod	_	_
30	phase	phase	NN	NN	_	9	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	sepsis	sepsis	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	4	4	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	aux	_	_
4	receiving	receive	VBG	VBG	_	0	root	_	_
5	dopamine	dopamine	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	10	nsubj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affect	affect	VB	VB	_	5	acl:relcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	GR	gr	NN	NN	_	13	compound	_	_
13	count	count	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	6	nmod:poss	_	_
3	'	'	POS	POS	_	2	case	_	_
4	plasma	plasma	NN	NN	_	6	compound	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	concentrations	concentration	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	normal	normal	JJ	JJ	_	0	root	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	slightly	slightly	RB	RB	_	11	advmod	_	_
11	elevated	elevated	JJ	JJ	_	8	conj	_	_
12	.	.	.	.	_	8	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	wide	wide	JJ	JJ	_	4	amod	_	_
4	range	range	NN	NN	_	19	nmod	_	_
5	,	,	,	,	_	19	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	mean	mean	NN	NN	_	8	compound	_	_
8	GR	gr	NN	NN	_	19	nsubj	_	_
9	count	count	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	affinity	affinity	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	MNC	mnc	NN	NN	_	8	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	septic	septic	JJ	JJ	_	16	amod	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	differ	differ	VB	VB	_	0	root	_	_
20	from	from	IN	IN	_	21	case	_	_
21	those	those	DT	DT	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	controls	control	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	suggesting	suggest	VBG	VBG	_	19	xcomp	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	glucocorticoids	glucocorticoid	NNS	NNS	_	32	nsubj	_	_
29	could	could	MD	MD	_	32	aux	_	_
30	still	still	RB	RB	_	32	advmod	_	_
31	be	be	VB	VB	_	32	cop	_	_
32	effective	effective	JJ	JJ	_	26	ccomp	_	_
33	in	in	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	hemodynamic	hemodynamic	JJ	JJ	_	37	amod	_	_
36	compensatory	compensatory	JJ	JJ	_	37	amod	_	_
37	phase	phase	NN	NN	_	32	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	sepsis	sepsis	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	19	punct	_	_

1	Dependence	dependence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	proliferative	proliferative	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	erythropoietin	erythropoietin	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	13	case	_	_
9	an	a	DT	DT	_	13	det	_	_
10	established	established	JJ	JJ	_	13	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	13	amod	_	_
12	differentiation	differentiation	NN	NN	_	13	compound	_	_
13	program	program	NN	NN	_	1	nmod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	1	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	UT-7	ut-7	NN	NN	_	19	appos	_	_
22	.	.	.	.	_	1	punct	_	_

1	Erythroid	erythroid	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	3	nsubj	_	_
3	involves	involve	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	erythroid-specific	erythroid-specific	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	most	most	JJS	JJS	_	37	nsubjpass	_	_
14	of	of	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	including	include	VBG	VBG	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	globin	globin	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	13	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	erythropoietin	erythropoietin	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Epo-R	epo-r	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	gene	gene	NN	NN	_	20	conj	_	_
29	,	,	,	,	_	13	punct	_	_
30	are	be	VBP	VBP	_	37	auxpass	_	_
31	,	,	,	,	_	37	punct	_	_
32	at	at	IN	IN	_	35	advmod	_	_
33	least	least	JJS	JJS	_	32	mwe	_	_
34	in	in	IN	IN	_	35	case	_	_
35	part	part	NN	NN	_	37	nmod	_	_
36	,	,	,	,	_	37	punct	_	_
37	regulated	regulate	VBN	VBN	_	11	acl:relcl	_	_
38	by	by	IN	IN	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	transcription	transcription	NN	NN	_	42	compound	_	_
41	factor	factor	NN	NN	_	42	compound	_	_
42	GATA-1	gata-1	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	understand	understand	VB	VB	_	24	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	relationship	relationship	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	4	punct	_	_
8	if	if	IN	IN	_	9	mark	_	_
9	any	any	DT	DT	_	4	advcl	_	_
10	,	,	,	,	_	4	punct	_	_
11	between	between	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GATA-1	gata-1	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	response	response	NN	NN	_	12	conj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	Epo	epo	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	12	conj	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	analyzed	analyze	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	GATA-1	gata-1	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	Epo-R	epo-r	NN	NN	_	28	conj	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	globin	globin	NN	NN	_	33	compound	_	_
33	genes	gene	NNS	NNS	_	28	conj	_	_
34	in	in	IN	IN	_	39	case	_	_
35	an	a	DT	DT	_	39	det	_	_
36	Epo-dependent	epo-dependent	JJ	JJ	_	39	amod	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	26	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	UT-7	ut-7	NN	NN	_	42	compound	_	_
42	Epo	epo	NN	NN	_	39	appos	_	_
43	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	compared	compare	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	those	those	DT	DT	_	4	nmod	_	_
7	obtained	obtain	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	19	case	_	_
9	the	the	DT	DT	_	19	det	_	_
10	parental	parental	JJ	JJ	_	19	amod	_	_
11	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	12	amod	_	_
12	colony-stimulating	colony-stimulating	JJ	JJ	_	17	dep	_	_
13	factor	factor	NN	NN	_	17	nmod:npmod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	GM-CSF	gm-csf	NN	NN	_	17	nmod:npmod	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	-dependent	-dependent	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	7	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	UT-7	ut-7	NN	NN	_	19	appos	_	_
22	,	,	,	,	_	19	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	has	have	VBZ	VBZ	_	19	acl:relcl	_	_
25	a	a	DT	DT	_	28	det	_	_
26	predominantly	predominantly	RB	RB	_	27	advmod	_	_
27	megakaryoblastic	megakaryoblastic	JJ	JJ	_	28	amod	_	_
28	phenotype	phenotype	NN	NN	_	24	dobj	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	unable	unable	JJ	JJ	_	24	conj	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	proliferate	proliferate	VB	VB	_	31	xcomp	_	_
34	continuously	continuously	RB	RB	_	33	advmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	dep	_	_
37	presence	presence	NN	NN	_	39	dep	_	_
38	of	of	IN	IN	_	39	case	_	_
39	Epo	epo	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	UT-7	ut-7	NN	NN	_	2	compound	_	_
2	Epo	epo	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	UT-7	ut-7	NN	NN	_	2	conj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	similar	similar	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	GATA-1	gata-1	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	lines	line	NNS	NNS	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	comparable	comparable	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Epo-R	epo-r	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	while	while	IN	IN	_	24	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	number	number	NN	NN	_	24	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	Epo-binding	epo-binding	JJ	JJ	_	16	amod	_	_
16	sites	site	NNS	NNS	_	13	nmod	_	_
17	on	on	IN	IN	_	20	case	_	_
18	UT-7	ut-7	NN	NN	_	20	compound	_	_
19	Epo	epo	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	was	be	VBD	VBD	_	24	cop	_	_
22	one-sixth	one-sixth	CD	CD	_	24	nummod	_	_
23	the	the	DT	DT	_	24	det	_	_
24	number	number	NN	NN	_	5	advcl	_	_
25	of	of	IN	IN	_	27	case	_	_
26	UT-7	ut-7	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	2400	2400	CD	CD	_	24	dep	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	3	3	CD	CD	_	29	conj	_	_
32	vs.	vs.	CC	CC	_	29	cc	_	_
33	13,800	13,800	CD	CD	_	29	conj	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	300	300	CD	CD	_	33	conj	_	_
36	)	)	-RRB-	-RRB-	_	29	punct	_	_
37	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	sites	site	NNS	NNS	_	5	nmod	_	_
9	could	could	MD	MD	_	13	aux	_	_
10	be	be	VB	VB	_	13	cop	_	_
11	due	due	JJ	JJ	_	13	case	_	_
12	to	to	TO	TO	_	11	mwe	_	_
13	differences	difference	NNS	NNS	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	surface	surface	NN	NN	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	23	punct	_	_
18	UT-7	ut-7	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	23	nsubj	_	_
20	are	be	VBP	VBP	_	23	cop	_	_
21	20	20	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	23	nmod:npmod	_	_
23	smaller	smaller	JJR	JJR	_	16	dep	_	_
24	than	than	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	parental	parental	JJ	JJ	_	28	amod	_	_
27	UT-7	ut-7	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	)	)	-RRB-	-RRB-	_	23	punct	_	_
30	or	or	CC	CC	_	16	cc	_	_
31	in	in	IN	IN	_	33	case	_	_
32	receptor	receptor	NN	NN	_	33	compound	_	_
33	turnover	turnover	NN	NN	_	16	conj	_	_
34	.	.	.	.	_	13	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	Northern	northern	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	UT-7	ut-7	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	expressed	express	VBD	VBD	_	0	root	_	_
8	detectable	detectable	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	beta-	beta-	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	gamma-globin	gamma-globin	NN	NN	_	11	conj	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	11	cc	_	_
16	alpha-globin	alpha-globin	NN	NN	_	11	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	UT-7	ut-7	NN	NN	_	6	compound	_	_
5	Epo	epo	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	expressed	express	VBD	VBD	_	0	root	_	_
8	alpha-globin	alpha-globin	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	higher	higher	JJR	JJR	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	gamma-globin	gamma-globin	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	5-fold	5-fold	JJ	JJ	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	beta-globin	beta-globin	NN	NN	_	13	conj	_	_
19	(	(	-LRB-	-LRB-	_	24	punct	_	_
20	from	from	IN	IN	_	21	case	_	_
21	barely	barely	RB	RB	_	24	dep	_	_
22	to	to	TO	TO	_	23	case	_	_
23	clearly	clearly	RB	RB	_	21	nmod	_	_
24	detectable	detectable	JJ	JJ	_	18	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	7	punct	_	_

1	Globin	globin	NN	NN	_	2	compound	_	_
2	chains	chain	NNS	NNS	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	alpha	alpha	NN	NN	_	2	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	beta	beta	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	gamma	gamma	NN	NN	_	4	conj	_	_
9	)	)	-RRB-	-RRB-	_	4	punct	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	clearly	clearly	RB	RB	_	12	advmod	_	_
12	detectable	detectable	JJ	JJ	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	affinity	affinity	NN	NN	_	15	compound	_	_
15	chromatography	chromatography	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	UT-7	ut-7	NN	NN	_	18	compound	_	_
18	Epo	epo	NN	NN	_	12	nmod	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	18	cc	_	_
21	in	in	IN	IN	_	23	case	_	_
22	UT-7	ut-7	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	frequency	frequency	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	expressed	express	VBD	VBD	_	5	acl:relcl	_	_
8	beta-	beta-	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	gamma-globin	gamma-globin	NN	NN	_	11	compound	_	_
11	genes	gene	NNS	NNS	_	8	conj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	populations	population	NNS	NNS	_	7	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	measured	measure	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	20	case	_	_
20	immunofluorescence	immunofluorescence	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	25	case	_	_
22	beta-	beta-	NN	NN	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	gamma-specific	gamma-specific	JJ	JJ	_	22	conj	_	_
25	antibodies	antibody	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gamma-positive	gamma-positive	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
8	fluorescence	fluorescence	NN	NN	_	9	compound	_	_
9	intensity	intensity	NN	NN	_	2	conj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	higher	higher	JJR	JJR	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	UT-7	ut-7	NN	NN	_	14	compound	_	_
14	Epo	epo	NN	NN	_	11	nmod	_	_
15	than	than	IN	IN	_	18	case	_	_
16	in	in	IN	IN	_	18	case	_	_
17	UT-7	ut-7	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	advcl	_	_
19	(	(	-LRB-	-LRB-	_	11	punct	_	_
20	0	0	CD	CD	_	22	compound	_	_
21	to	to	TO	TO	_	22	dep	_	_
22	17	17	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	11	dep	_	_
24	barely	barely	RB	RB	_	25	advmod	_	_
25	positive	positive	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	dep	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	23	23	CD	CD	_	30	compound	_	_
29	to	to	TO	TO	_	30	dep	_	_
30	40	40	CD	CD	_	31	nummod	_	_
31	%	%	NN	NN	_	23	conj	_	_
32	clearly	clearly	RB	RB	_	33	advmod	_	_
33	positive	positive	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	dep	_	_
35	,	,	,	,	_	23	punct	_	_
36	respectively	respectively	RB	RB	_	23	advmod	_	_
37	)	)	-RRB-	-RRB-	_	11	punct	_	_
38	,	,	,	,	_	11	punct	_	_
39	indicating	indicate	VBG	VBG	_	11	xcomp	_	_
40	that	that	IN	IN	_	55	mark	_	_
41	the	the	DT	DT	_	42	det	_	_
42	increase	increase	NN	NN	_	55	nsubj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	globin	globin	NN	NN	_	45	compound	_	_
45	mRNA	mrna	NN	NN	_	42	nmod	_	_
46	observed	observe	VBN	VBN	_	45	acl	_	_
47	in	in	IN	IN	_	49	case	_	_
48	UT-7	ut-7	NN	NN	_	49	compound	_	_
49	Epo	epo	NN	NN	_	46	nmod	_	_
50	is	be	VBZ	VBZ	_	55	cop	_	_
51	due	due	JJ	JJ	_	55	case	_	_
52	to	to	TO	TO	_	51	mwe	_	_
53	both	both	CC	CC	_	55	cc:preconj	_	_
54	an	a	DT	DT	_	55	det	_	_
55	increase	increase	NN	NN	_	39	ccomp	_	_
56	of	of	IN	IN	_	58	case	_	_
57	gene	gene	NN	NN	_	58	compound	_	_
58	expression	expression	NN	NN	_	55	nmod	_	_
59	per	per	IN	IN	_	60	case	_	_
60	cell	cell	NN	NN	_	58	nmod	_	_
61	and	and	CC	CC	_	55	cc	_	_
62	an	a	DT	DT	_	63	det	_	_
63	increase	increase	NN	NN	_	55	conj	_	_
64	in	in	IN	IN	_	65	case	_	_
65	numbers	number	NNS	NNS	_	63	nmod	_	_
66	of	of	IN	IN	_	67	case	_	_
67	cells	cell	NNS	NNS	_	65	nmod	_	_
68	containing	contain	VBG	VBG	_	67	acl	_	_
69	gamma-globin	gamma-globin	NN	NN	_	68	dobj	_	_
70	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GATA-1	gata-1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	Epo-R	epo-r	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	globin	globin	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	4	conj	_	_
10	expressed	express	VBN	VBN	_	4	acl	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affected	affect	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	24-hour	24-hour	JJ	JJ	_	17	amod	_	_
17	incubation	incubation	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	either	either	CC	CC	_	21	dep	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	17	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	Epo	epo	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	GM-CSF	gm-csf	NN	NN	_	23	conj	_	_
26	or	or	CC	CC	_	23	cc	_	_
27	interleukin-3	interleukin-3	NN	NN	_	23	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	IL-3	il-3	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	13	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	400	400	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	macrophage	macrophage	NN	NN	_	8	compound	_	_
6	colony-stimulating	colony-stimulating	JJ	JJ	_	8	amod	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-2	il-2	NN	NN	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	secretion	secretion	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	bioactive	bioactive	JJ	JJ	_	20	amod	_	_
17	macrophage	macrophage	NN	NN	_	20	compound	_	_
18	colony-stimulating	colony-stimulating	JJ	JJ	_	20	amod	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	14	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	involves	involve	VBZ	VBZ	_	12	conj	_	_
25	activation	activation	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	transcription	transcription	NN	NN	_	31	compound	_	_
29	factor	factor	NN	NN	_	31	compound	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	peripheral	peripheral	JJ	JJ	_	3	amod	_	_
3	blood	blood	NN	NN	_	9	nsubj	_	_
4	monocytes	monocyte	NNS	NNS	_	3	dep	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Mo	mo	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	display	display	VBP	VBP	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	beta-chain	beta-chain	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	receptor	receptor	NN	NN	_	11	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	IL-2	il-2	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	whereas	whereas	IN	IN	_	9	dep	_	_
19	expression	expression	NN	NN	_	26	nsubj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-2R	il-2r	NN	NN	_	23	compound	_	_
23	alpha-chain	alpha-chain	NN	NN	_	19	nmod	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	constitutive	constitutive	JJ	JJ	_	9	parataxis	_	_
27	but	but	CC	CC	_	26	cc	_	_
28	inducible	inducible	JJ	JJ	_	26	conj	_	_
29	with	with	IN	IN	_	30	case	_	_
30	IL-2	il-2	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	binding	binding	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	IL-2	il-2	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	site	site	NN	NN	_	5	nmod	_	_
13	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	24	case	_	_
18	the	the	DT	DT	_	24	det	_	_
19	macrophage	macrophage	NN	NN	_	20	compound	_	_
20	CSF	csf	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	M-CSF	m-csf	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	gene	gene	NN	NN	_	16	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	Mo	mo	NN	NN	_	16	nmod	_	_
27	resulting	result	VBG	VBG	_	16	acl	_	_
28	in	in	IN	IN	_	29	case	_	_
29	accumulation	accumulation	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	M-CSF	m-csf	NN	NN	_	32	compound	_	_
32	mRNA	mrna	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	subsequent	subsequent	JJ	JJ	_	35	amod	_	_
35	release	release	NN	NN	_	29	conj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	bioactive	bioactive	JJ	JJ	_	39	amod	_	_
38	M-CSF	m-csf	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	35	nmod	_	_
40	as	as	IN	IN	_	41	mark	_	_
41	demonstrated	demonstrate	VBN	VBN	_	29	dep	_	_
42	by	by	IN	IN	_	43	case	_	_
43	ELISA	elisa	NN	NN	_	41	nmod	_	_
44	and	and	CC	CC	_	16	cc	_	_
45	inhibition	inhibition	NN	NN	_	16	conj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	IL-2	il-2	NN	NN	_	48	nmod:npmod	_	_
48	induced	induced	JJ	JJ	_	49	amod	_	_
49	release	release	NN	NN	_	45	nmod	_	_
50	of	of	IN	IN	_	53	case	_	_
51	an	a	DT	DT	_	53	det	_	_
52	activity-stimulating	activity-stimulating	JJ	JJ	_	53	amod	_	_
53	growth	growth	NN	NN	_	49	nmod	_	_
54	of	of	IN	IN	_	56	case	_	_
55	monocyte-type	monocyte-type	JJ	JJ	_	56	amod	_	_
56	colonies	colony	NNS	NNS	_	53	nmod	_	_
57	by	by	IN	IN	_	61	case	_	_
58	a	a	DT	DT	_	61	det	_	_
59	neutralizing	neutralize	VBG	VBG	_	61	amod	_	_
60	anti-M-CSF	anti-m-csf	JJ	JJ	_	61	amod	_	_
61	antibody	antibody	NN	NN	_	45	nmod	_	_
62	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	M-CSF	m-csf	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	IL-2	il-2	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	preceded	precede	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	enhanced	enhance	VBN	VBN	_	14	amod	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	transcription	transcription	NN	NN	_	20	compound	_	_
18	factor	factor	NN	NN	_	20	compound	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	14	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	recognition	recognition	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	14	nmod	_	_
25	in	in	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	5'	5'	JJ	JJ	_	30	amod	_	_
28	regulatory	regulatory	JJ	JJ	_	30	amod	_	_
29	enhancer	enhancer	NN	NN	_	30	compound	_	_
30	region	region	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	M-CSF	m-csf	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	using	use	VBG	VBG	_	22	advcl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	heterologous	heterologous	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	herpes	herpes	NN	NN	_	10	compound	_	_
9	thymidine	thymidine	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	6	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	construct	construct	NN	NN	_	3	dobj	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	18	det	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	consensus	consensus	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	13	dobj	_	_
19	,	,	,	,	_	22	punct	_	_
20	it	it	PRP	PRP	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	0	root	_	_
23	that	that	IN	IN	_	33	mark	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	binding	binding	NN	NN	_	33	nsubj	_	_
27	by	by	IN	IN	_	32	case	_	_
28	an	a	DT	DT	_	32	det	_	_
29	IL-2-induced	il-2-induced	JJ	JJ	_	32	amod	_	_
30	monocyte-derived	monocyte-derived	JJ	JJ	_	32	amod	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	protein	protein	NN	NN	_	26	nmod	_	_
33	confers	confer	VBZ	VBZ	_	22	ccomp	_	_
34	reporter	reporter	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	41	compound	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	growth	growth	NN	NN	_	39	compound	_	_
39	hormone	hormone	NN	NN	_	35	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	activity	activity	NN	NN	_	33	dobj	_	_
42	.	.	.	.	_	22	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	IL-2	il-2	NN	NN	_	9	nsubj	_	_
9	induces	induce	VBZ	VBZ	_	6	ccomp	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	M-CSF	m-csf	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	blood-derived	blood-derived	JJ	JJ	_	17	amod	_	_
17	Mo	mo	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	provide	provide	VBP	VBP	_	6	conj	_	_
20	evidence	evidence	NN	NN	_	19	dobj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	involvement	involvement	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	regulation	regulation	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	gene	gene	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Comparative	comparative	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFAT	nfat	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	4	dep	_	_
8	of	of	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	)	)	-RRB-	-RRB-	_	7	punct	_	_
13	complex	complex	JJ	JJ	_	4	amod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	T	t	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	B	b	NN	NN	_	16	conj	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NFAT	nfat	NN	NN	_	2	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activator	activator	NN	NN	_	0	root	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	binds	bind	VBZ	VBZ	_	13	acl:relcl	_	_
16	to	to	TO	TO	_	17	case	_	_
17	sequences	sequence	NNS	NNS	_	15	nmod	_	_
18	in	in	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	interleukin-2	interleukin-2	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IL-2	il-2	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	promoter	promoter	NN	NN	_	17	nmod	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	thought	think	VBN	VBN	_	13	conj	_	_
28	to	to	TO	TO	_	31	mark	_	_
29	be	be	VB	VB	_	31	cop	_	_
30	largely	largely	RB	RB	_	31	advmod	_	_
31	responsible	responsible	JJ	JJ	_	27	xcomp	_	_
32	for	for	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	T	t	NN	NN	_	35	nmod:npmod	_	_
35	cell-specific	cell-specific	JJ	JJ	_	36	amod	_	_
36	inducibility	inducibility	NN	NN	_	31	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	IL-2	il-2	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	13	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSA	emsa	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	17	mark	_	_
10	specific	specific	JJ	JJ	_	13	amod	_	_
11	NFAT	nfat	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	17	nsubjpass	_	_
14	could	could	MD	MD	_	17	aux	_	_
15	also	also	RB	RB	_	17	advmod	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	8	ccomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	B	b	NN	NN	_	5	compound	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	NFAT	nfat	NN	NN	_	5	compound	_	_
5	complex	complex	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	11	punct	_	_
7	however	however	RB	RB	_	11	advmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	functional	functional	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	since	since	IN	IN	_	15	mark	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	failed	fail	VBD	VBD	_	11	advcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	activate	activate	VB	VB	_	15	xcomp	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	from	from	IN	IN	_	27	case	_	_
20	an	a	DT	DT	_	27	det	_	_
21	NFAT-driven	nfat-driven	JJ	JJ	_	27	amod	_	_
22	chloramphenicol	chloramphenicol	NN	NN	_	23	compound	_	_
23	acetyltransferase	acetyltransferase	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CAT	cat	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	construct	construct	NN	NN	_	18	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Competition	competition	NN	NN	_	12	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	AP-1	ap-1	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	with	with	IN	IN	_	11	case	_	_
8	anti-Jun	anti-jun	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	anti-Fos	anti-fos	JJ	JJ	_	8	conj	_	_
11	antibodies	antibody	NNS	NNS	_	5	conj	_	_
12	abolished	abolish	VBD	VBD	_	0	root	_	_
13	binding	binding	NN	NN	_	12	dobj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	NFAT	nfat	NN	NN	_	17	compound	_	_
17	motif	motif	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	T	t	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	B	b	NN	NN	_	20	conj	_	_
23	cells	cell	NNS	NNS	_	13	nmod	_	_
24	,	,	,	,	_	12	punct	_	_
25	indicating	indicate	VBG	VBG	_	12	advcl	_	_
26	that	that	IN	IN	_	31	mark	_	_
27	Jun	jun	NN	NN	_	31	nsubj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	Fos	fos	NN	NN	_	27	conj	_	_
30	are	be	VBP	VBP	_	31	cop	_	_
31	critical	critical	JJ	JJ	_	25	ccomp	_	_
32	for	for	IN	IN	_	35	case	_	_
33	NFAT	nfat	NN	NN	_	35	compound	_	_
34	complex	complex	NN	NN	_	35	compound	_	_
35	formation	formation	NN	NN	_	31	nmod	_	_
36	in	in	IN	IN	_	39	case	_	_
37	both	both	DT	DT	_	39	det	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	types	type	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	12	punct	_	_

1	Purified	purify	VBN	VBN	_	6	amod	_	_
2	recombinant	recombinant	JJ	JJ	_	6	amod	_	_
3	Jun	jun	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Fos	fos	NN	NN	_	3	conj	_	_
6	proteins	protein	NNS	NNS	_	7	nsubj	_	_
7	failed	fail	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	bind	bind	VB	VB	_	7	xcomp	_	_
10	directly	directly	RB	RB	_	9	advmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NFAT	nfat	NN	NN	_	14	compound	_	_
14	motif	motif	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	when	when	WRB	WRB	_	4	advmod	_	_
4	combined	combine	VBN	VBN	_	22	advcl	_	_
5	with	with	IN	IN	_	11	case	_	_
6	unstimulated	unstimulated	JJ	JJ	_	11	amod	_	_
7	B	b	NN	NN	_	11	compound	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	T	t	NN	NN	_	7	conj	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	extracts	extract	NNS	NNS	_	4	nmod	_	_
12	,	,	,	,	_	22	punct	_	_
13	full-length	full-length	JJ	JJ	_	20	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	but	but	CC	CC	_	13	cc	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	truncated	truncate	VBN	VBN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	Jun/Fos	jun/fos	NN	NN	_	20	compound	_	_
20	heterodimers	heterodimer	NNS	NNS	_	22	nsubj	_	_
21	were	be	VBD	VBD	_	22	cop	_	_
22	able	able	JJ	JJ	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	form	form	VB	VB	_	22	xcomp	_	_
25	an	a	DT	DT	_	27	det	_	_
26	NFAT	nfat	NN	NN	_	27	compound	_	_
27	complex	complex	NN	NN	_	24	dobj	_	_
28	,	,	,	,	_	24	punct	_	_
29	indicating	indicate	VBG	VBG	_	24	advcl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	presence	presence	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	39	case	_	_
33	a	a	DT	DT	_	39	det	_	_
34	constitutively	constitutively	RB	RB	_	35	advmod	_	_
35	expressed	express	VBN	VBN	_	39	amod	_	_
36	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
37	factor	factor	NN	NN	_	39	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	s	s	NNS	NNS	_	31	nmod	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	in	in	IN	IN	_	45	case	_	_
42	B	b	NN	NN	_	45	compound	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	T	t	NN	NN	_	42	conj	_	_
45	cells	cell	NNS	NNS	_	31	nmod	_	_
46	necessary	necessary	JJ	JJ	_	31	amod	_	_
47	for	for	IN	IN	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	formation	formation	NN	NN	_	46	nmod	_	_
50	of	of	IN	IN	_	53	case	_	_
51	the	the	DT	DT	_	53	det	_	_
52	NFAT	nfat	NN	NN	_	53	compound	_	_
53	complex	complex	NN	NN	_	49	nmod	_	_
54	in	in	IN	IN	_	57	case	_	_
55	both	both	DT	DT	_	57	det	_	_
56	cell	cell	NN	NN	_	57	compound	_	_
57	types	type	NNS	NNS	_	46	nmod	_	_
58	.	.	.	.	_	22	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	NFAT	nfat	NN	NN	_	3	compound	_	_
3	oligonucleotide	oligonucleotide	NN	NN	_	15	nsubj	_	_
4	carrying	carry	VBG	VBG	_	3	acl	_	_
5	mutations	mutation	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	5'	5'	JJ	JJ	_	10	amod	_	_
9	purine-rich	purine-rich	JJ	JJ	_	10	amod	_	_
10	part	part	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NFAT	nfat	NN	NN	_	14	compound	_	_
14	sequence	sequence	NN	NN	_	10	nmod	_	_
15	failed	fail	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	form	form	VB	VB	_	15	ccomp	_	_
18	a	a	DT	DT	_	19	det	_	_
19	complex	complex	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	compete	compete	VB	VB	_	17	conj	_	_
23	with	with	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	wild	wild	JJ	JJ	_	27	amod	_	_
26	type	type	NN	NN	_	27	compound	_	_
27	motif	motif	NN	NN	_	22	nmod	_	_
28	for	for	IN	IN	_	31	case	_	_
29	NFAT	nfat	NN	NN	_	31	compound	_	_
30	complex	complex	NN	NN	_	31	compound	_	_
31	formation	formation	NN	NN	_	22	nmod	_	_
32	in	in	IN	IN	_	37	case	_	_
33	both	both	CC	CC	_	34	cc:preconj	_	_
34	T	t	NN	NN	_	37	compound	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	B	b	NN	NN	_	34	conj	_	_
37	cells	cell	NNS	NNS	_	17	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	propose	propose	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	whereby	whereby	WRB	WRB	_	23	advmod	_	_
7	a	a	DT	DT	_	10	det	_	_
8	core	core	NN	NN	_	10	compound	_	_
9	NFAT	nfat	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	23	nsubjpass	_	_
11	consisting	consist	VBG	VBG	_	10	acl	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Jun	jun	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	Fos	fos	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	a	a	DT	DT	_	21	det	_	_
19	constitutive	constitutive	JJ	JJ	_	21	amod	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	factor	factor	NN	NN	_	13	conj	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	formed	form	VBN	VBN	_	5	acl:relcl	_	_
24	in	in	IN	IN	_	29	case	_	_
25	both	both	DT	DT	_	26	cc:preconj	_	_
26	T	t	NN	NN	_	29	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	B	b	NN	NN	_	26	conj	_	_
29	cells	cell	NNS	NNS	_	23	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	but	but	CC	CC	_	23	cc	_	_
32	an	a	DT	DT	_	34	det	_	_
33	additional	additional	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	49	nsubjpass	_	_
35	and/or	and/or	CC	CC	_	34	cc	_	_
36	post-translational	post-translational	JJ	JJ	_	37	amod	_	_
37	modification	modification	NN	NN	_	34	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	a	a	DT	DT	_	40	det	_	_
40	factor	factor	NN	NN	_	37	nmod	_	_
41	,	,	,	,	_	34	punct	_	_
42	missing	miss	VBG	VBG	_	34	amod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	B	b	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	,	,	,	,	_	34	punct	_	_
47	might	might	MD	MD	_	49	aux	_	_
48	be	be	VB	VB	_	49	auxpass	_	_
49	required	require	VBN	VBN	_	23	conj	_	_
50	for	for	IN	IN	_	51	case	_	_
51	transactivation	transactivation	NN	NN	_	49	nmod	_	_
52	by	by	IN	IN	_	53	case	_	_
53	NFAT	nfat	NN	NN	_	51	nmod	_	_
54	.	.	.	.	_	3	punct	_	_

1	1,25-Dihydroxy	1,25-dihydroxy	NN	NN	_	3	compound	_	_
2	vitamin	vitamin	NN	NN	_	3	compound	_	_
3	D3	d3	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	6	compound	_	_
6	phorbol-13-acetate	phorbol-13-acetate	NN	NN	_	3	conj	_	_
7	synergistically	synergistically	RB	RB	_	8	advmod	_	_
8	induce	induce	VBP	VBP	_	0	root	_	_
9	monocytic	monocytic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	differentiation	differentiation	NN	NN	_	8	dobj	_	_
12	:	:	:	:	_	11	punct	_	_
13	FOS	fos	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	RB	rb	NN	NN	_	13	conj	_	_
16	expression	expression	NN	NN	_	11	dep	_	_
17	.	.	.	.	_	8	punct	_	_

1	1,25-dihydroxy	1,25-dihydroxy	NN	NN	_	3	compound	_	_
2	vitamin	vitamin	NN	NN	_	3	compound	_	_
3	D3	d3	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	6	compound	_	_
6	phorbol-13-acetate	phorbol-13-acetate	NN	NN	_	3	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TPA	tpa	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	interact	interact	VBP	VBP	_	0	root	_	_
11	synergistically	synergistically	RB	RB	_	10	advmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	10	xcomp	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	U937	u937	NN	NN	_	20	compound	_	_
18	histiocytic	histiocytic	JJ	JJ	_	20	amod	_	_
19	lymphoma	lymphoma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Addition	addition	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TPA	tpa	NN	NN	_	1	nmod	_	_
4	causes	cause	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	8	det	_	_
6	otherwise	otherwise	JJ	JJ	_	7	amod	_	_
7	ineffective	ineffective	JJ	JJ	_	8	amod	_	_
8	dose	dose	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	1,25-dihydroxy	1,25-dihydroxy	NN	NN	_	12	compound	_	_
11	vitamin	vitamin	NN	NN	_	12	compound	_	_
12	D3	d3	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	induce	induce	VB	VB	_	4	xcomp	_	_
15	differentiation	differentiation	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	induced	induce	VBD	VBD	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
4	depends	depend	VBZ	VBZ	_	0	root	_	_
5	on	on	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	simultaneous	simultaneous	JJ	JJ	_	12	amod	_	_
8	(	(	-LRB-	-LRB-	_	7	punct	_	_
9	vs.	vs.	CC	CC	_	7	cc	_	_
10	sequential	sequential	JJ	JJ	_	7	conj	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	presence	presence	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	both	both	DT	DT	_	15	det	_	_
15	agents	agent	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	induced	induced	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	consistent	consistent	JJ	JJ	_	0	root	_	_
8	with	with	IN	IN	_	13	case	_	_
9	a	a	DT	DT	_	13	det	_	_
10	G1	g1	NN	NN	_	11	nmod:npmod	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	response	response	NN	NN	_	7	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	initiate	initiate	VB	VB	_	13	acl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	metabolic	metabolic	JJ	JJ	_	18	amod	_	_
18	cascade	cascade	NN	NN	_	15	dobj	_	_
19	culminating	culminate	VBG	VBG	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	differentiation	differentiation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	induced	induce	VBD	VBD	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
4	occurs	occur	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	down-regulation	down-regulation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	c-fos	c-fos	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	an	a	DT	DT	_	13	det	_	_
12	accompanying	accompany	VBG	VBG	_	13	amod	_	_
13	up-regulation	up-regulation	NN	NN	_	6	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	RB	rb	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	consistent	consistent	JJ	JJ	_	4	xcomp	_	_
20	with	with	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	possible	possible	JJ	JJ	_	23	amod	_	_
23	need	need	NN	NN	_	19	nmod	_	_
24	for	for	IN	IN	_	29	mark	_	_
25	up-regulated	up-regulated	JJ	JJ	_	27	amod	_	_
26	RB	rb	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	29	nsubj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	maintain	maintain	VB	VB	_	23	acl	_	_
30	a	a	DT	DT	_	33	det	_	_
31	given	given	JJ	JJ	_	33	amod	_	_
32	differentiated	differentiate	VBN	VBN	_	33	amod	_	_
33	phenotype	phenotype	NN	NN	_	29	dobj	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	suppress	suppress	VB	VB	_	29	conj	_	_
36	transcriptional	transcriptional	JJ	JJ	_	37	amod	_	_
37	activators	activator	NNS	NNS	_	35	dobj	_	_
38	that	that	WDT	WDT	_	42	nsubjpass	_	_
39	might	might	MD	MD	_	42	aux	_	_
40	typically	typically	RB	RB	_	42	advmod	_	_
41	be	be	VB	VB	_	42	auxpass	_	_
42	associated	associate	VBN	VBN	_	37	acl:relcl	_	_
43	with	with	IN	IN	_	44	case	_	_
44	proliferation	proliferation	NN	NN	_	42	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	lymphoid-specific	lymphoid-specific	JJ	JJ	_	9	amod	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
5	mu	mu	NN	NN	_	9	compound	_	_
6	heavy	heavy	NN	NN	_	9	compound	_	_
7	chain	chain	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	enhancer	enhancer	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	ETS-domain	ets-domain	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	enhancer	enhancer	NN	NN	_	13	nsubj	_	_
3	for	for	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	immunoglobulin	immunoglobulin	NN	NN	_	9	compound	_	_
6	mu	mu	NN	NN	_	9	compound	_	_
7	heavy	heavy	NN	NN	_	9	compound	_	_
8	chain	chain	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	2	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IgH	igh	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	activates	activate	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	heterologous	heterologous	JJ	JJ	_	16	amod	_	_
16	gene	gene	NN	NN	_	13	dobj	_	_
17	at	at	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	pre-B	pre-b	JJ	JJ	_	20	dep	_	_
20	cell	cell	NN	NN	_	21	amod	_	_
21	stage	stage	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	lymphocyte	lymphocyte	NN	NN	_	25	compound	_	_
25	differentiation	differentiation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	lymphoid-specific	lymphoid-specific	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	8	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	microB	microb	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	necessary	necessary	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	pre-B	pre-b	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	microB	microb	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	encoded	encode	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	PU.1/Spi-1	pu.1/spi-1	NN	NN	_	10	compound	_	_
10	proto-oncogene	proto-oncogene	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Another	another	DT	DT	_	3	det	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	8	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	microA	microa	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	mu	mu	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	product	product	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	ets-1	ets-1	NN	NN	_	20	compound	_	_
20	proto-oncogene	proto-oncogene	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	microA	microa	NN	NN	_	3	compound	_	_
3	motif	motif	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	aux	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	microB-dependent	microb-dependent	JJ	JJ	_	9	amod	_	_
8	enhancer	enhancer	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	suggests	suggest	VBZ	VBZ	_	5	ccomp	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	a	a	DT	DT	_	18	det	_	_
15	minimal	minimal	JJ	JJ	_	18	amod	_	_
16	B	b	NN	NN	_	17	nmod:npmod	_	_
17	cell-specific	cell-specific	JJ	JJ	_	18	amod	_	_
18	enhancer	enhancer	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	composed	compose	VBN	VBN	_	12	ccomp	_	_
21	of	of	IN	IN	_	28	case	_	_
22	both	both	CC	CC	_	28	cc:preconj	_	_
23	the	the	DT	DT	_	28	det	_	_
24	PU.1	pu.1	NN	NN	_	28	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Ets-1	ets-1	NN	NN	_	24	conj	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Co-expression	co-expression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	PU.1	pu.1	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Ets-1	ets-1	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	nonlymphoid	nonlymphoid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	trans-activated	trans-activated	JJ	JJ	_	0	root	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	plasmids	plasmid	NNS	NNS	_	10	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	contained	contain	VBD	VBD	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	minimal	minimal	JJ	JJ	_	18	amod	_	_
17	mu	mu	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	members	member	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Ets	ets	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	IgH	igh	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	autoregulation	autoregulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	T-	t-	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	B-cell	b-cell	NN	NN	_	9	conj	_	_
12	lines	line	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	8	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GR	gr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	cognate	cognate	JJ	JJ	_	12	amod	_	_
12	ligand	ligand	NN	NN	_	1	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	examined	examine	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	glucocorticoid-sensitive	glucocorticoid-sensitive	JJ	JJ	_	22	amod	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	leukemic	leukemic	JJ	JJ	_	22	amod	_	_
20	T-cell	t-cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	6TG1.1	6tg1.1	NN	NN	_	14	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	in	in	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	B-cell	b-cell	NN	NN	_	29	compound	_	_
28	line	line	NN	NN	_	29	compound	_	_
29	IM-9	im-9	NN	NN	_	22	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	decrease	decrease	NN	NN	_	27	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	GR	gr	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	seen	see	VBN	VBN	_	5	acl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	IM-9	im-9	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	treatment	treatment	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	1	1	CD	CD	_	17	compound	_	_
17	microM	microm	NN	NN	_	18	amod	_	_
18	dexamethasone	dexamethasone	NN	NN	_	14	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	16-18	16-18	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	14	nmod	_	_
22	,	,	,	,	_	27	punct	_	_
23	treatment	treatment	NN	NN	_	27	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	6TG1.1	6tg1.1	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	resulted	result	VBD	VBD	_	0	root	_	_
28	in	in	IN	IN	_	31	case	_	_
29	an	a	DT	DT	_	31	det	_	_
30	8-fold	8-fold	JJ	JJ	_	31	amod	_	_
31	increase	increase	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	GR	gr	NN	NN	_	34	compound	_	_
34	mRNA	mrna	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	27	punct	_	_
36	as	as	IN	IN	_	37	mark	_	_
37	determined	determine	VBN	VBN	_	27	advcl	_	_
38	by	by	IN	IN	_	44	case	_	_
39	Northern	northern	NN	NN	_	40	compound	_	_
40	blot	blot	NN	NN	_	44	compound	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	RNase	rnase	NN	NN	_	43	compound	_	_
43	protection	protection	NN	NN	_	40	conj	_	_
44	analysis	analysis	NN	NN	_	37	nmod	_	_
45	,	,	,	,	_	27	punct	_	_
46	with	with	IN	IN	_	52	case	_	_
47	a	a	DT	DT	_	52	det	_	_
48	corresponding	corresponding	JJ	JJ	_	52	amod	_	_
49	3-	3-	CD	CD	_	52	amod	_	_
50	to	to	TO	TO	_	49	dep	_	_
51	4-fold	4-fold	JJ	JJ	_	49	dep	_	_
52	increase	increase	NN	NN	_	27	nmod	_	_
53	in	in	IN	IN	_	55	case	_	_
54	GR	gr	NN	NN	_	55	compound	_	_
55	protein	protein	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	27	punct	_	_

1	Half-maximal	half-maximal	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GR	gr	NN	NN	_	2	nmod	_	_
5	mRNA	mrna	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	protein	protein	NN	NN	_	5	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	6TG1.1	6tg1.1	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	between	between	IN	IN	_	16	case	_	_
14	10-100	10-100	CD	CD	_	15	dep	_	_
15	nM	nm	NN	NN	_	16	dep	_	_
16	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	inclusion	inclusion	NN	NN	_	26	nsubj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	1	1	CD	CD	_	22	compound	_	_
22	microM	microm	NN	NN	_	23	amod	_	_
23	RU	ru	NN	NN	_	19	nmod	_	_
24	38486	38486	CD	CD	_	23	nummod	_	_
25	completely	completely	RB	RB	_	26	advmod	_	_
26	blocked	block	VBD	VBD	_	12	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	effects	effect	NNS	NNS	_	26	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	100	100	CD	CD	_	31	compound	_	_
31	nM	nm	NN	NN	_	32	amod	_	_
32	dexamethasone	dexamethasone	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	26	punct	_	_
34	demonstrating	demonstrate	VBG	VBG	_	26	advcl	_	_
35	that	that	IN	IN	_	47	mark	_	_
36	positive	positive	JJ	JJ	_	37	amod	_	_
37	autoregulation	autoregulation	NN	NN	_	47	nsubj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	GR	gr	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	37	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	6TG1.1	6tg1.1	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	37	nmod	_	_
44	is	be	VBZ	VBZ	_	47	cop	_	_
45	a	a	DT	DT	_	47	det	_	_
46	receptor-mediated	receptor-mediated	JJ	JJ	_	47	amod	_	_
47	response	response	NN	NN	_	34	ccomp	_	_
48	.	.	.	.	_	12	punct	_	_

1	Positive	positive	JJ	JJ	_	2	amod	_	_
2	autoregulation	autoregulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	glucocorticoid-resistant	glucocorticoid-resistant	JJ	JJ	_	12	amod	_	_
11	CEM-C1	cem-c1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	contain	contain	VBP	VBP	_	12	acl:relcl	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	GR	gr	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	15	punct	_	_
19	but	but	CC	CC	_	15	cc	_	_
20	whose	whose	WP$	WP$	_	21	nmod:poss	_	_
21	growth	growth	NN	NN	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	unaffected	unaffect	VBN	VBN	_	15	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	glucocorticoids	glucocorticoid	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	positive	positive	JJ	JJ	_	4	amod	_	_
4	autoregulation	autoregulation	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	neither	neither	CC	CC	_	8	cc:preconj	_	_
7	a	a	DT	DT	_	8	det	_	_
8	consequence	consequence	NN	NN	_	0	root	_	_
9	nor	nor	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	sole	sole	JJ	JJ	_	12	amod	_	_
12	cause	cause	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	arrest	arrest	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	degree	degree	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	autoregulation	autoregulation	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	IM-9	im-9	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	positive	positive	JJ	JJ	_	11	amod	_	_
11	autoregulation	autoregulation	NN	NN	_	5	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	6TG1.1	6tg1.1	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	unaffected	unaffect	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	inhibition	inhibition	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	synthesis	synthesis	NN	NN	_	18	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	cycloheximide	cycloheximide	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	16	punct	_	_

1	Measurement	measurement	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	GR	gr	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	turnover	turnover	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	6TG1.1	6tg1.1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	treated	treat	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	actinomycin-D	actinomycin-d	NN	NN	_	9	nmod	_	_
12	revealed	reveal	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	half-life	half-life	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	2.5	2.5	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	was	be	VBD	VBD	_	21	aux	_	_
21	unaffected	unaffected	JJ	JJ	_	14	acl:relcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	dexamethasone	dexamethasone	NN	NN	_	24	compound	_	_
24	treatment	treatment	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	half-life	half-life	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	determined	determine	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	IM-9	im-9	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	was	be	VBD	VBD	_	12	aux	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	unaffected	unaffected	JJ	JJ	_	5	conj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	steroid	steroid	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	interpretation	interpretation	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	10	amod	_	_
10	autoregulation	autoregulation	NN	NN	_	19	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	GR	gr	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	19	cop	_	_
15	a	a	DT	DT	_	19	det	_	_
16	tissue-specific	tissue-specific	JJ	JJ	_	19	amod	_	_
17	primary	primary	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	7	ccomp	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	p65	p65	NN	NN	_	3	compound	_	_
3	subunit	subunit	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	regulates	regulate	VBZ	VBZ	_	0	root	_	_
8	I	i	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	dobj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	Transcription	transcription	NN	NN	_	4	compound	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	10	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	p50/p65	p50/p65	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	10	aux	_	_
9	generally	generally	RB	RB	_	10	advmod	_	_
10	localized	localized	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	19	case	_	_
15	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
16	inhibitor	inhibitor	NN	NN	_	19	compound	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Overproduced	overproduced	JJ	JJ	_	4	amod	_	_
2	I	i	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	13	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	free	free	JJ	JJ	_	4	amod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	degraded	degrade	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	p65	p65	NN	NN	_	1	nmod	_	_
4	increases	increase	VBZ	VBZ	_	0	root	_	_
5	endogenous	endogenous	JJ	JJ	_	9	amod	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	carcinoma	carcinoma	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	lymphoid	lymphoid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	by	by	IN	IN	_	18	case	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
19	:	:	:	:	_	18	punct	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	stabilization	stabilization	NN	NN	_	18	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	increased	increase	VBN	VBN	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	I	i	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	mRNA	mrna	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	p65	p65	NN	NN	_	5	compound	_	_
5	delta	delta	NN	NN	_	13	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	11	det	_	_
8	naturally	naturally	RB	RB	_	9	advmod	_	_
9	occurring	occur	VBG	VBG	_	11	amod	_	_
10	splice	splice	NN	NN	_	11	compound	_	_
11	variant	variant	NN	NN	_	5	appos	_	_
12	,	,	,	,	_	5	punct	_	_
13	fails	fail	VBZ	VBZ	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	markedly	markedly	RB	RB	_	16	advmod	_	_
16	augment	augment	VB	VB	_	13	xcomp	_	_
17	I	i	NN	NN	_	21	compound	_	_
18	kappa	kappa	NN	NN	_	21	compound	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	16	dobj	_	_
22	.	.	.	.	_	13	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	overexpressed	overexpressed	JJ	JJ	_	3	amod	_	_
3	p65	p65	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	coexpressed	coexpressed	JJ	JJ	_	6	amod	_	_
6	p50	p50	NN	NN	_	3	conj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	whereas	whereas	IN	IN	_	8	dep	_	_
11	p65	p65	NN	NN	_	12	compound	_	_
12	delta	delta	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	partly	partly	RB	RB	_	15	advmod	_	_
15	nuclear	nuclear	JJ	JJ	_	8	parataxis	_	_
16	,	,	,	,	_	8	punct	_	_
17	indicating	indicate	VBG	VBG	_	8	parataxis	_	_
18	that	that	IN	IN	_	27	mark	_	_
19	the	the	DT	DT	_	22	det	_	_
20	I	i	NN	NN	_	22	compound	_	_
21	kappa	kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	27	nsubj	_	_
23	induced	induce	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	p65	p65	NN	NN	_	23	nmod	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	maintain	maintain	VB	VB	_	17	ccomp	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	cytoplasm	cytoplasm	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	p65	p65	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	I	i	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	3	conj	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	linked	link	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	autoregulatory	autoregulatory	JJ	JJ	_	13	amod	_	_
13	loop	loop	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	ensuring	ensure	VBG	VBG	_	9	xcomp	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	held	hold	VBN	VBN	_	15	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	cytoplasm	cytoplasm	NN	NN	_	20	nmod	_	_
24	until	until	IN	IN	_	28	mark	_	_
25	cells	cell	NNS	NNS	_	28	nsubjpass	_	_
26	are	be	VBP	VBP	_	28	auxpass	_	_
27	specifically	specifically	RB	RB	_	28	advmod	_	_
28	induced	induce	VBN	VBN	_	20	advcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	translocate	translocate	VB	VB	_	28	xcomp	_	_
31	it	it	PRP	PRP	_	30	dobj	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	cycle	cycle	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	E2F	e2f	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	primary	primary	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	reveals	reveal	VBZ	VBZ	_	0	root	_	_
12	novel	novel	JJ	JJ	_	14	amod	_	_
13	E2F	e2f	NN	NN	_	14	compound	_	_
14	complexes	complex	NNS	NNS	_	11	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	biochemically	biochemically	RB	RB	_	17	advmod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	forms	form	NNS	NNS	_	14	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	free	free	JJ	JJ	_	21	amod	_	_
21	E2F	e2f	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	E2F	e2f	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	multiple	multiple	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	involved	involve	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	proliferation	proliferation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	c-myc	c-myc	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	dihydrofolate	dihydrofolate	JJ	JJ	_	23	amod	_	_
22	reductase	reductase	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Regulation	regulation	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	E2F	e2f	NN	NN	_	1	nmod	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	its	its	PRP$	PRP$	_	6	nmod:poss	_	_
6	interactions	interaction	NNS	NNS	_	4	dobj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	other	other	JJ	JJ	_	10	amod	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	including	include	VBG	VBG	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	retinoblastoma	retinoblastoma	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Rb	rb	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	the	the	DT	DT	_	23	det	_	_
21	Rb-related	rb-related	JJ	JJ	_	23	amod	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	p107	p107	NN	NN	_	15	conj	_	_
24	,	,	,	,	_	15	punct	_	_
25	cyclin	cyclin	NN	NN	_	26	compound	_	_
26	A	a	NN	NN	_	15	conj	_	_
27	,	,	,	,	_	15	punct	_	_
28	and	and	CC	CC	_	15	cc	_	_
29	cdk2	cdk2	NN	NN	_	15	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	undertook	undertake	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	detailed	detailed	JJ	JJ	_	5	amod	_	_
5	analysis	analysis	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	E2F	e2f	NN	NN	_	9	compound	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	activities	activity	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	cycle	cycle	NN	NN	_	14	compound	_	_
14	behavior	behavior	NN	NN	_	9	conj	_	_
15	in	in	IN	IN	_	19	case	_	_
16	primary	primary	JJ	JJ	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Three	three	CD	CD	_	4	nummod	_	_
2	E2F	e2f	NN	NN	_	4	compound	_	_
3	DNA-binding	dna-binding	JJ	JJ	_	4	amod	_	_
4	activities	activity	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	13	case	_	_
8	resting	rest	VBG	VBG	_	13	amod	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	G0	g0	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	mobilities	mobility	NNS	NNS	_	6	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	gel	gel	NN	NN	_	19	compound	_	_
18	shift	shift	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	20	nmod	_	_
20	distinct	distinct	JJ	JJ	_	15	amod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	those	those	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	previously	previously	RB	RB	_	25	advmod	_	_
25	defined	define	VBN	VBN	_	27	amod	_	_
26	E2F	e2f	NN	NN	_	27	compound	_	_
27	complexes	complex	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	activities	activity	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	16	mark	_	_
8	be	be	VB	VB	_	16	cop	_	_
9	a	a	DT	DT	_	16	det	_	_
10	novel	novel	JJ	JJ	_	16	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	less	less	RBR	RBR	_	13	advmod	_	_
13	abundant	abundant	JJ	JJ	_	10	dep	_	_
14	,	,	,	,	_	10	punct	_	_
15	Rb-E2F	rb-e2f	NN	NN	_	10	dep	_	_
16	complex	complex	NN	NN	_	6	xcomp	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	most	most	RBS	RBS	_	3	advmod	_	_
3	prominent	prominent	JJ	JJ	_	5	amod	_	_
4	E2F	e2f	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	16	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	resting	rest	VBG	VBG	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	5	punct	_	_
11	termed	term	VBN	VBN	_	5	acl	_	_
12	complex	complex	JJ	JJ	_	13	amod	_	_
13	X	x	NN	NN	_	11	xcomp	_	_
14	)	)	-RRB-	-RRB-	_	5	punct	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	abundant	abundant	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	G0	g0	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	G1	g1	NN	NN	_	19	conj	_	_
22	but	but	CC	CC	_	16	cc	_	_
23	disappeared	disappear	VBD	VBD	_	16	conj	_	_
24	as	as	IN	IN	_	26	mark	_	_
25	cells	cell	NNS	NNS	_	26	nsubj	_	_
26	entered	enter	VBD	VBD	_	23	advcl	_	_
27	S	s	NN	NN	_	28	compound	_	_
28	phase	phase	NN	NN	_	26	dobj	_	_
29	,	,	,	,	_	16	punct	_	_
30	suggesting	suggest	VBG	VBG	_	16	advcl	_	_
31	a	a	DT	DT	_	33	det	_	_
32	possible	possible	JJ	JJ	_	33	amod	_	_
33	role	role	NN	NN	_	30	dobj	_	_
34	in	in	IN	IN	_	38	case	_	_
35	negatively	negatively	RB	RB	_	36	advmod	_	_
36	regulating	regulate	VBG	VBG	_	38	amod	_	_
37	E2F	e2f	NN	NN	_	38	compound	_	_
38	function	function	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	16	punct	_	_

1	Complex	complex	NN	NN	_	2	compound	_	_
2	X	x	NN	NN	_	5	nsubjpass	_	_
3	could	could	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	dissociated	dissociate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	adenovirus	adenovirus	NN	NN	_	8	compound	_	_
8	E1A	e1a	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	requirement	requirement	NN	NN	_	5	nmod	_	_
12	for	for	IN	IN	_	17	case	_	_
13	an	a	DT	DT	_	17	det	_	_
14	intact	intact	JJ	JJ	_	17	amod	_	_
15	E1A	e1a	NN	NN	_	17	compound	_	_
16	conserved	conserve	VBN	VBN	_	17	amod	_	_
17	region	region	NN	NN	_	11	nmod	_	_
18	2	2	CD	CD	_	17	nummod	_	_
19	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	X	x	NN	NN	_	4	nsubj	_	_
4	failed	fail	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	react	react	VB	VB	_	4	xcomp	_	_
7	with	with	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	variety	variety	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	antibodies	antibody	NNS	NNS	_	9	nmod	_	_
12	against	against	IN	IN	_	13	case	_	_
13	Rb	rb	NN	NN	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	p107	p107	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	implicating	implicate	VBG	VBG	_	4	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	involvement	involvement	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	E1A-binding	e1a-binding	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	19	nmod	_	_
24	other	other	JJ	JJ	_	26	case	_	_
25	than	than	IN	IN	_	26	case	_	_
26	Rb	rb	NN	NN	_	23	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	p107	p107	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	addition	addition	NN	NN	_	7	dep	_	_
3	to	to	TO	TO	_	7	case	_	_
4	these	these	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	E2F	e2f	NN	NN	_	7	compound	_	_
7	complexes	complex	NNS	NNS	_	19	nmod	_	_
8	,	,	,	,	_	19	punct	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	forms	form	NNS	NNS	_	19	nsubjpass	_	_
12	of	of	IN	IN	_	17	case	_	_
13	unbound	unbound	JJ	JJ	_	17	amod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	free	free	JJ	JJ	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	E2F	e2f	NN	NN	_	11	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	resolved	resolve	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	gel	gel	NN	NN	_	23	compound	_	_
22	shift	shift	NN	NN	_	23	compound	_	_
23	experiments	experiment	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	species	species	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	cycle	cycle	NN	NN	_	7	compound	_	_
7	kinetics	kinetics	NNS	NNS	_	3	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	UV	uv	NN	NN	_	3	compound	_	_
2	cross-linking	cross-linking	JJ	JJ	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	suggested	suggest	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	a	a	DT	DT	_	10	det	_	_
7	distinct	distinct	JJ	JJ	_	10	amod	_	_
8	E2F	e2f	NN	NN	_	10	compound	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	uniquely	uniquely	RB	RB	_	13	advmod	_	_
13	associated	associate	VBN	VBN	_	4	ccomp	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	S-phase	s-phase	NN	NN	_	18	compound	_	_
17	p107	p107	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	associated	associate	VBN	VBN	_	13	conj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	Rb	rb	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	E2F	e2f	NN	NN	_	8	nsubj	_	_
8	consists	consist	VBZ	VBZ	_	5	ccomp	_	_
9	of	of	IN	IN	_	15	case	_	_
10	multiple	multiple	JJ	JJ	_	15	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	biochemically	biochemically	RB	RB	_	13	advmod	_	_
13	distinct	distinct	JJ	JJ	_	10	dep	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	8	nmod	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	function	function	VBP	VBP	_	15	acl:relcl	_	_
18	at	at	IN	IN	_	20	case	_	_
19	different	different	JJ	JJ	_	20	amod	_	_
20	points	point	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	cycle	cycle	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Occurrence	occurrence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	silencer	silencer	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	interleukin-2	interleukin-2	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	naive	naive	JJ	JJ	_	18	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	in	in	IN	IN	_	14	case	_	_
14	memory	memory	NN	NN	_	10	conj	_	_
15	resting	rest	VBG	VBG	_	14	amod	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	helper	helper	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	system	system	NN	NN	_	18	nmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	18	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	naive	naive	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	7	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	antigen	antigen	NN	NN	_	7	nmod	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	a	a	DT	DT	_	18	det	_	_
17	key	key	JJ	JJ	_	18	amod	_	_
18	step	step	NN	NN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	shaping	shaping	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
25	T	t	NN	NN	_	28	compound	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	specificity	specificity	NN	NN	_	28	compound	_	_
28	repertoire	repertoire	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	21	cc	_	_
30	maintenance	maintenance	NN	NN	_	21	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	self-tolerance	self-tolerance	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	analysis	analysis	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	interleukin-2	interleukin-2	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-2	il-2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	6	nmod	_	_
15	shows	show	VBZ	VBZ	_	0	root	_	_
16	that	that	IN	IN	_	34	mark	_	_
17	naive	naive	JJ	JJ	_	21	amod	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	helper	helper	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	34	nsubj	_	_
22	(	(	-LRB-	-LRB-	_	27	punct	_	_
23	cord	cord	NN	NN	_	27	compound	_	_
24	blood	blood	NN	NN	_	27	compound	_	_
25	CD4+	cd4+	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	21	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	adult	adult	JJ	JJ	_	32	amod	_	_
30	CD4+CD45RO-	cd4+cd45ro-	JJ	JJ	_	32	amod	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	appos	_	_
33	)	)	-RRB-	-RRB-	_	27	punct	_	_
34	regulate	regulate	VBP	VBP	_	15	ccomp	_	_
35	IL-2	il-2	NN	NN	_	36	compound	_	_
36	transcription	transcription	NN	NN	_	34	dobj	_	_
37	by	by	IN	IN	_	39	case	_	_
38	a	a	DT	DT	_	39	det	_	_
39	mechanism	mechanism	NN	NN	_	34	nmod	_	_
40	involving	involve	VBG	VBG	_	39	acl	_	_
41	both	both	CC	CC	_	43	cc:preconj	_	_
42	a	a	DT	DT	_	43	det	_	_
43	silencer	silencer	NN	NN	_	40	dobj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	an	a	DT	DT	_	46	det	_	_
46	activator	activator	NN	NN	_	43	conj	_	_
47	acting	act	VBG	VBG	_	43	acl	_	_
48	on	on	IN	IN	_	53	case	_	_
49	the	the	DT	DT	_	53	det	_	_
50	purine-rich	purine-rich	JJ	JJ	_	53	amod	_	_
51	IL-2	il-2	NN	NN	_	53	compound	_	_
52	promoter	promoter	NN	NN	_	53	compound	_	_
53	elements	element	NNS	NNS	_	47	nmod	_	_
54	(	(	-LRB-	-LRB-	_	57	punct	_	_
55	NF-AT	nf-at	NN	NN	_	57	compound	_	_
56	binding	binding	NN	NN	_	57	compound	_	_
57	sites	site	NNS	NNS	_	53	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	15	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	38	nmod	_	_
3	,	,	,	,	_	38	punct	_	_
4	memory	memory	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	38	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	either	either	CC	CC	_	13	cc:preconj	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	10	advmod	_	_
10	activated	activate	VBN	VBN	_	13	amod	_	_
11	helper	helper	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	5	appos	_	_
14	reverting	revert	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	resting	resting	JJ	JJ	_	18	amod	_	_
18	state	state	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	or	or	CC	CC	_	13	cc	_	_
21	CD4+	cd4+	JJ	JJ	_	26	amod	_	_
22	T	t	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	memory	memory	NN	NN	_	26	compound	_	_
25	)	)	-RRB-	-RRB-	_	26	punct	_	_
26	clones	clone	NNS	NNS	_	13	conj	_	_
27	,	,	,	,	_	13	punct	_	_
28	or	or	CC	CC	_	13	cc	_	_
29	CD4+CD45RO+	cd4+cd45ro+	JJ	JJ	_	31	amod	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	13	conj	_	_
32	isolated	isolate	VBN	VBN	_	31	acl	_	_
33	ex	ex	FW	FW	_	34	compound	_	_
34	vivo	vivo	FW	FW	_	32	advmod	_	_
35	,	,	,	,	_	5	punct	_	_
36	no	no	RB	RB	_	37	neg	_	_
37	longer	longer	RB	RB	_	38	advmod	_	_
38	have	have	VBP	VBP	_	0	root	_	_
39	a	a	DT	DT	_	40	det	_	_
40	silencer	silencer	NN	NN	_	38	dobj	_	_
41	.	.	.	.	_	38	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	4	nsubj	_	_
4	seems	seem	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	controlled	control	VBN	VBN	_	4	xcomp	_	_
8	solely	solely	RB	RB	_	11	advmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	transition	transition	NN	NN	_	7	nmod	_	_
12	from	from	IN	IN	_	13	case	_	_
13	inactive	inactive	JJ	JJ	_	17	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	active	active	JJ	JJ	_	17	nmod	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	state	state	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	positive	positive	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	17	nmod	_	_
23	binding	bind	VBG	VBG	_	22	acl	_	_
24	to	to	TO	TO	_	27	case	_	_
25	these	these	DT	DT	_	27	det	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	elements	element	NNS	NNS	_	23	nmod	_	_
28	as	as	RB	RB	_	27	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
32	cytoplasmic	cytoplasmic	JJ	JJ	_	35	amod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	nuclear	nuclear	JJ	JJ	_	32	conj	_	_
35	location	location	NN	NN	_	27	conj	_	_
36	:	:	:	:	_	4	punct	_	_
37	in	in	IN	IN	_	41	case	_	_
38	resting	rest	VBG	VBG	_	41	amod	_	_
39	memory	memory	NN	NN	_	41	compound	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	45	nmod	_	_
42	the	the	DT	DT	_	43	det	_	_
43	activator	activator	NN	NN	_	45	nsubj	_	_
44	is	be	VBZ	VBZ	_	45	cop	_	_
45	located	located	JJ	JJ	_	4	parataxis	_	_
46	in	in	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	cytoplasm	cytoplasm	NN	NN	_	45	nmod	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	is	be	VBZ	VBZ	_	51	cop	_	_
51	inactive	inactive	JJ	JJ	_	45	conj	_	_
52	,	,	,	,	_	45	punct	_	_
53	whereas	whereas	IN	IN	_	45	dep	_	_
54	in	in	IN	IN	_	56	case	_	_
55	stimulated	stimulate	VBN	VBN	_	56	amod	_	_
56	cells	cell	NNS	NNS	_	59	nmod	_	_
57	it	it	PRP	PRP	_	59	nsubj	_	_
58	is	be	VBZ	VBZ	_	59	cop	_	_
59	functional	functional	JJ	JJ	_	45	parataxis	_	_
60	in	in	IN	IN	_	61	mark	_	_
61	promoting	promote	VBG	VBG	_	59	advcl	_	_
62	transcription	transcription	NN	NN	_	61	dobj	_	_
63	and	and	CC	CC	_	59	cc	_	_
64	now	now	RB	RB	_	65	advmod	_	_
65	resides	reside	VBZ	VBZ	_	59	conj	_	_
66	in	in	IN	IN	_	68	case	_	_
67	the	the	DT	DT	_	68	det	_	_
68	nucleus	nucleus	NN	NN	_	65	nmod	_	_
69	.	.	.	.	_	45	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	gene	gene	NN	NN	_	4	nmod	_	_
8	coding	code	VBG	VBG	_	7	amod	_	_
9	for	for	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	main	main	JJ	JJ	_	15	amod	_	_
12	T	t	NN	NN	_	15	compound	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	7	nmod	_	_
16	changes	change	VBZ	VBZ	_	0	root	_	_
17	irreversibly	irreversibly	RB	RB	_	16	advmod	_	_
18	after	after	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	first	first	JJ	JJ	_	21	amod	_	_
21	encounter	encounter	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	antigen	antigen	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	likely	likely	JJ	JJ	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	silencer	silencer	NN	NN	_	7	nmod	_	_
11	contributes	contribute	VBZ	VBZ	_	4	ccomp	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	stringent	stringent	JJ	JJ	_	17	amod	_	_
16	activation	activation	NN	NN	_	17	compound	_	_
17	requirements	requirement	NNS	NNS	_	11	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	naive	naive	JJ	JJ	_	22	amod	_	_
20	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Single	single	JJ	JJ	_	5	amod	_	_
2	strand	strand	NN	NN	_	5	compound	_	_
3	conformation	conformation	NN	NN	_	5	compound	_	_
4	polymorphism	polymorphism	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	androgen	androgen	NN	NN	_	10	compound	_	_
8	receptor	receptor	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	mutations	mutation	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	androgen	androgen	NN	NN	_	16	compound	_	_
15	insensitivity	insensitivity	NN	NN	_	16	compound	_	_
16	syndromes	syndrome	NNS	NNS	_	12	nmod	_	_
17	:	:	:	:	_	5	punct	_	_
18	application	application	NN	NN	_	5	dep	_	_
19	for	for	IN	IN	_	20	case	_	_
20	diagnosis	diagnosis	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	genetic	genetic	JJ	JJ	_	23	amod	_	_
23	counseling	counseling	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	therapy	therapy	NN	NN	_	20	conj	_	_
27	.	.	.	.	_	18	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	mutations	mutation	NNS	NNS	_	12	nsubjpass	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	androgen	androgen	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	3	ccomp	_	_
13	with	with	IN	IN	_	16	case	_	_
14	androgen	androgen	NN	NN	_	16	compound	_	_
15	insensitivity	insensitivity	NN	NN	_	16	compound	_	_
16	syndromes	syndrome	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	heterogeneous	heterogeneous	JJ	JJ	_	20	amod	_	_
20	group	group	NN	NN	_	16	appos	_	_
21	of	of	IN	IN	_	23	case	_	_
22	related	related	JJ	JJ	_	23	amod	_	_
23	disorders	disorder	NNS	NNS	_	20	nmod	_	_
24	involving	involve	VBG	VBG	_	23	acl	_	_
25	defective	defective	JJ	JJ	_	27	amod	_	_
26	sexual	sexual	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	karyotypic	karyotypic	JJ	JJ	_	30	amod	_	_
30	males	male	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	address	address	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	possibility	possibility	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	rapid	rapid	JJ	JJ	_	12	amod	_	_
11	mutational	mutational	JJ	JJ	_	12	amod	_	_
12	analysis	analysis	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	androgen	androgen	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	12	nmod	_	_
18	for	for	IN	IN	_	20	case	_	_
19	initial	initial	JJ	JJ	_	20	amod	_	_
20	diagnosis	diagnosis	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	genetic	genetic	JJ	JJ	_	23	amod	_	_
23	counseling	counseling	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	molecular	molecular	JJ	JJ	_	27	amod	_	_
27	subclassification	subclassification	NN	NN	_	20	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	affected	affect	VBN	VBN	_	30	amod	_	_
30	patients	patient	NNS	NNS	_	20	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	their	they	PRP$	PRP$	_	33	nmod:poss	_	_
33	families	family	NNS	NNS	_	30	conj	_	_
34	.	.	.	.	_	6	punct	_	_

1	DNA	dna	NN	NN	_	19	nsubjpass	_	_
2	from	from	IN	IN	_	5	case	_	_
3	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	leukocytes	leukocyte	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	six	six	CD	CD	_	8	nummod	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	five	five	CD	CD	_	11	nummod	_	_
11	families	family	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	various	various	JJ	JJ	_	14	amod	_	_
14	degrees	degree	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	androgen	androgen	NN	NN	_	17	compound	_	_
17	insensitivity	insensitivity	NN	NN	_	14	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	studied	study	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Exons	exon	NNS	NNS	_	11	nsubjpass	_	_
2	2	2	CD	CD	_	1	dep	_	_
3	to	to	TO	TO	_	2	dep	_	_
4	8	8	CD	CD	_	2	dep	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	androgen	androgen	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	1	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	using	use	VBG	VBG	_	11	xcomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	combination	combination	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	single	single	JJ	JJ	_	20	amod	_	_
17	strand	strand	NN	NN	_	20	compound	_	_
18	conformation	conformation	NN	NN	_	20	compound	_	_
19	polymorphism	polymorphism	NN	NN	_	20	compound	_	_
20	analysis	analysis	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	direct	direct	JJ	JJ	_	24	amod	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	sequencing	sequencing	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	Female	female	JJ	JJ	_	3	amod	_	_
2	family	family	NN	NN	_	3	compound	_	_
3	members	member	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	studied	study	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	xcomp	_	_
9	heterozygote	heterozygote	NN	NN	_	10	compound	_	_
10	carriers	carrier	NNS	NNS	_	8	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	Point	point	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	AR	ar	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	all	all	DT	DT	_	11	advmod	_	_
11	six	six	CD	CD	_	12	nummod	_	_
12	patients	patient	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	all	all	DT	DT	_	16	det	_	_
16	mutations	mutation	NNS	NNS	_	17	nsubj	_	_
17	caused	cause	VBD	VBD	_	8	conj	_	_
18	amino	amino	NN	NN	_	20	compound	_	_
19	acid	acid	NN	NN	_	20	compound	_	_
20	substitutions	substitution	NNS	NNS	_	17	dobj	_	_
21	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	patient	patient	NN	NN	_	9	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	incomplete	incomplete	JJ	JJ	_	6	amod	_	_
5	androgen	androgen	NN	NN	_	6	compound	_	_
6	insensitivity	insensitivity	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	mosaic	mosaic	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mutation	mutation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Four	four	CD	CD	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	five	five	CD	CD	_	5	nummod	_	_
5	mothers	mother	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	as	as	RB	RB	_	1	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	a	a	DT	DT	_	12	det	_	_
11	young	young	JJ	JJ	_	12	amod	_	_
12	sister	sister	NN	NN	_	1	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	one	one	CD	CD	_	15	nummod	_	_
15	patient	patient	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	1	punct	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	carriers	carrier	NNS	NNS	_	0	root	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	mutation	mutation	NN	NN	_	18	nmod	_	_
22	present	present	JJ	JJ	_	21	amod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	affected	affect	VBN	VBN	_	26	amod	_	_
26	child	child	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	mutations	mutation	NNS	NNS	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	occur	occur	VB	VB	_	3	ccomp	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	androgen	androgen	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	leading	lead	VBG	VBG	_	8	xcomp	_	_
15	to	to	TO	TO	_	19	case	_	_
16	sporadic	sporadic	JJ	JJ	_	19	amod	_	_
17	androgen	androgen	NN	NN	_	19	compound	_	_
18	insensitivity	insensitivity	NN	NN	_	19	compound	_	_
19	syndrome	syndrome	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Molecular	molecular	JJ	JJ	_	3	amod	_	_
2	genetic	genetic	JJ	JJ	_	3	amod	_	_
3	characterization	characterization	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	variant	variant	JJ	JJ	_	7	amod	_	_
7	allele	allele	NN	NN	_	3	nmod	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	serve	serve	VB	VB	_	0	root	_	_
10	as	as	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	primary	primary	JJ	JJ	_	13	amod	_	_
13	tool	tool	NN	NN	_	9	nmod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	diagnosis	diagnosis	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	subsequent	subsequent	JJ	JJ	_	18	amod	_	_
18	therapy	therapy	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	can	can	MD	MD	_	22	aux	_	_
22	provide	provide	VB	VB	_	9	conj	_	_
23	a	a	DT	DT	_	24	det	_	_
24	basis	basis	NN	NN	_	22	dobj	_	_
25	for	for	IN	IN	_	26	mark	_	_
26	distinguishing	distinguish	VBG	VBG	_	24	acl	_	_
27	heterozygous	heterozygous	JJ	JJ	_	28	amod	_	_
28	carriers	carrier	NNS	NNS	_	26	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	familial	familial	JJ	JJ	_	32	amod	_	_
31	androgen	androgen	NN	NN	_	32	compound	_	_
32	resistance	resistance	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	carriers	carrier	NNS	NNS	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	of	of	IN	IN	_	9	case	_	_
7	substantial	substantial	JJ	JJ	_	9	amod	_	_
8	clinical	clinical	JJ	JJ	_	9	amod	_	_
9	importance	importance	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	genetic	genetic	JJ	JJ	_	12	amod	_	_
12	counseling	counseling	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Minimally	minimally	RB	RB	_	5	advmod	_	_
2	modified	modify	VBN	VBN	_	5	dep	_	_
3	low	low	JJ	JJ	_	5	amod	_	_
4	density	density	NN	NN	_	5	nmod:npmod	_	_
5	lipoprotein-induced	lipoprotein-induced	JJ	JJ	_	7	amod	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	responses	response	NNS	NNS	_	12	nsubjpass	_	_
8	in	in	IN	IN	_	10	case	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	cyclic	cyclic	JJ	JJ	_	16	amod	_	_
15	adenosine	adenosine	NN	NN	_	16	compound	_	_
16	monophosphate	monophosphate	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	minimally	minimally	RB	RB	_	7	advmod	_	_
7	oxidized	oxidize	VBN	VBN	_	8	amod	_	_
8	LDL	ldl	NN	NN	_	12	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MM-LDL	mm-ldl	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	activated	activate	VBD	VBD	_	4	ccomp	_	_
13	endothelial	endothelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	12	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	increase	increase	VB	VB	_	12	advcl	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	interaction	interaction	NN	NN	_	16	dobj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	20	cc	_	_
23	neutrophils	neutrophil	NNS	NNS	_	20	conj	_	_
24	,	,	,	,	_	12	punct	_	_
25	inducing	induce	VBG	VBG	_	12	xcomp	_	_
26	monocyte	monocyte	NN	NN	_	25	dobj	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	26	cc	_	_
29	neutrophil	neutrophil	NN	NN	_	26	conj	_	_
30	binding	binding	NN	NN	_	26	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	synthesis	synthesis	NN	NN	_	30	conj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	monocyte	monocyte	NN	NN	_	36	compound	_	_
35	chemotactic	chemotactic	JJ	JJ	_	36	amod	_	_
36	protein-1	protein-1	NN	NN	_	26	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	monocyte	monocyte	NN	NN	_	40	compound	_	_
39	colony-stimulating	colony-stimulating	JJ	JJ	_	40	amod	_	_
40	factor	factor	NN	NN	_	36	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	M-CSF	m-csf	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	7	nmod	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	examined	examine	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	7	dobj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	17	nmod	_	_
13	this	this	DT	DT	_	15	det	_	_
14	monocyte-specific	monocyte-specific	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	10	acl:relcl	_	_
18	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	induction	induction	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	monocyte	monocyte	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	2	conj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	M-CSF	m-csf	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	MM-LDL	mm-ldl	NN	NN	_	2	nmod	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	inhibited	inhibit	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	21	case	_	_
17	protein	protein	NN	NN	_	19	nmod:npmod	_	_
18	kinase	kinase	NN	NN	_	19	nmod:npmod	_	_
19	C-depleted	c-depleted	JJ	JJ	_	21	amod	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	cAMP	camp	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	the	the	DT	DT	_	12	det	_	_
11	second	second	JJ	JJ	_	12	amod	_	_
12	messenger	messenger	NN	NN	_	6	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	MM-LDL	mm-ldl	NN	NN	_	15	nmod	_	_
18	cited	cite	VBN	VBN	_	15	acl	_	_
19	above	above	RB	RB	_	18	advmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Incubation	incubation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	endothelial	endothelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	MM-LDL	mm-ldl	NN	NN	_	1	nmod	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	173	173	CD	CD	_	10	compound	_	_
10	%	%	NN	NN	_	11	amod	_	_
11	increase	increase	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	intracellular	intracellular	JJ	JJ	_	15	amod	_	_
14	cAMP	camp	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Agents	agent	NNS	NNS	_	19	nsubj	_	_
2	which	which	WDT	WDT	_	3	nsubj	_	_
3	increased	increase	VBD	VBD	_	1	acl:relcl	_	_
4	cAMP	camp	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	including	include	VBG	VBG	_	9	case	_	_
8	cholera	cholera	NN	NN	_	9	compound	_	_
9	toxin	toxin	NN	NN	_	1	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	pertussis	pertussis	NN	NN	_	12	compound	_	_
12	toxin	toxin	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	dibutyryl	dibutyryl	NN	NN	_	15	compound	_	_
15	cAMP	camp	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	isoproterenol	isoproterenol	NN	NN	_	9	conj	_	_
19	mimicked	mimic	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	actions	action	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	MM-LDL	mm-ldl	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	Agents	agent	NNS	NNS	_	7	nsubjpass	_	_
2	which	which	WDT	WDT	_	3	nsubj	_	_
3	elevated	elevate	VBD	VBD	_	1	acl:relcl	_	_
4	cAMP	camp	NN	NN	_	3	dobj	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	xcomp	_	_
10	NF	nf	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	9	punct	_	_
14	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
15	a	a	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	for	for	IN	IN	_	20	case	_	_
18	this	this	DT	DT	_	20	det	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	monocyte-endothelial	monocyte-endothelial	JJ	JJ	_	25	amod	_	_
25	interactions	interaction	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
3	leukocyte	leukocyte	NN	NN	_	5	compound	_	_
4	adhesion	adhesion	NN	NN	_	5	compound	_	_
5	molecule	molecule	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ELAM	elam	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	synthesis	synthesis	NN	NN	_	13	nsubjpass	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	22	advcl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	NF	nf	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	ELAM	elam	NN	NN	_	22	nsubjpass	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	expressed	express	VBN	VBN	_	0	root	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	ELAM	elam	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	29	nsubj	_	_
26	was	be	VBD	VBD	_	29	aux	_	_
27	only	only	RB	RB	_	28	advmod	_	_
28	slightly	slightly	RB	RB	_	29	advmod	_	_
29	elevated	elevated	JJ	JJ	_	22	conj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	response	response	NN	NN	_	33	dep	_	_
32	to	to	TO	TO	_	33	case	_	_
33	MM-LDL	mm-ldl	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	induction	induction	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	LPS	lps	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	actually	actually	RB	RB	_	13	advmod	_	_
13	suppressed	suppress	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	agents	agent	NNS	NNS	_	13	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	elevated	elevate	VBD	VBD	_	15	acl:relcl	_	_
18	cAMP	camp	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	17	dobj	_	_
20	.	.	.	.	_	2	punct	_	_

1	Antisense	antisense	JJ	JJ	_	2	amod	_	_
2	oligonucleotides	oligonucleotide	NNS	NNS	_	10	nsubj	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	p65	p65	NN	NN	_	6	compound	_	_
6	subunit	subunit	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	block	block	VBP	VBP	_	0	root	_	_
11	CD11b	cd11b	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	alter	alter	VBP	VBP	_	10	conj	_	_
15	adhesion	adhesion	NN	NN	_	16	compound	_	_
16	properties	property	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	differentiated	differentiate	VBN	VBN	_	20	amod	_	_
19	HL-60	hl-60	NN	NN	_	20	compound	_	_
20	granulocytes	granulocyte	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	pleiotropic	pleiotropic	JJ	JJ	_	6	amod	_	_
6	regulator	regulator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	variety	variety	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	genes	gene	NNS	NNS	_	9	nmod	_	_
12	implicated	implicate	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	cellular	cellular	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	12	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	injury	injury	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	attributed	attribute	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	coordinated	coordinate	VBN	VBN	_	9	amod	_	_
9	binding	binding	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	subunits	subunit	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	distinct	distinct	JJ	JJ	_	17	amod	_	_
17	regions	region	NNS	NNS	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	promoter	promoter	JJ	JJ	_	21	amod	_	_
21	elements	element	NNS	NNS	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	numerous	numerous	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	growth	growth	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	receptors	receptor	NNS	NNS	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	adhesion	adhesion	NN	NN	_	35	compound	_	_
35	molecules	molecule	NNS	NNS	_	27	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Antisense	antisense	JJ	JJ	_	3	amod	_	_
2	phosphorothioate	phosphorothioate	JJ	JJ	_	3	amod	_	_
3	oligonucleotides	oligonucleotide	NNS	NNS	_	16	nsubjpass	_	_
4	to	to	TO	TO	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	p50	p50	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p65	p65	NN	NN	_	6	conj	_	_
9	subunits	subunit	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	9	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	used	use	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	define	define	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	physiologic	physiologic	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	this	this	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	resting	rest	VBG	VBG	_	30	amod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	stimulated	stimulate	VBN	VBN	_	27	conj	_	_
30	granulocytes	granulocyte	NNS	NNS	_	21	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	9	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p65	p65	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	produced	produce	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	treatment	treatment	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	phosphorothioate	phosphorothioate	JJ	JJ	_	16	amod	_	_
15	antisense	antisense	JJ	JJ	_	16	amod	_	_
16	oligodeoxynucleotide	oligodeoxynucleotide	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	rapid	rapid	JJ	JJ	_	7	amod	_	_
7	changes	change	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	adhesion	adhesion	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	dimethyl	dimethyl	JJ	JJ	_	14	amod	_	_
14	sulfoxide-differentiated	sulfoxide-differentiated	JJ	JJ	_	17	amod	_	_
15	HL-60	hl-60	NN	NN	_	17	compound	_	_
16	leukemia	leukemia	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	stimulated	stimulate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	12-O-tetradecanoylphorbol	12-o-tetradecanoylphorbol	NN	NN	_	21	compound	_	_
21	13-acetate	13-acetate	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	TPA	tpa	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	marked	marked	JJ	JJ	_	8	amod	_	_
8	reduction	reduction	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	CD11b	cd11b	NN	NN	_	12	compound	_	_
11	integrin	integrin	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	surface	surface	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	treated	treat	VBN	VBN	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	p65	p65	NN	NN	_	6	compound	_	_
5	antisense	antisense	JJ	JJ	_	6	amod	_	_
6	oligomer	oligomer	NN	NN	_	8	nsubj	_	_
7	effectively	effectively	RB	RB	_	8	advmod	_	_
8	abolished	abolish	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	10	det	_	_
10	upregulation	upregulation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD11b	cd11b	NN	NN	_	10	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	produced	produce	VBN	VBN	_	12	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	formyl-met-leu-phe	formyl-met-leu-phe	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	TPA	tpa	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	p65	p65	NN	NN	_	7	compound	_	_
5	antisense	antisense	JJ	JJ	_	7	amod	_	_
6	phosphorothioate	phosphorothioate	JJ	JJ	_	7	amod	_	_
7	oligodeoxynucleotide	oligodeoxynucleotide	NN	NN	_	8	nsubj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	11	neg	_	_
10	significant	significant	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	production	production	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	reactive	reactive	JJ	JJ	_	18	amod	_	_
17	oxygen	oxygen	NN	NN	_	18	compound	_	_
18	intermediates	intermediate	NNS	NNS	_	14	nmod	_	_
19	or	or	CC	CC	_	14	cc	_	_
20	on	on	IN	IN	_	21	case	_	_
21	phagocytosis	phagocytosis	NNS	NNS	_	14	conj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	antisense	antisense	JJ	JJ	_	6	amod	_	_
6	oligomers	oligomer	NNS	NNS	_	11	nsubjpass	_	_
7	to	to	TO	TO	_	8	case	_	_
8	p65	p65	NN	NN	_	6	nmod	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	used	use	VBN	VBN	_	3	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	define	define	VB	VB	_	11	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	role	role	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	activation	activation	NN	NN	_	22	compound	_	_
22	pathways	pathway	NNS	NNS	_	15	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	neutrophils	neutrophil	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Costimulation	costimulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	cAMP	camp	NN	NN	_	8	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	C	c	NN	NN	_	3	conj	_	_
8	pathways	pathway	NNS	NNS	_	1	nmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	14	det	_	_
11	CD3-dependent	cd3-dependent	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	9	dobj	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	leads	lead	VBZ	VBZ	_	9	conj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	persistent	persistent	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	AP-1	ap-1	NN	NN	_	25	compound	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	21	nsubjpass	_	_
3	mediated	mediate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	combined	combined	JJ	JJ	_	7	amod	_	_
7	stimulation	stimulation	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	18	case	_	_
9	cAMP-	camp-	NN	NN	_	18	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	protein	protein	NN	NN	_	17	nmod:npmod	_	_
12	kinase	kinase	NN	NN	_	17	nmod:npmod	_	_
13	C	c	NN	NN	_	17	nmod:npmod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	PKC	pkc	NN	NN	_	17	nmod:npmod	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	-dependent	-dependent	JJ	JJ	_	9	conj	_	_
18	pathways	pathway	NNS	NNS	_	7	nmod	_	_
19	have	have	VBP	VBP	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	investigated	investigate	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	different	different	JJ	JJ	_	25	amod	_	_
24	cellular	cellular	JJ	JJ	_	25	amod	_	_
25	systems	system	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	it	it	PRP	PRP	_	31	nsubjpass	_	_
29	has	have	VBZ	VBZ	_	31	aux	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	shown	show	VBN	VBN	_	21	conj	_	_
32	that	that	IN	IN	_	35	mark	_	_
33	they	they	PRP	PRP	_	35	nsubj	_	_
34	may	may	MD	MD	_	35	aux	_	_
35	complement	complement	VB	VB	_	31	ccomp	_	_
36	each	each	DT	DT	_	37	det	_	_
37	other	other	JJ	JJ	_	35	dobj	_	_
38	in	in	IN	IN	_	39	mark	_	_
39	activating	activate	VBG	VBG	_	35	advcl	_	_
40	cell	cell	NN	NN	_	39	dobj	_	_
41	proliferation	proliferation	NN	NN	_	40	dep	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	differentiation	differentiation	NN	NN	_	41	conj	_	_
44	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	upon	upon	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	stimulation	stimulation	NN	NN	_	16	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	both	both	DT	DT	_	13	det	_	_
13	pathways	pathway	NNS	NNS	_	10	nmod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubj	_	_
16	became	become	VBD	VBD	_	6	ccomp	_	_
17	refractory	refractory	JJ	JJ	_	16	xcomp	_	_
18	to	to	TO	TO	_	19	case	_	_
19	activation	activation	NN	NN	_	17	nmod	_	_
20	via	via	IN	IN	_	28	case	_	_
21	the	the	DT	DT	_	28	det	_	_
22	CD3/T	cd3/t	NN	NN	_	28	compound	_	_
23	cell	cell	NN	NN	_	28	compound	_	_
24	receptor	receptor	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	TcR	tcr	NN	NN	_	28	compound	_	_
27	)	)	-RRB-	-RRB-	_	28	punct	_	_
28	complex	complex	NN	NN	_	19	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	17	nsubj	_	_
3	preincubated	preincubate	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	7	case	_	_
5	phorbol	phorbol	NN	NN	_	7	compound	_	_
6	12-myristate	12-myristate	NN	NN	_	7	compound	_	_
7	13-acetate	13-acetate	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PMA	pma	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	dibutyryl	dibutyryl	NN	NN	_	13	compound	_	_
13	cAMP	camp	NN	NN	_	7	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Bt2cAMP	bt2camp	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	displayed	display	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	21	det	_	_
19	deficient	deficient	JJ	JJ	_	21	amod	_	_
20	proliferative	proliferative	JJ	JJ	_	21	amod	_	_
21	ability	ability	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	27	case	_	_
23	response	response	NN	NN	_	27	dep	_	_
24	to	to	TO	TO	_	27	case	_	_
25	anti-CD3	anti-cd3	JJ	JJ	_	27	amod	_	_
26	mAb	mab	NN	NN	_	27	compound	_	_
27	stimulation	stimulation	NN	NN	_	17	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	whereas	whereas	IN	IN	_	17	dep	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	38	nsubj	_	_
31	treated	treat	VBN	VBN	_	30	acl	_	_
32	individually	individually	RB	RB	_	31	advmod	_	_
33	with	with	IN	IN	_	35	case	_	_
34	either	either	CC	CC	_	35	cc:preconj	_	_
35	Bt2cAMP	bt2camp	NN	NN	_	31	nmod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	PMA	pma	NN	NN	_	35	conj	_	_
38	responded	respond	VBD	VBD	_	17	parataxis	_	_
39	comparably	comparably	RB	RB	_	38	advmod	_	_
40	to	to	TO	TO	_	42	case	_	_
41	untreated	untreated	JJ	JJ	_	42	amod	_	_
42	samples	sample	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	detected	detect	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	association	association	NN	NN	_	2	dobj	_	_
5	between	between	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	reduced	reduce	VBN	VBN	_	9	amod	_	_
8	mitogenic	mitogenic	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	interleukin-2	interleukin-2	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IL-2	il-2	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	chain	chain	NN	NN	_	15	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CD25	cd25	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	22	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	IL-2R	il-2r	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
4	Ca2+	ca2+	NN	NN	_	5	compound	_	_
5	mobilization	mobilization	NN	NN	_	1	nmod	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	CD3/TcR-dependent	cd3/tcr-dependent	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	13	nsubj	_	_
12	was	be	VBD	VBD	_	13	aux	_	_
13	impaired	impaired	JJ	JJ	_	6	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	PMA/Bt2cAMP-treated	pma/bt2camp-treated	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Remarkably	remarkably	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observed	observe	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	these	these	DT	DT	_	7	det	_	_
7	samples	sample	NNS	NNS	_	8	nsubj	_	_
8	displayed	display	VBD	VBD	_	4	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	persistent	persistent	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	c-fos	c-fos	NN	NN	_	15	compound	_	_
15	protooncogene	protooncogene	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	associated	associate	VBN	VBN	_	11	acl	_	_
18	to	to	TO	TO	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	increased	increase	VBN	VBN	_	23	amod	_	_
21	AP-1	ap-1	NN	NN	_	23	compound	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	17	nmod	_	_
24	,	,	,	,	_	4	punct	_	_
25	whereas	whereas	IN	IN	_	4	dep	_	_
26	no	no	DT	DT	_	27	neg	_	_
27	variations	variation	NNS	NNS	_	33	nsubjpass	_	_
28	of	of	IN	IN	_	29	case	_	_
29	CREB	creb	NN	NN	_	27	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	NF-kB	nf-kb	NN	NN	_	29	conj	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	detected	detect	VBN	VBN	_	4	parataxis	_	_
34	.	.	.	.	_	4	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	Bt2cAMP	bt2camp	NN	NN	_	6	nsubj	_	_
3	nor	nor	CC	CC	_	2	cc	_	_
4	PMA	pma	NN	NN	_	2	conj	_	_
5	individually	individually	RB	RB	_	6	advmod	_	_
6	mediated	mediate	VBD	VBD	_	0	root	_	_
7	these	these	DT	DT	_	9	det	_	_
8	sustained	sustained	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubj	_	_
12	therefore	therefore	RB	RB	_	13	advmod	_	_
13	appear	appear	VBP	VBP	_	9	acl:relcl	_	_
14	as	as	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	consequence	consequence	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	interplay	interplay	NN	NN	_	16	nmod	_	_
20	between	between	IN	IN	_	23	case	_	_
21	both	both	DT	DT	_	23	det	_	_
22	metabolic	metabolic	JJ	JJ	_	23	amod	_	_
23	stimuli	stimulus	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	evidence	evidence	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	both	both	DT	DT	_	10	det	_	_
10	pathways	pathway	NNS	NNS	_	11	nsubj	_	_
11	complement	complement	VBP	VBP	_	7	ccomp	_	_
12	each	each	DT	DT	_	13	det	_	_
13	other	other	JJ	JJ	_	11	dobj	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	regulating	regulate	VBG	VBG	_	11	advcl	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	,	,	,	,	_	11	punct	_	_
20	conversely	conversely	RB	RB	_	22	advmod	_	_
21	,	,	,	,	_	22	punct	_	_
22	downregulate	downregulate	VBP	VBP	_	11	conj	_	_
23	the	the	DT	DT	_	26	det	_	_
24	TcR	tcr	NN	NN	_	26	compound	_	_
25	transduction	transduction	NN	NN	_	26	compound	_	_
26	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	mediator	mediator	NN	NN	_	4	appos	_	_
8	of	of	IN	IN	_	10	case	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	10	compound	_	_
10	effects	effect	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Exposure	exposure	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	certain	certain	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	types	type	NNS	NNS	_	1	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	bacterial	bacterial	JJ	JJ	_	8	amod	_	_
8	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LPS	lps	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	leads	lead	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	19	punct	_	_
25	an	a	DT	DT	_	28	det	_	_
26	inducible	inducible	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	19	appos	_	_
29	.	.	.	.	_	12	punct	_	_

1	One	one	CD	CD	_	11	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	7	nmod:poss	_	_
5	's	's	POS	POS	_	4	case	_	_
6	unique	unique	JJ	JJ	_	7	amod	_	_
7	properties	property	NNS	NNS	_	1	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	posttranslational	posttranslational	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	0	root	_	_
12	via	via	IN	IN	_	13	case	_	_
13	release	release	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	inhibitory	inhibitory	JJ	JJ	_	17	amod	_	_
17	subunit	subunit	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	called	call	VBN	VBN	_	17	acl	_	_
20	inhibitor	inhibitor	NN	NN	_	19	xcomp	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	27	punct	_	_
25	I	i	NN	NN	_	27	compound	_	_
26	kappa	kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	20	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	17	punct	_	_
30	from	from	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	sequestered	sequestered	JJ	JJ	_	34	amod	_	_
33	cytoplasmic	cytoplasmic	JJ	JJ	_	34	amod	_	_
34	form	form	NN	NN	_	13	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	event	event	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	triggered	trigger	VBN	VBN	_	0	root	_	_
6	under	under	IN	IN	_	9	case	_	_
7	various	various	JJ	JJ	_	9	amod	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	conditions	condition	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	biomedical	biomedical	JJ	JJ	_	12	amod	_	_
12	importance	importance	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Other	other	JJ	JJ	_	3	amod	_	_
2	bacterial	bacterial	JJ	JJ	_	3	amod	_	_
3	toxins	toxin	NNS	NNS	_	30	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	necrosis	necrosis	NN	NN	_	7	compound	_	_
7	factor-alpha	factor-alpha	NN	NN	_	3	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	TNF	tnf	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	3	punct	_	_
12	interleukin-1	interleukin-1	NN	NN	_	3	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IL-1	il-1	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	3	punct	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	mitogens	mitogen	NNS	NNS	_	3	conj	_	_
20	,	,	,	,	_	3	punct	_	_
21	UV	uv	NN	NN	_	22	compound	_	_
22	light	light	NN	NN	_	3	conj	_	_
23	,	,	,	,	_	3	punct	_	_
24	gamma	gamma	NN	NN	_	25	compound	_	_
25	rays	ray	NNS	NNS	_	3	conj	_	_
26	and	and	CC	CC	_	3	cc	_	_
27	oxidative	oxidative	JJ	JJ	_	28	amod	_	_
28	stress	stress	NN	NN	_	3	conj	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	reported	report	VBN	VBN	_	0	root	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	induce	induce	VB	VB	_	30	xcomp	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	activated	activated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	which	which	WDT	WDT	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	rapidly	rapidly	RB	RB	_	11	advmod	_	_
11	taken	take	VBN	VBN	_	3	acl:relcl	_	_
12	up	up	RP	RP	_	11	compound:prt	_	_
13	into	into	IN	IN	_	14	case	_	_
14	nuclei	nucleus	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	initiates	initiate	VBZ	VBZ	_	0	root	_	_
17	transcription	transcription	NN	NN	_	16	dobj	_	_
18	from	from	IN	IN	_	21	case	_	_
19	immediate	immediate	JJ	JJ	_	21	amod	_	_
20	early	early	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	wide	wide	JJ	JJ	_	25	amod	_	_
25	variety	variety	NN	NN	_	17	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	types	type	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	Most	most	JJS	JJS	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	target	target	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	nmod	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	of	of	IN	IN	_	11	case	_	_
11	relevance	relevance	NN	NN	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	grouped	group	VBN	VBN	_	11	conj	_	_
20	into	into	IN	IN	_	21	case	_	_
21	those	those	DT	DT	_	19	nmod	_	_
22	encoding	encoding	JJ	JJ	_	21	dep	_	_
23	cytokines	cytokine	NNS	NNS	_	22	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	surface	surface	NN	NN	_	27	compound	_	_
27	receptors	receptor	NNS	NNS	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	acute	acute	JJ	JJ	_	31	amod	_	_
30	phase	phase	NN	NN	_	31	compound	_	_
31	proteins	protein	NNS	NNS	_	23	conj	_	_
32	and	and	CC	CC	_	23	cc	_	_
33	viral	viral	JJ	JJ	_	34	amod	_	_
34	genomes	genome	NNS	NNS	_	23	conj	_	_
35	,	,	,	,	_	21	punct	_	_
36	such	such	JJ	JJ	_	38	case	_	_
37	as	as	IN	IN	_	36	mwe	_	_
38	that	that	DT	DT	_	21	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	human	human	JJ	JJ	_	43	amod	_	_
41	immunodeficiency	immunodeficiency	NN	NN	_	43	compound	_	_
42	virus	virus	NN	NN	_	43	compound	_	_
43	type	type	NN	NN	_	38	nmod	_	_
44	1	1	CD	CD	_	43	nummod	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	HIV-1	hiv-1	NN	NN	_	43	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	will	will	MD	MD	_	3	aux	_	_
3	discuss	discuss	VB	VB	_	0	root	_	_
4	recent	recent	JJ	JJ	_	6	amod	_	_
5	experimental	experimental	JJ	JJ	_	6	amod	_	_
6	evidences	evidence	NNS	NNS	_	3	dobj	_	_
7	suggesting	suggest	VBG	VBG	_	6	acl	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	LPS	lps	NN	NN	_	11	nsubj	_	_
10	might	might	MD	MD	_	11	aux	_	_
11	share	share	VB	VB	_	7	ccomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	pathway	pathway	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	other	other	JJ	JJ	_	20	amod	_	_
20	inducers	inducer	NNS	NNS	_	11	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	factor	factor	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	common	common	JJ	JJ	_	3	amod	_	_
3	pathway	pathway	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	involve	involve	VB	VB	_	0	root	_	_
6	reactive	reactive	JJ	JJ	_	8	amod	_	_
7	oxygen	oxygen	NN	NN	_	8	compound	_	_
8	intermediates	intermediate	NNS	NNS	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ROI	roi	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	as	as	IN	IN	_	14	case	_	_
13	messenger	messenger	NN	NN	_	14	compound	_	_
14	molecules	molecule	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	T	t	NN	NN	_	6	compound	_	_
3	cell	cell	NN	NN	_	6	compound	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	GATA-3	gata-3	NN	NN	_	7	nsubj	_	_
7	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	family	family	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
5	activating	activate	VBG	VBG	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	2	appos	_	_
11	,	,	,	,	_	2	punct	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	bind	bind	VB	VB	_	14	xcomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	consensus	consensus	NN	NN	_	20	compound	_	_
20	motif	motif	NN	NN	_	16	nmod	_	_
21	through	through	IN	IN	_	30	case	_	_
22	a	a	DT	DT	_	30	det	_	_
23	highly	highly	RB	RB	_	24	advmod	_	_
24	conserved	conserve	VBN	VBN	_	30	amod	_	_
25	C4	c4	NN	NN	_	30	compound	_	_
26	zinc	zinc	NN	NN	_	30	compound	_	_
27	finger	finger	NN	NN	_	30	compound	_	_
28	DNA	dna	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	domain	domain	NN	NN	_	16	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	member	member	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	multigene	multigene	JJ	JJ	_	6	amod	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	GATA-3	gata-3	NN	NN	_	2	appos	_	_
9	,	,	,	,	_	2	punct	_	_
10	is	be	VBZ	VBZ	_	13	auxpass	_	_
11	most	most	RBS	RBS	_	12	advmod	_	_
12	abundantly	abundantly	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	cellular	cellular	JJ	JJ	_	20	amod	_	_
20	target	target	NN	NN	_	16	appos	_	_
21	for	for	IN	IN	_	25	case	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	immunodeficiency	immunodeficiency	NN	NN	_	25	compound	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	type	type	NN	NN	_	20	nmod	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	HIV-1	hiv-1	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	infection	infection	NN	NN	_	25	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	replication	replication	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	13	punct	_	_

1	In	in	FW	FW	_	6	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	DNase	dnase	NN	NN	_	6	compound	_	_
4	I	i	CD	CD	_	6	nummod	_	_
5	footprinting	footprinting	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	7	nsubj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	six	six	CD	CD	_	11	nummod	_	_
9	hGATA-3	hgata-3	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	7	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	U3	u3	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	the	the	DT	DT	_	20	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	15	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	HIV-1	hiv-1	NN	NN	_	25	compound	_	_
25	LTR	ltr	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	an	a	DT	DT	_	6	det	_	_
4	hGATA-3	hgata-3	NN	NN	_	6	compound	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	plasmid	plasmid	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	plasmid	plasmid	NN	NN	_	1	nmod	_	_
11	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
12	transcription	transcription	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	directed	direct	VBN	VBN	_	10	acl:relcl	_	_
15	by	by	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
18	LTR	ltr	NN	NN	_	14	nmod	_	_
19	resulted	result	VBD	VBD	_	0	root	_	_
20	in	in	IN	IN	_	24	case	_	_
21	6-	6-	CD	CD	_	24	nummod	_	_
22	to	to	TO	TO	_	21	dep	_	_
23	10-fold	10-fold	JJ	JJ	_	21	advmod	_	_
24	stimulation	stimulation	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	LTR-mediated	ltr-mediated	JJ	JJ	_	27	amod	_	_
27	transcription	transcription	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	19	punct	_	_
29	whereas	whereas	IN	IN	_	19	dep	_	_
30	site	site	NN	NN	_	31	nmod:npmod	_	_
31	specific	specific	JJ	JJ	_	32	amod	_	_
32	mutation	mutation	NN	NN	_	37	nsubj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	these	these	DT	DT	_	36	det	_	_
35	GATA	gata	NN	NN	_	36	compound	_	_
36	sites	site	NNS	NNS	_	32	nmod	_	_
37	resulted	result	VBD	VBD	_	19	parataxis	_	_
38	in	in	IN	IN	_	40	case	_	_
39	virtual	virtual	JJ	JJ	_	40	amod	_	_
40	abrogation	abrogation	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	the	the	DT	DT	_	43	det	_	_
43	activation	activation	NN	NN	_	40	nmod	_	_
44	by	by	IN	IN	_	45	case	_	_
45	hGATA-3	hgata-3	NN	NN	_	43	nmod	_	_
46	.	.	.	.	_	19	punct	_	_

1	Further	further	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	deletion	deletion	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	hGATA-3	hgata-3	NN	NN	_	9	compound	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	activation	activation	NN	NN	_	9	compound	_	_
9	domain	domain	NN	NN	_	3	nmod	_	_
10	abolished	abolish	VBD	VBD	_	0	root	_	_
11	GATA-dependent	gata-dependent	JJ	JJ	_	13	amod	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	trans-activation	trans-activation	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	10	punct	_	_
15	showing	show	VBG	VBG	_	10	advcl	_	_
16	that	that	IN	IN	_	26	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	stimulation	stimulation	NN	NN	_	26	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	18	nmod	_	_
22	observed	observe	VBN	VBN	_	21	acl	_	_
23	is	be	VBZ	VBZ	_	26	cop	_	_
24	a	a	DT	DT	_	26	det	_	_
25	direct	direct	JJ	JJ	_	26	amod	_	_
26	effect	effect	NN	NN	_	15	ccomp	_	_
27	of	of	IN	IN	_	29	case	_	_
28	cotransfected	cotransfect	VBN	VBN	_	29	amod	_	_
29	hGATA-3	hgata-3	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Introduction	introduction	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	plasmids	plasmid	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	13	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	13	nsubjpass	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	mutated	mutate	VBN	VBN	_	5	acl:relcl	_	_
14	into	into	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	caused	cause	VBD	VBD	_	0	root	_	_
20	a	a	DT	DT	_	22	det	_	_
21	significant	significant	JJ	JJ	_	22	amod	_	_
22	reduction	reduction	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	LTR-mediated	ltr-mediated	JJ	JJ	_	25	amod	_	_
25	transcription	transcription	NN	NN	_	22	nmod	_	_
26	at	at	IN	IN	_	30	case	_	_
27	both	both	CC	CC	_	30	dep	_	_
28	the	the	DT	DT	_	30	det	_	_
29	basal	basal	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	19	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	in	in	IN	IN	_	40	case	_	_
33	(	(	-LRB-	-LRB-	_	38	punct	_	_
34	PHA-	pha-	NN	NN	_	38	dep	_	_
35	plus	plus	CC	CC	_	34	cc	_	_
36	PMA-	pma-	NN	NN	_	34	conj	_	_
37	)	)	-RRB-	-RRB-	_	38	punct	_	_
38	stimulated	stimulated	JJ	JJ	_	40	amod	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	30	conj	_	_
41	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	in	in	IN	IN	_	10	case	_	_
6	addition	addition	NN	NN	_	10	dep	_	_
7	to	to	TO	TO	_	10	case	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	20	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	T	t	NN	NN	_	15	compound	_	_
13	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	regulation	regulation	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	hGATA-3	hgata-3	NN	NN	_	20	nsubj	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	play	play	VB	VB	_	3	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	significant	significant	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	activation	activation	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	preexisting	preexisting	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	nuclear	nuclear	JJ	JJ	_	4	conj	_	_
7	forms	form	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	activated	activate	VBN	VBN	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NF-AT	nf-at	NN	NN	_	3	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	3	3	CD	CD	_	3	nummod	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	an	a	DT	DT	_	16	det	_	_
14	inducible	inducible	JJ	JJ	_	16	amod	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	0	root	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	essential	essential	JJ	JJ	_	16	acl:relcl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	induction	induction	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IL-2	il-2	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	during	during	IN	IN	_	30	case	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	NF-AT	nf-at	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	thought	think	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	consist	consist	VB	VB	_	3	xcomp	_	_
6	of	of	IN	IN	_	8	case	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	components	component	NNS	NNS	_	5	nmod	_	_
9	:	:	:	:	_	8	punct	_	_
10	a	a	DT	DT	_	15	det	_	_
11	ubiquitous	ubiquitous	JJ	JJ	_	15	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	inducible	inducible	JJ	JJ	_	11	dep	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	component	component	NN	NN	_	8	dep	_	_
16	that	that	WDT	WDT	_	19	dobj	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	identified	identify	VBN	VBN	_	15	acl:relcl	_	_
20	as	as	IN	IN	_	24	case	_	_
21	Fos	fos	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Jun	jun	NN	NN	_	21	conj	_	_
24	proteins	protein	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	a	a	DT	DT	_	32	det	_	_
28	preexisting	preexist	VBG	VBG	_	32	amod	_	_
29	,	,	,	,	_	28	punct	_	_
30	T	t	NN	NN	_	31	nmod:npmod	_	_
31	cell-specific	cell-specific	JJ	JJ	_	28	dep	_	_
32	component	component	NN	NN	_	15	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	NF-ATp	nf-atp	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	which	which	WDT	WDT	_	39	nsubj	_	_
37	is	be	VBZ	VBZ	_	39	cop	_	_
38	the	the	DT	DT	_	39	det	_	_
39	target	target	NN	NN	_	32	acl:relcl	_	_
40	for	for	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	immunosuppressive	immunosuppressive	JJ	JJ	_	43	amod	_	_
43	agents	agent	NNS	NNS	_	39	nmod	_	_
44	cyclosporin	cyclosporin	NN	NN	_	45	compound	_	_
45	A	a	NN	NN	_	43	dep	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	CsA	csa	NN	NN	_	45	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	FK506	fk506	NN	NN	_	45	conj	_	_
51	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	12	nsubj	_	_
8	from	from	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	form	form	VBP	VBP	_	4	ccomp	_	_
13	two	two	CD	CD	_	16	nummod	_	_
14	inducible	inducible	JJ	JJ	_	16	amod	_	_
15	NF-AT	nf-at	NN	NN	_	16	compound	_	_
16	complexes	complex	NNS	NNS	_	12	dobj	_	_
17	with	with	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	oligonucleotide	oligonucleotide	NN	NN	_	16	nmod	_	_
20	corresponding	correspond	VBG	VBG	_	19	acl	_	_
21	to	to	TO	TO	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	distal	distal	JJ	JJ	_	25	amod	_	_
24	NF-AT	nf-at	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	murine	murine	JJ	JJ	_	30	amod	_	_
29	IL-2	il-2	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	25	nmod	_	_
31	,	,	,	,	_	12	punct	_	_
32	although	although	IN	IN	_	39	mark	_	_
33	hypotonic	hypotonic	JJ	JJ	_	34	amod	_	_
34	extracts	extract	NNS	NNS	_	39	nsubj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	unstimulated	unstimulated	JJ	JJ	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	34	nmod	_	_
39	form	form	VBP	VBP	_	12	advcl	_	_
40	a	a	DT	DT	_	42	det	_	_
41	single	single	JJ	JJ	_	42	amod	_	_
42	complex	complex	NN	NN	_	39	dobj	_	_
43	containing	contain	VBG	VBG	_	42	acl	_	_
44	NF-ATp	nf-atp	NN	NN	_	43	dobj	_	_
45	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	29	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ability	ability	NN	NN	_	29	nsubj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	detect	detect	VB	VB	_	5	acl	_	_
8	NF-ATp	nf-atp	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	gel	gel	NN	NN	_	13	compound	_	_
12	shift	shift	NN	NN	_	13	compound	_	_
13	assay	assay	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	essential	essential	JJ	JJ	_	5	acl:relcl	_	_
18	for	for	IN	IN	_	19	case	_	_
19	purification	purification	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	biochemical	biochemical	JJ	JJ	_	22	amod	_	_
22	studies	study	NNS	NNS	_	19	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	protein	protein	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	5	punct	_	_
27	is	be	VBZ	VBZ	_	29	cop	_	_
28	strikingly	strikingly	RB	RB	_	29	advmod	_	_
29	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
30	on	on	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	precise	precise	JJ	JJ	_	33	amod	_	_
33	sequence	sequence	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	NF-AT	nf-at	NN	NN	_	37	compound	_	_
37	oligonucleotide	oligonucleotide	NN	NN	_	33	nmod	_	_
38	used	use	VBN	VBN	_	37	acl	_	_
39	as	as	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	labeled	labeled	JJ	JJ	_	42	amod	_	_
42	probe	probe	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Moreover	moreover	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	present	present	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	component	component	NN	NN	_	20	nsubjpass	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	forms	form	VBZ	VBZ	_	7	acl:relcl	_	_
10	the	the	DT	DT	_	18	det	_	_
11	faster-migrating	faster-migrating	JJ	JJ	_	18	amod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	``	``	``	``	_	14	punct	_	_
14	lower	lower	JJR	JJR	_	11	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	NF-AT	nf-at	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	9	dobj	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	derived	derive	VBN	VBN	_	4	ccomp	_	_
21	by	by	IN	IN	_	28	case	_	_
22	a	a	DT	DT	_	28	det	_	_
23	calcium-dependent	calcium-dependent	JJ	JJ	_	28	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	cyclosporin-sensitive	cyclosporin-sensitive	JJ	JJ	_	23	dep	_	_
26	,	,	,	,	_	23	punct	_	_
27	posttranslational	posttranslational	JJ	JJ	_	23	dep	_	_
28	modification	modification	NN	NN	_	20	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	NF-ATp	nf-atp	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	20	punct	_	_
32	and	and	CC	CC	_	20	cc	_	_
33	that	that	IN	IN	_	38	mark	_	_
34	Fos	fos	NN	NN	_	37	compound	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	Jun	jun	NN	NN	_	34	conj	_	_
37	proteins	protein	NNS	NNS	_	38	nsubj	_	_
38	stabilize	stabilize	VBP	VBP	_	20	conj	_	_
39	its	its	PRP$	PRP$	_	40	nmod:poss	_	_
40	interaction	interaction	NN	NN	_	38	dobj	_	_
41	with	with	IN	IN	_	42	case	_	_
42	DNA	dna	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	discussed	discuss	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	context	context	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	model	model	NN	NN	_	7	nmod	_	_
11	relating	relate	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	16	det	_	_
13	two	two	CD	CD	_	16	nummod	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	NF-AT	nf-at	NN	NN	_	16	compound	_	_
16	complexes	complex	NNS	NNS	_	11	dobj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	NF-ATp	nf-atp	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Enhancing	enhancing	NN	NN	_	2	compound	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	17	17	CD	CD	_	5	nummod	_	_
5	beta-estradiol	beta-estradiol	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	NK	nk	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	effect	effect	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	17	17	CD	CD	_	7	nummod	_	_
7	beta-estradiol	beta-estradiol	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	NK	nk	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	4	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	studied	study	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proliferation	proliferation	NN	NN	_	16	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NK	nk	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	YT-N17	yt-n17	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	a	a	DT	DT	_	13	det	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	NK-like	nk-like	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	7	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	enhanced	enhance	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	17	17	CD	CD	_	19	nummod	_	_
19	beta-estradiol	beta-estradiol	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	E2	e2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	16	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	enhancement	enhancement	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	blocked	block	VBN	VBN	_	16	conj	_	_
29	by	by	IN	IN	_	30	case	_	_
30	tamoxifen	tamoxifen	NN	NN	_	28	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	Tx	tx	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	30	punct	_	_
35	an	a	DT	DT	_	36	det	_	_
36	antagonist	antagonist	NN	NN	_	30	appos	_	_
37	of	of	IN	IN	_	38	case	_	_
38	E2	e2	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	16	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	contrary	contrary	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	other	other	JJ	JJ	_	7	amod	_	_
6	steroid	steroid	NN	NN	_	7	compound	_	_
7	hormones	hormone	NNS	NNS	_	16	nsubj	_	_
8	such	such	JJ	JJ	_	10	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	Tx	tx	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	progesterone	progesterone	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	testosterone	testosterone	NN	NN	_	10	conj	_	_
16	had	have	VBD	VBD	_	0	root	_	_
17	no	no	DT	DT	_	18	neg	_	_
18	effect	effect	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	16	punct	_	_

1	YT-N17	yt-n17	NN	NN	_	2	nsubj	_	_
2	contained	contain	VBD	VBD	_	0	root	_	_
3	11.8	11.8	CD	CD	_	4	compound	_	_
4	fmol/mg	fmol/mg	NN	NN	_	5	amod	_	_
5	protein	protein	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	estrogen	estrogen	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	mean	mean	NN	NN	_	5	dep	_	_
11	of	of	IN	IN	_	14	case	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	independent	independent	JJ	JJ	_	14	amod	_	_
14	assays	assay	NNS	NNS	_	10	nmod	_	_
15	)	)	-RRB-	-RRB-	_	10	punct	_	_
16	,	,	,	,	_	5	punct	_	_
17	a	a	DT	DT	_	18	det	_	_
18	value	value	NN	NN	_	5	appos	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	5-10-fold	5-10-fold	RB	RB	_	22	advmod	_	_
22	higher	higher	JJR	JJR	_	18	acl:relcl	_	_
23	than	than	IN	IN	_	24	case	_	_
24	that	that	DT	DT	_	22	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	other	other	JJ	JJ	_	29	amod	_	_
27	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	enhancement	enhancement	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NK	nk	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	E2	e2	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	seen	see	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	large	large	JJ	JJ	_	14	amod	_	_
13	granular	granular	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	obtained	obtain	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	subjects	subject	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	it	it	PRP	PRP	_	24	nsubjpass	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	again	again	RB	RB	_	24	advmod	_	_
24	suppressed	suppress	VBN	VBN	_	10	conj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	Tx	tx	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	E2	e2	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	one	one	CD	CD	_	3	ccomp	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	activating	activate	VBG	VBG	_	11	amod	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	NK/LGL	nk/lgl	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	modulation	modulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	29	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	peptide	peptide	NN	NN	_	5	compound	_	_
5	hormones	hormone	NNS	NNS	_	1	appos	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	control	control	VBP	VBP	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	homeostasis	homeostasis	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	also	also	RB	RB	_	7	advmod	_	_
16	play	play	VBP	VBP	_	7	dep	_	_
17	a	a	DT	DT	_	19	det	_	_
18	fundamental	fundamental	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	inflammatory	inflammatory	JJ	JJ	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	immune	immune	JJ	JJ	_	24	amod	_	_
24	mediated	mediated	JJ	JJ	_	21	conj	_	_
25	reactions	reaction	NNS	NNS	_	16	nmod	_	_
26	,	,	,	,	_	1	punct	_	_
27	have	have	VBP	VBP	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	involved	involve	VBN	VBN	_	0	root	_	_
30	at	at	IN	IN	_	32	case	_	_
31	multiple	multiple	JJ	JJ	_	32	amod	_	_
32	levels	level	NNS	NNS	_	29	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	pathogenesis	pathogenesis	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	41	case	_	_
37	the	the	DT	DT	_	41	det	_	_
38	acquired	acquire	VBN	VBN	_	41	amod	_	_
39	immune	immune	JJ	JJ	_	41	amod	_	_
40	deficiency	deficiency	NN	NN	_	41	compound	_	_
41	syndrome	syndrome	NN	NN	_	35	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	AIDS	aids	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	29	punct	_	_

1	Infection	infection	NN	NN	_	12	nsubjpass	_	_
2	with	with	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	virus	virus	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV	hiv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	induce	induce	VB	VB	_	12	xcomp	_	_
15	production	production	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
19	both	both	CC	CC	_	22	cc:preconj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vitro	vitro	FW	FW	_	22	advmod	_	_
22	and	and	CC	CC	_	14	advmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vivo	vivo	FW	FW	_	22	advmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	Conversely	conversely	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	several	several	JJ	JJ	_	4	amod	_	_
4	cytokines	cytokine	NNS	NNS	_	5	nsubj	_	_
5	modulate	modulate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	infected	infected	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	21	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	T	t	NN	NN	_	17	nmod:npmod	_	_
17	lymphocytic	lymphocytic	JJ	JJ	_	21	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
20	phagocytic	phagocytic	JJ	JJ	_	17	conj	_	_
21	lineage	lineage	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	mononuclear	mononuclear	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	21	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	particularly	particularly	RB	RB	_	7	advmod	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	appos	_	_
8	which	which	WDT	WDT	_	12	nsubj	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	in	in	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	state	state	NN	NN	_	7	acl:relcl	_	_
13	of	of	IN	IN	_	15	case	_	_
14	chronic	chronic	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	HIV	hiv	NN	NN	_	18	nmod:npmod	_	_
18	infected	infected	JJ	JJ	_	19	amod	_	_
19	individuals	individual	NNS	NNS	_	12	nmod	_	_
20	,	,	,	,	_	3	punct	_	_
21	release	release	VBP	VBP	_	0	root	_	_
22	HIV-inductive	hiv-inductive	JJ	JJ	_	23	amod	_	_
23	cytokines	cytokine	NNS	NNS	_	21	dobj	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	thus	thus	RB	RB	_	21	advmod	_	_
26	play	play	VBP	VBP	_	21	dep	_	_
27	a	a	DT	DT	_	30	det	_	_
28	potentially	potentially	RB	RB	_	29	advmod	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	role	role	NN	NN	_	26	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	pathogenesis	pathogenesis	NN	NN	_	26	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	HIV	hiv	NN	NN	_	36	compound	_	_
36	infection	infection	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	21	punct	_	_

1	Tumor	tumor	NN	NN	_	5	compound	_	_
2	necrosis	necrosis	NN	NN	_	5	compound	_	_
3	factor	factor	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transduction	transduction	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	HIV-1-infected	hiv-1-infected	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	4	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	examine	examine	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inter-relationship	inter-relationship	NN	NN	_	4	dobj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	infection	infection	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	14	det	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	conj	_	_
15	for	for	IN	IN	_	22	case	_	_
16	tumor	tumor	NN	NN	_	22	compound	_	_
17	necrosis	necrosis	NN	NN	_	22	compound	_	_
18	factor	factor	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	TNF	tnf	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	-alpha	-alpha	NN	NN	_	14	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	an	a	DT	DT	_	26	det	_	_
25	immunoregulatory	immunoregulatory	JJ	JJ	_	26	amod	_	_
26	cytokine	cytokine	NN	NN	_	22	appos	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	can	can	MD	MD	_	29	aux	_	_
29	enhance	enhance	VB	VB	_	26	acl:relcl	_	_
30	HIV-1	hiv-1	NN	NN	_	31	compound	_	_
31	replication	replication	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	4	punct	_	_

1	DESIGN	design	NN	NN	_	9	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	Infected	infected	JJ	JJ	_	7	amod	_	_
4	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	promonocytic	promonocytic	JJ	JJ	_	4	conj	_	_
7	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	examined	examine	VBN	VBN	_	0	root	_	_
10	because	because	IN	IN	_	13	mark	_	_
11	they	they	PRP	PRP	_	13	nsubj	_	_
12	normally	normally	RB	RB	_	13	advmod	_	_
13	express	express	VBP	VBP	_	9	advcl	_	_
14	both	both	DT	DT	_	15	det	_	_
15	types	type	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	TNF	tnf	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	METHODS	method	NNS	NNS	_	8	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	TNF	tnf	NN	NN	_	6	compound	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	determined	determine	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	specific	specific	JJ	JJ	_	13	amod	_	_
11	monoclonal	monoclonal	JJ	JJ	_	13	amod	_	_
12	antibody	antibody	NN	NN	_	13	compound	_	_
13	recognition	recognition	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	flow	flow	NN	NN	_	16	compound	_	_
16	cytometry	cytometry	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	transduction	transduction	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	detected	detect	VBN	VBN	_	8	conj	_	_
23	by	by	IN	IN	_	26	case	_	_
24	gel	gel	NN	NN	_	26	compound	_	_
25	shift	shift	NN	NN	_	26	compound	_	_
26	analysis	analysis	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	6	nsubjpass	_	_
2	activation	activation	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	expression	expression	NN	NN	_	2	conj	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	quantitated	quantitate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	reverse	reverse	JJ	JJ	_	10	amod	_	_
9	transcriptase	transcriptase	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	RESULTS	result	NNS	NNS	_	16	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	OM-10.1	om-10.1	NN	NN	_	7	compound	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
7	model	model	NN	NN	_	16	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	chronic	chronic	JJ	JJ	_	10	amod	_	_
10	infection	infection	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	16	punct	_	_
12	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	14	amod	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	16	nsubj	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	resulted	result	VBD	VBD	_	0	root	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	substantial	substantial	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	29	case	_	_
22	75	75	CD	CD	_	25	nummod	_	_
23	kd	kd	NN	NN	_	25	compound	_	_
24	TNF	tnf	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	TR75	tr75	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	expression	expression	NN	NN	_	20	nmod	_	_
30	although	although	IN	IN	_	42	mark	_	_
31	55	55	CD	CD	_	34	nummod	_	_
32	kD	kd	NN	NN	_	34	compound	_	_
33	TNF	tnf	NN	NN	_	34	compound	_	_
34	receptor	receptor	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	TR55	tr55	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	levels	level	NNS	NNS	_	42	nsubjpass	_	_
39	were	be	VBD	VBD	_	42	auxpass	_	_
40	not	not	RB	RB	_	42	neg	_	_
41	dramatically	dramatically	RB	RB	_	42	advmod	_	_
42	altered	alter	VBN	VBN	_	16	advcl	_	_
43	.	.	.	.	_	16	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	series	series	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	uninfected	uninfected	JJ	JJ	_	7	amod	_	_
5	parental	parental	JJ	JJ	_	7	amod	_	_
6	HL-60	hl-60	NN	NN	_	7	compound	_	_
7	subclones	subclone	NNS	NNS	_	2	nmod	_	_
8	all	all	DT	DT	_	2	advmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	TR75	tr75	NN	NN	_	12	compound	_	_
11	surface	surface	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	response	response	NN	NN	_	17	dep	_	_
15	to	to	TO	TO	_	17	case	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	3	amod	_	_
2	TR75	tr75	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	7	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	OM-10.1	om-10.1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	followed	follow	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	same	same	JJ	JJ	_	11	amod	_	_
10	TNF-alpha-dose	tnf-alpha-dose	NN	NN	_	11	compound	_	_
11	dependency	dependency	NN	NN	_	7	dobj	_	_
12	as	as	IN	IN	_	13	case	_	_
13	that	that	WDT	WDT	_	11	nmod	_	_
14	observed	observe	VBN	VBN	_	13	acl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	8	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	TR75	tr75	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	evident	evident	JJ	JJ	_	0	root	_	_
9	during	during	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	peak	peak	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	infection	infection	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HL-60	hl-60	NN	NN	_	19	compound	_	_
19	promyelocytes	promyelocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	TR55	tr55	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	unaltered	unaltered	JJ	JJ	_	15	advcl	_	_
6	during	during	IN	IN	_	9	case	_	_
7	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	9	amod	_	_
8	HIV	hiv	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	15	punct	_	_
11	this	this	DT	DT	_	12	det	_	_
12	receptor	receptor	NN	NN	_	15	nsubjpass	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	still	still	RB	RB	_	15	advmod	_	_
15	involved	involve	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	viral	viral	JJ	JJ	_	20	amod	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	process	process	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	Antibody	antibody	NN	NN	_	2	compound	_	_
2	cross-linking	cross-linking	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TR55	tr55	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	dep	_	_
8	absence	absence	NN	NN	_	11	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	exogenous	exogenous	JJ	JJ	_	11	amod	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	13	nmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	induced	induce	VBN	VBN	_	0	root	_	_
14	maximal	maximal	JJ	JJ	_	16	amod	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	an	a	DT	DT	_	19	det	_	_
19	up-modulation	up-modulation	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	surface	surface	NN	NN	_	22	compound	_	_
22	TR75	tr75	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
26	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	16	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	OM-10.1	om-10.1	NN	NN	_	31	compound	_	_
31	cultures	culture	NNS	NNS	_	16	nmod	_	_
32	.	.	.	.	_	13	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	this	this	DT	DT	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	the	the	DT	DT	_	6	det	_	_
6	case	case	NN	NN	_	0	root	_	_
7	even	even	RB	RB	_	8	advmod	_	_
8	when	when	WRB	WRB	_	14	advmod	_	_
9	an	a	DT	DT	_	12	det	_	_
10	antagonistic	antagonistic	JJ	JJ	_	12	amod	_	_
11	anti-TR55	anti-tr55	JJ	JJ	_	12	amod	_	_
12	antibody	antibody	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	6	advcl	_	_
15	.	.	.	.	_	6	punct	_	_

1	Anti-TR55	anti-tr55	JJ	JJ	_	3	amod	_	_
2	antibody	antibody	NN	NN	_	3	compound	_	_
3	cross-linking	cross-linking	NN	NN	_	13	nsubj	_	_
4	in	in	IN	IN	_	9	case	_	_
5	chronically	chronically	RB	RB	_	6	advmod	_	_
6	infected	infected	JJ	JJ	_	9	amod	_	_
7	U1	u1	NN	NN	_	9	compound	_	_
8	promonocytic	promonocytic	JJ	JJ	_	9	amod	_	_
9	cultures	culture	NNS	NNS	_	3	nmod	_	_
10	could	could	MD	MD	_	13	aux	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	partially	partially	RB	RB	_	13	advmod	_	_
13	substitute	substitute	VB	VB	_	0	root	_	_
14	for	for	IN	IN	_	17	case	_	_
15	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	17	amod	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	5	dep	_	_
2	:	:	:	:	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	11	nsubj	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	selectively	selectively	RB	RB	_	11	advmod	_	_
11	influence	influence	VB	VB	_	5	ccomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	TNF	tnf	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	potentially	potentially	RB	RB	_	20	advmod	_	_
20	influencing	influence	VBG	VBG	_	11	dep	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	own	own	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	altering	alter	VBG	VBG	_	20	conj	_	_
26	normal	normal	JJ	JJ	_	29	amod	_	_
27	immunoregulatory	immunoregulatory	JJ	JJ	_	29	amod	_	_
28	signal	signal	NN	NN	_	29	compound	_	_
29	transduction	transduction	NN	NN	_	25	dobj	_	_
30	.	.	.	.	_	5	punct	_	_

1	FK506	fk506	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	ciclosporin	ciclosporin	NN	NN	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	probes	probe	NNS	NNS	_	1	dep	_	_
7	for	for	IN	IN	_	8	mark	_	_
8	studying	study	VBG	VBG	_	6	acl	_	_
9	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	immunosuppressants	immunosuppressant	NNS	NNS	_	6	nsubj	_	_
3	ciclosporin	ciclosporin	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	FK506	fk506	NN	NN	_	3	conj	_	_
6	block	block	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	Ca(2+)-dependent	ca(2+)-dependent	JJ	JJ	_	10	amod	_	_
9	signal-transduction	signal-transduction	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	6	dobj	_	_
11	emanating	emanate	VBG	VBG	_	10	acl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	thereby	thereby	RB	RB	_	18	advmod	_	_
18	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activation	activation	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	helper	helper	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	these	these	DT	DT	_	3	det	_	_
3	drugs	drug	NNS	NNS	_	1	dobj	_	_
4	as	as	IN	IN	_	5	case	_	_
5	probes	probe	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	chemists	chemist	NNS	NNS	_	11	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	biologists	biologist	NNS	NNS	_	7	conj	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	uncovered	uncover	VBN	VBN	_	0	root	_	_
12	several	several	JJ	JJ	_	15	amod	_	_
13	intracellular	intracellular	JJ	JJ	_	15	amod	_	_
14	signalling	signalling	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	11	dobj	_	_
16	bridging	bridge	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	generation	generation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	second-messenger	second-messenger	NN	NN	_	22	compound	_	_
21	Ca2+	ca2+	NN	NN	_	22	compound	_	_
22	ions	ion	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	18	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	15	punct	_	_
30	among	among	IN	IN	_	31	case	_	_
31	which	which	WDT	WDT	_	32	dep	_	_
32	are	be	VBP	VBP	_	15	acl:relcl	_	_
33	calmodulin	calmodulin	NN	NN	_	32	nsubj	_	_
34	,	,	,	,	_	33	punct	_	_
35	calcineurin	calcineurin	NN	NN	_	33	conj	_	_
36	and	and	CC	CC	_	33	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
39	factor	factor	NN	NN	_	33	conj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	activated	activate	VBN	VBN	_	43	amod	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	nmod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	NF-AT	nf-at	NN	NN	_	39	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	.	.	.	.	_	11	punct	_	_

1	Hence	hence	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Ca2+	ca2+	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	calmodulin	calmodulin	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	leading	lead	VBG	VBG	_	4	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	binding	binding	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	calmodulin	calmodulin	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	calcineurin	calcineurin	NN	NN	_	11	nmod	_	_
16	;	;	:	:	_	4	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	calcineurin	calcineurin	NN	NN	_	25	nsubj	_	_
20	,	,	,	,	_	25	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	turn	turn	NN	NN	_	25	nmod	_	_
23	,	,	,	,	_	25	punct	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	dephosphorylate	dephosphorylate	VB	VB	_	4	parataxis	_	_
26	the	the	DT	DT	_	28	det	_	_
27	cytoplasmic	cytoplasmic	JJ	JJ	_	28	amod	_	_
28	subunit	subunit	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	NF-AT	nf-at	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	25	punct	_	_
32	resulting	result	VBG	VBG	_	25	advcl	_	_
33	in	in	IN	IN	_	35	case	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	translocation	translocation	NN	NN	_	32	nmod	_	_
36	from	from	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	cytoplasm	cytoplasm	NN	NN	_	35	nmod	_	_
39	into	into	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	nucleus	nucleus	NN	NN	_	35	nmod	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	form	form	VB	VB	_	35	acl	_	_
44	a	a	DT	DT	_	47	det	_	_
45	competent	competent	JJ	JJ	_	47	amod	_	_
46	transcriptional	transcriptional	JJ	JJ	_	47	amod	_	_
47	activator	activator	NN	NN	_	43	dobj	_	_
48	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	described	describe	VBN	VBN	_	9	advcl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	Jun	Jun	NNP	NNP	_	5	compound	_	_
5	Liu	Liu	NNP	NNP	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	these	these	DT	DT	_	8	det	_	_
8	drugs	drug	NNS	NNS	_	9	nsubj	_	_
9	manifest	manifest	VBP	VBP	_	0	root	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	unprecedented	unprecedented	JJ	JJ	_	15	amod	_	_
15	fashion	fashion	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	They	they	PRP	PRP	_	5	nsubj	_	_
2	do	do	VBP	VBP	_	5	aux	_	_
3	not	not	RB	RB	_	5	neg	_	_
4	directly	directly	RB	RB	_	5	advmod	_	_
5	intercept	intercept	VB	VB	_	0	root	_	_
6	intracellular	intracellular	JJ	JJ	_	8	amod	_	_
7	signalling	signalling	NN	NN	_	8	compound	_	_
8	molecules	molecule	NNS	NNS	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Instead	instead	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	they	they	PRP	PRP	_	4	nsubj	_	_
4	form	form	VBP	VBP	_	0	root	_	_
5	tight	tight	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	4	dobj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	different	different	JJ	JJ	_	10	amod	_	_
10	classes	class	NNS	NNS	_	4	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	abundant	abundant	JJ	JJ	_	14	amod	_	_
13	cytosolic	cytosolic	JJ	JJ	_	14	amod	_	_
14	receptors	receptor	NNS	NNS	_	10	nmod	_	_
15	called	call	VBN	VBN	_	14	acl	_	_
16	immunophilins	immunophilin	NNS	NNS	_	15	xcomp	_	_
17	upon	upon	IN	IN	_	18	mark	_	_
18	entering	enter	VBG	VBG	_	4	advcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cell	cell	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	4	punct	_	_
22	and	and	CC	CC	_	4	cc	_	_
23	consequently	consequently	RB	RB	_	24	advmod	_	_
24	inhibit	inhibit	VBP	VBP	_	4	conj	_	_
25	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
26	peptidyl	peptidyl	JJ	JJ	_	30	amod	_	_
27	prolyl	prolyl	JJ	JJ	_	30	amod	_	_
28	cis-trans	cis-trans	JJ	JJ	_	30	amod	_	_
29	isomerase	isomerase	NN	NN	_	30	compound	_	_
30	activities	activity	NNS	NNS	_	24	dobj	_	_
31	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	structurally	structurally	RB	RB	_	4	advmod	_	_
4	distinct	distinct	JJ	JJ	_	6	amod	_	_
5	immunophilin-drug	immunophilin-drug	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	0	root	_	_
8	to	to	TO	TO	_	7	nmod	_	_
9	,	,	,	,	_	7	punct	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	inhibit	inhibit	VBP	VBP	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	phosphatase	phosphatase	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	7	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	calcineurin	calcineurin	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	impaired	impaired	JJ	JJ	_	8	amod	_	_
3	transcription	transcription	NN	NN	_	8	compound	_	_
4	factor	factor	NN	NN	_	8	compound	_	_
5	AP-1	ap-1	NN	NN	_	8	compound	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
11	derived	derive	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	13	case	_	_
13	subjects	subject	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	some	some	DT	DT	_	16	det	_	_
16	symptoms	symptom	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	premature	premature	JJ	JJ	_	19	amod	_	_
19	aging	aging	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	disorders	disorder	NNS	NNS	_	2	nmod	_	_
6	known	know	VBN	VBN	_	5	acl	_	_
7	as	as	IN	IN	_	10	case	_	_
8	premature	premature	JJ	JJ	_	10	amod	_	_
9	aging	aging	NN	NN	_	10	compound	_	_
10	syndromes	syndrome	NNS	NNS	_	6	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	provide	provide	VB	VB	_	0	root	_	_
13	insight	insight	NN	NN	_	12	dobj	_	_
14	into	into	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mechanisms	mechanism	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	senescence	senescence	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	main	main	JJ	JJ	_	3	amod	_	_
3	feature	feature	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	senescence	senescence	NN	NN	_	3	nmod	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	6	advmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	cessation	cessation	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	Down	down	NN	NN	_	2	compound	_	_
2	syndrome	syndrome	NN	NN	_	14	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	DS	ds	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	neuronal	neuronal	JJ	JJ	_	8	amod	_	_
8	ceroid-lypofuscinosis	ceroid-lypofuscinosis	NN	NN	_	2	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	NCL	ncl	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	14	auxpass	_	_
13	clinically	clinically	RB	RB	_	14	advmod	_	_
14	characterized	characterize	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	premature	premature	JJ	JJ	_	18	amod	_	_
18	onset	onset	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	numerous	numerous	JJ	JJ	_	21	amod	_	_
21	features	feature	NNS	NNS	_	18	nmod	_	_
22	normally	normally	RB	RB	_	23	advmod	_	_
23	associated	associate	VBN	VBN	_	21	acl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	aging	aging	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	Phytohemagglutinin	phytohemagglutinin	NN	NN	_	2	nmod:npmod	_	_
2	stimulated	stimulated	JJ	JJ	_	3	amod	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
4	derived	derive	VBN	VBN	_	3	acl	_	_
5	from	from	IN	IN	_	7	case	_	_
6	DS	ds	NN	NN	_	7	compound	_	_
7	subjects	subject	NNS	NNS	_	4	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	14	det	_	_
10	statistically	statistically	RB	RB	_	11	advmod	_	_
11	significant	significant	JJ	JJ	_	14	amod	_	_
12	diminished	diminish	VBN	VBN	_	14	amod	_	_
13	proliferation	proliferation	NN	NN	_	14	compound	_	_
14	capacity	capacity	NN	NN	_	8	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	comparison	comparison	NN	NN	_	18	dep	_	_
17	with	with	IN	IN	_	18	case	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
19	derived	derive	VBN	VBN	_	18	acl	_	_
20	from	from	IN	IN	_	24	case	_	_
21	NCL	ncl	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	healthy	healthy	JJ	JJ	_	21	conj	_	_
24	individuals	individual	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	by	by	IN	IN	_	5	mark	_	_
5	applying	apply	VBG	VBG	_	2	advcl	_	_
6	the	the	DT	DT	_	10	det	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	5	dobj	_	_
11	,	,	,	,	_	2	punct	_	_
12	slightly	slightly	RB	RB	_	13	advmod	_	_
13	impaired	impaired	JJ	JJ	_	17	amod	_	_
14	AP-1	ap-1	NN	NN	_	17	compound	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	2	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	NCL	ncl	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	strong	strong	JJ	JJ	_	17	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	DS	ds	NN	NN	_	25	compound	_	_
25	ones	one	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	same	same	JJ	JJ	_	8	amod	_	_
7	molecular	molecular	JJ	JJ	_	8	amod	_	_
8	mechanisms	mechanism	NNS	NNS	_	13	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	proliferation	proliferation	NN	NN	_	11	compound	_	_
11	cessation	cessation	NN	NN	_	8	nmod	_	_
12	could	could	MD	MD	_	13	aux	_	_
13	exist	exist	VB	VB	_	3	ccomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	fibroblasts	fibroblast	NNS	NNS	_	13	nmod	_	_
16	characterized	characterize	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	replicative	replicative	JJ	JJ	_	19	amod	_	_
19	senescence	senescence	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	in	in	IN	IN	_	22	case	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
23	derived	derive	VBN	VBN	_	22	acl	_	_
24	from	from	IN	IN	_	25	case	_	_
25	individuals	individual	NNS	NNS	_	23	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	premature	premature	JJ	JJ	_	29	amod	_	_
28	aging	aging	NN	NN	_	29	compound	_	_
29	syndromes	syndrome	NNS	NNS	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	Down	down	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
4	latency	latency	NN	NN	_	5	compound	_	_
5	reactivation	reactivation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	DHEA	dhea	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	an	a	DT	DT	_	13	det	_	_
13	analog	analog	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	DHEA	dhea	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	initial	initial	JJ	JJ	_	3	amod	_	_
3	infection	infection	NN	NN	_	17	nsubj	_	_
4	with	with	IN	IN	_	8	case	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	3	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HIV-1	hiv-1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	15	case	_	_
14	most	most	JJS	JJS	_	15	amod	_	_
15	individuals	individual	NNS	NNS	_	3	nmod	_	_
16	usually	usually	RB	RB	_	17	advmod	_	_
17	results	result	VBZ	VBZ	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	establishment	establishment	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	latent	latent	JJ	JJ	_	26	amod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	chronic	chronic	JJ	JJ	_	23	conj	_	_
26	infection	infection	NN	NN	_	20	nmod	_	_
27	before	before	IN	IN	_	29	case	_	_
28	eventual	eventual	JJ	JJ	_	29	amod	_	_
29	progression	progression	NN	NN	_	20	nmod	_	_
30	toward	toward	IN	IN	_	33	case	_	_
31	acquired	acquire	VBN	VBN	_	33	amod	_	_
32	immunodeficiency	immunodeficiency	NN	NN	_	33	compound	_	_
33	syndrome	syndrome	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	4	nsubj	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	establish	establish	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	latent	latent	JJ	JJ	_	9	amod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	persistent	persistent	JJ	JJ	_	6	conj	_	_
9	infection	infection	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	some	some	DT	DT	_	14	det	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	4	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	show	show	VBP	VBP	_	14	acl:relcl	_	_
17	minimal	minimal	JJ	JJ	_	20	amod	_	_
18	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	activation	activation	NN	NN	_	16	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	3	nmod	_	_
9	leading	lead	VBG	VBG	_	3	acl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	enhanced	enhance	VBN	VBN	_	13	amod	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	9	nmod	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	antigens	antigen	NNS	NNS	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	mitogens	mitogen	NNS	NNS	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	cytokines	cytokine	NNS	NNS	_	18	conj	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	tumor	tumor	NN	NN	_	28	compound	_	_
26	necrosis	necrosis	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	18	dep	_	_
29	-LSB-	-lsb-	-LRB-	-LRB-	_	30	punct	_	_
30	TNF-alpha	tnf-alpha	NN	NN	_	28	appos	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	28	punct	_	_
33	interleukin	interleukin	NN	NN	_	28	conj	_	_
34	1	1	CD	CD	_	33	nummod	_	_
35	,	,	,	,	_	28	punct	_	_
36	and	and	CC	CC	_	28	cc	_	_
37	interleukin-2	interleukin-2	NN	NN	_	28	conj	_	_
38	)	)	-RRB-	-RRB-	_	28	punct	_	_
39	.	.	.	.	_	16	punct	_	_

1	Various	various	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	products	product	NNS	NNS	_	23	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	other	other	JJ	JJ	_	6	amod	_	_
6	viruses	virus	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-1	htlv-1	NN	NN	_	6	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	HSV	hsv	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	EBV	ebv	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	CMV	cmv	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	HBV	hbv	NN	NN	_	8	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	HHV-6	hhv-6	NN	NN	_	8	conj	_	_
20	)	)	-RRB-	-RRB-	_	8	punct	_	_
21	can	can	MD	MD	_	23	aux	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	enhance	enhance	VB	VB	_	0	root	_	_
24	HIV-1	hiv-1	NN	NN	_	34	compound	_	_
25	long	long	JJ	JJ	_	31	amod	_	_
26	terminal	terminal	JJ	JJ	_	31	amod	_	_
27	repeat	repeat	NN	NN	_	31	nmod:npmod	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	LTR	ltr	NN	NN	_	31	nmod:npmod	_	_
30	)	)	-RRB-	-RRB-	_	31	punct	_	_
31	-driven	-driven	JJ	JJ	_	34	amod	_	_
32	reporter	reporter	NN	NN	_	34	compound	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	activity	activity	NN	NN	_	23	dobj	_	_
35	.	.	.	.	_	23	punct	_	_

1	On	on	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	dep	_	_
3	basis	basis	NN	NN	_	6	dep	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	observations	observation	NNS	NNS	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	it	it	PRP	PRP	_	11	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	proposed	propose	VBN	VBN	_	0	root	_	_
12	that	that	IN	IN	_	28	mark	_	_
13	reactivation	reactivation	NN	NN	_	28	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	latent	latent	JJ	JJ	_	16	amod	_	_
16	HIV-1	hiv-1	NN	NN	_	13	nmod	_	_
17	harbored	harbor	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	22	case	_	_
19	chronically	chronically	RB	RB	_	20	advmod	_	_
20	infected	infected	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	monocytes	monocyte	NNS	NNS	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	or	or	CC	CC	_	22	cc	_	_
27	macrophages	macrophage	NNS	NNS	_	22	conj	_	_
28	plays	play	VBZ	VBZ	_	11	ccomp	_	_
29	an	a	DT	DT	_	31	det	_	_
30	important	important	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	pathogenesis	pathogenesis	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	AIDS	aids	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	So	so	RB	RB	_	2	advmod	_	_
2	far	far	RB	RB	_	5	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	are	be	VBP	VBP	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	drugs	drug	NNS	NNS	_	5	nsubj	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	therapy	therapy	NN	NN	_	7	conj	_	_
10	available	available	JJ	JJ	_	7	amod	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	provide	provide	VB	VB	_	7	acl:relcl	_	_
14	protection	protection	NN	NN	_	13	dobj	_	_
15	against	against	IN	IN	_	18	case	_	_
16	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
17	latency	latency	NN	NN	_	18	compound	_	_
18	reactivation	reactivation	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	ACH-2	ach-2	NN	NN	_	16	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	derived	derive	VBN	VBN	_	1	acl	_	_
4	from	from	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CEM	cem	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	1	punct	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	chronically	chronically	RB	RB	_	16	advmod	_	_
16	infected	infect	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	18	case	_	_
18	HIV-1	hiv-1	NN	NN	_	16	advcl	_	_
19	,	,	,	,	_	16	punct	_	_
20	with	with	IN	IN	_	22	case	_	_
21	low	low	JJ	JJ	_	22	amod	_	_
22	levels	level	NNS	NNS	_	16	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	constitutive	constitutive	JJ	JJ	_	26	amod	_	_
25	virus	virus	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	ACH-2	ach-2	NN	NN	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	converted	convert	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	productive	productive	JJ	JJ	_	7	amod	_	_
7	infection	infection	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	stimulation	stimulation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TPA	tpa	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	mitogen	mitogen	NN	NN	_	14	conj	_	_
20	or	or	CC	CC	_	14	cc	_	_
21	cytokines	cytokine	NNS	NNS	_	14	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	7	punct	_	_
26	or	or	CC	CC	_	7	cc	_	_
27	infection	infection	NN	NN	_	7	conj	_	_
28	with	with	IN	IN	_	29	case	_	_
29	HSV	hsv	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Therefore	therefore	RB	RB	_	9	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	ACH-2	ach-2	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	good	good	JJ	JJ	_	9	amod	_	_
9	candidate	candidate	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	studying	study	VBG	VBG	_	9	acl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	drugs	drug	NNS	NNS	_	13	nmod	_	_
16	on	on	IN	IN	_	18	case	_	_
17	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Previously	previously	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	reported	report	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	DHEA	dhea	NN	NN	_	16	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	synthetic	synthetic	JJ	JJ	_	10	amod	_	_
10	analogs	analog	NNS	NNS	_	7	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	DHEA	dhea	NN	NN	_	10	nmod	_	_
13	can	can	MD	MD	_	16	aux	_	_
14	be	be	VB	VB	_	16	cop	_	_
15	modest	modest	JJ	JJ	_	16	amod	_	_
16	inhibitors	inhibitor	NNS	NNS	_	5	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
19	IIIB	iiib	NN	NN	_	20	compound	_	_
20	replication	replication	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	26	case	_	_
22	phytohemagglutinin-stimulated	phytohemagglutinin-stimulated	JJ	JJ	_	26	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	lymphocyte	lymphocyte	NN	NN	_	26	compound	_	_
26	cultures	culture	NNS	NNS	_	16	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	immune	immune	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cytokine	cytokine	NN	NN	_	2	conj	_	_
5	pathways	pathway	NNS	NNS	_	0	root	_	_
6	resulting	result	VBG	VBG	_	5	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	tissue	tissue	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	relevance	relevance	NN	NN	_	10	conj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	septic	septic	JJ	JJ	_	15	amod	_	_
15	shock	shock	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Cells	cell	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	monocyte	monocyte	NN	NN	_	4	compound	_	_
4	lineage	lineage	NN	NN	_	1	nmod	_	_
5	serve	serve	VBP	VBP	_	0	root	_	_
6	as	as	IN	IN	_	8	case	_	_
7	effector	effector	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	cellular	cellular	JJ	JJ	_	13	amod	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	response	response	NN	NN	_	5	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	they	they	PRP	PRP	_	5	nsubj	_	_
5	respond	respond	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	LPS	lps	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cytokines	cytokine	NNS	NNS	_	7	conj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	expression	expression	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
16	effector	effector	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	products	product	NNS	NNS	_	11	nmod	_	_
19	similar	similar	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	those	those	DT	DT	_	19	nmod	_	_
22	elicited	elicit	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	antigen	antigen	NN	NN	_	26	nmod:npmod	_	_
26	driven	driven	JJ	JJ	_	27	amod	_	_
27	response	response	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	response	response	NN	NN	_	5	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	antigen	antigen	NN	NN	_	2	nmod	_	_
5	proceeds	proceed	VBZ	VBZ	_	0	root	_	_
6	at	at	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	helper	helper	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	level	level	NN	NN	_	5	nmod	_	_
12	through	through	IN	IN	_	15	case	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	independent	independent	JJ	JJ	_	15	amod	_	_
15	forms	form	NNS	NNS	_	5	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	collaboration	collaboration	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	contact	contact	NN	NN	_	15	appos	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	lymphokine	lymphokine	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	review	review	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	control	control	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	expression	expression	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	Tissue	tissue	NN	NN	_	10	compound	_	_
10	Factor	factor	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TF	tf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	gene	gene	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	function	function	NN	NN	_	4	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	TF	tf	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	enhanced	enhance	VBN	VBN	_	3	amod	_	_
3	initiation	initiation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	transcription	transcription	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	TF	tf	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	appears	appear	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	require	require	VB	VB	_	10	xcomp	_	_
13	engagement	engagement	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	a	a	DT	DT	_	20	det	_	_
16	56	56	CD	CD	_	17	compound	_	_
17	bp	bp	NN	NN	_	20	amod	_	_
18	LPS	lps	NN	NN	_	20	compound	_	_
19	Response	response	NN	NN	_	20	compound	_	_
20	Element	element	NN	NN	_	13	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	an	a	DT	DT	_	23	det	_	_
23	enhancer	enhancer	NN	NN	_	20	appos	_	_
24	that	that	WDT	WDT	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	engaged	engage	VBN	VBN	_	23	acl:relcl	_	_
27	by	by	IN	IN	_	32	case	_	_
28	both	both	DT	DT	_	32	dep	_	_
29	AP-1	ap-1	NN	NN	_	32	compound	_	_
30	type	type	NN	NN	_	32	compound	_	_
31	heterodimeric	heterodimeric	JJ	JJ	_	32	amod	_	_
32	complexes	complex	NNS	NNS	_	26	nmod	_	_
33	as	as	RB	RB	_	32	cc	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	as	as	IN	IN	_	33	mwe	_	_
36	NF	nf	NN	NN	_	38	compound	_	_
37	kappa	kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	39	nmod:npmod	_	_
39	like	like	IN	IN	_	41	amod	_	_
40	heterodimeric	heterodimeric	JJ	JJ	_	41	amod	_	_
41	complexes	complex	NNS	NNS	_	32	conj	_	_
42	.	.	.	.	_	10	punct	_	_

1	Dissociation	dissociation	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF	nf	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	from	from	IN	IN	_	9	case	_	_
7	Ig	ig	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	14	case	_	_
11	cytokine	cytokine	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	LPS	lps	NN	NN	_	11	conj	_	_
14	stimulation	stimulation	NN	NN	_	1	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	possibly	possibly	RB	RB	_	20	advmod	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	represent	represent	VB	VB	_	0	root	_	_
24	a	a	DT	DT	_	26	det	_	_
25	common	common	JJ	JJ	_	26	amod	_	_
26	pathway	pathway	NN	NN	_	23	dobj	_	_
27	to	to	TO	TO	_	28	case	_	_
28	induction	induction	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	TF	tf	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	other	other	JJ	JJ	_	34	amod	_	_
34	inflammatory	inflammatory	JJ	JJ	_	31	conj	_	_
35	genes	gene	NNS	NNS	_	31	dep	_	_
36	.	.	.	.	_	23	punct	_	_

1	Enhancement	enhancement	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	expression	expression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	TF	tf	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	upon	upon	IN	IN	_	9	case	_	_
9	adhesion	adhesion	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Mo	mo	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	endothelial	endothelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	extracellular	extracellular	JJ	JJ	_	18	amod	_	_
17	matrix	matrix	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	14	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	as	as	RB	RB	_	9	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	upon	upon	IN	IN	_	24	case	_	_
24	engagement	engagement	NN	NN	_	9	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	leukocyte	leukocyte	NN	NN	_	27	compound	_	_
27	integrins	integrin	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biological	biological	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	15	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	follow	follow	VBP	VBP	_	3	acl:relcl	_	_
6	from	from	IN	IN	_	7	case	_	_
7	expression	expression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TF	tf	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	vascular	vascular	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	resolved	resolve	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	analysis	analysis	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	function	function	NN	NN	_	17	nmod	_	_
20	aided	aid	VBN	VBN	_	17	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	use	use	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	recombinant	recombinant	JJ	JJ	_	28	amod	_	_
26	full	full	JJ	JJ	_	28	amod	_	_
27	length	length	NN	NN	_	28	compound	_	_
28	TF	tf	NN	NN	_	23	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	truncated	truncate	VBN	VBN	_	32	amod	_	_
31	surface	surface	NN	NN	_	32	compound	_	_
32	domain	domain	NN	NN	_	28	conj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	TF	tf	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rules	rule	NNS	NNS	_	53	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	assembly	assembly	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cognate	cognate	JJ	JJ	_	8	amod	_	_
8	ligands	ligand	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	TF	tf	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	namely	namely	RB	RB	_	8	advmod	_	_
13	the	the	DT	DT	_	17	det	_	_
14	zymogen	zymogen	NN	NN	_	17	compound	_	_
15	plasma	plasma	NN	NN	_	17	compound	_	_
16	factors	factor	NNS	NNS	_	17	compound	_	_
17	VII	vii	NN	NN	_	8	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	23	det	_	_
20	serine	serine	NN	NN	_	23	compound	_	_
21	protease	protease	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	VIIa	viia	NN	NN	_	17	conj	_	_
24	,	,	,	,	_	8	punct	_	_
25	with	with	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	soluble	soluble	JJ	JJ	_	29	amod	_	_
28	surface	surface	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	4	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	TF	tf	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	free	free	JJ	JJ	_	34	amod	_	_
34	solution	solution	NN	NN	_	29	nmod	_	_
35	,	,	,	,	_	2	punct	_	_
36	in	in	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	presence	presence	NN	NN	_	2	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	phospholipid	phospholipid	JJ	JJ	_	41	amod	_	_
41	surfaces	surface	NNS	NNS	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	surface	surface	NN	NN	_	41	conj	_	_
45	and	and	CC	CC	_	41	cc	_	_
46	of	of	IN	IN	_	50	case	_	_
47	the	the	DT	DT	_	50	det	_	_
48	anchored	anchor	VBN	VBN	_	50	amod	_	_
49	TF	tf	NN	NN	_	50	compound	_	_
50	molecule	molecule	NN	NN	_	41	conj	_	_
51	have	have	VBP	VBP	_	53	aux	_	_
52	been	be	VBN	VBN	_	53	auxpass	_	_
53	described	describe	VBN	VBN	_	0	root	_	_
54	.	.	.	.	_	53	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	evident	evident	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	assembly	assembly	NN	NN	_	20	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	surface	surface	NN	NN	_	9	compound	_	_
9	domain	domain	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TF	tf	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	VIIa	viia	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	form	form	VB	VB	_	5	acl	_	_
16	the	the	DT	DT	_	19	det	_	_
17	binary	binary	JJ	JJ	_	19	amod	_	_
18	TF.VIIa	tf.viia	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	15	dobj	_	_
20	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	significant	significant	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	Kcat	kcat	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	catalytic	catalytic	JJ	JJ	_	30	amod	_	_
30	domain	domain	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	VIIa	viia	NN	NN	_	30	nmod	_	_
33	for	for	IN	IN	_	36	case	_	_
34	small	small	JJ	JJ	_	36	amod	_	_
35	peptidyl	peptidyl	JJ	JJ	_	36	amod	_	_
36	substrates	substrate	NNS	NNS	_	30	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	more	more	JJR	JJR	_	39	dep	_	_
39	profoundly	profoundly	RB	RB	_	42	advmod	_	_
40	for	for	IN	IN	_	42	case	_	_
41	protein	protein	NN	NN	_	42	compound	_	_
42	substrate	substrate	NN	NN	_	36	conj	_	_
43	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	provides	provide	VBZ	VBZ	_	0	root	_	_
3	substantial	substantial	JJ	JJ	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	allosteric	allosteric	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	4	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	catalytic	catalytic	JJ	JJ	_	12	amod	_	_
12	cleft	cleft	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	VIIa	viia	NN	NN	_	12	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	imparted	impart	VBN	VBN	_	14	acl:relcl	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	binding	bind	VBG	VBG	_	17	advcl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	TF	tf	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
24	cognate	cognate	JJ	JJ	_	26	amod	_	_
25	catalytic	catalytic	JJ	JJ	_	26	amod	_	_
26	cofactor	cofactor	NN	NN	_	21	appos	_	_
27	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	evident	evident	JJ	JJ	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TF.VIIa	tf.viia	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	proteolytically	proteolytically	RB	RB	_	11	advmod	_	_
11	active	active	JJ	JJ	_	4	ccomp	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	activate	activate	VB	VB	_	11	conj	_	_
15	the	the	DT	DT	_	19	det	_	_
16	zymogen	zymogen	NN	NN	_	19	compound	_	_
17	plasma	plasma	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	X	x	NN	NN	_	14	dobj	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	serine	serine	NN	NN	_	24	compound	_	_
23	protease	protease	NN	NN	_	24	compound	_	_
24	Xa	xa	NN	NN	_	14	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	free	free	JJ	JJ	_	27	amod	_	_
27	solution	solution	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	4	punct	_	_
29	inferring	infer	VBG	VBG	_	4	xcomp	_	_
30	that	that	IN	IN	_	43	mark	_	_
31	extended	extend	VBN	VBN	_	33	amod	_	_
32	substrate	substrate	NN	NN	_	33	compound	_	_
33	recognition	recognition	NN	NN	_	43	nsubjpass	_	_
34	by	by	IN	IN	_	37	case	_	_
35	induced	induce	VBN	VBN	_	37	amod	_	_
36	structural	structural	JJ	JJ	_	37	amod	_	_
37	loci	locus	NNS	NNS	_	33	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	TF.VIIa	tf.viia	NN	NN	_	41	compound	_	_
41	complex	complex	NN	NN	_	37	nmod	_	_
42	are	be	VBP	VBP	_	43	auxpass	_	_
43	created	create	VBN	VBN	_	29	ccomp	_	_
44	from	from	IN	IN	_	45	case	_	_
45	either	either	DT	DT	_	43	nmod	_	_
46	or	or	CC	CC	_	45	cc	_	_
47	both	both	DT	DT	_	45	conj	_	_
48	proteins	protein	NNS	NNS	_	45	dep	_	_
49	to	to	TO	TO	_	50	mark	_	_
50	constitute	constitute	VB	VB	_	43	xcomp	_	_
51	a	a	DT	DT	_	54	det	_	_
52	new	new	JJ	JJ	_	54	amod	_	_
53	recognition	recognition	NN	NN	_	54	compound	_	_
54	structure	structure	NN	NN	_	50	dobj	_	_
55	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	evident	evident	JJ	JJ	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	association	association	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	X	x	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	charged	charged	JJ	JJ	_	12	amod	_	_
11	phospholipid	phospholipid	JJ	JJ	_	12	amod	_	_
12	surfaces	surface	NNS	NNS	_	6	nmod	_	_
13	enhances	enhance	VBZ	VBZ	_	4	ccomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	proteolytic	proteolytic	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	zymogen	zymogen	NN	NN	_	16	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	increasing	increase	VBG	VBG	_	13	advcl	_	_
22	recognition	recognition	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	susceptibility	susceptibility	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	sessile	sessile	NN	NN	_	29	compound	_	_
28	peptide	peptide	NN	NN	_	29	compound	_	_
29	bond	bond	NN	NN	_	22	nmod	_	_
30	deduced	deduce	VBN	VBN	_	29	acl	_	_
31	from	from	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	markedly	markedly	RB	RB	_	35	advmod	_	_
34	decreased	decrease	VBN	VBN	_	35	amod	_	_
35	Km	km	NN	NN	_	30	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	increased	increase	VBN	VBN	_	38	amod	_	_
38	Kcat	kcat	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	4	punct	_	_

1	Visualization	visualization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	endogenous	endogenous	JJ	JJ	_	8	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	p50	p50	NN	NN	_	8	compound	_	_
8	subunit	subunit	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	nucleus	nucleus	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	follicular	follicular	JJ	JJ	_	15	amod	_	_
14	dendritic	dendritic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	germinal	germinal	JJ	JJ	_	18	amod	_	_
18	centers	center	NNS	NNS	_	1	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	11	det	_	_
5	50	50	CD	CD	_	7	compound	_	_
6	kDa/65	kda/65	CD	CD	_	7	compound	_	_
7	kDa	kda	NN	NN	_	11	amod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	p50/p65	p50/p65	NN	NN	_	7	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	heterodimer	heterodimer	NN	NN	_	2	appos	_	_
12	,	,	,	,	_	2	punct	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	a	a	DT	DT	_	17	det	_	_
15	ubiquitous	ubiquitous	JJ	JJ	_	17	amod	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	0	root	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	positive	positive	JJ	JJ	_	22	amod	_	_
22	regulation	regulation	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	various	various	JJ	JJ	_	26	amod	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	13	mark	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	related	related	JJ	JJ	_	8	ccomp	_	_
14	to	to	TO	TO	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	particular	particular	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	type	type	NN	NN	_	13	nmod	_	_
19	and/or	and/or	CC	CC	_	18	cc	_	_
20	differentiation	differentiation	NN	NN	_	21	compound	_	_
21	step	step	NN	NN	_	18	conj	_	_
22	during	during	IN	IN	_	23	case	_	_
23	immunopoiesis	immunopoiesis	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	15	advcl	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	situ	situ	FW	FW	_	2	dep	_	_
4	hybridization	hybridization	NN	NN	_	1	dobj	_	_
5	on	on	IN	IN	_	6	case	_	_
6	sections	section	NNS	NNS	_	1	nmod	_	_
7	from	from	IN	IN	_	12	case	_	_
8	non	non	JJ	JJ	_	9	dep	_	_
9	HIV	hiv	NN	NN	_	12	amod	_	_
10	hyperplastic	hyperplastic	JJ	JJ	_	12	amod	_	_
11	lymph	lymph	NN	NN	_	12	compound	_	_
12	nodes	node	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	found	find	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	27	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	gene	gene	NN	NN	_	27	nsubjpass	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	105	105	CD	CD	_	22	compound	_	_
22	kDa	kda	NN	NN	_	23	amod	_	_
23	precursor	precursor	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	p50	p50	NN	NN	_	23	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	overexpressed	overexpress	VBN	VBN	_	15	ccomp	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	light	light	JJ	JJ	_	31	amod	_	_
31	zone	zone	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	germinal	germinal	JJ	JJ	_	34	amod	_	_
34	centers	center	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	27	punct	_	_
36	with	with	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	network	network	NN	NN	_	39	compound	_	_
39	aspect	aspect	NN	NN	_	27	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	which	which	WDT	WDT	_	42	nsubj	_	_
42	suggested	suggest	VBD	VBD	_	39	acl:relcl	_	_
43	the	the	DT	DT	_	44	det	_	_
44	involvement	involvement	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	48	case	_	_
46	follicular	follicular	JJ	JJ	_	48	amod	_	_
47	dendritic	dendritic	JJ	JJ	_	48	amod	_	_
48	cells	cell	NNS	NNS	_	44	nmod	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	FDC	fdc	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	15	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	immunohistochemistry	immunohistochemistry	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	p50	p50	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cytoplasm	cytoplasm	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	nucleus	nucleus	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	FDC	fdc	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	confirming	confirm	VBG	VBG	_	7	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	involvement	involvement	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	FDC	fdc	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	p50	p50	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cytoplasm	cytoplasm	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	all	all	DT	DT	_	12	det	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	focused	focus	VBD	VBD	_	0	root	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	study	study	NN	NN	_	4	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	isolated	isolate	VBN	VBN	_	10	amod	_	_
9	FDC	fdc	NN	NN	_	10	compound	_	_
10	clusters	cluster	NNS	NNS	_	4	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	tonsils	tonsil	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	showed	show	VBN	VBN	_	8	advcl	_	_
3	on	on	IN	IN	_	5	case	_	_
4	tissue	tissue	NN	NN	_	5	compound	_	_
5	sections	section	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	detected	detect	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	p50	p50	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	cytoplasm	cytoplasm	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nucleus	nucleus	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	FDC	fdc	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Nuclei	nucleus	NNS	NNS	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
4	from	from	IN	IN	_	6	case	_	_
5	FDC	fdc	NN	NN	_	6	compound	_	_
6	clusters	cluster	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	negative	negative	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	next	next	RB	RB	_	3	advmod	_	_
3	studied	study	VBD	VBD	_	0	root	_	_
4	p65	p65	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	c-Rel	c-rel	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	4	conj	_	_
8	expression	expression	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	FDC	fdc	NN	NN	_	11	compound	_	_
11	clusters	cluster	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	p65	p65	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	detected	detect	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cytoplasm	cytoplasm	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	FDC	fdc	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	whereas	whereas	IN	IN	_	3	dep	_	_
11	nuclei	nucleus	NNS	NNS	_	13	nsubj	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	negative	negative	JJ	JJ	_	3	parataxis	_	_
14	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	p65	p65	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nuclei	nucleus	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	some	some	DT	DT	_	11	det	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	c-Rel	c-rel	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	only	only	RB	RB	_	8	advmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cytoplasm	cytoplasm	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	8	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cytoplasm	cytoplasm	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	FDC	fdc	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	23	mark	_	_
5	,	,	,	,	_	23	punct	_	_
6	in	in	IN	IN	_	14	case	_	_
7	the	the	DT	DT	_	14	dep	_	_
8	context	context	NN	NN	_	14	dep	_	_
9	of	of	IN	IN	_	14	case	_	_
10	T	t	NN	NN	_	11	nmod:npmod	_	_
11	cell-dependent	cell-dependent	JJ	JJ	_	14	amod	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	immunopoiesis	immunopoiesis	NN	NN	_	23	nmod	_	_
15	occurring	occur	VBG	VBG	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	FDC	fdc	NN	NN	_	18	compound	_	_
18	clusters	cluster	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	p50	p50	NN	NN	_	23	nsubj	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	mainly	mainly	RB	RB	_	23	advmod	_	_
23	related	related	JJ	JJ	_	3	ccomp	_	_
24	to	to	TO	TO	_	25	case	_	_
25	FDC	fdc	NN	NN	_	23	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	massive	massive	JJ	JJ	_	29	amod	_	_
29	overexpression	overexpression	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	nuclei	nucleus	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	23	punct	_	_
34	whereas	whereas	IN	IN	_	23	dep	_	_
35	p65	p65	NN	NN	_	37	nsubjpass	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	expressed	express	VBN	VBN	_	23	parataxis	_	_
38	in	in	IN	IN	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	scattered	scatter	VBN	VBN	_	41	amod	_	_
41	manner	manner	NN	NN	_	37	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	nuclei	nucleus	NNS	NNS	_	37	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	lymphocytes	lymphocyte	NNS	NNS	_	44	nmod	_	_
47	and	and	CC	CC	_	37	cc	_	_
48	c-Rel	c-rel	NN	NN	_	49	compound	_	_
49	protein	protein	NN	NN	_	37	conj	_	_
50	exclusively	exclusively	RB	RB	_	49	advmod	_	_
51	in	in	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	cytoplasm	cytoplasm	NN	NN	_	49	dep	_	_
54	of	of	IN	IN	_	55	case	_	_
55	lymphocytes	lymphocyte	NNS	NNS	_	53	nmod	_	_
56	from	from	IN	IN	_	58	case	_	_
57	FDC	fdc	NN	NN	_	58	compound	_	_
58	clusters	cluster	NNS	NNS	_	55	nmod	_	_
59	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	subunits	subunit	NNS	NNS	_	15	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	c-Rel	c-rel	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	7	conj	_	_
15	have	have	VBP	VBP	_	3	ccomp	_	_
16	different	different	JJ	JJ	_	17	amod	_	_
17	roles	role	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	different	different	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	types	type	NNS	NNS	_	15	nmod	_	_
22	during	during	IN	IN	_	25	case	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	immunopoiesis	immunopoiesis	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	YB-1	yb-1	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	15	case	_	_
7	human	human	JJ	JJ	_	15	amod	_	_
8	T-cell	t-cell	NN	NN	_	15	compound	_	_
9	lymphotropic	lymphotropic	JJ	JJ	_	15	amod	_	_
10	virus	virus	NN	NN	_	15	compound	_	_
11	type	type	NN	NN	_	15	compound	_	_
12	I	i	CD	CD	_	15	nummod	_	_
13	basal	basal	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Sequences	sequence	NNS	NNS	_	16	nsubj	_	_
2	which	which	WDT	WDT	_	3	nsubj	_	_
3	control	control	VBP	VBP	_	1	acl:relcl	_	_
4	basal	basal	JJ	JJ	_	14	amod	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	T-cell	t-cell	NN	NN	_	9	compound	_	_
7	lymphotropic	lymphotropic	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	14	compound	_	_
10	I	i	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HTLV-I	htlv-i	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	transcription	transcription	NN	NN	_	3	dobj	_	_
15	likely	likely	RB	RB	_	16	advmod	_	_
16	play	play	VB	VB	_	0	root	_	_
17	an	a	DT	DT	_	19	det	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	initiation	initiation	NN	NN	_	16	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	maintenance	maintenance	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	virus	virus	NN	NN	_	26	compound	_	_
26	replication	replication	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	analyzed	analyze	VBD	VBD	_	3	conj	_	_
6	a	a	DT	DT	_	8	det	_	_
7	45-nucleotide	45-nucleotide	JJ	JJ	_	8	amod	_	_
8	sequence	sequence	NN	NN	_	3	dobj	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	downstream	downstream	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	8	dep	_	_
13	1	1	CD	CD	_	12	nummod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	DRE	dre	NN	NN	_	12	appos	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_
18	)	)	-RRB-	-RRB-	_	12	punct	_	_
19	,	,	,	,	_	8	punct	_	_
20	+195	+195	CD	CD	_	8	appos	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	+240	+240	CD	CD	_	20	dep	_	_
23	,	,	,	,	_	8	punct	_	_
24	at	at	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	boundary	boundary	NN	NN	_	8	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	R/U5	r/u5	NN	NN	_	30	compound	_	_
30	region	region	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	long	long	JJ	JJ	_	35	amod	_	_
34	terminal	terminal	JJ	JJ	_	35	amod	_	_
35	repeat	repeat	NN	NN	_	30	nmod	_	_
36	which	which	WDT	WDT	_	38	nsubjpass	_	_
37	is	be	VBZ	VBZ	_	38	auxpass	_	_
38	required	require	VBN	VBN	_	30	acl:relcl	_	_
39	for	for	IN	IN	_	42	case	_	_
40	HTLV-I	htlv-i	NN	NN	_	42	compound	_	_
41	basal	basal	JJ	JJ	_	42	amod	_	_
42	transcription	transcription	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	protein	protein	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	p37	p37	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	which	which	WDT	WDT	_	10	nsubj	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	bound	bind	VBD	VBD	_	4	acl:relcl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	DRE	dre	NN	NN	_	10	nmod	_	_
13	1	1	CD	CD	_	12	nummod	_	_
14	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	affinity	affinity	NN	NN	_	4	compound	_	_
3	column	column	NN	NN	_	4	compound	_	_
4	fraction	fraction	NN	NN	_	9	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	containing	contain	VBG	VBG	_	4	acl	_	_
7	p37	p37	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	4	punct	_	_
9	stimulated	stimulate	VBD	VBD	_	0	root	_	_
10	HTLV-I	htlv-i	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	12-fold	12-fold	RB	RB	_	9	advmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	9	advmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	identification	identification	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	cDNA	cdna	NN	NN	_	9	compound	_	_
9	clone	clone	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	15B-7	15b-7	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	from	from	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	Jurkat	jurkat	NN	NN	_	18	compound	_	_
17	expression	expression	NN	NN	_	18	compound	_	_
18	library	library	NN	NN	_	9	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	binds	bind	VBZ	VBZ	_	9	acl:relcl	_	_
22	specifically	specifically	RB	RB	_	21	advmod	_	_
23	to	to	TO	TO	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	DRE	dre	NN	NN	_	28	compound	_	_
26	1	1	CD	CD	_	28	nummod	_	_
27	regulatory	regulatory	JJ	JJ	_	28	amod	_	_
28	sequence	sequence	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	19	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	cDNA	cdna	NN	NN	_	6	compound	_	_
5	fusion	fusion	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	similarly	similarly	RB	RB	_	11	advmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	results	result	NNS	NNS	_	1	nmod	_	_
12	obtained	obtain	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	purified	purify	VBN	VBN	_	16	amod	_	_
15	Jurkat	jurkat	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	decreased	decrease	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	21	case	_	_
21	introduction	introduction	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	site-specific	site-specific	JJ	JJ	_	24	amod	_	_
24	mutations	mutation	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	DRE	dre	NN	NN	_	30	compound	_	_
28	1	1	CD	CD	_	30	nummod	_	_
29	regulatory	regulatory	JJ	JJ	_	30	amod	_	_
30	sequence	sequence	NN	NN	_	21	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	translation	translation	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	15B-7	15b-7	NN	NN	_	8	compound	_	_
8	cDNA	cdna	NN	NN	_	3	nmod	_	_
9	produced	produce	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	fusion	fusion	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	9	dobj	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	bound	bind	VBD	VBD	_	12	acl:relcl	_	_
15	specifically	specifically	RB	RB	_	14	advmod	_	_
16	to	to	TO	TO	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	HTLV-I	htlv-i	NN	NN	_	22	compound	_	_
19	+195	+195	CD	CD	_	22	compound	_	_
20	to	to	TO	TO	_	19	dep	_	_
21	+240	+240	CD	CD	_	19	dep	_	_
22	oligonucleotide	oligonucleotide	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	partial	partial	JJ	JJ	_	3	amod	_	_
3	cDNA	cdna	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	4	dobj	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	homologous	homologous	JJ	JJ	_	6	acl:relcl	_	_
10	to	to	TO	TO	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	C-terminal	c-terminal	JJ	JJ	_	15	amod	_	_
13	196	196	CD	CD	_	15	nummod	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	9	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	36-kDa	36-kda	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	YB-1	yb-1	NN	NN	_	20	appos	_	_
23	.	.	.	.	_	4	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	YB-1	yb-1	NN	NN	_	6	compound	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	plasmid	plasmid	NN	NN	_	1	nmod	_	_
7	increases	increase	VBZ	VBZ	_	0	root	_	_
8	HTLV-I	htlv-i	NN	NN	_	10	compound	_	_
9	basal	basal	JJ	JJ	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	7	dobj	_	_
11	approximately	approximately	RB	RB	_	12	advmod	_	_
12	14-fold	14-fold	RB	RB	_	7	advmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	On	on	IN	IN	_	7	case	_	_
2	the	the	DT	DT	_	7	dep	_	_
3	basis	basis	NN	NN	_	7	dep	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	weight	weight	NN	NN	_	19	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	characteristics	characteristic	NNS	NNS	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	in	in	FW	FW	_	16	amod	_	_
14	vivo	vivo	FW	FW	_	13	dep	_	_
15	transactivation	transactivation	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	7	conj	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	suggest	suggest	VBP	VBP	_	0	root	_	_
20	that	that	IN	IN	_	31	mark	_	_
21	the	the	DT	DT	_	26	det	_	_
22	previously	previously	RB	RB	_	23	advmod	_	_
23	identified	identify	VBN	VBN	_	26	amod	_	_
24	DRE	dre	NN	NN	_	25	nmod:npmod	_	_
25	1-binding	1-binding	JJ	JJ	_	26	amod	_	_
26	protein	protein	NN	NN	_	31	nsubj	_	_
27	,	,	,	,	_	26	punct	_	_
28	p37	p37	NN	NN	_	26	appos	_	_
29	,	,	,	,	_	26	punct	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	YB-1	yb-1	NN	NN	_	19	ccomp	_	_
32	.	.	.	.	_	19	punct	_	_

1	Chlorinated	chlorinate	VBN	VBN	_	2	amod	_	_
2	dibenzo-p-dioxins	dibenzo-p-dioxin	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	dibenzofurans	dibenzofuran	NNS	NNS	_	2	conj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	2	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	1	1	LS	LS	_	5	dep	_	_
2	.	.	.	.	_	1	punct	_	_
3	Blood	blood	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	volunteers	volunteer	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	moderately	moderately	RB	RB	_	10	advmod	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	body	body	NN	NN	_	12	compound	_	_
12	burdens	burden	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	12	advcl	_	_
2	monoclonal	monoclonal	JJ	JJ	_	3	amod	_	_
3	antibodies	antibody	NNS	NNS	_	1	dobj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	mAbs	mab	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	flow	flow	NN	NN	_	9	compound	_	_
9	cytometry	cytometry	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	studied	study	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	variety	variety	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	lymphocyte	lymphocyte	NN	NN	_	20	compound	_	_
20	subpopulations	subpopulation	NNS	NNS	_	12	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	workers	worker	NNS	NNS	_	20	nmod	_	_
23	with	with	IN	IN	_	27	case	_	_
24	moderately	moderately	RB	RB	_	25	advmod	_	_
25	increased	increase	VBN	VBN	_	27	amod	_	_
26	body	body	NN	NN	_	27	compound	_	_
27	burdens	burden	NNS	NNS	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NN	NN	_	27	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	TCDD	tcdd	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	of	of	IN	IN	_	37	case	_	_
35	other	other	JJ	JJ	_	37	amod	_	_
36	polychlorinated	polychlorinate	VBN	VBN	_	37	amod	_	_
37	dibenzo-p-dioxins	dibenzo-p-dioxin	NNS	NNS	_	29	conj	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	dibenzofurans	dibenzofuran	NNS	NNS	_	37	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	PCDD/PCDF	pcdd/pcdf	NN	NN	_	37	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	27	punct	_	_
44	expressed	express	VBN	VBN	_	27	acl	_	_
45	here	here	RB	RB	_	44	advmod	_	_
46	as	as	IN	IN	_	48	case	_	_
47	International-Toxicity	international-toxicity	NN	NN	_	48	compound	_	_
48	Equivalencies	equivalencies	NN	NN	_	44	nmod	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	I-TE	i-te	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	hypothesis	hypothesis	NN	NN	_	6	nsubj	_	_
3	to	to	TO	TO	_	5	mark	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	tested	test	VBN	VBN	_	2	acl	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	whether	whether	IN	IN	_	11	mark	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	not	not	RB	RB	_	7	mwe	_	_
10	humans	human	NNS	NNS	_	11	nsubj	_	_
11	exhibit	exhibit	VBP	VBP	_	6	advcl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	similar	similar	JJ	JJ	_	14	amod	_	_
14	susceptibility	susceptibility	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	PCDDs/PCDFs	pcdds/pcdfs	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	22	case	_	_
18	respect	respect	NN	NN	_	22	dep	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	surface	surface	NN	NN	_	22	compound	_	_
22	receptors	receptor	NNS	NNS	_	11	nmod	_	_
23	found	find	VBN	VBN	_	22	acl	_	_
24	previously	previously	RB	RB	_	23	advmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	respond	respond	VB	VB	_	23	xcomp	_	_
27	to	to	TO	TO	_	29	case	_	_
28	small	small	JJ	JJ	_	29	amod	_	_
29	doses	dose	NNS	NNS	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TCDD	tcdd	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	in	in	IN	IN	_	37	case	_	_
36	Callithrix	callithrix	FW	FW	_	37	compound	_	_
37	jacchus	jacchus	FW	FW	_	29	nmod	_	_
38	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	9	nsubj	_	_
2	are	be	VBP	VBP	_	9	cop	_	_
3	:	:	:	:	_	9	punct	_	_
4	helper-inducer	helper-inducer	JJ	JJ	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	memory	memory	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	0	root	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CD4+CD45R0+CD45RA-CD29highCD11a+	cd4+cd45r0+cd45ra-cd29highcd11a+	JJ	JJ	_	9	dep	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	CD20+	cd20+	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	cytotoxic	cytotoxic	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	9	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CD8+CD56+/CD57+	cd8+cd56+/cd57+	JJ	JJ	_	21	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	68	68	CD	CD	_	4	nummod	_	_
4	triple-labellings	triple-labelling	NNS	NNS	_	8	nsubjpass	_	_
5	with	with	IN	IN	_	6	case	_	_
6	mAbs	mab	NNS	NNS	_	4	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	performed	perform	VBN	VBN	_	0	root	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	each	each	DT	DT	_	14	det	_	_
14	volunteer	volunteer	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	possibly	possibly	RB	RB	_	17	advmod	_	_
17	generate	generate	VB	VB	_	8	xcomp	_	_
18	further	further	JJ	JJ	_	19	amod	_	_
19	hypotheses	hypothesis	NNS	NNS	_	17	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	evaluated	evaluate	VBN	VBN	_	0	root	_	_
4	whether	whether	IN	IN	_	11	mark	_	_
5	any	any	DT	DT	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	variables	variable	NNS	NNS	_	5	nmod	_	_
9	might	might	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	used	use	VBN	VBN	_	3	ccomp	_	_
12	as	as	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	biomarker	biomarker	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	effects	effect	NNS	NNS	_	14	nmod	_	_
17	for	for	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	class	class	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	compounds	compound	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	were	be	VBD	VBD	_	0	root	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	main	main	JJ	JJ	_	5	amod	_	_
5	goals	goal	NNS	NNS	_	2	nsubj	_	_
6	:	:	:	:	_	5	punct	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	11	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	evaluate	evaluate	VB	VB	_	5	dep	_	_
12	whether	whether	IN	IN	_	32	mark	_	_
13	workers	worker	NNS	NNS	_	32	nsubj	_	_
14	with	with	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	moderately	moderately	RB	RB	_	17	advmod	_	_
17	increased	increase	VBN	VBN	_	19	amod	_	_
18	PCDD/PCDF-body	pcdd/pcdf-body	NN	NN	_	19	compound	_	_
19	burden	burden	NN	NN	_	13	nmod	_	_
20	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
21	25-140	25-140	CD	CD	_	22	dep	_	_
22	ppt	ppt	NN	NN	_	23	dep	_	_
23	TCDD	tcdd	NN	NN	_	19	dep	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	104-522	104-522	CD	CD	_	26	dep	_	_
26	ppt	ppt	NN	NN	_	27	dep	_	_
27	I-TE	i-te	NN	NN	_	23	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	blood	blood	NN	NN	_	30	compound	_	_
30	fat	fat	NN	NN	_	23	nmod	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_
32	exhibit	exhibit	VBP	VBP	_	11	ccomp	_	_
33	changes	change	NNS	NNS	_	32	dobj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	surface	surface	NN	NN	_	37	compound	_	_
37	receptors	receptor	NNS	NNS	_	32	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	white	white	JJ	JJ	_	41	amod	_	_
40	blood	blood	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	37	nmod	_	_
42	,	,	,	,	_	32	punct	_	_
43	as	as	IN	IN	_	44	mark	_	_
44	observed	observe	VBN	VBN	_	32	advcl	_	_
45	in	in	IN	IN	_	47	case	_	_
46	previous	previous	JJ	JJ	_	47	amod	_	_
47	studies	study	NNS	NNS	_	44	nmod	_	_
48	in	in	IN	IN	_	50	case	_	_
49	non-human	non-human	JJ	JJ	_	50	amod	_	_
50	primates	primate	NNS	NNS	_	47	nmod	_	_
51	,	,	,	,	_	11	punct	_	_
52	and	and	CC	CC	_	11	cc	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	2	2	LS	LS	_	57	dep	_	_
55	)	)	-RRB-	-RRB-	_	54	punct	_	_
56	to	to	TO	TO	_	57	mark	_	_
57	clarify	clarify	VB	VB	_	11	conj	_	_
58	whether	whether	IN	IN	_	88	mark	_	_
59	persons	person	NNS	NNS	_	88	nsubj	_	_
60	at	at	IN	IN	_	63	case	_	_
61	the	the	DT	DT	_	63	det	_	_
62	upper	upper	JJ	JJ	_	63	amod	_	_
63	range	range	NN	NN	_	59	nmod	_	_
64	-LSB-	-lsb-	-LRB-	-LRB-	_	67	punct	_	_
65	10-23	10-23	CD	CD	_	66	dep	_	_
66	ppt	ppt	NN	NN	_	67	dep	_	_
67	TCDD	tcdd	NN	NN	_	63	dep	_	_
68	or	or	CC	CC	_	67	cc	_	_
69	30-90	30-90	CD	CD	_	70	dep	_	_
70	ppt	ppt	NN	NN	_	71	dep	_	_
71	I-TE	i-te	NN	NN	_	67	conj	_	_
72	in	in	IN	IN	_	74	case	_	_
73	blood	blood	NN	NN	_	74	compound	_	_
74	fat	fat	NN	NN	_	67	nmod	_	_
75	-RSB-	-rsb-	-RRB-	-RRB-	_	67	punct	_	_
76	of	of	IN	IN	_	81	case	_	_
77	the	the	DT	DT	_	81	det	_	_
78	body	body	NN	NN	_	81	compound	_	_
79	burden	burden	NN	NN	_	81	compound	_	_
80	reference	reference	NN	NN	_	81	compound	_	_
81	values	value	NNS	NNS	_	63	nmod	_	_
82	of	of	IN	IN	_	87	case	_	_
83	a	a	DT	DT	_	87	det	_	_
84	not	not	RB	RB	_	85	dep	_	_
85	particularly	particularly	RB	RB	_	86	advmod	_	_
86	exposed	expose	VBN	VBN	_	87	amod	_	_
87	population	population	NN	NN	_	63	nmod	_	_
88	show	show	VBP	VBP	_	57	ccomp	_	_
89	detectable	detectable	JJ	JJ	_	90	amod	_	_
90	deviations	deviation	NNS	NNS	_	88	dobj	_	_
91	in	in	IN	IN	_	94	case	_	_
92	these	these	DT	DT	_	94	det	_	_
93	immunological	immunological	JJ	JJ	_	94	amod	_	_
94	variables	variable	NNS	NNS	_	88	nmod	_	_
95	,	,	,	,	_	88	punct	_	_
96	when	when	WRB	WRB	_	97	advmod	_	_
97	compared	compare	VBN	VBN	_	88	advcl	_	_
98	with	with	IN	IN	_	99	case	_	_
99	persons	person	NNS	NNS	_	97	nmod	_	_
100	at	at	IN	IN	_	105	case	_	_
101	the	the	DT	DT	_	105	det	_	_
102	lower	lower	JJR	JJR	_	105	amod	_	_
103	and	and	CC	CC	_	102	cc	_	_
104	medium	medium	NN	NN	_	102	conj	_	_
105	range	range	NN	NN	_	99	nmod	_	_
106	-LSB-	-lsb-	-LRB-	-LRB-	_	109	punct	_	_
107	1-3	1-3	CD	CD	_	108	dep	_	_
108	ppt	ppt	NN	NN	_	109	dep	_	_
109	TCDD	tcdd	NN	NN	_	105	dep	_	_
110	or	or	CC	CC	_	109	cc	_	_
111	9-29	9-29	CD	CD	_	112	dep	_	_
112	ppt	ppt	NN	NN	_	113	dep	_	_
113	I-TE	i-te	NN	NN	_	109	conj	_	_
114	-RSB-	-rsb-	-RRB-	-RRB-	_	109	punct	_	_
115	of	of	IN	IN	_	120	case	_	_
116	these	these	DT	DT	_	120	det	_	_
117	body	body	NN	NN	_	120	compound	_	_
118	burden	burden	NN	NN	_	120	compound	_	_
119	reference	reference	NN	NN	_	120	compound	_	_
120	values	value	NNS	NNS	_	105	nmod	_	_
121	.	.	.	.	_	2	punct	_	_

1	Regression	regression	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	2	nmod	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	slight	slight	JJ	JJ	_	8	amod	_	_
8	trends	trend	NNS	NNS	_	6	dobj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	some	some	DT	DT	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	biomarkers	biomarker	NNS	NNS	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	e.g.	e.g.	FW	FW	_	16	advmod	_	_
16	CD45R0+	cd45r0+	JJ	JJ	_	10	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	6	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	one	one	CD	CD	_	3	nummod	_	_
3	exception	exception	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	these	these	DT	DT	_	8	nsubj	_	_
6	were	be	VBD	VBD	_	8	cop	_	_
7	all	all	DT	DT	_	8	advmod	_	_
8	increases	increase	NNS	NNS	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	None	none	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	alterations	alteration	NNS	NNS	_	1	nmod	_	_
5	observed	observe	VBN	VBN	_	4	acl	_	_
6	are	be	VBP	VBP	_	9	cop	_	_
7	of	of	IN	IN	_	9	case	_	_
8	medical	medical	JJ	JJ	_	9	amod	_	_
9	relevance	relevance	NN	NN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	slight	slight	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	percentage	percentage	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CD4+CD45R0+	cd4+cd45r0+	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	remained	remain	VBD	VBD	_	0	root	_	_
11	significant	significant	JJ	JJ	_	10	xcomp	_	_
12	even	even	RB	RB	_	15	advmod	_	_
13	after	after	IN	IN	_	15	case	_	_
14	covariant	covariant	JJ	JJ	_	15	amod	_	_
15	analysis	analysis	NN	NN	_	10	nmod	_	_
16	taking	take	VBG	VBG	_	15	acl	_	_
17	age-related	age-related	JJ	JJ	_	18	amod	_	_
18	changes	change	NNS	NNS	_	16	dobj	_	_
19	into	into	IN	IN	_	20	case	_	_
20	account	account	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Altogether	altogether	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	7	nsubj	_	_
5	do	do	VBP	VBP	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	provide	provide	VB	VB	_	0	root	_	_
8	any	any	DT	DT	_	9	det	_	_
9	evidence	evidence	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	support	support	VB	VB	_	9	acl	_	_
12	an	a	DT	DT	_	13	det	_	_
13	assumption	assumption	NN	NN	_	11	dobj	_	_
14	that	that	IN	IN	_	23	mark	_	_
15	moderately	moderately	RB	RB	_	16	advmod	_	_
16	increased	increase	VBN	VBN	_	18	amod	_	_
17	body	body	NN	NN	_	18	compound	_	_
18	burdens	burden	NNS	NNS	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	PCDDs/PCDFs	pcdds/pcdfs	NNS	NNS	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	adults	adult	NNS	NNS	_	18	nmod	_	_
23	induce	induce	VBP	VBP	_	13	ccomp	_	_
24	decreases	decrease	NNS	NNS	_	23	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	cellular	cellular	JJ	JJ	_	28	amod	_	_
28	components	component	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	human	human	JJ	JJ	_	33	amod	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	system	system	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Adult	adult	JJ	JJ	_	2	amod	_	_
2	humans	human	NNS	NNS	_	6	nsubj	_	_
3	certainly	certainly	RB	RB	_	6	advmod	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	less	less	RBR	RBR	_	6	advmod	_	_
6	susceptible	susceptible	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	action	action	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PCDDs/PCDFs	pcdds/pcdfs	NNS	NNS	_	9	nmod	_	_
12	than	than	IN	IN	_	15	case	_	_
13	adolescent	adolescent	JJ	JJ	_	15	amod	_	_
14	Callithrix	callithrix	FW	FW	_	15	compound	_	_
15	jacchus	jacchus	FW	FW	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	lymphotoxin	lymphotoxin	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	stimulated	stimulate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	HTLV-I	htlv-i	NN	NN	_	9	compound	_	_
8	tax	tax	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	HTLV-I	htlv-i	NN	NN	_	5	compound	_	_
3	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
4	activator	activator	NN	NN	_	5	compound	_	_
5	tax	tax	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	gain	gain	VB	VB	_	7	xcomp	_	_
10	insight	insight	NN	NN	_	9	dobj	_	_
11	into	into	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	mechanism	mechanism	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	22	case	_	_
15	lymphotoxin	lymphotoxin	NN	NN	_	22	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LT	lt	NN	NN	_	15	appos	_	_
18	;	;	:	:	_	17	punct	_	_
19	TNF-beta	tnf-beta	NN	NN	_	17	dep	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	induction	induction	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Tax-expressing	tax-expressing	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	4	nsubj	_	_
4	produce	produce	VBP	VBP	_	0	root	_	_
5	LT	lt	NN	NN	_	7	compound	_	_
6	biologic	biologic	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	8	det	_	_
2	LT	lt	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	LT-293	lt-293	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	CAT	cat	NN	NN	_	8	compound	_	_
8	construct	construct	NN	NN	_	16	nsubj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	contained	contain	VBD	VBD	_	8	acl:relcl	_	_
11	an	a	DT	DT	_	14	det	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	10	dobj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	active	active	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	LT-producing	lt-producing	JJ	JJ	_	22	amod	_	_
20	C81-66-45	c81-66-45	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	contains	contain	VBZ	VBZ	_	22	acl:relcl	_	_
26	defective	defective	JJ	JJ	_	27	amod	_	_
27	HTLV-I	htlv-i	NN	NN	_	25	dobj	_	_
28	but	but	CC	CC	_	25	cc	_	_
29	expresses	express	VBZ	VBZ	_	25	conj	_	_
30	tax	tax	NN	NN	_	29	dobj	_	_
31	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	17	nsubj	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	a	a	DT	DT	_	8	det	_	_
5	mutated	mutate	VBN	VBN	_	8	amod	_	_
6	LT-kappa	lt-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	construct	construct	NN	NN	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	M1-CAT	m1-cat	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	inactive	inactive	JJ	JJ	_	2	ccomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	C81-66-45	c81-66-45	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	confirmed	confirm	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	importance	importance	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	LT	lt	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Tax	tax	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	transfected	transfect	VBN	VBN	_	0	root	_	_
4	into	into	IN	IN	_	8	case	_	_
5	HTLV-I-negative	htlv-i-negative	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Jurkat	jurkat	NN	NN	_	3	compound	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nsubj	_	_
4	stably	stably	RB	RB	_	5	advmod	_	_
5	expressing	express	VBG	VBG	_	3	acl	_	_
6	tax	tax	NN	NN	_	5	dobj	_	_
7	contained	contain	VBD	VBD	_	0	root	_	_
8	elevated	elevated	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	directly	directly	RB	RB	_	15	advmod	_	_
15	bound	bind	VBD	VBD	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	LT-kappa	lt-kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Tax	tax	NN	NN	_	10	nsubj	_	_
2	co-transfected	co-transfect	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	5	case	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	2	nmod	_	_
6	into	into	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	maximally	maximally	RB	RB	_	10	advmod	_	_
10	activated	activate	VBD	VBD	_	0	root	_	_
11	HTLV-I-LTR-CAT	htlv-i-ltr-cat	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B-fos-CAT	b-fos-cat	NN	NN	_	11	conj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	also	also	RB	RB	_	10	advmod	_	_
17	activated	activate	VBD	VBD	_	10	dep	_	_
18	LT-293	lt-293	NN	NN	_	17	dobj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	lesser	lesser	JJR	JJR	_	22	amod	_	_
22	extent	extent	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	JM	jm	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	tax	tax	NN	NN	_	7	nsubj	_	_
7	induced	induced	JJ	JJ	_	0	root	_	_
8	LT-293	lt-293	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	two-	two-	CD	CD	_	7	nmod	_	_
12	to	to	TO	TO	_	11	dep	_	_
13	four-fold	four-fold	JJ	JJ	_	11	dep	_	_
14	,	,	,	,	_	7	punct	_	_
15	though	though	IN	IN	_	17	mark	_	_
16	there	there	EX	EX	_	17	expl	_	_
17	was	be	VBD	VBD	_	7	advcl	_	_
18	no	no	DT	DT	_	19	neg	_	_
19	induction	induction	NN	NN	_	17	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	M1-CAT	m1-cat	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	LT-293	lt-293	NN	NN	_	6	compound	_	_
5	CAT	cat	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	mirrored	mirror	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	increase	increase	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	LT	lt	NN	NN	_	13	compound	_	_
12	biologic	biologic	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	seen	see	VBN	VBN	_	9	acl	_	_
15	under	under	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	conditions	condition	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	2	appos	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	induction	induction	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	LT	lt	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	over	over	IN	IN	_	15	case	_	_
14	basal	basal	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	8	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	indicate	indicate	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	HTLV-I	htlv-i	NN	NN	_	20	compound	_	_
20	tax	tax	NN	NN	_	21	nsubj	_	_
21	causes	cause	VBZ	VBZ	_	17	ccomp	_	_
22	low-level	low-level	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	both	both	CC	CC	_	27	cc:preconj	_	_
26	endogenous	endogenous	JJ	JJ	_	27	amod	_	_
27	LT	lt	NN	NN	_	23	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	the	the	DT	DT	_	31	det	_	_
30	LT	lt	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	21	punct	_	_
33	at	at	IN	IN	_	36	advmod	_	_
34	least	least	JJS	JJS	_	33	mwe	_	_
35	in	in	IN	IN	_	36	case	_	_
36	part	part	NN	NN	_	38	nmod	_	_
37	through	through	IN	IN	_	38	case	_	_
38	activation	activation	NN	NN	_	21	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	NF-kappa	nf-kappa	NN	NN	_	41	compound	_	_
41	B	b	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	17	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	obstructive	obstructive	JJ	JJ	_	6	amod	_	_
5	renal	renal	JJ	JJ	_	6	amod	_	_
6	disease	disease	NN	NN	_	2	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	transient	transient	JJ	JJ	_	9	amod	_	_
9	reduction	reduction	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	lymphocytic	lymphocytic	JJ	JJ	_	13	amod	_	_
12	aldosterone	aldosterone	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Results	result	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	affected	affected	JJ	JJ	_	5	amod	_	_
5	infants	infant	NNS	NNS	_	1	nmod	_	_
6	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	two	two	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	2	dobj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	transient	transient	JJ	JJ	_	7	amod	_	_
7	pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	4	nmod	_	_
8	due	due	JJ	JJ	_	12	case	_	_
9	to	to	TO	TO	_	8	mwe	_	_
10	obstructive	obstructive	JJ	JJ	_	12	amod	_	_
11	renal	renal	JJ	JJ	_	12	amod	_	_
12	disease	disease	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	3	nsubj	_	_
3	presented	present	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	10	case	_	_
5	a	a	DT	DT	_	10	det	_	_
6	salt-losing	salt-losing	JJ	JJ	_	10	amod	_	_
7	episode	episode	NN	NN	_	10	compound	_	_
8	simulating	simulate	VBG	VBG	_	10	amod	_	_
9	adrenal	adrenal	JJ	JJ	_	10	amod	_	_
10	insufficiency	insufficiency	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	one	one	CD	CD	_	3	nummod	_	_
3	patient	patient	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	transient	transient	JJ	JJ	_	6	amod	_	_
6	reduction	reduction	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	aldosterone	aldosterone	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	6	nmod	_	_
10	could	could	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	documented	document	VBN	VBN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	while	while	IN	IN	_	25	mark	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	second	second	JJ	JJ	_	18	amod	_	_
18	patient	patient	NN	NN	_	25	nmod	_	_
19	the	the	DT	DT	_	23	det	_	_
20	clinical	clinical	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	biochemical	biochemical	JJ	JJ	_	20	conj	_	_
23	parameters	parameter	NNS	NNS	_	25	nsubj	_	_
24	were	be	VBD	VBD	_	25	cop	_	_
25	consistent	consistent	JJ	JJ	_	12	advcl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	transient	transient	JJ	JJ	_	28	amod	_	_
28	pseudohypoaldosteronism	pseudohypoaldosteronism	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Aldosterone	aldosterone	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	normal	normal	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	both	both	DT	DT	_	7	det	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	when	when	IN	IN	_	9	advmod	_	_
9	studied	study	VBN	VBN	_	4	dep	_	_
10	after	after	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	surgical	surgical	JJ	JJ	_	13	amod	_	_
13	correction	correction	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	obstruction	obstruction	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	macrophage	macrophage	NN	NN	_	5	compound	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	PU.1	pu.1	NN	NN	_	6	nsubj	_	_
6	directs	direct	VBZ	VBZ	_	0	root	_	_
7	tissue-specific	tissue-specific	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	macrophage	macrophage	NN	NN	_	14	compound	_	_
12	colony-stimulating	colony-stimulating	JJ	JJ	_	14	amod	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	macrophage	macrophage	NN	NN	_	4	compound	_	_
3	colony-stimulating	colony-stimulating	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	M-CSF	m-csf	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	receptor	receptor	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	14	amod	_	_
14	fashion	fashion	NN	NN	_	10	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	promoters	promoter	NNS	NNS	_	10	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	23	det	_	_
23	placenta	placenta	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	5	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	5	dep	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	understand	understand	VB	VB	_	26	advcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	dobj	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	play	play	VBP	VBP	_	8	acl:relcl	_	_
11	a	a	DT	DT	_	12	det	_	_
12	role	role	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	commitment	commitment	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	multipotential	multipotential	JJ	JJ	_	18	amod	_	_
18	progenitors	progenitor	NNS	NNS	_	15	nmod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	monocyte/macrophage	monocyte/macrophage	NN	NN	_	22	compound	_	_
22	lineage	lineage	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	26	punct	_	_
24	we	we	PRP	PRP	_	26	nsubj	_	_
25	have	have	VBP	VBP	_	26	aux	_	_
26	initiated	initiate	VBN	VBN	_	0	root	_	_
27	an	a	DT	DT	_	28	det	_	_
28	investigation	investigation	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	factors	factor	NNS	NNS	_	28	nmod	_	_
32	which	which	WDT	WDT	_	33	nsubj	_	_
33	activate	activate	VBP	VBP	_	31	acl:relcl	_	_
34	the	the	DT	DT	_	36	det	_	_
35	M-CSF	m-csf	NN	NN	_	36	compound	_	_
36	receptor	receptor	NN	NN	_	33	dobj	_	_
37	very	very	RB	RB	_	38	advmod	_	_
38	early	early	RB	RB	_	33	advmod	_	_
39	during	during	IN	IN	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	monocyte	monocyte	NN	NN	_	43	compound	_	_
42	differentiation	differentiation	NN	NN	_	43	compound	_	_
43	process	process	NN	NN	_	33	nmod	_	_
44	.	.	.	.	_	26	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
8	M-CSF	m-csf	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	11	nsubj	_	_
11	directs	direct	VBZ	VBZ	_	3	ccomp	_	_
12	reporter	reporter	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	tissue-specific	tissue-specific	JJ	JJ	_	18	amod	_	_
18	fashion	fashion	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	25	mark	_	_
2	one	one	CD	CD	_	25	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	few	few	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	which	which	WDT	WDT	_	11	nsubjpass	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	implicated	implicate	VBN	VBN	_	7	acl:relcl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	monocyte	monocyte	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	25	cop	_	_
19	the	the	DT	DT	_	25	det	_	_
20	macrophage-	macrophage-	NN	NN	_	25	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	B-cell-specific	b-cell-specific	JJ	JJ	_	20	conj	_	_
23	PU.1	pu.1	NN	NN	_	25	compound	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	28	advcl	_	_
26	,	,	,	,	_	28	punct	_	_
27	we	we	PRP	PRP	_	28	nsubj	_	_
28	investigated	investigate	VBD	VBD	_	0	root	_	_
29	whether	whether	IN	IN	_	31	mark	_	_
30	PU.1	pu.1	NN	NN	_	31	nsubj	_	_
31	binds	bind	VBZ	VBZ	_	28	ccomp	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	activates	activate	VBZ	VBZ	_	31	conj	_	_
34	the	the	DT	DT	_	37	det	_	_
35	M-CSF	m-csf	NN	NN	_	37	compound	_	_
36	receptor	receptor	NN	NN	_	37	compound	_	_
37	promoter	promoter	NN	NN	_	31	dobj	_	_
38	.	.	.	.	_	28	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	both	both	CC	CC	_	8	cc:preconj	_	_
6	in	in	FW	FW	_	7	dep	_	_
7	vitro-translated	vitro-translate	VBN	VBN	_	8	amod	_	_
8	PU.1	pu.1	NN	NN	_	14	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	PU.1	pu.1	NN	NN	_	8	conj	_	_
11	from	from	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	10	nmod	_	_
14	bind	bind	VBP	VBP	_	3	ccomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	site	site	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	M-CSF	m-csf	NN	NN	_	23	compound	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	18	nmod	_	_
24	just	just	RB	RB	_	25	advmod	_	_
25	upstream	upstream	JJ	JJ	_	18	advmod	_	_
26	from	from	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	major	major	JJ	JJ	_	31	amod	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	initiation	initiation	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Mutations	mutation	NNS	NNS	_	9	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	1	nmod	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	eliminate	eliminate	VB	VB	_	1	acl:relcl	_	_
7	PU.1	pu.1	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	decrease	decrease	VBP	VBP	_	0	root	_	_
10	M-CSF	m-csf	NN	NN	_	13	compound	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	significantly	significantly	RB	RB	_	9	advmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	macrophage	macrophage	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	9	nmod	_	_
19	only	only	RB	RB	_	18	advmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	PU.1	pu.1	NN	NN	_	4	nsubj	_	_
4	transactivates	transactivate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	M-CSF	m-csf	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	nonmacrophage	nonmacrophage	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	PU.1	pu.1	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	major	major	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	macrophage	macrophage	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	regulation	regulation	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	development	development	NN	NN	_	13	conj	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	directing	direct	VBG	VBG	_	6	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	receptor	receptor	NN	NN	_	19	nmod	_	_
23	for	for	IN	IN	_	28	case	_	_
24	a	a	DT	DT	_	28	det	_	_
25	key	key	JJ	JJ	_	28	amod	_	_
26	macrophage	macrophage	NN	NN	_	28	compound	_	_
27	growth	growth	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	5	amod	_	_
2	natural	natural	JJ	JJ	_	5	amod	_	_
3	killer	killer	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	6	nsubj	_	_
6	correlates	correlate	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	low	low	JJ	JJ	_	11	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	negative	negative	JJ	JJ	_	8	conj	_	_
11	expression	expression	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HER-2/neu	her-2/neu	NN	NN	_	15	compound	_	_
15	oncogene	oncogene	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	11	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	breast	breast	NN	NN	_	20	compound	_	_
20	cancer	cancer	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	HER-2/neu	her-2/neu	NN	NN	_	6	compound	_	_
6	oncogene	oncogene	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	breast	breast	NN	NN	_	9	compound	_	_
9	cancer	cancer	NN	NN	_	2	nmod	_	_
10	correlates	correlate	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	15	case	_	_
12	decreased	decrease	VBN	VBN	_	15	amod	_	_
13	estrogen	estrogen	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	concentration	concentration	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	seems	seem	VBZ	VBZ	_	10	conj	_	_
18	to	to	TO	TO	_	23	mark	_	_
19	be	be	VB	VB	_	23	cop	_	_
20	an	a	DT	DT	_	23	det	_	_
21	important	important	JJ	JJ	_	23	amod	_	_
22	prognostic	prognostic	JJ	JJ	_	23	amod	_	_
23	factor	factor	NN	NN	_	17	xcomp	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	is	be	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	correlation	correlation	NN	NN	_	6	nsubj	_	_
9	between	between	IN	IN	_	11	case	_	_
10	HER-2/neu	her-2/neu	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	immunologic	immunologic	JJ	JJ	_	14	amod	_	_
14	parameters	parameter	NNS	NNS	_	11	conj	_	_
15	representing	represent	VBG	VBG	_	14	acl	_	_
16	tumor	tumor	NN	NN	_	17	compound	_	_
17	defense	defense	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	11	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	breast	breast	NN	NN	_	22	compound	_	_
22	cancer	cancer	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	METHOD	method	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	Western	western	JJ	JJ	_	4	amod	_	_
3	blot	blot	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	investigate	investigate	VB	VB	_	6	xcomp	_	_
9	HER-2/neu	her-2/neu	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	whereas	whereas	IN	IN	_	6	dep	_	_
13	a	a	DT	DT	_	15	det	_	_
14	chromium-release	chromium-release	NN	NN	_	15	compound	_	_
15	assay	assay	NN	NN	_	24	nsubjpass	_	_
16	using	use	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	K562	k562	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	16	dobj	_	_
21	as	as	IN	IN	_	22	case	_	_
22	target	target	NN	NN	_	16	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	used	use	VBN	VBN	_	6	parataxis	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	measure	measure	VB	VB	_	24	xcomp	_	_
27	natural	natural	JJ	JJ	_	28	amod	_	_
28	killer	killer	NN	NN	_	33	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	NK	nk	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	26	dobj	_	_
34	.	.	.	.	_	6	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	12	nmod	_	_
3	with	with	IN	IN	_	5	case	_	_
4	breast	breast	NN	NN	_	5	compound	_	_
5	cancer	cancer	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	NK	nk	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	12	nsubj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	higher	higher	JJR	JJR	_	0	root	_	_
13	compared	compare	VBN	VBN	_	15	case	_	_
14	with	with	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	12	advcl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	benign	benign	JJ	JJ	_	18	amod	_	_
18	tumors	tumor	NNS	NNS	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	P	p	NN	NN	_	21	nsubj	_	_
21	=	=	JJ	JJ	_	15	dep	_	_
22	0.006	0.006	CD	CD	_	21	dobj	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	or	or	CC	CC	_	15	cc	_	_
25	healthy	healthy	JJ	JJ	_	27	amod	_	_
26	control	control	NN	NN	_	27	compound	_	_
27	subjects	subject	NNS	NNS	_	15	conj	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	P	p	NN	NN	_	30	nsubj	_	_
30	=	=	JJ	JJ	_	27	dep	_	_
31	0.002	0.002	CD	CD	_	30	dobj	_	_
32	)	)	-RRB-	-RRB-	_	30	punct	_	_
33	.	.	.	.	_	12	punct	_	_

1	Moreover	moreover	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	23.3	23.3	CD	CD	_	4	nummod	_	_
4	%	%	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	breast	breast	NN	NN	_	9	compound	_	_
9	cancer	cancer	NN	NN	_	6	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	12	det	_	_
12	overexpression	overexpression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HER-2/neu	her-2/neu	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	group	group	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	NK	nk	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	12	nsubj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	lower	lower	JJR	JJR	_	0	root	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	45.6	45.6	CD	CD	_	17	nummod	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	16.1	16.1	CD	CD	_	14	conj	_	_
17	%	%	NN	NN	_	12	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	compared	compare	VBN	VBN	_	22	case	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	group	group	NN	NN	_	12	advcl	_	_
23	with	with	IN	IN	_	26	case	_	_
24	no	no	DT	DT	_	26	neg	_	_
25	HER-2/neu	her-2/neu	NN	NN	_	26	compound	_	_
26	overexpression	overexpression	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	31	punct	_	_
28	57.3	57.3	CD	CD	_	31	nummod	_	_
29	+/-	+/-	CC	CC	_	28	cc	_	_
30	11.0	11.0	CD	CD	_	28	conj	_	_
31	%	%	NN	NN	_	22	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	12	punct	_	_

1	NK	nk	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	increase	increase	VB	VB	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	HER-2/neu	her-2/neu	NN	NN	_	11	compound	_	_
11	overexpression	overexpression	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	statistically	statistically	RB	RB	_	7	advmod	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	correlation	correlation	NN	NN	_	4	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	cytolytic	cytolytic	JJ	JJ	_	13	amod	_	_
11	effector	effector	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	function	function	NN	NN	_	8	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	HER-2/neu	her-2/neu	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	8	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	tumor	tumor	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	P	p	NN	NN	_	22	nsubj	_	_
22	=	=	JJ	JJ	_	16	dep	_	_
23	0.003	0.003	CD	CD	_	22	dobj	_	_
24	)	)	-RRB-	-RRB-	_	22	punct	_	_
25	,	,	,	,	_	16	punct	_	_
26	and	and	CC	CC	_	16	cc	_	_
27	HER-2/neu	her-2/neu	NN	NN	_	28	compound	_	_
28	overexpression	overexpression	NN	NN	_	16	conj	_	_
29	correlated	correlate	VBD	VBD	_	28	acl	_	_
30	with	with	IN	IN	_	35	case	_	_
31	a	a	DT	DT	_	35	det	_	_
32	negative	negative	JJ	JJ	_	35	amod	_	_
33	estrogen	estrogen	NN	NN	_	35	compound	_	_
34	receptor	receptor	NN	NN	_	35	compound	_	_
35	status	status	NN	NN	_	29	nmod	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	P	p	NN	NN	_	38	nsubj	_	_
38	=	=	JJ	JJ	_	28	dep	_	_
39	0.005	0.005	CD	CD	_	38	dobj	_	_
40	)	)	-RRB-	-RRB-	_	38	punct	_	_
41	.	.	.	.	_	4	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	add	add	VBP	VBP	_	0	root	_	_
4	further	further	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	previous	previous	JJ	JJ	_	8	amod	_	_
8	observations	observation	NNS	NNS	_	3	nmod	_	_
9	from	from	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	authors	author	NNS	NNS	_	13	nmod:poss	_	_
12	'	'	POS	POS	_	11	case	_	_
13	laboratory	laboratory	NN	NN	_	8	nmod	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	certain	certain	JJ	JJ	_	17	amod	_	_
16	tumor	tumor	NN	NN	_	17	compound	_	_
17	characteristics	characteristic	NNS	NNS	_	20	nsubjpass	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	associated	associate	VBN	VBN	_	8	dep	_	_
21	with	with	IN	IN	_	22	case	_	_
22	reactions	reaction	NNS	NNS	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	host	host	NN	NN	_	22	nmod	_	_
26	with	with	IN	IN	_	28	case	_	_
27	breast	breast	NN	NN	_	28	compound	_	_
28	cancer	cancer	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	conj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	vanadate	vanadate	NN	NN	_	10	compound	_	_
10	peroxide	peroxide	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	17	case	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphatases	phosphatase	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Rapid	rapid	JJ	JJ	_	3	amod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	key	key	JJ	JJ	_	7	amod	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	crucial	crucial	JJ	JJ	_	11	amod	_	_
11	event	event	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	transduction	transduction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	activation	activation	NN	NN	_	17	compound	_	_
17	signals	signal	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	T-lymphocytes	t-lymphocyte	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphatases	phosphatase	NNS	NNS	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PTPases	ptpase	NNS	NNS	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	process	process	NN	NN	_	3	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	explored	explore	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	studying	study	VBG	VBG	_	15	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	effects	effect	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	powerful	powerful	JJ	JJ	_	24	amod	_	_
23	PTPase	ptpase	NN	NN	_	24	compound	_	_
24	inhibitor	inhibitor	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	vanadate	vanadate	NN	NN	_	27	compound	_	_
27	peroxide	peroxide	NN	NN	_	24	appos	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	pervanadate	pervanadate	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	24	punct	_	_
32	on	on	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	activation	activation	NN	NN	_	35	compound	_	_
35	cascade	cascade	NN	NN	_	19	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	Jurkat	jurkat	NN	NN	_	40	compound	_	_
38	human	human	JJ	JJ	_	40	amod	_	_
39	leukaemic	leukaemic	JJ	JJ	_	40	amod	_	_
40	T-cells	t-cell	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	15	punct	_	_

1	Pervanadate	pervanadate	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	kinases	kinase	NNS	NNS	_	3	nmod	_	_
8	lck	lck	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	fyn	fyn	NN	NN	_	8	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	4-	4-	CD	CD	_	3	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	3-fold	3-fold	JJ	JJ	_	12	conj	_	_
15	respectively	respectively	RB	RB	_	12	advmod	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	dramatic	dramatic	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	3	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	cellular	cellular	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	notably	notably	RB	RB	_	31	advmod	_	_
29	phospholipase	phospholipase	NN	NN	_	31	compound	_	_
30	C	c	NN	NN	_	31	compound	_	_
31	gamma	gamma	NN	NN	_	26	appos	_	_
32	1	1	CD	CD	_	31	nummod	_	_
33	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	event	event	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	observed	observe	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	rise	rise	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
11	Ca2+	ca2+	NN	NN	_	12	compound	_	_
12	concentration	concentration	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	corresponding	correspond	VBG	VBG	_	8	acl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	an	a	DT	DT	_	17	det	_	_
17	influx	influx	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	3	nsubj	_	_
3	required	require	VBD	VBD	_	0	root	_	_
4	surface	surface	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CD45	cd45	NN	NN	_	9	compound	_	_
9	PTPase	ptpase	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	observed	observe	VBN	VBN	_	3	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	CD45-deficient	cd45-deficient	JJ	JJ	_	16	amod	_	_
16	variants	variant	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	Jurkat	jurkat	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	CD45-negative	cd45-negative	JJ	JJ	_	4	amod	_	_
4	variant	variant	NN	NN	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	15	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	pervanadate	pervanadate	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	globally	globally	RB	RB	_	15	advmod	_	_
15	decreased	decrease	VBN	VBN	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	some	some	DT	DT	_	19	det	_	_
18	phosphorylated	phosphorylate	VBN	VBN	_	19	amod	_	_
19	substrates	substrate	NNS	NNS	_	22	nsubj	_	_
20	were	be	VBD	VBD	_	22	cop	_	_
21	specifically	specifically	RB	RB	_	22	advmod	_	_
22	missing	missing	JJ	JJ	_	15	conj	_	_
23	.	.	.	.	_	15	punct	_	_

1	Pervanadate	pervanadate	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	stimulated	stimulate	VBD	VBD	_	0	root	_	_
4	transcription	transcription	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	accumulation	accumulation	NN	NN	_	4	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	mRNA	mrna	NN	NN	_	10	nmod	_	_
14	as	as	RB	RB	_	4	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	several	several	JJ	JJ	_	19	amod	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	hallmarks	hallmark	NNS	NNS	_	4	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T-lymphocyte	t-lymphocyte	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	such	such	JJ	JJ	_	26	case	_	_
24	as	as	IN	IN	_	23	mwe	_	_
25	surface	surface	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	19	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	CD69	cd69	NN	NN	_	30	compound	_	_
30	antigen	antigen	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	36	det	_	_
33	interleukin	interleukin	NN	NN	_	36	compound	_	_
34	2	2	CD	CD	_	36	nummod	_	_
35	receptor	receptor	NN	NN	_	36	compound	_	_
36	alpha-chain	alpha-chain	NN	NN	_	30	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	CD25	cd25	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	3	punct	_	_

1	Pervanadate	pervanadate	NN	NN	_	2	nsubj	_	_
2	synergized	synergize	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	signals	signal	NNS	NNS	_	2	nmod	_	_
5	delivered	deliver	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	10	case	_	_
7	T-cell	t-cell	NN	NN	_	10	compound	_	_
8	antigen	antigen	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	engagement	engagement	NN	NN	_	5	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	phorbol	phorbol	NN	NN	_	15	compound	_	_
15	ester	ester	NN	NN	_	10	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	2	xcomp	_	_
18	interleukin	interleukin	NN	NN	_	20	compound	_	_
19	2	2	CD	CD	_	20	nummod	_	_
20	production	production	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Pervanadate	pervanadate	NN	NN	_	2	nsubj	_	_
2	activated	activate	VBD	VBD	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	shown	show	VBN	VBN	_	2	advcl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	this	this	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	thus	thus	RB	RB	_	3	advmod	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	PTPases	ptpase	NNS	NNS	_	6	nsubj	_	_
6	play	play	VBP	VBP	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	crucial	crucial	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	negative	negative	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	signal	signal	NN	NN	_	16	compound	_	_
16	transduction	transduction	NN	NN	_	13	nmod	_	_
17	culminating	culminate	VBG	VBG	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T-lymphocyte	t-lymphocyte	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	induction	induction	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	3	nmod	_	_
7	appears	appear	VBZ	VBZ	_	0	root	_	_
8	sufficient	sufficient	JJ	JJ	_	7	xcomp	_	_
9	per	per	FW	FW	_	10	compound	_	_
10	se	se	FW	FW	_	8	advmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	initiate	initiate	VB	VB	_	8	xcomp	_	_
13	a	a	DT	DT	_	16	det	_	_
14	complete	complete	JJ	JJ	_	16	amod	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	programme	programme	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	7	punct	_	_

1	Steroid-resistant	steroid-resistant	JJ	JJ	_	2	amod	_	_
2	asthma	asthma	NN	NN	_	0	root	_	_
3	.	.	.	.	_	2	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
3	contributing	contribute	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	6	case	_	_
5	inadequate	inadequate	JJ	JJ	_	6	amod	_	_
6	response	response	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	therapy	therapy	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	14	mark	_	_
6	alterations	alteration	NNS	NNS	_	14	nsubj	_	_
7	in	in	IN	IN	_	13	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GR	gr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	binding	binding	NN	NN	_	6	nmod	_	_
14	contribute	contribute	VBP	VBP	_	4	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	poor	poor	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	asthma	asthma	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	29	29	CD	CD	_	3	nummod	_	_
2	asthma	asthma	NN	NN	_	3	compound	_	_
3	patients	patient	NNS	NNS	_	19	nsubjpass	_	_
4	with	with	IN	IN	_	7	case	_	_
5	forced	force	VBN	VBN	_	7	amod	_	_
6	expiratory	expiratory	JJ	JJ	_	7	amod	_	_
7	volume	volume	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	s	s	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	FEV1	fev1	NN	NN	_	7	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	&lt;	&lt;	JJR	JJR	_	15	advmod	_	_
15	70	70	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	7	dep	_	_
17	predicted	predict	VBN	VBN	_	7	acl	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	studied	study	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Patients	patient	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	classified	classify	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	steroid	steroid	NN	NN	_	6	nmod:npmod	_	_
6	sensitive	sensitive	JJ	JJ	_	3	advcl	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	SS	ss	JJ	JJ	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	if	if	IN	IN	_	14	mark	_	_
11	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
12	morning	morning	NN	NN	_	13	compound	_	_
13	FEV1	fev1	NN	NN	_	14	nsubj	_	_
14	increased	increase	VBD	VBD	_	3	advcl	_	_
15	&gt;	&gt;	RBR	RBR	_	16	advmod	_	_
16	30	30	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	14	dobj	_	_
18	after	after	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	1-wk	1-wk	JJ	JJ	_	21	amod	_	_
21	course	course	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	oral	oral	JJ	JJ	_	24	amod	_	_
24	prednisone	prednisone	NN	NN	_	21	nmod	_	_
25	20	20	CD	CD	_	26	nummod	_	_
26	mg	mg	NN	NN	_	24	dep	_	_
27	twice	twice	RB	RB	_	28	advmod	_	_
28	daily	daily	RB	RB	_	24	advmod	_	_
29	and	and	CC	CC	_	3	cc	_	_
30	steroid	steroid	NN	NN	_	31	nmod:npmod	_	_
31	resistant	resistant	JJ	JJ	_	3	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	SR	sr	JJ	JJ	_	31	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	if	if	IN	IN	_	37	mark	_	_
36	they	they	PRP	PRP	_	37	nsubj	_	_
37	failed	fail	VBD	VBD	_	31	advcl	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	increase	increase	VB	VB	_	37	xcomp	_	_
40	&gt;	&gt;	RBR	RBR	_	41	advmod	_	_
41	15	15	CD	CD	_	42	nummod	_	_
42	%	%	NN	NN	_	39	dobj	_	_
43	.	.	.	.	_	3	punct	_	_

1	PBMC	pbmc	NN	NN	_	21	nsubjpass	_	_
2	obtained	obtain	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	two	two	CD	CD	_	6	nummod	_	_
6	groups	group	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	17	17	CD	CD	_	9	nummod	_	_
9	SR	sr	JJ	JJ	_	6	appos	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	12	12	CD	CD	_	12	nummod	_	_
12	SS	ss	JJ	JJ	_	9	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	as	as	RB	RB	_	6	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	12	12	CD	CD	_	19	nummod	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	controls	control	NNS	NNS	_	6	conj	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	analyzed	analyze	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	SR	sr	JJ	JJ	_	2	amod	_	_
2	patients	patient	NNS	NNS	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	two	two	CD	CD	_	8	nummod	_	_
5	distinguishable	distinguishable	JJ	JJ	_	8	amod	_	_
6	GR	gr	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	abnormalities	abnormality	NNS	NNS	_	3	dobj	_	_
9	:	:	:	:	_	3	punct	_	_
10	15	15	CD	CD	_	16	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	17	17	CD	CD	_	15	nummod	_	_
14	SR	sr	JJ	JJ	_	15	amod	_	_
15	patients	patient	NNS	NNS	_	10	nmod	_	_
16	demonstrated	demonstrate	VBD	VBD	_	3	parataxis	_	_
17	a	a	DT	DT	_	22	det	_	_
18	significantly	significantly	RB	RB	_	19	advmod	_	_
19	reduced	reduce	VBN	VBN	_	22	amod	_	_
20	GR	gr	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	affinity	affinity	NN	NN	_	16	dobj	_	_
23	,	,	,	,	_	16	punct	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	compared	compare	VBN	VBN	_	16	advcl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	SS	ss	JJ	JJ	_	28	amod	_	_
28	patients	patient	NNS	NNS	_	25	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	P	p	NN	NN	_	31	nsubj	_	_
31	=	=	JJ	JJ	_	28	dep	_	_
32	0.0001	0.0001	CD	CD	_	31	dobj	_	_
33	)	)	-RRB-	-RRB-	_	31	punct	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	normal	normal	JJ	JJ	_	36	amod	_	_
36	controls	control	NNS	NNS	_	28	conj	_	_
37	(	(	-LRB-	-LRB-	_	39	punct	_	_
38	P	p	NN	NN	_	39	nsubj	_	_
39	=	=	JJ	JJ	_	36	dep	_	_
40	0.0001	0.0001	CD	CD	_	39	dobj	_	_
41	)	)	-RRB-	-RRB-	_	39	punct	_	_
42	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	defect	defect	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	aux	_	_
4	localized	localized	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	reverted	revert	VBD	VBD	_	4	conj	_	_
10	to	to	TO	TO	_	11	case	_	_
11	normal	normal	JJ	JJ	_	9	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	48	48	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	culture	culture	NN	NN	_	17	compound	_	_
17	media	media	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	incubation	incubation	NN	NN	_	11	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	combination	combination	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-2	il-2	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-4	il-4	NN	NN	_	8	conj	_	_
11	sustained	sustain	VBD	VBD	_	0	root	_	_
12	this	this	DT	DT	_	13	det	_	_
13	abnormality	abnormality	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	SR	sr	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	6	nsubj	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	an	a	DT	DT	_	11	det	_	_
8	abnormally	abnormally	RB	RB	_	9	advmod	_	_
9	low	low	JJ	JJ	_	11	amod	_	_
10	GR	gr	NN	NN	_	11	compound	_	_
11	number	number	NN	NN	_	6	dobj	_	_
12	with	with	IN	IN	_	15	case	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	affinity	affinity	NN	NN	_	11	nmod	_	_
16	that	that	WDT	WDT	_	19	nsubjpass	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	limited	limit	VBN	VBN	_	15	acl:relcl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	GR	gr	NN	NN	_	4	compound	_	_
4	number	number	NN	NN	_	5	nsubj	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	normalize	normalize	VB	VB	_	5	xcomp	_	_
8	after	after	IN	IN	_	9	case	_	_
9	incubation	incubation	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	media	media	NNS	NNS	_	9	nmod	_	_
12	alone	alone	RB	RB	_	11	advmod	_	_
13	or	or	CC	CC	_	11	cc	_	_
14	IL-2	il-2	NN	NN	_	11	conj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-4	il-4	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	SR	sr	JJ	JJ	_	4	amod	_	_
4	asthma	asthma	NN	NN	_	12	nsubj	_	_
5	may	may	MD	MD	_	12	aux	_	_
6	be	be	VB	VB	_	12	cop	_	_
7	due	due	JJ	JJ	_	12	case	_	_
8	to	to	TO	TO	_	7	mwe	_	_
9	more	more	JJR	JJR	_	11	advmod	_	_
10	than	than	IN	IN	_	9	mwe	_	_
11	one	one	CD	CD	_	12	nummod	_	_
12	abnormality	abnormality	NN	NN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	majority	majority	NN	NN	_	12	appos	_	_
16	related	related	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	reversible	reversible	JJ	JJ	_	21	amod	_	_
20	cytokine-induced	cytokine-induced	JJ	JJ	_	21	amod	_	_
21	reduction	reduction	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	GR	gr	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	affinity	affinity	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	the	the	DT	DT	_	28	det	_	_
28	second	second	JJ	JJ	_	15	conj	_	_
29	related	related	JJ	JJ	_	28	amod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	irreversible	irreversible	JJ	JJ	_	33	amod	_	_
33	reduction	reduction	NN	NN	_	29	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	GR	gr	NN	NN	_	36	compound	_	_
36	number	number	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	implications	implication	NNS	NNS	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	design	design	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	alternative	alternative	JJ	JJ	_	13	amod	_	_
12	treatment	treatment	NN	NN	_	13	compound	_	_
13	approaches	approach	NNS	NNS	_	9	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	recalcitrant	recalcitrant	JJ	JJ	_	16	amod	_	_
16	asthma	asthma	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Rhabdomyosarcomas	rhabdomyosarcoma	NNS	NNS	_	4	nsubj	_	_
2	do	do	VBP	VBP	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	contain	contain	VB	VB	_	0	root	_	_
5	mutations	mutation	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	domains	domain	NNS	NNS	_	4	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	myogenic	myogenic	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Skeletal	skeletal	JJ	JJ	_	2	amod	_	_
2	myogenesis	myogenesis	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	regulated	regulate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	group	group	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MyoD	myod	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	myogenin	myogenin	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	myf5	myf5	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	myf6	myf6	NN	NN	_	12	conj	_	_
20	)	)	-RRB-	-RRB-	_	12	punct	_	_
21	that	that	WDT	WDT	_	26	nsubj	_	_
22	are	be	VBP	VBP	_	26	cop	_	_
23	``	``	``	``	_	26	punct	_	_
24	basic	basic	JJ	JJ	_	26	amod	_	_
25	helix-loop-helix	helix-loop-helix	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	10	acl:relcl	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	bind	bind	VBP	VBP	_	26	acl:relcl	_	_
29	to	to	TO	TO	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	promoters	promoter	NNS	NNS	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	muscle-specific	muscle-specific	JJ	JJ	_	34	amod	_	_
34	genes	gene	NNS	NNS	_	31	nmod	_	_
35	and	and	CC	CC	_	28	cc	_	_
36	promote	promote	VBP	VBP	_	28	conj	_	_
37	their	they	PRP$	PRP$	_	38	nmod:poss	_	_
38	expression	expression	NN	NN	_	36	dobj	_	_
39	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	after	after	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	mutation	mutation	NN	NN	_	20	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Leu122	leu122	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	Arg	arg	NN	NN	_	8	nmod	_	_
13	the	the	DT	DT	_	17	det	_	_
14	DNA	dna	NN	NN	_	17	compound	_	_
15	binding	binding	NN	NN	_	17	compound	_	_
16	basic	basic	JJ	JJ	_	17	amod	_	_
17	domain	domain	NN	NN	_	20	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	MyoD	myod	NN	NN	_	17	nmod	_	_
20	confers	confer	VBZ	VBZ	_	4	ccomp	_	_
21	c-myc-like	c-myc-like	JJ	JJ	_	23	amod	_	_
22	functional	functional	JJ	JJ	_	23	amod	_	_
23	characteristics	characteristic	NNS	NNS	_	20	dobj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	protein	protein	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	used	use	VBD	VBD	_	0	root	_	_
6	single-strand	single-strand	JJ	JJ	_	9	amod	_	_
7	conformation	conformation	NN	NN	_	9	compound	_	_
8	polymorphism	polymorphism	NN	NN	_	9	compound	_	_
9	analysis	analysis	NN	NN	_	5	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	determine	determine	VB	VB	_	5	advcl	_	_
12	whether	whether	IN	IN	_	15	mark	_	_
13	such	such	JJ	JJ	_	14	amod	_	_
14	mutations	mutation	NNS	NNS	_	15	nsubj	_	_
15	occur	occur	VBP	VBP	_	11	ccomp	_	_
16	naturally	naturally	RB	RB	_	15	advmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	rhabdomyosarcomas	rhabdomyosarcoma	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	basic	basic	JJ	JJ	_	7	amod	_	_
7	domains	domain	NNS	NNS	_	13	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	all	all	PDT	PDT	_	12	det:predet	_	_
10	the	the	DT	DT	_	12	det	_	_
11	myogenic	myogenic	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	7	nmod	_	_
13	remain	remain	VBP	VBP	_	3	ccomp	_	_
14	unaltered	unaltered	JJ	JJ	_	13	xcomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	rhabdomyosarcomas	rhabdomyosarcoma	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Selection	selection	NN	NN	_	8	nsubj	_	_
2	against	against	IN	IN	_	4	case	_	_
3	such	such	JJ	JJ	_	4	amod	_	_
4	mutations	mutation	NNS	NNS	_	1	nmod	_	_
5	may	may	MD	MD	_	8	aux	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	the	the	DT	DT	_	8	det	_	_
8	result	result	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	redundancy	redundancy	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	these	these	DT	DT	_	16	det	_	_
14	myogenic	myogenic	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	proliferation	proliferation	NN	NN	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	cytotoxicity	cytotoxicity	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	2	conj	_	_
9	after	after	IN	IN	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
17	through	through	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	surface	surface	NN	NN	_	20	compound	_	_
20	ganglioside	ganglioside	NN	NN	_	10	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	GD3	gd3	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	-LSB-	-lsb-	-LRB-	-LRB-	_	27	punct	_	_
25	published	publish	VBN	VBN	_	26	amod	_	_
26	erratum	erratum	NN	NN	_	27	nsubj	_	_
27	appears	appear	VBZ	VBZ	_	2	dep	_	_
28	in	in	IN	IN	_	30	case	_	_
29	J	J	NNP	NNP	_	30	compound	_	_
30	Immunol	Immunol	NNP	NNP	_	27	nmod	_	_
31	1994	1994	CD	CD	_	32	nummod	_	_
32	Jul	Jul	NNP	NNP	_	30	dep	_	_
33	15	15	CD	CD	_	32	nummod	_	_
34	;	;	:	:	_	30	punct	_	_
35	153	153	CD	CD	_	37	nummod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	2	2	CD	CD	_	30	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	:	:	:	:	_	30	punct	_	_
40	910	910	CD	CD	_	30	dep	_	_
41	-RSB-	-rsb-	-RRB-	-RRB-	_	27	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	gangliosides	ganglioside	NNS	NNS	_	7	nsubj	_	_
7	have	have	VBP	VBP	_	4	ccomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cell	cell	NN	NN	_	7	nmod	_	_
13	signaling	signaling	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	recognition	recognition	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	their	they	PRP$	PRP$	_	5	nmod:poss	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	function	function	NN	NN	_	13	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	processes	process	NNS	NNS	_	5	nmod	_	_
9	has	have	VBZ	VBZ	_	13	aux	_	_
10	not	not	RB	RB	_	13	neg	_	_
11	been	be	VBN	VBN	_	13	auxpass	_	_
12	clearly	clearly	RB	RB	_	13	advmod	_	_
13	defined	define	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	mAb	mab	NN	NN	_	19	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	R24	r24	NN	NN	_	2	appos	_	_
5	,	,	,	,	_	2	punct	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	reacts	react	VBZ	VBZ	_	2	acl:relcl	_	_
8	specifically	specifically	RB	RB	_	7	advmod	_	_
9	with	with	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	ganglioside	ganglioside	NN	NN	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GD3	gd3	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	has	have	VBZ	VBZ	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	stimulate	stimulate	VB	VB	_	19	xcomp	_	_
22	proliferation	proliferation	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	derived	derive	VBN	VBN	_	25	acl	_	_
27	from	from	IN	IN	_	30	case	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	peripheral	peripheral	JJ	JJ	_	30	amod	_	_
30	blood	blood	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	investigated	investigate	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	mechanisms	mechanism	NNS	NNS	_	7	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	15	nmod	_	_
12	the	the	DT	DT	_	14	det	_	_
13	R24	r24	NN	NN	_	14	compound	_	_
14	mAb	mab	NN	NN	_	15	nsubj	_	_
15	affects	affect	VBZ	VBZ	_	9	acl:relcl	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	functions	function	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	observed	observe	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	R24	r24	NN	NN	_	7	compound	_	_
7	mAb	mab	NN	NN	_	8	nsubj	_	_
8	stimulates	stimulate	VBZ	VBZ	_	3	ccomp	_	_
9	GD3+	gd3+	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cell	cell	NN	NN	_	8	dobj	_	_
12	proliferation	proliferation	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	cytotoxicity	cytotoxicity	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	surface	surface	NN	NN	_	19	compound	_	_
18	marker	marker	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	12	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	IL-2R	il-2r	NN	NN	_	22	compound	_	_
22	alpha-chain	alpha-chain	NN	NN	_	11	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	IL-2R	il-2r	NN	NN	_	25	compound	_	_
25	beta-chain	beta-chain	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	HLA-DR	hla-dr	NN	NN	_	22	conj	_	_
28	,	,	,	,	_	22	punct	_	_
29	CD11a	cd11a	NN	NN	_	22	conj	_	_
30	,	,	,	,	_	22	punct	_	_
31	and	and	CC	CC	_	22	cc	_	_
32	CD11c	cd11c	NN	NN	_	22	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	Additionally	additionally	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	15	nsubj	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	4	cc	_	_
7	IL-1	il-1	NN	NN	_	13	compound	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-2	il-2	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	or	or	CC	CC	_	7	cc	_	_
12	IL-4	il-4	NN	NN	_	7	conj	_	_
13	activity	activity	NN	NN	_	4	conj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	present	present	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	culture	culture	NN	NN	_	18	compound	_	_
18	supernatants	supernatant	NNS	NNS	_	15	nmod	_	_
19	72	72	CD	CD	_	20	nummod	_	_
20	h	h	NN	NN	_	15	nmod	_	_
21	after	after	IN	IN	_	20	case	_	_
22	R24	r24	NN	NN	_	23	compound	_	_
23	stimulation	stimulation	NN	NN	_	20	dep	_	_
24	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	some	some	DT	DT	_	3	det	_	_
3	donors	donor	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	increased	increase	VBN	VBN	_	9	amod	_	_
6	IL-6	il-6	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	conj	_	_
9	activity	activity	NN	NN	_	12	nsubjpass	_	_
10	also	also	RB	RB	_	12	advmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	after	after	IN	IN	_	15	case	_	_
14	R24	r24	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	R24	r24	NN	NN	_	4	compound	_	_
4	treatment	treatment	NN	NN	_	5	nsubj	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	translocation	translocation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	c-rel	c-rel	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	9	cc	_	_
12	little	little	JJ	JJ	_	17	amod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	no	no	DT	DT	_	12	conj	_	_
15	NF	nf	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	9	conj	_	_
18	p50	p50	NN	NN	_	17	dep	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	p65	p65	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	9	punct	_	_
22	from	from	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cytoplasm	cytoplasm	NN	NN	_	7	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	nucleus	nucleus	NN	NN	_	7	nmod	_	_
28	and	and	CC	CC	_	7	cc	_	_
29	an	a	DT	DT	_	30	det	_	_
30	increase	increase	NN	NN	_	7	conj	_	_
31	of	of	IN	IN	_	36	case	_	_
32	NF	nf	NN	NN	_	35	dep	_	_
33	kappa	kappa	NN	NN	_	35	dep	_	_
34	B	b	NN	NN	_	35	dep	_	_
35	binding	binding	NN	NN	_	36	amod	_	_
36	complexes	complex	NNS	NNS	_	30	nmod	_	_
37	containing	contain	VBG	VBG	_	36	acl	_	_
38	c-rel	c-rel	NN	NN	_	37	dobj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	p50	p50	NN	NN	_	38	conj	_	_
41	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	treatment	treatment	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	caused	cause	VBD	VBD	_	0	root	_	_
5	increased	increase	VBN	VBN	_	7	amod	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	specific	specific	JJ	JJ	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	substrates	substrate	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	R24-stimulated	r24-stimulated	JJ	JJ	_	2	amod	_	_
2	increases	increase	NNS	NNS	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	proliferation	proliferation	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	cytotoxicity	cytotoxicity	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	cell	cell	NN	NN	_	12	compound	_	_
10	surface	surface	NN	NN	_	12	compound	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	4	conj	_	_
13	could	could	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	blocked	block	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	cyclosporin	cyclosporin	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	staurosporin	staurosporin	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	indicating	indicate	VBG	VBG	_	15	xcomp	_	_
22	that	that	IN	IN	_	30	mark	_	_
23	cyclophilin/calcineurin	cyclophilin/calcineurin	NN	NN	_	30	nsubjpass	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	protein	protein	NN	NN	_	27	compound	_	_
26	kinase	kinase	NN	NN	_	27	compound	_	_
27	C	c	NN	NN	_	23	conj	_	_
28	may	may	MD	MD	_	30	aux	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	involved	involve	VBN	VBN	_	21	ccomp	_	_
31	in	in	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	R24	r24	NN	NN	_	35	compound	_	_
34	signaling	signaling	NN	NN	_	35	compound	_	_
35	pathway	pathway	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	Additionally	additionally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	herbimycin	herbimycin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	11	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	4	appos	_	_
10	,	,	,	,	_	4	punct	_	_
11	blocked	block	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	R24-stimulated	r24-stimulated	JJ	JJ	_	14	amod	_	_
14	increase	increase	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	proliferation	proliferation	NN	NN	_	14	nmod	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	cytotoxicity	cytotoxicity	NN	NN	_	16	conj	_	_
20	at	at	IN	IN	_	21	case	_	_
21	concentrations	concentration	NNS	NNS	_	11	nmod	_	_
22	consistent	consistent	JJ	JJ	_	21	amod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	specificity	specificity	NN	NN	_	22	nmod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	tyrosine	tyrosine	NN	NN	_	27	compound	_	_
27	kinases	kinase	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	multiple	multiple	JJ	JJ	_	7	amod	_	_
6	biochemical	biochemical	JJ	JJ	_	7	amod	_	_
7	pathways	pathway	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	R24	r24	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	SCL	scl	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	displays	display	VBZ	VBZ	_	0	root	_	_
5	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
6	heterogeneity	heterogeneity	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	size	size	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	SCL	scl	NN	NN	_	3	compound	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	production	production	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	variety	variety	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	hemopoietic	hemopoietic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	immunoblotting	immunoblot	VBG	VBG	_	5	nmod	_	_
15	using	use	VBG	VBG	_	14	acl	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	polyclonal	polyclonal	JJ	JJ	_	18	amod	_	_
18	antisera	antisera	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	SCL	scl	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	15	case	_	_
6	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	megakaryocyte	megakaryocyte	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	mast	mast	NN	NN	_	6	conj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	early	early	JJ	JJ	_	13	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	6	conj	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	4	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	as	as	RB	RB	_	15	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	in	in	IN	IN	_	25	case	_	_
21	several	several	JJ	JJ	_	25	amod	_	_
22	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
23	leukemia	leukemia	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	15	conj	_	_
26	which	which	WDT	WDT	_	28	nsubjpass	_	_
27	are	be	VBP	VBP	_	28	auxpass	_	_
28	known	know	VBN	VBN	_	25	acl:relcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	harbor	harbor	VB	VB	_	28	xcomp	_	_
31	SCL	scl	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	rearrangements	rearrangement	NNS	NNS	_	30	dobj	_	_
34	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	most	most	JJS	JJS	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	15	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	proteins	protein	NNS	NNS	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	weight	weight	NN	NN	_	6	nmod	_	_
10	49	49	CD	CD	_	13	nummod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	44	44	CD	CD	_	10	conj	_	_
13	kDa	kda	NN	NN	_	9	dep	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	however	however	RB	RB	_	22	advmod	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	22	nsubj	_	_
22	expressed	express	VBD	VBD	_	15	parataxis	_	_
23	only	only	RB	RB	_	27	advmod	_	_
24	lower	lower	JJR	JJR	_	27	amod	_	_
25	molecular	molecular	JJ	JJ	_	27	amod	_	_
26	weight	weight	NN	NN	_	27	compound	_	_
27	species	species	NNS	NNS	_	22	dobj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	24	24	CD	CD	_	32	nummod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	22	22	CD	CD	_	29	conj	_	_
32	kDa	kda	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	size	size	NN	NN	_	3	compound	_	_
3	discrepancy	discrepancy	NN	NN	_	4	nsubj	_	_
4	appeared	appear	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	11	mark	_	_
6	be	be	VB	VB	_	11	cop	_	_
7	due	due	JJ	JJ	_	11	case	_	_
8	to	to	TO	TO	_	7	mwe	_	_
9	cell-specific	cell-specific	JJ	JJ	_	11	amod	_	_
10	translational	translational	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	4	xcomp	_	_
12	,	,	,	,	_	4	punct	_	_
13	since	since	IN	IN	_	21	mark	_	_
14	overexpression	overexpression	NN	NN	_	21	nsubj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	a	a	DT	DT	_	20	det	_	_
17	retrovirally	retrovirally	RB	RB	_	18	advmod	_	_
18	transfected	transfect	VBN	VBN	_	20	amod	_	_
19	SCL	scl	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	14	nmod	_	_
21	yielded	yield	VBD	VBD	_	4	advcl	_	_
22	the	the	DT	DT	_	26	det	_	_
23	higher	higher	JJR	JJR	_	26	amod	_	_
24	molecular	molecular	JJ	JJ	_	26	amod	_	_
25	weight	weight	NN	NN	_	26	compound	_	_
26	forms	form	NNS	NNS	_	21	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	most	most	JJS	JJS	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	21	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	GP+E-86	gp+e-86	NN	NN	_	30	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	AT2.5	at2.5	NN	NN	_	32	appos	_	_
35	,	,	,	,	_	32	punct	_	_
36	M1	m1	NN	NN	_	32	appos	_	_
37	)	)	-RRB-	-RRB-	_	32	punct	_	_
38	but	but	CC	CC	_	21	cc	_	_
39	only	only	RB	RB	_	43	advmod	_	_
40	the	the	DT	DT	_	43	det	_	_
41	22	22	CD	CD	_	42	compound	_	_
42	kDa	kda	NN	NN	_	43	amod	_	_
43	form	form	NN	NN	_	21	conj	_	_
44	in	in	IN	IN	_	48	case	_	_
45	the	the	DT	DT	_	48	det	_	_
46	myeloid	myeloid	JJ	JJ	_	48	amod	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	line	line	NN	NN	_	43	nmod	_	_
49	,	,	,	,	_	48	punct	_	_
50	WEHI-3B/D+	wehi-3b/d+	NN	NN	_	48	appos	_	_
51	.	.	.	.	_	4	punct	_	_

1	Overexpression	overexpression	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	full-length	full-length	JJ	JJ	_	5	amod	_	_
4	SCL	scl	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	lymphoid	lymphoid	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	SupT1	supt1	NN	NN	_	10	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Raji	raji	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	alter	alter	VB	VB	_	0	root	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	phenotype	phenotype	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	there	there	EX	EX	_	23	expl	_	_
23	was	be	VBD	VBD	_	18	conj	_	_
24	no	no	DT	DT	_	25	neg	_	_
25	evidence	evidence	NN	NN	_	23	nsubj	_	_
26	for	for	IN	IN	_	27	case	_	_
27	autoregulation	autoregulation	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	SCL	scl	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	restricted	restricted	JJ	JJ	_	3	amod	_	_
3	pattern	pattern	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	SCL	scl	NN	NN	_	7	compound	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	consistent	consistent	JJ	JJ	_	0	root	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	restricted	restricted	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	SCL	scl	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	13	nmod	_	_
17	documented	document	VBN	VBN	_	13	acl	_	_
18	previously	previously	RB	RB	_	17	advmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	results	result	NNS	NNS	_	7	nsubj	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	SCL	scl	NN	NN	_	11	compound	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	size	size	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	determined	determine	VBN	VBN	_	7	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	regulation	regulation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	translation	translation	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	cell-specific	cell-specific	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Activation	activation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	7	amod	_	_
5	colony-stimulating	colony-stimulating	JJ	JJ	_	7	amod	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	requires	require	VBZ	VBZ	_	0	root	_	_
12	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
13	binding	binding	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	Elf-1	elf-1	NN	NN	_	19	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	AP-1	ap-1	NN	NN	_	15	conj	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	4	amod	_	_
3	colony-stimulating	colony-stimulating	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GM-CSF	gm-csf	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	gene	gene	NN	NN	_	11	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	studied	study	VBN	VBN	_	0	root	_	_
12	extensively	extensively	RB	RB	_	11	advmod	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	model	model	NN	NN	_	16	compound	_	_
16	system	system	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	induction	induction	NN	NN	_	16	nmod	_	_
20	during	during	IN	IN	_	22	case	_	_
21	T-lymphocyte	t-lymphocyte	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GM-CSF	gm-csf	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	12	case	_	_
8	resting	rest	VBG	VBG	_	12	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	but	but	CC	CC	_	6	cc	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	rapidly	rapidly	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	6	conj	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	following	follow	VBG	VBG	_	22	case	_	_
22	activation	activation	NN	NN	_	16	nmod	_	_
23	through	through	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	cell	cell	NN	NN	_	28	compound	_	_
26	surface	surface	NN	NN	_	28	compound	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	16	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	highly	highly	RB	RB	_	3	advmod	_	_
3	conserved	conserve	VBN	VBN	_	5	amod	_	_
4	19-bp	19-bp	JJ	JJ	_	5	amod	_	_
5	element	element	NN	NN	_	33	nsubjpass	_	_
6	located	located	JJ	JJ	_	5	amod	_	_
7	immediately	immediately	RB	RB	_	6	advmod	_	_
8	5'	5'	JJ	JJ	_	7	nmod:npmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	GM-CSF	gm-csf	NN	NN	_	14	compound	_	_
13	TATA	tata	NN	NN	_	14	compound	_	_
14	box	box	NN	NN	_	8	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	bp	bp	NN	NN	_	8	dep	_	_
17	-34	-34	CD	CD	_	16	nmod	_	_
18	to	to	TO	TO	_	17	case	_	_
19	-52	-52	CD	CD	_	17	dep	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	,	,	,	,	_	5	punct	_	_
22	herein	herein	RB	RB	_	23	advmod	_	_
23	called	call	VBN	VBN	_	5	acl	_	_
24	purine	purine	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	23	xcomp	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PB1	pb1	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	5	punct	_	_
31	has	have	VBZ	VBZ	_	33	aux	_	_
32	been	be	VBN	VBN	_	33	auxpass	_	_
33	shown	show	VBN	VBN	_	0	root	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	bind	bind	VB	VB	_	33	ccomp	_	_
36	a	a	DT	DT	_	40	det	_	_
37	T-cell	t-cell	NN	NN	_	40	compound	_	_
38	nuclear	nuclear	JJ	JJ	_	40	amod	_	_
39	protein	protein	NN	NN	_	40	compound	_	_
40	complex	complex	NN	NN	_	35	dobj	_	_
41	and	and	CC	CC	_	35	cc	_	_
42	to	to	TO	TO	_	44	mark	_	_
43	be	be	VB	VB	_	44	auxpass	_	_
44	required	require	VBN	VBN	_	35	conj	_	_
45	for	for	IN	IN	_	47	case	_	_
46	transcriptional	transcriptional	JJ	JJ	_	47	amod	_	_
47	induction	induction	NN	NN	_	44	nmod	_	_
48	of	of	IN	IN	_	51	case	_	_
49	the	the	DT	DT	_	51	det	_	_
50	GM-CSF	gm-csf	NN	NN	_	51	compound	_	_
51	gene	gene	NN	NN	_	47	nmod	_	_
52	following	follow	VBG	VBG	_	54	case	_	_
53	T-cell	t-cell	NN	NN	_	54	compound	_	_
54	activation	activation	NN	NN	_	47	nmod	_	_
55	.	.	.	.	_	33	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	PB1	pb1	NN	NN	_	4	compound	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	motif	motif	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	conserved	conserve	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	14	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	murine	murine	JJ	JJ	_	10	conj	_	_
13	GM-CSF	gm-csf	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	PB1	pb1	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	12	nsubj	_	_
11	alone	alone	RB	RB	_	10	advmod	_	_
12	confers	confer	VBZ	VBZ	_	6	ccomp	_	_
13	inducibility	inducibility	NN	NN	_	12	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	following	follow	VBG	VBG	_	19	case	_	_
19	transfection	transfection	NN	NN	_	12	nmod	_	_
20	into	into	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	Jurkat	jurkat	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	identify	identify	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	11	det	_	_
7	major	major	JJ	JJ	_	11	amod	_	_
8	PB1	pb1	NN	NN	_	11	compound	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	protein-binding	protein-binding	JJ	JJ	_	11	amod	_	_
11	complex	complex	NN	NN	_	5	dobj	_	_
12	that	that	WDT	WDT	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	present	present	JJ	JJ	_	11	acl:relcl	_	_
16	in	in	IN	IN	_	21	case	_	_
17	resting	rest	VBG	VBG	_	21	amod	_	_
18	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
19	blood	blood	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	but	but	CC	CC	_	15	cc	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	rapidly	rapidly	RB	RB	_	25	advmod	_	_
25	induced	induce	VBN	VBN	_	15	conj	_	_
26	following	follow	VBG	VBG	_	28	case	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PB1	pb1	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	composed	compose	VBN	VBN	_	3	ccomp	_	_
8	of	of	IN	IN	_	11	case	_	_
9	adjacent	adjacent	JJ	JJ	_	11	amod	_	_
10	binding	bind	VBG	VBG	_	11	amod	_	_
11	sites	site	NNS	NNS	_	7	nmod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	Ets	ets	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	13	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	mutagenesis	mutagenesis	NN	NN	_	4	compound	_	_
4	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	both	both	CC	CC	_	9	cc:preconj	_	_
8	the	the	DT	DT	_	9	det	_	_
9	Ets	et	NNS	NNS	_	14	nsubjpass	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	AP-1	ap-1	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	9	conj	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	5	ccomp	_	_
15	for	for	IN	IN	_	16	case	_	_
16	binding	binding	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	inducible	inducible	JJ	JJ	_	23	amod	_	_
20	PB1	pb1	NN	NN	_	23	compound	_	_
21	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	16	nmod	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	for	for	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	activity	activity	NN	NN	_	16	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	element	element	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	35	det	_	_
34	GM-CSF	gm-csf	NN	NN	_	35	compound	_	_
35	promoter	promoter	NN	NN	_	31	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	activated	activate	VBN	VBN	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	16	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	BZLF1	bzlf1	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	second	second	JJ	JJ	_	11	amod	_	_
11	messengers	messenger	NNS	NNS	_	1	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	anti-immunoglobulin-treated	anti-immunoglobulin-treated	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Initiation	initiation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
5	virus	virus	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EBV	ebv	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	lytic	lytic	JJ	JJ	_	10	amod	_	_
10	cycle	cycle	NN	NN	_	1	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	BZLF1	bzlf1	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	BZLF1	bzlf1	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Zp	zp	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	crosslinking	crosslinking	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	surface	surface	NN	NN	_	11	nmod	_	_
15	immunoglobulin	immunoglobulin	NN	NN	_	14	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Ig	ig	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	anti-Ig	anti-ig	JJ	JJ	_	21	amod	_	_
21	antibody	antibody	NN	NN	_	11	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	9	nmod	_	_
25	,	,	,	,	_	9	punct	_	_
26	even	even	RB	RB	_	33	advmod	_	_
27	in	in	IN	IN	_	33	case	_	_
28	the	the	DT	DT	_	33	dep	_	_
29	absence	absence	NN	NN	_	33	dep	_	_
30	of	of	IN	IN	_	33	case	_	_
31	other	other	JJ	JJ	_	33	amod	_	_
32	viral	viral	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	9	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	several	several	JJ	JJ	_	6	amod	_	_
4	anti-Ig	anti-ig	JJ	JJ	_	6	amod	_	_
5	response	response	NN	NN	_	6	compound	_	_
6	elements	element	NNS	NNS	_	2	dobj	_	_
7	within	within	IN	IN	_	8	case	_	_
8	Zp	zp	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	originally	originally	RB	RB	_	13	advmod	_	_
13	defined	define	VBN	VBN	_	6	acl:relcl	_	_
14	as	as	IN	IN	_	20	case	_	_
15	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TPA	tpa	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	13	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	ZI	zi	NN	NN	_	23	compound	_	_
23	repeats	repeat	NNS	NNS	_	20	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	ZII	zii	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	25	punct	_	_
27	an	a	DT	DT	_	29	det	_	_
28	AP-1-like	ap-1-like	JJ	JJ	_	29	amod	_	_
29	domain	domain	NN	NN	_	25	appos	_	_
30	)	)	-RRB-	-RRB-	_	23	punct	_	_
31	.	.	.	.	_	2	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	anti-Ig	anti-ig	JJ	JJ	_	3	amod	_	_
3	crosslinking	crosslinking	NN	NN	_	4	nsubj	_	_
4	leads	lead	VBZ	VBZ	_	24	advcl	_	_
5	to	to	TO	TO	_	6	case	_	_
6	activation	activation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PKC	pkc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	an	a	DT	DT	_	16	det	_	_
16	increase	increase	NN	NN	_	6	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	24	punct	_	_
22	Zp	zp	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	tested	test	VBN	VBN	_	0	root	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	response	response	NN	NN	_	24	nmod	_	_
28	to	to	TO	TO	_	31	case	_	_
29	these	these	DT	DT	_	31	det	_	_
30	cellular	cellular	JJ	JJ	_	31	amod	_	_
31	factors	factor	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	24	punct	_	_

1	Treatment	treatment	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	calcium	calcium	NN	NN	_	5	compound	_	_
4	ionophore	ionophore	NN	NN	_	5	compound	_	_
5	A23187	a23187	NN	NN	_	1	nmod	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	Zp	zp	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	.	.	.	.	_	6	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	calcium	calcium	NN	NN	_	4	compound	_	_
4	ionophore	ionophore	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	21	advcl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	conjunction	conjunction	NN	NN	_	10	dep	_	_
9	with	with	IN	IN	_	10	case	_	_
10	TPA	tpa	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	PKC	pkc	NN	NN	_	14	compound	_	_
14	activator	activator	NN	NN	_	10	appos	_	_
15	,	,	,	,	_	21	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	Zp	zp	NN	NN	_	18	compound	_	_
18	induction	induction	NN	NN	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	synergistically	synergistically	RB	RB	_	21	advmod	_	_
21	enhanced	enhance	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	1-(5-isoquinolinylsulfonyl)-2-methylpiperazine	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PKC	pkc	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	anti-Ig	anti-ig	JJ	JJ	_	11	amod	_	_
11	inducibility	inducibility	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Zp	zp	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Calmodulin	calmodulin	NN	NN	_	2	compound	_	_
2	antagonists	antagonist	NNS	NNS	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	compound	compound	NN	NN	_	5	compound	_	_
5	R24571	r24571	NN	NN	_	2	appos	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	trifluoperazine	trifluoperazine	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	2	punct	_	_
9	blocked	block	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Zp	zp	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	dobj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	anti-Ig	anti-ig	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Zp	zp	NN	NN	_	6	nsubj	_	_
6	responds	respond	VBZ	VBZ	_	3	ccomp	_	_
7	directly	directly	RB	RB	_	6	advmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	changes	change	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	PKC	pkc	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	calcium/calmodulin-dependent	calcium/calmodulin-dependent	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Requirement	requirement	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	anti-Ig-mediated	anti-ig-mediated	JJ	JJ	_	10	amod	_	_
9	Zp	zp	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	1	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
14	through	through	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	use	use	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
20	kinase	kinase	NN	NN	_	22	compound	_	_
21	inhibitor	inhibitor	NN	NN	_	22	compound	_	_
22	herbimycin	herbimycin	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	5	det	_	_
2	cellular	cellular	JJ	JJ	_	5	amod	_	_
3	gene	gene	NN	NN	_	5	compound	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	molecules	molecule	NNS	NNS	_	11	nsubj	_	_
6	induced	induce	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	anti-Ig	anti-ig	NN	NN	_	6	nmod	_	_
9	may	may	MD	MD	_	11	aux	_	_
10	cooperatively	cooperatively	RB	RB	_	11	advmod	_	_
11	play	play	VB	VB	_	0	root	_	_
12	an	a	DT	DT	_	14	det	_	_
13	important	important	JJ	JJ	_	14	amod	_	_
14	part	part	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	achieving	achieve	VBG	VBG	_	11	advcl	_	_
17	efficient	efficient	JJ	JJ	_	19	amod	_	_
18	EBV	ebv	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	16	dobj	_	_
20	as	as	IN	IN	_	21	mark	_	_
21	seen	see	VBN	VBN	_	11	advcl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	anti-Ig	anti-ig	JJ	JJ	_	24	amod	_	_
24	treatment	treatment	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	downmodulates	downmodulate	VBZ	VBZ	_	0	root	_	_
4	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	GATA1	gata1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	purified	purify	VBN	VBN	_	12	amod	_	_
11	adult-progenitor	adult-progenitor	JJ	JJ	_	12	amod	_	_
12	culture	culture	NN	NN	_	5	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	All-trans	all-trans	JJ	JJ	_	3	amod	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	RA	ra	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	morphogen	morphogen	NN	NN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	vertebrate	vertebrate	NN	NN	_	13	compound	_	_
13	development	development	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	normal	normal	JJ	JJ	_	17	amod	_	_
17	constituent	constituent	NN	NN	_	10	appos	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	adult	adult	JJ	JJ	_	21	amod	_	_
21	blood	blood	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	is	be	VBZ	VBZ	_	25	aux	_	_
24	also	also	RB	RB	_	25	advmod	_	_
25	involved	involve	VBN	VBN	_	10	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	control	control	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	cell	cell	NN	NN	_	28	nmod	_	_
31	growth	growth	NN	NN	_	30	dep	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	differentiation	differentiation	NN	NN	_	31	conj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	acute	acute	JJ	JJ	_	37	amod	_	_
36	promyelocytic	promyelocytic	JJ	JJ	_	37	amod	_	_
37	leukemia	leukemia	NN	NN	_	30	nmod	_	_
38	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	RA	ra	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	hematopoiesis	hematopoiesis	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	using	use	VBG	VBG	_	3	advcl	_	_
13	early	early	JJ	JJ	_	16	amod	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	16	amod	_	_
15	progenitor	progenitor	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	dobj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HPC	hpc	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	stringently	stringently	RB	RB	_	21	advmod	_	_
21	purified	purify	VBN	VBN	_	16	acl	_	_
22	from	from	IN	IN	_	25	case	_	_
23	adult	adult	JJ	JJ	_	25	amod	_	_
24	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
25	blood	blood	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	14	case	_	_
2	clonogenetic	clonogenetic	JJ	JJ	_	14	amod	_	_
3	fetal	fetal	JJ	JJ	_	5	amod	_	_
4	calf	calf	NN	NN	_	5	nmod:npmod	_	_
5	serum-supplemented	serum-supplemented	JJ	JJ	_	14	amod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	FCS+	fcs+	JJ	JJ	_	5	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	or	or	CC	CC	_	5	cc	_	_
10	-nonsupplemented	-nonsupplemented	JJ	JJ	_	5	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	FCS-	fcs-	JJ	JJ	_	10	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	culture	culture	NN	NN	_	46	nmod	_	_
15	treated	treat	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	saturating	saturating	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	interleukin-3	interleukin-3	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IL-3	il-3	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	26	amod	_	_
25	colony-stimulating	colony-stimulating	JJ	JJ	_	26	amod	_	_
26	factor	factor	NN	NN	_	20	dep	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	GM-CSF	gm-csf	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	20	cc	_	_
31	erythropoietin	erythropoietin	NN	NN	_	20	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	Ep	ep	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	(	(	-LRB-	-LRB-	_	31	punct	_	_
36	combined	combine	VBN	VBN	_	39	case	_	_
37	with	with	IN	IN	_	39	case	_	_
38	c-kit	c-kit	NN	NN	_	39	compound	_	_
39	ligand	ligand	NN	NN	_	31	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	FCS(-)-culture	fcs(-)-culture	JJ	JJ	_	42	amod	_	_
42	conditions	condition	NNS	NNS	_	39	nmod	_	_
43	)	)	-RRB-	-RRB-	_	31	punct	_	_
44	,	,	,	,	_	46	punct	_	_
45	RA	ra	NN	NN	_	46	nsubj	_	_
46	induces	induce	VBZ	VBZ	_	0	root	_	_
47	a	a	DT	DT	_	50	det	_	_
48	dramatic	dramatic	JJ	JJ	_	50	amod	_	_
49	dose-dependent	dose-dependent	JJ	JJ	_	50	amod	_	_
50	shift	shift	NN	NN	_	46	dobj	_	_
51	from	from	IN	IN	_	52	case	_	_
52	erythroid	erythroid	JJ	JJ	_	50	nmod	_	_
53	to	to	TO	TO	_	54	case	_	_
54	granulomonocytic	granulomonocytic	JJ	JJ	_	50	nmod	_	_
55	colony	colony	NN	NN	_	56	compound	_	_
56	formation	formation	NN	NN	_	50	dep	_	_
57	,	,	,	,	_	46	punct	_	_
58	the	the	DT	DT	_	60	det	_	_
59	latter	latter	JJ	JJ	_	60	amod	_	_
60	colonies	colony	NNS	NNS	_	63	nsubjpass	_	_
61	being	be	VBG	VBG	_	63	auxpass	_	_
62	essentially	essentially	RB	RB	_	63	advmod	_	_
63	represented	represent	VBN	VBN	_	46	advcl	_	_
64	by	by	IN	IN	_	66	case	_	_
65	granulocytic	granulocytic	JJ	JJ	_	66	amod	_	_
66	clones	clone	NNS	NNS	_	63	nmod	_	_
67	.	.	.	.	_	46	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	shift	shift	NN	NN	_	6	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	6	auxpass	_	_
4	apparently	apparently	RB	RB	_	6	advmod	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	caused	cause	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	recruitment	recruitment	NN	NN	_	10	compound	_	_
10	phenomenon	phenomenon	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	because	because	IN	IN	_	25	mark	_	_
13	in	in	IN	IN	_	15	case	_	_
14	FCS+	fcs+	JJ	JJ	_	15	amod	_	_
15	culture	culture	NN	NN	_	25	nmod	_	_
16	,	,	,	,	_	25	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	total	total	JJ	JJ	_	19	amod	_	_
19	number	number	NN	NN	_	25	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	colonies	colony	NNS	NNS	_	19	nmod	_	_
22	is	be	VBZ	VBZ	_	25	auxpass	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	significantly	significantly	RB	RB	_	25	advmod	_	_
25	modified	modify	VBN	VBN	_	6	advcl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	RA	ra	NN	NN	_	28	compound	_	_
28	addition	addition	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	FCS-	fcs-	JJ	JJ	_	4	amod	_	_
3	liquid-suspension	liquid-suspension	NN	NN	_	4	compound	_	_
4	culture	culture	NN	NN	_	16	nmod	_	_
5	supplemented	supplement	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	saturating	saturating	JJ	JJ	_	9	amod	_	_
8	Ep	ep	NN	NN	_	9	compound	_	_
9	level	level	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	low-dose	low-dose	JJ	JJ	_	12	amod	_	_
12	IL-3/GM-CSF	il-3/gm-csf	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	16	punct	_	_
14	adult	adult	JJ	JJ	_	15	amod	_	_
15	HPC	hpc	NN	NN	_	16	nsubj	_	_
16	undergo	undergo	VBP	VBP	_	0	root	_	_
17	unilineage	unilineage	JJ	JJ	_	19	amod	_	_
18	erythropoietic	erythropoietic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	16	dobj	_	_
20	:	:	:	:	_	16	punct	_	_
21	Here	here	RB	RB	_	28	advmod	_	_
22	again	again	RB	RB	_	28	advmod	_	_
23	,	,	,	,	_	28	punct	_	_
24	treatment	treatment	NN	NN	_	28	nsubj	_	_
25	with	with	IN	IN	_	27	case	_	_
26	high-dose	high-dose	JJ	JJ	_	27	amod	_	_
27	RA	ra	NN	NN	_	24	nmod	_	_
28	induces	induce	VBZ	VBZ	_	16	parataxis	_	_
29	a	a	DT	DT	_	30	det	_	_
30	shift	shift	NN	NN	_	28	dobj	_	_
31	from	from	IN	IN	_	37	case	_	_
32	the	the	DT	DT	_	37	det	_	_
33	erythroid	erythroid	JJ	JJ	_	37	amod	_	_
34	to	to	TO	TO	_	33	dep	_	_
35	granulocytic	granulocytic	JJ	JJ	_	33	dep	_	_
36	differentiation	differentiation	NN	NN	_	37	compound	_	_
37	pathway	pathway	NN	NN	_	30	nmod	_	_
38	.	.	.	.	_	28	punct	_	_

1	Studies	study	NNS	NNS	_	13	nsubj	_	_
2	on	on	IN	IN	_	7	case	_	_
3	RA	ra	NN	NN	_	7	compound	_	_
4	time-response	time-response	JJ	JJ	_	7	amod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	pulse	pulse	NN	NN	_	4	conj	_	_
7	treatment	treatment	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	semisolid	semisolid	JJ	JJ	_	12	amod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	liquid	liquid	JJ	JJ	_	9	conj	_	_
12	culture	culture	NN	NN	_	7	nmod	_	_
13	show	show	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	RA	ra	NN	NN	_	17	compound	_	_
17	addition	addition	NN	NN	_	20	nsubj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	most	most	RBS	RBS	_	20	advmod	_	_
20	effective	effective	JJ	JJ	_	13	ccomp	_	_
21	,	,	,	,	_	13	punct	_	_
22	thus	thus	RB	RB	_	23	advmod	_	_
23	indicating	indicate	VBG	VBG	_	13	xcomp	_	_
24	that	that	IN	IN	_	31	mark	_	_
25	early	early	JJ	JJ	_	29	amod	_	_
26	but	but	CC	CC	_	25	cc	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	late	late	JJ	JJ	_	25	conj	_	_
29	HPC	hpc	NN	NN	_	31	nsubj	_	_
30	are	be	VBP	VBP	_	31	cop	_	_
31	sensitive	sensitive	JJ	JJ	_	23	ccomp	_	_
32	to	to	TO	TO	_	34	case	_	_
33	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
34	action	action	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	then	then	RB	RB	_	3	advmod	_	_
3	analyzed	analyze	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	master	master	NN	NN	_	10	compound	_	_
9	GATA1	gata1	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	encodes	encode	VBZ	VBZ	_	10	acl:relcl	_	_
14	a	a	DT	DT	_	17	det	_	_
15	finger	finger	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	dobj	_	_
18	required	require	VBN	VBN	_	17	acl	_	_
19	for	for	IN	IN	_	22	case	_	_
20	normal	normal	JJ	JJ	_	22	amod	_	_
21	erythroid	erythroid	JJ	JJ	_	22	amod	_	_
22	development	development	NN	NN	_	18	nmod	_	_
23	;	;	:	:	_	3	punct	_	_
24	addition	addition	NN	NN	_	37	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	RA	ra	NN	NN	_	24	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	HPC	hpc	NN	NN	_	24	nmod	_	_
29	stimulated	stimulate	VBN	VBN	_	28	acl	_	_
30	into	into	IN	IN	_	33	case	_	_
31	unilineage	unilineage	JJ	JJ	_	33	amod	_	_
32	erythropoietic	erythropoietic	JJ	JJ	_	33	amod	_	_
33	differentiation	differentiation	NN	NN	_	29	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	liquid	liquid	JJ	JJ	_	36	amod	_	_
36	culture	culture	NN	NN	_	29	nmod	_	_
37	caused	cause	VBD	VBD	_	3	parataxis	_	_
38	a	a	DT	DT	_	41	det	_	_
39	virtually	virtually	RB	RB	_	40	advmod	_	_
40	complete	complete	JJ	JJ	_	41	amod	_	_
41	inhibition	inhibition	NN	NN	_	37	dobj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	GATA1	gata1	NN	NN	_	45	compound	_	_
44	mRNA	mrna	NN	NN	_	45	compound	_	_
45	induction	induction	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	37	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	RA	ra	NN	NN	_	7	nsubj	_	_
6	directly	directly	RB	RB	_	7	advmod	_	_
7	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
10	differentiation	differentiation	NN	NN	_	11	compound	_	_
11	program	program	NN	NN	_	7	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	early	early	JJ	JJ	_	18	amod	_	_
17	adult	adult	JJ	JJ	_	18	amod	_	_
18	HPC	hpc	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	lead	lead	VB	VB	_	7	conj	_	_
23	to	to	TO	TO	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	shift	shift	NN	NN	_	22	nmod	_	_
26	from	from	IN	IN	_	32	case	_	_
27	the	the	DT	DT	_	32	det	_	_
28	erythroid	erythroid	JJ	JJ	_	32	amod	_	_
29	to	to	TO	TO	_	28	dep	_	_
30	granulocytic	granulocytic	JJ	JJ	_	28	dep	_	_
31	differentiation	differentiation	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenomenon	phenomenon	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	correlated	correlate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	inhibition	inhibition	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	GATA1	gata1	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	early	early	JJ	JJ	_	13	amod	_	_
13	stages	stage	NNS	NNS	_	6	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	erythropoietic	erythropoietic	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD45	cd45	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Implications	implication	NNS	NNS	_	0	root	_	_
2	for	for	IN	IN	_	3	case	_	_
3	replication	replication	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HIV-1	hiv-1	NN	NN	_	3	nmod	_	_
6	.	.	.	.	_	1	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	levels	level	NNS	NNS	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	replication	replication	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	4	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	after	after	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	infected	infected	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	through	through	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	TCR	tcr	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	anti-CD45	anti-cd45	JJ	JJ	_	4	amod	_	_
4	antibodies	antibody	NNS	NNS	_	5	nsubj	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	these	these	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	infected	infected	JJ	JJ	_	12	amod	_	_
12	individuals	individual	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	interrelationships	interrelationship	NNS	NNS	_	6	dobj	_	_
8	between	between	IN	IN	_	9	case	_	_
9	CD45	cd45	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	HIV-1	hiv-1	NN	NN	_	9	conj	_	_
12	further	further	RB	RB	_	6	advmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	effects	effect	NNS	NNS	_	2	dobj	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	LTR	ltr	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	3	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	stimulated	stimulate	VBN	VBN	_	11	acl:relcl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	antibodies	antibody	NNS	NNS	_	14	nmod	_	_
17	against	against	IN	IN	_	18	case	_	_
18	CD45	cd45	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	in	in	IN	IN	_	21	case	_	_
21	those	those	DT	DT	_	11	conj	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	lacked	lack	VBD	VBD	_	21	acl:relcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	CD45	cd45	NN	NN	_	25	nmod	_	_
28	on	on	IN	IN	_	30	case	_	_
29	their	they	PRP$	PRP$	_	30	nmod:poss	_	_
30	surfaces	surface	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	First	first	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	anti-CD45	anti-cd45	JJ	JJ	_	4	amod	_	_
4	antibodies	antibody	NNS	NNS	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	affect	affect	VB	VB	_	0	root	_	_
8	basal	basal	JJ	JJ	_	7	dobj	_	_
9	but	but	CC	CC	_	7	cc	_	_
10	decreased	decrease	VBD	VBD	_	7	conj	_	_
11	activated	activated	JJ	JJ	_	10	dobj	_	_
12	levels	level	NNS	NNS	_	7	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	expression	expression	NN	NN	_	12	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
18	LTR	ltr	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Second	second	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	17	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	lack	lack	VBP	VBP	_	4	acl:relcl	_	_
8	CD45	cd45	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	signal	signal	VB	VB	_	7	conj	_	_
13	via	via	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	TCR	tcr	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	supported	support	VBD	VBD	_	0	root	_	_
18	higher	higher	JJR	JJR	_	19	amod	_	_
19	levels	level	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	viral	viral	JJ	JJ	_	22	amod	_	_
22	replication	replication	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	6	nsubj	_	_
2	was	be	VBD	VBD	_	6	cop	_	_
3	due	due	JJ	JJ	_	6	case	_	_
4	to	to	TO	TO	_	3	mwe	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	11	case	_	_
8	active	active	JJ	JJ	_	11	amod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	complexes	complex	NNS	NNS	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	nucleus	nucleus	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	CD45-	cd45-	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Additionally	additionally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	infected	infected	JJ	JJ	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	displayed	display	VBD	VBD	_	0	root	_	_
7	lower	lower	JJR	JJR	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CD45	cd45	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
13	surfaces	surface	NNS	NNS	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	CD45	cd45	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	physiology	physiology	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	replication	replication	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HIV-1	hiv-1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	phosphatidylinositol	phosphatidylinositol	NN	NN	_	4	compound	_	_
4	turnover	turnover	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	EGR-1	egr-1	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	conj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	crosslinking	crosslink	VBG	VBG	_	1	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	surface	surface	NN	NN	_	10	nmod	_	_
13	IgM	igm	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IgD	igd	NN	NN	_	13	conj	_	_
16	in	in	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	B	b	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	B104	b104	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	a	a	DT	DT	_	11	det	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	B	b	NN	NN	_	11	compound	_	_
9	lymphoma	lymphoma	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	15	nsubj	_	_
12	,	,	,	,	_	11	punct	_	_
13	B104	b104	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	expressed	express	VBD	VBD	_	4	ccomp	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	IgM	igm	NN	NN	_	15	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	sIgM	sigm	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	surface	surface	NN	NN	_	23	compound	_	_
23	IgD	igd	NN	NN	_	17	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	sIgD	sigd	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	15	punct	_	_
28	and	and	CC	CC	_	15	cc	_	_
29	that	that	IN	IN	_	47	mark	_	_
30	crosslinking	crosslink	VBG	VBG	_	47	nsubj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	sIgM	sigm	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	sIgD	sigd	NN	NN	_	32	conj	_	_
35	by	by	IN	IN	_	37	case	_	_
36	anti-IgM	anti-igm	JJ	JJ	_	37	amod	_	_
37	antibody	antibody	NN	NN	_	30	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	Ab	ab	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	anti-IgD	anti-igd	JJ	JJ	_	43	amod	_	_
43	Ab	ab	NN	NN	_	37	conj	_	_
44	,	,	,	,	_	47	punct	_	_
45	respectively	respectively	RB	RB	_	47	advmod	_	_
46	,	,	,	,	_	47	punct	_	_
47	induced	induce	VBD	VBD	_	15	conj	_	_
48	Ca2+	ca2+	NN	NN	_	49	compound	_	_
49	influx	influx	NN	NN	_	47	dobj	_	_
50	to	to	TO	TO	_	54	case	_	_
51	almost	almost	RB	RB	_	53	advmod	_	_
52	the	the	DT	DT	_	53	det	_	_
53	same	same	JJ	JJ	_	54	amod	_	_
54	degree	degree	NN	NN	_	47	nmod	_	_
55	,	,	,	,	_	47	punct	_	_
56	whereas	whereas	IN	IN	_	47	dep	_	_
57	only	only	RB	RB	_	58	advmod	_	_
58	sIgM-crosslinking	sigm-crosslinking	NN	NN	_	59	nsubj	_	_
59	caused	cause	VBD	VBD	_	47	parataxis	_	_
60	B104	b104	NN	NN	_	62	compound	_	_
61	cell	cell	NN	NN	_	62	compound	_	_
62	death	death	NN	NN	_	59	dobj	_	_
63	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	accumulation	accumulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cyclic	cyclic	JJ	JJ	_	9	amod	_	_
9	AMP	amp	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	cAMP	camp	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	6	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	hydrolysis	hydrolysis	NN	NN	_	6	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	inositol	inositol	NN	NN	_	18	compound	_	_
18	phosphates	phosphate	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	protein	protein	NN	NN	_	22	compound	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	C	c	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PKC	pkc	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	activity	activity	NN	NN	_	6	conj	_	_
27	and	and	CC	CC	_	6	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	induction	induction	NN	NN	_	6	conj	_	_
30	of	of	IN	IN	_	35	case	_	_
31	Egr-1	egr-1	NN	NN	_	35	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	c-fos	c-fos	NN	NN	_	31	conj	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	29	nmod	_	_
36	by	by	IN	IN	_	37	case	_	_
37	sIgM-	sigm-	NN	NN	_	6	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	sIgD-crosslinking	sigd-crosslinking	NN	NN	_	37	conj	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	examine	examine	VB	VB	_	4	advcl	_	_
42	differences	difference	NNS	NNS	_	41	dobj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	signals	signal	NNS	NNS	_	42	nmod	_	_
46	mediated	mediate	VBN	VBN	_	45	acl	_	_
47	through	through	IN	IN	_	48	case	_	_
48	sIgM	sigm	NN	NN	_	46	nmod	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	sIgD	sigd	NN	NN	_	48	conj	_	_
51	in	in	IN	IN	_	53	case	_	_
52	B104	b104	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	46	nmod	_	_
54	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	sIgM-	sigm-	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	sIgD-crosslinking	sigd-crosslinking	NN	NN	_	2	conj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	antibodies	antibody	NNS	NNS	_	2	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	elevation	elevation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	cAMP	camp	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	phosphatidylinositol	phosphatidylinositol	NN	NN	_	14	compound	_	_
14	turnover	turnover	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	PKC	pkc	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	8	conj	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	expression	expression	NN	NN	_	8	conj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	Egr-1	egr-1	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	c-fos	c-fos	NN	NN	_	21	conj	_	_
24	mRNA	mrna	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	7	punct	_	_
26	although	although	IN	IN	_	30	mark	_	_
27	sIgM-crosslinking	sigm-crosslinking	NN	NN	_	30	nsubj	_	_
28	was	be	VBD	VBD	_	30	cop	_	_
29	more	more	RBR	RBR	_	30	advmod	_	_
30	effective	effective	JJ	JJ	_	7	advcl	_	_
31	than	than	IN	IN	_	32	case	_	_
32	sIgD-crosslinking	sigd-crosslinking	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	30	punct	_	_
34	presumably	presumably	RB	RB	_	39	advmod	_	_
35	due	due	JJ	JJ	_	39	case	_	_
36	to	to	TO	TO	_	35	mwe	_	_
37	the	the	DT	DT	_	39	det	_	_
38	higher	higher	JJR	JJR	_	39	amod	_	_
39	expression	expression	NN	NN	_	30	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	sIgM	sigm	NN	NN	_	39	nmod	_	_
42	than	than	IN	IN	_	44	case	_	_
43	of	of	IN	IN	_	44	case	_	_
44	sIgD	sigd	NN	NN	_	39	acl	_	_
45	.	.	.	.	_	7	punct	_	_

1	Egr-1	egr-1	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	10	nsubjpass	_	_
4	induced	induce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	sIgM-	sigm-	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	sIgD-crosslinking	sigd-crosslinking	NN	NN	_	6	conj	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	H7	h7	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	erbstatin	erbstatin	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	genistein	genistein	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	but	but	CC	CC	_	12	cc	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	by	by	IN	IN	_	21	case	_	_
21	HA1004	ha1004	NN	NN	_	12	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	Erbstatin	erbstatin	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	genistein	genistein	NN	NN	_	1	conj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	9	det	_	_
6	sIg-crosslinking-induced	sig-crosslinking-induced	JJ	JJ	_	9	amod	_	_
7	Egr-1	egr-1	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	dose-dependent	dose-dependent	JJ	JJ	_	13	amod	_	_
13	manner	manner	NN	NN	_	4	nmod	_	_
14	parallel	parallel	JJ	JJ	_	4	xcomp	_	_
15	to	to	TO	TO	_	16	case	_	_
16	that	that	WDT	WDT	_	14	nmod	_	_
17	observed	observe	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	inhibition	inhibition	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	sIg-crosslinking-induced	sig-crosslinking-induced	JJ	JJ	_	25	amod	_	_
23	protein	protein	NN	NN	_	25	compound	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	phosphorylation	phosphorylation	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Phorbol	phorbol	NN	NN	_	3	compound	_	_
2	myristate	myristate	NN	NN	_	3	compound	_	_
3	acetate	acetate	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	Egr-1	egr-1	NN	NN	_	7	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	forskolin	forskolin	NN	NN	_	14	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	dibutyryl	dibutyryl	NN	NN	_	13	compound	_	_
12	cyclic	cyclic	JJ	JJ	_	13	amod	_	_
13	AMP	amp	NN	NN	_	9	conj	_	_
14	did	do	VBD	VBD	_	4	conj	_	_
15	not	not	RB	RB	_	14	neg	_	_
16	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Egr-1	egr-1	NN	NN	_	9	compound	_	_
7	mRNA	mrna	NN	NN	_	9	compound	_	_
8	activating	activating	NN	NN	_	9	compound	_	_
9	signals	signal	NNS	NNS	_	17	nsubj	_	_
10	through	through	IN	IN	_	11	case	_	_
11	sIgM	sigm	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sIgD	sigd	NN	NN	_	11	conj	_	_
14	are	be	VBP	VBP	_	17	cop	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	kinase-	kinase-	NN	NN	_	3	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	PKC-dependent	pkc-dependent	JJ	JJ	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	but	but	CC	CC	_	17	cc	_	_
22	protein	protein	NN	NN	_	24	nmod:npmod	_	_
23	kinase	kinase	NN	NN	_	24	nmod:npmod	_	_
24	A-independent	a-independent	JJ	JJ	_	17	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CsA	csa	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	FK506	fk506	NN	NN	_	2	conj	_	_
8	rescued	rescue	VBD	VBD	_	0	root	_	_
9	B104	b104	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	8	dobj	_	_
11	from	from	IN	IN	_	12	case	_	_
12	death	death	NN	NN	_	8	nmod	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	anti-IgM	anti-igm	JJ	JJ	_	16	amod	_	_
16	Ab	ab	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	affect	affect	VB	VB	_	8	conj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	Egr-1	egr-1	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	c-fos	c-fos	NN	NN	_	25	conj	_	_
28	mRNA	mrna	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	8	punct	_	_
30	showing	show	VBG	VBG	_	8	advcl	_	_
31	that	that	IN	IN	_	35	mark	_	_
32	CsA	csa	NN	NN	_	35	nsubj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	FK506	fk506	NN	NN	_	32	conj	_	_
35	affect	affect	VBP	VBP	_	30	ccomp	_	_
36	signal	signal	NN	NN	_	37	compound	_	_
37	transducers	transducer	NNS	NNS	_	35	dobj	_	_
38	differently	differently	RB	RB	_	35	advmod	_	_
39	from	from	IN	IN	_	35	dep	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	downstream	downstream	RB	RB	_	39	conj	_	_
42	to	to	TO	TO	_	41	dep	_	_
43	these	these	DT	DT	_	44	det	_	_
44	molecules	molecule	NNS	NNS	_	39	dep	_	_
45	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	14	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	signals	signal	NNS	NNS	_	2	nmod	_	_
5	transduced	transduce	VBN	VBN	_	4	acl	_	_
6	through	through	IN	IN	_	7	case	_	_
7	sIgM	sigm	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	sIgD	sigd	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B104	b104	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	discussed	discuss	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	9	det	_	_
4	natural	natural	JJ	JJ	_	9	amod	_	_
5	bacterial	bacterial	JJ	JJ	_	9	amod	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	wall	wall	NN	NN	_	9	compound	_	_
8	breakdown	breakdown	NN	NN	_	9	compound	_	_
9	product	product	NN	NN	_	1	appos	_	_
10	,	,	,	,	_	1	punct	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	interleukin-1	interleukin-1	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	interleukin-6	interleukin-6	NN	NN	_	13	conj	_	_
16	expression	expression	NN	NN	_	11	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	2	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
13	published	publish	VBN	VBN	_	14	amod	_	_
14	erratum	erratum	NN	NN	_	15	nsubj	_	_
15	appears	appear	VBZ	VBZ	_	2	dep	_	_
16	in	in	IN	IN	_	19	case	_	_
17	J	J	NNP	NNP	_	19	compound	_	_
18	Biol	Biol	NNP	NNP	_	19	compound	_	_
19	Chem	Chem	NNP	NNP	_	15	nmod	_	_
20	1994	1994	CD	CD	_	21	nummod	_	_
21	Jun	Jun	NNP	NNP	_	19	dep	_	_
22	17	17	CD	CD	_	21	nummod	_	_
23	;	;	:	:	_	19	punct	_	_
24	269	269	CD	CD	_	26	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	24	24	CD	CD	_	19	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	:	:	:	:	_	19	punct	_	_
29	16983	16983	CD	CD	_	19	dep	_	_
30	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	believed	believe	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	induction	induction	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	13	case	_	_
10	bacterial	bacterial	JJ	JJ	_	13	amod	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	wall	wall	NN	NN	_	13	compound	_	_
13	components	component	NNS	NNS	_	5	nmod	_	_
14	plays	play	VBZ	VBZ	_	3	ccomp	_	_
15	a	a	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	development	development	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	course	course	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	sepsis	sepsis	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	most	most	JJS	JJS	_	4	amod	_	_
4	attention	attention	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	focused	focus	VBN	VBN	_	0	root	_	_
8	on	on	IN	IN	_	9	case	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LPS	lps	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D-isoglutamyl-m-diaminopimelyl-D-alanine	n-acetylglucosaminyl-1,6-anhydro-n-acetylmuramyl-l-alanyl-d-isoglutamyl-m-diaminopimelyl-d-alanine	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	a	a	DT	DT	_	15	det	_	_
12	naturally	naturally	RB	RB	_	13	advmod	_	_
13	occurring	occur	VBG	VBG	_	15	amod	_	_
14	breakdown	breakdown	NN	NN	_	15	compound	_	_
15	product	product	NN	NN	_	6	appos	_	_
16	of	of	IN	IN	_	17	case	_	_
17	peptidoglycan	peptidoglycan	NN	NN	_	15	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	produced	produce	VBN	VBN	_	15	acl:relcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	soluble	soluble	JJ	JJ	_	24	amod	_	_
23	lytic	lytic	JJ	JJ	_	24	amod	_	_
24	transglycosylase	transglycosylase	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	Escherichia	escherichia	FW	FW	_	27	compound	_	_
27	coli	coli	FW	FW	_	24	nmod	_	_
28	,	,	,	,	_	6	punct	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	induce	induce	VB	VB	_	4	acl	_	_
31	cytokine	cytokine	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	30	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	strongly	strongly	RB	RB	_	6	advmod	_	_
6	induce	induce	VB	VB	_	3	xcomp	_	_
7	interleukin	interleukin	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	IL	il	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	-1	-1	CD	CD	_	12	nummod	_	_
12	beta	beta	NN	NN	_	16	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL-6	il-6	NN	NN	_	12	conj	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	6	dobj	_	_
17	after	after	IN	IN	_	19	case	_	_
18	2	2	CD	CD	_	19	nummod	_	_
19	h	h	NN	NN	_	6	nmod	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	IL-1	il-1	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	26	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-6	il-6	NN	NN	_	22	conj	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	secretion	secretion	NN	NN	_	6	conj	_	_
27	after	after	IN	IN	_	29	case	_	_
28	48	48	CD	CD	_	29	nummod	_	_
29	h	h	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	activation	activation	NN	NN	_	6	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	accumulation	accumulation	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	13	cop	_	_
7	at	at	IN	IN	_	9	advmod	_	_
8	least	least	JJS	JJS	_	7	mwe	_	_
9	partly	partly	RB	RB	_	13	advmod	_	_
10	due	due	JJ	JJ	_	13	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	an	a	DT	DT	_	13	det	_	_
13	increase	increase	NN	NN	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	rates	rate	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	respective	respective	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	accompanied	accompany	VBN	VBN	_	13	conj	_	_
25	by	by	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	strong	strong	JJ	JJ	_	28	amod	_	_
28	induction	induction	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	38	case	_	_
30	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
31	factor-kappa	factor-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	38	compound	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	activator	activator	NN	NN	_	37	compound	_	_
35	protein-1	protein-1	NN	NN	_	37	compound	_	_
36	transcription	transcription	NN	NN	_	37	compound	_	_
37	factor	factor	NN	NN	_	32	conj	_	_
38	expression	expression	NN	NN	_	28	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	Experiments	experiment	NNS	NNS	_	17	nsubj	_	_
2	using	use	VBG	VBG	_	1	acl	_	_
3	inhibitors	inhibitor	NNS	NNS	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	C	c	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	A	a	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	tyrosine	tyrosine	NN	NN	_	15	nmod:npmod	_	_
15	kinase-dependent	kinase-dependent	JJ	JJ	_	16	amod	_	_
16	pathways	pathway	NNS	NNS	_	7	conj	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	26	mark	_	_
19	G(Anh)MTetra-induced	g(anh)mtetra-induced	JJ	JJ	_	25	amod	_	_
20	IL-1	il-1	NN	NN	_	21	compound	_	_
21	beta	beta	NN	NN	_	25	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-6	il-6	NN	NN	_	21	conj	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	26	nsubj	_	_
26	involves	involve	VBZ	VBZ	_	17	ccomp	_	_
27	activation	activation	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	an	a	DT	DT	_	31	det	_	_
30	H7-inhibitable	h7-inhibitable	JJ	JJ	_	31	amod	_	_
31	pathway	pathway	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	17	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	11	advcl	_	_
3	the	the	DT	DT	_	7	det	_	_
4	protein	protein	NN	NN	_	7	compound	_	_
5	synthesis	synthesis	NN	NN	_	7	compound	_	_
6	inhibitor	inhibitor	NN	NN	_	7	compound	_	_
7	cycloheximide	cycloheximide	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	11	punct	_	_
9	it	it	PRP	PRP	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	0	root	_	_
12	that	that	IN	IN	_	17	mark	_	_
13	G(Anh)MTetra-induced	g(anh)mtetra-induced	JJ	JJ	_	16	amod	_	_
14	IL-6	il-6	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	17	nsubj	_	_
17	depends	depend	VBZ	VBZ	_	11	ccomp	_	_
18	on	on	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	synthesis	synthesis	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	new	new	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	whereas	whereas	IN	IN	_	17	dep	_	_
26	G(Anh)MTetra-induced	g(anh)mtetra-induced	JJ	JJ	_	30	amod	_	_
27	IL-1	il-1	NN	NN	_	30	compound	_	_
28	beta	beta	NN	NN	_	30	compound	_	_
29	mRNA	mrna	NN	NN	_	30	compound	_	_
30	accumulation	accumulation	NN	NN	_	31	nsubj	_	_
31	does	do	VBZ	VBZ	_	17	parataxis	_	_
32	not	not	RB	RB	_	31	neg	_	_
33	.	.	.	.	_	11	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	responses	response	NNS	NNS	_	6	nsubjpass	_	_
3	to	to	TO	TO	_	4	case	_	_
4	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	compared	compare	VBN	VBN	_	19	advcl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	those	those	DT	DT	_	6	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	LPS	lps	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	muramyldipeptide	muramyldipeptide	NN	NN	_	10	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	MDP	mdp	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	19	punct	_	_
17	it	it	PRP	PRP	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	0	root	_	_
20	that	that	IN	IN	_	28	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	optimal	optimal	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	28	nsubj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	26	compound	_	_
26	induction	induction	NN	NN	_	23	nmod	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	similar	similar	JJ	JJ	_	19	ccomp	_	_
29	to	to	TO	TO	_	30	case	_	_
30	that	that	DT	DT	_	28	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	LPS	lps	NN	NN	_	30	nmod	_	_
33	but	but	CC	CC	_	28	cc	_	_
34	significantly	significantly	RB	RB	_	35	advmod	_	_
35	higher	higher	JJR	JJR	_	28	conj	_	_
36	than	than	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	response	response	NN	NN	_	35	nmod	_	_
39	to	to	TO	TO	_	40	case	_	_
40	MDP	mdp	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	19	punct	_	_

1	Furthermore	furthermore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	maximal	maximal	JJ	JJ	_	10	amod	_	_
4	G(Anh)MTetra-induced	g(anh)mtetra-induced	JJ	JJ	_	10	amod	_	_
5	IL-1	il-1	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-6	il-6	NN	NN	_	6	conj	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	13	nsubjpass	_	_
11	could	could	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	enhanced	enhance	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	co-stimulation	co-stimulation	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	LPS	lps	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	MDP	mdp	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	suggesting	suggest	VBG	VBG	_	13	xcomp	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	receptors	receptor	NNS	NNS	_	29	nsubjpass	_	_
25	and/or	and/or	CC	CC	_	24	cc	_	_
26	transduction	transduction	NN	NN	_	27	compound	_	_
27	pathways	pathway	NNS	NNS	_	24	conj	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	involved	involve	VBN	VBN	_	21	ccomp	_	_
30	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	IL-1	il-1	NN	NN	_	8	compound	_	_
8	beta	beta	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-6	il-6	NN	NN	_	8	conj	_	_
11	expression	expression	NN	NN	_	6	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	possible	possible	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	15	dobj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	G(Anh)MTetra	g(anh)mtetra	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	release	release	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	cytokines	cytokine	NNS	NNS	_	23	nmod	_	_
26	during	during	IN	IN	_	27	case	_	_
27	sepsis	sepsis	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	interferon	interferon	NN	NN	_	6	compound	_	_
3	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	2	2	CD	CD	_	6	nummod	_	_
6	gene	gene	NN	NN	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	Intron-exon	intron-exon	JJ	JJ	_	2	amod	_	_
2	organization	organization	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	analysis	analysis	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	5'-flanking	5'-flanking	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Interferon	interferon	NN	NN	_	3	compound	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	12	nsubj	_	_
4	2	2	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IRF-2	irf-2	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	0	root	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	terminates	terminate	VBZ	VBZ	_	12	acl:relcl	_	_
15	interferon	interferon	NN	NN	_	17	compound	_	_
16	beta	beta	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	initiated	initiate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	interferon	interferon	NN	NN	_	22	compound	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	isolated	isolate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	genomic	genomic	JJ	JJ	_	9	amod	_	_
9	DNA	dna	NN	NN	_	6	dobj	_	_
10	for	for	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	IRF-2	irf-2	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	determined	determine	VBD	VBD	_	6	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	intron-exon	intron-exon	JJ	JJ	_	18	amod	_	_
18	structure	structure	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	IRF-2	irf-2	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	6	punct	_	_
25	mapped	map	VBD	VBD	_	6	conj	_	_
26	the	the	DT	DT	_	30	det	_	_
27	major	major	JJ	JJ	_	30	amod	_	_
28	transcription	transcription	NN	NN	_	30	compound	_	_
29	initiation	initiation	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	25	dobj	_	_
31	,	,	,	,	_	6	punct	_	_
32	identified	identify	VBD	VBD	_	6	conj	_	_
33	a	a	DT	DT	_	34	det	_	_
34	number	number	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	potential	potential	JJ	JJ	_	38	amod	_	_
37	regulatory	regulatory	JJ	JJ	_	38	amod	_	_
38	elements	element	NNS	NNS	_	34	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	5'-flanking	5'-flanking	JJ	JJ	_	42	amod	_	_
42	region	region	NN	NN	_	38	nmod	_	_
43	,	,	,	,	_	6	punct	_	_
44	and	and	CC	CC	_	6	cc	_	_
45	localized	localize	VBD	VBD	_	6	conj	_	_
46	the	the	DT	DT	_	48	det	_	_
47	IRF-2	irf-2	NN	NN	_	48	compound	_	_
48	gene	gene	NN	NN	_	45	dobj	_	_
49	on	on	IN	IN	_	51	case	_	_
50	human	human	JJ	JJ	_	51	amod	_	_
51	chromosome	chromosome	NN	NN	_	48	nmod	_	_
52	4	4	CD	CD	_	51	nummod	_	_
53	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IRF-2	irf-2	NN	NN	_	4	compound	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	CpG	cpg	NN	NN	_	8	compound	_	_
8	island	island	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	with	with	IN	IN	_	13	case	_	_
11	several	several	JJ	JJ	_	13	amod	_	_
12	GC	gc	NN	NN	_	13	compound	_	_
13	boxes	box	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	19	det	_	_
16	putative	putative	JJ	JJ	_	19	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	nmod:npmod	_	_
18	B-binding	b-binding	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	a	a	DT	DT	_	24	det	_	_
23	CAAT	caat	NN	NN	_	24	compound	_	_
24	box	box	NN	NN	_	13	conj	_	_
25	,	,	,	,	_	13	punct	_	_
26	but	but	CC	CC	_	13	cc	_	_
27	no	no	DT	DT	_	29	neg	_	_
28	TATA	tata	NN	NN	_	29	compound	_	_
29	box	box	NN	NN	_	13	conj	_	_
30	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	linked	link	VBN	VBN	_	14	advcl	_	_
7	with	with	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	heterologous	heterologous	JJ	JJ	_	11	amod	_	_
10	reporter	reporter	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	found	find	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	inducible	inducible	JJ	JJ	_	14	ccomp	_	_
21	by	by	IN	IN	_	23	case	_	_
22	both	both	CC	CC	_	23	cc:preconj	_	_
23	interferons	interferon	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	interferon-alpha	interferon-alpha	NN	NN	_	23	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	-gamma	-gamma	NN	NN	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	interferon	interferon	NN	NN	_	32	compound	_	_
31	regulatory	regulatory	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	23	conj	_	_
33	1	1	CD	CD	_	32	nummod	_	_
34	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	8	nsubjpass	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	2	acl:relcl	_	_
5	these	these	DT	DT	_	6	det	_	_
6	inductions	induction	NNS	NNS	_	4	dobj	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	as	as	IN	IN	_	11	mark	_	_
10	being	be	VBG	VBG	_	11	auxpass	_	_
11	confined	confine	VBN	VBN	_	8	advcl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	40	40	CD	CD	_	14	nummod	_	_
14	nucleotides	nucleotide	NNS	NNS	_	11	nmod	_	_
15	5'	5'	JJ	JJ	_	14	nmod	_	_
16	to	to	TO	TO	_	15	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	major	major	JJ	JJ	_	21	amod	_	_
19	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
20	initiation	initiation	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	15	dep	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	testing	test	VBG	VBG	_	8	advcl	_	_
24	a	a	DT	DT	_	25	det	_	_
25	series	series	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	clones	clone	NNS	NNS	_	25	nmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	truncated	truncate	VBN	VBN	_	30	amod	_	_
30	promoter	promoter	NN	NN	_	23	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	IRF-2	irf-2	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	elements	element	NNS	NNS	_	3	dobj	_	_
5	which	which	WDT	WDT	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	shared	share	VBN	VBN	_	4	acl:relcl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	enhancers	enhancer	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	other	other	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	including	include	VBG	VBG	_	18	case	_	_
16	interferon	interferon	NN	NN	_	18	compound	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	11	nmod	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	,	,	,	,	_	18	punct	_	_
21	interferon	interferon	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	18	conj	_	_
23	,	,	,	,	_	18	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	interferon-inducible	interferon-inducible	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	18	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	interferon	interferon	NN	NN	_	7	compound	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	11	nsubj	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	11	cc:preconj	_	_
11	triggers	trigger	VBZ	VBZ	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	interferon	interferon	NN	NN	_	19	compound	_	_
17	signal	signal	NN	NN	_	19	compound	_	_
18	transduction	transduction	NN	NN	_	19	compound	_	_
19	pathway	pathway	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	but	but	CC	CC	_	11	cc	_	_
22	also	also	RB	RB	_	24	advmod	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	play	play	VB	VB	_	11	conj	_	_
25	a	a	DT	DT	_	26	det	_	_
26	role	role	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	28	mark	_	_
28	limiting	limit	VBG	VBG	_	24	advcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	duration	duration	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	response	response	NN	NN	_	30	nmod	_	_
34	by	by	IN	IN	_	35	mark	_	_
35	activating	activate	VBG	VBG	_	28	advcl	_	_
36	the	the	DT	DT	_	37	det	_	_
37	transcription	transcription	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	39	case	_	_
39	IRF-2	irf-2	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	rel	rel	NN	NN	_	4	nsubj	_	_
2	Is	be	VBZ	VBZ	_	4	aux	_	_
3	rapidly	rapidly	RB	RB	_	4	advmod	_	_
4	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	0	root	_	_
5	following	follow	VBG	VBG	_	9	case	_	_
6	granulocyte-colony	granulocyte-colony	JJ	JJ	_	9	amod	_	_
7	stimulating	stimulating	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	treatment	treatment	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	neutrophils	neutrophil	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	neutrophils	neutrophil	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	granulocyte-colony	granulocyte-colony	JJ	JJ	_	7	amod	_	_
6	stimulating	stimulating	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	G-CSF	g-csf	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	results	result	VBZ	VBZ	_	0	root	_	_
12	in	in	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	enhanced	enhance	VBN	VBN	_	16	amod	_	_
15	respiratory	respiratory	JJ	JJ	_	16	amod	_	_
16	burst	burst	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	prolonged	prolonged	JJ	JJ	_	19	amod	_	_
19	survival	survival	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	increased	increase	VBN	VBN	_	25	amod	_	_
23	tumor	tumor	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	killing	killing	NN	NN	_	16	conj	_	_
26	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	G-CSF	g-csf	NN	NN	_	2	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	binding	bind	VBG	VBG	_	6	nmod	_	_
9	to	to	TO	TO	_	14	case	_	_
10	specific	specific	JJ	JJ	_	14	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	high	high	JJ	JJ	_	13	amod	_	_
13	affinity	affinity	NN	NN	_	10	dep	_	_
14	receptors	receptor	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	G-CSF	g-csf	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	3	nsubj	_	_
3	lack	lack	VBP	VBP	_	0	root	_	_
4	intrinsic	intrinsic	JJ	JJ	_	7	amod	_	_
5	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	3	punct	_	_
9	but	but	CC	CC	_	3	cc	_	_
10	activation	activation	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	receptor	receptor	NN	NN	_	10	nmod	_	_
14	results	result	VBZ	VBZ	_	3	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	rapid	rapid	JJ	JJ	_	18	amod	_	_
18	induction	induction	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Antiphosphotyrosine	antiphosphotyrosine	JJ	JJ	_	2	amod	_	_
2	immunoblots	immunoblot	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	whole	whole	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lysates	lysate	NNS	NNS	_	2	nmod	_	_
7	prepared	prepare	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	9	case	_	_
9	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	15	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	G-CSF	g-csf	NN	NN	_	15	nsubj	_	_
14	rapidly	rapidly	RB	RB	_	15	advmod	_	_
15	induces	induce	VBZ	VBZ	_	10	ccomp	_	_
16	prominent	prominent	JJ	JJ	_	18	amod	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	protein	protein	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	relative	relative	JJ	JJ	_	26	amod	_	_
25	molecular	molecular	JJ	JJ	_	26	amod	_	_
26	mass	mass	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	80	80	CD	CD	_	29	nummod	_	_
29	kDa	kda	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	monospecific	monospecific	JJ	JJ	_	3	amod	_	_
3	antibodies	antibody	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	11	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	80-kDa	80-kda	JJ	JJ	_	8	amod	_	_
7	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	11	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	p80c-rel	p80c-rel	NN	NN	_	11	xcomp	_	_
15	,	,	,	,	_	14	punct	_	_
16	a	a	DT	DT	_	17	det	_	_
17	proto-oncogene	proto-oncogene	NN	NN	_	14	appos	_	_
18	belonging	belong	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	family	family	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	regulators	regulator	NNS	NNS	_	21	nmod	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	include	include	VBP	VBP	_	24	acl:relcl	_	_
27	NF-kB	nf-kb	NN	NN	_	26	dobj	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p80c-rel	p80c-rel	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	unique	unique	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	G-CSF	g-csf	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	28	mark	_	_
13	that	that	IN	IN	_	28	mark	_	_
14	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	17	amod	_	_
15	colony	colony	NN	NN	_	17	compound	_	_
16	stimulating	stimulating	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	28	nsubj	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	stimulates	stimulate	VBZ	VBZ	_	17	acl:relcl	_	_
21	neutrophils	neutrophil	NNS	NNS	_	20	dobj	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	induces	induce	VBZ	VBZ	_	20	conj	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	phosphorylation	phosphorylation	NN	NN	_	23	dobj	_	_
26	does	do	VBZ	VBZ	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	result	result	VB	VB	_	9	advcl	_	_
29	in	in	IN	IN	_	31	case	_	_
30	tyrosine	tyrosine	NN	NN	_	31	compound	_	_
31	phosphorylation	phosphorylation	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	p80c-rel	p80c-rel	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	consequences	consequence	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	p80c-rel	p80c-rel	NN	NN	_	6	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
7	are	be	VBP	VBP	_	10	auxpass	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	yet	yet	RB	RB	_	10	advmod	_	_
10	known	know	VBN	VBN	_	0	root	_	_
11	;	;	:	:	_	10	punct	_	_
12	however	however	RB	RB	_	17	advmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	15	amod	_	_
15	p80c-rel	p80c-rel	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	capable	capable	JJ	JJ	_	10	parataxis	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	binding	bind	VBG	VBG	_	17	advcl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	DNA	dna	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	G-CSF	g-csf	NN	NN	_	25	compound	_	_
25	stimulation	stimulation	NN	NN	_	26	nsubj	_	_
26	results	result	VBZ	VBZ	_	17	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	an	a	DT	DT	_	29	det	_	_
29	increase	increase	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	amount	amount	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	p80c-rel	p80c-rel	NN	NN	_	32	nmod	_	_
35	which	which	WDT	WDT	_	36	nsubj	_	_
36	binds	bind	VBZ	VBZ	_	34	acl:relcl	_	_
37	to	to	TO	TO	_	38	case	_	_
38	DNA	dna	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	one	one	CD	CD	_	25	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	first	first	JJ	JJ	_	10	amod	_	_
9	biochemical	biochemical	JJ	JJ	_	10	amod	_	_
10	events	event	NNS	NNS	_	5	nmod	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	occurs	occur	VBZ	VBZ	_	5	acl:relcl	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
15	following	follow	VBG	VBG	_	17	case	_	_
16	G-CSF	g-csf	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	activation	activation	NN	NN	_	5	appos	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	5	punct	_	_
25	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
26	directly	directly	RB	RB	_	25	advmod	_	_
27	to	to	TO	TO	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	tyrosine	tyrosine	NN	NN	_	30	compound	_	_
30	phosphorylation	phosphorylation	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	p80c-rel	p80c-rel	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	9	nsubj	_	_
6	activated	activate	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	G-CSF	g-csf	NN	NN	_	6	nmod	_	_
9	appears	appear	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	directly	directly	RB	RB	_	12	advmod	_	_
12	transduce	transduce	VB	VB	_	9	xcomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	signal	signal	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	protein	protein	NN	NN	_	12	nmod	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	functions	function	VBZ	VBZ	_	17	acl:relcl	_	_
20	as	as	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	regulator	regulator	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Overproduction	overproduction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NFKB2	nfkb2	NN	NN	_	1	nmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	lyt-10	lyt-10	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	c-Rel	c-rel	NN	NN	_	3	conj	_	_
9	:	:	:	:	_	1	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	mechanism	mechanism	NN	NN	_	1	dep	_	_
12	for	for	IN	IN	_	15	case	_	_
13	HTLV-I	htlv-i	NN	NN	_	15	compound	_	_
14	Tax-mediated	tax-mediated	JJ	JJ	_	15	amod	_	_
15	trans-activation	trans-activation	NN	NN	_	11	nmod	_	_
16	via	via	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	signalling	signalling	NN	NN	_	21	compound	_	_
21	pathway	pathway	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	Molecular	molecular	JJ	JJ	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	biochemical	biochemical	JJ	JJ	_	1	conj	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	epidemiological	epidemiological	JJ	JJ	_	1	conj	_	_
6	evidence	evidence	NN	NN	_	1	dep	_	_
7	implicate	implicate	VBP	VBP	_	0	root	_	_
8	HTLV-I	htlv-i	NN	NN	_	7	dobj	_	_
9	as	as	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	etiologic	etiologic	JJ	JJ	_	12	amod	_	_
12	agent	agent	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	adult	adult	JJ	JJ	_	17	amod	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATL	atl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	19	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HTLV-I	htlv-i	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	a	a	DT	DT	_	10	det	_	_
8	positive	positive	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activator	activator	NN	NN	_	3	appos	_	_
11	of	of	IN	IN	_	14	case	_	_
12	HTLV-I	htlv-i	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	oncogene	oncogene	NN	NN	_	0	root	_	_
20	that	that	WDT	WDT	_	22	nsubj	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	increases	increase	VBZ	VBZ	_	19	acl:relcl	_	_
23	transcription	transcription	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	cellular	cellular	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	23	nmod	_	_
27	including	include	VBG	VBG	_	28	case	_	_
28	GM-CSF	gm-csf	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	IL-2R	il-2r	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	28	conj	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	IL-2	il-2	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	19	punct	_	_

1	One	one	CD	CD	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	cellular	cellular	JJ	JJ	_	5	amod	_	_
5	targets	target	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	trans-activating	trans-activating	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Tax	tax	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	the	the	DT	DT	_	16	det	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B/Rel	b/rel	NN	NN	_	16	compound	_	_
16	family	family	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	pleiotropic	pleiotropic	JJ	JJ	_	22	amod	_	_
22	regulators	regulator	NNS	NNS	_	19	appos	_	_
23	of	of	IN	IN	_	24	case	_	_
24	immunoregulatory	immunoregulatory	JJ	JJ	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	cytokine	cytokine	NN	NN	_	24	conj	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	viral	viral	JJ	JJ	_	24	conj	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	24	dep	_	_
31	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	NFKB2	nfkb2	NN	NN	_	15	nsubjpass	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	lyt-10	lyt-10	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	c-Rel	c-rel	NN	NN	_	8	conj	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	overexpressed	overexpress	VBN	VBN	_	6	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	HTLV-I	htlv-i	NN	NN	_	18	nmod:npmod	_	_
18	infected	infected	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Tax-expressing	tax-expressing	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	,	,	,	,	_	15	punct	_	_
24	together	together	RB	RB	_	15	advmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	account	account	VBP	VBP	_	15	dep	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	majority	majority	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	36	case	_	_
31	the	the	DT	DT	_	36	det	_	_
32	constitutive	constitutive	JJ	JJ	_	36	amod	_	_
33	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	activity	activity	NN	NN	_	29	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	these	these	DT	DT	_	39	det	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	before	before	IN	IN	_	44	nmod	_	_
41	and	and	CC	CC	_	44	cc	_	_
42	after	after	IN	IN	_	44	conj	_	_
43	PMA	pma	NN	NN	_	44	compound	_	_
44	stimulation	stimulation	NN	NN	_	36	nmod	_	_
45	.	.	.	.	_	6	punct	_	_

1	Most	most	RBS	RBS	_	2	advmod	_	_
2	importantly	importantly	RB	RB	_	5	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	Tax-dependent	tax-dependent	JJ	JJ	_	8	amod	_	_
8	correlation	correlation	NN	NN	_	5	dobj	_	_
9	between	between	IN	IN	_	10	case	_	_
10	expression	expression	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFKB2	nfkb2	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	p100	p100	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	processing	processing	NN	NN	_	10	conj	_	_
18	to	to	TO	TO	_	26	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	DNA	dna	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	NFKB2	nfkb2	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	p52	p52	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	form	form	NN	NN	_	17	nmod	_	_
27	,	,	,	,	_	10	punct	_	_
28	induction	induction	NN	NN	_	10	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	c-Rel	c-rel	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	10	punct	_	_
32	and	and	CC	CC	_	10	cc	_	_
33	trans-activation	trans-activation	NN	NN	_	10	conj	_	_
34	of	of	IN	IN	_	38	case	_	_
35	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
36	B-mediated	b-mediated	JJ	JJ	_	38	amod	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NFKB2	nfkb2	NN	NN	_	5	compound	_	_
5	precursor	precursor	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	physically	physically	RB	RB	_	8	advmod	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	c-Rel	c-rel	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Tax	tax	NN	NN	_	10	conj	_	_
14	in	in	NN	NN	_	17	dep	_	_
15	HTLV-I	htlv-i	NN	NN	_	17	compound	_	_
16	infected	infected	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	NFKB2	nfkb2	NN	NN	_	8	nsubj	_	_
5	synthesis	synthesis	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	processing	processing	NN	NN	_	4	conj	_	_
8	allows	allow	VBZ	VBZ	_	2	ccomp	_	_
9	continuous	continuous	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	otherwise	otherwise	RB	RB	_	16	advmod	_	_
15	cytoplasmic	cytoplasmic	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	,	,	,	,	_	8	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	conjunction	conjunction	NN	NN	_	27	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	overexpression	overexpression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	c-Rel	c-rel	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	27	punct	_	_
26	NFKB2	nfkb2	NN	NN	_	27	nsubj	_	_
27	alters	alter	VBZ	VBZ	_	8	conj	_	_
28	the	the	DT	DT	_	32	det	_	_
29	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
30	B	b	NN	NN	_	32	compound	_	_
31	signalling	signalling	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	27	dobj	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	contributes	contribute	VBZ	VBZ	_	27	conj	_	_
35	to	to	TO	TO	_	37	case	_	_
36	leukemic	leukemic	JJ	JJ	_	37	amod	_	_
37	transformation	transformation	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	37	nmod	_	_
41	by	by	IN	IN	_	42	case	_	_
42	HTLV-I	htlv-i	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Autoregulation	autoregulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	transactivator	transactivator	NN	NN	_	1	nmod	_	_
7	RelA	rela	NN	NN	_	6	dep	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	p65	p65	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	by	by	IN	IN	_	14	case	_	_
12	multiple	multiple	JJ	JJ	_	14	amod	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	ankyrin	ankyrin	NN	NN	_	17	compound	_	_
17	motifs	motif	NNS	NNS	_	15	dobj	_	_
18	.	.	.	.	_	1	punct	_	_

1	RelA	rela	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	p65	p65	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	functions	function	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	critical	critical	JJ	JJ	_	10	amod	_	_
9	transactivating	transactivate	VBG	VBG	_	10	amod	_	_
10	component	component	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	heterodimeric	heterodimeric	JJ	JJ	_	17	amod	_	_
14	p50-p65	p50-p65	NN	NN	_	17	compound	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	10	nmod	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	contains	contain	VBZ	VBZ	_	5	conj	_	_
20	a	a	DT	DT	_	23	det	_	_
21	high-affinity	high-affinity	JJ	JJ	_	23	amod	_	_
22	binding	bind	VBG	VBG	_	23	amod	_	_
23	site	site	NN	NN	_	19	dobj	_	_
24	for	for	IN	IN	_	27	case	_	_
25	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
26	cytoplasmic	cytoplasmic	JJ	JJ	_	27	amod	_	_
27	inhibitor	inhibitor	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	I	i	NN	NN	_	32	compound	_	_
30	kappa	kappa	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	27	appos	_	_
33	.	.	.	.	_	5	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	rapidly	rapidly	RB	RB	_	11	advmod	_	_
11	degraded	degrade	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	18	case	_	_
13	concert	concert	NN	NN	_	18	dep	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	induced	induce	VBN	VBN	_	18	amod	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	translocation	translocation	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	tumor	tumor	NN	NN	_	9	nmod:npmod	_	_
7	necrosis	necrosis	NN	NN	_	9	nmod:npmod	_	_
8	factor	factor	NN	NN	_	9	nmod:npmod	_	_
9	alpha-induced	alpha-induced	JJ	JJ	_	10	amod	_	_
10	degradation	degradation	NN	NN	_	21	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	I	i	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	preceded	precede	VBN	VBN	_	4	ccomp	_	_
22	by	by	IN	IN	_	25	case	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	rapid	rapid	JJ	JJ	_	25	amod	_	_
25	phosphorylation	phosphorylation	NN	NN	_	21	nmod	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vivo	vivo	FW	FW	_	25	advmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	10	nsubj	_	_
5	on	on	IN	IN	_	9	case	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	4	nmod	_	_
10	result	result	VBP	VBP	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	mobilization	mobilization	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	only	only	RB	RB	_	17	advmod	_	_
16	a	a	DT	DT	_	17	det	_	_
17	fraction	fraction	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	entire	entire	JJ	JJ	_	22	amod	_	_
21	cytoplasmic	cytoplasmic	JJ	JJ	_	22	amod	_	_
22	pool	pool	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	RelA	rela	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Subsequent	subsequent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	revealed	reveal	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	i	i	LS	LS	_	13	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	RelA	rela	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	stably	stably	RB	RB	_	13	advmod	_	_
13	associated	associate	VBN	VBN	_	4	ccomp	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	only	only	RB	RB	_	20	cc:preconj	_	_
16	with	with	IN	IN	_	20	case	_	_
17	I	i	NN	NN	_	20	compound	_	_
18	kappa	kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	13	nmod	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	also	also	RB	RB	_	27	advmod	_	_
23	with	with	IN	IN	_	27	case	_	_
24	other	other	JJ	JJ	_	27	amod	_	_
25	ankyrin	ankyrin	NN	NN	_	27	compound	_	_
26	motif-rich	motif-rich	JJ	JJ	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	20	conj	_	_
28	including	include	VBG	VBG	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	products	product	NNS	NNS	_	27	nmod	_	_
31	of	of	IN	IN	_	44	case	_	_
32	the	the	DT	DT	_	44	det	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B2	b2	NN	NN	_	44	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	p100	p100	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B1	b1	NN	NN	_	34	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	p105	p105	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	genes	gene	NNS	NNS	_	30	nmod	_	_
45	;	;	:	:	_	13	punct	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	ii	ii	LS	LS	_	62	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	in	in	IN	IN	_	55	case	_	_
50	contrast	contrast	NN	NN	_	55	dep	_	_
51	to	to	TO	TO	_	55	case	_	_
52	RelA-I	rela-i	NN	NN	_	55	compound	_	_
53	kappa	kappa	NN	NN	_	55	compound	_	_
54	B	b	NN	NN	_	55	compound	_	_
55	alpha	alpha	NN	NN	_	62	nmod	_	_
56	,	,	,	,	_	62	punct	_	_
57	RelA-p100	rela-p100	NN	NN	_	59	compound	_	_
58	cytoplasmic	cytoplasmic	JJ	JJ	_	59	amod	_	_
59	complexes	complex	NNS	NNS	_	62	nsubjpass	_	_
60	are	be	VBP	VBP	_	62	auxpass	_	_
61	not	not	RB	RB	_	62	neg	_	_
62	dissociated	dissociate	VBN	VBN	_	13	conj	_	_
63	following	follow	VBG	VBG	_	68	case	_	_
64	tumor	tumor	NN	NN	_	68	compound	_	_
65	necrosis	necrosis	NN	NN	_	68	compound	_	_
66	factor	factor	NN	NN	_	68	compound	_	_
67	alpha	alpha	NN	NN	_	68	compound	_	_
68	activation	activation	NN	NN	_	62	nmod	_	_
69	;	;	:	:	_	13	punct	_	_
70	(	(	-LRB-	-LRB-	_	71	punct	_	_
71	iii	iii	LS	LS	_	74	dep	_	_
72	)	)	-RRB-	-RRB-	_	71	punct	_	_
73	p100	p100	NN	NN	_	74	nsubj	_	_
74	functions	function	VBZ	VBZ	_	13	conj	_	_
75	as	as	IN	IN	_	78	case	_	_
76	a	a	DT	DT	_	78	det	_	_
77	potent	potent	JJ	JJ	_	78	amod	_	_
78	inhibitor	inhibitor	NN	NN	_	74	nmod	_	_
79	of	of	IN	IN	_	81	case	_	_
80	RelA-mediated	rela-mediated	JJ	JJ	_	81	amod	_	_
81	transcription	transcription	NN	NN	_	78	nmod	_	_
82	in	in	FW	FW	_	83	compound	_	_
83	vivo	vivo	FW	FW	_	81	advmod	_	_
84	;	;	:	:	_	13	punct	_	_
85	(	(	-LRB-	-LRB-	_	86	punct	_	_
86	iv	iv	LS	LS	_	94	dep	_	_
87	)	)	-RRB-	-RRB-	_	86	punct	_	_
88	the	the	DT	DT	_	89	det	_	_
89	interaction	interaction	NN	NN	_	94	nsubj	_	_
90	of	of	IN	IN	_	91	case	_	_
91	RelA	rela	NN	NN	_	89	nmod	_	_
92	and	and	CC	CC	_	91	cc	_	_
93	p100	p100	NN	NN	_	91	conj	_	_
94	involves	involve	VBZ	VBZ	_	13	conj	_	_
95	the	the	DT	DT	_	99	det	_	_
96	conserved	conserve	VBN	VBN	_	99	amod	_	_
97	Rel	rel	NN	NN	_	99	compound	_	_
98	homology	homology	NN	NN	_	99	compound	_	_
99	domain	domain	NN	NN	_	94	dobj	_	_
100	of	of	IN	IN	_	102	case	_	_
101	both	both	DT	DT	_	102	det	_	_
102	proteins	protein	NNS	NNS	_	99	nmod	_	_
103	but	but	CC	CC	_	104	cc	_	_
104	not	not	RB	RB	_	99	cc	_	_
105	the	the	DT	DT	_	108	det	_	_
106	nuclear	nuclear	JJ	JJ	_	108	amod	_	_
107	localization	localization	NN	NN	_	108	compound	_	_
108	signal	signal	NN	NN	_	99	conj	_	_
109	of	of	IN	IN	_	110	case	_	_
110	RelA	rela	NN	NN	_	108	nmod	_	_
111	,	,	,	,	_	108	punct	_	_
112	which	which	WDT	WDT	_	114	nsubjpass	_	_
113	is	be	VBZ	VBZ	_	114	auxpass	_	_
114	required	require	VBN	VBN	_	108	acl:relcl	_	_
115	for	for	IN	IN	_	120	case	_	_
116	I	i	NN	NN	_	120	compound	_	_
117	kappa	kappa	NN	NN	_	120	compound	_	_
118	B	b	NN	NN	_	120	compound	_	_
119	alpha	alpha	NN	NN	_	120	compound	_	_
120	binding	binding	NN	NN	_	114	nmod	_	_
121	;	;	:	:	_	13	punct	_	_
122	(	(	-LRB-	-LRB-	_	123	punct	_	_
123	v	v	LS	LS	_	130	dep	_	_
124	)	)	-RRB-	-RRB-	_	123	punct	_	_
125	p100	p100	NN	NN	_	126	compound	_	_
126	inhibition	inhibition	NN	NN	_	130	nsubj	_	_
127	of	of	IN	IN	_	129	case	_	_
128	RelA	rela	NN	NN	_	129	compound	_	_
129	function	function	NN	NN	_	126	nmod	_	_
130	requires	require	VBZ	VBZ	_	13	conj	_	_
131	the	the	DT	DT	_	135	det	_	_
132	C-terminal	c-terminal	JJ	JJ	_	135	amod	_	_
133	ankyrin	ankyrin	NN	NN	_	135	compound	_	_
134	motif	motif	NN	NN	_	135	compound	_	_
135	domain	domain	NN	NN	_	130	dobj	_	_
136	,	,	,	,	_	135	punct	_	_
137	which	which	WDT	WDT	_	138	nsubj	_	_
138	mediates	mediate	VBZ	VBZ	_	135	acl:relcl	_	_
139	cytoplasmic	cytoplasmic	JJ	JJ	_	140	amod	_	_
140	retention	retention	NN	NN	_	138	dobj	_	_
141	of	of	IN	IN	_	142	case	_	_
142	RelA	rela	NN	NN	_	140	nmod	_	_
143	;	;	:	:	_	13	punct	_	_
144	and	and	CC	CC	_	13	cc	_	_
145	(	(	-LRB-	-LRB-	_	146	punct	_	_
146	vi	vi	LS	LS	_	158	dep	_	_
147	)	)	-RRB-	-RRB-	_	146	punct	_	_
148	as	as	IN	IN	_	149	mark	_	_
149	observed	observe	VBN	VBN	_	158	advcl	_	_
150	with	with	IN	IN	_	154	case	_	_
151	I	I	PRP	PRP	_	154	dep	_	_
152	kappa	kappa	NN	NN	_	154	compound	_	_
153	B	b	NN	NN	_	154	compound	_	_
154	alpha	alpha	NN	NN	_	149	nmod	_	_
155	,	,	,	,	_	158	punct	_	_
156	nuclear	nuclear	JJ	JJ	_	157	amod	_	_
157	RelA	rela	NN	NN	_	158	nsubj	_	_
158	stimulates	stimulate	VBZ	VBZ	_	13	conj	_	_
159	p100	p100	NN	NN	_	163	compound	_	_
160	mRNA	mrna	NN	NN	_	163	compound	_	_
161	and	and	CC	CC	_	160	cc	_	_
162	protein	protein	NN	NN	_	160	conj	_	_
163	expression	expression	NN	NN	_	158	dobj	_	_
164	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	reveal	reveal	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	a	a	DT	DT	_	13	det	_	_
9	second	second	JJ	JJ	_	13	amod	_	_
10	inducible	inducible	JJ	JJ	_	13	amod	_	_
11	autoregulated	autoregulated	JJ	JJ	_	13	amod	_	_
12	inhibitory	inhibitory	JJ	JJ	_	13	amod	_	_
13	pathway	pathway	NN	NN	_	6	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	helps	help	VBZ	VBZ	_	13	acl:relcl	_	_
16	ensure	ensure	VB	VB	_	15	ccomp	_	_
17	the	the	DT	DT	_	21	det	_	_
18	rapid	rapid	JJ	JJ	_	21	amod	_	_
19	but	but	CC	CC	_	18	cc	_	_
20	transient	transient	JJ	JJ	_	18	conj	_	_
21	action	action	NN	NN	_	16	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	2	nsubj	_	_
2	acts	act	VBZ	VBZ	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	synergy	synergy	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PMA	pma	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	inactivate	inactivate	VB	VB	_	2	xcomp	_	_
9	I	i	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B/MAD3	b/mad3	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	an	a	DT	DT	_	14	det	_	_
14	inhibitor	inhibitor	NN	NN	_	11	appos	_	_
15	of	of	IN	IN	_	17	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-2	il-2	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	promoter	promoter	NN	NN	_	7	nsubj	_	_
7	consists	consist	VBZ	VBZ	_	0	root	_	_
8	of	of	IN	IN	_	18	case	_	_
9	several	several	JJ	JJ	_	18	amod	_	_
10	independent	independent	JJ	JJ	_	18	amod	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	17	nmod:npmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TcR	tcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	responsive	responsive	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	promoters	promoter	NNS	NNS	_	2	nmod	_	_
5	dependent	dependent	JJ	JJ	_	2	amod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	elements	element	NNS	NNS	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	inhibitable	inhibitable	JJ	JJ	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	immunosuppressants	immunosuppressant	NNS	NNS	_	10	nmod	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	13	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CsA	csa	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	tacrolimus	tacrolimus	NN	NN	_	15	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	FK-506	fk-506	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	10	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	13	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	phosphatase	phosphatase	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	1	punct	_	_
8	is	be	VBZ	VBZ	_	13	cop	_	_
9	the	the	DT	DT	_	13	det	_	_
10	FK-506-	fk-506-	NN	NN	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CsA-sensitive	csa-sensitive	JJ	JJ	_	10	conj	_	_
13	enzyme	enzyme	NN	NN	_	0	root	_	_
14	required	require	VBN	VBN	_	13	acl	_	_
15	for	for	IN	IN	_	18	case	_	_
16	TcR	tcr	NN	NN	_	17	nmod:npmod	_	_
17	mediated	mediated	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	a	a	DT	DT	_	7	det	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	form	form	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	calcineurin	calcineurin	NN	NN	_	7	nmod	_	_
10	partially	partially	RB	RB	_	11	advmod	_	_
11	substitutes	substitute	VBZ	VBZ	_	2	ccomp	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Ca2+	ca2+	NN	NN	_	15	compound	_	_
15	co-stimulus	co-stimulus	NN	NN	_	11	nmod	_	_
16	required	require	VBN	VBN	_	15	acl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	activate	activate	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	22	det	_	_
20	IL-2	il-2	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	elements	element	NNS	NNS	_	18	dobj	_	_
23	IL-2A	il-2a	NN	NN	_	22	dep	_	_
24	(	(	-LRB-	-LRB-	_	23	punct	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	binds	bind	VBZ	VBZ	_	23	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	factors	factor	NNS	NNS	_	26	dobj	_	_
29	OAP	oap	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Oct-1	oct-1	NN	NN	_	29	conj	_	_
32	)	)	-RRB-	-RRB-	_	23	punct	_	_
33	and	and	CC	CC	_	23	cc	_	_
34	IL-2E	il-2e	NN	NN	_	23	conj	_	_
35	(	(	-LRB-	-LRB-	_	34	punct	_	_
36	which	which	WDT	WDT	_	37	nsubj	_	_
37	binds	bind	VBZ	VBZ	_	34	acl:relcl	_	_
38	NF-AT	nf-at	NN	NN	_	37	dobj	_	_
39	)	)	-RRB-	-RRB-	_	34	punct	_	_
40	,	,	,	,	_	11	punct	_	_
41	and	and	CC	CC	_	11	cc	_	_
42	completely	completely	RB	RB	_	43	advmod	_	_
43	substitutes	substitute	VBZ	VBZ	_	11	conj	_	_
44	for	for	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	Ca2+	ca2+	NN	NN	_	47	compound	_	_
47	co-stimulus	co-stimulus	NN	NN	_	43	nmod	_	_
48	required	require	VBN	VBN	_	47	acl	_	_
49	to	to	TO	TO	_	50	mark	_	_
50	stimulate	stimulate	VB	VB	_	48	xcomp	_	_
51	an	a	DT	DT	_	54	det	_	_
52	NF-kappa	nf-kappa	NN	NN	_	53	nmod:npmod	_	_
53	B-dependent	b-dependent	JJ	JJ	_	54	amod	_	_
54	element	element	NN	NN	_	50	dobj	_	_
55	.	.	.	.	_	2	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	2	nsubj	_	_
2	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	2	dobj	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	enhancing	enhance	VBG	VBG	_	2	advcl	_	_
9	inactivation	inactivation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	I	i	NN	NN	_	13	compound	_	_
12	kappa	kappa	NN	NN	_	13	compound	_	_
13	B/MAD3	b/mad3	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	an	a	DT	DT	_	16	det	_	_
16	inhibitor	inhibitor	NN	NN	_	13	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	thereby	thereby	RB	RB	_	22	advmod	_	_
22	increasing	increase	VBG	VBG	_	8	dep	_	_
23	the	the	DT	DT	_	24	det	_	_
24	amount	amount	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	31	case	_	_
26	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
27	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
28	B	b	NN	NN	_	31	compound	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	demonstration	demonstration	NN	NN	_	3	dobj	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vivo	vivo	FW	FW	_	6	advmod	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	activation	activation	NN	NN	_	16	nsubj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	phosphatase	phosphatase	NN	NN	_	10	nmod	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	inactivate	inactivate	VB	VB	_	6	dep	_	_
17	I	i	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	3	punct	_	_
21	and	and	CC	CC	_	3	cc	_	_
22	suggest	suggest	VBP	VBP	_	3	conj	_	_
23	one	one	CD	CD	_	25	nummod	_	_
24	possible	possible	JJ	JJ	_	25	amod	_	_
25	explanation	explanation	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	28	case	_	_
27	mechanism-based	mechanism-based	JJ	JJ	_	28	amod	_	_
28	toxicities	toxicity	NNS	NNS	_	25	nmod	_	_
29	associated	associate	VBN	VBN	_	28	acl	_	_
30	with	with	IN	IN	_	31	case	_	_
31	FK-506	fk-506	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	CsA	csa	NN	NN	_	31	conj	_	_
34	by	by	IN	IN	_	35	mark	_	_
35	demonstrating	demonstrate	VBG	VBG	_	22	advcl	_	_
36	that	that	IN	IN	_	40	mark	_	_
37	these	these	DT	DT	_	38	det	_	_
38	drugs	drug	NNS	NNS	_	40	nsubj	_	_
39	can	can	MD	MD	_	40	aux	_	_
40	inhibit	inhibit	VB	VB	_	35	ccomp	_	_
41	the	the	DT	DT	_	43	det	_	_
42	calcineurin-dependent	calcineurin-dependent	JJ	JJ	_	43	amod	_	_
43	activation	activation	NN	NN	_	40	dobj	_	_
44	of	of	IN	IN	_	49	case	_	_
45	a	a	DT	DT	_	49	det	_	_
46	virtually	virtually	RB	RB	_	47	advmod	_	_
47	ubiquitous	ubiquitous	JJ	JJ	_	49	amod	_	_
48	transcription	transcription	NN	NN	_	49	compound	_	_
49	factor	factor	NN	NN	_	43	nmod	_	_
50	.	.	.	.	_	3	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	exposure	exposure	NN	NN	_	8	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TCDD	tcdd	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	increases	increase	VBZ	VBZ	_	0	root	_	_
9	infectivity	infectivity	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	erythrocytes	erythrocyte	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	malarial	malarial	JJ	JJ	_	16	amod	_	_
16	parasite	parasite	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	exposure	exposure	NN	NN	_	7	nsubj	_	_
3	to	to	TO	TO	_	6	case	_	_
4	10	10	CD	CD	_	5	compound	_	_
5	nM	nm	NN	NN	_	6	amod	_	_
6	2,3,7,8-TCDD	2,3,7,8-tcdd	NN	NN	_	2	nmod	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	75	75	CD	CD	_	11	nummod	_	_
10	%	%	NN	NN	_	11	compound	_	_
11	increase	increase	NN	NN	_	7	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	a	a	DT	DT	_	15	det	_	_
14	2-fold	2-fold	JJ	JJ	_	15	nummod	_	_
15	increase	increase	NN	NN	_	11	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	infectivity	infectivity	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	isolated	isolate	VBN	VBN	_	22	amod	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	erythrocytes	erythrocyte	NNS	NNS	_	18	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	P.	p.	FW	FW	_	25	compound	_	_
25	falciparum	falciparum	FW	FW	_	18	nmod	_	_
26	after	after	IN	IN	_	28	case	_	_
27	48	48	CD	CD	_	28	nummod	_	_
28	hours	hour	NNS	NNS	_	7	nmod	_	_
29	when	when	WRB	WRB	_	38	advmod	_	_
30	the	the	DT	DT	_	31	det	_	_
31	parasites	parasite	NNS	NNS	_	38	nsubj	_	_
32	were	be	VBD	VBD	_	38	cop	_	_
33	in	in	IN	IN	_	38	case	_	_
34	an	a	DT	DT	_	38	det	_	_
35	unsynchronized	unsynchronized	JJ	JJ	_	38	amod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	synchronized	synchronized	JJ	JJ	_	35	conj	_	_
38	state	state	NN	NN	_	28	acl:relcl	_	_
39	of	of	IN	IN	_	40	case	_	_
40	growth	growth	NN	NN	_	38	nmod	_	_
41	,	,	,	,	_	38	punct	_	_
42	respectively	respectively	RB	RB	_	38	advmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Treatment	treatment	NN	NN	_	24	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	erythrocytes	erythrocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	9	case	_	_
6	10	10	CD	CD	_	7	compound	_	_
7	microM	microm	NN	NN	_	9	amod	_	_
8	sodium	sodium	NN	NN	_	9	compound	_	_
9	orthovanadate	orthovanadate	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NaOV	naov	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	an	a	DT	DT	_	15	det	_	_
15	inhibitor	inhibitor	NN	NN	_	9	appos	_	_
16	of	of	IN	IN	_	19	case	_	_
17	plasma	plasma	NN	NN	_	19	compound	_	_
18	membrane	membrane	NN	NN	_	19	compound	_	_
19	Ca-ATPase	ca-atpase	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	phosphotyrosine	phosphotyrosine	NN	NN	_	22	compound	_	_
22	phosphatase	phosphatase	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	9	punct	_	_
24	decreased	decrease	VBD	VBD	_	0	root	_	_
25	parasitemia	parasitemia	NN	NN	_	24	dobj	_	_
26	by	by	IN	IN	_	28	case	_	_
27	30	30	CD	CD	_	28	nummod	_	_
28	%	%	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	24	punct	_	_

1	Co-treatment	co-treatment	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	RBCs	rbc	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	TCDD	tcdd	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	NaOV	naov	NN	NN	_	5	conj	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	blocked	block	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TCDD-induced	tcdd-induced	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	parasitemia	parasitemia	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	4	mark	_	_
2	erythrocytes	erythrocyte	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	aux	_	_
4	anucleated	anucleated	JJ	JJ	_	9	advcl	_	_
5	,	,	,	,	_	9	punct	_	_
6	these	these	DT	DT	_	7	det	_	_
7	results	result	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	discussed	discuss	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	11	case	_	_
11	evidence	evidence	NN	NN	_	9	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	biochemical	biochemical	JJ	JJ	_	14	amod	_	_
14	changes	change	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	TCDD	tcdd	NN	NN	_	14	nmod	_	_
17	without	without	IN	IN	_	18	mark	_	_
18	requiring	require	VBG	VBG	_	14	acl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activation	activation	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	products	product	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	trans-activation	trans-activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	cDNA	cdna	NN	NN	_	1	nmod	_	_
9	and	and	CC	CC	_	1	cc	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	clones	clone	NNS	NNS	_	1	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	herpesvirus-6	herpesvirus-6	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	herpesvirus	herpesvirus	NN	NN	_	10	nsubj	_	_
3	6	6	CD	CD	_	2	nummod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	HHV-6	hhv-6	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	lymphotropic	lymphotropic	JJ	JJ	_	10	amod	_	_
10	herpesvirus	herpesvirus	NN	NN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	19	advmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	it	it	PRP	PRP	_	19	nsubj	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	productively	productively	RB	RB	_	19	advmod	_	_
19	infect	infect	VB	VB	_	10	conj	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	CD4+	cd4+	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	dobj	_	_
24	as	as	IN	IN	_	25	case	_	_
25	HIV-1	hiv-1	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Co-infection	co-infection	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	HIV-1	hiv-1	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	HHV-6	hhv-6	NN	NN	_	6	conj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	lead	lead	VB	VB	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	acceleration	acceleration	NN	NN	_	13	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cytopathic	cytopathic	JJ	JJ	_	23	amod	_	_
23	effects	effect	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	An	a	DT	DT	_	7	det	_	_
2	HHV-6	hhv-6	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	GS	gs	NN	NN	_	7	compound	_	_
5	)	)	-RRB-	-RRB-	_	7	punct	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	clone	clone	NN	NN	_	18	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	pCD41	pcd41	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	encoding	encode	VBG	VBG	_	7	acl	_	_
12	for	for	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	41-kDa	41-kda	JJ	JJ	_	16	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	11	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	identified	identify	VBN	VBN	_	0	root	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	characterized	characterize	VBN	VBN	_	18	conj	_	_
21	previously	previously	RB	RB	_	18	advmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	Chang	Chang	NNP	NNP	_	18	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Balachandran	Balachandran	NNP	NNP	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	J.	J.	NNP	NNP	_	28	compound	_	_
28	Virol	Virol	NNP	NNP	_	23	appos	_	_
29	.	.	.	.	_	28	punct	_	_
30	65	65	CD	CD	_	28	nummod	_	_
31	,	,	,	,	_	23	punct	_	_
32	2884-2894	2884-2894	CD	CD	_	23	appos	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	7085	7085	CD	CD	_	32	conj	_	_
35	,	,	,	,	_	23	punct	_	_
36	1991	1991	CD	CD	_	23	amod	_	_
37	)	)	-RRB-	-RRB-	_	23	punct	_	_
38	.	.	.	.	_	18	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	3	ccomp	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	homology	homology	NN	NN	_	7	dobj	_	_
10	with	with	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	cytomegalovirus	cytomegalovirus	NN	NN	_	15	compound	_	_
14	UL44	ul44	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	9	nmod	_	_
16	coding	code	VBG	VBG	_	15	acl	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	ICP36	icp36	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	early-late-class	early-late-class	JJ	JJ	_	23	amod	_	_
23	phosphoprotein	phosphoprotein	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	this	this	DT	DT	_	3	det	_	_
3	cDNA	cdna	NN	NN	_	1	dobj	_	_
4	as	as	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	probe	probe	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	a	a	DT	DT	_	12	det	_	_
9	3.8-kb	3.8-kb	JJ	JJ	_	12	amod	_	_
10	EcoRI	ecori	NN	NN	_	12	compound	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	fragment	fragment	NN	NN	_	21	nsubjpass	_	_
13	encoding	encode	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	19	det	_	_
15	HHV-6	hhv-6	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	GS	gs	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	P41	p41	NN	NN	_	13	dobj	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	cloned	clone	VBN	VBN	_	1	parataxis	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	designated	designate	VBN	VBN	_	21	conj	_	_
24	as	as	IN	IN	_	25	case	_	_
25	pGD41	pgd41	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	cotransfected	cotransfect	VBN	VBN	_	18	advcl	_	_
3	with	with	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	HIV	hiv	NN	NN	_	7	compound	_	_
6	LTR	ltr	NN	NN	_	7	compound	_	_
7	CAT	cat	NN	NN	_	2	nmod	_	_
8	into	into	IN	IN	_	10	case	_	_
9	CV-1	cv-1	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	pCD41	pcd41	NN	NN	_	18	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	pGD41	pgd41	NN	NN	_	14	conj	_	_
17	clones	clone	NNS	NNS	_	14	dep	_	_
18	trans-activated	trans-activate	VBD	VBD	_	0	root	_	_
19	the	the	DT	DT	_	21	det	_	_
20	HIV	hiv	NN	NN	_	21	compound	_	_
21	LTR	ltr	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	18	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	pCD41	pcd41	NN	NN	_	2	nmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	are	be	VBP	VBP	_	5	ccomp	_	_
9	two	two	CD	CD	_	13	nummod	_	_
10	potential	potential	JJ	JJ	_	13	amod	_	_
11	open	open	JJ	JJ	_	13	amod	_	_
12	reading	reading	NN	NN	_	13	compound	_	_
13	frames	frame	NNS	NNS	_	8	nsubj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	ORFs	orf	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	A	a	NN	NN	_	13	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	B	b	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	13	punct	_	_
22	which	which	WDT	WDT	_	24	nsubj	_	_
23	are	be	VBP	VBP	_	24	cop	_	_
24	homologous	homologous	JJ	JJ	_	13	acl:relcl	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	ORFs	orf	NNS	NNS	_	24	nmod	_	_
28	found	find	VBN	VBN	_	27	acl	_	_
29	in	in	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	genomic	genomic	JJ	JJ	_	33	amod	_	_
32	clone	clone	NN	NN	_	33	compound	_	_
33	pGD41	pgd41	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	constructs	construct	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	pCD41	pcd41	NN	NN	_	6	compound	_	_
6	clone	clone	NN	NN	_	2	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	ORF-A	orf-a	NN	NN	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	critical	critical	JJ	JJ	_	7	ccomp	_	_
12	for	for	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	HIV	hiv	NN	NN	_	16	compound	_	_
15	LTR	ltr	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	pCD41	pcd41	NN	NN	_	6	compound	_	_
6	ORF-A	orf-a	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	the	the	DT	DT	_	9	det	_	_
9	use	use	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	constructs	construct	NNS	NNS	_	9	nmod	_	_
13	further	further	RB	RB	_	14	advmod	_	_
14	mapped	map	VBD	VBD	_	0	root	_	_
15	an	a	DT	DT	_	18	det	_	_
16	internal	internal	JJ	JJ	_	18	amod	_	_
17	functional	functional	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	14	dobj	_	_
19	within	within	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	pCD41	pcd41	NN	NN	_	22	compound	_	_
22	sequence	sequence	NN	NN	_	14	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	direct	direct	VB	VB	_	22	acl:relcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	synthesis	synthesis	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	trans-activating	trans-activating	JJ	JJ	_	31	amod	_	_
31	protein	protein	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	14	advcl	_	_
3	HIV	hiv	NN	NN	_	6	compound	_	_
4	LTR	ltr	NN	NN	_	6	compound	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	mutants	mutant	NNS	NNS	_	2	dobj	_	_
7	,	,	,	,	_	14	punct	_	_
8	the	the	DT	DT	_	12	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	critical	critical	JJ	JJ	_	14	xcomp	_	_
18	for	for	IN	IN	_	19	case	_	_
19	response	response	NN	NN	_	17	nmod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	pCD41	pcd41	NN	NN	_	23	compound	_	_
23	trans-activation	trans-activation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	gelatinase	gelatinase	NN	NN	_	6	compound	_	_
6	granules	granule	NNS	NNS	_	1	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	neutrophils	neutrophil	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	confirmed	confirm	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	existence	existence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	gelatinase	gelatinase	NN	NN	_	8	compound	_	_
8	granules	granule	NNS	NNS	_	5	nmod	_	_
9	as	as	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	subpopulation	subpopulation	NN	NN	_	3	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	peroxidase-negative	peroxidase-negative	JJ	JJ	_	14	amod	_	_
14	granules	granule	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	19	case	_	_
16	double-labeling	double-labeling	JJ	JJ	_	19	amod	_	_
17	immunogold	immunogold	JJ	JJ	_	19	amod	_	_
18	electron	electron	NN	NN	_	19	compound	_	_
19	microscopy	microscopy	NN	NN	_	3	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	intact	intact	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	by	by	IN	IN	_	26	case	_	_
25	subcellular	subcellular	JJ	JJ	_	26	amod	_	_
26	fractionation	fractionation	NN	NN	_	19	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	characterization	characterization	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gelatinase	gelatinase	NN	NN	_	5	compound	_	_
5	granules	granule	NNS	NNS	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	hampered	hamper	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	poor	poor	JJ	JJ	_	11	amod	_	_
11	separation	separation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	specific	specific	JJ	JJ	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	gelatinase	gelatinase	NN	NN	_	13	conj	_	_
16	granules	granule	NNS	NNS	_	13	dep	_	_
17	on	on	IN	IN	_	21	case	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	two-layer	two-layer	JJ	JJ	_	21	amod	_	_
20	Percoll	percoll	NN	NN	_	21	compound	_	_
21	gradients	gradient	NNS	NNS	_	11	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	sucrose	sucrose	NN	NN	_	24	compound	_	_
24	gradients	gradient	NNS	NNS	_	21	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	three-layer	three-layer	JJ	JJ	_	8	amod	_	_
6	Percoll	percoll	NN	NN	_	8	compound	_	_
7	density	density	NN	NN	_	8	compound	_	_
8	gradient	gradient	NN	NN	_	3	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	allows	allow	VBZ	VBZ	_	8	acl:relcl	_	_
11	separation	separation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	dep	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	granules	granule	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	vesicles	vesicle	NNS	NNS	_	15	conj	_	_
18	from	from	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	neutrophils	neutrophil	NNS	NNS	_	11	nmod	_	_
21	;	;	:	:	_	3	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	particular	particular	JJ	JJ	_	26	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	it	it	PRP	PRP	_	26	nsubj	_	_
26	allows	allow	VBZ	VBZ	_	3	parataxis	_	_
27	separation	separation	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	specific	specific	JJ	JJ	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	gelatinase	gelatinase	NN	NN	_	29	conj	_	_
32	granules	granule	NNS	NNS	_	29	dep	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	allows	allow	VBZ	VBZ	_	0	root	_	_
3	us	we	PRP	PRP	_	2	dobj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	characterize	characterize	VB	VB	_	2	xcomp	_	_
6	these	these	DT	DT	_	9	det	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	granule	granule	NN	NN	_	9	compound	_	_
9	populations	population	NNS	NNS	_	5	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	regard	regard	NN	NN	_	5	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	content	content	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	membrane	membrane	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	become	become	VBP	VBP	_	17	acl:relcl	_	_
21	incorporated	incorporate	VBN	VBN	_	20	xcomp	_	_
22	into	into	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	plasma	plasma	NN	NN	_	25	compound	_	_
25	membrane	membrane	NN	NN	_	21	nmod	_	_
26	during	during	IN	IN	_	27	case	_	_
27	exocytosis	exocytosis	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	gelatinase	gelatinase	NN	NN	_	5	compound	_	_
5	granules	granule	NNS	NNS	_	17	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	defined	define	VBN	VBN	_	5	acl	_	_
8	as	as	IN	IN	_	10	case	_	_
9	peroxidase-negative	peroxidase-negative	JJ	JJ	_	10	amod	_	_
10	granules	granule	NNS	NNS	_	7	nmod	_	_
11	containing	contain	VBG	VBG	_	10	dep	_	_
12	gelatinase	gelatinase	NN	NN	_	11	dobj	_	_
13	but	but	CC	CC	_	11	cc	_	_
14	lacking	lack	VBG	VBG	_	11	conj	_	_
15	lactoferrin	lactoferrin	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	5	punct	_	_
17	contain	contain	VBP	VBP	_	2	ccomp	_	_
18	50	50	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	total	total	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	gelatinase	gelatinase	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	with	with	IN	IN	_	28	mark	_	_
26	the	the	DT	DT	_	28	dep	_	_
27	remaining	remain	VBG	VBG	_	26	amod	_	_
28	residing	residing	NN	NN	_	17	advcl	_	_
29	in	in	IN	IN	_	31	case	_	_
30	specific	specific	JJ	JJ	_	31	amod	_	_
31	granules	granule	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	20	20	CD	CD	_	10	nummod	_	_
7	%	%	NN	NN	_	10	compound	_	_
8	to	to	TO	TO	_	10	dep	_	_
9	25	25	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	24	nsubj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	both	both	DT	DT	_	16	cc:preconj	_	_
13	the	the	DT	DT	_	16	det	_	_
14	adhesion	adhesion	NN	NN	_	16	compound	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	Mac-1	mac-1	NN	NN	_	10	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	NADPH-oxidase	nadph-oxidase	NN	NN	_	21	compound	_	_
20	component	component	NN	NN	_	21	compound	_	_
21	cytochrome	cytochrome	NN	NN	_	16	conj	_	_
22	b558	b558	NN	NN	_	21	dep	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	localized	localized	JJ	JJ	_	4	ccomp	_	_
25	in	in	IN	IN	_	27	case	_	_
26	gelatinase	gelatinase	NN	NN	_	27	compound	_	_
27	granules	granule	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	no	no	DT	DT	_	4	neg	_	_
3	qualitative	qualitative	JJ	JJ	_	4	amod	_	_
4	difference	difference	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	27	advcl	_	_
7	between	between	IN	IN	_	9	case	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	granules	granule	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	gelatinase	gelatinase	NN	NN	_	12	compound	_	_
12	granules	granule	NNS	NNS	_	9	conj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	respect	respect	NN	NN	_	6	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	cytochrome	cytochrome	NN	NN	_	17	compound	_	_
17	b558	b558	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Mac-1	mac-1	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	27	punct	_	_
21	stimulation	stimulation	NN	NN	_	27	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	neutrophil	neutrophil	NN	NN	_	21	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	FMLP	fmlp	NN	NN	_	21	nmod	_	_
27	resulted	result	VBD	VBD	_	0	root	_	_
28	in	in	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	selective	selective	JJ	JJ	_	31	amod	_	_
31	mobilization	mobilization	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	least	least	RBS	RBS	_	36	advmod	_	_
35	dense	dense	JJ	JJ	_	36	amod	_	_
36	peroxidase-negative	peroxidase-negative	JJ	JJ	_	37	amod	_	_
37	granules	granule	NNS	NNS	_	31	nmod	_	_
38	,	,	,	,	_	37	punct	_	_
39	ie	ie	FW	FW	_	37	acl	_	_
40	,	,	,	,	_	37	punct	_	_
41	gelatinase	gelatinase	NN	NN	_	42	compound	_	_
42	granules	granule	NNS	NNS	_	37	appos	_	_
43	,	,	,	,	_	42	punct	_	_
44	which	which	WDT	WDT	_	52	nsubj	_	_
45	,	,	,	,	_	52	punct	_	_
46	in	in	IN	IN	_	47	case	_	_
47	concert	concert	NN	NN	_	52	nmod	_	_
48	with	with	IN	IN	_	50	case	_	_
49	secretory	secretory	JJ	JJ	_	50	amod	_	_
50	vesicles	vesicle	NNS	NNS	_	47	nmod	_	_
51	,	,	,	,	_	52	punct	_	_
52	furnish	furnish	VBP	VBP	_	42	acl:relcl	_	_
53	the	the	DT	DT	_	55	det	_	_
54	plasma	plasma	NN	NN	_	55	compound	_	_
55	membrane	membrane	NN	NN	_	52	dobj	_	_
56	with	with	IN	IN	_	57	case	_	_
57	Mac-1	mac-1	NN	NN	_	52	nmod	_	_
58	and	and	CC	CC	_	57	cc	_	_
59	cytochrome	cytochrome	NN	NN	_	60	compound	_	_
60	b558	b558	NN	NN	_	57	conj	_	_
61	.	.	.	.	_	27	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	shows	show	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	gelatinase	gelatinase	NN	NN	_	5	compound	_	_
5	granules	granule	NNS	NNS	_	8	nsubj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	functionally	functionally	RB	RB	_	8	advmod	_	_
8	important	important	JJ	JJ	_	2	ccomp	_	_
9	relative	relative	JJ	JJ	_	8	xcomp	_	_
10	to	to	TO	TO	_	12	case	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	granules	granule	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	mediating	mediate	VBG	VBG	_	8	advcl	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	inflammatory	inflammatory	JJ	JJ	_	15	dep	_	_
17	responses	response	NNS	NNS	_	14	dobj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Stress	stress	NN	NN	_	2	compound	_	_
2	response	response	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	senescent	senescent	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	:	:	:	:	_	2	punct	_	_
8	reduced	reduce	VBN	VBN	_	9	amod	_	_
9	hsp70	hsp70	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	independent	independent	JJ	JJ	_	2	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	proliferative	proliferative	JJ	JJ	_	15	amod	_	_
15	block	block	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Senescent	senescent	JJ	JJ	_	5	amod	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	cultures	culture	NNS	NNS	_	7	nsubj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	unable	unable	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	undergo	undergo	VB	VB	_	7	xcomp	_	_
10	proliferation	proliferation	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	but	but	CC	CC	_	7	cc	_	_
13	show	show	VBP	VBP	_	7	conj	_	_
14	no	no	DT	DT	_	15	neg	_	_
15	difference	difference	NN	NN	_	13	dobj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	early	early	JJ	JJ	_	19	amod	_	_
18	passage	passage	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	cytotoxic	cytotoxic	JJ	JJ	_	22	amod	_	_
22	function	function	NN	NN	_	19	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	surface	surface	NN	NN	_	26	compound	_	_
25	antigenic	antigenic	JJ	JJ	_	26	amod	_	_
26	profile	profile	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	feature	feature	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	senescent	senescent	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	the	the	DT	DT	_	11	det	_	_
10	dramatic	dramatic	JJ	JJ	_	11	amod	_	_
11	reduction	reduction	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	hsp70	hsp70	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	response	response	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	heat	heat	NN	NN	_	19	compound	_	_
19	shock	shock	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	decline	decline	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	decrease	decrease	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	binding	binding	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	extracts	extract	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	consensus	consensus	NN	NN	_	18	compound	_	_
16	heat	heat	NN	NN	_	18	compound	_	_
17	shock	shock	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Interestingly	interestingly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	progressive	progressive	JJ	JJ	_	5	amod	_	_
5	decline	decline	NN	NN	_	15	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	heat	heat	NN	NN	_	10	compound	_	_
9	shock	shock	NN	NN	_	10	compound	_	_
10	response	response	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	cultured	culture	VBD	VBD	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	5	nmod	_	_
15	correlates	correlate	VBZ	VBZ	_	0	root	_	_
16	with	with	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	percent	percent	JJ	JJ	_	21	amod	_	_
19	proliferative	proliferative	JJ	JJ	_	21	amod	_	_
20	life	life	NN	NN	_	21	compound	_	_
21	span	span	NN	NN	_	15	nmod	_	_
22	completed	complete	VBN	VBN	_	21	acl	_	_
23	rather	rather	RB	RB	_	21	cc	_	_
24	than	than	IN	IN	_	23	mwe	_	_
25	with	with	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	actual	actual	JJ	JJ	_	29	amod	_	_
28	proliferative	proliferative	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	21	conj	_	_
30	at	at	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	time	time	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	heat	heat	NN	NN	_	35	compound	_	_
35	shock	shock	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	33	mark	_	_
4	for	for	IN	IN	_	7	case	_	_
5	senescent	senescent	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	33	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	reduced	reduce	VBN	VBN	_	10	amod	_	_
10	ability	ability	NN	NN	_	33	nsubj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	respond	respond	VB	VB	_	10	acl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	heat	heat	NN	NN	_	15	compound	_	_
15	shock	shock	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	producing	produce	VBG	VBG	_	12	advcl	_	_
18	hsp70	hsp70	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	10	punct	_	_
20	although	although	IN	IN	_	22	mark	_	_
21	possibly	possibly	RB	RB	_	22	advmod	_	_
22	lying	lie	VBG	VBG	_	33	dep	_	_
23	at	at	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	level	level	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	control	control	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	33	punct	_	_
30	may	may	MD	MD	_	33	aux	_	_
31	nevertheless	nevertheless	RB	RB	_	33	advmod	_	_
32	be	be	VB	VB	_	33	cop	_	_
33	unrelated	unrelated	JJ	JJ	_	2	ccomp	_	_
34	to	to	TO	TO	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	reduced	reduce	VBN	VBN	_	38	amod	_	_
37	DNA	dna	NN	NN	_	38	compound	_	_
38	synthesis	synthesis	NN	NN	_	33	nmod	_	_
39	or	or	CC	CC	_	38	cc	_	_
40	the	the	DT	DT	_	43	det	_	_
41	diminished	diminish	VBN	VBN	_	43	amod	_	_
42	proliferative	proliferative	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	38	conj	_	_
44	also	also	RB	RB	_	38	advmod	_	_
45	manifested	manifest	VBN	VBN	_	38	acl	_	_
46	by	by	IN	IN	_	48	case	_	_
47	these	these	DT	DT	_	48	det	_	_
48	cells	cell	NNS	NNS	_	45	nmod	_	_
49	.	.	.	.	_	2	punct	_	_

1	Thrombin	thrombin	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	thrombin	thrombin	NN	NN	_	6	compound	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	agonist	agonist	NN	NN	_	6	compound	_	_
6	peptide	peptide	NN	NN	_	1	conj	_	_
7	induce	induce	VBP	VBP	_	0	root	_	_
8	early	early	JJ	JJ	_	9	amod	_	_
9	events	event	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	synergize	synergize	VBP	VBP	_	7	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	TCR	tcr	NN	NN	_	18	compound	_	_
18	cross-linking	cross-linking	NN	NN	_	15	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	CD69	cd69	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	interleukin	interleukin	NN	NN	_	25	compound	_	_
24	2	2	CD	CD	_	25	nummod	_	_
25	production	production	NN	NN	_	21	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	T	t	NN	NN	_	9	compound	_	_
6	leukemic	leukemic	JJ	JJ	_	9	amod	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	line	line	NN	NN	_	9	compound	_	_
9	Jurkat	jurkat	NN	NN	_	2	nmod	_	_
10	induced	induce	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	transient	transient	JJ	JJ	_	13	amod	_	_
13	increase	increase	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Proteolytic	proteolytic	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	enzyme	enzyme	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	7	nmod	_	_
11	since	since	IN	IN	_	14	mark	_	_
12	diisopropyl	diisopropyl	NN	NN	_	13	compound	_	_
13	fluorophosphate-thrombin	fluorophosphate-thrombin	NN	NN	_	14	nsubj	_	_
14	failed	fail	VBD	VBD	_	7	advcl	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	increase	increase	VB	VB	_	14	xcomp	_	_
17	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	16	dobj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	hirudin	hirudin	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	anti-thrombin	anti-thrombin	NN	NN	_	3	conj	_	_
6	III	iii	CD	CD	_	5	nummod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	thrombin-induced	thrombin-induced	JJ	JJ	_	11	amod	_	_
10	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	11	compound	_	_
11	rise	rise	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	Jurkat	jurkat	NN	NN	_	15	compound	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	synthetic	synthetic	JJ	JJ	_	6	amod	_	_
3	thrombin	thrombin	NN	NN	_	6	compound	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	agonist	agonist	NN	NN	_	6	compound	_	_
6	peptide	peptide	NN	NN	_	17	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TRP	trp	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	12	case	_	_
11	7	7	CD	CD	_	12	nummod	_	_
12	residues	residue	NNS	NNS	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SFLLRNP	sfllrnp	NN	NN	_	6	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	21	mark	_	_
19	be	be	VB	VB	_	21	cop	_	_
20	as	as	RB	RB	_	21	advmod	_	_
21	effective	effective	JJ	JJ	_	17	xcomp	_	_
22	as	as	IN	IN	_	23	case	_	_
23	thrombin	thrombin	NN	NN	_	21	nmod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	26	compound	_	_
26	mobilization	mobilization	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	both	both	DT	DT	_	30	det	_	_
30	agonists	agonist	NNS	NNS	_	31	nsubj	_	_
31	induced	induce	VBD	VBD	_	17	conj	_	_
32	Ca2+	ca2+	NN	NN	_	33	compound	_	_
33	release	release	NN	NN	_	31	dobj	_	_
34	exclusively	exclusively	RB	RB	_	31	advmod	_	_
35	from	from	IN	IN	_	37	case	_	_
36	internal	internal	JJ	JJ	_	37	amod	_	_
37	stores	store	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	17	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	several	several	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	mass	mass	NN	NN	_	7	nmod	_	_
11	40	40	CD	CD	_	10	dep	_	_
12	,	,	,	,	_	10	punct	_	_
13	42	42	CD	CD	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	70	70	CD	CD	_	10	conj	_	_
16	,	,	,	,	_	10	punct	_	_
17	120	120	CD	CD	_	10	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	130	130	CD	CD	_	10	conj	_	_
21	kDa	kda	NN	NN	_	10	dep	_	_
22	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	good	good	JJ	JJ	_	5	amod	_	_
5	correlation	correlation	NN	NN	_	2	nsubj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	thrombin-induced	thrombin-induced	JJ	JJ	_	9	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	latter	latter	JJ	JJ	_	14	amod	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	proteins	protein	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	Ca2+	ca2+	NN	NN	_	17	compound	_	_
17	mobilization	mobilization	NN	NN	_	9	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Thrombin	thrombin	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	TRP	trp	NN	NN	_	1	conj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	caused	cause	VBD	VBD	_	0	root	_	_
6	translocation	translocation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	6	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytosol	cytosol	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	plasma	plasma	NN	NN	_	17	compound	_	_
17	membrane	membrane	NN	NN	_	5	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	likely	likely	JJ	JJ	_	4	amod	_	_
4	consequence	consequence	NN	NN	_	10	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	events	event	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	thrombin	thrombin	NN	NN	_	10	nsubj	_	_
10	activated	activate	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	NF-kB	nf-kb	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	21	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	hematopoietic	hematopoietic	JJ	JJ	_	6	amod	_	_
6	origin	origin	NN	NN	_	3	nmod	_	_
7	including	include	VBG	VBG	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	leukemic	leukemic	JJ	JJ	_	13	amod	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	line	line	NN	NN	_	13	compound	_	_
13	HPB.ALL	hpb.all	NN	NN	_	3	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	19	det	_	_
16	erythroleukemic	erythroleukemic	JJ	JJ	_	19	amod	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	line	line	NN	NN	_	19	compound	_	_
19	K562	k562	NN	NN	_	13	conj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	responsive	responsive	JJ	JJ	_	0	root	_	_
22	to	to	TO	TO	_	23	case	_	_
23	thrombin	thrombin	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	whereas	whereas	IN	IN	_	43	mark	_	_
26	others	other	NNS	NNS	_	43	nsubj	_	_
27	such	such	JJ	JJ	_	29	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	THP1	thp1	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	a	a	DT	DT	_	34	det	_	_
32	myelomonocytic	myelomonocytic	JJ	JJ	_	34	amod	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	line	line	NN	NN	_	29	appos	_	_
35	,	,	,	,	_	29	punct	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	BL2	bl2	NN	NN	_	29	conj	_	_
38	,	,	,	,	_	37	punct	_	_
39	a	a	DT	DT	_	41	det	_	_
40	Burkitt	burkitt	NN	NN	_	41	compound	_	_
41	lymphoma	lymphoma	NN	NN	_	37	appos	_	_
42	were	be	VBD	VBD	_	43	cop	_	_
43	refractory	refractory	JJ	JJ	_	21	advcl	_	_
44	to	to	TO	TO	_	45	case	_	_
45	thrombin	thrombin	NN	NN	_	43	nmod	_	_
46	or	or	CC	CC	_	45	cc	_	_
47	TRP	trp	NN	NN	_	45	conj	_	_
48	stimulation	stimulation	NN	NN	_	45	dep	_	_
49	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	thrombin	thrombin	NN	NN	_	6	compound	_	_
6	response	response	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	types	type	NNS	NNS	_	6	nmod	_	_
12	paralleled	parallel	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	thrombin	thrombin	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	mRNA	mrna	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	activation	activation	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	Jurkat	jurkat	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	combination	combination	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	phytohemagglutinin	phytohemagglutinin	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	phorbol	phorbol	NN	NN	_	17	compound	_	_
16	12-myristate	12-myristate	NN	NN	_	17	compound	_	_
17	13-acetate	13-acetate	NN	NN	_	13	conj	_	_
18	led	lead	VBD	VBD	_	2	ccomp	_	_
19	to	to	TO	TO	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	dramatic	dramatic	JJ	JJ	_	22	amod	_	_
22	inhibition	inhibition	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	thrombin	thrombin	NN	NN	_	27	compound	_	_
25	receptor	receptor	NN	NN	_	27	compound	_	_
26	mRNA	mrna	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	22	nmod	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	to	to	TO	TO	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	concomitant	concomitant	JJ	JJ	_	32	amod	_	_
32	loss	loss	NN	NN	_	22	conj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	thrombin	thrombin	NN	NN	_	36	compound	_	_
36	response	response	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	thrombin	thrombin	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TRP	trp	NN	NN	_	6	conj	_	_
9	enhanced	enhance	VBD	VBD	_	4	ccomp	_	_
10	CD69	cd69	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	interleukin	interleukin	NN	NN	_	15	compound	_	_
14	2	2	CD	CD	_	15	nummod	_	_
15	production	production	NN	NN	_	11	conj	_	_
16	induced	induce	VBN	VBN	_	11	acl	_	_
17	by	by	IN	IN	_	21	case	_	_
18	T	t	NN	NN	_	21	compound	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	cross-linking	cross-linking	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	both	both	CC	CC	_	26	cc:preconj	_	_
24	Jurkat	jurkat	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	peripheral	peripheral	JJ	JJ	_	30	amod	_	_
29	blood	blood	NN	NN	_	30	compound	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	highlight	highlight	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	thrombin	thrombin	NN	NN	_	5	nmod	_	_
8	as	as	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potential	potential	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	3	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	dep	_	_
2	interleukin-8	interleukin-8	NN	NN	_	3	compound	_	_
3	AP-1	ap-1	NN	NN	_	11	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	kappa	kappa	NN	NN	_	3	conj	_	_
6	B-like	b-like	JJ	JJ	_	5	amod	_	_
7	sites	site	NNS	NNS	_	3	dep	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	genetic	genetic	JJ	JJ	_	11	amod	_	_
10	end	end	NN	NN	_	11	compound	_	_
11	targets	target	NNS	NNS	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	FK506-sensitive	fk506-sensitive	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	11	nmod	_	_
15	accompanied	accompany	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	calcium	calcium	NN	NN	_	18	compound	_	_
18	mobilization	mobilization	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	FK506	fk506	NN	NN	_	6	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	immunosuppressant	immunosuppressant	NN	NN	_	1	appos	_	_
5	,	,	,	,	_	1	punct	_	_
6	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	production	production	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	FK506	fk506	NN	NN	_	5	nsubj	_	_
5	suppressed	suppress	VBD	VBD	_	2	ccomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	transcription	transcription	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	chemotactic	chemotactic	JJ	JJ	_	11	amod	_	_
11	cytokine	cytokine	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	interleukin-8	interleukin-8	NN	NN	_	11	appos	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL-8	il-8	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	11	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	Jurkat	jurkat	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	appos	_	_
26	,	,	,	,	_	22	punct	_	_
27	activated	activate	VBN	VBN	_	22	acl	_	_
28	by	by	IN	IN	_	31	case	_	_
29	phorbol	phorbol	NN	NN	_	31	compound	_	_
30	12-myristate	12-myristate	NN	NN	_	31	compound	_	_
31	13-acetate	13-acetate	NN	NN	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	PMA	pma	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	calcium	calcium	NN	NN	_	31	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	Ca2+	ca2+	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	ionophore	ionophore	NN	NN	_	36	dep	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	ionomycin	ionomycin	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	2	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	deleted	deleted	JJ	JJ	_	18	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mutated	mutate	VBN	VBN	_	2	conj	_	_
5	analysis	analysis	NN	NN	_	2	dep	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-8	il-8	NN	NN	_	9	compound	_	_
9	promoters	promoter	NNS	NNS	_	2	nmod	_	_
10	,	,	,	,	_	18	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	AP-1	ap-1	NN	NN	_	18	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B-like	b-like	JJ	JJ	_	16	amod	_	_
16	sites	site	NNS	NNS	_	12	conj	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	identified	identify	VBN	VBN	_	0	root	_	_
19	as	as	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	responsive	responsive	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	18	nmod	_	_
23	for	for	IN	IN	_	24	case	_	_
24	PMA	pma	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	ionomycin	ionomycin	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	18	punct	_	_

1	FK506	fk506	NN	NN	_	2	nsubj	_	_
2	suppressed	suppress	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	transcriptions	transcription	NNS	NNS	_	2	dobj	_	_
5	through	through	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	AP-1	ap-1	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B-like	b-like	JJ	JJ	_	11	amod	_	_
11	sites	site	NNS	NNS	_	7	conj	_	_
12	induced	induce	VBN	VBN	_	4	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	PMA	pma	NN	NN	_	12	nmod	_	_
15	plus	plus	CC	CC	_	14	cc	_	_
16	Ca(2+)-mobilizing	ca(2+)-mobilizing	NN	NN	_	17	compound	_	_
17	agents	agent	NNS	NNS	_	14	conj	_	_
18	,	,	,	,	_	4	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	4	cc	_	_
21	those	those	DT	DT	_	4	conj	_	_
22	induced	induce	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	Ca(2+)-independent	ca(2+)-independent	NN	NN	_	25	compound	_	_
25	stimuli	stimulus	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	gel	gel	NN	NN	_	4	compound	_	_
3	retardation	retardation	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	FK506	fk506	NN	NN	_	7	nsubj	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	little	little	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	binding	binding	NN	NN	_	7	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	PMA/ionomycin-induced	pma/ionomycin-induced	JJ	JJ	_	20	amod	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	factors	factor	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	nsubjpass	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	recognized	recognize	VBN	VBN	_	20	acl:relcl	_	_
25	with	with	IN	IN	_	26	case	_	_
26	anti-JunD	anti-jund	JJ	JJ	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	c-Fos	c-fos	NN	NN	_	29	compound	_	_
29	antibody	antibody	NN	NN	_	26	conj	_	_
30	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	FK506	fk506	NN	NN	_	12	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	EGTA	egta	NN	NN	_	4	conj	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	Ca2+	ca2+	NN	NN	_	9	compound	_	_
9	chelator	chelator	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	similarly	similarly	RB	RB	_	12	advmod	_	_
12	affected	affect	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	formation	formation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	kappa	kappa	NN	NN	_	20	compound	_	_
17	B-like	b-like	JJ	JJ	_	20	amod	_	_
18	site	site	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	complexes	complex	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	25	nsubjpass	_	_
23	were	be	VBD	VBD	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	recognized	recognize	VBN	VBN	_	20	acl:relcl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	any	any	DT	DT	_	28	det	_	_
28	antibodies	antibody	NNS	NNS	_	25	nmod	_	_
29	against	against	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	human	human	JJ	JJ	_	34	amod	_	_
32	Rel	rel	NN	NN	_	34	compound	_	_
33	family	family	NN	NN	_	34	compound	_	_
34	proteins	protein	NNS	NNS	_	28	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	c-Rel	c-rel	NN	NN	_	34	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	p65	p65	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	p50	p50	NN	NN	_	36	conj	_	_
41	,	,	,	,	_	36	punct	_	_
42	and	and	CC	CC	_	36	cc	_	_
43	p49	p49	NN	NN	_	36	conj	_	_
44	)	)	-RRB-	-RRB-	_	36	punct	_	_
45	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	confirmed	confirm	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	previous	previous	JJ	JJ	_	7	amod	_	_
7	report	report	NN	NN	_	4	dobj	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	FK506	fk506	NN	NN	_	10	nsubj	_	_
10	suppressed	suppress	VBD	VBD	_	7	ccomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	PMA/ionomycin-induced	pma/ionomycin-induced	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	10	dobj	_	_
14	through	through	IN	IN	_	18	case	_	_
15	authentic	authentic	JJ	JJ	_	18	amod	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	Ig	ig	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	gene	gene	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	to	to	TO	TO	_	27	case	_	_
27	which	which	WDT	WDT	_	33	nmod	_	_
28	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	binding	binding	NN	NN	_	33	nsubjpass	_	_
31	was	be	VBD	VBD	_	33	auxpass	_	_
32	also	also	RB	RB	_	33	advmod	_	_
33	decreased	decrease	VBN	VBN	_	24	acl:relcl	_	_
34	by	by	IN	IN	_	35	case	_	_
35	FK506	fk506	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	10	punct	_	_
37	indicating	indicate	VBG	VBG	_	10	advcl	_	_
38	that	that	IN	IN	_	50	mark	_	_
39	both	both	CC	CC	_	43	cc:preconj	_	_
40	IL-8	il-8	NN	NN	_	43	compound	_	_
41	kappa	kappa	NN	NN	_	43	compound	_	_
42	B-like	b-like	JJ	JJ	_	43	amod	_	_
43	site	site	NN	NN	_	50	nsubj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	Ig	ig	NN	NN	_	48	compound	_	_
46	kappa	kappa	NN	NN	_	48	compound	_	_
47	B	b	NN	NN	_	48	compound	_	_
48	site	site	NN	NN	_	43	conj	_	_
49	are	be	VBP	VBP	_	50	cop	_	_
50	FK506-sensitive	fk506-sensitive	JJ	JJ	_	37	ccomp	_	_
51	in	in	IN	IN	_	52	case	_	_
52	spite	spite	NN	NN	_	50	nmod	_	_
53	of	of	IN	IN	_	55	case	_	_
54	the	the	DT	DT	_	55	det	_	_
55	difference	difference	NN	NN	_	52	nmod	_	_
56	of	of	IN	IN	_	58	case	_	_
57	binding	binding	JJ	JJ	_	58	amod	_	_
58	factors	factor	NNS	NNS	_	55	nmod	_	_
59	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	30	mark	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	only	only	RB	RB	_	10	cc:preconj	_	_
7	the	the	DT	DT	_	10	dep	_	_
8	reported	report	VBN	VBN	_	10	amod	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	NF-AT	nf-at	NN	NN	_	30	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NFIL-2A	nfil-2a	NN	NN	_	10	conj	_	_
13	sites	site	NNS	NNS	_	10	dep	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	Ig	ig	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	but	but	CC	CC	_	10	cc	_	_
21	also	also	RB	RB	_	23	advmod	_	_
22	the	the	DT	DT	_	23	det	_	_
23	IL-8	il-8	NN	NN	_	10	conj	_	_
24	AP-1	ap-1	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	23	cc	_	_
26	kappa	kappa	NN	NN	_	28	compound	_	_
27	B-like	b-like	JJ	JJ	_	28	amod	_	_
28	sites	site	NNS	NNS	_	23	conj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	terminals	terminal	NNS	NNS	_	3	ccomp	_	_
31	of	of	IN	IN	_	33	case	_	_
32	FK506-sensitive	fk506-sensitive	JJ	JJ	_	33	amod	_	_
33	pathway	pathway	NN	NN	_	30	nmod	_	_
34	involving	involve	VBG	VBG	_	33	acl	_	_
35	Ca2+	ca2+	NN	NN	_	36	compound	_	_
36	mobilization	mobilization	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	interleukin	interleukin	NN	NN	_	6	compound	_	_
5	6	6	CD	CD	_	6	nummod	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	Mycobacterium	mycobacterium	NN	NN	_	9	compound	_	_
9	tuberculosis	tuberculosis	NN	NN	_	1	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	lipopolysaccharide	lipopolysaccharide	NN	NN	_	9	conj	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	17	case	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	factors	factor	NNS	NNS	_	17	compound	_	_
17	NF-IL6	nf-il6	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	conj	_	_
21	-LSB-	-lsb-	-LRB-	-LRB-	_	24	punct	_	_
22	published	publish	VBN	VBN	_	23	amod	_	_
23	erratum	erratum	NN	NN	_	24	nsubj	_	_
24	appears	appear	VBZ	VBZ	_	13	parataxis	_	_
25	in	in	IN	IN	_	32	case	_	_
26	Proc	Proc	NNP	NNP	_	32	compound	_	_
27	Natl	natl	NN	NN	_	32	compound	_	_
28	Acad	Acad	NNP	NNP	_	32	compound	_	_
29	Sci	Sci	NNP	NNP	_	32	compound	_	_
30	U	U	NNP	NNP	_	32	compound	_	_
31	S	S	NNP	NNP	_	32	compound	_	_
32	A	A	NNP	NNP	_	24	nmod	_	_
33	1995	1995	CD	CD	_	34	nummod	_	_
34	Apr	apr	NN	NN	_	32	dep	_	_
35	11	11	CD	CD	_	34	nummod	_	_
36	;	;	:	:	_	32	punct	_	_
37	92	92	CD	CD	_	42	nummod	_	_
38	(	(	-LRB-	-LRB-	_	42	punct	_	_
39	8	8	CD	CD	_	42	nummod	_	_
40	)	)	-RRB-	-RRB-	_	42	punct	_	_
41	:	:	:	:	_	42	punct	_	_
42	3632	3632	CD	CD	_	32	dep	_	_
43	-RSB-	-rsb-	-RRB-	-RRB-	_	24	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	host	host	NN	NN	_	3	compound	_	_
3	response	response	NN	NN	_	7	nsubj	_	_
4	to	to	TO	TO	_	6	case	_	_
5	Mycobacterium	mycobacterium	NN	NN	_	6	compound	_	_
6	tuberculosis	tuberculosis	NN	NN	_	3	nmod	_	_
7	includes	include	VBZ	VBZ	_	0	root	_	_
8	granuloma	granuloma	NN	NN	_	9	compound	_	_
9	formation	formation	NN	NN	_	7	dobj	_	_
10	at	at	IN	IN	_	11	case	_	_
11	sites	site	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	infection	infection	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	systemic	systemic	JJ	JJ	_	16	amod	_	_
16	symptoms	symptom	NNS	NNS	_	9	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	immunohistochemistry	immunohistochemistry	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	granulomas	granuloma	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	animal	animal	NN	NN	_	11	compound	_	_
11	models	model	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	bacillus	bacillus	FW	FW	_	14	compound	_	_
14	Calmette-Guerin	calmette-guerin	FW	FW	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	BCG	bcg	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	infection	infection	NN	NN	_	11	nmod	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	released	release	VBN	VBN	_	4	conj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	mononuclear	mononuclear	JJ	JJ	_	24	amod	_	_
24	phagocytes	phagocyte	NNS	NNS	_	21	nmod	_	_
25	upon	upon	IN	IN	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	24	nmod	_	_
27	by	by	IN	IN	_	29	case	_	_
28	mycobacterial	mycobacterial	JJ	JJ	_	29	amod	_	_
29	proteins	protein	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	regard	regard	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cytokine	cytokine	NN	NN	_	13	nsubj	_	_
7	interleukin	interleukin	NN	NN	_	6	dep	_	_
8	6	6	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-6	il-6	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	play	play	VB	VB	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	role	role	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	dep	_	_
18	clinical	clinical	JJ	JJ	_	19	amod	_	_
19	manifestations	manifestation	NNS	NNS	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	pathological	pathological	JJ	JJ	_	22	amod	_	_
22	events	event	NNS	NNS	_	19	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	tuberculosis	tuberculosis	NN	NN	_	25	compound	_	_
25	infection	infection	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	lipoarabinomannan	lipoarabinomannan	NN	NN	_	25	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LAM	lam	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	from	from	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	mycobacterial	mycobacterial	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	wall	wall	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	18	nsubj	_	_
16	was	be	VBD	VBD	_	18	cop	_	_
17	virtually	virtually	RB	RB	_	18	advmod	_	_
18	devoid	devoid	JJ	JJ	_	13	acl:relcl	_	_
19	of	of	IN	IN	_	20	case	_	_
20	lipopolysaccharide	lipopolysaccharide	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	LPS	lps	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	5	punct	_	_
25	stimulated	stimulate	VBD	VBD	_	3	ccomp	_	_
26	mononuclear	mononuclear	JJ	JJ	_	27	amod	_	_
27	phagocytes	phagocyte	NNS	NNS	_	25	dobj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	release	release	VB	VB	_	25	xcomp	_	_
30	IL-6	il-6	NN	NN	_	29	dobj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	dose-response	dose-response	JJ	JJ	_	34	amod	_	_
34	manner	manner	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	LAM	lam	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	LPS	lps	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	inducers	inducer	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	IL-6	il-6	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	LAM-	lam-	NN	NN	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	LPS-inducible	lps-inducible	JJ	JJ	_	7	amod	_	_
5	IL-6	il-6	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	conj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	localized	localized	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	fragment	fragment	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	positions	position	NNS	NNS	_	13	appos	_	_
16	-158	-158	CD	CD	_	18	compound	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	-49	-49	CD	CD	_	15	nummod	_	_
19	,	,	,	,	_	9	punct	_	_
20	by	by	IN	IN	_	22	case	_	_
21	deletion	deletion	NN	NN	_	22	compound	_	_
22	analysis	analysis	NN	NN	_	9	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	chloramphenicol	chloramphenicol	NN	NN	_	26	compound	_	_
25	acetyltransferase	acetyltransferase	NN	NN	_	26	compound	_	_
26	assay	assay	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	9	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	NF-IL6	nf-il6	NN	NN	_	29	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	positions	position	NNS	NNS	_	4	dep	_	_
7	-153	-153	CD	CD	_	9	compound	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	-145	-145	CD	CD	_	6	nummod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	-83	-83	CD	CD	_	13	compound	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	-75	-75	CD	CD	_	6	conj	_	_
14	)	)	-RRB-	-RRB-	_	6	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	one	one	CD	CD	_	27	nummod	_	_
17	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
18	factor	factor	NN	NN	_	27	compound	_	_
19	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
20	B	b	NN	NN	_	27	compound	_	_
21	(	(	-LRB-	-LRB-	_	27	punct	_	_
22	positions	position	NNS	NNS	_	27	compound	_	_
23	-72	-72	CD	CD	_	27	nummod	_	_
24	to	to	TO	TO	_	27	dep	_	_
25	-63	-63	CD	CD	_	27	nummod	_	_
26	)	)	-RRB-	-RRB-	_	27	punct	_	_
27	motifs	motif	NNS	NNS	_	4	conj	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	present	present	JJ	JJ	_	0	root	_	_
30	within	within	IN	IN	_	32	case	_	_
31	this	this	DT	DT	_	32	det	_	_
32	fragment	fragment	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	29	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	one	one	CD	CD	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	more	more	JJR	JJR	_	4	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	motifs	motif	NNS	NNS	_	4	nmod	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-6	il-6	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	each	each	DT	DT	_	17	nsubj	_	_
17	has	have	VBZ	VBZ	_	14	ccomp	_	_
18	positive	positive	JJ	JJ	_	20	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	18	dep	_	_
20	activity	activity	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	that	that	IN	IN	_	23	mark	_	_
23	they	they	PRP	PRP	_	17	conj	_	_
24	could	could	MD	MD	_	25	aux	_	_
25	act	act	VB	VB	_	23	dep	_	_
26	in	in	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	function-	function-	NN	NN	_	31	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	orientation-independent	orientation-independent	JJ	JJ	_	28	conj	_	_
31	manner	manner	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Deletion	deletion	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	all	all	DT	DT	_	5	det	_	_
4	three	three	CD	CD	_	5	nummod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	abolished	abolish	VBD	VBD	_	0	root	_	_
7	inducibility	inducibility	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	IL-6	il-6	NN	NN	_	11	compound	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	LAM	lam	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	LPS	lps	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	NF-IL6	nf-il6	NN	NN	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	conj	_	_
9	sites	site	NNS	NNS	_	5	dep	_	_
10	mediate	mediate	VBP	VBP	_	2	ccomp	_	_
11	IL-6	il-6	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	10	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	LPS	lps	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	LAM	lam	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	10	punct	_	_
21	acting	act	VBG	VBG	_	10	advcl	_	_
22	as	as	IN	IN	_	23	case	_	_
23	bacterial	bacterial	JJ	JJ	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	mycobacterial	mycobacterial	JJ	JJ	_	23	conj	_	_
26	response	response	NN	NN	_	27	compound	_	_
27	elements	element	NNS	NNS	_	23	dep	_	_
28	.	.	.	.	_	2	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	GM-CSF	gm-csf	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	synergy	synergy	NN	NN	_	2	nmod	_	_
10	with	with	IN	IN	_	14	case	_	_
11	either	either	CC	CC	_	14	cc:preconj	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	C	c	NN	NN	_	9	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B/AP-1	b/ap-1	NN	NN	_	14	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	cis-acting	cis-acting	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	19	nsubjpass	_	_
4	GM-kappa	gm-kappa	NN	NN	_	5	compound	_	_
5	B/GC-box	b/gc-box	NN	NN	_	3	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CLE0	cle0	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	of	of	IN	IN	_	17	case	_	_
10	the	the	DT	DT	_	17	det	_	_
11	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	17	amod	_	_
12	colony-stimulating	colony-stimulating	JJ	JJ	_	17	amod	_	_
13	factor	factor	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	GM-CSF	gm-csf	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	gene	gene	NN	NN	_	3	nmod	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	0	root	_	_
20	for	for	IN	IN	_	22	case	_	_
21	maximal	maximal	JJ	JJ	_	22	amod	_	_
22	induction	induction	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	Jurkat	jurkat	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	costimulation	costimulation	NN	NN	_	22	nmod	_	_
29	with	with	IN	IN	_	31	case	_	_
30	phorbol-12-myristate	phorbol-12-myristate	NN	NN	_	31	compound	_	_
31	acetate	acetate	NN	NN	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	PMA	pma	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	Ca2+	ca2+	NN	NN	_	37	compound	_	_
37	ionophore	ionophore	NN	NN	_	31	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	A23187	a23187	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GM-kappa	gm-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	recognized	recognize	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	mainly	mainly	RB	RB	_	14	advmod	_	_
14	induced	induce	VBN	VBN	_	9	acl:relcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PMA	pma	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CLE0	cle0	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	4	nsubj	_	_
4	interacts	interact	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	factors	factor	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	related	related	JJ	JJ	_	6	amod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	PMA-induced	pma-induced	JJ	JJ	_	12	amod	_	_
12	AP-1	ap-1	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	PMA/A23187-induced	pma/a23187-induced	JJ	JJ	_	16	amod	_	_
16	NF-AT	nf-at	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	11	mark	_	_
4	signal	signal	NN	NN	_	6	compound	_	_
5	transducing	transducing	NN	NN	_	6	compound	_	_
6	components	component	NNS	NNS	_	11	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	activate	activate	VB	VB	_	2	ccomp	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	GM-CSF	gm-csf	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	30	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	p50/p65	p50/p65	NN	NN	_	1	nmod	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	-	-	:	:	_	6	punct	_	_
9	or	or	CC	CC	_	6	cc	_	_
10	AP-1	ap-1	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	c-Jun/c-Fos	c-jun/c-fos	NN	NN	_	6	conj	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-	-	:	:	_	12	punct	_	_
15	expression	expression	NN	NN	_	16	compound	_	_
16	vectors	vector	NNS	NNS	_	6	dep	_	_
17	into	into	IN	IN	_	19	case	_	_
18	Jurkat	jurkat	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	1	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	luciferase	luciferase	NN	NN	_	23	compound	_	_
23	reporter	reporter	NN	NN	_	19	nmod	_	_
24	containing	contain	VBG	VBG	_	23	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	GM-CSF	gm-csf	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	24	dobj	_	_
28	did	do	VBD	VBD	_	30	aux	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	stimulate	stimulate	VB	VB	_	0	root	_	_
31	transcription	transcription	NN	NN	_	30	dobj	_	_
32	from	from	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	GM-CSF	gm-csf	NN	NN	_	35	compound	_	_
35	promoter	promoter	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	30	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	cotransfection	cotransfection	NN	NN	_	14	nsubj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	combination	combination	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	AP-1	ap-1	NN	NN	_	10	conj	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	augmented	augment	VBD	VBD	_	0	root	_	_
15	transcription	transcription	NN	NN	_	14	dobj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	GM-CSF	gm-csf	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	GM-kappa	gm-kappa	NN	NN	_	23	compound	_	_
23	B/GC-box	b/gc-box	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	CLE0	cle0	NN	NN	_	23	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	AP-1/NF-AT	ap-1/nf-at	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	14	punct	_	_

1	Expression	expression	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	constitutively	constitutively	RB	RB	_	5	advmod	_	_
5	active	active	JJ	JJ	_	6	amod	_	_
6	calcineurin	calcineurin	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CN	cn	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	a	a	DT	DT	_	14	det	_	_
12	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	phosphatase	phosphatase	NN	NN	_	6	appos	_	_
15	,	,	,	,	_	1	punct	_	_
16	potentiated	potentiate	VBD	VBD	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	fold	fold	NN	NN	_	16	nmod	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	16	dobj	_	_
23	by	by	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B/AP-1	b/ap-1	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	constitutively	constitutively	RB	RB	_	3	advmod	_	_
3	active	active	JJ	JJ	_	4	amod	_	_
4	forms	form	NNS	NNS	_	15	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CN	cn	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	4	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PKC	pkc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	synergistically	synergistically	RB	RB	_	15	advmod	_	_
15	activated	activate	VBD	VBD	_	0	root	_	_
16	transcription	transcription	NN	NN	_	15	dobj	_	_
17	from	from	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	GM-CSF	gm-csf	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	cooperation	cooperation	NN	NN	_	15	nsubjpass	_	_
6	among	among	IN	IN	_	8	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B-	b-	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	AP-1-	ap-1-	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	NF-AT-binding	nf-at-binding	JJ	JJ	_	8	conj	_	_
13	sequences	sequence	NNS	NNS	_	8	dep	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	3	ccomp	_	_
16	for	for	IN	IN	_	17	case	_	_
17	induction	induction	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	GM-CSF	gm-csf	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	through	through	IN	IN	_	23	case	_	_
23	PKC-	pkc-	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Ca2+-	ca2+-	NN	NN	_	23	conj	_	_
26	signaling	signaling	JJ	JJ	_	27	amod	_	_
27	pathways	pathway	NNS	NNS	_	23	dep	_	_
28	downstream	downstream	RB	RB	_	23	advmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF(P)	nf(p)	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	3	appos	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	interacts	interact	VBZ	VBZ	_	7	acl:relcl	_	_
10	with	with	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
13	P	p	NN	NN	_	14	compound	_	_
14	sequence	sequence	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	5'-CGAAAATTTCC-3'	5'-cgaaaatttcc-3'	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	interleukin-4	interleukin-4	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	14	nmod	_	_
23	:	:	:	:	_	1	punct	_	_
24	relationship	relationship	NN	NN	_	1	dep	_	_
25	to	to	TO	TO	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	NF-AT	nf-at	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	P	p	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	35	nsubj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	interleukin-4	interleukin-4	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	IL-4	il-4	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	defined	define	VBN	VBN	_	11	acl:relcl	_	_
16	as	as	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	responsive	responsive	JJ	JJ	_	19	amod	_	_
19	element	element	NN	NN	_	15	nmod	_	_
20	for	for	IN	IN	_	23	case	_	_
21	phorbol	phorbol	NN	NN	_	23	compound	_	_
22	12-myristate	12-myristate	NN	NN	_	23	compound	_	_
23	13-acetate	13-acetate	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	calcium	calcium	NN	NN	_	26	compound	_	_
26	ionophore	ionophore	NN	NN	_	23	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	A23187	a23187	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	in	in	IN	IN	_	33	case	_	_
31	Jurkat	jurkat	NN	NN	_	33	compound	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	23	nmod	_	_
34	,	,	,	,	_	3	punct	_	_
35	shares	share	VBZ	VBZ	_	0	root	_	_
36	sequence	sequence	NN	NN	_	37	compound	_	_
37	similarity	similarity	NN	NN	_	35	dobj	_	_
38	with	with	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	NF-kappa	nf-kappa	NN	NN	_	41	compound	_	_
41	B	b	NN	NN	_	35	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	the	the	DT	DT	_	46	det	_	_
44	NF-AT	nf-at	NN	NN	_	46	compound	_	_
45	binding	binding	NN	NN	_	46	compound	_	_
46	sites	site	NNS	NNS	_	41	conj	_	_
47	.	.	.	.	_	35	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	16	mark	_	_
4	NF(P)	nf(p)	NN	NN	_	16	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	4	appos	_	_
9	specific	specific	JJ	JJ	_	8	amod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	P	p	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	related	related	JJ	JJ	_	2	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-AT	nf-at	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	P65	p65	NN	NN	_	2	dep	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	P65/P50	p65/p50	NN	NN	_	7	compound	_	_
7	heterodimer	heterodimer	NN	NN	_	4	conj	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	bound	bind	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	P	p	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	electrophoretic	electrophoretic	JJ	JJ	_	18	amod	_	_
16	mobility	mobility	NN	NN	_	18	compound	_	_
17	shift	shift	NN	NN	_	18	compound	_	_
18	assays	assay	NNS	NNS	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	EMSA	emsa	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	activated	activate	VBD	VBD	_	9	conj	_	_
24	transcription	transcription	NN	NN	_	23	dobj	_	_
25	through	through	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	P	p	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	24	nmod	_	_
29	when	when	WRB	WRB	_	33	advmod	_	_
30	expression	expression	NN	NN	_	31	compound	_	_
31	plasmids	plasmid	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	cotransfected	cotransfect	VBN	VBN	_	23	advcl	_	_
34	with	with	IN	IN	_	38	case	_	_
35	P	p	NN	NN	_	38	compound	_	_
36	sequence-driven	sequence-driven	JJ	JJ	_	38	amod	_	_
37	reporter	reporter	NN	NN	_	38	compound	_	_
38	plasmids	plasmid	NNS	NNS	_	33	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	Jurkat	jurkat	NN	NN	_	42	compound	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	EMSAs	emsa	NNS	NNS	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	NF(P)	nf(p)	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	unlabeled	unlabeled	JJ	JJ	_	13	amod	_	_
11	NF-AT	nf-at	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	7	nmod	_	_
14	but	but	CC	CC	_	13	cc	_	_
15	not	not	RB	RB	_	21	neg	_	_
16	by	by	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	unlabeled	unlabeled	JJ	JJ	_	21	amod	_	_
19	AP1	ap1	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	13	conj	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	purified	purify	VBN	VBN	_	24	amod	_	_
24	NF-AT	nf-at	NN	NN	_	25	nsubj	_	_
25	contained	contain	VBD	VBD	_	7	conj	_	_
26	an	a	DT	DT	_	27	det	_	_
27	activity	activity	NN	NN	_	25	dobj	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	bound	bind	VBD	VBD	_	27	acl:relcl	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	P	p	NN	NN	_	33	compound	_	_
33	sequence	sequence	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	mobility	mobility	NN	NN	_	3	compound	_	_
3	shift	shift	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	sequence	sequence	NN	NN	_	6	compound	_	_
6	specificity	specificity	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-AT	nf-at	NN	NN	_	3	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	similar	similar	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	those	those	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF(P)	nf(p)	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	only	only	RB	RB	_	19	advmod	_	_
17	a	a	DT	DT	_	19	det	_	_
18	small	small	JJ	JJ	_	19	amod	_	_
19	amount	amount	NN	NN	_	23	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	P65	p65	NN	NN	_	19	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	detected	detect	VBN	VBN	_	10	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	NF(P)	nf(p)	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	crude	crude	JJ	JJ	_	29	amod	_	_
28	nuclear	nuclear	JJ	JJ	_	27	dep	_	_
29	extracts	extract	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	component	component	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	12	nsubj	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-AT	nf-at	NN	NN	_	8	nmod	_	_
12	has	have	VBZ	VBZ	_	3	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	potential	potential	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	reconstitute	reconstitute	VB	VB	_	14	acl	_	_
17	NF(P)	nf(p)	NN	NN	_	16	dobj	_	_
18	whereas	whereas	IN	IN	_	24	mark	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	24	nsubj	_	_
21	alone	alone	RB	RB	_	20	advmod	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	account	account	VB	VB	_	12	advcl	_	_
25	for	for	IN	IN	_	26	case	_	_
26	NF(P)	nf(p)	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	crude	crude	JJ	JJ	_	29	amod	_	_
29	extracts	extract	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	NF-AT	nf-at	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	NF(P)	nf(p)	NN	NN	_	7	nsubj	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	contain	contain	VB	VB	_	0	root	_	_
8	AP1	ap1	NN	NN	_	7	dobj	_	_
9	as	as	IN	IN	_	13	case	_	_
10	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	component	component	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Hypoxia	hypoxia	NN	NN	_	2	nsubj	_	_
2	causes	cause	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	through	through	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	tyrosine	tyrosine	NN	NN	_	20	compound	_	_
20	residues	residue	NNS	NNS	_	12	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	response	response	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	mammalian	mammalian	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	stress	stress	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	9	nmod	_	_
14	such	such	JJ	JJ	_	19	case	_	_
15	as	as	IN	IN	_	14	mwe	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	induce	induce	VB	VB	_	19	acl	_	_
26	a	a	DT	DT	_	28	det	_	_
27	wide	wide	JJ	JJ	_	28	amod	_	_
28	variety	variety	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	early	early	JJ	JJ	_	32	amod	_	_
31	response	response	NN	NN	_	32	compound	_	_
32	genes	gene	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	exposure	exposure	NN	NN	_	18	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	cells	cell	NNS	NNS	_	8	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	hypoxia	hypoxia	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	0.02	0.02	CD	CD	_	15	compound	_	_
15	%	%	NN	NN	_	16	amod	_	_
16	O2	o2	CD	CD	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	results	result	VBZ	VBZ	_	6	ccomp	_	_
19	in	in	IN	IN	_	24	case	_	_
20	I	i	NN	NN	_	24	compound	_	_
21	kappa	kappa	NN	NN	_	24	compound	_	_
22	B	b	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	degradation	degradation	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	increased	increase	VBN	VBN	_	31	amod	_	_
27	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
28	B	b	NN	NN	_	31	compound	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	24	conj	_	_
32	,	,	,	,	_	24	punct	_	_
33	and	and	CC	CC	_	24	cc	_	_
34	transactivation	transactivation	NN	NN	_	24	conj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	a	a	DT	DT	_	39	det	_	_
37	reporter	reporter	NN	NN	_	39	compound	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	construct	construct	NN	NN	_	34	nmod	_	_
40	containing	contain	VBG	VBG	_	39	acl	_	_
41	two	two	CD	CD	_	46	nummod	_	_
42	NF-kappa	nf-kappa	NN	NN	_	46	compound	_	_
43	B	b	NN	NN	_	46	compound	_	_
44	DNA	dna	NN	NN	_	46	compound	_	_
45	binding	binding	NN	NN	_	46	compound	_	_
46	sites	site	NNS	NNS	_	40	dobj	_	_
47	.	.	.	.	_	6	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	8	case	_	_
5	protein	protein	NN	NN	_	8	compound	_	_
6	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	13	det	_	_
11	dominant	dominant	JJ	JJ	_	13	amod	_	_
12	negative	negative	JJ	JJ	_	13	amod	_	_
13	allele	allele	NN	NN	_	8	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	c-Raf-1	c-raf-1	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Raf	raf	NN	NN	_	15	appos	_	_
18	301	301	CD	CD	_	17	nummod	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	I	i	NN	NN	_	25	compound	_	_
22	kappa	kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	alpha	alpha	NN	NN	_	25	compound	_	_
25	degradation	degradation	NN	NN	_	20	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	transactivation	transactivation	NN	NN	_	25	conj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	kappa	kappa	NN	NN	_	37	compound	_	_
35	B	b	NN	NN	_	37	compound	_	_
36	reporter	reporter	NN	NN	_	37	compound	_	_
37	constructs	construct	NNS	NNS	_	32	nmod	_	_
38	by	by	IN	IN	_	39	case	_	_
39	hypoxia	hypoxia	NN	NN	_	25	nmod	_	_
40	.	.	.	.	_	20	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	demonstrate	demonstrate	VB	VB	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	link	link	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	changes	change	NNS	NNS	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	phosphorylation	phosphorylation	NN	NN	_	11	compound	_	_
11	pattern	pattern	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	11	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	2	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	immunoprecipitated	immunoprecipitate	VBD	VBD	_	2	parataxis	_	_
24	I	i	NN	NN	_	27	compound	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	23	dobj	_	_
28	after	after	IN	IN	_	30	case	_	_
29	varying	vary	VBG	VBG	_	30	amod	_	_
30	times	time	NNS	NNS	_	23	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	hypoxic	hypoxic	JJ	JJ	_	33	amod	_	_
33	exposure	exposure	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	23	cc	_	_
35	found	find	VBD	VBD	_	23	conj	_	_
36	that	that	IN	IN	_	41	mark	_	_
37	its	its	PRP$	PRP$	_	40	nmod:poss	_	_
38	tyrosine	tyrosine	NN	NN	_	40	compound	_	_
39	phosphorylation	phosphorylation	NN	NN	_	40	compound	_	_
40	status	status	NN	NN	_	41	nsubj	_	_
41	increased	increase	VBD	VBD	_	35	ccomp	_	_
42	during	during	IN	IN	_	44	case	_	_
43	hypoxic	hypoxic	JJ	JJ	_	44	amod	_	_
44	exposure	exposure	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	transfer	transfer	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
7	phosphoryl	phosphoryl	NN	NN	_	8	compound	_	_
8	groups	group	NNS	NNS	_	4	nmod	_	_
9	onto	onto	IN	IN	_	13	case	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	4	nmod	_	_
14	prevented	prevent	VBD	VBD	_	0	root	_	_
15	I	i	NN	NN	_	19	compound	_	_
16	kappa	kappa	NN	NN	_	19	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	degradation	degradation	NN	NN	_	14	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	19	conj	_	_
24	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	22	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	activators	activator	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	nmod	_	_
9	such	such	JJ	JJ	_	13	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	phorbol	phorbol	NN	NN	_	13	compound	_	_
12	myristate	myristate	NN	NN	_	13	compound	_	_
13	acetate	acetate	NN	NN	_	5	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	necrosis	necrosis	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	22	punct	_	_
19	we	we	PRP	PRP	_	22	nsubj	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	detect	detect	VB	VB	_	0	root	_	_
23	changes	change	NNS	NNS	_	22	dobj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	tyrosine	tyrosine	NN	NN	_	28	compound	_	_
27	phosphorylation	phosphorylation	NN	NN	_	28	compound	_	_
28	status	status	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	I	i	NN	NN	_	33	compound	_	_
31	kappa	kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	28	nmod	_	_
34	following	follow	VBG	VBG	_	35	case	_	_
35	treatment	treatment	NN	NN	_	23	nmod	_	_
36	with	with	IN	IN	_	37	case	_	_
37	either	either	DT	DT	_	35	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	these	these	DT	DT	_	40	det	_	_
40	agents	agent	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	I	i	NN	NN	_	11	compound	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	6	nmod	_	_
12	during	during	IN	IN	_	13	case	_	_
13	hypoxia	hypoxia	NN	NN	_	6	nmod	_	_
14	is	be	VBZ	VBZ	_	18	cop	_	_
15	an	a	DT	DT	_	18	det	_	_
16	important	important	JJ	JJ	_	18	amod	_	_
17	proximal	proximal	JJ	JJ	_	16	dep	_	_
18	step	step	NN	NN	_	3	ccomp	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	precedes	precede	VBZ	VBZ	_	18	acl:relcl	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	dissociation	dissociation	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	degradation	degradation	NN	NN	_	22	conj	_	_
25	from	from	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid-induced	acid-induced	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	CD38	cd38	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	0	root	_	_
12	through	through	IN	IN	_	15	case	_	_
13	retinoic	retinoic	JJ	JJ	_	15	amod	_	_
14	acid	acid	NN	NN	_	15	compound	_	_
15	receptor-alpha	receptor-alpha	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	CD38	cd38	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	leukocyte	leukocyte	NN	NN	_	6	compound	_	_
5	differentiation	differentiation	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	10	nsubjpass	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	thought	think	VBN	VBN	_	6	acl:relcl	_	_
11	to	to	TO	TO	_	15	mark	_	_
12	be	be	VB	VB	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	phenotypic	phenotypic	JJ	JJ	_	15	amod	_	_
15	marker	marker	NN	NN	_	10	xcomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	different	different	JJ	JJ	_	18	amod	_	_
18	subpopulations	subpopulation	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	T-	t-	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	B-lymphocytes	b-lymphocyte	NNS	NNS	_	20	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	myeloid	myeloid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	CD38	cd38	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	during	during	IN	IN	_	10	case	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	stages	stage	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	differentiation	differentiation	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Virtually	virtually	RB	RB	_	3	advmod	_	_
2	no	no	DT	DT	_	3	neg	_	_
3	information	information	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	available	available	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	regulation	regulation	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	functions	function	NNS	NNS	_	7	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD38	cd38	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Recently	recently	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	all-trans-retinoic	all-trans-retinoic	JJ	JJ	_	6	amod	_	_
6	acid	acid	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	ATRA	atra	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	16	cop	_	_
11	a	a	DT	DT	_	16	det	_	_
12	potent	potent	JJ	JJ	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	highly	highly	RB	RB	_	15	advmod	_	_
15	specific	specific	JJ	JJ	_	12	conj	_	_
16	inducer	inducer	NN	NN	_	3	ccomp	_	_
17	of	of	IN	IN	_	19	case	_	_
18	CD38	cd38	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	promyelocytic	promyelocytic	JJ	JJ	_	24	amod	_	_
23	leukemia	leukemia	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	ATRA-induced	atra-induced	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CD38	cd38	NN	NN	_	9	compound	_	_
9	antigen	antigen	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
15	through	through	IN	IN	_	18	case	_	_
16	retinoic	retinoic	JJ	JJ	_	18	amod	_	_
17	acid-alpha	acid-alpha	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	RAR	rar	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	ATRA	atra	NN	NN	_	2	nsubj	_	_
2	failed	fail	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	induce	induce	VB	VB	_	2	xcomp	_	_
5	CD38	cd38	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	mutant	mutant	JJ	JJ	_	10	amod	_	_
10	subclone	subclone	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	HL-60	hl-60	NN	NN	_	17	compound	_	_
14	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
15	leukemia	leukemia	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	designated	designate	VBN	VBN	_	17	dep	_	_
20	HL-60R	hl-60r	NN	NN	_	19	xcomp	_	_
21	)	)	-RRB-	-RRB-	_	19	punct	_	_
22	that	that	WDT	WDT	_	25	nsubj	_	_
23	is	be	VBZ	VBZ	_	25	cop	_	_
24	relatively	relatively	RB	RB	_	25	advmod	_	_
25	resistant	resistant	JJ	JJ	_	17	acl:relcl	_	_
26	to	to	TO	TO	_	29	case	_	_
27	ATRA-induced	atra-induced	JJ	JJ	_	29	amod	_	_
28	granulocytic	granulocytic	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Retroviral	retroviral	JJ	JJ	_	3	amod	_	_
2	vector-mediated	vector-mediated	JJ	JJ	_	3	amod	_	_
3	transduction	transduction	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	RA	ra	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	RAR	rar	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	into	into	IN	IN	_	14	case	_	_
12	this	this	DT	DT	_	14	det	_	_
13	HL-60R	hl-60r	NN	NN	_	14	compound	_	_
14	subclone	subclone	NN	NN	_	3	nmod	_	_
15	completely	completely	RB	RB	_	16	advmod	_	_
16	restored	restore	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	sensitivity	sensitivity	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	ATRA	atra	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	terms	term	NNS	NNS	_	16	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
28	ability	ability	NN	NN	_	25	nmod	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	express	express	VB	VB	_	28	acl	_	_
31	CD38	cd38	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	CD38	cd38	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	inducible	inducible	JJ	JJ	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	ATRA	atra	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HL-60R	hl-60r	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	transfected	transfect	VBN	VBN	_	13	acl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	functional	functional	JJ	JJ	_	20	amod	_	_
19	RAR	rar	NN	NN	_	20	compound	_	_
20	beta	beta	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	RAR	rar	NN	NN	_	23	compound	_	_
23	gamma	gamma	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	or	or	CC	CC	_	20	cc	_	_
26	RXR	rxr	NN	NN	_	28	compound	_	_
27	alpha	alpha	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	20	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	Induction	induction	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD38	cd38	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	acute	acute	JJ	JJ	_	6	amod	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	acute	acute	JJ	JJ	_	9	amod	_	_
9	myeloblastic	myeloblastic	JJ	JJ	_	6	conj	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	dep	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	independent	independent	JJ	JJ	_	0	root	_	_
14	of	of	IN	IN	_	16	case	_	_
15	ATRA-induced	atra-induced	JJ	JJ	_	16	amod	_	_
16	cytodifferentiation	cytodifferentiation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Following	follow	VBG	VBG	_	2	case	_	_
2	culture	culture	NN	NN	_	12	nmod	_	_
3	with	with	IN	IN	_	4	case	_	_
4	ATRA	atra	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	increased	increase	VBN	VBN	_	9	amod	_	_
7	CD38	cd38	NN	NN	_	9	compound	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	12	nsubjpass	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	18	case	_	_
14	normal	normal	JJ	JJ	_	18	amod	_	_
15	CD34+	cd34+	JJ	JJ	_	18	amod	_	_
16	bone	bone	NN	NN	_	18	compound	_	_
17	marrow	marrow	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	but	but	CC	CC	_	18	cc	_	_
21	not	not	RB	RB	_	25	neg	_	_
22	on	on	IN	IN	_	25	case	_	_
23	normal	normal	JJ	JJ	_	25	amod	_	_
24	circulating	circulate	VBG	VBG	_	25	amod	_	_
25	granulocytes	granulocyte	NNS	NNS	_	18	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	conclude	conclude	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	CD38	cd38	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	ATRA	atra	NN	NN	_	11	nmod:npmod	_	_
11	inducible	inducible	JJ	JJ	_	6	ccomp	_	_
12	in	in	IN	IN	_	15	case	_	_
13	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
14	leukemia	leukemia	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	normal	normal	JJ	JJ	_	21	amod	_	_
18	CD34+	cd34+	JJ	JJ	_	21	amod	_	_
19	bone	bone	NN	NN	_	21	compound	_	_
20	marrow	marrow	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	independent	independent	JJ	JJ	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	differentiation	differentiation	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	4	conj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	RAR	rar	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	HL-60	hl-60	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
18	a	a	DT	DT	_	20	det	_	_
19	similar	similar	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	23	case	_	_
22	RAR	rar	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	CD38	cd38	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	20	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	other	other	JJ	JJ	_	30	amod	_	_
29	hematopoietic	hematopoietic	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	associated	associate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	nuclease-hypersensitive	nuclease-hypersensitive	JJ	JJ	_	10	amod	_	_
10	site	site	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	pol	pol	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	immunodeficiency	immunodeficiency	NN	NN	_	19	compound	_	_
18	virus	virus	NN	NN	_	19	compound	_	_
19	type	type	NN	NN	_	14	nmod	_	_
20	1	1	CD	CD	_	19	nummod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Analysis	analysis	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	chromatin	chromatin	NN	NN	_	5	compound	_	_
5	organization	organization	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	17	case	_	_
7	the	the	DT	DT	_	17	det	_	_
8	integrated	integrate	VBN	VBN	_	17	amod	_	_
9	human	human	JJ	JJ	_	17	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
11	virus	virus	NN	NN	_	17	compound	_	_
12	type	type	NN	NN	_	17	compound	_	_
13	1	1	CD	CD	_	17	nummod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	genome	genome	NN	NN	_	5	nmod	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	previously	previously	RB	RB	_	20	advmod	_	_
20	revealed	reveal	VBN	VBN	_	0	root	_	_
21	a	a	DT	DT	_	26	det	_	_
22	major	major	JJ	JJ	_	26	amod	_	_
23	constitutive	constitutive	JJ	JJ	_	26	amod	_	_
24	DNase	dnase	NN	NN	_	26	compound	_	_
25	I-hypersensitive	i-hypersensitive	JJ	JJ	_	26	amod	_	_
26	site	site	NN	NN	_	20	dobj	_	_
27	associated	associate	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	pol	pol	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	E	E	NNP	NNP	_	35	compound	_	_
34	.	.	.	.	_	35	punct	_	_
35	Verdin	Verdin	NNP	NNP	_	20	dep	_	_
36	,	,	,	,	_	35	punct	_	_
37	J	J	NNP	NNP	_	39	compound	_	_
38	.	.	.	.	_	39	punct	_	_
39	Virol	Virol	NNP	NNP	_	35	appos	_	_
40	.	.	.	.	_	39	punct	_	_
41	65	65	CD	CD	_	39	nummod	_	_
42	:	:	:	:	_	35	punct	_	_
43	6790-6799	6790-6799	CD	CD	_	35	dep	_	_
44	,	,	,	,	_	35	punct	_	_
45	1991	1991	CD	CD	_	35	amod	_	_
46	)	)	-RRB-	-RRB-	_	35	punct	_	_
47	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	high-resolution	high-resolution	JJ	JJ	_	7	amod	_	_
7	mapping	mapping	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	site	site	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	DNase	dnase	NN	NN	_	7	nmod	_	_
13	I	i	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	micrococcal	micrococcal	JJ	JJ	_	16	amod	_	_
16	nuclease	nuclease	NN	NN	_	12	conj	_	_
17	identified	identify	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	nucleosome-free	nucleosome-free	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	17	dobj	_	_
21	centered	center	VBN	VBN	_	20	acl	_	_
22	around	around	IN	IN	_	25	case	_	_
23	nucleotides	nucleotide	NNS	NNS	_	25	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	nt	nt	NNS	NNS	_	21	nmod	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	4490	4490	CD	CD	_	25	nummod	_	_
28	to	to	TO	TO	_	25	dep	_	_
29	4766	4766	CD	CD	_	25	nummod	_	_
30	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	500-bp	500-bp	JJ	JJ	_	3	amod	_	_
3	fragment	fragment	NN	NN	_	14	nsubj	_	_
4	encompassing	encompass	VBG	VBG	_	3	acl	_	_
5	this	this	DT	DT	_	7	det	_	_
6	hypersensitive	hypersensitive	JJ	JJ	_	7	amod	_	_
7	site	site	NN	NN	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	nt	nt	NNS	NNS	_	7	appos	_	_
10	4481	4481	CD	CD	_	9	nummod	_	_
11	to	to	TO	TO	_	9	dep	_	_
12	4982	4982	CD	CD	_	9	nummod	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	exhibited	exhibit	VBD	VBD	_	0	root	_	_
15	transcription-enhancing	transcription-enhancing	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	two-	two-	CD	CD	_	20	nummod	_	_
19	to	to	TO	TO	_	20	dep	_	_
20	threefold	threefold	JJ	JJ	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	when	when	WRB	WRB	_	25	advmod	_	_
23	it	it	PRP	PRP	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	cloned	clone	VBN	VBN	_	14	advcl	_	_
26	in	in	IN	IN	_	29	case	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	natural	natural	JJ	JJ	_	29	amod	_	_
29	position	position	NN	NN	_	25	nmod	_	_
30	with	with	IN	IN	_	31	case	_	_
31	respect	respect	NN	NN	_	25	nmod	_	_
32	to	to	TO	TO	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	HIV-1	hiv-1	NN	NN	_	35	compound	_	_
35	promoter	promoter	NN	NN	_	31	nmod	_	_
36	after	after	IN	IN	_	38	case	_	_
37	transient	transient	JJ	JJ	_	38	amod	_	_
38	transfection	transfection	NN	NN	_	25	nmod	_	_
39	in	in	IN	IN	_	40	case	_	_
40	U937	u937	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	CEM	cem	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	40	conj	_	_
44	.	.	.	.	_	14	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	footprinting	footprinting	NN	NN	_	1	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	gel	gel	NN	NN	_	8	compound	_	_
7	shift	shift	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	4	conj	_	_
9	,	,	,	,	_	1	punct	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	identified	identify	VBN	VBN	_	1	parataxis	_	_
13	four	four	CD	CD	_	16	nummod	_	_
14	distinct	distinct	JJ	JJ	_	16	amod	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	sites	site	NNS	NNS	_	12	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	within	within	IN	IN	_	24	case	_	_
21	this	this	DT	DT	_	24	det	_	_
22	positive	positive	JJ	JJ	_	24	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	element	element	NN	NN	_	12	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Site	site	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	nt	nt	NNS	NNS	_	2	appos	_	_
5	4519	4519	CD	CD	_	4	nummod	_	_
6	to	to	TO	TO	_	4	dep	_	_
7	4545	4545	CD	CD	_	4	nummod	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	bound	bind	VBD	VBD	_	0	root	_	_
11	four	four	CD	CD	_	15	nummod	_	_
12	distinct	distinct	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	complexes	complex	NNS	NNS	_	10	dobj	_	_
16	:	:	:	:	_	10	punct	_	_
17	a	a	DT	DT	_	19	det	_	_
18	ubiquitous	ubiquitous	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	10	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	a	a	DT	DT	_	23	det	_	_
22	T-cell-specific	t-cell-specific	JJ	JJ	_	23	amod	_	_
23	factor	factor	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	a	a	DT	DT	_	27	det	_	_
26	B-cell-specific	b-cell-specific	JJ	JJ	_	27	amod	_	_
27	factor	factor	NN	NN	_	19	conj	_	_
28	,	,	,	,	_	19	punct	_	_
29	and	and	CC	CC	_	19	cc	_	_
30	the	the	DT	DT	_	31	det	_	_
31	monocyte/macrophage-	monocyte/macrophage-	NN	NN	_	19	conj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	B-cell-specific	b-cell-specific	JJ	JJ	_	35	amod	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	factor	factor	NN	NN	_	31	conj	_	_
36	PU.1/Spi-1	pu.1/spi-1	NN	NN	_	31	dep	_	_
37	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	most	most	JJS	JJS	_	4	amod	_	_
3	HIV-1	hiv-1	NN	NN	_	4	compound	_	_
4	isolates	isolate	NNS	NNS	_	16	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	12	nmod	_	_
7	this	this	DT	DT	_	9	det	_	_
8	PU	pu	NN	NN	_	9	compound	_	_
9	box	box	NN	NN	_	12	nsubjpass	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	conserved	conserve	VBN	VBN	_	4	acl:relcl	_	_
13	,	,	,	,	_	16	punct	_	_
14	it	it	PRP	PRP	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	replaced	replace	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	binding	bind	VBG	VBG	_	20	amod	_	_
20	site	site	NN	NN	_	16	nmod	_	_
21	for	for	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	related	related	JJ	JJ	_	25	amod	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	Ets1	ets1	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	Factors	factor	NNS	NNS	_	12	nsubj	_	_
2	binding	bind	VBG	VBG	_	1	acl	_	_
3	to	to	TO	TO	_	5	case	_	_
4	site	site	NN	NN	_	5	compound	_	_
5	C	c	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	nt	nt	NNS	NNS	_	5	appos	_	_
8	4681	4681	CD	CD	_	7	nummod	_	_
9	to	to	TO	TO	_	7	dep	_	_
10	4701	4701	CD	CD	_	7	nummod	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	had	have	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	specificity	specificity	NN	NN	_	12	dobj	_	_
16	similar	similar	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	factors	factor	NNS	NNS	_	18	nmod	_	_
21	binding	bind	VBG	VBG	_	20	acl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	site	site	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	except	except	IN	IN	_	28	case	_	_
27	for	for	IN	IN	_	28	case	_	_
28	PU.1/Spi-1	pu.1/spi-1	NN	NN	_	12	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	GC	gc	NN	NN	_	3	compound	_	_
3	box	box	NN	NN	_	11	nsubjpass	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	a	a	DT	DT	_	7	det	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	site	site	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	Sp1	sp1	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	nt	nt	NNS	NNS	_	11	dep	_	_
14	4623	4623	CD	CD	_	13	nummod	_	_
15	to	to	TO	TO	_	13	dep	_	_
16	4631	4631	CD	CD	_	13	nummod	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	.	.	.	.	_	11	punct	_	_

1	Site	site	NN	NN	_	2	compound	_	_
2	D	d	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	nt	nt	NNS	NNS	_	2	appos	_	_
5	4816	4816	CD	CD	_	4	nummod	_	_
6	to	to	TO	TO	_	4	dep	_	_
7	4851	4851	CD	CD	_	4	nummod	_	_
8	)	)	-RRB-	-RRB-	_	4	punct	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	bound	bind	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	ubiquitously	ubiquitously	RB	RB	_	14	advmod	_	_
13	expressed	express	VBN	VBN	_	14	amod	_	_
14	factor	factor	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	3	dobj	_	_
8	associated	associate	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	nuclease-hypersensitive	nuclease-hypersensitive	JJ	JJ	_	12	amod	_	_
12	site	site	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	pol	pol	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HIV-1	hiv-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	activity	activity	NN	NN	_	26	nsubjpass	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	controlled	control	VBN	VBN	_	20	ccomp	_	_
27	by	by	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	complex	complex	JJ	JJ	_	30	amod	_	_
30	interplay	interplay	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	cis-regulatory	cis-regulatory	JJ	JJ	_	33	amod	_	_
33	elements	element	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Androgen	androgen	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	leukocytes	leukocyte	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	healthy	healthy	JJ	JJ	_	11	amod	_	_
11	males	male	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	females	female	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Androgen	androgen	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	circulating	circulate	VBG	VBG	_	11	amod	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	donors	donor	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	both	both	DT	DT	_	17	det	_	_
17	sexes	sex	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Cells	cell	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	separated	separate	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	6	case	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	samples	sample	NNS	NNS	_	3	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	Ficoll	ficoll	NN	NN	_	10	compound	_	_
10	gradient	gradient	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	incubated	incubate	VBN	VBN	_	3	conj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	concentrations	concentration	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	-LSB-3H-RSB-testosterone	-lsb-3h-rsb-testosterone	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	presence	presence	NN	NN	_	12	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	absence	absence	NN	NN	_	20	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	400-fold	400-fold	JJ	JJ	_	26	amod	_	_
26	excess	excess	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	unlabelled	unlabelled	JJ	JJ	_	29	amod	_	_
29	testosterone	testosterone	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	data	datum	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	derived	derive	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	Scatchard	scatchard	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	sites	site	NNS	NNS	_	4	nsubj	_	_
4	fulfil	fulfil	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	required	required	JJ	JJ	_	7	amod	_	_
7	criteria	criterion	NNS	NNS	_	4	dobj	_	_
8	for	for	IN	IN	_	12	case	_	_
9	specific	specific	JJ	JJ	_	12	amod	_	_
10	steroid	steroid	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	7	nmod	_	_
13	however	however	RB	RB	_	4	advmod	_	_
14	differ	differ	VBP	VBP	_	4	dep	_	_
15	somewhat	somewhat	RB	RB	_	14	advmod	_	_
16	from	from	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	classic	classic	JJ	JJ	_	20	amod	_	_
19	androgen	androgen	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	14	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	genital	genital	JJ	JJ	_	24	amod	_	_
23	skin	skin	NN	NN	_	24	compound	_	_
24	fibroblast	fibroblast	NN	NN	_	20	nmod	_	_
25	:	:	:	:	_	4	punct	_	_
26	in	in	IN	IN	_	29	case	_	_
27	fertile	fertile	JJ	JJ	_	29	amod	_	_
28	adult	adult	JJ	JJ	_	27	dep	_	_
29	males	male	NNS	NNS	_	38	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	n	n	NN	NN	_	29	dep	_	_
32	=	=	JJ	JJ	_	31	amod	_	_
33	20	20	CD	CD	_	32	dep	_	_
34	)	)	-RRB-	-RRB-	_	31	punct	_	_
35	the	the	DT	DT	_	37	det	_	_
36	binding	bind	VBG	VBG	_	37	amod	_	_
37	sites	site	NNS	NNS	_	38	nsubj	_	_
38	showed	show	VBD	VBD	_	4	parataxis	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	1	1	LS	LS	_	44	dep	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	a	a	DT	DT	_	44	det	_	_
43	high	high	JJ	JJ	_	44	amod	_	_
44	affinity	affinity	NN	NN	_	38	dobj	_	_
45	for	for	IN	IN	_	46	case	_	_
46	testosterone	testosterone	NN	NN	_	44	nmod	_	_
47	(	(	-LRB-	-LRB-	_	51	punct	_	_
48	1.32	1.32	CD	CD	_	51	nummod	_	_
49	+/-	+/-	CC	CC	_	48	cc	_	_
50	0.49	0.49	CD	CD	_	48	conj	_	_
51	nM	nm	NN	NN	_	44	dep	_	_
52	;	;	:	:	_	51	punct	_	_
53	mean	mean	NN	NN	_	51	dep	_	_
54	+/-	+/-	CC	CC	_	53	cc	_	_
55	SD	sd	NN	NN	_	53	conj	_	_
56	)	)	-RRB-	-RRB-	_	51	punct	_	_
57	,	,	,	,	_	44	punct	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	2	2	LS	LS	_	63	dep	_	_
60	)	)	-RRB-	-RRB-	_	59	punct	_	_
61	a	a	DT	DT	_	63	det	_	_
62	saturable	saturable	JJ	JJ	_	63	amod	_	_
63	capacity	capacity	NN	NN	_	44	conj	_	_
64	(	(	-LRB-	-LRB-	_	69	punct	_	_
65	184	184	CD	CD	_	69	nummod	_	_
66	+/-	+/-	CC	CC	_	65	cc	_	_
67	52	52	CD	CD	_	65	conj	_	_
68	binding	bind	VBG	VBG	_	69	amod	_	_
69	sites	site	NNS	NNS	_	63	dep	_	_
70	per	per	IN	IN	_	71	case	_	_
71	cell	cell	NN	NN	_	69	nmod	_	_
72	;	;	:	:	_	69	punct	_	_
73	mean	mean	NN	NN	_	69	dep	_	_
74	+/-	+/-	CC	CC	_	73	cc	_	_
75	SD	sd	NN	NN	_	73	conj	_	_
76	)	)	-RRB-	-RRB-	_	69	punct	_	_
77	,	,	,	,	_	44	punct	_	_
78	and	and	CC	CC	_	44	cc	_	_
79	(	(	-LRB-	-LRB-	_	80	punct	_	_
80	3	3	LS	LS	_	86	dep	_	_
81	)	)	-RRB-	-RRB-	_	80	punct	_	_
82	a	a	DT	DT	_	86	det	_	_
83	characteristic	characteristic	JJ	JJ	_	86	amod	_	_
84	competitive	competitive	JJ	JJ	_	83	dep	_	_
85	binding	binding	NN	NN	_	86	compound	_	_
86	profile	profile	NN	NN	_	44	conj	_	_
87	for	for	IN	IN	_	90	case	_	_
88	other	other	JJ	JJ	_	90	amod	_	_
89	steroid	steroid	NN	NN	_	90	compound	_	_
90	hormones	hormone	NNS	NNS	_	86	nmod	_	_
91	(	(	-LRB-	-LRB-	_	94	punct	_	_
92	relative	relative	JJ	JJ	_	94	amod	_	_
93	binding	binding	NN	NN	_	94	compound	_	_
94	affinities	affinity	NNS	NNS	_	86	dep	_	_
95	:	:	:	:	_	94	punct	_	_
96	testosterone	testosterone	NN	NN	_	94	dep	_	_
97	=	=	JJ	JJ	_	96	amod	_	_
98	dihydrotestosterone	dihydrotestosterone	NN	NN	_	97	dep	_	_
99	&gt;	&gt;	JJR	JJR	_	98	amod	_	_
100	17	17	CD	CD	_	101	nummod	_	_
101	beta-estradiol	beta-estradiol	NN	NN	_	99	dep	_	_
102	&gt;	&gt;	JJR	JJR	_	101	amod	_	_
103	progesterone	progesterone	NN	NN	_	102	dep	_	_
104	,	,	,	,	_	94	punct	_	_
105	whereas	whereas	IN	IN	_	113	mark	_	_
106	aldosterone	aldosterone	NN	NN	_	113	nsubj	_	_
107	,	,	,	,	_	106	punct	_	_
108	17-hydroxy-progesterone	17-hydroxy-progesterone	NN	NN	_	106	conj	_	_
109	and	and	CC	CC	_	106	cc	_	_
110	cortisol	cortisol	NN	NN	_	106	conj	_	_
111	did	do	VBD	VBD	_	113	aux	_	_
112	not	not	RB	RB	_	113	neg	_	_
113	compete	compete	VB	VB	_	94	acl:relcl	_	_
114	appreciably	appreciably	RB	RB	_	113	advmod	_	_
115	)	)	-RRB-	-RRB-	_	94	punct	_	_
116	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	number	number	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sites	site	NNS	NNS	_	3	nmod	_	_
7	determined	determine	VBN	VBN	_	3	acl	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	-LSB-3H-RSB-dihydrotestosterone	-lsb-3h-rsb-dihydrotestosterone	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	-LSB-3H-RSB-RU-1881	-lsb-3h-rsb-ru-1881	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	-LSB-3H-RSB-testosterone	-lsb-3h-rsb-testosterone	NN	NN	_	9	conj	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	comparable	comparable	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	raises	raise	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	possibility	possibility	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	androgen	androgen	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	12	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
12	differ	differ	VBP	VBP	_	4	ccomp	_	_
13	from	from	IN	IN	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	genital	genital	JJ	JJ	_	18	amod	_	_
17	skin	skin	NN	NN	_	18	compound	_	_
18	fibroblasts	fibroblast	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	apparent	apparent	JJ	JJ	_	5	amod	_	_
5	correlation	correlation	NN	NN	_	2	nsubj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	serum	serum	NN	NN	_	9	compound	_	_
8	testosterone	testosterone	NN	NN	_	9	compound	_	_
9	concentrations	concentration	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	androgen	androgen	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	9	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	fertile	fertile	JJ	JJ	_	3	amod	_	_
3	women	woman	NNS	NNS	_	11	nmod	_	_
4	remarkable	remarkable	JJ	JJ	_	5	amod	_	_
5	changes	change	NNS	NNS	_	11	nsubjpass	_	_
6	in	in	IN	IN	_	9	case	_	_
7	androgen	androgen	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	course	course	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	menstrual	menstrual	JJ	JJ	_	18	amod	_	_
18	cycle	cycle	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	11	punct	_	_
20	with	with	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	significant	significant	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	11	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	immediate	immediate	JJ	JJ	_	27	amod	_	_
27	preovulatory	preovulatory	JJ	JJ	_	28	amod	_	_
28	period	period	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	androgen	androgen	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
10	provides	provide	VBZ	VBZ	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	first	first	JJ	JJ	_	14	amod	_	_
14	time	time	NN	NN	_	10	nmod	_	_
15	the	the	DT	DT	_	17	det	_	_
16	experimental	experimental	JJ	JJ	_	17	amod	_	_
17	basis	basis	NN	NN	_	10	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	an	a	DT	DT	_	20	det	_	_
20	hypothesis	hypothesis	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	direct	direct	JJ	JJ	_	25	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	receptor-mediated	receptor-mediated	JJ	JJ	_	22	dep	_	_
25	effects	effect	NNS	NNS	_	20	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	androgens	androgen	NNS	NNS	_	25	nmod	_	_
28	on	on	IN	IN	_	31	case	_	_
29	mature	mature	JJ	JJ	_	31	amod	_	_
30	immunocompetent	immunocompetent	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunological	immunological	JJ	JJ	_	3	amod	_	_
3	implications	implication	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	results	result	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	discussed	discuss	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Comparative	comparative	JJ	JJ	_	2	amod	_	_
2	mapping	mapping	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SRY	sry	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	great	great	JJ	JJ	_	8	amod	_	_
8	apes	ape	NNS	NNS	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Cytogenetic	cytogenetic	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	primate	primate	JJ	JJ	_	7	amod	_	_
6	Y	y	NN	NN	_	7	compound	_	_
7	chromosomes	chromosome	NNS	NNS	_	2	nmod	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	suggested	suggest	VBN	VBN	_	0	root	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	extensive	extensive	JJ	JJ	_	12	amod	_	_
12	rearrangements	rearrangement	NNS	NNS	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	occurred	occur	VBN	VBN	_	9	ccomp	_	_
15	during	during	IN	IN	_	16	case	_	_
16	evolution	evolution	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	great	great	JJ	JJ	_	20	amod	_	_
20	apes	ape	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	situ	situ	FW	FW	_	4	dep	_	_
6	hybridization	hybridization	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	define	define	VB	VB	_	3	advcl	_	_
9	these	these	DT	DT	_	10	det	_	_
10	rearrangements	rearrangement	NNS	NNS	_	8	dobj	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	level	level	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	pHU-14	phu-14	NN	NN	_	14	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	probe	probe	NN	NN	_	1	appos	_	_
5	including	include	VBG	VBG	_	6	case	_	_
6	sequences	sequence	NNS	NNS	_	4	nmod	_	_
7	from	from	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	sex	sex	NN	NN	_	12	compound	_	_
10	determining	determining	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	SRY	sry	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	hybridizes	hybridize	VBZ	VBZ	_	0	root	_	_
15	close	close	RB	RB	_	14	advmod	_	_
16	to	to	TO	TO	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	early	early	JJ	JJ	_	21	amod	_	_
19	replicating	replicate	VBG	VBG	_	21	amod	_	_
20	pseudoautosomal	pseudoautosomal	JJ	JJ	_	21	amod	_	_
21	segment	segment	NN	NN	_	15	nmod	_	_
22	in	in	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	telomeric	telomeric	JJ	JJ	_	27	amod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	subtelomeric	subtelomeric	JJ	JJ	_	24	conj	_	_
27	position	position	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	Y	y	NN	NN	_	31	compound	_	_
31	chromosomes	chromosome	NNS	NNS	_	27	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	all	all	DT	DT	_	35	det	_	_
34	great	great	JJ	JJ	_	35	amod	_	_
35	apes	ape	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	low	low	JJ	JJ	_	4	amod	_	_
3	copy	copy	NN	NN	_	4	compound	_	_
4	repeat	repeat	NN	NN	_	12	nsubjpass	_	_
5	detected	detect	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	probe	probe	NN	NN	_	9	compound	_	_
9	Fr35-II	fr35-ii	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	obviously	obviously	RB	RB	_	12	advmod	_	_
12	included	include	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Y	y	NN	NN	_	16	compound	_	_
15	chromosomal	chromosomal	NN	NN	_	16	compound	_	_
16	rearrangements	rearrangement	NNS	NNS	_	12	nmod	_	_
17	during	during	IN	IN	_	19	case	_	_
18	hominid	hominid	NN	NN	_	19	compound	_	_
19	evolution	evolution	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	combined	combine	VBN	VBN	_	2	acl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	previous	previous	JJ	JJ	_	7	amod	_	_
7	studies	study	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	suggest	suggest	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Y	y	NN	NN	_	13	compound	_	_
13	chromosome	chromosome	NN	NN	_	17	nsubj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	great	great	JJ	JJ	_	16	amod	_	_
16	apes	ape	NNS	NNS	_	13	nmod	_	_
17	has	have	VBZ	VBZ	_	9	ccomp	_	_
18	a	a	DT	DT	_	20	det	_	_
19	conserved	conserve	VBN	VBN	_	20	amod	_	_
20	region	region	NN	NN	_	17	dobj	_	_
21	including	include	VBG	VBG	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	pseudoautosomal	pseudoautosomal	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	testis-determining	testis-determining	JJ	JJ	_	28	amod	_	_
28	region	region	NN	NN	_	24	conj	_	_
29	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rest	rest	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Y	y	NN	NN	_	6	compound	_	_
6	chromosome	chromosome	NN	NN	_	2	nmod	_	_
7	has	have	VBZ	VBZ	_	8	aux	_	_
8	undergone	undergo	VBN	VBN	_	0	root	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	rearrangements	rearrangement	NNS	NNS	_	8	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	great	great	JJ	JJ	_	15	amod	_	_
15	apes	ape	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	minimal	minimal	JJ	JJ	_	5	amod	_	_
4	residual	residual	JJ	JJ	_	5	amod	_	_
5	disease	disease	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	patient	patient	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	promyelocytic	promyelocytic	JJ	JJ	_	12	amod	_	_
12	leukemia	leukemia	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	RT-PCR	rt-pcr	NN	NN	_	1	nmod	_	_
15	:	:	:	:	_	1	punct	_	_
16	necessity	necessity	NN	NN	_	1	dep	_	_
17	of	of	IN	IN	_	18	case	_	_
18	chemotherapy	chemotherapy	NN	NN	_	16	nmod	_	_
19	following	follow	VBG	VBG	_	21	case	_	_
20	ATRA	atra	NN	NN	_	21	compound	_	_
21	therapy	therapy	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	PML/RAR	pml/rar	NN	NN	_	5	compound	_	_
3	alpha	alpha	NN	NN	_	5	compound	_	_
4	fusion	fusion	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	14	nsubj	_	_
6	resulting	result	VBG	VBG	_	5	acl	_	_
7	from	from	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	t(15;17)	t(15;17)	NN	NN	_	10	compound	_	_
10	translocation	translocation	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	marker	marker	NN	NN	_	0	root	_	_
15	for	for	IN	IN	_	18	case	_	_
16	acute	acute	JJ	JJ	_	18	amod	_	_
17	promyelocytic	promyelocytic	JJ	JJ	_	18	amod	_	_
18	leukemia	leukemia	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	APL	apl	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	bone	bone	NN	NN	_	5	compound	_	_
4	marrow	marrow	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	dobj	_	_
6	by	by	IN	IN	_	10	case	_	_
7	reverse	reverse	JJ	JJ	_	10	amod	_	_
8	transcriptase-polymerase	transcriptase-polymerase	NN	NN	_	10	compound	_	_
9	chain	chain	NN	NN	_	10	compound	_	_
10	reaction	reaction	NN	NN	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RT-PCR	rt-pcr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	detect	detect	VB	VB	_	2	advcl	_	_
16	residual	residual	JJ	JJ	_	20	amod	_	_
17	PML/RAR	pml/rar	NN	NN	_	19	nmod:npmod	_	_
18	alpha	alpha	NN	NN	_	19	nmod:npmod	_	_
19	mRNA-containing	mrna-containing	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	15	dobj	_	_
21	following	follow	VBG	VBG	_	22	case	_	_
22	treatment	treatment	NN	NN	_	20	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	all-trans	all-trans	JJ	JJ	_	26	amod	_	_
25	retinoic	retinoic	JJ	JJ	_	26	amod	_	_
26	acid	acid	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	ATRA	atra	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	22	cc	_	_
31	cytotoxic	cytotoxic	JJ	JJ	_	32	amod	_	_
32	chemotherapy	chemotherapy	NN	NN	_	22	conj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	a	a	DT	DT	_	35	det	_	_
35	patient	patient	NN	NN	_	15	nmod	_	_
36	with	with	IN	IN	_	37	case	_	_
37	APL	apl	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	RT-PCR	rt-pcr	NN	NN	_	3	compound	_	_
3	assay	assay	NN	NN	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	detect	detect	VB	VB	_	0	root	_	_
6	one	one	CD	CD	_	8	nummod	_	_
7	leukemic	leukemic	JJ	JJ	_	8	amod	_	_
8	cell	cell	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	10(2)	10(2)	CD	CD	_	12	nummod	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	5	advmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	PML/RAR	pml/rar	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	9	nsubj	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	still	still	RB	RB	_	9	advmod	_	_
9	detectable	detectable	JJ	JJ	_	2	ccomp	_	_
10	despite	despite	IN	IN	_	12	case	_	_
11	clinical	clinical	JJ	JJ	_	12	amod	_	_
12	remission	remission	NN	NN	_	9	nmod	_	_
13	following	follow	VBG	VBG	_	15	case	_	_
14	ATRA	atra	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	but	but	CC	CC	_	9	cc	_	_
18	undetectable	undetectable	JJ	JJ	_	9	conj	_	_
19	following	follow	VBG	VBG	_	20	case	_	_
20	consolidation	consolidation	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	chemotherapy	chemotherapy	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	technique	technique	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	useful	useful	JJ	JJ	_	3	ccomp	_	_
9	for	for	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	identification	identification	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	minimal	minimal	JJ	JJ	_	15	amod	_	_
14	residual	residual	JJ	JJ	_	15	amod	_	_
15	disease	disease	NN	NN	_	11	nmod	_	_
16	in	in	NN	NN	_	17	dep	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	APL	apl	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	cytotoxic	cytotoxic	JJ	JJ	_	23	amod	_	_
23	chemotherapy	chemotherapy	NN	NN	_	28	nsubjpass	_	_
24	following	follow	VBG	VBG	_	26	case	_	_
25	ATRA	atra	NN	NN	_	26	compound	_	_
26	therapy	therapy	NN	NN	_	23	nmod	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	required	require	VBN	VBN	_	8	conj	_	_
29	for	for	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	elimination	elimination	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	APL	apl	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	v-src	v-src	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	correlates	correlate	VBZ	VBZ	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	8	nsubj	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	a	a	DT	DT	_	8	det	_	_
5	rapidly	rapidly	RB	RB	_	6	advmod	_	_
6	inducible	inducible	JJ	JJ	_	8	amod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activator	activator	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	responds	respond	VBZ	VBZ	_	8	acl:relcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	variety	variety	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	signals	signal	NNS	NNS	_	13	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	influences	influence	VBZ	VBZ	_	10	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	many	many	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	involved	involve	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	immune	immune	JJ	JJ	_	27	amod	_	_
27	response	response	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	kinases	kinase	NNS	NNS	_	4	nsubj	_	_
4	transmit	transmit	VBP	VBP	_	0	root	_	_
5	signals	signal	NNS	NNS	_	4	dobj	_	_
6	from	from	IN	IN	_	7	case	_	_
7	cytokine	cytokine	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immune	immune	JJ	JJ	_	7	conj	_	_
10	receptors	receptor	NNS	NNS	_	7	dep	_	_
11	.	.	.	.	_	4	punct	_	_

1	Very	very	RB	RB	_	3	advmod	_	_
2	little	little	JJ	JJ	_	3	amod	_	_
3	information	information	NN	NN	_	4	nsubj	_	_
4	exists	exist	VBZ	VBZ	_	0	root	_	_
5	linking	link	VBG	VBG	_	4	dep	_	_
6	these	these	DT	DT	_	9	det	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	classes	class	NNS	NNS	_	5	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	signaling	signal	VBG	VBG	_	12	amod	_	_
12	molecules	molecule	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	v-src	v-src	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	7	nsubj	_	_
7	correlates	correlate	VBZ	VBZ	_	3	ccomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	kappa	kappa	NN	NN	_	16	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	10	nmod	_	_
17	similar	similar	JJ	JJ	_	16	amod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	that	that	DT	DT	_	17	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	phorbol	phorbol	NN	NN	_	23	compound	_	_
23	ester	ester	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	ionomycin	ionomycin	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	7	punct	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	detected	detect	VBN	VBN	_	7	advcl	_	_
29	by	by	IN	IN	_	33	case	_	_
30	electrophoretic	electrophoretic	JJ	JJ	_	33	amod	_	_
31	mobility	mobility	NN	NN	_	33	compound	_	_
32	shift	shift	NN	NN	_	33	compound	_	_
33	assay	assay	NN	NN	_	28	nmod	_	_
34	using	use	VBG	VBG	_	33	acl	_	_
35	a	a	DT	DT	_	36	det	_	_
36	variety	variety	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	kappa	kappa	NN	NN	_	40	compound	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	sites	site	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	complex	complex	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	blocked	block	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	herbimycin	herbimycin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	appos	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	v-src-induced	v-src-induced	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	comprised	comprise	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	p50	p50	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p65	p65	NN	NN	_	6	conj	_	_
9	components	component	NNS	NNS	_	6	dep	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	determined	determine	VBN	VBN	_	4	advcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	supershift	supershift	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	immunoblot	immunoblot	NN	NN	_	17	conj	_	_
20	analysis	analysis	NN	NN	_	17	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	correlate	correlate	NN	NN	_	22	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	finding	finding	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	22	punct	_	_
9	transient	transient	JJ	JJ	_	10	amod	_	_
10	co-transfection	co-transfection	NN	NN	_	22	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
13	LTR	ltr	NN	NN	_	15	compound	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	constructs	construct	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	different	different	JJ	JJ	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	15	nmod	_	_
22	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	v-src	v-src	NN	NN	_	25	nsubj	_	_
25	activated	activate	VBD	VBD	_	22	ccomp	_	_
26	this	this	DT	DT	_	27	det	_	_
27	promoter	promoter	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	32	case	_	_
29	a	a	DT	DT	_	32	det	_	_
30	kappa	kappa	NN	NN	_	32	compound	_	_
31	B-dependent	b-dependent	JJ	JJ	_	32	amod	_	_
32	manner	manner	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	transactivation	transactivation	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	LTR	ltr	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	v-src	v-src	NN	NN	_	4	nmod	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	more	more	RBR	RBR	_	13	advmod	_	_
13	sensitive	sensitive	JJ	JJ	_	2	ccomp	_	_
14	to	to	TO	TO	_	15	case	_	_
15	mutations	mutation	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	proximal	proximal	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	rather	rather	RB	RB	_	18	cc	_	_
21	than	than	IN	IN	_	20	mwe	_	_
22	the	the	DT	DT	_	23	det	_	_
23	distal	distal	JJ	JJ	_	18	conj	_	_
24	,	,	,	,	_	18	punct	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	element	element	NN	NN	_	18	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	implications	implication	NNS	NNS	_	13	nsubjpass	_	_
3	for	for	IN	IN	_	7	case	_	_
4	T	t	NN	NN	_	7	compound	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	signaling	signaling	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	considered	consider	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Comparison	comparison	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	retinoic	retinoic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	phorbol	phorbol	NN	NN	_	8	compound	_	_
7	myristate	myristate	NN	NN	_	8	compound	_	_
8	acetate	acetate	NN	NN	_	4	conj	_	_
9	as	as	IN	IN	_	10	case	_	_
10	inducers	inducer	NNS	NNS	_	1	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Several	several	JJ	JJ	_	6	amod	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	12	nsubjpass	_	_
7	growing	grow	VBG	VBG	_	6	acl	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	7	advmod	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	differentiate	differentiate	VB	VB	_	12	xcomp	_	_
15	to	to	TO	TO	_	19	case	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	mature	mature	JJ	JJ	_	19	amod	_	_
18	monocyte/macrophage-like	monocyte/macrophage-like	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	treatment	treatment	NN	NN	_	14	nmod	_	_
22	with	with	IN	IN	_	27	case	_	_
23	protein	protein	NN	NN	_	27	compound	_	_
24	kinase	kinase	NN	NN	_	27	compound	_	_
25	C-activating	c-activating	JJ	JJ	_	27	amod	_	_
26	phorbol	phorbol	NN	NN	_	27	compound	_	_
27	esters	ester	NNS	NNS	_	21	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	such	such	JJ	JJ	_	31	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	PMA	pma	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	14	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	PMA	pma	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	cells	cell	NNS	NNS	_	14	nsubj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	THP-1	thp-1	NN	NN	_	13	compound	_	_
10	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
11	leukemia	leukemia	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	6	nmod	_	_
14	acquire	acquire	VBP	VBP	_	0	root	_	_
15	macrophage-like	macrophage-like	JJ	JJ	_	16	amod	_	_
16	characteristics	characteristic	NNS	NNS	_	14	dobj	_	_
17	after	after	IN	IN	_	18	case	_	_
18	treatment	treatment	NN	NN	_	14	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	all-trans	all-trans	JJ	JJ	_	22	amod	_	_
21	retinoic	retinoic	JJ	JJ	_	22	amod	_	_
22	acid	acid	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	RA	ra	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	analyze	analyze	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	signal	signal	NN	NN	_	6	compound	_	_
5	transduction	transduction	NN	NN	_	6	compound	_	_
6	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	RA	ra	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	first	first	RB	RB	_	13	advmod	_	_
13	compared	compare	VBD	VBD	_	2	parataxis	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	PMA	pma	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	RA	ra	NN	NN	_	17	conj	_	_
20	on	on	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	15	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	genes	gene	NNS	NNS	_	22	nmod	_	_
25	which	which	WDT	WDT	_	27	nsubjpass	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	known	know	VBN	VBN	_	24	acl:relcl	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	regulated	regulate	VBN	VBN	_	27	xcomp	_	_
31	during	during	IN	IN	_	33	case	_	_
32	monocytic	monocytic	JJ	JJ	_	33	amod	_	_
33	differentiation	differentiation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	RA	ra	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	PMA	pma	NN	NN	_	2	conj	_	_
5	effectively	effectively	RB	RB	_	6	advmod	_	_
6	down-regulated	down-regulate	VBD	VBD	_	0	root	_	_
7	c-myc	c-myc	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	while	while	IN	IN	_	13	mark	_	_
11	c-myb	c-myb	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	13	nsubj	_	_
13	decreased	decrease	VBD	VBD	_	6	advcl	_	_
14	only	only	RB	RB	_	17	advmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	PMA	pma	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	beta	beta	NN	NN	_	6	compound	_	_
5	2-integrin	2-integrin	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	CD11a	cd11a	NN	NN	_	6	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CD11b	cd11b	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	1	punct	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	clearly	clearly	RB	RB	_	14	advmod	_	_
14	increased	increase	VBN	VBN	_	0	root	_	_
15	after	after	IN	IN	_	16	case	_	_
16	both	both	DT	DT	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	treatments	treatment	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	Their	they	PRP$	PRP$	_	2	nmod:poss	_	_
2	effects	effect	NNS	NNS	_	10	nsubj	_	_
3	on	on	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	src-family	src-family	NN	NN	_	8	compound	_	_
6	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	different	different	JJ	JJ	_	0	root	_	_
11	:	:	:	:	_	10	punct	_	_
12	hck	hck	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	16	nsubjpass	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	similarly	similarly	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	10	parataxis	_	_
17	by	by	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	agents	agent	NNS	NNS	_	16	nmod	_	_
20	but	but	CC	CC	_	16	cc	_	_
21	lyn	lyn	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	24	nsubj	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	stronger	stronger	JJR	JJR	_	16	conj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	rapid	rapid	JJ	JJ	_	24	conj	_	_
28	after	after	IN	IN	_	30	case	_	_
29	RA	ra	NN	NN	_	30	compound	_	_
30	treatment	treatment	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	RA	ra	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	enhanced	enhance	VBD	VBD	_	0	root	_	_
4	lyn	lyn	NN	NN	_	6	compound	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	3	dobj	_	_
7	rapidly	rapidly	RB	RB	_	3	advmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	HL-60	hl-60	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	indicating	indicate	VBG	VBG	_	3	advcl	_	_
12	that	that	IN	IN	_	20	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	20	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	lyn	lyn	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	nmod	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	common	common	JJ	JJ	_	11	ccomp	_	_
21	in	in	IN	IN	_	22	case	_	_
22	monocytic	monocytic	JJ	JJ	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	granulocytic	granulocytic	JJ	JJ	_	22	conj	_	_
25	maturation	maturation	NN	NN	_	22	dep	_	_
26	of	of	IN	IN	_	29	case	_	_
27	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
28	leukemia	leukemia	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	AP-1	ap-1	NN	NN	_	7	compound	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	2	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	RA-induced	ra-induced	JJ	JJ	_	13	amod	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	THP-1	thp-1	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	19	nsubjpass	_	_
17	were	be	VBD	VBD	_	19	auxpass	_	_
18	transiently	transiently	RB	RB	_	19	advmod	_	_
19	transfected	transfect	VBN	VBN	_	2	parataxis	_	_
20	with	with	IN	IN	_	29	case	_	_
21	a	a	DT	DT	_	29	det	_	_
22	chloramphenicol	chloramphenicol	NN	NN	_	29	compound	_	_
23	acetyl	acetyl	NN	NN	_	29	compound	_	_
24	transferase	transferase	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	CAT	cat	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	-reporter	-reporter	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	19	nmod	_	_
30	containing	contain	VBG	VBG	_	29	acl	_	_
31	5	5	CD	CD	_	32	nummod	_	_
32	copies	copy	NNS	NNS	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	AP-1	ap-1	NN	NN	_	37	compound	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	sites	site	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	PMA	pma	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	RA	ra	NN	NN	_	9	nsubj	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	induce	induce	VB	VB	_	0	root	_	_
10	any	any	DT	DT	_	12	det	_	_
11	CAT	cat	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	thus	thus	RB	RB	_	18	advmod	_	_
18	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
19	that	that	IN	IN	_	33	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	RA-induced	ra-induced	JJ	JJ	_	22	amod	_	_
22	changes	change	NNS	NNS	_	33	nsubj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	those	those	DT	DT	_	28	det	_	_
28	genes	gene	NNS	NNS	_	25	nmod	_	_
29	described	describe	VBN	VBN	_	22	acl	_	_
30	above	above	IN	IN	_	29	advmod	_	_
31	were	be	VBD	VBD	_	33	cop	_	_
32	not	not	RB	RB	_	33	neg	_	_
33	dependent	dependent	JJ	JJ	_	18	ccomp	_	_
34	on	on	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	AP-1	ap-1	NN	NN	_	38	compound	_	_
37	enhancer	enhancer	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	9	punct	_	_

1	Antigenic	antigenic	JJ	JJ	_	2	amod	_	_
2	specificities	specificity	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	CD4+	cd4+	JJ	JJ	_	7	amod	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	clones	clone	NNS	NNS	_	2	nmod	_	_
8	recovered	recover	VBD	VBD	_	7	acl	_	_
9	from	from	IN	IN	_	17	case	_	_
10	recurrent	recurrent	JJ	JJ	_	17	amod	_	_
11	genital	genital	JJ	JJ	_	10	dep	_	_
12	herpes	herpes	NN	NN	_	17	compound	_	_
13	simplex	simplex	JJ	JJ	_	17	amod	_	_
14	virus	virus	NN	NN	_	17	compound	_	_
15	type	type	NN	NN	_	17	compound	_	_
16	2	2	CD	CD	_	17	nummod	_	_
17	lesions	lesion	NNS	NNS	_	8	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Lesions	lesion	NNS	NNS	_	14	nsubjpass	_	_
2	resulting	result	VBG	VBG	_	1	acl	_	_
3	from	from	IN	IN	_	12	case	_	_
4	recurrent	recurrent	JJ	JJ	_	12	amod	_	_
5	genital	genital	JJ	JJ	_	4	dep	_	_
6	herpes	herpes	NN	NN	_	8	compound	_	_
7	simplex	simplex	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HSV	hsv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	infection	infection	NN	NN	_	2	nmod	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	characterized	characterize	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	infiltration	infiltration	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	CD4+	cd4+	JJ	JJ	_	19	amod	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	antigenic	antigenic	JJ	JJ	_	6	amod	_	_
6	specificity	specificity	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	47	47	CD	CD	_	12	nummod	_	_
9	HSV-specific	hsv-specific	JJ	JJ	_	12	amod	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	clones	clone	NNS	NNS	_	6	nmod	_	_
13	recovered	recover	VBN	VBN	_	12	acl	_	_
14	from	from	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	HSV-2	hsv-2	NN	NN	_	13	nmod	_	_
17	buttock	buttock	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	thigh	thigh	NN	NN	_	16	conj	_	_
20	lesions	lesion	NNS	NNS	_	16	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	five	five	CD	CD	_	23	nummod	_	_
23	patients	patient	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Clones	clone	NNS	NNS	_	23	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	proliferative	proliferative	JJ	JJ	_	4	amod	_	_
4	responses	response	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	9	case	_	_
6	recombinant	recombinant	JJ	JJ	_	9	amod	_	_
7	truncated	truncate	VBN	VBN	_	9	amod	_	_
8	glycoprotein	glycoprotein	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	gB	gb	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	gD	gd	NN	NN	_	9	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	HSV-2	hsv-2	NN	NN	_	9	nmod	_	_
17	or	or	CC	CC	_	9	cc	_	_
18	purified	purify	VBN	VBN	_	20	amod	_	_
19	natural	natural	JJ	JJ	_	20	amod	_	_
20	gC	gc	NN	NN	_	9	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	HSV-2	hsv-2	NN	NN	_	20	nmod	_	_
23	comprised	comprise	VBD	VBD	_	0	root	_	_
24	a	a	DT	DT	_	25	det	_	_
25	minority	minority	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	total	total	JJ	JJ	_	29	amod	_	_
29	number	number	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	HSV-specific	hsv-specific	JJ	JJ	_	32	amod	_	_
32	clones	clone	NNS	NNS	_	29	nmod	_	_
33	isolated	isolate	VBN	VBN	_	32	acl	_	_
34	from	from	IN	IN	_	35	case	_	_
35	lesions	lesion	NNS	NNS	_	33	nmod	_	_
36	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	gC2-	gc2-	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	gD2-specific	gd2-specific	JJ	JJ	_	2	conj	_	_
5	CD4+	cd4+	JJ	JJ	_	6	amod	_	_
6	clones	clone	NNS	NNS	_	2	dep	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	cytotoxic	cytotoxic	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	approximate	approximate	JJ	JJ	_	3	amod	_	_
3	locations	location	NNS	NNS	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	HSV-2	hsv-2	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	3	nmod	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	HSV-2	hsv-2	NN	NN	_	12	compound	_	_
10	type-specific	type-specific	JJ	JJ	_	12	amod	_	_
11	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
12	antigens	antigen	NNS	NNS	_	8	dobj	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	determined	determine	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	15	advcl	_	_
18	HSV-1	hsv-1	NN	NN	_	23	compound	_	_
19	x	x	NN	NN	_	23	compound	_	_
20	HSV-2	hsv-2	NN	NN	_	23	compound	_	_
21	intertypic	intertypic	JJ	JJ	_	23	amod	_	_
22	recombinant	recombinant	JJ	JJ	_	23	amod	_	_
23	virus	virus	NN	NN	_	17	dobj	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	include	include	VBP	VBP	_	15	conj	_	_
26	the	the	DT	DT	_	29	det	_	_
27	approximate	approximate	JJ	JJ	_	29	amod	_	_
28	map	map	NN	NN	_	29	compound	_	_
29	regions	region	NNS	NNS	_	25	dobj	_	_
30	0.30	0.30	CD	CD	_	32	compound	_	_
31	to	to	TO	TO	_	32	dep	_	_
32	0.46	0.46	CD	CD	_	29	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	0.59	0.59	CD	CD	_	36	compound	_	_
35	to	to	TO	TO	_	36	dep	_	_
36	0.67	0.67	CD	CD	_	32	conj	_	_
37	,	,	,	,	_	32	punct	_	_
38	0.67	0.67	CD	CD	_	40	compound	_	_
39	to	to	TO	TO	_	40	dep	_	_
40	0.73	0.73	CD	CD	_	32	conj	_	_
41	,	,	,	,	_	32	punct	_	_
42	and	and	CC	CC	_	32	cc	_	_
43	0.82	0.82	CD	CD	_	45	compound	_	_
44	to	to	TO	TO	_	45	dep	_	_
45	1.0	1.0	CD	CD	_	32	conj	_	_
46	units	unit	NNS	NNS	_	32	dep	_	_
47	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	antigenic	antigenic	JJ	JJ	_	3	amod	_	_
3	specificity	specificity	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	12	case	_	_
5	an	a	DT	DT	_	12	det	_	_
6	HLA	hla	NN	NN	_	12	compound	_	_
7	DQ2-restricted	dq2-restricted	JJ	JJ	_	12	amod	_	_
8	,	,	,	,	_	12	punct	_	_
9	HSV-2	hsv-2	NN	NN	_	12	compound	_	_
10	type-specific	type-specific	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	clone	clone	NN	NN	_	3	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	mapped	map	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	amino	amino	NN	NN	_	17	compound	_	_
17	acids	acid	NNS	NNS	_	14	nmod	_	_
18	425	425	CD	CD	_	17	nummod	_	_
19	to	to	TO	TO	_	17	dep	_	_
20	444	444	CD	CD	_	17	nummod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	VP16	vp16	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	HSV-2	hsv-2	NN	NN	_	22	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	sequential	sequential	JJ	JJ	_	27	amod	_	_
27	use	use	NN	NN	_	14	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	an	a	DT	DT	_	32	det	_	_
30	intertypic	intertypic	JJ	JJ	_	32	amod	_	_
31	recombinant	recombinant	JJ	JJ	_	32	amod	_	_
32	virus	virus	NN	NN	_	27	nmod	_	_
33	containing	contain	VBG	VBG	_	32	acl	_	_
34	VP16	vp16	NN	NN	_	33	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	HSV-2	hsv-2	NN	NN	_	34	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	an	a	DT	DT	_	40	det	_	_
39	HSV-1	hsv-1	NN	NN	_	40	compound	_	_
40	background	background	NN	NN	_	36	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	recombinant	recombinant	JJ	JJ	_	45	amod	_	_
43	VP16	vp16	NN	NN	_	45	compound	_	_
44	fusion	fusion	NN	NN	_	45	compound	_	_
45	proteins	protein	NNS	NNS	_	40	conj	_	_
46	,	,	,	,	_	40	punct	_	_
47	and	and	CC	CC	_	40	cc	_	_
48	synthetic	synthetic	JJ	JJ	_	49	amod	_	_
49	peptides	peptide	NNS	NNS	_	40	conj	_	_
50	.	.	.	.	_	14	punct	_	_

1	Each	each	DT	DT	_	8	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	remaining	remain	VBG	VBG	_	6	amod	_	_
5	four	four	CD	CD	_	6	nummod	_	_
6	patients	patient	NNS	NNS	_	1	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	yielded	yield	VBD	VBD	_	0	root	_	_
9	at	at	IN	IN	_	10	case	_	_
10	least	least	JJS	JJS	_	11	nmod:npmod	_	_
11	one	one	CD	CD	_	14	nummod	_	_
12	type-specific	type-specific	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	clone	clone	NN	NN	_	8	dobj	_	_
15	reactive	reactive	JJ	JJ	_	14	amod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	HSV-2	hsv-2	NN	NN	_	19	compound	_	_
19	epitope	epitope	NN	NN	_	15	nmod	_	_
20	mapping	map	VBG	VBG	_	19	acl	_	_
21	to	to	TO	TO	_	27	case	_	_
22	approximately	approximately	RB	RB	_	25	advmod	_	_
23	0.67	0.67	CD	CD	_	25	compound	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	0.73	0.73	CD	CD	_	27	nummod	_	_
26	map	map	NN	NN	_	27	compound	_	_
27	units	unit	NNS	NNS	_	20	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	antigenic	antigenic	JJ	JJ	_	3	amod	_	_
3	specificities	specificity	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	lesion-derived	lesion-derived	JJ	JJ	_	8	amod	_	_
6	CD4+	cd4+	JJ	JJ	_	8	amod	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	clones	clone	NNS	NNS	_	3	nmod	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	quite	quite	RB	RB	_	11	advmod	_	_
11	diverse	diverse	JJ	JJ	_	0	root	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	include	include	VBP	VBP	_	11	conj	_	_
14	at	at	IN	IN	_	15	case	_	_
15	least	least	JJS	JJS	_	16	nmod:npmod	_	_
16	10	10	CD	CD	_	17	nummod	_	_
17	epitopes	epitope	NNS	NNS	_	13	dobj	_	_
18	.	.	.	.	_	11	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	10	nsubjpass	_	_
4	reactive	reactive	JJ	JJ	_	3	amod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	gC	gc	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	VP16	vp16	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	reported	report	VBN	VBN	_	0	root	_	_
11	here	here	RB	RB	_	10	advmod	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	first	first	JJ	JJ	_	15	amod	_	_
15	time	time	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Encephalomyocarditis	encephalomyocarditis	NN	NN	_	8	compound	_	_
2	virus	virus	NN	NN	_	8	compound	_	_
3	internal	internal	JJ	JJ	_	8	amod	_	_
4	ribosomal	ribosomal	JJ	JJ	_	8	amod	_	_
5	entry	entry	NN	NN	_	8	compound	_	_
6	site	site	NN	NN	_	8	compound	_	_
7	RNA-protein	rna-protein	JJ	JJ	_	8	amod	_	_
8	interactions	interaction	NNS	NNS	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Translational	translational	JJ	JJ	_	2	amod	_	_
2	initiation	initiation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	encephalomyocarditis	encephalomyocarditis	NN	NN	_	9	compound	_	_
5	virus	virus	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	EMCV	emcv	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	mRNA	mrna	NN	NN	_	2	nmod	_	_
10	occurs	occur	VBZ	VBZ	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	ribosomal	ribosomal	JJ	JJ	_	13	amod	_	_
13	entry	entry	NN	NN	_	10	nmod	_	_
14	into	into	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	5'	5'	NN	NN	_	18	compound	_	_
17	nontranslated	nontranslated	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	EMCV	emcv	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	rather	rather	RB	RB	_	13	cc	_	_
25	than	than	IN	IN	_	24	mwe	_	_
26	by	by	IN	IN	_	28	case	_	_
27	ribosomal	ribosomal	JJ	JJ	_	28	amod	_	_
28	scanning	scanning	NN	NN	_	13	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	Internal	internal	JJ	JJ	_	3	amod	_	_
2	ribosomal	ribosomal	JJ	JJ	_	3	amod	_	_
3	binding	binding	NN	NN	_	4	nsubj	_	_
4	requires	require	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	cis-acting	cis-acting	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	4	dobj	_	_
8	termed	term	VBN	VBN	_	7	acl	_	_
9	the	the	DT	DT	_	13	det	_	_
10	internal	internal	JJ	JJ	_	13	amod	_	_
11	ribosomal	ribosomal	JJ	JJ	_	13	amod	_	_
12	entry	entry	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	xcomp	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IRES	ires	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	4	punct	_	_

1	IRES	ire	NNS	NNS	_	2	compound	_	_
2	elements	element	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	proposed	propose	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	5	xcomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	translation	translation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	picornavirus	picornavirus	NN	NN	_	14	compound	_	_
14	mRNAs	mrna	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	some	some	DT	DT	_	18	det	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	mRNAs	mrna	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	5	punct	_	_

1	Internal	internal	JJ	JJ	_	3	amod	_	_
2	ribosome	ribosome	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	5	nsubj	_	_
4	likely	likely	RB	RB	_	5	advmod	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	interaction	interaction	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	trans-acting	trans-acting	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	recognize	recognize	VBP	VBP	_	10	acl:relcl	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mRNA	mrna	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	ribosomal	ribosomal	JJ	JJ	_	19	amod	_	_
19	complex	complex	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Five	five	CD	CD	_	3	nummod	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	16	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	p52	p52	NN	NN	_	3	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	p57	p57	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	p70	p70	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	p72	p72	NN	NN	_	5	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	p100	p100	NN	NN	_	5	conj	_	_
15	)	)	-RRB-	-RRB-	_	5	punct	_	_
16	cross-link	cross-link	VBP	VBP	_	0	root	_	_
17	the	the	DT	DT	_	19	det	_	_
18	EMCV	emcv	NN	NN	_	19	compound	_	_
19	IRES	ires	NN	NN	_	16	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	fragments	fragment	NNS	NNS	_	19	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	IRES	ires	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	one	one	CD	CD	_	13	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	p57	p57	NN	NN	_	2	appos	_	_
8	,	,	,	,	_	13	punct	_	_
9	binding	bind	VBG	VBG	_	13	nsubj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	IRES	ires	NN	NN	_	9	nmod	_	_
13	correlates	correlate	VBZ	VBZ	_	0	root	_	_
14	with	with	IN	IN	_	15	case	_	_
15	translation	translation	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	p57	p57	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	mark	_	_
7	be	be	VB	VB	_	9	cop	_	_
8	very	very	RB	RB	_	9	advmod	_	_
9	similar	similar	JJ	JJ	_	5	xcomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	if	if	IN	IN	_	12	mark	_	_
12	not	not	RB	RB	_	9	dep	_	_
13	identical	identical	JJ	JJ	_	12	dep	_	_
14	,	,	,	,	_	9	punct	_	_
15	to	to	TO	TO	_	18	case	_	_
16	polypyrimidine	polypyrimidine	NN	NN	_	18	compound	_	_
17	tract-binding	tract-binding	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	40	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cross-linking	cross-linking	JJ	JJ	_	6	amod	_	_
6	results	result	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	12	case	_	_
8	21	21	CD	CD	_	12	nummod	_	_
9	different	different	JJ	JJ	_	12	amod	_	_
10	EMCV	emcv	NN	NN	_	12	compound	_	_
11	IRES	ires	NN	NN	_	12	compound	_	_
12	fragments	fragment	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	cytoplasmic	cytoplasmic	JJ	JJ	_	16	amod	_	_
15	HeLa	hela	NN	NN	_	16	compound	_	_
16	extract	extract	NN	NN	_	12	conj	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	rabbit	rabbit	NN	NN	_	20	compound	_	_
19	reticulocyte	reticulocyte	NN	NN	_	20	compound	_	_
20	lysate	lysate	NN	NN	_	16	conj	_	_
21	as	as	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	source	source	NN	NN	_	6	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	polypeptides	polypeptide	NNS	NNS	_	23	nmod	_	_
26	,	,	,	,	_	40	punct	_	_
27	consensus	consensus	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	sites	site	NNS	NNS	_	40	nsubjpass	_	_
30	for	for	IN	IN	_	31	case	_	_
31	p52	p52	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	p57	p57	NN	NN	_	31	conj	_	_
34	,	,	,	,	_	31	punct	_	_
35	p70	p70	NN	NN	_	31	conj	_	_
36	,	,	,	,	_	31	punct	_	_
37	and	and	CC	CC	_	31	cc	_	_
38	p100	p100	NN	NN	_	31	conj	_	_
39	are	be	VBP	VBP	_	40	auxpass	_	_
40	proposed	propose	VBN	VBN	_	0	root	_	_
41	.	.	.	.	_	40	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	suggested	suggest	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	each	each	DT	DT	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	recognizes	recognize	VBZ	VBZ	_	3	ccomp	_	_
10	primarily	primarily	RB	RB	_	9	advmod	_	_
11	a	a	DT	DT	_	13	det	_	_
12	structural	structural	JJ	JJ	_	13	amod	_	_
13	feature	feature	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	RNA	rna	NN	NN	_	13	nmod	_	_
17	rather	rather	RB	RB	_	13	cc	_	_
18	than	than	IN	IN	_	17	mwe	_	_
19	a	a	DT	DT	_	21	det	_	_
20	specific	specific	JJ	JJ	_	21	amod	_	_
21	sequence	sequence	NN	NN	_	13	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	7	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
3	virus	virus	NN	NN	_	7	compound	_	_
4	type	type	NN	NN	_	7	compound	_	_
5	1	1	CD	CD	_	7	nummod	_	_
6	Nef	nef	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	8	nsubj	_	_
8	down-regulates	down-regulate	VBZ	VBZ	_	0	root	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	8	dobj	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	AP-1	ap-1	NN	NN	_	12	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	8	nmod	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	8	advmod	_	_
21	after	after	IN	IN	_	24	case	_	_
22	T-cell	t-cell	NN	NN	_	24	compound	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	stimulation	stimulation	NN	NN	_	8	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	16	nsubjpass	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	4	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Nef	nef	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	shown	show	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	down-regulate	down-regulate	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	dobj	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	21	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	AP-1	ap-1	NN	NN	_	23	conj	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	18	advmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	action	action	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Nef	nef	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	the	the	DT	DT	_	15	det	_	_
13	signal	signal	NN	NN	_	15	compound	_	_
14	transduction	transduction	NN	NN	_	15	compound	_	_
15	pathways	pathway	NNS	NNS	_	31	nsubjpass	_	_
16	which	which	WDT	WDT	_	19	nsubjpass	_	_
17	may	may	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	affected	affect	VBN	VBN	_	15	acl:relcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	constitutive	constitutive	JJ	JJ	_	25	amod	_	_
25	expression	expression	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	nef	nef	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	25	nmod	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	examined	examine	VBN	VBN	_	2	parataxis	_	_
32	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	tumor	tumor	NN	NN	_	8	compound	_	_
7	necrosis	necrosis	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	interleukin-1	interleukin-1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	lipopolysaccharide	lipopolysaccharide	NN	NN	_	8	conj	_	_
14	resulted	result	VBD	VBD	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	recruitment	recruitment	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	factors	factor	NNS	NNS	_	17	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	similar	similar	JJ	JJ	_	24	amod	_	_
24	level	level	NN	NN	_	20	nmod	_	_
25	whether	whether	IN	IN	_	30	mark	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	not	not	RB	RB	_	25	mwe	_	_
28	the	the	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	30	nsubj	_	_
30	expressed	express	VBD	VBD	_	14	advcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	nef	nef	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	14	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	23	nmod	_	_
5	,	,	,	,	_	23	punct	_	_
6	stimulation	stimulation	NN	NN	_	23	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	mitogens	mitogen	NNS	NNS	_	6	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	antibodies	antibody	NNS	NNS	_	11	conj	_	_
14	to	to	TO	TO	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	T-cell	t-cell	NN	NN	_	22	compound	_	_
17	receptor	receptor	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	TCR	tcr	NN	NN	_	22	compound	_	_
20	)	)	-RRB-	-RRB-	_	22	punct	_	_
21	-CD3	-cd3	NN	NN	_	22	compound	_	_
22	complex	complex	NN	NN	_	13	nmod	_	_
23	resulted	result	VBD	VBD	_	0	root	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	down-regulation	down-regulation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	factors	factor	NNS	NNS	_	26	nmod	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	29	dep	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	AP-1	ap-1	NN	NN	_	31	conj	_	_
34	in	in	IN	IN	_	35	case	_	_
35	cells	cell	NNS	NNS	_	29	nmod	_	_
36	expressing	express	VBG	VBG	_	35	acl	_	_
37	the	the	DT	DT	_	39	det	_	_
38	nef	nef	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	36	dobj	_	_
40	compared	compare	VBN	VBN	_	42	case	_	_
41	with	with	IN	IN	_	42	case	_	_
42	cells	cell	NNS	NNS	_	35	nmod	_	_
43	not	not	RB	RB	_	44	neg	_	_
44	expressing	express	VBG	VBG	_	42	acl	_	_
45	the	the	DT	DT	_	47	det	_	_
46	nef	nef	NN	NN	_	47	compound	_	_
47	gene	gene	NN	NN	_	44	dobj	_	_
48	.	.	.	.	_	23	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	Nef	nef	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	7	nsubj	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	affect	affect	VB	VB	_	17	advcl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD3-TCR	cd3-tcr	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	conclude	conclude	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Nef	nef	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	22	nsubj	_	_
22	down-regulates	down-regulate	VBZ	VBZ	_	17	ccomp	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	factors	factor	NNS	NNS	_	22	dobj	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	25	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	AP-1	ap-1	NN	NN	_	27	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	25	nmod	_	_
33	in	in	FW	FW	_	34	compound	_	_
34	vitro	vitro	FW	FW	_	22	advmod	_	_
35	through	through	IN	IN	_	37	case	_	_
36	an	a	DT	DT	_	37	det	_	_
37	effect	effect	NN	NN	_	22	nmod	_	_
38	on	on	IN	IN	_	43	case	_	_
39	the	the	DT	DT	_	43	det	_	_
40	TCR-dependent	tcr-dependent	JJ	JJ	_	43	amod	_	_
41	signal	signal	NN	NN	_	43	compound	_	_
42	transduction	transduction	NN	NN	_	43	compound	_	_
43	pathway	pathway	NN	NN	_	37	nmod	_	_
44	.	.	.	.	_	17	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	encoding	encoding	NN	NN	_	5	dep	_	_
7	LBR	lbr	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	an	a	DT	DT	_	11	det	_	_
10	integral	integral	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	appos	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
15	envelope	envelope	NN	NN	_	17	compound	_	_
16	inner	inner	JJ	JJ	_	17	amod	_	_
17	membrane	membrane	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	characterized	characterize	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	gene	gene	NN	NN	_	3	dobj	_	_
7	encoding	encoding	NN	NN	_	6	dep	_	_
8	LBR	lbr	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	an	a	DT	DT	_	12	det	_	_
11	integral	integral	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	8	appos	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
16	envelope	envelope	NN	NN	_	18	compound	_	_
17	inner	inner	JJ	JJ	_	18	amod	_	_
18	membrane	membrane	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Restriction	restriction	NN	NN	_	2	compound	_	_
2	mapping	mapping	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	unit	unit	NN	NN	_	8	nsubj	_	_
8	spans	span	VBZ	VBZ	_	3	ccomp	_	_
9	approximately	approximately	RB	RB	_	10	advmod	_	_
10	35	35	CD	CD	_	11	nummod	_	_
11	kilobases	kilobase	NNS	NNS	_	8	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	start	start	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	located	located	JJ	JJ	_	0	root	_	_
7	approximately	approximately	RB	RB	_	10	advmod	_	_
8	4	4	CD	CD	_	10	nummod	_	_
9	kilobases	kilobase	NNS	NNS	_	10	compound	_	_
10	5'	5'	NN	NN	_	6	dep	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	translation	translation	NN	NN	_	15	compound	_	_
14	initiation	initiation	NN	NN	_	15	compound	_	_
15	codon	codon	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	an	a	DT	DT	_	20	det	_	_
19	RNA	rna	NN	NN	_	20	compound	_	_
20	splice	splice	NN	NN	_	24	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	3863	3863	CD	CD	_	23	nummod	_	_
23	bases	basis	NNS	NNS	_	20	nmod	_	_
24	occurs	occur	VBZ	VBZ	_	6	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	5'-untranslated	5'-untranslated	JJ	JJ	_	28	amod	_	_
28	region	region	NN	NN	_	24	nmod	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	generate	generate	VB	VB	_	24	xcomp	_	_
31	mature	mature	JJ	JJ	_	34	amod	_	_
32	HeLa	hela	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	mRNA	mrna	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	6	punct	_	_

1	5'	5'	NN	NN	_	11	nsubj	_	_
2	to	to	TO	TO	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	identified	identify	VBN	VBN	_	7	amod	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	start	start	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	1	nmod	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	CCAAT	ccaat	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	0	root	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	potential	potential	JJ	JJ	_	15	amod	_	_
14	recognition	recognition	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	11	conj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	several	several	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	Sp1	sp1	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	AP-1	ap-1	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	AP-2	ap-2	NN	NN	_	21	conj	_	_
26	,	,	,	,	_	21	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	NF-kB	nf-kb	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	are	be	VBP	VBP	_	0	root	_	_
3	13	13	CD	CD	_	6	nummod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	coding	coding	NN	NN	_	6	compound	_	_
6	exons	exon	NNS	NNS	_	2	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	LBR	lbr	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	LBR	lbr	NN	NN	_	4	nmod:poss	_	_
2	's	's	POS	POS	_	4	case	_	_
3	nucleoplasmic	nucleoplasmic	JJ	JJ	_	4	amod	_	_
4	domain	domain	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	encoded	encode	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	exons	exon	NNS	NNS	_	6	nmod	_	_
9	1-4	1-4	CD	CD	_	8	nummod	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
13	hydrophobic	hydrophobic	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	23	nsubjpass	_	_
15	,	,	,	,	_	14	punct	_	_
16	with	with	IN	IN	_	20	case	_	_
17	eight	eight	CD	CD	_	20	nummod	_	_
18	putative	putative	JJ	JJ	_	20	amod	_	_
19	transmembrane	transmembrane	NN	NN	_	20	compound	_	_
20	segments	segment	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	encoded	encode	VBN	VBN	_	6	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	exons	exon	NNS	NNS	_	23	nmod	_	_
26	5-13	5-13	CD	CD	_	25	nummod	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	hydrophobic	hydrophobic	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	homologous	homologous	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	yeast	yeast	NN	NN	_	9	compound	_	_
9	polypeptides	polypeptide	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
12	that	that	IN	IN	_	19	mark	_	_
13	this	this	DT	DT	_	16	det	_	_
14	higher	higher	JJR	JJR	_	16	amod	_	_
15	eukaryotic	eukaryotic	JJ	JJ	_	16	amod	_	_
16	gene	gene	NN	NN	_	19	nsubj	_	_
17	could	could	MD	MD	_	19	aux	_	_
18	have	have	VB	VB	_	19	aux	_	_
19	evolved	evolve	VBN	VBN	_	11	ccomp	_	_
20	from	from	IN	IN	_	21	case	_	_
21	recombination	recombination	NN	NN	_	19	nmod	_	_
22	between	between	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	gene	gene	NN	NN	_	21	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	encoded	encode	VBD	VBD	_	24	ccomp	_	_
27	a	a	DT	DT	_	30	det	_	_
28	soluble	soluble	JJ	JJ	_	30	amod	_	_
29	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
30	protein	protein	NN	NN	_	26	dobj	_	_
31	and	and	CC	CC	_	24	cc	_	_
32	a	a	DT	DT	_	35	det	_	_
33	membrane	membrane	NN	NN	_	35	compound	_	_
34	protein	protein	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	24	conj	_	_
36	similar	similar	JJ	JJ	_	35	amod	_	_
37	to	to	TO	TO	_	38	case	_	_
38	those	those	DT	DT	_	36	nmod	_	_
39	in	in	IN	IN	_	40	case	_	_
40	yeast	yeast	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	structural	structural	JJ	JJ	_	10	amod	_	_
10	organization	organization	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	vertebrate	vertebrate	JJ	JJ	_	14	amod	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	encoding	encode	VBG	VBG	_	14	acl	_	_
16	an	a	DT	DT	_	19	det	_	_
17	integral	integral	JJ	JJ	_	19	amod	_	_
18	membrane	membrane	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	15	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	envelope	envelope	NN	NN	_	19	nmod	_	_
24	that	that	WDT	WDT	_	28	nsubj	_	_
25	may	may	MD	MD	_	28	aux	_	_
26	be	be	VB	VB	_	28	cop	_	_
27	a	a	DT	DT	_	28	det	_	_
28	member	member	NN	NN	_	23	acl:relcl	_	_
29	of	of	IN	IN	_	31	case	_	_
30	a	a	DT	DT	_	31	det	_	_
31	family	family	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	polypeptides	polypeptide	NNS	NNS	_	31	nmod	_	_
34	conserved	conserve	VBN	VBN	_	33	amod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	evolution	evolution	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	Sp1	sp1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	critical	critical	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	CD14	cd14	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	CD14	cd14	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	membrane	membrane	NN	NN	_	5	compound	_	_
5	glycoprotein	glycoprotein	NN	NN	_	0	root	_	_
6	expressed	express	VBN	VBN	_	5	acl	_	_
7	specifically	specifically	RB	RB	_	6	advmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	macrophages	macrophage	NNS	NNS	_	9	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	expression	expression	NN	NN	_	18	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	markedly	markedly	RB	RB	_	18	advmod	_	_
18	increased	increase	VBN	VBN	_	5	conj	_	_
19	during	during	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	process	process	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	monocyte	monocyte	NN	NN	_	24	compound	_	_
24	differentiation	differentiation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	study	study	VB	VB	_	14	advcl	_	_
5	CD14	cd14	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	14	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	CD14	cd14	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	cloned	clone	VBN	VBN	_	0	root	_	_
15	from	from	IN	IN	_	22	case	_	_
16	a	a	DT	DT	_	22	det	_	_
17	partial	partial	JJ	JJ	_	22	amod	_	_
18	EcoRI	ecori	NN	NN	_	22	compound	_	_
19	digested	digested	JJ	JJ	_	22	amod	_	_
20	chromosome	chromosome	NN	NN	_	22	compound	_	_
21	5	5	CD	CD	_	22	nummod	_	_
22	library	library	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	5.5-kilobase	5.5-kilobase	JJ	JJ	_	4	amod	_	_
3	genomic	genomic	JJ	JJ	_	4	amod	_	_
4	clone	clone	NN	NN	_	5	nsubj	_	_
5	contained	contain	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	10	det	_	_
7	full-length	full-length	JJ	JJ	_	10	amod	_	_
8	CD14	cd14	NN	NN	_	10	compound	_	_
9	coding	coding	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	5	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	4.2	4.2	CD	CD	_	16	nummod	_	_
13	kilobases	kilobase	NNS	NNS	_	16	compound	_	_
14	of	of	IN	IN	_	16	amod	_	_
15	5'-upstream	5'-upstream	JJ	JJ	_	16	amod	_	_
16	sequence	sequence	NN	NN	_	10	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	major	major	JJ	JJ	_	10	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	one	one	CD	CD	_	5	nummod	_	_
5	minor	minor	JJ	JJ	_	2	conj	_	_
6	transcription	transcription	NN	NN	_	8	compound	_	_
7	start	start	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	2	dep	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	101	101	CD	CD	_	17	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	130	130	CD	CD	_	11	conj	_	_
14	base	base	NN	NN	_	17	compound	_	_
15	pairs	pair	NNS	NNS	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	bp	bp	NN	NN	_	19	nmod:npmod	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	upstream	upstream	RB	RB	_	10	advmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	respectively	respectively	RB	RB	_	10	advmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	from	from	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	protein	protein	NN	NN	_	28	compound	_	_
26	translation	translation	NN	NN	_	28	compound	_	_
27	start	start	NN	NN	_	28	compound	_	_
28	ATG	atg	NN	NN	_	10	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	fragment	fragment	NN	NN	_	10	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	128	128	CD	CD	_	9	nummod	_	_
6	bp	bp	NN	NN	_	9	compound	_	_
7	of	of	IN	IN	_	9	amod	_	_
8	upstream	upstream	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	4	dobj	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	strong	strong	JJ	JJ	_	15	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	monocyte-specific	monocyte-specific	JJ	JJ	_	11	dep	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	10	dobj	_	_
16	in	in	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	CD14	cd14	NN	NN	_	22	compound	_	_
19	positive	positive	JJ	JJ	_	22	amod	_	_
20	monocytic	monocytic	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	10	nmod	_	_
23	Mono	mono	NN	NN	_	24	compound	_	_
24	Mac	mac	NN	NN	_	22	dep	_	_
25	6	6	CD	CD	_	24	nummod	_	_
26	as	as	IN	IN	_	27	mark	_	_
27	compared	compare	VBN	VBN	_	22	dep	_	_
28	to	to	TO	TO	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	nonmonocytic	nonmonocytic	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	27	nmod	_	_
33	HeLa	hela	NN	NN	_	32	dep	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	REX	rex	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	10	punct	_	_

1	Four	four	CD	CD	_	2	nummod	_	_
2	regions	region	NNS	NNS	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	fragment	fragment	NN	NN	_	2	nmod	_	_
7	interact	interact	VBP	VBP	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	isolated	isolate	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	14	case	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Sp1	sp1	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	regions	region	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD14	cd14	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Mutation	mutation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	major	major	JJ	JJ	_	7	amod	_	_
5	Sp1	sp1	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	-110	-110	CD	CD	_	10	nummod	_	_
10	bp	bp	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	decreased	decrease	VBD	VBD	_	0	root	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	15	amod	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	these	these	DT	DT	_	19	det	_	_
19	results	result	NNS	NNS	_	26	nsubj	_	_
20	,	,	,	,	_	19	punct	_	_
21	together	together	RB	RB	_	24	advmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	transactivation	transactivation	NN	NN	_	24	compound	_	_
24	experiments	experiment	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	demonstrate	demonstrate	VBP	VBP	_	12	conj	_	_
27	that	that	IN	IN	_	29	mark	_	_
28	Sp1	sp1	NN	NN	_	29	nsubj	_	_
29	plays	play	VBZ	VBZ	_	26	ccomp	_	_
30	a	a	DT	DT	_	32	det	_	_
31	critical	critical	JJ	JJ	_	32	amod	_	_
32	role	role	NN	NN	_	29	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	tissue-specific	tissue-specific	JJ	JJ	_	36	amod	_	_
36	expression	expression	NN	NN	_	29	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	CD14	cd14	NN	NN	_	36	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	monocytic	monocytic	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	36	nmod	_	_
42	.	.	.	.	_	12	punct	_	_

1	CD14	cd14	NN	NN	_	4	compound	_	_
2	Sp1	sp1	NN	NN	_	4	compound	_	_
3	site	site	NN	NN	_	4	compound	_	_
4	oligonucleotides	oligonucleotide	NNS	NNS	_	5	nsubj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	preferentially	preferentially	RB	RB	_	11	advmod	_	_
7	to	to	TO	TO	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	105-kDa	105-kda	JJ	JJ	_	11	amod	_	_
10	Sp1	sp1	NN	NN	_	11	compound	_	_
11	species	species	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	present	present	JJ	JJ	_	11	acl:relcl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	higher	higher	JJR	JJR	_	19	amod	_	_
18	relative	relative	JJ	JJ	_	19	amod	_	_
19	levels	level	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytic	monocytic	JJ	JJ	_	19	nmod	_	_
22	than	than	IN	IN	_	24	case	_	_
23	non-monocytic	non-monocytic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	suggesting	suggest	VBG	VBG	_	15	xcomp	_	_
27	that	that	IN	IN	_	37	mark	_	_
28	modification	modification	NN	NN	_	37	nsubj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	Sp1	sp1	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	28	punct	_	_
32	such	such	JJ	JJ	_	34	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	phosphorylation	phosphorylation	NN	NN	_	28	nmod	_	_
35	,	,	,	,	_	28	punct	_	_
36	may	may	MD	MD	_	37	aux	_	_
37	explain	explain	VB	VB	_	26	ccomp	_	_
38	how	how	WRB	WRB	_	42	advmod	_	_
39	the	the	DT	DT	_	41	det	_	_
40	Sp1	sp1	NN	NN	_	41	compound	_	_
41	site	site	NN	NN	_	42	nsubj	_	_
42	mediates	mediate	VBZ	VBZ	_	37	ccomp	_	_
43	monocytic	monocytic	JJ	JJ	_	44	amod	_	_
44	specific	specific	JJ	JJ	_	46	amod	_	_
45	promoter	promoter	NN	NN	_	46	compound	_	_
46	activity	activity	NN	NN	_	42	dobj	_	_
47	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	serine/threonine	serine/threonine	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	1	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	phosphorylates	phosphorylate	VBZ	VBZ	_	6	acl:relcl	_	_
9	c-Fos	c-fos	NN	NN	_	8	dobj	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	stimulation	stimulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	T	t	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	B	b	NN	NN	_	13	conj	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	dep	_	_
17	via	via	IN	IN	_	18	case	_	_
18	antigen	antigen	NN	NN	_	11	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	1	punct	_	_

1	Ligation	ligation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Ag	ag	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	T	t	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	B	b	NN	NN	_	6	conj	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	dep	_	_
10	initiates	initiate	VBZ	VBZ	_	0	root	_	_
11	signal	signal	NN	NN	_	13	compound	_	_
12	transduction	transduction	NN	NN	_	13	compound	_	_
13	cascades	cascade	NNS	NNS	_	10	dobj	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	alter	alter	VBP	VBP	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	genes	gene	NNS	NNS	_	17	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	regulate	regulate	VBP	VBP	_	19	acl:relcl	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	proliferation	proliferation	NN	NN	_	21	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	differentiation	differentiation	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	transmission	transmission	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	signals	signal	NNS	NNS	_	2	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	membrane	membrane	NN	NN	_	2	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	principally	principally	RB	RB	_	12	advmod	_	_
14	through	through	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	action	action	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	protein	protein	NN	NN	_	16	nmod	_	_
19	tyrosine	tyrosine	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	serine/threonine	serine/threonine	NN	NN	_	22	compound	_	_
22	kinases	kinase	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	characterized	characterize	VBN	VBN	_	3	conj	_	_
6	a	a	DT	DT	_	9	det	_	_
7	novel	novel	JJ	JJ	_	9	amod	_	_
8	serine/threonine	serine/threonine	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	3	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	phosphorylated	phosphorylate	VBD	VBD	_	9	acl:relcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	proto-oncogene	proto-oncogene	NN	NN	_	14	compound	_	_
14	product	product	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	c-Fos	c-fos	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	termed	term	VBN	VBN	_	11	conj	_	_
21	Fos	fos	NN	NN	_	22	compound	_	_
22	kinase	kinase	NN	NN	_	20	xcomp	_	_
23	.	.	.	.	_	3	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	rapidly	rapidly	RB	RB	_	5	advmod	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	after	after	IN	IN	_	7	case	_	_
7	ligation	ligation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	CD3	cd3	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CD2	cd2	NN	NN	_	10	conj	_	_
13	receptors	receptor	NNS	NNS	_	10	dep	_	_
14	in	in	IN	IN	_	15	case	_	_
15	Jurkat	jurkat	NN	NN	_	7	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	normal	normal	JJ	JJ	_	20	amod	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	in	in	IN	IN	_	23	case	_	_
23	response	response	NN	NN	_	7	conj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	IL-6	il-6	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	anti-IgM	anti-igm	NN	NN	_	25	conj	_	_
28	in	in	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	human	human	JJ	JJ	_	33	amod	_	_
31	B	b	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	25	nmod	_	_
34	AF10	af10	NN	NN	_	33	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	Ramos	ramos	NN	NN	_	34	conj	_	_
37	,	,	,	,	_	23	punct	_	_
38	respectively	respectively	RB	RB	_	5	advmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	phorbol	phorbol	NN	NN	_	3	compound	_	_
3	ester	ester	NN	NN	_	11	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	PMA	pma	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	was	be	VBD	VBD	_	11	cop	_	_
8	also	also	RB	RB	_	11	advmod	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	inducer	inducer	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	15	case	_	_
13	Fos	fos	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	all	all	DT	DT	_	11	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	above	above	JJ	JJ	_	21	amod	_	_
21	populations	population	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	11	punct	_	_
23	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
24	that	that	IN	IN	_	26	mark	_	_
25	PKC	pkc	NN	NN	_	26	nsubj	_	_
26	plays	play	VBZ	VBZ	_	23	ccomp	_	_
27	a	a	DT	DT	_	28	det	_	_
28	role	role	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	regulation	regulation	NN	NN	_	26	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	this	this	DT	DT	_	34	det	_	_
34	enzyme	enzyme	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	3	nsubj	_	_
3	phosphorylates	phosphorylate	VBZ	VBZ	_	0	root	_	_
4	c-Fos	c-fos	NN	NN	_	3	dobj	_	_
5	at	at	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	site	site	NN	NN	_	4	nmod	_	_
8	near	near	JJ	JJ	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	C-terminus	c-terminus	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	as	as	RB	RB	_	4	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	a	a	DT	DT	_	16	det	_	_
16	peptide	peptide	NN	NN	_	4	conj	_	_
17	derived	derive	VBN	VBN	_	16	acl	_	_
18	from	from	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	region	region	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	residues	residue	NNS	NNS	_	20	dep	_	_
23	359-370	359-370	CD	CD	_	22	nummod	_	_
24	,	,	,	,	_	22	punct	_	_
25	RKGSSSNEPSSD	rkgsssnepssd	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	22	punct	_	_
27	,	,	,	,	_	3	punct	_	_
28	and	and	CC	CC	_	3	cc	_	_
29	Fos	fos	NN	NN	_	30	compound	_	_
30	peptide	peptide	NN	NN	_	32	nsubj	_	_
31	competitively	competitively	RB	RB	_	32	advmod	_	_
32	inhibited	inhibit	VBD	VBD	_	3	conj	_	_
33	c-Fos	c-fos	NN	NN	_	34	compound	_	_
34	phosphorylation	phosphorylation	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	distinct	distinct	JJ	JJ	_	4	xcomp	_	_
8	from	from	IN	IN	_	12	case	_	_
9	other	other	JJ	JJ	_	12	amod	_	_
10	identified	identify	VBN	VBN	_	12	amod	_	_
11	serine/threonine	serine/threonine	NN	NN	_	12	compound	_	_
12	kinases	kinase	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	including	include	VBG	VBG	_	17	case	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	kinase	kinase	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	protein	protein	NN	NN	_	21	compound	_	_
20	kinase	kinase	NN	NN	_	21	compound	_	_
21	C	c	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	casein	casein	NN	NN	_	24	compound	_	_
24	kinase	kinase	NN	NN	_	17	conj	_	_
25	II	ii	CD	CD	_	24	nummod	_	_
26	,	,	,	,	_	17	punct	_	_
27	MAP	map	NN	NN	_	28	compound	_	_
28	kinases	kinase	NNS	NNS	_	17	conj	_	_
29	,	,	,	,	_	17	punct	_	_
30	p70S6K	p70s6k	NN	NN	_	17	conj	_	_
31	and	and	CC	CC	_	17	cc	_	_
32	p90RSK	p90rsk	NN	NN	_	17	conj	_	_
33	.	.	.	.	_	4	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	purified	purify	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	anion	anion	NN	NN	_	8	compound	_	_
7	exchange	exchange	NN	NN	_	8	compound	_	_
8	chromatography	chromatography	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	exhibited	exhibit	VBD	VBD	_	4	conj	_	_
11	an	a	DT	DT	_	13	det	_	_
12	apparent	apparent	JJ	JJ	_	13	amod	_	_
13	M(r)	m(r)	NN	NN	_	10	dobj	_	_
14	=	=	JJ	JJ	_	13	amod	_	_
15	65,000	65,000	CD	CD	_	14	dep	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	isoelectric	isoelectric	JJ	JJ	_	18	amod	_	_
18	point	point	NN	NN	_	13	conj	_	_
19	=	=	JJ	JJ	_	18	amod	_	_
20	6.1	6.1	CD	CD	_	19	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	play	play	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	4	nmod	_	_
10	through	through	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	capacity	capacity	NN	NN	_	4	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	phosphorylate	phosphorylate	VB	VB	_	12	acl	_	_
15	c-Fos	c-fos	NN	NN	_	14	dobj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	site	site	NN	NN	_	14	nmod	_	_
19	required	require	VBN	VBN	_	18	acl	_	_
20	for	for	IN	IN	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
25	transrepressive	transrepressive	JJ	JJ	_	26	amod	_	_
26	activity	activity	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	molecule	molecule	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	rapid	rapid	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	6	nsubj	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	it	it	PRP	PRP	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	have	have	VB	VB	_	6	ccomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	wider	wider	JJR	JJR	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	within	within	IN	IN	_	16	case	_	_
14	signal	signal	NN	NN	_	16	compound	_	_
15	transduction	transduction	NN	NN	_	16	compound	_	_
16	cascades	cascade	NNS	NNS	_	9	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	neuroblastoma	neuroblastoma	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
3	factor	factor	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	14	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	eukaryotic	eukaryotic	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	macrophages	macrophage	NNS	NNS	_	3	conj	_	_
6	it	it	PRP	PRP	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	present	present	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	nuclei	nucleus	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	whereas	whereas	IN	IN	_	23	mark	_	_
15	in	in	IN	IN	_	19	case	_	_
16	many	many	JJ	JJ	_	17	amod	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	types	type	NNS	NNS	_	23	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	23	nsubj	_	_
23	translocates	translocate	VBZ	VBZ	_	9	advcl	_	_
24	from	from	IN	IN	_	25	case	_	_
25	cytosol	cytosol	NN	NN	_	23	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	nucleus	nucleus	NN	NN	_	23	nmod	_	_
28	as	as	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	result	result	NN	NN	_	23	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	transduction	transduction	NN	NN	_	30	nmod	_	_
33	by	by	IN	IN	_	37	case	_	_
34	tumor	tumor	NN	NN	_	37	compound	_	_
35	necrosis	necrosis	NN	NN	_	37	compound	_	_
36	factor	factor	NN	NN	_	37	compound	_	_
37	alpha	alpha	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	TNF	tnf	NN	NN	_	40	compound	_	_
40	alpha	alpha	NN	NN	_	37	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	37	punct	_	_
43	phorbol	phorbol	NN	NN	_	44	compound	_	_
44	ester	ester	NN	NN	_	37	conj	_	_
45	,	,	,	,	_	37	punct	_	_
46	and	and	CC	CC	_	37	cc	_	_
47	other	other	JJ	JJ	_	48	amod	_	_
48	polyclonal	polyclonal	JJ	JJ	_	49	amod	_	_
49	signals	signal	NNS	NNS	_	37	conj	_	_
50	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	neuroblastoma	neuroblastoma	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	1	dobj	_	_
5	as	as	IN	IN	_	6	case	_	_
6	models	model	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	we	we	PRP	PRP	_	10	nsubj	_	_
9	have	have	VBP	VBP	_	10	aux	_	_
10	shown	show	VBN	VBN	_	1	parataxis	_	_
11	that	that	IN	IN	_	18	mark	_	_
12	in	in	IN	IN	_	14	case	_	_
13	neural	neural	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	18	nmod	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	present	present	JJ	JJ	_	10	ccomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytosol	cytosol	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	translocated	translocate	VBD	VBD	_	18	conj	_	_
24	into	into	IN	IN	_	25	case	_	_
25	nuclei	nucleus	NNS	NNS	_	23	nmod	_	_
26	as	as	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	result	result	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	TNF	tnf	NN	NN	_	32	compound	_	_
31	alpha	alpha	NN	NN	_	32	compound	_	_
32	treatment	treatment	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	TNF	tnf	NN	NN	_	5	compound	_	_
3	alpha-activated	alpha-activated	JJ	JJ	_	5	amod	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	transcriptionally	transcriptionally	RB	RB	_	8	advmod	_	_
8	functional	functional	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	9	nsubjpass	_	_
4	by	by	IN	IN	_	6	case	_	_
5	TNF	tnf	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	correlated	correlate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	cell	cell	NN	NN	_	9	nmod	_	_
12	differentiation	differentiation	NN	NN	_	11	dep	_	_
13	or	or	CC	CC	_	11	cc	_	_
14	proliferation	proliferation	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	34	advmod	_	_
2	,	,	,	,	_	34	punct	_	_
3	reagents	reagent	NNS	NNS	_	34	nsubj	_	_
4	such	such	JJ	JJ	_	8	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	nerve	nerve	NN	NN	_	8	compound	_	_
7	growth	growth	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	NGF	ngf	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	18	det	_	_
14	phorbol	phorbol	NN	NN	_	18	compound	_	_
15	ester	ester	NN	NN	_	18	compound	_	_
16	phorbol	phorbol	NN	NN	_	18	compound	_	_
17	12-myristate	12-myristate	NN	NN	_	18	compound	_	_
18	13-acetate	13-acetate	NN	NN	_	8	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PMA	pma	NN	NN	_	8	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	3	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	induce	induce	VBP	VBP	_	3	acl:relcl	_	_
25	phenotypical	phenotypical	JJ	JJ	_	26	amod	_	_
26	differentiation	differentiation	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	SH-SY5Y	sh-sy5y	NN	NN	_	32	compound	_	_
30	neuroblastoma	neuroblastoma	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	line	line	NN	NN	_	26	nmod	_	_
33	,	,	,	,	_	3	punct	_	_
34	activated	activate	VBD	VBD	_	0	root	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	34	dobj	_	_
37	,	,	,	,	_	34	punct	_	_
38	but	but	CC	CC	_	34	cc	_	_
39	only	only	RB	RB	_	44	advmod	_	_
40	in	in	IN	IN	_	44	case	_	_
41	that	that	DT	DT	_	44	det	_	_
42	particular	particular	JJ	JJ	_	44	amod	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	line	line	NN	NN	_	34	conj	_	_
45	.	.	.	.	_	34	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	a	a	DT	DT	_	7	det	_	_
3	NGF-responsive	ngf-responsive	JJ	JJ	_	7	amod	_	_
4	rat	rat	NN	NN	_	7	compound	_	_
5	pheochromocytoma	pheochromocytoma	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	12	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	PC12	pc12	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	12	punct	_	_
11	PMA	pma	NN	NN	_	12	nsubj	_	_
12	activated	activate	VBD	VBD	_	0	root	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	12	punct	_	_
16	whereas	whereas	IN	IN	_	18	mark	_	_
17	NGF	ngf	NN	NN	_	18	nsubj	_	_
18	did	do	VBD	VBD	_	12	advcl	_	_
19	not	not	RB	RB	_	18	neg	_	_
20	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	neuroblastoma	neuroblastoma	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	19	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	such	such	JJ	JJ	_	9	case	_	_
8	as	as	IN	IN	_	7	mwe	_	_
9	SK-N-Be(2)	sk-n-be(2)	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	19	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	lack	lack	NN	NN	_	19	nsubjpass	_	_
13	of	of	IN	IN	_	15	case	_	_
14	PMA	pma	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	differentiation	differentiation	NN	NN	_	15	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	correlated	correlate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	lack	lack	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	moreover	moreover	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	that	that	IN	IN	_	20	mark	_	_
7	in	in	IN	IN	_	9	case	_	_
8	SK-N-Be(2)	sk-n-be(2)	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	20	nmod	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	C	c	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PKC	pkc	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	enzymatic	enzymatic	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	20	nsubj	_	_
18	was	be	VBD	VBD	_	20	cop	_	_
19	much	much	RB	RB	_	20	advmod	_	_
20	lower	lower	JJR	JJR	_	2	ccomp	_	_
21	compared	compare	VBN	VBN	_	20	dep	_	_
22	with	with	IN	IN	_	23	case	_	_
23	that	that	DT	DT	_	21	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	control	control	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	23	nmod	_	_
29	and	and	CC	CC	_	20	cc	_	_
30	that	that	IN	IN	_	37	mark	_	_
31	the	the	DT	DT	_	35	det	_	_
32	low	low	JJ	JJ	_	35	amod	_	_
33	PKC	pkc	NN	NN	_	35	compound	_	_
34	enzymatic	enzymatic	JJ	JJ	_	35	amod	_	_
35	activity	activity	NN	NN	_	37	nsubj	_	_
36	was	be	VBD	VBD	_	37	cop	_	_
37	due	due	JJ	JJ	_	20	conj	_	_
38	to	to	TO	TO	_	42	case	_	_
39	low	low	JJ	JJ	_	42	amod	_	_
40	PKC	pkc	NN	NN	_	42	compound	_	_
41	protein	protein	NN	NN	_	42	compound	_	_
42	expression	expression	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	induced	induce	VBD	VBD	_	8	acl:relcl	_	_
12	morphological	morphological	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	all	all	PDT	PDT	_	19	det:predet	_	_
16	the	the	DT	DT	_	19	det	_	_
17	neuroblastoma	neuroblastoma	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	13	nmod	_	_
20	used	use	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	present	present	JJ	JJ	_	24	amod	_	_
24	study	study	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	12	case	_	_
10	neuroblastoma	neuroblastoma	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	differentiation	differentiation	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	9	nsubj	_	_
5	obtained	obtain	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	8	case	_	_
7	TNF	tnf	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	5	nmod	_	_
9	proved	prove	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	16	nsubj	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	sufficient	sufficient	JJ	JJ	_	9	ccomp	_	_
17	for	for	IN	IN	_	18	case	_	_
18	induction	induction	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	neuroblastoma	neuroblastoma	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Genes	gene	NNS	NNS	_	12	nsubjpass	_	_
2	encoding	encode	VBG	VBG	_	1	acl	_	_
3	general	general	JJ	JJ	_	5	amod	_	_
4	initiation	initiation	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	RNA	rna	NN	NN	_	10	compound	_	_
8	polymerase	polymerase	NN	NN	_	10	compound	_	_
9	II	ii	CD	CD	_	10	nummod	_	_
10	transcription	transcription	NN	NN	_	5	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	dispersed	disperse	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	genome	genome	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	General	general	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	accurate	accurate	JJ	JJ	_	8	amod	_	_
8	initiation	initiation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	RNA	rna	NN	NN	_	13	compound	_	_
13	polymerase	polymerase	NN	NN	_	10	nmod	_	_
14	II	ii	CD	CD	_	13	nummod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	cDNAs	cdna	NNS	NNS	_	10	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	subunits	subunit	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	cloned	clone	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sequenced	sequence	VBN	VBN	_	10	conj	_	_
13	.	.	.	.	_	10	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	fluorescence	fluorescence	NN	NN	_	5	compound	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	situ	situ	FW	FW	_	3	dep	_	_
5	hybridization	hybridization	NN	NN	_	1	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	FISH	fish	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	show	show	VBP	VBP	_	0	root	_	_
12	here	here	RB	RB	_	11	advmod	_	_
13	that	that	IN	IN	_	45	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	genes	gene	NNS	NNS	_	45	nsubj	_	_
16	encoding	encode	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	TATA-box	tata-box	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TBP	tbp	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	20	punct	_	_
25	TFIIB	tfiib	NN	NN	_	20	conj	_	_
26	,	,	,	,	_	20	punct	_	_
27	TFIIE	tfiie	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	20	conj	_	_
29	,	,	,	,	_	20	punct	_	_
30	TFIIE	tfiie	NN	NN	_	31	compound	_	_
31	beta	beta	NN	NN	_	20	conj	_	_
32	,	,	,	,	_	20	punct	_	_
33	RAP30	rap30	NN	NN	_	20	conj	_	_
34	,	,	,	,	_	20	punct	_	_
35	RAP74	rap74	NN	NN	_	20	conj	_	_
36	and	and	CC	CC	_	20	cc	_	_
37	the	the	DT	DT	_	40	det	_	_
38	62	62	CD	CD	_	39	compound	_	_
39	kDa	kda	NN	NN	_	40	amod	_	_
40	subunit	subunit	NN	NN	_	20	conj	_	_
41	,	,	,	,	_	40	punct	_	_
42	of	of	IN	IN	_	43	case	_	_
43	TFIIH	tfiih	NN	NN	_	40	nmod	_	_
44	are	be	VBP	VBP	_	45	cop	_	_
45	located	located	JJ	JJ	_	11	ccomp	_	_
46	at	at	IN	IN	_	50	case	_	_
47	the	the	DT	DT	_	50	det	_	_
48	human	human	JJ	JJ	_	50	amod	_	_
49	chromosomal	chromosomal	JJ	JJ	_	50	amod	_	_
50	bands	band	NNS	NNS	_	45	nmod	_	_
51	6q26-27	6q26-27	NN	NN	_	50	dep	_	_
52	,	,	,	,	_	51	punct	_	_
53	1p21-22	1p21-22	NN	NN	_	51	conj	_	_
54	,	,	,	,	_	51	punct	_	_
55	3q21-24	3q21-24	NN	NN	_	51	conj	_	_
56	,	,	,	,	_	51	punct	_	_
57	8p12	8p12	NN	NN	_	51	conj	_	_
58	,	,	,	,	_	51	punct	_	_
59	13q14	13q14	NN	NN	_	51	conj	_	_
60	,	,	,	,	_	51	punct	_	_
61	19p13.3	19p13.3	NN	NN	_	51	conj	_	_
62	and	and	CC	CC	_	51	cc	_	_
63	11p14-15.1	11p14-15.1	NN	NN	_	51	conj	_	_
64	,	,	,	,	_	50	punct	_	_
65	respectively	respectively	RB	RB	_	50	advmod	_	_
66	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	dispersed	dispersed	JJ	JJ	_	3	amod	_	_
3	localization	localization	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	group	group	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	functionally	functionally	RB	RB	_	9	advmod	_	_
9	related	related	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	provides	provide	VBZ	VBZ	_	0	root	_	_
12	insights	insight	NNS	NNS	_	11	dobj	_	_
13	into	into	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	mechanism	mechanism	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	genome	genome	NN	NN	_	20	compound	_	_
20	evolution	evolution	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
23	possible	possible	JJ	JJ	_	24	amod	_	_
24	involvement	involvement	NN	NN	_	16	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	human	human	JJ	JJ	_	27	amod	_	_
27	diseases	disease	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	heterodimerization	heterodimerization	NN	NN	_	4	compound	_	_
4	partner	partner	NN	NN	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	thyroid	thyroid	NN	NN	_	8	compound	_	_
7	hormone	hormone	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Peroxisome	peroxisome	NN	NN	_	3	compound	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	3	amod	_	_
3	receptor	receptor	NN	NN	_	0	root	_	_
4	.	.	.	.	_	3	punct	_	_

1	Retinoid-like	retinoid-like	JJ	JJ	_	2	amod	_	_
2	receptors	receptor	NNS	NNS	_	3	nsubj	_	_
3	play	play	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	central	central	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	hormonal	hormonal	JJ	JJ	_	9	amod	_	_
9	responses	response	NNS	NNS	_	3	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	forming	form	VBG	VBG	_	3	advcl	_	_
12	heterodimers	heterodimer	NNS	NNS	_	11	dobj	_	_
13	with	with	IN	IN	_	17	case	_	_
14	other	other	JJ	JJ	_	17	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	hormone	hormone	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	peroxisome	peroxisome	NN	NN	_	10	compound	_	_
9	proliferator-activated	proliferator-activated	JJ	JJ	_	10	amod	_	_
10	receptor	receptor	NN	NN	_	6	dobj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PPAR	ppar	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	as	as	IN	IN	_	25	case	_	_
15	a	a	DT	DT	_	25	det	_	_
16	new	new	JJ	JJ	_	25	amod	_	_
17	thyroid	thyroid	NN	NN	_	25	compound	_	_
18	hormone	hormone	NN	NN	_	25	compound	_	_
19	receptor	receptor	NN	NN	_	25	compound	_	_
20	(	(	-LRB-	-LRB-	_	25	punct	_	_
21	THR	thr	NN	NN	_	25	compound	_	_
22	)	)	-RRB-	-RRB-	_	25	punct	_	_
23	auxiliary	auxiliary	JJ	JJ	_	25	amod	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	6	nmod	_	_
26	,	,	,	,	_	6	punct	_	_
27	heterodimerizing	heterodimerize	VBG	VBG	_	6	advcl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	THR	thr	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	solution	solution	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	heterodimers	heterodimer	NNS	NNS	_	6	nsubj	_	_
4	do	do	VBP	VBP	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	recognize	recognize	VB	VB	_	29	advcl	_	_
7	a	a	DT	DT	_	12	det	_	_
8	classical	classical	JJ	JJ	_	12	amod	_	_
9	thyroid	thyroid	NN	NN	_	12	compound	_	_
10	hormone	hormone	NN	NN	_	12	compound	_	_
11	response	response	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	6	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	TRE	tre	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	characterized	characterize	VBN	VBN	_	12	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	direct	direct	JJ	JJ	_	19	amod	_	_
19	repeat	repeat	NN	NN	_	16	nmod	_	_
20	separated	separate	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	four	four	CD	CD	_	23	nummod	_	_
23	nucleotides	nucleotide	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	DR+4	dr+4	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	29	punct	_	_
28	PPAR	ppar	NN	NN	_	29	nsubj	_	_
29	behaves	behave	VBZ	VBZ	_	0	root	_	_
30	as	as	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	dominant	dominant	JJ	JJ	_	34	amod	_	_
33	negative	negative	JJ	JJ	_	34	amod	_	_
34	regulator	regulator	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	41	case	_	_
36	thyroid	thyroid	NN	NN	_	37	compound	_	_
37	hormone	hormone	NN	NN	_	41	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	TH	th	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	action	action	NN	NN	_	34	nmod	_	_
42	.	.	.	.	_	29	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	TH-dependent	th-dependent	JJ	JJ	_	6	amod	_	_
5	positive	positive	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	elicited	elicit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	selective	selective	JJ	JJ	_	11	amod	_	_
11	interaction	interaction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	THR	thr	NN	NN	_	15	compound	_	_
15	beta-PPAR	beta-ppar	NN	NN	_	11	nmod	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	15	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	THR	thr	NN	NN	_	21	compound	_	_
20	alpha-PPAR	alpha-ppar	NN	NN	_	21	compound	_	_
21	heterodimer	heterodimer	NN	NN	_	15	conj	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	novel	novel	JJ	JJ	_	25	amod	_	_
25	TRE	tre	NN	NN	_	11	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	DR+2	dr+2	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	critical	critical	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	THR	thr	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	mapped	map	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	3	3	CD	CD	_	12	nummod	_	_
11	amino	amino	NN	NN	_	12	compound	_	_
12	acids	acid	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	distal	distal	JJ	JJ	_	16	amod	_	_
16	box	box	NN	NN	_	8	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	DNA	dna	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	domain	domain	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Hence	hence	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	PPAR	ppar	NN	NN	_	8	nsubj	_	_
4	can	can	MD	MD	_	8	aux	_	_
5	positively	positively	RB	RB	_	6	advmod	_	_
6	or	or	CC	CC	_	8	advmod	_	_
7	negatively	negatively	RB	RB	_	6	advmod	_	_
8	influence	influence	VB	VB	_	0	root	_	_
9	TH	th	NN	NN	_	10	compound	_	_
10	action	action	NN	NN	_	8	dobj	_	_
11	depending	depend	VBG	VBG	_	14	case	_	_
12	on	on	IN	IN	_	14	case	_	_
13	TRE	tre	NN	NN	_	14	compound	_	_
14	structure	structure	NN	NN	_	8	advcl	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	THR	thr	NN	NN	_	17	compound	_	_
17	isotype	isotype	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	8	punct	_	_

1	Hypoxic	hypoxic	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	interleukin-8	interleukin-8	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	8	mark	_	_
2	leukocyte-mediated	leukocyte-mediated	JJ	JJ	_	4	amod	_	_
3	tissue	tissue	NN	NN	_	4	compound	_	_
4	damage	damage	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	component	component	NN	NN	_	18	advcl	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	pathologic	pathologic	JJ	JJ	_	12	amod	_	_
12	picture	picture	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	ischemia/reperfusion	ischemia/reperfusion	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	sought	seek	VBN	VBN	_	0	root	_	_
19	mechanisms	mechanism	NNS	NNS	_	18	dobj	_	_
20	by	by	IN	IN	_	21	case	_	_
21	which	which	WDT	WDT	_	24	nmod	_	_
22	PMNs	pmn	NNS	NNS	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	directed	direct	VBN	VBN	_	19	acl:relcl	_	_
25	into	into	IN	IN	_	27	case	_	_
26	hypoxic	hypoxic	JJ	JJ	_	27	amod	_	_
27	tissue	tissue	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	Incubation	incubation	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ECs	ec	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	10	case	_	_
10	hypoxia	hypoxia	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	PO2	po2	NN	NN	_	10	appos	_	_
13	approximately	approximately	RB	RB	_	14	advmod	_	_
14	14-18	14-18	CD	CD	_	15	nummod	_	_
15	Torr	torr	NN	NN	_	12	dep	_	_
16	,	,	,	,	_	10	punct	_	_
17	led	lead	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	time-dependent	time-dependent	JJ	JJ	_	20	amod	_	_
20	release	release	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	IL-8	il-8	NN	NN	_	23	compound	_	_
23	antigen	antigen	NN	NN	_	20	nmod	_	_
24	into	into	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	conditioned	conditioned	JJ	JJ	_	27	amod	_	_
27	medium	medium	NN	NN	_	20	nmod	_	_
28	;	;	:	:	_	17	punct	_	_
29	this	this	DT	DT	_	31	nsubjpass	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	accompanied	accompany	VBN	VBN	_	17	parataxis	_	_
32	by	by	IN	IN	_	35	case	_	_
33	increased	increase	VBN	VBN	_	35	amod	_	_
34	chemotactic	chemotactic	JJ	JJ	_	35	amod	_	_
35	activity	activity	NN	NN	_	31	nmod	_	_
36	for	for	IN	IN	_	37	case	_	_
37	PMNs	pmn	NNS	NNS	_	35	nmod	_	_
38	,	,	,	,	_	35	punct	_	_
39	blocked	block	VBN	VBN	_	35	acl	_	_
40	by	by	IN	IN	_	41	case	_	_
41	antibody	antibody	NN	NN	_	39	nmod	_	_
42	to	to	TO	TO	_	43	case	_	_
43	IL-8	il-8	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	17	punct	_	_

1	Production	production	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-8	il-8	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	hypoxic	hypoxic	JJ	JJ	_	6	amod	_	_
6	ECs	ec	NNS	NNS	_	1	nmod	_	_
7	occurred	occur	VBD	VBD	_	0	root	_	_
8	concomitantly	concomitantly	RB	RB	_	7	advmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	both	both	DT	DT	_	12	cc:preconj	_	_
11	increased	increase	VBN	VBN	_	12	amod	_	_
12	levels	level	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IL-8	il-8	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	based	base	VBN	VBN	_	22	case	_	_
18	on	on	IN	IN	_	22	case	_	_
19	polymerase	polymerase	NN	NN	_	22	compound	_	_
20	chain	chain	NN	NN	_	22	compound	_	_
21	reaction	reaction	NN	NN	_	22	compound	_	_
22	analysis	analysis	NN	NN	_	12	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	and	and	CC	CC	_	12	cc	_	_
25	increased	increase	VBN	VBN	_	27	amod	_	_
26	IL-8	il-8	NN	NN	_	27	compound	_	_
27	transcription	transcription	NN	NN	_	12	conj	_	_
28	,	,	,	,	_	27	punct	_	_
29	based	base	VBN	VBN	_	33	case	_	_
30	on	on	IN	IN	_	33	case	_	_
31	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
32	run-on	run-on	JJ	JJ	_	33	amod	_	_
33	assays	assay	NNS	NNS	_	27	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Northern	northern	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	mRNA	mrna	NN	NN	_	2	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	hypoxic	hypoxic	JJ	JJ	_	7	amod	_	_
7	ECs	ec	NNS	NNS	_	4	nmod	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	levels	level	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	mRNA	mrna	NN	NN	_	11	nmod	_	_
14	for	for	IN	IN	_	17	case	_	_
15	macrophage	macrophage	NN	NN	_	17	compound	_	_
16	chemotactic	chemotactic	NN	NN	_	17	compound	_	_
17	protein-1	protein-1	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	another	another	DT	DT	_	20	det	_	_
20	member	member	NN	NN	_	17	appos	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	chemokine	chemokine	NN	NN	_	24	compound	_	_
24	superfamily	superfamily	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	proinflammatory	proinflammatory	JJ	JJ	_	27	amod	_	_
27	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	IL-8	il-8	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	8	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	hypoxic	hypoxic	JJ	JJ	_	18	amod	_	_
18	ECs	ec	NNS	NNS	_	15	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	NF-kB	nf-kb	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Studies	study	NNS	NNS	_	11	nsubj	_	_
2	with	with	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	umbilical	umbilical	JJ	JJ	_	6	amod	_	_
5	vein	vein	NN	NN	_	6	compound	_	_
6	segments	segment	NNS	NNS	_	1	nmod	_	_
7	exposed	expose	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	9	case	_	_
9	hypoxia	hypoxia	NN	NN	_	7	nmod	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	elaboration	elaboration	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	IL-8	il-8	NN	NN	_	16	compound	_	_
16	antigen	antigen	NN	NN	_	13	nmod	_	_
17	compared	compare	VBN	VBN	_	20	case	_	_
18	with	with	IN	IN	_	20	case	_	_
19	normoxic	normoxic	JJ	JJ	_	20	amod	_	_
20	controls	control	NNS	NNS	_	11	advcl	_	_
21	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	mice	mouse	NNS	NNS	_	14	nmod	_	_
3	exposed	expose	VBN	VBN	_	2	acl	_	_
4	to	to	TO	TO	_	5	case	_	_
5	hypoxia	hypoxia	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PO2	po2	NN	NN	_	5	dep	_	_
8	approximately	approximately	RB	RB	_	9	advmod	_	_
9	30-40	30-40	CD	CD	_	10	nummod	_	_
10	Torr	torr	NN	NN	_	7	dep	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	,	,	,	,	_	14	punct	_	_
13	there	there	EX	EX	_	14	expl	_	_
14	was	be	VBD	VBD	_	0	root	_	_
15	increased	increase	VBN	VBN	_	17	amod	_	_
16	pulmonary	pulmonary	JJ	JJ	_	17	amod	_	_
17	leukostasis	leukostasis	NN	NN	_	14	nsubj	_	_
18	,	,	,	,	_	14	punct	_	_
19	as	as	IN	IN	_	20	dep	_	_
20	evidenced	evidence	VBN	VBN	_	14	dep	_	_
21	by	by	IN	IN	_	24	case	_	_
22	increased	increase	VBN	VBN	_	24	amod	_	_
23	myeloperoxidase	myeloperoxidase	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	tissue	tissue	NN	NN	_	27	compound	_	_
27	homogenates	homogenate	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	levels	level	NNS	NNS	_	23	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	transcripts	transcript	NNS	NNS	_	5	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	IP-10	ip-10	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	murine	murine	NN	NN	_	13	compound	_	_
13	homologue	homologue	NN	NN	_	9	appos	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	chemokine	chemokine	NN	NN	_	17	compound	_	_
17	family	family	NN	NN	_	13	nmod	_	_
18	related	related	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	IL-8	il-8	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	observed	observe	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	27	case	_	_
25	hypoxic	hypoxic	JJ	JJ	_	27	amod	_	_
26	lung	lung	NN	NN	_	27	compound	_	_
27	tissue	tissue	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	Taken	take	VBN	VBN	_	6	dep	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	hypoxia	hypoxia	NN	NN	_	9	nsubj	_	_
9	constitutes	constitute	VBZ	VBZ	_	6	ccomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	stimulus	stimulus	NN	NN	_	9	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	leukocyte	leukocyte	NN	NN	_	14	compound	_	_
14	chemotaxis	chemotaxis	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	tissue	tissue	NN	NN	_	17	compound	_	_
17	leukostasis	leukostasis	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Function	function	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
4	B/Rel	b/rel	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	sites	site	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	16	case	_	_
8	the	the	DT	DT	_	16	det	_	_
9	major	major	JJ	JJ	_	16	amod	_	_
10	histocompatibility	histocompatibility	NN	NN	_	16	compound	_	_
11	complex	complex	NN	NN	_	16	compound	_	_
12	class	class	NN	NN	_	16	compound	_	_
13	II	ii	CD	CD	_	16	nummod	_	_
14	invariant	invariant	JJ	JJ	_	16	amod	_	_
15	chain	chain	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	1	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	dependent	dependent	JJ	JJ	_	0	root	_	_
19	on	on	IN	IN	_	21	case	_	_
20	cell-specific	cell-specific	JJ	JJ	_	21	amod	_	_
21	binding	binding	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	different	different	JJ	JJ	_	26	amod	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B/Rel	b/rel	NN	NN	_	26	compound	_	_
26	subunits	subunit	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoter	promoter	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	12	case	_	_
4	the	the	DT	DT	_	12	det	_	_
5	human	human	JJ	JJ	_	12	amod	_	_
6	major	major	JJ	JJ	_	12	amod	_	_
7	histocompatibility	histocompatibility	NN	NN	_	12	compound	_	_
8	complex	complex	NN	NN	_	12	compound	_	_
9	class	class	NN	NN	_	12	compound	_	_
10	II-associated	ii-associated	JJ	JJ	_	12	amod	_	_
11	invariant-chain	invariant-chain	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	2	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	Ii	ii	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	contains	contain	VBZ	VBZ	_	0	root	_	_
17	two	two	CD	CD	_	21	nummod	_	_
18	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
19	B/Rel	b/rel	NN	NN	_	21	compound	_	_
20	binding	bind	VBG	VBG	_	21	amod	_	_
21	sites	site	NNS	NNS	_	16	dobj	_	_
22	located	located	JJ	JJ	_	21	amod	_	_
23	at	at	IN	IN	_	26	case	_	_
24	-109	-109	CD	CD	_	26	nummod	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	-118	-118	CD	CD	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	Ii	ii	NN	NN	_	30	compound	_	_
29	kappa	kappa	NN	NN	_	30	compound	_	_
30	B-1	b-1	NN	NN	_	26	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	26	cc	_	_
33	-163	-163	CD	CD	_	35	nummod	_	_
34	to	to	TO	TO	_	35	dep	_	_
35	-172	-172	CD	CD	_	26	conj	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	Ii	ii	NN	NN	_	39	compound	_	_
38	kappa	kappa	NN	NN	_	39	compound	_	_
39	B-2	b-2	NN	NN	_	35	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	from	from	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	transcription	transcription	NN	NN	_	45	compound	_	_
44	start	start	NN	NN	_	45	compound	_	_
45	site	site	NN	NN	_	26	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	function	function	NN	NN	_	20	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	each	each	DT	DT	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	these	these	DT	DT	_	14	det	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B/Rel	b/rel	NN	NN	_	14	compound	_	_
14	sites	site	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	several	several	JJ	JJ	_	17	amod	_	_
17	distinct	distinct	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	types	type	NNS	NNS	_	14	nmod	_	_
20	depends	depend	VBZ	VBZ	_	2	ccomp	_	_
21	on	on	IN	IN	_	23	case	_	_
22	cell-specific	cell-specific	JJ	JJ	_	23	amod	_	_
23	binding	binding	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
26	B/Rel	b/rel	NN	NN	_	28	compound	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Ii	ii	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B-1	b-1	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	positive	positive	JJ	JJ	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	element	element	NN	NN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	Ii-expressing	ii-expressing	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	17	punct	_	_
19	H9	h9	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	17	punct	_	_
21	but	but	CC	CC	_	8	cc	_	_
22	acts	act	VBZ	VBZ	_	8	conj	_	_
23	as	as	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	negative	negative	JJ	JJ	_	27	amod	_	_
26	regulatory	regulatory	JJ	JJ	_	27	amod	_	_
27	element	element	NN	NN	_	22	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	myelomonocytic	myelomonocytic	JJ	JJ	_	22	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	glia	glia	NN	NN	_	29	conj	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	29	dep	_	_
34	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
4	contacts	contact	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	detectable	detectable	JJ	JJ	_	0	root	_	_
7	at	at	IN	IN	_	10	case	_	_
8	Ii	ii	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B-1	b-1	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	19	nmod	_	_
16	this	this	DT	DT	_	17	det	_	_
17	site	site	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	functional	functional	JJ	JJ	_	13	acl:relcl	_	_
20	as	as	IN	IN	_	23	case	_	_
21	either	either	CC	CC	_	23	cc:preconj	_	_
22	a	a	DT	DT	_	23	dep	_	_
23	positive	positive	JJ	JJ	_	19	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	negative	negative	JJ	JJ	_	23	conj	_	_
26	regulator	regulator	NN	NN	_	23	dep	_	_
27	.	.	.	.	_	6	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	supershift	supershift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	determine	determine	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	members	member	NNS	NNS	_	17	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B/Rel	b/rel	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	12	nmod	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	bind	bind	VB	VB	_	5	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	site	site	NN	NN	_	17	nmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vitro	vitro	FW	FW	_	17	advmod	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	that	that	IN	IN	_	37	mark	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	complexes	complex	NNS	NNS	_	37	nsubj	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	contain	contain	VBP	VBP	_	26	acl:relcl	_	_
29	p50	p50	NN	NN	_	28	dobj	_	_
30	,	,	,	,	_	29	punct	_	_
31	p52	p52	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	p65	p65	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	cRel	crel	NN	NN	_	29	conj	_	_
37	correlate	correlate	VBP	VBP	_	17	conj	_	_
38	with	with	IN	IN	_	40	case	_	_
39	positive	positive	JJ	JJ	_	40	amod	_	_
40	regulation	regulation	NN	NN	_	37	nmod	_	_
41	whereas	whereas	IN	IN	_	46	mark	_	_
42	the	the	DT	DT	_	43	det	_	_
43	presence	presence	NN	NN	_	46	nsubj	_	_
44	of	of	IN	IN	_	45	case	_	_
45	p50	p50	NN	NN	_	43	nmod	_	_
46	correlates	correlate	VBZ	VBZ	_	37	advcl	_	_
47	with	with	IN	IN	_	49	case	_	_
48	negative	negative	JJ	JJ	_	49	amod	_	_
49	regulation	regulation	NN	NN	_	46	nmod	_	_
50	.	.	.	.	_	5	punct	_	_

1	Ii	ii	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B-2	b-2	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	site	site	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	positive	positive	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	a	a	DT	DT	_	15	det	_	_
15	site	site	NN	NN	_	6	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	negative	negative	JJ	JJ	_	18	amod	_	_
18	regulation	regulation	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	H9	h9	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	myelomonocytic	myelomonocytic	JJ	JJ	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	glial	glial	JJ	JJ	_	22	conj	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	22	dep	_	_
30	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	occupancy	occupancy	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	site	site	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	only	only	RB	RB	_	14	advmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	H9	h9	NN	NN	_	14	compound	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Again	again	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	supershift	supershift	NN	NN	_	6	compound	_	_
6	studies	study	NNS	NNS	_	7	nsubj	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	20	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	20	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	p50	p50	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	p52	p52	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	p65	p65	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	cRel	crel	NN	NN	_	12	conj	_	_
20	correlates	correlate	VBZ	VBZ	_	7	ccomp	_	_
21	with	with	IN	IN	_	23	case	_	_
22	positive	positive	JJ	JJ	_	23	amod	_	_
23	function	function	NN	NN	_	20	nmod	_	_
24	whereas	whereas	IN	IN	_	32	mark	_	_
25	the	the	DT	DT	_	26	det	_	_
26	presence	presence	NN	NN	_	32	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	only	only	JJ	JJ	_	29	advmod	_	_
29	p50	p50	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	p52	p52	NN	NN	_	29	conj	_	_
32	correlates	correlate	VBZ	VBZ	_	20	advcl	_	_
33	with	with	IN	IN	_	35	case	_	_
34	negative	negative	JJ	JJ	_	35	amod	_	_
35	function	function	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	differential	differential	JJ	JJ	_	3	amod	_	_
3	binding	binding	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	specific	specific	JJ	JJ	_	8	amod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B/Rel	b/rel	NN	NN	_	8	compound	_	_
8	subunits	subunit	NNS	NNS	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	likely	likely	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	mediate	mediate	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	disparate	disparate	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	12	dobj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	these	these	DT	DT	_	22	det	_	_
18	two	two	CD	CD	_	22	nummod	_	_
19	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
20	B/Rel	b/rel	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	Positive	positive	JJ	JJ	_	2	amod	_	_
2	regulators	regulator	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	lineage-specific	lineage-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	GATA-1	gata-1	NN	NN	_	7	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	differentiating	differentiating	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	zinc	zinc	NN	NN	_	5	compound	_	_
3	finger	finger	NN	NN	_	5	compound	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	10	nsubj	_	_
6	GATA-1	gata-1	NN	NN	_	5	dep	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	major	major	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	13	case	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	erythroid	erythroid	JJ	JJ	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	megakaryocyte	megakaryocyte	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	mast	mast	NN	NN	_	15	conj	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lineages	lineage	NNS	NNS	_	15	dep	_	_
23	.	.	.	.	_	10	punct	_	_

1	GATA-1	gata-1	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	WGATAR	wgatar	NN	NN	_	6	compound	_	_
5	consensus	consensus	NN	NN	_	6	compound	_	_
6	motifs	motif	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	regions	region	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	virtually	virtually	RB	RB	_	16	advmod	_	_
13	all	all	DT	DT	_	16	det	_	_
14	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
15	cell-specific	cell-specific	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Analyses	analysis	NNS	NNS	_	9	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	cultured	culture	VBN	VBN	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cell-free	cell-free	JJ	JJ	_	7	amod	_	_
7	systems	system	NNS	NNS	_	4	conj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	provided	provide	VBN	VBN	_	0	root	_	_
10	strong	strong	JJ	JJ	_	11	amod	_	_
11	evidence	evidence	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	GATA-1	gata-1	NN	NN	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	11	ccomp	_	_
16	in	in	IN	IN	_	17	case	_	_
17	control	control	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	globin	globin	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	during	during	IN	IN	_	24	case	_	_
23	erythroid	erythroid	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Targeted	target	VBN	VBN	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	GATA-1	gata-1	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	embryonic	embryonic	JJ	JJ	_	10	amod	_	_
9	stem	stem	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	has	have	VBZ	VBZ	_	12	aux	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	requirement	requirement	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	development	development	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Efficient	efficient	JJ	JJ	_	2	amod	_	_
2	rescue	rescue	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	defect	defect	NN	NN	_	2	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	10	det	_	_
8	intact	intact	JJ	JJ	_	10	amod	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	distal	distal	JJ	JJ	_	14	amod	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
17	autoregulatory	autoregulatory	JJ	JJ	_	18	amod	_	_
18	control	control	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	GATA-1	gata-1	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	GATA-1	gata-1	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	6	nsubj	_	_
6	involves	involve	VBZ	VBZ	_	2	ccomp	_	_
7	additional	additional	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	6	dobj	_	_
10	or	or	CC	CC	_	6	cc	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	maintained	maintain	VBN	VBN	_	6	conj	_	_
13	entirely	entirely	RB	RB	_	12	advmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	autoregulatory	autoregulatory	JJ	JJ	_	17	amod	_	_
17	loop	loop	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	we	we	PRP	PRP	_	21	nsubj	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	used	use	VBN	VBN	_	2	parataxis	_	_
22	a	a	DT	DT	_	25	det	_	_
23	transient	transient	JJ	JJ	_	25	amod	_	_
24	heterokaryon	heterokaryon	NN	NN	_	25	compound	_	_
25	system	system	NN	NN	_	21	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	test	test	VB	VB	_	21	xcomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	ability	ability	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	erythroid	erythroid	JJ	JJ	_	32	amod	_	_
32	factors	factor	NNS	NNS	_	29	nmod	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	activate	activate	VB	VB	_	29	acl	_	_
35	the	the	DT	DT	_	37	det	_	_
36	GATA-1	gata-1	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	34	dobj	_	_
38	in	in	IN	IN	_	40	case	_	_
39	nonerythroid	nonerythroid	JJ	JJ	_	40	amod	_	_
40	nuclei	nucleus	NNS	NNS	_	34	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	proerythroblasts	proerythroblast	NNS	NNS	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	mature	mature	JJ	JJ	_	9	amod	_	_
8	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	conj	_	_
10	contain	contain	VBP	VBP	_	2	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	diffusible	diffusible	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TAG	tag	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	capable	capable	JJ	JJ	_	13	amod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	GATA-1	gata-1	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	that	that	IN	IN	_	27	mark	_	_
25	this	this	DT	DT	_	26	det	_	_
26	activity	activity	NN	NN	_	27	nsubj	_	_
27	decreases	decrease	VBZ	VBZ	_	10	conj	_	_
28	during	during	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	terminal	terminal	JJ	JJ	_	31	amod	_	_
31	differentiation	differentiation	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	erythroid	erythroid	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	Nuclei	nucleus	NNS	NNS	_	10	nsubjpass	_	_
2	from	from	IN	IN	_	6	case	_	_
3	GATA-1-mutant	gata-1-mutant	JJ	JJ	_	6	amod	_	_
4	embryonic	embryonic	JJ	JJ	_	6	amod	_	_
5	stem	stem	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	can	can	MD	MD	_	10	aux	_	_
8	still	still	RB	RB	_	10	advmod	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	reprogrammed	reprogram	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	express	express	VB	VB	_	10	dep	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	globin	globin	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	heterokaryons	heterokaryon	NNS	NNS	_	12	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	indicating	indicate	VBG	VBG	_	10	xcomp	_	_
21	that	that	IN	IN	_	29	mark	_	_
22	de	de	FW	FW	_	24	amod	_	_
23	novo	novo	FW	FW	_	22	dep	_	_
24	induction	induction	NN	NN	_	29	nsubjpass	_	_
25	of	of	IN	IN	_	26	case	_	_
26	GATA-1	gata-1	NN	NN	_	24	nmod	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	required	require	VBN	VBN	_	20	ccomp	_	_
30	for	for	IN	IN	_	33	case	_	_
31	globin	globin	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	29	nmod	_	_
34	following	follow	VBG	VBG	_	36	case	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	fusion	fusion	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	ERP	erp	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	member	member	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	ets	ets	NN	NN	_	11	compound	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor/oncoprotein	factor/oncoprotein	NN	NN	_	11	compound	_	_
11	family	family	NN	NN	_	5	nmod	_	_
12	:	:	:	:	_	1	punct	_	_
13	cloning	clone	VBG	VBG	_	1	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	characterization	characterization	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	differential	differential	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	13	conj	_	_
20	during	during	IN	IN	_	22	case	_	_
21	B-lymphocyte	b-lymphocyte	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ets	ets	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	family	family	NN	NN	_	5	nsubj	_	_
5	encodes	encode	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	group	group	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	proteins	protein	NNS	NNS	_	7	nmod	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	function	function	VBP	VBP	_	9	acl:relcl	_	_
12	as	as	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	under	under	IN	IN	_	17	case	_	_
16	physiological	physiological	JJ	JJ	_	17	amod	_	_
17	conditions	condition	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	,	,	,	,	_	11	punct	_	_
20	if	if	IN	IN	_	22	dep	_	_
21	aberrantly	aberrantly	RB	RB	_	22	advmod	_	_
22	expressed	express	VBN	VBN	_	11	advcl	_	_
23	,	,	,	,	_	11	punct	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	cause	cause	VB	VB	_	11	dep	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	transformation	transformation	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	4	dobj	_	_
8	in	in	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	det	_	_
10	murine	murine	NN	NN	_	16	compound	_	_
11	immunoglobulin	immunoglobulin	NN	NN	_	16	compound	_	_
12	heavy-chain	heavy-chain	JJ	JJ	_	16	amod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	IgH	igh	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	enhancer	enhancer	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	pi	pi	NN	NN	_	7	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	microB	microb	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	7	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	exhibit	exhibit	VBP	VBP	_	7	acl:relcl	_	_
24	striking	striking	JJ	JJ	_	25	amod	_	_
25	similarity	similarity	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	binding	bind	VBG	VBG	_	28	amod	_	_
28	sites	site	NNS	NNS	_	25	nmod	_	_
29	for	for	IN	IN	_	31	case	_	_
30	ets-related	ets-related	JJ	JJ	_	31	amod	_	_
31	proteins	protein	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	ets-related	ets-related	JJ	JJ	_	5	amod	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	regulators	regulator	NNS	NNS	_	2	dobj	_	_
6	expressed	express	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	pre-B	pre-b	JJ	JJ	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	interact	interact	VB	VB	_	9	acl:relcl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	either	either	CC	CC	_	16	cc:preconj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pi	pi	NN	NN	_	12	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	microB	microb	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	2	punct	_	_
22	we	we	PRP	PRP	_	24	nsubj	_	_
23	have	have	VBP	VBP	_	24	aux	_	_
24	used	use	VBN	VBN	_	2	parataxis	_	_
25	a	a	DT	DT	_	27	det	_	_
26	PCR	pcr	NN	NN	_	27	compound	_	_
27	approach	approach	NN	NN	_	24	dobj	_	_
28	with	with	IN	IN	_	30	case	_	_
29	degenerate	degenerate	JJ	JJ	_	30	amod	_	_
30	oligonucleotides	oligonucleotide	NNS	NNS	_	27	nmod	_	_
31	encoding	encode	VBG	VBG	_	30	acl	_	_
32	conserved	conserve	VBN	VBN	_	33	amod	_	_
33	sequences	sequence	NNS	NNS	_	31	dobj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	all	all	DT	DT	_	36	det	_	_
36	members	member	NNS	NNS	_	31	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	ets	ets	NN	NN	_	40	compound	_	_
40	family	family	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	gene	gene	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	new	new	JJ	JJ	_	11	amod	_	_
9	ets-related	ets-related	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	ERP	erp	NN	NN	_	11	appos	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	ets-related	ets-related	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	3	punct	_	_
19	from	from	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	murine	murine	NN	NN	_	24	compound	_	_
22	pre-B	pre-b	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	3	nmod	_	_
25	BASC	basc	NN	NN	_	26	compound	_	_
26	6C2	6c2	NN	NN	_	24	dep	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	from	from	IN	IN	_	31	case	_	_
29	mouse	mouse	NN	NN	_	31	compound	_	_
30	lung	lung	NN	NN	_	31	compound	_	_
31	tissue	tissue	NN	NN	_	24	conj	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ERP	erp	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	region	region	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	homology	homology	NN	NN	_	6	nmod	_	_
10	with	with	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	ETS	ets	NN	NN	_	14	compound	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	9	nmod	_	_
15	common	common	JJ	JJ	_	14	amod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	all	all	DT	DT	_	18	det	_	_
18	members	member	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	ets	ets	NN	NN	_	24	compound	_	_
22	transcription	transcription	NN	NN	_	24	compound	_	_
23	factor/oncoprotein	factor/oncoprotein	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Three	three	CD	CD	_	4	nummod	_	_
2	additional	additional	JJ	JJ	_	4	amod	_	_
3	smaller	smaller	JJR	JJR	_	2	dep	_	_
4	regions	region	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	homology	homology	NN	NN	_	5	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	ELK-1	elk-1	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	SAP-1	sap-1	NN	NN	_	9	conj	_	_
12	genes	gene	NNS	NNS	_	9	dep	_	_
13	,	,	,	,	_	9	punct	_	_
14	a	a	DT	DT	_	15	det	_	_
15	subgroup	subgroup	NN	NN	_	9	appos	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	ets	ets	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	15	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	interacts	interact	VBZ	VBZ	_	20	acl:relcl	_	_
23	with	with	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	serum	serum	NN	NN	_	27	compound	_	_
26	response	response	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Full-length	full-length	JJ	JJ	_	2	amod	_	_
2	ERP	erp	NN	NN	_	3	nsubj	_	_
3	expresses	express	VBZ	VBZ	_	0	root	_	_
4	only	only	RB	RB	_	7	advmod	_	_
5	negligible	negligible	JJ	JJ	_	7	amod	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	by	by	IN	IN	_	9	case	_	_
9	itself	itself	PRP	PRP	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Removal	removal	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	carboxy	carboxy	NN	NN	_	5	compound	_	_
5	terminus	terminus	NN	NN	_	1	nmod	_	_
6	enables	enable	VBZ	VBZ	_	0	root	_	_
7	ERP	erp	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	interact	interact	VB	VB	_	6	xcomp	_	_
10	with	with	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	variety	variety	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	ets-binding	ets-binding	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	12	nmod	_	_
16	including	include	VBG	VBG	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	E74	e74	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	the	the	DT	DT	_	25	det	_	_
22	IgH	igh	NN	NN	_	25	compound	_	_
23	enhancer	enhancer	NN	NN	_	25	compound	_	_
24	pi	pi	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	the	the	DT	DT	_	32	det	_	_
29	lck	lck	NN	NN	_	32	compound	_	_
30	promoter	promoter	NN	NN	_	32	compound	_	_
31	ets	ets	NN	NN	_	32	compound	_	_
32	site	site	NN	NN	_	19	conj	_	_
33	,	,	,	,	_	6	punct	_	_
34	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
35	a	a	DT	DT	_	39	det	_	_
36	carboxy-terminal	carboxy-terminal	JJ	JJ	_	39	amod	_	_
37	negative	negative	JJ	JJ	_	39	amod	_	_
38	regulatory	regulatory	JJ	JJ	_	39	amod	_	_
39	domain	domain	NN	NN	_	34	dobj	_	_
40	.	.	.	.	_	6	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	nmod:npmod	_	_
3	three	three	CD	CD	_	5	nummod	_	_
4	ERP-related	erp-related	JJ	JJ	_	5	amod	_	_
5	transcripts	transcript	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	tissues	tissue	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	within	within	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	B-cell	b-cell	NN	NN	_	6	compound	_	_
6	lineage	lineage	NN	NN	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	ERP	erp	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	highly	highly	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	primarily	primarily	RB	RB	_	11	advmod	_	_
13	at	at	IN	IN	_	15	case	_	_
14	early	early	JJ	JJ	_	15	amod	_	_
15	stages	stage	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	B-lymphocyte	b-lymphocyte	NN	NN	_	18	compound	_	_
18	development	development	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	11	punct	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	expression	expression	NN	NN	_	22	nsubj	_	_
22	declines	decline	VBZ	VBZ	_	11	conj	_	_
23	drastically	drastically	RB	RB	_	22	advmod	_	_
24	upon	upon	IN	IN	_	26	case	_	_
25	B-cell	b-cell	NN	NN	_	26	compound	_	_
26	maturation	maturation	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	11	punct	_	_
28	correlating	correlate	VBG	VBG	_	11	conj	_	_
29	with	with	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	enhancer	enhancer	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	IgH	igh	NN	NN	_	37	compound	_	_
36	pi	pi	NN	NN	_	37	compound	_	_
37	site	site	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	ERP	erp	NN	NN	_	7	nsubj	_	_
6	might	might	MD	MD	_	7	aux	_	_
7	play	play	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	in	in	IN	IN	_	17	case	_	_
15	IgH	igh	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	regulation	regulation	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Patterns	patterns	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Pan	pan	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	role	role	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Pan	pan	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	endocrine	endocrine	NN	NN	_	13	nmod:npmod	_	_
12	cell	cell	NN	NN	_	13	nmod:npmod	_	_
13	type-specific	type-specific	JJ	JJ	_	15	amod	_	_
14	complex	complex	JJ	JJ	_	15	amod	_	_
15	formation	formation	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Pan	pan	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	at	at	IN	IN	_	6	case	_	_
6	least	least	JJS	JJS	_	7	nmod:npmod	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	distinct	distinct	JJ	JJ	_	9	amod	_	_
9	transcripts	transcript	NNS	NNS	_	4	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	Pan-1	pan-1	NN	NN	_	9	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Pan-2	pan-2	NN	NN	_	11	conj	_	_
14	(	(	-LRB-	-LRB-	_	11	punct	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	known	know	VBN	VBN	_	11	acl	_	_
17	as	as	IN	IN	_	18	case	_	_
18	E47	e47	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	E12	e12	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	respectively	respectively	RB	RB	_	18	advmod	_	_
23	)	)	-RRB-	-RRB-	_	11	punct	_	_
24	,	,	,	,	_	11	punct	_	_
25	by	by	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	mechanism	mechanism	NN	NN	_	4	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	alternative	alternative	JJ	JJ	_	31	amod	_	_
30	RNA	rna	NN	NN	_	31	compound	_	_
31	splicing	splicing	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Northern	northern	JJ	JJ	_	3	amod	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	11	nsubj	_	_
4	performed	perform	VBN	VBN	_	3	acl	_	_
5	on	on	IN	IN	_	9	case	_	_
6	rat	rat	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mouse	mouse	NN	NN	_	6	conj	_	_
9	tissues	tissue	NNS	NNS	_	4	nmod	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	ubiquitously	ubiquitously	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	15	amod	_	_
14	Pan	pan	NN	NN	_	15	compound	_	_
15	transcripts	transcript	NNS	NNS	_	11	dobj	_	_
16	,	,	,	,	_	11	punct	_	_
17	but	but	CC	CC	_	11	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	abundance	abundance	NN	NN	_	32	nsubjpass	_	_
20	,	,	,	,	_	19	punct	_	_
21	distribution	distribution	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	form	form	NN	NN	_	19	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	Pan	pan	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	19	nmod	_	_
28	have	have	VBP	VBP	_	32	aux	_	_
29	not	not	RB	RB	_	32	neg	_	_
30	been	be	VBN	VBN	_	32	auxpass	_	_
31	clearly	clearly	RB	RB	_	32	advmod	_	_
32	defined	define	VBN	VBN	_	11	conj	_	_
33	.	.	.	.	_	11	punct	_	_

1	Studies	study	NNS	NNS	_	21	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	1	nmod	_	_
5	representing	represent	VBG	VBG	_	4	acl	_	_
6	endocrine	endocrine	NN	NN	_	12	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	fibroblast	fibroblast	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	lymphoid	lymphoid	JJ	JJ	_	6	conj	_	_
12	lineages	lineage	NNS	NNS	_	5	dobj	_	_
13	using	use	VBG	VBG	_	1	acl	_	_
14	polyclonal	polyclonal	JJ	JJ	_	15	amod	_	_
15	antisera	antisera	NNS	NNS	_	13	dobj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	detect	detect	VB	VB	_	13	advcl	_	_
18	E2A	e2a	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	17	dobj	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	suggested	suggest	VBN	VBN	_	0	root	_	_
22	that	that	IN	IN	_	28	mark	_	_
23	significant	significant	JJ	JJ	_	26	amod	_	_
24	E2A	e2a	NN	NN	_	26	compound	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	28	nsubj	_	_
27	is	be	VBZ	VBZ	_	28	aux	_	_
28	restricted	restricted	JJ	JJ	_	21	ccomp	_	_
29	to	to	TO	TO	_	30	case	_	_
30	B-lymphocytes	b-lymphocyte	NNS	NNS	_	28	nmod	_	_
31	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	monoclonal	monoclonal	JJ	JJ	_	6	amod	_	_
6	antibody	antibody	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	Yae	yae	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	specific	specific	JJ	JJ	_	6	acl:relcl	_	_
13	for	for	IN	IN	_	15	case	_	_
14	Pan/E2A	pan/e2a	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	used	use	VBN	VBN	_	3	conj	_	_
20	the	the	DT	DT	_	22	det	_	_
21	Yae	yae	NN	NN	_	22	compound	_	_
22	antibody	antibody	NN	NN	_	19	dobj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	examine	examine	VB	VB	_	19	advcl	_	_
25	a	a	DT	DT	_	26	det	_	_
26	variety	variety	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	32	case	_	_
28	endocrine	endocrine	JJ	JJ	_	32	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	nonendocrine	nonendocrine	JJ	JJ	_	28	conj	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	lineages	lineage	NNS	NNS	_	26	nmod	_	_
33	for	for	IN	IN	_	34	case	_	_
34	differences	difference	NNS	NNS	_	24	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	Pan/E2A	pan/e2a	NN	NN	_	38	compound	_	_
37	protein	protein	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	subcellular	subcellular	JJ	JJ	_	41	amod	_	_
41	localization	localization	NN	NN	_	38	conj	_	_
42	,	,	,	,	_	38	punct	_	_
43	and	and	CC	CC	_	38	cc	_	_
44	heteromeric	heteromeric	JJ	JJ	_	46	amod	_	_
45	complex	complex	JJ	JJ	_	46	amod	_	_
46	formation	formation	NN	NN	_	38	conj	_	_
47	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	previous	previous	JJ	JJ	_	5	amod	_	_
5	results	result	NNS	NNS	_	16	nmod	_	_
6	obtained	obtain	VBN	VBN	_	5	acl	_	_
7	using	use	VBG	VBG	_	6	xcomp	_	_
8	polyclonal	polyclonal	JJ	JJ	_	9	amod	_	_
9	antiseras	antiseras	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	detect	detect	VB	VB	_	7	advcl	_	_
12	Pan/E2A	pan/e2a	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	11	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	report	report	VBP	VBP	_	0	root	_	_
17	comparable	comparable	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	Pan	pan	NN	NN	_	21	compound	_	_
21	proteins	protein	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	30	case	_	_
23	GH/PRL-	gh/prl-	NN	NN	_	30	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	insulin-producing	insulin-producing	JJ	JJ	_	23	conj	_	_
26	,	,	,	,	_	30	punct	_	_
27	B-	b-	NN	NN	_	30	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	T-lymphocyte	t-lymphocyte	NN	NN	_	27	conj	_	_
30	cells	cell	NNS	NNS	_	18	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	IEF-1	ief-1	NN	NN	_	15	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	pancreatic	pancreatic	JJ	JJ	_	6	amod	_	_
5	beta-cell	beta-cell	NN	NN	_	6	nmod:npmod	_	_
6	type-specific	type-specific	JJ	JJ	_	7	amod	_	_
7	complex	complex	NN	NN	_	1	appos	_	_
8	believed	believe	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	regulate	regulate	VB	VB	_	8	xcomp	_	_
11	insulin	insulin	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	1	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	consist	consist	VB	VB	_	15	xcomp	_	_
18	of	of	IN	IN	_	23	case	_	_
19	at	at	IN	IN	_	20	case	_	_
20	least	least	JJS	JJS	_	21	nmod:npmod	_	_
21	two	two	CD	CD	_	23	nummod	_	_
22	distinct	distinct	JJ	JJ	_	23	amod	_	_
23	species	species	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	one	one	CD	CD	_	30	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	which	which	WDT	WDT	_	25	nmod	_	_
28	does	do	VBZ	VBZ	_	30	aux	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	contain	contain	VB	VB	_	23	acl:relcl	_	_
31	Pan	pan	NN	NN	_	32	compound	_	_
32	molecules	molecule	NNS	NNS	_	30	dobj	_	_
33	.	.	.	.	_	15	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	it	it	PRP	PRP	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	postulated	postulate	VBN	VBN	_	26	advcl	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	pituitary	pituitary	JJ	JJ	_	9	amod	_	_
8	endocrine	endocrine	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	14	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	pancreatic	pancreatic	JJ	JJ	_	13	amod	_	_
12	endocrine	endocrine	NN	NN	_	13	compound	_	_
13	beta-cells	beta-cell	NNS	NNS	_	9	conj	_	_
14	share	share	VBP	VBP	_	5	ccomp	_	_
15	identical	identical	JJ	JJ	_	17	amod	_	_
16	Pan/E2A	pan/e2a	NN	NN	_	17	compound	_	_
17	complexes	complex	NNS	NNS	_	14	dobj	_	_
18	,	,	,	,	_	26	punct	_	_
19	native-Western	native-western	JJ	JJ	_	20	amod	_	_
20	analyses	analysis	NNS	NNS	_	26	nsubj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	pituitary	pituitary	JJ	JJ	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	endocrine	endocrine	JJ	JJ	_	22	conj	_	_
25	beta-cells	beta-cell	NNS	NNS	_	20	nmod	_	_
26	detect	detect	VBP	VBP	_	0	root	_	_
27	Pan	pan	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	26	dobj	_	_
29	in	in	IN	IN	_	33	case	_	_
30	distinct	distinct	JJ	JJ	_	33	amod	_	_
31	cell	cell	NN	NN	_	32	nmod:npmod	_	_
32	type-specific	type-specific	JJ	JJ	_	33	amod	_	_
33	complexes	complex	NNS	NNS	_	26	nmod	_	_
34	.	.	.	.	_	26	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	block	block	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	8	case	_	_
4	1	1	CD	CD	_	8	nummod	_	_
5	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	8	compound	_	_
6	D3-mediated	d3-mediated	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	regulation	regulation	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Elements	element	NNS	NNS	_	19	nsubj	_	_
2	necessary	necessary	JJ	JJ	_	1	amod	_	_
3	for	for	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	steroid	steroid	NN	NN	_	6	compound	_	_
6	hormone	hormone	NN	NN	_	15	nsubj	_	_
7	1	1	CD	CD	_	9	nummod	_	_
8	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	6	dep	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	1	1	CD	CD	_	12	nummod	_	_
12	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	6	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	induce	induce	VB	VB	_	1	acl	_	_
16	a	a	DT	DT	_	18	det	_	_
17	biological	biological	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	15	dobj	_	_
19	include	include	VBP	VBP	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	intracellular	intracellular	JJ	JJ	_	25	amod	_	_
25	receptors	receptor	NNS	NNS	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	vitamin	vitamin	NN	NN	_	29	compound	_	_
28	D3	d3	NN	NN	_	29	compound	_	_
29	receptors	receptor	NNS	NNS	_	25	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	VDR	vdr	NNS	NNS	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	)	)	-RRB-	-RRB-	_	29	punct	_	_
34	and	and	CC	CC	_	21	cc	_	_
35	modulation	modulation	NN	NN	_	21	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	35	nmod	_	_
39	via	via	IN	IN	_	41	case	_	_
40	hormone-activated	hormone-activated	JJ	JJ	_	41	amod	_	_
41	receptor	receptor	NN	NN	_	35	nmod	_	_
42	binding	bind	VBG	VBG	_	41	acl	_	_
43	to	to	TO	TO	_	45	case	_	_
44	regulatory	regulatory	JJ	JJ	_	45	amod	_	_
45	regions	region	NNS	NNS	_	42	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	target	target	NN	NN	_	48	compound	_	_
48	genes	gene	NNS	NNS	_	45	nmod	_	_
49	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	parameters	parameter	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	normal	normal	JJ	JJ	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
9	virus-immortalized	virus-immortalized	JJ	JJ	_	6	conj	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	dep	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	compared	compare	VBN	VBN	_	4	conj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	1	1	CD	CD	_	18	nummod	_	_
17	alpha,25-(OH)2D3-responsive	alpha,25-(oh)2d3-responsive	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	T	t	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	monocytic	monocytic	JJ	JJ	_	21	conj	_	_
24	lineages	lineage	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	resting	rest	VBG	VBG	_	5	amod	_	_
3	tonsillar	tonsillar	JJ	JJ	_	2	dep	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	express	express	VB	VB	_	18	advcl	_	_
9	VDR	vdr	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	18	punct	_	_
12	activation	activation	NN	NN	_	18	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	interleukin-4	interleukin-4	NN	NN	_	12	nmod	_	_
18	induced	induce	VBD	VBD	_	0	root	_	_
19	VDR	vdr	NN	NN	_	18	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	absence	absence	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	exogenously	exogenously	RB	RB	_	27	advmod	_	_
25	supplemented	supplement	VBN	VBN	_	27	amod	_	_
26	1	1	CD	CD	_	27	nummod	_	_
27	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	As	as	IN	IN	_	2	case	_	_
2	indicators	indicator	NNS	NNS	_	8	nmod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	hormone-mediated	hormone-mediated	JJ	JJ	_	6	amod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	regulation	regulation	NN	NN	_	2	nmod	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	analyzed	analyze	VBD	VBD	_	0	root	_	_
9	modulation	modulation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD23	cd23	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	18	det	_	_
14	common	common	JJ	JJ	_	18	amod	_	_
15	B	b	NN	NN	_	18	compound	_	_
16	cell/monocyte	cell/monocyte	NN	NN	_	18	compound	_	_
17	surface	surface	NN	NN	_	18	compound	_	_
18	antigen	antigen	NN	NN	_	11	appos	_	_
19	,	,	,	,	_	11	punct	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	24-hydroxylase	24-hydroxylase	NN	NN	_	11	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	1	1	CD	CD	_	2	nummod	_	_
2	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	CD23	cd23	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	U937	u937	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	yet	yet	RB	RB	_	11	advmod	_	_
11	failed	fail	VBD	VBD	_	3	dep	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	modulate	modulate	VB	VB	_	11	xcomp	_	_
14	CD23	cd23	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	1	1	CD	CD	_	4	nummod	_	_
4	alpha,25-(OH)2D3	alpha,25-(oh)2d3	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	24-hydroxylase	24-hydroxylase	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	5	dobj	_	_
8	expression	expression	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	metabolic	metabolic	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	7	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	lectin-activated	lectin-activated	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	conj	_	_
20	,	,	,	,	_	5	punct	_	_
21	yet	yet	RB	RB	_	22	advmod	_	_
22	failed	fail	VBD	VBD	_	5	dep	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	induce	induce	VB	VB	_	22	xcomp	_	_
25	24-hydroxylase	24-hydroxylase	NN	NN	_	26	compound	_	_
26	mRNA	mrna	NN	NN	_	24	dobj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
29	metabolic	metabolic	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	26	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	24	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	although	although	IN	IN	_	10	mark	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	express	express	VB	VB	_	17	advcl	_	_
11	VDR	vdr	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	protein	protein	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	17	punct	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	exhibit	exhibit	VBP	VBP	_	3	ccomp	_	_
18	a	a	DT	DT	_	20	det	_	_
19	functional	functional	JJ	JJ	_	20	amod	_	_
20	block	block	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	25	case	_	_
22	vitamin	vitamin	NN	NN	_	23	nmod:npmod	_	_
23	D-dependent	d-dependent	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	regulation	regulation	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Interferon	interferon	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	4	nsubj	_	_
3	selectively	selectively	RB	RB	_	4	advmod	_	_
4	affects	affect	VBZ	VBZ	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	human	human	JJ	JJ	_	13	amod	_	_
9	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
10	cell	cell	NN	NN	_	13	compound	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	differentiation	differentiation	NN	NN	_	13	compound	_	_
13	antigen	antigen	NN	NN	_	5	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	late	late	JJ	JJ	_	17	amod	_	_
16	stage	stage	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	5	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	monocytic	monocytic	JJ	JJ	_	17	nmod	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	20	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	granulocytic	granulocytic	JJ	JJ	_	20	conj	_	_
25	lineage	lineage	NN	NN	_	20	dep	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	differentiation	differentiation	NN	NN	_	7	compound	_	_
7	antigen	antigen	NN	NN	_	12	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MNDA	mnda	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	0	root	_	_
13	constitutively	constitutively	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
19	lineage	lineage	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	appearing	appear	VBG	VBG	_	12	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	myeloblast	myeloblast	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	some	some	DT	DT	_	27	det	_	_
27	cases	case	NNS	NNS	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	acute	acute	JJ	JJ	_	31	amod	_	_
30	myeloid	myeloid	JJ	JJ	_	31	amod	_	_
31	leukemia	leukemia	NN	NN	_	27	nmod	_	_
32	and	and	CC	CC	_	21	cc	_	_
33	consistently	consistently	RB	RB	_	35	advmod	_	_
34	being	be	VBG	VBG	_	35	auxpass	_	_
35	detected	detect	VBN	VBN	_	21	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	promyelocyte	promyelocyte	JJ	JJ	_	39	amod	_	_
38	stage	stage	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	as	as	RB	RB	_	39	cc	_	_
41	well	well	RB	RB	_	40	mwe	_	_
42	as	as	IN	IN	_	40	mwe	_	_
43	in	in	IN	IN	_	47	case	_	_
44	all	all	DT	DT	_	47	det	_	_
45	later	later	JJR	JJR	_	47	amod	_	_
46	stage	stage	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	39	conj	_	_
48	including	include	VBG	VBG	_	51	case	_	_
49	peripheral	peripheral	JJ	JJ	_	51	amod	_	_
50	blood	blood	NN	NN	_	51	compound	_	_
51	monocytes	monocyte	NNS	NNS	_	47	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	granulocytes	granulocyte	NNS	NNS	_	51	conj	_	_
54	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	15	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	HL-60	hl-60	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	U937	u937	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	THP-1	thp-1	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	express	express	VBP	VBP	_	0	root	_	_
16	similar	similar	JJ	JJ	_	17	amod	_	_
17	levels	level	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	immunochemically	immunochemically	RB	RB	_	20	advmod	_	_
20	detectable	detectable	JJ	JJ	_	21	amod	_	_
21	MNDA	mnda	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	level	level	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	MNDA	mnda	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	primary	primary	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	low	low	JJ	JJ	_	16	advcl	_	_
14	it	it	PRP	PRP	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
17	at	at	IN	IN	_	19	case	_	_
18	6	6	CD	CD	_	19	nummod	_	_
19	h	h	NN	NN	_	16	nmod	_	_
20	following	follow	VBG	VBG	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	addition	addition	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	interferon	interferon	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	interferon	interferon	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	MNDA	mnda	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	12	nmod	_	_
17	HL-60	hl-60	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	U937	u937	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	THP-1	thp-1	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	MNDA	mnda	NN	NN	_	4	compound	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	level	level	NN	NN	_	9	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	primary	primary	JJ	JJ	_	7	amod	_	_
7	granulocytes	granulocyte	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	aux	_	_
9	unaffected	unaffected	JJ	JJ	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	addition	addition	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	interferon	interferon	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	agents	agent	NNS	NNS	_	14	conj	_	_
18	including	include	VBG	VBG	_	20	case	_	_
19	interferon	interferon	NN	NN	_	20	compound	_	_
20	gamma	gamma	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	endotoxin	endotoxin	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	poly(I).poly(C)	poly(i).poly(c)	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	FMLP	fmlp	NN	NN	_	20	conj	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	MNDA	mnda	NN	NN	_	4	compound	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	level	level	NN	NN	_	12	nsubj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	4	nmod	_	_
10	was	be	VBD	VBD	_	12	aux	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	unaffected	unaffected	JJ	JJ	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	latter	latter	JJ	JJ	_	17	amod	_	_
16	four	four	CD	CD	_	17	nummod	_	_
17	agents	agent	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Induction	induction	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	differentiation	differentiation	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	myeloid	myeloid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	1	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	phorbol	phorbol	NN	NN	_	11	compound	_	_
11	ester	ester	NN	NN	_	1	nmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	monocyte	monocyte	NN	NN	_	14	compound	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	accompanied	accompany	VBN	VBN	_	14	acl:relcl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	decrease	decrease	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	MNDA	mnda	NN	NN	_	24	compound	_	_
23	mRNA	mrna	NN	NN	_	24	compound	_	_
24	level	level	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	reduced	reduced	JJ	JJ	_	3	amod	_	_
3	level	level	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	mRNA	mrna	NN	NN	_	3	nmod	_	_
6	could	could	MD	MD	_	9	aux	_	_
7	then	then	RB	RB	_	9	advmod	_	_
8	be	be	VB	VB	_	9	aux	_	_
9	elevated	elevated	JJ	JJ	_	0	root	_	_
10	with	with	IN	IN	_	14	case	_	_
11	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
12	interferon	interferon	NN	NN	_	14	compound	_	_
13	alpha	alpha	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	phorbol	phorbol	NN	NN	_	5	compound	_	_
5	ester	ester	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	MNDA	mnda	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	2	nmod	_	_
9	appeared	appear	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	9	xcomp	_	_
13	with	with	IN	IN	_	15	case	_	_
14	induced	induce	VBN	VBN	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	since	since	IN	IN	_	22	mark	_	_
17	inhibiting	inhibit	VBG	VBG	_	22	csubj	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	proliferation	proliferation	NN	NN	_	17	dobj	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	alter	alter	VB	VB	_	9	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	level	level	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	MNDA	mnda	NN	NN	_	27	compound	_	_
27	mRNA	mrna	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	cell	cell	NN	NN	_	31	compound	_	_
30	cycle	cycle	NN	NN	_	31	compound	_	_
31	variation	variation	NN	NN	_	38	nsubjpass	_	_
32	in	in	IN	IN	_	35	case	_	_
33	MNDA	mnda	NN	NN	_	35	compound	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	levels	level	NNS	NNS	_	31	nmod	_	_
36	were	be	VBD	VBD	_	38	auxpass	_	_
37	not	not	RB	RB	_	38	neg	_	_
38	observed	observe	VBN	VBN	_	22	conj	_	_
39	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	interferon	interferon	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	up-regulate	up-regulate	VB	VB	_	2	acl	_	_
8	MNDA	mnda	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	16	case	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	ester	ester	NN	NN	_	13	nmod:npmod	_	_
13	treated	treated	JJ	JJ	_	16	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	7	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	consistent	consistent	JJ	JJ	_	0	root	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	observations	observation	NNS	NNS	_	18	nmod	_	_
22	made	make	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	primary	primary	JJ	JJ	_	25	amod	_	_
25	monocytes	monocyte	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	(	(	-LRB-	-LRB-	_	3	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	3	nsubj	_	_
3	TRUNCATED	truncate	VBN	VBN	_	0	root	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	alpha-lipoic	alpha-lipoic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	dihydrolipoic	dihydrolipoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	4	conj	_	_
8	on	on	IN	IN	_	9	case	_	_
9	expression	expression	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	proto-oncogene	proto-oncogene	NN	NN	_	12	compound	_	_
12	c-fos	c-fos	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	9	nsubj	_	_
4	AP-1	ap-1	NN	NN	_	3	dep	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	an	a	DT	DT	_	9	det	_	_
7	important	important	JJ	JJ	_	9	amod	_	_
8	human	human	JJ	JJ	_	7	dep	_	_
9	mediator	mediator	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	response	response	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	serum	serum	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	growth	growth	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	15	appos	_	_
19	,	,	,	,	_	15	punct	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	phorbol	phorbol	NN	NN	_	22	compound	_	_
22	esters	ester	NNS	NNS	_	15	conj	_	_
23	such	such	JJ	JJ	_	26	case	_	_
24	as	as	IN	IN	_	23	mwe	_	_
25	12-O-tetradecanoyl-phorbol-13	12-o-tetradecanoyl-phorbol-13	NN	NN	_	26	compound	_	_
26	acetate	acetate	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	TPA	tpa	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	AP-1	ap-1	NN	NN	_	3	compound	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	consists	consist	VBZ	VBZ	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	distinct	distinct	JJ	JJ	_	8	amod	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	heterodimers	heterodimer	NNS	NNS	_	4	nmod	_	_
9	encoded	encode	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	proto-oncogene	proto-oncogene	NN	NN	_	9	nmod	_	_
13	c-fos	c-fos	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	c-jun	c-jun	NN	NN	_	12	conj	_	_
16	mRNA	mrna	NN	NN	_	12	dep	_	_
17	whose	whose	WP$	WP$	_	19	nmod:poss	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	22	nsubjpass	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	induced	induce	VBN	VBN	_	12	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	TPA	tpa	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	cyclic	cyclic	JJ	JJ	_	27	amod	_	_
27	AMP	amp	NN	NN	_	24	conj	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	growth	growth	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	24	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	reactive	reactive	JJ	JJ	_	9	amod	_	_
8	oxygen	oxygen	NN	NN	_	9	compound	_	_
9	species	species	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	pathway	pathway	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	TPA	tpa	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	14	conj	_	_
19	leading	lead	VBG	VBG	_	12	acl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	c-fos	c-fos	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	c-jun	c-jun	NN	NN	_	23	conj	_	_
26	mRNA	mrna	NN	NN	_	23	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	reactive	reactive	JJ	JJ	_	8	amod	_	_
7	oxygen	oxygen	NN	NN	_	8	compound	_	_
8	species	species	NNS	NNS	_	4	nmod	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	studied	study	VBD	VBD	_	2	parataxis	_	_
11	the	the	DT	DT	_	12	det	_	_
12	effects	effect	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	alpha-lipoic	alpha-lipoic	JJ	JJ	_	15	amod	_	_
15	acid	acid	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	dihydrolipoic	dihydrolipoic	JJ	JJ	_	18	amod	_	_
18	acid	acid	NN	NN	_	15	conj	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	natural	natural	JJ	JJ	_	22	amod	_	_
21	thiol	thiol	NN	NN	_	22	compound	_	_
22	antioxidants	antioxidant	NNS	NNS	_	18	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	on	on	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	12	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	c-fos	c-fos	NN	NN	_	29	compound	_	_
29	mRNA	mrna	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	34	case	_	_
31	human	human	JJ	JJ	_	34	amod	_	_
32	Jurkat	jurkat	NN	NN	_	34	compound	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	26	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	preincubated	preincubate	VBN	VBN	_	18	advcl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	dihydrolipoic	dihydrolipoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	0.2	0.2	CD	CD	_	10	nummod	_	_
10	mM	mm	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	18	nsubjpass	_	_
14	of	of	IN	IN	_	16	case	_	_
15	c-fos	c-fos	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	13	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	suppressed	suppress	VBN	VBN	_	0	root	_	_
19	at	at	IN	IN	_	21	case	_	_
20	30	30	CD	CD	_	21	nummod	_	_
21	min	min	NN	NN	_	18	nmod	_	_
22	after	after	IN	IN	_	23	case	_	_
23	stimulation	stimulation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	TPA	tpa	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	0.5	0.5	CD	CD	_	28	nummod	_	_
28	microM	microm	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	whereas	whereas	IN	IN	_	47	mark	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	case	case	NN	NN	_	47	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	preincubation	preincubation	NN	NN	_	33	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	alpha-lipoic	alpha-lipoic	JJ	JJ	_	38	amod	_	_
38	acid	acid	NN	NN	_	35	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	0.2	0.2	CD	CD	_	41	nummod	_	_
41	microM	microm	NN	NN	_	38	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	47	punct	_	_
44	the	the	DT	DT	_	45	det	_	_
45	expression	expression	NN	NN	_	47	nsubjpass	_	_
46	was	be	VBD	VBD	_	47	auxpass	_	_
47	enhanced	enhance	VBN	VBN	_	18	advcl	_	_
48	at	at	IN	IN	_	50	case	_	_
49	30	30	CD	CD	_	50	nummod	_	_
50	min	min	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	idea	idea	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	superoxide	superoxide	NN	NN	_	9	compound	_	_
8	anion	anion	NN	NN	_	9	compound	_	_
9	radical	radical	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	5	ccomp	_	_
11	a	a	DT	DT	_	12	det	_	_
12	role	role	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	c-fos	c-fos	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	proto-oncogene	proto-oncogene	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	cytokine	cytokine	NN	NN	_	3	conj	_	_
6	expression	expression	NN	NN	_	3	dep	_	_
7	in	in	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	16	det	_	_
14	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	11	conj	_	_
17	THP-1	thp-1	NN	NN	_	16	dep	_	_
18	after	after	IN	IN	_	19	case	_	_
19	stimulation	stimulation	NN	NN	_	1	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	mycoplasma-derived	mycoplasma-derived	JJ	JJ	_	22	amod	_	_
22	material	material	NN	NN	_	19	nmod	_	_
23	MDHM	mdhm	NN	NN	_	22	dep	_	_
24	.	.	.	.	_	1	punct	_	_

1	Mycoplasma	mycoplasma	NN	NN	_	4	compound	_	_
2	fermentans-derived	fermentans-derived	JJ	JJ	_	4	amod	_	_
3	high-molecular-weight	high-molecular-weight	JJ	JJ	_	4	amod	_	_
4	material	material	NN	NN	_	10	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	MDHM	mdhm	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	originally	originally	RB	RB	_	10	advmod	_	_
10	described	describe	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	induce	induce	VB	VB	_	10	xcomp	_	_
13	differentiation	differentiation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	murine	murine	NN	NN	_	16	compound	_	_
16	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	cytolytic	cytolytic	JJ	JJ	_	20	amod	_	_
19	effector	effector	NN	NN	_	20	compound	_	_
20	T-cells	t-cell	NNS	NNS	_	13	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	stimulating	stimulate	VBG	VBG	_	12	advcl	_	_
23	IL-6	il-6	NN	NN	_	24	compound	_	_
24	release	release	NN	NN	_	22	dobj	_	_
25	from	from	IN	IN	_	27	case	_	_
26	adherent	adherent	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	monocytes	monocyte	NNS	NNS	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PBMo	pbmo	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	respond	respond	VBP	VBP	_	3	ccomp	_	_
14	to	to	TO	TO	_	15	case	_	_
15	MDHM	mdhm	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	increases	increase	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	IL-1	il-1	NN	NN	_	20	compound	_	_
20	beta	beta	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	IL-6	il-6	NN	NN	_	20	conj	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	TNF	tnf	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	20	conj	_	_
26	expression	expression	NN	NN	_	20	dep	_	_
27	,	,	,	,	_	17	punct	_	_
28	both	both	CC	CC	_	17	dep	_	_
29	at	at	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	dep	_	_
31	mRNA	mrna	NN	NN	_	17	conj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	protein	protein	NN	NN	_	31	conj	_	_
34	level	level	NN	NN	_	31	dep	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	induced	induce	VBN	VBN	_	3	amod	_	_
3	expression	expression	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	IL-1	il-1	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TNF	tnf	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	6	conj	_	_
10	mRNA	mrna	NN	NN	_	6	dep	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
14	THP-1	thp-1	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	3	nmod	_	_
17	increased	increase	VBD	VBD	_	0	root	_	_
18	as	as	RB	RB	_	19	advmod	_	_
19	quickly	quickly	RB	RB	_	17	xcomp	_	_
20	as	as	IN	IN	_	23	case	_	_
21	in	in	IN	IN	_	23	case	_	_
22	primary	primary	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	16	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	PBMo	pbmo	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	THP-1	thp-1	NN	NN	_	16	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	14	14	CD	CD	_	11	nummod	_	_
9	other	other	JJ	JJ	_	11	amod	_	_
10	monocytic/myeloid	monocytic/myeloid	JJ	JJ	_	11	amod	_	_
11	leukemia-derived	leukemia-derived	JJ	JJ	_	6	conj	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	6	dep	_	_
14	did	do	VBD	VBD	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	secrete	secrete	VB	VB	_	0	root	_	_
17	measurable	measurable	JJ	JJ	_	18	amod	_	_
18	amounts	amount	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
22	upon	upon	IN	IN	_	23	case	_	_
23	treatment	treatment	NN	NN	_	16	nmod	_	_
24	with	with	IN	IN	_	25	case	_	_
25	MDHM	mdhm	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	IL-1	il-1	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-6	il-6	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	2	conj	_	_
6	contain	contain	VBP	VBP	_	0	root	_	_
7	AP-1	ap-1	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	6	dobj	_	_
10	as	as	IN	IN	_	12	case	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	12	appos	_	_
17	being	be	VBG	VBG	_	18	auxpass	_	_
18	composed	compose	VBN	VBN	_	16	acl	_	_
19	of	of	IN	IN	_	20	case	_	_
20	c-jun	c-jun	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	c-fos	c-fos	NN	NN	_	20	conj	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	products	product	NNS	NNS	_	20	dep	_	_
25	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	THP-1	thp-1	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	c-jun	c-jun	NN	NN	_	6	compound	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	7	nsubj	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	after	after	IN	IN	_	9	case	_	_
9	incubation	incubation	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	MDHM	mdhm	NN	NN	_	9	nmod	_	_
12	while	while	IN	IN	_	16	mark	_	_
13	positive	positive	JJ	JJ	_	15	amod	_	_
14	c-fos	c-fos	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	16	nsubj	_	_
16	remained	remain	VBD	VBD	_	7	advcl	_	_
17	unaffected	unaffected	JJ	JJ	_	16	xcomp	_	_
18	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	17	advcl	_	_
5	AP-1	ap-1	NN	NN	_	6	nsubj	_	_
6	regulated	regulate	VBD	VBD	_	4	ccomp	_	_
7	cytokine	cytokine	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	17	punct	_	_
11	results	result	NNS	NNS	_	17	nsubj	_	_
12	from	from	IN	IN	_	13	case	_	_
13	PBMo	pbmo	NN	NN	_	11	nmod	_	_
14	are	be	VBP	VBP	_	17	cop	_	_
15	not	not	RB	RB	_	17	neg	_	_
16	in	in	IN	IN	_	17	case	_	_
17	accordance	accordance	NN	NN	_	0	root	_	_
18	with	with	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	notion	notion	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	primary	primary	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	12	nmod	_	_
5	MDHM-induced	mdhm-induced	JJ	JJ	_	6	amod	_	_
6	elevation	elevation	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	cytokine	cytokine	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	preceded	precede	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	downregulation	downregulation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	c-fos	c-fos	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	while	while	IN	IN	_	25	mark	_	_
20	positive	positive	JJ	JJ	_	22	amod	_	_
21	c-jun	c-jun	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	25	nsubjpass	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	modulated	modulate	VBN	VBN	_	12	advcl	_	_
26	.	.	.	.	_	12	punct	_	_

1	c-myc	c-myc	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	12	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	constitutively	constitutively	RB	RB	_	3	advmod	_	_
6	high	high	JJ	JJ	_	3	amod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	THP-1	thp-1	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	MDHM-stimulated	mdhm-stimulated	JJ	JJ	_	15	amod	_	_
15	PBMo	pbmo	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	MDHM-stimulated	mdhm-stimulated	JJ	JJ	_	5	amod	_	_
5	induction	induction	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	cytokine	cytokine	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	accompanied	accompany	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	proto-oncogene	proto-oncogene	NN	NN	_	15	compound	_	_
15	responses	response	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	PBMo	pbmo	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	THP-1	thp-1	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	represent	represent	VB	VB	_	0	root	_	_
5	different	different	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	5	dep	_	_
7	pathways	pathway	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	systems	system	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Alternatively	alternatively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	support	support	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	notion	notion	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	16	mark	_	_
9	neither	neither	CC	CC	_	10	cc:preconj	_	_
10	AP-1	ap-1	NN	NN	_	16	nsubjpass	_	_
11	nor	nor	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	c-myc	c-myc	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	10	conj	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	7	ccomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	MDHM-induced	mdhm-induced	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	IL-1	il-1	NN	NN	_	23	compound	_	_
23	beta	beta	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	IL-6	il-6	NN	NN	_	23	conj	_	_
26	or	or	CC	CC	_	23	cc	_	_
27	TNF	tnf	NN	NN	_	29	compound	_	_
28	alpha	alpha	NN	NN	_	29	compound	_	_
29	mRNA	mrna	NN	NN	_	23	conj	_	_
30	levels	level	NNS	NNS	_	23	dep	_	_
31	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	present	present	JJ	JJ	_	5	amod	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	clearly	clearly	RB	RB	_	6	advmod	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	mycoplasma	mycoplasma	NN	NN	_	10	compound	_	_
10	products	product	NNS	NNS	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	have	have	VB	VB	_	6	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	profound	profound	JJ	JJ	_	15	amod	_	_
15	impact	impact	NN	NN	_	12	dobj	_	_
16	on	on	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	activation	activation	NN	NN	_	19	compound	_	_
19	status	status	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	eukaryotic	eukaryotic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	All-trans	all-trans	JJ	JJ	_	3	amod	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	1	1	CD	CD	_	7	nummod	_	_
6	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	7	compound	_	_
7	D3	d3	NN	NN	_	3	conj	_	_
8	co-operate	co-operate	VBP	VBP	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	promote	promote	VB	VB	_	8	xcomp	_	_
11	differentiation	differentiation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	promyeloid	promyeloid	JJ	JJ	_	18	amod	_	_
16	leukemia	leukemia	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	11	nmod	_	_
19	HL60	hl60	NN	NN	_	18	dep	_	_
20	to	to	TO	TO	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	basis	basis	NN	NN	_	9	nsubjpass	_	_
3	for	for	IN	IN	_	5	case	_	_
4	differentiation	differentiation	NN	NN	_	5	compound	_	_
5	therapy	therapy	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	leukemias	leukemia	NNS	NNS	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	provided	provide	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	knowledge	knowledge	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	agents	agent	NNS	NNS	_	11	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	induce	induce	VBP	VBP	_	13	acl:relcl	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	lineage	lineage	NN	NN	_	18	compound	_	_
18	maturation	maturation	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	9	punct	_	_

1	All-trans	all-trans	JJ	JJ	_	3	amod	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	RA	ra	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	differentiation	differentiation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	HL60	hl60	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	neutrophils	neutrophil	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	used	use	VBN	VBN	_	7	conj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	treat	treat	VB	VB	_	16	xcomp	_	_
19	acute	acute	JJ	JJ	_	21	amod	_	_
20	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	RA	ra	NN	NN	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	induced	induce	VBN	VBN	_	2	ccomp	_	_
8	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	serum-free	serum-free	JJ	JJ	_	14	amod	_	_
12	grown	grow	VBN	VBN	_	14	amod	_	_
13	HL60	hl60	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	whereas	whereas	IN	IN	_	24	mark	_	_
16	50	50	CD	CD	_	17	compound	_	_
17	nM	nm	NN	NN	_	20	nummod	_	_
18	1	1	CD	CD	_	20	nummod	_	_
19	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	20	compound	_	_
20	D3	d3	NN	NN	_	24	nsubj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	D3	d3	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	induced	induce	VBD	VBD	_	7	advcl	_	_
25	maximal	maximal	JJ	JJ	_	27	amod	_	_
26	monocyte	monocyte	NN	NN	_	27	compound	_	_
27	differentiation	differentiation	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	2	punct	_	_

1	Increasing	increase	VBG	VBG	_	3	amod	_	_
2	RA	ra	NN	NN	_	3	compound	_	_
3	concentrations	concentration	NNS	NNS	_	4	nsubj	_	_
4	reduced	reduce	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	D3	d3	NN	NN	_	7	compound	_	_
7	concentration	concentration	NN	NN	_	4	dobj	_	_
8	required	require	VBN	VBN	_	7	acl	_	_
9	for	for	IN	IN	_	11	case	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Cells	cell	NNS	NNS	_	7	nsubj	_	_
2	treated	treat	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	6	case	_	_
4	5	5	CD	CD	_	5	compound	_	_
5	nM	nm	NN	NN	_	6	amod	_	_
6	D3	d3	NN	NN	_	2	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	little	little	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	differentiated	differentiate	VBD	VBD	_	7	conj	_	_
13	maximally	maximally	RB	RB	_	12	advmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	5	5	CD	CD	_	16	compound	_	_
16	nM	nm	NN	NN	_	17	amod	_	_
17	D3	d3	NN	NN	_	12	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	10	10	CD	CD	_	20	compound	_	_
20	nM	nm	NN	NN	_	21	amod	_	_
21	RA	ra	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	D3	d3	NN	NN	_	3	compound	_	_
3	analogs	analog	NNS	NNS	_	12	nsubj	_	_
4	MC903	mc903	NN	NN	_	3	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	EB1089	eb1089	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	KH1060	kh1060	NN	NN	_	4	conj	_	_
9	were	be	VBD	VBD	_	12	cop	_	_
10	more	more	JJR	JJR	_	11	dep	_	_
11	potent	potent	JJ	JJ	_	12	amod	_	_
12	inducers	inducer	NNS	NNS	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	monocyte	monocyte	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	extent	extent	NN	NN	_	15	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	which	which	WDT	WDT	_	8	nmod	_	_
5	analog	analog	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	increased	increase	VBN	VBN	_	2	acl:relcl	_	_
9	after	after	IN	IN	_	10	case	_	_
10	cotreatment	cotreatment	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	RA	ra	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	15	cop	_	_
14	inversely	inversely	RB	RB	_	15	advmod	_	_
15	related	related	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	potency	potency	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	Twenty-four	twenty-four	CD	CD	_	2	compound	_	_
2	hour	hour	NN	NN	_	3	amod	_	_
3	treatment	treatment	NN	NN	_	8	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	10	10	CD	CD	_	6	compound	_	_
6	nM	nm	NN	NN	_	7	amod	_	_
7	RA	ra	NN	NN	_	3	nmod	_	_
8	primed	prime	VBD	VBD	_	0	root	_	_
9	cells	cell	NNS	NNS	_	8	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	response	response	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	5	5	CD	CD	_	14	compound	_	_
14	nM	nm	NN	NN	_	15	amod	_	_
15	D3	d3	NN	NN	_	11	nmod	_	_
16	;	;	:	:	_	8	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	reverse	reverse	NN	NN	_	19	compound	_	_
19	sequence	sequence	NN	NN	_	21	nsubj	_	_
20	being	be	VBG	VBG	_	21	cop	_	_
21	ineffective	ineffective	JJ	JJ	_	8	parataxis	_	_
22	.	.	.	.	_	8	punct	_	_

1	Priming	prime	VBG	VBG	_	19	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	10	10	CD	CD	_	4	compound	_	_
4	nM	nm	NN	NN	_	5	nummod	_	_
5	RA	ra	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	or	or	CC	CC	_	1	cc	_	_
8	subsequent	subsequent	JJ	JJ	_	9	amod	_	_
9	treatment	treatment	NN	NN	_	1	conj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	D3	d3	NN	NN	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	5	5	CD	CD	_	14	nummod	_	_
14	nM	nm	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	1	punct	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	alter	alter	VB	VB	_	0	root	_	_
20	expression	expression	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	mRNAs	mrna	NNS	NNS	_	24	compound	_	_
23	encoding	encode	VBG	VBG	_	24	amod	_	_
24	receptors	receptor	NNS	NNS	_	20	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	D3	d3	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	VDR	vdr	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	26	punct	_	_
31	RA	ra	NN	NN	_	26	conj	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	RAR	rar	NN	NN	_	34	compound	_	_
34	alpha	alpha	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	or	or	CC	CC	_	26	cc	_	_
37	9-CIS	9-cis	JJ	JJ	_	38	amod	_	_
38	RA	ra	NN	NN	_	26	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	RXR	rxr	NN	NN	_	38	appos	_	_
41	alpha	alpha	NN	NN	_	40	dep	_	_
42	,	,	,	,	_	40	punct	_	_
43	beta	beta	NN	NN	_	40	appos	_	_
44	,	,	,	,	_	40	punct	_	_
45	gamma	gamma	NN	NN	_	40	appos	_	_
46	)	)	-RRB-	-RRB-	_	40	punct	_	_
47	.	.	.	.	_	19	punct	_	_

1	That	that	IN	IN	_	3	mark	_	_
2	RA	ra	NN	NN	_	3	nsubj	_	_
3	promotes	promote	VBZ	VBZ	_	9	csubj	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	neutrophil	neutrophil	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	monocyte	monocyte	NN	NN	_	5	conj	_	_
8	differentiation	differentiation	NN	NN	_	5	dep	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	implications	implication	NNS	NNS	_	9	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	use	use	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	RA	ra	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	D3	d3	NN	NN	_	15	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	treatment	treatment	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	leukemias	leukemia	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	provides	provide	VBZ	VBZ	_	9	conj	_	_
24	insight	insight	NN	NN	_	23	dobj	_	_
25	into	into	IN	IN	_	26	case	_	_
26	mechanisms	mechanism	NNS	NNS	_	24	nmod	_	_
27	whereby	whereby	WRB	WRB	_	33	advmod	_	_
28	RAR	rar	NN	NN	_	33	nsubj	_	_
29	,	,	,	,	_	28	punct	_	_
30	VDR	vdr	NN	NN	_	28	conj	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	RXR	rxr	NN	NN	_	28	conj	_	_
33	facilitate	facilitate	VBP	VBP	_	26	acl:relcl	_	_
34	monocyte	monocyte	NN	NN	_	35	compound	_	_
35	differentiation	differentiation	NN	NN	_	33	dobj	_	_
36	.	.	.	.	_	9	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	RNA	rna	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
6	encoded	encode	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	murine	murine	NN	NN	_	13	compound	_	_
10	p105	p105	NN	NN	_	13	compound	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	6	nmod	_	_
14	generates	generate	VBZ	VBZ	_	0	root	_	_
15	I	i	NN	NN	_	19	compound	_	_
16	kappa	kappa	NN	NN	_	19	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	gamma	gamma	NN	NN	_	19	compound	_	_
19	isoforms	isoform	NNS	NNS	_	14	dobj	_	_
20	with	with	IN	IN	_	23	case	_	_
21	different	different	JJ	JJ	_	23	amod	_	_
22	inhibitory	inhibitory	JJ	JJ	_	21	dep	_	_
23	activities	activity	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	21	nsubj	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	10	det	_	_
5	105-kDa	105-kda	JJ	JJ	_	10	amod	_	_
6	protein	protein	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	p105	p105	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	precursor	precursor	NN	NN	_	3	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	p50	p50	NN	NN	_	14	compound	_	_
14	subunit	subunit	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	transcription	transcription	NN	NN	_	19	compound	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	14	nmod	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	encodes	encode	VBZ	VBZ	_	0	root	_	_
22	a	a	DT	DT	_	27	det	_	_
23	p70	p70	NN	NN	_	27	compound	_	_
24	I	i	NN	NN	_	27	compound	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	21	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	I	i	NN	NN	_	32	compound	_	_
30	kappa	kappa	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	gamma	gamma	NN	NN	_	27	appos	_	_
33	,	,	,	,	_	27	punct	_	_
34	which	which	WDT	WDT	_	36	nsubj	_	_
35	is	be	VBZ	VBZ	_	36	cop	_	_
36	identical	identical	JJ	JJ	_	27	acl:relcl	_	_
37	to	to	TO	TO	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	C-terminal	c-terminal	JJ	JJ	_	42	amod	_	_
40	607	607	CD	CD	_	42	nummod	_	_
41	amino	amino	NN	NN	_	42	compound	_	_
42	acids	acid	NNS	NNS	_	36	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	p105	p105	NN	NN	_	42	nmod	_	_
45	.	.	.	.	_	21	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	alternative	alternative	JJ	JJ	_	7	amod	_	_
6	RNA	rna	NN	NN	_	7	compound	_	_
7	splicing	splicing	NN	NN	_	8	nsubj	_	_
8	generates	generate	VBZ	VBZ	_	3	ccomp	_	_
9	I	i	NN	NN	_	13	compound	_	_
10	kappa	kappa	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	gamma	gamma	NN	NN	_	13	compound	_	_
13	isoforms	isoform	NNS	NNS	_	8	dobj	_	_
14	with	with	IN	IN	_	15	case	_	_
15	properties	property	NNS	NNS	_	13	nmod	_	_
16	different	different	JJ	JJ	_	15	amod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	those	those	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	p70	p70	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	63-kDa	63-kda	JJ	JJ	_	3	amod	_	_
3	isoform	isoform	NN	NN	_	22	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	termed	term	VBN	VBN	_	3	acl	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	gamma-1	gamma-1	NN	NN	_	5	xcomp	_	_
10	,	,	,	,	_	3	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	lacks	lack	VBZ	VBZ	_	3	acl:relcl	_	_
13	59	59	CD	CD	_	15	nummod	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	12	dobj	_	_
16	C-terminal	c-terminal	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	ankyrin	ankyrin	NN	NN	_	19	compound	_	_
19	repeat	repeat	NN	NN	_	15	nmod	_	_
20	7	7	CD	CD	_	19	nummod	_	_
21	,	,	,	,	_	3	punct	_	_
22	has	have	VBZ	VBZ	_	0	root	_	_
23	a	a	DT	DT	_	28	det	_	_
24	novel	novel	JJ	JJ	_	28	amod	_	_
25	35-amino	35-amino	NN	NN	_	28	compound	_	_
26	acid	acid	NN	NN	_	28	compound	_	_
27	C	c	NN	NN	_	28	compound	_	_
28	terminus	terminus	NN	NN	_	22	dobj	_	_
29	encoded	encode	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	34	case	_	_
31	an	a	DT	DT	_	34	det	_	_
32	alternative	alternative	JJ	JJ	_	34	amod	_	_
33	reading	reading	NN	NN	_	34	compound	_	_
34	frame	frame	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	p105	p105	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	22	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	55-kDa	55-kda	JJ	JJ	_	3	amod	_	_
3	isoform	isoform	NN	NN	_	10	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	gamma-2	gamma-2	NN	NN	_	3	appos	_	_
9	,	,	,	,	_	3	punct	_	_
10	lacks	lack	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	15	det	_	_
12	190	190	CD	CD	_	15	nummod	_	_
13	C-terminal	c-terminal	JJ	JJ	_	15	amod	_	_
14	amino	amino	NN	NN	_	15	compound	_	_
15	acids	acid	NNS	NNS	_	10	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	p70I	p70i	NN	NN	_	20	compound	_	_
18	kappa	kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	gamma	gamma	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	to	to	TO	TO	_	7	case	_	_
4	p70I	p70i	NN	NN	_	7	compound	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	gamma	gamma	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	13	nsubj	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	cytoplasmic	cytoplasmic	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	7	acl:relcl	_	_
14	,	,	,	,	_	20	punct	_	_
15	I	i	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	gamma-1	gamma-1	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	cytoplasm	cytoplasm	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	nucleus	nucleus	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	20	punct	_	_
28	whereas	whereas	IN	IN	_	35	mark	_	_
29	I	i	NN	NN	_	32	compound	_	_
30	kappa	kappa	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	gamma-2	gamma-2	NN	NN	_	35	nsubj	_	_
33	is	be	VBZ	VBZ	_	35	cop	_	_
34	predominantly	predominantly	RB	RB	_	35	advmod	_	_
35	nuclear	nuclear	JJ	JJ	_	20	advcl	_	_
36	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	I	i	NN	NN	_	6	compound	_	_
3	kappa	kappa	NN	NN	_	6	compound	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	gamma	gamma	NN	NN	_	6	compound	_	_
6	isoforms	isoform	NNS	NNS	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	display	display	VBP	VBP	_	0	root	_	_
9	differences	difference	NNS	NNS	_	8	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	specificity	specificity	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	affinity	affinity	NN	NN	_	11	conj	_	_
14	for	for	IN	IN	_	17	case	_	_
15	Rel/NF-kappa	rel/nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	While	while	IN	IN	_	6	mark	_	_
2	p70I	p70i	NN	NN	_	5	compound	_	_
3	kappa	kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	gamma	gamma	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	29	advcl	_	_
7	p50-	p50-	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	p65-	p65-	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	c-Rel-mediated	c-rel-mediated	JJ	JJ	_	7	conj	_	_
13	transactivation	transactivation	NN	NN	_	7	dep	_	_
14	and/or	and/or	CC	CC	_	13	cc	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	29	punct	_	_
18	both	both	CC	CC	_	22	cc:preconj	_	_
19	I	i	NN	NN	_	22	compound	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	gamma-1	gamma-1	NN	NN	_	29	nsubj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	I	i	NN	NN	_	27	compound	_	_
25	kappa	kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	gamma-2	gamma-2	NN	NN	_	22	conj	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	specific	specific	JJ	JJ	_	0	root	_	_
30	for	for	IN	IN	_	31	case	_	_
31	p50	p50	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	have	have	VBP	VBP	_	29	conj	_	_
34	different	different	JJ	JJ	_	35	amod	_	_
35	affinities	affinity	NNS	NNS	_	33	dobj	_	_
36	for	for	IN	IN	_	38	case	_	_
37	this	this	DT	DT	_	38	det	_	_
38	subunit	subunit	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	28	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	I	i	NN	NN	_	7	compound	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	gamma-1	gamma-1	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	I	i	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	gamma-2	gamma-2	NN	NN	_	7	conj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	protein	protein	NN	NN	_	18	compound	_	_
16	kinase	kinase	NN	NN	_	18	compound	_	_
17	A	a	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	2	nmod	_	_
19	whose	whose	WP$	WP$	_	20	nmod:poss	_	_
20	phosphorylation	phosphorylation	NN	NN	_	21	nsubj	_	_
21	modulates	modulate	VBZ	VBZ	_	18	acl:relcl	_	_
22	p70I	p70i	NN	NN	_	27	compound	_	_
23	kappa	kappa	NN	NN	_	27	compound	_	_
24	B	b	NN	NN	_	27	compound	_	_
25	gamma	gamma	NN	NN	_	27	compound	_	_
26	inhibitory	inhibitory	JJ	JJ	_	27	amod	_	_
27	activity	activity	NN	NN	_	21	dobj	_	_
28	suggests	suggest	VBZ	VBZ	_	0	root	_	_
29	that	that	IN	IN	_	35	mark	_	_
30	alternative	alternative	JJ	JJ	_	32	amod	_	_
31	RNA	rna	NN	NN	_	32	compound	_	_
32	splicing	splicing	NN	NN	_	35	nsubjpass	_	_
33	may	may	MD	MD	_	35	aux	_	_
34	be	be	VB	VB	_	35	auxpass	_	_
35	used	use	VBN	VBN	_	28	ccomp	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	generate	generate	VB	VB	_	35	xcomp	_	_
38	I	i	NN	NN	_	42	compound	_	_
39	kappa	kappa	NN	NN	_	42	compound	_	_
40	B	b	NN	NN	_	42	compound	_	_
41	gamma	gamma	NN	NN	_	42	compound	_	_
42	isoforms	isoform	NNS	NNS	_	37	dobj	_	_
43	that	that	WDT	WDT	_	44	nsubj	_	_
44	respond	respond	VBP	VBP	_	42	acl:relcl	_	_
45	differently	differently	RB	RB	_	44	advmod	_	_
46	to	to	TO	TO	_	48	case	_	_
47	intracellular	intracellular	JJ	JJ	_	48	amod	_	_
48	signals	signal	NNS	NNS	_	44	nmod	_	_
49	.	.	.	.	_	28	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	lymphoblastoid	lymphoblastoid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	low-dose	low-dose	JJ	JJ	_	14	amod	_	_
13	ionizing	ionize	VBG	VBG	_	14	amod	_	_
14	radiation	radiation	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	pleiotropic	pleiotropic	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	0	root	_	_
14	which	which	WDT	WDT	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	13	acl:relcl	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	several	several	JJ	JJ	_	23	amod	_	_
23	specific	specific	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	ionizing	ionize	VBG	VBG	_	6	amod	_	_
6	radiation	radiation	NN	NN	_	14	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	dose	dose	NN	NN	_	10	compound	_	_
10	range	range	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	2-50	2-50	CD	CD	_	13	nummod	_	_
13	Gy	gy	NN	NN	_	10	nmod	_	_
14	results	result	VBZ	VBZ	_	3	ccomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	expression	expression	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	25	case	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	KG-1	kg-1	NN	NN	_	25	compound	_	_
23	myeloid	myeloid	JJ	JJ	_	25	amod	_	_
24	leukemia	leukemia	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	16	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	human	human	JJ	JJ	_	30	amod	_	_
28	B-lymphocyte	b-lymphocyte	NN	NN	_	30	compound	_	_
29	precursor	precursor	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	conj	_	_
31	;	;	:	:	_	3	punct	_	_
32	the	the	DT	DT	_	34	det	_	_
33	precise	precise	JJ	JJ	_	34	amod	_	_
34	mechanism	mechanism	NN	NN	_	42	nsubjpass	_	_
35	involved	involve	VBN	VBN	_	34	acl	_	_
36	and	and	CC	CC	_	34	cc	_	_
37	the	the	DT	DT	_	38	det	_	_
38	significance	significance	NN	NN	_	34	conj	_	_
39	are	be	VBP	VBP	_	42	auxpass	_	_
40	not	not	RB	RB	_	42	neg	_	_
41	yet	yet	RB	RB	_	42	advmod	_	_
42	known	know	VBN	VBN	_	3	parataxis	_	_
43	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	report	report	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	even	even	RB	RB	_	7	advmod	_	_
7	lower	lower	JJR	JJR	_	8	amod	_	_
8	doses	dose	NNS	NNS	_	17	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ionizing	ionize	VBG	VBG	_	11	amod	_	_
11	radiation	radiation	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	0.25-2.0	0.25-2.0	CD	CD	_	14	nummod	_	_
14	Gy	gy	NN	NN	_	8	appos	_	_
15	,	,	,	,	_	8	punct	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	capable	capable	JJ	JJ	_	4	ccomp	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	inducing	induce	VBG	VBG	_	17	advcl	_	_
20	expression	expression	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	29	case	_	_
25	EBV-transformed	ebv-transformed	JJ	JJ	_	29	amod	_	_
26	244B	244b	NN	NN	_	29	compound	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	lymphoblastoid	lymphoblastoid	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	20	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	are	be	VBP	VBP	_	7	cop	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	dose	dose	NN	NN	_	7	compound	_	_
7	range	range	NN	NN	_	0	root	_	_
8	where	where	WRB	WRB	_	14	advmod	_	_
9	the	the	DT	DT	_	10	det	_	_
10	viability	viability	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	remains	remain	VBZ	VBZ	_	7	acl:relcl	_	_
15	very	very	RB	RB	_	16	advmod	_	_
16	high	high	JJ	JJ	_	14	xcomp	_	_
17	.	.	.	.	_	7	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	exposure	exposure	NN	NN	_	23	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	137Cs	137cs	NN	NN	_	6	compound	_	_
5	gamma	gamma	NN	NN	_	6	compound	_	_
6	rays	ray	NNS	NNS	_	2	nmod	_	_
7	at	at	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dose	dose	NN	NN	_	10	compound	_	_
10	rate	rate	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	1.17	1.17	CD	CD	_	13	nummod	_	_
13	Gy/min	gy/min	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	23	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	maximum	maximum	NN	NN	_	23	nsubjpass	_	_
17	in	in	IN	IN	_	18	case	_	_
18	expression	expression	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	seen	see	VBN	VBN	_	0	root	_	_
24	at	at	IN	IN	_	26	case	_	_
25	8	8	CD	CD	_	26	nummod	_	_
26	h	h	NN	NN	_	23	nmod	_	_
27	after	after	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	0.5-Gy	0.5-gy	JJ	JJ	_	30	amod	_	_
30	exposure	exposure	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	Time-course	time-course	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	biphasic	biphasic	JJ	JJ	_	7	amod	_	_
6	time-dependent	time-dependent	JJ	JJ	_	5	dep	_	_
7	expression	expression	NN	NN	_	3	dobj	_	_
8	after	after	IN	IN	_	9	case	_	_
9	0.5-	0.5-	CD	CD	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	1-	1-	CD	CD	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	2-Gy	2-gy	JJ	JJ	_	9	conj	_	_
14	exposures	exposure	NNS	NNS	_	9	dep	_	_
15	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	for	for	IN	IN	_	5	case	_	_
4	each	each	DT	DT	_	5	det	_	_
5	time	time	NN	NN	_	14	nmod	_	_
6	examined	examine	VBN	VBN	_	5	acl	_	_
7	,	,	,	,	_	14	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	maximum	maximum	NN	NN	_	0	root	_	_
15	after	after	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	0.5-Gy	0.5-gy	JJ	JJ	_	18	amod	_	_
18	exposure	exposure	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	p50	p50	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p65	p65	NN	NN	_	5	conj	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	subunits	subunit	NNS	NNS	_	5	dep	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	shown	show	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	13	xcomp	_	_
17	differentially	differentially	RB	RB	_	16	advmod	_	_
18	after	after	IN	IN	_	19	case	_	_
19	exposures	exposure	NNS	NNS	_	16	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	1.0	1.0	CD	CD	_	24	nummod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	2.0	2.0	CD	CD	_	21	conj	_	_
24	Gy	gy	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	antioxidants	antioxidant	NNS	NNS	_	3	nsubj	_	_
3	inhibit	inhibit	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	co-ordinate	co-ordinate	JJ	JJ	_	8	amod	_	_
8	fashion	fashion	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	production	production	NN	NN	_	3	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	tumor	tumor	NN	NN	_	15	compound	_	_
14	necrosis	necrosis	NN	NN	_	15	compound	_	_
15	factor-alpha	factor-alpha	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	IL-beta	il-beta	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	IL-6	il-6	NN	NN	_	15	conj	_	_
21	by	by	IN	IN	_	26	case	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	3	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	antioxidants	antioxidant	NNS	NNS	_	26	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	including	include	VBG	VBG	_	6	case	_	_
5	butylated	butylate	VBN	VBN	_	6	amod	_	_
6	hydroxyanisole	hydroxyanisole	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	BHA	bha	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	tetrahydropapaveroline	tetrahydropapaveroline	NN	NN	_	6	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	THP	thp	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	6	punct	_	_
16	nordihydroguiauretic	nordihydroguiauretic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	6	conj	_	_
18	,	,	,	,	_	6	punct	_	_
19	and	and	CC	CC	_	6	cc	_	_
20	10,11-dihydroxyaporphine	10,11-dihydroxyaporphine	NN	NN	_	6	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	DHA	dha	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	2	punct	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	found	find	VBN	VBN	_	0	root	_	_
27	to	to	TO	TO	_	30	mark	_	_
28	be	be	VB	VB	_	30	cop	_	_
29	potent	potent	JJ	JJ	_	30	amod	_	_
30	inhibitors	inhibitor	NNS	NNS	_	26	xcomp	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	production	production	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	41	case	_	_
35	tumor	tumor	NN	NN	_	41	compound	_	_
36	necrosis	necrosis	NN	NN	_	41	compound	_	_
37	factor	factor	NN	NN	_	41	compound	_	_
38	(	(	-LRB-	-LRB-	_	41	punct	_	_
39	TNF	tnf	NN	NN	_	41	compound	_	_
40	)	)	-RRB-	-RRB-	_	41	punct	_	_
41	-alpha	-alpha	NN	NN	_	33	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	IL-1	il-1	NN	NN	_	44	compound	_	_
44	beta	beta	NN	NN	_	41	conj	_	_
45	,	,	,	,	_	41	punct	_	_
46	and	and	CC	CC	_	41	cc	_	_
47	IL-6	il-6	NN	NN	_	41	conj	_	_
48	by	by	IN	IN	_	53	case	_	_
49	human	human	JJ	JJ	_	53	amod	_	_
50	peripheral	peripheral	JJ	JJ	_	53	amod	_	_
51	blood	blood	NN	NN	_	53	compound	_	_
52	mononuclear	mononuclear	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	30	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	PBMC	pbmc	NN	NN	_	53	appos	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	stimulated	stimulate	VBN	VBN	_	53	acl	_	_
58	by	by	IN	IN	_	59	case	_	_
59	lipopolysaccharide	lipopolysaccharide	NN	NN	_	57	nmod	_	_
60	(	(	-LRB-	-LRB-	_	61	punct	_	_
61	LPS	lps	NN	NN	_	59	appos	_	_
62	)	)	-RRB-	-RRB-	_	61	punct	_	_
63	(	(	-LRB-	-LRB-	_	64	punct	_	_
64	IC50s	ic50s	NN	NN	_	59	appos	_	_
65	in	in	IN	IN	_	69	case	_	_
66	the	the	DT	DT	_	69	det	_	_
67	low	low	JJ	JJ	_	68	amod	_	_
68	micromolar	micromolar	JJ	JJ	_	69	amod	_	_
69	range	range	NN	NN	_	64	nmod	_	_
70	)	)	-RRB-	-RRB-	_	64	punct	_	_
71	.	.	.	.	_	26	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	gene	gene	NN	NN	_	7	nmod:npmod	_	_
7	selective	selective	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	not	not	RB	RB	_	7	conj	_	_
10	due	due	JJ	JJ	_	7	dep	_	_
11	to	to	TO	TO	_	13	case	_	_
12	general	general	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	synthesis	synthesis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Inhibition	inhibition	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	PBMC	pbmc	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	also	also	RB	RB	_	8	advmod	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	other	other	JJ	JJ	_	12	amod	_	_
12	inducers	inducer	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	8	advcl	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	staphylococci	staphylococcus	NNS	NNS	_	8	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	silica	silica	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	zymosan	zymosan	NN	NN	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	16	punct	_	_
22	.	.	.	.	_	8	punct	_	_

1	Much	much	RB	RB	_	2	advmod	_	_
2	higher	higher	JJR	JJR	_	3	amod	_	_
3	concentrations	concentration	NNS	NNS	_	27	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	other	other	JJ	JJ	_	6	amod	_	_
6	antioxidants	antioxidant	NNS	NNS	_	3	nmod	_	_
7	--	--	:	:	_	6	punct	_	_
8	including	include	VBG	VBG	_	10	case	_	_
9	ascorbic	ascorbic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	trolox	trolox	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	alpha-tocopherol	alpha-tocopherol	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	butylated	butylate	VBN	VBN	_	17	amod	_	_
17	hydroxytoluene	hydroxytoluene	NN	NN	_	10	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	5-lipoxygenase	5-lipoxygenase	JJ	JJ	_	23	amod	_	_
22	inhibitor	inhibitor	NN	NN	_	23	compound	_	_
23	zileuton	zileuton	NN	NN	_	10	conj	_	_
24	--	--	:	:	_	27	punct	_	_
25	did	do	VBD	VBD	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	affect	affect	VB	VB	_	0	root	_	_
28	the	the	DT	DT	_	29	det	_	_
29	production	production	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	cytokines	cytokine	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	compounds	compound	NNS	NNS	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	inhibit	inhibit	VB	VB	_	0	root	_	_
7	IL-1-induced	il-1-induced	JJ	JJ	_	8	amod	_	_
8	production	production	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IL-6	il-6	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	showing	show	VBG	VBG	_	6	advcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	selectivity	selectivity	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Antioxidant-mediated	antioxidant-mediated	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cytokine	cytokine	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	correlated	correlated	JJ	JJ	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	corresponding	corresponding	JJ	JJ	_	15	amod	_	_
14	messenger	messenger	NN	NN	_	15	compound	_	_
15	RNAs	rna	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	THP	thp	NN	NN	_	7	nsubj	_	_
7	inhibited	inhibit	VBD	VBD	_	4	ccomp	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	IL-1	il-1	NN	NN	_	13	compound	_	_
12	beta	beta	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	THP	thp	NN	NN	_	2	nsubj	_	_
2	decreased	decrease	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	concentration	concentration	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	8	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	AP-1	ap-1	NN	NN	_	10	conj	_	_
13	detected	detect	VBN	VBN	_	8	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	extracts	extract	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	PBMC	pbmc	NN	NN	_	16	nmod	_	_
19	cultured	culture	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	presence	presence	NN	NN	_	19	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	absence	absence	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	LPS	lps	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	THP	thp	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	DHA	dha	NN	NN	_	1	conj	_	_
4	markedly	markedly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-1	il-1	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	9	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	circulation	circulation	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	mice	mouse	NNS	NNS	_	15	nmod	_	_
18	following	follow	VBG	VBG	_	20	case	_	_
19	LPS	lps	NN	NN	_	20	compound	_	_
20	injection	injection	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	3	advmod	_	_
2	antioxidants	antioxidant	NNS	NNS	_	3	nsubj	_	_
3	vary	vary	VBP	VBP	_	0	root	_	_
4	widely	widely	RB	RB	_	3	advmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	potency	potency	NN	NN	_	3	nmod	_	_
7	as	as	IN	IN	_	8	case	_	_
8	inhibitors	inhibitor	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	transcription	transcription	NN	NN	_	11	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	for	for	IN	IN	_	23	case	_	_
22	pro-inflammatory	pro-inflammatory	JJ	JJ	_	23	amod	_	_
23	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Coordinate	coordinate	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	genes	gene	NNS	NNS	_	5	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
10	cytokines	cytokine	NNS	NNS	_	2	nmod	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	provide	provide	VB	VB	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	strategy	strategy	NN	NN	_	12	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	therapy	therapy	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	diseases	disease	NNS	NNS	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	inflammatory	inflammatory	JJ	JJ	_	21	amod	_	_
21	pathogenesis	pathogenesis	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	for	for	IN	IN	_	25	case	_	_
24	septic	septic	JJ	JJ	_	25	amod	_	_
25	shock	shock	NN	NN	_	18	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	2	nsubj	_	_
2	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	9	amod	_	_
7	colony-stimulating	colony-stimulating	JJ	JJ	_	9	amod	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	:	:	:	:	_	2	punct	_	_
14	involvement	involvement	NN	NN	_	2	dep	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	conserved	conserve	VBN	VBN	_	19	amod	_	_
18	lymphokine	lymphokine	NN	NN	_	19	compound	_	_
19	element	element	NN	NN	_	14	nmod	_	_
20	0	0	CD	CD	_	19	nummod	_	_
21	.	.	.	.	_	14	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	13	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	interleukin-2	interleukin-2	NN	NN	_	3	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-2	il-2	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	produced	produce	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	phorbol-12-myristate	phorbol-12-myristate	NN	NN	_	18	compound	_	_
18	acetate	acetate	NN	NN	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PMA	pma	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	calcium	calcium	NN	NN	_	24	compound	_	_
24	ionophore	ionophore	NN	NN	_	18	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	A23187	a23187	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	in	in	IN	IN	_	34	case	_	_
29	human	human	JJ	JJ	_	34	amod	_	_
30	T	t	NN	NN	_	34	compound	_	_
31	cell	cell	NN	NN	_	34	compound	_	_
32	leukemia	leukemia	NN	NN	_	34	compound	_	_
33	Jurkat	jurkat	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	15	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GM-CSF	gm-csf	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-2	il-2	NN	NN	_	4	conj	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	immunosuppressive	immunosuppressive	JJ	JJ	_	11	amod	_	_
11	drugs	drug	NNS	NNS	_	8	nmod	_	_
12	such	such	JJ	JJ	_	15	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CsA	csa	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	FK506	fk506	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	Earlier	earlier	JJR	JJR	_	2	amod	_	_
2	studies	study	NNS	NNS	_	8	nsubj	_	_
3	on	on	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	IL-2	il-2	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	23	mark	_	_
10	overexpression	overexpression	NN	NN	_	23	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	calcineurin	calcineurin	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	CN	cn	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	12	punct	_	_
17	a	a	DT	DT	_	20	det	_	_
18	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	20	amod	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	phosphatase	phosphatase	NN	NN	_	12	appos	_	_
21	,	,	,	,	_	12	punct	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	stimulate	stimulate	VB	VB	_	8	ccomp	_	_
24	transcription	transcription	NN	NN	_	23	dobj	_	_
25	from	from	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	IL-2	il-2	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	24	nmod	_	_
29	through	through	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	NF-AT-binding	nf-at-binding	JJ	JJ	_	32	amod	_	_
32	site	site	NN	NN	_	23	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	obtained	obtain	VBD	VBD	_	0	root	_	_
7	evidence	evidence	NN	NN	_	6	dobj	_	_
8	that	that	IN	IN	_	27	mark	_	_
9	transfection	transfection	NN	NN	_	27	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cDNAs	cdna	NNS	NNS	_	9	nmod	_	_
13	for	for	IN	IN	_	25	case	_	_
14	CN	cn	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	25	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	catalytic	catalytic	JJ	JJ	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	CN	cn	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	15	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	regulatory	regulatory	JJ	JJ	_	21	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	subunits	subunit	NNS	NNS	_	12	nmod	_	_
26	also	also	RB	RB	_	27	advmod	_	_
27	augments	augment	VBZ	VBZ	_	7	ccomp	_	_
28	transcription	transcription	NN	NN	_	27	dobj	_	_
29	from	from	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	GM-CSF	gm-csf	NN	NN	_	32	compound	_	_
32	promoter	promoter	NN	NN	_	28	nmod	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	recovers	recover	VBZ	VBZ	_	27	conj	_	_
35	the	the	DT	DT	_	36	det	_	_
36	transcription	transcription	NN	NN	_	34	dobj	_	_
37	inhibited	inhibit	VBN	VBN	_	36	acl	_	_
38	by	by	IN	IN	_	39	case	_	_
39	CsA	csa	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	constitutively	constitutively	RB	RB	_	3	advmod	_	_
3	active	active	JJ	JJ	_	4	amod	_	_
4	type	type	NN	NN	_	19	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	CN	cn	NN	NN	_	9	compound	_	_
8	A	a	NN	NN	_	9	compound	_	_
9	subunit	subunit	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	lacks	lack	VBZ	VBZ	_	4	acl:relcl	_	_
13	the	the	DT	DT	_	17	det	_	_
14	auto-inhibitory	auto-inhibitory	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	calmodulin-binding	calmodulin-binding	JJ	JJ	_	14	conj	_	_
17	domains	domain	NNS	NNS	_	12	dobj	_	_
18	,	,	,	,	_	4	punct	_	_
19	acts	act	VBZ	VBZ	_	0	root	_	_
20	in	in	IN	IN	_	21	case	_	_
21	synergy	synergy	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	PMA	pma	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	activate	activate	VB	VB	_	19	xcomp	_	_
26	transcription	transcription	NN	NN	_	25	dobj	_	_
27	from	from	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	GM-CSF	gm-csf	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	CN	cn	NN	NN	_	9	nsubj	_	_
8	partially	partially	RB	RB	_	9	advmod	_	_
9	replaces	replace	VBZ	VBZ	_	3	ccomp	_	_
10	calcium	calcium	NN	NN	_	11	compound	_	_
11	ionophore	ionophore	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	synergy	synergy	NN	NN	_	9	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	PMA	pma	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	9	advcl	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	endogenous	endogenous	JJ	JJ	_	21	amod	_	_
21	GM-CSF	gm-csf	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-2	il-2	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	multimerizing	multimerize	VBG	VBG	_	12	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	GM-CSF	gm-csf	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	found	find	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	27	mark	_	_
14	one	one	CD	CD	_	27	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	target	target	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	14	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	CN	cn	NN	NN	_	22	compound	_	_
22	action	action	NN	NN	_	18	nmod	_	_
23	is	be	VBZ	VBZ	_	27	cop	_	_
24	the	the	DT	DT	_	27	det	_	_
25	conserved	conserve	VBN	VBN	_	27	amod	_	_
26	lymphokine	lymphokine	NN	NN	_	27	compound	_	_
27	element	element	NN	NN	_	12	ccomp	_	_
28	0	0	CD	CD	_	27	nummod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CLE0	cle0	NN	NN	_	27	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	27	punct	_	_
33	located	located	JJ	JJ	_	27	amod	_	_
34	at	at	IN	IN	_	35	case	_	_
35	positions	position	NNS	NNS	_	33	nmod	_	_
36	between	between	IN	IN	_	37	case	_	_
37	-54	-54	CD	CD	_	35	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	-40	-40	CD	CD	_	37	conj	_	_
40	.	.	.	.	_	12	punct	_	_

1	Mobility	mobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CLE0	cle0	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	9	nsubj	_	_
9	has	have	VBZ	VBZ	_	4	ccomp	_	_
10	an	a	DT	DT	_	12	det	_	_
11	AP1-binding	ap1-binding	JJ	JJ	_	12	amod	_	_
12	site	site	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	associated	associate	VBN	VBN	_	9	conj	_	_
16	with	with	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	NF-AT-like	nf-at-like	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	termed	term	VBN	VBN	_	19	acl	_	_
22	NF-CLE0	nf-cle0	NN	NN	_	23	compound	_	_
23	gamma	gamma	NN	NN	_	21	xcomp	_	_
24	.	.	.	.	_	4	punct	_	_

1	NF-CLE0	nf-cle0	NN	NN	_	3	compound	_	_
2	gamma	gamma	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	PMA/A23187	pma/a23187	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	inhibited	inhibit	VBN	VBN	_	5	conj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	treatment	treatment	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	CsA	csa	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CN	cn	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	coordinated	coordinate	VBN	VBN	_	11	amod	_	_
11	induction	induction	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	GM-CSF	gm-csf	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-2	il-2	NN	NN	_	14	conj	_	_
17	genes	gene	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	that	that	IN	IN	_	30	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	CLE0	cle0	NN	NN	_	22	compound	_	_
22	sequence	sequence	NN	NN	_	30	nsubj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	GM-CSF	gm-csf	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	is	be	VBZ	VBZ	_	30	cop	_	_
28	a	a	DT	DT	_	30	det	_	_
29	functional	functional	JJ	JJ	_	30	amod	_	_
30	analogue	analogue	NN	NN	_	7	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	NF-AT-binding	nf-at-binding	JJ	JJ	_	34	amod	_	_
34	site	site	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	IL-2	il-2	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	30	punct	_	_
40	which	which	WDT	WDT	_	41	nsubj	_	_
41	mediates	mediate	VBZ	VBZ	_	30	acl:relcl	_	_
42	signals	signal	NNS	NNS	_	41	dobj	_	_
43	downstream	downstream	RB	RB	_	42	amod	_	_
44	of	of	IN	IN	_	47	case	_	_
45	T	t	NN	NN	_	47	compound	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	activation	activation	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	extracellular	extracellular	JJ	JJ	_	10	amod	_	_
9	matrix	matrix	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	1	nmod	_	_
11	tenascin	tenascin	NN	NN	_	10	dep	_	_
12	.	.	.	.	_	1	punct	_	_

1	Tenascin	tenascin	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	TN	tn	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	an	a	DT	DT	_	9	det	_	_
7	extracellular	extracellular	JJ	JJ	_	9	amod	_	_
8	matrix	matrix	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	9	acl:relcl	_	_
13	widely	widely	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	fetus	fetus	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	sparingly	sparingly	RB	RB	_	21	advmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	adult	adult	NN	NN	_	16	conj	_	_
22	,	,	,	,	_	12	punct	_	_
23	but	but	CC	CC	_	12	cc	_	_
24	reappears	reappear	VBZ	VBZ	_	12	conj	_	_
25	at	at	IN	IN	_	27	case	_	_
26	high	high	JJ	JJ	_	27	amod	_	_
27	levels	level	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	certain	certain	JJ	JJ	_	30	amod	_	_
30	areas	area	NNS	NNS	_	24	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	tissue	tissue	NN	NN	_	33	compound	_	_
33	insult	insult	NN	NN	_	30	nmod	_	_
34	such	such	JJ	JJ	_	37	case	_	_
35	as	as	IN	IN	_	34	mwe	_	_
36	tumor	tumor	NN	NN	_	37	compound	_	_
37	matrices	matrix	NNS	NNS	_	33	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	sites	site	NNS	NNS	_	37	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	wound	wound	NN	NN	_	42	compound	_	_
42	healing	healing	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	soluble	soluble	JJ	JJ	_	6	amod	_	_
6	TN	tn	NN	NN	_	7	nsubj	_	_
7	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
8	proliferation	proliferation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	7	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	alpha	alpha	NN	NN	_	18	compound	_	_
17	CD3	cd3	NN	NN	_	18	compound	_	_
18	Ab	ab	NN	NN	_	14	nmod	_	_
19	co-immobilized	co-immobilize	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	extracellular	extracellular	JJ	JJ	_	24	amod	_	_
23	matrix	matrix	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	nmod	_	_
25	fibronectin	fibronectin	NN	NN	_	24	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	FN	fn	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	2	punct	_	_

1	TN	tn	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	proliferation	proliferation	NN	NN	_	3	dobj	_	_
5	driven	drive	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	CD3/IL-2	cd3/il-2	NN	NN	_	5	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	by	by	IN	IN	_	12	case	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	ester/IL-2	ester/il-2	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	prevents	prevent	VBZ	VBZ	_	3	conj	_	_
17	high	high	JJ	JJ	_	19	amod	_	_
18	level	level	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-2R	il-2r	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TN	tn	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	culture	culture	NN	NN	_	7	compound	_	_
7	medium	medium	NN	NN	_	2	nmod	_	_
8	does	do	VBZ	VBZ	_	11	aux	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	detectably	detectably	RB	RB	_	11	advmod	_	_
11	alter	alter	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	pattern	pattern	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
17	resulting	result	VBG	VBG	_	16	acl	_	_
18	from	from	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	17	nmod	_	_
21	triggering	trigger	VBG	VBG	_	20	acl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	CD3	cd3	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	11	punct	_	_
26	but	but	CC	CC	_	11	cc	_	_
27	at	at	IN	IN	_	30	case	_	_
28	later	later	JJR	JJR	_	30	amod	_	_
29	time	time	NN	NN	_	30	compound	_	_
30	points	point	NNS	NNS	_	11	conj	_	_
31	prevents	prevent	VBZ	VBZ	_	11	dep	_	_
32	the	the	DT	DT	_	33	det	_	_
33	appearance	appearance	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	39	case	_	_
35	functional	functional	JJ	JJ	_	39	amod	_	_
36	NF-AT1	nf-at1	NN	NN	_	39	compound	_	_
37	transcription	transcription	NN	NN	_	39	compound	_	_
38	factor	factor	NN	NN	_	39	compound	_	_
39	complexes	complex	NNS	NNS	_	33	nmod	_	_
40	in	in	IN	IN	_	44	case	_	_
41	T	t	NN	NN	_	44	compound	_	_
42	cell	cell	NN	NN	_	44	compound	_	_
43	nuclear	nuclear	JJ	JJ	_	44	amod	_	_
44	extracts	extract	NNS	NNS	_	31	nmod	_	_
45	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	postulated	postulate	VBN	VBN	_	8	amod	_	_
8	role	role	NN	NN	_	4	nmod	_	_
9	for	for	IN	IN	_	10	case	_	_
10	TN	tn	NN	NN	_	8	nmod	_	_
11	as	as	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	natural	natural	JJ	JJ	_	14	amod	_	_
14	antagonist	antagonist	NN	NN	_	8	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	FN	fn	NN	NN	_	17	compound	_	_
17	action	action	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	suggest	suggest	VBP	VBP	_	4	conj	_	_
21	that	that	IN	IN	_	36	mark	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	responses	response	NNS	NNS	_	36	nsubjpass	_	_
25	occurring	occur	VBG	VBG	_	24	acl	_	_
26	at	at	IN	IN	_	28	case	_	_
27	tissue	tissue	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	which	which	WDT	WDT	_	33	nmod	_	_
31	TN	tn	NN	NN	_	33	nsubjpass	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	expressed	express	VBN	VBN	_	28	acl:relcl	_	_
34	could	could	MD	MD	_	36	aux	_	_
35	be	be	VB	VB	_	36	auxpass	_	_
36	influenced	influence	VBN	VBN	_	20	ccomp	_	_
37	by	by	IN	IN	_	39	case	_	_
38	its	its	PRP$	PRP$	_	39	nmod:poss	_	_
39	presence	presence	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	Central	central	JJ	JJ	_	4	amod	_	_
2	nervous	nervous	JJ	JJ	_	4	amod	_	_
3	system-derived	system-derived	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B-binding	b-binding	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	enhances	enhance	VBZ	VBZ	_	9	acl:relcl	_	_
12	human	human	JJ	JJ	_	17	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
14	virus	virus	NN	NN	_	17	compound	_	_
15	type	type	NN	NN	_	17	compound	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	transcription	transcription	NN	NN	_	11	dobj	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	11	advmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	facilitates	facilitate	VBZ	VBZ	_	11	conj	_	_
22	TAR-independent	tar-independent	JJ	JJ	_	23	amod	_	_
23	transactivation	transactivation	NN	NN	_	21	dobj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	Tat	tat	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tat	tat	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	3	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HIV-1	hiv-1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	potent	potent	JJ	JJ	_	16	amod	_	_
16	activator	activator	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	21	case	_	_
18	long	long	JJ	JJ	_	21	amod	_	_
19	terminal	terminal	JJ	JJ	_	21	amod	_	_
20	repeat-directed	repeat-directed	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	While	while	IN	IN	_	8	mark	_	_
2	in	in	IN	IN	_	5	case	_	_
3	most	most	JJS	JJS	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	types	type	NNS	NNS	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	activation	activation	NN	NN	_	8	nsubj	_	_
8	requires	require	VBZ	VBZ	_	22	advcl	_	_
9	interaction	interaction	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Tat	tat	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	unusual	unusual	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	9	nmod	_	_
17	TAR	tar	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	22	punct	_	_
19	astrocytic	astrocytic	JJ	JJ	_	21	amod	_	_
20	glial	glial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	22	nsubj	_	_
22	support	support	VBP	VBP	_	0	root	_	_
23	TAR-independent	tar-independent	JJ	JJ	_	24	amod	_	_
24	transactivation	transactivation	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
27	transcription	transcription	NN	NN	_	24	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	Tat	tat	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	alternative	alternative	JJ	JJ	_	3	amod	_	_
3	pathway	pathway	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Tat	tat	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	17	det	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	12	appos	_	_
18	capable	capable	JJ	JJ	_	17	amod	_	_
19	of	of	IN	IN	_	20	mark	_	_
20	binding	bind	VBG	VBG	_	18	advcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	prototypical	prototypical	JJ	JJ	_	23	amod	_	_
23	form	form	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	23	nmod	_	_
28	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
29	factor	factor	NN	NN	_	31	compound	_	_
30	kappa	kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	27	dep	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	present	present	JJ	JJ	_	27	amod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	many	many	JJ	JJ	_	40	amod	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	types	type	NNS	NNS	_	36	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	including	include	VBG	VBG	_	44	case	_	_
43	T	t	NN	NN	_	44	compound	_	_
44	lymphocytes	lymphocyte	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	8	punct	_	_

1	Tat	tat	NN	NN	_	2	compound	_	_
2	transactivation	transactivation	NN	NN	_	10	nsubj	_	_
3	mediated	mediate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	sufficient	sufficient	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	allow	allow	VB	VB	_	10	xcomp	_	_
13	replication	replication	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	TAR-deleted	tar-deleted	JJ	JJ	_	17	amod	_	_
16	mutant	mutant	JJ	JJ	_	17	amod	_	_
17	HIV-1	hiv-1	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	astrocytes	astrocyte	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	existence	existence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	B-specific	b-specific	JJ	JJ	_	11	amod	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	6	nmod	_	_
12	present	present	JJ	JJ	_	11	amod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	glial	glial	JJ	JJ	_	16	amod	_	_
16	astrocytes	astrocyte	NNS	NNS	_	12	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	differ	differ	VBP	VBP	_	11	acl:relcl	_	_
19	from	from	IN	IN	_	22	case	_	_
20	prototypical	prototypical	JJ	JJ	_	22	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	novel	novel	JJ	JJ	_	6	amod	_	_
3	astrocyte-derived	astrocyte-derived	JJ	JJ	_	2	dep	_	_
4	kappa	kappa	NN	NN	_	6	compound	_	_
5	B-binding	b-binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	retained	retain	VBN	VBN	_	0	root	_	_
9	on	on	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
12	Tat	tat	NN	NN	_	14	compound	_	_
13	affinity	affinity	NN	NN	_	14	compound	_	_
14	column	column	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	while	while	IN	IN	_	24	mark	_	_
17	prototypical	prototypical	JJ	JJ	_	19	amod	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	24	nsubj	_	_
20	from	from	IN	IN	_	23	case	_	_
21	Jurkat	jurkat	NN	NN	_	23	compound	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	is	be	VBZ	VBZ	_	8	advcl	_	_
25	not	not	RB	RB	_	24	neg	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	astrocyte-derived	astrocyte-derived	JJ	JJ	_	10	amod	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B-binding	b-binding	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	11	nsubj	_	_
11	activate	activate	VBP	VBP	_	5	ccomp	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
16	long	long	JJ	JJ	_	18	amod	_	_
17	terminal	terminal	JJ	JJ	_	18	amod	_	_
18	repeat	repeat	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	that	that	IN	IN	_	24	mark	_	_
21	this	this	DT	DT	_	22	det	_	_
22	activation	activation	NN	NN	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	dependent	dependent	JJ	JJ	_	11	conj	_	_
25	on	on	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	TAR-independent	tar-independent	JJ	JJ	_	4	amod	_	_
4	transactivation	transactivation	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	transcription	transcription	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	reproduced	reproduce	VBN	VBN	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	astrocyte	astrocyte	NN	NN	_	16	compound	_	_
15	factor-dependent	factor-dependent	JJ	JJ	_	16	amod	_	_
16	manner	manner	NN	NN	_	9	nmod	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	correlates	correlate	VBZ	VBZ	_	16	acl:relcl	_	_
19	with	with	IN	IN	_	22	case	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B-binding	b-binding	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	the	the	DT	DT	_	11	det	_	_
5	central	central	JJ	JJ	_	11	amod	_	_
6	nervous	nervous	JJ	JJ	_	11	amod	_	_
7	system-enriched	system-enriched	JJ	JJ	_	11	amod	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	discussed	discuss	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Novel	novel	JJ	JJ	_	3	amod	_	_
2	aldosterone	aldosterone	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	specificity-conferring	specificity-conferring	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dep	_	_
7	at	at	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	level	level	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	membrane	membrane	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	20	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	extra-renal	extra-renal	JJ	JJ	_	7	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	nonepithelial	nonepithelial	JJ	JJ	_	4	dep	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	such	such	JJ	JJ	_	12	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	smooth	smooth	JJ	JJ	_	12	amod	_	_
11	muscle	muscle	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	recently	recently	RB	RB	_	18	advmod	_	_
16	circulating	circulate	VBG	VBG	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	12	conj	_	_
19	have	have	VBP	VBP	_	20	aux	_	_
20	provided	provide	VBN	VBN	_	0	root	_	_
21	increasing	increase	VBG	VBG	_	22	amod	_	_
22	evidence	evidence	NN	NN	_	20	dobj	_	_
23	that	that	IN	IN	_	25	mark	_	_
24	aldosterone	aldosterone	NN	NN	_	25	nsubj	_	_
25	produces	produce	VBZ	VBZ	_	22	ccomp	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	only	only	RB	RB	_	30	cc:preconj	_	_
28	classical	classical	JJ	JJ	_	30	amod	_	_
29	genomic	genomic	JJ	JJ	_	30	amod	_	_
30	effects	effect	NNS	NNS	_	25	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	but	but	CC	CC	_	30	cc	_	_
33	also	also	RB	RB	_	36	advmod	_	_
34	rapid	rapid	JJ	JJ	_	36	amod	_	_
35	non-genomic	non-genomic	JJ	JJ	_	36	amod	_	_
36	effects	effect	NNS	NNS	_	30	conj	_	_
37	on	on	IN	IN	_	40	case	_	_
38	transmembrane	transmembrane	NN	NN	_	40	compound	_	_
39	electrolyte	electrolyte	NN	NN	_	40	compound	_	_
40	movements	movement	NNS	NNS	_	30	nmod	_	_
41	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	involve	involve	VBP	VBP	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	sodium/proton-exchanger	sodium/proton-exchanger	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	membrane	membrane	NN	NN	_	6	nmod	_	_
11	at	at	IN	IN	_	16	case	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	low	low	JJ	JJ	_	16	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	physiological	physiological	JJ	JJ	_	13	dep	_	_
16	concentrations	concentration	NNS	NNS	_	3	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	aldosterone	aldosterone	NN	NN	_	16	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	acute	acute	JJ	JJ	_	22	amod	_	_
22	onset	onset	NN	NN	_	3	nmod	_	_
23	within	within	IN	IN	_	25	case	_	_
24	1-2	1-2	CD	CD	_	25	nummod	_	_
25	minutes	minute	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	second	second	JJ	JJ	_	4	amod	_	_
3	messenger	messenger	NN	NN	_	4	compound	_	_
4	cascade	cascade	NN	NN	_	9	nsubj	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	the	the	DT	DT	_	9	det	_	_
8	inositol-1,4,5-trisphosphate/calcium	inositol-1,4,5-trisphosphate/calcium	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	0	root	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	responds	respond	VBZ	VBZ	_	9	acl:relcl	_	_
12	over	over	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	same	same	JJ	JJ	_	17	amod	_	_
15	rapid	rapid	JJ	JJ	_	17	amod	_	_
16	time	time	NN	NN	_	17	compound	_	_
17	course	course	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	changes	change	NNS	NNS	_	7	nsubjpass	_	_
3	clearly	clearly	RB	RB	_	7	advmod	_	_
4	can	can	MD	MD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	explained	explain	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	genomic	genomic	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	responsible	responsible	JJ	JJ	_	10	acl:relcl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	later	later	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	14	nmod	_	_
18	than	than	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	membrane-related	membrane-related	JJ	JJ	_	22	amod	_	_
21	rapid	rapid	JJ	JJ	_	22	amod	_	_
22	responses	response	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	addition	addition	NN	NN	_	7	dep	_	_
3	to	to	TO	TO	_	7	case	_	_
4	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
5	rapid	rapid	JJ	JJ	_	7	amod	_	_
6	time	time	NN	NN	_	7	compound	_	_
7	course	course	NN	NN	_	18	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	unique	unique	JJ	JJ	_	10	amod	_	_
10	characteristics	characteristic	NNS	NNS	_	18	nsubj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	this	this	DT	DT	_	14	det	_	_
13	new	new	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	10	nmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	steroid	steroid	NN	NN	_	17	compound	_	_
17	action	action	NN	NN	_	14	nmod	_	_
18	include	include	VBP	VBP	_	0	root	_	_
19	a	a	DT	DT	_	21	det	_	_
20	10000-fold	10000-fold	JJ	JJ	_	21	amod	_	_
21	selectivity	selectivity	NN	NN	_	18	dobj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	aldosterone	aldosterone	NN	NN	_	21	nmod	_	_
24	over	over	IN	IN	_	25	case	_	_
25	cortisol	cortisol	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	the	the	DT	DT	_	28	det	_	_
28	ineffectiveness	ineffectiveness	NN	NN	_	21	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	spironolactones	spironolactone	NNS	NNS	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	classical	classical	JJ	JJ	_	34	amod	_	_
33	mineralocorticoid	mineralocorticoid	NN	NN	_	34	compound	_	_
34	antagonists	antagonist	NNS	NNS	_	30	appos	_	_
35	,	,	,	,	_	30	punct	_	_
36	as	as	IN	IN	_	37	case	_	_
37	antagonists	antagonist	NNS	NNS	_	28	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	response	response	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	18	punct	_	_

1	Subsequently	subsequently	RB	RB	_	2	advmod	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	sites	site	NNS	NNS	_	6	nsubjpass	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	plasma	plasma	NN	NN	_	10	compound	_	_
10	membrane	membrane	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	show	show	VBP	VBP	_	6	ccomp	_	_
16	pharmacological	pharmacological	JJ	JJ	_	15	dobj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	aldosterone	aldosterone	NN	NN	_	19	compound	_	_
19	specificity	specificity	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	kinetic	kinetic	JJ	JJ	_	16	conj	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	high	high	JJ	JJ	_	25	amod	_	_
25	turnover	turnover	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	properties	property	NNS	NNS	_	16	dep	_	_
28	identical	identical	JJ	JJ	_	16	amod	_	_
29	with	with	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	28	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	rapid	rapid	JJ	JJ	_	35	amod	_	_
34	aldosterone	aldosterone	NN	NN	_	35	compound	_	_
35	effects	effect	NNS	NNS	_	30	nmod	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	same	same	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	6	punct	_	_

1	SDS-PAGE	sds-page	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	has	have	VBZ	VBZ	_	8	aux	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	weight	weight	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	approximately	approximately	RB	RB	_	14	advmod	_	_
14	50	50	CD	CD	_	15	nummod	_	_
15	kD	kd	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	paper	paper	NN	NN	_	4	nsubj	_	_
4	reviews	review	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	data	datum	NNS	NNS	_	4	dobj	_	_
7	supporting	support	VBG	VBG	_	6	acl	_	_
8	a	a	DT	DT	_	12	det	_	_
9	new	new	JJ	JJ	_	12	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	two-step	two-step	JJ	JJ	_	9	dep	_	_
12	model	model	NN	NN	_	7	dobj	_	_
13	for	for	IN	IN	_	18	case	_	_
14	non-genomic	non-genomic	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	genomic	genomic	JJ	JJ	_	14	conj	_	_
17	aldosterone	aldosterone	NN	NN	_	18	compound	_	_
18	effects	effect	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	specificity-conferring	specificity-conferring	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	3	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	mineralocorticoid	mineralocorticoid	NN	NN	_	10	compound	_	_
10	action	action	NN	NN	_	7	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	intricate	intricate	JJ	JJ	_	3	amod	_	_
3	arrangement	arrangement	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sites	site	NNS	NNS	_	3	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Ets	ets	NN	NN	_	10	compound	_	_
10	family	family	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	regulates	regulate	VBZ	VBZ	_	0	root	_	_
15	activity	activity	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	alpha	alpha	NN	NN	_	22	compound	_	_
19	4	4	CD	CD	_	22	nummod	_	_
20	integrin	integrin	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	alpha	alpha	NN	NN	_	3	compound	_	_
2	4	4	CD	CD	_	3	nummod	_	_
3	integrins	integrin	NNS	NNS	_	4	nsubj	_	_
4	mediate	mediate	VBP	VBP	_	0	root	_	_
5	cell-cell	cell-cell	JJ	JJ	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cell-extracellular	cell-extracellular	JJ	JJ	_	5	conj	_	_
8	matrix	matrix	NN	NN	_	9	compound	_	_
9	interactions	interaction	NNS	NNS	_	5	dep	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	critical	critical	JJ	JJ	_	5	acl:relcl	_	_
13	for	for	IN	IN	_	14	case	_	_
14	maturation	maturation	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	function	function	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	immune	immune	JJ	JJ	_	20	amod	_	_
20	system	system	NN	NN	_	14	nmod	_	_
21	as	as	RB	RB	_	14	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	differentiation	differentiation	NN	NN	_	14	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	skeletal	skeletal	JJ	JJ	_	27	amod	_	_
27	muscle	muscle	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	examine	examine	VBP	VBP	_	0	root	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
6	controlling	control	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	pattern	pattern	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	4	4	CD	CD	_	12	nummod	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	constructs	construct	NNS	NNS	_	2	nmod	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	5'	5'	JJ	JJ	_	8	amod	_	_
7	deletion	deletion	NN	NN	_	8	compound	_	_
8	mutants	mutant	NNS	NNS	_	5	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	alpha	alpha	NN	NN	_	14	compound	_	_
12	4	4	CD	CD	_	14	nummod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	8	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	compared	compare	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	transfection	transfection	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	16	nmod	_	_
20	into	into	IN	IN	_	22	case	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	express	express	VBP	VBP	_	22	acl:relcl	_	_
25	alpha	alpha	NN	NN	_	24	dobj	_	_
26	4	4	CD	CD	_	25	nummod	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	22	conj	_	_
30	that	that	WDT	WDT	_	31	nsubj	_	_
31	do	do	VBP	VBP	_	29	acl:relcl	_	_
32	not	not	RB	RB	_	31	neg	_	_
33	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	14	nsubjpass	_	_
3	between	between	IN	IN	_	4	case	_	_
4	position	position	NN	NN	_	2	nmod	_	_
5	-42	-42	CD	CD	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	-76	-76	CD	CD	_	5	conj	_	_
8	base	base	NN	NN	_	9	compound	_	_
9	pairs	pair	NNS	NNS	_	4	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	bp	bp	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	0	root	_	_
15	for	for	IN	IN	_	17	case	_	_
16	efficient	efficient	JJ	JJ	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	express	express	VBP	VBP	_	19	acl:relcl	_	_
22	alpha	alpha	NN	NN	_	21	dobj	_	_
23	4	4	CD	CD	_	22	nummod	_	_
24	,	,	,	,	_	14	punct	_	_
25	but	but	CC	CC	_	14	cc	_	_
26	it	it	PRP	PRP	_	27	nsubj	_	_
27	showed	show	VBD	VBD	_	14	conj	_	_
28	no	no	DT	DT	_	29	neg	_	_
29	activity	activity	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	HeLa	hela	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	which	which	WDT	WDT	_	37	nsubj	_	_
35	do	do	VBP	VBP	_	37	aux	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	express	express	VB	VB	_	32	acl:relcl	_	_
38	alpha	alpha	NN	NN	_	37	dobj	_	_
39	4	4	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	14	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	sites	site	NNS	NNS	_	12	nsubjpass	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Ets	ets	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	found	find	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	region	region	NN	NN	_	12	nmod	_	_
16	:	:	:	:	_	12	punct	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	adjacent	adjacent	JJ	JJ	_	19	amod	_	_
19	sites	site	NNS	NNS	_	12	dep	_	_
20	at	at	IN	IN	_	21	case	_	_
21	positions	position	NNS	NNS	_	19	nmod	_	_
22	-50	-50	CD	CD	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	-54	-54	CD	CD	_	22	conj	_	_
25	bp	bp	NN	NN	_	21	dep	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	a	a	DT	DT	_	30	det	_	_
28	more	more	RBR	RBR	_	30	advmod	_	_
29	5'	5'	JJ	JJ	_	30	amod	_	_
30	site	site	NN	NN	_	19	conj	_	_
31	at	at	IN	IN	_	32	case	_	_
32	position	position	NN	NN	_	30	nmod	_	_
33	-67	-67	CD	CD	_	34	nummod	_	_
34	bp	bp	NN	NN	_	32	dep	_	_
35	.	.	.	.	_	12	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	3	det	_	_
3	series	series	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	constructs	construct	NNS	NNS	_	3	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	deletions	deletion	NNS	NNS	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	mutations	mutation	NNS	NNS	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	found	find	VBD	VBD	_	1	parataxis	_	_
16	that	that	IN	IN	_	22	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	3'-most	3'-most	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	22	nsubj	_	_
20	alone	alone	RB	RB	_	19	advmod	_	_
21	was	be	VBD	VBD	_	22	cop	_	_
22	sufficient	sufficient	JJ	JJ	_	15	ccomp	_	_
23	for	for	IN	IN	_	24	mark	_	_
24	binding	bind	VBG	VBG	_	22	nmod	_	_
25	GA-binding	ga-binding	JJ	JJ	_	27	amod	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	24	dobj	_	_
28	(	(	-LRB-	-LRB-	_	27	punct	_	_
29	GABP	gabp	NN	NN	_	33	compound	_	_
30	alpha	alpha	NN	NN	_	33	compound	_	_
31	)	)	-RRB-	-RRB-	_	33	punct	_	_
32	/GABP	/gabp	NN	NN	_	33	compound	_	_
33	beta	beta	NN	NN	_	27	dep	_	_
34	and	and	CC	CC	_	24	cc	_	_
35	for	for	IN	IN	_	38	case	_	_
36	a	a	DT	DT	_	38	det	_	_
37	low	low	JJ	JJ	_	38	amod	_	_
38	level	level	NN	NN	_	24	conj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	transcriptional	transcriptional	JJ	JJ	_	41	amod	_	_
41	activation	activation	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	1	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	all	all	DT	DT	_	4	det	_	_
3	three	three	CD	CD	_	4	nummod	_	_
4	sites	site	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	present	present	JJ	JJ	_	14	advcl	_	_
7	,	,	,	,	_	14	punct	_	_
8	a	a	DT	DT	_	12	det	_	_
9	second	second	JJ	JJ	_	12	amod	_	_
10	complex	complex	NN	NN	_	12	compound	_	_
11	``	``	``	``	_	12	punct	_	_
12	a	a	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	contains	contain	VBZ	VBZ	_	14	dep	_	_
18	an	a	DT	DT	_	20	det	_	_
19	unknown	unknown	JJ	JJ	_	20	amod	_	_
20	member	member	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Ets	ets	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Formation	formation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	complex	complex	JJ	JJ	_	4	amod	_	_
4	a	a	NN	NN	_	1	nmod	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	cell-type	cell-type	NN	NN	_	7	nmod:npmod	_	_
7	specific	specific	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	correlated	correlate	VBD	VBD	_	7	conj	_	_
10	with	with	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	high	high	JJ	JJ	_	13	amod	_	_
13	level	level	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Deletion	deletion	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	5'-most	5'-most	JJ	JJ	_	6	amod	_	_
5	Ets	ets	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	1	nmod	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	no	no	DT	DT	_	9	neg	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	11	case	_	_
11	binding	binding	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	GABP	gabp	NN	NN	_	15	compound	_	_
14	alpha/GABP	alpha/gabp	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	but	but	CC	CC	_	7	cc	_	_
18	it	it	PRP	PRP	_	19	nsubj	_	_
19	eliminated	eliminate	VBD	VBD	_	7	conj	_	_
20	a	a	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Concomitant	concomitant	JJ	JJ	_	14	dep	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	loss	loss	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	a	a	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	a	a	DT	DT	_	11	det	_	_
9	new	new	JJ	JJ	_	11	amod	_	_
10	Ets-1-containing	ets-1-containing	JJ	JJ	_	11	amod	_	_
11	complex	complex	NN	NN	_	14	nsubj	_	_
12	``	``	``	``	_	11	punct	_	_
13	c	c	NN	NN	_	11	dep	_	_
14	appeared	appear	VBD	VBD	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Complex	complex	NN	NN	_	2	compound	_	_
2	c	c	NN	NN	_	3	nsubj	_	_
3	substituted	substitute	VBD	VBD	_	0	root	_	_
4	efficiently	efficiently	RB	RB	_	3	advmod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	complex	complex	NN	NN	_	7	compound	_	_
7	a	a	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	although	although	IN	IN	_	13	mark	_	_
5	neither	neither	DT	DT	_	13	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	5'-most	5'-most	JJ	JJ	_	11	amod	_	_
10	Ets	ets	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	5	nmod	_	_
12	alone	alone	RB	RB	_	13	advmod	_	_
13	binds	bind	VBZ	VBZ	_	18	advcl	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	18	punct	_	_
17	they	they	PRP	PRP	_	18	nsubj	_	_
18	appear	appear	VBP	VBP	_	2	ccomp	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	act	act	VB	VB	_	18	xcomp	_	_
21	as	as	IN	IN	_	22	case	_	_
22	modulators	modulator	NNS	NNS	_	20	nmod	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	control	control	VBP	VBP	_	22	acl:relcl	_	_
25	the	the	DT	DT	_	26	det	_	_
26	pattern	pattern	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	Ets	ets	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	26	nmod	_	_
30	that	that	WDT	WDT	_	31	nsubj	_	_
31	bind	bind	VBP	VBP	_	29	acl:relcl	_	_
32	the	the	DT	DT	_	36	det	_	_
33	alpha	alpha	NN	NN	_	36	compound	_	_
34	4	4	CD	CD	_	36	nummod	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	31	dobj	_	_
37	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	arrangement	arrangement	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Ets	ets	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	coupled	couple	VBN	VBN	_	2	acl	_	_
8	with	with	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	tissue-	tissue-	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	developmental-	developmental-	JJ	JJ	_	10	conj	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	10	dep	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Ets	ets	NN	NN	_	17	compound	_	_
17	members	member	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	likely	likely	RB	RB	_	20	advmod	_	_
20	play	play	VBP	VBP	_	0	root	_	_
21	a	a	DT	DT	_	23	det	_	_
22	key	key	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	25	mark	_	_
25	defining	define	VBG	VBG	_	20	advcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	pattern	pattern	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	alpha	alpha	NN	NN	_	31	compound	_	_
30	4	4	CD	CD	_	31	nummod	_	_
31	integrin	integrin	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	20	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	tissue	tissue	NN	NN	_	7	compound	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	binding	binding	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	c-Rel/p65	c-rel/p65	NN	NN	_	17	compound	_	_
17	heterodimers	heterodimer	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B-like	b-like	JJ	JJ	_	22	amod	_	_
22	site	site	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Exposure	exposure	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	monocytic	monocytic	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	bacterial	bacterial	JJ	JJ	_	7	amod	_	_
7	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	LPS	lps	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	activates	activate	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	15	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B/Rel	b/rel	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	11	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	proteins	protein	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	leads	lead	VBZ	VBZ	_	11	conj	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	rapid	rapid	JJ	JJ	_	23	amod	_	_
23	induction	induction	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	products	product	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	including	include	VBG	VBG	_	31	case	_	_
30	tissue	tissue	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TF	tf	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	11	punct	_	_

1	TF	tf	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	the	the	DT	DT	_	6	det	_	_
4	primary	primary	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	initiator	initiator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	coagulation	coagulation	NN	NN	_	11	compound	_	_
10	protease	protease	NN	NN	_	11	compound	_	_
11	cascades	cascade	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	characterization	characterization	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	complex	complex	NN	NN	_	5	nmod	_	_
10	from	from	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	bound	bind	VBD	VBD	_	13	acl:relcl	_	_
16	to	to	TO	TO	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	kappa	kappa	NN	NN	_	20	compound	_	_
19	B-like	b-like	JJ	JJ	_	20	amod	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	5'-CGGAGTTTCC-3'	5'-cggagtttcc-3'	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	20	punct	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	5'-flanking	5'-flanking	JJ	JJ	_	27	amod	_	_
27	region	region	NN	NN	_	20	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	TF	tf	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	activated	activate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	LPS	lps	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	kinetics	kinetics	NNS	NNS	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	preceded	precede	VBD	VBD	_	9	acl:relcl	_	_
12	induction	induction	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	TF	tf	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	TF	tf	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	10	nsubj	_	_
10	bound	bind	VBD	VBD	_	5	ccomp	_	_
11	translated	translate	VBN	VBN	_	12	amod	_	_
12	c-Rel	c-rel	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	p65	p65	NN	NN	_	12	conj	_	_
15	homodimers	homodimer	NNS	NNS	_	12	dep	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	12	cc	_	_
18	p50/p65	p50/p65	NN	NN	_	19	compound	_	_
19	heterodimers	heterodimer	NNS	NNS	_	12	conj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	p50	p50	NN	NN	_	22	compound	_	_
22	homodimers	homodimer	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Base-pair	base-pair	JJ	JJ	_	2	amod	_	_
2	substitutions	substitution	NNS	NNS	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TF	tf	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	indicated	indicate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	17	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	cytosine	cytosine	NN	NN	_	10	nmod	_	_
14	at	at	IN	IN	_	15	case	_	_
15	position	position	NN	NN	_	10	nmod	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	precluded	preclude	VBD	VBD	_	7	ccomp	_	_
18	binding	binding	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	under	under	IN	IN	_	6	case	_	_
5	low-ionic-strength	low-ionic-strength	JJ	JJ	_	6	amod	_	_
6	conditions	condition	NNS	NNS	_	13	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	TF	tf	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	13	nsubj	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	migrate	migrate	VB	VB	_	0	root	_	_
14	with	with	IN	IN	_	17	case	_	_
15	translated	translate	VBN	VBN	_	17	amod	_	_
16	p50/p65	p50/p65	NN	NN	_	17	compound	_	_
17	dimers	dimer	NNS	NNS	_	13	nmod	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	instead	instead	RB	RB	_	20	advmod	_	_
20	comigrated	comigrate	VBD	VBD	_	13	conj	_	_
21	with	with	IN	IN	_	23	case	_	_
22	c-Rel/p65	c-rel/p65	NN	NN	_	23	compound	_	_
23	dimers	dimer	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	13	nsubj	_	_
2	against	against	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Rel	rel	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	conj	_	_
9	and	and	CC	CC	_	1	cc	_	_
10	UV	uv	NN	NN	_	12	compound	_	_
11	cross-linking	cross-linking	JJ	JJ	_	12	amod	_	_
12	studies	study	NNS	NNS	_	1	conj	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	c-Rel	c-rel	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	p65	p65	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	absence	absence	NN	NN	_	15	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p50	p50	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	TF	tf	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	15	nmod	_	_
29	and	and	CC	CC	_	13	cc	_	_
30	further	further	RB	RB	_	31	advmod	_	_
31	showed	show	VBD	VBD	_	13	conj	_	_
32	that	that	IN	IN	_	36	mark	_	_
33	c-Rel/p65	c-rel/p65	NN	NN	_	34	compound	_	_
34	heterodimers	heterodimer	NNS	NNS	_	36	nsubj	_	_
35	selectively	selectively	RB	RB	_	36	advmod	_	_
36	bound	bind	VBD	VBD	_	31	ccomp	_	_
37	to	to	TO	TO	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	TF	tf	NN	NN	_	42	compound	_	_
40	kappa	kappa	NN	NN	_	42	compound	_	_
41	B-like	b-like	JJ	JJ	_	42	amod	_	_
42	site	site	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	13	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TF	tf	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	8	nsubj	_	_
8	conferred	confer	VBD	VBD	_	3	ccomp	_	_
9	LPS	lps	NN	NN	_	10	compound	_	_
10	inducibility	inducibility	NN	NN	_	8	dobj	_	_
11	on	on	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	heterologous	heterologous	JJ	JJ	_	14	amod	_	_
14	promoter	promoter	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	transactivated	transactivate	VBN	VBN	_	8	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	c-Rel	c-rel	NN	NN	_	17	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	p65	p65	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	1	parataxis	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	binding	binding	NN	NN	_	18	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	c-Rel/p65	c-rel/p65	NN	NN	_	11	compound	_	_
11	heterodimers	heterodimer	NNS	NNS	_	8	nmod	_	_
12	to	to	TO	TO	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	novel	novel	JJ	JJ	_	17	amod	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B-like	b-like	JJ	JJ	_	17	amod	_	_
17	site	site	NN	NN	_	8	nmod	_	_
18	mediated	mediate	VBD	VBD	_	6	ccomp	_	_
19	LPS	lps	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	TF	tf	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	monocytic	monocytic	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	20	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	interleukin-13	interleukin-13	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	interleukin-4-dependent	interleukin-4-dependent	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	NF-IL4	nf-il4	NN	NN	_	7	dep	_	_
9	sharing	share	VBG	VBG	_	7	acl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	motif	motif	NN	NN	_	9	dobj	_	_
14	with	with	IN	IN	_	19	case	_	_
15	an	a	DT	DT	_	19	det	_	_
16	interferon-gamma-induced	interferon-gamma-induced	JJ	JJ	_	19	amod	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	binding	bind	VBG	VBG	_	19	amod	_	_
19	factor	factor	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin-13	interleukin-13	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IL-13	il-13	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	interleukin-4	interleukin-4	NN	NN	_	4	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-4	il-4	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	on	on	IN	IN	_	15	case	_	_
14	cellular	cellular	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	2	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	shown	show	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	21	mark	_	_
19	be	be	VB	VB	_	21	cop	_	_
20	quite	quite	RB	RB	_	21	advmod	_	_
21	similar	similar	JJ	JJ	_	17	xcomp	_	_
22	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
7	as	as	RB	RB	_	6	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	6	conj	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	IL-4	il-4	NN	NN	_	17	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-13	il-13	NN	NN	_	14	conj	_	_
17	activate	activate	VBP	VBP	_	3	ccomp	_	_
18	the	the	DT	DT	_	23	det	_	_
19	same	same	JJ	JJ	_	21	dep	_	_
20	recently	recently	RB	RB	_	21	advmod	_	_
21	identified	identify	VBN	VBN	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	17	dobj	_	_
24	NF-IL4	nf-il4	NN	NN	_	23	dep	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	binds	bind	VBZ	VBZ	_	23	acl:relcl	_	_
27	to	to	TO	TO	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	specific	specific	JJ	JJ	_	32	amod	_	_
30	responsive	responsive	JJ	JJ	_	32	amod	_	_
31	element	element	NN	NN	_	32	compound	_	_
32	IL-4RE	il-4re	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	a	a	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	14	nsubj	_	_
10	activated	activate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	interferon-gamma	interferon-gamma	NN	NN	_	10	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	interacts	interact	VBZ	VBZ	_	5	ccomp	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	IL-4RE	il-4re	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	differs	differ	VBZ	VBZ	_	0	root	_	_
3	from	from	IN	IN	_	4	case	_	_
4	NF-IL4	nf-il4	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
8	mobility	mobility	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	complex	complex	NN	NN	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	DNA	dna	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	in	in	IN	IN	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	specificity	specificity	NN	NN	_	8	conj	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	proteins	protein	NNS	NNS	_	8	conj	_	_
23	interacting	interact	VBG	VBG	_	22	acl	_	_
24	with	with	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	DNA	dna	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Sensitivity	sensitivity	NN	NN	_	6	nsubj	_	_
2	against	against	IN	IN	_	5	case	_	_
3	various	various	JJ	JJ	_	5	amod	_	_
4	enzyme	enzyme	NN	NN	_	5	compound	_	_
5	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	components	component	NNS	NNS	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	signal	signal	NN	NN	_	13	compound	_	_
12	transduction	transduction	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	shared	share	VBN	VBN	_	6	ccomp	_	_
16	by	by	IN	IN	_	19	case	_	_
17	all	all	DT	DT	_	19	det	_	_
18	three	three	CD	CD	_	19	nummod	_	_
19	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Prenatal	prenatal	JJ	JJ	_	3	amod	_	_
2	immune	immune	JJ	JJ	_	3	amod	_	_
3	challenge	challenge	NN	NN	_	4	nsubj	_	_
4	alters	alter	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	hypothalamic-pituitary-adrenocortical	hypothalamic-pituitary-adrenocortical	JJ	JJ	_	7	amod	_	_
7	axis	axis	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	adult	adult	JJ	JJ	_	10	amod	_	_
10	rats	rat	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	non-abortive	non-abortive	JJ	JJ	_	6	amod	_	_
5	maternal	maternal	JJ	JJ	_	4	dep	_	_
6	infections	infection	NNS	NNS	_	8	nsubj	_	_
7	would	would	MD	MD	_	8	aux	_	_
8	compromise	compromise	VB	VB	_	2	ccomp	_	_
9	fetal	fetal	JJ	JJ	_	11	amod	_	_
10	brain	brain	NN	NN	_	11	compound	_	_
11	development	development	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	alter	alter	VB	VB	_	8	conj	_	_
14	hypothalamic-pituitary-adrenocortical	hypothalamic-pituitary-adrenocortical	JJ	JJ	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HPA	hpa	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	axis	axis	NN	NN	_	13	dobj	_	_
19	functioning	function	VBG	VBG	_	18	acl	_	_
20	when	when	WRB	WRB	_	21	advmod	_	_
21	adult	adult	JJ	JJ	_	19	advcl	_	_
22	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	putative	putative	JJ	JJ	_	4	amod	_	_
4	teratogenic	teratogenic	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	cell-mediated	cell-mediated	JJ	JJ	_	11	amod	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	5	nmod	_	_
12	versus	versus	CC	CC	_	11	cc	_	_
13	an	a	DT	DT	_	15	det	_	_
14	endotoxic	endotoxic	JJ	JJ	_	15	amod	_	_
15	challenge	challenge	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	10-d-pregnant	10-d-pregnant	JJ	JJ	_	18	amod	_	_
18	rats	rat	NNS	NNS	_	2	parataxis	_	_
19	received	receive	VBD	VBD	_	18	acl	_	_
20	a	a	DT	DT	_	23	det	_	_
21	single	single	JJ	JJ	_	22	amod	_	_
22	intraperitoneal	intraperitoneal	JJ	JJ	_	23	amod	_	_
23	injection	injection	NN	NN	_	19	dobj	_	_
24	of	of	IN	IN	_	31	case	_	_
25	5	5	CD	CD	_	31	nummod	_	_
26	x	x	CC	CC	_	25	cc	_	_
27	10(8)	10(8)	CD	CD	_	25	conj	_	_
28	human	human	JJ	JJ	_	31	amod	_	_
29	red	red	JJ	JJ	_	31	amod	_	_
30	blood	blood	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	23	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	HRBC	hrbc	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	or	or	CC	CC	_	31	cc	_	_
36	gram-negative	gram-negative	JJ	JJ	_	37	amod	_	_
37	bacterial	bacterial	JJ	JJ	_	38	amod	_	_
38	endotoxin	endotoxin	NN	NN	_	31	conj	_	_
39	(	(	-LRB-	-LRB-	_	42	punct	_	_
40	Escherichia	escherichia	FW	FW	_	42	amod	_	_
41	coli	coli	FW	FW	_	40	dep	_	_
42	LPS	lps	NN	NN	_	38	dep	_	_
43	:	:	:	:	_	42	punct	_	_
44	30	30	CD	CD	_	45	nummod	_	_
45	micrograms/kg	micrograms/kg	NNS	NNS	_	42	dep	_	_
46	)	)	-RRB-	-RRB-	_	42	punct	_	_
47	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	adult	adult	JJ	JJ	_	3	amod	_	_
3	male	male	JJ	JJ	_	4	amod	_	_
4	progeny	progeny	NN	NN	_	14	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	3	3	CD	CD	_	7	nummod	_	_
7	mo	mo	NN	NN	_	8	nmod:npmod	_	_
8	old	old	JJ	JJ	_	4	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	13	case	_	_
11	both	both	DT	DT	_	13	det	_	_
12	experimental	experimental	JJ	JJ	_	13	amod	_	_
13	groups	group	NNS	NNS	_	4	nmod	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	increased	increase	VBN	VBN	_	19	amod	_	_
16	basal	basal	JJ	JJ	_	19	amod	_	_
17	plasma	plasma	NN	NN	_	19	compound	_	_
18	corticosterone	corticosterone	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	14	dobj	_	_
20	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	after	after	IN	IN	_	6	case	_	_
5	novelty	novelty	NN	NN	_	6	compound	_	_
6	stress	stress	NN	NN	_	17	nmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	HRBC	hrbc	NN	NN	_	9	compound	_	_
9	group	group	NN	NN	_	17	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	LPS	lps	NN	NN	_	15	compound	_	_
15	group	group	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	increased	increase	VBN	VBN	_	19	amod	_	_
19	ACTH	acth	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	corticosterone	corticosterone	NN	NN	_	19	conj	_	_
22	levels	level	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	17	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	groups	group	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	substantial	substantial	JJ	JJ	_	5	amod	_	_
5	decreases	decrease	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	mineralocorticoid	mineralocorticoid	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MR	mr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	7	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GR	gr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	levels	level	NNS	NNS	_	7	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	hippocampus	hippocampus	NN	NN	_	7	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	25	det	_	_
23	limbic	limbic	JJ	JJ	_	25	amod	_	_
24	brain	brain	NN	NN	_	25	compound	_	_
25	structure	structure	NN	NN	_	20	appos	_	_
26	critical	critical	JJ	JJ	_	25	amod	_	_
27	for	for	IN	IN	_	30	case	_	_
28	HPA	hpa	NN	NN	_	30	compound	_	_
29	axis	axis	NN	NN	_	30	compound	_	_
30	regulation	regulation	NN	NN	_	26	nmod	_	_
31	,	,	,	,	_	3	punct	_	_
32	whereas	whereas	IN	IN	_	39	mark	_	_
33	GR	gr	NN	NN	_	34	compound	_	_
34	concentrations	concentration	NNS	NNS	_	39	nsubj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	hypothalamus	hypothalamus	NN	NN	_	34	nmod	_	_
38	were	be	VBD	VBD	_	39	cop	_	_
39	unchanged	unchanged	JJ	JJ	_	3	advcl	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	in	in	IN	IN	_	43	case	_	_
42	anterior	anterior	JJ	JJ	_	43	amod	_	_
43	pituitary	pituitary	NN	NN	_	46	nsubjpass	_	_
44	were	be	VBD	VBD	_	46	auxpass	_	_
45	slightly	slightly	RB	RB	_	46	advmod	_	_
46	increased	increase	VBN	VBN	_	39	conj	_	_
47	.	.	.	.	_	3	punct	_	_

1	HRBC	hrbc	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	LPS	lps	NN	NN	_	1	conj	_	_
4	indeed	indeed	RB	RB	_	5	advmod	_	_
5	stimulated	stimulate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	maternal	maternal	JJ	JJ	_	9	amod	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	5	dobj	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	revealed	reveal	VBN	VBN	_	5	advcl	_	_
12	by	by	IN	IN	_	16	case	_	_
13	specific	specific	JJ	JJ	_	16	amod	_	_
14	anti-HRBC	anti-hrbc	JJ	JJ	_	16	amod	_	_
15	antibody	antibody	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	enhanced	enhance	VBD	VBD	_	5	conj	_	_
19	IL-1	il-1	NN	NN	_	22	compound	_	_
20	beta	beta	NN	NN	_	22	compound	_	_
21	mRNA	mrna	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	splenocytes	splenocyte	NNS	NNS	_	22	nmod	_	_
25	,	,	,	,	_	18	punct	_	_
26	respectively	respectively	RB	RB	_	18	advmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	a	a	DT	DT	_	9	det	_	_
6	T	t	NN	NN	_	9	compound	_	_
7	cell-mediated	cell-mediated	JJ	JJ	_	9	amod	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	19	nsubj	_	_
10	as	as	RB	RB	_	9	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	an	a	DT	DT	_	15	det	_	_
14	endotoxic	endotoxic	JJ	JJ	_	15	amod	_	_
15	challenge	challenge	NN	NN	_	9	conj	_	_
16	during	during	IN	IN	_	17	case	_	_
17	pregnancy	pregnancy	NN	NN	_	15	nmod	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	induce	induce	VB	VB	_	3	ccomp	_	_
20	anomalies	anomaly	NNS	NNS	_	19	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	HPA	hpa	NN	NN	_	24	compound	_	_
23	axis	axis	NN	NN	_	24	compound	_	_
24	function	function	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	adulthood	adulthood	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Clinically	clinically	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubjpass	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	postulated	postulate	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	disturbed	disturbed	JJ	JJ	_	11	amod	_	_
9	fetal	fetal	JJ	JJ	_	11	amod	_	_
10	brain	brain	NN	NN	_	11	compound	_	_
11	development	development	NN	NN	_	17	nsubj	_	_
12	due	due	JJ	JJ	_	11	amod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	prenatal	prenatal	JJ	JJ	_	16	amod	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	challenge	challenge	NN	NN	_	12	nmod	_	_
17	increases	increase	VBZ	VBZ	_	6	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	vulnerability	vulnerability	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	develop	develop	VB	VB	_	19	acl	_	_
22	mental	mental	JJ	JJ	_	23	amod	_	_
23	illness	illness	NN	NN	_	21	dobj	_	_
24	involving	involve	VBG	VBG	_	23	acl	_	_
25	inadequate	inadequate	JJ	JJ	_	26	amod	_	_
26	responses	response	NNS	NNS	_	24	dobj	_	_
27	to	to	TO	TO	_	28	case	_	_
28	stress	stress	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	JNK	jnk	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	involved	involve	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	signal	signal	NN	NN	_	6	compound	_	_
6	integration	integration	NN	NN	_	3	nmod	_	_
7	during	during	IN	IN	_	8	case	_	_
8	costimulation	costimulation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	interleukin-2	interleukin-2	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-2	il-2	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	production	production	NN	NN	_	3	conj	_	_
10	require	require	VBP	VBP	_	0	root	_	_
11	at	at	IN	IN	_	12	case	_	_
12	least	least	JJS	JJS	_	13	nmod:npmod	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	signals	signal	NNS	NNS	_	10	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	generated	generate	VBN	VBN	_	14	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	ester	ester	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	TPA	tpa	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	Ca2+	ca2+	NN	NN	_	25	compound	_	_
25	ionophore	ionophore	NN	NN	_	19	conj	_	_
26	or	or	CC	CC	_	19	cc	_	_
27	costimulation	costimulation	NN	NN	_	19	conj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	receptor	receptor	NN	NN	_	27	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	TCR	tcr	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	the	the	DT	DT	_	40	det	_	_
38	CD28	cd28	NN	NN	_	40	compound	_	_
39	auxiliary	auxiliary	NN	NN	_	40	compound	_	_
40	receptor	receptor	NN	NN	_	32	conj	_	_
41	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	how	how	WRB	WRB	_	6	advmod	_	_
4	these	these	DT	DT	_	5	det	_	_
5	stimuli	stimulus	NNS	NNS	_	6	nsubj	_	_
6	affect	affect	VBP	VBP	_	2	ccomp	_	_
7	mitogen	mitogen	NN	NN	_	13	compound	_	_
8	activated	activated	JJ	JJ	_	13	amod	_	_
9	protein	protein	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	MAP	map	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	kinases	kinase	NNS	NNS	_	6	dobj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Full	full	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	MAP	map	NN	NN	_	6	compound	_	_
6	kinases	kinase	NNS	NNS	_	2	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	phosphorylate	phosphorylate	VBP	VBP	_	6	acl:relcl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	Jun	jun	NN	NN	_	12	compound	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	JNK1	jnk1	NN	NN	_	12	appos	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	JNK2	jnk2	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	2	punct	_	_
18	required	require	VBD	VBD	_	0	root	_	_
19	costimulation	costimulation	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	either	either	CC	CC	_	25	cc:preconj	_	_
25	TPA	tpa	NN	NN	_	19	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	Ca2+	ca2+	NN	NN	_	28	compound	_	_
28	ionophore	ionophore	NN	NN	_	25	conj	_	_
29	or	or	CC	CC	_	25	cc	_	_
30	antibodies	antibody	NNS	NNS	_	25	conj	_	_
31	to	to	TO	TO	_	32	case	_	_
32	TCR	tcr	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	CD28	cd28	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	18	punct	_	_

1	Alone	alone	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	each	each	DT	DT	_	4	det	_	_
4	stimulus	stimulus	NN	NN	_	5	nsubj	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	little	little	JJ	JJ	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	no	no	DT	DT	_	7	conj	_	_
10	activation	activation	NN	NN	_	7	dep	_	_
11	.	.	.	.	_	5	punct	_	_

1	Similar	similar	JJ	JJ	_	14	advmod	_	_
2	to	to	TO	TO	_	4	case	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	effect	effect	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	14	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CsA	csa	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	inhibited	inhibit	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	synergistic	synergistic	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	JNK	jnk	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	a	a	DT	DT	_	24	det	_	_
23	competitive	competitive	JJ	JJ	_	24	amod	_	_
24	inhibitor	inhibitor	NN	NN	_	30	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	Jun	jun	NN	NN	_	27	compound	_	_
27	phosphorylation	phosphorylation	NN	NN	_	24	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	JNK	jnk	NN	NN	_	24	nmod	_	_
30	inhibited	inhibit	VBD	VBD	_	14	conj	_	_
31	IL-2	il-2	NN	NN	_	33	compound	_	_
32	promoter	promoter	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	14	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	MAP	map	NN	NN	_	6	compound	_	_
6	kinases	kinase	NNS	NNS	_	12	nsubjpass	_	_
7	ERK1	erk1	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ERK2	erk2	NN	NN	_	7	conj	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	fully	fully	RB	RB	_	12	advmod	_	_
12	activated	activate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	TPA	tpa	NN	NN	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	TCR	tcr	NN	NN	_	14	conj	_	_
17	stimulation	stimulation	NN	NN	_	14	dep	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	were	be	VBD	VBD	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	affected	affect	VBN	VBN	_	12	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	Ca2+	ca2+	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	CD28	cd28	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	CsA	csa	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	12	punct	_	_

1	Hence	hence	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	integration	integration	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	signals	signal	NNS	NNS	_	3	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	lead	lead	VBP	VBP	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	occurs	occur	VBZ	VBZ	_	0	root	_	_
13	at	at	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	level	level	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	JNK	jnk	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	10	case	_	_
4	interleukin-2	interleukin-2	NN	NN	_	10	compound	_	_
5	receptor	receptor	NN	NN	_	10	compound	_	_
6	alpha	alpha	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	-beta	-beta	NN	NN	_	6	conj	_	_
9	subunit	subunit	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	2	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	36	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	10	nmod:npmod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	GC	gc	NN	NN	_	10	nmod:npmod	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	-mediated	-mediated	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	functions	function	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	36	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	36	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	dexamethasone	dexamethasone	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	DM	dm	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	on	on	IN	IN	_	27	case	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	proliferation	proliferation	NN	NN	_	18	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	interleukin-2	interleukin-2	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	IL-2R	il-2r	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	generation	generation	NN	NN	_	27	conj	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	studied	study	VBN	VBN	_	0	root	_	_
37	.	.	.	.	_	36	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	IL-2-induced	il-2-induced	JJ	JJ	_	6	amod	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	2	dobj	_	_
7	by	by	IN	IN	_	12	case	_	_
8	30	30	CD	CD	_	12	nummod	_	_
9	%	%	NN	NN	_	12	compound	_	_
10	-	-	TO	TO	_	12	dep	_	_
11	88	88	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	relative	relative	JJ	JJ	_	17	case	_	_
15	to	to	TO	TO	_	17	case	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	concentration	concentration	NN	NN	_	2	nmod	_	_
18	within	within	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cultures	culture	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	28	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	DM	dm	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	6	case	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	22	case	_	_
8	IL-2R	il-2r	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	22	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Tac	tac	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	p55	p55	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	CD25	cd25	NN	NN	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	11	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	beta	beta	NN	NN	_	9	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	p75	p75	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	genes	gene	NNS	NNS	_	6	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	activated	activate	VBN	VBN	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	6	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	examined	examine	VBN	VBN	_	0	root	_	_
29	next	next	RB	RB	_	28	advmod	_	_
30	.	.	.	.	_	28	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	25	nmod	_	_
4	stimulated	stimulate	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	purified	purify	VBN	VBN	_	7	amod	_	_
7	phytohemagglutinin	phytohemagglutinin	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PHA-p	pha-p	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	4	4	CD	CD	_	15	nummod	_	_
13	beta-phorbol	beta-phorbol	NN	NN	_	15	compound	_	_
14	12-myristate	12-myristate	NN	NN	_	15	compound	_	_
15	13-acetate	13-acetate	NN	NN	_	7	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	addition	addition	NN	NN	_	25	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	DM	dm	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cultures	culture	NNS	NNS	_	19	nmod	_	_
25	resulted	result	VBD	VBD	_	0	root	_	_
26	in	in	IN	IN	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	60	60	CD	CD	_	30	nummod	_	_
29	%	%	NN	NN	_	30	compound	_	_
30	reduction	reduction	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	IL-2R	il-2r	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	a	a	DT	DT	_	38	det	_	_
36	30	30	CD	CD	_	38	nummod	_	_
37	%	%	NN	NN	_	38	compound	_	_
38	reduction	reduction	NN	NN	_	30	conj	_	_
39	in	in	IN	IN	_	43	case	_	_
40	IL-2R	il-2r	NN	NN	_	43	compound	_	_
41	beta	beta	NN	NN	_	43	compound	_	_
42	membrane	membrane	NN	NN	_	43	compound	_	_
43	expression	expression	NN	NN	_	38	nmod	_	_
44	compared	compare	VBN	VBN	_	25	dep	_	_
45	to	to	TO	TO	_	47	case	_	_
46	T	t	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	44	nmod	_	_
48	cultured	culture	VBN	VBN	_	47	acl	_	_
49	in	in	IN	IN	_	53	case	_	_
50	the	the	DT	DT	_	53	dep	_	_
51	absence	absence	NN	NN	_	53	dep	_	_
52	of	of	IN	IN	_	53	case	_	_
53	DM	dm	NN	NN	_	48	nmod	_	_
54	(	(	-LRB-	-LRB-	_	57	punct	_	_
55	p	p	NN	NN	_	57	dep	_	_
56	&lt;	&lt;	JJR	JJR	_	57	advmod	_	_
57	0.01	0.01	CD	CD	_	48	parataxis	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	25	punct	_	_

1	Inhibition	inhibition	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	membrane	membrane	NN	NN	_	9	compound	_	_
4	IL-2R	il-2r	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-2R	il-2r	NN	NN	_	8	compound	_	_
8	beta	beta	NN	NN	_	5	conj	_	_
9	expression	expression	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	10(-6)	10(-6)	CD	CD	_	12	compound	_	_
12	M	m	NN	NN	_	13	amod	_	_
13	DM	dm	NN	NN	_	1	nmod	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	partially	partially	RB	RB	_	16	advmod	_	_
16	reversible	reversible	JJ	JJ	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	recombinant	recombinant	JJ	JJ	_	20	amod	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	IL-2	il-2	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	rhIL-2	rhil-2	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	16	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	Northern	northern	JJ	JJ	_	4	amod	_	_
3	blot	blot	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	DM	dm	NN	NN	_	7	nsubj	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	comparable	comparable	JJ	JJ	_	10	amod	_	_
10	decrease	decrease	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	IL-2R	il-2r	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	19	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	in	in	IN	IN	_	17	case	_	_
16	IL-2R	il-2r	NN	NN	_	17	compound	_	_
17	beta	beta	NN	NN	_	13	conj	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	10	nmod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	membrane	membrane	NN	NN	_	23	compound	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	7	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	mitogen-stimulated	mitogen-stimulated	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	By	by	IN	IN	_	5	case	_	_
2	in	in	FW	FW	_	5	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	DM	dm	NN	NN	_	8	nsubj	_	_
8	regulated	regulate	VBD	VBD	_	0	root	_	_
9	IL-2R	il-2r	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	dobj	_	_
13	at	at	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	level	level	NN	NN	_	12	nmod	_	_
17	while	while	IN	IN	_	24	mark	_	_
18	transcription	transcription	NN	NN	_	24	nsubjpass	_	_
19	of	of	IN	IN	_	22	case	_	_
20	IL-2R	il-2r	NN	NN	_	22	compound	_	_
21	beta	beta	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	unaffected	unaffect	VBN	VBN	_	8	advcl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	DM	dm	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	action	action	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	DM	dm	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	IL-2R	il-2r	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	4	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	examined	examine	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	determining	determine	VBG	VBG	_	12	advcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p50	p50	NN	NN	_	21	compound	_	_
21	subunit	subunit	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
24	factor	factor	NN	NN	_	26	compound	_	_
25	kappa	kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	21	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	26	punct	_	_
32	a	a	DT	DT	_	34	det	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	26	appos	_	_
35	that	that	WDT	WDT	_	36	nsubj	_	_
36	stimulates	stimulate	VBZ	VBZ	_	34	acl:relcl	_	_
37	IL-2R	il-2r	NN	NN	_	40	compound	_	_
38	alpha	alpha	NN	NN	_	40	compound	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	36	dobj	_	_
41	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	10(-6)	10(-6)	CD	CD	_	6	compound	_	_
6	M	m	NN	NN	_	7	amod	_	_
7	DM	dm	NN	NN	_	8	nsubj	_	_
8	increased	increase	VBD	VBD	_	3	ccomp	_	_
9	T	t	NN	NN	_	15	compound	_	_
10	cell	cell	NN	NN	_	15	compound	_	_
11	p50	p50	NN	NN	_	15	compound	_	_
12	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	8	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	four-fold	four-fold	JJ	JJ	_	8	nmod	_	_
18	compared	compare	VBN	VBN	_	8	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	levels	level	NNS	NNS	_	18	nmod	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	dep	_	_
25	absence	absence	NN	NN	_	27	dep	_	_
26	of	of	IN	IN	_	27	case	_	_
27	DM	dm	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Further	further	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	level	level	NN	NN	_	20	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	4	nmod	_	_
8	capable	capable	JJ	JJ	_	7	amod	_	_
9	of	of	IN	IN	_	10	mark	_	_
10	binding	bind	VBG	VBG	_	8	advcl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	activated	activate	VBN	VBN	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	increased	increase	VBD	VBD	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	response	response	NN	NN	_	24	dep	_	_
23	to	to	TO	TO	_	24	case	_	_
24	DM	dm	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	sum	sum	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	DM	dm	NN	NN	_	5	nsubj	_	_
5	regulates	regulate	VBZ	VBZ	_	0	root	_	_
6	T	t	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	IL-2R	il-2r	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	more	more	JJR	JJR	_	15	advmod	_	_
14	than	than	IN	IN	_	13	mwe	_	_
15	one	one	CD	CD	_	17	nummod	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	mechanism	mechanism	NN	NN	_	5	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HIV	hiv	NN	NN	_	4	compound	_	_
4	replication	replication	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	phagocytes	phagocyte	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	leukemia	leukemia	NN	NN	_	11	compound	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	leukemia	leukemia	NN	NN	_	9	compound	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LIF	lif	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	on	on	IN	IN	_	20	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	16	compound	_	_
16	virus	virus	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HIV	hiv	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	replication	replication	NN	NN	_	5	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	phagocytes	phagocyte	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	MNP	mnp	NNS	NNS	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	3	punct	_	_

1	LIF	lif	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	dose-dependent	dose-dependent	JJ	JJ	_	5	amod	_	_
5	increase	increase	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	p24	p24	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	chronically	chronically	RB	RB	_	17	advmod	_	_
13	infected	infected	JJ	JJ	_	17	amod	_	_
14	promonocytic	promonocytic	JJ	JJ	_	17	amod	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	line	line	NN	NN	_	17	compound	_	_
17	U1	u1	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	11	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	time	time	NN	NN	_	5	compound	_	_
5	kinetics	kinetics	NNS	NNS	_	2	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	LIF	lif	NN	NN	_	9	compound	_	_
9	effects	effect	NNS	NNS	_	2	nmod	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	similar	similar	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	interleukin	interleukin	NN	NN	_	11	nmod	_	_
14	1	1	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-1	il-1	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	13	punct	_	_
19	IL-6	il-6	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	tumor	tumor	NN	NN	_	24	compound	_	_
23	necrosis	necrosis	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	13	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TNF	tnf	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	13	punct	_	_
29	other	other	JJ	JJ	_	30	amod	_	_
30	cytokines	cytokine	NNS	NNS	_	13	conj	_	_
31	known	know	VBN	VBN	_	30	acl	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	induce	induce	VB	VB	_	31	xcomp	_	_
34	HIV	hiv	NN	NN	_	35	compound	_	_
35	replication	replication	NN	NN	_	33	dobj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	this	this	DT	DT	_	39	det	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
4	responsible	responsible	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	LIF	lif	NN	NN	_	8	compound	_	_
8	effects	effect	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	levels	level	NNS	NNS	_	39	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	activation	activation	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	DNA	dna	NN	NN	_	22	compound	_	_
19	binding	binding	NN	NN	_	22	compound	_	_
20	protein	protein	NN	NN	_	22	compound	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	15	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	NF	nf	NN	NN	_	22	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	-kB	-kb	NN	NN	_	24	dep	_	_
27	,	,	,	,	_	10	punct	_	_
28	signal	signal	NN	NN	_	30	compound	_	_
29	transduction	transduction	NN	NN	_	30	compound	_	_
30	pathways	pathway	NNS	NNS	_	10	conj	_	_
31	,	,	,	,	_	10	punct	_	_
32	and	and	CC	CC	_	10	cc	_	_
33	potential	potential	JJ	JJ	_	34	amod	_	_
34	interactions	interaction	NNS	NNS	_	10	conj	_	_
35	with	with	IN	IN	_	37	case	_	_
36	other	other	JJ	JJ	_	37	amod	_	_
37	cytokines	cytokine	NNS	NNS	_	34	nmod	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	analyzed	analyze	VBN	VBN	_	2	parataxis	_	_
40	.	.	.	.	_	2	punct	_	_

1	LIF	lif	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	steady-state	steady-state	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	at	at	IN	IN	_	9	case	_	_
9	2.0	2.0	CD	CD	_	2	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	4.3	4.3	CD	CD	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	9.2	9.2	CD	CD	_	9	conj	_	_
15	kB	kb	NN	NN	_	9	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	detectable	detectable	JJ	JJ	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	24	24	CD	CD	_	6	nummod	_	_
6	h	h	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	persisted	persist	VBD	VBD	_	3	conj	_	_
9	until	until	IN	IN	_	11	case	_	_
10	72	72	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	DNA	dna	NN	NN	_	5	compound	_	_
3	binding	binding	NN	NN	_	5	compound	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	NF-kB	nf-kb	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	central	central	JJ	JJ	_	9	amod	_	_
9	mediator	mediator	NN	NN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	NF-kB	nf-kb	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	higher	higher	JJR	JJR	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	unstimulated	unstimulated	JJ	JJ	_	8	amod	_	_
7	U1	u1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	as	as	IN	IN	_	10	mark	_	_
10	compared	compare	VBN	VBN	_	4	advcl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	parent	parent	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	10	nmod	_	_
16	U937	u937	NN	NN	_	15	dep	_	_
17	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	both	both	DT	DT	_	4	det	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	6	nmod	_	_
5	LIF	lif	NN	NN	_	6	nsubj	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	NF-kB	nf-kb	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	.	.	.	.	_	6	punct	_	_

1	Induction	induction	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-kB	nf-kb	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	1	conj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
9	are	be	VBP	VBP	_	14	cop	_	_
10	at	at	IN	IN	_	13	advmod	_	_
11	least	least	JJS	JJS	_	10	mwe	_	_
12	in	in	IN	IN	_	13	case	_	_
13	part	part	NN	NN	_	14	nmod	_	_
14	dependent	dependent	JJ	JJ	_	0	root	_	_
15	on	on	IN	IN	_	18	case	_	_
16	reactive	reactive	JJ	JJ	_	18	amod	_	_
17	oxygen	oxygen	NN	NN	_	18	compound	_	_
18	intermediates	intermediate	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	oxygen	oxygen	NN	NN	_	5	compound	_	_
3	radical	radical	JJ	JJ	_	5	amod	_	_
4	scavenger	scavenger	NN	NN	_	5	compound	_	_
5	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	16	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	an	a	DT	DT	_	10	det	_	_
10	inhibitor	inhibitor	NN	NN	_	5	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	nitric	nitric	JJ	JJ	_	14	amod	_	_
13	oxide	oxide	NN	NN	_	14	compound	_	_
14	synthase	synthase	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	inhibited	inhibit	VBD	VBD	_	0	root	_	_
17	LIF-induced	lif-induced	JJ	JJ	_	19	amod	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	LIF	lif	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	production	production	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
10	but	but	CC	CC	_	2	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	effects	effect	NNS	NNS	_	18	nsubjpass	_	_
13	on	on	IN	IN	_	15	case	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	12	nmod	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	inhibited	inhibit	VBN	VBN	_	2	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	antibodies	antibody	NNS	NNS	_	18	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	IL-1	il-1	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	TNF	tnf	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	or	or	CC	CC	_	22	cc	_	_
27	IL-6	il-6	NN	NN	_	22	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	LIF	lif	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	stimulus	stimulus	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
3	virus	virus	NN	NN	_	6	compound	_	_
4	type	type	NN	NN	_	6	compound	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	Tat	tat	NN	NN	_	7	nsubj	_	_
7	upregulates	upregulate	VBZ	VBZ	_	0	root	_	_
8	interleukin-2	interleukin-2	NN	NN	_	9	compound	_	_
9	secretion	secretion	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Dysregulation	dysregulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
4	secreted	secrete	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	play	play	VB	VB	_	0	root	_	_
10	an	a	DT	DT	_	12	det	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	pathogenesis	pathogenesis	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	AIDS	aids	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	14	case	_	_
6	human	human	JJ	JJ	_	14	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	14	compound	_	_
8	virus	virus	NN	NN	_	14	compound	_	_
9	type	type	NN	NN	_	14	compound	_	_
10	1	1	CD	CD	_	14	nummod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	Tat	tat	NN	NN	_	4	nmod	_	_
15	on	on	IN	IN	_	20	case	_	_
16	interleukin-2	interleukin-2	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL-2	il-2	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	expression	expression	NN	NN	_	4	nmod	_	_
21	,	,	,	,	_	2	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	used	use	VBD	VBD	_	2	parataxis	_	_
24	IL-2	il-2	NN	NN	_	27	compound	_	_
25	promoter-chloramphenicol	promoter-chloramphenicol	JJ	JJ	_	27	amod	_	_
26	acetyltransferase	acetyltransferase	NN	NN	_	27	compound	_	_
27	constructs	construct	NNS	NNS	_	23	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	IL-2-secreting	il-2-secreting	JJ	JJ	_	32	amod	_	_
30	Jurkat	jurkat	NN	NN	_	32	compound	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	conj	_	_
33	as	as	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	model	model	NN	NN	_	36	compound	_	_
36	system	system	NN	NN	_	23	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	Tat	tat	NN	NN	_	2	nmod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	11	det	_	_
8	five-	five-	CD	CD	_	10	compound	_	_
9	to	to	TO	TO	_	10	dep	_	_
10	eightfold	eightfold	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	6	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	IL-2	il-2	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	Jurkat	jurkat	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	stimulated	stimulate	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	phytohemagglutinin	phytohemagglutinin	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	phorbol	phorbol	NN	NN	_	26	compound	_	_
25	myristate	myristate	NN	NN	_	26	compound	_	_
26	acetate	acetate	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	secretion	secretion	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	increased	increase	VBN	VBN	_	0	root	_	_
5	more	more	JJR	JJR	_	4	dobj	_	_
6	than	than	IN	IN	_	5	amod	_	_
7	twofold	twofold	RB	RB	_	5	advmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	both	both	CC	CC	_	12	cc:preconj	_	_
10	Jurkat	jurkat	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	primary	primary	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	conj	_	_
17	stimulated	stimulate	VBN	VBN	_	12	acl	_	_
18	by	by	IN	IN	_	22	case	_	_
19	extracellular	extracellular	JJ	JJ	_	22	amod	_	_
20	HIV-1	hiv-1	NN	NN	_	22	compound	_	_
21	Tat	tat	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Analysis	analysis	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	mRNA	mrna	NN	NN	_	1	nmod	_	_
4	suggested	suggest	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	Tat	tat	NN	NN	_	7	nsubj	_	_
7	exerts	exert	VBZ	VBZ	_	4	ccomp	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	11	case	_	_
11	IL-2	il-2	NN	NN	_	9	nmod	_	_
12	primarily	primarily	RB	RB	_	7	advmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	level	level	NN	NN	_	7	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	15	nsubj	_	_
5	at	at	IN	IN	_	6	case	_	_
6	positions	position	NNS	NNS	_	4	nmod	_	_
7	-206	-206	CD	CD	_	9	nummod	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	-195	-195	CD	CD	_	6	dep	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	6	nmod	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	required	require	VBN	VBN	_	0	root	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	15	cc	_	_
18	sufficient	sufficient	JJ	JJ	_	15	conj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	Tat	tat	NN	NN	_	22	compound	_	_
22	effect	effect	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tat-mediated	tat-mediated	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	11	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	IL-2	il-2	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	nmod	_	_
8	could	could	MD	MD	_	11	aux	_	_
9	selectively	selectively	RB	RB	_	11	advmod	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	blocked	block	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	antisense	antisense	JJ	JJ	_	14	amod	_	_
14	tat	tat	NN	NN	_	11	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	-	-	:	:	_	14	punct	_	_
17	unlike	unlike	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	analogous	analogous	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	14	conj	_	_
21	of	of	IN	IN	_	28	case	_	_
22	human	human	JJ	JJ	_	28	amod	_	_
23	T-cell	t-cell	NN	NN	_	28	compound	_	_
24	lymphotropic	lymphotropic	JJ	JJ	_	28	amod	_	_
25	virus	virus	NN	NN	_	28	compound	_	_
26	type	type	NN	NN	_	28	compound	_	_
27	1	1	CD	CD	_	28	nummod	_	_
28	Tax	tax	NN	NN	_	20	nmod	_	_
29	-	-	:	:	_	14	punct	_	_
30	by	by	IN	IN	_	32	case	_	_
31	cyclosporin	cyclosporin	NN	NN	_	32	compound	_	_
32	A	a	NN	NN	_	14	conj	_	_
33	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	observed	observe	VBN	VBN	_	3	amod	_	_
3	increase	increase	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	might	might	MD	MD	_	8	aux	_	_
8	facilitate	facilitate	VB	VB	_	0	root	_	_
9	virus	virus	NN	NN	_	8	dobj	_	_
10	spread	spread	VBN	VBN	_	9	amod	_	_
11	from	from	IN	IN	_	15	nmod	_	_
12	or	or	CC	CC	_	15	cc	_	_
13	to	to	TO	TO	_	15	conj	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubj	_	_
4	might	might	MD	MD	_	5	aux	_	_
5	contribute	contribute	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	hypergammaglobulinemia	hypergammaglobulinemia	NN	NN	_	5	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	,	,	,	,	_	8	punct	_	_
11	together	together	RB	RB	_	14	advmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	other	other	JJ	JJ	_	14	amod	_	_
14	cytokines	cytokine	NNS	NNS	_	8	conj	_	_
15	found	find	VBN	VBN	_	14	acl	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	dysregulated	dysregulate	VBN	VBN	_	15	xcomp	_	_
19	,	,	,	,	_	8	punct	_	_
20	the	the	DT	DT	_	23	det	_	_
21	T-helper	t-helper	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	dysfunctions	dysfunction	NNS	NNS	_	8	conj	_	_
24	observed	observe	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	AIDS	aids	NN	NN	_	27	compound	_	_
27	patients	patient	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Tolerance	tolerance	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	nmod	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	mobilization	mobilization	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	5	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	predominance	predominance	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	p50	p50	NN	NN	_	15	compound	_	_
15	homodimers	homodimer	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	1	nmod	_	_
8	Mono	mono	NN	NN	_	9	compound	_	_
9	Mac	mac	NN	NN	_	7	dep	_	_
10	6	6	CD	CD	_	9	nummod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LPS	lps	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	leads	lead	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	21	case	_	_
18	rapid	rapid	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	transient	transient	JJ	JJ	_	18	conj	_	_
21	expression	expression	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
24	like	like	IN	IN	_	27	case	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TNF	tnf	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	such	such	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	precultured	preculture	VBN	VBN	_	39	advcl	_	_
6	for	for	IN	IN	_	8	case	_	_
7	2	2	CD	CD	_	8	nummod	_	_
8	days	day	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	dose	dose	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	LPS	lps	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	20	20	CD	CD	_	17	nummod	_	_
17	ng/ml	ng/ml	NN	NN	_	12	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	followed	follow	VBN	VBN	_	5	dep	_	_
20	by	by	IN	IN	_	21	case	_	_
21	stimulation	stimulation	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	high	high	JJ	JJ	_	25	amod	_	_
25	dose	dose	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	LPS	lps	NN	NN	_	25	nmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	1	1	CD	CD	_	30	nummod	_	_
30	microgram/ml	microgram/ml	NN	NN	_	25	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	39	punct	_	_
33	expression	expression	NN	NN	_	39	nsubj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	TNF	tnf	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	33	nmod	_	_
38	is	be	VBZ	VBZ	_	39	cop	_	_
39	minimal	minimal	JJ	JJ	_	0	root	_	_
40	,	,	,	,	_	39	punct	_	_
41	i.e.	i.e.	FW	FW	_	39	advcl	_	_
42	the	the	DT	DT	_	43	det	_	_
43	cells	cell	NNS	NNS	_	45	nsubj	_	_
44	are	be	VBP	VBP	_	45	cop	_	_
45	tolerant	tolerant	JJ	JJ	_	39	parataxis	_	_
46	.	.	.	.	_	39	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	run-on	run-on	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	such	such	JJ	JJ	_	8	amod	_	_
7	tolerant	tolerant	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	show	show	VBP	VBP	_	0	root	_	_
10	only	only	RB	RB	_	13	advmod	_	_
11	a	a	DT	DT	_	13	det	_	_
12	low	low	JJ	JJ	_	13	amod	_	_
13	degree	degree	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	indicating	indicate	VBG	VBG	_	9	advcl	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	tolerance	tolerance	NN	NN	_	20	nsubj	_	_
20	operates	operate	VBZ	VBZ	_	17	ccomp	_	_
21	at	at	IN	IN	_	20	dep	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	upstream	upstream	RB	RB	_	21	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	level	level	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	CD14	cd14	NN	NN	_	4	compound	_	_
3	LPS	lps	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	aux	_	_
6	,	,	,	,	_	9	punct	_	_
7	however	however	RB	RB	_	9	advmod	_	_
8	,	,	,	,	_	9	punct	_	_
9	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	not	not	RB	RB	_	12	dep	_	_
12	down-regulated	down-regulate	VBN	VBN	_	9	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	tolerant	tolerant	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	LPS	lps	NN	NN	_	26	nsubj	_	_
20	can	can	MD	MD	_	26	aux	_	_
21	,	,	,	,	_	26	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	fact	fact	NN	NN	_	26	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	still	still	RB	RB	_	26	advmod	_	_
26	lead	lead	VB	VB	_	9	conj	_	_
27	to	to	TO	TO	_	28	case	_	_
28	activation	activation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	tolerant	tolerant	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	as	as	IN	IN	_	33	mark	_	_
33	evidenced	evidence	VBN	VBN	_	26	advcl	_	_
34	by	by	IN	IN	_	35	case	_	_
35	mobilization	mobilization	NN	NN	_	33	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factor	factor	NN	NN	_	35	nmod	_	_
40	nuclear	nuclear	JJ	JJ	_	43	amod	_	_
41	factor	factor	NN	NN	_	43	compound	_	_
42	kappa	kappa	NN	NN	_	43	compound	_	_
43	B	b	NN	NN	_	39	dep	_	_
44	(	(	-LRB-	-LRB-	_	46	punct	_	_
45	NF-kappa	nf-kappa	NN	NN	_	46	compound	_	_
46	B	b	NN	NN	_	43	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	.	.	.	.	_	9	punct	_	_

1	Resolution	resolution	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	gel	gel	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	analysis	analysis	NN	NN	_	1	nmod	_	_
11	shows	show	VBZ	VBZ	_	0	root	_	_
12	that	that	IN	IN	_	25	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	protein	protein	NN	NN	_	25	nsubj	_	_
16	,	,	,	,	_	15	punct	_	_
17	mobilized	mobilize	VBN	VBN	_	15	acl	_	_
18	in	in	IN	IN	_	23	case	_	_
19	naive	naive	JJ	JJ	_	23	amod	_	_
20	Mono	mono	NN	NN	_	23	compound	_	_
21	Mac	mac	NN	NN	_	23	compound	_	_
22	6	6	CD	CD	_	23	nummod	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	consists	consist	VBZ	VBZ	_	11	ccomp	_	_
26	mainly	mainly	RB	RB	_	25	advmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	p50-p65	p50-p65	NN	NN	_	29	compound	_	_
29	heterodimers	heterodimer	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	25	punct	_	_
31	while	while	IN	IN	_	40	mark	_	_
32	in	in	IN	IN	_	34	case	_	_
33	tolerant	tolerant	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	40	nmod	_	_
35	,	,	,	,	_	40	punct	_	_
36	the	the	DT	DT	_	38	det	_	_
37	p50	p50	NN	NN	_	38	compound	_	_
38	homodimer	homodimer	NN	NN	_	40	nsubj	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	predominant	predominant	JJ	JJ	_	25	advcl	_	_
41	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	p50	p50	NN	NN	_	5	compound	_	_
5	homodimers	homodimer	NNS	NNS	_	2	nmod	_	_
6	coincides	coincide	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	increase	increase	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	p105	p105	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	suggestive	suggestive	JJ	JJ	_	6	advmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	up-regulation	up-regulation	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	p50	p50	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Reporter	reporter	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	reveals	reveal	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	16	nsubj	_	_
10	mobilized	mobilize	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	tolerant	tolerant	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	functionally	functionally	RB	RB	_	16	advmod	_	_
16	inactive	inactive	JJ	JJ	_	4	ccomp	_	_
17	in	in	IN	IN	_	35	mark	_	_
18	that	that	IN	IN	_	35	mark	_	_
19	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
20	B-dependent	b-dependent	JJ	JJ	_	22	amod	_	_
21	luciferase	luciferase	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	35	nsubj	_	_
23	containing	contain	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	30	det	_	_
25	human	human	JJ	JJ	_	30	amod	_	_
26	immunodeficiency	immunodeficiency	NN	NN	_	30	compound	_	_
27	virus	virus	NN	NN	_	30	compound	_	_
28	long	long	JJ	JJ	_	30	amod	_	_
29	terminal	terminal	JJ	JJ	_	30	amod	_	_
30	repeat	repeat	NN	NN	_	23	dobj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	34	det	_	_
33	TNF	tnf	NN	NN	_	34	compound	_	_
34	5'-region	5'-region	NN	NN	_	30	conj	_	_
35	show	show	VBP	VBP	_	16	advcl	_	_
36	only	only	RB	RB	_	38	advmod	_	_
37	minimal	minimal	JJ	JJ	_	38	amod	_	_
38	transactivation	transactivation	NN	NN	_	35	dobj	_	_
39	after	after	IN	IN	_	41	case	_	_
40	LPS	lps	NN	NN	_	41	compound	_	_
41	stimulation	stimulation	NN	NN	_	35	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	22	advmod	_	_
2	to	to	TO	TO	_	6	case	_	_
3	Mono	mono	NN	NN	_	6	compound	_	_
4	Mac	mac	NN	NN	_	6	compound	_	_
5	6	6	CD	CD	_	6	nummod	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	22	punct	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	monocytes	monocyte	NNS	NNS	_	22	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	precultured	preculture	VBN	VBN	_	22	advcl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	low	low	JJ	JJ	_	17	amod	_	_
17	dose	dose	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	LPS	lps	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	become	become	VBP	VBP	_	0	root	_	_
23	tolerant	tolerant	JJ	JJ	_	22	xcomp	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	produce	produce	VBP	VBP	_	22	conj	_	_
26	little	little	JJ	JJ	_	27	amod	_	_
27	TNF	tnf	NN	NN	_	25	dobj	_	_
28	after	after	IN	IN	_	30	case	_	_
29	LPS	lps	NN	NN	_	30	compound	_	_
30	stimulation	stimulation	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	tolerant	tolerant	JJ	JJ	_	4	amod	_	_
3	blood	blood	NN	NN	_	4	compound	_	_
4	monocytes	monocyte	NNS	NNS	_	6	nsubj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	up-regulate	up-regulate	VBP	VBP	_	0	root	_	_
7	CD14	cd14	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	6	punct	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	they	they	PRP	PRP	_	11	nsubj	_	_
11	mobilize	mobilize	VBP	VBP	_	6	conj	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	11	dobj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	predominance	predominance	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	p50	p50	NN	NN	_	19	compound	_	_
19	homodimers	homodimer	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	tolerance	tolerance	NN	NN	_	12	nsubjpass	_	_
9	to	to	TO	TO	_	10	case	_	_
10	LPS	lps	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	determined	determine	VBN	VBN	_	6	ccomp	_	_
13	by	by	IN	IN	_	15	case	_	_
14	post-receptor	post-receptor	JJ	JJ	_	15	amod	_	_
15	mechanisms	mechanism	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	involve	involve	VBP	VBP	_	15	acl:relcl	_	_
18	an	a	DT	DT	_	20	det	_	_
19	altered	altered	JJ	JJ	_	20	amod	_	_
20	composition	composition	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Oct2-isoform	oct2-isoform	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Oct2-isoform	oct2-isoform	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	splenic	splenic	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	stimulated	stimulate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	lipopolysaccharide	lipopolysaccharide	NN	NN	_	9	conj	_	_
12	plus	plus	CC	CC	_	11	cc	_	_
13	phorbol-di-butyrate	phorbol-di-butyrate	NN	NN	_	11	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	analysed	analyse	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	cDNA	cdna	NN	NN	_	18	compound	_	_
18	cloning	cloning	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	frequency	frequency	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Oct2-positive	oct2-positive	JJ	JJ	_	5	amod	_	_
5	clones	clone	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	1/15,000	1/15,000	CD	CD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	both	both	DT	DT	_	10	det	_	_
10	libraries	library	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	isoforms	isoform	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	generate	generate	VBP	VBP	_	5	dep	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	amino-	amino-	NN	NN	_	7	dobj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	carboxy-terminal	carboxy-terminal	JJ	JJ	_	9	conj	_	_
12	sequences	sequence	NNS	NNS	_	9	dep	_	_
13	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	isoform	isoform	NN	NN	_	6	nsubj	_	_
3	lacking	lack	VBG	VBG	_	2	acl	_	_
4	exon	exon	NN	NN	_	3	dobj	_	_
5	11	11	CD	CD	_	4	nummod	_	_
6	destroyed	destroy	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	carboxy-terminal	carboxy-terminal	JJ	JJ	_	10	amod	_	_
9	leucin-zipper	leucin-zipper	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	6	dobj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	introduced	introduce	VBD	VBD	_	6	conj	_	_
13	a	a	DT	DT	_	15	det	_	_
14	frame	frame	NN	NN	_	15	compound	_	_
15	shift	shift	NN	NN	_	12	dobj	_	_
16	creating	create	VBG	VBG	_	15	acl	_	_
17	a	a	DT	DT	_	22	det	_	_
18	novel	novel	JJ	JJ	_	22	amod	_	_
19	,	,	,	,	_	22	punct	_	_
20	proline-rich	proline-rich	JJ	JJ	_	22	amod	_	_
21	carboxy	carboxy	NN	NN	_	22	compound	_	_
22	terminus	terminus	NN	NN	_	16	dobj	_	_
23	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	exon	exon	NN	NN	_	13	nsubjpass	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	a	a	DT	DT	_	8	det	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	basic	basic	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	4	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	4c	4c	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	characterized	characterize	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	between	between	IN	IN	_	16	amod	_	_
16	exons	exon	NNS	NNS	_	13	dobj	_	_
17	4	4	CD	CD	_	16	nummod	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	5	5	CD	CD	_	16	conj	_	_
20	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	exon	exon	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	inserted	insert	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	7	amod	_	_
6	glutamine-rich	glutamine-rich	JJ	JJ	_	7	amod	_	_
7	regions	region	NNS	NNS	_	4	dobj	_	_
8	2	2	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	3	3	CD	CD	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	carboxy	carboxy	JJ	JJ	_	13	amod	_	_
13	terminal	terminal	NN	NN	_	7	appos	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	tentative	tentative	JJ	JJ	_	18	amod	_	_
17	leucine-zipper	leucine-zipper	NN	NN	_	18	compound	_	_
18	structure	structure	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	29	nmod	_	_
3	,	,	,	,	_	29	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	new	new	JJ	JJ	_	7	amod	_	_
6	combination	combination	NN	NN	_	7	compound	_	_
7	isoform	isoform	NN	NN	_	29	nsubjpass	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	Oct2a	oct2a	NN	NN	_	13	nmod:poss	_	_
10	's	's	POS	POS	_	13	case	_	_
11	amino	amino	NN	NN	_	13	compound	_	_
12	terminal	terminal	JJ	JJ	_	13	amod	_	_
13	insert	insert	NN	NN	_	8	dobj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	exon	exon	NN	NN	_	16	compound	_	_
16	7a	7a	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	Oct2b	oct2b	NN	NN	_	23	nmod:poss	_	_
20	's	's	POS	POS	_	23	case	_	_
21	carboxy	carboxy	NN	NN	_	23	compound	_	_
22	terminal	terminal	JJ	JJ	_	23	amod	_	_
23	insert	insert	NN	NN	_	13	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	exon	exon	NN	NN	_	23	appos	_	_
26	13	13	CD	CD	_	25	nummod	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	found	find	VBN	VBN	_	0	root	_	_
30	that	that	WDT	WDT	_	31	nsubj	_	_
31	created	create	VBD	VBD	_	29	dep	_	_
32	a	a	DT	DT	_	35	det	_	_
33	novel	novel	JJ	JJ	_	35	amod	_	_
34	large	large	JJ	JJ	_	33	dep	_	_
35	isoform	isoform	NN	NN	_	31	dobj	_	_
36	,	,	,	,	_	35	punct	_	_
37	Oct2ab	oct2ab	NN	NN	_	35	appos	_	_
38	.	.	.	.	_	29	punct	_	_

1	More	more	RBR	RBR	_	2	advmod	_	_
2	frequent	frequent	JJ	JJ	_	3	amod	_	_
3	use	use	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	dep	_	_
6	classical	classical	JJ	JJ	_	7	amod	_	_
7	Oct2a	oct2a	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Oct2b	oct2b	NN	NN	_	7	conj	_	_
10	isoforms	isoform	NNS	NNS	_	7	dep	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	while	while	IN	IN	_	29	mark	_	_
20	a	a	DT	DT	_	21	det	_	_
21	preference	preference	NN	NN	_	29	nsubjpass	_	_
22	for	for	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	Oct2ab	oct2ab	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Oct2ba	oct2ba	NN	NN	_	24	conj	_	_
27	isoforms	isoform	NNS	NNS	_	24	dep	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	observed	observe	VBN	VBN	_	12	advcl	_	_
30	in	in	IN	IN	_	34	case	_	_
31	lipopolysaccharide	lipopolysaccharide	NN	NN	_	34	compound	_	_
32	plus	plus	CC	CC	_	31	cc	_	_
33	phorbol-di-butyrate-treated	phorbol-di-butyrate-treated	JJ	JJ	_	31	conj	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	Function	function	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	activation	activation	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	system	system	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	ubiquitous	ubiquitous	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	properties	property	NNS	NNS	_	5	nsubj	_	_
5	seem	seem	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	auxpass	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	extensively	extensively	RB	RB	_	10	advmod	_	_
10	exploited	exploit	VBN	VBN	_	5	xcomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	system	system	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	properties	property	NNS	NNS	_	4	nmod	_	_
4	are	be	VBP	VBP	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	10	nmod:poss	_	_
7	's	's	POS	POS	_	6	case	_	_
8	rapid	rapid	JJ	JJ	_	10	amod	_	_
9	posttranslational	posttranslational	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	4	nsubj	_	_
11	in	in	IN	IN	_	16	case	_	_
12	response	response	NN	NN	_	16	dep	_	_
13	to	to	TO	TO	_	16	case	_	_
14	many	many	JJ	JJ	_	16	amod	_	_
15	pathogenic	pathogenic	JJ	JJ	_	16	amod	_	_
16	signals	signal	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	direct	direct	JJ	JJ	_	20	amod	_	_
20	participation	participation	NN	NN	_	10	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	cytoplasmic/nuclear	cytoplasmic/nuclear	JJ	JJ	_	23	amod	_	_
23	signaling	signaling	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	10	punct	_	_
25	and	and	CC	CC	_	10	cc	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	potency	potency	NN	NN	_	10	conj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	activate	activate	VB	VB	_	27	acl	_	_
30	transcription	transcription	NN	NN	_	29	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	great	great	JJ	JJ	_	34	amod	_	_
34	variety	variety	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	genes	gene	NNS	NNS	_	34	nmod	_	_
37	encoding	encode	VBG	VBG	_	36	acl	_	_
38	immunologically	immunologically	RB	RB	_	39	advmod	_	_
39	relevant	relevant	JJ	JJ	_	40	amod	_	_
40	proteins	protein	NNS	NNS	_	37	dobj	_	_
41	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	vertebrates	vertebrate	NNS	NNS	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	five	five	CD	CD	_	8	nummod	_	_
5	distinct	distinct	JJ	JJ	_	8	amod	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	subunits	subunit	NNS	NNS	_	11	nsubjpass	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	currently	currently	RB	RB	_	11	advmod	_	_
11	known	know	VBN	VBN	_	0	root	_	_
12	which	which	WDT	WDT	_	15	nsubj	_	_
13	might	might	MD	MD	_	15	aux	_	_
14	extensively	extensively	RB	RB	_	15	advmod	_	_
15	heterodimerize	heterodimerize	VB	VB	_	11	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	thereby	thereby	RB	RB	_	18	advmod	_	_
18	forming	form	VBG	VBG	_	15	xcomp	_	_
19	complexes	complex	NNS	NNS	_	18	dobj	_	_
20	with	with	IN	IN	_	23	case	_	_
21	distinct	distinct	JJ	JJ	_	23	amod	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	DNA	dna	NN	NN	_	27	compound	_	_
26	sequence	sequence	NN	NN	_	27	compound	_	_
27	specificity	specificity	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	cell	cell	NN	NN	_	31	dep	_	_
31	type-	type-	NN	NN	_	35	amod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	cell	cell	NN	NN	_	34	nmod:npmod	_	_
34	stage-specific	stage-specific	JJ	JJ	_	31	conj	_	_
35	distribution	distribution	NN	NN	_	23	conj	_	_
36	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	DNA	dna	NN	NN	_	8	compound	_	_
5	binding	binding	NN	NN	_	8	compound	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	dimers	dimer	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	tightly	tightly	RB	RB	_	11	advmod	_	_
11	controlled	control	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	accessory	accessory	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	called	call	VBN	VBN	_	14	acl	_	_
16	I	i	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	subunits	subunit	NNS	NNS	_	15	xcomp	_	_
20	of	of	IN	IN	_	21	case	_	_
21	which	which	WDT	WDT	_	23	nmod	_	_
22	there	there	EX	EX	_	23	expl	_	_
23	are	be	VBP	VBP	_	14	acl:relcl	_	_
24	also	also	RB	RB	_	23	advmod	_	_
25	five	five	CD	CD	_	27	nummod	_	_
26	different	different	JJ	JJ	_	27	amod	_	_
27	species	species	NNS	NNS	_	23	nsubj	_	_
28	currently	currently	RB	RB	_	29	advmod	_	_
29	known	know	VBN	VBN	_	27	acl	_	_
30	in	in	IN	IN	_	31	case	_	_
31	vertebrates	vertebrate	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	I	i	NN	NN	_	4	compound	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	5	nsubj	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	DNA	dna	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	prevent	prevent	VBP	VBP	_	5	conj	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	uptake	uptake	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	complexes	complex	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	exception	exception	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Bcl-3	bcl-3	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	0	root	_	_
7	which	which	WDT	WDT	_	11	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	addition	addition	NN	NN	_	11	nmod	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	function	function	VB	VB	_	6	acl:relcl	_	_
12	as	as	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	activating	activating	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	th	th	DT	DT	_	19	det	_	_
19	nucleus	nucleus	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Other	other	JJ	JJ	_	5	amod	_	_
2	I	i	NN	NN	_	5	compound	_	_
3	kappa	kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	8	nsubjpass	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	rather	rather	RB	RB	_	8	advmod	_	_
8	involved	involve	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	terminating	terminate	VBG	VBG	_	8	advcl	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	intracellular	intracellular	JJ	JJ	_	3	amod	_	_
3	events	event	NNS	NNS	_	22	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	lead	lead	VBP	VBP	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	inactivation	inactivation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	I	i	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	i.e.	i.e.	FW	FW	_	16	advmod	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activation	activation	NN	NN	_	3	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	3	punct	_	_
21	are	be	VBP	VBP	_	22	cop	_	_
22	complex	complex	JJ	JJ	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	involve	involve	VBP	VBP	_	0	root	_	_
3	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	proteolytic	proteolytic	JJ	JJ	_	6	amod	_	_
6	reactions	reaction	NNS	NNS	_	3	conj	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	seem	seem	VBP	VBP	_	2	conj	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	controlled	control	VBN	VBN	_	8	xcomp	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	17	nmod:poss	_	_
15	'	'	POS	POS	_	14	case	_	_
16	redox	redox	NN	NN	_	17	compound	_	_
17	status	status	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Interference	interference	NN	NN	_	12	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	activity	activity	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	beneficial	beneficial	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	suppressing	suppress	VBG	VBG	_	12	advcl	_	_
15	toxic/septic	toxic/septic	JJ	JJ	_	16	amod	_	_
16	shock	shock	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	graft-vs-host	graft-vs-host	JJ	JJ	_	19	amod	_	_
19	reactions	reaction	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	acute	acute	JJ	JJ	_	23	amod	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	reactions	reaction	NNS	NNS	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	acute	acute	JJ	JJ	_	27	amod	_	_
26	phase	phase	NN	NN	_	27	compound	_	_
27	response	response	NN	NN	_	16	conj	_	_
28	,	,	,	,	_	16	punct	_	_
29	and	and	CC	CC	_	16	cc	_	_
30	radiation	radiation	NN	NN	_	31	compound	_	_
31	damage	damage	NN	NN	_	16	conj	_	_
32	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	antioxidants	antioxidant	NNS	NNS	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	protease	protease	NN	NN	_	12	compound	_	_
12	inhibitors	inhibitor	NNS	NNS	_	8	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	provide	provide	VB	VB	_	0	root	_	_
15	a	a	DT	DT	_	17	det	_	_
16	pharmacological	pharmacological	JJ	JJ	_	17	amod	_	_
17	basis	basis	NN	NN	_	14	dobj	_	_
18	for	for	IN	IN	_	19	mark	_	_
19	interfering	interfere	VBG	VBG	_	17	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	these	these	DT	DT	_	23	det	_	_
22	acute	acute	JJ	JJ	_	23	amod	_	_
23	processes	process	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	Pentoxifylline	pentoxifylline	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	treatment	treatment	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	infection	infection	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	immunodeficiency	immunodeficiency	NN	NN	_	10	compound	_	_
10	virus	virus	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	dysregulation	dysregulation	NN	NN	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	12	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HIV-1	hiv-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	infection	infection	NN	NN	_	2	nmod	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	documented	document	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	numerous	numerous	JJ	JJ	_	18	amod	_	_
18	studies	study	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	cited	cite	VBN	VBN	_	15	conj	_	_
23	as	as	IN	IN	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	important	important	JJ	JJ	_	26	amod	_	_
26	component	component	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	pathogenesis	pathogenesis	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	this	this	DT	DT	_	33	det	_	_
32	retroviral	retroviral	JJ	JJ	_	33	amod	_	_
33	infection	infection	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	Pharmacological	pharmacological	JJ	JJ	_	2	amod	_	_
2	modification	modification	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cytokine	cytokine	NN	NN	_	5	compound	_	_
5	dysregulation	dysregulation	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	therefore	therefore	RB	RB	_	11	advmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	suggested	suggest	VBN	VBN	_	0	root	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	therapeutic	therapeutic	JJ	JJ	_	15	amod	_	_
15	modality	modality	NN	NN	_	11	nmod	_	_
16	for	for	IN	IN	_	18	case	_	_
17	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
18	infection	infection	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Dr.	Dr.	NNP	NNP	_	2	compound	_	_
2	Dezube	Dezube	NNP	NNP	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Beth	Beth	NNP	NNP	_	6	compound	_	_
5	Israel	Israel	NNP	NNP	_	6	compound	_	_
6	Hospital	Hospital	NNP	NNP	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Boston	Boston	NNP	NNP	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	concisely	concisely	RB	RB	_	11	advmod	_	_
11	reviews	review	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	state	state	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	our	we	PRP$	PRP$	_	16	nmod:poss	_	_
16	knowledge	knowledge	NN	NN	_	13	nmod	_	_
17	regarding	regard	VBG	VBG	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	effects	effect	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	pentoxifylline	pentoxifylline	NN	NN	_	19	nmod	_	_
22	on	on	IN	IN	_	23	case	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor-alpha	factor-alpha	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	a	a	DT	DT	_	30	det	_	_
30	cytokine	cytokine	NN	NN	_	27	appos	_	_
31	known	know	VBN	VBN	_	30	acl	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	influence	influence	VB	VB	_	31	ccomp	_	_
34	HIV-1	hiv-1	NN	NN	_	35	compound	_	_
35	replication	replication	NN	NN	_	33	dobj	_	_
36	and	and	CC	CC	_	33	cc	_	_
37	to	to	TO	TO	_	38	mark	_	_
38	play	play	VB	VB	_	33	conj	_	_
39	a	a	DT	DT	_	41	det	_	_
40	possible	possible	JJ	JJ	_	41	amod	_	_
41	role	role	NN	NN	_	38	dobj	_	_
42	in	in	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	clinical	clinical	JJ	JJ	_	45	amod	_	_
45	manifestations	manifestation	NNS	NNS	_	38	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	advanced	advanced	JJ	JJ	_	48	amod	_	_
48	infection	infection	NN	NN	_	45	nmod	_	_
49	with	with	IN	IN	_	51	case	_	_
50	this	this	DT	DT	_	51	det	_	_
51	virus	virus	NN	NN	_	48	nmod	_	_
52	.	.	.	.	_	11	punct	_	_

1	Pentoxifylline	pentoxifylline	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	trisubstituted	trisubstituted	JJ	JJ	_	6	amod	_	_
5	xanthine	xanthine	NN	NN	_	6	compound	_	_
6	derivative	derivative	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	1	punct	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	decrease	decrease	VB	VB	_	10	xcomp	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	viscosity	viscosity	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	is	be	VBZ	VBZ	_	19	auxpass	_	_
17	reasonably	reasonably	RB	RB	_	18	advmod	_	_
18	well	well	RB	RB	_	19	advmod	_	_
19	tolerated	tolerate	VBN	VBN	_	10	conj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	most	most	JJS	JJS	_	22	amod	_	_
22	recipients	recipient	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	drug	drug	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Results	result	NNS	NNS	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	preliminary	preliminary	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	many	many	JJ	JJ	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	6	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	conducted	conduct	VBN	VBN	_	4	acl:relcl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	Dr.	Dr.	NNP	NNP	_	13	compound	_	_
13	Dezube	Dezube	NNP	NNP	_	10	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	suggest	suggest	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	27	mark	_	_
17	use	use	NN	NN	_	27	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	agent	agent	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	combination	combination	NN	NN	_	17	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	antiretroviral	antiretroviral	JJ	JJ	_	25	amod	_	_
25	compounds	compound	NNS	NNS	_	22	nmod	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	prove	prove	VB	VB	_	15	ccomp	_	_
28	useful	useful	JJ	JJ	_	27	xcomp	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	treatment	treatment	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	patients	patient	NNS	NNS	_	31	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	HIV-1	hiv-1	NN	NN	_	36	compound	_	_
36	infection	infection	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	Gene	gene	NN	NN	_	26	nsubj	_	_
2	for	for	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	tissue-specific	tissue-specific	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EBF	ebf	NN	NN	_	6	dep	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	Olf-1	olf-1	NN	NN	_	8	conj	_	_
11	)	)	-RRB-	-RRB-	_	8	punct	_	_
12	,	,	,	,	_	1	punct	_	_
13	expressed	express	VBN	VBN	_	1	acl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	adipocytes	adipocyte	NNS	NNS	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	olfactory	olfactory	JJ	JJ	_	23	amod	_	_
23	neurons	neuron	NNS	NNS	_	17	conj	_	_
24	,	,	,	,	_	1	punct	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	located	located	JJ	JJ	_	0	root	_	_
27	on	on	IN	IN	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	chromosome	chromosome	NN	NN	_	26	nmod	_	_
30	5	5	CD	CD	_	29	nummod	_	_
31	,	,	,	,	_	29	punct	_	_
32	band	band	NN	NN	_	33	compound	_	_
33	q34	q34	NN	NN	_	29	appos	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	proximal	proximal	JJ	JJ	_	38	amod	_	_
37	mouse	mouse	NN	NN	_	38	compound	_	_
38	chromosome	chromosome	NN	NN	_	29	conj	_	_
39	11	11	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	26	punct	_	_

1	Murine	murine	NN	NN	_	3	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	adipocytes	adipocyte	NNS	NNS	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	olfactory	olfactory	JJ	JJ	_	9	amod	_	_
9	neurons	neuron	NNS	NNS	_	3	conj	_	_
10	contain	contain	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	DNA-binding	dna-binding	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	10	dobj	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	participates	participate	VBZ	VBZ	_	13	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	regulation	regulation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	encoding	encode	VBG	VBG	_	20	acl	_	_
22	tissue-specific	tissue-specific	JJ	JJ	_	23	amod	_	_
23	components	component	NNS	NNS	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	signal	signal	NN	NN	_	26	compound	_	_
26	transduction	transduction	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Purification	purification	NN	NN	_	34	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cloning	cloning	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	termed	term	VBN	VBN	_	6	acl	_	_
9	early	early	RB	RB	_	11	advmod	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	8	xcomp	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	EBF	ebf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	6	punct	_	_
16	from	from	IN	IN	_	19	case	_	_
17	murine	murine	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
20	and	and	CC	CC	_	1	cc	_	_
21	independent	independent	JJ	JJ	_	22	amod	_	_
22	cloning	cloning	NN	NN	_	1	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	protein	protein	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	termed	term	VBN	VBN	_	25	acl	_	_
28	Olf-1	olf-1	NN	NN	_	27	dobj	_	_
29	,	,	,	,	_	25	punct	_	_
30	from	from	IN	IN	_	33	case	_	_
31	olfactory	olfactory	JJ	JJ	_	33	amod	_	_
32	neuronal	neuronal	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	25	nmod	_	_
34	revealed	reveal	VBD	VBD	_	0	root	_	_
35	virtual	virtual	JJ	JJ	_	36	amod	_	_
36	complete	complete	JJ	JJ	_	40	amod	_	_
37	amino	amino	NN	NN	_	40	compound	_	_
38	acid	acid	NN	NN	_	40	compound	_	_
39	sequence	sequence	NN	NN	_	40	compound	_	_
40	identity	identity	NN	NN	_	34	dobj	_	_
41	between	between	IN	IN	_	43	case	_	_
42	these	these	DT	DT	_	43	det	_	_
43	proteins	protein	NNS	NNS	_	34	nmod	_	_
44	.	.	.	.	_	34	punct	_	_

1	As	as	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	step	step	NN	NN	_	26	nmod	_	_
5	towards	towards	IN	IN	_	6	mark	_	_
6	identifying	identify	VBG	VBG	_	4	acl	_	_
7	a	a	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	genetic	genetic	JJ	JJ	_	10	amod	_	_
10	disorder	disorder	NN	NN	_	6	dobj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	mouse	mouse	NN	NN	_	13	compound	_	_
13	mutation	mutation	NN	NN	_	10	conj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	21	nmod	_	_
16	EBF	ebf	NN	NN	_	21	nsubj	_	_
17	could	could	MD	MD	_	21	aux	_	_
18	be	be	VB	VB	_	21	cop	_	_
19	a	a	DT	DT	_	21	det	_	_
20	candidate	candidate	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	10	acl:relcl	_	_
22	,	,	,	,	_	26	punct	_	_
23	we	we	PRP	PRP	_	26	nsubj	_	_
24	have	have	VBP	VBP	_	26	aux	_	_
25	chromosomally	chromosomally	RB	RB	_	26	advmod	_	_
26	mapped	map	VBN	VBN	_	0	root	_	_
27	the	the	DT	DT	_	29	det	_	_
28	corresponding	corresponding	JJ	JJ	_	29	amod	_	_
29	locus	locus	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	both	both	DT	DT	_	32	det	_	_
32	species	species	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	26	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	Southern	southern	NN	NN	_	4	compound	_	_
3	hybridization	hybridization	NN	NN	_	4	compound	_	_
4	analyses	analysis	NNS	NNS	_	38	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	somatic	somatic	JJ	JJ	_	9	amod	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	hybrid	hybrid	NN	NN	_	9	compound	_	_
9	panels	panel	NNS	NNS	_	4	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	murine	murine	NN	NN	_	13	compound	_	_
12	cDNA	cdna	NN	NN	_	13	compound	_	_
13	probe	probe	NN	NN	_	4	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	fluorescence	fluorescence	NN	NN	_	19	compound	_	_
16	chromosomal	chromosomal	JJ	JJ	_	19	amod	_	_
17	in	in	FW	FW	_	19	amod	_	_
18	situ	situ	FW	FW	_	17	dep	_	_
19	hybridization	hybridization	NN	NN	_	4	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	FISH	fish	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	of	of	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	genomic	genomic	JJ	JJ	_	26	amod	_	_
26	clones	clone	NNS	NNS	_	19	nmod	_	_
27	,	,	,	,	_	4	punct	_	_
28	and	and	CC	CC	_	4	cc	_	_
29	analysis	analysis	NN	NN	_	4	conj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	recombinant	recombinant	JJ	JJ	_	32	amod	_	_
32	inbred	inbred	JJ	JJ	_	34	amod	_	_
33	mouse	mouse	NN	NN	_	34	compound	_	_
34	strains	strain	NNS	NNS	_	29	nmod	_	_
35	,	,	,	,	_	38	punct	_	_
36	we	we	PRP	PRP	_	38	nsubj	_	_
37	have	have	VBP	VBP	_	38	aux	_	_
38	found	find	VBN	VBN	_	0	root	_	_
39	single	single	JJ	JJ	_	40	amod	_	_
40	sites	site	NNS	NNS	_	38	dobj	_	_
41	for	for	IN	IN	_	44	case	_	_
42	EBF	ebf	NN	NN	_	44	compound	_	_
43	homologous	homologous	JJ	JJ	_	44	amod	_	_
44	sequences	sequence	NNS	NNS	_	40	nmod	_	_
45	on	on	IN	IN	_	47	case	_	_
46	human	human	JJ	JJ	_	47	amod	_	_
47	Chromosome	chromosome	NN	NN	_	40	nmod	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	Chr	chr	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	5	5	CD	CD	_	47	nummod	_	_
52	,	,	,	,	_	47	punct	_	_
53	band	band	NN	NN	_	54	compound	_	_
54	q34	q34	NN	NN	_	47	appos	_	_
55	,	,	,	,	_	47	punct	_	_
56	and	and	CC	CC	_	47	cc	_	_
57	on	on	IN	IN	_	60	case	_	_
58	proximal	proximal	JJ	JJ	_	60	amod	_	_
59	mouse	mouse	NN	NN	_	60	compound	_	_
60	Chr	chr	NN	NN	_	47	conj	_	_
61	11	11	CD	CD	_	60	nummod	_	_
62	,	,	,	,	_	40	punct	_	_
63	in	in	IN	IN	_	67	case	_	_
64	an	a	DT	DT	_	67	det	_	_
65	evolutionarily	evolutionarily	RB	RB	_	67	advmod	_	_
66	conserved	conserve	VBN	VBN	_	67	amod	_	_
67	region	region	NN	NN	_	40	nmod	_	_
68	.	.	.	.	_	38	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	interleukin	interleukin	NN	NN	_	4	compound	_	_
3	2	2	CD	CD	_	4	nummod	_	_
4	transcription	transcription	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	murine	murine	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	ciprofloxacin	ciprofloxacin	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	fluoroquinolone	fluoroquinolone	JJ	JJ	_	3	amod	_	_
3	antibiotic	antibiotic	JJ	JJ	_	10	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	ciprofloxacin	ciprofloxacin	NN	NN	_	3	appos	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	cipro	cipro	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	3	punct	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	hyperproduction	hyperproduction	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	interleukin	interleukin	NN	NN	_	11	nmod	_	_
14	2	2	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-2	il-2	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	interferon-gamma	interferon-gamma	NN	NN	_	13	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	in	in	IN	IN	_	28	case	_	_
24	stimulated	stimulate	VBN	VBN	_	28	amod	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
27	blood	blood	NN	NN	_	28	compound	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	investigation	investigation	NN	NN	_	15	nmod	_	_
4	an	a	DT	DT	_	12	det	_	_
5	enhanced	enhance	VBN	VBN	_	12	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	prolonged	prolonged	JJ	JJ	_	5	conj	_	_
8	IL-2	il-2	NN	NN	_	12	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	8	conj	_	_
12	response	response	NN	NN	_	15	nsubjpass	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	detected	detect	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	15	nmod	_	_
17	both	both	CC	CC	_	16	dep	_	_
18	stimulated	stimulate	VBN	VBN	_	27	amod	_	_
19	(	(	-LRB-	-LRB-	_	18	punct	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cell	cell	NN	NN	_	18	dep	_	_
22	mitogens	mitogen	NNS	NNS	_	21	dep	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	alloantigens	alloantigen	NNS	NNS	_	22	conj	_	_
25	)	)	-RRB-	-RRB-	_	18	punct	_	_
26	murine	murine	JJ	JJ	_	27	amod	_	_
27	splenocytes	splenocyte	NNS	NNS	_	16	conj	_	_
28	and	and	CC	CC	_	16	cc	_	_
29	in	in	IN	IN	_	36	case	_	_
30	the	the	DT	DT	_	36	det	_	_
31	stimulated	stimulate	VBN	VBN	_	36	amod	_	_
32	murine	murine	JJ	JJ	_	36	amod	_	_
33	T	t	NN	NN	_	36	compound	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	line	line	NN	NN	_	36	compound	_	_
36	EL-4	el-4	NN	NN	_	16	conj	_	_
37	in	in	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	dep	_	_
39	presence	presence	NN	NN	_	41	dep	_	_
40	of	of	IN	IN	_	41	case	_	_
41	ciprofloxacin	ciprofloxacin	NN	NN	_	15	nmod	_	_
42	(	(	-LRB-	-LRB-	_	44	punct	_	_
43	5-80	5-80	CD	CD	_	44	nummod	_	_
44	micrograms/ml	micrograms/ml	NN	NN	_	41	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	as	as	IN	IN	_	47	mark	_	_
47	compared	compare	VBN	VBN	_	15	advcl	_	_
48	to	to	TO	TO	_	50	case	_	_
49	control	control	NN	NN	_	50	compound	_	_
50	cells	cell	NNS	NNS	_	47	nmod	_	_
51	without	without	IN	IN	_	52	case	_	_
52	antibiotics	antibiotic	NNS	NNS	_	50	nmod	_	_
53	.	.	.	.	_	15	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	in	in	IN	IN	_	7	case	_	_
4	contrast	contrast	NN	NN	_	7	dep	_	_
5	to	to	TO	TO	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	10	compound	_	_
10	production	production	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	aux	_	_
18	unaffected	unaffected	JJ	JJ	_	12	conj	_	_
19	at	at	IN	IN	_	21	case	_	_
20	24	24	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	only	only	RB	RB	_	24	advmod	_	_
24	slightly	slightly	RB	RB	_	25	advmod	_	_
25	upregulated	upregulate	VBN	VBN	_	18	conj	_	_
26	at	at	IN	IN	_	30	case	_	_
27	48	48	CD	CD	_	30	nummod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	72	72	CD	CD	_	27	conj	_	_
30	h	h	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	culture	culture	NN	NN	_	18	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	murine	murine	JJ	JJ	_	35	amod	_	_
35	splenocytes	splenocyte	NNS	NNS	_	18	nmod	_	_
36	incubated	incubate	VBN	VBN	_	35	acl	_	_
37	with	with	IN	IN	_	38	case	_	_
38	cipro	cipro	NN	NN	_	36	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	20	20	CD	CD	_	41	nummod	_	_
41	micrograms/ml	micrograms/ml	NNS	NNS	_	38	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	12	punct	_	_

1	EL-4	el-4	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	transfected	transfect	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	plasmid	plasmid	NN	NN	_	4	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	14	det	_	_
10	IL-2	il-2	NN	NN	_	14	compound	_	_
11	promoter	promoter	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	enhancer	enhancer	NN	NN	_	11	conj	_	_
14	region	region	NN	NN	_	8	dobj	_	_
15	linked	link	VBN	VBN	_	14	acl	_	_
16	to	to	TO	TO	_	24	case	_	_
17	the	the	DT	DT	_	24	det	_	_
18	chloramphenicol	chloramphenicol	NN	NN	_	19	compound	_	_
19	acetyltransferase	acetyltransferase	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CAT	cat	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	reporter	reporter	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CAT	cat	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	cipro	cipro	NN	NN	_	8	nsubj	_	_
8	enhanced	enhance	VBD	VBD	_	5	ccomp	_	_
9	IL-2	il-2	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	EL-4	el-4	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	9	nsubj	_	_
6	incubated	incubate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	ciprofloxacin	ciprofloxacin	NN	NN	_	6	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	an	a	DT	DT	_	12	det	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	peak	peak	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NFAT-1	nfat-1	NN	NN	_	17	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	as	as	IN	IN	_	26	mark	_	_
26	compared	compare	VBN	VBN	_	9	advcl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	control	control	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	without	without	IN	IN	_	31	case	_	_
31	antibiotics	antibiotic	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Cipro	cipro	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	affect	affect	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	dobj	_	_
9	AP-1	ap-1	NN	NN	_	8	dep	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	NFIL-2A	nfil-2a	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	5	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	cipro	cipro	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	5	punct	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	enhanced	enhance	VBD	VBD	_	5	conj	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	murine	murine	JJ	JJ	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	means	means	NNS	NNS	_	19	dep	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	influencing	influence	VBG	VBG	_	10	advcl	_	_
20	NFAT-1	nfat-1	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	causing	cause	VBG	VBG	_	19	conj	_	_
23	an	a	DT	DT	_	26	det	_	_
24	increased	increase	VBN	VBN	_	26	amod	_	_
25	IL-2	il-2	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Multiple	multiple	JJ	JJ	_	3	amod	_	_
2	prolactin-responsive	prolactin-responsive	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	4	nsubj	_	_
4	mediate	mediate	VBP	VBP	_	0	root	_	_
5	G1	g1	NN	NN	_	9	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	S	s	NN	NN	_	5	conj	_	_
8	phase	phase	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	interferon	interferon	NN	NN	_	15	compound	_	_
13	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
14	factor-1	factor-1	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	interferon	interferon	NN	NN	_	4	compound	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	factor-1	factor-1	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IRF-1	irf-1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	gene	gene	NN	NN	_	15	nsubj	_	_
9	is	be	VBZ	VBZ	_	15	cop	_	_
10	both	both	CC	CC	_	15	cc:preconj	_	_
11	an	a	DT	DT	_	15	det	_	_
12	immediate-early	immediate-early	JJ	JJ	_	15	amod	_	_
13	G1	g1	NN	NN	_	15	compound	_	_
14	phase	phase	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	an	a	DT	DT	_	20	det	_	_
18	S	s	NN	NN	_	20	compound	_	_
19	phase	phase	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	conj	_	_
21	inducible	inducible	JJ	JJ	_	15	amod	_	_
22	by	by	IN	IN	_	23	case	_	_
23	PRL	prl	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	rat	rat	NN	NN	_	28	compound	_	_
26	Nb2	nb2	NN	NN	_	28	compound	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	16	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	PRL	prl	NN	NN	_	8	nsubj	_	_
8	regulates	regulate	VBZ	VBZ	_	4	acl:relcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	biphasic	biphasic	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IRF-1	irf-1	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	cloned	clone	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	20	det	_	_
18	rat	rat	NN	NN	_	20	compound	_	_
19	IRF-1	irf-1	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	dobj	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	functionally	functionally	RB	RB	_	23	advmod	_	_
23	characterized	characterize	VBD	VBD	_	16	conj	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IRF-1	irf-1	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	16	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	transfection	transfection	NN	NN	_	28	nmod	_	_
3	into	into	IN	IN	_	6	case	_	_
4	Nb2	nb2	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	28	punct	_	_
8	1.7	1.7	CD	CD	_	9	nummod	_	_
9	kilobases	kilobase	NNS	NNS	_	28	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	kb	kb	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	of	of	IN	IN	_	16	case	_	_
14	IRF-1	irf-1	NN	NN	_	16	compound	_	_
15	5'-flanking	5'-flanking	JJ	JJ	_	16	amod	_	_
16	DNA	dna	NN	NN	_	9	nmod	_	_
17	linked	link	VBN	VBN	_	16	acl	_	_
18	to	to	TO	TO	_	27	case	_	_
19	a	a	DT	DT	_	27	det	_	_
20	chloramphenicol	chloramphenicol	NN	NN	_	22	compound	_	_
21	acetyl	acetyl	JJ	JJ	_	22	amod	_	_
22	transferase	transferase	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CAT	cat	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	reporter	reporter	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	17	nmod	_	_
28	mediated	mediate	VBD	VBD	_	0	root	_	_
29	a	a	DT	DT	_	31	det	_	_
30	30-fold	30-fold	JJ	JJ	_	31	amod	_	_
31	induction	induction	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	CAT	cat	NN	NN	_	35	compound	_	_
34	enzyme	enzyme	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	31	nmod	_	_
36	in	in	IN	IN	_	40	case	_	_
37	response	response	NN	NN	_	40	dep	_	_
38	to	to	TO	TO	_	40	case	_	_
39	24	24	CD	CD	_	40	nummod	_	_
40	h	h	NN	NN	_	28	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	PRL	prl	NN	NN	_	43	compound	_	_
43	stimulation	stimulation	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	28	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	mutants	mutant	NNS	NNS	_	17	nsubj	_	_
3	containing	contain	VBG	VBG	_	2	acl	_	_
4	1.3	1.3	CD	CD	_	6	nummod	_	_
5	,	,	,	,	_	6	punct	_	_
6	0.6	0.6	CD	CD	_	10	dep	_	_
7	,	,	,	,	_	6	punct	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	0.2	0.2	CD	CD	_	6	conj	_	_
10	kb	kb	NN	NN	_	12	dep	_	_
11	5'-flanking	5'-flanking	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	3	dobj	_	_
13	were	be	VBD	VBD	_	17	cop	_	_
14	incrementally	incrementally	RB	RB	_	17	advmod	_	_
15	less	less	RBR	RBR	_	16	advmod	_	_
16	transcriptionally	transcriptionally	RB	RB	_	14	advmod	_	_
17	active	active	JJ	JJ	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	although	although	IN	IN	_	23	mark	_	_
20	0.2	0.2	CD	CD	_	21	nummod	_	_
21	kb	kb	NN	NN	_	23	nsubj	_	_
22	still	still	RB	RB	_	23	advmod	_	_
23	mediated	mediate	VBD	VBD	_	17	advcl	_	_
24	a	a	DT	DT	_	26	det	_	_
25	12-fold	12-fold	JJ	JJ	_	26	amod	_	_
26	induction	induction	NN	NN	_	23	dobj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	PRL	prl	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	15	nsubj	_	_
3	between	between	IN	IN	_	7	case	_	_
4	-1.7	-1.7	CD	CD	_	7	nummod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	-0.2	-0.2	CD	CD	_	4	conj	_	_
7	kb	kb	NN	NN	_	2	nmod	_	_
8	linked	link	VBN	VBN	_	2	acl	_	_
9	to	to	TO	TO	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	heterologous	heterologous	JJ	JJ	_	14	amod	_	_
12	thymidine	thymidine	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	8	nmod	_	_
15	failed	fail	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	respond	respond	VB	VB	_	15	xcomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	PRL	prl	NN	NN	_	20	compound	_	_
20	stimulation	stimulation	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	suggesting	suggest	VBG	VBG	_	15	xcomp	_	_
23	that	that	IN	IN	_	32	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	activity	activity	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	upstream	upstream	JJ	JJ	_	30	amod	_	_
28	PRL	prl	NN	NN	_	30	compound	_	_
29	response	response	NN	NN	_	30	compound	_	_
30	elements	element	NNS	NNS	_	25	nmod	_	_
31	may	may	MD	MD	_	32	aux	_	_
32	require	require	VB	VB	_	22	ccomp	_	_
33	an	a	DT	DT	_	34	det	_	_
34	interaction	interaction	NN	NN	_	32	dobj	_	_
35	with	with	IN	IN	_	37	case	_	_
36	promoter-proximal	promoter-proximal	JJ	JJ	_	37	amod	_	_
37	elements	element	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	assaying	assay	VBG	VBG	_	16	advcl	_	_
3	CAT	cat	NN	NN	_	5	compound	_	_
4	enzyme	enzyme	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	across	across	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	24-h	24-h	JJ	JJ	_	12	amod	_	_
9	PRL	prl	NN	NN	_	12	compound	_	_
10	induction	induction	NN	NN	_	12	compound	_	_
11	time	time	NN	NN	_	12	compound	_	_
12	course	course	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	able	able	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	assign	assign	VB	VB	_	16	xcomp	_	_
19	G1	g1	NN	NN	_	24	compound	_	_
20	vs.	vs.	CC	CC	_	19	cc	_	_
21	S	s	NN	NN	_	19	conj	_	_
22	phase	phase	NN	NN	_	24	compound	_	_
23	PRL	prl	NN	NN	_	24	compound	_	_
24	responses	response	NNS	NNS	_	18	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	IRF-1	irf-1	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	24	nmod	_	_
29	to	to	TO	TO	_	31	case	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	regions	region	NNS	NNS	_	18	nmod	_	_
32	of	of	IN	IN	_	38	case	_	_
33	the	the	DT	DT	_	38	det	_	_
34	IRF-1	irf-1	NN	NN	_	38	compound	_	_
35	5'-flanking	5'-flanking	JJ	JJ	_	38	amod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	promoter	promoter	NN	NN	_	35	conj	_	_
38	DNA	dna	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	0.2-kb	0.2-kb	JJ	JJ	_	4	amod	_	_
3	IRF-CAT	irf-cat	NN	NN	_	4	compound	_	_
4	construct	construct	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	PRL	prl	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	6	nmod	_	_
10	during	during	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	G1	g1	NN	NN	_	13	compound	_	_
13	phase	phase	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	cycle	cycle	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	1.7-kb	1.7-kb	JJ	JJ	_	7	amod	_	_
6	IRF-CAT	irf-cat	NN	NN	_	7	compound	_	_
7	construct	construct	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	inducible	inducible	JJ	JJ	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	PRL	prl	NN	NN	_	9	nmod	_	_
12	during	during	IN	IN	_	17	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	G1	g1	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	S	s	NN	NN	_	14	conj	_	_
17	phase	phase	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	cycle	cycle	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Hence	hence	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	PRL-induced	prl-induced	JJ	JJ	_	6	amod	_	_
5	biphasic	biphasic	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IRF-1	irf-1	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	appears	appear	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	controlled	control	VBN	VBN	_	11	xcomp	_	_
15	by	by	IN	IN	_	18	case	_	_
16	separate	separate	JJ	JJ	_	18	amod	_	_
17	PRL-responsive	prl-responsive	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	14	nmod	_	_
19	:	:	:	:	_	11	punct	_	_
20	elements	element	NNS	NNS	_	31	nsubj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	first	first	JJ	JJ	_	25	amod	_	_
24	0.2	0.2	CD	CD	_	25	nummod	_	_
25	kb	kb	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	IRF-1	irf-1	NN	NN	_	30	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	region	region	NN	NN	_	25	nmod	_	_
31	act	act	VBP	VBP	_	11	parataxis	_	_
32	during	during	IN	IN	_	34	case	_	_
33	early	early	JJ	JJ	_	34	amod	_	_
34	activation	activation	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	31	punct	_	_
36	and	and	CC	CC	_	31	cc	_	_
37	elements	element	NNS	NNS	_	43	nsubj	_	_
38	between	between	IN	IN	_	42	case	_	_
39	0.2	0.2	CD	CD	_	42	nummod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	1.7	1.7	CD	CD	_	39	conj	_	_
42	kb	kb	NN	NN	_	37	nmod	_	_
43	act	act	VBP	VBP	_	31	conj	_	_
44	in	in	IN	IN	_	50	case	_	_
45	concert	concert	NN	NN	_	50	dep	_	_
46	with	with	IN	IN	_	50	case	_	_
47	the	the	DT	DT	_	50	det	_	_
48	proximal	proximal	JJ	JJ	_	50	amod	_	_
49	0.2-kb	0.2-kb	JJ	JJ	_	50	amod	_	_
50	region	region	NN	NN	_	43	nmod	_	_
51	during	during	IN	IN	_	54	case	_	_
52	S	s	NN	NN	_	54	compound	_	_
53	phase	phase	NN	NN	_	54	compound	_	_
54	progression	progression	NN	NN	_	43	nmod	_	_
55	.	.	.	.	_	11	punct	_	_

1	Nonpituitary	nonpituitary	JJ	JJ	_	5	amod	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	prolactin	prolactin	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	independent	independent	JJ	JJ	_	0	root	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Pit-1	pit-1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	differentially	differentially	RB	RB	_	7	advmod	_	_
12	controlled	control	VBN	VBN	_	7	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	in	in	IN	IN	_	18	case	_	_
17	endometrial	endometrial	JJ	JJ	_	18	amod	_	_
18	stroma	stroma	NN	NN	_	14	conj	_	_
19	.	.	.	.	_	7	punct	_	_

1	Expression	expression	NN	NN	_	31	nsubjpass	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	PRL	prl	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	hPRL	hprl	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	gene	gene	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	extrapituitary	extrapituitary	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	1	nmod	_	_
13	such	such	JJ	JJ	_	16	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	the	the	DT	DT	_	16	det	_	_
16	uterus	uterus	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	decidualized	decidualize	VBN	VBN	_	20	amod	_	_
19	endometrial	endometrial	JJ	JJ	_	20	amod	_	_
20	stroma	stroma	NN	NN	_	16	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	myometrium	myometrium	NN	NN	_	20	conj	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	cells	cell	NNS	NNS	_	16	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
29	lineage	lineage	NN	NN	_	25	nmod	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	directed	direct	VBN	VBN	_	0	root	_	_
32	by	by	IN	IN	_	35	case	_	_
33	an	a	DT	DT	_	35	det	_	_
34	alternative	alternative	JJ	JJ	_	35	amod	_	_
35	promoter	promoter	NN	NN	_	31	nmod	_	_
36	which	which	WDT	WDT	_	38	nsubj	_	_
37	is	be	VBZ	VBZ	_	38	cop	_	_
38	located	located	JJ	JJ	_	35	acl:relcl	_	_
39	approximately	approximately	RB	RB	_	43	advmod	_	_
40	6	6	CD	CD	_	43	nummod	_	_
41	kilobases	kilobase	NNS	NNS	_	43	compound	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	kb	kb	NN	NN	_	45	nmod:npmod	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	upstream	upstream	RB	RB	_	38	advmod	_	_
46	of	of	IN	IN	_	50	case	_	_
47	the	the	DT	DT	_	50	det	_	_
48	pituitary-specific	pituitary-specific	JJ	JJ	_	50	amod	_	_
49	start	start	NN	NN	_	50	compound	_	_
50	site	site	NN	NN	_	45	nmod	_	_
51	.	.	.	.	_	31	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	delineate	delineate	VB	VB	_	19	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	tissue-specific	tissue-specific	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
8	governing	govern	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	control	control	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	nonpituitary	nonpituitary	JJ	JJ	_	15	amod	_	_
13	PRL	prl	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	cloned	clone	VBN	VBN	_	0	root	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	sequenced	sequence	VBN	VBN	_	19	conj	_	_
22	3	3	CD	CD	_	25	nummod	_	_
23	kb	kb	NN	NN	_	25	compound	_	_
24	5'-flanking	5'-flanking	JJ	JJ	_	25	amod	_	_
25	DNA	dna	NN	NN	_	19	dobj	_	_
26	of	of	IN	IN	_	33	case	_	_
27	the	the	DT	DT	_	33	det	_	_
28	upstream	upstream	JJ	JJ	_	33	amod	_	_
29	decidual/lymphoid	decidual/lymphoid	JJ	JJ	_	33	amod	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	dPRL	dprl	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	promoter	promoter	NN	NN	_	25	nmod	_	_
34	.	.	.	.	_	19	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	homology	homology	NN	NN	_	6	advcl	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	binding	bind	VBG	VBG	_	9	amod	_	_
9	motifs	motif	NNS	NNS	_	6	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	Pit-1	pit-1	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	seven	seven	CD	CD	_	14	nummod	_	_
14	half-sites	half-site	NNS	NNS	_	9	conj	_	_
15	for	for	IN	IN	_	22	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
17	receptor/progesterone	receptor/progesterone	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PR	pr	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	binding	binding	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	focused	focus	VBD	VBD	_	0	root	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	studies	study	NNS	NNS	_	2	dobj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Pit-1	pit-1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	of	of	IN	IN	_	12	case	_	_
12	PR	pr	NN	NN	_	9	conj	_	_
13	as	as	IN	IN	_	16	case	_	_
14	potential	potential	JJ	JJ	_	16	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	regulators	regulator	NNS	NNS	_	7	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	since	since	IN	IN	_	25	mark	_	_
19	the	the	DT	DT	_	22	det	_	_
20	POU	pou	NN	NN	_	22	compound	_	_
21	domain	domain	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	25	nsubj	_	_
23	Pit-1	pit-1	NN	NN	_	22	dep	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	essential	essential	JJ	JJ	_	2	advcl	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	control	control	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	pituitary	pituitary	JJ	JJ	_	32	amod	_	_
31	PRL	prl	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	25	punct	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	progesterone	progesterone	NN	NN	_	36	nsubj	_	_
36	induces	induce	VBZ	VBZ	_	25	conj	_	_
37	decidual	decidual	JJ	JJ	_	38	amod	_	_
38	transformation	transformation	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	endometrial	endometrial	JJ	JJ	_	42	amod	_	_
42	stroma	stroma	NN	NN	_	38	nmod	_	_
43	,	,	,	,	_	38	punct	_	_
44	a	a	DT	DT	_	46	det	_	_
45	differentiation	differentiation	NN	NN	_	46	compound	_	_
46	process	process	NN	NN	_	38	appos	_	_
47	during	during	IN	IN	_	48	case	_	_
48	which	which	WDT	WDT	_	54	nmod	_	_
49	the	the	DT	DT	_	52	det	_	_
50	decidual	decidual	JJ	JJ	_	52	amod	_	_
51	PRL	prl	NN	NN	_	52	compound	_	_
52	gene	gene	NN	NN	_	54	nsubjpass	_	_
53	is	be	VBZ	VBZ	_	54	auxpass	_	_
54	activated	activate	VBN	VBN	_	46	acl:relcl	_	_
55	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	variety	variety	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	types	type	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	endometrial	endometrial	JJ	JJ	_	14	amod	_	_
14	stroma	stroma	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	2	punct	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	Pit-1	pit-1	NN	NN	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	involved	involve	VBN	VBN	_	2	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	dPRL	dprl	NN	NN	_	28	compound	_	_
26	promoter/reporter	promoter/reporter	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	constructs	construct	NNS	NNS	_	23	nmod	_	_
29	carrying	carry	VBG	VBG	_	28	acl	_	_
30	3	3	CD	CD	_	33	nummod	_	_
31	kb	kb	NN	NN	_	33	compound	_	_
32	5'-flanking	5'-flanking	JJ	JJ	_	33	amod	_	_
33	DNA	dna	NN	NN	_	29	dobj	_	_
34	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	PR	pr	NN	NN	_	10	nsubj	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	confer	confer	VB	VB	_	4	ccomp	_	_
11	direct	direct	JJ	JJ	_	13	amod	_	_
12	transcriptional	transcriptional	JJ	JJ	_	11	dep	_	_
13	control	control	NN	NN	_	10	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	dPRL	dprl	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	compared	compare	VBD	VBD	_	19	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transfected	transfect	VBN	VBN	_	10	amod	_	_
9	dPRL	dprl	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	PRL-secreting	prl-secreting	JJ	JJ	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	nonsecreting	nonsecreting	JJ	JJ	_	12	conj	_	_
15	lymphoid	lymphoid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	dep	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	found	find	VBD	VBD	_	0	root	_	_
20	that	that	IN	IN	_	32	mark	_	_
21	the	the	DT	DT	_	25	det	_	_
22	3	3	CD	CD	_	25	nummod	_	_
23	kb	kb	NN	NN	_	25	compound	_	_
24	5'-flanking	5'-flanking	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	dPRL	dprl	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	did	do	VBD	VBD	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	contain	contain	VB	VB	_	19	ccomp	_	_
33	elements	element	NNS	NNS	_	32	dobj	_	_
34	restricting	restrict	VBG	VBG	_	33	acl	_	_
35	expression	expression	NN	NN	_	34	dobj	_	_
36	to	to	TO	TO	_	39	case	_	_
37	only	only	RB	RB	_	39	advmod	_	_
38	those	those	DT	DT	_	39	det	_	_
39	lymphocytes	lymphocyte	NNS	NNS	_	34	nmod	_	_
40	that	that	WDT	WDT	_	41	nsubj	_	_
41	produce	produce	VBP	VBP	_	39	acl:relcl	_	_
42	PRL	prl	NN	NN	_	41	dobj	_	_
43	but	but	CC	CC	_	32	cc	_	_
44	allowed	allow	VBD	VBD	_	32	conj	_	_
45	expression	expression	NN	NN	_	44	dobj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	fusion	fusion	NN	NN	_	49	compound	_	_
48	reporter	reporter	NN	NN	_	49	compound	_	_
49	genes	gene	NNS	NNS	_	45	nmod	_	_
50	irrespective	irrespective	JJ	JJ	_	49	amod	_	_
51	of	of	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	status	status	NN	NN	_	50	nmod	_	_
54	of	of	IN	IN	_	58	case	_	_
55	the	the	DT	DT	_	58	det	_	_
56	endogenous	endogenous	JJ	JJ	_	58	amod	_	_
57	PRL	prl	NN	NN	_	58	compound	_	_
58	gene	gene	NN	NN	_	53	nmod	_	_
59	.	.	.	.	_	19	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	was	be	VBD	VBD	_	5	cop	_	_
3	in	in	IN	IN	_	5	case	_	_
4	sharp	sharp	JJ	JJ	_	5	amod	_	_
5	contrast	contrast	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	endometrial	endometrial	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	where	where	WRB	WRB	_	14	advmod	_	_
10	3	3	CD	CD	_	13	nummod	_	_
11	kb	kb	NN	NN	_	13	compound	_	_
12	5'-flanking	5'-flanking	JJ	JJ	_	13	amod	_	_
13	DNA	dna	NN	NN	_	14	nsubj	_	_
14	conferred	confer	VBD	VBD	_	8	acl:relcl	_	_
15	strong	strong	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	15	dep	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	on	on	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	dPRL	dprl	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	14	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	decidualized	decidualize	VBN	VBN	_	26	amod	_	_
24	endometrial	endometrial	JJ	JJ	_	26	amod	_	_
25	stromal	stromal	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	actively	actively	RB	RB	_	28	advmod	_	_
28	secreting	secrete	VBG	VBG	_	26	acl	_	_
29	PRL	prl	NN	NN	_	28	dobj	_	_
30	,	,	,	,	_	14	punct	_	_
31	but	but	CC	CC	_	14	cc	_	_
32	did	do	VBD	VBD	_	34	aux	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	allow	allow	VB	VB	_	14	conj	_	_
35	transcription	transcription	NN	NN	_	34	dobj	_	_
36	in	in	IN	IN	_	41	case	_	_
37	undifferentiated	undifferentiated	JJ	JJ	_	41	amod	_	_
38	non-PRL-secreting	non-prl-secreting	JJ	JJ	_	41	amod	_	_
39	endometrial	endometrial	JJ	JJ	_	41	amod	_	_
40	stromal	stromal	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	35	nmod	_	_
42	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	dPRL	dprl	NN	NN	_	6	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	construct	construct	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	these	these	DT	DT	_	10	det	_	_
9	undifferentiated	undifferentiated	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	could	could	MD	MD	_	14	aux	_	_
12	however	however	RB	RB	_	14	advmod	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	addition	addition	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cAMP	camp	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	absence	absence	NN	NN	_	14	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	progesterone	progesterone	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	suggesting	suggest	VBG	VBG	_	14	advcl	_	_
28	that	that	IN	IN	_	40	mark	_	_
29	a	a	DT	DT	_	30	det	_	_
30	signal	signal	NN	NN	_	40	nsubj	_	_
31	transduced	transduce	VBN	VBN	_	30	acl	_	_
32	through	through	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	cAMP	camp	NN	NN	_	36	compound	_	_
35	signaling	signaling	NN	NN	_	36	compound	_	_
36	pathway	pathway	NN	NN	_	31	nmod	_	_
37	is	be	VBZ	VBZ	_	40	cop	_	_
38	a	a	DT	DT	_	40	det	_	_
39	primary	primary	JJ	JJ	_	40	amod	_	_
40	inducer	inducer	NN	NN	_	27	ccomp	_	_
41	of	of	IN	IN	_	45	case	_	_
42	decidual	decidual	JJ	JJ	_	45	amod	_	_
43	PRL	prl	NN	NN	_	45	compound	_	_
44	gene	gene	NN	NN	_	45	compound	_	_
45	expression	expression	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	14	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	early	early	JJ	JJ	_	8	amod	_	_
4	growth	growth	NN	NN	_	8	compound	_	_
5	response	response	NN	NN	_	8	compound	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	pp90rsk	pp90rsk	NN	NN	_	8	conj	_	_
11	during	during	IN	IN	_	12	case	_	_
12	induction	induction	NN	NN	_	1	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	5	nsubj	_	_
4	has	have	VBZ	VBZ	_	5	aux	_	_
5	studied	study	VBN	VBN	_	0	root	_	_
6	mechanisms	mechanism	NNS	NNS	_	5	dobj	_	_
7	responsible	responsible	JJ	JJ	_	6	amod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	induction	induction	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	19	case	_	_
11	early	early	JJ	JJ	_	19	amod	_	_
12	growth	growth	NN	NN	_	19	compound	_	_
13	response	response	NN	NN	_	19	compound	_	_
14	1	1	CD	CD	_	19	nummod	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	EGR-1	egr-1	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	9	nmod	_	_
20	during	during	IN	IN	_	22	case	_	_
21	monocytic	monocytic	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	9	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	U-937	u-937	NN	NN	_	27	compound	_	_
25	myeloid	myeloid	JJ	JJ	_	27	amod	_	_
26	leukemia	leukemia	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Differentiation	differentiation	NN	NN	_	21	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	U-937	u-937	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TPA	tpa	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	an	a	DT	DT	_	12	det	_	_
12	activator	activator	NN	NN	_	6	appos	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	serine/threonine	serine/threonine	NN	NN	_	18	compound	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	1	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	associated	associate	VBN	VBN	_	0	root	_	_
22	with	with	IN	IN	_	24	case	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	EGR-1	egr-1	NN	NN	_	28	compound	_	_
27	promoter-reporter	promoter-reporter	JJ	JJ	_	28	amod	_	_
28	constructs	construct	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	EGR-1	egr-1	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	six	six	CD	CD	_	10	nummod	_	_
6	CC(A/T)6GG	cc(a/t)6gg	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CArG	carg	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	motifs	motif	NNS	NNS	_	4	dobj	_	_
11	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	5'-most	5'-most	JJ	JJ	_	6	amod	_	_
4	distal	distal	JJ	JJ	_	6	amod	_	_
5	CArG	carg	NN	NN	_	6	compound	_	_
6	sequences	sequence	NNS	NNS	_	7	nsubj	_	_
7	conferred	confer	VBD	VBD	_	0	root	_	_
8	TPA	tpa	NN	NN	_	9	compound	_	_
9	inducibility	inducibility	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	little	little	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	5	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TPA	tpa	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	EGR-1	egr-1	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	TPA-resistant	tpa-resistant	JJ	JJ	_	18	amod	_	_
16	U-937	u-937	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	variant	variant	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	designated	designate	VBN	VBN	_	18	acl	_	_
21	TUR	tur	NN	NN	_	20	xcomp	_	_
22	.	.	.	.	_	5	punct	_	_

1	Treatment	treatment	NN	NN	_	23	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	U-937	u-937	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TUR	tur	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	conj	_	_
8	with	with	IN	IN	_	10	case	_	_
9	okadaic	okadaic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	17	case	_	_
15	serine/threonine	serine/threonine	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	phosphatases	phosphatase	NNS	NNS	_	13	nmod	_	_
18	1	1	CD	CD	_	17	dep	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	2A	2a	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	1	punct	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	associated	associate	VBN	VBN	_	0	root	_	_
24	with	with	IN	IN	_	25	case	_	_
25	induction	induction	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	monocytic	monocytic	JJ	JJ	_	28	amod	_	_
28	differentiation	differentiation	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	EGR-1	egr-1	NN	NN	_	31	compound	_	_
31	transcription	transcription	NN	NN	_	28	conj	_	_
32	through	through	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	5'-most	5'-most	JJ	JJ	_	36	amod	_	_
35	CArG	carg	NN	NN	_	36	compound	_	_
36	element	element	NN	NN	_	28	nmod	_	_
37	.	.	.	.	_	23	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	findings	finding	NNS	NNS	_	4	nsubj	_	_
4	supported	support	VBD	VBD	_	19	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	involvement	involvement	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	serine/threonine	serine/threonine	NN	NN	_	10	compound	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	EGR-1	egr-1	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	studied	study	VBD	VBD	_	0	root	_	_
20	activation	activation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	28	case	_	_
22	the	the	DT	DT	_	28	det	_	_
23	40S	40s	NN	NN	_	28	compound	_	_
24	ribosomal	ribosomal	JJ	JJ	_	28	amod	_	_
25	protein	protein	NN	NN	_	28	compound	_	_
26	S6	s6	NN	NN	_	28	compound	_	_
27	serine/threonine	serine/threonine	NN	NN	_	28	compound	_	_
28	kinases	kinase	NNS	NNS	_	20	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	pp70S6K	pp70s6k	NN	NN	_	28	appos	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	pp90rsk	pp90rsk	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	19	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	both	both	DT	DT	_	3	det	_	_
3	kinases	kinase	NNS	NNS	_	4	nsubj	_	_
4	participate	participate	VBP	VBP	_	11	advcl	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	regulating	regulate	VBG	VBG	_	4	advcl	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	growth	growth	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	11	punct	_	_
10	there	there	EX	EX	_	11	expl	_	_
11	was	be	VBD	VBD	_	0	root	_	_
12	no	no	DT	DT	_	14	neg	_	_
13	detectable	detectable	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	11	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	pp70S6K	pp70s6k	NN	NN	_	14	nmod	_	_
17	during	during	IN	IN	_	18	case	_	_
18	TPA-	tpa-	NN	NN	_	14	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	okadaic	okadaic	JJ	JJ	_	21	amod	_	_
21	acid-induced	acid-induced	JJ	JJ	_	18	conj	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	18	dep	_	_
24	.	.	.	.	_	11	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	rapamycin	rapamycin	NN	NN	_	11	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	an	a	DT	DT	_	6	det	_	_
6	inhibitor	inhibitor	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	9	case	_	_
8	pp70S6K	pp70s6k	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	had	have	VBD	VBD	_	0	root	_	_
12	no	no	DT	DT	_	13	neg	_	_
13	effect	effect	NN	NN	_	11	dobj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	induction	induction	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	EGR-1	egr-1	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	analysis	analysis	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	pp90rsk	pp90rsk	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	peptide	peptide	NN	NN	_	9	nmod	_	_
13	derived	derive	VBN	VBN	_	12	acl	_	_
14	from	from	IN	IN	_	16	case	_	_
15	S6	s6	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
18	stimulation	stimulation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	kinase	kinase	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	TPA-treated	tpa-treated	JJ	JJ	_	24	amod	_	_
24	U-937	u-937	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	TUR	tur	NN	NN	_	24	conj	_	_
29	,	,	,	,	_	24	punct	_	_
30	cells	cell	NNS	NNS	_	24	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	3	amod	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	both	both	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	types	type	NNS	NNS	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	pp90rsk	pp90rsk	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	prostaglandin	prostaglandin	NN	NN	_	4	compound	_	_
4	E2	e2	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	10	case	_	_
6	Th0-type	th0-type	JJ	JJ	_	10	amod	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	clones	clone	NNS	NNS	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	modulation	modulation	NN	NN	_	1	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	functions	function	NNS	NNS	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	proteins	protein	NNS	NNS	_	14	nmod	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	24	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	prostaglandin	prostaglandin	NN	NN	_	5	compound	_	_
5	E2	e2	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PGE2	pge2	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	on	on	IN	IN	_	10	case	_	_
10	cytokine	cytokine	NN	NN	_	2	nmod	_	_
11	production	production	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	proliferation	proliferation	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
17	human	human	JJ	JJ	_	22	amod	_	_
18	helper	helper	NN	NN	_	22	compound	_	_
19	T	t	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	clone	clone	NN	NN	_	22	compound	_	_
22	SP-B21	sp-b21	NN	NN	_	10	nmod	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	investigated	investigate	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	cells	cell	NNS	NNS	_	9	nmod	_	_
3	stimulated	stimulate	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	6	case	_	_
5	anti-CD3	anti-cd3	JJ	JJ	_	6	amod	_	_
6	mAb	mab	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	PGE2	pge2	NN	NN	_	9	nsubj	_	_
9	inhibited	inhibit	VBD	VBD	_	0	root	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	proliferation	proliferation	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	production	production	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	all	all	PDT	PDT	_	18	det:predet	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cytokines	cytokine	NNS	NNS	_	14	nmod	_	_
19	examined	examine	VBN	VBN	_	18	acl	_	_
20	.	.	.	.	_	9	punct	_	_

1	Addition	addition	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	rIL-2	ril-2	NN	NN	_	1	nmod	_	_
4	fully	fully	RB	RB	_	5	advmod	_	_
5	restored	restore	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	proliferative	proliferative	JJ	JJ	_	8	amod	_	_
8	response	response	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	partially	partially	RB	RB	_	11	advmod	_	_
11	restored	restore	VBD	VBD	_	5	conj	_	_
12	the	the	DT	DT	_	13	det	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IL-4	il-4	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IL-5	il-5	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	13	cc	_	_
21	that	that	DT	DT	_	13	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	other	other	JJ	JJ	_	24	amod	_	_
24	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	cells	cell	NNS	NNS	_	17	nmod	_	_
6	stimulated	stimulate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	14	case	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	myristate	myristate	NN	NN	_	10	compound	_	_
10	acetate	acetate	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMA	pma	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	/A23187	/a23187	NN	NN	_	6	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	PGE2	pge2	NN	NN	_	17	nsubj	_	_
17	enhanced	enhance	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	production	production	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-4	il-4	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-5	il-5	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	only	only	RB	RB	_	27	advmod	_	_
27	partially	partially	RB	RB	_	17	advmod	_	_
28	inhibited	inhibit	VBD	VBD	_	17	conj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	production	production	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	other	other	JJ	JJ	_	33	amod	_	_
33	cytokines	cytokine	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	Therefore	therefore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PGE2	pge2	NN	NN	_	4	nmod	_	_
7	vary	vary	VBP	VBP	_	0	root	_	_
8	depending	depend	VBG	VBG	_	11	case	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mode	mode	NN	NN	_	7	advcl	_	_
12	of	of	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	IL-4	il-4	NN	NN	_	23	nsubjpass	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-5	il-5	NN	NN	_	19	conj	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	regulated	regulate	VBN	VBN	_	7	conj	_	_
24	differently	differently	RB	RB	_	23	advmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	cytokines	cytokine	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	a	a	DT	DT	_	5	det	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	16	nmod	_	_
6	,	,	,	,	_	16	punct	_	_
7	only	only	RB	RB	_	14	advmod	_	_
8	the	the	DT	DT	_	14	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
10	B	b	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	p50/p50	p50/p50	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	homodimer	homodimer	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	complex	complex	NN	NN	_	16	nmod	_	_
20	formed	form	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	kappa	kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	unstimulated	unstimulated	JJ	JJ	_	29	amod	_	_
28	SP-B21	sp-b21	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	stimulated	stimulate	VBN	VBN	_	27	advcl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	anti-CD3	anti-cd3	JJ	JJ	_	7	amod	_	_
7	mAb	mab	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	PMA/A23187	pma/a23187	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	27	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	complex	complex	NN	NN	_	13	compound	_	_
13	formation	formation	NN	NN	_	27	nsubjpass	_	_
14	of	of	IN	IN	_	20	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	p50/p65	p50/p65	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	heterodimer	heterodimer	NN	NN	_	13	nmod	_	_
21	with	with	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	kappa	kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	13	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	induced	induce	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	PGE2	pge2	NN	NN	_	10	nsubj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	di-butyryl	di-butyryl	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	Bt2	bt2	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	cAMP	camp	NN	NN	_	3	conj	_	_
10	abolished	abolish	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	binding	binding	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	19	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
15	B	b	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	p50/p65	p50/p65	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	heterodimer	heterodimer	NN	NN	_	12	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	kappa	kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	12	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	cells	cell	NNS	NNS	_	24	nmod	_	_
27	stimulated	stimulate	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	30	case	_	_
29	anti-CD3	anti-cd3	JJ	JJ	_	30	amod	_	_
30	mAb	mab	NN	NN	_	27	nmod	_	_
31	but	but	CC	CC	_	30	cc	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	with	with	IN	IN	_	34	case	_	_
34	PMA/A23187	pma/a23187	NN	NN	_	30	conj	_	_
35	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	target	target	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	PGE2	pge2	NN	NN	_	9	compound	_	_
9	action	action	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	component	component	NN	NN	_	3	ccomp	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	signal	signal	NN	NN	_	17	compound	_	_
16	transduction	transduction	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	12	nmod	_	_
18	leading	lead	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	protein	protein	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	C	c	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	inhibition	inhibition	NN	NN	_	14	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	T	t	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	activation	activation	NN	NN	_	10	compound	_	_
10	signals	signal	NNS	NNS	_	4	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	PGE2	pge2	NN	NN	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	selective	selective	JJ	JJ	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	PGE2	pge2	NN	NN	_	2	nsubj	_	_
2	enhanced	enhance	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	complex	complex	NN	NN	_	5	compound	_	_
5	formation	formation	NN	NN	_	2	dobj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	NF-AT	nf-at	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	AP-1	ap-1	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	CLE0	cle0	NN	NN	_	7	conj	_	_
12	sequences	sequence	NNS	NNS	_	7	dep	_	_
13	when	when	WRB	WRB	_	17	advmod	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	activated	activate	VBN	VBN	_	2	advcl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	either	either	CC	CC	_	21	cc:preconj	_	_
20	anti-CD3	anti-cd3	JJ	JJ	_	21	amod	_	_
21	mAb	mab	NN	NN	_	17	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	PMA/A23187	pma/a23187	NN	NN	_	21	conj	_	_
24	stimulation	stimulation	NN	NN	_	21	dep	_	_
25	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	seems	seem	VBZ	VBZ	_	0	root	_	_
3	therefore	therefore	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	PGE2	pge2	NN	NN	_	12	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	elevating	elevate	VBG	VBG	_	12	advcl	_	_
9	cAMP	camp	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	,	,	,	,	_	12	punct	_	_
12	interferes	interfere	VBZ	VBZ	_	2	ccomp	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	pathway	pathway	NN	NN	_	12	nmod	_	_
17	for	for	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	but	but	CC	CC	_	19	cc	_	_
21	not	not	RB	RB	_	23	neg	_	_
22	for	for	IN	IN	_	23	case	_	_
23	NF-AT	nf-at	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	AP-1	ap-1	NN	NN	_	23	conj	_	_
26	or	or	CC	CC	_	23	cc	_	_
27	CLE0	cle0	NN	NN	_	23	conj	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	23	dep	_	_
30	.	.	.	.	_	2	punct	_	_

1	HLA-DR-	hla-dr-	JJ	JJ	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	CD33+	cd33+	JJ	JJ	_	1	appos	_	_
4	,	,	,	,	_	1	punct	_	_
5	CD56+	cd56+	JJ	JJ	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	CD16-	cd16-	JJ	JJ	_	1	appos	_	_
8	myeloid/natural	myeloid/natural	JJ	JJ	_	12	amod	_	_
9	killer	killer	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	acute	acute	JJ	JJ	_	12	amod	_	_
12	leukemia	leukemia	NN	NN	_	1	dep	_	_
13	:	:	:	:	_	1	punct	_	_
14	a	a	DT	DT	_	17	det	_	_
15	previously	previously	RB	RB	_	16	advmod	_	_
16	unrecognized	unrecognized	JJ	JJ	_	17	amod	_	_
17	form	form	NN	NN	_	1	dep	_	_
18	of	of	IN	IN	_	20	case	_	_
19	acute	acute	JJ	JJ	_	20	amod	_	_
20	leukemia	leukemia	NN	NN	_	17	nmod	_	_
21	potentially	potentially	RB	RB	_	22	advmod	_	_
22	misdiagnosed	misdiagnosed	JJ	JJ	_	17	amod	_	_
23	as	as	IN	IN	_	27	case	_	_
24	French-American-British	french-american-british	JJ	JJ	_	26	amod	_	_
25	acute	acute	JJ	JJ	_	26	amod	_	_
26	myeloid	myeloid	JJ	JJ	_	27	amod	_	_
27	leukemia-M3	leukemia-m3	NN	NN	_	22	nmod	_	_
28	-LSB-	-lsb-	-LRB-	-LRB-	_	29	punct	_	_
29	see	see	VB	VB	_	1	dep	_	_
30	comments	comment	NNS	NNS	_	29	dobj	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	29	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	characterized	characterize	VBN	VBN	_	3	conj	_	_
6	a	a	DT	DT	_	9	det	_	_
7	previously	previously	RB	RB	_	8	advmod	_	_
8	unrecognized	unrecognized	JJ	JJ	_	9	amod	_	_
9	form	form	NN	NN	_	3	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	acute	acute	JJ	JJ	_	12	amod	_	_
12	leukemia	leukemia	NN	NN	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	shares	share	VBZ	VBZ	_	9	acl:relcl	_	_
15	features	feature	NNS	NNS	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	myeloid	myeloid	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	natural	natural	JJ	JJ	_	21	amod	_	_
21	killer	killer	NN	NN	_	18	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NK	nk	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	cells	cell	NNS	NNS	_	18	dep	_	_
26	.	.	.	.	_	3	punct	_	_

1	From	from	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	consecutive	consecutive	JJ	JJ	_	4	amod	_	_
4	series	series	NN	NN	_	20	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	350	350	CD	CD	_	7	nummod	_	_
7	cases	case	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	adult	adult	JJ	JJ	_	14	amod	_	_
10	de	de	FW	FW	_	14	amod	_	_
11	novo	novo	FW	FW	_	10	dep	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	7	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	AML	aml	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	identified	identify	VBD	VBD	_	0	root	_	_
21	20	20	CD	CD	_	22	nummod	_	_
22	cases	case	NNS	NNS	_	20	dobj	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	6	6	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	with	with	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	unique	unique	JJ	JJ	_	30	amod	_	_
30	immunophenotype	immunophenotype	NN	NN	_	20	nmod	_	_
31	:	:	:	:	_	20	punct	_	_
32	CD33+	cd33+	JJ	JJ	_	20	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	CD56+	cd56+	JJ	JJ	_	32	appos	_	_
35	,	,	,	,	_	32	punct	_	_
36	CD11a+	cd11a+	JJ	JJ	_	32	appos	_	_
37	,	,	,	,	_	32	punct	_	_
38	CD13lo	cd13lo	JJ	JJ	_	32	appos	_	_
39	,	,	,	,	_	32	punct	_	_
40	CD15lo	cd15lo	JJ	JJ	_	32	appos	_	_
41	,	,	,	,	_	32	punct	_	_
42	CD34+/-	cd34+/-	JJ	JJ	_	32	appos	_	_
43	,	,	,	,	_	32	punct	_	_
44	HLA-DR-	hla-dr-	JJ	JJ	_	32	appos	_	_
45	,	,	,	,	_	32	punct	_	_
46	CD16-	cd16-	JJ	JJ	_	32	appos	_	_
47	.	.	.	.	_	20	punct	_	_

1	Multicolor	multicolor	JJ	JJ	_	4	amod	_	_
2	flow	flow	NN	NN	_	4	compound	_	_
3	cytometric	cytometric	JJ	JJ	_	4	amod	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	confirmed	confirm	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	coexpression	coexpression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	15	case	_	_
9	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	CD33	cd33	NN	NN	_	15	compound	_	_
12	,	,	,	,	_	15	punct	_	_
13	CD13	cd13	NN	NN	_	15	dep	_	_
14	,	,	,	,	_	15	punct	_	_
15	CD15	cd15	NN	NN	_	7	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	NK	nk	NN	NN	_	21	compound	_	_
19	cell-associated	cell-associated	JJ	JJ	_	21	amod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CD56	cd56	NN	NN	_	15	conj	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	antigens	antigen	NNS	NNS	_	15	dep	_	_
24	in	in	IN	IN	_	26	case	_	_
25	each	each	DT	DT	_	26	det	_	_
26	case	case	NN	NN	_	5	nmod	_	_
27	,	,	,	,	_	5	punct	_	_
28	whereas	whereas	IN	IN	_	38	mark	_	_
29	reverse	reverse	NN	NN	_	33	compound	_	_
30	transcription	transcription	NN	NN	_	33	compound	_	_
31	polymerase	polymerase	NN	NN	_	33	compound	_	_
32	chain	chain	NN	NN	_	33	compound	_	_
33	reaction	reaction	NN	NN	_	37	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	RT-PCR	rt-pcr	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	assays	assay	NNS	NNS	_	38	nsubj	_	_
38	confirmed	confirm	VBD	VBD	_	5	advcl	_	_
39	the	the	DT	DT	_	40	det	_	_
40	identity	identity	NN	NN	_	38	dobj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	CD56	cd56	NN	NN	_	40	nmod	_	_
43	(	(	-LRB-	-LRB-	_	47	punct	_	_
44	neural	neural	JJ	JJ	_	47	amod	_	_
45	cell	cell	NN	NN	_	47	compound	_	_
46	adhesion	adhesion	NN	NN	_	47	compound	_	_
47	molecule	molecule	NN	NN	_	42	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	in	in	IN	IN	_	51	case	_	_
50	leukemic	leukemic	JJ	JJ	_	51	amod	_	_
51	blasts	blast	NNS	NNS	_	38	nmod	_	_
52	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	cases	case	NNS	NNS	_	4	nsubj	_	_
4	expressed	express	VBD	VBD	_	9	advcl	_	_
5	CD4	cd4	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	9	punct	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	case	case	NN	NN	_	9	nsubj	_	_
9	expressed	express	VBD	VBD	_	0	root	_	_
10	CD2	cd2	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	CD3	cd3	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	CD8	cd8	NN	NN	_	10	conj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	no	no	DT	DT	_	18	neg	_	_
18	case	case	NN	NN	_	19	nsubj	_	_
19	showed	show	VBD	VBD	_	9	conj	_	_
20	clonal	clonal	JJ	JJ	_	21	amod	_	_
21	rearrangement	rearrangement	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	genes	gene	NNS	NNS	_	21	nmod	_	_
24	encoding	encode	VBG	VBG	_	23	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	T-cell	t-cell	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	24	dobj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TCR	tcr	NN	NN	_	27	appos	_	_
30	beta	beta	NN	NN	_	29	dep	_	_
31	,	,	,	,	_	29	punct	_	_
32	gamma	gamma	NN	NN	_	29	appos	_	_
33	,	,	,	,	_	29	punct	_	_
34	delta	delta	NN	NN	_	29	appos	_	_
35	)	)	-RRB-	-RRB-	_	29	punct	_	_
36	.	.	.	.	_	9	punct	_	_

1	Leukemic	leukemic	JJ	JJ	_	2	amod	_	_
2	blasts	blast	NNS	NNS	_	8	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	majority	majority	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cases	case	NNS	NNS	_	5	nmod	_	_
8	shared	share	VBD	VBD	_	0	root	_	_
9	unique	unique	JJ	JJ	_	11	amod	_	_
10	morphologic	morphologic	JJ	JJ	_	9	dep	_	_
11	features	feature	NNS	NNS	_	8	dobj	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	deeply	deeply	RB	RB	_	15	advmod	_	_
14	invaginated	invaginated	JJ	JJ	_	15	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	membranes	membrane	NNS	NNS	_	11	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	scant	scant	JJ	JJ	_	19	amod	_	_
19	cytoplasm	cytoplasm	NN	NN	_	16	conj	_	_
20	with	with	IN	IN	_	23	case	_	_
21	fine	fine	JJ	JJ	_	23	amod	_	_
22	azurophilic	azurophilic	JJ	JJ	_	23	amod	_	_
23	granularity	granularity	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	16	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	finely	finely	RB	RB	_	27	advmod	_	_
27	granular	granular	JJ	JJ	_	30	amod	_	_
28	Sudan	sudan	NN	NN	_	30	compound	_	_
29	black	black	JJ	JJ	_	30	amod	_	_
30	B	b	NN	NN	_	16	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	myeloperoxidase	myeloperoxidase	NN	NN	_	30	conj	_	_
33	cytochemical	cytochemical	JJ	JJ	_	34	amod	_	_
34	reactivity	reactivity	NN	NN	_	30	dep	_	_
35	)	)	-RRB-	-RRB-	_	16	punct	_	_
36	that	that	WDT	WDT	_	39	nsubj	_	_
37	were	be	VBD	VBD	_	39	cop	_	_
38	remarkably	remarkably	RB	RB	_	39	advmod	_	_
39	similar	similar	JJ	JJ	_	8	dep	_	_
40	to	to	TO	TO	_	41	case	_	_
41	those	those	DT	DT	_	39	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	acute	acute	JJ	JJ	_	45	amod	_	_
44	promyelocytic	promyelocytic	JJ	JJ	_	45	amod	_	_
45	leukemia	leukemia	NN	NN	_	41	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	APL	apl	NN	NN	_	45	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	;	;	:	:	_	8	punct	_	_
50	particularly	particularly	RB	RB	_	53	advmod	_	_
51	the	the	DT	DT	_	53	det	_	_
52	microgranular	microgranular	JJ	JJ	_	53	amod	_	_
53	variant	variant	NN	NN	_	8	dep	_	_
54	(	(	-LRB-	-LRB-	_	56	punct	_	_
55	FAB	fab	NN	NN	_	56	compound	_	_
56	AML-M3v	aml-m3v	NN	NN	_	53	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	all	all	DT	DT	_	5	det	_	_
4	20	20	CD	CD	_	5	nummod	_	_
5	cases	case	NNS	NNS	_	6	nsubj	_	_
6	lacked	lack	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	t(15;17)	t(15;17)	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	17	17	CD	CD	_	11	nummod	_	_
11	cases	case	NNS	NNS	_	13	nsubj	_	_
12	tested	test	VBN	VBN	_	11	acl	_	_
13	lacked	lack	VBD	VBD	_	6	conj	_	_
14	the	the	DT	DT	_	24	det	_	_
15	promyelocytic/retinoic	promyelocytic/retinoic	JJ	JJ	_	24	amod	_	_
16	acid	acid	NN	NN	_	24	compound	_	_
17	receptor	receptor	NN	NN	_	24	compound	_	_
18	alpha	alpha	NN	NN	_	24	compound	_	_
19	(	(	-LRB-	-LRB-	_	24	punct	_	_
20	RAR	rar	NN	NN	_	24	compound	_	_
21	alpha	alpha	NN	NN	_	24	compound	_	_
22	)	)	-RRB-	-RRB-	_	24	punct	_	_
23	fusion	fusion	NN	NN	_	24	compound	_	_
24	transcript	transcript	NN	NN	_	13	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	RT-PCR	rt-pcr	NN	NN	_	27	compound	_	_
27	assays	assay	NNS	NNS	_	13	nmod	_	_
28	;	;	:	:	_	6	punct	_	_
29	12	12	CD	CD	_	30	nummod	_	_
30	cases	case	NNS	NNS	_	31	nsubj	_	_
31	had	have	VBD	VBD	_	6	parataxis	_	_
32	46,XX	46,xx	NN	NN	_	31	dobj	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	46,XY	46,xy	NN	NN	_	32	conj	_	_
35	karyotypes	karyotype	NNS	NNS	_	32	dep	_	_
36	,	,	,	,	_	31	punct	_	_
37	whereas	whereas	IN	IN	_	40	mark	_	_
38	2	2	CD	CD	_	39	nummod	_	_
39	cases	case	NNS	NNS	_	40	nsubj	_	_
40	had	have	VBD	VBD	_	31	advcl	_	_
41	abnormalities	abnormality	NNS	NNS	_	40	dobj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	chromosome	chromosome	NN	NN	_	44	compound	_	_
44	17q	17q	NN	NN	_	41	nmod	_	_
45	:	:	:	:	_	6	punct	_	_
46	1	1	CD	CD	_	6	dep	_	_
47	with	with	IN	IN	_	48	case	_	_
48	del(17)(q25)	del(17)(q25)	NN	NN	_	46	nmod	_	_
49	and	and	CC	CC	_	46	cc	_	_
50	the	the	DT	DT	_	51	det	_	_
51	other	other	JJ	JJ	_	46	conj	_	_
52	with	with	IN	IN	_	53	case	_	_
53	t(11;17)(q23;q21)	t(11;17)(q23;q21)	NN	NN	_	51	nmod	_	_
54	and	and	CC	CC	_	53	cc	_	_
55	the	the	DT	DT	_	62	det	_	_
56	promyelocytic	promyelocytic	JJ	JJ	_	62	amod	_	_
57	leukemia	leukemia	NN	NN	_	62	compound	_	_
58	zinc	zinc	NN	NN	_	62	compound	_	_
59	finger/RAR	finger/rar	NN	NN	_	62	compound	_	_
60	alpha	alpha	NN	NN	_	62	compound	_	_
61	fusion	fusion	NN	NN	_	62	compound	_	_
62	transcript	transcript	NN	NN	_	53	conj	_	_
63	.	.	.	.	_	6	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	cases	case	NNS	NNS	_	14	nsubj	_	_
3	tested	test	VBN	VBN	_	2	acl	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	6/20	6/20	CD	CD	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	2	punct	_	_
8	including	include	VBG	VBG	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	case	case	NN	NN	_	2	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	t(11;17)	t(11;17)	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	failed	fail	VBD	VBD	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	differentiate	differentiate	VB	VB	_	14	xcomp	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	16	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	all-trans	all-trans	JJ	JJ	_	24	amod	_	_
23	retinoic	retinoic	JJ	JJ	_	24	amod	_	_
24	acid	acid	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	ATRA	atra	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	14	punct	_	_
29	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
30	that	that	IN	IN	_	34	mark	_	_
31	these	these	DT	DT	_	32	det	_	_
32	cases	case	NNS	NNS	_	34	nsubj	_	_
33	may	may	MD	MD	_	34	aux	_	_
34	account	account	VB	VB	_	29	ccomp	_	_
35	for	for	IN	IN	_	37	case	_	_
36	some	some	DT	DT	_	37	det	_	_
37	APLs	apl	NNS	NNS	_	34	nmod	_	_
38	that	that	WDT	WDT	_	41	nsubj	_	_
39	have	have	VBP	VBP	_	41	aux	_	_
40	not	not	RB	RB	_	41	neg	_	_
41	shown	show	VBN	VBN	_	37	acl:relcl	_	_
42	a	a	DT	DT	_	44	det	_	_
43	clinical	clinical	JJ	JJ	_	44	amod	_	_
44	response	response	NN	NN	_	41	dobj	_	_
45	to	to	TO	TO	_	46	case	_	_
46	ATRA	atra	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	14	punct	_	_

1	Four	four	CD	CD	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	6	6	CD	CD	_	4	nummod	_	_
4	cases	case	NNS	NNS	_	1	nmod	_	_
5	tested	test	VBN	VBN	_	4	acl	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	functional	functional	JJ	JJ	_	10	amod	_	_
8	NK	nk	NN	NN	_	10	compound	_	_
9	cell-mediated	cell-mediated	JJ	JJ	_	10	amod	_	_
10	cytotoxicity	cytotoxicity	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
13	a	a	DT	DT	_	14	det	_	_
14	relationship	relationship	NN	NN	_	12	dobj	_	_
15	between	between	IN	IN	_	18	case	_	_
16	these	these	DT	DT	_	18	det	_	_
17	unique	unique	JJ	JJ	_	18	amod	_	_
18	CD33+	cd33+	JJ	JJ	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	CD56+	cd56+	JJ	JJ	_	18	appos	_	_
21	,	,	,	,	_	18	punct	_	_
22	CD16-	cd16-	JJ	JJ	_	18	appos	_	_
23	acute	acute	JJ	JJ	_	24	amod	_	_
24	leukemias	leukemia	NNS	NNS	_	18	dep	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	normal	normal	JJ	JJ	_	32	amod	_	_
27	CD56+	cd56+	JJ	JJ	_	32	amod	_	_
28	,	,	,	,	_	32	punct	_	_
29	CD16-	cd16-	JJ	JJ	_	32	amod	_	_
30	NK	nk	NN	NN	_	32	compound	_	_
31	precursor	precursor	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	18	conj	_	_
33	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	3	det	_	_
3	combination	combination	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	panning	panning	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	multiparameter	multiparameter	NN	NN	_	10	compound	_	_
8	flow	flow	NN	NN	_	10	compound	_	_
9	cytometric	cytometric	JJ	JJ	_	10	amod	_	_
10	sorting	sorting	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	1	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	identified	identify	VBD	VBD	_	1	parataxis	_	_
14	a	a	DT	DT	_	16	det	_	_
15	normal	normal	JJ	JJ	_	16	amod	_	_
16	CD56+	cd56+	JJ	JJ	_	13	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	CD33+	cd33+	JJ	JJ	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	CD16-	cd16-	JJ	JJ	_	16	appos	_	_
21	counterpart	counterpart	NN	NN	_	22	compound	_	_
22	cell	cell	NN	NN	_	16	dep	_	_
23	at	at	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	frequency	frequency	NN	NN	_	13	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	1	1	CD	CD	_	31	compound	_	_
28	%	%	NN	NN	_	31	dep	_	_
29	to	to	TO	TO	_	31	dep	_	_
30	2	2	CD	CD	_	31	compound	_	_
31	%	%	NN	NN	_	25	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	peripheral	peripheral	JJ	JJ	_	35	amod	_	_
35	blood	blood	NN	NN	_	13	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	healthy	healthy	JJ	JJ	_	38	amod	_	_
38	individuals	individual	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	1	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	form	form	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	acute	acute	JJ	JJ	_	9	amod	_	_
9	leukemia	leukemia	NN	NN	_	6	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	arise	arise	VB	VB	_	3	ccomp	_	_
12	from	from	IN	IN	_	13	case	_	_
13	transformation	transformation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	precursor	precursor	NN	NN	_	17	compound	_	_
17	cell	cell	NN	NN	_	13	nmod	_	_
18	common	common	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	myeloid	myeloid	JJ	JJ	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NK	nk	NN	NN	_	22	conj	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lineages	lineage	NNS	NNS	_	22	dep	_	_
27	;	;	:	:	_	3	punct	_	_
28	thus	thus	RB	RB	_	30	advmod	_	_
29	we	we	PRP	PRP	_	30	nsubj	_	_
30	propose	propose	VBP	VBP	_	3	parataxis	_	_
31	the	the	DT	DT	_	35	det	_	_
32	designation	designation	NN	NN	_	35	compound	_	_
33	myeloid/NK	myeloid/nk	JJ	JJ	_	35	amod	_	_
34	acute	acute	JJ	JJ	_	35	amod	_	_
35	leukemia	leukemia	NN	NN	_	30	dobj	_	_
36	.	.	.	.	_	3	punct	_	_

1	Recognition	recognition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	this	this	DT	DT	_	6	det	_	_
4	new	new	JJ	JJ	_	6	amod	_	_
5	leukemic	leukemic	JJ	JJ	_	6	amod	_	_
6	entity	entity	NN	NN	_	1	nmod	_	_
7	will	will	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	cop	_	_
9	important	important	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	distinguishing	distinguish	VBG	VBG	_	9	advcl	_	_
12	these	these	DT	DT	_	14	det	_	_
13	ATRA-nonresponsive	atra-nonresponsive	JJ	JJ	_	14	amod	_	_
14	cases	case	NNS	NNS	_	11	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	ATRA-responsive	atra-responsive	JJ	JJ	_	17	amod	_	_
17	true	true	JJ	JJ	_	18	amod	_	_
18	APL	apl	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Description	description	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	implications	implication	NNS	NNS	_	1	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	mutation	mutation	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	sex-determining	sex-determining	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	SRY	sry	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	sex-determining	sex-determining	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	SRY	sry	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	screened	screen	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	alteration	alteration	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	XY	xy	NN	NN	_	13	nmod:npmod	_	_
13	sex-reversed	sex-reversed	JJ	JJ	_	14	amod	_	_
14	female	female	NN	NN	_	9	nmod	_	_
15	by	by	IN	IN	_	22	case	_	_
16	single-strand	single-strand	JJ	JJ	_	18	amod	_	_
17	conformation	conformation	NN	NN	_	18	compound	_	_
18	polymorphism	polymorphism	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	SSCP	sscp	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	technique	technique	NN	NN	_	6	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	A-to-G	a-to-g	JJ	JJ	_	3	amod	_	_
3	transition	transition	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	leads	lead	VBZ	VBZ	_	5	ccomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	exchange	exchange	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	tyrosine	tyrosine	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	cysteine	cysteine	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	SRY	sry	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	affected	affect	VBN	VBN	_	4	amod	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	residue	residue	NN	NN	_	18	nsubjpass	_	_
5	located	located	JJ	JJ	_	4	amod	_	_
6	at	at	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	C	c	NN	NN	_	9	compound	_	_
9	terminus	terminus	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	9	nmod	_	_
15	is	be	VBZ	VBZ	_	18	auxpass	_	_
16	evolutionarily	evolutionarily	RB	RB	_	17	advmod	_	_
17	strongly	strongly	RB	RB	_	18	advmod	_	_
18	conserved	conserve	VBN	VBN	_	0	root	_	_
19	among	among	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	members	member	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	HMG	hmg	NN	NN	_	26	dep	_	_
25	box	box	NN	NN	_	26	dep	_	_
26	containing	contain	VBG	VBG	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	Using	use	VBG	VBG	_	12	dep	_	_
2	gel	gel	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	1	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	peptide	peptide	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	4	conj	_	_
8	such	such	PDT	PDT	_	10	det:predet	_	_
9	a	a	DT	DT	_	10	det	_	_
10	mutation	mutation	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	abolish	abolish	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	20	det	_	_
16	SRY	sry	NN	NN	_	20	compound	_	_
17	protein	protein	NN	NN	_	20	compound	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	ability	ability	NN	NN	_	14	dobj	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	this	this	DT	DT	_	7	det	_	_
5	particular	particular	JJ	JJ	_	7	amod	_	_
6	amino	amino	NN	NN	_	7	compound	_	_
7	acid	acid	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	specificity	specificity	NN	NN	_	2	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	discussed	discuss	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	0	root	_	_
2	B-dependent	b-dependent	JJ	JJ	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	-independent	-independent	JJ	JJ	_	1	conj	_	_
5	pathways	pathway	NNS	NNS	_	1	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	15	case	_	_
10	a	a	DT	DT	_	15	det	_	_
11	chronically	chronically	RB	RB	_	15	advmod	_	_
12	infected	infected	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	J	j	NN	NN	_	4	compound	_	_
2	delta	delta	NN	NN	_	4	compound	_	_
3	K	k	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	isolated	isolate	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	13	case	_	_
8	a	a	DT	DT	_	13	det	_	_
9	chronically	chronically	RB	RB	_	13	advmod	_	_
10	infected	infected	JJ	JJ	_	13	amod	_	_
11	survivor	survivor	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	following	follow	VBG	VBG	_	16	case	_	_
16	infection	infection	NN	NN	_	6	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	Jurkat	jurkat	NN	NN	_	21	compound	_	_
19	CD4+	cd4+	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	dl-NF	dl-nf	NN	NN	_	16	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	a	a	DT	DT	_	27	det	_	_
26	mutated	mutate	VBN	VBN	_	27	amod	_	_
27	strain	strain	NN	NN	_	23	appos	_	_
28	of	of	IN	IN	_	32	case	_	_
29	human	human	JJ	JJ	_	32	amod	_	_
30	immunodeficiency	immunodeficiency	NN	NN	_	32	compound	_	_
31	virus	virus	NN	NN	_	32	compound	_	_
32	type	type	NN	NN	_	27	nmod	_	_
33	1	1	CD	CD	_	32	nummod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	HIV-1	hiv-1	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	containing	contain	VBG	VBG	_	32	acl	_	_
38	a	a	DT	DT	_	39	det	_	_
39	deletion	deletion	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	50	case	_	_
41	the	the	DT	DT	_	50	det	_	_
42	long	long	JJ	JJ	_	44	amod	_	_
43	terminal	terminal	JJ	JJ	_	44	amod	_	_
44	repeat	repeat	NN	NN	_	50	compound	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	LTR	ltr	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	NF-kappa	nf-kappa	NN	NN	_	50	compound	_	_
49	B	b	NN	NN	_	50	compound	_	_
50	sites	site	NNS	NNS	_	39	nmod	_	_
51	.	.	.	.	_	6	punct	_	_

1	J	j	NN	NN	_	4	compound	_	_
2	delta	delta	NN	NN	_	4	compound	_	_
3	K	k	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	very	very	RB	RB	_	7	advmod	_	_
7	low	low	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	constitutive	constitutive	JJ	JJ	_	12	amod	_	_
11	HIV	hiv	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	activated	activate	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	9	case	_	_
6	J	j	NN	NN	_	9	compound	_	_
7	delta	delta	NN	NN	_	9	compound	_	_
8	K	k	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	treatment	treatment	NN	NN	_	4	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	phorbol	phorbol	NN	NN	_	15	compound	_	_
14	myristate	myristate	NN	NN	_	15	compound	_	_
15	acetate	acetate	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	sodium	sodium	NN	NN	_	21	compound	_	_
21	butyrate	butyrate	NN	NN	_	15	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NaB	nab	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	15	punct	_	_
26	or	or	CC	CC	_	15	cc	_	_
27	hexamethylene	hexamethylene	NN	NN	_	28	compound	_	_
28	bisacetamide	bisacetamide	NN	NN	_	15	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HMBA	hmba	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	15	punct	_	_
33	but	but	CC	CC	_	34	cc	_	_
34	not	not	RB	RB	_	15	cc	_	_
35	tumor	tumor	NN	NN	_	38	compound	_	_
36	necrosis	necrosis	NN	NN	_	38	compound	_	_
37	factor	factor	NN	NN	_	38	compound	_	_
38	alpha	alpha	NN	NN	_	15	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	TNF-alpha	tnf-alpha	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	4	punct	_	_
43	confirming	confirm	VBG	VBG	_	4	advcl	_	_
44	the	the	DT	DT	_	45	det	_	_
45	role	role	NN	NN	_	43	dobj	_	_
46	of	of	IN	IN	_	48	case	_	_
47	NF-kappa	nf-kappa	NN	NN	_	48	compound	_	_
48	B	b	NN	NN	_	45	nmod	_	_
49	in	in	IN	IN	_	50	mark	_	_
50	mediating	mediate	VBG	VBG	_	43	advcl	_	_
51	TNF-alpha	tnf-alpha	NN	NN	_	52	compound	_	_
52	induction	induction	NN	NN	_	50	dobj	_	_
53	of	of	IN	IN	_	55	case	_	_
54	HIV	hiv	NN	NN	_	55	compound	_	_
55	transcription	transcription	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	strong	strong	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HIV	hiv	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	NaB	nab	NN	NN	_	3	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	HMBA	hmba	NN	NN	_	8	conj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	J	j	NN	NN	_	15	compound	_	_
13	delta	delta	NN	NN	_	15	compound	_	_
14	K	k	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	clearly	clearly	RB	RB	_	17	advmod	_	_
17	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	existence	existence	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B-independent	b-independent	JJ	JJ	_	23	amod	_	_
23	mechanisms	mechanism	NNS	NNS	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	chronically	chronically	RB	RB	_	30	advmod	_	_
29	infected	infected	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	J	j	NN	NN	_	4	compound	_	_
2	delta	delta	NN	NN	_	4	compound	_	_
3	K	k	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	provide	provide	VB	VB	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	useful	useful	JJ	JJ	_	9	amod	_	_
9	model	model	NN	NN	_	6	dobj	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	characterizing	characterize	VBG	VBG	_	9	acl	_	_
12	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
13	B-independent	b-independent	JJ	JJ	_	15	amod	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	11	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	LTR	ltr	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	down-regulates	down-regulate	VBZ	VBZ	_	0	root	_	_
3	IL-2-	il-2-	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	IL-3-	il-3-	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	GM-CSF-induced	gm-csf-induced	JJ	JJ	_	3	conj	_	_
9	cytokine	cytokine	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	3	dep	_	_
12	in	in	IN	IN	_	15	case	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	IL-4	il-4	NN	NN	_	21	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	product	product	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	T-helper	t-helper	NN	NN	_	4	nmod	_	_
8	0	0	CD	CD	_	7	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Th0	th0	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	2	2	CD	CD	_	7	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Th2	th2	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	subset	subset	NN	NN	_	7	dep	_	_
18	,	,	,	,	_	1	punct	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	originally	originally	RB	RB	_	21	advmod	_	_
21	described	describe	VBN	VBN	_	0	root	_	_
22	as	as	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	B-cell	b-cell	NN	NN	_	26	compound	_	_
25	stimulatory	stimulatory	JJ	JJ	_	26	amod	_	_
26	factor	factor	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	has	have	VBZ	VBZ	_	31	aux	_	_
29	subsequently	subsequently	RB	RB	_	31	advmod	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	found	find	VBN	VBN	_	21	conj	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	suppress	suppress	VB	VB	_	31	ccomp	_	_
34	IL-1	il-1	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	33	dobj	_	_
36	,	,	,	,	_	35	punct	_	_
37	IL-1	il-1	NN	NN	_	38	compound	_	_
38	beta	beta	NN	NN	_	35	conj	_	_
39	,	,	,	,	_	35	punct	_	_
40	IL-6	il-6	NN	NN	_	35	conj	_	_
41	,	,	,	,	_	35	punct	_	_
42	IL-8	il-8	NN	NN	_	35	conj	_	_
43	,	,	,	,	_	35	punct	_	_
44	and	and	CC	CC	_	35	cc	_	_
45	TNF-alpha	tnf-alpha	NN	NN	_	35	conj	_	_
46	gene	gene	NN	NN	_	47	compound	_	_
47	expression	expression	NN	NN	_	35	dep	_	_
48	in	in	IN	IN	_	49	case	_	_
49	monocytes	monocyte	NNS	NNS	_	35	nmod	_	_
50	stimulated	stimulate	VBN	VBN	_	49	acl	_	_
51	with	with	IN	IN	_	52	case	_	_
52	LPS	lps	NN	NN	_	50	nmod	_	_
53	,	,	,	,	_	33	punct	_	_
54	and	and	CC	CC	_	33	cc	_	_
55	to	to	TO	TO	_	56	mark	_	_
56	upregulate	upregulate	VB	VB	_	33	conj	_	_
57	IL-1	il-1	NN	NN	_	64	compound	_	_
58	receptor	receptor	NN	NN	_	64	compound	_	_
59	antagonist	antagonist	NN	NN	_	64	compound	_	_
60	(	(	-LRB-	-LRB-	_	64	punct	_	_
61	IL1-RA	il1-ra	NN	NN	_	64	compound	_	_
62	)	)	-RRB-	-RRB-	_	64	punct	_	_
63	gene	gene	NN	NN	_	64	compound	_	_
64	expression	expression	NN	NN	_	56	dobj	_	_
65	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IL-4	il-4	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
18	evoked	evoke	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	23	case	_	_
20	other	other	JJ	JJ	_	23	amod	_	_
21	T-helper	t-helper	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
24	:	:	:	:	_	5	punct	_	_
25	IL-2	il-2	NN	NN	_	5	dep	_	_
26	,	,	,	,	_	25	punct	_	_
27	IL-3	il-3	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	GM-CSF	gm-csf	NN	NN	_	25	conj	_	_
31	.	.	.	.	_	5	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	down-regulated	down-regulate	VBD	VBD	_	0	root	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	accumulation	accumulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	proinflammatory	proinflammatory	JJ	JJ	_	8	amod	_	_
8	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
9	IL-1	il-1	NN	NN	_	10	compound	_	_
10	beta	beta	NN	NN	_	8	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	IL-8	il-8	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	10	conj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
18	stimulated	stimulate	VBN	VBN	_	8	acl	_	_
19	with	with	IN	IN	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	IL-3	il-3	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	GM-CSF	gm-csf	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	2	punct	_	_

1	IL-4	il-4	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	suppressed	suppress	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	IL-2-induced	il-2-induced	JJ	JJ	_	8	amod	_	_
6	IL-6	il-6	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	3	dobj	_	_
9	.	.	.	.	_	3	punct	_	_

1	Temporal	temporal	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	IL-4	il-4	NN	NN	_	7	compound	_	_
6	down-regulatory	down-regulatory	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	2	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	IL-2-	il-2-	NN	NN	_	2	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	IL-3-	il-3-	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	GM-CSF-induced	gm-csf-induced	JJ	JJ	_	10	conj	_	_
16	proinflammatory	proinflammatory	JJ	JJ	_	19	amod	_	_
17	cytokine	cytokine	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	10	dep	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
22	provided	provide	VBD	VBD	_	0	root	_	_
23	evidence	evidence	NN	NN	_	22	dobj	_	_
24	that	that	IN	IN	_	25	mark	_	_
25	IL-4	il-4	NN	NN	_	23	ccomp	_	_
26	acts	act	VBZ	VBZ	_	25	dep	_	_
27	predominantly	predominantly	RB	RB	_	26	advmod	_	_
28	on	on	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	post-transcriptional	post-transcriptional	JJ	JJ	_	31	amod	_	_
31	level	level	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	supported	support	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	observation	observation	NN	NN	_	3	nmod	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	down-regulatory	down-regulatory	JJ	JJ	_	10	amod	_	_
10	capacity	capacity	NN	NN	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-4	il-4	NN	NN	_	10	nmod	_	_
13	appeared	appear	VBD	VBD	_	6	ccomp	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	dependent	dependent	JJ	JJ	_	13	xcomp	_	_
17	on	on	IN	IN	_	21	case	_	_
18	de	de	FW	FW	_	21	amod	_	_
19	novo	novo	FW	FW	_	18	dep	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	synthesis	synthesis	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	IL-4	il-4	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	exert	exert	VB	VB	_	0	root	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	influence	influence	NN	NN	_	4	dobj	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-1-RA	il-1-ra	NN	NN	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	various	various	JJ	JJ	_	16	amod	_	_
16	CSFs	csf	NNS	NNS	_	13	conj	_	_
17	by	by	IN	IN	_	18	case	_	_
18	IL-2	il-2	NN	NN	_	11	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	IL-3	il-3	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	GM-CSF	gm-csf	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Long-term	long-term	JJ	JJ	_	4	amod	_	_
2	inositol	inositol	NN	NN	_	4	compound	_	_
3	phosphate	phosphate	NN	NN	_	4	compound	_	_
4	release	release	NN	NN	_	12	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	correlates	correlate	VBZ	VBZ	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	secretion	secretion	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-AT	nf-at	NN	NN	_	18	compound	_	_
18	induction	induction	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	24	case	_	_
20	anti-CD3-activated	anti-cd3-activated	JJ	JJ	_	24	amod	_	_
21	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cascade	cascade	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	events	event	NNS	NNS	_	2	nmod	_	_
5	within	within	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	first	first	JJ	JJ	_	8	amod	_	_
8	few	few	JJ	JJ	_	9	amod	_	_
9	minutes	minute	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	stimulation	stimulation	NN	NN	_	9	nmod	_	_
14	has	have	VBZ	VBZ	_	17	aux	_	_
15	been	be	VBN	VBN	_	17	auxpass	_	_
16	well	well	RB	RB	_	17	advmod	_	_
17	characterized	characterize	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	many	many	JJ	JJ	_	4	amod	_	_
3	second	second	JJ	JJ	_	4	amod	_	_
4	messengers	messenger	NNS	NNS	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	34	advcl	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	necessary	necessary	JJ	JJ	_	7	xcomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
13	for	for	IN	IN	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	number	number	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	model	model	NN	NN	_	22	compound	_	_
22	systems	system	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	34	punct	_	_
24	the	the	DT	DT	_	26	det	_	_
25	rate-limiting	rate-limiting	JJ	JJ	_	26	amod	_	_
26	step	step	NN	NN	_	34	nsubjpass	_	_
27	in	in	IN	IN	_	30	case	_	_
28	peripheral	peripheral	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	has	have	VBZ	VBZ	_	34	aux	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	been	be	VBN	VBN	_	34	auxpass	_	_
34	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	model	model	VB	VB	_	0	root	_	_
3	effective	effective	JJ	JJ	_	2	dobj	_	_
4	versus	versus	CC	CC	_	3	cc	_	_
5	ineffective	ineffective	JJ	JJ	_	3	conj	_	_
6	CD3-mediated	cd3-mediated	JJ	JJ	_	7	amod	_	_
7	stimulation	stimulation	NN	NN	_	3	dep	_	_
8	in	in	IN	IN	_	11	case	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	used	use	VBD	VBD	_	2	parataxis	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	anti-CD3	anti-cd3	JJ	JJ	_	17	amod	_	_
17	mAbs	mab	NNS	NNS	_	14	dobj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	differ	differ	VBP	VBP	_	14	dep	_	_
20	in	in	IN	IN	_	22	case	_	_
21	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
22	ability	ability	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	stimulate	stimulate	VB	VB	_	22	acl	_	_
25	purified	purify	VBN	VBN	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	dobj	_	_
28	:	:	:	:	_	2	punct	_	_
29	OKT3	okt3	NN	NN	_	2	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	causes	cause	VBZ	VBZ	_	29	acl:relcl	_	_
33	early	early	JJ	JJ	_	36	amod	_	_
34	second	second	JJ	JJ	_	36	amod	_	_
35	messenger	messenger	NN	NN	_	36	compound	_	_
36	generation	generation	NN	NN	_	32	dobj	_	_
37	but	but	CC	CC	_	32	cc	_	_
38	is	be	VBZ	VBZ	_	39	cop	_	_
39	unable	unable	JJ	JJ	_	32	conj	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	activate	activate	VB	VB	_	39	xcomp	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	41	dobj	_	_
44	without	without	IN	IN	_	47	case	_	_
45	a	a	DT	DT	_	47	det	_	_
46	second	second	JJ	JJ	_	47	amod	_	_
47	signal	signal	NN	NN	_	41	nmod	_	_
48	,	,	,	,	_	29	punct	_	_
49	and	and	CC	CC	_	29	cc	_	_
50	64.1	64.1	CD	CD	_	29	conj	_	_
51	,	,	,	,	_	50	punct	_	_
52	which	which	WDT	WDT	_	53	nsubj	_	_
53	stimulates	stimulate	VBZ	VBZ	_	50	acl:relcl	_	_
54	T	t	NN	NN	_	56	compound	_	_
55	cell	cell	NN	NN	_	56	compound	_	_
56	proliferation	proliferation	NN	NN	_	53	dobj	_	_
57	on	on	IN	IN	_	59	case	_	_
58	its	its	PRP$	PRP$	_	59	nmod:poss	_	_
59	own	own	JJ	JJ	_	53	nmod	_	_
60	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	similar	similar	JJ	JJ	_	2	ccomp	_	_
9	for	for	IN	IN	_	11	case	_	_
10	both	both	DT	DT	_	11	det	_	_
11	mAbs	mab	NNS	NNS	_	8	nmod	_	_
12	over	over	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	period	period	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	hours	hour	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	inositol	inositol	NN	NN	_	6	compound	_	_
5	phosphate	phosphate	NN	NN	_	6	compound	_	_
6	response	response	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	stronger	stronger	JJR	JJR	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	64.1	64.1	CD	CD	_	8	nmod	_	_
11	than	than	IN	IN	_	13	case	_	_
12	for	for	IN	IN	_	13	case	_	_
13	OKT3	okt3	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	tie	tie	VB	VB	_	0	root	_	_
3	these	these	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	2	dobj	_	_
5	to	to	TO	TO	_	7	case	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	measured	measure	VBD	VBD	_	2	parataxis	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-AT	nf-at	NN	NN	_	12	conj	_	_
15	activity	activity	NN	NN	_	12	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	nucleus	nucleus	NN	NN	_	10	nmod	_	_
19	after	after	IN	IN	_	21	case	_	_
20	anti-CD3	anti-cd3	JJ	JJ	_	21	amod	_	_
21	stimulation	stimulation	NN	NN	_	10	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	stimuli	stimulus	NNS	NNS	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	appearance	appearance	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	components	component	NNS	NNS	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	c-Rel	c-rel	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	p65	p65	NN	NN	_	12	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	RelA	rela	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	p50	p50	NN	NN	_	12	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B1	b1	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	)	)	-RRB-	-RRB-	_	12	punct	_	_
26	and	and	CC	CC	_	5	cc	_	_
27	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
28	B	b	NN	NN	_	31	compound	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	5	conj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	5	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	64.1	64.1	CD	CD	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	NF-AT	nf-at	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	correlating	correlate	VBG	VBG	_	5	advcl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	ability	ability	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	activate	activate	VB	VB	_	14	acl	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	16	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	NF-AT	nf-at	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	secretion	secretion	NN	NN	_	4	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	correlated	correlate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	levels	level	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	inositol	inositol	NN	NN	_	16	compound	_	_
15	phosphate	phosphate	NN	NN	_	16	compound	_	_
16	release	release	NN	NN	_	12	nmod	_	_
17	but	but	CC	CC	_	12	cc	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	with	with	IN	IN	_	21	case	_	_
20	gross	gross	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	12	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	nmod	_	_
26	induced	induce	VBN	VBN	_	25	acl	_	_
27	late	late	RB	RB	_	26	advmod	_	_
28	following	follow	VBG	VBG	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	response	response	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	13	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-2	il-2	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	conj	_	_
13	occurred	occur	VBD	VBD	_	0	root	_	_
14	even	even	RB	RB	_	20	advmod	_	_
15	with	with	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	smaller	smaller	JJR	JJR	_	20	amod	_	_
18	second	second	JJ	JJ	_	17	dep	_	_
19	messenger	messenger	NN	NN	_	20	compound	_	_
20	response	response	NN	NN	_	13	nmod	_	_
21	generated	generate	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	23	case	_	_
23	OKT3	okt3	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	trans-acting	trans-acting	JJ	JJ	_	6	amod	_	_
5	activator	activator	NN	NN	_	6	compound	_	_
6	function	function	NN	NN	_	1	nmod	_	_
7	regulating	regulate	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	CD5	cd5	NN	NN	_	14	compound	_	_
14	antigen	antigen	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Interspecies	interspecies	JJ	JJ	_	4	amod	_	_
2	somatic	somatic	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	hybrids	hybrid	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	generated	generate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	fusing	fuse	VBG	VBG	_	6	advcl	_	_
9	the	the	DT	DT	_	13	det	_	_
10	mouse	mouse	NN	NN	_	13	compound	_	_
11	T-lymphoma	t-lymphoma	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	8	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	BW5147	bw5147	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	with	with	IN	IN	_	21	case	_	_
18	normal	normal	JJ	JJ	_	21	amod	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
22	at	at	IN	IN	_	24	case	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	stages	stage	NNS	NNS	_	8	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	differentiation	differentiation	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Thymocytes	thymocyte	NNS	NNS	_	14	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	activated	activate	VBN	VBN	_	6	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	1	conj	_	_
7	,	,	,	,	_	1	punct	_	_
8	or	or	CC	CC	_	1	cc	_	_
9	an	a	DT	DT	_	12	det	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	clone	clone	NN	NN	_	1	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	0	root	_	_
15	as	as	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	partners	partner	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	respectively	respectively	RB	RB	_	14	advmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	in	in	IN	IN	_	24	case	_	_
22	three	three	CD	CD	_	24	nummod	_	_
23	independent	independent	JJ	JJ	_	24	amod	_	_
24	fusions	fusion	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Irrespective	irrespective	JJ	JJ	_	6	case	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	partner	partner	NN	NN	_	16	nmod	_	_
7	used	use	VBN	VBN	_	6	acl	_	_
8	for	for	IN	IN	_	9	case	_	_
9	fusion	fusion	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	certain	certain	JJ	JJ	_	13	amod	_	_
13	number	number	NN	NN	_	16	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	hybrids	hybrid	NNS	NNS	_	13	nmod	_	_
16	lost	lose	VBD	VBD	_	0	root	_	_
17	CD5	cd5	NN	NN	_	19	compound	_	_
18	surface	surface	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	dobj	_	_
20	over	over	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	period	period	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	time	time	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	culture	culture	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubj	_	_
2	at	at	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	phenotype	phenotype	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	genetic	genetic	JJ	JJ	_	4	conj	_	_
7	level	level	NN	NN	_	1	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	18	mark	_	_
10	lack	lack	NN	NN	_	18	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD5	cd5	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	was	be	VBD	VBD	_	18	cop	_	_
15	due	due	JJ	JJ	_	18	case	_	_
16	neither	neither	CC	CC	_	18	cc:preconj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	segregation	segregation	NN	NN	_	8	ccomp	_	_
19	of	of	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	autosome	autosome	NN	NN	_	18	nmod	_	_
22	11	11	CD	CD	_	21	nummod	_	_
23	,	,	,	,	_	21	punct	_	_
24	on	on	IN	IN	_	25	case	_	_
25	which	which	WDT	WDT	_	31	nmod	_	_
26	the	the	DT	DT	_	28	det	_	_
27	CD5	cd5	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	31	nsubjpass	_	_
29	has	have	VBZ	VBZ	_	31	aux	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	mapped	map	VBN	VBN	_	21	acl:relcl	_	_
32	,	,	,	,	_	21	punct	_	_
33	nor	nor	CC	CC	_	18	cc	_	_
34	to	to	TO	TO	_	35	case	_	_
35	deletion	deletion	NN	NN	_	18	conj	_	_
36	of	of	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	CD5	cd5	NN	NN	_	40	compound	_	_
39	structural	structural	JJ	JJ	_	40	amod	_	_
40	gene	gene	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	loss	loss	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	CD5	cd5	NN	NN	_	7	compound	_	_
6	surface	surface	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	correlated	correlate	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	absence	absence	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	hybrids	hybrid	NNS	NNS	_	5	nsubj	_	_
4	preferentially	preferentially	RB	RB	_	5	advmod	_	_
5	segregate	segregate	VBP	VBP	_	11	advcl	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	chromosomes	chromosome	NNS	NNS	_	5	dobj	_	_
8	,	,	,	,	_	11	punct	_	_
9	these	these	DT	DT	_	10	det	_	_
10	results	result	NNS	NNS	_	11	nsubj	_	_
11	indicate	indicate	VBP	VBP	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	existence	existence	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	non-syntenic	non-syntenic	JJ	JJ	_	18	amod	_	_
17	trans-active	trans-active	JJ	JJ	_	18	amod	_	_
18	locus	locus	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	or	or	CC	CC	_	18	cc	_	_
21	loci	locus	NNS	NNS	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	positively	positively	RB	RB	_	24	advmod	_	_
24	controlling	control	VBG	VBG	_	18	acl	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	CD5	cd5	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	Alpha-tocopherol	alpha-tocopherol	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	agonist-induced	agonist-induced	JJ	JJ	_	6	amod	_	_
4	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	adhesion	adhesion	NN	NN	_	2	dobj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	cultured	culture	VBN	VBN	_	11	amod	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Antioxidants	antioxidant	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	proposed	propose	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	anti-atherosclerotic	anti-atherosclerotic	JJ	JJ	_	8	amod	_	_
8	agents	agent	NNS	NNS	_	4	xcomp	_	_
9	;	;	:	:	_	4	punct	_	_
10	however	however	RB	RB	_	20	advmod	_	_
11	,	,	,	,	_	20	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	mechanisms	mechanism	NNS	NNS	_	20	nsubjpass	_	_
14	underlying	underlie	VBG	VBG	_	13	acl	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	beneficial	beneficial	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	14	dobj	_	_
18	are	be	VBP	VBP	_	20	auxpass	_	_
19	poorly	poorly	RB	RB	_	20	advmod	_	_
20	understood	understand	VBN	VBN	_	4	parataxis	_	_
21	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	alpha-tocopherol	alpha-tocopherol	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	alpha-tcp	alpha-tcp	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	on	on	IN	IN	_	14	case	_	_
12	one	one	CD	CD	_	14	nummod	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	event	event	NN	NN	_	5	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	atherosclerotic	atherosclerotic	JJ	JJ	_	18	amod	_	_
17	plaque	plaque	NN	NN	_	18	compound	_	_
18	development	development	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	monocyte	monocyte	NN	NN	_	21	compound	_	_
21	adhesion	adhesion	NN	NN	_	18	appos	_	_
22	to	to	TO	TO	_	25	case	_	_
23	stimulated	stimulate	VBN	VBN	_	25	amod	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	ECs	ec	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	umbilical	umbilical	JJ	JJ	_	4	amod	_	_
3	vein	vein	NN	NN	_	4	compound	_	_
4	ECs	ec	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	pretreated	pretreat	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	8	case	_	_
8	alpha-tcp	alpha-tcp	NN	NN	_	6	nmod	_	_
9	before	before	IN	IN	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	known	known	JJ	JJ	_	13	amod	_	_
13	agonists	agonist	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	monocyte	monocyte	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	13	nmod	_	_
17	:	:	:	:	_	6	punct	_	_
18	IL-1	il-1	NN	NN	_	6	dep	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	10	10	CD	CD	_	21	nummod	_	_
21	ng/ml	ng/ml	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	18	punct	_	_
24	LPS	lps	NN	NN	_	18	conj	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	10	10	CD	CD	_	27	nummod	_	_
27	ng/ml	ng/ml	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	18	punct	_	_
30	thrombin	thrombin	NN	NN	_	18	conj	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	30	30	CD	CD	_	33	nummod	_	_
33	U/ml	u/ml	NN	NN	_	30	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	18	punct	_	_
36	or	or	CC	CC	_	18	cc	_	_
37	PMA	pma	NN	NN	_	18	conj	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	10	10	CD	CD	_	40	nummod	_	_
40	nM	nm	NN	NN	_	37	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	.	.	.	.	_	6	punct	_	_

1	Agonist-induced	agonist-induced	JJ	JJ	_	4	amod	_	_
2	monocytic	monocytic	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	adhesion	adhesion	NN	NN	_	12	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	basal	basal	JJ	JJ	_	9	amod	_	_
9	adhesion	adhesion	NN	NN	_	4	conj	_	_
10	,	,	,	,	_	4	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	dep	_	_
15	time-	time-	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	concentration-dependent	concentration-dependent	JJ	JJ	_	15	conj	_	_
18	manner	manner	NN	NN	_	15	dep	_	_
19	by	by	IN	IN	_	20	case	_	_
20	alpha-tcp	alpha-tcp	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	IC50	ic50	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	alpha-tcp	alpha-tcp	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	IL-1-induced	il-1-induced	JJ	JJ	_	8	amod	_	_
8	response	response	NN	NN	_	2	nmod	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	45	45	CD	CD	_	11	nummod	_	_
11	microM	microm	NN	NN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	3	nsubj	_	_
3	correlated	correlate	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	decrease	decrease	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	steady	steady	JJ	JJ	_	10	amod	_	_
9	state	state	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	E-selectin	e-selectin	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	6	nmod	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	6	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	E-selectin	e-selectin	NN	NN	_	17	nmod	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	consistent	consistent	JJ	JJ	_	19	acl:relcl	_	_
23	with	with	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ability	ability	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	monoclonal	monoclonal	JJ	JJ	_	29	amod	_	_
29	antibody	antibody	NN	NN	_	25	nmod	_	_
30	to	to	TO	TO	_	31	case	_	_
31	E-selectin	e-selectin	NN	NN	_	29	nmod	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	inhibit	inhibit	VB	VB	_	25	acl	_	_
34	monocytic	monocytic	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	adhesion	adhesion	NN	NN	_	33	dobj	_	_
37	in	in	IN	IN	_	39	case	_	_
38	this	this	DT	DT	_	39	det	_	_
39	system	system	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Probucol	probucol	NN	NN	_	13	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	50	50	CD	CD	_	4	nummod	_	_
4	microM	microm	NNS	NNS	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	N-acetylcysteine	n-acetylcysteine	NN	NN	_	1	conj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	20	20	CD	CD	_	10	nummod	_	_
10	mM	mm	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	inhibited	inhibit	VBD	VBD	_	0	root	_	_
14	agonist-induced	agonist-induced	JJ	JJ	_	17	amod	_	_
15	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	13	dobj	_	_
18	;	;	:	:	_	13	punct	_	_
19	whereas	whereas	IN	IN	_	24	mark	_	_
20	,	,	,	,	_	24	punct	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	antioxidants	antioxidant	NNS	NNS	_	24	nsubj	_	_
24	had	have	VBD	VBD	_	13	advcl	_	_
25	no	no	DT	DT	_	27	neg	_	_
26	significant	significant	JJ	JJ	_	27	amod	_	_
27	effect	effect	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	13	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PKC	pkc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	appear	appear	VB	VB	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	play	play	VB	VB	_	9	xcomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	alpha-tcp	alpha-tcp	NN	NN	_	17	compound	_	_
17	effect	effect	NN	NN	_	11	nmod	_	_
18	since	since	IN	IN	_	27	mark	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	suppression	suppression	NN	NN	_	27	nsubjpass	_	_
21	of	of	IN	IN	_	22	case	_	_
22	phosphorylation	phosphorylation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	PKC	pkc	NN	NN	_	25	compound	_	_
25	substrates	substrate	NNS	NNS	_	22	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	observed	observe	VBN	VBN	_	9	advcl	_	_
28	.	.	.	.	_	9	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	5	dep	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	reported	report	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	necessary	necessary	JJ	JJ	_	9	xcomp	_	_
13	but	but	CC	CC	_	12	cc	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	sufficient	sufficient	JJ	JJ	_	12	conj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	E-selectin	e-selectin	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	EC	ec	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	show	show	VB	VB	_	5	xcomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	alpha-tcp-induced	alpha-tcp-induced	JJ	JJ	_	10	amod	_	_
10	decrease	decrease	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	this	this	DT	DT	_	16	det	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	10	nmod	_	_
17	after	after	IN	IN	_	19	case	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	stimulation	stimulation	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	alpha-tcp	alpha-tcp	NN	NN	_	7	nsubj	_	_
7	acts	act	VBZ	VBZ	_	4	ccomp	_	_
8	as	as	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	anti-atherosclerotic	anti-atherosclerotic	JJ	JJ	_	11	amod	_	_
11	molecule	molecule	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	inhibiting	inhibit	VBG	VBG	_	7	advcl	_	_
14	generation	generation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	oxidized	oxidize	VBN	VBN	_	17	amod	_	_
17	LDL	ldl	NN	NN	_	14	nmod	_	_
18	--	--	:	:	_	17	punct	_	_
19	a	a	DT	DT	_	22	det	_	_
20	putative	putative	JJ	JJ	_	22	amod	_	_
21	triggering	trigger	VBG	VBG	_	22	amod	_	_
22	molecule	molecule	NN	NN	_	17	dep	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	atherosclerotic	atherosclerotic	JJ	JJ	_	26	amod	_	_
26	process	process	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	point	point	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	alternative	alternative	NN	NN	_	8	compound	_	_
8	mechanism	mechanism	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	action	action	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	alpha-tcp	alpha-tcp	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Corticosteroid	corticosteroid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	possible	possible	JJ	JJ	_	8	amod	_	_
8	marker	marker	NN	NN	_	2	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	brain	brain	NN	NN	_	11	compound	_	_
11	involution	involution	NN	NN	_	8	nmod	_	_
12	?	?	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	similarity	similarity	NN	NN	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	recently	recently	RB	RB	_	6	advmod	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	between	between	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	corticosteroid	corticosteroid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	brain	brain	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	in	in	IN	IN	_	18	case	_	_
17	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
18	tissue	tissue	NN	NN	_	14	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	corticosteroid	corticosteroid	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	possible	possible	JJ	JJ	_	16	amod	_	_
16	marker	marker	NN	NN	_	3	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	brain	brain	NN	NN	_	19	compound	_	_
19	involution	involution	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Type	type	NN	NN	_	4	compound	_	_
2	I	i	CD	CD	_	4	nummod	_	_
3	corticosteroid	corticosteroid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	down	down	RB	RB	_	7	advmod	_	_
7	regulated	regulate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	excess	excess	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	mineralocorticoids	mineralocorticoid	NNS	NNS	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	primary	primary	JJ	JJ	_	11	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	secondary	secondary	JJ	JJ	_	13	conj	_	_
16	hyperaldosteronism	hyperaldosteronism	NN	NN	_	13	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	pseudohyperaldosteronism	pseudohyperaldosteronism	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	13	punct	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	of	of	IN	IN	_	22	case	_	_
22	glucocorticoids	glucocorticoid	NNS	NNS	_	11	conj	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	Cushing	cushing	NN	NN	_	26	nmod:poss	_	_
25	's	's	POS	POS	_	26	case	_	_
26	syndrome	syndrome	NN	NN	_	22	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	7	punct	_	_

1	Type	type	NN	NN	_	4	compound	_	_
2	II	ii	CD	CD	_	4	nummod	_	_
3	corticosteroid	corticosteroid	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	reduced	reduce	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	excess	excess	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	endogenous	endogenous	JJ	JJ	_	12	amod	_	_
12	corticosteroids	corticosteroid	NNS	NNS	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	Cushing	cushing	NN	NN	_	16	nmod:poss	_	_
15	's	's	POS	POS	_	16	case	_	_
16	syndrome	syndrome	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	normal	normal	JJ	JJ	_	3	amod	_	_
3	adults	adult	NNS	NNS	_	5	nmod	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	is	be	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	direct	direct	JJ	JJ	_	9	amod	_	_
8	significant	significant	JJ	JJ	_	7	dep	_	_
9	correlation	correlation	NN	NN	_	5	nsubj	_	_
10	between	between	IN	IN	_	12	case	_	_
11	plasma	plasma	NN	NN	_	12	compound	_	_
12	cortisol	cortisol	NN	NN	_	23	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Type	type	NN	NN	_	12	conj	_	_
15	I	i	CD	CD	_	14	nummod	_	_
16	and	and	CC	CC	_	23	cc	_	_
17	between	between	IN	IN	_	19	case	_	_
18	plasma	plasma	NN	NN	_	19	compound	_	_
19	cortisol	cortisol	NN	NN	_	23	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Type	type	NN	NN	_	19	conj	_	_
22	II	ii	CD	CD	_	21	nummod	_	_
23	receptors	receptor	NNS	NNS	_	9	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	5	punct	_	_
28	while	while	IN	IN	_	36	mark	_	_
29	in	in	IN	IN	_	32	case	_	_
30	Cushing	cushing	NN	NN	_	32	nmod:poss	_	_
31	's	's	POS	POS	_	32	case	_	_
32	syndrome	syndrome	NN	NN	_	36	nmod	_	_
33	the	the	DT	DT	_	34	det	_	_
34	correlation	correlation	NN	NN	_	36	nsubj	_	_
35	is	be	VBZ	VBZ	_	36	cop	_	_
36	inverse	inverse	JJ	JJ	_	5	advcl	_	_
37	between	between	IN	IN	_	39	case	_	_
38	plasma	plasma	NN	NN	_	39	compound	_	_
39	cortisol	cortisol	NN	NN	_	36	nmod	_	_
40	at	at	IN	IN	_	41	case	_	_
41	8	8	CD	CD	_	39	nmod	_	_
42	a.m.	a.m.	RB	RB	_	41	advmod	_	_
43	and	and	CC	CC	_	39	cc	_	_
44	Type	type	NN	NN	_	46	compound	_	_
45	II	ii	CD	CD	_	46	nummod	_	_
46	receptors	receptor	NNS	NNS	_	39	conj	_	_
47	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	an	a	DT	DT	_	4	det	_	_
3	aged	aged	JJ	JJ	_	4	amod	_	_
4	population	population	NN	NN	_	17	nmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	mean	mean	JJ	JJ	_	7	amod	_	_
7	numbers	number	NNS	NNS	_	17	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Type	type	NN	NN	_	15	nmod	_	_
10	I	i	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	15	cc	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Type	type	NN	NN	_	15	conj	_	_
14	II	ii	CD	CD	_	13	nummod	_	_
15	receptors	receptor	NNS	NNS	_	7	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	lower	lower	JJR	JJR	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	cortisol	cortisol	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	higher	higher	JJR	JJR	_	17	conj	_	_
23	than	than	IN	IN	_	26	case	_	_
24	in	in	IN	IN	_	26	case	_	_
25	adult	adult	JJ	JJ	_	26	amod	_	_
26	controls	control	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	but	but	CC	CC	_	17	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	increase	increase	NN	NN	_	36	nsubjpass	_	_
31	of	of	IN	IN	_	33	case	_	_
32	plasma	plasma	NN	NN	_	33	compound	_	_
33	cortisol	cortisol	NN	NN	_	30	nmod	_	_
34	is	be	VBZ	VBZ	_	36	auxpass	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	followed	follow	VBN	VBN	_	17	conj	_	_
37	by	by	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	clinical	clinical	JJ	JJ	_	40	amod	_	_
40	picture	picture	NN	NN	_	36	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	hypercorticism	hypercorticism	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	17	punct	_	_

1	Corticosteroid	corticosteroid	NN	NN	_	10	nsubjpass	_	_
2	Type	type	NN	NN	_	1	dep	_	_
3	I	i	CD	CD	_	2	nummod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	Type	type	NN	NN	_	1	conj	_	_
6	II	ii	CD	CD	_	5	nummod	_	_
7	receptors	receptor	NNS	NNS	_	1	dep	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	inversely	inversely	RB	RB	_	10	advmod	_	_
10	correlated	correlate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	age	age	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	dexamethasone	dexamethasone	NN	NN	_	3	compound	_	_
3	suppression	suppression	NN	NN	_	15	nmod	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	mg	mg	NN	NN	_	3	dep	_	_
7	at	at	IN	IN	_	9	case	_	_
8	11	11	CD	CD	_	9	nummod	_	_
9	p.m.	p.m.	NN	NN	_	6	nmod	_	_
10	)	)	-RRB-	-RRB-	_	6	punct	_	_
11	Type	type	NN	NN	_	13	compound	_	_
12	I	i	CD	CD	_	13	nummod	_	_
13	receptors	receptor	NNS	NNS	_	15	nsubj	_	_
14	always	always	RB	RB	_	15	advmod	_	_
15	decrease	decrease	VBP	VBP	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	controls	control	NNS	NNS	_	15	nmod	_	_
18	while	while	IN	IN	_	26	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	response	response	NN	NN	_	26	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Type	type	NN	NN	_	20	nmod	_	_
23	II	ii	CD	CD	_	22	nummod	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	homogeneous	homogeneous	JJ	JJ	_	15	advcl	_	_
27	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	an	a	DT	DT	_	4	det	_	_
3	aged	aged	JJ	JJ	_	4	amod	_	_
4	group	group	NN	NN	_	11	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	both	both	DT	DT	_	9	det	_	_
9	receptors	receptor	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	reduced	reduce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	dexamethasone	dexamethasone	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	decrease	decrease	NN	NN	_	13	nsubj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	age	age	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	corticosteroid	corticosteroid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	possibly	possibly	RB	RB	_	13	advmod	_	_
13	related	related	JJ	JJ	_	2	ccomp	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	physiological	physiological	JJ	JJ	_	17	amod	_	_
17	involution	involution	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	corticosteroid	corticosteroid	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	this	this	DT	DT	_	24	det	_	_
24	reduction	reduction	NN	NN	_	26	nsubj	_	_
25	does	do	VBZ	VBZ	_	26	aux	_	_
26	increase	increase	VB	VB	_	13	conj	_	_
27	plasma	plasma	NN	NN	_	29	compound	_	_
28	cortisol	cortisol	NN	NN	_	29	compound	_	_
29	concentration	concentration	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	26	punct	_	_
31	without	without	IN	IN	_	32	mark	_	_
32	affecting	affect	VBG	VBG	_	26	advcl	_	_
33	the	the	DT	DT	_	36	det	_	_
34	glucocorticoid	glucocorticoid	NN	NN	_	36	compound	_	_
35	effector	effector	NN	NN	_	36	compound	_	_
36	mechanism	mechanism	NN	NN	_	32	dobj	_	_
37	.	.	.	.	_	2	punct	_	_

1	Mitogen	mitogen	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	formation	formation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	19	case	_	_
12	new	new	JJ	JJ	_	19	amod	_	_
13	cyclic	cyclic	JJ	JJ	_	19	amod	_	_
14	AMP	amp	NN	NN	_	19	compound	_	_
15	response	response	NN	NN	_	19	compound	_	_
16	element-binding	element-binding	JJ	JJ	_	19	amod	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	large	large	JJ	JJ	_	3	amod	_	_
3	body	body	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	evidence	evidence	NN	NN	_	3	nmod	_	_
6	indicates	indicate	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	experimental	experimental	JJ	JJ	_	9	amod	_	_
9	agents	agent	NNS	NNS	_	15	nsubj	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	raise	raise	VBP	VBP	_	9	acl:relcl	_	_
12	cellular	cellular	JJ	JJ	_	14	amod	_	_
13	cAMP	camp	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	11	dobj	_	_
15	inhibit	inhibit	VBP	VBP	_	6	ccomp	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cell	cell	NN	NN	_	15	dobj	_	_
18	growth	growth	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	division	division	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	many	many	JJ	JJ	_	5	amod	_	_
5	studies	study	NNS	NNS	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	reported	report	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	mitogen	mitogen	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	increases	increase	VBZ	VBZ	_	7	ccomp	_	_
15	cAMP	camp	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	14	dobj	_	_
17	,	,	,	,	_	14	punct	_	_
18	implying	imply	VBG	VBG	_	14	advcl	_	_
19	a	a	DT	DT	_	22	det	_	_
20	positive	positive	JJ	JJ	_	22	amod	_	_
21	physiological	physiological	JJ	JJ	_	20	dep	_	_
22	role	role	NN	NN	_	18	dobj	_	_
23	for	for	IN	IN	_	24	case	_	_
24	cAMP	camp	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	activation	activation	NN	NN	_	28	compound	_	_
28	process	process	NN	NN	_	18	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	mitogen	mitogen	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	15	nsubj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
15	induces	induce	VBZ	VBZ	_	6	ccomp	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	15	dobj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	form	form	VBP	VBP	_	17	acl:relcl	_	_
20	complexes	complex	NNS	NNS	_	19	dobj	_	_
21	with	with	IN	IN	_	26	case	_	_
22	cyclic	cyclic	JJ	JJ	_	26	amod	_	_
23	AMP	amp	NN	NN	_	26	compound	_	_
24	response	response	NN	NN	_	26	compound	_	_
25	element-binding	element-binding	JJ	JJ	_	26	amod	_	_
26	protein	protein	NN	NN	_	19	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CREB	creb	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	6	punct	_	_

1	Four	four	CD	CD	_	2	nummod	_	_
2	complexes	complex	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	two	two	CD	CD	_	16	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	12	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	10	acl:relcl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	mitogen	mitogen	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	four	four	CD	CD	_	3	nummod	_	_
3	complexes	complex	NNS	NNS	_	4	nsubj	_	_
4	contain	contain	VBP	VBP	_	0	root	_	_
5	CREB	creb	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	bound	bind	VBN	VBN	_	4	conj	_	_
9	to	to	TO	TO	_	18	case	_	_
10	the	the	DT	DT	_	18	det	_	_
11	cAMP	camp	NN	NN	_	18	compound	_	_
12	response	response	NN	NN	_	18	compound	_	_
13	element	element	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	CRE	cre	NN	NN	_	18	compound	_	_
16	)	)	-RRB-	-RRB-	_	18	punct	_	_
17	core	core	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	8	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TGACGTCA	tgacgtca	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	4	punct	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	indicated	indicate	VBN	VBN	_	4	advcl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	antibody	antibody	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	oligonucleotide	oligonucleotide	NN	NN	_	26	conj	_	_
29	competition	competition	NN	NN	_	30	compound	_	_
30	experiments	experiment	NNS	NNS	_	26	dep	_	_
31	.	.	.	.	_	4	punct	_	_

1	Binding	binding	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	four	four	CD	CD	_	5	nummod	_	_
5	complexes	complex	NNS	NNS	_	1	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	CRE	cre	NN	NN	_	1	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	prevented	prevent	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	dephosphorylation	dephosphorylation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	restored	restore	VBN	VBN	_	9	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	rephosphorylation	rephosphorylation	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	cAMP-dependent	camp-dependent	JJ	JJ	_	23	amod	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	19	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	endogenous	endogenous	JJ	JJ	_	26	amod	_	_
26	kinases	kinase	NNS	NNS	_	23	conj	_	_
27	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	complexes	complex	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Jurkat	jurkat	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Mitogen	mitogen	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	electrophoretic	electrophoretic	JJ	JJ	_	9	amod	_	_
6	mobility	mobility	NN	NN	_	9	compound	_	_
7	shift	shift	NN	NN	_	9	compound	_	_
8	assay	assay	NN	NN	_	9	compound	_	_
9	complexes	complex	NNS	NNS	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	accounted	account	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	by	by	IN	IN	_	16	case	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	12	dep	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	by	by	IN	IN	_	19	case	_	_
19	induction	induction	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CREB	creb	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Rather	rather	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	mitogen	mitogen	NN	NN	_	8	nsubj	_	_
8	increases	increase	VBZ	VBZ	_	5	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	levels	level	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
14	factor	factor	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	s	s	NNS	NNS	_	10	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	dimerizes	dimerize	VBZ	VBZ	_	16	acl:relcl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	CREB	creb	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Induction	induction	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	new	new	JJ	JJ	_	5	amod	_	_
4	CREB	creb	NN	NN	_	5	compound	_	_
5	complexes	complex	NNS	NNS	_	1	nmod	_	_
6	implies	imply	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	physiological	physiological	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	cAMP	camp	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	mitogen	mitogen	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	homeobox	homeobox	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	11	nsubjpass	_	_
6	distantly	distantly	RB	RB	_	7	advmod	_	_
7	related	related	JJ	JJ	_	5	amod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	proboscipedia	proboscipedia	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	lymphoid	lymphoid	JJ	JJ	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	pancreatic	pancreatic	JJ	JJ	_	13	conj	_	_
16	tissues	tissue	NNS	NNS	_	13	dep	_	_
17	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	homeobox	homeobox	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	10	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	HB9	hb9	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	isolated	isolate	VBN	VBN	_	0	root	_	_
11	from	from	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cDNA	cdna	NN	NN	_	14	compound	_	_
14	library	library	NN	NN	_	10	nmod	_	_
15	prepared	prepare	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	23	case	_	_
17	in	in	FW	FW	_	23	compound	_	_
18	vitro	vitro	FW	FW	_	23	compound	_	_
19	stimulated	stimulate	VBN	VBN	_	23	amod	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	tonsil	tonsil	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	from	from	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	genomic	genomic	JJ	JJ	_	29	amod	_	_
29	library	library	NN	NN	_	23	conj	_	_
30	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HB9	hb9	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	composed	compose	VBN	VBN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	3	3	CD	CD	_	8	nummod	_	_
8	exons	exon	NNS	NNS	_	5	nmod	_	_
9	spread	spread	VBN	VBN	_	8	acl	_	_
10	over	over	IN	IN	_	12	case	_	_
11	6	6	CD	CD	_	12	nummod	_	_
12	kilobases	kilobase	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	DNA	dna	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	open	open	JJ	JJ	_	4	amod	_	_
3	reading	reading	NN	NN	_	4	compound	_	_
4	frame	frame	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	1206	1206	CD	CD	_	7	nummod	_	_
7	nucleotides	nucleotide	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	in	in	IN	IN	_	10	case	_	_
10	frame	frame	NN	NN	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	diverged	diverged	JJ	JJ	_	14	amod	_	_
14	homeodomain	homeodomain	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	predicted	predict	VBN	VBN	_	4	amod	_	_
3	HB9	hb9	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	molecular	molecular	JJ	JJ	_	8	amod	_	_
8	mass	mass	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	41	41	CD	CD	_	11	nummod	_	_
11	kilodaltons	kilodalton	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	enriched	enriched	JJ	JJ	_	5	conj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	alanine	alanine	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	glycine	glycine	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	leucine	leucine	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HB9	hb9	NN	NN	_	3	compound	_	_
3	homeodomain	homeodomain	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	most	most	RBS	RBS	_	6	advmod	_	_
6	similar	similar	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	that	that	DT	DT	_	6	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	Drosophila	drosophila	FW	FW	_	14	compound	_	_
12	melanogaster	melanogaster	FW	FW	_	14	compound	_	_
13	homeobox	homeobox	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	8	nmod	_	_
15	proboscipedia	proboscipedia	NN	NN	_	14	dep	_	_
16	.	.	.	.	_	6	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	21	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	poly(A)	poly(a)	NN	NN	_	6	compound	_	_
6	RNA	rna	NN	NN	_	3	nmod	_	_
7	purified	purify	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	line	line	NN	NN	_	14	compound	_	_
14	RPMI	rpmi	NN	NN	_	7	nmod	_	_
15	8226	8226	CD	CD	_	14	nummod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	from	from	IN	IN	_	20	case	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	conj	_	_
21	revealed	reveal	VBD	VBD	_	0	root	_	_
22	a	a	DT	DT	_	25	det	_	_
23	major	major	JJ	JJ	_	25	amod	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	transcript	transcript	NN	NN	_	21	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	2.2	2.2	CD	CD	_	28	nummod	_	_
28	kilobases	kilobase	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	poly(A)	poly(a)	NN	NN	_	5	compound	_	_
5	RNA	rna	NN	NN	_	2	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	variety	variety	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	adult	adult	JJ	JJ	_	11	amod	_	_
11	tissues	tissue	NNS	NNS	_	8	nmod	_	_
12	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
13	HB9	hb9	NN	NN	_	14	compound	_	_
14	transcripts	transcript	NNS	NNS	_	12	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	pancreas	pancreas	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	small	small	JJ	JJ	_	19	amod	_	_
19	intestine	intestine	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	colon	colon	NN	NN	_	16	conj	_	_
23	.	.	.	.	_	12	punct	_	_

1	Reverse	reverse	JJ	JJ	_	4	amod	_	_
2	transcriptase-polymerase	transcriptase-polymerase	JJ	JJ	_	1	dep	_	_
3	chain	chain	NN	NN	_	4	compound	_	_
4	reaction	reaction	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	examine	examine	VB	VB	_	6	xcomp	_	_
9	HB9	hb9	NN	NN	_	11	compound	_	_
10	RNA	rna	NN	NN	_	11	compound	_	_
11	transcripts	transcript	NNS	NNS	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	hematopoietic	hematopoietic	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	HB9	hb9	NN	NN	_	3	compound	_	_
2	RNA	rna	NN	NN	_	3	compound	_	_
3	transcripts	transcript	NNS	NNS	_	6	nsubj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	most	most	RBS	RBS	_	6	advmod	_	_
6	prevalent	prevalent	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	12	case	_	_
8	several	several	JJ	JJ	_	12	amod	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	K562	k562	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	transcripts	transcript	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	RNA	rna	NN	NN	_	6	nmod	_	_
9	prepared	prepare	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	13	case	_	_
11	tonsil	tonsil	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	in	in	FW	FW	_	18	amod	_	_
16	situ	situ	FW	FW	_	15	dep	_	_
17	hybridization	hybridization	NN	NN	_	18	compound	_	_
18	studies	study	NNS	NNS	_	19	nsubj	_	_
19	localized	localize	VBD	VBD	_	6	conj	_	_
20	them	they	PRP	PRP	_	19	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	germinal	germinal	JJ	JJ	_	25	amod	_	_
24	center	center	NN	NN	_	25	compound	_	_
25	region	region	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	adult	adult	JJ	JJ	_	28	amod	_	_
28	tonsil	tonsil	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HB9	hb9	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	regulating	regulate	VBG	VBG	_	5	acl	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	lymphoid	lymphoid	JJ	JJ	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	pancreatic	pancreatic	JJ	JJ	_	13	conj	_	_
16	tissues	tissue	NNS	NNS	_	13	dep	_	_
17	.	.	.	.	_	3	punct	_	_

1	ZAP-70	zap-70	NN	NN	_	3	compound	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	kinase	kinase	NN	NN	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	CD45	cd45	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	3	conj	_	_
11	involvement	involvement	NN	NN	_	3	dep	_	_
12	in	in	IN	IN	_	13	case	_	_
13	UV-	uv-	NN	NN	_	3	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	H2O2-induced	h2o2-induced	JJ	JJ	_	13	conj	_	_
16	T	t	NN	NN	_	19	compound	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	signal	signal	NN	NN	_	19	compound	_	_
19	transduction	transduction	NN	NN	_	13	dep	_	_
20	.	.	.	.	_	3	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	mammalian	mammalian	JJ	JJ	_	3	amod	_	_
3	responses	response	NNS	NNS	_	16	nsubjpass	_	_
4	to	to	TO	TO	_	6	case	_	_
5	UV	uv	NN	NN	_	6	compound	_	_
6	irradiation	irradiation	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	including	include	VBG	VBG	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	believed	believe	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	involve	involve	VB	VB	_	16	xcomp	_	_
19	tyrosine	tyrosine	NN	NN	_	20	compound	_	_
20	phosphorylation	phosphorylation	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	16	punct	_	_

1	UV	uv	NN	NN	_	2	compound	_	_
2	irradiation	irradiation	NN	NN	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	H2O2	h2o2	NN	NN	_	5	compound	_	_
5	treatment	treatment	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
9	induce	induce	VBP	VBP	_	0	root	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Ca2+	ca2+	NN	NN	_	15	compound	_	_
15	signals	signal	NNS	NNS	_	12	conj	_	_
16	similar	similar	JJ	JJ	_	12	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	those	those	DT	DT	_	16	nmod	_	_
19	observed	observe	VBN	VBN	_	18	acl	_	_
20	following	follow	VBG	VBG	_	22	case	_	_
21	biological	biological	JJ	JJ	_	22	amod	_	_
22	stimulation	stimulation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	surface	surface	NN	NN	_	9	compound	_	_
9	molecules	molecule	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	responses	response	NNS	NNS	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Normal	normal	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	11	nsubj	_	_
4	whose	whose	WP$	WP$	_	6	nmod:poss	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CD3	cd3	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	depleted	deplete	VBN	VBN	_	3	acl:relcl	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	impaired	impaired	JJ	JJ	_	15	amod	_	_
13	UV-induced	uv-induced	JJ	JJ	_	12	dep	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Ca2+	ca2+	NN	NN	_	18	compound	_	_
18	signals	signal	NNS	NNS	_	15	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	Similarly	similarly	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	Jurkat	jurkat	NN	NN	_	6	compound	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	14	nsubj	_	_
7	deficient	deficient	JJ	JJ	_	6	amod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	CD3	cd3	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	CD45	cd45	NN	NN	_	9	conj	_	_
12	expression	expression	NN	NN	_	9	dep	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	gave	give	VBD	VBD	_	0	root	_	_
15	impaired	impaired	JJ	JJ	_	17	amod	_	_
16	UV	uv	NN	NN	_	17	compound	_	_
17	responses	response	NNS	NNS	_	14	dobj	_	_
18	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	all	all	PDT	PDT	_	6	det:predet	_	_
4	these	these	DT	DT	_	6	det	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	types	type	NNS	NNS	_	8	nsubj	_	_
7	still	still	RB	RB	_	8	advmod	_	_
8	gave	give	VBD	VBD	_	0	root	_	_
9	strong	strong	JJ	JJ	_	10	amod	_	_
10	Ca2+	ca2+	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	conj	_	_
14	responses	response	NNS	NNS	_	10	dep	_	_
15	to	to	TO	TO	_	16	case	_	_
16	H2O2	h2o2	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	T	t	NN	NN	_	6	compound	_	_
3	cell	cell	NN	NN	_	6	compound	_	_
4	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	ZAP-70	zap-70	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	responsive	responsive	JJ	JJ	_	8	xcomp	_	_
13	to	to	TO	TO	_	14	case	_	_
14	UV	uv	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	H2O2	h2o2	NN	NN	_	14	conj	_	_
17	treatment	treatment	NN	NN	_	14	dep	_	_
18	.	.	.	.	_	8	punct	_	_

1	ZAP-70	zap-70	NN	NN	_	2	compound	_	_
2	responsiveness	responsiveness	NN	NN	_	5	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	UV	uv	NN	NN	_	2	nmod	_	_
5	required	require	VBD	VBD	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	CD3	cd3	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CD45	cd45	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	whereas	whereas	IN	IN	_	17	mark	_	_
14	only	only	JJ	JJ	_	15	amod	_	_
15	CD3	cd3	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	5	advcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	response	response	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	H2O2	h2o2	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	UV-induced	uv-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	CD3	cd3	NN	NN	_	10	compound	_	_
10	depletion	depletion	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	indicating	indicate	VBG	VBG	_	7	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	importance	importance	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	such	such	JJ	JJ	_	19	amod	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	surface	surface	NN	NN	_	19	compound	_	_
19	molecules	molecule	NNS	NNS	_	14	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	biological	biological	JJ	JJ	_	22	amod	_	_
22	responses	response	NNS	NNS	_	14	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	UV	uv	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	nonlymphoid	nonlymphoid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	9	det	_	_
6	epidermal	epidermal	JJ	JJ	_	9	amod	_	_
7	growth	growth	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	10	nsubj	_	_
10	displayed	display	VBD	VBD	_	0	root	_	_
11	increased	increase	VBN	VBN	_	13	amod	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
14	within	within	IN	IN	_	15	case	_	_
15	seconds	seconds	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	UV	uv	NN	NN	_	18	compound	_	_
18	irradiation	irradiation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	UV-induced	uv-induced	JJ	JJ	_	7	amod	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transduction	transduction	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
10	via	via	IN	IN	_	13	case	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	9	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	normally	normally	RB	RB	_	16	advmod	_	_
16	respond	respond	VBP	VBP	_	13	acl:relcl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	biological	biological	JJ	JJ	_	19	amod	_	_
19	stimulation	stimulation	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	whereas	whereas	IN	IN	_	24	mark	_	_
22	H2O2	h2o2	NN	NN	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	able	able	JJ	JJ	_	9	advcl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	partially	partially	RB	RB	_	24	nmod	_	_
27	bypass	bypass	VB	VB	_	26	dep	_	_
28	this	this	DT	DT	_	29	det	_	_
29	requirement	requirement	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	sodium	sodium	NN	NN	_	7	compound	_	_
7	salicylate	salicylate	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	aspirin	aspirin	NN	NN	_	7	conj	_	_
10	-LSB-	-lsb-	-LRB-	-LRB-	_	11	punct	_	_
11	see	see	VB	VB	_	1	dep	_	_
12	comments	comment	NNS	NNS	_	11	dobj	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	12	nsubj	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	dep	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	critical	critical	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	inducible	inducible	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	multiple	multiple	JJ	JJ	_	16	nmod	_	_
19	cellular	cellular	JJ	JJ	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	viral	viral	JJ	JJ	_	18	conj	_	_
22	genes	gene	NNS	NNS	_	18	dep	_	_
23	involved	involve	VBN	VBN	_	18	acl	_	_
24	in	in	IN	IN	_	25	case	_	_
25	inflammation	inflammation	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	infection	infection	NN	NN	_	25	conj	_	_
28	including	include	VBG	VBG	_	25	acl	_	_
29	interleukin-1	interleukin-1	NN	NN	_	28	dobj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	IL-1	il-1	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	29	punct	_	_
34	IL-6	il-6	NN	NN	_	29	conj	_	_
35	,	,	,	,	_	29	punct	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	adhesion	adhesion	NN	NN	_	38	compound	_	_
38	molecules	molecule	NNS	NNS	_	29	conj	_	_
39	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	anti-inflammatory	anti-inflammatory	JJ	JJ	_	3	amod	_	_
3	drugs	drug	NNS	NNS	_	8	nsubj	_	_
4	sodium	sodium	NN	NN	_	5	compound	_	_
5	salicylate	salicylate	NN	NN	_	3	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	aspirin	aspirin	NN	NN	_	5	conj	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	further	further	RB	RB	_	17	advmod	_	_
17	explains	explain	VBZ	VBZ	_	8	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	mechanism	mechanism	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	action	action	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	drugs	drug	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	3	nsubj	_	_
3	prevented	prevent	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	degradation	degradation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	inhibitor	inhibitor	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	I	i	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	appos	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	therefore	therefore	RB	RB	_	21	advmod	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	retained	retain	VBN	VBN	_	3	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cytosol	cytosol	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Sodium	sodium	NN	NN	_	2	compound	_	_
2	salicylate	salicylate	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	aspirin	aspirin	NN	NN	_	2	conj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B-dependent	b-dependent	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	from	from	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	Ig	ig	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	the	the	DT	DT	_	25	det	_	_
17	human	human	JJ	JJ	_	25	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	25	compound	_	_
19	virus	virus	NN	NN	_	25	compound	_	_
20	(	(	-LRB-	-LRB-	_	25	punct	_	_
21	HIV	hiv	NN	NN	_	25	compound	_	_
22	)	)	-RRB-	-RRB-	_	25	punct	_	_
23	long	long	JJ	JJ	_	25	amod	_	_
24	terminal	terminal	JJ	JJ	_	25	amod	_	_
25	repeat	repeat	NN	NN	_	9	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	LTR	ltr	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	32	case	_	_
30	transfected	transfect	VBN	VBN	_	32	amod	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	differentiation	differentiation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	4	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	redox	redox	NN	NN	_	12	compound	_	_
12	changes	change	NNS	NNS	_	1	nmod	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	through	through	IN	IN	_	16	case	_	_
15	glutathione	glutathione	NN	NN	_	16	compound	_	_
16	depletion	depletion	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	redox	redox	NN	NN	_	8	compound	_	_
8	changes	change	NNS	NNS	_	5	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vivo	vivo	FW	FW	_	5	advmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	differentiation	differentiation	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	two	two	CD	CD	_	19	nummod	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	HL-60	hl-60	NN	NN	_	19	appos	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	KG-1	kg-1	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	glutathione-depleting	glutathione-depleting	JJ	JJ	_	5	amod	_	_
3	agent	agent	NN	NN	_	5	compound	_	_
4	diethyl	diethyl	NN	NN	_	5	compound	_	_
5	maleate	maleate	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DEM	dem	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	prevented	prevent	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	development	development	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	differentiated	differentiate	VBN	VBN	_	14	amod	_	_
14	features	feature	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	response	response	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	esters	ester	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	including	include	VBG	VBG	_	22	case	_	_
22	adherence	adherence	NN	NN	_	11	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	plastic	plastic	JJ	JJ	_	28	amod	_	_
28	surfaces	surface	NNS	NNS	_	22	nmod	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	repression	repression	NN	NN	_	22	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	dep	_	_
33	myeloperoxidase	myeloperoxidase	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	CD34	cd34	NN	NN	_	33	conj	_	_
36	genes	gene	NNS	NNS	_	33	dep	_	_
37	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	DEM	dem	NN	NN	_	4	nsubj	_	_
4	abolished	abolish	VBD	VBD	_	0	root	_	_
5	phorbol	phorbol	NN	NN	_	8	compound	_	_
6	12-myristate	12-myristate	NN	NN	_	8	compound	_	_
7	13-acetate-induced	13-acetate-induced	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	AP-1	ap-1	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Egr-1	egr-1	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	inhibition	inhibition	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	differentiation	differentiation	NN	NN	_	19	nmod	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	due	due	JJ	JJ	_	17	ccomp	_	_
25	,	,	,	,	_	24	punct	_	_
26	at	at	IN	IN	_	29	advmod	_	_
27	least	least	JJS	JJS	_	26	mwe	_	_
28	in	in	IN	IN	_	29	case	_	_
29	part	part	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	24	punct	_	_
31	to	to	TO	TO	_	33	case	_	_
32	redox	redox	NN	NN	_	33	compound	_	_
33	modifications	modification	NNS	NNS	_	24	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	proteins	protein	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	rheumatoid	rheumatoid	JJ	JJ	_	6	amod	_	_
6	arthritis	arthritis	NN	NN	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Diminished	diminish	VBN	VBN	_	3	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	6	nsubj	_	_
4	do	do	VBP	VBP	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	result	result	VB	VB	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	resistance	resistance	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	patients	patient	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	rheumatoid	rheumatoid	JJ	JJ	_	6	amod	_	_
6	arthritis	arthritis	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	RA	ra	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	have	have	VBP	VBP	_	0	root	_	_
11	diminished	diminish	VBN	VBN	_	13	amod	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	density	density	NN	NN	_	10	dobj	_	_
14	;	;	:	:	_	10	punct	_	_
15	thus	thus	RB	RB	_	21	advmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	patients	patient	NNS	NNS	_	21	nsubj	_	_
18	with	with	IN	IN	_	19	case	_	_
19	RA	ra	NN	NN	_	17	nmod	_	_
20	should	should	MD	MD	_	21	aux	_	_
21	show	show	VB	VB	_	10	parataxis	_	_
22	partial	partial	JJ	JJ	_	23	amod	_	_
23	resistance	resistance	NN	NN	_	21	dobj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	glucocorticoids	glucocorticoid	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	sensitivity	sensitivity	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	RA	ra	NN	NN	_	10	compound	_	_
10	patients	patient	NNS	NNS	_	7	nmod	_	_
11	compared	compare	VBN	VBN	_	14	case	_	_
12	with	with	IN	IN	_	14	case	_	_
13	healthy	healthy	JJ	JJ	_	14	amod	_	_
14	subjects	subject	NNS	NNS	_	2	advcl	_	_
15	.	.	.	.	_	2	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	determined	determine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	glucocorticoids	glucocorticoid	NNS	NNS	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	proliferation	proliferation	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	release	release	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Proliferation	proliferation	NN	NN	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	release	release	NN	NN	_	1	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	inhibited	inhibit	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	RA	ra	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	same	same	JJ	JJ	_	13	amod	_	_
13	extent	extent	NN	NN	_	6	nmod	_	_
14	as	as	IN	IN	_	17	case	_	_
15	in	in	IN	IN	_	17	case	_	_
16	healthy	healthy	JJ	JJ	_	17	amod	_	_
17	controls	control	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	.	.	.	.	_	1	punct	_	_

1	Diminished	diminish	VBN	VBN	_	3	amod	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	density	density	NN	NN	_	9	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	RA	ra	NN	NN	_	6	compound	_	_
6	patients	patient	NNS	NNS	_	3	nmod	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	result	result	VB	VB	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	resistance	resistance	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Positive	positive	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	negative	negative	JJ	JJ	_	1	conj	_	_
4	regulation	regulation	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-2	il-2	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	:	:	:	:	_	1	punct	_	_
10	role	role	NN	NN	_	1	dep	_	_
11	of	of	IN	IN	_	14	case	_	_
12	multiple	multiple	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	sites	site	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Interleukin	interleukin	NN	NN	_	9	nsubj	_	_
2	2	2	CD	CD	_	1	nummod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-2	il-2	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	lymphokine	lymphokine	NN	NN	_	0	root	_	_
10	required	require	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	process	process	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cell	cell	NN	NN	_	13	nmod	_	_
17	activation	activation	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	16	punct	_	_
19	proliferation	proliferation	NN	NN	_	16	appos	_	_
20	,	,	,	,	_	16	punct	_	_
21	clonal	clonal	JJ	JJ	_	22	amod	_	_
22	expansion	expansion	NN	NN	_	16	appos	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	differentiation	differentiation	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	displays	display	VBZ	VBZ	_	0	root	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cell	cell	NN	NN	_	4	dobj	_	_
8	specific	specific	JJ	JJ	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	inducible	inducible	JJ	JJ	_	7	conj	_	_
11	expression	expression	NN	NN	_	7	dep	_	_
12	:	:	:	:	_	4	punct	_	_
13	it	it	PRP	PRP	_	16	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	only	only	RB	RB	_	16	advmod	_	_
16	expressed	express	VBN	VBN	_	4	parataxis	_	_
17	in	in	IN	IN	_	20	case	_	_
18	CD4+	cd4+	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	after	after	IN	IN	_	22	case	_	_
22	antigenic	antigenic	JJ	JJ	_	16	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	mitogenic	mitogenic	JJ	JJ	_	22	conj	_	_
25	stimulation	stimulation	NN	NN	_	22	dep	_	_
26	.	.	.	.	_	4	punct	_	_

1	Several	several	JJ	JJ	_	4	amod	_	_
2	cis-acting	cis-acting	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	induction	induction	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	stimulation	stimulation	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	analysed	analyse	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	function	function	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	these	these	DT	DT	_	14	det	_	_
12	cis-acting	cis-acting	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	sites	site	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	context	context	NN	NN	_	7	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	dep	_	_
20	native	native	JJ	JJ	_	22	amod	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	enhancer	enhancer	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	NFAT	nfat	NN	NN	_	6	ccomp	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	-276	-276	CD	CD	_	13	nummod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	-261	-261	CD	CD	_	9	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	9	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	distal	distal	JJ	JJ	_	18	amod	_	_
18	octamer	octamer	NN	NN	_	9	conj	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	-256	-256	CD	CD	_	22	nummod	_	_
21	to	to	TO	TO	_	22	dep	_	_
22	-248	-248	CD	CD	_	18	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	the	the	DT	DT	_	27	det	_	_
26	proximal	proximal	JJ	JJ	_	27	amod	_	_
27	octamer	octamer	NN	NN	_	9	conj	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	-75	-75	CD	CD	_	31	nummod	_	_
30	to	to	TO	TO	_	31	dep	_	_
31	-66	-66	CD	CD	_	27	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	sites	site	NNS	NNS	_	9	dep	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	only	only	RB	RB	_	9	dep	_	_
36	act	act	VBP	VBP	_	9	conj	_	_
37	as	as	IN	IN	_	38	case	_	_
38	enhancers	enhancer	NNS	NNS	_	36	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	IL-2	il-2	NN	NN	_	42	compound	_	_
41	gene	gene	NN	NN	_	42	compound	_	_
42	transcription	transcription	NN	NN	_	38	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	presence	presence	NN	NN	_	36	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	cellular	cellular	JJ	JJ	_	48	amod	_	_
48	stimulation	stimulation	NN	NN	_	45	nmod	_	_
49	,	,	,	,	_	36	punct	_	_
50	but	but	CC	CC	_	36	cc	_	_
51	also	also	RB	RB	_	52	advmod	_	_
52	have	have	VBP	VBP	_	36	conj	_	_
53	a	a	DT	DT	_	55	det	_	_
54	silencing	silencing	JJ	JJ	_	55	amod	_	_
55	effect	effect	NN	NN	_	52	dobj	_	_
56	on	on	IN	IN	_	59	case	_	_
57	IL-2	il-2	NN	NN	_	59	compound	_	_
58	gene	gene	NN	NN	_	59	compound	_	_
59	expression	expression	NN	NN	_	55	nmod	_	_
60	in	in	IN	IN	_	62	case	_	_
61	resting	rest	VBG	VBG	_	62	amod	_	_
62	cells	cell	NNS	NNS	_	59	nmod	_	_
63	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	sites	site	NNS	NNS	_	4	nsubj	_	_
4	display	display	VBP	VBP	_	0	root	_	_
5	disparate	disparate	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	4	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	IL-2	il-2	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	different	different	JJ	JJ	_	16	amod	_	_
13	T	t	NN	NN	_	16	compound	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	10	nmod	_	_
17	:	:	:	:	_	4	punct	_	_
18	the	the	DT	DT	_	21	det	_	_
19	distal	distal	JJ	JJ	_	21	amod	_	_
20	purine	purine	NN	NN	_	21	compound	_	_
21	box	box	NN	NN	_	4	dep	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	-291	-291	CD	CD	_	25	nummod	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	-277	-277	CD	CD	_	21	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	the	the	DT	DT	_	31	det	_	_
29	proximal	proximal	JJ	JJ	_	31	amod	_	_
30	purine	purine	NN	NN	_	31	compound	_	_
31	box	box	NN	NN	_	21	conj	_	_
32	sites	site	NNS	NNS	_	31	dep	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	-145	-145	CD	CD	_	36	nummod	_	_
35	to	to	TO	TO	_	36	dep	_	_
36	-128	-128	CD	CD	_	31	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	AP-1	ap-1	NN	NN	_	20	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	-186	-186	CD	CD	_	8	nummod	_	_
7	to	to	TO	TO	_	8	dep	_	_
8	-176	-176	CD	CD	_	4	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	kappa	kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	4	conj	_	_
14	sites	site	NNS	NNS	_	13	dep	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	-206	-206	CD	CD	_	18	nummod	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	-195	-195	CD	CD	_	13	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	respond	respond	VBP	VBP	_	0	root	_	_
21	to	to	TO	TO	_	24	case	_	_
22	different	different	JJ	JJ	_	24	amod	_	_
23	cellular	cellular	JJ	JJ	_	22	dep	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	EL4	el4	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	AP-1	ap-1	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	4	nsubj	_	_
4	mediated	mediate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	response	response	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	PMA	pma	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	6	nmod	_	_
10	while	while	IN	IN	_	15	mark	_	_
11	the	the	DT	DT	_	14	det	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	15	nsubj	_	_
15	responded	respond	VBD	VBD	_	4	advcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	IL-1	il-1	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regulation	regulation	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	IL-2	il-2	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	complex	complex	JJ	JJ	_	14	amod	_	_
14	process	process	NN	NN	_	3	ccomp	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	multiple	multiple	JJ	JJ	_	19	amod	_	_
17	cis-acting	cis-acting	JJ	JJ	_	19	amod	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	sites	site	NNS	NNS	_	20	nsubj	_	_
20	interact	interact	VBP	VBP	_	14	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	exert	exert	VB	VB	_	20	xcomp	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	effects	effect	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	representative	representative	JJ	JJ	_	27	amod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	alternative	alternative	JJ	JJ	_	31	amod	_	_
31	stages	stage	NNS	NNS	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	differentiation	differentiation	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Upregulation	upregulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	bcl-2	bcl-2	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	10	amod	_	_
7	virus	virus	NN	NN	_	10	compound	_	_
8	latent	latent	JJ	JJ	_	10	amod	_	_
9	membrane	membrane	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	1	nmod	_	_
11	LMP1	lmp1	NN	NN	_	10	dep	_	_
12	:	:	:	:	_	1	punct	_	_
13	a	a	DT	DT	_	15	det	_	_
14	B-cell-specific	b-cell-specific	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	1	dep	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	delayed	delay	VBN	VBN	_	15	acl:relcl	_	_
19	relative	relative	JJ	JJ	_	18	advmod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	to	to	TO	TO	_	26	case	_	_
26	induction	induction	NN	NN	_	23	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	surface	surface	NN	NN	_	30	compound	_	_
30	markers	marker	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	27	nsubjpass	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
6	virus	virus	NN	NN	_	9	compound	_	_
7	latent	latent	JJ	JJ	_	9	amod	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	2	nmod	_	_
10	LMP1	lmp1	NN	NN	_	9	dep	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	enhance	enhance	VB	VB	_	2	acl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	survival	survival	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	infected	infected	JJ	JJ	_	18	amod	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	through	through	IN	IN	_	20	case	_	_
20	upregulation	upregulation	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	bcl-2	bcl-2	NN	NN	_	24	compound	_	_
24	oncogene	oncogene	NN	NN	_	20	nmod	_	_
25	was	be	VBD	VBD	_	27	auxpass	_	_
26	first	first	RB	RB	_	27	advmod	_	_
27	suggested	suggest	VBN	VBN	_	0	root	_	_
28	by	by	IN	IN	_	29	case	_	_
29	experiments	experiment	NNS	NNS	_	27	nmod	_	_
30	involving	involve	VBG	VBG	_	29	acl	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	transfection	transfection	NN	NN	_	30	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	the	the	DT	DT	_	35	det	_	_
35	selection	selection	NN	NN	_	32	conj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	stable	stable	JJ	JJ	_	39	amod	_	_
38	LMP1+	lmp1+	JJ	JJ	_	39	amod	_	_
39	clones	clone	NNS	NNS	_	35	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	S.Henderson	S.Henderson	NNP	NNP	_	27	dep	_	_
42	,	,	,	,	_	41	punct	_	_
43	M.	M.	NNP	NNP	_	44	compound	_	_
44	Rowe	Rowe	NNP	NNP	_	41	conj	_	_
45	,	,	,	,	_	41	punct	_	_
46	C.Gregory	C.Gregory	NNP	NNP	_	41	conj	_	_
47	,	,	,	,	_	41	punct	_	_
48	F.Wang	F.Wang	NNP	NNP	_	41	conj	_	_
49	,	,	,	,	_	41	punct	_	_
50	E.Kieff	E.Kieff	NNP	NNP	_	41	conj	_	_
51	,	,	,	,	_	41	punct	_	_
52	and	and	CC	CC	_	41	cc	_	_
53	A.Rickinson	A.Rickinson	NNP	NNP	_	41	conj	_	_
54	,	,	,	,	_	41	punct	_	_
55	Cell	Cell	NNP	NNP	_	41	appos	_	_
56	65	65	CD	CD	_	55	nummod	_	_
57	:	:	:	:	_	41	punct	_	_
58	1107-1115	1107-1115	CD	CD	_	41	dep	_	_
59	,	,	,	,	_	41	punct	_	_
60	1991	1991	CD	CD	_	41	amod	_	_
61	)	)	-RRB-	-RRB-	_	41	punct	_	_
62	.	.	.	.	_	27	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	possible	possible	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	ascertain	ascertain	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	15	mark	_	_
10	Bcl-2	bcl-2	NN	NN	_	11	compound	_	_
11	upregulation	upregulation	NN	NN	_	15	nsubj	_	_
12	was	be	VBD	VBD	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	consequence	consequence	NN	NN	_	8	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	LMP1	lmp1	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	or	or	CC	CC	_	15	cc	_	_
20	an	a	DT	DT	_	21	det	_	_
21	artifact	artifact	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	selection	selection	NN	NN	_	25	compound	_	_
25	procedure	procedure	NN	NN	_	21	nmod	_	_
26	whereby	whereby	WRB	WRB	_	39	advmod	_	_
27	rare	rare	JJ	JJ	_	29	amod	_	_
28	Bcl-2+	bcl-2+	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	39	nsubj	_	_
30	already	already	RB	RB	_	29	advmod	_	_
31	present	present	JJ	JJ	_	29	amod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	starting	start	VBG	VBG	_	35	amod	_	_
35	population	population	NN	NN	_	31	nmod	_	_
36	might	might	MD	MD	_	39	aux	_	_
37	best	best	RBS	RBS	_	39	advmod	_	_
38	be	be	VB	VB	_	39	cop	_	_
39	able	able	JJ	JJ	_	25	acl:relcl	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	tolerate	tolerate	VB	VB	_	39	xcomp	_	_
42	the	the	DT	DT	_	45	det	_	_
43	potentially	potentially	RB	RB	_	45	advmod	_	_
44	toxic	toxic	JJ	JJ	_	45	amod	_	_
45	effects	effect	NNS	NNS	_	41	dobj	_	_
46	of	of	IN	IN	_	47	case	_	_
47	LMP1	lmp1	NN	NN	_	45	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	reexamined	reexamine	VBD	VBD	_	0	root	_	_
4	this	this	DT	DT	_	5	det	_	_
5	issue	issue	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	using	use	VBG	VBG	_	3	advcl	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	experimental	experimental	JJ	JJ	_	9	dep	_	_
11	approaches	approach	NNS	NNS	_	7	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	allowed	allow	VBD	VBD	_	11	acl:relcl	_	_
14	LMP1-induced	lmp1-induced	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	monitored	monitor	VBN	VBN	_	13	xcomp	_	_
19	immediately	immediately	RB	RB	_	18	advmod	_	_
20	following	follow	VBG	VBG	_	21	case	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	viral	viral	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	absence	absence	NN	NN	_	21	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	selective	selective	JJ	JJ	_	32	amod	_	_
32	pressures	pressure	NNS	NNS	_	29	nmod	_	_
33	;	;	:	:	_	3	punct	_	_
34	activation	activation	NN	NN	_	50	nsubjpass	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	34	nmod	_	_
39	transcription	transcription	NN	NN	_	40	compound	_	_
40	factor	factor	NN	NN	_	38	dep	_	_
41	and	and	CC	CC	_	34	cc	_	_
42	upregulation	upregulation	NN	NN	_	34	conj	_	_
43	of	of	IN	IN	_	47	case	_	_
44	the	the	DT	DT	_	47	det	_	_
45	cell	cell	NN	NN	_	47	compound	_	_
46	adhesion	adhesion	NN	NN	_	47	compound	_	_
47	molecule	molecule	NN	NN	_	42	nmod	_	_
48	ICAM-1	icam-1	NN	NN	_	47	dep	_	_
49	were	be	VBD	VBD	_	50	auxpass	_	_
50	used	use	VBN	VBN	_	3	parataxis	_	_
51	as	as	IN	IN	_	53	case	_	_
52	early	early	JJ	JJ	_	53	amod	_	_
53	indices	index	NNS	NNS	_	50	nmod	_	_
54	of	of	IN	IN	_	56	case	_	_
55	LMP1	lmp1	NN	NN	_	56	compound	_	_
56	function	function	NN	NN	_	53	nmod	_	_
57	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	approach	approach	NN	NN	_	25	nmod	_	_
5	,	,	,	,	_	25	punct	_	_
6	stable	stable	JJ	JJ	_	7	amod	_	_
7	clones	clone	NNS	NNS	_	25	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	7	nmod	_	_
12	carrying	carry	VBG	VBG	_	11	acl	_	_
13	an	a	DT	DT	_	15	det	_	_
14	LMP1	lmp1	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	12	dobj	_	_
16	under	under	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	control	control	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	inducible	inducible	JJ	JJ	_	23	amod	_	_
22	metallothionein	metallothionein	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	18	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	induced	induce	VBN	VBN	_	0	root	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	express	express	VB	VB	_	25	xcomp	_	_
28	LMP1	lmp1	NN	NN	_	27	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	all	all	DT	DT	_	31	det	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	25	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NK-kappa	nk-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	upregulation	upregulation	NN	NN	_	1	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ICAM-1	icam-1	NN	NN	_	6	nmod	_	_
9	occurred	occur	VBD	VBD	_	0	root	_	_
10	within	within	IN	IN	_	12	case	_	_
11	24	24	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	followed	follow	VBN	VBN	_	9	conj	_	_
16	at	at	IN	IN	_	20	case	_	_
17	48	48	CD	CD	_	19	compound	_	_
18	to	to	TO	TO	_	19	dep	_	_
19	72	72	CD	CD	_	20	nummod	_	_
20	h	h	NN	NN	_	15	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	upregulation	upregulation	NN	NN	_	15	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Bcl-2	bcl-2	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	second	second	JJ	JJ	_	4	amod	_	_
4	approach	approach	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	tested	test	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	generality	generality	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	phenomenon	phenomenon	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	15	mark	_	_
14	transiently	transiently	RB	RB	_	15	advmod	_	_
15	expressing	express	VBG	VBG	_	7	advcl	_	_
16	LMP1	lmp1	NN	NN	_	15	dobj	_	_
17	from	from	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	strong	strong	JJ	JJ	_	22	amod	_	_
20	constitutively	constitutively	RB	RB	_	19	advmod	_	_
21	active	active	JJ	JJ	_	19	dep	_	_
22	promoter	promoter	NN	NN	_	15	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	range	range	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	different	different	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	types	type	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	All	all	DT	DT	_	4	det	_	_
2	six	six	CD	CD	_	4	nummod	_	_
3	B-cell	b-cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	6	nsubj	_	_
5	tested	test	VBN	VBN	_	4	acl	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	response	response	NN	NN	_	6	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	LMP1	lmp1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	this	this	DT	DT	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	followed	follow	VBN	VBN	_	6	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	five	five	CD	CD	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	six	six	CD	CD	_	24	nummod	_	_
24	lines	line	NNS	NNS	_	21	nmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	expression	expression	NN	NN	_	19	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	ICAM-1	icam-1	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	Bcl-2	bcl-2	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	same	same	JJ	JJ	_	4	amod	_	_
4	experiments	experiment	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	all	all	DT	DT	_	9	det	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	non-B-cell	non-b-cell	JJ	JJ	_	9	amod	_	_
9	lines	line	NNS	NNS	_	10	nsubj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ICAM-1	icam-1	NN	NN	_	16	compound	_	_
16	upregulation	upregulation	NN	NN	_	13	conj	_	_
17	but	but	CC	CC	_	13	cc	_	_
18	never	never	RB	RB	_	20	advmod	_	_
19	any	any	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	13	conj	_	_
21	upon	upon	IN	IN	_	22	case	_	_
22	Bcl-2	bcl-2	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	Bcl-2	bcl-2	NN	NN	_	6	compound	_	_
6	upregulation	upregulation	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	part	part	NN	NN	_	3	ccomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	panoply	panoply	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	changes	change	NNS	NNS	_	11	nmod	_	_
15	induced	induce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	LMP1	lmp1	NN	NN	_	15	nmod	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	effect	effect	NN	NN	_	25	nsubj	_	_
22	is	be	VBZ	VBZ	_	25	cop	_	_
23	cell	cell	NN	NN	_	25	nmod:npmod	_	_
24	type	type	NN	NN	_	25	nmod:npmod	_	_
25	specific	specific	JJ	JJ	_	8	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	whilst	whilst	IN	IN	_	13	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	13	nsubj	_	_
9	may	may	MD	MD	_	13	aux	_	_
10	be	be	VB	VB	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	essential	essential	JJ	JJ	_	13	amod	_	_
13	component	component	NN	NN	_	24	advcl	_	_
14	of	of	IN	IN	_	17	case	_	_
15	LMP1	lmp1	NN	NN	_	17	compound	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	24	punct	_	_
19	other	other	JJ	JJ	_	21	amod	_	_
20	cell-specific	cell-specific	JJ	JJ	_	21	amod	_	_
21	factors	factor	NNS	NNS	_	24	nsubjpass	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	4	ccomp	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	effect	effect	VB	VB	_	24	xcomp	_	_
27	some	some	DT	DT	_	28	det	_	_
28	functions	function	NNS	NNS	_	26	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	viral	viral	JJ	JJ	_	32	amod	_	_
32	protein	protein	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Tat-binding	tat-binding	JJ	JJ	_	2	amod	_	_
2	protein	protein	NN	NN	_	6	nsubj	_	_
3	7	7	CD	CD	_	2	nummod	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subunit	subunit	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	26S	26s	NN	NN	_	10	compound	_	_
10	protease	protease	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Subunit	subunit	NN	NN	_	20	nsubjpass	_	_
2	6	6	CD	CD	_	1	nummod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	S6	s6	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	1	punct	_	_
7	an	a	DT	DT	_	9	det	_	_
8	integral	integral	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	1	appos	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	26S	26s	NN	NN	_	13	compound	_	_
13	protease	protease	NN	NN	_	9	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	erythrocytes	erythrocyte	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	studied	study	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	22	case	_	_
22	SDS-PAGE	sds-page	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	peptide	peptide	NN	NN	_	25	compound	_	_
25	mapping	mapping	NN	NN	_	22	conj	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	sequence	sequence	NN	NN	_	28	compound	_	_
28	analysis	analysis	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	20	punct	_	_

1	S6	s6	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	cleaved	cleave	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	CNBr	cnbr	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	internal	internal	JJ	JJ	_	9	amod	_	_
9	peptides	peptide	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	sequenced	sequence	VBN	VBN	_	3	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	comparison	comparison	NN	NN	_	8	nsubj	_	_
3	with	with	IN	IN	_	5	case	_	_
4	known	known	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	Genbank	Genbank	NNP	NNP	_	5	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	all	all	DT	DT	_	13	det	_	_
11	three	three	CD	CD	_	13	nummod	_	_
12	S6	s6	NN	NN	_	13	compound	_	_
13	peptides	peptide	NNS	NNS	_	14	nsubj	_	_
14	match	match	VBP	VBP	_	8	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	predicted	predict	VBN	VBN	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	TBP7	tbp7	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	Tat-binding	tat-binding	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	19	appos	_	_
23	7	7	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	peptide	peptide	NN	NN	_	4	compound	_	_
4	matches	match	NNS	NNS	_	36	advcl	_	_
5	covering	cover	VBG	VBG	_	4	acl	_	_
6	more	more	JJR	JJR	_	8	advmod	_	_
7	than	than	IN	IN	_	6	mwe	_	_
8	10	10	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	TBP7	tbp7	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	fact	fact	NN	NN	_	4	conj	_	_
18	that	that	IN	IN	_	26	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	migration	migration	NN	NN	_	26	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	S6	s6	NN	NN	_	20	nmod	_	_
23	on	on	IN	IN	_	24	case	_	_
24	SDS-PAGE	sds-page	NN	NN	_	20	nmod	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	consistent	consistent	JJ	JJ	_	17	ccomp	_	_
27	with	with	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	estimated	estimate	VBN	VBN	_	31	amod	_	_
30	molecular	molecular	JJ	JJ	_	31	amod	_	_
31	mass	mass	NN	NN	_	26	nmod	_	_
32	for	for	IN	IN	_	33	case	_	_
33	TBP7	tbp7	NN	NN	_	31	nmod	_	_
34	,	,	,	,	_	36	punct	_	_
35	we	we	PRP	PRP	_	36	nsubj	_	_
36	conclude	conclude	VBP	VBP	_	0	root	_	_
37	that	that	IN	IN	_	45	mark	_	_
38	subunit	subunit	NN	NN	_	45	nsubj	_	_
39	6	6	CD	CD	_	38	nummod	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	26S	26s	NN	NN	_	43	compound	_	_
43	protease	protease	NN	NN	_	38	nmod	_	_
44	is	be	VBZ	VBZ	_	45	cop	_	_
45	TBP7	tbp7	NN	NN	_	36	ccomp	_	_
46	.	.	.	.	_	36	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	8	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	replicative	replicative	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	tumour	tumour	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	AIDS-related	aids-related	JJ	JJ	_	16	amod	_	_
14	non-Hodgkin	non-hodgkin	JJ	JJ	_	16	amod	_	_
15	's	's	POS	POS	_	16	case	_	_
16	lymphoma	lymphoma	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	relation	relation	NN	NN	_	8	nmod	_	_
19	to	to	TO	TO	_	22	case	_	_
20	CD4	cd4	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	number	number	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	antibody	antibody	NN	NN	_	25	compound	_	_
25	titres	titre	NNS	NNS	_	22	conj	_	_
26	to	to	TO	TO	_	27	case	_	_
27	EBV	ebv	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	1	dep	_	_
5	whether	whether	IN	IN	_	26	mark	_	_
6	activation	activation	NN	NN	_	26	nsubjpass	_	_
7	of	of	IN	IN	_	13	case	_	_
8	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
9	virus	virus	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	EBV	ebv	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	replication	replication	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	tumour	tumour	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	6	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	AIDS-related	aids-related	JJ	JJ	_	21	amod	_	_
19	non-Hodgkin	non-hodgkin	JJ	JJ	_	21	amod	_	_
20	's	's	POS	POS	_	21	case	_	_
21	lymphoma	lymphoma	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	ARNHL	arnhl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	correlated	correlate	VBN	VBN	_	4	ccomp	_	_
27	with	with	IN	IN	_	30	case	_	_
28	CD4+	cd4+	JJ	JJ	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	counts	count	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	influences	influence	VBZ	VBZ	_	26	conj	_	_
33	antibody	antibody	NN	NN	_	34	compound	_	_
34	response	response	NN	NN	_	32	dobj	_	_
35	to	to	TO	TO	_	36	case	_	_
36	EBV	ebv	NN	NN	_	34	nmod	_	_
37	-LSB-	-lsb-	-LRB-	-LRB-	_	41	punct	_	_
38	anti-Z	anti-z	JJ	JJ	_	41	amod	_	_
39	Epstein-Barr	epstein-barr	JJ	JJ	_	41	amod	_	_
40	replicative	replicative	JJ	JJ	_	41	amod	_	_
41	activator	activator	NN	NN	_	4	dep	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	ZEBRA	zebra	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	41	punct	_	_
46	anti-early	anti-early	JJ	JJ	_	47	amod	_	_
47	antigen	antigen	NN	NN	_	41	appos	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	EA	ea	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	,	,	,	,	_	41	punct	_	_
52	anti-viral	anti-viral	JJ	JJ	_	54	amod	_	_
53	capsid	capsid	NN	NN	_	54	compound	_	_
54	antigen	antigen	NN	NN	_	41	appos	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	VCA	vca	NN	NN	_	54	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	-RSB-	-rsb-	-RRB-	-RRB-	_	41	punct	_	_
59	.	.	.	.	_	4	punct	_	_

1	DESIGN	design	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Retrospective	retrospective	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	1	dep	_	_
5	based	base	VBN	VBN	_	7	case	_	_
6	on	on	IN	IN	_	7	case	_	_
7	immunohistochemistry	immunohistochemistry	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	situ	situ	FW	FW	_	9	dep	_	_
11	hybridization	hybridization	NN	NN	_	4	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	detect	detect	VB	VB	_	11	acl	_	_
14	EBV	ebv	NN	NN	_	17	compound	_	_
15	replicative	replicative	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	products	product	NNS	NNS	_	13	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	tissue	tissue	NN	NN	_	20	compound	_	_
20	samples	sample	NNS	NNS	_	13	nmod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	patients	patient	NNS	NNS	_	20	nmod	_	_
23	affected	affect	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	ARNHL	arnhl	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	4	cc	_	_
27	correlation	correlation	NN	NN	_	4	conj	_	_
28	with	with	IN	IN	_	31	case	_	_
29	CD4+	cd4+	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	counts	count	NNS	NNS	_	27	nmod	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	results	result	NNS	NNS	_	27	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	EBV	ebv	NN	NN	_	36	compound	_	_
36	serology	serology	NN	NN	_	33	nmod	_	_
37	(	(	-LRB-	-LRB-	_	40	punct	_	_
38	including	include	VBG	VBG	_	40	case	_	_
39	anti-ZEBRA	anti-zebra	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	36	nmod	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	in	in	IN	IN	_	43	case	_	_
43	sera	serum	NNS	NNS	_	33	nmod	_	_
44	from	from	IN	IN	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	same	same	JJ	JJ	_	47	amod	_	_
47	patients	patient	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	4	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Seventeen	seventeen	CD	CD	_	6	compound	_	_
4	out	out	IN	IN	_	6	advmod	_	_
5	of	of	IN	IN	_	6	advmod	_	_
6	22	22	CD	CD	_	7	nummod	_	_
7	cases	case	NNS	NNS	_	11	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	ARNHL	arnhl	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	selected	select	VBN	VBN	_	1	dep	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	EBV	ebv	NN	NN	_	14	nmod	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	20	punct	_	_
18	Epstein-Barr	epstein-barr	JJ	JJ	_	20	amod	_	_
19	early	early	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	16	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	EBER	eber	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	RNA-positive	rna-positive	JJ	JJ	_	20	amod	_	_
25	-RSB-	-rsb-	-RRB-	-RRB-	_	20	punct	_	_
26	.	.	.	.	_	11	punct	_	_

1	Immunohistochemistry	immunohistochemistry	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	performed	perform	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	anti-ZEBRA	anti-zebra	JJ	JJ	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	anti-EA-restricted	anti-ea-restricted	JJ	JJ	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	anti-VCA	anti-vca	JJ	JJ	_	5	appos	_	_
10	antibodies	antibody	NNS	NNS	_	5	dep	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	in	in	FW	FW	_	14	amod	_	_
13	situ	situ	FW	FW	_	12	dep	_	_
14	hybridization	hybridization	NN	NN	_	5	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	BHLF1/NotI	bhlf1/noti	NN	NN	_	17	compound	_	_
17	oligoprobes	oligoprobe	NNS	NNS	_	14	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	tumour	tumour	NN	NN	_	20	compound	_	_
20	samples	sample	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Results	result	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	statistically	statistically	RB	RB	_	4	advmod	_	_
4	correlated	correlate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	those	those	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	CD4+	cd4+	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	counts	count	NNS	NNS	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	17	17	CD	CD	_	15	compound	_	_
13	out	out	IN	IN	_	15	advmod	_	_
14	of	of	IN	IN	_	15	advmod	_	_
15	17	17	CD	CD	_	10	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	with	with	IN	IN	_	21	case	_	_
19	anti-EBV	anti-ebv	JJ	JJ	_	21	amod	_	_
20	antibody	antibody	NN	NN	_	21	compound	_	_
21	titres	titre	NNS	NNS	_	6	conj	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	13	13	CD	CD	_	26	compound	_	_
24	out	out	IN	IN	_	26	advmod	_	_
25	of	of	IN	IN	_	26	advmod	_	_
26	17	17	CD	CD	_	21	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	assessed	assess	VBN	VBN	_	21	acl	_	_
29	using	use	VBG	VBG	_	28	xcomp	_	_
30	standard	standard	JJ	JJ	_	32	amod	_	_
31	immunofluorescence	immunofluorescence	NN	NN	_	32	compound	_	_
32	method	method	NN	NN	_	29	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	enzyme-linked	enzyme-linked	JJ	JJ	_	37	amod	_	_
35	immunosorbent	immunosorbent	JJ	JJ	_	34	dep	_	_
36	assay	assay	NN	NN	_	37	compound	_	_
37	procedure	procedure	NN	NN	_	32	conj	_	_
38	using	use	VBG	VBG	_	32	acl	_	_
39	recombinant	recombinant	JJ	JJ	_	41	amod	_	_
40	ZEBRA	zebra	NN	NN	_	41	compound	_	_
41	protein	protein	NN	NN	_	38	dobj	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	synthetic	synthetic	JJ	JJ	_	44	amod	_	_
44	peptides	peptide	NNS	NNS	_	41	conj	_	_
45	as	as	IN	IN	_	46	case	_	_
46	antigens	antigen	NNS	NNS	_	38	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	BZLF1	bzlf1	NN	NN	_	17	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ZEBRA	zebra	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	or	or	CC	CC	_	3	cc	_	_
8	early	early	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	products	product	NNS	NNS	_	3	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	EA-R	ea-r	NN	NN	_	10	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	EA-D/BHLF1/NotI	ea-d/bhlf1/noti	NN	NN	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	detected	detect	VBN	VBN	_	1	dep	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	small	small	JJ	JJ	_	21	amod	_	_
21	proportion	proportion	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	&lt;	&lt;	JJR	JJR	_	21	dep	_	_
24	0.01-5	0.01-5	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	23	dep	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	of	of	IN	IN	_	29	case	_	_
28	tumour	tumour	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	21	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	eight	eight	CD	CD	_	21	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	these	these	DT	DT	_	35	det	_	_
34	17	17	CD	CD	_	35	nummod	_	_
35	cases	case	NNS	NNS	_	31	nmod	_	_
36	by	by	IN	IN	_	37	case	_	_
37	immunohistochemistry	immunohistochemistry	NN	NN	_	17	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	in	in	FW	FW	_	41	amod	_	_
40	situ	situ	FW	FW	_	39	dep	_	_
41	hybridization	hybridization	NN	NN	_	37	conj	_	_
42	.	.	.	.	_	17	punct	_	_

1	Demonstration	demonstration	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	replicative	replicative	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	correlate	correlate	VB	VB	_	0	root	_	_
9	with	with	IN	IN	_	14	case	_	_
10	either	either	CC	CC	_	14	cc:preconj	_	_
11	low	low	JJ	JJ	_	14	amod	_	_
12	CD4+	cd4+	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	counts	count	NNS	NNS	_	8	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	P	p	NN	NN	_	14	dep	_	_
17	&gt;	&gt;	JJR	JJR	_	16	amod	_	_
18	0.05	0.05	CD	CD	_	17	dep	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	or	or	CC	CC	_	14	cc	_	_
21	anti-EBV	anti-ebv	JJ	JJ	_	23	amod	_	_
22	antibody	antibody	NN	NN	_	23	compound	_	_
23	titres	titre	NNS	NNS	_	14	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	P	p	NN	NN	_	23	dep	_	_
26	&gt;	&gt;	JJR	JJR	_	25	amod	_	_
27	0.05	0.05	CD	CD	_	26	dep	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	.	.	.	.	_	8	punct	_	_

1	Anti-ZEBRA	anti-zebra	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	6	nsubjpass	_	_
3	was	be	VBD	VBD	_	6	auxpass	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	increased	increase	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	affected	affect	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	ARNHL	arnhl	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	17	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	14	nmod	_	_
17	expressed	express	VBD	VBD	_	8	acl:relcl	_	_
18	replicative	replicative	JJ	JJ	_	20	amod	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	products	product	NNS	NNS	_	17	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	P	p	NN	NN	_	20	dep	_	_
23	&gt;	&gt;	JJR	JJR	_	22	amod	_	_
24	0.05	0.05	CD	CD	_	23	dep	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	.	.	.	.	_	6	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	degree	degree	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	4	nmod	_	_
7	does	do	VBZ	VBZ	_	10	aux	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	clearly	clearly	RB	RB	_	10	advmod	_	_
10	enhance	enhance	VB	VB	_	1	dep	_	_
11	replicative	replicative	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	tumour	tumour	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	ARNHL	arnhl	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	EBV	ebv	NN	NN	_	2	compound	_	_
2	serology	serology	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	including	include	VBG	VBG	_	6	case	_	_
5	anti-ZEBRA	anti-zebra	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	not	not	RB	RB	_	12	neg	_	_
10	a	a	DT	DT	_	12	det	_	_
11	reliable	reliable	JJ	JJ	_	12	amod	_	_
12	tool	tool	NN	NN	_	0	root	_	_
13	for	for	IN	IN	_	14	mark	_	_
14	predicting	predict	VBG	VBG	_	12	acl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	occurrence	occurrence	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	such	such	JJ	JJ	_	19	amod	_	_
19	proliferations	proliferation	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Solution	solution	NN	NN	_	2	compound	_	_
2	structure	structure	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	POU-specific	pou-specific	JJ	JJ	_	6	amod	_	_
6	homeodomain	homeodomain	NN	NN	_	2	nmod	_	_
7	:	:	:	:	_	2	punct	_	_
8	3D-NMR	3d-nmr	NN	NN	_	9	compound	_	_
9	studies	study	NNS	NNS	_	2	dep	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	B-cell	b-cell	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	9	nmod	_	_
15	Oct-2	oct-2	NN	NN	_	14	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	POU	pou	NN	NN	_	4	compound	_	_
3	DNA-binding	dna-binding	JJ	JJ	_	4	amod	_	_
4	motif	motif	NN	NN	_	5	nsubj	_	_
5	defines	define	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	conserved	conserve	VBN	VBN	_	8	amod	_	_
8	family	family	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	eukaryotic	eukaryotic	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	involved	involve	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	regulation	regulation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	bipartite	bipartite	JJ	JJ	_	3	amod	_	_
3	motif	motif	NN	NN	_	4	nsubj	_	_
4	consists	consist	VBZ	VBZ	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	N-terminal	n-terminal	JJ	JJ	_	9	amod	_	_
8	POU-specific	pou-specific	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	POUs	pous	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	flexible	flexible	JJ	JJ	_	16	amod	_	_
16	linker	linker	NN	NN	_	9	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	a	a	DT	DT	_	22	det	_	_
20	C-terminal	c-terminal	JJ	JJ	_	22	amod	_	_
21	POU-specific	pou-specific	JJ	JJ	_	22	amod	_	_
22	homeodomain	homeodomain	NN	NN	_	9	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	POUHD	pouhd	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	solution	solution	NN	NN	_	6	compound	_	_
6	structure	structure	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	POU-specific	pou-specific	JJ	JJ	_	10	amod	_	_
10	homeodomain	homeodomain	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	NMR	nmr	NN	NN	_	3	compound	_	_
3	model	model	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	obtained	obtain	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	Oct-2	oct-2	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	B-cell	b-cell	NN	NN	_	14	compound	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	7	appos	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	participates	participate	VBZ	VBZ	_	14	acl:relcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	immunoglobulin	immunoglobulin	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	fragment	fragment	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Oct-2	oct-2	NN	NN	_	2	nmod	_	_
5	containing	containing	NN	NN	_	4	dep	_	_
6	POUHD	pouhd	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	an	a	DT	DT	_	10	det	_	_
9	adjoining	adjoining	JJ	JJ	_	10	amod	_	_
10	linker	linker	NN	NN	_	6	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	Escherichia	escherichia	FW	FW	_	15	compound	_	_
15	coli	coli	FW	FW	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	characterized	characterize	VBN	VBN	_	12	conj	_	_
18	by	by	IN	IN	_	26	case	_	_
19	three-dimensional	three-dimensional	JJ	JJ	_	22	amod	_	_
20	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
21	magnetic	magnetic	JJ	JJ	_	22	amod	_	_
22	resonance	resonance	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	3D-NMR	3d-nmr	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	spectroscopy	spectroscopy	NN	NN	_	17	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Complete	complete	JJ	JJ	_	2	amod	_	_
2	1H	1h	NN	NN	_	12	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	15N	15n	NN	NN	_	2	conj	_	_
5	resonance	resonance	NN	NN	_	6	compound	_	_
6	assignment	assignment	NN	NN	_	2	dep	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	POUHD	pouhd	NN	NN	_	10	compound	_	_
10	moiety	moiety	NN	NN	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	presented	present	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	POUHD	pouhd	NN	NN	_	4	compound	_	_
3	solution	solution	NN	NN	_	4	compound	_	_
4	structure	structure	NN	NN	_	19	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	calculated	calculate	VBN	VBN	_	4	dep	_	_
8	by	by	IN	IN	_	10	case	_	_
9	distance	distance	NN	NN	_	10	compound	_	_
10	geometry	geometry	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	simulated	simulated	JJ	JJ	_	13	amod	_	_
13	annealing	annealing	NN	NN	_	10	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	DG/SA	dg/sa	NN	NN	_	10	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	4	punct	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	similar	similar	JJ	JJ	_	0	root	_	_
20	to	to	TO	TO	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	canonical	canonical	JJ	JJ	_	24	amod	_	_
24	homeodomains	homeodomain	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	salient	salient	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	10	nsubjpass	_	_
4	between	between	IN	IN	_	5	case	_	_
5	solution	solution	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	crystal	crystal	JJ	JJ	_	8	amod	_	_
8	structures	structure	NNS	NNS	_	5	conj	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	C-terminal	c-terminal	JJ	JJ	_	14	amod	_	_
14	segment	segment	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	alpha-helix	alpha-helix	JJ	JJ	_	17	amod	_	_
17	3	3	CD	CD	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	22	punct	_	_
19	the	the	DT	DT	_	22	det	_	_
20	HTH	hth	NN	NN	_	22	compound	_	_
21	recognition	recognition	NN	NN	_	22	compound	_	_
22	helix	helix	NN	NN	_	17	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	17	punct	_	_
25	which	which	WDT	WDT	_	29	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	29	auxpass	_	_
27	not	not	RB	RB	_	29	neg	_	_
28	well	well	RB	RB	_	29	advmod	_	_
29	ordered	order	VBN	VBN	_	17	acl:relcl	_	_
30	in	in	IN	IN	_	31	case	_	_
31	solution	solution	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	this	this	DT	DT	_	3	det	_	_
3	segment	segment	NN	NN	_	5	nsubj	_	_
4	presumably	presumably	RB	RB	_	5	advmod	_	_
5	folds	fold	VBZ	VBZ	_	16	advcl	_	_
6	upon	upon	IN	IN	_	9	case	_	_
7	specific	specific	JJ	JJ	_	9	amod	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	flexibility	flexibility	NN	NN	_	16	nsubj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	solution	solution	NN	NN	_	12	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	reduce	reduce	VB	VB	_	0	root	_	_
17	the	the	DT	DT	_	20	det	_	_
18	intrinsic	intrinsic	JJ	JJ	_	20	amod	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	affinity	affinity	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	POUHD	pouhd	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	absence	absence	NN	NN	_	16	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	POUs	pous	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	Superantigens	superantigen	NNS	NNS	_	2	nsubj	_	_
2	activate	activate	VBP	VBP	_	0	root	_	_
3	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Binding	binding	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	superantigens	superantigen	NNS	NNS	_	1	nmod	_	_
4	to	to	TO	TO	_	8	case	_	_
5	MHC	mhc	NN	NN	_	8	compound	_	_
6	class	class	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	molecules	molecule	NNS	NNS	_	1	nmod	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	transduction	transduction	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	biochemical	biochemical	JJ	JJ	_	14	amod	_	_
14	signals	signal	NNS	NNS	_	11	nmod	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	21	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	staphylococcal	staphylococcal	JJ	JJ	_	6	amod	_	_
6	superantigens	superantigen	NNS	NNS	_	21	nsubj	_	_
7	toxic	toxic	JJ	JJ	_	10	amod	_	_
8	shock	shock	NN	NN	_	10	compound	_	_
9	syndrome	syndrome	NN	NN	_	10	compound	_	_
10	toxin-1	toxin-1	NN	NN	_	6	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TSST-1	tsst-1	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	staphylococcal	staphylococcal	JJ	JJ	_	17	amod	_	_
16	enterotoxin	enterotoxin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SEA	sea	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	activate	activate	VBP	VBP	_	2	ccomp	_	_
22	HIV-1-LTR-driven	hiv-1-ltr-driven	JJ	JJ	_	23	amod	_	_
23	transcription	transcription	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	chloramphenicol	chloramphenicol	NN	NN	_	27	compound	_	_
26	acetyl	acetyl	NN	NN	_	27	compound	_	_
27	transferase	transferase	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	human	human	JJ	JJ	_	33	amod	_	_
31	monocytic	monocytic	JJ	JJ	_	33	amod	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	line	line	NN	NN	_	23	nmod	_	_
34	THP-1	thp-1	NN	NN	_	33	dep	_	_
35	.	.	.	.	_	2	punct	_	_

1	Induction	induction	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HIV-1-LTR-driven	hiv-1-ltr-driven	JJ	JJ	_	4	amod	_	_
4	transcription	transcription	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	THP-1	thp-1	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	superantigens	superantigen	NNS	NNS	_	1	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
17	factor-kappa	factor-kappa	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Superantigens	superantigen	NNS	NNS	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	viral	viral	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	secretion	secretion	NN	NN	_	3	dobj	_	_
7	from	from	IN	IN	_	18	case	_	_
8	the	the	DT	DT	_	18	det	_	_
9	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	18	amod	_	_
10	colony-stimulating	colony-stimulating	JJ	JJ	_	18	amod	_	_
11	factor-pretreated	factor-pretreated	JJ	JJ	_	18	amod	_	_
12	chronically	chronically	RB	RB	_	18	advmod	_	_
13	infected	infected	JJ	JJ	_	18	amod	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	line	line	NN	NN	_	18	compound	_	_
18	U1	u1	NN	NN	_	6	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	superantigens	superantigen	NNS	NNS	_	1	nmod	_	_
11	occurred	occur	VBD	VBD	_	0	root	_	_
12	via	via	IN	IN	_	14	case	_	_
13	tumor	tumor	NN	NN	_	14	compound	_	_
14	necrosis	necrosis	NN	NN	_	11	nmod	_	_
15	factor-alpha-dependent	factor-alpha-dependent	JJ	JJ	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	-independent	-independent	JJ	JJ	_	14	conj	_	_
18	mechanisms	mechanism	NNS	NNS	_	14	dep	_	_
19	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	superantigens	superantigen	NNS	NNS	_	13	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	other	other	JJ	JJ	_	11	amod	_	_
8	MHC	mhc	NN	NN	_	11	compound	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	ligands	ligand	NNS	NNS	_	5	conj	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	activate	activate	VB	VB	_	3	ccomp	_	_
14	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Leiomyosarcoma	leiomyosarcoma	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	vulva	vulva	NN	NN	_	1	nmod	_	_
5	:	:	:	:	_	1	punct	_	_
6	report	report	NN	NN	_	1	dep	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	case	case	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	52-year-old	52-year-old	JJ	JJ	_	3	amod	_	_
3	female	female	JJ	JJ	_	4	nsubj	_	_
4	presented	present	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	progressively	progressively	RB	RB	_	8	advmod	_	_
8	enlarging	enlarge	VBG	VBG	_	10	amod	_	_
9	vulvar	vulvar	JJ	JJ	_	10	amod	_	_
10	mass	mass	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Pathological	pathological	JJ	JJ	_	2	amod	_	_
2	evaluation	evaluation	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	high-grade	high-grade	JJ	JJ	_	7	amod	_	_
6	vulvar	vulvar	JJ	JJ	_	7	amod	_	_
7	leiomyosarcoma	leiomyosarcoma	NN	NN	_	3	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	ultrastructural	ultrastructural	JJ	JJ	_	1	conj	_	_
4	studies	study	NNS	NNS	_	1	dep	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	performed	perform	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	support	support	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	diagnosis	diagnosis	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	effort	effort	NN	NN	_	44	nmod	_	_
4	to	to	TO	TO	_	5	case	_	_
5	better	better	RBR	RBR	_	3	nmod	_	_
6	understand	understand	VB	VB	_	5	dep	_	_
7	the	the	DT	DT	_	8	det	_	_
8	biology	biology	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	tumor	tumor	NN	NN	_	8	nmod	_	_
12	additional	additional	JJ	JJ	_	14	amod	_	_
13	immunohistochemical	immunohistochemical	JJ	JJ	_	12	dep	_	_
14	studies	study	NNS	NNS	_	44	nsubjpass	_	_
15	for	for	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	product	product	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	p53	p53	NN	NN	_	23	compound	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	suppressor	suppressor	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	estrogen	estrogen	NN	NN	_	27	compound	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	18	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	tumor	tumor	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	,	,	,	,	_	18	punct	_	_
32	as	as	RB	RB	_	18	cc	_	_
33	well	well	RB	RB	_	32	mwe	_	_
34	as	as	IN	IN	_	32	mwe	_	_
35	the	the	DT	DT	_	36	det	_	_
36	type	type	NN	NN	_	18	conj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	immune	immune	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	infiltrating	infiltrate	VBG	VBG	_	39	acl	_	_
41	the	the	DT	DT	_	42	det	_	_
42	tumor	tumor	NN	NN	_	40	dobj	_	_
43	were	be	VBD	VBD	_	44	auxpass	_	_
44	performed	perform	VBN	VBN	_	0	root	_	_
45	.	.	.	.	_	44	punct	_	_

1	Tumor	tumor	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	overexpression	overexpression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	p53	p53	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	estrogen	estrogen	NN	NN	_	12	nmod:npmod	_	_
12	receptor-positive	receptor-positive	JJ	JJ	_	3	conj	_	_
13	.	.	.	.	_	3	punct	_	_

1	Macrophages	macrophage	NNS	NNS	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	T	t	NN	NN	_	1	conj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	B	b	NN	NN	_	3	conj	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	dep	_	_
7	infiltrated	infiltrate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	tumor	tumor	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	moderate	moderate	JJ	JJ	_	12	amod	_	_
12	numbers	number	NNS	NNS	_	7	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	occasional	occasional	JJ	JJ	_	17	amod	_	_
15	lymphoid	lymphoid	JJ	JJ	_	14	dep	_	_
16	aggregate	aggregate	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	7	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	attempt	attempt	NN	NN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	better	better	RBR	RBR	_	9	advmod	_	_
9	understand	understand	VB	VB	_	6	acl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	biology	biology	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	tumors	tumor	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	DNA-binding	dna-binding	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	transcriptional	transcriptional	JJ	JJ	_	1	conj	_	_
4	regulatory	regulatory	JJ	JJ	_	3	dep	_	_
5	properties	property	NNS	NNS	_	1	dep	_	_
6	of	of	IN	IN	_	9	case	_	_
7	hepatic	hepatic	JJ	JJ	_	9	amod	_	_
8	leukemia	leukemia	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HLF	hlf	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	1	cc	_	_
14	the	the	DT	DT	_	19	det	_	_
15	t(17;19)	t(17;19)	NN	NN	_	19	compound	_	_
16	acute	acute	JJ	JJ	_	19	amod	_	_
17	lymphoblastic	lymphoblastic	JJ	JJ	_	19	amod	_	_
18	leukemia	leukemia	NN	NN	_	19	compound	_	_
19	chimera	chimera	NN	NN	_	1	conj	_	_
20	E2A-HLF	e2a-hlf	JJ	JJ	_	19	amod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	t(17;19)	t(17;19)	NN	NN	_	3	compound	_	_
3	translocation	translocation	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	acute	acute	JJ	JJ	_	7	amod	_	_
6	lymphoblastic	lymphoblastic	JJ	JJ	_	7	amod	_	_
7	leukemias	leukemia	NNS	NNS	_	3	nmod	_	_
8	results	result	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	creation	creation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	19	case	_	_
12	E2A-hepatic	e2a-hepatic	JJ	JJ	_	14	amod	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HLF	hlf	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	chimeric	chimeric	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	10	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	contain	contain	VBP	VBP	_	19	acl:relcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	DNA-binding	dna-binding	JJ	JJ	_	21	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	protein	protein	NN	NN	_	27	compound	_	_
26	dimerization	dimerization	NN	NN	_	27	compound	_	_
27	domains	domain	NNS	NNS	_	23	conj	_	_
28	of	of	IN	IN	_	36	case	_	_
29	the	the	DT	DT	_	36	det	_	_
30	basic	basic	JJ	JJ	_	36	amod	_	_
31	leucine	leucine	NN	NN	_	36	compound	_	_
32	zipper	zipper	NN	NN	_	36	compound	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	bZIP	bzip	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	protein	protein	NN	NN	_	23	nmod	_	_
37	HLF	hlf	NN	NN	_	36	dep	_	_
38	fused	fuse	VBN	VBN	_	36	acl	_	_
39	to	to	TO	TO	_	41	case	_	_
40	a	a	DT	DT	_	41	det	_	_
41	portion	portion	NN	NN	_	38	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	E2A	e2a	NN	NN	_	44	compound	_	_
44	proteins	protein	NNS	NNS	_	41	nmod	_	_
45	with	with	IN	IN	_	48	case	_	_
46	transcriptional	transcriptional	JJ	JJ	_	48	amod	_	_
47	activation	activation	NN	NN	_	48	compound	_	_
48	properties	property	NNS	NNS	_	38	nmod	_	_
49	.	.	.	.	_	8	punct	_	_

1	An	a	DT	DT	_	7	det	_	_
2	in	in	FW	FW	_	7	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	binding	bind	VBG	VBG	_	7	amod	_	_
5	site	site	NN	NN	_	7	compound	_	_
6	selection	selection	NN	NN	_	7	compound	_	_
7	procedure	procedure	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	determine	determine	VB	VB	_	9	xcomp	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	sequences	sequence	NNS	NNS	_	11	dobj	_	_
14	preferentially	preferentially	RB	RB	_	15	advmod	_	_
15	bound	bind	VBN	VBN	_	13	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	wild-type	wild-type	JJ	JJ	_	18	amod	_	_
18	HLF	hlf	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	chimeric	chimeric	JJ	JJ	_	22	amod	_	_
21	E2A-HLF	e2a-hlf	JJ	JJ	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	18	conj	_	_
23	isolated	isolate	VBN	VBN	_	18	acl	_	_
24	from	from	IN	IN	_	27	case	_	_
25	various	various	JJ	JJ	_	27	amod	_	_
26	t(17;19)-bearing	t(17;19)-bearing	JJ	JJ	_	27	amod	_	_
27	leukemias	leukemia	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	All	all	DT	DT	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	selectively	selectively	RB	RB	_	6	advmod	_	_
6	bind	bind	VB	VB	_	3	xcomp	_	_
7	the	the	DT	DT	_	10	det	_	_
8	consensus	consensus	NN	NN	_	10	compound	_	_
9	sequence	sequence	NN	NN	_	10	compound	_	_
10	5'-GTTACGTAAT-3'	5'-gttacgtaat-3'	NN	NN	_	6	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	high	high	JJ	JJ	_	13	amod	_	_
13	affinity	affinity	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Wild-type	wild-type	JJ	JJ	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	chimeric	chimeric	JJ	JJ	_	5	amod	_	_
4	HLF	hlf	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	1	conj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	bound	bind	VBD	VBD	_	0	root	_	_
8	closely	closely	RB	RB	_	7	advmod	_	_
9	related	related	JJ	JJ	_	10	amod	_	_
10	sites	site	NNS	NNS	_	7	dobj	_	_
11	identified	identify	VBN	VBN	_	10	acl	_	_
12	previously	previously	RB	RB	_	11	advmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	bZIP	bzip	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	proline-	proline-	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	acidic	acidic	JJ	JJ	_	22	amod	_	_
22	amino	amino	NN	NN	_	19	conj	_	_
23	acid-rich	acid-rich	JJ	JJ	_	22	amod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PAR	par	NN	NN	_	19	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	C/EBP	c/ebp	NN	NN	_	19	conj	_	_
29	subfamilies	subfamily	NNS	NNS	_	19	dep	_	_
30	;	;	:	:	_	7	punct	_	_
31	however	however	RB	RB	_	38	advmod	_	_
32	,	,	,	,	_	38	punct	_	_
33	E2A-HLF	e2a-hlf	JJ	JJ	_	34	amod	_	_
34	proteins	protein	NNS	NNS	_	38	nsubj	_	_
35	were	be	VBD	VBD	_	38	cop	_	_
36	significantly	significantly	RB	RB	_	37	advmod	_	_
37	less	less	JJR	JJR	_	38	advmod	_	_
38	tolerant	tolerant	JJ	JJ	_	7	parataxis	_	_
39	of	of	IN	IN	_	41	case	_	_
40	certain	certain	JJ	JJ	_	41	amod	_	_
41	deviations	deviation	NNS	NNS	_	38	nmod	_	_
42	from	from	IN	IN	_	47	case	_	_
43	the	the	DT	DT	_	47	det	_	_
44	HLF	hlf	NN	NN	_	47	compound	_	_
45	consensus	consensus	NN	NN	_	47	compound	_	_
46	binding	binding	NN	NN	_	47	compound	_	_
47	site	site	NN	NN	_	41	nmod	_	_
48	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	5	nsubj	_	_
3	were	be	VBD	VBD	_	5	cop	_	_
4	directly	directly	RB	RB	_	5	advmod	_	_
5	attributable	attributable	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	loss	loss	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	an	a	DT	DT	_	13	det	_	_
10	HLF	hlf	NN	NN	_	13	compound	_	_
11	ancillary	ancillary	NN	NN	_	13	compound	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	domain	domain	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	all	all	DT	DT	_	17	det	_	_
16	E2A-HLF	e2a-hlf	JJ	JJ	_	17	amod	_	_
17	chimeras	chimera	NNS	NNS	_	7	nmod	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	were	be	VBD	VBD	_	21	cop	_	_
20	further	further	RB	RB	_	21	advmod	_	_
21	exacerbated	exacerbated	JJ	JJ	_	5	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	zipper	zipper	NN	NN	_	25	compound	_	_
25	mutation	mutation	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	one	one	CD	CD	_	28	nummod	_	_
28	isolate	isolate	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	wild-type	wild-type	JJ	JJ	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	chimeric	chimeric	JJ	JJ	_	6	amod	_	_
5	HLF	hlf	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	conj	_	_
7	displayed	display	VBD	VBD	_	0	root	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	activator	activator	NN	NN	_	10	compound	_	_
10	properties	property	NNS	NNS	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphoid	lymphoid	JJ	JJ	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	nonlymphoid	nonlymphoid	JJ	JJ	_	12	conj	_	_
15	cells	cell	NNS	NNS	_	12	dep	_	_
16	on	on	IN	IN	_	18	case	_	_
17	reporter	reporter	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	12	nmod	_	_
19	containing	contain	VBG	VBG	_	18	acl	_	_
20	HLF	hlf	NN	NN	_	19	dobj	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	C/EBP	c/ebp	NN	NN	_	20	conj	_	_
23	consensus	consensus	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	sites	site	NNS	NNS	_	20	dep	_	_
26	.	.	.	.	_	7	punct	_	_

1	But	but	CC	CC	_	13	cc	_	_
2	on	on	IN	IN	_	4	case	_	_
3	reporter	reporter	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	13	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	nonoptimal	nonoptimal	JJ	JJ	_	8	amod	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	sites	site	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	properties	property	NNS	NNS	_	13	nsubj	_	_
13	diverged	diverge	VBD	VBD	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	E2A-HLF	e2a-hlf	JJ	JJ	_	17	nsubj	_	_
16	competitively	competitively	RB	RB	_	17	advmod	_	_
17	inhibited	inhibit	VBD	VBD	_	13	conj	_	_
18	activation	activation	NN	NN	_	17	dobj	_	_
19	by	by	IN	IN	_	22	case	_	_
20	wild-type	wild-type	JJ	JJ	_	22	amod	_	_
21	PAR	par	NN	NN	_	22	compound	_	_
22	proteins	protein	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	spectrum	spectrum	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	binding	bind	VBG	VBG	_	10	amod	_	_
8	site-specific	site-specific	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	8	dep	_	_
10	properties	property	NNS	NNS	_	5	nmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	E2A-HLF	e2a-hlf	JJ	JJ	_	10	nmod	_	_
13	which	which	WDT	WDT	_	16	nsubj	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	preferentially	preferentially	RB	RB	_	16	advmod	_	_
16	activate	activate	VB	VB	_	12	acl:relcl	_	_
17	expression	expression	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	select	select	JJ	JJ	_	21	amod	_	_
20	subordinate	subordinate	JJ	JJ	_	19	dep	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	as	as	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	homodimer	homodimer	NN	NN	_	16	nmod	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	potentially	potentially	RB	RB	_	27	advmod	_	_
27	antagonize	antagonize	VB	VB	_	16	conj	_	_
28	expression	expression	NN	NN	_	27	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	others	other	NNS	NNS	_	28	nmod	_	_
31	through	through	IN	IN	_	33	case	_	_
32	heteromeric	heteromeric	JJ	JJ	_	33	amod	_	_
33	interactions	interaction	NNS	NNS	_	27	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Displacement	displacement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	E-box-binding	e-box-binding	JJ	JJ	_	5	amod	_	_
5	repressor	repressor	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	basic	basic	JJ	JJ	_	9	amod	_	_
8	helix-loop-helix	helix-loop-helix	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	1	nmod	_	_
10	:	:	:	:	_	1	punct	_	_
11	implications	implication	NNS	NNS	_	1	dep	_	_
12	for	for	IN	IN	_	14	case	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	specificity	specificity	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	immunoglobulin	immunoglobulin	NN	NN	_	19	compound	_	_
18	heavy-chain	heavy-chain	JJ	JJ	_	19	amod	_	_
19	enhancer	enhancer	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	immunoglobulin	immunoglobulin	NN	NN	_	10	compound	_	_
6	heavy-chain	heavy-chain	JJ	JJ	_	10	amod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	IgH	igh	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	enhancer	enhancer	NN	NN	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	restricted	restrict	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	although	although	IN	IN	_	19	mark	_	_
18	it	it	PRP	PRP	_	19	nsubj	_	_
19	binds	bind	VBZ	VBZ	_	12	advcl	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	B-cell-restricted	b-cell-restricted	JJ	JJ	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	ubiquitous	ubiquitous	JJ	JJ	_	21	conj	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	dep	_	_
26	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	enhancer	enhancer	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	non-B	non-b	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	upon	upon	IN	IN	_	9	case	_	_
9	overexpression	overexpression	NN	NN	_	1	nmod	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	basic	basic	JJ	JJ	_	17	amod	_	_
13	helix-loop-helix	helix-loop-helix	JJ	JJ	_	17	amod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	bHLH	bhlh	JJ	JJ	_	17	amod	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	protein	protein	NN	NN	_	9	nmod	_	_
18	E2A	e2a	NN	NN	_	17	dep	_	_
19	appears	appear	VBZ	VBZ	_	0	root	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	mediated	mediate	VBN	VBN	_	19	xcomp	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	only	only	RB	RB	_	27	cc:preconj	_	_
25	by	by	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	binding	binding	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	E2A	e2a	NN	NN	_	27	nmod	_	_
30	to	to	TO	TO	_	34	case	_	_
31	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
32	cognate	cognate	JJ	JJ	_	34	amod	_	_
33	E	e	NN	NN	_	34	compound	_	_
34	box	box	NN	NN	_	27	nmod	_	_
35	but	but	CC	CC	_	27	cc	_	_
36	also	also	RB	RB	_	40	advmod	_	_
37	by	by	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	resulting	result	VBG	VBG	_	40	amod	_	_
40	displacement	displacement	NN	NN	_	27	conj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	a	a	DT	DT	_	43	det	_	_
43	repressor	repressor	NN	NN	_	40	nmod	_	_
44	from	from	IN	IN	_	47	case	_	_
45	that	that	DT	DT	_	47	det	_	_
46	same	same	JJ	JJ	_	47	amod	_	_
47	site	site	NN	NN	_	40	nmod	_	_
48	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	9	det	_	_
5	``	``	``	``	_	9	punct	_	_
6	two-handed	two-handed	JJ	JJ	_	9	amod	_	_
7	zinc	zinc	NN	NN	_	9	compound	_	_
8	finger	finger	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	3	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	denoted	denote	VBN	VBN	_	9	acl	_	_
12	ZEB	zeb	NN	NN	_	11	xcomp	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	specificity	specificity	NN	NN	_	12	appos	_	_
17	of	of	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	19	nmod	_	_
19	mimics	mimic	VBZ	VBZ	_	16	acl:relcl	_	_
20	that	that	DT	DT	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cellular	cellular	JJ	JJ	_	24	amod	_	_
24	repressor	repressor	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	employing	employ	VBG	VBG	_	16	advcl	_	_
3	a	a	DT	DT	_	6	det	_	_
4	derivative	derivative	JJ	JJ	_	6	amod	_	_
5	E	e	NN	NN	_	6	compound	_	_
6	box	box	NN	NN	_	2	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	binds	bind	VBZ	VBZ	_	6	acl:relcl	_	_
9	ZEB	zeb	NN	NN	_	8	dobj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	E2A	e2a	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	have	have	VBP	VBP	_	16	aux	_	_
16	shown	show	VBN	VBN	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	repressor	repressor	NN	NN	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	active	active	JJ	JJ	_	16	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	IgH	igh	NN	NN	_	28	compound	_	_
28	enhancer	enhancer	NN	NN	_	30	nsubjpass	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	silenced	silence	VBN	VBN	_	21	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	absence	absence	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	competition	competition	NN	NN	_	33	nmod	_	_
37	by	by	IN	IN	_	39	case	_	_
38	bHLH	bhlh	JJ	JJ	_	39	amod	_	_
39	proteins	protein	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	16	punct	_	_

1	Hence	hence	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	propose	propose	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	necessary	necessary	JJ	JJ	_	8	amod	_	_
8	prerequisite	prerequisite	NN	NN	_	15	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	the	the	DT	DT	_	15	det	_	_
14	B-cell-specific	b-cell-specific	JJ	JJ	_	15	amod	_	_
15	displacement	displacement	NN	NN	_	4	ccomp	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	ZEB-like	zeb-like	JJ	JJ	_	19	amod	_	_
19	repressor	repressor	NN	NN	_	15	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	bHLH	bhlh	JJ	JJ	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	activation	activation	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	AP-1	ap-1	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	CD28	cd28	NN	NN	_	10	compound	_	_
10	signalling	signalling	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Co-stimulation	co-stimulation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	T-lymphocytes	t-lymphocyte	NNS	NNS	_	1	nmod	_	_
4	by	by	IN	IN	_	10	case	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TcR	tcr	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	occupancy	occupancy	NN	NN	_	1	nmod	_	_
11	and	and	CC	CC	_	1	cc	_	_
12	activation	activation	NN	NN	_	1	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CD28	cd28	NN	NN	_	17	compound	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	molecule	molecule	NN	NN	_	12	nmod	_	_
18	results	result	VBZ	VBZ	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	enhanced	enhance	VBN	VBN	_	21	amod	_	_
21	proliferation	proliferation	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	interleukin	interleukin	NN	NN	_	28	compound	_	_
24	2	2	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	IL-2	il-2	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	production	production	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	10	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	IL-2	il-2	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	triggered	trigger	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	CD28	cd28	NN	NN	_	7	nmod	_	_
10	involves	involve	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B-like	b-like	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	5'-regulatory	5'-regulatory	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	called	call	VBN	VBN	_	22	acl	_	_
25	CD28-responsive	cd28-responsive	JJ	JJ	_	26	amod	_	_
26	element	element	NN	NN	_	24	xcomp	_	_
27	.	.	.	.	_	10	punct	_	_

1	Stimulation	stimulation	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	T-cells	t-cell	NNS	NNS	_	1	nmod	_	_
4	by	by	IN	IN	_	7	case	_	_
5	agonistic	agonistic	JJ	JJ	_	7	amod	_	_
6	anti-CD28	anti-cd28	JJ	JJ	_	7	amod	_	_
7	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	conjunction	conjunction	NN	NN	_	1	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	phorbol	phorbol	NN	NN	_	13	compound	_	_
12	12-myristate	12-myristate	NN	NN	_	13	compound	_	_
13	13-acetate	13-acetate	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PMA	pma	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-	-	:	:	_	13	punct	_	_
18	or	or	CC	CC	_	13	cc	_	_
19	TcR-derived	tcr-derived	JJ	JJ	_	13	conj	_	_
20	signals	signal	NNS	NNS	_	13	dep	_	_
21	induces	induce	VBZ	VBZ	_	0	root	_	_
22	the	the	DT	DT	_	24	det	_	_
23	enhanced	enhance	VBN	VBN	_	24	amod	_	_
24	activation	activation	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	24	nmod	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	28	dep	_	_
31	.	.	.	.	_	21	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	CD28	cd28	NN	NN	_	6	compound	_	_
6	engagement	engagement	NN	NN	_	10	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	however	however	RB	RB	_	10	advmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	exerts	exert	VBZ	VBZ	_	3	ccomp	_	_
11	opposite	opposite	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	10	dobj	_	_
13	on	on	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	AP-1	ap-1	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	anti-CD28	anti-cd28	NN	NN	_	6	nsubj	_	_
3	together	together	RB	RB	_	6	advmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	PMA	pma	NN	NN	_	6	nmod	_	_
6	increased	increase	VBD	VBD	_	23	advcl	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	trans-activation	trans-activation	NN	NN	_	9	conj	_	_
12	activity	activity	NN	NN	_	9	dep	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	23	punct	_	_
17	PMA-induced	pma-induced	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	23	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	AP-1	ap-1	NN	NN	_	18	nmod	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	suppressed	suppress	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	8	nsubjpass	_	_
4	exerted	exert	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	anti-CD28	anti-cd28	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	level	level	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	11	nmod	_	_
15	as	as	RB	RB	_	11	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	in	in	IN	IN	_	21	case	_	_
19	functional	functional	JJ	JJ	_	21	amod	_	_
20	reporter-gene	reporter-gene	JJ	JJ	_	19	dep	_	_
21	assays	assay	NNS	NNS	_	11	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	two	two	CD	CD	_	8	nummod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	independently	independently	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	perform	perform	VB	VB	_	11	conj	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	functions	function	NNS	NNS	_	14	dobj	_	_
17	during	during	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Appraisal	appraisal	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	potential	potential	JJ	JJ	_	5	amod	_	_
4	therapeutic	therapeutic	JJ	JJ	_	3	dep	_	_
5	index	index	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	antioxidants	antioxidant	NNS	NNS	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	basis	basis	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
13	in	in	FW	FW	_	15	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	effects	effect	NNS	NNS	_	10	nmod	_	_
16	on	on	IN	IN	_	18	case	_	_
17	HIV	hiv	NN	NN	_	18	compound	_	_
18	replication	replication	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	interleukin	interleukin	NN	NN	_	25	compound	_	_
23	2-induced	2-induced	JJ	JJ	_	25	amod	_	_
24	lymphocyte	lymphocyte	NN	NN	_	25	compound	_	_
25	proliferation	proliferation	NN	NN	_	18	conj	_	_
26	.	.	.	.	_	1	punct	_	_

1	Antioxidant	antioxidant	JJ	JJ	_	2	amod	_	_
2	molecules	molecule	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	suggested	suggest	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	of	of	IN	IN	_	10	case	_	_
9	therapeutic	therapeutic	JJ	JJ	_	10	amod	_	_
10	value	value	NN	NN	_	5	xcomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	treatment	treatment	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HIV-infected	hiv-infected	JJ	JJ	_	16	amod	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	possibility	possibility	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	2	parataxis	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	7	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effects	effect	NNS	NNS	_	7	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	types	type	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	antioxidant	antioxidant	JJ	JJ	_	17	amod	_	_
17	molecules	molecule	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	terms	term	NNS	NNS	_	7	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	inhibition	inhibition	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	HIV	hiv	NN	NN	_	24	compound	_	_
24	replication	replication	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	one	one	CD	CD	_	26	appos	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	main	main	JJ	JJ	_	32	amod	_	_
32	reservoirs	reservoir	NNS	NNS	_	28	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	HIV	hiv	NN	NN	_	32	nmod	_	_
35	,	,	,	,	_	19	punct	_	_
36	and	and	CC	CC	_	19	cc	_	_
37	also	also	RB	RB	_	39	advmod	_	_
38	in	in	IN	IN	_	39	case	_	_
39	terms	term	NNS	NNS	_	19	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	modulation	modulation	NN	NN	_	39	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	immune	immune	JJ	JJ	_	45	amod	_	_
45	competence	competence	NN	NN	_	41	nmod	_	_
46	as	as	IN	IN	_	47	mark	_	_
47	measured	measure	VBN	VBN	_	45	dep	_	_
48	by	by	IN	IN	_	50	case	_	_
49	PBMC	pbmc	NN	NN	_	50	compound	_	_
50	proliferation	proliferation	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	tested	test	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	BHA	bha	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	14	det	_	_
9	phenolic	phenolic	JJ	JJ	_	14	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	lipid-soluble	lipid-soluble	JJ	JJ	_	9	dep	_	_
12	,	,	,	,	_	9	punct	_	_
13	chain-breaking	chain-breaking	JJ	JJ	_	9	dep	_	_
14	antioxidant	antioxidant	NN	NN	_	6	appos	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	NAC	nac	NN	NN	_	6	conj	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	22	det	_	_
20	known	known	JJ	JJ	_	22	amod	_	_
21	glutathione	glutathione	NN	NN	_	22	compound	_	_
22	precursor	precursor	NN	NN	_	17	appos	_	_
23	with	with	IN	IN	_	28	case	_	_
24	some	some	DT	DT	_	28	det	_	_
25	direct	direct	JJ	JJ	_	28	amod	_	_
26	free-radical	free-radical	JJ	JJ	_	25	dep	_	_
27	scavenging	scavenging	NN	NN	_	28	compound	_	_
28	properties	property	NNS	NNS	_	22	nmod	_	_
29	as	as	RB	RB	_	17	advmod	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	,	,	,	,	_	4	punct	_	_
32	on	on	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	regulation	regulation	NN	NN	_	4	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	HIV-1	hiv-1	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	34	nmod	_	_
38	in	in	IN	IN	_	42	case	_	_
39	latently	latently	RB	RB	_	42	advmod	_	_
40	infected	infected	JJ	JJ	_	42	amod	_	_
41	U1	u1	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	37	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	in	in	IN	IN	_	50	case	_	_
45	productively	productively	RB	RB	_	46	advmod	_	_
46	and	and	CC	CC	_	50	advmod	_	_
47	chronically	chronically	RB	RB	_	46	advmod	_	_
48	infected	infected	JJ	JJ	_	50	amod	_	_
49	U937	u937	NN	NN	_	50	compound	_	_
50	cells	cell	NNS	NNS	_	42	conj	_	_
51	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	antioxidants	antioxidant	NNS	NNS	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	TNF-	tnf-	NN	NN	_	3	dobj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	PMA-induced	pma-induced	JJ	JJ	_	4	conj	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	dep	_	_
10	in	in	IN	IN	_	12	case	_	_
11	U1	u1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	as	as	RB	RB	_	4	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	the	the	DT	DT	_	21	det	_	_
18	sustained	sustained	JJ	JJ	_	21	amod	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	4	conj	_	_
22	permanently	permanently	RB	RB	_	21	advmod	_	_
23	induced	induce	VBN	VBN	_	21	acl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	virus	virus	NN	NN	_	23	nmod	_	_
27	itself	itself	PRP	PRP	_	26	nmod:npmod	_	_
28	in	in	IN	IN	_	32	case	_	_
29	chronically	chronically	RB	RB	_	32	advmod	_	_
30	HIV-infected	hiv-infected	JJ	JJ	_	32	amod	_	_
31	U937	u937	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	23	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	resulted	result	VBD	VBD	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	only	only	RB	RB	_	7	advmod	_	_
5	a	a	DT	DT	_	7	det	_	_
6	partial	partial	JJ	JJ	_	7	amod	_	_
7	inhibition	inhibition	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TNF-	tnf-	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	PMA-induced	pma-induced	JJ	JJ	_	9	conj	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	9	dep	_	_
14	in	in	IN	IN	_	16	case	_	_
15	U1	u1	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	no	no	DT	DT	_	21	neg	_	_
20	detectable	detectable	JJ	JJ	_	21	amod	_	_
21	effect	effect	NN	NN	_	7	conj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	HIV	hiv	NN	NN	_	24	compound	_	_
24	replication	replication	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	chronically	chronically	RB	RB	_	29	advmod	_	_
27	infected	infected	JJ	JJ	_	29	amod	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	6	nsubj	_	_
2	may	may	MD	MD	_	6	aux	_	_
3	be	be	VB	VB	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	limitation	limitation	NN	NN	_	0	root	_	_
7	to	to	TO	TO	_	10	case	_	_
8	potential	potential	JJ	JJ	_	10	amod	_	_
9	antiviral	antiviral	JJ	JJ	_	8	dep	_	_
10	effects	effect	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	antioxidant	antioxidant	JJ	JJ	_	13	amod	_	_
13	therapies	therapy	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Another	another	DT	DT	_	2	det	_	_
2	limitation	limitation	NN	NN	_	3	nsubj	_	_
3	is	be	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	antioxidant	antioxidant	JJ	JJ	_	6	amod	_	_
6	concentrations	concentration	NNS	NNS	_	15	nsubjpass	_	_
7	high	high	JJ	JJ	_	6	amod	_	_
8	enough	enough	RB	RB	_	7	advmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	block	block	VB	VB	_	7	xcomp	_	_
11	NK-kappa	nk-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	dobj	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	3	ccomp	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	have	have	VB	VB	_	15	xcomp	_	_
18	a	a	DT	DT	_	20	det	_	_
19	suppressive	suppressive	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	17	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	functions	function	NNS	NNS	_	17	nmod	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vitro	vitro	FW	FW	_	17	advmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	because	because	IN	IN	_	31	mark	_	_
28	NAC	nac	NN	NN	_	31	nsubj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	BHA	bha	NN	NN	_	28	conj	_	_
31	blocked	block	VBD	VBD	_	15	advcl	_	_
32	IL-2-induced	il-2-induced	JJ	JJ	_	34	amod	_	_
33	PBMC	pbmc	NN	NN	_	34	compound	_	_
34	proliferation	proliferation	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	warrant	warrant	VBP	VBP	_	0	root	_	_
4	prudence	prudence	NN	NN	_	3	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	design	design	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	antioxidant-based	antioxidant-based	JJ	JJ	_	10	amod	_	_
10	therapies	therapy	NNS	NNS	_	7	nmod	_	_
11	aimed	aim	VBN	VBN	_	10	acl	_	_
12	at	at	IN	IN	_	13	mark	_	_
13	suppressing	suppress	VBG	VBG	_	11	advcl	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	CD14-mediated	cd14-mediated	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	2	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	nmod	_	_
10	does	do	VBZ	VBZ	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	require	require	VB	VB	_	0	root	_	_
13	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	12	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	course	course	NN	NN	_	14	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	serious	serious	JJ	JJ	_	7	amod	_	_
6	bacterial	bacterial	JJ	JJ	_	5	dep	_	_
7	infections	infection	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	14	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LPS	lps	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	believed	believe	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	interact	interact	VB	VB	_	14	xcomp	_	_
17	with	with	IN	IN	_	19	case	_	_
18	macrophage	macrophage	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	16	punct	_	_
21	resulting	result	VBG	VBG	_	16	advcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	generation	generation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
27	mediators	mediator	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	systemic	systemic	JJ	JJ	_	30	amod	_	_
30	symptoms	symptom	NNS	NNS	_	24	conj	_	_
31	including	include	VBG	VBG	_	33	case	_	_
32	hemodynamic	hemodynamic	JJ	JJ	_	33	amod	_	_
33	instability	instability	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	shock	shock	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	14	punct	_	_

1	CD14	cd14	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	glycosylphosphatidylinositol-linked	glycosylphosphatidylinositol-linked	JJ	JJ	_	5	amod	_	_
5	antigen	antigen	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	functions	function	VBZ	VBZ	_	0	root	_	_
8	as	as	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	LPS	lps	NN	NN	_	12	compound	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	critical	critical	JJ	JJ	_	3	amod	_	_
3	issue	issue	NN	NN	_	4	nsubj	_	_
4	concerns	concern	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	4	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	17	nmod	_	_
9	CD14	cd14	NN	NN	_	17	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	has	have	VBZ	VBZ	_	9	acl:relcl	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	transmembrane	transmembrane	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	9	punct	_	_
17	transduces	transduce	VBZ	VBZ	_	6	acl:relcl	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	signal	signal	NN	NN	_	17	dobj	_	_
20	following	follow	VBG	VBG	_	22	case	_	_
21	LPS	lps	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	investigators	investigator	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	CD14-mediated	cd14-mediated	JJ	JJ	_	8	amod	_	_
8	signaling	signaling	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	effected	effect	VBN	VBN	_	5	ccomp	_	_
11	through	through	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	receptor-associated	receptor-associated	JJ	JJ	_	15	amod	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	kinase	kinase	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TK	tk	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	10	punct	_	_
20	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
21	a	a	DT	DT	_	24	det	_	_
22	multicomponent	multicomponent	JJ	JJ	_	24	amod	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	model	model	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	LPS	lps	NN	NN	_	27	compound	_	_
27	signaling	signaling	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Wild-type	wild-type	JJ	JJ	_	9	amod	_	_
2	Chinese	chinese	JJ	JJ	_	9	amod	_	_
3	hamster	hamster	NN	NN	_	9	compound	_	_
4	ovary	ovary	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	CHO	cho	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	-K1	-k1	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	endotoxin	endotoxin	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	release	release	VB	VB	_	12	xcomp	_	_
17	arachidonate	arachidonate	NN	NN	_	16	dobj	_	_
18	following	follow	VBG	VBG	_	19	case	_	_
19	transfection	transfection	NN	NN	_	16	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	CD14	cd14	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CHO/CD14	cho/cd14	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	12	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cytosolic	cytosolic	JJ	JJ	_	6	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	correlated	correlate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	LPS-inducible	lps-inducible	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	sought	seek	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	2	ccomp	_	_
5	if	if	IN	IN	_	9	mark	_	_
6	this	this	DT	DT	_	7	det	_	_
7	pathway	pathway	NN	NN	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	present	present	JJ	JJ	_	4	advcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	CHO/CD14	cho/cd14	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	elucidate	elucidate	VB	VB	_	4	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	relationship	relationship	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	17	nmod	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	CD14	cd14	NN	NN	_	26	compound	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	system	system	NN	NN	_	17	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	LPS-stimulated	lps-stimulated	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	CHO/CD14	cho/cd14	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	resembled	resemble	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	same	same	JJ	JJ	_	12	amod	_	_
12	response	response	NN	NN	_	9	xcomp	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	murine	murine	NN	NN	_	18	compound	_	_
16	macrophage-like	macrophage-like	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	12	nmod	_	_
19	RAW	raw	NN	NN	_	18	dep	_	_
20	264.7	264.7	CD	CD	_	19	nummod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	synthesis	synthesis	NN	NN	_	3	compound	_	_
3	inhibitors	inhibitor	NNS	NNS	_	18	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	corticosteroids	corticosteroid	NNS	NNS	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	suppress	suppress	VBP	VBP	_	3	acl:relcl	_	_
9	arachidonate	arachidonate	NN	NN	_	10	compound	_	_
10	release	release	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	synthesis	synthesis	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	proinflammatory	proinflammatory	JJ	JJ	_	16	amod	_	_
16	cytokines	cytokine	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	had	have	VBD	VBD	_	0	root	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	22	case	_	_
22	translocation	translocation	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	CHO/CD14	cho/cd14	NN	NN	_	22	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	RAW	raw	NN	NN	_	31	compound	_	_
30	264.7	264.7	CD	CD	_	31	nummod	_	_
31	cells	cell	NNS	NNS	_	27	conj	_	_
32	,	,	,	,	_	18	punct	_	_
33	demonstrating	demonstrate	VBG	VBG	_	18	advcl	_	_
34	that	that	IN	IN	_	41	mark	_	_
35	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	translocation	translocation	NN	NN	_	41	nsubj	_	_
38	is	be	VBZ	VBZ	_	41	cop	_	_
39	an	a	DT	DT	_	41	det	_	_
40	early	early	JJ	JJ	_	41	amod	_	_
41	event	event	NN	NN	_	33	ccomp	_	_
42	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	TK	tk	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	consistently	consistently	RB	RB	_	6	advmod	_	_
6	observed	observe	VBN	VBN	_	21	advcl	_	_
7	by	by	IN	IN	_	9	case	_	_
8	immunoblotting	immunoblot	VBG	VBG	_	9	amod	_	_
9	extracts	extract	NNS	NNS	_	6	nmod	_	_
10	from	from	IN	IN	_	14	case	_	_
11	activated	activate	VBN	VBN	_	14	amod	_	_
12	RAW	raw	NN	NN	_	14	compound	_	_
13	264.7	264.7	CD	CD	_	14	nummod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	21	punct	_	_
16	LPS-induced	lps-induced	JJ	JJ	_	18	amod	_	_
17	phosphotyrosine	phosphotyrosine	NN	NN	_	18	compound	_	_
18	residues	residue	NNS	NNS	_	21	nsubjpass	_	_
19	were	be	VBD	VBD	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	observed	observe	VBN	VBN	_	0	root	_	_
22	from	from	IN	IN	_	26	case	_	_
23	similarly	similarly	RB	RB	_	24	advmod	_	_
24	treated	treat	VBN	VBN	_	26	amod	_	_
25	CHO/CD14	cho/cd14	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TK	tk	NN	NN	_	5	compound	_	_
5	inhibitors	inhibitor	NNS	NNS	_	10	nsubj	_	_
6	herbimycin	herbimycin	NN	NN	_	7	compound	_	_
7	A	a	NN	NN	_	5	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	genistein	genistein	NN	NN	_	7	conj	_	_
10	failed	fail	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	inhibit	inhibit	VB	VB	_	10	xcomp	_	_
13	translocation	translocation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	CHO/CD14	cho/cd14	NN	NN	_	12	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	RAW	raw	NN	NN	_	22	compound	_	_
21	264.7	264.7	CD	CD	_	22	nummod	_	_
22	cells	cell	NNS	NNS	_	18	conj	_	_
23	,	,	,	,	_	10	punct	_	_
24	although	although	IN	IN	_	29	mark	_	_
25	both	both	DT	DT	_	29	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	agents	agent	NNS	NNS	_	25	nmod	_	_
29	inhibited	inhibit	VBD	VBD	_	10	advcl	_	_
30	LPS-induced	lps-induced	JJ	JJ	_	32	amod	_	_
31	TK	tk	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	29	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	RAW	raw	NN	NN	_	36	compound	_	_
35	264.7	264.7	CD	CD	_	36	nummod	_	_
36	cells	cell	NNS	NNS	_	29	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	TK	tk	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	obligatory	obligatory	JJ	JJ	_	3	ccomp	_	_
10	for	for	IN	IN	_	15	mark	_	_
11	CD14-mediated	cd14-mediated	JJ	JJ	_	13	amod	_	_
12	signal	signal	JJ	JJ	_	13	amod	_	_
13	transduction	transduction	NN	NN	_	15	nsubj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	occur	occur	VB	VB	_	9	advcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	LPS	lps	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Signals	signal	NNS	NNS	_	10	nsubj	_	_
2	transduced	transduce	VBN	VBN	_	1	acl	_	_
3	through	through	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD4	cd4	NN	NN	_	6	compound	_	_
6	molecule	molecule	NN	NN	_	2	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
10	activate	activate	VBP	VBP	_	0	root	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	native	native	JJ	JJ	_	7	amod	_	_
6	envelope	envelope	NN	NN	_	7	compound	_	_
7	glycoproteins	glycoprotein	NNS	NNS	_	13	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	HIV-1	hiv-1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	gp160	gp160	NN	NN	_	7	appos	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	induce	induce	VB	VB	_	3	ccomp	_	_
14	activation	activation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	appos	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	stimulatory	stimulatory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	gp160	gp160	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	through	through	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CD4	cd4	NN	NN	_	11	compound	_	_
11	molecule	molecule	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	since	since	IN	IN	_	18	mark	_	_
14	pretreatment	pretreatment	NN	NN	_	18	nsubj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	soluble	soluble	JJ	JJ	_	17	amod	_	_
17	CD4	cd4	NN	NN	_	14	nmod	_	_
18	abrogates	abrogate	VBZ	VBZ	_	7	advcl	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	gp160-induced	gp160-induced	JJ	JJ	_	5	amod	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	complex	complex	NN	NN	_	6	nsubj	_	_
6	consists	consist	VBZ	VBZ	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p65	p65	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	p50	p50	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	c-rel	c-rel	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	8	conj	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	stimulatory	stimulatory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	gp160	gp160	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	protein	protein	NN	NN	_	13	nmod:npmod	_	_
12	synthesis	synthesis	NN	NN	_	13	nmod:npmod	_	_
13	independent	independent	JJ	JJ	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	dependent	dependent	JJ	JJ	_	13	dep	_	_
17	upon	upon	IN	IN	_	20	case	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	tyrosine	tyrosine	NN	NN	_	20	compound	_	_
20	phosphorylation	phosphorylation	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	abrogated	abrogate	VBN	VBN	_	16	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	inhibitors	inhibitor	NNS	NNS	_	23	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	protein	protein	NN	NN	_	29	compound	_	_
28	kinase	kinase	NN	NN	_	29	compound	_	_
29	C	c	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	gp160-mediated	gp160-mediated	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	CD4	cd4	NN	NN	_	11	compound	_	_
9	positive	positive	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	involved	involve	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	biological	biological	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	e.g.	e.g.	FW	FW	_	17	acl	_	_
20	,	,	,	,	_	17	punct	_	_
21	enhanced	enhance	VBN	VBN	_	23	amod	_	_
22	HIV	hiv	NN	NN	_	23	compound	_	_
23	replication	replication	NN	NN	_	17	appos	_	_
24	,	,	,	,	_	23	punct	_	_
25	hypergammaglobulinemia	hypergammaglobulinemia	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	increased	increase	VBN	VBN	_	29	amod	_	_
28	cytokine	cytokine	NN	NN	_	29	compound	_	_
29	secretion	secretion	NN	NN	_	23	conj	_	_
30	,	,	,	,	_	23	punct	_	_
31	hypercellularity	hypercellularity	NN	NN	_	23	conj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	bone	bone	NN	NN	_	34	compound	_	_
34	marrow	marrow	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	23	cc	_	_
36	apoptosis	apoptosis	NN	NN	_	23	conj	_	_
37	.	.	.	.	_	14	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	phospholipase	phospholipase	NN	NN	_	4	compound	_	_
4	D	d	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	AP-1	ap-1	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	7	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	AP-1	ap-1	NN	NN	_	2	nmod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	5	dep	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	ascribed	ascribe	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	events	event	NNS	NNS	_	10	nmod	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	19	case	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	stimulation	stimulation	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	phospholipase	phospholipase	NN	NN	_	10	compound	_	_
10	D	d	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PLD	pld	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	regulate	regulate	VB	VB	_	5	ccomp	_	_
16	activation	activation	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	AP-1	ap-1	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	16	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	transfecting	transfect	VBG	VBG	_	15	advcl	_	_
27	human	human	JJ	JJ	_	31	amod	_	_
28	T	t	NN	NN	_	31	compound	_	_
29	lymphocyte	lymphocyte	NN	NN	_	31	compound	_	_
30	Jurkat	jurkat	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	26	dobj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	plasmid	plasmid	NN	NN	_	26	nmod	_	_
35	containing	contain	VBG	VBG	_	34	acl	_	_
36	an	a	DT	DT	_	39	det	_	_
37	AP-1	ap-1	NN	NN	_	39	compound	_	_
38	enhancer	enhancer	NN	NN	_	39	compound	_	_
39	element	element	NN	NN	_	35	dobj	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	a	a	DT	DT	_	45	det	_	_
42	chloramphenicol	chloramphenicol	NN	NN	_	45	compound	_	_
43	acetyltransferase	acetyltransferase	NN	NN	_	45	compound	_	_
44	reporter	reporter	NN	NN	_	45	compound	_	_
45	gene	gene	NN	NN	_	39	conj	_	_
46	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	detected	detect	VBN	VBN	_	0	root	_	_
4	activatable	activatable	JJ	JJ	_	5	amod	_	_
5	PLD	pld	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	found	find	VBN	VBN	_	3	conj	_	_
14	that	that	IN	IN	_	34	mark	_	_
15	addition	addition	NN	NN	_	34	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	phosphatidic	phosphatidic	JJ	JJ	_	18	amod	_	_
18	acid	acid	NN	NN	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PA	pa	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	the	the	DT	DT	_	25	det	_	_
24	physiologic	physiologic	JJ	JJ	_	25	amod	_	_
25	product	product	NN	NN	_	18	appos	_	_
26	of	of	IN	IN	_	28	case	_	_
27	PLD	pld	NN	NN	_	28	compound	_	_
28	action	action	NN	NN	_	25	nmod	_	_
29	on	on	IN	IN	_	30	case	_	_
30	phospholipids	phospholipid	NNS	NNS	_	28	nmod	_	_
31	,	,	,	,	_	15	punct	_	_
32	is	be	VBZ	VBZ	_	34	auxpass	_	_
33	rapidly	rapidly	RB	RB	_	34	advmod	_	_
34	incorporated	incorporate	VBN	VBN	_	13	ccomp	_	_
35	into	into	IN	IN	_	37	case	_	_
36	Jurkat	jurkat	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	leads	lead	VBZ	VBZ	_	34	conj	_	_
40	to	to	TO	TO	_	41	case	_	_
41	activation	activation	NN	NN	_	39	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	transcription	transcription	NN	NN	_	45	compound	_	_
44	factor	factor	NN	NN	_	45	compound	_	_
45	AP-1	ap-1	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Jurkat	jurkat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	anti-CD3	anti-cd3	JJ	JJ	_	7	amod	_	_
7	mAb	mab	NN	NN	_	1	nmod	_	_
8	activated	activate	VBD	VBD	_	0	root	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	PLD	pld	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	AP-1	ap-1	NN	NN	_	10	conj	_	_
15	.	.	.	.	_	8	punct	_	_

1	Wortmannin	wortmannin	NN	NN	_	10	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	4	det	_	_
4	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	8	case	_	_
6	receptor-coupled	receptor-coupled	JJ	JJ	_	8	amod	_	_
7	PLD	pld	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	13	amod	_	_
13	increases	increase	NNS	NNS	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	PLD	pld	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	10	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	AP-1	ap-1	NN	NN	_	21	compound	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	good	good	JJ	JJ	_	5	amod	_	_
5	correlation	correlation	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transfected	transfect	VBN	VBN	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	PLD	pld	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	induction	induction	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	AP-1	ap-1	NN	NN	_	18	compound	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	under	under	IN	IN	_	22	case	_	_
20	different	different	JJ	JJ	_	22	amod	_	_
21	experimental	experimental	JJ	JJ	_	20	dep	_	_
22	conditions	condition	NNS	NNS	_	5	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	ethanol	ethanol	NN	NN	_	12	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	an	a	DT	DT	_	6	det	_	_
6	inhibitor	inhibitor	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	PLD	pld	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	blocked	block	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	17	det	_	_
14	anti-CD3-stimulated	anti-cd3-stimulated	JJ	JJ	_	17	amod	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	enhancer	enhancer	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	12	dobj	_	_
18	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	anti-CD3-mediated	anti-cd3-mediated	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	neomycin	neomycin	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	16	case	_	_
15	phosphoinositide	phosphoinositide	JJ	JJ	_	16	amod	_	_
16	hydrolysis	hydrolysis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	increases	increase	NNS	NNS	_	15	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	AP-1	ap-1	NN	NN	_	6	compound	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	PA	pa	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	anti-CD3	anti-cd3	JJ	JJ	_	12	amod	_	_
12	mAb	mab	NN	NN	_	9	conj	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	efficiently	efficiently	RB	RB	_	15	advmod	_	_
15	abrogated	abrogate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	presence	presence	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	propranolol	propranolol	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	an	a	DT	DT	_	23	det	_	_
23	inhibitor	inhibitor	NN	NN	_	20	appos	_	_
24	of	of	IN	IN	_	26	case	_	_
25	PA	pa	NN	NN	_	26	compound	_	_
26	phosphohydrolase	phosphohydrolase	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	protein	protein	NN	NN	_	30	compound	_	_
29	kinase	kinase	NN	NN	_	30	compound	_	_
30	C	c	NN	NN	_	26	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	PKC	pkc	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	15	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	PA-	pa-	NN	NN	_	14	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	4	conj	_	_
8	increases	increase	NNS	NNS	_	4	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	AP-1	ap-1	NN	NN	_	12	compound	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	4	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	presence	presence	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	PKC	pkc	NN	NN	_	20	compound	_	_
20	inhibitors	inhibitor	NNS	NNS	_	17	nmod	_	_
21	or	or	CC	CC	_	17	cc	_	_
22	by	by	IN	IN	_	24	case	_	_
23	PKC	pkc	NN	NN	_	24	compound	_	_
24	down-regulation	down-regulation	NN	NN	_	17	conj	_	_
25	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	PLD	pld	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	activate	activate	VB	VB	_	3	ccomp	_	_
9	the	the	DT	DT	_	12	det	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	AP-1	ap-1	NN	NN	_	8	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	suggest	suggest	VBP	VBP	_	3	conj	_	_
19	that	that	IN	IN	_	30	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	induction	induction	NN	NN	_	30	nsubjpass	_	_
22	of	of	IN	IN	_	26	case	_	_
23	AP-1	ap-1	NN	NN	_	26	compound	_	_
24	enhancer	enhancer	NN	NN	_	26	compound	_	_
25	factor	factor	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	21	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	PA	pa	NN	NN	_	21	nmod	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	mediated	mediate	VBN	VBN	_	18	ccomp	_	_
31	via	via	IN	IN	_	33	case	_	_
32	PKC	pkc	NN	NN	_	33	compound	_	_
33	stimulation	stimulation	NN	NN	_	30	advcl	_	_
34	,	,	,	,	_	33	punct	_	_
35	either	either	CC	CC	_	40	cc:preconj	_	_
36	through	through	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	direct	direct	JJ	JJ	_	40	amod	_	_
39	activating	activating	NN	NN	_	40	compound	_	_
40	effect	effect	NN	NN	_	33	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	PA	pa	NN	NN	_	40	nmod	_	_
43	or	or	CC	CC	_	40	cc	_	_
44	through	through	IN	IN	_	47	case	_	_
45	PA-derived	pa-derived	JJ	JJ	_	47	amod	_	_
46	diacylglycerol	diacylglycerol	NN	NN	_	47	compound	_	_
47	formation	formation	NN	NN	_	40	conj	_	_
48	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	provide	provide	VBP	VBP	_	0	root	_	_
5	evidence	evidence	NN	NN	_	4	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	PLD-derived	pld-derived	JJ	JJ	_	11	amod	_	_
11	lipids	lipid	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	AP-1	ap-1	NN	NN	_	18	compound	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	resulting	result	VBG	VBG	_	14	acl	_	_
20	from	from	IN	IN	_	21	case	_	_
21	stimulation	stimulation	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	TCR/CD3	tcr/cd3	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	4	punct	_	_
27	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
28	that	that	IN	IN	_	33	mark	_	_
29	increased	increase	VBN	VBN	_	31	amod	_	_
30	PLD	pld	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	33	nsubj	_	_
32	can	can	MD	MD	_	33	aux	_	_
33	play	play	VB	VB	_	27	ccomp	_	_
34	an	a	DT	DT	_	36	det	_	_
35	important	important	JJ	JJ	_	36	amod	_	_
36	role	role	NN	NN	_	33	dobj	_	_
37	in	in	IN	IN	_	40	case	_	_
38	T	t	NN	NN	_	40	compound	_	_
39	lymphocyte	lymphocyte	NN	NN	_	40	compound	_	_
40	activation	activation	NN	NN	_	33	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-8	il-8	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	uses	use	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	CD28	cd28	NN	NN	_	12	compound	_	_
11	costimulatory	costimulatory	JJ	JJ	_	12	amod	_	_
12	pathway	pathway	NN	NN	_	8	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	IL-8	il-8	NN	NN	_	16	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	chemotactic	chemotactic	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	1	appos	_	_
7	for	for	IN	IN	_	9	case	_	_
8	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
9	granulocytes	granulocyte	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	9	conj	_	_
12	,	,	,	,	_	1	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	proinflammatory	proinflammatory	JJ	JJ	_	16	amod	_	_
16	cytokine	cytokine	NN	NN	_	0	root	_	_
17	secreted	secrete	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	variety	variety	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	types	type	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	including	include	VBG	VBG	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	Stimulation	stimulation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	CD28	cd28	NN	NN	_	7	compound	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	surface	surface	NN	NN	_	7	compound	_	_
7	molecule	molecule	NN	NN	_	1	nmod	_	_
8	delivers	deliver	VBZ	VBZ	_	0	root	_	_
9	costimulatory	costimulatory	JJ	JJ	_	10	amod	_	_
10	signals	signal	NNS	NNS	_	8	dobj	_	_
11	essential	essential	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	lymphokine	lymphokine	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	via	via	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	conserved	conserve	VBN	VBN	_	23	amod	_	_
22	sequence	sequence	NN	NN	_	23	compound	_	_
23	element	element	NN	NN	_	8	nmod	_	_
24	found	find	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	promoter	promoter	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	several	several	JJ	JJ	_	31	amod	_	_
30	lymphokine	lymphokine	NN	NN	_	31	compound	_	_
31	genes	gene	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Anti-CD28-stimulated	anti-cd28-stimulated	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	produced	produce	VBD	VBD	_	0	root	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	amounts	amount	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-8	il-8	NN	NN	_	6	nmod	_	_
9	;	;	:	:	_	4	punct	_	_
10	additionally	additionally	RB	RB	_	18	advmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	costimulation	costimulation	NN	NN	_	18	nsubj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	anti-CD3	anti-cd3	JJ	JJ	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	anti-CD28	anti-cd28	JJ	JJ	_	17	amod	_	_
17	Abs	ab	NNS	NNS	_	14	conj	_	_
18	resulted	result	VBD	VBD	_	4	parataxis	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	synergistic	synergistic	JJ	JJ	_	22	amod	_	_
22	induction	induction	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	IL-8	il-8	NN	NN	_	25	compound	_	_
25	secretion	secretion	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	homology	homology	NN	NN	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	single	single	JJ	JJ	_	6	amod	_	_
5	nucleotide	nucleotide	JJ	JJ	_	4	dep	_	_
6	mutations	mutation	NNS	NNS	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	anti-CD28	anti-cd28	JJ	JJ	_	11	amod	_	_
10	Ab	ab	NN	NN	_	11	compound	_	_
11	stimulation	stimulation	NN	NN	_	2	conj	_	_
12	studies	study	NNS	NNS	_	2	dep	_	_
13	established	establish	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	26	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B-like	b-like	JJ	JJ	_	18	amod	_	_
18	sequence	sequence	NN	NN	_	26	nsubj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-8	il-8	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	21	nmod	_	_
26	functioned	function	VBD	VBD	_	13	ccomp	_	_
27	as	as	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	CD28	cd28	NN	NN	_	31	compound	_	_
30	response	response	NN	NN	_	31	compound	_	_
31	element	element	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	cyclosporin	cyclosporin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	10	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	rapamycin	rapamycin	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	synergistic	synergistic	JJ	JJ	_	13	amod	_	_
13	induction	induction	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	IL-8	il-8	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	achieved	achieve	VBN	VBN	_	13	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	anti-CD3	anti-cd3	JJ	JJ	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	anti-CD28	anti-cd28	JJ	JJ	_	19	conj	_	_
22	costimulation	costimulation	NN	NN	_	19	dep	_	_
23	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	CD28	cd28	NN	NN	_	7	compound	_	_
6	response	response	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	IL-8	il-8	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	provide	provide	VB	VB	_	0	root	_	_
20	new	new	JJ	JJ	_	21	amod	_	_
21	insights	insight	NNS	NNS	_	19	dobj	_	_
22	into	into	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	pathogenesis	pathogenesis	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	persistence	persistence	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	disorders	disorder	NNS	NNS	_	24	nmod	_	_
30	characterized	characterize	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	33	case	_	_
32	increased	increase	VBN	VBN	_	33	amod	_	_
33	levels	level	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	IL-8	il-8	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	29	punct	_	_
37	such	such	JJ	JJ	_	39	case	_	_
38	as	as	IN	IN	_	37	mwe	_	_
39	psoriasis	psoriasis	NN	NN	_	29	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	rheumatoid	rheumatoid	NN	NN	_	42	compound	_	_
42	arthritis	arthritis	NN	NN	_	39	conj	_	_
43	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	severe	severe	JJ	JJ	_	3	amod	_	_
3	phenotype	phenotype	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	females	female	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	tiny	tiny	JJ	JJ	_	10	amod	_	_
8	ring	ring	NN	NN	_	10	compound	_	_
9	X	x	NN	NN	_	10	compound	_	_
10	chromosomes	chromosome	NNS	NNS	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	inability	inability	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	chromosomes	chromosome	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	undergo	undergo	VB	VB	_	14	acl	_	_
20	X	x	NN	NN	_	21	compound	_	_
21	inactivation	inactivation	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	12	punct	_	_

1	Mental	mental	JJ	JJ	_	2	amod	_	_
2	retardation	retardation	NN	NN	_	16	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	a	a	DT	DT	_	5	det	_	_
5	constellation	constellation	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	congenital	congenital	JJ	JJ	_	8	amod	_	_
8	malformations	malformation	NNS	NNS	_	5	nmod	_	_
9	not	not	RB	RB	_	2	neg	_	_
10	usually	usually	RB	RB	_	2	advmod	_	_
11	associated	associate	VBN	VBN	_	2	acl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	Turner	turner	NN	NN	_	14	compound	_	_
14	syndrome	syndrome	NN	NN	_	11	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	seen	see	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	some	some	DT	DT	_	19	det	_	_
19	females	female	NNS	NNS	_	16	nmod	_	_
20	with	with	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	mosaic	mosaic	JJ	JJ	_	24	amod	_	_
23	45,X/46,X,r(X)	45,x/46,x,r(x)	NN	NN	_	24	compound	_	_
24	karyotype	karyotype	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Studies	study	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	females	female	NNS	NNS	_	1	nmod	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	XIST	xist	NN	NN	_	9	compound	_	_
9	locus	locus	NN	NN	_	17	nsubj	_	_
10	on	on	IN	IN	_	15	case	_	_
11	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
12	tiny	tiny	JJ	JJ	_	15	amod	_	_
13	ring	ring	NN	NN	_	15	compound	_	_
14	X	x	NN	NN	_	15	compound	_	_
15	chromosomes	chromosome	NNS	NNS	_	9	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	either	either	CC	CC	_	5	ccomp	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	present	present	JJ	JJ	_	17	dep	_	_
20	or	or	CC	CC	_	17	cc	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	expressed	express	VBN	VBN	_	17	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	6	mark	_	_
2	XIST	xist	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	well	well	RB	RB	_	6	advmod	_	_
6	correlated	correlate	VBN	VBN	_	29	advcl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	inactivation	inactivation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	X	x	NN	NN	_	12	compound	_	_
12	chromosome	chromosome	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	female	female	JJ	JJ	_	16	amod	_	_
15	somatic	somatic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	spermatogonia	spermatogonia	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	29	punct	_	_
20	nonexpression	nonexpression	NN	NN	_	29	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	locus	locus	NN	NN	_	20	nmod	_	_
24	even	even	RB	RB	_	25	advmod	_	_
25	when	when	WRB	WRB	_	28	advmod	_	_
26	it	it	PRP	PRP	_	28	nsubj	_	_
27	is	be	VBZ	VBZ	_	28	cop	_	_
28	present	present	JJ	JJ	_	29	advcl	_	_
29	suggests	suggest	VBZ	VBZ	_	0	root	_	_
30	that	that	IN	IN	_	35	mark	_	_
31	these	these	DT	DT	_	32	det	_	_
32	chromosomes	chromosome	NNS	NNS	_	35	nsubj	_	_
33	are	be	VBP	VBP	_	35	cop	_	_
34	transcriptionally	transcriptionally	RB	RB	_	35	advmod	_	_
35	active	active	JJ	JJ	_	29	ccomp	_	_
36	.	.	.	.	_	29	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	ring	ring	NN	NN	_	9	compound	_	_
8	X	x	NN	NN	_	9	compound	_	_
9	chromosomes	chromosome	NNS	NNS	_	5	nmod	_	_
10	lacking	lack	VBG	VBG	_	9	acl	_	_
11	XIST	xist	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	XISTE-	xiste-	JJ	JJ	_	12	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	9	punct	_	_
17	from	from	IN	IN	_	19	case	_	_
18	three	three	CD	CD	_	19	nummod	_	_
19	females	female	NNS	NNS	_	9	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	severe	severe	JJ	JJ	_	22	amod	_	_
22	phenotypes	phenotype	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	tiny	tiny	JJ	JJ	_	6	amod	_	_
4	ring	ring	NN	NN	_	6	compound	_	_
5	X	x	NN	NN	_	6	compound	_	_
6	chromosomes	chromosome	NNS	NNS	_	24	nsubjpass	_	_
7	studied	study	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	antibody	antibody	NN	NN	_	7	nmod	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	acetylated	acetylate	VBN	VBN	_	15	amod	_	_
15	isoforms	isoform	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	histone	histone	NN	NN	_	18	compound	_	_
18	H4	h4	NN	NN	_	15	nmod	_	_
19	marking	mark	VBG	VBG	_	18	acl	_	_
20	transcribed	transcribe	VBN	VBN	_	22	amod	_	_
21	chromatin	chromatin	NN	NN	_	22	compound	_	_
22	domains	domain	NNS	NNS	_	19	dobj	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	labeled	label	VBN	VBN	_	0	root	_	_
25	at	at	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	level	level	NN	NN	_	24	nmod	_	_
28	consistent	consistent	JJ	JJ	_	27	amod	_	_
29	with	with	IN	IN	_	32	mark	_	_
30	their	they	PRP$	PRP$	_	32	nsubj	_	_
31	being	be	VBG	VBG	_	32	cop	_	_
32	active	active	JJ	JJ	_	28	advcl	_	_
33	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	tow	tow	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	XISTE-	xiste-	JJ	JJ	_	9	amod	_	_
8	ring	ring	NN	NN	_	9	compound	_	_
9	chromosomes	chromosome	NNS	NNS	_	4	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	determine	determine	VB	VB	_	3	advcl	_	_
12	whether	whether	IN	IN	_	23	mark	_	_
13	genes	gene	NNS	NNS	_	23	nsubjpass	_	_
14	that	that	WDT	WDT	_	17	nsubj	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	normally	normally	RB	RB	_	17	advmod	_	_
17	silent	silent	JJ	JJ	_	13	acl:relcl	_	_
18	on	on	IN	IN	_	21	case	_	_
19	an	a	DT	DT	_	21	det	_	_
20	inactive	inactive	JJ	JJ	_	21	amod	_	_
21	X	x	NN	NN	_	17	nmod	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	expressed	express	VBN	VBN	_	11	ccomp	_	_
24	from	from	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	chromosomes	chromosome	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Analyses	analysis	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	hybrid	hybrid	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	32	mark	_	_
7	TIMP	timp	NN	NN	_	32	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	ZXDA	zxda	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	ZXDB	zxdb	NN	NN	_	13	compound	_	_
13	loci	locus	NNS	NNS	_	7	conj	_	_
14	on	on	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	proximal	proximal	JJ	JJ	_	18	amod	_	_
17	short	short	JJ	JJ	_	18	amod	_	_
18	arm	arm	NN	NN	_	7	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	AR	ar	NN	NN	_	7	conj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	PHKA1	phka1	NN	NN	_	24	compound	_	_
24	loci	locus	NNS	NNS	_	21	conj	_	_
25	on	on	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	long	long	JJ	JJ	_	28	amod	_	_
28	arm	arm	NN	NN	_	21	nmod	_	_
29	,	,	,	,	_	7	punct	_	_
30	are	be	VBP	VBP	_	32	auxpass	_	_
31	well	well	RB	RB	_	32	advmod	_	_
32	expressed	express	VBN	VBN	_	5	ccomp	_	_
33	from	from	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	tiny	tiny	JJ	JJ	_	38	amod	_	_
36	ring	ring	NN	NN	_	38	compound	_	_
37	X	x	NN	NN	_	38	compound	_	_
38	chromosome	chromosome	NN	NN	_	32	nmod	_	_
39	lacking	lack	VBG	VBG	_	38	acl	_	_
40	XIST	xist	NN	NN	_	41	compound	_	_
41	DNA	dna	NN	NN	_	39	dobj	_	_
42	.	.	.	.	_	5	punct	_	_

1	Studies	study	NNS	NNS	_	15	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	ring	ring	NN	NN	_	5	compound	_	_
5	chromosome	chromosome	NN	NN	_	1	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	5	acl:relcl	_	_
8	XIST	xist	NN	NN	_	9	compound	_	_
9	DNA	dna	NN	NN	_	7	dobj	_	_
10	but	but	CC	CC	_	7	cc	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	transcribe	transcribe	VB	VB	_	7	conj	_	_
14	it	it	PRP	PRP	_	13	dobj	_	_
15	show	show	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	AR	ar	NN	NN	_	19	compound	_	_
19	allele	allele	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	transcribed	transcribe	VBN	VBN	_	15	ccomp	_	_
22	along	along	IN	IN	_	25	case	_	_
23	with	with	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	one	one	NN	NN	_	21	nmod	_	_
26	on	on	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	normal	normal	JJ	JJ	_	30	amod	_	_
29	X	x	NN	NN	_	30	compound	_	_
30	allele	allele	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Signals	signal	NNS	NNS	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factors	factor	NNS	NNS	_	1	conj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	regulate	regulate	VBP	VBP	_	1	acl:relcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	interleukin-4	interleukin-4	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	interleukin-5	interleukin-5	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	10	dep	_	_
14	in	in	IN	IN	_	17	case	_	_
15	helper	helper	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Mouse	mouse	NN	NN	_	5	compound	_	_
2	thymoma	thymoma	NN	NN	_	5	compound	_	_
3	line	line	NN	NN	_	5	compound	_	_
4	EL-4	el-4	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	produce	produce	VBP	VBP	_	0	root	_	_
7	cytokines	cytokine	NNS	NNS	_	6	dobj	_	_
8	such	such	JJ	JJ	_	12	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	interleukin	interleukin	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL	il	NN	NN	_	7	nmod	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-2	-2	CD	CD	_	12	nummod	_	_
15	,	,	,	,	_	12	punct	_	_
16	IL-3	il-3	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	IL-4	il-4	NN	NN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	IL-10	il-10	NN	NN	_	12	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	25	amod	_	_
24	colony-stimulating	colony-stimulating	JJ	JJ	_	25	amod	_	_
25	factor	factor	NN	NN	_	12	conj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	6	nmod	_	_
28	to	to	TO	TO	_	31	case	_	_
29	phorbol	phorbol	NN	NN	_	31	compound	_	_
30	12-myristate	12-myristate	NN	NN	_	31	compound	_	_
31	13-acetate	13-acetate	NN	NN	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	PMA	pma	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	6	punct	_	_

1	EL-4	el-4	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	produce	produce	VBP	VBP	_	0	root	_	_
5	low	low	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-5	il-5	NN	NN	_	6	nmod	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	stimulated	stimulate	VBN	VBN	_	4	advcl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	PMA	pma	NN	NN	_	10	nmod	_	_
13	alone	alone	RB	RB	_	12	advmod	_	_
14	;	;	:	:	_	4	punct	_	_
15	however	however	RB	RB	_	19	advmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	cAMP	camp	NN	NN	_	19	nsubj	_	_
18	greatly	greatly	RB	RB	_	19	advmod	_	_
19	augments	augment	VBZ	VBZ	_	4	parataxis	_	_
20	PMA-dependent	pma-dependent	JJ	JJ	_	22	amod	_	_
21	IL-5	il-5	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	signals	signal	NNS	NNS	_	15	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	PMA	pma	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cAMP	camp	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	5	ccomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	optimal	optimal	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-5	il-5	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	cAMP	camp	NN	NN	_	7	nsubj	_	_
5	almost	almost	RB	RB	_	6	advmod	_	_
6	completely	completely	RB	RB	_	7	advmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	PMA-dependent	pma-dependent	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	as	as	RB	RB	_	15	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transfected	transfect	VBN	VBN	_	23	amod	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	15	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-5	il-5	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	positively	positively	RB	RB	_	10	advmod	_	_
10	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
11	by	by	IN	IN	_	12	case	_	_
12	cAMP	camp	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	manner	manner	NN	NN	_	10	nmod	_	_
16	opposite	opposite	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	21	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	NFs	nf	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	regulates	regulate	VBZ	VBZ	_	1	acl:relcl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	response	response	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-5	il-5	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	cAMP	camp	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	PMA	pma	NN	NN	_	18	conj	_	_
21	has	have	VBZ	VBZ	_	0	root	_	_
22	properties	property	NNS	NNS	_	21	dobj	_	_
23	similar	similar	JJ	JJ	_	22	amod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	NF	nf	NN	NN	_	23	nmod	_	_
26	for	for	IN	IN	_	29	case	_	_
27	activated	activate	VBN	VBN	_	29	amod	_	_
28	t	t	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	P	p	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	23	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	defined	define	VBN	VBN	_	3	acl	_	_
10	as	as	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	responsive	responsive	JJ	JJ	_	13	amod	_	_
13	element	element	NN	NN	_	9	nmod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	PMA	pma	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	calcium	calcium	NN	NN	_	18	compound	_	_
18	ionophore	ionophore	NN	NN	_	15	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	A23187	a23187	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	3	punct	_	_
23	shares	share	VBZ	VBZ	_	0	root	_	_
24	sequence	sequence	NN	NN	_	25	compound	_	_
25	similarity	similarity	NN	NN	_	23	dobj	_	_
26	with	with	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	NF	nf	NN	NN	_	30	compound	_	_
29	kappa	kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	35	det	_	_
33	NF-activated	nf-activated	JJ	JJ	_	35	amod	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cell	cell	NN	NN	_	30	conj	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	sites	site	NNS	NNS	_	30	dep	_	_
38	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	attempted	attempt	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	2	xcomp	_	_
5	whether	whether	IN	IN	_	18	mark	_	_
6	NF(P)	nf(p)	NN	NN	_	18	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	6	appos	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	P	p	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	related	related	JJ	JJ	_	4	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
24	factor	factor	NN	NN	_	28	compound	_	_
25	for	for	IN	IN	_	28	amod	_	_
26	activated	activate	VBN	VBN	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cell	cell	NN	NN	_	21	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	NF-AT	nf-at	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	electromobility	electromobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	16	nmod	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	16	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	P65	p65	NN	NN	_	7	dep	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	P65/P50	p65/p50	NN	NN	_	12	compound	_	_
12	heterodimer	heterodimer	NN	NN	_	9	conj	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	NF-AT	nf-at	NN	NN	_	7	conj	_	_
16	bound	bind	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	P	p	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	specificity	specificity	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NF-AT	nf-at	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	that	that	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF(P)	nf(p)	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	only	only	RB	RB	_	19	advmod	_	_
17	a	a	DT	DT	_	19	det	_	_
18	small	small	JJ	JJ	_	19	amod	_	_
19	amount	amount	NN	NN	_	23	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	P65	p65	NN	NN	_	19	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	detected	detect	VBN	VBN	_	9	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	NF(P)	nf(p)	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	component	component	NN	NN	_	11	nsubj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	components	component	NNS	NNS	_	6	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-AT	nf-at	NN	NN	_	6	nmod	_	_
11	have	have	VBP	VBP	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	potential	potential	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	reconstitute	reconstitute	VB	VB	_	13	acl	_	_
16	NF(P)	nf(p)	NN	NN	_	15	dobj	_	_
17	,	,	,	,	_	11	punct	_	_
18	whereas	whereas	IN	IN	_	24	mark	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	24	nsubj	_	_
21	alone	alone	RB	RB	_	20	advmod	_	_
22	does	do	VBZ	VBZ	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	account	account	VB	VB	_	11	advcl	_	_
25	for	for	IN	IN	_	26	case	_	_
26	NF(P)	nf(p)	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	Jurkat	jurkat	NN	NN	_	30	compound	_	_
29	crude	crude	JJ	JJ	_	30	amod	_	_
30	extract	extract	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	NF-AT-like	nf-at-like	JJ	JJ	_	9	amod	_	_
9	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	involved	involve	VBN	VBN	_	6	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-4	il-4	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-5	il-5	NN	NN	_	16	conj	_	_
19	genes	gene	NNS	NNS	_	16	dep	_	_
20	.	.	.	.	_	1	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	interleukin-4-induced	interleukin-4-induced	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	Stat	stat	NN	NN	_	4	dep	_	_
8	.	.	.	.	_	4	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-4	il-4	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	immunomodulatory	immunomodulatory	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	0	root	_	_
9	secreted	secrete	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	basophils	basophil	NNS	NNS	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	mast	mast	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	13	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	plays	play	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	modulating	modulate	VBG	VBG	_	2	advcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	balance	balance	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	17	case	_	_
11	T	t	NN	NN	_	17	compound	_	_
12	helper	helper	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	Th	th	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	subsets	subset	NNS	NNS	_	9	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	favoring	favor	VBG	VBG	_	2	advcl	_	_
20	expansion	expansion	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Th2	th2	NN	NN	_	24	compound	_	_
24	lineage	lineage	NN	NN	_	20	nmod	_	_
25	relative	relative	JJ	JJ	_	24	amod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	Th1	th1	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Imbalance	imbalance	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	these	these	DT	DT	_	6	det	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	subsets	subset	NNS	NNS	_	1	nmod	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	implicated	implicate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	immunological	immunological	JJ	JJ	_	12	amod	_	_
12	diseases	disease	NNS	NNS	_	9	nmod	_	_
13	including	include	VBG	VBG	_	14	case	_	_
14	allergy	allergy	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	inflammation	inflammation	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	autoimmune	autoimmune	JJ	JJ	_	20	amod	_	_
20	disease	disease	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	IL-4	il-4	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	mediate	mediate	VB	VB	_	0	root	_	_
4	its	its	PRP$	PRP$	_	6	nmod:poss	_	_
5	biological	biological	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	3	dobj	_	_
7	,	,	,	,	_	3	punct	_	_
8	at	at	IN	IN	_	11	advmod	_	_
9	least	least	JJS	JJS	_	8	mwe	_	_
10	in	in	IN	IN	_	11	case	_	_
11	part	part	NN	NN	_	3	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	activating	activate	VBG	VBG	_	3	advcl	_	_
15	a	a	DT	DT	_	19	det	_	_
16	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	19	amod	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	14	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	now	now	RB	RB	_	6	advmod	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	purified	purify	VBN	VBN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	encoding	encoding	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	11	nsubj	_	_
11	cloned	clone	VBN	VBN	_	6	conj	_	_
12	.	.	.	.	_	6	punct	_	_

1	Examination	examination	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	primary	primary	JJ	JJ	_	7	amod	_	_
5	amino	amino	NN	NN	_	7	compound	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	protein	protein	NN	NN	_	7	nmod	_	_
11	indicates	indicate	VBZ	VBZ	_	0	root	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	it	it	PRP	PRP	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	member	member	NN	NN	_	11	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	transducers	transducer	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	activators	activator	NNS	NNS	_	28	compound	_	_
23	of	of	IN	IN	_	28	amod	_	_
24	transcription	transcription	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	Stat	stat	NN	NN	_	28	compound	_	_
27	)	)	-RRB-	-RRB-	_	28	punct	_	_
28	family	family	NN	NN	_	20	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	DNA	dna	NN	NN	_	32	compound	_	_
31	binding	binding	NN	NN	_	32	compound	_	_
32	proteins	protein	NNS	NNS	_	20	nmod	_	_
33	,	,	,	,	_	20	punct	_	_
34	hereby	hereby	RB	RB	_	35	advmod	_	_
35	designated	designate	VBN	VBN	_	20	acl	_	_
36	IL-4	il-4	NN	NN	_	37	compound	_	_
37	Stat	stat	NN	NN	_	35	xcomp	_	_
38	.	.	.	.	_	11	punct	_	_

1	Study	study	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	activities	activity	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	phosphotyrosine-containing	phosphotyrosine-containing	JJ	JJ	_	8	amod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	derived	derive	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
13	domain	domain	NN	NN	_	17	compound	_	_
14	of	of	IN	IN	_	17	amod	_	_
15	the	the	DT	DT	_	17	det	_	_
16	IL-4	il-4	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	9	nmod	_	_
18	provided	provide	VBD	VBD	_	0	root	_	_
19	evidence	evidence	NN	NN	_	18	dobj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	direct	direct	JJ	JJ	_	22	amod	_	_
22	coupling	coupling	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	receptor	receptor	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	24	conj	_	_
28	during	during	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	IL-4	il-4	NN	NN	_	33	compound	_	_
31	Stat	stat	NN	NN	_	33	compound	_	_
32	activation	activation	NN	NN	_	33	compound	_	_
33	cycle	cycle	NN	NN	_	22	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	Stat	stat	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	same	same	JJ	JJ	_	11	amod	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	7	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	receptor	receptor	NN	NN	_	7	nmod	_	_
15	coupling	coupling	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	dimerization	dimerization	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Structure	structure	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	expression	expression	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	GATA3	gata3	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	GATA3	gata3	NN	NN	_	19	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	member	member	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	GATA	gata	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	4	nmod	_	_
9	that	that	WDT	WDT	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	abundantly	abundantly	RB	RB	_	12	advmod	_	_
12	expressed	express	VBN	VBN	_	1	acl:relcl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	T-lymphocyte	t-lymphocyte	NN	NN	_	16	compound	_	_
16	lineage	lineage	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	thought	think	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	participate	participate	VB	VB	_	19	xcomp	_	_
22	in	in	IN	IN	_	26	case	_	_
23	T-cell	t-cell	NN	NN	_	26	compound	_	_
24	receptor	receptor	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	21	nmod	_	_
27	through	through	IN	IN	_	28	case	_	_
28	binding	binding	NN	NN	_	21	nmod	_	_
29	to	to	TO	TO	_	30	case	_	_
30	enhancers	enhancer	NNS	NNS	_	28	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	GATA3	gata3	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	regulation	regulation	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	cloned	clone	VBD	VBD	_	2	parataxis	_	_
9	the	the	DT	DT	_	11	det	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	5'	5'	NN	NN	_	15	compound	_	_
15	end	end	NN	NN	_	11	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	mouse	mouse	NN	NN	_	20	compound	_	_
19	GATA3	gata3	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	GATA3	gata3	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	nsubj	_	_
8	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
9	six	six	CD	CD	_	10	nummod	_	_
10	exons	exon	NNS	NNS	_	8	dobj	_	_
11	distributed	distribute	VBN	VBN	_	10	acl	_	_
12	over	over	IN	IN	_	14	case	_	_
13	17	17	CD	CD	_	14	nummod	_	_
14	kb	kb	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	DNA	dna	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	two	two	CD	CD	_	6	nummod	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	GATA3	gata3	NN	NN	_	6	compound	_	_
5	zinc	zinc	NN	NN	_	6	compound	_	_
6	fingers	finger	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	encoded	encode	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	separate	separate	JJ	JJ	_	12	amod	_	_
12	exons	exon	NNS	NNS	_	8	nmod	_	_
13	highly	highly	RB	RB	_	14	advmod	_	_
14	conserved	conserve	VBN	VBN	_	12	acl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	GATA1	gata1	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	but	but	CC	CC	_	8	cc	_	_
21	no	no	DT	DT	_	24	neg	_	_
22	other	other	JJ	JJ	_	24	amod	_	_
23	structural	structural	JJ	JJ	_	22	dep	_	_
24	homologies	homology	NNS	NNS	_	31	nsubjpass	_	_
25	between	between	IN	IN	_	28	case	_	_
26	these	these	DT	DT	_	28	det	_	_
27	two	two	CD	CD	_	28	nummod	_	_
28	genes	gene	NNS	NNS	_	24	nmod	_	_
29	can	can	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	found	find	VBN	VBN	_	8	conj	_	_
32	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	human	human	JJ	JJ	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mouse	mouse	NN	NN	_	2	conj	_	_
5	GATA3	gata3	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	units	unit	NNS	NNS	_	2	dep	_	_
8	start	start	VBP	VBP	_	0	root	_	_
9	at	at	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	major	major	JJ	JJ	_	13	amod	_	_
12	initiation	initiation	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	promoter	promoter	NN	NN	_	4	compound	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	genes	gene	NNS	NNS	_	4	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	they	they	PRP	PRP	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	embedded	embedded	JJ	JJ	_	9	ccomp	_	_
14	within	within	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	CpG	cpg	NN	NN	_	17	compound	_	_
17	island	island	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	share	share	VBP	VBP	_	13	conj	_	_
20	structural	structural	JJ	JJ	_	21	amod	_	_
21	features	feature	NNS	NNS	_	19	dobj	_	_
22	often	often	RB	RB	_	21	advmod	_	_
23	found	find	VBN	VBN	_	21	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	promoters	promoter	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	housekeeping	housekeeping	JJ	JJ	_	29	amod	_	_
29	genes	gene	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	32	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	fragment	fragment	NN	NN	_	32	nsubj	_	_
9	containing	contain	VBG	VBG	_	8	acl	_	_
10	the	the	DT	DT	_	14	det	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	GATA3	gata3	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	unit	unit	NN	NN	_	9	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	3	3	CD	CD	_	17	nummod	_	_
17	kb	kb	NN	NN	_	18	nmod:npmod	_	_
18	upstream	upstream	RB	RB	_	23	advmod	_	_
19	from	from	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	initiation	initiation	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	14	advmod	_	_
24	4	4	CD	CD	_	25	nummod	_	_
25	kb	kb	NN	NN	_	23	advmod	_	_
26	downstream	downstream	RB	RB	_	25	advmod	_	_
27	from	from	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	polyadenylation	polyadenylation	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	25	nmod	_	_
31	,	,	,	,	_	8	punct	_	_
32	displays	display	VBZ	VBZ	_	4	ccomp	_	_
33	T-cell	t-cell	NN	NN	_	34	compound	_	_
34	specificity	specificity	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	4	punct	_	_

1	Mechanisms	mechanism	NNS	NNS	_	0	root	_	_
2	involved	involve	VBN	VBN	_	1	acl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	inhibition	inhibition	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	growth	growth	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	lymphoma	lymphoma	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	7	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	B104	b104	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	5	punct	_	_
18	by	by	IN	IN	_	22	case	_	_
19	anti-MHC	anti-mhc	JJ	JJ	_	22	amod	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	antibodies	antibody	NNS	NNS	_	5	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	28	nsubjpass	_	_
3	involved	involve	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inhibition	inhibition	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	growth	growth	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	15	case	_	_
10	a	a	DT	DT	_	15	det	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	B	b	NN	NN	_	15	compound	_	_
13	lymphoma	lymphoma	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	B104	b104	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	6	punct	_	_
19	by	by	IN	IN	_	23	case	_	_
20	anti-MHC	anti-mhc	JJ	JJ	_	23	amod	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	23	nummod	_	_
23	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	Ab	ab	NNS	NNS	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	compared	compare	VBN	VBN	_	0	root	_	_
29	with	with	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	28	nmod	_	_
31	in	in	IN	IN	_	36	case	_	_
32	anti-IgM	anti-igm	JJ	JJ	_	36	amod	_	_
33	Ab-induced	ab-induced	JJ	JJ	_	36	amod	_	_
34	B104	b104	NN	NN	_	36	compound	_	_
35	growth	growth	NN	NN	_	36	compound	_	_
36	inhibition	inhibition	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	28	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	anti-MHC	anti-mhc	JJ	JJ	_	5	amod	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	Ab	ab	NNS	NNS	_	11	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	L227	l227	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	2.06	2.06	CD	CD	_	7	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	growth	growth	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	B104	b104	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	although	although	IN	IN	_	25	mark	_	_
19	2.06	2.06	CD	CD	_	25	nsubj	_	_
20	,	,	,	,	_	19	punct	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	19	cc	_	_
23	L227	l227	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	needed	need	VBD	VBD	_	11	advcl	_	_
26	to	to	TO	TO	_	29	mark	_	_
27	be	be	VB	VB	_	29	auxpass	_	_
28	further	further	RBR	RBR	_	29	advmod	_	_
29	cross-linked	cross-link	VBN	VBN	_	25	xcomp	_	_
30	with	with	IN	IN	_	35	case	_	_
31	a	a	DT	DT	_	35	det	_	_
32	goat	goat	NN	NN	_	35	compound	_	_
33	anti-mouse	anti-mouse	JJ	JJ	_	35	amod	_	_
34	IgG	igg	NN	NN	_	35	compound	_	_
35	Ab	ab	NN	NN	_	29	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	GAM	gam	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	to	to	TO	TO	_	40	mark	_	_
40	show	show	VB	VB	_	25	xcomp	_	_
41	the	the	DT	DT	_	42	det	_	_
42	effect	effect	NN	NN	_	40	dobj	_	_
43	.	.	.	.	_	11	punct	_	_

1	L227	l227	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
7	free	free	JJ	JJ	_	6	dep	_	_
8	Ca2+	ca2+	NN	NN	_	9	compound	_	_
9	concentration	concentration	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	pool	pool	NN	NN	_	4	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	little	little	JJ	JJ	_	4	conj	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	no	no	DT	DT	_	18	conj	_	_
21	protein	protein	NN	NN	_	23	compound	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	18	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	phosphatidyl	phosphatidyl	JJ	JJ	_	27	amod	_	_
26	inositol	inositol	NN	NN	_	27	compound	_	_
27	turnover	turnover	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	or	or	CC	CC	_	23	cc	_	_
30	expression	expression	NN	NN	_	23	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	Egr-1	egr-1	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	30	nmod	_	_
34	,	,	,	,	_	2	punct	_	_
35	whereas	whereas	IN	IN	_	39	mark	_	_
36	2.06	2.06	CD	CD	_	39	nsubj	_	_
37	plus	plus	CC	CC	_	36	cc	_	_
38	GAM	gam	NN	NN	_	36	conj	_	_
39	induced	induce	VBD	VBD	_	2	advcl	_	_
40	an	a	DT	DT	_	41	det	_	_
41	increase	increase	NN	NN	_	39	dobj	_	_
42	in	in	IN	IN	_	43	case	_	_
43	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	41	nmod	_	_
44	from	from	IN	IN	_	47	case	_	_
45	both	both	CC	CC	_	47	cc:preconj	_	_
46	the	the	DT	DT	_	47	det	_	_
47	intracellular	intracellular	JJ	JJ	_	41	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	,	,	,	,	_	47	punct	_	_
50	in	in	IN	IN	_	51	case	_	_
51	particular	particular	JJ	JJ	_	47	conj	_	_
52	,	,	,	,	_	47	punct	_	_
53	the	the	DT	DT	_	54	det	_	_
54	extracellular	extracellular	JJ	JJ	_	47	conj	_	_
55	pools	pool	NNS	NNS	_	47	dep	_	_
56	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	B104	b104	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	growth	growth	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	12	case	_	_
9	anti-MHC	anti-mhc	JJ	JJ	_	12	amod	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	Ab	ab	NNS	NNS	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	Ca(2+)-independent	ca(2+)-independent	JJ	JJ	_	0	root	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	14	conj	_	_
17	inhibited	inhibit	VBN	VBN	_	14	dep	_	_
18	by	by	IN	IN	_	20	case	_	_
19	actinomycin	actinomycin	JJ	JJ	_	20	amod	_	_
20	D	d	NN	NN	_	17	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	cyclosporin	cyclosporin	NN	NN	_	23	compound	_	_
23	A	a	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	cycle	cycle	NN	NN	_	28	compound	_	_
28	arrest	arrest	NN	NN	_	35	nsubjpass	_	_
29	at	at	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	G2/M	g2/m	NN	NN	_	32	compound	_	_
32	interphase	interphase	NN	NN	_	28	nmod	_	_
33	was	be	VBD	VBD	_	35	auxpass	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	observed	observe	VBN	VBN	_	14	conj	_	_
36	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	features	feature	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	very	very	RB	RB	_	5	advmod	_	_
5	different	different	JJ	JJ	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	those	those	DT	DT	_	5	nmod	_	_
8	observed	observe	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	B104	b104	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	death	death	NN	NN	_	8	nmod	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	anti-IgM	anti-igm	JJ	JJ	_	16	amod	_	_
16	Ab	ab	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Neither	neither	DT	DT	_	3	cc:preconj	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	fragmentation	fragmentation	NN	NN	_	10	nsubjpass	_	_
4	nor	nor	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	6	det	_	_
6	morphology	morphology	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	cross-linking	cross-linking	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	MHC	mhc	NN	NN	_	10	compound	_	_
8	class	class	NN	NN	_	10	compound	_	_
9	II	ii	CD	CD	_	10	nummod	_	_
10	molecules	molecule	NNS	NNS	_	5	nmod	_	_
11	transduced	transduce	VBD	VBD	_	3	ccomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	negative	negative	JJ	JJ	_	14	amod	_	_
14	signals	signal	NNS	NNS	_	11	dobj	_	_
15	through	through	IN	IN	_	17	case	_	_
16	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
17	mechanisms	mechanism	NNS	NNS	_	11	nmod	_	_
18	different	different	JJ	JJ	_	17	amod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	those	those	DT	DT	_	18	nmod	_	_
21	present	present	JJ	JJ	_	20	amod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cross-linking	cross-linking	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	surface	surface	NN	NN	_	27	compound	_	_
27	IgM	igm	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CD14	cd14	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	during	during	IN	IN	_	7	case	_	_
6	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	1	nmod	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	1	1	CD	CD	_	12	nummod	_	_
11	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	12	compound	_	_
12	D3	d3	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	CD14	cd14	NN	NN	_	19	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	monocyte/macrophage	monocyte/macrophage	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	appos	_	_
6	for	for	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	complex	complex	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	LPS	lps	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	LPS	lps	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	1	punct	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	differentiation	differentiation	NN	NN	_	19	compound	_	_
19	marker	marker	NN	NN	_	0	root	_	_
20	for	for	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	monocyte/macrophage	monocyte/macrophage	NN	NN	_	23	compound	_	_
23	lineage	lineage	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	CD14	cd14	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	during	during	IN	IN	_	18	case	_	_
10	1	1	CD	CD	_	18	nummod	_	_
11	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	18	compound	_	_
12	D3	d3	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	VitD3	vitd3	NN	NN	_	18	compound	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	-induced	-induced	JJ	JJ	_	18	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	5	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	FACS	facs	NN	NN	_	1	dobj	_	_
3	,	,	,	,	_	2	punct	_	_
4	Northern	northern	NN	NN	_	5	compound	_	_
5	blotting	blotting	NN	NN	_	2	conj	_	_
6	,	,	,	,	_	2	punct	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	run-on	run-on	JJ	JJ	_	2	conj	_	_
10	analyses	analysis	NNS	NNS	_	2	dep	_	_
11	,	,	,	,	_	1	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
14	that	that	IN	IN	_	25	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	up-regulation	up-regulation	NN	NN	_	25	nsubjpass	_	_
17	of	of	IN	IN	_	19	case	_	_
18	CD14	cd14	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	during	during	IN	IN	_	23	case	_	_
21	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	maturation	maturation	NN	NN	_	16	nmod	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	regulated	regulate	VBN	VBN	_	13	ccomp	_	_
26	mainly	mainly	RB	RB	_	25	advmod	_	_
27	at	at	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	level	level	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	transcription	transcription	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	25	punct	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	that	that	IN	IN	_	40	mark	_	_
36	new	new	JJ	JJ	_	38	amod	_	_
37	protein	protein	NN	NN	_	38	compound	_	_
38	synthesis	synthesis	NN	NN	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	required	require	VBN	VBN	_	25	conj	_	_
41	for	for	IN	IN	_	43	case	_	_
42	CD14	cd14	NN	NN	_	43	compound	_	_
43	induction	induction	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	cloned	clone	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	9	det	_	_
6	CD14	cd14	NN	NN	_	9	compound	_	_
7	5'	5'	JJ	JJ	_	9	amod	_	_
8	upstream	upstream	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	4	dobj	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	demonstrated	demonstrate	VBD	VBD	_	4	conj	_	_
12	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	15	amod	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	stable	stable	JJ	JJ	_	3	amod	_	_
3	transfection	transfection	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	monocytoid	monocytoid	JJ	JJ	_	9	amod	_	_
7	U937	u937	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	3	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	series	series	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	deletion	deletion	NN	NN	_	15	compound	_	_
15	mutants	mutant	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	CD14	cd14	NN	NN	_	21	compound	_	_
19	5'	5'	JJ	JJ	_	21	amod	_	_
20	upstream	upstream	JJ	JJ	_	21	amod	_	_
21	sequence	sequence	NN	NN	_	15	nmod	_	_
22	coupled	couple	VBN	VBN	_	21	acl	_	_
23	to	to	TO	TO	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	reporter	reporter	NN	NN	_	27	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	construct	construct	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	1	punct	_	_
29	we	we	PRP	PRP	_	30	nsubj	_	_
30	show	show	VBP	VBP	_	1	parataxis	_	_
31	that	that	IN	IN	_	39	mark	_	_
32	bp	bp	NN	NN	_	39	nsubj	_	_
33	-128	-128	CD	CD	_	32	nummod	_	_
34	to	to	TO	TO	_	32	dep	_	_
35	-70	-70	CD	CD	_	32	nummod	_	_
36	is	be	VBZ	VBZ	_	39	cop	_	_
37	the	the	DT	DT	_	39	det	_	_
38	critical	critical	JJ	JJ	_	39	amod	_	_
39	region	region	NN	NN	_	30	ccomp	_	_
40	for	for	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	induction	induction	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	CD14	cd14	NN	NN	_	45	compound	_	_
45	expression	expression	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sites	site	NNS	NNS	_	3	dobj	_	_
7	for	for	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	Sp1	sp1	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	3-bp	3-bp	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	11	nsubj	_	_
4	at	at	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	distal	distal	JJ	JJ	_	8	amod	_	_
7	Sp1-binding	sp1-binding	JJ	JJ	_	8	amod	_	_
8	site	site	NN	NN	_	3	nmod	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	11	cc:preconj	_	_
11	eliminates	eliminate	VBZ	VBZ	_	0	root	_	_
12	Sp1	sp1	NN	NN	_	13	compound	_	_
13	interaction	interaction	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	11	punct	_	_
15	but	but	CC	CC	_	11	cc	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	abolishes	abolish	VBZ	VBZ	_	11	conj	_	_
18	most	most	JJS	JJS	_	17	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	VitD3	vitd3	NN	NN	_	22	compound	_	_
22	induction	induction	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	CD14	cd14	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	7	nsubj	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	detect	detect	VB	VB	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	direct	direct	JJ	JJ	_	10	amod	_	_
10	interaction	interaction	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	CD14	cd14	NN	NN	_	16	compound	_	_
14	distal	distal	JJ	JJ	_	16	amod	_	_
15	Sp1-binding	sp1-binding	JJ	JJ	_	16	amod	_	_
16	site	site	NN	NN	_	10	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	vitamin	vitamin	NN	NN	_	21	compound	_	_
20	D3	d3	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	10	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	partner	partner	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	24	punct	_	_
26	the	the	DT	DT	_	29	det	_	_
27	retinoid	retinoid	NN	NN	_	29	compound	_	_
28	X	x	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	24	appos	_	_
30	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	VitD3	vitd3	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	CD14	cd14	NN	NN	_	6	dobj	_	_
8	indirectly	indirectly	RB	RB	_	6	advmod	_	_
9	through	through	IN	IN	_	12	case	_	_
10	some	some	DT	DT	_	12	det	_	_
11	intermediary	intermediary	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	suggest	suggest	VBP	VBP	_	3	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	15	dobj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	Sp1	sp1	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	process	process	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Calcium	calcium	NN	NN	_	2	compound	_	_
2	signalling	signalling	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	stimulated	stimulate	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	cyclophilin	cyclophilin	NN	NN	_	11	compound	_	_
10	B-binding	b-binding	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunosuppressant	immunosuppressant	JJ	JJ	_	3	amod	_	_
3	drug	drug	NN	NN	_	6	nsubj	_	_
4	cyclosporin	cyclosporin	NN	NN	_	5	compound	_	_
5	A	a	NN	NN	_	3	dep	_	_
6	blocks	block	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	calcium-dependent	calcium-dependent	JJ	JJ	_	9	amod	_	_
9	signal	signal	NN	NN	_	6	dobj	_	_
10	from	from	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TCR	tcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	normally	normally	RB	RB	_	19	advmod	_	_
19	leads	lead	VBZ	VBZ	_	9	acl:relcl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	bound	bind	VBN	VBN	_	8	advcl	_	_
3	to	to	TO	TO	_	4	case	_	_
4	cyclophilin	cyclophilin	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	cyclosporin	cyclosporin	NN	NN	_	7	compound	_	_
7	A	a	NN	NN	_	8	nsubj	_	_
8	binds	bind	VBZ	VBZ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	inactivates	inactivate	VBZ	VBZ	_	8	conj	_	_
11	the	the	DT	DT	_	15	det	_	_
12	key	key	JJ	JJ	_	15	amod	_	_
13	signalling	signalling	NN	NN	_	15	compound	_	_
14	intermediate	intermediate	JJ	JJ	_	15	amod	_	_
15	calcineurin	calcineurin	NN	NN	_	8	dobj	_	_
16	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	potential	potential	JJ	JJ	_	5	amod	_	_
4	cellular	cellular	JJ	JJ	_	3	dep	_	_
5	homologues	homologue	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cyclosporin	cyclosporin	NN	NN	_	8	compound	_	_
8	A	a	NN	NN	_	5	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	might	might	MD	MD	_	11	aux	_	_
11	regulate	regulate	VB	VB	_	5	acl:relcl	_	_
12	calcium	calcium	NN	NN	_	13	compound	_	_
13	signalling	signalling	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	2	punct	_	_
15	we	we	PRP	PRP	_	17	nsubj	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	cloned	clone	VBN	VBN	_	2	parataxis	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	17	dobj	_	_
20	encoding	encode	VBG	VBG	_	19	acl	_	_
21	cyclophilin	cyclophilin	NN	NN	_	22	compound	_	_
22	B-binding-proteins	b-binding-protein	NNS	NNS	_	20	dobj	_	_
23	using	use	VBG	VBG	_	17	xcomp	_	_
24	the	the	DT	DT	_	27	det	_	_
25	yeast	yeast	NN	NN	_	27	compound	_	_
26	two-hybrid	two-hybrid	JJ	JJ	_	27	amod	_	_
27	system	system	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	2	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	product	product	NN	NN	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	when	when	WRB	WRB	_	6	advmod	_	_
6	overexpressed	overexpress	VBN	VBN	_	13	advcl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	Jurkat	jurkat	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	specifically	specifically	RB	RB	_	13	advmod	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	interleukin-2	interleukin-2	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	activating	activate	VBG	VBG	_	13	advcl	_	_
22	the	the	DT	DT	_	25	det	_	_
23	T-cell-specific	t-cell-specific	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	dobj	_	_
26	NF-AT	nf-at	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	NF-IL2A	nf-il2a	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	termed	term	VBN	VBN	_	2	acl	_	_
5	calcium-signal	calcium-signal	JJ	JJ	_	8	amod	_	_
6	modulating	modulating	NN	NN	_	8	compound	_	_
7	cyclophilin	cyclophilin	NN	NN	_	8	compound	_	_
8	ligand	ligand	NN	NN	_	4	xcomp	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CAML	caml	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	2	punct	_	_
13	acts	act	VBZ	VBZ	_	0	root	_	_
14	downstream	downstream	RB	RB	_	18	advmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	TCR	tcr	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	13	advmod	_	_
19	upstream	upstream	RB	RB	_	18	advmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	calcineurin	calcineurin	NN	NN	_	19	nmod	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	causing	cause	VBG	VBG	_	13	advcl	_	_
24	an	a	DT	DT	_	25	det	_	_
25	influx	influx	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	calcium	calcium	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	CAML	caml	NN	NN	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	7	mark	_	_
4	be	be	VB	VB	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	participant	participant	NN	NN	_	2	xcomp	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	calcium-signal	calcium-signal	JJ	JJ	_	12	amod	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	implicating	implicate	VBG	VBG	_	2	xcomp	_	_
15	cyclophilin	cyclophilin	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	calcium	calcium	NN	NN	_	19	compound	_	_
19	signalling	signalling	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	even	even	RB	RB	_	24	advmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	absence	absence	NN	NN	_	14	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	cyclosporin	cyclosporin	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
4	Nef	nef	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	activation	activation	NN	NN	_	8	compound	_	_
8	pathways	pathway	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	12	case	_	_
4	the	the	DT	DT	_	12	det	_	_
5	human	human	JJ	JJ	_	12	amod	_	_
6	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
7	virus	virus	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	Nef	nef	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	2	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	activation	activation	NN	NN	_	17	compound	_	_
17	pathways	pathway	NNS	NNS	_	2	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	investigated	investigate	VBN	VBN	_	0	root	_	_
20	using	use	VBG	VBG	_	19	xcomp	_	_
21	a	a	DT	DT	_	25	det	_	_
22	Jurkat	jurkat	NN	NN	_	25	compound	_	_
23	CD4+	cd4+	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	20	dobj	_	_
26	stably	stably	RB	RB	_	27	advmod	_	_
27	transfected	transfect	VBN	VBN	_	25	acl	_	_
28	with	with	IN	IN	_	32	case	_	_
29	a	a	DT	DT	_	32	det	_	_
30	Nef	nef	NN	NN	_	32	compound	_	_
31	expression	expression	NN	NN	_	32	compound	_	_
32	vector	vector	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	Secretion	secretion	NN	NN	_	39	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	TNF-alpha	tnf-alpha	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	1	punct	_	_
7	surface	surface	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IL-2R	il-2r	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	and	and	CC	CC	_	1	cc	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	1	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	AP-1	ap-1	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	Fos/Jun	fos/jun	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	complex	complex	NN	NN	_	17	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	response	response	NN	NN	_	14	nmod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	myristate	myristate	NN	NN	_	29	compound	_	_
29	acetate	acetate	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	TNF-alpha	tnf-alpha	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	29	punct	_	_
33	or	or	CC	CC	_	29	cc	_	_
34	immobilized	immobilize	VBN	VBN	_	35	amod	_	_
35	antibodies	antibody	NNS	NNS	_	29	conj	_	_
36	to	to	TO	TO	_	37	case	_	_
37	CD3	cd3	NN	NN	_	35	nmod	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	monitored	monitor	VBN	VBN	_	0	root	_	_
40	.	.	.	.	_	39	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	parameters	parameter	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	modified	modify	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	Nef	nef	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	whereas	whereas	IN	IN	_	19	mark	_	_
14	stimulation	stimulation	NN	NN	_	19	nsubj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	same	same	JJ	JJ	_	18	amod	_	_
18	stimuli	stimulus	NNS	NNS	_	14	nmod	_	_
19	resulted	result	VBD	VBD	_	5	advcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	partial	partial	JJ	JJ	_	22	amod	_	_
22	inhibition	inhibition	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	LTR	ltr	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	Nef+	nef+	JJ	JJ	_	29	amod	_	_
28	Jurkat	jurkat	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	mediated	mediate	VBN	VBN	_	0	root	_	_
6	through	through	IN	IN	_	8	case	_	_
7	Nef	nef	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
9	on	on	IN	IN	_	10	case	_	_
10	Thr-15	thr-15	NN	NN	_	5	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	GTP-binding	gtp-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	conj	_	_
14	because	because	IN	IN	_	21	mark	_	_
15	mutations	mutation	NNS	NNS	_	21	nsubj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	sites	site	NNS	NNS	_	15	nmod	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	alter	alter	VB	VB	_	5	advcl	_	_
22	this	this	DT	DT	_	23	det	_	_
23	inhibition	inhibition	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	truncated	truncate	VBN	VBN	_	4	amod	_	_
4	LTRs	ltr	NNS	NNS	_	1	nmod	_	_
5	confirmed	confirm	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	inhibition	inhibition	NN	NN	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	LTR	ltr	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	mediated	mediate	VBN	VBN	_	5	ccomp	_	_
14	through	through	IN	IN	_	17	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B-binding	b-binding	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	17	cc	_	_
19	through	through	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	region	region	NN	NN	_	17	conj	_	_
22	containing	contain	VBG	VBG	_	21	acl	_	_
23	the	the	DT	DT	_	26	det	_	_
24	negative	negative	JJ	JJ	_	26	amod	_	_
25	responding	respond	VBG	VBG	_	26	amod	_	_
26	elements	element	NNS	NNS	_	22	dobj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	NREs	nre	NNS	NNS	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Nef	nef	NN	NN	_	6	nsubj	_	_
6	downmodulates	downmodulate	VBZ	VBZ	_	3	ccomp	_	_
7	LTR	ltr	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	without	without	IN	IN	_	11	mark	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	capacity	capacity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	respond	respond	VB	VB	_	13	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	immunological	immunological	JJ	JJ	_	21	amod	_	_
21	activations	activation	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Marked	marked	JJ	JJ	_	2	amod	_	_
2	basophilia	basophilia	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	acute	acute	JJ	JJ	_	6	amod	_	_
5	promyelocytic	promyelocytic	JJ	JJ	_	6	amod	_	_
6	leukaemia	leukaemia	NN	NN	_	2	nmod	_	_
7	treated	treat	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	all-trans	all-trans	JJ	JJ	_	10	amod	_	_
10	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
11	acid	acid	NN	NN	_	7	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	analysis	analysis	NN	NN	_	2	dep	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	origin	origin	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	basophils	basophil	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	patient	patient	NN	NN	_	2	dobj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	promyelocytic	promyelocytic	JJ	JJ	_	8	amod	_	_
8	leukaemia	leukaemia	NN	NN	_	4	nmod	_	_
9	who	who	WP	WP	_	10	nsubj	_	_
10	developed	develop	VBD	VBD	_	4	acl:relcl	_	_
11	marked	marked	JJ	JJ	_	12	amod	_	_
12	basophilia	basophilia	NN	NN	_	10	dobj	_	_
13	during	during	IN	IN	_	17	case	_	_
14	all-trans	all-trans	JJ	JJ	_	17	amod	_	_
15	retinoic	retinoic	JJ	JJ	_	17	amod	_	_
16	acid	acid	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	genomic	genomic	JJ	JJ	_	4	amod	_	_
4	DNA	dna	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	RNA	rna	NN	NN	_	4	conj	_	_
7	extracted	extract	VBN	VBN	_	4	acl	_	_
8	from	from	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	patient	patient	NN	NN	_	13	nmod:poss	_	_
11	's	's	POS	POS	_	13	case	_	_
12	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
13	leucocytes	leucocyte	NNS	NNS	_	7	nmod	_	_
14	in	in	IN	IN	_	17	mark	_	_
15	order	order	NN	NN	_	14	mwe	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	determine	determine	VB	VB	_	2	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	origin	origin	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	basophils	basophil	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	RAR	rar	NN	NN	_	5	compound	_	_
3	alpha	alpha	NN	NN	_	5	compound	_	_
4	rearranged	rearranged	JJ	JJ	_	5	amod	_	_
5	band	band	NN	NN	_	24	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	Southern	southern	NN	NN	_	10	compound	_	_
9	blot	blot	NN	NN	_	10	compound	_	_
10	analysis	analysis	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	a	a	DT	DT	_	14	det	_	_
13	chimaeric	chimaeric	JJ	JJ	_	14	amod	_	_
14	product	product	NN	NN	_	5	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	PML-RAR	pml-rar	JJ	JJ	_	17	amod	_	_
17	alpha	alpha	NN	NN	_	14	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	polymerase	polymerase	NN	NN	_	21	compound	_	_
20	chain	chain	NN	NN	_	21	compound	_	_
21	reaction	reaction	NN	NN	_	14	nmod	_	_
22	were	be	VBD	VBD	_	24	cop	_	_
23	strongly	strongly	RB	RB	_	24	advmod	_	_
24	visible	visible	JJ	JJ	_	0	root	_	_
25	before	before	IN	IN	_	27	case	_	_
26	ATRA	atra	NN	NN	_	27	compound	_	_
27	treatment	treatment	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	but	but	CC	CC	_	24	cc	_	_
30	at	at	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	time	time	NN	NN	_	41	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	maximal	maximal	JJ	JJ	_	35	amod	_	_
35	basophilia	basophilia	NN	NN	_	32	nmod	_	_
36	both	both	DT	DT	_	41	nsubjpass	_	_
37	of	of	IN	IN	_	38	case	_	_
38	them	they	PRP	PRP	_	36	nmod	_	_
39	were	be	VBD	VBD	_	41	auxpass	_	_
40	markedly	markedly	RB	RB	_	41	advmod	_	_
41	diminished	diminish	VBN	VBN	_	24	conj	_	_
42	.	.	.	.	_	24	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	basophils	basophil	NNS	NNS	_	14	nsubj	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	appeared	appear	VBD	VBD	_	6	acl:relcl	_	_
9	during	during	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ATRA	atra	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	8	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	reactive	reactive	JJ	JJ	_	3	ccomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	nature	nature	NN	NN	_	14	nmod	_	_
17	rather	rather	RB	RB	_	16	cc	_	_
18	than	than	IN	IN	_	17	mwe	_	_
19	a	a	DT	DT	_	21	det	_	_
20	leukaemic	leukaemic	JJ	JJ	_	21	amod	_	_
21	clone	clone	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Antioxidants	antioxidant	NNS	NNS	_	2	nsubj	_	_
2	inhibit	inhibit	VBP	VBP	_	0	root	_	_
3	monocyte	monocyte	NN	NN	_	4	compound	_	_
4	adhesion	adhesion	NN	NN	_	2	dobj	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	suppressing	suppress	VBG	VBG	_	2	advcl	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor-kappa	factor-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	mobilization	mobilization	NN	NN	_	6	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	induction	induction	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	vascular	vascular	JJ	JJ	_	17	amod	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	adhesion	adhesion	NN	NN	_	17	compound	_	_
17	molecule-1	molecule-1	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	12	nmod	_	_
21	stimulated	stimulate	VBN	VBN	_	20	acl	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	generate	generate	VB	VB	_	21	xcomp	_	_
24	radicals	radical	NNS	NNS	_	23	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	adhesion	adhesion	NN	NN	_	15	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	stimulated	stimulate	VBN	VBN	_	10	amod	_	_
7	by	by	IN	IN	_	10	amod	_	_
8	tumor	tumor	NN	NN	_	10	compound	_	_
9	necrosis	necrosis	NN	NN	_	10	compound	_	_
10	factor-alpha	factor-alpha	NN	NN	_	5	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TNF	tnf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	due	due	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	induction	induction	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	surface	surface	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	such	such	JJ	JJ	_	27	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	vascular	vascular	JJ	JJ	_	27	amod	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecule-1	molecule-1	NN	NN	_	20	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	VCAM-1	vcam-1	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	antioxidant	antioxidant	JJ	JJ	_	4	amod	_	_
3	pyrrolidine	pyrrolidine	NN	NN	_	4	compound	_	_
4	dithiocarbamate	dithiocarbamate	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PDTC	pdtc	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
10	activation	activation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor-kappa	factor-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	motifs	motif	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	present	present	JJ	JJ	_	19	advcl	_	_
7	in	in	IN	IN	_	16	case	_	_
8	VCAM-1	vcam-1	NN	NN	_	16	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	intercellular	intercellular	JJ	JJ	_	8	conj	_	_
11	adhesion	adhesion	NN	NN	_	16	compound	_	_
12	molecule-1	molecule-1	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	ICAM-1	icam-1	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	promoters	promoter	NNS	NNS	_	6	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	used	use	VBD	VBD	_	0	root	_	_
20	PDTC	pdtc	NN	NN	_	19	dobj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	study	study	VB	VB	_	19	advcl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
25	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	VCAM-1	vcam-1	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	ICAM-1	icam-1	NN	NN	_	27	conj	_	_
30	induction	induction	NN	NN	_	27	dep	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	subsequent	subsequent	JJ	JJ	_	34	amod	_	_
33	monocyte	monocyte	NN	NN	_	34	compound	_	_
34	adhesion	adhesion	NN	NN	_	27	conj	_	_
35	in	in	IN	IN	_	41	case	_	_
36	TNF-treated	tnf-treated	JJ	JJ	_	41	amod	_	_
37	human	human	JJ	JJ	_	41	amod	_	_
38	umbilical	umbilical	JJ	JJ	_	41	amod	_	_
39	vein	vein	NN	NN	_	41	compound	_	_
40	endothelial	endothelial	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	34	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	HUVECs	huvec	NNS	NNS	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	19	punct	_	_

1	PDTC	pdtc	NN	NN	_	6	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	N-acetylcysteine	n-acetylcysteine	NN	NN	_	1	conj	_	_
4	dose	dose	NN	NN	_	1	dep	_	_
5	dependently	dependently	RB	RB	_	6	advmod	_	_
6	reduced	reduce	VBD	VBD	_	0	root	_	_
7	TNF-induced	tnf-induced	JJ	JJ	_	8	amod	_	_
8	VCAM-1	vcam-1	NN	NN	_	6	dobj	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	ICAM-1	icam-1	NN	NN	_	13	compound	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	21	punct	_	_
15	also	also	RB	RB	_	21	dep	_	_
16	in	in	IN	IN	_	21	case	_	_
17	human	human	JJ	JJ	_	21	amod	_	_
18	umbilical	umbilical	JJ	JJ	_	21	amod	_	_
19	arterial	arterial	JJ	JJ	_	21	amod	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	8	cc	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	8	conj	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	by	by	IN	IN	_	29	case	_	_
28	70	70	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	25	nmod	_	_
30	at	at	IN	IN	_	33	case	_	_
31	100	100	CD	CD	_	33	nummod	_	_
32	mumol/L	mumol/l	NN	NN	_	33	compound	_	_
33	PDTC	pdtc	NN	NN	_	29	nmod	_	_
34	)	)	-RRB-	-RRB-	_	29	punct	_	_
35	in	in	IN	IN	_	36	case	_	_
36	HUVECs	huvec	NNS	NNS	_	25	nmod	_	_
37	as	as	IN	IN	_	38	mark	_	_
38	assessed	assess	VBN	VBN	_	6	advcl	_	_
39	by	by	IN	IN	_	41	case	_	_
40	flow	flow	NN	NN	_	41	compound	_	_
41	cytometry	cytometry	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	polymerase	polymerase	NN	NN	_	45	compound	_	_
44	chain	chain	NN	NN	_	45	compound	_	_
45	reaction	reaction	NN	NN	_	41	conj	_	_
46	.	.	.	.	_	6	punct	_	_

1	Gel-shift	gel-shift	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	HUVECs	huvec	NNS	NNS	_	2	nmod	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	PDTC	pdtc	NN	NN	_	8	nsubj	_	_
8	prevented	prevent	VBD	VBD	_	5	ccomp	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	mobilization	mobilization	NN	NN	_	8	dobj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	TNF	tnf	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	only	only	RB	RB	_	19	advmod	_	_
18	VCAM-1	vcam-1	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	controlled	control	VBN	VBN	_	15	ccomp	_	_
22	by	by	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Since	since	IN	IN	_	3	mark	_	_
2	HUVECs	huvec	NNS	NNS	_	3	nsubj	_	_
3	released	release	VBD	VBD	_	18	advcl	_	_
4	superoxide	superoxide	NN	NN	_	5	compound	_	_
5	anions	anion	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	3	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	TNF	tnf	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	H2O2	h2o2	NN	NN	_	13	nsubj	_	_
13	induces	induce	VBZ	VBZ	_	3	conj	_	_
14	VCAM-1	vcam-1	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	18	punct	_	_
16	PDTC	pdtc	NN	NN	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	act	act	VB	VB	_	0	root	_	_
19	as	as	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	radical	radical	JJ	JJ	_	22	amod	_	_
22	scavenger	scavenger	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	ICAM-1	icam-1	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	unaffected	unaffected	JJ	JJ	_	20	advcl	_	_
6	,	,	,	,	_	20	punct	_	_
7	inhibitors	inhibitor	NNS	NNS	_	20	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NADPH	nadph	NN	NN	_	10	compound	_	_
10	oxidase	oxidase	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	apocynin	apocynin	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	cytochrome	cytochrome	NN	NN	_	16	compound	_	_
16	P-450	p-450	NN	NN	_	10	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	SKF525a	skf525a	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	suppressed	suppress	VBD	VBD	_	0	root	_	_
21	VCAM-1	vcam-1	NN	NN	_	22	compound	_	_
22	induction	induction	NN	NN	_	20	dobj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	TNF	tnf	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	20	punct	_	_
26	revealing	reveal	VBG	VBG	_	20	advcl	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	several	several	JJ	JJ	_	30	amod	_	_
29	radical-generating	radical-generating	JJ	JJ	_	30	amod	_	_
30	systems	system	NNS	NNS	_	32	nsubjpass	_	_
31	are	be	VBP	VBP	_	32	auxpass	_	_
32	involved	involve	VBN	VBN	_	26	ccomp	_	_
33	in	in	IN	IN	_	35	case	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	regulation	regulation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	20	punct	_	_

1	PDTC	pdtc	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	apocynin	apocynin	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	or	or	CC	CC	_	1	cc	_	_
6	SKF525a	skf525a	NN	NN	_	1	conj	_	_
7	decreased	decrease	VBD	VBD	_	0	root	_	_
8	adhesion	adhesion	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	TNF-treated	tnf-treat	VBN	VBN	_	15	amod	_	_
15	HUVECs	huvec	NNS	NNS	_	8	nmod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	by	by	IN	IN	_	19	case	_	_
18	75	75	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	7	dep	_	_
20	at	at	IN	IN	_	23	case	_	_
21	100	100	CD	CD	_	23	nummod	_	_
22	mumol/L	mumol/l	NN	NN	_	23	compound	_	_
23	PDTC	pdtc	NN	NN	_	19	nmod	_	_
24	)	)	-RRB-	-RRB-	_	19	punct	_	_
25	.	.	.	.	_	7	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubj	_	_
2	by	by	IN	IN	_	5	case	_	_
3	anti-VCAM-1	anti-vcam-1	JJ	JJ	_	5	amod	_	_
4	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	1	nmod	_	_
6	1G11	1g11	NN	NN	_	5	dep	_	_
7	indicated	indicate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	U937	u937	NN	NN	_	10	compound	_	_
10	adhesion	adhesion	NN	NN	_	13	nsubj	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	VCAM-1	vcam-1	NN	NN	_	13	nmod:npmod	_	_
13	dependent	dependent	JJ	JJ	_	7	ccomp	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	suppression	suppression	NN	NN	_	19	nsubj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	antioxidants	antioxidant	NNS	NNS	_	15	nmod	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	due	due	JJ	JJ	_	13	conj	_	_
20	to	to	TO	TO	_	23	case	_	_
21	reduced	reduce	VBN	VBN	_	23	amod	_	_
22	VCAM-1	vcam-1	NN	NN	_	23	compound	_	_
23	induction	induction	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	low	low	JJ	JJ	_	5	amod	_	_
3	NM23.H1	nm23.h1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	0	root	_	_
6	identifying	identify	VBG	VBG	_	5	acl	_	_
7	high	high	JJ	JJ	_	10	amod	_	_
8	malignancy	malignancy	NN	NN	_	10	compound	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	melanomas	melanoma	NNS	NNS	_	6	dobj	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NM23	nm23	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	proposed	propose	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	metastasis-suppressor	metastasis-suppressor	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	use	use	NN	NN	_	17	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	suggested	suggest	VBN	VBN	_	6	conj	_	_
18	as	as	IN	IN	_	20	case	_	_
19	prognostic	prognostic	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	NM23	nm23	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	system	system	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	murine	murine	NN	NN	_	11	compound	_	_
9	melanoma	melanoma	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	19	nmod	_	_
15	an	a	DT	DT	_	17	det	_	_
16	inverse	inverse	JJ	JJ	_	17	amod	_	_
17	relationship	relationship	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	6	acl:relcl	_	_
20	between	between	IN	IN	_	22	case	_	_
21	NM23	nm23	CD	CD	_	22	nummod	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	metastatic	metastatic	JJ	JJ	_	25	amod	_	_
25	ability	ability	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	a	a	DT	DT	_	6	det	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	malignant	malignant	JJ	JJ	_	6	amod	_	_
5	melanoma	melanoma	NN	NN	_	6	compound	_	_
6	study	study	NN	NN	_	10	nmod	_	_
7	NM23	nm23	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	14	mark	_	_
12	be	be	VB	VB	_	14	cop	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	lower	lower	JJR	JJR	_	10	xcomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	metastases	metastase	NNS	NNS	_	14	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	developed	develop	VBD	VBD	_	16	acl:relcl	_	_
19	less	less	JJR	JJR	_	21	advmod	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	24	24	CD	CD	_	22	nummod	_	_
22	months	month	NNS	NNS	_	18	nmod	_	_
23	after	after	IN	IN	_	22	case	_	_
24	diagnosis	diagnosis	NN	NN	_	22	dep	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	primary	primary	JJ	JJ	_	28	amod	_	_
28	tumours	tumour	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	paper	paper	NN	NN	_	4	nsubj	_	_
4	studies	study	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	NM23.H1	nm23.h1	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	6	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	derive	derive	VBP	VBP	_	13	acl:relcl	_	_
16	from	from	IN	IN	_	17	case	_	_
17	primary	primary	JJ	JJ	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	metastatic	metastatic	JJ	JJ	_	17	conj	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	malignant	malignant	JJ	JJ	_	22	amod	_	_
22	melanomas	melanoma	NNS	NNS	_	17	dep	_	_
23	in	in	IN	IN	_	24	case	_	_
24	relation	relation	NN	NN	_	4	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	staging	staging	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	infiltration	infiltration	NN	NN	_	29	compound	_	_
29	degree	degree	NN	NN	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	lymphocytic	lymphocytic	JJ	JJ	_	32	amod	_	_
32	infiltration	infiltration	NN	NN	_	26	conj	_	_
33	,	,	,	,	_	26	punct	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	morphology	morphology	NN	NN	_	26	conj	_	_
36	,	,	,	,	_	26	punct	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	pigmentation	pigmentation	NN	NN	_	26	conj	_	_
39	,	,	,	,	_	26	punct	_	_
40	karyotype	karyotype	NN	NN	_	26	conj	_	_
41	,	,	,	,	_	26	punct	_	_
42	and	and	CC	CC	_	26	cc	_	_
43	disease-free	disease-free	JJ	JJ	_	44	amod	_	_
44	survival	survival	NN	NN	_	26	conj	_	_
45	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	level	level	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	NM23	nm23	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	lower	lower	JJR	JJR	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	derive	derive	VBP	VBP	_	15	acl:relcl	_	_
18	from	from	IN	IN	_	22	case	_	_
19	more	more	JJR	JJR	_	20	dep	_	_
20	infiltrating	infiltrate	VBG	VBG	_	22	amod	_	_
21	primary	primary	JJ	JJ	_	22	amod	_	_
22	melanomas	melanoma	NNS	NNS	_	17	nmod	_	_
23	than	than	IN	IN	_	26	case	_	_
24	in	in	IN	IN	_	26	case	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	12	nmod	_	_
27	obtained	obtain	VBN	VBN	_	26	acl	_	_
28	from	from	IN	IN	_	31	case	_	_
29	less	less	RBR	RBR	_	30	advmod	_	_
30	infiltrating	infiltrating	JJ	JJ	_	31	amod	_	_
31	tumours	tumour	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Moreover	moreover	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	23	nsubj	_	_
5	derived	derive	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	7	case	_	_
7	tumours	tumour	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	disease-free	disease-free	JJ	JJ	_	13	amod	_	_
13	survival	survival	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	more	more	JJR	JJR	_	17	advmod	_	_
16	than	than	IN	IN	_	15	mwe	_	_
17	24	24	CD	CD	_	18	nummod	_	_
18	months	month	NNS	NNS	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	24-58	24-58	CD	CD	_	21	nummod	_	_
21	months	month	NNS	NNS	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	express	express	VBP	VBP	_	0	root	_	_
24	the	the	DT	DT	_	26	det	_	_
25	NM23	nm23	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	23	dobj	_	_
27	at	at	IN	IN	_	29	case	_	_
28	higher	higher	JJR	JJR	_	29	amod	_	_
29	levels	level	NNS	NNS	_	23	nmod	_	_
30	than	than	IN	IN	_	32	case	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	29	nmod	_	_
33	obtained	obtain	VBN	VBN	_	32	acl	_	_
34	from	from	IN	IN	_	35	case	_	_
35	melanomas	melanoma	NNS	NNS	_	33	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	patients	patient	NNS	NNS	_	35	nmod	_	_
38	with	with	IN	IN	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	disease-free	disease-free	JJ	JJ	_	41	amod	_	_
41	survival	survival	NN	NN	_	37	nmod	_	_
42	of	of	IN	IN	_	46	case	_	_
43	less	less	JJR	JJR	_	45	advmod	_	_
44	than	than	IN	IN	_	43	mwe	_	_
45	24	24	CD	CD	_	46	nummod	_	_
46	months	month	NNS	NNS	_	41	nmod	_	_
47	(	(	-LRB-	-LRB-	_	49	punct	_	_
48	6-15	6-15	CD	CD	_	49	nummod	_	_
49	months	month	NNS	NNS	_	46	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	.	.	.	.	_	23	punct	_	_

1	Novel	novel	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	aldosterone	aldosterone	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	:	:	:	:	_	3	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	50	50	CD	CD	_	12	compound	_	_
12	kDa	kda	NN	NN	_	13	amod	_	_
13	protein	protein	NN	NN	_	3	dep	_	_
14	on	on	IN	IN	_	15	case	_	_
15	SDS-PAGE	sds-page	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Fast	fast	JJ	JJ	_	4	amod	_	_
2	in	in	FW	FW	_	1	dep	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	effects	effect	NNS	NNS	_	28	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	aldosterone	aldosterone	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	Na+/H(+)-exchanger	na+/h(+)-exchanger	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	inositoltrisphosphate	inositoltrisphosphate	NN	NN	_	12	compound	_	_
12	generation	generation	NN	NN	_	4	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	corresponding	correspond	VBG	VBG	_	16	amod	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	binding	binding	NN	NN	_	12	conj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	plasma	plasma	NN	NN	_	19	compound	_	_
19	membranes	membrane	NNS	NNS	_	16	nmod	_	_
20	at	at	IN	IN	_	21	case	_	_
21	Kd-values	kd-value	NNS	NNS	_	12	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	approximately	approximately	RB	RB	_	24	advmod	_	_
24	0.1	0.1	CD	CD	_	25	nummod	_	_
25	nM	nm	NN	NN	_	21	nmod	_	_
26	have	have	VBP	VBP	_	28	aux	_	_
27	been	be	VBN	VBN	_	28	auxpass	_	_
28	found	find	VBN	VBN	_	0	root	_	_
29	in	in	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	mononuclear	mononuclear	JJ	JJ	_	32	amod	_	_
32	leukocytes	leukocyte	NNS	NNS	_	28	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	vascular	vascular	JJ	JJ	_	37	amod	_	_
35	smooth	smooth	JJ	JJ	_	37	amod	_	_
36	muscle	muscle	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	32	conj	_	_
38	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	aldosterone	aldosterone	NN	NN	_	5	compound	_	_
4	membrane	membrane	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	analyzed	analyze	VBN	VBN	_	0	root	_	_
8	on	on	IN	IN	_	9	case	_	_
9	SDS-PAGE	sds-page	NN	NN	_	7	nmod	_	_
10	after	after	IN	IN	_	11	case	_	_
11	labeling	label	VBG	VBG	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	microsomal	microsomal	JJ	JJ	_	14	amod	_	_
14	membranes	membrane	NNS	NNS	_	11	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	leukocytes	leukocyte	NNS	NNS	_	14	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	-LSB-125I-RSB--aldosterone-derivative	-lsb-125i-rsb--aldosterone-derivative	NN	NN	_	11	nmod	_	_
22	by	by	IN	IN	_	23	case	_	_
23	use	use	NN	NN	_	11	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	BASED	based	NN	NN	_	23	nmod	_	_
26	as	as	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	photoactivatable	photoactivatable	JJ	JJ	_	29	amod	_	_
29	crosslinker	crosslinker	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Binding	binding	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	1	1	CD	CD	_	4	compound	_	_
4	nM	nm	NN	NN	_	5	nummod	_	_
5	-LSB-125I-RSB--aldosterone	-lsb-125i-rsb--aldosterone	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	at	at	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	weight	weight	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	approximately	approximately	RB	RB	_	14	advmod	_	_
14	50	50	CD	CD	_	15	nummod	_	_
15	kDa	kda	NN	NN	_	11	nmod	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	absent	absent	JJ	JJ	_	11	acl:relcl	_	_
19	with	with	IN	IN	_	23	case	_	_
20	1	1	CD	CD	_	23	nummod	_	_
21	microM	microm	NN	NN	_	23	compound	_	_
22	cold	cold	JJ	JJ	_	23	amod	_	_
23	aldosterone	aldosterone	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	18	cc	_	_
27	cortisol	cortisol	NN	NN	_	18	conj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	binding	bind	VBG	VBG	_	31	amod	_	_
31	media	media	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	aldosterone-selectivity	aldosterone-selectivity	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	typical	typical	JJ	JJ	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	discriminatory	discriminatory	JJ	JJ	_	4	conj	_	_
7	for	for	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	new	new	JJ	JJ	_	12	amod	_	_
10	aldosterone	aldosterone	NN	NN	_	12	compound	_	_
11	membrane	membrane	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Solubilization	solubilization	NN	NN	_	23	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	membranes	membrane	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	high	high	JJ	JJ	_	11	amod	_	_
10	salt	salt	NN	NN	_	11	compound	_	_
11	concentrations	concentration	NNS	NNS	_	1	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	1	1	CD	CD	_	14	compound	_	_
14	M	m	NN	NN	_	15	amod	_	_
15	NaCl	nacl	NN	NN	_	11	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	1	1	CD	CD	_	18	compound	_	_
18	mM	mm	NN	NN	_	19	amod	_	_
19	EDTA	edta	NN	NN	_	15	appos	_	_
20	)	)	-RRB-	-RRB-	_	15	punct	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	achieved	achieve	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	It	it	PRP	PRP	_	5	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	thus	thus	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	appears	appear	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	integral	integral	JJ	JJ	_	10	amod	_	_
9	membrane	membrane	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Dithiothreitol	dithiothreitol	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	sulfhydryl	sulfhydryl	NN	NN	_	5	compound	_	_
5	agent	agent	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	reduce	reduce	VB	VB	_	0	root	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	aldosterone	aldosterone	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	dobj	_	_
13	indicating	indicate	VBG	VBG	_	9	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	absence	absence	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	SH-groups	sh-group	NNS	NNS	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	domain	domain	NN	NN	_	13	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	sensitive	sensitive	JJ	JJ	_	24	amod	_	_
24	structures	structure	NNS	NNS	_	21	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	receptors	receptor	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	characterize	characterize	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	novel	novel	JJ	JJ	_	11	amod	_	_
10	membrane	membrane	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	aldosterone	aldosterone	NN	NN	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	regard	regard	NN	NN	_	7	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	weight	weight	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	basic	basic	JJ	JJ	_	21	amod	_	_
21	properties	property	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	other	other	JJ	JJ	_	6	amod	_	_
5	related	related	JJ	JJ	_	6	amod	_	_
6	results	result	NNS	NNS	_	2	conj	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	reviewed	review	VBN	VBN	_	0	root	_	_
9	here	here	RB	RB	_	8	advmod	_	_
10	.	.	.	.	_	8	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	8	nsubj	_	_
3	from	from	IN	IN	_	7	case	_	_
4	renal	renal	JJ	JJ	_	7	amod	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	carcinoma	carcinoma	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	2	nmod	_	_
8	exhibit	exhibit	VBP	VBP	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	abnormal	abnormal	JJ	JJ	_	11	amod	_	_
11	pattern	pattern	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	kappa	kappa	NN	NN	_	16	compound	_	_
14	B-specific	b-specific	JJ	JJ	_	16	amod	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	11	nmod	_	_
17	:	:	:	:	_	8	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	preliminary	preliminary	JJ	JJ	_	20	amod	_	_
20	report	report	NN	NN	_	8	dep	_	_
21	.	.	.	.	_	8	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	poor	poor	JJ	JJ	_	7	amod	_	_
7	induction	induction	NN	NN	_	22	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	response	response	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	renal	renal	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	carcinoma	carcinoma	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	RCC	rcc	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	related	related	JJ	JJ	_	3	ccomp	_	_
23	to	to	TO	TO	_	24	case	_	_
24	alterations	alteration	NNS	NNS	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	signal	signal	NN	NN	_	28	compound	_	_
27	transduction	transduction	NN	NN	_	28	compound	_	_
28	pathways	pathway	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	9	nsubj	_	_
6	from	from	IN	IN	_	8	case	_	_
7	RCC	rcc	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	have	have	VBP	VBP	_	2	ccomp	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	alterations	alteration	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	kappa	kappa	NN	NN	_	17	compound	_	_
14	B	b	NN	NN	_	17	compound	_	_
15	motif-specific	motif-specific	JJ	JJ	_	17	amod	_	_
16	DNA-binding	dna-binding	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	alteration	alteration	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	substantial	substantial	JJ	JJ	_	12	amod	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B-binding	b-binding	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	7	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	which	which	WDT	WDT	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	observed	observe	VBN	VBN	_	7	acl:relcl	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	25	amod	_	_
23	mobility	mobility	NN	NN	_	25	compound	_	_
24	shift	shift	NN	NN	_	25	compound	_	_
25	assay	assay	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	kappa	kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	unstimulated	unstimulated	JJ	JJ	_	11	amod	_	_
9	patient	patient	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	similar	similar	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	that	that	DT	DT	_	13	nmod	_	_
16	observed	observe	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	from	from	IN	IN	_	22	case	_	_
21	normal	normal	JJ	JJ	_	22	amod	_	_
22	individuals	individual	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	26	nsubjpass	_	_
24	had	have	VBD	VBD	_	26	aux	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	activated	activate	VBN	VBN	_	19	acl:relcl	_	_
27	in	in	FW	FW	_	28	compound	_	_
28	vitro	vitro	FW	FW	_	26	advmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	29	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Western	western	NN	NN	_	7	compound	_	_
6	blotting	blotting	NN	NN	_	7	compound	_	_
7	experiments	experiment	NNS	NNS	_	3	nmod	_	_
8	using	use	VBG	VBG	_	7	acl	_	_
9	antibodies	antibody	NNS	NNS	_	8	dobj	_	_
10	to	to	TO	TO	_	14	case	_	_
11	kappa	kappa	NN	NN	_	14	compound	_	_
12	B/Rel	b/rel	NN	NN	_	14	compound	_	_
13	family	family	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	29	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B-binding	b-binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	29	nsubjpass	_	_
20	constitutively	constitutively	RB	RB	_	21	advmod	_	_
21	expressed	express	VBN	VBN	_	19	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	RCC	rcc	NN	NN	_	27	compound	_	_
27	patients	patient	NNS	NNS	_	24	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	composed	compose	VBN	VBN	_	0	root	_	_
30	mostly	mostly	RB	RB	_	29	advmod	_	_
31	of	of	IN	IN	_	38	case	_	_
32	the	the	DT	DT	_	38	det	_	_
33	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
34	B1	b1	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	38	punct	_	_
36	p50	p50	NN	NN	_	38	compound	_	_
37	)	)	-RRB-	-RRB-	_	38	punct	_	_
38	subunit	subunit	NN	NN	_	29	nmod	_	_
39	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	abnormality	abnormality	NN	NN	_	14	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B-binding	b-binding	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	patients	patient	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	0	root	_	_
15	that	that	IN	IN	_	37	mark	_	_
16	RelA	rela	NN	NN	_	37	nsubjpass	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	member	member	NN	NN	_	16	appos	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	Rel	rel	NN	NN	_	24	compound	_	_
23	homology	homology	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	19	nmod	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	part	part	NN	NN	_	19	acl:relcl	_	_
28	of	of	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	normal	normal	JJ	JJ	_	33	amod	_	_
31	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	27	nmod	_	_
34	,	,	,	,	_	16	punct	_	_
35	was	be	VBD	VBD	_	37	auxpass	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	induced	induce	VBN	VBN	_	14	ccomp	_	_
38	in	in	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	nucleus	nucleus	NN	NN	_	37	nmod	_	_
41	following	follow	VBG	VBG	_	42	case	_	_
42	activation	activation	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	14	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blotting	blotting	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	detect	detect	VB	VB	_	0	root	_	_
7	any	any	DT	DT	_	8	det	_	_
8	RelA	rela	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	extracts	extract	NNS	NNS	_	6	nmod	_	_
12	either	either	CC	CC	_	16	cc:preconj	_	_
13	before	before	IN	IN	_	16	nmod	_	_
14	or	or	CC	CC	_	16	cc	_	_
15	after	after	IN	IN	_	16	conj	_	_
16	stimulation	stimulation	NN	NN	_	6	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	altered	altered	JJ	JJ	_	5	amod	_	_
3	kappa	kappa	NN	NN	_	5	compound	_	_
4	B-binding	b-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	13	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	RCC	rcc	NN	NN	_	11	compound	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	impair	impair	VB	VB	_	0	root	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	capacity	capacity	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	respond	respond	VB	VB	_	15	acl	_	_
18	normally	normally	RB	RB	_	17	advmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	various	various	JJ	JJ	_	21	amod	_	_
21	stimuli	stimulus	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vivo	vivo	FW	FW	_	1	advmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	multiple	multiple	JJ	JJ	_	11	amod	_	_
11	phosphorylations	phosphorylation	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	intact	intact	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	2	nmod	_	_
15	is	be	VBZ	VBZ	_	19	aux	_	_
16	mechanistically	mechanistically	RB	RB	_	19	advmod	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	well	well	RB	RB	_	19	advmod	_	_
19	understood	understood	JJ	JJ	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	modifications	modification	NNS	NNS	_	3	dobj	_	_
6	imposed	impose	VBN	VBN	_	5	acl	_	_
7	on	on	IN	IN	_	12	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
9	B/I	b/i	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	components	component	NNS	NNS	_	6	nmod	_	_
13	following	follow	VBG	VBG	_	14	case	_	_
14	stimulation	stimulation	NN	NN	_	5	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	show	show	VBP	VBP	_	3	conj	_	_
17	that	that	IN	IN	_	27	mark	_	_
18	the	the	DT	DT	_	20	det	_	_
19	final	final	JJ	JJ	_	20	amod	_	_
20	step	step	NN	NN	_	27	nsubj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	induction	induction	NN	NN	_	20	nmod	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	20	advmod	_	_
27	involves	involve	VBZ	VBZ	_	16	ccomp	_	_
28	phosphorylation	phosphorylation	NN	NN	_	27	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	several	several	JJ	JJ	_	31	amod	_	_
31	members	member	NNS	NNS	_	28	nmod	_	_
32	of	of	IN	IN	_	39	case	_	_
33	the	the	DT	DT	_	39	det	_	_
34	NF-kappa	nf-kappa	NN	NN	_	39	compound	_	_
35	B/I	b/i	NN	NN	_	39	compound	_	_
36	kappa	kappa	NN	NN	_	39	compound	_	_
37	B	b	NN	NN	_	39	compound	_	_
38	protein	protein	NN	NN	_	39	compound	_	_
39	families	family	NNS	NNS	_	31	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	HeLa	hela	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	13	nmod	_	_
4	as	as	RB	RB	_	3	cc	_	_
5	well	well	RB	RB	_	4	mwe	_	_
6	as	as	IN	IN	_	4	mwe	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	conj	_	_
10	,	,	,	,	_	13	punct	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	13	nsubj	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	translocation	translocation	NN	NN	_	13	dobj	_	_
16	primarily	primarily	RB	RB	_	15	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	p50-p65	p50-p65	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	but	but	CC	CC	_	16	cc	_	_
21	not	not	RB	RB	_	23	neg	_	_
22	of	of	IN	IN	_	23	case	_	_
23	c-rel	c-rel	NN	NN	_	16	conj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	precursors	precursor	NNS	NNS	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	4	conj	_	_
10	became	become	VBD	VBD	_	0	root	_	_
11	strongly	strongly	RB	RB	_	10	advmod	_	_
12	phosphorylated	phosphorylate	VBN	VBN	_	10	xcomp	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	same	same	JJ	JJ	_	16	amod	_	_
16	kinetics	kinetics	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	inducible	inducible	JJ	JJ	_	6	amod	_	_
6	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
7	after	after	IN	IN	_	8	case	_	_
8	stimulation	stimulation	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	17	nsubj	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	constitutive	constitutive	JJ	JJ	_	16	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	13	dep	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	12	dobj	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	constitutively	constitutively	RB	RB	_	17	advmod	_	_
19	phosphorylated	phosphorylate	VBN	VBN	_	20	amod	_	_
20	p65	p65	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	I	i	NN	NN	_	25	compound	_	_
23	kappa	kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	17	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	accompanied	accompany	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	induced	induce	VBN	VBN	_	6	amod	_	_
6	processing	processing	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	precursors	precursor	NNS	NNS	_	6	nmod	_	_
10	p100	p100	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	p105	p105	NN	NN	_	9	conj	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	by	by	IN	IN	_	15	case	_	_
15	degradation	degradation	NN	NN	_	6	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	I	i	NN	NN	_	20	compound	_	_
18	kappa	kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	5	case	_	_
2	an	a	DT	DT	_	5	det	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	model	model	NN	NN	_	7	nmod	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	phosphorylation	phosphorylation	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	p105	p105	NN	NN	_	9	nmod	_	_
12	impedes	impede	VBZ	VBZ	_	7	ccomp	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	interact	interact	VB	VB	_	14	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	as	as	IN	IN	_	24	mark	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	shown	show	VBN	VBN	_	12	advcl	_	_
25	before	before	IN	IN	_	24	advmod	_	_
26	for	for	IN	IN	_	30	case	_	_
27	I	i	NN	NN	_	30	compound	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	alpha	alpha	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	even	even	RB	RB	_	4	advmod	_	_
4	p65	p65	NN	NN	_	11	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	c-rel	c-rel	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
12	after	after	IN	IN	_	13	case	_	_
13	induction	induction	NN	NN	_	11	nmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	11	advmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	21	nsubj	_	_
20	selectively	selectively	RB	RB	_	21	advmod	_	_
21	activates	activate	VBZ	VBZ	_	17	ccomp	_	_
22	only	only	RB	RB	_	26	advmod	_	_
23	specific	specific	JJ	JJ	_	26	amod	_	_
24	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	heteromers	heteromer	NNS	NNS	_	21	dobj	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	that	that	IN	IN	_	30	mark	_	_
29	modifications	modification	NNS	NNS	_	30	nsubj	_	_
30	regulate	regulate	VBP	VBP	_	21	conj	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	only	only	JJ	JJ	_	36	cc:preconj	_	_
33	I	i	NN	NN	_	36	compound	_	_
34	kappa	kappa	NN	NN	_	36	compound	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	molecules	molecule	NNS	NNS	_	30	dobj	_	_
37	but	but	CC	CC	_	36	cc	_	_
38	also	also	RB	RB	_	41	advmod	_	_
39	NF-kappa	nf-kappa	NN	NN	_	41	compound	_	_
40	B	b	NN	NN	_	41	compound	_	_
41	molecules	molecule	NNS	NNS	_	36	conj	_	_
42	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	cellular	cellular	JJ	JJ	_	7	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	phosphorylation-dependent	phosphorylation-dependent	JJ	JJ	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	14	det	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	20	nsubjpass	_	_
15	of	of	IN	IN	_	18	case	_	_
16	p65-containing	p65-containing	JJ	JJ	_	18	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	14	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	enhanced	enhance	VBN	VBN	_	9	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	phosphorylation	phosphorylation	NN	NN	_	20	nmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	20	advmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	31	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	31	nsubj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	hydrogen	hydrogen	NN	NN	_	10	compound	_	_
10	peroxide	peroxide	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	translocation	translocation	NN	NN	_	7	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	assumed	assume	VBN	VBN	_	7	acl:relcl	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	triggered	trigger	VBN	VBN	_	21	xcomp	_	_
25	by	by	IN	IN	_	28	case	_	_
26	reactive	reactive	JJ	JJ	_	28	amod	_	_
27	oxygen	oxygen	NN	NN	_	28	compound	_	_
28	intermediates	intermediate	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	7	punct	_	_
30	also	also	RB	RB	_	31	advmod	_	_
31	coincided	coincide	VBD	VBD	_	4	ccomp	_	_
32	with	with	IN	IN	_	33	case	_	_
33	incorporation	incorporation	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	phosphate	phosphate	NN	NN	_	33	nmod	_	_
36	into	into	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	same	same	JJ	JJ	_	39	amod	_	_
39	subunits	subunit	NNS	NNS	_	33	nmod	_	_
40	that	that	WDT	WDT	_	42	nsubjpass	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	modified	modify	VBN	VBN	_	39	acl:relcl	_	_
43	after	after	IN	IN	_	44	case	_	_
44	stimulation	stimulation	NN	NN	_	42	nmod	_	_
45	by	by	IN	IN	_	46	case	_	_
46	TNF-alpha	tnf-alpha	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	phosphorylation	phosphorylation	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	9	mark	_	_
6	be	be	VB	VB	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	general	general	JJ	JJ	_	9	amod	_	_
9	mechanism	mechanism	NN	NN	_	4	xcomp	_	_
10	for	for	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vivo	vivo	FW	FW	_	11	advmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	modification	modification	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	12	case	_	_
5	major	major	JJ	JJ	_	12	amod	_	_
6	histocompatibility	histocompatibility	NN	NN	_	12	compound	_	_
7	complex	complex	NN	NN	_	12	compound	_	_
8	class	class	NN	NN	_	12	compound	_	_
9	II	ii	CD	CD	_	12	nummod	_	_
10	DRA	dra	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	occupancy	occupancy	NN	NN	_	3	nmod	_	_
13	mediated	mediate	VBN	VBN	_	3	acl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	AIR-1	air-1	NN	NN	_	17	compound	_	_
17	trans-activator	trans-activator	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	RJ	rj	NN	NN	_	8	nsubj	_	_
2	2.2.5	2.2.5	CD	CD	_	1	nummod	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	a	a	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	mutant	mutant	NN	NN	_	0	root	_	_
9	derived	derive	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	Burkitt	burkitt	NN	NN	_	15	compound	_	_
13	lymphoma	lymphoma	NN	NN	_	15	compound	_	_
14	Raji	raji	NN	NN	_	15	compound	_	_
15	cell	cell	NN	NN	_	9	nmod	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	defective	defective	JJ	JJ	_	15	acl:relcl	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	AIR-1	air-1	NN	NN	_	23	compound	_	_
22	locus	locus	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	locus	locus	NN	NN	_	3	nsubj	_	_
3	encodes	encode	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	trans-activator	trans-activator	NN	NN	_	3	dobj	_	_
7	required	require	VBN	VBN	_	6	acl	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	constitutive	constitutive	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	21	case	_	_
13	major	major	JJ	JJ	_	21	amod	_	_
14	histocompatibility	histocompatibility	NN	NN	_	21	compound	_	_
15	complex	complex	NN	NN	_	21	compound	_	_
16	(	(	-LRB-	-LRB-	_	21	punct	_	_
17	MHC	mhc	NN	NN	_	21	compound	_	_
18	)	)	-RRB-	-RRB-	_	21	punct	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	genes	gene	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	by	by	IN	IN	_	10	case	_	_
6	in	in	FW	FW	_	10	amod	_	_
7	vivo	vivo	FW	FW	_	6	dep	_	_
8	DNase	dnase	NN	NN	_	10	compound	_	_
9	I	i	CD	CD	_	10	nummod	_	_
10	footprinting	footprinting	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	that	that	IN	IN	_	17	mark	_	_
13	the	the	DT	DT	_	16	det	_	_
14	AIR-1	air-1	NN	NN	_	16	compound	_	_
15	locus	locus	NN	NN	_	16	compound	_	_
16	defect	defect	NN	NN	_	17	nsubj	_	_
17	correlates	correlate	VBZ	VBZ	_	3	ccomp	_	_
18	with	with	IN	IN	_	19	case	_	_
19	changes	change	NNS	NNS	_	17	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	DRA	dra	NN	NN	_	24	compound	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	occupancy	occupancy	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	reexpression	reexpression	NN	NN	_	19	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	MHC	mhc	NN	NN	_	9	compound	_	_
7	class	class	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	genes	gene	NNS	NNS	_	3	nmod	_	_
10	in	in	IN	IN	_	17	case	_	_
11	RJ	rj	NN	NN	_	17	compound	_	_
12	2.2.5	2.2.5	CD	CD	_	17	nummod	_	_
13	x	x	NN	NN	_	17	compound	_	_
14	mouse	mouse	NN	NN	_	17	compound	_	_
15	spleen	spleen	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	hybrids	hybrid	NNS	NNS	_	3	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	associated	associate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	22	case	_	_
21	partial	partial	JJ	JJ	_	22	amod	_	_
22	reversion	reversion	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	DRA	dra	NN	NN	_	26	compound	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	occupancy	occupancy	NN	NN	_	22	nmod	_	_
27	to	to	TO	TO	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	Raji	raji	NN	NN	_	30	compound	_	_
30	pattern	pattern	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	DRA	dra	NN	NN	_	3	compound	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	occupancy	occupancy	NN	NN	_	22	nsubj	_	_
4	in	in	IN	IN	_	10	case	_	_
5	other	other	JJ	JJ	_	10	amod	_	_
6	class	class	NN	NN	_	10	compound	_	_
7	II-negative	ii-negative	JJ	JJ	_	10	amod	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	3	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	derived	derive	VBN	VBN	_	10	acl	_	_
13	from	from	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	bare	bare	JJ	JJ	_	18	amod	_	_
17	lymphocyte	lymphocyte	NN	NN	_	18	compound	_	_
18	syndrome	syndrome	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	drastically	drastically	RB	RB	_	22	advmod	_	_
22	different	different	JJ	JJ	_	0	root	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	one	one	NN	NN	_	22	nmod	_	_
26	observed	observe	VBN	VBN	_	25	acl	_	_
27	in	in	IN	IN	_	28	case	_	_
28	RJ	rj	NN	NN	_	26	nmod	_	_
29	2.2.5	2.2.5	CD	CD	_	28	nummod	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	Raji	raji	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	28	conj	_	_
33	.	.	.	.	_	22	punct	_	_

1	Moreover	moreover	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	use	use	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	DNase	dnase	NN	NN	_	4	nmod	_	_
8	I	i	CD	CD	_	7	nummod	_	_
9	as	as	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	in	in	FW	FW	_	14	amod	_	_
12	vivo	vivo	FW	FW	_	11	dep	_	_
13	footprinting	footprinting	NN	NN	_	14	compound	_	_
14	agent	agent	NN	NN	_	4	nmod	_	_
15	reveals	reveal	VBZ	VBZ	_	0	root	_	_
16	that	that	IN	IN	_	24	mark	_	_
17	the	the	DT	DT	_	21	det	_	_
18	patients	patient	NNS	NNS	_	21	nmod:poss	_	_
19	'	'	POS	POS	_	21	case	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	24	nsubj	_	_
22	do	do	VBP	VBP	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	display	display	VB	VB	_	15	ccomp	_	_
25	a	a	DT	DT	_	29	det	_	_
26	completely	completely	RB	RB	_	29	advmod	_	_
27	``	``	``	``	_	29	punct	_	_
28	bare	bare	JJ	JJ	_	29	amod	_	_
29	promoter	promoter	NN	NN	_	24	dobj	_	_
30	as	as	IN	IN	_	32	mark	_	_
31	previously	previously	RB	RB	_	32	advmod	_	_
32	reported	report	VBN	VBN	_	24	advcl	_	_
33	using	use	VBG	VBG	_	32	xcomp	_	_
34	dimethyl	dimethyl	JJ	JJ	_	35	amod	_	_
35	sulfate	sulfate	NN	NN	_	33	dobj	_	_
36	as	as	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	footprinting	footprinting	NN	NN	_	39	compound	_	_
39	agent	agent	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	15	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	use	use	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	DNase	dnase	NN	NN	_	4	nmod	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	allowed	allow	VBD	VBD	_	0	root	_	_
9	us	we	PRP	PRP	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	first	first	JJ	JJ	_	14	amod	_	_
14	time	time	NN	NN	_	17	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	correlate	correlate	VB	VB	_	8	xcomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	AIR-1	air-1	NN	NN	_	21	compound	_	_
20	locus	locus	NN	NN	_	21	compound	_	_
21	defect	defect	NN	NN	_	17	dobj	_	_
22	with	with	IN	IN	_	27	case	_	_
23	class	class	NN	NN	_	27	compound	_	_
24	II	ii	CD	CD	_	27	nummod	_	_
25	promoter	promoter	NN	NN	_	27	compound	_	_
26	occupancy	occupancy	NN	NN	_	27	compound	_	_
27	alterations	alteration	NNS	NNS	_	17	nmod	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	distinguish	distinguish	VB	VB	_	17	conj	_	_
30	these	these	DT	DT	_	31	det	_	_
31	alterations	alteration	NNS	NNS	_	29	dobj	_	_
32	from	from	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	ones	one	NNS	NNS	_	29	nmod	_	_
35	observed	observe	VBN	VBN	_	34	acl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	phenotypically	phenotypically	RB	RB	_	38	advmod	_	_
38	similar	similar	JJ	JJ	_	35	nmod	_	_
39	but	but	CC	CC	_	38	cc	_	_
40	genetically	genetically	RB	RB	_	41	advmod	_	_
41	distinct	distinct	JJ	JJ	_	38	conj	_	_
42	MHC	mhc	NN	NN	_	45	compound	_	_
43	class	class	NN	NN	_	45	compound	_	_
44	II-negative	ii-negative	JJ	JJ	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	38	dep	_	_
46	.	.	.	.	_	8	punct	_	_

1	Mechanism	mechanism	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	antiandrogen	antiandrogen	JJ	JJ	_	4	amod	_	_
4	action	action	NN	NN	_	1	nmod	_	_
5	:	:	:	:	_	1	punct	_	_
6	conformational	conformational	JJ	JJ	_	7	amod	_	_
7	changes	change	NNS	NNS	_	1	dep	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	receptor	receptor	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Androgen	androgen	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	translated	translate	VBN	VBN	_	0	root	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	5	advmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	androgen-	androgen-	NN	NN	_	16	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	antiandrogen-bound	antiandrogen-bound	JJ	JJ	_	10	conj	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	complexes	complex	NNS	NNS	_	10	dep	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	studied	study	VBN	VBN	_	5	conj	_	_
17	using	use	VBG	VBG	_	16	xcomp	_	_
18	limited	limited	JJ	JJ	_	20	amod	_	_
19	proteolytic	proteolytic	JJ	JJ	_	18	dep	_	_
20	digestion	digestion	NN	NN	_	17	dobj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	trypsin	trypsin	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Partial	partial	JJ	JJ	_	2	amod	_	_
2	proteolysis	proteolysis	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	androgen-bound	androgen-bound	JJ	JJ	_	6	amod	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	29-kDa	29-kda	JJ	JJ	_	12	amod	_	_
11	proteolysis-resisting	proteolysis-resisting	JJ	JJ	_	12	amod	_	_
12	fragment	fragment	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	whereas	whereas	IN	IN	_	17	mark	_	_
15	antiandrogen	antiandrogen	JJ	JJ	_	16	amod	_	_
16	binding	binding	NN	NN	_	17	nsubj	_	_
17	stabilised	stabilise	VBD	VBD	_	7	advcl	_	_
18	a	a	DT	DT	_	20	det	_	_
19	35-kDa	35-kda	JJ	JJ	_	20	amod	_	_
20	fragment	fragment	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	fragments	fragment	NNS	NNS	_	3	nsubj	_	_
3	contain	contain	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	entire	entire	JJ	JJ	_	8	amod	_	_
6	ligand	ligand	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	3	dobj	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	35-kDa	35-kda	JJ	JJ	_	13	amod	_	_
13	fragment	fragment	NN	NN	_	14	nsubj	_	_
14	extended	extend	VBD	VBD	_	3	conj	_	_
15	into	into	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	hinge	hinge	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	receptor	receptor	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	antiandrogens	antiandrogen	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	agonistic	agonistic	JJ	JJ	_	5	amod	_	_
5	properties	property	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	mutated	mutate	VBN	VBN	_	10	amod	_	_
9	androgen	androgen	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	LNCaP	lncap	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	variant	variant	NN	NN	_	10	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	;	;	:	:	_	3	punct	_	_
17	trypsin	trypsin	NN	NN	_	18	compound	_	_
18	digestion	digestion	NN	NN	_	24	nsubj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	antiandrogen-bound	antiandrogen-bound	JJ	JJ	_	22	amod	_	_
21	mutated	mutate	VBN	VBN	_	22	amod	_	_
22	receptor	receptor	NN	NN	_	18	nmod	_	_
23	also	also	RB	RB	_	24	advmod	_	_
24	resulted	result	VBD	VBD	_	3	parataxis	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	29-kDa	29-kda	JJ	JJ	_	28	amod	_	_
28	fragment	fragment	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	point	point	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	important	important	JJ	JJ	_	7	amod	_	_
7	difference	difference	NN	NN	_	3	nmod	_	_
8	between	between	IN	IN	_	9	case	_	_
9	antiandrogens	antiandrogen	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	antagonists	antagonist	NNS	NNS	_	9	conj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	other	other	JJ	JJ	_	16	amod	_	_
14	steroid	steroid	NN	NN	_	16	compound	_	_
15	hormone	hormone	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Antiandrogens	antiandrogen	NNS	NNS	_	2	nsubj	_	_
2	result	result	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	4	case	_	_
4	protection	protection	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	the	the	DT	DT	_	9	det	_	_
8	hinge	hinge	NN	NN	_	9	compound	_	_
9	region	region	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	C-terminus	c-terminus	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	androgen	androgen	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	18	compound	_	_
16	agonist	agonist	NN	NN	_	18	compound	_	_
17	proteolytic	proteolytic	JJ	JJ	_	18	amod	_	_
18	attack	attack	NN	NN	_	9	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	whereas	whereas	IN	IN	_	23	mark	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	studies	study	NNS	NNS	_	23	nsubj	_	_
23	showed	show	VBD	VBD	_	2	advcl	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	antiestrogens	antiestrogen	NNS	NNS	_	28	nsubj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	antiprogestagens	antiprogestagen	NNS	NNS	_	25	conj	_	_
28	expose	expose	VBP	VBP	_	23	ccomp	_	_
29	the	the	DT	DT	_	31	det	_	_
30	C-terminal	c-terminal	JJ	JJ	_	31	amod	_	_
31	end	end	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	ligand	ligand	NN	NN	_	36	compound	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	domain	domain	NN	NN	_	31	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	their	they	PRP$	PRP$	_	40	nmod:poss	_	_
39	respective	respective	JJ	JJ	_	40	amod	_	_
40	receptors	receptor	NNS	NNS	_	36	nmod	_	_
41	to	to	TO	TO	_	42	case	_	_
42	protease	protease	NN	NN	_	28	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Differences	difference	NNS	NNS	_	8	nsubj	_	_
2	in	in	IN	IN	_	3	case	_	_
3	conformation	conformation	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	hinge	hinge	NN	NN	_	7	compound	_	_
7	region	region	NN	NN	_	3	nmod	_	_
8	distinguish	distinguish	VBP	VBP	_	0	root	_	_
9	androgen-bound	androgen-bound	JJ	JJ	_	8	dobj	_	_
10	from	from	IN	IN	_	13	case	_	_
11	antiandrogen-bound	antiandrogen-bound	JJ	JJ	_	13	amod	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	complexes	complex	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	represents	represent	VBZ	VBZ	_	8	dep	_	_
17	an	a	DT	DT	_	19	det	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	feature	feature	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	antiandrogen	antiandrogen	JJ	JJ	_	22	amod	_	_
22	action	action	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	An	a	DT	DT	_	6	det	_	_
2	active	active	JJ	JJ	_	6	amod	_	_
3	v-abl	v-abl	JJ	JJ	_	6	amod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	7	nsubj	_	_
7	blocks	block	VBZ	VBZ	_	0	root	_	_
8	immunoglobulin	immunoglobulin	NN	NN	_	10	compound	_	_
9	light-chain	light-chain	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	rearrangement	rearrangement	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Lymphoid	lymphoid	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	10	nsubj	_	_
3	transformed	transform	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	8	case	_	_
5	Abelson	abelson	NN	NN	_	8	compound	_	_
6	murine	murine	NN	NN	_	8	compound	_	_
7	leukemia	leukemia	NN	NN	_	8	compound	_	_
8	virus	virus	NN	NN	_	3	nmod	_	_
9	have	have	VBP	VBP	_	10	aux	_	_
10	provided	provide	VBN	VBN	_	0	root	_	_
11	one	one	CD	CD	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	classic	classic	JJ	JJ	_	15	amod	_	_
15	models	model	NNS	NNS	_	11	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	study	study	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	early	early	JJ	JJ	_	21	amod	_	_
20	B-cell	b-cell	NN	NN	_	21	compound	_	_
21	development	development	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
24	rearrangement	rearrangement	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	10	punct	_	_

1	Most	most	JJS	JJS	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	rearranged	rearrange	VBN	VBN	_	0	root	_	_
7	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
8	heavy-chain	heavy-chain	JJ	JJ	_	9	amod	_	_
9	locus	locus	NN	NN	_	6	dobj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
13	light	light	JJ	JJ	_	15	amod	_	_
14	chain	chain	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	9	conj	_	_
16	,	,	,	,	_	6	punct	_	_
17	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	an	a	DT	DT	_	22	det	_	_
20	active	active	JJ	JJ	_	22	amod	_	_
21	v-abl	v-abl	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	23	nsubj	_	_
23	interferes	interfere	VBZ	VBZ	_	17	ccomp	_	_
24	with	with	IN	IN	_	27	case	_	_
25	this	this	DT	DT	_	27	det	_	_
26	differentiation	differentiation	NN	NN	_	27	compound	_	_
27	step	step	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	light-chain	light-chain	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	structure	structure	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	examined	examine	VBN	VBN	_	2	parataxis	_	_
11	in	in	IN	IN	_	13	case	_	_
12	pre-B	pre-b	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	transformed	transform	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	temperature-sensitive	temperature-sensitive	JJ	JJ	_	17	amod	_	_
17	mutants	mutant	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Abelson	abelson	NN	NN	_	21	compound	_	_
21	virus	virus	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	in	in	IN	IN	_	24	case	_	_
24	derivatives	derivative	NNS	NNS	_	13	conj	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	survive	survive	VBP	VBP	_	24	acl:relcl	_	_
27	at	at	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	nonpermissive	nonpermissive	JJ	JJ	_	30	amod	_	_
30	temperature	temperature	NN	NN	_	26	nmod	_	_
31	because	because	IN	IN	_	33	mark	_	_
32	they	they	PRP	PRP	_	33	nsubj	_	_
33	express	express	VBP	VBP	_	26	advcl	_	_
34	a	a	DT	DT	_	37	det	_	_
35	human	human	JJ	JJ	_	37	amod	_	_
36	BCL-2	bcl-2	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	inactivation	inactivation	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	v-abl	v-abl	JJ	JJ	_	11	amod	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	5	nmod	_	_
12	triggers	trigger	NNS	NNS	_	3	ccomp	_	_
13	high-frequency	high-frequency	VBP	VBP	_	14	dep	_	_
14	rearrangement	rearrangement	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	kappa	kappa	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	lambda	lambda	NN	NN	_	16	conj	_	_
19	light-chain	light-chain	JJ	JJ	_	20	amod	_	_
20	genes	gene	NNS	NNS	_	16	dep	_	_
21	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	events	event	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	marked	marked	JJ	JJ	_	7	amod	_	_
7	increases	increase	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	RAG-1	rag-1	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	RAG-2	rag-2	NN	NN	_	12	conj	_	_
15	RNAs	rna	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	increases	increase	NNS	NNS	_	3	nsubj	_	_
3	occur	occur	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	absence	absence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	6	nmod	_	_
10	but	but	CC	CC	_	3	cc	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	dependent	dependent	JJ	JJ	_	3	conj	_	_
13	on	on	IN	IN	_	14	case	_	_
14	inactivation	inactivation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	v-abl	v-abl	JJ	JJ	_	20	amod	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	tyrosine	tyrosine	NN	NN	_	20	compound	_	_
20	kinase	kinase	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	documented	document	VBN	VBN	_	21	dep	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	accompanying	accompany	VBG	VBG	_	6	amod	_	_
6	paper	paper	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Klug	klug	NN	NN	_	2	dep	_	_
9	et	et	FW	FW	_	8	compound	_	_
10	al.	al.	FW	FW	_	8	dep	_	_
11	,	,	,	,	_	8	punct	_	_
12	this	this	DT	DT	_	13	det	_	_
13	issue	issue	NN	NN	_	8	appos	_	_
14	)	)	-RRB-	-RRB-	_	8	punct	_	_
15	,	,	,	,	_	21	punct	_	_
16	an	a	DT	DT	_	19	det	_	_
17	active	active	JJ	JJ	_	19	amod	_	_
18	v-abl	v-abl	JJ	JJ	_	19	amod	_	_
19	protein	protein	NN	NN	_	21	nsubj	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B/rel	b/rel	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	expression	expression	NN	NN	_	23	conj	_	_
29	controlled	control	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	kappa	kappa	NN	NN	_	34	compound	_	_
33	intron	intron	NN	NN	_	34	compound	_	_
34	enhancer	enhancer	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	21	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	v-abl	v-abl	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	10	nsubj	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	interferes	interfere	VBZ	VBZ	_	4	ccomp	_	_
11	with	with	IN	IN	_	14	case	_	_
12	light-chain	light-chain	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	rearrangement	rearrangement	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	suppressing	suppress	VBG	VBG	_	10	advcl	_	_
17	at	at	IN	IN	_	18	case	_	_
18	least	least	JJS	JJS	_	19	nmod:npmod	_	_
19	two	two	CD	CD	_	20	nummod	_	_
20	pathways	pathway	NNS	NNS	_	16	dobj	_	_
21	essential	essential	JJ	JJ	_	20	amod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	stage	stage	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	B-cell	b-cell	NN	NN	_	27	compound	_	_
27	differentiation	differentiation	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	4	cc	_	_
29	suggest	suggest	VBP	VBP	_	4	conj	_	_
30	that	that	IN	IN	_	34	mark	_	_
31	tyrosine	tyrosine	NN	NN	_	32	compound	_	_
32	phosphorylation	phosphorylation	NN	NN	_	34	nsubj	_	_
33	is	be	VBZ	VBZ	_	34	cop	_	_
34	important	important	JJ	JJ	_	29	ccomp	_	_
35	in	in	IN	IN	_	36	mark	_	_
36	regulating	regulate	VBG	VBG	_	34	advcl	_	_
37	RAG	rag	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	36	dobj	_	_
40	.	.	.	.	_	4	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	9	punct	_	_
2	An	a	DT	DT	_	3	det	_	_
3	overexpression	overexpression	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
6	acid	acid	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	3	nmod	_	_
9	blocks	block	VBZ	VBZ	_	0	root	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	differentiation	differentiation	NN	NN	_	9	dobj	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	promyelocyte	promyelocyte	JJ	JJ	_	16	amod	_	_
16	stage	stage	NN	NN	_	9	nmod	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	9	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	a	a	DT	DT	_	9	det	_	_
8	vitamin	vitamin	NN	NN	_	9	compound	_	_
9	A	a	NN	NN	_	2	appos	_	_
10	derivative	derivative	JJ	JJ	_	9	amod	_	_
11	,	,	,	,	_	2	punct	_	_
12	exerts	exert	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	wide	wide	JJ	JJ	_	15	amod	_	_
15	range	range	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	biological	biological	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	15	nmod	_	_
19	related	related	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	cell	cell	NN	NN	_	19	nmod	_	_
22	proliferation	proliferation	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	differentiation	differentiation	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	pleiotropic	pleiotropic	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	RA	ra	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	thought	think	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	7	xcomp	_	_
11	through	through	IN	IN	_	15	case	_	_
12	specific	specific	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	12	dep	_	_
14	RA	ra	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	RARs	rar	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	7	punct	_	_

1	RARs	rar	NNS	NNS	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	members	member	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	steroid/thyroid	steroid/thyroid	NN	NN	_	9	compound	_	_
7	hormone	hormone	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	superfamily	superfamily	NN	NN	_	3	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	exhibit	exhibit	VBP	VBP	_	3	conj	_	_
12	a	a	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	structure	structure	NN	NN	_	11	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	possess	possess	VBP	VBP	_	14	acl:relcl	_	_
17	discrete	discrete	JJ	JJ	_	18	amod	_	_
18	DNA-binding	dna-binding	JJ	JJ	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	RA	ra	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	ligand	ligand	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	-binding	-binding	JJ	JJ	_	25	amod	_	_
25	domains	domain	NNS	NNS	_	18	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	hematopoietic	hematopoietic	JJ	JJ	_	3	amod	_	_
3	system	system	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	RA	ra	NN	NN	_	13	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	RARs	rar	NNS	NNS	_	5	conj	_	_
8	,	,	,	,	_	7	punct	_	_
9	predominantly	predominantly	RB	RB	_	11	advmod	_	_
10	RAR	rar	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	7	appos	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	play	play	VB	VB	_	0	root	_	_
14	key	key	JJ	JJ	_	15	amod	_	_
15	roles	role	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	dep	_	_
18	proliferation	proliferation	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	differentiation	differentiation	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	23	amod	_	_
23	progenitors	progenitor	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	currently	currently	RB	RB	_	6	advmod	_	_
6	unknown	unknown	JJ	JJ	_	0	root	_	_
7	how	how	WRB	WRB	_	12	advmod	_	_
8	RA	ra	NN	NN	_	12	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	RARs	rar	NNS	NNS	_	8	conj	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	6	ccomp	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	regulating	regulate	VBG	VBG	_	12	advcl	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	hematopoietic	hematopoietic	JJ	JJ	_	15	dep	_	_
17	differentiation	differentiation	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	make	make	VB	VB	_	0	root	_	_
3	clear	clear	JJ	JJ	_	2	xcomp	_	_
4	the	the	DT	DT	_	5	det	_	_
5	roles	role	NNS	NNS	_	3	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	RA	ra	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	RAR	rar	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	normal	normal	JJ	JJ	_	14	amod	_	_
14	hematopoiesis	hematopoiesis	NN	NN	_	5	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	I	I	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	introduced	introduce	VBN	VBN	_	2	parataxis	_	_
19	the	the	DT	DT	_	20	det	_	_
20	construct	construct	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	RAR	rar	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	hRAR	hrar	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	into	into	IN	IN	_	33	case	_	_
30	murine	murine	NN	NN	_	33	compound	_	_
31	bone	bone	NN	NN	_	33	compound	_	_
32	marrow	marrow	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	18	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	retroviral	retroviral	JJ	JJ	_	36	amod	_	_
36	vector	vector	NN	NN	_	18	nmod	_	_
37	,	,	,	,	_	18	punct	_	_
38	and	and	CC	CC	_	18	cc	_	_
39	selected	select	VBN	VBN	_	18	conj	_	_
40	infected	infected	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	39	dobj	_	_
42	with	with	IN	IN	_	45	case	_	_
43	drug	drug	NN	NN	_	45	compound	_	_
44	resistant	resistant	JJ	JJ	_	45	amod	_	_
45	marker	marker	NN	NN	_	41	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	Neo(r)	neo(r)	NN	NN	_	45	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	cultured	culture	VBN	VBN	_	45	acl	_	_
50	on	on	IN	IN	_	54	case	_	_
51	the	the	DT	DT	_	54	det	_	_
52	stroma	stroma	NN	NN	_	54	compound	_	_
53	cell	cell	NN	NN	_	54	compound	_	_
54	line	line	NN	NN	_	49	nmod	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	PA6-neo	pa6-neo	JJ	JJ	_	54	dep	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	,	,	,	,	_	18	punct	_	_
59	and	and	CC	CC	_	18	cc	_	_
60	analyzed	analyze	VBN	VBN	_	18	conj	_	_
61	the	the	DT	DT	_	62	det	_	_
62	behavior	behavior	NN	NN	_	60	dobj	_	_
63	of	of	IN	IN	_	65	case	_	_
64	infected	infected	JJ	JJ	_	65	amod	_	_
65	cells	cell	NNS	NNS	_	62	nmod	_	_
66	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	procedure	procedure	NN	NN	_	1	nmod	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	done	do	VBN	VBN	_	0	root	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	5	advmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	7	nsubj	_	_
3	infected	infect	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	6	case	_	_
5	hRAR	hrar	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	3	nmod	_	_
7	exhibited	exhibit	VBD	VBD	_	0	root	_	_
8	promyelocytic	promyelocytic	JJ	JJ	_	9	amod	_	_
9	morphology	morphology	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	thought	think	VBN	VBN	_	7	conj	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	blocked	block	VBN	VBN	_	12	xcomp	_	_
16	at	at	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	promyelocytic	promyelocytic	JJ	JJ	_	19	amod	_	_
19	stage	stage	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
22	myeloid	myeloid	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	5	det	_	_
4	immature	immature	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	differentiated	differentiate	VBD	VBD	_	0	root	_	_
7	terminally	terminally	RB	RB	_	6	advmod	_	_
8	into	into	IN	IN	_	10	case	_	_
9	mature	mature	JJ	JJ	_	10	amod	_	_
10	granulocytes	granulocyte	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	adding	add	VBG	VBG	_	6	advcl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	RA	ra	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	10(-6)	10(-6)	CD	CD	_	17	nummod	_	_
17	M	m	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	6	punct	_	_

1	RAR	rar	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	7	nsubj	_	_
3	infected	infected	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	2	dep	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	differentiate	differentiate	VB	VB	_	7	xcomp	_	_
10	into	into	IN	IN	_	12	case	_	_
11	mature	mature	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	the	the	DT	DT	_	9	nmod	_	_
15	both	both	CC	CC	_	14	dep	_	_
16	of	of	IN	IN	_	19	case	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	term	term	NN	NN	_	19	compound	_	_
19	culture	culture	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL3	il3	NN	NN	_	22	compound	_	_
22	colony	colony	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	an	a	DT	DT	_	6	det	_	_
6	overexpression	overexpression	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	RAR	rar	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	6	nmod	_	_
10	alone	alone	RB	RB	_	9	advmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	effective	effective	JJ	JJ	_	3	dep	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	suppress	suppress	VB	VB	_	12	xcomp	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	14	dobj	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	RAR	rar	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	21	nsubj	_	_
21	plays	play	VBZ	VBZ	_	12	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	crucial	crucial	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	terminal	terminal	JJ	JJ	_	28	amod	_	_
28	differentiation	differentiation	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	myeloid	myeloid	JJ	JJ	_	31	amod	_	_
31	precursors	precursor	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	system	system	NN	NN	_	6	nsubj	_	_
3	described	describe	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	serve	serve	VB	VB	_	0	root	_	_
7	as	as	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	model	model	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	studying	study	VBG	VBG	_	9	acl	_	_
12	the	the	DT	DT	_	15	dep	_	_
13	the	the	DT	DT	_	15	det	_	_
14	essential	essential	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	11	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	differentiation	differentiation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	normal	normal	JJ	JJ	_	22	amod	_	_
20	bone	bone	NN	NN	_	22	compound	_	_
21	marrow	marrow	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	chain	chain	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	factor.kappa	factor.kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	1	conj	_	_
13	by	by	IN	IN	_	16	case	_	_
14	protein	protein	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	C	c	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Autocrine	autocrine	NN	NN	_	2	compound	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	tumor	tumor	NN	NN	_	7	compound	_	_
5	necrosis	necrosis	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	34	nsubjpass	_	_
3	of	of	IN	IN	_	12	case	_	_
4	interleukin-2	interleukin-2	NN	NN	_	7	compound	_	_
5	receptor	receptor	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	chain	chain	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	IL-2R	il-2r	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	expression	expression	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	NF	nf	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	activation	activation	NN	NN	_	2	conj	_	_
20	by	by	IN	IN	_	23	case	_	_
21	protein	protein	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	C	c	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PKC	pkc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	30	case	_	_
28	resting	rest	VBG	VBG	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	23	nmod	_	_
31	,	,	,	,	_	2	punct	_	_
32	has	have	VBZ	VBZ	_	34	aux	_	_
33	been	be	VBN	VBN	_	34	auxpass	_	_
34	studied	study	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	resting	rest	VBG	VBG	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	phorbol	phorbol	NN	NN	_	9	compound	_	_
9	esters	ester	NNS	NNS	_	1	nmod	_	_
10	strongly	strongly	RB	RB	_	11	advmod	_	_
11	induced	induce	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	IL-2R	il-2r	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	13	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF.kappa	nf.kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	due	due	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	translocation	translocation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	p65	p65	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	c-Rel	c-rel	NN	NN	_	14	compound	_	_
12	NF.kappa	nf.kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	9	conj	_	_
15	from	from	IN	IN	_	17	case	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
17	stores	store	NNS	NNS	_	7	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nucleus	nucleus	NN	NN	_	7	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	where	where	WRB	WRB	_	24	advmod	_	_
23	they	they	PRP	PRP	_	24	nsubj	_	_
24	bound	bind	VBD	VBD	_	20	acl:relcl	_	_
25	the	the	DT	DT	_	28	det	_	_
26	kappa	kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	24	dobj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	IL-2R	il-2r	NN	NN	_	33	compound	_	_
32	alpha	alpha	NN	NN	_	33	compound	_	_
33	promoter	promoter	NN	NN	_	28	nmod	_	_
34	either	either	CC	CC	_	36	cc:preconj	_	_
35	as	as	IN	IN	_	36	case	_	_
36	p50.p65	p50.p65	NN	NN	_	24	nmod	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	as	as	IN	IN	_	40	case	_	_
39	p50.c-Rel	p50.c-rel	NN	NN	_	40	compound	_	_
40	heterodimers	heterodimer	NNS	NNS	_	36	conj	_	_
41	.	.	.	.	_	4	punct	_	_

1	Interestingly	interestingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	all	all	DT	DT	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	those	those	DT	DT	_	6	det	_	_
6	events	event	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	largely	largely	RB	RB	_	9	advmod	_	_
9	indirect	indirect	JJ	JJ	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	mediated	mediate	VBN	VBN	_	9	conj	_	_
12	by	by	IN	IN	_	18	case	_	_
13	endogenously	endogenously	RB	RB	_	14	advmod	_	_
14	secreted	secrete	VBN	VBN	_	18	amod	_	_
15	tumor	tumor	NN	NN	_	18	compound	_	_
16	necrosis	necrosis	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	11	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	TNF	tnf	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	9	punct	_	_
24	as	as	IN	IN	_	28	mark	_	_
25	they	they	PRP	PRP	_	28	nsubjpass	_	_
26	were	be	VBD	VBD	_	28	auxpass	_	_
27	strongly	strongly	RB	RB	_	28	advmod	_	_
28	inhibited	inhibit	VBN	VBN	_	9	advcl	_	_
29	by	by	IN	IN	_	35	case	_	_
30	a	a	DT	DT	_	35	det	_	_
31	neutralizing	neutralize	VBG	VBG	_	35	amod	_	_
32	anti-TNF	anti-tnf	JJ	JJ	_	35	amod	_	_
33	alpha	alpha	NN	NN	_	35	compound	_	_
34	monoclonal	monoclonal	JJ	JJ	_	35	amod	_	_
35	antibody	antibody	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	cyclosporin	cyclosporin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	16	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	blocked	block	VBD	VBD	_	4	acl:relcl	_	_
8	TNF	tnf	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	production	production	NN	NN	_	7	dobj	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	PKC	pkc	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	strongly	strongly	RB	RB	_	16	advmod	_	_
16	inhibited	inhibit	VBD	VBD	_	0	root	_	_
17	IL-2R	il-2r	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NF.kappa	nf.kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	either	either	CC	CC	_	6	cc:preconj	_	_
5	TNF	tnf	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	2	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	IL-2	il-2	NN	NN	_	6	conj	_	_
9	partially	partially	RB	RB	_	10	advmod	_	_
10	recovered	recover	VBD	VBD	_	0	root	_	_
11	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
12	A-induced	a-induced	JJ	JJ	_	15	amod	_	_
13	IL-2R	il-2r	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	inhibition	inhibition	NN	NN	_	10	dobj	_	_
16	,	,	,	,	_	10	punct	_	_
17	but	but	CC	CC	_	10	cc	_	_
18	only	only	RB	RB	_	20	advmod	_	_
19	TNF	tnf	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	22	nsubj	_	_
21	completely	completely	RB	RB	_	22	advmod	_	_
22	recovered	recover	VBD	VBD	_	10	conj	_	_
23	NF.kappa	nf.kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	10	punct	_	_

1	Those	those	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	,	,	,	,	_	13	punct	_	_
6	in	in	IN	IN	_	9	case	_	_
7	resting	rest	VBG	VBG	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	13	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	PKC	pkc	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	13	nsubj	_	_
13	has	have	VBZ	VBZ	_	3	ccomp	_	_
14	only	only	RB	RB	_	17	advmod	_	_
15	a	a	DT	DT	_	17	det	_	_
16	triggering	trigger	VBG	VBG	_	17	amod	_	_
17	role	role	NN	NN	_	13	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	whereas	whereas	IN	IN	_	25	mark	_	_
20	the	the	DT	DT	_	24	det	_	_
21	endogenously	endogenously	RB	RB	_	22	advmod	_	_
22	secreted	secrete	VBN	VBN	_	24	amod	_	_
23	TNF	tnf	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	25	nsubj	_	_
25	plays	play	VBZ	VBZ	_	13	advcl	_	_
26	an	a	DT	DT	_	28	det	_	_
27	essential	essential	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	quantitative	quantitative	JJ	JJ	_	32	amod	_	_
32	control	control	NN	NN	_	25	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	expression	expression	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	IL-2R	il-2r	NN	NN	_	38	compound	_	_
38	alpha	alpha	NN	NN	_	39	compound	_	_
39	chain	chain	NN	NN	_	35	nmod	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	NF.kappa	nf.kappa	NN	NN	_	42	compound	_	_
42	B	b	NN	NN	_	43	compound	_	_
43	activation	activation	NN	NN	_	39	conj	_	_
44	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	cellular	cellular	JJ	JJ	_	7	amod	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	E2F	e2f	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	cdc2	cdc2	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	cycle	cycle	NN	NN	_	18	compound	_	_
18	control	control	NN	NN	_	10	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	cdc2	cdc2	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	transcripts	transcript	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	immature	immature	JJ	JJ	_	10	amod	_	_
8	bone	bone	NN	NN	_	10	compound	_	_
9	marrow	marrow	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	became	become	VBD	VBD	_	5	conj	_	_
13	undetectable	undetectable	JJ	JJ	_	12	xcomp	_	_
14	along	along	IN	IN	_	16	case	_	_
15	with	with	IN	IN	_	16	case	_	_
16	differentiation	differentiation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	resting	resting	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	express	express	VB	VB	_	0	root	_	_
8	cdc2	cdc2	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	it	it	PRP	PRP	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	7	conj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	T-lymphocytes	t-lymphocyte	NNS	NNS	_	14	nmod	_	_
17	when	when	WRB	WRB	_	20	advmod	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	20	nsubj	_	_
20	reentered	reenter	VBD	VBD	_	14	advcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	cycle	cycle	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	response	response	NN	NN	_	20	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	specific	specific	JJ	JJ	_	28	amod	_	_
28	mitogens	mitogen	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	cdc2	cdc2	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	9	nsubjpass	_	_
6	could	could	MD	MD	_	9	aux	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	granulocytes	granulocyte	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	monocytes	monocyte	NNS	NNS	_	11	conj	_	_
14	even	even	RB	RB	_	9	advmod	_	_
15	after	after	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	culture	culture	NN	NN	_	9	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	appropriate	appropriate	JJ	JJ	_	21	amod	_	_
21	stimulants	stimulant	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	19	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	cdc2	cdc2	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	hematopoietic	hematopoietic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	isolated	isolate	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	22	det	_	_
21	5'-flanking	5'-flanking	JJ	JJ	_	22	amod	_	_
22	sequence	sequence	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cdc2	cdc2	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	found	find	VBD	VBD	_	19	conj	_	_
29	the	the	DT	DT	_	31	det	_	_
30	putative	putative	JJ	JJ	_	31	amod	_	_
31	E2F	e2f	NN	NN	_	28	dobj	_	_
32	binding	binding	NN	NN	_	33	compound	_	_
33	site	site	NN	NN	_	31	dep	_	_
34	at	at	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	position	position	NN	NN	_	28	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	nucleotides	nucleotide	NNS	NNS	_	36	nmod	_	_
39	-124	-124	CD	CD	_	38	nummod	_	_
40	to	to	TO	TO	_	38	dep	_	_
41	-117	-117	CD	CD	_	38	nummod	_	_
42	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E2F	e2f	NN	NN	_	2	nmod	_	_
5	at	at	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	region	region	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	gel-retardation	gel-retardation	NN	NN	_	13	compound	_	_
13	assay	assay	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	DNaseI	dnasei	NN	NN	_	16	compound	_	_
16	footprinting	footprinting	NN	NN	_	13	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	phytohemagglutinin-stimulated	phytohemagglutinin-stimulated	JJ	JJ	_	19	amod	_	_
19	T-lymphocytes	t-lymphocyte	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	which	which	WDT	WDT	_	23	nsubj	_	_
22	was	be	VBD	VBD	_	23	cop	_	_
23	coincident	coincident	JJ	JJ	_	9	ccomp	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	cdc2	cdc2	NN	NN	_	29	compound	_	_
29	mRNA	mrna	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	E2F	e2f	NN	NN	_	2	compound	_	_
2	binding	binding	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	granulocytes	granulocyte	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	monocytes	monocyte	NNS	NNS	_	8	conj	_	_
11	.	.	.	.	_	5	punct	_	_

1	Transient	transient	JJ	JJ	_	4	amod	_	_
2	chloramphenicol	chloramphenicol	NN	NN	_	3	compound	_	_
3	acetyltransferase	acetyltransferase	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	region	region	NN	NN	_	13	nsubj	_	_
9	containing	contain	VBG	VBG	_	8	acl	_	_
10	E2F	e2f	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	9	dobj	_	_
13	had	have	VBD	VBD	_	5	dep	_	_
14	a	a	DT	DT	_	17	det	_	_
15	strong	strong	JJ	JJ	_	17	amod	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	introduction	introduction	NN	NN	_	29	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	mutation	mutation	NN	NN	_	20	nmod	_	_
24	at	at	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	E2F	e2f	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	20	nmod	_	_
29	resulted	result	VBD	VBD	_	13	conj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	significant	significant	JJ	JJ	_	33	amod	_	_
33	loss	loss	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	activity	activity	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	E2F-1	e2f-1	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	DP-1	dp-1	NN	NN	_	1	conj	_	_
4	mRNAs	mrna	NNS	NNS	_	1	dep	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	detectable	detectable	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	granulocytes	granulocyte	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	monocytes	monocyte	NNS	NNS	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	resting	rest	VBG	VBG	_	14	amod	_	_
14	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	conj	_	_
15	but	but	CC	CC	_	7	cc	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	7	conj	_	_
18	after	after	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	mitogenic	mitogenic	JJ	JJ	_	21	amod	_	_
21	stimulation	stimulation	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	T-lymphocytes	t-lymphocyte	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	E2F	e2f	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	preceded	precede	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	appearance	appearance	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	cdc2	cdc2	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	consistent	consistent	JJ	JJ	_	6	dep	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	E2F	e2f	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	cdc2	cdc2	NN	NN	_	27	compound	_	_
26	mRNA	mrna	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	cdc2	cdc2	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	related	related	JJ	JJ	_	3	ccomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	cycling	cycling	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	normal	normal	JJ	JJ	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	that	that	IN	IN	_	22	mark	_	_
21	E2F	e2f	NN	NN	_	22	nsubj	_	_
22	plays	play	VBZ	VBZ	_	9	conj	_	_
23	some	some	DT	DT	_	24	det	_	_
24	roles	role	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	regulation	regulation	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
30	expression	expression	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Protease	protease	NN	NN	_	2	compound	_	_
2	inhibitors	inhibitor	NNS	NNS	_	3	nsubj	_	_
3	block	block	VBP	VBP	_	0	root	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	tissue	tissue	NN	NN	_	10	compound	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	5	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	preventing	prevent	VBG	VBG	_	3	advcl	_	_
17	activation	activation	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	c-Rel/p65	c-rel/p65	NN	NN	_	20	compound	_	_
20	heterodimers	heterodimer	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Tissue	tissue	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	TF	tf	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	rapidly	rapidly	RB	RB	_	7	advmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
12	exposed	expose	VBN	VBN	_	11	acl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	bacterial	bacterial	JJ	JJ	_	15	amod	_	_
15	endotoxin	endotoxin	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	lipopolysaccharide	lipopolysaccharide	NN	NN	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	or	or	CC	CC	_	17	cc	_	_
20	LPS	lps	NN	NN	_	17	conj	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	binding	binding	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	c-Rel/p65	c-rel/p65	NN	NN	_	9	compound	_	_
9	heterodimers	heterodimer	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B-like	b-like	JJ	JJ	_	14	amod	_	_
14	site	site	NN	NN	_	6	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	TF	tf	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cytosolic	cytosolic	JJ	JJ	_	6	amod	_	_
5	c-Rel/p65	c-rel/p65	NN	NN	_	6	compound	_	_
6	heterodimers	heterodimer	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	members	member	NNS	NNS	_	6	conj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
13	B/Rel	b/rel	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	9	nmod	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	dissociation	dissociation	NN	NN	_	15	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	proteolytic	proteolytic	JJ	JJ	_	19	amod	_	_
19	degradation	degradation	NN	NN	_	16	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	inhibitor	inhibitor	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	16	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	I	i	NN	NN	_	28	compound	_	_
26	kappa	kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	23	appos	_	_
29	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protease	protease	NN	NN	_	3	compound	_	_
3	inhibitors	inhibitor	NNS	NNS	_	19	nsubj	_	_
4	N	n	NN	NN	_	7	compound	_	_
5	alpha-tosylphenylalanyl	alpha-tosylphenylalanyl	JJ	JJ	_	7	amod	_	_
6	chloromethyl	chloromethyl	NN	NN	_	7	compound	_	_
7	ketone	ketone	NN	NN	_	3	dep	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	TPCK	tpck	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	N	n	NN	NN	_	15	compound	_	_
13	alpha-tosyl-L-lysine	alpha-tosyl-l-lysine	NN	NN	_	15	compound	_	_
14	chloromethyl	chloromethyl	NN	NN	_	15	compound	_	_
15	ketone	ketone	NN	NN	_	7	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TLCK	tlck	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	block	block	VBP	VBP	_	0	root	_	_
20	activation	activation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B/Rel	b/rel	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	20	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	preventing	prevent	VBG	VBG	_	19	advcl	_	_
27	degradation	degradation	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	I	i	NN	NN	_	32	compound	_	_
30	kappa	kappa	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	if	if	IN	IN	_	7	mark	_	_
4	TPCK	tpck	NN	NN	_	7	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TLCK	tlck	NN	NN	_	4	conj	_	_
7	inhibited	inhibit	VBD	VBD	_	2	advcl	_	_
8	LPS	lps	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	TF	tf	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	freshly	freshly	RB	RB	_	15	advmod	_	_
15	isolated	isolate	VBN	VBN	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	23	nsubjpass	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
20	THP-1	thp-1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	conj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	pretreated	pretreat	VBN	VBN	_	2	parataxis	_	_
24	with	with	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	inhibitors	inhibitor	NNS	NNS	_	23	nmod	_	_
27	for	for	IN	IN	_	29	case	_	_
28	30	30	CD	CD	_	29	nummod	_	_
29	min	min	NN	NN	_	23	nmod	_	_
30	before	before	IN	IN	_	32	case	_	_
31	LPS	lps	NN	NN	_	32	compound	_	_
32	stimulation	stimulation	NN	NN	_	23	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	TPCK	tpck	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	TLCK	tlck	NN	NN	_	2	conj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	LPS	lps	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	TF	tf	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	TF	tf	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	7	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	TF	tf	NN	NN	_	13	conj	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	dep	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	dose-dependent	dose-dependent	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	5	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	inhibitors	inhibitor	NNS	NNS	_	4	nsubj	_	_
3	specifically	specifically	RB	RB	_	4	advmod	_	_
4	prevented	prevent	VBD	VBD	_	0	root	_	_
5	degradation	degradation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	translocation	translocation	NN	NN	_	5	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	c-Rel/p65	c-rel/p65	NN	NN	_	16	compound	_	_
16	heterodimers	heterodimer	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	TPCK	tpck	NN	NN	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TLCK	tlck	NN	NN	_	4	conj	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	block	block	VB	VB	_	0	root	_	_
10	induction	induction	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	immediate-early	immediate-early	JJ	JJ	_	14	amod	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	encoding	encode	VBG	VBG	_	14	acl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	15	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	Egr-1	egr-1	NN	NN	_	18	appos	_	_
21	.	.	.	.	_	9	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	indicated	indicate	VBD	VBD	_	1	parataxis	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	inhibiting	inhibit	VBG	VBG	_	10	amod	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	c-Rel/p65	c-rel/p65	NN	NN	_	13	compound	_	_
13	heterodimers	heterodimer	NNS	NNS	_	10	nmod	_	_
14	prevented	prevent	VBD	VBD	_	6	ccomp	_	_
15	LPS	lps	NN	NN	_	16	compound	_	_
16	induction	induction	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	TF	tf	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	3	compound	_	_
3	regulation	regulation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	tumor	tumor	NN	NN	_	10	compound	_	_
7	necrosis	necrosis	NN	NN	_	10	compound	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	3	nsubj	_	_
3	contribute	contribute	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	chronic	chronic	JJ	JJ	_	6	amod	_	_
6	inflammation	inflammation	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	secretion	secretion	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	proteinases	proteinase	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Tumor	tumor	NN	NN	_	4	compound	_	_
2	necrosis	necrosis	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	TNF	tnf	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	particularly	particularly	RB	RB	_	11	advmod	_	_
11	important	important	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	process	process	NN	NN	_	11	nmod	_	_
15	because	because	IN	IN	_	18	case	_	_
16	of	of	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	ability	ability	NN	NN	_	11	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	regulate	regulate	VB	VB	_	18	acl	_	_
21	other	other	JJ	JJ	_	23	amod	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	mediators	mediator	NNS	NNS	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	an	a	DT	DT	_	26	dep	_	_
26	autocrine	autocrine	JJ	JJ	_	20	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	paracrine	paracrine	JJ	JJ	_	26	conj	_	_
29	fashion	fashion	NN	NN	_	26	dep	_	_
30	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	mechanism	mechanism	NN	NN	_	4	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	s	s	NNS	NNS	_	17	nsubjpass	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	responsible	responsible	JJ	JJ	_	4	amod	_	_
7	for	for	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	type-specific	type-specific	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	known	know	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	data	datum	NNS	NNS	_	2	dobj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	show	show	VB	VB	_	3	acl	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	13	nsubjpass	_	_
9	of	of	IN	IN	_	11	case	_	_
10	TNF	tnf	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	5	ccomp	_	_
14	by	by	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	C/EBP	c/ebp	NN	NN	_	19	compound	_	_
19	beta	beta	NN	NN	_	17	dep	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	NF-IL6	nf-il6	NN	NN	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	2	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	3	nsubj	_	_
3	activated	activate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	TNF	tnf	NN	NN	_	8	compound	_	_
6	alpha	alpha	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cotransfection	cotransfection	NN	NN	_	11	compound	_	_
11	assays	assay	NNS	NNS	_	3	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	bound	bind	VBD	VBD	_	3	conj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	it	it	PRP	PRP	_	13	nmod	_	_
16	at	at	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	site	site	NN	NN	_	13	nmod	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	failed	fail	VBD	VBD	_	18	acl:relcl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	bind	bind	VB	VB	_	20	xcomp	_	_
23	the	the	DT	DT	_	26	det	_	_
24	closely	closely	RB	RB	_	25	advmod	_	_
25	related	related	JJ	JJ	_	26	amod	_	_
26	protein	protein	NN	NN	_	22	dobj	_	_
27	C/EBP	c/ebp	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	26	dep	_	_
29	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	dominant-negative	dominant-negative	JJ	JJ	_	5	amod	_	_
5	version	version	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	C/EBP	c/ebp	NN	NN	_	8	compound	_	_
8	beta	beta	NN	NN	_	5	nmod	_	_
9	blocked	block	VBD	VBD	_	0	root	_	_
10	TNF	tnf	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	C/EBP	c/ebp	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	3	dobj	_	_
6	as	as	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	regulator	regulator	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	TNF	tnf	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	myelomonocytic	myelomonocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Simultaneous	simultaneous	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	Ig	ig	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Oct-2	oct-2	NN	NN	_	4	conj	_	_
7	synthesis	synthesis	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	reduction	reduction	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	surface	surface	NN	NN	_	15	compound	_	_
12	MHC	mhc	NN	NN	_	13	compound	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	13	nummod	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IL-6	il-6	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Terminal	terminal	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	plasma	plasma	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vivo	vivo	FW	FW	_	2	advmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	characterized	characterize	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	secretion	secretion	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Ig	ig	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	extinction	extinction	NN	NN	_	14	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	MHC	mhc	NN	NN	_	21	compound	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	21	nummod	_	_
23	expression	expression	NN	NN	_	18	nmod	_	_
24	on	on	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	surface	surface	NN	NN	_	18	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	IL-6	il-6	NN	NN	_	5	compound	_	_
5	signaling	signaling	NN	NN	_	6	nsubj	_	_
6	leads	lead	VBZ	VBZ	_	2	ccomp	_	_
7	to	to	TO	TO	_	9	case	_	_
8	marked	marked	JJ	JJ	_	9	amod	_	_
9	increases	increase	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	dep	_	_
12	synthesis	synthesis	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	secretion	secretion	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Ig	ig	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	clonal	clonal	JJ	JJ	_	22	amod	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	12	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	newly	newly	RB	RB	_	28	advmod	_	_
25	isolated	isolate	VBN	VBN	_	28	amod	_	_
26	polyclonal	polyclonal	JJ	JJ	_	28	amod	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	22	conj	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vitro	vitro	FW	FW	_	9	advmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-6-induced	il-6-induced	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	resemble	resemble	VBP	VBP	_	0	root	_	_
5	plasma	plasma	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	4	xcomp	_	_
7	in	in	IN	IN	_	8	case	_	_
8	ultrastructure	ultrastructure	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	12	case	_	_
11	reduced	reduce	VBN	VBN	_	12	amod	_	_
12	expression	expression	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	surface	surface	NN	NN	_	16	compound	_	_
15	MHC	mhc	NN	NN	_	16	compound	_	_
16	class	class	NN	NN	_	12	nmod	_	_
17	II	ii	CD	CD	_	16	nummod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	3	amod	_	_
2	Ig	ig	NN	NN	_	3	compound	_	_
3	synthesis	synthesis	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	result	result	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	coordinated	coordinate	VBN	VBN	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Ig	ig	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	without	without	IN	IN	_	15	case	_	_
15	promoter	promoter	NN	NN	_	10	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	isotype	isotype	NN	NN	_	18	compound	_	_
18	specificity	specificity	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	differential	differential	JJ	JJ	_	22	amod	_	_
22	accumulation	accumulation	NN	NN	_	10	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	mRNA	mrna	NN	NN	_	22	nmod	_	_
26	encoding	encode	VBG	VBG	_	25	acl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	secreted	secrete	VBN	VBN	_	29	amod	_	_
29	form	form	NN	NN	_	26	dobj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	Ig	ig	NN	NN	_	33	compound	_	_
32	heavy	heavy	JJ	JJ	_	33	amod	_	_
33	chain	chain	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	saturable	saturable	JJ	JJ	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	subject	subject	JJ	JJ	_	3	conj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	control	control	NN	NN	_	5	nmod	_	_
9	when	when	WRB	WRB	_	13	advmod	_	_
10	IL-6	il-6	NN	NN	_	11	compound	_	_
11	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	prolonged	prolonged	JJ	JJ	_	5	ccomp	_	_
14	.	.	.	.	_	3	punct	_	_

1	Coordinate	coordinate	JJ	JJ	_	23	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	temporal	temporal	JJ	JJ	_	4	amod	_	_
4	changes	change	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Ig	ig	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	23	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	23	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	synthesis	synthesis	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	B	b	NN	NN	_	20	compound	_	_
18	cell-enriched	cell-enriched	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	14	nmod	_	_
21	Oct-2	oct-2	NN	NN	_	20	dep	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	regulated	regulate	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	differentiation	differentiation	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	IL-6	il-6	NN	NN	_	3	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	3	advmod	_	_
11	recapitulates	recapitulate	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	hallmarks	hallmark	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	terminal	terminal	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	13	nmod	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vivo	vivo	FW	FW	_	17	advmod	_	_
20	;	;	:	:	_	11	punct	_	_
21	Oct-2	oct-2	NN	NN	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	have	have	VB	VB	_	11	parataxis	_	_
24	a	a	DT	DT	_	25	det	_	_
25	role	role	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	process	process	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	Inducible	inducible	JJ	JJ	_	2	amod	_	_
2	binding	binding	NN	NN	_	14	nsubjpass	_	_
3	to	to	TO	TO	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	c-fos	c-fos	NN	NN	_	8	compound	_	_
6	serum	serum	NN	NN	_	8	compound	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	2	nmod	_	_
9	during	during	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	2	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	regulated	regulate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	phosphotyrosine-containing	phosphotyrosine-containing	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proto-oncogene	proto-oncogene	NN	NN	_	3	compound	_	_
3	c-fos	c-fos	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	an	a	DT	DT	_	7	det	_	_
6	immediate-early	immediate-early	JJ	JJ	_	7	amod	_	_
7	gene	gene	NN	NN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	one	one	CD	CD	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	first	first	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	transcribed	transcribe	VBN	VBN	_	14	acl	_	_
16	after	after	IN	IN	_	17	case	_	_
17	stimulation	stimulation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	most	most	JJS	JJS	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	variety	variety	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	ligands	ligand	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Fos	fos	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	may	may	MD	MD	_	7	aux	_	_
4	be	be	VB	VB	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	pivotal	pivotal	JJ	JJ	_	7	amod	_	_
7	event	event	NN	NN	_	0	root	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	converting	convert	VBG	VBG	_	7	acl	_	_
10	ligand-receptor	ligand-receptor	JJ	JJ	_	11	amod	_	_
11	interactions	interaction	NNS	NNS	_	9	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	membrane	membrane	NN	NN	_	11	nmod	_	_
15	into	into	IN	IN	_	17	case	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	modulation	modulation	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	phenotype	phenotype	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	serum	serum	NN	NN	_	4	compound	_	_
3	response	response	NN	NN	_	4	compound	_	_
4	element	element	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SRE	sre	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	c-fos	c-fos	NN	NN	_	12	compound	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	4	nmod	_	_
13	participates	participate	VBZ	VBZ	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	induction	induction	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	transcription	transcription	NN	NN	_	15	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	various	various	JJ	JJ	_	21	amod	_	_
20	growth	growth	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	by	by	IN	IN	_	25	case	_	_
24	phorbol	phorbol	NN	NN	_	25	compound	_	_
25	esters	ester	NNS	NNS	_	21	conj	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	subsequent	subsequent	JJ	JJ	_	28	amod	_	_
28	squelching	squelching	NN	NN	_	15	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	transcription	transcription	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	an	a	DT	DT	_	7	det	_	_
5	inducible	inducible	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	Band	band	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
13	to	to	TO	TO	_	15	case	_	_
14	SRE	sre	NN	NN	_	15	compound	_	_
15	DNA	dna	NN	NN	_	12	nmod	_	_
16	within	within	IN	IN	_	18	case	_	_
17	10	10	CD	CD	_	18	nummod	_	_
18	min	min	NN	NN	_	12	nmod	_	_
19	after	after	IN	IN	_	21	case	_	_
20	mitogenic	mitogenic	JJ	JJ	_	21	amod	_	_
21	stimulation	stimulation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	PBL-T	pbl-t	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	and	and	CC	CC	_	12	cc	_	_
27	becomes	become	VBZ	VBZ	_	12	conj	_	_
28	nondetectable	nondetectable	JJ	JJ	_	27	xcomp	_	_
29	by	by	IN	IN	_	31	case	_	_
30	60	60	CD	CD	_	31	nummod	_	_
31	min	min	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Band	band	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	serum	serum	NN	NN	_	7	compound	_	_
6	response	response	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	plus	plus	CC	CC	_	7	cc	_	_
9	additional	additional	JJ	JJ	_	12	amod	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	s	s	NNS	NNS	_	7	conj	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	13	nsubj	_	_
3	that	that	WDT	WDT	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	phosphorylated	phosphorylate	VBN	VBN	_	2	acl:relcl	_	_
6	on	on	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	residue	residue	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	resting	rest	VBG	VBG	_	12	amod	_	_
12	PBL-T	pbl-t	NN	NN	_	9	nmod	_	_
13	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
14	binding	binding	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	component	component	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	Band	band	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	SRE	sre	NN	NN	_	24	compound	_	_
24	motif	motif	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	11	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	this	this	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	11	nsubj	_	_
9	no	no	RB	RB	_	10	neg	_	_
10	longer	longer	RBR	RBR	_	11	advmod	_	_
11	prevents	prevent	VBZ	VBZ	_	0	root	_	_
12	binding	binding	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	DNA	dna	NN	NN	_	12	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	Band	band	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	suppression	suppression	NN	NN	_	24	nsubjpass	_	_
21	of	of	IN	IN	_	22	case	_	_
22	binding	binding	NN	NN	_	20	nmod	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	restored	restore	VBN	VBN	_	11	conj	_	_
25	within	within	IN	IN	_	27	case	_	_
26	30	30	CD	CD	_	27	nummod	_	_
27	min	min	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	phosphorylated	phosphorylate	VBN	VBN	_	4	amod	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	residue	residue	NN	NN	_	7	nsubj	_	_
5	itself	itself	PRP	PRP	_	4	nmod:npmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	important	important	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	protein-protein	protein-protein	JJ	JJ	_	11	amod	_	_
11	interaction	interaction	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	rat	rat	NN	NN	_	4	compound	_	_
4	splenocyte	splenocyte	NN	NN	_	5	compound	_	_
5	proliferation	proliferation	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	methylprednisolone	methylprednisolone	NN	NN	_	1	nmod	_	_
8	:	:	:	:	_	1	punct	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vivo	vivo	FW	FW	_	9	dep	_	_
11	effect	effect	NN	NN	_	1	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	liposomal	liposomal	JJ	JJ	_	14	amod	_	_
14	formulation	formulation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	22	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	liposomal	liposomal	JJ	JJ	_	6	amod	_	_
6	formulation	formulation	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	methylprednisolone	methylprednisolone	NN	NN	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MPL	mpl	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	on	on	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	inhibition	inhibition	NN	NN	_	2	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	proliferation	proliferation	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	spleen	spleen	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	investigated	investigate	VBN	VBN	_	0	root	_	_
23	following	follow	VBG	VBG	_	25	case	_	_
24	IV	iv	CD	CD	_	25	nummod	_	_
25	dosing	dosing	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	rats	rat	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	22	punct	_	_

1	Liposomes	liposome	NNS	NNS	_	4	nsubj	_	_
2	do	do	VBP	VBP	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	alter	alter	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	suppressive	suppressive	JJ	JJ	_	7	amod	_	_
7	action	action	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	MPL	mpl	NN	NN	_	7	nmod	_	_
10	when	when	WRB	WRB	_	11	advmod	_	_
11	placed	place	VBN	VBN	_	4	advcl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	culture	culture	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Rat	rat	NN	NN	_	2	compound	_	_
2	splenocytes	splenocyte	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	have	have	VB	VB	_	4	xcomp	_	_
7	greater	greater	JJR	JJR	_	8	amod	_	_
8	sensitivity	sensitivity	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	MPL	mpl	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	EC50	ec50	NN	NN	_	8	dep	_	_
13	=	=	JJ	JJ	_	12	amod	_	_
14	7.9	7.9	CD	CD	_	15	nummod	_	_
15	nM	nm	NN	NN	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	than	than	IN	IN	_	18	dep	_	_
18	do	do	VBP	VBP	_	6	advcl	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	18	nsubj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	EC50	ec50	NN	NN	_	22	dep	_	_
25	=	=	JJ	JJ	_	24	amod	_	_
26	28	28	CD	CD	_	27	nummod	_	_
27	nM	nm	NN	NN	_	25	dep	_	_
28	)	)	-RRB-	-RRB-	_	24	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	6	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	rats	rat	NNS	NNS	_	3	nmod	_	_
6	utilized	utilize	VBD	VBD	_	0	root	_	_
7	2	2	CD	CD	_	11	nummod	_	_
8	mg/kg	mg/kg	NN	NN	_	11	compound	_	_
9	IV	iv	CD	CD	_	11	nummod	_	_
10	bolus	bolus	NN	NN	_	11	compound	_	_
11	doses	dose	NNS	NNS	_	6	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	liposomal	liposomal	JJ	JJ	_	14	amod	_	_
14	MPL	mpl	NN	NN	_	11	nmod	_	_
15	compared	compare	VBN	VBN	_	17	case	_	_
16	to	to	TO	TO	_	17	case	_	_
17	drug	drug	NN	NN	_	6	advcl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	solution	solution	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Animals	animal	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	sacrificed	sacrifice	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	various	various	JJ	JJ	_	6	amod	_	_
6	times	time	NNS	NNS	_	3	nmod	_	_
7	post-dosing	post-dosing	JJ	JJ	_	6	amod	_	_
8	until	until	IN	IN	_	10	case	_	_
9	120	120	CD	CD	_	10	nummod	_	_
10	h	h	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	spleen	spleen	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	excised	excise	VBN	VBN	_	3	conj	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	,	,	,	,	_	3	punct	_	_
17	after	after	IN	IN	_	18	case	_	_
18	incubation	incubation	NN	NN	_	28	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	PHA	pha	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	28	punct	_	_
24	splenocyte	splenocyte	NN	NN	_	26	compound	_	_
25	blastogenic	blastogenic	JJ	JJ	_	26	amod	_	_
26	responses	response	NNS	NNS	_	28	nsubjpass	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	assessed	assess	VBN	VBN	_	3	conj	_	_
29	by	by	IN	IN	_	30	mark	_	_
30	measuring	measure	VBG	VBG	_	28	advcl	_	_
31	cellular	cellular	JJ	JJ	_	32	amod	_	_
32	incorporation	incorporation	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	3H-thymidine	3h-thymidine	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	suppressive	suppressive	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	liposomal	liposomal	JJ	JJ	_	6	amod	_	_
6	MPL	mpl	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	comparison	comparison	NN	NN	_	14	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	free	free	JJ	JJ	_	11	amod	_	_
11	drug	drug	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	prolonged	prolonged	JJ	JJ	_	0	root	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	&gt;	&gt;	JJR	JJR	_	14	dep	_	_
17	120	120	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	16	dep	_	_
19	vs	vs	CC	CC	_	16	cc	_	_
20	&lt;	&lt;	JJR	JJR	_	16	conj	_	_
21	18	18	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	20	dep	_	_
23	)	)	-RRB-	-RRB-	_	16	punct	_	_
24	.	.	.	.	_	14	punct	_	_

1	Inhibition	inhibition	NN	NN	_	2	compound	_	_
2	effects	effect	NNS	NNS	_	6	nsubjpass	_	_
3	versus	versus	CC	CC	_	2	cc	_	_
4	time	time	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	described	describe	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	pharmacodynamic	pharmacodynamic	JJ	JJ	_	10	amod	_	_
10	model	model	NN	NN	_	6	nmod	_	_
11	using	use	VBG	VBG	_	6	xcomp	_	_
12	MPL	mpl	NN	NN	_	13	compound	_	_
13	concentrations	concentration	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	plasma	plasma	NN	NN	_	13	nmod	_	_
16	as	as	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	input	input	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	nonlinear	nonlinear	JJ	JJ	_	3	amod	_	_
3	relationship	relationship	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	between	between	IN	IN	_	7	case	_	_
7	suppression	suppression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	splenocyte	splenocyte	NN	NN	_	10	compound	_	_
10	proliferation	proliferation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	concentration	concentration	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	bound	bind	VBN	VBN	_	17	amod	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	spleen	spleen	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Only	only	RB	RB	_	4	advmod	_	_
2	partial	partial	JJ	JJ	_	4	amod	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	occupancy	occupancy	NN	NN	_	5	nsubj	_	_
5	accompanied	accompany	VBD	VBD	_	0	root	_	_
6	complete	complete	JJ	JJ	_	8	amod	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	suppression	suppression	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	suppression	suppression	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	endogenous	endogenous	JJ	JJ	_	5	amod	_	_
5	corticosterone	corticosterone	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	plasma	plasma	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	both	both	DT	DT	_	10	det	_	_
10	treatments	treatment	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	similar	similar	JJ	JJ	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	values	value	NNS	NNS	_	12	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	L-MPL	l-mpl	NN	NN	_	17	compound	_	_
17	rats	rat	NNS	NNS	_	14	nmod	_	_
18	returning	return	VBG	VBG	_	14	acl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	baseline	baseline	NN	NN	_	18	nmod	_	_
21	after	after	IN	IN	_	23	case	_	_
22	24	24	CD	CD	_	23	nummod	_	_
23	h	h	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	enhanced	enhance	VBN	VBN	_	5	amod	_	_
5	efficacy	efficacy	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	local	local	JJ	JJ	_	8	amod	_	_
8	immunosuppression	immunosuppression	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	targeting	target	VBG	VBG	_	8	acl	_	_
11	spleen	spleen	NN	NN	_	10	dobj	_	_
12	with	with	IN	IN	_	14	case	_	_
13	liposomal	liposomal	JJ	JJ	_	14	amod	_	_
14	MPL	mpl	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Arrested	arrest	VBN	VBN	_	2	amod	_	_
2	development	development	NN	NN	_	0	root	_	_
3	:	:	:	:	_	2	punct	_	_
4	understanding	understand	VBG	VBG	_	2	dep	_	_
5	v-abl	v-abl	NN	NN	_	4	dobj	_	_
6	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	protein	protein	NN	NN	_	4	compound	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	v-abl	v-abl	NN	NN	_	9	compound	_	_
9	oncogene	oncogene	NN	NN	_	5	nmod	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	subvert	subvert	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	19	det	_	_
16	normal	normal	JJ	JJ	_	19	amod	_	_
17	second	second	JJ	JJ	_	16	dep	_	_
18	messenger	messenger	NN	NN	_	19	compound	_	_
19	systems	system	NNS	NNS	_	14	dobj	_	_
20	used	use	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	growth	growth	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	differentiation	differentiation	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	12	punct	_	_

1	Transformation	transformation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	bone	bone	NN	NN	_	4	compound	_	_
4	marrow	marrow	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	Abelson	abelson	NN	NN	_	10	compound	_	_
8	murine	murine	NN	NN	_	10	compound	_	_
9	leukemia	leukemia	NN	NN	_	10	compound	_	_
10	virus	virus	NN	NN	_	1	nmod	_	_
11	results	result	VBZ	VBZ	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	appearance	appearance	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	B	b	NN	NN	_	19	compound	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	lineage	lineage	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	arrested	arrest	VBN	VBN	_	19	acl	_	_
21	at	at	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	pre-B	pre-b	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	stage	stage	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	these	these	DT	DT	_	6	det	_	_
6	cells	cell	NNS	NNS	_	4	dobj	_	_
7	expressing	express	VBG	VBG	_	6	acl	_	_
8	high	high	JJ	JJ	_	11	amod	_	_
9	v-abl	v-abl	NN	NN	_	11	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	dobj	_	_
12	as	as	IN	IN	_	13	case	_	_
13	deficient	deficient	JJ	JJ	_	4	advcl	_	_
14	in	in	IN	IN	_	19	case	_	_
15	detectable	detectable	JJ	JJ	_	19	amod	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	low	low	JJ	JJ	_	25	amod	_	_
22	level	level	NN	NN	_	25	compound	_	_
23	RAG	rag	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	19	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	v-abl	v-abl	NN	NN	_	8	nsubj	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	aux	_	_
8	inhibiting	inhibit	VBG	VBG	_	3	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	differentiation	differentiation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	blocking	block	VBG	VBG	_	8	advcl	_	_
16	these	these	DT	DT	_	19	det	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	crucial	crucial	JJ	JJ	_	19	amod	_	_
19	elements	element	NNS	NNS	_	15	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	maturation	maturation	NN	NN	_	23	compound	_	_
23	pathway	pathway	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	MHC	mhc	NN	NN	_	2	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	2	nummod	_	_
4	signaling	signaling	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	B-cell	b-cell	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	-LSB-	-lsb-	-LRB-	-LRB-	_	9	punct	_	_
9	see	see	VB	VB	_	4	dep	_	_
10	comments	comment	NNS	NNS	_	9	dobj	_	_
11	-RSB-	-rsb-	-RRB-	-RRB-	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cognate	cognate	JJ	JJ	_	3	amod	_	_
3	interaction	interaction	NN	NN	_	26	nsubj	_	_
4	between	between	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	antigen-presenting	antigen-presenting	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	APCs	apc	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	3	punct	_	_
14	mediated	mediate	VBN	VBN	_	3	acl	_	_
15	by	by	IN	IN	_	24	case	_	_
16	major	major	JJ	JJ	_	24	amod	_	_
17	histocompatibility	histocompatibility	NN	NN	_	24	compound	_	_
18	complex	complex	NN	NN	_	24	compound	_	_
19	(	(	-LRB-	-LRB-	_	24	punct	_	_
20	MHC	mhc	NN	NN	_	24	compound	_	_
21	)	)	-RRB-	-RRB-	_	24	punct	_	_
22	class	class	NN	NN	_	24	compound	_	_
23	II	ii	CD	CD	_	24	nummod	_	_
24	molecules	molecule	NNS	NNS	_	14	nmod	_	_
25	,	,	,	,	_	3	punct	_	_
26	results	result	VBZ	VBZ	_	0	root	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	delivery	delivery	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	activation	activation	NN	NN	_	32	compound	_	_
32	signals	signal	NNS	NNS	_	29	nmod	_	_
33	to	to	TO	TO	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	APC	apc	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	26	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	signals	signal	NNS	NNS	_	3	nsubj	_	_
3	contribute	contribute	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	co-stimulatory	co-stimulatory	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	APCs	apc	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	have	have	VBP	VBP	_	3	conj	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	consequences	consequence	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	effector	effector	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	MHC	mhc	NN	NN	_	2	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	2	nummod	_	_
4	molecules	molecule	NNS	NNS	_	6	nsubj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	serve	serve	VBP	VBP	_	0	root	_	_
7	as	as	IN	IN	_	8	case	_	_
8	receptors	receptor	NNS	NNS	_	6	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	stimulation	stimulation	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	microbial	microbial	JJ	JJ	_	14	amod	_	_
14	superantigens	superantigen	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	Paul	paul	NN	NN	_	6	compound	_	_
6	Scholl	scholl	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Raif	raif	NN	NN	_	9	compound	_	_
9	Geha	geha	NN	NN	_	6	conj	_	_
10	discuss	discuss	VBP	VBP	_	0	root	_	_
11	recent	recent	JJ	JJ	_	12	amod	_	_
12	advances	advance	NNS	NNS	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	our	we	PRP$	PRP$	_	15	nmod:poss	_	_
15	understanding	understanding	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	mechanisms	mechanism	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	MHC	mhc	NN	NN	_	20	compound	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	20	nummod	_	_
22	signaling	signaling	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	analyse	analyse	VBP	VBP	_	10	conj	_	_
25	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
26	role	role	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	B-cell	b-cell	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	gene	gene	NN	NN	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	transcripts	transcript	NNS	NNS	_	2	appos	_	_
6	:	:	:	:	_	2	punct	_	_
7	isolation	isolation	NN	NN	_	2	dep	_	_
8	of	of	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	alternative	alternative	JJ	JJ	_	11	amod	_	_
11	transcript	transcript	NN	NN	_	7	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	autoantigen	autoantigen	NN	NN	_	16	compound	_	_
16	La/SS-B	la/ss-b	NN	NN	_	12	nmod	_	_
17	from	from	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	cDNA	cdna	NN	NN	_	20	compound	_	_
20	library	library	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	patient	patient	NN	NN	_	20	nmod	_	_
24	with	with	IN	IN	_	28	case	_	_
25	primary	primary	JJ	JJ	_	28	amod	_	_
26	Sjogrens	sjogrens	NN	NN	_	28	nmod:poss	_	_
27	'	'	POS	POS	_	28	case	_	_
28	syndrome	syndrome	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	library	library	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	prepared	prepare	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	8	case	_	_
7	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
8	blood	blood	NN	NN	_	5	nmod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	8	dep	_	_
10	of	of	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	autoimmune	autoimmune	JJ	JJ	_	13	amod	_	_
13	patient	patient	NN	NN	_	8	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	primary	primary	JJ	JJ	_	18	amod	_	_
16	Sjogrens	sjogrens	NN	NN	_	18	nmod:poss	_	_
17	'	'	POS	POS	_	18	case	_	_
18	syndrome	syndrome	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	library	library	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	screened	screen	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	11	det	_	_
8	patients	patient	NNS	NNS	_	11	compound	_	_
9	own	own	JJ	JJ	_	11	amod	_	_
10	autoimmune	autoimmune	JJ	JJ	_	9	dep	_	_
11	serum	serum	NN	NN	_	13	nsubj	_	_
12	being	be	VBG	VBG	_	13	cop	_	_
13	monospecific	monospecific	JJ	JJ	_	5	advcl	_	_
14	for	for	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	autoantigen	autoantigen	NN	NN	_	18	compound	_	_
18	La/SS-B	la/ss-b	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Thereby	thereby	RB	RB	_	9	advmod	_	_
2	an	a	DT	DT	_	4	det	_	_
3	alternative	alternative	JJ	JJ	_	4	amod	_	_
4	type	type	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	La	la	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	identified	identify	VBN	VBN	_	0	root	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	differed	differ	VBD	VBD	_	9	dep	_	_
12	from	from	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	known	known	JJ	JJ	_	16	amod	_	_
15	La	la	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	11	nmod	_	_
17	due	due	JJ	JJ	_	11	xcomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	an	a	DT	DT	_	20	det	_	_
20	exchange	exchange	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	exon	exon	NN	NN	_	20	nmod	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Sequencing	sequencing	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	genomic	genomic	JJ	JJ	_	5	amod	_	_
5	region	region	NN	NN	_	1	nmod	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	exons	exon	NNS	NNS	_	5	nmod	_	_
9	1	1	CD	CD	_	8	dep	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	2	2	CD	CD	_	8	conj	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	alternative	alternative	JJ	JJ	_	16	amod	_	_
16	5'-end	5'-end	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	a	a	DT	DT	_	19	det	_	_
19	part	part	NN	NN	_	12	ccomp	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	intron	intron	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	23	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	alternative	alternative	JJ	JJ	_	10	amod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	exists	exist	VBZ	VBZ	_	10	acl:relcl	_	_
14	within	within	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	intron	intron	NN	NN	_	13	nmod	_	_
17	downstream	downstream	JJ	JJ	_	16	advmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	exon	exon	NN	NN	_	17	nmod	_	_
21	1	1	CD	CD	_	20	nummod	_	_
22	,	,	,	,	_	5	punct	_	_
23	became	become	VBD	VBD	_	0	root	_	_
24	evident	evident	JJ	JJ	_	23	xcomp	_	_
25	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	consequence	consequence	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	alternative	alternative	JJ	JJ	_	7	amod	_	_
6	La	la	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	10	nsubj	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	the	the	DT	DT	_	10	det	_	_
10	result	result	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	switching	switching	NN	NN	_	10	nmod	_	_
15	combined	combine	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	alternative	alternative	JJ	JJ	_	20	amod	_	_
19	splicing	splicing	NN	NN	_	20	compound	_	_
20	mechanism	mechanism	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	intron	intron	NN	NN	_	18	nmod	_	_
4	,	,	,	,	_	18	punct	_	_
5	further	further	JJ	JJ	_	9	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	18	nsubjpass	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	identified	identify	VBN	VBN	_	0	root	_	_
19	leading	lead	VBG	VBG	_	18	xcomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	suggestion	suggestion	NN	NN	_	19	nmod	_	_
23	that	that	IN	IN	_	35	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	35	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	gene	gene	NN	NN	_	25	nmod	_	_
29	encoding	encode	VBG	VBG	_	28	acl	_	_
30	for	for	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
33	autoantigen	autoantigen	NN	NN	_	34	compound	_	_
34	La/SS-B	la/ss-b	NN	NN	_	29	nmod	_	_
35	alters	alter	VBZ	VBZ	_	22	ccomp	_	_
36	in	in	IN	IN	_	37	case	_	_
37	dependence	dependence	NN	NN	_	35	nmod	_	_
38	on	on	IN	IN	_	40	case	_	_
39	disease	disease	NN	NN	_	40	compound	_	_
40	conditions	condition	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	18	punct	_	_

1	Functional	functional	JJ	JJ	_	3	amod	_	_
2	Myc-Max	myc-max	NN	NN	_	3	compound	_	_
3	heterodimer	heterodimer	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	activation-induced	activation-induced	JJ	JJ	_	8	amod	_	_
8	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	hybridomas	hybridoma	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	hybridomas	hybridoma	NNS	NNS	_	4	nsubj	_	_
4	respond	respond	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	activation	activation	NN	NN	_	7	compound	_	_
7	signals	signal	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	undergoing	undergo	VBG	VBG	_	4	advcl	_	_
10	apoptotic	apoptotic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	death	death	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	this	this	DT	DT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	likely	likely	RB	RB	_	4	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	represent	represent	VB	VB	_	17	xcomp	_	_
20	comparable	comparable	JJ	JJ	_	21	amod	_	_
21	events	event	NNS	NNS	_	19	dobj	_	_
22	related	related	JJ	JJ	_	21	amod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	tolerance	tolerance	NN	NN	_	25	compound	_	_
25	induction	induction	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	immature	immature	JJ	JJ	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	mature	mature	JJ	JJ	_	27	conj	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	dep	_	_
32	in	in	FW	FW	_	33	compound	_	_
33	vivo	vivo	FW	FW	_	27	advmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	6	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	antisense	antisense	JJ	JJ	_	5	amod	_	_
5	oligonucleotides	oligonucleotide	NNS	NNS	_	3	dobj	_	_
6	implicated	implicate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	c-Myc	c-myc	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	phenomenon	phenomenon	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	activation-induced	activation-induced	JJ	JJ	_	15	amod	_	_
15	apoptosis	apoptosis	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	9	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	c-Myc	c-myc	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	now	now	RB	RB	_	9	advmod	_	_
9	confirmed	confirm	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	studies	study	NNS	NNS	_	9	nmod	_	_
12	using	use	VBG	VBG	_	11	acl	_	_
13	a	a	DT	DT	_	16	det	_	_
14	dominant	dominant	JJ	JJ	_	16	dep	_	_
15	negative	negative	JJ	JJ	_	16	dep	_	_
16	form	form	NN	NN	_	12	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
19	heterodimeric	heterodimeric	JJ	JJ	_	21	amod	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	partner	partner	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	Max	max	NN	NN	_	16	appos	_	_
24	,	,	,	,	_	16	punct	_	_
25	which	which	WDT	WDT	_	27	dobj	_	_
26	we	we	PRP	PRP	_	27	nsubj	_	_
27	show	show	VBP	VBP	_	16	acl:relcl	_	_
28	here	here	RB	RB	_	27	advmod	_	_
29	inhibits	inhibit	VBZ	VBZ	_	27	ccomp	_	_
30	activation-induced	activation-induced	JJ	JJ	_	31	amod	_	_
31	apoptosis	apoptosis	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	9	punct	_	_

1	Further	further	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	coexpression	coexpression	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	reciprocally	reciprocally	RB	RB	_	9	advmod	_	_
7	mutant	mutant	JJ	JJ	_	9	amod	_	_
8	Myc	myc	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	3	nmod	_	_
10	capable	capable	JJ	JJ	_	9	amod	_	_
11	of	of	IN	IN	_	12	mark	_	_
12	forming	form	VBG	VBG	_	10	advcl	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	heterodimers	heterodimer	NNS	NNS	_	12	dobj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	mutant	mutant	JJ	JJ	_	18	amod	_	_
18	Max	max	NN	NN	_	12	nmod	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	compensate	compensate	VB	VB	_	0	root	_	_
21	for	for	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	dominant	dominant	JJ	JJ	_	25	amod	_	_
24	negative	negative	JJ	JJ	_	23	dep	_	_
25	activity	activity	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	restore	restore	VB	VB	_	20	conj	_	_
28	activation-induced	activation-induced	JJ	JJ	_	29	amod	_	_
29	apoptosis	apoptosis	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Myc	myc	NN	NN	_	6	nsubj	_	_
6	promotes	promote	VBZ	VBZ	_	3	ccomp	_	_
7	activation-induced	activation-induced	JJ	JJ	_	8	amod	_	_
8	apoptosis	apoptosis	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	11	case	_	_
10	obligatory	obligatory	JJ	JJ	_	11	amod	_	_
11	heterodimerization	heterodimerization	NN	NN	_	6	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Max	max	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	therefore	therefore	RB	RB	_	11	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	regulating	regulate	VBG	VBG	_	11	conj	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	15	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	regulates	regulate	VBZ	VBZ	_	2	acl:relcl	_	_
5	the	the	DT	DT	_	11	det	_	_
6	class	class	NN	NN	_	11	compound	_	_
7	II	ii	CD	CD	_	11	nummod	_	_
8	major	major	JJ	JJ	_	11	amod	_	_
9	histocompatibility	histocompatibility	NN	NN	_	11	compound	_	_
10	complex	complex	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	4	dobj	_	_
12	DPA	dpa	NN	NN	_	11	dep	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	a	a	DT	DT	_	15	det	_	_
15	member	member	NN	NN	_	0	root	_	_
16	of	of	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	subfamily	subfamily	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	zinc	zinc	NN	NN	_	22	compound	_	_
21	finger	finger	NN	NN	_	22	compound	_	_
22	proteins	protein	NNS	NNS	_	18	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	includes	include	VBZ	VBZ	_	18	acl:relcl	_	_
25	a	a	DT	DT	_	29	det	_	_
26	Drosophila	drosophila	FW	FW	_	29	compound	_	_
27	developmental	developmental	JJ	JJ	_	29	amod	_	_
28	control	control	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	24	dobj	_	_
30	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	DNA	dna	NN	NN	_	5	compound	_	_
4	sequence	sequence	NN	NN	_	5	compound	_	_
5	element	element	NN	NN	_	24	nsubjpass	_	_
6	termed	term	VBN	VBN	_	5	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	J	j	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	6	xcomp	_	_
10	involved	involve	VBN	VBN	_	5	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	regulated	regulate	VBN	VBN	_	14	amod	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	class	class	NN	NN	_	21	compound	_	_
17	II	ii	CD	CD	_	21	nummod	_	_
18	major	major	JJ	JJ	_	21	amod	_	_
19	histocompatibility	histocompatibility	NN	NN	_	21	compound	_	_
20	complex	complex	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	14	nmod	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	recently	recently	RB	RB	_	24	advmod	_	_
24	described	describe	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	element	element	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
7	role	role	NN	NN	_	4	conj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	regulation	regulation	NN	NN	_	7	nmod	_	_
13	further	further	RB	RB	_	2	advmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	cDNA	cdna	NN	NN	_	17	compound	_	_
17	library	library	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	screened	screen	VBN	VBN	_	2	parataxis	_	_
20	with	with	IN	IN	_	22	case	_	_
21	oligonucleotide	oligonucleotide	NN	NN	_	22	compound	_	_
22	probes	probe	NNS	NNS	_	19	nmod	_	_
23	containing	contain	VBG	VBG	_	22	acl	_	_
24	both	both	CC	CC	_	27	cc:preconj	_	_
25	the	the	DT	DT	_	27	det	_	_
26	S	s	NN	NN	_	27	compound	_	_
27	element	element	NN	NN	_	23	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	the	the	DT	DT	_	32	det	_	_
30	nearby	nearby	JJ	JJ	_	32	amod	_	_
31	J	j	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	27	conj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	human	human	JJ	JJ	_	37	amod	_	_
36	DPA	dpa	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	27	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	obtained	obtain	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	procedure	procedure	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	one	one	CD	CD	_	18	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	10	nmod	_	_
13	,	,	,	,	_	18	punct	_	_
14	clone	clone	NN	NN	_	18	nsubjpass	_	_
15	18	18	CD	CD	_	14	nummod	_	_
16	,	,	,	,	_	18	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	reported	report	VBN	VBN	_	5	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	characterized	characterize	VBN	VBN	_	18	conj	_	_
21	here	here	RB	RB	_	18	advmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	protein	protein	NN	NN	_	2	dobj	_	_
5	predicted	predict	VBN	VBN	_	4	acl	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	contain	contain	VB	VB	_	5	xcomp	_	_
8	688	688	CD	CD	_	11	nummod	_	_
9	amino	amino	NN	NN	_	11	compound	_	_
10	acid	acid	NN	NN	_	11	compound	_	_
11	residues	residue	NNS	NNS	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	including	include	VBG	VBG	_	17	case	_	_
14	11	11	CD	CD	_	17	nummod	_	_
15	zinc	zinc	NN	NN	_	17	compound	_	_
16	finger	finger	NN	NN	_	17	compound	_	_
17	motifs	motif	NNS	NNS	_	11	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	C2H2	c2h2	NN	NN	_	21	compound	_	_
21	type	type	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	C-terminal	c-terminal	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	Kruppel-like	kruppel-like	JJ	JJ	_	17	acl:relcl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	conservation	conservation	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	H/C	h/c	NN	NN	_	37	compound	_	_
36	link	link	NN	NN	_	37	compound	_	_
37	sequence	sequence	NN	NN	_	32	nmod	_	_
38	connecting	connect	VBG	VBG	_	37	acl	_	_
39	them	they	PRP	PRP	_	38	dobj	_	_
40	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	160	160	CD	CD	_	5	nummod	_	_
3	N-terminal	n-terminal	JJ	JJ	_	5	amod	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	15	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nonfinger	nonfinger	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	clone	clone	NN	NN	_	9	nmod	_	_
12	18	18	CD	CD	_	11	nummod	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	highly	highly	RB	RB	_	15	advmod	_	_
15	homologous	homologous	JJ	JJ	_	0	root	_	_
16	with	with	IN	IN	_	18	case	_	_
17	similar	similar	JJ	JJ	_	18	amod	_	_
18	regions	region	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	several	several	JJ	JJ	_	21	amod	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	human	human	JJ	JJ	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	mouse	mouse	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	Drosophila	drosophila	FW	FW	_	22	conj	_	_
28	sequences	sequence	NNS	NNS	_	22	dep	_	_
29	,	,	,	,	_	15	punct	_	_
30	defining	define	VBG	VBG	_	15	xcomp	_	_
31	a	a	DT	DT	_	32	det	_	_
32	subfamily	subfamily	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	Kruppel-like	kruppel-like	JJ	JJ	_	37	amod	_	_
35	zinc	zinc	NN	NN	_	37	compound	_	_
36	finger	finger	NN	NN	_	37	compound	_	_
37	proteins	protein	NNS	NNS	_	32	nmod	_	_
38	termed	term	VBN	VBN	_	37	acl	_	_
39	TAB	tab	NN	NN	_	38	xcomp	_	_
40	(	(	-LRB-	-LRB-	_	46	punct	_	_
41	tramtrack	tramtrack	NN	NN	_	46	compound	_	_
42	-LSB-	-lsb-	-LRB-	-LRB-	_	46	punct	_	_
43	ttk	ttk	NN	NN	_	46	compound	_	_
44	-RSB-	-rsb-	-RRB-	-RRB-	_	46	punct	_	_
45	-associated	-associated	JJ	JJ	_	46	amod	_	_
46	box	box	NN	NN	_	39	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	here	here	RB	RB	_	39	advmod	_	_
49	.	.	.	.	_	15	punct	_	_

1	One	one	CD	CD	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Drosophila	drosophila	FW	FW	_	5	compound	_	_
5	sequences	sequence	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	ttk	ttk	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	1	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	developmental	developmental	JJ	JJ	_	13	amod	_	_
12	control	control	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	while	while	IN	IN	_	20	mark	_	_
16	a	a	DT	DT	_	17	det	_	_
17	second	second	JJ	JJ	_	20	nsubj	_	_
18	does	do	VBZ	VBZ	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	contain	contain	VB	VB	_	13	advcl	_	_
21	a	a	DT	DT	_	24	det	_	_
22	zinc	zinc	NN	NN	_	24	compound	_	_
23	finger	finger	NN	NN	_	24	compound	_	_
24	region	region	NN	NN	_	20	dobj	_	_
25	but	but	CC	CC	_	20	cc	_	_
26	encodes	encode	VBZ	VBZ	_	20	conj	_	_
27	a	a	DT	DT	_	28	det	_	_
28	structure	structure	NN	NN	_	26	dobj	_	_
29	important	important	JJ	JJ	_	28	amod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	oocyte	oocyte	NN	NN	_	32	compound	_	_
32	development	development	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	13	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	acidic	acidic	JJ	JJ	_	4	amod	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	domain	domain	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	located	located	JJ	JJ	_	0	root	_	_
7	between	between	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
10	conserved	conserved	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	clone	clone	NN	NN	_	11	nmod	_	_
14	18	18	CD	CD	_	13	nummod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	zinc	zinc	NN	NN	_	18	compound	_	_
18	fingers	finger	NNS	NNS	_	11	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	require	require	VB	VB	_	3	xcomp	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	S	s	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	J	j	NN	NN	_	8	conj	_	_
11	elements	element	NNS	NNS	_	8	dep	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	separated	separate	VBN	VBN	_	8	acl:relcl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	10	10	CD	CD	_	18	nummod	_	_
18	bp	bp	NN	NN	_	15	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	optimal	optimal	JJ	JJ	_	21	amod	_	_
21	binding	binding	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Antisense	antisense	JJ	JJ	_	2	amod	_	_
2	cDNA	cdna	NN	NN	_	6	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	clone	clone	NN	NN	_	2	nmod	_	_
5	18	18	CD	CD	_	4	nummod	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	construct	construct	NN	NN	_	8	nmod	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	DPA	dpa	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	6	punct	_	_
18	indicating	indicate	VBG	VBG	_	6	advcl	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	functional	functional	JJ	JJ	_	21	amod	_	_
21	importance	importance	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	this	this	DT	DT	_	29	det	_	_
27	class	class	NN	NN	_	29	compound	_	_
28	II	ii	CD	CD	_	29	nummod	_	_
29	gene	gene	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	Prevalence	prevalence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	aneuploidy	aneuploidy	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	overexpressed	overexpressed	JJ	JJ	_	6	amod	_	_
6	ER	er	NN	NN	_	3	conj	_	_
7	,	,	,	,	_	3	punct	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	overexpressed	overexpressed	JJ	JJ	_	10	amod	_	_
10	EGFR	egfr	NN	NN	_	3	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	random	random	JJ	JJ	_	14	amod	_	_
13	breast	breast	NN	NN	_	14	compound	_	_
14	aspirates	aspirate	NNS	NNS	_	3	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	women	woman	NNS	NNS	_	14	nmod	_	_
17	at	at	IN	IN	_	21	case	_	_
18	high	high	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	low	low	JJ	JJ	_	18	conj	_	_
21	risk	risk	NN	NN	_	16	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	breast	breast	NN	NN	_	24	compound	_	_
24	cancer	cancer	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Breast	breast	NN	NN	_	3	compound	_	_
2	tissue	tissue	NN	NN	_	3	compound	_	_
3	biomarkers	biomarker	NNS	NNS	_	20	nsubj	_	_
4	which	which	WDT	WDT	_	6	nsubj	_	_
5	accurately	accurately	RB	RB	_	6	advmod	_	_
6	predict	predict	VBP	VBP	_	3	acl:relcl	_	_
7	breast	breast	NN	NN	_	9	compound	_	_
8	cancer	cancer	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	6	dobj	_	_
10	within	within	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	10	10	CD	CD	_	13	compound	_	_
13	year	year	NN	NN	_	14	amod	_	_
14	period	period	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	high	high	JJ	JJ	_	17	dep	_	_
17	risk	risk	NN	NN	_	18	amod	_	_
18	women	woman	NNS	NNS	_	9	nmod	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	needed	need	VBN	VBN	_	0	root	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	currently	currently	RB	RB	_	24	advmod	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	available	available	JJ	JJ	_	20	conj	_	_
25	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	initiated	initiate	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	determine	determine	VB	VB	_	2	advcl	_	_
7	1	1	LS	LS	_	10	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	prevalence	prevalence	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	17	case	_	_
12	one	one	CD	CD	_	17	nummod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	more	more	JJR	JJR	_	12	conj	_	_
15	breast	breast	NN	NN	_	17	compound	_	_
16	tissue	tissue	NN	NN	_	17	compound	_	_
17	abnormalities	abnormality	NNS	NNS	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	group	group	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	women	woman	NNS	NNS	_	20	nmod	_	_
23	at	at	IN	IN	_	25	case	_	_
24	high	high	JJ	JJ	_	25	amod	_	_
25	risk	risk	NN	NN	_	22	nmod	_	_
26	for	for	IN	IN	_	28	case	_	_
27	breast	breast	NN	NN	_	28	compound	_	_
28	cancer	cancer	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	10	punct	_	_
30	and	and	CC	CC	_	10	cc	_	_
31	2	2	LS	LS	_	40	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	if	if	IN	IN	_	40	mark	_	_
34	the	the	DT	DT	_	35	det	_	_
35	prevalence	prevalence	NN	NN	_	40	nsubj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	biomarker	biomarker	NN	NN	_	38	compound	_	_
38	abnormalities	abnormality	NNS	NNS	_	35	nmod	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	greater	greater	JJR	JJR	_	10	conj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	high	high	JJ	JJ	_	43	amod	_	_
43	risk	risk	NN	NN	_	40	nmod	_	_
44	than	than	IN	IN	_	48	case	_	_
45	in	in	IN	IN	_	48	case	_	_
46	low	low	JJ	JJ	_	48	amod	_	_
47	risk	risk	NN	NN	_	48	compound	_	_
48	women	woman	NNS	NNS	_	40	advcl	_	_
49	.	.	.	.	_	2	punct	_	_

1	Eligible	eligible	JJ	JJ	_	4	amod	_	_
2	high	high	JJ	JJ	_	4	amod	_	_
3	risk	risk	NN	NN	_	4	compound	_	_
4	women	woman	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	those	those	DT	DT	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	first	first	JJ	JJ	_	10	dep	_	_
10	degree	degree	NN	NN	_	11	amod	_	_
11	relative	relative	NN	NN	_	6	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	breast	breast	NN	NN	_	14	compound	_	_
14	cancer	cancer	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	prior	prior	JJ	JJ	_	18	amod	_	_
17	breast	breast	NN	NN	_	18	compound	_	_
18	cancer	cancer	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	or	or	CC	CC	_	14	cc	_	_
21	precancerous	precancerous	JJ	JJ	_	22	amod	_	_
22	mastopathy	mastopathy	NN	NN	_	14	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Low	low	JJ	JJ	_	3	amod	_	_
2	risk	risk	NN	NN	_	3	compound	_	_
3	women	woman	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	those	those	DT	DT	_	0	root	_	_
6	without	without	IN	IN	_	7	case	_	_
7	these	these	DT	DT	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	other	other	JJ	JJ	_	13	amod	_	_
10	major	major	JJ	JJ	_	13	amod	_	_
11	identifiable	identifiable	JJ	JJ	_	13	amod	_	_
12	risk	risk	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	7	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Ductal	ductal	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	via	via	IN	IN	_	9	case	_	_
6	random	random	JJ	JJ	_	9	amod	_	_
7	fine	fine	JJ	JJ	_	9	amod	_	_
8	needle	needle	NN	NN	_	9	compound	_	_
9	aspirations	aspiration	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	cytologically	cytologically	RB	RB	_	12	advmod	_	_
12	classified	classify	VBN	VBN	_	4	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Biomarkers	biomarker	NNS	NNS	_	2	nsubj	_	_
2	included	include	VBD	VBD	_	0	root	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	ploidy	ploidy	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	estrogen	estrogen	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	ER	er	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	epidermal	epidermal	JJ	JJ	_	16	amod	_	_
14	growth	growth	NN	NN	_	16	compound	_	_
15	factor	factor	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	4	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	EGFR	egfr	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	prevalence	prevalence	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	aneuploidy	aneuploidy	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	30	30	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	overexpression	overexpression	NN	NN	_	14	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ER	er	NN	NN	_	10	nmod	_	_
13	10	10	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	8	ccomp	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	overexpression	overexpression	NN	NN	_	21	dep	_	_
18	of	of	IN	IN	_	19	case	_	_
19	EGFR	egfr	NN	NN	_	17	nmod	_	_
20	35	35	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	8	conj	_	_
22	,	,	,	,	_	8	punct	_	_
23	in	in	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	206	206	CD	CD	_	28	nummod	_	_
26	high	high	JJ	JJ	_	28	amod	_	_
27	risk	risk	NN	NN	_	28	compound	_	_
28	women	woman	NNS	NNS	_	8	nmod	_	_
29	whose	whose	WP$	WP$	_	33	nmod:poss	_	_
30	median	median	JJ	JJ	_	33	amod	_	_
31	10	10	CD	CD	_	32	compound	_	_
32	year	year	NN	NN	_	33	amod	_	_
33	Gail	gail	NN	NN	_	45	nsubj	_	_
34	risk	risk	NN	NN	_	33	dep	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	projected	project	VBN	VBN	_	37	amod	_	_
37	probability	probability	NN	NN	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	of	of	IN	IN	_	40	mark	_	_
40	developing	develop	VBG	VBG	_	33	acl	_	_
41	breast	breast	NN	NN	_	42	compound	_	_
42	cancer	cancer	NN	NN	_	40	dobj	_	_
43	was	be	VBD	VBD	_	45	cop	_	_
44	4.5	4.5	CD	CD	_	45	nummod	_	_
45	%	%	NN	NN	_	28	acl:relcl	_	_
46	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	prevalence	prevalence	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	aneuploidy	aneuploidy	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	overexpressed	overexpressed	JJ	JJ	_	7	amod	_	_
7	EGFR	egfr	NN	NN	_	4	conj	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	higher	higher	JJR	JJR	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	high	high	JJ	JJ	_	15	amod	_	_
14	risk	risk	NN	NN	_	15	compound	_	_
15	women	woman	NNS	NNS	_	10	nmod	_	_
16	than	than	IN	IN	_	22	case	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	25	25	CD	CD	_	22	nummod	_	_
20	low	low	JJ	JJ	_	22	amod	_	_
21	risk	risk	NN	NN	_	22	compound	_	_
22	controls	control	NNS	NNS	_	10	advcl	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	p	p	NN	NN	_	26	dep	_	_
25	&lt;	&lt;	JJR	JJR	_	26	advmod	_	_
26	0.002	0.002	CD	CD	_	22	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	22	punct	_	_
29	whose	whose	WP$	WP$	_	34	nmod:poss	_	_
30	median	median	JJ	JJ	_	34	amod	_	_
31	10	10	CD	CD	_	32	compound	_	_
32	year	year	NN	NN	_	34	amod	_	_
33	Gail	gail	NN	NN	_	34	compound	_	_
34	risk	risk	NN	NN	_	37	nsubj	_	_
35	was	be	VBD	VBD	_	37	cop	_	_
36	0.7	0.7	CD	CD	_	37	nummod	_	_
37	%	%	NN	NN	_	22	acl:relcl	_	_
38	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	18	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	prevalence	prevalence	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	ER	er	NN	NN	_	8	compound	_	_
8	overexpression	overexpression	NN	NN	_	5	nmod	_	_
9	between	between	IN	IN	_	14	case	_	_
10	high	high	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	low	low	JJ	JJ	_	10	conj	_	_
13	risk	risk	NN	NN	_	14	compound	_	_
14	groups	group	NNS	NNS	_	2	nmod	_	_
15	was	be	VBD	VBD	_	18	cop	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	statistically	statistically	RB	RB	_	18	advmod	_	_
18	significant	significant	JJ	JJ	_	0	root	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	p	p	NN	NN	_	21	nsubj	_	_
21	=	=	JJ	JJ	_	18	parataxis	_	_
22	0.095	0.095	CD	CD	_	21	dobj	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	8	nsubj	_	_
2	may	may	MD	MD	_	8	aux	_	_
3	be	be	VB	VB	_	8	cop	_	_
4	due	due	JJ	JJ	_	8	case	_	_
5	to	to	TO	TO	_	4	mwe	_	_
6	the	the	DT	DT	_	8	det	_	_
7	low	low	JJ	JJ	_	8	amod	_	_
8	prevalence	prevalence	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	overexpressed	overexpressed	JJ	JJ	_	11	amod	_	_
11	ER	er	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	small	small	JJ	JJ	_	15	amod	_	_
15	number	number	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	controls	control	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	noted	note	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	prevalence	prevalence	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	one	one	CD	CD	_	14	nummod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	more	more	JJR	JJR	_	10	conj	_	_
13	abnormal	abnormal	JJ	JJ	_	14	amod	_	_
14	biomarkers	biomarker	NNS	NNS	_	8	nmod	_	_
15	between	between	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	risk	risk	NN	NN	_	22	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	low	low	JJ	JJ	_	21	amod	_	_
21	risk	risk	NN	NN	_	18	conj	_	_
22	women	woman	NNS	NNS	_	5	nmod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	p	p	NN	NN	_	26	dep	_	_
25	&lt;	&lt;	JJR	JJR	_	26	advmod	_	_
26	0.001	0.001	CD	CD	_	5	parataxis	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	large	large	JJ	JJ	_	4	amod	_	_
3	prospective	prospective	JJ	JJ	_	4	amod	_	_
4	trial	trial	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	needed	need	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	6	xcomp	_	_
9	if	if	IN	IN	_	18	mark	_	_
10	one	one	CD	CD	_	18	nsubj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	more	more	JJR	JJR	_	10	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	biomarkers	biomarker	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	predictive	predictive	JJ	JJ	_	8	advcl	_	_
19	of	of	IN	IN	_	22	case	_	_
20	breast	breast	NN	NN	_	22	compound	_	_
21	cancer	cancer	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	lymphoid	lymphoid	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	death	death	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	one	one	CD	CD	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	earliest	earliest	JJS	JJS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	most	most	JJS	JJS	_	18	dep	_	_
18	thoroughly	thoroughly	RB	RB	_	15	conj	_	_
19	studied	study	VBN	VBN	_	20	amod	_	_
20	models	model	NNS	NNS	_	15	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	apoptosis	apoptosis	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Although	although	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	exact	exact	JJ	JJ	_	4	amod	_	_
4	mechanism	mechanism	NN	NN	_	12	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	apoptosis	apoptosis	NN	NN	_	8	nsubj	_	_
8	occurs	occur	VBZ	VBZ	_	4	acl:relcl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	unknown	unknown	JJ	JJ	_	20	advcl	_	_
13	many	many	JJ	JJ	_	14	amod	_	_
14	biochemical	biochemical	JJ	JJ	_	20	nsubjpass	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	molecular	molecular	JJ	JJ	_	14	conj	_	_
17	changes	change	NNS	NNS	_	14	dep	_	_
18	have	have	VBP	VBP	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	occur	occur	VB	VB	_	20	xcomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	22	nmod	_	_
28	to	to	TO	TO	_	29	case	_	_
29	glucocorticoids	glucocorticoid	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	chromatin	chromatin	NN	NN	_	5	compound	_	_
5	degradation	degradation	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	endonucleases	endonuclease	NNS	NNS	_	5	conj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	apoptotic	apoptotic	JJ	JJ	_	11	amod	_	_
11	process	process	NN	NN	_	2	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	been	be	VBN	VBN	_	15	auxpass	_	_
14	closely	closely	RB	RB	_	15	advmod	_	_
15	studied	study	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	as	as	RB	RB	_	15	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	the	the	DT	DT	_	21	det	_	_
21	involvement	involvement	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	several	several	JJ	JJ	_	24	amod	_	_
24	oncogenes	oncogene	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lysis	lysis	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	clinical	clinical	JJ	JJ	_	6	amod	_	_
6	importance	importance	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	treatment	treatment	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	lymphoid	lymphoid	JJ	JJ	_	15	amod	_	_
15	neoplasms	neoplasm	NNS	NNS	_	12	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	recently	recently	RB	RB	_	18	advmod	_	_
18	received	receive	VBN	VBN	_	0	root	_	_
19	increased	increase	VBN	VBN	_	20	amod	_	_
20	attention	attention	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	18	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	evidence	evidence	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	progesterone	progesterone	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
14	during	during	IN	IN	_	15	case	_	_
15	pregnancy	pregnancy	NN	NN	_	5	nmod	_	_
16	-LSB-	-lsb-	-LRB-	-LRB-	_	17	punct	_	_
17	see	see	VB	VB	_	2	dep	_	_
18	comments	comment	NNS	NNS	_	17	dobj	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	progesterone	progesterone	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	analysed	analyse	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	using	use	VBG	VBG	_	13	advcl	_	_
16	an	a	DT	DT	_	20	det	_	_
17	enzyme	enzyme	NN	NN	_	20	compound	_	_
18	linked	linked	JJ	JJ	_	20	amod	_	_
19	immunosorbent	immunosorbent	JJ	JJ	_	20	amod	_	_
20	assay	assay	NN	NN	_	15	dobj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	Abbott	abbott	NN	NN	_	23	compound	_	_
23	PgR-EIA	pgr-eia	NN	NN	_	20	appos	_	_
24	monoclonal	monoclonal	JJ	JJ	_	23	amod	_	_
25	)	)	-RRB-	-RRB-	_	23	punct	_	_
26	,	,	,	,	_	13	punct	_	_
27	in	in	IN	IN	_	30	mark	_	_
28	order	order	NN	NN	_	27	mwe	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	evaluate	evaluate	VB	VB	_	13	advcl	_	_
31	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
32	prognostic	prognostic	JJ	JJ	_	33	amod	_	_
33	character	character	NN	NN	_	30	dobj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	context	context	NN	NN	_	30	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	spontaneous	spontaneous	JJ	JJ	_	39	amod	_	_
39	abortion	abortion	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	13	punct	_	_

1	Cytosols	cytosol	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	prepared	prepare	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	5	case	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	24	24	CD	CD	_	10	nummod	_	_
8	healthy	healthy	JJ	JJ	_	10	amod	_	_
9	pregnant	pregnant	JJ	JJ	_	8	dep	_	_
10	women	woman	NNS	NNS	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	11	11	CD	CD	_	10	dep	_	_
13	first	first	JJ	JJ	_	12	dep	_	_
14	,	,	,	,	_	12	punct	_	_
15	10	10	CD	CD	_	12	conj	_	_
16	second	second	JJ	JJ	_	15	dep	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	three	three	CD	CD	_	12	conj	_	_
19	third	third	JJ	JJ	_	18	dep	_	_
20	trimester	trimester	NN	NN	_	12	dep	_	_
21	)	)	-RRB-	-RRB-	_	12	punct	_	_
22	,	,	,	,	_	10	punct	_	_
23	seven	seven	CD	CD	_	26	nummod	_	_
24	healthy	healthy	JJ	JJ	_	26	amod	_	_
25	non-pregnant	non-pregnant	JJ	JJ	_	24	dep	_	_
26	women	woman	NNS	NNS	_	10	conj	_	_
27	,	,	,	,	_	10	punct	_	_
28	nine	nine	CD	CD	_	29	nummod	_	_
29	women	woman	NNS	NNS	_	10	conj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	recurrent	recurrent	JJ	JJ	_	33	amod	_	_
32	spontaneous	spontaneous	JJ	JJ	_	31	dep	_	_
33	abortion	abortion	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	10	punct	_	_
35	and	and	CC	CC	_	10	cc	_	_
36	six	six	CD	CD	_	38	nummod	_	_
37	healthy	healthy	JJ	JJ	_	38	amod	_	_
38	men	man	NNS	NNS	_	10	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	a	a	DT	DT	_	9	det	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	breast	breast	NN	NN	_	9	compound	_	_
7	carcinoma	carcinoma	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	21	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ZR-75-1	zr-75-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	expresses	express	VBZ	VBZ	_	9	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	progesterone	progesterone	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	15	dobj	_	_
19	,	,	,	,	_	9	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	analysed	analyse	VBN	VBN	_	0	root	_	_
22	throughout	throughout	RB	RB	_	21	advmod	_	_
23	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ZR-75-1	zr-75-1	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	line	line	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	an	a	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	642	642	CD	CD	_	10	nummod	_	_
10	fmol/mg	fmol/mg	NN	NN	_	7	nmod	_	_
11	whereas	whereas	IN	IN	_	16	mark	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	pregnant	pregnant	JJ	JJ	_	15	amod	_	_
15	women	woman	NNS	NNS	_	12	nmod	_	_
16	showed	show	VBD	VBD	_	5	advcl	_	_
17	an	a	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	&lt;	&lt;	JJR	JJR	_	18	dep	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	=	=	JJ	JJ	_	19	conj	_	_
22	4	4	CD	CD	_	23	nummod	_	_
23	fmol/mg	fmol/mg	NN	NN	_	19	dep	_	_
24	.	.	.	.	_	5	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	non-pregnant	non-pregnant	JJ	JJ	_	4	amod	_	_
4	women	woman	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	women	woman	NNS	NNS	_	4	conj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	threatened	threaten	VBN	VBN	_	10	amod	_	_
9	pre-term	pre-term	JJ	JJ	_	10	amod	_	_
10	delivery	delivery	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	men	man	NNS	NNS	_	4	conj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	equivalent	equivalent	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	14	dobj	_	_
17	:	:	:	:	_	14	punct	_	_
18	3	3	CD	CD	_	14	dep	_	_
19	+/-	+/-	CC	CC	_	18	cc	_	_
20	1	1	CD	CD	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	3	3	CD	CD	_	18	conj	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	2	2	CD	CD	_	22	conj	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	5	5	CD	CD	_	18	conj	_	_
27	+/-	+/-	CC	CC	_	26	cc	_	_
28	4	4	CD	CD	_	26	conj	_	_
29	fmol/mg	fmol/mg	NN	NN	_	18	dep	_	_
30	respectively	respectively	RB	RB	_	18	advmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	is	be	VBZ	VBZ	_	3	ccomp	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	evidence	evidence	NN	NN	_	6	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	progesterone	progesterone	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	pregnancy	pregnancy	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	exclude	exclude	VBP	VBP	_	3	conj	_	_
20	any	any	DT	DT	_	22	det	_	_
21	prognostic	prognostic	JJ	JJ	_	22	amod	_	_
22	character	character	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	spontaneous	spontaneous	JJ	JJ	_	25	amod	_	_
25	abortion	abortion	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	22	nsubjpass	_	_
3	for	for	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	progesterone	progesterone	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	mechanism	mechanism	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	known	known	JJ	JJ	_	13	amod	_	_
13	effect	effect	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	progesterone	progesterone	NN	NN	_	13	nmod	_	_
16	on	on	IN	IN	_	19	case	_	_
17	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	excluded	exclude	VBN	VBN	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	Influence	influence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	age	age	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	production	production	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Fos	fos	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Jun	jun	NN	NN	_	8	conj	_	_
11	by	by	IN	IN	_	15	case	_	_
12	influenza	influenza	NN	NN	_	15	compound	_	_
13	virus-exposed	virus-exposed	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	age-related	age-related	JJ	JJ	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	responses	response	NNS	NNS	_	3	dobj	_	_
8	after	after	IN	IN	_	11	case	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	exposure	exposure	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	influenza	influenza	NN	NN	_	15	compound	_	_
14	A	a	NN	NN	_	15	compound	_	_
15	virus	virus	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	leukocytes	leukocyte	NNS	NNS	_	9	nsubjpass	_	_
3	from	from	IN	IN	_	4	case	_	_
4	young	young	JJ	JJ	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	elderly	elderly	JJ	JJ	_	4	conj	_	_
7	persons	person	NNS	NNS	_	4	dep	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	sham-exposed	sham-expose	VBN	VBN	_	0	root	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	exposed	expose	VBN	VBN	_	9	conj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	influenza	influenza	NN	NN	_	14	compound	_	_
14	virus	virus	NN	NN	_	11	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	1	1	CD	CD	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	24	24	CD	CD	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	72	72	CD	CD	_	16	conj	_	_
22	h	h	NN	NN	_	16	dep	_	_
23	.	.	.	.	_	9	punct	_	_

1	Immunofluorescent	immunofluorescent	JJ	JJ	_	2	amod	_	_
2	staining	staining	NN	NN	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	flow	flow	NN	NN	_	6	compound	_	_
5	cytometric	cytometric	JJ	JJ	_	6	amod	_	_
6	analysis	analysis	NN	NN	_	2	conj	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	then	then	RB	RB	_	9	advmod	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	detect	detect	VB	VB	_	9	xcomp	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	11	dobj	_	_
14	producing	produce	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
17	regulating	regulating	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	14	dobj	_	_
19	Fos	fos	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Jun	jun	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Fewer	fewer	JJR	JJR	_	3	amod	_	_
2	virus-exposed	virus-exposed	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	7	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	elderly	elderly	JJ	JJ	_	6	amod	_	_
6	donors	donor	NNS	NNS	_	3	nmod	_	_
7	stained	stain	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	Fos	fos	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Jun	jun	NN	NN	_	9	conj	_	_
12	at	at	IN	IN	_	15	case	_	_
13	each	each	DT	DT	_	15	det	_	_
14	data	datum	NNS	NNS	_	15	compound	_	_
15	point	point	NN	NN	_	7	nmod	_	_
16	compared	compare	VBD	VBD	_	18	dep	_	_
17	with	with	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	7	advcl	_	_
19	from	from	IN	IN	_	21	case	_	_
20	young	young	JJ	JJ	_	21	amod	_	_
21	donors	donor	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Flow	flow	NN	NN	_	3	compound	_	_
2	cytometric	cytometric	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	at	at	IN	IN	_	9	case	_	_
8	72	72	CD	CD	_	9	nummod	_	_
9	h	h	NN	NN	_	19	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	virus	virus	NN	NN	_	12	compound	_	_
12	exposure	exposure	NN	NN	_	9	nmod	_	_
13	fewer	fewer	JJR	JJR	_	19	nsubj	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	13	dep	_	_
16	from	from	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	elderly	elderly	JJ	JJ	_	13	nmod	_	_
19	produced	produce	VBD	VBD	_	5	ccomp	_	_
20	interferon-gamma	interferon-gamma	NN	NN	_	19	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IFN-gamma	ifn-gamma	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	19	punct	_	_
25	suggesting	suggest	VBG	VBG	_	19	dep	_	_
26	a	a	DT	DT	_	27	det	_	_
27	link	link	NN	NN	_	25	dobj	_	_
28	between	between	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	magnitude	magnitude	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	dep	_	_
33	Fos	fos	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Jun	jun	NN	NN	_	33	conj	_	_
36	and	and	CC	CC	_	33	cc	_	_
37	IFN-gamma	ifn-gamma	NN	NN	_	33	conj	_	_
38	responses	response	NNS	NNS	_	33	dep	_	_
39	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	failure	failure	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	virus-exposed	virus-exposed	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	produce	produce	VB	VB	_	3	acl	_	_
10	Fos	fos	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Jun	jun	NN	NN	_	10	conj	_	_
13	could	could	MD	MD	_	14	aux	_	_
14	contribute	contribute	VB	VB	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	increase	increase	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	illness	illness	NN	NN	_	17	nmod	_	_
20	due	due	JJ	JJ	_	23	case	_	_
21	to	to	TO	TO	_	23	case	_	_
22	influenza	influenza	NN	NN	_	23	compound	_	_
23	virus	virus	NN	NN	_	19	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	elderly	elderly	JJ	JJ	_	19	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	Platelet-activating	platelet-activating	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PAF	paf	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	positively	positively	RB	RB	_	7	advmod	_	_
7	auto-regulates	auto-regulate	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	PAF	paf	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	transcript	transcript	NN	NN	_	9	nmod	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	leukocyte-type	leukocyte-type	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	through	through	IN	IN	_	21	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	7	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	human	human	JJ	JJ	_	9	amod	_	_
3	platelet-activating	platelet-activating	JJ	JJ	_	9	amod	_	_
4	factor	factor	NN	NN	_	9	compound	_	_
5	receptor	receptor	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	PAFR	pafr	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	gene	gene	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	transcribed	transcribe	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	distinct	distinct	JJ	JJ	_	15	amod	_	_
15	promoters	promoter	NNS	NNS	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	promoter	promoter	NN	NN	_	15	dep	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	promoter	promoter	NN	NN	_	17	conj	_	_
21	2	2	CD	CD	_	20	nummod	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	generate	generate	VB	VB	_	11	xcomp	_	_
25	two	two	CD	CD	_	26	nummod	_	_
26	transcripts	transcript	NNS	NNS	_	24	dobj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	designated	designate	VBN	VBN	_	26	dep	_	_
29	as	as	IN	IN	_	31	case	_	_
30	PAFR	pafr	NN	NN	_	31	compound	_	_
31	transcript	transcript	NN	NN	_	28	nmod	_	_
32	1	1	CD	CD	_	31	nummod	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	PAFR	pafr	NN	NN	_	35	compound	_	_
35	transcript	transcript	NN	NN	_	31	conj	_	_
36	2	2	CD	CD	_	35	nummod	_	_
37	)	)	-RRB-	-RRB-	_	28	punct	_	_
38	,	,	,	,	_	11	punct	_	_
39	though	though	IN	IN	_	45	mark	_	_
40	their	they	PRP$	PRP$	_	43	nmod:poss	_	_
41	open	open	JJ	JJ	_	43	amod	_	_
42	reading	reading	NN	NN	_	43	compound	_	_
43	frames	frame	NNS	NNS	_	45	nsubj	_	_
44	are	be	VBP	VBP	_	45	cop	_	_
45	identical	identical	JJ	JJ	_	11	advcl	_	_
46	.	.	.	.	_	11	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	primer	primer	NN	NN	_	4	compound	_	_
3	extension	extension	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	11	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	discriminate	discriminate	VB	VB	_	4	acl	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	transcripts	transcript	NNS	NNS	_	6	dobj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	found	find	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	33	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	levels	level	NNS	NNS	_	33	nsubjpass	_	_
15	of	of	IN	IN	_	17	case	_	_
16	PAFR	pafr	NN	NN	_	17	compound	_	_
17	transcript	transcript	NN	NN	_	14	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	leukocyte-type	leukocyte-type	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	17	punct	_	_
23	but	but	CC	CC	_	24	cc	_	_
24	not	not	RB	RB	_	17	cc	_	_
25	PAFR	pafr	NN	NN	_	26	compound	_	_
26	transcript	transcript	NN	NN	_	17	conj	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	tissue-type	tissue-type	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	14	punct	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	upregulated	upregulate	VBN	VBN	_	11	ccomp	_	_
34	by	by	IN	IN	_	35	case	_	_
35	PAF	paf	NN	NN	_	33	nmod	_	_
36	as	as	RB	RB	_	35	cc	_	_
37	well	well	RB	RB	_	36	mwe	_	_
38	as	as	IN	IN	_	36	mwe	_	_
39	by	by	IN	IN	_	40	case	_	_
40	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	35	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	TPA	tpa	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	in	in	IN	IN	_	50	case	_	_
45	the	the	DT	DT	_	50	det	_	_
46	human	human	JJ	JJ	_	50	amod	_	_
47	stomach	stomach	NN	NN	_	50	compound	_	_
48	cancer	cancer	NN	NN	_	50	compound	_	_
49	cell	cell	NN	NN	_	50	compound	_	_
50	line	line	NN	NN	_	40	nmod	_	_
51	(	(	-LRB-	-LRB-	_	53	punct	_	_
52	JR-St	jr-st	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	50	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	which	which	WDT	WDT	_	56	nsubj	_	_
56	expresses	express	VBZ	VBZ	_	50	acl:relcl	_	_
57	both	both	CC	CC	_	60	cc:preconj	_	_
58	functional	functional	JJ	JJ	_	60	dep	_	_
59	PAFR	pafr	NN	NN	_	60	compound	_	_
60	transcript	transcript	NN	NN	_	56	dobj	_	_
61	1	1	CD	CD	_	60	nummod	_	_
62	and	and	CC	CC	_	60	cc	_	_
63	PAFR	pafr	NN	NN	_	64	compound	_	_
64	transcript	transcript	NN	NN	_	60	conj	_	_
65	2	2	CD	CD	_	64	nummod	_	_
66	endogenously	endogenously	RB	RB	_	56	advmod	_	_
67	.	.	.	.	_	11	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	2	nmod	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	transient	transient	JJ	JJ	_	11	amod	_	_
10	expression	expression	NN	NN	_	11	compound	_	_
11	assay	assay	NN	NN	_	2	nmod	_	_
12	using	use	VBG	VBG	_	11	acl	_	_
13	chloramphenicol	chloramphenicol	NN	NN	_	18	compound	_	_
14	acetyltransferase	acetyltransferase	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	CAT	cat	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	gene	gene	NN	NN	_	12	dobj	_	_
19	as	as	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	reporter	reporter	NN	NN	_	12	nmod	_	_
22	showed	show	VBD	VBD	_	0	root	_	_
23	that	that	IN	IN	_	28	mark	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	PAF	paf	NN	NN	_	28	nsubj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	TPA	tpa	NN	NN	_	25	conj	_	_
28	activated	activate	VBD	VBD	_	22	ccomp	_	_
29	the	the	DT	DT	_	30	det	_	_
30	promoter	promoter	NN	NN	_	28	dobj	_	_
31	1	1	CD	CD	_	30	nummod	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	30	cc	_	_
34	the	the	DT	DT	_	36	det	_	_
35	deleted	deleted	JJ	JJ	_	36	amod	_	_
36	promoter	promoter	NN	NN	_	30	conj	_	_
37	lacking	lack	VBG	VBG	_	36	acl	_	_
38	the	the	DT	DT	_	42	det	_	_
39	three	three	CD	CD	_	42	nummod	_	_
40	consensus	consensus	NN	NN	_	42	compound	_	_
41	binding	binding	NN	NN	_	42	compound	_	_
42	sites	site	NNS	NNS	_	37	dobj	_	_
43	for	for	IN	IN	_	45	case	_	_
44	NF-kappa	nf-kappa	NN	NN	_	45	compound	_	_
45	B	b	NN	NN	_	42	nmod	_	_
46	located	located	JJ	JJ	_	42	amod	_	_
47	from	from	IN	IN	_	49	case	_	_
48	-571	-571	CD	CD	_	49	nummod	_	_
49	bp	bp	NN	NN	_	46	nmod	_	_
50	to	to	TO	TO	_	52	case	_	_
51	-459	-459	CD	CD	_	52	nummod	_	_
52	bp	bp	NN	NN	_	46	nmod	_	_
53	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	positive	positive	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	PAFR	pafr	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	PAF	paf	NN	NN	_	9	nmod	_	_
16	through	through	IN	IN	_	18	case	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	possibly	possibly	RB	RB	_	24	advmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	phosphorylation	phosphorylation	NN	NN	_	24	compound	_	_
24	reaction	reaction	NN	NN	_	15	nmod	_	_
25	involving	involve	VBG	VBG	_	24	acl	_	_
26	protein	protein	NN	NN	_	28	compound	_	_
27	kinase	kinase	NN	NN	_	28	compound	_	_
28	C	c	NN	NN	_	25	dobj	_	_
29	by	by	IN	IN	_	30	case	_	_
30	PAF	paf	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	The	the	DT	DT	_	3	det	_	_
3	changes	change	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
9	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	asthmatic	asthmatic	JJ	JJ	_	12	amod	_	_
12	subjects	subject	NNS	NNS	_	9	nmod	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	GCR	gcr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	11	case	_	_
10	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	determined	determine	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	radioligand-binding	radioligand-binding	JJ	JJ	_	16	amod	_	_
16	assay	assay	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	extrinsic	extrinsic	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	intrinsic	intrinsic	JJ	JJ	_	18	conj	_	_
21	asthmatics	asthmatic	NNS	NNS	_	13	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Their	they	PRP$	PRP$	_	5	nmod:poss	_	_
2	corresponding	corresponding	JJ	JJ	_	5	amod	_	_
3	plasma	plasma	NN	NN	_	5	compound	_	_
4	cortisol	cortisol	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	assessed	assess	VBN	VBN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	average	average	JJ	JJ	_	7	amod	_	_
7	number	number	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GCR	gcr	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	asthmatics	asthmatic	NNS	NNS	_	9	nmod	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	lower	lower	JJR	JJR	_	3	ccomp	_	_
15	than	than	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	healthy	healthy	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	P	p	NN	NN	_	23	dep	_	_
22	&lt;	&lt;	JJR	JJR	_	23	advmod	_	_
23	0.01	0.01	CD	CD	_	14	parataxis	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	14	punct	_	_
26	and	and	CC	CC	_	14	cc	_	_
27	there	there	EX	EX	_	28	expl	_	_
28	was	be	VBD	VBD	_	14	conj	_	_
29	a	a	DT	DT	_	31	det	_	_
30	linear	linear	JJ	JJ	_	31	amod	_	_
31	correlation	correlation	NN	NN	_	28	nsubj	_	_
32	between	between	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	number	number	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	GCR	gcr	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	34	cc	_	_
38	the	the	DT	DT	_	39	det	_	_
39	course	course	NN	NN	_	34	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	asthma	asthma	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Besides	besides	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	also	also	RB	RB	_	4	advmod	_	_
6	a	a	DT	DT	_	8	det	_	_
7	linear	linear	JJ	JJ	_	8	amod	_	_
8	correlation	correlation	NN	NN	_	4	nsubj	_	_
9	between	between	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	GCR	gcr	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	age	age	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	initial	initial	JJ	JJ	_	20	amod	_	_
20	attack	attack	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	asthma	asthma	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	difference	difference	NN	NN	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	plasma	plasma	NN	NN	_	6	compound	_	_
5	cortisol	cortisol	NN	NN	_	6	compound	_	_
6	level	level	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	10	case	_	_
10	asthmatics	asthmatic	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	healthy	healthy	JJ	JJ	_	13	amod	_	_
13	subjects	subject	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	is	be	VBZ	VBZ	_	3	ccomp	_	_
7	no	no	DT	DT	_	11	neg	_	_
8	primary	primary	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	general	general	JJ	JJ	_	8	conj	_	_
11	impairment	impairment	NN	NN	_	6	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	metabolism	metabolism	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	asthmatics	asthmatic	NNS	NNS	_	6	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	but	but	CC	CC	_	6	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	number	number	NN	NN	_	28	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	GCR	gcr	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	asthmatics	asthmatic	NNS	NNS	_	23	nmod	_	_
27	is	be	VBZ	VBZ	_	28	cop	_	_
28	lower	lower	JJR	JJR	_	6	conj	_	_
29	than	than	IN	IN	_	30	case	_	_
30	that	that	DT	DT	_	28	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	healthy	healthy	JJ	JJ	_	33	amod	_	_
33	controls	control	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GCR	gcr	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	asthmatics	asthmatic	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	think	think	VBP	VBP	_	15	parataxis	_	_
13	,	,	,	,	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	related	related	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	heredity	heredity	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	repeated	repeat	VBN	VBN	_	20	amod	_	_
20	attacks	attack	NNS	NNS	_	17	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	asthma	asthma	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Interleukin-2	interleukin-2	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	4	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	stat3	stat3	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	early	early	RB	RB	_	4	advmod	_	_
3	biochemical	biochemical	JJ	JJ	_	4	amod	_	_
4	event	event	NN	NN	_	19	nsubj	_	_
5	associated	associate	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	through	through	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	interleukin-2	interleukin-2	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL-2R	il-2r	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	0	root	_	_
20	of	of	IN	IN	_	23	case	_	_
21	several	several	JJ	JJ	_	23	amod	_	_
22	intracellular	intracellular	JJ	JJ	_	23	amod	_	_
23	substrates	substrate	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	exact	exact	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	14	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	7	nmod	_	_
6	IL-2	il-2	NN	NN	_	7	nsubj	_	_
7	regulates	regulate	VBZ	VBZ	_	3	acl:relcl	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	presently	presently	RB	RB	_	14	advmod	_	_
14	unknown	unknown	JJ	JJ	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
7	through	through	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	IL-2R	il-2r	NN	NN	_	6	nmod	_	_
10	induced	induced	JJ	JJ	_	4	ccomp	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	subsequent	subsequent	JJ	JJ	_	16	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	translocation	translocation	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	stat3	stat3	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	23	det	_	_
21	newly	newly	RB	RB	_	22	advmod	_	_
22	identified	identify	VBN	VBN	_	23	amod	_	_
23	member	member	NN	NN	_	18	appos	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	signal	signal	NN	NN	_	27	compound	_	_
27	transducers	transducer	NNS	NNS	_	23	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	activators	activator	NNS	NNS	_	35	compound	_	_
30	of	of	IN	IN	_	35	amod	_	_
31	transcription	transcription	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	STAT	stat	NN	NN	_	35	compound	_	_
34	)	)	-RRB-	-RRB-	_	35	punct	_	_
35	family	family	NN	NN	_	27	conj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	proteins	protein	NNS	NNS	_	27	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	stat1	stat1	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	9	nsubj	_	_
6	were	be	VBD	VBD	_	9	cop	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	tyrosine	tyrosine	NN	NN	_	9	nmod:npmod	_	_
9	phosphorylated	phosphorylated	JJ	JJ	_	0	root	_	_
10	after	after	IN	IN	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	ligation	ligation	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	whereas	whereas	IN	IN	_	26	mark	_	_
15	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	17	amod	_	_
16	stat1	stat1	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	26	nsubjpass	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	91	91	CD	CD	_	17	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	84	84	CD	CD	_	19	conj	_	_
22	kDa	kda	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	19	dep	_	_
24	)	)	-RRB-	-RRB-	_	19	punct	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	translocated	translocate	VBN	VBN	_	9	advcl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	nucleus	nucleus	NN	NN	_	26	nmod	_	_
30	following	following	NN	NN	_	32	dep	_	_
31	interferon-gamma	interferon-gamma	NN	NN	_	32	compound	_	_
32	treatment	treatment	NN	NN	_	26	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	HeLa	hela	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	Apart	apart	RB	RB	_	10	dep	_	_
2	from	from	IN	IN	_	3	case	_	_
3	stat3	stat3	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	another	another	DT	DT	_	7	det	_	_
6	cytoplasmic	cytoplasmic	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	tyrosine	tyrosine	NN	NN	_	10	nmod:npmod	_	_
10	phosphorylated	phosphorylated	JJ	JJ	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	subsequently	subsequently	RB	RB	_	10	advmod	_	_
13	translocated	translocate	VBN	VBN	_	10	conj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nucleus	nucleus	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	response	response	NN	NN	_	13	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	7	det	_	_
5	apparent	apparent	JJ	JJ	_	7	amod	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mass	mass	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	84	84	CD	CD	_	10	nummod	_	_
10	kDa	kda	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	recognized	recognize	VBN	VBN	_	3	conj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	stat3	stat3	NN	NN	_	14	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	stat1	stat1	NN	NN	_	19	compound	_	_
19	mAb	mab	NN	NN	_	16	conj	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	antisera	antisera	NNS	NNS	_	16	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	IL-2	il-2	NN	NN	_	5	dep	_	_
3	induced	induced	JJ	JJ	_	5	dep	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	translocation	translocation	NN	NN	_	20	advcl	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	84	84	CD	CD	_	10	nummod	_	_
9	kDa	kda	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	stat3	stat3	NN	NN	_	13	nsubj	_	_
13	followed	follow	VBD	VBD	_	5	conj	_	_
14	identical	identical	JJ	JJ	_	15	amod	_	_
15	kinetics	kinetics	NNS	NNS	_	13	dobj	_	_
16	,	,	,	,	_	20	punct	_	_
17	p84	p84	NN	NN	_	20	nsubj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	a	a	DT	DT	_	20	det	_	_
20	candidate	candidate	NN	NN	_	0	root	_	_
21	for	for	IN	IN	_	28	case	_	_
22	a	a	DT	DT	_	28	det	_	_
23	new	new	JJ	JJ	_	28	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	yet	yet	RB	RB	_	23	advmod	_	_
26	undefined	undefined	JJ	JJ	_	23	dep	_	_
27	,	,	,	,	_	28	punct	_	_
28	member	member	NN	NN	_	20	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	STAT	stat	NN	NN	_	32	compound	_	_
32	family	family	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	20	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	report	report	VBP	VBP	_	1	parataxis	_	_
6	that	that	DT	DT	_	8	mark	_	_
7	IL-2	il-2	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	5	dep	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	translocation	translocation	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	stat3	stat3	NN	NN	_	10	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	an	a	DT	DT	_	23	det	_	_
19	as	as	IN	IN	_	21	dep	_	_
20	yet	yet	RB	RB	_	21	advmod	_	_
21	undefined	undefined	JJ	JJ	_	23	amod	_	_
22	84-kDa	84-kda	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	16	conj	_	_
24	in	in	IN	IN	_	29	case	_	_
25	antigen-specific	antigen-specific	JJ	JJ	_	29	amod	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TCL1	tcl1	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	malignancies	malignancy	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TCL1	tcl1	NN	NN	_	3	compound	_	_
3	locus	locus	NN	NN	_	9	nsubjpass	_	_
4	on	on	IN	IN	_	6	case	_	_
5	chromosome	chromosome	NN	NN	_	6	compound	_	_
6	14q32.1	14q32.1	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	frequently	frequently	RB	RB	_	9	advmod	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	chromosomal	chromosomal	JJ	JJ	_	12	amod	_	_
12	translocations	translocation	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	inversions	inversion	NNS	NNS	_	12	conj	_	_
15	with	with	IN	IN	_	16	case	_	_
16	one	one	CD	CD	_	9	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	T-cell	t-cell	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	loci	locus	NNS	NNS	_	16	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	T-cell	t-cell	NN	NN	_	21	nmod	_	_
25	leukemias	leukemia	NNS	NNS	_	24	dep	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	lymphomas	lymphoma	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	chromosome	chromosome	NN	NN	_	4	compound	_	_
3	14	14	CD	CD	_	4	nummod	_	_
4	region	region	NN	NN	_	8	nsubj	_	_
5	translocated	translocate	VBN	VBN	_	4	dep	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	rearranged	rearrange	VBN	VBN	_	5	conj	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	approximately	approximately	RB	RB	_	10	advmod	_	_
10	350	350	CD	CD	_	11	nummod	_	_
11	kb	kb	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	DNA	dna	NN	NN	_	11	nmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	chromosome	chromosome	NN	NN	_	17	compound	_	_
16	band	band	NN	NN	_	17	compound	_	_
17	14q32.1	14q32.1	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	gene	gene	NN	NN	_	6	dobj	_	_
9	coding	code	VBG	VBG	_	8	acl	_	_
10	for	for	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	1.3-kb	1.3-kb	JJ	JJ	_	13	amod	_	_
13	transcript	transcript	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	expressed	express	VBN	VBN	_	8	dep	_	_
16	only	only	RB	RB	_	15	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	restricted	restricted	JJ	JJ	_	19	amod	_	_
19	subsets	subset	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	cells	cell	NNS	NNS	_	19	nmod	_	_
22	within	within	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	lineage	lineage	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	expressed	express	VBN	VBN	_	15	conj	_	_
28	at	at	IN	IN	_	30	case	_	_
29	high	high	JJ	JJ	_	30	amod	_	_
30	levels	level	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	leukemic	leukemic	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	carrying	carry	VBG	VBG	_	33	acl	_	_
35	a	a	DT	DT	_	39	det	_	_
36	t(14;14)	t(14;14)	NN	NN	_	39	compound	_	_
37	(q11;q32)	(q11;q32)	NN	NN	_	39	compound	_	_
38	chromosome	chromosome	NN	NN	_	39	compound	_	_
39	translocation	translocation	NN	NN	_	34	dobj	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	a	a	DT	DT	_	44	det	_	_
42	inv(14)(q11;q32)	inv(14)(q11;q32)	NN	NN	_	44	compound	_	_
43	chromosome	chromosome	NN	NN	_	44	compound	_	_
44	inversion	inversion	NN	NN	_	39	conj	_	_
45	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cognate	cognate	JJ	JJ	_	4	amod	_	_
3	cDNA	cdna	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	5	nsubj	_	_
5	reveals	reveal	VBZ	VBZ	_	0	root	_	_
6	an	a	DT	DT	_	9	det	_	_
7	open	open	JJ	JJ	_	9	amod	_	_
8	reading	reading	NN	NN	_	9	compound	_	_
9	frame	frame	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	342	342	CD	CD	_	12	nummod	_	_
12	nt	nt	NN	NN	_	9	nmod	_	_
13	encoding	encode	VBG	VBG	_	9	acl	_	_
14	a	a	DT	DT	_	18	det	_	_
15	protein	protein	NN	NN	_	18	compound	_	_
16	of	of	IN	IN	_	18	amod	_	_
17	14	14	CD	CD	_	18	nummod	_	_
18	kDa	kda	NN	NN	_	13	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	TCL1	tcl1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	23	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	12	nsubj	_	_
7	,	,	,	,	_	12	punct	_	_
8	to	to	TO	TO	_	10	case	_	_
9	our	we	PRP$	PRP$	_	10	nmod:poss	_	_
10	knowledge	knowledge	NN	NN	_	12	nmod	_	_
11	,	,	,	,	_	12	punct	_	_
12	shows	show	VBZ	VBZ	_	4	acl:relcl	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	sequence	sequence	NN	NN	_	15	compound	_	_
15	homology	homology	NN	NN	_	12	dobj	_	_
16	with	with	IN	IN	_	19	case	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	4	punct	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	preferentially	preferentially	RB	RB	_	23	advmod	_	_
23	expressed	express	VBN	VBN	_	0	root	_	_
24	early	early	RB	RB	_	23	advmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	T-	t-	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	B-lymphocyte	b-lymphocyte	NN	NN	_	26	conj	_	_
29	differentiation	differentiation	NN	NN	_	26	dep	_	_
30	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	Sp1	sp1	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	induction	induction	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	murine	murine	JJ	JJ	_	13	amod	_	_
12	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cis-acting	cis-acting	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	21	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	GM-kappa	gm-kappa	NN	NN	_	6	compound	_	_
6	B/GC-box	b/gc-box	NN	NN	_	3	appos	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	positions	position	NNS	NNS	_	6	dep	_	_
9	-95	-95	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	-73	-73	CD	CD	_	8	conj	_	_
12	)	)	-RRB-	-RRB-	_	8	punct	_	_
13	,	,	,	,	_	3	punct	_	_
14	within	within	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	murine	murine	NN	NN	_	19	compound	_	_
17	GM-CSF	gm-csf	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	3	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	0	root	_	_
22	for	for	IN	IN	_	24	case	_	_
23	maximal	maximal	JJ	JJ	_	24	amod	_	_
24	induction	induction	NN	NN	_	21	nmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	24	nmod	_	_
27	with	with	IN	IN	_	29	case	_	_
28	phorbol-12-myristate	phorbol-12-myristate	NN	NN	_	29	compound	_	_
29	acetate	acetate	NN	NN	_	26	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PMA	pma	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	calcium	calcium	NN	NN	_	35	compound	_	_
35	ionophore	ionophore	NN	NN	_	29	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	A23187	a23187	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	in	in	IN	IN	_	41	case	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	29	nmod	_	_
42	.	.	.	.	_	21	punct	_	_

1	GM-kappa	gm-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	nsubj	_	_
3	defines	define	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	site	site	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	GC-box	gc-box	NN	NN	_	13	nsubj	_	_
13	defines	define	VBZ	VBZ	_	3	conj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	site	site	NN	NN	_	13	dobj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	three	three	CD	CD	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	A1	a1	NN	NN	_	18	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	A2	a2	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	20	punct	_	_
24	B	b	NN	NN	_	20	appos	_	_
25	)	)	-RRB-	-RRB-	_	20	punct	_	_
26	constitutive	constitutive	JJ	JJ	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	18	dep	_	_
28	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	three	three	CD	CD	_	6	nummod	_	_
6	copies	copy	NNS	NNS	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	GC-box	gc-box	NN	NN	_	6	nmod	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	functionally	functionally	RB	RB	_	12	advmod	_	_
12	compensate	compensate	VB	VB	_	2	ccomp	_	_
13	for	for	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	GM-kappa	gm-kappa	NN	NN	_	17	compound	_	_
16	B/GC-box	b/gc-box	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	suggesting	suggest	VBG	VBG	_	12	advcl	_	_
20	that	that	IN	IN	_	24	mark	_	_
21	the	the	DT	DT	_	22	det	_	_
22	GC-motif	gc-motif	NN	NN	_	24	nsubj	_	_
23	can	can	MD	MD	_	24	aux	_	_
24	function	function	VB	VB	_	19	ccomp	_	_
25	independently	independently	RB	RB	_	24	advmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	GM-kappa	gm-kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	motif	motif	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	major	major	JJ	JJ	_	5	amod	_	_
3	GC-box	gc-box	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	8	nsubjpass	_	_
6	A1	a1	NN	NN	_	5	dep	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	purified	purify	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	identified	identify	VBN	VBN	_	8	conj	_	_
11	as	as	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	Sp1	sp1	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	depletion	depletion	NN	NN	_	14	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Sp1	sp1	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	A1	a1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	from	from	IN	IN	_	12	case	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	extracts	extract	NNS	NNS	_	4	nmod	_	_
13	specifically	specifically	RB	RB	_	14	advmod	_	_
14	decreases	decrease	VBZ	VBZ	_	2	ccomp	_	_
15	in	in	FW	FW	_	18	amod	_	_
16	vitro	vitro	FW	FW	_	15	dep	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	dobj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	GM-CSF	gm-csf	NN	NN	_	21	compound	_	_
21	templates	template	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	GM-CSF	gm-csf	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	15	advcl	_	_
7	a	a	DT	DT	_	9	det	_	_
8	base	base	NN	NN	_	9	compound	_	_
9	difference	difference	NN	NN	_	6	dobj	_	_
10	within	within	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	GC-box	gc-box	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	speculate	speculate	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	this	this	DT	DT	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	explain	explain	VB	VB	_	15	ccomp	_	_
20	why	why	WRB	WRB	_	25	advmod	_	_
21	the	the	DT	DT	_	23	det	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	promoter	promoter	NN	NN	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	weak	weak	JJ	JJ	_	19	advcl	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	an	a	DT	DT	_	30	det	_	_
29	upstream	upstream	JJ	JJ	_	30	amod	_	_
30	enhancer	enhancer	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	required	require	VBN	VBN	_	19	conj	_	_
33	for	for	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	induction	induction	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	human	human	JJ	JJ	_	40	amod	_	_
39	GM-CSF	gm-csf	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	C-terminus	c-terminus	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	activator	activator	NN	NN	_	2	nmod	_	_
8	Oct-2	oct-2	NN	NN	_	7	dep	_	_
9	functions	function	VBZ	VBZ	_	0	root	_	_
10	as	as	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	activation	activation	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	yeast	yeast	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Oct-1	oct-1	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Oct-2	oct-2	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	7	cop	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activators	activator	NNS	NNS	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	bind	bind	VBP	VBP	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	same	same	JJ	JJ	_	14	amod	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	element	element	NN	NN	_	9	nmod	_	_
15	but	but	CC	CC	_	9	cc	_	_
16	activate	activate	VBP	VBP	_	9	conj	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	sets	set	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	expressed	express	VBD	VBD	_	0	root	_	_
3	these	these	DT	DT	_	4	det	_	_
4	factors	factor	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	S.	s.	FW	FW	_	7	compound	_	_
7	cerevisiae	cerevisiae	FW	FW	_	2	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	observed	observe	VBD	VBD	_	2	conj	_	_
10	greater	greater	JJR	JJR	_	12	dep	_	_
11	than	than	IN	IN	_	12	dep	_	_
12	5-fold	5-fold	JJ	JJ	_	13	amod	_	_
13	stimulation	stimulation	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	lacZ	lacz	NN	NN	_	18	compound	_	_
17	reporter	reporter	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	only	only	RB	RB	_	13	advmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	Oct-2	oct-2	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Transfer	transfer	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	Oct-2	oct-2	NN	NN	_	6	compound	_	_
5	C-terminal	c-terminal	JJ	JJ	_	6	amod	_	_
6	domain	domain	NN	NN	_	1	nmod	_	_
7	onto	onto	IN	IN	_	9	case	_	_
8	either	either	CC	CC	_	9	cc:preconj	_	_
9	Oct-1	oct-1	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Oct1.2	oct1.2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	a	a	DT	DT	_	17	det	_	_
15	nonactivating	nonactivating	JJ	JJ	_	17	amod	_	_
16	DNA-binding	dna-binding	JJ	JJ	_	17	amod	_	_
17	domain	domain	NN	NN	_	9	conj	_	_
18	from	from	IN	IN	_	19	case	_	_
19	GAL4	gal4	NN	NN	_	17	nmod	_	_
20	created	create	VBD	VBD	_	0	root	_	_
21	activators	activator	NNS	NNS	_	20	dobj	_	_
22	capable	capable	JJ	JJ	_	21	amod	_	_
23	of	of	IN	IN	_	29	case	_	_
24	greater	greater	JJR	JJR	_	26	dep	_	_
25	than	than	IN	IN	_	26	dep	_	_
26	15	15	CD	CD	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	10-fold	10-fold	JJ	JJ	_	26	conj	_	_
29	stimulation	stimulation	NN	NN	_	22	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	activity	activity	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	20	punct	_	_
33	respectively	respectively	RB	RB	_	20	advmod	_	_
34	.	.	.	.	_	20	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	C-terminus	c-terminus	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Oct-2	oct-2	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	sufficient	sufficient	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	confer	confer	VB	VB	_	8	xcomp	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	potential	potential	NN	NN	_	10	dobj	_	_
13	to	to	TO	TO	_	16	case	_	_
14	nonactive	nonactive	JJ	JJ	_	16	amod	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	fragments	fragment	NNS	NNS	_	10	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	yeast	yeast	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	AP1	ap1	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	12	nsubj	_	_
5	upstream	upstream	JJ	JJ	_	4	advmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	11	compound	_	_
10	intron	intron	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	5	nmod	_	_
12	binds	bind	VBZ	VBZ	_	0	root	_	_
13	inducible	inducible	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	12	dobj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	contributes	contribute	VBZ	VBZ	_	12	conj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	expression	expression	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Expression	expression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	kappa	kappa	NN	NN	_	8	compound	_	_
5	immunoglobulin	immunoglobulin	NN	NN	_	8	compound	_	_
6	light	light	JJ	JJ	_	8	amod	_	_
7	chain	chain	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	1	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	developmental-	developmental-	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	tissue-specific	tissue-specific	JJ	JJ	_	10	conj	_	_
13	regulation	regulation	NN	NN	_	9	dobj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	trans-acting	trans-acting	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	interact	interact	VBP	VBP	_	16	acl:relcl	_	_
19	with	with	IN	IN	_	23	case	_	_
20	two	two	CD	CD	_	23	nummod	_	_
21	distinct	distinct	JJ	JJ	_	23	amod	_	_
22	enhancer	enhancer	NN	NN	_	23	compound	_	_
23	elements	element	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	new	new	JJ	JJ	_	4	amod	_	_
3	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
4	interaction	interaction	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	upstream	upstream	RB	RB	_	7	advmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	intron	intron	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	within	within	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	matrix-associated	matrix-associated	JJ	JJ	_	17	amod	_	_
17	region	region	NN	NN	_	7	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	J-C	j-c	JJ	JJ	_	21	amod	_	_
21	intron	intron	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	greatly	greatly	RB	RB	_	6	advmod	_	_
6	inducible	inducible	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	pre-B	pre-b	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	bacterial	bacterial	JJ	JJ	_	12	amod	_	_
12	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	interleukin-1	interleukin-1	NN	NN	_	12	conj	_	_
15	but	but	CC	CC	_	6	cc	_	_
16	specific	specific	JJ	JJ	_	17	amod	_	_
17	complexes	complex	NNS	NNS	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	6	conj	_	_
20	at	at	IN	IN	_	22	case	_	_
21	all	all	DT	DT	_	22	det	_	_
22	stages	stage	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	development	development	NN	NN	_	22	nmod	_	_
27	tested	test	VBN	VBN	_	26	acl	_	_
28	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	footprinted	footprint	VBN	VBN	_	4	amod	_	_
3	binding	bind	VBG	VBG	_	4	amod	_	_
4	site	site	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	homologous	homologous	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	consensus	consensus	NN	NN	_	11	compound	_	_
10	AP1	ap1	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	components	component	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	complex	complex	NN	NN	_	3	nmod	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	competed	compete	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	AP1	ap1	NN	NN	_	14	compound	_	_
13	consensus	consensus	NN	NN	_	14	compound	_	_
14	motif	motif	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	shown	show	VBN	VBN	_	9	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	supershift	supershift	NN	NN	_	17	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	include	include	VB	VB	_	17	xcomp	_	_
22	c-Jun	c-jun	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	c-Fos	c-fos	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	9	punct	_	_
26	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
27	that	that	IN	IN	_	34	mark	_	_
28	this	this	DT	DT	_	30	det	_	_
29	binding	bind	VBG	VBG	_	30	amod	_	_
30	site	site	NN	NN	_	34	nsubj	_	_
31	is	be	VBZ	VBZ	_	34	cop	_	_
32	an	a	DT	DT	_	34	det	_	_
33	AP1	ap1	NN	NN	_	34	compound	_	_
34	motif	motif	NN	NN	_	26	ccomp	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	that	that	IN	IN	_	45	mark	_	_
37	the	the	DT	DT	_	38	dep	_	_
38	Jun	jun	NN	NN	_	45	nsubj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	Fos	fos	NN	NN	_	38	conj	_	_
41	families	family	NNS	NNS	_	38	dep	_	_
42	of	of	IN	IN	_	44	case	_	_
43	transcription	transcription	NN	NN	_	44	compound	_	_
44	factors	factor	NNS	NNS	_	38	nmod	_	_
45	play	play	VBP	VBP	_	34	conj	_	_
46	a	a	DT	DT	_	47	det	_	_
47	role	role	NN	NN	_	45	dobj	_	_
48	in	in	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	regulation	regulation	NN	NN	_	45	nmod	_	_
51	of	of	IN	IN	_	56	case	_	_
52	the	the	DT	DT	_	56	det	_	_
53	kappa	kappa	NN	NN	_	56	compound	_	_
54	light	light	JJ	JJ	_	56	amod	_	_
55	chain	chain	NN	NN	_	56	compound	_	_
56	gene	gene	NN	NN	_	50	nmod	_	_
57	.	.	.	.	_	9	punct	_	_

1	Mutation	mutation	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	AP1	ap1	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	context	context	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	intron	intron	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	decrease	decrease	VB	VB	_	14	xcomp	_	_
17	enhancer-mediated	enhancer-mediated	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	both	both	CC	CC	_	25	cc:preconj	_	_
24	pre-B	pre-b	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	16	nmod	_	_
26	induced	induce	VBN	VBN	_	25	acl	_	_
27	with	with	IN	IN	_	28	case	_	_
28	LPS	lps	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	constitutive	constitutive	JJ	JJ	_	31	amod	_	_
31	expression	expression	NN	NN	_	25	conj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	mature	mature	JJ	JJ	_	35	amod	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	region	region	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	chicken	chicken	NN	NN	_	9	compound	_	_
8	anemia	anemia	NN	NN	_	9	compound	_	_
9	virus	virus	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CAV	cav	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	containing	contain	VBG	VBG	_	9	acl	_	_
14	a	a	DT	DT	_	17	det	_	_
15	novel	novel	JJ	JJ	_	17	amod	_	_
16	enhancer-like	enhancer-like	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	single	single	JJ	JJ	_	4	amod	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	33	nsubj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cloned	clone	VBN	VBN	_	8	amod	_	_
8	genome	genome	NN	NN	_	4	nmod	_	_
9	-LSB-	-lsb-	-LRB-	-LRB-	_	10	punct	_	_
10	Noteborn	Noteborn	NNP	NNP	_	4	dep	_	_
11	et	et	FW	FW	_	10	compound	_	_
12	al.	al.	FW	FW	_	10	dep	_	_
13	,	,	,	,	_	10	punct	_	_
14	J.	J.	NNP	NNP	_	15	compound	_	_
15	Virol.	Virol.	NNP	NNP	_	10	appos	_	_
16	65	65	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	1991	1991	CD	CD	_	10	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	3131-3139	3131-3139	CD	CD	_	10	dep	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	10	punct	_	_
22	of	of	IN	IN	_	25	case	_	_
23	chicken	chicken	NN	NN	_	25	compound	_	_
24	anemia	anemia	NN	NN	_	25	compound	_	_
25	virus	virus	NN	NN	_	4	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CAV	cav	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	31	case	_	_
30	chicken	chicken	NN	NN	_	31	compound	_	_
31	T-cells	t-cell	NNS	NNS	_	25	nmod	_	_
32	was	be	VBD	VBD	_	33	aux	_	_
33	analysed	analysed	JJ	JJ	_	0	root	_	_
34	via	via	IN	IN	_	36	case	_	_
35	CAT	cat	NN	NN	_	36	compound	_	_
36	assays	assay	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	33	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	unique	unique	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	22	nsubjpass	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	four	four	CD	CD	_	8	dep	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	five	five	CD	CD	_	5	conj	_	_
8	near-perfect	near-perfect	JJ	JJ	_	10	dep	_	_
9	direct	direct	JJ	JJ	_	10	amod	_	_
10	repeats	repeat	NNS	NNS	_	4	dobj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	DR	dr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	of	of	IN	IN	_	16	case	_	_
15	21	21	CD	CD	_	16	nummod	_	_
16	bp	bp	NN	NN	_	10	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	one	one	CD	CD	_	20	nummod	_	_
19	12-bp	12-bp	JJ	JJ	_	20	amod	_	_
20	insert	insert	NN	NN	_	4	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	proven	prove	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	28	mark	_	_
24	be	be	VB	VB	_	28	cop	_	_
25	the	the	DT	DT	_	28	det	_	_
26	main	main	JJ	JJ	_	28	amod	_	_
27	transcription-activation	transcription-activation	JJ	JJ	_	28	amod	_	_
28	element	element	NN	NN	_	22	xcomp	_	_
29	,	,	,	,	_	28	punct	_	_
30	with	with	IN	IN	_	32	case	_	_
31	enhancer-like	enhancer-like	JJ	JJ	_	32	amod	_	_
32	characteristics	characteristic	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	PCR	pcr	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	CAV	cav	NN	NN	_	6	compound	_	_
6	isolates	isolate	NNS	NNS	_	12	nsubj	_	_
7	from	from	IN	IN	_	10	case	_	_
8	across	across	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	world	world	NN	NN	_	6	nmod	_	_
11	all	all	DT	DT	_	12	advmod	_	_
12	contained	contain	VBD	VBD	_	3	ccomp	_	_
13	this	this	DT	DT	_	15	det	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
2	mobility-shift	mobility-shift	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EMSA	emsa	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	21	mark	_	_
9	individual	individual	JJ	JJ	_	11	amod	_	_
10	DR	dr	NN	NN	_	11	compound	_	_
11	units	unit	NNS	NNS	_	21	nsubj	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	RB	RB	_	11	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	the	the	DT	DT	_	18	det	_	_
17	12-bp	12-bp	JJ	JJ	_	18	amod	_	_
18	insert	insert	NN	NN	_	11	conj	_	_
19	,	,	,	,	_	11	punct	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	bind	bind	VB	VB	_	7	ccomp	_	_
22	to	to	TO	TO	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	chicken	chicken	NN	NN	_	27	compound	_	_
27	T-cells	t-cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Competition	competition	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DR	dr	NN	NN	_	7	compound	_	_
7	units	unit	NNS	NNS	_	8	nsubj	_	_
8	bound	bind	VBD	VBD	_	3	ccomp	_	_
9	to	to	TO	TO	_	10	case	_	_
10	factors	factor	NNS	NNS	_	8	nmod	_	_
11	other	other	JJ	JJ	_	10	amod	_	_
12	than	than	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	12-bp	12-bp	JJ	JJ	_	15	amod	_	_
15	insert	insert	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	synthetic	synthetic	JJ	JJ	_	3	amod	_	_
3	oligodeoxyribonucleotide	oligodeoxyribonucleotide	NN	NN	_	11	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	an	a	DT	DT	_	6	det	_	_
6	SP1-box	sp1-box	NN	NN	_	4	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	5'-GGGCGG	5'-gggcgg	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	could	could	MD	MD	_	11	aux	_	_
11	compete	compete	VB	VB	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	factors	factor	NNS	NNS	_	11	nmod	_	_
14	binding	bind	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	12-bp	12-bp	JJ	JJ	_	18	amod	_	_
18	insert	insert	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Purified	purify	VBN	VBN	_	3	amod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	SP1	sp1	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	have	have	VB	VB	_	5	xcomp	_	_
8	very	very	RB	RB	_	9	advmod	_	_
9	strong	strong	JJ	JJ	_	10	amod	_	_
10	affinity	affinity	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	12-bp	12-bp	JJ	JJ	_	14	amod	_	_
14	insert	insert	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	thymocytes	thymocyte	NNS	NNS	_	1	nmod	_	_
5	after	after	IN	IN	_	6	case	_	_
6	infection	infection	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	EBV	ebv	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	discovery	discovery	NN	NN	_	39	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	EBV	ebv	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	certain	certain	JJ	JJ	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	malignancies	malignancy	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	2	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	EBV	ebv	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	CR2/CD21	cr2/cd21	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	12	punct	_	_
20	on	on	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	population	population	NN	NN	_	12	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	immature	immature	JJ	JJ	_	25	amod	_	_
25	thymocytes	thymocyte	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	lymphoblastoid	lymphoblastoid	JJ	JJ	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	25	conj	_	_
31	,	,	,	,	_	25	punct	_	_
32	and	and	CC	CC	_	25	cc	_	_
33	childhood	childhood	NN	NN	_	38	compound	_	_
34	acute	acute	JJ	JJ	_	38	amod	_	_
35	T	t	NN	NN	_	38	compound	_	_
36	lymphoblastic	lymphoblastic	JJ	JJ	_	38	amod	_	_
37	leukemia	leukemia	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	25	conj	_	_
39	suggested	suggest	VBD	VBD	_	0	root	_	_
40	that	that	IN	IN	_	49	mark	_	_
41	EBV-receptor	ebv-receptor	NN	NN	_	42	compound	_	_
42	interactions	interaction	NNS	NNS	_	49	nsubj	_	_
43	on	on	IN	IN	_	45	case	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	may	may	MD	MD	_	49	aux	_	_
47	be	be	VB	VB	_	49	cop	_	_
48	of	of	IN	IN	_	49	case	_	_
49	importance	importance	NN	NN	_	39	ccomp	_	_
50	.	.	.	.	_	39	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	,	,	,	,	_	17	punct	_	_
6	within	within	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	thymus	thymus	NN	NN	_	17	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	population	population	NN	NN	_	17	nsubj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	large	large	JJ	JJ	_	16	amod	_	_
14	,	,	,	,	_	16	punct	_	_
15	immature	immature	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	expresses	express	VBZ	VBZ	_	3	ccomp	_	_
18	CD21	cd21	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	EBV	ebv	NN	NN	_	2	nsubj	_	_
2	altered	alter	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	activation	activation	NN	NN	_	5	compound	_	_
5	responses	response	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	immature	immature	JJ	JJ	_	8	amod	_	_
8	thymocytes	thymocyte	NNS	NNS	_	5	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	2	advmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Triggering	trigger	VBG	VBG	_	5	csubj	_	_
2	through	through	IN	IN	_	3	case	_	_
3	CD2	cd2	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	mitogenic	mitogenic	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	mature	mature	JJ	JJ	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	7	cc	_	_
11	immature	immature	JJ	JJ	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	during	during	IN	IN	_	4	case	_	_
4	infection	infection	NN	NN	_	11	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	EBV	ebv	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	ligation	ligation	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CD2	cd2	NN	NN	_	8	nmod	_	_
11	caused	cause	VBD	VBD	_	0	root	_	_
12	thymocytes	thymocyte	NNS	NNS	_	11	dobj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	proliferate	proliferate	VB	VB	_	11	xcomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	absence	absence	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	exogenous	exogenous	JJ	JJ	_	20	amod	_	_
20	cytokines	cytokine	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	a	a	DT	DT	_	5	det	_	_
5	result	result	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	EBV	ebv	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	CD21	cd21	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	5	punct	_	_
17	but	but	CC	CC	_	5	cc	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	caused	cause	VBN	VBN	_	5	conj	_	_
20	by	by	IN	IN	_	21	case	_	_
21	infection	infection	NN	NN	_	19	nmod	_	_
22	rather	rather	RB	RB	_	21	cc	_	_
23	than	than	IN	IN	_	22	mwe	_	_
24	surface	surface	NN	NN	_	25	compound	_	_
25	signaling	signaling	NN	NN	_	21	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	because	because	IN	IN	_	37	mark	_	_
28	neither	neither	CC	CC	_	30	cc:preconj	_	_
29	specific	specific	JJ	JJ	_	30	amod	_	_
30	mAb	mab	NN	NN	_	37	nsubj	_	_
31	nor	nor	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	34	det	_	_
33	P3HR-1	p3hr-1	NN	NN	_	34	compound	_	_
34	strain	strain	NN	NN	_	30	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	virus	virus	NN	NN	_	34	nmod	_	_
37	mimicked	mimic	VBD	VBD	_	19	advcl	_	_
38	the	the	DT	DT	_	39	det	_	_
39	effect	effect	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	B95-8	b95-8	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	5	punct	_	_

1	Immature	immature	JJ	JJ	_	2	amod	_	_
2	thymocytes	thymocyte	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	infected	infect	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	EBV	ebv	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	determined	determine	VBN	VBN	_	4	advcl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	internalization	internalization	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	viral	viral	JJ	JJ	_	16	amod	_	_
16	genome	genome	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	12	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	Consistent	consistent	JJ	JJ	_	11	dep	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	B95-8	b95-8	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	EBNA-2	ebna-2	NN	NN	_	9	compound	_	_
9	transcripts	transcript	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	within	within	IN	IN	_	15	case	_	_
13	infected	infected	JJ	JJ	_	15	amod	_	_
14	thymocyte	thymocyte	NN	NN	_	15	compound	_	_
15	populations	population	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	components	component	NNS	NNS	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	viral	viral	JJ	JJ	_	9	amod	_	_
8	replicative	replicative	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	4	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	during	during	IN	IN	_	13	case	_	_
13	infection	infection	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	components	component	NNS	NNS	_	3	nsubj	_	_
3	included	include	VBD	VBD	_	0	root	_	_
4	transcription	transcription	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	BZLF-1	bzlf-1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	an	a	DT	DT	_	10	det	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	6	appos	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	characterizes	characterize	VBZ	VBZ	_	10	acl:relcl	_	_
13	EBV-infected	ebv-infected	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	dobj	_	_
16	after	after	IN	IN	_	17	case	_	_
17	disruption	disruption	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	latency	latency	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	transcript	transcript	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	encoding	encode	VBG	VBG	_	5	advcl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	recently	recently	RB	RB	_	10	advmod	_	_
10	characterized	characterize	VBD	VBD	_	11	amod	_	_
11	RAZ	raz	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	16	nsubjpass	_	_
14	also	also	RB	RB	_	16	advmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	11	acl:relcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	replicative	replicative	JJ	JJ	_	19	amod	_	_
19	infection	infection	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	consequences	consequence	NNS	NNS	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	EBV	ebv	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	at	at	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	stage	stage	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	12	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	lead	lead	VB	VB	_	0	root	_	_
17	to	to	TO	TO	_	18	case	_	_
18	failure	failure	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	normal	normal	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cell	cell	NN	NN	_	18	nmod	_	_
23	repertoire	repertoire	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	22	dep	_	_
25	,	,	,	,	_	22	punct	_	_
26	autoimmunity	autoimmunity	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	or	or	CC	CC	_	22	cc	_	_
29	malignancy	malignancy	NN	NN	_	22	conj	_	_
30	.	.	.	.	_	16	punct	_	_

1	Alternate	alternate	JJ	JJ	_	3	amod	_	_
2	immune	immune	JJ	JJ	_	3	amod	_	_
3	system	system	NN	NN	_	0	root	_	_
4	targets	target	VBZ	VBZ	_	3	dep	_	_
5	for	for	IN	IN	_	6	case	_	_
6	TCDD	tcdd	NN	NN	_	3	nmod	_	_
7	:	:	:	:	_	3	punct	_	_
8	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
9	stem	stem	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	extrathymic	extrathymic	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	development	development	NN	NN	_	10	conj	_	_
15	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	here	here	RB	RB	_	3	advmod	_	_
3	summarize	summarize	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	thymic	thymic	JJ	JJ	_	7	amod	_	_
7	atrophy	atrophy	NN	NN	_	16	nsubjpass	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TCDD	tcdd	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	mediated	mediate	VBN	VBN	_	4	ccomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	at	at	IN	IN	_	21	advmod	_	_
19	least	least	JJS	JJS	_	18	mwe	_	_
20	in	in	IN	IN	_	21	case	_	_
21	part	part	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	by	by	IN	IN	_	24	case	_	_
24	damage	damage	NN	NN	_	16	nmod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	extrathymic	extrathymic	JJ	JJ	_	28	amod	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	precursors	precursor	NNS	NNS	_	24	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	bone	bone	NN	NN	_	31	compound	_	_
31	marrow	marrow	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	fetal	fetal	JJ	JJ	_	34	amod	_	_
34	liver	liver	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	atrophy	atrophy	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	involve	involve	VB	VB	_	0	root	_	_
7	apoptotic	apoptotic	JJ	JJ	_	8	amod	_	_
8	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	thymocytes	thymocyte	NNS	NNS	_	8	nmod	_	_
11	affected	affect	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	bcl-2	bcl-2	NN	NN	_	15	compound	_	_
15	proto-oncogene	proto-oncogene	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	TCDD	tcdd	NN	NN	_	2	nsubj	_	_
2	mediates	mediate	VBZ	VBZ	_	0	root	_	_
3	atrophy	atrophy	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	2	dobj	_	_
5	through	through	IN	IN	_	8	case	_	_
6	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	receptor	receptor	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	AhR	ahr	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	through	through	IN	IN	_	16	case	_	_
16	effects	effect	NNS	NNS	_	8	conj	_	_
17	on	on	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	estrogen	estrogen	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	TCDD	tcdd	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	estradiol	estradiol	NN	NN	_	2	conj	_	_
5	induce	induce	VBP	VBP	_	0	root	_	_
6	extrathymic	extrathymic	JJ	JJ	_	8	amod	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	liver	liver	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	extrathymic	extrathymic	JJ	JJ	_	4	amod	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	populations	population	NNS	NNS	_	5	nsubj	_	_
5	include	include	VBP	VBP	_	0	root	_	_
6	cells	cell	NNS	NNS	_	5	dobj	_	_
7	expressing	express	VBG	VBG	_	6	acl	_	_
8	elevated	elevated	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	V	v	NN	NN	_	14	compound	_	_
12	beta	beta	NN	NN	_	14	compound	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	nmod	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	are	be	VBP	VBP	_	18	auxpass	_	_
17	normally	normally	RB	RB	_	18	advmod	_	_
18	deleted	delete	VBN	VBN	_	14	acl:relcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	thymic	thymic	JJ	JJ	_	21	amod	_	_
21	development	development	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	B-cell	b-cell	NN	NN	_	0	root	_	_
2	proliferation	proliferation	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	induction	induction	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	early	early	JJ	JJ	_	8	amod	_	_
7	G1-regulating	g1-regulating	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	1	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	12	amod	_	_
11	virus	virus	NN	NN	_	12	compound	_	_
12	mutants	mutant	NNS	NNS	_	1	nmod	_	_
13	conditional	conditional	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	EBNA2	ebna2	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Infection	infection	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	primary	primary	JJ	JJ	_	4	amod	_	_
4	B-lymphocytes	b-lymphocyte	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EBV	ebv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	14	case	_	_
13	growth	growth	NN	NN	_	14	compound	_	_
14	transformation	transformation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	B-cells	b-cell	NNS	NNS	_	14	nmod	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	11	advmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	EBV	ebv	NN	NN	_	3	compound	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	antigen	antigen	NN	NN	_	24	nsubj	_	_
4	2	2	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EBNA2	ebna2	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	3	punct	_	_
9	one	one	CD	CD	_	3	appos	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	first	first	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	9	nmod	_	_
14	expressed	express	VBN	VBN	_	13	acl	_	_
15	after	after	IN	IN	_	17	case	_	_
16	EBV	ebv	NN	NN	_	17	compound	_	_
17	infection	infection	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	B-cells	b-cell	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	3	punct	_	_
21	is	be	VBZ	VBZ	_	24	cop	_	_
22	a	a	DT	DT	_	24	det	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activator	activator	NN	NN	_	0	root	_	_
25	of	of	IN	IN	_	29	case	_	_
26	viral	viral	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	cellular	cellular	JJ	JJ	_	26	conj	_	_
29	genes	gene	NNS	NNS	_	24	nmod	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	essential	essential	JJ	JJ	_	24	conj	_	_
33	for	for	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	transforming	transform	VBG	VBG	_	36	amod	_	_
36	potential	potential	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	virus	virus	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	generated	generate	VBD	VBD	_	0	root	_	_
3	conditional	conditional	JJ	JJ	_	5	amod	_	_
4	EBV	ebv	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	2	dobj	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	expressing	express	VBG	VBG	_	2	advcl	_	_
8	EBNA2	ebna2	NN	NN	_	7	dobj	_	_
9	as	as	IN	IN	_	12	case	_	_
10	chimeric	chimeric	JJ	JJ	_	12	amod	_	_
11	fusion	fusion	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	7	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	hormone	hormone	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	estrogen	estrogen	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	17	nmod	_	_
22	on	on	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	genetic	genetic	JJ	JJ	_	25	amod	_	_
25	background	background	NN	NN	_	7	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	virus	virus	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Growth	growth	NN	NN	_	2	compound	_	_
2	transformation	transformation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	primary	primary	JJ	JJ	_	6	amod	_	_
5	normal	normal	JJ	JJ	_	6	amod	_	_
6	B-cells	b-cell	NNS	NNS	_	2	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	mutant	mutant	JJ	JJ	_	9	amod	_	_
9	virus	virus	NN	NN	_	2	nmod	_	_
10	resulted	result	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	estrogen-dependent	estrogen-dependent	JJ	JJ	_	15	amod	_	_
13	lymphoblastoid	lymphoblastoid	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	10	nmod	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	chimeric	chimeric	JJ	JJ	_	20	amod	_	_
19	EBNA2	ebna2	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	estrogen	estrogen	NN	NN	_	3	nmod	_	_
6	about	about	RB	RB	_	7	advmod	_	_
7	half	half	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	enter	enter	VBP	VBP	_	0	root	_	_
12	a	a	DT	DT	_	15	det	_	_
13	quiescent	quiescent	JJ	JJ	_	15	amod	_	_
14	non-proliferative	non-proliferative	JJ	JJ	_	13	dep	_	_
15	state	state	NN	NN	_	11	dobj	_	_
16	whereas	whereas	IN	IN	_	19	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	others	other	NNS	NNS	_	19	nsubj	_	_
19	die	die	VBP	VBP	_	11	advcl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	EBNA2	ebna2	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	only	only	RB	RB	_	8	cc:preconj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	initiation	initiation	NN	NN	_	4	nmod	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	also	also	RB	RB	_	12	advmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	maintenance	maintenance	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	transformation	transformation	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Growth	growth	NN	NN	_	2	compound	_	_
2	arrest	arrest	NN	NN	_	3	nsubj	_	_
3	occurred	occur	VBD	VBD	_	0	root	_	_
4	at	at	IN	IN	_	5	case	_	_
5	G1	g1	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	G2	g2	NN	NN	_	5	conj	_	_
8	stages	stage	NNS	NNS	_	5	dep	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	cycle	cycle	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	indicating	indicate	VBG	VBG	_	3	xcomp	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	EBNA2	ebna2	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	14	ccomp	_	_
20	at	at	IN	IN	_	23	case	_	_
21	different	different	JJ	JJ	_	23	amod	_	_
22	restriction	restriction	NN	NN	_	23	compound	_	_
23	points	point	NNS	NNS	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	cycle	cycle	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Growth	growth	NN	NN	_	2	compound	_	_
2	arrest	arrest	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	reversible	reversible	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	G1/G0	g1/g0	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	indicated	indicate	VBN	VBN	_	4	advcl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	dep	_	_
12	sequential	sequential	JJ	JJ	_	13	amod	_	_
13	accumulation	accumulation	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	modification	modification	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	cell	cell	NN	NN	_	20	compound	_	_
18	cycle	cycle	NN	NN	_	20	compound	_	_
19	regulating	regulating	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	EBV	ebv	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	8	det	_	_
4	same	same	JJ	JJ	_	8	amod	_	_
5	cell	cell	NN	NN	_	8	compound	_	_
6	cycle	cycle	NN	NN	_	8	compound	_	_
7	regulating	regulating	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	2	dobj	_	_
9	as	as	IN	IN	_	11	case	_	_
10	polyclonal	polyclonal	JJ	JJ	_	11	amod	_	_
11	stimuli	stimulus	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	primary	primary	JJ	JJ	_	14	amod	_	_
14	B-cells	b-cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	EBV	ebv	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	aux	_	_
7	using	use	VBG	VBG	_	3	ccomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	common	common	JJ	JJ	_	10	amod	_	_
10	pathway	pathway	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	B-cell	b-cell	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	bypassing	bypass	VBG	VBG	_	7	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	requirement	requirement	NN	NN	_	14	dobj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	antigen	antigen	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	signals	signal	NNS	NNS	_	18	conj	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	growth	growth	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	18	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ICAM-1	icam-1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	LFA-3	lfa-3	NN	NN	_	3	conj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	Tax1	tax1	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	T-cell	t-cell	NN	NN	_	13	compound	_	_
11	leukemia	leukemia	NN	NN	_	13	compound	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	type	type	NN	NN	_	7	nmod	_	_
14	1	1	CD	CD	_	13	nummod	_	_
15	and	and	CC	CC	_	1	cc	_	_
16	mechanism	mechanism	NN	NN	_	1	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	down-regulation	down-regulation	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	ICAM-1	icam-1	NN	NN	_	18	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	LFA-1	lfa-1	NN	NN	_	20	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	adult-T-cell-leukemia	adult-t-cell-leukemia	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	undertaken	undertake	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HTLV-I	htlv-i	NN	NN	_	12	compound	_	_
12	TaxI	taxi	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	up-regulation	up-regulation	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	ICAM-I	icam-i	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	LFA-3	lfa-3	NN	NN	_	17	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	15	nmod	_	_
24	transformed	transform	VBN	VBN	_	23	acl	_	_
25	with	with	IN	IN	_	26	case	_	_
26	HTLV-I	htlv-i	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	9	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	mechanism	mechanism	NN	NN	_	9	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	down-regulation	down-regulation	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	ICAM-I	icam-i	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	LFA-I	lfa-i	NN	NN	_	33	conj	_	_
36	in	in	IN	IN	_	39	case	_	_
37	ATL-derived	atl-derived	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	lines	line	NNS	NNS	_	31	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	Induction	induction	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TaxI	taxi	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	T-cell	t-cell	NN	NN	_	9	compound	_	_
8	line	line	NN	NN	_	9	compound	_	_
9	Jurkat	jurkat	NN	NN	_	1	nmod	_	_
10	carrying	carry	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	TaxI	taxi	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	10	dobj	_	_
14	under	under	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	metallothionein	metallothionein	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	10	nmod	_	_
18	led	lead	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	20	case	_	_
20	increases	increase	NNS	NNS	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	mRNA	mrna	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	surface	surface	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	20	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	ICAM-I	icam-i	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	response	response	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	LFA-3	lfa-3	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	TaxI	taxi	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	16	cop	_	_
9	,	,	,	,	_	16	punct	_	_
10	on	on	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	hand	hand	NN	NN	_	16	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	relatively	relatively	RB	RB	_	16	advmod	_	_
16	slow	slow	JJ	JJ	_	0	root	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	weak	weak	JJ	JJ	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	might	might	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	indirect	indirect	JJ	JJ	_	16	conj	_	_
24	.	.	.	.	_	16	punct	_	_

1	Transactivation	transactivation	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	ICAM-I	icam-i	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	TaxI	taxi	NN	NN	_	1	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	co-transfection	co-transfection	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	CAT	cat	NN	NN	_	17	compound	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	construct	construct	NN	NN	_	12	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	ICAM-I	icam-i	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	12	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	24	det	_	_
24	plasmid	plasmid	NN	NN	_	21	conj	_	_
25	expressing	express	VBG	VBG	_	21	acl	_	_
26	TaxI	taxi	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	down-regulation	down-regulation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	ICAM-I	icam-i	NN	NN	_	4	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	LFA-I	lfa-i	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	4	4	CD	CD	_	13	nummod	_	_
11	ATL	atl	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	4	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	next	next	RB	RB	_	16	advmod	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	ICAM-I	icam-i	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	quite	quite	RB	RB	_	5	advmod	_	_
5	low	low	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	MT-I	mt-i	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	genomic	genomic	JJ	JJ	_	12	amod	_	_
12	changes	change	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	5	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CAT	cat	NN	NN	_	3	compound	_	_
3	reporter	reporter	NN	NN	_	9	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	ICAM-I	icam-i	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	inactive	inactive	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	MT-I	mt-i	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	combined	combined	JJ	JJ	_	4	amod	_	_
4	treatment	treatment	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	MT-I	mt-i	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	5-azacytidine	5-azacytidine	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	8	conj	_	_
11	induced	induce	VBD	VBD	_	0	root	_	_
12	re-expression	re-expression	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	ICAM-I	icam-i	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Collectively	collectively	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	(	(	-LRB-	-LRB-	_	9	punct	_	_
4	a	a	DT	DT	_	9	det	_	_
5	)	)	-RRB-	-RRB-	_	9	punct	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	19	nsubjpass	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	necessary	necessary	JJ	JJ	_	9	amod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	expression	expression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	ICAM-I	icam-i	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	13	nmod	_	_
17	may	may	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	repressed	repress	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	21	case	_	_
21	MT-I	mt-i	NN	NN	_	19	nmod	_	_
22	through	through	IN	IN	_	24	case	_	_
23	DNA	dna	NN	NN	_	24	compound	_	_
24	methylation	methylation	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	Three	three	CD	CD	_	5	nummod	_	_
2	other	other	JJ	JJ	_	5	amod	_	_
3	ATL	atl	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	14	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TL-OmI	tl-omi	NN	NN	_	5	dep	_	_
8	,	,	,	,	_	7	punct	_	_
9	H582	h582	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	HuT102	hut102	NN	NN	_	7	appos	_	_
12	)	)	-RRB-	-RRB-	_	7	punct	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	have	have	VB	VB	_	14	xcomp	_	_
17	little	little	JJ	JJ	_	18	amod	_	_
18	mRNA	mrna	NN	NN	_	16	dobj	_	_
19	for	for	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	LFA-I	lfa-i	NN	NN	_	23	compound	_	_
22	beta	beta	NN	NN	_	23	compound	_	_
23	chain	chain	NN	NN	_	16	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CD18	cd18	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	14	punct	_	_

1	H582	h582	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	HuT102	hut102	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	6	cop	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	negative	negative	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	LFA-I	lfa-i	NN	NN	_	15	compound	_	_
10	alpha	alpha	NN	NN	_	15	compound	_	_
11	chain	chain	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	CDIIa	cdiia	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	mRNA	mrna	NN	NN	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	genomic	genomic	JJ	JJ	_	3	amod	_	_
3	changes	change	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	a	a	DT	DT	_	11	det	_	_
9	CAT	cat	NN	NN	_	11	compound	_	_
10	reporter	reporter	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	17	nsubj	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CD18	cd18	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	inactive	inactive	JJ	JJ	_	5	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	3	3	CD	CD	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	them	they	PRP	PRP	_	20	nmod	_	_
23	,	,	,	,	_	5	punct	_	_
24	again	again	RB	RB	_	25	advmod	_	_
25	suggesting	suggest	VBG	VBG	_	5	conj	_	_
26	lack	lack	NN	NN	_	25	dobj	_	_
27	of	of	IN	IN	_	34	case	_	_
28	(	(	-LRB-	-LRB-	_	34	punct	_	_
29	a	a	DT	DT	_	34	det	_	_
30	)	)	-RRB-	-RRB-	_	34	punct	_	_
31	transcriptional	transcriptional	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	34	compound	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	s	s	NNS	NNS	_	26	nmod	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	necessary	necessary	JJ	JJ	_	34	amod	_	_
37	for	for	IN	IN	_	39	case	_	_
38	CD18	cd18	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	Evaluation	evaluation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	respiratory	respiratory	JJ	JJ	_	5	amod	_	_
5	epithelium	epithelium	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	normals	normal	NNS	NNS	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	individuals	individual	NNS	NNS	_	7	conj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	cystic	cystic	JJ	JJ	_	12	amod	_	_
12	fibrosis	fibrosis	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	1	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	adenovirus	adenovirus	NN	NN	_	19	compound	_	_
18	E1a	e1a	NN	NN	_	19	compound	_	_
19	sequences	sequence	NNS	NNS	_	15	nmod	_	_
20	relevant	relevant	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	use	use	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	E1a-	e1a-	JJ	JJ	_	27	amod	_	_
26	adenovirus	adenovirus	NN	NN	_	27	compound	_	_
27	vectors	vector	NNS	NNS	_	23	nmod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	therapy	therapy	NN	NN	_	23	nmod	_	_
31	for	for	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	respiratory	respiratory	JJ	JJ	_	34	amod	_	_
34	manifestations	manifestation	NNS	NNS	_	30	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	cystic	cystic	JJ	JJ	_	37	amod	_	_
37	fibrosis	fibrosis	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	1	punct	_	_

1	Lung	lung	NN	NN	_	2	compound	_	_
2	disease	disease	NN	NN	_	15	nsubj	_	_
3	associated	associate	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	5	case	_	_
5	disorders	disorder	NNS	NNS	_	3	nmod	_	_
6	such	such	JJ	JJ	_	9	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	cystic	cystic	JJ	JJ	_	9	amod	_	_
9	fibrosis	fibrosis	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CF	cf	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	amenable	amenable	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	19	case	_	_
17	somatic	somatic	JJ	JJ	_	19	amod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	which	which	WDT	WDT	_	23	nmod	_	_
22	there	there	EX	EX	_	23	expl	_	_
23	is	be	VBZ	VBZ	_	19	acl:relcl	_	_
24	delivery	delivery	NN	NN	_	23	nsubj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	gene	gene	NN	NN	_	24	nmod	_	_
29	directly	directly	RB	RB	_	24	advmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	respiratory	respiratory	JJ	JJ	_	33	amod	_	_
33	epithelium	epithelium	NN	NN	_	24	nmod	_	_
34	using	use	VBG	VBG	_	24	acl	_	_
35	E1a-	e1a-	JJ	JJ	_	36	amod	_	_
36	adenovirus	adenovirus	NN	NN	_	34	dobj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	Ad	ad	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	type	type	NN	NN	_	36	dep	_	_
41	2-	2-	CD	CD	_	40	nummod	_	_
42	or	or	CC	CC	_	36	cc	_	_
43	5-based	5-based	JJ	JJ	_	36	conj	_	_
44	vectors	vector	NNS	NNS	_	36	dep	_	_
45	.	.	.	.	_	15	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	safety	safety	NN	NN	_	3	compound	_	_
3	reasons	reason	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Ad	ad	NN	NN	_	7	compound	_	_
7	vectors	vector	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	rendered	render	VBN	VBN	_	0	root	_	_
10	replication	replication	NN	NN	_	11	nmod:npmod	_	_
11	deficient	deficient	JJ	JJ	_	9	xcomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	deletion	deletion	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	E1a	e1a	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	3	mark	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	is	be	VBZ	VBZ	_	34	advcl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	theoretical	theoretical	JJ	JJ	_	6	amod	_	_
6	possibility	possibility	NN	NN	_	3	nsubj	_	_
7	of	of	IN	IN	_	12	mark	_	_
8	an	a	DT	DT	_	11	det	_	_
9	E1a-	e1a-	JJ	JJ	_	11	amod	_	_
10	replication-deficient	replication-deficient	JJ	JJ	_	11	amod	_	_
11	vector	vector	NN	NN	_	12	nsubj	_	_
12	replicating	replicate	VBG	VBG	_	6	acl	_	_
13	as	as	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	result	result	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	recombination	recombination	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	complementation	complementation	NN	NN	_	17	conj	_	_
20	with	with	IN	IN	_	24	case	_	_
21	Ad	ad	NN	NN	_	24	compound	_	_
22	2/5	2/5	CD	CD	_	24	nummod	_	_
23	E1a	e1a	NN	NN	_	24	compound	_	_
24	sequences	sequence	NNS	NNS	_	17	nmod	_	_
25	present	present	JJ	JJ	_	24	amod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	target	target	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	34	punct	_	_
31	this	this	DT	DT	_	32	det	_	_
32	study	study	NN	NN	_	34	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	directed	direct	VBN	VBN	_	0	root	_	_
35	toward	toward	IN	IN	_	36	mark	_	_
36	evaluating	evaluate	VBG	VBG	_	34	advcl	_	_
37	respiratory	respiratory	NN	NN	_	38	compound	_	_
38	epithelium	epithelium	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	normals	normal	NNS	NNS	_	38	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	individuals	individual	NNS	NNS	_	40	conj	_	_
43	with	with	IN	IN	_	44	case	_	_
44	CF	cf	NN	NN	_	42	nmod	_	_
45	for	for	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	presence	presence	NN	NN	_	36	nmod	_	_
48	of	of	IN	IN	_	50	case	_	_
49	E1a	e1a	NN	NN	_	50	compound	_	_
50	sequences	sequence	NNS	NNS	_	47	nmod	_	_
51	.	.	.	.	_	34	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	Ad	ad	NN	NN	_	5	compound	_	_
3	2/5	2/5	CD	CD	_	5	nummod	_	_
4	E1a-specific	e1a-specific	JJ	JJ	_	5	amod	_	_
5	primers	primer	NNS	NNS	_	1	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	10	det	_	_
8	polymerase	polymerase	NN	NN	_	10	compound	_	_
9	chain	chain	NN	NN	_	10	compound	_	_
10	reaction	reaction	NN	NN	_	5	conj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	evaluate	evaluate	VB	VB	_	1	advcl	_	_
13	DNA	dna	NN	NN	_	12	dobj	_	_
14	recovered	recover	VBN	VBN	_	13	acl	_	_
15	from	from	IN	IN	_	18	case	_	_
16	freshly	freshly	RB	RB	_	17	advmod	_	_
17	isolated	isolate	VBN	VBN	_	18	amod	_	_
18	nasal	nasal	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	bronchial	bronchial	JJ	JJ	_	18	conj	_	_
21	epithelium	epithelium	NN	NN	_	18	dep	_	_
22	recovered	recover	VBN	VBN	_	18	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	brushing	brushing	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	1	punct	_	_
26	E1a	e1a	NN	NN	_	27	compound	_	_
27	sequences	sequence	NNS	NNS	_	29	nsubjpass	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	detected	detect	VBN	VBN	_	1	parataxis	_	_
30	in	in	IN	IN	_	32	case	_	_
31	respiratory	respiratory	JJ	JJ	_	32	amod	_	_
32	epithelium	epithelium	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	19	19	CD	CD	_	36	compound	_	_
35	of	of	IN	IN	_	36	advmod	_	_
36	91	91	CD	CD	_	37	nummod	_	_
37	normals	normal	NNS	NNS	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	21	21	CD	CD	_	40	nummod	_	_
40	%	%	NN	NN	_	37	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	E1a-positive	e1a-positive	JJ	JJ	_	4	amod	_	_
4	samples	sample	NNS	NNS	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	average	average	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	E1a	e1a	NN	NN	_	11	compound	_	_
10	copy	copy	NN	NN	_	11	compound	_	_
11	number	number	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	17	cop	_	_
13	55	55	CD	CD	_	17	nummod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	18/10(3)	18/10(3)	CD	CD	_	13	conj	_	_
16	recovered	recover	VBN	VBN	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	CF	cf	NN	NN	_	3	compound	_	_
3	individuals	individual	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	7	7	CD	CD	_	7	compound	_	_
6	of	of	IN	IN	_	7	advmod	_	_
7	52	52	CD	CD	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	13	13	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	had	have	VBD	VBD	_	0	root	_	_
13	detectable	detectable	JJ	JJ	_	15	amod	_	_
14	E1a	e1a	NN	NN	_	15	compound	_	_
15	sequences	sequence	NNS	NNS	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	respiratory	respiratory	JJ	JJ	_	19	amod	_	_
19	epithelium	epithelium	NN	NN	_	12	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	with	with	IN	IN	_	24	case	_	_
22	E1a	e1a	NN	NN	_	24	compound	_	_
23	copy	copy	NN	NN	_	24	compound	_	_
24	number	number	NN	NN	_	12	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	positive	positive	JJ	JJ	_	28	amod	_	_
28	samples	sample	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	34	case	_	_
30	80	80	CD	CD	_	34	nummod	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	21/10(3)	21/10(3)	CD	CD	_	30	conj	_	_
33	recovered	recover	VBN	VBN	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	are	be	VBP	VBP	_	3	ccomp	_	_
7	detectable	detectable	JJ	JJ	_	11	amod	_	_
8	Ad	ad	NN	NN	_	11	compound	_	_
9	2/5	2/5	CD	CD	_	11	nummod	_	_
10	E1a	e1a	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	6	nsubj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	respiratory	respiratory	JJ	JJ	_	15	amod	_	_
15	epithelium	epithelium	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	small	small	JJ	JJ	_	19	amod	_	_
19	percentage	percentage	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	normals	normal	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	individuals	individual	NNS	NNS	_	21	conj	_	_
24	with	with	IN	IN	_	25	case	_	_
25	CF	cf	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	5	case	_	_
2	of	of	IN	IN	_	1	mwe	_	_
3	the	the	DT	DT	_	5	det	_	_
4	theoretical	theoretical	JJ	JJ	_	5	amod	_	_
5	potential	potential	NN	NN	_	26	nmod	_	_
6	of	of	IN	IN	_	9	mark	_	_
7	such	such	JJ	JJ	_	8	amod	_	_
8	sequences	sequence	NNS	NNS	_	9	nsubj	_	_
9	supporting	support	VBG	VBG	_	5	acl	_	_
10	replication	replication	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	E1a-	e1a-	JJ	JJ	_	14	amod	_	_
13	Ad	ad	NN	NN	_	14	compound	_	_
14	vectors	vector	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	26	punct	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	gene	gene	NN	NN	_	19	compound	_	_
18	therapy	therapy	NN	NN	_	19	compound	_	_
19	protocols	protocol	NNS	NNS	_	26	nsubj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	CF	cf	NN	NN	_	19	nmod	_	_
22	utilizing	utilize	VBG	VBG	_	19	acl	_	_
23	such	such	JJ	JJ	_	24	amod	_	_
24	vectors	vector	NNS	NNS	_	22	dobj	_	_
25	should	should	MD	MD	_	26	aux	_	_
26	consider	consider	VB	VB	_	0	root	_	_
27	evaluating	evaluate	VBG	VBG	_	26	xcomp	_	_
28	study	study	NN	NN	_	29	compound	_	_
29	individuals	individual	NNS	NNS	_	27	dobj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	presence	presence	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	Ad	ad	NN	NN	_	37	compound	_	_
35	2/5	2/5	CD	CD	_	37	nummod	_	_
36	E1a	e1a	NN	NN	_	37	compound	_	_
37	sequences	sequence	NNS	NNS	_	32	nmod	_	_
38	in	in	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	respiratory	respiratory	JJ	JJ	_	41	amod	_	_
41	epithelium	epithelium	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	26	punct	_	_

1	Biphasic	biphasic	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	2	nmod	_	_
14	:	:	:	:	_	2	punct	_	_
15	role	role	NN	NN	_	2	dep	_	_
16	of	of	IN	IN	_	20	case	_	_
17	tumor	tumor	NN	NN	_	20	compound	_	_
18	necrosis	necrosis	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	29	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
5	factor	factor	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	NF	nf	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	-kappa	-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	2	nmod	_	_
12	by	by	IN	IN	_	21	case	_	_
13	the	the	DT	DT	_	21	det	_	_
14	T	t	NN	NN	_	21	compound	_	_
15	cell	cell	NN	NN	_	21	compound	_	_
16	receptor	receptor	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	TcR	tcr	NN	NN	_	21	compound	_	_
19	)	)	-RRB-	-RRB-	_	21	punct	_	_
20	/CD3	/cd3	NN	NN	_	21	compound	_	_
21	complex	complex	NN	NN	_	11	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	primary	primary	JJ	JJ	_	26	amod	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	11	nmod	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	studied	study	VBN	VBN	_	0	root	_	_
30	at	at	IN	IN	_	32	case	_	_
31	various	various	JJ	JJ	_	32	amod	_	_
32	times	time	NNS	NNS	_	29	nmod	_	_
33	after	after	IN	IN	_	34	case	_	_
34	activation	activation	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	29	punct	_	_

1	Only	only	RB	RB	_	5	advmod	_	_
2	p50	p50	NN	NN	_	5	compound	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	nsubj	_	_
6	bound	bind	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	19	case	_	_
12	interleukin-2	interleukin-2	NN	NN	_	19	compound	_	_
13	receptor	receptor	NN	NN	_	19	compound	_	_
14	(	(	-LRB-	-LRB-	_	19	punct	_	_
15	IL-2R	il-2r	NN	NN	_	19	compound	_	_
16	)	)	-RRB-	-RRB-	_	19	punct	_	_
17	alpha	alpha	NN	NN	_	19	compound	_	_
18	chain	chain	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	10	nmod	_	_
20	on	on	IN	IN	_	23	case	_	_
21	resting	rest	VBG	VBG	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	6	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	immediately	immediately	RB	RB	_	20	advmod	_	_
4	after	after	IN	IN	_	5	case	_	_
5	TcR/CD3	tcr/cd3	NN	NN	_	20	advcl	_	_
6	cross-linking	cross-linking	JJ	JJ	_	5	amod	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	after	after	IN	IN	_	11	case	_	_
9	approximately	approximately	RB	RB	_	10	advmod	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	5	dep	_	_
12	;	;	:	:	_	11	punct	_	_
13	immediate	immediate	JJ	JJ	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	binding	binding	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	p50.p65	p50.p65	NN	NN	_	18	compound	_	_
18	heterodimers	heterodimer	NNS	NNS	_	15	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	observed	observe	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	p50.c-rel	p50.c-rel	NN	NN	_	2	compound	_	_
2	heterodimers	heterodimer	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	bound	bind	VBN	VBN	_	5	dep	_	_
7	to	to	TO	TO	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	sequence	sequence	NN	NN	_	6	nmod	_	_
10	at	at	IN	IN	_	13	case	_	_
11	early	early	JJ	JJ	_	13	amod	_	_
12	time	time	NN	NN	_	13	compound	_	_
13	points	point	NNS	NNS	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	7-16	7-16	CD	CD	_	16	nummod	_	_
16	h	h	NN	NN	_	13	dep	_	_
17	;	;	:	:	_	16	punct	_	_
18	early	early	RB	RB	_	16	amod	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	,	,	,	,	_	5	punct	_	_
21	and	and	CC	CC	_	5	cc	_	_
22	both	both	DT	DT	_	23	nsubj	_	_
23	remained	remain	VBD	VBD	_	5	conj	_	_
24	active	active	JJ	JJ	_	23	xcomp	_	_
25	at	at	IN	IN	_	28	case	_	_
26	later	later	JJR	JJR	_	28	amod	_	_
27	time	time	NN	NN	_	28	compound	_	_
28	points	point	NNS	NNS	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	40	40	CD	CD	_	31	nummod	_	_
31	h	h	NN	NN	_	28	dep	_	_
32	;	;	:	:	_	31	punct	_	_
33	late	late	RB	RB	_	31	amod	_	_
34	)	)	-RRB-	-RRB-	_	31	punct	_	_
35	after	after	IN	IN	_	36	case	_	_
36	activation	activation	NN	NN	_	28	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	3	nsubj	_	_
3	takes	take	VBZ	VBZ	_	0	root	_	_
4	place	place	NN	NN	_	3	dobj	_	_
5	mainly	mainly	RB	RB	_	3	advcl	_	_
6	at	at	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	level	level	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p65	p65	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-rel	c-rel	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	at	at	IN	IN	_	18	case	_	_
18	immediate	immediate	JJ	JJ	_	5	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	early	early	JJ	JJ	_	18	conj	_	_
21	time	time	NN	NN	_	22	compound	_	_
22	points	point	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	c-rel	c-rel	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p105/p50	p105/p50	NN	NN	_	4	conj	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	synthesis	synthesis	NN	NN	_	4	dep	_	_
9	,	,	,	,	_	4	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	4	cc	_	_
12	p65	p65	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	4	conj	_	_
14	whose	whose	WP$	WP$	_	15	nmod:poss	_	_
15	expression	expression	NN	NN	_	17	nsubj	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	constitutive	constitutive	JJ	JJ	_	13	acl:relcl	_	_
18	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	all	all	PDT	PDT	_	5	dep	_	_
4	those	those	DT	DT	_	5	dep	_	_
5	early	early	JJ	JJ	_	17	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	late	late	JJ	JJ	_	5	conj	_	_
8	events	event	NNS	NNS	_	5	dep	_	_
9	,	,	,	,	_	5	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	5	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	immediate	immediate	JJ	JJ	_	14	amod	_	_
14	ones	one	NNS	NNS	_	5	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	inhibited	inhibit	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	29	case	_	_
19	a	a	DT	DT	_	29	det	_	_
20	neutralizing	neutralize	VBG	VBG	_	29	amod	_	_
21	anti-tumor	anti-tumor	JJ	JJ	_	29	amod	_	_
22	necrosis	necrosis	NN	NN	_	29	compound	_	_
23	factor	factor	NN	NN	_	29	compound	_	_
24	alpha	alpha	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	monoclonal	monoclonal	JJ	JJ	_	29	amod	_	_
29	antibody	antibody	NN	NN	_	17	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	Similarly	similarly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	cycloheximide	cycloheximide	NN	NN	_	4	nsubj	_	_
4	prevented	prevent	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	dep	_	_
6	p65	p65	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-rel	c-rel	NN	NN	_	6	conj	_	_
9	translocation	translocation	NN	NN	_	6	dep	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	consequent	consequent	JJ	JJ	_	12	amod	_	_
12	formation	formation	NN	NN	_	6	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	active	active	JJ	JJ	_	16	amod	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	heterodimers	heterodimer	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	at	at	IN	IN	_	19	case	_	_
19	early	early	JJ	JJ	_	4	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	late	late	JJ	JJ	_	19	conj	_	_
22	times	time	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	4	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	nsubj	_	_
3	impaired	impair	VBD	VBD	_	0	root	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	only	only	RB	RB	_	6	cc:preconj	_	_
6	early	early	JJ	JJ	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	late	late	JJ	JJ	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	but	but	CC	CC	_	6	cc	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	immediate	immediate	JJ	JJ	_	6	conj	_	_
13	events	event	NNS	NNS	_	6	dep	_	_
14	;	;	:	:	_	3	punct	_	_
15	however	however	RB	RB	_	20	advmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	addition	addition	NN	NN	_	20	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	17	nmod	_	_
20	prevented	prevent	VBD	VBD	_	3	parataxis	_	_
21	all	all	DT	DT	_	22	det	_	_
22	inhibition	inhibition	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	regulation	regulation	NN	NN	_	19	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	during	during	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	6	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	TcR/CD3	tcr/cd3	NN	NN	_	17	compound	_	_
17	signals	signal	NNS	NNS	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	biphasic	biphasic	JJ	JJ	_	3	ccomp	_	_
20	:	:	:	:	_	3	punct	_	_
21	TcR/CD3	tcr/cd3	NN	NN	_	22	nsubj	_	_
22	triggers	trigger	VBZ	VBZ	_	3	parataxis	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	immediate	immediate	JJ	JJ	_	25	amod	_	_
25	translocation	translocation	NN	NN	_	22	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	which	which	WDT	WDT	_	29	nsubj	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	transient	transient	JJ	JJ	_	25	acl:relcl	_	_
30	if	if	IN	IN	_	34	mark	_	_
31	no	no	DT	DT	_	32	neg	_	_
32	TNF-alpha	tnf-alpha	NN	NN	_	34	nsubj	_	_
33	is	be	VBZ	VBZ	_	34	cop	_	_
34	present	present	JJ	JJ	_	29	advcl	_	_
35	.	.	.	.	_	3	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	5	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	emerges	emerge	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	main	main	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	nmod	_	_
10	responsible	responsible	JJ	JJ	_	9	amod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	second	second	JJ	JJ	_	14	amod	_	_
14	phase	phase	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	regulation	regulation	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	controlling	control	VBG	VBG	_	5	xcomp	_	_
21	both	both	CC	CC	_	22	cc:preconj	_	_
22	translocation	translocation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p65	p65	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	c-rel	c-rel	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	new	new	JJ	JJ	_	31	amod	_	_
30	mRNA	mrna	NN	NN	_	31	compound	_	_
31	synthesis	synthesis	NN	NN	_	22	conj	_	_
32	for	for	IN	IN	_	33	case	_	_
33	c-rel	c-rel	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	p105/p50	p105/p50	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	not	not	RB	RB	_	8	neg	_	_
6	a	a	DT	DT	_	8	det	_	_
7	downstream	downstream	JJ	JJ	_	8	amod	_	_
8	effector	effector	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	p21ras	p21ras	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	investigate	investigate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PKC	pkc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	downstream	downstream	JJ	JJ	_	15	advmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	p21ras	p21ras	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	in	in	IN	IN	_	25	mark	_	_
25	activating	activate	VBG	VBG	_	15	acl	_	_
26	interleukin-2	interleukin-2	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	IL-2	il-2	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	25	dobj	_	_
32	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	PKC	pkc	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	an	a	DT	DT	_	9	det	_	_
9	effector	effector	NN	NN	_	4	ccomp	_	_
10	of	of	IN	IN	_	11	case	_	_
11	p21ras	p21ras	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Data	datum	NNS	NNS	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	presented	present	VBN	VBN	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	using	use	VBG	VBG	_	3	advcl	_	_
6	the	the	DT	DT	_	11	det	_	_
7	potent	potent	JJ	JJ	_	11	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	selective	selective	JJ	JJ	_	7	conj	_	_
10	PKC	pkc	NN	NN	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	5	dobj	_	_
12	Ro	ro	NN	NN	_	11	dep	_	_
13	31-8425	31-8425	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	transient	transient	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	constitutively	constitutively	RB	RB	_	20	advmod	_	_
20	active	active	JJ	JJ	_	21	amod	_	_
21	ras	ras	NN	NN	_	16	nmod	_	_
22	mutant	mutant	JJ	JJ	_	21	amod	_	_
23	,	,	,	,	_	3	punct	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	clearly	clearly	RB	RB	_	26	advmod	_	_
26	shows	show	VBZ	VBZ	_	3	dep	_	_
27	that	that	IN	IN	_	36	mark	_	_
28	PKC	pkc	NN	NN	_	36	nsubj	_	_
29	is	be	VBZ	VBZ	_	36	cop	_	_
30	not	not	RB	RB	_	36	neg	_	_
31	downstream	downstream	JJ	JJ	_	36	advmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	p21ras	p21ras	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	induction	induction	NN	NN	_	26	ccomp	_	_
37	of	of	IN	IN	_	38	case	_	_
38	NF-AT	nf-at	NN	NN	_	36	nmod	_	_
39	and	and	CC	CC	_	36	cc	_	_
40	AP-1	ap-1	NN	NN	_	42	compound	_	_
41	transcriptional	transcriptional	JJ	JJ	_	42	amod	_	_
42	activity	activity	NN	NN	_	36	conj	_	_
43	and	and	CC	CC	_	36	cc	_	_
44	in	in	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	expression	expression	NN	NN	_	36	conj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	IL-2	il-2	NN	NN	_	46	nmod	_	_
49	in	in	IN	IN	_	53	case	_	_
50	human	human	JJ	JJ	_	53	amod	_	_
51	Jurkat	jurkat	NN	NN	_	53	compound	_	_
52	T	t	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	46	nmod	_	_
54	.	.	.	.	_	3	punct	_	_

1	Reporter	reporter	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	affected	affect	VBN	VBN	_	4	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	expression	expression	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	activated	activate	VBN	VBN	_	17	amod	_	_
17	p21ras	p21ras	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	signaling	signaling	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	13	nsubj	_	_
4	involving	involve	VBG	VBG	_	3	acl	_	_
5	PKC	pkc	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	calcium	calcium	NN	NN	_	9	compound	_	_
9	mobilization	mobilization	NN	NN	_	6	conj	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	ras	ras	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	6	conj	_	_
13	combine	combine	VBP	VBP	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	provide	provide	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	necessary	necessary	JJ	JJ	_	18	amod	_	_
18	components	component	NNS	NNS	_	15	dobj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	production	production	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IL-2	il-2	NN	NN	_	20	nmod	_	_
23	during	during	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Association	association	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	alterations	alteration	NNS	NNS	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	moieties	moiety	NNS	NNS	_	3	nmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	HIV	hiv	NN	NN	_	13	compound	_	_
10	type	type	NN	NN	_	13	compound	_	_
11	1	1	CD	CD	_	13	nummod	_	_
12	proviral	proviral	JJ	JJ	_	13	amod	_	_
13	latency	latency	NN	NN	_	1	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	certain	certain	JJ	JJ	_	17	amod	_	_
16	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	9	compound	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	replication	replication	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	controlled	control	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	complex	complex	JJ	JJ	_	15	amod	_	_
15	array	array	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	virally	virally	RB	RB	_	18	advmod	_	_
18	encoded	encode	VBN	VBN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cellular	cellular	JJ	JJ	_	18	conj	_	_
21	proteins	protein	NNS	NNS	_	18	dep	_	_
22	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	wide	wide	JJ	JJ	_	3	amod	_	_
3	spectrum	spectrum	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	levels	level	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	various	various	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	both	both	CC	CC	_	11	dep	_	_
17	in	in	IN	IN	_	19	case	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	culture	culture	NN	NN	_	16	dep	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	16	conj	_	_
23	.	.	.	.	_	11	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	9	nsubj	_	_
3	leading	lead	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	7	case	_	_
5	restricted	restricted	JJ	JJ	_	7	amod	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	replication	replication	NN	NN	_	3	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	differ	differ	VB	VB	_	0	root	_	_
10	between	between	IN	IN	_	13	case	_	_
11	certain	certain	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	types	type	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	34	mark	_	_
6	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
7	proviral	proviral	JJ	JJ	_	8	amod	_	_
8	latency	latency	NN	NN	_	34	nsubjpass	_	_
9	in	in	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	line	line	NN	NN	_	14	compound	_	_
14	U1	u1	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	in	in	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	26	nmod	_	_
18	only	only	RB	RB	_	20	advmod	_	_
19	extremely	extremely	RB	RB	_	20	advmod	_	_
20	low	low	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	26	nsubjpass	_	_
22	of	of	IN	IN	_	24	case	_	_
23	HIV-1	hiv-1	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	detected	detect	VBN	VBN	_	14	acl:relcl	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	baseline	baseline	NN	NN	_	31	compound	_	_
30	unstimulated	unstimulated	JJ	JJ	_	31	amod	_	_
31	state	state	NN	NN	_	26	nmod	_	_
32	,	,	,	,	_	8	punct	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	associated	associate	VBN	VBN	_	4	ccomp	_	_
35	with	with	IN	IN	_	36	case	_	_
36	alterations	alteration	NNS	NNS	_	34	nmod	_	_
37	in	in	IN	IN	_	45	case	_	_
38	nuclear	nuclear	JJ	JJ	_	45	amod	_	_
39	factor-kappa	factor-kappa	NN	NN	_	45	compound	_	_
40	B	b	NN	NN	_	45	compound	_	_
41	(	(	-LRB-	-LRB-	_	45	punct	_	_
42	NF-kappa	nf-kappa	NN	NN	_	45	compound	_	_
43	B	b	NN	NN	_	45	compound	_	_
44	)	)	-RRB-	-RRB-	_	45	punct	_	_
45	moieties	moiety	NNS	NNS	_	36	nmod	_	_
46	demonstrated	demonstrate	VBN	VBN	_	36	acl	_	_
47	in	in	IN	IN	_	49	case	_	_
48	these	these	DT	DT	_	49	det	_	_
49	cells	cell	NNS	NNS	_	46	nmod	_	_
50	by	by	IN	IN	_	54	case	_	_
51	electrophoretic	electrophoretic	JJ	JJ	_	54	amod	_	_
52	mobility	mobility	NN	NN	_	54	compound	_	_
53	shift	shift	NN	NN	_	54	compound	_	_
54	assays	assay	NNS	NNS	_	46	nmod	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	EMSAs	emsa	NNS	NNS	_	54	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	and	and	CC	CC	_	54	cc	_	_
59	in	in	FW	FW	_	63	amod	_	_
60	situ	situ	FW	FW	_	59	dep	_	_
61	UV	uv	NN	NN	_	63	compound	_	_
62	cross-linking	cross-linking	JJ	JJ	_	63	amod	_	_
63	studies	study	NNS	NNS	_	54	conj	_	_
64	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	predominance	predominance	NN	NN	_	41	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	p50	p50	NN	NN	_	7	compound	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	moieties	moiety	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	possibly	possibly	RB	RB	_	11	advmod	_	_
10	p50	p50	NN	NN	_	11	compound	_	_
11	homodimers	homodimer	NNS	NNS	_	7	conj	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	closely	closely	RB	RB	_	14	advmod	_	_
14	related	related	JJ	JJ	_	15	amod	_	_
15	species	species	NNS	NNS	_	11	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	rather	rather	RB	RB	_	7	cc	_	_
18	than	than	IN	IN	_	17	mwe	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p50-p56	p50-p56	NN	NN	_	21	compound	_	_
21	heterodimer	heterodimer	NN	NN	_	7	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	that	that	WDT	WDT	_	31	nsubj	_	_
26	is	be	VBZ	VBZ	_	31	cop	_	_
27	the	the	DT	DT	_	31	det	_	_
28	predominant	predominant	JJ	JJ	_	31	amod	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	species	species	NNS	NNS	_	21	acl:relcl	_	_
32	in	in	IN	IN	_	35	case	_	_
33	most	most	JJS	JJS	_	35	amod	_	_
34	T	t	NN	NN	_	35	nmod:npmod	_	_
35	lymphocytic	lymphocytic	JJ	JJ	_	31	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	monocytic	monocytic	JJ	JJ	_	35	conj	_	_
38	cells	cell	NNS	NNS	_	35	dep	_	_
39	,	,	,	,	_	2	punct	_	_
40	is	be	VBZ	VBZ	_	41	auxpass	_	_
41	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	nuclei	nucleus	NNS	NNS	_	41	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	U1	u1	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	44	nmod	_	_
48	.	.	.	.	_	41	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B-related	b-related	JJ	JJ	_	6	amod	_	_
6	moieties	moiety	NNS	NNS	_	2	nmod	_	_
7	differs	differ	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	det	_	_
10	latently	latently	RB	RB	_	16	advmod	_	_
11	infected	infected	JJ	JJ	_	16	amod	_	_
12	T	t	NN	NN	_	16	compound	_	_
13	lymphocytic	lymphocytic	JJ	JJ	_	16	amod	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	line	line	NN	NN	_	16	compound	_	_
16	ACH-2	ach-2	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	from	from	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	U937	u937	NN	NN	_	23	compound	_	_
22	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
23	line	line	NN	NN	_	16	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	the	the	DT	DT	_	28	det	_	_
26	parental	parental	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	23	appos	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	U1	u1	NN	NN	_	33	compound	_	_
32	cellular	cellular	JJ	JJ	_	33	amod	_	_
33	clone	clone	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	As	as	IN	IN	_	2	case	_	_
2	such	such	JJ	JJ	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	different	different	JJ	JJ	_	10	amod	_	_
9	proximal	proximal	JJ	JJ	_	8	dep	_	_
10	mechanisms	mechanism	NNS	NNS	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	lead	lead	VB	VB	_	6	ccomp	_	_
13	to	to	TO	TO	_	16	case	_	_
14	restricted	restricted	JJ	JJ	_	16	amod	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	various	various	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Overexpression	overexpression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	protein	protein	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	C-zeta	c-zeta	NN	NN	_	1	nmod	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	leukemic	leukemic	JJ	JJ	_	8	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	6	dobj	_	_
10	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	28	nsubjpass	_	_
3	for	for	IN	IN	_	6	case	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	C-zeta	c-zeta	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PKC-zeta	pkc-zeta	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	member	member	NN	NN	_	6	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	12	nmod	_	_
17	nonresponsive	nonresponsive	JJ	JJ	_	16	amod	_	_
18	atypical	atypical	JJ	JJ	_	17	dep	_	_
19	protein	protein	NN	NN	_	22	compound	_	_
20	kinase	kinase	NN	NN	_	22	compound	_	_
21	C	c	NN	NN	_	22	compound	_	_
22	subfamily	subfamily	NN	NN	_	16	dep	_	_
23	,	,	,	,	_	2	punct	_	_
24	in	in	IN	IN	_	25	mark	_	_
25	modulating	modulate	VBG	VBG	_	2	acl	_	_
26	differentiation	differentiation	NN	NN	_	25	dobj	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	examined	examine	VBN	VBN	_	0	root	_	_
29	in	in	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	leukemic	leukemic	JJ	JJ	_	33	amod	_	_
32	U937	u937	NN	NN	_	33	compound	_	_
33	cell	cell	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	28	punct	_	_

1	Transfected	transfect	VBN	VBN	_	3	amod	_	_
2	U937	u937	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nsubj	_	_
4	stably	stably	RB	RB	_	5	advmod	_	_
5	overexpressing	overexpress	VBG	VBG	_	3	acl	_	_
6	PKC-zeta	pkc-zeta	NN	NN	_	5	dobj	_	_
7	displayed	display	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	longer	longer	RBR	RBR	_	11	advmod	_	_
10	doubling	doubling	JJ	JJ	_	11	amod	_	_
11	time	time	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	lower	lower	JJR	JJR	_	15	amod	_	_
14	saturation	saturation	NN	NN	_	15	compound	_	_
15	density	density	NN	NN	_	11	conj	_	_
16	at	at	IN	IN	_	17	case	_	_
17	confluency	confluency	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	an	a	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	11	conj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	adherence	adherence	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	plastic	plastic	JJ	JJ	_	23	nmod	_	_
26	as	as	IN	IN	_	27	mark	_	_
27	compared	compare	VBN	VBN	_	7	advcl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	control	control	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	PKC-zeta	pkc-zeta	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	expressed	express	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	differentiated	differentiate	VBN	VBN	_	7	amod	_	_
7	phenotype	phenotype	NN	NN	_	3	dobj	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	assessed	assess	VBN	VBN	_	3	advcl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	changes	change	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	morphology	morphology	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	surface	surface	NN	NN	_	17	compound	_	_
16	antigen	antigen	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	lysosomal	lysosomal	JJ	JJ	_	21	amod	_	_
21	enzyme	enzyme	NN	NN	_	22	compound	_	_
22	activities	activity	NNS	NNS	_	11	conj	_	_
23	and	and	CC	CC	_	3	cc	_	_
24	were	be	VBD	VBD	_	25	cop	_	_
25	distinct	distinct	JJ	JJ	_	3	conj	_	_
26	from	from	IN	IN	_	29	case	_	_
27	parental	parental	JJ	JJ	_	29	amod	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	stimulated	stimulate	VBN	VBN	_	29	acl	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	differentiate	differentiate	VB	VB	_	30	xcomp	_	_
33	by	by	IN	IN	_	34	case	_	_
34	exposure	exposure	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	37	case	_	_
36	phorbol	phorbol	NN	NN	_	37	compound	_	_
37	esters	ester	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	parental	parental	JJ	JJ	_	6	amod	_	_
5	U937	u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	PKC-zeta	pkc-zeta	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	11	nsubj	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	expressed	express	VBD	VBD	_	0	root	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	11	dobj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	c-jun	c-jun	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	a	a	DT	DT	_	22	det	_	_
18	low	low	JJ	JJ	_	22	amod	_	_
19	mobility	mobility	NN	NN	_	22	compound	_	_
20	AP-1	ap-1	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	15	conj	_	_
23	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PKC-zeta	pkc-zeta	NN	NN	_	4	compound	_	_
4	overexpression	overexpression	NN	NN	_	5	nsubj	_	_
5	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	type	type	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	phenotypic	phenotypic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	differs	differ	VBZ	VBZ	_	7	acl:relcl	_	_
13	significantly	significantly	RB	RB	_	12	advmod	_	_
14	from	from	IN	IN	_	15	case	_	_
15	maturation	maturation	NN	NN	_	12	nmod	_	_
16	occurring	occur	VBG	VBG	_	15	acl	_	_
17	upon	upon	IN	IN	_	18	case	_	_
18	activation	activation	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	other	other	JJ	JJ	_	22	amod	_	_
21	PKC	pkc	NN	NN	_	22	compound	_	_
22	subfamilies	subfamily	NNS	NNS	_	18	nmod	_	_
23	induced	induce	VBN	VBN	_	18	acl	_	_
24	by	by	IN	IN	_	27	case	_	_
25	phorbol	phorbol	NN	NN	_	27	compound	_	_
26	ester	ester	NN	NN	_	27	compound	_	_
27	treatment	treatment	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	c-jun	c-jun	NN	NN	_	6	compound	_	_
6	protooncogene	protooncogene	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	an	a	DT	DT	_	9	det	_	_
9	increase	increase	NN	NN	_	2	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	AP-1	ap-1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	PKC-zeta	pkc-zeta	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	2	nmod	_	_
17	provides	provide	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	potential	potential	JJ	JJ	_	20	amod	_	_
20	mechanism	mechanism	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	22	mark	_	_
22	explaining	explain	VBG	VBG	_	20	acl	_	_
23	the	the	DT	DT	_	26	det	_	_
24	altered	altered	JJ	JJ	_	26	amod	_	_
25	differentiation	differentiation	NN	NN	_	26	compound	_	_
26	status	status	NN	NN	_	22	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	cell	cell	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	Alteration	alteration	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	structural	structural	JJ	JJ	_	4	amod	_	_
4	order	order	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	erythrocyte	erythrocyte	NN	NN	_	9	compound	_	_
8	ghost	ghost	NN	NN	_	9	compound	_	_
9	membrane	membrane	NN	NN	_	4	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
12	and	and	CC	CC	_	1	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	influence	influence	NN	NN	_	1	conj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	antagonist	antagonist	NN	NN	_	20	compound	_	_
20	RU	ru	NN	NN	_	14	nmod	_	_
21	486	486	CD	CD	_	20	nummod	_	_
22	.	.	.	.	_	1	punct	_	_

1	High-dose	high-dose	JJ	JJ	_	4	amod	_	_
2	pulse	pulse	NN	NN	_	4	compound	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	therapy	therapy	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	successfully	successfully	RB	RB	_	7	advmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	clinic	clinic	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	severe	severe	JJ	JJ	_	15	amod	_	_
14	pathological	pathological	JJ	JJ	_	15	amod	_	_
15	conditions	condition	NNS	NNS	_	7	nmod	_	_
16	for	for	IN	IN	_	19	case	_	_
17	about	about	RB	RB	_	18	advmod	_	_
18	20	20	CD	CD	_	19	nummod	_	_
19	years	year	NNS	NNS	_	7	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mode	mode	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	action	action	NN	NN	_	2	nmod	_	_
6	after	after	IN	IN	_	7	case	_	_
7	administration	administration	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	such	such	JJ	JJ	_	10	amod	_	_
10	megadoses	megadose	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	inexplicable	inexplicable	JJ	JJ	_	0	root	_	_
13	up	up	RP	RP	_	15	dep	_	_
14	to	to	TO	TO	_	15	case	_	_
15	now	now	RB	RB	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	supposed	suppose	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	some	some	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	12	nsubj	_	_
7	may	may	MD	MD	_	12	aux	_	_
8	be	be	VB	VB	_	12	cop	_	_
9	due	due	JJ	JJ	_	12	case	_	_
10	to	to	TO	TO	_	9	mwe	_	_
11	membrane	membrane	NN	NN	_	12	compound	_	_
12	alterations	alteration	NNS	NNS	_	3	ccomp	_	_
13	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	present	present	JJ	JJ	_	5	amod	_	_
4	in-vitro	in-vitro	FW	FW	_	5	amod	_	_
5	experiments	experiment	NNS	NNS	_	33	nmod	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	33	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	of	of	IN	IN	_	13	case	_	_
12	further	further	JJ	JJ	_	13	amod	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	9	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
19	receptor	receptor	NN	NN	_	21	compound	_	_
20	antagonist	antagonist	NN	NN	_	21	compound	_	_
21	RU	ru	NN	NN	_	9	conj	_	_
22	486	486	CD	CD	_	21	nummod	_	_
23	,	,	,	,	_	7	punct	_	_
24	on	on	IN	IN	_	26	case	_	_
25	structural	structural	JJ	JJ	_	26	amod	_	_
26	order	order	NN	NN	_	7	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	human	human	JJ	JJ	_	31	amod	_	_
29	erythrocyte	erythrocyte	NN	NN	_	31	compound	_	_
30	ghost	ghost	NN	NN	_	31	compound	_	_
31	membranes	membrane	NNS	NNS	_	26	nmod	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	investigated	investigate	VBN	VBN	_	0	root	_	_
34	by	by	IN	IN	_	35	mark	_	_
35	determining	determine	VBG	VBG	_	33	advcl	_	_
36	the	the	DT	DT	_	39	det	_	_
37	steady-state	steady-state	JJ	JJ	_	39	amod	_	_
38	fluorescence	fluorescence	NN	NN	_	39	compound	_	_
39	anisotropy	anisotropy	NN	NN	_	35	dobj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	diphenylhexatriene	diphenylhexatriene	NN	NN	_	39	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	DPH	dph	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	.	.	.	.	_	33	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	induce	induce	VB	VB	_	3	xcomp	_	_
6	a	a	DT	DT	_	8	det	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	decrease	decrease	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	membrane	membrane	NN	NN	_	12	compound	_	_
11	structural	structural	JJ	JJ	_	12	amod	_	_
12	order	order	NN	NN	_	8	nmod	_	_
13	at	at	IN	IN	_	14	case	_	_
14	concentrations	concentration	NNS	NNS	_	5	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	about	about	RB	RB	_	17	advmod	_	_
17	10(-6)	10(-6)	CD	CD	_	18	nummod	_	_
18	M	m	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	concentration-dependent	concentration-dependent	JJ	JJ	_	22	amod	_	_
22	manner	manner	NN	NN	_	5	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	correlation	correlation	NN	NN	_	2	dobj	_	_
5	between	between	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	uptake	uptake	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	ghost	ghost	NN	NN	_	13	compound	_	_
13	membranes	membrane	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	decrease	decrease	NN	NN	_	7	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	structural	structural	JJ	JJ	_	20	amod	_	_
20	order	order	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	12	nsubj	_	_
4	tested	test	VBN	VBN	_	3	acl	_	_
5	,	,	,	,	_	3	punct	_	_
6	methylprednisolone	methylprednisolone	NN	NN	_	3	appos	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	corticosterone	corticosterone	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	3	punct	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	effective	effective	JJ	JJ	_	0	root	_	_
13	at	at	IN	IN	_	14	case	_	_
14	concentrations	concentration	NNS	NNS	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	10(-5)	10(-5)	CD	CD	_	17	nummod	_	_
17	M	m	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	19	cc	_	_
19	greater	greater	JJR	JJR	_	17	nummod	_	_
20	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	change	change	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	membrane	membrane	NN	NN	_	8	compound	_	_
7	structural	structural	JJ	JJ	_	8	amod	_	_
8	order	order	NN	NN	_	4	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	RU	ru	NN	NN	_	4	nmod	_	_
11	486	486	CD	CD	_	10	nummod	_	_
12	up	up	IN	IN	_	15	case	_	_
13	to	to	TO	TO	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	concentration	concentration	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	10(-4)	10(-4)	CD	CD	_	18	nummod	_	_
18	M	m	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	simultaneous	simultaneous	JJ	JJ	_	4	amod	_	_
4	incubation	incubation	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	RU	ru	NN	NN	_	4	nmod	_	_
7	486	486	CD	CD	_	6	nummod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	4	nmod	_	_
10	caused	cause	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	distinct	distinct	JJ	JJ	_	13	amod	_	_
13	interference	interference	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	RU	ru	NN	NN	_	13	nmod	_	_
16	486	486	CD	CD	_	15	nummod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	dexamethasone	dexamethasone	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	26	advmod	_	_
2	,	,	,	,	_	26	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	6	amod	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	perturbation	perturbation	NN	NN	_	26	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	possibility	possibility	NN	NN	_	6	conj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	inhibit	inhibit	VB	VB	_	9	acl	_	_
12	it	it	PRP	PRP	_	11	dobj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	RU	ru	NN	NN	_	11	nmod	_	_
15	486	486	CD	CD	_	14	nummod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	inactivity	inactivity	NN	NN	_	6	conj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	structurally	structurally	RB	RB	_	23	advmod	_	_
23	related	related	JJ	JJ	_	24	amod	_	_
24	progesterone	progesterone	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	6	punct	_	_
26	refer	refer	VBP	VBP	_	0	root	_	_
27	to	to	TO	TO	_	31	case	_	_
28	relatively	relatively	RB	RB	_	29	advmod	_	_
29	specific	specific	JJ	JJ	_	31	amod	_	_
30	binding	bind	VBG	VBG	_	31	amod	_	_
31	sites	site	NNS	NNS	_	26	nmod	_	_
32	for	for	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	glucocorticoids	glucocorticoid	NNS	NNS	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	membrane	membrane	NN	NN	_	31	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	erythrocyte	erythrocyte	NN	NN	_	40	compound	_	_
40	ghosts	ghost	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	26	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	genomic	genomic	JJ	JJ	_	4	amod	_	_
4	configuration	configuration	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	GM-CSF	gm-csf	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	IL-3	il-3	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	M-CSF	m-csf	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	6	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	C-FMS	c-fms	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	6	punct	_	_
16	early	early	JJ	JJ	_	19	amod	_	_
17	growth	growth	NN	NN	_	19	compound	_	_
18	response	response	NN	NN	_	19	compound	_	_
19	gene-1	gene-1	NN	NN	_	6	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	EGR-1	egr-1	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	6	cc	_	_
24	M-CSF	m-csf	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	6	conj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	primary	primary	JJ	JJ	_	29	amod	_	_
28	myelodysplastic	myelodysplastic	JJ	JJ	_	29	amod	_	_
29	syndromes	syndrome	NNS	NNS	_	1	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	19	nsubjpass	_	_
5	from	from	IN	IN	_	7	case	_	_
6	seventeen	seventeen	CD	CD	_	7	nummod	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	myelodysplastic	myelodysplastic	JJ	JJ	_	11	amod	_	_
11	syndromes	syndrome	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	MDS	mds	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	advanced	advanced	JJ	JJ	_	17	amod	_	_
17	stage	stage	NN	NN	_	11	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	enriched	enriched	JJ	JJ	_	0	root	_	_
20	for	for	IN	IN	_	21	case	_	_
21	blasts	blast	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	tested	test	VBN	VBN	_	19	conj	_	_
24	for	for	IN	IN	_	28	case	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	1	1	LS	LS	_	28	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	karyotype	karyotype	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	2	2	LS	LS	_	34	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	genomic	genomic	JJ	JJ	_	34	amod	_	_
34	configuration	configuration	NN	NN	_	28	conj	_	_
35	and	and	CC	CC	_	28	cc	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	3	3	LS	LS	_	39	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	expression	expression	NN	NN	_	28	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	IL-3	il-3	NN	NN	_	28	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	GM-CSF	gm-csf	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	41	punct	_	_
45	FMS	fms	NN	NN	_	41	conj	_	_
46	and	and	CC	CC	_	41	cc	_	_
47	EGR-1	egr-1	NN	NN	_	41	conj	_	_
48	genes	gene	NNS	NNS	_	41	dep	_	_
49	which	which	WDT	WDT	_	52	nsubj	_	_
50	are	be	VBP	VBP	_	52	cop	_	_
51	all	all	DT	DT	_	52	advmod	_	_
52	located	located	JJ	JJ	_	41	acl:relcl	_	_
53	on	on	IN	IN	_	58	case	_	_
54	the	the	DT	DT	_	58	det	_	_
55	long	long	JJ	JJ	_	58	amod	_	_
56	arm	arm	NN	NN	_	58	compound	_	_
57	of	of	IN	IN	_	58	amod	_	_
58	chromosome	chromosome	NN	NN	_	52	nmod	_	_
59	5	5	CD	CD	_	58	nummod	_	_
60	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	26	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	M-CSF	m-csf	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	that	that	WDT	WDT	_	12	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	12	aux	_	_
10	been	be	VBN	VBN	_	12	auxpass	_	_
11	recently	recently	RB	RB	_	12	advmod	_	_
12	reassigned	reassign	VBN	VBN	_	6	acl:relcl	_	_
13	to	to	TO	TO	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	short	short	JJ	JJ	_	18	amod	_	_
16	arm	arm	NN	NN	_	18	compound	_	_
17	of	of	IN	IN	_	18	amod	_	_
18	chromosome	chromosome	NN	NN	_	12	nmod	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	lp	lp	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	2	punct	_	_
24	was	be	VBD	VBD	_	26	auxpass	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	investigated	investigate	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Aims	aim	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	1	nmod	_	_
5	were	be	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	10	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	assess	assess	VB	VB	_	5	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	potential	potential	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	maintenance	maintenance	NN	NN	_	16	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	expansion	expansion	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	neoplastic	neoplastic	JJ	JJ	_	28	amod	_	_
28	clones	clone	NNS	NNS	_	22	nmod	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	2	2	LS	LS	_	33	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	search	search	VB	VB	_	10	conj	_	_
34	for	for	IN	IN	_	36	case	_	_
35	constitutional	constitutional	JJ	JJ	_	36	amod	_	_
36	losses	loss	NNS	NNS	_	33	nmod	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	rearrangements	rearrangement	NNS	NNS	_	36	conj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	one	one	CD	CD	_	41	nummod	_	_
41	allele	allele	NN	NN	_	36	nmod	_	_
42	followed	follow	VBN	VBN	_	36	acl	_	_
43	by	by	IN	IN	_	45	case	_	_
44	a	a	DT	DT	_	45	det	_	_
45	deletion	deletion	NN	NN	_	42	nmod	_	_
46	of	of	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	second	second	JJ	JJ	_	49	amod	_	_
49	allele	allele	NN	NN	_	45	nmod	_	_
50	of	of	IN	IN	_	53	case	_	_
51	the	the	DT	DT	_	53	det	_	_
52	same	same	JJ	JJ	_	53	amod	_	_
53	genes	gene	NNS	NNS	_	49	nmod	_	_
54	in	in	IN	IN	_	57	case	_	_
55	the	the	DT	DT	_	57	det	_	_
56	leukemic	leukemic	JJ	JJ	_	57	amod	_	_
57	cells	cell	NNS	NNS	_	53	nmod	_	_
58	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	issue	issue	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	investigated	investigate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	comparing	compare	VBG	VBG	_	5	advcl	_	_
8	,	,	,	,	_	7	punct	_	_
9	in	in	IN	IN	_	11	case	_	_
10	8	8	CD	CD	_	11	nummod	_	_
11	cases	case	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	constitutive	constitutive	JJ	JJ	_	14	amod	_	_
14	DNA	dna	NN	NN	_	7	dobj	_	_
15	from	from	IN	IN	_	17	case	_	_
16	skin	skin	NN	NN	_	17	compound	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	leukemic	leukemic	JJ	JJ	_	20	amod	_	_
20	DNA	dna	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Eleven	eleven	CD	CD	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	17	17	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	1	nmod	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	abnormal	abnormal	JJ	JJ	_	8	amod	_	_
8	karyotypes	karyotype	NNS	NNS	_	6	dobj	_	_
9	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	M-CSF	m-csf	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	6	6	CD	CD	_	8	nummod	_	_
8	cases	case	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	FMS	fms	NN	NN	_	17	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	EGR-1	egr-1	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	11	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	5	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	2	2	CD	CD	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	latter	latter	JJ	JJ	_	23	amod	_	_
23	cases	case	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	autocrine	autocrine	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	growth	growth	NN	NN	_	3	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
9	only	only	RB	RB	_	8	advmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	2	2	CD	CD	_	13	nummod	_	_
13	patients	patient	NNS	NNS	_	8	nmod	_	_
14	whose	whose	WP$	WP$	_	15	nmod:poss	_	_
15	cells	cell	NNS	NNS	_	16	nsubj	_	_
16	expressed	express	VBD	VBD	_	13	acl:relcl	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	M-CSF	m-csf	NN	NN	_	16	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	FMS	fms	NN	NN	_	19	conj	_	_
22	genes	gene	NNS	NNS	_	19	dep	_	_
23	.	.	.	.	_	8	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	germline	germline	NN	NN	_	7	nsubjpass	_	_
3	changes	change	NNS	NNS	_	2	dep	_	_
4	or	or	CC	CC	_	2	cc	_	_
5	rearrangements	rearrangement	NNS	NNS	_	2	conj	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	any	any	DT	DT	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	studied	study	VBN	VBN	_	12	acl	_	_
14	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	deregulation	deregulation	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	genes	gene	NNS	NNS	_	3	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	for	for	IN	IN	_	11	case	_	_
8	certain	certain	JJ	JJ	_	11	amod	_	_
9	hemopoietic	hemopoietic	JJ	JJ	_	11	amod	_	_
10	growth	growth	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	6	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	receptors	receptor	NNS	NNS	_	11	conj	_	_
14	does	do	VBZ	VBZ	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	seem	seem	VB	VB	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	represent	represent	VB	VB	_	16	xcomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	major	major	JJ	JJ	_	21	amod	_	_
21	mechanism	mechanism	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	MDS	mds	NN	NN	_	24	compound	_	_
24	progression	progression	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	leukemic	leukemic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	caused	cause	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	repressive	repressive	JJ	JJ	_	12	amod	_	_
12	function	function	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Induction	induction	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	account	account	VB	VB	_	1	acl:relcl	_	_
10	for	for	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	therapeutic	therapeutic	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	various	various	JJ	JJ	_	18	amod	_	_
18	diseases	disease	NNS	NNS	_	13	nmod	_	_
19	including	include	VBG	VBG	_	20	case	_	_
20	leukemia	leukemia	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	1	punct	_	_
22	depends	depend	VBZ	VBZ	_	0	root	_	_
23	on	on	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	glucocorticoid	glucocorticoid	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	22	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	15	nsubjpass	_	_
5	leading	lead	VBG	VBG	_	4	acl	_	_
6	from	from	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	activated	activate	VBN	VBN	_	9	amod	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lysis	lysis	NN	NN	_	5	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	understood	understand	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	prevailing	prevail	VBG	VBG	_	3	amod	_	_
3	hypothesis	hypothesis	NN	NN	_	4	nsubj	_	_
4	postulates	postulate	VBZ	VBZ	_	0	root	_	_
5	induction	induction	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	so-called	so-called	JJ	JJ	_	10	amod	_	_
8	'	'	``	``	_	10	punct	_	_
9	lysis	lysis	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	5	nmod	_	_
11	'	'	''	''	_	10	punct	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	activated	activate	VBN	VBN	_	15	amod	_	_
15	receptor	receptor	NN	NN	_	5	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	an	a	DT	DT	_	12	det	_	_
9	activation-deficient	activation-deficient	JJ	JJ	_	12	amod	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	mutant	mutant	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	as	as	RB	RB	_	15	advmod	_	_
15	effective	effective	JJ	JJ	_	6	ccomp	_	_
16	as	as	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	wild-type	wild-type	JJ	JJ	_	19	amod	_	_
19	receptor	receptor	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	repression	repression	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	AP-1	ap-1	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	inhibition	inhibition	NN	NN	_	21	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	interleukin-2	interleukin-2	NN	NN	_	29	compound	_	_
29	production	production	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	21	punct	_	_
31	inhibition	inhibition	NN	NN	_	21	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	c-myc	c-myc	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	21	cc	_	_
36	induction	induction	NN	NN	_	21	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	apoptosis	apoptosis	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	10	nsubj	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	induce	induce	VB	VB	_	4	ccomp	_	_
11	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	through	through	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	retinoic	retinoic	JJ	JJ	_	19	amod	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	10	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	whose	whose	WP$	WP$	_	23	nmod:poss	_	_
22	repressive	repressive	JJ	JJ	_	23	amod	_	_
23	functions	function	NNS	NNS	_	31	nsubj	_	_
24	but	but	CC	CC	_	25	cc	_	_
25	not	not	RB	RB	_	23	cc	_	_
26	target	target	NN	NN	_	28	compound	_	_
27	site	site	NN	NN	_	28	compound	_	_
28	specificity	specificity	NN	NN	_	23	conj	_	_
29	,	,	,	,	_	31	punct	_	_
30	are	be	VBP	VBP	_	31	cop	_	_
31	similar	similar	JJ	JJ	_	19	acl:relcl	_	_
32	to	to	TO	TO	_	33	case	_	_
33	those	those	DT	DT	_	31	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	glucocorticoid	glucocorticoid	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	primary	primary	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	receptor	receptor	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
12	correlates	correlate	VBZ	VBZ	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	repression	repression	NN	NN	_	12	nmod	_	_
16	rather	rather	RB	RB	_	15	cc	_	_
17	than	than	IN	IN	_	16	mwe	_	_
18	activation	activation	NN	NN	_	15	conj	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	could	could	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	mediated	mediate	VBN	VBN	_	12	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	interference	interference	NN	NN	_	22	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	other	other	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	24	nmod	_	_
29	required	require	VBN	VBN	_	28	acl	_	_
30	for	for	IN	IN	_	32	case	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	survival	survival	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	Runt	runt	NN	NN	_	8	compound	_	_
5	domain-encoding	domain-encoding	JJ	JJ	_	8	amod	_	_
6	PEBP2	pebp2	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	1	nmod	_	_
12	during	during	IN	IN	_	14	case	_	_
13	thymic	thymic	JJ	JJ	_	14	amod	_	_
14	development	development	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	dep	_	_
2	PEBP2	pebp2	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	PEBP2	pebp2	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	4	conj	_	_
9	genes	gene	NNS	NNS	_	4	dep	_	_
10	encode	encode	VBP	VBP	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	subunit	subunit	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	murine	murine	NN	NN	_	18	compound	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	PEBP2	pebp2	NN	NN	_	13	appos	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	implicated	implicate	VBN	VBN	_	20	acl:relcl	_	_
25	as	as	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	T-cell-specific	t-cell-specific	JJ	JJ	_	29	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	regulator	regulator	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	related	related	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	5	nsubj	_	_
5	share	share	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	evolutionarily	evolutionarily	RB	RB	_	8	advmod	_	_
8	conserved	conserve	VBN	VBN	_	9	amod	_	_
9	region	region	NN	NN	_	5	dobj	_	_
10	encoding	encode	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Runt	runt	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	PEBP2	pebp2	NN	NN	_	3	compound	_	_
2	alpha	alpha	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	the	the	DT	DT	_	7	det	_	_
6	murine	murine	NN	NN	_	7	compound	_	_
7	counterpart	counterpart	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	AML1	aml1	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	located	located	JJ	JJ	_	10	acl:relcl	_	_
15	at	at	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	breakpoints	breakpoint	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	8;21	8;21	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	3;21	3;21	NN	NN	_	20	conj	_	_
23	chromosome	chromosome	NN	NN	_	24	compound	_	_
24	translocations	translocation	NNS	NNS	_	20	dep	_	_
25	associated	associate	VBN	VBN	_	20	acl	_	_
26	with	with	IN	IN	_	29	case	_	_
27	acute	acute	JJ	JJ	_	29	amod	_	_
28	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
29	leukemia	leukemia	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Northern	northern	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	RNA	rna	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	blots	blot	NNS	NNS	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	various	various	JJ	JJ	_	10	amod	_	_
8	adult	adult	JJ	JJ	_	10	amod	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	tissues	tissue	NNS	NNS	_	5	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	22	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	levels	level	NNS	NNS	_	22	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	expression	expression	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	both	both	DT	DT	_	19	det	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	were	be	VBD	VBD	_	22	cop	_	_
21	most	most	RBS	RBS	_	22	advmod	_	_
22	prominent	prominent	JJ	JJ	_	11	ccomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	thymus	thymus	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	transcripts	transcript	NNS	NNS	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	PEBP2	pebp2	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	A	a	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	mouse	mouse	NN	NN	_	12	compound	_	_
10	AML1/PEBP2	aml1/pebp2	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	7	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	thymuses	thymus	NNS	NNS	_	17	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	day	day	NN	NN	_	24	compound	_	_
23	16	16	CD	CD	_	24	nummod	_	_
24	embryos	embryo	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	newborns	newborn	NNS	NNS	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	as	as	RB	RB	_	24	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	4-week-old	4-week-old	JJ	JJ	_	33	amod	_	_
32	adult	adult	JJ	JJ	_	31	dep	_	_
33	mice	mouse	NNS	NNS	_	24	conj	_	_
34	,	,	,	,	_	14	punct	_	_
35	by	by	IN	IN	_	38	case	_	_
36	in	in	FW	FW	_	38	amod	_	_
37	situ	situ	FW	FW	_	36	dep	_	_
38	hybridization	hybridization	NN	NN	_	14	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	persisted	persist	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	lymph	lymph	NN	NN	_	10	compound	_	_
10	nodes	node	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	adult	adult	JJ	JJ	_	13	amod	_	_
13	mice	mouse	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	transcripts	transcript	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	all	all	PDT	PDT	_	9	dep	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	CD4-	cd4-	JJ	JJ	_	9	amod	_	_
9	CD8-	cd8-	JJ	JJ	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
12	CD8+	cd8+	JJ	JJ	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	CD4+	cd4+	JJ	JJ	_	15	amod	_	_
15	CD8-	cd8-	JJ	JJ	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	CD4-	cd4-	JJ	JJ	_	19	amod	_	_
19	CD8+	cd8+	JJ	JJ	_	9	conj	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	populations	population	NNS	NNS	_	9	dep	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	both	both	DT	DT	_	6	det	_	_
6	genes	gene	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	throughout	throughout	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	development	development	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	supporting	support	VBG	VBG	_	3	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	notion	notion	NN	NN	_	16	dobj	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	PEBP2	pebp2	NN	NN	_	25	nsubj	_	_
21	is	be	VBZ	VBZ	_	25	cop	_	_
22	a	a	DT	DT	_	25	det	_	_
23	T-cell-specific	t-cell-specific	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	18	ccomp	_	_
26	.	.	.	.	_	3	punct	_	_

1	Transcripts	transcript	NNS	NNS	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	mouse	mouse	NN	NN	_	6	compound	_	_
4	AML1/PEBP2	aml1/pebp2	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	day	day	NN	NN	_	15	compound	_	_
12	12	12	CD	CD	_	15	nummod	_	_
13	fetal	fetal	JJ	JJ	_	15	amod	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	13	dep	_	_
15	liver	liver	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	bone	bone	NN	NN	_	21	compound	_	_
20	marrow	marrow	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	newborn	newborn	JJ	JJ	_	24	amod	_	_
24	mice	mouse	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	implication	implication	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	mouse	mouse	NN	NN	_	8	compound	_	_
5	AML1/PEBP2	aml1/pebp2	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	other	other	JJ	JJ	_	11	amod	_	_
13	than	than	IN	IN	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	lineage	lineage	NN	NN	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	discussed	discuss	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	21	case	_	_
21	relation	relation	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	leukemogenesis	leukemogenesis	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	cell-type-specific	cell-type-specific	JJ	JJ	_	8	amod	_	_
4	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	alpha-chain	alpha-chain	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	:	:	:	:	_	1	punct	_	_
10	potential	potential	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	1	dep	_	_
12	of	of	IN	IN	_	14	case	_	_
13	physical	physical	JJ	JJ	_	14	amod	_	_
14	interactions	interaction	NNS	NNS	_	11	nmod	_	_
15	between	between	IN	IN	_	16	case	_	_
16	Elf-1	elf-1	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	HMG-I(Y)	hmg-i(y)	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
22	B	b	NN	NN	_	24	compound	_	_
23	family	family	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	16	conj	_	_
25	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	interleukin	interleukin	NN	NN	_	10	compound	_	_
3	2	2	CD	CD	_	10	nummod	_	_
4	receptor	receptor	NN	NN	_	10	compound	_	_
5	alpha-chain	alpha-chain	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	IL-2R	il-2r	NN	NN	_	10	compound	_	_
8	alpha	alpha	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	gene	gene	NN	NN	_	15	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	15	auxpass	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	and	and	CC	CC	_	15	advmod	_	_
14	potently	potently	RB	RB	_	13	advmod	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	15	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	mitogenic	mitogenic	JJ	JJ	_	23	amod	_	_
23	stimuli	stimulus	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Previously	previously	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	enhancer	enhancer	NN	NN	_	19	nsubjpass	_	_
6	between	between	IN	IN	_	7	case	_	_
7	nucleotides	nucleotide	NNS	NNS	_	5	nmod	_	_
8	-299	-299	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	-228	-228	CD	CD	_	7	conj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	contains	contain	VBZ	VBZ	_	5	acl:relcl	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	CArG	carg	NN	NN	_	14	conj	_	_
17	motifs	motif	NNS	NNS	_	14	dep	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	identified	identify	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	characterization	characterization	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	second	second	JJ	JJ	_	12	amod	_	_
9	essential	essential	JJ	JJ	_	12	amod	_	_
10	positive	positive	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	5	nmod	_	_
13	located	located	JJ	JJ	_	12	amod	_	_
14	between	between	IN	IN	_	15	case	_	_
15	nucleotides	nucleotide	NNS	NNS	_	13	nmod	_	_
16	-137	-137	CD	CD	_	15	nummod	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	-64	-64	CD	CD	_	15	conj	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	binds	bind	VBZ	VBZ	_	12	acl:relcl	_	_
21	Elf-1	elf-1	NN	NN	_	20	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	HMG-I(Y)	hmg-i(y)	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	maximal	maximal	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	paralleling	parallel	VBG	VBG	_	3	advcl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	type	type	NN	NN	_	14	compound	_	_
14	specificity	specificity	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Elf-1	elf-1	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Transcription	transcription	NN	NN	_	8	nsubjpass	_	_
2	from	from	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	IL-2R	il-2r	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	19	advmod	_	_
10	either	either	CC	CC	_	12	cc:preconj	_	_
11	the	the	DT	DT	_	12	det	_	_
12	Elf-1	elf-1	NN	NN	_	19	nsubjpass	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	HMG-I(Y)	hmg-i(y)	NN	NN	_	12	conj	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	12	dep	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	mutated	mutate	VBN	VBN	_	8	advcl	_	_
20	.	.	.	.	_	8	punct	_	_

1	Coexpression	coexpression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	both	both	DT	DT	_	4	det	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	activated	activate	VBD	VBD	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	-137	-137	CD	CD	_	12	nummod	_	_
10	to	to	TO	TO	_	12	dep	_	_
11	-64	-64	CD	CD	_	12	nummod	_	_
12	element	element	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	COS-7	cos-7	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Elf-1	elf-1	NN	NN	_	3	nsubj	_	_
2	physically	physically	RB	RB	_	3	advmod	_	_
3	associated	associate	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	HMG-I	hmg-i	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	with	with	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	5	conj	_	_
10	p50	p50	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	c-Rel	c-rel	NN	NN	_	9	conj	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	3	advmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	suggesting	suggest	VBG	VBG	_	3	xcomp	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	protein-protein	protein-protein	JJ	JJ	_	19	amod	_	_
19	interactions	interaction	NNS	NNS	_	22	nsubj	_	_
20	might	might	MD	MD	_	22	aux	_	_
21	functionally	functionally	RB	RB	_	22	advmod	_	_
22	coordinate	coordinate	VB	VB	_	16	ccomp	_	_
23	the	the	DT	DT	_	24	det	_	_
24	actions	action	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	upstream	upstream	JJ	JJ	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	downstream	downstream	JJ	JJ	_	27	conj	_	_
30	positive	positive	JJ	JJ	_	32	amod	_	_
31	regulatory	regulatory	JJ	JJ	_	32	amod	_	_
32	elements	element	NNS	NNS	_	27	dep	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	report	report	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	physical	physical	JJ	JJ	_	9	amod	_	_
9	interaction	interaction	NN	NN	_	5	nmod	_	_
10	between	between	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	Ets	ets	NN	NN	_	14	compound	_	_
13	family	family	NN	NN	_	14	compound	_	_
14	member	member	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	family	family	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	14	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	new	new	JJ	JJ	_	4	dep	_	_
6	insights	insight	NNS	NNS	_	3	dobj	_	_
7	into	into	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	protein-protein	protein-protein	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	protein-DNA	protein-dna	JJ	JJ	_	9	conj	_	_
12	interactions	interaction	NNS	NNS	_	9	dep	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	regulate	regulate	VBP	VBP	_	6	acl:relcl	_	_
15	cell-type-specific	cell-type-specific	JJ	JJ	_	21	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	inducible	inducible	JJ	JJ	_	15	conj	_	_
18	IL-2R	il-2r	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	14	dobj	_	_
22	and	and	CC	CC	_	3	cc	_	_
23	also	also	RB	RB	_	24	advmod	_	_
24	have	have	VBP	VBP	_	3	conj	_	_
25	implications	implication	NNS	NNS	_	24	dobj	_	_
26	for	for	IN	IN	_	28	case	_	_
27	other	other	JJ	JJ	_	28	amod	_	_
28	genes	gene	NNS	NNS	_	25	nmod	_	_
29	regulated	regulate	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	31	case	_	_
31	Elf-1	elf-1	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	family	family	NN	NN	_	36	compound	_	_
36	proteins	protein	NNS	NNS	_	31	conj	_	_
37	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	on	on	IN	IN	_	7	case	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	2	nsubj	_	_
2	have	have	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	dobj	_	_
6	on	on	IN	IN	_	7	case	_	_
7	inflammatory	inflammatory	JJ	JJ	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immune	immune	JJ	JJ	_	7	conj	_	_
10	responses	response	NNS	NNS	_	7	dep	_	_
11	,	,	,	,	_	2	punct	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	this	this	DT	DT	_	18	nsubj	_	_
14	may	may	MD	MD	_	18	aux	_	_
15	be	be	VB	VB	_	18	cop	_	_
16	through	through	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	modulation	modulation	NN	NN	_	2	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	18	nmod	_	_
22	binding	bind	VBG	VBG	_	21	acl	_	_
23	to	to	TO	TO	_	24	case	_	_
24	DNA	dna	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	41	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	activator	activator	NN	NN	_	9	compound	_	_
9	protein-1	protein-1	NN	NN	_	6	appos	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AP-1	ap-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
15	factor	factor	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	9	conj	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	NF	nf	NN	NN	_	21	compound	_	_
20	kappa	kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	9	punct	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	cAMP-responsive	camp-responsive	JJ	JJ	_	28	amod	_	_
26	element	element	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	9	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CREB	creb	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	with	with	IN	IN	_	33	case	_	_
33	DNA	dna	NN	NN	_	2	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	glucocorticoid	glucocorticoid	NN	NN	_	36	compound	_	_
36	receptors	receptor	NNS	NNS	_	33	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	GR	gr	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	was	be	VBD	VBD	_	41	auxpass	_	_
41	analyzed	analyze	VBN	VBN	_	0	root	_	_
42	in	in	IN	IN	_	47	case	_	_
43	human	human	JJ	JJ	_	47	amod	_	_
44	peripheral	peripheral	JJ	JJ	_	47	amod	_	_
45	blood	blood	NN	NN	_	47	compound	_	_
46	mononuclear	mononuclear	JJ	JJ	_	47	amod	_	_
47	cells	cell	NNS	NNS	_	41	nmod	_	_
48	by	by	IN	IN	_	52	case	_	_
49	gel	gel	NN	NN	_	52	compound	_	_
50	mobility	mobility	NN	NN	_	52	compound	_	_
51	shift	shift	NN	NN	_	52	compound	_	_
52	assays	assay	NNS	NNS	_	41	nmod	_	_
53	.	.	.	.	_	41	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	12	compound	_	_
2	,	,	,	,	_	1	punct	_	_
3	IL-1	il-1	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	1	conj	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	phorbol	phorbol	NN	NN	_	8	compound	_	_
7	myristate	myristate	NN	NN	_	8	compound	_	_
8	acetate	acetate	NN	NN	_	1	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PMA	pma	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	treatment	treatment	NN	NN	_	13	nsubj	_	_
13	increased	increase	VBD	VBD	_	0	root	_	_
14	AP-1	ap-1	NN	NN	_	20	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NF	nf	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	14	conj	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	13	dobj	_	_
21	by	by	IN	IN	_	25	case	_	_
22	up	up	RB	RB	_	24	advmod	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	200	200	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	13	nmod	_	_
26	but	but	CC	CC	_	13	cc	_	_
27	decreased	decrease	VBD	VBD	_	13	conj	_	_
28	CREB	creb	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	27	dobj	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	38	38	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	27	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	over	over	IN	IN	_	38	case	_	_
35	a	a	DT	DT	_	38	det	_	_
36	60-min	60-min	JJ	JJ	_	38	amod	_	_
37	time	time	NN	NN	_	38	compound	_	_
38	course	course	NN	NN	_	27	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	produced	produce	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	rapid	rapid	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	sustained	sustained	JJ	JJ	_	4	conj	_	_
7	increase	increase	NN	NN	_	2	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	a	a	DT	DT	_	18	det	_	_
15	concomitant	concomitant	JJ	JJ	_	18	amod	_	_
16	40-50	40-50	CD	CD	_	17	dep	_	_
17	%	%	NN	NN	_	18	dep	_	_
18	decrease	decrease	NN	NN	_	7	conj	_	_
19	in	in	IN	IN	_	29	case	_	_
20	AP-1	ap-1	NN	NN	_	29	compound	_	_
21	,	,	,	,	_	20	punct	_	_
22	NF	nf	NN	NN	_	24	compound	_	_
23	kappa	kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	CREB	creb	NN	NN	_	20	conj	_	_
28	DNA	dna	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	18	nmod	_	_
30	that	that	WDT	WDT	_	32	nsubjpass	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	blocked	block	VBN	VBN	_	18	acl:relcl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	combined	combined	JJ	JJ	_	35	amod	_	_
35	dexamethasone	dexamethasone	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	cytokine	cytokine	NN	NN	_	35	conj	_	_
38	or	or	CC	CC	_	35	cc	_	_
39	PMA	pma	NN	NN	_	35	conj	_	_
40	treatment	treatment	NN	NN	_	35	dep	_	_
41	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	due	due	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	increases	increase	NNS	NNS	_	5	advcl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	localization	localization	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	GR	gr	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	to	to	TO	TO	_	18	case	_	_
17	reduced	reduce	VBN	VBN	_	18	amod	_	_
18	amounts	amount	NNS	NNS	_	7	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	other	other	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	cells	cell	NNS	NNS	_	11	nmod	_	_
7	GR	gr	NN	NN	_	11	nsubj	_	_
8	within	within	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	7	nmod	_	_
11	interacts	interact	VBZ	VBZ	_	2	ccomp	_	_
12	with	with	IN	IN	_	15	case	_	_
13	cytokine-stimulated	cytokine-stimulated	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	process	process	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cross	cross	JJ	JJ	_	21	amod	_	_
21	coupling	coupling	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	7	nsubj	_	_
2	may	may	MD	MD	_	7	aux	_	_
3	be	be	VB	VB	_	7	cop	_	_
4	an	a	DT	DT	_	7	det	_	_
5	important	important	JJ	JJ	_	7	amod	_	_
6	molecular	molecular	JJ	JJ	_	5	dep	_	_
7	site	site	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	10	case	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	action	action	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cDNA	cdna	NN	NN	_	4	compound	_	_
4	clones	clone	NNS	NNS	_	1	nmod	_	_
5	for	for	IN	IN	_	11	case	_	_
6	42	42	CD	CD	_	11	nummod	_	_
7	different	different	JJ	JJ	_	11	amod	_	_
8	Kruppel-related	kruppel-related	JJ	JJ	_	11	amod	_	_
9	zinc	zinc	NN	NN	_	11	compound	_	_
10	finger	finger	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	4	nmod	_	_
12	expressed	express	VBN	VBN	_	4	acl	_	_
13	in	in	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	monoblast	monoblast	NN	NN	_	19	compound	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	line	line	NN	NN	_	19	compound	_	_
19	U-937	u-937	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	complexity	complexity	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	structural	structural	JJ	JJ	_	7	amod	_	_
7	characteristics	characteristic	NNS	NNS	_	4	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	zinc	zinc	NN	NN	_	11	compound	_	_
10	finger	finger	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	4	nmod	_	_
12	expressed	express	VBN	VBN	_	11	acl	_	_
13	during	during	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	hematopoiesis	hematopoiesis	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	isolate	isolate	VB	VB	_	2	conj	_	_
19	novel	novel	JJ	JJ	_	20	amod	_	_
20	regulators	regulator	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	blood	blood	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	2	punct	_	_
26	a	a	DT	DT	_	29	det	_	_
27	degenerate	degenerate	JJ	JJ	_	29	amod	_	_
28	oligonucleotide	oligonucleotide	NN	NN	_	29	compound	_	_
29	probe	probe	NN	NN	_	39	nsubjpass	_	_
30	specific	specific	JJ	JJ	_	29	amod	_	_
31	for	for	IN	IN	_	37	case	_	_
32	a	a	DT	DT	_	37	det	_	_
33	consensus	consensus	NN	NN	_	37	compound	_	_
34	zinc	zinc	NN	NN	_	37	compound	_	_
35	finger	finger	NN	NN	_	37	compound	_	_
36	peptide	peptide	NN	NN	_	37	compound	_	_
37	domain	domain	NN	NN	_	30	nmod	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	used	use	VBN	VBN	_	2	parataxis	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	isolate	isolate	VB	VB	_	39	xcomp	_	_
42	63	63	CD	CD	_	44	nummod	_	_
43	cDNA	cdna	NN	NN	_	44	compound	_	_
44	clones	clone	NNS	NNS	_	41	dobj	_	_
45	for	for	IN	IN	_	49	case	_	_
46	Kruppel-related	kruppel-related	JJ	JJ	_	49	amod	_	_
47	zinc	zinc	NN	NN	_	49	compound	_	_
48	finger	finger	NN	NN	_	49	compound	_	_
49	genes	gene	NNS	NNS	_	44	nmod	_	_
50	from	from	IN	IN	_	56	case	_	_
51	the	the	DT	DT	_	56	det	_	_
52	human	human	JJ	JJ	_	56	amod	_	_
53	monoblast	monoblast	NN	NN	_	56	compound	_	_
54	cell	cell	NN	NN	_	56	compound	_	_
55	line	line	NN	NN	_	56	compound	_	_
56	U-937	u-937	NN	NN	_	41	nmod	_	_
57	.	.	.	.	_	2	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	extensive	extensive	JJ	JJ	_	4	amod	_	_
3	nucleotide	nucleotide	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	14	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Northern	northern	NN	NN	_	7	compound	_	_
7	blot	blot	NN	NN	_	4	conj	_	_
8	analysis	analysis	NN	NN	_	4	dep	_	_
9	,	,	,	,	_	14	punct	_	_
10	these	these	DT	DT	_	12	det	_	_
11	cDNA	cdna	NN	NN	_	12	compound	_	_
12	clones	clone	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	originate	originate	VB	VB	_	14	xcomp	_	_
17	from	from	IN	IN	_	21	case	_	_
18	approximately	approximately	RB	RB	_	19	advmod	_	_
19	42	42	CD	CD	_	21	nummod	_	_
20	different	different	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	HZF	hzf	NN	NN	_	21	appos	_	_
24	1-42	1-42	CD	CD	_	23	nummod	_	_
25	)	)	-RRB-	-RRB-	_	23	punct	_	_
26	of	of	IN	IN	_	27	case	_	_
27	which	which	WDT	WDT	_	33	nmod	_	_
28	only	only	RB	RB	_	29	advmod	_	_
29	8	8	CD	CD	_	33	nsubjpass	_	_
30	have	have	VBP	VBP	_	33	aux	_	_
31	previously	previously	RB	RB	_	33	advmod	_	_
32	been	be	VBN	VBN	_	33	auxpass	_	_
33	described	describe	VBN	VBN	_	21	acl:relcl	_	_
34	.	.	.	.	_	14	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	a	a	DT	DT	_	7	det	_	_
7	majority	majority	NN	NN	_	12	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	4	ccomp	_	_
13	at	at	IN	IN	_	15	case	_	_
14	comparable	comparable	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	U-937	u-937	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HeLa	hela	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	large	large	JJ	JJ	_	3	amod	_	_
3	number	number	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	individual	individual	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	represented	represent	VBN	VBN	_	6	acl	_	_
8	among	among	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	63	63	CD	CD	_	11	nummod	_	_
11	clones	clone	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
14	apparent	apparent	JJ	JJ	_	15	amod	_	_
15	non-cell-type-specific	non-cell-type-specific	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	3	conj	_	_
17	suggest	suggest	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	28	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	majority	majority	NN	NN	_	28	nsubj	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	Kruppel-related	kruppel-related	JJ	JJ	_	26	amod	_	_
24	zinc	zinc	NN	NN	_	26	compound	_	_
25	finger	finger	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	20	nmod	_	_
27	are	be	VBP	VBP	_	28	cop	_	_
28	likely	likely	JJ	JJ	_	17	ccomp	_	_
29	to	to	TO	TO	_	31	mark	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	expressed	express	VBN	VBN	_	28	xcomp	_	_
32	in	in	IN	IN	_	35	case	_	_
33	most	most	JJS	JJS	_	34	dep	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	tissues	tissue	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	some	some	DT	DT	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	displayed	display	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	restricted	restricted	JJ	JJ	_	12	amod	_	_
11	expression	expression	NN	NN	_	12	compound	_	_
12	pattern	pattern	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	8	punct	_	_
14	indicating	indicate	VBG	VBG	_	8	advcl	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	represent	represent	VBP	VBP	_	14	ccomp	_	_
18	potential	potential	JJ	JJ	_	19	amod	_	_
19	regulators	regulator	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	monocyte	monocyte	NN	NN	_	19	nmod	_	_
22	differentiation	differentiation	NN	NN	_	21	dep	_	_
23	or	or	CC	CC	_	21	cc	_	_
24	proliferation	proliferation	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	Detailed	detailed	JJ	JJ	_	3	amod	_	_
2	structural	structural	JJ	JJ	_	1	dep	_	_
3	analysis	analysis	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	first	first	JJ	JJ	_	8	amod	_	_
7	12	12	CD	CD	_	8	nummod	_	_
8	cDNAs	cdna	NNS	NNS	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	HZF	hzf	NN	NN	_	8	appos	_	_
11	1-10	1-10	CD	CD	_	10	nummod	_	_
12	)	)	-RRB-	-RRB-	_	10	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	partial	partial	JJ	JJ	_	16	amod	_	_
16	characterization	characterization	NN	NN	_	3	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HZF	hzf	NN	NN	_	16	nmod	_	_
19	11-42	11-42	CD	CD	_	18	nummod	_	_
20	revealed	reveal	VBD	VBD	_	0	root	_	_
21	that	that	IN	IN	_	33	mark	_	_
22	a	a	DT	DT	_	24	det	_	_
23	common	common	JJ	JJ	_	24	amod	_	_
24	feature	feature	NN	NN	_	33	nsubj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	human	human	JJ	JJ	_	30	amod	_	_
27	Kruppel-related	kruppel-related	JJ	JJ	_	30	amod	_	_
28	zinc	zinc	NN	NN	_	30	compound	_	_
29	finger	finger	NN	NN	_	30	compound	_	_
30	proteins	protein	NNS	NNS	_	24	nmod	_	_
31	is	be	VBZ	VBZ	_	33	cop	_	_
32	the	the	DT	DT	_	33	det	_	_
33	presence	presence	NN	NN	_	20	ccomp	_	_
34	of	of	IN	IN	_	36	case	_	_
35	tandem	tandem	JJ	JJ	_	36	amod	_	_
36	arrays	array	NNS	NNS	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	zinc	zinc	NN	NN	_	39	compound	_	_
39	fingers	finger	NNS	NNS	_	36	nmod	_	_
40	ranging	range	VBG	VBG	_	36	acl	_	_
41	in	in	IN	IN	_	42	case	_	_
42	number	number	NN	NN	_	40	nmod	_	_
43	from	from	IN	IN	_	44	case	_	_
44	3	3	CD	CD	_	40	nmod	_	_
45	to	to	TO	TO	_	47	case	_	_
46	over	over	IN	IN	_	47	advmod	_	_
47	20	20	CD	CD	_	40	nmod	_	_
48	that	that	WDT	WDT	_	51	nsubj	_	_
49	are	be	VBP	VBP	_	51	cop	_	_
50	preferentially	preferentially	RB	RB	_	51	advmod	_	_
51	located	located	JJ	JJ	_	36	acl:relcl	_	_
52	in	in	IN	IN	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	carboxy-terminal	carboxy-terminal	JJ	JJ	_	55	amod	_	_
55	regions	region	NNS	NNS	_	51	nmod	_	_
56	of	of	IN	IN	_	58	case	_	_
57	the	the	DT	DT	_	58	det	_	_
58	proteins	protein	NNS	NNS	_	55	nmod	_	_
59	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	novel	novel	JJ	JJ	_	9	amod	_	_
6	KRAB-containing	krab-containing	JJ	JJ	_	9	amod	_	_
7	zinc	zinc	NN	NN	_	9	compound	_	_
8	finger	finger	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	17	nsubjpass	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	15	det	_	_
12	novel	novel	JJ	JJ	_	15	amod	_	_
13	conserved	conserve	VBN	VBN	_	15	amod	_	_
14	sequence	sequence	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	9	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	identified	identify	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Deleted	deleted	JJ	JJ	_	2	amod	_	_
2	chromosome	chromosome	NN	NN	_	0	root	_	_
3	20	20	CD	CD	_	2	nummod	_	_
4	from	from	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	patient	patient	NN	NN	_	2	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	Alagille	alagille	NN	NN	_	9	compound	_	_
9	syndrome	syndrome	NN	NN	_	6	nmod	_	_
10	isolated	isolate	VBN	VBN	_	2	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	hybrid	hybrid	NN	NN	_	10	nmod	_	_
15	through	through	IN	IN	_	18	case	_	_
16	leucine	leucine	NN	NN	_	18	compound	_	_
17	transport	transport	NN	NN	_	18	compound	_	_
18	selection	selection	NN	NN	_	10	nmod	_	_
19	:	:	:	:	_	2	punct	_	_
20	study	study	NN	NN	_	2	dep	_	_
21	of	of	IN	IN	_	24	case	_	_
22	three	three	CD	CD	_	24	nummod	_	_
23	candidate	candidate	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	Alagille	alagille	NN	NN	_	2	compound	_	_
2	syndrome	syndrome	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	AGS	ags	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	well-defined	well-defined	JJ	JJ	_	10	amod	_	_
9	genetic	genetic	JJ	JJ	_	10	amod	_	_
10	entity	entity	NN	NN	_	0	root	_	_
11	assigned	assign	VBN	VBN	_	10	acl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	short	short	JJ	JJ	_	15	amod	_	_
15	arm	arm	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	Chromosome	chromosome	NN	NN	_	19	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Chr	chr	NN	NN	_	15	nmod	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	20	20	CD	CD	_	19	nummod	_	_
22	by	by	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	series	series	NN	NN	_	11	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	observations	observation	NNS	NNS	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	AGS	ags	NN	NN	_	29	compound	_	_
29	patients	patient	NNS	NNS	_	26	nmod	_	_
30	associated	associate	VBN	VBN	_	26	acl	_	_
31	with	with	IN	IN	_	32	case	_	_
32	microdeletions	microdeletion	NNS	NNS	_	30	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	this	this	DT	DT	_	35	det	_	_
35	region	region	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	fusing	fuse	VBG	VBG	_	38	advcl	_	_
3	lymphoblastoid	lymphoblastoid	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	AGS	ags	NN	NN	_	8	compound	_	_
8	patient	patient	NN	NN	_	4	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	exhibited	exhibit	VBD	VBD	_	4	acl:relcl	_	_
11	a	a	DT	DT	_	12	det	_	_
12	microdeletion	microdeletion	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	short	short	JJ	JJ	_	18	amod	_	_
16	arm	arm	NN	NN	_	18	compound	_	_
17	of	of	IN	IN	_	18	amod	_	_
18	Chr	chr	NN	NN	_	10	nmod	_	_
19	20	20	CD	CD	_	18	nummod	_	_
20	encompassing	encompassing	NN	NN	_	18	dep	_	_
21	bands	band	NNS	NNS	_	20	dobj	_	_
22	p11.23	p11.23	NN	NN	_	21	dep	_	_
23	to	to	TO	TO	_	22	dep	_	_
24	p12.3	p12.3	VB	VB	_	22	dep	_	_
25	with	with	IN	IN	_	29	case	_	_
26	rodent	rodent	JJ	JJ	_	29	amod	_	_
27	thermosensitive	thermosensitive	JJ	JJ	_	29	amod	_	_
28	mutant	mutant	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	2	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CHOtsH1-1	chotsh1-1	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	deficient	deficient	JJ	JJ	_	29	amod	_	_
34	in-leucyl-tRNA	in-leucyl-trna	JJ	JJ	_	35	amod	_	_
35	synthetase	synthetase	NN	NN	_	33	dep	_	_
36	,	,	,	,	_	38	punct	_	_
37	we	we	PRP	PRP	_	38	nsubj	_	_
38	isolated	isolate	VBD	VBD	_	0	root	_	_
39	a	a	DT	DT	_	42	det	_	_
40	somatic	somatic	JJ	JJ	_	42	amod	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	hybrid	hybrid	NN	NN	_	38	dobj	_	_
43	segregating	segregate	VBG	VBG	_	42	acl	_	_
44	the	the	DT	DT	_	47	det	_	_
45	deleted	deleted	JJ	JJ	_	47	amod	_	_
46	human	human	JJ	JJ	_	47	amod	_	_
47	Chr	chr	NN	NN	_	43	dobj	_	_
48	20	20	CD	CD	_	47	nummod	_	_
49	.	.	.	.	_	38	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	hybrid	hybrid	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	9	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	designated	designate	VBN	VBN	_	3	acl	_	_
6	NR2	nr2	NN	NN	_	5	xcomp	_	_
7	,	,	,	,	_	3	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	characterized	characterize	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	methods	method	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	including	include	VBG	VBG	_	15	case	_	_
15	PCR	pcr	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	eight	eight	CD	CD	_	19	nummod	_	_
19	pairs	pair	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	oligonucleotides	oligonucleotide	NNS	NNS	_	19	nmod	_	_
22	mapped	map	VBN	VBN	_	19	acl	_	_
23	to	to	TO	TO	_	24	case	_	_
24	Chr	chr	NN	NN	_	22	nmod	_	_
25	20	20	CD	CD	_	24	nummod	_	_
26	:	:	:	:	_	9	punct	_	_
27	D20S5	d20s5	NN	NN	_	9	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	D20S41	d20s41	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	D20S42	d20s42	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	D20S56	d20s56	NN	NN	_	27	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	D20S57	d20s57	NN	NN	_	27	conj	_	_
36	,	,	,	,	_	27	punct	_	_
37	D20S58	d20s58	NN	NN	_	27	conj	_	_
38	,	,	,	,	_	27	punct	_	_
39	adenosine	adenosine	NN	NN	_	40	compound	_	_
40	deaminase	deaminase	NN	NN	_	27	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	ADA	ada	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	27	punct	_	_
45	and	and	CC	CC	_	27	cc	_	_
46	Prion	prion	NN	NN	_	47	compound	_	_
47	protein	protein	NN	NN	_	27	conj	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	PRIP	prip	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	;	;	:	:	_	9	punct	_	_
52	Restriction	restriction	NN	NN	_	55	compound	_	_
53	Fragment	fragment	NN	NN	_	55	compound	_	_
54	Length	length	NN	NN	_	55	compound	_	_
55	Polymorphism	polymorphism	NN	NN	_	59	compound	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	RFLP	rflp	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	analyses	analysis	NNS	NNS	_	9	dep	_	_
60	with	with	IN	IN	_	64	case	_	_
61	four	four	CD	CD	_	64	nummod	_	_
62	genomic	genomic	JJ	JJ	_	64	amod	_	_
63	anonymous	anonymous	JJ	JJ	_	64	amod	_	_
64	probes	probe	NNS	NNS	_	59	nmod	_	_
65	(	(	-LRB-	-LRB-	_	66	punct	_	_
66	D20S5	d20s5	NN	NN	_	64	dep	_	_
67	,	,	,	,	_	66	punct	_	_
68	cD3H12	cd3h12	NN	NN	_	66	appos	_	_
69	,	,	,	,	_	66	punct	_	_
70	D20S17	d20s17	NN	NN	_	66	appos	_	_
71	,	,	,	,	_	66	punct	_	_
72	D20S18	d20s18	NN	NN	_	66	appos	_	_
73	)	)	-RRB-	-RRB-	_	66	punct	_	_
74	;	;	:	:	_	9	punct	_	_
75	and	and	CC	CC	_	9	cc	_	_
76	fluorescent	fluorescent	JJ	JJ	_	79	amod	_	_
77	in	in	FW	FW	_	79	amod	_	_
78	situ	situ	FW	FW	_	77	dep	_	_
79	hybridization	hybridization	NN	NN	_	9	conj	_	_
80	(	(	-LRB-	-LRB-	_	81	punct	_	_
81	FISH	fish	NN	NN	_	79	appos	_	_
82	)	)	-RRB-	-RRB-	_	81	punct	_	_
83	with	with	IN	IN	_	86	case	_	_
84	total	total	JJ	JJ	_	86	amod	_	_
85	human	human	JJ	JJ	_	86	amod	_	_
86	DNA	dna	NN	NN	_	79	nmod	_	_
87	and	and	CC	CC	_	86	cc	_	_
88	D20Z1	d20z1	NN	NN	_	86	conj	_	_
89	,	,	,	,	_	88	punct	_	_
90	a	a	DT	DT	_	91	det	_	_
91	sequence	sequence	NN	NN	_	88	appos	_	_
92	specific	specific	JJ	JJ	_	91	amod	_	_
93	to	to	TO	TO	_	98	case	_	_
94	the	the	DT	DT	_	98	det	_	_
95	human	human	JJ	JJ	_	98	amod	_	_
96	Chr	chr	NN	NN	_	98	compound	_	_
97	20	20	CD	CD	_	98	nummod	_	_
98	centromere	centromere	NN	NN	_	92	nmod	_	_
99	,	,	,	,	_	79	punct	_	_
100	as	as	IN	IN	_	101	case	_	_
101	probes	probe	NNS	NNS	_	79	nmod	_	_
102	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NR2	nr2	NN	NN	_	3	compound	_	_
3	hybrid	hybrid	NN	NN	_	4	nsubj	_	_
4	allowed	allow	VBD	VBD	_	0	root	_	_
5	us	we	PRP	PRP	_	4	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	exclude	exclude	VB	VB	_	4	xcomp	_	_
8	three	three	CD	CD	_	10	nummod	_	_
9	candidate	candidate	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	7	dobj	_	_
11	for	for	IN	IN	_	12	case	_	_
12	AGS	ags	NN	NN	_	10	nmod	_	_
13	:	:	:	:	_	4	punct	_	_
14	hepatic	hepatic	JJ	JJ	_	18	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
16	factor	factor	NN	NN	_	18	compound	_	_
17	3	3	CD	CD	_	18	nummod	_	_
18	beta	beta	NN	NN	_	4	dep	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	HNF3	hnf3	NN	NN	_	21	compound	_	_
21	beta	beta	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	18	punct	_	_
24	paired	paired	JJ	JJ	_	25	amod	_	_
25	box	box	NN	NN	_	18	conj	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PAX1	pax1	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	18	punct	_	_
31	and	and	CC	CC	_	18	cc	_	_
32	cystatin	cystatin	NN	NN	_	33	compound	_	_
33	C	c	NN	NN	_	18	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	CST3	cst3	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	as	as	IN	IN	_	38	mark	_	_
38	shown	show	VBN	VBN	_	18	dep	_	_
39	by	by	IN	IN	_	41	case	_	_
40	their	they	PRP$	PRP$	_	41	nmod:poss	_	_
41	localization	localization	NN	NN	_	38	nmod	_	_
42	outside	outside	JJ	JJ	_	41	amod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	deletion	deletion	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NR2	nr2	NN	NN	_	3	compound	_	_
3	hybrid	hybrid	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	powerful	powerful	JJ	JJ	_	7	amod	_	_
7	tool	tool	NN	NN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	mapping	mapping	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	new	new	JJ	JJ	_	13	amod	_	_
13	probes	probe	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	region	region	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	as	as	RB	RB	_	10	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	for	for	IN	IN	_	22	mark	_	_
22	obtaining	obtain	VBG	VBG	_	10	conj	_	_
23	new	new	JJ	JJ	_	25	amod	_	_
24	informative	informative	JJ	JJ	_	23	dep	_	_
25	probes	probe	NNS	NNS	_	22	dobj	_	_
26	specific	specific	JJ	JJ	_	25	amod	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	deletion	deletion	NN	NN	_	26	nmod	_	_
30	by	by	IN	IN	_	32	case	_	_
31	subtractive	subtractive	JJ	JJ	_	32	amod	_	_
32	cloning	cloning	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	region	region	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	markers	marker	NNS	NNS	_	5	nsubj	_	_
3	will	will	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	cop	_	_
5	useful	useful	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	linkage	linkage	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	screening	screening	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cDNA	cdna	NN	NN	_	13	compound	_	_
13	libraries	library	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Control	control	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	I	i	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B-alpha	b-alpha	NN	NN	_	6	compound	_	_
6	proteolysis	proteolysis	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	site-specific	site-specific	JJ	JJ	_	11	amod	_	_
9	,	,	,	,	_	8	punct	_	_
10	signal-induced	signal-induced	JJ	JJ	_	8	dep	_	_
11	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	I	i	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B-alpha	b-alpha	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	4	dobj	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	6	dep	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	retaining	retain	VBG	VBG	_	4	advcl	_	_
11	it	it	PRP	PRP	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	stimuli	stimulus	NNS	NNS	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	typically	typically	RB	RB	_	5	advmod	_	_
5	those	those	DT	DT	_	2	appos	_	_
6	associated	associate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	stress	stress	NN	NN	_	6	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	pathogens	pathogen	NNS	NNS	_	8	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	inactivate	inactivate	VBP	VBP	_	0	root	_	_
14	I	i	NN	NN	_	16	compound	_	_
15	kappa	kappa	NN	NN	_	16	compound	_	_
16	B-alpha	b-alpha	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	liberates	liberate	VBZ	VBZ	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	translocate	translocate	VB	VB	_	2	advcl	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	initiate	initiate	VB	VB	_	2	conj	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	genes	gene	NNS	NNS	_	12	nmod	_	_
15	important	important	JJ	JJ	_	14	amod	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	defense	defense	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	organism	organism	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	correlates	correlate	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	I	i	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B-alpha	b-alpha	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	requires	require	VBZ	VBZ	_	5	conj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	proteolysis	proteolysis	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	inhibitor	inhibitor	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	11	advmod	_	_
2	either	either	CC	CC	_	3	cc:preconj	_	_
3	serine-32	serine-32	NN	NN	_	11	nsubjpass	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	serine-36	serine-36	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	I	i	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B-alpha	b-alpha	NN	NN	_	3	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	mutated	mutate	VBN	VBN	_	17	advcl	_	_
12	,	,	,	,	_	17	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	protein	protein	NN	NN	_	17	nsubj	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	undergo	undergo	VB	VB	_	0	root	_	_
18	signal-induced	signal-induced	JJ	JJ	_	19	amod	_	_
19	phosphorylation	phosphorylation	NN	NN	_	17	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	degradation	degradation	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	29	nsubjpass	_	_
26	could	could	MD	MD	_	29	aux	_	_
27	not	not	RB	RB	_	29	neg	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	activated	activate	VBN	VBN	_	17	conj	_	_
30	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	phosphorylation	phosphorylation	NN	NN	_	14	nsubj	_	_
6	at	at	IN	IN	_	7	case	_	_
7	one	one	CD	CD	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	both	both	DT	DT	_	7	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	residues	residue	NNS	NNS	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	critical	critical	JJ	JJ	_	3	ccomp	_	_
15	for	for	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	germline	germline	NN	NN	_	7	compound	_	_
3	TaqI	taqi	NN	NN	_	7	compound	_	_
4	restriction	restriction	NN	NN	_	7	compound	_	_
5	fragment	fragment	NN	NN	_	7	compound	_	_
6	length	length	NN	NN	_	7	compound	_	_
7	polymorphism	polymorphism	NN	NN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	progesterone	progesterone	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	ovarian	ovarian	JJ	JJ	_	15	amod	_	_
15	carcinoma	carcinoma	NN	NN	_	12	nmod	_	_
16	-LSB-	-lsb-	-LRB-	-LRB-	_	17	punct	_	_
17	see	see	VB	VB	_	7	dep	_	_
18	comments	comment	NNS	NNS	_	17	dobj	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	17	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	outcome	outcome	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	ovarian	ovarian	JJ	JJ	_	5	amod	_	_
5	carcinoma	carcinoma	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	predicted	predict	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	progesterone	progesterone	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	status	status	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	indicating	indicate	VBG	VBG	_	7	advcl	_	_
14	an	a	DT	DT	_	16	det	_	_
15	endocrine	endocrine	JJ	JJ	_	16	amod	_	_
16	aspect	aspect	NN	NN	_	13	dobj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	disease	disease	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	leucocyte	leucocyte	NN	NN	_	4	compound	_	_
3	genomic	genomic	JJ	JJ	_	4	amod	_	_
4	DNAs	dna	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	obtained	obtain	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	9	case	_	_
8	41	41	CD	CD	_	9	nummod	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	primary	primary	JJ	JJ	_	13	amod	_	_
12	ovarian	ovarian	JJ	JJ	_	13	amod	_	_
13	carcinoma	carcinoma	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	83	83	CD	CD	_	16	nummod	_	_
16	controls	control	NNS	NNS	_	9	conj	_	_
17	from	from	IN	IN	_	18	case	_	_
18	Ireland	Ireland	NNP	NNP	_	9	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	as	as	RB	RB	_	9	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	from	from	IN	IN	_	28	case	_	_
24	26	26	CD	CD	_	28	nummod	_	_
25	primary	primary	JJ	JJ	_	28	amod	_	_
26	ovarian	ovarian	JJ	JJ	_	28	amod	_	_
27	carcinoma	carcinoma	NN	NN	_	28	compound	_	_
28	patients	patient	NNS	NNS	_	9	conj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	101	101	CD	CD	_	31	nummod	_	_
31	controls	control	NNS	NNS	_	28	conj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	Germany	Germany	NNP	NNP	_	28	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Southern	southern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	13	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	a	a	DT	DT	_	12	det	_	_
5	human	human	JJ	JJ	_	12	amod	_	_
6	progesterone	progesterone	NN	NN	_	12	compound	_	_
7	receptor	receptor	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	hPR	hpr	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	cDNA	cdna	NN	NN	_	12	compound	_	_
12	probe	probe	NN	NN	_	3	dobj	_	_
13	identified	identify	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	20	det	_	_
15	germline	germline	NN	NN	_	20	compound	_	_
16	TaqI	taqi	NN	NN	_	20	compound	_	_
17	restriction	restriction	NN	NN	_	20	compound	_	_
18	fragment	fragment	NN	NN	_	20	compound	_	_
19	length	length	NN	NN	_	20	compound	_	_
20	polymorphism	polymorphism	NN	NN	_	13	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	RFLP	rflp	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	defined	define	VBN	VBN	_	20	acl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	two	two	CD	CD	_	27	nummod	_	_
27	alleles	allele	NNS	NNS	_	24	nmod	_	_
28	:	:	:	:	_	13	punct	_	_
29	T1	t1	NN	NN	_	13	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	represented	represent	VBN	VBN	_	29	acl	_	_
32	by	by	IN	IN	_	36	case	_	_
33	a	a	DT	DT	_	36	det	_	_
34	2.7	2.7	CD	CD	_	36	nummod	_	_
35	kb	kb	NN	NN	_	36	compound	_	_
36	fragment	fragment	NN	NN	_	31	nmod	_	_
37	;	;	:	:	_	29	punct	_	_
38	and	and	CC	CC	_	29	cc	_	_
39	T2	t2	NN	NN	_	29	conj	_	_
40	,	,	,	,	_	39	punct	_	_
41	represented	represent	VBN	VBN	_	39	dep	_	_
42	by	by	IN	IN	_	46	case	_	_
43	a	a	DT	DT	_	46	det	_	_
44	1.9	1.9	CD	CD	_	46	nummod	_	_
45	kb	kb	NN	NN	_	46	compound	_	_
46	fragment	fragment	NN	NN	_	41	nmod	_	_
47	and	and	CC	CC	_	41	cc	_	_
48	characterised	characterise	VBN	VBN	_	41	conj	_	_
49	by	by	IN	IN	_	54	case	_	_
50	an	a	DT	DT	_	54	det	_	_
51	additional	additional	JJ	JJ	_	54	amod	_	_
52	TaqI	taqi	NN	NN	_	54	compound	_	_
53	restriction	restriction	NN	NN	_	54	compound	_	_
54	site	site	NN	NN	_	48	nmod	_	_
55	with	with	IN	IN	_	56	case	_	_
56	respect	respect	NN	NN	_	48	nmod	_	_
57	to	to	TO	TO	_	58	case	_	_
58	T1	t1	NN	NN	_	56	nmod	_	_
59	.	.	.	.	_	13	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	over-representation	over-representation	NN	NN	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	T2	t2	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	ovarian	ovarian	JJ	JJ	_	8	amod	_	_
7	cancer	cancer	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	2	nmod	_	_
9	compared	compare	VBN	VBN	_	2	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	controls	control	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	pooled	pooled	JJ	JJ	_	16	amod	_	_
15	Irish/German	Irish/German	NNP	NNP	_	16	compound	_	_
16	population	population	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	P	p	NN	NN	_	11	dep	_	_
19	&lt;	&lt;	JJR	JJR	_	18	amod	_	_
20	0.025	0.025	CD	CD	_	19	dep	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	observed	observe	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	23	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	P	p	NN	NN	_	2	dep	_	_
5	&lt;	&lt;	JJR	JJR	_	4	amod	_	_
6	0.02	0.02	CD	CD	_	5	dep	_	_
7	)	)	-RRB-	-RRB-	_	4	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	distribution	distribution	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	RFLP	rflp	NN	NN	_	14	compound	_	_
14	genotypes	genotype	NNS	NNS	_	10	nmod	_	_
15	between	between	IN	IN	_	16	case	_	_
16	Irish	Irish	NNP	NNP	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	German	German	NNP	NNP	_	16	conj	_	_
19	control	control	JJ	JJ	_	20	amod	_	_
20	populations	population	NNS	NNS	_	16	dep	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	observed	observe	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	allele	allele	NN	NN	_	3	compound	_	_
3	distributions	distribution	NNS	NNS	_	7	nsubjpass	_	_
4	could	could	MD	MD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	differ	differ	VB	VB	_	7	xcomp	_	_
10	significantly	significantly	RB	RB	_	9	advmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	Hardy-Weinberg	hardy-weinberg	JJ	JJ	_	13	amod	_	_
13	distribution	distribution	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	any	any	DT	DT	_	16	det	_	_
16	subgroup	subgroup	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	hPR	hpr	NN	NN	_	5	compound	_	_
3	cDNA	cdna	NN	NN	_	5	compound	_	_
4	region-specific	region-specific	JJ	JJ	_	5	amod	_	_
5	probes	probe	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	the	the	DT	DT	_	11	det	_	_
8	extra	extra	JJ	JJ	_	11	amod	_	_
9	TaqI	taqi	NN	NN	_	11	compound	_	_
10	restriction	restriction	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	mapped	map	VBN	VBN	_	1	parataxis	_	_
14	to	to	TO	TO	_	16	case	_	_
15	intron	intron	NN	NN	_	16	compound	_	_
16	G	g	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	hPR	hpr	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	Nef	nef	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	5	case	_	_
5	inhibition	inhibition	NN	NN	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	activation	activation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	depending	depend	VBG	VBG	_	15	case	_	_
12	on	on	IN	IN	_	15	case	_	_
13	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
14	intracellular	intracellular	JJ	JJ	_	15	amod	_	_
15	localization	localization	NN	NN	_	3	advcl	_	_
16	.	.	.	.	_	3	punct	_	_

1	Nef	nef	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	primate	primate	JJ	JJ	_	4	amod	_	_
4	lentiviruses	lentivirus	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	viremia	viremia	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	progression	progression	NN	NN	_	8	conj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	AIDS	aids	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	monkeys	monkey	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Negative	negative	JJ	JJ	_	13	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	positive	positive	JJ	JJ	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	no	no	DT	DT	_	1	conj	_	_
7	effects	effect	NNS	NNS	_	1	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Nef	nef	NN	NN	_	7	nmod	_	_
10	have	have	VBP	VBP	_	13	aux	_	_
11	also	also	RB	RB	_	13	advmod	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	reported	report	VBN	VBN	_	0	root	_	_
14	on	on	IN	IN	_	16	case	_	_
15	viral	viral	JJ	JJ	_	16	amod	_	_
16	replication	replication	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	reconcile	reconcile	VB	VB	_	0	root	_	_
3	these	these	DT	DT	_	4	det	_	_
4	observations	observation	NNS	NNS	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	expressed	express	VBD	VBD	_	2	parataxis	_	_
8	a	a	DT	DT	_	11	det	_	_
9	hybrid	hybrid	NN	NN	_	11	compound	_	_
10	CD8-Nef	cd8-nef	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	opposite	opposite	JJ	JJ	_	3	amod	_	_
3	phenotypes	phenotype	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	depended	depend	VBD	VBD	_	5	dep	_	_
9	on	on	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
12	localization	localization	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Nef	nef	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Expressed	express	VBN	VBN	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cytoplasm	cytoplasm	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	surface	surface	NN	NN	_	4	conj	_	_
10	,	,	,	,	_	1	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	chimera	chimera	NN	NN	_	13	nsubj	_	_
13	inhibited	inhibit	VBD	VBD	_	1	parataxis	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	activated	activate	VBD	VBD	_	13	conj	_	_
16	early	early	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	events	event	NNS	NNS	_	13	dobj	_	_
19	from	from	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	antigen	antigen	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	died	die	VBD	VBD	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	only	only	RB	RB	_	18	advmod	_	_
10	cells	cell	NNS	NNS	_	18	nsubj	_	_
11	with	with	IN	IN	_	14	case	_	_
12	mutated	mutate	VBN	VBN	_	14	amod	_	_
13	nef	nef	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	expressing	express	VBG	VBG	_	14	acl	_	_
16	truncated	truncate	VBN	VBN	_	17	amod	_	_
17	Nefs	nef	NNS	NNS	_	15	dobj	_	_
18	survived	survive	VBD	VBD	_	4	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	rendered	render	VBD	VBD	_	18	dep	_	_
22	Nef	nef	NN	NN	_	21	xcomp	_	_
23	nonfunctional	nonfunctional	JJ	JJ	_	22	amod	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	mutations	mutation	NNS	NNS	_	3	nsubj	_	_
3	paralleled	parallel	VBD	VBD	_	0	root	_	_
4	those	those	DT	DT	_	3	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	viral	viral	JJ	JJ	_	8	amod	_	_
8	strains	strain	NNS	NNS	_	4	nmod	_	_
9	passaged	passage	VBN	VBN	_	8	acl	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Not	not	RB	RB	_	2	neg	_	_
2	only	only	RB	RB	_	9	dep	_	_
3	do	do	VBP	VBP	_	9	aux	_	_
4	these	these	DT	DT	_	6	det	_	_
5	positional	positional	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Nef	nef	NN	NN	_	6	nmod	_	_
9	reconcile	reconcile	VB	VB	_	0	root	_	_
10	diverse	diverse	JJ	JJ	_	11	amod	_	_
11	phenotypes	phenotype	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Nef	nef	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	suggest	suggest	VB	VB	_	9	conj	_	_
16	a	a	DT	DT	_	17	det	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	21	case	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	N-terminal	n-terminal	JJ	JJ	_	21	amod	_	_
21	myristylation	myristylation	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	but	but	CC	CC	_	9	cc	_	_
24	they	they	PRP	PRP	_	26	nsubj	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	explain	explain	VBP	VBP	_	9	conj	_	_
27	effects	effect	NNS	NNS	_	26	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	Nef	nef	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	HIV	hiv	NN	NN	_	32	compound	_	_
32	infection	infection	NN	NN	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	progression	progression	NN	NN	_	32	conj	_	_
35	to	to	TO	TO	_	36	case	_	_
36	AIDS	aids	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	Missense	missense	NN	NN	_	2	compound	_	_
2	mutation	mutation	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	exon	exon	NN	NN	_	2	nmod	_	_
5	7	7	CD	CD	_	4	nummod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	common	common	JJ	JJ	_	11	amod	_	_
9	gamma	gamma	NN	NN	_	11	compound	_	_
10	chain	chain	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	2	nmod	_	_
12	causes	cause	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	moderate	moderate	JJ	JJ	_	15	amod	_	_
15	form	form	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	X-linked	x-linked	JJ	JJ	_	19	amod	_	_
18	combined	combined	JJ	JJ	_	19	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Clinical	clinical	JJ	JJ	_	16	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	immunologic	immunologic	JJ	JJ	_	1	conj	_	_
4	features	feature	NNS	NNS	_	1	dep	_	_
5	of	of	IN	IN	_	12	case	_	_
6	a	a	DT	DT	_	12	det	_	_
7	recently	recently	RB	RB	_	8	advmod	_	_
8	recognized	recognize	VBN	VBN	_	12	amod	_	_
9	X-linked	x-linked	JJ	JJ	_	12	amod	_	_
10	combined	combined	JJ	JJ	_	12	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
12	disease	disease	NN	NN	_	1	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	XCID	xcid	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	suggested	suggest	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	28	mark	_	_
18	XCID	xcid	NN	NN	_	28	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	X-linked	x-linked	JJ	JJ	_	23	amod	_	_
21	severe	severe	JJ	JJ	_	23	amod	_	_
22	combined	combined	JJ	JJ	_	23	amod	_	_
23	immunodeficiency	immunodeficiency	NN	NN	_	18	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	XSCID	xscid	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	might	might	MD	MD	_	28	aux	_	_
28	arise	arise	VB	VB	_	16	ccomp	_	_
29	from	from	IN	IN	_	32	case	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	genetic	genetic	JJ	JJ	_	32	amod	_	_
32	defects	defect	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	discovery	discovery	NN	NN	_	26	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	mutations	mutation	NNS	NNS	_	3	nmod	_	_
6	in	in	IN	IN	_	15	case	_	_
7	the	the	DT	DT	_	15	det	_	_
8	common	common	JJ	JJ	_	15	amod	_	_
9	gamma	gamma	NN	NN	_	15	compound	_	_
10	chain	chain	NN	NN	_	15	compound	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	gamma	gamma	NN	NN	_	15	compound	_	_
13	c	c	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	gene	gene	NN	NN	_	5	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	18	det	_	_
18	constituent	constituent	NN	NN	_	15	appos	_	_
19	of	of	IN	IN	_	22	case	_	_
20	several	several	JJ	JJ	_	22	amod	_	_
21	cytokine	cytokine	NN	NN	_	22	compound	_	_
22	receptors	receptor	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	XSCID	xscid	NN	NN	_	15	nmod	_	_
26	provided	provide	VBD	VBD	_	0	root	_	_
27	an	a	DT	DT	_	28	det	_	_
28	opportunity	opportunity	NN	NN	_	26	dobj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	test	test	VB	VB	_	28	acl	_	_
31	directly	directly	RB	RB	_	30	advmod	_	_
32	whether	whether	IN	IN	_	42	mark	_	_
33	a	a	DT	DT	_	36	det	_	_
34	previously	previously	RB	RB	_	35	advmod	_	_
35	unrecognized	unrecognized	JJ	JJ	_	36	amod	_	_
36	mutation	mutation	NN	NN	_	42	nsubj	_	_
37	in	in	IN	IN	_	40	case	_	_
38	this	this	DT	DT	_	40	det	_	_
39	same	same	JJ	JJ	_	40	amod	_	_
40	gene	gene	NN	NN	_	36	nmod	_	_
41	was	be	VBD	VBD	_	42	cop	_	_
42	responsible	responsible	JJ	JJ	_	30	ccomp	_	_
43	for	for	IN	IN	_	44	case	_	_
44	XCID	xcid	NN	NN	_	42	nmod	_	_
45	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	status	status	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	X	x	NN	NN	_	5	compound	_	_
5	chromosome	chromosome	NN	NN	_	6	compound	_	_
6	inactivation	inactivation	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	blood	blood	NN	NN	_	9	compound	_	_
9	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	obligate	obligate	JJ	JJ	_	12	amod	_	_
12	carriers	carrier	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	XCID	xcid	NN	NN	_	12	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	determined	determine	VBN	VBN	_	0	root	_	_
17	from	from	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	polymorphic	polymorphic	JJ	JJ	_	23	amod	_	_
20	,	,	,	,	_	19	punct	_	_
21	short	short	JJ	JJ	_	19	dep	_	_
22	tandem	tandem	JJ	JJ	_	23	amod	_	_
23	repeats	repeat	NNS	NNS	_	16	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CAG	cag	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	23	punct	_	_
28	in	in	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	androgen	androgen	NN	NN	_	32	compound	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	23	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	which	which	WDT	WDT	_	36	nsubj	_	_
35	also	also	RB	RB	_	36	advmod	_	_
36	contains	contain	VBZ	VBZ	_	32	acl:relcl	_	_
37	a	a	DT	DT	_	40	det	_	_
38	methylation-sensitive	methylation-sensitive	JJ	JJ	_	40	amod	_	_
39	HpaII	hpaii	NN	NN	_	40	compound	_	_
40	site	site	NN	NN	_	36	dobj	_	_
41	.	.	.	.	_	16	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	in	in	IN	IN	_	3	case	_	_
3	XSCID	xscid	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	X-chromosome	x-chromosome	NN	NN	_	6	compound	_	_
6	inactivation	inactivation	NN	NN	_	13	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	obligate	obligate	JJ	JJ	_	9	amod	_	_
9	carriers	carrier	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	XCID	xcid	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	nonrandom	nonrandom	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	T	t	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	B	b	NN	NN	_	15	conj	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	dep	_	_
19	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	X	x	NN	NN	_	5	compound	_	_
5	chromosome	chromosome	NN	NN	_	6	compound	_	_
6	inactivation	inactivation	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	PMNs	pmn	NNS	NNS	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	variable	variable	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Findings	finding	NNS	NNS	_	5	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	analysis	analysis	NN	NN	_	1	nmod	_	_
5	prompted	prompt	VBD	VBD	_	0	root	_	_
6	sequencing	sequencing	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	gamma	gamma	NN	NN	_	11	compound	_	_
10	c	c	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	pedigree	pedigree	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	missense	missense	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	18	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	region	region	NN	NN	_	3	nmod	_	_
7	coding	code	VBG	VBG	_	6	acl	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
11	portion	portion	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	gamma	gamma	NN	NN	_	16	compound	_	_
15	c	c	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	22	case	_	_
20	three	three	CD	CD	_	22	nummod	_	_
21	affected	affect	VBN	VBN	_	22	amod	_	_
22	males	male	NNS	NNS	_	18	nmod	_	_
23	but	but	CC	CC	_	22	cc	_	_
24	not	not	RB	RB	_	28	neg	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	brother	brother	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	18	punct	_	_

1	Therefore	therefore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	point	point	NN	NN	_	5	compound	_	_
5	mutation	mutation	NN	NN	_	11	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	gamma	gamma	NN	NN	_	10	compound	_	_
9	c	c	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	less	less	RBR	RBR	_	15	advmod	_	_
15	severe	severe	JJ	JJ	_	16	amod	_	_
16	degree	degree	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	deficiency	deficiency	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	cellular	cellular	JJ	JJ	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	humoral	humoral	JJ	JJ	_	20	conj	_	_
23	immunity	immunity	NN	NN	_	20	dep	_	_
24	than	than	IN	IN	_	25	case	_	_
25	that	that	DT	DT	_	16	nmod	_	_
26	seen	see	VBN	VBN	_	25	acl	_	_
27	in	in	IN	IN	_	28	case	_	_
28	XSCID	xscid	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	LMP-1	lmp-1	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	2	dobj	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	targeting	target	VBG	VBG	_	2	advcl	_	_
7	the	the	DT	DT	_	13	det	_	_
8	inhibitory	inhibitory	JJ	JJ	_	13	amod	_	_
9	molecule	molecule	NN	NN	_	13	compound	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	6	dobj	_	_
14	.	.	.	.	_	2	punct	_	_

1	LMP-1	lmp-1	NN	NN	_	13	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	7	det	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
5	virus	virus	NN	NN	_	7	compound	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	1	appos	_	_
8	expressed	express	VBN	VBN	_	7	acl	_	_
9	during	during	IN	IN	_	11	case	_	_
10	latent	latent	JJ	JJ	_	11	amod	_	_
11	infection	infection	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	has	have	VBZ	VBZ	_	0	root	_	_
14	oncogenic	oncogenic	JJ	JJ	_	15	amod	_	_
15	properties	property	NNS	NNS	_	13	dobj	_	_
16	,	,	,	,	_	13	punct	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	judged	judge	VBN	VBN	_	13	advcl	_	_
19	from	from	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	ability	ability	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	transform	transform	VB	VB	_	21	acl	_	_
24	B	b	NN	NN	_	23	dobj	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	24	dep	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	rodent	rodent	JJ	JJ	_	28	amod	_	_
28	fibroblasts	fibroblast	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	LMP-1	lmp-1	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	bcl2	bcl2	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	an	a	DT	DT	_	9	det	_	_
9	oncogene	oncogene	NN	NN	_	6	appos	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	protects	protect	VBZ	VBZ	_	9	acl:relcl	_	_
12	cells	cell	NNS	NNS	_	11	dobj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	as	as	RB	RB	_	6	cc	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	as	as	IN	IN	_	16	mwe	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	6	conj	_	_
21	encoding	encode	VBG	VBG	_	20	acl	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	21	dobj	_	_
24	involved	involve	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	regulation	regulation	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	growth	growth	NN	NN	_	30	compound	_	_
30	control	control	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	10	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	LMP-1	lmp-1	NN	NN	_	6	nsubj	_	_
6	upregulates	upregulate	VBZ	VBZ	_	2	acl:relcl	_	_
7	these	these	DT	DT	_	8	det	_	_
8	proteins	protein	NNS	NNS	_	6	dobj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	unknown	unknown	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	10	cc	_	_
13	it	it	PRP	PRP	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	plausible	plausible	JJ	JJ	_	10	conj	_	_
16	that	that	IN	IN	_	18	mark	_	_
17	LMP-1	lmp-1	NN	NN	_	18	nsubj	_	_
18	modifies	modify	VBZ	VBZ	_	15	ccomp	_	_
19	signal	signal	NN	NN	_	21	compound	_	_
20	transduction	transduction	NN	NN	_	21	compound	_	_
21	pathways	pathway	NNS	NNS	_	18	dobj	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	result	result	VBP	VBP	_	21	acl:relcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	one	one	CD	CD	_	26	nmod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	more	more	JJR	JJR	_	28	conj	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	28	dep	_	_
33	that	that	WDT	WDT	_	35	nsubj	_	_
34	ultimately	ultimately	RB	RB	_	35	advmod	_	_
35	regulate	regulate	VBP	VBP	_	32	acl:relcl	_	_
36	transcription	transcription	NN	NN	_	35	dobj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	oncogenic	oncogenic	JJ	JJ	_	39	amod	_	_
39	genes	gene	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	10	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	22	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	2	appos	_	_
7	controlling	control	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	genes	gene	NNS	NNS	_	9	nmod	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	growth	growth	NN	NN	_	18	compound	_	_
18	control	control	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	2	punct	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	activated	activate	VBN	VBN	_	22	xcomp	_	_
26	by	by	IN	IN	_	27	case	_	_
27	LMP-1	lmp-1	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	mechanism	mechanism	NN	NN	_	4	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	s	s	NNS	NNS	_	9	nsubj	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	regulating	regulate	VBG	VBG	_	4	acl	_	_
7	this	this	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	remains	remain	VBZ	VBZ	_	0	root	_	_
10	unknown	unknown	JJ	JJ	_	9	xcomp	_	_
11	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	increased	increase	VBN	VBN	_	7	amod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	14	nsubj	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	7	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	functional	functional	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	9	conj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	present	present	JJ	JJ	_	3	ccomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	B-lymphoid	b-lymphoid	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	stably	stably	RB	RB	_	19	advmod	_	_
19	or	or	CC	CC	_	17	advmod	_	_
20	transiently	transiently	RB	RB	_	19	advmod	_	_
21	expressing	express	VBG	VBG	_	17	acl	_	_
22	LMP-1	lmp-1	NN	NN	_	21	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	I	i	NN	NN	_	4	compound	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	selectively	selectively	RB	RB	_	7	advmod	_	_
7	modified	modify	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	LMP-1-expressing	lmp-1-expressing	JJ	JJ	_	11	amod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	phosphorylated	phosphorylated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	turnover-degradation	turnover-degradation	NN	NN	_	3	conj	_	_
13	correlate	correlate	VBP	VBP	_	0	root	_	_
14	with	with	IN	IN	_	19	case	_	_
15	increased	increase	VBN	VBN	_	19	amod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	translocation	translocation	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	results	result	VBZ	VBZ	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B-dependent-genes	b-dependent-gene	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	11	case	_	_
11	those	those	DT	DT	_	8	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	p105	p105	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	I	i	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	13	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	MAD3	mad3	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	LMP-1	lmp-1	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	6	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	targeting	target	VBG	VBG	_	6	advcl	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	pathways	pathway	NNS	NNS	_	1	nmod	_	_
5	activated	activate	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	LMP-1	lmp-1	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	result	result	VB	VB	_	5	xcomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	posttranslational	posttranslational	JJ	JJ	_	12	amod	_	_
12	modifications	modification	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	nmod	_	_
18	will	will	MD	MD	_	19	aux	_	_
19	aid	aid	VB	VB	_	0	root	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	determining	determine	VBG	VBG	_	19	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	role	role	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	29	case	_	_
25	this	this	DT	DT	_	29	det	_	_
26	virus-host	virus-host	JJ	JJ	_	29	amod	_	_
27	cell	cell	NN	NN	_	29	compound	_	_
28	protein	protein	NN	NN	_	29	compound	_	_
29	interaction	interaction	NN	NN	_	23	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	Epstein-Barr	epstein-barr	JJ	JJ	_	33	amod	_	_
32	virus-mediated	virus-mediated	JJ	JJ	_	33	amod	_	_
33	oncogenesis	oncogenesis	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	19	punct	_	_

1	Treatment	treatment	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HL60	hl60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	various	various	JJ	JJ	_	7	amod	_	_
7	combinations	combination	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	retinoids	retinoid	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	1	1	CD	CD	_	16	nummod	_	_
12	alpha	alpha	NN	NN	_	16	compound	_	_
13	,	,	,	,	_	16	punct	_	_
14	25	25	CD	CD	_	16	nummod	_	_
15	dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	16	compound	_	_
16	D3	d3	NN	NN	_	9	conj	_	_
17	results	result	VBZ	VBZ	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	differentiation	differentiation	NN	NN	_	17	nmod	_	_
20	towards	towards	IN	IN	_	21	case	_	_
21	neutrophils	neutrophil	NNS	NNS	_	19	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	monocytes	monocyte	NNS	NNS	_	21	conj	_	_
24	or	or	CC	CC	_	19	cc	_	_
25	a	a	DT	DT	_	26	det	_	_
26	failure	failure	NN	NN	_	19	conj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	differentiate	differentiate	VB	VB	_	26	acl	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	apoptosis	apoptosis	NN	NN	_	26	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	well	well	RB	RB	_	4	advmod	_	_
4	documented	document	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	treatment	treatment	NN	NN	_	21	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	serum-grown	serum-grown	JJ	JJ	_	10	amod	_	_
9	HL60	hl60	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	10(-7)	10(-7)	CD	CD	_	13	nummod	_	_
13	M	m	NN	NN	_	6	nmod	_	_
14	all-trans	all-trans	JJ	JJ	_	16	amod	_	_
15	retinoic	retinoic	JJ	JJ	_	16	amod	_	_
16	acid	acid	NN	NN	_	13	dep	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	all-trans	all-trans	JJ	JJ	_	19	amod	_	_
19	RA	ra	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
22	neutrophil	neutrophil	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	21	punct	_	_
25	whereas	whereas	IN	IN	_	39	mark	_	_
26	treatment	treatment	NN	NN	_	39	nsubj	_	_
27	with	with	IN	IN	_	35	case	_	_
28	10(-7)	10(-7)	CD	CD	_	29	dep	_	_
29	M	m	NN	NN	_	35	dep	_	_
30	1	1	CD	CD	_	35	nummod	_	_
31	alpha	alpha	NN	NN	_	35	compound	_	_
32	,	,	,	,	_	35	punct	_	_
33	25	25	CD	CD	_	35	nummod	_	_
34	dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	35	compound	_	_
35	D3	d3	NN	NN	_	26	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	D3	d3	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	induces	induce	VBZ	VBZ	_	21	advcl	_	_
40	differentiation	differentiation	NN	NN	_	39	dobj	_	_
41	towards	towards	IN	IN	_	42	case	_	_
42	monocytes	monocyte	NNS	NNS	_	40	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	investigations	investigation	NNS	NNS	_	5	nmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	using	use	VBG	VBG	_	0	root	_	_
6	serum-free	serum-free	JJ	JJ	_	9	amod	_	_
7	grown	grown	JJ	JJ	_	9	amod	_	_
8	HL60	hl60	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	dobj	_	_
10	,	,	,	,	_	5	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	observed	observe	VBD	VBD	_	5	parataxis	_	_
13	that	that	IN	IN	_	23	mark	_	_
14	all-trans	all-trans	JJ	JJ	_	15	amod	_	_
15	RA	ra	NN	NN	_	23	nsubj	_	_
16	,	,	,	,	_	15	punct	_	_
17	at	at	IN	IN	_	19	case	_	_
18	10(-7)	10(-7)	CD	CD	_	19	nummod	_	_
19	M	m	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	did	do	VBD	VBD	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	induce	induce	VB	VB	_	12	ccomp	_	_
24	neutrophil	neutrophil	NN	NN	_	25	compound	_	_
25	differentiation	differentiation	NN	NN	_	23	dobj	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	that	that	IN	IN	_	35	mark	_	_
28	all-trans	all-trans	JJ	JJ	_	29	amod	_	_
29	RA	ra	NN	NN	_	35	nsubj	_	_
30	,	,	,	,	_	29	punct	_	_
31	at	at	IN	IN	_	33	case	_	_
32	10(-8)	10(-8)	CD	CD	_	33	nummod	_	_
33	M	m	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	29	punct	_	_
35	reduced	reduce	VBD	VBD	_	23	conj	_	_
36	the	the	DT	DT	_	38	det	_	_
37	D3	d3	NN	NN	_	38	compound	_	_
38	concentration	concentration	NN	NN	_	35	dobj	_	_
39	required	require	VBN	VBN	_	38	acl	_	_
40	for	for	IN	IN	_	42	case	_	_
41	monocyte	monocyte	NN	NN	_	42	compound	_	_
42	differentiation	differentiation	NN	NN	_	39	nmod	_	_
43	to	to	TO	TO	_	47	case	_	_
44	5	5	CD	CD	_	47	nummod	_	_
45	x	x	CC	CC	_	44	cc	_	_
46	10(-9)	10(-9)	CD	CD	_	44	conj	_	_
47	M	m	NN	NN	_	42	nmod	_	_
48	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	25	nmod	_	_
4	,	,	,	,	_	25	punct	_	_
5	co-operative	co-operative	JJ	JJ	_	6	amod	_	_
6	interactions	interaction	NNS	NNS	_	25	nsubjpass	_	_
7	between	between	IN	IN	_	8	case	_	_
8	all-trans	all-trans	JJ	JJ	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	9-cis	9-cis	JJ	JJ	_	8	conj	_	_
11	RA	ra	NN	NN	_	8	dep	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	D3	d3	NN	NN	_	8	conj	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	promote	promote	VBP	VBP	_	8	acl:relcl	_	_
16	neutrophil	neutrophil	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	19	cc	_	_
18	monocyte	monocyte	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	15	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	HL60	hl60	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	have	have	VBP	VBP	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	analysed	analyse	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	27	case	_	_
27	detail	detail	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	25	punct	_	_

1	Treatment	treatment	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	serum-free	serum-free	JJ	JJ	_	6	amod	_	_
4	grown	grown	JJ	JJ	_	6	amod	_	_
5	HL60	hl60	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	5	5	CD	CD	_	11	nummod	_	_
9	x	x	CC	CC	_	8	cc	_	_
10	10(-7)	10(-7)	CD	CD	_	8	conj	_	_
11	M	m	NN	NN	_	1	nmod	_	_
12	all-trans	all-trans	JJ	JJ	_	13	amod	_	_
13	RA	ra	NN	NN	_	11	dep	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	9-cis	9-cis	JJ	JJ	_	16	amod	_	_
16	RA	ra	NN	NN	_	13	conj	_	_
17	resulted	result	VBD	VBD	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	sub-optimal	sub-optimal	JJ	JJ	_	21	amod	_	_
20	neutrophil	neutrophil	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	28	punct	_	_
23	up	up	RB	RB	_	25	advmod	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	25	25	CD	CD	_	26	dep	_	_
26	%	%	NN	NN	_	28	dep	_	_
27	mature	mature	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	21	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	17	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	shown	show	VBN	VBN	_	9	advcl	_	_
3	for	for	IN	IN	_	5	case	_	_
4	all-trans	all-trans	JJ	JJ	_	5	amod	_	_
5	RA	ra	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	9-cis	9-cis	JJ	JJ	_	8	amod	_	_
8	RA	ra	NN	NN	_	9	nsubj	_	_
9	cooperated	cooperate	VBD	VBD	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	D3	d3	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	promote	promote	VB	VB	_	9	xcomp	_	_
14	monocyte	monocyte	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	9	punct	_	_

1	Culture	culture	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HL60	hl60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	11	case	_	_
6	5	5	CD	CD	_	9	dep	_	_
7	x	x	CC	CC	_	6	cc	_	_
8	10(-7)	10(-7)	CD	CD	_	6	conj	_	_
9	M	m	NN	NN	_	11	dep	_	_
10	9-cis	9-cis	JJ	JJ	_	11	amod	_	_
11	RA	ra	NN	NN	_	1	nmod	_	_
12	together	together	RB	RB	_	1	advmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	wide	wide	JJ	JJ	_	16	amod	_	_
16	range	range	NN	NN	_	1	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	concentrations	concentration	NNS	NNS	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	D3	d3	NN	NN	_	18	nmod	_	_
21	resulted	result	VBD	VBD	_	0	root	_	_
22	in	in	IN	IN	_	23	case	_	_
23	promotion	promotion	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	neutrophil	neutrophil	NN	NN	_	26	compound	_	_
26	differentiation	differentiation	NN	NN	_	23	nmod	_	_
27	at	at	IN	IN	_	29	case	_	_
28	10(-15)-10(-12)	10(-15)-10(-12)	CD	CD	_	29	nummod	_	_
29	D3	d3	NN	NN	_	23	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	a	a	DT	DT	_	32	det	_	_
32	failure	failure	NN	NN	_	23	appos	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	differentiate	differentiate	VB	VB	_	32	acl	_	_
35	and	and	CC	CC	_	32	cc	_	_
36	apoptosis	apoptosis	NN	NN	_	32	conj	_	_
37	at	at	IN	IN	_	40	case	_	_
38	10(-11)-10(-10)	10(-11)-10(-10)	CD	CD	_	39	dep	_	_
39	M	m	NN	NN	_	40	dep	_	_
40	D3	d3	NN	NN	_	32	nmod	_	_
41	,	,	,	,	_	21	punct	_	_
42	followed	follow	VBN	VBN	_	21	dep	_	_
43	by	by	IN	IN	_	44	case	_	_
44	co-operativity	co-operativity	NN	NN	_	42	nmod	_	_
45	between	between	IN	IN	_	47	case	_	_
46	9-cis	9-cis	JJ	JJ	_	47	amod	_	_
47	RA	ra	NN	NN	_	44	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	5	5	CD	CD	_	52	dep	_	_
50	x	x	CC	CC	_	49	cc	_	_
51	10(-9)	10(-9)	CD	CD	_	49	conj	_	_
52	M	m	NN	NN	_	53	dep	_	_
53	D3	d3	NN	NN	_	47	conj	_	_
54	in	in	IN	IN	_	55	mark	_	_
55	inducing	induce	VBG	VBG	_	44	acl	_	_
56	monocyte	monocyte	NN	NN	_	57	compound	_	_
57	differentiation	differentiation	NN	NN	_	55	dobj	_	_
58	in	in	IN	IN	_	60	case	_	_
59	the	the	DT	DT	_	60	det	_	_
60	absence	absence	NN	NN	_	55	nmod	_	_
61	of	of	IN	IN	_	63	case	_	_
62	neutrophil	neutrophil	NN	NN	_	63	compound	_	_
63	differentiation	differentiation	NN	NN	_	60	nmod	_	_
64	.	.	.	.	_	21	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	when	when	WRB	WRB	_	9	advmod	_	_
6	HL60	hl60	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	treated	treat	VBN	VBN	_	4	advcl	_	_
10	with	with	IN	IN	_	15	case	_	_
11	5	5	CD	CD	_	15	nummod	_	_
12	x	x	CC	CC	_	11	cc	_	_
13	10(-7)	10(-7)	CD	CD	_	11	conj	_	_
14	all-trans	all-trans	JJ	JJ	_	15	amod	_	_
15	RA	ra	NN	NN	_	9	nmod	_	_
16	together	together	RB	RB	_	20	advmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	wide	wide	JJ	JJ	_	20	amod	_	_
20	range	range	NN	NN	_	9	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	concentrations	concentration	NNS	NNS	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	D3	d3	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Cross	cross	NN	NN	_	3	compound	_	_
2	titration	titration	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	9-cis	9-cis	JJ	JJ	_	9	amod	_	_
9	RA	ra	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	D3	d3	NN	NN	_	9	conj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	HL60	hl60	NN	NN	_	14	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	differentiation	differentiation	NN	NN	_	6	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	undertaken	undertake	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	determine	determine	VB	VB	_	17	xcomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	boundaries	boundary	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	concentrations	concentration	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	each	each	DT	DT	_	27	det	_	_
27	agent	agent	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	alone	alone	RB	RB	_	30	advmod	_	_
30	and	and	CC	CC	_	27	advmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	combination	combination	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	24	punct	_	_
34	that	that	WDT	WDT	_	35	nsubj	_	_
35	give	give	VBP	VBP	_	24	acl:relcl	_	_
36	rise	rise	NN	NN	_	35	dobj	_	_
37	to	to	TO	TO	_	39	case	_	_
38	optimal	optimal	JJ	JJ	_	39	amod	_	_
39	neutrophil	neutrophil	NN	NN	_	35	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	monocyte	monocyte	NN	NN	_	39	conj	_	_
42	differentiation	differentiation	NN	NN	_	39	dep	_	_
43	of	of	IN	IN	_	45	case	_	_
44	HL60	hl60	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	39	nmod	_	_
46	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	observed	observe	VBN	VBN	_	3	amod	_	_
3	cooperativities	cooperativity	NNS	NNS	_	13	nsubj	_	_
4	between	between	IN	IN	_	7	case	_	_
5	either	either	CC	CC	_	7	cc:preconj	_	_
6	9-cis	9-cis	JJ	JJ	_	7	amod	_	_
7	RA	ra	NN	NN	_	3	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	all-trans	all-trans	JJ	JJ	_	10	amod	_	_
10	RA	ra	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	D3	d3	NN	NN	_	7	conj	_	_
13	have	have	VBP	VBP	_	0	root	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	implications	implication	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	use	use	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	combinations	combination	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	agents	agent	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	differentiation	differentiation	NN	NN	_	26	compound	_	_
26	therapy	therapy	NN	NN	_	13	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-ATc	nf-atc	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	NF-ATp	nf-atp	NN	NN	_	5	conj	_	_
8	:	:	:	:	_	1	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
11	components	component	NNS	NNS	_	1	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-AT	nf-at	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	11	punct	_	_

1	Present	present	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	pathway	pathway	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transmission	transmission	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	outlined	outline	VBN	VBN	_	5	acl:relcl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	figure	figure	NN	NN	_	14	nmod	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	elevation	elevation	NN	NN	_	15	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
5	calcium	calcium	NN	NN	_	2	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	2	acl:relcl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	interactions	interaction	NNS	NNS	_	8	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	antigen	antigen	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	leads	lead	VBZ	VBZ	_	0	root	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	calcium-dependent	calcium-dependent	JJ	JJ	_	23	amod	_	_
22	phosphatase	phosphatase	NN	NN	_	23	compound	_	_
23	calcineurin	calcineurin	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	in	in	IN	IN	_	3	case	_	_
3	turn	turn	NN	NN	_	4	nmod	_	_
4	leads	lead	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	association	association	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cytosolic	cytosolic	JJ	JJ	_	12	amod	_	_
12	component	component	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-ATc	nf-atc	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	calcineurin	calcineurin	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	import	import	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-ATc	nf-atc	NN	NN	_	8	nmod	_	_
11	can	can	MD	MD	_	14	aux	_	_
12	both	both	DT	DT	_	14	advmod	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	FK506	fk506	NN	NN	_	17	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	complex	complex	NN	NN	_	17	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	respective	respective	JJ	JJ	_	25	amod	_	_
25	immunophilins	immunophilin	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	Once	once	RB	RB	_	4	advmod	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	nucleus	nucleus	NN	NN	_	7	advcl	_	_
5	,	,	,	,	_	7	punct	_	_
6	NF-ATc	nf-atc	NN	NN	_	7	nsubj	_	_
7	interacts	interact	VBZ	VBZ	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	NF-ATn	nf-atn	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	form	form	VB	VB	_	7	xcomp	_	_
12	an	a	DT	DT	_	15	det	_	_
13	active	active	JJ	JJ	_	15	amod	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	complex	complex	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	NF-ATn	nf-atn	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	ubiquitous	ubiquitous	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	synthesized	synthesize	VBN	VBN	_	5	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	response	response	NN	NN	_	13	dep	_	_
12	to	to	TO	TO	_	13	case	_	_
13	PMA	pma	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	has	have	VBZ	VBZ	_	5	conj	_	_
17	many	many	JJ	JJ	_	18	amod	_	_
18	similarities	similarity	NNS	NNS	_	16	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	AP-1	ap-1	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	10	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	NF-ATc	nf-atc	NN	NN	_	6	nsubj	_	_
6	enters	enter	VBZ	VBZ	_	2	acl:relcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nucleus	nucleus	NN	NN	_	6	dobj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	unknown	unknown	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	although	although	IN	IN	_	15	mark	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	appears	appear	VBZ	VBZ	_	25	advcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	require	require	VB	VB	_	15	xcomp	_	_
18	calcineurin	calcineurin	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	25	punct	_	_
20	NF-ATc	nf-atc	NN	NN	_	25	nsubjpass	_	_
21	has	have	VBZ	VBZ	_	25	aux	_	_
22	not	not	RB	RB	_	25	neg	_	_
23	yet	yet	RB	RB	_	25	advmod	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	shown	show	VBN	VBN	_	10	conj	_	_
26	to	to	TO	TO	_	31	mark	_	_
27	be	be	VB	VB	_	31	cop	_	_
28	an	a	DT	DT	_	31	det	_	_
29	in	in	FW	FW	_	31	amod	_	_
30	vivo	vivo	FW	FW	_	29	dep	_	_
31	substrate	substrate	NN	NN	_	25	xcomp	_	_
32	of	of	IN	IN	_	33	case	_	_
33	calcineurin	calcineurin	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	3	nsubj	_	_
3	include	include	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	NF-ATc	nf-atc	NN	NN	_	8	nsubj	_	_
8	operates	operate	VBZ	VBZ	_	5	ccomp	_	_
9	on	on	IN	IN	_	12	case	_	_
10	some	some	DT	DT	_	12	det	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
12	anchor	anchor	NN	NN	_	8	nmod	_	_
13	or	or	CC	CC	_	8	cc	_	_
14	that	that	IN	IN	_	22	mark	_	_
15	other	other	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	22	nsubj	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	controlled	control	VBN	VBN	_	16	acl:relcl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	calcineurin	calcineurin	NN	NN	_	19	nmod	_	_
22	carry	carry	VBP	VBP	_	8	conj	_	_
23	out	out	RP	RP	_	22	compound:prt	_	_
24	the	the	DT	DT	_	26	det	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	import	import	NN	NN	_	22	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	NF-ATc	nf-atc	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	NF-ATp	nf-atp	NN	NN	_	3	nsubj	_	_
3	copurifies	copurify	VBZ	VBZ	_	8	advcl	_	_
4	with	with	IN	IN	_	5	case	_	_
5	NF-ATc	nf-atc	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	as	as	RB	RB	_	10	advmod	_	_
10	yet	yet	RB	RB	_	8	advmod	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	understanding	understanding	NN	NN	_	8	nsubj	_	_
13	of	of	IN	IN	_	17	mark	_	_
14	how	how	WRB	WRB	_	17	advmod	_	_
15	NF-ATp	nf-atp	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	aux	_	_
17	functioning	function	VBG	VBG	_	12	acl	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vivo	vivo	FW	FW	_	17	advmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Now	now	RB	RB	_	6	advmod	_	_
2	that	that	IN	IN	_	6	mark	_	_
3	these	these	DT	DT	_	4	det	_	_
4	proteins	protein	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	purified	purify	VBN	VBN	_	14	advcl	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	cloned	clone	VBN	VBN	_	6	conj	_	_
9	,	,	,	,	_	14	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	major	major	JJ	JJ	_	12	amod	_	_
12	goals	goal	NNS	NNS	_	14	nsubj	_	_
13	will	will	MD	MD	_	14	aux	_	_
14	be	be	VB	VB	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	understand	understand	VB	VB	_	14	xcomp	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	role	role	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	roles	role	NNS	NNS	_	18	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	other	other	JJ	JJ	_	25	amod	_	_
24	family	family	NN	NN	_	25	compound	_	_
25	members	member	NNS	NNS	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	thymic	thymic	JJ	JJ	_	28	amod	_	_
28	development	development	NN	NN	_	18	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HIV	hiv	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	2	nmod	_	_
8	correlates	correlate	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	retinoic	retinoic	JJ	JJ	_	16	amod	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	OBJECTIVES	objective	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	analyze	analyze	VB	VB	_	1	acl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	retinoic	retinoic	JJ	JJ	_	9	amod	_	_
9	acids	acid	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	RA	ra	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	on	on	IN	IN	_	15	case	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	6	nmod	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	correlate	correlate	VB	VB	_	4	conj	_	_
18	this	this	DT	DT	_	19	det	_	_
19	effect	effect	NN	NN	_	17	dobj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	levels	level	NNS	NNS	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	RA	ra	NN	NN	_	25	compound	_	_
25	receptors	receptor	NNS	NNS	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	RARs	rar	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	in	in	IN	IN	_	30	case	_	_
30	T-lymphoid	t-lymphoid	JJ	JJ	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	monocytoid	monocytoid	JJ	JJ	_	30	conj	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	30	dep	_	_
35	.	.	.	.	_	4	punct	_	_

1	DESIGN	design	NN	NN	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	The	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	32	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	all-trans	all-trans	JJ	JJ	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	9-cis	9-cis	JJ	JJ	_	8	conj	_	_
11	RA	ra	NN	NN	_	8	dep	_	_
12	on	on	IN	IN	_	14	case	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	6	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	T-lymphoid	t-lymphoid	JJ	JJ	_	6	nmod	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	H9	h9	NN	NN	_	20	compound	_	_
19	,	,	,	,	_	20	punct	_	_
20	CEM	cem	NN	NN	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	monocytoid	monocytoid	JJ	JJ	_	30	amod	_	_
24	(	(	-LRB-	-LRB-	_	30	punct	_	_
25	U937	u937	NN	NN	_	30	compound	_	_
26	,	,	,	,	_	30	punct	_	_
27	THP-1	thp-1	NN	NN	_	30	dep	_	_
28	)	)	-RRB-	-RRB-	_	30	punct	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	16	conj	_	_
31	was	be	VBD	VBD	_	32	auxpass	_	_
32	measured	measure	VBN	VBN	_	1	dep	_	_
33	during	during	IN	IN	_	34	case	_	_
34	acute	acute	JJ	JJ	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	chronic	chronic	JJ	JJ	_	34	conj	_	_
37	infection	infection	NN	NN	_	34	dep	_	_
38	.	.	.	.	_	32	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	32	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	RAR	rar	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	hRAR	hrar	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	,	,	,	,	_	12	punct	_	_
12	receptor	receptor	NN	NN	_	7	dep	_	_
13	for	for	IN	IN	_	15	case	_	_
14	all-trans	all-trans	JJ	JJ	_	15	amod	_	_
15	RA	ra	NN	NN	_	12	nmod	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	the	the	DT	DT	_	22	det	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	retinoid-X	retinoid-x	NN	NN	_	22	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	7	conj	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	hRXR	hrxr	NN	NN	_	26	compound	_	_
25	alpha	alpha	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	22	dep	_	_
27	for	for	IN	IN	_	29	case	_	_
28	9-cis	9-cis	JJ	JJ	_	29	amod	_	_
29	RA	ra	NN	NN	_	26	nmod	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	determined	determine	VBN	VBN	_	0	root	_	_
33	by	by	IN	IN	_	36	case	_	_
34	Northern	northern	NN	NN	_	36	compound	_	_
35	blot	blot	NN	NN	_	36	compound	_	_
36	analysis	analysis	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	32	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Both	both	CC	CC	_	4	cc:preconj	_	_
4	all-trans	all-trans	JJ	JJ	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	9-cis	9-cis	JJ	JJ	_	4	conj	_	_
7	RA	ra	NN	NN	_	4	dep	_	_
8	inhibited	inhibit	VBD	VBD	_	1	dep	_	_
9	virus	virus	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
13	IIIB-infected	iiib-infected	JJ	JJ	_	15	amod	_	_
14	monocytoid	monocytoid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	presence	presence	NN	NN	_	8	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	absence	absence	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	co-stimulatory	co-stimulatory	JJ	JJ	_	25	amod	_	_
25	agent	agent	NN	NN	_	19	nmod	_	_
26	phorbol	phorbol	NN	NN	_	28	compound	_	_
27	myristate	myristate	NN	NN	_	28	compound	_	_
28	acetate	acetate	NN	NN	_	25	dep	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PMA	pma	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	retinoids	retinoid	NNS	NNS	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	weak	weak	JJ	JJ	_	3	dobj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	no	no	DT	DT	_	4	conj	_	_
7	stimulatory	stimulatory	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	4	dep	_	_
9	on	on	IN	IN	_	11	case	_	_
10	HIV	hiv	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	3	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	HIV	hiv	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	8	nsubjpass	_	_
3	by	by	IN	IN	_	6	case	_	_
4	PMA-stimulated	pma-stimulated	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	retinoids	retinoid	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	9-cis	9-cis	JJ	JJ	_	3	amod	_	_
3	RA	ra	NN	NN	_	7	nsubj	_	_
4	was	be	VBD	VBD	_	7	cop	_	_
5	generally	generally	RB	RB	_	7	advmod	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	effective	effective	JJ	JJ	_	0	root	_	_
8	than	than	IN	IN	_	10	case	_	_
9	all-trans	all-trans	JJ	JJ	_	10	amod	_	_
10	RA	ra	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	inhibiting	inhibit	VBG	VBG	_	7	advcl	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	in	in	IN	IN	_	17	case	_	_
17	combination	combination	NN	NN	_	7	conj	_	_
18	generally	generally	RB	RB	_	20	advmod	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	effective	effective	JJ	JJ	_	7	dep	_	_
21	than	than	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	single	single	JJ	JJ	_	24	amod	_	_
24	agents	agent	NNS	NNS	_	20	nmod	_	_
25	alone	alone	RB	RB	_	24	advmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	RAR	rar	NN	NN	_	3	compound	_	_
3	alpha	alpha	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	H9	h9	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	U937	u937	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	THP-1	thp-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	but	but	CC	CC	_	5	cc	_	_
15	almost	almost	RB	RB	_	16	advmod	_	_
16	undetectable	undetectable	JJ	JJ	_	5	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	CEM	cem	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	RXR	rxr	NN	NN	_	3	compound	_	_
3	alpha	alpha	NN	NN	_	4	nsubj	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	significantly	significantly	RB	RB	_	14	advmod	_	_
6	expressed	express	VBN	VBN	_	14	dep	_	_
7	in	in	IN	IN	_	8	case	_	_
8	U937	u937	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	THP-1	thp-1	NN	NN	_	8	conj	_	_
11	cells	cell	NNS	NNS	_	8	dep	_	_
12	,	,	,	,	_	14	punct	_	_
13	weakly	weakly	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	4	advmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	H9	h9	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	not	not	RB	RB	_	14	conj	_	_
20	detectable	detectable	JJ	JJ	_	14	dep	_	_
21	in	in	IN	IN	_	23	case	_	_
22	CEM	cem	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	9	nmod	_	_
3	by	by	IN	IN	_	4	case	_	_
4	PMA	pma	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	RXR	rxr	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	9	nsubj	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	H9	h9	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	U937	u937	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	but	but	CC	CC	_	11	cc	_	_
16	not	not	RB	RB	_	19	neg	_	_
17	in	in	IN	IN	_	19	case	_	_
18	CEM	cem	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	RAR	rar	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	unchanged	unchanged	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	H9	h9	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CEM	cem	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	elevated	elevate	VBD	VBD	_	6	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	U937	u937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	after	after	IN	IN	_	21	case	_	_
20	PMA	pma	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	RA	ra	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	cell-type-dependent	cell-type-dependent	JJ	JJ	_	1	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	partially	partially	RB	RB	_	11	advmod	_	_
14	correlated	correlate	VBN	VBN	_	11	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	RARs	rar	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Endogenous	endogenous	JJ	JJ	_	7	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	exogenously	exogenously	RB	RB	_	1	conj	_	_
4	administered	administer	VBN	VBN	_	3	amod	_	_
5	RA	ra	NN	NN	_	1	dep	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	have	have	VB	VB	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HIV	hiv	NN	NN	_	13	compound	_	_
13	regulation	regulation	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Interleukin-5	interleukin-5	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	eosinophils	eosinophil	NNS	NNS	_	2	nmod	_	_
6	involves	involve	VBZ	VBZ	_	0	root	_	_
7	JAK2	jak2	NN	NN	_	9	compound	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Stat1	stat1	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	6	punct	_	_

1	Signaling	signaling	NN	NN	_	18	nsubj	_	_
2	by	by	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	wide	wide	JJ	JJ	_	5	amod	_	_
5	variety	variety	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	including	include	VBG	VBG	_	10	case	_	_
10	interferons	interferon	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	interleukins	interleukin	NNS	NNS	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	growth	growth	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	10	conj	_	_
17	,	,	,	,	_	1	punct	_	_
18	involves	involve	VBZ	VBZ	_	0	root	_	_
19	activation	activation	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	JAK	jak	NN	NN	_	22	compound	_	_
22	kinases	kinase	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Stat	stat	NNS	NNS	_	27	compound	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	Signal	signal	NN	NN	_	27	compound	_	_
27	transducers	transducer	NNS	NNS	_	22	conj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	activators	activator	NNS	NNS	_	33	compound	_	_
30	of	of	IN	IN	_	33	amod	_	_
31	transcription	transcription	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	proteins	protein	NNS	NNS	_	27	conj	_	_
34	.	.	.	.	_	18	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	present	present	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	much	much	RB	RB	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	about	about	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	7	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	which	which	WDT	WDT	_	18	nmod	_	_
14	interleukin-5	interleukin-5	NN	NN	_	18	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-5	il-5	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	exerts	exert	VBZ	VBZ	_	11	acl:relcl	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	diverse	diverse	JJ	JJ	_	22	amod	_	_
21	biologic	biologic	JJ	JJ	_	20	dep	_	_
22	effects	effect	NNS	NNS	_	18	dobj	_	_
23	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	eosinophils	eosinophil	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	one	one	CD	CD	_	0	root	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	most	most	RBS	RBS	_	8	advmod	_	_
8	important	important	JJ	JJ	_	10	amod	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	IL-5	il-5	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	used	use	VBN	VBN	_	4	conj	_	_
16	here	here	RB	RB	_	15	advmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	study	study	VB	VB	_	15	xcomp	_	_
19	IL-5	il-5	NN	NN	_	20	compound	_	_
20	signaling	signaling	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	primary	primary	JJ	JJ	_	25	amod	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	cell	cell	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	IL-5	il-5	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	rapid	rapid	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	transient	transient	JJ	JJ	_	3	conj	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	JAK2	jak2	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-5	il-5	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	at	at	IN	IN	_	6	case	_	_
6	least	least	JJS	JJS	_	7	nmod:npmod	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	4	dobj	_	_
10	,	,	,	,	_	4	punct	_	_
11	using	use	VBG	VBG	_	4	advcl	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	11	dobj	_	_
14	from	from	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	eosinophils	eosinophil	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	IL-6/interferon-gamma	il-6/interferon-gamma	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	17	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	ICAM-1	icam-1	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	ICAM-1	icam-1	NN	NN	_	29	compound	_	_
29	pIRE	pire	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	in	in	IN	IN	_	35	case	_	_
32	an	a	DT	DT	_	35	det	_	_
33	electromobility	electromobility	NN	NN	_	35	compound	_	_
34	shift	shift	NN	NN	_	35	compound	_	_
35	assay	assay	NN	NN	_	11	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	supershift	supershift	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	6	nmod	_	_
4	it	it	PRP	PRP	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	concluded	conclude	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	one	one	CD	CD	_	10	nummod	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	11	nsubj	_	_
11	contained	contain	VBD	VBD	_	6	ccomp	_	_
12	Stat1	stat1	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	11	punct	_	_
15	probably	probably	RB	RB	_	18	advmod	_	_
16	as	as	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	homodimer	homodimer	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Both	both	DT	DT	_	3	dep	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	complexes	complex	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	phosphotyrosine	phosphotyrosine	NN	NN	_	9	compound	_	_
9	antibody	antibody	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	4G10	4g10	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	5	punct	_	_
14	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphorylation	phosphorylation	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	14	ccomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	complex	complex	NN	NN	_	22	compound	_	_
22	formation	formation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	IL-3	il-3	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	5	amod	_	_
4	colony-stimulating	colony-stimulating	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	1	conj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	similar	similar	JJ	JJ	_	6	xcomp	_	_
9	to	to	TO	TO	_	10	case	_	_
10	IL-5	il-5	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	6	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	eosinophils	eosinophil	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	including	include	VBG	VBG	_	21	case	_	_
20	Stat1	stat1	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	17	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	IL-5	il-5	NN	NN	_	13	compound	_	_
13	signaling	signaling	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	eosinophils	eosinophil	NNS	NNS	_	13	nmod	_	_
17	involve	involve	VBP	VBP	_	3	ccomp	_	_
18	members	member	NNS	NNS	_	17	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	JAK	jak	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	family	family	NN	NN	_	18	nmod	_	_
24	as	as	RB	RB	_	18	cc	_	_
25	well	well	RB	RB	_	24	mwe	_	_
26	as	as	IN	IN	_	24	mwe	_	_
27	members	member	NNS	NNS	_	18	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	Stat	stat	NN	NN	_	31	compound	_	_
31	family	family	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	TR2	tr2	NN	NN	_	8	compound	_	_
5	orphan	orphan	NN	NN	_	8	compound	_	_
6	receptor	receptor	NN	NN	_	8	compound	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
12	initiation	initiation	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	simian	simian	JJ	JJ	_	21	amod	_	_
17	virus	virus	NN	NN	_	21	compound	_	_
18	40	40	CD	CD	_	21	nummod	_	_
19	major	major	JJ	JJ	_	21	amod	_	_
20	late	late	JJ	JJ	_	21	amod	_	_
21	promoter	promoter	NN	NN	_	13	nmod	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	25	punct	_	_
23	published	publish	VBN	VBN	_	24	amod	_	_
24	erratum	erratum	NN	NN	_	25	nsubj	_	_
25	appears	appear	VBZ	VBZ	_	1	dep	_	_
26	in	in	IN	IN	_	31	case	_	_
27	J	J	NNP	NNP	_	31	compound	_	_
28	Biol	Biol	NNP	NNP	_	31	compound	_	_
29	Chem	Chem	NNP	NNP	_	31	compound	_	_
30	1995	1995	CD	CD	_	31	nummod	_	_
31	Nov	Nov	NNP	NNP	_	25	nmod	_	_
32	3	3	CD	CD	_	31	nummod	_	_
33	;	;	:	:	_	31	punct	_	_
34	270	270	CD	CD	_	36	nummod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	44	44	CD	CD	_	31	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	:	:	:	:	_	31	punct	_	_
39	26721	26721	CD	CD	_	31	dep	_	_
40	-RSB-	-rsb-	-RRB-	-RRB-	_	25	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	response	response	NN	NN	_	4	compound	_	_
4	element	element	NN	NN	_	25	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TR2RE-SV40	tr2re-sv40	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	for	for	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	TR2	tr2	NN	NN	_	12	compound	_	_
11	orphan	orphan	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	15	det	_	_
15	member	member	NN	NN	_	12	appos	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	steroid-thyroid	steroid-thyroid	JJ	JJ	_	21	amod	_	_
19	hormone	hormone	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	superfamily	superfamily	NN	NN	_	15	nmod	_	_
22	,	,	,	,	_	4	punct	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	identified	identify	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	35	case	_	_
27	the	the	DT	DT	_	35	det	_	_
28	simian	simian	JJ	JJ	_	35	amod	_	_
29	virus	virus	NN	NN	_	35	compound	_	_
30	40	40	CD	CD	_	35	nummod	_	_
31	(	(	-LRB-	-LRB-	_	35	punct	_	_
32	SV40	sv40	NN	NN	_	35	compound	_	_
33	)	)	-RRB-	-RRB-	_	35	punct	_	_
34	+55	+55	CD	CD	_	35	nummod	_	_
35	region	region	NN	NN	_	25	nmod	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	nucleotide	nucleotide	NN	NN	_	38	compound	_	_
38	numbers	number	NNS	NNS	_	35	dep	_	_
39	368-389	368-389	CD	CD	_	38	nummod	_	_
40	,	,	,	,	_	38	punct	_	_
41	5'-GTTAAGGTTCGTAGGTCATGGA-3'	5'-gttaaggttcgtaggtcatgga-3'	NN	NN	_	38	appos	_	_
42	)	)	-RRB-	-RRB-	_	38	punct	_	_
43	.	.	.	.	_	25	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	21	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	using	use	VBG	VBG	_	21	dep	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	12	advmod	_	_
9	translated	translate	VBN	VBN	_	12	amod	_	_
10	TR2	tr2	NN	NN	_	12	compound	_	_
11	orphan	orphan	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	6	dobj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	mass	mass	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	67	67	CD	CD	_	19	nummod	_	_
19	kilodaltons	kilodalton	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	21	punct	_	_
21	showed	show	VBD	VBD	_	0	root	_	_
22	a	a	DT	DT	_	24	det	_	_
23	specific	specific	JJ	JJ	_	24	amod	_	_
24	binding	binding	NN	NN	_	21	dobj	_	_
25	with	with	IN	IN	_	27	case	_	_
26	high	high	JJ	JJ	_	27	amod	_	_
27	affinity	affinity	NN	NN	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	dissociation	dissociation	NN	NN	_	30	compound	_	_
30	constant	constant	NN	NN	_	27	dep	_	_
31	=	=	JJ	JJ	_	30	amod	_	_
32	9	9	CD	CD	_	33	nummod	_	_
33	nM	nm	NN	NN	_	31	dep	_	_
34	)	)	-RRB-	-RRB-	_	30	punct	_	_
35	for	for	IN	IN	_	38	case	_	_
36	this	this	DT	DT	_	38	det	_	_
37	DNA	dna	NN	NN	_	38	compound	_	_
38	sequence	sequence	NN	NN	_	24	nmod	_	_
39	.	.	.	.	_	21	punct	_	_

1	DNA-swap	dna-swap	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	chloramphenicol	chloramphenicol	NN	NN	_	5	compound	_	_
5	acetyl-transferase	acetyl-transferase	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	3	dobj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	androgen	androgen	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	suppress	suppress	VB	VB	_	7	ccomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activities	activity	NNS	NNS	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	SV40	sv40	NN	NN	_	18	compound	_	_
17	early	early	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	via	via	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	interaction	interaction	NN	NN	_	11	nmod	_	_
22	between	between	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	TR2RE-SV40	tr2re-sv40	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	29	det	_	_
27	chimeric	chimeric	JJ	JJ	_	29	amod	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	AR/TR2/AR	ar/tr2/ar	NN	NN	_	24	conj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	DNA-binding	dna-binding	JJ	JJ	_	33	amod	_	_
33	domain	domain	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	TR2	tr2	NN	NN	_	38	compound	_	_
37	orphan	orphan	NN	NN	_	38	compound	_	_
38	receptor	receptor	NN	NN	_	33	nmod	_	_
39	flanked	flank	VBN	VBN	_	33	acl	_	_
40	by	by	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	dep	_	_
42	N-terminal	n-terminal	JJ	JJ	_	39	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	androgen-binding	androgen-binding	JJ	JJ	_	42	conj	_	_
45	domains	domain	NNS	NNS	_	42	dep	_	_
46	of	of	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	androgen	androgen	NN	NN	_	49	compound	_	_
49	receptor	receptor	NN	NN	_	42	nmod	_	_
50	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	TR2RE-SV40	tr2re-sv40	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	function	function	VB	VB	_	0	root	_	_
8	as	as	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	repressor	repressor	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	suppress	suppress	VB	VB	_	10	acl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activities	activity	NNS	NNS	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	SV40	sv40	NN	NN	_	15	nmod	_	_
19	early	early	JJ	JJ	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	late	late	JJ	JJ	_	18	conj	_	_
22	promoters	promoter	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	7	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	TR2RE-SV40	tr2re-sv40	NN	NN	_	5	dobj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	represent	represent	VB	VB	_	5	dep	_	_
10	the	the	DT	DT	_	16	det	_	_
11	first	first	JJ	JJ	_	16	amod	_	_
12	identified	identify	VBN	VBN	_	16	amod	_	_
13	natural	natural	JJ	JJ	_	16	amod	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	9	dobj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	TR2	tr2	NN	NN	_	21	compound	_	_
20	orphan	orphan	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	function	function	VB	VB	_	16	acl:relcl	_	_
25	as	as	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	repressor	repressor	NN	NN	_	24	nmod	_	_
28	for	for	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	SV40	sv40	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Mapping	mapping	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	interaction	interaction	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	defective	defective	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	21	case	_	_
12	the	the	DT	DT	_	21	det	_	_
13	class	class	NN	NN	_	21	compound	_	_
14	II	ii	CD	CD	_	21	nummod	_	_
15	major	major	JJ	JJ	_	21	amod	_	_
16	histocompatibility	histocompatibility	NN	NN	_	21	compound	_	_
17	complex	complex	NN	NN	_	21	compound	_	_
18	mutant	mutant	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	line	line	NN	NN	_	21	compound	_	_
21	clone-13	clone-13	NN	NN	_	5	nmod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	divergent	divergent	JJ	JJ	_	25	amod	_	_
25	X2-box	x2-box	NN	NN	_	1	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	described	describe	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	10	det	_	_
6	mutant	mutant	JJ	JJ	_	10	amod	_	_
7	B	b	NN	NN	_	10	compound	_	_
8	lymphoblastoid	lymphoblastoid	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	4	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	Clone-13	clone-13	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	12	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	expresses	express	VBZ	VBZ	_	10	acl:relcl	_	_
16	HLA-DQ	hla-dq	NN	NN	_	15	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	absence	absence	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	HLA-DR	hla-dr	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	-DP	-dp	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	criteria	criterion	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	defect	defect	NN	NN	_	11	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	this	this	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	6	nmod	_	_
11	influences	influence	VBZ	VBZ	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	isotype-specific	isotype-specific	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Indeed	indeed	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	transient	transient	JJ	JJ	_	4	amod	_	_
4	transfection	transfection	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HLA-DRA	hla-dra	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	DQB	dqb	NN	NN	_	6	conj	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	constructs	construct	NNS	NNS	_	6	dep	_	_
11	indicated	indicate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	affected	affect	VBN	VBN	_	15	amod	_	_
15	factor	factor	NN	NN	_	16	nsubj	_	_
16	operates	operate	VBZ	VBZ	_	11	ccomp	_	_
17	via	via	IN	IN	_	18	case	_	_
18	cis-elements	cis-element	NNS	NNS	_	16	nmod	_	_
19	located	located	JJ	JJ	_	18	amod	_	_
20	between	between	IN	IN	_	23	case	_	_
21	-141	-141	CD	CD	_	23	nummod	_	_
22	base	base	NN	NN	_	23	compound	_	_
23	pairs	pair	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	28	det	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	initiation	initiation	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	series	series	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	hybrid	hybrid	NN	NN	_	7	compound	_	_
5	DRA/DQB	dra/dqb	NN	NN	_	7	compound	_	_
6	reporter	reporter	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	generated	generate	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	further	further	JJ	JJ	_	9	nmod	_	_
12	map	map	VB	VB	_	11	dep	_	_
13	the	the	DT	DT	_	15	det	_	_
14	relevant	relevant	JJ	JJ	_	15	amod	_	_
15	cis-elements	cis-element	NNS	NNS	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	system	system	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Insertion	insertion	NN	NN	_	27	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	oligonucleotides	oligonucleotide	NNS	NNS	_	1	nmod	_	_
4	spanning	span	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DQB	dqb	NN	NN	_	7	compound	_	_
7	X-box	x-box	NN	NN	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	13	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DQB-W	dqb-w	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	7	dep	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	DQB	dqb	NN	NN	_	17	compound	_	_
17	Y-box	y-box	NN	NN	_	13	conj	_	_
18	)	)	-RRB-	-RRB-	_	13	punct	_	_
19	upstream	upstream	JJ	JJ	_	21	amod	_	_
20	of	of	IN	IN	_	21	amod	_	_
21	-141	-141	CD	CD	_	7	dep	_	_
22	in	in	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	DRA	dra	NN	NN	_	26	compound	_	_
25	reporter	reporter	NN	NN	_	26	compound	_	_
26	plasmid	plasmid	NN	NN	_	4	nmod	_	_
27	rescued	rescue	VBD	VBD	_	0	root	_	_
28	expression	expression	NN	NN	_	27	dobj	_	_
29	to	to	TO	TO	_	32	case	_	_
30	nearly	nearly	RB	RB	_	31	advmod	_	_
31	wild-type	wild-type	JJ	JJ	_	32	amod	_	_
32	levels	level	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	27	punct	_	_

1	Substitution	substitution	NN	NN	_	2	compound	_	_
2	promoters	promoter	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	then	then	RB	RB	_	5	advmod	_	_
5	generated	generate	VBN	VBN	_	0	root	_	_
6	where	where	WRB	WRB	_	20	advmod	_	_
7	the	the	DT	DT	_	9	det	_	_
8	entire	entire	JJ	JJ	_	9	amod	_	_
9	X-box	x-box	NN	NN	_	20	nsubjpass	_	_
10	,	,	,	,	_	9	punct	_	_
11	or	or	CC	CC	_	9	cc	_	_
12	only	only	RB	RB	_	14	advmod	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	X1-	x1-	NN	NN	_	9	conj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	X2-boxes	x2-box	NNS	NNS	_	14	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HLA-DRA	hla-dra	NN	NN	_	9	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	replaced	replace	VBN	VBN	_	5	advcl	_	_
21	with	with	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	analogous	analogous	JJ	JJ	_	24	amod	_	_
24	regions	region	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	HLA-DQB	hla-dqb	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	DQB	dqb	NN	NN	_	3	compound	_	_
3	X2-box	x2-box	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	restore	restore	VB	VB	_	5	xcomp	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	to	to	TO	TO	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	silent	silent	JJ	JJ	_	14	amod	_	_
12	DRA	dra	NN	NN	_	14	compound	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	construct	construct	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	replacement	replacement	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DQB	dqb	NN	NN	_	7	compound	_	_
7	X2-box	x2-box	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DRA	dra	NN	NN	_	11	compound	_	_
11	X2-box	x2-box	NN	NN	_	3	nmod	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	diminished	diminish	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	DQB	dqb	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	mutant	mutant	JJ	JJ	_	23	amod	_	_
23	cell	cell	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	None	none	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	hybrid	hybrid	NN	NN	_	6	compound	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	1	nmod	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	defective	defective	JJ	JJ	_	0	root	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	transfected	transfect	VBN	VBN	_	8	advcl	_	_
11	into	into	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	wild-type	wild-type	JJ	JJ	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	HLA-DR/-DQ	hla-dr/-dq	NN	NN	_	19	compound	_	_
16	positive	positive	JJ	JJ	_	19	amod	_	_
17	parental	parental	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	13	appos	_	_
20	,	,	,	,	_	13	punct	_	_
21	Jijoye	jijoye	NN	NN	_	13	appos	_	_
22	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	divergent	divergent	JJ	JJ	_	7	amod	_	_
7	X2-box	x2-box	NN	NN	_	16	nsubj	_	_
8	of	of	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	class	class	NN	NN	_	15	compound	_	_
11	II	ii	CD	CD	_	15	nummod	_	_
12	major	major	JJ	JJ	_	15	amod	_	_
13	histocompatibility	histocompatibility	NN	NN	_	15	compound	_	_
14	complex	complex	NN	NN	_	15	compound	_	_
15	promoters	promoter	NNS	NNS	_	7	nmod	_	_
16	plays	play	VBZ	VBZ	_	3	ccomp	_	_
17	an	a	DT	DT	_	19	det	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	influencing	influence	VBG	VBG	_	16	advcl	_	_
22	differential	differential	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	class	class	NN	NN	_	29	compound	_	_
28	II	ii	CD	CD	_	29	nummod	_	_
29	isotypes	isotype	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	transcription	transcription	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	interleukin-2	interleukin-2	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	B-lymphocytes	b-lymphocyte	NNS	NNS	_	4	nmod	_	_
11	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	Since	since	IN	IN	_	12	mark	_	_
2	most	most	JJS	JJS	_	5	amod	_	_
3	B	b	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	12	nsubjpass	_	_
6	immortalized	immortalize	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	9	case	_	_
8	EBV	ebv	NN	NN	_	9	compound	_	_
9	virus	virus	NN	NN	_	6	nmod	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	24	advcl	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	produce	produce	VB	VB	_	12	xcomp	_	_
15	interleukin-2	interleukin-2	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	21	det	_	_
18	typical	typical	JJ	JJ	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	cytokine	cytokine	NN	NN	_	15	appos	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	studied	study	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	role	role	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	different	different	JJ	JJ	_	29	amod	_	_
29	elements	element	NNS	NNS	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	IL-2	il-2	NN	NN	_	33	compound	_	_
33	promoter	promoter	NN	NN	_	29	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	such	such	JJ	JJ	_	36	amod	_	_
36	clones	clone	NNS	NNS	_	29	nmod	_	_
37	by	by	IN	IN	_	38	case	_	_
38	transfection	transfection	NN	NN	_	24	nmod	_	_
39	.	.	.	.	_	24	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	6	case	_	_
6	particular	particular	JJ	JJ	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	that	that	IN	IN	_	22	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	element	element	NN	NN	_	22	nsubj	_	_
11	TCEd	tced	NN	NN	_	10	dep	_	_
12	,	,	,	,	_	10	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	10	acl:relcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	14	dobj	_	_
18	NF-kB	nf-kb	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	10	punct	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	very	very	RB	RB	_	22	advmod	_	_
22	active	active	JJ	JJ	_	3	ccomp	_	_
23	in	in	IN	IN	_	27	case	_	_
24	all	all	DT	DT	_	27	det	_	_
25	three	three	CD	CD	_	27	nummod	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	clones	clone	NNS	NNS	_	22	nmod	_	_
28	tested	test	VBN	VBN	_	27	acl	_	_
29	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	no	no	DT	DT	_	5	neg	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Jurkat	jurkat	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NFATd	nfatd	NN	NN	_	3	compound	_	_
3	element	element	NN	NN	_	22	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	6	dobj	_	_
10	NFAT-1	nfat-1	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	very	very	RB	RB	_	14	advmod	_	_
14	active	active	JJ	JJ	_	6	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	is	be	VBZ	VBZ	_	22	cop	_	_
20	only	only	RB	RB	_	22	advmod	_	_
21	weakly	weakly	RB	RB	_	22	advmod	_	_
22	active	active	JJ	JJ	_	0	root	_	_
23	in	in	IN	IN	_	26	case	_	_
24	one	one	CD	CD	_	26	nummod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	clone	clone	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	not	not	RB	RB	_	30	neg	_	_
29	at	at	IN	IN	_	30	case	_	_
30	all	all	DT	DT	_	26	conj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	another	another	DT	DT	_	26	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	elements	element	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	contribute	contribute	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Changes	change	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	10	case	_	_
3	triiodothyronine	triiodothyronine	NN	NN	_	10	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	T3	t3	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
8	leukocyte	leukocyte	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	kinetics	kinetics	NNS	NNS	_	1	nmod	_	_
11	after	after	IN	IN	_	13	case	_	_
12	T3	t3	NN	NN	_	13	compound	_	_
13	administration	administration	NN	NN	_	1	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	multiple	multiple	JJ	JJ	_	17	amod	_	_
16	cold-air	cold-air	JJ	JJ	_	17	amod	_	_
17	exposures	exposure	NNS	NNS	_	13	conj	_	_
18	.	.	.	.	_	1	punct	_	_

1	Repeated	repeat	VBN	VBN	_	3	amod	_	_
2	cold-air	cold-air	JJ	JJ	_	3	amod	_	_
3	exposures	exposure	NNS	NNS	_	4	nsubj	_	_
4	increase	increase	VBP	VBP	_	0	root	_	_
5	human	human	JJ	JJ	_	12	amod	_	_
6	triiodothyronine	triiodothyronine	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	T3	t3	CD	CD	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	plasma	plasma	NN	NN	_	12	compound	_	_
11	clearance	clearance	NN	NN	_	12	compound	_	_
12	rates	rate	NNS	NNS	_	4	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	20	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	response	response	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	T3	t3	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NT3R	nt3r	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	condition	condition	NN	NN	_	4	nmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	characteristics	characteristic	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	analyzed	analyze	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	mononuclear	mononuclear	JJ	JJ	_	24	amod	_	_
24	leukocytes	leukocyte	NNS	NNS	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MNL	mnl	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	supplemented	supplement	VBD	VBD	_	0	root	_	_
6	one	one	CD	CD	_	7	nummod	_	_
7	group	group	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	individuals	individual	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	daily	daily	RB	RB	_	15	advmod	_	_
13	oral	oral	JJ	JJ	_	15	amod	_	_
14	replacement	replacement	NN	NN	_	15	compound	_	_
15	dose	dose	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	T3	t3	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	isolate	isolate	VB	VB	_	5	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	influence	influence	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	33	case	_	_
23	serum	serum	NN	NN	_	24	compound	_	_
24	thyroxine	thyroxine	NN	NN	_	33	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	T4	t4	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	thyrotropin	thyrotropin	NN	NN	_	24	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	TSH	tsh	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	levels	level	NNS	NNS	_	21	nmod	_	_
34	on	on	IN	IN	_	36	case	_	_
35	receptor	receptor	NN	NN	_	36	compound	_	_
36	kinetics	kinetics	NNS	NNS	_	21	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	subjects	subject	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	exposed	expose	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	cold	cold	JJ	JJ	_	7	amod	_	_
7	air	air	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	4	4	CD	CD	_	11	nummod	_	_
10	degrees	degree	NNS	NNS	_	11	compound	_	_
11	C	c	NN	NN	_	7	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	twice/d	twice/d	RB	RB	_	4	advmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	30	30	CD	CD	_	16	nummod	_	_
16	min/exposure	min/exposure	NN	NN	_	4	dobj	_	_
17	,	,	,	,	_	4	punct	_	_
18	for	for	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	total	total	NN	NN	_	4	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	80	80	CD	CD	_	23	nummod	_	_
23	exposures	exposure	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	T3-	t3-	JJ	JJ	_	3	amod	_	_
3	subjects	subject	NNS	NNS	_	4	nsubj	_	_
4	received	receive	VBD	VBD	_	0	root	_	_
5	placebo	placebo	NN	NN	_	4	dobj	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	8	punct	_	_
7	n	n	NN	NN	_	8	nsubj	_	_
8	=	=	JJ	JJ	_	5	dep	_	_
9	8	8	CD	CD	_	8	dobj	_	_
10	-RSB-	-rsb-	-RRB-	-RRB-	_	8	punct	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	T3+	t3+	JJ	JJ	_	14	amod	_	_
14	subjects	subject	NNS	NNS	_	15	nsubj	_	_
15	received	receive	VBD	VBD	_	4	conj	_	_
16	T3	t3	CD	CD	_	15	dobj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	30	30	CD	CD	_	19	nummod	_	_
19	micrograms/d	micrograms/d	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
22	n	n	NN	NN	_	23	nsubj	_	_
23	=	=	JJ	JJ	_	16	dep	_	_
24	8	8	CD	CD	_	23	dobj	_	_
25	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_
26	in	in	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	double-blind	double-blind	JJ	JJ	_	29	amod	_	_
29	fashion	fashion	NN	NN	_	4	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	leukocytes	leukocyte	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	isolated	isolate	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
7	blood	blood	NN	NN	_	4	nmod	_	_
8	before	before	IN	IN	_	15	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cold	cold	JJ	JJ	_	11	amod	_	_
11	exposure	exposure	NN	NN	_	15	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	drug	drug	NN	NN	_	14	compound	_	_
14	regimen	regimen	NNS	NNS	_	11	conj	_	_
15	began	begin	VBD	VBD	_	4	advcl	_	_
16	,	,	,	,	_	4	punct	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	then	then	RB	RB	_	4	conj	_	_
19	after	after	IN	IN	_	22	case	_	_
20	every	every	DT	DT	_	21	advmod	_	_
21	20	20	CD	CD	_	22	nummod	_	_
22	exposures	exposure	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dissociation	dissociation	NN	NN	_	3	compound	_	_
3	constant	constant	NN	NN	_	20	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	Kd	kd	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	maximum	maximum	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	capacity	capacity	NN	NN	_	3	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MBC	mbc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	NT3R	nt3r	NN	NN	_	17	compound	_	_
17	values	value	NNS	NNS	_	3	nmod	_	_
18	were	be	VBD	VBD	_	20	auxpass	_	_
19	log	log	NN	NN	_	20	dep	_	_
20	transformed	transform	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	minimize	minimize	VB	VB	_	20	xcomp	_	_
23	between-subject	between-subject	JJ	JJ	_	24	amod	_	_
24	variability	variability	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	T3+	t3+	JJ	JJ	_	4	amod	_	_
4	group	group	NN	NN	_	25	nmod	_	_
5	,	,	,	,	_	25	punct	_	_
6	serum	serum	NN	NN	_	8	compound	_	_
7	total	total	VBP	VBP	_	8	dep	_	_
8	thyroxine	thyroxine	NN	NN	_	25	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	TT4	tt4	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	free	free	JJ	JJ	_	14	amod	_	_
14	T4	t4	NN	NN	_	8	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	FT4	ft4	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	8	punct	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	TSH	tsh	NN	NN	_	8	conj	_	_
21	were	be	VBD	VBD	_	25	cop	_	_
22	approx	approx	RB	RB	_	23	advmod	_	_
23	50	50	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	25	nmod:npmod	_	_
25	lower	lower	JJR	JJR	_	0	root	_	_
26	than	than	IN	IN	_	28	case	_	_
27	both	both	CC	CC	_	28	cc:preconj	_	_
28	basal	basal	JJ	JJ	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	T3-values	t3-value	NNS	NNS	_	28	conj	_	_
31	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	log10Kd	log10kd	NN	NN	_	3	nsubj	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	0.304	0.304	CD	CD	_	3	dobj	_	_
5	+/-	+/-	CC	CC	_	4	cc	_	_
6	0.139	0.139	CD	CD	_	4	conj	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	p	p	NN	NN	_	10	dep	_	_
9	&lt;	&lt;	JJR	JJR	_	10	advmod	_	_
10	0.04	0.04	CD	CD	_	3	parataxis	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	log10MBC	log10mbc	NN	NN	_	15	nsubj	_	_
15	increased	increase	VBD	VBD	_	3	conj	_	_
16	0.49	0.49	CD	CD	_	15	dobj	_	_
17	+/-	+/-	CC	CC	_	16	cc	_	_
18	0.10	0.10	CD	CD	_	16	conj	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	p	p	NN	NN	_	22	dep	_	_
21	&lt;	&lt;	JJR	JJR	_	22	advmod	_	_
22	0.001	0.001	CD	CD	_	15	parataxis	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	T3+	t3+	JJ	JJ	_	27	amod	_	_
27	subjects	subject	NNS	NNS	_	3	nmod	_	_
28	compared	compare	VBN	VBN	_	30	case	_	_
29	to	to	TO	TO	_	30	case	_	_
30	baseline	baseline	NN	NN	_	3	advcl	_	_
31	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	change	change	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	MBC	mbc	NN	NN	_	2	nmod	_	_
5	represents	represent	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	311	311	CD	CD	_	9	nummod	_	_
8	%	%	NN	NN	_	9	compound	_	_
9	increase	increase	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	MBC	mbc	NN	NN	_	9	nmod	_	_
13	over	over	IN	IN	_	14	case	_	_
14	baseline	baseline	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	fivefold	fivefold	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	9	conj	_	_
19	over	over	IN	IN	_	21	case	_	_
20	placebo-treated	placebo-treated	JJ	JJ	_	21	amod	_	_
21	subjects	subject	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	T3-	t3-	JJ	JJ	_	3	amod	_	_
3	group	group	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	change	change	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	MBC	mbc	NN	NN	_	6	nmod	_	_
9	over	over	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	study	study	NN	NN	_	4	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	time	time	NN	NN	_	3	nmod	_	_
8	the	the	DT	DT	_	10	det	_	_
9	rapid	rapid	JJ	JJ	_	10	amod	_	_
10	modulation	modulation	NN	NN	_	3	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	NT3R	nt3r	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	response	response	NN	NN	_	19	dep	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	combined	combined	JJ	JJ	_	19	amod	_	_
19	influence	influence	NN	NN	_	10	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cold	cold	JJ	JJ	_	22	amod	_	_
22	exposure	exposure	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	reduced	reduce	VBN	VBN	_	26	amod	_	_
25	circulating	circulate	VBG	VBG	_	26	amod	_	_
26	T4	t4	NN	NN	_	22	conj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	TSH	tsh	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Nitric	nitric	JJ	JJ	_	2	amod	_	_
2	oxide-stimulated	oxide-stimulated	JJ	JJ	_	5	amod	_	_
3	guanine	guanine	NN	NN	_	5	compound	_	_
4	nucleotide	nucleotide	NN	NN	_	5	compound	_	_
5	exchange	exchange	NN	NN	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	p21ras	p21ras	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protooncogene	protooncogene	NN	NN	_	3	compound	_	_
3	p21ras	p21ras	NN	NN	_	12	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	10	det	_	_
6	monomeric	monomeric	JJ	JJ	_	10	amod	_	_
7	G	g	NN	NN	_	10	compound	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	member	member	NN	NN	_	3	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	plays	play	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	critical	critical	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	converting	convert	VBG	VBG	_	12	advcl	_	_
18	extracellular	extracellular	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	17	dobj	_	_
20	into	into	IN	IN	_	23	case	_	_
21	intracellular	intracellular	JJ	JJ	_	23	amod	_	_
22	biochemical	biochemical	JJ	JJ	_	23	amod	_	_
23	events	event	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	nitric	nitric	JJ	JJ	_	7	amod	_	_
7	oxide	oxide	NN	NN	_	11	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NO	no	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	activates	activate	VBZ	VBZ	_	4	ccomp	_	_
12	p21ras	p21ras	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	evidenced	evidence	VBN	VBN	_	11	advcl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	GTP-bound	gtp-bound	JJ	JJ	_	24	amod	_	_
24	p21ras	p21ras	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	8	nsubj	_	_
4	using	use	VBG	VBG	_	3	acl	_	_
5	pure	pure	JJ	JJ	_	7	amod	_	_
6	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
7	p21ras	p21ras	NN	NN	_	4	dobj	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	direct	direct	JJ	JJ	_	8	ccomp	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	reversible	reversible	JJ	JJ	_	13	conj	_	_
16	.	.	.	.	_	8	punct	_	_

1	Circular	circular	JJ	JJ	_	3	amod	_	_
2	dichroism	dichroism	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	reveals	reveal	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	NO	no	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	profound	profound	JJ	JJ	_	11	amod	_	_
10	conformational	conformational	JJ	JJ	_	11	amod	_	_
11	change	change	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	p21ras	p21ras	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	association	association	NN	NN	_	7	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	GDP/GTP	gdp/gtp	NN	NN	_	18	compound	_	_
18	exchange	exchange	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	due	due	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	S-nitrosylation	s-nitrosylation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	critical	critical	JJ	JJ	_	13	amod	_	_
12	cysteine	cysteine	NN	NN	_	13	compound	_	_
13	residue	residue	NN	NN	_	8	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	stimulates	stimulate	VBZ	VBZ	_	8	acl:relcl	_	_
16	guanine	guanine	NN	NN	_	18	compound	_	_
17	nucleotide	nucleotide	NN	NN	_	18	compound	_	_
18	exchange	exchange	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	p21ras	p21ras	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	essential	essential	JJ	JJ	_	4	ccomp	_	_
9	for	for	IN	IN	_	12	case	_	_
10	NO-induced	no-induced	JJ	JJ	_	12	amod	_	_
11	downstream	downstream	JJ	JJ	_	12	amod	_	_
12	signaling	signaling	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	such	such	JJ	JJ	_	18	case	_	_
15	as	as	IN	IN	_	14	mwe	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	endogenous	endogenous	JJ	JJ	_	23	amod	_	_
23	NO	no	NN	NN	_	25	nsubj	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	activate	activate	VB	VB	_	8	conj	_	_
26	p21ras	p21ras	NN	NN	_	25	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	same	same	JJ	JJ	_	30	amod	_	_
30	cell	cell	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	p21ras	p21ras	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	target	target	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	same	same	JJ	JJ	_	11	amod	_	_
11	cell	cell	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	p21ras	p21ras	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	target	target	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NO	no	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	suggest	suggest	VBP	VBP	_	3	conj	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	NO	no	NN	NN	_	17	nsubj	_	_
17	activates	activate	VBZ	VBZ	_	14	ccomp	_	_
18	p21ras	p21ras	NN	NN	_	17	dobj	_	_
19	by	by	IN	IN	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	action	action	NN	NN	_	17	nmod	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	mimics	mimic	VBZ	VBZ	_	21	acl:relcl	_	_
24	that	that	DT	DT	_	23	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	guanine	guanine	NN	NN	_	29	compound	_	_
27	nucleotide	nucleotide	NN	NN	_	29	compound	_	_
28	exchange	exchange	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	vacuolar	vacuolar	JJ	JJ	_	9	amod	_	_
6	H(+)-ATPase	h(+)-atpase	NN	NN	_	9	compound	_	_
7	B2	b2	NN	NN	_	9	compound	_	_
8	subunit	subunit	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	differentiating	differentiate	VBG	VBG	_	13	amod	_	_
12	THP-1	thp-1	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	model	model	NN	NN	_	8	compound	_	_
8	system	system	NN	NN	_	4	nmod	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	studying	study	VBG	VBG	_	8	acl	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	regulation	regulation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	vacuolar	vacuolar	NN	NN	_	17	compound	_	_
17	H(+)-ATPase	h(+)-atpase	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	V-ATPase	v-atpase	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	various	various	JJ	JJ	_	8	amod	_	_
7	V-ATPase	v-atpase	NN	NN	_	8	compound	_	_
8	subunits	subunit	NNS	NNS	_	4	nmod	_	_
9	during	during	IN	IN	_	10	case	_	_
10	differentiation	differentiation	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	native	native	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	14	conj	_	_
19	THP-1	thp-1	NN	NN	_	18	dep	_	_
20	,	,	,	,	_	2	punct	_	_
21	and	and	CC	CC	_	2	cc	_	_
22	found	find	VBD	VBD	_	2	conj	_	_
23	that	that	IN	IN	_	29	mark	_	_
24	transcriptional	transcriptional	JJ	JJ	_	29	nsubj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	post-transcriptional	post-transcriptional	JJ	JJ	_	24	conj	_	_
27	mechanisms	mechanism	NNS	NNS	_	24	dep	_	_
28	could	could	MD	MD	_	29	aux	_	_
29	account	account	VB	VB	_	22	ccomp	_	_
30	for	for	IN	IN	_	31	case	_	_
31	increases	increase	NNS	NNS	_	29	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	V-ATPase	v-atpase	NN	NN	_	35	compound	_	_
35	content	content	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	From	from	IN	IN	_	4	case	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	runoff	runoff	JJ	JJ	_	4	amod	_	_
4	experiments	experiment	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	found	find	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	24	mark	_	_
9	one	one	CD	CD	_	10	nummod	_	_
10	subunit	subunit	NN	NN	_	24	nsubjpass	_	_
11	in	in	IN	IN	_	12	case	_	_
12	particular	particular	JJ	JJ	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	B2	b2	NN	NN	_	16	compound	_	_
16	isoform	isoform	NN	NN	_	10	appos	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Mr	mr	NN	NN	_	16	dep	_	_
19	=	=	JJ	JJ	_	18	amod	_	_
20	56,000	56,000	CD	CD	_	19	dep	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	,	,	,	,	_	10	punct	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	amplified	amplify	VBN	VBN	_	7	ccomp	_	_
25	primarily	primarily	RB	RB	_	24	advmod	_	_
26	by	by	IN	IN	_	28	case	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	means	means	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	begun	begin	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	examine	examine	VB	VB	_	3	xcomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	structure	structure	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	B2	b2	NN	NN	_	13	compound	_	_
11	subunit	subunit	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Isolation	isolation	NN	NN	_	14	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	sequencing	sequencing	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	exon	exon	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	5'-flanking	5'-flanking	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	7	nmod	_	_
14	reveal	reveal	VBP	VBP	_	0	root	_	_
15	a	a	DT	DT	_	17	det	_	_
16	TATA-less	tata-less	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	14	dobj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	high	high	JJ	JJ	_	21	amod	_	_
21	G	g	NN	NN	_	17	nmod	_	_
22	+	+	CC	CC	_	21	cc	_	_
23	C	c	NN	NN	_	24	compound	_	_
24	content	content	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	14	punct	_	_

1	Primer	primer	NN	NN	_	2	compound	_	_
2	extension	extension	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	ribonuclease	ribonuclease	NN	NN	_	5	compound	_	_
5	protection	protection	NN	NN	_	2	conj	_	_
6	analyses	analysis	NNS	NNS	_	2	dep	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	13	det	_	_
9	single	single	JJ	JJ	_	13	amod	_	_
10	major	major	JJ	JJ	_	13	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
12	start	start	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	7	dobj	_	_
14	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	transfected	transfect	VBD	VBD	_	0	root	_	_
3	promoter-luciferase	promoter-luciferase	NN	NN	_	5	compound	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	plasmids	plasmid	NNS	NNS	_	2	dobj	_	_
6	into	into	IN	IN	_	8	case	_	_
7	THP-1	thp-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	define	define	VB	VB	_	2	advcl	_	_
11	sequences	sequence	NNS	NNS	_	10	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	mediate	mediate	VBP	VBP	_	11	acl:relcl	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	control	control	NN	NN	_	13	dobj	_	_
16	during	during	IN	IN	_	18	case	_	_
17	monocyte	monocyte	NN	NN	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	sequences	sequence	NNS	NNS	_	12	nsubj	_	_
5	downstream	downstream	RB	RB	_	4	advmod	_	_
6	from	from	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	start	start	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	sufficient	sufficient	JJ	JJ	_	2	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	confer	confer	VB	VB	_	12	xcomp	_	_
15	increased	increase	VBN	VBN	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	during	during	IN	IN	_	19	case	_	_
18	THP-1	thp-1	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	DNase	dnase	NN	NN	_	7	nsubj	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	footprinting	footprinting	NN	NN	_	1	dep	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	sequence	sequence	NN	NN	_	1	conj	_	_
6	analysis	analysis	NN	NN	_	1	dep	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	existence	existence	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	multiple	multiple	JJ	JJ	_	12	amod	_	_
12	AP2	ap2	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Sp1	sp1	NN	NN	_	12	conj	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	12	dep	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	5'-untranslated	5'-untranslated	JJ	JJ	_	9	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	proximal	proximal	JJ	JJ	_	22	dep	_	_
22	coding	code	VBG	VBG	_	19	conj	_	_
23	regions	region	NNS	NNS	_	19	dep	_	_
24	.	.	.	.	_	7	punct	_	_

1	cDNA	cdna	NN	NN	_	2	compound	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	NGFI-B/nur77-related	ngfi-b/nur77-related	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	from	from	IN	IN	_	14	case	_	_
9	an	a	DT	DT	_	14	det	_	_
10	apoptotic	apoptotic	JJ	JJ	_	14	amod	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	2	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	T	t	NN	NN	_	6	compound	_	_
4	lymphoid	lymphoid	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	10	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	PEER	peer	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	dies	die	VBZ	VBZ	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	apoptosis	apoptosis	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	PMA	pma	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	ionophore	ionophore	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	gene	gene	NN	NN	_	8	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	TINUR	tinur	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	cloned	clone	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	12	case	_	_
10	apoptotic	apoptotic	JJ	JJ	_	12	amod	_	_
11	PEER	peer	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TINUR	tinur	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	within	within	IN	IN	_	11	case	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	8	nmod	_	_
12	after	after	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cross-linking	cross-linking	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	T	t	NN	NN	_	21	compound	_	_
18	cell	cell	NN	NN	_	21	compound	_	_
19	Ag	ag	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	complex	complex	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	TINUR	tinur	NN	NN	_	2	nsubj	_	_
2	belongs	belong	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	steroid	steroid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	superfamily	superfamily	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	an	a	DT	DT	_	16	det	_	_
15	orphan	orphan	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	2	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	TINUR	tinur	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	same	same	JJ	JJ	_	7	amod	_	_
6	DNA	dna	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	2	nmod	_	_
8	as	as	IN	IN	_	9	case	_	_
9	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	propose	propose	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	10	nsubjpass	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	classified	classify	VBN	VBN	_	3	ccomp	_	_
11	into	into	IN	IN	_	13	case	_	_
12	two	two	CD	CD	_	13	nummod	_	_
13	subtypes	subtype	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	intranasal	intranasal	JJ	JJ	_	4	amod	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	endogenous	endogenous	JJ	JJ	_	7	amod	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	1	nmod	_	_
8	peripheral	peripheral	JJ	JJ	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	central	central	JJ	JJ	_	7	conj	_	_
11	function	function	NN	NN	_	7	dep	_	_
12	.	.	.	.	_	1	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	8	nsubj	_	_
2	are	be	VBP	VBP	_	8	cop	_	_
3	among	among	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	most	most	RBS	RBS	_	7	advmod	_	_
6	potent	potent	JJ	JJ	_	7	amod	_	_
7	antiinflammatory	antiinflammatory	JJ	JJ	_	8	amod	_	_
8	agents	agent	NNS	NNS	_	0	root	_	_
9	that	that	WDT	WDT	_	12	nsubjpass	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	8	acl:relcl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	rhinitis	rhinitis	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Their	they	PRP$	PRP$	_	2	nmod:poss	_	_
2	mechanisms	mechanism	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	action	action	NN	NN	_	2	nmod	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	multiple	multiple	JJ	JJ	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	complex	complex	JJ	JJ	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	a	a	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	14	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	reports	report	NNS	NNS	_	11	nmod	_	_
14	describe	describe	VBP	VBP	_	6	conj	_	_
15	significant	significant	JJ	JJ	_	17	amod	_	_
16	systemic	systemic	JJ	JJ	_	15	dep	_	_
17	effects	effect	NNS	NNS	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	locally	locally	RB	RB	_	20	advmod	_	_
20	administered	administer	VBN	VBN	_	21	amod	_	_
21	glucocorticoids	glucocorticoid	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	evaluate	evaluate	VB	VB	_	19	advcl	_	_
5	the	the	DT	DT	_	8	det	_	_
6	short-term	short-term	JJ	JJ	_	7	amod	_	_
7	systemic	systemic	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	intranasally	intranasally	RB	RB	_	11	advmod	_	_
11	administered	administer	VBN	VBN	_	12	amod	_	_
12	glucocorticoids	glucocorticoid	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	19	punct	_	_
14	14	14	CD	CD	_	17	nummod	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	healthy	healthy	JJ	JJ	_	15	dep	_	_
17	subjects	subject	NNS	NNS	_	19	nsubjpass	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	treated	treat	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	22	case	_	_
21	two	two	CD	CD	_	22	nummod	_	_
22	doses	dose	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	either	either	CC	CC	_	25	cc:preconj	_	_
25	budesonide	budesonide	NN	NN	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	BUD	bud	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	or	or	CC	CC	_	25	cc	_	_
30	fluticasone	fluticasone	NN	NN	_	31	compound	_	_
31	propionate	propionate	NN	NN	_	25	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	FP	fp	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	for	for	IN	IN	_	37	case	_	_
36	2	2	CD	CD	_	37	nummod	_	_
37	weeks	week	NNS	NNS	_	19	nmod	_	_
38	.	.	.	.	_	19	punct	_	_

1	Before	before	IN	IN	_	2	case	_	_
2	treatment	treatment	NN	NN	_	39	dep	_	_
3	,	,	,	,	_	2	punct	_	_
4	at	at	IN	IN	_	6	case	_	_
5	regular	regular	JJ	JJ	_	6	amod	_	_
6	intervals	interval	NNS	NNS	_	2	dep	_	_
7	during	during	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	treatment	treatment	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	1	1	CD	CD	_	12	nummod	_	_
12	week	week	NN	NN	_	2	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	finally	finally	RB	RB	_	16	advmod	_	_
15	6	6	CD	CD	_	16	nummod	_	_
16	weeks	week	NNS	NNS	_	12	conj	_	_
17	after	after	IN	IN	_	18	case	_	_
18	termination	termination	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	treatment	treatment	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	39	punct	_	_
22	the	the	DT	DT	_	23	det	_	_
23	effects	effect	NNS	NNS	_	39	nsubjpass	_	_
24	on	on	IN	IN	_	26	case	_	_
25	glucocorticoid	glucocorticoid	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	23	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	GR	gr	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	methallothionein	methallothionein	NN	NN	_	36	compound	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	MTIIa	mtiia	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	mRNA	mrna	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	26	conj	_	_
37	levels	level	NNS	NNS	_	26	dep	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	examined	examine	VBN	VBN	_	0	root	_	_
40	in	in	IN	IN	_	42	case	_	_
41	peripheral	peripheral	JJ	JJ	_	42	amod	_	_
42	lymphocytes	lymphocyte	NNS	NNS	_	39	nmod	_	_
43	using	use	VBG	VBG	_	39	xcomp	_	_
44	a	a	DT	DT	_	47	det	_	_
45	solution	solution	NN	NN	_	47	compound	_	_
46	hybridization	hybridization	NN	NN	_	47	compound	_	_
47	assay	assay	NN	NN	_	43	dobj	_	_
48	.	.	.	.	_	39	punct	_	_

1	Serum	serum	NN	NN	_	2	compound	_	_
2	cortisol	cortisol	NN	NN	_	11	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	osteocalcin	osteocalcin	NN	NN	_	2	conj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	urinary	urinary	JJ	JJ	_	7	amod	_	_
7	cortisol	cortisol	NN	NN	_	2	conj	_	_
8	levels	level	NNS	NNS	_	2	dep	_	_
9	were	be	VBD	VBD	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	determined	determine	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	insulin	insulin	NN	NN	_	4	compound	_	_
3	tolerance	tolerance	NN	NN	_	4	compound	_	_
4	test	test	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	ITT	itt	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	performed	perform	VBN	VBN	_	0	root	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	end	end	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	second	second	JJ	JJ	_	16	amod	_	_
16	week	week	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	treatment	treatment	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	at	at	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	end	end	NN	NN	_	12	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	6-week	6-week	JJ	JJ	_	27	amod	_	_
26	washout	washout	NN	NN	_	27	compound	_	_
27	period	period	NN	NN	_	22	nmod	_	_
28	with	with	IN	IN	_	32	case	_	_
29	no	no	DT	DT	_	32	neg	_	_
30	statistically	statistically	RB	RB	_	31	advmod	_	_
31	significant	significant	JJ	JJ	_	32	amod	_	_
32	change	change	NN	NN	_	9	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	cortisol	cortisol	NN	NN	_	35	compound	_	_
35	response	response	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	peripheral	peripheral	JJ	JJ	_	3	amod	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	GR	gr	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	10	nsubjpass	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	MTIIa	mtiia	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	4	nsubj	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	significantly	significantly	RB	RB	_	4	advmod	_	_
6	.	.	.	.	_	4	punct	_	_

1	Serum	serum	NN	NN	_	3	nsubj	_	_
2	osteocalcin	osteocalcin	NN	NN	_	1	dep	_	_
3	decreased	decrease	VBD	VBD	_	0	root	_	_
4	significantly	significantly	RB	RB	_	3	advmod	_	_
5	during	during	IN	IN	_	6	case	_	_
6	treatment	treatment	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	BUD	bud	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	FP	fp	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	Serum	serum	NN	NN	_	2	compound	_	_
2	cortisol	cortisol	NN	NN	_	3	nsubj	_	_
3	decreased	decrease	VBD	VBD	_	0	root	_	_
4	after	after	IN	IN	_	6	case	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	week	week	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	treatment	treatment	NN	NN	_	6	nmod	_	_
9	whereas	whereas	IN	IN	_	14	mark	_	_
10	urinary	urinary	JJ	JJ	_	11	amod	_	_
11	cortisol	cortisol	NN	NN	_	14	nsubjpass	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	affected	affect	VBN	VBN	_	3	advcl	_	_
15	until	until	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	second	second	JJ	JJ	_	18	amod	_	_
18	week	week	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	treatment	treatment	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	intranasal	intranasal	JJ	JJ	_	5	amod	_	_
5	glucocorticoids	glucocorticoid	NNS	NNS	_	10	nsubj	_	_
6	at	at	IN	IN	_	8	case	_	_
7	clinically	clinically	RB	RB	_	8	advmod	_	_
8	recommended	recommend	VBN	VBN	_	5	acl	_	_
9	doses	dose	NNS	NNS	_	8	dep	_	_
10	have	have	VBP	VBP	_	0	root	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	only	only	RB	RB	_	10	dep	_	_
13	significant	significant	JJ	JJ	_	14	amod	_	_
14	systemic	systemic	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	10	conj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	adrenal	adrenal	JJ	JJ	_	18	amod	_	_
18	function	function	NN	NN	_	10	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	but	but	CC	CC	_	10	cc	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	have	have	VBP	VBP	_	10	conj	_	_
23	an	a	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	22	dobj	_	_
25	on	on	IN	IN	_	28	case	_	_
26	specific	specific	JJ	JJ	_	28	amod	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	22	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	peripheral	peripheral	JJ	JJ	_	31	amod	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	receptor-dependent	receptor-dependent	JJ	JJ	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	reversible	reversible	JJ	JJ	_	4	dep	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	according	accord	VBG	VBG	_	11	case	_	_
10	to	to	TO	TO	_	9	mwe	_	_
11	serum	serum	NN	NN	_	4	conj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	urinary	urinary	JJ	JJ	_	14	amod	_	_
14	cortisol	cortisol	NN	NN	_	11	conj	_	_
15	levels	level	NNS	NNS	_	11	dep	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	ITT	itt	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	4	punct	_	_
19	leave	leave	VBP	VBP	_	4	conj	_	_
20	the	the	DT	DT	_	22	det	_	_
21	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	22	amod	_	_
22	function	function	NN	NN	_	23	nsubj	_	_
23	intact	intact	JJ	JJ	_	19	xcomp	_	_
24	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	these	these	DT	DT	_	6	det	_	_
4	short-term	short-term	JJ	JJ	_	5	amod	_	_
5	systemic	systemic	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	any	any	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	noticeable	noticeable	JJ	JJ	_	15	amod	_	_
15	side-effects	side-effect	NNS	NNS	_	11	nmod	_	_
16	usually	usually	RB	RB	_	17	advmod	_	_
17	observed	observe	VBN	VBN	_	15	acl	_	_
18	during	during	IN	IN	_	20	case	_	_
19	long-term	long-term	JJ	JJ	_	20	amod	_	_
20	treatment	treatment	NN	NN	_	17	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	glucocorticoids	glucocorticoid	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	12	case	_	_
4	core	core	NN	NN	_	12	compound	_	_
5	binding	binding	NN	NN	_	12	compound	_	_
6	factor-alpha	factor-alpha	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	AML1	aml1	NN	NN	_	12	compound	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	12	cc	_	_
11	beta	beta	NN	NN	_	12	compound	_	_
12	subunits	subunit	NNS	NNS	_	2	nmod	_	_
13	on	on	IN	IN	_	18	case	_	_
14	murine	murine	JJ	JJ	_	18	amod	_	_
15	leukemia	leukemia	NN	NN	_	18	compound	_	_
16	virus	virus	NN	NN	_	18	compound	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	cores	core	NNS	NNS	_	2	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Core	core	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	25	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	CBF	cbf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	known	know	VBN	VBN	_	3	acl	_	_
10	as	as	IN	IN	_	13	case	_	_
11	polyomavirus	polyomavirus	NN	NN	_	13	compound	_	_
12	enhancer-binding	enhancer-binding	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	9	nmod	_	_
14	2	2	CD	CD	_	13	nummod	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	SL3	sl3	NN	NN	_	18	compound	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	13	conj	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	,	,	,	,	_	3	punct	_	_
21	is	be	VBZ	VBZ	_	25	cop	_	_
22	a	a	DT	DT	_	25	det	_	_
23	mammalian	mammalian	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	0	root	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	binds	bind	VBZ	VBZ	_	25	acl:relcl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	an	a	DT	DT	_	30	det	_	_
30	element	element	NN	NN	_	27	nmod	_	_
31	termed	term	VBN	VBN	_	30	acl	_	_
32	the	the	DT	DT	_	33	det	_	_
33	core	core	NN	NN	_	31	xcomp	_	_
34	within	within	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	enhancers	enhancer	NNS	NNS	_	33	nmod	_	_
37	of	of	IN	IN	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	murine	murine	JJ	JJ	_	42	amod	_	_
40	leukemia	leukemia	NN	NN	_	42	compound	_	_
41	virus	virus	NN	NN	_	42	compound	_	_
42	family	family	NN	NN	_	36	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	retroviruses	retrovirus	NNS	NNS	_	42	nmod	_	_
45	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	core	core	NN	NN	_	3	compound	_	_
3	elements	element	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	SL3	sl3	NN	NN	_	7	compound	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	important	important	JJ	JJ	_	11	amod	_	_
10	genetic	genetic	JJ	JJ	_	11	amod	_	_
11	determinants	determinant	NNS	NNS	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	virus	virus	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	induce	induce	VB	VB	_	14	acl	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	lymphomas	lymphoma	NNS	NNS	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	activity	activity	NN	NN	_	21	conj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	viral	viral	JJ	JJ	_	31	amod	_	_
29	long	long	JJ	JJ	_	31	amod	_	_
30	terminal	terminal	JJ	JJ	_	31	amod	_	_
31	repeat	repeat	NN	NN	_	25	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	CBF	cbf	NN	NN	_	2	nsubj	_	_
2	consists	consist	VBZ	VBZ	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	subunits	subunit	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	10	det	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	subunit	subunit	NN	NN	_	5	appos	_	_
11	,	,	,	,	_	10	punct	_	_
12	CBF	cbf	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	10	appos	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	second	second	JJ	JJ	_	18	amod	_	_
18	subunit	subunit	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	CBF	cbf	NN	NN	_	21	compound	_	_
21	beta	beta	NN	NN	_	18	appos	_	_
22	,	,	,	,	_	18	punct	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	stimulates	stimulate	VBZ	VBZ	_	18	acl:relcl	_	_
25	the	the	DT	DT	_	28	det	_	_
26	DNA	dna	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	24	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	CBF	cbf	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	One	one	CD	CD	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	encodes	encode	VBZ	VBZ	_	1	acl:relcl	_	_
7	a	a	DT	DT	_	10	det	_	_
8	CBF	cbf	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	subunit	subunit	NN	NN	_	6	dobj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	AML1	aml1	NN	NN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	called	call	VBN	VBN	_	12	acl	_	_
16	Cbf	cbf	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	15	xcomp	_	_
18	2	2	CD	CD	_	17	nummod	_	_
19	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	locus	locus	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	rearranged	rearrange	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	chromosomal	chromosomal	JJ	JJ	_	7	amod	_	_
7	translocations	translocation	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	myeloproliferative	myeloproliferative	JJ	JJ	_	11	amod	_	_
11	disorders	disorder	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	leukemias	leukemia	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	7	det	_	_
2	exogenously	exogenously	RB	RB	_	3	advmod	_	_
3	expressed	express	VBN	VBN	_	7	amod	_	_
4	Cbf	cbf	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	2-encoded	2-encoded	JJ	JJ	_	7	amod	_	_
7	subunit	subunit	NN	NN	_	13	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	CBF	cbf	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	appos	_	_
11	2-451	2-451	CD	CD	_	10	nummod	_	_
12	)	)	-RRB-	-RRB-	_	10	punct	_	_
13	stimulated	stimulate	VBD	VBD	_	0	root	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	SL3	sl3	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	P19	p19	NN	NN	_	13	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	HeLa	hela	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Activity	activity	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	mediated	mediate	VBN	VBN	_	0	root	_	_
4	through	through	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	core	core	NN	NN	_	7	compound	_	_
7	elements	element	NNS	NNS	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	isoforms	isoform	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	CBF	cbf	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	3	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	tested	test	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	SL3	sl3	NN	NN	_	16	compound	_	_
16	enhancer	enhancer	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	longest	longest	JJS	JJS	_	3	amod	_	_
3	form	form	NN	NN	_	8	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	CBF	cbf	NN	NN	_	6	compound	_	_
6	beta-187	beta-187	NN	NN	_	3	appos	_	_
7	,	,	,	,	_	3	punct	_	_
8	increased	increase	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	stimulation	stimulation	NN	NN	_	8	iobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	CBF	cbf	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	nmod	_	_
15	2-451	2-451	CD	CD	_	14	nummod	_	_
16	twofold	twofold	JJ	JJ	_	8	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	HeLa	hela	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	8	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	although	although	IN	IN	_	23	mark	_	_
22	it	it	PRP	PRP	_	23	nsubj	_	_
23	had	have	VBD	VBD	_	8	advcl	_	_
24	no	no	DT	DT	_	25	neg	_	_
25	effect	effect	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	P19	p19	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	by	by	IN	IN	_	5	case	_	_
4	CBF	cbf	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	2	nmod	_	_
6	required	require	VBD	VBD	_	0	root	_	_
7	binding	binding	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	CBF	cbf	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	subunit	subunit	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	as	as	IN	IN	_	28	mark	_	_
15	a	a	DT	DT	_	16	det	_	_
16	form	form	NN	NN	_	28	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	CBF	cbf	NN	NN	_	19	compound	_	_
19	beta	beta	NN	NN	_	16	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	lacked	lack	VBD	VBD	_	16	acl:relcl	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	ability	ability	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	16	punct	_	_
25	CBF	cbf	NN	NN	_	26	compound	_	_
26	beta-148	beta-148	NN	NN	_	16	appos	_	_
27	,	,	,	,	_	16	punct	_	_
28	failed	fail	VBD	VBD	_	6	advcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	increase	increase	VB	VB	_	28	xcomp	_	_
31	activity	activity	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	at	at	IN	IN	_	10	advmod	_	_
6	least	least	JJS	JJS	_	5	mwe	_	_
7	in	in	IN	IN	_	10	case	_	_
8	certain	certain	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	types	type	NNS	NNS	_	17	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	maximum	maximum	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	17	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CBF	cbf	NN	NN	_	14	nmod	_	_
17	required	require	VBD	VBD	_	3	ccomp	_	_
18	both	both	DT	DT	_	19	det	_	_
19	subunits	subunit	NNS	NNS	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	provided	provide	VBD	VBD	_	0	root	_	_
4	support	support	NN	NN	_	3	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	hypothesis	hypothesis	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	CBF	cbf	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	factor	factor	NN	NN	_	7	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	responsible	responsible	JJ	JJ	_	12	acl:relcl	_	_
19	for	for	IN	IN	_	20	case	_	_
20	recognition	recognition	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	SL3	sl3	NN	NN	_	24	compound	_	_
24	cores	core	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	7	mark	_	_
5	CBF	cbf	NN	NN	_	7	nsubj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	distinguish	distinguish	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	1-bp	1-bp	JJ	JJ	_	10	amod	_	_
10	difference	difference	NN	NN	_	7	dobj	_	_
11	between	between	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	enhancer	enhancer	NN	NN	_	14	compound	_	_
14	core	core	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	SL3	sl3	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	core	core	NN	NN	_	14	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	nonleukemogenic	nonleukemogenic	JJ	JJ	_	23	amod	_	_
23	virus	virus	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	Akv	akv	NN	NN	_	23	appos	_	_
26	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	affects	affect	VBZ	VBZ	_	0	root	_	_
5	transcription	transcription	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	leukemogenicity	leukemogenicity	NN	NN	_	5	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	SL3	sl3	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	combination	combination	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	CBF	cbf	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CBF	cbf	NN	NN	_	10	compound	_	_
10	beta	beta	NN	NN	_	7	conj	_	_
11	subunits	subunit	NNS	NNS	_	7	dep	_	_
12	that	that	WDT	WDT	_	14	dobj	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	tested	test	VBD	VBD	_	4	acl:relcl	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	able	able	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	distinguish	distinguish	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	1-bp	1-bp	JJ	JJ	_	21	amod	_	_
21	difference	difference	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	assays	assay	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	complete	complete	JJ	JJ	_	5	amod	_	_
5	understanding	understanding	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	10	mark	_	_
7	how	how	WRB	WRB	_	10	advmod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	10	nsubj	_	_
10	recognize	recognize	VBP	VBP	_	5	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	SL3	sl3	NN	NN	_	13	compound	_	_
13	core	core	NN	NN	_	10	dobj	_	_
14	remains	remain	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	elucidated	elucidate	VBN	VBN	_	14	xcomp	_	_
18	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	newly	newly	RB	RB	_	3	advmod	_	_
3	established	established	JJ	JJ	_	6	amod	_	_
4	megakaryoblastic/erythroid	megakaryoblastic/erythroid	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	differentiates	differentiate	VBZ	VBZ	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	red	red	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	erythropoietin	erythropoietin	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	produces	produce	VBZ	VBZ	_	8	conj	_	_
19	platelet-like	platelet-like	JJ	JJ	_	20	amod	_	_
20	particles	particle	NNS	NNS	_	18	dobj	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	August	August	NNP	NNP	_	7	nmod	_	_
3	,	,	,	,	_	2	punct	_	_
4	1992	1992	CD	CD	_	2	amod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	established	establish	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	leukemic	leukemic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	7	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NS-Meg	ns-meg	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	from	from	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	patient	patient	NN	NN	_	7	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	megakaryoblastic	megakaryoblastic	JJ	JJ	_	20	amod	_	_
20	transformation	transformation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	Philadelphia	philadelphia	NN	NN	_	26	compound	_	_
23	chromosome-positive	chromosome-positive	JJ	JJ	_	26	amod	_	_
24	chronic	chronic	JJ	JJ	_	26	amod	_	_
25	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
26	leukemia	leukemia	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NS-Meg	ns-meg	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	positive	positive	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	alpha-naphthyl	alpha-naphthyl	JJ	JJ	_	9	amod	_	_
8	acetate	acetate	NN	NN	_	9	compound	_	_
9	esterase	esterase	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	periodic	periodic	JJ	JJ	_	12	amod	_	_
12	acid-Schiff	acid-schiff	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PAS	pas	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	staining	staining	NN	NN	_	9	dep	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	for	for	IN	IN	_	19	case	_	_
19	surface	surface	NN	NN	_	9	conj	_	_
20	CD4	cd4	NN	NN	_	19	dep	_	_
21	,	,	,	,	_	19	punct	_	_
22	CD7	cd7	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	CD13	cd13	NN	NN	_	19	conj	_	_
25	,	,	,	,	_	19	punct	_	_
26	CD34	cd34	NN	NN	_	19	conj	_	_
27	,	,	,	,	_	19	punct	_	_
28	CD41a	cd41a	NN	NN	_	19	conj	_	_
29	,	,	,	,	_	19	punct	_	_
30	and	and	CC	CC	_	19	cc	_	_
31	glycophorin	glycophorin	NN	NN	_	33	compound	_	_
32	A	a	NN	NN	_	33	compound	_	_
33	antigens	antigen	NNS	NNS	_	19	conj	_	_
34	.	.	.	.	_	5	punct	_	_

1	Ultrastructurally	ultrastructurally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	alpha-granules	alpha-granule	NNS	NNS	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	demarcation	demarcation	NN	NN	_	9	compound	_	_
9	membranes	membrane	NNS	NNS	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	platelet	platelet	NN	NN	_	13	compound	_	_
13	peroxidase	peroxidase	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	6	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NS-Meg	ns-meg	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	spontaneously	spontaneously	RB	RB	_	5	advmod	_	_
5	produced	produce	VBD	VBD	_	0	root	_	_
6	platelet-like	platelet-like	JJ	JJ	_	7	amod	_	_
7	particles	particle	NNS	NNS	_	5	dobj	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	contained	contain	VBD	VBD	_	7	acl:relcl	_	_
10	alpha-granules	alpha-granule	NNS	NNS	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	mitochondria	mitochondria	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	dense	dense	JJ	JJ	_	15	amod	_	_
15	bodies	body	NNS	NNS	_	10	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	strongly	strongly	RB	RB	_	18	advmod	_	_
18	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
19	platelet	platelet	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	Erythropoietin	erythropoietin	NN	NN	_	20	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Epo	epo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	9	amod	_	_
7	colony	colony	NN	NN	_	9	compound	_	_
8	stimulating	stimulating	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	1	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GM-CSF	gm-csf	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	1	punct	_	_
14	and	and	CC	CC	_	1	cc	_	_
15	interleukin	interleukin	NN	NN	_	1	conj	_	_
16	3	3	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL-3	il-3	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	promoted	promote	VBD	VBD	_	0	root	_	_
21	the	the	DT	DT	_	22	det	_	_
22	growth	growth	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NS-Meg	ns-meg	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	20	punct	_	_

1	Phorbol-12-myristate-13-acetate	phorbol-12-myristate-13-acetate	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	CD41a	cd41a	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CD61	cd61	NN	NN	_	7	conj	_	_
10	antigens	antigen	NNS	NNS	_	7	dep	_	_
11	.	.	.	.	_	2	punct	_	_

1	Ten-day	ten-day	JJ	JJ	_	2	amod	_	_
2	exposure	exposure	NN	NN	_	5	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	Epo	epo	NN	NN	_	2	nmod	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	mature	mature	JJ	JJ	_	7	amod	_	_
7	erythroblasts	erythroblast	NNS	NNS	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	red	red	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	conj	_	_
11	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	benzidine-positive	benzidine-positive	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	positive	positive	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	hemoglobin	hemoglobin	NN	NN	_	9	compound	_	_
8	F	f	NN	NN	_	9	compound	_	_
9	staining	staining	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Untreated	untreated	JJ	JJ	_	3	amod	_	_
2	NS-Meg	ns-meg	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	expressed	express	VBD	VBD	_	0	root	_	_
5	mRNA	mrna	NN	NN	_	4	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Epo	epo	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	EpoR	epor	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	for	for	IN	IN	_	15	case	_	_
15	GATA-1	gata-1	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	for	for	IN	IN	_	19	case	_	_
19	alpha	alpha	NN	NN	_	9	conj	_	_
20	1	1	CD	CD	_	19	nummod	_	_
21	,	,	,	,	_	19	punct	_	_
22	alpha	alpha	NN	NN	_	19	conj	_	_
23	2	2	CD	CD	_	22	nummod	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	gamma	gamma	NN	NN	_	19	conj	_	_
26	globin	globin	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	19	dep	_	_
28	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	NS-Meg	ns-meg	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	undergo	undergo	VBP	VBP	_	3	ccomp	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	megakaryocytic	megakaryocytic	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	erythroid	erythroid	JJ	JJ	_	12	conj	_	_
15	lineages	lineage	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	line	line	NN	NN	_	9	nsubj	_	_
4	should	should	MD	MD	_	9	aux	_	_
5	be	be	VB	VB	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	useful	useful	JJ	JJ	_	9	amod	_	_
9	tool	tool	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	investigation	investigation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	megakaryocytic	megakaryocytic	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	erythroid	erythroid	JJ	JJ	_	15	conj	_	_
18	maturation	maturation	NN	NN	_	15	dep	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	shared	shared	JJ	JJ	_	6	amod	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	motifs	motif	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	common	common	JJ	JJ	_	10	amod	_	_
9	Stat	stat	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	6	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	generation	generation	NN	NN	_	2	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cytokine	cytokine	NN	NN	_	13	nmod	_	_
16	pleiotropy	pleiotropy	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	redundancy	redundancy	NN	NN	_	15	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	13	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	IL-4	il-4	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	IL-7	il-7	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	IL-13	il-13	NN	NN	_	20	conj	_	_
27	,	,	,	,	_	20	punct	_	_
28	and	and	CC	CC	_	20	cc	_	_
29	IL-15	il-15	NN	NN	_	20	conj	_	_
30	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	bases	basis	NNS	NNS	_	2	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	cytokine	cytokine	NN	NN	_	5	nmod	_	_
8	redundancy	redundancy	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	pleiotropy	pleiotropy	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	compared	compare	VBN	VBN	_	2	parataxis	_	_
15	the	the	DT	DT	_	17	det	_	_
16	Stat	stat	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	14	dobj	_	_
18	activated	activate	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PBLs	pbl	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	by	by	IN	IN	_	27	case	_	_
27	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	shared	shared	JJ	JJ	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	distinct	distinct	JJ	JJ	_	29	conj	_	_
32	actions	action	NNS	NNS	_	29	dep	_	_
33	.	.	.	.	_	2	punct	_	_

1	Interleukin-2	interleukin-2	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-2	il-2	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	rapidly	rapidly	RB	RB	_	6	advmod	_	_
6	activated	activate	VBD	VBD	_	0	root	_	_
7	Stat5	stat5	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	fresh	fresh	JJ	JJ	_	10	amod	_	_
10	PBL	pbl	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	Stat3	stat3	NN	NN	_	7	conj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Stat5	stat5	NN	NN	_	13	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	preactivated	preactivated	JJ	JJ	_	18	amod	_	_
18	PBL	pbl	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	IL-7	il-7	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-15	il-15	NN	NN	_	1	conj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	same	same	JJ	JJ	_	7	amod	_	_
7	complexes	complex	NNS	NNS	_	4	dobj	_	_
8	as	as	IN	IN	_	9	case	_	_
9	IL-2	il-2	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	feature	feature	NN	NN	_	4	dep	_	_
13	explained	explain	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	existence	existence	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	similar	similar	JJ	JJ	_	20	amod	_	_
19	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	20	amod	_	_
20	motifs	motif	NNS	NNS	_	16	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cytoplasmic	cytoplasmic	JJ	JJ	_	24	amod	_	_
24	domains	domain	NNS	NNS	_	16	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	IL-2R	il-2r	NN	NN	_	27	compound	_	_
27	beta	beta	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	IL-7R	il-7r	NN	NN	_	27	conj	_	_
30	that	that	WDT	WDT	_	32	nsubj	_	_
31	can	can	MD	MD	_	32	aux	_	_
32	serve	serve	VB	VB	_	24	acl:relcl	_	_
33	as	as	IN	IN	_	35	case	_	_
34	docking	docking	NN	NN	_	35	compound	_	_
35	sites	site	NNS	NNS	_	32	nmod	_	_
36	for	for	IN	IN	_	38	case	_	_
37	Stat	stat	NN	NN	_	38	compound	_	_
38	proteins	protein	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	IL-13	il-13	NN	NN	_	2	nsubj	_	_
2	Induced	induce	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	same	same	JJ	JJ	_	5	amod	_	_
5	complexes	complex	NNS	NNS	_	2	dobj	_	_
6	as	as	IN	IN	_	7	case	_	_
7	IL-4	il-4	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	a	a	DT	DT	_	10	det	_	_
10	finding	finding	NN	NN	_	2	dep	_	_
11	explained	explain	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	our	we	PRP$	PRP$	_	14	nmod:poss	_	_
14	studies	study	NNS	NNS	_	11	nmod	_	_
15	implicating	implicate	VBG	VBG	_	14	acl	_	_
16	IL-4R	il-4r	NN	NN	_	15	dobj	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	shared	shared	JJ	JJ	_	20	amod	_	_
20	component	component	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	single	single	JJ	JJ	_	7	amod	_	_
7	cytokine	cytokine	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	activate	activate	VB	VB	_	3	ccomp	_	_
10	different	different	JJ	JJ	_	11	amod	_	_
11	combinations	combination	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Stat	stat	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	under	under	IN	IN	_	18	case	_	_
16	different	different	JJ	JJ	_	18	amod	_	_
17	physiological	physiological	JJ	JJ	_	16	dep	_	_
18	conditions	condition	NNS	NNS	_	9	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	indicate	indicate	VBP	VBP	_	3	conj	_	_
23	two	two	CD	CD	_	24	nummod	_	_
24	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	which	which	WDT	WDT	_	30	nmod	_	_
27	distinct	distinct	JJ	JJ	_	28	amod	_	_
28	cytokines	cytokine	NNS	NNS	_	30	nsubj	_	_
29	can	can	MD	MD	_	30	aux	_	_
30	activate	activate	VB	VB	_	24	acl:relcl	_	_
31	the	the	DT	DT	_	34	det	_	_
32	same	same	JJ	JJ	_	34	amod	_	_
33	Stat	stat	NN	NN	_	34	compound	_	_
34	protein	protein	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	roles	role	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	in	in	FW	FW	_	8	compound	_	_
5	vivo	vivo	FW	FW	_	8	compound	_	_
6	footprinted	footprint	VBN	VBN	_	8	amod	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	motifs	motif	NNS	NNS	_	2	nmod	_	_
9	within	within	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	alpha-globin	alpha-globin	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Erythroid	erythroid	JJ	JJ	_	2	amod	_	_
2	lineage	lineage	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	developmental	developmental	JJ	JJ	_	5	amod	_	_
5	stage	stage	NN	NN	_	2	conj	_	_
6	specificities	specificity	NNS	NNS	_	2	dep	_	_
7	.	.	.	.	_	2	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	alpha-like	alpha-like	JJ	JJ	_	8	amod	_	_
7	globin	globin	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	embryonic	embryonic	JJ	JJ	_	11	amod	_	_
11	zeta	zeta	NN	NN	_	8	appos	_	_
12	2	2	CD	CD	_	11	nummod	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	adult	adult	JJ	JJ	_	15	amod	_	_
15	alpha	alpha	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	during	during	IN	IN	_	19	case	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	development	development	NN	NN	_	2	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	distal	distal	JJ	JJ	_	25	amod	_	_
25	enhancer	enhancer	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	HS-40	hs-40	NN	NN	_	25	appos	_	_
28	.	.	.	.	_	21	punct	_	_

1	Previous	previous	JJ	JJ	_	4	amod	_	_
2	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	HS-40	hs-40	NN	NN	_	9	nsubj	_	_
9	consists	consist	VBZ	VBZ	_	6	ccomp	_	_
10	of	of	IN	IN	_	15	case	_	_
11	multiple	multiple	JJ	JJ	_	15	amod	_	_
12	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	9	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	occupied	occupy	VBN	VBN	_	15	acl:relcl	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vivo	vivo	FW	FW	_	18	advmod	_	_
21	in	in	IN	IN	_	28	case	_	_
22	an	a	DT	DT	_	28	det	_	_
23	erythroid	erythroid	JJ	JJ	_	24	dep	_	_
24	lineage-	lineage-	NN	NN	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	developmental	developmental	JJ	JJ	_	27	amod	_	_
27	stage-specific	stage-specific	JJ	JJ	_	24	conj	_	_
28	manner	manner	NN	NN	_	18	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	systematically	systematically	RB	RB	_	4	advmod	_	_
4	analyzed	analyze	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	roles	role	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	these	these	DT	DT	_	12	det	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	motifs	motif	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HS-40	hs-40	NN	NN	_	12	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	site-directed	site-directed	JJ	JJ	_	17	amod	_	_
17	mutagenesis	mutagenesis	NN	NN	_	4	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	transient	transient	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	17	conj	_	_
21	assay	assay	NN	NN	_	17	dep	_	_
22	in	in	IN	IN	_	25	case	_	_
23	erythroid	erythroid	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	cultures	culture	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Three	three	CD	CD	_	17	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	these	these	DT	DT	_	6	det	_	_
4	HS-40	hs-40	NN	NN	_	6	compound	_	_
5	enhancer	enhancer	NN	NN	_	6	compound	_	_
6	motifs	motif	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	5'NF-E2/AP1	5'nf-e2/ap1	NN	NN	_	1	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	GT	gt	NN	NN	_	8	conj	_	_
11	II	ii	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	GATA-1(c)	gata-1(c)	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	1	punct	_	_
16	positively	positively	RB	RB	_	17	advmod	_	_
17	regulate	regulate	VBP	VBP	_	0	root	_	_
18	the	the	DT	DT	_	22	det	_	_
19	zeta	zeta	NN	NN	_	21	compound	_	_
20	2-globin	2-globin	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	17	dobj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	embryonic/fetal	embryonic/fetal	JJ	JJ	_	27	amod	_	_
25	erythroid	erythroid	JJ	JJ	_	27	amod	_	_
26	K562	k562	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	the	the	DT	DT	_	33	det	_	_
30	adult	adult	JJ	JJ	_	32	amod	_	_
31	alpha-globin	alpha-globin	NN	NN	_	32	compound	_	_
32	promoter	promoter	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	22	conj	_	_
34	in	in	IN	IN	_	38	case	_	_
35	adult	adult	JJ	JJ	_	38	amod	_	_
36	erythroid	erythroid	JJ	JJ	_	38	amod	_	_
37	MEL	mel	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	33	nmod	_	_
39	.	.	.	.	_	17	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	3'NF-E2/AP1	3'nf-e2/ap1	NN	NN	_	8	compound	_	_
8	motif	motif	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	able	able	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	exert	exert	VB	VB	_	10	xcomp	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	positive	positive	JJ	JJ	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	negative	negative	JJ	JJ	_	14	conj	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	14	dep	_	_
19	on	on	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	zeta	zeta	NN	NN	_	23	compound	_	_
22	2-globin	2-globin	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	12	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	K562	k562	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	12	nmod	_	_
28	,	,	,	,	_	10	punct	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	this	this	DT	DT	_	32	det	_	_
31	dual	dual	JJ	JJ	_	32	amod	_	_
32	function	function	NN	NN	_	33	nsubj	_	_
33	appears	appear	VBZ	VBZ	_	10	conj	_	_
34	to	to	TO	TO	_	36	mark	_	_
35	be	be	VB	VB	_	36	auxpass	_	_
36	modulated	modulate	VBN	VBN	_	33	xcomp	_	_
37	through	through	IN	IN	_	39	case	_	_
38	differential	differential	JJ	JJ	_	39	amod	_	_
39	binding	binding	NN	NN	_	36	nmod	_	_
40	of	of	IN	IN	_	44	case	_	_
41	the	the	DT	DT	_	44	det	_	_
42	ubiquitous	ubiquitous	JJ	JJ	_	44	amod	_	_
43	AP1	ap1	NN	NN	_	44	compound	_	_
44	factors	factor	NNS	NNS	_	39	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	the	the	DT	DT	_	49	det	_	_
47	erythroid-enriched	erythroid-enriched	JJ	JJ	_	49	amod	_	_
48	NF-E2	nf-e2	NN	NN	_	49	compound	_	_
49	factor	factor	NN	NN	_	44	conj	_	_
50	.	.	.	.	_	10	punct	_	_

1	Mutation	mutation	NN	NN	_	15	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	GATA-1(d)	gata-1(d)	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	exhibits	exhibit	VBZ	VBZ	_	5	acl:relcl	_	_
9	an	a	DT	DT	_	13	det	_	_
10	adult	adult	JJ	JJ	_	13	amod	_	_
11	erythroid-specific	erythroid-specific	JJ	JJ	_	13	amod	_	_
12	genomic	genomic	JJ	JJ	_	13	amod	_	_
13	footprint	footprint	NN	NN	_	8	dobj	_	_
14	,	,	,	,	_	1	punct	_	_
15	decreases	decrease	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	19	det	_	_
17	HS-40	hs-40	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	15	dobj	_	_
20	in	in	IN	IN	_	24	case	_	_
21	dimethyl	dimethyl	JJ	JJ	_	24	amod	_	_
22	sulfoxide-induced	sulfoxide-induced	JJ	JJ	_	24	amod	_	_
23	MEL	mel	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	15	nmod	_	_
25	but	but	CC	CC	_	24	cc	_	_
26	not	not	RB	RB	_	29	neg	_	_
27	in	in	IN	IN	_	29	case	_	_
28	K562	k562	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	conj	_	_
30	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	defined	define	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	roles	role	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	HS-40	hs-40	NN	NN	_	12	compound	_	_
12	motifs	motif	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	remarkable	remarkable	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	13	nsubj	_	_
4	between	between	IN	IN	_	7	case	_	_
5	genomic	genomic	JJ	JJ	_	7	amod	_	_
6	footprinting	footprinting	NN	NN	_	7	compound	_	_
7	data	datum	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	mutagenesis	mutagenesis	NN	NN	_	11	compound	_	_
11	results	result	NNS	NNS	_	7	conj	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	suggests	suggest	VBZ	VBZ	_	0	root	_	_
14	that	that	IN	IN	_	29	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
17	lineage-	lineage-	NN	NN	_	29	nsubjpass	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	developmental	developmental	JJ	JJ	_	20	amod	_	_
20	stage-specific	stage-specific	JJ	JJ	_	17	conj	_	_
21	regulation	regulation	NN	NN	_	17	dep	_	_
22	of	of	IN	IN	_	26	case	_	_
23	human	human	JJ	JJ	_	26	amod	_	_
24	alpha-like	alpha-like	JJ	JJ	_	26	amod	_	_
25	globin	globin	NN	NN	_	26	compound	_	_
26	promoters	promoter	NNS	NNS	_	17	nmod	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	indeed	indeed	RB	RB	_	29	advmod	_	_
29	modulated	modulate	VBN	VBN	_	13	ccomp	_	_
30	by	by	IN	IN	_	32	case	_	_
31	stable	stable	JJ	JJ	_	32	amod	_	_
32	binding	binding	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	specific	specific	JJ	JJ	_	36	amod	_	_
35	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
36	factors	factor	NNS	NNS	_	32	nmod	_	_
37	in	in	FW	FW	_	38	compound	_	_
38	vivo	vivo	FW	FW	_	29	advmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	major	major	JJ	JJ	_	7	amod	_	_
5	positive	positive	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	1	nmod	_	_
8	located	located	JJ	JJ	_	9	amod	_	_
9	5'	5'	JJ	JJ	_	7	amod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	zeta-globin	zeta-globin	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	zeta-globin	zeta-globin	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	studied	study	VBN	VBN	_	0	root	_	_
9	using	use	VBG	VBG	_	8	xcomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	series	series	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	zeta-globin	zeta-globin	NN	NN	_	16	compound	_	_
14	promoter	promoter	NN	NN	_	16	compound	_	_
15	deletion	deletion	NN	NN	_	16	compound	_	_
16	constructs	construct	NNS	NNS	_	11	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	drive	drive	VB	VB	_	11	acl	_	_
19	luciferase	luciferase	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	26	case	_	_
22	transiently	transiently	RB	RB	_	26	advmod	_	_
23	transfected	transfect	VBN	VBN	_	26	amod	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	erythroleukemia	erythroleukemia	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoters	promoter	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	without	without	IN	IN	_	6	case	_	_
6	enhancers	enhancer	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	or	or	CC	CC	_	6	cc	_	_
9	with	with	IN	IN	_	10	case	_	_
10	enhancers	enhancer	NNS	NNS	_	6	conj	_	_
11	derived	derive	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	beta-globin	beta-globin	NN	NN	_	17	compound	_	_
15	locus	locus	NN	NN	_	17	compound	_	_
16	control	control	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	alpha-globin	alpha-globin	NN	NN	_	22	compound	_	_
21	HS-40	hs-40	NN	NN	_	22	compound	_	_
22	enhancer	enhancer	NN	NN	_	10	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	transfected	transfect	VBN	VBN	_	16	advcl	_	_
3	into	into	IN	IN	_	5	case	_	_
4	K562	k562	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	express	express	VBP	VBP	_	5	acl:relcl	_	_
9	zeta-globin	zeta-globin	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	16	punct	_	_
11	comparable	comparable	JJ	JJ	_	12	amod	_	_
12	amounts	amount	NNS	NNS	_	16	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	activity	activity	NN	NN	_	12	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	obtained	obtain	VBN	VBN	_	0	root	_	_
17	from	from	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	-557	-557	CD	CD	_	23	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	-417	-417	CD	CD	_	19	conj	_	_
22	zeta-luciferase	zeta-luciferase	NN	NN	_	23	compound	_	_
23	constructs	construct	NNS	NNS	_	16	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	27	det	_	_
26	alpha-luciferase	alpha-luciferase	NN	NN	_	27	compound	_	_
27	constructs	construct	NNS	NNS	_	23	conj	_	_
28	when	when	WRB	WRB	_	37	advmod	_	_
29	no	no	DT	DT	_	30	neg	_	_
30	enhancers	enhancer	NNS	NNS	_	37	nsubjpass	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	35	det	_	_
33	alpha-globin	alpha-globin	NN	NN	_	35	compound	_	_
34	locus	locus	NN	NN	_	35	compound	_	_
35	enhancers	enhancer	NNS	NNS	_	30	conj	_	_
36	were	be	VBD	VBD	_	37	auxpass	_	_
37	used	use	VBN	VBN	_	16	advcl	_	_
38	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	constructs	construct	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	transfected	transfect	VBN	VBN	_	25	advcl	_	_
6	into	into	IN	IN	_	8	case	_	_
7	OCIM1	ocim1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	13	nsubj	_	_
11	do	do	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	express	express	VB	VB	_	8	acl:relcl	_	_
14	zeta-globin	zeta-globin	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	25	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	zeta-globin	zeta-globin	NN	NN	_	18	compound	_	_
18	promoters	promoter	NNS	NNS	_	25	nsubj	_	_
19	were	be	VBD	VBD	_	25	cop	_	_
20	at	at	IN	IN	_	21	case	_	_
21	best	best	RB	RB	_	25	advmod	_	_
22	20	20	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	25	dep	_	_
24	as	as	IN	IN	_	25	dep	_	_
25	active	active	JJ	JJ	_	0	root	_	_
26	as	as	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	alpha-globin	alpha-globin	NN	NN	_	29	compound	_	_
29	promoters	promoter	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	25	punct	_	_

1	When	when	WRB	WRB	_	15	advmod	_	_
2	sequences	sequence	NNS	NNS	_	15	nsubjpass	_	_
3	from	from	IN	IN	_	2	amod	_	_
4	-417	-417	CD	CD	_	2	nummod	_	_
5	to	to	TO	TO	_	2	dep	_	_
6	-207	-207	CD	CD	_	2	nummod	_	_
7	5'	5'	JJ	JJ	_	2	amod	_	_
8	to	to	TO	TO	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	zeta-globin	zeta-globin	NN	NN	_	13	compound	_	_
11	mRNA	mrna	NN	NN	_	13	compound	_	_
12	cap	cap	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	2	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	deleted	delete	VBN	VBN	_	27	advcl	_	_
16	,	,	,	,	_	27	punct	_	_
17	up	up	IN	IN	_	19	dep	_	_
18	to	to	TO	TO	_	17	mwe	_	_
19	95	95	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	27	nsubjpass	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	zeta-globin	zeta-globin	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	20	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	lost	lose	VBN	VBN	_	0	root	_	_
28	in	in	IN	IN	_	30	case	_	_
29	K562	k562	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	27	punct	_	_

1	Reinsertion	reinsertion	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	into	into	IN	IN	_	7	case	_	_
6	zeta-luciferase	zeta-luciferase	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	1	nmod	_	_
8	missing	miss	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	13	det	_	_
10	-417	-417	CD	CD	_	13	nummod	_	_
11	to	to	TO	TO	_	13	dep	_	_
12	-207	-207	CD	CD	_	13	nummod	_	_
13	region	region	NN	NN	_	8	dobj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	sequences	sequence	NNS	NNS	_	18	nsubj	_	_
18	lack	lack	VBP	VBP	_	14	ccomp	_	_
19	classical	classical	JJ	JJ	_	21	amod	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	14	punct	_	_

1	Point	point	NN	NN	_	2	compound	_	_
2	mutation	mutation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	GATA-1	gata-1	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	at	at	IN	IN	_	8	case	_	_
8	-230	-230	CD	CD	_	2	nmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	37	37	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Point	point	NN	NN	_	2	compound	_	_
2	mutation	mutation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	CCACC	ccacc	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	at	at	IN	IN	_	8	case	_	_
8	-240	-240	CD	CD	_	2	nmod	_	_
9	had	have	VBD	VBD	_	0	root	_	_
10	no	no	DT	DT	_	11	neg	_	_
11	effect	effect	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	indicated	indicate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	-230	-230	CD	CD	_	10	nummod	_	_
9	GATA-1	gata-1	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	11	nsubj	_	_
11	has	have	VBZ	VBZ	_	5	ccomp	_	_
12	a	a	DT	DT	_	15	det	_	_
13	relatively	relatively	RB	RB	_	14	advmod	_	_
14	low	low	JJ	JJ	_	15	amod	_	_
15	affinity	affinity	NN	NN	_	11	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	GATA-1	gata-1	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	strong	strong	JJ	JJ	_	10	amod	_	_
9	positive-acting	positive-acting	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	located	located	JJ	JJ	_	10	amod	_	_
13	between	between	IN	IN	_	17	case	_	_
14	-417	-417	CD	CD	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	-207	-207	CD	CD	_	14	conj	_	_
17	bp	bp	NN	NN	_	12	nmod	_	_
18	5'	5'	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	zeta-globin	zeta-globin	NN	NN	_	24	compound	_	_
22	mRNA	mrna	NN	NN	_	24	compound	_	_
23	cap	cap	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	17	nmod	_	_
25	,	,	,	,	_	3	punct	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	necessary	necessary	JJ	JJ	_	3	dep	_	_
28	for	for	IN	IN	_	31	case	_	_
29	high-level	high-level	JJ	JJ	_	31	amod	_	_
30	promoter	promoter	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	K562	k562	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	GATA-1	gata-1	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	additional	additional	JJ	JJ	_	8	amod	_	_
7	unknown	unknown	JJ	JJ	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	4	conj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	maximal	maximal	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	4	nmod	_	_
8	C-alpha	c-alpha	NN	NN	_	7	dep	_	_
9	,	,	,	,	_	7	punct	_	_
10	-epsilon	-epsilon	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	-zeta	-zeta	NN	NN	_	7	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	4	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	multiple	multiple	JJ	JJ	_	5	amod	_	_
5	isotypes	isotype	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	C	c	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PKC	pkc	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	although	although	IN	IN	_	18	dep	_	_
15	it	it	PRP	PRP	_	18	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	well	well	RB	RB	_	18	advmod	_	_
18	accepted	accept	VBN	VBN	_	3	conj	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	PKCs	pkc	NNS	NNS	_	21	nsubj	_	_
21	have	have	VBP	VBP	_	18	ccomp	_	_
22	an	a	DT	DT	_	24	det	_	_
23	important	important	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	21	nmod	_	_
29	,	,	,	,	_	18	punct	_	_
30	little	little	JJ	JJ	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	known	know	VBN	VBN	_	18	parataxis	_	_
33	about	about	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	function	function	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	individual	individual	JJ	JJ	_	39	amod	_	_
38	PKC	pkc	NN	NN	_	39	compound	_	_
39	isotypes	isotype	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	issue	issue	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	mutationally	mutationally	RB	RB	_	7	advmod	_	_
7	active	active	JJ	JJ	_	8	amod	_	_
8	PKC-alpha	pkc-alpha	NN	NN	_	16	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	-epsilon	-epsilon	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	-zeta	-zeta	NN	NN	_	8	conj	_	_
14	have	have	VBP	VBP	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	transfected	transfect	VBN	VBN	_	2	parataxis	_	_
17	into	into	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	consequences	consequence	NNS	NNS	_	27	nsubj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	determined	determine	VBN	VBN	_	16	conj	_	_
28	.	.	.	.	_	2	punct	_	_

1	p21ras	p21ras	NN	NN	_	2	nsubj	_	_
2	plays	play	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	essential	essential	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Accordingly	accordingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	constitutively	constitutively	RB	RB	_	9	advmod	_	_
8	active	active	JJ	JJ	_	9	amod	_	_
9	PKCs	pkc	NNS	NNS	_	4	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	compared	compare	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effects	effect	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	mutationally	mutationally	RB	RB	_	17	advmod	_	_
17	activated	activate	VBN	VBN	_	18	amod	_	_
18	p21ras	p21ras	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	PKC-epsilon	pkc-epsilon	NN	NN	_	18	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	,	,	,	,	_	5	punct	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	lesser	lesser	JJR	JJR	_	11	amod	_	_
11	extent	extent	NN	NN	_	5	conj	_	_
12	PKC-alpha	pkc-alpha	NN	NN	_	5	dep	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	12	cc	_	_
15	-zeta	-zeta	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	regulate	regulate	VB	VB	_	3	ccomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	dobj	_	_
22	AP-1	ap-1	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
25	factor	factor	NN	NN	_	29	compound	_	_
26	of	of	IN	IN	_	29	amod	_	_
27	activated	activate	VBN	VBN	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	NF-AT-1	nf-at-1	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PKC-epsilon	pkc-epsilon	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	induce	induce	VB	VB	_	2	acl	_	_
7	transactivation	transactivation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-AT-1	nf-at-1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	AP-1	ap-1	NN	NN	_	9	conj	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	similar	similar	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	stimulatory	stimulatory	JJ	JJ	_	17	amod	_	_
17	effect	effect	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	constitutively	constitutively	RB	RB	_	22	advmod	_	_
21	activated	activate	VBN	VBN	_	22	amod	_	_
22	p21ras	p21ras	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	PKC-epsilon	pkc-epsilon	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	but	but	CC	CC	_	4	cc	_	_
4	not	not	RB	RB	_	1	cc	_	_
5	PKC-alpha	pkc-alpha	NN	NN	_	1	conj	_	_
6	nor	nor	CC	CC	_	5	cc	_	_
7	activated	activated	JJ	JJ	_	8	amod	_	_
8	p21ras	p21ras	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	1	punct	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	able	able	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	11	xcomp	_	_
14	NF-KB	nf-kb	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	11	punct	_	_

1	Phorbol	phorbol	NN	NN	_	2	compound	_	_
2	esters	ester	NNS	NNS	_	3	nsubj	_	_
3	induce	induce	VBP	VBP	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD69	cd69	NN	NN	_	4	nmod	_	_
7	whereas	whereas	IN	IN	_	16	mark	_	_
8	none	none	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	PKC	pkc	NN	NN	_	13	compound	_	_
13	isotypes	isotype	NNS	NNS	_	8	nmod	_	_
14	tested	test	VBN	VBN	_	13	acl	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	able	able	JJ	JJ	_	3	advcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	have	have	VB	VB	_	16	xcomp	_	_
19	this	this	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	Src	src	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	p21ras	p21ras	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	able	able	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	induce	induce	VB	VB	_	6	xcomp	_	_
9	CD69	cd69	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	selective	selective	JJ	JJ	_	5	amod	_	_
5	functions	function	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	different	different	JJ	JJ	_	9	amod	_	_
8	PKC	pkc	NN	NN	_	9	compound	_	_
9	isotypes	isotype	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	14	nsubj	_	_
5	comparing	compare	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	activated	activate	VBN	VBN	_	10	amod	_	_
10	Ras	ras	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	PKC	pkc	NN	NN	_	13	compound	_	_
13	mutants	mutant	NNS	NNS	_	10	conj	_	_
14	suggest	suggest	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	24	mark	_	_
16	PKC-alpha	pkc-alpha	NN	NN	_	24	nsubj	_	_
17	,	,	,	,	_	16	punct	_	_
18	p21ras	p21ras	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	PKC-epsilon	pkc-epsilon	NN	NN	_	16	conj	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	positioned	positioned	JJ	JJ	_	14	ccomp	_	_
25	linearly	linearly	RB	RB	_	24	advmod	_	_
26	on	on	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	single	single	JJ	JJ	_	31	amod	_	_
29	signal	signal	NN	NN	_	31	compound	_	_
30	transduction	transduction	NN	NN	_	31	compound	_	_
31	pathway	pathway	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	transcription	transcription	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	5	case	_	_
5	binding	binding	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-E1	nf-e1	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	YY1	yy1	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	to	to	TO	TO	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	newly	newly	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	15	amod	_	_
15	element	element	NN	NN	_	5	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	first	first	JJ	JJ	_	19	amod	_	_
19	exon	exon	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	DR	dr	NN	NN	_	25	compound	_	_
24	alpha	alpha	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	unrecognized	unrecognized	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	26	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	located	located	JJ	JJ	_	4	amod	_	_
7	downstream	downstream	RB	RB	_	6	advmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	start	start	NN	NN	_	13	compound	_	_
11	site	site	NN	NN	_	13	compound	_	_
12	of	of	IN	IN	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	first	first	JJ	JJ	_	17	amod	_	_
17	exon	exon	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	DR	dr	NN	NN	_	22	compound	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	4	punct	_	_
24	has	have	VBZ	VBZ	_	26	aux	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	defined	define	VBN	VBN	_	0	root	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	enhances	enhance	VBZ	VBZ	_	26	dep	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	28	iobj	_	_
31	up	up	IN	IN	_	33	amod	_	_
32	to	to	TO	TO	_	33	dep	_	_
33	eightfold	eightfold	JJ	JJ	_	28	dobj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	position-dependent	position-dependent	JJ	JJ	_	37	amod	_	_
37	manner	manner	NN	NN	_	28	nmod	_	_
38	.	.	.	.	_	26	punct	_	_

1	Mutations	mutation	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	abolished	abolish	VBD	VBD	_	0	root	_	_
7	binding	binding	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	B	b	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	extract	extract	NN	NN	_	7	nmod	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	decreased	decrease	VBD	VBD	_	6	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activity	activity	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	DR	dr	NN	NN	_	26	compound	_	_
25	alpha	alpha	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	21	nmod	_	_
27	to	to	TO	TO	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	basal	basal	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	19	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Significant	significant	JJ	JJ	_	3	amod	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	homology	homology	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	element	element	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	DNA	dna	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	dep	_	_
14	DR	dr	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	DP	dp	NN	NN	_	15	conj	_	_
18	alpha	alpha	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	-beta	-beta	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	15	punct	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	DQ	dq	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	15	conj	_	_
25	genes	gene	NNS	NNS	_	15	dep	_	_
26	,	,	,	,	_	8	punct	_	_
27	always	always	RB	RB	_	8	advmod	_	_
28	located	located	JJ	JJ	_	8	xcomp	_	_
29	downstream	downstream	RB	RB	_	28	advmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	transcriptional	transcriptional	JJ	JJ	_	34	amod	_	_
33	start	start	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	dep	_	_
7	DR	dr	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	DP	dp	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	8	conj	_	_
12	element	element	NN	NN	_	8	dep	_	_
13	but	but	CC	CC	_	8	cc	_	_
14	not	not	RB	RB	_	17	neg	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	element	element	NN	NN	_	8	conj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	DQ	dq	NN	NN	_	22	compound	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	5	case	_	_
5	NF-E1	nf-e1	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	YY1	yy1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	26	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	previously	previously	RB	RB	_	5	advmod	_	_
5	identified	identify	VBN	VBN	_	2	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	binding	binding	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	Ig	ig	NN	NN	_	14	compound	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	3'	3'	JJ	JJ	_	14	amod	_	_
14	enhancer	enhancer	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	22	det	_	_
17	Ig	ig	NN	NN	_	22	compound	_	_
18	heavy	heavy	JJ	JJ	_	22	amod	_	_
19	chain	chain	NN	NN	_	22	compound	_	_
20	mu	mu	NN	NN	_	22	compound	_	_
21	E1	e1	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	14	conj	_	_
23	,	,	,	,	_	2	punct	_	_
24	thus	thus	RB	RB	_	26	advmod	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	appears	appear	VBZ	VBZ	_	0	root	_	_
27	to	to	TO	TO	_	30	mark	_	_
28	be	be	VB	VB	_	30	cop	_	_
29	quite	quite	RB	RB	_	30	advmod	_	_
30	important	important	JJ	JJ	_	26	xcomp	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	regulation	regulation	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	39	case	_	_
35	MHC	mhc	NN	NN	_	38	compound	_	_
36	class	class	NN	NN	_	38	compound	_	_
37	II	ii	CD	CD	_	38	nummod	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	26	punct	_	_

1	Growth	growth	NN	NN	_	2	compound	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cellular	cellular	JJ	JJ	_	5	amod	_	_
5	changes	change	NNS	NNS	_	2	conj	_	_
6	during	during	IN	IN	_	7	case	_	_
7	differentiation	differentiation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	prostatic	prostatic	JJ	JJ	_	13	amod	_	_
11	cancer	cancer	NN	NN	_	13	compound	_	_
12	LNCaP	lncap	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	induced	induce	VBN	VBN	_	7	dep	_	_
16	by	by	IN	IN	_	20	case	_	_
17	T	t	NN	NN	_	20	compound	_	_
18	lymphocyte	lymphocyte	JJ	JJ	_	20	amod	_	_
19	-conditioned	-conditioned	JJ	JJ	_	20	amod	_	_
20	medium	medium	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	prostatic	prostatic	JJ	JJ	_	4	amod	_	_
3	epithelial	epithelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
5	from	from	IN	IN	_	10	case	_	_
6	an	a	DT	DT	_	10	det	_	_
7	androgen-dependent	androgen-dependent	JJ	JJ	_	10	amod	_	_
8	LNCaP	lncap	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	4	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	examined	examine	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	conditioned	conditioned	JJ	JJ	_	17	amod	_	_
17	medium	medium	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CM	cm	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	derived	derive	VBN	VBN	_	17	acl	_	_
22	from	from	IN	IN	_	28	case	_	_
23	phytohemagglutinin	phytohemagglutinin	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	PHA	pha	NN	NN	_	28	compound	_	_
26	)	)	-RRB-	-RRB-	_	28	punct	_	_
27	-stimulated	-stimulated	JJ	JJ	_	28	amod	_	_
28	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Addition	addition	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CM	cm	NN	NN	_	1	nmod	_	_
4	caused	cause	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	10	det	_	_
6	greater	greater	JJR	JJR	_	8	advmod	_	_
7	than	than	IN	IN	_	8	advmod	_	_
8	70	70	CD	CD	_	9	dep	_	_
9	%	%	NN	NN	_	10	dep	_	_
10	reduction	reduction	NN	NN	_	4	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	counting	counting	NN	NN	_	4	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	cycle	cycle	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	G1	g1	NN	NN	_	6	compound	_	_
5	phase	phase	NN	NN	_	6	compound	_	_
6	arrest	arrest	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	the	the	DT	DT	_	9	det	_	_
9	clonogenicity	clonogenicity	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	reduced	reduce	VBN	VBN	_	3	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	growth-modulating	growth-modulating	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	dose-dependent	dose-dependent	JJ	JJ	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	not	not	RB	RB	_	5	conj	_	_
8	due	due	JJ	JJ	_	5	dep	_	_
9	to	to	TO	TO	_	10	case	_	_
10	cell	cell	NN	NN	_	8	nmod	_	_
11	lysis	lysis	NN	NN	_	10	dep	_	_
12	or	or	CC	CC	_	10	cc	_	_
13	apoptosis	apoptosis	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	androgen	androgen	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	androgen	androgen	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	2	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	50	50	CD	CD	_	14	dep	_	_
14	%	%	NN	NN	_	15	dep	_	_
15	reduction	reduction	NN	NN	_	11	dobj	_	_
16	,	,	,	,	_	11	punct	_	_
17	underlining	underline	VBG	VBG	_	11	advcl	_	_
18	a	a	DT	DT	_	21	det	_	_
19	proliferation	proliferation	NN	NN	_	21	compound	_	_
20	reduction	reduction	NN	NN	_	21	compound	_	_
21	mechanism	mechanism	NN	NN	_	17	dobj	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	prostate-specific	prostate-specific	JJ	JJ	_	3	amod	_	_
3	antigen	antigen	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PSA	psa	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	downregulated	downregulate	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	75	75	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	8	nmod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	process	process	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	morphology	morphology	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	dendritic	dendritic	JJ	JJ	_	5	amod	_	_
5	processes	process	NNS	NNS	_	3	dobj	_	_
6	extending	extend	VBG	VBG	_	5	acl	_	_
7	from	from	IN	IN	_	8	case	_	_
8	cytoplasm	cytoplasm	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	other	other	JJ	JJ	_	12	amod	_	_
11	neuroendocrine	neuroendocrine	JJ	JJ	_	12	amod	_	_
12	cell	cell	NN	NN	_	8	conj	_	_
13	characteristics	characteristic	NNS	NNS	_	8	dep	_	_
14	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	cytoskeleton	cytoskeleton	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	intracellular	intracellular	JJ	JJ	_	5	conj	_	_
8	proteins	protein	NNS	NNS	_	5	dep	_	_
9	increased	increase	VBD	VBD	_	0	root	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	determined	determine	VBN	VBN	_	9	advcl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	immunostaining	immunostaining	NN	NN	_	11	nmod	_	_
14	on	on	IN	IN	_	15	case	_	_
15	slides	slide	NNS	NNS	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	by	by	IN	IN	_	19	case	_	_
18	ELISA	elisa	NN	NN	_	19	compound	_	_
19	procedures	procedure	NNS	NNS	_	13	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	included	include	VBD	VBD	_	0	root	_	_
3	vimentin	vimentin	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	correlating	correlate	VBG	VBG	_	3	acl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	shape	shape	NN	NN	_	9	compound	_	_
9	changes	change	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	cytokeratins	cytokeratin	NNS	NNS	_	3	conj	_	_
12	8	8	CD	CD	_	11	dep	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	18	18	CD	CD	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	associated	associate	VBN	VBN	_	11	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	differentiated	differentiate	VBN	VBN	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	prostate	prostate	NN	NN	_	23	compound	_	_
23	epithelia	epithelia	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	neuron-specific	neuron-specific	JJ	JJ	_	27	amod	_	_
27	enolase	enolase	NN	NN	_	3	conj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	serotonin	serotonin	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	27	punct	_	_
31	associated	associate	VBN	VBN	_	27	acl	_	_
32	with	with	IN	IN	_	34	case	_	_
33	neuroendocrine	neuroendocrine	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	From	from	IN	IN	_	4	case	_	_
2	these	these	DT	DT	_	4	det	_	_
3	cellular	cellular	JJ	JJ	_	4	amod	_	_
4	changes	change	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	infer	infer	VB	VB	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	growth	growth	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	modulated	modulate	VBN	VBN	_	8	ccomp	_	_
15	along	along	IN	IN	_	17	case	_	_
16	with	with	IN	IN	_	17	case	_	_
17	induction	induction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	terminal	terminal	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	important	important	JJ	JJ	_	5	xcomp	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	providing	provide	VBG	VBG	_	8	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	modulating	modulating	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	growth	growth	NN	NN	_	3	compound	_	_
3	modulator	modulator	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	semipurified	semipurify	VBN	VBN	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	had	have	VBD	VBD	_	5	conj	_	_
8	an	a	DT	DT	_	11	det	_	_
9	estimated	estimate	VBN	VBN	_	11	amod	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	weight	weight	NN	NN	_	7	dobj	_	_
12	13,000	13,000	CD	CD	_	14	compound	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	24,000	24,000	CD	CD	_	15	nummod	_	_
15	Da	da	NN	NN	_	11	dep	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	distinct	distinct	JJ	JJ	_	4	xcomp	_	_
8	from	from	IN	IN	_	9	case	_	_
9	TGF	tgf	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	TNF	tnf	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	some	some	DT	DT	_	17	det	_	_
15	commonly	commonly	RB	RB	_	16	advmod	_	_
16	known	known	JJ	JJ	_	17	amod	_	_
17	lymphokines	lymphokine	NNS	NNS	_	9	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	13	nsubjpass	_	_
3	between	between	IN	IN	_	4	case	_	_
4	lymphoid	lymphoid	JJ	JJ	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	prostatic	prostatic	JJ	JJ	_	4	conj	_	_
7	cells	cell	NNS	NNS	_	4	dep	_	_
8	in	in	IN	IN	_	9	case	_	_
9	growth	growth	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	development	development	NN	NN	_	9	conj	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	described	describe	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Mouse	mouse	NN	NN	_	5	compound	_	_
2	interleukin-2	interleukin-2	NN	NN	_	5	compound	_	_
3	receptor	receptor	NN	NN	_	5	compound	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	Interleukin-1	interleukin-1	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	interleukin-2	interleukin-2	NN	NN	_	1	conj	_	_
4	control	control	VBP	VBP	_	0	root	_	_
5	transcription	transcription	NN	NN	_	4	dobj	_	_
6	via	via	IN	IN	_	9	case	_	_
7	distinct	distinct	JJ	JJ	_	9	amod	_	_
8	cis-acting	cis-acting	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	interleukin-1	interleukin-1	NN	NN	_	11	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-1	il-1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	IL-2	il-2	NN	NN	_	5	conj	_	_
11	control	control	VBP	VBP	_	3	ccomp	_	_
12	IL-2	il-2	NN	NN	_	19	compound	_	_
13	receptor	receptor	NN	NN	_	19	compound	_	_
14	alpha	alpha	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	IL-2R	il-2r	NN	NN	_	19	compound	_	_
17	alpha	alpha	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	11	dobj	_	_
21	in	in	IN	IN	_	26	case	_	_
22	CD4-CD8-	cd4-cd8-	JJ	JJ	_	26	amod	_	_
23	murine	murine	JJ	JJ	_	26	amod	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	lymphocyte	lymphocyte	NN	NN	_	26	compound	_	_
26	precursors	precursor	NNS	NNS	_	11	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	map	map	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	cis-acting	cis-acting	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	3	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	mediate	mediate	VBP	VBP	_	6	acl:relcl	_	_
9	interleukin	interleukin	NN	NN	_	10	compound	_	_
10	responsiveness	responsiveness	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	mouse	mouse	NN	NN	_	16	compound	_	_
14	IL-2R	il-2r	NN	NN	_	16	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	using	use	VBG	VBG	_	3	xcomp	_	_
18	a	a	DT	DT	_	21	det	_	_
19	thymic	thymic	JJ	JJ	_	21	amod	_	_
20	lymphoma-derived	lymphoma-derived	JJ	JJ	_	21	amod	_	_
21	hybridoma	hybridoma	NN	NN	_	17	dobj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PC60	pc60	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	IL-2R	il-2r	NN	NN	_	8	compound	_	_
7	alpha	alpha	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	3	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	IL-1	il-1	NN	NN	_	10	nmod	_	_
13	+	+	CC	CC	_	12	cc	_	_
14	IL-2	il-2	NN	NN	_	12	conj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	biphasic	biphasic	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	IL-1	il-1	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	8	det	_	_
4	rapid	rapid	JJ	JJ	_	8	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	protein	protein	NN	NN	_	7	nmod:npmod	_	_
7	synthesis-independent	synthesis-independent	JJ	JJ	_	4	dep	_	_
8	appearance	appearance	NN	NN	_	2	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	IL-2R	il-2r	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	8	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	blocked	block	VBN	VBN	_	8	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	inhibitors	inhibitor	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	primes	prime	VBZ	VBZ	_	0	root	_	_
4	cells	cell	NNS	NNS	_	3	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	become	become	VB	VB	_	3	advcl	_	_
7	IL-2	il-2	NN	NN	_	8	nmod:npmod	_	_
8	responsive	responsive	JJ	JJ	_	6	xcomp	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	thereby	thereby	RB	RB	_	11	advmod	_	_
11	prepares	prepare	VBZ	VBZ	_	3	conj	_	_
12	the	the	DT	DT	_	14	det	_	_
13	second	second	JJ	JJ	_	14	amod	_	_
14	phase	phase	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	in	in	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	19	nmod	_	_
18	IL-2	il-2	NN	NN	_	19	nsubj	_	_
19	induces	induce	VBZ	VBZ	_	14	acl:relcl	_	_
20	a	a	DT	DT	_	23	det	_	_
21	100-fold	100-fold	RB	RB	_	22	advmod	_	_
22	further	further	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	19	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	IL-2R	il-2r	NN	NN	_	27	compound	_	_
26	alpha	alpha	NN	NN	_	27	compound	_	_
27	transcripts	transcript	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	several	several	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	17	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter-proximal	promoter-proximal	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	IL-2R	il-2r	NN	NN	_	16	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	contribute	contribute	VBP	VBP	_	4	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	IL-1	il-1	NN	NN	_	20	compound	_	_
20	responsiveness	responsiveness	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	most	most	RBS	RBS	_	23	advmod	_	_
23	importantly	importantly	RB	RB	_	20	advmod	_	_
24	an	a	DT	DT	_	27	det	_	_
25	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	20	dep	_	_
28	conserved	conserve	VBN	VBN	_	27	acl	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	dep	_	_
31	human	human	JJ	JJ	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	mouse	mouse	NN	NN	_	31	conj	_	_
34	gene	gene	NN	NN	_	31	dep	_	_
35	.	.	.	.	_	4	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	responsiveness	responsiveness	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	hand	hand	NN	NN	_	9	nmod	_	_
8	,	,	,	,	_	9	punct	_	_
9	depends	depend	VBZ	VBZ	_	0	root	_	_
10	on	on	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	78-nucleotide	78-nucleotide	JJ	JJ	_	13	amod	_	_
13	segment	segment	NN	NN	_	9	nmod	_	_
14	1.3	1.3	CD	CD	_	15	nummod	_	_
15	kilobases	kilobase	NNS	NNS	_	16	nmod:npmod	_	_
16	upstream	upstream	RB	RB	_	13	advmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	major	major	JJ	JJ	_	22	amod	_	_
20	transcription	transcription	NN	NN	_	22	compound	_	_
21	start	start	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	segment	segment	NN	NN	_	3	nsubj	_	_
3	functions	function	VBZ	VBZ	_	0	root	_	_
4	as	as	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	IL-2-inducible	il-2-inducible	JJ	JJ	_	7	amod	_	_
7	enhancer	enhancer	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	lies	lie	VBZ	VBZ	_	3	conj	_	_
10	within	within	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	region	region	NN	NN	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	becomes	become	VBZ	VBZ	_	12	acl:relcl	_	_
15	DNase	dnase	NN	NN	_	17	nmod:npmod	_	_
16	I	i	CD	CD	_	15	nummod	_	_
17	hypersensitive	hypersensitive	JJ	JJ	_	14	xcomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	normal	normal	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	29	nmod	_	_
24	IL-2R	il-2r	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	29	nsubjpass	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	induced	induce	VBN	VBN	_	21	acl:relcl	_	_
30	.	.	.	.	_	3	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	responsiveness	responsiveness	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	three	three	CD	CD	_	6	nummod	_	_
5	distinct	distinct	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	3	dobj	_	_
7	within	within	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	enhancer	enhancer	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	are	be	VBP	VBP	_	7	cop	_	_
5	potential	potential	JJ	JJ	_	7	amod	_	_
6	binding	bind	VBG	VBG	_	7	amod	_	_
7	sites	site	NNS	NNS	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	STAT	stat	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Monocyte	monocyte	NN	NN	_	2	compound	_	_
2	tethering	tethering	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	P-selectin	p-selectin	NN	NN	_	2	nmod	_	_
5	regulates	regulate	VBZ	VBZ	_	0	root	_	_
6	monocyte	monocyte	NN	NN	_	8	compound	_	_
7	chemotactic	chemotactic	JJ	JJ	_	8	amod	_	_
8	protein-1	protein-1	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	tumor	tumor	NN	NN	_	12	compound	_	_
11	necrosis	necrosis	NN	NN	_	12	compound	_	_
12	factor-alpha	factor-alpha	NN	NN	_	8	conj	_	_
13	secretion	secretion	NN	NN	_	8	dep	_	_
14	.	.	.	.	_	5	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	integration	integration	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	translocation	translocation	NN	NN	_	2	conj	_	_
7	-LSB-	-lsb-	-LRB-	-LRB-	_	8	punct	_	_
8	see	see	VB	VB	_	2	dep	_	_
9	comments	comment	NNS	NNS	_	8	dobj	_	_
10	-RSB-	-rsb-	-RRB-	-RRB-	_	8	punct	_	_

1	Adhesion	adhesion	NN	NN	_	2	compound	_	_
2	molecules	molecule	NNS	NNS	_	12	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	tether	tether	VBP	VBP	_	2	acl:relcl	_	_
5	circulating	circulate	VBG	VBG	_	6	amod	_	_
6	leukocytes	leukocyte	NNS	NNS	_	4	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	transduce	transduce	VB	VB	_	0	root	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	modulate	modulate	VB	VB	_	12	conj	_	_
15	outside-in	outside-in	JJ	JJ	_	16	amod	_	_
16	signals	signal	NNS	NNS	_	12	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	providing	provide	VBG	VBG	_	12	advcl	_	_
22	an	a	DT	DT	_	25	det	_	_
23	initial	initial	JJ	JJ	_	25	amod	_	_
24	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
25	point	point	NN	NN	_	21	dobj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	inflammatory	inflammatory	JJ	JJ	_	29	amod	_	_
29	response	response	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Adhesion	adhesion	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	P-selectin	p-selectin	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	14	det	_	_
9	most	most	RBS	RBS	_	10	advmod	_	_
10	rapidly	rapidly	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	14	amod	_	_
12	endothelial	endothelial	JJ	JJ	_	14	amod	_	_
13	tethering	tethering	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	6	appos	_	_
15	,	,	,	,	_	1	punct	_	_
16	increased	increase	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	secretion	secretion	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	monocyte	monocyte	NN	NN	_	22	compound	_	_
21	chemotactic	chemotactic	JJ	JJ	_	22	amod	_	_
22	protein-1	protein-1	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	MCP-1	mcp-1	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	tumor	tumor	NN	NN	_	29	compound	_	_
28	necrosis	necrosis	NN	NN	_	29	compound	_	_
29	factor-alpha	factor-alpha	NN	NN	_	22	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	TNF-alpha	tnf-alpha	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	by	by	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	leukocytes	leukocyte	NNS	NNS	_	18	nmod	_	_
36	when	when	WRB	WRB	_	39	advmod	_	_
37	they	they	PRP	PRP	_	39	nsubjpass	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	stimulated	stimulate	VBN	VBN	_	16	advcl	_	_
40	with	with	IN	IN	_	42	case	_	_
41	platelet-activating	platelet-activating	JJ	JJ	_	42	amod	_	_
42	factor	factor	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	16	punct	_	_

1	Increased	increase	VBN	VBN	_	3	amod	_	_
2	cytokine	cytokine	NN	NN	_	3	compound	_	_
3	secretion	secretion	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	specifically	specifically	RB	RB	_	6	advmod	_	_
6	inhibited	inhibit	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	G1	g1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	an	a	DT	DT	_	12	det	_	_
11	anti-P-selectin	anti-p-selectin	JJ	JJ	_	12	amod	_	_
12	mAb	mab	NN	NN	_	8	appos	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	prevents	prevent	VBZ	VBZ	_	12	acl:relcl	_	_
15	P-selectin	p-selectin	NN	NN	_	14	dobj	_	_
16	from	from	IN	IN	_	17	mark	_	_
17	binding	bind	VBG	VBG	_	14	advcl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	ligand	ligand	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	P-selectin	p-selectin	NN	NN	_	24	compound	_	_
23	glycoprotein	glycoprotein	NN	NN	_	24	compound	_	_
24	ligand-1	ligand-1	NN	NN	_	20	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	on	on	IN	IN	_	28	case	_	_
27	myeloid	myeloid	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	tethering	tethering	NN	NN	_	7	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	P-selectin	p-selectin	NN	NN	_	3	nmod	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	enhanced	enhance	VBD	VBD	_	0	root	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	translocation	translocation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	factor-kappa	factor-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	13	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	13	appos	_	_
22	required	require	VBN	VBN	_	21	acl	_	_
23	for	for	IN	IN	_	24	case	_	_
24	expression	expression	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	MCP-1	mcp-1	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	TNF-alpha	tnf-alpha	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	other	other	JJ	JJ	_	33	amod	_	_
32	immediate-early	immediate-early	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	26	conj	_	_
34	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	P-selectin	p-selectin	NN	NN	_	15	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	through	through	IN	IN	_	9	case	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	ligands	ligand	NNS	NNS	_	15	nmod	_	_
10	on	on	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	locally	locally	RB	RB	_	15	advmod	_	_
15	regulate	regulate	VB	VB	_	3	ccomp	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	secretion	secretion	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	inflamed	inflamed	JJ	JJ	_	20	amod	_	_
20	tissues	tissue	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Neutrophils	neutrophil	NNS	NNS	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	monocytes	monocyte	NNS	NNS	_	1	conj	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PU.1	pu.1	NN	NN	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Spi-1	spi-1	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	8	cc	_	_
14	Spi-B	spi-b	NN	NN	_	8	conj	_	_
15	.	.	.	.	_	4	punct	_	_

1	PU.1	pu.1	NN	NN	_	12	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Spi-1	spi-1	NN	NN	_	5	compound	_	_
5	oncogene	oncogene	NN	NN	_	1	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	1	cc	_	_
8	Spi-B	spi-b	NN	NN	_	1	conj	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	closely	closely	RB	RB	_	11	advmod	_	_
11	related	related	JJ	JJ	_	12	amod	_	_
12	members	member	NNS	NNS	_	0	root	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	ets	ets	NN	NN	_	18	compound	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	family	family	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	12	punct	_	_
20	sharing	share	VBG	VBG	_	12	advcl	_	_
21	similar	similar	JJ	JJ	_	24	amod	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	specificities	specificity	NNS	NNS	_	20	dobj	_	_
25	mediated	mediate	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	30	case	_	_
27	similar	similar	JJ	JJ	_	30	amod	_	_
28	DNA	dna	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	domains	domain	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	PU.1	pu.1	NN	NN	_	7	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Spi-B	spi-b	NN	NN	_	1	conj	_	_
4	have	have	VBP	VBP	_	7	aux	_	_
5	been	be	VBN	VBN	_	7	auxpass	_	_
6	previously	previously	RB	RB	_	7	advmod	_	_
7	described	describe	VBN	VBN	_	0	root	_	_
8	as	as	IN	IN	_	11	mark	_	_
9	being	be	VBG	VBG	_	11	auxpass	_	_
10	predominantly	predominantly	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	7	advcl	_	_
12	coordinately	coordinately	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	but	but	CC	CC	_	7	cc	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	expression	expression	NN	NN	_	44	nsubjpass	_	_
22	in	in	IN	IN	_	25	case	_	_
23	early	early	JJ	JJ	_	25	amod	_	_
24	hematopoietic	hematopoietic	JJ	JJ	_	25	amod	_	_
25	stages	stage	NNS	NNS	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	during	during	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	course	course	NN	NN	_	25	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	myeloid	myeloid	JJ	JJ	_	32	amod	_	_
32	differentiation	differentiation	NN	NN	_	29	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	macrophages	macrophage	NNS	NNS	_	34	conj	_	_
37	or	or	CC	CC	_	34	cc	_	_
38	to	to	TO	TO	_	39	case	_	_
39	neutrophils	neutrophil	NNS	NNS	_	34	conj	_	_
40	has	have	VBZ	VBZ	_	44	aux	_	_
41	not	not	RB	RB	_	44	neg	_	_
42	been	be	VBN	VBN	_	44	auxpass	_	_
43	extensively	extensively	RB	RB	_	44	advmod	_	_
44	investigated	investigate	VBN	VBN	_	7	conj	_	_
45	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	PU.1	pu.1	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	upregulated	upregulate	VBN	VBN	_	4	ccomp	_	_
10	during	during	IN	IN	_	12	case	_	_
11	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	purified	purify	VBN	VBN	_	17	amod	_	_
16	CD34+	cd34+	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	murine	murine	JJ	JJ	_	23	amod	_	_
20	multipotential	multipotential	JJ	JJ	_	23	amod	_	_
21	FDCP-mix	fdcp-mix	NN	NN	_	23	compound	_	_
22	A4	a4	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	conj	_	_
24	,	,	,	,	_	9	punct	_	_
25	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
26	that	that	IN	IN	_	29	mark	_	_
27	PU.1	pu.1	NN	NN	_	29	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	upregulated	upregulate	VBN	VBN	_	25	ccomp	_	_
30	as	as	IN	IN	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	early	early	JJ	JJ	_	33	amod	_	_
33	event	event	NN	NN	_	29	nmod	_	_
34	during	during	IN	IN	_	35	case	_	_
35	differentiation	differentiation	NN	NN	_	29	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	multipotential	multipotential	JJ	JJ	_	39	amod	_	_
38	progenitor	progenitor	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	PU.1	pu.1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	maintained	maintained	JJ	JJ	_	0	root	_	_
5	at	at	IN	IN	_	7	case	_	_
6	stable	stable	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	4	nmod	_	_
8	during	during	IN	IN	_	9	case	_	_
9	differentiation	differentiation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	9	nmod	_	_
14	U937	u937	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HL-60	hl-60	NN	NN	_	14	conj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	monocytic	monocytic	JJ	JJ	_	9	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	neutrophilic	neutrophilic	JJ	JJ	_	18	conj	_	_
21	cells	cell	NNS	NNS	_	18	dep	_	_
22	.	.	.	.	_	4	punct	_	_

1	PU.1	pu.1	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	highest	highest	JJS	JJS	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	mature	mature	JJ	JJ	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	neutrophils	neutrophil	NNS	NNS	_	10	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	PU.1	pu.1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Spi-B	spi-b	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	10	conj	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	only	only	RB	RB	_	14	advmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	some	some	DT	DT	_	19	dep	_	_
18	B-cell	b-cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	spleen	spleen	NN	NN	_	19	conj	_	_
22	but	but	CC	CC	_	14	cc	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	found	find	VBN	VBN	_	14	conj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	neutrophils	neutrophil	NNS	NNS	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	or	or	CC	CC	_	29	cc	_	_
34	macrophages	macrophage	NNS	NNS	_	29	conj	_	_
35	.	.	.	.	_	14	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	5	advmod	_	_
3	translated	translate	VBN	VBN	_	5	amod	_	_
4	Spi-B	spi-b	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	bind	bind	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	PU.1	pu.1	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
14	promoters	promoter	NNS	NNS	_	7	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	transactivate	transactivate	VB	VB	_	7	conj	_	_
17	these	these	DT	DT	_	18	det	_	_
18	promoters	promoter	NNS	NNS	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	nonmyeloid	nonmyeloid	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	33	advmod	_	_
2	,	,	,	,	_	33	punct	_	_
3	although	although	IN	IN	_	8	mark	_	_
4	PU.1	pu.1	NN	NN	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Spi-B	spi-b	NN	NN	_	4	conj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	bind	bind	VB	VB	_	33	dep	_	_
9	to	to	TO	TO	_	13	case	_	_
10	similar	similar	JJ	JJ	_	13	amod	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	control	control	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	have	have	VBP	VBP	_	8	conj	_	_
16	redundancy	redundancy	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transactivation	transactivation	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	16	nmod	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vitro	vitro	FW	FW	_	15	advmod	_	_
22	,	,	,	,	_	33	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	lack	lack	NN	NN	_	33	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	significant	significant	JJ	JJ	_	27	amod	_	_
27	levels	level	NNS	NNS	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	Spi-B	spi-b	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	myeloid	myeloid	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	24	nmod	_	_
33	makes	make	VBZ	VBZ	_	0	root	_	_
34	it	it	PRP	PRP	_	38	nsubj	_	_
35	unlikely	unlikely	JJ	JJ	_	38	dep	_	_
36	that	that	IN	IN	_	38	mark	_	_
37	Spi-B	spi-b	NN	NN	_	38	nsubj	_	_
38	plays	play	VBZ	VBZ	_	33	xcomp	_	_
39	a	a	DT	DT	_	41	det	_	_
40	significant	significant	JJ	JJ	_	41	amod	_	_
41	role	role	NN	NN	_	38	dobj	_	_
42	in	in	IN	IN	_	45	case	_	_
43	myeloid	myeloid	JJ	JJ	_	45	amod	_	_
44	lineage	lineage	NN	NN	_	45	compound	_	_
45	development	development	NN	NN	_	38	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	gene	gene	NN	NN	_	48	compound	_	_
48	expression	expression	NN	NN	_	45	conj	_	_
49	.	.	.	.	_	33	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	PU.1	pu.1	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	at	at	IN	IN	_	9	case	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	6	nmod	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	only	only	RB	RB	_	13	cc:preconj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	macrophages	macrophage	NNS	NNS	_	13	conj	_	_
16	but	but	CC	CC	_	13	cc	_	_
17	also	also	RB	RB	_	19	advmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	13	conj	_	_
20	,	,	,	,	_	6	punct	_	_
21	indicating	indicate	VBG	VBG	_	6	advcl	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	PU.1	pu.1	NN	NN	_	25	nsubj	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	activate	activate	VB	VB	_	21	ccomp	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	32	case	_	_
29	both	both	DT	DT	_	32	dep	_	_
30	major	major	JJ	JJ	_	32	amod	_	_
31	myeloid	myeloid	JJ	JJ	_	32	amod	_	_
32	lineages	lineage	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	use	use	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	lymphoblastic	lymphoblastic	JJ	JJ	_	8	amod	_	_
8	leukemia	leukemia	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	childhood	childhood	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Molecular	molecular	JJ	JJ	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	cellular	cellular	JJ	JJ	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	clinical	clinical	JJ	JJ	_	1	conj	_	_
7	considerations	consideration	NNS	NNS	_	1	dep	_	_
8	.	.	.	.	_	1	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	included	include	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	almost	almost	RB	RB	_	7	advmod	_	_
7	all	all	DT	DT	_	9	amod	_	_
8	treatment	treatment	NN	NN	_	9	compound	_	_
9	regimens	regimen	NNS	NNS	_	4	nmod	_	_
10	for	for	IN	IN	_	14	case	_	_
11	childhood	childhood	NN	NN	_	14	compound	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	lymphoblastic	lymphoblastic	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	9	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	decades	decade	NNS	NNS	_	4	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	optimal	optimal	JJ	JJ	_	4	amod	_	_
4	agents	agent	NNS	NNS	_	10	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	doses	dose	NNS	NNS	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and/or	and/or	CC	CC	_	4	cc	_	_
9	schedules	schedule	NNS	NNS	_	4	conj	_	_
10	have	have	VBP	VBP	_	0	root	_	_
11	yet	yet	RB	RB	_	10	advmod	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	defined	define	VBN	VBN	_	10	xcomp	_	_
15	despite	despite	IN	IN	_	18	case	_	_
16	extensive	extensive	JJ	JJ	_	18	amod	_	_
17	clinical	clinical	JJ	JJ	_	16	dep	_	_
18	application	application	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	New	new	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	17	nsubj	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	pharmacokinetics	pharmacokinetic	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	pharmacodynamics	pharmacodynamic	NNS	NNS	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	5	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	action	action	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nmod	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	suggested	suggest	VBN	VBN	_	0	root	_	_
18	alternative	alternative	JJ	JJ	_	19	amod	_	_
19	approaches	approach	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	ALL	all	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	prolonged	prolonged	JJ	JJ	_	11	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	i.e.	i.e.	FW	FW	_	4	advcl	_	_
7	28	28	CD	CD	_	8	nummod	_	_
8	day	day	NN	NN	_	4	nmod:tmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	dep	_	_
11	therapy	therapy	NN	NN	_	14	nsubj	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	unnecessary	unnecessary	JJ	JJ	_	2	ccomp	_	_
15	as	as	IN	IN	_	19	mark	_	_
16	exposure	exposure	NN	NN	_	19	nsubj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	16	nmod	_	_
19	induces	induce	VBZ	VBZ	_	14	advcl	_	_
20	down-regulation	down-regulation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	cop	_	_
4	superior	superior	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	prednisone	prednisone	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	conventional	conventional	JJ	JJ	_	9	amod	_	_
9	equi-effective	equi-effective	JJ	JJ	_	10	amod	_	_
10	doses	dose	NNS	NNS	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Blast	blast	NN	NN	_	2	compound	_	_
2	sensitivity	sensitivity	NN	NN	_	5	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
5	correlates	correlate	VBZ	VBZ	_	0	root	_	_
6	closely	closely	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	sensitivity	sensitivity	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	14	case	_	_
10	other	other	JJ	JJ	_	14	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	putatively	putatively	RB	RB	_	13	advmod	_	_
13	non-cross-resisting	non-cross-resisting	JJ	JJ	_	10	dep	_	_
14	agents	agent	NNS	NNS	_	8	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	with	with	IN	IN	_	17	case	_	_
17	outcome	outcome	NN	NN	_	8	conj	_	_
18	after	after	IN	IN	_	20	case	_	_
19	multi-agent	multi-agent	JJ	JJ	_	20	amod	_	_
20	therapy	therapy	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
23	overlapping	overlapping	JJ	JJ	_	24	amod	_	_
24	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	action	action	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	focusing	focus	VBG	VBG	_	24	conj	_	_
30	attention	attention	NN	NN	_	29	dobj	_	_
31	on	on	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	determinants	determinant	NNS	NNS	_	29	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	threshold	threshold	NN	NN	_	33	nmod	_	_
37	for	for	IN	IN	_	38	case	_	_
38	apoptosis	apoptosis	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	Increasing	increase	VBG	VBG	_	2	amod	_	_
2	success	success	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	treatment	treatment	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	childhood	childhood	NN	NN	_	10	compound	_	_
8	acute	acute	JJ	JJ	_	10	amod	_	_
9	lymphoblastic	lymphoblastic	JJ	JJ	_	10	amod	_	_
10	leukemia	leukemia	NN	NN	_	5	nmod	_	_
11	has	have	VBZ	VBZ	_	12	aux	_	_
12	led	lead	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	increasing	increase	VBG	VBG	_	15	amod	_	_
15	awareness	awareness	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	avascular	avascular	JJ	JJ	_	18	amod	_	_
18	necrosis	necrosis	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	bone	bone	NN	NN	_	18	nmod	_	_
21	as	as	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	potentially	potentially	RB	RB	_	24	advmod	_	_
24	disabling	disabling	JJ	JJ	_	25	amod	_	_
25	sequela	sequela	NN	NN	_	15	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	glucocorticoid	glucocorticoid	NN	NN	_	28	compound	_	_
28	therapy	therapy	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	especially	especially	RB	RB	_	32	advmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	adolescent	adolescent	JJ	JJ	_	25	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	young	young	JJ	JJ	_	35	amod	_	_
35	adult	adult	JJ	JJ	_	32	conj	_	_
36	patients	patient	NNS	NNS	_	32	dep	_	_
37	.	.	.	.	_	12	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NF-AT	nf-at	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	2	nmod	_	_
7	during	during	IN	IN	_	8	case	_	_
8	restimulation	restimulation	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	2	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	anergy	anergy	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	CD4+	cd4+	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	clones	clone	NNS	NNS	_	1	nmod	_	_
7	through	through	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	1	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TcR	tcr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	by	by	IN	IN	_	16	case	_	_
15	high	high	JJ	JJ	_	16	amod	_	_
16	doses	dose	NNS	NNS	_	1	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	specific	specific	JJ	JJ	_	19	amod	_	_
19	peptide	peptide	NN	NN	_	16	nmod	_	_
20	results	result	VBZ	VBZ	_	0	root	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	induction	induction	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	long-lived	long-lived	JJ	JJ	_	27	amod	_	_
27	state	state	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	nonresponsiveness	nonresponsiveness	NN	NN	_	27	nmod	_	_
30	that	that	WDT	WDT	_	33	nsubjpass	_	_
31	has	have	VBZ	VBZ	_	33	aux	_	_
32	been	be	VBN	VBN	_	33	auxpass	_	_
33	called	call	VBN	VBN	_	27	acl:relcl	_	_
34	anergy	anergy	NN	NN	_	33	xcomp	_	_
35	.	.	.	.	_	20	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	induction	induction	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	anergy	anergy	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	11	nsubj	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	phenotypically	phenotypically	RB	RB	_	11	advmod	_	_
11	similar	similar	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	cells	cell	NNS	NNS	_	11	nmod	_	_
14	responding	respond	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	immunogenic	immunogenic	JJ	JJ	_	18	amod	_	_
18	stimulus	stimulus	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	amount	amount	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TcR	tcr	NN	NN	_	2	nmod	_	_
5	at	at	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	surface	surface	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	downmodulated	downmodulate	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	whereas	whereas	IN	IN	_	19	mark	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	CD2	cd2	NN	NN	_	19	nsubjpass	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	CD25	cd25	NN	NN	_	14	conj	_	_
17	receptors	receptor	NNS	NNS	_	14	dep	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	increased	increase	VBN	VBN	_	10	advcl	_	_
20	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	restimulated	restimulate	VBN	VBN	_	9	advcl	_	_
3	,	,	,	,	_	9	punct	_	_
4	however	however	RB	RB	_	9	advmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	anergic	anergic	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	fail	fail	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	up-regulate	up-regulate	VB	VB	_	9	xcomp	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	in	in	IN	IN	_	19	case	_	_
19	consequence	consequence	NN	NN	_	9	conj	_	_
20	do	do	VBP	VBP	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	produce	produce	VB	VB	_	9	dep	_	_
23	IL-2	il-2	NN	NN	_	22	dobj	_	_
24	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	compared	compare	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	various	various	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	bind	bind	VB	VB	_	9	acl	_	_
16	to	to	TO	TO	_	19	case	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	appropriate	appropriate	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	15	nmod	_	_
20	on	on	IN	IN	_	21	case	_	_
21	DNA	dna	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Factors	factor	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	nuclei	nucleus	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	15	nsubj	_	_
11	were	be	VBD	VBD	_	15	cop	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	induction	induction	NN	NN	_	15	compound	_	_
15	phase	phase	NN	NN	_	9	acl:relcl	_	_
16	of	of	IN	IN	_	17	case	_	_
17	anergy	anergy	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	15	cc	_	_
19	were	be	VBD	VBD	_	20	aux	_	_
20	undergoing	undergo	VBG	VBG	_	15	conj	_	_
21	activation	activation	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	restimulated	restimulate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	consistent	consistent	JJ	JJ	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pattern	pattern	NN	NN	_	11	nmod	_	_
15	that	that	WDT	WDT	_	19	nsubjpass	_	_
16	has	have	VBZ	VBZ	_	19	aux	_	_
17	previously	previously	RB	RB	_	19	advmod	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	shown	show	VBN	VBN	_	14	acl:relcl	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	regulate	regulate	VB	VB	_	19	xcomp	_	_
22	T-cell-specific	t-cell-specific	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	IL-2	il-2	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	the	the	DT	DT	_	30	det	_	_
29	beta	beta	NN	NN	_	30	compound	_	_
30	chain	chain	NN	NN	_	23	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	TcR	tcr	NN	NN	_	34	compound	_	_
34	genes	gene	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	measured	measure	VBN	VBN	_	3	amod	_	_
3	binding	binding	NN	NN	_	10	nsubj	_	_
4	to	to	TO	TO	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	TCF-1	tcf-1	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	the	the	DT	DT	_	10	det	_	_
10	same	same	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	resting	rest	VBG	VBG	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	activated	activate	VBN	VBN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	anergized	anergize	VBN	VBN	_	15	conj	_	_
21	cells	cell	NNS	NNS	_	15	dep	_	_
22	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inducible	inducible	JJ	JJ	_	3	amod	_	_
3	factors	factor	NNS	NNS	_	16	nsubjpass	_	_
4	NK-kappa	nk-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	3	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	beta	beta	NN	NN	_	8	compound	_	_
8	E2	e2	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	CD28RC	cd28rc	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	AP-1	ap-1	NN	NN	_	5	conj	_	_
14	are	be	VBP	VBP	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	expressed	express	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	resting	rest	VBG	VBG	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	twofold	twofold	RB	RB	_	23	advmod	_	_
23	lower	lower	RBR	RBR	_	16	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	anergized	anergize	VBN	VBN	_	23	nmod	_	_
26	as	as	IN	IN	_	27	mark	_	_
27	compared	compare	VBN	VBN	_	23	advcl	_	_
28	with	with	IN	IN	_	30	case	_	_
29	activated	activate	VBN	VBN	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	anergic	anergic	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	0	root	_	_
8	approximately	approximately	RB	RB	_	9	advmod	_	_
9	eightfold	eightfold	RB	RB	_	10	nmod:npmod	_	_
10	lower	lower	JJR	JJR	_	11	amod	_	_
11	amounts	amount	NNS	NNS	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-AT	nf-at	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	member	member	NN	NN	_	13	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	class	class	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	inducible	inducible	JJ	JJ	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	regulates	regulate	VBZ	VBZ	_	16	acl:relcl	_	_
25	IL-2	il-2	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	transcription	transcription	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	7	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	retinoblastoma	retinoblastoma	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	6	nsubj	_	_
5	negatively	negatively	RB	RB	_	6	advmod	_	_
6	regulates	regulate	VBZ	VBZ	_	0	root	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	mediated	mediate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	cytomegalovirus	cytomegalovirus	NN	NN	_	15	compound	_	_
14	IE2	ie2	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IE2	ie2	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	cytomegalovirus	cytomegalovirus	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HCMV	hcmv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	one	one	CD	CD	_	0	root	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	few	few	JJ	JJ	_	18	amod	_	_
16	viral	viral	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	12	nmod	_	_
19	expressed	express	VBN	VBN	_	18	acl	_	_
20	immediately	immediately	RB	RB	_	19	advmod	_	_
21	upon	upon	IN	IN	_	22	case	_	_
22	infection	infection	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	host	host	NN	NN	_	26	compound	_	_
26	cell	cell	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	It	it	PRP	PRP	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	many	many	JJ	JJ	_	9	amod	_	_
9	viral	viral	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cellular	cellular	JJ	JJ	_	9	conj	_	_
12	promoters	promoter	NNS	NNS	_	9	dep	_	_
13	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	retinoblastoma	retinoblastoma	NN	NN	_	8	compound	_	_
6	susceptibility	susceptibility	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	product	product	NN	NN	_	13	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Rb	rb	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	dramatically	dramatically	RB	RB	_	13	advmod	_	_
13	suppressed	suppress	VBD	VBD	_	2	ccomp	_	_
14	this	this	DT	DT	_	16	det	_	_
15	IE2	ie2	NN	NN	_	16	compound	_	_
16	transactivation	transactivation	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	promoters	promoter	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	unlike	unlike	IN	IN	_	7	case	_	_
4	another	another	DT	DT	_	7	det	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	suppressor	suppressor	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	14	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	p53	p53	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	14	punct	_	_
11	Rb	rb	NN	NN	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	have	have	VB	VB	_	0	root	_	_
15	any	any	DT	DT	_	17	det	_	_
16	significant	significant	JJ	JJ	_	17	amod	_	_
17	effect	effect	NN	NN	_	14	dobj	_	_
18	on	on	IN	IN	_	20	case	_	_
19	basal	basal	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	14	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	suggesting	suggest	VBG	VBG	_	14	advcl	_	_
25	that	that	IN	IN	_	28	mark	_	_
26	Rb	rb	NN	NN	_	28	nsubj	_	_
27	specifically	specifically	RB	RB	_	28	advmod	_	_
28	interacts	interact	VBZ	VBZ	_	24	ccomp	_	_
29	with	with	IN	IN	_	30	case	_	_
30	IE2	ie2	NN	NN	_	28	nmod	_	_
31	rather	rather	RB	RB	_	30	cc	_	_
32	than	than	IN	IN	_	31	mwe	_	_
33	other	other	JJ	JJ	_	35	amod	_	_
34	cellular	cellular	JJ	JJ	_	35	amod	_	_
35	factors	factor	NNS	NNS	_	30	conj	_	_
36	involved	involve	VBN	VBN	_	35	acl	_	_
37	in	in	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	general	general	JJ	JJ	_	41	amod	_	_
40	transcription	transcription	NN	NN	_	41	compound	_	_
41	machinery	machinery	NN	NN	_	36	nmod	_	_
42	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	by	by	IN	IN	_	5	case	_	_
4	protein-affinity	protein-affinity	JJ	JJ	_	5	amod	_	_
5	chromatography	chromatography	NN	NN	_	2	nmod	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	Rb	rb	NN	NN	_	18	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	extracts	extract	NNS	NNS	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	produced	produce	VBN	VBN	_	10	conj	_	_
13	by	by	IN	IN	_	16	case	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	translation	translation	NN	NN	_	12	nmod	_	_
17	directly	directly	RB	RB	_	18	advmod	_	_
18	bound	bind	VBD	VBD	_	2	ccomp	_	_
19	to	to	TO	TO	_	20	case	_	_
20	IE2	ie2	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Rb	rb	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	regulate	regulate	VB	VB	_	3	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	life	life	NN	NN	_	10	compound	_	_
10	cycle	cycle	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HCMV	hcmv	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	endemic	endemic	JJ	JJ	_	12	acl:relcl	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	population	population	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	provide	provide	VB	VB	_	0	root	_	_
7	new	new	JJ	JJ	_	8	amod	_	_
8	insights	insight	NNS	NNS	_	6	dobj	_	_
9	into	into	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	slow	slow	JJ	JJ	_	12	amod	_	_
12	rate	rate	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	HCMV	hcmv	NN	NN	_	16	compound	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	possible	possible	JJ	JJ	_	22	amod	_	_
22	involvement	involvement	NN	NN	_	12	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	HCMV	hcmv	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	tumorigenesis	tumorigenesis	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
2	virus	virus	NN	NN	_	5	compound	_	_
3	replicative	replicative	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	0	root	_	_
6	during	during	IN	IN	_	9	case	_	_
7	de	de	FW	FW	_	9	amod	_	_
8	novo	novo	FW	FW	_	7	dep	_	_
9	infection	infection	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
13	:	:	:	:	_	5	punct	_	_
14	simultaneous	simultaneous	JJ	JJ	_	15	amod	_	_
15	early	early	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	5	dep	_	_
17	of	of	IN	IN	_	18	case	_	_
18	BZLF-1	bzlf-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	repressor	repressor	NN	NN	_	18	conj	_	_
22	RAZ	raz	NN	NN	_	21	dep	_	_
23	.	.	.	.	_	5	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	infect	infect	VB	VB	_	7	xcomp	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	others	other	NNS	NNS	_	1	conj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	EBV	ebv	NN	NN	_	10	nsubj	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	infect	infect	VB	VB	_	5	ccomp	_	_
11	a	a	DT	DT	_	12	det	_	_
12	subset	subset	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	thymocytes	thymocyte	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Infection	infection	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	thymocytes	thymocyte	NNS	NNS	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	accompanied	accompany	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	appearance	appearance	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	linear	linear	JJ	JJ	_	12	amod	_	_
11	EBV	ebv	NN	NN	_	12	compound	_	_
12	genome	genome	NN	NN	_	8	nmod	_	_
13	within	within	IN	IN	_	15	case	_	_
14	8	8	CD	CD	_	15	nummod	_	_
15	hr	hr	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	infection	infection	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Circularization	circularization	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	EBV	ebv	NN	NN	_	5	compound	_	_
5	genome	genome	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	in	in	IN	IN	_	4	case	_	_
4	contrast	contrast	NN	NN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	infection	infection	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	where	where	WRB	WRB	_	15	advmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	genome	genome	NN	NN	_	15	nsubj	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	circularize	circularize	VB	VB	_	10	acl:relcl	_	_
16	within	within	IN	IN	_	18	case	_	_
17	24	24	CD	CD	_	18	nummod	_	_
18	hr	hr	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	infection	infection	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	appearance	appearance	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	BamHI	bamhi	NN	NN	_	8	compound	_	_
6	ZLF-1	zlf-1	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	product	product	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	ZEBRA	zebra	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	2	punct	_	_
12	by	by	IN	IN	_	13	case	_	_
13	RT-PCR	rt-pcr	NN	NN	_	2	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	0	root	_	_
17	within	within	IN	IN	_	19	case	_	_
18	8	8	CD	CD	_	19	nummod	_	_
19	hr	hr	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	infection	infection	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	appearance	appearance	NN	NN	_	26	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	fusion	fusion	NN	NN	_	7	compound	_	_
7	transcript	transcript	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RAZ	raz	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	comprised	comprise	VBD	VBD	_	7	acl:relcl	_	_
14	regions	region	NNS	NNS	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	BZLF-1	bzlf-1	NN	NN	_	18	compound	_	_
18	locus	locus	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	adjacent	adjacent	JJ	JJ	_	23	amod	_	_
22	BRLF-1	brlf-1	NN	NN	_	23	compound	_	_
23	locus	locus	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	2	punct	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	detected	detect	VBN	VBN	_	0	root	_	_
27	by	by	IN	IN	_	28	case	_	_
28	RT-PCR	rt-pcr	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	26	punct	_	_

1	ZEBRA	zebra	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	infected	infected	JJ	JJ	_	8	amod	_	_
8	thymocytes	thymocyte	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	immunoprecipitation	immunoprecipitation	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	EBNA-1	ebna-1	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	14	nsubjpass	_	_
10	in	in	IN	IN	_	12	case	_	_
11	infected	infected	JJ	JJ	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	transcribed	transcribe	VBN	VBN	_	5	ccomp	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	Fp	fp	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	rather	rather	RB	RB	_	18	cc	_	_
21	than	than	IN	IN	_	20	mwe	_	_
22	from	from	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	Cp/Wp	cp/wp	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	18	conj	_	_
26	which	which	WDT	WDT	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	used	use	VBN	VBN	_	25	acl:relcl	_	_
29	in	in	IN	IN	_	33	case	_	_
30	latently	latently	RB	RB	_	33	advmod	_	_
31	infected	infected	JJ	JJ	_	33	amod	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Transcripts	transcript	NNS	NNS	_	13	nsubjpass	_	_
2	encoding	encode	VBG	VBG	_	1	acl	_	_
3	gp350/220	gp350/220	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	major	major	JJ	JJ	_	8	amod	_	_
7	coat	coat	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	3	appos	_	_
9	of	of	IN	IN	_	10	case	_	_
10	EBV	ebv	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	identified	identify	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	but	but	CC	CC	_	13	cc	_	_
16	we	we	PRP	PRP	_	19	nsubj	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	find	find	VB	VB	_	13	conj	_	_
20	any	any	DT	DT	_	21	det	_	_
21	evidence	evidence	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	transcription	transcription	NN	NN	_	21	nmod	_	_
24	from	from	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	LMP-2A	lmp-2a	NN	NN	_	23	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	EBER-1	eber-1	NN	NN	_	29	compound	_	_
29	loci	locus	NNS	NNS	_	26	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	infected	infected	JJ	JJ	_	32	amod	_	_
32	thymocytes	thymocyte	NNS	NNS	_	23	nmod	_	_
33	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	de	de	FW	FW	_	8	amod	_	_
6	novo	novo	FW	FW	_	5	dep	_	_
7	EBV	ebv	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	thymocytes	thymocyte	NNS	NNS	_	8	nmod	_	_
11	differs	differ	VBZ	VBZ	_	3	ccomp	_	_
12	from	from	IN	IN	_	13	case	_	_
13	infection	infection	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	main	main	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	4	nsubj	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	with	with	IN	IN	_	7	case	_	_
7	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	no	no	DT	DT	_	10	neg	_	_
10	evidence	evidence	NN	NN	_	13	nsubjpass	_	_
11	could	could	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	4	ccomp	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	virus	virus	NN	NN	_	18	nsubj	_	_
17	ever	ever	RB	RB	_	18	advmod	_	_
18	circularizes	circularize	VBZ	VBZ	_	4	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	Rather	rather	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	EBV	ebv	NN	NN	_	4	nsubj	_	_
4	remains	remain	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	linear	linear	JJ	JJ	_	8	amod	_	_
8	configuration	configuration	NN	NN	_	4	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	14	nmod	_	_
11	replicative	replicative	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	transcribed	transcribe	VBN	VBN	_	8	acl:relcl	_	_
15	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Sp1	sp1	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
7	B-independent	b-independent	JJ	JJ	_	9	amod	_	_
8	HIV	hiv	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	11	compound	_	_
10	domain	domain	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	1	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	stimulated	stimulate	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	okadaic	okadaic	JJ	JJ	_	18	amod	_	_
18	acid	acid	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	26	nmod	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	purely	purely	RB	RB	_	6	advmod	_	_
6	enhancer-dependent	enhancer-dependent	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
10	such	such	JJ	JJ	_	12	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	TNF	tnf	NN	NN	_	9	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	HIV	hiv	NN	NN	_	20	compound	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	LTR	ltr	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	observed	observe	VBD	VBD	_	0	root	_	_
27	that	that	IN	IN	_	33	mark	_	_
28	okadaic	okadaic	JJ	JJ	_	29	amod	_	_
29	acid	acid	NN	NN	_	33	nsubj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	OKA	oka	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	activates	activate	VBZ	VBZ	_	26	ccomp	_	_
34	HIV	hiv	NN	NN	_	35	compound	_	_
35	transcription	transcription	NN	NN	_	33	dobj	_	_
36	through	through	IN	IN	_	39	case	_	_
37	both	both	CC	CC	_	39	cc:preconj	_	_
38	the	the	DT	DT	_	39	det	_	_
39	enhancer	enhancer	NN	NN	_	33	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	responding	respond	VBG	VBG	_	39	conj	_	_
42	to	to	TO	TO	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	factor	factor	NN	NN	_	41	nmod	_	_
45	NF-kappa	nf-kappa	NN	NN	_	46	compound	_	_
46	B	b	NN	NN	_	44	dep	_	_
47	,	,	,	,	_	39	punct	_	_
48	and	and	CC	CC	_	39	cc	_	_
49	the	the	DT	DT	_	51	det	_	_
50	promoter	promoter	NN	NN	_	51	compound	_	_
51	domain	domain	NN	NN	_	39	conj	_	_
52	of	of	IN	IN	_	54	case	_	_
53	the	the	DT	DT	_	54	det	_	_
54	LTR	ltr	NN	NN	_	51	nmod	_	_
55	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inducibility	inducibility	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	HIV	hiv	NN	NN	_	8	compound	_	_
5	LTR-driven	ltr-driven	JJ	JJ	_	8	amod	_	_
6	luciferase	luciferase	NN	NN	_	8	compound	_	_
7	expression	expression	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	lymphoblastoid	lymphoblastoid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	stimulated	stimulate	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	OKA	oka	NN	NN	_	12	nmod	_	_
15	depended	depend	VBD	VBD	_	0	root	_	_
16	on	on	IN	IN	_	21	case	_	_
17	both	both	CC	CC	_	21	cc:preconj	_	_
18	functional	functional	JJ	JJ	_	21	amod	_	_
19	Sp1	sp1	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	ability	ability	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	TATA	tata	NN	NN	_	28	compound	_	_
28	box	box	NN	NN	_	24	nmod	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	bind	bind	VB	VB	_	24	acl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	protein	protein	NN	NN	_	30	dobj	_	_
33	TBP	tbp	NN	NN	_	32	dep	_	_
34	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	both	both	CC	CC	_	3	cc:preconj	_	_
3	transformed	transform	VBN	VBN	_	10	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	normal	normal	JJ	JJ	_	3	conj	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	dep	_	_
7	,	,	,	,	_	10	punct	_	_
8	OKA	oka	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
10	induced	induce	VBD	VBD	_	0	root	_	_
11	intense	intense	JJ	JJ	_	12	amod	_	_
12	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	constitutively	constitutively	RB	RB	_	16	advmod	_	_
16	expressed	express	VBN	VBN	_	18	amod	_	_
17	Sp1	sp1	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	nucleus	nucleus	NN	NN	_	12	nmod	_	_
22	,	,	,	,	_	10	punct	_	_
23	a	a	DT	DT	_	24	det	_	_
24	property	property	NN	NN	_	10	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	OKA	oka	NN	NN	_	24	nmod	_	_
27	not	not	RB	RB	_	24	neg	_	_
28	shared	share	VBN	VBN	_	24	acl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	TNF	tnf	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	phorbol	phorbol	NN	NN	_	33	compound	_	_
33	ester	ester	NN	NN	_	30	conj	_	_
34	,	,	,	,	_	30	punct	_	_
35	or	or	CC	CC	_	30	cc	_	_
36	PHA	pha	NN	NN	_	30	conj	_	_
37	and	and	CC	CC	_	30	cc	_	_
38	interleukin	interleukin	NN	NN	_	30	conj	_	_
39	2	2	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	10	punct	_	_

1	Responsiveness	responsiveness	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	LTR	ltr	NN	NN	_	4	compound	_	_
4	constructs	construct	NNS	NNS	_	1	nmod	_	_
5	deleted	delete	VBN	VBN	_	4	acl	_	_
6	of	of	IN	IN	_	9	case	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	5	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	HIV	hiv	NN	NN	_	12	compound	_	_
12	Tat	tat	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	1	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	increased	increase	VBN	VBN	_	0	root	_	_
16	upon	upon	IN	IN	_	17	case	_	_
17	OKA	oka	NN	NN	_	15	nmod	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	17	cc	_	_
20	TNF	tnf	NN	NN	_	17	conj	_	_
21	stimulation	stimulation	NN	NN	_	17	dep	_	_
22	.	.	.	.	_	15	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	SP1	sp1	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	20	nsubj	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	OKA	oka	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	selective	selective	JJ	JJ	_	13	amod	_	_
13	inhibitor	inhibitor	NN	NN	_	9	appos	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	serine-threonine	serine-threonine	JJ	JJ	_	17	amod	_	_
17	phosphatase	phosphatase	NN	NN	_	13	nmod	_	_
18	PP2A	pp2a	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	6	punct	_	_
20	facilitates	facilitate	VBZ	VBZ	_	3	ccomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	formation	formation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	complex	complex	NN	NN	_	22	nmod	_	_
27	involving	involve	VBG	VBG	_	26	acl	_	_
28	general	general	JJ	JJ	_	30	amod	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	27	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	HIV	hiv	NN	NN	_	33	compound	_	_
33	Tat	tat	NN	NN	_	30	appos	_	_
34	,	,	,	,	_	33	punct	_	_
35	and	and	CC	CC	_	33	cc	_	_
36	Sp1	sp1	NN	NN	_	37	compound	_	_
37	proteins	protein	NNS	NNS	_	33	conj	_	_
38	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	formation	formation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	complex	complex	NN	NN	_	2	nmod	_	_
6	would	would	MD	MD	_	7	aux	_	_
7	increase	increase	VB	VB	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	independently	independently	RB	RB	_	16	advmod	_	_
10	of	of	IN	IN	_	9	dep	_	_
11	an	a	DT	DT	_	16	det	_	_
12	in	in	NN	NN	_	13	dep	_	_
13	synergy	synergy	NN	NN	_	16	nmod	_	_
14	with	with	IN	IN	_	13	acl	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	7	advmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	the	the	DT	DT	_	21	det	_	_
19	low	low	JJ	JJ	_	20	amod	_	_
20	basal	basal	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	7	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	HIV	hiv	NN	NN	_	25	compound	_	_
25	LTR	ltr	NN	NN	_	21	nmod	_	_
26	observed	observe	VBN	VBN	_	21	acl	_	_
27	in	in	IN	IN	_	30	case	_	_
28	normal	normal	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	MHC	mhc	NN	NN	_	5	compound	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	0	root	_	_
7	directed	direct	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	carboxyl	carboxyl	NN	NN	_	11	compound	_	_
11	terminus	terminus	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CIITA	ciita	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	one	one	CD	CD	_	13	appos	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	defective	defective	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	26	case	_	_
21	type	type	NN	NN	_	26	compound	_	_
22	II	ii	CD	CD	_	26	nummod	_	_
23	MHC	mhc	NN	NN	_	26	compound	_	_
24	combined	combined	JJ	JJ	_	26	amod	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	deficiency	deficiency	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Type	type	NN	NN	_	5	compound	_	_
2	II	ii	CD	CD	_	5	nummod	_	_
3	major	major	JJ	JJ	_	5	amod	_	_
4	histocompatibility	histocompatibility	NN	NN	_	5	compound	_	_
5	complex	complex	NN	NN	_	8	compound	_	_
6	combined	combined	JJ	JJ	_	8	amod	_	_
7	immune	immune	JJ	JJ	_	8	amod	_	_
8	deficiency	deficiency	NN	NN	_	23	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	type	type	NN	NN	_	13	compound	_	_
11	II	ii	CD	CD	_	13	nummod	_	_
12	MHC	mhc	NN	NN	_	13	compound	_	_
13	CID	cid	NN	NN	_	8	dep	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	bare	bare	JJ	JJ	_	17	amod	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	syndrome	syndrome	NN	NN	_	13	conj	_	_
18	)	)	-RRB-	-RRB-	_	13	punct	_	_
19	is	be	VBZ	VBZ	_	23	cop	_	_
20	a	a	DT	DT	_	23	det	_	_
21	congenital	congenital	JJ	JJ	_	23	amod	_	_
22	immunodeficiency	immunodeficiency	NN	NN	_	23	compound	_	_
23	disease	disease	NN	NN	_	0	root	_	_
24	characterized	characterize	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	30	case	_	_
26	absent	absent	JJ	JJ	_	30	amod	_	_
27	MHC	mhc	NN	NN	_	28	compound	_	_
28	class	class	NN	NN	_	30	compound	_	_
29	II	ii	CD	CD	_	28	nummod	_	_
30	expression	expression	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	Four	four	CD	CD	_	4	nummod	_	_
2	distinct	distinct	JJ	JJ	_	4	amod	_	_
3	complementation	complementation	NN	NN	_	4	compound	_	_
4	groups	group	NNS	NNS	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	Recently	recently	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	defective	defective	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	15	nsubjpass	_	_
6	in	in	IN	IN	_	12	case	_	_
7	group	group	NN	NN	_	12	compound	_	_
8	II	ii	CD	CD	_	12	nummod	_	_
9	type	type	NN	NN	_	12	compound	_	_
10	II	ii	CD	CD	_	12	nummod	_	_
11	MHC	mhc	NN	NN	_	12	compound	_	_
12	CID	cid	NN	NN	_	5	nmod	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	isolated	isolate	VBN	VBN	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	termed	term	VBN	VBN	_	15	conj	_	_
18	CIITA	ciita	NN	NN	_	17	xcomp	_	_
19	.	.	.	.	_	15	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	CIITA	ciita	NN	NN	_	14	nsubj	_	_
7	is	be	VBZ	VBZ	_	14	cop	_	_
8	an	a	DT	DT	_	14	det	_	_
9	MHC	mhc	NN	NN	_	14	compound	_	_
10	class	class	NN	NN	_	14	compound	_	_
11	II	ii	CD	CD	_	14	nummod	_	_
12	gene-specific	gene-specific	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	activator	activator	NN	NN	_	4	ccomp	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	function	function	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	provided	provide	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
10	acidic	acidic	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	amino	amino	NN	NN	_	14	compound	_	_
14	acids	acid	NNS	NNS	_	11	appos	_	_
15	26-137	26-137	CD	CD	_	14	nummod	_	_
16	)	)	-RRB-	-RRB-	_	14	punct	_	_
17	,	,	,	,	_	11	punct	_	_
18	which	which	WDT	WDT	_	21	nsubj	_	_
19	is	be	VBZ	VBZ	_	21	cop	_	_
20	experimentally	experimentally	RB	RB	_	21	advmod	_	_
21	exchangeable	exchangeable	JJ	JJ	_	11	acl:relcl	_	_
22	with	with	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	heterologous	heterologous	JJ	JJ	_	27	amod	_	_
25	viral	viral	JJ	JJ	_	27	amod	_	_
26	transcription-activating	transcription-activating	JJ	JJ	_	27	amod	_	_
27	domain	domain	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	specificity	specificity	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CIITA	ciita	NN	NN	_	2	nmod	_	_
5	for	for	IN	IN	_	11	case	_	_
6	three	three	CD	CD	_	11	nummod	_	_
7	major	major	JJ	JJ	_	11	amod	_	_
8	MHC	mhc	NN	NN	_	11	compound	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	genes	gene	NNS	NNS	_	2	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	DR	dr	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	13	punct	_	_
15	DQ	dq	NN	NN	_	13	conj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	DP	dp	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	2	punct	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	mediated	mediate	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	25	case	_	_
22	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
23	remaining	remain	VBG	VBG	_	25	amod	_	_
24	C-terminal	c-terminal	JJ	JJ	_	25	amod	_	_
25	residues	residue	NNS	NNS	_	20	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	amino	amino	NN	NN	_	28	compound	_	_
28	acids	acid	NNS	NNS	_	25	appos	_	_
29	317-1130	317-1130	CD	CD	_	28	nummod	_	_
30	)	)	-RRB-	-RRB-	_	28	punct	_	_
31	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	transactivation	transactivation	NN	NN	_	26	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	multiple	multiple	JJ	JJ	_	6	amod	_	_
5	cis	cis	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	especially	especially	RB	RB	_	9	advmod	_	_
9	S	s	NN	NN	_	6	appos	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	X2	x2	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	DR	dr	NN	NN	_	18	compound	_	_
16	alpha	alpha	NN	NN	_	18	compound	_	_
17	proximal	proximal	JJ	JJ	_	18	amod	_	_
18	promoter	promoter	NN	NN	_	6	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	group	group	NN	NN	_	23	compound	_	_
21	II	ii	CD	CD	_	23	nummod	_	_
22	CID	cid	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	CIITA	ciita	NN	NN	_	26	nmod:npmod	_	_
26	dependent	dependent	JJ	JJ	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	CIITA	ciita	NN	NN	_	3	compound	_	_
3	overexpression	overexpression	NN	NN	_	9	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	normal	normal	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	did	do	VBD	VBD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	increase	increase	VB	VB	_	15	advcl	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	propose	propose	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	initiation	initiation	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	CIITA	ciita	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	serves	serve	VBZ	VBZ	_	15	ccomp	_	_
22	as	as	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	on-off	on-off	JJ	JJ	_	25	amod	_	_
25	switch	switch	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	while	while	IN	IN	_	35	mark	_	_
28	availability	availability	NN	NN	_	35	nsubj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	downstream	downstream	JJ	JJ	_	33	amod	_	_
31	interactor	interactor	NN	NN	_	33	compound	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	s	s	NNS	NNS	_	28	nmod	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	limits	limit	VBZ	VBZ	_	21	advcl	_	_
36	transcription	transcription	NN	NN	_	35	dobj	_	_
37	.	.	.	.	_	15	punct	_	_

1	CAG	cag	NN	NN	_	4	compound	_	_
2	repeat	repeat	NN	NN	_	4	compound	_	_
3	length	length	NN	NN	_	4	compound	_	_
4	variation	variation	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	sperm	sperm	NN	NN	_	4	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	patient	patient	NN	NN	_	6	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	Kennedy	kennedy	NN	NN	_	13	nmod:poss	_	_
12	's	's	POS	POS	_	13	case	_	_
13	disease	disease	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	6	det	_	_
3	modified	modify	VBN	VBN	_	6	amod	_	_
4	sperm	sperm	NN	NN	_	6	compound	_	_
5	typing	typing	NN	NN	_	6	compound	_	_
6	protocol	protocol	NN	NN	_	1	dobj	_	_
7	,	,	,	,	_	1	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	mutation	mutation	NN	NN	_	10	compound	_	_
10	frequency	frequency	NN	NN	_	23	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	CAG	cag	NN	NN	_	15	compound	_	_
14	repeat	repeat	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	10	nmod	_	_
16	at	at	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	androgen	androgen	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	locus	locus	NN	NN	_	10	nmod	_	_
21	has	have	VBZ	VBZ	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	measured	measure	VBN	VBN	_	1	parataxis	_	_
24	using	use	VBG	VBG	_	23	xcomp	_	_
25	a	a	DT	DT	_	28	det	_	_
26	rare	rare	JJ	JJ	_	28	amod	_	_
27	semen	semen	NN	NN	_	28	compound	_	_
28	sample	sample	NN	NN	_	24	dobj	_	_
29	from	from	IN	IN	_	31	case	_	_
30	an	a	DT	DT	_	31	det	_	_
31	individual	individual	NN	NN	_	28	nmod	_	_
32	with	with	IN	IN	_	37	case	_	_
33	spinal	spinal	JJ	JJ	_	37	amod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	bulbar	bulbar	JJ	JJ	_	33	conj	_	_
36	muscular	muscular	JJ	JJ	_	37	amod	_	_
37	atrophy	atrophy	NN	NN	_	31	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	SBMA	sbma	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	1	punct	_	_

1	Among	among	IN	IN	_	5	case	_	_
2	258	258	CD	CD	_	5	nummod	_	_
3	X	x	NN	NN	_	5	compound	_	_
4	chromosome-containing	chromosome-containing	JJ	JJ	_	5	amod	_	_
5	sperm	sperm	NN	NN	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	19	19	CD	CD	_	8	compound	_	_
8	%	%	NN	NN	_	9	nsubj	_	_
9	had	have	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	repeat	repeat	NN	NN	_	12	compound	_	_
12	number	number	NN	NN	_	9	dobj	_	_
13	equal	equal	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	donor	donor	NN	NN	_	19	nmod:poss	_	_
17	's	's	POS	POS	_	19	case	_	_
18	somatic	somatic	JJ	JJ	_	19	amod	_	_
19	DNA	dna	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	47	47	CD	CD	_	22	nummod	_	_
22	repeats	repeat	NNS	NNS	_	12	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	9	punct	_	_
25	66	66	CD	CD	_	26	compound	_	_
26	%	%	NN	NN	_	28	nsubj	_	_
27	were	be	VBD	VBD	_	28	cop	_	_
28	expansions	expansion	NNS	NNS	_	9	conj	_	_
29	and	and	CC	CC	_	9	cc	_	_
30	15	15	CD	CD	_	31	compound	_	_
31	%	%	NN	NN	_	33	nsubj	_	_
32	were	be	VBD	VBD	_	33	cop	_	_
33	contractions	contraction	NNS	NNS	_	9	conj	_	_
34	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	average	average	JJ	JJ	_	3	amod	_	_
3	expansion	expansion	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	2.7	2.7	CD	CD	_	6	nummod	_	_
6	repeats	repeat	NNS	NNS	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	More	more	JJR	JJR	_	3	advmod	_	_
2	than	than	IN	IN	_	1	mwe	_	_
3	half	half	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expansions	expansion	NNS	NNS	_	3	nmod	_	_
7	involved	involve	VBD	VBD	_	0	root	_	_
8	one	one	CD	CD	_	7	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	two	two	CD	CD	_	8	conj	_	_
11	repeats	repeat	NNS	NNS	_	8	dep	_	_
12	;	;	:	:	_	7	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	largest	largest	JJS	JJS	_	17	nsubj	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	11	11	CD	CD	_	17	nummod	_	_
17	repeats	repeat	NNS	NNS	_	7	parataxis	_	_
18	.	.	.	.	_	7	punct	_	_

1	68	68	CD	CD	_	2	nummod	_	_
2	%	%	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	contractions	contraction	NNS	NNS	_	2	nmod	_	_
6	were	be	VBD	VBD	_	8	cop	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	one	one	CD	CD	_	0	root	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	two	two	CD	CD	_	8	conj	_	_
11	repeats	repeat	NNS	NNS	_	8	dep	_	_
12	but	but	CC	CC	_	8	cc	_	_
13	six	six	CD	CD	_	20	nsubj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	16	16	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	were	be	VBD	VBD	_	20	cop	_	_
19	very	very	RB	RB	_	20	advmod	_	_
20	large	large	JJ	JJ	_	8	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	12-25	12-25	CD	CD	_	23	nummod	_	_
23	repeats	repeat	NNS	NNS	_	20	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	contraction	contraction	NN	NN	_	3	nsubj	_	_
3	generated	generate	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	allele	allele	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	intermediate	intermediate	JJ	JJ	_	10	amod	_	_
9	size	size	NN	NN	_	10	compound	_	_
10	range	range	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	33-39	33-39	CD	CD	_	13	nummod	_	_
13	repeats	repeat	NNS	NNS	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	3	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	alleles	allele	NNS	NNS	_	6	nsubjpass	_	_
3	have	have	VBP	VBP	_	6	aux	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	among	among	IN	IN	_	11	case	_	_
8	more	more	JJR	JJR	_	10	advmod	_	_
9	than	than	IN	IN	_	8	mwe	_	_
10	900	900	CD	CD	_	11	nummod	_	_
11	normal	normal	JJ	JJ	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	SBMA	sbma	NN	NN	_	14	compound	_	_
14	X-chromosomes	x-chromosome	NNS	NNS	_	11	conj	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	have	have	VBP	VBP	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	examined	examine	VBN	VBN	_	11	acl:relcl	_	_
19	.	.	.	.	_	6	punct	_	_

1	Comparison	comparison	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	SBMA	sbma	NN	NN	_	7	compound	_	_
5	sperm	sperm	NN	NN	_	7	compound	_	_
6	typing	typing	NN	NN	_	7	compound	_	_
7	results	result	NNS	NNS	_	1	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	mutation	mutation	NN	NN	_	11	compound	_	_
10	frequency	frequency	NN	NN	_	11	compound	_	_
11	data	datum	NNS	NNS	_	1	nmod	_	_
12	on	on	IN	IN	_	14	case	_	_
13	normal	normal	JJ	JJ	_	14	amod	_	_
14	alleles	allele	NNS	NNS	_	11	nmod	_	_
15	supports	support	VBZ	VBZ	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	hypothesis	hypothesis	NN	NN	_	15	dobj	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	trinucleotide	trinucleotide	NN	NN	_	20	compound	_	_
20	repeat	repeat	NN	NN	_	21	compound	_	_
21	expansions	expansion	NNS	NNS	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	have	have	VB	VB	_	17	ccomp	_	_
24	a	a	DT	DT	_	27	det	_	_
25	different	different	JJ	JJ	_	27	amod	_	_
26	molecular	molecular	JJ	JJ	_	27	amod	_	_
27	origin	origin	NN	NN	_	23	dobj	_	_
28	than	than	IN	IN	_	29	case	_	_
29	contractions	contraction	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	differentially	differentially	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	6	amod	_	_
5	sequence	sequence	NN	NN	_	6	compound	_	_
6	tags	tag	NNS	NNS	_	1	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	steroid-responsive	steroid-responsive	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	using	use	VBG	VBG	_	1	dep	_	_
11	mRNA	mrna	NN	NN	_	13	compound	_	_
12	differential	differential	JJ	JJ	_	13	amod	_	_
13	display	display	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	1	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	steroid-regulated	steroid-regulated	JJ	JJ	_	6	amod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	networks	network	NNS	NNS	_	2	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	2	nmod	_	_
11	results	result	VBZ	VBZ	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	coordinate	coordinate	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	limited	limited	JJ	JJ	_	19	amod	_	_
19	number	number	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	target	target	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	much	much	JJ	JJ	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	known	know	VBN	VBN	_	21	advcl	_	_
5	about	about	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	structure	structure	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	function	function	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	steroid	steroid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	21	punct	_	_
14	relatively	relatively	RB	RB	_	15	advmod	_	_
15	few	few	JJ	JJ	_	18	amod	_	_
16	cell-specific	cell-specific	JJ	JJ	_	18	amod	_	_
17	steroid-regulated	steroid-regulated	JJ	JJ	_	16	dep	_	_
18	genes	gene	NNS	NNS	_	21	nsubjpass	_	_
19	have	have	VBP	VBP	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	isolated	isolate	VBN	VBN	_	0	root	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	characterized	characterize	VBN	VBN	_	21	conj	_	_
24	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	describe	describe	VBP	VBP	_	0	root	_	_
6	results	result	NNS	NNS	_	5	dobj	_	_
7	using	use	VBG	VBG	_	6	acl	_	_
8	mRNA	mrna	NN	NN	_	7	dobj	_	_
9	differential	differential	JJ	JJ	_	13	amod	_	_
10	display	display	NN	NN	_	13	compound	_	_
11	reverse	reverse	JJ	JJ	_	12	amod	_	_
12	transcriptase	transcriptase	NN	NN	_	13	compound	_	_
13	PCR	pcr	NN	NN	_	8	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	DDPCR	ddpcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	identify	identify	VB	VB	_	5	advcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	isolate	isolate	VB	VB	_	18	conj	_	_
21	short	short	JJ	JJ	_	24	amod	_	_
22	cDNA	cdna	NN	NN	_	24	compound	_	_
23	sequence	sequence	NN	NN	_	24	compound	_	_
24	tags	tag	NNS	NNS	_	18	dobj	_	_
25	from	from	IN	IN	_	26	case	_	_
26	thymocyte	thymocyte	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	prostate	prostate	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	conj	_	_
30	under	under	IN	IN	_	33	case	_	_
31	various	various	JJ	JJ	_	33	amod	_	_
32	hormone	hormone	NN	NN	_	33	compound	_	_
33	conditions	condition	NNS	NNS	_	18	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	this	this	DT	DT	_	3	det	_	_
3	technique	technique	NN	NN	_	1	dobj	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	isolated	isolate	VBN	VBN	_	1	parataxis	_	_
7	several	several	JJ	JJ	_	11	amod	_	_
8	differentially	differentially	RB	RB	_	11	advmod	_	_
9	expressed	express	VBN	VBN	_	11	amod	_	_
10	sequence	sequence	NN	NN	_	11	compound	_	_
11	tags	tag	NNS	NNS	_	6	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	DESTs	dest	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	from	from	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	mouse	mouse	NN	NN	_	20	compound	_	_
18	thymocyte	thymocyte	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	6	nmod	_	_
21	WEHI	wehi	NN	NN	_	20	dep	_	_
22	7.2	7.2	CD	CD	_	21	nummod	_	_
23	.	.	.	.	_	1	punct	_	_

1	Two	two	CD	CD	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	DESTs	dest	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	GIG10	gig10	NN	NN	_	1	appos	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	GIG18	gig18	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	1	punct	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	within	within	IN	IN	_	17	case	_	_
16	2	2	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	treatment	treatment	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	GIG10	gig10	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	novel	novel	JJ	JJ	_	5	amod	_	_
5	sequence	sequence	NN	NN	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	GIG18	gig18	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	the	the	DT	DT	_	11	det	_	_
10	mouse	mouse	NN	NN	_	11	compound	_	_
11	homologue	homologue	NN	NN	_	5	conj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	expressed	express	VBN	VBN	_	17	amod	_	_
16	sequence	sequence	NN	NN	_	17	compound	_	_
17	tag	tag	NN	NN	_	11	nmod	_	_
18	isolated	isolate	VBN	VBN	_	17	acl	_	_
19	from	from	IN	IN	_	22	case	_	_
20	activated	activate	VBN	VBN	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	used	use	VBD	VBD	_	0	root	_	_
4	DDPCR	ddpcr	NN	NN	_	3	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	isolate	isolate	VB	VB	_	3	advcl	_	_
7	DESTs	dest	NNS	NNS	_	6	dobj	_	_
8	from	from	IN	IN	_	13	case	_	_
9	androgen-modulated	androgen-modulated	JJ	JJ	_	13	amod	_	_
10	rat	rat	NN	NN	_	13	compound	_	_
11	ventral	ventral	JJ	JJ	_	13	amod	_	_
12	prostate	prostate	NN	NN	_	13	compound	_	_
13	tissue	tissue	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	one	one	CD	CD	_	19	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	15	nmod	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	characterized	characterize	VBD	VBD	_	3	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	found	find	VBD	VBD	_	19	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	correspond	correspond	VB	VB	_	21	xcomp	_	_
24	to	to	TO	TO	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	3'	3'	JJ	JJ	_	27	amod	_	_
27	end	end	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	33	case	_	_
29	prostatic	prostatic	JJ	JJ	_	33	amod	_	_
30	spermine	spermine	NN	NN	_	33	compound	_	_
31	binding	binding	NN	NN	_	33	compound	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	27	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	a	a	DT	DT	_	38	det	_	_
36	known	known	JJ	JJ	_	38	amod	_	_
37	androgen-regulated	androgen-regulated	JJ	JJ	_	38	amod	_	_
38	gene	gene	NN	NN	_	33	appos	_	_
39	.	.	.	.	_	3	punct	_	_

1	Modifications	modification	NNS	NNS	_	22	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	original	original	JJ	JJ	_	6	amod	_	_
5	DDPCR	ddpcr	NN	NN	_	6	compound	_	_
6	protocol	protocol	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	which	which	WDT	WDT	_	10	dobj	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	found	find	VBD	VBD	_	6	acl:relcl	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	potentially	potentially	RB	RB	_	13	advmod	_	_
13	decrease	decrease	VB	VB	_	10	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	frequency	frequency	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	isolating	isolate	VBG	VBG	_	19	amod	_	_
18	false-positive	false-positive	JJ	JJ	_	19	amod	_	_
19	DESTs	dest	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	1	punct	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	described	describe	VBN	VBN	_	0	root	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	merits	merit	NNS	NNS	_	38	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	DDPCR	ddpcr	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	25	punct	_	_
29	relative	relative	JJ	JJ	_	38	dep	_	_
30	to	to	TO	TO	_	35	case	_	_
31	other	other	JJ	JJ	_	35	amod	_	_
32	differential	differential	JJ	JJ	_	35	amod	_	_
33	cDNA	cdna	NN	NN	_	35	compound	_	_
34	cloning	cloning	NN	NN	_	35	compound	_	_
35	strategies	strategy	NNS	NNS	_	29	nmod	_	_
36	,	,	,	,	_	38	punct	_	_
37	are	be	VBP	VBP	_	38	auxpass	_	_
38	discussed	discuss	VBN	VBN	_	22	conj	_	_
39	.	.	.	.	_	22	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	two	two	CD	CD	_	6	nummod	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	1	nmod	_	_
7	within	within	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	5'-untranslated	5'-untranslated	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	A	a	NN	NN	_	16	compound	_	_
15	gamma-globin	gamma-globin	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Interaction	interaction	NN	NN	_	25	nsubj	_	_
2	between	between	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	stage	stage	NN	NN	_	6	compound	_	_
5	selector	selector	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	SSE	sse	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	proximal	proximal	JJ	JJ	_	14	amod	_	_
13	gamma-globin	gamma-globin	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	hypersensitivity	hypersensitivity	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	6	conj	_	_
18	2	2	CD	CD	_	17	nummod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	locus	locus	NN	NN	_	23	compound	_	_
22	control	control	NN	NN	_	23	compound	_	_
23	region	region	NN	NN	_	17	nmod	_	_
24	partly	partly	RB	RB	_	25	advmod	_	_
25	mediates	mediate	VBZ	VBZ	_	0	root	_	_
26	the	the	DT	DT	_	28	det	_	_
27	competitive	competitive	JJ	JJ	_	28	amod	_	_
28	silencing	silencing	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	beta-globin	beta-globin	NN	NN	_	32	compound	_	_
32	promoter	promoter	NN	NN	_	28	nmod	_	_
33	in	in	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	fetal	fetal	JJ	JJ	_	37	amod	_	_
36	developmental	developmental	JJ	JJ	_	37	amod	_	_
37	stage	stage	NN	NN	_	25	nmod	_	_
38	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	18	mark	_	_
6	a	a	DT	DT	_	9	det	_	_
7	second	second	JJ	JJ	_	9	amod	_	_
8	SSE-like	sse-like	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	18	nsubj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	5'-untranslated	5'-untranslated	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	gamma-gene	gamma-gene	NN	NN	_	13	nmod	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	contributes	contribute	VBZ	VBZ	_	4	ccomp	_	_
19	to	to	TO	TO	_	22	case	_	_
20	this	this	DT	DT	_	22	det	_	_
21	competitive	competitive	JJ	JJ	_	22	amod	_	_
22	silencing	silencing	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	beta-gene	beta-gene	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Utilizing	utilize	VBG	VBG	_	0	root	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	1	dobj	_	_
5	in	in	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	fetal	fetal	JJ	JJ	_	10	amod	_	_
8	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	K562	k562	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	1	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	have	have	VBP	VBP	_	16	aux	_	_
16	shown	show	VBN	VBN	_	1	parataxis	_	_
17	that	that	IN	IN	_	27	mark	_	_
18	the	the	DT	DT	_	20	det	_	_
19	core	core	NN	NN	_	20	compound	_	_
20	enhancer	enhancer	NN	NN	_	27	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	hypersensitivity	hypersensitivity	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	20	nmod	_	_
24	2	2	CD	CD	_	23	nummod	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	preferentially	preferentially	RB	RB	_	27	advmod	_	_
27	interact	interact	VB	VB	_	16	ccomp	_	_
28	with	with	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	proximal	proximal	JJ	JJ	_	31	amod	_	_
31	gamma-promoter	gamma-promoter	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	absence	absence	NN	NN	_	27	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	SSE	sse	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	27	punct	_	_
39	completely	completely	RB	RB	_	40	advmod	_	_
40	silencing	silence	VBG	VBG	_	27	advcl	_	_
41	a	a	DT	DT	_	43	det	_	_
42	linked	link	VBN	VBN	_	43	amod	_	_
43	beta-promoter	beta-promoter	NN	NN	_	40	dobj	_	_
44	.	.	.	.	_	1	punct	_	_

1	Mutation	mutation	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	20-base	20-base	JJ	JJ	_	6	amod	_	_
5	pair	pair	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	gamma-gene	gamma-gene	NN	NN	_	11	compound	_	_
10	5'-untranslated	5'-untranslated	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	UTR	utr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	led	lead	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	derepression	derepression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	beta-promoter	beta-promoter	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	marked	marked	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	gamma-promoter	gamma-promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	mutation	mutation	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	repressor	repressor	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Fine	fine	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	3	nsubj	_	_
3	dissected	dissect	VBD	VBD	_	0	root	_	_
4	these	these	DT	DT	_	5	det	_	_
5	activities	activity	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	regions	region	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	5'-UTR	5'-utr	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	stage	stage	NN	NN	_	4	compound	_	_
3	selector	selector	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	localized	localize	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	region	region	NN	NN	_	6	nmod	_	_
10	centered	centered	JJ	JJ	_	9	amod	_	_
11	on	on	IN	IN	_	12	case	_	_
12	nucleotides	nucleotide	NNS	NNS	_	10	nmod	_	_
13	+13	+13	CD	CD	_	12	nummod	_	_
14	to	to	TO	TO	_	12	dep	_	_
15	+15	+15	CD	CD	_	12	nummod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Electromobility	electromobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	7	nsubj	_	_
4	utilizing	utilize	VBG	VBG	_	3	acl	_	_
5	this	this	DT	DT	_	6	det	_	_
6	sequence	sequence	NN	NN	_	4	dobj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	binding	binding	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	dep	_	_
11	fetal	fetal	JJ	JJ	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	erythroid-specific	erythroid-specific	JJ	JJ	_	11	conj	_	_
14	protein	protein	NN	NN	_	11	dep	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	repressor	repressor	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	5'-UTR	5'-utr	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	localized	localize	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	tandem	tandem	JJ	JJ	_	12	amod	_	_
11	GATA-like	gata-like	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	appear	appear	VBP	VBP	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	bind	bind	VB	VB	_	15	xcomp	_	_
18	a	a	DT	DT	_	19	det	_	_
19	complex	complex	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	two	two	CD	CD	_	22	nummod	_	_
22	proteins	protein	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	one	one	CD	CD	_	31	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	which	which	WDT	WDT	_	24	nmod	_	_
27	is	be	VBZ	VBZ	_	31	cop	_	_
28	the	the	DT	DT	_	31	det	_	_
29	erythroid	erythroid	JJ	JJ	_	31	amod	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	22	acl:relcl	_	_
32	GATA-1	gata-1	NN	NN	_	31	dep	_	_
33	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	5'-UTR	5'-utr	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	gamma-gene	gamma-gene	NN	NN	_	6	nmod	_	_
10	contains	contain	VBZ	VBZ	_	3	ccomp	_	_
11	sequences	sequence	NNS	NNS	_	10	dobj	_	_
12	that	that	WDT	WDT	_	15	nsubj	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	important	important	JJ	JJ	_	11	acl:relcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	transcriptional	transcriptional	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	developmental	developmental	JJ	JJ	_	18	conj	_	_
21	regulation	regulation	NN	NN	_	18	dep	_	_
22	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	Myc-associated	myc-associated	JJ	JJ	_	7	amod	_	_
3	zinc	zinc	NN	NN	_	7	compound	_	_
4	finger	finger	NN	NN	_	7	compound	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	one	one	CD	CD	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	four	four	CD	CD	_	14	nummod	_	_
12	important	important	JJ	JJ	_	14	amod	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	regions	region	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CD4	cd4	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CD4	cd4	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	important	important	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	developmental	developmental	JJ	JJ	_	11	amod	_	_
11	control	control	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	CD4	cd4	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	minimal	minimal	JJ	JJ	_	11	amod	_	_
10	CD4	cd4	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	nsubj	_	_
12	has	have	VBZ	VBZ	_	6	ccomp	_	_
13	four	four	CD	CD	_	16	nummod	_	_
14	factor	factor	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	12	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	each	each	DT	DT	_	22	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	required	require	VBN	VBN	_	16	acl:relcl	_	_
23	for	for	IN	IN	_	25	case	_	_
24	full	full	JJ	JJ	_	25	amod	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	biochemical	biochemical	JJ	JJ	_	1	dobj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mutagenesis	mutagenesis	NN	NN	_	2	conj	_	_
5	analyses	analysis	NNS	NNS	_	2	dep	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	determined	determine	VBD	VBD	_	1	parataxis	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	multiple	multiple	JJ	JJ	_	12	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	13	nsubj	_	_
13	bind	bind	VBP	VBP	_	8	ccomp	_	_
14	to	to	TO	TO	_	17	case	_	_
15	these	these	DT	DT	_	17	det	_	_
16	independent	independent	JJ	JJ	_	17	amod	_	_
17	sites	site	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	determined	determine	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	an	a	DT	DT	_	6	det	_	_
5	initiator-like	initiator-like	JJ	JJ	_	6	amod	_	_
6	sequence	sequence	NN	NN	_	18	nsubjpass	_	_
7	present	present	JJ	JJ	_	6	amod	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cap	cap	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	an	a	DT	DT	_	16	det	_	_
14	Ets	ets	NN	NN	_	16	compound	_	_
15	consensus	consensus	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	6	conj	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	2	ccomp	_	_
19	for	for	IN	IN	_	22	case	_	_
20	full	full	JJ	JJ	_	22	amod	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	function	function	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Myc-associated	myc-associated	JJ	JJ	_	9	amod	_	_
7	zinc	zinc	NN	NN	_	9	compound	_	_
8	finger	finger	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	13	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	MAZ	maz	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	appears	appear	VBZ	VBZ	_	3	ccomp	_	_
14	to	to	TO	TO	_	18	mark	_	_
15	be	be	VB	VB	_	18	cop	_	_
16	the	the	DT	DT	_	18	det	_	_
17	predominant	predominant	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	13	xcomp	_	_
19	binding	bind	VBG	VBG	_	18	acl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	one	one	CD	CD	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	sites	site	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	last	last	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	5	nsubj	_	_
4	closely	closely	RB	RB	_	5	advmod	_	_
5	resembles	resemble	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	ME1a1	me1a1	NN	NN	_	9	compound	_	_
8	G3AG4AG3	g3ag4ag3	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	5	xcomp	_	_
10	previously	previously	RB	RB	_	9	advmod	_	_
11	shown	show	VBN	VBN	_	9	acl	_	_
12	to	to	TO	TO	_	16	mark	_	_
13	be	be	VB	VB	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	critical	critical	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	11	xcomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	P2	p2	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	c-myc	c-myc	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	believe	believe	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	MAZ	maz	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	likely	likely	JJ	JJ	_	3	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	play	play	VB	VB	_	11	xcomp	_	_
14	an	a	DT	DT	_	16	det	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	role	role	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	control	control	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	developmental	developmental	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	CD4	cd4	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	Nm23H2	nm23h2	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	binds	bind	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	7	nmod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	activates	activate	VBZ	VBZ	_	7	conj	_	_
11	the	the	DT	DT	_	14	det	_	_
12	translocated	translocate	VBN	VBN	_	14	amod	_	_
13	c-myc	c-myc	NN	NN	_	14	compound	_	_
14	allele	allele	NN	NN	_	7	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	Burkitt	burkitt	NN	NN	_	18	nmod:poss	_	_
17	's	's	POS	POS	_	18	case	_	_
18	lymphoma	lymphoma	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	an	a	DT	DT	_	7	det	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	vivo	vivo	FW	FW	_	5	dep	_	_
7	footprint	footprint	NN	NN	_	3	dobj	_	_
8	over	over	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	PuF	puf	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	nmod	_	_
12	on	on	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	translocated	translocate	VBN	VBN	_	16	amod	_	_
15	c-myc	c-myc	NN	NN	_	16	compound	_	_
16	allele	allele	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	Burkitt	burkitt	NN	NN	_	21	nmod:poss	_	_
19	's	's	POS	POS	_	21	case	_	_
20	lymphoma	lymphoma	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PuF	puf	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	11	nsubj	_	_
4	on	on	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	silent	silent	JJ	JJ	_	9	amod	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	c-myc	c-myc	NN	NN	_	9	compound	_	_
9	allele	allele	NN	NN	_	3	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	unoccupied	unoccupied	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	by	by	IN	IN	_	7	case	_	_
4	electrophoretic	electrophoretic	JJ	JJ	_	7	amod	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	electrophoretic	electrophoretic	JJ	JJ	_	12	amod	_	_
10	mobility	mobility	NN	NN	_	12	compound	_	_
11	shift	shift	NN	NN	_	12	compound	_	_
12	assay	assay	NN	NN	_	7	conj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	antibody	antibody	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	UV	uv	NN	NN	_	17	compound	_	_
17	cross-linking	cross-linking	NN	NN	_	7	conj	_	_
18	followed	follow	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	SDS-gel	sds-gel	NN	NN	_	21	compound	_	_
21	electrophoresis	electrophoresis	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	7	punct	_	_
23	and	and	CC	CC	_	7	cc	_	_
24	Western	western	NN	NN	_	25	compound	_	_
25	analysis	analysis	NN	NN	_	7	conj	_	_
26	that	that	IN	IN	_	33	mark	_	_
27	Nm23H2	nm23h2	NN	NN	_	33	nsubj	_	_
28	in	in	IN	IN	_	32	case	_	_
29	B	b	NN	NN	_	32	compound	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	extracts	extract	NNS	NNS	_	27	nmod	_	_
33	bound	bind	VBD	VBD	_	2	ccomp	_	_
34	to	to	TO	TO	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	c-myc	c-myc	NN	NN	_	33	nmod	_	_
37	PuF	puf	NN	NN	_	38	compound	_	_
38	site	site	NN	NN	_	36	dep	_	_
39	.	.	.	.	_	2	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	13	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	c-myc	c-myc	NN	NN	_	6	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	DHL-9	dhl-9	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Raji	raji	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	PuF	puf	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	18	nsubj	_	_
18	functioned	function	VBD	VBD	_	13	ccomp	_	_
19	as	as	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	positive	positive	JJ	JJ	_	23	amod	_	_
22	regulatory	regulatory	JJ	JJ	_	23	amod	_	_
23	element	element	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	with	with	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	drop	drop	NN	NN	_	18	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	activity	activity	NN	NN	_	29	nmod	_	_
32	with	with	IN	IN	_	33	case	_	_
33	mutation	mutation	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	site	site	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	Access	access	NN	NN	_	6	nsubjpass	_	_
2	to	to	TO	TO	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	normal	normal	JJ	JJ	_	12	amod	_	_
10	silent	silent	JJ	JJ	_	12	amod	_	_
11	c-myc	c-myc	NN	NN	_	12	compound	_	_
12	allele	allele	NN	NN	_	6	nmod	_	_
13	;	;	:	:	_	6	punct	_	_
14	these	these	DT	DT	_	15	det	_	_
15	data	datum	NNS	NNS	_	16	nsubj	_	_
16	suggest	suggest	VBP	VBP	_	6	parataxis	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Nm23H2	nm23h2	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	involved	involve	VBN	VBN	_	16	ccomp	_	_
23	in	in	IN	IN	_	24	case	_	_
24	deregulation	deregulation	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	translocated	translocate	VBN	VBN	_	29	amod	_	_
28	c-myc	c-myc	NN	NN	_	29	compound	_	_
29	allele	allele	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	34	case	_	_
31	Burkitt	burkitt	NN	NN	_	34	nmod:poss	_	_
32	's	's	POS	POS	_	34	case	_	_
33	lymphoma	lymphoma	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	pp90rsk	pp90rsk	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	early	early	JJ	JJ	_	8	amod	_	_
6	growth	growth	NN	NN	_	8	compound	_	_
7	response-1	response-1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	1	conj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	pokeweed	pokeweed	NN	NN	_	12	compound	_	_
12	mitogen	mitogen	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	1	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	pokeweed	pokeweed	NN	NN	_	10	compound	_	_
10	mitogen	mitogen	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PWM	pwm	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	7	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	early	early	JJ	JJ	_	21	amod	_	_
19	growth	growth	NN	NN	_	21	compound	_	_
20	response-1	response-1	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	EGR-1	egr-1	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	in	in	IN	IN	_	29	case	_	_
26	normal	normal	JJ	JJ	_	29	amod	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	7	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	PWM	pwm	NN	NN	_	2	nsubj	_	_
2	regulates	regulate	VBZ	VBZ	_	0	root	_	_
3	EGR-1	egr-1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	by	by	IN	IN	_	8	case	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	transcriptional	transcriptional	JJ	JJ	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	post-transcriptional	post-transcriptional	JJ	JJ	_	8	conj	_	_
11	mechanisms	mechanism	NNS	NNS	_	8	dep	_	_
12	.	.	.	.	_	2	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	17	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	EGR-1	egr-1	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	fragments	fragment	NNS	NNS	_	3	nmod	_	_
8	linked	link	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	chloramphenicol	chloramphenicol	NN	NN	_	16	compound	_	_
12	acetyltransferase	acetyltransferase	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	CAT	cat	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	gene	gene	NN	NN	_	8	nmod	_	_
17	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	PWM	pwm	NN	NN	_	22	compound	_	_
20	induced	induced	JJ	JJ	_	22	amod	_	_
21	EGR-1	egr-1	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	conferred	confer	VBN	VBN	_	17	ccomp	_	_
25	by	by	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	CArG	carg	NN	NN	_	28	compound	_	_
28	motif	motif	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	C	c	NN	NN	_	31	compound	_	_
31	C-LSB-AT-RSB-6GG	c-lsb-at-rsb-6gg	NN	NN	_	28	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	EGR-1	egr-1	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	28	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	S6	s6	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	pp90rsk	pp90rsk	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	6	punct	_	_
14	evidenced	evidence	VBN	VBN	_	6	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	S6	s6	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	serum	serum	NN	NN	_	22	compound	_	_
21	response	response	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	SRF	srf	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	peptides	peptide	NNS	NNS	_	18	conj	_	_
27	,	,	,	,	_	16	punct	_	_
28	in	in	IN	IN	_	32	case	_	_
29	PWM	pwm	NN	NN	_	32	compound	_	_
30	treated	treated	JJ	JJ	_	32	amod	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	4	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	PWM	pwm	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	able	able	JJ	JJ	_	6	ccomp	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	initiate	initiate	VB	VB	_	10	xcomp	_	_
13	an	a	DT	DT	_	16	det	_	_
14	intracytoplasmic	intracytoplasmic	JJ	JJ	_	16	amod	_	_
15	signalling	signalling	NN	NN	_	16	compound	_	_
16	cascade	cascade	NN	NN	_	12	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	EGR-1	egr-1	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	16	conj	_	_
20	in	in	IN	IN	_	24	case	_	_
21	normal	normal	JJ	JJ	_	24	amod	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	12	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Infection	infection	NN	NN	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	Theileria	theileria	FW	FW	_	4	compound	_	_
4	annulata	annulata	FW	FW	_	1	nmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	matrix	matrix	NN	NN	_	9	compound	_	_
9	metalloproteinase	metalloproteinase	NN	NN	_	6	nmod	_	_
10	9	9	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	9	conj	_	_
14	AP-1	ap-1	NN	NN	_	13	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	bovine	bovine	JJ	JJ	_	17	amod	_	_
17	leucocytes	leucocyte	NNS	NNS	_	6	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Theileria	theileria	FW	FW	_	2	compound	_	_
2	annulata	annulata	FW	FW	_	3	nsubj	_	_
3	infects	infect	VBZ	VBZ	_	0	root	_	_
4	bovine	bovine	JJ	JJ	_	5	amod	_	_
5	leucocytes	leucocyte	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	results	result	VBZ	VBZ	_	3	conj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
10	reversible	reversible	JJ	JJ	_	11	amod	_	_
11	transformation	transformation	NN	NN	_	7	nmod	_	_
12	such	such	IN	IN	_	15	mark	_	_
13	that	that	IN	IN	_	15	mark	_	_
14	they	they	PRP	PRP	_	15	nsubj	_	_
15	become	become	VBP	VBP	_	3	advcl	_	_
16	immortalised	immortalise	VBN	VBN	_	15	xcomp	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	metastatic	metastatic	JJ	JJ	_	16	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	describes	describe	VBZ	VBZ	_	0	root	_	_
5	parasite-induced	parasite-induced	JJ	JJ	_	6	amod	_	_
6	changes	change	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	host	host	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	6	nmod	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	have	have	VBP	VBP	_	6	acl:relcl	_	_
14	a	a	DT	DT	_	16	det	_	_
15	direct	direct	JJ	JJ	_	16	amod	_	_
16	bearing	bearing	NN	NN	_	13	dobj	_	_
17	on	on	IN	IN	_	20	case	_	_
18	this	this	DT	DT	_	20	det	_	_
19	transformation	transformation	NN	NN	_	20	compound	_	_
20	process	process	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	T.	t.	FW	FW	_	3	compound	_	_
2	annulata-infected	annulata-infected	JJ	JJ	_	3	amod	_	_
3	leucocytes	leucocyte	NNS	NNS	_	4	nsubj	_	_
4	produce	produce	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	novel	novel	JJ	JJ	_	10	amod	_	_
9	metalloproteinase	metalloproteinase	NN	NN	_	10	compound	_	_
10	activities	activity	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	12	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	,	,	,	,	_	1	punct	_	_
5	previously	previously	RB	RB	_	6	advmod	_	_
6	called	call	VBN	VBN	_	1	acl	_	_
7	B1	b1	NN	NN	_	6	xcomp	_	_
8	,	,	,	,	_	1	punct	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	97-kDa	97-kda	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	0	root	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	secreted	secrete	VBN	VBN	_	12	acl:relcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	large	large	JJ	JJ	_	18	amod	_	_
18	amounts	amount	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	purified	purify	VBN	VBN	_	15	conj	_	_
23	from	from	IN	IN	_	27	case	_	_
24	protein-free	protein-free	JJ	JJ	_	27	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	conditioned	conditioned	JJ	JJ	_	24	dep	_	_
27	medium	medium	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	antiserum	antiserum	NN	NN	_	7	nsubjpass	_	_
3	to	to	TO	TO	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	enzyme	enzyme	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	isolate	isolate	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	cDNA	cdna	NN	NN	_	12	compound	_	_
12	clone	clone	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	predicted	predict	VBN	VBN	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	B1	b1	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	81	81	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	10	nmod:npmod	_	_
10	identical	identical	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	matrix	matrix	NN	NN	_	14	compound	_	_
14	metalloproteinase	metalloproteinase	NN	NN	_	10	nmod	_	_
15	9	9	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	MMP9	mmp9	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	10	punct	_	_
20	demonstrating	demonstrate	VBG	VBG	_	10	xcomp	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	it	it	PRP	PRP	_	26	nsubj	_	_
23	is	be	VBZ	VBZ	_	26	cop	_	_
24	the	the	DT	DT	_	26	det	_	_
25	bovine	bovine	JJ	JJ	_	26	amod	_	_
26	homologue	homologue	NN	NN	_	20	ccomp	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	enzyme	enzyme	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	RNAase	rnaase	NN	NN	_	3	compound	_	_
2	protection	protection	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	MMP9	mmp9	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	16	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	unique	unique	JJ	JJ	_	8	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	infected	infected	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	due	due	JJ	JJ	_	4	ccomp	_	_
17	to	to	TO	TO	_	21	case	_	_
18	increased	increase	VBN	VBN	_	21	amod	_	_
19	MMP9	mmp9	NN	NN	_	21	compound	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	assayed	assay	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	5	nmod	_	_
9	AP-1	ap-1	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	demonstrated	demonstrate	VBD	VBD	_	3	conj	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	it	it	PRP	PRP	_	16	nsubj	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	constitutively	constitutively	RB	RB	_	16	advmod	_	_
16	present	present	JJ	JJ	_	11	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	increased	increase	VBN	VBN	_	19	amod	_	_
19	amounts	amount	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	Theileria-infected	theileria-infected	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	4	nmod	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	assayed	assay	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	level	level	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	mRNA	mrna	NN	NN	_	6	nmod	_	_
9	encoding	encode	VBG	VBG	_	8	acl	_	_
10	c-Fos	c-fos	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	common	common	JJ	JJ	_	14	amod	_	_
14	component	component	NN	NN	_	10	appos	_	_
15	of	of	IN	IN	_	16	case	_	_
16	AP-1	ap-1	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	observed	observe	VBD	VBD	_	4	conj	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	it	it	PRP	PRP	_	23	nsubjpass	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	indeed	indeed	RB	RB	_	23	advmod	_	_
23	up-regulated	up-regulate	VBN	VBN	_	18	ccomp	_	_
24	in	in	IN	IN	_	26	case	_	_
25	infected	infected	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	AP-1	ap-1	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	implicated	implicate	VBN	VBN	_	25	advcl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	control	control	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	cycle	cycle	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	MMP9	mmp9	NN	NN	_	16	nsubj	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	confer	confer	VB	VB	_	4	conj	_	_
17	metastatic	metastatic	JJ	JJ	_	18	amod	_	_
18	properties	property	NNS	NNS	_	16	dobj	_	_
19	,	,	,	,	_	25	punct	_	_
20	these	these	DT	DT	_	21	det	_	_
21	results	result	NNS	NNS	_	25	nsubj	_	_
22	are	be	VBP	VBP	_	25	cop	_	_
23	of	of	IN	IN	_	25	case	_	_
24	considerable	considerable	JJ	JJ	_	25	amod	_	_
25	significance	significance	NN	NN	_	0	root	_	_
26	with	with	IN	IN	_	27	case	_	_
27	respect	respect	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	transformed	transform	VBN	VBN	_	31	amod	_	_
31	phenotype	phenotype	NN	NN	_	27	nmod	_	_
32	induced	induce	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	Theileria	theileria	FW	FW	_	35	compound	_	_
35	infection	infection	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	25	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	transcription	transcription	NN	NN	_	7	compound	_	_
4	factor	factor	NN	NN	_	7	compound	_	_
5	NF	nf	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
11	glutathione	glutathione	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	by	by	IN	IN	_	15	case	_	_
15	variations	variation	NNS	NNS	_	12	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	extracellular	extracellular	JJ	JJ	_	20	amod	_	_
19	cysteine	cysteine	NN	NN	_	20	compound	_	_
20	supply	supply	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	HIV-infected	hiv-infected	JJ	JJ	_	2	amod	_	_
2	individuals	individual	NNS	NNS	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	SIV-infected	siv-infected	JJ	JJ	_	6	amod	_	_
5	rhesus	rhesus	NN	NN	_	6	compound	_	_
6	macaques	macaque	NNS	NNS	_	2	conj	_	_
7	have	have	VBP	VBP	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	average	average	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	decreased	decrease	VBN	VBN	_	15	amod	_	_
14	plasma	plasma	NN	NN	_	15	compound	_	_
15	cysteine	cysteine	NN	NN	_	7	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cystine	cystine	NN	NN	_	15	conj	_	_
18	concentrations	concentration	NNS	NNS	_	15	dep	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	decreased	decrease	VBN	VBN	_	23	amod	_	_
21	intracellular	intracellular	JJ	JJ	_	23	amod	_	_
22	glutathione	glutathione	NN	NN	_	23	compound	_	_
23	levels	level	NNS	NNS	_	15	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	depletion	depletion	NN	NN	_	19	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	glutathione	glutathione	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	6	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Molt-4	molt-4	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	translocation	translocation	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	transcription	transcription	NN	NN	_	31	compound	_	_
28	factor	factor	NN	NN	_	31	compound	_	_
29	NF	nf	NN	NN	_	31	compound	_	_
30	kappa	kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	21	nmod	_	_
32	,	,	,	,	_	19	punct	_	_
33	whereas	whereas	IN	IN	_	41	mark	_	_
34	incubation	incubation	NN	NN	_	41	nsubj	_	_
35	with	with	IN	IN	_	38	case	_	_
36	increasing	increase	VBG	VBG	_	38	amod	_	_
37	extracellular	extracellular	JJ	JJ	_	38	amod	_	_
38	concentrations	concentration	NNS	NNS	_	34	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	cysteine	cysteine	NN	NN	_	38	nmod	_	_
41	inhibits	inhibit	VBZ	VBZ	_	19	advcl	_	_
42	the	the	DT	DT	_	43	dep	_	_
43	DNA-binding	dna-binding	JJ	JJ	_	41	dobj	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	transactivating	transactivating	JJ	JJ	_	43	conj	_	_
46	activity	activity	NN	NN	_	43	dep	_	_
47	of	of	IN	IN	_	50	case	_	_
48	NF	nf	NN	NN	_	50	compound	_	_
49	kappa	kappa	NN	NN	_	50	compound	_	_
50	B	b	NN	NN	_	43	nmod	_	_
51	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	inhibition	inhibition	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	31	advcl	_	_
8	with	with	IN	IN	_	13	case	_	_
9	increasing	increase	VBG	VBG	_	13	amod	_	_
10	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
11	glutathione	glutathione	NN	NN	_	13	compound	_	_
12	disulfide	disulfide	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	GSSG	gssg	NN	NN	_	18	nsubjpass	_	_
16	can	can	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	7	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	inhibit	inhibit	VB	VB	_	18	xcomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	directly	directly	RB	RB	_	20	advmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cell-free	cell-free	JJ	JJ	_	27	amod	_	_
27	systems	system	NNS	NNS	_	20	nmod	_	_
28	,	,	,	,	_	31	punct	_	_
29	our	we	PRP$	PRP$	_	30	nmod:poss	_	_
30	studies	study	NNS	NNS	_	31	nsubj	_	_
31	suggest	suggest	VBP	VBP	_	0	root	_	_
32	that	that	IN	IN	_	38	mark	_	_
33	GSSG	gssg	NN	NN	_	38	nsubj	_	_
34	is	be	VBZ	VBZ	_	38	cop	_	_
35	a	a	DT	DT	_	38	det	_	_
36	physiologically	physiologically	RB	RB	_	37	advmod	_	_
37	relevant	relevant	JJ	JJ	_	38	amod	_	_
38	inhibitor	inhibitor	NN	NN	_	31	ccomp	_	_
39	in	in	IN	IN	_	41	case	_	_
40	intact	intact	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	also	also	RB	RB	_	41	advmod	_	_
43	.	.	.	.	_	31	punct	_	_

1	NF	nf	NN	NN	_	3	compound	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	4	nsubj	_	_
4	controls	control	VBZ	VBZ	_	0	root	_	_
5	many	many	JJ	JJ	_	8	amod	_	_
6	immunologically	immunologically	RB	RB	_	8	advmod	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	4	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	so	so	RB	RB	_	13	advmod	_	_
11	our	we	PRP$	PRP$	_	12	nmod:poss	_	_
12	studies	study	NNS	NNS	_	13	nsubj	_	_
13	suggest	suggest	VBP	VBP	_	4	dep	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	system	system	NN	NN	_	20	nsubj	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	sensitive	sensitive	JJ	JJ	_	13	ccomp	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	only	only	RB	RB	_	28	cc:preconj	_	_
23	against	against	IN	IN	_	28	case	_	_
24	a	a	DT	DT	_	28	det	_	_
25	cysteine	cysteine	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	glutathione	glutathione	NN	NN	_	25	conj	_	_
28	deficiency	deficiency	NN	NN	_	20	nmod	_	_
29	but	but	CC	CC	_	28	cc	_	_
30	also	also	RB	RB	_	33	advmod	_	_
31	against	against	IN	IN	_	33	case	_	_
32	an	a	DT	DT	_	33	det	_	_
33	excess	excess	NN	NN	_	28	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	cysteine	cysteine	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Ah	ah	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	TCDD	tcdd	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	during	during	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	16	case	_	_
9	human	human	JJ	JJ	_	16	amod	_	_
10	Ah	ah	NN	NN	_	16	compound	_	_
11	receptor	receptor	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	TCDD	tcdd	NN	NN	_	16	compound	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	mRNA	mrna	NN	NN	_	7	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	4	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	individuals	individual	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	gene	gene	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	first	first	RB	RB	_	15	advmod	_	_
15	investigated	investigate	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	fractions	fraction	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	nucleated	nucleated	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	revealing	reveal	VBG	VBG	_	15	advcl	_	_
23	predominant	predominant	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	Ah	ah	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	monocyte	monocyte	NN	NN	_	33	compound	_	_
33	fraction	fraction	NN	NN	_	24	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	Then	then	RB	RB	_	14	advmod	_	_
2	the	the	DT	DT	_	4	det	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	14	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	AhR	ahr	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	various	various	JJ	JJ	_	12	amod	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	4	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	examined	examine	VBN	VBN	_	0	root	_	_
15	together	together	RB	RB	_	14	advmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	those	those	DT	DT	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Arnt	arnt	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	P450IA1	p450ia1	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	14	punct	_	_

1	AhR	ahr	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	monocytoid	monocytoid	JJ	JJ	_	9	amod	_	_
9	U937	u937	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	THP1	thp1	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	HEL/S	hel/s	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	conj	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	at	at	IN	IN	_	20	case	_	_
19	moderate	moderate	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	6	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	promyelocytic	promyelocytic	JJ	JJ	_	24	amod	_	_
23	HL60	hl60	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	6	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	erythroblastic	erythroblastic	JJ	JJ	_	28	amod	_	_
27	HEL	hel	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	lymphoid	lymphoid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	MOLT4	molt4	NN	NN	_	9	dep	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cell	cell	NN	NN	_	9	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	BALL1	ball1	NN	NN	_	9	conj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	9	punct	_	_
22	nor	nor	CC	CC	_	9	cc	_	_
23	in	in	IN	IN	_	25	case	_	_
24	K562	k562	NN	NN	_	25	compound	_	_
25	erythroblasts	erythroblast	NNS	NNS	_	9	conj	_	_
26	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	induction	induction	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	AhR	ahr	NN	NN	_	5	nmod	_	_
8	during	during	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	investigated	investigate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	HL60	hl60	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HEL	hel	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	12	punct	_	_

1	HL60	hl60	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	induced	induce	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	differentiate	differentiate	VB	VB	_	4	xcomp	_	_
7	toward	toward	IN	IN	_	8	case	_	_
8	monocytes-macrophages	monocytes-macrophage	NNS	NNS	_	6	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	incubation	incubation	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	ester	ester	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	showing	show	VBG	VBG	_	4	advcl	_	_
16	a	a	DT	DT	_	20	det	_	_
17	5-	5-	CD	CD	_	19	compound	_	_
18	to	to	TO	TO	_	19	dep	_	_
19	2-fold	2-fold	JJ	JJ	_	20	amod	_	_
20	increase	increase	NN	NN	_	15	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	AhR	ahr	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	incubation	incubation	NN	NN	_	13	nsubj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	transforming	transform	VBG	VBG	_	7	amod	_	_
5	growth	growth	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	beta	beta	NN	NN	_	2	nmod	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	1	1	CD	CD	_	12	nummod	_	_
11	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	12	compound	_	_
12	D3	d3	NN	NN	_	7	conj	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	5-	5-	CD	CD	_	18	compound	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	7-fold	7-fold	JJ	JJ	_	19	amod	_	_
19	increase	increase	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	AhR	ahr	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	HEL	hel	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	similar	similar	JJ	JJ	_	8	amod	_	_
8	elevation	elevation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	AhR	ahr	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	level	level	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	when	when	WRB	WRB	_	17	advmod	_	_
15	they	they	PRP	PRP	_	17	nsubj	_	_
16	had	have	VBD	VBD	_	17	aux	_	_
17	differentiated	differentiate	VBN	VBN	_	5	advcl	_	_
18	toward	toward	IN	IN	_	20	case	_	_
19	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	these	these	DT	DT	_	24	det	_	_
23	combined	combined	JJ	JJ	_	24	amod	_	_
24	inducers	inducer	NNS	NNS	_	17	nmod	_	_
25	,	,	,	,	_	5	punct	_	_
26	but	but	CC	CC	_	5	cc	_	_
27	little	little	JJ	JJ	_	28	amod	_	_
28	change	change	NN	NN	_	34	nsubjpass	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	mRNA	mrna	NN	NN	_	32	compound	_	_
32	level	level	NN	NN	_	28	nmod	_	_
33	was	be	VBD	VBD	_	34	auxpass	_	_
34	observed	observe	VBN	VBN	_	5	conj	_	_
35	when	when	WRB	WRB	_	39	advmod	_	_
36	the	the	DT	DT	_	37	det	_	_
37	cells	cell	NNS	NNS	_	39	nsubjpass	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	induced	induce	VBN	VBN	_	34	advcl	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	differentiate	differentiate	VB	VB	_	39	xcomp	_	_
42	into	into	IN	IN	_	45	case	_	_
43	other	other	JJ	JJ	_	45	amod	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	types	type	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	5	punct	_	_

1	Treatment	treatment	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	differentiated	differentiate	VBN	VBN	_	6	amod	_	_
5	HL60	hl60	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	3-methylcholanthrene	3-methylcholanthrene	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	ligand	ligand	NN	NN	_	8	appos	_	_
12	of	of	IN	IN	_	13	case	_	_
13	AhR	ahr	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	induced	induce	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	P450IA1	p450ia1	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	expression	expression	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	AhR	ahr	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	induced	induce	VBN	VBN	_	3	ccomp	_	_
12	during	during	IN	IN	_	14	case	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	differentiated	differentiate	VBN	VBN	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	21	nsubj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	responsive	responsive	JJ	JJ	_	11	conj	_	_
22	to	to	TO	TO	_	23	case	_	_
23	xenobiotics	xenobiotic	NNS	NNS	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	AhR	ahr	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	play	play	VB	VB	_	3	ccomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	function	function	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	also	also	RB	RB	_	21	advmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	eventual	eventual	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	13	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	environmental	environmental	JJ	JJ	_	24	amod	_	_
24	carcinogens	carcinogen	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Danazol	danazol	NN	NN	_	2	nsubj	_	_
2	decreases	decrease	VBZ	VBZ	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	estrogen	estrogen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	1.	1.	LS	LS	_	9	dep	_	_
2	Administration	administration	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	danazol	danazol	NN	NN	_	2	nmod	_	_
5	for	for	IN	IN	_	8	case	_	_
6	over	over	IN	IN	_	7	advmod	_	_
7	one	one	CD	CD	_	8	nummod	_	_
8	month	month	NN	NN	_	2	nmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	levels	level	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	estrogen	estrogen	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	ER	er	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	mRNA	mrna	NN	NN	_	14	conj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	approximately	approximately	RB	RB	_	23	advmod	_	_
23	50	50	CD	CD	_	9	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	20	20	CD	CD	_	23	conj	_	_
26	%	%	NN	NN	_	23	dep	_	_
27	,	,	,	,	_	9	punct	_	_
28	respectively	respectively	RB	RB	_	30	advmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	2.	2.	LS	LS	_	5	dep	_	_
2	Danazol	danazol	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	alter	alter	VB	VB	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	degradation	degradation	NN	NN	_	8	compound	_	_
8	rate	rate	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ER	er	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	3.	3.	LS	LS	_	3	dep	_	_
2	Danazol	danazol	NN	NN	_	3	nsubj	_	_
3	decreased	decrease	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	rate	rate	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	ER	er	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	approximately	approximately	RB	RB	_	12	advmod	_	_
12	50	50	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	3	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	run-on	run-on	JJ	JJ	_	19	amod	_	_
19	assay	assay	NN	NN	_	3	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	4.	4.	LS	LS	_	4	dep	_	_
2	Danazol	danazol	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	release	release	VB	VB	_	0	root	_	_
5	estrogen	estrogen	NN	NN	_	6	compound	_	_
6	predominance	predominance	NN	NN	_	4	dobj	_	_
7	via	via	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	reduction	reduction	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	transcription	transcription	NN	NN	_	9	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	ER	er	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	reduction	reduction	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	ER	er	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	ER	er	NN	NN	_	23	conj	_	_
26	expressions	expression	NNS	NNS	_	23	dep	_	_
27	in	in	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Physiological	physiological	JJ	JJ	_	2	amod	_	_
2	concentration	concentration	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	estradiol	estradiol	NN	NN	_	2	nmod	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	polymorphonuclear	polymorphonuclear	JJ	JJ	_	7	amod	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	chemotaxis	chemotaxis	NN	NN	_	5	dobj	_	_
9	via	via	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	mediated	mediated	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	5	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Estrogen	estrogen	NN	NN	_	2	nsubj	_	_
2	exhibits	exhibit	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	variety	variety	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	actions	action	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	including	include	VBG	VBG	_	10	case	_	_
9	immuno-modulatory	immuno-modulatory	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	14	advmod	_	_
14	and	and	CC	CC	_	10	advmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	14	advmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	13	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	estrogen	estrogen	NN	NN	_	6	nsubj	_	_
6	exerts	exert	VBZ	VBZ	_	2	acl:relcl	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	anti-inflammatory	anti-inflammatory	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	is	be	VBZ	VBZ	_	13	auxpass	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	yet	yet	RB	RB	_	13	advmod	_	_
13	understood	understand	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	possible	possible	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	estradiol	estradiol	NN	NN	_	5	nmod	_	_
8	acting	act	VBG	VBG	_	7	acl	_	_
9	via	via	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	polymorphonuclear	polymorphonuclear	JJ	JJ	_	12	amod	_	_
12	leukocytes	leukocyte	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PMNs	pmn	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	12	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	are	be	VBP	VBP	_	19	cop	_	_
19	important	important	JJ	JJ	_	12	acl:relcl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	agent	agent	NN	NN	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	17	17	CD	CD	_	5	nummod	_	_
5	beta-estradiol	beta-estradiol	NN	NN	_	2	appos	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	17	17	CD	CD	_	10	nummod	_	_
10	alpha-estradiol	alpha-estradiol	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	reduced	reduce	VBD	VBD	_	0	root	_	_
14	PMNs	pmn	NNS	NNS	_	15	compound	_	_
15	chemotaxis	chemotaxis	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	FMLP	fmlp	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	dose-dependent	dose-dependent	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	13	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	control	control	NN	NN	_	21	dep	_	_
24	vs	vs	CC	CC	_	23	cc	_	_
25	estrogen	estrogen	NN	NN	_	23	conj	_	_
26	10(-10)-(-6)	10(-10)-(-6)	CD	CD	_	27	nummod	_	_
27	M	m	NN	NN	_	25	dep	_	_
28	,	,	,	,	_	23	punct	_	_
29	P	p	NN	NN	_	23	appos	_	_
30	&lt;	&lt;	JJR	JJR	_	29	amod	_	_
31	0.05	0.05	CD	CD	_	30	dep	_	_
32	)	)	-RRB-	-RRB-	_	23	punct	_	_
33	.	.	.	.	_	13	punct	_	_

1	Physiological	physiological	JJ	JJ	_	2	amod	_	_
2	concentrations	concentration	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	estradiol	estradiol	NN	NN	_	2	nmod	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	reduced	reduce	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	chemotaxis	chemotaxis	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	PMNs	pmn	NNS	NNS	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	10(-10)	10(-10)	CD	CD	_	13	nummod	_	_
13	mol	mol	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	6	punct	_	_

1	Pre-incubation	pre-incubation	NN	NN	_	12	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	clomiphene	clomiphene	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	tamoxifen	tamoxifen	NN	NN	_	3	conj	_	_
6	which	which	WDT	WDT	_	10	nsubj	_	_
7	are	be	VBP	VBP	_	10	cop	_	_
8	estrogen	estrogen	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	antagonists	antagonist	NNS	NNS	_	3	acl:relcl	_	_
11	,	,	,	,	_	1	punct	_	_
12	eliminated	eliminate	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
15	effect	effect	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	17	17	CD	CD	_	18	nummod	_	_
18	beta-estradiol	beta-estradiol	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	chemotaxis	chemotaxis	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	PMNs	pmn	NNS	NNS	_	21	nmod	_	_
24	,	,	,	,	_	12	punct	_	_
25	restoring	restore	VBG	VBG	_	12	advcl	_	_
26	it	it	PRP	PRP	_	25	dobj	_	_
27	to	to	TO	TO	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	control	control	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	17	17	CD	CD	_	6	nummod	_	_
6	beta-estradiol	beta-estradiol	NN	NN	_	7	nsubj	_	_
7	suppressed	suppress	VBD	VBD	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	chemotaxis	chemotaxis	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PMNs	pmn	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	receptor-dependent	receptor-dependent	JJ	JJ	_	15	amod	_	_
15	mechanism	mechanism	NN	NN	_	7	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	level	level	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	estradiol	estradiol	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	plasma	plasma	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	15	nmod	_	_
13	PMNs	pmn	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	drawn	draw	VBN	VBN	_	10	acl:relcl	_	_
16	,	,	,	,	_	5	punct	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	22	det	_	_
19	close	close	JJ	JJ	_	22	amod	_	_
20	,	,	,	,	_	19	punct	_	_
21	inverse	inverse	JJ	JJ	_	19	dep	_	_
22	correlation	correlation	NN	NN	_	17	dobj	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	PMNs	pmn	NNS	NNS	_	26	compound	_	_
26	chemotaxis	chemotaxis	NN	NN	_	22	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	FMLP	fmlp	NN	NN	_	26	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	r	r	NN	NN	_	22	dep	_	_
31	=	=	JJ	JJ	_	30	amod	_	_
32	-0.821	-0.821	CD	CD	_	31	dep	_	_
33	p	p	NN	NN	_	30	dep	_	_
34	&lt;	&lt;	JJR	JJR	_	33	amod	_	_
35	0.001	0.001	CD	CD	_	34	dep	_	_
36	)	)	-RRB-	-RRB-	_	30	punct	_	_
37	.	.	.	.	_	17	punct	_	_

1	Estrogen	estrogen	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	modify	modify	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	neutrophils	neutrophil	NNS	NNS	_	5	nmod	_	_
8	during	during	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	normal	normal	JJ	JJ	_	12	amod	_	_
11	menstrual	menstrual	JJ	JJ	_	12	amod	_	_
12	cycle	cycle	NN	NN	_	3	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	only	only	RB	RB	_	12	dep	_	_
16	during	during	IN	IN	_	17	case	_	_
17	pregnancy	pregnancy	NN	NN	_	12	conj	_	_
18	,	,	,	,	_	3	punct	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	influence	influence	NN	NN	_	3	conj	_	_
21	inflammation	inflammation	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Heterogeneous	heterogeneous	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
5	virus	virus	NN	NN	_	7	compound	_	_
6	latent	latent	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	endemic	endemic	JJ	JJ	_	12	amod	_	_
10	Burkitt	burkitt	NN	NN	_	12	nmod:poss	_	_
11	's	's	POS	POS	_	12	case	_	_
12	lymphoma	lymphoma	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
2	virus	virus	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	EBV	ebv	NN	NN	_	7	compound	_	_
5	)	)	-RRB-	-RRB-	_	7	punct	_	_
6	-infected	-infected	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	sustain	sustain	VB	VB	_	0	root	_	_
10	three	three	CD	CD	_	12	nummod	_	_
11	distinct	distinct	JJ	JJ	_	12	amod	_	_
12	forms	form	NNS	NNS	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	latency	latency	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	lymphoblastoid	lymphoblastoid	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	44	nmod	_	_
5	,	,	,	,	_	44	punct	_	_
6	six	six	CD	CD	_	9	nummod	_	_
7	EBV-encoded	ebv-encoded	JJ	JJ	_	9	amod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	antigens	antigen	NNS	NNS	_	44	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	EBNA1	ebna1	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	2	2	CD	CD	_	11	amod	_	_
14	,	,	,	,	_	11	punct	_	_
15	3A	3a	NN	NN	_	11	appos	_	_
16	,	,	,	,	_	11	punct	_	_
17	3B	3b	NN	NN	_	11	appos	_	_
18	,	,	,	,	_	11	punct	_	_
19	3C	3c	NN	NN	_	11	appos	_	_
20	,	,	,	,	_	11	punct	_	_
21	-LP	-lp	NN	NN	_	11	appos	_	_
22	)	)	-RRB-	-RRB-	_	11	punct	_	_
23	,	,	,	,	_	9	punct	_	_
24	three	three	CD	CD	_	27	nummod	_	_
25	latent	latent	JJ	JJ	_	27	amod	_	_
26	membrane	membrane	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	9	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	LMP1	lmp1	NN	NN	_	27	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	2A	2a	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	29	punct	_	_
33	2B	2b	NN	NN	_	29	appos	_	_
34	)	)	-RRB-	-RRB-	_	29	punct	_	_
35	,	,	,	,	_	9	punct	_	_
36	and	and	CC	CC	_	9	cc	_	_
37	two	two	CD	CD	_	39	nummod	_	_
38	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
39	RNAs	rna	NNS	NNS	_	9	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	EBERs	eber	NNS	NNS	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	are	be	VBP	VBP	_	44	auxpass	_	_
44	expressed	express	VBN	VBN	_	0	root	_	_
45	.	.	.	.	_	44	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	form	form	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	latency	latency	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	termed	term	VBN	VBN	_	2	acl	_	_
7	latency	latency	NN	NN	_	6	xcomp	_	_
8	III	iii	CD	CD	_	7	nummod	_	_
9	,	,	,	,	_	2	punct	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	encountered	encounter	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	some	some	DT	DT	_	17	det	_	_
15	posttransplant	posttransplant	JJ	JJ	_	17	amod	_	_
16	lymphoproliferative	lymphoproliferative	JJ	JJ	_	17	amod	_	_
17	disorders	disorder	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	EBV-positive	ebv-positive	JJ	JJ	_	3	amod	_	_
3	cases	case	NNS	NNS	_	18	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Hodgkin	hodgkin	NN	NN	_	7	nmod:poss	_	_
6	's	's	POS	POS	_	7	case	_	_
7	disease	disease	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	18	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	EBERs	eber	NNS	NNS	_	18	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	EBNA1	ebna1	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	LMPs	lmp	NNS	NNS	_	10	conj	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	expressed	express	VBN	VBN	_	0	root	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	latency	latency	NN	NN	_	18	dep	_	_
21	II	ii	CD	CD	_	20	nummod	_	_
22	)	)	-RRB-	-RRB-	_	20	punct	_	_
23	,	,	,	,	_	18	punct	_	_
24	whereas	whereas	IN	IN	_	39	mark	_	_
25	in	in	IN	IN	_	28	case	_	_
26	Burkitt	burkitt	NN	NN	_	28	nmod:poss	_	_
27	's	's	POS	POS	_	26	case	_	_
28	lymphoma	lymphoma	NN	NN	_	39	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	BL	bl	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	only	only	RB	RB	_	34	advmod	_	_
33	the	the	DT	DT	_	34	det	_	_
34	EBERs	eber	NNS	NNS	_	39	nsubjpass	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	EBNA1	ebna1	NN	NN	_	34	conj	_	_
37	have	have	VBP	VBP	_	39	aux	_	_
38	been	be	VBN	VBN	_	39	auxpass	_	_
39	detected	detect	VBN	VBN	_	18	advcl	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	latency	latency	NN	NN	_	42	compound	_	_
42	I	i	NN	NN	_	39	dep	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	EBV	ebv	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	17	17	CD	CD	_	11	nummod	_	_
11	cases	case	NNS	NNS	_	3	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	EBV-positive	ebv-positive	JJ	JJ	_	11	acl	_	_
14	endemic	endemic	JJ	JJ	_	13	dep	_	_
15	BL	bl	NN	NN	_	13	dep	_	_
16	by	by	IN	IN	_	17	case	_	_
17	immunohistology	immunohistology	NN	NN	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	LMP1	lmp1	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	seen	see	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	variable	variable	JJ	JJ	_	8	amod	_	_
8	proportions	proportion	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	tumor	tumor	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	cases	case	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	EBNA2	ebna2	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	detected	detect	VBN	VBN	_	5	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	some	some	DT	DT	_	22	det	_	_
21	tumor	tumor	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	three	three	CD	CD	_	26	nummod	_	_
25	other	other	JJ	JJ	_	26	amod	_	_
26	cases	case	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Also	also	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	BZLF1	bzlf1	NN	NN	_	6	compound	_	_
5	trans-activator	trans-activator	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	few	few	JJ	JJ	_	13	amod	_	_
12	tumor	tumor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	6	6	CD	CD	_	16	nummod	_	_
16	cases	case	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	indicating	indicate	VBG	VBG	_	8	advcl	_	_
19	entry	entry	NN	NN	_	18	dobj	_	_
20	into	into	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	lytic	lytic	JJ	JJ	_	23	amod	_	_
23	cycle	cycle	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	phenotypic	phenotypic	JJ	JJ	_	3	amod	_	_
3	drift	drift	NN	NN	_	12	nsubjpass	_	_
4	from	from	IN	IN	_	6	case	_	_
5	latency	latency	NN	NN	_	6	compound	_	_
6	I	i	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	latency	latency	NN	NN	_	3	nmod	_	_
9	III	iii	CD	CD	_	8	nummod	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	previously	previously	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	some	some	DT	DT	_	18	det	_	_
16	BL	bl	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	similar	similar	JJ	JJ	_	7	amod	_	_
7	phenomenon	phenomenon	NN	NN	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	occur	occur	VB	VB	_	3	ccomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	BL	bl	NN	NN	_	9	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	9	advmod	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	indicate	indicate	VBP	VBP	_	3	conj	_	_
16	that	that	IN	IN	_	26	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	operational	operational	JJ	JJ	_	19	amod	_	_
19	definition	definition	NN	NN	_	26	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	EBV	ebv	NN	NN	_	22	compound	_	_
22	latencies	latency	NNS	NNS	_	19	nmod	_	_
23	is	be	VBZ	VBZ	_	26	auxpass	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	easily	easily	RB	RB	_	26	advmod	_	_
26	applied	apply	VBN	VBN	_	15	ccomp	_	_
27	to	to	TO	TO	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	tumors	tumor	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	peri-kappa	peri-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	5	nsubj	_	_
5	mediates	mediate	VBZ	VBZ	_	0	root	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
8	virus	virus	NN	NN	_	11	compound	_	_
9	type	type	NN	NN	_	11	compound	_	_
10	2	2	CD	CD	_	11	nummod	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	5	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	19	neg	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	13	nsubj	_	_
5	2	2	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HIV-2	hiv-2	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	4	punct	_	_
10	like	like	IN	IN	_	11	case	_	_
11	HIV-1	hiv-1	NN	NN	_	13	nmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	causes	cause	VBZ	VBZ	_	0	root	_	_
14	AIDS	aids	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	associated	associate	VBN	VBN	_	13	conj	_	_
18	with	with	IN	IN	_	20	case	_	_
19	AIDS	aids	NN	NN	_	20	compound	_	_
20	cases	case	NNS	NNS	_	17	nmod	_	_
21	primarily	primarily	RB	RB	_	20	advmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	West	West	NNP	NNP	_	24	compound	_	_
24	Africa	Africa	NNP	NNP	_	20	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	HIV-2	hiv-2	NN	NN	_	1	conj	_	_
4	display	display	VBP	VBP	_	0	root	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	differences	difference	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	nucleic	nucleic	JJ	JJ	_	10	amod	_	_
9	acid	acid	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	natural	natural	JJ	JJ	_	15	amod	_	_
15	history	history	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	clinical	clinical	JJ	JJ	_	18	amod	_	_
18	disease	disease	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Consistent	consistent	JJ	JJ	_	9	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	differences	difference	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	we	we	PRP	PRP	_	9	nsubj	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	previously	previously	RB	RB	_	9	advmod	_	_
9	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	enhancer/promoter	enhancer/promoter	NN	NN	_	13	compound	_	_
13	region	region	NN	NN	_	16	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	HIV-2	hiv-2	NN	NN	_	13	nmod	_	_
16	functions	function	VBZ	VBZ	_	9	ccomp	_	_
17	quite	quite	RB	RB	_	18	advmod	_	_
18	differently	differently	RB	RB	_	16	advmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	that	that	DT	DT	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	HIV-1	hiv-1	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Whereas	whereas	IN	IN	_	11	mark	_	_
2	activation	activation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	enhancer	enhancer	NN	NN	_	2	nmod	_	_
7	following	follow	VBG	VBG	_	9	case	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	45	advcl	_	_
12	largely	largely	RB	RB	_	11	advmod	_	_
13	through	through	IN	IN	_	14	case	_	_
14	binding	binding	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	14	nmod	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	18	dep	_	_
21	to	to	TO	TO	_	26	case	_	_
22	two	two	CD	CD	_	26	nummod	_	_
23	adjacent	adjacent	JJ	JJ	_	26	amod	_	_
24	kappa	kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	14	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	HIV-1	hiv-1	NN	NN	_	32	compound	_	_
30	long	long	JJ	JJ	_	32	amod	_	_
31	terminal	terminal	JJ	JJ	_	32	amod	_	_
32	repeat	repeat	NN	NN	_	26	nmod	_	_
33	,	,	,	,	_	45	punct	_	_
34	activation	activation	NN	NN	_	45	nsubj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	HIV-2	hiv-2	NN	NN	_	38	compound	_	_
38	enhancer	enhancer	NN	NN	_	34	nmod	_	_
39	in	in	IN	IN	_	40	case	_	_
40	monocytes	monocyte	NNS	NNS	_	34	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	40	conj	_	_
44	is	be	VBZ	VBZ	_	45	cop	_	_
45	dependent	dependent	JJ	JJ	_	0	root	_	_
46	on	on	IN	IN	_	49	case	_	_
47	four	four	CD	CD	_	49	nummod	_	_
48	cis-acting	cis-acting	JJ	JJ	_	49	amod	_	_
49	elements	element	NNS	NNS	_	45	nmod	_	_
50	:	:	:	:	_	45	punct	_	_
51	a	a	DT	DT	_	55	det	_	_
52	single	single	JJ	JJ	_	55	amod	_	_
53	kappa	kappa	NN	NN	_	55	compound	_	_
54	B	b	NN	NN	_	55	compound	_	_
55	site	site	NN	NN	_	45	dep	_	_
56	,	,	,	,	_	55	punct	_	_
57	two	two	CD	CD	_	60	nummod	_	_
58	purine-rich	purine-rich	JJ	JJ	_	60	amod	_	_
59	binding	bind	VBG	VBG	_	60	amod	_	_
60	sites	site	NNS	NNS	_	55	conj	_	_
61	,	,	,	,	_	60	punct	_	_
62	PuB1	pub1	NN	NN	_	60	appos	_	_
63	and	and	CC	CC	_	62	cc	_	_
64	PuB2	pub2	NN	NN	_	62	conj	_	_
65	,	,	,	,	_	55	punct	_	_
66	and	and	CC	CC	_	55	cc	_	_
67	a	a	DT	DT	_	69	det	_	_
68	pets	pets	NN	NN	_	69	compound	_	_
69	site	site	NN	NN	_	55	conj	_	_
70	.	.	.	.	_	45	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	cis-acting	cis-acting	JJ	JJ	_	8	amod	_	_
8	element	element	NN	NN	_	4	dobj	_	_
9	within	within	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	HIV-2	hiv-2	NN	NN	_	12	compound	_	_
12	enhancer	enhancer	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	immediately	immediately	RB	RB	_	15	advmod	_	_
15	upstream	upstream	JJ	JJ	_	12	advmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	kappa	kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	designated	designate	VBN	VBN	_	12	acl	_	_
23	peri-kappa	peri-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	22	xcomp	_	_
25	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	site	site	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	conserved	conserve	VBN	VBN	_	0	root	_	_
5	among	among	IN	IN	_	6	case	_	_
6	isolates	isolate	NNS	NNS	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	HIV-2	hiv-2	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	15	det	_	_
11	closely	closely	RB	RB	_	13	advmod	_	_
12	related	related	JJ	JJ	_	13	amod	_	_
13	simian	simian	JJ	JJ	_	15	amod	_	_
14	immunodeficiency	immunodeficiency	NN	NN	_	15	compound	_	_
15	virus	virus	NN	NN	_	8	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	transfection	transfection	NN	NN	_	19	compound	_	_
19	assays	assay	NNS	NNS	_	20	nsubj	_	_
20	show	show	VBP	VBP	_	4	conj	_	_
21	this	this	DT	DT	_	22	det	_	_
22	site	site	NN	NN	_	20	dobj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	mediate	mediate	VB	VB	_	20	xcomp	_	_
25	HIV-2	hiv-2	NN	NN	_	26	compound	_	_
26	enhancer	enhancer	NN	NN	_	27	compound	_	_
27	activation	activation	NN	NN	_	24	dobj	_	_
28	following	follow	VBG	VBG	_	29	case	_	_
29	stimulation	stimulation	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	monocytic	monocytic	JJ	JJ	_	29	nmod	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	31	cc	_	_
34	T-cell	t-cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	31	conj	_	_
36	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	description	description	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	HIV-2	hiv-2	NN	NN	_	10	compound	_	_
9	enhancer	enhancer	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	5	nmod	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	displays	display	VBZ	VBZ	_	10	acl:relcl	_	_
13	such	such	JJ	JJ	_	15	amod	_	_
14	monocyte	monocyte	NN	NN	_	15	compound	_	_
15	specificity	specificity	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	no	no	DT	DT	_	21	neg	_	_
19	comparable	comparable	JJ	JJ	_	21	amod	_	_
20	enhancer	enhancer	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	25	nsubjpass	_	_
22	has	have	VBZ	VBZ	_	25	aux	_	_
23	been	be	VBN	VBN	_	25	auxpass	_	_
24	clearly	clearly	RB	RB	_	25	advmod	_	_
25	defined	define	VBN	VBN	_	5	conj	_	_
26	for	for	IN	IN	_	27	case	_	_
27	HIV-1	hiv-1	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	While	while	IN	IN	_	16	mark	_	_
2	a	a	DT	DT	_	6	det	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	s	s	NNS	NNS	_	16	nsubj	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	from	from	IN	IN	_	12	case	_	_
9	both	both	CC	CC	_	12	cc:preconj	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	binds	bind	VBZ	VBZ	_	26	advcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	peri-kappa	peri-kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	16	dobj	_	_
21	,	,	,	,	_	26	punct	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	25	amod	_	_
23	mobility	mobility	NN	NN	_	25	compound	_	_
24	shift	shift	NN	NN	_	25	compound	_	_
25	assays	assay	NNS	NNS	_	26	nsubj	_	_
26	suggest	suggest	VBP	VBP	_	0	root	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	either	either	CC	CC	_	31	dep	_	_
29	a	a	DT	DT	_	31	det	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	protein	protein	NN	NN	_	32	nsubj	_	_
32	binds	bind	VBZ	VBZ	_	26	ccomp	_	_
33	to	to	TO	TO	_	35	case	_	_
34	this	this	DT	DT	_	35	det	_	_
35	site	site	NN	NN	_	32	nmod	_	_
36	in	in	IN	IN	_	37	case	_	_
37	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
38	versus	versus	CC	CC	_	37	cc	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	37	conj	_	_
41	or	or	CC	CC	_	32	cc	_	_
42	that	that	IN	IN	_	49	mark	_	_
43	the	the	DT	DT	_	44	det	_	_
44	protein	protein	NN	NN	_	49	nsubj	_	_
45	recognizing	recognize	VBG	VBG	_	44	acl	_	_
46	this	this	DT	DT	_	48	det	_	_
47	enhancer	enhancer	NN	NN	_	48	compound	_	_
48	element	element	NN	NN	_	45	dobj	_	_
49	undergoes	undergo	VBZ	VBZ	_	32	conj	_	_
50	differential	differential	JJ	JJ	_	51	amod	_	_
51	modification	modification	NN	NN	_	49	dobj	_	_
52	in	in	IN	IN	_	53	case	_	_
53	monocytes	monocyte	NNS	NNS	_	51	nmod	_	_
54	and	and	CC	CC	_	53	cc	_	_
55	T	t	NN	NN	_	56	compound	_	_
56	cells	cell	NNS	NNS	_	53	conj	_	_
57	,	,	,	,	_	26	punct	_	_
58	thus	thus	RB	RB	_	59	advmod	_	_
59	supporting	support	VBG	VBG	_	26	xcomp	_	_
60	the	the	DT	DT	_	62	det	_	_
61	transfection	transfection	NN	NN	_	62	compound	_	_
62	data	datum	NNS	NNS	_	59	dobj	_	_
63	.	.	.	.	_	26	punct	_	_

1	Further	further	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	while	while	IN	IN	_	13	mark	_	_
4	specific	specific	JJ	JJ	_	6	amod	_	_
5	constitutive	constitutive	JJ	JJ	_	4	dep	_	_
6	binding	binding	NN	NN	_	13	nsubjpass	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	peri-kappa	peri-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	seen	see	VBN	VBN	_	21	dep	_	_
14	in	in	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	stimulation	stimulation	NN	NN	_	21	nsubj	_	_
18	with	with	IN	IN	_	20	case	_	_
19	phorbol	phorbol	NN	NN	_	20	compound	_	_
20	esters	ester	NNS	NNS	_	17	nmod	_	_
21	induces	induce	VBZ	VBZ	_	0	root	_	_
22	additional	additional	JJ	JJ	_	25	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	specific	specific	JJ	JJ	_	22	dep	_	_
25	binding	binding	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	21	punct	_	_

1	Understanding	understand	VBG	VBG	_	12	csubj	_	_
2	the	the	DT	DT	_	4	det	_	_
3	monocyte-specific	monocyte-specific	JJ	JJ	_	4	amod	_	_
4	function	function	NN	NN	_	1	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	peri-kappa	peri-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	ultimately	ultimately	RB	RB	_	12	advmod	_	_
12	provide	provide	VB	VB	_	0	root	_	_
13	insight	insight	NN	NN	_	12	dobj	_	_
14	into	into	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	different	different	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	13	nmod	_	_
18	monocytes	monocyte	NNS	NNS	_	22	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	play	play	VBP	VBP	_	17	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	HIV	hiv	NN	NN	_	25	compound	_	_
25	pathogenesis	pathogenesis	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	Inhibitory	inhibitory	JJ	JJ	_	2	amod	_	_
2	action	action	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nm23	nm23	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	7	case	_	_
7	induction	induction	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	differentiation	differentiation	NN	NN	_	7	compound	_	_
6	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	3	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	I-factor	i-factor	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	16	case	_	_
12	mouse	mouse	NN	NN	_	16	compound	_	_
13	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	M1	m1	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	3	nmod	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	murine	murine	JJ	JJ	_	20	amod	_	_
20	homolog	homolog	NN	NN	_	3	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	human	human	JJ	JJ	_	26	amod	_	_
24	nm23-H2	nm23-h2	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	product	product	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	nm23	nm23	NN	NN	_	2	compound	_	_
2	genes	gene	NNS	NNS	_	3	nsubj	_	_
3	encode	encode	VBP	VBP	_	0	root	_	_
4	proteins	protein	NNS	NNS	_	3	dobj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	participate	participate	VBP	VBP	_	4	acl:relcl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	tumor	tumor	NN	NN	_	10	compound	_	_
9	metastasis	metastasis	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	in	in	IN	IN	_	16	case	_	_
13	various	various	JJ	JJ	_	16	amod	_	_
14	fundamental	fundamental	JJ	JJ	_	16	amod	_	_
15	cellular	cellular	JJ	JJ	_	14	dep	_	_
16	processes	process	NNS	NNS	_	10	conj	_	_
17	,	,	,	,	_	3	punct	_	_
18	although	although	IN	IN	_	25	mark	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	mechanisms	mechanism	NNS	NNS	_	25	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	action	action	NN	NN	_	20	nmod	_	_
23	are	be	VBP	VBP	_	25	cop	_	_
24	still	still	RB	RB	_	25	advmod	_	_
25	unknown	unknown	JJ	JJ	_	3	advcl	_	_
26	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	all	all	DT	DT	_	4	det	_	_
3	nm23	nm23	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	5	nsubj	_	_
5	contain	contain	VBP	VBP	_	18	advcl	_	_
6	nucleoside	nucleoside	NN	NN	_	11	compound	_	_
7	diphosphate	diphosphate	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	NDP	ndp	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	5	dobj	_	_
13	,	,	,	,	_	18	punct	_	_
14	it	it	PRP	PRP	_	18	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	18	aux	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	established	establish	VBN	VBN	_	0	root	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	enzyme	enzyme	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	23	nsubj	_	_
23	mediated	mediate	VBD	VBD	_	18	ccomp	_	_
24	the	the	DT	DT	_	26	det	_	_
25	various	various	JJ	JJ	_	26	amod	_	_
26	functions	function	NNS	NNS	_	23	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	nm23	nm23	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	experiment	experiment	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	nm23	nm23	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	nmod	_	_
13	on	on	IN	IN	_	17	case	_	_
14	various	various	JJ	JJ	_	17	amod	_	_
15	differentiation	differentiation	NN	NN	_	17	compound	_	_
16	induction	induction	NN	NN	_	17	compound	_	_
17	systems	system	NNS	NNS	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	leukemic	leukemic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	including	include	VBG	VBG	_	23	case	_	_
23	HL-60	hl-60	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	U937	u937	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	HEL/S	hel/s	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	KU812F	ku812f	NN	NN	_	23	conj	_	_
30	,	,	,	,	_	23	punct	_	_
31	K562	k562	NN	NN	_	23	conj	_	_
32	,	,	,	,	_	23	punct	_	_
33	and	and	CC	CC	_	23	cc	_	_
34	HEL	hel	NN	NN	_	23	conj	_	_
35	cells	cell	NNS	NNS	_	23	dep	_	_
36	.	.	.	.	_	7	punct	_	_

1	Native	native	JJ	JJ	_	6	amod	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	erythrocyte	erythrocyte	NN	NN	_	6	compound	_	_
4	NDP	ndp	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	7	nsubj	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HEL	hel	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	KU812	ku812	NN	NN	_	14	conj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	K562	k562	NN	NN	_	14	conj	_	_
19	cells	cell	NNS	NNS	_	14	dep	_	_
20	,	,	,	,	_	9	punct	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	9	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	induction	induction	NN	NN	_	9	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	monocytic	monocytic	JJ	JJ	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	granulocytic	granulocytic	JJ	JJ	_	26	conj	_	_
29	differentiation	differentiation	NN	NN	_	26	dep	_	_
30	of	of	IN	IN	_	31	case	_	_
31	HL-60	hl-60	NN	NN	_	26	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	U937	u937	NN	NN	_	31	conj	_	_
34	and	and	CC	CC	_	31	cc	_	_
35	HEL/S	hel/s	NN	NN	_	31	conj	_	_
36	cells	cell	NNS	NNS	_	31	dep	_	_
37	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	erythroid	erythroid	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	HEL	hel	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	recombinant	recombinant	JJ	JJ	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	nm23-H1	nm23-h1	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	-H2	-h2	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	mouse	mouse	NN	NN	_	12	appos	_	_
17	nm23-M1	nm23-m1	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	16	punct	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	-M2	-m2	NN	NN	_	16	conj	_	_
21	proteins	protein	NNS	NNS	_	12	dep	_	_
22	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	both	both	CC	CC	_	7	cc:preconj	_	_
4	the	the	DT	DT	_	7	dep	_	_
5	mutant	mutant	JJ	JJ	_	7	amod	_	_
6	nm23-H2His	nm23-h2his	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	28	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	truncated	truncate	VBN	VBN	_	11	amod	_	_
10	nm23-H2	nm23-h2	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	7	conj	_	_
12	containing	contain	VBG	VBG	_	7	acl	_	_
13	N-terminal	n-terminal	JJ	JJ	_	17	amod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	1-60	1-60	CD	CD	_	17	nummod	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	peptide	peptide	NN	NN	_	12	dobj	_	_
18	,	,	,	,	_	7	punct	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	do	do	VBP	VBP	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	have	have	VB	VB	_	7	acl:relcl	_	_
23	NDP	ndp	NN	NN	_	24	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	22	dobj	_	_
26	,	,	,	,	_	7	punct	_	_
27	also	also	RB	RB	_	28	advmod	_	_
28	inhibited	inhibit	VBD	VBD	_	0	root	_	_
29	erythroid	erythroid	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	HEL	hel	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	28	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	1	1	LS	LS	_	17	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	differentiation	differentiation	NN	NN	_	11	compound	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	17	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	I-factor/nm23	i-factor/nm23	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	restricted	restricted	JJ	JJ	_	3	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	M1	m1	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	2	2	LS	LS	_	32	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	the	the	DT	DT	_	30	det	_	_
29	inhibitory	inhibitory	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	exhibited	exhibit	VBN	VBN	_	17	ccomp	_	_
33	without	without	IN	IN	_	35	case	_	_
34	species	species	NNS	NNS	_	35	compound	_	_
35	specificity	specificity	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	17	punct	_	_
37	and	and	CC	CC	_	17	cc	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	3	3	LS	LS	_	51	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	the	the	DT	DT	_	44	det	_	_
42	differentiation	differentiation	NN	NN	_	44	compound	_	_
43	inhibitory	inhibitory	JJ	JJ	_	44	amod	_	_
44	activity	activity	NN	NN	_	51	nsubj	_	_
45	of	of	IN	IN	_	49	case	_	_
46	the	the	DT	DT	_	49	det	_	_
47	nm23/NDP	nm23/ndp	NN	NN	_	49	compound	_	_
48	kinase	kinase	NN	NN	_	49	compound	_	_
49	protein	protein	NN	NN	_	44	nmod	_	_
50	is	be	VBZ	VBZ	_	51	cop	_	_
51	independent	independent	JJ	JJ	_	17	conj	_	_
52	of	of	IN	IN	_	55	case	_	_
53	its	its	PRP$	PRP$	_	55	nmod:poss	_	_
54	enzyme	enzyme	NN	NN	_	55	compound	_	_
55	activity	activity	NN	NN	_	51	nmod	_	_
56	and	and	CC	CC	_	51	cc	_	_
57	requires	require	VBZ	VBZ	_	51	conj	_	_
58	the	the	DT	DT	_	59	det	_	_
59	presence	presence	NN	NN	_	57	dobj	_	_
60	of	of	IN	IN	_	62	case	_	_
61	N-terminal	n-terminal	JJ	JJ	_	62	amod	_	_
62	peptides	peptide	NNS	NNS	_	59	nmod	_	_
63	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	conserved	conserve	VBN	VBN	_	3	amod	_	_
3	motif	motif	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	promoters	promoter	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	several	several	JJ	JJ	_	9	amod	_	_
9	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
10	expressed	express	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	Th2-type	th2-type	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	conserved	conserve	VBN	VBN	_	8	amod	_	_
8	motif	motif	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	promoters	promoter	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	several	several	JJ	JJ	_	15	amod	_	_
14	T-cell-expressed	t-cell-expressed	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
16	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	interleukin-2	interleukin-2	NN	NN	_	15	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	-4	-4	CD	CD	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	-5	-5	CD	CD	_	18	conj	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	-13	-13	CD	CD	_	18	conj	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	human	human	JJ	JJ	_	18	conj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	mouse	mouse	NN	NN	_	26	conj	_	_
29	granulocyte/macrophage-colony	granulocyte/macrophage-colony	NN	NN	_	31	compound	_	_
30	stimulating	stimulating	JJ	JJ	_	31	amod	_	_
31	factor	factor	NN	NN	_	26	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	GM-CSF	gm-csf	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
36	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	core	core	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	2	dobj	_	_
6	CTTGG	cttgg	NN	NN	_	8	compound	_	_
7	...	...	:	:	_	8	punct	_	_
8	CCAAG	ccaag	NN	NN	_	5	dep	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	present	present	JJ	JJ	_	5	acl:relcl	_	_
12	as	as	IN	IN	_	13	case	_	_
13	part	part	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	larger	larger	JJR	JJR	_	13	nmod	_	_
16	palindromic	palindromic	JJ	JJ	_	17	amod	_	_
17	sequences	sequence	NNS	NNS	_	15	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	each	each	DT	DT	_	20	det	_	_
20	gene	gene	NN	NN	_	11	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	they	they	PRP	PRP	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	interact	interact	VB	VB	_	2	ccomp	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	new	new	JJ	JJ	_	10	amod	_	_
10	family	family	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	trans-acting	trans-acting	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	GM-CSF	gm-csf	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	9	nsubj	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	strong	strong	JJ	JJ	_	12	amod	_	_
12	positive	positive	JJ	JJ	_	13	amod	_	_
13	effect	effect	NN	NN	_	9	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	by	by	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	human	human	JJ	JJ	_	26	amod	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	16	nmod	_	_
27	Jurkat	jurkat	NN	NN	_	28	compound	_	_
28	J6	j6	NN	NN	_	26	dep	_	_
29	upon	upon	IN	IN	_	30	case	_	_
30	stimulation	stimulation	NN	NN	_	16	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	DNA	dna	NN	NN	_	5	compound	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	this	this	DT	DT	_	8	det	_	_
8	sequence	sequence	NN	NN	_	10	nsubj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	give	give	VB	VB	_	0	root	_	_
11	either	either	CC	CC	_	15	cc:preconj	_	_
12	six	six	CD	CD	_	15	nummod	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	specific	specific	JJ	JJ	_	13	dep	_	_
15	bands	band	NNS	NNS	_	10	dobj	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	competed	compete	VBN	VBN	_	15	acl:relcl	_	_
19	out	out	RP	RP	_	18	compound:prt	_	_
20	by	by	IN	IN	_	22	case	_	_
21	different	different	JJ	JJ	_	22	amod	_	_
22	parts	part	NNS	NNS	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	sequence	sequence	NN	NN	_	22	nmod	_	_
26	or	or	CC	CC	_	15	cc	_	_
27	one	one	CD	CD	_	29	nummod	_	_
28	specific	specific	JJ	JJ	_	29	amod	_	_
29	band	band	NN	NN	_	15	conj	_	_
30	which	which	WDT	WDT	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	competed	compete	VBN	VBN	_	29	acl:relcl	_	_
33	out	out	RP	RP	_	32	compound:prt	_	_
34	by	by	IN	IN	_	35	case	_	_
35	each	each	DT	DT	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	inverted	invert	VBN	VBN	_	39	amod	_	_
39	repeats	repeat	NNS	NNS	_	35	nmod	_	_
40	,	,	,	,	_	10	punct	_	_
41	depending	depend	VBG	VBG	_	45	case	_	_
42	on	on	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	reconstitution	reconstitution	NN	NN	_	45	compound	_	_
45	conditions	condition	NNS	NNS	_	10	advcl	_	_
46	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	genes	gene	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	core	core	NN	NN	_	7	compound	_	_
7	sequences	sequence	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	separated	separate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	integer	integer	NN	NN	_	12	compound	_	_
12	numbers	number	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	helical	helical	JJ	JJ	_	15	amod	_	_
15	turns	turn	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Considering	consider	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	6	det	_	_
3	strong	strong	JJ	JJ	_	4	amod	_	_
4	positive	positive	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	1	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	element	element	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	presence	presence	NN	NN	_	6	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	several	several	JJ	JJ	_	17	amod	_	_
15	T-cell-expressed	t-cell-expressed	JJ	JJ	_	17	amod	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	1	punct	_	_
19	it	it	PRP	PRP	_	22	nsubj	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	crucial	crucial	JJ	JJ	_	1	parataxis	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	coordinated	coordinate	VBN	VBN	_	26	amod	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	cytokines	cytokine	NNS	NNS	_	26	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	helper	helper	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	26	nmod	_	_
34	.	.	.	.	_	1	punct	_	_

1	Hematopoietic	hematopoietic	JJ	JJ	_	2	amod	_	_
2	lineage	lineage	NN	NN	_	3	compound	_	_
3	commitment	commitment	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	role	role	NN	NN	_	3	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	focuses	focus	VBZ	VBZ	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	roles	role	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
12	lineage	lineage	NN	NN	_	13	compound	_	_
13	commitment	commitment	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	brief	brief	JJ	JJ	_	3	amod	_	_
3	introduction	introduction	NN	NN	_	12	nsubjpass	_	_
4	to	to	TO	TO	_	6	case	_	_
5	lineage	lineage	NN	NN	_	6	compound	_	_
6	commitment	commitment	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	asymmetric	asymmetric	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	division	division	NN	NN	_	6	conj	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	followed	follow	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	discussion	discussion	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	methods	method	NNS	NNS	_	15	nmod	_	_
19	used	use	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	identify	identify	VB	VB	_	19	xcomp	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	21	dobj	_	_
24	important	important	JJ	JJ	_	23	amod	_	_
25	in	in	IN	IN	_	26	mark	_	_
26	specifying	specify	VBG	VBG	_	24	advcl	_	_
27	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	types	type	NNS	NNS	_	26	dobj	_	_
30	.	.	.	.	_	12	punct	_	_

1	Next	next	RB	RB	_	3	advmod	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	presented	present	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	discussion	discussion	NN	NN	_	3	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	use	use	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	embryonic	embryonic	JJ	JJ	_	12	amod	_	_
11	stem	stem	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	analysis	analysis	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	use	use	NN	NN	_	8	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	targeted	target	VBN	VBN	_	26	amod	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	disruption	disruption	NN	NN	_	22	nmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	analyze	analyze	VB	VB	_	22	acl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	role	role	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factors	factor	NNS	NNS	_	30	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	hematopoiesis	hematopoiesis	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	27	advmod	_	_
2	,	,	,	,	_	27	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	status	status	NN	NN	_	27	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	our	we	PRP$	PRP$	_	8	nmod:poss	_	_
7	current	current	JJ	JJ	_	8	amod	_	_
8	knowledge	knowledge	NN	NN	_	4	nmod	_	_
9	concerning	concern	VBG	VBG	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	roles	role	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	commitment	commitment	NN	NN	_	11	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	erythroid	erythroid	JJ	JJ	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	myeloid	myeloid	JJ	JJ	_	19	conj	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	lymphoid	lymphoid	JJ	JJ	_	19	conj	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	types	type	NNS	NNS	_	19	dep	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	summarized	summarize	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	E1A	e1a	NN	NN	_	2	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	susceptibility	susceptibility	NN	NN	_	4	dobj	_	_
6	to	to	TO	TO	_	7	case	_	_
7	killing	killing	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	NK	nk	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	following	follow	VBG	VBG	_	12	case	_	_
12	immortalization	immortalization	NN	NN	_	4	nmod	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	12	cc	_	_
15	adenovirus	adenovirus	NN	NN	_	16	compound	_	_
16	infection	infection	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Adenovirus	adenovirus	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Ad	ad	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	infection	infection	NN	NN	_	10	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	E1A	e1a	NN	NN	_	8	compound	_	_
8	transfection	transfection	NN	NN	_	5	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	model	model	VB	VB	_	10	xcomp	_	_
13	changes	change	NNS	NNS	_	12	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	susceptibility	susceptibility	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	NK	nk	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	killing	killing	NN	NN	_	15	nmod	_	_
20	caused	cause	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	transient	transient	JJ	JJ	_	20	nmod	_	_
23	vs	vs	CC	CC	_	22	cc	_	_
24	stable	stable	JJ	JJ	_	22	conj	_	_
25	E1A	e1a	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	dep	_	_
27	in	in	IN	IN	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Only	only	RB	RB	_	5	advmod	_	_
2	stably	stably	RB	RB	_	5	advmod	_	_
3	transfected	transfect	VBN	VBN	_	5	amod	_	_
4	target	target	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	cytolytic	cytolytic	JJ	JJ	_	8	amod	_	_
8	susceptibility	susceptibility	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	despite	despite	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	equivalent	equivalent	JJ	JJ	_	14	amod	_	_
14	levels	level	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	E1A	e1a	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	Ad-infected	ad-infected	JJ	JJ	_	20	amod	_	_
20	targets	target	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inability	inability	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	E1A	e1a	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	products	product	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	induce	induce	VB	VB	_	2	acl	_	_
9	cytolytic	cytolytic	JJ	JJ	_	10	amod	_	_
10	susceptibility	susceptibility	NN	NN	_	8	dobj	_	_
11	during	during	IN	IN	_	12	case	_	_
12	infection	infection	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	explained	explain	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
19	effect	effect	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	viral	viral	JJ	JJ	_	22	amod	_	_
22	infection	infection	NN	NN	_	19	nmod	_	_
23	on	on	IN	IN	_	27	case	_	_
24	otherwise	otherwise	RB	RB	_	25	advmod	_	_
25	susceptible	susceptible	JJ	JJ	_	27	amod	_	_
26	target	target	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	19	nmod	_	_
28	or	or	CC	CC	_	19	cc	_	_
29	by	by	IN	IN	_	32	case	_	_
30	viral	viral	JJ	JJ	_	31	amod	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	effects	effect	NNS	NNS	_	19	conj	_	_
33	on	on	IN	IN	_	38	case	_	_
34	class	class	NN	NN	_	37	compound	_	_
35	I	i	CD	CD	_	37	nummod	_	_
36	MHC	mhc	NN	NN	_	37	compound	_	_
37	antigen	antigen	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	32	nmod	_	_
39	on	on	IN	IN	_	41	case	_	_
40	target	target	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	differential	differential	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	E1A	e1a	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytolytic	cytolytic	JJ	JJ	_	10	amod	_	_
10	phenotypes	phenotype	NNS	NNS	_	3	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	infected	infected	JJ	JJ	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	stably	stably	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBN	VBN	_	12	conj	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	dep	_	_
18	suggests	suggest	VBZ	VBZ	_	0	root	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	NK	nk	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	23	nsubj	_	_
23	provide	provide	VBP	VBP	_	18	ccomp	_	_
24	an	a	DT	DT	_	27	det	_	_
25	effective	effective	JJ	JJ	_	26	amod	_	_
26	immunologic	immunologic	JJ	JJ	_	27	amod	_	_
27	barrier	barrier	NN	NN	_	23	dobj	_	_
28	against	against	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	dep	_	_
30	in	in	FW	FW	_	32	amod	_	_
31	vivo	vivo	FW	FW	_	30	dep	_	_
32	survival	survival	NN	NN	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	neoplastic	neoplastic	JJ	JJ	_	35	amod	_	_
35	progression	progression	NN	NN	_	32	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	E1A-immortalized	e1a-immortalized	JJ	JJ	_	38	amod	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	that	that	WDT	WDT	_	41	nsubj	_	_
40	may	may	MD	MD	_	41	aux	_	_
41	emerge	emerge	VB	VB	_	27	acl:relcl	_	_
42	from	from	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	reservoir	reservoir	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	48	case	_	_
46	persistently	persistently	RB	RB	_	48	advmod	_	_
47	infected	infected	JJ	JJ	_	48	amod	_	_
48	cells	cell	NNS	NNS	_	44	nmod	_	_
49	in	in	IN	IN	_	52	case	_	_
50	the	the	DT	DT	_	52	det	_	_
51	human	human	JJ	JJ	_	52	amod	_	_
52	host	host	NN	NN	_	48	nmod	_	_
53	.	.	.	.	_	18	punct	_	_

1	Distinct	distinct	JJ	JJ	_	3	amod	_	_
2	signaling	signaling	NN	NN	_	3	compound	_	_
3	properties	property	NNS	NNS	_	4	nsubj	_	_
4	identify	identify	VBP	VBP	_	0	root	_	_
5	functionally	functionally	RB	RB	_	6	advmod	_	_
6	different	different	JJ	JJ	_	8	amod	_	_
7	CD4	cd4	NN	NN	_	8	compound	_	_
8	epitopes	epitope	NNS	NNS	_	4	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CD4	cd4	NN	NN	_	3	compound	_	_
3	coreceptor	coreceptor	NN	NN	_	4	nsubj	_	_
4	interacts	interact	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	non-polymorphic	non-polymorphic	JJ	JJ	_	7	amod	_	_
7	regions	region	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	major	major	JJ	JJ	_	14	amod	_	_
10	histocompatibility	histocompatibility	NN	NN	_	14	compound	_	_
11	complex	complex	NN	NN	_	14	compound	_	_
12	class	class	NN	NN	_	14	compound	_	_
13	II	ii	CD	CD	_	14	nummod	_	_
14	molecules	molecule	NNS	NNS	_	7	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	antigen-presenting	antigen-presenting	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	contributes	contribute	VBZ	VBZ	_	4	conj	_	_
20	to	to	TO	TO	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	CD4	cd4	NN	NN	_	8	compound	_	_
8	triggering	triggering	NN	NN	_	5	nmod	_	_
9	on	on	IN	IN	_	13	case	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	activating	activating	NN	NN	_	13	compound	_	_
13	signals	signal	NNS	NNS	_	5	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	lymphoma	lymphoma	NN	NN	_	17	compound	_	_
17	model	model	NN	NN	_	3	nmod	_	_
18	using	use	VBG	VBG	_	17	acl	_	_
19	monoclonal	monoclonal	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	18	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	mAb	mab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	recognize	recognize	VBP	VBP	_	20	acl:relcl	_	_
26	different	different	JJ	JJ	_	28	amod	_	_
27	CD4	cd4	NN	NN	_	28	compound	_	_
28	epitopes	epitope	NNS	NNS	_	25	dobj	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	CD4	cd4	NN	NN	_	5	compound	_	_
5	triggering	triggering	NN	NN	_	6	nsubj	_	_
6	delivers	deliver	VBZ	VBZ	_	2	ccomp	_	_
7	signals	signal	NNS	NNS	_	6	dobj	_	_
8	capable	capable	JJ	JJ	_	7	amod	_	_
9	of	of	IN	IN	_	10	mark	_	_
10	activating	activate	VBG	VBG	_	8	advcl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	NF-AT	nf-at	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	10	dobj	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	14	acl:relcl	_	_
18	for	for	IN	IN	_	21	case	_	_
19	interleukin-2	interleukin-2	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Whereas	whereas	IN	IN	_	10	mark	_	_
2	different	different	JJ	JJ	_	4	amod	_	_
3	anti-CD4	anti-cd4	JJ	JJ	_	4	amod	_	_
4	mAb	mab	NN	NN	_	10	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	gp120	gp120	NN	NN	_	4	conj	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	all	all	DT	DT	_	10	advmod	_	_
10	trigger	trigger	VB	VB	_	35	advcl	_	_
11	activation	activation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	protein	protein	NN	NN	_	16	compound	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	kinases	kinase	NNS	NNS	_	11	nmod	_	_
17	p56lck	p56lck	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	p59fyn	p59fyn	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	phosphorylation	phosphorylation	NN	NN	_	11	conj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	Shc	shc	NN	NN	_	26	compound	_	_
25	adaptor	adaptor	NN	NN	_	26	compound	_	_
26	protein	protein	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	mediates	mediate	VBZ	VBZ	_	26	acl:relcl	_	_
30	signals	signal	NNS	NNS	_	29	dobj	_	_
31	to	to	TO	TO	_	32	case	_	_
32	Ras	ras	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	35	punct	_	_
34	they	they	PRP	PRP	_	35	nsubj	_	_
35	differed	differ	VBD	VBD	_	0	root	_	_
36	significantly	significantly	RB	RB	_	35	advmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
39	ability	ability	NN	NN	_	35	nmod	_	_
40	to	to	TO	TO	_	41	mark	_	_
41	activate	activate	VB	VB	_	39	acl	_	_
42	NF-AT	nf-at	NN	NN	_	41	dobj	_	_
43	.	.	.	.	_	35	punct	_	_

1	Lack	lack	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	full	full	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NF-AT	nf-at	NN	NN	_	4	nmod	_	_
7	could	could	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	correlated	correlate	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	dramatically	dramatically	RB	RB	_	13	advmod	_	_
13	reduced	reduce	VBN	VBN	_	14	amod	_	_
14	capacity	capacity	NN	NN	_	9	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	14	acl	_	_
17	calcium	calcium	NN	NN	_	18	compound	_	_
18	flux	flux	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	could	could	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	complemented	complement	VBN	VBN	_	9	conj	_	_
23	with	with	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	calcium	calcium	NN	NN	_	26	compound	_	_
26	ionophore	ionophore	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	distinct	distinct	JJ	JJ	_	6	amod	_	_
6	epitopes	epitope	NNS	NNS	_	3	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD4	cd4	NN	NN	_	10	compound	_	_
10	coreceptor	coreceptor	NN	NN	_	6	nmod	_	_
11	involved	involve	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Ras/protein	ras/protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	calcium	calcium	NN	NN	_	21	compound	_	_
21	pathways	pathway	NNS	NNS	_	13	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	3	amod	_	_
2	E-selectin	e-selectin	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	requires	require	VBZ	VBZ	_	0	root	_	_
5	continuous	continuous	JJ	JJ	_	6	amod	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	LPS	lps	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	4	conj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	bactericidal/permeability-increasing	bactericidal/permeability-increasing	JJ	JJ	_	14	amod	_	_
14	protein	protein	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Endothelial	endothelial	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	stimulated	stimulate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	5	case	_	_
5	LPS	lps	NN	NN	_	3	nmod	_	_
6	express	express	VBP	VBP	_	0	root	_	_
7	E-selectin	e-selectin	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	7	acl:relcl	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	mediating	mediate	VBG	VBG	_	10	advcl	_	_
16	neutrophil	neutrophil	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	15	dobj	_	_
18	during	during	IN	IN	_	19	case	_	_
19	inflammation	inflammation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	E-selectin	e-selectin	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	induced	induce	VBN	VBN	_	0	root	_	_
4	within	within	IN	IN	_	6	case	_	_
5	1-2	1-2	CD	CD	_	6	nummod	_	_
6	h	h	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	peaks	peak	VBZ	VBZ	_	3	conj	_	_
9	at	at	IN	IN	_	11	case	_	_
10	4-6	4-6	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	gradually	gradually	RB	RB	_	15	advmod	_	_
15	returns	return	VBZ	VBZ	_	3	conj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	basal	basal	JJ	JJ	_	18	amod	_	_
18	level	level	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	21	case	_	_
20	24	24	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	rBPI21	rbpi21	NN	NN	_	15	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	recombinant	recombinant	JJ	JJ	_	6	amod	_	_
5	N-terminal	n-terminal	JJ	JJ	_	6	amod	_	_
6	fragment	fragment	NN	NN	_	1	appos	_	_
7	of	of	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	bactericidal/permeability-increasing	bactericidal/permeability-increasing	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	BPI	bpi	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	1	punct	_	_
15	inhibited	inhibit	VBD	VBD	_	0	root	_	_
16	LPS-induced	lps-induced	JJ	JJ	_	18	amod	_	_
17	E-selectin	e-selectin	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	dobj	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	added	add	VBN	VBN	_	15	advcl	_	_
21	at	at	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	same	same	JJ	JJ	_	24	amod	_	_
24	time	time	NN	NN	_	34	nmod	_	_
25	as	as	IN	IN	_	24	acl	_	_
26	,	,	,	,	_	34	punct	_	_
27	and	and	CC	CC	_	34	cc	_	_
28	up	up	IN	IN	_	30	dep	_	_
29	to	to	TO	TO	_	28	mwe	_	_
30	6	6	CD	CD	_	31	nummod	_	_
31	h	h	NN	NN	_	34	conj	_	_
32	after	after	IN	IN	_	31	case	_	_
33	,	,	,	,	_	34	punct	_	_
34	LPS	lps	NN	NN	_	20	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	Delayed	delay	VBN	VBN	_	2	amod	_	_
2	administration	administration	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	rBPI21	rbpi21	NN	NN	_	2	nmod	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	affected	affect	VBD	VBD	_	0	root	_	_
7	LPS-mediated	lps-mediated	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	appos	_	_
16	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	3	compound	_	_
2	to	to	TO	TO	_	3	dep	_	_
3	4	4	CD	CD	_	4	nummod	_	_
4	h	h	NN	NN	_	22	nsubj	_	_
5	following	follow	VBG	VBG	_	7	case	_	_
6	LPS	lps	NN	NN	_	7	compound	_	_
7	addition	addition	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	when	when	WRB	WRB	_	17	advmod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	17	nsubjpass	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	already	already	RB	RB	_	17	advmod	_	_
17	activated	activate	VBN	VBN	_	4	acl:relcl	_	_
18	,	,	,	,	_	22	punct	_	_
19	addition	addition	NN	NN	_	22	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	rBPI21	rbpi21	NN	NN	_	19	nmod	_	_
22	resulted	result	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	marked	marked	JJ	JJ	_	25	amod	_	_
25	reduction	reduction	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	25	nmod	_	_
29	detectable	detectable	JJ	JJ	_	25	amod	_	_
30	at	at	IN	IN	_	34	case	_	_
31	4	4	CD	CD	_	34	nummod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	6	6	CD	CD	_	31	conj	_	_
34	h	h	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	endothelial	endothelial	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	7	nsubj	_	_
7	requires	require	VBZ	VBZ	_	3	ccomp	_	_
8	continuous	continuous	JJ	JJ	_	9	amod	_	_
9	presence	presence	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	LPS	lps	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	rBPI21	rbpi21	NN	NN	_	15	nsubj	_	_
15	acts	act	VBZ	VBZ	_	7	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	reverse	reverse	VB	VB	_	15	xcomp	_	_
18	LPS-mediated	lps-mediated	JJ	JJ	_	20	amod	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	dobj	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	interrupting	interrupt	VBG	VBG	_	17	advcl	_	_
23	the	the	DT	DT	_	26	det	_	_
24	on-going	on-going	JJ	JJ	_	26	amod	_	_
25	LPS	lps	NN	NN	_	26	compound	_	_
26	signal	signal	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Does	do	VBZ	VBZ	_	12	aux	_	_
2	thyroidectomy	thyroidectomy	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	radioactive	radioactive	JJ	JJ	_	6	amod	_	_
5	iodine	iodine	NN	NN	_	6	compound	_	_
6	therapy	therapy	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	or	or	CC	CC	_	2	cc	_	_
9	antithyroid	antithyroid	JJ	JJ	_	11	amod	_	_
10	drug	drug	NN	NN	_	11	compound	_	_
11	treatment	treatment	NN	NN	_	2	conj	_	_
12	alter	alter	VB	VB	_	0	root	_	_
13	reactivity	reactivity	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	patients	patient	NNS	NNS	_	13	nmod	_	_
16	'	'	POS	POS	_	15	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	dep	_	_
19	to	to	TO	TO	_	20	case	_	_
20	epitopes	epitope	NNS	NNS	_	13	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	thyrotropin	thyrotropin	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	autoimmune	autoimmune	JJ	JJ	_	27	amod	_	_
26	thyroid	thyroid	NN	NN	_	27	compound	_	_
27	diseases	disease	NNS	NNS	_	13	nmod	_	_
28	?	?	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	treatment	treatment	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	thyroid	thyroid	NN	NN	_	8	compound	_	_
7	antibody	antibody	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	reactivity	reactivity	NN	NN	_	8	conj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	thyroid	thyroid	NN	NN	_	15	compound	_	_
15	antigens	antigen	NNS	NNS	_	12	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	studied	study	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	15	15	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	17	nmod	_	_
21	with	with	IN	IN	_	24	case	_	_
22	Graves	graves	NN	NN	_	24	nmod:poss	_	_
23	'	'	POS	POS	_	24	case	_	_
24	disease	disease	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	GD	gd	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	before	before	IN	IN	_	31	nmod	_	_
29	and	and	CC	CC	_	31	cc	_	_
30	after	after	IN	IN	_	31	conj	_	_
31	thyroidectomy	thyroidectomy	NN	NN	_	20	nmod	_	_
32	,	,	,	,	_	20	punct	_	_
33	19	19	CD	CD	_	34	nummod	_	_
34	patients	patient	NNS	NNS	_	20	conj	_	_
35	with	with	IN	IN	_	36	case	_	_
36	GD	gd	NN	NN	_	34	nmod	_	_
37	before	before	IN	IN	_	45	nmod	_	_
38	and	and	CC	CC	_	45	cc	_	_
39	after	after	IN	IN	_	45	conj	_	_
40	radioactive	radioactive	JJ	JJ	_	41	amod	_	_
41	iodine	iodine	NN	NN	_	45	compound	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	RAI	rai	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	therapy	therapy	NN	NN	_	34	nmod	_	_
46	,	,	,	,	_	20	punct	_	_
47	and	and	CC	CC	_	20	cc	_	_
48	9	9	CD	CD	_	49	nummod	_	_
49	patients	patient	NNS	NNS	_	20	conj	_	_
50	maintained	maintain	VBD	VBD	_	49	acl	_	_
51	euthyroid	euthyroid	JJ	JJ	_	50	xcomp	_	_
52	on	on	IN	IN	_	54	case	_	_
53	antithyroid	antithyroid	JJ	JJ	_	54	amod	_	_
54	drugs	drug	NNS	NNS	_	51	nmod	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	ATD	atd	NN	NN	_	54	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	.	.	.	.	_	17	punct	_	_

1	Twenty	twenty	CD	CD	_	2	nummod	_	_
2	subjects	subject	NNS	NNS	_	12	nsubj	_	_
3	matched	matched	JJ	JJ	_	2	amod	_	_
4	for	for	IN	IN	_	5	case	_	_
5	age	age	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	sex	sex	NN	NN	_	5	conj	_	_
8	without	without	IN	IN	_	11	case	_	_
9	known	known	JJ	JJ	_	11	amod	_	_
10	thyroid	thyroid	NN	NN	_	11	compound	_	_
11	disease	disease	NN	NN	_	3	nmod	_	_
12	served	serve	VBD	VBD	_	0	root	_	_
13	as	as	IN	IN	_	14	case	_	_
14	controls	control	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	GD	gd	NN	NN	_	3	compound	_	_
3	patients	patient	NNS	NNS	_	38	nmod	_	_
4	,	,	,	,	_	38	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	responses	response	NNS	NNS	_	38	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PBMC	pbmc	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	TSH	tsh	NN	NN	_	24	compound	_	_
17	receptor	receptor	NN	NN	_	24	compound	_	_
18	(	(	-LRB-	-LRB-	_	24	punct	_	_
19	TSHR	tshr	NN	NN	_	24	compound	_	_
20	)	)	-RRB-	-RRB-	_	24	punct	_	_
21	-specific	-specific	JJ	JJ	_	24	amod	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	11	conj	_	_
25	to	to	TO	TO	_	30	case	_	_
26	recombinant	recombinant	JJ	JJ	_	30	amod	_	_
27	human	human	JJ	JJ	_	30	amod	_	_
28	TSHR	tshr	NN	NN	_	30	compound	_	_
29	extracellular	extracellular	JJ	JJ	_	30	amod	_	_
30	domain	domain	NN	NN	_	6	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	thyroglobulin	thyroglobulin	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	30	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	TSHR	tshr	NN	NN	_	36	compound	_	_
36	peptides	peptide	NNS	NNS	_	30	conj	_	_
37	were	be	VBD	VBD	_	38	auxpass	_	_
38	examined	examine	VBN	VBN	_	0	root	_	_
39	on	on	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	day	day	NN	NN	_	38	dep	_	_
42	of	of	IN	IN	_	43	case	_	_
43	surgery	surgery	NN	NN	_	41	nmod	_	_
44	or	or	CC	CC	_	43	cc	_	_
45	RAI	rai	NN	NN	_	46	compound	_	_
46	therapy	therapy	NN	NN	_	43	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	day	day	NN	NN	_	41	appos	_	_
49	0	0	CD	CD	_	48	nummod	_	_
50	)	)	-RRB-	-RRB-	_	48	punct	_	_
51	and	and	CC	CC	_	41	cc	_	_
52	also	also	RB	RB	_	41	conj	_	_
53	6-8	6-8	CD	CD	_	54	nummod	_	_
54	weeks	week	NNS	NNS	_	41	conj	_	_
55	and	and	CC	CC	_	54	cc	_	_
56	3-6	3-6	CD	CD	_	57	nummod	_	_
57	months	month	NNS	NNS	_	54	conj	_	_
58	thereafter	thereafter	RB	RB	_	54	advmod	_	_
59	.	.	.	.	_	38	punct	_	_

1	Reactivity	reactivity	NN	NN	_	8	nsubj	_	_
2	to	to	TO	TO	_	4	case	_	_
3	TSHR	tshr	NN	NN	_	4	compound	_	_
4	peptides	peptide	NNS	NNS	_	1	nmod	_	_
5	before	before	IN	IN	_	6	case	_	_
6	surgery	surgery	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	heterogeneous	heterogeneous	JJ	JJ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	spanned	span	VBD	VBD	_	8	conj	_	_
11	the	the	DT	DT	_	14	det	_	_
12	entire	entire	JJ	JJ	_	14	amod	_	_
13	extracellular	extracellular	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	8	punct	_	_

1	Six	six	CD	CD	_	3	compound	_	_
2	to	to	TO	TO	_	3	dep	_	_
3	8	8	CD	CD	_	4	nummod	_	_
4	weeks	week	NNS	NNS	_	26	nmod	_	_
5	after	after	IN	IN	_	4	case	_	_
6	subtotal	subtotal	JJ	JJ	_	7	amod	_	_
7	thyroidectomy	thyroidectomy	NN	NN	_	4	dep	_	_
8	,	,	,	,	_	26	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	26	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	'	'	POS	POS	_	12	case	_	_
14	PBMC	pbmc	NN	NN	_	12	dep	_	_
15	responding	respond	VBG	VBG	_	12	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	any	any	DT	DT	_	18	det	_	_
18	peptide	peptide	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	average	average	JJ	JJ	_	22	amod	_	_
22	number	number	NN	NN	_	10	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	recognized	recognize	VBN	VBN	_	25	amod	_	_
25	peptides	peptide	NNS	NNS	_	22	nmod	_	_
26	decreased	decrease	VBD	VBD	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	further	further	JJ	JJ	_	3	amod	_	_
3	decrease	decrease	NN	NN	_	13	nsubjpass	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	reactivity	reactivity	NN	NN	_	3	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	TSHR	tshr	NN	NN	_	11	compound	_	_
11	peptides	peptide	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	3-6	3-6	CD	CD	_	15	nummod	_	_
15	months	month	NNS	NNS	_	13	nmod	_	_
16	after	after	IN	IN	_	15	case	_	_
17	surgery	surgery	NN	NN	_	15	dep	_	_
18	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	responses	response	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PBMC	pbmc	NN	NN	_	2	nmod	_	_
5	from	from	IN	IN	_	8	case	_	_
6	Graves	graves	NN	NN	_	8	nmod:poss	_	_
7	'	'	POS	POS	_	8	case	_	_
8	patients	patient	NNS	NNS	_	4	nmod	_	_
9	before	before	IN	IN	_	11	case	_	_
10	RAI	rai	NN	NN	_	11	compound	_	_
11	therapy	therapy	NN	NN	_	8	nmod	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	less	less	JJR	JJR	_	0	root	_	_
14	than	than	IN	IN	_	15	case	_	_
15	those	those	DT	DT	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	presurgical	presurgical	JJ	JJ	_	19	amod	_	_
19	group	group	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Six	six	CD	CD	_	3	compound	_	_
2	to	to	TO	TO	_	3	dep	_	_
3	8	8	CD	CD	_	4	nummod	_	_
4	weeks	week	NNS	NNS	_	24	nmod	_	_
5	after	after	IN	IN	_	4	case	_	_
6	RAI	rai	NN	NN	_	7	compound	_	_
7	therapy	therapy	NN	NN	_	4	dep	_	_
8	,	,	,	,	_	24	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	24	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	responding	respond	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	any	any	DT	DT	_	16	det	_	_
16	peptide	peptide	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	average	average	JJ	JJ	_	20	amod	_	_
20	number	number	NN	NN	_	10	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	recognized	recognize	VBN	VBN	_	23	amod	_	_
23	peptides	peptide	NNS	NNS	_	20	nmod	_	_
24	increased	increase	VBD	VBD	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Three	three	CD	CD	_	3	compound	_	_
2	to	to	TO	TO	_	3	dep	_	_
3	6	6	CD	CD	_	4	nummod	_	_
4	months	month	NNS	NNS	_	15	nmod	_	_
5	after	after	IN	IN	_	4	case	_	_
6	RAI	rai	NN	NN	_	4	dep	_	_
7	,	,	,	,	_	15	punct	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	15	nsubj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	TSHR	tshr	NN	NN	_	13	compound	_	_
13	peptides	peptide	NNS	NNS	_	10	nmod	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	less	less	JJR	JJR	_	0	root	_	_
16	than	than	IN	IN	_	19	case	_	_
17	those	those	DT	DT	_	19	det	_	_
18	6-8	6-8	CD	CD	_	19	nummod	_	_
19	weeks	week	NNS	NNS	_	15	nmod	_	_
20	after	after	IN	IN	_	22	case	_	_
21	RAI	rai	NN	NN	_	22	compound	_	_
22	therapy	therapy	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	but	but	CC	CC	_	15	cc	_	_
25	still	still	RB	RB	_	26	advmod	_	_
26	higher	higher	JJR	JJR	_	15	conj	_	_
27	than	than	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	values	value	NNS	NNS	_	26	nmod	_	_
30	on	on	IN	IN	_	31	case	_	_
31	day	day	NN	NN	_	29	nmod	_	_
32	0	0	CD	CD	_	31	nummod	_	_
33	.	.	.	.	_	15	punct	_	_

1	Responses	response	NNS	NNS	_	15	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PBMC	pbmc	NN	NN	_	1	nmod	_	_
4	from	from	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	GD	gd	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	maintained	maintain	VBD	VBD	_	5	acl	_	_
10	euthyroid	euthyroid	JJ	JJ	_	9	xcomp	_	_
11	on	on	IN	IN	_	12	case	_	_
12	ATD	atd	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	lower	lower	JJR	JJR	_	0	root	_	_
16	than	than	IN	IN	_	17	case	_	_
17	those	those	DT	DT	_	15	nmod	_	_
18	before	before	IN	IN	_	19	case	_	_
19	surgery	surgery	NN	NN	_	17	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	RAI	rai	NN	NN	_	22	compound	_	_
22	therapy	therapy	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reactivity	reactivity	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	groups	group	NNS	NNS	_	6	nmod	_	_
10	reflected	reflect	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	12	det	_	_
12	pattern	pattern	NN	NN	_	10	dobj	_	_
13	similar	similar	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	PBMC	pbmc	NN	NN	_	13	nmod	_	_
16	after	after	IN	IN	_	17	case	_	_
17	treatment	treatment	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	TSHR	tshr	NN	NN	_	2	compound	_	_
2	antibody	antibody	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	microsomal	microsomal	JJ	JJ	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	2	conj	_	_
6	levels	level	NNS	NNS	_	2	dep	_	_
7	decreased	decrease	VBD	VBD	_	0	root	_	_
8	after	after	IN	IN	_	9	case	_	_
9	surgery	surgery	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	increased	increase	VBD	VBD	_	7	conj	_	_
13	after	after	IN	IN	_	15	case	_	_
14	RAI	rai	NN	NN	_	15	compound	_	_
15	therapy	therapy	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	18	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	recognized	recognize	VBN	VBN	_	8	amod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	'	'	POS	POS	_	10	case	_	_
12	PBMC	pbmc	NN	NN	_	10	dep	_	_
13	before	before	IN	IN	_	14	case	_	_
14	RAI	rai	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	surgery	surgery	NN	NN	_	14	conj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	reflect	reflect	VB	VB	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	long	long	JJ	JJ	_	24	amod	_	_
23	term	term	NN	NN	_	24	compound	_	_
24	therapy	therapy	NN	NN	_	20	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	ATD	atd	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	patients	patient	NNS	NNS	_	24	nmod	_	_
30	before	before	IN	IN	_	31	case	_	_
31	RAI	rai	NN	NN	_	29	nmod	_	_
32	vs.	vs.	CC	CC	_	24	cc	_	_
33	the	the	DT	DT	_	35	det	_	_
34	shorter	shorter	JJR	JJR	_	35	amod	_	_
35	period	period	NN	NN	_	24	conj	_	_
36	in	in	IN	IN	_	37	case	_	_
37	patients	patient	NNS	NNS	_	35	nmod	_	_
38	before	before	IN	IN	_	39	case	_	_
39	surgery	surgery	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	decreased	decrease	VBN	VBN	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	reactivity	reactivity	NN	NN	_	14	nsubj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	thyroid	thyroid	NN	NN	_	8	compound	_	_
8	antigens	antigen	NNS	NNS	_	5	nmod	_	_
9	after	after	IN	IN	_	10	case	_	_
10	thyroidectomy	thyroidectomy	NN	NN	_	5	nmod	_	_
11	could	could	MD	MD	_	14	aux	_	_
12	be	be	VB	VB	_	14	cop	_	_
13	the	the	DT	DT	_	14	det	_	_
14	result	result	NN	NN	_	0	root	_	_
15	of	of	IN	IN	_	16	case	_	_
16	removal	removal	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	major	major	JJ	JJ	_	20	amod	_	_
20	part	part	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	thyroid	thyroid	NN	NN	_	24	compound	_	_
24	gland	gland	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	16	cc	_	_
26	redistribution	redistribution	NN	NN	_	16	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	suppressor-inducer	suppressor-inducer	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	increased	increase	VBN	VBN	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	response	response	NN	NN	_	12	nsubj	_	_
6	after	after	IN	IN	_	8	case	_	_
7	RAI	rai	NN	NN	_	8	compound	_	_
8	therapy	therapy	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	probably	probably	RB	RB	_	12	advmod	_	_
11	epitope	epitope	NN	NN	_	12	nmod:npmod	_	_
12	specific	specific	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	rather	rather	RB	RB	_	12	cc	_	_
15	than	than	IN	IN	_	14	mwe	_	_
16	a	a	DT	DT	_	17	det	_	_
17	response	response	NN	NN	_	12	conj	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	whole	whole	JJ	JJ	_	22	amod	_	_
21	TSHR	tshr	NN	NN	_	22	compound	_	_
22	molecule	molecule	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Synchronous	synchronous	JJ	JJ	_	2	amod	_	_
2	recognition	recognition	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	peptides	peptide	NNS	NNS	_	2	nmod	_	_
5	158-176	158-176	CD	CD	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	248-263	248-263	CD	CD	_	4	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	important	important	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	development	development	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GD	gd	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	loss	loss	NN	NN	_	30	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	recognition	recognition	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	one	one	CD	CD	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	epitopes	epitope	NNS	NNS	_	22	nmod	_	_
26	may	may	MD	MD	_	30	aux	_	_
27	be	be	VB	VB	_	30	cop	_	_
28	an	a	DT	DT	_	30	det	_	_
29	early	early	JJ	JJ	_	30	amod	_	_
30	sign	sign	NN	NN	_	9	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	remission	remission	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	a	a	DT	DT	_	36	det	_	_
36	predictor	predictor	NN	NN	_	30	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	euthyroidism	euthyroidism	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	9	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	roles	role	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	Oct-2A	oct-2a	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	13	det	_	_
10	high	high	JJ	JJ	_	13	amod	_	_
11	mobility	mobility	NN	NN	_	13	compound	_	_
12	group	group	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	7	conj	_	_
14	I/Y	i/y	NN	NN	_	13	dep	_	_
15	in	in	IN	IN	_	18	case	_	_
16	HLA-DRA	hla-dra	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	2	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	class	class	NN	NN	_	7	compound	_	_
3	II	ii	CD	CD	_	7	nummod	_	_
4	major	major	JJ	JJ	_	7	amod	_	_
5	histocompatibility	histocompatibility	NN	NN	_	7	compound	_	_
6	complex	complex	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	10	nsubjpass	_	_
8	HLA-DRA	hla-dra	NN	NN	_	7	dep	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	appos	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	antigen-presenting	antigen-presenting	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	13	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	HLA-DRA	hla-dra	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	inducible	inducible	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	types	type	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	interferon-gamma	interferon-gamma	NN	NN	_	8	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	lymphoid-specific	lymphoid-specific	JJ	JJ	_	9	amod	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	Oct-2A	oct-2a	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	3	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	critical	critical	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	HLA-DRA	hla-dra	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	10	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	class	class	NN	NN	_	23	compound	_	_
20	II-positive	ii-positive	JJ	JJ	_	23	amod	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	10	punct	_	_
25	and	and	CC	CC	_	10	cc	_	_
26	that	that	IN	IN	_	36	mark	_	_
27	the	the	DT	DT	_	31	det	_	_
28	high	high	JJ	JJ	_	31	amod	_	_
29	mobility	mobility	NN	NN	_	31	compound	_	_
30	group	group	NN	NN	_	31	compound	_	_
31	protein	protein	NN	NN	_	36	nsubj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	HMG	hmg	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	I/Y	i/y	NN	NN	_	31	dep	_	_
36	binds	bind	VBZ	VBZ	_	10	conj	_	_
37	to	to	TO	TO	_	39	case	_	_
38	multiple	multiple	JJ	JJ	_	39	amod	_	_
39	sites	site	NNS	NNS	_	36	nmod	_	_
40	within	within	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	DRA	dra	NN	NN	_	43	compound	_	_
43	promoter	promoter	NN	NN	_	39	nmod	_	_
44	,	,	,	,	_	39	punct	_	_
45	including	include	VBG	VBG	_	49	case	_	_
46	the	the	DT	DT	_	49	det	_	_
47	Oct-2A	oct-2a	NN	NN	_	49	compound	_	_
48	binding	binding	NN	NN	_	49	compound	_	_
49	site	site	NN	NN	_	39	nmod	_	_
50	.	.	.	.	_	3	punct	_	_

1	Coexpression	coexpression	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HMG	hmg	NN	NN	_	4	compound	_	_
4	I/Y	i/y	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Oct-2	oct-2	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	1	nmod	_	_
10	lacking	lack	VBG	VBG	_	9	acl	_	_
11	Oct-2	oct-2	NN	NN	_	10	dobj	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	HLA-DRA	hla-dra	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	and	and	CC	CC	_	12	cc	_	_
22	in	in	FW	FW	_	25	amod	_	_
23	vitro	vitro	FW	FW	_	22	dep	_	_
24	DNA-binding	dna-binding	JJ	JJ	_	25	amod	_	_
25	studies	study	NNS	NNS	_	26	nsubj	_	_
26	reveal	reveal	VBP	VBP	_	12	conj	_	_
27	that	that	IN	IN	_	30	mark	_	_
28	HMG	hmg	NN	NN	_	30	nsubj	_	_
29	I/Y	i/y	NN	NN	_	28	dep	_	_
30	stimulates	stimulate	VBZ	VBZ	_	26	ccomp	_	_
31	Oct-2A	oct-2a	NN	NN	_	32	compound	_	_
32	binding	binding	NN	NN	_	30	dobj	_	_
33	to	to	TO	TO	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	HLA-DRA	hla-dra	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Oct-2A	oct-2a	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	HMG	hmg	NN	NN	_	6	compound	_	_
6	I/Y	i/y	NN	NN	_	3	conj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	synergize	synergize	VB	VB	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	activate	activate	VB	VB	_	8	xcomp	_	_
11	HLA-DRA	hla-dra	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	Oct-2A	oct-2a	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	involved	involve	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HLA-DRA	hla-dra	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	HeLa	hela	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	but	but	CC	CC	_	7	cc	_	_
21	antisense	antisense	JJ	JJ	_	23	amod	_	_
22	HMG	hmg	NN	NN	_	23	compound	_	_
23	I/Y	i/y	NN	NN	_	25	nsubj	_	_
24	dramatically	dramatically	RB	RB	_	25	advmod	_	_
25	decreases	decrease	VBZ	VBZ	_	7	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	level	level	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	induction	induction	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	sets	set	NNS	NNS	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	2	ccomp	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	modes	mode	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HLA-DRA	hla-dra	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	HMG	hmg	NN	NN	_	22	compound	_	_
22	I/Y	i/y	NN	NN	_	25	nsubj	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	important	important	JJ	JJ	_	10	conj	_	_
26	for	for	IN	IN	_	29	case	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	cell-specific	cell-specific	JJ	JJ	_	29	amod	_	_
29	expression	expression	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	25	punct	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	is	be	VBZ	VBZ	_	33	cop	_	_
33	essential	essential	JJ	JJ	_	25	conj	_	_
34	for	for	IN	IN	_	36	case	_	_
35	IFN-gamma	ifn-gamma	NN	NN	_	36	compound	_	_
36	induction	induction	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	Interleukin	interleukin	NN	NN	_	3	nsubj	_	_
2	4	4	CD	CD	_	1	nummod	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	signal	signal	NN	NN	_	6	compound	_	_
6	transducer	transducer	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	activator	activator	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	6	amod	_	_
10	transcription	transcription	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	Stat	stat	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	protein	protein	NN	NN	_	6	dep	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	interacts	interact	VBZ	VBZ	_	6	acl:relcl	_	_
17	with	with	IN	IN	_	22	case	_	_
18	an	a	DT	DT	_	22	det	_	_
19	interferon-gamma	interferon-gamma	NN	NN	_	22	compound	_	_
20	activation	activation	NN	NN	_	22	compound	_	_
21	site-like	site-like	JJ	JJ	_	22	amod	_	_
22	sequence	sequence	NN	NN	_	16	nmod	_	_
23	upstream	upstream	RB	RB	_	22	advmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	I	i	NN	NN	_	28	compound	_	_
27	epsilon	epsilon	NN	NN	_	28	compound	_	_
28	exon	exon	NN	NN	_	23	nmod	_	_
29	in	in	IN	IN	_	34	case	_	_
30	a	a	DT	DT	_	34	det	_	_
31	human	human	JJ	JJ	_	34	amod	_	_
32	B	b	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	line	line	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	involvement	involvement	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Janus	janus	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	4	nmod	_	_
8	3	3	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	interleukin-4	interleukin-4	NN	NN	_	11	compound	_	_
11	Stat	stat	NN	NN	_	7	conj	_	_
12	.	.	.	.	_	1	punct	_	_

1	Germ	germ	NN	NN	_	4	compound	_	_
2	line	line	NN	NN	_	4	compound	_	_
3	C	c	NN	NN	_	4	compound	_	_
4	transcripts	transcript	NNS	NNS	_	7	nsubjpass	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IL-4	il-4	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	7	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	BL-2	bl-2	NN	NN	_	15	appos	_	_
18	.	.	.	.	_	7	punct	_	_

1	Utilizing	utilize	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	8	det	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	8	compound	_	_
4	activation	activation	NN	NN	_	8	compound	_	_
5	site-like	site-like	JJ	JJ	_	8	amod	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	1	dobj	_	_
9	located	located	JJ	JJ	_	8	amod	_	_
10	upstream	upstream	RB	RB	_	9	advmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	epsilon	epsilon	NN	NN	_	15	compound	_	_
15	exon	exon	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	1	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	demonstrated	demonstrate	VBD	VBD	_	1	parataxis	_	_
19	by	by	IN	IN	_	23	case	_	_
20	gel	gel	NN	NN	_	23	compound	_	_
21	mobility	mobility	NN	NN	_	23	compound	_	_
22	shift	shift	NN	NN	_	23	compound	_	_
23	assays	assay	NNS	NNS	_	18	nmod	_	_
24	that	that	IN	IN	_	26	mark	_	_
25	IL-4	il-4	NN	NN	_	26	nsubj	_	_
26	induced	induce	VBD	VBD	_	18	ccomp	_	_
27	a	a	DT	DT	_	29	det	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	cytosol	cytosol	NN	NN	_	26	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	nucleus	nucleus	NN	NN	_	32	conj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	BL-2	bl-2	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	designated	designate	VBN	VBN	_	0	root	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	NAF	naf	NNS	NNS	_	4	xcomp	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	IL-4-induced	il-4-induced	JJ	JJ	_	10	amod	_	_
9	nuclear-activating	nuclear-activating	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	6	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	identified	identify	VBN	VBN	_	4	conj	_	_
15	as	as	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphoprotein	phosphoprotein	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	translocates	translocate	VBZ	VBZ	_	18	acl:relcl	_	_
22	from	from	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cytosol	cytosol	NN	NN	_	21	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	nucleus	nucleus	NN	NN	_	21	nmod	_	_
28	upon	upon	IN	IN	_	30	case	_	_
29	IL-4	il-4	NN	NN	_	30	compound	_	_
30	treatment	treatment	NN	NN	_	21	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	these	these	DT	DT	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	characteristics	characteristic	NNS	NNS	_	20	advcl	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	signal	signal	NN	NN	_	9	compound	_	_
9	transducer	transducer	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activator	activator	NN	NN	_	17	compound	_	_
12	of	of	IN	IN	_	17	amod	_	_
13	transcription	transcription	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	Stat	stat	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	protein	protein	NN	NN	_	9	conj	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	determined	determine	VBD	VBD	_	0	root	_	_
21	whether	whether	IN	IN	_	27	mark	_	_
22	antibodies	antibody	NNS	NNS	_	25	compound	_	_
23	to	to	TO	TO	_	25	dep	_	_
24	Stat	stat	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	27	nsubj	_	_
26	will	will	MD	MD	_	27	aux	_	_
27	interfere	interfere	VB	VB	_	20	ccomp	_	_
28	with	with	IN	IN	_	31	case	_	_
29	gel	gel	NN	NN	_	31	compound	_	_
30	mobility	mobility	NN	NN	_	31	compound	_	_
31	shift	shift	NN	NN	_	27	nmod	_	_
32	and	and	CC	CC	_	20	cc	_	_
33	found	find	VBD	VBD	_	20	conj	_	_
34	that	that	IN	IN	_	53	mark	_	_
35	antibodies	antibody	NNS	NNS	_	38	compound	_	_
36	to	to	TO	TO	_	38	dep	_	_
37	IL-4	il-4	NN	NN	_	38	compound	_	_
38	Stat	stat	NN	NN	_	53	nsubj	_	_
39	,	,	,	,	_	38	punct	_	_
40	also	also	RB	RB	_	41	advmod	_	_
41	known	know	VBN	VBN	_	38	acl	_	_
42	as	as	IN	IN	_	43	case	_	_
43	Stat6	stat6	NN	NN	_	41	nmod	_	_
44	,	,	,	,	_	38	punct	_	_
45	but	but	CC	CC	_	46	cc	_	_
46	not	not	RB	RB	_	38	cc	_	_
47	antibodies	antibody	NNS	NNS	_	38	conj	_	_
48	to	to	TO	TO	_	51	case	_	_
49	other	other	JJ	JJ	_	51	amod	_	_
50	Stat	stat	NN	NN	_	51	compound	_	_
51	proteins	protein	NNS	NNS	_	47	nmod	_	_
52	,	,	,	,	_	38	punct	_	_
53	interfere	interfere	VBP	VBP	_	33	ccomp	_	_
54	with	with	IN	IN	_	56	case	_	_
55	the	the	DT	DT	_	56	det	_	_
56	formation	formation	NN	NN	_	53	nmod	_	_
57	of	of	IN	IN	_	61	case	_	_
58	the	the	DT	DT	_	61	det	_	_
59	IL-4	il-4	NN	NN	_	61	compound	_	_
60	NAF	naf	NN	NN	_	61	compound	_	_
61	complex	complex	NN	NN	_	56	nmod	_	_
62	.	.	.	.	_	20	punct	_	_

1	Congruous	congruous	JJ	JJ	_	11	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	involvement	involvement	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	Stat	stat	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	IL-4	il-4	NN	NN	_	11	nsubj	_	_
11	induced	induce	VBD	VBD	_	0	root	_	_
12	robust	robust	JJ	JJ	_	19	amod	_	_
13	Janus	janus	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	19	compound	_	_
15	3	3	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	JAK3	jak3	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	activity	activity	NN	NN	_	11	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	BL-2	bl-2	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	11	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	JAK3	jak3	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	Stat	stat	NN	NN	_	1	nmod	_	_
7	into	into	IN	IN	_	9	case	_	_
8	COS-7	cos-7	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	produced	produce	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	13	det	_	_
12	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	bound	bind	VBD	VBD	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	21	det	_	_
17	same	same	JJ	JJ	_	21	amod	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
19	activation	activation	NN	NN	_	21	compound	_	_
20	site-like	site-like	JJ	JJ	_	21	amod	_	_
21	sequence	sequence	NN	NN	_	15	dobj	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	comigrated	comigrate	VBD	VBD	_	15	conj	_	_
24	with	with	IN	IN	_	26	case	_	_
25	IL-4	il-4	NN	NN	_	26	compound	_	_
26	NAF	naf	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	31	case	_	_
28	electrophoretic	electrophoretic	JJ	JJ	_	31	amod	_	_
29	mobility	mobility	NN	NN	_	31	compound	_	_
30	shift	shift	NN	NN	_	31	compound	_	_
31	assay	assay	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	NAF	naf	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	IL-4	il-4	NN	NN	_	9	compound	_	_
9	Stat	stat	NN	NN	_	3	ccomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	activated	activate	VBN	VBN	_	9	acl:relcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	JAK3	jak3	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	13	nmod	_	_
18	to	to	TO	TO	_	21	case	_	_
19	IL-4	il-4	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	engagement	engagement	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	tyk2	tyk2	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Jak1	jak1	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	differential	differential	JJ	JJ	_	13	amod	_	_
13	assembly	assembly	NN	NN	_	5	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	STAT1	stat1	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	STAT3	stat3	NN	NN	_	19	compound	_	_
19	complexes	complex	NNS	NNS	_	16	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	2	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	monocytes	monocyte	NNS	NNS	_	23	conj	_	_
26	.	.	.	.	_	2	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	affects	affect	VBZ	VBZ	_	0	root	_	_
3	monocytes	monocyte	NNS	NNS	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	conj	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	driving	drive	VBG	VBG	_	2	advcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	progression	progression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	responsiveness	responsiveness	NN	NN	_	10	nmod	_	_
14	such	such	IN	IN	_	19	mark	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	Th2	th2	NN	NN	_	18	compound	_	_
17	lymphocyte-mediated	lymphocyte-mediated	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	19	nsubj	_	_
19	predominate	predominate	VBP	VBP	_	2	advcl	_	_
20	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	in	in	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	IL-10	il-10	NN	NN	_	14	nsubj	_	_
14	stimulates	stimulate	VBZ	VBZ	_	6	ccomp	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	transducers	transducer	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	activators	activator	NNS	NNS	_	24	compound	_	_
23	of	of	IN	IN	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	STAT1	stat1	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	20	appos	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	STAT3	stat3	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	14	punct	_	_
31	in	in	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	differential	differential	JJ	JJ	_	34	amod	_	_
34	manner	manner	NN	NN	_	14	nmod	_	_
35	such	such	IN	IN	_	44	mark	_	_
36	that	that	IN	IN	_	44	mark	_	_
37	the	the	DT	DT	_	39	det	_	_
38	relative	relative	JJ	JJ	_	39	amod	_	_
39	formation	formation	NN	NN	_	44	nsubj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	homo-	homo-	JJ	JJ	_	39	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	heterodimers	heterodimer	NNS	NNS	_	41	conj	_	_
44	varies	vary	VBZ	VBZ	_	14	advcl	_	_
45	between	between	IN	IN	_	49	case	_	_
46	the	the	DT	DT	_	49	det	_	_
47	two	two	CD	CD	_	49	nummod	_	_
48	cell	cell	NN	NN	_	49	compound	_	_
49	types	type	NNS	NNS	_	44	nmod	_	_
50	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	monocytes	monocyte	NNS	NNS	_	4	nsubj	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	novel	novel	JJ	JJ	_	9	amod	_	_
7	IL-10-stimulated	il-10-stimulated	JJ	JJ	_	9	amod	_	_
8	STAT	stat	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	4	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	an	a	DT	DT	_	12	det	_	_
12	M(r)	m(r)	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	70	70	CD	CD	_	15	nummod	_	_
15	kDa	kda	NN	NN	_	12	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	recognized	recognize	VBN	VBN	_	9	acl:relcl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	anti-STAT3	anti-stat3	JJ	JJ	_	22	amod	_	_
22	Ab	ab	NN	NN	_	18	nmod	_	_
23	but	but	CC	CC	_	18	cc	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	observed	observe	VBN	VBN	_	18	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	both	both	CC	CC	_	6	cc:preconj	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	monocytes	monocyte	NNS	NNS	_	6	conj	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	ligand-induced	ligand-induced	JJ	JJ	_	14	amod	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	tyk2	tyk2	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Jak1	jak1	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	16	cc	_	_
22	Jak2	jak2	NN	NN	_	16	conj	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	Jak3	jak3	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	9	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	modulation	modulation	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	responsiveness	responsiveness	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IL-10	il-10	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	such	such	JJ	JJ	_	12	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	result	result	VB	VB	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	17	nmod	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	differential	differential	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	STAT	stat	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	pairs	pair	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	Costimulation	costimulation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	CD4+	cd4+	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	LFA-3	lfa-3	NN	NN	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	B7	b7	NN	NN	_	8	conj	_	_
11	induce	induce	VBP	VBP	_	0	root	_	_
12	distinct	distinct	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	AP-1	ap-1	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	conj	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	earlier	earlier	RBR	RBR	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	29	mark	_	_
6	stimulation	stimulation	NN	NN	_	29	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	CD4+	cd4+	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	SEA	sea	NN	NN	_	6	nmod	_	_
14	presented	present	VBN	VBN	_	13	acl	_	_
15	on	on	IN	IN	_	23	case	_	_
16	Chinese	chinese	JJ	JJ	_	23	amod	_	_
17	hamster	hamster	NN	NN	_	23	compound	_	_
18	ovary	ovary	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	CHO	cho	NN	NN	_	23	compound	_	_
21	)	)	-RRB-	-RRB-	_	23	punct	_	_
22	-DR	-dr	NN	NN	_	23	compound	_	_
23	transfectants	transfectant	NNS	NNS	_	14	nmod	_	_
24	coexpressing	coexpress	VBG	VBG	_	23	acl	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	B7	b7	NN	NN	_	24	dobj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	LFA-3	lfa-3	NN	NN	_	26	conj	_	_
29	resulted	result	VBD	VBD	_	4	ccomp	_	_
30	in	in	IN	IN	_	33	case	_	_
31	distinct	distinct	JJ	JJ	_	33	amod	_	_
32	cytokine	cytokine	NN	NN	_	33	compound	_	_
33	profiles	profile	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	B7	b7	NN	NN	_	12	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	LFA-3	lfa-3	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	strongly	strongly	RB	RB	_	12	advmod	_	_
12	costimulated	costimulate	VBD	VBD	_	3	ccomp	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	conj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	CD4+	cd4+	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	12	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Maximal	maximal	JJ	JJ	_	2	amod	_	_
2	increase	increase	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	recorded	record	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	CHO-DR/B7/LFA-3	cho-dr/b7/lfa-3	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	suggesting	suggest	VBG	VBG	_	7	advcl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cooperative	cooperative	JJ	JJ	_	14	amod	_	_
14	effect	effect	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	B7	b7	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	LFA-3	lfa-3	NN	NN	_	16	conj	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Gel-shift	gel-shift	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	stimulation	stimulation	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	CHO-DR	cho-dr	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	staphylococcal	staphylococcal	JJ	JJ	_	15	amod	_	_
14	enterotoxin	enterotoxin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	11	conj	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	induce	induce	VB	VB	_	17	xcomp	_	_
20	significant	significant	JJ	JJ	_	21	amod	_	_
21	amounts	amount	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	whereas	whereas	IN	IN	_	34	mark	_	_
29	induction	induction	NN	NN	_	34	nsubj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	AP-1	ap-1	NN	NN	_	33	compound	_	_
32	binding	binding	NN	NN	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	29	nmod	_	_
34	required	require	VBD	VBD	_	17	advcl	_	_
35	costimulation	costimulation	NN	NN	_	34	dobj	_	_
36	.	.	.	.	_	3	punct	_	_

1	LFA-3	lfa-3	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	moderate	moderate	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AP-1	ap-1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	but	but	CC	CC	_	2	cc	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	influence	influence	VB	VB	_	2	conj	_	_
12	the	the	DT	DT	_	13	det	_	_
13	levels	level	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	while	while	IN	IN	_	22	mark	_	_
19	B7	b7	NN	NN	_	20	compound	_	_
20	costimulation	costimulation	NN	NN	_	22	nsubj	_	_
21	strongly	strongly	RB	RB	_	22	advmod	_	_
22	induced	induce	VBD	VBD	_	2	advcl	_	_
23	both	both	CC	CC	_	24	cc:preconj	_	_
24	AP-1	ap-1	NN	NN	_	22	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	substantially	substantially	RB	RB	_	27	advmod	_	_
27	enhanced	enhance	VBN	VBN	_	31	amod	_	_
28	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	proteins	protein	NNS	NNS	_	24	conj	_	_
32	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	CHO-DR/B7/LFA-3	cho-dr/b7/lfa-3	NN	NN	_	4	compound	_	_
3	triple	triple	JJ	JJ	_	4	amod	_	_
4	transfectant	transfectant	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	further	further	JJ	JJ	_	8	amod	_	_
8	increase	increase	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	AP-1	ap-1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	conj	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	10	dep	_	_
16	compared	compare	VBN	VBN	_	20	case	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	double	double	JJ	JJ	_	20	amod	_	_
20	transfectants	transfectant	NNS	NNS	_	5	advcl	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	level	level	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Oct-1	oct-1	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	remained	remain	VBD	VBD	_	0	root	_	_
8	similar	similar	JJ	JJ	_	7	xcomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	all	all	DT	DT	_	11	det	_	_
11	samples	sample	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Super-shift	super-shift	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	14	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	costimulated	costimulate	VBN	VBN	_	13	amod	_	_
11	CD4+	cd4+	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	contained	contain	VBD	VBD	_	3	ccomp	_	_
15	large	large	JJ	JJ	_	16	amod	_	_
16	amounts	amount	NNS	NNS	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	p50	p50	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	substantial	substantial	JJ	JJ	_	21	amod	_	_
21	amounts	amount	NNS	NNS	_	16	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	p65	p65	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	16	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	marginal	marginal	JJ	JJ	_	27	amod	_	_
27	levels	level	NNS	NNS	_	16	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	c-Rel	c-rel	NN	NN	_	30	compound	_	_
30	proteins	protein	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	AP-1	ap-1	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	5	nsubj	_	_
5	contained	contain	VBD	VBD	_	0	root	_	_
6	c-Jun	c-jun	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	Jun-D	jun-d	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	Fra-1	fra-1	NN	NN	_	6	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	but	but	CC	CC	_	6	cc	_	_
14	marginal	marginal	JJ	JJ	_	15	amod	_	_
15	amounts	amount	NNS	NNS	_	6	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Jun-B	jun-b	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	c-Fos	c-fos	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	B7	b7	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	LFA-3	lfa-3	NN	NN	_	7	conj	_	_
10	costimulation	costimulation	NN	NN	_	5	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	AP-1	ap-1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	partly	partly	RB	RB	_	4	advmod	_	_
4	account	account	VB	VB	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	differential	differential	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	B7	b7	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	LFA-3	lfa-3	NN	NN	_	10	conj	_	_
13	costimulation	costimulation	NN	NN	_	8	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Multiple	multiple	JJ	JJ	_	2	amod	_	_
2	signals	signal	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	6	case	_	_
6	function	function	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	human	human	JJ	JJ	_	14	amod	_	_
10	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	14	amod	_	_
11	colony-stimulating	colony-stimulating	JJ	JJ	_	14	amod	_	_
12	factor	factor	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	6	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	human	human	JJ	JJ	_	8	amod	_	_
3	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	8	amod	_	_
4	CSF	csf	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	GM-CSF	gm-csf	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	gene	gene	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	TCR	tcr	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	that	that	WDT	WDT	_	22	nsubjpass	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	mimicked	mimic	VBN	VBN	_	18	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	treatment	treatment	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	PMA	pma	NN	NN	_	24	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Ca2+	ca2+	NN	NN	_	32	compound	_	_
32	ionophore	ionophore	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	proximal	proximal	JJ	JJ	_	8	amod	_	_
6	functional	functional	JJ	JJ	_	8	amod	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	region	region	NN	NN	_	3	dobj	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	-620	-620	CD	CD	_	12	nummod	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	+34	+34	CD	CD	_	8	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	8	punct	_	_
15	as	as	RB	RB	_	8	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	a	a	DT	DT	_	20	det	_	_
19	powerful	powerful	JJ	JJ	_	20	amod	_	_
20	enhancer	enhancer	NN	NN	_	8	conj	_	_
21	located	located	JJ	JJ	_	20	amod	_	_
22	3	3	CD	CD	_	23	nummod	_	_
23	kb	kb	NN	NN	_	24	nmod:npmod	_	_
24	upstream	upstream	RB	RB	_	21	advmod	_	_
25	,	,	,	,	_	8	punct	_	_
26	both	both	DT	DT	_	30	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	26	nmod	_	_
29	are	be	VBP	VBP	_	30	auxpass	_	_
30	involved	involve	VBN	VBN	_	8	acl:relcl	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	response	response	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	gene	gene	NN	NN	_	33	nmod	_	_
37	to	to	TO	TO	_	39	case	_	_
38	TCR	tcr	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proximal	proximal	JJ	JJ	_	3	amod	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	region	region	NN	NN	_	4	dobj	_	_
7	termed	term	VBN	VBN	_	6	acl	_	_
8	CLEO	cleo	NN	NN	_	7	xcomp	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	-54	-54	CD	CD	_	12	nummod	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	-31	-31	CD	CD	_	8	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	consists	consist	VBZ	VBZ	_	6	acl:relcl	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	purine-rich	purine-rich	JJ	JJ	_	19	amod	_	_
19	element	element	NN	NN	_	15	nmod	_	_
20	abutting	abut	VBG	VBG	_	19	acl	_	_
21	an	a	DT	DT	_	28	det	_	_
22	activator	activator	NN	NN	_	28	compound	_	_
23	protein-1	protein-1	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	AP-1	ap-1	NN	NN	_	28	compound	_	_
26	)	)	-RRB-	-RRB-	_	28	punct	_	_
27	-like	-like	JJ	JJ	_	28	amod	_	_
28	site	site	NN	NN	_	20	dobj	_	_
29	,	,	,	,	_	19	punct	_	_
30	as	as	RB	RB	_	19	cc	_	_
31	well	well	RB	RB	_	30	mwe	_	_
32	as	as	IN	IN	_	30	mwe	_	_
33	an	a	DT	DT	_	42	det	_	_
34	upstream	upstream	JJ	JJ	_	42	amod	_	_
35	nuclear	nuclear	JJ	JJ	_	42	amod	_	_
36	factor-kappa	factor-kappa	NN	NN	_	42	compound	_	_
37	B	b	NN	NN	_	42	compound	_	_
38	(	(	-LRB-	-LRB-	_	42	punct	_	_
39	NF-kappa	nf-kappa	NN	NN	_	42	compound	_	_
40	B	b	NN	NN	_	42	compound	_	_
41	)	)	-RRB-	-RRB-	_	42	punct	_	_
42	site	site	NN	NN	_	19	conj	_	_
43	(	(	-LRB-	-LRB-	_	46	punct	_	_
44	-85	-85	CD	CD	_	46	nummod	_	_
45	to	to	TO	TO	_	46	dep	_	_
46	-76	-76	CD	CD	_	42	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	and	and	CC	CC	_	42	cc	_	_
49	a	a	DT	DT	_	51	det	_	_
50	CK-1	ck-1	NN	NN	_	51	compound	_	_
51	element	element	NN	NN	_	42	conj	_	_
52	(	(	-LRB-	-LRB-	_	55	punct	_	_
53	-101	-101	CD	CD	_	55	nummod	_	_
54	to	to	TO	TO	_	55	dep	_	_
55	-92	-92	CD	CD	_	51	appos	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	work	work	NN	NN	_	2	nmod	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	mutations	mutation	NNS	NNS	_	22	nsubj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	either	either	CC	CC	_	12	cc:preconj	_	_
10	the	the	DT	DT	_	12	det	_	_
11	purine-rich	purine-rich	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CLEO	cleo	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	12	nmod	_	_
17	or	or	CC	CC	_	12	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	12	conj	_	_
22	result	result	VBP	VBP	_	2	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	reduced	reduce	VBN	VBN	_	26	amod	_	_
25	PMA/Ca2+	pma/ca2+	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	35	case	_	_
28	a	a	DT	DT	_	35	det	_	_
29	620-bp	620-bp	JJ	JJ	_	35	amod	_	_
30	human	human	JJ	JJ	_	35	amod	_	_
31	GM-CSF	gm-csf	NN	NN	_	35	compound	_	_
32	promoter-	promoter-	NN	NN	_	35	compound	_	_
33	luciferase	luciferase	NN	NN	_	35	compound	_	_
34	reporter	reporter	NN	NN	_	35	compound	_	_
35	construct	construct	NN	NN	_	26	nmod	_	_
36	in	in	IN	IN	_	39	case	_	_
37	Jurkat	jurkat	NN	NN	_	39	compound	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	26	nmod	_	_
40	by	by	IN	IN	_	42	case	_	_
41	65	65	CD	CD	_	42	nummod	_	_
42	%	%	NN	NN	_	26	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	50	50	CD	CD	_	45	nummod	_	_
45	%	%	NN	NN	_	42	conj	_	_
46	,	,	,	,	_	26	punct	_	_
47	respectively	respectively	RB	RB	_	26	advmod	_	_
48	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	major	major	JJ	JJ	_	5	amod	_	_
3	inducible	inducible	JJ	JJ	_	5	amod	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	complex	complex	NN	NN	_	19	nsubj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	human	human	JJ	JJ	_	15	amod	_	_
11	CLEO	cleo	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	hCLEO	hcleo	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	element	element	NN	NN	_	7	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	an	a	DT	DT	_	19	det	_	_
18	AP-1-like	ap-1-like	JJ	JJ	_	19	amod	_	_
19	complex	complex	NN	NN	_	0	root	_	_
20	that	that	WDT	WDT	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	inducible	inducible	JJ	JJ	_	19	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	PMA	pma	NN	NN	_	22	nmod	_	_
25	alone	alone	RB	RB	_	24	advmod	_	_
26	,	,	,	,	_	22	punct	_	_
27	but	but	CC	CC	_	22	cc	_	_
28	shows	show	VBZ	VBZ	_	22	conj	_	_
29	increased	increase	VBN	VBN	_	30	amod	_	_
30	binding	binding	NN	NN	_	28	dobj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	response	response	NN	NN	_	28	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	PMA	pma	NN	NN	_	32	nmod	_	_
35	together	together	RB	RB	_	28	advmod	_	_
36	with	with	IN	IN	_	38	case	_	_
37	Ca2+	ca2+	NN	NN	_	38	compound	_	_
38	ionophore	ionophore	NN	NN	_	28	nmod	_	_
39	.	.	.	.	_	19	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	binding	binding	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	complex	complex	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	cyclosporin-sensitive	cyclosporin-sensitive	JJ	JJ	_	14	advcl	_	_
10	,	,	,	,	_	14	punct	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	inhibited	inhibit	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	second	second	JJ	JJ	_	4	amod	_	_
3	weak	weak	JJ	JJ	_	4	amod	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	complex	complex	NN	NN	_	18	nsubjpass	_	_
6	resembling	resemble	VBG	VBG	_	5	acl	_	_
7	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
8	factor	factor	NN	NN	_	12	compound	_	_
9	of	of	IN	IN	_	12	amod	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	xcomp	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NF-AT	nf-at	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	observed	observe	VBN	VBN	_	0	root	_	_
19	binding	bind	VBG	VBG	_	18	xcomp	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	hCLEO	hcleo	NN	NN	_	23	compound	_	_
23	region	region	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	18	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	7	advcl	_	_
3	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	2	dobj	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	confirmed	confirm	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	22	mark	_	_
9	AP-1	ap-1	NN	NN	_	22	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	NF-ATp	nf-atp	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	higher	higher	JJR	JJR	_	16	amod	_	_
16	order	order	NN	NN	_	9	conj	_	_
17	NF-ATp	nf-atp	NN	NN	_	19	compound	_	_
18	/AP-1	/ap-1	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	16	dep	_	_
20	could	could	MD	MD	_	22	aux	_	_
21	all	all	DT	DT	_	22	advmod	_	_
22	form	form	VB	VB	_	7	ccomp	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	hCLEO	hcleo	NN	NN	_	26	compound	_	_
26	element	element	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	7	punct	_	_
28	and	and	CC	CC	_	7	cc	_	_
29	we	we	PRP	PRP	_	32	nsubj	_	_
30	have	have	VBP	VBP	_	32	aux	_	_
31	also	also	RB	RB	_	32	advmod	_	_
32	defined	define	VBN	VBN	_	7	conj	_	_
33	the	the	DT	DT	_	35	det	_	_
34	sequence	sequence	NN	NN	_	35	compound	_	_
35	requirements	requirement	NNS	NNS	_	32	dobj	_	_
36	for	for	IN	IN	_	37	case	_	_
37	binding	binding	NN	NN	_	35	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	each	each	DT	DT	_	37	nmod	_	_
40	of	of	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	complexes	complex	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	expression	expression	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	active	active	JJ	JJ	_	9	amod	_	_
9	form	form	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	calcineurin	calcineurin	NN	NN	_	9	nmod	_	_
12	could	could	MD	MD	_	13	aux	_	_
13	substitute	substitute	VB	VB	_	2	ccomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	Ca2+	ca2+	NN	NN	_	16	compound	_	_
16	ionophore	ionophore	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	synergize	synergize	VB	VB	_	13	conj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	PMA	pma	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	activate	activate	VB	VB	_	13	xcomp	_	_
23	the	the	DT	DT	_	25	det	_	_
24	GM-CSF	gm-csf	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	22	dobj	_	_
26	,	,	,	,	_	13	punct	_	_
27	and	and	CC	CC	_	13	cc	_	_
28	conversely	conversely	RB	RB	_	33	advmod	_	_
29	that	that	IN	IN	_	33	mark	_	_
30	mutant-activated	mutant-activated	JJ	JJ	_	31	amod	_	_
31	Ras	ras	NN	NN	_	33	nsubj	_	_
32	could	could	MD	MD	_	33	aux	_	_
33	substitute	substitute	VB	VB	_	13	conj	_	_
34	for	for	IN	IN	_	35	case	_	_
35	PMA	pma	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	33	cc	_	_
37	cooperate	cooperate	VB	VB	_	33	conj	_	_
38	with	with	IN	IN	_	40	case	_	_
39	Ca2+	ca2+	NN	NN	_	40	compound	_	_
40	ionophore	ionophore	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	Co-expression	co-expression	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Ras	ras	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	calcineurin	calcineurin	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	1	punct	_	_
7	however	however	RB	RB	_	11	advmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	activate	activate	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GM-CSF	gm-csf	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	11	punct	_	_
16	but	but	CC	CC	_	11	cc	_	_
17	required	require	VBD	VBD	_	11	conj	_	_
18	the	the	DT	DT	_	20	det	_	_
19	additional	additional	JJ	JJ	_	20	amod	_	_
20	expression	expression	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	p65	p65	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	at	at	IN	IN	_	6	case	_	_
6	least	least	JJS	JJS	_	7	nmod:npmod	_	_
7	three	three	CD	CD	_	8	nummod	_	_
8	signals	signal	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	3	ccomp	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	activate	activate	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	16	det	_	_
14	GM-CSF	gm-csf	NN	NN	_	16	compound	_	_
15	proximal	proximal	JJ	JJ	_	16	amod	_	_
16	promoter	promoter	NN	NN	_	12	dobj	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	signals	signal	NNS	NNS	_	22	nsubj	_	_
22	impinge	impinge	VBP	VBP	_	10	conj	_	_
23	on	on	IN	IN	_	26	case	_	_
24	distinct	distinct	JJ	JJ	_	26	amod	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	22	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	bind	bind	VBP	VBP	_	26	acl:relcl	_	_
29	to	to	TO	TO	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	hCLEO	hcleo	NN	NN	_	35	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	NF-kappa	nf-kappa	NN	NN	_	31	conj	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	regions	region	NNS	NNS	_	28	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	promoter	promoter	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Overexpression	overexpression	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	DR-nm23	dr-nm23	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	3	appos	_	_
7	encoded	encode	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	member	member	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	nm23	nm23	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	1	punct	_	_
17	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
18	granulocyte	granulocyte	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	induces	induce	VBZ	VBZ	_	17	conj	_	_
22	apoptosis	apoptosis	NN	NN	_	21	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	32Dc13	32dc13	NN	NN	_	26	compound	_	_
25	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Chronic	chronic	JJ	JJ	_	3	amod	_	_
2	myelogenous	myelogenous	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	4	nsubj	_	_
4	evolves	evolve	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	clinically	clinically	RB	RB	_	8	advmod	_	_
8	distinct	distinct	JJ	JJ	_	9	amod	_	_
9	stages	stage	NNS	NNS	_	4	nmod	_	_
10	:	:	:	:	_	4	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	chronic	chronic	JJ	JJ	_	4	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	blast	blast	NN	NN	_	16	compound	_	_
16	crisis	crisis	NN	NN	_	12	conj	_	_
17	phase	phase	NN	NN	_	12	dep	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	changes	change	NNS	NNS	_	14	nsubj	_	_
4	associated	associate	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	chronic	chronic	JJ	JJ	_	7	amod	_	_
7	phase	phase	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	blast	blast	NN	NN	_	11	compound	_	_
10	crisis	crisis	NN	NN	_	11	compound	_	_
11	transition	transition	NN	NN	_	7	nmod	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	largely	largely	RB	RB	_	14	advmod	_	_
14	unknown	unknown	JJ	JJ	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	cDNA	cdna	NN	NN	_	6	compound	_	_
6	clone	clone	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	DR-nm23	dr-nm23	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	differentially	differentially	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	6	acl	_	_
12	in	in	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	blast-crisis	blast-crisis	JJ	JJ	_	16	amod	_	_
15	cDNA	cdna	NN	NN	_	16	compound	_	_
16	library	library	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	has	have	VBZ	VBZ	_	6	acl:relcl	_	_
20	approximately	approximately	RB	RB	_	21	advmod	_	_
21	70	70	CD	CD	_	22	dep	_	_
22	%	%	NN	NN	_	24	dep	_	_
23	sequence	sequence	NN	NN	_	24	compound	_	_
24	similarity	similarity	NN	NN	_	19	dobj	_	_
25	to	to	TO	TO	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	putative	putative	JJ	JJ	_	30	amod	_	_
28	metastatic	metastatic	JJ	JJ	_	30	amod	_	_
29	suppressor	suppressor	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	24	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	nm23-H1	nm23-h1	NN	NN	_	30	appos	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	nm23-H2	nm23-h2	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	deduced	deduce	VBN	VBN	_	6	amod	_	_
3	amino	amino	NN	NN	_	6	compound	_	_
4	acid	acid	NN	NN	_	6	compound	_	_
5	sequence	sequence	NN	NN	_	6	compound	_	_
6	similarity	similarity	NN	NN	_	19	nsubj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	encoded	encode	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	15	case	_	_
12	these	these	DT	DT	_	15	det	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	latter	latter	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	approximately	approximately	RB	RB	_	18	advmod	_	_
18	65	65	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	0	root	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	includes	include	VBZ	VBZ	_	19	conj	_	_
22	domains	domain	NNS	NNS	_	21	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	amino	amino	NN	NN	_	26	compound	_	_
25	acid	acid	NN	NN	_	26	compound	_	_
26	residues	residue	NNS	NNS	_	22	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	leucine	leucine	NN	NN	_	22	dep	_	_
30	zipper-like	zipper-like	JJ	JJ	_	29	amod	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	the	the	DT	DT	_	34	det	_	_
33	RGD	rgd	NN	NN	_	34	compound	_	_
34	domain	domain	NN	NN	_	29	conj	_	_
35	,	,	,	,	_	29	punct	_	_
36	a	a	DT	DT	_	37	det	_	_
37	serine	serine	NN	NN	_	29	appos	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	a	a	DT	DT	_	40	det	_	_
40	histidine	histidine	NN	NN	_	37	conj	_	_
41	residue	residue	NN	NN	_	37	dep	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	NH2-	nh2-	NN	NN	_	37	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	in	in	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	COOH-terminal	cooh-terminal	JJ	JJ	_	49	amod	_	_
49	portion	portion	NN	NN	_	44	conj	_	_
50	of	of	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	protein	protein	NN	NN	_	44	nmod	_	_
53	,	,	,	,	_	29	punct	_	_
54	respectively	respectively	RB	RB	_	29	advmod	_	_
55	)	)	-RRB-	-RRB-	_	29	punct	_	_
56	postulated	postulate	VBN	VBN	_	22	acl	_	_
57	to	to	TO	TO	_	59	mark	_	_
58	be	be	VB	VB	_	59	cop	_	_
59	important	important	JJ	JJ	_	56	xcomp	_	_
60	for	for	IN	IN	_	62	case	_	_
61	nm23	nm23	NN	NN	_	62	compound	_	_
62	function	function	NN	NN	_	59	nmod	_	_
63	.	.	.	.	_	19	punct	_	_

1	DR-nm23	dr-nm23	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	preferentially	preferentially	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	8	case	_	_
7	early	early	JJ	JJ	_	8	amod	_	_
8	stages	stage	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	highly	highly	RB	RB	_	16	advmod	_	_
14	purified	purify	VBN	VBN	_	16	amod	_	_
15	CD34+	cd34+	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	constitutive	constitutive	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	22	nsubj	_	_
4	in	in	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
7	precursor	precursor	NN	NN	_	10	compound	_	_
8	32Dc13	32dc13	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	growth-factor	growth-factor	NN	NN	_	15	nmod:npmod	_	_
15	dependent	dependent	JJ	JJ	_	10	acl:relcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	proliferation	proliferation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	differentiation	differentiation	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	3	punct	_	_
22	results	result	VBZ	VBZ	_	0	root	_	_
23	in	in	IN	IN	_	24	case	_	_
24	inhibition	inhibition	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	granulocytic	granulocytic	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	24	nmod	_	_
28	induced	induce	VBN	VBN	_	27	acl	_	_
29	by	by	IN	IN	_	32	case	_	_
30	granulocyte	granulocyte	NN	NN	_	32	compound	_	_
31	colony-stimulating	colony-stimulating	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	28	nmod	_	_
33	and	and	CC	CC	_	22	cc	_	_
34	causes	cause	VBZ	VBZ	_	22	conj	_	_
35	apoptotic	apoptotic	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	death	death	NN	NN	_	34	dobj	_	_
38	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	4	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	DR-nm23	dr-nm23	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	hematopoiesis	hematopoiesis	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	raise	raise	VBP	VBP	_	4	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	possibility	possibility	NN	NN	_	14	dobj	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	overexpression	overexpression	NN	NN	_	20	nsubj	_	_
20	contributes	contribute	VBZ	VBZ	_	16	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	differentiation	differentiation	NN	NN	_	23	compound	_	_
23	arrest	arrest	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	a	a	DT	DT	_	26	det	_	_
26	feature	feature	NN	NN	_	23	appos	_	_
27	of	of	IN	IN	_	29	case	_	_
28	blastic	blastic	JJ	JJ	_	29	amod	_	_
29	transformation	transformation	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	chronic	chronic	JJ	JJ	_	33	amod	_	_
32	myelogenous	myelogenous	JJ	JJ	_	33	amod	_	_
33	leukemia	leukemia	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	0	root	_	_
3	as	as	IN	IN	_	4	case	_	_
4	targets	target	NNS	NNS	_	2	nmod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	oxidative	oxidative	JJ	JJ	_	7	amod	_	_
7	signalling	signalling	NN	NN	_	4	nmod	_	_
8	during	during	IN	IN	_	10	case	_	_
9	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	previously	previously	RB	RB	_	4	advmod	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	requirement	requirement	NN	NN	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	oxidative	oxidative	JJ	JJ	_	9	amod	_	_
9	events	event	NNS	NNS	_	6	nmod	_	_
10	during	during	IN	IN	_	13	case	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	cycle	cycle	NN	NN	_	13	compound	_	_
13	entry	entry	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	hypothesised	hypothesise	VBN	VBN	_	4	conj	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	reactive	reactive	JJ	JJ	_	23	amod	_	_
22	oxygen	oxygen	NN	NN	_	23	compound	_	_
23	species	species	NNS	NNS	_	25	nsubj	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	act	act	VB	VB	_	19	ccomp	_	_
26	as	as	IN	IN	_	29	case	_	_
27	intracellular	intracellular	JJ	JJ	_	29	amod	_	_
28	signalling	signal	VBG	VBG	_	29	amod	_	_
29	agents	agent	NNS	NNS	_	25	nmod	_	_
30	during	during	IN	IN	_	32	case	_	_
31	lymphocyte	lymphocyte	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	cysteamine	cysteamine	NN	NN	_	17	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	an	a	DT	DT	_	10	det	_	_
9	aminothiol	aminothiol	NN	NN	_	10	compound	_	_
10	compound	compound	NN	NN	_	6	appos	_	_
11	with	with	IN	IN	_	13	case	_	_
12	antioxidant	antioxidant	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	used	use	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	further	further	RB	RB	_	20	advmod	_	_
20	investigate	investigate	VB	VB	_	17	xcomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	role	role	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	oxidative	oxidative	JJ	JJ	_	25	amod	_	_
25	signalling	signalling	NN	NN	_	22	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	lymphocyte	lymphocyte	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	Treatment	treatment	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	normal	normal	JJ	JJ	_	7	amod	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	cysteamine	cysteamine	NN	NN	_	1	nmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	1	advmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	inhibit	inhibit	VB	VB	_	13	xcomp	_	_
16	proliferation	proliferation	NN	NN	_	15	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	dose-dependent	dose-dependent	JJ	JJ	_	20	amod	_	_
20	manner	manner	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	with	with	IN	IN	_	26	mark	_	_
23	essentially	essentially	RB	RB	_	26	advmod	_	_
24	complete	complete	JJ	JJ	_	25	amod	_	_
25	inhibition	inhibition	NN	NN	_	26	nsubj	_	_
26	occurring	occur	VBG	VBG	_	15	advcl	_	_
27	at	at	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	dose	dose	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	400	400	CD	CD	_	32	nummod	_	_
32	microM	microm	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	limited	limited	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	first	first	JJ	JJ	_	10	amod	_	_
9	2	2	CD	CD	_	10	nummod	_	_
10	h	h	NN	NN	_	5	nmod	_	_
11	after	after	IN	IN	_	13	case	_	_
12	mitogenic	mitogenic	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	localizing	localize	VBG	VBG	_	5	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	time-frame	time-frame	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	action	action	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	cysteamine	cysteamine	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	26	case	_	_
23	within	within	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	commitment	commitment	NN	NN	_	26	compound	_	_
26	period	period	NN	NN	_	15	advcl	_	_
27	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	5	nsubj	_	_
2	therefore	therefore	RB	RB	_	5	advmod	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	of	of	IN	IN	_	5	case	_	_
5	interest	interest	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	establish	establish	VB	VB	_	5	xcomp	_	_
8	which	which	WDT	WDT	_	16	dobj	_	_
9	,	,	,	,	_	16	punct	_	_
10	if	if	IN	IN	_	11	mark	_	_
11	any	any	DT	DT	_	16	advcl	_	_
12	,	,	,	,	_	16	punct	_	_
13	commitment	commitment	NN	NN	_	14	compound	_	_
14	events	event	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	affected	affect	VBN	VBN	_	7	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	oxidative	oxidative	JJ	JJ	_	19	amod	_	_
19	signalling	signalling	NN	NN	_	16	nmod	_	_
20	during	during	IN	IN	_	23	case	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	cycle	cycle	NN	NN	_	23	compound	_	_
23	entry	entry	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Taking	take	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	4	det	_	_
3	IL-2	il-2	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	1	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	candidate	candidate	NN	NN	_	1	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	examined	examine	VBD	VBD	_	1	parataxis	_	_
11	the	the	DT	DT	_	12	det	_	_
12	effect	effect	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cysteamine	cysteamine	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	on	on	IN	IN	_	19	case	_	_
17	early	early	JJ	JJ	_	18	amod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	12	nmod	_	_
20	during	during	IN	IN	_	22	case	_	_
21	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	19	punct	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	on	on	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activity	activity	NN	NN	_	19	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	27	nmod	_	_
31	AP-1	ap-1	NN	NN	_	30	dep	_	_
32	,	,	,	,	_	31	punct	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	31	conj	_	_
35	,	,	,	,	_	31	punct	_	_
36	NF-AT	nf-at	NN	NN	_	31	conj	_	_
37	and	and	CC	CC	_	31	cc	_	_
38	Oct1	oct1	NN	NN	_	31	conj	_	_
39	,	,	,	,	_	30	punct	_	_
40	whose	whose	WP$	WP$	_	41	nmod:poss	_	_
41	functions	function	NNS	NNS	_	43	nsubjpass	_	_
42	are	be	VBP	VBP	_	43	auxpass	_	_
43	required	require	VBN	VBN	_	30	acl:relcl	_	_
44	for	for	IN	IN	_	45	case	_	_
45	expression	expression	NN	NN	_	43	nmod	_	_
46	of	of	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	IL-2	il-2	NN	NN	_	49	compound	_	_
49	mRNA	mrna	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	1	punct	_	_

1	Cysteamine	cysteamine	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	secretion	secretion	NN	NN	_	5	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-2	il-2	NN	NN	_	11	nmod	_	_
14	into	into	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	culture	culture	NN	NN	_	17	compound	_	_
17	medium	medium	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cysteamine	cysteamine	NN	NN	_	3	nmod	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	12	advmod	_	_
10	least	least	JJS	JJS	_	9	mwe	_	_
11	in	in	IN	IN	_	12	case	_	_
12	part	part	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	effect	effect	NN	NN	_	8	nmod	_	_
16	on	on	IN	IN	_	19	case	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	as	as	IN	IN	_	37	mark	_	_
22	the	the	DT	DT	_	25	det	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	activities	activity	NNS	NNS	_	37	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	AP-1	ap-1	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	conj	_	_
31	extracted	extract	VBN	VBN	_	27	acl	_	_
32	from	from	IN	IN	_	34	case	_	_
33	mitogen-stimulated	mitogen-stimulated	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	were	be	VBD	VBD	_	37	auxpass	_	_
36	significantly	significantly	RB	RB	_	37	advmod	_	_
37	inhibited	inhibit	VBN	VBN	_	8	advcl	_	_
38	by	by	IN	IN	_	40	case	_	_
39	cysteamine	cysteamine	NN	NN	_	40	compound	_	_
40	treatment	treatment	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	Oct1	oct1	NN	NN	_	8	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	NF-AT	nf-at	NN	NN	_	3	conj	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	11	nsubjpass	_	_
9	were	be	VBD	VBD	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	affected	affect	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	cysteamine	cysteamine	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	oxidative	oxidative	JJ	JJ	_	20	amod	_	_
19	signalling	signalling	NN	NN	_	20	compound	_	_
20	processes	process	NNS	NNS	_	21	nsubj	_	_
21	operate	operate	VBP	VBP	_	16	ccomp	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	selective	selective	JJ	JJ	_	25	amod	_	_
25	manner	manner	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	such	such	JJ	JJ	_	10	case	_	_
8	as	as	IN	IN	_	7	mwe	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	as	as	IN	IN	_	14	case	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	targets	target	NNS	NNS	_	2	nmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	oxidative	oxidative	JJ	JJ	_	17	amod	_	_
17	signalling	signalling	NN	NN	_	14	nmod	_	_
18	provides	provide	VBZ	VBZ	_	0	root	_	_
19	further	further	JJ	JJ	_	20	amod	_	_
20	evidence	evidence	NN	NN	_	18	dobj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	implicate	implicate	VB	VB	_	20	acl	_	_
23	oxidative	oxidative	JJ	JJ	_	24	amod	_	_
24	signalling	signalling	NN	NN	_	22	dobj	_	_
25	as	as	IN	IN	_	28	mark	_	_
26	being	be	VBG	VBG	_	28	auxpass	_	_
27	intimately	intimately	RB	RB	_	28	advmod	_	_
28	involved	involve	VBN	VBN	_	22	advcl	_	_
29	in	in	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	G0	g0	NN	NN	_	35	compound	_	_
32	to	to	TO	TO	_	33	case	_	_
33	G1	g1	NN	NN	_	31	nmod	_	_
34	phase	phase	NN	NN	_	35	compound	_	_
35	transition	transition	NN	NN	_	28	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	lymphocytes	lymphocyte	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	18	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	5'	5'	JJ	JJ	_	9	amod	_	_
4	end	end	NN	NN	_	9	compound	_	_
5	of	of	IN	IN	_	9	amod	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	thromboxane	thromboxane	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Organizational	organizational	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mapping	mapping	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	protein	protein	NN	NN	_	11	compound	_	_
7	kinase	kinase	NN	NN	_	11	compound	_	_
8	C	c	NN	NN	_	11	compound	_	_
9	--	--	:	:	_	11	punct	_	_
10	responsive	responsive	JJ	JJ	_	11	amod	_	_
11	elements	element	NNS	NNS	_	2	nmod	_	_
12	regulating	regulate	VBG	VBG	_	11	acl	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	platelets	platelet	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Platelet	platelet	NN	NN	_	3	compound	_	_
2	thromboxane	thromboxane	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	8	nsubjpass	_	_
4	are	be	VBP	VBP	_	8	auxpass	_	_
5	acutely	acutely	RB	RB	_	6	advmod	_	_
6	and	and	CC	CC	_	8	advmod	_	_
7	reversibly	reversibly	RB	RB	_	6	advmod	_	_
8	upregulated	upregulate	VBN	VBN	_	0	root	_	_
9	after	after	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	myocardial	myocardial	JJ	JJ	_	12	amod	_	_
12	infarction	infarction	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	if	if	IN	IN	_	10	mark	_	_
4	platelet	platelet	NN	NN	_	10	nsubj	_	_
5	thromboxane	thromboxane	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	4	dep	_	_
7	are	be	VBP	VBP	_	10	cop	_	_
8	under	under	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	control	control	NN	NN	_	2	advcl	_	_
11	,	,	,	,	_	2	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	isolated	isolate	VBD	VBD	_	2	parataxis	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	characterized	characterize	VBD	VBD	_	13	conj	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	genomic	genomic	JJ	JJ	_	19	amod	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	clones	clone	NNS	NNS	_	13	dobj	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	5'	5'	JJ	JJ	_	24	amod	_	_
23	flanking	flanking	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	thromboxane	thromboxane	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	exon-intron	exon-intron	JJ	JJ	_	3	amod	_	_
3	structure	structure	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	5'	5'	JJ	JJ	_	7	amod	_	_
7	portion	portion	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	thromboxane	thromboxane	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	determined	determine	VBN	VBN	_	0	root	_	_
15	initially	initially	RB	RB	_	14	advmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	comparing	compare	VBG	VBG	_	14	advcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nucleotide	nucleotide	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	5'	5'	JJ	JJ	_	26	amod	_	_
24	flanking	flanking	JJ	JJ	_	26	amod	_	_
25	genomic	genomic	JJ	JJ	_	26	amod	_	_
26	clone	clone	NN	NN	_	20	nmod	_	_
27	with	with	IN	IN	_	28	case	_	_
28	that	that	DT	DT	_	17	nmod	_	_
29	of	of	IN	IN	_	36	case	_	_
30	a	a	DT	DT	_	36	det	_	_
31	novel	novel	JJ	JJ	_	36	amod	_	_
32	human	human	JJ	JJ	_	36	amod	_	_
33	uterine	uterine	NN	NN	_	36	compound	_	_
34	thromboxane	thromboxane	NN	NN	_	36	compound	_	_
35	receptor	receptor	NN	NN	_	36	compound	_	_
36	cDNA	cdna	NN	NN	_	28	nmod	_	_
37	that	that	WDT	WDT	_	38	nsubj	_	_
38	extended	extend	VBD	VBD	_	28	acl:relcl	_	_
39	the	the	DT	DT	_	40	det	_	_
40	mRNA	mrna	NN	NN	_	38	iobj	_	_
41	141	141	CD	CD	_	42	nummod	_	_
42	bp	bp	NN	NN	_	38	dobj	_	_
43	further	further	RBR	RBR	_	42	advmod	_	_
44	upstream	upstream	RB	RB	_	42	advmod	_	_
45	than	than	IN	IN	_	51	case	_	_
46	the	the	DT	DT	_	51	det	_	_
47	previously	previously	RB	RB	_	51	advmod	_	_
48	identified	identify	VBN	VBN	_	51	amod	_	_
49	human	human	JJ	JJ	_	51	amod	_	_
50	placental	placental	JJ	JJ	_	51	amod	_	_
51	cDNA	cdna	NN	NN	_	42	nmod	_	_
52	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	major	major	JJ	JJ	_	5	amod	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	initiation	initiation	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	located	located	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	tissues	tissue	NNS	NNS	_	7	nmod	_	_
12	approximately	approximately	RB	RB	_	14	advmod	_	_
13	560	560	CD	CD	_	14	nummod	_	_
14	bp	bp	NN	NN	_	7	dep	_	_
15	upstream	upstream	JJ	JJ	_	14	amod	_	_
16	from	from	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	translation	translation	NN	NN	_	20	compound	_	_
19	initiation	initiation	NN	NN	_	20	compound	_	_
20	codon	codon	NN	NN	_	14	nmod	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	380	380	CD	CD	_	23	nummod	_	_
23	bp	bp	NN	NN	_	14	conj	_	_
24	upstream	upstream	JJ	JJ	_	23	amod	_	_
25	from	from	IN	IN	_	31	case	_	_
26	any	any	DT	DT	_	31	det	_	_
27	previously	previously	RB	RB	_	28	advmod	_	_
28	identified	identify	VBN	VBN	_	31	amod	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	initiation	initiation	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	thromboxane	thromboxane	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	neither	neither	CC	CC	_	8	cc:preconj	_	_
7	a	a	DT	DT	_	8	det	_	_
8	TATA	tata	NN	NN	_	5	dobj	_	_
9	nor	nor	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	CAAT	caat	NN	NN	_	13	compound	_	_
12	consensus	consensus	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	function	function	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	5'	5'	JJ	JJ	_	7	amod	_	_
6	flanking	flanking	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	thromboxane	thromboxane	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	evaluated	evaluate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	transfection	transfection	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	27	case	_	_
18	thromboxane	thromboxane	NN	NN	_	27	compound	_	_
19	receptor	receptor	NN	NN	_	27	compound	_	_
20	gene	gene	NN	NN	_	27	compound	_	_
21	promoter/chloramphenicol	promoter/chloramphenicol	NN	NN	_	27	compound	_	_
22	acetyltransferase	acetyltransferase	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	CAT	cat	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	chimera	chimera	NN	NN	_	27	compound	_	_
27	plasmids	plasmid	NNS	NNS	_	16	nmod	_	_
28	into	into	IN	IN	_	31	case	_	_
29	platelet-like	platelet-like	JJ	JJ	_	31	amod	_	_
30	K562	k562	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	16	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Thromboxane	thromboxane	NN	NN	_	4	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	14	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	assessed	assess	VBN	VBN	_	14	dep	_	_
8	by	by	IN	IN	_	10	case	_	_
9	CAT	cat	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	relatively	relatively	RB	RB	_	14	advmod	_	_
14	weak	weak	JJ	JJ	_	0	root	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	enhanced	enhance	VBN	VBN	_	14	conj	_	_
19	by	by	IN	IN	_	22	case	_	_
20	phorbol	phorbol	NN	NN	_	22	compound	_	_
21	ester	ester	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	5'	5'	JJ	JJ	_	6	amod	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	transfected	transfect	VBN	VBN	_	10	amod	_	_
9	K562	k562	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	gel	gel	NN	NN	_	14	compound	_	_
13	mobility	mobility	NN	NN	_	14	compound	_	_
14	shift	shift	NN	NN	_	2	conj	_	_
15	localized	localize	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	20	det	_	_
17	major	major	JJ	JJ	_	20	amod	_	_
18	phorbol	phorbol	NN	NN	_	20	compound	_	_
19	ester-responsive	ester-responsive	JJ	JJ	_	20	amod	_	_
20	motifs	motif	NNS	NNS	_	15	dobj	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	thromboxane	thromboxane	NN	NN	_	25	compound	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	20	nmod	_	_
27	to	to	TO	TO	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	cluster	cluster	NN	NN	_	15	nmod	_	_
30	of	of	IN	IN	_	38	case	_	_
31	activator	activator	NN	NN	_	38	compound	_	_
32	protein-2	protein-2	NN	NN	_	38	compound	_	_
33	(	(	-LRB-	-LRB-	_	38	punct	_	_
34	AP-2	ap-2	NN	NN	_	38	compound	_	_
35	)	)	-RRB-	-RRB-	_	38	punct	_	_
36	binding	binding	NN	NN	_	38	compound	_	_
37	consensus	consensus	NN	NN	_	38	compound	_	_
38	sites	site	NNS	NNS	_	29	nmod	_	_
39	located	located	JJ	JJ	_	38	amod	_	_
40	approximately	approximately	RB	RB	_	41	advmod	_	_
41	1.8	1.8	CD	CD	_	42	nummod	_	_
42	kb	kb	NN	NN	_	39	nmod	_	_
43	5'	5'	JJ	JJ	_	42	amod	_	_
44	from	from	IN	IN	_	42	case	_	_
45	the	the	DT	DT	_	48	det	_	_
46	transcription	transcription	NN	NN	_	48	compound	_	_
47	initiation	initiation	NN	NN	_	48	compound	_	_
48	site	site	NN	NN	_	42	dep	_	_
49	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	structure	structure	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	organization	organization	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	5'	5'	JJ	JJ	_	15	amod	_	_
15	end	end	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	thromboxane	thromboxane	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	demonstrate	demonstrate	VBP	VBP	_	7	conj	_	_
23	that	that	IN	IN	_	30	mark	_	_
24	thromboxane	thromboxane	NN	NN	_	26	compound	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	30	nsubjpass	_	_
28	can	can	MD	MD	_	30	aux	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	regulated	regulate	VBN	VBN	_	22	ccomp	_	_
31	by	by	IN	IN	_	32	case	_	_
32	activation	activation	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	protein	protein	NN	NN	_	36	compound	_	_
35	kinase	kinase	NN	NN	_	36	compound	_	_
36	C	c	NN	NN	_	32	nmod	_	_
37	via	via	IN	IN	_	38	case	_	_
38	induction	induction	NN	NN	_	30	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	an	a	DT	DT	_	43	det	_	_
41	AP-2-like	ap-2-like	JJ	JJ	_	43	amod	_	_
42	nuclear	nuclear	JJ	JJ	_	43	amod	_	_
43	factor	factor	NN	NN	_	38	nmod	_	_
44	binding	bind	VBG	VBG	_	43	acl	_	_
45	to	to	TO	TO	_	48	case	_	_
46	upstream	upstream	JJ	JJ	_	48	amod	_	_
47	promoter	promoter	NN	NN	_	48	compound	_	_
48	elements	element	NNS	NNS	_	44	nmod	_	_
49	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	25	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanism	mechanism	NN	NN	_	25	nsubj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	described	describe	VBN	VBN	_	11	amod	_	_
11	upregulation	upregulation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	platelet	platelet	NN	NN	_	15	compound	_	_
14	thromboxane	thromboxane	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	11	nmod	_	_
16	after	after	IN	IN	_	19	case	_	_
17	acute	acute	JJ	JJ	_	18	amod	_	_
18	myocardial	myocardial	JJ	JJ	_	19	amod	_	_
19	infarction	infarction	NN	NN	_	11	nmod	_	_
20	is	be	VBZ	VBZ	_	25	cop	_	_
21	increased	increase	VBN	VBN	_	25	amod	_	_
22	thromboxane	thromboxane	NN	NN	_	24	compound	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	4	ccomp	_	_
26	in	in	IN	IN	_	28	case	_	_
27	platelet-progenitor	platelet-progenitor	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Flutamide	flutamide	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	treatment	treatment	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	hirsutism	hirsutism	NN	NN	_	4	nmod	_	_
7	:	:	:	:	_	1	punct	_	_
8	long-term	long-term	JJ	JJ	_	10	amod	_	_
9	clinical	clinical	JJ	JJ	_	8	dep	_	_
10	effects	effect	NNS	NNS	_	1	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	endocrine	endocrine	JJ	JJ	_	13	amod	_	_
13	changes	change	NNS	NNS	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	androgen	androgen	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	behavior	behavior	NN	NN	_	10	conj	_	_
19	.	.	.	.	_	1	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	1	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	long-term	long-term	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	treatment	treatment	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	doses	dose	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	flutamide	flutamide	NN	NN	_	12	nmod	_	_
15	on	on	IN	IN	_	16	case	_	_
16	clinical	clinical	JJ	JJ	_	7	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	hormonal	hormonal	JJ	JJ	_	16	conj	_	_
19	parameters	parameter	NNS	NNS	_	16	dep	_	_
20	,	,	,	,	_	16	punct	_	_
21	as	as	RB	RB	_	16	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	on	on	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	androgen	androgen	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	28	compound	_	_
28	status	status	NN	NN	_	16	conj	_	_
29	,	,	,	,	_	16	punct	_	_
30	in	in	IN	IN	_	32	case	_	_
31	hirsute	hirsute	JJ	JJ	_	32	amod	_	_
32	women	woman	NNS	NNS	_	16	conj	_	_
33	.	.	.	.	_	4	punct	_	_

1	DESIGN	design	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Eighteen	eighteen	CD	CD	_	5	nummod	_	_
4	hirsute	hirsute	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	10	nsubjpass	_	_
6	with	with	IN	IN	_	8	case	_	_
7	regular	regular	JJ	JJ	_	8	amod	_	_
8	menses	menses	NNS	NNS	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	studied	study	VBN	VBN	_	1	dep	_	_
11	basally	basally	RB	RB	_	12	advmod	_	_
12	and	and	CC	CC	_	10	advmod	_	_
13	during	during	IN	IN	_	14	case	_	_
14	treatment	treatment	NN	NN	_	12	conj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	125	125	CD	CD	_	17	compound	_	_
17	mg	mg	NN	NN	_	18	amod	_	_
18	flutamide	flutamide	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	three	three	CD	CD	_	21	nummod	_	_
21	times	time	NNS	NNS	_	14	appos	_	_
22	per	per	IN	IN	_	23	case	_	_
23	day	day	NN	NN	_	21	nmod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	12	12	CD	CD	_	26	nummod	_	_
26	months	month	NNS	NNS	_	14	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	Barrier	barrier	NN	NN	_	6	nsubjpass	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	intrauterine	intrauterine	JJ	JJ	_	1	conj	_	_
4	contraception	contraception	NN	NN	_	1	dep	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	during	during	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	study	study	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	sexually	sexually	RB	RB	_	12	advmod	_	_
12	active	active	JJ	JJ	_	13	amod	_	_
13	women	woman	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Safety	safety	NN	NN	_	2	compound	_	_
2	parameters	parameter	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	assessed	assess	VBN	VBN	_	0	root	_	_
5	throughout	throughout	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	study	study	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Hirsutism	hirsutism	NN	NN	_	14	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	graded	grade	VBN	VBN	_	1	acl	_	_
4	by	by	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	modified	modify	VBN	VBN	_	8	amod	_	_
7	Ferriman-Gallwey	ferriman-gallwey	JJ	JJ	_	8	amod	_	_
8	score	score	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	hormonal	hormonal	JJ	JJ	_	12	amod	_	_
12	parameters	parameter	NNS	NNS	_	1	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	evaluated	evaluate	VBN	VBN	_	0	root	_	_
15	basally	basally	RB	RB	_	16	advmod	_	_
16	and	and	CC	CC	_	14	advmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	4-month	4-month	JJ	JJ	_	19	amod	_	_
19	intervals	interval	NNS	NNS	_	16	conj	_	_
20	during	during	IN	IN	_	21	case	_	_
21	treatment	treatment	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	Gonadotropin-releasing	gonadotropin-releasing	JJ	JJ	_	2	amod	_	_
2	hormone	hormone	NN	NN	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	ACTH	acth	NN	NN	_	5	compound	_	_
5	stimulation	stimulation	NN	NN	_	2	conj	_	_
6	tests	test	NNS	NNS	_	2	dep	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	performed	perform	VBN	VBN	_	0	root	_	_
9	before	before	IN	IN	_	15	nmod	_	_
10	and	and	CC	CC	_	15	cc	_	_
11	after	after	IN	IN	_	15	conj	_	_
12	3	3	CD	CD	_	14	compound	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	4	4	CD	CD	_	15	nummod	_	_
15	months	month	NNS	NNS	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	therapy	therapy	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	concentration	concentration	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	androgen	androgen	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	measured	measure	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	in	in	IN	IN	_	18	case	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	the	the	DT	DT	_	18	dep	_	_
18	follicular	follicular	JJ	JJ	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	luteal	luteal	JJ	JJ	_	18	conj	_	_
21	phases	phase	NNS	NNS	_	18	dep	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	menstrual	menstrual	JJ	JJ	_	25	amod	_	_
25	cycle	cycle	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	13	punct	_	_
27	basally	basally	RB	RB	_	28	advmod	_	_
28	and	and	CC	CC	_	13	advmod	_	_
29	after	after	IN	IN	_	31	case	_	_
30	4	4	CD	CD	_	31	nummod	_	_
31	months	month	NNS	NNS	_	28	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	flutamide	flutamide	NN	NN	_	34	compound	_	_
34	treatment	treatment	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Flutamide	flutamide	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	well	well	RB	RB	_	6	advmod	_	_
6	tolerated	tolerate	VBN	VBN	_	1	dep	_	_
7	in	in	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	women	woman	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	with	with	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	noticeable	noticeable	JJ	JJ	_	14	amod	_	_
14	exception	exception	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	one	one	CD	CD	_	17	nummod	_	_
17	patient	patient	NN	NN	_	14	nmod	_	_
18	who	who	WP	WP	_	19	nsubj	_	_
19	presented	present	VBD	VBD	_	17	acl:relcl	_	_
20	increased	increase	VBN	VBN	_	22	amod	_	_
21	serum	serum	NN	NN	_	22	compound	_	_
22	transaminase	transaminase	NN	NN	_	19	dobj	_	_
23	after	after	IN	IN	_	25	case	_	_
24	8	8	CD	CD	_	25	nummod	_	_
25	months	month	NNS	NNS	_	19	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	therapy	therapy	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	Hirsutism	hirsutism	NN	NN	_	3	nsubj	_	_
2	markedly	markedly	RB	RB	_	3	advmod	_	_
3	improved	improve	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	all	all	DT	DT	_	6	det	_	_
6	women	woman	NNS	NNS	_	3	nmod	_	_
7	during	during	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	treatment	treatment	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	Ferriman-Gallwey	ferriman-gallwey	JJ	JJ	_	12	amod	_	_
12	score	score	NN	NN	_	9	dep	_	_
13	after	after	IN	IN	_	15	case	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	year	year	NN	NN	_	12	nmod	_	_
16	:	:	:	:	_	12	punct	_	_
17	4.1	4.1	CD	CD	_	12	dep	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	0.5	0.5	CD	CD	_	17	conj	_	_
20	versus	versus	CC	CC	_	17	cc	_	_
21	14.1	14.1	CD	CD	_	17	conj	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	0.9	0.9	CD	CD	_	21	conj	_	_
24	)	)	-RRB-	-RRB-	_	12	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	serum	serum	NN	NN	_	5	compound	_	_
5	androgens	androgen	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	whereas	whereas	IN	IN	_	13	mark	_	_
10	no	no	DT	DT	_	11	neg	_	_
11	change	change	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	7	advcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	either	either	CC	CC	_	16	cc:preconj	_	_
16	basal	basal	JJ	JJ	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	GnRH-stimulated	gnrh-stimulated	JJ	JJ	_	16	conj	_	_
19	gonadotropins	gonadotropin	NNS	NNS	_	16	dep	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	cortisol	cortisol	NN	NN	_	16	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	17	17	CD	CD	_	26	nummod	_	_
26	alpha-hydroxyprogesterone	alpha-hydroxyprogesterone	NN	NN	_	23	conj	_	_
27	response	response	NN	NN	_	23	dep	_	_
28	to	to	TO	TO	_	29	case	_	_
29	ACTH	acth	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Cycles	cycle	NNS	NNS	_	2	nsubj	_	_
2	remained	remain	VBD	VBD	_	0	root	_	_
3	ovulatory	ovulatory	JJ	JJ	_	2	xcomp	_	_
4	.	.	.	.	_	2	punct	_	_

1	Before	before	IN	IN	_	2	case	_	_
2	treatment	treatment	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	number	number	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	androgen	androgen	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	higher	higher	JJR	JJR	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	luteal	luteal	NN	NN	_	10	nmod	_	_
14	than	than	IN	IN	_	18	case	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	follicular	follicular	JJ	JJ	_	18	amod	_	_
18	phase	phase	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	rhythmic	rhythmic	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
4	disappeared	disappear	VBD	VBD	_	0	root	_	_
5	after	after	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	patients	patient	NNS	NNS	_	10	nsubjpass	_	_
8	had	have	VBD	VBD	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	given	give	VBN	VBN	_	4	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	antiandrogen	antiandrogen	JJ	JJ	_	13	amod	_	_
13	drug	drug	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Flutamide	flutamide	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	effective	effective	JJ	JJ	_	1	dep	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	treatment	treatment	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	hirsutism	hirsutism	NN	NN	_	8	nmod	_	_
11	but	but	CC	CC	_	5	cc	_	_
12	requires	require	VBZ	VBZ	_	5	conj	_	_
13	constant	constant	JJ	JJ	_	14	amod	_	_
14	surveillance	surveillance	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	liver	liver	NN	NN	_	17	compound	_	_
17	function	function	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Androgen	androgen	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	blockade	blockade	NN	NN	_	6	nsubjpass	_	_
4	might	might	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	potentiated	potentiate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	reduction	reduction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	serum	serum	NN	NN	_	12	compound	_	_
12	androgens	androgen	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Flutamide	flutamide	NN	NN	_	2	nsubj	_	_
2	affects	affect	VBZ	VBZ	_	0	root	_	_
3	androgen	androgen	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	behavior	behavior	NN	NN	_	2	dobj	_	_
6	during	during	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	menstrual	menstrual	JJ	JJ	_	9	amod	_	_
9	cycle	cycle	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	meaning	meaning	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	finding	finding	NN	NN	_	2	nmod	_	_
6	remains	remain	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	elucidated	elucidate	VBN	VBN	_	6	xcomp	_	_
10	.	.	.	.	_	6	punct	_	_

1	Cellular	cellular	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	molecular	molecular	JJ	JJ	_	1	conj	_	_
4	mechanisms	mechanism	NNS	NNS	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	1	nmod	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-2	il-2	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-12	il-12	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	NK	nk	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	8	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	an	a	DT	DT	_	9	det	_	_
7	important	important	JJ	JJ	_	9	amod	_	_
8	immunoregulatory	immunoregulatory	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	0	root	_	_
10	produced	produce	VBN	VBN	_	9	acl	_	_
11	predominantly	predominantly	RB	RB	_	10	advmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	large	large	JJ	JJ	_	18	amod	_	_
17	granular	granular	JJ	JJ	_	18	amod	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	14	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	LGL	lgl	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	response	response	NN	NN	_	10	nmod	_	_
24	to	to	TO	TO	_	27	case	_	_
25	different	different	JJ	JJ	_	27	amod	_	_
26	extracellular	extracellular	JJ	JJ	_	27	amod	_	_
27	signals	signal	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	interleukins	interleukin	NNS	NNS	_	16	nsubjpass	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ILs	il	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	IL-2	il-2	NN	NN	_	5	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-12	il-12	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	have	have	VBP	VBP	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	shown	show	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	20	mark	_	_
18	be	be	VB	VB	_	20	cop	_	_
19	potent	potent	JJ	JJ	_	20	amod	_	_
20	inducers	inducer	NNS	NNS	_	16	xcomp	_	_
21	of	of	IN	IN	_	24	case	_	_
22	IFN-gamma	ifn-gamma	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	both	both	CC	CC	_	28	cc:preconj	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	20	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	LGL	lgl	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	16	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	it	it	PRP	PRP	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	reported	report	VBN	VBN	_	30	advcl	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	are	be	VBP	VBP	_	5	ccomp	_	_
9	some	some	DT	DT	_	12	det	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	8	nsubj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	produce	produce	VBP	VBP	_	12	acl:relcl	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	14	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	IL-2	il-2	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-12	il-12	NN	NN	_	19	conj	_	_
22	stimulation	stimulation	NN	NN	_	19	dep	_	_
23	,	,	,	,	_	30	punct	_	_
24	there	there	EX	EX	_	30	expl	_	_
25	has	have	VBZ	VBZ	_	30	aux	_	_
26	as	as	RB	RB	_	27	advmod	_	_
27	yet	yet	RB	RB	_	30	advmod	_	_
28	been	be	VBN	VBN	_	30	cop	_	_
29	no	no	DT	DT	_	30	neg	_	_
30	report	report	NN	NN	_	0	root	_	_
31	of	of	IN	IN	_	39	case	_	_
32	a	a	DT	DT	_	39	det	_	_
33	natural	natural	JJ	JJ	_	39	amod	_	_
34	killer	killer	NN	NN	_	39	compound	_	_
35	(	(	-LRB-	-LRB-	_	39	punct	_	_
36	NK	nk	NN	NN	_	39	compound	_	_
37	)	)	-RRB-	-RRB-	_	39	punct	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	30	nmod	_	_
40	that	that	WDT	WDT	_	41	nsubj	_	_
41	responds	respond	VBZ	VBZ	_	39	acl:relcl	_	_
42	in	in	IN	IN	_	45	case	_	_
43	a	a	DT	DT	_	45	det	_	_
44	similar	similar	JJ	JJ	_	45	amod	_	_
45	manner	manner	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	30	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	present	present	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	line	line	NN	NN	_	11	compound	_	_
11	NK3.3	nk3.3	NN	NN	_	18	nsubj	_	_
12	derived	derive	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	NK	nk	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	responds	respond	VBZ	VBZ	_	6	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	IL-2	il-2	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-12	il-12	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	5	punct	_	_
25	as	as	IN	IN	_	26	mark	_	_
26	measured	measure	VBN	VBN	_	5	advcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	increases	increase	NNS	NNS	_	26	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	IFN-gamma	ifn-gamma	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	34	amod	_	_
33	colony-stimulating	colony-stimulating	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	30	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	GM-CSF	gm-csf	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	cytoplasmic	cytoplasmic	JJ	JJ	_	39	amod	_	_
39	mRNA	mrna	NN	NN	_	30	dep	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	protein	protein	NN	NN	_	42	compound	_	_
42	expression	expression	NN	NN	_	39	conj	_	_
43	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	when	when	WRB	WRB	_	5	advmod	_	_
5	used	use	VBN	VBN	_	10	advcl	_	_
6	together	together	RB	RB	_	5	advmod	_	_
7	IL-2	il-2	NN	NN	_	10	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-12	il-12	NN	NN	_	7	conj	_	_
10	synergized	synergize	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	induction	induction	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	GM-CSF	gm-csf	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	this	this	DT	DT	_	20	det	_	_
20	synergy	synergy	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	attributed	attribute	VBN	VBN	_	10	conj	_	_
23	to	to	TO	TO	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	increased	increase	VBN	VBN	_	26	amod	_	_
26	accumulation	accumulation	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	stability	stability	NN	NN	_	26	conj	_	_
29	of	of	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	IFN-gamma	ifn-gamma	NN	NN	_	34	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	GM-CSF	gm-csf	NN	NN	_	31	conj	_	_
34	mRNAs	mrna	NNS	NNS	_	26	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	2	dobj	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	five	five	CD	CD	_	13	nummod	_	_
13	inhibitors	inhibitor	NNS	NNS	_	34	nsubjpass	_	_
14	,	,	,	,	_	13	punct	_	_
15	cyclosporin	cyclosporin	NN	NN	_	16	compound	_	_
16	A	a	NN	NN	_	13	appos	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CsA	csa	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	16	punct	_	_
21	transforming	transform	VBG	VBG	_	23	amod	_	_
22	growth	growth	NN	NN	_	23	compound	_	_
23	factor-beta	factor-beta	NN	NN	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	cycloheximide	cycloheximide	NN	NN	_	16	conj	_	_
26	,	,	,	,	_	16	punct	_	_
27	genistein	genistein	NN	NN	_	16	conj	_	_
28	,	,	,	,	_	16	punct	_	_
29	and	and	CC	CC	_	16	cc	_	_
30	staurosporine	staurosporine	NN	NN	_	31	compound	_	_
31	A	a	NN	NN	_	16	conj	_	_
32	,	,	,	,	_	13	punct	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	used	use	VBN	VBN	_	2	parataxis	_	_
35	in	in	IN	IN	_	36	mark	_	_
36	analyzing	analyze	VBG	VBG	_	34	advcl	_	_
37	the	the	DT	DT	_	38	det	_	_
38	effects	effect	NNS	NNS	_	36	dobj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	IL-2	il-2	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	IL-12	il-12	NN	NN	_	40	conj	_	_
43	on	on	IN	IN	_	45	case	_	_
44	NK3.3	nk3.3	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	38	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	activation	activation	NN	NN	_	18	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	C	c	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	5	cc	_	_
13	new	new	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	synthesis	synthesis	NN	NN	_	5	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	3	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	induction	induction	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	GM-CSF	gm-csf	NN	NN	_	23	conj	_	_
26	cytoplasmic	cytoplasmic	JJ	JJ	_	27	amod	_	_
27	mRNA	mrna	NN	NN	_	23	dep	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	IL-12	il-12	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	9	compound	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	9	amod	_	_
9	mRNA	mrna	NN	NN	_	5	nmod	_	_
10	appears	appear	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	14	mark	_	_
12	only	only	RB	RB	_	13	advmod	_	_
13	partially	partially	RB	RB	_	14	advmod	_	_
14	depend	depend	VB	VB	_	10	xcomp	_	_
15	on	on	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	C	c	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	both	both	CC	CC	_	6	cc:preconj	_	_
4	transforming	transform	VBG	VBG	_	6	amod	_	_
5	growth	growth	NN	NN	_	6	compound	_	_
6	factor-beta	factor-beta	NN	NN	_	16	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	genistein	genistein	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	8	appos	_	_
14	,	,	,	,	_	6	punct	_	_
15	could	could	MD	MD	_	16	aux	_	_
16	suppress	suppress	VB	VB	_	0	root	_	_
17	IL-2	il-2	NN	NN	_	16	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-12	il-12	NN	NN	_	17	conj	_	_
20	signaling	signaling	NN	NN	_	17	dep	_	_
21	but	but	CC	CC	_	16	cc	_	_
22	CsA	csa	NN	NN	_	25	nsubj	_	_
23	was	be	VBD	VBD	_	25	cop	_	_
24	generally	generally	RB	RB	_	25	advmod	_	_
25	inactive	inactive	JJ	JJ	_	16	conj	_	_
26	.	.	.	.	_	16	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	also	also	RB	RB	_	4	advmod	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	suppression	suppression	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	cytokine	cytokine	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	agents	agent	NNS	NNS	_	6	nmod	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	independent	independent	JJ	JJ	_	4	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	inhibition	inhibition	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	proliferation	proliferation	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	IL-2	il-2	NN	NN	_	8	nsubj	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	4	cc	_	_
7	IL-12	il-12	NN	NN	_	4	conj	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	8	dobj	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	AP1	ap1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	regulation	regulation	NN	NN	_	30	nsubjpass	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	17	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	these	these	DT	DT	_	28	det	_	_
24	two	two	CD	CD	_	28	nummod	_	_
25	DNA	dna	NN	NN	_	28	compound	_	_
26	binding	binding	NN	NN	_	28	compound	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	complexes	complex	NNS	NNS	_	21	nmod	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	correlated	correlate	VBN	VBN	_	8	conj	_	_
31	with	with	IN	IN	_	32	case	_	_
32	IFN-gamma	ifn-gamma	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	GM-CSF	gm-csf	NN	NN	_	32	conj	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	32	dep	_	_
37	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	IL-2	il-2	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-12	il-12	NN	NN	_	5	conj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	have	have	VB	VB	_	3	ccomp	_	_
10	distinct	distinct	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	9	dobj	_	_
13	leading	lead	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	GM-CSF	gm-csf	NN	NN	_	18	conj	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	dep	_	_
23	,	,	,	,	_	9	punct	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	the	the	DT	DT	_	29	det	_	_
27	NK3.3	nk3.3	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	31	nsubj	_	_
30	may	may	MD	MD	_	31	aux	_	_
31	serve	serve	VB	VB	_	9	conj	_	_
32	as	as	IN	IN	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	novel	novel	JJ	JJ	_	35	amod	_	_
35	model	model	NN	NN	_	31	nmod	_	_
36	for	for	IN	IN	_	37	mark	_	_
37	dissecting	dissect	VBG	VBG	_	35	acl	_	_
38	the	the	DT	DT	_	39	dep	_	_
39	biochemical	biochemical	JJ	JJ	_	37	dobj	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	molecular	molecular	JJ	JJ	_	39	conj	_	_
42	events	event	NNS	NNS	_	39	dep	_	_
43	involved	involve	VBN	VBN	_	39	acl	_	_
44	in	in	IN	IN	_	46	case	_	_
45	these	these	DT	DT	_	46	det	_	_
46	pathways	pathway	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	3	punct	_	_

1	Interleukin	interleukin	NN	NN	_	3	compound	_	_
2	2	2	CD	CD	_	3	nummod	_	_
3	signaling	signaling	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Stat	stat	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	immune	immune	JJ	JJ	_	11	amod	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	regulation	regulation	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	interleukin	interleukin	NN	NN	_	0	root	_	_
14	2	2	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-2	il-2	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	13	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	potent	potent	JJ	JJ	_	21	amod	_	_
21	activator	activator	NN	NN	_	13	appos	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	proliferation	proliferation	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	function	function	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	natural	natural	JJ	JJ	_	33	amod	_	_
32	killer	killer	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	15	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	10	nmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-2	il-2	NN	NN	_	6	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	propagated	propagate	VBN	VBN	_	2	acl:relcl	_	_
11	within	within	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	understood	understand	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	While	while	IN	IN	_	11	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	binding	binding	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	receptor	receptor	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	recently	recently	RB	RB	_	11	advmod	_	_
11	shown	show	VBN	VBN	_	45	advcl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	lead	lead	VB	VB	_	11	xcomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	kinases	kinase	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	Jak-1	jak-1	NN	NN	_	19	appos	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Jak-3	jak-3	CD	CD	_	21	conj	_	_
24	,	,	,	,	_	45	punct	_	_
25	subsequent	subsequent	JJ	JJ	_	26	amod	_	_
26	steps	step	NNS	NNS	_	45	nsubjpass	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	signaling	signaling	NN	NN	_	30	compound	_	_
30	pathway	pathway	NN	NN	_	26	nmod	_	_
31	to	to	TO	TO	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	nucleus	nucleus	NN	NN	_	30	nmod	_	_
34	that	that	WDT	WDT	_	35	nsubj	_	_
35	lead	lead	VBP	VBP	_	26	acl:relcl	_	_
36	to	to	TO	TO	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	activation	activation	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	specific	specific	JJ	JJ	_	41	amod	_	_
41	genes	gene	NNS	NNS	_	38	nmod	_	_
42	had	have	VBD	VBD	_	45	aux	_	_
43	not	not	RB	RB	_	45	neg	_	_
44	been	be	VBN	VBN	_	45	auxpass	_	_
45	characterized	characterize	VBN	VBN	_	0	root	_	_
46	.	.	.	.	_	45	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	many	many	JJ	JJ	_	3	amod	_	_
3	cytokines	cytokine	NNS	NNS	_	9	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	activate	activate	VBP	VBP	_	3	acl:relcl	_	_
6	Jak	jak	NN	NN	_	7	compound	_	_
7	kinases	kinase	NNS	NNS	_	5	dobj	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	lead	lead	VBP	VBP	_	35	advcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	dep	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	activation	activation	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	members	member	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Stat	stat	NN	NN	_	21	compound	_	_
21	family	family	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	35	punct	_	_
26	the	the	DT	DT	_	27	det	_	_
27	ability	ability	NN	NN	_	35	nsubjpass	_	_
28	of	of	IN	IN	_	29	case	_	_
29	IL-2	il-2	NN	NN	_	27	nmod	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	trigger	trigger	VB	VB	_	27	acl	_	_
32	Stat	stat	NN	NN	_	33	compound	_	_
33	phosphorylation	phosphorylation	NN	NN	_	31	dobj	_	_
34	was	be	VBD	VBD	_	35	auxpass	_	_
35	examined	examine	VBN	VBN	_	0	root	_	_
36	.	.	.	.	_	35	punct	_	_

1	Exposure	exposure	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	activated	activate	VBN	VBN	_	6	amod	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	of	of	IN	IN	_	13	case	_	_
9	a	a	DT	DT	_	13	det	_	_
10	natural	natural	JJ	JJ	_	13	amod	_	_
11	killer	killer	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	6	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NKL	nkl	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	to	to	TO	TO	_	18	case	_	_
18	IL-2	il-2	NN	NN	_	1	nmod	_	_
19	leads	lead	VBZ	VBZ	_	0	root	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	phosphorylation	phosphorylation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Stat1	stat1	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	Stat1	stat1	NN	NN	_	28	compound	_	_
28	beta	beta	NN	NN	_	25	conj	_	_
29	,	,	,	,	_	25	punct	_	_
30	and	and	CC	CC	_	25	cc	_	_
31	Stat3	stat3	NN	NN	_	25	conj	_	_
32	,	,	,	,	_	25	punct	_	_
33	as	as	RB	RB	_	25	cc	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	as	as	IN	IN	_	33	mwe	_	_
36	of	of	IN	IN	_	39	case	_	_
37	two	two	CD	CD	_	39	nummod	_	_
38	Stat-related	stat-related	JJ	JJ	_	39	amod	_	_
39	proteins	protein	NNS	NNS	_	25	conj	_	_
40	,	,	,	,	_	39	punct	_	_
41	p94	p94	NN	NN	_	39	appos	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	p95	p95	NN	NN	_	41	conj	_	_
44	.	.	.	.	_	19	punct	_	_

1	p94	p94	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p95	p95	NN	NN	_	1	conj	_	_
4	share	share	VBP	VBP	_	0	root	_	_
5	homology	homology	NN	NN	_	4	dobj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	Stat1	stat1	NN	NN	_	4	nmod	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	phosphorylation	phosphorylation	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	4	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	in	in	IN	IN	_	21	case	_	_
14	the	the	DT	DT	_	21	det	_	_
15	Src	src	NN	NN	_	21	compound	_	_
16	homology	homology	NN	NN	_	21	compound	_	_
17	2	2	CD	CD	_	21	nummod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	SH2	sh2	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	domain	domain	NN	NN	_	11	conj	_	_
22	,	,	,	,	_	4	punct	_	_
23	but	but	CC	CC	_	4	cc	_	_
24	otherwise	otherwise	RB	RB	_	27	advmod	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	immunologically	immunologically	RB	RB	_	27	advmod	_	_
27	distinct	distinct	JJ	JJ	_	4	conj	_	_
28	from	from	IN	IN	_	29	case	_	_
29	Stat1	stat1	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	Stat	stat	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	translocate	translocate	VB	VB	_	5	ccomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	bind	bind	VB	VB	_	7	conj	_	_
14	to	to	TO	TO	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	14	nmod	_	_
8	IL-2	il-2	NN	NN	_	14	nsubj	_	_
9	binding	bind	VBG	VBG	_	8	acl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	receptor	receptor	NN	NN	_	9	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	activate	activate	VB	VB	_	5	acl:relcl	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	14	dobj	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	21	case	_	_
19	immune	immune	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	erythroid-specific	erythroid-specific	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	megakaryoblastic	megakaryoblastic	JJ	JJ	_	8	amod	_	_
8	leukaemia	leukaemia	NN	NN	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	transient	transient	JJ	JJ	_	12	amod	_	_
11	myeloproliferative	myeloproliferative	JJ	JJ	_	12	amod	_	_
12	disorder	disorder	NN	NN	_	8	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Down	down	NN	NN	_	16	nmod:poss	_	_
15	's	's	POS	POS	_	16	case	_	_
16	syndrome	syndrome	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	megakaryoblastic	megakaryoblastic	JJ	JJ	_	3	amod	_	_
3	leukaemia	leukaemia	NN	NN	_	19	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	M7	m7	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	transient	transient	JJ	JJ	_	10	amod	_	_
9	myeloproliferative	myeloproliferative	JJ	JJ	_	10	amod	_	_
10	disorder	disorder	NN	NN	_	3	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	Down	down	NN	NN	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	14	case	_	_
14	syndrome	syndrome	NN	NN	_	3	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TMD	tmd	NN	NN	_	3	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	characterized	characterize	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	22	case	_	_
21	rapid	rapid	JJ	JJ	_	22	amod	_	_
22	growth	growth	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	abnormal	abnormal	JJ	JJ	_	26	amod	_	_
25	blast	blast	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	express	express	VBP	VBP	_	26	acl:relcl	_	_
29	megakaryocytic	megakaryocytic	JJ	JJ	_	30	amod	_	_
30	markers	marker	NNS	NNS	_	28	dobj	_	_
31	.	.	.	.	_	19	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	0	root	_	_
3	properties	property	NNS	NNS	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	blast	blast	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	M7	m7	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	TMD	tmd	NN	NN	_	9	conj	_	_
12	cases	case	NNS	NNS	_	9	dep	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	examined	examine	VBD	VBD	_	2	parataxis	_	_
16	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
17	markers	marker	NNS	NNS	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	blasts	blast	NNS	NNS	_	18	nmod	_	_
21	from	from	IN	IN	_	23	case	_	_
22	six	six	CD	CD	_	23	nummod	_	_
23	cases	case	NNS	NNS	_	20	nmod	_	_
24	with	with	IN	IN	_	25	case	_	_
25	M7	m7	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	seven	seven	CD	CD	_	28	nummod	_	_
28	cases	case	NNS	NNS	_	23	conj	_	_
29	with	with	IN	IN	_	30	case	_	_
30	TMD	tmd	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	study	study	NN	NN	_	15	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Erythroid-specific	erythroid-specific	JJ	JJ	_	2	amod	_	_
2	mRNAs	mrna	NNS	NNS	_	10	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	gamma-globin	gamma-globin	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
7	delta-aminolevulinate	delta-aminolevulinate	JJ	JJ	_	8	amod	_	_
8	synthase	synthase	NN	NN	_	4	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	10	xcomp	_	_
14	in	in	IN	IN	_	15	case	_	_
15	blasts	blast	NNS	NNS	_	13	nmod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	most	most	JJS	JJS	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	cases	case	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	indicating	indicate	VBG	VBG	_	10	advcl	_	_
23	that	that	IN	IN	_	33	mark	_	_
24	majorities	majority	NNS	NNS	_	33	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	blasts	blast	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	M7	m7	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	TMD	tmd	NN	NN	_	29	conj	_	_
32	cases	case	NNS	NNS	_	29	dep	_	_
33	have	have	VBP	VBP	_	22	ccomp	_	_
34	erythroid	erythroid	JJ	JJ	_	33	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	megakaryocytic	megakaryocytic	JJ	JJ	_	34	conj	_	_
37	phenotypes	phenotype	NNS	NNS	_	34	dep	_	_
38	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	mRNAs	mrna	NNS	NNS	_	11	nsubjpass	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	GATA-1	gata-1	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	GATA-2	gata-2	NN	NN	_	7	conj	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	15	case	_	_
13	all	all	DT	DT	_	15	det:predet	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cases	case	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	M7	m7	NN	NN	_	6	compound	_	_
6	blasts	blast	NNS	NNS	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TMD	tmd	NN	NN	_	9	compound	_	_
9	blasts	blast	NNS	NNS	_	6	conj	_	_
10	correspond	correspond	VBP	VBP	_	3	ccomp	_	_
11	to	to	TO	TO	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	erythroid/megakaryocytic	erythroid/megakaryocytic	JJ	JJ	_	16	amod	_	_
14	bipotential	bipotential	JJ	JJ	_	16	amod	_	_
15	progenitor	progenitor	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Relationship	relationship	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	5	case	_	_
3	Rap1	rap1	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	regulation	regulation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Ca2+	ca2+	NN	NN	_	10	compound	_	_
10	transport	transport	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	platelets	platelet	NNS	NNS	_	5	nmod	_	_
13	:	:	:	:	_	1	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	new	new	JJ	JJ	_	16	amod	_	_
16	approach	approach	NN	NN	_	1	dep	_	_
17	.	.	.	.	_	1	punct	_	_

1	Although	although	IN	IN	_	17	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	interrelationship	interrelationship	NN	NN	_	17	nsubjpass	_	_
4	between	between	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	messengers	messenger	NNS	NNS	_	3	nmod	_	_
8	Ca2+	ca2+	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	cyclic	cyclic	JJ	JJ	_	11	amod	_	_
11	AMP	amp	NN	NN	_	8	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	platelet	platelet	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	3	nmod	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	well	well	RB	RB	_	17	advmod	_	_
17	documented	document	VBN	VBN	_	24	advcl	_	_
18	,	,	,	,	_	24	punct	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	mechanism	mechanism	NN	NN	_	24	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	action	action	NN	NN	_	20	nmod	_	_
23	still	still	RB	RB	_	24	advmod	_	_
24	remains	remain	VBZ	VBZ	_	0	root	_	_
25	to	to	TO	TO	_	27	mark	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	established	establish	VBN	VBN	_	24	xcomp	_	_
28	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	question	question	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	platelet	platelet	NN	NN	_	11	compound	_	_
11	Ca(2+)-ATPases	ca(2+)-atpase	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	cyclic	cyclic	JJ	JJ	_	14	amod	_	_
14	AMP	amp	NN	NN	_	8	nmod	_	_
15	through	through	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phosphorylation	phosphorylation	NN	NN	_	8	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Rap1	rap1	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	nmod	_	_
22	using	use	VBG	VBG	_	2	xcomp	_	_
23	a	a	DT	DT	_	25	det	_	_
24	pathological	pathological	JJ	JJ	_	25	amod	_	_
25	model	model	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	first	first	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	experimental	experimental	JJ	JJ	_	5	amod	_	_
5	conditions	condition	NNS	NNS	_	3	dobj	_	_
6	where	where	WRB	WRB	_	12	advmod	_	_
7	Ca(2+)-transport	ca(2+)-transport	NN	NN	_	12	nsubj	_	_
8	by	by	IN	IN	_	11	case	_	_
9	platelet	platelet	NN	NN	_	11	compound	_	_
10	membrane	membrane	NN	NN	_	11	compound	_	_
11	vesicles	vesicle	NNS	NNS	_	7	nmod	_	_
12	appeared	appear	VBD	VBD	_	5	acl:relcl	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	12	xcomp	_	_
16	on	on	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	Rap1	rap1	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Then	then	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	platelets	platelet	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	congestive	congestive	JJ	JJ	_	11	amod	_	_
10	heart	heart	NN	NN	_	11	compound	_	_
11	failure	failure	NN	NN	_	7	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	expression	expression	NN	NN	_	4	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	potential	potential	JJ	JJ	_	21	amod	_	_
18	97	97	CD	CD	_	21	nummod	_	_
19	kDa	kda	NN	NN	_	21	compound	_	_
20	Ca(2+)-ATPase	ca(2+)-atpase	NN	NN	_	21	compound	_	_
21	target	target	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	regulation	regulation	NN	NN	_	21	nmod	_	_
24	through	through	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	Rap1	rap1	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	4	nmod	_	_
28	as	as	RB	RB	_	27	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	the	the	DT	DT	_	32	det	_	_
32	phosphorylation	phosphorylation	NN	NN	_	27	conj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	Rap1	rap1	NN	NN	_	36	compound	_	_
36	protein	protein	NN	NN	_	32	nmod	_	_
37	using	use	VBG	VBG	_	4	xcomp	_	_
38	the	the	DT	DT	_	40	det	_	_
39	catalytic	catalytic	JJ	JJ	_	40	amod	_	_
40	subunit	subunit	NN	NN	_	37	dobj	_	_
41	of	of	IN	IN	_	46	case	_	_
42	the	the	DT	DT	_	46	det	_	_
43	cyclic	cyclic	JJ	JJ	_	46	amod	_	_
44	AMP-dependent	amp-dependent	JJ	JJ	_	46	amod	_	_
45	protein	protein	NN	NN	_	46	compound	_	_
46	kinase	kinase	NN	NN	_	40	nmod	_	_
47	(	(	-LRB-	-LRB-	_	49	punct	_	_
48	C.	c.	JJ	JJ	_	49	amod	_	_
49	Sub.	sub.	NN	NN	_	40	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	patients	patient	NNS	NNS	_	8	nmod	_	_
5	studied	study	VBN	VBN	_	4	acl	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	found	find	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	11	neg	_	_
10	significant	significant	JJ	JJ	_	11	amod	_	_
11	modification	modification	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	97	97	CD	CD	_	19	nummod	_	_
18	kDa	kda	NN	NN	_	19	compound	_	_
19	Ca(2+)-ATPase	ca(2+)-atpase	NN	NN	_	14	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	Western	western	NN	NN	_	22	compound	_	_
22	blotting	blotting	NN	NN	_	8	nmod	_	_
23	using	use	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	28	det	_	_
25	PL/IM	pl/im	NN	NN	_	28	compound	_	_
26	430	430	CD	CD	_	28	nummod	_	_
27	monoclonal	monoclonal	JJ	JJ	_	28	amod	_	_
28	antibody	antibody	NN	NN	_	23	dobj	_	_
29	which	which	WDT	WDT	_	31	nsubj	_	_
30	specifically	specifically	RB	RB	_	31	advmod	_	_
31	recognized	recognize	VBD	VBD	_	28	acl:relcl	_	_
32	this	this	DT	DT	_	33	det	_	_
33	isoform	isoform	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Rap1	rap1	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	differentially	differentially	RB	RB	_	9	advmod	_	_
9	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	11	advmod	_	_
11	using	use	VBG	VBG	_	9	advcl	_	_
12	15	15	CD	CD	_	13	nummod	_	_
13	micrograms/ml	micrograms/ml	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	C.	c.	NN	NN	_	17	compound	_	_
17	Sub	sub	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	allowed	allow	VBD	VBD	_	0	root	_	_
4	us	we	PRP	PRP	_	3	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	use	use	VB	VB	_	3	xcomp	_	_
7	these	these	DT	DT	_	9	det	_	_
8	pathological	pathological	JJ	JJ	_	9	amod	_	_
9	platelets	platelet	NNS	NNS	_	6	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	study	study	VB	VB	_	6	xcomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	relationship	relationship	NN	NN	_	11	dobj	_	_
14	between	between	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	Rap1	rap1	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	regulation	regulation	NN	NN	_	16	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Ca2+	ca2+	NN	NN	_	25	compound	_	_
25	transport	transport	NN	NN	_	22	nmod	_	_
26	by	by	IN	IN	_	27	mark	_	_
27	selecting	select	VBG	VBG	_	11	advcl	_	_
28	a	a	DT	DT	_	29	det	_	_
29	patient	patient	NN	NN	_	27	dobj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	severe	severe	JJ	JJ	_	33	amod	_	_
32	heart	heart	NN	NN	_	33	compound	_	_
33	failure	failure	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	could	could	MD	MD	_	3	aux	_	_
3	show	show	VB	VB	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	decrease	decrease	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	as	as	RB	RB	_	8	cc	_	_
10	well	well	RB	RB	_	9	mwe	_	_
11	as	as	IN	IN	_	9	mwe	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	phosphorylation	phosphorylation	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Rap1	rap1	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	demonstrate	demonstrate	VB	VB	_	3	conj	_	_
20	a	a	DT	DT	_	22	det	_	_
21	lower	lower	JJR	JJR	_	22	amod	_	_
22	effect	effect	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	C.	c.	JJ	JJ	_	25	amod	_	_
25	Sub.	sub.	NN	NN	_	22	nmod	_	_
26	on	on	IN	IN	_	28	case	_	_
27	Ca2+	ca2+	NN	NN	_	28	compound	_	_
28	transport	transport	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	by	by	IN	IN	_	4	mark	_	_
4	studying	study	VBG	VBG	_	13	advcl	_	_
5	a	a	DT	DT	_	7	det	_	_
6	further	further	JJ	JJ	_	7	amod	_	_
7	series	series	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	could	could	MD	MD	_	13	aux	_	_
13	confirm	confirm	VB	VB	_	0	root	_	_
14	that	that	IN	IN	_	30	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	decrease	decrease	NN	NN	_	30	nsubj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	Rap1	rap1	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	heart	heart	NN	NN	_	23	compound	_	_
23	failure	failure	NN	NN	_	16	nmod	_	_
24	,	,	,	,	_	16	punct	_	_
25	whatever	whatever	WDT	WDT	_	27	dep	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	extent	extent	NN	NN	_	30	dep	_	_
28	,	,	,	,	_	30	punct	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	variable	variable	JJ	JJ	_	13	ccomp	_	_
31	,	,	,	,	_	13	punct	_	_
32	and	and	CC	CC	_	13	cc	_	_
33	could	could	MD	MD	_	35	aux	_	_
34	strictly	strictly	RB	RB	_	35	advmod	_	_
35	correlate	correlate	VB	VB	_	13	conj	_	_
36	the	the	DT	DT	_	37	det	_	_
37	expression	expression	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	Rap1	rap1	NN	NN	_	40	compound	_	_
40	protein	protein	NN	NN	_	37	nmod	_	_
41	with	with	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	stimulatory	stimulatory	JJ	JJ	_	44	amod	_	_
44	effect	effect	NN	NN	_	35	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	C.	c.	JJ	JJ	_	47	amod	_	_
47	Sub.	sub.	NN	NN	_	44	nmod	_	_
48	on	on	IN	IN	_	50	case	_	_
49	Ca2+	ca2+	NN	NN	_	50	compound	_	_
50	transport	transport	NN	NN	_	44	nmod	_	_
51	.	.	.	.	_	13	punct	_	_

1	Besides	besides	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	evidence	evidence	NN	NN	_	23	nmod	_	_
4	for	for	IN	IN	_	5	case	_	_
5	regulation	regulation	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Rap1	rap1	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	platelets	platelet	NNS	NNS	_	5	nmod	_	_
15	from	from	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	heart	heart	NN	NN	_	19	compound	_	_
19	failure	failure	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	these	these	DT	DT	_	22	det	_	_
22	findings	finding	NNS	NNS	_	23	nsubj	_	_
23	constitute	constitute	VBP	VBP	_	0	root	_	_
24	a	a	DT	DT	_	26	det	_	_
25	new	new	JJ	JJ	_	26	amod	_	_
26	approach	approach	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	favour	favour	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	regulation	regulation	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	platelet	platelet	NN	NN	_	35	compound	_	_
34	Ca2+	ca2+	NN	NN	_	35	compound	_	_
35	transport	transport	NN	NN	_	31	nmod	_	_
36	through	through	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	phosphorylation	phosphorylation	NN	NN	_	31	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	Rap1	rap1	NN	NN	_	42	compound	_	_
42	protein	protein	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	23	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	NFATp	nfatp	NN	NN	_	5	dep	_	_
7	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
8	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
9	DNA	dna	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	cyclosporin	cyclosporin	NN	NN	_	16	compound	_	_
14	A-treated	a-treated	JJ	JJ	_	16	amod	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	B	b	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CsA	csa	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	exerts	exert	VBZ	VBZ	_	0	root	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	immunosuppressive	immunosuppressive	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	inhibiting	inhibit	VBG	VBG	_	6	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	activated	activate	VBN	VBN	_	16	acl	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	18	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NFAT	nfat	NN	NN	_	16	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	6	punct	_	_
25	thus	thus	RB	RB	_	26	advmod	_	_
26	preventing	prevent	VBG	VBG	_	6	advcl	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	induction	induction	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	several	several	JJ	JJ	_	32	amod	_	_
31	cytokine	cytokine	NN	NN	_	32	compound	_	_
32	genes	gene	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	thought	think	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	auxpass	_	_
7	largely	largely	RB	RB	_	8	advmod	_	_
8	mediated	mediate	VBN	VBN	_	4	xcomp	_	_
9	through	through	IN	IN	_	10	case	_	_
10	inactivation	inactivation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	phosphatase	phosphatase	NN	NN	_	10	nmod	_	_
14	calcineurin	calcineurin	NN	NN	_	13	dep	_	_
15	,	,	,	,	_	10	punct	_	_
16	which	which	WDT	WDT	_	19	nsubj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	turn	turn	NN	NN	_	19	nmod	_	_
19	inhibits	inhibit	VBZ	VBZ	_	10	acl:relcl	_	_
20	translocation	translocation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	an	a	DT	DT	_	24	det	_	_
23	NFAT	nfat	NN	NN	_	24	compound	_	_
24	component	component	NN	NN	_	20	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	nucleus	nucleus	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	CsA	csa	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Raji	raji	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Jurkat	jurkat	NN	NN	_	14	compound	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	9	conj	_	_
15	yields	yield	VBZ	VBZ	_	3	ccomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	phosphorylated	phosphorylated	JJ	JJ	_	18	amod	_	_
18	form	form	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	NFATp	nfatp	NN	NN	_	18	nmod	_	_
21	that	that	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	inhibited	inhibit	VBN	VBN	_	18	acl:relcl	_	_
24	in	in	IN	IN	_	25	case	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	in	in	IN	IN	_	29	case	_	_
28	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
29	ability	ability	NN	NN	_	25	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	form	form	VB	VB	_	29	acl	_	_
32	an	a	DT	DT	_	34	det	_	_
33	NFAT	nfat	NN	NN	_	34	compound	_	_
34	complex	complex	NN	NN	_	31	dobj	_	_
35	with	with	IN	IN	_	36	case	_	_
36	Fos	fos	NN	NN	_	31	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	Jun	jun	NN	NN	_	36	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	Immunoblot	immunoblot	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	metabolic	metabolic	JJ	JJ	_	5	amod	_	_
5	labeling	labeling	NN	NN	_	2	conj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	-LSB-32P-RSB-orthophosphate	-lsb-32p-rsb-orthophosphate	NN	NN	_	5	nmod	_	_
8	show	show	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	CsA	csa	NN	NN	_	11	nsubj	_	_
11	alters	alter	VBZ	VBZ	_	8	ccomp	_	_
12	NFATp	nfatp	NN	NN	_	13	compound	_	_
13	migration	migration	NN	NN	_	11	dobj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	SDS-polyacrylamide	sds-polyacrylamide	NN	NN	_	17	compound	_	_
16	gel	gel	NN	NN	_	17	compound	_	_
17	electrophoresis	electrophoresis	NN	NN	_	13	nmod	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	increasing	increase	VBG	VBG	_	11	advcl	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	phosphorylation	phosphorylation	NN	NN	_	22	compound	_	_
22	level	level	NN	NN	_	19	dobj	_	_
23	without	without	IN	IN	_	24	mark	_	_
24	affecting	affect	VBG	VBG	_	19	advcl	_	_
25	subcellular	subcellular	JJ	JJ	_	26	amod	_	_
26	distribution	distribution	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	8	punct	_	_

1	Dephosphorylation	dephosphorylation	NN	NN	_	11	nsubj	_	_
2	by	by	IN	IN	_	5	case	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	treatment	treatment	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	calcineurin	calcineurin	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	alkaline	alkaline	NN	NN	_	10	compound	_	_
10	phosphatase	phosphatase	NN	NN	_	7	conj	_	_
11	restores	restore	VBZ	VBZ	_	0	root	_	_
12	NFATp	nfatp	NN	NN	_	15	compound	_	_
13	DNA	dna	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	ability	ability	NN	NN	_	15	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	reconstitute	reconstitute	VB	VB	_	18	acl	_	_
21	an	a	DT	DT	_	23	det	_	_
22	NFAT	nfat	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	20	dobj	_	_
24	with	with	IN	IN	_	25	case	_	_
25	Fos	fos	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	Jun	jun	NN	NN	_	25	conj	_	_
28	proteins	protein	NNS	NNS	_	25	dep	_	_
29	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	point	point	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	3	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	CsA-sensitive	csa-sensitive	JJ	JJ	_	10	amod	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFATp	nfatp	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	17	nmod	_	_
15	dephosphorylation	dephosphorylation	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	critical	critical	JJ	JJ	_	12	acl:relcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	Jak	jak	NN	NN	_	7	compound	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	kinases	kinase	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	20	case	_	_
9	human	human	JJ	JJ	_	20	amod	_	_
10	T	t	NN	NN	_	20	compound	_	_
11	cell	cell	NN	NN	_	20	compound	_	_
12	leukemia	leukemia	NN	NN	_	20	compound	_	_
13	virus	virus	NN	NN	_	20	compound	_	_
14	type	type	NN	NN	_	20	compound	_	_
15	1	1	CD	CD	_	20	nummod	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	HTLV-1	htlv-1	NN	NN	_	20	compound	_	_
18	)	)	-RRB-	-RRB-	_	20	punct	_	_
19	tax	tax	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	2	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	virus-transformed	virus-transformed	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	HTLV-1	htlv-1	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	3	nsubj	_	_
3	causes	cause	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	8	det	_	_
5	adult	adult	JJ	JJ	_	8	amod	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	leukemia	leukemia	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	humans	human	NNS	NNS	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	viral	viral	JJ	JJ	_	4	amod	_	_
3	encoded	encode	VBN	VBN	_	4	amod	_	_
4	protein	protein	NN	NN	_	8	nsubjpass	_	_
5	tax	tax	NN	NN	_	4	dep	_	_
6	,	,	,	,	_	4	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	thought	think	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	oncogenesis	oncogenesis	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	11	nsubj	_	_
4	obtained	obtain	VBN	VBN	_	3	acl	_	_
5	from	from	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	tax	tax	NN	NN	_	10	compound	_	_
8	transgenic	transgenic	JJ	JJ	_	10	amod	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	model	model	NN	NN	_	4	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	tax	tax	NN	NN	_	14	nsubj	_	_
14	transforms	transform	VBZ	VBZ	_	11	ccomp	_	_
15	mouse	mouse	NN	NN	_	16	compound	_	_
16	fibroblasts	fibroblast	NNS	NNS	_	14	dobj	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	thymocytes	thymocyte	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	despite	despite	IN	IN	_	23	case	_	_
22	comparable	comparable	JJ	JJ	_	23	amod	_	_
23	levels	level	NNS	NNS	_	14	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	tax	tax	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	both	both	DT	DT	_	29	det	_	_
29	tissues	tissue	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	130-kD	130-kd	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	s	s	NNS	NNS	_	3	nmod	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	tax	tax	NN	NN	_	12	nmod	_	_
16	transformed	transformed	JJ	JJ	_	19	amod	_	_
17	fibroblast	fibroblast	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	15	dep	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	in	in	IN	IN	_	26	case	_	_
22	HTLV-1	htlv-1	NN	NN	_	26	compound	_	_
23	transformed	transformed	JJ	JJ	_	26	amod	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
26	lines	line	NNS	NNS	_	15	conj	_	_
27	,	,	,	,	_	15	punct	_	_
28	but	but	CC	CC	_	15	cc	_	_
29	not	not	RB	RB	_	31	neg	_	_
30	in	in	IN	IN	_	31	case	_	_
31	thymocytes	thymocyte	NNS	NNS	_	15	conj	_	_
32	from	from	IN	IN	_	35	case	_	_
33	Thy-tax	thy-tax	NN	NN	_	35	compound	_	_
34	transgenic	transgenic	JJ	JJ	_	35	amod	_	_
35	mice	mouse	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	12	punct	_	_

1	Phosphotyrosine	phosphotyrosine	NN	NN	_	2	compound	_	_
2	immunoprecipitation	immunoprecipitation	NN	NN	_	17	nsubj	_	_
3	followed	follow	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	7	case	_	_
5	Western	western	NN	NN	_	7	compound	_	_
6	blot	blot	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	set	set	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	Jak	jak	NN	NN	_	15	compound	_	_
13	kinase	kinase	NN	NN	_	15	compound	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	antibodies	antibody	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	identified	identify	VBD	VBD	_	0	root	_	_
18	p130	p130	NN	NN	_	17	dobj	_	_
19	as	as	IN	IN	_	20	case	_	_
20	Jak2	jak2	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	tax	tax	NN	NN	_	20	nmod	_	_
24	transformed	transformed	JJ	JJ	_	23	amod	_	_
25	mouse	mouse	NN	NN	_	28	compound	_	_
26	fibroblastic	fibroblastic	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	23	dep	_	_
29	and	and	CC	CC	_	20	cc	_	_
30	Jak3	jak3	NN	NN	_	20	conj	_	_
31	in	in	IN	IN	_	37	case	_	_
32	HTLV-1	htlv-1	NN	NN	_	37	compound	_	_
33	transformed	transformed	JJ	JJ	_	37	amod	_	_
34	human	human	JJ	JJ	_	37	amod	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	20	nmod	_	_
38	.	.	.	.	_	17	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Jak2	jak2	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	tax	tax	NN	NN	_	7	compound	_	_
6	transformed	transformed	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	from	from	IN	IN	_	11	case	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-6	il-6	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	could	could	MD	MD	_	9	aux	_	_
7	also	also	RB	RB	_	9	advmod	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Balb/c3T3	balb/c3t3	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	using	use	VBG	VBG	_	9	xcomp	_	_
14	a	a	DT	DT	_	15	det	_	_
15	supernatant	supernatant	NN	NN	_	13	dobj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	associated	associate	VBN	VBN	_	15	acl:relcl	_	_
24	with	with	IN	IN	_	25	case	_	_
25	induction	induction	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	proliferation	proliferation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	phosphorylation	phosphorylation	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	proliferation	proliferation	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	inhibited	inhibit	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	IL-6	il-6	NN	NN	_	10	compound	_	_
9	neutralizing	neutralizing	NN	NN	_	10	compound	_	_
10	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	phosphorylation	phosphorylation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Jak	jak	NN	NN	_	5	compound	_	_
5	kinases	kinase	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	facilitate	facilitate	VB	VB	_	0	root	_	_
8	tumor	tumor	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	16	case	_	_
11	both	both	CC	CC	_	16	cc:preconj	_	_
12	HTLV-1	htlv-1	NN	NN	_	16	compound	_	_
13	infected	infected	JJ	JJ	_	16	amod	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transgenic	transgenic	JJ	JJ	_	21	amod	_	_
20	mouse	mouse	NN	NN	_	21	compound	_	_
21	model	model	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	transcription	transcription	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	erythropoietin	erythropoietin	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	3	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	proteins	protein	NNS	NNS	_	1	nmod	_	_
12	binding	bind	VBG	VBG	_	11	acl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	GATA-1	gata-1	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Sp1	sp1	NN	NN	_	14	conj	_	_
17	motifs	motif	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Erythropoietin	erythropoietin	NN	NN	_	16	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Epo	epo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	primary	primary	JJ	JJ	_	8	amod	_	_
8	regulator	regulator	NN	NN	_	1	appos	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	production	production	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	erythroid	erythroid	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	1	punct	_	_
16	acts	act	VBZ	VBZ	_	0	root	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	binding	bind	VBG	VBG	_	16	advcl	_	_
19	to	to	TO	TO	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	surface	surface	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	EpoR	epor	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	on	on	IN	IN	_	29	case	_	_
28	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
29	progenitors	progenitor	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	deletion	deletion	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	transfection	transfection	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	4	conj	_	_
8	with	with	IN	IN	_	11	case	_	_
9	reporter	reporter	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	constructs	construct	NNS	NNS	_	4	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	examine	examine	VB	VB	_	2	advcl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	control	control	NN	NN	_	17	compound	_	_
17	elements	element	NNS	NNS	_	13	dobj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	5'	5'	JJ	JJ	_	22	amod	_	_
21	flanking	flanking	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	EpoR	epor	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	erythroid	erythroid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	most	most	JJS	JJS	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	contained	contain	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	150	150	CD	CD	_	15	nummod	_	_
14	bp	bp	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	fragment	fragment	NN	NN	_	10	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	binding	bind	VBG	VBG	_	19	amod	_	_
19	sites	site	NNS	NNS	_	16	nmod	_	_
20	for	for	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	AP2	ap2	NN	NN	_	22	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	Sp1	sp1	NN	NN	_	23	conj	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	erythroid-specific	erythroid-specific	JJ	JJ	_	29	amod	_	_
29	GATA-1	gata-1	NN	NN	_	23	conj	_	_
30	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	150	150	CD	CD	_	5	nummod	_	_
3	bp	bp	NN	NN	_	5	compound	_	_
4	hEpoR	hepor	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	high	high	JJ	JJ	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	low	low	JJ	JJ	_	7	conj	_	_
10	activity	activity	NN	NN	_	7	dep	_	_
11	in	in	IN	IN	_	13	case	_	_
12	erythroid	erythroid	JJ	JJ	_	13	amod	_	_
13	OCIM1	ocim1	NN	NN	_	6	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	K562	k562	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	,	,	,	,	_	6	punct	_	_
18	respectively	respectively	RB	RB	_	6	advmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	reflecting	reflect	VBG	VBG	_	6	advcl	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	high	high	JJ	JJ	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	low	low	JJ	JJ	_	22	conj	_	_
25	levels	level	NNS	NNS	_	22	dep	_	_
26	of	of	IN	IN	_	29	case	_	_
27	constitutive	constitutive	JJ	JJ	_	29	amod	_	_
28	hEpoR	hepor	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	GATA-1	gata-1	NN	NN	_	15	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Sp1	sp1	NN	NN	_	2	conj	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	sites	site	NNS	NNS	_	2	dep	_	_
7	in	in	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	2	nmod	_	_
10	lacking	lack	VBG	VBG	_	9	acl	_	_
11	a	a	DT	DT	_	13	det	_	_
12	TATA	tata	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	10	dobj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	necessary	necessary	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	high	high	JJ	JJ	_	19	amod	_	_
19	level	level	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Protein-DNA	protein-dna	JJ	JJ	_	3	amod	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	suggested	suggest	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	Sp1	sp1	NN	NN	_	19	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	two	two	CD	CD	_	12	nummod	_	_
9	other	other	JJ	JJ	_	12	amod	_	_
10	CCGCCC	ccgccc	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	6	conj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	erythroid	erythroid	JJ	JJ	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	non-erythroid	non-erythroid	JJ	JJ	_	14	conj	_	_
17	cells	cell	NNS	NNS	_	14	dep	_	_
18	could	could	MD	MD	_	19	aux	_	_
19	bind	bind	VB	VB	_	4	ccomp	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	Sp1	sp1	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	motif	motif	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	increasing	increase	VBG	VBG	_	10	advcl	_	_
3	GATA-1	gata-1	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	2	dobj	_	_
5	via	via	IN	IN	_	6	case	_	_
6	co-transfection	co-transfection	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	we	we	PRP	PRP	_	10	nsubj	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	able	able	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	transactivate	transactivate	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	hEpoR	hepor	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	K562	k562	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	non-erythroid	non-erythroid	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	but	but	CC	CC	_	18	cc	_	_
24	not	not	RB	RB	_	30	neg	_	_
25	in	in	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	highly	highly	RB	RB	_	28	advmod	_	_
28	active	active	JJ	JJ	_	30	amod	_	_
29	OCIM1	ocim1	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	18	conj	_	_
31	,	,	,	,	_	10	punct	_	_
32	although	although	IN	IN	_	37	mark	_	_
33	GATA-1	gata-1	NN	NN	_	34	compound	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	levels	level	NNS	NNS	_	37	nsubj	_	_
36	were	be	VBD	VBD	_	37	cop	_	_
37	comparable	comparable	JJ	JJ	_	10	advcl	_	_
38	in	in	IN	IN	_	39	case	_	_
39	OCIM1	ocim1	NN	NN	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	K562	k562	NN	NN	_	39	conj	_	_
42	.	.	.	.	_	10	punct	_	_

1	Interestingly	interestingly	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	when	when	WRB	WRB	_	5	advmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	mutated	mutate	VBD	VBD	_	22	advcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Sp1	sp1	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	5	punct	_	_
10	resulting	result	VBG	VBG	_	5	advcl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	marked	marked	JJ	JJ	_	14	amod	_	_
14	decrease	decrease	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	hEpoR	hepor	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	we	we	PRP	PRP	_	22	nsubj	_	_
21	could	could	MD	MD	_	22	aux	_	_
22	restore	restore	VB	VB	_	0	root	_	_
23	transactivation	transactivation	NN	NN	_	22	dobj	_	_
24	by	by	IN	IN	_	25	mark	_	_
25	increasing	increase	VBG	VBG	_	22	advcl	_	_
26	GATA-1	gata-1	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	25	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	OCIM1	ocim1	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	while	while	IN	IN	_	8	mark	_	_
6	GATA-1	gata-1	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	transactivate	transactivate	VB	VB	_	21	advcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	EpoR	epor	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	21	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	21	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	hEpoR	hepor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	nmod	_	_
19	does	do	VBZ	VBZ	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	depend	depend	VB	VB	_	3	ccomp	_	_
22	on	on	IN	IN	_	23	case	_	_
23	GATA-1	gata-1	NN	NN	_	21	nmod	_	_
24	alone	alone	RB	RB	_	23	advmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Rather	rather	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	hEpoR	hepor	NN	NN	_	5	compound	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	6	nsubj	_	_
6	depends	depend	VBZ	VBZ	_	0	root	_	_
7	on	on	IN	IN	_	8	case	_	_
8	coordination	coordination	NN	NN	_	6	nmod	_	_
9	between	between	IN	IN	_	10	case	_	_
10	Sp1	sp1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	GATA-1	gata-1	NN	NN	_	10	conj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	cell-specific	cell-specific	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	8	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	23	case	_	_
19	possibly	possibly	RB	RB	_	23	advmod	_	_
20	other	other	JJ	JJ	_	23	amod	_	_
21	Sp1-like	sp1-like	JJ	JJ	_	23	amod	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	16	nmod	_	_
24	,	,	,	,	_	6	punct	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	provide	provide	VB	VB	_	6	xcomp	_	_
27	high	high	JJ	JJ	_	28	dep	_	_
28	level	level	NN	NN	_	31	amod	_	_
29	,	,	,	,	_	28	punct	_	_
30	tissue-specific	tissue-specific	JJ	JJ	_	28	dep	_	_
31	expression	expression	NN	NN	_	26	dobj	_	_
32	.	.	.	.	_	6	punct	_	_

1	Disruption	disruption	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	GATA	gata	NN	NN	_	5	compound	_	_
5	motif	motif	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	Duffy	duffy	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	1	nmod	_	_
11	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
12	erythroid	erythroid	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Duffy-negative	duffy-negative	JJ	JJ	_	17	amod	_	_
17	individuals	individual	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mRNA	mrna	NN	NN	_	23	nsubjpass	_	_
3	for	for	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	Duffy	duffy	NN	NN	_	8	compound	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	group	group	NN	NN	_	8	compound	_	_
8	antigen	antigen	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	erythrocyte	erythrocyte	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	2	appos	_	_
13	for	for	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	Plasmodium	plasmodium	NN	NN	_	18	compound	_	_
16	vivax	vivax	NN	NN	_	18	compound	_	_
17	malaria	malaria	NN	NN	_	18	compound	_	_
18	parasite	parasite	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	has	have	VBZ	VBZ	_	23	aux	_	_
21	recently	recently	RB	RB	_	23	advmod	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	cloned	clone	VBN	VBN	_	0	root	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	shown	show	VBN	VBN	_	23	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	encode	encode	VB	VB	_	25	xcomp	_	_
28	a	a	DT	DT	_	32	det	_	_
29	widely	widely	RB	RB	_	30	advmod	_	_
30	expressed	express	VBN	VBN	_	32	amod	_	_
31	chemokine	chemokine	NN	NN	_	32	compound	_	_
32	receptor	receptor	NN	NN	_	27	dobj	_	_
33	.	.	.	.	_	23	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	Duffy	duffy	NN	NN	_	10	compound	_	_
8	antigen/chemokine	antigen/chemokine	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	15	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	DARC	darc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	composed	compose	VBN	VBN	_	4	ccomp	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	single	single	JJ	JJ	_	19	amod	_	_
19	exon	exon	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	most	most	JJS	JJS	_	23	dep	_	_
23	Duffy-negative	duffy-negative	JJ	JJ	_	24	amod	_	_
24	blacks	black	NNS	NNS	_	25	nsubj	_	_
25	carry	carry	VBP	VBP	_	15	conj	_	_
26	a	a	DT	DT	_	29	det	_	_
27	silent	silent	JJ	JJ	_	29	amod	_	_
28	FY*B	fy*b	NN	NN	_	29	compound	_	_
29	allele	allele	NN	NN	_	25	dobj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	single	single	JJ	JJ	_	33	amod	_	_
33	T	t	NN	NN	_	29	nmod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	C	c	NN	NN	_	36	compound	_	_
36	substitution	substitution	NN	NN	_	25	nmod	_	_
37	at	at	IN	IN	_	38	case	_	_
38	nucleotide	nucleotide	NN	NN	_	36	nmod	_	_
39	-46	-46	CD	CD	_	38	nummod	_	_
40	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	mutation	mutation	NN	NN	_	3	nsubj	_	_
3	impairs	impair	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	disrupting	disrupt	VBG	VBG	_	3	advcl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	site	site	NN	NN	_	11	dobj	_	_
15	for	for	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	GATA1	gata1	NN	NN	_	20	compound	_	_
18	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	With	with	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	recent	recent	JJ	JJ	_	4	amod	_	_
4	characterization	characterization	NN	NN	_	14	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	FY*A	fy*a	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	FY*B	fy*b	NN	NN	_	7	conj	_	_
10	alleles	allele	NNS	NNS	_	7	dep	_	_
11	,	,	,	,	_	14	punct	_	_
12	these	these	DT	DT	_	13	det	_	_
13	findings	finding	NNS	NNS	_	14	nsubj	_	_
14	provide	provide	VBP	VBP	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	basis	basis	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	Duffy	duffy	NN	NN	_	23	compound	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	group	group	NN	NN	_	23	compound	_	_
23	system	system	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	an	a	DT	DT	_	26	det	_	_
26	explanation	explanation	NN	NN	_	17	conj	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	erythroid-specific	erythroid-specific	JJ	JJ	_	30	amod	_	_
30	repression	repression	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	DARC	darc	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	Duffy-negative	duffy-negative	JJ	JJ	_	37	amod	_	_
37	individuals	individual	NNS	NNS	_	30	nmod	_	_
38	.	.	.	.	_	14	punct	_	_

1	Interleukin-2	interleukin-2	NN	NN	_	2	compound	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	10	nsubjpass	_	_
4	in	in	IN	IN	_	8	case	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
6	virus-transformed	virus-transformed	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	controlled	control	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor-chi	factor-chi	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	interleukin	interleukin	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	IL	il	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	-2	-2	CD	CD	_	9	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	2	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	investigated	investigate	VBN	VBN	_	0	root	_	_
14	mainly	mainly	RB	RB	_	17	advmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	predominant	predominant	JJ	JJ	_	21	amod	_	_
21	producers	producer	NNS	NNS	_	17	appos	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubj	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	synthesize	synthesize	VB	VB	_	0	root	_	_
8	IL-2	il-2	NN	NN	_	7	dobj	_	_
9	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	analyzed	analyze	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	control	control	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	22	case	_	_
14	Epstein-Barr	epstein-barr	JJ	JJ	_	22	amod	_	_
15	virus	virus	NN	NN	_	22	compound	_	_
16	(	(	-LRB-	-LRB-	_	22	punct	_	_
17	EBV	ebv	NN	NN	_	22	compound	_	_
18	)	)	-RRB-	-RRB-	_	22	punct	_	_
19	-transformed	-transformed	JJ	JJ	_	22	amod	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	clones	clone	NNS	NNS	_	12	nmod	_	_
23	which	which	WDT	WDT	_	25	nsubj	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	capable	capable	JJ	JJ	_	22	acl:relcl	_	_
26	of	of	IN	IN	_	27	mark	_	_
27	secreting	secrete	VBG	VBG	_	25	advcl	_	_
28	IL-2	il-2	NN	NN	_	27	dobj	_	_
29	at	at	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	low	low	JJ	JJ	_	32	amod	_	_
32	level	level	NN	NN	_	27	nmod	_	_
33	after	after	IN	IN	_	34	case	_	_
34	stimulation	stimulation	NN	NN	_	27	nmod	_	_
35	with	with	IN	IN	_	38	case	_	_
36	phorbol	phorbol	NN	NN	_	38	compound	_	_
37	12-myristate	12-myristate	NN	NN	_	38	compound	_	_
38	13-acetate	13-acetate	NN	NN	_	34	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	the	the	DT	DT	_	43	det	_	_
41	Ca2+	ca2+	NN	NN	_	43	compound	_	_
42	ionophore	ionophore	NN	NN	_	43	compound	_	_
43	ionomycin	ionomycin	NN	NN	_	38	conj	_	_
44	.	.	.	.	_	6	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfections	transfection	NNS	NNS	_	42	nsubjpass	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	3	dobj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	multiples	multiple	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	transcription	transcription	NN	NN	_	12	compound	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	7	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	24	punct	_	_
18	distal	distal	JJ	JJ	_	24	amod	_	_
19	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
20	factor	factor	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	NF	nf	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	-AT	-at	NN	NN	_	12	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	proximal	proximal	JJ	JJ	_	27	amod	_	_
27	NF-AT	nf-at	NN	NN	_	24	conj	_	_
28	,	,	,	,	_	24	punct	_	_
29	AP-1/Octamer	ap-1/octamer	NN	NN	_	24	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	UPS	ups	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	or	or	CC	CC	_	24	cc	_	_
34	NF-chi	nf-chi	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	24	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	TCEd	tced	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	sites	site	NNS	NNS	_	24	dep	_	_
40	-RSB-	-rsb-	-RRB-	-RRB-	_	24	punct	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	performed	perform	VBN	VBN	_	0	root	_	_
43	.	.	.	.	_	42	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	EBV-transformed	ebv-transformed	JJ	JJ	_	4	amod	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	clones	clone	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	chi	chi	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	10	nsubj	_	_
10	exerted	exert	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	strongest	strongest	JJS	JJS	_	14	amod	_	_
13	inducible	inducible	JJ	JJ	_	12	dep	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	;	;	:	:	_	10	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	NF-AT	nf-at	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	20	nsubj	_	_
20	showed	show	VBD	VBD	_	10	parataxis	_	_
21	either	either	CC	CC	_	22	cc:preconj	_	_
22	no	no	DT	DT	_	20	dobj	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	only	only	RB	RB	_	25	advmod	_	_
25	weak	weak	JJ	JJ	_	22	conj	_	_
26	activity	activity	NN	NN	_	22	dep	_	_
27	compared	compare	VBN	VBN	_	31	case	_	_
28	to	to	TO	TO	_	31	case	_	_
29	Jurkat	jurkat	NN	NN	_	31	compound	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	20	advcl	_	_
32	.	.	.	.	_	10	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	12	nsubj	_	_
4	bearing	bear	VBG	VBG	_	3	acl	_	_
5	a	a	DT	DT	_	9	det	_	_
6	defective	defective	JJ	JJ	_	9	amod	_	_
7	NF-chi	nf-chi	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	4	dobj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	completely	completely	RB	RB	_	12	advmod	_	_
12	inactive	inactive	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	EBV-transformed	ebv-transformed	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	while	while	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubj	_	_
20	still	still	RB	RB	_	21	advmod	_	_
21	had	have	VBD	VBD	_	12	advcl	_	_
22	activity	activity	NN	NN	_	21	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	Jurkat	jurkat	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	seven	seven	CD	CD	_	5	nummod	_	_
3	EBV-B	ebv-b	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	22	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	lines	line	NNS	NNS	_	5	conj	_	_
8	differing	differ	VBG	VBG	_	5	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	capacity	capacity	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	secrete	secrete	VB	VB	_	11	acl	_	_
14	IL-2	il-2	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	22	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activity	activity	NN	NN	_	22	nsubj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	correlated	correlate	VBD	VBD	_	0	root	_	_
23	well	well	RB	RB	_	22	advmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	status	status	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	secretion	secretion	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	22	punct	_	_

1	Similarly	similarly	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	19	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	whose	whose	WP$	WP$	_	10	nmod:poss	_	_
10	activity	activity	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	controlled	control	VBN	VBN	_	7	acl:relcl	_	_
13	through	through	IN	IN	_	16	case	_	_
14	chi	chi	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	active	active	JJ	JJ	_	19	xcomp	_	_
23	in	in	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	IL-2	il-2	NN	NN	_	28	compound	_	_
26	producing	producing	NN	NN	_	28	compound	_	_
27	EBV-B	ebv-b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	22	nmod	_	_
29	,	,	,	,	_	22	punct	_	_
30	but	but	CC	CC	_	22	cc	_	_
31	inactive	inactive	JJ	JJ	_	22	conj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	non-IL-2-producing	non-il-2-producing	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	19	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	17	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	extracts	extract	NNS	NNS	_	5	dobj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	EBV-B	ebv-b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	16	det	_	_
13	IL-2	il-2	NN	NN	_	16	compound	_	_
14	NF-chi	nf-chi	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	probe	probe	NN	NN	_	7	conj	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	20	det	_	_
19	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
20	generation	generation	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	chi	chi	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	complexes	complex	NNS	NNS	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	IL-2-secreting	il-2-secreting	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	20	nmod	_	_
28	consisting	consist	VBG	VBG	_	27	acl	_	_
29	mainly	mainly	RB	RB	_	28	advmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	heterodimeric	heterodimeric	JJ	JJ	_	33	amod	_	_
32	p50/p65	p50/p65	NN	NN	_	33	compound	_	_
33	complexes	complex	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	weaker	weaker	JJR	JJR	_	6	amod	_	_
3	chi	chi	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	complex	complex	JJ	JJ	_	6	amod	_	_
6	formation	formation	NN	NN	_	11	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	faster-migrating	faster-migrating	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	6	conj	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	non-IL-2-secreting	non-il-2-secreting	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	IL-2	il-2	NN	NN	_	9	compound	_	_
7	NF-chi	nf-chi	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	indispensable	indispensable	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	EBV-transformed	ebv-transformed	JJ	JJ	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	14	nmod	_	_
23	,	,	,	,	_	11	punct	_	_
24	whereas	whereas	IN	IN	_	28	mark	_	_
25	other	other	JJ	JJ	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	28	nsubj	_	_
28	appear	appear	VBP	VBP	_	11	advcl	_	_
29	to	to	TO	TO	_	32	mark	_	_
30	be	be	VB	VB	_	32	cop	_	_
31	less	less	RBR	RBR	_	32	advmod	_	_
32	important	important	JJ	JJ	_	28	xcomp	_	_
33	for	for	IN	IN	_	35	case	_	_
34	IL-2	il-2	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	32	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	these	these	DT	DT	_	38	det	_	_
38	cells	cell	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	gene	gene	NN	NN	_	2	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	12	det	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	C-type	c-type	JJ	JJ	_	12	amod	_	_
10	lectin	lectin	NN	NN	_	12	compound	_	_
11	leukocyte	leukocyte	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	6	dobj	_	_
13	AIM/CD69	aim/cd69	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	2	cc	_	_
15	functional	functional	JJ	JJ	_	16	amod	_	_
16	characterization	characterization	NN	NN	_	2	conj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
19	tumor	tumor	NN	NN	_	22	compound	_	_
20	necrosis	necrosis	NN	NN	_	22	compound	_	_
21	factor-alpha-responsive	factor-alpha-responsive	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	antigen	antigen	NN	NN	_	8	nsubj	_	_
5	CD69	cd69	NN	NN	_	4	dep	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	a	a	DT	DT	_	8	det	_	_
8	member	member	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	C-type	c-type	JJ	JJ	_	14	amod	_	_
12	animal	animal	NN	NN	_	14	compound	_	_
13	lectin	lectin	NN	NN	_	14	compound	_	_
14	superfamily	superfamily	NN	NN	_	8	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	functions	function	VBZ	VBZ	_	8	acl:relcl	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	signal-transmitting	signal-transmitting	JJ	JJ	_	20	amod	_	_
20	receptor	receptor	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	expression	expression	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CD69	cd69	NN	NN	_	3	nmod	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	29	advcl	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	on	on	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	most	most	JJS	JJS	_	16	amod	_	_
15	hematopoietic	hematopoietic	JJ	JJ	_	16	amod	_	_
16	lineages	lineage	NNS	NNS	_	12	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	wide	wide	JJ	JJ	_	20	amod	_	_
20	variety	variety	NN	NN	_	8	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	stimuli	stimulus	NNS	NNS	_	20	nmod	_	_
23	,	,	,	,	_	29	punct	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vivo	vivo	FW	FW	_	29	advmod	_	_
26	it	it	PRP	PRP	_	29	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	mainly	mainly	RB	RB	_	29	advmod	_	_
29	expressed	express	VBN	VBN	_	0	root	_	_
30	by	by	IN	IN	_	31	case	_	_
31	T-lymphocytes	t-lymphocyte	NNS	NNS	_	29	nmod	_	_
32	located	located	JJ	JJ	_	31	amod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	inflammatory	inflammatory	JJ	JJ	_	36	amod	_	_
36	infiltrates	infiltrate	NNS	NNS	_	32	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	several	several	JJ	JJ	_	40	amod	_	_
39	human	human	JJ	JJ	_	40	amod	_	_
40	diseases	disease	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	29	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	regulate	regulate	VBP	VBP	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	11	det	_	_
8	constitutive	constitutive	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	inducible	inducible	JJ	JJ	_	8	conj	_	_
11	expression	expression	NN	NN	_	6	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CD69	cd69	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	leukocytes	leukocyte	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	isolated	isolate	VBD	VBD	_	2	parataxis	_	_
19	the	the	DT	DT	_	21	det	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	CD69	cd69	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	18	cc	_	_
27	carried	carry	VBD	VBD	_	18	conj	_	_
28	out	out	RP	RP	_	27	compound:prt	_	_
29	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
30	functional	functional	JJ	JJ	_	31	amod	_	_
31	characterization	characterization	NN	NN	_	27	dobj	_	_
32	.	.	.	.	_	2	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	5'-flanking	5'-flanking	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD69	cd69	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	potential	potential	JJ	JJ	_	18	amod	_	_
17	TATA	tata	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	13	nmod	_	_
19	30	30	CD	CD	_	21	nummod	_	_
20	base	base	NN	NN	_	21	compound	_	_
21	pairs	pair	NNS	NNS	_	18	advmod	_	_
22	upstream	upstream	JJ	JJ	_	21	amod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	major	major	JJ	JJ	_	28	amod	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	initiation	initiation	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	several	several	JJ	JJ	_	32	amod	_	_
31	putative	putative	JJ	JJ	_	32	amod	_	_
32	binding	binding	NN	NN	_	33	amod	_	_
33	sequences	sequence	NNS	NNS	_	18	conj	_	_
34	for	for	IN	IN	_	37	case	_	_
35	inducible	inducible	JJ	JJ	_	37	amod	_	_
36	transcription	transcription	NN	NN	_	37	compound	_	_
37	factors	factor	NNS	NNS	_	33	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	37	dep	_	_
41	,	,	,	,	_	40	punct	_	_
42	Egr-1	egr-1	NN	NN	_	40	appos	_	_
43	,	,	,	,	_	40	punct	_	_
44	AP-1	ap-1	NN	NN	_	40	appos	_	_
45	)	)	-RRB-	-RRB-	_	40	punct	_	_
46	,	,	,	,	_	13	punct	_	_
47	which	which	WDT	WDT	_	49	nsubj	_	_
48	might	might	MD	MD	_	49	aux	_	_
49	mediate	mediate	VB	VB	_	13	acl:relcl	_	_
50	the	the	DT	DT	_	52	det	_	_
51	inducible	inducible	JJ	JJ	_	52	amod	_	_
52	expression	expression	NN	NN	_	49	dobj	_	_
53	of	of	IN	IN	_	55	case	_	_
54	this	this	DT	DT	_	55	det	_	_
55	gene	gene	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	11	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	CD69	cd69	NN	NN	_	8	compound	_	_
5	promoter-based	promoter-based	JJ	JJ	_	8	amod	_	_
6	reporter	reporter	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	K562	k562	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	indicated	indicate	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	23	mark	_	_
14	the	the	DT	DT	_	17	det	_	_
15	proximal	proximal	JJ	JJ	_	17	amod	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	23	nsubj	_	_
18	spanning	span	VBG	VBG	_	17	acl	_	_
19	positions	position	NNS	NNS	_	18	dobj	_	_
20	-78	-78	CD	CD	_	19	dep	_	_
21	to	to	TO	TO	_	22	case	_	_
22	+16	+16	CD	CD	_	20	nmod	_	_
23	contained	contain	VBD	VBD	_	12	ccomp	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cis-acting	cis-acting	JJ	JJ	_	26	amod	_	_
26	sequences	sequence	NNS	NNS	_	23	dobj	_	_
27	necessary	necessary	JJ	JJ	_	26	amod	_	_
28	for	for	IN	IN	_	34	case	_	_
29	basal	basal	JJ	JJ	_	34	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	phorbol	phorbol	NN	NN	_	33	nmod:npmod	_	_
32	12-myristate	12-myristate	NN	NN	_	33	nmod:npmod	_	_
33	13-acetate-inducible	13-acetate-inducible	JJ	JJ	_	29	conj	_	_
34	transcription	transcription	NN	NN	_	27	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	CD69	cd69	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	12	punct	_	_

1	Removal	removal	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	upstream	upstream	JJ	JJ	_	5	amod	_	_
5	sequences	sequence	NNS	NNS	_	1	nmod	_	_
6	located	located	JJ	JJ	_	5	amod	_	_
7	between	between	IN	IN	_	8	case	_	_
8	positions	position	NNS	NNS	_	6	nmod	_	_
9	-78	-78	CD	CD	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	-38	-38	CD	CD	_	9	conj	_	_
12	resulted	result	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	decreased	decrease	VBN	VBN	_	16	amod	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	strength	strength	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	abolished	abolish	VBD	VBD	_	12	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	response	response	NN	NN	_	18	dobj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	phorbol	phorbol	NN	NN	_	24	compound	_	_
23	12-myristate	12-myristate	NN	NN	_	24	compound	_	_
24	13-acetate	13-acetate	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	necrosis	necrosis	NN	NN	_	7	compound	_	_
7	factor-alpha	factor-alpha	NN	NN	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	capable	capable	JJ	JJ	_	3	ccomp	_	_
13	of	of	IN	IN	_	14	mark	_	_
14	inducing	induce	VBG	VBG	_	12	advcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD69	cd69	NN	NN	_	21	compound	_	_
21	molecule	molecule	NN	NN	_	17	nmod	_	_
22	as	as	RB	RB	_	17	cc	_	_
23	well	well	RB	RB	_	22	mwe	_	_
24	as	as	IN	IN	_	22	mwe	_	_
25	the	the	DT	DT	_	27	det	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	17	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	fusion	fusion	NN	NN	_	30	compound	_	_
30	plasmids	plasmid	NNS	NNS	_	27	nmod	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	contain	contain	VBP	VBP	_	30	acl:relcl	_	_
33	5'-flanking	5'-flanking	JJ	JJ	_	34	amod	_	_
34	sequences	sequence	NNS	NNS	_	32	dobj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	CD69	cd69	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	12	punct	_	_
40	suggesting	suggest	VBG	VBG	_	12	xcomp	_	_
41	that	that	IN	IN	_	45	mark	_	_
42	this	this	DT	DT	_	43	det	_	_
43	cytokine	cytokine	NN	NN	_	45	nsubj	_	_
44	may	may	MD	MD	_	45	aux	_	_
45	regulate	regulate	VB	VB	_	40	ccomp	_	_
46	in	in	FW	FW	_	47	compound	_	_
47	vivo	vivo	FW	FW	_	45	advmod	_	_
48	the	the	DT	DT	_	49	det	_	_
49	expression	expression	NN	NN	_	45	dobj	_	_
50	of	of	IN	IN	_	51	case	_	_
51	CD69	cd69	NN	NN	_	49	nmod	_	_
52	.	.	.	.	_	3	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Nonradioactive	nonradioactive	JJ	JJ	_	2	amod	_	_
2	quantification	quantification	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	during	during	IN	IN	_	8	case	_	_
8	differentiation	differentiation	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	U937	u937	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	method	method	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	relative	relative	JJ	JJ	_	7	amod	_	_
7	quantification	quantification	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	using	use	VBG	VBG	_	4	acl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	nonradioactive	nonradioactive	JJ	JJ	_	14	amod	_	_
14	assay	assay	NN	NN	_	11	dobj	_	_
15	based	base	VBN	VBN	_	19	case	_	_
16	on	on	IN	IN	_	19	case	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	strand	strand	NN	NN	_	19	compound	_	_
19	competition	competition	NN	NN	_	14	nmod	_	_
20	between	between	IN	IN	_	22	case	_	_
21	identical	identical	JJ	JJ	_	22	amod	_	_
22	sequences	sequence	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	biotin-	biotin-	NN	NN	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	fluorescein-labeled	fluorescein-labeled	JJ	JJ	_	24	conj	_	_
27	amplicon	amplicon	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	probe	probe	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	unlabeled	unlabeled	JJ	JJ	_	33	amod	_	_
33	amplicon	amplicon	NN	NN	_	27	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	target	target	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	during	during	IN	IN	_	38	case	_	_
38	hybridization	hybridization	NN	NN	_	19	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	As	as	IN	IN	_	5	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	target	target	NN	NN	_	4	compound	_	_
4	quantity	quantity	NN	NN	_	5	nsubj	_	_
5	increased	increase	VBD	VBD	_	12	advcl	_	_
6	,	,	,	,	_	12	punct	_	_
7	that	that	DT	DT	_	12	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	double-labeled	double-labeled	JJ	JJ	_	11	amod	_	_
11	probe	probe	NN	NN	_	7	nmod	_	_
12	decreased	decrease	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	accordance	accordance	NN	NN	_	12	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	mass	mass	NN	NN	_	19	compound	_	_
18	action	action	NN	NN	_	19	compound	_	_
19	law	law	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	technique	technique	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	successfully	successfully	RB	RB	_	5	advmod	_	_
5	applied	apply	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	evaluate	evaluate	VB	VB	_	5	xcomp	_	_
8	differences	difference	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	before	before	IN	IN	_	20	nmod	_	_
17	and	and	CC	CC	_	20	cc	_	_
18	after	after	IN	IN	_	20	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	addition	addition	NN	NN	_	8	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	potent	potent	JJ	JJ	_	24	amod	_	_
23	differentiation	differentiation	NN	NN	_	24	compound	_	_
24	inducers	inducer	NNS	NNS	_	20	nmod	_	_
25	:	:	:	:	_	5	punct	_	_
26	12-O-tetradecanoylphorbol	12-o-tetradecanoylphorbol	NN	NN	_	27	compound	_	_
27	13-acetate	13-acetate	NN	NN	_	5	dep	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TPA	tpa	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	a	a	DT	DT	_	33	det	_	_
33	combination	combination	NN	NN	_	27	conj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	all-trans	all-trans	JJ	JJ	_	37	amod	_	_
36	retinoic	retinoic	JJ	JJ	_	37	amod	_	_
37	acid	acid	NN	NN	_	33	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	RA	ra	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	43	compound	_	_
43	D2	d2	NN	NN	_	37	conj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	VD	vd	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	TPA	tpa	NN	NN	_	5	compound	_	_
5	treatment	treatment	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	2	ccomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	binding	binding	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	up-regulation	up-regulation	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	GR	gr	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	while	while	IN	IN	_	27	mark	_	_
22	no	no	DT	DT	_	25	neg	_	_
23	enhanced	enhance	VBN	VBN	_	25	amod	_	_
24	GR	gr	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	perceived	perceive	VBN	VBN	_	7	advcl	_	_
28	with	with	IN	IN	_	31	case	_	_
29	RA	ra	NN	NN	_	31	compound	_	_
30	/VD	/vd	NN	NN	_	31	compound	_	_
31	treatment	treatment	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	5	amod	_	_
4	colony-stimulating	colony-stimulating	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	E-selectin	e-selectin	NN	NN	_	5	conj	_	_
8	expression	expression	NN	NN	_	5	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	cyclosporin	cyclosporin	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	1	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	14	conj	_	_
20	NFAT	nfat	NN	NN	_	19	dep	_	_
21	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	6	amod	_	_
2	factor	factor	NN	NN	_	6	compound	_	_
3	of	of	IN	IN	_	6	amod	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NFAT	nfat	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	originally	originally	RB	RB	_	12	advmod	_	_
12	described	describe	VBN	VBN	_	0	root	_	_
13	as	as	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	T-cell-specific	t-cell-specific	JJ	JJ	_	17	amod	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	12	nmod	_	_
18	athat	athat	WDT	WDT	_	19	nsubj	_	_
19	supported	support	VBD	VBD	_	17	acl:relcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	cytokine	cytokine	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	mediated	mediate	VBD	VBD	_	19	conj	_	_
28	the	the	DT	DT	_	30	det	_	_
29	immunoregulatory	immunoregulatory	JJ	JJ	_	30	compound	_	_
30	effects	effect	NNS	NNS	_	27	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	cyclosporin	cyclosporin	NN	NN	_	33	compound	_	_
33	A	a	NN	NN	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	CsA	csa	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	12	punct	_	_

1	As	as	IN	IN	_	3	mark	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	observed	observe	VBD	VBD	_	13	advcl	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	activated	activate	VBN	VBN	_	7	amod	_	_
6	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	9	nsubj	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	expressed	express	VBD	VBD	_	3	ccomp	_	_
10	NFAT	nfat	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	tested	test	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	16	det	_	_
15	antiinflammatory	antiinflammatory	JJ	JJ	_	16	amod	_	_
16	properties	property	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CsA	csa	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Significantly	significantly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CsA	csa	NN	NN	_	5	nsubj	_	_
4	completely	completely	RB	RB	_	5	advmod	_	_
5	suppressed	suppress	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NFAT	nfat	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	inhibited	inhibit	VBD	VBD	_	5	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	26	case	_	_
18	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	26	amod	_	_
19	colony-stimulating	colony-stimulating	JJ	JJ	_	26	amod	_	_
20	factor	factor	NN	NN	_	26	compound	_	_
21	(	(	-LRB-	-LRB-	_	26	punct	_	_
22	GM-CSF	gm-csf	NN	NN	_	26	compound	_	_
23	)	)	-RRB-	-RRB-	_	26	punct	_	_
24	gene	gene	NN	NN	_	26	compound	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	elements	element	NNS	NNS	_	16	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	use	use	VBP	VBP	_	26	acl:relcl	_	_
29	NFAT	nfat	NN	NN	_	28	dobj	_	_
30	by	by	IN	IN	_	32	case	_	_
31	60	60	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	14	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	CsA	csa	NN	NN	_	3	nsubj	_	_
2	similarly	similarly	RB	RB	_	3	advmod	_	_
3	mediated	mediate	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	reduction	reduction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	up	up	RB	RB	_	9	advmod	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	65	65	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	5	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	5	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	protein	protein	NN	NN	_	13	conj	_	_
16	expression	expression	NN	NN	_	13	dep	_	_
17	in	in	IN	IN	_	20	case	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	CsA	csa	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	suppressed	suppress	VBD	VBD	_	0	root	_	_
4	E-selectin	e-selectin	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	vascular	vascular	JJ	JJ	_	11	amod	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	adhesion	adhesion	NN	NN	_	11	compound	_	_
11	molecule-1	molecule-1	NN	NN	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	VCAM-1	vcam-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	expression	expression	NN	NN	_	4	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	4	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	even	even	RB	RB	_	26	advmod	_	_
21	though	though	IN	IN	_	26	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	E-selectin	e-selectin	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	activated	activate	VBN	VBN	_	3	advcl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	nmod	_	_
30	rather	rather	RB	RB	_	29	cc	_	_
31	than	than	IN	IN	_	30	mwe	_	_
32	NFAT	nfat	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	Hence	hence	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	induction	induction	NN	NN	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	surface	surface	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	this	this	DT	DT	_	12	det	_	_
10	leukocyte	leukocyte	NN	NN	_	12	compound	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecule	molecule	NN	NN	_	7	nmod	_	_
13	by	by	IN	IN	_	20	case	_	_
14	tumor	tumor	NN	NN	_	20	compound	_	_
15	necrosis	necrosis	NN	NN	_	20	compound	_	_
16	factor	factor	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	TNF	tnf	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	-alpha	-alpha	NN	NN	_	3	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	reduced	reduce	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	25	case	_	_
24	40	40	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	presence	presence	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	CsA	csa	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	22	punct	_	_
32	and	and	CC	CC	_	22	cc	_	_
33	this	this	DT	DT	_	35	nsubjpass	_	_
34	was	be	VBD	VBD	_	35	auxpass	_	_
35	reflected	reflect	VBN	VBN	_	22	conj	_	_
36	by	by	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	29	29	CD	CD	_	39	compound	_	_
39	%	%	NN	NN	_	40	nummod	_	_
40	decrease	decrease	NN	NN	_	35	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	neutrophil	neutrophil	NN	NN	_	43	compound	_	_
43	adhesion	adhesion	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CsA	csa	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	at	at	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	chromatin	chromatin	NN	NN	_	15	compound	_	_
14	structure	structure	NN	NN	_	15	compound	_	_
15	level	level	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	as	as	IN	IN	_	31	mark	_	_
18	DNasel	dnasel	NN	NN	_	20	compound	_	_
19	hypersensitive	hypersensitive	JJ	JJ	_	20	amod	_	_
20	sites	site	NNS	NNS	_	31	nsubjpass	_	_
21	within	within	IN	IN	_	25	case	_	_
22	both	both	CC	CC	_	25	cc:preconj	_	_
23	the	the	DT	DT	_	25	det	_	_
24	GM-CSF	gm-csf	NN	NN	_	25	compound	_	_
25	enhancer	enhancer	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	E-selectin	e-selectin	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	conj	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	suppressed	suppress	VBN	VBN	_	10	advcl	_	_
32	by	by	IN	IN	_	33	case	_	_
33	CsA	csa	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	represents	represent	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	report	report	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFAT	nfat	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	suggests	suggest	VBZ	VBZ	_	2	conj	_	_
13	mechanisms	mechanism	NNS	NNS	_	12	dobj	_	_
14	by	by	IN	IN	_	18	case	_	_
15	which	which	WDT	WDT	_	18	dep	_	_
16	CsA	csa	NN	NN	_	18	nsubj	_	_
17	could	could	MD	MD	_	18	aux	_	_
18	function	function	VB	VB	_	13	acl:relcl	_	_
19	as	as	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	antiinflammatory	antiinflammatory	JJ	JJ	_	22	amod	_	_
22	agent	agent	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	14	nsubj	_	_
4	in	in	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	interleukin	interleukin	NN	NN	_	10	compound	_	_
8	2	2	CD	CD	_	10	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	3	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	site	site	NN	NN	_	0	root	_	_
15	for	for	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	zinc	zinc	NN	NN	_	19	compound	_	_
18	finger	finger	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	14	nmod	_	_
20	Sp1	sp1	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	EGR-1	egr-1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	14	punct	_	_

1	Activation	activation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	interleukin	interleukin	NN	NN	_	9	compound	_	_
5	2	2	CD	CD	_	9	nummod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	IL-2	il-2	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	gene	gene	NN	NN	_	1	nmod	_	_
10	after	after	IN	IN	_	12	case	_	_
11	antigen	antigen	NN	NN	_	12	compound	_	_
12	recognition	recognition	NN	NN	_	1	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	critical	critical	JJ	JJ	_	16	amod	_	_
16	event	event	NN	NN	_	0	root	_	_
17	for	for	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	16	nmod	_	_
20	proliferation	proliferation	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	effector	effector	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	19	conj	_	_
24	.	.	.	.	_	16	punct	_	_

1	Prior	prior	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	contribute	contribute	VBP	VBP	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	stimulated	stimulate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	3	dobj	_	_
8	within	within	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	located	located	JJ	JJ	_	11	amod	_	_
13	immediately	immediately	RB	RB	_	14	advmod	_	_
14	upstream	upstream	RB	RB	_	12	advmod	_	_
15	of	of	IN	IN	_	26	case	_	_
16	the	the	DT	DT	_	26	det	_	_
17	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
18	factor	factor	NN	NN	_	26	compound	_	_
19	of	of	IN	IN	_	26	amod	_	_
20	activated	activate	VBN	VBN	_	26	amod	_	_
21	T	t	NN	NN	_	26	compound	_	_
22	cell	cell	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	NFAT	nfat	NN	NN	_	26	compound	_	_
25	)	)	-RRB-	-RRB-	_	26	punct	_	_
26	domain	domain	NN	NN	_	14	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	15	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	termed	term	VBN	VBN	_	2	dep	_	_
5	the	the	DT	DT	_	10	det	_	_
6	zinc	zinc	NN	NN	_	10	compound	_	_
7	finger	finger	NN	NN	_	10	compound	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	4	xcomp	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	ZIP	zip	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	)	)	-RRB-	-RRB-	_	4	punct	_	_
15	serves	serve	VBZ	VBZ	_	0	root	_	_
16	as	as	IN	IN	_	18	case	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	site	site	NN	NN	_	15	nmod	_	_
19	for	for	IN	IN	_	25	case	_	_
20	two	two	CD	CD	_	25	nummod	_	_
21	differently	differently	RB	RB	_	22	advmod	_	_
22	regulated	regulate	VBN	VBN	_	25	amod	_	_
23	zinc	zinc	NN	NN	_	25	compound	_	_
24	finger	finger	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	18	nmod	_	_
26	:	:	:	:	_	15	punct	_	_
27	the	the	DT	DT	_	31	det	_	_
28	constitutively	constitutively	RB	RB	_	31	advmod	_	_
29	expressed	express	VBN	VBN	_	31	amod	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	15	dep	_	_
32	Sp1	sp1	NN	NN	_	31	dep	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	the	the	DT	DT	_	39	det	_	_
35	inducible	inducible	JJ	JJ	_	39	amod	_	_
36	early	early	JJ	JJ	_	39	amod	_	_
37	growth	growth	NN	NN	_	39	compound	_	_
38	response	response	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	31	conj	_	_
40	EGR-1	egr-1	NN	NN	_	39	dep	_	_
41	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	unstimulated	unstimulated	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	12	nmod	_	_
4	which	which	WDT	WDT	_	7	nsubj	_	_
5	do	do	VBP	VBP	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	secrete	secrete	VB	VB	_	3	acl:relcl	_	_
8	IL-2	il-2	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	12	punct	_	_
10	only	only	RB	RB	_	11	advmod	_	_
11	Sp1	sp1	NN	NN	_	12	nsubj	_	_
12	binds	bind	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	region	region	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	while	while	IN	IN	_	27	mark	_	_
18	in	in	IN	IN	_	22	case	_	_
19	stimulated	stimulate	VBN	VBN	_	22	amod	_	_
20	IL-2	il-2	NN	NN	_	22	compound	_	_
21	secreting	secreting	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	27	nmod	_	_
23	the	the	DT	DT	_	26	det	_	_
24	inducible	inducible	JJ	JJ	_	26	amod	_	_
25	EGR-1	egr-1	NN	NN	_	26	compound	_	_
26	protein	protein	NN	NN	_	27	nsubj	_	_
27	recognizes	recognize	VBZ	VBZ	_	12	advcl	_	_
28	this	this	DT	DT	_	29	det	_	_
29	element	element	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	Jurkat	jurkat	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	ZIP	zip	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	9	nsubj	_	_
9	serves	serve	VBZ	VBZ	_	0	root	_	_
10	as	as	IN	IN	_	12	case	_	_
11	an	a	DT	DT	_	12	det	_	_
12	activator	activator	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	IL-2	il-2	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	a	a	DT	DT	_	20	det	_	_
20	combination	combination	NN	NN	_	28	nsubjpass	_	_
21	of	of	IN	IN	_	22	case	_	_
22	ZIP	zip	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NFAT	nfat	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	22	conj	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	required	require	VBN	VBN	_	9	conj	_	_
29	for	for	IN	IN	_	33	case	_	_
30	maximal	maximal	JJ	JJ	_	33	amod	_	_
31	IL-2	il-2	NN	NN	_	32	compound	_	_
32	promoter	promoter	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	critical	critical	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	ZIP	zip	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	6	nmod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	demonstration	demonstration	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NFATp	nfatp	NN	NN	_	5	compound	_	_
5	dephosphorylation	dephosphorylation	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	localization	localization	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	HT-2	ht-2	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	using	use	VBG	VBG	_	2	dep	_	_
14	a	a	DT	DT	_	18	det	_	_
15	specific	specific	JJ	JJ	_	18	amod	_	_
16	NFATp	nfatp	NN	NN	_	18	compound	_	_
17	polyclonal	polyclonal	JJ	JJ	_	18	amod	_	_
18	antibody	antibody	NN	NN	_	13	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	6	amod	_	_
2	factor	factor	NN	NN	_	6	compound	_	_
3	of	of	IN	IN	_	6	amod	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NFAT	nfat	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	regulates	regulate	VBZ	VBZ	_	0	root	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	NFAT	nfat	NN	NN	_	23	compound	_	_
21	DNA	dna	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	stimulated	stimulate	VBN	VBN	_	10	conj	_	_
26	following	follow	VBG	VBG	_	29	case	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	lines	line	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	evidence	evidence	NN	NN	_	2	nmod	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	suggested	suggest	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	NFAT	nfat	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	a	a	DT	DT	_	11	det	_	_
11	substrate	substrate	NN	NN	_	6	ccomp	_	_
12	for	for	IN	IN	_	13	case	_	_
13	calcineurin	calcineurin	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	serine/threonine	serine/threonine	NN	NN	_	17	compound	_	_
17	phosphatase	phosphatase	NN	NN	_	13	appos	_	_
18	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	4	det	_	_
3	polyclonal	polyclonal	JJ	JJ	_	4	amod	_	_
4	antibody	antibody	NN	NN	_	1	dobj	_	_
5	to	to	TO	TO	_	7	case	_	_
6	murine	murine	JJ	JJ	_	7	amod	_	_
7	NFATp	nfatp	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	Western	western	NN	NN	_	11	compound	_	_
10	blot	blot	NN	NN	_	11	compound	_	_
11	analysis	analysis	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	various	various	JJ	JJ	_	15	amod	_	_
14	mouse	mouse	NN	NN	_	15	compound	_	_
15	tissues	tissue	NNS	NNS	_	11	nmod	_	_
16	demonstrated	demonstrate	VBD	VBD	_	1	parataxis	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	110-130-kDa	110-130-kda	JJ	JJ	_	21	amod	_	_
20	NFATp	nfatp	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	24	nsubjpass	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	highly	highly	RB	RB	_	24	advmod	_	_
24	expressed	express	VBN	VBN	_	16	ccomp	_	_
25	in	in	IN	IN	_	26	case	_	_
26	thymus	thymus	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	spleen	spleen	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	1	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	immunoprecipitated	immunoprecipitate	VBN	VBN	_	4	amod	_	_
4	NFATp	nfatp	NN	NN	_	1	nmod	_	_
5	from	from	IN	IN	_	8	case	_	_
6	untreated	untreated	JJ	JJ	_	8	amod	_	_
7	HT-2	ht-2	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	calcineurin	calcineurin	NN	NN	_	1	nmod	_	_
11	resulted	result	VBD	VBD	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	dephosphorylation	dephosphorylation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	NFATp	nfatp	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	demonstrating	demonstrate	VBG	VBG	_	11	xcomp	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	NFATp	nfatp	NN	NN	_	25	nsubj	_	_
21	is	be	VBZ	VBZ	_	25	cop	_	_
22	an	a	DT	DT	_	25	det	_	_
23	in	in	FW	FW	_	25	amod	_	_
24	vitro	vitro	FW	FW	_	23	dep	_	_
25	substrate	substrate	NN	NN	_	18	ccomp	_	_
26	for	for	IN	IN	_	27	case	_	_
27	calcineurin	calcineurin	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	NFATp	nfatp	NN	NN	_	7	nsubj	_	_
2	immunoprecipitated	immunoprecipitate	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	6	case	_	_
4	32P-labeled	32p-labeled	JJ	JJ	_	6	amod	_	_
5	HT-2	ht-2	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	migrated	migrate	VBD	VBD	_	0	root	_	_
8	as	as	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	120-kDa	120-kda	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	7	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	localized	localized	JJ	JJ	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cytosol	cytosol	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Treatment	treatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	ionomycin	ionomycin	NN	NN	_	1	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	decrease	decrease	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	weight	weight	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	NFATp	nfatp	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	a	a	DT	DT	_	19	det	_	_
19	loss	loss	NN	NN	_	10	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	32P	32p	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	7	punct	_	_
23	consistent	consistent	JJ	JJ	_	7	advmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	NFATp	nfatp	NN	NN	_	26	compound	_	_
26	dephosphorylation	dephosphorylation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	dephosphorylation	dephosphorylation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFATp	nfatp	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	localization	localization	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	fraction	fraction	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Both	both	DT	DT	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	1	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	preincubation	preincubation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	FK506	fk506	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	calcineurin	calcineurin	NN	NN	_	17	compound	_	_
17	inhibitor	inhibitor	NN	NN	_	13	appos	_	_
18	,	,	,	,	_	6	punct	_	_
19	consistent	consistent	JJ	JJ	_	6	advmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	hypothesis	hypothesis	NN	NN	_	19	nmod	_	_
23	that	that	IN	IN	_	28	mark	_	_
24	NFATp	nfatp	NN	NN	_	28	nsubj	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	a	a	DT	DT	_	28	det	_	_
27	calcineurin	calcineurin	NN	NN	_	28	compound	_	_
28	substrate	substrate	NN	NN	_	22	ccomp	_	_
29	in	in	IN	IN	_	30	case	_	_
30	cells	cell	NNS	NNS	_	28	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Chromosomal	chromosomal	JJ	JJ	_	2	amod	_	_
2	localization	localization	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	two	two	CD	CD	_	8	nummod	_	_
5	KOX	kox	NN	NN	_	8	compound	_	_
6	zinc	zinc	NN	NN	_	8	compound	_	_
7	finger	finger	NN	NN	_	8	compound	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	chromosome	chromosome	NN	NN	_	11	compound	_	_
11	bands	band	NNS	NNS	_	8	nmod	_	_
12	7q21-q22	7q21-q22	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	cDNAs	cdna	NNS	NNS	_	15	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	Kruppel-type	kruppel-type	JJ	JJ	_	7	amod	_	_
5	zinc	zinc	NN	NN	_	7	compound	_	_
6	finger	finger	NN	NN	_	7	compound	_	_
7	domains	domain	NNS	NNS	_	3	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	designated	designate	VBN	VBN	_	7	acl	_	_
10	KOX	kox	NN	NN	_	9	xcomp	_	_
11	1-32	1-32	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	2	punct	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	cloned	clone	VBN	VBN	_	0	root	_	_
16	from	from	IN	IN	_	22	case	_	_
17	human	human	JJ	JJ	_	22	amod	_	_
18	T	t	NN	NN	_	22	compound	_	_
19	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	libraries	library	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	regional	regional	JJ	JJ	_	6	amod	_	_
6	localizations	localization	NNS	NNS	_	2	dobj	_	_
7	by	by	IN	IN	_	10	case	_	_
8	in	in	FW	FW	_	10	amod	_	_
9	situ	situ	FW	FW	_	8	dep	_	_
10	hybridization	hybridization	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	KOX	kox	NN	NN	_	10	nmod	_	_
13	18	18	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	KOX	kox	NN	NN	_	12	conj	_	_
16	25	25	CD	CD	_	15	nummod	_	_
17	on	on	IN	IN	_	20	case	_	_
18	chromosome	chromosome	NN	NN	_	20	compound	_	_
19	bands	band	NNS	NNS	_	20	compound	_	_
20	7q21q22	7q21q22	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Pulse-field	pulse-field	JJ	JJ	_	3	amod	_	_
2	gel	gel	NN	NN	_	3	compound	_	_
3	electrophoresis	electrophoresis	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PFGE	pfge	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	analysis	analysis	NN	NN	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	these	these	DT	DT	_	11	det	_	_
11	genes	gene	NNS	NNS	_	14	nsubj	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	physically	physically	RB	RB	_	14	advmod	_	_
14	located	located	JJ	JJ	_	8	ccomp	_	_
15	within	within	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	fragment	fragment	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	250	250	CD	CD	_	21	nummod	_	_
21	kb	kb	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	genes	gene	NNS	NNS	_	15	nsubjpass	_	_
3	KOX	kox	NN	NN	_	2	dep	_	_
4	4	4	CD	CD	_	3	nummod	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	KOX	kox	NN	NN	_	3	conj	_	_
7	9	9	CD	CD	_	6	nummod	_	_
8	,	,	,	,	_	2	punct	_	_
9	mapped	map	VBN	VBN	_	2	acl	_	_
10	on	on	IN	IN	_	12	case	_	_
11	chromosome	chromosome	NN	NN	_	12	compound	_	_
12	8q24	8q24	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	located	located	JJ	JJ	_	15	xcomp	_	_
19	within	within	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	fragment	fragment	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	450	450	CD	CD	_	25	nummod	_	_
25	kb	kb	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	present	present	JJ	JJ	_	14	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	previous	previous	JJ	JJ	_	3	conj	_	_
6	data	datum	NNS	NNS	_	3	dep	_	_
7	,	,	,	,	_	14	punct	_	_
8	eighteen	eighteen	CD	CD	_	11	nummod	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	KOX	kox	NN	NN	_	11	compound	_	_
11	genes	gene	NNS	NNS	_	14	nsubj	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	cop	_	_
14	located	located	JJ	JJ	_	0	root	_	_
15	at	at	IN	IN	_	16	case	_	_
16	least	least	JJS	JJS	_	17	advmod	_	_
17	two	two	CD	CD	_	14	dep	_	_
18	by	by	IN	IN	_	19	case	_	_
19	two	two	CD	CD	_	17	nmod	_	_
20	within	within	IN	IN	_	23	case	_	_
21	nine	nine	CD	CD	_	23	nummod	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	fragments	fragment	NNS	NNS	_	14	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	200	200	CD	CD	_	27	compound	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	580	580	CD	CD	_	28	nummod	_	_
28	kb	kb	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	9	case	_	_
3	normal	normal	JJ	JJ	_	9	amod	_	_
4	vitamin	vitamin	NN	NN	_	9	compound	_	_
5	D	d	NN	NN	_	9	compound	_	_
6	receptor	receptor	NN	NN	_	9	compound	_	_
7	messenger	messenger	NN	NN	_	9	compound	_	_
8	ribonucleic	ribonucleic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	1	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	genotype	genotype	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	absorptive	absorptive	JJ	JJ	_	14	amod	_	_
14	hypercalciuria	hypercalciuria	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Absorptive	absorptive	JJ	JJ	_	2	amod	_	_
2	hypercalciuria	hypercalciuria	NN	NN	_	9	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	stone-forming	stone-forming	JJ	JJ	_	6	amod	_	_
6	condition	condition	NN	NN	_	2	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	characterized	characterize	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	gut	gut	NN	NN	_	12	compound	_	_
12	hyperabsorption	hyperabsorption	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	calcium	calcium	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	12	punct	_	_
16	hypercalciuria	hypercalciuria	NN	NN	_	12	appos	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	reduced	reduce	VBN	VBN	_	21	amod	_	_
20	bone	bone	NN	NN	_	21	compound	_	_
21	density	density	NN	NN	_	12	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Inasmuch	inasmuch	RB	RB	_	5	advmod	_	_
2	as	as	IN	IN	_	5	mark	_	_
3	these	these	DT	DT	_	4	det	_	_
4	features	feature	NNS	NNS	_	5	nsubj	_	_
5	implicate	implicate	VBP	VBP	_	15	dep	_	_
6	enhanced	enhance	VBN	VBN	_	8	amod	_	_
7	calcitriol	calcitriol	NN	NN	_	8	compound	_	_
8	action	action	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	gut	gut	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	bone	bone	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	analyzed	analyze	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	23	det	_	_
17	vitamin	vitamin	NN	NN	_	23	compound	_	_
18	D	d	NN	NN	_	23	compound	_	_
19	receptor	receptor	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	VDR	vdr	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	gene	gene	NN	NN	_	15	dobj	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	ascertain	ascertain	VB	VB	_	15	advcl	_	_
26	whether	whether	IN	IN	_	32	mark	_	_
27	an	a	DT	DT	_	28	det	_	_
28	abnormality	abnormality	NN	NN	_	32	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	gene	gene	NN	NN	_	28	nmod	_	_
32	marks	mark	VBZ	VBZ	_	25	ccomp	_	_
33	patients	patient	NNS	NNS	_	32	dobj	_	_
34	with	with	IN	IN	_	36	case	_	_
35	intestinal	intestinal	JJ	JJ	_	36	amod	_	_
36	hyperabsorption	hyperabsorption	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	calcium	calcium	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	compared	compare	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	frequency	frequency	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	restriction	restriction	NN	NN	_	11	compound	_	_
9	fragment	fragment	NN	NN	_	11	compound	_	_
10	length	length	NN	NN	_	11	compound	_	_
11	polymorphism	polymorphism	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	Bsm	bsm	NN	NN	_	14	compound	_	_
14	I	i	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	associated	associate	VBN	VBN	_	11	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	alleles	allele	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	VDR	vdr	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	group	group	NN	NN	_	3	nmod	_	_
27	of	of	IN	IN	_	33	case	_	_
28	33	33	CD	CD	_	33	nummod	_	_
29	well	well	RB	RB	_	30	advmod	_	_
30	characterized	characterize	VBN	VBN	_	33	amod	_	_
31	absorptive	absorptive	JJ	JJ	_	32	dep	_	_
32	hypercalciuric	hypercalciuric	NN	NN	_	30	dep	_	_
33	patients	patient	NNS	NNS	_	26	nmod	_	_
34	and	and	CC	CC	_	26	cc	_	_
35	a	a	DT	DT	_	36	det	_	_
36	group	group	NN	NN	_	26	conj	_	_
37	of	of	IN	IN	_	44	case	_	_
38	36	36	CD	CD	_	44	nummod	_	_
39	normal	normal	JJ	JJ	_	44	amod	_	_
40	race-	race-	NN	NN	_	39	dep	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	age-matched	age-matched	JJ	JJ	_	40	conj	_	_
43	control	control	JJ	JJ	_	44	amod	_	_
44	subjects	subject	NNS	NNS	_	36	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	difference	difference	NN	NN	_	2	nsubj	_	_
5	between	between	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	distribution	distribution	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	VDR	vdr	NN	NN	_	11	compound	_	_
11	alleles	allele	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	patient	patient	NN	NN	_	15	compound	_	_
15	population	population	NN	NN	_	11	nmod	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	compared	compare	VBN	VBN	_	2	advcl	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	normal	normal	JJ	JJ	_	21	amod	_	_
21	population	population	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	coding	code	VBG	VBG	_	3	amod	_	_
3	region	region	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	VDR	vdr	NN	NN	_	7	compound	_	_
6	messenger	messenger	NN	NN	_	7	compound	_	_
7	RNA	rna	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	normal	normal	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	as	as	IN	IN	_	13	mark	_	_
13	determined	determine	VBN	VBN	_	10	advcl	_	_
14	by	by	IN	IN	_	18	case	_	_
15	both	both	CC	CC	_	18	cc:preconj	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	18	compound	_	_
18	analysis	analysis	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	chemical	chemical	JJ	JJ	_	23	amod	_	_
21	mismatch	mismatch	NN	NN	_	23	compound	_	_
22	cleavage	cleavage	NN	NN	_	23	compound	_	_
23	analysis	analysis	NN	NN	_	18	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	copy	copy	NN	NN	_	26	compound	_	_
26	DNA	dna	NN	NN	_	18	nmod	_	_
27	from	from	IN	IN	_	32	case	_	_
28	11	11	CD	CD	_	32	nummod	_	_
29	index	index	NN	NN	_	32	compound	_	_
30	absorptive	absorptive	JJ	JJ	_	31	dep	_	_
31	hypercalciuric	hypercalciuric	NN	NN	_	32	amod	_	_
32	patients	patient	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	10	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	9	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	results	result	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	propose	propose	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	29	mark	_	_
11	the	the	DT	DT	_	15	det	_	_
12	enhanced	enhance	VBN	VBN	_	15	amod	_	_
13	intestinal	intestinal	JJ	JJ	_	15	amod	_	_
14	calcium	calcium	NN	NN	_	15	compound	_	_
15	absorption	absorption	NN	NN	_	29	nsubj	_	_
16	invariably	invariably	RB	RB	_	17	advmod	_	_
17	seen	see	VBN	VBN	_	15	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	absorptive	absorptive	JJ	JJ	_	20	amod	_	_
20	hypercalciuria	hypercalciuria	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	attendant	attendant	JJ	JJ	_	23	amod	_	_
23	symptoms	symptom	NNS	NNS	_	15	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	disorder	disorder	NN	NN	_	23	nmod	_	_
27	are	be	VBP	VBP	_	29	cop	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	attributable	attributable	JJ	JJ	_	9	ccomp	_	_
30	to	to	TO	TO	_	31	case	_	_
31	mutations	mutation	NNS	NNS	_	29	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	VDR	vdr	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	are	be	VBP	VBP	_	38	auxpass	_	_
37	not	not	RB	RB	_	38	neg	_	_
38	linked	link	VBN	VBN	_	29	conj	_	_
39	to	to	TO	TO	_	43	case	_	_
40	a	a	DT	DT	_	43	det	_	_
41	common	common	JJ	JJ	_	43	amod	_	_
42	VDR	vdr	NN	NN	_	43	compound	_	_
43	genotype	genotype	NN	NN	_	38	nmod	_	_
44	.	.	.	.	_	9	punct	_	_

1	Up-regulation	up-regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	high-affinity	high-affinity	JJ	JJ	_	6	amod	_	_
4	dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	activated	activate	VBN	VBN	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	18	advcl	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DHEA	dhea	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	exerts	exert	VBZ	VBZ	_	3	ccomp	_	_
10	direct	direct	JJ	JJ	_	12	amod	_	_
11	physiological	physiological	JJ	JJ	_	10	dep	_	_
12	effects	effect	NNS	NNS	_	9	dobj	_	_
13	,	,	,	,	_	18	punct	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	mechanism	mechanism	NN	NN	_	18	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	action	action	NN	NN	_	15	nmod	_	_
18	remains	remain	VBZ	VBZ	_	0	root	_	_
19	unknown	unknown	JJ	JJ	_	18	xcomp	_	_
20	.	.	.	.	_	18	punct	_	_

1	DHEA	dhea	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	sites	site	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	using	use	VBG	VBG	_	5	xcomp	_	_
7	a	a	DT	DT	_	10	det	_	_
8	whole-cell	whole-cell	JJ	JJ	_	10	amod	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	17	case	_	_
12	a	a	DT	DT	_	17	det	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	6	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	PEER	peer	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	6	punct	_	_
21	revealing	reveal	VBG	VBG	_	6	parataxis	_	_
22	that	that	IN	IN	_	51	mark	_	_
23	a	a	DT	DT	_	25	det	_	_
24	single	single	JJ	JJ	_	25	amod	_	_
25	class	class	NN	NN	_	51	nsubjpass	_	_
26	of	of	IN	IN	_	29	case	_	_
27	high-affinity	high-affinity	JJ	JJ	_	29	amod	_	_
28	binding	bind	VBG	VBG	_	29	amod	_	_
29	sites	site	NNS	NNS	_	25	nmod	_	_
30	for	for	IN	IN	_	31	case	_	_
31	DHEA	dhea	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	dissociation	dissociation	NN	NN	_	34	compound	_	_
34	constant	constant	NN	NN	_	31	dep	_	_
35	=	=	JJ	JJ	_	34	amod	_	_
36	7.4	7.4	CD	CD	_	39	nummod	_	_
37	+/-	+/-	CC	CC	_	36	cc	_	_
38	0.53	0.53	CD	CD	_	36	conj	_	_
39	nmol/L	nmol/l	NN	NN	_	35	dep	_	_
40	,	,	,	,	_	34	punct	_	_
41	mean	mean	NN	NN	_	34	appos	_	_
42	+/-	+/-	CC	CC	_	41	cc	_	_
43	SE	se	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	34	punct	_	_
45	n	n	NN	NN	_	34	appos	_	_
46	=	=	JJ	JJ	_	45	amod	_	_
47	4	4	CD	CD	_	46	dep	_	_
48	)	)	-RRB-	-RRB-	_	34	punct	_	_
49	was	be	VBD	VBD	_	51	auxpass	_	_
50	greatly	greatly	RB	RB	_	51	advmod	_	_
51	increased	increase	VBN	VBN	_	21	ccomp	_	_
52	when	when	WRB	WRB	_	53	advmod	_	_
53	treated	treat	VBN	VBN	_	51	advcl	_	_
54	with	with	IN	IN	_	55	case	_	_
55	DHEA	dhea	NN	NN	_	53	nmod	_	_
56	,	,	,	,	_	55	punct	_	_
57	phorbol-12-myristate-13-acetate	phorbol-12-myristate-13-acetate	NN	NN	_	55	conj	_	_
58	,	,	,	,	_	55	punct	_	_
59	and	and	CC	CC	_	55	cc	_	_
60	the	the	DT	DT	_	63	det	_	_
61	Ca2+	ca2+	NN	NN	_	63	compound	_	_
62	ionophore	ionophore	NN	NN	_	63	compound	_	_
63	A23187	a23187	NN	NN	_	55	conj	_	_
64	.	.	.	.	_	5	punct	_	_

1	Bound	bind	VBN	VBN	_	2	amod	_	_
2	-LSB-3H-RSB-DHEA	-lsb-3h-rsb-dhea	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	displaced	displaced	JJ	JJ	_	0	root	_	_
5	sensitively	sensitively	RB	RB	_	4	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	DHEA	dhea	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	secondarily	secondarily	RB	RB	_	11	advmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	dihydrotestosterone	dihydrotestosterone	NN	NN	_	5	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	5	cc	_	_
15	effectively	effectively	RB	RB	_	18	advmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	steroids	steroid	NNS	NNS	_	5	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	22	case	_	_
21	DHEA	dhea	NN	NN	_	22	compound	_	_
22	sulfate	sulfate	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	only	only	RB	RB	_	5	cc:preconj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	existence	existence	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	DHEA	dhea	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	but	but	CC	CC	_	5	cc	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	suggest	suggest	VBP	VBP	_	5	conj	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	19	nsubj	_	_
19	become	become	VBP	VBP	_	15	ccomp	_	_
20	susceptible	susceptible	JJ	JJ	_	19	xcomp	_	_
21	to	to	TO	TO	_	22	case	_	_
22	regulation	regulation	NN	NN	_	20	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	DHEA	dhea	NN	NN	_	22	nmod	_	_
25	during	during	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	process	process	NN	NN	_	19	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	signal-induced	signal-induced	JJ	JJ	_	30	amod	_	_
30	activation	activation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	Temperature-induced	temperature-induced	JJ	JJ	_	2	amod	_	_
2	down-regulation	down-regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	leucocyte	leucocyte	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	sepsis	sepsis	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	septic	septic	JJ	JJ	_	18	amod	_	_
18	shock	shock	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Activation	activation	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	7	amod	_	_
7	axis	axis	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	of	of	IN	IN	_	11	case	_	_
10	vital	vital	JJ	JJ	_	11	amod	_	_
11	importance	importance	NN	NN	_	1	dep	_	_
12	during	during	IN	IN	_	14	case	_	_
13	critical	critical	JJ	JJ	_	14	amod	_	_
14	illness	illness	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	adaptive	adaptive	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	occur	occur	VBP	VBP	_	6	acl:relcl	_	_
9	at	at	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	level	level	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	19	compound	_	_
18	target	target	NN	NN	_	19	compound	_	_
19	tissues	tissue	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	patients	patient	NNS	NNS	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	sepsis	sepsis	NN	NN	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	septic	septic	JJ	JJ	_	26	amod	_	_
26	shock	shock	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	DESIGN	design	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	23	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	hypercortisolaemia	hypercortisolaemia	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	hyperthermia	hyperthermia	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	composition	composition	NN	NN	_	6	conj	_	_
12	on	on	IN	IN	_	13	case	_	_
13	number	number	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	nmod	_	_
17	per	per	IN	IN	_	18	case	_	_
18	cell	cell	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	affinity	affinity	NN	NN	_	13	conj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	evaluated	evaluate	VBN	VBN	_	1	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	both	both	CC	CC	_	28	cc:preconj	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	28	advmod	_	_
28	and	and	CC	CC	_	23	advmod	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vivo	vivo	FW	FW	_	28	advmod	_	_
31	,	,	,	,	_	23	punct	_	_
32	in	in	IN	IN	_	36	case	_	_
33	peripheral	peripheral	JJ	JJ	_	36	amod	_	_
34	blood	blood	NN	NN	_	36	compound	_	_
35	mononuclear	mononuclear	JJ	JJ	_	36	amod	_	_
36	leucocytes	leucocyte	NNS	NNS	_	23	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	control	control	JJ	JJ	_	39	amod	_	_
39	subjects	subject	NNS	NNS	_	36	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	in	in	IN	IN	_	42	case	_	_
42	patients	patient	NNS	NNS	_	39	conj	_	_
43	with	with	IN	IN	_	44	case	_	_
44	sepsis	sepsis	NN	NN	_	42	nmod	_	_
45	or	or	CC	CC	_	44	cc	_	_
46	septic	septic	JJ	JJ	_	47	amod	_	_
47	shock	shock	NN	NN	_	44	conj	_	_
48	.	.	.	.	_	1	punct	_	_

1	SUBJECTS	subject	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Fifteen	fifteen	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	23	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	age	age	NN	NN	_	4	appos	_	_
7	25-79	25-79	CD	CD	_	6	nummod	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	with	with	IN	IN	_	10	case	_	_
10	sepsis	sepsis	NN	NN	_	4	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	septic	septic	JJ	JJ	_	13	amod	_	_
13	shock	shock	NN	NN	_	10	conj	_	_
14	who	who	WP	WP	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	admitted	admit	VBN	VBN	_	4	acl:relcl	_	_
17	to	to	TO	TO	_	21	case	_	_
18	an	a	DT	DT	_	21	det	_	_
19	intensive	intensive	JJ	JJ	_	21	amod	_	_
20	care	care	NN	NN	_	21	compound	_	_
21	unit	unit	NN	NN	_	16	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	studied	study	VBN	VBN	_	1	dep	_	_
24	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	control	control	JJ	JJ	_	3	amod	_	_
3	group	group	NN	NN	_	4	nsubj	_	_
4	consisted	consist	VBD	VBD	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	24	24	CD	CD	_	9	nummod	_	_
7	healthy	healthy	JJ	JJ	_	9	amod	_	_
8	laboratory	laboratory	NN	NN	_	9	compound	_	_
9	employees	employee	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	MEASUREMENTS	measurement	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	5	dep	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	capacity	capacity	NN	NN	_	13	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	affinity	affinity	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	5	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	measured	measure	VBN	VBN	_	1	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	compared	compare	VBN	VBN	_	13	conj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	clinical	clinical	JJ	JJ	_	18	amod	_	_
18	data	datum	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	plasma	plasma	NN	NN	_	23	compound	_	_
22	cortisol	cortisol	NN	NN	_	23	compound	_	_
23	concentrations	concentration	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Hypercortisolaemia	hypercortisolaemia	NN	NN	_	8	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vitro	vitro	FW	FW	_	8	advmod	_	_
7	,	,	,	,	_	8	punct	_	_
8	resulted	result	VBD	VBD	_	1	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	decreased	decrease	VBN	VBN	_	12	amod	_	_
12	affinity	affinity	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	17	det	_	_
15	decreased	decrease	VBN	VBN	_	17	amod	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	capacity	capacity	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	12	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	15	advmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	hyperthermia	hyperthermia	NN	NN	_	15	nsubj	_	_
5	as	as	RB	RB	_	4	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	variations	variation	NNS	NNS	_	4	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	composition	composition	NN	NN	_	8	nmod	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	influence	influence	VB	VB	_	0	root	_	_
16	the	the	DT	DT	_	18	det	_	_
17	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	15	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	5	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	was	be	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	change	change	NN	NN	_	5	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	receptors	receptor	NNS	NNS	_	10	nmod	_	_
13	per	per	IN	IN	_	14	case	_	_
14	cell	cell	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	10	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	sepsis	sepsis	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	septic	septic	JJ	JJ	_	21	amod	_	_
21	shock	shock	NN	NN	_	18	conj	_	_
22	as	as	IN	IN	_	23	mark	_	_
23	compared	compare	VBN	VBN	_	5	advcl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	healthy	healthy	JJ	JJ	_	26	amod	_	_
26	controls	control	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	decreased	decrease	VBN	VBN	_	5	amod	_	_
5	affinity	affinity	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	8	det	_	_
4	weak	weak	JJ	JJ	_	8	amod	_	_
5	but	but	CC	CC	_	4	cc	_	_
6	significant	significant	JJ	JJ	_	4	conj	_	_
7	negative	negative	JJ	JJ	_	6	dep	_	_
8	correlation	correlation	NN	NN	_	2	nsubj	_	_
9	between	between	IN	IN	_	11	case	_	_
10	body	body	NN	NN	_	11	compound	_	_
11	temperature	temperature	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	patient	patient	NN	NN	_	21	compound	_	_
21	group	group	NN	NN	_	2	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	relation	relation	NN	NN	_	2	nsubj	_	_
5	between	between	IN	IN	_	8	case	_	_
6	circulating	circulate	VBG	VBG	_	8	amod	_	_
7	cortisol	cortisol	NN	NN	_	8	compound	_	_
8	concentrations	concentration	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	8	conj	_	_
12	affinity	affinity	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	number	number	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	There	there	EX	EX	_	4	expl	_	_
4	is	be	VBZ	VBZ	_	1	dep	_	_
5	no	no	DT	DT	_	7	neg	_	_
6	obvious	obvious	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	4	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	plasma	plasma	NN	NN	_	17	compound	_	_
16	cortisol	cortisol	NN	NN	_	17	compound	_	_
17	concentrations	concentration	NNS	NNS	_	7	nmod	_	_
18	in	in	FW	FW	_	17	amod	_	_
19	vivo	vivo	FW	FW	_	18	dep	_	_
20	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	decreased	decrease	VBN	VBN	_	3	amod	_	_
3	affinity	affinity	NN	NN	_	28	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	3	nmod	_	_
8	together	together	RB	RB	_	3	advmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	negative	negative	JJ	JJ	_	12	amod	_	_
12	correlation	correlation	NN	NN	_	3	nmod	_	_
13	between	between	IN	IN	_	14	case	_	_
14	hyperthermia	hyperthermia	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	number	number	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	glucocorticoid	glucocorticoid	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	patients	patient	NNS	NNS	_	17	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	sepsis	sepsis	NN	NN	_	22	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	septic	septic	JJ	JJ	_	27	amod	_	_
27	shock	shock	NN	NN	_	24	conj	_	_
28	suggest	suggest	VBP	VBP	_	0	root	_	_
29	that	that	IN	IN	_	37	mark	_	_
30	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	32	amod	_	_
31	axis	axis	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	37	nsubjpass	_	_
33	during	during	IN	IN	_	35	case	_	_
34	critical	critical	JJ	JJ	_	35	amod	_	_
35	illness	illness	NN	NN	_	32	nmod	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	accompanied	accompany	VBN	VBN	_	28	ccomp	_	_
38	by	by	IN	IN	_	40	case	_	_
39	peripheral	peripheral	JJ	JJ	_	40	amod	_	_
40	adaptation	adaptation	NN	NN	_	37	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	glucocorticoid	glucocorticoid	NN	NN	_	43	compound	_	_
43	receptor	receptor	NN	NN	_	40	nmod	_	_
44	number	number	NN	NN	_	43	dep	_	_
45	and	and	CC	CC	_	43	cc	_	_
46	affinity	affinity	NN	NN	_	43	conj	_	_
47	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	properties	property	NNS	NNS	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	two	two	CD	CD	_	8	nummod	_	_
6	heat	heat	NN	NN	_	8	compound	_	_
7	shock	shock	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	HSF1	hsf1	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	HSF3	hsf3	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	avian	avian	JJ	JJ	_	21	amod	_	_
19	erythroblast	erythroblast	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	15	nmod	_	_
22	HD6	hd6	NN	NN	_	21	dep	_	_
23	.	.	.	.	_	15	punct	_	_

1	Avian	avian	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	three	three	CD	CD	_	12	nummod	_	_
5	heat	heat	NN	NN	_	12	compound	_	_
6	shock	shock	NN	NN	_	12	compound	_	_
7	transcription	transcription	NN	NN	_	12	compound	_	_
8	factor	factor	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	HSF	hsf	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	genes	gene	NNS	NNS	_	3	dobj	_	_
13	corresponding	correspond	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	novel	novel	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	HSF3	hsf3	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	homologs	homolog	NNS	NNS	_	17	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	mouse	mouse	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	human	human	JJ	JJ	_	24	conj	_	_
27	HSF1	hsf1	NN	NN	_	24	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	HSF2	hsf2	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	biochemical	biochemical	JJ	JJ	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cell	cell	NN	NN	_	4	conj	_	_
7	biological	biological	JJ	JJ	_	6	amod	_	_
8	properties	property	NNS	NNS	_	4	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	HSFs	hsf	NNS	NNS	_	4	nmod	_	_
12	reveals	reveal	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	15	mark	_	_
14	HSF3	hsf3	NN	NN	_	15	nsubj	_	_
15	has	have	VBZ	VBZ	_	12	ccomp	_	_
16	properties	property	NNS	NNS	_	15	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	common	common	JJ	JJ	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	HSF1	hsf1	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	HSF2	hsf2	NN	NN	_	21	conj	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	yet	yet	RB	RB	_	26	advmod	_	_
26	has	have	VBZ	VBZ	_	15	conj	_	_
27	features	feature	NNS	NNS	_	26	dobj	_	_
28	which	which	WDT	WDT	_	27	dep	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	distinct	distinct	JJ	JJ	_	27	dep	_	_
31	from	from	IN	IN	_	32	case	_	_
32	both	both	DT	DT	_	30	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	HSF3	hsf3	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	constitutively	constitutively	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	erythroblast	erythroblast	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	line	line	NN	NN	_	10	compound	_	_
10	HD6	hd6	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	the	the	DT	DT	_	16	det	_	_
13	lymphoblast	lymphoblast	NN	NN	_	16	compound	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	line	line	NN	NN	_	16	compound	_	_
16	MSB	msb	NN	NN	_	10	conj	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	embryo	embryo	NN	NN	_	20	compound	_	_
20	fibroblasts	fibroblast	NNS	NNS	_	10	conj	_	_
21	,	,	,	,	_	4	punct	_	_
22	and	and	CC	CC	_	4	cc	_	_
23	yet	yet	RB	RB	_	28	advmod	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	activity	activity	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	induced	induce	VBN	VBN	_	4	conj	_	_
29	only	only	RB	RB	_	28	advmod	_	_
30	upon	upon	IN	IN	_	31	case	_	_
31	exposure	exposure	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	HD6	hd6	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	to	to	TO	TO	_	37	case	_	_
36	heat	heat	NN	NN	_	37	compound	_	_
37	shock	shock	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Acquisition	acquisition	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HSF3	hsf3	NN	NN	_	5	compound	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	HD6	hd6	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	accompanied	accompany	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	oligomerization	oligomerization	NN	NN	_	10	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	non-DNA-binding	non-dna-binding	JJ	JJ	_	16	amod	_	_
16	dimer	dimer	NN	NN	_	12	nmod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	trimer	trimer	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	whereas	whereas	IN	IN	_	31	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	31	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	heat	heat	NN	NN	_	27	compound	_	_
27	shock	shock	NN	NN	_	24	nmod	_	_
28	on	on	IN	IN	_	29	case	_	_
29	HSF1	hsf1	NN	NN	_	24	nmod	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	oligomerization	oligomerization	NN	NN	_	10	advcl	_	_
32	of	of	IN	IN	_	35	case	_	_
33	an	a	DT	DT	_	35	det	_	_
34	inert	inert	JJ	JJ	_	35	amod	_	_
35	monomer	monomer	NN	NN	_	31	nmod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	DNA-binding	dna-binding	JJ	JJ	_	39	amod	_	_
39	trimer	trimer	NN	NN	_	31	nmod	_	_
40	.	.	.	.	_	10	punct	_	_

1	Induction	induction	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	HSF3	hsf3	NN	NN	_	5	compound	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	delayed	delay	VBN	VBN	_	0	root	_	_
8	compared	compare	VBN	VBN	_	10	case	_	_
9	with	with	IN	IN	_	10	case	_	_
10	that	that	DT	DT	_	7	advcl	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HSF1	hsf1	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	occurs	occur	VBZ	VBZ	_	8	advcl	_	_
3	for	for	IN	IN	_	4	case	_	_
4	HSF1	hsf1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	heat	heat	NN	NN	_	7	compound	_	_
7	shock	shock	NN	NN	_	8	nsubj	_	_
8	leads	lead	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	translocation	translocation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HSF3	hsf3	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nucleus	nucleus	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	HSF	hsf	NN	NN	_	2	nsubj	_	_
2	exhibits	exhibit	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	properties	property	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activator	activator	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	judged	judge	VBN	VBN	_	2	advcl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	stimulatory	stimulatory	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	transiently	transiently	RB	RB	_	19	advmod	_	_
18	overexpressed	overexpress	VBN	VBN	_	19	amod	_	_
19	HSF3	hsf3	NN	NN	_	15	nmod	_	_
20	measured	measure	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	using	use	VBG	VBG	_	20	advcl	_	_
23	a	a	DT	DT	_	28	det	_	_
24	heat	heat	NN	NN	_	28	compound	_	_
25	shock	shock	NN	NN	_	28	compound	_	_
26	element-containing	element-containing	JJ	JJ	_	28	amod	_	_
27	reporter	reporter	NN	NN	_	28	compound	_	_
28	construct	construct	NN	NN	_	22	dobj	_	_
29	and	and	CC	CC	_	11	cc	_	_
30	as	as	IN	IN	_	32	mark	_	_
31	independently	independently	RB	RB	_	32	advmod	_	_
32	assayed	assay	VBN	VBN	_	11	conj	_	_
33	by	by	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	activity	activity	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	chimeric	chimeric	JJ	JJ	_	40	amod	_	_
39	GAL4-HSF3	gal4-hsf3	NN	NN	_	40	compound	_	_
40	protein	protein	NN	NN	_	35	nmod	_	_
41	on	on	IN	IN	_	45	case	_	_
42	a	a	DT	DT	_	45	det	_	_
43	GAL4	gal4	NN	NN	_	45	compound	_	_
44	reporter	reporter	NN	NN	_	45	compound	_	_
45	construct	construct	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	HSF3	hsf3	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	negatively	negatively	RB	RB	_	8	advmod	_	_
8	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	avian	avian	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	acquires	acquire	VBZ	VBZ	_	8	conj	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	certain	certain	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	upon	upon	IN	IN	_	21	case	_	_
20	heat	heat	NN	NN	_	21	compound	_	_
21	shock	shock	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	N-	n-	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	C-terminal	c-terminal	JJ	JJ	_	1	conj	_	_
4	sequences	sequence	NNS	NNS	_	5	nsubj	_	_
5	control	control	VBP	VBP	_	0	root	_	_
6	degradation	degradation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	MAD3/I	mad3/i	NN	NN	_	11	compound	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	response	response	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	inducers	inducer	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proteolytic	proteolytic	JJ	JJ	_	3	amod	_	_
3	degradation	degradation	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	MAD3/I	mad3/i	NN	NN	_	11	compound	_	_
9	kappa	kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	7	dep	_	_
12	in	in	IN	IN	_	13	case	_	_
13	response	response	NN	NN	_	3	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	extracellular	extracellular	JJ	JJ	_	16	amod	_	_
16	stimulation	stimulation	NN	NN	_	13	nmod	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	a	a	DT	DT	_	20	det	_	_
19	prerequisite	prerequisite	JJ	JJ	_	20	amod	_	_
20	step	step	NN	NN	_	0	root	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activation	activation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	23	nmod	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	27	dep	_	_
30	.	.	.	.	_	20	punct	_	_

1	Analysis	analysis	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	11	case	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	I	i	NN	NN	_	11	compound	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	stable	stable	JJ	JJ	_	14	amod	_	_
14	transfectants	transfectant	NNS	NNS	_	4	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	mouse	mouse	NN	NN	_	18	compound	_	_
17	70Z/3	70z/3	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	shows	show	VBZ	VBZ	_	0	root	_	_
20	that	that	IN	IN	_	35	mark	_	_
21	,	,	,	,	_	35	punct	_	_
22	as	as	IN	IN	_	27	case	_	_
23	for	for	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	endogenous	endogenous	JJ	JJ	_	27	amod	_	_
26	murine	murine	JJ	JJ	_	27	amod	_	_
27	protein	protein	NN	NN	_	35	nmod	_	_
28	,	,	,	,	_	35	punct	_	_
29	exogenous	exogenous	JJ	JJ	_	33	amod	_	_
30	I	i	NN	NN	_	33	compound	_	_
31	kappa	kappa	NN	NN	_	33	compound	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	35	nsubjpass	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	degraded	degrade	VBN	VBN	_	19	ccomp	_	_
36	in	in	IN	IN	_	37	case	_	_
37	response	response	NN	NN	_	35	nmod	_	_
38	to	to	TO	TO	_	39	case	_	_
39	inducers	inducer	NNS	NNS	_	37	nmod	_	_
40	of	of	IN	IN	_	43	case	_	_
41	NF-kappa	nf-kappa	NN	NN	_	42	compound	_	_
42	B	b	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	39	nmod	_	_
44	,	,	,	,	_	39	punct	_	_
45	such	such	JJ	JJ	_	49	case	_	_
46	as	as	IN	IN	_	45	mwe	_	_
47	phorbol	phorbol	NN	NN	_	49	compound	_	_
48	myristate	myristate	NN	NN	_	49	compound	_	_
49	acetate	acetate	NN	NN	_	39	nmod	_	_
50	or	or	CC	CC	_	49	cc	_	_
51	lipopolysaccharide	lipopolysaccharide	NN	NN	_	49	conj	_	_
52	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	pretreatment	pretreatment	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	proteasome	proteasome	JJ	JJ	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	4	nmod	_	_
12	N-Ac-Leu-Leu-norleucinal	n-ac-leu-leu-norleucinal	NN	NN	_	11	dep	_	_
13	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
14	this	this	DT	DT	_	16	det	_	_
15	ligand-induced	ligand-induced	JJ	JJ	_	16	amod	_	_
16	degradation	degradation	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	,	,	,	,	_	13	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	agreement	agreement	NN	NN	_	13	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	previous	previous	JJ	JJ	_	23	amod	_	_
23	studies	study	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	stabilizes	stabilize	VBZ	VBZ	_	13	dep	_	_
26	a	a	DT	DT	_	28	det	_	_
27	hyperphosphorylated	hyperphosphorylated	JJ	JJ	_	28	amod	_	_
28	form	form	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	36	case	_	_
30	the	the	DT	DT	_	36	det	_	_
31	human	human	JJ	JJ	_	36	amod	_	_
32	I	i	NN	NN	_	36	compound	_	_
33	kappa	kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	alpha	alpha	NN	NN	_	36	compound	_	_
36	protein	protein	NN	NN	_	28	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	expressing	express	VBG	VBG	_	17	advcl	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	forms	form	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	this	this	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	we	we	PRP	PRP	_	17	nsubj	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	cop	_	_
17	able	able	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	delineate	delineate	VB	VB	_	17	xcomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	sequences	sequence	NNS	NNS	_	19	dobj	_	_
22	responsible	responsible	JJ	JJ	_	21	amod	_	_
23	for	for	IN	IN	_	27	case	_	_
24	both	both	CC	CC	_	27	cc:preconj	_	_
25	the	the	DT	DT	_	27	det	_	_
26	ligand-induced	ligand-induced	JJ	JJ	_	27	amod	_	_
27	phosphorylation	phosphorylation	NN	NN	_	22	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	degradation	degradation	NN	NN	_	27	conj	_	_
31	of	of	IN	IN	_	35	case	_	_
32	I	i	NN	NN	_	35	compound	_	_
33	kappa	kappa	NN	NN	_	35	compound	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	deletion	deletion	NN	NN	_	22	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	C	c	NN	NN	_	9	compound	_	_
9	terminus	terminus	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	I	i	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	9	nmod	_	_
17	up	up	RB	RB	_	20	advmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	amino	amino	NN	NN	_	20	compound	_	_
20	acid	acid	NN	NN	_	5	nmod	_	_
21	279	279	CD	CD	_	20	nummod	_	_
22	abolishes	abolish	VBZ	VBZ	_	3	ccomp	_	_
23	constitutive	constitutive	JJ	JJ	_	22	dobj	_	_
24	but	but	CC	CC	_	23	cc	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	ligand-inducible	ligand-inducible	JJ	JJ	_	23	conj	_	_
27	phosphorylation	phosphorylation	NN	NN	_	23	dep	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	inhibits	inhibit	VBZ	VBZ	_	22	conj	_	_
30	ligand-inducible	ligand-inducible	JJ	JJ	_	31	amod	_	_
31	degradation	degradation	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	3	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	reveals	reveal	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inducible	inducible	JJ	JJ	_	7	amod	_	_
7	phosphorylation	phosphorylation	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	I	i	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	7	nmod	_	_
13	maps	map	VBZ	VBZ	_	3	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	two	two	CD	CD	_	16	nummod	_	_
16	serines	serine	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	N	n	NN	NN	_	20	compound	_	_
20	terminus	terminus	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	residues	residue	NNS	NNS	_	16	dep	_	_
26	32	32	CD	CD	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	36	36	CD	CD	_	26	conj	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	and	and	CC	CC	_	13	cc	_	_
31	that	that	IN	IN	_	38	mark	_	_
32	the	the	DT	DT	_	33	det	_	_
33	mutation	mutation	NN	NN	_	38	nsubj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	either	either	DT	DT	_	36	det	_	_
36	residue	residue	NN	NN	_	33	nmod	_	_
37	is	be	VBZ	VBZ	_	38	cop	_	_
38	sufficient	sufficient	JJ	JJ	_	13	conj	_	_
39	to	to	TO	TO	_	40	mark	_	_
40	abolish	abolish	VB	VB	_	38	xcomp	_	_
41	ligand-induced	ligand-induced	JJ	JJ	_	42	amod	_	_
42	degradation	degradation	NN	NN	_	40	dobj	_	_
43	,	,	,	,	_	3	punct	_	_
44	whereas	whereas	IN	IN	_	46	mark	_	_
45	both	both	DT	DT	_	46	det	_	_
46	residues	residue	NNS	NNS	_	3	advcl	_	_
47	must	must	MD	MD	_	49	aux	_	_
48	be	be	VB	VB	_	49	auxpass	_	_
49	mutated	mutate	VBN	VBN	_	46	dep	_	_
50	to	to	TO	TO	_	51	mark	_	_
51	abolish	abolish	VB	VB	_	49	xcomp	_	_
52	inducible	inducible	JJ	JJ	_	53	amod	_	_
53	phosphorylation	phosphorylation	NN	NN	_	51	dobj	_	_
54	of	of	IN	IN	_	56	case	_	_
55	the	the	DT	DT	_	56	det	_	_
56	protein	protein	NN	NN	_	53	nmod	_	_
57	.	.	.	.	_	3	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	250	250	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	repression	repression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	vitamin	vitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	2	nmod	_	_
10	:	:	:	:	_	2	punct	_	_
11	direct	direct	JJ	JJ	_	12	amod	_	_
12	inhibition	inhibition	NN	NN	_	2	dep	_	_
13	of	of	IN	IN	_	17	case	_	_
14	NFATp	nfatp	NN	NN	_	15	compound	_	_
15	/AP-1	/ap-1	NN	NN	_	17	compound	_	_
16	complex	complex	JJ	JJ	_	15	amod	_	_
17	formation	formation	NN	NN	_	12	nmod	_	_
18	by	by	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
21	hormone	hormone	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	T-lymphocyte	t-lymphocyte	NN	NN	_	2	compound	_	_
2	proliferation	proliferation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	suppressed	suppress	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
7	D3	d3	NN	NN	_	9	compound	_	_
8	-LSB-	-lsb-	-LRB-	-LRB-	_	9	punct	_	_
9	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	nmod	_	_
10	-RSB-	-rsb-	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	9	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	active	active	JJ	JJ	_	14	amod	_	_
14	metabolite	metabolite	NN	NN	_	9	appos	_	_
15	of	of	IN	IN	_	17	case	_	_
16	vitamin	vitamin	NN	NN	_	17	compound	_	_
17	D3	d3	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	associated	associate	VBN	VBN	_	4	conj	_	_
22	with	with	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	decrease	decrease	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	interleukin	interleukin	NN	NN	_	24	nmod	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	IL-2	il-2	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	26	punct	_	_
32	gamma	gamma	NN	NN	_	33	compound	_	_
33	interferon	interferon	NN	NN	_	26	conj	_	_
34	,	,	,	,	_	26	punct	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	39	amod	_	_
37	colony-stimulating	colony-stimulating	JJ	JJ	_	39	amod	_	_
38	factor	factor	NN	NN	_	39	compound	_	_
39	mRNA	mrna	NN	NN	_	26	conj	_	_
40	levels	level	NNS	NNS	_	26	dep	_	_
41	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	1,25(OH)2D3-mediated	1,25(oh)2d3-mediated	JJ	JJ	_	6	amod	_	_
6	repression	repression	NN	NN	_	12	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	Jurkat	jurkat	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	cycloheximide	cycloheximide	NN	NN	_	12	nmod:npmod	_	_
12	resistant	resistant	JJ	JJ	_	2	ccomp	_	_
13	,	,	,	,	_	12	punct	_	_
14	suggesting	suggest	VBG	VBG	_	12	xcomp	_	_
15	that	that	IN	IN	_	22	mark	_	_
16	it	it	PRP	PRP	_	22	nsubj	_	_
17	is	be	VBZ	VBZ	_	22	cop	_	_
18	a	a	DT	DT	_	22	det	_	_
19	direct	direct	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	repressive	repressive	JJ	JJ	_	22	amod	_	_
22	effect	effect	NN	NN	_	14	ccomp	_	_
23	on	on	IN	IN	_	25	case	_	_
24	IL-2	il-2	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	by	by	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	vitamin	vitamin	NN	NN	_	30	compound	_	_
29	D3	d3	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	25	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	VDR	vdr	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	vitamin	vitamin	NN	NN	_	6	compound	_	_
5	D3-mediated	d3-mediated	JJ	JJ	_	6	amod	_	_
6	repression	repression	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	cotransfecting	cotransfect	VBG	VBG	_	3	nmod	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	12	dobj	_	_
15	with	with	IN	IN	_	19	case	_	_
16	IL-2	il-2	NN	NN	_	19	compound	_	_
17	promoter	promoter	NN	NN	_	19	compound	_	_
18	/reporter	/reporter	NN	NN	_	19	compound	_	_
19	constructs	construct	NNS	NNS	_	12	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	a	a	DT	DT	_	24	det	_	_
22	VDR	vdr	NN	NN	_	24	compound	_	_
23	overexpression	overexpression	NN	NN	_	24	compound	_	_
24	vector	vector	NN	NN	_	19	conj	_	_
25	and	and	CC	CC	_	12	cc	_	_
26	by	by	IN	IN	_	28	case	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	12	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	delineated	delineate	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	element	element	NN	NN	_	2	dobj	_	_
5	conferring	confer	VBG	VBG	_	4	acl	_	_
6	both	both	CC	CC	_	8	dep	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	5	dobj	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	receptor	receptor	NN	NN	_	8	nmod	_	_
12	in	in	FW	FW	_	11	amod	_	_
13	vitro	vitro	FW	FW	_	12	dep	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	1,25(OH)2D3-mediated	1,25(oh)2d3-mediated	JJ	JJ	_	16	amod	_	_
16	repression	repression	NN	NN	_	11	conj	_	_
17	in	in	FW	FW	_	16	amod	_	_
18	vivo	vivo	FW	FW	_	17	dep	_	_
19	to	to	TO	TO	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	short	short	JJ	JJ	_	23	amod	_	_
22	40-bp	40-bp	JJ	JJ	_	23	amod	_	_
23	region	region	NN	NN	_	5	nmod	_	_
24	encompassing	encompass	VBG	VBG	_	23	acl	_	_
25	an	a	DT	DT	_	29	det	_	_
26	important	important	JJ	JJ	_	29	amod	_	_
27	positive	positive	JJ	JJ	_	29	amod	_	_
28	regulatory	regulatory	JJ	JJ	_	29	amod	_	_
29	element	element	NN	NN	_	24	dobj	_	_
30	,	,	,	,	_	29	punct	_	_
31	NF-AT-1	nf-at-1	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	29	punct	_	_
33	which	which	WDT	WDT	_	35	nsubjpass	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	bound	bind	VBN	VBN	_	29	acl:relcl	_	_
36	by	by	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	T-cell-specific	t-cell-specific	JJ	JJ	_	40	amod	_	_
39	transcription	transcription	NN	NN	_	40	compound	_	_
40	factor	factor	NN	NN	_	35	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	NFATp	nfatp	NN	NN	_	40	appos	_	_
43	,	,	,	,	_	40	punct	_	_
44	as	as	RB	RB	_	40	cc	_	_
45	well	well	RB	RB	_	44	mwe	_	_
46	as	as	IN	IN	_	44	mwe	_	_
47	by	by	IN	IN	_	48	case	_	_
48	AP-1	ap-1	NN	NN	_	40	conj	_	_
49	.	.	.	.	_	2	punct	_	_

1	VDR	vdr	NN	NN	_	3	compound	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	mutants	mutant	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	unable	unable	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	either	either	RB	RB	_	8	advmod	_	_
8	bind	bind	VB	VB	_	5	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	element	element	NN	NN	_	8	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	11	advmod	_	_
14	or	or	CC	CC	_	8	cc	_	_
15	repress	repress	VB	VB	_	8	conj	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vivo	vivo	FW	FW	_	15	advmod	_	_
18	;	;	:	:	_	5	punct	_	_
19	the	the	DT	DT	_	22	det	_	_
20	VDR	vdr	NN	NN	_	22	compound	_	_
21	DNA-binding	dna-binding	JJ	JJ	_	22	amod	_	_
22	domain	domain	NN	NN	_	27	nsubj	_	_
23	alone	alone	RB	RB	_	22	advmod	_	_
24	,	,	,	,	_	22	punct	_	_
25	however	however	RB	RB	_	27	advmod	_	_
26	,	,	,	,	_	27	punct	_	_
27	bound	bind	VBD	VBD	_	5	parataxis	_	_
28	the	the	DT	DT	_	29	det	_	_
29	element	element	NN	NN	_	27	dobj	_	_
30	but	but	CC	CC	_	27	cc	_	_
31	also	also	RB	RB	_	34	advmod	_	_
32	could	could	MD	MD	_	34	aux	_	_
33	not	not	RB	RB	_	34	neg	_	_
34	repress	repress	VB	VB	_	27	conj	_	_
35	IL-2	il-2	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	10	nsubj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	VDR	vdr	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	mediate	mediate	VB	VB	_	10	xcomp	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	repression	repression	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	combining	combine	VBG	VBG	_	10	advcl	_	_
3	partially	partially	RB	RB	_	5	advmod	_	_
4	purified	purify	VBN	VBN	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	2	dobj	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	2	advmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	observed	observe	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	loss	loss	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	bound	bind	VBN	VBN	_	18	amod	_	_
16	NFATp	nfatp	NN	NN	_	18	compound	_	_
17	/AP-1-DNA	/ap-1-dna	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	12	nmod	_	_
19	upon	upon	IN	IN	_	20	case	_	_
20	inclusion	inclusion	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	VDR	vdr	NN	NN	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	VDR-retinoid	vdr-retinoid	NN	NN	_	26	compound	_	_
25	X	x	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	10	punct	_	_

1	Order	order	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	addition	addition	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	off-rate	off-rate	JJ	JJ	_	1	conj	_	_
6	experiments	experiment	NNS	NNS	_	1	dep	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	the	the	DT	DT	_	13	det	_	_
10	VDR-retinoid	vdr-retinoid	NN	NN	_	13	compound	_	_
11	X	x	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	heterodimer	heterodimer	NN	NN	_	14	nsubj	_	_
14	blocks	block	VBZ	VBZ	_	7	ccomp	_	_
15	NFATp	nfatp	NN	NN	_	17	compound	_	_
16	/AP-1	/ap-1	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	18	compound	_	_
18	formation	formation	NN	NN	_	14	dobj	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	then	then	RB	RB	_	14	advmod	_	_
21	stably	stably	RB	RB	_	14	advmod	_	_
22	associates	associate	VBZ	VBZ	_	14	dep	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	NF-AT-1	nf-at-1	NN	NN	_	26	compound	_	_
26	element	element	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	direct	direct	JJ	JJ	_	3	amod	_	_
3	inhibition	inhibition	NN	NN	_	17	nsubj	_	_
4	by	by	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	hormone	hormone	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activators	activator	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	provide	provide	VB	VB	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	mechanistic	mechanistic	JJ	JJ	_	20	amod	_	_
20	explanation	explanation	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	26	mark	_	_
22	how	how	WRB	WRB	_	26	advmod	_	_
23	vitamin	vitamin	NN	NN	_	24	compound	_	_
24	derivatives	derivative	NNS	NNS	_	26	nsubj	_	_
25	can	can	MD	MD	_	26	aux	_	_
26	act	act	VB	VB	_	20	acl	_	_
27	as	as	IN	IN	_	30	case	_	_
28	potent	potent	JJ	JJ	_	30	amod	_	_
29	immunosuppressive	immunosuppressive	JJ	JJ	_	30	amod	_	_
30	agents	agent	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	PU.1	pu.1	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Spi-1	spi-1	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	1	conj	_	_
8	regulate	regulate	VBP	VBP	_	0	root	_	_
9	expression	expression	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	17	amod	_	_
13	colony-stimulating	colony-stimulating	JJ	JJ	_	17	amod	_	_
14	factor	factor	NN	NN	_	17	compound	_	_
15	receptor	receptor	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Growth	growth	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	important	important	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	hematopoiesis	hematopoiesis	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	5	mark	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	understand	understand	VB	VB	_	19	advcl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanisms	mechanism	NNS	NNS	_	5	dobj	_	_
8	directing	direct	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	these	these	DT	DT	_	14	det	_	_
13	key	key	JJ	JJ	_	14	amod	_	_
14	regulators	regulator	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	hematopoiesis	hematopoiesis	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	initiated	initiate	VBD	VBD	_	0	root	_	_
20	a	a	DT	DT	_	21	det	_	_
21	study	study	NN	NN	_	19	dobj	_	_
22	investigating	investigate	VBG	VBG	_	21	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	22	dobj	_	_
26	activating	activate	VBG	VBG	_	25	acl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	39	case	_	_
30	the	the	DT	DT	_	39	det	_	_
31	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	39	amod	_	_
32	colony-stimulating	colony-stimulating	JJ	JJ	_	39	amod	_	_
33	factor	factor	NN	NN	_	39	compound	_	_
34	(	(	-LRB-	-LRB-	_	39	punct	_	_
35	GM-CSF	gm-csf	NN	NN	_	39	compound	_	_
36	)	)	-RRB-	-RRB-	_	39	punct	_	_
37	receptor	receptor	NN	NN	_	39	compound	_	_
38	alpha	alpha	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	28	nmod	_	_
40	.	.	.	.	_	19	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	11	det	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	GM-CSF	gm-csf	NN	NN	_	11	compound	_	_
9	receptor	receptor	NN	NN	_	11	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	nsubj	_	_
12	directs	direct	VBZ	VBZ	_	4	ccomp	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	tissue-specific	tissue-specific	JJ	JJ	_	19	amod	_	_
19	fashion	fashion	NN	NN	_	12	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	myelomonocytic	myelomonocytic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	12	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	correlates	correlate	VBZ	VBZ	_	22	acl:relcl	_	_
26	with	with	IN	IN	_	29	case	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	expression	expression	NN	NN	_	29	compound	_	_
29	pattern	pattern	NN	NN	_	25	nmod	_	_
30	as	as	IN	IN	_	31	mark	_	_
31	analyzed	analyze	VBN	VBN	_	25	advcl	_	_
32	by	by	IN	IN	_	35	case	_	_
33	reverse	reverse	NN	NN	_	35	compound	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	PCR	pcr	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	GM-CSF	gm-csf	NN	NN	_	5	compound	_	_
3	receptor	receptor	NN	NN	_	5	compound	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	contains	contain	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	10	det	_	_
8	important	important	JJ	JJ	_	10	amod	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	site	site	NN	NN	_	6	dobj	_	_
11	between	between	IN	IN	_	12	case	_	_
12	positions	position	NNS	NNS	_	10	nmod	_	_
13	-53	-53	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-41	-41	CD	CD	_	13	conj	_	_
16	as	as	IN	IN	_	17	mark	_	_
17	identified	identify	VBN	VBN	_	6	advcl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	deletion	deletion	NN	NN	_	20	compound	_	_
20	analysis	analysis	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	constructs	construct	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	myeloid	myeloid	JJ	JJ	_	12	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	B	b	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	5	conj	_	_
11	PU.1	pu.1	NN	NN	_	5	dep	_	_
12	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
13	specifically	specifically	RB	RB	_	16	advmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	CCAAT	ccaat	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	21	nsubjpass	_	_
9	located	located	JJ	JJ	_	8	amod	_	_
10	upstream	upstream	RB	RB	_	9	advmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	PU.1	pu.1	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	10	nmod	_	_
15	between	between	IN	IN	_	16	case	_	_
16	positions	position	NNS	NNS	_	14	nmod	_	_
17	-70	-70	CD	CD	_	16	nummod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	-54	-54	CD	CD	_	17	conj	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	involved	involve	VBN	VBN	_	4	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	positive-negative	positive-negative	JJ	JJ	_	24	amod	_	_
24	regulation	regulation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	GM-CSF	gm-csf	NN	NN	_	30	compound	_	_
28	receptor	receptor	NN	NN	_	30	compound	_	_
29	alpha	alpha	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	11	nsubj	_	_
3	is	be	VBZ	VBZ	_	11	cop	_	_
4	the	the	DT	DT	_	11	det	_	_
5	major	major	JJ	JJ	_	11	amod	_	_
6	CCAAT/enhancer-binding	ccaat/enhancer-binding	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	C/EBP	c/ebp	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	form	form	NN	NN	_	0	root	_	_
12	binding	bind	VBG	VBG	_	11	acl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	site	site	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	12	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	U937	u937	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	Point	point	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	20	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	either	either	CC	CC	_	7	cc:preconj	_	_
5	the	the	DT	DT	_	7	det	_	_
6	PU.1	pu.1	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	2	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	C/EBP	c/ebp	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	conj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	abolish	abolish	VBP	VBP	_	7	acl:relcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	respective	respective	JJ	JJ	_	19	amod	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	result	result	VBP	VBP	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	significant	significant	JJ	JJ	_	24	amod	_	_
24	decrease	decrease	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	30	case	_	_
26	GM-CSF	gm-csf	NN	NN	_	29	compound	_	_
27	receptor	receptor	NN	NN	_	29	compound	_	_
28	alpha	alpha	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	24	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	myelomonocytic	myelomonocytic	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	24	nmod	_	_
34	only	only	RB	RB	_	33	advmod	_	_
35	.	.	.	.	_	20	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	in	in	IN	IN	_	7	case	_	_
7	myeloid	myeloid	JJ	JJ	_	14	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	B	b	NN	NN	_	7	conj	_	_
10	cell	cell	NN	NN	_	7	dep	_	_
11	extracts	extract	VBZ	VBZ	_	10	dep	_	_
12	,	,	,	,	_	14	punct	_	_
13	PU.1	pu.1	NN	NN	_	14	nsubj	_	_
14	forms	form	VBZ	VBZ	_	4	ccomp	_	_
15	a	a	DT	DT	_	23	det	_	_
16	novel	novel	JJ	JJ	_	23	amod	_	_
17	,	,	,	,	_	16	punct	_	_
18	specific	specific	JJ	JJ	_	16	dep	_	_
19	,	,	,	,	_	16	punct	_	_
20	more	more	RBR	RBR	_	22	advmod	_	_
21	slowly	slowly	RB	RB	_	22	advmod	_	_
22	migrating	migrate	VBG	VBG	_	16	dep	_	_
23	complex	complex	NN	NN	_	14	dobj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PU-SF	pu-sf	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	when	when	WRB	WRB	_	28	advmod	_	_
28	binding	bind	VBG	VBG	_	14	advcl	_	_
29	the	the	DT	DT	_	33	det	_	_
30	GM-CSF	gm-csf	NN	NN	_	32	compound	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	33	compound	_	_
33	promoter	promoter	NN	NN	_	28	dobj	_	_
34	PU.1	pu.1	NN	NN	_	35	compound	_	_
35	site	site	NN	NN	_	33	dep	_	_
36	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	demonstration	demonstration	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	interaction	interaction	NN	NN	_	5	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	PU.1	pu.1	NN	NN	_	9	nmod	_	_
12	on	on	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
15	PU.1	pu.1	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	distinct	distinct	JJ	JJ	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	that	that	DT	DT	_	5	nmod	_	_
8	described	describe	VBN	VBN	_	7	acl	_	_
9	previously	previously	RB	RB	_	8	advmod	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	binding	bind	VBG	VBG	_	8	advcl	_	_
12	to	to	TO	TO	_	16	case	_	_
13	B	b	NN	NN	_	16	compound	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	enhancer	enhancer	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	formed	form	VBN	VBN	_	5	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	addition	addition	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	PU.1	pu.1	NN	NN	_	22	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	extracts	extract	NNS	NNS	_	22	nmod	_	_
27	from	from	IN	IN	_	31	case	_	_
28	certain	certain	JJ	JJ	_	31	amod	_	_
29	nonmyeloid	nonmyeloid	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	types	type	NNS	NNS	_	26	nmod	_	_
32	which	which	WDT	WDT	_	35	nsubj	_	_
33	do	do	VBP	VBP	_	35	aux	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	express	express	VB	VB	_	31	acl:relcl	_	_
36	PU.1	pu.1	NN	NN	_	35	dobj	_	_
37	,	,	,	,	_	31	punct	_	_
38	including	include	VBG	VBG	_	40	case	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	31	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	epithelial	epithelial	JJ	JJ	_	43	amod	_	_
43	cells	cell	NNS	NNS	_	40	conj	_	_
44	,	,	,	,	_	31	punct	_	_
45	but	but	CC	CC	_	31	cc	_	_
46	not	not	RB	RB	_	49	neg	_	_
47	from	from	IN	IN	_	49	case	_	_
48	erythroid	erythroid	JJ	JJ	_	49	amod	_	_
49	cells	cell	NNS	NNS	_	31	conj	_	_
50	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	PU-SF	pu-sf	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	4	dep	_	_
10	to	to	TO	TO	_	12	case	_	_
11	PU.1	pu.1	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	9	nmod	_	_
13	found	find	VBN	VBN	_	12	acl	_	_
14	on	on	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	number	number	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
19	promoters	promoter	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	formation	formation	NN	NN	_	24	nsubj	_	_
24	requires	require	VBZ	VBZ	_	9	conj	_	_
25	an	a	DT	DT	_	28	det	_	_
26	intact	intact	JJ	JJ	_	28	amod	_	_
27	PU.1	pu.1	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	24	dobj	_	_
29	adjacent	adjacent	JJ	JJ	_	28	amod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	single-stranded	single-stranded	JJ	JJ	_	33	amod	_	_
33	region	region	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PU.1	pu.1	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	nonmyeloid	nonmyeloid	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	activate	activate	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	13	det	_	_
10	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	alpha	alpha	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	8	dobj	_	_
14	.	.	.	.	_	8	punct	_	_

1	Deletion	deletion	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	amino-terminal	amino-terminal	JJ	JJ	_	5	amod	_	_
5	region	region	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PU.1	pu.1	NN	NN	_	5	nmod	_	_
8	results	result	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	failure	failure	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	form	form	VB	VB	_	11	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	PU-SF	pu-sf	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	concomitant	concomitant	JJ	JJ	_	21	amod	_	_
21	loss	loss	NN	NN	_	11	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	transactivation	transactivation	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	8	punct	_	_
25	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
26	that	that	IN	IN	_	35	mark	_	_
27	formation	formation	NN	NN	_	35	nsubj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	PU-SF	pu-sf	NN	NN	_	31	compound	_	_
31	complex	complex	NN	NN	_	27	nmod	_	_
32	is	be	VBZ	VBZ	_	35	cop	_	_
33	of	of	IN	IN	_	35	case	_	_
34	functional	functional	JJ	JJ	_	35	amod	_	_
35	importance	importance	NN	NN	_	25	ccomp	_	_
36	for	for	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	activity	activity	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	44	case	_	_
40	the	the	DT	DT	_	44	det	_	_
41	GM-CSF	gm-csf	NN	NN	_	44	compound	_	_
42	receptor	receptor	NN	NN	_	44	compound	_	_
43	alpha	alpha	NN	NN	_	44	compound	_	_
44	promoter	promoter	NN	NN	_	38	nmod	_	_
45	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	10	nsubj	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	active	active	JJ	JJ	_	4	ccomp	_	_
11	the	the	DT	DT	_	15	det	_	_
12	GM-CSF	gm-csf	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	10	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	nonmyeloid	nonmyeloid	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	ABSTRACT	abstract	NN	NN	_	0	root	_	_
3	TRUNCATED	truncate	VBN	VBN	_	2	acl	_	_
4	AT	at	IN	IN	_	6	case	_	_
5	400	400	CD	CD	_	6	nummod	_	_
6	WORDS	word	NNS	NNS	_	3	nmod	_	_
7	)	)	-RRB-	-RRB-	_	2	punct	_	_

1	Expression	expression	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	chemokine	chemokine	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	nmod	_	_
6	BLR2/EBI1	blr2/ebi1	NN	NN	_	5	dep	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	transactivated	transactivate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
12	virus	virus	NN	NN	_	14	compound	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	antigen	antigen	NN	NN	_	9	nmod	_	_
15	2	2	CD	CD	_	14	nummod	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	attempt	attempt	NN	NN	_	27	nmod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	identify	identify	VB	VB	_	3	acl	_	_
6	chemokine	chemokine	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	5	dobj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	related	related	JJ	JJ	_	7	acl:relcl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	Burkitt	burkitt	NN	NN	_	15	nmod:poss	_	_
13	's	's	POS	POS	_	15	case	_	_
14	lymphoma	lymphoma	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	10	nmod	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	BLR1	blr1	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	10	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	activated	activate	VBN	VBN	_	25	amod	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
26	we	we	PRP	PRP	_	27	nsubj	_	_
27	used	use	VBD	VBD	_	0	root	_	_
28	RT-PCR	rt-pcr	NN	NN	_	27	dobj	_	_
29	resulting	result	VBG	VBG	_	28	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	isolation	isolation	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	a	a	DT	DT	_	35	det	_	_
35	cDNA	cdna	NN	NN	_	32	nmod	_	_
36	encoding	encode	VBG	VBG	_	35	acl	_	_
37	a	a	DT	DT	_	40	det	_	_
38	seven	seven	CD	CD	_	40	nummod	_	_
39	transmembrane	transmembrane	NN	NN	_	40	compound	_	_
40	receptor	receptor	NN	NN	_	36	dobj	_	_
41	termed	term	VBN	VBN	_	40	acl	_	_
42	BLR2	blr2	NN	NN	_	41	xcomp	_	_
43	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	sequence	sequence	NN	NN	_	6	compound	_	_
6	similarities	similarity	NNS	NNS	_	3	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	family	family	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	G-protein	g-protein	NN	NN	_	14	compound	_	_
12	coupled	coupled	JJ	JJ	_	14	amod	_	_
13	chemokine	chemokine	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	turned	turn	VBD	VBD	_	3	conj	_	_
17	out	out	RP	RP	_	16	compound:prt	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	identical	identical	JJ	JJ	_	16	xcomp	_	_
21	to	to	TO	TO	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	recently	recently	RB	RB	_	24	advmod	_	_
24	described	describe	VBN	VBN	_	26	amod	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	EBI1	ebi1	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	BLR2	blr2	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	11	nsubjpass	_	_
8	could	could	MD	MD	_	11	aux	_	_
9	be	be	VB	VB	_	11	auxpass	_	_
10	highly	highly	RB	RB	_	11	advmod	_	_
11	stimulated	stimulate	VBN	VBN	_	4	ccomp	_	_
12	in	in	IN	IN	_	13	case	_	_
13	mitogen-	mitogen-	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	anti-CD3-treated	anti-cd3-treated	JJ	JJ	_	13	conj	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	13	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	BLR2-specific	blr2-specific	JJ	JJ	_	2	amod	_	_
2	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
3	could	could	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	13	case	_	_
7	all	all	DT	DT	_	13	det	_	_
8	Epstein-Barr	epstein-barr	JJ	JJ	_	13	amod	_	_
9	virus	virus	NN	NN	_	13	compound	_	_
10	positive	positive	JJ	JJ	_	13	amod	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	5	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	transcription	transcription	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	BLR2	blr2	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	could	could	MD	MD	_	12	aux	_	_
10	be	be	VB	VB	_	12	auxpass	_	_
11	specifically	specifically	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	2	ccomp	_	_
13	in	in	IN	IN	_	19	case	_	_
14	Epstein-Barr	epstein-barr	JJ	JJ	_	19	amod	_	_
15	virus	virus	NN	NN	_	19	compound	_	_
16	negative	negative	JJ	JJ	_	19	amod	_	_
17	BL	bl	NN	NN	_	19	compound	_	_
18	41	41	CD	CD	_	19	nummod	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	via	via	IN	IN	_	22	case	_	_
21	estrogen-mediated	estrogen-mediated	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	12	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	Epstein-Barr	epstein-barr	JJ	JJ	_	27	amod	_	_
25	virus	virus	NN	NN	_	27	compound	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	antigen	antigen	NN	NN	_	22	nmod	_	_
28	2	2	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	27	punct	_	_
30	a	a	DT	DT	_	32	det	_	_
31	key	key	JJ	JJ	_	32	amod	_	_
32	regulator	regulator	NN	NN	_	27	appos	_	_
33	of	of	IN	IN	_	37	case	_	_
34	viral	viral	JJ	JJ	_	37	amod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	cellular	cellular	JJ	JJ	_	34	conj	_	_
37	genes	gene	NNS	NNS	_	32	nmod	_	_
38	in	in	IN	IN	_	41	case	_	_
39	immortalized	immortalize	VBN	VBN	_	41	amod	_	_
40	B	b	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	32	nmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	BLR2	blr2	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	migration	migration	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	activated	activate	VBN	VBN	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	in	in	IN	IN	_	19	case	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	pathogenesis	pathogenesis	NN	NN	_	10	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	TCF-1	tcf-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	nsubj	_	_
5	encodes	encode	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	5	dobj	_	_
10	uniquely	uniquely	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	9	acl	_	_
12	in	in	IN	IN	_	13	case	_	_
13	normal	normal	JJ	JJ	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	neoplastic	neoplastic	JJ	JJ	_	13	conj	_	_
16	T-lineage	t-lineage	JJ	JJ	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	dep	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TCF-1	tcf-1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	putative	putative	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	4	dobj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	affinity	affinity	NN	NN	_	8	nmod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	sequence	sequence	NN	NN	_	14	compound	_	_
14	motif	motif	NN	NN	_	10	nmod	_	_
15	occurring	occur	VBG	VBG	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	number	number	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	enhancers	enhancer	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	originally	originally	RB	RB	_	5	advmod	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	5	xcomp	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell-specific	cell-specific	JJ	JJ	_	13	amod	_	_
13	fashion	fashion	NN	NN	_	8	nmod	_	_
14	within	within	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	set	set	NN	NN	_	8	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	mouse	mouse	NN	NN	_	18	conj	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	expression	expression	NN	NN	_	6	nsubj	_	_
5	reportedly	reportedly	RB	RB	_	6	advmod	_	_
6	occurs	occur	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	multiple	multiple	JJ	JJ	_	10	amod	_	_
9	nonlymphoid	nonlymphoid	JJ	JJ	_	10	amod	_	_
10	tissues	tissue	NNS	NNS	_	6	nmod	_	_
11	during	during	IN	IN	_	13	case	_	_
12	murine	murine	JJ	JJ	_	13	amod	_	_
13	embryogenesis	embryogenesis	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	raised	raise	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	antibody	antibody	NN	NN	_	4	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	document	document	VB	VB	_	4	xcomp	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	biochemistry	biochemistry	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	TCF-1	tcf-1	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	8	advcl	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TCF-1	tcf-1	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	detectable	detectable	JJ	JJ	_	0	root	_	_
9	only	only	RB	RB	_	15	advmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	cell	cell	NN	NN	_	15	compound	_	_
12	lines	line	NNS	NNS	_	15	compound	_	_
13	of	of	IN	IN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lineage	lineage	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	always	always	RB	RB	_	5	advmod	_	_
5	restricted	restricted	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nucleus	nucleus	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	Immunohistochemistry	immunohistochemistry	NN	NN	_	8	nsubj	_	_
2	on	on	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	panel	panel	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	4	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TCF-1	tcf-1	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	8	ccomp	_	_
15	exclusively	exclusively	RB	RB	_	14	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	thymocytes	thymocyte	NNS	NNS	_	15	nmod	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	in	in	IN	IN	_	22	case	_	_
20	CD3+	cd3+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
25	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
26	tissues	tissue	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Western	western	NN	NN	_	2	compound	_	_
2	blotting	blotting	NN	NN	_	3	nsubj	_	_
3	yielded	yield	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	set	set	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	bands	band	NNS	NNS	_	5	nmod	_	_
8	ranging	range	VBG	VBG	_	7	acl	_	_
9	from	from	IN	IN	_	11	case	_	_
10	25	25	CD	CD	_	11	nummod	_	_
11	kD	kd	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	55	55	CD	CD	_	14	nummod	_	_
14	kD	kd	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	resulting	result	VBG	VBG	_	3	advcl	_	_
17	from	from	IN	IN	_	20	case	_	_
18	extensive	extensive	JJ	JJ	_	20	amod	_	_
19	alternative	alternative	JJ	JJ	_	20	amod	_	_
20	splicing	splicing	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TCF-1	tcf-1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	detectable	detectable	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	all	all	DT	DT	_	8	det	_	_
8	samples	sample	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	set	set	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	22	22	CD	CD	_	15	nummod	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	malignancies	malignancy	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	various	various	JJ	JJ	_	18	amod	_	_
18	stages	stage	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	maturation	maturation	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	but	but	CC	CC	_	5	cc	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	absent	absent	JJ	JJ	_	5	conj	_	_
25	from	from	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	large	large	JJ	JJ	_	28	amod	_	_
28	number	number	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	other	other	JJ	JJ	_	32	amod	_	_
31	hematologic	hematologic	JJ	JJ	_	32	amod	_	_
32	neoplasms	neoplasm	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
7	function	function	NN	NN	_	3	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	TCF-1	tcf-1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	notion	notion	NN	NN	_	3	dep	_	_
13	corroborated	corroborate	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	recent	recent	JJ	JJ	_	16	amod	_	_
16	observations	observation	NNS	NNS	_	13	nmod	_	_
17	on	on	IN	IN	_	20	case	_	_
18	Tcf-1	tcf-1	NN	NN	_	20	compound	_	_
19	knock-out	knock-out	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
9	TCF-1	tcf-1	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	serve	serve	VB	VB	_	6	ccomp	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	pan-T-lineage	pan-t-lineage	JJ	JJ	_	16	amod	_	_
16	marker	marker	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	diagnosis	diagnosis	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	malignancies	malignancy	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	overexpression	overexpression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	L-selectin	l-selectin	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	fresh	fresh	JJ	JJ	_	10	amod	_	_
9	leukemic	leukemic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	adult	adult	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	leukemia	leukemia	NN	NN	_	10	nmod	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	can	can	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	transactivated	transactivate	VBN	VBN	_	6	acl:relcl	_	_
19	by	by	IN	IN	_	26	case	_	_
20	human	human	JJ	JJ	_	26	amod	_	_
21	T-cell	t-cell	NN	NN	_	26	compound	_	_
22	lymphotropic	lymphotropic	JJ	JJ	_	26	amod	_	_
23	virus	virus	NN	NN	_	26	compound	_	_
24	type	type	NN	NN	_	26	compound	_	_
25	1	1	CD	CD	_	26	nummod	_	_
26	Tax	tax	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	L-selectin	l-selectin	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	an	a	DT	DT	_	5	det	_	_
4	adhesion	adhesion	NN	NN	_	5	compound	_	_
5	molecule	molecule	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	selectin	selectin	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	mediates	mediate	VBZ	VBZ	_	5	acl:relcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	initial	initial	JJ	JJ	_	14	amod	_	_
14	step	step	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	leukocyte	leukocyte	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	vascular	vascular	JJ	JJ	_	20	amod	_	_
20	endothelium	endothelium	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	expression	expression	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	L-selectin	l-selectin	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	downregulated	downregulate	VBN	VBN	_	0	root	_	_
12	at	at	IN	IN	_	15	case	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	protein	protein	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mRNA	mrna	NN	NN	_	15	conj	_	_
18	levels	level	NNS	NNS	_	15	dep	_	_
19	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	leukemic	leukemic	JJ	JJ	_	7	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	infiltration	infiltration	NN	NN	_	4	nmod	_	_
9	into	into	IN	IN	_	10	case	_	_
10	organs	organ	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	studied	study	VBD	VBD	_	2	parataxis	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	regulation	regulation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	L-selectin	l-selectin	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	15	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	fresh	fresh	JJ	JJ	_	24	amod	_	_
23	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	15	nmod	_	_
25	of	of	IN	IN	_	32	case	_	_
26	adult	adult	JJ	JJ	_	28	amod	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	leukemia	leukemia	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	ATL	atl	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	patients	patient	NNS	NNS	_	24	nmod	_	_
33	and	and	CC	CC	_	13	cc	_	_
34	investigated	investigate	VBD	VBD	_	13	conj	_	_
35	the	the	DT	DT	_	36	det	_	_
36	response	response	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	L-selectin	l-selectin	NN	NN	_	40	compound	_	_
40	promoter	promoter	NN	NN	_	36	nmod	_	_
41	to	to	TO	TO	_	51	case	_	_
42	human	human	JJ	JJ	_	51	amod	_	_
43	T-cell	t-cell	NN	NN	_	51	compound	_	_
44	lymphotropic	lymphotropic	JJ	JJ	_	51	amod	_	_
45	virus	virus	NN	NN	_	51	compound	_	_
46	type	type	NN	NN	_	51	compound	_	_
47	1	1	CD	CD	_	51	nummod	_	_
48	(	(	-LRB-	-LRB-	_	51	punct	_	_
49	HTLV-1	htlv-1	NN	NN	_	51	compound	_	_
50	)	)	-RRB-	-RRB-	_	51	punct	_	_
51	Tax	tax	NN	NN	_	36	nmod	_	_
52	,	,	,	,	_	51	punct	_	_
53	which	which	WDT	WDT	_	58	nsubj	_	_
54	is	be	VBZ	VBZ	_	58	cop	_	_
55	a	a	DT	DT	_	58	det	_	_
56	viral	viral	JJ	JJ	_	58	amod	_	_
57	transcriptional	transcriptional	JJ	JJ	_	58	amod	_	_
58	transactivator	transactivator	NN	NN	_	51	acl:relcl	_	_
59	.	.	.	.	_	2	punct	_	_

1	Flow	flow	NN	NN	_	2	compound	_	_
2	cytometry	cytometry	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	L-selectin	l-selectin	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	3	ccomp	_	_
8	on	on	IN	IN	_	11	case	_	_
9	fresh	fresh	JJ	JJ	_	11	amod	_	_
10	ATL	atl	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	along	along	IN	IN	_	11	cc	_	_
13	with	with	IN	IN	_	12	dep	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	antigens	antigen	NNS	NNS	_	11	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	ATL	atl	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	overexpressed	overexpress	VBD	VBD	_	4	ccomp	_	_
9	that	that	DT	DT	_	11	det	_	_
10	L-selectin	l-selectin	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	level	level	NN	NN	_	18	nsubjpass	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	aberrantly	aberrantly	RB	RB	_	18	advmod	_	_
18	upregulated	upregulate	VBN	VBN	_	8	conj	_	_
19	after	after	IN	IN	_	21	case	_	_
20	PMA	pma	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Studies	study	NNS	NNS	_	6	nsubj	_	_
2	using	use	VBG	VBG	_	1	acl	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	situ	situ	FW	FW	_	3	dep	_	_
5	hybridization	hybridization	NN	NN	_	2	dobj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	expression	expression	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	L-selectin	l-selectin	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	infiltrating	infiltrate	VBG	VBG	_	16	amod	_	_
15	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	liver	liver	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	two	two	CD	CD	_	23	nummod	_	_
22	ATL	atl	NN	NN	_	23	compound	_	_
23	patients	patient	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Intravenous	intravenous	JJ	JJ	_	2	amod	_	_
2	injection	injection	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	rat	rat	NN	NN	_	7	compound	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	2	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	overexpresses	overexpress	VBZ	VBZ	_	7	acl:relcl	_	_
10	L-selectin	l-selectin	NN	NN	_	9	dobj	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	increased	increase	VBN	VBN	_	14	amod	_	_
13	organ	organ	NN	NN	_	14	compound	_	_
14	infiltration	infiltration	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Tax	tax	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	JPX9	jpx9	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	14	case	_	_
11	about	about	RB	RB	_	13	advmod	_	_
12	a	a	DT	DT	_	13	det	_	_
13	twofold	twofold	JJ	JJ	_	14	amod	_	_
14	increase	increase	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	mRNA	mrna	NN	NN	_	19	compound	_	_
18	expression	expression	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	14	nmod	_	_
20	compared	compare	VBN	VBN	_	24	case	_	_
21	with	with	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	basal	basal	JJ	JJ	_	24	amod	_	_
24	level	level	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Chloramphenicol	chloramphenicol	NN	NN	_	2	compound	_	_
2	acetyltransferase	acetyltransferase	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CAT	cat	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	assay	assay	NN	NN	_	10	nsubj	_	_
7	after	after	IN	IN	_	9	case	_	_
8	transient	transient	JJ	JJ	_	9	amod	_	_
9	cotransfection	cotransfection	NN	NN	_	6	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	about	about	RB	RB	_	13	advmod	_	_
12	a	a	DT	DT	_	13	det	_	_
13	fivefold	fivefold	JJ	JJ	_	14	amod	_	_
14	transactivation	transactivation	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	L-selectin	l-selectin	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	14	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	Tax	tax	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	serum	serum	NN	NN	_	3	compound	_	_
3	level	level	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	shed	shed	NN	NN	_	7	compound	_	_
7	form	form	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	L-selectin	l-selectin	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	increased	increase	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	ATL	atl	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	mean	mean	NN	NN	_	12	dep	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	SD	sd	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	4,215.4	4,215.4	CD	CD	_	24	nummod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	4,111	4,111	CD	CD	_	21	conj	_	_
24	ng/mL	ng/ml	NN	NN	_	17	appos	_	_
25	)	)	-RRB-	-RRB-	_	17	punct	_	_
26	compared	compare	VBN	VBN	_	28	case	_	_
27	with	with	IN	IN	_	28	case	_	_
28	those	those	DT	DT	_	12	advcl	_	_
29	of	of	IN	IN	_	31	case	_	_
30	asymptomatic	asymptomatic	JJ	JJ	_	31	amod	_	_
31	carriers	carrier	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	healthy	healthy	JJ	JJ	_	35	amod	_	_
34	blood	blood	NN	NN	_	35	compound	_	_
35	donors	donor	NNS	NNS	_	31	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	mean	mean	NN	NN	_	28	dep	_	_
38	+/-	+/-	CC	CC	_	37	cc	_	_
39	SD	sd	NN	NN	_	37	conj	_	_
40	,	,	,	,	_	37	punct	_	_
41	1,148.0	1,148.0	CD	CD	_	44	nummod	_	_
42	+/-	+/-	CC	CC	_	41	cc	_	_
43	269.0	269.0	CD	CD	_	41	conj	_	_
44	ng/mL	ng/ml	NN	NN	_	37	appos	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	991.9	991.9	CD	CD	_	49	nummod	_	_
47	+/-	+/-	CC	CC	_	46	cc	_	_
48	224	224	CD	CD	_	46	conj	_	_
49	ng/mL	ng/ml	NN	NN	_	44	conj	_	_
50	,	,	,	,	_	37	punct	_	_
51	respectively	respectively	RB	RB	_	37	advmod	_	_
52	)	)	-RRB-	-RRB-	_	37	punct	_	_
53	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	ATL	atl	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubj	_	_
7	constitutively	constitutively	RB	RB	_	8	advmod	_	_
8	overexpress	overexpress	VBP	VBP	_	3	ccomp	_	_
9	the	the	DT	DT	_	11	det	_	_
10	L-selectin	l-selectin	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	8	dobj	_	_
12	that	that	WDT	WDT	_	15	nsubjpass	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	transactivated	transactivate	VBN	VBN	_	11	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	HTLV-1	htlv-1	NN	NN	_	15	nmod	_	_
18	Tax	tax	NN	NN	_	17	dep	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	overexpression	overexpression	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	L-selectin	l-selectin	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	as	as	RB	RB	_	4	cc	_	_
7	well	well	RB	RB	_	6	mwe	_	_
8	as	as	IN	IN	_	6	mwe	_	_
9	of	of	IN	IN	_	11	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	cytokines	cytokine	NNS	NNS	_	4	conj	_	_
12	,	,	,	,	_	2	punct	_	_
13	by	by	IN	IN	_	15	case	_	_
14	ATL	atl	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	2	nmod	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	provide	provide	VB	VB	_	0	root	_	_
18	a	a	DT	DT	_	19	det	_	_
19	basis	basis	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	24	mark	_	_
21	ATL	atl	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	24	nsubj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	attach	attach	VB	VB	_	19	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	vascular	vascular	JJ	JJ	_	27	amod	_	_
27	endothelium	endothelium	NN	NN	_	24	dobj	_	_
28	,	,	,	,	_	17	punct	_	_
29	leading	lead	VBG	VBG	_	17	advcl	_	_
30	to	to	TO	TO	_	31	case	_	_
31	transmigration	transmigration	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	organ	organ	NN	NN	_	34	compound	_	_
34	infitration	infitration	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	17	punct	_	_

1	HMG-I	hmg-i	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	GATA	gata	NN	NN	_	5	compound	_	_
5	motifs	motif	NNS	NNS	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	implications	implication	NNS	NNS	_	2	dep	_	_
8	for	for	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	HPFH	hpfh	NN	NN	_	11	compound	_	_
11	syndrome	syndrome	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	binding	binding	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	HMG-I	hmg-i	NN	NN	_	8	dep	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	gamma-globin	gamma-globin	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	HMG-I	hmg-i	NN	NN	_	5	nsubj	_	_
5	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
6	preferentially	preferentially	RB	RB	_	5	advmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	more	more	JJR	JJR	_	5	nmod	_	_
10	3'	3'	JJ	JJ	_	9	amod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	pair	pair	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	GATA	gata	NN	NN	_	16	compound	_	_
16	motifs	motif	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	gamma-globin	gamma-globin	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	;	;	:	:	_	2	punct	_	_
22	this	this	DT	DT	_	24	det	_	_
23	paired	paired	JJ	JJ	_	24	amod	_	_
24	motif	motif	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	bound	bind	VBN	VBN	_	2	parataxis	_	_
27	by	by	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	erythroid	erythroid	JJ	JJ	_	31	amod	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	GATA-1	gata-1	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	naturally	naturally	RB	RB	_	3	advmod	_	_
3	occurring	occur	VBG	VBG	_	4	amod	_	_
4	mutation	mutation	NN	NN	_	15	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	-175	-175	CD	CD	_	7	nummod	_	_
7	T-C	t-c	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	area	area	NN	NN	_	4	nmod	_	_
12	bound	bind	VBN	VBN	_	4	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	HMG-I	hmg-i	NN	NN	_	12	nmod	_	_
15	results	result	VBZ	VBZ	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	overexpression	overexpression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	gamma-globin	gamma-globin	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	adult	adult	JJ	JJ	_	24	amod	_	_
22	red	red	JJ	JJ	_	24	amod	_	_
23	blood	blood	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	17	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HPFH	hpfh	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	up-regulation	up-regulation	NN	NN	_	17	conj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	gamma-globin	gamma-globin	NN	NN	_	33	compound	_	_
33	promoter	promoter	NN	NN	_	29	nmod	_	_
34	in	in	IN	IN	_	38	case	_	_
35	in	in	FW	FW	_	38	amod	_	_
36	vitro	vitro	FW	FW	_	35	dep	_	_
37	expression	expression	NN	NN	_	38	compound	_	_
38	assays	assay	NNS	NNS	_	29	nmod	_	_
39	;	;	:	:	_	15	punct	_	_
40	HMG-I	hmg-i	NN	NN	_	43	nsubj	_	_
41	does	do	VBZ	VBZ	_	43	aux	_	_
42	not	not	RB	RB	_	43	neg	_	_
43	bind	bind	VB	VB	_	15	parataxis	_	_
44	to	to	TO	TO	_	47	case	_	_
45	this	this	DT	DT	_	47	det	_	_
46	mutant	mutant	JJ	JJ	_	47	amod	_	_
47	sequence	sequence	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	survey	survey	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GATA	gata	NN	NN	_	5	compound	_	_
5	motifs	motif	NNS	NNS	_	2	nmod	_	_
6	from	from	IN	IN	_	9	case	_	_
7	other	other	JJ	JJ	_	9	amod	_	_
8	globin	globin	NN	NN	_	9	compound	_	_
9	cis-elements	cis-element	NNS	NNS	_	5	nmod	_	_
10	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
11	HMG-I	hmg-i	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	10	dobj	_	_
13	to	to	TO	TO	_	14	case	_	_
14	most	most	JJS	JJS	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	them	they	PRP	PRP	_	14	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	HMG-I	hmg-i	NN	NN	_	3	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	HPFH	hpfh	NN	NN	_	8	compound	_	_
8	phenotype	phenotype	NN	NN	_	3	nmod	_	_
9	;	;	:	:	_	3	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	speculate	speculate	VBP	VBP	_	3	parataxis	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	it	it	PRP	PRP	_	15	nsubj	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	participate	participate	VB	VB	_	11	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	formation	formation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	multiprotein	multiprotein	JJ	JJ	_	21	amod	_	_
21	complexes	complex	NNS	NNS	_	18	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	regulate	regulate	VBP	VBP	_	21	acl:relcl	_	_
24	globin	globin	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	essential	essential	JJ	JJ	_	4	amod	_	_
4	GATA	gata	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Ets	ets	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	motifs	motif	NNS	NNS	_	4	conj	_	_
9	within	within	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	promoter	promoter	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	platelet	platelet	NN	NN	_	18	compound	_	_
15	glycoprotein	glycoprotein	NN	NN	_	18	compound	_	_
16	Ib	ib	NN	NN	_	18	compound	_	_
17	alpha	alpha	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Platelet	platelet	NN	NN	_	2	compound	_	_
2	glycoprotein	glycoprotein	NN	NN	_	11	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GP	gp	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	Ib-IX-V	ib-ix-v	NN	NN	_	2	dep	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	multisubunit	multisubunit	JJ	JJ	_	11	amod	_	_
10	adhesion	adhesion	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	supports	support	VBZ	VBZ	_	11	acl:relcl	_	_
14	platelet	platelet	NN	NN	_	15	compound	_	_
15	attachment	attachment	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	thrombogenic	thrombogenic	JJ	JJ	_	18	amod	_	_
18	surfaces	surface	NNS	NNS	_	15	nmod	_	_
19	at	at	IN	IN	_	20	case	_	_
20	sites	site	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	vascular	vascular	JJ	JJ	_	23	amod	_	_
23	injury	injury	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	congenital	congenital	JJ	JJ	_	3	amod	_	_
3	absence	absence	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	receptor	receptor	NN	NN	_	3	nmod	_	_
7	results	result	VBZ	VBZ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	bleeding	bleeding	JJ	JJ	_	11	amod	_	_
11	disorder	disorder	NN	NN	_	7	nmod	_	_
12	associated	associate	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	``	``	``	``	_	16	punct	_	_
15	giant	giant	JJ	JJ	_	16	amod	_	_
16	platelets	platelet	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	condition	condition	NN	NN	_	11	appos	_	_
20	linking	link	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	complex	complex	NN	NN	_	22	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	platelet	platelet	NN	NN	_	28	compound	_	_
28	morphogenesis	morphogenesis	NN	NN	_	20	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	0	root	_	_
3	better	better	JJR	JJR	_	5	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	GP	gp	NN	NN	_	10	compound	_	_
9	Ib-IX-V	ib-ix-v	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	studies	study	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	undertaken	undertake	VBN	VBN	_	2	parataxis	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	define	define	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	essential	essential	JJ	JJ	_	20	amod	_	_
19	genetic	genetic	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	16	dobj	_	_
21	supporting	support	VBG	VBG	_	20	acl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	alpha-subunit	alpha-subunit	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	complex	complex	NN	NN	_	26	nmod	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	GP	gp	NN	NN	_	33	compound	_	_
32	Ib	ib	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	26	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	2	punct	_	_

1	GP	gp	NN	NN	_	4	compound	_	_
2	Ib	ib	NN	NN	_	4	compound	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	evaluated	evaluate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	transfection	transfection	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	erythroleukemia	erythroleukemia	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	plasmids	plasmid	NNS	NNS	_	9	nmod	_	_
17	coding	code	VBG	VBG	_	16	acl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	enzyme	enzyme	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	luciferase	luciferase	NN	NN	_	20	appos	_	_
23	.	.	.	.	_	7	punct	_	_

1	Studies	study	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	initiated	initiate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	fragment	fragment	NN	NN	_	3	nmod	_	_
7	extending	extend	VBG	VBG	_	6	acl	_	_
8	2,738	2,738	CD	CD	_	9	nummod	_	_
9	nucleotides	nucleotide	NNS	NNS	_	7	dobj	_	_
10	5'	5'	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	start	start	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	7	nmod	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	lead	lead	VBD	VBD	_	3	conj	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	identification	identification	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	253	253	CD	CD	_	23	nummod	_	_
23	nucleotides	nucleotide	NNS	NNS	_	20	nmod	_	_
24	retaining	retain	VBG	VBG	_	23	acl	_	_
25	full	full	JJ	JJ	_	27	amod	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	erythroleukemia	erythroleukemia	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	24	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	cells	cell	NNS	NNS	_	21	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	nonhematopoietic	nonhematopoietic	JJ	JJ	_	5	amod	_	_
5	lineage	lineage	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	endothelial	endothelial	JJ	JJ	_	2	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	HeLa	hela	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	21	punct	_	_
13	the	the	DT	DT	_	18	det	_	_
14	GP	gp	NN	NN	_	17	compound	_	_
15	Ib	ib	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	21	nsubj	_	_
19	was	be	VBD	VBD	_	21	cop	_	_
20	no	no	RB	RB	_	21	neg	_	_
21	greater	greater	JJR	JJR	_	0	root	_	_
22	than	than	IN	IN	_	24	case	_	_
23	background	background	NN	NN	_	24	compound	_	_
24	levels	level	NNS	NNS	_	21	nmod	_	_
25	obtained	obtain	VBN	VBN	_	24	acl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	promoterless	promoterless	JJ	JJ	_	28	amod	_	_
28	constructs	construct	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	site-directed	site-directed	JJ	JJ	_	7	amod	_	_
6	mutagenesis	mutagenesis	NN	NN	_	7	compound	_	_
7	studies	study	NNS	NNS	_	3	conj	_	_
8	defined	define	VBD	VBD	_	0	root	_	_
9	essential	essential	JJ	JJ	_	10	amod	_	_
10	GATA	gata	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Ets	ets	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	motifs	motif	NNS	NNS	_	10	conj	_	_
15	93	93	CD	CD	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	150	150	CD	CD	_	15	conj	_	_
18	nucleotides	nucleotide	NNS	NNS	_	10	nmod	_	_
19	upstream	upstream	JJ	JJ	_	18	amod	_	_
20	of	of	IN	IN	_	18	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	transcription	transcription	NN	NN	_	24	compound	_	_
23	start	start	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	18	dep	_	_
25	,	,	,	,	_	8	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	finding	finding	NN	NN	_	8	dep	_	_
28	which	which	WDT	WDT	_	30	nsubj	_	_
29	further	further	RB	RB	_	30	advmod	_	_
30	substantiates	substantiate	VBZ	VBZ	_	27	acl:relcl	_	_
31	these	these	DT	DT	_	32	det	_	_
32	elements	element	NNS	NNS	_	30	dobj	_	_
33	as	as	IN	IN	_	35	case	_	_
34	important	important	JJ	JJ	_	35	amod	_	_
35	determinants	determinant	NNS	NNS	_	30	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	megakaryocytic	megakaryocytic	JJ	JJ	_	39	amod	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	define	define	VBP	VBP	_	0	root	_	_
4	essential	essential	JJ	JJ	_	6	amod	_	_
5	cis-acting	cis-acting	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	3	dobj	_	_
7	responsible	responsible	JJ	JJ	_	6	amod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	GP	gp	NN	NN	_	14	compound	_	_
13	Ib	ib	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	provide	provide	VBP	VBP	_	3	conj	_	_
17	insights	insight	NNS	NNS	_	16	dobj	_	_
18	into	into	IN	IN	_	20	case	_	_
19	molecular	molecular	JJ	JJ	_	20	amod	_	_
20	events	event	NNS	NNS	_	17	nmod	_	_
21	coinciding	coincide	VBG	VBG	_	20	acl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	release	release	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	normal	normal	JJ	JJ	_	27	amod	_	_
27	platelets	platelet	NNS	NNS	_	24	nmod	_	_
28	into	into	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	bloodstream	bloodstream	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Nonopsonic	nonopsonic	JJ	JJ	_	2	amod	_	_
2	phagocytosis	phagocytosis	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Pseudomonas	pseudomonas	FW	FW	_	5	compound	_	_
5	aeruginosa	aeruginosa	FW	FW	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	polymorphonuclear	polymorphonuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	7	conj	_	_
11	requires	require	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	bacterial	bacterial	JJ	JJ	_	17	amod	_	_
17	flagellum	flagellum	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Whereas	whereas	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	mechanism	mechanism	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	nonopsonic	nonopsonic	JJ	JJ	_	6	amod	_	_
6	phagocytosis	phagocytosis	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Pseudomonas	pseudomonas	FW	FW	_	9	compound	_	_
9	aeruginosa	aeruginosa	FW	FW	_	6	nmod	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	described	describe	VBN	VBN	_	20	advcl	_	_
13	,	,	,	,	_	20	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	bacterial	bacterial	JJ	JJ	_	16	amod	_	_
16	ligands	ligand	NNS	NNS	_	20	nsubjpass	_	_
17	required	require	VBN	VBN	_	16	acl	_	_
18	are	be	VBP	VBP	_	20	auxpass	_	_
19	poorly	poorly	RB	RB	_	20	advmod	_	_
20	understood	understand	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	requisite	requisite	JJ	JJ	_	6	amod	_	_
5	bacterial	bacterial	JJ	JJ	_	6	amod	_	_
6	ligands	ligand	NNS	NNS	_	2	dobj	_	_
7	,	,	,	,	_	2	punct	_	_
8	studies	study	NNS	NNS	_	27	nsubjpass	_	_
9	with	with	IN	IN	_	11	case	_	_
10	isogenic	isogenic	JJ	JJ	_	11	amod	_	_
11	mutants	mutant	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	P.	p.	FW	FW	_	14	compound	_	_
14	aeruginosa	aeruginosa	FW	FW	_	11	nmod	_	_
15	PAK	pak	NN	NN	_	14	dep	_	_
16	lacking	lack	VBG	VBG	_	14	acl	_	_
17	pili	pilus	NNS	NNS	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	flagella	flagellum	NNS	NNS	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	the	the	DT	DT	_	25	det	_	_
23	RpoN	rpon	NN	NN	_	25	compound	_	_
24	sigma	sigma	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	17	conj	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	undertaken	undertake	VBN	VBN	_	2	parataxis	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	RpoN	rpon	NN	NN	_	3	compound	_	_
3	mutant	mutant	NN	NN	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	lacking	lack	VBG	VBG	_	3	acl	_	_
6	pili	pilus	NNS	NNS	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	flagella	flagellum	NNS	NNS	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	nonpilus	nonpilus	JJ	JJ	_	12	amod	_	_
12	adhesins	adhesin	NNS	NNS	_	6	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	bound	bind	VBD	VBD	_	0	root	_	_
15	poorly	poorly	RB	RB	_	14	advmod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	resistant	resistant	JJ	JJ	_	14	conj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	ingestion	ingestion	NN	NN	_	18	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	both	both	CC	CC	_	23	cc:preconj	_	_
23	macrophages	macrophage	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	neutrophils	neutrophil	NNS	NNS	_	23	conj	_	_
26	.	.	.	.	_	14	punct	_	_

1	Pili	pilus	NNS	NNS	_	5	nsubjpass	_	_
2	were	be	VBD	VBD	_	5	auxpass	_	_
3	not	not	RB	RB	_	5	neg	_	_
4	absolutely	absolutely	RB	RB	_	5	advmod	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	binding	binding	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	phagocytosis	phagocytosis	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	P.	p.	FW	FW	_	12	compound	_	_
12	aeruginosa	aeruginosa	FW	FW	_	7	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	flagellum	flagellum	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	binding	binding	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	P.	p.	FW	FW	_	13	compound	_	_
13	aeruginosa	aeruginosa	FW	FW	_	10	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	macrophages	macrophage	NNS	NNS	_	10	nmod	_	_
16	but	but	CC	CC	_	8	cc	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	critical	critical	JJ	JJ	_	8	conj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	subsequent	subsequent	JJ	JJ	_	22	amod	_	_
22	internalization	internalization	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	bacterium	bacterium	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	8	punct	_	_
27	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
28	that	that	IN	IN	_	40	mark	_	_
29	this	this	DT	DT	_	30	det	_	_
30	factor	factor	NN	NN	_	40	nsubj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	a	a	DT	DT	_	34	det	_	_
33	surface	surface	NN	NN	_	34	compound	_	_
34	ligand	ligand	NN	NN	_	30	conj	_	_
35	associated	associate	VBN	VBN	_	34	acl	_	_
36	with	with	IN	IN	_	38	case	_	_
37	its	its	PRP$	PRP$	_	38	nmod:poss	_	_
38	assembly	assembly	NN	NN	_	35	nmod	_	_
39	was	be	VBD	VBD	_	40	cop	_	_
40	responsible	responsible	JJ	JJ	_	27	ccomp	_	_
41	for	for	IN	IN	_	42	case	_	_
42	stimulation	stimulation	NN	NN	_	40	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	nonopsonic	nonopsonic	JJ	JJ	_	45	amod	_	_
45	phagocytosis	phagocytosis	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	8	punct	_	_

1	Circumvention	circumvention	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	tolerance	tolerance	NN	NN	_	1	nmod	_	_
4	for	for	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	3	nmod	_	_
10	TCF-1	tcf-1	NN	NN	_	9	dep	_	_
11	by	by	IN	IN	_	12	case	_	_
12	immunization	immunization	NN	NN	_	1	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	TCF-1	tcf-1	NN	NN	_	16	compound	_	_
15	knock-out	knock-out	JJ	JJ	_	16	amod	_	_
16	mice	mouse	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	events	event	NNS	NNS	_	15	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	underlie	underlie	VBP	VBP	_	2	acl:relcl	_	_
5	the	the	DT	DT	_	8	det	_	_
6	well-defined	well-defined	JJ	JJ	_	8	amod	_	_
7	phenotypic	phenotypic	JJ	JJ	_	6	dep	_	_
8	changes	change	NNS	NNS	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	differentiating	differentiate	VBG	VBG	_	12	amod	_	_
12	thymocyte	thymocyte	NN	NN	_	8	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	poorly	poorly	RB	RB	_	15	advmod	_	_
15	understood	understand	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	candidate	candidate	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	16	nsubj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	control	control	VB	VB	_	3	acl	_	_
6	thymocyte	thymocyte	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	3	punct	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	factor-1	factor-1	NN	NN	_	3	appos	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TCF-1	tcf-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	*	*	SYM	SYM	_	13	dep	_	_
16	encodes	encode	VBZ	VBZ	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	DNA-binding	dna-binding	JJ	JJ	_	19	amod	_	_
19	protein	protein	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	Its	its	PRP$	PRP$	_	4	nmod:poss	_	_
2	mRNA	mrna	NN	NN	_	4	compound	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	pattern	pattern	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	complex	complex	JJ	JJ	_	0	root	_	_
7	during	during	IN	IN	_	8	case	_	_
8	embryogenesis	embryogenesis	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	yet	yet	RB	RB	_	6	advmod	_	_
11	restricted	restricted	JJ	JJ	_	6	dep	_	_
12	to	to	TO	TO	_	13	case	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
14	postnatally	postnatally	RB	RB	_	11	advmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	8	nsubjpass	_	_
3	on	on	IN	IN	_	5	case	_	_
4	TCF-1	tcf-1	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	have	have	VBP	VBP	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	hampered	hamper	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	difficulty	difficulty	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	raise	raise	VB	VB	_	11	acl	_	_
14	antibodies	antibody	NNS	NNS	_	13	dobj	_	_
15	due	due	JJ	JJ	_	11	amod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	extreme	extreme	JJ	JJ	_	18	amod	_	_
18	evolutionary	evolutionary	JJ	JJ	_	19	amod	_	_
19	conservation	conservation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	TCF-1	tcf-1	NN	NN	_	3	compound	_	_
2	knock-out	knock-out	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	generated	generate	VBN	VBN	_	3	acl	_	_
6	recently	recently	RB	RB	_	5	advmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	our	we	PRP$	PRP$	_	9	nmod:poss	_	_
9	laboratory	laboratory	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	strongly	strongly	RB	RB	_	13	advmod	_	_
13	decreased	decrease	VBN	VBN	_	0	root	_	_
14	numbers	number	NNS	NNS	_	13	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	thymocytes	thymocyte	NNS	NNS	_	14	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	are	be	VBP	VBP	_	21	cop	_	_
20	otherwise	otherwise	RB	RB	_	21	advmod	_	_
21	normal	normal	JJ	JJ	_	13	conj	_	_
22	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	these	these	DT	DT	_	5	det	_	_
5	mice	mouse	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	generate	generate	VB	VB	_	3	xcomp	_	_
8	anti-TCF-1	anti-tcf-1	NN	NN	_	9	compound	_	_
9	antibodies	antibody	NNS	NNS	_	7	dobj	_	_
10	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	immunization	immunization	NN	NN	_	10	nmod	_	_
3	with	with	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
6	fusion	fusion	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	TCF-1	tcf-1	NN	NN	_	14	compound	_	_
13	knock-out	knock-out	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	16	nsubj	_	_
15	readily	readily	RB	RB	_	16	advmod	_	_
16	yield	yield	VBP	VBP	_	10	ccomp	_	_
17	antiserum	antiserum	NN	NN	_	18	compound	_	_
18	titers	titer	NNS	NNS	_	16	dobj	_	_
19	against	against	IN	IN	_	20	case	_	_
20	human	human	JJ	JJ	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	mouse	mouse	NN	NN	_	20	conj	_	_
23	TCF-1	tcf-1	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	20	dep	_	_
25	.	.	.	.	_	10	punct	_	_

1	Wild-type	wild-type	JJ	JJ	_	2	amod	_	_
2	littermates	littermate	NNS	NNS	_	3	nsubj	_	_
3	remain	remain	VBP	VBP	_	0	root	_	_
4	unresponsive	unresponsive	JJ	JJ	_	3	xcomp	_	_
5	to	to	TO	TO	_	6	case	_	_
6	TCF-1	tcf-1	NN	NN	_	4	nmod	_	_
7	while	while	IN	IN	_	9	mark	_	_
8	they	they	PRP	PRP	_	9	nsubj	_	_
9	mount	mount	VBP	VBP	_	3	advcl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	high-titer	high-titer	JJ	JJ	_	13	amod	_	_
12	antibody	antibody	NN	NN	_	13	compound	_	_
13	response	response	NN	NN	_	9	dobj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	fusion	fusion	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	Maltose	maltose	NN	NN	_	21	compound	_	_
20	Binding	binding	NN	NN	_	21	compound	_	_
21	Protein	protein	NN	NN	_	17	appos	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	MBP	mbp	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	Subsequently	subsequently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	TCF-1-specific	tcf-1-specific	JJ	JJ	_	4	amod	_	_
4	hybridomas	hybridoma	NNS	NNS	_	7	nsubjpass	_	_
5	could	could	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	prepared	prepare	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	spleens	spleen	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	immunized	immunize	VBN	VBN	_	14	amod	_	_
13	knock-out	knock-out	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	illustrates	illustrate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	almost	almost	RB	RB	_	6	advmod	_	_
6	complete	complete	JJ	JJ	_	7	amod	_	_
7	tolerance	tolerance	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	mice	mouse	NNS	NNS	_	7	nmod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	TCF-1	tcf-1	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	demonstrates	demonstrate	VBZ	VBZ	_	3	conj	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	tolerance	tolerance	NN	NN	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	readily	readily	RB	RB	_	20	advmod	_	_
20	broken	break	VBN	VBN	_	14	ccomp	_	_
21	by	by	IN	IN	_	23	case	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	knock-out	knock-out	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	usefulness	usefulness	NN	NN	_	21	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	knock-out	knock-out	JJ	JJ	_	7	amod	_	_
7	mice	mouse	NNS	NNS	_	4	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	generation	generation	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	monoclonal	monoclonal	JJ	JJ	_	13	amod	_	_
13	antibodies	antibody	NNS	NNS	_	10	nmod	_	_
14	against	against	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	product	product	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	interest	interest	NN	NN	_	17	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	underscored	underscore	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	interferon-gamma	interferon-gamma	NN	NN	_	4	compound	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	5	nsubj	_	_
5	mediates	mediate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	IgG	igg	NN	NN	_	16	compound	_	_
12	Fc	fc	NN	NN	_	16	compound	_	_
13	receptor	receptor	NN	NN	_	16	compound	_	_
14	type	type	NN	NN	_	16	compound	_	_
15	IC	ic	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	8	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	interferon-gamma	interferon-gamma	NN	NN	_	8	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	19	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	IgG	igg	NN	NN	_	7	compound	_	_
5	Fc	fc	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	1	nmod	_	_
8	I	i	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	Fc	fc	NN	NN	_	12	compound	_	_
11	gamma	gamma	NN	NN	_	12	compound	_	_
12	RI	ri	NN	NN	_	7	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	on	on	IN	IN	_	16	case	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	1	nmod	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	dramatically	dramatically	RB	RB	_	19	advmod	_	_
19	increased	increase	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	21	case	_	_
21	treatment	treatment	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	interferon-gamma	interferon-gamma	NN	NN	_	21	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	IFN-gamma	ifn-gamma	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	Fc	fc	NN	NN	_	6	compound	_	_
5	gamma	gamma	NN	NN	_	6	compound	_	_
6	RI	ri	NN	NN	_	8	compound	_	_
7	transcript	transcript	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	14	nsubjpass	_	_
9	in	in	IN	IN	_	12	case	_	_
10	monoblast-like	monoblast-like	JJ	JJ	_	12	amod	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	elevated	elevate	VBN	VBN	_	2	ccomp	_	_
15	within	within	IN	IN	_	17	case	_	_
16	3	3	CD	CD	_	17	nummod	_	_
17	hr	hr	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	peaked	peak	VBD	VBD	_	14	conj	_	_
20	12	12	CD	CD	_	21	nummod	_	_
21	hr	hr	NN	NN	_	19	nmod	_	_
22	after	after	IN	IN	_	21	case	_	_
23	exposure	exposure	NN	NN	_	21	dep	_	_
24	to	to	TO	TO	_	25	case	_	_
25	IFN-gamma	ifn-gamma	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	U937	u937	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	9	9	CD	CD	_	8	nummod	_	_
8	hr	hr	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cycloheximide	cycloheximide	NN	NN	_	11	nmod	_	_
14	led	lead	VBD	VBD	_	0	root	_	_
15	to	to	TO	TO	_	16	case	_	_
16	super-induction	super-induction	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	Fc	fc	NN	NN	_	20	compound	_	_
19	gamma	gamma	NN	NN	_	20	compound	_	_
20	RI	ri	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	rate	rate	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	12	case	_	_
9	Fc	fc	NN	NN	_	11	compound	_	_
10	gamma	gamma	NN	NN	_	11	compound	_	_
11	RI	ri	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	increased	increase	VBN	VBN	_	4	ccomp	_	_
15	by	by	IN	IN	_	16	case	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Genomic	genomic	JJ	JJ	_	2	amod	_	_
2	sequence	sequence	NN	NN	_	11	nsubjpass	_	_
3	upstream	upstream	JJ	JJ	_	2	advmod	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Fc	fc	NN	NN	_	9	compound	_	_
7	gamma	gamma	NN	NN	_	9	compound	_	_
8	RIC	ric	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	3	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	cloned	clone	VBN	VBN	_	0	root	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	subjected	subject	VBN	VBN	_	11	conj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	primer	primer	NN	NN	_	17	compound	_	_
16	extension	extension	NN	NN	_	17	compound	_	_
17	analysis	analysis	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	demonstrated	demonstrate	VBD	VBD	_	17	acl:relcl	_	_
21	a	a	DT	DT	_	25	det	_	_
22	single	single	JJ	JJ	_	25	amod	_	_
23	transcription	transcription	NN	NN	_	25	compound	_	_
24	initiation	initiation	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	20	dobj	_	_
26	without	without	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	TATA	tata	NN	NN	_	29	compound	_	_
29	box	box	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfections	transfection	NNS	NNS	_	18	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	CAT	cat	NN	NN	_	7	compound	_	_
5	reporter	reporter	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	2	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	various	various	JJ	JJ	_	14	amod	_	_
10	Fc	fc	NN	NN	_	14	compound	_	_
11	gamma	gamma	NN	NN	_	14	compound	_	_
12	RIC	ric	NN	NN	_	14	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	sequences	sequence	NNS	NNS	_	8	dobj	_	_
15	into	into	IN	IN	_	17	case	_	_
16	U937	u937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	2	nmod	_	_
18	revealed	reveal	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	34	mark	_	_
20	a	a	DT	DT	_	22	det	_	_
21	20-bp	20-bp	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	34	nsubj	_	_
23	surrounding	surround	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	27	det	_	_
25	transcription	transcription	NN	NN	_	27	compound	_	_
26	start	start	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	23	dobj	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	-7	-7	CD	CD	_	31	compound	_	_
30	to	to	TO	TO	_	31	dep	_	_
31	+13	+13	CD	CD	_	27	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	was	be	VBD	VBD	_	34	cop	_	_
34	capable	capable	JJ	JJ	_	18	ccomp	_	_
35	of	of	IN	IN	_	36	mark	_	_
36	mediating	mediate	VBG	VBG	_	34	advcl	_	_
37	transcription	transcription	NN	NN	_	38	compound	_	_
38	initiation	initiation	NN	NN	_	36	dobj	_	_
39	and	and	CC	CC	_	34	cc	_	_
40	that	that	IN	IN	_	49	mark	_	_
41	an	a	DT	DT	_	44	det	_	_
42	IFN-gamma	ifn-gamma	NN	NN	_	44	compound	_	_
43	responsive	responsive	JJ	JJ	_	44	amod	_	_
44	element	element	NN	NN	_	49	nsubj	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	GIRE	gire	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	was	be	VBD	VBD	_	49	cop	_	_
49	present	present	JJ	JJ	_	34	conj	_	_
50	within	within	IN	IN	_	52	case	_	_
51	74	74	CD	CD	_	52	nummod	_	_
52	bp	bp	NN	NN	_	49	nmod	_	_
53	upstream	upstream	JJ	JJ	_	52	amod	_	_
54	of	of	IN	IN	_	58	case	_	_
55	the	the	DT	DT	_	58	det	_	_
56	transcription	transcription	NN	NN	_	58	compound	_	_
57	initiation	initiation	NN	NN	_	58	compound	_	_
58	site	site	NN	NN	_	52	nmod	_	_
59	.	.	.	.	_	18	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	17-bp	17-bp	JJ	JJ	_	3	amod	_	_
3	sequence	sequence	NN	NN	_	9	nsubj	_	_
4	between	between	IN	IN	_	5	case	_	_
5	positions	position	NNS	NNS	_	3	nmod	_	_
6	-51	-51	CD	CD	_	5	nummod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	-35	-35	CD	CD	_	6	conj	_	_
9	conferred	confer	VBD	VBD	_	0	root	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	11	compound	_	_
11	responsiveness	responsiveness	NN	NN	_	9	dobj	_	_
12	on	on	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	heterologous	heterologous	JJ	JJ	_	15	amod	_	_
15	promoter	promoter	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Double-stranded	double-stranded	JJ	JJ	_	3	amod	_	_
2	GIRE	gire	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	13	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	3	cc	_	_
7	a	a	DT	DT	_	9	det	_	_
8	scrambled	scramble	VBN	VBN	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	specifically	specifically	RB	RB	_	13	advmod	_	_
13	bound	bind	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	from	from	IN	IN	_	21	case	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
19	treated	treated	JJ	JJ	_	21	amod	_	_
20	U937	u937	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	STAT1	stat1	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	11	nsubj	_	_
11	bound	bind	VBD	VBD	_	5	ccomp	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	Fc	fc	NN	NN	_	17	compound	_	_
15	gamma	gamma	NN	NN	_	17	compound	_	_
16	RIC	ric	NN	NN	_	17	compound	_	_
17	GIRE	gire	NN	NN	_	11	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	response	response	NN	NN	_	11	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	U937	u937	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Fc	fc	NN	NN	_	5	compound	_	_
3	gamma	gamma	NN	NN	_	5	compound	_	_
4	RIC	ric	NN	NN	_	5	compound	_	_
5	GIRE	gire	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	homologous	homologous	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	12	compound	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	GAS	gas	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	guanylate	guanylate	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	12	nmod	_	_
21	and	and	CC	CC	_	12	cc	_	_
22	to	to	TO	TO	_	25	case	_	_
23	X	x	NN	NN	_	25	compound	_	_
24	box	box	NN	NN	_	25	compound	_	_
25	elements	element	NNS	NNS	_	12	conj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	class	class	NN	NN	_	30	compound	_	_
28	II	ii	CD	CD	_	30	nummod	_	_
29	MHC	mhc	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	regulation	regulation	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	Fc	fc	NN	NN	_	12	compound	_	_
10	gamma	gamma	NN	NN	_	12	compound	_	_
11	RIC	ric	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	6	nmod	_	_
15	involves	involve	VBZ	VBZ	_	3	ccomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	binding	binding	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	STAT1	stat1	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	17-bp	17-bp	JJ	JJ	_	25	amod	_	_
24	GAS	gas	NN	NN	_	25	compound	_	_
25	homology	homology	NN	NN	_	17	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	proximal	proximal	JJ	JJ	_	29	amod	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Cloning	clone	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	3	det	_	_
3	cDNA	cdna	NN	NN	_	1	dobj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	NK/T	nk/t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	codes	code	VBZ	VBZ	_	7	acl:relcl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	9	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	high	high	JJ	JJ	_	16	amod	_	_
15	proline	proline	NN	NN	_	16	compound	_	_
16	content	content	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	8	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	B4-2	b4-2	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	isolated	isolate	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	natural	natural	JJ	JJ	_	14	amod	_	_
12	killer	killer	NN	NN	_	14	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NK	nk	NN	NN	_	8	nmod	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	minus	minus	CC	CC	_	14	cc	_	_
17	T	t	NN	NN	_	20	compound	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	subtractive	subtractive	JJ	JJ	_	20	amod	_	_
20	library	library	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	B4-2	b4-2	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	4	nsubj	_	_
4	coded	code	VBD	VBD	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	an	a	DT	DT	_	7	det	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	2061	2061	CD	CD	_	10	nummod	_	_
10	bp	bp	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	length	length	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	deduced	deduce	VBN	VBN	_	7	amod	_	_
5	327	327	CD	CD	_	7	nummod	_	_
6	aa	aa	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	dobj	_	_
8	with	with	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	calculated	calculate	VBN	VBN	_	12	amod	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	mass	mass	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	35.2	35.2	CD	CD	_	15	nummod	_	_
15	kDa	kda	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Searching	searching	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	B4-2	b4-2	NN	NN	_	4	compound	_	_
4	DNA	dna	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	sequences	sequence	NNS	NNS	_	4	conj	_	_
8	against	against	IN	IN	_	10	case	_	_
9	various	various	JJ	JJ	_	10	amod	_	_
10	databases	database	NNS	NNS	_	1	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	no	no	DT	DT	_	14	neg	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	homology	homology	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	sequences	sequence	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	B4-2	b4-2	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	9	det	_	_
6	unusually	unusually	RB	RB	_	7	advmod	_	_
7	high	high	JJ	JJ	_	9	amod	_	_
8	proline	proline	NN	NN	_	9	compound	_	_
9	content	content	NN	NN	_	4	dobj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	13	13	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	4	punct	_	_
15	contains	contain	VBZ	VBZ	_	4	conj	_	_
16	a	a	DT	DT	_	20	det	_	_
17	putative	putative	JJ	JJ	_	20	amod	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	targeting	targeting	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	15	dobj	_	_
21	,	,	,	,	_	4	punct	_	_
22	and	and	CC	CC	_	4	cc	_	_
23	has	have	VBZ	VBZ	_	4	conj	_	_
24	several	several	JJ	JJ	_	26	amod	_	_
25	SPXX	spxx	NN	NN	_	26	compound	_	_
26	motifs	motif	NNS	NNS	_	23	dobj	_	_
27	which	which	WDT	WDT	_	30	nsubjpass	_	_
28	are	be	VBP	VBP	_	30	auxpass	_	_
29	frequently	frequently	RB	RB	_	30	advmod	_	_
30	found	find	VBN	VBN	_	26	acl:relcl	_	_
31	in	in	IN	IN	_	34	case	_	_
32	gene	gene	NN	NN	_	34	compound	_	_
33	regulatory	regulatory	JJ	JJ	_	34	amod	_	_
34	proteins	protein	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	stretches	stretch	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	prolines	proline	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	B4-2	b4-2	NN	NN	_	6	nmod	_	_
9	closely	closely	RB	RB	_	10	advmod	_	_
10	resembles	resemble	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ligand	ligand	NN	NN	_	10	xcomp	_	_
13	for	for	IN	IN	_	14	case	_	_
14	proteins	protein	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	SH3	sh3	NN	NN	_	17	compound	_	_
17	domains	domain	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	hybridization	hybridization	NN	NN	_	3	compound	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	B4-2	b4-2	NN	NN	_	12	nsubj	_	_
7	is	be	VBZ	VBZ	_	12	cop	_	_
8	not	not	RB	RB	_	12	neg	_	_
9	a	a	DT	DT	_	12	det	_	_
10	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	4	ccomp	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	expressed	express	VBN	VBN	_	12	conj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	hepatoma	hepatoma	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	also	also	RB	RB	_	15	conj	_	_
23	weakly	weakly	RB	RB	_	24	advmod	_	_
24	transcribed	transcribe	VBN	VBN	_	15	conj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	absent	absent	JJ	JJ	_	24	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	variety	variety	NN	NN	_	24	dep	_	_
30	of	of	IN	IN	_	32	case	_	_
31	other	other	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	polyclonal	polyclonal	JJ	JJ	_	3	amod	_	_
3	antiserum	antiserum	NN	NN	_	8	nsubj	_	_
4	raised	raise	VBN	VBN	_	3	acl	_	_
5	against	against	IN	IN	_	7	case	_	_
6	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
7	B4-2	b4-2	NN	NN	_	4	nmod	_	_
8	recognizes	recognize	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	32-34	32-34	CD	CD	_	12	nummod	_	_
11	kDa	kda	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	murine	murine	JJ	JJ	_	4	amod	_	_
3	BCL6	bcl6	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	activated	activate	VBN	VBN	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	as	as	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	immediate	immediate	JJ	JJ	_	14	amod	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	gene	gene	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chromosomal	chromosomal	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	8	nsubjpass	_	_
4	involving	involve	VBG	VBG	_	3	acl	_	_
5	3q27	3q27	NN	NN	_	4	dobj	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	often	often	RB	RB	_	8	advmod	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	lymphomas	lymphoma	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	especially	especially	RB	RB	_	16	advmod	_	_
15	diffuse	diffuse	JJ	JJ	_	16	amod	_	_
16	lymphomas	lymphoma	NNS	NNS	_	12	appos	_	_
17	with	with	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	large-cell	large-cell	JJ	JJ	_	20	amod	_	_
20	component	component	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	BCL6	bcl6	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	isolated	isolate	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	chromosomal	chromosomal	JJ	JJ	_	10	amod	_	_
10	breakpoint	breakpoint	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	lymphomas	lymphoma	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	cloned	clone	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	10	det	_	_
5	murine	murine	JJ	JJ	_	10	amod	_	_
6	BCL6	bcl6	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	mBCL6	mbcl6	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	cDNA	cdna	NN	NN	_	3	dobj	_	_
11	from	from	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	muscle	muscle	NN	NN	_	15	compound	_	_
14	cDNA	cdna	NN	NN	_	15	compound	_	_
15	library	library	NN	NN	_	3	nmod	_	_
16	using	use	VBG	VBG	_	3	xcomp	_	_
17	the	the	DT	DT	_	23	det	_	_
18	human	human	JJ	JJ	_	23	amod	_	_
19	BCL6	bcl6	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	hBCL6	hbcl6	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	cDNA	cdna	NN	NN	_	16	dobj	_	_
24	as	as	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	probe	probe	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	predicted	predict	VBN	VBN	_	5	amod	_	_
3	amino	amino	NN	NN	_	5	compound	_	_
4	acid	acid	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	9	nsubj	_	_
6	was	be	VBD	VBD	_	9	cop	_	_
7	95	95	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	9	nmod:npmod	_	_
9	identical	identical	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	that	that	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	hBCL6	hbcl6	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	six	six	CD	CD	_	4	nummod	_	_
4	repeats	repeat	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	Kruppel-like	kruppel-like	JJ	JJ	_	9	amod	_	_
8	zinc-finger	zinc-finger	JJ	JJ	_	9	amod	_	_
9	motif	motif	NN	NN	_	4	nmod	_	_
10	that	that	WDT	WDT	_	13	nsubj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	completely	completely	RB	RB	_	13	advmod	_	_
13	identical	identical	JJ	JJ	_	4	acl:relcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	those	those	DT	DT	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	hBCL6	hbcl6	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	indicating	indicate	VBG	VBG	_	2	advcl	_	_
20	that	that	IN	IN	_	26	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	BCL6	bcl6	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	26	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	well	well	RB	RB	_	26	advmod	_	_
26	conserved	conserve	VBN	VBN	_	19	ccomp	_	_
27	between	between	IN	IN	_	28	case	_	_
28	humans	human	NNS	NNS	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	mice	mouse	NNS	NNS	_	28	conj	_	_
31	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	mBCL6	mbcl6	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	ubiquitously	ubiquitously	RB	RB	_	8	advmod	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	adult	adult	JJ	JJ	_	12	amod	_	_
11	mouse	mouse	NN	NN	_	12	compound	_	_
12	tissues	tissue	NNS	NNS	_	8	nmod	_	_
13	including	include	VBG	VBG	_	15	case	_	_
14	lymphatic	lymphatic	JJ	JJ	_	15	amod	_	_
15	organs	organ	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
8	activated	activate	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	phorbol	phorbol	NN	NN	_	11	compound	_	_
11	ester	ester	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Ca2+	ca2+	NN	NN	_	14	compound	_	_
14	ionophore	ionophore	NN	NN	_	11	conj	_	_
15	within	within	IN	IN	_	17	case	_	_
16	30	30	CD	CD	_	17	nummod	_	_
17	min	min	NN	NN	_	8	nmod	_	_
18	after	after	IN	IN	_	19	case	_	_
19	stimulation	stimulation	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	treatment	treatment	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	with	with	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	synthesis	synthesis	NN	NN	_	15	compound	_	_
15	inhibitor	inhibitor	NN	NN	_	7	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	cycloheximide	cycloheximide	NN	NN	_	15	appos	_	_
18	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	BCL6	bcl6	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	activated	activate	VBN	VBN	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
12	as	as	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	immediate	immediate	JJ	JJ	_	16	amod	_	_
15	early	early	JJ	JJ	_	16	amod	_	_
16	gene	gene	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	normal	normal	JJ	JJ	_	6	amod	_	_
3	cell	cell	NN	NN	_	6	compound	_	_
4	cycle	cycle	NN	NN	_	6	compound	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	program	program	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	exploited	exploit	VBN	VBN	_	0	root	_	_
9	during	during	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	infection	infection	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	quiescent	quiescent	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	Epstein-Barr	epstein-barr	JJ	JJ	_	18	amod	_	_
18	virus	virus	NN	NN	_	8	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
6	circulation	circulation	NN	NN	_	2	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	maintained	maintained	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	non-proliferative	non-proliferative	JJ	JJ	_	12	amod	_	_
12	state	state	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Antigen	antigen	NN	NN	_	2	compound	_	_
2	recognition	recognition	NN	NN	_	3	nsubj	_	_
3	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
4	limited	limited	JJ	JJ	_	5	amod	_	_
5	proliferation	proliferation	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	3	punct	_	_
7	whereas	whereas	IN	IN	_	15	mark	_	_
8	infection	infection	NN	NN	_	15	nsubj	_	_
9	with	with	IN	IN	_	11	case	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
11	virus	virus	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	EBV	ebv	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	results	result	VBZ	VBZ	_	3	advcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	continual	continual	JJ	JJ	_	18	amod	_	_
18	proliferation	proliferation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	outgrowth	outgrowth	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	immortal	immortal	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	18	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	it	it	PRP	PRP	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	clear	clear	JJ	JJ	_	20	advcl	_	_
6	at	at	IN	IN	_	8	case	_	_
7	which	which	WDT	WDT	_	8	det	_	_
8	point	point	NN	NN	_	17	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	cycle	cycle	NN	NN	_	8	nmod	_	_
12	the	the	DT	DT	_	15	det	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	arrested	arrest	VBN	VBN	_	5	ccomp	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	characterized	characterize	VBD	VBD	_	0	root	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	several	several	JJ	JJ	_	27	amod	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	cycle-associated	cycle-associated	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	22	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	quiescent	quiescent	JJ	JJ	_	22	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	stimulated	stimulate	VBN	VBN	_	29	conj	_	_
32	cells	cell	NNS	NNS	_	29	dep	_	_
33	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	23	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	23	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	four	four	CD	CD	_	9	nummod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	cdc-2	cdc-2	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	11	punct	_	_
13	cyclin	cyclin	NN	NN	_	14	compound	_	_
14	E	e	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	CD23	cd23	NN	NN	_	11	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	cyclin	cyclin	NN	NN	_	20	compound	_	_
20	D2	d2	NN	NN	_	11	conj	_	_
21	,	,	,	,	_	5	punct	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	up-regulated	up-regulate	VBN	VBN	_	2	ccomp	_	_
24	approximately	approximately	RB	RB	_	25	advmod	_	_
25	100-fold	100-fold	RB	RB	_	23	dobj	_	_
26	as	as	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	result	result	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	EBV-mediated	ebv-mediated	JJ	JJ	_	31	amod	_	_
31	immortalization	immortalization	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	4	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	genes	gene	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	13	advcl	_	_
5	a	a	DT	DT	_	7	det	_	_
6	positive	positive	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	proliferation	proliferation	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	suggest	suggest	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	this	this	DT	DT	_	17	det	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	switch	switch	NN	NN	_	18	nsubj	_	_
18	contributes	contribute	VBZ	VBZ	_	13	ccomp	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	controlling	control	VBG	VBG	_	18	advcl	_	_
21	entry	entry	NN	NN	_	20	dobj	_	_
22	into	into	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	cycle	cycle	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	stimulation	stimulation	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	quiescent	quiescent	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	either	either	CC	CC	_	10	cc:preconj	_	_
9	a	a	DT	DT	_	10	det	_	_
10	cocktail	cocktail	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	anti-CD40	anti-cd40	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	anti-IgM	anti-igm	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	IL4	il4	NN	NN	_	12	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	or	or	CC	CC	_	10	cc	_	_
20	EBV	ebv	NN	NN	_	10	conj	_	_
21	results	result	VBZ	VBZ	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	rapid	rapid	JJ	JJ	_	25	amod	_	_
25	expression	expression	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	same	same	JJ	JJ	_	30	amod	_	_
29	four	four	CD	CD	_	30	nummod	_	_
30	genes	gene	NNS	NNS	_	25	nmod	_	_
31	,	,	,	,	_	21	punct	_	_
32	suggesting	suggest	VBG	VBG	_	21	xcomp	_	_
33	that	that	IN	IN	_	39	mark	_	_
34	,	,	,	,	_	39	punct	_	_
35	after	after	IN	IN	_	36	case	_	_
36	infection	infection	NN	NN	_	39	nmod	_	_
37	,	,	,	,	_	39	punct	_	_
38	EBV	ebv	NN	NN	_	39	nsubj	_	_
39	exploits	exploit	VBZ	VBZ	_	32	ccomp	_	_
40	the	the	DT	DT	_	42	det	_	_
41	normal	normal	JJ	JJ	_	42	amod	_	_
42	program	program	NN	NN	_	39	dobj	_	_
43	of	of	IN	IN	_	47	case	_	_
44	B-lymphocyte	b-lymphocyte	NN	NN	_	47	compound	_	_
45	cell	cell	NN	NN	_	47	compound	_	_
46	cycle	cycle	NN	NN	_	47	compound	_	_
47	activation	activation	NN	NN	_	42	nmod	_	_
48	.	.	.	.	_	21	punct	_	_

1	Vitamin	vitamin	NN	NN	_	3	compound	_	_
2	E	e	NN	NN	_	3	compound	_	_
3	therapy	therapy	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	acute	acute	JJ	JJ	_	8	amod	_	_
6	CCl4-induced	ccl4-induced	JJ	JJ	_	8	amod	_	_
7	hepatic	hepatic	JJ	JJ	_	8	amod	_	_
8	injury	injury	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	mice	mouse	NNS	NNS	_	3	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	inhibition	inhibition	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	kappa	kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Oxidative	oxidative	JJ	JJ	_	2	amod	_	_
2	stress	stress	NN	NN	_	11	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	with	with	IN	IN	_	8	case	_	_
5	reactive	reactive	JJ	JJ	_	8	amod	_	_
6	oxygen	oxygen	NN	NN	_	8	compound	_	_
7	intermediate	intermediate	NN	NN	_	8	compound	_	_
8	formation	formation	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	represent	represent	VB	VB	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	common	common	JJ	JJ	_	14	amod	_	_
14	mechanism	mechanism	NN	NN	_	11	dobj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	20	nmod	_	_
17	liver	liver	NN	NN	_	18	compound	_	_
18	injury	injury	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	induced	induce	VBN	VBN	_	14	acl:relcl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	diverse	diverse	JJ	JJ	_	23	amod	_	_
23	etiologies	etiology	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	Oxidative	oxidative	JJ	JJ	_	2	amod	_	_
2	stress	stress	NN	NN	_	3	nsubj	_	_
3	enhances	enhance	VBZ	VBZ	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	activity	activity	NN	NN	_	3	dobj	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	20	nsubjpass	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	3	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	enhance	enhance	VB	VB	_	20	xcomp	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	cytotoxic	cytotoxic	JJ	JJ	_	27	amod	_	_
27	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	hepatic	hepatic	JJ	JJ	_	3	amod	_	_
3	injury	injury	NN	NN	_	11	nsubjpass	_	_
4	caused	cause	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	9	case	_	_
6	reactive	reactive	JJ	JJ	_	9	amod	_	_
7	oxygen	oxygen	NN	NN	_	9	compound	_	_
8	intermediate	intermediate	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	4	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	intraperitoneal	intraperitoneal	JJ	JJ	_	15	amod	_	_
15	injection	injection	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CCl4	ccl4	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	mice	mouse	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	injury	injury	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	significantly	significantly	RB	RB	_	5	advmod	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	intravenous	intravenous	JJ	JJ	_	8	amod	_	_
8	pretreatment	pretreatment	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mice	mouse	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	water-soluble	water-soluble	JJ	JJ	_	15	amod	_	_
15	emulsion	emulsion	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	alpha-tocopherol	alpha-tocopherol	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Alpha-tocopherol	alpha-tocopherol	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mice	mouse	NNS	NNS	_	2	nmod	_	_
6	given	give	VBN	VBN	_	5	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	CCl4	ccl4	NN	NN	_	6	dobj	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	reduced	reduce	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	10	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	levels	level	NNS	NNS	_	10	nmod	_	_
17	approaching	approach	VBG	VBG	_	16	acl	_	_
18	those	those	DT	DT	_	17	dobj	_	_
19	found	find	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	normal	normal	JJ	JJ	_	22	amod	_	_
22	mice	mouse	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	treatment	treatment	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	monocyte/macrophage	monocyte/macrophage	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	3	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	CCl4	ccl4	NN	NN	_	3	nmod	_	_
11	led	lead	VBD	VBD	_	0	root	_	_
12	to	to	TO	TO	_	16	case	_	_
13	enhanced	enhance	VBN	VBN	_	16	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	an	a	DT	DT	_	19	det	_	_
19	increase	increase	NN	NN	_	16	conj	_	_
20	in	in	IN	IN	_	29	case	_	_
21	tumor	tumor	NN	NN	_	28	compound	_	_
22	necrosis	necrosis	NN	NN	_	28	compound	_	_
23	factor-alpha	factor-alpha	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	28	compound	_	_
26	)	)	-RRB-	-RRB-	_	28	punct	_	_
27	messenger	messenger	NN	NN	_	28	compound	_	_
28	RNA	rna	NN	NN	_	29	compound	_	_
29	levels	level	NNS	NNS	_	19	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	Liver	liver	NN	NN	_	2	compound	_	_
2	specimens	specimen	NNS	NNS	_	12	nsubj	_	_
3	taken	take	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	acute	acute	JJ	JJ	_	8	amod	_	_
8	fulminant	fulminant	JJ	JJ	_	9	amod	_	_
9	hepatitis	hepatitis	NN	NN	_	5	nmod	_	_
10	had	have	VBD	VBD	_	12	aux	_	_
11	markedly	markedly	RB	RB	_	12	advmod	_	_
12	increased	increase	VBN	VBN	_	0	root	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	comparison	comparison	NN	NN	_	12	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	binding	binding	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	livers	liver	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	abolishing	abolish	VBG	VBG	_	18	csubj	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	hepatic	hepatic	JJ	JJ	_	8	amod	_	_
8	injury	injury	NN	NN	_	5	dobj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	alpha-tocopherol	alpha-tocopherol	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	15	det	_	_
13	free	free	JJ	JJ	_	15	amod	_	_
14	radical	radical	NN	NN	_	15	compound	_	_
15	scavenger	scavenger	NN	NN	_	10	appos	_	_
16	,	,	,	,	_	5	punct	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	eliminated	eliminate	VBD	VBD	_	3	ccomp	_	_
19	increased	increase	VBN	VBN	_	22	amod	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	18	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	tempting	tempting	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	speculate	speculate	VB	VB	_	3	xcomp	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	enhanced	enhance	VBN	VBN	_	10	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	18	nsubj	_	_
11	caused	cause	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	16	case	_	_
13	free	free	JJ	JJ	_	16	amod	_	_
14	radical	radical	NN	NN	_	16	compound	_	_
15	production/oxidative	production/oxidative	JJ	JJ	_	16	amod	_	_
16	stress	stress	NN	NN	_	11	nmod	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	modulate	modulate	VB	VB	_	5	ccomp	_	_
19	liver	liver	NN	NN	_	20	compound	_	_
20	injury	injury	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	18	punct	_	_
22	perhaps	perhaps	RB	RB	_	25	advmod	_	_
23	through	through	IN	IN	_	25	case	_	_
24	an	a	DT	DT	_	25	det	_	_
25	effect	effect	NN	NN	_	18	nmod	_	_
26	on	on	IN	IN	_	29	case	_	_
27	cytotoxic	cytotoxic	JJ	JJ	_	28	amod	_	_
28	cytokine	cytokine	NN	NN	_	29	compound	_	_
29	synthesis	synthesis	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Toremifene	toremifene	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	some	some	DT	DT	_	10	det	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Toremifene	toremifene	NN	NN	_	2	nsubj	_	_
2	exerts	exert	VBZ	VBZ	_	0	root	_	_
3	multiple	multiple	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	varied	varied	JJ	JJ	_	3	conj	_	_
6	effects	effect	NNS	NNS	_	2	dobj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	6	case	_	_
2	short-term	short-term	JJ	JJ	_	6	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	in	in	FW	FW	_	2	dep	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	exposure	exposure	NN	NN	_	23	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	therapeutical	therapeutical	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	23	punct	_	_
11	distinct	distinct	JJ	JJ	_	12	amod	_	_
12	changes	change	NNS	NNS	_	23	nsubj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	P-glycoprotein	p-glycoprotein	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	steroid	steroid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	p53	p53	NN	NN	_	14	conj	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	Bcl-2	bcl-2	NN	NN	_	14	conj	_	_
22	expression	expression	NN	NN	_	14	dep	_	_
23	take	take	VBP	VBP	_	0	root	_	_
24	place	place	NN	NN	_	23	dobj	_	_
25	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	view	view	NN	NN	_	16	nmod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	increasing	increase	VBG	VBG	_	6	amod	_	_
6	use	use	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	antiestrogens	antiestrogen	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	cancer	cancer	NN	NN	_	6	nmod	_	_
11	therapy	therapy	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	prevention	prevention	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	16	punct	_	_
15	there	there	EX	EX	_	16	expl	_	_
16	is	be	VBZ	VBZ	_	0	root	_	_
17	obvious	obvious	JJ	JJ	_	18	amod	_	_
18	merit	merit	NN	NN	_	16	nsubj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	long-term	long-term	JJ	JJ	_	23	amod	_	_
21	in	in	FW	FW	_	20	dep	_	_
22	vivo	vivo	FW	FW	_	21	dep	_	_
23	studies	study	NNS	NNS	_	16	nmod	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	conducted	conduct	VBN	VBN	_	23	acl	_	_
27	.	.	.	.	_	16	punct	_	_

1	BCL-6	bcl-6	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	pathogenesis	pathogenesis	NN	NN	_	1	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	lymphoma	lymphoma	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	presented	present	VBN	VBN	_	2	acl	_	_
4	identify	identify	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	first	first	JJ	JJ	_	8	amod	_	_
7	genetic	genetic	JJ	JJ	_	8	amod	_	_
8	lesion	lesion	NN	NN	_	4	dobj	_	_
9	associated	associate	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	DLCL	dlcl	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	the	the	DT	DT	_	17	det	_	_
14	most	most	RBS	RBS	_	16	advmod	_	_
15	clinically	clinically	RB	RB	_	16	advmod	_	_
16	relevant	relevant	JJ	JJ	_	17	amod	_	_
17	form	form	NN	NN	_	11	appos	_	_
18	of	of	IN	IN	_	19	case	_	_
19	NHL	nhl	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	no	no	DT	DT	_	3	neg	_	_
3	proof	proof	NN	NN	_	5	nsubj	_	_
4	yet	yet	RB	RB	_	5	advmod	_	_
5	exists	exist	VBZ	VBZ	_	43	advcl	_	_
6	of	of	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	5	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	lesions	lesion	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	DLCL	dlcl	NN	NN	_	14	compound	_	_
14	pathogenesis	pathogenesis	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	43	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	feature	feature	NN	NN	_	43	nsubj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	BCL-6	bcl-6	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	product	product	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	17	punct	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	specific	specific	JJ	JJ	_	26	amod	_	_
26	pattern	pattern	NN	NN	_	17	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	expression	expression	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	26	nmod	_	_
32	,	,	,	,	_	17	punct	_	_
33	and	and	CC	CC	_	17	cc	_	_
34	the	the	DT	DT	_	35	det	_	_
35	clustering	clustering	NN	NN	_	17	conj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	lesions	lesion	NNS	NNS	_	35	nmod	_	_
38	disrupting	disrupt	VBG	VBG	_	35	acl	_	_
39	its	its	PRP$	PRP$	_	41	nmod:poss	_	_
40	regulatory	regulatory	JJ	JJ	_	41	amod	_	_
41	domain	domain	NN	NN	_	38	dobj	_	_
42	strongly	strongly	RB	RB	_	43	advmod	_	_
43	suggest	suggest	VBP	VBP	_	0	root	_	_
44	that	that	IN	IN	_	50	mark	_	_
45	deregulation	deregulation	NN	NN	_	50	nsubj	_	_
46	of	of	IN	IN	_	48	case	_	_
47	BCL-6	bcl-6	NN	NN	_	48	compound	_	_
48	expression	expression	NN	NN	_	45	nmod	_	_
49	may	may	MD	MD	_	50	aux	_	_
50	contribute	contribute	VB	VB	_	43	ccomp	_	_
51	to	to	TO	TO	_	53	case	_	_
52	DLCL	dlcl	NN	NN	_	53	compound	_	_
53	development	development	NN	NN	_	50	nmod	_	_
54	.	.	.	.	_	43	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	more	more	RBR	RBR	_	3	advmod	_	_
3	precise	precise	JJ	JJ	_	4	amod	_	_
4	definition	definition	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	BCL-6	bcl-6	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	normal	normal	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	neoplastic	neoplastic	JJ	JJ	_	11	conj	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	7	nmod	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	the	the	DT	DT	_	18	det	_	_
18	goal	goal	NN	NN	_	0	root	_	_
19	of	of	IN	IN	_	21	case	_	_
20	ongoing	ongoing	JJ	JJ	_	21	amod	_	_
21	study	study	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transgenic	transgenic	JJ	JJ	_	24	amod	_	_
24	mice	mouse	NNS	NNS	_	21	nmod	_	_
25	engineered	engineer	VBN	VBN	_	24	acl	_	_
26	either	either	CC	CC	_	28	cc:preconj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	express	express	VB	VB	_	25	ccomp	_	_
29	BCL-6	bcl-6	NN	NN	_	28	dobj	_	_
30	under	under	IN	IN	_	32	case	_	_
31	heterologous	heterologous	JJ	JJ	_	32	amod	_	_
32	promoters	promoter	NNS	NNS	_	28	nmod	_	_
33	or	or	CC	CC	_	28	cc	_	_
34	lacking	lack	VBG	VBG	_	28	conj	_	_
35	BCL-6	bcl-6	NN	NN	_	36	compound	_	_
36	function	function	NN	NN	_	34	dobj	_	_
37	due	due	JJ	JJ	_	40	case	_	_
38	to	to	TO	TO	_	37	mwe	_	_
39	targeted	target	VBN	VBN	_	40	amod	_	_
40	deletions	deletion	NNS	NNS	_	34	nmod	_	_
41	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	addition	addition	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	contributing	contribute	VBG	VBG	_	18	advcl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	understanding	understanding	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	DLCL	dlcl	NN	NN	_	10	compound	_	_
10	pathogenesis	pathogenesis	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	identification	identification	NN	NN	_	18	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	BCL-6	bcl-6	NN	NN	_	16	compound	_	_
16	lesions	lesion	NNS	NNS	_	13	nmod	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	have	have	VB	VB	_	0	root	_	_
19	relevant	relevant	JJ	JJ	_	21	amod	_	_
20	clinical	clinical	JJ	JJ	_	21	amod	_	_
21	implications	implication	NNS	NNS	_	18	dobj	_	_
22	.	.	.	.	_	18	punct	_	_

1	DLCL	dlcl	NN	NN	_	2	nsubj	_	_
2	represent	represent	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	heterogeneous	heterogeneous	JJ	JJ	_	5	amod	_	_
5	group	group	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	neoplasms	neoplasm	NNS	NNS	_	5	nmod	_	_
8	which	which	WDT	WDT	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	treated	treat	VBN	VBN	_	7	acl:relcl	_	_
11	homogeneously	homogeneously	RB	RB	_	10	advmod	_	_
12	despite	despite	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	fact	fact	NN	NN	_	10	nmod	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	only	only	RB	RB	_	17	advmod	_	_
17	50	50	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	21	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	18	nmod	_	_
21	experience	experience	VBP	VBP	_	14	ccomp	_	_
22	long-term	long-term	JJ	JJ	_	24	amod	_	_
23	disease-free	disease-free	JJ	JJ	_	24	amod	_	_
24	survival	survival	NN	NN	_	21	dobj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Schneider	Schneider	NNP	NNP	_	2	dep	_	_
27	et	et	FW	FW	_	28	compound	_	_
28	al.	al.	FW	FW	_	26	advmod	_	_
29	1990	1990	CD	CD	_	26	dep	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	fact	fact	NN	NN	_	14	nsubj	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	BCL-6	bcl-6	NN	NN	_	5	compound	_	_
5	rearrangements	rearrangement	NNS	NNS	_	6	nsubj	_	_
6	identify	identify	VBP	VBP	_	2	ccomp	_	_
7	biologically	biologically	RB	RB	_	8	advmod	_	_
8	and	and	CC	CC	_	10	advmod	_	_
9	clinically	clinically	RB	RB	_	8	advmod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	subsets	subset	NNS	NNS	_	6	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	DLCL	dlcl	NN	NN	_	11	nmod	_	_
14	suggests	suggest	VBZ	VBZ	_	0	root	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	these	these	DT	DT	_	17	det	_	_
17	lesions	lesion	NNS	NNS	_	20	nsubj	_	_
18	may	may	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	useful	useful	JJ	JJ	_	14	ccomp	_	_
21	as	as	IN	IN	_	22	case	_	_
22	markers	marker	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	selection	selection	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	differential	differential	JJ	JJ	_	28	amod	_	_
27	therapeutic	therapeutic	JJ	JJ	_	28	amod	_	_
28	strategies	strategy	NNS	NNS	_	24	nmod	_	_
29	based	base	VBN	VBN	_	33	case	_	_
30	on	on	IN	IN	_	33	case	_	_
31	different	different	JJ	JJ	_	33	amod	_	_
32	risk	risk	NN	NN	_	33	compound	_	_
33	groups	group	NNS	NNS	_	24	nmod	_	_
34	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	BCL-6	bcl-6	NN	NN	_	5	compound	_	_
5	rearrangements	rearrangement	NNS	NNS	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	identify	identify	VB	VB	_	8	xcomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	monitor	monitor	VB	VB	_	10	conj	_	_
13	the	the	DT	DT	_	15	det	_	_
14	malignant	malignant	JJ	JJ	_	15	amod	_	_
15	clone	clone	NN	NN	_	10	dobj	_	_
16	with	with	IN	IN	_	19	case	_	_
17	sensitive	sensitive	JJ	JJ	_	19	amod	_	_
18	PCR-based	pcr-based	JJ	JJ	_	19	amod	_	_
19	techniques	technique	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	remission	remission	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	18	advcl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	fraction	fraction	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	DLCL	dlcl	NN	NN	_	13	compound	_	_
13	cases	case	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	these	these	DT	DT	_	16	det	_	_
16	markers	marker	NNS	NNS	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	serve	serve	VB	VB	_	0	root	_	_
19	as	as	IN	IN	_	21	case	_	_
20	critical	critical	JJ	JJ	_	21	amod	_	_
21	tools	tool	NNS	NNS	_	18	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	sensitive	sensitive	JJ	JJ	_	24	amod	_	_
24	monitoring	monitoring	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	minimal	minimal	JJ	JJ	_	28	amod	_	_
27	residual	residual	JJ	JJ	_	28	amod	_	_
28	disease	disease	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	early	early	JJ	JJ	_	31	amod	_	_
31	diagnosis	diagnosis	NN	NN	_	24	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	relapse	relapse	NN	NN	_	31	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	Gribben	Gribben	NNP	NNP	_	18	dep	_	_
36	et	et	FW	FW	_	37	compound	_	_
37	al.	al.	FW	FW	_	35	advmod	_	_
38	1993	1993	CD	CD	_	35	dep	_	_
39	)	)	-RRB-	-RRB-	_	35	punct	_	_
40	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	DNA	dna	NN	NN	_	13	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	steroid	steroid	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	domains	domain	NNS	NNS	_	2	conj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	2	nmod	_	_
11	are	be	VBP	VBP	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	altered	alter	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	treated	treat	VBN	VBN	_	20	amod	_	_
19	CLL	cll	NN	NN	_	20	compound	_	_
20	patients	patient	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	investigate	investigate	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	16	mark	_	_
10	mutations	mutation	NNS	NNS	_	16	nsubj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	could	could	MD	MD	_	16	aux	_	_
16	account	account	VB	VB	_	8	ccomp	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	increasing	increase	VBG	VBG	_	20	amod	_	_
20	unresponsiveness	unresponsiveness	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	patients	patient	NNS	NNS	_	20	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	chronic	chronic	JJ	JJ	_	26	amod	_	_
25	lymphatic	lymphatic	JJ	JJ	_	26	amod	_	_
26	leukemia	leukemia	NN	NN	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CLL	cll	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	to	to	TO	TO	_	32	case	_	_
31	combination	combination	NN	NN	_	32	compound	_	_
32	chemotherapy	chemotherapy	NN	NN	_	20	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	receptor	receptor	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	tested	test	VBN	VBN	_	0	root	_	_
5	immunocytochemically	immunocytochemically	RB	RB	_	12	advmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	in	in	IN	IN	_	10	case	_	_
8	steroid	steroid	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	assays	assay	NNS	NNS	_	12	conj	_	_
11	,	,	,	,	_	12	punct	_	_
12	and	and	CC	CC	_	4	advmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	mutation	mutation	NN	NN	_	16	compound	_	_
16	screening	screening	NN	NN	_	12	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	denaturing	denature	VBG	VBG	_	16	dep	_	_
19	gradient	gradient	NN	NN	_	21	compound	_	_
20	gel	gel	NN	NN	_	21	compound	_	_
21	electrophoresis	electrophoresis	NN	NN	_	18	dobj	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	receptor-cDNA	receptor-cdna	NN	NN	_	16	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	concentration	concentration	NN	NN	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	as	as	IN	IN	_	6	mark	_	_
6	measured	measure	VBN	VBN	_	14	dep	_	_
7	by	by	IN	IN	_	8	case	_	_
8	staining	stain	VBG	VBG	_	6	advcl	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	steroid	steroid	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	test	test	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	14	punct	_	_
14	varied	vary	VBD	VBD	_	0	root	_	_
15	considerably	considerably	RB	RB	_	14	advmod	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	showed	show	VBD	VBD	_	14	conj	_	_
18	no	no	DT	DT	_	20	neg	_	_
19	clear	clear	JJ	JJ	_	20	amod	_	_
20	correlation	correlation	NN	NN	_	17	dobj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	clinical	clinical	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	7	det	_	_
3	highly	highly	RB	RB	_	4	advmod	_	_
4	sensitive	sensitive	JJ	JJ	_	7	amod	_	_
5	mutation	mutation	NN	NN	_	7	compound	_	_
6	screening	screening	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	1	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	DNA-	dna-	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	steroid-binding	steroid-binding	JJ	JJ	_	10	conj	_	_
14	region	region	NN	NN	_	10	dep	_	_
15	,	,	,	,	_	1	punct	_	_
16	none	none	NN	NN	_	21	nsubj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	treated	treat	VBN	VBN	_	20	amod	_	_
20	patients	patient	NNS	NNS	_	16	nmod	_	_
21	revealed	reveal	VBD	VBD	_	1	parataxis	_	_
22	any	any	DT	DT	_	23	det	_	_
23	mutation	mutation	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	21	punct	_	_
25	suggesting	suggest	VBG	VBG	_	21	advcl	_	_
26	that	that	IN	IN	_	37	mark	_	_
27	the	the	DT	DT	_	29	det	_	_
28	glucocorticoid	glucocorticoid	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	37	nsubjpass	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	CLL	cll	NN	NN	_	33	compound	_	_
33	patients	patient	NNS	NNS	_	29	nmod	_	_
34	tested	test	VBN	VBN	_	33	acl	_	_
35	is	be	VBZ	VBZ	_	37	auxpass	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	altered	alter	VBN	VBN	_	25	ccomp	_	_
38	in	in	IN	IN	_	40	case	_	_
39	these	these	DT	DT	_	40	det	_	_
40	domains	domain	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	one	one	CD	CD	_	3	nummod	_	_
3	individual	individual	NN	NN	_	15	nmod	_	_
4	who	who	WP	WP	_	8	nsubjpass	_	_
5	had	have	VBD	VBD	_	8	aux	_	_
6	not	not	RB	RB	_	8	neg	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	treated	treat	VBN	VBN	_	3	acl:relcl	_	_
9	before	before	IN	IN	_	10	case	_	_
10	analysis	analysis	NN	NN	_	8	nmod	_	_
11	a	a	DT	DT	_	13	det	_	_
12	silent	silent	JJ	JJ	_	13	amod	_	_
13	mutation	mutation	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	one	one	CD	CD	_	19	nummod	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	allele	allele	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	mechanisms	mechanism	NNS	NNS	_	18	nsubj	_	_
6	other	other	JJ	JJ	_	5	cc	_	_
7	than	than	IN	IN	_	6	dep	_	_
8	altered	altered	JJ	JJ	_	9	amod	_	_
9	ligand	ligand	NN	NN	_	5	conj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	receptor	receptor	NN	NN	_	12	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	lack	lack	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	response	response	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	chemotherapy	chemotherapy	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	conclusion	conclusion	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	discussed	discuss	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	relation	relation	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	mechanism	mechanism	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	corticoid	corticoid	NN	NN	_	12	compound	_	_
12	resistance	resistance	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	mouse	mouse	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	human	human	JJ	JJ	_	14	conj	_	_
17	lymphoma	lymphoma	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	dep	_	_
19	in	in	IN	IN	_	20	case	_	_
20	culture	culture	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Cupric	cupric	JJ	JJ	_	2	amod	_	_
2	ion	ion	NN	NN	_	3	nsubj	_	_
3	blocks	block	VBZ	VBZ	_	0	root	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	dobj	_	_
8	through	through	IN	IN	_	9	mark	_	_
9	inhibiting	inhibit	VBG	VBG	_	3	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	signal-induced	signal-induced	JJ	JJ	_	12	amod	_	_
12	phosphorylation	phosphorylation	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	I	i	NN	NN	_	17	compound	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	26	nsubjpass	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	dep	_	_
7	,	,	,	,	_	3	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	regulates	regulate	VBZ	VBZ	_	3	acl:relcl	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	various	various	JJ	JJ	_	14	amod	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	responses	response	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	14	conj	_	_
22	including	include	VBG	VBG	_	23	case	_	_
23	HIV	hiv	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	sequestered	sequester	VBN	VBN	_	0	root	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	cytoplasm	cytoplasm	NN	NN	_	26	nmod	_	_
30	as	as	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	complex	complex	NN	NN	_	26	nmod	_	_
33	with	with	IN	IN	_	39	case	_	_
34	an	a	DT	DT	_	39	det	_	_
35	inhibitory	inhibitory	JJ	JJ	_	39	amod	_	_
36	protein	protein	NN	NN	_	39	compound	_	_
37	I	i	NN	NN	_	39	compound	_	_
38	kappa	kappa	NN	NN	_	39	compound	_	_
39	B	b	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	26	punct	_	_

1	Various	various	JJ	JJ	_	3	amod	_	_
2	extracellular	extracellular	JJ	JJ	_	3	amod	_	_
3	signals	signal	NNS	NNS	_	4	nsubj	_	_
4	induce	induce	VBP	VBP	_	0	root	_	_
5	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	rapid	rapid	JJ	JJ	_	8	amod	_	_
8	degradation	degradation	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	release	release	VB	VB	_	4	advcl	_	_
16	NF	nf	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Cu2+	cu2+	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	inhibit	inhibit	VB	VB	_	3	xcomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activation	activation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	NF	nf	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	7	nmod	_	_
12	induced	induce	VBN	VBN	_	7	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	TPA	tpa	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	or	or	CC	CC	_	14	cc	_	_
19	H2O2	h2o2	NN	NN	_	14	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Deoxycholate	deoxycholate	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	cytoplasmic	cytoplasmic	JJ	JJ	_	6	amod	_	_
6	extract	extract	NN	NN	_	2	nmod	_	_
7	prepared	prepare	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	stimulated	stimulate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Cu2+	cu2+	NN	NN	_	15	nmod	_	_
18	resulted	result	VBD	VBD	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	release	release	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	NF	nf	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	21	nmod	_	_
26	from	from	IN	IN	_	30	case	_	_
27	I	i	NN	NN	_	30	compound	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	alpha	alpha	NN	NN	_	21	nmod	_	_
31	,	,	,	,	_	18	punct	_	_
32	indicating	indicate	VBG	VBG	_	18	xcomp	_	_
33	that	that	IN	IN	_	35	mark	_	_
34	Cu2+	cu2+	NN	NN	_	35	nsubj	_	_
35	interferes	interfere	VBZ	VBZ	_	32	ccomp	_	_
36	with	with	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	dissociation	dissociation	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	46	case	_	_
40	the	the	DT	DT	_	46	det	_	_
41	NF	nf	NN	NN	_	46	compound	_	_
42	kappa	kappa	NN	NN	_	46	compound	_	_
43	B-I	b-i	NN	NN	_	46	compound	_	_
44	kappa	kappa	NN	NN	_	46	compound	_	_
45	B	b	NN	NN	_	46	compound	_	_
46	complex	complex	NN	NN	_	38	nmod	_	_
47	.	.	.	.	_	18	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	phosphorylation	phosphorylation	NN	NN	_	11	nsubjpass	_	_
3	nor	nor	CC	CC	_	2	cc	_	_
4	degradation	degradation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	presence	presence	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Cu2+	cu2+	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Cu2+	cu2+	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	release	release	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF	nf	NN	NN	_	12	compound	_	_
11	kappa	kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	blockade	blockade	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	signal	signal	NN	NN	_	14	nmod	_	_
18	leading	lead	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	I	i	NN	NN	_	26	compound	_	_
24	kappa	kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	dexamethasone	dexamethasone	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	14	case	_	_
10	New	new	NN	NN	_	14	compound	_	_
11	World	world	NN	NN	_	14	compound	_	_
12	primate	primate	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	extracts	extract	NNS	NNS	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	if	if	IN	IN	_	7	mark	_	_
4	New	new	NN	NN	_	6	compound	_	_
5	World	world	NN	NN	_	6	compound	_	_
6	primates	primate	NNS	NNS	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	2	advcl	_	_
8	an	a	DT	DT	_	9	det	_	_
9	inhibitor	inhibitor	NN	NN	_	7	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	influences	influence	VBZ	VBZ	_	9	acl:relcl	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GR	gr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	characteristics	characteristic	NNS	NNS	_	11	dobj	_	_
19	,	,	,	,	_	2	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	examined	examine	VBD	VBD	_	2	parataxis	_	_
22	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	cytosol	cytosol	NN	NN	_	23	nmod	_	_
26	prepared	prepare	VBN	VBN	_	25	acl	_	_
27	from	from	IN	IN	_	30	case	_	_
28	B95-8	b95-8	NN	NN	_	30	compound	_	_
29	lymphoid	lymphoid	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	derived	derive	VBN	VBN	_	30	acl	_	_
33	from	from	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	cotton	cotton	NN	NN	_	37	compound	_	_
36	top	top	NN	NN	_	37	compound	_	_
37	tamarin	tamarin	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	Saguinus	saguinus	FW	FW	_	40	compound	_	_
40	oedipus	oedipus	FW	FW	_	37	dep	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	25	punct	_	_
43	in	in	IN	IN	_	44	case	_	_
44	combination	combination	NN	NN	_	25	nmod	_	_
45	with	with	IN	IN	_	46	case	_	_
46	cytosol	cytosol	NN	NN	_	44	nmod	_	_
47	prepared	prepare	VBN	VBN	_	46	acl	_	_
48	from	from	IN	IN	_	49	case	_	_
49	human	human	JJ	JJ	_	47	nmod	_	_
50	or	or	CC	CC	_	49	cc	_	_
51	rat	rat	NN	NN	_	49	conj	_	_
52	tissues	tissue	NNS	NNS	_	49	dep	_	_
53	.	.	.	.	_	2	punct	_	_

1	B95-8	b95-8	NN	NN	_	2	compound	_	_
2	cytosol	cytosol	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	P	p	NN	NN	_	7	dep	_	_
10	&lt;	&lt;	JJR	JJR	_	9	amod	_	_
11	0.01	0.01	CD	CD	_	10	dep	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	mixed	mix	VBN	VBN	_	3	advcl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	cytosol	cytosol	NN	NN	_	14	nmod	_	_
17	prepared	prepare	VBN	VBN	_	16	acl	_	_
18	from	from	IN	IN	_	24	case	_	_
19	either	either	CC	CC	_	24	cc:preconj	_	_
20	a	a	DT	DT	_	24	det	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	lymphoid	lymphoid	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	17	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HL	hl	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	or	or	CC	CC	_	24	cc	_	_
29	rat	rat	NN	NN	_	30	compound	_	_
30	thymus	thymus	NN	NN	_	24	conj	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	heat	heat	NN	NN	_	6	nmod:npmod	_	_
6	labile	labile	JJ	JJ	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	trypsin	trypsin	NN	NN	_	9	nmod:npmod	_	_
9	sensitive	sensitive	JJ	JJ	_	6	conj	_	_
10	.	.	.	.	_	6	punct	_	_

1	Peak	peak	JJ	JJ	_	3	amod	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	150-200	150-200	CD	CD	_	9	dep	_	_
9	kd	kd	NN	NN	_	10	dep	_	_
10	fractions	fraction	NNS	NNS	_	5	nmod	_	_
11	after	after	IN	IN	_	14	case	_	_
12	Sephacryl	sephacryl	NN	NN	_	14	compound	_	_
13	G-200	g-200	NN	NN	_	14	compound	_	_
14	ultrafiltration	ultrafiltration	NN	NN	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Scatchard	scatchard	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	2	nmod	_	_
6	using	use	VBG	VBG	_	2	acl	_	_
7	mixed	mixed	JJ	JJ	_	8	amod	_	_
8	cytosol	cytosol	NN	NN	_	6	dobj	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	15	det	_	_
11	diminished	diminish	VBN	VBN	_	15	amod	_	_
12	GR	gr	NN	NN	_	15	compound	_	_
13	apparent	apparent	JJ	JJ	_	15	amod	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	affinity	affinity	NN	NN	_	9	dobj	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	compared	compare	VBN	VBN	_	9	advcl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	HL	hl	NN	NN	_	20	compound	_	_
20	cytosol	cytosol	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Kinetic	kinetic	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	6	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	mixed	mixed	JJ	JJ	_	5	amod	_	_
5	cytosol	cytosol	NN	NN	_	3	dobj	_	_
6	indicated	indicate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	B95-8	b95-8	NN	NN	_	9	compound	_	_
9	cytosol	cytosol	NN	NN	_	12	nsubj	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	affect	affect	VB	VB	_	6	ccomp	_	_
13	the	the	DT	DT	_	16	det	_	_
14	apparent	apparent	JJ	JJ	_	16	amod	_	_
15	dissociation	dissociation	NN	NN	_	16	compound	_	_
16	rate	rate	NN	NN	_	12	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	B95-8	b95-8	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	contain	contain	VBP	VBP	_	3	ccomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	competitive	competitive	JJ	JJ	_	10	amod	_	_
10	inhibitor	inhibitor	NN	NN	_	7	dobj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	prevents	prevent	VBZ	VBZ	_	10	acl:relcl	_	_
13	binding	binding	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	dexamethasone	dexamethasone	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	cognate	cognate	JJ	JJ	_	19	amod	_	_
19	receptor	receptor	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	myeloid	myeloid	JJ	JJ	_	5	amod	_	_
3	zinc	zinc	NN	NN	_	5	compound	_	_
4	finger	finger	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	9	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	MZF-1	mzf-1	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	regulates	regulate	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CD34	cd34	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	9	dobj	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	9	advmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	MZF-1	mzf-1	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	C2H2	c2h2	NN	NN	_	7	compound	_	_
5	zinc	zinc	NN	NN	_	7	compound	_	_
6	finger	finger	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	0	root	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	putative	putative	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	regulator	regulator	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	MZF-1	mzf-1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	13	13	CD	CD	_	8	nummod	_	_
6	C2H2	c2h2	NN	NN	_	8	compound	_	_
7	zinc	zinc	NN	NN	_	8	compound	_	_
8	fingers	finger	NNS	NNS	_	4	dobj	_	_
9	arranged	arrange	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	14	case	_	_
11	bipartite	bipartite	JJ	JJ	_	14	amod	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	domains	domain	NNS	NNS	_	9	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	zinc	zinc	NN	NN	_	17	compound	_	_
17	fingers	finger	NNS	NNS	_	15	dobj	_	_
18	through	through	IN	IN	_	19	case	_	_
19	4	4	CD	CD	_	17	nmod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	,	,	,	,	_	17	punct	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	carboxy-terminus	carboxy-terminus	NN	NN	_	17	conj	_	_
25	,	,	,	,	_	17	punct	_	_
26	5	5	CD	CD	_	17	conj	_	_
27	through	through	IN	IN	_	28	case	_	_
28	13	13	CD	CD	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	DNA	dna	NN	NN	_	8	compound	_	_
6	consensus	consensus	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	3	dobj	_	_
9	recognized	recognize	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	two	two	CD	CD	_	15	nummod	_	_
13	DNA	dna	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	domains	domain	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	assess	assess	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	function	function	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	MZF-1	mzf-1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	the	the	DT	DT	_	14	det	_	_
11	full-length	full-length	JJ	JJ	_	14	amod	_	_
12	MZF-1	mzf-1	NN	NN	_	14	compound	_	_
13	coding	coding	NN	NN	_	14	compound	_	_
14	region	region	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	fused	fuse	VBN	VBN	_	2	parataxis	_	_
17	to	to	TO	TO	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	DNA	dna	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	domain	domain	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	yeast	yeast	NN	NN	_	26	compound	_	_
25	transactivator	transactivator	NN	NN	_	26	compound	_	_
26	GAL4	gal4	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	vector	vector	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	cotransfected	cotransfect	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	15	case	_	_
7	the	the	DT	DT	_	15	det	_	_
8	chloramphenicol	chloramphenicol	NN	NN	_	15	compound	_	_
9	acetyl	acetyl	NN	NN	_	15	compound	_	_
10	transferase	transferase	NN	NN	_	15	compound	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	CAT	cat	NN	NN	_	15	compound	_	_
13	)	)	-RRB-	-RRB-	_	15	punct	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	5	nmod	_	_
16	regulated	regulate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	thymidine	thymidine	NN	NN	_	21	compound	_	_
20	kinase	kinase	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	16	nmod	_	_
22	containing	contain	VBG	VBG	_	21	acl	_	_
23	GAL4	gal4	NN	NN	_	26	compound	_	_
24	DNA	dna	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	22	dobj	_	_
27	into	into	IN	IN	_	29	case	_	_
28	NIH	nih	NN	NN	_	29	compound	_	_
29	3T3	3t3	NN	NN	_	5	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	293	293	CD	CD	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	K562	k562	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	Jurkat	jurkat	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	29	conj	_	_
39	.	.	.	.	_	5	punct	_	_

1	MZF-1	mzf-1	NN	NN	_	2	nsubj	_	_
2	represses	repress	VBZ	VBZ	_	0	root	_	_
3	CAT	cat	NN	NN	_	5	compound	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	dobj	_	_
7	via	via	IN	IN	_	10	case	_	_
8	GAL4	gal4	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	2	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	nonhematopoietic	nonhematopoietic	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	10	nmod	_	_
16	NIH	nih	NN	NN	_	17	compound	_	_
17	3T3	3t3	NN	NN	_	15	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	293	293	CD	CD	_	17	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	MZF-1	mzf-1	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	CAT	cat	NN	NN	_	8	compound	_	_
7	reporter	reporter	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	9	nmod	_	_
15	K562	k562	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Jurkat	jurkat	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	MZF-1	mzf-1	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	promoters	promoter	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	expressed	express	VBN	VBN	_	12	acl	_	_
14	during	during	IN	IN	_	16	case	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	including	include	VBG	VBG	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD34	cd34	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	9	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	MZF-1	mzf-1	NN	NN	_	3	compound	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	this	this	DT	DT	_	8	det	_	_
6	physiologically	physiologically	RB	RB	_	8	advmod	_	_
7	relevant	relevant	JJ	JJ	_	8	amod	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	assessed	assess	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	hematopoietic	hematopoietic	JJ	JJ	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nonhematopoietic	nonhematopoietic	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	conj	_	_
18	.	.	.	.	_	10	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	3	amod	_	_
2	MZF-1	mzf-1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubj	_	_
4	specifically	specifically	RB	RB	_	5	advmod	_	_
5	binds	bind	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	consensus	consensus	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	5	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD34	cd34	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	mobility	mobility	NN	NN	_	18	compound	_	_
17	shift	shift	NN	NN	_	18	compound	_	_
18	assays	assay	NNS	NNS	_	5	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	MZF-1	mzf-1	NN	NN	_	3	compound	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	vectors	vector	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	cotransfected	cotransfect	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	luciferase	luciferase	NN	NN	_	10	compound	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	plasmids	plasmid	NNS	NNS	_	5	nmod	_	_
11	regulated	regulate	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CD34	cd34	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	into	into	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	nonhematopoietic	nonhematopoietic	JJ	JJ	_	5	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	hematopoietic	hematopoietic	JJ	JJ	_	18	conj	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	7	case	_	_
2	with	with	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	heterologous	heterologous	JJ	JJ	_	7	amod	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	10	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	MZF-1	mzf-1	NN	NN	_	10	nsubj	_	_
10	represses	repress	VBZ	VBZ	_	0	root	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	nonhematopoietic	nonhematopoietic	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	activates	activate	VBZ	VBZ	_	10	conj	_	_
20	expression	expression	NN	NN	_	19	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CD34	cd34	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	1	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	intact	intact	JJ	JJ	_	18	amod	_	_
16	MZF-1	mzf-1	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	type-specific	type-specific	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CD34	cd34	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	MZF-1	mzf-1	NN	NN	_	4	nmod	_	_
11	suggests	suggest	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	tissue-specific	tissue-specific	JJ	JJ	_	16	amod	_	_
16	regulators/adapters	regulators/adapters	NNS	NNS	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	differential	differential	JJ	JJ	_	20	amod	_	_
19	MZF-1	mzf-1	NN	NN	_	20	compound	_	_
20	modifications	modification	NNS	NNS	_	16	conj	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	determine	determine	VBP	VBP	_	16	acl:relcl	_	_
23	MZF-1	mzf-1	NN	NN	_	26	compound	_	_
24	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	function	function	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	11	punct	_	_

1	Bik	bik	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	death-inducing	death-inducing	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	1	appos	_	_
7	shares	share	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	distinct	distinct	JJ	JJ	_	11	amod	_	_
10	sequence	sequence	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	7	dobj	_	_
12	with	with	IN	IN	_	15	case	_	_
13	Bcl-2	bcl-2	NN	NN	_	15	compound	_	_
14	family	family	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	7	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	interacts	interact	VBZ	VBZ	_	7	conj	_	_
18	with	with	IN	IN	_	19	case	_	_
19	viral	viral	JJ	JJ	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	cellular	cellular	JJ	JJ	_	23	amod	_	_
22	survival-promoting	survival-promoting	JJ	JJ	_	23	amod	_	_
23	proteins	protein	NNS	NNS	_	19	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	survival-promoting	survival-promoting	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Bcl-2	bcl-2	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	proteins	protein	NNS	NNS	_	7	nmod	_	_
10	appears	appear	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	modulated	modulate	VBN	VBN	_	10	xcomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	interactions	interaction	NNS	NNS	_	13	nmod	_	_
16	between	between	IN	IN	_	19	case	_	_
17	various	various	JJ	JJ	_	19	amod	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	Bik	bik	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	interacts	interact	VBZ	VBZ	_	7	acl:relcl	_	_
13	with	with	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	cellular	cellular	JJ	JJ	_	17	amod	_	_
16	survival-promoting	survival-promoting	JJ	JJ	_	17	amod	_	_
17	proteins	protein	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	Bcl-2	bcl-2	NN	NN	_	17	appos	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Bcl-xL	bcl-xl	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	as	as	RB	RB	_	17	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	the	the	DT	DT	_	29	det	_	_
27	viral	viral	JJ	JJ	_	29	amod	_	_
28	survival-promoting	survival-promoting	JJ	JJ	_	29	amod	_	_
29	proteins	protein	NNS	NNS	_	17	conj	_	_
30	,	,	,	,	_	29	punct	_	_
31	Epstein	epstein	NN	NN	_	33	compound	_	_
32	Barr	barr	NN	NN	_	33	compound	_	_
33	virus-BHRF1	virus-bhrf1	NN	NN	_	29	appos	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	adenovirus	adenovirus	NN	NN	_	37	compound	_	_
36	E1B-19	e1b-19	NN	NN	_	37	compound	_	_
37	kDa	kda	NN	NN	_	33	conj	_	_
38	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	Bik	bik	NN	NN	_	7	nsubj	_	_
7	promotes	promote	VBZ	VBZ	_	0	root	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	death	death	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	manner	manner	NN	NN	_	7	nmod	_	_
13	similar	similar	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	death-promoting	death-promoting	JJ	JJ	_	17	amod	_	_
17	members	member	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Bcl-2	bcl-2	NN	NN	_	21	compound	_	_
21	family	family	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	Bax	bax	NN	NN	_	17	appos	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Bak	bak	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	death-promoting	death-promoting	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Bik	bik	NN	NN	_	3	nmod	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	suppressed	suppress	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	coexpression	coexpression	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Bcl-2	bcl-2	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	Bcl-XL	bcl-xl	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	EBV-BHRF1	ebv-bhrf1	NN	NN	_	12	conj	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	E1B-19	e1b-19	NN	NN	_	19	compound	_	_
19	kDa	kda	NN	NN	_	12	conj	_	_
20	proteins	protein	NNS	NNS	_	12	dep	_	_
21	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
22	that	that	IN	IN	_	28	mark	_	_
23	Bik	bik	NN	NN	_	28	nsubj	_	_
24	may	may	MD	MD	_	28	aux	_	_
25	be	be	VB	VB	_	28	cop	_	_
26	a	a	DT	DT	_	28	det	_	_
27	common	common	JJ	JJ	_	28	amod	_	_
28	target	target	NN	NN	_	21	ccomp	_	_
29	for	for	IN	IN	_	31	case	_	_
30	both	both	CC	CC	_	31	cc:preconj	_	_
31	cellular	cellular	JJ	JJ	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	viral	viral	JJ	JJ	_	31	conj	_	_
34	anti-apoptotic	anti-apoptotic	JJ	JJ	_	35	amod	_	_
35	proteins	protein	NNS	NNS	_	31	dep	_	_
36	.	.	.	.	_	8	punct	_	_

1	While	while	IN	IN	_	2	mark	_	_
2	Bik	bik	NN	NN	_	23	advcl	_	_
3	does	do	VBZ	VBZ	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	show	show	VB	VB	_	2	dep	_	_
6	overt	overt	JJ	JJ	_	7	amod	_	_
7	homology	homology	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	BH1	bh1	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	BH2	bh2	NN	NN	_	10	conj	_	_
13	conserved	conserved	JJ	JJ	_	14	amod	_	_
14	domains	domain	NNS	NNS	_	10	dep	_	_
15	characteristic	characteristic	JJ	JJ	_	10	amod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Bcl-2	bcl-2	NN	NN	_	19	compound	_	_
19	family	family	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	does	do	VBZ	VBZ	_	23	aux	_	_
23	share	share	VB	VB	_	0	root	_	_
24	a	a	DT	DT	_	28	det	_	_
25	9	9	CD	CD	_	28	nummod	_	_
26	amino	amino	NN	NN	_	28	compound	_	_
27	acid	acid	NN	NN	_	28	compound	_	_
28	domain	domain	NN	NN	_	23	dobj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	BH3	bh3	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	with	with	IN	IN	_	33	case	_	_
33	Bax	bax	NN	NN	_	23	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Bak	bak	NN	NN	_	33	conj	_	_
36	which	which	WDT	WDT	_	41	nsubj	_	_
37	may	may	MD	MD	_	41	aux	_	_
38	be	be	VB	VB	_	41	cop	_	_
39	a	a	DT	DT	_	41	det	_	_
40	critical	critical	JJ	JJ	_	41	amod	_	_
41	determinant	determinant	NN	NN	_	23	dep	_	_
42	for	for	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	death-promoting	death-promoting	JJ	JJ	_	45	amod	_	_
45	activity	activity	NN	NN	_	41	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	these	these	DT	DT	_	48	det	_	_
48	proteins	protein	NNS	NNS	_	45	nmod	_	_
49	.	.	.	.	_	23	punct	_	_

1	Initiation	initiation	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	repressor	repressor	NN	NN	_	23	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	factor	factor	NN	NN	_	3	appos	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	binds	bind	VBZ	VBZ	_	6	acl:relcl	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	initiation	initiation	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	histone	histone	NN	NN	_	18	compound	_	_
17	h5	h5	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	is	be	VBZ	VBZ	_	23	cop	_	_
21	a	a	DT	DT	_	23	det	_	_
22	glycosylated	glycosylate	VBN	VBN	_	23	amod	_	_
23	member	member	NN	NN	_	0	root	_	_
24	of	of	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	family	family	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	growth	growth	NN	NN	_	30	compound	_	_
30	regulators	regulator	NNS	NNS	_	26	nmod	_	_
31	-LSB-	-lsb-	-LRB-	-LRB-	_	32	punct	_	_
32	corrected	corrected	JJ	JJ	_	23	dep	_	_
33	-RSB-	-rsb-	-RRB-	-RRB-	_	32	punct	_	_
34	-LSB-	-lsb-	-LRB-	-LRB-	_	37	punct	_	_
35	published	publish	VBN	VBN	_	36	amod	_	_
36	erratum	erratum	NN	NN	_	37	nsubj	_	_
37	appears	appear	VBZ	VBZ	_	23	parataxis	_	_
38	in	in	IN	IN	_	43	case	_	_
39	Mol	Mol	NNP	NNP	_	43	compound	_	_
40	Cell	Cell	NNP	NNP	_	43	compound	_	_
41	Biol	Biol	NNP	NNP	_	43	compound	_	_
42	1996	1996	CD	CD	_	43	nummod	_	_
43	Feb	Feb	NNP	NNP	_	37	nmod	_	_
44	;	;	:	:	_	43	punct	_	_
45	16	16	CD	CD	_	47	nummod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	2	2	CD	CD	_	43	dep	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	:	:	:	:	_	43	punct	_	_
50	735	735	CD	CD	_	43	dep	_	_
51	-RSB-	-rsb-	-RRB-	-RRB-	_	37	punct	_	_

1	Initiation	initiation	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	repressor	repressor	NN	NN	_	14	nsubj	_	_
4	-LSB-	-lsb-	-LRB-	-LRB-	_	5	punct	_	_
5	corrected	correct	VBN	VBN	_	3	dep	_	_
6	-RSB-	-rsb-	-RRB-	-RRB-	_	5	punct	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IBR	ibr	NN	NN	_	3	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	chicken	chicken	NN	NN	_	14	compound	_	_
13	erythrocyte	erythrocyte	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	0	root	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	apparent	apparent	JJ	JJ	_	18	amod	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	mass	mass	NN	NN	_	14	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	70	70	CD	CD	_	22	compound	_	_
21	to	to	TO	TO	_	22	dep	_	_
22	73	73	CD	CD	_	23	nummod	_	_
23	kDa	kda	NN	NN	_	18	appos	_	_
24	)	)	-RRB-	-RRB-	_	18	punct	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	binds	bind	VBZ	VBZ	_	14	acl:relcl	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	sequences	sequence	NNS	NNS	_	26	nmod	_	_
30	spanning	span	VBG	VBG	_	29	acl	_	_
31	the	the	DT	DT	_	34	det	_	_
32	transcription	transcription	NN	NN	_	34	compound	_	_
33	initiation	initiation	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	30	dobj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	histone	histone	NN	NN	_	39	compound	_	_
38	h5	h5	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	34	nmod	_	_
40	,	,	,	,	_	26	punct	_	_
41	repressing	repress	VBG	VBG	_	26	xcomp	_	_
42	its	its	PRP$	PRP$	_	43	nmod:poss	_	_
43	transcription	transcription	NN	NN	_	41	dobj	_	_
44	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	variety	variety	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	including	include	VBG	VBG	_	10	case	_	_
8	transformed	transform	VBN	VBN	_	10	amod	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	precursors	precursor	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	do	do	VBP	VBP	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	have	have	VB	VB	_	0	root	_	_
15	IBR	ibr	NN	NN	_	14	dobj	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	a	a	DT	DT	_	18	det	_	_
18	factor	factor	NN	NN	_	15	conj	_	_
19	referred	refer	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	19	nmod	_	_
21	as	as	IN	IN	_	22	case	_	_
22	IBF	ibf	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	68	68	CD	CD	_	26	compound	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	70	70	CD	CD	_	27	nummod	_	_
27	kDa	kda	NN	NN	_	22	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	recognizes	recognize	VBZ	VBZ	_	18	acl:relcl	_	_
31	the	the	DT	DT	_	34	det	_	_
32	same	same	JJ	JJ	_	34	amod	_	_
33	IBR	ibr	NN	NN	_	34	compound	_	_
34	sites	site	NNS	NNS	_	30	dobj	_	_
35	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	IBR	ibr	NN	NN	_	6	compound	_	_
6	cDNA	cdna	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	studied	study	VBN	VBN	_	3	conj	_	_
9	the	the	DT	DT	_	10	det	_	_
10	relationship	relationship	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IBR	ibr	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IBF	ibf	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	IBR	ibr	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	503-amino-acid-long	503-amino-acid-long	JJ	JJ	_	6	amod	_	_
5	acidic	acidic	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	0	root	_	_
7	which	which	WDT	WDT	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	99.0	99.0	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	11	nmod:npmod	_	_
11	identical	identical	JJ	JJ	_	6	acl:relcl	_	_
12	to	to	TO	TO	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	recently	recently	RB	RB	_	15	advmod	_	_
15	reported	report	VBN	VBN	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	NRF-1/alpha-Pal	nrf-1/alpha-pal	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	11	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	highly	highly	RB	RB	_	21	advmod	_	_
21	related	related	JJ	JJ	_	11	conj	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	invertebrate	invertebrate	JJ	JJ	_	26	amod	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	21	nmod	_	_
27	P3A2	p3a2	NN	NN	_	26	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	erected	erected	JJ	JJ	_	32	amod	_	_
30	wing	wing	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	product	product	NN	NN	_	27	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	EWG	ewg	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	IBR	ibr	NN	NN	_	12	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IBF	ibf	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	12	cop	_	_
9	most	most	RBS	RBS	_	11	advmod	_	_
10	likely	likely	RB	RB	_	11	advmod	_	_
11	identical	identical	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	3	ccomp	_	_
13	,	,	,	,	_	12	punct	_	_
14	differing	differ	VBG	VBG	_	12	advcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	degree	degree	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	glycosylation	glycosylation	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	aspects	aspect	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IBR/F	ibr/f	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	shown	show	VBN	VBN	_	3	conj	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	factor	factor	NN	NN	_	14	nsubj	_	_
14	associates	associate	VBZ	VBZ	_	10	ccomp	_	_
15	as	as	IN	IN	_	17	case	_	_
16	stable	stable	JJ	JJ	_	17	amod	_	_
17	homodimers	homodimer	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	dimer	dimer	NN	NN	_	26	nsubj	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	the	the	DT	DT	_	26	det	_	_
24	relevant	relevant	JJ	JJ	_	26	amod	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	species	species	NNS	NNS	_	14	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	evolutionarily	evolutionarily	RB	RB	_	3	advmod	_	_
3	conserved	conserve	VBN	VBN	_	5	amod	_	_
4	N-terminal	n-terminal	JJ	JJ	_	5	amod	_	_
5	half	half	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IBR/F	ibr/f	NN	NN	_	5	nmod	_	_
8	harbors	harbor	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	DNA-binding/dimerization	dna-binding/dimerization	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	8	dobj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	outer	outer	JJ	JJ	_	14	amod	_	_
14	limits	limit	NNS	NNS	_	11	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	127	127	CD	CD	_	18	compound	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	283	283	CD	CD	_	14	appos	_	_
19	)	)	-RRB-	-RRB-	_	14	punct	_	_
20	,	,	,	,	_	11	punct	_	_
21	one	one	CD	CD	_	11	conj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	several	several	JJ	JJ	_	21	conj	_	_
24	casein	casein	NN	NN	_	27	compound	_	_
25	kinase	kinase	NN	NN	_	27	compound	_	_
26	II	ii	CD	CD	_	27	nummod	_	_
27	sites	site	NNS	NNS	_	21	dep	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	37	37	CD	CD	_	31	compound	_	_
30	to	to	TO	TO	_	31	dep	_	_
31	67	67	CD	CD	_	21	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	11	punct	_	_
34	and	and	CC	CC	_	11	cc	_	_
35	a	a	DT	DT	_	39	det	_	_
36	bipartite	bipartite	JJ	JJ	_	39	amod	_	_
37	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
38	localization	localization	NN	NN	_	39	compound	_	_
39	signal	signal	NN	NN	_	11	conj	_	_
40	(	(	-LRB-	-LRB-	_	43	punct	_	_
41	89	89	CD	CD	_	43	compound	_	_
42	to	to	TO	TO	_	43	dep	_	_
43	106	106	CD	CD	_	39	dep	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	which	which	WDT	WDT	_	46	nsubj	_	_
46	appears	appear	VBZ	VBZ	_	39	acl:relcl	_	_
47	to	to	TO	TO	_	49	mark	_	_
48	be	be	VB	VB	_	49	cop	_	_
49	necessary	necessary	JJ	JJ	_	46	xcomp	_	_
50	for	for	IN	IN	_	52	case	_	_
51	nuclear	nuclear	JJ	JJ	_	52	amod	_	_
52	targeting	targeting	NN	NN	_	49	nmod	_	_
53	.	.	.	.	_	8	punct	_	_

1	Binding	bind	VBG	VBG	_	3	amod	_	_
2	site	site	NN	NN	_	3	compound	_	_
3	selection	selection	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	alternating	alternate	VBG	VBG	_	9	amod	_	_
8	RCGCRYGCGY	rcgcrygcgy	NN	NN	_	9	compound	_	_
9	consensus	consensus	NN	NN	_	10	nsubj	_	_
10	constitutes	constitute	VBZ	VBZ	_	4	ccomp	_	_
11	high-affinity	high-affinity	JJ	JJ	_	14	amod	_	_
12	IBR/F	ibr/f	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	sites	site	NNS	NNS	_	10	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	that	that	IN	IN	_	24	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	direct-repeat	direct-repeat	JJ	JJ	_	19	amod	_	_
19	palindrome	palindrome	NN	NN	_	24	nsubj	_	_
20	TGCGCATGCGCA	tgcgcatgcgca	NN	NN	_	19	dep	_	_
21	is	be	VBZ	VBZ	_	24	cop	_	_
22	the	the	DT	DT	_	24	det	_	_
23	optimal	optimal	JJ	JJ	_	24	amod	_	_
24	site	site	NN	NN	_	10	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	survey	survey	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	genes	gene	NNS	NNS	_	2	nmod	_	_
5	potentially	potentially	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	4	acl	_	_
7	by	by	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	family	family	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	factors	factor	NNS	NNS	_	9	nmod	_	_
12	primarily	primarily	RB	RB	_	13	advmod	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	genes	gene	NNS	NNS	_	13	dobj	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	growth-related	growth-related	JJ	JJ	_	18	amod	_	_
18	metabolism	metabolism	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Correlation	correlation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	differentiation-inducing	differentiation-inducing	JJ	JJ	_	4	amod	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	retinoids	retinoid	NNS	NNS	_	4	nmod	_	_
7	on	on	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	leukemia	leukemia	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	4	nmod	_	_
12	HL-60	hl-60	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NB4	nb4	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	1	punct	_	_

1	Retinoids	retinoid	NNS	NNS	_	20	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	including	include	VBG	VBG	_	5	case	_	_
4	all-trans-retinoic	all-trans-retinoic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	isomers	isomer	NNS	NNS	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	fifty	fifty	CD	CD	_	13	nummod	_	_
12	synthetic	synthetic	JJ	JJ	_	13	amod	_	_
13	retinoids	retinoid	NNS	NNS	_	5	conj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	retinobenzoic	retinobenzoic	JJ	JJ	_	16	amod	_	_
16	acids	acid	NNS	NNS	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	1	punct	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	tested	test	VBN	VBN	_	0	root	_	_
21	for	for	IN	IN	_	23	case	_	_
22	differentiation-inducing	differentiation-inducing	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	on	on	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	leukemia	leukemia	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	23	nmod	_	_
29	HL-60	hl-60	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	NB4	nb4	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	good	good	JJ	JJ	_	4	amod	_	_
3	linear	linear	NN	NN	_	4	compound	_	_
4	correlation	correlation	NN	NN	_	30	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	with	with	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	r	r	NN	NN	_	9	compound	_	_
9	value	value	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	0.91	0.91	CD	CD	_	9	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	between	between	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	ED50	ed50	NN	NN	_	16	compound	_	_
16	values	value	NNS	NNS	_	4	nmod	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	differentiation-inducing	differentiation-inducing	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	towards	towards	IN	IN	_	23	case	_	_
22	HL-60	hl-60	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	that	that	DT	DT	_	20	conj	_	_
26	towards	towards	IN	IN	_	28	case	_	_
27	NB4	nb4	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	found	find	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor-IL6	factor-il6	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Positive	positive	JJ	JJ	_	4	amod	_	_
2	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
3	element	element	NN	NN	_	4	compound	_	_
4	I	i	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PRE-I	pre-i	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	strong	strong	JJ	JJ	_	12	amod	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	0	root	_	_
13	essential	essential	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	expression	expression	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	IL-4	il-4	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	2	dobj	_	_
5	binding	bind	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	7	case	_	_
7	PRE-I	pre-i	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	screened	screen	VBD	VBD	_	2	parataxis	_	_
11	a	a	DT	DT	_	14	det	_	_
12	cDNA	cdna	NN	NN	_	14	compound	_	_
13	expression	expression	NN	NN	_	14	compound	_	_
14	library	library	NN	NN	_	10	dobj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	Jurkat	jurkat	NN	NN	_	18	compound	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	isolated	isolate	VBD	VBD	_	10	conj	_	_
21	a	a	DT	DT	_	23	det	_	_
22	cDNA	cdna	NN	NN	_	23	compound	_	_
23	encoding	encoding	NN	NN	_	20	dobj	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	factor	factor	NN	NN	_	23	dep	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	NF	nf	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	-IL6	-il6	NN	NN	_	23	dep	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	also	also	RB	RB	_	32	dep	_	_
32	known	know	VBN	VBN	_	23	dep	_	_
33	as	as	IN	IN	_	35	case	_	_
34	C/EBP	c/ebp	NN	NN	_	35	compound	_	_
35	beta	beta	NN	NN	_	32	nmod	_	_
36	)	)	-RRB-	-RRB-	_	32	punct	_	_
37	.	.	.	.	_	2	punct	_	_

1	NF-IL6	nf-il6	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	Jurkat	jurkat	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	mouse	mouse	NN	NN	_	15	compound	_	_
14	Th2	th2	NN	NN	_	15	compound	_	_
15	clone	clone	NN	NN	_	9	conj	_	_
16	D10	d10	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	9	punct	_	_
18	but	but	CC	CC	_	9	cc	_	_
19	not	not	RB	RB	_	22	neg	_	_
20	in	in	IN	IN	_	22	case	_	_
21	Th1	th1	NN	NN	_	22	compound	_	_
22	clone	clone	NN	NN	_	9	conj	_	_
23	29	29	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	4	punct	_	_

1	rNF-IL6	rnf-il6	NN	NN	_	6	nsubjpass	_	_
2	expressed	express	VBN	VBN	_	1	acl	_	_
3	in	in	IN	IN	_	4	case	_	_
4	bacteria	bacterium	NNS	NNS	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	bind	bind	VB	VB	_	6	xcomp	_	_
10	to	to	TO	TO	_	11	case	_	_
11	PRE-I	pre-i	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	PRE-I	pre-i	NN	NN	_	2	nsubj	_	_
2	forms	form	VBZ	VBZ	_	0	root	_	_
3	multiple	multiple	JJ	JJ	_	5	amod	_	_
4	DNA-protein	dna-protein	NN	NN	_	5	compound	_	_
5	complexes	complex	NNS	NNS	_	2	dobj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	extracts	extract	NNS	NNS	_	2	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Some	some	DT	DT	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	complexes	complex	NNS	NNS	_	1	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	contain	contain	VB	VB	_	6	xcomp	_	_
9	NF-IL6	nf-il6	NN	NN	_	8	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	using	use	VBG	VBG	_	6	advcl	_	_
12	anti-C/EBP	anti-c/ebp	JJ	JJ	_	14	amod	_	_
13	beta	beta	NN	NN	_	14	compound	_	_
14	Abs	ab	NNS	NNS	_	11	dobj	_	_
15	.	.	.	.	_	6	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-IL6	nf-il6	NN	NN	_	1	nmod	_	_
4	enhanced	enhance	VBD	VBD	_	0	root	_	_
5	expression	expression	NN	NN	_	4	iobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	chloramphenicol	chloramphenicol	NN	NN	_	12	compound	_	_
9	acetyl	acetyl	JJ	JJ	_	12	amod	_	_
10	transferase	transferase	NN	NN	_	12	compound	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	5	nmod	_	_
13	linked	link	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	PRE-I-thymidine	pre-i-thymidine	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	13	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	22	det	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	IL-4	il-4	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	17	conj	_	_
23	more	more	JJR	JJR	_	4	dobj	_	_
24	than	than	IN	IN	_	23	amod	_	_
25	10-fold	10-fold	RB	RB	_	23	advmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	Jurkat	jurkat	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	4	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Promoter	promoter	NN	NN	_	3	compound	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	two	two	CD	CD	_	9	nummod	_	_
6	additional	additional	JJ	JJ	_	9	amod	_	_
7	NF-IL6	nf-il6	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	4	dobj	_	_
10	located	located	JJ	JJ	_	9	amod	_	_
11	at	at	IN	IN	_	12	case	_	_
12	positions	position	NNS	NNS	_	10	nmod	_	_
13	-44	-44	CD	CD	_	15	compound	_	_
14	to	to	TO	TO	_	15	dep	_	_
15	-36	-36	CD	CD	_	12	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	C/EBP	c/ebp	NN	NN	_	15	appos	_	_
18	proximal	proximal	JJ	JJ	_	17	amod	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	-87	-87	CD	CD	_	23	compound	_	_
22	to	to	TO	TO	_	23	dep	_	_
23	-79	-79	CD	CD	_	12	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	C/EBP	c/ebp	NN	NN	_	23	appos	_	_
26	medial	medial	JJ	JJ	_	25	amod	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	,	,	,	,	_	10	punct	_	_
29	respectively	respectively	RB	RB	_	10	advmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	NF-IL6	nf-il6	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	IL-4	il-4	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Coexpression	coexpression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	/Rel	/rel	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Sp1	sp1	NN	NN	_	5	conj	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	dep	_	_
10	in	in	IN	IN	_	18	case	_	_
11	human	human	JJ	JJ	_	18	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
13	virus	virus	NN	NN	_	18	compound	_	_
14	1-induced	1-induced	JJ	JJ	_	18	amod	_	_
15	,	,	,	,	_	18	punct	_	_
16	dendritic	dendritic	JJ	JJ	_	18	amod	_	_
17	cell-T-cell	cell-t-cell	NN	NN	_	18	compound	_	_
18	syncytia	syncytia	NN	NN	_	1	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Productive	productive	JJ	JJ	_	2	amod	_	_
2	infection	infection	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
9	virus	virus	NN	NN	_	2	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HIV-1	hiv-1	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	typically	typically	RB	RB	_	15	advmod	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	21	nsubjpass	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	stimulated	stimulate	VBN	VBN	_	15	ccomp	_	_
22	with	with	IN	IN	_	23	case	_	_
23	antigens	antigen	NNS	NNS	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	mitogens	mitogen	NNS	NNS	_	23	conj	_	_
26	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	requirement	requirement	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	attributed	attribute	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	8	nmod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	12	dep	_	_
15	,	,	,	,	_	12	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	synergizes	synergize	VBZ	VBZ	_	12	acl:relcl	_	_
18	with	with	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	constitutive	constitutive	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	17	nmod	_	_
23	Sp1	sp1	NN	NN	_	22	dep	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	drive	drive	VB	VB	_	17	xcomp	_	_
26	the	the	DT	DT	_	28	det	_	_
27	HIV-1	hiv-1	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	25	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	vigorous	vigorous	JJ	JJ	_	8	amod	_	_
8	replication	replication	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	HIV-1	hiv-1	NN	NN	_	8	nmod	_	_
11	takes	take	VBZ	VBZ	_	5	ccomp	_	_
12	place	place	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	nonactivated	nonactivated	JJ	JJ	_	17	amod	_	_
15	memory	memory	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	after	after	IN	IN	_	20	case	_	_
19	syncytium	syncytium	NN	NN	_	20	compound	_	_
20	formation	formation	NN	NN	_	11	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	dendritic	dendritic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	DCs	dc	NNS	NNS	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	syncytia	syncytium	NNS	NNS	_	3	nsubj	_	_
3	lack	lack	VBP	VBP	_	0	root	_	_
4	activated	activate	VBN	VBN	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	3	dobj	_	_
6	as	as	IN	IN	_	7	mark	_	_
7	determined	determine	VBN	VBN	_	3	advcl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	absence	absence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	mark	_	_
12	staining	stain	VBG	VBG	_	10	acl	_	_
13	for	for	IN	IN	_	17	case	_	_
14	Ki-67	ki-67	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	cycle	cycle	NN	NN	_	17	compound	_	_
17	antigen	antigen	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	expression	expression	NN	NN	_	14	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activity	activity	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Sp1	sp1	NN	NN	_	7	conj	_	_
10	were	be	VBD	VBD	_	14	auxpass	_	_
11	,	,	,	,	_	14	punct	_	_
12	therefore	therefore	RB	RB	_	14	advmod	_	_
13	,	,	,	,	_	14	punct	_	_
14	analyzed	analyze	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	isolated	isolate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	DCs	dc	NNS	NNS	_	18	conj	_	_
21	from	from	IN	IN	_	22	case	_	_
22	humans	human	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	mice	mouse	NNS	NNS	_	22	conj	_	_
25	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	immunolabeling	immunolabeling	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	Western	western	NN	NN	_	8	compound	_	_
7	blot	blot	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	electrophoretic	electrophoretic	JJ	JJ	_	13	amod	_	_
12	mobility	mobility	NN	NN	_	13	compound	_	_
13	shift	shift	NN	NN	_	4	conj	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	supershift	supershift	NN	NN	_	16	compound	_	_
16	assays	assay	NNS	NNS	_	4	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	lack	lack	VBP	VBP	_	0	root	_	_
4	active	active	JJ	JJ	_	6	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	dobj	_	_
7	but	but	CC	CC	_	3	cc	_	_
8	express	express	VBP	VBP	_	3	conj	_	_
9	Sp1	sp1	NN	NN	_	8	dobj	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	expected	expect	VBN	VBN	_	8	advcl	_	_
12	.	.	.	.	_	3	punct	_	_

1	DCs	dc	NNS	NNS	_	2	nsubj	_	_
2	express	express	VBP	VBP	_	0	root	_	_
3	high	high	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	all	all	DT	DT	_	9	dep	_	_
7	known	known	JJ	JJ	_	9	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Rel	rel	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	2	punct	_	_
14	with	with	IN	IN	_	16	mark	_	_
15	activity	activity	NN	NN	_	16	nsubj	_	_
16	residing	reside	VBG	VBG	_	2	advcl	_	_
17	primarily	primarily	RB	RB	_	19	advmod	_	_
18	within	within	IN	IN	_	19	case	_	_
19	RelB	relb	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	p50	p50	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	p65	p65	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	DCs	dc	NNS	NNS	_	4	nsubj	_	_
4	lack	lack	VBP	VBP	_	0	root	_	_
5	Sp1	sp1	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	4	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	explain	explain	VB	VB	_	4	dep	_	_
10	the	the	DT	DT	_	11	det	_	_
11	failure	failure	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HIV-1	hiv-1	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	replicate	replicate	VB	VB	_	11	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	purified	purify	VBN	VBN	_	18	amod	_	_
18	DCs	dc	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Coexpression	coexpression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Sp1	sp1	NN	NN	_	4	conj	_	_
7	occurs	occur	VBZ	VBZ	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	heterologous	heterologous	JJ	JJ	_	12	amod	_	_
11	DC-T-cell	dc-t-cell	NN	NN	_	12	compound	_	_
12	syncytia	syncytia	NN	NN	_	7	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	induced	induce	VBN	VBN	_	12	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	HIV-1	hiv-1	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	HIV-1-induced	hiv-1-induced	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	fusion	fusion	NN	NN	_	6	nsubj	_	_
6	brings	bring	VBZ	VBZ	_	0	root	_	_
7	together	together	RB	RB	_	6	advmod	_	_
8	factors	factor	NNS	NNS	_	6	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	upregulate	upregulate	VBP	VBP	_	8	acl:relcl	_	_
11	virus	virus	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	8	mark	_	_
2	DCs	dc	NNS	NNS	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	memory	memory	NN	NN	_	2	conj	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	4	dep	_	_
7	frequently	frequently	RB	RB	_	8	advmod	_	_
8	traffic	traffic	VBP	VBP	_	18	advcl	_	_
9	together	together	RB	RB	_	8	advmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	situ	situ	FW	FW	_	8	advmod	_	_
12	,	,	,	,	_	18	punct	_	_
13	these	these	DT	DT	_	16	det	_	_
14	unusual	unusual	JJ	JJ	_	16	amod	_	_
15	heterologous	heterologous	JJ	JJ	_	16	amod	_	_
16	syncytia	syncytia	NN	NN	_	18	nsubj	_	_
17	could	could	MD	MD	_	18	aux	_	_
18	develop	develop	VB	VB	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	infected	infected	JJ	JJ	_	21	amod	_	_
21	individuals	individual	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	lead	lead	VB	VB	_	18	conj	_	_
24	to	to	TO	TO	_	27	case	_	_
25	chronic	chronic	JJ	JJ	_	27	amod	_	_
26	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
27	replication	replication	NN	NN	_	23	nmod	_	_
28	without	without	IN	IN	_	31	case	_	_
29	ostensible	ostensible	JJ	JJ	_	31	amod	_	_
30	immune	immune	JJ	JJ	_	31	amod	_	_
31	stimulation	stimulation	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	18	punct	_	_

1	Down-regulation	down-regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	13	compound	_	_
13	D3	d3	NN	NN	_	1	nmod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	17	punct	_	_
15	published	publish	VBN	VBN	_	16	amod	_	_
16	erratum	erratum	NN	NN	_	17	nsubj	_	_
17	appears	appear	VBZ	VBZ	_	1	dep	_	_
18	in	in	IN	IN	_	25	case	_	_
19	Proc	Proc	NNP	NNP	_	25	compound	_	_
20	Natl	Natl	NNP	NNP	_	25	compound	_	_
21	Acad	Acad	NNP	NNP	_	25	compound	_	_
22	Sci	Sci	NNP	NNP	_	25	compound	_	_
23	U	U	NNP	NNP	_	25	compound	_	_
24	S	S	NNP	NNP	_	25	compound	_	_
25	A	A	NNP	NNP	_	17	nmod	_	_
26	1996	1996	CD	CD	_	27	nummod	_	_
27	Jan	Jan	NNP	NNP	_	25	dep	_	_
28	9	9	CD	CD	_	27	nummod	_	_
29	;	;	:	:	_	25	punct	_	_
30	93	93	CD	CD	_	32	nummod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	1	1	CD	CD	_	25	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	:	:	:	:	_	25	punct	_	_
35	524	524	CD	CD	_	25	dep	_	_
36	-RSB-	-rsb-	-RRB-	-RRB-	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	28	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	2	nmod	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	7	punct	_	_
7	1,25(OH)2)D3	1,25(oh)2)d3	NN	NN	_	5	appos	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	steroid	steroid	NN	NN	_	12	compound	_	_
12	hormone	hormone	NN	NN	_	5	appos	_	_
13	with	with	IN	IN	_	15	case	_	_
14	immunomodulating	immunomodulating	NN	NN	_	15	compound	_	_
15	properties	property	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	on	on	IN	IN	_	26	case	_	_
18	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	kappa	kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	proteins	protein	NNS	NNS	_	2	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	examined	examine	VBN	VBN	_	0	root	_	_
29	in	in	IN	IN	_	35	case	_	_
30	in	in	FW	FW	_	35	compound	_	_
31	vitro	vitro	FW	FW	_	35	compound	_	_
32	activated	activate	VBN	VBN	_	35	amod	_	_
33	normal	normal	JJ	JJ	_	35	amod	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
36	by	by	IN	IN	_	39	case	_	_
37	Western	western	NN	NN	_	39	compound	_	_
38	blot	blot	NN	NN	_	39	compound	_	_
39	analysis	analysis	NN	NN	_	28	nmod	_	_
40	.	.	.	.	_	28	punct	_	_

1	Over	over	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	72-hr	72-hr	JJ	JJ	_	4	amod	_	_
4	period	period	NN	NN	_	25	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	activation	activation	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	25	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	25	nsubjpass	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	50-kDa	50-kda	JJ	JJ	_	14	amod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	p50	p50	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	precursor	precursor	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	p105	p105	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	9	punct	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	increased	increase	VBN	VBN	_	0	root	_	_
26	progressively	progressively	RB	RB	_	25	advmod	_	_
27	.	.	.	.	_	25	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	activated	activate	VBN	VBN	_	23	advcl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	23	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	levels	level	NNS	NNS	_	23	nsubjpass	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	mature	mature	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	12	nmod	_	_
17	as	as	RB	RB	_	16	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	precursor	precursor	NN	NN	_	16	conj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	decreased	decrease	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hormone	hormone	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	levels	level	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	p50	p50	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	demonstrable	demonstrable	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	cytosolic	cytosolic	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	nuclear	nuclear	JJ	JJ	_	15	conj	_	_
18	compartments	compartment	NNS	NNS	_	15	dep	_	_
19	;	;	:	:	_	12	punct	_	_
20	it	it	PRP	PRP	_	21	nsubj	_	_
21	required	require	VBD	VBD	_	12	parataxis	_	_
22	between	between	IN	IN	_	26	case	_	_
23	4	4	CD	CD	_	26	nummod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	8	8	CD	CD	_	23	conj	_	_
26	hr	hr	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	was	be	VBD	VBD	_	29	cop	_	_
29	specific	specific	JJ	JJ	_	21	conj	_	_
30	,	,	,	,	_	21	punct	_	_
31	as	as	IN	IN	_	38	mark	_	_
32	25-hydroxyvitamin	25-hydroxyvitamin	NN	NN	_	33	compound	_	_
33	D3	d3	NN	NN	_	38	nsubj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	24,25-dihydroxyvitamin	24,25-dihydroxyvitamin	NN	NN	_	36	compound	_	_
36	D3	d3	NN	NN	_	33	conj	_	_
37	were	be	VBD	VBD	_	38	cop	_	_
38	ineffective	ineffective	JJ	JJ	_	21	advcl	_	_
39	.	.	.	.	_	12	punct	_	_

1	Besides	besides	IN	IN	_	2	case	_	_
2	p50	p50	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	nsubj	_	_
5	decreased	decrease	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	another	another	DT	DT	_	12	det	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	namely	namely	RB	RB	_	15	advmod	_	_
15	c-rel	c-rel	NN	NN	_	12	appos	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	nsubj	_	_
5	decreased	decrease	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	abundance	abundance	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	DNA-protein	dna-protein	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	7	nmod	_	_
13	formed	form	VBN	VBN	_	12	acl	_	_
14	upon	upon	IN	IN	_	15	case	_	_
15	incubation	incubation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	15	nmod	_	_
19	from	from	IN	IN	_	21	case	_	_
20	activated	activate	VBN	VBN	_	21	amod	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
22	with	with	IN	IN	_	29	case	_	_
23	a	a	DT	DT	_	29	det	_	_
24	labeled	label	VBN	VBN	_	29	amod	_	_
25	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
26	B	b	NN	NN	_	29	compound	_	_
27	DNA	dna	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	motif	motif	NN	NN	_	15	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Further	further	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	nsubj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	Jurkat	jurkat	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	transiently	transiently	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBN	VBN	_	13	acl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	construct	construct	NN	NN	_	15	nmod	_	_
19	containing	contain	VBG	VBG	_	18	acl	_	_
20	four	four	CD	CD	_	22	nummod	_	_
21	tandem	tandem	JJ	JJ	_	22	amod	_	_
22	repeats	repeat	NNS	NNS	_	19	dobj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
26	B	b	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	sequence	sequence	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	35	compound	_	_
32	kappa	kappa	NN	NN	_	35	compound	_	_
33	light	light	JJ	JJ	_	35	amod	_	_
34	chain	chain	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	28	nmod	_	_
36	linked	link	VBN	VBN	_	35	acl	_	_
37	to	to	TO	TO	_	42	case	_	_
38	the	the	DT	DT	_	42	det	_	_
39	chloramphenicol	chloramphenicol	NN	NN	_	42	compound	_	_
40	acetyltransferase	acetyltransferase	NN	NN	_	42	compound	_	_
41	reporter	reporter	NN	NN	_	42	compound	_	_
42	gene	gene	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	directly	directly	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	there	there	EX	EX	_	7	expl	_	_
7	is	be	VBZ	VBZ	_	3	ccomp	_	_
8	de	de	FW	FW	_	10	amod	_	_
9	novo	novo	FW	FW	_	8	dep	_	_
10	synthesis	synthesis	NN	NN	_	7	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	during	during	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	7	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	suggest	suggest	VBP	VBP	_	3	conj	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	this	this	DT	DT	_	22	det	_	_
22	process	process	NN	NN	_	25	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	hormonally	hormonally	RB	RB	_	25	advmod	_	_
25	regulated	regulate	VBN	VBN	_	19	ccomp	_	_
26	.	.	.	.	_	3	punct	_	_

1	ETS1	ets1	NN	NN	_	2	nsubj	_	_
2	transactivates	transactivate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	GM-CSF	gm-csf	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	Jurkat	jurkat	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	stimulated	stimulate	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	PMA	pma	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ionomycin	ionomycin	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	helper	helper	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	results	result	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	coordinate	coordinate	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
15	involved	involve	VBN	VBN	_	12	acl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	differentiation	differentiation	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	proliferation	proliferation	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	activation	activation	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	haematopoietic	haematopoietic	JJ	JJ	_	25	amod	_	_
25	system	system	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	one	one	CD	CD	_	10	nummod	_	_
9	such	such	JJ	JJ	_	10	amod	_	_
10	cytokine	cytokine	NN	NN	_	0	root	_	_
11	whose	whose	WP$	WP$	_	13	nmod:poss	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	expression	expression	NN	NN	_	14	nsubj	_	_
14	results	result	VBZ	VBZ	_	10	acl:relcl	_	_
15	partly	partly	RB	RB	_	17	advmod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	increases	increase	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	transcription	transcription	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Cis-acting	cis-acting	JJ	JJ	_	2	amod	_	_
2	elements	element	NNS	NNS	_	14	nsubjpass	_	_
3	with	with	IN	IN	_	6	case	_	_
4	NF	nf	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	AP-1	ap-1	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	ETS-like	ets-like	JJ	JJ	_	11	amod	_	_
11	motifs	motif	NNS	NNS	_	6	conj	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	GM-CSF	gm-csf	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	which	which	WDT	WDT	_	26	nsubj	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	important	important	JJ	JJ	_	14	dep	_	_
27	for	for	IN	IN	_	29	case	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	26	nmod	_	_
30	following	follow	VBG	VBG	_	34	case	_	_
31	PMA	pma	NN	NN	_	34	compound	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	ionomycin	ionomycin	NN	NN	_	31	conj	_	_
34	stimulation	stimulation	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	ETS	ets	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	including	include	VBG	VBG	_	17	case	_	_
17	ETS1	ets1	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	ELF1	elf1	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ability	ability	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	interact	interact	VB	VB	_	5	acl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	site	site	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GM5	gm5	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	located	located	JJ	JJ	_	13	amod	_	_
19	within	within	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	CLE0	cle0	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	-47	-47	CD	CD	_	26	nummod	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	-40	-40	CD	CD	_	22	appos	_	_
27	upstream	upstream	RB	RB	_	26	advmod	_	_
28	of	of	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	GM-CSF	gm-csf	NN	NN	_	33	compound	_	_
31	transcription	transcription	NN	NN	_	33	compound	_	_
32	initiation	initiation	NN	NN	_	33	compound	_	_
33	site	site	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	2	amod	_	_
2	ETS1	ets1	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	ELF1	elf1	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	transactivate	transactivate	VB	VB	_	0	root	_	_
10	GM-CSF	gm-csf	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	9	punct	_	_
12	through	through	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	GM5	gm5	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	in	in	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	PMA	pma	NN	NN	_	22	compound	_	_
20	/ionomycin	/ionomycin	NN	NN	_	22	compound	_	_
21	dependent	dependent	JJ	JJ	_	22	amod	_	_
22	manner	manner	NN	NN	_	9	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	unidentified	unidentified	JJ	JJ	_	4	amod	_	_
3	ETS-like	ets-like	JJ	JJ	_	4	amod	_	_
4	factors	factor	NNS	NNS	_	11	nsubj	_	_
5	present	present	JJ	JJ	_	4	amod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	capable	capable	JJ	JJ	_	0	root	_	_
12	of	of	IN	IN	_	13	mark	_	_
13	binding	bind	VBG	VBG	_	11	advcl	_	_
14	GM5	gm5	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	11	punct	_	_

1	Mutation	mutation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	core	core	NN	NN	_	1	nmod	_	_
5	ETS	ets	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	4	dep	_	_
8	from	from	IN	IN	_	11	case	_	_
9	-GGAA-	-ggaa-	NN	NN	_	11	compound	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	-GGAT-	-ggat-	NN	NN	_	4	nmod	_	_
12	prevents	prevent	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	binding	binding	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	ETS-like	ets-like	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	exception	exception	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	ETS1	ets1	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GM-CSF	gm-csf	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	modified	modify	VBN	VBN	_	3	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	way	way	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	ETS1	ets1	NN	NN	_	12	nmod:npmod	_	_
12	specific	specific	JJ	JJ	_	5	xcomp	_	_
13	,	,	,	,	_	3	punct	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	fully	fully	RB	RB	_	16	advmod	_	_
16	responsive	responsive	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	20	case	_	_
18	PMA	pma	NN	NN	_	20	compound	_	_
19	/ionomycin	/ionomycin	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	addition	addition	NN	NN	_	16	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	ETS1	ets1	NN	NN	_	26	compound	_	_
26	transactivation	transactivation	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	PMA	pma	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	ionomycin	ionomycin	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	16	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	ETS1	ets1	NN	NN	_	9	nsubjpass	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	4	ccomp	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	mediating	mediate	VBG	VBG	_	9	advcl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	increased	increase	VBN	VBN	_	15	amod	_	_
14	GM-CSF	gm-csf	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	11	dobj	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Salicylates	salicylate	NNS	NNS	_	2	nsubj	_	_
2	inhibit	inhibit	VBP	VBP	_	0	root	_	_
3	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	5	amod	_	_
4	transcriptional	transcriptional	JJ	JJ	_	3	dep	_	_
5	activation	activation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	tissue	tissue	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Binding	binding	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	plasma	plasma	NN	NN	_	5	compound	_	_
4	Factor	factor	NN	NN	_	5	compound	_	_
5	VII/VIIa	vii/viia	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	tissue	tissue	NN	NN	_	13	compound	_	_
9	factor	factor	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	TF	tf	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	receptor	receptor	NN	NN	_	1	nmod	_	_
14	initiates	initiate	VBZ	VBZ	_	0	root	_	_
15	the	the	DT	DT	_	18	det	_	_
16	coagulation	coagulation	NN	NN	_	17	compound	_	_
17	protease	protease	NN	NN	_	18	compound	_	_
18	cascades	cascade	NNS	NNS	_	14	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	TF	tf	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	7	nsubjpass	_	_
3	by	by	IN	IN	_	5	case	_	_
4	circulating	circulate	VBG	VBG	_	5	amod	_	_
5	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	thrombotic	thrombotic	JJ	JJ	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	inflammatory	inflammatory	JJ	JJ	_	9	conj	_	_
12	complications	complication	NNS	NNS	_	9	dep	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	variety	variety	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	diseases	disease	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	TF	tf	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	exposed	expose	VBN	VBN	_	10	acl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	bacterial	bacterial	JJ	JJ	_	14	amod	_	_
14	lipopolysaccharide	lipopolysaccharide	NN	NN	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	LPS	lps	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	mediated	mediate	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	21	case	_	_
21	binding	binding	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	c-Rel	c-rel	NN	NN	_	25	compound	_	_
24	/p65	/p65	NN	NN	_	25	compound	_	_
25	heterodimers	heterodimer	NNS	NNS	_	21	nmod	_	_
26	to	to	TO	TO	_	30	case	_	_
27	a	a	DT	DT	_	30	det	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	21	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	TF	tf	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	19	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	a	a	DT	DT	_	7	det	_	_
7	family	family	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	anti-inflammatory	anti-inflammatory	JJ	JJ	_	10	amod	_	_
10	agents	agent	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	known	know	VBN	VBN	_	7	acl	_	_
13	as	as	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	salicylates	salicylate	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	inhibited	inhibit	VBD	VBD	_	4	ccomp	_	_
18	LPS	lps	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	TF	tf	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	TF	tf	NN	NN	_	25	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	19	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	monocytic	monocytic	JJ	JJ	_	33	amod	_	_
32	THP-1	thp-1	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	conj	_	_
34	at	at	IN	IN	_	37	case	_	_
35	clinically	clinically	RB	RB	_	36	advmod	_	_
36	relevant	relevant	JJ	JJ	_	37	amod	_	_
37	doses	dose	NNS	NNS	_	17	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	sodium	sodium	NN	NN	_	4	compound	_	_
4	salicylate	salicylate	NN	NN	_	5	nsubj	_	_
5	blocked	block	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	9	amod	_	_
8	proteolytic	proteolytic	JJ	JJ	_	7	dep	_	_
9	degradation	degradation	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	I	i	NN	NN	_	14	compound	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	prevented	prevent	VBD	VBD	_	5	dep	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	c-Rel	c-rel	NN	NN	_	24	compound	_	_
23	/p65	/p65	NN	NN	_	24	compound	_	_
24	heterodimers	heterodimer	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	two	two	CD	CD	_	8	nummod	_	_
5	other	other	JJ	JJ	_	8	amod	_	_
6	nonsteroidal	nonsteroidal	JJ	JJ	_	8	amod	_	_
7	anti-inflammatory	anti-inflammatory	JJ	JJ	_	6	dep	_	_
8	drugs	drug	NNS	NNS	_	16	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	ibuprofen	ibuprofen	NN	NN	_	8	appos	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	indomethacin	indomethacin	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	did	do	VBD	VBD	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	inhibit	inhibit	VB	VB	_	0	root	_	_
17	LPS	lps	NN	NN	_	18	compound	_	_
18	induction	induction	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	TF	tf	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	salicylates	salicylate	NNS	NNS	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
7	LPS	lps	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	TF	tf	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	preventing	prevent	VBG	VBG	_	6	advcl	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	translocation	translocation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	c-Rel	c-rel	NN	NN	_	23	compound	_	_
22	/p65	/p65	NN	NN	_	23	compound	_	_
23	heterodimers	heterodimer	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	benefits	benefit	NNS	NNS	_	21	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	salicylates	salicylate	NNS	NNS	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	treatment	treatment	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	diseases	disease	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	including	include	VBG	VBG	_	14	case	_	_
14	atherosclerosis	atherosclerosis	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	rheumatoid	rheumatoid	NN	NN	_	17	compound	_	_
17	arthritis	arthritis	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	3	punct	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	related	related	JJ	JJ	_	0	root	_	_
22	to	to	TO	TO	_	24	case	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	ability	ability	NN	NN	_	21	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	reduce	reduce	VB	VB	_	24	acl	_	_
27	monocyte	monocyte	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	21	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	nucleoside	nucleoside	NN	NN	_	6	compound	_	_
5	diphosphate	diphosphate	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	skin	skin	NN	NN	_	10	compound	_	_
10	cancers	cancer	NNS	NNS	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	an	a	DT	DT	_	14	det	_	_
13	immunohistochemical	immunohistochemical	JJ	JJ	_	14	amod	_	_
14	study	study	NN	NN	_	1	dep	_	_
15	.	.	.	.	_	1	punct	_	_

1	Expression	expression	NN	NN	_	26	nsubjpass	_	_
2	of	of	IN	IN	_	8	case	_	_
3	nucleoside	nucleoside	NN	NN	_	8	compound	_	_
4	diphosphate	diphosphate	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	NDP	ndp	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	kinase	kinase	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	homologous	homologous	JJ	JJ	_	8	acl:relcl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	nm23	nm23	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	product	product	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	variety	variety	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	species	species	NNS	NNS	_	20	nmod	_	_
23	,	,	,	,	_	1	punct	_	_
24	has	have	VBZ	VBZ	_	26	aux	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	found	find	VBN	VBN	_	0	root	_	_
27	to	to	TO	TO	_	30	mark	_	_
28	be	be	VB	VB	_	30	auxpass	_	_
29	inversely	inversely	RB	RB	_	30	advmod	_	_
30	associated	associate	VBN	VBN	_	26	xcomp	_	_
31	with	with	IN	IN	_	33	case	_	_
32	metastatic	metastatic	JJ	JJ	_	33	amod	_	_
33	potential	potential	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	26	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	relationship	relationship	NN	NN	_	5	nsubj	_	_
5	remains	remain	VBZ	VBZ	_	0	root	_	_
6	controversial	controversial	JJ	JJ	_	5	xcomp	_	_
7	according	accord	VBG	VBG	_	12	case	_	_
8	to	to	TO	TO	_	7	mwe	_	_
9	the	the	DT	DT	_	12	dep	_	_
10	tumor	tumor	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	types	type	NNS	NNS	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	experimental	experimental	JJ	JJ	_	15	amod	_	_
15	system	system	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	6	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	conflicting	conflict	VBG	VBG	_	19	amod	_	_
19	results	result	NNS	NNS	_	6	nmod	_	_
20	from	from	IN	IN	_	23	case	_	_
21	different	different	JJ	JJ	_	23	amod	_	_
22	research	research	NN	NN	_	23	compound	_	_
23	groups	group	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	22	advcl	_	_
5	whether	whether	IN	IN	_	9	mark	_	_
6	NDP	ndp	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	9	nsubj	_	_
9	serves	serve	VBZ	VBZ	_	4	ccomp	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	marker	marker	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	metastatic	metastatic	JJ	JJ	_	15	amod	_	_
15	potential	potential	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	skin	skin	NN	NN	_	19	compound	_	_
19	cancer	cancer	NN	NN	_	12	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	we	we	PRP	PRP	_	22	nsubj	_	_
22	assessed	assess	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	levels	level	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	NDP	ndp	NN	NN	_	27	compound	_	_
27	kinase	kinase	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	9	9	CD	CD	_	31	nummod	_	_
31	keratoacanthomas	keratoacanthoma	NNS	NNS	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	KAs	ka	NNS	NNS	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	31	punct	_	_
36	26	26	CD	CD	_	39	nummod	_	_
37	squamous	squamous	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	carcinomas	carcinoma	NNS	NNS	_	31	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	SCCs	scc	NNS	NNS	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	31	punct	_	_
44	and	and	CC	CC	_	31	cc	_	_
45	25	25	CD	CD	_	48	nummod	_	_
46	basal	basal	JJ	JJ	_	48	amod	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	carcinomas	carcinoma	NNS	NNS	_	31	conj	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	BCCs	bcc	NNS	NNS	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	using	use	VBG	VBG	_	22	xcomp	_	_
53	immunohistochemistry	immunohistochemistry	NN	NN	_	52	dobj	_	_
54	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NDP	ndp	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	intense	intense	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	KA	ka	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	SCC	scc	NN	NN	_	9	conj	_	_
12	compared	compare	VBN	VBN	_	14	case	_	_
13	with	with	IN	IN	_	14	case	_	_
14	BCC	bcc	NN	NN	_	7	advcl	_	_
15	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	difference	difference	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	NDP	ndp	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	between	between	IN	IN	_	10	case	_	_
10	KA	ka	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	SCC	scc	NN	NN	_	10	conj	_	_
13	was	be	VBD	VBD	_	16	cop	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	statistically	statistically	RB	RB	_	16	advmod	_	_
16	significant	significant	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	And	and	CC	CC	_	3	cc	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	was	be	VBD	VBD	_	0	root	_	_
4	no	no	DT	DT	_	7	neg	_	_
5	statistically	statistically	RB	RB	_	6	advmod	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	difference	difference	NN	NN	_	3	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	NDP	ndp	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	SCC	scc	NN	NN	_	7	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	metastasis	metastasis	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	SCC	scc	NN	NN	_	13	conj	_	_
18	without	without	IN	IN	_	19	case	_	_
19	metastasis	metastasis	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	contradict	contradict	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	concerning	concern	VBG	VBG	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	possible	possible	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	nm23	nm23	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	9	nmod	_	_
13	as	as	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	metastatic	metastatic	JJ	JJ	_	17	amod	_	_
16	suppressor	suppressor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	9	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	skin	skin	NN	NN	_	21	compound	_	_
21	cancer	cancer	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	overexpression	overexpression	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	various	various	JJ	JJ	_	9	amod	_	_
7	tumor	tumor	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	types	type	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	biological	biological	JJ	JJ	_	13	amod	_	_
13	significance	significance	NN	NN	_	2	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	cutaneous	cutaneous	JJ	JJ	_	16	amod	_	_
16	carcinogenesis	carcinogenesis	NN	NN	_	13	nmod	_	_
17	remain	remain	VB	VB	_	0	root	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	determined	determine	VBN	VBN	_	17	xcomp	_	_
21	.	.	.	.	_	17	punct	_	_

1	Synergy	synergy	NN	NN	_	7	nsubj	_	_
2	between	between	IN	IN	_	5	case	_	_
3	signal	signal	NN	NN	_	5	compound	_	_
4	transduction	transduction	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	obligatory	obligatory	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	expression	expression	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-fos	c-fos	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	B	b	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	13	conj	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	dep	_	_
18	:	:	:	:	_	7	punct	_	_
19	implication	implication	NN	NN	_	7	dep	_	_
20	for	for	IN	IN	_	22	case	_	_
21	c-fos	c-fos	NN	NN	_	22	compound	_	_
22	control	control	NN	NN	_	19	nmod	_	_
23	via	via	IN	IN	_	25	case	_	_
24	surface	surface	NN	NN	_	25	compound	_	_
25	immunoglobulin	immunoglobulin	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	antigen	antigen	NN	NN	_	30	compound	_	_
30	receptors	receptor	NNS	NNS	_	25	conj	_	_
31	.	.	.	.	_	7	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	protooncogene	protooncogene	NN	NN	_	5	compound	_	_
5	c-fos	c-fos	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	controlled	control	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	three	three	CD	CD	_	12	nummod	_	_
10	main	main	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	pathways	pathway	NNS	NNS	_	7	nmod	_	_
13	involving	involve	VBG	VBG	_	12	acl	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	cAMP	camp	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	calcium	calcium	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Kinase	kinase	NN	NN	_	2	compound	_	_
2	C	c	NN	NN	_	3	nsubj	_	_
3	mediates	mediate	VBZ	VBZ	_	0	root	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	via	via	IN	IN	_	7	case	_	_
7	phosphorylation	phosphorylation	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	serum	serum	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	SRF	srf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	interacts	interact	VBZ	VBZ	_	11	acl:relcl	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	serum	serum	NN	NN	_	21	compound	_	_
20	response	response	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	SRE	sre	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	;	;	:	:	_	3	punct	_	_
26	cAMP	camp	NN	NN	_	29	nsubj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	calcium	calcium	NN	NN	_	26	conj	_	_
29	mediate	mediate	VBP	VBP	_	3	parataxis	_	_
30	their	they	PRP$	PRP$	_	31	nmod:poss	_	_
31	effects	effect	NNS	NNS	_	29	dobj	_	_
32	via	via	IN	IN	_	33	case	_	_
33	phosphorylation	phosphorylation	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	CREB	creb	NN	NN	_	33	nmod	_	_
36	(	(	-LRB-	-LRB-	_	41	punct	_	_
37	cAMP	camp	NN	NN	_	41	compound	_	_
38	regulatory	regulatory	JJ	JJ	_	41	amod	_	_
39	element	element	NN	NN	_	41	compound	_	_
40	binding	binding	NN	NN	_	41	compound	_	_
41	protein	protein	NN	NN	_	35	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	presumably	presumably	RB	RB	_	45	advmod	_	_
44	by	by	IN	IN	_	45	case	_	_
45	activation	activation	NN	NN	_	33	nmod	_	_
46	of	of	IN	IN	_	50	case	_	_
47	a	a	DT	DT	_	50	det	_	_
48	protein	protein	NN	NN	_	50	compound	_	_
49	kinase	kinase	NN	NN	_	50	compound	_	_
50	A	a	NN	NN	_	45	nmod	_	_
51	or	or	CC	CC	_	50	cc	_	_
52	calmodulin-regulated	calmodulin-regulated	JJ	JJ	_	53	amod	_	_
53	kinase	kinase	NN	NN	_	50	conj	_	_
54	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	function	function	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	elements	element	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	Burkitt	burkitt	NN	NN	_	13	nmod:poss	_	_
11	's	's	POS	POS	_	13	case	_	_
12	lymphoma	lymphoma	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Ramos	ramos	NN	NN	_	13	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Daudi	daudi	NN	NN	_	15	conj	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	as	as	RB	RB	_	13	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	a	a	DT	DT	_	26	det	_	_
23	T	t	NN	NN	_	26	compound	_	_
24	lymphocytic	lymphocytic	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	13	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	Jurkat	jurkat	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	any	any	DT	DT	_	8	det	_	_
8	one	one	CD	CD	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	pathways	pathway	NNS	NNS	_	8	nmod	_	_
12	alone	alone	RB	RB	_	8	advmod	_	_
13	has	have	VBZ	VBZ	_	3	ccomp	_	_
14	little	little	JJ	JJ	_	13	dobj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	no	no	DT	DT	_	14	conj	_	_
17	effect	effect	NN	NN	_	14	dep	_	_
18	on	on	IN	IN	_	20	case	_	_
19	c-fos	c-fos	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	C	c	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	25	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	PMA	pma	NN	NN	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	combined	combine	VBN	VBN	_	5	acl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	either	either	CC	CC	_	13	cc:preconj	_	_
13	cAMP	camp	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	forskolin	forskolin	NN	NN	_	13	dep	_	_
16	plus	plus	CC	CC	_	15	cc	_	_
17	MIX	mix	NN	NN	_	15	conj	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	or	or	CC	CC	_	13	cc	_	_
20	calcium	calcium	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	13	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	ionophore	ionophore	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	leads	lead	VBZ	VBZ	_	0	root	_	_
26	to	to	TO	TO	_	30	case	_	_
27	greatly	greatly	RB	RB	_	28	advmod	_	_
28	enhanced	enhance	VBN	VBN	_	30	amod	_	_
29	c-fos	c-fos	NN	NN	_	30	compound	_	_
30	induction	induction	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	25	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	cAMP	camp	NN	NN	_	10	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	calcium	calcium	NN	NN	_	7	nmod	_	_
10	shows	show	VBZ	VBZ	_	0	root	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	synergy	synergy	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	c-fos	c-fos	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Okadaic	okadaic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	augments	augment	VBZ	VBZ	_	0	root	_	_
4	PMA-	pma-	NN	NN	_	9	amod	_	_
5	as	as	RB	RB	_	4	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	calcium-mediated	calcium-mediated	JJ	JJ	_	4	conj	_	_
9	activation	activation	NN	NN	_	3	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-fos	c-fos	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	has	have	VBZ	VBZ	_	3	conj	_	_
15	little	little	JJ	JJ	_	14	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	no	no	DT	DT	_	15	conj	_	_
18	effect	effect	NN	NN	_	15	dep	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	combined	combine	VBN	VBN	_	14	advcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	cAMP	camp	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	main	main	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	21	nsubj	_	_
4	between	between	IN	IN	_	5	case	_	_
5	Ramos	ramos	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	Jurkat	jurkat	NN	NN	_	5	conj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	regulation	regulation	NN	NN	_	3	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	c-fos	c-fos	NN	NN	_	18	nmod	_	_
21	is	be	VBZ	VBZ	_	0	root	_	_
22	that	that	IN	IN	_	28	mark	_	_
23	cAMP	camp	NN	NN	_	28	nsubj	_	_
24	plus	plus	CC	CC	_	23	cc	_	_
25	calcium	calcium	NN	NN	_	23	conj	_	_
26	is	be	VBZ	VBZ	_	28	cop	_	_
27	strongly	strongly	RB	RB	_	28	advmod	_	_
28	synergistic	synergistic	JJ	JJ	_	21	ccomp	_	_
29	in	in	IN	IN	_	30	case	_	_
30	Jurkat	jurkat	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	is	be	VBZ	VBZ	_	34	cop	_	_
33	without	without	IN	IN	_	34	case	_	_
34	effect	effect	NN	NN	_	28	conj	_	_
35	in	in	IN	IN	_	36	case	_	_
36	Ramos	ramos	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	21	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	AP-1	ap-1	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	using	use	VBG	VBG	_	1	acl	_	_
6	gel	gel	NN	NN	_	9	compound	_	_
7	mobility	mobility	NN	NN	_	9	compound	_	_
8	shift	shift	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	5	dobj	_	_
10	confirms	confirm	VBZ	VBZ	_	0	root	_	_
11	that	that	IN	IN	_	21	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	requirements	requirement	NNS	NNS	_	21	nsubjpass	_	_
14	for	for	IN	IN	_	15	case	_	_
15	synergy	synergy	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	c-fos	c-fos	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	15	nmod	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	paralleled	parallel	VBN	VBN	_	10	ccomp	_	_
22	by	by	IN	IN	_	23	case	_	_
23	requirements	requirement	NNS	NNS	_	21	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	synergy	synergy	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	induction	induction	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	AP-1	ap-1	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	Signaling	signaling	NN	NN	_	9	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	due	due	JJ	JJ	_	1	amod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	anti-Ig	anti-ig	JJ	JJ	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	5	nmod	_	_
9	involves	involve	VBZ	VBZ	_	0	root	_	_
10	both	both	CC	CC	_	13	cc:preconj	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	C	c	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	release	release	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	calcium	calcium	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	results	result	VBZ	VBZ	_	9	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	c-fos	c-fos	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	induction	induction	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	synergy	synergy	NN	NN	_	14	nsubjpass	_	_
6	between	between	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	C	c	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	calcium	calcium	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	needed	need	VBN	VBN	_	3	ccomp	_	_
15	for	for	IN	IN	_	18	case	_	_
16	efficient	efficient	JJ	JJ	_	18	amod	_	_
17	c-fos	c-fos	NN	NN	_	18	compound	_	_
18	induction	induction	NN	NN	_	14	nmod	_	_
19	since	since	IN	IN	_	25	mark	_	_
20	neither	neither	DT	DT	_	25	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	two	two	CD	CD	_	20	nmod	_	_
24	alone	alone	RB	RB	_	20	advmod	_	_
25	induces	induce	VBZ	VBZ	_	14	advcl	_	_
26	c-fos	c-fos	NN	NN	_	25	dobj	_	_
27	well	well	RB	RB	_	25	advmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	That	that	IN	IN	_	7	mark	_	_
2	synergy	synergy	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	pathways	pathway	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	relevant	relevant	JJ	JJ	_	15	csubjpass	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	anti-Ig	anti-ig	JJ	JJ	_	11	compound	_	_
11	induction	induction	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	c-fos	c-fos	NN	NN	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	supported	support	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	fact	fact	NN	NN	_	15	nmod	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	cAMP-inducing	camp-inducing	JJ	JJ	_	21	amod	_	_
21	agents	agent	NNS	NNS	_	26	nsubj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	okadaic	okadaic	JJ	JJ	_	24	amod	_	_
24	acid	acid	NN	NN	_	21	conj	_	_
25	further	further	RB	RB	_	26	advmod	_	_
26	enhance	enhance	VBP	VBP	_	18	ccomp	_	_
27	anti-Ig	anti-ig	JJ	JJ	_	28	compound	_	_
28	induction	induction	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	c-fos	c-fos	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
6	patterns	pattern	NNS	NNS	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	synergy	synergy	NN	NN	_	6	nmod	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	an	a	DT	DT	_	12	det	_	_
11	essential	essential	JJ	JJ	_	12	amod	_	_
12	feature	feature	NN	NN	_	3	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	c-fos	c-fos	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	may	may	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	relevant	relevant	JJ	JJ	_	12	conj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	c-fos	c-fos	NN	NN	_	22	compound	_	_
22	control	control	NN	NN	_	19	nmod	_	_
23	through	through	IN	IN	_	24	case	_	_
24	B	b	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	T	t	NN	NN	_	24	conj	_	_
27	cell	cell	NN	NN	_	29	compound	_	_
28	antigen	antigen	NN	NN	_	29	compound	_	_
29	receptors	receptor	NNS	NNS	_	24	dep	_	_
30	.	.	.	.	_	3	punct	_	_

1	Hemoglobin	hemoglobin	NN	NN	_	2	compound	_	_
2	switching	switching	NN	NN	_	6	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	humans	human	NNS	NNS	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	changes	change	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	ratio	ratio	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	GATA-1	gata-1	NN	NN	_	15	appos	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	SP1	sp1	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Understanding	understand	VBG	VBG	_	12	csubj	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	developmental	developmental	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	hemoglobin	hemoglobin	NN	NN	_	11	compound	_	_
11	switching	switching	NN	NN	_	8	nmod	_	_
12	has	have	VBZ	VBZ	_	1	dep	_	_
13	scientific	scientific	JJ	JJ	_	12	dobj	_	_
14	as	as	RB	RB	_	13	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	clinical	clinical	JJ	JJ	_	13	conj	_	_
18	relevance	relevance	NN	NN	_	13	dep	_	_
19	because	because	IN	IN	_	22	case	_	_
20	of	of	IN	IN	_	19	mwe	_	_
21	the	the	DT	DT	_	22	det	_	_
22	influence	influence	NN	NN	_	12	nmod	_	_
23	of	of	IN	IN	_	29	case	_	_
24	fetal	fetal	JJ	JJ	_	25	amod	_	_
25	hemoglobin	hemoglobin	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	HbF	hbf	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	production	production	NN	NN	_	22	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	adulthood	adulthood	NN	NN	_	29	nmod	_	_
32	on	on	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	clinical	clinical	JJ	JJ	_	35	amod	_	_
35	manifestation	manifestation	NN	NN	_	22	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	thalassemia	thalassemia	NN	NN	_	35	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	sickle	sickle	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	anemia	anemia	NN	NN	_	37	conj	_	_
42	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	developmental	developmental	JJ	JJ	_	9	amod	_	_
9	patterns	pattern	NNS	NNS	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	13	case	_	_
11	globin	globin	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	recapitulated	recapitulate	VBN	VBN	_	4	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	experimental	experimental	JJ	JJ	_	19	amod	_	_
19	system	system	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	primary	primary	JJ	JJ	_	22	amod	_	_
22	cultures	culture	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	support	support	VBP	VBP	_	22	acl:relcl	_	_
25	differentiation	differentiation	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	erythroid	erythroid	JJ	JJ	_	28	amod	_	_
28	progenitors	progenitor	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	activities	activity	NNS	NNS	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activators	activator	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	GATA-1	gata-1	NN	NN	_	10	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	SP1	sp1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	6	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	associated	associate	VBN	VBN	_	3	ccomp	_	_
18	with	with	IN	IN	_	22	case	_	_
19	normal	normal	JJ	JJ	_	22	amod	_	_
20	adult	adult	JJ	JJ	_	22	amod	_	_
21	erythroid	erythroid	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	In	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	present	present	JJ	JJ	_	8	amod	_	_
8	work	work	NN	NN	_	12	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	studied	study	VBN	VBN	_	1	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activities	activity	NNS	NNS	_	12	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	GATA-1	gata-1	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	SP1	sp1	NN	NN	_	17	conj	_	_
20	during	during	IN	IN	_	21	case	_	_
21	differentiation	differentiation	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	cultured	culture	VBN	VBN	_	25	amod	_	_
24	erythroid	erythroid	JJ	JJ	_	25	amod	_	_
25	progenitors	progenitor	NNS	NNS	_	21	nmod	_	_
26	derived	derive	VBN	VBN	_	25	acl	_	_
27	from	from	IN	IN	_	29	case	_	_
28	cord	cord	NN	NN	_	29	compound	_	_
29	blood	blood	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	from	from	IN	IN	_	33	case	_	_
32	fetal	fetal	JJ	JJ	_	33	amod	_	_
33	livers	liver	NNS	NNS	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	as	as	RB	RB	_	29	cc	_	_
36	well	well	RB	RB	_	35	mwe	_	_
37	as	as	IN	IN	_	35	mwe	_	_
38	from	from	IN	IN	_	41	case	_	_
39	beta	beta	NN	NN	_	41	compound	_	_
40	zero-thalassemia	zero-thalassemia	JJ	JJ	_	41	amod	_	_
41	patients	patient	NNS	NNS	_	29	conj	_	_
42	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	1	dep	_	_
6	high	high	JJ	JJ	_	9	amod	_	_
7	GATA-1	gata-1	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	very	very	RB	RB	_	12	advmod	_	_
12	low	low	JJ	JJ	_	14	amod	_	_
13	SP1	sp1	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	9	conj	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	fetal	fetal	JJ	JJ	_	19	amod	_	_
18	liver	liver	NN	NN	_	19	compound	_	_
19	cultures	culture	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	in	in	IN	IN	_	5	case	_	_
5	contrast	contrast	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	cultures	culture	NNS	NNS	_	5	nmod	_	_
8	derived	derive	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	13	case	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	adult	adult	JJ	JJ	_	13	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
13	blood	blood	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	23	nmod	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	GATA-1	gata-1	NN	NN	_	23	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	SP1	sp1	NN	NN	_	18	conj	_	_
21	activities	activity	NNS	NNS	_	18	dep	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	high	high	JJ	JJ	_	7	acl:relcl	_	_
24	.	.	.	.	_	5	punct	_	_

1	Cord	cord	NN	NN	_	3	compound	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	cultures	culture	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	additive	additive	JJ	JJ	_	7	amod	_	_
7	combination	combination	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	``	``	``	``	_	10	punct	_	_
10	adult	adult	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	``	``	``	``	_	13	punct	_	_
13	fetal	fetal	JJ	JJ	_	10	conj	_	_
14	patterns	pattern	NNS	NNS	_	10	dep	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	progenitors	progenitor	NNS	NNS	_	13	nsubj	_	_
3	derived	derive	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	beta	beta	NN	NN	_	8	compound	_	_
7	zero-thalassemia	zero-thalassemia	JJ	JJ	_	8	amod	_	_
8	patient	patient	NN	NN	_	3	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	high	high	JJ	JJ	_	12	amod	_	_
11	HbF	hbf	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	nmod	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	``	``	``	``	_	16	punct	_	_
15	fetal	fetal	JJ	JJ	_	16	amod	_	_
16	pattern	pattern	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	13	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	21	nmod	_	_
5	,	,	,	,	_	21	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cultures	culture	NNS	NNS	_	21	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	2	2	CD	CD	_	12	nummod	_	_
10	beta	beta	NN	NN	_	12	compound	_	_
11	zero-thalassemia	zero-thalassemia	JJ	JJ	_	12	amod	_	_
12	patients	patient	NNS	NNS	_	7	nmod	_	_
13	without	without	IN	IN	_	15	case	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	HbF	hbf	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	``	``	``	``	_	19	punct	_	_
18	adult	adult	JJ	JJ	_	19	amod	_	_
19	pattern	pattern	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	observed	observe	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	work	work	NN	NN	_	9	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	show	show	VBP	VBP	_	1	dep	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	fetal	fetal	JJ	JJ	_	18	nsubj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	adult	adult	JJ	JJ	_	12	conj	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	progenitors	progenitor	NNS	NNS	_	12	dep	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	distinct	distinct	JJ	JJ	_	9	ccomp	_	_
19	in	in	IN	IN	_	22	case	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	18	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	that	that	IN	IN	_	33	mark	_	_
26	the	the	DT	DT	_	27	det	_	_
27	commitment	commitment	NN	NN	_	33	nsubj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	fetal	fetal	JJ	JJ	_	27	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	adult	adult	JJ	JJ	_	29	conj	_	_
32	program	program	NN	NN	_	29	dep	_	_
33	occurs	occur	VBZ	VBZ	_	18	conj	_	_
34	at	at	IN	IN	_	39	case	_	_
35	a	a	DT	DT	_	39	det	_	_
36	very	very	RB	RB	_	37	advmod	_	_
37	early	early	JJ	JJ	_	39	amod	_	_
38	differentiation	differentiation	NN	NN	_	39	compound	_	_
39	stage	stage	NN	NN	_	33	nmod	_	_
40	.	.	.	.	_	1	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	under	under	IN	IN	_	8	case	_	_
7	anemic	anemic	JJ	JJ	_	8	amod	_	_
8	stress	stress	NN	NN	_	15	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	recruitment	recruitment	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	fetal	fetal	JJ	JJ	_	13	amod	_	_
13	progenitors	progenitor	NNS	NNS	_	10	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	occur	occur	VB	VB	_	4	ccomp	_	_
16	in	in	IN	IN	_	17	case	_	_
17	adulthood	adulthood	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	CIITA	ciita	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	MHC	mhc	NN	NN	_	9	compound	_	_
7	class	class	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	genes	gene	NNS	NNS	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	mouse	mouse	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	6	nsubj	_	_
2	has	have	VBZ	VBZ	_	6	aux	_	_
3	long	long	RB	RB	_	6	advmod	_	_
4	been	be	VBN	VBN	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	puzzle	puzzle	NN	NN	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	MHC	mhc	NN	NN	_	11	compound	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	molecules	molecule	NNS	NNS	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	6	ccomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	after	after	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	17	nmod	_	_
20	but	but	CC	CC	_	17	cc	_	_
21	not	not	RB	RB	_	25	neg	_	_
22	in	in	IN	IN	_	25	case	_	_
23	mouse	mouse	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	17	conj	_	_
26	;	;	:	:	_	6	punct	_	_
27	this	this	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	30	nsubjpass	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	believed	believe	VBN	VBN	_	6	parataxis	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	play	play	VB	VB	_	30	xcomp	_	_
33	a	a	DT	DT	_	34	det	_	_
34	role	role	NN	NN	_	32	dobj	_	_
35	in	in	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	cell	cell	NN	NN	_	40	compound	_	_
38	mediated	mediated	JJ	JJ	_	40	amod	_	_
39	immune	immune	JJ	JJ	_	40	amod	_	_
40	response	response	NN	NN	_	32	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Recently	recently	RB	RB	_	12	advmod	_	_
2	the	the	DT	DT	_	6	det	_	_
3	MHC	mhc	NN	NN	_	6	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	transactivator	transactivator	NN	NN	_	12	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CIITA	ciita	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	reported	report	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	18	mark	_	_
14	be	be	VB	VB	_	18	cop	_	_
15	a	a	DT	DT	_	18	det	_	_
16	major	major	JJ	JJ	_	18	amod	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	12	xcomp	_	_
19	for	for	IN	IN	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	constitutive	constitutive	JJ	JJ	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IFN	ifn	NN	NN	_	25	nmod:npmod	_	_
25	inducible	inducible	JJ	JJ	_	22	conj	_	_
26	expression	expression	NN	NN	_	22	dep	_	_
27	of	of	IN	IN	_	31	case	_	_
28	MHC	mhc	NN	NN	_	31	compound	_	_
29	class	class	NN	NN	_	31	compound	_	_
30	II	ii	CD	CD	_	31	nummod	_	_
31	genes	gene	NNS	NNS	_	22	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	12	nsubj	_	_
8	expressing	express	VBG	VBG	_	7	acl	_	_
9	MHC	mhc	NN	NN	_	10	compound	_	_
10	class	class	NN	NN	_	8	dobj	_	_
11	II	ii	CD	CD	_	10	nummod	_	_
12	have	have	VBP	VBP	_	3	ccomp	_	_
13	CIITA	ciita	NN	NN	_	14	compound	_	_
14	transcripts	transcript	NNS	NNS	_	12	dobj	_	_
15	while	while	IN	IN	_	26	mark	_	_
16	MHC	mhc	NN	NN	_	17	compound	_	_
17	class	class	NN	NN	_	26	nsubj	_	_
18	II-negative	ii-negative	JJ	JJ	_	17	amod	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	dep	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	mouse	mouse	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	17	conj	_	_
26	do	do	VBP	VBP	_	12	advcl	_	_
27	not	not	RB	RB	_	26	neg	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	MHC	mhc	NN	NN	_	7	compound	_	_
5	class	class	NN	NN	_	7	compound	_	_
6	II	ii	CD	CD	_	7	nummod	_	_
7	genes	gene	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	mouse	mouse	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	reconstituted	reconstitute	VBN	VBN	_	0	root	_	_
15	upon	upon	IN	IN	_	16	case	_	_
16	transfection	transfection	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	CIITA	ciita	NN	NN	_	21	compound	_	_
21	cDNA	cdna	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CIITA	ciita	NN	NN	_	6	nmod	_	_
9	explains	explain	VBZ	VBZ	_	3	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	lack	lack	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	expression	expression	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	MHC	mhc	NN	NN	_	18	compound	_	_
18	class	class	NN	NN	_	11	nmod	_	_
19	II	ii	CD	CD	_	18	nummod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	human	human	JJ	JJ	_	11	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	mouse	mouse	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	conj	_	_
26	respectively	respectively	RB	RB	_	9	advmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	predictor	predictor	NN	NN	_	3	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	sertraline	sertraline	NN	NN	_	8	compound	_	_
8	response	response	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	adolescent	adolescent	JJ	JJ	_	13	amod	_	_
11	major	major	JJ	JJ	_	13	amod	_	_
12	depressive	depressive	JJ	JJ	_	13	amod	_	_
13	disorder	disorder	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MDD	mdd	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	3	punct	_	_

1	Major	major	JJ	JJ	_	3	amod	_	_
2	depressive	depressive	JJ	JJ	_	3	amod	_	_
3	disorder	disorder	NN	NN	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	MDD	mdd	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	adolescents	adolescent	NNS	NNS	_	3	nmod	_	_
9	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
10	resistance	resistance	NN	NN	_	9	dobj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	tricyclic	tricyclic	JJ	JJ	_	13	amod	_	_
13	antidepressants	antidepressant	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	absence	absence	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	hypercortisolemia	hypercortisolemia	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	efficacy	efficacy	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	serotonin	serotonin	NN	NN	_	6	compound	_	_
5	reuptake	reuptake	NN	NN	_	6	compound	_	_
6	inhibitors	inhibitor	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	SRIs	sri	NNS	NNS	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	uncertain	uncertain	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	response	response	NN	NN	_	15	compound	_	_
15	predictors	predictor	NNS	NNS	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	unavailable	unavailable	JJ	JJ	_	11	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	3	amod	_	_
2	fast	fast	JJ	JJ	_	1	dep	_	_
3	feedback	feedback	NN	NN	_	11	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	feedback	feedback	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	10	amod	_	_
10	axis	axis	NN	NN	_	3	nmod	_	_
11	implicates	implicate	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	18	det	_	_
13	dampened	dampened	JJ	JJ	_	18	amod	_	_
14	limbic-hippocampal	limbic-hippocampal	JJ	JJ	_	18	amod	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	18	compound	_	_
16	type	type	NN	NN	_	18	compound	_	_
17	II	ii	CD	CD	_	18	nummod	_	_
18	receptor	receptor	NN	NN	_	11	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GCII	gcii	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	GCII	gcii	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	altered	alter	VBN	VBN	_	2	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	adolescent	adolescent	JJ	JJ	_	10	amod	_	_
10	MDD	mdd	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	could	could	MD	MD	_	13	aux	_	_
13	serve	serve	VB	VB	_	7	conj	_	_
14	as	as	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	marker	marker	NN	NN	_	13	nmod	_	_
17	for	for	IN	IN	_	18	case	_	_
18	response	response	NN	NN	_	16	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	SRIs	sri	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	an	a	DT	DT	_	4	det	_	_
3	open-label	open-label	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	adolescents	adolescent	NNS	NNS	_	17	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	n	n	NN	NN	_	6	dep	_	_
9	=	=	JJ	JJ	_	8	amod	_	_
10	20	20	CD	CD	_	9	dep	_	_
11	)	)	-RRB-	-RRB-	_	8	punct	_	_
12	meeting	meet	VBG	VBG	_	6	acl	_	_
13	DSM-III-R	dsm-iii-r	NN	NN	_	14	compound	_	_
14	criteria	criterion	NNS	NNS	_	12	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	MDD	mdd	NN	NN	_	14	nmod	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	baseline	baseline	NN	NN	_	27	compound	_	_
19	lymphocyte	lymphocyte	NN	NN	_	21	compound	_	_
20	GCII	gcii	NN	NN	_	21	compound	_	_
21	sites	site	NNS	NNS	_	18	dep	_	_
22	per	per	IN	IN	_	23	case	_	_
23	cell	cell	NN	NN	_	27	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	sites/cell	sites/cell	NNS	NNS	_	27	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	values	value	NNS	NNS	_	17	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	793	793	CD	CD	_	27	nmod	_	_
30	+/-	+/-	CC	CC	_	29	cc	_	_
31	106	106	CD	CD	_	29	conj	_	_
32	versus	versus	CC	CC	_	29	cc	_	_
33	2	2	CD	CD	_	29	conj	_	_
34	,	,	,	,	_	33	punct	_	_
35	563	563	CD	CD	_	33	nummod	_	_
36	+/-	+/-	CC	CC	_	33	cc	_	_
37	499	499	CD	CD	_	33	conj	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	+/-	+/-	CC	CC	_	40	cc	_	_
40	SEM	sem	NN	NN	_	33	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	for	for	IN	IN	_	44	case	_	_
43	matched	match	VBN	VBN	_	44	amod	_	_
44	controls	control	NNS	NNS	_	33	nmod	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	n	n	NN	NN	_	44	dep	_	_
47	=	=	JJ	JJ	_	46	amod	_	_
48	18	18	CD	CD	_	47	dep	_	_
49	)	)	-RRB-	-RRB-	_	46	punct	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	t	t	NN	NN	_	44	dep	_	_
52	=	=	JJ	JJ	_	51	amod	_	_
53	3.5	3.5	CD	CD	_	52	dep	_	_
54	;	;	:	:	_	51	punct	_	_
55	df	df	NN	NN	_	51	dep	_	_
56	=	=	JJ	JJ	_	55	amod	_	_
57	36	36	CD	CD	_	56	dep	_	_
58	;	;	:	:	_	51	punct	_	_
59	p	p	NN	NN	_	51	dep	_	_
60	&lt;	&lt;	JJR	JJR	_	59	amod	_	_
61	.001	.001	CD	CD	_	60	dep	_	_
62	)	)	-RRB-	-RRB-	_	51	punct	_	_
63	.	.	.	.	_	17	punct	_	_

1	GCII	gcii	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	bimodally	bimodally	RB	RB	_	4	advmod	_	_
4	distributed	distribute	VBN	VBN	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	with	with	IN	IN	_	9	mark	_	_
7	SRI	sri	NN	NN	_	8	compound	_	_
8	responders	responder	NNS	NNS	_	9	nsubj	_	_
9	differing	differ	VBG	VBG	_	4	advcl	_	_
10	from	from	IN	IN	_	11	case	_	_
11	nonresponders	nonresponder	NNS	NNS	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	t	t	NN	NN	_	11	dep	_	_
14	=	=	JJ	JJ	_	13	amod	_	_
15	3.9	3.9	CD	CD	_	14	dep	_	_
16	;	;	:	:	_	13	punct	_	_
17	df	df	NN	NN	_	13	dep	_	_
18	=	=	JJ	JJ	_	17	amod	_	_
19	14	14	CD	CD	_	18	dep	_	_
20	;	;	:	:	_	13	punct	_	_
21	p	p	NN	NN	_	13	dep	_	_
22	&lt;	&lt;	JJR	JJR	_	21	amod	_	_
23	.001	.001	CD	CD	_	22	dep	_	_
24	)	)	-RRB-	-RRB-	_	13	punct	_	_
25	.	.	.	.	_	4	punct	_	_

1	GCII	gcii	NN	NN	_	3	nsubj	_	_
2	accurately	accurately	RB	RB	_	3	advmod	_	_
3	classified	classify	VBD	VBD	_	0	root	_	_
4	90	90	CD	CD	_	5	nummod	_	_
5	percent	percent	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	sertraline	sertraline	NN	NN	_	8	compound	_	_
8	responders	responder	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	80	80	CD	CD	_	11	nummod	_	_
11	percent	percent	NN	NN	_	5	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	nonresponders	nonresponder	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	SRI	sri	NN	NN	_	3	compound	_	_
3	responders	responder	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	GCII	gcii	NN	NN	_	6	compound	_	_
6	sites/cell	sites/cell	NNS	NNS	_	4	dobj	_	_
7	upregulated	upregulate	VBN	VBN	_	6	acl	_	_
8	after	after	IN	IN	_	10	case	_	_
9	6	6	CD	CD	_	10	nummod	_	_
10	weeks	week	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	treatment	treatment	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	t	t	NN	NN	_	6	dep	_	_
15	=	=	JJ	JJ	_	14	amod	_	_
16	2.1	2.1	CD	CD	_	15	dep	_	_
17	,	,	,	,	_	14	punct	_	_
18	df	df	NN	NN	_	14	appos	_	_
19	=	=	JJ	JJ	_	18	amod	_	_
20	10	10	CD	CD	_	19	dep	_	_
21	;	;	:	:	_	14	punct	_	_
22	p	p	NN	NN	_	14	dep	_	_
23	&lt;	&lt;	JJR	JJR	_	22	amod	_	_
24	.05	.05	CD	CD	_	23	dep	_	_
25	)	)	-RRB-	-RRB-	_	14	punct	_	_
26	.	.	.	.	_	4	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	balance	balance	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transducer	transducer	NN	NN	_	21	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activator	activator	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	STAT	stat	NN	NN	_	11	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	4	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	cytokines	cytokine	NNS	NNS	_	1	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
26	synovial	synovial	JJ	JJ	_	27	amod	_	_
27	fluids	fluid	NNS	NNS	_	23	conj	_	_
28	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	balance	balance	NN	NN	_	13	nsubj	_	_
3	between	between	IN	IN	_	4	case	_	_
4	type	type	NN	NN	_	2	nmod	_	_
5	1	1	CD	CD	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	2	2	CD	CD	_	4	conj	_	_
8	T	t	NN	NN	_	12	compound	_	_
9	helper	helper	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	4	dep	_	_
13	plays	play	VBZ	VBZ	_	0	root	_	_
14	an	a	DT	DT	_	16	det	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	role	role	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	several	several	JJ	JJ	_	20	amod	_	_
19	animal	animal	JJ	JJ	_	20	amod	_	_
20	models	model	NNS	NNS	_	13	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	autoimmunity	autoimmunity	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	and	and	CC	CC	_	13	cc	_	_
25	skewed	skewed	JJ	JJ	_	26	amod	_	_
26	patterns	pattern	NNS	NNS	_	32	nsubjpass	_	_
27	of	of	IN	IN	_	29	case	_	_
28	cytokine	cytokine	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	nmod	_	_
30	have	have	VBP	VBP	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	described	describe	VBN	VBN	_	13	conj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	human	human	JJ	JJ	_	36	amod	_	_
35	inflammatory	inflammatory	JJ	JJ	_	36	amod	_	_
36	diseases	disease	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	Many	many	JJ	JJ	_	2	amod	_	_
2	cytokines	cytokine	NNS	NNS	_	3	nsubj	_	_
3	activate	activate	VBP	VBP	_	0	root	_	_
4	signal	signal	NN	NN	_	5	compound	_	_
5	transducer	transducer	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activation	activation	NN	NN	_	14	compound	_	_
8	of	of	IN	IN	_	14	amod	_	_
9	transcription	transcription	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	14	punct	_	_
11	STAT	stat	NN	NN	_	14	compound	_	_
12	)	)	-RRB-	-RRB-	_	14	punct	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	5	conj	_	_
15	,	,	,	,	_	3	punct	_	_
16	which	which	WDT	WDT	_	21	nsubj	_	_
17	,	,	,	,	_	21	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	turn	turn	NN	NN	_	21	nmod	_	_
20	,	,	,	,	_	21	punct	_	_
21	activate	activate	VBP	VBP	_	3	dep	_	_
22	transcription	transcription	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	inflammatory	inflammatory	JJ	JJ	_	26	amod	_	_
25	effector	effector	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	priming	priming	NN	NN	_	6	compound	_	_
6	cultures	culture	NNS	NNS	_	2	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
9	synovial	synovial	JJ	JJ	_	10	amod	_	_
10	fluids	fluid	NNS	NNS	_	6	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SFs	sf	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	derived	derive	VBN	VBN	_	10	acl	_	_
15	from	from	IN	IN	_	17	case	_	_
16	arthritis	arthritis	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	examine	examine	VB	VB	_	2	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	regulation	regulation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	cytokine	cytokine	NN	NN	_	24	compound	_	_
24	production	production	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	STAT	stat	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	conj	_	_
28	by	by	IN	IN	_	32	case	_	_
29	an	a	DT	DT	_	32	det	_	_
30	inflammatory	inflammatory	JJ	JJ	_	32	amod	_	_
31	synovial	synovial	JJ	JJ	_	32	amod	_	_
32	microenvironment	microenvironment	NN	NN	_	21	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Exposure	exposure	NN	NN	_	6	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	SFs	sf	NNS	NNS	_	1	nmod	_	_
4	during	during	IN	IN	_	5	case	_	_
5	priming	priming	NN	NN	_	1	nmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	81	81	CD	CD	_	10	compound	_	_
10	%	%	NN	NN	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	interferon	interferon	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	IFN	ifn	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	-gamma	-gamma	NN	NN	_	11	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	17	cc	_	_
21	interleukin	interleukin	NN	NN	_	23	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	IL	il	NN	NN	_	17	conj	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	4	4	CD	CD	_	23	nummod	_	_
26	,	,	,	,	_	17	punct	_	_
27	production	production	NN	NN	_	17	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	effector	effector	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	11	nmod	_	_
31	generated	generate	VBN	VBN	_	30	acl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	priming	priming	JJ	JJ	_	34	amod	_	_
34	cultures	culture	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	SF	sf	NN	NN	_	2	compound	_	_
2	suppression	suppression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-10	il-10	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	inhibition	inhibition	NN	NN	_	6	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	IL-12	il-12	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	it	it	PRP	PRP	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	reversed	reverse	VBN	VBN	_	4	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	dominant	dominant	JJ	JJ	_	22	amod	_	_
22	fashion	fashion	NN	NN	_	18	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	exogenous	exogenous	JJ	JJ	_	25	amod	_	_
25	IL-12	il-12	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	SFs	sf	NNS	NNS	_	2	nsubj	_	_
2	blocked	block	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	sustained	sustained	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	Stat1	stat1	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	Stat3	stat3	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	2	punct	_	_
15	during	during	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	priming	priming	NN	NN	_	18	compound	_	_
18	period	period	NN	NN	_	2	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	and	and	CC	CC	_	2	cc	_	_
21	Stat1	stat1	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	25	nsubjpass	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	differentially	differentially	RB	RB	_	25	advmod	_	_
25	regulated	regulate	VBN	VBN	_	2	conj	_	_
26	by	by	IN	IN	_	27	case	_	_
27	cytokines	cytokine	NNS	NNS	_	25	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	parallel	parallel	NN	NN	_	25	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
32	positive	positive	JJ	JJ	_	29	nmod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	negative	negative	JJ	JJ	_	32	conj	_	_
35	regulation	regulation	NN	NN	_	32	dep	_	_
36	of	of	IN	IN	_	38	case	_	_
37	IFN-gamma	ifn-gamma	NN	NN	_	38	compound	_	_
38	production	production	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	Active	active	JJ	JJ	_	2	amod	_	_
2	Stat3	stat3	NN	NN	_	9	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	Stat1	stat1	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	9	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	inflamed	inflamed	JJ	JJ	_	14	amod	_	_
14	joints	joint	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	altered	altered	JJ	JJ	_	8	amod	_	_
8	balance	balance	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Stat1	stat1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Stat3	stat3	NN	NN	_	10	conj	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	10	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regulation	regulation	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	pathogenesis	pathogenesis	NN	NN	_	17	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	inflammatory	inflammatory	JJ	JJ	_	28	amod	_	_
28	synovitis	synovitis	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Anti-immunoglobulin	anti-immunoglobulin	NN	NN	_	2	compound	_	_
2	M	m	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
5	calcium	calcium	NN	NN	_	8	compound	_	_
6	/calmodulin-dependent	/calmodulin-dependent	JJ	JJ	_	8	amod	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	kinase	kinase	NN	NN	_	3	dobj	_	_
9	II	ii	CD	CD	_	8	nummod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	others	other	NNS	NNS	_	1	conj	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	previously	previously	RB	RB	_	6	advmod	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	15	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	Ets-1	ets-1	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	phosphorylated	phosphorylate	VBN	VBN	_	6	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	calcium-dependent	calcium-dependent	JJ	JJ	_	19	amod	_	_
19	manner	manner	NN	NN	_	15	nmod	_	_
20	after	after	IN	IN	_	21	case	_	_
21	ligation	ligation	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	immunoglobulin	immunoglobulin	NN	NN	_	27	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	Ig	ig	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	M	m	NN	NN	_	21	nmod	_	_
28	on	on	IN	IN	_	30	case	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	As	as	IN	IN	_	5	mark	_	_
2	this	this	DT	DT	_	3	det	_	_
3	phosphorylation	phosphorylation	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	independent	independent	JJ	JJ	_	13	advcl	_	_
6	of	of	IN	IN	_	10	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	C	c	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	tested	test	VBD	VBD	_	0	root	_	_
14	whether	whether	IN	IN	_	25	mark	_	_
15	a	a	DT	DT	_	19	det	_	_
16	calcium	calcium	NN	NN	_	19	compound	_	_
17	/calmodulin-dependent	/calmodulin-dependent	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	25	nsubj	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	CaM	cam	NN	NN	_	22	compound	_	_
22	kinase	kinase	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	might	might	MD	MD	_	25	aux	_	_
25	phosphorylate	phosphorylate	VB	VB	_	13	ccomp	_	_
26	the	the	DT	DT	_	28	det	_	_
27	Ets-1	ets-1	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	25	dobj	_	_
29	after	after	IN	IN	_	30	case	_	_
30	elevation	elevation	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	intracellular	intracellular	JJ	JJ	_	35	amod	_	_
33	free	free	JJ	JJ	_	32	dep	_	_
34	calcium	calcium	NN	NN	_	35	compound	_	_
35	concentrations	concentration	NNS	NNS	_	30	nmod	_	_
36	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dephosphorylated	dephosphorylated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Ets-1	ets-1	NN	NN	_	3	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	bind	bind	VB	VB	_	8	xcomp	_	_
11	to	to	TO	TO	_	12	case	_	_
12	chromatin	chromatin	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	operative	operative	JJ	JJ	_	18	amod	_	_
18	kinase	kinase	NN	NN	_	21	nsubj	_	_
19	should	should	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	detectable	detectable	JJ	JJ	_	14	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	nucleus	nucleus	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	prepared	prepare	VBD	VBD	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	extracts	extract	NNS	NNS	_	2	dobj	_	_
5	from	from	IN	IN	_	10	case	_	_
6	two	two	CD	CD	_	10	nummod	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	18	nmod	_	_
13	increased	increase	VBN	VBN	_	17	amod	_	_
14	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
15	free	free	JJ	JJ	_	14	dep	_	_
16	calcium	calcium	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	18	nsubj	_	_
18	correlated	correlate	VBD	VBD	_	10	acl:relcl	_	_
19	with	with	IN	IN	_	21	case	_	_
20	increased	increase	VBN	VBN	_	21	amod	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	Ets-1	ets-1	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Activity	activity	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CaM	cam	NN	NN	_	5	compound	_	_
5	kinases	kinase	NNS	NNS	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	determined	determine	VBN	VBN	_	0	root	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
11	peptide	peptide	NN	NN	_	12	compound	_	_
12	substrate	substrate	NN	NN	_	8	dobj	_	_
13	both	both	CC	CC	_	16	dep	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	absence	absence	NN	NN	_	8	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	presence	presence	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	inhibitor	inhibitor	NN	NN	_	16	nmod	_	_
22	specific	specific	JJ	JJ	_	21	amod	_	_
23	for	for	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	CaM	cam	NN	NN	_	27	compound	_	_
26	kinase	kinase	NN	NN	_	27	compound	_	_
27	family	family	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	KN-62	kn-62	NN	NN	_	27	appos	_	_
30	.	.	.	.	_	7	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	anti-IgM	anti-igm	NN	NN	_	1	nmod	_	_
6	led	lead	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	kinase	kinase	NN	NN	_	9	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	could	could	MD	MD	_	16	aux	_	_
16	phosphorylate	phosphorylate	VB	VB	_	13	acl:relcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	peptide	peptide	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	6	punct	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	this	this	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	reduced	reduce	VBN	VBN	_	6	conj	_	_
25	by	by	IN	IN	_	28	case	_	_
26	10	10	CD	CD	_	27	compound	_	_
27	microM	microm	NN	NN	_	28	amod	_	_
28	KN-62	kn-62	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Kinase	kinase	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	reduced	reduce	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	lysates	lysate	NNS	NNS	_	4	nmod	_	_
7	preadsorbed	preadsorb	VBN	VBN	_	6	acl	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	an	a	DT	DT	_	10	det	_	_
10	antibody	antibody	NN	NN	_	8	dobj	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	CaM	cam	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	11	nmod	_	_
15	II	ii	CD	CD	_	14	nummod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Two-dimensional	two-dimensional	JJ	JJ	_	3	amod	_	_
2	phosphopeptide	phosphopeptide	NN	NN	_	3	compound	_	_
3	maps	map	NNS	NNS	_	15	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Ets-1	ets-1	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	incubated	incubate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	ionomycin	ionomycin	NN	NN	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	anti-IgM	anti-igm	NN	NN	_	12	conj	_	_
15	contained	contain	VBD	VBD	_	0	root	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	unique	unique	JJ	JJ	_	18	amod	_	_
18	phosphopeptides	phosphopeptide	NNS	NNS	_	15	dobj	_	_
19	that	that	WDT	WDT	_	21	nsubj	_	_
20	were	be	VBD	VBD	_	21	cop	_	_
21	absent	absent	JJ	JJ	_	18	acl:relcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	untreated	untreated	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Incubation	incubation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	isolated	isolate	VBN	VBN	_	5	amod	_	_
4	Ets-1	ets-1	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	purified	purify	VBN	VBN	_	9	amod	_	_
8	CaM	cam	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	1	nmod	_	_
10	II	ii	CD	CD	_	9	nummod	_	_
11	produced	produce	VBD	VBD	_	0	root	_	_
12	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	peptides	peptide	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	migrated	migrate	VBD	VBD	_	14	acl:relcl	_	_
17	identically	identically	RB	RB	_	16	advmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	those	those	DT	DT	_	16	nmod	_	_
20	found	find	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	22	case	_	_
22	cells	cell	NNS	NNS	_	20	nmod	_	_
23	incubated	incubate	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	anti-IgM	anti-igm	NN	NN	_	23	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	ionomycin	ionomycin	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transduction	transduction	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	antigen	antigen	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	8	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	24	nmod	_	_
18	increased	increase	VBN	VBN	_	21	amod	_	_
19	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
20	free	free	JJ	JJ	_	19	dep	_	_
21	calcium	calcium	NN	NN	_	24	nsubj	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	rapidly	rapidly	RB	RB	_	24	advmod	_	_
24	activate	activate	VB	VB	_	15	acl:relcl	_	_
25	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
26	CaM	cam	NN	NN	_	27	compound	_	_
27	kinase	kinase	NN	NN	_	24	dobj	_	_
28	II	ii	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	24	punct	_	_
30	potentially	potentially	RB	RB	_	31	advmod	_	_
31	resulting	result	VBG	VBG	_	24	advcl	_	_
32	in	in	IN	IN	_	33	case	_	_
33	phosphorylation	phosphorylation	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	regulation	regulation	NN	NN	_	33	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	DNA-binding	dna-binding	JJ	JJ	_	38	amod	_	_
38	proteins	protein	NNS	NNS	_	33	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	repression	repression	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	properties	property	NNS	NNS	_	2	appos	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	lymphoid-specific	lymphoid-specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	7	nmod	_	_
13	Oct-2a	oct-2a	NN	NN	_	12	dep	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	lymphoid-specific	lymphoid-specific	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	6	nsubj	_	_
5	Oct-2a	oct-2a	NN	NN	_	4	dep	_	_
6	contains	contain	VBZ	VBZ	_	0	root	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	activation	activation	NN	NN	_	10	compound	_	_
10	domains	domain	NNS	NNS	_	6	dobj	_	_
11	which	which	WDT	WDT	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	located	located	JJ	JJ	_	10	acl:relcl	_	_
14	within	within	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	N-terminal	n-terminal	JJ	JJ	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	C-terminal	c-terminal	JJ	JJ	_	19	amod	_	_
19	regions	region	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	their	they	PRP$	PRP$	_	6	nmod:poss	_	_
4	differential	differential	JJ	JJ	_	6	amod	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	properties	property	NNS	NNS	_	2	dobj	_	_
7	,	,	,	,	_	2	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	linked	link	VBD	VBD	_	2	parataxis	_	_
10	the	the	DT	DT	_	13	det	_	_
11	isolated	isolate	VBN	VBN	_	13	amod	_	_
12	effector	effector	NN	NN	_	13	compound	_	_
13	domains	domain	NNS	NNS	_	9	dobj	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	GAL4	gal4	NN	NN	_	18	compound	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	both	both	DT	DT	_	7	det	_	_
6	activating	activate	VBG	VBG	_	7	amod	_	_
7	regions	region	NNS	NNS	_	18	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Oct-2a	oct-2a	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	isolated	isolate	VBN	VBN	_	7	acl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	natural	natural	JJ	JJ	_	15	amod	_	_
15	context	context	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	activate	activate	VB	VB	_	3	ccomp	_	_
19	transcription	transcription	NN	NN	_	18	dobj	_	_
20	as	as	IN	IN	_	22	case	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	C-terminus	c-terminus	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	activation	activation	NN	NN	_	13	nsubj	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	dependent	dependent	JJ	JJ	_	0	root	_	_
14	on	on	IN	IN	_	20	case	_	_
15	a	a	DT	DT	_	20	det	_	_
16	yet	yet	RB	RB	_	17	advmod	_	_
17	unidentified	unidentified	JJ	JJ	_	20	amod	_	_
18	factor	factor	NN	NN	_	20	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	s	s	NNS	NNS	_	13	nmod	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	binding	bind	VBG	VBG	_	20	acl	_	_
23	to	to	TO	TO	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	simian	simian	JJ	JJ	_	28	amod	_	_
26	virus	virus	NN	NN	_	28	compound	_	_
27	40	40	CD	CD	_	28	nummod	_	_
28	enhancer	enhancer	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	13	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	5	case	_	_
5	duplication	duplication	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	activation	activation	NN	NN	_	8	compound	_	_
8	domains	domain	NNS	NNS	_	5	nmod	_	_
9	or	or	CC	CC	_	5	cc	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	mixed	mixed	JJ	JJ	_	12	amod	_	_
12	combination	combination	NN	NN	_	5	conj	_	_
13	suggest	suggest	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	the	the	DT	DT	_	16	det	_	_
16	domains	domain	NNS	NNS	_	19	nsubj	_	_
17	are	be	VBP	VBP	_	19	cop	_	_
18	functionally	functionally	RB	RB	_	19	advmod	_	_
19	independent	independent	JJ	JJ	_	13	ccomp	_	_
20	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	activation	activation	NN	NN	_	11	nsubjpass	_	_
4	from	from	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	remote	remote	JJ	JJ	_	7	amod	_	_
7	position	position	NN	NN	_	3	nmod	_	_
8	could	could	MD	MD	_	11	aux	_	_
9	only	only	RB	RB	_	11	advmod	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	achieved	achieve	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	C-terminus	c-terminus	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Oct-2a	oct-2a	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	higher	higher	JJR	JJR	_	7	amod	_	_
6	activation	activation	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
12	that	that	IN	IN	_	26	mark	_	_
13	distinct	distinct	JJ	JJ	_	15	amod	_	_
14	B-cell-specific	b-cell-specific	JJ	JJ	_	15	amod	_	_
15	cofactors	cofactor	NNS	NNS	_	26	nsubjpass	_	_
16	in	in	IN	IN	_	17	case	_	_
17	concert	concert	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	effector	effector	NN	NN	_	21	compound	_	_
21	domains	domain	NNS	NNS	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Oct-2a	oct-2a	NN	NN	_	21	nmod	_	_
24	might	might	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	involved	involve	VBN	VBN	_	11	ccomp	_	_
27	in	in	IN	IN	_	28	mark	_	_
28	mediating	mediate	VBG	VBG	_	26	advcl	_	_
29	transcription	transcription	NN	NN	_	28	dobj	_	_
30	from	from	IN	IN	_	31	case	_	_
31	proximal	proximal	JJ	JJ	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	remote	remote	JJ	JJ	_	31	conj	_	_
34	positions	position	NNS	NNS	_	31	dep	_	_
35	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	repression	repression	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	4	dobj	_	_
8	at	at	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	N-terminus	n-terminus	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Oct-2a	oct-2a	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	transferred	transfer	VBN	VBN	_	11	advcl	_	_
3	to	to	TO	TO	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	stimulation	stimulation	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	efficiently	efficiently	RB	RB	_	11	advmod	_	_
13	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	underscore	underscore	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	modular	modular	JJ	JJ	_	6	amod	_	_
6	structure	structure	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Oct-2a	oct-2a	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	separable	separable	JJ	JJ	_	11	amod	_	_
11	domains	domain	NNS	NNS	_	6	nmod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	repression	repression	NN	NN	_	13	conj	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	suggest	suggest	VBP	VBP	_	3	conj	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	Oct-2a	oct-2a	NN	NN	_	21	nsubj	_	_
20	might	might	MD	MD	_	21	aux	_	_
21	have	have	VB	VB	_	17	ccomp	_	_
22	complex	complex	JJ	JJ	_	24	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	functions	function	NNS	NNS	_	21	dobj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	21	advmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Solution	solution	NN	NN	_	2	compound	_	_
2	structure	structure	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	sequence-specific	sequence-specific	JJ	JJ	_	7	amod	_	_
6	HMG	hmg	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	lymphocyte	lymphocyte	NN	NN	_	12	compound	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activator	activator	NN	NN	_	7	nmod	_	_
13	Sox-4	sox-4	NN	NN	_	12	dep	_	_
14	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	groups	group	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HMG	hmg	NN	NN	_	6	compound	_	_
5	box	box	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	distinguished	distinguish	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Proteins	protein	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	group	group	NN	NN	_	1	nmod	_	_
6	contain	contain	VBP	VBP	_	0	root	_	_
7	multiple	multiple	JJ	JJ	_	9	amod	_	_
8	HMG	hmg	NN	NN	_	9	compound	_	_
9	boxes	box	NNS	NNS	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	non-sequence-specific	non-sequence-specific	JJ	JJ	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	recognize	recognize	VBP	VBP	_	6	conj	_	_
16	structural	structural	JJ	JJ	_	17	amod	_	_
17	features	feature	NNS	NNS	_	15	dobj	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	found	find	VBN	VBN	_	15	advcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	cruciform	cruciform	JJ	JJ	_	22	amod	_	_
22	DNA	dna	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	cross-over	cross-over	JJ	JJ	_	25	amod	_	_
25	DNA	dna	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	abundant	abundant	JJ	JJ	_	4	amod	_	_
3	chromosomal	chromosomal	JJ	JJ	_	4	amod	_	_
4	protein	protein	NN	NN	_	6	nsubj	_	_
5	HMG-1	hmg-1	NN	NN	_	4	dep	_	_
6	belongs	belong	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	subgroup	subgroup	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Proteins	protein	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	second	second	JJ	JJ	_	5	amod	_	_
5	group	group	NN	NN	_	1	nmod	_	_
6	carry	carry	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	single	single	JJ	JJ	_	10	amod	_	_
9	HMG	hmg	NN	NN	_	10	compound	_	_
10	box	box	NN	NN	_	6	dobj	_	_
11	with	with	IN	IN	_	12	case	_	_
12	affinity	affinity	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	minor	minor	JJ	JJ	_	16	amod	_	_
16	groove	groove	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	heptamer	heptamer	NN	NN	_	20	compound	_	_
20	motif	motif	NN	NN	_	16	nmod	_	_
21	AACAAAG	aacaaag	NN	NN	_	20	dep	_	_
22	or	or	CC	CC	_	20	cc	_	_
23	variations	variation	NNS	NNS	_	20	conj	_	_
24	thereof	thereof	RB	RB	_	23	advmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	solution	solution	NN	NN	_	3	compound	_	_
3	structure	structure	NN	NN	_	15	nsubjpass	_	_
4	for	for	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	non-sequence-specific	non-sequence-specific	JJ	JJ	_	9	amod	_	_
7	C-terminal	c-terminal	JJ	JJ	_	9	amod	_	_
8	HMG	hmg	NN	NN	_	9	compound	_	_
9	box	box	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	HMG-1	hmg-1	NN	NN	_	9	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	recently	recently	RB	RB	_	15	advmod	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	proposed	propose	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Now	now	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	solution	solution	NN	NN	_	7	compound	_	_
7	structure	structure	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	sequence-specific	sequence-specific	JJ	JJ	_	11	amod	_	_
11	HMG-box	hmg-box	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	SRY-related	sry-related	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	11	nmod	_	_
16	Sox-4	sox-4	NN	NN	_	15	dep	_	_
17	.	.	.	.	_	4	punct	_	_

1	NMR	nmr	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	three	three	CD	CD	_	8	nummod	_	_
8	alpha-helices	alpha-helix	NNS	NNS	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Val10-Gln22	val10-gln22	NN	NN	_	8	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	Glu30-Leu41	glu30-leu41	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	Phe50-Tyr65	phe50-tyr65	NN	NN	_	10	conj	_	_
15	)	)	-RRB-	-RRB-	_	10	punct	_	_
16	connected	connect	VBN	VBN	_	8	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	loop	loop	NN	NN	_	19	compound	_	_
19	regions	region	NNS	NNS	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Ser23-Ala49	ser23-ala49	NN	NN	_	19	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Leu42-Pro49	leu42-pro49	NN	NN	_	21	conj	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	Helices	helix	NNS	NNS	_	6	nsubj	_	_
2	I	i	CD	CD	_	1	dep	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	II	ii	CD	CD	_	1	conj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	positioned	positioned	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	antiparallel	antiparallel	JJ	JJ	_	10	amod	_	_
10	mode	mode	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	form	form	VBP	VBP	_	6	conj	_	_
13	one	one	CD	CD	_	14	nummod	_	_
14	arm	arm	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HMG	hmg	NN	NN	_	18	compound	_	_
18	box	box	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Helix	helix	NN	NN	_	5	nsubj	_	_
2	III	iii	CD	CD	_	1	nummod	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	less	less	RBR	RBR	_	5	advmod	_	_
5	rigid	rigid	JJ	JJ	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	makes	make	VBZ	VBZ	_	5	conj	_	_
8	an	a	DT	DT	_	10	det	_	_
9	average	average	JJ	JJ	_	10	amod	_	_
10	angle	angle	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	about	about	RB	RB	_	13	advmod	_	_
13	90	90	CD	CD	_	14	nummod	_	_
14	degrees	degree	NNS	NNS	_	10	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	helices	helix	NNS	NNS	_	10	nmod	_	_
17	I	i	CD	CD	_	16	dep	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	II	ii	CD	CD	_	16	conj	_	_
20	,	,	,	,	_	5	punct	_	_
21	and	and	CC	CC	_	5	cc	_	_
22	constitutes	constitute	VBZ	VBZ	_	5	conj	_	_
23	the	the	DT	DT	_	25	det	_	_
24	other	other	JJ	JJ	_	25	amod	_	_
25	arm	arm	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	molecule	molecule	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	in	in	IN	IN	_	3	case	_	_
3	HMG1B	hmg1b	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	overall	overall	JJ	JJ	_	7	amod	_	_
7	structure	structure	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	Sox-4	sox-4	NN	NN	_	7	nmod	_	_
11	HMG	hmg	NN	NN	_	12	compound	_	_
12	box	box	NN	NN	_	10	dep	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	L-shaped	l-shaped	JJ	JJ	_	0	root	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	maintained	maintain	VBN	VBN	_	14	conj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	cluster	cluster	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	conserved	conserve	VBN	VBN	_	26	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	mainly	mainly	RB	RB	_	25	advmod	_	_
25	aromatic	aromatic	JJ	JJ	_	22	dep	_	_
26	residues	residue	NNS	NNS	_	20	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	Dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	2	compound	_	_
2	modulation	modulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	6	amod	_	_
5	monocyte	monocyte	NN	NN	_	6	compound	_	_
6	cytotoxicity	cytotoxicity	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Dehydroepiandrosterone	dehydroepiandrosterone	NN	NN	_	17	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	DHEA	dhea	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	predominant	predominant	JJ	JJ	_	8	amod	_	_
8	androgen	androgen	NN	NN	_	1	appos	_	_
9	secreted	secrete	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	adrenal	adrenal	JJ	JJ	_	13	amod	_	_
13	cortex	cortex	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	can	can	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	converted	convert	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	21	case	_	_
19	both	both	CC	CC	_	21	cc:preconj	_	_
20	potent	potent	JJ	JJ	_	21	dep	_	_
21	androgens	androgen	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	estrogens	estrogen	NNS	NNS	_	21	conj	_	_
24	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
5	role	role	NN	NN	_	2	nmod	_	_
6	as	as	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	precursor	precursor	NN	NN	_	5	nmod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	other	other	JJ	JJ	_	12	amod	_	_
11	steroid	steroid	NN	NN	_	12	compound	_	_
12	hormones	hormone	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	DHEA	dhea	NN	NN	_	17	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	proposed	propose	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	play	play	VB	VB	_	17	xcomp	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	immunity	immunity	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	DHEA	dhea	NN	NN	_	6	compound	_	_
6	modulation	modulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	LPS-induced	lps-induced	JJ	JJ	_	10	amod	_	_
9	monocyte	monocyte	NN	NN	_	10	compound	_	_
10	cytotoxicity	cytotoxicity	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Cytotoxicity	cytotoxicity	NN	NN	_	2	compound	_	_
2	markers	marker	NNS	NNS	_	4	nsubj	_	_
3	assessed	assess	VBN	VBN	_	2	acl	_	_
4	include	include	VBP	VBP	_	0	root	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	killing	killing	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-1	il-1	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	7	appos	_	_
11	,	,	,	,	_	7	punct	_	_
12	reactive	reactive	JJ	JJ	_	15	amod	_	_
13	oxygen	oxygen	NN	NN	_	15	compound	_	_
14	intermediate	intermediate	JJ	JJ	_	15	amod	_	_
15	release	release	NN	NN	_	7	appos	_	_
16	,	,	,	,	_	7	punct	_	_
17	nitric	nitric	JJ	JJ	_	19	amod	_	_
18	oxide	oxide	NN	NN	_	19	compound	_	_
19	synthetase	synthetase	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	7	appos	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	measured	measure	VBN	VBN	_	7	dep	_	_
23	by	by	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	release	release	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	reactive	reactive	JJ	JJ	_	29	amod	_	_
28	nitrogen	nitrogen	NN	NN	_	29	compound	_	_
29	intermediates	intermediate	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	complement	complement	NN	NN	_	35	compound	_	_
32	receptor-1	receptor-1	NN	NN	_	35	compound	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	surface	surface	NN	NN	_	35	compound	_	_
35	protein	protein	NN	NN	_	29	appos	_	_
36	,	,	,	,	_	25	punct	_	_
37	and	and	CC	CC	_	25	cc	_	_
38	TNF-alpha	tnf-alpha	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	40	compound	_	_
40	presence	presence	NN	NN	_	25	conj	_	_
41	.	.	.	.	_	4	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	9	nsubj	_	_
2	stimulated	stimulate	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	5	case	_	_
4	LPS	lps	NN	NN	_	5	compound	_	_
5	concentrations	concentration	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	1.0	1.0	CD	CD	_	8	nummod	_	_
8	micrograms/ml	micrograms/ml	NNS	NNS	_	5	nmod	_	_
9	displayed	display	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	13	det	_	_
11	above	above	JJ	JJ	_	13	amod	_	_
12	cytotoxic	cytotoxic	JJ	JJ	_	13	amod	_	_
13	markers	marker	NNS	NNS	_	9	dobj	_	_
14	,	,	,	,	_	9	punct	_	_
15	whereas	whereas	IN	IN	_	31	mark	_	_
16	monocytes	monocyte	NNS	NNS	_	31	nsubj	_	_
17	stimulated	stimulate	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	DHEA	dhea	NN	NN	_	17	nmod	_	_
20	alone	alone	RB	RB	_	19	advmod	_	_
21	or	or	CC	CC	_	19	cc	_	_
22	with	with	IN	IN	_	23	case	_	_
23	LPS	lps	NN	NN	_	19	conj	_	_
24	at	at	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	lower	lower	JJR	JJR	_	27	amod	_	_
27	concentration	concentration	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	0.2	0.2	CD	CD	_	30	nummod	_	_
30	ng/ml	ng/ml	NN	NN	_	27	nmod	_	_
31	did	do	VBD	VBD	_	9	advcl	_	_
32	not	not	RB	RB	_	31	neg	_	_
33	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	when	when	WRB	WRB	_	4	advmod	_	_
4	used	use	VBN	VBN	_	12	advcl	_	_
5	simultaneously	simultaneously	RB	RB	_	4	advmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	DHEA	dhea	NN	NN	_	12	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	LPS	lps	NN	NN	_	7	conj	_	_
10	0.2	0.2	CD	CD	_	11	compound	_	_
11	ng/ml	ng/ml	NN	NN	_	9	amod	_	_
12	displayed	display	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	synergistic	synergistic	JJ	JJ	_	15	amod	_	_
15	effect	effect	NN	NN	_	12	dobj	_	_
16	on	on	IN	IN	_	18	case	_	_
17	monocyte	monocyte	NN	NN	_	18	compound	_	_
18	cytotoxicity	cytotoxicity	NN	NN	_	15	nmod	_	_
19	against	against	IN	IN	_	22	case	_	_
20	cancerous	cancerous	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	IL-1	il-1	NN	NN	_	25	compound	_	_
25	secretion	secretion	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	reactive	reactive	JJ	JJ	_	30	amod	_	_
28	nitrogen	nitrogen	NN	NN	_	30	compound	_	_
29	intermediate	intermediate	JJ	JJ	_	30	amod	_	_
30	release	release	NN	NN	_	22	conj	_	_
31	,	,	,	,	_	22	punct	_	_
32	complement	complement	NN	NN	_	35	compound	_	_
33	receptor-1	receptor-1	NN	NN	_	35	compound	_	_
34	cell-surface	cell-surface	NN	NN	_	35	compound	_	_
35	protein	protein	NN	NN	_	22	conj	_	_
36	,	,	,	,	_	22	punct	_	_
37	and	and	CC	CC	_	22	cc	_	_
38	TNF-alpha	tnf-alpha	NN	NN	_	39	compound	_	_
39	protein	protein	NN	NN	_	22	conj	_	_
40	to	to	TO	TO	_	41	case	_	_
41	levels	level	NNS	NNS	_	12	nmod	_	_
42	comparable	comparable	JJ	JJ	_	41	amod	_	_
43	with	with	IN	IN	_	44	case	_	_
44	levels	level	NNS	NNS	_	42	nmod	_	_
45	obtained	obtain	VBN	VBN	_	44	acl	_	_
46	using	use	VBG	VBG	_	45	xcomp	_	_
47	LPS	lps	NN	NN	_	46	dobj	_	_
48	1.0	1.0	CD	CD	_	49	compound	_	_
49	microgram/ml	microgram/ml	NN	NN	_	47	amod	_	_
50	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	Scatchard	scatchard	NN	NN	_	5	compound	_	_
4	plot	plot	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	DHEA	dhea	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	DHEA	dhea	NN	NN	_	19	compound	_	_
19	effects	effect	NNS	NNS	_	24	nsubjpass	_	_
20	on	on	IN	IN	_	22	case	_	_
21	LPS-stimulated	lps-stimulated	JJ	JJ	_	22	amod	_	_
22	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	mediated	mediate	VBN	VBN	_	16	ccomp	_	_
25	through	through	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	receptor-dependent	receptor-dependent	JJ	JJ	_	28	amod	_	_
28	process	process	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	BSAP	bsap	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	key	key	JJ	JJ	_	5	amod	_	_
5	regulator	regulator	NN	NN	_	1	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	B-cell	b-cell	NN	NN	_	5	nmod	_	_
8	development	development	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	differentiation	differentiation	NN	NN	_	7	conj	_	_
11	.	.	.	.	_	1	punct	_	_

1	B-cell-specific	b-cell-specific	JJ	JJ	_	3	amod	_	_
2	activator	activator	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	11	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	BSAP	bsap	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	recently	recently	RB	RB	_	10	advmod	_	_
10	identified	identify	VBN	VBN	_	11	amod	_	_
11	member	member	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Pax-gene	pax-gene	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	15	nmod	_	_
19	;	;	:	:	_	11	punct	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	system	system	NN	NN	_	27	nmod	_	_
24	,	,	,	,	_	27	punct	_	_
25	BSAP	bsap	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	produced	produce	VBN	VBN	_	11	parataxis	_	_
28	only	only	RB	RB	_	31	advmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	Markus	Markus	NNP	NNP	_	4	compound	_	_
4	Neurath	Neurath	NNP	NNP	_	11	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	Eckhard	Eckhard	NNP	NNP	_	7	compound	_	_
7	Stuber	Stuber	NNP	NNP	_	4	conj	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	Warren	Warren	NNP	NNP	_	10	compound	_	_
10	Strober	Strober	NNP	NNP	_	4	conj	_	_
11	describe	describe	VBP	VBP	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	structure	structure	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	BSAP	bsap	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	focus	focus	VBP	VBP	_	11	conj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	ability	ability	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	protein	protein	NN	NN	_	21	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	regulate	regulate	VB	VB	_	21	acl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	B-cell-specific	b-cell-specific	JJ	JJ	_	31	amod	_	_
31	genes	gene	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	BSAP	bsap	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	key	key	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	2	ccomp	_	_
9	of	of	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	it	it	PRP	PRP	_	17	nsubj	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	only	only	RB	RB	_	17	cc:preconj	_	_
17	influence	influence	VBP	VBP	_	8	conj	_	_
18	B-cell	b-cell	NN	NN	_	19	compound	_	_
19	development	development	NN	NN	_	17	dobj	_	_
20	but	but	CC	CC	_	17	cc	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	influences	influence	VBZ	VBZ	_	17	conj	_	_
23	the	the	DT	DT	_	24	det	_	_
24	balance	balance	NN	NN	_	22	dobj	_	_
25	between	between	IN	IN	_	27	case	_	_
26	B-cell	b-cell	NN	NN	_	27	compound	_	_
27	proliferation	proliferation	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	immunoglobulin	immunoglobulin	NN	NN	_	30	compound	_	_
30	secretion	secretion	NN	NN	_	27	conj	_	_
31	at	at	IN	IN	_	33	case	_	_
32	later	later	JJR	JJR	_	33	amod	_	_
33	stages	stage	NNS	NNS	_	22	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	B-cell	b-cell	NN	NN	_	36	compound	_	_
36	differentiation	differentiation	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BSAP	bsap	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	Pax-5	pax-5	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B-cell	b-cell	NN	NN	_	10	compound	_	_
10	development	development	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	hierarchy	hierarchy	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	control	control	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	B-cell	b-cell	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	5	nmod	_	_
9	has	have	VBZ	VBZ	_	12	aux	_	_
10	recently	recently	RB	RB	_	12	advmod	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	analyzed	analyze	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	targeted	target	VBN	VBN	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	inactivation	inactivation	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	mouse	mouse	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	manner	manner	NN	NN	_	23	nmod	_	_
4	,	,	,	,	_	23	punct	_	_
5	the	the	DT	DT	_	9	det	_	_
6	paired	paired	JJ	JJ	_	9	amod	_	_
7	box	box	NN	NN	_	9	compound	_	_
8	containing	contain	VBG	VBG	_	9	amod	_	_
9	gene	gene	NN	NN	_	23	nsubjpass	_	_
10	Pax-5	pax-5	NN	NN	_	9	dep	_	_
11	,	,	,	,	_	9	punct	_	_
12	encoding	encode	VBG	VBG	_	9	acl	_	_
13	the	the	DT	DT	_	18	det	_	_
14	B	b	NN	NN	_	18	compound	_	_
15	cell	cell	NN	NN	_	18	compound	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	12	dobj	_	_
19	BSAP	bsap	NN	NN	_	18	dep	_	_
20	,	,	,	,	_	9	punct	_	_
21	has	have	VBZ	VBZ	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	shown	show	VBN	VBN	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	play	play	VB	VB	_	23	xcomp	_	_
26	a	a	DT	DT	_	28	det	_	_
27	key	key	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	early	early	JJ	JJ	_	32	amod	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	lymphopoiesis	lymphopoiesis	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	23	punct	_	_

1	Other	other	JJ	JJ	_	3	amod	_	_
2	experimental	experimental	JJ	JJ	_	3	amod	_	_
3	strategies	strategy	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	implicated	implicate	VBN	VBN	_	0	root	_	_
6	BSAP	bsap	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	control	control	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	isotype	isotype	NN	NN	_	15	compound	_	_
15	switching	switching	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	transcription	transcription	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	immunoglobulin	immunoglobulin	NN	NN	_	21	compound	_	_
21	heavy-chain	heavy-chain	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	17	nmod	_	_
23	at	at	IN	IN	_	25	case	_	_
24	late	late	JJ	JJ	_	25	amod	_	_
25	stages	stage	NNS	NNS	_	17	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	B-cell	b-cell	NN	NN	_	28	compound	_	_
28	differentiation	differentiation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	PEBP2	pebp2	NN	NN	_	4	compound	_	_
3	alpha/AML-1-related	alpha/aml-1-related	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	5	nsubj	_	_
5	increases	increase	VBZ	VBZ	_	0	root	_	_
6	osteocalcin	osteocalcin	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	through	through	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	binding	binding	NN	NN	_	5	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	osteoblast-specific	osteoblast-specific	JJ	JJ	_	16	amod	_	_
15	cis-acting	cis-acting	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	osteoblast-specific	osteoblast-specific	JJ	JJ	_	5	amod	_	_
4	cis-acting	cis-acting	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	trans-acting	trans-acting	JJ	JJ	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	5	conj	_	_
9	,	,	,	,	_	2	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	initiated	initiate	VBD	VBD	_	2	parataxis	_	_
12	an	a	DT	DT	_	13	det	_	_
13	analysis	analysis	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	promoter	promoter	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	mouse	mouse	NN	NN	_	21	compound	_	_
20	osteocalcin	osteocalcin	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	an	a	DT	DT	_	25	det	_	_
24	osteoblast-specific	osteoblast-specific	JJ	JJ	_	25	amod	_	_
25	gene	gene	NN	NN	_	21	appos	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	promoter	promoter	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	osteoblast-specific	osteoblast-specific	JJ	JJ	_	10	amod	_	_
9	cis-acting	cis-acting	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	6	dobj	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	Ducy	Ducy	NNP	NNP	_	14	compound	_	_
13	,	,	,	,	_	14	punct	_	_
14	P.	P.	NNP	NNP	_	6	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Karsenty	Karsenty	NNP	NNP	_	18	compound	_	_
17	,	,	,	,	_	18	punct	_	_
18	G.	G.	NNP	NNP	_	14	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	1995	1995	CD	CD	_	14	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	Mol.Cell.Biol.15	Mol.Cell.Biol.15	NNP	NNP	_	14	dep	_	_
23	,	,	,	,	_	14	punct	_	_
24	1858-1869	1858-1869	CD	CD	_	14	amod	_	_
25	)	)	-RRB-	-RRB-	_	14	punct	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	one	one	CD	CD	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	elements	element	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	OSE2	ose2	NN	NN	_	4	appos	_	_
10	,	,	,	,	_	2	punct	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	identical	identical	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	PEBP2	pebp2	NN	NN	_	22	compound	_	_
20	alpha/AML-1	alpha/aml-1	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	the	the	DT	DT	_	26	det	_	_
25	mammalian	mammalian	JJ	JJ	_	26	amod	_	_
26	homologues	homologue	NNS	NNS	_	22	appos	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	Drosophila	drosophila	FW	FW	_	31	compound	_	_
30	Runt	runt	NN	NN	_	31	compound	_	_
31	protein	protein	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	using	use	VBG	VBG	_	3	xcomp	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	recombinant	recombinant	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	a	a	DT	DT	_	15	det	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	antiserum	antiserum	NN	NN	_	7	conj	_	_
16	against	against	IN	IN	_	18	case	_	_
17	AML-1	aml-1	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	DNA-binding	dna-binding	JJ	JJ	_	21	amod	_	_
21	assays	assay	NNS	NNS	_	5	nmod	_	_
22	,	,	,	,	_	3	punct	_	_
23	that	that	IN	IN	_	32	mark	_	_
24	one	one	CD	CD	_	25	nummod	_	_
25	member	member	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	family	family	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	AML-1B	aml-1b	NN	NN	_	25	appos	_	_
31	,	,	,	,	_	25	punct	_	_
32	binds	bind	VBZ	VBZ	_	3	ccomp	_	_
33	specifically	specifically	RB	RB	_	32	advmod	_	_
34	to	to	TO	TO	_	35	case	_	_
35	OSE2	ose2	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	is	be	VBZ	VBZ	_	39	cop	_	_
38	immunologically	immunologically	RB	RB	_	39	advmod	_	_
39	related	related	JJ	JJ	_	32	conj	_	_
40	to	to	TO	TO	_	41	case	_	_
41	OSF2	osf2	NN	NN	_	39	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	the	the	DT	DT	_	44	det	_	_
44	factor	factor	NN	NN	_	41	appos	_	_
45	present	present	JJ	JJ	_	44	amod	_	_
46	in	in	IN	IN	_	49	case	_	_
47	osteoblast	osteoblast	NN	NN	_	49	compound	_	_
48	nuclear	nuclear	JJ	JJ	_	49	amod	_	_
49	extracts	extract	NNS	NNS	_	45	nmod	_	_
50	that	that	WDT	WDT	_	51	nsubj	_	_
51	binds	bind	VBZ	VBZ	_	44	acl:relcl	_	_
52	to	to	TO	TO	_	53	case	_	_
53	OSE2	ose2	NN	NN	_	51	nmod	_	_
54	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	4	case	_	_
2	DNA	dna	NN	NN	_	4	compound	_	_
3	cotransfection	cotransfection	NN	NN	_	4	compound	_	_
4	experiments	experiment	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	AML-1B	aml-1b	NN	NN	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	increase	increase	VB	VB	_	8	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	short	short	JJ	JJ	_	19	amod	_	_
18	osteocalcin	osteocalcin	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	14	nmod	_	_
20	through	through	IN	IN	_	22	case	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	binding	binding	NN	NN	_	12	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	OSE2	ose2	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Lastly	lastly	RB	RB	_	38	advmod	_	_
2	,	,	,	,	_	38	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	different	different	JJ	JJ	_	5	amod	_	_
5	mobilities	mobility	NNS	NNS	_	38	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	osteoblast	osteoblast	NN	NN	_	10	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
9	extract-DNA	extract-dna	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	5	nmod	_	_
11	compared	compare	VBN	VBN	_	16	case	_	_
12	with	with	IN	IN	_	16	case	_	_
13	T-cell	t-cell	NN	NN	_	16	compound	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	extract-DNA	extract-dna	JJ	JJ	_	16	amod	_	_
16	complexes	complex	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	along	along	IN	IN	_	21	case	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	inability	inability	NN	NN	_	38	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	OSF2	osf2	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	upregulated	upregulate	VBN	VBN	_	21	acl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	retinoic	retinoic	JJ	JJ	_	29	amod	_	_
29	acid	acid	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	38	punct	_	_
31	unlike	unlike	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	other	other	JJ	JJ	_	36	amod	_	_
34	PEBP2	pebp2	NN	NN	_	36	compound	_	_
35	alpha	alpha	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	38	nmod	_	_
37	,	,	,	,	_	38	punct	_	_
38	suggest	suggest	VBP	VBP	_	0	root	_	_
39	that	that	IN	IN	_	44	mark	_	_
40	OSF2	osf2	NN	NN	_	44	nsubj	_	_
41	is	be	VBZ	VBZ	_	44	cop	_	_
42	a	a	DT	DT	_	44	det	_	_
43	new	new	JJ	JJ	_	44	amod	_	_
44	member	member	NN	NN	_	38	ccomp	_	_
45	of	of	IN	IN	_	47	case	_	_
46	this	this	DT	DT	_	47	det	_	_
47	family	family	NN	NN	_	44	nmod	_	_
48	of	of	IN	IN	_	50	case	_	_
49	transcription	transcription	NN	NN	_	50	compound	_	_
50	factors	factor	NNS	NNS	_	47	nmod	_	_
51	.	.	.	.	_	38	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	5	nsubj	_	_
5	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	AML-1B	aml-1b	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	increase	increase	VB	VB	_	5	ccomp	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	osteoblast-specific	osteoblast-specific	JJ	JJ	_	15	amod	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	through	through	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	binding	binding	NN	NN	_	9	nmod	_	_
19	to	to	TO	TO	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	osteoblast-specific	osteoblast-specific	JJ	JJ	_	23	amod	_	_
22	cis-acting	cis-acting	JJ	JJ	_	23	amod	_	_
23	element	element	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	5	cc	_	_
25	presents	present	VBZ	VBZ	_	5	conj	_	_
26	evidence	evidence	NN	NN	_	25	dobj	_	_
27	that	that	IN	IN	_	31	mark	_	_
28	OSF2	osf2	NN	NN	_	31	nsubj	_	_
29	is	be	VBZ	VBZ	_	31	cop	_	_
30	a	a	DT	DT	_	31	det	_	_
31	member	member	NN	NN	_	26	ccomp	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	PEBP2	pebp2	NN	NN	_	36	compound	_	_
35	alpha/AML-1	alpha/aml-1	NN	NN	_	36	compound	_	_
36	family	family	NN	NN	_	31	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factors	factor	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	elevated	elevate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	zinc	zinc	NN	NN	_	11	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	trace	trace	NN	NN	_	18	compound	_	_
17	element	element	NN	NN	_	18	compound	_	_
18	preparation	preparation	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	trace	trace	NN	NN	_	4	compound	_	_
3	element	element	NN	NN	_	4	compound	_	_
4	preparation	preparation	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	Beres	beres	NN	NN	_	8	compound	_	_
7	Drops	drops	NN	NN	_	8	compound	_	_
8	Plus	plus	NN	NN	_	4	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	BDP	bdp	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	8	punct	_	_
12	elevates	elevate	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	gcR	gcr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	23	case	_	_
22	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
24	isolated	isolate	VBN	VBN	_	23	acl	_	_
25	both	both	CC	CC	_	29	dep	_	_
26	from	from	IN	IN	_	29	case	_	_
27	healthy	healthy	JJ	JJ	_	29	amod	_	_
28	blood	blood	NN	NN	_	29	compound	_	_
29	donors	donor	NNS	NNS	_	24	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	rheumatoid	rheumatoid	JJ	JJ	_	33	amod	_	_
32	arthritis	arthritis	NN	NN	_	33	compound	_	_
33	patients	patient	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	enhancement	enhancement	NN	NN	_	6	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	BDP	bdp	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	either	either	CC	CC	_	10	cc:preconj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	constitutive	constitutive	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	gcRs	gcr	NNS	NNS	_	10	nmod	_	_
13	or	or	CC	CC	_	10	cc	_	_
14	in	in	IN	IN	_	15	case	_	_
15	experiments	experiment	NNS	NNS	_	10	conj	_	_
16	when	when	WRB	WRB	_	20	advmod	_	_
17	the	the	DT	DT	_	18	det	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	stimulated	stimulate	VBN	VBN	_	6	advcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	interleukin	interleukin	NN	NN	_	24	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	IL	il	NN	NN	_	20	nmod	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	-6	-6	CD	CD	_	24	nummod	_	_
27	.	.	.	.	_	6	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	BDP	bdp	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	IL-1	il-1	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	tumour	tumour	NN	NN	_	14	compound	_	_
12	necrosis	necrosis	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	20	compound	_	_
15	(	(	-LRB-	-LRB-	_	20	punct	_	_
16	TNF	tnf	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	20	compound	_	_
18	)	)	-RRB-	-RRB-	_	20	punct	_	_
19	-induced	-induced	JJ	JJ	_	20	amod	_	_
20	changes	change	NNS	NNS	_	9	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	gcRs	gcr	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BDP	bdp	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	greatly	greatly	RB	RB	_	7	advmod	_	_
7	dependent	dependent	JJ	JJ	_	0	root	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Zn++	zn++	NN	NN	_	13	compound	_	_
13	ions	ion	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	preparation	preparation	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	since	since	IN	IN	_	23	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	augmenting	augment	VBG	VBG	_	21	amod	_	_
21	effect	effect	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	abolished	abolish	VBN	VBN	_	7	advcl	_	_
24	if	if	IN	IN	_	28	mark	_	_
25	BDP	bdp	NN	NN	_	28	nsubj	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	contain	contain	VB	VB	_	23	advcl	_	_
29	zinc	zinc	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	7	punct	_	_

1	Polymorphic	polymorphic	JJ	JJ	_	2	amod	_	_
2	nucleotides	nucleotide	NNS	NNS	_	0	root	_	_
3	within	within	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	2	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	mediate	mediate	VBP	VBP	_	2	acl:relcl	_	_
10	overexpression	overexpression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Atopy	atopy	NN	NN	_	20	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	predisposes	predispose	VBZ	VBZ	_	1	acl:relcl	_	_
5	individuals	individual	NNS	NNS	_	4	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	develop	develop	VB	VB	_	4	xcomp	_	_
8	asthma	asthma	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	severe	severe	JJ	JJ	_	11	amod	_	_
11	systemic	systemic	JJ	JJ	_	12	amod	_	_
12	anaphylaxis	anaphylaxis	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	atopic	atopic	JJ	JJ	_	16	amod	_	_
16	dermatitis	dermatitis	NN	NN	_	8	conj	_	_
17	,	,	,	,	_	1	punct	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	usually	usually	RB	RB	_	20	advmod	_	_
20	associated	associate	VBN	VBN	_	0	root	_	_
21	with	with	IN	IN	_	27	case	_	_
22	dramatically	dramatically	RB	RB	_	23	advmod	_	_
23	elevated	elevated	JJ	JJ	_	27	amod	_	_
24	total	total	JJ	JJ	_	27	amod	_	_
25	serum	serum	NN	NN	_	27	compound	_	_
26	IgE	ige	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	20	nmod	_	_
28	and	and	CC	CC	_	20	cc	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	thought	think	VBN	VBN	_	20	conj	_	_
31	to	to	TO	TO	_	33	mark	_	_
32	be	be	VB	VB	_	33	auxpass	_	_
33	controlled	control	VBN	VBN	_	30	xcomp	_	_
34	by	by	IN	IN	_	38	case	_	_
35	a	a	DT	DT	_	38	det	_	_
36	major	major	JJ	JJ	_	38	amod	_	_
37	susceptibility	susceptibility	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	33	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	multiple	multiple	JJ	JJ	_	41	amod	_	_
41	minor	minor	JJ	JJ	_	43	amod	_	_
42	susceptibility	susceptibility	NN	NN	_	43	compound	_	_
43	genes	gene	NNS	NNS	_	38	conj	_	_
44	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	recent	recent	JJ	JJ	_	4	amod	_	_
3	sib-pair	sib-pair	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	tight	tight	JJ	JJ	_	8	amod	_	_
8	linkage	linkage	NN	NN	_	5	dobj	_	_
9	between	between	IN	IN	_	10	case	_	_
10	markers	marker	NNS	NNS	_	8	nmod	_	_
11	on	on	IN	IN	_	12	case	_	_
12	5q31.1	5q31.1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	a	a	DT	DT	_	17	det	_	_
15	major	major	JJ	JJ	_	17	amod	_	_
16	susceptibility	susceptibility	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	10	conj	_	_
18	controlling	control	VBG	VBG	_	17	acl	_	_
19	total	total	JJ	JJ	_	22	amod	_	_
20	serum	serum	NN	NN	_	22	compound	_	_
21	IgE	ige	NN	NN	_	22	compound	_	_
22	levels	level	NNS	NNS	_	18	dobj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Due	due	IN	IN	_	4	case	_	_
2	to	to	TO	TO	_	4	case	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	location	location	NN	NN	_	25	nmod	_	_
5	within	within	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	cluster	cluster	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	biologic	biologic	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	4	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	Ig	ig	NN	NN	_	15	compound	_	_
14	class	class	NN	NN	_	15	compound	_	_
15	switching	switching	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Th2	th2	NN	NN	_	18	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	25	punct	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-4	il-4	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	25	nsubj	_	_
24	has	have	VBZ	VBZ	_	25	aux	_	_
25	emerged	emerge	VBN	VBN	_	0	root	_	_
26	as	as	IN	IN	_	29	case	_	_
27	one	one	CD	CD	_	29	nummod	_	_
28	major	major	JJ	JJ	_	29	amod	_	_
29	candidate	candidate	NN	NN	_	25	nmod	_	_
30	for	for	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	atopy	atopy	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	one	one	CD	CD	_	3	nummod	_	_
3	model	model	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	polymorphisms	polymorphism	NNS	NNS	_	11	nsubj	_	_
6	within	within	IN	IN	_	9	case	_	_
7	IL-4	il-4	NN	NN	_	9	compound	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	5	nmod	_	_
10	might	might	MD	MD	_	11	aux	_	_
11	result	result	VB	VB	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	overexpression	overexpression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	gene	gene	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	amplifying	amplify	VBG	VBG	_	11	advcl	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	18	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	class	class	NN	NN	_	24	compound	_	_
24	switching	switching	NN	NN	_	21	conj	_	_
25	to	to	TO	TO	_	26	case	_	_
26	IgE	ige	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	support	support	NN	NN	_	8	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	report	report	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	IL-4	il-4	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	14	nsubj	_	_
14	exists	exist	VBZ	VBZ	_	8	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	allelic	allelic	JJ	JJ	_	18	amod	_	_
18	forms	form	NNS	NNS	_	14	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	exhibit	exhibit	VBP	VBP	_	18	acl:relcl	_	_
21	distinct	distinct	JJ	JJ	_	23	amod	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activities	activity	NNS	NNS	_	20	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	IL-4-positive	il-4-positive	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	particular	particular	JJ	JJ	_	3	amod	_	_
3	allele	allele	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	9	det	_	_
6	unusually	unusually	RB	RB	_	7	advmod	_	_
7	high	high	JJ	JJ	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	4	dobj	_	_
10	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	nucleotide	nucleotide	JJ	JJ	_	3	amod	_	_
3	substitution	substitution	NN	NN	_	21	nsubj	_	_
4	within	within	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	recently	recently	RB	RB	_	7	advmod	_	_
7	described	describe	VBN	VBN	_	9	amod	_	_
8	OAP40	oap40	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	3	nmod	_	_
10	located	located	JJ	JJ	_	9	amod	_	_
11	just	just	RB	RB	_	12	advmod	_	_
12	upstream	upstream	RB	RB	_	10	advmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	an	a	DT	DT	_	16	det	_	_
15	NF-AT	nf-at	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	P	p	NN	NN	_	19	compound	_	_
19	sequence	sequence	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	appears	appear	VBZ	VBZ	_	0	root	_	_
22	to	to	TO	TO	_	25	mark	_	_
23	be	be	VB	VB	_	25	cop	_	_
24	largely	largely	RB	RB	_	25	advmod	_	_
25	responsible	responsible	JJ	JJ	_	21	xcomp	_	_
26	for	for	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	increased	increase	VBN	VBN	_	30	amod	_	_
29	promotor	promotor	NN	NN	_	30	compound	_	_
30	strength	strength	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	this	this	DT	DT	_	35	det	_	_
33	particular	particular	JJ	JJ	_	34	amod	_	_
34	allelic	allelic	JJ	JJ	_	35	amod	_	_
35	form	form	NN	NN	_	30	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	IL-4	il-4	NN	NN	_	39	compound	_	_
39	promoter	promoter	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	EMSAs	emsa	NNS	NNS	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	substitution	substitution	NN	NN	_	6	nsubj	_	_
6	results	result	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	enhanced	enhance	VBN	VBN	_	11	amod	_	_
11	affinity	affinity	NN	NN	_	6	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	sequence-specific	sequence-specific	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	11	nmod	_	_
15	exhibiting	exhibit	VBG	VBG	_	14	acl	_	_
16	an	a	DT	DT	_	18	det	_	_
17	AP-1	ap-1	NN	NN	_	18	compound	_	_
18	specificity	specificity	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	allelic	allelic	JJ	JJ	_	5	amod	_	_
5	nucleotides	nucleotide	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	results	result	VBZ	VBZ	_	5	acl:relcl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	overexpression	overexpression	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IL-4	il-4	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	provides	provide	VBZ	VBZ	_	0	root	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	targets	target	NNS	NNS	_	16	dobj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	comprehensive	comprehensive	JJ	JJ	_	22	amod	_	_
22	screening	screening	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	atopic	atopic	JJ	JJ	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	nonatopic	nonatopic	JJ	JJ	_	24	conj	_	_
27	individuals	individual	NNS	NNS	_	24	dep	_	_
28	and	and	CC	CC	_	16	cc	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	provide	provide	VB	VB	_	16	conj	_	_
31	a	a	DT	DT	_	32	det	_	_
32	clue	clue	NN	NN	_	30	dobj	_	_
33	for	for	IN	IN	_	35	case	_	_
34	genetic	genetic	JJ	JJ	_	35	amod	_	_
35	predisposition	predisposition	NN	NN	_	32	nmod	_	_
36	for	for	IN	IN	_	37	case	_	_
37	atopy	atopy	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	16	punct	_	_

1	NF-M	nf-m	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	chicken	chicken	NN	NN	_	5	compound	_	_
4	C/EBP	c/ebp	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	1	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	eosinophilic	eosinophilic	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	apoptosis	apoptosis	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	17	amod	_	_
15	progenitor	progenitor	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	CAAT/enhancer	caat/enhancer	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	C/EBPs	c/ebps	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activators	activator	NNS	NNS	_	0	root	_	_
10	implicated	implicate	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	differentiation	differentiation	NN	NN	_	14	compound	_	_
14	processes	process	NNS	NNS	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	various	various	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lineages	lineage	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	earlier	earlier	RBR	RBR	_	3	advmod	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	NF-M	nf-m	NN	NN	_	17	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	chicken	chicken	NN	NN	_	10	compound	_	_
10	homolog	homolog	NN	NN	_	6	appos	_	_
11	of	of	IN	IN	_	13	case	_	_
12	C/EBP	c/ebp	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	specifically	specifically	RB	RB	_	17	advmod	_	_
17	expressed	express	VBN	VBN	_	3	ccomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	myelomonocytic	myelomonocytic	JJ	JJ	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	eosinophilic	eosinophilic	JJ	JJ	_	19	conj	_	_
22	cells	cell	NNS	NNS	_	19	dep	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	hematopoietic	hematopoietic	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NF-M	nf-m	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	hematopoietic	hematopoietic	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lineage	lineage	NN	NN	_	11	compound	_	_
11	commitment	commitment	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	constructed	construct	VBD	VBD	_	2	parataxis	_	_
15	a	a	DT	DT	_	17	det	_	_
16	conditional	conditional	JJ	JJ	_	17	amod	_	_
17	form	form	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	protein	protein	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	fusing	fuse	VBG	VBG	_	14	advcl	_	_
23	it	it	PRP	PRP	_	22	dobj	_	_
24	to	to	TO	TO	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	hormone	hormone	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	domain	domain	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	human	human	JJ	JJ	_	33	amod	_	_
32	estrogen	estrogen	NN	NN	_	33	compound	_	_
33	receptor	receptor	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	construct	construct	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	stably	stably	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	multipotent	multipotent	JJ	JJ	_	11	amod	_	_
9	progenitor	progenitor	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	5	nmod	_	_
12	transformed	transform	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	Myb-Ets	myb-ets	NN	NN	_	16	compound	_	_
16	oncoprotein	oncoprotein	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	both	both	CC	CC	_	8	cc:preconj	_	_
6	NF-M-dependent	nf-m-dependent	JJ	JJ	_	8	amod	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	14	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	resident	resident	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	conj	_	_
12	could	could	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	activated	activate	VBN	VBN	_	2	ccomp	_	_
15	by	by	IN	IN	_	16	case	_	_
16	addition	addition	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	beta-estradiol	beta-estradiol	NN	NN	_	16	nmod	_	_
19	to	to	TO	TO	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	NF-M-estrogen	nf-m-estrogen	NN	NN	_	24	compound	_	_
22	receptor	receptor	NN	NN	_	24	compound	_	_
23	expressing	express	VBG	VBG	_	24	amod	_	_
24	progenitors	progenitor	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	At	at	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	same	same	JJ	JJ	_	4	amod	_	_
4	time	time	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	observed	observe	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	down-regulation	down-regulation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	progenitor-specific	progenitor-specific	JJ	JJ	_	13	amod	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	markers	marker	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	up-regulation	up-regulation	NN	NN	_	9	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	differentiation	differentiation	NN	NN	_	19	compound	_	_
19	markers	marker	NNS	NNS	_	16	nmod	_	_
20	restricted	restricted	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	eosinophil	eosinophil	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
26	lineages	lineage	NNS	NNS	_	23	conj	_	_
27	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	onset	onset	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	differentiation	differentiation	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	death	death	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	16	case	_	_
14	typical	typical	JJ	JJ	_	16	amod	_	_
15	apoptotic	apoptotic	JJ	JJ	_	14	dep	_	_
16	features	feature	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	NF-M	nf-m	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	commitment	commitment	NN	NN	_	6	nmod	_	_
12	along	along	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	eosinophil	eosinophil	NN	NN	_	15	compound	_	_
15	lineage	lineage	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	induction	induction	NN	NN	_	11	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Immunophenotype	immunophenotype	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	intraductal	intraductal	JJ	JJ	_	4	amod	_	_
4	carcinoma	carcinoma	NN	NN	_	1	nmod	_	_
5	.	.	.	.	_	1	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	--	--	:	:	_	1	punct	_	_
3	Mammography	mammography	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	breast-conserving	breast-conserving	JJ	JJ	_	6	amod	_	_
6	therapy	therapy	NN	NN	_	3	conj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	focused	focus	VBN	VBN	_	1	dep	_	_
9	attention	attention	NN	NN	_	8	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	classification	classification	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	intraductal	intraductal	JJ	JJ	_	15	amod	_	_
15	carcinoma	carcinoma	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IDC	idc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	emphasized	emphasize	VBN	VBN	_	8	conj	_	_
21	the	the	DT	DT	_	23	det	_	_
22	prognostic	prognostic	JJ	JJ	_	23	amod	_	_
23	importance	importance	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	comedo	comedo	NN	NN	_	23	nmod	_	_
26	versus	versus	CC	CC	_	25	cc	_	_
27	noncomedo	noncomedo	JJ	JJ	_	25	conj	_	_
28	variants	variant	NNS	NNS	_	25	dep	_	_
29	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	histochemical	histochemical	JJ	JJ	_	4	amod	_	_
4	markers	marker	NNS	NNS	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	define	define	VB	VB	_	2	advcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	immunophenotype	immunophenotype	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	43	43	CD	CD	_	11	nummod	_	_
11	IDCs	idc	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	respect	respect	NN	NN	_	6	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	comedo	comedo	NN	NN	_	13	nmod	_	_
16	versus	versus	CC	CC	_	15	cc	_	_
17	noncomedo	noncomedo	JJ	JJ	_	15	conj	_	_
18	status	status	NN	NN	_	15	dep	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	patterns	pattern	NNS	NNS	_	15	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	angiogenesis	angiogenesis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	--	--	:	:	_	1	punct	_	_
3	Reactions	reaction	NNS	NNS	_	9	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	comedo	comedo	NN	NN	_	6	compound	_	_
6	carcinomas	carcinoma	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	9	cop	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	negative	negative	JJ	JJ	_	1	dep	_	_
10	for	for	IN	IN	_	12	case	_	_
11	estrogen	estrogen	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	progesterone	progesterone	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	positive	positive	JJ	JJ	_	9	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	p53	p53	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	HER-2/neu	her-2/neu	NN	NN	_	20	conj	_	_
23	more	more	RBR	RBR	_	24	advmod	_	_
24	often	often	RB	RB	_	9	advmod	_	_
25	than	than	IN	IN	_	28	mark	_	_
26	the	the	DT	DT	_	28	det	_	_
27	noncomedo	noncomedo	JJ	JJ	_	28	amod	_	_
28	variant	variant	NN	NN	_	24	advcl	_	_
29	.	.	.	.	_	1	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	seven	seven	CD	CD	_	3	nummod	_	_
3	IDCs	idc	NNS	NNS	_	9	nsubj	_	_
4	associated	associate	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	8	case	_	_
6	Paget	paget	NN	NN	_	8	nmod:poss	_	_
7	's	's	POS	POS	_	8	case	_	_
8	disease	disease	NN	NN	_	4	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	positive	positive	JJ	JJ	_	11	amod	_	_
11	reactions	reaction	NNS	NNS	_	9	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	HER-2/neu	her-2/neu	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Basement	basement	NN	NN	_	3	compound	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	immunoreactivity	immunoreactivity	NN	NN	_	11	nsubj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	type	type	NN	NN	_	7	compound	_	_
6	IV	iv	CD	CD	_	7	nummod	_	_
7	collagen	collagen	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	laminin	laminin	NN	NN	_	7	conj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	discontinuous	discontinuous	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	most	most	JJS	JJS	_	14	amod	_	_
14	examples	example	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IDC	idc	NN	NN	_	14	nmod	_	_
17	regardless	regardless	RB	RB	_	16	advmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	type	type	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	with	with	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	trend	trend	NN	NN	_	11	nmod	_	_
24	toward	toward	IN	IN	_	27	case	_	_
25	more	more	RBR	RBR	_	26	advmod	_	_
26	intense	intense	JJ	JJ	_	27	amod	_	_
27	staining	staining	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	comedo	comedo	NN	NN	_	27	nmod	_	_
30	than	than	IN	IN	_	33	case	_	_
31	in	in	IN	IN	_	33	case	_	_
32	noncomedo	noncomedo	JJ	JJ	_	33	amod	_	_
33	carcinomas	carcinoma	NNS	NNS	_	27	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	Periductal	periductal	JJ	JJ	_	2	amod	_	_
2	angiogenesis	angiogenesis	NN	NN	_	6	nsubj	_	_
3	was	be	VBD	VBD	_	6	cop	_	_
4	not	not	RB	RB	_	6	neg	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	related	related	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	type	type	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	IDC	idc	NN	NN	_	9	nmod	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	was	be	VBD	VBD	_	15	cop	_	_
14	more	more	RBR	RBR	_	15	advmod	_	_
15	pronounced	pronounced	JJ	JJ	_	6	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	comedo	comedo	NN	NN	_	18	compound	_	_
18	carcinomas	carcinoma	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	--	--	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	observations	observation	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	are	be	VBP	VBP	_	5	ccomp	_	_
9	immunophenotypic	immunophenotypic	JJ	JJ	_	10	amod	_	_
10	correlates	correlate	NNS	NNS	_	8	nsubj	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	current	current	JJ	JJ	_	15	amod	_	_
14	structural	structural	JJ	JJ	_	13	dep	_	_
15	classification	classification	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IDC	idc	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	immunophenotype	immunophenotype	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IDC	idc	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	helpful	helpful	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	subclassifying	subclassify	VBG	VBG	_	6	advcl	_	_
9	an	a	DT	DT	_	10	det	_	_
10	IDC	idc	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	could	could	MD	MD	_	13	aux	_	_
13	prove	prove	VB	VB	_	6	conj	_	_
14	useful	useful	JJ	JJ	_	13	xcomp	_	_
15	as	as	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	prognostic	prognostic	JJ	JJ	_	18	amod	_	_
18	indicator	indicator	NN	NN	_	14	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	local	local	JJ	JJ	_	21	amod	_	_
21	control	control	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	patients	patient	NNS	NNS	_	21	nmod	_	_
24	treated	treat	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	breast-conserving	breast-conserving	JJ	JJ	_	27	amod	_	_
27	therapy	therapy	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	anetholdithiolthione	anetholdithiolthione	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	7	amod	_	_
2	factor	factor	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	NF	nf	NN	NN	_	7	compound	_	_
5	)	)	-RRB-	-RRB-	_	7	punct	_	_
6	-kappa	-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	14	nsubj	_	_
8	is	be	VBZ	VBZ	_	14	cop	_	_
9	a	a	DT	DT	_	14	det	_	_
10	redox	redox	NN	NN	_	14	compound	_	_
11	sensitive	sensitive	JJ	JJ	_	14	amod	_	_
12	cytosolic	cytosolic	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Redox	redox	NN	NN	_	2	compound	_	_
2	regulation	regulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	implicated	implicate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	immuno-deficiency	immuno-deficiency	NN	NN	_	16	compound	_	_
16	virus	virus	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HIV	hiv	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	nmod	_	_
8	may	may	MD	MD	_	12	aux	_	_
9	be	be	VB	VB	_	12	cop	_	_
10	an	a	DT	DT	_	12	det	_	_
11	effective	effective	JJ	JJ	_	12	amod	_	_
12	strategy	strategy	NN	NN	_	0	root	_	_
13	for	for	IN	IN	_	17	case	_	_
14	acquired	acquire	VBN	VBN	_	17	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
16	syndrome	syndrome	NN	NN	_	17	compound	_	_
17	therapy	therapy	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Anetholdithiolthione	anetholdithiolthione	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	ADT	adt	NN	NN	_	1	dep	_	_
4	,	,	,	,	_	3	punct	_	_
5	5--LSB-p-methoxyphenyl-RSB--3H-1,2-dithiol-3-thione	5--lsb-p-methoxyphenyl-rsb--3h-1,2-dithiol-3-thione	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	3	punct	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	an	a	DT	DT	_	9	det	_	_
9	antioxidant	antioxidant	NN	NN	_	0	root	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	used	use	VBN	VBN	_	9	acl:relcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	protect	protect	VB	VB	_	13	xcomp	_	_
16	against	against	IN	IN	_	17	case	_	_
17	acetaminophen-	acetaminophen-	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	CCl4-induced	ccl4-induced	JJ	JJ	_	17	conj	_	_
20	hepatotoxicity	hepatotoxicity	NN	NN	_	17	dep	_	_
21	,	,	,	,	_	17	punct	_	_
22	lipid	lipid	NN	NN	_	23	compound	_	_
23	peroxidation	peroxidation	NN	NN	_	17	appos	_	_
24	,	,	,	,	_	17	punct	_	_
25	radiation	radiation	NN	NN	_	26	compound	_	_
26	injury	injury	NN	NN	_	17	appos	_	_
27	,	,	,	,	_	13	punct	_	_
28	and	and	CC	CC	_	13	cc	_	_
29	also	also	RB	RB	_	32	advmod	_	_
30	has	have	VBZ	VBZ	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	used	use	VBN	VBN	_	13	conj	_	_
33	clinically	clinically	RB	RB	_	32	advmod	_	_
34	as	as	IN	IN	_	37	case	_	_
35	an	a	DT	DT	_	37	det	_	_
36	anti-choleretic	anti-choleretic	JJ	JJ	_	37	amod	_	_
37	agent	agent	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	ADT	adt	NN	NN	_	9	compound	_	_
9	pretreatment	pretreatment	NN	NN	_	6	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	6	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	variety	variety	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	stimuli	stimulus	NNS	NNS	_	18	nmod	_	_
21	such	such	JJ	JJ	_	23	case	_	_
22	as	as	IN	IN	_	21	mwe	_	_
23	H2O2	h2o2	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	phorbol	phorbol	NN	NN	_	27	compound	_	_
26	myristate	myristate	NN	NN	_	27	compound	_	_
27	acetate	acetate	NN	NN	_	23	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	PMA	pma	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	or	or	CC	CC	_	23	cc	_	_
32	tumor	tumor	NN	NN	_	35	compound	_	_
33	necrosis	necrosis	NN	NN	_	35	compound	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	alpha	alpha	NN	NN	_	23	conj	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	TNF	tnf	NN	NN	_	38	compound	_	_
38	alpha	alpha	NN	NN	_	35	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	4	punct	_	_

1	PMA	pma	NN	NN	_	19	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	TNF	tnf	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	conj	_	_
5	induced	induced	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	1	dep	_	_
7	of	of	IN	IN	_	12	case	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	NF	nf	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	-kappa	-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	1	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	Jurkat	jurkat	NN	NN	_	16	compound	_	_
16	T-cells	t-cell	NNS	NNS	_	1	nmod	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	partially	partially	RB	RB	_	19	advmod	_	_
19	inhibited	inhibit	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	26	case	_	_
21	ADT	adt	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	0.1	0.1	CD	CD	_	24	nummod	_	_
24	mM	mm	NN	NN	_	26	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	pretreatment	pretreatment	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	ADT	adt	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	0.1	0.1	CD	CD	_	4	nummod	_	_
4	mM	mm	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	H2O2	h2o2	NN	NN	_	10	compound	_	_
9	induced	induced	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	peroxide	peroxide	NN	NN	_	21	compound	_	_
18	sensitive	sensitive	JJ	JJ	_	21	amod	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	Wurzburg	wurzburg	NN	NN	_	21	compound	_	_
21	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	ADT	adt	NN	NN	_	7	nsubj	_	_
4	treated	treated	JJ	JJ	_	3	amod	_	_
5	Wurzburg	wurzburg	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	dep	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	higher	higher	JJR	JJR	_	11	amod	_	_
10	glutathione	glutathione	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	7	dobj	_	_
12	as	as	IN	IN	_	13	mark	_	_
13	compared	compare	VBN	VBN	_	7	advcl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	untreated	untreated	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	H2O2	h2o2	NN	NN	_	4	compound	_	_
2	induced	induced	JJ	JJ	_	4	amod	_	_
3	lipid	lipid	NN	NN	_	4	compound	_	_
4	peroxidation	peroxidation	NN	NN	_	10	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Wurzburg	wurzburg	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	remarkably	remarkably	RB	RB	_	10	advmod	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	ADT	adt	NN	NN	_	13	compound	_	_
13	pretreatment	pretreatment	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	ADT	adt	NN	NN	_	8	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	pro-glutathione	pro-glutathione	NN	NN	_	5	compound	_	_
5	antioxidant	antioxidant	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	capable	capable	JJ	JJ	_	8	xcomp	_	_
12	of	of	IN	IN	_	13	mark	_	_
13	modulating	modulate	VBG	VBG	_	11	advcl	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	8	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	physical	physical	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	1	nmod	_	_
6	between	between	IN	IN	_	7	case	_	_
7	calcineurin	calcineurin	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
10	factor	factor	NN	NN	_	14	compound	_	_
11	of	of	IN	IN	_	14	amod	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NFATp	nfatp	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	calcium/calmodulin-dependent	calcium/calmodulin-dependent	JJ	JJ	_	8	amod	_	_
7	serine/threonine	serine/threonine	JJ	JJ	_	8	amod	_	_
8	phosphatase	phosphatase	NN	NN	_	12	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	calcineurin	calcineurin	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	8	punct	_	_
12	plays	play	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	pivotal	pivotal	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	transducing	transduce	VBG	VBG	_	12	advcl	_	_
18	membrane-associated	membrane-associated	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	17	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	nucleus	nucleus	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	One	one	CD	CD	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	putative	putative	JJ	JJ	_	5	amod	_	_
5	targets	target	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	calcineurin	calcineurin	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	13	cop	_	_
9	the	the	DT	DT	_	13	det	_	_
10	pre-existing	pre-existing	JJ	JJ	_	13	amod	_	_
11	,	,	,	,	_	13	punct	_	_
12	cytosolic	cytosolic	JJ	JJ	_	13	amod	_	_
13	component	component	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
17	factor	factor	NN	NN	_	21	compound	_	_
18	of	of	IN	IN	_	21	amod	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NFATp	nfatp	NN	NN	_	21	dep	_	_
24	;	;	:	:	_	23	punct	_	_
25	also	also	RB	RB	_	23	advmod	_	_
26	referred	refer	VBN	VBN	_	23	acl	_	_
27	to	to	TO	TO	_	26	nmod	_	_
28	as	as	IN	IN	_	29	case	_	_
29	NFAT1	nfat1	NN	NN	_	26	nmod	_	_
30	)	)	-RRB-	-RRB-	_	23	punct	_	_
31	,	,	,	,	_	21	punct	_	_
32	which	which	WDT	WDT	_	34	nsubj	_	_
33	is	be	VBZ	VBZ	_	34	cop	_	_
34	one	one	CD	CD	_	21	acl:relcl	_	_
35	of	of	IN	IN	_	38	case	_	_
36	several	several	JJ	JJ	_	38	amod	_	_
37	transcription	transcription	NN	NN	_	38	compound	_	_
38	factors	factor	NNS	NNS	_	34	nmod	_	_
39	required	require	VBN	VBN	_	38	acl	_	_
40	for	for	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	expression	expression	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	interleukin	interleukin	NN	NN	_	42	nmod	_	_
45	2	2	CD	CD	_	44	nummod	_	_
46	.	.	.	.	_	13	punct	_	_

1	Inhibition	inhibition	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	calcineurin	calcineurin	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	immunosuppressive	immunosuppressive	JJ	JJ	_	7	amod	_	_
7	drugs	drug	NNS	NNS	_	1	nmod	_	_
8	cyclosporin	cyclosporin	NN	NN	_	9	compound	_	_
9	A	a	NN	NN	_	7	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	FK506	fk506	NN	NN	_	9	conj	_	_
12	prevents	prevent	VBZ	VBZ	_	0	root	_	_
13	dephosphorylation	dephosphorylation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NFATp	nfatp	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	translocation	translocation	NN	NN	_	13	conj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	nucleus	nucleus	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	physical	physical	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	13	nsubjpass	_	_
6	between	between	IN	IN	_	7	case	_	_
7	calcineurin	calcineurin	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NFATp	nfatp	NN	NN	_	7	conj	_	_
10	has	have	VBZ	VBZ	_	13	aux	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	binding	binding	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFATp	nfatp	NN	NN	_	5	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	lysates	lysate	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	immobilized	immobilize	VBN	VBN	_	15	amod	_	_
15	calcineurin	calcineurin	NN	NN	_	5	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Stimulation	stimulation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	ionophore	ionophore	NN	NN	_	1	nmod	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	shift	shift	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	weight	weight	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	NFATp	nfatp	NN	NN	_	14	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	due	due	JJ	JJ	_	10	acl:relcl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	dephosphorylation	dephosphorylation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	dephosphorylation	dephosphorylation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	inhibited	inhibit	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	treatment	treatment	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	6	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	FK506	fk506	NN	NN	_	12	conj	_	_
15	prior	prior	JJ	JJ	_	6	amod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	stimulation	stimulation	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	note	note	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	both	both	CC	CC	_	6	cc:preconj	_	_
5	the	the	DT	DT	_	6	det	_	_
6	phosphorylated	phosphorylated	JJ	JJ	_	13	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	9	det	_	_
9	dephosphorylated	dephosphorylated	JJ	JJ	_	6	conj	_	_
10	form	form	NN	NN	_	6	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFATp	nfatp	NN	NN	_	6	nmod	_	_
13	bound	bind	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	calcineurin	calcineurin	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	binding	binding	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	DT	DT	_	7	det	_	_
7	forms	form	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NFATp	nfatp	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	calcineurin	calcineurin	NN	NN	_	4	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	inhibited	inhibit	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	pretreatment	pretreatment	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	calcineurin	calcineurin	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	complex	complex	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	FK506	fk506	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	ligand	ligand	NN	NN	_	26	compound	_	_
26	FKBP12	fkbp12	NN	NN	_	20	conj	_	_
27	.	.	.	.	_	13	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	6	nsubj	_	_
5	strongly	strongly	RB	RB	_	6	advmod	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	a	a	DT	DT	_	9	det	_	_
8	direct	direct	JJ	JJ	_	9	amod	_	_
9	interaction	interaction	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	calcineurin	calcineurin	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	NFATp	nfatp	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	interaction	interaction	NN	NN	_	20	nsubj	_	_
18	does	do	VBZ	VBZ	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	depend	depend	VB	VB	_	9	conj	_	_
21	upon	upon	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	phosphorylation	phosphorylation	NN	NN	_	24	compound	_	_
24	sites	site	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	NFATp	nfatp	NN	NN	_	24	nmod	_	_
27	affected	affect	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	29	case	_	_
29	activation	activation	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	E2F-1	e2f-1	NN	NN	_	2	nsubj	_	_
2	blocks	block	VBZ	VBZ	_	0	root	_	_
3	terminal	terminal	JJ	JJ	_	4	amod	_	_
4	differentiation	differentiation	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	causes	cause	VBZ	VBZ	_	2	conj	_	_
7	proliferation	proliferation	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	transgenic	transgenic	JJ	JJ	_	10	amod	_	_
10	megakaryocytes	megakaryocyte	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	5	nsubj	_	_
4	E2F-1	e2f-1	NN	NN	_	3	dep	_	_
5	plays	play	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	central	central	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	cycle	cycle	NN	NN	_	5	nmod	_	_
13	through	through	IN	IN	_	15	case	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	5	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	activate	activate	VB	VB	_	15	acl	_	_
18	genes	gene	NNS	NNS	_	17	dobj	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	division	division	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	E2F-1	e2f-1	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	regulated	regulate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	number	number	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	proteins	protein	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	including	include	VBG	VBG	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	retinoblastoma	retinoblastoma	NN	NN	_	16	compound	_	_
14	susceptibility	susceptibility	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	product	product	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	cyclin-dependent	cyclin-dependent	JJ	JJ	_	19	amod	_	_
19	kinases	kinase	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	inhibitors	inhibitor	NNS	NNS	_	16	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	proteins	protein	NNS	NNS	_	23	appos	_	_
26	that	that	WDT	WDT	_	29	nsubjpass	_	_
27	have	have	VBP	VBP	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	implicated	implicate	VBN	VBN	_	23	acl:relcl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	control	control	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	certain	certain	JJ	JJ	_	36	amod	_	_
35	developmental	developmental	JJ	JJ	_	36	amod	_	_
36	processes	process	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	E2F-1	e2f-1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	differentiation	differentiation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	assayed	assay	VBD	VBD	_	2	parataxis	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	megakaryocytes	megakaryocyte	NNS	NNS	_	14	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	form	form	VB	VB	_	14	acl	_	_
19	platelets	platelet	NNS	NNS	_	18	dobj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	an	a	DT	DT	_	25	det	_	_
22	in	in	FW	FW	_	25	amod	_	_
23	vivo	vivo	FW	FW	_	22	dep	_	_
24	transgenic	transgenic	JJ	JJ	_	25	amod	_	_
25	model	model	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	E2F-1	e2f-1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	megakaryocytes	megakaryocyte	NNS	NNS	_	2	nmod	_	_
5	blocked	block	VBD	VBD	_	0	root	_	_
6	differentiation	differentiation	NN	NN	_	5	dobj	_	_
7	during	during	IN	IN	_	8	case	_	_
8	maturation	maturation	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	resulting	result	VBG	VBG	_	5	advcl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	severe	severe	JJ	JJ	_	13	amod	_	_
13	thrombocytopenia	thrombocytopenia	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Ultrastructural	ultrastructural	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	megakaryocytes	megakaryocyte	NNS	NNS	_	2	nmod	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	abnormal	abnormal	JJ	JJ	_	7	amod	_	_
7	development	development	NN	NN	_	5	dobj	_	_
8	characterized	characterize	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	hyperdemarcation	hyperdemarcation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytoplasmic	cytoplasmic	JJ	JJ	_	13	amod	_	_
13	membranes	membrane	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	reduced	reduce	VBN	VBN	_	16	amod	_	_
16	numbers	number	NNS	NNS	_	10	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	granules	granule	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Administration	administration	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	megakaryocyte	megakaryocyte	NN	NN	_	4	compound	_	_
4	growth	growth	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	development	development	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	4	conj	_	_
8	or	or	CC	CC	_	4	cc	_	_
9	interleukin	interleukin	NN	NN	_	4	conj	_	_
10	6	6	CD	CD	_	9	nummod	_	_
11	could	could	MD	MD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	overcome	overcome	VB	VB	_	0	root	_	_
14	the	the	DT	DT	_	16	det	_	_
15	differentiation	differentiation	NN	NN	_	16	compound	_	_
16	block	block	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	13	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	E2F-1	e2f-1	NN	NN	_	4	nsubj	_	_
4	caused	cause	VBD	VBD	_	0	root	_	_
5	massive	massive	JJ	JJ	_	7	amod	_	_
6	megakaryocyte	megakaryocyte	NN	NN	_	7	compound	_	_
7	accumulation	accumulation	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	normal	normal	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	ectopic	ectopic	JJ	JJ	_	10	conj	_	_
13	sites	site	NNS	NNS	_	10	dep	_	_
14	,	,	,	,	_	7	punct	_	_
15	first	first	RB	RB	_	16	advmod	_	_
16	evident	evident	JJ	JJ	_	7	amod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	E15	e15	CD	CD	_	20	nummod	_	_
19	embryonic	embryonic	JJ	JJ	_	20	amod	_	_
20	liver	liver	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	significant	significant	JJ	JJ	_	4	amod	_	_
4	apoptosis	apoptosis	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	transgenic	transgenic	JJ	JJ	_	9	amod	_	_
9	megakaryocytes	megakaryocyte	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	E2F-1	e2f-1	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	prevent	prevent	VB	VB	_	3	ccomp	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	probably	probably	RB	RB	_	16	advmod	_	_
12	through	through	IN	IN	_	16	case	_	_
13	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	cycle-stimulatory	cycle-stimulatory	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	7	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Stat3	stat3	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Stat5	stat5	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	platelets	platelet	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	essential	essential	JJ	JJ	_	3	xcomp	_	_
7	for	for	IN	IN	_	8	case	_	_
8	megakaryocytopoiesis	megakaryocytopoiesis	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	thrombopoiesis	thrombopoiesis	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	3	punct	_	_

1	Recently	recently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	we	we	PRP	PRP	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	others	other	NNS	NNS	_	3	conj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	thrombopoietin	thrombopoietin	NN	NN	_	10	nsubj	_	_
10	induces	induce	VBZ	VBZ	_	7	ccomp	_	_
11	rapid	rapid	JJ	JJ	_	13	amod	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Jak2	jak2	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	15	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	platelets	platelet	NNS	NNS	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	BaF3	baf3	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	genetically	genetically	RB	RB	_	27	advmod	_	_
27	engineered	engineer	VBN	VBN	_	21	acl	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	express	express	VB	VB	_	27	xcomp	_	_
30	c-Mpl	c-mpl	NN	NN	_	29	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	a	a	DT	DT	_	33	det	_	_
33	receptor	receptor	NN	NN	_	30	appos	_	_
34	for	for	IN	IN	_	35	case	_	_
35	thrombopoietin	thrombopoietin	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Jak	jak	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	kinases	kinase	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	known	know	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	mediate	mediate	VB	VB	_	8	xcomp	_	_
11	some	some	DT	DT	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effects	effect	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	cytokines	cytokine	NNS	NNS	_	14	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	hematopoietic	hematopoietic	JJ	JJ	_	20	amod	_	_
19	growth	growth	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	16	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	recruitment	recruitment	NN	NN	_	10	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	phosphorylation	phosphorylation	NN	NN	_	22	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	variety	variety	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	39	case	_	_
30	Stat	stat	NN	NN	_	39	compound	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	signal	signal	JJ	JJ	_	33	amod	_	_
33	transducers	transducer	NNS	NNS	_	30	dep	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	activators	activator	NNS	NNS	_	37	compound	_	_
36	of	of	IN	IN	_	37	amod	_	_
37	transcription	transcription	NN	NN	_	33	conj	_	_
38	)	)	-RRB-	-RRB-	_	33	punct	_	_
39	proteins	protein	NNS	NNS	_	28	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	Hence	hence	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	investigated	investigate	VBN	VBN	_	0	root	_	_
6	whether	whether	IN	IN	_	10	mark	_	_
7	Stat	stat	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	10	nsubj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	present	present	JJ	JJ	_	5	advcl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	platelets	platelet	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	,	,	,	,	_	10	punct	_	_
15	if	if	IN	IN	_	16	mark	_	_
16	so	so	RB	RB	_	10	dep	_	_
17	,	,	,	,	_	10	punct	_	_
18	whether	whether	IN	IN	_	20	mark	_	_
19	they	they	PRP	PRP	_	20	nsubj	_	_
20	become	become	VBP	VBP	_	10	dep	_	_
21	tyrosine	tyrosine	NN	NN	_	20	xcomp	_	_
22	phosphorylated	phosphorylated	JJ	JJ	_	21	dep	_	_
23	in	in	IN	IN	_	24	case	_	_
24	response	response	NN	NN	_	21	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	thrombopoietin	thrombopoietin	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	immunologically	immunologically	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	Stat1	stat1	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	Stat2	stat2	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	Stat3	stat3	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	Stat5	stat5	NN	NN	_	4	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	platelet	platelet	NN	NN	_	15	compound	_	_
15	lysates	lysate	NNS	NNS	_	4	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Stat3	stat3	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Stat5	stat5	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Stat3	stat3	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Stat5	stat5	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	FDCP-2	fdcp-2	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	genetically	genetically	RB	RB	_	14	advmod	_	_
14	engineered	engineer	VBN	VBN	_	7	acl	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	constitutively	constitutively	RB	RB	_	17	advmod	_	_
17	express	express	VB	VB	_	14	xcomp	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	c-Mpl	c-mpl	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	Stat3	stat3	NN	NN	_	12	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Stat5	stat5	NN	NN	_	7	conj	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	5	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	transduction	transduction	NN	NN	_	12	nmod	_	_
16	after	after	IN	IN	_	18	case	_	_
17	ligand	ligand	NN	NN	_	18	compound	_	_
18	binding	binding	NN	NN	_	15	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	c-Mpl	c-mpl	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	12	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	this	this	DT	DT	_	24	det	_	_
24	event	event	NN	NN	_	26	nsubj	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	have	have	VB	VB	_	12	conj	_	_
27	a	a	DT	DT	_	28	det	_	_
28	role	role	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	megakaryopoiesis/thrombopoiesis	megakaryopoiesis/thrombopoiesis	JJ	JJ	_	26	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	possibly	possibly	RB	RB	_	36	advmod	_	_
33	a	a	DT	DT	_	36	det	_	_
34	mature	mature	JJ	JJ	_	36	amod	_	_
35	platelet	platelet	NN	NN	_	36	compound	_	_
36	function	function	NN	NN	_	30	conj	_	_
37	such	such	JJ	JJ	_	39	case	_	_
38	as	as	IN	IN	_	37	mwe	_	_
39	aggregation	aggregation	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	promoter	promoter	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	5'	5'	JJ	JJ	_	6	amod	_	_
5	flanking	flanking	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	2	conj	_	_
7	controlling	control	VBG	VBG	_	2	acl	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	B29	b29	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	product	product	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	B-cell-specific	b-cell-specific	JJ	JJ	_	7	amod	_	_
6	B29	b29	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	B29	b29	NN	NN	_	7	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	Ig	ig	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	9	appos	_	_
13	,	,	,	,	_	9	punct	_	_
14	CD79b	cd79b	NN	NN	_	9	appos	_	_
15	)	)	-RRB-	-RRB-	_	9	punct	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	essential	essential	JJ	JJ	_	0	root	_	_
18	for	for	IN	IN	_	21	case	_	_
19	Ig-mediated	ig-mediated	JJ	JJ	_	21	amod	_	_
20	B-cell	b-cell	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	17	nmod	_	_
22	via	via	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	B-cell	b-cell	NN	NN	_	27	compound	_	_
25	antigen	antigen	NN	NN	_	27	compound	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	complex	complex	NN	NN	_	17	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	BCR	bcr	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	on	on	IN	IN	_	32	case	_	_
32	human	human	JJ	JJ	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	murine	murine	JJ	JJ	_	32	conj	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	lymphocytes	lymphocyte	NNS	NNS	_	32	dep	_	_
37	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	pivotal	pivotal	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	analyzed	analyze	VBN	VBN	_	3	parataxis	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	genomic	genomic	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	13	dobj	_	_
19	upstream	upstream	RB	RB	_	18	advmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	B29	b29	NN	NN	_	19	nmod	_	_
23	ATG	atg	NN	NN	_	25	compound	_	_
24	start	start	VBP	VBP	_	25	dep	_	_
25	codon	codon	NN	NN	_	22	dep	_	_
26	for	for	IN	IN	_	29	case	_	_
27	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
28	control	control	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	13	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	B29	b29	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	nsubj	_	_
5	lacks	lack	VBZ	VBZ	_	0	root	_	_
6	either	either	CC	CC	_	8	cc:preconj	_	_
7	a	a	DT	DT	_	8	det	_	_
8	TATA	tata	NN	NN	_	5	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	11	det	_	_
11	CAAT	caat	NN	NN	_	8	conj	_	_
12	box	box	NN	NN	_	8	dep	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	transcription	transcription	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	initiated	initiate	VBN	VBN	_	5	conj	_	_
17	at	at	IN	IN	_	19	case	_	_
18	multiple	multiple	JJ	JJ	_	19	amod	_	_
19	sites	site	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	minimal	minimal	JJ	JJ	_	3	amod	_	_
3	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	B29	b29	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	contained	contain	VBN	VBN	_	0	root	_	_
11	within	within	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	193-bp	193-bp	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	10	nmod	_	_
15	5'	5'	JJ	JJ	_	14	amod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	these	these	DT	DT	_	20	det	_	_
18	multiple	multiple	JJ	JJ	_	20	amod	_	_
19	start	start	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	minimal	minimal	JJ	JJ	_	3	amod	_	_
3	promoter	promoter	NN	NN	_	4	nsubj	_	_
4	exhibits	exhibit	VBZ	VBZ	_	0	root	_	_
5	B-cell-specific	b-cell-specific	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	contains	contain	VBZ	VBZ	_	4	conj	_	_
9	SP1	sp1	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	ETS	ets	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	OCT	oct	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	IKAROS/LYF-1	ikaros/lyf-1	NN	NN	_	9	conj	_	_
17	transcription	transcription	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	motifs	motif	NNS	NNS	_	9	dep	_	_
20	.	.	.	.	_	4	punct	_	_

1	All	all	DT	DT	_	3	det:predet	_	_
2	these	these	DT	DT	_	3	det	_	_
3	motifs	motif	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	strikingly	strikingly	RB	RB	_	6	advmod	_	_
6	conserved	conserve	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	sequence	sequence	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	placement	placement	NN	NN	_	8	conj	_	_
11	relative	relative	JJ	JJ	_	8	amod	_	_
12	to	to	TO	TO	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	previously	previously	RB	RB	_	15	advmod	_	_
15	characterized	characterize	VBN	VBN	_	18	amod	_	_
16	murine	murine	JJ	JJ	_	18	amod	_	_
17	B29	b29	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Additional	additional	JJ	JJ	_	4	amod	_	_
2	upstream	upstream	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	segments	segment	NNS	NNS	_	6	nsubj	_	_
5	dramatically	dramatically	RB	RB	_	6	advmod	_	_
6	affected	affect	VBD	VBD	_	0	root	_	_
7	B29	b29	NN	NN	_	10	compound	_	_
8	minimal	minimal	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	newly	newly	RB	RB	_	3	advmod	_	_
3	identified	identify	VBN	VBN	_	4	amod	_	_
4	motif	motif	NN	NN	_	24	nsubj	_	_
5	called	call	VBN	VBN	_	4	dep	_	_
6	the	the	DT	DT	_	9	det	_	_
7	B29	b29	NN	NN	_	9	compound	_	_
8	conserved	conserve	VBN	VBN	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	5	xcomp	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	BCS	bcs	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	5	punct	_	_
14	found	find	VBN	VBN	_	5	dep	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	15	nmod	_	_
17	both	both	CC	CC	_	16	dep	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	murine	murine	JJ	JJ	_	18	conj	_	_
21	B29	b29	NN	NN	_	22	compound	_	_
22	promoters	promoter	NNS	NNS	_	16	conj	_	_
23	,	,	,	,	_	4	punct	_	_
24	appears	appear	VBZ	VBZ	_	0	root	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	stimulate	stimulate	VB	VB	_	24	xcomp	_	_
27	B29	b29	NN	NN	_	28	compound	_	_
28	transcription	transcription	NN	NN	_	26	dobj	_	_
29	through	through	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	novel	novel	JJ	JJ	_	32	amod	_	_
32	mechanism	mechanism	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	single	single	JJ	JJ	_	3	amod	_	_
3	BCS	bcs	NN	NN	_	4	nsubj	_	_
4	had	have	VBD	VBD	_	0	root	_	_
5	little	little	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	either	either	CC	CC	_	12	cc:preconj	_	_
8	on	on	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	minimal	minimal	JJ	JJ	_	12	amod	_	_
11	B29	b29	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	4	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	on	on	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Instead	instead	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	BCS	bcs	NN	NN	_	5	nsubj	_	_
5	stimulated	stimulate	VBD	VBD	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	counteracting	counteract	VBG	VBG	_	5	advcl	_	_
9	5'	5'	JJ	JJ	_	13	amod	_	_
10	negative	negative	JJ	JJ	_	13	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	sequences	sequence	NNS	NNS	_	8	dobj	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	block	block	VBP	VBP	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activity	activity	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	B29	b29	NN	NN	_	17	nmod	_	_
21	minimal	minimal	JJ	JJ	_	22	amod	_	_
22	promoter	promoter	NN	NN	_	20	dep	_	_
23	in	in	IN	IN	_	25	case	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	absence	absence	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	B29	b29	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	3	ccomp	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	complex	complex	JJ	JJ	_	13	amod	_	_
13	interplay	interplay	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	positive	positive	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	negative	negative	JJ	JJ	_	19	amod	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	elements	element	NNS	NNS	_	15	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	12	case	_	_
3	vitamin	vitamin	NN	NN	_	10	compound	_	_
4	D	d	NN	NN	_	10	compound	_	_
5	receptor-retinoid	receptor-retinoid	JJ	JJ	_	10	amod	_	_
6	X	x	NN	NN	_	10	compound	_	_
7	receptor-vitamin	receptor-vitamin	JJ	JJ	_	10	amod	_	_
8	D	d	NN	NN	_	10	compound	_	_
9	response	response	NN	NN	_	10	compound	_	_
10	element	element	NN	NN	_	12	compound	_	_
11	complex	complex	JJ	JJ	_	10	amod	_	_
12	formation	formation	NN	NN	_	1	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	1	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	vitamin	vitamin	NN	NN	_	22	compound	_	_
18	D-resistant	d-resistant	JJ	JJ	_	22	amod	_	_
19	New	new	NN	NN	_	22	compound	_	_
20	World	world	NN	NN	_	22	compound	_	_
21	primate	primate	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	Most	most	JJS	JJS	_	8	amod	_	_
2	New	new	NN	NN	_	4	compound	_	_
3	World	world	NN	NN	_	4	compound	_	_
4	primate	primate	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NWP	nwp	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	genera	genera	NN	NN	_	9	nsubj	_	_
9	evolved	evolve	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	require	require	VB	VB	_	9	xcomp	_	_
12	high	high	JJ	JJ	_	14	amod	_	_
13	circulating	circulating	JJ	JJ	_	14	amod	_	_
14	levels	level	NNS	NNS	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	steroid	steroid	NN	NN	_	17	compound	_	_
17	hormones	hormone	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	vitamin	vitamin	NN	NN	_	20	compound	_	_
20	D	d	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	32	mark	_	_
4	an	a	DT	DT	_	9	det	_	_
5	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
6	vitamin	vitamin	NN	NN	_	9	compound	_	_
7	D	d	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	32	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IDBP	idbp	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	present	present	JJ	JJ	_	9	amod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	nuclear	nuclear	JJ	JJ	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cytoplasmic	cytoplasmic	JJ	JJ	_	17	conj	_	_
20	fractions	fraction	NNS	NNS	_	17	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NWP	nwp	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	or	or	CC	CC	_	17	cc	_	_
26	another	another	DT	DT	_	29	det	_	_
27	protein	protein	NN	NN	_	29	compound	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	s	s	NNS	NNS	_	17	conj	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	may	may	MD	MD	_	32	aux	_	_
32	cause	cause	VB	VB	_	2	ccomp	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	contribute	contribute	VB	VB	_	32	conj	_	_
35	to	to	TO	TO	_	34	nmod	_	_
36	the	the	DT	DT	_	39	det	_	_
37	steroid	steroid	NN	NN	_	39	compound	_	_
38	hormone-resistant	hormone-resistant	JJ	JJ	_	39	amod	_	_
39	state	state	NN	NN	_	32	dobj	_	_
40	in	in	IN	IN	_	41	case	_	_
41	NWP	nwp	NN	NN	_	39	nmod	_	_
42	by	by	IN	IN	_	43	case	_	_
43	disruption	disruption	NN	NN	_	32	nmod	_	_
44	of	of	IN	IN	_	48	case	_	_
45	the	the	DT	DT	_	48	det	_	_
46	receptor	receptor	NN	NN	_	48	compound	_	_
47	dimerization	dimerization	NN	NN	_	48	compound	_	_
48	process	process	NN	NN	_	43	nmod	_	_
49	and/or	and/or	CC	CC	_	43	cc	_	_
50	by	by	IN	IN	_	51	case	_	_
51	interference	interference	NN	NN	_	43	conj	_	_
52	of	of	IN	IN	_	54	case	_	_
53	receptor	receptor	NN	NN	_	54	compound	_	_
54	complex	complex	NN	NN	_	51	nmod	_	_
55	binding	bind	VBG	VBG	_	54	acl	_	_
56	to	to	TO	TO	_	60	case	_	_
57	the	the	DT	DT	_	60	det	_	_
58	consensus	consensus	NN	NN	_	60	compound	_	_
59	response	response	NN	NN	_	60	compound	_	_
60	elements	element	NNS	NNS	_	55	nmod	_	_
61	present	present	JJ	JJ	_	60	amod	_	_
62	in	in	IN	IN	_	65	case	_	_
63	the	the	DT	DT	_	65	det	_	_
64	enhancer	enhancer	NN	NN	_	65	compound	_	_
65	regions	region	NNS	NNS	_	61	nmod	_	_
66	of	of	IN	IN	_	68	case	_	_
67	steroid-responsive	steroid-responsive	JJ	JJ	_	68	amod	_	_
68	genes	gene	NNS	NNS	_	65	nmod	_	_
69	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	employed	employ	VBD	VBD	_	0	root	_	_
3	electromobility	electromobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	2	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EMSA	emsa	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	screen	screen	VB	VB	_	2	advcl	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	presence	presence	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	proteins	protein	NNS	NNS	_	13	nmod	_	_
16	capable	capable	JJ	JJ	_	15	amod	_	_
17	of	of	IN	IN	_	18	mark	_	_
18	binding	bind	VBG	VBG	_	16	advcl	_	_
19	to	to	TO	TO	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	vitamin	vitamin	NN	NN	_	24	compound	_	_
22	D	d	NN	NN	_	24	compound	_	_
23	response	response	NN	NN	_	24	compound	_	_
24	element	element	NN	NN	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	VDRE	vdre	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	post-nuclear	post-nuclear	JJ	JJ	_	1	conj	_	_
4	extracts	extract	NNS	NNS	_	1	dep	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	prepared	prepare	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	11	case	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	6	nmod	_	_
12	known	know	VBN	VBN	_	11	acl	_	_
13	to	to	TO	TO	_	12	dep	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	representative	representative	JJ	JJ	_	13	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	vitamin	vitamin	NN	NN	_	15	nmod	_	_
19	D-resistant	d-resistant	JJ	JJ	_	18	amod	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	wild	wild	JJ	JJ	_	23	amod	_	_
22	type	type	NN	NN	_	23	compound	_	_
23	phenotypes	phenotype	NNS	NNS	_	18	conj	_	_
24	,	,	,	,	_	15	punct	_	_
25	respectively	respectively	RB	RB	_	15	advmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	extracts	extract	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	compared	compare	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
7	ability	ability	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	retard	retard	VB	VB	_	7	acl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	migration	migration	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	radiolabeled	radiolabele	VBN	VBN	_	17	amod	_	_
14	double	double	JJ	JJ	_	15	amod	_	_
15	stranded	stranded	JJ	JJ	_	13	dep	_	_
16	oligomers	oligomer	NNS	NNS	_	17	compound	_	_
17	representative	representative	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	VDREs	vdre	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	osteocalcin	osteocalcin	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	mouse	mouse	NN	NN	_	28	compound	_	_
28	osteopontin	osteopontin	NN	NN	_	24	conj	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	promoters	promoter	NNS	NNS	_	24	dep	_	_
31	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	specific	specific	JJ	JJ	_	5	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	retarded	retarded	JJ	JJ	_	2	dep	_	_
5	band	band	NN	NN	_	9	nsubjpass	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	VDR-RXR	vdr-rxr	NN	NN	_	6	dobj	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	identified	identify	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	13	advmod	_	_
11	wild	wild	JJ	JJ	_	13	amod	_	_
12	type	type	NN	NN	_	13	compound	_	_
13	cell	cell	NN	NN	_	9	advcl	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	13	cc	_	_
16	when	when	WRB	WRB	_	23	advmod	_	_
17	vitamin	vitamin	NN	NN	_	21	compound	_	_
18	D-resistant	d-resistant	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	extract	extract	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	used	use	VBN	VBN	_	13	conj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	reaction	reaction	NN	NN	_	23	nmod	_	_
28	with	with	IN	IN	_	30	case	_	_
29	either	either	DT	DT	_	30	det	_	_
30	probe	probe	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	vitamin	vitamin	NN	NN	_	8	compound	_	_
5	D-resistant	d-resistant	JJ	JJ	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	extract	extract	NN	NN	_	9	nsubj	_	_
9	contained	contain	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	s	s	NNS	NNS	_	9	dobj	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	bound	bind	VBN	VBN	_	13	acl:relcl	_	_
18	specifically	specifically	RB	RB	_	21	advmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	VDRE	vdre	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	capable	capable	JJ	JJ	_	17	conj	_	_
25	of	of	IN	IN	_	27	mark	_	_
26	completely	completely	RB	RB	_	27	advmod	_	_
27	inhibiting	inhibit	VBG	VBG	_	24	advcl	_	_
28	VDR-RXR-VDRE	vdr-rxr-vdre	JJ	JJ	_	29	amod	_	_
29	complex	complex	NN	NN	_	30	compound	_	_
30	formation	formation	NN	NN	_	27	dobj	_	_
31	;	;	:	:	_	9	punct	_	_
32	these	these	DT	DT	_	33	det	_	_
33	effects	effect	NNS	NNS	_	36	nsubjpass	_	_
34	were	be	VBD	VBD	_	36	auxpass	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	demonstrated	demonstrate	VBN	VBN	_	9	parataxis	_	_
37	with	with	IN	IN	_	39	case	_	_
38	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
39	extract	extract	NN	NN	_	36	nmod	_	_
40	from	from	IN	IN	_	45	case	_	_
41	the	the	DT	DT	_	45	det	_	_
42	wild	wild	JJ	JJ	_	45	amod	_	_
43	type	type	NN	NN	_	45	compound	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	line	line	NN	NN	_	39	nmod	_	_
46	or	or	CC	CC	_	39	cc	_	_
47	with	with	IN	IN	_	50	case	_	_
48	the	the	DT	DT	_	50	det	_	_
49	post-nuclear	post-nuclear	JJ	JJ	_	50	amod	_	_
50	extract	extract	NN	NN	_	39	conj	_	_
51	of	of	IN	IN	_	56	case	_	_
52	the	the	DT	DT	_	56	det	_	_
53	vitamin	vitamin	NN	NN	_	56	compound	_	_
54	D-resistant	d-resistant	JJ	JJ	_	56	amod	_	_
55	cell	cell	NN	NN	_	56	compound	_	_
56	line	line	NN	NN	_	50	nmod	_	_
57	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	29	mark	_	_
4	a	a	DT	DT	_	8	det	_	_
5	VDRE-binding	vdre-binding	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	29	nsubj	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	8	punct	_	_
11	distinct	distinct	JJ	JJ	_	8	amod	_	_
12	from	from	IN	IN	_	13	case	_	_
13	IDBP	idbp	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	present	present	JJ	JJ	_	11	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extract	extract	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	18	nmod	_	_
21	from	from	IN	IN	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	prototypical	prototypical	JJ	JJ	_	26	amod	_	_
24	vitamin	vitamin	NN	NN	_	26	compound	_	_
25	D-resistant	d-resistant	JJ	JJ	_	26	amod	_	_
26	NWP	nwp	NN	NN	_	20	nmod	_	_
27	,	,	,	,	_	8	punct	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	capable	capable	JJ	JJ	_	2	ccomp	_	_
30	of	of	IN	IN	_	31	mark	_	_
31	inhibiting	inhibit	VBG	VBG	_	29	advcl	_	_
32	normal	normal	JJ	JJ	_	34	amod	_	_
33	VDR-RXR	vdr-rxr	NN	NN	_	34	compound	_	_
34	heterodimer	heterodimer	NN	NN	_	31	dobj	_	_
35	binding	bind	VBG	VBG	_	34	acl	_	_
36	to	to	TO	TO	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	VDRE	vdre	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	damaging	damaging	NN	NN	_	6	compound	_	_
6	agents	agent	NNS	NNS	_	2	nmod	_	_
7	on	on	IN	IN	_	12	case	_	_
8	HIV	hiv	NN	NN	_	12	compound	_	_
9	long	long	JJ	JJ	_	12	amod	_	_
10	terminal	terminal	JJ	JJ	_	12	amod	_	_
11	repeat	repeat	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	12	conj	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	15	advmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Much	much	JJ	JJ	_	2	amod	_	_
2	attention	attention	NN	NN	_	5	nsubj	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	recently	recently	RB	RB	_	5	advmod	_	_
5	focused	focus	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	observation	observation	NN	NN	_	5	nmod	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	UV	uv	NN	NN	_	11	compound	_	_
11	light	light	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	activate	activate	VB	VB	_	8	ccomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	13	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	LTR	ltr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	immunodeficiency	immunodeficiency	NN	NN	_	25	compound	_	_
25	virus	virus	NN	NN	_	17	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	HIV	hiv	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	mechanism	mechanism	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	LTR	ltr	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	remains	remain	VBZ	VBZ	_	15	advcl	_	_
8	obscure	obscure	JJ	JJ	_	7	xcomp	_	_
9	,	,	,	,	_	15	punct	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	lines	line	NNS	NNS	_	15	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	investigation	investigation	NN	NN	_	11	nmod	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	suggested	suggest	VBN	VBN	_	0	root	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	it	it	PRP	PRP	_	20	nsubj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	a	a	DT	DT	_	20	det	_	_
20	result	result	NN	NN	_	15	ccomp	_	_
21	of	of	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
26	B	b	NN	NN	_	30	compound	_	_
27	transcription	transcription	NN	NN	_	30	compound	_	_
28	factor	factor	NN	NN	_	30	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	s	s	NNS	NNS	_	22	nmod	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	following	follow	VBG	VBG	_	34	case	_	_
33	signaling	signaling	NN	NN	_	34	compound	_	_
34	events	event	NNS	NNS	_	22	nmod	_	_
35	related	related	JJ	JJ	_	34	amod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	generalized	generalize	VBN	VBN	_	39	amod	_	_
38	DNA	dna	NN	NN	_	39	compound	_	_
39	damage	damage	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	present	present	VBP	VBP	_	0	root	_	_
7	data	datum	NNS	NNS	_	6	dobj	_	_
8	demonstrating	demonstrating	NN	NN	_	7	dep	_	_
9	that	that	IN	IN	_	17	mark	_	_
10	HIV	hiv	NN	NN	_	12	compound	_	_
11	LTR	ltr	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	17	nsubj	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	not	not	RB	RB	_	17	neg	_	_
15	a	a	DT	DT	_	17	det	_	_
16	general	general	JJ	JJ	_	17	amod	_	_
17	consequence	consequence	NN	NN	_	8	ccomp	_	_
18	of	of	IN	IN	_	21	case	_	_
19	cellular	cellular	JJ	JJ	_	21	amod	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	damage	damage	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	but	but	CC	CC	_	24	cc	_	_
24	rather	rather	RB	RB	_	17	cc	_	_
25	a	a	DT	DT	_	26	det	_	_
26	process	process	NN	NN	_	17	conj	_	_
27	unique	unique	JJ	JJ	_	26	amod	_	_
28	to	to	TO	TO	_	31	case	_	_
29	specific	specific	JJ	JJ	_	31	amod	_	_
30	genotoxic	genotoxic	JJ	JJ	_	31	amod	_	_
31	stimuli	stimulus	NNS	NNS	_	27	nmod	_	_
32	,	,	,	,	_	17	punct	_	_
33	and	and	CC	CC	_	17	cc	_	_
34	that	that	IN	IN	_	39	mark	_	_
35	it	it	PRP	PRP	_	39	nsubj	_	_
36	does	do	VBZ	VBZ	_	39	aux	_	_
37	not	not	RB	RB	_	38	dep	_	_
38	necessarily	necessarily	RB	RB	_	39	advmod	_	_
39	depend	depend	VB	VB	_	17	conj	_	_
40	on	on	IN	IN	_	41	case	_	_
41	activation	activation	NN	NN	_	39	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	NF-kappa	nf-kappa	NN	NN	_	44	compound	_	_
44	B	b	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	several	several	JJ	JJ	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	agents	agent	NNS	NNS	_	6	nmod	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	increase	increase	VB	VB	_	4	ccomp	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	replication	replication	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	accelerate	accelerate	VB	VB	_	12	conj	_	_
17	CD4-positive	cd4-positive	JJ	JJ	_	19	amod	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	cytotoxicity	cytotoxicity	NN	NN	_	16	dobj	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vitro	vitro	FW	FW	_	12	advmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	7	nsubj	_	_
3	,	,	,	,	_	7	punct	_	_
4	therefore	therefore	RB	RB	_	7	advmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	have	have	VB	VB	_	0	root	_	_
8	clinical	clinical	JJ	JJ	_	9	amod	_	_
9	significance	significance	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	AIDS	aids	NN	NN	_	12	compound	_	_
12	patients	patient	NNS	NNS	_	7	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	malignancies	malignancy	NNS	NNS	_	12	nmod	_	_
15	who	who	WP	WP	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	aux	_	_
17	undergoing	undergo	VBG	VBG	_	12	acl:relcl	_	_
18	radiotherapy	radiotherapy	NN	NN	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	chemotherapy	chemotherapy	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Fas	fas	NN	NN	_	2	compound	_	_
2	ligation	ligation	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	apoptosis	apoptosis	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Jun	jun	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	4	conj	_	_
9	independently	independently	RB	RB	_	3	advmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD45	cd45	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Lck	lck	NN	NN	_	11	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	through	through	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Fas/APO-1	fas/apo-1	JJ	JJ	_	5	amod	_	_
5	receptor	receptor	NN	NN	_	1	nmod	_	_
6	results	result	NNS	NNS	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	through	through	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	incompletely	incompletely	RB	RB	_	12	advmod	_	_
12	characterized	characterize	VBN	VBN	_	14	amod	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	More	more	JJR	JJR	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	regarding	regard	VBG	VBG	_	3	dep	_	_
5	signal	signal	NN	NN	_	7	compound	_	_
6	transduction	transduction	NN	NN	_	7	compound	_	_
7	events	event	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	occur	occur	VBP	VBP	_	7	acl:relcl	_	_
10	after	after	IN	IN	_	11	case	_	_
11	ligation	ligation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	T-cell	t-cell	NN	NN	_	16	compound	_	_
15	antigen	antigen	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	TCR	tcr	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	TCR	tcr	NN	NN	_	7	compound	_	_
7	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
8	requires	require	VBZ	VBZ	_	4	ccomp	_	_
9	both	both	CC	CC	_	13	cc:preconj	_	_
10	the	the	DT	DT	_	13	det	_	_
11	membrane	membrane	NN	NN	_	13	compound	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphatase	phosphatase	NN	NN	_	8	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	CD45	cd45	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Src-family	src-family	JJ	JJ	_	20	amod	_	_
20	kinase	kinase	NN	NN	_	13	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	Lck	lck	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	8	punct	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	result	result	VB	VB	_	8	xcomp	_	_
26	in	in	IN	IN	_	28	case	_	_
27	cellular	cellular	JJ	JJ	_	28	amod	_	_
28	activation	activation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	prior	prior	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	18	advcl	_	_
5	a	a	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	kinases	kinase	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	phosphatases	phosphatase	NNS	NNS	_	10	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	Fas	fas	NN	NN	_	15	compound	_	_
15	signaling	signaling	NN	NN	_	6	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	report	report	VBP	VBP	_	0	root	_	_
19	here	here	RB	RB	_	18	advmod	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	Fas	fas	NN	NN	_	22	compound	_	_
22	ligation	ligation	NN	NN	_	23	nsubj	_	_
23	induces	induce	VBZ	VBZ	_	18	ccomp	_	_
24	apoptosis	apoptosis	NN	NN	_	23	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	deficient	deficient	JJ	JJ	_	27	amod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	either	either	CC	CC	_	31	cc:preconj	_	_
31	CD45	cd45	NN	NN	_	28	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	Lck	lck	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	18	punct	_	_

1	Further	further	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	normal	normal	JJ	JJ	_	14	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	CD45-	cd45-	NN	NN	_	4	conj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	Lck-deficient	lck-deficient	JJ	JJ	_	6	conj	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	6	dep	_	_
11	,	,	,	,	_	14	punct	_	_
12	Fas	fas	NN	NN	_	13	compound	_	_
13	stimulation	stimulation	NN	NN	_	14	nsubj	_	_
14	results	result	VBZ	VBZ	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	Jun	jun	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	JNK	jnk	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	19	punct	_	_
24	a	a	DT	DT	_	26	det	_	_
25	proposed	proposed	JJ	JJ	_	26	amod	_	_
26	mediator	mediator	NN	NN	_	19	appos	_	_
27	of	of	IN	IN	_	30	case	_	_
28	stress	stress	NN	NN	_	30	compound	_	_
29	activation	activation	NN	NN	_	30	compound	_	_
30	pathways	pathway	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	5	nsubj	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	endogenous	endogenous	JJ	JJ	_	11	amod	_	_
10	ceramide	ceramide	NN	NN	_	11	compound	_	_
11	release	release	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	Fas-mediated	fas-mediated	JJ	JJ	_	14	amod	_	_
14	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
5	with	with	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	synthetic	synthetic	JJ	JJ	_	9	amod	_	_
8	ceramide	ceramide	NN	NN	_	9	compound	_	_
9	analog	analog	NN	NN	_	4	nmod	_	_
10	results	result	VBZ	VBZ	_	2	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	JNK	jnk	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	as	as	RB	RB	_	13	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	apoptosis	apoptosis	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
20	ceramide	ceramide	NN	NN	_	21	compound	_	_
21	release	release	NN	NN	_	19	dobj	_	_
22	occurs	occur	VBZ	VBZ	_	19	dep	_	_
23	proximal	proximal	JJ	JJ	_	22	xcomp	_	_
24	to	to	TO	TO	_	26	case	_	_
25	JNK	jnk	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	Fas	fas	NN	NN	_	29	compound	_	_
29	signaling	signaling	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	although	although	IN	IN	_	11	mark	_	_
6	CD45	cd45	NN	NN	_	11	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Lck	lck	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	required	require	VBN	VBN	_	19	advcl	_	_
12	for	for	IN	IN	_	14	case	_	_
13	Fas	fas	NN	NN	_	14	compound	_	_
14	signaling	signaling	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	JNK	jnk	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	play	play	VB	VB	_	3	ccomp	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	transducing	transduce	VBG	VBG	_	22	acl	_	_
24	distal	distal	JJ	JJ	_	25	amod	_	_
25	signals	signal	NNS	NNS	_	23	dobj	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	lead	lead	VBP	VBP	_	25	acl:relcl	_	_
28	to	to	TO	TO	_	29	case	_	_
29	apoptosis	apoptosis	NN	NN	_	27	nmod	_	_
30	after	after	IN	IN	_	32	case	_	_
31	Fas	fas	NN	NN	_	32	compound	_	_
32	ligation	ligation	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	down-regulation	down-regulation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	asthma	asthma	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
3	precise	precise	JJ	JJ	_	4	amod	_	_
4	mechanism	mechanism	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	action	action	NN	NN	_	4	nmod	_	_
7	remains	remain	VBZ	VBZ	_	13	advcl	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	elucidated	elucidate	VBN	VBN	_	7	xcomp	_	_
11	,	,	,	,	_	13	punct	_	_
12	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nsubj	_	_
13	represent	represent	VBP	VBP	_	0	root	_	_
14	the	the	DT	DT	_	17	det	_	_
15	most	most	RBS	RBS	_	16	advmod	_	_
16	effective	effective	JJ	JJ	_	17	amod	_	_
17	therapy	therapy	NN	NN	_	13	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	treatment	treatment	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	asthma	asthma	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Interactions	interaction	NNS	NNS	_	12	nsubjpass	_	_
2	between	between	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	AP-1	ap-1	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	5	conj	_	_
10	have	have	VBP	VBP	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	regulate	regulate	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	transcription	transcription	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	some	some	DT	DT	_	19	det	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	19	nmod	_	_
24	itself	itself	PRP	PRP	_	23	nmod:npmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	compare	compare	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	mRNA	mrna	NN	NN	_	11	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
21	obtained	obtain	VBN	VBN	_	20	acl	_	_
22	from	from	IN	IN	_	27	case	_	_
23	seven	seven	CD	CD	_	27	nummod	_	_
24	unstable	unstable	JJ	JJ	_	27	amod	_	_
25	untreated	untreated	JJ	JJ	_	24	dep	_	_
26	asthmatic	asthmatic	JJ	JJ	_	27	amod	_	_
27	patients	patient	NNS	NNS	_	21	nmod	_	_
28	who	who	WP	WP	_	31	nsubjpass	_	_
29	were	be	VBD	VBD	_	31	auxpass	_	_
30	subsequently	subsequently	RB	RB	_	31	advmod	_	_
31	treated	treat	VBN	VBN	_	27	acl:relcl	_	_
32	with	with	IN	IN	_	34	case	_	_
33	high	high	JJ	JJ	_	34	amod	_	_
34	doses	dose	NNS	NNS	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	parenteral	parenteral	JJ	JJ	_	37	amod	_	_
37	corticosteroid	corticosteroid	NN	NN	_	34	nmod	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	methyl	methyl	NN	NN	_	40	compound	_	_
40	prednisolone	prednisolone	NN	NN	_	34	appos	_	_
41	120	120	CD	CD	_	42	compound	_	_
42	mg/day	mg/day	NN	NN	_	40	amod	_	_
43	)	)	-RRB-	-RRB-	_	40	punct	_	_
44	for	for	IN	IN	_	46	case	_	_
45	10	10	CD	CD	_	46	nummod	_	_
46	days	day	NNS	NNS	_	31	nmod	_	_
47	.	.	.	.	_	7	punct	_	_

1	mRNA	mrna	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	after	after	IN	IN	_	7	case	_	_
6	RNA	rna	NN	NN	_	7	compound	_	_
7	extraction	extraction	NN	NN	_	4	nmod	_	_
8	using	use	VBG	VBG	_	7	acl	_	_
9	RNAzol	rnazol	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	analysed	analyse	VBN	VBN	_	4	conj	_	_
12	after	after	IN	IN	_	14	case	_	_
13	reverse	reverse	JJ	JJ	_	14	amod	_	_
14	transcriptase	transcriptase	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	by	by	IN	IN	_	19	case	_	_
17	polymerase	polymerase	NN	NN	_	19	compound	_	_
18	chain	chain	NN	NN	_	19	compound	_	_
19	reaction	reaction	NN	NN	_	4	nmod	_	_
20	using	use	VBG	VBG	_	19	acl	_	_
21	a	a	DT	DT	_	25	det	_	_
22	semiquantitative	semiquantitative	JJ	JJ	_	25	amod	_	_
23	competitive	competitive	JJ	JJ	_	25	amod	_	_
24	hybridization	hybridization	NN	NN	_	25	compound	_	_
25	assay	assay	NN	NN	_	20	dobj	_	_
26	.	.	.	.	_	4	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	asthmatic	asthmatic	JJ	JJ	_	3	amod	_	_
3	patients	patient	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	an	a	DT	DT	_	6	det	_	_
6	improvement	improvement	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	FEV1	fev1	NN	NN	_	10	compound	_	_
10	values	value	NNS	NNS	_	6	nmod	_	_
11	after	after	IN	IN	_	13	case	_	_
12	corticosteroid	corticosteroid	NN	NN	_	13	compound	_	_
13	treatment	treatment	NN	NN	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	per	per	IN	IN	_	16	amod	_	_
16	cent	cent	NN	NN	_	6	dep	_	_
17	of	of	IN	IN	_	19	case	_	_
18	predicted	predict	VBN	VBN	_	19	amod	_	_
19	value	value	NN	NN	_	16	nmod	_	_
20	68.28	68.28	CD	CD	_	16	dep	_	_
21	+/-	+/-	CC	CC	_	20	cc	_	_
22	4.93	4.93	CD	CD	_	20	conj	_	_
23	versus	versus	CC	CC	_	20	cc	_	_
24	95.57	95.57	CD	CD	_	20	conj	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	6.41	6.41	CD	CD	_	24	conj	_	_
27	,	,	,	,	_	16	punct	_	_
28	P	p	NN	NN	_	16	appos	_	_
29	&lt;	&lt;	JJR	JJR	_	28	amod	_	_
30	0.02	0.02	CD	CD	_	29	dep	_	_
31	)	)	-RRB-	-RRB-	_	16	punct	_	_
32	,	,	,	,	_	4	punct	_	_
33	and	and	CC	CC	_	4	cc	_	_
34	a	a	DT	DT	_	36	det	_	_
35	significant	significant	JJ	JJ	_	36	amod	_	_
36	decrease	decrease	NN	NN	_	48	nsubjpass	_	_
37	for	for	IN	IN	_	41	case	_	_
38	glucocorticoid	glucocorticoid	NN	NN	_	39	compound	_	_
39	receptor	receptor	NN	NN	_	41	compound	_	_
40	mRNA	mrna	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	36	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	P	p	NN	NN	_	36	dep	_	_
44	&lt;	&lt;	JJR	JJR	_	43	amod	_	_
45	0.02	0.02	CD	CD	_	44	dep	_	_
46	)	)	-RRB-	-RRB-	_	43	punct	_	_
47	was	be	VBD	VBD	_	48	auxpass	_	_
48	observed	observe	VBN	VBN	_	4	conj	_	_
49	in	in	IN	IN	_	51	case	_	_
50	their	they	PRP$	PRP$	_	51	nmod:poss	_	_
51	monocytes	monocyte	NNS	NNS	_	48	nmod	_	_
52	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	report	report	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	ex	ex	FW	FW	_	10	amod	_	_
9	vivo	vivo	FW	FW	_	8	dep	_	_
10	down-regulation	down-regulation	NN	NN	_	5	nmod	_	_
11	for	for	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	following	follow	VBG	VBG	_	20	case	_	_
19	corticosteroid	corticosteroid	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	either	either	CC	CC	_	6	cc:preconj	_	_
4	the	the	DT	DT	_	6	det	_	_
5	TCL1	tcl1	NN	NN	_	6	compound	_	_
6	oncogene	oncogene	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	or	or	CC	CC	_	6	cc	_	_
9	transcripts	transcript	NNS	NNS	_	6	conj	_	_
10	from	from	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	homologue	homologue	NN	NN	_	9	nmod	_	_
13	MTCP1/c6.1B	mtcp1/c6.1b	NN	NN	_	12	dep	_	_
14	,	,	,	,	_	1	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	leukaemic	leukaemic	JJ	JJ	_	1	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	non-leukaemic	non-leukaemic	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	from	from	IN	IN	_	24	case	_	_
22	ataxia	ataxia	NN	NN	_	24	compound	_	_
23	telangiectasia	telangiectasia	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Patients	patient	NNS	NNS	_	12	nsubj	_	_
2	with	with	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	recessively	recessively	RB	RB	_	5	advmod	_	_
5	inherited	inherit	VBN	VBN	_	6	amod	_	_
6	disorder	disorder	NN	NN	_	1	nmod	_	_
7	ataxia	ataxia	NN	NN	_	8	compound	_	_
8	telangiectasia	telangiectasia	NN	NN	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	A-T	a-t	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	have	have	VBP	VBP	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	high	high	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	specific	specific	JJ	JJ	_	19	amod	_	_
18	chromosome	chromosome	NN	NN	_	19	compound	_	_
19	translocations	translocation	NNS	NNS	_	15	nmod	_	_
20	which	which	WDT	WDT	_	24	nsubjpass	_	_
21	can	can	MD	MD	_	24	aux	_	_
22	be	be	VB	VB	_	24	auxpass	_	_
23	easily	easily	RB	RB	_	24	advmod	_	_
24	observed	observe	VBN	VBN	_	15	acl:relcl	_	_
25	in	in	IN	IN	_	28	case	_	_
26	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	12	cc	_	_
30	show	show	VB	VB	_	12	conj	_	_
31	a	a	DT	DT	_	34	det	_	_
32	greatly	greatly	RB	RB	_	33	advmod	_	_
33	increased	increase	VBN	VBN	_	34	amod	_	_
34	predisposition	predisposition	NN	NN	_	30	dobj	_	_
35	to	to	TO	TO	_	36	case	_	_
36	leukaemia/lymphoma	leukaemia/lymphoma	NN	NN	_	34	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	mainly	mainly	RB	RB	_	42	advmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	origin	origin	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	12	punct	_	_

1	Some	some	DT	DT	_	3	det	_	_
2	translocation	translocation	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	proliferate	proliferate	VBP	VBP	_	0	root	_	_
5	into	into	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	large	large	JJ	JJ	_	8	amod	_	_
8	clone	clone	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	develop	develop	VB	VB	_	4	conj	_	_
12	into	into	IN	IN	_	16	case	_	_
13	T	t	NN	NN	_	16	compound	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	prolymphocytic	prolymphocytic	NN	NN	_	16	compound	_	_
16	leukaemia	leukaemia	NN	NN	_	11	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	T-PLL	t-pll	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	time	time	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	diagnosis	diagnosis	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	T-PLL	t-pll	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	clone	clone	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	many	many	JJ	JJ	_	14	amod	_	_
13	more	more	JJR	JJR	_	14	dep	_	_
14	genetic	genetic	JJ	JJ	_	15	amod	_	_
15	changes	change	NNS	NNS	_	11	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	form	form	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	additional	additional	JJ	JJ	_	21	amod	_	_
21	translocations	translocation	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	T-PLL	t-pll	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	seen	see	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	non-A-T	non-a-t	JJ	JJ	_	7	amod	_	_
7	individuals	individual	NNS	NNS	_	4	nmod	_	_
8	where	where	WRB	WRB	_	27	advmod	_	_
9	expression	expression	NN	NN	_	27	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	TCL1	tcl1	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	at	at	IN	IN	_	15	case	_	_
15	14q32	14q32	NN	NN	_	12	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	or	or	CC	CC	_	12	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	c6.1B/MTCP1	c6.1b/mtcp1	NN	NN	_	21	compound	_	_
20	A1	a1	NN	NN	_	21	compound	_	_
21	transcript	transcript	NN	NN	_	12	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	at-Xq28	at-xq28	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	has	have	VBZ	VBZ	_	27	aux	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	demonstrated	demonstrate	VBN	VBN	_	7	acl:relcl	_	_
28	in	in	IN	IN	_	32	case	_	_
29	just	just	RB	RB	_	31	advmod	_	_
30	a	a	DT	DT	_	31	advmod	_	_
31	few	few	JJ	JJ	_	32	nummod	_	_
32	instances	instance	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	,	,	,	,	_	2	punct	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	expression	expression	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TCL1	tcl1	NN	NN	_	6	nmod	_	_
9	occurs	occur	VBZ	VBZ	_	2	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	leukaemic	leukaemic	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	A-T	a-t	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	chromosome	chromosome	NN	NN	_	20	compound	_	_
19	14	14	CD	CD	_	18	nummod	_	_
20	rearrangements	rearrangement	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TCL1	tcl1	NN	NN	_	1	nmod	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	occurs	occur	VBZ	VBZ	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	preleukaemic	preleukaemic	JJ	JJ	_	10	amod	_	_
9	clone	clone	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	A-T	a-t	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	10	nmod	_	_
14	containing	contain	VBG	VBG	_	10	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	translocation	translocation	NN	NN	_	14	dobj	_	_
18	alone	alone	RB	RB	_	17	advmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TCL1	tcl1	NN	NN	_	2	nmod	_	_
5	could	could	MD	MD	_	8	aux	_	_
6	also	also	RB	RB	_	8	advmod	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	randomly	randomly	RB	RB	_	11	advmod	_	_
11	selected	select	VBN	VBN	_	13	amod	_	_
12	A-T	a-t	JJ	JJ	_	13	amod	_	_
13	patients	patient	NNS	NNS	_	8	nmod	_	_
14	without	without	IN	IN	_	17	case	_	_
15	large	large	JJ	JJ	_	17	amod	_	_
16	cytogenetic	cytogenetic	JJ	JJ	_	17	amod	_	_
17	clones	clone	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	without	without	IN	IN	_	21	case	_	_
20	any	any	DT	DT	_	21	det	_	_
21	evidence	evidence	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	leukaemic	leukaemic	JJ	JJ	_	24	amod	_	_
24	change	change	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	expression	expression	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	B1	b1	NN	NN	_	9	compound	_	_
9	transcript	transcript	NN	NN	_	5	nmod	_	_
10	from	from	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	second	second	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	MTCP1	mtcp1	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	5	punct	_	_
17	occurred	occur	VBD	VBD	_	3	ccomp	_	_
18	at	at	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	relatively	relatively	RB	RB	_	21	advmod	_	_
21	high	high	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	17	nmod	_	_
23	only	only	RB	RB	_	27	advmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	two	two	CD	CD	_	27	nummod	_	_
26	T-PLL	t-pll	NN	NN	_	27	compound	_	_
27	tumours	tumour	NNS	NNS	_	17	nmod	_	_
28	from	from	IN	IN	_	30	case	_	_
29	A-T	a-t	NN	NN	_	30	compound	_	_
30	patients	patient	NNS	NNS	_	27	nmod	_	_
31	with	with	IN	IN	_	33	case	_	_
32	t(X;14)	t(x;14)	NN	NN	_	33	compound	_	_
33	translocations	translocation	NNS	NNS	_	30	nmod	_	_
34	whereas	whereas	IN	IN	_	42	mark	_	_
35	the	the	DT	DT	_	37	det	_	_
36	MTCP1/A1	mtcp1/a1	NN	NN	_	37	compound	_	_
37	transcript	transcript	NN	NN	_	42	nsubjpass	_	_
38	is	be	VBZ	VBZ	_	42	auxpass	_	_
39	much	much	RB	RB	_	41	advmod	_	_
40	more	more	RBR	RBR	_	41	advmod	_	_
41	widely	widely	RB	RB	_	42	advmod	_	_
42	expressed	express	VBN	VBN	_	17	advcl	_	_
43	in	in	IN	IN	_	45	case	_	_
44	both	both	CC	CC	_	45	cc:preconj	_	_
45	tumour	tumour	NN	NN	_	42	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	non	non	JJ	JJ	_	48	amod	_	_
48	tumour	tumour	NN	NN	_	45	conj	_	_
49	cells	cell	NNS	NNS	_	45	dep	_	_
50	of	of	IN	IN	_	51	case	_	_
51	A-T	a-t	NN	NN	_	45	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	non-A-T	non-a-t	JJ	JJ	_	51	conj	_	_
54	individuals	individual	NNS	NNS	_	51	dep	_	_
55	.	.	.	.	_	3	punct	_	_

1	Translocation	translocation	NN	NN	_	2	compound	_	_
2	breakpoints	breakpoint	NNS	NNS	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	three	three	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	campomelic	campomelic	JJ	JJ	_	8	amod	_	_
8	dysplasia	dysplasia	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	autosomal	autosomal	JJ	JJ	_	11	amod	_	_
11	sex	sex	NN	NN	_	8	conj	_	_
12	reversal	reversal	JJ	JJ	_	11	amod	_	_
13	map	map	NN	NN	_	0	root	_	_
14	more	more	JJR	JJR	_	16	advmod	_	_
15	than	than	IN	IN	_	14	mwe	_	_
16	130	130	CD	CD	_	17	nummod	_	_
17	kb	kb	NN	NN	_	13	nmod	_	_
18	from	from	IN	IN	_	17	case	_	_
19	SOX9	sox9	NN	NN	_	17	dep	_	_
20	.	.	.	.	_	13	punct	_	_

1	Campomelic	campomelic	JJ	JJ	_	2	amod	_	_
2	dysplasia	dysplasia	NN	NN	_	15	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CMPD1	cmpd1	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	autosomal	autosomal	JJ	JJ	_	9	amod	_	_
8	XY	xy	NN	NN	_	9	compound	_	_
9	sex	sex	NN	NN	_	2	conj	_	_
10	reversal	reversal	JJ	JJ	_	9	amod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SRA1	sra1	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	caused	cause	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	mutations	mutation	NNS	NNS	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	SRY-related	sry-related	JJ	JJ	_	21	amod	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	SOX9	sox9	NN	NN	_	21	dep	_	_
23	on	on	IN	IN	_	24	case	_	_
24	17q	17q	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	17q	17q	NN	NN	_	5	compound	_	_
5	breakpoints	breakpoint	NNS	NNS	_	17	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	four	four	CD	CD	_	10	nummod	_	_
8	CMPD1	cmpd1	NN	NN	_	10	compound	_	_
9	translocation	translocation	NN	NN	_	10	compound	_	_
10	cases	case	NNS	NNS	_	5	nmod	_	_
11	previously	previously	RB	RB	_	12	advmod	_	_
12	analyzed	analyze	VBN	VBN	_	10	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	us	we	PRP	PRP	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	others	other	NNS	NNS	_	14	conj	_	_
17	map	map	VBP	VBP	_	0	root	_	_
18	50	50	CD	CD	_	19	nummod	_	_
19	kb	kb	NN	NN	_	17	nmod	_	_
20	or	or	CC	CC	_	21	cc	_	_
21	more	more	JJR	JJR	_	19	nummod	_	_
22	from	from	IN	IN	_	19	case	_	_
23	SOX9	sox9	NN	NN	_	19	dep	_	_
24	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	present	present	VBP	VBP	_	0	root	_	_
5	clinical	clinical	JJ	JJ	_	11	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	cytogenetic	cytogenetic	JJ	JJ	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	molecular	molecular	JJ	JJ	_	5	conj	_	_
11	data	datum	NNS	NNS	_	4	dobj	_	_
12	from	from	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	new	new	JJ	JJ	_	16	amod	_	_
15	CMPD1/SRA1	cmpd1/sra1	NN	NN	_	16	compound	_	_
16	patient	patient	NN	NN	_	4	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	t(6;17)(q14;q24)	t(6;17)(q14;q24)	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Fluorescence	fluorescence	NN	NN	_	4	compound	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	situ	situ	FW	FW	_	2	dep	_	_
4	hybridization	hybridization	NN	NN	_	6	nsubj	_	_
5	has	have	VBZ	VBZ	_	6	aux	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	17q	17q	NN	NN	_	10	compound	_	_
10	breakpoint	breakpoint	NN	NN	_	14	nsubj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	case	case	NN	NN	_	10	nmod	_	_
14	maps	map	VBZ	VBZ	_	6	ccomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	same	same	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	as	as	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	breakpoints	breakpoint	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	other	other	JJ	JJ	_	26	amod	_	_
25	translocation	translocation	NN	NN	_	26	compound	_	_
26	cases	case	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	14	punct	_	_
28	at	at	IN	IN	_	29	case	_	_
29	least	least	JJS	JJS	_	30	nmod:npmod	_	_
30	130	130	CD	CD	_	31	nummod	_	_
31	kb	kb	NN	NN	_	14	nmod	_	_
32	from	from	IN	IN	_	31	case	_	_
33	SOX9	sox9	NN	NN	_	31	dep	_	_
34	.	.	.	.	_	6	punct	_	_

1	Likewise	likewise	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	breakpoints	breakpoint	NNS	NNS	_	13	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	two	two	CD	CD	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	described	describe	VBN	VBN	_	11	amod	_	_
11	cases	case	NNS	NNS	_	6	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	map	map	VBP	VBP	_	0	root	_	_
14	more	more	JJR	JJR	_	16	advmod	_	_
15	than	than	IN	IN	_	14	mwe	_	_
16	130	130	CD	CD	_	17	nummod	_	_
17	kb	kb	NN	NN	_	13	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	,	,	,	,	_	21	punct	_	_
20	as	as	IN	IN	_	21	dep	_	_
21	shown	show	VBN	VBN	_	17	conj	_	_
22	by	by	IN	IN	_	27	case	_	_
23	pulsed	pulsed	JJ	JJ	_	27	amod	_	_
24	field	field	NN	NN	_	27	compound	_	_
25	gel	gel	NN	NN	_	27	compound	_	_
26	electrophoresis	electrophoresis	NN	NN	_	27	compound	_	_
27	analysis	analysis	NN	NN	_	21	nmod	_	_
28	,	,	,	,	_	21	punct	_	_
29	at	at	IN	IN	_	32	amod	_	_
30	most	most	JJS	JJS	_	32	amod	_	_
31	400	400	CD	CD	_	32	nummod	_	_
32	kb	kb	NN	NN	_	21	nmod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	690	690	CD	CD	_	35	nummod	_	_
35	kb	kb	NN	NN	_	32	conj	_	_
36	from	from	IN	IN	_	32	case	_	_
37	SOX9	sox9	NN	NN	_	32	dep	_	_
38	.	.	.	.	_	13	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	16	advcl	_	_
3	a	a	DT	DT	_	7	det	_	_
4	SOX9	sox9	NN	NN	_	7	compound	_	_
5	coding	coding	NN	NN	_	7	compound	_	_
6	sequence	sequence	NN	NN	_	7	compound	_	_
7	polymorphism	polymorphism	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	16	punct	_	_
9	expression	expression	NN	NN	_	16	nsubjpass	_	_
10	of	of	IN	IN	_	13	case	_	_
11	both	both	DT	DT	_	13	det	_	_
12	SOX9	sox9	NN	NN	_	13	compound	_	_
13	alleles	allele	NNS	NNS	_	9	nmod	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	reverse	reverse	JJ	JJ	_	20	amod	_	_
20	transcriptase	transcriptase	NN	NN	_	23	compound	_	_
21	polymerase	polymerase	NN	NN	_	23	compound	_	_
22	chain	chain	NN	NN	_	23	compound	_	_
23	reaction	reaction	NN	NN	_	16	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	lymphoblastoid	lymphoblastoid	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	from	from	IN	IN	_	28	case	_	_
28	one	one	CD	CD	_	26	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	translocation	translocation	NN	NN	_	32	compound	_	_
32	cases	case	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	In	in	FW	FW	_	6	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	anergized	anergize	VBN	VBN	_	6	amod	_	_
4	CD4+	cd4+	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	express	express	VBP	VBP	_	0	root	_	_
8	perturbed	perturb	VBN	VBN	_	9	amod	_	_
9	AP-1	ap-1	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	conj	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	9	dep	_	_
15	.	.	.	.	_	7	punct	_	_

1	Anergy	anergy	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	major	major	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	ensure	ensure	VB	VB	_	5	acl	_	_
8	antigen-specific	antigen-specific	JJ	JJ	_	9	amod	_	_
9	tolerance	tolerance	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	adult	adult	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	8	advmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	anergy	anergy	NN	NN	_	8	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	mainly	mainly	RB	RB	_	8	advmod	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	studied	study	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	level	level	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	used	use	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	T-cell-activating	t-cell-activating	JJ	JJ	_	9	amod	_	_
9	superantigen	superantigen	NN	NN	_	6	dobj	_	_
10	staphylococcal	staphylococcal	NN	NN	_	12	compound	_	_
11	enterotoxin	enterotoxin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SEA	sea	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	investigate	investigate	VB	VB	_	6	advcl	_	_
18	molecular	molecular	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T-lymphocyte	t-lymphocyte	NN	NN	_	22	compound	_	_
22	anergy	anergy	NN	NN	_	19	nmod	_	_
23	in	in	FW	FW	_	22	amod	_	_
24	vivo	vivo	FW	FW	_	23	dep	_	_
25	.	.	.	.	_	6	punct	_	_

1	Injection	injection	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	SEA	sea	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	adult	adult	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	1	nmod	_	_
7	activates	activate	VBZ	VBZ	_	0	root	_	_
8	CD4+	cd4+	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	dobj	_	_
11	expressing	express	VBG	VBG	_	10	acl	_	_
12	certain	certain	JJ	JJ	_	21	amod	_	_
13	T-cell	t-cell	NN	NN	_	21	compound	_	_
14	receptor	receptor	NN	NN	_	21	compound	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	TCR	tcr	NN	NN	_	21	compound	_	_
17	)	)	-RRB-	-RRB-	_	21	punct	_	_
18	variable	variable	JJ	JJ	_	21	amod	_	_
19	region	region	NN	NN	_	21	compound	_	_
20	beta-chain	beta-chain	IN	IN	_	21	amod	_	_
21	families	family	NNS	NNS	_	11	dobj	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	induces	induce	VBZ	VBZ	_	7	conj	_	_
24	strong	strong	JJ	JJ	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	rapid	rapid	JJ	JJ	_	24	conj	_	_
27	production	production	NN	NN	_	23	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	interleukin	interleukin	NN	NN	_	27	nmod	_	_
30	2	2	CD	CD	_	29	nummod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	IL-2	il-2	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	repeated	repeated	JJ	JJ	_	5	amod	_	_
5	injections	injection	NNS	NNS	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	SEA	sea	NN	NN	_	5	nmod	_	_
8	cause	cause	VBP	VBP	_	0	root	_	_
9	CD4+	cd4+	JJ	JJ	_	10	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	deletion	deletion	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	anergy	anergy	NN	NN	_	11	conj	_	_
14	in	in	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	remaining	remain	VBG	VBG	_	19	amod	_	_
17	CD4+	cd4+	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	characterized	characterize	VBN	VBN	_	11	acl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	reduced	reduce	VBN	VBN	_	24	amod	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	IL-2	il-2	NN	NN	_	24	nmod	_	_
27	at	at	IN	IN	_	28	case	_	_
28	mRNA	mrna	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	protein	protein	NN	NN	_	28	conj	_	_
31	levels	level	NNS	NNS	_	28	dep	_	_
32	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	AP-1	ap-1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	NF-AT	nf-at	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	octamer	octamer	NN	NN	_	16	compound	_	_
14	binding	binding	NN	NN	_	16	compound	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	5	conj	_	_
17	,	,	,	,	_	5	punct	_	_
18	which	which	WDT	WDT	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	known	know	VBN	VBN	_	5	acl:relcl	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	involved	involve	VBN	VBN	_	20	xcomp	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regulation	regulation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	IL-2	il-2	NN	NN	_	31	compound	_	_
29	gene	gene	NN	NN	_	31	compound	_	_
30	promoter	promoter	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Large	large	JJ	JJ	_	2	amod	_	_
2	amounts	amount	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AP-1	ap-1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	4	conj	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	quantities	quantity	NNS	NNS	_	2	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-AT	nf-at	NN	NN	_	10	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	20	case	_	_
16	SEA-activated	sea-activated	JJ	JJ	_	20	amod	_	_
17	CD4+	cd4+	JJ	JJ	_	20	amod	_	_
18	spleen	spleen	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	whereas	whereas	IN	IN	_	30	mark	_	_
23	Oct-1	oct-1	NN	NN	_	28	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Oct-2	oct-2	NN	NN	_	23	conj	_	_
26	DNA	dna	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	30	nsubj	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	similar	similar	JJ	JJ	_	14	advcl	_	_
31	in	in	IN	IN	_	33	case	_	_
32	both	both	CC	CC	_	33	cc:preconj	_	_
33	resting	rest	VBG	VBG	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	activated	activate	VBN	VBN	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	33	conj	_	_
38	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	anergic	anergic	JJ	JJ	_	7	amod	_	_
5	CD4+	cd4+	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	contained	contain	VBD	VBD	_	0	root	_	_
9	severely	severely	RB	RB	_	10	advmod	_	_
10	reduced	reduce	VBN	VBN	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	AP-1	ap-1	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Fos/Jun-containing	fos/jun-containing	JJ	JJ	_	17	amod	_	_
16	NF-AT	nf-at	NN	NN	_	17	compound	_	_
17	complexes	complex	NNS	NNS	_	13	conj	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	expressed	express	VBD	VBD	_	8	conj	_	_
20	significant	significant	JJ	JJ	_	21	amod	_	_
21	amounts	amount	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Oct	oct	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	24	conj	_	_
29	after	after	IN	IN	_	31	case	_	_
30	SEA	sea	NN	NN	_	31	compound	_	_
31	stimulation	stimulation	NN	NN	_	19	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Resolution	resolution	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	1	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	predominant	predominant	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	p50-p65	p50-p65	JJ	JJ	_	12	amod	_	_
12	heterodimers	heterodimer	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	activated	activate	VBN	VBN	_	17	amod	_	_
15	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	9	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	while	while	IN	IN	_	23	mark	_	_
20	anergic	anergic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	23	nsubj	_	_
22	mainly	mainly	RB	RB	_	23	advmod	_	_
23	expressed	express	VBD	VBD	_	7	advcl	_	_
24	the	the	DT	DT	_	28	det	_	_
25	transcriptionally	transcriptionally	RB	RB	_	26	advmod	_	_
26	inactive	inactive	JJ	JJ	_	28	amod	_	_
27	p50	p50	NN	NN	_	28	compound	_	_
28	homodimer	homodimer	NN	NN	_	23	dobj	_	_
29	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	alterations	alteration	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	likely	likely	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	responsible	responsible	JJ	JJ	_	7	xcomp	_	_
11	for	for	IN	IN	_	12	case	_	_
12	repression	repression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-2	il-2	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	anergic	anergic	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	purification	purification	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	protein	protein	NN	NN	_	9	compound	_	_
7	kinase	kinase	NN	NN	_	9	compound	_	_
8	C	c	NN	NN	_	9	compound	_	_
9	substrate	substrate	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	as	as	IN	IN	_	4	case	_	_
3	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	4	amod	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LSP1	lsp1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	.	.	.	.	_	1	punct	_	_

1	Incubation	incubation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	B-chronic	b-chronic	JJ	JJ	_	5	amod	_	_
4	lymphocytic	lymphocytic	JJ	JJ	_	5	amod	_	_
5	leukemia	leukemia	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	B-CLL	b-cll	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	esters	ester	NNS	NNS	_	1	nmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	major	major	JJ	JJ	_	21	amod	_	_
20	PKC	pkc	NN	NN	_	21	compound	_	_
21	substrates	substrate	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	MARCKS	marcks	NN	NN	_	21	appos	_	_
24	(	(	-LRB-	-LRB-	_	30	punct	_	_
25	myristoylated	myristoylate	VBN	VBN	_	30	amod	_	_
26	,	,	,	,	_	25	punct	_	_
27	alanine-rich	alanine-rich	JJ	JJ	_	25	dep	_	_
28	C	c	NN	NN	_	30	compound	_	_
29	kinase	kinase	NN	NN	_	30	compound	_	_
30	substrate	substrate	NN	NN	_	23	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	23	cc	_	_
33	MRP	mrp	NN	NN	_	23	conj	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	MARCKS-related	marcks-related	JJ	JJ	_	36	amod	_	_
36	protein	protein	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	,	,	,	,	_	21	punct	_	_
39	and	and	CC	CC	_	21	cc	_	_
40	of	of	IN	IN	_	43	case	_	_
41	a	a	DT	DT	_	43	det	_	_
42	third	third	JJ	JJ	_	43	amod	_	_
43	protein	protein	NN	NN	_	21	conj	_	_
44	,	,	,	,	_	43	punct	_	_
45	with	with	IN	IN	_	48	case	_	_
46	an	a	DT	DT	_	48	det	_	_
47	apparent	apparent	JJ	JJ	_	48	amod	_	_
48	m.w.	m.w.	NN	NN	_	43	nmod	_	_
49	of	of	IN	IN	_	50	case	_	_
50	60,000	60,000	CD	CD	_	48	nmod	_	_
51	that	that	WDT	WDT	_	59	nsubj	_	_
52	was	be	VBD	VBD	_	59	cop	_	_
53	the	the	DT	DT	_	59	det	_	_
54	most	most	RBS	RBS	_	55	advmod	_	_
55	prominent	prominent	JJ	JJ	_	59	amod	_	_
56	protein	protein	NN	NN	_	59	compound	_	_
57	kinase	kinase	NN	NN	_	59	compound	_	_
58	C	c	NN	NN	_	59	compound	_	_
59	substrate	substrate	NN	NN	_	43	acl:relcl	_	_
60	in	in	IN	IN	_	62	case	_	_
61	these	these	DT	DT	_	62	det	_	_
62	cells	cell	NNS	NNS	_	59	nmod	_	_
63	.	.	.	.	_	13	punct	_	_

1	p60	p60	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	8	nsubj	_	_
3	was	be	VBD	VBD	_	8	cop	_	_
4	time	time	NN	NN	_	8	nmod:npmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	PMA	pma	NN	NN	_	7	compound	_	_
7	dose	dose	NN	NN	_	4	conj	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	8	conj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	cell-permeable	cell-permeable	JJ	JJ	_	15	amod	_	_
15	diacylglycerol	diacylglycerol	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	15	cc	_	_
18	not	not	RB	RB	_	22	neg	_	_
19	by	by	IN	IN	_	22	case	_	_
20	inactive	inactive	JJ	JJ	_	22	amod	_	_
21	phorbol	phorbol	NN	NN	_	22	compound	_	_
22	esters	ester	NNS	NNS	_	15	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	Two-dimensional	two-dimensional	JJ	JJ	_	3	amod	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	protein	protein	NN	NN	_	8	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	8	compound	_	_
8	pattern	pattern	NN	NN	_	3	nmod	_	_
9	from	from	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	line	line	NN	NN	_	14	compound	_	_
14	CESS	cess	NN	NN	_	8	nmod	_	_
15	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	identity	identity	NN	NN	_	15	dobj	_	_
18	between	between	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p60	p60	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	nmod	_	_
22	expressed	express	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	26	case	_	_
24	this	this	DT	DT	_	26	det	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	that	that	DT	DT	_	21	conj	_	_
29	expressed	express	VBN	VBN	_	28	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	B-CLL	b-cll	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	p60	p60	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	purified	purify	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	6	case	_	_
5	CESS	cess	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	peptide	peptide	NN	NN	_	9	compound	_	_
9	microsequencing	microsequencing	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	9	nmod	_	_
13	revealed	reveal	VBD	VBD	_	3	conj	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	it	it	PRP	PRP	_	18	nsubj	_	_
16	was	be	VBD	VBD	_	18	cop	_	_
17	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	13	ccomp	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	LSP1	lsp1	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	18	punct	_	_
24	that	that	WDT	WDT	_	27	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	27	auxpass	_	_
26	here	here	RB	RB	_	27	advmod	_	_
27	characterized	characterize	VBN	VBN	_	18	dep	_	_
28	as	as	IN	IN	_	34	case	_	_
29	the	the	DT	DT	_	34	det	_	_
30	most	most	RBS	RBS	_	31	advmod	_	_
31	prominent	prominent	JJ	JJ	_	34	amod	_	_
32	protein	protein	NN	NN	_	34	compound	_	_
33	kinase	kinase	NN	NN	_	34	compound	_	_
34	C	c	NN	NN	_	27	nmod	_	_
35	substrate	substrate	JJ	JJ	_	34	amod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	34	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Cross-linking	cross-linking	JJ	JJ	_	2	amod	_	_
2	CD40	cd40	NN	NN	_	7	nsubj	_	_
3	on	on	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	preferentially	preferentially	RB	RB	_	7	advmod	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	stress-activated	stress-activated	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	kinases	kinase	NNS	NNS	_	7	dobj	_	_
11	rather	rather	RB	RB	_	10	cc	_	_
12	than	than	IN	IN	_	11	mwe	_	_
13	mitogen-activated	mitogen-activated	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	kinases	kinase	NNS	NNS	_	10	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	B	b	NN	NN	_	5	compound	_	_
3	cell-associated	cell-associate	VBD	VBD	_	5	amod	_	_
4	surface	surface	NN	NN	_	5	compound	_	_
5	molecule	molecule	NN	NN	_	7	nsubj	_	_
6	CD40	cd40	NN	NN	_	5	dep	_	_
7	plays	play	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	key	key	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	16	case	_	_
12	T	t	NN	NN	_	16	compound	_	_
13	cell-dependent	cell-dependent	JJ	JJ	_	16	amod	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	maturation	maturation	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	as	as	IN	IN	_	29	dep	_	_
19	individuals	individual	NNS	NNS	_	29	dep	_	_
20	with	with	IN	IN	_	21	case	_	_
21	defects	defect	NNS	NNS	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	either	either	CC	CC	_	24	cc:preconj	_	_
24	CD40	cd40	NN	NN	_	21	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	ligand	ligand	NN	NN	_	24	conj	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	impaired	impaired	JJ	JJ	_	7	advcl	_	_
30	in	in	IN	IN	_	34	case	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	34	compound	_	_
32	isotype	isotype	NN	NN	_	34	compound	_	_
33	class	class	NN	NN	_	34	compound	_	_
34	switching	switching	NN	NN	_	29	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	germinal	germinal	JJ	JJ	_	38	amod	_	_
37	center	center	NN	NN	_	38	compound	_	_
38	formation	formation	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	7	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	downstream	downstream	JJ	JJ	_	5	amod	_	_
5	effectors	effector	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	including	include	VBG	VBG	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	Lyn	lyn	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	phosphatidylinositol-3-kinase	phosphatidylinositol-3-kinase	NN	NN	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	PI-3	pi-3	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	11	punct	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	11	conj	_	_
26	,	,	,	,	_	25	punct	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	25	appos	_	_
29	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	stress-activated	stress-activated	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	kinases	kinase	NNS	NNS	_	15	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SAPK	sapk	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	6	ccomp	_	_
16	after	after	IN	IN	_	18	case	_	_
17	CD40	cd40	NN	NN	_	18	compound	_	_
18	cross-linking	cross-linking	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	23	case	_	_
20	various	various	JJ	JJ	_	23	amod	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	18	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	tonsillar	tonsillar	JJ	JJ	_	28	amod	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	rapid	rapid	JJ	JJ	_	0	root	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	transient	transient	JJ	JJ	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	4	conj	_	_
10	through	through	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	cyclosporin	cyclosporin	NN	NN	_	14	compound	_	_
13	A-insensitive	a-insensitive	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	6	nsubj	_	_
6	appears	appear	VBZ	VBZ	_	0	root	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	rely	rely	VB	VB	_	6	xcomp	_	_
10	on	on	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	CD40	cd40	NN	NN	_	3	compound	_	_
3	ligation	ligation	NN	NN	_	5	nsubj	_	_
4	strongly	strongly	RB	RB	_	5	advmod	_	_
5	activates	activate	VBZ	VBZ	_	17	advcl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	SAPKs	sapk	NNS	NNS	_	5	dobj	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	up	up	RB	RB	_	11	advmod	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	25-fold	25-fold	JJ	JJ	_	5	dep	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	17	punct	_	_
14	it	it	PRP	PRP	_	17	nsubj	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	affect	affect	VB	VB	_	0	root	_	_
18	members	member	NNS	NNS	_	17	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	mitogen-activated	mitogen-activated	JJ	JJ	_	24	amod	_	_
22	protein	protein	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MAPK	mapk	NN	NN	_	18	dep	_	_
27	;	;	:	:	_	26	punct	_	_
28	ERK1	erk1	NN	NN	_	26	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	ERK2	erk2	NN	NN	_	28	conj	_	_
31	)	)	-RRB-	-RRB-	_	26	punct	_	_
32	.	.	.	.	_	17	punct	_	_

1	Consistent	consistent	JJ	JJ	_	8	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	CD40	cd40	NN	NN	_	7	compound	_	_
7	signals	signal	NNS	NNS	_	8	nsubj	_	_
8	up-regulate	up-regulate	VBP	VBP	_	0	root	_	_
9	c-jun	c-jun	NN	NN	_	8	dobj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	c-fos	c-fos	NN	NN	_	9	conj	_	_
13	mRNA	mrna	NN	NN	_	9	dep	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	alter	alter	VBP	VBP	_	8	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	15	dobj	_	_
19	ATF2	atf2	NN	NN	_	18	dep	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	19	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Raf-1	raf-1	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	CD40	cd40	NN	NN	_	5	compound	_	_
5	signaling	signaling	NN	NN	_	7	nsubj	_	_
6	preferentially	preferentially	RB	RB	_	7	advmod	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	SAPK	sapk	NN	NN	_	7	dobj	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	MAPK	mapk	NN	NN	_	8	conj	_	_
12	.	.	.	.	_	7	punct	_	_

1	GATA	gata	NN	NN	_	3	compound	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	associate	associate	VBP	VBP	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	class	class	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	bodies	body	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	erythroblasts	erythroblast	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	megakaryocytes	megakaryocyte	NNS	NNS	_	13	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	distribution	distribution	NN	NN	_	13	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	GATA	gata	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	murine	murine	JJ	JJ	_	11	amod	_	_
10	haemopoietic	haemopoietic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	indirect	indirect	JJ	JJ	_	16	amod	_	_
16	immunofluorescence	immunofluorescence	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	bright	bright	JJ	JJ	_	1	dep	_	_
3	foci	focus	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	GATA-1	gata-1	NN	NN	_	6	compound	_	_
6	fluorescence	fluorescence	NN	NN	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	erythroleukaemia	erythroleukaemia	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	primary	primary	JJ	JJ	_	15	amod	_	_
14	murine	murine	JJ	JJ	_	15	amod	_	_
15	erythroblasts	erythroblast	NNS	NNS	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	megakaryocytes	megakaryocyte	NNS	NNS	_	11	conj	_	_
18	,	,	,	,	_	8	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	addition	addition	NN	NN	_	8	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	diffuse	diffuse	VB	VB	_	24	amod	_	_
23	nucleoplasmic	nucleoplasmic	JJ	JJ	_	22	dep	_	_
24	localization	localization	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	foci	focus	NNS	NNS	_	19	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	7	nsubjpass	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	preferentially	preferentially	RB	RB	_	7	advmod	_	_
7	found	find	VBN	VBN	_	2	acl:relcl	_	_
8	adjacent	adjacent	JJ	JJ	_	7	xcomp	_	_
9	to	to	TO	TO	_	10	case	_	_
10	nucleoli	nucleoli	JJ	JJ	_	8	nmod	_	_
11	or	or	CC	CC	_	8	cc	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	periphery	periphery	NN	NN	_	8	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	represent	represent	VB	VB	_	0	root	_	_
20	sites	site	NNS	NNS	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	active	active	JJ	JJ	_	23	amod	_	_
23	transcription	transcription	NN	NN	_	20	nmod	_	_
24	or	or	CC	CC	_	20	cc	_	_
25	binding	binding	NN	NN	_	20	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	GATA-1	gata-1	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	consensus	consensus	NN	NN	_	30	compound	_	_
30	sites	site	NNS	NNS	_	25	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	beta-globin	beta-globin	NN	NN	_	34	compound	_	_
34	loci	locus	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	19	punct	_	_

1	Immunoelectron	immunoelectron	NN	NN	_	2	compound	_	_
2	microscopy	microscopy	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	intensely	intensely	RB	RB	_	8	advmod	_	_
8	labelled	label	VBN	VBN	_	9	amod	_	_
9	structures	structure	NNS	NNS	_	5	nmod	_	_
10	likely	likely	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	represent	represent	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	GATA-1	gata-1	NN	NN	_	15	compound	_	_
15	foci	focus	NNS	NNS	_	12	dobj	_	_
16	seen	see	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	immunofluorescence	immunofluorescence	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GATA-1	gata-1	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	bodies	body	NNS	NNS	_	5	nsubj	_	_
5	differed	differ	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	10	case	_	_
7	previously	previously	RB	RB	_	8	advmod	_	_
8	described	describe	VBN	VBN	_	10	amod	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	structures	structure	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	there	there	EX	EX	_	13	expl	_	_
13	was	be	VBD	VBD	_	5	conj	_	_
14	no	no	DT	DT	_	15	neg	_	_
15	co-localization	co-localization	NN	NN	_	13	nsubj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	antigens	antigen	NNS	NNS	_	15	nmod	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	RNA	rna	NN	NN	_	22	compound	_	_
22	processing	processing	NN	NN	_	19	nmod	_	_
23	or	or	CC	CC	_	18	cc	_	_
24	other	other	JJ	JJ	_	27	amod	_	_
25	ubiquitous	ubiquitous	JJ	JJ	_	27	amod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	Spl	spl	NN	NN	_	18	conj	_	_
28	,	,	,	,	_	27	punct	_	_
29	c-Jun	c-jun	NN	NN	_	27	conj	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	TBP	tbp	NN	NN	_	27	conj	_	_
32	)	)	-RRB-	-RRB-	_	27	punct	_	_
33	or	or	CC	CC	_	27	cc	_	_
34	haemopoietic	haemopoietic	JJ	JJ	_	39	amod	_	_
35	(	(	-LRB-	-LRB-	_	39	punct	_	_
36	NF-E2	nf-e2	NN	NN	_	39	compound	_	_
37	)	)	-RRB-	-RRB-	_	39	punct	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factors	factor	NNS	NNS	_	27	conj	_	_
40	.	.	.	.	_	5	punct	_	_

1	Interestingly	interestingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	GATA-2	gata-2	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	GATA-3	gata-3	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	3	conj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	localized	localize	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	same	same	JJ	JJ	_	13	amod	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	bodies	body	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	13	nmod	_	_
17	co-expressing	co-express	VBG	VBG	_	16	acl	_	_
18	GATA-1	gata-1	NN	NN	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-2	-2	CD	CD	_	18	conj	_	_
21	or	or	CC	CC	_	18	cc	_	_
22	GATA-1	gata-1	NN	NN	_	18	conj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	-3	-3	CD	CD	_	22	conj	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	products	product	NNS	NNS	_	18	dep	_	_
27	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	distribution	distribution	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	,	,	,	,	_	10	punct	_	_
7	thus	thus	RB	RB	_	8	advmod	_	_
8	far	far	RB	RB	_	10	advmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	unique	unique	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	GATA	gata	NN	NN	_	15	compound	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	suggests	suggest	VBZ	VBZ	_	10	conj	_	_
18	a	a	DT	DT	_	20	det	_	_
19	protein-protein	protein-protein	JJ	JJ	_	20	amod	_	_
20	interaction	interaction	NN	NN	_	17	dobj	_	_
21	with	with	IN	IN	_	23	case	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	components	component	NNS	NNS	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	bodies	body	NNS	NNS	_	23	nmod	_	_
28	via	via	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	GATA	gata	NN	NN	_	33	compound	_	_
31	zinc	zinc	NN	NN	_	33	compound	_	_
32	finger	finger	NN	NN	_	33	compound	_	_
33	domain	domain	NN	NN	_	20	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IL-6	il-6	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	2	nmod	_	_
6	transcription	transcription	NN	NN	_	5	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	expression	expression	NN	NN	_	6	conj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-4	il-4	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-10	il-10	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	2	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	IL-4	il-4	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-10	il-10	NN	NN	_	1	conj	_	_
4	inhibit	inhibit	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	4	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	conj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	25	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	5	nmod	_	_
10	on	on	IN	IN	_	14	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	post-transcriptional	post-transcriptional	JJ	JJ	_	11	conj	_	_
14	regulation	regulation	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	IL-6	il-6	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	IL-4	il-4	NN	NN	_	9	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IL-10	il-10	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	25	punct	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	studied	study	VBD	VBD	_	0	root	_	_
26	IL-6	il-6	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	25	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	expression	expression	NN	NN	_	30	compound	_	_
30	level	level	NN	NN	_	27	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	IL-6	il-6	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	30	nmod	_	_
34	,	,	,	,	_	27	punct	_	_
35	IL-6	il-6	NN	NN	_	37	compound	_	_
36	promoter	promoter	NN	NN	_	37	compound	_	_
37	activity	activity	NN	NN	_	27	conj	_	_
38	,	,	,	,	_	27	punct	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	27	conj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	NF-kappaB	nf-kappab	NN	NN	_	40	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	NF-IL-6	nf-il-6	NN	NN	_	42	conj	_	_
45	,	,	,	,	_	27	punct	_	_
46	and	and	CC	CC	_	27	cc	_	_
47	IL-6	il-6	NN	NN	_	49	compound	_	_
48	mRNA	mrna	NN	NN	_	49	compound	_	_
49	stability	stability	NN	NN	_	27	conj	_	_
50	in	in	IN	IN	_	54	case	_	_
51	human	human	JJ	JJ	_	54	amod	_	_
52	monocytic	monocytic	JJ	JJ	_	54	amod	_	_
53	cell	cell	NN	NN	_	54	compound	_	_
54	lines	line	NNS	NNS	_	27	nmod	_	_
55	,	,	,	,	_	54	punct	_	_
56	THP-1	thp-1	NN	NN	_	54	appos	_	_
57	and	and	CC	CC	_	56	cc	_	_
58	U937	u937	NN	NN	_	56	conj	_	_
59	,	,	,	,	_	54	punct	_	_
60	stimulated	stimulate	VBN	VBN	_	54	acl	_	_
61	by	by	IN	IN	_	62	case	_	_
62	PMA	pma	NN	NN	_	60	nmod	_	_
63	and	and	CC	CC	_	62	cc	_	_
64	LPS	lps	NN	NN	_	62	conj	_	_
65	in	in	IN	IN	_	67	case	_	_
66	the	the	DT	DT	_	67	det	_	_
67	absence	absence	NN	NN	_	60	nmod	_	_
68	or	or	CC	CC	_	67	cc	_	_
69	the	the	DT	DT	_	70	det	_	_
70	presence	presence	NN	NN	_	67	conj	_	_
71	of	of	IN	IN	_	72	case	_	_
72	IL-4	il-4	NN	NN	_	67	nmod	_	_
73	or	or	CC	CC	_	72	cc	_	_
74	IL-10	il-10	NN	NN	_	72	conj	_	_
75	.	.	.	.	_	25	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	IL-4	il-4	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-10	il-10	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	seen	see	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	inhibit	inhibit	VB	VB	_	6	xcomp	_	_
9	IL-6	il-6	NN	NN	_	10	compound	_	_
10	production	production	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	IL-6	il-6	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	both	both	DT	DT	_	21	det	_	_
19	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	8	nmod	_	_
22	studied	study	VBN	VBN	_	21	acl	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	chloramphenicol	chloramphenicol	NN	NN	_	4	compound	_	_
3	acetyltransferase	acetyltransferase	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	28	nmod	_	_
5	,	,	,	,	_	28	punct	_	_
6	utilizing	utilize	VBG	VBG	_	28	advcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transient	transient	JJ	JJ	_	9	amod	_	_
9	transfection	transfection	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	chloramphenicol	chloramphenicol	NN	NN	_	15	compound	_	_
13	acetyltransferase	acetyltransferase	NN	NN	_	15	compound	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	plasmid	plasmid	NN	NN	_	9	nmod	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	IL-6	il-6	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	dobj	_	_
21	,	,	,	,	_	28	punct	_	_
22	IL-4	il-4	NN	NN	_	28	nsubj	_	_
23	,	,	,	,	_	22	punct	_	_
24	but	but	CC	CC	_	25	cc	_	_
25	not	not	RB	RB	_	22	cc	_	_
26	IL-10	il-10	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	suppressed	suppress	VBD	VBD	_	0	root	_	_
29	the	the	DT	DT	_	31	det	_	_
30	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
31	activity	activity	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	IL-6	il-6	NN	NN	_	36	compound	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	31	nmod	_	_
37	stimulated	stimulate	VBN	VBN	_	36	acl	_	_
38	by	by	IN	IN	_	39	case	_	_
39	PMA	pma	NN	NN	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	LPS	lps	NN	NN	_	39	conj	_	_
42	.	.	.	.	_	28	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	IL-4	il-4	NN	NN	_	13	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	7	cc	_	_
11	IL-10	il-10	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	inhibited	inhibit	VBD	VBD	_	5	ccomp	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	IL-4	il-4	NN	NN	_	25	nsubj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IL-10	il-10	NN	NN	_	20	conj	_	_
23	did	do	VBD	VBD	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	affect	affect	VB	VB	_	13	conj	_	_
26	NF-IL-6	nf-il-6	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	5	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	IL-10	il-10	NN	NN	_	7	nsubj	_	_
7	enhanced	enhance	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	degradation	degradation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-6	il-6	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	mRNA	mrna	NN	NN	_	17	compound	_	_
16	stability	stability	NN	NN	_	17	compound	_	_
17	assay	assay	NN	NN	_	7	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IL-4	il-4	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	inhibit	inhibit	VB	VB	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-6	il-6	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	affecting	affect	VBG	VBG	_	7	advcl	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	dobj	_	_
19	,	,	,	,	_	7	punct	_	_
20	while	while	IN	IN	_	23	mark	_	_
21	IL-10	il-10	NN	NN	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	inhibit	inhibit	VB	VB	_	7	advcl	_	_
24	the	the	DT	DT	_	27	det	_	_
25	IL-6	il-6	NN	NN	_	27	compound	_	_
26	mRNA	mrna	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	23	dobj	_	_
28	post-transcriptionally	post-transcriptionally	RB	RB	_	23	advmod	_	_
29	,	,	,	,	_	23	punct	_	_
30	without	without	IN	IN	_	31	mark	_	_
31	suppressing	suppress	VBG	VBG	_	23	advcl	_	_
32	promoter	promoter	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	3	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	conclude	conclude	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	IL-4	il-4	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-10	il-10	NN	NN	_	6	conj	_	_
9	inhibit	inhibit	VBP	VBP	_	4	ccomp	_	_
10	IL-6	il-6	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	different	different	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Autocrine	autocrine	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	interferon-gamma	interferon-gamma	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	STAT	stat	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	following	follow	VBG	VBG	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	engagement	engagement	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	receptor/CD3	receptor/cd3	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	co-stimulatory	co-stimulatory	JJ	JJ	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	13	conj	_	_
17	,	,	,	,	_	6	punct	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	results	result	VBZ	VBZ	_	6	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	triggering	triggering	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	several	several	JJ	JJ	_	26	amod	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	pathways	pathway	NNS	NNS	_	22	nmod	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	lead	lead	VBP	VBP	_	26	acl:relcl	_	_
29	rapidly	rapidly	RB	RB	_	28	advmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	translocation	translocation	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	several	several	JJ	JJ	_	37	amod	_	_
36	transcription	transcription	NN	NN	_	37	compound	_	_
37	factors	factor	NNS	NNS	_	33	nmod	_	_
38	,	,	,	,	_	37	punct	_	_
39	such	such	JJ	JJ	_	47	case	_	_
40	as	as	IN	IN	_	39	mwe	_	_
41	nuclear	nuclear	JJ	JJ	_	47	amod	_	_
42	factor	factor	NN	NN	_	47	compound	_	_
43	(	(	-LRB-	-LRB-	_	47	punct	_	_
44	NF	nf	NN	NN	_	47	compound	_	_
45	)	)	-RRB-	-RRB-	_	47	punct	_	_
46	-kappa	-kappa	NN	NN	_	47	compound	_	_
47	B	b	NN	NN	_	37	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	NF-AT	nf-at	NN	NN	_	47	conj	_	_
50	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	process	process	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	genes	gene	NNS	NNS	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	17	case	_	_
17	those	those	DT	DT	_	14	nmod	_	_
18	encoding	encode	VBG	VBG	_	17	acl	_	_
19	cytokines	cytokine	NNS	NNS	_	18	dobj	_	_
20	such	such	JJ	JJ	_	22	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	interleukin-2	interleukin-2	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	tumor	tumor	NN	NN	_	26	compound	_	_
25	necrosis	necrosis	NN	NN	_	26	compound	_	_
26	factor-alpha	factor-alpha	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	interferon	interferon	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	IFN	ifn	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	-gamma	-gamma	NN	NN	_	22	conj	_	_
34	which	which	WDT	WDT	_	35	nsubj	_	_
35	have	have	VBP	VBP	_	22	acl:relcl	_	_
36	important	important	JJ	JJ	_	38	amod	_	_
37	immunoregulatory	immunoregulatory	JJ	JJ	_	36	dep	_	_
38	effects	effect	NNS	NNS	_	35	dobj	_	_
39	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	11	nsubj	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	STAT1	stat1	NN	NN	_	8	dobj	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	becomes	become	VBZ	VBZ	_	2	ccomp	_	_
12	activated	activated	JJ	JJ	_	11	xcomp	_	_
13	in	in	IN	IN	_	18	case	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
16	blood	blood	NN	NN	_	18	compound	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Jurkat	jurkat	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	although	although	IN	IN	_	24	mark	_	_
24	not	not	RB	RB	_	11	advcl	_	_
25	until	until	IN	IN	_	27	case	_	_
26	1-2	1-2	CD	CD	_	27	nummod	_	_
27	h	h	NN	NN	_	24	nmod	_	_
28	after	after	IN	IN	_	29	case	_	_
29	stimulation	stimulation	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	delayed	delay	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	further	further	JJ	JJ	_	7	amod	_	_
6	1-2	1-2	CD	CD	_	7	nummod	_	_
7	hr	hr	NN	NN	_	3	dobj	_	_
8	when	when	WRB	WRB	_	13	advmod	_	_
9	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	cultures	culture	NNS	NNS	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	stimulated	stimulate	VBN	VBN	_	3	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	an	a	DT	DT	_	16	det	_	_
16	antigen	antigen	NN	NN	_	13	nmod	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	requires	require	VBZ	VBZ	_	16	acl:relcl	_	_
19	processing	processing	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Appearance	appearance	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	STAT1	stat1	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	reduced	reduce	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cyclosporin	cyclosporin	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	blocked	block	VBN	VBN	_	8	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	cycloheximide	cycloheximide	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	indicating	indicate	VBG	VBG	_	8	advcl	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	activation	activation	NN	NN	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	dependent	dependent	JJ	JJ	_	21	ccomp	_	_
27	upon	upon	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	protein	protein	NN	NN	_	31	compound	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	s	s	NNS	NNS	_	26	nmod	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	synthesized	synthesize	VBN	VBN	_	31	acl	_	_
34	in	in	IN	IN	_	35	case	_	_
35	response	response	NN	NN	_	33	nmod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	initial	initial	JJ	JJ	_	39	amod	_	_
38	signaling	signaling	NN	NN	_	39	compound	_	_
39	events	event	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	Neutralizing	neutralize	VBG	VBG	_	12	csubj	_	_
2	antiserum	antiserum	NN	NN	_	1	dobj	_	_
3	against	against	IN	IN	_	4	case	_	_
4	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	cytokines	cytokine	NNS	NNS	_	4	conj	_	_
10	tested	test	VBN	VBN	_	9	acl	_	_
11	,	,	,	,	_	1	punct	_	_
12	blocked	block	VBD	VBD	_	0	root	_	_
13	activation	activation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	factor	factor	NN	NN	_	13	nmod	_	_
17	almost	almost	RB	RB	_	18	advmod	_	_
18	completely	completely	RB	RB	_	12	advmod	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	found	find	VBN	VBN	_	12	conj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	culture	culture	NN	NN	_	27	compound	_	_
27	supernatants	supernatant	NNS	NNS	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	stimulated	stimulate	VBN	VBN	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	at	at	IN	IN	_	32	case	_	_
32	levels	level	NNS	NNS	_	30	nmod	_	_
33	at	at	IN	IN	_	34	case	_	_
34	which	which	WDT	WDT	_	38	nmod	_	_
35	recombinant	recombinant	JJ	JJ	_	36	amod	_	_
36	IFN-gamma	ifn-gamma	NN	NN	_	38	nsubj	_	_
37	could	could	MD	MD	_	38	aux	_	_
38	activate	activate	VB	VB	_	32	acl:relcl	_	_
39	the	the	DT	DT	_	40	det	_	_
40	factor	factor	NN	NN	_	38	dobj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	naive	naive	JJ	JJ	_	43	amod	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	12	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	STAT1	stat1	NN	NN	_	8	nsubjpass	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	4	dep	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	8	nmod	_	_
11	synthesized	synthesize	VBN	VBN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	released	release	VBN	VBN	_	11	conj	_	_
14	upon	upon	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	populations	population	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	secrete	secrete	VBP	VBP	_	16	advcl	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	respond	respond	VBP	VBP	_	5	conj	_	_
8	to	to	TO	TO	_	7	nmod	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	autocrine	autocrine	NN	NN	_	13	compound	_	_
13	loop	loop	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	seems	seem	VBZ	VBZ	_	0	root	_	_
17	likely	likely	JJ	JJ	_	16	xcomp	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	responding	respond	VBG	VBG	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	differ	differ	VB	VB	_	17	ccomp	_	_
24	from	from	IN	IN	_	25	case	_	_
25	those	those	DT	DT	_	23	nmod	_	_
26	synthesizing	synthesize	VBG	VBG	_	25	acl	_	_
27	this	this	DT	DT	_	28	det	_	_
28	cytokine	cytokine	NN	NN	_	26	dobj	_	_
29	in	in	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	mononuclear	mononuclear	JJ	JJ	_	33	amod	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	cultures	culture	NNS	NNS	_	26	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	light	light	NN	NN	_	23	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	recent	recent	JJ	JJ	_	40	amod	_	_
40	report	report	NN	NN	_	36	nmod	_	_
41	that	that	IN	IN	_	44	mark	_	_
42	Th1	th1	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	44	nsubj	_	_
44	lack	lack	VBP	VBP	_	40	ccomp	_	_
45	the	the	DT	DT	_	48	det	_	_
46	IFN-gamma	ifn-gamma	NN	NN	_	48	compound	_	_
47	receptor	receptor	NN	NN	_	48	compound	_	_
48	chain	chain	NN	NN	_	44	dobj	_	_
49	necessary	necessary	JJ	JJ	_	48	amod	_	_
50	for	for	IN	IN	_	51	case	_	_
51	activation	activation	NN	NN	_	49	nmod	_	_
52	of	of	IN	IN	_	53	case	_	_
53	STAT1	stat1	NN	NN	_	51	nmod	_	_
54	(	(	-LRB-	-LRB-	_	57	punct	_	_
55	Pernis	Pernis	NNP	NNP	_	57	compound	_	_
56	,	,	,	,	_	57	punct	_	_
57	A.	A.	NNP	NNP	_	40	dep	_	_
58	,	,	,	,	_	57	punct	_	_
59	Gupta	Gupta	NNP	NNP	_	61	compound	_	_
60	,	,	,	,	_	61	punct	_	_
61	S.	S.	NNP	NNP	_	57	conj	_	_
62	,	,	,	,	_	57	punct	_	_
63	Gollob	Gollob	NNP	NNP	_	65	compound	_	_
64	,	,	,	,	_	65	punct	_	_
65	K.J.	K.J.	NNP	NNP	_	57	conj	_	_
66	,	,	,	,	_	57	punct	_	_
67	Garfein	Garfein	NNP	NNP	_	69	compound	_	_
68	,	,	,	,	_	69	punct	_	_
69	E.	E.	NNP	NNP	_	57	conj	_	_
70	,	,	,	,	_	57	punct	_	_
71	Coffman	Coffman	NNP	NNP	_	73	compound	_	_
72	,	,	,	,	_	73	punct	_	_
73	R.L.	R.L.	NNP	NNP	_	57	conj	_	_
74	,	,	,	,	_	57	punct	_	_
75	Schindler	Schindler	NNP	NNP	_	77	compound	_	_
76	,	,	,	,	_	77	punct	_	_
77	C.	C.	NNP	NNP	_	57	conj	_	_
78	,	,	,	,	_	57	punct	_	_
79	and	and	CC	CC	_	57	cc	_	_
80	Rothman	Rothman	NNP	NNP	_	82	compound	_	_
81	,	,	,	,	_	82	punct	_	_
82	P.	P.	NNP	NNP	_	57	conj	_	_
83	,	,	,	,	_	57	punct	_	_
84	Science	Science	NNP	NNP	_	57	appos	_	_
85	1995	1995	CD	CD	_	84	nummod	_	_
86	.	.	.	.	_	57	punct	_	_
87	269	269	CD	CD	_	89	nummod	_	_
88	:	:	:	:	_	89	punct	_	_
89	245	245	CD	CD	_	57	dep	_	_
90	)	)	-RRB-	-RRB-	_	57	punct	_	_
91	.	.	.	.	_	16	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	model	model	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	latent	latent	JJ	JJ	_	7	amod	_	_
5	adenovirus	adenovirus	NN	NN	_	7	compound	_	_
6	5	5	CD	CD	_	7	nummod	_	_
7	infection	infection	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	guinea	guinea	NN	NN	_	11	compound	_	_
11	pig	pig	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	Cavia	cavia	NN	NN	_	14	compound	_	_
14	porcellus	porcellus	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	model	model	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	9	case	_	_
4	adenovirus	adenovirus	NN	NN	_	9	compound	_	_
5	5	5	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Ad5	ad5	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	infection	infection	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	developed	develop	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	guinea	guinea	NN	NN	_	14	compound	_	_
14	pigs	pig	NNS	NNS	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	begin	begin	VB	VB	_	11	xcomp	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	study	study	VB	VB	_	16	xcomp	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	role	role	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	pathogenesis	pathogenesis	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	peripheral	peripheral	JJ	JJ	_	27	amod	_	_
26	lung	lung	NN	NN	_	27	compound	_	_
27	inflammation	inflammation	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Forty	forty	CD	CD	_	2	nummod	_	_
2	animals	animal	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	inoculated	inoculate	VBN	VBN	_	0	root	_	_
5	intranasally	intranasally	RB	RB	_	4	advmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	10(7.0)	10(7.0)	CD	CD	_	8	nummod	_	_
8	pfu	pfu	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Ad5/animal	ad5/animal	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	15	15	CD	CD	_	14	nummod	_	_
14	animals	animal	NNS	NNS	_	15	nsubj	_	_
15	inoculated	inoculate	VBN	VBN	_	4	conj	_	_
16	with	with	IN	IN	_	19	case	_	_
17	sterile	sterile	JJ	JJ	_	19	amod	_	_
18	culture	culture	NN	NN	_	19	compound	_	_
19	media	media	NNS	NNS	_	15	nmod	_	_
20	served	serve	VBD	VBD	_	19	acl	_	_
21	as	as	IN	IN	_	22	case	_	_
22	controls	control	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Viral	viral	JJ	JJ	_	2	amod	_	_
2	titres	titre	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	10(4.4)	10(4.4)	CD	CD	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	10(6.1)	10(6.1)	CD	CD	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	10(5.2)	10(5.2)	CD	CD	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	10(2.9)	10(2.9)	CD	CD	_	4	conj	_	_
12	pfu/animal	pfu/animal	NN	NN	_	4	dep	_	_
13	,	,	,	,	_	4	punct	_	_
14	on	on	IN	IN	_	15	case	_	_
15	days	day	NNS	NNS	_	4	nmod	_	_
16	1	1	CD	CD	_	15	dep	_	_
17	,	,	,	,	_	15	punct	_	_
18	3	3	CD	CD	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	4	4	CD	CD	_	15	conj	_	_
21	,	,	,	,	_	15	punct	_	_
22	and	and	CC	CC	_	15	cc	_	_
23	7	7	CD	CD	_	15	conj	_	_
24	after	after	IN	IN	_	25	case	_	_
25	infection	infection	NN	NN	_	15	nmod	_	_
26	,	,	,	,	_	4	punct	_	_
27	respectively	respectively	RB	RB	_	4	advmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	hybridization	hybridization	NN	NN	_	13	nsubj	_	_
4	to	to	TO	TO	_	6	case	_	_
5	viral	viral	JJ	JJ	_	6	amod	_	_
6	DNA	dna	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	immunocytochemistry	immunocytochemistry	NN	NN	_	3	conj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	Ad5	ad5	NN	NN	_	8	nmod	_	_
11	E1A	e1a	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	10	dep	_	_
13	localized	localize	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	virus	virus	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	airway	airway	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	alveolar	alveolar	JJ	JJ	_	21	amod	_	_
20	epithelial	epithelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	13	punct	_	_

1	Histologic	histologic	JJ	JJ	_	2	amod	_	_
2	examination	examination	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	8	det	_	_
5	extensive	extensive	JJ	JJ	_	8	amod	_	_
6	inflammatory	inflammatory	JJ	JJ	_	5	dep	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	infiltration	infiltration	NN	NN	_	3	dobj	_	_
9	around	around	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	airways	airway	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	with	with	IN	IN	_	15	case	_	_
14	epithelial	epithelial	JJ	JJ	_	15	amod	_	_
15	necrosis	necrosis	NN	NN	_	3	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	an	a	DT	DT	_	19	det	_	_
18	alveolar	alveolar	JJ	JJ	_	19	amod	_	_
19	exudate	exudate	NN	NN	_	15	conj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	caused	cause	VBD	VBD	_	19	acl:relcl	_	_
22	localized	localized	JJ	JJ	_	24	amod	_	_
23	alveolar	alveolar	JJ	JJ	_	24	amod	_	_
24	collapse	collapse	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	infected	infected	JJ	JJ	_	28	amod	_	_
28	areas	area	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Immunocytochemistry	immunocytochemistry	NN	NN	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	infiltrate	infiltrate	NN	NN	_	4	nmod	_	_
8	as	as	IN	IN	_	11	case	_	_
9	cytotoxic	cytotoxic	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	11	mark	_	_
2	all	all	DT	DT	_	3	det	_	_
3	animals	animal	NNS	NNS	_	11	nsubj	_	_
4	20	20	CD	CD	_	7	nummod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	47	47	CD	CD	_	4	conj	_	_
7	days	day	NNS	NNS	_	3	nmod	_	_
8	after	after	IN	IN	_	7	case	_	_
9	infection	infection	NN	NN	_	7	dep	_	_
10	had	have	VBD	VBD	_	11	aux	_	_
11	seroconverted	seroconvert	VBN	VBN	_	18	advcl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	Ad5	ad5	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	virus	virus	NN	NN	_	18	nsubjpass	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	detected	detect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	groups	group	NNS	NNS	_	18	nmod	_	_
22	either	either	CC	CC	_	18	dep	_	_
23	by	by	IN	IN	_	26	case	_	_
24	viral	viral	JJ	JJ	_	26	amod	_	_
25	plaque	plaque	NN	NN	_	26	compound	_	_
26	assay	assay	NN	NN	_	18	conj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	in	in	FW	FW	_	30	amod	_	_
29	situ	situ	FW	FW	_	28	dep	_	_
30	hybridization	hybridization	NN	NN	_	26	conj	_	_
31	.	.	.	.	_	18	punct	_	_

1	Ad5	ad5	NN	NN	_	3	compound	_	_
2	E1A	e1a	NN	NN	_	3	compound	_	_
3	DNA	dna	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	polymerase	polymerase	NN	NN	_	9	compound	_	_
8	chain	chain	NN	NN	_	9	compound	_	_
9	reaction	reaction	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	five	five	CD	CD	_	16	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	six	six	CD	CD	_	14	nummod	_	_
14	animals	animal	NNS	NNS	_	11	nmod	_	_
15	20	20	CD	CD	_	16	nummod	_	_
16	days	day	NNS	NNS	_	5	nmod	_	_
17	after	after	IN	IN	_	18	case	_	_
18	infection	infection	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	in	in	IN	IN	_	21	case	_	_
21	five	five	CD	CD	_	16	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	five	five	CD	CD	_	24	nummod	_	_
24	animals	animal	NNS	NNS	_	21	nmod	_	_
25	47	47	CD	CD	_	26	nummod	_	_
26	days	day	NNS	NNS	_	16	dep	_	_
27	after	after	IN	IN	_	28	case	_	_
28	infection	infection	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	these	these	DT	DT	_	4	det	_	_
3	same	same	JJ	JJ	_	4	amod	_	_
4	animals	animal	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	E1A	e1a	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	detected	detect	VBN	VBN	_	0	root	_	_
10	20	20	CD	CD	_	11	nummod	_	_
11	days	day	NNS	NNS	_	9	dobj	_	_
12	after	after	IN	IN	_	13	case	_	_
13	infection	infection	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	two	two	CD	CD	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	47	47	CD	CD	_	18	nummod	_	_
18	days	day	NNS	NNS	_	9	conj	_	_
19	after	after	IN	IN	_	20	case	_	_
20	infection	infection	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	one	one	CD	CD	_	9	nmod	_	_
23	while	while	IN	IN	_	27	mark	_	_
24	persistent	persistent	JJ	JJ	_	25	amod	_	_
25	bronchiolitis	bronchiolitis	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	observed	observe	VBN	VBN	_	9	advcl	_	_
28	in	in	IN	IN	_	29	case	_	_
29	four	four	CD	CD	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	three	three	CD	CD	_	29	conj	_	_
32	animals	animal	NNS	NNS	_	29	dep	_	_
33	20	20	CD	CD	_	27	dobj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	47	47	CD	CD	_	33	conj	_	_
36	days	day	NNS	NNS	_	33	dep	_	_
37	after	after	IN	IN	_	38	case	_	_
38	infection	infection	NN	NN	_	33	nmod	_	_
39	,	,	,	,	_	27	punct	_	_
40	respectively	respectively	RB	RB	_	27	advmod	_	_
41	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	guinea	guinea	NN	NN	_	7	compound	_	_
7	pig	pig	NN	NN	_	8	nsubj	_	_
8	provides	provide	VBZ	VBZ	_	3	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	useful	useful	JJ	JJ	_	11	amod	_	_
11	model	model	NN	NN	_	8	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	study	study	VB	VB	_	11	acl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	role	role	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Ad5	ad5	NN	NN	_	18	compound	_	_
18	infection	infection	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	chronic	chronic	JJ	JJ	_	22	amod	_	_
21	airway	airway	NN	NN	_	22	compound	_	_
22	inflammation	inflammation	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Herpesvirus	herpesvirus	NN	NN	_	8	compound	_	_
2	saimiri	saimiri	NN	NN	_	8	compound	_	_
3	immortalized	immortalize	VBD	VBD	_	8	amod	_	_
4	gamma	gamma	NN	NN	_	8	compound	_	_
5	delta	delta	NN	NN	_	8	compound	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	0	root	_	_
9	activated	activate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IL-12	il-12	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	IL-12	il-12	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	heterodimeric	heterodimeric	JJ	JJ	_	6	amod	_	_
6	cytokine	cytokine	NN	NN	_	0	root	_	_
7	important	important	JJ	JJ	_	6	amod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	differentiation	differentiation	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NK	nk	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Like	like	IN	IN	_	3	case	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	IL-12	il-12	NN	NN	_	6	nsubj	_	_
6	mediates	mediate	VBZ	VBZ	_	0	root	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	biologic	biologic	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	through	through	IN	IN	_	12	case	_	_
11	high-affinity	high-affinity	JJ	JJ	_	12	amod	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	expressed	express	VBN	VBN	_	12	acl	_	_
14	on	on	IN	IN	_	16	case	_	_
15	responsive	responsive	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	case	_	_
2	date	date	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	large	large	JJ	JJ	_	6	amod	_	_
6	number	number	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	receptors	receptor	NNS	NNS	_	6	nmod	_	_
9	for	for	IN	IN	_	10	case	_	_
10	IL-12	il-12	NN	NN	_	8	nmod	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	only	only	RB	RB	_	16	advmod	_	_
15	on	on	IN	IN	_	16	case	_	_
16	PBMC	pbmc	NN	NN	_	13	nmod	_	_
17	following	follow	VBG	VBG	_	18	case	_	_
18	activation	activation	NN	NN	_	13	nmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	PHA	pha	NN	NN	_	18	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	IL-2	il-2	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	0	root	_	_
3	further	further	JJ	JJ	_	4	amod	_	_
4	knowledge	knowledge	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-12R	il-12r	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	14	det	_	_
11	IL-12	il-12	NN	NN	_	14	compound	_	_
12	signal	signal	NN	NN	_	14	compound	_	_
13	transduction	transduction	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	8	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	cytotoxic	cytotoxic	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	studied	study	VBD	VBD	_	2	parataxis	_	_
22	a	a	DT	DT	_	23	det	_	_
23	number	number	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	23	nmod	_	_
29	that	that	WDT	WDT	_	32	nsubjpass	_	_
30	had	have	VBD	VBD	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	transformed	transform	VBN	VBN	_	28	acl:relcl	_	_
33	to	to	TO	TO	_	35	case	_	_
34	permanent	permanent	JJ	JJ	_	35	amod	_	_
35	growth	growth	NN	NN	_	32	nmod	_	_
36	with	with	IN	IN	_	38	case	_	_
37	Herpesvirus	herpesvirus	NN	NN	_	38	compound	_	_
38	saimiri	saimiri	NN	NN	_	35	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	an	a	DT	DT	_	42	det	_	_
41	oncogenic	oncogenic	JJ	JJ	_	42	amod	_	_
42	virus	virus	NN	NN	_	38	appos	_	_
43	of	of	IN	IN	_	45	case	_	_
44	nonhuman	nonhuman	JJ	JJ	_	45	amod	_	_
45	primates	primate	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	reports	report	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-12R	il-12r	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	15	case	_	_
9	a	a	DT	DT	_	15	det	_	_
10	human	human	JJ	JJ	_	15	amod	_	_
11	gamma	gamma	NN	NN	_	15	compound	_	_
12	delta	delta	NN	NN	_	15	compound	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	5	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	responds	respond	VBZ	VBZ	_	15	acl:relcl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	IL-12	il-12	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	enhanced	enhance	VBN	VBN	_	23	amod	_	_
22	cytolytic	cytolytic	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	increased	increase	VBN	VBN	_	26	amod	_	_
26	expression	expression	NN	NN	_	23	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	cytolytic	cytolytic	JJ	JJ	_	30	amod	_	_
29	effector	effector	NN	NN	_	30	compound	_	_
30	molecules	molecule	NNS	NNS	_	26	nmod	_	_
31	granzyme	granzyme	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	30	dep	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	perforin	perforin	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	these	these	DT	DT	_	4	det	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	model	model	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	IL-12	il-12	NN	NN	_	11	compound	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	confirmed	confirm	VBD	VBD	_	1	parataxis	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	these	these	DT	DT	_	17	det	_	_
17	events	event	NNS	NNS	_	18	nsubj	_	_
18	involve	involve	VBP	VBP	_	14	ccomp	_	_
19	members	member	NNS	NNS	_	18	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	Janus	janus	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	nonreceptor	nonreceptor	NN	NN	_	28	compound	_	_
27	tyrosine	tyrosine	NN	NN	_	28	compound	_	_
28	kinases	kinase	NNS	NNS	_	24	nmod	_	_
29	JAK2	jak2	NN	NN	_	19	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	TYK2	tyk2	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	signal	signal	NN	NN	_	35	compound	_	_
35	transducer	transducer	NN	NN	_	29	conj	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	activator	activator	NN	NN	_	39	compound	_	_
38	of	of	IN	IN	_	39	amod	_	_
39	transcription	transcription	NN	NN	_	35	conj	_	_
40	4	4	CD	CD	_	39	nummod	_	_
41	.	.	.	.	_	1	punct	_	_

1	IL-13	il-13	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	activation	activation	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	JAK2	jak2	NN	NN	_	9	compound	_	_
8	Janus	janus	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	human	human	JJ	JJ	_	15	amod	_	_
12	colon	colon	NN	NN	_	15	compound	_	_
13	carcinoma	carcinoma	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	2	nmod	_	_
16	:	:	:	:	_	2	punct	_	_
17	similarities	similarity	NNS	NNS	_	2	dep	_	_
18	between	between	IN	IN	_	22	case	_	_
19	IL-4	il-4	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-13	il-13	NN	NN	_	19	conj	_	_
22	signaling	signaling	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	IL-13R	il-13r	NN	NN	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	share	share	VB	VB	_	4	ccomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	component	component	NN	NN	_	8	dobj	_	_
11	with	with	IN	IN	_	12	case	_	_
12	IL-4R	il-4r	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	IL-4	il-4	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-13	il-13	NN	NN	_	6	conj	_	_
9	share	share	VBP	VBP	_	3	ccomp	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	events	event	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	colon	colon	NN	NN	_	17	compound	_	_
15	carcinoma	carcinoma	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	11	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HT-29	ht-29	NN	NN	_	17	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	WiDr	widr	NN	NN	_	19	conj	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	IL-13	il-13	NN	NN	_	2	nsubj	_	_
2	caused	cause	VBD	VBD	_	0	root	_	_
3	rapid	rapid	JJ	JJ	_	4	amod	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	three	three	CD	CD	_	10	compound	_	_
8	out	out	IN	IN	_	10	advmod	_	_
9	of	of	IN	IN	_	10	advmod	_	_
10	four	four	CD	CD	_	11	nummod	_	_
11	members	member	NNS	NNS	_	4	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	known	known	JJ	JJ	_	16	amod	_	_
15	Janus	janus	NN	NN	_	16	compound	_	_
16	family	family	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	kinases	kinase	NNS	NNS	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	JAKs	jak	NNS	NNS	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	JAK2	jak2	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	8	nsubj	_	_
6	is	be	VBZ	VBZ	_	8	aux	_	_
7	rapidly	rapidly	RB	RB	_	8	advmod	_	_
8	phosphorylated	phosphorylate	VBN	VBN	_	2	ccomp	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	activated	activate	VBN	VBN	_	8	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	response	response	NN	NN	_	14	dep	_	_
13	to	to	TO	TO	_	14	case	_	_
14	IL-13	il-13	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	1	1	CD	CD	_	3	nummod	_	_
3	min	min	NN	NN	_	9	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	activation	activation	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	JAK2	jak2	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	peaked	peak	VBD	VBD	_	9	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	10	10	CD	CD	_	15	nummod	_	_
15	min	min	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IL-13	il-13	NN	NN	_	5	nsubj	_	_
5	phosphorylated	phosphorylate	VBD	VBD	_	0	root	_	_
6	insulin	insulin	NN	NN	_	8	compound	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	substrate-1	substrate-1	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	IL-4R	il-4r	NN	NN	_	11	compound	_	_
11	p140	p140	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	JAK1	jak1	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	8	punct	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	Tyk2	tyk2	NN	NN	_	8	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	8	cc	_	_
20	JAK3	jak3	NN	NN	_	21	compound	_	_
21	kinase	kinase	NN	NN	_	8	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	IL-4	il-4	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	stimulated	stimulate	VBD	VBD	_	0	root	_	_
4	all	all	DT	DT	_	5	advmod	_	_
5	three	three	CD	CD	_	6	nummod	_	_
6	kinases	kinase	NNS	NNS	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	substrates	substrate	NNS	NNS	_	6	conj	_	_
9	,	,	,	,	_	3	punct	_	_
10	but	but	CC	CC	_	3	cc	_	_
11	unlike	unlike	IN	IN	_	14	case	_	_
12	in	in	IN	IN	_	14	case	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	19	advcl	_	_
15	,	,	,	,	_	19	punct	_	_
16	IL-4	il-4	NN	NN	_	19	nsubj	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	involve	involve	VB	VB	_	3	conj	_	_
20	JAK3	jak3	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	for	for	IN	IN	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	signaling	signaling	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	colon	colon	NN	NN	_	29	compound	_	_
27	cancer	cancer	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	JAK2	jak2	NN	NN	_	4	nsubj	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-4R	il-4r	NN	NN	_	8	compound	_	_
8	p140	p140	NN	NN	_	4	nmod	_	_
9	before	before	IN	IN	_	12	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	after	after	IN	IN	_	9	conj	_	_
12	stimulation	stimulation	NN	NN	_	4	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	IL-13	il-13	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	IL-13	il-13	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-4	il-4	NN	NN	_	2	conj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	IL-4	il-4	NN	NN	_	9	compound	_	_
9	STAT	stat	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	STAT6	stat6	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	9	cc	_	_
15	STAT1	stat1	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	15	punct	_	_
17	STAT3	stat3	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	or	or	CC	CC	_	15	cc	_	_
20	STAT5	stat5	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	125I-IL-13	125i-il-13	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	bind	bind	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	9	case	_	_
6	colon	colon	NN	NN	_	9	compound	_	_
7	cancer	cancer	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	but	but	CC	CC	_	4	cc	_	_
12	unlabeled	unlabeled	JJ	JJ	_	13	amod	_	_
13	IL-13	il-13	NN	NN	_	14	nsubj	_	_
14	competed	compete	VBD	VBD	_	4	conj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	binding	binding	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	125I-IL-4	125i-il-4	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IL-13	il-13	NN	NN	_	6	nsubj	_	_
6	utilizes	utilize	VBZ	VBZ	_	3	ccomp	_	_
7	IL-4R	il-4r	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	JAK2	jak2	NN	NN	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	play	play	VB	VB	_	6	conj	_	_
17	an	a	DT	DT	_	19	det	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	function	function	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IL-4R	il-4r	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	IL-13R	il-13r	NN	NN	_	24	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	colon	colon	NN	NN	_	30	compound	_	_
29	cancer	cancer	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	22	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p23	p23	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	hsp90	hsp90	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	immunophilins	immunophilin	NNS	NNS	_	4	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	assembly	assembly	NN	NN	_	2	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	progesterone	progesterone	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	complexes	complex	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	assembly	assembly	NN	NN	_	6	compound	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	progesterone	progesterone	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PR	pr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	3	punct	_	_
15	we	we	PRP	PRP	_	17	nsubj	_	_
16	have	have	VBP	VBP	_	17	aux	_	_
17	developed	develop	VBN	VBN	_	3	parataxis	_	_
18	cell-free	cell-free	JJ	JJ	_	19	amod	_	_
19	systems	system	NNS	NNS	_	17	dobj	_	_
20	for	for	IN	IN	_	21	mark	_	_
21	studying	study	VBG	VBG	_	19	acl	_	_
22	interactions	interaction	NNS	NNS	_	21	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	PR	pr	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	hsp90	hsp90	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	other	other	JJ	JJ	_	31	amod	_	_
30	associated	associate	VBN	VBN	_	31	amod	_	_
31	proteins	protein	NNS	NNS	_	24	conj	_	_
32	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	PR	pr	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	incubated	incubate	VBN	VBN	_	30	advcl	_	_
5	in	in	IN	IN	_	8	case	_	_
6	rabbit	rabbit	NN	NN	_	8	compound	_	_
7	reticulocyte	reticulocyte	NN	NN	_	8	compound	_	_
8	lysate	lysate	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	30	punct	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	association	association	NN	NN	_	30	nsubjpass	_	_
12	with	with	IN	IN	_	13	case	_	_
13	hsp90	hsp90	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	hsp70	hsp70	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	three	three	CD	CD	_	19	nummod	_	_
19	immunophilins	immunophilins	JJ	JJ	_	13	appos	_	_
20	FKBP54	fkbp54	NN	NN	_	19	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	FKBP52	fkbp52	NN	NN	_	20	conj	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	CyP-40	cyp-40	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	13	punct	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	with	with	IN	IN	_	28	case	_	_
28	p23	p23	NN	NN	_	13	conj	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	observed	observe	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	interactions	interaction	NNS	NNS	_	3	nsubj	_	_
3	require	require	VBP	VBP	_	0	root	_	_
4	ATP/Mg2+	atp/mg2+	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	when	when	WRB	WRB	_	9	advmod	_	_
7	ATP	atp	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	aux	_	_
9	limiting	limit	VBG	VBG	_	14	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	PR	pr	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	altered	alter	VBN	VBN	_	3	conj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	one	one	CD	CD	_	14	nmod	_	_
17	containing	contain	VBG	VBG	_	16	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	proteins	protein	NNS	NNS	_	17	dobj	_	_
20	p60	p60	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	p48	p48	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	17	punct	_	_
24	but	but	CC	CC	_	17	cc	_	_
25	lacking	lack	VBG	VBG	_	17	conj	_	_
26	immunophilins	immunophilin	NNS	NNS	_	25	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	p23	p23	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	two	two	CD	CD	_	7	nummod	_	_
5	pre-formed	pre-formed	JJ	JJ	_	7	amod	_	_
6	hsp90	hsp90	NN	NN	_	7	compound	_	_
7	complexes	complex	NNS	NNS	_	3	dobj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	participate	participate	VB	VB	_	7	acl:relcl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	assembly	assembly	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	PR	pr	NN	NN	_	16	compound	_	_
16	complexes	complex	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	hsp90	hsp90	NN	NN	_	2	dobj	_	_
4	bound	bind	VBN	VBN	_	3	acl	_	_
5	to	to	TO	TO	_	6	case	_	_
6	hsp70	hsp70	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p60	p60	NN	NN	_	6	conj	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	this	this	DT	DT	_	11	det	_	_
11	complex	complex	NN	NN	_	12	nsubj	_	_
12	forms	form	VBZ	VBZ	_	2	conj	_	_
13	spontaneously	spontaneously	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	absence	absence	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	ATP	atp	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	hsp90	hsp90	NN	NN	_	4	dobj	_	_
6	bound	bind	VBN	VBN	_	5	acl	_	_
7	to	to	TO	TO	_	8	case	_	_
8	p23	p23	NN	NN	_	6	nmod	_	_
9	plus	plus	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	three	three	CD	CD	_	12	nummod	_	_
12	immunophilins	immunophilin	NNS	NNS	_	8	conj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	some	some	DT	DT	_	15	det	_	_
15	hsp70	hsp70	NN	NN	_	8	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	formation	formation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	complex	complex	NN	NN	_	2	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	ATP	atp	NN	NN	_	6	dobj	_	_
8	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	further	further	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	purified	purify	VBN	VBN	_	9	amod	_	_
9	hsp90	hsp90	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	bind	bind	VB	VB	_	6	dep	_	_
12	to	to	TO	TO	_	14	case	_	_
13	purified	purify	VBN	VBN	_	14	amod	_	_
14	p23	p23	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	this	this	DT	DT	_	17	det	_	_
17	interaction	interaction	NN	NN	_	18	nsubj	_	_
18	requires	require	VBZ	VBZ	_	11	conj	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	ATP	atp	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	molybdate	molybdate	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	explains	explain	VBZ	VBZ	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	in	in	IN	IN	_	5	case	_	_
5	part	part	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	known	known	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	2	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	ATP	atp	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	molybdate	molybdate	NN	NN	_	11	conj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	assembly	assembly	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	PR	pr	NN	NN	_	18	compound	_	_
18	complexes	complex	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Coexpression	coexpression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	interleukin-13	interleukin-13	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	interleukin-4	interleukin-4	NN	NN	_	4	conj	_	_
7	genes	gene	NNS	NNS	_	4	dep	_	_
8	correlates	correlate	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	physical	physical	JJ	JJ	_	12	amod	_	_
12	linkage	linkage	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	cytokine	cytokine	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	cluster	cluster	NN	NN	_	12	nmod	_	_
18	on	on	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	chromosome	chromosome	NN	NN	_	21	compound	_	_
21	5q23-31	5q23-31	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Interleukin-13	interleukin-13	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-13	il-13	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	IL-4	il-4	NN	NN	_	1	conj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	cytokines	cytokine	NNS	NNS	_	0	root	_	_
9	produced	produce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	encoded	encode	VBN	VBN	_	12	acl:relcl	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	q23-31	q23-31	NN	NN	_	19	compound	_	_
19	region	region	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	chromosome	chromosome	NN	NN	_	19	nmod	_	_
23	5	5	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-13	il-13	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	isolated	isolate	VBD	VBD	_	2	parataxis	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	sequenced	sequence	VBD	VBD	_	14	conj	_	_
17	the	the	DT	DT	_	20	det	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	IL-13	il-13	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	14	dobj	_	_
21	,	,	,	,	_	14	punct	_	_
22	analyzed	analyze	VBD	VBD	_	14	conj	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	5'-flanking	5'-flanking	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	30	case	_	_
27	potential	potential	JJ	JJ	_	30	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
29	activation	activation	NN	NN	_	30	compound	_	_
30	elements	element	NNS	NNS	_	25	nmod	_	_
31	,	,	,	,	_	14	punct	_	_
32	and	and	CC	CC	_	14	cc	_	_
33	examined	examine	VBD	VBD	_	14	conj	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	expression	expression	NN	NN	_	33	dobj	_	_
36	in	in	IN	IN	_	40	case	_	_
37	nontransformed	nontransformed	JJ	JJ	_	40	amod	_	_
38	T-lineage	t-lineage	NN	NN	_	40	compound	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	populations	population	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	IL-13	il-13	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	located	located	JJ	JJ	_	0	root	_	_
7	12.5-kb	12.5-kb	JJ	JJ	_	6	dep	_	_
8	upstream	upstream	RB	RB	_	7	advmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-4	il-4	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	2-kb	2-kb	JJ	JJ	_	7	conj	_	_
15	downstream	downstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	CpG	cpg	NN	NN	_	19	compound	_	_
19	island	island	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	IL-13	il-13	NN	NN	_	6	compound	_	_
3	gene	gene	NN	NN	_	6	compound	_	_
4	5'	5'	JJ	JJ	_	6	amod	_	_
5	flank	flank	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	7	nsubj	_	_
7	included	include	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	segment	segment	NN	NN	_	7	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	sequence	sequence	NN	NN	_	12	compound	_	_
12	homology	homology	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	P	p	NN	NN	_	15	compound	_	_
15	elements	element	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-4	il-4	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	involved	involve	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Mutation	mutation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	IL-13	il-13	NN	NN	_	7	compound	_	_
5	P	p	NN	NN	_	7	compound	_	_
6	element	element	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	1	nmod	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	IL-13	il-13	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Oligonucleotides	oligonucleotide	NNS	NNS	_	11	nsubj	_	_
2	containing	contain	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	IL-13	il-13	NN	NN	_	2	dobj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	IL-4	il-4	NN	NN	_	9	compound	_	_
7	P	p	NN	NN	_	9	compound	_	_
8	element	element	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	4	conj	_	_
10	specifically	specifically	RB	RB	_	11	advmod	_	_
11	bound	bind	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
14	activator	activator	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	11	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
18	factor-activated	factor-activated	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	appos	_	_
21	,	,	,	,	_	15	punct	_	_
22	preformed	preformed	JJ	JJ	_	15	appos	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	NF-ATp	nf-atp	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	11	punct	_	_
27	when	when	WRB	WRB	_	28	advmod	_	_
28	incubated	incubate	VBN	VBN	_	11	advcl	_	_
29	with	with	IN	IN	_	32	case	_	_
30	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
31	protein	protein	NN	NN	_	32	compound	_	_
32	extracts	extract	NNS	NNS	_	28	nmod	_	_
33	from	from	IN	IN	_	36	case	_	_
34	activated	activate	VBN	VBN	_	36	amod	_	_
35	T	t	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	Similar	similar	JJ	JJ	_	9	advmod	_	_
2	to	to	TO	TO	_	3	case	_	_
3	IL-4	il-4	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	IL-13	il-13	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	highest	highest	JJS	JJS	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	populations	population	NNS	NNS	_	9	nmod	_	_
13	enriched	enrich	VBN	VBN	_	12	acl	_	_
14	for	for	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	13	nmod	_	_
16	that	that	WDT	WDT	_	20	nsubjpass	_	_
17	had	have	VBD	VBD	_	20	aux	_	_
18	previously	previously	RB	RB	_	20	advmod	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	primed	prime	VBN	VBN	_	15	acl:relcl	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	23	advmod	_	_
23	or	or	CC	CC	_	20	advmod	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vitro	vitro	FW	FW	_	23	advmod	_	_
26	,	,	,	,	_	9	punct	_	_
27	indicating	indicate	VBG	VBG	_	9	xcomp	_	_
28	that	that	IN	IN	_	30	mark	_	_
29	priming	priming	NN	NN	_	30	nsubj	_	_
30	increases	increase	VBZ	VBZ	_	27	ccomp	_	_
31	the	the	DT	DT	_	32	det	_	_
32	expression	expression	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	dep	_	_
35	IL-13	il-13	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	IL-4	il-4	NN	NN	_	35	conj	_	_
38	genes	gene	NNS	NNS	_	35	dep	_	_
39	in	in	IN	IN	_	42	case	_	_
40	a	a	DT	DT	_	42	det	_	_
41	coordinate	coordinate	JJ	JJ	_	42	amod	_	_
42	manner	manner	NN	NN	_	30	nmod	_	_
43	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	primed	prime	VBN	VBN	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	contain	contain	VBP	VBP	_	38	advcl	_	_
7	higher	higher	JJR	JJR	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	NF-ATp	nf-atp	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	capable	capable	JJ	JJ	_	11	amod	_	_
14	of	of	IN	IN	_	15	mark	_	_
15	binding	bind	VBG	VBG	_	13	advcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	P	p	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	IL-4	il-4	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-13	il-13	NN	NN	_	21	conj	_	_
24	promoters	promoter	NNS	NNS	_	21	dep	_	_
25	,	,	,	,	_	8	punct	_	_
26	than	than	IN	IN	_	27	dep	_	_
27	do	do	VBP	VBP	_	8	dep	_	_
28	freshly-isolated	freshly-isolated	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nsubj	_	_
31	,	,	,	,	_	38	punct	_	_
32	the	the	DT	DT	_	35	det	_	_
33	NF-AT-binding	nf-at-binding	JJ	JJ	_	35	amod	_	_
34	P	p	NN	NN	_	35	compound	_	_
35	elements	element	NNS	NNS	_	38	nsubj	_	_
36	are	be	VBP	VBP	_	38	cop	_	_
37	attractive	attractive	JJ	JJ	_	38	amod	_	_
38	candidates	candidate	NNS	NNS	_	0	root	_	_
39	to	to	TO	TO	_	40	mark	_	_
40	mediate	mediate	VB	VB	_	38	acl	_	_
41	the	the	DT	DT	_	43	det	_	_
42	coordinate	coordinate	JJ	JJ	_	43	amod	_	_
43	expression	expression	NN	NN	_	40	dobj	_	_
44	of	of	IN	IN	_	48	case	_	_
45	these	these	DT	DT	_	48	det	_	_
46	two	two	CD	CD	_	48	nummod	_	_
47	cytokine	cytokine	NN	NN	_	48	compound	_	_
48	genes	gene	NNS	NNS	_	43	nmod	_	_
49	.	.	.	.	_	38	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	mammalian	mammalian	JJ	JJ	_	4	amod	_	_
3	histone	histone	NN	NN	_	4	compound	_	_
4	deacetylase	deacetylase	NN	NN	_	0	root	_	_
5	related	related	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	yeast	yeast	NN	NN	_	10	compound	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	5	nmod	_	_
11	Rpd3p	rpd3p	NN	NN	_	10	dep	_	_
12	-LSB-	-lsb-	-LRB-	-LRB-	_	13	punct	_	_
13	see	see	VB	VB	_	4	dep	_	_
14	comments	comment	NNS	NNS	_	13	dobj	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	13	punct	_	_

1	Trapoxin	trapoxin	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	microbially	microbially	RB	RB	_	5	advmod	_	_
5	derived	derive	VBN	VBN	_	6	amod	_	_
6	cyclotetrapeptide	cyclotetrapeptide	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	inhibits	inhibit	VBZ	VBZ	_	6	acl:relcl	_	_
9	histone	histone	NN	NN	_	10	compound	_	_
10	deacetylation	deacetylation	NN	NN	_	8	dobj	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	8	advmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	causes	cause	VBZ	VBZ	_	8	conj	_	_
15	mammalian	mammalian	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	14	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	arrest	arrest	VB	VB	_	14	xcomp	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	cycle	cycle	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	trapoxin	trapoxin	NN	NN	_	4	compound	_	_
3	affinity	affinity	NN	NN	_	4	compound	_	_
4	matrix	matrix	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	isolate	isolate	VB	VB	_	6	xcomp	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	copurified	copurify	VBD	VBD	_	11	acl:relcl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	histone	histone	NN	NN	_	16	compound	_	_
16	deacetylase	deacetylase	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	peptide	peptide	NN	NN	_	7	compound	_	_
7	microsequencing	microsequencing	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	a	a	DT	DT	_	12	det	_	_
11	complementary	complementary	JJ	JJ	_	12	amod	_	_
12	DNA	dna	NN	NN	_	23	nsubjpass	_	_
13	encoding	encode	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	18	det	_	_
15	histone	histone	NN	NN	_	18	compound	_	_
16	deacetylase	deacetylase	NN	NN	_	18	compound	_	_
17	catalytic	catalytic	JJ	JJ	_	18	amod	_	_
18	subunit	subunit	NN	NN	_	13	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HD1	hd1	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	cloned	clone	VBN	VBN	_	4	conj	_	_
24	from	from	IN	IN	_	30	case	_	_
25	a	a	DT	DT	_	30	det	_	_
26	human	human	JJ	JJ	_	30	amod	_	_
27	Jurkat	jurkat	NN	NN	_	30	compound	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	library	library	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	predicted	predict	VBN	VBN	_	4	amod	_	_
4	protein	protein	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	very	very	RB	RB	_	7	advmod	_	_
7	similar	similar	JJ	JJ	_	17	advcl	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	yeast	yeast	NN	NN	_	12	compound	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	regulator	regulator	NN	NN	_	7	nmod	_	_
13	Rpd3p	rpd3p	NN	NN	_	12	dep	_	_
14	,	,	,	,	_	17	punct	_	_
15	these	these	DT	DT	_	16	det	_	_
16	results	result	NNS	NNS	_	17	nsubj	_	_
17	support	support	VBP	VBP	_	0	root	_	_
18	a	a	DT	DT	_	19	det	_	_
19	role	role	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	histone	histone	NN	NN	_	22	compound	_	_
22	deacetylase	deacetylase	NN	NN	_	19	nmod	_	_
23	as	as	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	key	key	JJ	JJ	_	26	amod	_	_
26	regulator	regulator	NN	NN	_	19	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	eukaryotic	eukaryotic	JJ	JJ	_	29	amod	_	_
29	transcription	transcription	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	interleukin-10	interleukin-10	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	10	case	_	_
5	human	human	JJ	JJ	_	10	amod	_	_
6	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
7	blood	blood	NN	NN	_	10	compound	_	_
8	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	1	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	Cryptococcus	cryptococcus	NN	NN	_	13	compound	_	_
13	neoformans	neoforman	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	Candida	candida	NN	NN	_	16	compound	_	_
16	albicans	albican	NNS	NNS	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	lipopolysaccharide	lipopolysaccharide	NN	NN	_	13	conj	_	_
20	.	.	.	.	_	1	punct	_	_

1	Deactivation	deactivation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	phagocytes	phagocyte	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	critical	critical	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	limit	limit	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	11	det	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	8	dobj	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	detrimental	detrimental	JJ	JJ	_	6	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	face	face	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	progressive	progressive	JJ	JJ	_	21	amod	_	_
21	infection	infection	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	compared	compare	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	deactivating	deactivate	VBG	VBG	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	4	nmod	_	_
9	interleukin	interleukin	NN	NN	_	8	dep	_	_
10	10	10	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-10	il-10	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	on	on	IN	IN	_	23	case	_	_
15	human	human	JJ	JJ	_	23	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	mononuclear	mononuclear	JJ	JJ	_	19	amod	_	_
19	cell	cell	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PBMC	pbmc	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	responses	response	NNS	NNS	_	4	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	lipopolysaccharide	lipopolysaccharide	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	LPS	lps	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	25	punct	_	_
30	Cryptococcus	cryptococcus	NN	NN	_	31	compound	_	_
31	neoformans	neoforman	NNS	NNS	_	25	conj	_	_
32	,	,	,	,	_	25	punct	_	_
33	and	and	CC	CC	_	25	cc	_	_
34	Candida	candida	NN	NN	_	35	compound	_	_
35	albicans	albican	NNS	NNS	_	25	conj	_	_
36	.	.	.	.	_	2	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	effected	effect	VBD	VBD	_	0	root	_	_
3	dose-dependent	dose-dependent	JJ	JJ	_	4	amod	_	_
4	inhibition	inhibition	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	13	case	_	_
6	tumor	tumor	NN	NN	_	9	compound	_	_
7	necrosis	necrosis	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	release	release	NN	NN	_	4	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	PBMC	pbmc	NN	NN	_	13	nmod	_	_
16	stimulated	stimulate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	LPS	lps	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	C.	c.	FW	FW	_	21	compound	_	_
21	neoformans	neoformans	FW	FW	_	18	conj	_	_
22	,	,	,	,	_	2	punct	_	_
23	with	with	IN	IN	_	26	mark	_	_
24	significant	significant	JJ	JJ	_	25	amod	_	_
25	inhibition	inhibition	NN	NN	_	26	nsubj	_	_
26	seen	see	VBN	VBN	_	2	advcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	0.1	0.1	CD	CD	_	29	nummod	_	_
29	U/ml	u/ml	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	greater	greater	JJR	JJR	_	33	advmod	_	_
32	than	than	IN	IN	_	33	advmod	_	_
33	90	90	CD	CD	_	34	nummod	_	_
34	%	%	NN	NN	_	36	nsubj	_	_
35	inhibition	inhibition	NN	NN	_	34	dep	_	_
36	noted	note	VBN	VBN	_	26	conj	_	_
37	with	with	IN	IN	_	39	case	_	_
38	10	10	CD	CD	_	39	nummod	_	_
39	U/ml	u/ml	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	even	even	RB	RB	_	6	advmod	_	_
5	at	at	IN	IN	_	6	case	_	_
6	doses	dose	NNS	NNS	_	14	nmod	_	_
7	as	as	RB	RB	_	10	advmod	_	_
8	high	high	JJ	JJ	_	10	advmod	_	_
9	as	as	IN	IN	_	10	advmod	_	_
10	100	100	CD	CD	_	11	nummod	_	_
11	U/ml	u/ml	NN	NN	_	6	dep	_	_
12	,	,	,	,	_	14	punct	_	_
13	IL-10	il-10	NN	NN	_	14	nsubj	_	_
14	inhibited	inhibit	VBD	VBD	_	0	root	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	16	compound	_	_
16	release	release	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	response	response	NN	NN	_	21	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	C.	c.	FW	FW	_	21	compound	_	_
21	albicans	albicans	FW	FW	_	14	nmod	_	_
22	by	by	IN	IN	_	25	amod	_	_
23	only	only	RB	RB	_	24	advmod	_	_
24	50	50	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	14	dobj	_	_
26	.	.	.	.	_	14	punct	_	_

1	IL-10	il-10	NN	NN	_	3	nsubj	_	_
2	profoundly	profoundly	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	release	release	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-1beta	il-1beta	NN	NN	_	4	nmod	_	_
7	from	from	IN	IN	_	8	case	_	_
8	PBMC	pbmc	NN	NN	_	4	nmod	_	_
9	stimulated	stimulate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	13	case	_	_
11	all	all	DT	DT	_	12	advmod	_	_
12	three	three	CD	CD	_	13	nummod	_	_
13	stimuli	stimulus	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	release	release	NN	NN	_	2	conj	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	inhibited	inhibit	VBN	VBN	_	0	root	_	_
7	even	even	RB	RB	_	11	advmod	_	_
8	if	if	IN	IN	_	11	mark	_	_
9	IL-10	il-10	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	added	add	VBN	VBN	_	6	advcl	_	_
12	up	up	RP	RP	_	14	dep	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	8	8	CD	CD	_	15	nummod	_	_
15	h	h	NN	NN	_	11	nmod	_	_
16	after	after	IN	IN	_	15	case	_	_
17	cryptococcal	cryptococcal	JJ	JJ	_	18	amod	_	_
18	stimulation	stimulation	NN	NN	_	15	dep	_	_
19	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-1	il-1	NN	NN	_	8	compound	_	_
7	beta	beta	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	12	cop	_	_
10	of	of	IN	IN	_	12	case	_	_
11	lesser	lesser	JJR	JJR	_	12	amod	_	_
12	magnitude	magnitude	NN	NN	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	occurred	occur	VBD	VBD	_	12	conj	_	_
15	only	only	RB	RB	_	16	advmod	_	_
16	when	when	WRB	WRB	_	19	advmod	_	_
17	IL-10	il-10	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	added	add	VBN	VBN	_	14	advcl	_	_
20	within	within	IN	IN	_	22	case	_	_
21	2	2	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	cryptococcal	cryptococcal	JJ	JJ	_	25	amod	_	_
25	stimulation	stimulation	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	translocation	translocation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	response	response	NN	NN	_	9	dep	_	_
8	to	to	TO	TO	_	9	case	_	_
9	LPS	lps	NN	NN	_	2	nmod	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	fungal	fungal	JJ	JJ	_	14	amod	_	_
14	stimuli	stimulus	NNS	NNS	_	9	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	stimuli	stimulus	NNS	NNS	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	IL-10	il-10	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	PBMC	pbmc	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	although	although	IN	IN	_	16	mark	_	_
11	over	over	IN	IN	_	14	nummod	_	_
12	10-fold	10-fold	RB	RB	_	11	advmod	_	_
13	less	less	JJR	JJR	_	11	advmod	_	_
14	IL-10	il-10	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	released	release	VBN	VBN	_	4	advcl	_	_
17	in	in	IN	IN	_	21	case	_	_
18	response	response	NN	NN	_	21	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	C.	c.	FW	FW	_	21	compound	_	_
21	neoformans	neoformans	FW	FW	_	16	nmod	_	_
22	compared	compare	VBN	VBN	_	24	case	_	_
23	with	with	IN	IN	_	24	case	_	_
24	LPS	lps	NN	NN	_	16	advcl	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	C.	c.	NN	NN	_	27	compound	_	_
27	albicans	albican	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	while	while	IN	IN	_	5	mark	_	_
4	IL-10	il-10	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	24	advcl	_	_
6	deactivating	deactivate	VBG	VBG	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	PBMC	pbmc	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	5	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	all	all	DT	DT	_	13	advmod	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	stimuli	stimulus	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	24	punct	_	_
16	disparate	disparate	JJ	JJ	_	20	amod	_	_
17	stimulus-	stimulus-	NN	NN	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	response-specific	response-specific	JJ	JJ	_	17	conj	_	_
20	patterns	pattern	NNS	NNS	_	24	nsubjpass	_	_
21	of	of	IN	IN	_	22	case	_	_
22	deactivation	deactivation	NN	NN	_	20	nmod	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	seen	see	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Inhibition	inhibition	NN	NN	_	8	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	IL-10	il-10	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	proinflammatory	proinflammatory	JJ	JJ	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	release	release	NN	NN	_	1	nmod	_	_
8	appears	appear	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	occur	occur	VB	VB	_	8	xcomp	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	for	for	IN	IN	_	18	case	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	transcriptionally	transcriptionally	RB	RB	_	22	advmod	_	_
22	and	and	CC	CC	_	10	conj	_	_
23	posttranscriptionally	posttranscriptionally	RB	RB	_	22	advmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	IL-1beta	il-1beta	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Surfactant	surfactant	NN	NN	_	2	nsubj	_	_
2	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	biophysical	biophysical	JJ	JJ	_	5	amod	_	_
5	properties	property	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	pulmonary	pulmonary	JJ	JJ	_	8	amod	_	_
8	surfactant	surfactant	NN	NN	_	9	nsubj	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	immunomodulatory	immunomodulatory	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	synthetic	synthetic	JJ	JJ	_	17	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Exosurf	exosurf	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	modified	modify	VBN	VBN	_	13	amod	_	_
12	natural	natural	JJ	JJ	_	13	amod	_	_
13	surfactant	surfactant	NN	NN	_	6	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Survanta	survanta	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	downregulated	downregulate	VBD	VBD	_	3	ccomp	_	_
18	endotoxin-stimulated	endotoxin-stimulated	JJ	JJ	_	23	amod	_	_
19	inflammatory	inflammatory	JJ	JJ	_	22	amod	_	_
20	c	c	NN	NN	_	22	compound	_	_
21	ytokine	ytokine	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	23	compound	_	_
23	levels	level	NNS	NNS	_	17	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	products	product	NNS	NNS	_	23	conj	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	tumor	tumor	NN	NN	_	30	compound	_	_
29	necrosis	necrosis	NN	NN	_	30	compound	_	_
30	factor-alpha	factor-alpha	NN	NN	_	26	dep	_	_
31	-LSB-	-lsb-	-LRB-	-LRB-	_	32	punct	_	_
32	TNF	tnf	NN	NN	_	30	appos	_	_
33	-RSB-	-rsb-	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	30	punct	_	_
35	interleukin-1-beta	interleukin-1-beta	NN	NN	_	30	appos	_	_
36	-LSB-	-lsb-	-LRB-	-LRB-	_	37	punct	_	_
37	IL-1	il-1	NN	NN	_	35	appos	_	_
38	-RSB-	-rsb-	-RRB-	-RRB-	_	37	punct	_	_
39	,	,	,	,	_	30	punct	_	_
40	interleukin-6	interleukin-6	NN	NN	_	30	appos	_	_
41	-LSB-	-lsb-	-LRB-	-LRB-	_	42	punct	_	_
42	IL-6	il-6	NN	NN	_	40	appos	_	_
43	-RSB-	-rsb-	-RRB-	-RRB-	_	42	punct	_	_
44	)	)	-RRB-	-RRB-	_	30	punct	_	_
45	in	in	IN	IN	_	48	case	_	_
46	human	human	JJ	JJ	_	48	amod	_	_
47	alveolar	alveolar	NN	NN	_	48	compound	_	_
48	macrophages	macrophage	NNS	NNS	_	23	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	report	report	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	Exosurf	exosurf	NN	NN	_	12	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Survanta	survanta	NN	NN	_	9	conj	_	_
12	suppress	suppress	VBP	VBP	_	6	ccomp	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	secretion	secretion	NN	NN	_	14	conj	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	85	85	CD	CD	_	21	nummod	_	_
19	+/-	+/-	CC	CC	_	18	cc	_	_
20	4	4	CD	CD	_	18	conj	_	_
21	%	%	NN	NN	_	16	dep	_	_
22	mean	mean	NN	NN	_	24	compound	_	_
23	percent	percent	NN	NN	_	24	compound	_	_
24	inhibition	inhibition	NN	NN	_	21	dep	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	SEM	sem	NN	NN	_	24	conj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	Exosurf	exosurf	NN	NN	_	21	nmod	_	_
29	;	;	:	:	_	21	punct	_	_
30	71	71	CD	CD	_	33	nummod	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	6	6	CD	CD	_	30	conj	_	_
33	%	%	NN	NN	_	21	dep	_	_
34	by	by	IN	IN	_	35	case	_	_
35	Survanta	survanta	NN	NN	_	33	nmod	_	_
36	)	)	-RRB-	-RRB-	_	21	punct	_	_
37	by	by	IN	IN	_	39	case	_	_
38	endotoxin-stimulated	endotoxin-stimulated	JJ	JJ	_	39	amod	_	_
39	THP-1	thp-1	NN	NN	_	12	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	a	a	DT	DT	_	45	det	_	_
42	human	human	JJ	JJ	_	45	amod	_	_
43	monocytic	monocytic	JJ	JJ	_	45	amod	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	line	line	NN	NN	_	39	appos	_	_
46	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	3	mark	_	_
2	surfactant	surfactant	NN	NN	_	3	nsubj	_	_
3	downregulated	downregulate	VBD	VBD	_	21	advcl	_	_
4	inflammatory	inflammatory	JJ	JJ	_	5	amod	_	_
5	cytokine	cytokine	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	3	dobj	_	_
7	similarly	similarly	RB	RB	_	3	advmod	_	_
8	in	in	IN	IN	_	13	case	_	_
9	both	both	CC	CC	_	13	cc:preconj	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	alveolar	alveolar	JJ	JJ	_	13	amod	_	_
13	macrophages	macrophage	NNS	NNS	_	3	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	18	det	_	_
16	THP-1	thp-1	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	used	use	VBD	VBD	_	0	root	_	_
22	this	this	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	21	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	investigate	investigate	VB	VB	_	21	advcl	_	_
27	whether	whether	IN	IN	_	29	mark	_	_
28	surfactant	surfactant	JJ	JJ	_	29	nsubj	_	_
29	affected	affect	VBN	VBN	_	26	ccomp	_	_
30	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
31	mechanisms	mechanism	NNS	NNS	_	29	dobj	_	_
32	.	.	.	.	_	21	punct	_	_

1	Specifically	specifically	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	factor-kappa	factor-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	activation	activation	NN	NN	_	4	dobj	_	_
13	because	because	IN	IN	_	16	mark	_	_
14	it	it	PRP	PRP	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	crucial	crucial	JJ	JJ	_	4	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	many	many	JJ	JJ	_	24	amod	_	_
22	inflammatory	inflammatory	JJ	JJ	_	24	amod	_	_
23	cytokine	cytokine	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	19	nmod	_	_
25	including	include	VBG	VBG	_	26	case	_	_
26	TNF	tnf	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	IL-1	il-1	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	IL-6	il-6	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	4	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	both	both	DT	DT	_	8	det	_	_
8	surfactants	surfactant	NNS	NNS	_	9	nsubj	_	_
9	decreased	decrease	VBD	VBD	_	5	ccomp	_	_
10	activation	activation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	p65	p65	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p50	p50	NN	NN	_	5	conj	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	components	component	NNS	NNS	_	5	dep	_	_
11	in	in	IN	IN	_	14	case	_	_
12	LPS-activated	lps-activated	JJ	JJ	_	14	amod	_	_
13	THP-1	thp-1	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	2	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	confirmed	confirm	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	antibody	antibody	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	supershifts	supershift	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	mobility	mobility	NN	NN	_	25	compound	_	_
25	assays	assay	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	suggest	suggest	VB	VB	_	5	acl	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	surfactant	surfactant	NN	NN	_	12	nmod:poss	_	_
10	's	's	POS	POS	_	12	case	_	_
11	suppressive	suppressive	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	18	nsubj	_	_
13	on	on	IN	IN	_	16	case	_	_
14	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	12	nmod	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	involve	involve	VB	VB	_	7	ccomp	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	18	dobj	_	_
21	through	through	IN	IN	_	22	case	_	_
22	inhibition	inhibition	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	regulator	regulator	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	c-myb	c-myb	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	during	during	IN	IN	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Resting	rest	VBG	VBG	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	very	very	RB	RB	_	6	advmod	_	_
6	low	low	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	c-Myb	c-myb	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	c-myb	c-myb	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	much	much	JJ	JJ	_	16	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	increase	increase	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	expression	expression	NN	NN	_	13	nmod	_	_
16	occurs	occur	VBZ	VBZ	_	8	conj	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	region	region	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	c-myb	c-myb	NN	NN	_	10	compound	_	_
8	5'	5'	JJ	JJ	_	10	amod	_	_
9	flanking	flanking	JJ	JJ	_	10	amod	_	_
10	sequence	sequence	NN	NN	_	4	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	increased	increase	VBD	VBD	_	4	acl:relcl	_	_
13	c-myb	c-myb	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	during	during	IN	IN	_	17	case	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	footprinting	footprinting	NN	NN	_	8	nsubjpass	_	_
4	by	by	IN	IN	_	6	case	_	_
5	ligation-mediated	ligation-mediated	JJ	JJ	_	6	amod	_	_
6	PCR	pcr	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	performed	perform	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	correlate	correlate	VB	VB	_	8	xcomp	_	_
11	in	in	FW	FW	_	14	amod	_	_
12	vivo	vivo	FW	FW	_	11	dep	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	10	dobj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	footprint	footprint	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	visible	visible	JJ	JJ	_	0	root	_	_
6	over	over	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	region	region	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	c-myb	c-myb	NN	NN	_	14	compound	_	_
12	5'	5'	JJ	JJ	_	14	amod	_	_
13	flanking	flanking	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	8	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	5	nmod	_	_
19	but	but	CC	CC	_	18	cc	_	_
20	not	not	RB	RB	_	24	neg	_	_
21	in	in	IN	IN	_	24	case	_	_
22	unactivated	unactivated	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	18	conj	_	_
25	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	23	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EMSA	emsa	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	with	with	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	extract	extract	NN	NN	_	5	nmod	_	_
12	from	from	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	an	a	DT	DT	_	18	det	_	_
18	oligonucleotide	oligonucleotide	NN	NN	_	11	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	this	this	DT	DT	_	22	det	_	_
21	binding	bind	VBG	VBG	_	22	amod	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
24	a	a	DT	DT	_	27	det	_	_
25	new	new	JJ	JJ	_	27	amod	_	_
26	protein-DNA	protein-dna	JJ	JJ	_	27	amod	_	_
27	complex	complex	NN	NN	_	23	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	referred	refer	VBN	VBN	_	27	acl	_	_
30	to	to	TO	TO	_	29	nmod	_	_
31	as	as	IN	IN	_	32	case	_	_
32	CMAT	cmat	NN	NN	_	29	nmod	_	_
33	for	for	IN	IN	_	38	case	_	_
34	c-myb	c-myb	NN	NN	_	38	compound	_	_
35	in	in	IN	IN	_	38	amod	_	_
36	activated	activate	VBN	VBN	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	29	nmod	_	_
39	;	;	:	:	_	23	punct	_	_
40	this	this	DT	DT	_	41	det	_	_
41	complex	complex	NN	NN	_	44	nsubj	_	_
42	was	be	VBD	VBD	_	44	cop	_	_
43	not	not	RB	RB	_	44	neg	_	_
44	present	present	JJ	JJ	_	23	parataxis	_	_
45	in	in	IN	IN	_	48	case	_	_
46	unactivated	unactivated	JJ	JJ	_	48	amod	_	_
47	T	t	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	44	nmod	_	_
49	.	.	.	.	_	23	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	binding	bind	VBG	VBG	_	4	amod	_	_
4	site	site	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	24	advcl	_	_
6	some	some	DT	DT	_	8	det	_	_
7	sequence	sequence	NN	NN	_	8	compound	_	_
8	similarity	similarity	NN	NN	_	5	dobj	_	_
9	with	with	IN	IN	_	21	case	_	_
10	the	the	DT	DT	_	21	det	_	_
11	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
12	factor	factor	NN	NN	_	21	compound	_	_
13	of	of	IN	IN	_	21	amod	_	_
14	activated	activate	VBN	VBN	_	21	amod	_	_
15	T	t	NN	NN	_	21	compound	_	_
16	cells	cell	NNS	NNS	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	NFAT	nfat	NN	NN	_	21	compound	_	_
19	)	)	-RRB-	-RRB-	_	21	punct	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	8	nmod	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	compared	compare	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	kinetics	kinetics	NNS	NNS	_	24	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	induction	induction	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	two	two	CD	CD	_	33	nummod	_	_
32	binding	bind	VBG	VBG	_	33	amod	_	_
33	complexes	complex	NNS	NNS	_	28	nmod	_	_
34	and	and	CC	CC	_	26	cc	_	_
35	the	the	DT	DT	_	37	det	_	_
36	molecular	molecular	JJ	JJ	_	37	amod	_	_
37	masses	mass	NNS	NNS	_	26	conj	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	two	two	CD	CD	_	41	nummod	_	_
41	proteins	protein	NNS	NNS	_	37	nmod	_	_
42	.	.	.	.	_	24	punct	_	_

1	Studies	study	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	kinetics	kinetics	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	induction	induction	NN	NN	_	4	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	the	the	DT	DT	_	13	det	_	_
10	NFAT	nfat	NN	NN	_	13	compound	_	_
11	EMSA	emsa	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	14	nsubj	_	_
14	appeared	appear	VBD	VBD	_	7	ccomp	_	_
15	earlier	earlier	RBR	RBR	_	14	advmod	_	_
16	than	than	IN	IN	_	19	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CMAT	cmat	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	15	advcl	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NFAT	nfat	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	migrated	migrate	VBD	VBD	_	0	root	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	slowly	slowly	RB	RB	_	4	advmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	sodium	sodium	NN	NN	_	12	compound	_	_
10	dodecyl	dodecyl	NN	NN	_	12	compound	_	_
11	sulfate-polyacrylamide	sulfate-polyacrylamide	JJ	JJ	_	12	amod	_	_
12	gel	gel	NN	NN	_	6	nmod	_	_
13	than	than	IN	IN	_	17	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CMAT	cmat	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	17	nsubj	_	_
17	did	do	VBD	VBD	_	6	advcl	_	_
18	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	an	a	DT	DT	_	5	det	_	_
5	antibody	antibody	NN	NN	_	10	nsubj	_	_
6	against	against	IN	IN	_	7	case	_	_
7	NFAT	nfat	NN	NN	_	5	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	cross-react	cross-react	VB	VB	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CMAT	cmat	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	appearance	appearance	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	CMAT	cmat	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	cyclosporin	cyclosporin	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	rapamycin	rapamycin	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CMAT	cmat	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	10	mark	_	_
6	be	be	VB	VB	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	novel	novel	JJ	JJ	_	10	amod	_	_
9	inducible	inducible	JJ	JJ	_	8	dep	_	_
10	protein	protein	NN	NN	_	4	xcomp	_	_
11	involved	involve	VBN	VBN	_	10	acl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	c-myb	c-myb	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	during	during	IN	IN	_	20	case	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	AM580	am580	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	stable	stable	JJ	JJ	_	6	amod	_	_
5	benzoic	benzoic	JJ	JJ	_	4	dep	_	_
6	derivative	derivative	NN	NN	_	1	appos	_	_
7	of	of	IN	IN	_	9	case	_	_
8	retinoic	retinoic	JJ	JJ	_	9	amod	_	_
9	acid	acid	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	has	have	VBZ	VBZ	_	0	root	_	_
12	powerful	powerful	JJ	JJ	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	selective	selective	JJ	JJ	_	12	conj	_	_
15	cyto-differentiating	cyto-differentiating	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	11	dobj	_	_
17	on	on	IN	IN	_	21	case	_	_
18	acute	acute	JJ	JJ	_	21	amod	_	_
19	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
20	leukemia	leukemia	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	All-trans	all-trans	JJ	JJ	_	3	amod	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ATRA	atra	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	successfully	successfully	RB	RB	_	9	advmod	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cyto-differentiating	cyto-differentiating	JJ	JJ	_	13	amod	_	_
13	treatment	treatment	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	promyelocytic	promyelocytic	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	APL	apl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	9	punct	_	_

1	Paradoxically	paradoxically	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	APL	apl	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	PML-RAR	pml-rar	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	an	a	DT	DT	_	10	det	_	_
9	aberrant	aberrant	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	6	appos	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	retinoic	retinoic	JJ	JJ	_	17	amod	_	_
14	acid	acid	NN	NN	_	17	compound	_	_
15	receptor	receptor	NN	NN	_	17	compound	_	_
16	type	type	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	RAR	rar	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	derived	derive	VBN	VBN	_	10	acl	_	_
23	from	from	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	leukemia-specific	leukemia-specific	JJ	JJ	_	28	amod	_	_
26	t(15;17)	t(15;17)	NN	NN	_	28	compound	_	_
27	chromosomal	chromosomal	NN	NN	_	28	compound	_	_
28	translocation	translocation	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	AM580	am580	NN	NN	_	22	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	10	det	_	_
8	stable	stable	JJ	JJ	_	10	amod	_	_
9	retinobenzoic	retinobenzoic	JJ	JJ	_	8	dep	_	_
10	derivative	derivative	NN	NN	_	5	appos	_	_
11	originally	originally	RB	RB	_	12	advmod	_	_
12	synthesized	synthesize	VBN	VBN	_	10	acl	_	_
13	as	as	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	RAR	rar	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	agonist	agonist	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	is	be	VBZ	VBZ	_	22	cop	_	_
20	a	a	DT	DT	_	22	det	_	_
21	powerful	powerful	JJ	JJ	_	22	amod	_	_
22	inducer	inducer	NN	NN	_	2	ccomp	_	_
23	of	of	IN	IN	_	25	case	_	_
24	granulocytic	granulocytic	JJ	JJ	_	25	amod	_	_
25	maturation	maturation	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	NB4	nb4	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	an	a	DT	DT	_	32	det	_	_
30	APL-derived	apl-derived	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	line	line	NN	NN	_	27	appos	_	_
33	,	,	,	,	_	27	punct	_	_
34	and	and	CC	CC	_	27	cc	_	_
35	in	in	IN	IN	_	39	case	_	_
36	freshly	freshly	RB	RB	_	39	advmod	_	_
37	isolated	isolate	VBN	VBN	_	39	amod	_	_
38	APL	apl	NN	NN	_	39	compound	_	_
39	blasts	blast	NNS	NNS	_	27	conj	_	_
40	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	treatment	treatment	NN	NN	_	23	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	APL	apl	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	AM580	am580	NN	NN	_	2	nmod	_	_
8	either	either	CC	CC	_	2	dep	_	_
9	alone	alone	RB	RB	_	8	dep	_	_
10	or	or	CC	CC	_	8	cc	_	_
11	in	in	IN	IN	_	12	case	_	_
12	combination	combination	NN	NN	_	8	conj	_	_
13	with	with	IN	IN	_	16	case	_	_
14	granulocyte	granulocyte	NN	NN	_	16	compound	_	_
15	colony-stimulating	colony-stimulating	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	G-CSF	g-csf	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	23	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	compound	compound	NN	NN	_	23	nsubj	_	_
23	induces	induce	VBZ	VBZ	_	0	root	_	_
24	granulocytic	granulocytic	JJ	JJ	_	25	amod	_	_
25	maturation	maturation	NN	NN	_	23	dobj	_	_
26	,	,	,	,	_	23	punct	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	assessed	assess	VBN	VBN	_	23	advcl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	determination	determination	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	levels	level	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	leukocyte	leukocyte	NN	NN	_	37	compound	_	_
36	alkaline	alkaline	NN	NN	_	37	compound	_	_
37	phosphatase	phosphatase	NN	NN	_	33	nmod	_	_
38	,	,	,	,	_	37	punct	_	_
39	CD11b	cd11b	NN	NN	_	37	conj	_	_
40	,	,	,	,	_	37	punct	_	_
41	CD33	cd33	NN	NN	_	37	conj	_	_
42	,	,	,	,	_	37	punct	_	_
43	and	and	CC	CC	_	37	cc	_	_
44	G-CSF	g-csf	NN	NN	_	45	compound	_	_
45	receptor	receptor	NN	NN	_	37	conj	_	_
46	mRNA	mrna	NN	NN	_	37	dep	_	_
47	,	,	,	,	_	23	punct	_	_
48	at	at	IN	IN	_	49	case	_	_
49	concentrations	concentration	NNS	NNS	_	23	nmod	_	_
50	that	that	WDT	WDT	_	55	nsubj	_	_
51	are	be	VBP	VBP	_	55	cop	_	_
52	10-	10-	CD	CD	_	55	nmod:npmod	_	_
53	to	to	TO	TO	_	52	dep	_	_
54	100-fold	100-fold	RB	RB	_	52	advmod	_	_
55	lower	lower	JJR	JJR	_	49	acl:relcl	_	_
56	than	than	IN	IN	_	57	case	_	_
57	those	those	DT	DT	_	55	nmod	_	_
58	of	of	IN	IN	_	59	case	_	_
59	ATRA	atra	NN	NN	_	57	nmod	_	_
60	necessary	necessary	JJ	JJ	_	59	amod	_	_
61	to	to	TO	TO	_	62	mark	_	_
62	produce	produce	VB	VB	_	59	acl	_	_
63	similar	similar	JJ	JJ	_	64	amod	_	_
64	effects	effect	NNS	NNS	_	62	dobj	_	_
65	.	.	.	.	_	23	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	AM580	am580	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	effective	effective	JJ	JJ	_	0	root	_	_
8	as	as	IN	IN	_	9	case	_	_
9	ATRA	atra	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	modulating	modulate	VBG	VBG	_	7	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	these	these	DT	DT	_	17	det	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	markers	marker	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	HL-60	hl-60	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	13	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	in	in	IN	IN	_	27	case	_	_
25	freshly	freshly	RB	RB	_	27	advmod	_	_
26	isolated	isolate	VBN	VBN	_	27	amod	_	_
27	granulocytes	granulocyte	NNS	NNS	_	22	conj	_	_
28	obtained	obtain	VBN	VBN	_	27	acl	_	_
29	from	from	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
32	blood	blood	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	37	case	_	_
34	chronic	chronic	JJ	JJ	_	37	amod	_	_
35	myelogenous	myelogenous	JJ	JJ	_	37	amod	_	_
36	leukemia	leukemia	NN	NN	_	37	compound	_	_
37	patients	patient	NNS	NNS	_	32	nmod	_	_
38	during	during	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	stable	stable	JJ	JJ	_	41	amod	_	_
41	phase	phase	NN	NN	_	37	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	disease	disease	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	NB4	nb4	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	two	two	CD	CD	_	10	nummod	_	_
6	other	other	JJ	JJ	_	10	amod	_	_
7	synthetic	synthetic	JJ	JJ	_	10	amod	_	_
8	nonselective	nonselective	JJ	JJ	_	7	dep	_	_
9	RAR	rar	NN	NN	_	10	compound	_	_
10	ligands	ligand	NNS	NNS	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	capable	capable	JJ	JJ	_	0	root	_	_
13	of	of	IN	IN	_	14	mark	_	_
14	inducing	induce	VBG	VBG	_	12	advcl	_	_
15	LAP	lap	NN	NN	_	14	iobj	_	_
16	as	as	RB	RB	_	17	advmod	_	_
17	much	much	JJ	JJ	_	14	dobj	_	_
18	as	as	IN	IN	_	19	case	_	_
19	AM580	am580	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	whereas	whereas	IN	IN	_	30	mark	_	_
22	RAR	rar	NN	NN	_	23	compound	_	_
23	beta-	beta-	NN	NN	_	30	nsubj	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	RAR	rar	NN	NN	_	23	conj	_	_
26	gamma-specific	gamma-specific	JJ	JJ	_	25	amod	_	_
27	ligands	ligand	NNS	NNS	_	23	dep	_	_
28	are	be	VBP	VBP	_	30	cop	_	_
29	totally	totally	RB	RB	_	30	advmod	_	_
30	ineffective	ineffective	JJ	JJ	_	12	advcl	_	_
31	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	AM580	am580	NN	NN	_	8	nsubj	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	powerful	powerful	JJ	JJ	_	3	ccomp	_	_
9	than	than	IN	IN	_	10	case	_	_
10	ATRA	atra	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	modulating	modulate	VBG	VBG	_	8	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	antigens	antigen	NNS	NNS	_	14	nmod	_	_
18	only	only	RB	RB	_	20	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	25	nmod	_	_
23	PML-RAR	pml-rar	NN	NN	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	present	present	JJ	JJ	_	20	acl:relcl	_	_
26	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	using	use	VBG	VBG	_	17	dep	_	_
5	COS-7	cos-7	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	4	dobj	_	_
7	transiently	transiently	RB	RB	_	8	advmod	_	_
8	transfected	transfect	VBN	VBN	_	6	acl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	PML-RAR	pml-rar	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	15	det	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	RAR	rar	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	10	conj	_	_
16	,	,	,	,	_	17	punct	_	_
17	show	show	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	AM580	am580	NN	NN	_	20	nsubj	_	_
20	has	have	VBZ	VBZ	_	17	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	lower	lower	JJR	JJR	_	23	amod	_	_
23	affinity	affinity	NN	NN	_	20	dobj	_	_
24	than	than	IN	IN	_	25	case	_	_
25	ATRA	atra	NN	NN	_	23	nmod	_	_
26	for	for	IN	IN	_	28	case	_	_
27	both	both	DT	DT	_	28	det	_	_
28	receptors	receptor	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	17	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	16	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PML-RAR	pml-rar	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	synthetic	synthetic	JJ	JJ	_	11	amod	_	_
11	retinoid	retinoid	NN	NN	_	16	nsubj	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	much	much	RB	RB	_	15	advmod	_	_
15	better	better	JJR	JJR	_	16	amod	_	_
16	transactivator	transactivator	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	21	case	_	_
18	retinoic	retinoic	JJ	JJ	_	21	amod	_	_
19	acid-responsive	acid-responsive	JJ	JJ	_	21	amod	_	_
20	element-containing	element-containing	JJ	JJ	_	21	amod	_	_
21	promoters	promoter	NNS	NNS	_	16	nmod	_	_
22	than	than	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	natural	natural	JJ	JJ	_	25	amod	_	_
25	retinoid	retinoid	NN	NN	_	16	nmod	_	_
26	,	,	,	,	_	16	punct	_	_
27	whereas	whereas	IN	IN	_	39	mark	_	_
28	,	,	,	,	_	39	punct	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	presence	presence	NN	NN	_	39	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	RAR	rar	NN	NN	_	34	compound	_	_
34	alpha	alpha	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	39	punct	_	_
36	AM580	am580	NN	NN	_	39	nsubj	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	ATRA	atra	NN	NN	_	36	conj	_	_
39	have	have	VBP	VBP	_	16	advcl	_	_
40	similar	similar	JJ	JJ	_	41	amod	_	_
41	activity	activity	NN	NN	_	39	dobj	_	_
42	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	explain	explain	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	strong	strong	JJ	JJ	_	7	amod	_	_
6	cyto-differentiating	cyto-differentiating	JJ	JJ	_	5	dep	_	_
7	potential	potential	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	AM580	am580	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	PML-RAR-containing	pml-rar-containing	JJ	JJ	_	13	amod	_	_
12	leukemic	leukemic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	a	a	DT	DT	_	8	det	_	_
4	herpesvirus	herpesvirus	NN	NN	_	8	compound	_	_
5	Saimiri	saimiri	NN	NN	_	8	compound	_	_
6	cis-acting	cis-acting	JJ	JJ	_	8	amod	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	fragment	fragment	NN	NN	_	1	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	permits	permit	VBZ	VBZ	_	8	acl:relcl	_	_
11	stable	stable	JJ	JJ	_	12	amod	_	_
12	replication	replication	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	episomes	episome	NNS	NNS	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	transformed	transform	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Herpesvirus	herpesvirus	NN	NN	_	2	compound	_	_
2	saimiri	saimiri	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	lymphotropic	lymphotropic	JJ	JJ	_	6	amod	_	_
6	herpesvirus	herpesvirus	NN	NN	_	0	root	_	_
7	capable	capable	JJ	JJ	_	6	amod	_	_
8	of	of	IN	IN	_	9	mark	_	_
9	immortalizing	immortalize	VBG	VBG	_	7	advcl	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	transforming	transform	VBG	VBG	_	9	conj	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	dobj	_	_
14	both	both	CC	CC	_	17	cc:preconj	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	17	advmod	_	_
17	and	and	CC	CC	_	9	advmod	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vivo	vivo	FW	FW	_	17	advmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Immortalized	immortalize	VBN	VBN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	transformed	transform	VBN	VBN	_	1	conj	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	dep	_	_
6	harbor	harbor	VBP	VBP	_	0	root	_	_
7	several	several	JJ	JJ	_	8	amod	_	_
8	copies	copy	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	genome	genome	NN	NN	_	8	nmod	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	persisting	persist	VBG	VBG	_	16	amod	_	_
16	genome	genome	NN	NN	_	6	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mapping	mapping	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	cis-acting	cis-acting	JJ	JJ	_	8	amod	_	_
6	genetic	genetic	JJ	JJ	_	8	amod	_	_
7	cis-acting	cis-acting	JJ	JJ	_	8	amod	_	_
8	segment	segment	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	oriP	orip	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	required	require	VBN	VBN	_	8	acl	_	_
13	for	for	IN	IN	_	16	case	_	_
14	viral	viral	JJ	JJ	_	16	amod	_	_
15	episomal	episomal	JJ	JJ	_	14	dep	_	_
16	maintenance	maintenance	NN	NN	_	12	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	reported	report	VBN	VBN	_	0	root	_	_
19	here	here	RB	RB	_	18	advmod	_	_
20	.	.	.	.	_	18	punct	_	_

1	Viral	viral	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	fragments	fragment	NNS	NNS	_	9	nsubjpass	_	_
4	that	that	WDT	WDT	_	6	nsubj	_	_
5	potentially	potentially	RB	RB	_	6	advmod	_	_
6	contain	contain	VBP	VBP	_	3	acl:relcl	_	_
7	oriP	orip	NN	NN	_	6	dobj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	cloned	clone	VBN	VBN	_	0	root	_	_
10	into	into	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	plasmid	plasmid	NN	NN	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	contains	contain	VBZ	VBZ	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	hygromycin	hygromycin	NN	NN	_	18	compound	_	_
17	resistance	resistance	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	9	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	several	several	JJ	JJ	_	3	amod	_	_
3	round	round	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	subcloning	subcloning	NN	NN	_	3	nmod	_	_
6	followed	follow	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	transfection	transfection	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	oriP	orip	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	mapped	map	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	1.955-kb	1.955-kb	JJ	JJ	_	17	amod	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	segment	segment	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	viral	viral	JJ	JJ	_	3	amod	_	_
3	fragment	fragment	NN	NN	_	4	nsubj	_	_
4	permits	permit	VBZ	VBZ	_	0	root	_	_
5	stable	stable	JJ	JJ	_	7	amod	_	_
6	plasmid	plasmid	NN	NN	_	7	compound	_	_
7	replication	replication	NN	NN	_	4	dobj	_	_
8	without	without	IN	IN	_	9	case	_	_
9	deletion	deletion	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	rearrangement	rearrangement	NN	NN	_	9	conj	_	_
12	as	as	RB	RB	_	7	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	episomal	episomal	JJ	JJ	_	16	amod	_	_
16	maintenance	maintenance	NN	NN	_	7	conj	_	_
17	without	without	IN	IN	_	18	case	_	_
18	integration	integration	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	recombination	recombination	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	oriP	orip	NN	NN	_	2	nmod	_	_
5	depends	depend	VBZ	VBZ	_	0	root	_	_
6	on	on	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	trans-acting	trans-acting	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	s	s	NNS	NNS	_	5	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	encoded	encode	VBN	VBN	_	11	acl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	genome	genome	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	1.955-kb	1.955-kb	JJ	JJ	_	4	amod	_	_
3	viral	viral	JJ	JJ	_	4	amod	_	_
4	segment	segment	NN	NN	_	5	nsubj	_	_
5	includes	include	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	dyad	dyad	JJ	JJ	_	9	amod	_	_
8	symmetry	symmetry	NN	NN	_	9	compound	_	_
9	region	region	NN	NN	_	5	dobj	_	_
10	located	located	JJ	JJ	_	9	amod	_	_
11	between	between	IN	IN	_	16	case	_	_
12	two	two	CD	CD	_	16	nummod	_	_
13	small	small	JJ	JJ	_	16	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	RNA	rna	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	10	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	located	located	JJ	JJ	_	5	conj	_	_
20	upstream	upstream	RB	RB	_	19	advmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	dihydrofolate	dihydrofolate	JJ	JJ	_	26	amod	_	_
24	reductase	reductase	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	homolog	homolog	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	oriP	orip	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	5	dobj	_	_
8	distinct	distinct	JJ	JJ	_	7	amod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	those	those	DT	DT	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	viruses	virus	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
5	factor	factor	NN	NN	_	9	compound	_	_
6	of	of	IN	IN	_	9	amod	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	stably	stably	RB	RB	_	12	advmod	_	_
12	transfected	transfect	VBN	VBN	_	15	amod	_	_
13	Jurkat	jurkat	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	clones	clone	NNS	NNS	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	Jurkat	jurkat	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	clones	clone	NNS	NNS	_	8	nsubjpass	_	_
5	have	have	VBP	VBP	_	8	aux	_	_
6	been	be	VBN	VBN	_	8	auxpass	_	_
7	stably	stably	RB	RB	_	8	advmod	_	_
8	transfected	transfect	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	vector	vector	NN	NN	_	8	nmod	_	_
13	for	for	IN	IN	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
16	factor	factor	NN	NN	_	20	compound	_	_
17	of	of	IN	IN	_	20	amod	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	12	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NFAT	nfat	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	8	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	they	they	PRP	PRP	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	secreted	secrete	VBN	VBN	_	14	amod	_	_
10	heat	heat	NN	NN	_	11	nmod:npmod	_	_
11	stable	stable	JJ	JJ	_	9	dep	_	_
12	placental	placental	JJ	JJ	_	14	amod	_	_
13	alkaline	alkaline	NN	NN	_	14	compound	_	_
14	phosphatase	phosphatase	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	clones	clone	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	NFAT	nfat	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	18	nsubjpass	_	_
10	induced	induce	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	14	case	_	_
12	phorbol	phorbol	NN	NN	_	14	compound	_	_
13	12-myristate	12-myristate	NN	NN	_	14	compound	_	_
14	13-acetate	13-acetate	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	ionomycin	ionomycin	NN	NN	_	14	conj	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	inhibited	inhibit	VBN	VBN	_	6	ccomp	_	_
19	by	by	IN	IN	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	cyclosporin	cyclosporin	NN	NN	_	22	compound	_	_
22	A	a	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CsA	csa	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IC50	ic50	NN	NN	_	22	dep	_	_
28	=	=	JJ	JJ	_	27	amod	_	_
29	8	8	CD	CD	_	30	nummod	_	_
30	nM	nm	NN	NN	_	28	dep	_	_
31	)	)	-RRB-	-RRB-	_	27	punct	_	_
32	and	and	CC	CC	_	22	cc	_	_
33	FK506	fk506	NN	NN	_	22	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	IC50	ic50	NN	NN	_	33	dep	_	_
36	=	=	JJ	JJ	_	35	amod	_	_
37	160	160	CD	CD	_	38	nummod	_	_
38	pM	pm	NN	NN	_	36	dep	_	_
39	)	)	-RRB-	-RRB-	_	35	punct	_	_
40	,	,	,	,	_	18	punct	_	_
41	presumably	presumably	RB	RB	_	43	advmod	_	_
42	by	by	IN	IN	_	43	case	_	_
43	inhibition	inhibition	NN	NN	_	18	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	calcineurin	calcineurin	NN	NN	_	46	compound	_	_
46	activity	activity	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	6	punct	_	_

1	Selective	selective	JJ	JJ	_	3	amod	_	_
2	phosphatase	phosphatase	NN	NN	_	3	compound	_	_
3	inhibitors	inhibitor	NNS	NNS	_	31	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	phosphatase	phosphatase	NN	NN	_	3	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PP1	pp1	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	2A	2a	NN	NN	_	6	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PP2A	pp2a	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	that	that	WDT	WDT	_	19	nsubj	_	_
17	do	do	VBP	VBP	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	inhibit	inhibit	VB	VB	_	3	acl:relcl	_	_
20	calcineurin	calcineurin	NN	NN	_	19	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	such	such	JJ	JJ	_	25	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	okadaic	okadaic	JJ	JJ	_	25	amod	_	_
25	acid	acid	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	calyculin	calyculin	NN	NN	_	28	compound	_	_
28	A	a	NN	NN	_	25	conj	_	_
29	,	,	,	,	_	3	punct	_	_
30	also	also	RB	RB	_	31	advmod	_	_
31	inhibited	inhibit	VBD	VBD	_	0	root	_	_
32	NFAT	nfat	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	31	dobj	_	_
34	with	with	IN	IN	_	35	case	_	_
35	IC50s	ic50s	NN	NN	_	33	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	87	87	CD	CD	_	38	nummod	_	_
38	nM	nm	NN	NN	_	33	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	4	4	CD	CD	_	41	nummod	_	_
41	nM	nm	NN	NN	_	38	conj	_	_
42	,	,	,	,	_	31	punct	_	_
43	respectively	respectively	RB	RB	_	31	advmod	_	_
44	,	,	,	,	_	31	punct	_	_
45	suggesting	suggest	VBG	VBG	_	31	advcl	_	_
46	that	that	IN	IN	_	53	mark	_	_
47	okadaic	okadaic	JJ	JJ	_	48	amod	_	_
48	acid	acid	NN	NN	_	53	nsubj	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	related	related	JJ	JJ	_	51	amod	_	_
51	inhibitors	inhibitor	NNS	NNS	_	48	conj	_	_
52	may	may	MD	MD	_	53	aux	_	_
53	block	block	VB	VB	_	45	ccomp	_	_
54	NFAT	nfat	NN	NN	_	55	compound	_	_
55	activation	activation	NN	NN	_	53	dobj	_	_
56	through	through	IN	IN	_	58	case	_	_
57	the	the	DT	DT	_	58	det	_	_
58	inhibition	inhibition	NN	NN	_	53	nmod	_	_
59	of	of	IN	IN	_	60	case	_	_
60	PP1	pp1	NN	NN	_	58	nmod	_	_
61	,	,	,	,	_	60	punct	_	_
62	instead	instead	RB	RB	_	60	cc	_	_
63	of	of	IN	IN	_	62	mwe	_	_
64	PP2A	pp2a	NN	NN	_	60	conj	_	_
65	.	.	.	.	_	31	punct	_	_

1	NFAT	nfat	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	agents	agent	NNS	NNS	_	5	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	increase	increase	VBP	VBP	_	7	acl:relcl	_	_
10	cAMP	camp	NN	NN	_	11	compound	_	_
11	concentrations	concentration	NNS	NNS	_	9	dobj	_	_
12	such	such	JJ	JJ	_	15	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	dibutyryl	dibutyryl	JJ	JJ	_	15	amod	_	_
15	cAMP	camp	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	forskolin	forskolin	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	prostaglandin	prostaglandin	NN	NN	_	20	compound	_	_
20	E2	e2	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	5	det	_	_
2	stable	stable	JJ	JJ	_	5	amod	_	_
3	Jurkat	jurkat	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	6	nsubj	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	11	det	_	_
8	convenient	convenient	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	sensitive	sensitive	JJ	JJ	_	8	conj	_	_
11	tool	tool	NN	NN	_	6	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	study	study	VB	VB	_	11	acl	_	_
14	NFAT	nfat	NN	NN	_	15	compound	_	_
15	regulation	regulation	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	6	punct	_	_

1	Menopause	menopause	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	associated	associate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	increase	increase	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	number	number	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	a	a	DT	DT	_	15	det	_	_
14	relative	relative	JJ	JJ	_	15	amod	_	_
15	decrease	decrease	NN	NN	_	7	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	estrogen	estrogen	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
25	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	PROBLEM	problem	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	5	det	_	_
4	clinical	clinical	JJ	JJ	_	5	amod	_	_
5	significance	significance	NN	NN	_	20	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	differential	differential	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	estrogen	estrogen	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	ER	er	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	in	in	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	evaluated	evaluate	VBN	VBN	_	1	dep	_	_
21	.	.	.	.	_	20	punct	_	_

1	METHOD	method	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Two	two	CD	CD	_	7	nummod	_	_
4	color	color	NN	NN	_	7	compound	_	_
5	flow	flow	NN	NN	_	7	compound	_	_
6	cytometry	cytometry	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	1	dep	_	_
10	on	on	IN	IN	_	13	case	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	samples	sample	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	young	young	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	postmenopausal	postmenopausal	JJ	JJ	_	15	conj	_	_
18	females	female	NNS	NNS	_	15	dep	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	postmenopausal	postmenopausal	JJ	JJ	_	21	amod	_	_
21	females	female	NNS	NNS	_	15	conj	_	_
22	treated	treat	VBN	VBN	_	21	acl	_	_
23	with	with	IN	IN	_	26	case	_	_
24	estrogen	estrogen	NN	NN	_	26	compound	_	_
25	replacement	replacement	NN	NN	_	26	compound	_	_
26	therapy	therapy	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	monocyte	monocyte	NN	NN	_	18	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	lymphocyte	lymphocyte	NN	NN	_	5	conj	_	_
8	counts	count	NNS	NNS	_	5	dep	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	the	the	DT	DT	_	13	det	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	estrogen	estrogen	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	5	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	each	each	DT	DT	_	16	det	_	_
16	patient	patient	NN	NN	_	5	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	determine	determine	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	During	during	IN	IN	_	4	case	_	_
4	menopause	menopause	NN	NN	_	6	nmod	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	is	be	VBZ	VBZ	_	1	dep	_	_
7	a	a	DT	DT	_	9	det	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	decrease	decrease	NN	NN	_	6	nsubj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	percentage	percentage	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	ER	er	NN	NN	_	16	compound	_	_
15	positive	positive	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	an	a	DT	DT	_	20	det	_	_
20	increase	increase	NN	NN	_	9	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	blood	blood	NN	NN	_	23	compound	_	_
23	monocyte	monocyte	NN	NN	_	24	compound	_	_
24	number	number	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	declines	decline	VBZ	VBZ	_	24	acl:relcl	_	_
28	following	follow	VBG	VBG	_	31	case	_	_
29	estrogen	estrogen	NN	NN	_	31	compound	_	_
30	replacement	replacement	NN	NN	_	31	compound	_	_
31	therapy	therapy	NN	NN	_	27	nmod	_	_
32	to	to	TO	TO	_	33	case	_	_
33	values	value	NNS	NNS	_	27	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	young	young	JJ	JJ	_	33	nmod	_	_
37	.	.	.	.	_	1	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	estrogen	estrogen	NN	NN	_	8	nsubj	_	_
8	modulates	modulate	VBZ	VBZ	_	5	dep	_	_
9	the	the	DT	DT	_	11	det	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	numbers	number	NNS	NNS	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	effects	effect	NNS	NNS	_	17	nsubjpass	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	8	conj	_	_
18	through	through	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	ER	er	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	monocytes	monocyte	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	10	nsubj	_	_
3	upstream	upstream	JJ	JJ	_	2	advmod	_	_
4	from	from	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	delta-globin-encoding	delta-globin-encoding	JJ	JJ	_	8	amod	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	specifically	specifically	RB	RB	_	10	advmod	_	_
10	enhances	enhance	VBZ	VBZ	_	0	root	_	_
11	beta-globin	beta-globin	JJ	JJ	_	13	amod	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	murine	murine	JJ	JJ	_	18	amod	_	_
17	erythroleukemia	erythroleukemia	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	20	nsubj	_	_
9	specific	specific	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	adult	adult	JJ	JJ	_	13	amod	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	polypryrimidine-binding	polypryrimidine-binding	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	8	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	PYBF	pybf	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	binds	bind	VBZ	VBZ	_	4	ccomp	_	_
21	to	to	TO	TO	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	pyrimidine-rich	pyrimidine-rich	JJ	JJ	_	24	amod	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	1	1	CD	CD	_	26	nummod	_	_
26	kb	kb	NN	NN	_	24	dep	_	_
27	upstream	upstream	JJ	JJ	_	26	amod	_	_
28	from	from	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	delta-globin-encoding	delta-globin-encoding	JJ	JJ	_	32	amod	_	_
32	gene	gene	NN	NN	_	26	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	HBD	hbd	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	developmental	developmental	JJ	JJ	_	3	amod	_	_
3	stage-specificity	stage-specificity	NN	NN	_	24	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	PYBF	pybf	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	the	the	DT	DT	_	8	det	_	_
8	location	location	NN	NN	_	3	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	site	site	NN	NN	_	8	nmod	_	_
13	between	between	IN	IN	_	23	case	_	_
14	the	the	DT	DT	_	23	det	_	_
15	fetal	fetal	JJ	JJ	_	23	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	adult	adult	JJ	JJ	_	15	conj	_	_
18	beta-globin	beta-globin	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	HBB	hbb	NN	NN	_	23	compound	_	_
21	)	)	-RRB-	-RRB-	_	23	punct	_	_
22	-like	-like	JJ	JJ	_	23	amod	_	_
23	genes	gene	NNS	NNS	_	12	nmod	_	_
24	suggest	suggest	VBP	VBP	_	0	root	_	_
25	that	that	IN	IN	_	32	mark	_	_
26	PBYF	pbyf	NN	NN	_	32	nsubj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
29	binding	bind	VBG	VBG	_	30	amod	_	_
30	site	site	NN	NN	_	26	conj	_	_
31	may	may	MD	MD	_	32	aux	_	_
32	function	function	VB	VB	_	24	ccomp	_	_
33	in	in	IN	IN	_	37	case	_	_
34	fetal-to-adult	fetal-to-adult	JJ	JJ	_	37	amod	_	_
35	globin	globin	NN	NN	_	36	compound	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	switching	switching	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	24	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	describe	describe	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	383-bp	383-bp	JJ	JJ	_	6	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	delta383	delta383	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	99-bp	99-bp	JJ	JJ	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	delta99	delta99	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	sequences	sequence	NNS	NNS	_	8	dep	_	_
18	containing	contain	VBG	VBG	_	8	acl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	PYBF-binding	pybf-binding	JJ	JJ	_	21	amod	_	_
21	site	site	NN	NN	_	18	dobj	_	_
22	on	on	IN	IN	_	23	case	_	_
23	transcription	transcription	NN	NN	_	6	nmod	_	_
24	from	from	IN	IN	_	26	case	_	_
25	various	various	JJ	JJ	_	26	amod	_	_
26	globin	globin	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	non-globin	non-globin	JJ	JJ	_	26	conj	_	_
29	promoters	promoter	NNS	NNS	_	26	dep	_	_
30	,	,	,	,	_	4	punct	_	_
31	using	use	VBG	VBG	_	4	advcl	_	_
32	a	a	DT	DT	_	34	det	_	_
33	transient	transient	JJ	JJ	_	34	amod	_	_
34	assay	assay	NN	NN	_	31	dobj	_	_
35	with	with	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	cat	cat	NN	NN	_	39	compound	_	_
38	reporter	reporter	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	34	nmod	_	_
40	in	in	IN	IN	_	46	case	_	_
41	murine	murine	JJ	JJ	_	46	amod	_	_
42	erythroleukemia	erythroleukemia	NN	NN	_	46	compound	_	_
43	(	(	-LRB-	-LRB-	_	46	punct	_	_
44	MEL	mel	NN	NN	_	46	compound	_	_
45	)	)	-RRB-	-RRB-	_	46	punct	_	_
46	cells	cell	NNS	NNS	_	39	nmod	_	_
47	,	,	,	,	_	46	punct	_	_
48	a	a	DT	DT	_	50	det	_	_
49	cell	cell	NN	NN	_	50	compound	_	_
50	line	line	NN	NN	_	46	appos	_	_
51	with	with	IN	IN	_	54	case	_	_
52	abundant	abundant	JJ	JJ	_	54	amod	_	_
53	PYBF	pybf	NN	NN	_	54	compound	_	_
54	activity	activity	NN	NN	_	50	nmod	_	_
55	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	delta383	delta383	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	delta99	delta99	NN	NN	_	5	conj	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	enhance	enhance	VBP	VBP	_	2	ccomp	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	cat	cat	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	14	case	_	_
14	plasmids	plasmid	NNS	NNS	_	10	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	a	a	DT	DT	_	23	det	_	_
17	human	human	JJ	JJ	_	23	amod	_	_
18	adult	adult	JJ	JJ	_	23	amod	_	_
19	globin	globin	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	HBB	hbb	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	promoter	promoter	NN	NN	_	15	dobj	_	_
24	,	,	,	,	_	9	punct	_	_
25	whereas	whereas	IN	IN	_	51	mark	_	_
26	expression	expression	NN	NN	_	51	nsubjpass	_	_
27	of	of	IN	IN	_	29	case	_	_
28	similar	similar	JJ	JJ	_	29	amod	_	_
29	constructs	construct	NNS	NNS	_	26	nmod	_	_
30	using	use	VBG	VBG	_	26	acl	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	fetal	fetal	JJ	JJ	_	37	compound	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	A	a	NN	NN	_	35	compound	_	_
35	gamma-	gamma-	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	globin	globin	NN	NN	_	30	dobj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	HBG1	hbg1	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	or	or	CC	CC	_	37	cc	_	_
42	simian	simian	JJ	JJ	_	43	amod	_	_
43	virus	virus	NN	NN	_	37	conj	_	_
44	40	40	CD	CD	_	43	nummod	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	SV40	sv40	NN	NN	_	43	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	promoters	promoter	NNS	NNS	_	37	dep	_	_
49	is	be	VBZ	VBZ	_	51	auxpass	_	_
50	not	not	RB	RB	_	51	neg	_	_
51	enhanced	enhance	VBN	VBN	_	9	advcl	_	_
52	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	PYBF	pybf	NN	NN	_	15	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	pyrimidine-rich	pyrimidine-rich	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	5	conj	_	_
10	upstream	upstream	JJ	JJ	_	9	advmod	_	_
11	from	from	IN	IN	_	12	case	_	_
12	HBD	hbd	NN	NN	_	10	nmod	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	specifically	specifically	RB	RB	_	15	advmod	_	_
15	enhance	enhance	VB	VB	_	3	ccomp	_	_
16	HBB	hbb	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	adult	adult	JJ	JJ	_	21	amod	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Rel-deficient	rel-deficient	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	exhibit	exhibit	VBP	VBP	_	0	root	_	_
5	defects	defect	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	production	production	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	interleukin	interleukin	NN	NN	_	7	nmod	_	_
10	3	3	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	14	amod	_	_
13	colony-stimulating	colony-stimulating	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	9	conj	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	c-rel	c-rel	NN	NN	_	3	compound	_	_
3	protooncogene	protooncogene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subunit	subunit	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
10	B-like	b-like	JJ	JJ	_	14	amod	_	_
11	family	family	NN	NN	_	14	compound	_	_
12	of	of	IN	IN	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Mice	mouse	NNS	NNS	_	5	nsubj	_	_
2	lacking	lack	VBG	VBG	_	1	acl	_	_
3	Rel	rel	NN	NN	_	2	dobj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	defective	defective	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	mitogenic	mitogenic	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	B	b	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	10	conj	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	dep	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	display	display	VBP	VBP	_	5	conj	_	_
16	impaired	impaired	JJ	JJ	_	18	amod	_	_
17	humoral	humoral	JJ	JJ	_	18	amod	_	_
18	immunity	immunity	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	attempt	attempt	NN	NN	_	25	nmod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	identify	identify	VB	VB	_	3	acl	_	_
6	changes	change	NNS	NNS	_	5	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	accompany	accompany	VBP	VBP	_	6	acl:relcl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	T-cell	t-cell	NN	NN	_	15	compound	_	_
14	stimulation	stimulation	NN	NN	_	15	compound	_	_
15	defects	defect	NNS	NNS	_	11	dobj	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	loss	loss	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Rel	rel	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	we	we	PRP	PRP	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	examined	examine	VBN	VBN	_	0	root	_	_
26	the	the	DT	DT	_	27	det	_	_
27	expression	expression	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	cell	cell	NN	NN	_	32	compound	_	_
30	surface	surface	NN	NN	_	32	compound	_	_
31	activation	activation	NN	NN	_	32	compound	_	_
32	markers	marker	NNS	NNS	_	27	nmod	_	_
33	and	and	CC	CC	_	27	cc	_	_
34	cytokine	cytokine	NN	NN	_	35	compound	_	_
35	production	production	NN	NN	_	27	conj	_	_
36	in	in	IN	IN	_	40	case	_	_
37	mitogen-stimulated	mitogen-stimulated	JJ	JJ	_	40	amod	_	_
38	Rel-/-	rel-/-	JJ	JJ	_	40	amod	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	29	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	markers	marker	NNS	NNS	_	2	nmod	_	_
7	including	include	VBG	VBG	_	17	case	_	_
8	the	the	DT	DT	_	17	det	_	_
9	interleukin	interleukin	NN	NN	_	17	compound	_	_
10	2	2	CD	CD	_	17	nummod	_	_
11	receptor	receptor	NN	NN	_	17	compound	_	_
12	alpha	alpha	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	IL-2R	il-2r	NN	NN	_	17	compound	_	_
15	alpha	alpha	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	chain	chain	NN	NN	_	6	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CD25	cd25	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	17	punct	_	_
22	CD69	cd69	NN	NN	_	17	conj	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	L-selectin	l-selectin	NN	NN	_	17	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CD62	cd62	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	normal	normal	JJ	JJ	_	0	root	_	_
30	in	in	IN	IN	_	34	case	_	_
31	mitogen-activated	mitogen-activated	JJ	JJ	_	34	amod	_	_
32	Rel-/-	rel-/-	JJ	JJ	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	,	,	,	,	_	29	punct	_	_
36	but	but	CC	CC	_	29	cc	_	_
37	cytokine	cytokine	NN	NN	_	38	compound	_	_
38	production	production	NN	NN	_	40	nsubj	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	impaired	impaired	JJ	JJ	_	29	conj	_	_
41	.	.	.	.	_	29	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	Rel-/-	rel-/-	JJ	JJ	_	6	amod	_	_
3	splenic	splenic	JJ	JJ	_	6	amod	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	cultures	culture	NNS	NNS	_	48	nmod	_	_
7	stimulated	stimulate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	phorbol	phorbol	NN	NN	_	11	compound	_	_
10	12-myristate	12-myristate	NN	NN	_	11	compound	_	_
11	13-acetate	13-acetate	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	ionomycin	ionomycin	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	48	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	levels	level	NNS	NNS	_	48	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IL-3	il-3	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	IL-5	il-5	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	24	amod	_	_
23	colony-stimulating	colony-stimulating	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	18	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	GM-CSF	gm-csf	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	18	punct	_	_
29	tumor	tumor	NN	NN	_	32	compound	_	_
30	necrosis	necrosis	NN	NN	_	32	compound	_	_
31	factor	factor	NN	NN	_	32	compound	_	_
32	alpha	alpha	NN	NN	_	18	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	TNF-alpha	tnf-alpha	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	18	punct	_	_
37	and	and	CC	CC	_	18	cc	_	_
38	gamma	gamma	NN	NN	_	39	compound	_	_
39	interferon	interferon	NN	NN	_	18	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	IFN-gamma	ifn-gamma	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	were	be	VBD	VBD	_	48	cop	_	_
44	only	only	RB	RB	_	45	advmod	_	_
45	2-	2-	CD	CD	_	48	nmod:npmod	_	_
46	to	to	TO	TO	_	45	dep	_	_
47	3-fold	3-fold	RB	RB	_	45	advmod	_	_
48	lower	lower	JJR	JJR	_	0	root	_	_
49	compared	compare	VBN	VBN	_	53	case	_	_
50	with	with	IN	IN	_	53	case	_	_
51	normal	normal	JJ	JJ	_	53	amod	_	_
52	T	t	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	48	advcl	_	_
54	.	.	.	.	_	48	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	anti-CD3	anti-cd3	JJ	JJ	_	10	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	anti-CD28	anti-cd28	JJ	JJ	_	4	conj	_	_
7	stimulated	stimulated	JJ	JJ	_	4	dep	_	_
8	Rel-/-	rel-/-	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	17	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	fail	fail	VBP	VBP	_	10	acl:relcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	proliferate	proliferate	VB	VB	_	13	xcomp	_	_
16	,	,	,	,	_	10	punct	_	_
17	make	make	VBP	VBP	_	0	root	_	_
18	little	little	JJ	JJ	_	17	dobj	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	no	no	DT	DT	_	18	conj	_	_
21	detectable	detectable	JJ	JJ	_	22	amod	_	_
22	cytokines	cytokine	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	17	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	2	amod	_	_
2	IL-2	il-2	NN	NN	_	18	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	restitutes	restitute	VBZ	VBZ	_	2	acl:relcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	proliferative	proliferative	JJ	JJ	_	8	amod	_	_
8	response	response	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	anti-CD3-	anti-cd3-	JJ	JJ	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	anti-CD28-treated	anti-cd28-treated	JJ	JJ	_	11	conj	_	_
14	Rel-/-	rel-/-	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	dep	_	_
17	,	,	,	,	_	2	punct	_	_
18	restores	restore	VBZ	VBZ	_	0	root	_	_
19	production	production	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-5	il-5	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	IFN-gamma	ifn-gamma	NN	NN	_	21	conj	_	_
27	,	,	,	,	_	19	punct	_	_
28	but	but	CC	CC	_	29	cc	_	_
29	not	not	RB	RB	_	19	cc	_	_
30	IL-3	il-3	NN	NN	_	19	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	GM-CSF	gm-csf	NN	NN	_	30	conj	_	_
33	expression	expression	NN	NN	_	30	dep	_	_
34	to	to	TO	TO	_	37	case	_	_
35	approximately	approximately	RB	RB	_	36	advmod	_	_
36	normal	normal	JJ	JJ	_	37	amod	_	_
37	levels	level	NNS	NNS	_	18	nmod	_	_
38	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	to	to	TO	TO	_	7	case	_	_
4	mitogen-activated	mitogen-activated	JJ	JJ	_	7	amod	_	_
5	Rel-/-	rel-/-	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	11	amod	_	_
10	Rel-/-	rel-/-	JJ	JJ	_	11	amod	_	_
11	macrophages	macrophage	NNS	NNS	_	12	nsubj	_	_
12	produce	produce	VBP	VBP	_	0	root	_	_
13	higher	higher	JJR	JJR	_	12	dobj	_	_
14	than	than	IN	IN	_	15	case	_	_
15	normal	normal	JJ	JJ	_	13	nmod	_	_
16	levels	level	NNS	NNS	_	13	dep	_	_
17	of	of	IN	IN	_	18	case	_	_
18	GM-CSF	gm-csf	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Rel	rel	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	function	function	VB	VB	_	3	ccomp	_	_
8	as	as	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	dep	_	_
10	activator	activator	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	repressor	repressor	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	7	conj	_	_
19	by	by	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
22	for	for	IN	IN	_	23	case	_	_
23	production	production	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	IL-3	il-3	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	GM-CSF	gm-csf	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	2	nsubj	_	_
2	modulates	modulate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	AP-1	ap-1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	conj	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	dep	_	_
13	mRNA	mrna	NN	NN	_	2	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	protein	protein	NN	NN	_	13	conj	_	_
16	level	level	NN	NN	_	13	dep	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	modulates	modulate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	level	level	NN	NN	_	5	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	view	view	NN	NN	_	8	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	analyzed	analyze	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IFN-gamma	ifn-gamma	NN	NN	_	10	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	different	different	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	activated	activate	VBN	VBN	_	23	amod	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Priming	priming	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	down	down	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	c-fos	c-fos	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-jun	c-jun	NN	NN	_	13	conj	_	_
16	mRNA	mrna	NN	NN	_	13	dep	_	_
17	in	in	IN	IN	_	18	case	_	_
18	response	response	NN	NN	_	11	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	stimulation	stimulation	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	lipopolysaccharide	lipopolysaccharide	NN	NN	_	20	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	LPS	lps	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	compared	compare	VBN	VBN	_	29	case	_	_
27	to	to	TO	TO	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	effects	effect	NNS	NNS	_	11	acl	_	_
30	of	of	IN	IN	_	31	case	_	_
31	LPS	lps	NN	NN	_	29	nmod	_	_
32	alone	alone	RB	RB	_	31	advmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Not	not	RB	RB	_	2	neg	_	_
2	only	only	RB	RB	_	6	dep	_	_
3	was	be	VBD	VBD	_	6	auxpass	_	_
4	this	this	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	6	nsubjpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	at	at	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	level	level	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	activator	activator	NN	NN	_	14	compound	_	_
14	protein-1	protein-1	NN	NN	_	20	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	AP-1	ap-1	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	capacity	capacity	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	affected	affect	VBN	VBN	_	6	conj	_	_
23	as	as	RB	RB	_	22	advmod	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	,	,	.	.	_	6	punct	_	_
26	A	a	DT	DT	_	28	det	_	_
27	strong	strong	JJ	JJ	_	28	amod	_	_
28	reduction	reduction	NN	NN	_	30	nsubjpass	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	observed	observe	VBN	VBN	_	6	parataxis	_	_
31	in	in	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	LPS-induced	lps-induced	JJ	JJ	_	35	amod	_	_
34	DNA-binding	dna-binding	JJ	JJ	_	35	amod	_	_
35	activity	activity	NN	NN	_	30	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	AP-1	ap-1	NN	NN	_	35	nmod	_	_
38	in	in	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	presence	presence	NN	NN	_	30	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	IFN-gamma	ifn-gamma	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	6	punct	_	_

1	LPS-stimulated	lps-stimulated	JJ	JJ	_	2	amod	_	_
2	monocytes	monocyte	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	increased	increase	VBN	VBN	_	6	amod	_	_
6	expression	expression	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	p105	p105	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	precursor	precursor	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	p50	p50	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	transcription	transcription	NN	NN	_	23	compound	_	_
20	factor	factor	NN	NN	_	23	compound	_	_
21	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
22	factor-kappa	factor-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	16	nmod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	3	punct	_	_
29	while	while	IN	IN	_	33	mark	_	_
30	no	no	DT	DT	_	31	neg	_	_
31	effect	effect	NN	NN	_	33	nsubjpass	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	noticed	notice	VBN	VBN	_	3	advcl	_	_
34	on	on	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	expression	expression	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	p65	p65	NN	NN	_	39	compound	_	_
39	mRNA	mrna	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	IFN-gamma	ifn-gamma	NN	NN	_	5	compound	_	_
5	priming	priming	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	affect	affect	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	p105	p105	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	10	nmod	_	_
14	but	but	CC	CC	_	8	cc	_	_
15	enhanced	enhance	VBD	VBD	_	8	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	p65	p65	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	two-fold	two-fold	RB	RB	_	15	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	8	punct	_	_

1	Priming	prime	VBG	VBG	_	8	csubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
4	followed	follow	VBN	VBN	_	1	dep	_	_
5	by	by	IN	IN	_	7	case	_	_
6	LPS	lps	NN	NN	_	7	compound	_	_
7	stimulation	stimulation	NN	NN	_	4	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	further	further	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	p65	p65	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	due	due	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	an	a	DT	DT	_	6	det	_	_
6	increase	increase	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	half-life	half-life	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	p65	p65	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	75	75	CD	CD	_	9	dep	_	_
15	vs	vs	CC	CC	_	14	cc	_	_
16	150	150	CD	CD	_	14	conj	_	_
17	minutes	minute	NNS	NNS	_	14	dep	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	VB	VB	_	4	dep	_	_
4	assays	assay	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSAs	emsa	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	unstimulated	unstimulated	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	13	nsubj	_	_
12	predominantly	predominantly	RB	RB	_	13	advmod	_	_
13	expressed	express	VBD	VBD	_	8	ccomp	_	_
14	p50	p50	NN	NN	_	13	dobj	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	14	dep	_	_
17	.	.	.	.	_	8	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	LPS	lps	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	IFN-gamma	ifn-gamma	NN	NN	_	3	conj	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	p50	p50	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p65	p65	NN	NN	_	14	compound	_	_
14	subunits	subunit	NNS	NNS	_	11	conj	_	_
15	,	,	,	,	_	6	punct	_	_
16	while	while	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	combination	combination	NN	NN	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	18	nmod	_	_
21	plus	plus	CC	CC	_	20	cc	_	_
22	LPS	lps	NN	NN	_	20	conj	_	_
23	caused	cause	VBD	VBD	_	6	advcl	_	_
24	a	a	DT	DT	_	26	det	_	_
25	further	further	JJ	JJ	_	26	amod	_	_
26	increase	increase	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	expression	expression	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	With	with	IN	IN	_	3	case	_	_
2	Western	western	NN	NN	_	3	compound	_	_
3	blotting	blotting	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	it	it	PRP	PRP	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	extracts	extract	NNS	NNS	_	13	nsubj	_	_
11	from	from	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	contained	contain	VBD	VBD	_	7	ccomp	_	_
14	p50	p50	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	p65	p65	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	14	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	response	response	NN	NN	_	13	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	LPS	lps	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	21	conj	_	_
24	stimulation	stimulation	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	combined	combined	JJ	JJ	_	5	amod	_	_
5	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	result	result	VB	VB	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	enhanced	enhance	VBN	VBN	_	11	amod	_	_
11	p50	p50	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p65	p65	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	11	conj	_	_
15	expression	expression	NN	NN	_	11	dep	_	_
16	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IFN-gamma	ifn-gamma	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	2	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	specific	specific	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	since	since	IN	IN	_	16	mark	_	_
13	no	no	DT	DT	_	14	neg	_	_
14	change	change	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	10	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF-IL-6	nf-il-6	NN	NN	_	19	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	I	i	NN	NN	_	26	compound	_	_
24	kappa	kappa	NN	NN	_	26	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	21	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	inhibitor	inhibitor	NN	NN	_	26	appos	_	_
30	of	of	IN	IN	_	32	case	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	21	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	21	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	AP-1	ap-1	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	conj	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	important	important	JJ	JJ	_	2	ccomp	_	_
22	for	for	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	modulatory	modulatory	JJ	JJ	_	25	amod	_	_
25	effects	effect	NNS	NNS	_	21	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	IFN-gamma	ifn-gamma	NN	NN	_	25	nmod	_	_
28	on	on	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	cytokine	cytokine	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	25	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	activated	activate	VBN	VBN	_	35	amod	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	monocytes	monocyte	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	c-fos	c-fos	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	c-jun	c-jun	NN	NN	_	3	conj	_	_
6	proteins	protein	NNS	NNS	_	1	nmod	_	_
7	and	and	CC	CC	_	1	cc	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	1	conj	_	_
11	during	during	IN	IN	_	14	case	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	cycle	cycle	NN	NN	_	14	compound	_	_
14	progression	progression	NN	NN	_	1	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HL60	hl60	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	phytohemagglutinin-stimulated	phytohemagglutinin-stimulated	JJ	JJ	_	20	amod	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	products	product	NNS	NNS	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	c-fos	c-fos	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	p62c-fos	p62c-fos	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	c-jun	c-jun	NN	NN	_	6	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	p39c-jun	p39c-jun	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	genes	gene	NNS	NNS	_	6	dep	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	members	member	NNS	NNS	_	0	root	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	AP-1	ap-1	NN	NN	_	23	compound	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	family	family	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	thought	think	VBN	VBN	_	17	conj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	play	play	VB	VB	_	26	xcomp	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	roles	role	NNS	NNS	_	28	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	regulation	regulation	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	33	nmod	_	_
37	during	during	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	cycle	cycle	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	17	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	studies	study	NNS	NNS	_	17	nsubjpass	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	relation	relation	NN	NN	_	2	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	cycle	cycle	NN	NN	_	10	nmod	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	performed	perform	VBN	VBN	_	0	root	_	_
18	at	at	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	level	level	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	therefore	therefore	RB	RB	_	27	advmod	_	_
25	do	do	VB	VB	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	give	give	VB	VB	_	17	conj	_	_
28	direct	direct	JJ	JJ	_	29	amod	_	_
29	information	information	NN	NN	_	27	dobj	_	_
30	about	about	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	presence	presence	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	proteins	protein	NNS	NNS	_	32	nmod	_	_
36	during	during	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	cycle	cycle	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	Western	western	NN	NN	_	5	compound	_	_
5	blotting	blotting	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	investigate	investigate	VB	VB	_	3	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	presence	presence	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	proteins	protein	NNS	NNS	_	9	nmod	_	_
13	during	during	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	cycles	cycle	NNS	NNS	_	9	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	different	different	JJ	JJ	_	21	amod	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	systems	system	NNS	NNS	_	16	nmod	_	_
22	:	:	:	:	_	3	punct	_	_
23	a	a	DT	DT	_	29	det	_	_
24	continuously	continuously	RB	RB	_	29	advmod	_	_
25	growing	grow	VBG	VBG	_	29	amod	_	_
26	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
27	leukemic	leukemic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	3	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	HL60	hl60	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	normal	normal	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	29	conj	_	_
36	stimulated	stimulate	VBN	VBN	_	35	acl	_	_
37	into	into	IN	IN	_	38	case	_	_
38	cycle	cycle	NN	NN	_	36	nmod	_	_
39	,	,	,	,	_	35	punct	_	_
40	phyto-hemagglutinin	phyto-hemagglutinin	NN	NN	_	49	compound	_	_
41	(	(	-LRB-	-LRB-	_	49	punct	_	_
42	PHA	pha	NN	NN	_	49	compound	_	_
43	)	)	-RRB-	-RRB-	_	49	punct	_	_
44	-stimulated	-stimulated	JJ	JJ	_	49	amod	_	_
45	normal	normal	JJ	JJ	_	49	amod	_	_
46	human	human	JJ	JJ	_	49	amod	_	_
47	peripheral	peripheral	JJ	JJ	_	49	amod	_	_
48	blood	blood	NN	NN	_	49	compound	_	_
49	lymphocytes	lymphocyte	NNS	NNS	_	35	appos	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	PBL	pbl	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	3	nmod	_	_
7	AP-1	ap-1	NN	NN	_	6	dep	_	_
8	,	,	,	,	_	6	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	consists	consist	VBZ	VBZ	_	6	acl:relcl	_	_
11	of	of	IN	IN	_	12	case	_	_
12	dimers	dimer	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Fos	fos	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Jun	jun	NN	NN	_	14	conj	_	_
17	family	family	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	14	dep	_	_
19	,	,	,	,	_	3	punct	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	studied	study	VBN	VBN	_	0	root	_	_
23	using	use	VBG	VBG	_	22	xcomp	_	_
24	a	a	DT	DT	_	27	det	_	_
25	gel	gel	NN	NN	_	27	compound	_	_
26	shift	shift	NN	NN	_	27	compound	_	_
27	assay	assay	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
4	p62c-fos	p62c-fos	NN	NN	_	11	compound	_	_
5	,	,	,	,	_	4	punct	_	_
6	p39c-jun	p39c-jun	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	AP-1	ap-1	NN	NN	_	4	conj	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	2	dobj	_	_
12	throughout	throughout	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	cycle	cycle	NN	NN	_	2	nmod	_	_
16	both	both	CC	CC	_	19	cc:preconj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	HL60	hl60	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	in	in	IN	IN	_	23	case	_	_
22	PHA-stimulated	pha-stimulated	JJ	JJ	_	23	amod	_	_
23	PBL	pbl	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	2	punct	_	_
25	and	and	CC	CC	_	2	cc	_	_
26	we	we	PRP	PRP	_	27	nsubj	_	_
27	postulate	postulate	VBP	VBP	_	2	conj	_	_
28	that	that	IN	IN	_	32	mark	_	_
29	these	these	DT	DT	_	30	det	_	_
30	proteins	protein	NNS	NNS	_	32	nsubjpass	_	_
31	are	be	VBP	VBP	_	32	auxpass	_	_
32	required	require	VBN	VBN	_	27	ccomp	_	_
33	throughout	throughout	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	cycle	cycle	NN	NN	_	39	nmod	_	_
37	and	and	CC	CC	_	39	cc	_	_
38	not	not	RB	RB	_	39	conj	_	_
39	transiently	transiently	RB	RB	_	32	nmod	_	_
40	in	in	IN	IN	_	45	case	_	_
41	the	the	DT	DT	_	45	det	_	_
42	G0	g0	NN	NN	_	45	compound	_	_
43	to	to	TO	TO	_	44	case	_	_
44	G1	g1	NN	NN	_	42	nmod	_	_
45	transition	transition	NN	NN	_	51	nmod	_	_
46	as	as	IN	IN	_	51	mark	_	_
47	previous	previous	JJ	JJ	_	49	amod	_	_
48	mRNA	mrna	NN	NN	_	49	compound	_	_
49	studies	study	NNS	NNS	_	51	nsubj	_	_
50	have	have	VBP	VBP	_	51	aux	_	_
51	indicated	indicate	VBN	VBN	_	39	nmod	_	_
52	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	uncoupling	uncoupling	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	AP-1	ap-1	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	p62c-fos	p62c-fos	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	p39c-jun	p39c-jun	NN	NN	_	15	compound	_	_
14	AP-1	ap-1	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	4	conj	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	strongly	strongly	RB	RB	_	17	advmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	G1-	g1-	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	G2/M-phase	g2/m-phase	NN	NN	_	22	conj	_	_
25	enriched	enriched	JJ	JJ	_	26	amod	_	_
26	samples	sample	NNS	NNS	_	22	dep	_	_
27	than	than	IN	IN	_	32	case	_	_
28	in	in	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	S-phase	s-phase	NN	NN	_	32	compound	_	_
31	enriched	enriched	JJ	JJ	_	32	amod	_	_
32	samples	sample	NNS	NNS	_	19	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	HL60	hl60	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	,	,	,	,	_	17	punct	_	_
37	while	while	IN	IN	_	45	mark	_	_
38	levels	level	NNS	NNS	_	45	nsubj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	nuclear	nuclear	JJ	JJ	_	41	amod	_	_
41	p62c-fos	p62c-fos	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	p39c-jun	p39c-jun	NN	NN	_	41	conj	_	_
44	were	be	VBD	VBD	_	45	cop	_	_
45	constant	constant	JJ	JJ	_	17	advcl	_	_
46	.	.	.	.	_	2	punct	_	_

1	Nuclei	nucleus	NNS	NNS	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	unstimulated	unstimulated	JJ	JJ	_	4	amod	_	_
4	PBL	pbl	NN	NN	_	1	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	different	different	JJ	JJ	_	7	amod	_	_
7	donors	donor	NNS	NNS	_	4	nmod	_	_
8	expressed	express	VBD	VBD	_	0	root	_	_
9	p62c-fos	p62c-fos	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p39c-jun	p39c-jun	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	but	but	CC	CC	_	8	cc	_	_
14	AP-1	ap-1	NN	NN	_	17	nsubjpass	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	detected	detect	VBN	VBN	_	8	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	majority	majority	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	samples	sample	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	PHA	pha	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	13	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	PBL	pbl	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	increase	increase	NN	NN	_	13	nsubjpass	_	_
9	in	in	IN	IN	_	11	case	_	_
10	AP-1	ap-1	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	delayed	delay	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	15	case	_	_
15	respect	respect	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	augmentation	augmentation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	p39c-jun	p39c-jun	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	cytoplasmic	cytoplasmic	JJ	JJ	_	6	amod	_	_
6	p62c-fos	p62c-fos	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p39c-jun	p39c-jun	NN	NN	_	6	conj	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	present	present	JJ	JJ	_	3	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HL60	hl60	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	PHA-stimulated	pha-stimulated	JJ	JJ	_	16	amod	_	_
16	PBL	pbl	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	cytoplasmic	cytoplasmic	JJ	JJ	_	5	amod	_	_
5	p62c-fos	p62c-fos	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	unstimulated	unstimulated	JJ	JJ	_	10	amod	_	_
10	PBL	pbl	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	although	although	IN	IN	_	19	mark	_	_
13	in	in	IN	IN	_	15	case	_	_
14	some	some	DT	DT	_	15	det	_	_
15	cases	case	NNS	NNS	_	19	nmod	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
17	p39c-jun	p39c-jun	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	detected	detect	VBN	VBN	_	7	advcl	_	_
20	,	,	,	,	_	7	punct	_	_
21	suggesting	suggest	VBG	VBG	_	7	xcomp	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	subcellular	subcellular	JJ	JJ	_	24	amod	_	_
24	compartmentalization	compartmentalization	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	proteins	protein	NNS	NNS	_	24	nmod	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	occur	occur	VB	VB	_	21	ccomp	_	_
30	under	under	IN	IN	_	32	case	_	_
31	certain	certain	JJ	JJ	_	32	amod	_	_
32	circumstances	circumstance	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Second	second	JJ	JJ	_	3	amod	_	_
2	messenger	messenger	NN	NN	_	3	compound	_	_
3	up-regulation	up-regulation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	androgen	androgen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	absent	absent	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	18	case	_	_
12	androgen	androgen	NN	NN	_	18	compound	_	_
13	insensitive	insensitive	JJ	JJ	_	18	amod	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	prostatic	prostatic	JJ	JJ	_	18	amod	_	_
16	carcinoma	carcinoma	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	10	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	PC-3	pc-3	NN	NN	_	18	appos	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	DU-145	du-145	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	theoretical	theoretical	JJ	JJ	_	3	amod	_	_
3	pathway	pathway	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	regulation	regulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	androgen	androgen	NN	NN	_	14	compound	_	_
10	receptor	receptor	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	AR	ar	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	gene	gene	NN	NN	_	6	nmod	_	_
15	is	be	VBZ	VBZ	_	20	cop	_	_
16	via	via	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	cAMP	camp	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	0	root	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CRE	cre	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	present	present	JJ	JJ	_	20	amod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	promoter	promoter	NN	NN	_	28	compound	_	_
28	region	region	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	-508	-508	CD	CD	_	32	compound	_	_
31	to	to	TO	TO	_	32	dep	_	_
32	-501	-501	CD	CD	_	28	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	20	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	20	20	CD	CD	_	3	nummod	_	_
3	h	h	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	stimulation	stimulation	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	8-bromo-cAMP	8-bromo-camp	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	AR	ar	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	upregulated	upregulate	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	LNCaP	lncap	NN	NN	_	12	nmod	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	19	neg	_	_
17	in	in	IN	IN	_	19	case	_	_
18	either	either	CC	CC	_	19	cc:preconj	_	_
19	PC-3	pc-3	NN	NN	_	14	conj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	DU-145	du-145	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	19	conj	_	_
24	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	level	level	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	CRE	cre	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CREB	creb	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	the	the	DT	DT	_	16	det	_	_
16	same	same	JJ	JJ	_	3	ccomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	all	all	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	putative	putative	JJ	JJ	_	25	amod	_	_
25	AR-CRE	ar-cre	NN	NN	_	26	nsubj	_	_
26	forms	form	VBZ	VBZ	_	16	conj	_	_
27	specific	specific	JJ	JJ	_	31	amod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	compatible	compatible	JJ	JJ	_	27	conj	_	_
30	protein	protein	NN	NN	_	31	compound	_	_
31	interactions	interaction	NNS	NNS	_	26	dobj	_	_
32	with	with	IN	IN	_	33	case	_	_
33	CREB	creb	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	14	nsubjpass	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	regulate	regulate	VB	VB	_	2	acl	_	_
5	AR	ar	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	transcription	transcription	NN	NN	_	4	dobj	_	_
8	via	via	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	second	second	JJ	JJ	_	12	amod	_	_
11	messenger	messenger	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	lost	lose	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	PC-3	pc-3	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	DU-145	du-145	NN	NN	_	17	conj	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	17	dep	_	_
22	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	7	nsubj	_	_
2	may	may	MD	MD	_	7	aux	_	_
3	be	be	VB	VB	_	7	cop	_	_
4	an	a	DT	DT	_	7	det	_	_
5	important	important	JJ	JJ	_	7	amod	_	_
6	primary	primary	JJ	JJ	_	5	dep	_	_
7	mechanism	mechanism	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	10	case	_	_
9	androgen	androgen	NN	NN	_	10	compound	_	_
10	insensitivity	insensitivity	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	prostate	prostate	NN	NN	_	13	compound	_	_
13	cancer	cancer	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Soluble	soluble	JJ	JJ	_	5	amod	_	_
2	tumor	tumor	NN	NN	_	5	compound	_	_
3	necrosis	necrosis	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	6	nsubj	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	phorbol	phorbol	NN	NN	_	9	compound	_	_
8	myristate	myristate	NN	NN	_	9	compound	_	_
9	acetate	acetate	NN	NN	_	6	iobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cytokine-induced	cytokine-induced	JJ	JJ	_	13	amod	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	conj	_	_
14	chronically	chronically	RB	RB	_	17	advmod	_	_
15	infected	infected	JJ	JJ	_	17	amod	_	_
16	U1	u1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	6	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	10	amod	_	_
2	human	human	JJ	JJ	_	10	amod	_	_
3	tumor	tumor	NN	NN	_	10	compound	_	_
4	necrosis	necrosis	NN	NN	_	10	compound	_	_
5	factor	factor	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	TNF	tnf	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein-1	protein-1	NN	NN	_	29	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	r-h	r-h	JJ	JJ	_	13	amod	_	_
13	TBP-1	tbp-1	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	recombinant	recombinant	JJ	JJ	_	21	amod	_	_
17	human	human	JJ	JJ	_	21	amod	_	_
18	soluble	soluble	JJ	JJ	_	21	amod	_	_
19	dimeric	dimeric	JJ	JJ	_	21	amod	_	_
20	TNF	tnf	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	10	conj	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	rhu	rhu	JJ	JJ	_	26	amod	_	_
24	TNFR	tnfr	NN	NN	_	26	compound	_	_
25	:	:	:	:	_	26	punct	_	_
26	Fc	fc	NN	NN	_	21	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	used	use	VBN	VBN	_	0	root	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	determine	determine	VB	VB	_	29	xcomp	_	_
32	the	the	DT	DT	_	34	det	_	_
33	relative	relative	JJ	JJ	_	34	amod	_	_
34	contributions	contribution	NNS	NNS	_	31	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	TNF	tnf	NN	NN	_	34	nmod	_	_
37	to	to	TO	TO	_	54	case	_	_
38	phorbol	phorbol	NN	NN	_	40	compound	_	_
39	myristate	myristate	NN	NN	_	40	compound	_	_
40	acetate	acetate	NN	NN	_	54	amod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	PMA	pma	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	cytokine-induced	cytokine-induced	JJ	JJ	_	40	conj	_	_
46	human	human	JJ	JJ	_	49	amod	_	_
47	immunodeficiency	immunodeficiency	NN	NN	_	49	compound	_	_
48	virus	virus	NN	NN	_	49	compound	_	_
49	type	type	NN	NN	_	54	compound	_	_
50	1	1	CD	CD	_	49	nummod	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	HIV-1	hiv-1	NN	NN	_	49	appos	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	replication	replication	NN	NN	_	34	nmod	_	_
55	in	in	IN	IN	_	59	case	_	_
56	chronically	chronically	RB	RB	_	57	advmod	_	_
57	infected	infected	JJ	JJ	_	59	amod	_	_
58	cell	cell	NN	NN	_	59	compound	_	_
59	lines	line	NNS	NNS	_	54	nmod	_	_
60	.	.	.	.	_	29	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	HIV-1-infected	hiv-1-infected	JJ	JJ	_	6	amod	_	_
4	promonocytic	promonocytic	JJ	JJ	_	6	amod	_	_
5	U1	u1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	r-h-TBP-1	r-h-tbp-1	NN	NN	_	1	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	rhu	rhu	JJ	JJ	_	13	amod	_	_
11	TNFR	tnfr	NN	NN	_	13	compound	_	_
12	:	:	:	:	_	13	punct	_	_
13	Fc	fc	NN	NN	_	8	conj	_	_
14	reduced	reduce	VBD	VBD	_	0	root	_	_
15	PMA-induced	pma-induced	JJ	JJ	_	19	amod	_	_
16	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
17	p24	p24	NN	NN	_	18	compound	_	_
18	antigen	antigen	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	14	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	concentration-dependent	concentration-dependent	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	14	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	with	with	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	maximal	maximal	JJ	JJ	_	28	amod	_	_
28	inhibition	inhibition	NN	NN	_	14	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	approximately	approximately	RB	RB	_	31	advmod	_	_
31	90	90	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Maximal	maximal	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	p24	p24	NN	NN	_	5	compound	_	_
5	antigen	antigen	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	T-lymphocytic	t-lymphocytic	JJ	JJ	_	10	amod	_	_
9	ACH-2	ach-2	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	47	47	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	0	root	_	_
14	with	with	IN	IN	_	15	case	_	_
15	r-hTBP-1	r-htbp-1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	42	42	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	13	conj	_	_
19	with	with	IN	IN	_	23	case	_	_
20	rhu	rhu	JJ	JJ	_	23	amod	_	_
21	TNFR	tnfr	NN	NN	_	23	compound	_	_
22	:	:	:	:	_	23	punct	_	_
23	Fc	fc	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	r-hTBP-1	r-htbp-1	NN	NN	_	8	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	rhu	rhu	NN	NN	_	6	compound	_	_
4	TNFR	tnfr	NN	NN	_	6	compound	_	_
5	:	:	:	:	_	6	punct	_	_
6	Fc	fc	NN	NN	_	1	conj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	decreased	decrease	VBD	VBD	_	0	root	_	_
9	p24	p24	NN	NN	_	10	compound	_	_
10	antigen	antigen	NN	NN	_	8	dobj	_	_
11	synthesized	synthesize	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	U1	u1	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	response	response	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	stimuli	stimulus	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	27	case	_	_
22	phytohemagglutinin	phytohemagglutinin	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	PHA	pha	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	-induced	-induced	JJ	JJ	_	27	amod	_	_
27	supernatant	supernatant	NN	NN	_	19	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	31	amod	_	_
30	colony-stimulating	colony-stimulating	JJ	JJ	_	31	amod	_	_
31	factor	factor	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	interleukin-6	interleukin-6	NN	NN	_	27	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	and	and	CC	CC	_	27	cc	_	_
36	TNF	tnf	NN	NN	_	27	conj	_	_
37	.	.	.	.	_	8	punct	_	_

1	Addition	addition	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	r-hTBP-1	r-htbp-1	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	U1	u1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	during	during	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	last	last	JJ	JJ	_	11	amod	_	_
10	4	4	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	24	24	CD	CD	_	16	nummod	_	_
15	h	h	NN	NN	_	16	compound	_	_
16	incubation	incubation	NN	NN	_	11	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	PMA	pma	NN	NN	_	16	nmod	_	_
19	still	still	RB	RB	_	20	advmod	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	p24	p24	NN	NN	_	22	compound	_	_
22	antigen	antigen	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	20	dobj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	15	15	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	20	punct	_	_

1	U1	u1	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	8	nsubj	_	_
3	stimulated	stimulate	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	7	case	_	_
5	10(-7)	10(-7)	CD	CD	_	6	compound	_	_
6	M	m	NN	NN	_	7	amod	_	_
7	PMA	pma	NN	NN	_	3	nmod	_	_
8	released	release	VBD	VBD	_	0	root	_	_
9	approximately	approximately	RB	RB	_	10	advmod	_	_
10	1	1	CD	CD	_	11	dep	_	_
11	ng/ml	ng/ml	NN	NN	_	13	dep	_	_
12	endogenous	endogenous	JJ	JJ	_	13	amod	_	_
13	TBP-1	tbp-1	NN	NN	_	8	dobj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	initial	initial	JJ	JJ	_	17	amod	_	_
17	peak	peak	NN	NN	_	8	nmod	_	_
18	observed	observe	VBN	VBN	_	17	acl	_	_
19	at	at	IN	IN	_	21	case	_	_
20	1	1	CD	CD	_	21	nummod	_	_
21	h	h	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	a	a	DT	DT	_	25	det	_	_
24	second	second	JJ	JJ	_	25	amod	_	_
25	peak	peak	NN	NN	_	17	conj	_	_
26	at	at	IN	IN	_	28	case	_	_
27	24	24	CD	CD	_	28	nummod	_	_
28	h	h	NN	NN	_	25	nmod	_	_
29	after	after	IN	IN	_	31	case	_	_
30	PMA	pma	NN	NN	_	31	compound	_	_
31	stimulation	stimulation	NN	NN	_	17	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	r-hTBP-1	r-htbp-1	NN	NN	_	4	nsubj	_	_
2	also	also	RB	RB	_	4	advmod	_	_
3	partially	partially	RB	RB	_	4	advmod	_	_
4	reversed	reverse	VBD	VBD	_	0	root	_	_
5	inhibition	inhibition	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	U1	u1	NN	NN	_	9	compound	_	_
8	cellular	cellular	JJ	JJ	_	9	amod	_	_
9	proliferation	proliferation	NN	NN	_	5	nmod	_	_
10	caused	cause	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	PMA	pma	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	r-hTBP-1	r-htbp-1	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	rhu	rhu	JJ	JJ	_	7	amod	_	_
5	TNFR	tnfr	NN	NN	_	7	compound	_	_
6	:	:	:	:	_	7	punct	_	_
7	Fc	fc	NN	NN	_	2	conj	_	_
8	blocked	block	VBD	VBD	_	0	root	_	_
9	PMA	pma	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	20	case	_	_
12	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
13	factor	factor	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	NK	nk	NN	NN	_	18	compound	_	_
16	)	)	-RRB-	-RRB-	_	18	punct	_	_
17	-kappa	-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	10	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	U1	u1	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	association	association	NN	NN	_	8	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	decreases	decrease	NNS	NNS	_	25	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
30	replication	replication	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	soluble	soluble	JJ	JJ	_	6	amod	_	_
5	TNF	tnf	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
9	stimuli-induced	stimuli-induced	JJ	JJ	_	11	amod	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NK-kappa	nk-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	11	conj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	chronically	chronically	RB	RB	_	21	advmod	_	_
19	infected	infected	JJ	JJ	_	21	amod	_	_
20	U1	u1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	intracellular	intracellular	JJ	JJ	_	4	amod	_	_
4	Ca2+	ca2+	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	oxidant-induced	oxidant-induced	JJ	JJ	_	9	amod	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	Jurkat	jurkat	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	13	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	subclone	subclone	NN	NN	_	5	conj	_	_
9	Wurzburg	wurzburg	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	8	dep	_	_
11	oxidant	oxidant	NN	NN	_	12	compound	_	_
12	challenge	challenge	NN	NN	_	13	nsubj	_	_
13	elevated	elevate	VBD	VBD	_	0	root	_	_
14	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	13	dobj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	mobilizing	mobilize	VBG	VBG	_	13	advcl	_	_
17	Ca2+	ca2+	NN	NN	_	16	dobj	_	_
18	from	from	IN	IN	_	20	case	_	_
19	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
20	stores	store	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	this	this	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	rapid	rapid	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	transient	transient	JJ	JJ	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	in	in	IN	IN	_	14	case	_	_
13	Wurzburg	wurzburg	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	18	nmod	_	_
15	the	the	DT	DT	_	16	det	_	_
16	response	response	NN	NN	_	18	nsubj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	slow	slow	JJ	JJ	_	7	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	sustained	sustained	JJ	JJ	_	18	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	H2O2-induced	h2o2-induced	JJ	JJ	_	3	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	9	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	Wurzburg	wurzburg	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	influenced	influence	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	extracellular	extracellular	JJ	JJ	_	15	amod	_	_
15	EGTA	egta	NN	NN	_	12	nmod	_	_
16	but	but	CC	CC	_	9	cc	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	totally	totally	RB	RB	_	19	advmod	_	_
19	inhibited	inhibit	VBN	VBN	_	9	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	cells	cell	NNS	NNS	_	19	nmod	_	_
22	that	that	WDT	WDT	_	24	nsubjpass	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	loaded	load	VBN	VBN	_	21	acl:relcl	_	_
25	with	with	IN	IN	_	27	case	_	_
26	esterified	esterify	VBN	VBN	_	27	amod	_	_
27	EGTA	egta	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	14	nmod	_	_
4	that	that	WDT	WDT	_	7	nsubj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	sensitive	sensitive	JJ	JJ	_	3	acl:relcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	H2O2-induced	h2o2-induced	JJ	JJ	_	11	amod	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	H2O2	h2o2	NN	NN	_	14	nsubj	_	_
14	potentiated	potentiate	VBD	VBD	_	0	root	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	presence	presence	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	sustained	sustained	JJ	JJ	_	22	amod	_	_
22	high	high	JJ	JJ	_	23	amod	_	_
23	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	19	nmod	_	_
24	following	follow	VBG	VBG	_	26	case	_	_
25	thapsigargin	thapsigargin	NN	NN	_	26	compound	_	_
26	treatment	treatment	NN	NN	_	14	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	alpha-lipoate	alpha-lipoate	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	N-acetylcysteine	n-acetylcysteine	NN	NN	_	5	conj	_	_
8	appeared	appear	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	17	mark	_	_
10	be	be	VB	VB	_	17	cop	_	_
11	,	,	,	,	_	17	punct	_	_
12	at	at	IN	IN	_	15	advmod	_	_
13	least	least	JJS	JJS	_	12	mwe	_	_
14	in	in	IN	IN	_	15	case	_	_
15	part	part	NN	NN	_	17	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	due	due	JJ	JJ	_	8	xcomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	ability	ability	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	stabilize	stabilize	VB	VB	_	20	acl	_	_
23	elevation	elevation	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	23	nmod	_	_
26	following	follow	VBG	VBG	_	28	case	_	_
27	oxidant	oxidant	NN	NN	_	28	compound	_	_
28	challenge	challenge	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Results	result	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	1	nmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	a	a	DT	DT	_	10	det	_	_
8	sustained	sustained	JJ	JJ	_	9	amod	_	_
9	elevated	elevated	JJ	JJ	_	10	amod	_	_
10	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	14	nsubj	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	significant	significant	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	5	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	oxidant-induced	oxidant-induced	JJ	JJ	_	18	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	new	new	JJ	JJ	_	4	amod	_	_
3	variant	variant	JJ	JJ	_	4	amod	_	_
4	translocation	translocation	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	acute	acute	JJ	JJ	_	8	amod	_	_
7	promyelocytic	promyelocytic	JJ	JJ	_	8	amod	_	_
8	leukaemia	leukaemia	NN	NN	_	4	nmod	_	_
9	:	:	:	:	_	4	punct	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	characterization	characterization	NN	NN	_	4	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	clinical	clinical	JJ	JJ	_	14	amod	_	_
14	correlation	correlation	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Translocation	translocation	NN	NN	_	2	compound	_	_
2	t(15;17)(q22;q21)	t(15;17)(q22;q21)	NN	NN	_	8	nsubj	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	an	a	DT	DT	_	8	det	_	_
5	acquired	acquire	VBN	VBN	_	8	amod	_	_
6	clonal	clonal	JJ	JJ	_	5	dep	_	_
7	cytogenetic	cytogenetic	JJ	JJ	_	5	dep	_	_
8	change	change	NN	NN	_	0	root	_	_
9	present	present	JJ	JJ	_	8	amod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	almost	almost	RB	RB	_	12	advmod	_	_
12	all	all	DT	DT	_	13	amod	_	_
13	cases	case	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	promelocytic	promelocytic	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	APL	apl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	molecular	molecular	JJ	JJ	_	4	amod	_	_
3	genetic	genetic	JJ	JJ	_	4	amod	_	_
4	basis	basis	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	translocation	translocation	NN	NN	_	4	nmod	_	_
8	supports	support	VBZ	VBZ	_	0	root	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	integral	integral	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	pathogenesis	pathogenesis	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	patient	patient	NN	NN	_	2	dobj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	APL	apl	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	whom	whom	WP	WP	_	13	nmod	_	_
9	the	the	DT	DT	_	11	det	_	_
10	leukaemic	leukaemic	JJ	JJ	_	11	amod	_	_
11	clone	clone	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	characterized	characterize	VBN	VBN	_	4	acl:relcl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	true	true	JJ	JJ	_	17	amod	_	_
17	variant	variant	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	classical	classical	JJ	JJ	_	21	amod	_	_
21	t(15;17)	t(15;17)	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	patient	patient	NN	NN	_	11	nsubj	_	_
3	whose	whose	WP$	WP$	_	4	nmod:poss	_	_
4	disease	disease	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	2	acl:relcl	_	_
6	numerous	numerous	JJ	JJ	_	9	amod	_	_
7	atypical	atypical	JJ	JJ	_	6	dep	_	_
8	clinical	clinical	JJ	JJ	_	6	dep	_	_
9	features	feature	NNS	NNS	_	5	dobj	_	_
10	,	,	,	,	_	2	punct	_	_
11	had	have	VBD	VBD	_	0	root	_	_
12	t(11;17)(q13;121)	t(11;17)(q13;121)	NN	NN	_	11	dobj	_	_
13	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	chromosome	chromosome	NN	NN	_	4	compound	_	_
3	17	17	CD	CD	_	4	nummod	_	_
4	breakpoint	breakpoint	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	intron	intron	NN	NN	_	6	nmod	_	_
9	2	2	CD	CD	_	8	nummod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	RARA	rara	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	Southern	southern	NN	NN	_	14	compound	_	_
14	blotting	blotting	NN	NN	_	6	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	there	there	EX	EX	_	18	expl	_	_
18	was	be	VBD	VBD	_	6	conj	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	evidence	evidence	NN	NN	_	18	nsubj	_	_
21	at	at	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	molecular	molecular	JJ	JJ	_	24	amod	_	_
24	level	level	NN	NN	_	20	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	rearrangement	rearrangement	NN	NN	_	20	nmod	_	_
27	at	at	IN	IN	_	29	case	_	_
28	PML	pml	NN	NN	_	29	compound	_	_
29	locus	locus	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	15	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	along	along	IN	IN	_	7	case	_	_
5	with	with	IN	IN	_	7	case	_	_
6	previous	previous	JJ	JJ	_	7	amod	_	_
7	reports	report	NNS	NNS	_	15	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	rare	rare	JJ	JJ	_	11	amod	_	_
10	variant	variant	JJ	JJ	_	11	amod	_	_
11	translocations	translocation	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	APL	apl	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	15	punct	_	_
15	indicate	indicate	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	37	mark	_	_
17	while	while	IN	IN	_	26	mark	_	_
18	dysregulation	dysregulation	NN	NN	_	26	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	RARA	rara	NN	NN	_	18	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	fusion	fusion	NN	NN	_	18	nmod	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	cop	_	_
26	essential	essential	JJ	JJ	_	37	advcl	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	APL	apl	NN	NN	_	30	compound	_	_
30	phenotype	phenotype	NN	NN	_	26	nmod	_	_
31	,	,	,	,	_	37	punct	_	_
32	the	the	DT	DT	_	35	det	_	_
33	particular	particular	JJ	JJ	_	35	amod	_	_
34	fusion	fusion	NN	NN	_	35	compound	_	_
35	partner	partner	NN	NN	_	37	nsubj	_	_
36	may	may	MD	MD	_	37	aux	_	_
37	determine	determine	VB	VB	_	15	ccomp	_	_
38	clinicopathological	clinicopathological	JJ	JJ	_	39	amod	_	_
39	aspects	aspect	NNS	NNS	_	37	dobj	_	_
40	,	,	,	,	_	39	punct	_	_
41	including	include	VBG	VBG	_	42	case	_	_
42	presentation	presentation	NN	NN	_	39	nmod	_	_
43	,	,	,	,	_	42	punct	_	_
44	response	response	NN	NN	_	42	conj	_	_
45	to	to	TO	TO	_	46	case	_	_
46	treatment	treatment	NN	NN	_	44	nmod	_	_
47	with	with	IN	IN	_	50	case	_	_
48	all-trans	all-trans	JJ	JJ	_	50	amod	_	_
49	retinoic	retinoic	JJ	JJ	_	50	amod	_	_
50	acid	acid	NN	NN	_	46	nmod	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	ATRA	atra	NN	NN	_	50	appos	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	,	,	,	,	_	42	punct	_	_
55	and	and	CC	CC	_	42	cc	_	_
56	prognosis	prognosis	NN	NN	_	42	conj	_	_
57	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	heterogeneity	heterogeneity	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	variant	variant	JJ	JJ	_	8	amod	_	_
7	fusion	fusion	NN	NN	_	8	compound	_	_
8	partners	partner	NNS	NNS	_	13	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	RARA	rara	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	APL	apl	NN	NN	_	8	nmod	_	_
13	encode	encode	VBP	VBP	_	3	ccomp	_	_
14	factors	factor	NNS	NNS	_	13	dobj	_	_
15	with	with	IN	IN	_	16	case	_	_
16	properties	property	NNS	NNS	_	14	nmod	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	common	common	JJ	JJ	_	16	amod	_	_
19	to	to	TO	TO	_	18	nmod	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	distinct	distinct	JJ	JJ	_	18	conj	_	_
22	from	from	IN	IN	_	21	nmod	_	_
23	those	those	DT	DT	_	18	dep	_	_
24	of	of	IN	IN	_	25	case	_	_
25	PML	pml	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Investigation	investigation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	promises	promise	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	shed	shed	VB	VB	_	5	xcomp	_	_
8	light	light	NN	NN	_	7	dobj	_	_
9	on	on	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	complex	complex	JJ	JJ	_	13	amod	_	_
12	development	development	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	7	nmod	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	haematopoiesis	haematopoiesis	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	STAT-related	stat-related	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	activated	activate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	from	from	IN	IN	_	14	case	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	patients	patient	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	signal	signal	NN	NN	_	4	compound	_	_
3	transduction	transduction	NN	NN	_	4	compound	_	_
4	pathway	pathway	NN	NN	_	12	nsubjpass	_	_
5	activated	activate	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	many	many	JJ	JJ	_	8	amod	_	_
8	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
9	has	have	VBZ	VBZ	_	12	aux	_	_
10	recently	recently	RB	RB	_	12	advmod	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	elaborated	elaborate	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	JAK	jak	NN	NN	_	3	compound	_	_
3	kinases	kinase	NNS	NNS	_	18	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transducers	transducer	NNS	NNS	_	3	conj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	activators	activator	NNS	NNS	_	15	compound	_	_
10	of	of	IN	IN	_	15	amod	_	_
11	transcription	transcription	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	STAT	stat	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	factors	factor	NNS	NNS	_	7	conj	_	_
16	have	have	VBP	VBP	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	22	mark	_	_
20	be	be	VB	VB	_	22	cop	_	_
21	essential	essential	JJ	JJ	_	22	amod	_	_
22	components	component	NNS	NNS	_	18	xcomp	_	_
23	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	STAT	stat	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	8	nmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	acute	acute	JJ	JJ	_	22	amod	_	_
22	leukemia	leukemia	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	oligonucleotide	oligonucleotide	JJ	JJ	_	4	amod	_	_
4	probes	probe	NNS	NNS	_	2	dobj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	beta-casein	beta-casein	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IRF-1	irf-1	NN	NN	_	7	conj	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	promoters	promoter	NNS	NNS	_	7	dep	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	ISRE	isre	NN	NN	_	15	compound	_	_
15	probe	probe	NN	NN	_	4	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	detect	detect	VB	VB	_	2	advcl	_	_
18	STAT	stat	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	extracts	extract	NNS	NNS	_	17	nmod	_	_
23	from	from	IN	IN	_	26	case	_	_
24	acute	acute	JJ	JJ	_	26	amod	_	_
25	leukemia	leukemia	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	bandshift	bandshift	NN	NN	_	29	compound	_	_
29	assays	assay	NNS	NNS	_	17	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Specific	specific	JJ	JJ	_	5	amod	_	_
2	DNA	dna	NN	NN	_	5	compound	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	complex	complex	NN	NN	_	5	compound	_	_
5	formation	formation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	probes	probe	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	dep	_	_
13	beta-casein	beta-casein	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IRF-1	irf-1	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	promoters	promoter	NNS	NNS	_	13	conj	_	_
18	,	,	,	,	_	10	punct	_	_
19	but	but	CC	CC	_	10	cc	_	_
20	not	not	RB	RB	_	25	neg	_	_
21	with	with	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	ISRE	isre	NN	NN	_	25	compound	_	_
24	oligonucleotide	oligonucleotide	NN	NN	_	25	compound	_	_
25	probe	probe	NN	NN	_	10	conj	_	_
26	,	,	,	,	_	7	punct	_	_
27	when	when	WRB	WRB	_	45	advmod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	extracts	extract	NNS	NNS	_	45	nsubjpass	_	_
30	from	from	IN	IN	_	33	case	_	_
31	acute	acute	JJ	JJ	_	33	amod	_	_
32	lymphoblastic	lymphoblastic	JJ	JJ	_	33	amod	_	_
33	leukemia	leukemia	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	ALL	all	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	33	cc	_	_
38	acute	acute	JJ	JJ	_	40	amod	_	_
39	myeloid	myeloid	JJ	JJ	_	40	amod	_	_
40	leukemia	leukemia	NN	NN	_	33	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	AML	aml	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	were	be	VBD	VBD	_	45	auxpass	_	_
45	investigated	investigate	VBN	VBN	_	7	advcl	_	_
46	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	nonradioactive	nonradioactive	JJ	JJ	_	4	amod	_	_
4	oligonucleotides	oligonucleotide	NNS	NNS	_	2	dobj	_	_
5	as	as	IN	IN	_	6	case	_	_
6	competitors	competitor	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	show	show	VB	VB	_	2	advcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	specificity	specificity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	complex	complex	NN	NN	_	14	compound	_	_
14	formation	formation	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	antibodies	antibody	NNS	NNS	_	10	nsubjpass	_	_
3	directed	direct	VBN	VBN	_	2	acl	_	_
4	against	against	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	individual	individual	JJ	JJ	_	8	amod	_	_
7	STAT	stat	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	3	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	supershift	supershift	NN	NN	_	13	compound	_	_
13	experiments	experiment	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	STAT5-	stat5-	NN	NN	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	STAT1-related	stat1-related	JJ	JJ	_	1	conj	_	_
4	factors	factor	NNS	NNS	_	1	dep	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	ALL	all	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	STAT1-	stat1-	NN	NN	_	18	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	STAT3-	stat3-	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	STAT5-related	stat5-related	JJ	JJ	_	10	conj	_	_
16	proteins	protein	NNS	NNS	_	10	dep	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	present	present	JJ	JJ	_	6	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	extracts	extract	NNS	NNS	_	18	nmod	_	_
23	from	from	IN	IN	_	24	case	_	_
24	AML	aml	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	treated	treat	VBN	VBN	_	17	advcl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
9	before	before	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	extracted	extract	VBN	VBN	_	6	advcl	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	conclude	conclude	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	23	mark	_	_
19	these	these	DT	DT	_	20	det	_	_
20	factors	factor	NNS	NNS	_	23	nsubjpass	_	_
21	are	be	VBP	VBP	_	23	auxpass	_	_
22	constitutively	constitutively	RB	RB	_	23	advmod	_	_
23	activated	activate	VBN	VBN	_	17	ccomp	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vivo	vivo	FW	FW	_	23	advmod	_	_
26	.	.	.	.	_	17	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	likely	likely	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	STAT	stat	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	a	a	DT	DT	_	13	det	_	_
13	part	part	NN	NN	_	3	ccomp	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	events	event	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	leukemogenesis	leukemogenesis	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	p13MTCP1	p13mtcp1	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	restricted	restricted	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	5	dep	_	_
7	mature	mature	VB	VB	_	9	dep	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	proliferations	proliferation	NNS	NNS	_	6	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	t(X;14)	t(x;14)	NN	NN	_	12	compound	_	_
12	translocations	translocation	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	T-cell	t-cell	NN	NN	_	3	compound	_	_
2	prolymphocytic	prolymphocytic	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	35	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	T-PLL	t-pll	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	rare	rare	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	3	appos	_	_
11	of	of	IN	IN	_	14	case	_	_
12	mature	mature	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	leukemias	leukemia	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	ataxia	ataxia	NN	NN	_	20	compound	_	_
18	telangiectasia	telangiectasia	NN	NN	_	20	compound	_	_
19	clonal	clonal	JJ	JJ	_	20	amod	_	_
20	proliferation	proliferation	NN	NN	_	3	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	24	det	_	_
23	related	related	JJ	JJ	_	24	amod	_	_
24	condition	condition	NN	NN	_	20	appos	_	_
25	occurring	occurring	NN	NN	_	24	dep	_	_
26	in	in	IN	IN	_	27	case	_	_
27	patients	patient	NNS	NNS	_	25	nmod	_	_
28	suffering	suffer	VBG	VBG	_	27	acl	_	_
29	from	from	IN	IN	_	31	case	_	_
30	ataxia	ataxia	NN	NN	_	31	compound	_	_
31	telangiectasia	telangiectasia	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	3	punct	_	_
33	have	have	VBP	VBP	_	35	aux	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	associated	associate	VBN	VBN	_	0	root	_	_
36	to	to	TO	TO	_	37	case	_	_
37	translocations	translocation	NNS	NNS	_	35	nmod	_	_
38	involving	involve	VBG	VBG	_	37	acl	_	_
39	the	the	DT	DT	_	40	dep	_	_
40	14q32.1	14q32.1	NN	NN	_	38	dobj	_	_
41	or	or	CC	CC	_	40	cc	_	_
42	Xq28	xq28	NN	NN	_	43	compound	_	_
43	regions	region	NNS	NNS	_	40	conj	_	_
44	,	,	,	,	_	40	punct	_	_
45	where	where	WRB	WRB	_	47	advmod	_	_
46	are	be	VBP	VBP	_	47	cop	_	_
47	located	located	JJ	JJ	_	40	acl:relcl	_	_
48	the	the	DT	DT	_	53	det	_	_
49	TCL1	tcl1	NN	NN	_	53	compound	_	_
50	and	and	CC	CC	_	49	cc	_	_
51	MTCP1	mtcp1	NN	NN	_	49	conj	_	_
52	putative	putative	JJ	JJ	_	53	amod	_	_
53	oncogenes	oncogene	NNS	NNS	_	47	dep	_	_
54	,	,	,	,	_	47	punct	_	_
55	respectively	respectively	RB	RB	_	47	advmod	_	_
56	.	.	.	.	_	35	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	MTCP1	mtcp1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	involved	involve	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	t(X;14)(q28;q11)	t(x;14)(q28;q11)	NN	NN	_	9	compound	_	_
9	translocation	translocation	NN	NN	_	5	nmod	_	_
10	associated	associate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	these	these	DT	DT	_	14	det	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	proliferations	proliferation	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	3	nsubj	_	_
3	generates	generate	VBZ	VBZ	_	0	root	_	_
4	type	type	NN	NN	_	3	dobj	_	_
5	A	a	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	B	b	NN	NN	_	4	conj	_	_
8	transcripts	transcript	NNS	NNS	_	4	dep	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	potentially	potentially	RB	RB	_	11	advmod	_	_
11	encode	encode	VBP	VBP	_	4	acl:relcl	_	_
12	two	two	CD	CD	_	15	nummod	_	_
13	entirely	entirely	RB	RB	_	14	advmod	_	_
14	distinct	distinct	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	11	dobj	_	_
16	;	;	:	:	_	3	punct	_	_
17	type	type	NN	NN	_	20	nsubj	_	_
18	A	a	NN	NN	_	19	compound	_	_
19	transcripts	transcript	NNS	NNS	_	17	dep	_	_
20	code	code	VBP	VBP	_	3	parataxis	_	_
21	for	for	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	small	small	JJ	JJ	_	25	amod	_	_
24	mitochondrial	mitochondrial	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	p8MTCP1	p8mtcp1	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	20	punct	_	_
29	and	and	CC	CC	_	20	cc	_	_
30	type	type	NN	NN	_	32	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	transcripts	transcript	NNS	NNS	_	42	nsubj	_	_
33	,	,	,	,	_	32	punct	_	_
34	containing	contain	VBG	VBG	_	32	acl	_	_
35	an	a	DT	DT	_	39	det	_	_
36	additional	additional	JJ	JJ	_	39	amod	_	_
37	open	open	NN	NN	_	39	compound	_	_
38	reading	reading	NN	NN	_	39	compound	_	_
39	frame	frame	NN	NN	_	34	dobj	_	_
40	,	,	,	,	_	32	punct	_	_
41	may	may	MD	MD	_	42	aux	_	_
42	code	code	VBP	VBP	_	20	conj	_	_
43	for	for	IN	IN	_	46	case	_	_
44	107	107	CD	CD	_	46	nummod	_	_
45	amino-acid	amino-acid	JJ	JJ	_	46	amod	_	_
46	protein	protein	NN	NN	_	42	nmod	_	_
47	,	,	,	,	_	46	punct	_	_
48	p13MTCP1	p13mtcp1	NN	NN	_	46	appos	_	_
49	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	cloned	clone	VBN	VBN	_	5	amod	_	_
4	TCL1	tcl1	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	18	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	involved	involve	VBN	VBN	_	5	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	translocations	translocation	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	inversions	inversion	NNS	NNS	_	10	conj	_	_
13	associated	associate	VBN	VBN	_	10	acl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	proliferations	proliferation	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	codes	code	VBZ	VBZ	_	0	root	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	14-kD	14-kd	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	18	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	displays	display	VBZ	VBZ	_	22	acl:relcl	_	_
25	significant	significant	JJ	JJ	_	26	amod	_	_
26	homology	homology	NN	NN	_	24	dobj	_	_
27	with	with	IN	IN	_	28	case	_	_
28	p13MTCP1	p13mtcp1	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	rabbit	rabbit	NN	NN	_	5	compound	_	_
5	antisera	antisera	NNS	NNS	_	3	dobj	_	_
6	against	against	IN	IN	_	10	case	_	_
7	this	this	DT	DT	_	10	det	_	_
8	putative	putative	JJ	JJ	_	10	amod	_	_
9	p13MTCP1	p13mtcp1	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	3	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	screened	screen	VBN	VBN	_	3	conj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	expression	expression	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	p13MTCP1	p13mtcp1	NN	NN	_	19	compound	_	_
17	normal	normal	JJ	JJ	_	19	amod	_	_
18	lymphoid	lymphoid	JJ	JJ	_	19	amod	_	_
19	tissues	tissue	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	33	33	CD	CD	_	22	nummod	_	_
22	cases	case	NNS	NNS	_	14	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	immature	immature	JJ	JJ	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	mature	mature	JJ	JJ	_	24	conj	_	_
27	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	proliferations	proliferation	NNS	NNS	_	24	dep	_	_
30	using	use	VBG	VBG	_	12	xcomp	_	_
31	a	a	DT	DT	_	35	det	_	_
32	sensitive	sensitive	JJ	JJ	_	35	amod	_	_
33	Western	western	NN	NN	_	35	compound	_	_
34	blot	blot	NN	NN	_	35	compound	_	_
35	assay	assay	NN	NN	_	30	dobj	_	_
36	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	MTCP1	mtcp1	NN	NN	_	6	compound	_	_
6	locus	locus	NN	NN	_	7	compound	_	_
7	configuration	configuration	NN	NN	_	3	dobj	_	_
8	by	by	IN	IN	_	11	case	_	_
9	Southern	southern	NN	NN	_	11	compound	_	_
10	blot	blot	NN	NN	_	11	compound	_	_
11	analysis	analysis	NN	NN	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	p13MTCP1	p13mtcp1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	three	three	CD	CD	_	10	nummod	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	proliferations	proliferation	NNS	NNS	_	5	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	MTCP1	mtcp1	NN	NN	_	13	compound	_	_
13	rearrangements	rearrangement	NNS	NNS	_	10	nmod	_	_
14	because	because	IN	IN	_	17	case	_	_
15	of	of	IN	IN	_	17	case	_	_
16	t(X;14)	t(x;14)	NN	NN	_	17	compound	_	_
17	translocations	translocation	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	but	but	CC	CC	_	5	cc	_	_
20	neither	neither	CC	CC	_	23	cc:preconj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	normal	normal	JJ	JJ	_	23	amod	_	_
23	resting	rest	VBG	VBG	_	5	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	activated	activate	VBN	VBN	_	26	amod	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	23	conj	_	_
27	nor	nor	CC	CC	_	23	cc	_	_
28	in	in	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	other	other	JJ	JJ	_	32	amod	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	leukemias	leukemia	NNS	NNS	_	23	conj	_	_
33	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	p13MTCP1	p13mtcp1	NN	NN	_	10	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	p14TCL1	p14tcl1	NN	NN	_	7	conj	_	_
10	form	form	VBP	VBP	_	5	ccomp	_	_
11	a	a	DT	DT	_	14	det	_	_
12	new	new	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	10	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	plays	play	VBZ	VBZ	_	14	acl:relcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	key	key	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	pathogenesis	pathogenesis	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	T-PLL	t-pll	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	related	related	JJ	JJ	_	27	amod	_	_
27	conditions	condition	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	C-terminal	c-terminal	JJ	JJ	_	2	amod	_	_
2	activating	activate	VBG	VBG	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	inhibitory	inhibitory	JJ	JJ	_	2	conj	_	_
5	domains	domain	NNS	NNS	_	2	dep	_	_
6	determine	determine	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transactivation	transactivation	NN	NN	_	9	compound	_	_
9	potential	potential	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	BSAP	bsap	NN	NN	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Pax-5	pax-5	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	Pax-2	pax-2	NN	NN	_	11	conj	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	Pax-8	pax-8	NN	NN	_	11	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	Pax-5	pax-5	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	2	dobj	_	_
6	BSAP	bsap	NN	NN	_	5	dep	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	plays	play	VBZ	VBZ	_	5	acl:relcl	_	_
9	an	a	DT	DT	_	11	det	_	_
10	essential	essential	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	early	early	JJ	JJ	_	16	amod	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	development	development	NN	NN	_	8	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	midbrain	midbrain	JJ	JJ	_	19	amod	_	_
19	patterning	patterning	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	analysed	analyse	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	structural	structural	JJ	JJ	_	9	amod	_	_
9	requirements	requirement	NNS	NNS	_	6	dobj	_	_
10	for	for	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	BSAP	bsap	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	mutagenesis	mutagenesis	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	transient	transient	JJ	JJ	_	6	amod	_	_
6	transfection	transfection	NN	NN	_	3	conj	_	_
7	experiments	experiment	NNS	NNS	_	3	dep	_	_
8	indicate	indicate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	the	the	DT	DT	_	13	det	_	_
11	C-terminal	c-terminal	JJ	JJ	_	13	amod	_	_
12	serine/threonine/proline-rich	serine/threonine/proline-rich	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	16	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	BSAP	bsap	NN	NN	_	13	nmod	_	_
16	contains	contain	VBZ	VBZ	_	8	ccomp	_	_
17	a	a	DT	DT	_	20	det	_	_
18	potent	potent	JJ	JJ	_	20	amod	_	_
19	transactivation	transactivation	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	55	55	CD	CD	_	24	nummod	_	_
23	amino	amino	NN	NN	_	24	compound	_	_
24	acids	acid	NNS	NNS	_	20	nmod	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	active	active	JJ	JJ	_	20	acl:relcl	_	_
28	from	from	IN	IN	_	29	case	_	_
29	promoter	promoter	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	enhancer	enhancer	NN	NN	_	29	conj	_	_
32	positions	position	NNS	NNS	_	29	dep	_	_
33	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	transactivation	transactivation	NN	NN	_	3	compound	_	_
3	domain	domain	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	inactivated	inactivate	VBN	VBN	_	5	xcomp	_	_
9	by	by	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	naturally	naturally	RB	RB	_	12	advmod	_	_
12	occurring	occur	VBG	VBG	_	14	amod	_	_
13	frameshift	frameshift	NN	NN	_	14	compound	_	_
14	mutation	mutation	NN	NN	_	8	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	one	one	CD	CD	_	18	nummod	_	_
17	PAX-5	pax-5	NN	NN	_	18	compound	_	_
18	allele	allele	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	26	case	_	_
20	the	the	DT	DT	_	26	det	_	_
21	acute	acute	JJ	JJ	_	26	amod	_	_
22	lymphoblastic	lymphoblastic	JJ	JJ	_	26	amod	_	_
23	leukemia	leukemia	NN	NN	_	26	compound	_	_
24	cell	cell	NN	NN	_	26	compound	_	_
25	line	line	NN	NN	_	26	compound	_	_
26	REH	reh	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transactivation	transactivation	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	negatively	negatively	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	adjacent	adjacent	JJ	JJ	_	12	amod	_	_
12	sequences	sequence	NNS	NNS	_	9	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	extreme	extreme	JJ	JJ	_	16	amod	_	_
16	C-terminus	c-terminus	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	activating	activate	VBG	VBG	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	inhibitory	inhibitory	JJ	JJ	_	2	conj	_	_
5	domains	domain	NNS	NNS	_	2	dep	_	_
6	function	function	VBP	VBP	_	0	root	_	_
7	together	together	RB	RB	_	6	advmod	_	_
8	as	as	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	independent	independent	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	module	module	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	different	different	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	types	type	NNS	NNS	_	12	nmod	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	shown	show	VBN	VBN	_	6	advcl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	fusion	fusion	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	GAL4	gal4	NN	NN	_	26	compound	_	_
24	DNA	dna	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	domain	domain	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	same	same	JJ	JJ	_	3	amod	_	_
3	arrangement	arrangement	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	positively	positively	RB	RB	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	negatively	negatively	RB	RB	_	5	conj	_	_
8	acting	act	VBG	VBG	_	9	amod	_	_
9	sequences	sequence	NNS	NNS	_	5	dep	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	conserved	conserve	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	mammalian	mammalian	JJ	JJ	_	16	amod	_	_
16	Pax-2	pax-2	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Pax-8	pax-8	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	zebrafish	zebrafish	NN	NN	_	22	compound	_	_
22	Pax-b	pax-b	NN	NN	_	16	conj	_	_
23	as	as	RB	RB	_	16	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	the	the	DT	DT	_	30	det	_	_
27	sea	sea	NN	NN	_	30	compound	_	_
28	urchin	urchin	NN	NN	_	30	compound	_	_
29	Pax-258	pax-258	NN	NN	_	30	compound	_	_
30	proteins	protein	NNS	NNS	_	16	conj	_	_
31	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	competence	competence	NN	NN	_	15	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	subfamily	subfamily	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Pax	pax	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	determined	determine	VBN	VBN	_	3	ccomp	_	_
16	by	by	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	C-terminal	c-terminal	JJ	JJ	_	20	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	module	module	NN	NN	_	15	nmod	_	_
21	composed	compose	VBN	VBN	_	20	acl	_	_
22	of	of	IN	IN	_	23	case	_	_
23	activating	activate	VBG	VBG	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inhibitory	inhibitory	JJ	JJ	_	23	conj	_	_
26	sequences	sequence	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor	factor	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	activated	activate	VBN	VBN	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	nmod:npmod	_	_
12	A-resistant	a-resistant	JJ	JJ	_	13	amod	_	_
13	pathway	pathway	NN	NN	_	1	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	action	action	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	immunosuppressive	immunosuppressive	JJ	JJ	_	8	amod	_	_
8	drug	drug	NN	NN	_	4	nmod	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	8	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CsA	csa	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	the	the	DT	DT	_	16	det	_	_
16	inactivation	inactivation	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	Ca2+/calmodulin-dependent	ca2+/calmodulin-dependent	JJ	JJ	_	22	amod	_	_
20	serine-threonine	serine-threonine	NN	NN	_	22	compound	_	_
21	phosphatase	phosphatase	NN	NN	_	22	compound	_	_
22	calcineurin	calcineurin	NN	NN	_	16	nmod	_	_
23	by	by	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	drug-immunophilin	drug-immunophilin	JJ	JJ	_	26	amod	_	_
26	complex	complex	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Inactive	inactive	JJ	JJ	_	2	amod	_	_
2	calcineurin	calcineurin	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	unable	unable	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	activate	activate	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NFAT	nfat	NN	NN	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	9	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	9	appos	_	_
21	required	require	VBN	VBN	_	20	acl	_	_
22	for	for	IN	IN	_	23	case	_	_
23	expression	expression	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	31	case	_	_
25	the	the	DT	DT	_	31	det	_	_
26	interleukin	interleukin	NN	NN	_	31	compound	_	_
27	2	2	CD	CD	_	26	nummod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	IL-2	il-2	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	gene	gene	NN	NN	_	23	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	9	nsubjpass	_	_
3	by	by	IN	IN	_	5	case	_	_
4	CsA-treated	csa-treated	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	9	auxpass	_	_
7	therefore	therefore	RB	RB	_	9	advmod	_	_
8	dramatically	dramatically	RB	RB	_	9	advmod	_	_
9	reduced	reduce	VBN	VBN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	,	,	,	,	_	2	punct	_	_
5	however	however	RB	RB	_	2	advmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	NFAT	nfat	NN	NN	_	11	nsubjpass	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	activated	activate	VBN	VBN	_	2	ccomp	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IL-2	il-2	NN	NN	_	15	nmod	_	_
18	can	can	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	produced	produce	VBN	VBN	_	11	conj	_	_
21	by	by	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	CsA-resistant	csa-resistant	JJ	JJ	_	25	amod	_	_
24	CD28-signaling	cd28-signaling	JJ	JJ	_	25	amod	_	_
25	pathway	pathway	NN	NN	_	11	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	multicopy	multicopy	JJ	JJ	_	8	amod	_	_
8	NFAT-	nfat-	NN	NN	_	17	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-2	il-2	NN	NN	_	13	compound	_	_
11	promoter-beta-galactosidase	promoter-beta-galactosidase	NN	NN	_	13	compound	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	conj	_	_
14	constructs	construct	NNS	NNS	_	8	dep	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	activated	activate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	26	case	_	_
19	phorbol	phorbol	NN	NN	_	26	compound	_	_
20	12-myristate	12-myristate	NN	NN	_	26	compound	_	_
21	13-acetate	13-acetate	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	PMA	pma	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	/alpha-CD28	/alpha-cd28	NN	NN	_	26	compound	_	_
26	stimulation	stimulation	NN	NN	_	17	nmod	_	_
27	,	,	,	,	_	17	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	this	this	DT	DT	_	30	det	_	_
30	activation	activation	NN	NN	_	32	nsubj	_	_
31	was	be	VBD	VBD	_	32	cop	_	_
32	resistant	resistant	JJ	JJ	_	17	conj	_	_
33	to	to	TO	TO	_	34	case	_	_
34	CsA	csa	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	17	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	CsA-resistant	csa-resistant	JJ	JJ	_	12	amod	_	_
11	NFAT	nfat	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	extracts	extract	NNS	NNS	_	7	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
19	blood	blood	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	stimulated	stimulate	VBN	VBN	_	21	acl	_	_
23	with	with	IN	IN	_	24	case	_	_
24	PMA	pma	NN	NN	_	22	nmod	_	_
25	plus	plus	CC	CC	_	24	cc	_	_
26	alphaCD28	alphacd28	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	5	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	8	nsubj	_	_
5	stimulated	stimulate	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	PMA/alphaCD28	pma/alphacd28	NN	NN	_	5	nmod	_	_
8	produced	produce	VBD	VBD	_	0	root	_	_
9	IL-2	il-2	NN	NN	_	8	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	dep	_	_
12	presence	presence	NN	NN	_	14	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CsA	csa	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Collectively	collectively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	NFAT	nfat	NN	NN	_	10	nsubjpass	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	activated	activate	VBN	VBN	_	5	ccomp	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-2	il-2	NN	NN	_	15	nsubjpass	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	produced	produce	VBN	VBN	_	10	conj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	calcineurin	calcineurin	NN	NN	_	19	nmod:npmod	_	_
19	independent	independent	JJ	JJ	_	20	amod	_	_
20	manner	manner	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Structural	structural	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	functional	functional	JJ	JJ	_	1	conj	_	_
4	characterization	characterization	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	CD36	cd36	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	identification	identification	NN	NN	_	1	dep	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	proximal	proximal	JJ	JJ	_	17	amod	_	_
16	PEBP2/CBF	pebp2/cbf	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	CD36	cd36	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	surface	surface	NN	NN	_	0	root	_	_
6	glycoprotein	glycoprotein	NN	NN	_	5	dep	_	_
7	composed	compose	VBN	VBN	_	5	acl	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	single	single	JJ	JJ	_	12	amod	_	_
11	polypeptide	polypeptide	NN	NN	_	12	compound	_	_
12	chain	chain	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	interacts	interact	VBZ	VBZ	_	5	dep	_	_
16	with	with	IN	IN	_	17	case	_	_
17	thrombospondin	thrombospondin	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	collagens	collagen	NNS	NNS	_	20	compound	_	_
20	type	type	NN	NN	_	17	conj	_	_
21	I	i	CD	CD	_	20	dep	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	IV	iv	CD	CD	_	20	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	oxidized	oxidize	VBN	VBN	_	28	amod	_	_
26	low	low	JJ	JJ	_	28	amod	_	_
27	density	density	NN	NN	_	28	compound	_	_
28	lipoprotein	lipoprotein	NN	NN	_	17	conj	_	_
29	,	,	,	,	_	17	punct	_	_
30	fatty	fatty	JJ	JJ	_	31	amod	_	_
31	acids	acid	NNS	NNS	_	17	conj	_	_
32	,	,	,	,	_	17	punct	_	_
33	anionic	anionic	JJ	JJ	_	34	amod	_	_
34	phospholipids	phospholipid	NNS	NNS	_	17	conj	_	_
35	,	,	,	,	_	17	punct	_	_
36	and	and	CC	CC	_	17	cc	_	_
37	erythrocytes	erythrocyte	NNS	NNS	_	17	conj	_	_
38	parasitized	parasitize	VBN	VBN	_	37	acl	_	_
39	with	with	IN	IN	_	41	case	_	_
40	Plasmodium	plasmodium	NN	NN	_	41	compound	_	_
41	falciparum	falciparum	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	5	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	expression	expression	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	restricted	restricted	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	few	few	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	types	type	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	12	case	_	_
12	monocyte/macrophages	monocyte/macrophages	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	CD36	cd36	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	phagocytosis	phagocytosis	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	apoptotic	apoptotic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	foam	foam	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	9	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	uptake	uptake	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	oxidized	oxidize	VBN	VBN	_	24	amod	_	_
22	low	low	JJ	JJ	_	24	amod	_	_
23	density	density	NN	NN	_	24	compound	_	_
24	lipoprotein	lipoprotein	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	control	control	VBP	VBP	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD36	cd36	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	we	we	PRP	PRP	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	isolated	isolate	VBN	VBN	_	2	parataxis	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	analyzed	analyze	VBN	VBN	_	19	conj	_	_
22	the	the	DT	DT	_	24	det	_	_
23	CD36	cd36	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	19	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	5'-deletion	5'-deletion	JJ	JJ	_	6	amod	_	_
6	fragments	fragment	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD36	cd36	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	coupled	couple	VBN	VBN	_	6	acl	_	_
12	to	to	TO	TO	_	13	case	_	_
13	luciferase	luciferase	NN	NN	_	11	nmod	_	_
14	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	29	mark	_	_
16	as	as	RB	RB	_	17	advmod	_	_
17	few	few	JJ	JJ	_	21	nummod	_	_
18	as	as	IN	IN	_	17	advmod	_	_
19	158	158	CD	CD	_	21	nummod	_	_
20	base	base	NN	NN	_	21	compound	_	_
21	pairs	pair	NNS	NNS	_	29	nsubj	_	_
22	upstream	upstream	JJ	JJ	_	21	amod	_	_
23	from	from	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	transcription	transcription	NN	NN	_	27	compound	_	_
26	initiation	initiation	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	21	nmod	_	_
28	were	be	VBD	VBD	_	29	cop	_	_
29	sufficient	sufficient	JJ	JJ	_	14	ccomp	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	direct	direct	VB	VB	_	29	xcomp	_	_
32	the	the	DT	DT	_	34	det	_	_
33	monocyte-specific	monocyte-specific	JJ	JJ	_	34	amod	_	_
34	transcription	transcription	NN	NN	_	31	dobj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	reporter	reporter	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	Within	within	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	above	above	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	fragment	fragment	NN	NN	_	8	compound	_	_
8	spanning	spanning	NN	NN	_	14	nsubjpass	_	_
9	nucleotides	nucleotide	NNS	NNS	_	8	dep	_	_
10	-158	-158	CD	CD	_	9	nummod	_	_
11	to	to	TO	TO	_	9	dep	_	_
12	-90	-90	CD	CD	_	9	nummod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	0	root	_	_
15	for	for	IN	IN	_	17	case	_	_
16	optimal	optimal	JJ	JJ	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	Biochemical	biochemical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	region	region	NN	NN	_	2	nmod	_	_
6	-158/-90	-158/-90	CD	CD	_	5	dep	_	_
7	revealed	reveal	VBN	VBN	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	site	site	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	24	case	_	_
15	the	the	DT	DT	_	24	det	_	_
16	polyomavirus	polyomavirus	NN	NN	_	24	compound	_	_
17	enhancer-binding	enhancer-binding	JJ	JJ	_	24	amod	_	_
18	protein	protein	NN	NN	_	24	compound	_	_
19	2/core-binding	2/core-binding	JJ	JJ	_	24	amod	_	_
20	factor	factor	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	PEBP2/CBF	pebp2/cbf	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	family	family	NN	NN	_	13	nmod	_	_
25	at	at	IN	IN	_	26	case	_	_
26	position	position	NN	NN	_	10	nmod	_	_
27	-103	-103	CD	CD	_	26	nummod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Disruption	disruption	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PEBP2/CBF	pebp2/cbf	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	markedly	markedly	RB	RB	_	7	advmod	_	_
7	diminished	diminish	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	PEBP2/CBF	pebp2/cbf	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD36	cd36	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	39	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	members	member	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	PEBP2/CBF	pebp2/cbf	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	chromosome	chromosome	NN	NN	_	11	compound	_	_
11	translocations	translocation	NNS	NNS	_	2	nmod	_	_
12	associated	associate	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	leukemia	leukemia	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	regulation	regulation	NN	NN	_	11	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	myeloid-specific	myeloid-specific	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	encoding	encode	VBG	VBG	_	26	acl	_	_
28	for	for	IN	IN	_	29	case	_	_
29	myeloperoxidase	myeloperoxidase	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	elastase	elastase	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	the	the	DT	DT	_	37	det	_	_
35	colony-stimulating	colony-stimulating	JJ	JJ	_	37	amod	_	_
36	factor	factor	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	29	conj	_	_
38	,	,	,	,	_	2	punct	_	_
39	highlights	highlight	VBZ	VBZ	_	0	root	_	_
40	the	the	DT	DT	_	41	det	_	_
41	relevance	relevance	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	regulation	regulation	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	49	case	_	_
46	the	the	DT	DT	_	49	det	_	_
47	CD36	cd36	NN	NN	_	49	compound	_	_
48	gene	gene	NN	NN	_	49	compound	_	_
49	promoter	promoter	NN	NN	_	44	nmod	_	_
50	in	in	IN	IN	_	52	case	_	_
51	monocytic	monocytic	JJ	JJ	_	52	amod	_	_
52	cells	cell	NNS	NNS	_	49	nmod	_	_
53	by	by	IN	IN	_	54	case	_	_
54	members	member	NNS	NNS	_	44	nmod	_	_
55	of	of	IN	IN	_	58	case	_	_
56	the	the	DT	DT	_	58	det	_	_
57	PEBP2/CBF	pebp2/cbf	NN	NN	_	58	compound	_	_
58	family	family	NN	NN	_	54	nmod	_	_
59	.	.	.	.	_	39	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T	t	NN	NN	_	5	compound	_	_
3	lymphotropic	lymphotropic	JJ	JJ	_	5	amod	_	_
4	virus-I	virus-i	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	expression	expression	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	beta-galactoside-binding	beta-galactoside-binding	JJ	JJ	_	15	amod	_	_
15	lectin	lectin	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	galectin-3	galectin-3	NN	NN	_	15	appos	_	_
18	.	.	.	.	_	10	punct	_	_

1	Animal	animal	NN	NN	_	3	nsubj	_	_
2	lectins	lectin	NNS	NNS	_	1	dep	_	_
3	play	play	VBP	VBP	_	0	root	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	roles	role	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	variety	variety	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	biological	biological	JJ	JJ	_	11	amod	_	_
11	processes	process	NNS	NNS	_	8	nmod	_	_
12	via	via	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	recognition	recognition	NN	NN	_	3	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	glycoconjugates	glycoconjugate	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Galectin-3	galectin-3	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	beta-galactoside-binding	beta-galactoside-binding	JJ	JJ	_	5	amod	_	_
5	lectin	lectin	NN	NN	_	0	root	_	_
6	previously	previously	RB	RB	_	5	advmod	_	_
7	designated	designate	VBN	VBN	_	5	acl	_	_
8	as	as	IN	IN	_	10	case	_	_
9	epsilon	epsilon	NN	NN	_	10	compound	_	_
10	BP	bp	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	IgE-binding	ige-binding	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	10	punct	_	_
16	CBP35	cbp35	NN	NN	_	10	conj	_	_
17	,	,	,	,	_	10	punct	_	_
18	Mac-2	mac-2	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	L-29	l-29	NN	NN	_	10	conj	_	_
21	,	,	,	,	_	10	punct	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	L-34	l-34	NN	NN	_	10	conj	_	_
24	,	,	,	,	_	5	punct	_	_
25	and	and	CC	CC	_	5	cc	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	expression	expression	NN	NN	_	30	nsubjpass	_	_
28	has	have	VBZ	VBZ	_	30	aux	_	_
29	been	be	VBN	VBN	_	30	auxpass	_	_
30	associated	associate	VBN	VBN	_	5	conj	_	_
31	with	with	IN	IN	_	33	case	_	_
32	various	various	JJ	JJ	_	33	amod	_	_
33	physiological	physiological	JJ	JJ	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	pathological	pathological	JJ	JJ	_	33	conj	_	_
36	processes	process	NNS	NNS	_	33	dep	_	_
37	,	,	,	,	_	33	punct	_	_
38	including	include	VBG	VBG	_	40	case	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	growth	growth	NN	NN	_	33	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	tumor	tumor	NN	NN	_	43	compound	_	_
43	transformation	transformation	NN	NN	_	40	conj	_	_
44	,	,	,	,	_	40	punct	_	_
45	and	and	CC	CC	_	40	cc	_	_
46	metastasis	metastasis	NN	NN	_	40	conj	_	_
47	.	.	.	.	_	5	punct	_	_

1	Galectin-3	galectin-3	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	widely	widely	RB	RB	_	4	advmod	_	_
4	distributed	distribute	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	various	various	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	types	type	NNS	NNS	_	7	conj	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	4	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	leukocytes	leukocyte	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	notable	notable	JJ	JJ	_	21	amod	_	_
21	exception	exception	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	B	b	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	T	t	NN	NN	_	23	conj	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	23	dep	_	_
27	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	galectin-3	galectin-3	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	abundantly	abundantly	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	24	case	_	_
13	human	human	JJ	JJ	_	24	amod	_	_
14	T	t	NN	NN	_	24	compound	_	_
15	lymphotropic	lymphotropic	JJ	JJ	_	24	amod	_	_
16	virus	virus	NN	NN	_	24	compound	_	_
17	(	(	-LRB-	-LRB-	_	24	punct	_	_
18	HTLV	htlv	NN	NN	_	24	compound	_	_
19	)	)	-RRB-	-RRB-	_	24	punct	_	_
20	-I-infected	-i-infected	JJ	JJ	_	24	amod	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	11	nmod	_	_
25	,	,	,	,	_	11	punct	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	F6T	f6t	NN	NN	_	11	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	HUT	hut	NN	NN	_	27	conj	_	_
30	102	102	CD	CD	_	29	nummod	_	_
31	,	,	,	,	_	27	punct	_	_
32	K3T	k3t	NN	NN	_	27	conj	_	_
33	,	,	,	,	_	27	punct	_	_
34	MT-2	mt-2	NN	NN	_	27	conj	_	_
35	,	,	,	,	_	27	punct	_	_
36	and	and	CC	CC	_	27	cc	_	_
37	SLB-I	slb-i	NN	NN	_	27	conj	_	_
38	,	,	,	,	_	8	punct	_	_
39	but	but	CC	CC	_	8	cc	_	_
40	is	be	VBZ	VBZ	_	42	auxpass	_	_
41	not	not	RB	RB	_	42	neg	_	_
42	expressed	express	VBN	VBN	_	8	conj	_	_
43	in	in	IN	IN	_	47	case	_	_
44	non-HTLV-I-infected	non-htlv-i-infected	JJ	JJ	_	47	amod	_	_
45	T	t	NN	NN	_	47	compound	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	lines	line	NNS	NNS	_	42	nmod	_	_
48	such	such	JJ	JJ	_	50	case	_	_
49	as	as	IN	IN	_	48	mwe	_	_
50	Jurkat	jurkat	NN	NN	_	47	nmod	_	_
51	,	,	,	,	_	50	punct	_	_
52	CEM	cem	NN	NN	_	50	conj	_	_
53	,	,	,	,	_	50	punct	_	_
54	and	and	CC	CC	_	50	cc	_	_
55	MOLT-4	molt-4	NN	NN	_	50	conj	_	_
56	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	galectin-3	galectin-3	NN	NN	_	6	compound	_	_
6	level	level	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	markedly	markedly	RB	RB	_	9	advmod	_	_
9	increased	increase	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	9	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	infection	infection	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	HTLV-I	htlv-i	NN	NN	_	14	nmod	_	_
17	as	as	IN	IN	_	18	mark	_	_
18	compared	compare	VBN	VBN	_	9	advcl	_	_
19	with	with	IN	IN	_	21	case	_	_
20	uninfected	uninfected	JJ	JJ	_	21	amod	_	_
21	thymocytes	thymocyte	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	up-regulation	up-regulation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	galectin-3	galectin-3	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	appeared	appear	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	correlate	correlate	VB	VB	_	6	xcomp	_	_
9	well	well	RB	RB	_	8	advmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	HTLV-I	htlv-i	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	as	as	IN	IN	_	24	mark	_	_
16	undetectable	undetectable	JJ	JJ	_	24	nsubjpass	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	very	very	RB	RB	_	19	advmod	_	_
19	low	low	JJ	JJ	_	16	conj	_	_
20	levels	level	NNS	NNS	_	16	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	galectin-3	galectin-3	NN	NN	_	16	nmod	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	found	find	VBN	VBN	_	6	advcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	S1T	s1t	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	ATL-1K	atl-1k	NN	NN	_	27	conj	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	lines	line	NNS	NNS	_	27	dep	_	_
32	,	,	,	,	_	27	punct	_	_
33	which	which	WDT	WDT	_	36	nsubjpass	_	_
34	are	be	VBP	VBP	_	36	auxpass	_	_
35	nonproductively	nonproductively	RB	RB	_	36	advmod	_	_
36	infected	infect	VBN	VBN	_	27	acl:relcl	_	_
37	with	with	IN	IN	_	38	case	_	_
38	HTLV-I	htlv-i	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	co-transfection	co-transfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	galectin-3	galectin-3	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	expression	expression	NN	NN	_	13	compound	_	_
13	vectors	vector	NNS	NNS	_	10	nmod	_	_
14	encoding	encode	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	40-kd	40-kd	JJ	JJ	_	18	amod	_	_
17	Tax	tax	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	14	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	22	det	_	_
21	potent	potent	JJ	JJ	_	22	amod	_	_
22	transactivator	transactivator	NN	NN	_	18	appos	_	_
23	in	in	IN	IN	_	24	case	_	_
24	HTLV-I	htlv-i	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Analysis	analysis	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	various	various	JJ	JJ	_	5	amod	_	_
4	Tax	tax	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	1	nmod	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	galectin-3	galectin-3	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	induction	induction	NN	NN	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	dependent	dependent	JJ	JJ	_	6	ccomp	_	_
13	on	on	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	23	case	_	_
16	the	the	DT	DT	_	23	det	_	_
17	cyclic-AMP-responsive	cyclic-amp-responsive	JJ	JJ	_	23	amod	_	_
18	element	element	NN	NN	_	23	compound	_	_
19	binding	binding	NN	NN	_	23	compound	_	_
20	protein/activation	protein/activation	NN	NN	_	23	compound	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	family	family	NN	NN	_	14	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	14	cc	_	_
28	,	,	,	,	_	14	punct	_	_
29	to	to	TO	TO	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	lesser	lesser	JJR	JJR	_	32	amod	_	_
32	extent	extent	NN	NN	_	14	conj	_	_
33	,	,	,	,	_	14	punct	_	_
34	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
35	factor-kappa	factor-kappa	NN	NN	_	36	compound	_	_
36	B/Rel	b/rel	NN	NN	_	37	compound	_	_
37	induction	induction	NN	NN	_	14	conj	_	_
38	.	.	.	.	_	6	punct	_	_

1	Transfection	transfection	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	promonocytic	promonocytic	JJ	JJ	_	6	amod	_	_
5	U-937	u-937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	12	case	_	_
8	an	a	DT	DT	_	12	det	_	_
9	HTLV-I	htlv-i	NN	NN	_	12	compound	_	_
10	Tax	tax	NN	NN	_	12	compound	_	_
11	expression	expression	NN	NN	_	12	compound	_	_
12	vector	vector	NN	NN	_	1	nmod	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	galectin-3	galectin-3	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	this	this	DT	DT	_	19	det	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Functionally	functionally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	galectin-3	galectin-3	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VBP	VBP	_	5	xcomp	_	_
8	interleukin-2	interleukin-2	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Jurkat	jurkat	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	raise	raise	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	possibility	possibility	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	HTLV-I	htlv-i	NN	NN	_	11	compound	_	_
10	Tax	tax	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	12	nsubj	_	_
12	induces	induce	VBZ	VBZ	_	7	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	subsequent	subsequent	JJ	JJ	_	17	amod	_	_
17	synthesis	synthesis	NN	NN	_	14	conj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	secretion	secretion	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	galectin-3	galectin-3	NN	NN	_	14	nmod	_	_
22	,	,	,	,	_	14	punct	_	_
23	which	which	WDT	WDT	_	28	nsubj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	turn	turn	NN	NN	_	28	nmod	_	_
26	may	may	MD	MD	_	28	aux	_	_
27	further	further	RB	RB	_	28	advmod	_	_
28	activate	activate	VB	VB	_	14	acl:relcl	_	_
29	these	these	DT	DT	_	31	det	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	dobj	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	contribute	contribute	VB	VB	_	28	conj	_	_
34	to	to	TO	TO	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	altered	altered	JJ	JJ	_	37	amod	_	_
37	properties	property	NNS	NNS	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	growth	growth	NN	NN	_	37	nmod	_	_
41	found	find	VBN	VBN	_	40	acl	_	_
42	in	in	IN	IN	_	46	case	_	_
43	adult	adult	JJ	JJ	_	46	amod	_	_
44	T	t	NN	NN	_	46	compound	_	_
45	cell	cell	NN	NN	_	46	compound	_	_
46	leukemia	leukemia	NN	NN	_	41	nmod	_	_
47	induced	induce	VBN	VBN	_	46	acl	_	_
48	by	by	IN	IN	_	49	case	_	_
49	HTLV-I	htlv-i	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	5	punct	_	_

1	Age-related	age-related	JJ	JJ	_	2	amod	_	_
2	decreases	decrease	NNS	NNS	_	11	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	impaired	impaired	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	factors	factor	NNS	NNS	_	14	nmod	_	_
19	AP-1	ap-1	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-AT	nf-at	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	16	mark	_	_
2	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
3	factors	factor	NNS	NNS	_	4	compound	_	_
4	AP-1	ap-1	NN	NN	_	16	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	4	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NF-AT	nf-at	NN	NN	_	7	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	important	important	JJ	JJ	_	26	advcl	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	normal	normal	JJ	JJ	_	20	amod	_	_
20	induction	induction	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IL-2	il-2	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	26	punct	_	_
24	it	it	PRP	PRP	_	26	nsubj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	unknown	unknown	JJ	JJ	_	0	root	_	_
27	if	if	IN	IN	_	41	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	age-related	age-related	JJ	JJ	_	30	amod	_	_
30	decline	decline	NN	NN	_	41	nsubjpass	_	_
31	in	in	IN	IN	_	33	case	_	_
32	IL-2	il-2	NN	NN	_	33	compound	_	_
33	production	production	NN	NN	_	30	nmod	_	_
34	by	by	IN	IN	_	38	case	_	_
35	activated	activate	VBN	VBN	_	38	amod	_	_
36	human	human	JJ	JJ	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	33	nmod	_	_
39	may	may	MD	MD	_	41	aux	_	_
40	be	be	VB	VB	_	41	auxpass	_	_
41	associated	associate	VBN	VBN	_	26	advcl	_	_
42	with	with	IN	IN	_	43	case	_	_
43	aberrancies	aberrancy	NNS	NNS	_	41	nmod	_	_
44	in	in	IN	IN	_	47	case	_	_
45	transcriptional	transcriptional	JJ	JJ	_	47	amod	_	_
46	regulatory	regulatory	JJ	JJ	_	47	amod	_	_
47	proteins	protein	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	26	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	27	nmod	_	_
5	,	,	,	,	_	27	punct	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	27	nsubjpass	_	_
8	by	by	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	25	case	_	_
12	elderly	elderly	JJ	JJ	_	25	amod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	mean	mean	NN	NN	_	16	dep	_	_
15	78	78	CD	CD	_	16	nummod	_	_
16	years	year	NNS	NNS	_	12	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	young	young	JJ	JJ	_	12	conj	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	mean	mean	NN	NN	_	23	dep	_	_
22	37	37	CD	CD	_	23	nummod	_	_
23	years	year	NNS	NNS	_	19	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	humans	human	NNS	NNS	_	10	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	measured	measure	VBN	VBN	_	0	root	_	_
28	in	in	IN	IN	_	29	case	_	_
29	cultures	culture	NNS	NNS	_	27	nmod	_	_
30	stimulated	stimulate	VBN	VBN	_	29	acl	_	_
31	with	with	IN	IN	_	32	case	_	_
32	PHA	pha	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	PHA	pha	NN	NN	_	32	conj	_	_
35	plus	plus	CC	CC	_	34	cc	_	_
36	PMA	pma	NN	NN	_	34	conj	_	_
37	,	,	,	,	_	32	punct	_	_
38	crosslinked	crosslink	VBN	VBN	_	41	amod	_	_
39	anti-CD3	anti-cd3	JJ	JJ	_	41	amod	_	_
40	mAB	mab	NN	NN	_	41	compound	_	_
41	OKT3	okt3	NN	NN	_	32	conj	_	_
42	plus	plus	CC	CC	_	41	cc	_	_
43	PMA	pma	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	32	punct	_	_
45	or	or	CC	CC	_	32	cc	_	_
46	PMA	pma	NN	NN	_	32	conj	_	_
47	plus	plus	CC	CC	_	46	cc	_	_
48	ionomycin	ionomycin	NN	NN	_	46	conj	_	_
49	.	.	.	.	_	27	punct	_	_

1	Substantial	substantial	JJ	JJ	_	2	amod	_	_
2	decreases	decrease	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	cultures	culture	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	16	case	_	_
12	7	7	CD	CD	_	14	compound	_	_
13	of	of	IN	IN	_	14	advmod	_	_
14	12	12	CD	CD	_	16	nummod	_	_
15	elderly	elderly	JJ	JJ	_	16	amod	_	_
16	individuals	individual	NNS	NNS	_	10	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	response	response	NN	NN	_	22	dep	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	different	different	JJ	JJ	_	22	amod	_	_
22	stimuli	stimulus	NNS	NNS	_	7	nmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	whereas	whereas	IN	IN	_	7	dep	_	_
25	the	the	DT	DT	_	26	det	_	_
26	levels	level	NNS	NNS	_	39	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	produced	produce	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	33	case	_	_
31	stimulated	stimulate	VBN	VBN	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	from	from	IN	IN	_	37	case	_	_
35	other	other	JJ	JJ	_	37	amod	_	_
36	elderly	elderly	JJ	JJ	_	37	amod	_	_
37	individuals	individual	NNS	NNS	_	33	nmod	_	_
38	were	be	VBD	VBD	_	39	cop	_	_
39	equivalent	equivalent	JJ	JJ	_	7	parataxis	_	_
40	to	to	TO	TO	_	41	case	_	_
41	those	those	DT	DT	_	39	nmod	_	_
42	observed	observe	VBN	VBN	_	41	acl	_	_
43	for	for	IN	IN	_	46	case	_	_
44	stimulated	stimulate	VBN	VBN	_	46	amod	_	_
45	T	t	NN	NN	_	46	compound	_	_
46	cells	cell	NNS	NNS	_	42	nmod	_	_
47	of	of	IN	IN	_	49	case	_	_
48	young	young	JJ	JJ	_	49	amod	_	_
49	subjects	subject	NNS	NNS	_	46	nmod	_	_
50	.	.	.	.	_	7	punct	_	_

1	Analyses	analysis	NNS	NNS	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	extracts	extract	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	10	case	_	_
6	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
7	DNA	dna	NN	NN	_	10	compound	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assays	assay	NNS	NNS	_	1	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	25	mark	_	_
13	decreased	decrease	VBN	VBN	_	15	amod	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	25	nsubjpass	_	_
16	by	by	IN	IN	_	19	case	_	_
17	stimulated	stimulate	VBN	VBN	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	elderly	elderly	JJ	JJ	_	22	amod	_	_
22	individuals	individual	NNS	NNS	_	19	nmod	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	closely	closely	RB	RB	_	25	advmod	_	_
25	associated	associate	VBN	VBN	_	11	ccomp	_	_
26	with	with	IN	IN	_	27	case	_	_
27	impairments	impairment	NNS	NNS	_	25	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	activation	activation	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	both	both	CC	CC	_	33	cc:preconj	_	_
33	AP-1	ap-1	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	NF-AT	nf-at	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	11	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	15	nsubj	_	_
6	from	from	IN	IN	_	8	case	_	_
7	elderly	elderly	JJ	JJ	_	8	amod	_	_
8	subjects	subject	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	nmod	_	_
15	exhibited	exhibit	VBD	VBD	_	0	root	_	_
16	normal	normal	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	AP-1	ap-1	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NF-AT	nf-at	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	15	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	competition	competition	NN	NN	_	8	compound	_	_
8	experiments	experiment	NNS	NNS	_	5	nmod	_	_
9	analyzing	analyze	VBG	VBG	_	8	acl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	components	component	NNS	NNS	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-AT	nf-at	NN	NN	_	12	nmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	24	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	age-related	age-related	JJ	JJ	_	19	amod	_	_
19	reductions	reduction	NNS	NNS	_	24	nsubj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	stimulus-dependent	stimulus-dependent	JJ	JJ	_	23	amod	_	_
22	NF-AT	nf-at	NN	NN	_	23	compound	_	_
23	complexes	complex	NNS	NNS	_	19	nmod	_	_
24	corresponded	correspond	VBD	VBD	_	15	ccomp	_	_
25	to	to	TO	TO	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	slow	slow	JJ	JJ	_	28	dep	_	_
28	migrating	migrate	VBG	VBG	_	29	amod	_	_
29	complexes	complex	NNS	NNS	_	24	nmod	_	_
30	that	that	WDT	WDT	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	composed	compose	VBN	VBN	_	29	acl:relcl	_	_
33	of	of	IN	IN	_	35	case	_	_
34	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	35	compound	_	_
35	AP-1	ap-1	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	resting	resting	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	stimulated	stimulated	JJ	JJ	_	2	conj	_	_
5	levels	level	NNS	NNS	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF	nf	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	reduced	reduce	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	certain	certain	JJ	JJ	_	18	amod	_	_
17	elderly	elderly	JJ	JJ	_	18	amod	_	_
18	individuals	individual	NNS	NNS	_	14	nmod	_	_
19	;	;	:	:	_	11	punct	_	_
20	however	however	RB	RB	_	29	advmod	_	_
21	,	,	,	,	_	29	punct	_	_
22	alterations	alteration	NNS	NNS	_	29	nsubj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	NF	nf	NN	NN	_	26	compound	_	_
25	kappa	kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	22	nmod	_	_
27	did	do	VBD	VBD	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	correlate	correlate	VB	VB	_	11	parataxis	_	_
30	with	with	IN	IN	_	31	case	_	_
31	changes	change	NNS	NNS	_	29	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	IL-2	il-2	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	29	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	age-related	age-related	JJ	JJ	_	8	amod	_	_
8	impairments	impairment	NNS	NNS	_	18	nsubjpass	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	AP-1	ap-1	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-AT	nf-at	NN	NN	_	13	conj	_	_
16	are	be	VBP	VBP	_	18	auxpass	_	_
17	closely	closely	RB	RB	_	18	advmod	_	_
18	associated	associate	VBN	VBN	_	5	ccomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	decreased	decrease	VBN	VBN	_	21	amod	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	5	cc	_	_
25	further	further	RB	RB	_	26	advmod	_	_
26	suggest	suggest	VBP	VBP	_	5	conj	_	_
27	that	that	IN	IN	_	43	mark	_	_
28	aberrancies	aberrancy	NNS	NNS	_	43	nsubj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	signaling	signaling	NN	NN	_	32	compound	_	_
32	pathways	pathway	NNS	NNS	_	28	nmod	_	_
33	important	important	JJ	JJ	_	28	amod	_	_
34	for	for	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	induction	induction	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	41	case	_	_
38	transcriptionally	transcriptionally	RB	RB	_	39	advmod	_	_
39	active	active	JJ	JJ	_	41	amod	_	_
40	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	41	compound	_	_
41	AP-1	ap-1	NN	NN	_	36	nmod	_	_
42	may	may	MD	MD	_	43	aux	_	_
43	contribute	contribute	VB	VB	_	26	ccomp	_	_
44	to	to	TO	TO	_	47	case	_	_
45	the	the	DT	DT	_	47	det	_	_
46	impaired	impaired	JJ	JJ	_	47	amod	_	_
47	activation	activation	NN	NN	_	43	nmod	_	_
48	of	of	IN	IN	_	49	case	_	_
49	NF-AT	nf-at	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	5	punct	_	_

1	Inhibitory	inhibitory	JJ	JJ	_	2	amod	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E3330	e3330	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	quinone	quinone	NN	NN	_	4	appos	_	_
9	derivative	derivative	JJ	JJ	_	8	amod	_	_
10	able	able	JJ	JJ	_	8	amod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	suppress	suppress	VB	VB	_	10	xcomp	_	_
13	tumor	tumor	NN	NN	_	15	compound	_	_
14	necrosis	necrosis	NN	NN	_	15	compound	_	_
15	factor-alpha	factor-alpha	NN	NN	_	16	compound	_	_
16	generation	generation	NN	NN	_	12	dobj	_	_
17	,	,	,	,	_	2	punct	_	_
18	on	on	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	2	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
22	factor-kappa	factor-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	(2E)-3--LSB-5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)-RSB--2-nonyl-2-propenoic	(2e)-3--lsb-5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)-rsb--2-nonyl-2-propenoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	E3330	e3330	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	agent	agent	NN	NN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	hepatoprotective	hepatoprotective	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	E3330	e3330	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	18	case	_	_
11	tumor	tumor	NN	NN	_	18	compound	_	_
12	necrosis	necrosis	NN	NN	_	18	compound	_	_
13	factor	factor	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	TNF	tnf	NN	NN	_	18	compound	_	_
16	)	)	-RRB-	-RRB-	_	18	punct	_	_
17	-alpha	-alpha	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	9	nmod	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	on	on	IN	IN	_	28	case	_	_
21	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
22	factor	factor	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	NF	nf	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	-kappa	-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	9	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	run-on	run-on	JJ	JJ	_	1	dep	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	E3330	e3330	NN	NN	_	7	nsubj	_	_
7	decreases	decrease	VBZ	VBZ	_	4	ccomp	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	9	nmod	_	_
13	induced	induce	VBN	VBN	_	9	acl	_	_
14	by	by	IN	IN	_	19	case	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LPS	lps	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	stimulation	stimulation	NN	NN	_	13	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
23	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	constructed	construct	VBD	VBD	_	2	parataxis	_	_
9	a	a	DT	DT	_	18	det	_	_
10	secreted-type	secreted-type	JJ	JJ	_	18	amod	_	_
11	placental	placental	JJ	JJ	_	18	amod	_	_
12	alkaline	alkaline	NN	NN	_	18	compound	_	_
13	phosphatase	phosphatase	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	PLAP	plap	NN	NN	_	18	compound	_	_
16	)	)	-RRB-	-RRB-	_	18	punct	_	_
17	reporter	reporter	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	8	dobj	_	_
19	whose	whose	WP$	WP$	_	20	nmod:poss	_	_
20	transcription	transcription	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	controlled	control	VBN	VBN	_	18	acl:relcl	_	_
23	by	by	IN	IN	_	28	case	_	_
24	a	a	DT	DT	_	28	det	_	_
25	1.4-kb	1.4-kb	JJ	JJ	_	28	amod	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	TNF-alpha	tnf-alpha	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	stable	stable	JJ	JJ	_	3	amod	_	_
3	transformant	transformant	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	PLAP	plap	NN	NN	_	8	compound	_	_
7	reporter	reporter	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	derived	derive	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	9	nmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	very	very	RB	RB	_	17	advmod	_	_
17	little	little	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	15	dobj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	18	nmod	_	_
22	before	before	IN	IN	_	23	case	_	_
23	stimulation	stimulation	NN	NN	_	15	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	whereas	whereas	IN	IN	_	28	mark	_	_
26	LPS	lps	NN	NN	_	27	compound	_	_
27	stimulation	stimulation	NN	NN	_	28	nsubj	_	_
28	led	lead	VBD	VBD	_	15	advcl	_	_
29	to	to	TO	TO	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	dramatic	dramatic	JJ	JJ	_	32	amod	_	_
32	increase	increase	NN	NN	_	28	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	PLAP	plap	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	E3330	e3330	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	6	det	_	_
4	induced	induce	VBN	VBN	_	6	amod	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dose-dependent	dose-dependent	JJ	JJ	_	10	amod	_	_
10	manner	manner	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	are	be	VBP	VBP	_	0	root	_	_
3	four	four	CD	CD	_	8	nummod	_	_
4	putative	putative	JJ	JJ	_	8	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	2	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B-1	b-1	NN	NN	_	8	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B-2	b-2	NN	NN	_	11	appos	_	_
15	,	,	,	,	_	11	punct	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B-3	b-3	NN	NN	_	11	appos	_	_
18	,	,	,	,	_	11	punct	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B-4	b-4	NN	NN	_	11	appos	_	_
21	)	)	-RRB-	-RRB-	_	11	punct	_	_
22	in	in	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	2	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	8	advcl	_	_
3	mutated	mutate	VBN	VBN	_	5	amod	_	_
4	promoter-PLAP	promoter-plap	JJ	JJ	_	5	amod	_	_
5	plasmids	plasmid	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	established	establish	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	these	these	DT	DT	_	13	det	_	_
11	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	15	nsubj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	necessary	necessary	JJ	JJ	_	8	ccomp	_	_
16	for	for	IN	IN	_	17	case	_	_
17	induction	induction	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	17	nmod	_	_
21	on	on	IN	IN	_	22	case	_	_
22	stimulation	stimulation	NN	NN	_	17	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	LPS	lps	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	gel	gel	NN	NN	_	4	compound	_	_
3	retardation	retardation	NN	NN	_	4	compound	_	_
4	experiment	experiment	NN	NN	_	9	nsubj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	synthetic	synthetic	JJ	JJ	_	8	amod	_	_
7	double-stranded	double-stranded	JJ	JJ	_	6	dep	_	_
8	oligonucleotides	oligonucleotide	NNS	NNS	_	4	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	18	nsubj	_	_
14	consisting	consist	VBG	VBG	_	13	acl	_	_
15	of	of	IN	IN	_	17	case	_	_
16	p50/p65	p50/p65	NN	NN	_	17	compound	_	_
17	heterodimer	heterodimer	NN	NN	_	14	nmod	_	_
18	bound	bind	VBN	VBN	_	9	ccomp	_	_
19	to	to	TO	TO	_	26	case	_	_
20	all	all	DT	DT	_	26	det	_	_
21	four	four	CD	CD	_	26	nummod	_	_
22	putative	putative	JJ	JJ	_	26	amod	_	_
23	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
24	B	b	NN	NN	_	26	compound	_	_
25	DNA	dna	NN	NN	_	26	compound	_	_
26	probes	probe	NNS	NNS	_	18	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	suggesting	suggest	VBG	VBG	_	18	xcomp	_	_
29	that	that	IN	IN	_	37	mark	_	_
30	all	all	DT	DT	_	36	det	_	_
31	four	four	CD	CD	_	36	nummod	_	_
32	putative	putative	JJ	JJ	_	36	amod	_	_
33	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	recognition	recognition	NN	NN	_	36	compound	_	_
36	sites	site	NNS	NNS	_	37	nsubj	_	_
37	play	play	VBP	VBP	_	28	ccomp	_	_
38	an	a	DT	DT	_	40	det	_	_
39	important	important	JJ	JJ	_	40	amod	_	_
40	role	role	NN	NN	_	37	dobj	_	_
41	in	in	IN	IN	_	44	case	_	_
42	inducible	inducible	JJ	JJ	_	44	amod	_	_
43	TNF-alpha	tnf-alpha	NN	NN	_	44	compound	_	_
44	expression	expression	NN	NN	_	37	nmod	_	_
45	.	.	.	.	_	9	punct	_	_

1	E3330	e3330	NN	NN	_	2	nsubj	_	_
2	decreased	decrease	VBD	VBD	_	0	root	_	_
3	activated	activate	VBN	VBN	_	5	amod	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	nuclei	nucleus	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	suggesting	suggest	VBG	VBG	_	2	advcl	_	_
10	that	that	IN	IN	_	12	mark	_	_
11	E3330	e3330	NN	NN	_	12	nsubj	_	_
12	inhibits	inhibit	VBZ	VBZ	_	9	ccomp	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	dobj	_	_
16	and/or	and/or	CC	CC	_	15	cc	_	_
17	translocation	translocation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nuclei	nucleus	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blotting	blotting	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	9	nsubj	_	_
4	with	with	IN	IN	_	8	case	_	_
5	anti-I	anti-i	JJ	JJ	_	8	amod	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B-alpha	b-alpha	NN	NN	_	8	compound	_	_
8	antibody	antibody	NN	NN	_	3	nmod	_	_
9	indicated	indicate	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	12	mark	_	_
11	E3330	e3330	NN	NN	_	12	nsubj	_	_
12	inhibited	inhibit	VBD	VBD	_	9	ccomp	_	_
13	degradation	degradation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	I	i	NN	NN	_	17	compound	_	_
16	kappa	kappa	NN	NN	_	17	compound	_	_
17	B-alpha	b-alpha	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	23	nsubj	_	_
20	is	be	VBZ	VBZ	_	23	cop	_	_
21	an	a	DT	DT	_	23	det	_	_
22	inhibitory	inhibitory	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	17	acl:relcl	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	12	punct	_	_
28	in	in	IN	IN	_	30	case	_	_
29	LPS-stimulated	lps-stimulated	JJ	JJ	_	30	amod	_	_
30	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	E3330	e3330	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	suppress	suppress	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	production	production	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	active	active	JJ	JJ	_	9	amod	_	_
8	oxygen	oxygen	NN	NN	_	9	compound	_	_
9	species	species	NNS	NNS	_	5	nmod	_	_
10	serving	serve	VBG	VBG	_	9	acl	_	_
11	as	as	IN	IN	_	13	case	_	_
12	common	common	JJ	JJ	_	13	amod	_	_
13	messengers	messenger	NNS	NNS	_	10	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	activate	activate	VB	VB	_	3	xcomp	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	appearance	appearance	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	factor	factor	NN	NN	_	2	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	CD28	cd28	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	7	dobj	_	_
12	within	within	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	interleukin-2	interleukin-2	NN	NN	_	15	compound	_	_
15	enhancer	enhancer	NN	NN	_	11	nmod	_	_
16	correlates	correlate	VBZ	VBZ	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	interleukin-2	interleukin-2	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	combined	combined	JJ	JJ	_	8	amod	_	_
8	signaling	signaling	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	costimulatory	costimulatory	JJ	JJ	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	13	conj	_	_
17	such	such	JJ	JJ	_	19	case	_	_
18	as	as	IN	IN	_	17	mwe	_	_
19	CD28	cd28	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	produce	produce	VB	VB	_	2	acl	_	_
8	interleukin-2	interleukin-2	NN	NN	_	7	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-2	il-2	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	critical	critical	JJ	JJ	_	16	amod	_	_
15	control	control	NN	NN	_	16	compound	_	_
16	point	point	NN	NN	_	0	root	_	_
17	in	in	IN	IN	_	20	case	_	_
18	T	t	NN	NN	_	20	compound	_	_
19	lymphocyte	lymphocyte	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-2	il-2	NN	NN	_	3	compound	_	_
3	enhancer	enhancer	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	motif	motif	NN	NN	_	4	dobj	_	_
8	named	name	VBN	VBN	_	7	acl	_	_
9	CD28	cd28	NN	NN	_	11	compound	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	8	xcomp	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	CD28RE	cd28re	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	serves	serve	VBZ	VBZ	_	7	acl:relcl	_	_
17	a	a	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	16	dobj	_	_
19	as	as	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	target	target	NN	NN	_	18	nmod	_	_
22	for	for	IN	IN	_	27	case	_	_
23	mitogenic	mitogenic	JJ	JJ	_	27	amod	_	_
24	T	t	NN	NN	_	27	compound	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	activation	activation	NN	NN	_	27	compound	_	_
27	signals	signal	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CD28RE	cd28re	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	4	nsubj	_	_
4	reveals	reveal	VBZ	VBZ	_	0	root	_	_
5	similarity	similarity	NN	NN	_	4	dobj	_	_
6	to	to	TO	TO	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	consensus	consensus	NN	NN	_	11	compound	_	_
9	kappaB	kappab	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	CD28RE	cd28re	NN	NN	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	3	ccomp	_	_
7	an	a	DT	DT	_	9	det	_	_
8	inducible	inducible	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	with	with	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	mass	mass	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	approximately	approximately	RB	RB	_	16	advmod	_	_
16	35	35	CD	CD	_	17	nummod	_	_
17	kDa	kda	NN	NN	_	13	nmod	_	_
18	called	call	VBN	VBN	_	9	acl	_	_
19	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
20	factor	factor	NN	NN	_	24	compound	_	_
21	of	of	IN	IN	_	24	amod	_	_
22	mitogenic-activated	mitogenic-activated	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	18	xcomp	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	NF-MATp35	nf-matp35	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	that	that	WDT	WDT	_	31	nsubj	_	_
29	is	be	VBZ	VBZ	_	31	cop	_	_
30	clearly	clearly	RB	RB	_	31	advmod	_	_
31	different	different	JJ	JJ	_	3	dep	_	_
32	from	from	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	known	known	JJ	JJ	_	37	amod	_	_
35	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	37	compound	_	_
36	family	family	NN	NN	_	37	compound	_	_
37	members	member	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-MATp35	nf-matp35	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	depend	depend	VB	VB	_	5	xcomp	_	_
8	on	on	IN	IN	_	12	case	_	_
9	de	de	FW	FW	_	12	amod	_	_
10	novo	novo	FW	FW	_	9	dep	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	restricted	restricted	JJ	JJ	_	5	conj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	received	receive	VBD	VBD	_	18	acl:relcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	mitogenic	mitogenic	JJ	JJ	_	23	amod	_	_
23	combination	combination	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	stimuli	stimulus	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	23	punct	_	_
29	not	not	RB	RB	_	23	neg	_	_
30	necessarily	necessarily	RB	RB	_	23	advmod	_	_
31	including	include	VBG	VBG	_	33	case	_	_
32	CD28	cd28	NN	NN	_	33	compound	_	_
33	signaling	signaling	NN	NN	_	23	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Nonmitogenic	nonmitogenic	JJ	JJ	_	4	amod	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	result	result	VB	VB	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	appearance	appearance	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-MATp35	nf-matp35	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	mitogenic	mitogenic	JJ	JJ	_	6	amod	_	_
6	combinations	combination	NNS	NNS	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	activation	activation	NN	NN	_	11	compound	_	_
11	signals	signal	NNS	NNS	_	6	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	integrated	integrate	VBN	VBN	_	3	ccomp	_	_
14	at	at	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	level	level	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-MATp35	nf-matp35	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Similar	similar	JJ	JJ	_	11	advmod	_	_
2	to	to	TO	TO	_	4	case	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	effect	effect	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	11	nsubj	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	induction	induction	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NF-MATp35	nf-matp35	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	appearance	appearance	NN	NN	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-MATp35	nf-matp35	NN	NN	_	10	nmod	_	_
13	shows	show	VBZ	VBZ	_	6	ccomp	_	_
14	excellent	excellent	JJ	JJ	_	15	amod	_	_
15	correlation	correlation	NN	NN	_	13	dobj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	which	which	WDT	WDT	_	24	nsubj	_	_
21	is	be	VBZ	VBZ	_	24	cop	_	_
22	a	a	DT	DT	_	24	det	_	_
23	unique	unique	JJ	JJ	_	24	amod	_	_
24	characteristic	characteristic	NN	NN	_	13	dep	_	_
25	among	among	IN	IN	_	27	case	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	implicated	implicate	VBN	VBN	_	27	acl	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	control	control	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	IL-2	il-2	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	1	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
5	JAK2	jak2	NN	NN	_	7	compound	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	4	dobj	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	rapidly	rapidly	RB	RB	_	10	advmod	_	_
10	activates	activate	VBZ	VBZ	_	4	conj	_	_
11	p93fes	p93fes	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	STAT1	stat1	NN	NN	_	14	compound	_	_
14	p91	p91	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	STAT3	stat3	NN	NN	_	18	compound	_	_
18	p92	p92	NN	NN	_	11	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	polymorphonuclear	polymorphonuclear	JJ	JJ	_	21	amod	_	_
21	leukocytes	leukocyte	NNS	NNS	_	11	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	8	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	supports	support	VBZ	VBZ	_	0	root	_	_
9	proliferation	proliferation	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	differentiation	differentiation	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	functional	functional	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	9	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	hemopoietic	hemopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	9	nmod	_	_
19	by	by	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	interaction	interaction	NN	NN	_	8	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	heterodimeric	heterodimeric	JJ	JJ	_	25	amod	_	_
25	receptor	receptor	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	GM-CSF	gm-csf	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	devoid	devoid	JJ	JJ	_	23	advcl	_	_
6	of	of	IN	IN	_	10	case	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	kinase	kinase	NN	NN	_	10	compound	_	_
9	enzymatic	enzymatic	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	23	punct	_	_
12	GM-CSF-induced	gm-csf-induced	JJ	JJ	_	16	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	polymorphonuclear	polymorphonuclear	JJ	JJ	_	16	amod	_	_
16	leukocytes	leukocyte	NNS	NNS	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PMN	pmn	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	functional	functional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	mediated	mediate	VBN	VBN	_	0	root	_	_
24	by	by	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	phosphorylation	phosphorylation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	large	large	JJ	JJ	_	30	amod	_	_
30	number	number	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	intracellular	intracellular	JJ	JJ	_	34	amod	_	_
33	signaling	signaling	NN	NN	_	34	compound	_	_
34	molecules	molecule	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	JAK2	jak2	NN	NN	_	7	nsubj	_	_
7	becomes	become	VBZ	VBZ	_	4	ccomp	_	_
8	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	7	xcomp	_	_
9	in	in	IN	IN	_	10	case	_	_
10	response	response	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	GM-CSF	gm-csf	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	PMN	pmn	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	33	mark	_	_
8	also	also	RB	RB	_	33	advmod	_	_
9	the	the	DT	DT	_	11	det	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transducers	transducer	NNS	NNS	_	33	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activators	activator	NNS	NNS	_	20	compound	_	_
14	of	of	IN	IN	_	20	amod	_	_
15	transcription	transcription	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	STAT	stat	NN	NN	_	20	compound	_	_
18	)	)	-RRB-	-RRB-	_	20	punct	_	_
19	family	family	NN	NN	_	20	compound	_	_
20	members	member	NNS	NNS	_	11	conj	_	_
21	STAT1	stat1	NN	NN	_	22	compound	_	_
22	p91	p91	NN	NN	_	11	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	STAT3	stat3	NN	NN	_	25	compound	_	_
25	p92	p92	NN	NN	_	22	conj	_	_
26	and	and	CC	CC	_	11	cc	_	_
27	the	the	DT	DT	_	28	det	_	_
28	product	product	NN	NN	_	11	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	c-fps/fes	c-fps/fes	NN	NN	_	32	compound	_	_
32	protooncogene	protooncogene	NN	NN	_	28	nmod	_	_
33	become	become	VBN	VBN	_	6	ccomp	_	_
34	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	33	xcomp	_	_
35	upon	upon	IN	IN	_	37	case	_	_
36	GM-CSF	gm-csf	NN	NN	_	37	compound	_	_
37	stimulation	stimulation	NN	NN	_	34	nmod	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	physically	physically	RB	RB	_	34	advmod	_	_
40	associated	associate	VBN	VBN	_	34	conj	_	_
41	with	with	IN	IN	_	47	case	_	_
42	both	both	CC	CC	_	47	cc:preconj	_	_
43	GM-CSF	gm-csf	NN	NN	_	47	compound	_	_
44	receptor	receptor	NN	NN	_	47	compound	_	_
45	beta	beta	NN	NN	_	47	compound	_	_
46	common	common	JJ	JJ	_	47	amod	_	_
47	subunit	subunit	NN	NN	_	40	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	JAK2	jak2	NN	NN	_	47	conj	_	_
50	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	GM-CSF	gm-csf	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	able	able	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	induce	induce	VB	VB	_	4	xcomp	_	_
7	JAK2	jak2	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	p93fes	p93fes	NN	NN	_	7	conj	_	_
10	catalytic	catalytic	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	6	dobj	_	_
12	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	association	association	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
10	receptor	receptor	NN	NN	_	13	compound	_	_
11	beta	beta	NN	NN	_	13	compound	_	_
12	common	common	JJ	JJ	_	13	amod	_	_
13	subunit	subunit	NN	NN	_	6	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	JAK2	jak2	NN	NN	_	6	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	ligand-dependent	ligand-dependent	JJ	JJ	_	3	ccomp	_	_
18	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	GM-CSF	gm-csf	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	complex	complex	NN	NN	_	6	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	9	acl:relcl	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	p91	p91	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	p92	p92	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	new	new	JJ	JJ	_	8	amod	_	_
6	signal	signal	NN	NN	_	8	compound	_	_
7	transduction	transduction	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	3	dobj	_	_
9	activated	activate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	GM-CSF	gm-csf	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	provide	provide	VBP	VBP	_	3	conj	_	_
14	a	a	DT	DT	_	15	det	_	_
15	mechanism	mechanism	NN	NN	_	13	dobj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	rapid	rapid	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	GM-CSF-stimulated	gm-csf-stimulated	JJ	JJ	_	24	amod	_	_
24	PMN	pmn	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Abundant	abundant	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
5	transcription	transcription	NN	NN	_	9	compound	_	_
6	factor	factor	NN	NN	_	9	compound	_	_
7	P45	p45	NN	NN	_	9	compound	_	_
8	NF-E2	nf-e2	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
13	granurocytes	granurocyte	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	NF-E2	nf-e2	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	crucial	crucial	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	regulation	regulation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	erythroid-specific	erythroid-specific	JJ	JJ	_	11	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	p45	p45	NN	NN	_	2	compound	_	_
2	subunit	subunit	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-E2	nf-e2	NN	NN	_	2	nmod	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	basic-leucine	basic-leucine	NN	NN	_	9	compound	_	_
8	zipper	zipper	NN	NN	_	9	compound	_	_
9	domain	domain	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	dimerizes	dimerize	VBZ	VBZ	_	5	conj	_	_
12	with	with	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	small	small	JJ	JJ	_	17	amod	_	_
15	Maf	maf	NN	NN	_	17	compound	_	_
16	family	family	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	11	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	form	form	VB	VB	_	11	xcomp	_	_
20	functional	functional	JJ	JJ	_	22	amod	_	_
21	NF-E2	nf-e2	NN	NN	_	22	compound	_	_
22	complex	complex	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	5	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	p45	p45	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	22	advcl	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	restricted	restricted	JJ	JJ	_	5	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	megakaryocytes	megakaryocyte	NNS	NNS	_	11	conj	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	mast	mast	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
19	lineage	lineage	NN	NN	_	11	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	we	we	PRP	PRP	_	22	nsubj	_	_
22	found	find	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	study	study	NN	NN	_	22	nmod	_	_
26	that	that	IN	IN	_	31	mark	_	_
27	p45	p45	NN	NN	_	28	compound	_	_
28	mRNA	mrna	NN	NN	_	31	nsubjpass	_	_
29	is	be	VBZ	VBZ	_	31	auxpass	_	_
30	abundantly	abundantly	RB	RB	_	31	advmod	_	_
31	transcribed	transcribe	VBN	VBN	_	22	ccomp	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	granulocyte	granulocyte	NN	NN	_	35	compound	_	_
35	fraction	fraction	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	human	human	JJ	JJ	_	40	amod	_	_
38	peripheral	peripheral	JJ	JJ	_	40	amod	_	_
39	blood	blood	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	35	nmod	_	_
41	.	.	.	.	_	22	punct	_	_

1	As	as	IN	IN	_	3	mark	_	_
2	neutrophils	neutrophil	NNS	NNS	_	3	nsubj	_	_
3	occupy	occupy	VBP	VBP	_	0	root	_	_
4	approximately	approximately	RB	RB	_	5	advmod	_	_
5	92	92	CD	CD	_	6	nummod	_	_
6	%	%	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	granulocyte	granulocyte	NN	NN	_	12	compound	_	_
12	fraction	fraction	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	3	mark	_	_
2	neutrophils	neutrophil	NNS	NNS	_	3	nsubj	_	_
3	occupy	occupy	VBP	VBP	_	20	advcl	_	_
4	approximately	approximately	RB	RB	_	5	advmod	_	_
5	92	92	CD	CD	_	6	nummod	_	_
6	%	%	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	fraction	fraction	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	20	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	20	nsubj	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	p45	p45	NN	NN	_	16	dobj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	most	most	RBS	RBS	_	20	advmod	_	_
20	likely	likely	JJ	JJ	_	0	root	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	neutrophils	neutrophil	NNS	NNS	_	20	xcomp	_	_
24	.	.	.	.	_	20	punct	_	_

1	p45	p45	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	HL-60	hl-60	NN	NN	_	8	compound	_	_
8	promyelocytes	promyelocyte	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	albeit	albeit	IN	IN	_	16	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	expression	expression	NN	NN	_	13	compound	_	_
13	level	level	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	much	much	RB	RB	_	16	advmod	_	_
16	lower	lower	JJR	JJR	_	5	advcl	_	_
17	than	than	IN	IN	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	granulocyte	granulocyte	NN	NN	_	22	compound	_	_
22	fraction	fraction	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	HL-60	hl-60	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	express	express	VB	VB	_	4	xcomp	_	_
7	mafK	mafk	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	indicating	indicate	VBG	VBG	_	4	advcl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	genuine	genuine	JJ	JJ	_	16	amod	_	_
15	NF-E2	nf-e2	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	p45	p45	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	transcribed	transcribe	VBN	VBN	_	27	advcl	_	_
6	from	from	IN	IN	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	promoters	promoter	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	aNF-E2	anf-e2	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	9	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	fNF-E2	fnf-e2	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	in	in	IN	IN	_	18	case	_	_
18	erythroid	erythroid	JJ	JJ	_	9	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	megakaryocytic	megakaryocytic	JJ	JJ	_	18	conj	_	_
21	lineage	lineage	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	dep	_	_
23	,	,	,	,	_	27	punct	_	_
24	p45	p45	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	transcribed	transcribe	VBN	VBN	_	0	root	_	_
28	only	only	RB	RB	_	31	advmod	_	_
29	from	from	IN	IN	_	31	case	_	_
30	aNF-E2	anf-e2	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p45	p45	NN	NN	_	2	nmod	_	_
5	megakaryocytic	megakaryocytic	JJ	JJ	_	7	amod	_	_
6	lineage	lineage	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	dep	_	_
8	,	,	,	,	_	4	punct	_	_
9	p45	p45	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	4	appos	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	transcribed	transcribe	VBN	VBN	_	0	root	_	_
13	only	only	RB	RB	_	16	advmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	aNF-E2	anf-e2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	p45	p45	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	neutrophils	neutrophil	NNS	NNS	_	2	nmod	_	_
9	declined	decline	VBD	VBD	_	0	root	_	_
10	rapidly	rapidly	RB	RB	_	9	advmod	_	_
11	after	after	IN	IN	_	12	case	_	_
12	transfer	transfer	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	in	in	FW	FW	_	19	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	culture	culture	NN	NN	_	12	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	G-CSF	g-csf	NN	NN	_	24	nsubj	_	_
22	could	could	MD	MD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	sustain	sustain	VB	VB	_	9	conj	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	from	from	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	down-regulation	down-regulation	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	9	punct	_	_
31	suggesting	suggest	VBG	VBG	_	9	parataxis	_	_
32	the	the	DT	DT	_	33	det	_	_
33	E2	e2	NN	NN	_	31	dobj	_	_
34	may	may	MD	MD	_	36	aux	_	_
35	also	also	RB	RB	_	36	advmod	_	_
36	participate	participate	VB	VB	_	31	dep	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	regulation	regulation	NN	NN	_	36	nmod	_	_
40	of	of	IN	IN	_	43	case	_	_
41	neutrophil-specific	neutrophil-specific	JJ	JJ	_	43	amod	_	_
42	gene	gene	NN	NN	_	43	compound	_	_
43	expression	expression	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	9	punct	_	_

1	Reversible	reversible	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	monoblastic	monoblastic	JJ	JJ	_	8	amod	_	_
6	leukemia	leukemia	NN	NN	_	8	compound	_	_
7	U937	u937	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	ML-9	ml-9	NN	NN	_	2	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
14	of	of	IN	IN	_	18	case	_	_
15	myosin	myosin	JJ	JJ	_	18	amod	_	_
16	light	light	JJ	JJ	_	18	amod	_	_
17	chain	chain	NN	NN	_	18	compound	_	_
18	kinase	kinase	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	monoblastic	monoblastic	JJ	JJ	_	5	amod	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	U937	u937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	differentiate	differentiate	VB	VB	_	7	xcomp	_	_
10	into	into	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	macrophages	macrophage	NNS	NNS	_	11	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	various	various	JJ	JJ	_	16	amod	_	_
16	agents	agent	NNS	NNS	_	7	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine	1-(5-chloronaphthalene-1-sulfonyl)-1h-hexahydro-1,4-diazepine	NN	NN	_	6	compound	_	_
6	hydrochloride	hydrochloride	NN	NN	_	19	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	ML-9	ml-9	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	an	a	DT	DT	_	12	det	_	_
12	inhibitor	inhibitor	NN	NN	_	6	appos	_	_
13	of	of	IN	IN	_	17	case	_	_
14	myosin	myosin	JJ	JJ	_	17	amod	_	_
15	light	light	JJ	JJ	_	17	amod	_	_
16	chain	chain	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
20	differentiation	differentiation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	monocytoid	monocytoid	NN	NN	_	25	compound	_	_
23	leukemia	leukemia	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	20	nmod	_	_
26	U937	u937	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	THP-1	thp-1	NN	NN	_	25	conj	_	_
29	but	but	CC	CC	_	25	cc	_	_
30	not	not	RB	RB	_	35	neg	_	_
31	of	of	IN	IN	_	35	case	_	_
32	myeloblastic	myeloblastic	JJ	JJ	_	35	amod	_	_
33	leukemic	leukemic	JJ	JJ	_	35	amod	_	_
34	ML-1	ml-1	NN	NN	_	35	compound	_	_
35	cell	cell	NN	NN	_	25	conj	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	erythroleukemia	erythroleukemia	NN	NN	_	39	compound	_	_
38	K562	k562	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	conj	_	_
40	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	further	further	RB	RB	_	8	advmod	_	_
8	analyzed	analyze	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ML-9	ml-9	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	comparison	comparison	NN	NN	_	8	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	that	that	DT	DT	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	1	1	CD	CD	_	20	nummod	_	_
19	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	20	compound	_	_
20	D3	d3	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	VD3	vd3	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	a	a	DT	DT	_	26	det	_	_
25	typical	typical	JJ	JJ	_	26	amod	_	_
26	inducer	inducer	NN	NN	_	20	dep	_	_
27	of	of	IN	IN	_	29	case	_	_
28	monocytic	monocytic	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	ML-9	ml-9	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	nitroblue	nitroblue	JJ	JJ	_	9	amod	_	_
4	tetrazolium	tetrazolium	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	NBT	nbt	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	-reducing	-reducing	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	2	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	9	nmod	_	_
13	more	more	RBR	RBR	_	14	advmod	_	_
14	rapidly	rapidly	RB	RB	_	2	advmod	_	_
15	than	than	IN	IN	_	16	mark	_	_
16	VD3	vd3	NN	NN	_	14	advcl	_	_
17	:	:	:	:	_	2	punct	_	_
18	This	this	DT	DT	_	20	det	_	_
19	differentiation	differentiation	NN	NN	_	20	compound	_	_
20	marker	marker	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	induced	induce	VBN	VBN	_	2	parataxis	_	_
23	significantly	significantly	RB	RB	_	22	advmod	_	_
24	after	after	IN	IN	_	25	case	_	_
25	incubation	incubation	NN	NN	_	22	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	ML-9	ml-9	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	VD3	vd3	NN	NN	_	27	conj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	4	4	CD	CD	_	32	nummod	_	_
32	hours	hour	NNS	NNS	_	25	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	1	1	CD	CD	_	35	nummod	_	_
35	day	day	NN	NN	_	32	conj	_	_
36	,	,	,	,	_	22	punct	_	_
37	respectively	respectively	RB	RB	_	22	advmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	ML-9	ml-9	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	alpha-naphthyl	alpha-naphthyl	JJ	JJ	_	6	amod	_	_
5	acetate	acetate	NN	NN	_	6	compound	_	_
6	esterase	esterase	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	ANAE	anae	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	activity	activity	NN	NN	_	3	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	another	another	DT	DT	_	15	det	_	_
13	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
14	differentiation	differentiation	NN	NN	_	15	compound	_	_
15	marker	marker	NN	NN	_	10	appos	_	_
16	,	,	,	,	_	3	punct	_	_
17	more	more	JJR	JJR	_	18	dep	_	_
18	rapidly	rapidly	RB	RB	_	3	advmod	_	_
19	than	than	IN	IN	_	20	mark	_	_
20	VD3	vd3	NN	NN	_	18	dep	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	maximum	maximum	JJ	JJ	_	3	amod	_	_
3	levels	level	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	markers	marker	NNS	NNS	_	3	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	ML-9	ml-9	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	comparable	comparable	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	those	those	DT	DT	_	11	nmod	_	_
14	induced	induce	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	VD3	vd3	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	but	but	CC	CC	_	11	cc	_	_
19	after	after	IN	IN	_	20	case	_	_
20	removal	removal	NN	NN	_	36	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	ML-9	ml-9	NN	NN	_	20	nmod	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	medium	medium	NN	NN	_	20	nmod	_	_
26	by	by	IN	IN	_	27	mark	_	_
27	washing	wash	VBG	VBG	_	20	acl	_	_
28	the	the	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	27	dobj	_	_
30	,	,	,	,	_	36	punct	_	_
31	the	the	DT	DT	_	32	det	_	_
32	expressions	expression	NNS	NNS	_	36	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	theses	theses	DT	DT	_	35	det	_	_
35	markers	marker	NNS	NNS	_	32	nmod	_	_
36	decreased	decrease	VBD	VBD	_	11	conj	_	_
37	within	within	IN	IN	_	39	case	_	_
38	4	4	CD	CD	_	39	nummod	_	_
39	hours	hour	NNS	NNS	_	36	nmod	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	reached	reach	VBD	VBD	_	36	conj	_	_
42	basal	basal	JJ	JJ	_	43	amod	_	_
43	levels	level	NNS	NNS	_	41	dobj	_	_
44	in	in	IN	IN	_	46	case	_	_
45	1	1	CD	CD	_	46	nummod	_	_
46	day	day	NN	NN	_	41	nmod	_	_
47	,	,	,	,	_	36	punct	_	_
48	indicating	indicate	VBG	VBG	_	36	advcl	_	_
49	that	that	IN	IN	_	59	mark	_	_
50	ML-9	ml-9	NN	NN	_	52	nmod:poss	_	_
51	's	's	POS	POS	_	52	case	_	_
52	induction	induction	NN	NN	_	59	nsubj	_	_
53	of	of	IN	IN	_	54	case	_	_
54	expression	expression	NN	NN	_	52	nmod	_	_
55	of	of	IN	IN	_	57	case	_	_
56	differentiation-associated	differentiation-associated	JJ	JJ	_	57	amod	_	_
57	phenotypes	phenotype	NNS	NNS	_	54	nmod	_	_
58	was	be	VBD	VBD	_	59	cop	_	_
59	reversible	reversible	JJ	JJ	_	48	ccomp	_	_
60	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	growth	growth	NN	NN	_	3	compound	_	_
3	inhibition	inhibition	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	U937	u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	ML-9	ml-9	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	reversible	reversible	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	another	another	DT	DT	_	7	det	_	_
7	line	line	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	monoblastic	monoblastic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	THP-1	thp-1	NN	NN	_	7	appos	_	_
14	.	.	.	.	_	4	punct	_	_

1	ML-9	ml-9	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	little	little	JJ	JJ	_	2	dobj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	no	no	DT	DT	_	3	conj	_	_
6	effect	effect	NN	NN	_	3	dep	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	morphology	morphology	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	but	but	CC	CC	_	2	cc	_	_
14	increased	increase	VBD	VBD	_	2	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	monocyte-macrophage	monocyte-macrophage	JJ	JJ	_	21	amod	_	_
19	lineage-associated	lineage-associated	JJ	JJ	_	21	amod	_	_
20	surface	surface	NN	NN	_	21	compound	_	_
21	antigen	antigen	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	CD14	cd14	NN	NN	_	21	appos	_	_
24	,	,	,	,	_	14	punct	_	_
25	to	to	TO	TO	_	27	case	_	_
26	some	some	DT	DT	_	27	det	_	_
27	extent	extent	NN	NN	_	14	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Irreversible	irreversible	JJ	JJ	_	3	amod	_	_
2	terminal	terminal	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	8	nsubjpass	_	_
4	induced	induce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	VD3	vd3	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	down	down	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	c-myc	c-myc	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	upregulation	upregulation	NN	NN	_	11	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	c-fos	c-fos	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	c-jun	c-jun	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	8	punct	_	_
27	but	but	CC	CC	_	8	cc	_	_
28	ML-9	ml-9	NN	NN	_	31	nsubj	_	_
29	did	do	VBD	VBD	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	affect	affect	VB	VB	_	8	conj	_	_
32	the	the	DT	DT	_	33	det	_	_
33	expression	expression	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	oncogenes	oncogene	NNS	NNS	_	33	nmod	_	_
37	appreciably	appreciably	RB	RB	_	31	advmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	ML-9-induced	ml-9-induced	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	reversible	reversible	JJ	JJ	_	0	root	_	_
6	when	when	WRB	WRB	_	10	advmod	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	cultured	culture	VBN	VBN	_	5	advcl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	cultured	culture	VBN	VBN	_	14	case	_	_
13	with	with	IN	IN	_	14	case	_	_
14	ML-9	ml-9	NN	NN	_	10	nmod	_	_
15	plus	plus	CC	CC	_	14	cc	_	_
16	an	a	DT	DT	_	18	det	_	_
17	anti-cancer	anti-cancer	JJ	JJ	_	18	amod	_	_
18	drug	drug	NN	NN	_	14	conj	_	_
19	such	such	JJ	JJ	_	21	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	1-beta-D-arabino-furanosylcytosine	1-beta-d-arabino-furanosylcytosine	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	daunomycin	daunomycin	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	it	it	PRP	PRP	_	2	nsubj	_	_
2	became	become	VBD	VBD	_	0	root	_	_
3	irreversible	irreversible	JJ	JJ	_	2	xcomp	_	_
4	,	,	,	,	_	3	punct	_	_
5	however	however	RB	RB	_	3	advmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	upon	upon	IN	IN	_	9	case	_	_
8	simultaneous	simultaneous	JJ	JJ	_	9	amod	_	_
9	treatment	treatment	NN	NN	_	3	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	dexamethasone	dexamethasone	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	transforming	transform	VBG	VBG	_	15	amod	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	factor-beta	factor-beta	NN	NN	_	11	conj	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	TGF-beta	tgf-beta	NN	NN	_	15	appos	_	_
19	1	1	CD	CD	_	18	nummod	_	_
20	)	)	-RRB-	-RRB-	_	18	punct	_	_
21	,	,	,	,	_	9	punct	_	_
22	which	which	WDT	WDT	_	25	nsubj	_	_
23	did	do	VBD	VBD	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	induce	induce	VB	VB	_	9	acl:relcl	_	_
26	differentiation	differentiation	NN	NN	_	25	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	but	but	CC	CC	_	25	cc	_	_
31	caused	cause	VBD	VBD	_	25	conj	_	_
32	growth	growth	NN	NN	_	33	compound	_	_
33	arrest	arrest	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	G0/G1	g0/g1	NN	NN	_	40	compound	_	_
40	phase	phase	NN	NN	_	31	nmod	_	_
41	of	of	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	cycle	cycle	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	ML-9	ml-9	NN	NN	_	8	nsubj	_	_
6	should	should	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	useful	useful	JJ	JJ	_	3	ccomp	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	studying	study	VBG	VBG	_	8	advcl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mechanisms	mechanism	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	monocytic	monocytic	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	hydrophobic	hydrophobic	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Ca2+-modulating	ca2+-modulating	JJ	JJ	_	7	amod	_	_
6	cyclophilin	cyclophilin	NN	NN	_	7	compound	_	_
7	ligand	ligand	NN	NN	_	3	nmod	_	_
8	modulates	modulate	VBZ	VBZ	_	0	root	_	_
9	calcium	calcium	NN	NN	_	11	compound	_	_
10	influx	influx	NN	NN	_	11	compound	_	_
11	signaling	signaling	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Ca2+-modulating	ca2+-modulating	JJ	JJ	_	3	amod	_	_
2	cyclophilin	cyclophilin	NN	NN	_	3	compound	_	_
3	ligand	ligand	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	CAML	caml	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	originally	originally	RB	RB	_	9	advmod	_	_
9	described	describe	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	cyclophilin	cyclophilin	NN	NN	_	14	compound	_	_
13	B-binding	b-binding	JJ	JJ	_	14	amod	_	_
14	protein	protein	NN	NN	_	9	nmod	_	_
15	whose	whose	WP$	WP$	_	16	nmod:poss	_	_
16	overexpression	overexpression	NN	NN	_	20	nsubj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	causes	cause	VBZ	VBZ	_	14	acl:relcl	_	_
21	a	a	DT	DT	_	22	det	_	_
22	rise	rise	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	intracellular	intracellular	JJ	JJ	_	25	amod	_	_
25	calcium	calcium	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	thus	thus	RB	RB	_	28	advmod	_	_
28	activating	activate	VBG	VBG	_	20	advcl	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	28	dobj	_	_
31	responsible	responsible	JJ	JJ	_	30	amod	_	_
32	for	for	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	early	early	JJ	JJ	_	36	amod	_	_
35	immune	immune	JJ	JJ	_	36	amod	_	_
36	response	response	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	reported	report	VBN	VBN	_	15	advcl	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	structure-function	structure-function	JJ	JJ	_	6	amod	_	_
6	analysis	analysis	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CAML	caml	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	Jurkat	jurkat	NN	NN	_	14	compound	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	indicates	indicate	VBZ	VBZ	_	0	root	_	_
16	that	that	IN	IN	_	25	mark	_	_
17	two	two	CD	CD	_	25	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	CAML	caml	NN	NN	_	17	nmod	_	_
20	's	's	POS	POS	_	19	case	_	_
21	putative	putative	JJ	JJ	_	23	amod	_	_
22	membrane-spanning	membrane-spanning	JJ	JJ	_	23	amod	_	_
23	domains	domain	NNS	NNS	_	19	dep	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	necessary	necessary	JJ	JJ	_	15	ccomp	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	sufficient	sufficient	JJ	JJ	_	25	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	modulation	modulation	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	intracellular	intracellular	JJ	JJ	_	33	amod	_	_
33	calcium	calcium	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	hydrophobic	hydrophobic	JJ	JJ	_	7	amod	_	_
6	C-terminal	c-terminal	JJ	JJ	_	7	amod	_	_
7	tail	tail	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CAML	caml	NN	NN	_	7	nmod	_	_
10	forms	form	VBZ	VBZ	_	2	ccomp	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	effector	effector	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	2	punct	_	_
15	thus	thus	RB	RB	_	16	advmod	_	_
16	implicating	implicate	VBG	VBG	_	2	xcomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	N-terminal	n-terminal	JJ	JJ	_	20	amod	_	_
19	hydrophilic	hydrophilic	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	16	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	define	define	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	motif	motif	NN	NN	_	3	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	functions	function	VBZ	VBZ	_	7	acl:relcl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
12	calcium	calcium	NN	NN	_	13	compound	_	_
13	signaling	signaling	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Interactions	interaction	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activator	activator	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	env	env	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	mouse	mouse	NN	NN	_	15	compound	_	_
13	mammary	mammary	JJ	JJ	_	15	amod	_	_
14	tumor	tumor	NN	NN	_	15	compound	_	_
15	virus	virus	NN	NN	_	9	nmod	_	_
16	with	with	IN	IN	_	22	case	_	_
17	activation-dependent	activation-dependent	JJ	JJ	_	22	amod	_	_
18	,	,	,	,	_	22	punct	_	_
19	T	t	NN	NN	_	22	compound	_	_
20	cell-specific	cell-specific	JJ	JJ	_	22	amod	_	_
21	transacting	transact	VBG	VBG	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	1	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	mouse	mouse	NN	NN	_	5	compound	_	_
3	mammary	mammary	JJ	JJ	_	5	amod	_	_
4	tumor	tumor	NN	NN	_	5	compound	_	_
5	virus	virus	NN	NN	_	8	nsubj	_	_
6	env	env	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	5	dep	_	_
8	contains	contain	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activator	activator	NN	NN	_	8	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	META	meta	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	control	control	VB	VB	_	11	acl:relcl	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	25	case	_	_
20	the	the	DT	DT	_	25	det	_	_
21	adjacent	adjacent	JJ	JJ	_	25	amod	_	_
22	long	long	JJ	JJ	_	25	amod	_	_
23	terminal	terminal	JJ	JJ	_	25	amod	_	_
24	repeat	repeat	NN	NN	_	25	compound	_	_
25	region	region	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	META	meta	NN	NN	_	2	nmod	_	_
5	parallels	parallel	VBZ	VBZ	_	0	root	_	_
6	that	that	DT	DT	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	several	several	JJ	JJ	_	10	amod	_	_
9	lymphokine	lymphokine	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	being	be	VBG	VBG	_	13	auxpass	_	_
13	specific	specific	JJ	JJ	_	5	advcl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	dependent	dependent	JJ	JJ	_	13	conj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	inhibited	inhibit	VBN	VBN	_	13	conj	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	immunosuppressive	immunosuppressive	JJ	JJ	_	29	amod	_	_
28	drug	drug	NN	NN	_	29	compound	_	_
29	cyclosporine	cyclosporine	NN	NN	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CsA	csa	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	5	punct	_	_

1	DNase	dnase	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	footprinting	footprinting	NN	NN	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factors	factor	NNS	NNS	_	12	nsubj	_	_
8	from	from	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
12	bound	bind	VBD	VBD	_	4	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	promoter-proximal	promoter-proximal	JJ	JJ	_	15	amod	_	_
15	site	site	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	META(P)	meta(p)	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	promoter-distal	promoter-distal	JJ	JJ	_	22	amod	_	_
22	site	site	NN	NN	_	15	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	META(D+)	meta(d+)	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	15	punct	_	_
26	within	within	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	400-base	400-base	JJ	JJ	_	31	amod	_	_
29	pair	pair	NN	NN	_	31	compound	_	_
30	META	meta	NN	NN	_	31	compound	_	_
31	region	region	NN	NN	_	15	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	12	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	unstimulated	unstimulated	JJ	JJ	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	4	cc	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	from	from	IN	IN	_	9	case	_	_
9	activated	activate	VBN	VBN	_	4	conj	_	_
10	cells	cell	NNS	NNS	_	9	dep	_	_
11	,	,	,	,	_	2	punct	_	_
12	bound	bind	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	site	site	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	META(D-)	meta(d-)	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	adjacent	adjacent	JJ	JJ	_	14	amod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	META(D+)	meta(d+)	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	META(D+)	meta(d+)	NN	NN	_	2	nsubj	_	_
2	directed	direct	VBD	VBD	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	linked	link	VBN	VBN	_	8	amod	_	_
7	luciferase	luciferase	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	gel	gel	NN	NN	_	13	compound	_	_
12	shift	shift	NN	NN	_	13	compound	_	_
13	analysis	analysis	NN	NN	_	14	nsubj	_	_
14	revealed	reveal	VBD	VBD	_	2	conj	_	_
15	binding	binding	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	22	case	_	_
17	inducible	inducible	JJ	JJ	_	22	amod	_	_
18	,	,	,	,	_	22	punct	_	_
19	CsA-sensitive	csa-sensitive	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	15	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	parallel	parallel	NN	NN	_	14	nmod	_	_
26	with	with	IN	IN	_	28	case	_	_
27	transfection	transfection	NN	NN	_	28	compound	_	_
28	results	result	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Authentic	authentic	JJ	JJ	_	2	amod	_	_
2	NFAT	nfat	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	conj	_	_
5	targets	target	NNS	NNS	_	2	dep	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	compete	compete	VB	VB	_	0	root	_	_
9	for	for	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	META(D+)	meta(d+)	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	s	s	NNS	NNS	_	8	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	SV40	sv40	NN	NN	_	4	compound	_	_
3	core	core	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	5	nsubj	_	_
5	competed	compete	VBD	VBD	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	META(D+)	meta(d+)	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	but	but	CC	CC	_	5	cc	_	_
12	META(D+)	meta(d+)	NN	NN	_	13	nsubj	_	_
13	failed	fail	VBD	VBD	_	5	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	compete	compete	VB	VB	_	13	xcomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	complexes	complex	NNS	NNS	_	15	nmod	_	_
19	obtained	obtain	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	SV40	sv40	NN	NN	_	23	compound	_	_
23	probe	probe	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	taken	take	VBN	VBN	_	7	dep	_	_
5	together	together	RB	RB	_	4	advmod	_	_
6	,	,	,	,	_	7	punct	_	_
7	indicate	indicate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	META(D+)	meta(d+)	NN	NN	_	15	nsubj	_	_
10	is	be	VBZ	VBZ	_	15	cop	_	_
11	a	a	DT	DT	_	15	det	_	_
12	novel	novel	JJ	JJ	_	15	amod	_	_
13	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
14	enhancer	enhancer	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	7	ccomp	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	similar	similar	JJ	JJ	_	15	acl:relcl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	cell-type	cell-type	JJ	JJ	_	22	amod	_	_
22	specificity	specificity	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	activation	activation	NN	NN	_	25	compound	_	_
25	dependence	dependence	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	CsA	csa	NN	NN	_	29	compound	_	_
29	sensitivity	sensitivity	NN	NN	_	22	conj	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	NFAT	nfat	NN	NN	_	33	compound	_	_
33	element	element	NN	NN	_	18	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	cop	_	_
4	relevant	relevant	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	MMTV	mmtv	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Mls	mls	NN	NN	_	14	compound	_	_
14	antigens	antigen	NNS	NNS	_	11	nmod	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	11	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lymphomas	lymphoma	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	LIM-Hox	lim-hox	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	hLH-2	hlh-2	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	aberrantly	aberrantly	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	6	dep	_	_
12	in	in	IN	IN	_	15	case	_	_
13	chronic	chronic	JJ	JJ	_	15	amod	_	_
14	myelogenous	myelogenous	JJ	JJ	_	15	amod	_	_
15	leukaemia	leukaemia	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	located	located	JJ	JJ	_	11	conj	_	_
18	on	on	IN	IN	_	19	case	_	_
19	9q33-34.1	9q33-34.1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	isolation	isolation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	LH-2	lh-2	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	12	det	_	_
10	putative	putative	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	7	appos	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	cysteine-rich	cysteine-rich	JJ	JJ	_	16	amod	_	_
16	regions	region	NNS	NNS	_	13	dobj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	LIM	lim	NN	NN	_	19	compound	_	_
19	domains	domain	NNS	NNS	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	a	a	DT	DT	_	28	det	_	_
23	homeobox	homeobox	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	Hox	hox	NN	NN	_	28	compound	_	_
26	)	)	-RRB-	-RRB-	_	28	punct	_	_
27	DNA-binding	dna-binding	JJ	JJ	_	28	amod	_	_
28	domain	domain	NN	NN	_	16	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	hLH-2	hlh-2	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	all	all	DT	DT	_	10	det	_	_
10	cases	case	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	chronic	chronic	JJ	JJ	_	14	amod	_	_
13	myelogenous	myelogenous	JJ	JJ	_	14	amod	_	_
14	leukaemia	leukaemia	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	CML	cml	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	tested	test	VBN	VBN	_	10	acl	_	_
19	,	,	,	,	_	7	punct	_	_
20	regardless	regardless	RB	RB	_	7	advmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	disease	disease	NN	NN	_	23	compound	_	_
23	status	status	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	hLH-2	hlh-2	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	mapped	map	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	chromosome	chromosome	NN	NN	_	6	compound	_	_
6	9Q33-34.1	9q33-34.1	NN	NN	_	3	advcl	_	_
7	,	,	,	,	_	6	punct	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	same	same	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	as	as	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	reciprocal	reciprocal	JJ	JJ	_	15	amod	_	_
15	translocation	translocation	NN	NN	_	11	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	creates	create	VBZ	VBZ	_	15	acl:relcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	BCR-ABL	bcr-abl	NN	NN	_	20	compound	_	_
20	chimera	chimera	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	Philadelphia	philadelphia	NN	NN	_	24	compound	_	_
24	chromosome	chromosome	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Ph	ph	NN	NN	_	24	appos	_	_
27	'	'	''	''	_	26	punct	_	_
28	)	)	-RRB-	-RRB-	_	26	punct	_	_
29	,	,	,	,	_	20	punct	_	_
30	the	the	DT	DT	_	31	det	_	_
31	hallmark	hallmark	NN	NN	_	20	appos	_	_
32	of	of	IN	IN	_	33	case	_	_
33	CML	cml	NN	NN	_	31	nmod	_	_
34	;	;	:	:	_	3	punct	_	_
35	hLH-2	hlh-2	NN	NN	_	37	nsubjpass	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	retained	retain	VBN	VBN	_	3	parataxis	_	_
38	on	on	IN	IN	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	derivative	derivative	JJ	JJ	_	42	amod	_	_
41	9	9	CD	CD	_	42	nummod	_	_
42	chromosome	chromosome	NN	NN	_	37	nmod	_	_
43	and	and	CC	CC	_	37	cc	_	_
44	is	be	VBZ	VBZ	_	46	cop	_	_
45	therefore	therefore	RB	RB	_	46	advmod	_	_
46	centromeric	centromeric	JJ	JJ	_	37	conj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	c-ABL	c-abl	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proximity	proximity	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	hLH-2	hlh-2	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	breakpoint	breakpoint	NN	NN	_	2	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	chromosome	chromosome	NN	NN	_	7	nmod	_	_
10	9	9	CD	CD	_	9	nummod	_	_
11	raises	raise	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	possibility	possibility	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cis-activation	cis-activation	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	t(9;22)(q34;q11)	t(9;22)(q34;q11)	NN	NN	_	19	compound	_	_
19	translocation	translocation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	15	nmod	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	finding	find	VBG	VBG	_	2	acl	_	_
5	hLH-2	hlh-2	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	cases	case	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CML	cml	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	expression	expression	NN	NN	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	observed	observe	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
18	malignancies	malignancy	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	myeloid	myeloid	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	conj	_	_
23	,	,	,	,	_	18	punct	_	_
24	but	but	CC	CC	_	18	cc	_	_
25	not	not	RB	RB	_	28	neg	_	_
26	in	in	IN	IN	_	28	case	_	_
27	primary	primary	JJ	JJ	_	28	amod	_	_
28	cases	case	NNS	NNS	_	18	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	acute	acute	JJ	JJ	_	32	amod	_	_
31	myelogenous	myelogenous	JJ	JJ	_	32	amod	_	_
32	leukaemia	leukaemia	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	hLH-2	hlh-2	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	dep	_	_
7	development	development	NN	NN	_	2	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	progression	progression	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	leukaemia	leukaemia	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	known	know	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	hLH-2	hlh-2	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	prove	prove	VB	VB	_	0	root	_	_
6	useful	useful	JJ	JJ	_	5	xcomp	_	_
7	as	as	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	marker	marker	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CML	cml	NN	NN	_	9	nmod	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	monitoring	monitor	VBG	VBG	_	9	acl	_	_
14	residual	residual	JJ	JJ	_	15	amod	_	_
15	disease	disease	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	type-specific	type-specific	JJ	JJ	_	4	amod	_	_
4	enhancer	enhancer	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	B7.1	b7.1	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	regulated	regulate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	costimulatory	costimulatory	JJ	JJ	_	4	amod	_	_
3	molecule	molecule	NN	NN	_	4	compound	_	_
4	B7.1	b7.1	NN	NN	_	5	nsubj	_	_
5	provides	provide	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	second	second	JJ	JJ	_	8	amod	_	_
8	signal	signal	NN	NN	_	5	dobj	_	_
9	critical	critical	JJ	JJ	_	8	amod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	distribution	distribution	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	this	this	DT	DT	_	7	det	_	_
5	integral	integral	JJ	JJ	_	7	amod	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	restricted	restricted	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	certain	certain	JJ	JJ	_	12	amod	_	_
12	tissues	tissue	NNS	NNS	_	9	nmod	_	_
13	where	where	WRB	WRB	_	19	advmod	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	level	level	NN	NN	_	19	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	expression	expression	NN	NN	_	15	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	modulated	modulate	VBN	VBN	_	12	acl:relcl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	multiple	multiple	JJ	JJ	_	23	amod	_	_
22	exogenous	exogenous	JJ	JJ	_	21	dep	_	_
23	stimuli	stimulus	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	specificity	specificity	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	inducibility	inducibility	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	2	punct	_	_
11	the	the	DT	DT	_	13	det	_	_
12	chromatin	chromatin	NN	NN	_	13	compound	_	_
13	configuration	configuration	NN	NN	_	20	nsubjpass	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	B7.1	b7.1	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	examined	examine	VBN	VBN	_	2	parataxis	_	_
21	in	in	IN	IN	_	23	case	_	_
22	intact	intact	JJ	JJ	_	23	amod	_	_
23	nuclei	nucleus	NNS	NNS	_	20	nmod	_	_
24	from	from	IN	IN	_	27	case	_	_
25	various	various	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	types	type	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	a	a	DT	DT	_	9	det	_	_
5	tissue-specific	tissue-specific	JJ	JJ	_	9	amod	_	_
6	deoxyribonuclease	deoxyribonuclease	NN	NN	_	9	compound	_	_
7	I	i	CD	CD	_	9	nummod	_	_
8	hypersensitive	hypersensitive	JJ	JJ	_	9	amod	_	_
9	site	site	NN	NN	_	2	nmod	_	_
10	approximately	approximately	RB	RB	_	9	advmod	_	_
11	3kb	3kb	JJ	JJ	_	12	amod	_	_
12	upstream	upstream	JJ	JJ	_	10	nmod:npmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	start	start	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	10	nmod	_	_
18	led	lead	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	characterization	characterization	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	cell	cell	NN	NN	_	27	compound	_	_
25	type-specific	type-specific	JJ	JJ	_	27	amod	_	_
26	enhancer	enhancer	NN	NN	_	27	compound	_	_
27	region	region	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	183-bp	183-bp	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	8	nsubj	_	_
4	was	be	VBD	VBD	_	8	cop	_	_
5	both	both	CC	CC	_	8	cc:preconj	_	_
6	cell	cell	NN	NN	_	8	nmod:npmod	_	_
7	type	type	NN	NN	_	8	nmod:npmod	_	_
8	specific	specific	JJ	JJ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	responsive	responsive	JJ	JJ	_	8	conj	_	_
11	to	to	TO	TO	_	14	case	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	stimuli	stimulus	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	lipopolysaccharide	lipopolysaccharide	NN	NN	_	14	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	dibutyryl	dibutyryl	NN	NN	_	19	compound	_	_
19	cAMP	camp	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	known	know	VBN	VBN	_	14	acl	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	regulate	regulate	VB	VB	_	21	xcomp	_	_
24	B7.1	b7.1	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Deletional	deletional	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	site-directed	site-directed	JJ	JJ	_	1	conj	_	_
4	mutagenesis	mutagenesis	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	multiple	multiple	JJ	JJ	_	11	amod	_	_
10	functionally	functionally	RB	RB	_	11	advmod	_	_
11	critical	critical	JJ	JJ	_	13	amod	_	_
12	cis	cis	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	7	nmod	_	_
14	within	within	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	region	region	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	one	one	CD	CD	_	30	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	was	be	VBD	VBD	_	30	cop	_	_
22	a	a	DT	DT	_	30	det	_	_
23	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
24	factor	factor	NN	NN	_	30	compound	_	_
25	(	(	-LRB-	-LRB-	_	30	punct	_	_
26	NF	nf	NN	NN	_	30	compound	_	_
27	)	)	-RRB-	-RRB-	_	30	punct	_	_
28	-kappaB	-kappab	NN	NN	_	30	compound	_	_
29	consensus	consensus	NN	NN	_	30	compound	_	_
30	sequence	sequence	NN	NN	_	13	acl:relcl	_	_
31	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	B7.1-positive	b7.1-positive	JJ	JJ	_	4	amod	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	this	this	DT	DT	_	7	det	_	_
7	element	element	NN	NN	_	8	nsubj	_	_
8	bound	bind	VBD	VBD	_	0	root	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	members	member	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	10	appos	_	_
18	already	already	RB	RB	_	19	advmod	_	_
19	implicated	implicate	VBN	VBN	_	17	acl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	signal	signal	NN	NN	_	23	compound	_	_
22	transduction	transduction	NN	NN	_	23	compound	_	_
23	pathways	pathway	NNS	NNS	_	19	nmod	_	_
24	relevant	relevant	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	B7.1	b7.1	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	description	description	NN	NN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	to	to	TO	TO	_	9	case	_	_
8	our	we	PRP$	PRP$	_	9	nmod:poss	_	_
9	knowledge	knowledge	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	of	of	IN	IN	_	13	case	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	elements	element	NNS	NNS	_	5	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	control	control	VBP	VBP	_	13	acl:relcl	_	_
16	expression	expression	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	gene	gene	NN	NN	_	16	nmod	_	_
20	encoding	encode	VBG	VBG	_	19	acl	_	_
21	a	a	DT	DT	_	24	det	_	_
22	B7	b7	NN	NN	_	24	compound	_	_
23	costimulatory	costimulatory	JJ	JJ	_	24	amod	_	_
24	molecule	molecule	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	5	punct	_	_

1	HLA-DQB1	hla-dqb1	NN	NN	_	2	compound	_	_
2	codon	codon	NN	NN	_	5	nsubj	_	_
3	57	57	CD	CD	_	2	nummod	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	critical	critical	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	peptide	peptide	NN	NN	_	5	nmod	_	_
8	binding	binding	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	recognition	recognition	NN	NN	_	7	conj	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	association	association	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	specific	specific	JJ	JJ	_	6	amod	_	_
5	HLA-DQ	hla-dq	NN	NN	_	6	compound	_	_
6	alleles	allele	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	autoimmunity	autoimmunity	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	correlated	correlate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	discrete	discrete	JJ	JJ	_	13	amod	_	_
13	polymorphisms	polymorphism	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HLA-DQ	hla-dq	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	13	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	localized	localize	VBN	VBN	_	13	acl:relcl	_	_
21	within	within	IN	IN	_	22	case	_	_
22	sites	site	NNS	NNS	_	20	nmod	_	_
23	suitable	suitable	JJ	JJ	_	22	amod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	peptide	peptide	NN	NN	_	26	compound	_	_
26	recognition	recognition	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	polymorphism	polymorphism	NN	NN	_	13	nsubj	_	_
3	at	at	IN	IN	_	4	case	_	_
4	residue	residue	NN	NN	_	2	nmod	_	_
5	57	57	CD	CD	_	4	nummod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	DQB1	dqb1	NN	NN	_	9	compound	_	_
9	polypeptide	polypeptide	NN	NN	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	of	of	IN	IN	_	13	case	_	_
12	particular	particular	JJ	JJ	_	13	amod	_	_
13	interest	interest	NN	NN	_	0	root	_	_
14	since	since	IN	IN	_	17	mark	_	_
15	it	it	PRP	PRP	_	17	nsubj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	play	play	VB	VB	_	13	advcl	_	_
18	a	a	DT	DT	_	21	det	_	_
19	major	major	JJ	JJ	_	21	amod	_	_
20	structural	structural	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	formation	formation	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	salt	salt	NN	NN	_	29	compound	_	_
28	bridge	bridge	NN	NN	_	29	compound	_	_
29	structure	structure	NN	NN	_	24	nmod	_	_
30	at	at	IN	IN	_	32	case	_	_
31	one	one	CD	CD	_	32	nummod	_	_
32	end	end	NN	NN	_	24	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	peptide-binding	peptide-binding	JJ	JJ	_	36	amod	_	_
36	cleft	cleft	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	DQ	dq	NN	NN	_	40	compound	_	_
40	molecules	molecule	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	polymorphism	polymorphism	NN	NN	_	9	nsubj	_	_
3	at	at	IN	IN	_	4	case	_	_
4	residue	residue	NN	NN	_	2	nmod	_	_
5	57	57	CD	CD	_	4	nummod	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	recurrent	recurrent	JJ	JJ	_	9	amod	_	_
9	feature	feature	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HLA-DQ	hla-dq	NN	NN	_	12	compound	_	_
12	evolution	evolution	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	occurring	occur	VBG	VBG	_	9	advcl	_	_
15	in	in	IN	IN	_	19	case	_	_
16	multiple	multiple	JJ	JJ	_	18	amod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	allelic	allelic	JJ	JJ	_	19	amod	_	_
19	families	family	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	implies	imply	VBZ	VBZ	_	9	dep	_	_
23	a	a	DT	DT	_	25	det	_	_
24	functional	functional	JJ	JJ	_	25	amod	_	_
25	selection	selection	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	27	mark	_	_
27	maintaining	maintain	VBG	VBG	_	25	acl	_	_
28	variation	variation	NN	NN	_	27	dobj	_	_
29	at	at	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	position	position	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	class	class	NN	NN	_	36	compound	_	_
35	II	ii	CD	CD	_	36	nummod	_	_
36	molecule	molecule	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	directly	directly	RB	RB	_	3	advmod	_	_
3	tested	test	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	amino	amino	NN	NN	_	7	compound	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	polymorphism	polymorphism	NN	NN	_	3	dobj	_	_
8	at	at	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	site	site	NN	NN	_	7	nmod	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	determinant	determinant	NN	NN	_	3	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	peptide	peptide	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	for	for	IN	IN	_	22	case	_	_
19	antigen-specific	antigen-specific	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	stimulation	stimulation	NN	NN	_	16	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	a	a	DT	DT	_	12	det	_	_
5	single	single	JJ	JJ	_	12	amod	_	_
6	Ala	ala	NN	NN	_	12	compound	_	_
7	--&gt;	--&gt;	TO	TO	_	12	dep	_	_
8	Asp	asp	NN	NN	_	12	compound	_	_
9	amino	amino	NN	NN	_	12	compound	_	_
10	acid	acid	NN	NN	_	12	compound	_	_
11	57	57	CD	CD	_	12	nummod	_	_
12	substitution	substitution	NN	NN	_	17	nsubj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	an	a	DT	DT	_	16	det	_	_
15	HLA-DQ3.2	hla-dq3.2	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	12	nmod	_	_
17	regulated	regulate	VBD	VBD	_	2	ccomp	_	_
18	binding	binding	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	HSV-2	hsv-2	NN	NN	_	23	compound	_	_
22	VP-16-derived	vp-16-derived	JJ	JJ	_	23	amod	_	_
23	peptide	peptide	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	complementary	complementary	JJ	JJ	_	4	amod	_	_
3	single-residue	single-residue	NN	NN	_	4	compound	_	_
4	substitution	substitution	NN	NN	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	peptide	peptide	NN	NN	_	4	nmod	_	_
8	abolished	abolish	VBD	VBD	_	0	root	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	binding	binding	NN	NN	_	8	dobj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	DQ3.2	dq3.2	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	converted	convert	VBD	VBD	_	8	conj	_	_
15	it	it	PRP	PRP	_	14	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	peptide	peptide	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	21	nsubj	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	bind	bind	VB	VB	_	18	acl:relcl	_	_
22	to	to	TO	TO	_	23	case	_	_
23	DQ3.1	dq3.1	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	DQ3.3	dq3.3	NN	NN	_	28	compound	_	_
26	Asp-57-positive	asp-57-positive	JJ	JJ	_	28	amod	_	_
27	MHC	mhc	NN	NN	_	28	compound	_	_
28	molecules	molecule	NNS	NNS	_	23	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	paralleled	parallel	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	specific	specific	JJ	JJ	_	10	amod	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	recognition	recognition	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II-peptide	ii-peptide	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	in	in	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	22	nmod	_	_
19	the	the	DT	DT	_	21	det	_	_
20	substituted	substitute	VBN	VBN	_	21	amod	_	_
21	peptide	peptide	NN	NN	_	22	nsubj	_	_
22	abolished	abolish	VBD	VBD	_	15	acl:relcl	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	reactivity	reactivity	NN	NN	_	22	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	which	which	WDT	WDT	_	29	nsubjpass	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	directed	direct	VBN	VBN	_	25	acl:relcl	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	DQ3.2-peptide	dq3.2-peptide	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	5	punct	_	_
35	whereas	whereas	IN	IN	_	41	mark	_	_
36	the	the	DT	DT	_	40	det	_	_
37	same	same	JJ	JJ	_	40	amod	_	_
38	T	t	NN	NN	_	40	compound	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	clone	clone	NN	NN	_	41	nsubj	_	_
41	recognized	recognize	VBD	VBD	_	5	advcl	_	_
42	the	the	DT	DT	_	44	det	_	_
43	substituted	substitute	VBN	VBN	_	44	amod	_	_
44	peptide	peptide	NN	NN	_	41	dobj	_	_
45	presented	present	VBN	VBN	_	44	acl	_	_
46	by	by	IN	IN	_	47	case	_	_
47	DQ3.3	dq3.3	NN	NN	_	45	nmod	_	_
48	,	,	,	,	_	47	punct	_	_
49	a	a	DT	DT	_	53	det	_	_
50	class	class	NN	NN	_	53	compound	_	_
51	II	ii	CD	CD	_	53	nummod	_	_
52	restriction	restriction	NN	NN	_	53	compound	_	_
53	element	element	NN	NN	_	47	appos	_	_
54	differing	differ	VBG	VBG	_	53	acl	_	_
55	from	from	IN	IN	_	56	case	_	_
56	DQ3.2	dq3.2	NN	NN	_	54	nmod	_	_
57	only	only	RB	RB	_	59	advmod	_	_
58	at	at	IN	IN	_	59	case	_	_
59	residue	residue	NN	NN	_	54	nmod	_	_
60	57	57	CD	CD	_	59	nummod	_	_
61	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	structural	structural	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	functional	functional	JJ	JJ	_	2	conj	_	_
5	complementarity	complementarity	NN	NN	_	14	nsubj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	residue	residue	NN	NN	_	5	nmod	_	_
8	57	57	CD	CD	_	7	nummod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	peptide	peptide	NN	NN	_	13	compound	_	_
13	residue	residue	NN	NN	_	7	conj	_	_
14	identifies	identify	VBZ	VBZ	_	0	root	_	_
15	this	this	DT	DT	_	16	det	_	_
16	interaction	interaction	NN	NN	_	14	dobj	_	_
17	as	as	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	key	key	JJ	JJ	_	21	amod	_	_
20	controlling	control	VBG	VBG	_	21	amod	_	_
21	determinant	determinant	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	restricted	restricted	JJ	JJ	_	24	amod	_	_
24	recognition	recognition	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	HLA-DQ-specific	hla-dq-specific	JJ	JJ	_	28	amod	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	response	response	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	T	t	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	B	b	NN	NN	_	4	conj	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
8	--	--	:	:	_	2	punct	_	_
9	basic	basic	JJ	JJ	_	10	amod	_	_
10	research	research	NN	NN	_	2	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	clinical	clinical	JJ	JJ	_	13	amod	_	_
13	perspectives	perspective	NNS	NNS	_	10	conj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	gastroenterology	gastroenterology	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Tissue	tissue	NN	NN	_	2	nmod:npmod	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	fascinating	fascinating	JJ	JJ	_	14	amod	_	_
13	new	new	JJ	JJ	_	14	amod	_	_
14	field	field	NN	NN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	immunology	immunology	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	summarizes	summarize	VBZ	VBZ	_	0	root	_	_
4	data	datum	NNS	NNS	_	3	dobj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	specific	specific	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	promoters	promoter	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	enhancers	enhancer	NNS	NNS	_	9	conj	_	_
12	by	by	IN	IN	_	15	case	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	trans-acting	trans-acting	JJ	JJ	_	15	amod	_	_
15	factors	factor	NNS	NNS	_	7	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	structural	structural	JJ	JJ	_	3	amod	_	_
3	classes	class	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	described	describe	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	basic	basic	JJ	JJ	_	11	amod	_	_
11	methods	method	NNS	NNS	_	20	nsubjpass	_	_
12	for	for	IN	IN	_	13	case	_	_
13	detection	detection	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	analysis	analysis	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	13	nmod	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	detailed	detail	VBN	VBN	_	8	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	27	advmod	_	_
2	,	,	,	,	_	27	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	important	important	JJ	JJ	_	7	amod	_	_
6	trans-acting	trans-acting	JJ	JJ	_	7	amod	_	_
7	factors	factor	NNS	NNS	_	27	nsubjpass	_	_
8	of	of	IN	IN	_	12	case	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	B	b	NN	NN	_	9	conj	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	20	punct	_	_
14	e.g.	e.g.	FW	FW	_	20	advmod	_	_
15	NF-kB	nf-kb	NN	NN	_	20	compound	_	_
16	,	,	,	,	_	15	punct	_	_
17	NF-AT	nf-at	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	STAT	stat	NN	NN	_	15	conj	_	_
20	families	family	NNS	NNS	_	12	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	functional	functional	JJ	JJ	_	25	amod	_	_
25	importance	importance	NN	NN	_	7	conj	_	_
26	are	be	VBP	VBP	_	27	auxpass	_	_
27	described	describe	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	methods	method	NNS	NNS	_	10	nsubjpass	_	_
3	for	for	IN	IN	_	5	case	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	down-regulation	down-regulation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	that	that	IN	IN	_	14	nsubj	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	relevant	relevant	JJ	JJ	_	10	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	treatment	treatment	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	disease	disease	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	discussed	discuss	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	11	case	_	_
6	regard	regard	NN	NN	_	11	dep	_	_
7	to	to	TO	TO	_	11	case	_	_
8	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
9	potential	potential	JJ	JJ	_	11	amod	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	relevance	relevance	NN	NN	_	4	nmod	_	_
12	for	for	IN	IN	_	13	case	_	_
13	gastroenterology	gastroenterology	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	8	det	_	_
2	novel	novel	JJ	JJ	_	8	amod	_	_
3	interferon	interferon	NN	NN	_	8	compound	_	_
4	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
5	factor	factor	NN	NN	_	8	compound	_	_
6	family	family	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	ICSAT/Pip/LSIRF	icsat/pip/lsirf	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	8	punct	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	negatively	negatively	RB	RB	_	14	advmod	_	_
14	regulates	regulate	VBZ	VBZ	_	8	acl:relcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	interferon-regulated	interferon-regulated	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	cDNA	cdna	NN	NN	_	7	compound	_	_
7	clone	clone	NN	NN	_	3	dobj	_	_
8	encoding	encoding	NN	NN	_	7	dep	_	_
9	interferon	interferon	NN	NN	_	15	compound	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	IFN	ifn	NN	NN	_	15	compound	_	_
12	)	)	-RRB-	-RRB-	_	15	punct	_	_
13	consensus	consensus	NN	NN	_	15	compound	_	_
14	sequence-binding	sequence-binding	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	8	dobj	_	_
16	in	in	IN	IN	_	21	case	_	_
17	adult	adult	JJ	JJ	_	21	amod	_	_
18	T-cell	t-cell	NN	NN	_	21	compound	_	_
19	leukemia	leukemia	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	15	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	ICSAT	icsat	NN	NN	_	15	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	;	;	:	:	_	3	punct	_	_
30	this	this	DT	DT	_	31	det	_	_
31	protein	protein	NN	NN	_	35	nsubj	_	_
32	is	be	VBZ	VBZ	_	35	cop	_	_
33	the	the	DT	DT	_	35	det	_	_
34	human	human	JJ	JJ	_	35	amod	_	_
35	homolog	homolog	NN	NN	_	3	parataxis	_	_
36	of	of	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	recently	recently	RB	RB	_	39	advmod	_	_
39	cloned	clone	VBN	VBN	_	40	amod	_	_
40	Pip/LSIRF	pip/lsirf	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	ICSAT	icsat	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	structurally	structurally	RB	RB	_	6	advmod	_	_
4	most	most	RBS	RBS	_	6	advmod	_	_
5	closely	closely	RB	RB	_	6	advmod	_	_
6	related	related	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	cloned	clone	VBN	VBN	_	11	amod	_	_
11	ICSBP	icsbp	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	member	member	NN	NN	_	11	appos	_	_
15	of	of	IN	IN	_	23	case	_	_
16	the	the	DT	DT	_	23	det	_	_
17	IFN	ifn	NN	NN	_	23	compound	_	_
18	regulatory	regulatory	JJ	JJ	_	23	amod	_	_
19	factor	factor	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	IRF	irf	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	family	family	NN	NN	_	14	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	proteins	protein	NNS	NNS	_	23	nmod	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	binds	bind	VBZ	VBZ	_	14	acl:relcl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	interferon	interferon	NN	NN	_	31	compound	_	_
30	consensus	consensus	NN	NN	_	31	compound	_	_
31	sequences	sequence	NNS	NNS	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ICSs	icss	NNS	NNS	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	found	find	VBN	VBN	_	31	acl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	many	many	JJ	JJ	_	38	amod	_	_
38	promoters	promoter	NNS	NNS	_	35	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	IFN-regulated	ifn-regulated	JJ	JJ	_	42	amod	_	_
42	genes	gene	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	6	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	9	nmod	_	_
4	investigated	investigate	VBN	VBN	_	3	acl	_	_
5	,	,	,	,	_	9	punct	_	_
6	ICSAT	icsat	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	abundantly	abundantly	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	22	case	_	_
11	human	human	JJ	JJ	_	22	amod	_	_
12	T-cell	t-cell	NN	NN	_	22	compound	_	_
13	leukemia	leukemia	NN	NN	_	22	compound	_	_
14	virus	virus	NN	NN	_	22	compound	_	_
15	type	type	NN	NN	_	22	compound	_	_
16	1	1	CD	CD	_	22	nummod	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	HTLV-1	htlv-1	NN	NN	_	22	compound	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	-infected	-infected	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	9	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	When	when	WRB	WRB	_	7	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	HTLV-1	htlv-1	NN	NN	_	5	compound	_	_
4	tax	tax	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	19	advcl	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	phorbol	phorbol	NN	NN	_	12	compound	_	_
10	myristake	myristake	NN	NN	_	12	compound	_	_
11	acetate-A23187	acetate-a23187	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	7	conj	_	_
15	,	,	,	,	_	19	punct	_	_
16	ICSAT	icsat	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	induced	induce	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	Jurkat	jurkat	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	which	which	WDT	WDT	_	27	nsubj	_	_
24	otherwise	otherwise	RB	RB	_	27	advmod	_	_
25	do	do	VBP	VBP	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	express	express	VB	VB	_	22	acl:relcl	_	_
28	ICSAT	icsat	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	19	punct	_	_

1	When	when	WRB	WRB	_	11	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	binding	binding	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	ICSAT	icsat	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	four	four	CD	CD	_	9	nummod	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	ICSs	icss	NNS	NNS	_	3	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	tested	test	VBN	VBN	_	23	advcl	_	_
12	,	,	,	,	_	23	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	relative	relative	JJ	JJ	_	15	amod	_	_
15	differences	difference	NNS	NNS	_	23	nsubjpass	_	_
16	in	in	IN	IN	_	18	case	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	affinities	affinity	NNS	NNS	_	15	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	those	those	DT	DT	_	21	det	_	_
21	ICSs	icss	NNS	NNS	_	18	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	determined	determine	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ICSAT	icsat	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	performed	perform	VBD	VBD	_	2	parataxis	_	_
11	cotransfection	cotransfection	NN	NN	_	12	compound	_	_
12	experiments	experiment	NNS	NNS	_	10	dobj	_	_
13	with	with	IN	IN	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	human	human	JJ	JJ	_	20	amod	_	_
16	embryonal	embryonal	JJ	JJ	_	20	amod	_	_
17	carcinoma	carcinoma	NN	NN	_	20	compound	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	line	line	NN	NN	_	20	compound	_	_
20	N-Tera2	n-tera2	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	ICSAT	icsat	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	possess	possess	VB	VB	_	3	xcomp	_	_
6	repressive	repressive	JJ	JJ	_	7	amod	_	_
7	function	function	NN	NN	_	5	dobj	_	_
8	over	over	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	induced	induce	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	IFN	ifn	NN	NN	_	15	compound	_	_
15	stimulation	stimulation	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	by	by	IN	IN	_	19	case	_	_
18	IRF-1	irf-1	NN	NN	_	19	compound	_	_
19	cotransfection	cotransfection	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	repressive	repressive	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	similar	similar	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	that	that	DT	DT	_	5	nmod	_	_
8	seen	see	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	IRF-2	irf-2	NN	NN	_	8	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	ICSBP	icsbp	NN	NN	_	10	conj	_	_
13	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	ICSAT	icsat	NN	NN	_	8	nsubj	_	_
8	has	have	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	repressive	repressive	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	8	dobj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	that	that	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IRF-2	irf-2	NN	NN	_	14	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	ICSBP	icsbp	NN	NN	_	16	conj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	some	some	DT	DT	_	23	det	_	_
21	IFN-responsive	ifn-responsive	JJ	JJ	_	23	amod	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	constructs	construct	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	``	``	``	``	_	14	punct	_	_
13	differential	differential	JJ	JJ	_	14	amod	_	_
14	repression	repression	NN	NN	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	used	use	VBN	VBN	_	3	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	multiple	multiple	JJ	JJ	_	19	amod	_	_
19	members	member	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	repressor	repressor	NN	NN	_	22	compound	_	_
22	proteins	protein	NNS	NNS	_	19	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	different	different	JJ	JJ	_	26	amod	_	_
25	repressive	repressive	JJ	JJ	_	26	amod	_	_
26	effects	effect	NNS	NNS	_	16	nmod	_	_
27	on	on	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	IFN-responsive	ifn-responsive	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	10	case	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	interferon	interferon	NN	NN	_	10	compound	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	4	cc	_	_
7	gamma	gamma	VB	VB	_	8	dep	_	_
8	interferon	interferon	NN	NN	_	4	conj	_	_
9	signal	signal	NN	NN	_	10	compound	_	_
10	transduction	transduction	NN	NN	_	1	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	esters	ester	NNS	NNS	_	1	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphatase	phosphatase	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	indicated	indicate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	22	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	22	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	oncoproteins	oncoprotein	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	transformation	transformation	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	or	or	CC	CC	_	7	cc	_	_
16	phorbol	phorbol	NN	NN	_	18	compound	_	_
17	ester	ester	NN	NN	_	18	compound	_	_
18	treatment	treatment	NN	NN	_	7	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	18	nmod	_	_
21	can	can	MD	MD	_	22	aux	_	_
22	inhibit	inhibit	VB	VB	_	4	ccomp	_	_
23	alpha/beta	alpha/beta	NN	NN	_	30	compound	_	_
24	interferon	interferon	NN	NN	_	30	compound	_	_
25	(	(	-LRB-	-LRB-	_	30	punct	_	_
26	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	30	compound	_	_
27	)	)	-RRB-	-RRB-	_	30	punct	_	_
28	-induced	-induced	JJ	JJ	_	30	amod	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	22	dobj	_	_
31	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	14	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	10	nmod	_	_
5	these	these	DT	DT	_	6	det	_	_
6	promoters	promoter	NNS	NNS	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	6	nmod	_	_
10	exert	exert	VB	VB	_	2	acl:relcl	_	_
11	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
12	inhibitory	inhibitory	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	10	dobj	_	_
14	vary	vary	VBP	VBP	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	in	in	IN	IN	_	19	case	_	_
18	most	most	JJS	JJS	_	19	amod	_	_
19	instances	instance	NNS	NNS	_	21	nmod	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	involve	involve	VBP	VBP	_	14	conj	_	_
22	a	a	DT	DT	_	23	det	_	_
23	disruption	disruption	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	IFN-alpha/beta-induced	ifn-alpha/beta-induced	JJ	JJ	_	29	amod	_	_
27	transcription	transcription	NN	NN	_	29	compound	_	_
28	complex	complex	NN	NN	_	29	compound	_	_
29	ISGF3	isgf3	NN	NN	_	23	nmod	_	_
30	such	such	JJ	JJ	_	46	dep	_	_
31	that	that	IN	IN	_	46	mark	_	_
32	the	the	DT	DT	_	34	det	_	_
33	DNA-binding	dna-binding	JJ	JJ	_	34	amod	_	_
34	component	component	NN	NN	_	46	nsubj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	this	this	DT	DT	_	37	det	_	_
37	complex	complex	NN	NN	_	34	nmod	_	_
38	(	(	-LRB-	-LRB-	_	42	punct	_	_
39	the	the	DT	DT	_	42	det	_	_
40	48-kDa	48-kda	JJ	JJ	_	42	amod	_	_
41	ISGF3gamma	isgf3gamma	NN	NN	_	42	compound	_	_
42	protein	protein	NN	NN	_	37	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	does	do	VBZ	VBZ	_	46	aux	_	_
45	not	not	RB	RB	_	46	neg	_	_
46	bind	bind	VB	VB	_	21	dep	_	_
47	to	to	TO	TO	_	51	case	_	_
48	the	the	DT	DT	_	51	det	_	_
49	interferon-stimulated	interferon-stimulated	JJ	JJ	_	51	amod	_	_
50	response	response	NN	NN	_	51	compound	_	_
51	element	element	NN	NN	_	46	nmod	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	ISRE	isre	NN	NN	_	51	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	6	dep	_	_
8	phorbol	phorbol	NN	NN	_	10	compound	_	_
9	ester	ester	NN	NN	_	10	compound	_	_
10	treatment	treatment	NN	NN	_	17	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
16	dramatically	dramatically	RB	RB	_	17	advmod	_	_
17	inhibits	inhibit	VBZ	VBZ	_	7	dep	_	_
18	activation	activation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	IFN-alpha/B-stimulated	ifn-alpha/b-stimulated	JJ	JJ	_	23	amod	_	_
21	early	early	JJ	JJ	_	23	amod	_	_
22	response	response	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	18	nmod	_	_
24	but	but	CC	CC	_	17	cc	_	_
25	by	by	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	mechanism	mechanism	NN	NN	_	17	conj	_	_
28	which	which	WDT	WDT	_	31	nsubj	_	_
29	does	do	VBZ	VBZ	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	involve	involve	VB	VB	_	27	acl:relcl	_	_
32	abrogation	abrogation	NN	NN	_	31	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	ISRE	isre	NN	NN	_	36	compound	_	_
36	binding	binding	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	ISGF3gamma	isgf3gamma	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	Phorbol	phorbol	NN	NN	_	3	compound	_	_
2	ester	ester	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	IFN	ifn	NN	NN	_	10	compound	_	_
8	alpha-stimulated	alpha-stimulated	JJ	JJ	_	10	amod	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	Stat1alpha	stat1alpha	NN	NN	_	14	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	Stat2	stat2	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	Stat3	stat3	NN	NN	_	15	conj	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	kinase	kinase	NN	NN	_	14	conj	_	_
26	Tyk2	tyk2	NN	NN	_	25	dep	_	_
27	but	but	CC	CC	_	6	cc	_	_
28	had	have	VBD	VBD	_	6	conj	_	_
29	no	no	DT	DT	_	30	neg	_	_
30	effect	effect	NN	NN	_	28	dobj	_	_
31	on	on	IN	IN	_	33	case	_	_
32	IFN-gamma	ifn-gamma	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	Stat1alpha	stat1alpha	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	IFNalpha-stimulated	ifnalpha-stimulated	JJ	JJ	_	3	amod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Jak1	jak1	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	subunit	subunit	NN	NN	_	3	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IFN-alpha	ifn-alpha	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	unaffected	unaffected	JJ	JJ	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	phorbol	phorbol	NN	NN	_	19	compound	_	_
18	12-myristate	12-myristate	NN	NN	_	19	compound	_	_
19	13-acetate	13-acetate	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	15	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	PMA	pma	NN	NN	_	4	nsubj	_	_
4	caused	cause	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	dephosphorylation	dephosphorylation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Tyk2	tyk2	NN	NN	_	6	nmod	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Jak1	jak1	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	activated	activate	VBN	VBN	_	12	acl:relcl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	IFN	ifn	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	vanadate	vanadate	NN	NN	_	1	nmod	_	_
6	prevented	prevent	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	PMA	pma	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	regard	regard	NN	NN	_	6	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	PMA-induced	pma-induced	JJ	JJ	_	16	amod	_	_
15	Tyk2	tyk2	NN	NN	_	16	compound	_	_
16	dephosphorylation	dephosphorylation	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	PMA	pma	NN	NN	_	6	nsubj	_	_
6	exerts	exert	VBZ	VBZ	_	3	ccomp	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphatase	phosphatase	NN	NN	_	11	nmod	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	selectively	selectively	RB	RB	_	18	advmod	_	_
18	regulates	regulate	VBZ	VBZ	_	15	acl:relcl	_	_
19	Tyk2	tyk2	NN	NN	_	18	dobj	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	19	cc	_	_
22	Jak1	jak1	NN	NN	_	19	conj	_	_
23	activity	activity	NN	NN	_	19	dep	_	_
24	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	RNA	rna	NN	NN	_	7	compound	_	_
5	polymerase	polymerase	NN	NN	_	7	compound	_	_
6	III-dependent	iii-dependent	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	2	nmod	_	_
8	by	by	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	human	human	JJ	JJ	_	17	amod	_	_
11	T-cell	t-cell	NN	NN	_	17	compound	_	_
12	leukemia	leukemia	NN	NN	_	17	compound	_	_
13	virus	virus	NN	NN	_	17	compound	_	_
14	type	type	NN	NN	_	17	compound	_	_
15	1	1	CD	CD	_	17	nummod	_	_
16	tax	tax	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	2	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	T-cell	t-cell	NN	NN	_	7	compound	_	_
4	leukemia	leukemia	NN	NN	_	7	compound	_	_
5	virus-encoded	virus-encoded	JJ	JJ	_	7	amod	_	_
6	tax	tax	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	activator	activator	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	many	many	JJ	JJ	_	14	amod	_	_
14	viral	viral	JJ	JJ	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cellular	cellular	JJ	JJ	_	14	conj	_	_
17	genes	gene	NNS	NNS	_	14	dep	_	_
18	transcribed	transcribe	VBN	VBN	_	14	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	RNA	rna	NN	NN	_	21	compound	_	_
21	polymerase	polymerase	NN	NN	_	18	nmod	_	_
22	II	ii	CD	CD	_	21	nummod	_	_
23	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	chromatin	chromatin	NN	NN	_	20	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	extracts	extract	NNS	NNS	_	5	conj	_	_
9	derived	derive	VBN	VBN	_	5	acl	_	_
10	from	from	IN	IN	_	19	case	_	_
11	human	human	JJ	JJ	_	19	amod	_	_
12	T-cell	t-cell	NN	NN	_	19	compound	_	_
13	leukemia	leukemia	NN	NN	_	19	compound	_	_
14	virus	virus	NN	NN	_	19	compound	_	_
15	type	type	NN	NN	_	19	compound	_	_
16	1-infected	1-infected	JJ	JJ	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
20	support	support	VBP	VBP	_	2	ccomp	_	_
21	higher	higher	JJR	JJR	_	22	amod	_	_
22	levels	level	NNS	NNS	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	5S	5s	NN	NN	_	25	compound	_	_
25	rRNA	rrna	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	tRNA	trna	NN	NN	_	25	conj	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	25	dep	_	_
30	than	than	IN	IN	_	31	mark	_	_
31	chromatin	chromatin	NN	NN	_	22	dep	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	extracts	extract	NNS	NNS	_	31	conj	_	_
34	from	from	IN	IN	_	37	case	_	_
35	uninfected	uninfected	JJ	JJ	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	viral	viral	JJ	JJ	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	Tax	tax	NN	NN	_	7	nsubj	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	likely	likely	JJ	JJ	_	7	amod	_	_
7	responsible	responsible	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	11	case	_	_
9	this	this	DT	DT	_	11	det	_	_
10	higher	higher	JJR	JJR	_	11	amod	_	_
11	level	level	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	as	as	IN	IN	_	22	mark	_	_
19	purified	purify	VBN	VBN	_	20	amod	_	_
20	Tax	tax	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	found	find	VBN	VBN	_	7	advcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	stimulate	stimulate	VB	VB	_	22	xcomp	_	_
25	both	both	DT	DT	_	26	det	_	_
26	genes	gene	NNS	NNS	_	24	dobj	_	_
27	when	when	WRB	WRB	_	28	advmod	_	_
28	added	add	VBN	VBN	_	24	dep	_	_
29	to	to	TO	TO	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	uninfected	uninfected	JJ	JJ	_	33	amod	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	extract	extract	NN	NN	_	28	nmod	_	_
34	or	or	CC	CC	_	28	cc	_	_
35	in	in	IN	IN	_	37	case	_	_
36	reconstituted	reconstitute	VBN	VBN	_	37	amod	_	_
37	systems	system	NNS	NNS	_	28	conj	_	_
38	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	limiting-component	limiting-component	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	4	conj	_	_
9	identified	identify	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	15	det	_	_
11	class	class	NN	NN	_	15	compound	_	_
12	III	iii	CD	CD	_	15	nummod	_	_
13	gene	gene	NN	NN	_	15	compound	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	9	dobj	_	_
16	TFIIIB	tfiiib	NN	NN	_	15	dep	_	_
17	as	as	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	principle	principle	NN	NN	_	20	compound	_	_
20	target	target	NN	NN	_	9	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	Tax	tax	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	find	find	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	Tax	tax	NN	NN	_	7	nsubj	_	_
7	increases	increase	VBZ	VBZ	_	4	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	effective	effective	JJ	JJ	_	10	amod	_	_
10	concentration	concentration	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	active	active	JJ	JJ	_	14	amod	_	_
13	TFIIIB	tfiiib	NN	NN	_	14	compound	_	_
14	molecules	molecule	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Tax	tax	NN	NN	_	6	nsubj	_	_
6	stimulates	stimulate	VBZ	VBZ	_	3	ccomp	_	_
7	RNA	rna	NN	NN	_	10	compound	_	_
8	polymerase	polymerase	NN	NN	_	10	compound	_	_
9	III-dependent	iii-dependent	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	6	dobj	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	accelerating	accelerate	VBG	VBG	_	6	advcl	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	rate	rate	NN	NN	_	13	dobj	_	_
16	and/or	and/or	CC	CC	_	15	cc	_	_
17	extent	extent	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	initiation	initiation	NN	NN	_	21	compound	_	_
21	complex	complex	NN	NN	_	22	compound	_	_
22	assembly	assembly	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	p105	p105	NN	NN	_	4	compound	_	_
4	processing	processing	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	transiently	transiently	RB	RB	_	11	advmod	_	_
10	transfected	transfect	VBN	VBN	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Regulation	regulation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	5	dep	_	_
7	involves	involve	VBZ	VBZ	_	0	root	_	_
8	proteasome-mediated	proteasome-mediated	JJ	JJ	_	9	amod	_	_
9	processing	processing	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	NF-kappaB1	nf-kappab1	NN	NN	_	15	compound	_	_
13	p105	p105	NN	NN	_	15	compound	_	_
14	precursor	precursor	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	generates	generate	VBZ	VBZ	_	9	acl:relcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p50	p50	NN	NN	_	21	compound	_	_
21	subunit	subunit	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	processing	processing	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p105	p105	NN	NN	_	2	nmod	_	_
5	occurs	occur	VBZ	VBZ	_	0	root	_	_
6	constitutively	constitutively	RB	RB	_	5	advmod	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vivo	vivo	FW	FW	_	5	advmod	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	can	can	MD	MD	_	13	aux	_	_
11	be	be	VB	VB	_	13	auxpass	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	enhanced	enhance	VBN	VBN	_	5	conj	_	_
14	by	by	IN	IN	_	18	case	_	_
15	various	various	JJ	JJ	_	18	amod	_	_
16	cellular	cellular	JJ	JJ	_	18	amod	_	_
17	activation	activation	NN	NN	_	18	compound	_	_
18	agents	agent	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	although	although	IN	IN	_	28	mark	_	_
21	the	the	DT	DT	_	24	det	_	_
22	underlying	underlying	JJ	JJ	_	23	amod	_	_
23	regulatory	regulatory	JJ	JJ	_	24	amod	_	_
24	mechanism	mechanism	NN	NN	_	28	nsubj	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	not	not	RB	RB	_	27	dep	_	_
27	yet	yet	RB	RB	_	28	advmod	_	_
28	clear	clear	JJ	JJ	_	5	advcl	_	_
29	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	signal-mediated	signal-mediated	JJ	JJ	_	10	amod	_	_
10	induction	induction	NN	NN	_	19	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	p105	p105	NN	NN	_	13	compound	_	_
13	processing	processing	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	associated	associate	VBN	VBN	_	7	ccomp	_	_
20	with	with	IN	IN	_	23	case	_	_
21	de	de	FW	FW	_	23	amod	_	_
22	novo	novo	FW	FW	_	21	dep	_	_
23	synthesis	synthesis	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	this	this	DT	DT	_	27	det	_	_
26	precursor	precursor	JJ	JJ	_	27	amod	_	_
27	protein	protein	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	8	nsubj	_	_
4	performed	perform	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	COS7	cos7	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	the	the	DT	DT	_	14	det	_	_
11	newly	newly	RB	RB	_	12	advmod	_	_
12	synthesized	synthesize	VBN	VBN	_	14	amod	_	_
13	p105	p105	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	15	nsubj	_	_
15	appears	appear	VBZ	VBZ	_	8	ccomp	_	_
16	to	to	TO	TO	_	20	mark	_	_
17	be	be	VB	VB	_	20	auxpass	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	rapidly	rapidly	RB	RB	_	20	advmod	_	_
20	processed	process	VBN	VBN	_	15	xcomp	_	_
21	compared	compare	VBN	VBN	_	25	case	_	_
22	to	to	TO	TO	_	25	case	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	accumulated	accumulate	VBN	VBN	_	25	amod	_	_
25	form	form	NN	NN	_	20	advcl	_	_
26	that	that	WDT	WDT	_	29	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	already	already	RB	RB	_	29	advmod	_	_
29	associated	associate	VBN	VBN	_	25	acl:relcl	_	_
30	with	with	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	processed	process	VBN	VBN	_	33	amod	_	_
33	product	product	NN	NN	_	29	nmod	_	_
34	p50	p50	NN	NN	_	33	dep	_	_
35	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	processing	processing	NN	NN	_	5	compound	_	_
5	rate	rate	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p105	p105	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	co-transfected	co-transfect	VBN	VBN	_	12	acl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	p50	p50	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	subunits	subunit	NNS	NNS	_	15	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	22	case	_	_
22	RelA	rela	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	c-Rel	c-rel	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	19	punct	_	_
26	that	that	WDT	WDT	_	28	nsubj	_	_
27	physically	physically	RB	RB	_	28	advmod	_	_
28	interact	interact	VBP	VBP	_	19	acl:relcl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	p105	p105	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	processing	processing	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p105	p105	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	subject	subject	JJ	JJ	_	3	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	negative	negative	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	various	various	JJ	JJ	_	18	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	subunits	subunit	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RBR	RBR	_	3	advmod	_	_
3	demonstrate	demonstrate	VB	VB	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	p105	p105	NN	NN	_	6	nsubj	_	_
6	undergoes	undergo	VBZ	VBZ	_	3	ccomp	_	_
7	degradation	degradation	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	degradation	degradation	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p105	p105	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	coupled	couple	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	generation	generation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	p50	p50	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	processing	processing	NN	NN	_	16	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	inducible	inducible	JJ	JJ	_	11	amod	_	_
11	degradation	degradation	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p105	p105	NN	NN	_	8	nmod	_	_
14	are	be	VBP	VBP	_	16	auxpass	_	_
15	differentially	differentially	RB	RB	_	16	advmod	_	_
16	regulated	regulate	VBN	VBN	_	5	ccomp	_	_
17	.	.	.	.	_	5	punct	_	_

1	BCL-6	bcl-6	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	during	during	IN	IN	_	5	case	_	_
4	B-cell	b-cell	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	Translocations	translocation	NNS	NNS	_	7	nsubj	_	_
2	involving	involve	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	BCL-6	bcl-6	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	2	dobj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	common	common	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	diffuse	diffuse	JJ	JJ	_	13	amod	_	_
11	large	large	JJ	JJ	_	10	dep	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	subtype	subtype	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	non-Hodgkin	non-hodgkin	JJ	JJ	_	17	nmod:poss	_	_
16	's	's	POS	POS	_	15	case	_	_
17	lymphoma	lymphoma	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Invariably	invariably	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	BCL-6	bcl-6	NN	NN	_	6	compound	_	_
5	coding	coding	NN	NN	_	6	compound	_	_
6	region	region	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	intact	intact	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	8	cc	_	_
11	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
12	5'	5'	JJ	JJ	_	14	amod	_	_
13	untranslated	untranslated	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	replaced	replace	VBN	VBN	_	8	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	sequences	sequence	NNS	NNS	_	16	nmod	_	_
19	from	from	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	translocation	translocation	NN	NN	_	22	compound	_	_
22	partner	partner	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	shows	show	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	BCL-6	bcl-6	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
12	during	during	IN	IN	_	14	case	_	_
13	mitogenic	mitogenic	JJ	JJ	_	14	amod	_	_
14	stimulation	stimulation	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Resting	rest	VBG	VBG	_	2	amod	_	_
2	B	b	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	T	t	NN	NN	_	2	conj	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	dep	_	_
6	contain	contain	VBP	VBP	_	0	root	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	BCL-6	bcl-6	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Stimulation	stimulation	NN	NN	_	24	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	mouse	mouse	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	anti-IgM	anti-igm	JJ	JJ	_	1	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	IgD	igd	NN	NN	_	7	conj	_	_
10	antibodies	antibody	NNS	NNS	_	7	dep	_	_
11	,	,	,	,	_	7	punct	_	_
12	bacterial	bacterial	JJ	JJ	_	13	amod	_	_
13	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	appos	_	_
14	,	,	,	,	_	13	punct	_	_
15	phorbol	phorbol	NN	NN	_	17	compound	_	_
16	12-myristate	12-myristate	NN	NN	_	17	compound	_	_
17	13-acetate	13-acetate	NN	NN	_	13	conj	_	_
18	plus	plus	CC	CC	_	17	cc	_	_
19	ionomycin	ionomycin	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	or	or	CC	CC	_	13	cc	_	_
22	CD40	cd40	NN	NN	_	23	compound	_	_
23	ligand	ligand	NN	NN	_	13	conj	_	_
24	led	lead	VBD	VBD	_	0	root	_	_
25	to	to	TO	TO	_	30	case	_	_
26	a	a	DT	DT	_	30	det	_	_
27	five-fold	five-fold	JJ	JJ	_	29	amod	_	_
28	to	to	TO	TO	_	29	dep	_	_
29	35-fold	35-fold	JJ	JJ	_	30	amod	_	_
30	decrease	decrease	NN	NN	_	24	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	BCL-6	bcl-6	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	34	compound	_	_
34	levels	level	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	24	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	downregulation	downregulation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	BCL-6	bcl-6	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	seen	see	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	stimulated	stimulate	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	Staphylococcus	staphylococcus	FW	FW	_	15	compound	_	_
15	aureus	aureus	FW	FW	_	12	nmod	_	_
16	plus	plus	CC	CC	_	15	cc	_	_
17	interleukin-2	interleukin-2	NN	NN	_	15	conj	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	anti-IgM	anti-igm	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	17	conj	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	in	in	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	11	conj	_	_
26	stimulated	stimulate	VBN	VBN	_	25	acl	_	_
27	with	with	IN	IN	_	28	case	_	_
28	phytohemagglutinin	phytohemagglutinin	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	BCL-6	bcl-6	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	4	nsubj	_	_
4	began	begin	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	decrease	decrease	VB	VB	_	4	xcomp	_	_
7	8	8	CD	CD	_	9	compound	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	16	16	CD	CD	_	10	nummod	_	_
10	hours	hour	NNS	NNS	_	6	nmod	_	_
11	after	after	IN	IN	_	10	case	_	_
12	stimulation	stimulation	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	4	punct	_	_
14	before	before	IN	IN	_	16	mark	_	_
15	cells	cell	NNS	NNS	_	16	nsubj	_	_
16	entered	enter	VBD	VBD	_	4	advcl	_	_
17	S	s	NN	NN	_	18	compound	_	_
18	phase	phase	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	10	mark	_	_
2	polyclonal	polyclonal	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	3	advmod	_	_
9	invariably	invariably	RB	RB	_	10	advmod	_	_
10	decreased	decrease	VBD	VBD	_	22	advcl	_	_
11	BCL-6	bcl-6	NN	NN	_	13	compound	_	_
12	MRNA	mrna	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	22	punct	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	22	nsubj	_	_
18	from	from	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	germinal	germinal	JJ	JJ	_	21	amod	_	_
21	centers	center	NNS	NNS	_	17	nmod	_	_
22	expressed	express	VBD	VBD	_	0	root	_	_
23	BCL-6	bcl-6	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	22	dobj	_	_
25	at	at	IN	IN	_	26	case	_	_
26	levels	level	NNS	NNS	_	22	nmod	_	_
27	comparable	comparable	JJ	JJ	_	26	amod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	levels	level	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	resting	rest	VBG	VBG	_	34	amod	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	22	punct	_	_

1	Despite	despite	IN	IN	_	5	case	_	_
2	these	these	DT	DT	_	5	det	_	_
3	similar	similar	JJ	JJ	_	5	amod	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	14	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	BCL-6	bcl-6	NN	NN	_	9	compound	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	14	nsubj	_	_
10	was	be	VBD	VBD	_	14	cop	_	_
11	threefold	threefold	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	34-fold	34-fold	RB	RB	_	14	nmod:npmod	_	_
14	higher	higher	JJR	JJR	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	germinal	germinal	JJ	JJ	_	19	amod	_	_
17	center	center	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	than	than	IN	IN	_	24	case	_	_
21	in	in	IN	IN	_	24	case	_	_
22	resting	rest	VBG	VBG	_	24	amod	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	14	nmod	_	_
25	,	,	,	,	_	14	punct	_	_
26	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	BCL-6	bcl-6	NN	NN	_	30	compound	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	levels	level	NNS	NNS	_	32	nsubjpass	_	_
31	are	be	VBP	VBP	_	32	auxpass	_	_
32	controlled	control	VBN	VBN	_	26	ccomp	_	_
33	by	by	IN	IN	_	34	case	_	_
34	translational	translational	JJ	JJ	_	32	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	posttranslational	posttranslational	JJ	JJ	_	34	conj	_	_
37	mechanisms	mechanism	NNS	NNS	_	34	dep	_	_
38	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	germinal	germinal	JJ	JJ	_	8	amod	_	_
7	center	center	NN	NN	_	8	compound	_	_
8	reaction	reaction	NN	NN	_	9	nsubj	_	_
9	provides	provide	VBZ	VBZ	_	3	ccomp	_	_
10	unique	unique	JJ	JJ	_	12	amod	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	signals	signal	NNS	NNS	_	9	dobj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	allow	allow	VBP	VBP	_	3	dep	_	_
18	for	for	IN	IN	_	23	case	_	_
19	continued	continued	JJ	JJ	_	23	amod	_	_
20	,	,	,	,	_	19	punct	_	_
21	high-level	high-level	JJ	JJ	_	19	dep	_	_
22	BCL-6	bcl-6	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Modulation	modulation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	beta-chain	beta-chain	NN	NN	_	4	nmod	_	_
10	controls	control	VBZ	VBZ	_	0	root	_	_
11	responsiveness	responsiveness	NN	NN	_	10	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	IFN-gamma	ifn-gamma	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	nsubj	_	_
2	has	have	VBZ	VBZ	_	0	root	_	_
3	potent	potent	JJ	JJ	_	7	amod	_	_
4	antiproliferative	antiproliferative	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	apoptotic	apoptotic	JJ	JJ	_	4	conj	_	_
7	effects	effect	NNS	NNS	_	2	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	important	important	JJ	JJ	_	2	dep	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	determining	determine	VBG	VBG	_	13	advcl	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cell	cell	NN	NN	_	15	dobj	_	_
18	development	development	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	polarized	polarize	VBN	VBN	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	any	any	DT	DT	_	4	det	_	_
4	event	event	NN	NN	_	17	nsubj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	enables	enable	VBZ	VBZ	_	4	acl:relcl	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	6	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	become	become	VB	VB	_	6	xcomp	_	_
11	less	less	RBR	RBR	_	12	advmod	_	_
12	responsive	responsive	JJ	JJ	_	10	xcomp	_	_
13	to	to	TO	TO	_	14	case	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	nmod	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	potentially	potentially	RB	RB	_	17	advmod	_	_
17	alter	alter	VB	VB	_	0	root	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	responsiveness	responsiveness	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	Ag	ag	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	work	work	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	24	mark	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	24	nsubj	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	stimulated	stimulate	VBN	VBN	_	12	acl:relcl	_	_
16	through	through	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	TCR	tcr	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	expanded	expand	VBN	VBN	_	15	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	IL-2	il-2	NN	NN	_	20	nmod	_	_
23	are	be	VBP	VBP	_	24	cop	_	_
24	unresponsive	unresponsive	JJ	JJ	_	6	ccomp	_	_
25	to	to	TO	TO	_	26	case	_	_
26	IFN-gamma	ifn-gamma	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	24	punct	_	_
28	as	as	IN	IN	_	29	mark	_	_
29	determined	determine	VBN	VBN	_	24	advcl	_	_
30	by	by	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	lack	lack	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	activation	activation	NN	NN	_	32	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	jak	jak	NN	NN	_	37	compound	_	_
37	kinases	kinase	NNS	NNS	_	34	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	the	the	DT	DT	_	41	det	_	_
40	transcription	transcription	NN	NN	_	41	compound	_	_
41	factor	factor	NN	NN	_	37	conj	_	_
42	,	,	,	,	_	41	punct	_	_
43	STAT1(alpha)	stat1(alpha)	NN	NN	_	41	appos	_	_
44	,	,	,	,	_	34	punct	_	_
45	a	a	DT	DT	_	47	det	_	_
46	signal	signal	NN	NN	_	47	compound	_	_
47	transducer	transducer	NN	NN	_	34	conj	_	_
48	and	and	CC	CC	_	34	cc	_	_
49	activator	activator	NN	NN	_	34	conj	_	_
50	of	of	IN	IN	_	51	case	_	_
51	transcription	transcription	NN	NN	_	49	nmod	_	_
52	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	nonresponsiveness	nonresponsiveness	NN	NN	_	3	nsubj	_	_
3	occurs	occur	VBZ	VBZ	_	0	root	_	_
4	because	because	IN	IN	_	7	case	_	_
5	of	of	IN	IN	_	4	mwe	_	_
6	a	a	DT	DT	_	7	det	_	_
7	lack	lack	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	expression	expression	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	beta-chain	beta-chain	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	accessory	accessory	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IFN-gamma	ifn-gamma	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	3	punct	_	_
22	while	while	IN	IN	_	27	mark	_	_
23	at	at	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	dep	_	_
25	same	same	JJ	JJ	_	26	dep	_	_
26	time	time	NN	NN	_	27	advcl	_	_
27	maintaining	maintain	VBG	VBG	_	3	advcl	_	_
28	IFN-gamma	ifn-gamma	NN	NN	_	31	compound	_	_
29	receptor	receptor	NN	NN	_	31	compound	_	_
30	alpha-chain	alpha-chain	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	27	dobj	_	_
32	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	beta-chain	beta-chain	NN	NN	_	1	nmod	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	restored	restore	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	secondary	secondary	JJ	JJ	_	11	amod	_	_
10	TCR	tcr	NN	NN	_	11	compound	_	_
11	ligation	ligation	NN	NN	_	7	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	PMA	pma	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	7	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	blasts	blast	NNS	NNS	_	9	nsubj	_	_
4	treated	treat	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PMA	pma	NNS	NNS	_	4	nmod	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	now	now	RB	RB	_	9	advmod	_	_
9	responsive	responsive	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	IFN-gamma	ifn-gamma	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	When	when	WRB	WRB	_	3	advmod	_	_
2	freshly	freshly	RB	RB	_	3	advmod	_	_
3	isolated	isolate	VBN	VBN	_	15	advcl	_	_
4	,	,	,	,	_	15	punct	_	_
5	highly	highly	RB	RB	_	6	advmod	_	_
6	enriched	enrich	VBN	VBN	_	13	amod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	&gt;	&gt;	JJR	JJR	_	9	advmod	_	_
9	98	98	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	6	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	examined	examine	VBN	VBN	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	18	compound	_	_
18	responsiveness	responsiveness	NN	NN	_	15	nmod	_	_
19	;	;	:	:	_	15	punct	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	23	nsubj	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	respond	respond	VB	VB	_	15	parataxis	_	_
24	to	to	TO	TO	_	25	case	_	_
25	IFN-gamma	ifn-gamma	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	express	express	VB	VB	_	23	conj	_	_
28	beta-chain	beta-chain	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	23	punct	_	_

1	Therefore	therefore	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	as	as	IN	IN	_	6	mark	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	progress	progress	VBP	VBP	_	25	dep	_	_
7	from	from	IN	IN	_	10	case	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	TCR	tcr	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	through	through	IN	IN	_	13	case	_	_
12	IL-2-dependent	il-2-dependent	JJ	JJ	_	13	amod	_	_
13	proliferation	proliferation	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	followed	follow	VBN	VBN	_	6	dep	_	_
16	by	by	IN	IN	_	19	case	_	_
17	secondary	secondary	JJ	JJ	_	19	amod	_	_
18	TCR	tcr	NN	NN	_	19	compound	_	_
19	stimulation	stimulation	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	25	punct	_	_
21	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
22	responsiveness	responsiveness	NN	NN	_	25	nsubj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	IFN-gamma	ifn-gamma	NN	NN	_	22	nmod	_	_
25	varies	vary	VBZ	VBZ	_	0	root	_	_
26	,	,	,	,	_	25	punct	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	this	this	DT	DT	_	30	nsubj	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	affect	affect	VB	VB	_	25	conj	_	_
31	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
32	ability	ability	NN	NN	_	30	dobj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	participate	participate	VB	VB	_	32	acl	_	_
35	in	in	IN	IN	_	39	case	_	_
36	an	a	DT	DT	_	39	det	_	_
37	ongoing	ongoing	JJ	JJ	_	39	amod	_	_
38	immune	immune	JJ	JJ	_	39	amod	_	_
39	response	response	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	25	punct	_	_

1	Opposing	opposing	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	rate	rate	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	neutrophilic	neutrophilic	JJ	JJ	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	eosinophilic	eosinophilic	JJ	JJ	_	11	conj	_	_
14	granulocytes	granulocyte	NNS	NNS	_	11	dep	_	_
15	.	.	.	.	_	2	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	10	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	neutrophils	neutrophil	NNS	NNS	_	1	conj	_	_
4	are	be	VBP	VBP	_	10	cop	_	_
5	closely	closely	RB	RB	_	6	advmod	_	_
6	related	related	JJ	JJ	_	10	amod	_	_
7	,	,	,	,	_	10	punct	_	_
8	terminally	terminally	RB	RB	_	10	advmod	_	_
9	differentiated	differentiate	VBN	VBN	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	0	root	_	_
11	that	that	WDT	WDT	_	14	nsubj	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	14	advmod	_	_
14	undergo	undergo	VBP	VBP	_	10	acl:relcl	_	_
15	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	death	death	NN	NN	_	14	dobj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	apoptosis	apoptosis	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	onset	onset	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	both	both	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	types	type	NNS	NNS	_	4	nmod	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	delayed	delay	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	hemopoietins	hemopoietin	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	mediators	mediator	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	there	there	EX	EX	_	6	expl	_	_
3	have	have	VBP	VBP	_	6	aux	_	_
4	been	be	VBN	VBN	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	35	advcl	_	_
7	of	of	IN	IN	_	8	case	_	_
8	reports	report	NNS	NNS	_	6	nmod	_	_
9	demonstrating	demonstrate	VBG	VBG	_	6	acl	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	17	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	particular	particular	JJ	JJ	_	15	nmod	_	_
15	dexamethasone	dexamethasone	NN	NN	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	antagonize	antagonize	VBP	VBP	_	9	ccomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	eosinophil	eosinophil	NN	NN	_	21	compound	_	_
20	life-prolonging	life-prolonging	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	17	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	hemopoietins	hemopoietin	NNS	NNS	_	21	nmod	_	_
24	,	,	,	,	_	35	punct	_	_
25	direct	direct	JJ	JJ	_	26	amod	_	_
26	effects	effect	NNS	NNS	_	35	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	dexamethasone	dexamethasone	NN	NN	_	26	nmod	_	_
29	on	on	IN	IN	_	31	case	_	_
30	eosinophil	eosinophil	NN	NN	_	31	compound	_	_
31	apoptosis	apoptosis	NN	NN	_	26	nmod	_	_
32	have	have	VBP	VBP	_	35	aux	_	_
33	not	not	RB	RB	_	35	neg	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	documented	document	VBN	VBN	_	0	root	_	_
36	.	.	.	.	_	35	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	examined	examine	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	direct	direct	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	glucocorticoids	glucocorticoid	NNS	NNS	_	8	nmod	_	_
11	on	on	IN	IN	_	12	case	_	_
12	eosinophil	eosinophil	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	neutrophil	neutrophil	NN	NN	_	12	conj	_	_
15	apoptosis	apoptosis	NN	NN	_	12	dep	_	_
16	in	in	IN	IN	_	17	case	_	_
17	light	light	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
20	common	common	JJ	JJ	_	21	amod	_	_
21	therapeutic	therapeutic	JJ	JJ	_	22	amod	_	_
22	use	use	NN	NN	_	17	nmod	_	_
23	as	as	IN	IN	_	24	case	_	_
24	anti-inflammatory	anti-inflammatory	JJ	JJ	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	anti-allergic/hypereosinophilic	anti-allergic/hypereosinophilic	JJ	JJ	_	24	conj	_	_
27	agents	agent	NNS	NNS	_	24	dep	_	_
28	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	treatment	treatment	NN	NN	_	7	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	dexamethasone	dexamethasone	NN	NN	_	4	nmod	_	_
7	induced	induce	VBD	VBD	_	2	ccomp	_	_
8	eosinophil	eosinophil	NN	NN	_	9	compound	_	_
9	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	dexamethasone	dexamethasone	NN	NN	_	8	nsubj	_	_
5	was	be	VBD	VBD	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	inhibitor	inhibitor	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	neutrophil	neutrophil	NN	NN	_	11	compound	_	_
11	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	dexamethasone	dexamethasone	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	both	both	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	types	type	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	through	through	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	i.e.	i.e.	FW	FW	_	10	advcl	_	_
17	,	,	,	,	_	10	punct	_	_
18	it	it	PRP	PRP	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	abolished	abolish	VBN	VBN	_	10	parataxis	_	_
21	by	by	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	antagonist	antagonist	NN	NN	_	20	nmod	_	_
26	RU38486	ru38486	NN	NN	_	25	dep	_	_
27	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	description	description	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	an	a	DT	DT	_	8	det	_	_
8	agent	agent	NN	NN	_	5	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	promotes	promote	VBZ	VBZ	_	8	acl:relcl	_	_
11	eosinophil	eosinophil	NN	NN	_	12	compound	_	_
12	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
13	while	while	IN	IN	_	14	mark	_	_
14	inhibiting	inhibit	VBG	VBG	_	10	advcl	_	_
15	neutrophil	neutrophil	NN	NN	_	16	compound	_	_
16	apoptosis	apoptosis	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	5	punct	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	thus	thus	RB	RB	_	20	advmod	_	_
20	presents	present	VBZ	VBZ	_	5	conj	_	_
21	a	a	DT	DT	_	23	det	_	_
22	novel	novel	JJ	JJ	_	23	amod	_	_
23	approach	approach	NN	NN	_	20	dobj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	study	study	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	control	control	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	apoptosis	apoptosis	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	36	case	_	_
32	these	these	DT	DT	_	36	det	_	_
33	closely	closely	RB	RB	_	34	advmod	_	_
34	related	related	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	types	type	NNS	NNS	_	30	nmod	_	_
37	as	as	RB	RB	_	20	cc	_	_
38	well	well	RB	RB	_	37	mwe	_	_
39	as	as	IN	IN	_	37	mwe	_	_
40	increases	increase	VBZ	VBZ	_	20	conj	_	_
41	our	we	PRP$	PRP$	_	42	nmod:poss	_	_
42	understanding	understanding	NN	NN	_	40	dobj	_	_
43	of	of	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	clinical	clinical	JJ	JJ	_	46	amod	_	_
46	action	action	NN	NN	_	42	nmod	_	_
47	of	of	IN	IN	_	48	case	_	_
48	glucocorticoids	glucocorticoid	NNS	NNS	_	46	nmod	_	_
49	in	in	IN	IN	_	50	case	_	_
50	inflammation	inflammation	NN	NN	_	46	nmod	_	_
51	.	.	.	.	_	5	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	2	amod	_	_
2	NFAT1	nfat1	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	NFATp	nfatp	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	regulated	regulate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	calcineurin	calcineurin	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	mediates	mediate	VBZ	VBZ	_	7	conj	_	_
15	transcription	transcription	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	several	several	JJ	JJ	_	19	amod	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NFAT	nfat	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	2	nmod	_	_
7	play	play	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	key	key	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	transcription	transcription	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	16	conj	_	_
20	during	during	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	7	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	isoforms	isoform	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	NFAT1	nfat1	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	11	punct	_	_
13	previously	previously	RB	RB	_	14	advmod	_	_
14	termed	term	VBN	VBN	_	11	acl	_	_
15	NFATp	nfatp	NN	NN	_	14	xcomp	_	_
16	)	)	-RRB-	-RRB-	_	11	punct	_	_
17	that	that	WDT	WDT	_	21	nsubj	_	_
18	are	be	VBP	VBP	_	21	cop	_	_
19	the	the	DT	DT	_	21	det	_	_
20	predominant	predominant	JJ	JJ	_	21	amod	_	_
21	isoforms	isoform	NNS	NNS	_	6	acl:relcl	_	_
22	expressed	express	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	28	case	_	_
24	murine	murine	JJ	JJ	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	human	human	JJ	JJ	_	24	conj	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	expressed	express	VBN	VBN	_	11	advcl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	Jurkat	jurkat	NN	NN	_	6	compound	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	recombinant	recombinant	JJ	JJ	_	9	amod	_	_
9	NFAT1	nfat1	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	expected	expect	VBN	VBN	_	11	advcl	_	_
15	,	,	,	,	_	11	punct	_	_
16	by	by	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	calmodulin-dependent	calmodulin-dependent	JJ	JJ	_	20	amod	_	_
19	phosphatase	phosphatase	NN	NN	_	20	compound	_	_
20	calcineurin	calcineurin	NN	NN	_	11	nmod	_	_
21	,	,	,	,	_	11	punct	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	function	function	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	inhibited	inhibit	VBN	VBN	_	11	conj	_	_
27	by	by	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	immunosuppressive	immunosuppressive	JJ	JJ	_	30	amod	_	_
30	agent	agent	NN	NN	_	26	nmod	_	_
31	cyclosporin	cyclosporin	NN	NN	_	32	compound	_	_
32	A	a	NN	NN	_	30	dep	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	CsA	csa	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	11	punct	_	_

1	Transactivation	transactivation	NN	NN	_	9	nsubj	_	_
2	by	by	IN	IN	_	4	case	_	_
3	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
4	NFAT1	nfat1	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	Jurkat	jurkat	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	dual	dual	JJ	JJ	_	11	amod	_	_
11	stimulation	stimulation	NN	NN	_	9	dobj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	ionomycin	ionomycin	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	phorbol	phorbol	NN	NN	_	17	compound	_	_
16	12-myristate	12-myristate	NN	NN	_	17	compound	_	_
17	13-acetate	13-acetate	NN	NN	_	13	conj	_	_
18	;	;	:	:	_	9	punct	_	_
19	this	this	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	potentiated	potentiate	VBN	VBN	_	9	parataxis	_	_
23	by	by	IN	IN	_	24	case	_	_
24	coexpression	coexpression	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	constitutively	constitutively	RB	RB	_	27	advmod	_	_
27	active	active	JJ	JJ	_	28	amod	_	_
28	calcineurin	calcineurin	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	inhibited	inhibit	VBN	VBN	_	22	conj	_	_
32	by	by	IN	IN	_	33	case	_	_
33	CsA	csa	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	22	punct	_	_

1	Immunocytochemical	immunocytochemical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	recombinant	recombinant	JJ	JJ	_	6	amod	_	_
6	NFAT1	nfat1	NN	NN	_	7	nsubj	_	_
7	localizes	localize	VBZ	VBZ	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cytoplasm	cytoplasm	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	transiently	transiently	RB	RB	_	13	advmod	_	_
13	transfected	transfect	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	translocates	translocate	VBZ	VBZ	_	7	conj	_	_
18	into	into	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nucleus	nucleus	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	CsA-sensitive	csa-sensitive	JJ	JJ	_	24	amod	_	_
24	manner	manner	NN	NN	_	17	nmod	_	_
25	following	follow	VBG	VBG	_	27	case	_	_
26	ionomycin	ionomycin	NN	NN	_	27	compound	_	_
27	stimulation	stimulation	NN	NN	_	17	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	expressed	express	VBN	VBN	_	11	advcl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	COS	cos	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	however	however	RB	RB	_	11	advmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	NFAT1	nfat1	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	capable	capable	JJ	JJ	_	0	root	_	_
12	of	of	IN	IN	_	13	case	_	_
13	transactivation	transactivation	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	but	but	CC	CC	_	11	cc	_	_
16	it	it	PRP	PRP	_	19	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	regulated	regulate	VBN	VBN	_	11	conj	_	_
20	correctly	correctly	RB	RB	_	19	advmod	_	_
21	:	:	:	:	_	11	punct	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	subcellular	subcellular	JJ	JJ	_	24	amod	_	_
24	localization	localization	NN	NN	_	30	nsubjpass	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	function	function	NN	NN	_	24	conj	_	_
28	are	be	VBP	VBP	_	30	auxpass	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	affected	affect	VBN	VBN	_	11	parataxis	_	_
31	by	by	IN	IN	_	32	case	_	_
32	stimulation	stimulation	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	COS	cos	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	32	nmod	_	_
37	with	with	IN	IN	_	38	case	_	_
38	ionomycin	ionomycin	NN	NN	_	32	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	phorbol	phorbol	NN	NN	_	42	compound	_	_
41	12-myristate	12-myristate	NN	NN	_	42	compound	_	_
42	13-acetate	13-acetate	NN	NN	_	38	conj	_	_
43	.	.	.	.	_	30	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	2	amod	_	_
2	NFAT1	nfat1	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	mediate	mediate	VB	VB	_	0	root	_	_
5	transcription	transcription	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	21	case	_	_
7	the	the	DT	DT	_	21	det	_	_
8	interleukin-2	interleukin-2	NN	NN	_	21	compound	_	_
9	,	,	,	,	_	8	punct	_	_
10	interleukin-4	interleukin-4	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	tumor	tumor	NN	NN	_	15	compound	_	_
13	necrosis	necrosis	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	8	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	20	amod	_	_
19	colony-stimulating	colony-stimulating	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	8	conj	_	_
21	promoters	promoter	NNS	NNS	_	5	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	5	nmod	_	_
25	,	,	,	,	_	4	punct	_	_
26	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
27	that	that	IN	IN	_	29	mark	_	_
28	NFAT1	nfat1	NN	NN	_	29	nsubj	_	_
29	contributes	contribute	VBZ	VBZ	_	26	ccomp	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	CsA-sensitive	csa-sensitive	JJ	JJ	_	33	amod	_	_
33	transcription	transcription	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	genes	gene	NNS	NNS	_	33	nmod	_	_
37	during	during	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	immune	immune	JJ	JJ	_	40	amod	_	_
40	response	response	NN	NN	_	33	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	4	amod	_	_
2	virus	virus	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	antigen	antigen	NN	NN	_	11	nsubj	_	_
5	2	2	CD	CD	_	4	nummod	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	latent	latent	JJ	JJ	_	9	amod	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	4	conj	_	_
10	independently	independently	RB	RB	_	11	advmod	_	_
11	transactivate	transactivate	VBP	VBP	_	0	root	_	_
12	p53	p53	NN	NN	_	11	dobj	_	_
13	through	through	IN	IN	_	14	case	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	B-cell	b-cell	NN	NN	_	2	compound	_	_
2	immortalization	immortalization	NN	NN	_	10	nsubj	_	_
3	by	by	IN	IN	_	5	case	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
5	virus	virus	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EBV	ebv	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	permanent	permanent	JJ	JJ	_	13	amod	_	_
13	control	control	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	processes	process	NNS	NNS	_	13	nmod	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	normally	normally	RB	RB	_	20	advmod	_	_
20	regulate	regulate	VB	VB	_	17	acl:relcl	_	_
21	cell	cell	NN	NN	_	20	dobj	_	_
22	division	division	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	apoptosis	apoptosis	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	functions	function	NNS	NNS	_	21	appos	_	_
27	possessed	possess	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	29	case	_	_
29	p53	p53	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	number	number	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	normal	normal	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	types	type	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	studies	study	NNS	NNS	_	17	nmod	_	_
3	initiated	initiate	VBN	VBN	_	2	acl	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	evaluate	evaluate	VB	VB	_	3	xcomp	_	_
6	relationships	relationship	NNS	NNS	_	5	dobj	_	_
7	between	between	IN	IN	_	10	case	_	_
8	EBV	ebv	NN	NN	_	10	compound	_	_
9	latent	latent	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	p53	p53	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	17	punct	_	_
14	p53	p53	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	17	nsubjpass	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	increase	increase	VB	VB	_	17	xcomp	_	_
20	approximately	approximately	RB	RB	_	21	advmod	_	_
21	10-fold	10-fold	RB	RB	_	19	advmod	_	_
22	4	4	CD	CD	_	24	compound	_	_
23	to	to	TO	TO	_	24	dep	_	_
24	5	5	CD	CD	_	25	nummod	_	_
25	days	day	NNS	NNS	_	19	nmod	_	_
26	after	after	IN	IN	_	25	case	_	_
27	EBV	ebv	NN	NN	_	28	compound	_	_
28	infection	infection	NN	NN	_	25	dep	_	_
29	of	of	IN	IN	_	34	case	_	_
30	purified	purify	VBN	VBN	_	34	amod	_	_
31	resting	rest	VBG	VBG	_	34	amod	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	;	;	:	:	_	17	punct	_	_
36	the	the	DT	DT	_	38	det	_	_
37	induced	induce	VBN	VBN	_	38	amod	_	_
38	p53	p53	NN	NN	_	41	nsubj	_	_
39	was	be	VBD	VBD	_	41	cop	_	_
40	transcriptionally	transcriptionally	RB	RB	_	41	advmod	_	_
41	active	active	JJ	JJ	_	17	parataxis	_	_
42	.	.	.	.	_	41	punct	_	_

1	Latent	latent	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	16	csubj	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	,	,	,	,	_	14	punct	_	_
7	to	to	TO	TO	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	lesser	lesser	JJR	JJR	_	10	amod	_	_
10	extent	extent	NN	NN	_	14	dep	_	_
11	,	,	,	,	_	14	punct	_	_
12	EBV	ebv	NN	NN	_	14	compound	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	antigen	antigen	NN	NN	_	3	conj	_	_
15	2	2	CD	CD	_	14	nummod	_	_
16	mediated	mediate	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	increase	increase	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	p53	p53	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	18	nmod	_	_
22	via	via	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	28	compound	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	Interleukin	interleukin	NN	NN	_	5	compound	_	_
2	10	10	CD	CD	_	1	nummod	_	_
3	induced	induced	JJ	JJ	_	5	amod	_	_
4	c-fos	c-fos	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	divergent	divergent	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	kinases	kinase	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	IL-10	il-10	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potent	potent	JJ	JJ	_	5	amod	_	_
5	mediator	mediator	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	growth	growth	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	plasma	plasma	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	formation	formation	NN	NN	_	10	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transduction	transduction	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-10	il-10	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	poorly	poorly	RB	RB	_	12	advmod	_	_
12	understood	understand	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-10	il-10	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	protooncogene	protooncogene	NN	NN	_	14	compound	_	_
14	c-fos	c-fos	NN	NN	_	10	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	investigated	investigate	VBN	VBN	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	because	because	IN	IN	_	20	mark	_	_
19	Fos	fos	NN	NN	_	20	nsubj	_	_
20	plays	play	VBZ	VBZ	_	16	advcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	potential	potential	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regulation	regulation	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	26	nmod	_	_
30	proliferation	proliferation	NN	NN	_	29	dep	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	differentiation	differentiation	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	16	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	purified	purify	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	8	case	_	_
6	buffy	buffy	JJ	JJ	_	8	amod	_	_
7	coat	coat	NN	NN	_	8	compound	_	_
8	preparations	preparation	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	healthy	healthy	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	donors	donor	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	positive	positive	JJ	JJ	_	15	amod	_	_
15	selection	selection	NN	NN	_	4	nmod	_	_
16	using	use	VBG	VBG	_	15	acl	_	_
17	an	a	DT	DT	_	21	det	_	_
18	anti	anti	JJ	JJ	_	21	amod	_	_
19	CD20	cd20	NN	NN	_	21	compound	_	_
20	monoclonal	monoclonal	JJ	JJ	_	21	amod	_	_
21	antibody	antibody	NN	NN	_	16	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	26	det	_	_
24	MiniMACS	minimacs	NN	NN	_	26	compound	_	_
25	separation	separation	NN	NN	_	26	compound	_	_
26	unit	unit	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	4	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	prestimulated	prestimulate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	SAC	sac	NN	NN	_	4	nmod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	48	48	CD	CD	_	9	nummod	_	_
9	hrs	hr	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Then	then	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	incubated	incubate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	medium	medium	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	100	100	CD	CD	_	12	nummod	_	_
12	ng/ml	ng/ml	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	for	for	IN	IN	_	18	case	_	_
15	10	10	CD	CD	_	17	compound	_	_
16	to	to	TO	TO	_	17	dep	_	_
17	120	120	CD	CD	_	18	nummod	_	_
18	min	min	NN	NN	_	5	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	RNA	rna	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	extracted	extract	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	5	case	_	_
5	phenol/chloroform	phenol/chloroform	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	analyzed	analyze	VBN	VBN	_	3	conj	_	_
11	by	by	IN	IN	_	15	case	_	_
12	PCR	pcr	NN	NN	_	15	compound	_	_
13	assisted	assisted	JJ	JJ	_	15	amod	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	assay	assay	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	significant	significant	JJ	JJ	_	5	amod	_	_
3	2-4	2-4	CD	CD	_	4	dep	_	_
4	fold	fold	JJ	JJ	_	2	dep	_	_
5	increase	increase	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	within	within	IN	IN	_	13	case	_	_
12	30	30	CD	CD	_	13	nummod	_	_
13	min	min	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	IL-10	il-10	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	p	p	NN	NN	_	10	dep	_	_
20	&lt;	&lt;	JJR	JJR	_	19	amod	_	_
21	0.01	0.01	CD	CD	_	20	dep	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	.	.	.	.	_	10	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	2	2	CD	CD	_	3	nummod	_	_
3	hrs	hr	NNS	NNS	_	6	nmod	_	_
4	c-fos	c-fos	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	6	nsubj	_	_
6	declined	decline	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	basal	basal	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IL-10	il-10	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	dose-dependent	dose-dependent	JJ	JJ	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	maximum	maximum	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	6	nmod	_	_
11	using	use	VBG	VBG	_	10	acl	_	_
12	100	100	CD	CD	_	13	nummod	_	_
13	ng/ml	ng/ml	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IL-10	il-10	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-10	il-10	NN	NN	_	3	compound	_	_
3	effect	effect	NN	NN	_	9	nsubjpass	_	_
4	on	on	IN	IN	_	6	case	_	_
5	c-fos	c-fos	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	polymyxin	polymyxin	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	6	det	_	_
3	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
4	kinase	kinase	NN	NN	_	6	compound	_	_
5	inhibitor	inhibitor	NN	NN	_	6	compound	_	_
6	genistein	genistein	NN	NN	_	1	dobj	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	10	10	CD	CD	_	9	nummod	_	_
9	microM	microm	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	complete	complete	JJ	JJ	_	13	amod	_	_
13	inhibition	inhibition	NN	NN	_	20	nsubjpass	_	_
14	of	of	IN	IN	_	18	case	_	_
15	IL-10	il-10	NN	NN	_	18	compound	_	_
16	induced	induced	JJ	JJ	_	18	amod	_	_
17	c-fos	c-fos	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	13	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	observed	observe	VBN	VBN	_	1	parataxis	_	_
21	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	H-7	h-7	NN	NN	_	18	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	10	10	CD	CD	_	7	nummod	_	_
7	microM	microm	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	4	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	inhibitor	inhibitor	NN	NN	_	4	appos	_	_
13	of	of	IN	IN	_	15	case	_	_
14	serine/threonine	serine/threonine	NN	NN	_	15	compound	_	_
15	kinases	kinase	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	blocked	block	VBD	VBD	_	0	root	_	_
19	IL-10	il-10	NN	NN	_	22	compound	_	_
20	mediated	mediated	JJ	JJ	_	22	amod	_	_
21	c-fos	c-fos	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	dobj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	p	p	NN	NN	_	18	dep	_	_
25	&lt;	&lt;	JJR	JJR	_	24	amod	_	_
26	0.05	0.05	CD	CD	_	25	dep	_	_
27	)	)	-RRB-	-RRB-	_	24	punct	_	_
28	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	IL-10	il-10	NN	NN	_	9	nsubj	_	_
9	induces	induce	VBZ	VBZ	_	6	ccomp	_	_
10	c-fos	c-fos	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	B-cells	b-cell	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	9	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	tyrosine	tyrosine	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	serine/threonine	serine/threonine	NN	NN	_	21	compound	_	_
21	kinases	kinase	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	this	this	DT	DT	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	report	report	NN	NN	_	16	advcl	_	_
7	on	on	IN	IN	_	11	case	_	_
8	IL-10	il-10	NN	NN	_	11	compound	_	_
9	induced	induced	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	these	these	DT	DT	_	14	det	_	_
14	data	datum	NNS	NNS	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	help	help	VB	VB	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	identify	identify	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
21	mechanisms	mechanism	NNS	NNS	_	18	dobj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	25	nmod	_	_
24	IL-10	il-10	NN	NN	_	25	nsubj	_	_
25	stimulates	stimulate	VBZ	VBZ	_	21	acl:relcl	_	_
26	human	human	JJ	JJ	_	27	amod	_	_
27	B-cells	b-cell	NNS	NNS	_	25	dobj	_	_
28	.	.	.	.	_	16	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	alternatively	alternatively	RB	RB	_	3	advmod	_	_
3	spliced	splice	VBN	VBN	_	4	amod	_	_
4	isoform	isoform	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	Spi-B	spi-b	NN	NN	_	4	nmod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	7	dep	_	_
10	.	.	.	.	_	4	punct	_	_

1	Spi-B	spi-b	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	Ets	ets	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	0	root	_	_
7	related	related	JJ	JJ	_	6	amod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	oncoprotein	oncoprotein	NN	NN	_	7	nmod	_	_
11	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	highly	highly	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	6	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Ets	ets	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	share	share	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	conserved	conserve	VBN	VBN	_	8	amod	_	_
7	Ets	ets	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	4	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	mediates	mediate	VBZ	VBZ	_	8	acl:relcl	_	_
11	specific	specific	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	Spi-B	spi-b	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	2	dobj	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	a	a	DT	DT	_	8	det	_	_
7	core	core	NN	NN	_	8	compound	_	_
8	5'-GGAA-3'	5'-ggaa-3'	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	activates	activate	VBZ	VBZ	_	2	conj	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	through	through	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	motif	motif	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Up	up	IN	IN	_	3	case	_	_
2	to	to	TO	TO	_	3	case	_	_
3	date	date	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	biological	biological	JJ	JJ	_	7	amod	_	_
7	function	function	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Spi-B	spi-b	NN	NN	_	7	nmod	_	_
10	remains	remain	VBZ	VBZ	_	0	root	_	_
11	unknown	unknown	JJ	JJ	_	10	xcomp	_	_
12	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	describe	describe	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	characterization	characterization	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	alternatively	alternatively	RB	RB	_	10	advmod	_	_
10	spliced	splice	VBN	VBN	_	11	amod	_	_
11	variant	variant	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Spi-B	spi-b	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	named	name	VBN	VBN	_	11	acl	_	_
16	deltaSpi-B	deltaspi-b	NN	NN	_	15	xcomp	_	_
17	,	,	,	,	_	11	punct	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	has	have	VBZ	VBZ	_	20	aux	_	_
20	lost	lose	VBN	VBN	_	11	acl:relcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	Ets	ets	NN	NN	_	23	compound	_	_
23	domain	domain	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	deltaspi-B	deltaspi-b	NN	NN	_	11	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	spi-B	spi-b	NN	NN	_	6	conj	_	_
9	mRNAs	mrna	NNS	NNS	_	6	dep	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	present	present	JJ	JJ	_	0	root	_	_
12	simultaneously	simultaneously	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	ratio	ratio	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	around	around	IN	IN	_	18	advmod	_	_
18	10	10	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	DeltaSpi-B	deltaspi-b	NN	NN	_	2	compound	_	_
2	product	product	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	bind	bind	VB	VB	_	5	xcomp	_	_
8	DNA	dna	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	recovered	recover	VBN	VBN	_	5	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	15	amod	_	_
14	cellular	cellular	JJ	JJ	_	15	amod	_	_
15	extracts	extract	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	raise	raise	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	delta	delta	NN	NN	_	7	compound	_	_
7	Spi-B	spi-b	NN	NN	_	9	nsubj	_	_
8	might	might	MD	MD	_	9	aux	_	_
9	affect	affect	VB	VB	_	4	ccomp	_	_
10	Spi-B	spi-b	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	recruiting	recruit	VBG	VBG	_	9	advcl	_	_
14	factors	factor	NNS	NNS	_	13	dobj	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	Spi-B	spi-b	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	utilization	utilization	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	Janus	janus	NN	NN	_	6	nmod:npmod	_	_
5	kinase-signal	kinase-signal	JJ	JJ	_	6	dep	_	_
6	transducer	transducer	NN	NN	_	7	amod	_	_
7	activator	activator	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathways	pathway	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	stimulation	stimulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	natural	natural	JJ	JJ	_	19	amod	_	_
18	killer	killer	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	IL-2	il-2	NN	NN	_	14	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	IL-12	il-12	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	IFN-alpha	ifn-alpha	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	IL-2-	il-2-	NN	NN	_	8	amod	_	_
2	,	,	,	,	_	1	punct	_	_
3	IL-12-	il-12-	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	IFN-alpha-mediated	ifn-alpha-mediated	JJ	JJ	_	1	conj	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	pathways	pathway	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	analyzed	analyze	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	primary	primary	JJ	JJ	_	14	amod	_	_
13	NK	nk	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	NK3.3	nk3.3	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	mobility	mobility	NN	NN	_	3	compound	_	_
3	shift	shift	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	immunoprecipitation	immunoprecipitation	NN	NN	_	3	conj	_	_
6	analyses	analysis	NNS	NNS	_	7	nsubj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	26	mark	_	_
9	in	in	IN	IN	_	12	case	_	_
10	addition	addition	NN	NN	_	12	dep	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	activating	activate	VBG	VBG	_	26	advcl	_	_
13	STAT3	stat3	NN	NN	_	12	dobj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	signal	signal	NN	NN	_	16	compound	_	_
16	transducer	transducer	NN	NN	_	13	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activator	activator	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	transcription-3	transcription-3	NN	NN	_	16	nmod	_	_
21	)	)	-RRB-	-RRB-	_	16	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	STAT5	stat5	NN	NN	_	13	conj	_	_
24	,	,	,	,	_	26	punct	_	_
25	IL-2	il-2	NN	NN	_	26	nsubj	_	_
26	induced	induce	VBD	VBD	_	7	ccomp	_	_
27	tyrosine	tyrosine	NN	NN	_	30	compound	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	serine	serine	NN	NN	_	27	conj	_	_
30	phosphorylation	phosphorylation	NN	NN	_	26	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	STAT1	stat1	NN	NN	_	33	compound	_	_
33	alpha	alpha	NN	NN	_	30	nmod	_	_
34	,	,	,	,	_	30	punct	_	_
35	which	which	WDT	WDT	_	36	nsubj	_	_
36	formed	form	VBD	VBD	_	30	acl:relcl	_	_
37	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	39	amod	_	_
38	sequence-binding	sequence-binding	NN	NN	_	39	compound	_	_
39	complexes	complex	NNS	NNS	_	36	dobj	_	_
40	by	by	IN	IN	_	41	case	_	_
41	itself	itself	PRP	PRP	_	36	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	with	with	IN	IN	_	44	case	_	_
44	STAT3	stat3	NN	NN	_	41	conj	_	_
45	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	IL-2	il-2	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IFN-alpha	ifn-alpha	NN	NN	_	2	conj	_	_
5	activated	activate	VBD	VBD	_	13	advcl	_	_
6	STAT1	stat1	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	STAT5	stat5	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	13	punct	_	_
11	IL-2	il-2	NN	NN	_	13	nsubj	_	_
12	predominantly	predominantly	RB	RB	_	13	advmod	_	_
13	activated	activate	VBN	VBN	_	0	root	_	_
14	STAT5	stat5	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	13	punct	_	_
16	while	while	IN	IN	_	19	mark	_	_
17	IFN-alpha	ifn-alpha	NN	NN	_	19	nsubj	_	_
18	predominantly	predominantly	RB	RB	_	19	advmod	_	_
19	activated	activate	VBD	VBD	_	13	advcl	_	_
20	STAT1	stat1	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	13	punct	_	_

1	IL-2	il-2	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	less	less	RBR	RBR	_	6	advmod	_	_
4	STAT1	stat1	NN	NN	_	6	compound	_	_
5	alpha	alpha	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	dobj	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	IFN-alpha	ifn-alpha	NN	NN	_	9	nsubj	_	_
9	induced	induce	VBD	VBD	_	2	conj	_	_
10	greater	greater	JJR	JJR	_	12	amod	_	_
11	STAT5	stat5	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	NK3.3	nk3.3	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	2	nmod	_	_
16	compared	compare	VBN	VBN	_	21	case	_	_
17	with	with	IN	IN	_	21	case	_	_
18	preactivated	preactivated	JJ	JJ	_	21	amod	_	_
19	primary	primary	JJ	JJ	_	21	amod	_	_
20	NK	nk	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	2	advcl	_	_
22	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	NK3.3	nk3.3	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	IL-2	il-2	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	comparable	comparable	JJ	JJ	_	8	amod	_	_
8	formation	formation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	16	case	_	_
10	c-fos	c-fos	NN	NN	_	15	nmod:npmod	_	_
11	promoter	promoter	NN	NN	_	15	nmod:npmod	_	_
12	sis-inducible	sis-inducible	JJ	JJ	_	15	amod	_	_
13	element	element	NN	NN	_	15	nmod:npmod	_	_
14	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	15	amod	_	_
15	sequence-binding	sequence-binding	NN	NN	_	16	amod	_	_
16	complexes	complex	NNS	NNS	_	8	nmod	_	_
17	containing	contain	VBG	VBG	_	16	acl	_	_
18	STAT3	stat3	NN	NN	_	17	dobj	_	_
19	alone	alone	RB	RB	_	18	advmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	complexes	complex	NNS	NNS	_	8	nmod	_	_
22	containing	contain	VBG	VBG	_	21	acl	_	_
23	STAT3	stat3	NN	NN	_	22	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	STAT1	stat1	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	23	conj	_	_
27	,	,	,	,	_	6	punct	_	_
28	while	while	IN	IN	_	37	mark	_	_
29	in	in	IN	IN	_	33	case	_	_
30	preactivated	preactivated	JJ	JJ	_	33	amod	_	_
31	primary	primary	JJ	JJ	_	33	amod	_	_
32	NK	nk	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	37	nmod	_	_
34	,	,	,	,	_	37	punct	_	_
35	it	it	PRP	PRP	_	37	nsubj	_	_
36	preferentially	preferentially	RB	RB	_	37	advmod	_	_
37	induced	induce	VBD	VBD	_	6	advcl	_	_
38	complexes	complex	NNS	NNS	_	37	dobj	_	_
39	containing	contain	VBG	VBG	_	38	acl	_	_
40	STAT3	stat3	NN	NN	_	39	dobj	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	STAT1	stat1	NN	NN	_	43	compound	_	_
43	alpha	alpha	NN	NN	_	40	conj	_	_
44	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	signaling	signaling	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	NK3.3	nk3.3	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	always	always	RB	RB	_	10	advmod	_	_
10	identical	identical	JJ	JJ	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	primary	primary	JJ	JJ	_	16	amod	_	_
15	NK	nk	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	contrast	contrast	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	IL-2	il-2	NN	NN	_	9	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	9	punct	_	_
8	IL-12	il-12	NN	NN	_	9	nsubj	_	_
9	induced	induce	VBD	VBD	_	0	root	_	_
10	strong	strong	JJ	JJ	_	12	amod	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	STAT4	stat4	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	variable	variable	JJ	JJ	_	18	amod	_	_
17	weak	weak	JJ	JJ	_	18	amod	_	_
18	phosphorylation	phosphorylation	NN	NN	_	12	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	STAT3	stat3	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	supershift	supershift	NN	NN	_	4	compound	_	_
4	analyses	analysis	NNS	NNS	_	12	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	11	det	_	_
7	c-fos	c-fos	NN	NN	_	11	compound	_	_
8	promoter	promoter	NN	NN	_	11	compound	_	_
9	sis-inducible	sis-inducible	JJ	JJ	_	11	amod	_	_
10	element	element	NN	NN	_	11	compound	_	_
11	probe	probe	NN	NN	_	5	dobj	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	15	mark	_	_
14	IL-12	il-12	NN	NN	_	15	nsubj	_	_
15	activated	activate	VBD	VBD	_	12	ccomp	_	_
16	STAT4	stat4	NN	NN	_	15	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	STAT1	stat1	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	STAT3	stat3	NN	NN	_	16	conj	_	_
23	,	,	,	,	_	15	punct	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	induced	induce	VBD	VBD	_	15	conj	_	_
26	complexes	complex	NNS	NNS	_	25	dobj	_	_
27	containing	contain	VBG	VBG	_	26	acl	_	_
28	STAT4	stat4	NN	NN	_	27	dobj	_	_
29	only	only	RB	RB	_	28	advmod	_	_
30	,	,	,	,	_	28	punct	_	_
31	STAT4	stat4	NN	NN	_	28	conj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	STAT1	stat1	NN	NN	_	34	compound	_	_
34	alpha	alpha	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	28	punct	_	_
36	STAT3	stat3	NN	NN	_	28	conj	_	_
37	with	with	IN	IN	_	39	case	_	_
38	STAT1	stat1	NN	NN	_	39	compound	_	_
39	alpha	alpha	NN	NN	_	36	nmod	_	_
40	,	,	,	,	_	28	punct	_	_
41	or	or	CC	CC	_	28	cc	_	_
42	STAT1	stat1	NN	NN	_	43	compound	_	_
43	alpha	alpha	NN	NN	_	28	conj	_	_
44	only	only	RB	RB	_	43	advmod	_	_
45	in	in	IN	IN	_	49	case	_	_
46	preactivated	preactivated	JJ	JJ	_	49	amod	_	_
47	primary	primary	JJ	JJ	_	49	amod	_	_
48	NK	nk	NN	NN	_	49	compound	_	_
49	cells	cell	NNS	NNS	_	15	nmod	_	_
50	.	.	.	.	_	12	punct	_	_

1	STAT1	stat1	NN	NN	_	3	compound	_	_
2	alpha	alpha	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	6	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	IL-12	il-12	NN	NN	_	3	nmod	_	_
6	correlated	correlate	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	serine	serine	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	11	cc	_	_
15	tyrosine	tyrosine	NN	NN	_	11	conj	_	_
16	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-2	il-2	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	JAK1	jak1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	JAK3	jak3	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	while	while	IN	IN	_	14	mark	_	_
13	IL-12	il-12	NN	NN	_	14	nsubj	_	_
14	induced	induce	VBD	VBD	_	4	advcl	_	_
15	phosphorylation	phosphorylation	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	JAK2	jak2	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	TYK2	tyk2	NN	NN	_	17	conj	_	_
20	in	in	IN	IN	_	27	case	_	_
21	both	both	CC	CC	_	24	cc:preconj	_	_
22	preactivated	preactivated	JJ	JJ	_	24	amod	_	_
23	primary	primary	JJ	JJ	_	24	amod	_	_
24	NK	nk	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	NK3.3	nk3.3	NN	NN	_	24	conj	_	_
27	cells	cell	NNS	NNS	_	14	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	phosphorylation	phosphorylation	NN	NN	_	22	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	consequent	consequent	JJ	JJ	_	6	amod	_	_
5	differential	differential	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	2	conj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	separate	separate	JJ	JJ	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	overlapping	overlapping	JJ	JJ	_	9	conj	_	_
12	STAT	stat	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	2	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	IL-2	il-2	NN	NN	_	2	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	IL-12	il-12	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	IFN-alpha	ifn-alpha	NN	NN	_	15	conj	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	provide	provide	VB	VB	_	0	root	_	_
23	a	a	DT	DT	_	25	det	_	_
24	molecular	molecular	JJ	JJ	_	25	amod	_	_
25	basis	basis	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	similarities	similarity	NNS	NNS	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	differences	difference	NNS	NNS	_	28	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	actions	action	NNS	NNS	_	28	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	cytokines	cytokine	NNS	NNS	_	33	nmod	_	_
37	on	on	IN	IN	_	39	case	_	_
38	NK	nk	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	33	nmod	_	_
40	.	.	.	.	_	22	punct	_	_

1	Sublethal	sublethal	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	oxidative	oxidative	JJ	JJ	_	5	amod	_	_
5	stress	stress	NN	NN	_	2	nmod	_	_
6	stimulate	stimulate	VBP	VBP	_	0	root	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-jun	c-jun	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	suppress	suppress	VBP	VBP	_	6	conj	_	_
13	IL-2	il-2	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	Jurkat	jurkat	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Sublethal	sublethal	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	oxidative	oxidative	JJ	JJ	_	5	amod	_	_
5	stress	stress	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	well	well	RB	RB	_	8	advmod	_	_
8	known	know	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	alter	alter	VB	VB	_	8	xcomp	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	10	dobj	_	_
15	,	,	,	,	_	8	punct	_	_
16	but	but	CC	CC	_	8	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	underlying	underlying	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	21	nsubj	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	unknown	unknown	JJ	JJ	_	8	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	oxidative	oxidative	JJ	JJ	_	9	amod	_	_
9	stress	stress	NN	NN	_	6	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activities	activity	NNS	NNS	_	6	nmod	_	_
13	mediated	mediate	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	c-Fos/c-Jun	c-fos/c-jun	NN	NN	_	16	compound	_	_
16	AP-1	ap-1	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	16	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	activated	activate	VBN	VBN	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	NF-AT	nf-at	NN	NN	_	20	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	Jurkat	jurkat	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	16	nsubj	_	_
9	acutely	acutely	RB	RB	_	10	advmod	_	_
10	exposed	expose	VBN	VBN	_	8	acl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	micromolar	micromolar	JJ	JJ	_	13	amod	_	_
13	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	H2O2	h2o2	NN	NN	_	13	nmod	_	_
16	exhibit	exhibit	VBP	VBP	_	4	ccomp	_	_
17	substantial	substantial	JJ	JJ	_	18	amod	_	_
18	increases	increase	NNS	NNS	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	AP-1	ap-1	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	18	conj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	c-jun	c-jun	NN	NN	_	31	compound	_	_
28	but	but	CC	CC	_	29	cc	_	_
29	not	not	RB	RB	_	27	cc	_	_
30	c-fos	c-fos	NN	NN	_	27	conj	_	_
31	mRNA	mrna	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	preferential	preferential	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	c-jun	c-jun	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	H2O2	h2o2	NN	NN	_	3	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	represent	represent	VB	VB	_	0	root	_	_
11	redox	redox	NN	NN	_	12	compound	_	_
12	stabilization	stabilization	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	transcripts	transcript	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	oxidative	oxidative	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	21	nsubj	_	_
20	closely	closely	RB	RB	_	21	advmod	_	_
21	resembled	resemble	VBD	VBD	_	10	conj	_	_
22	PHA/PMA	pha/pma	NN	NN	_	23	compound	_	_
23	stimulation	stimulation	NN	NN	_	21	xcomp	_	_
24	by	by	IN	IN	_	26	mark	_	_
25	effectively	effectively	RB	RB	_	26	advmod	_	_
26	transactivating	transactivate	VBG	VBG	_	21	advcl	_	_
27	the	the	DT	DT	_	31	det	_	_
28	full	full	JJ	JJ	_	31	amod	_	_
29	length	length	NN	NN	_	31	compound	_	_
30	c-jun	c-jun	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	26	dobj	_	_
32	via	via	IN	IN	_	44	case	_	_
33	the	the	DT	DT	_	44	det	_	_
34	proximal	proximal	JJ	JJ	_	44	amod	_	_
35	jun1	jun1	NN	NN	_	44	compound	_	_
36	tumor	tumor	NN	NN	_	37	nmod:npmod	_	_
37	promoter-responsive	promoter-responsive	JJ	JJ	_	38	amod	_	_
38	element	element	NN	NN	_	42	dep	_	_
39	(	(	-LRB-	-LRB-	_	42	punct	_	_
40	TRE	tre	NN	NN	_	42	nmod:npmod	_	_
41	)	)	-RRB-	-RRB-	_	42	punct	_	_
42	-like	-like	JJ	JJ	_	44	amod	_	_
43	promoter	promoter	NN	NN	_	44	compound	_	_
44	element	element	NN	NN	_	26	nmod	_	_
45	.	.	.	.	_	10	punct	_	_

1	Similarly	similarly	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	complexes	complex	NNS	NNS	_	23	nsubj	_	_
5	binding	bind	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	consensus	consensus	NN	NN	_	9	compound	_	_
8	AP-1	ap-1	NN	NN	_	9	compound	_	_
9	TRE	tre	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	jun	jun	NN	NN	_	13	compound	_	_
12	TRE-like	tre-like	JJ	JJ	_	13	amod	_	_
13	motifs	motif	NNS	NNS	_	9	conj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	exposed	expose	VBN	VBN	_	15	acl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	oxidative	oxidative	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	16	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	PHA/PMA	pha/pma	NN	NN	_	19	conj	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	indistinguishable	indistinguishable	JJ	JJ	_	0	root	_	_
24	,	,	,	,	_	23	punct	_	_
25	being	be	VBG	VBG	_	26	auxpass	_	_
26	composed	compose	VBN	VBN	_	23	xcomp	_	_
27	of	of	IN	IN	_	28	case	_	_
28	c-Fos	c-fos	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	c-Jun	c-jun	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	JunD	jund	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	23	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	PHA/PMA	pha/pma	NN	NN	_	7	compound	_	_
4	but	but	CC	CC	_	3	cc	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	oxidative	oxidative	JJ	JJ	_	3	conj	_	_
7	signals	signal	NNS	NNS	_	8	nsubj	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	coordinate	coordinate	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	constructs	construct	NNS	NNS	_	11	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	the	the	DT	DT	_	24	det	_	_
17	AP-1-TRE	ap-1-tre	NN	NN	_	24	compound	_	_
18	,	,	,	,	_	17	punct	_	_
19	NF-AT	nf-at	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	IL-2	il-2	NN	NN	_	17	conj	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	regions	region	NNS	NNS	_	15	dobj	_	_
25	along	along	IN	IN	_	11	cc	_	_
26	with	with	IN	IN	_	25	dep	_	_
27	IL-2	il-2	NN	NN	_	29	compound	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	11	conj	_	_
30	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	sublethal	sublethal	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	H2O2	h2o2	NN	NN	_	4	nmod	_	_
7	actively	actively	RB	RB	_	8	advmod	_	_
8	suppressed	suppress	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	NF-AT	nf-at	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IL-2	il-2	NN	NN	_	13	conj	_	_
16	reporters	reporter	NNS	NNS	_	11	nmod	_	_
17	as	as	RB	RB	_	11	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	11	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	IL-2	il-2	NN	NN	_	24	compound	_	_
24	mRNA	mrna	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	stimulated	stimulate	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	PHA/PMA	pha/pma	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	oxidative	oxidative	JJ	JJ	_	7	amod	_	_
7	suppression	suppression	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-AT	nf-at	NN	NN	_	7	nmod	_	_
10	represented	represent	VBD	VBD	_	4	ccomp	_	_
11	inhibition	inhibition	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	early	early	JJ	JJ	_	15	amod	_	_
15	generation	generation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	NFAT	nfat	NN	NN	_	18	compound	_	_
18	complexes	complex	NNS	NNS	_	15	nmod	_	_
19	rather	rather	RB	RB	_	15	cc	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	the	the	DT	DT	_	22	det	_	_
22	binding	binding	NN	NN	_	15	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	preformed	preformed	JJ	JJ	_	26	amod	_	_
25	NF-AT	nf-at	NN	NN	_	26	compound	_	_
26	complexes	complex	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	oxidative	oxidative	JJ	JJ	_	6	amod	_	_
6	signals	signal	NNS	NNS	_	11	nsubj	_	_
7	can	can	MD	MD	_	11	aux	_	_
8	positively	positively	RB	RB	_	9	advmod	_	_
9	and	and	CC	CC	_	11	advmod	_	_
10	negatively	negatively	RB	RB	_	9	advmod	_	_
11	regulate	regulate	VB	VB	_	3	ccomp	_	_
12	T	t	NN	NN	_	15	compound	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	events	event	NNS	NNS	_	11	dobj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	changes	change	NNS	NNS	_	23	nsubj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	redox	redox	NN	NN	_	18	nmod	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	uncouple	uncouple	VB	VB	_	11	conj	_	_
24	AP-1	ap-1	NN	NN	_	25	compound	_	_
25	regulation	regulation	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	c-jun	c-jun	NN	NN	_	25	nmod	_	_
28	from	from	IN	IN	_	30	case	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	up-regulation	up-regulation	NN	NN	_	23	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	IL-2	il-2	NN	NN	_	30	nmod	_	_
33	via	via	IN	IN	_	34	case	_	_
34	NF-AT	nf-at	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	tat	tat	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	new	new	JJ	JJ	_	12	amod	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	downregulates	downregulate	VBZ	VBZ	_	3	conj	_	_
15	MIP-1	mip-1	NN	NN	_	17	compound	_	_
16	alpha	alpha	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	activated	activate	VBN	VBN	_	21	amod	_	_
21	T-cells	t-cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	MIP-1	mip-1	NN	NN	_	2	compound	_	_
2	alpha	alpha	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	secreted	secrete	VBN	VBN	_	6	amod	_	_
6	chemokine	chemokine	NN	NN	_	0	root	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	inhibit	inhibit	VB	VB	_	6	acl:relcl	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
11	stem	stem	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	dobj	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	modulate	modulate	VB	VB	_	9	conj	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	responses	response	NNS	NNS	_	14	dobj	_	_
17	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	an	a	DT	DT	_	5	det	_	_
5	inhibitor	inhibitor	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	replication	replication	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	CD8+	cd8+	JJ	JJ	_	11	amod	_	_
11	T-cells	t-cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	MIP-1	mip-1	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	during	during	IN	IN	_	10	case	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD4+	cd4+	JJ	JJ	_	13	amod	_	_
13	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	monocytes	monocyte	NNS	NNS	_	13	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	transformed	transform	VBN	VBN	_	7	amod	_	_
7	B-cells	b-cell	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	new	new	JJ	JJ	_	9	amod	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	4	dobj	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	the	the	DT	DT	_	13	det	_	_
12	MNP	mnp	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	9	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	whose	whose	WP$	WP$	_	16	nmod:poss	_	_
16	expression	expression	NN	NN	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	crucial	crucial	JJ	JJ	_	9	acl:relcl	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	induction	induction	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	MIP-1	mip-1	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	21	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	cellular	cellular	JJ	JJ	_	28	amod	_	_
28	activation	activation	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	in	in	IN	IN	_	33	case	_	_
31	transformed	transform	VBN	VBN	_	33	amod	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	conj	_	_
34	.	.	.	.	_	4	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	transformed	transform	VBN	VBN	_	4	amod	_	_
4	B-cells	b-cell	NNS	NNS	_	1	conj	_	_
5	normally	normally	RB	RB	_	6	advmod	_	_
6	express	express	VBP	VBP	_	0	root	_	_
7	MNP-1	mnp-1	NN	NN	_	6	dobj	_	_
8	strongly	strongly	RB	RB	_	7	advmod	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	MNP-2	mnp-2	NN	NN	_	7	conj	_	_
11	weakly	weakly	RB	RB	_	7	advmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	while	while	IN	IN	_	16	mark	_	_
14	T-cells	t-cell	NNS	NNS	_	16	nsubj	_	_
15	strongly	strongly	RB	RB	_	16	advmod	_	_
16	express	express	VBP	VBP	_	6	advcl	_	_
17	only	only	RB	RB	_	18	advmod	_	_
18	MNP-2	mnp-2	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	reported	report	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	tat	tat	NN	NN	_	8	nsubj	_	_
8	downregulates	downregulate	VBZ	VBZ	_	4	ccomp	_	_
9	MIP-1	mip-1	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	Jurkat	jurkat	NN	NN	_	14	compound	_	_
14	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	induction	induction	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	MNP-1	mnp-1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	T-cells	t-cell	NNS	NNS	_	6	nmod	_	_
12	expressing	express	VBG	VBG	_	11	acl	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	tat	tat	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	neither	neither	CC	CC	_	5	cc:preconj	_	_
4	HTLV-1	htlv-1	NN	NN	_	5	compound	_	_
5	tax	tax	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	T-cells	t-cell	NNS	NNS	_	5	nmod	_	_
9	nor	nor	CC	CC	_	5	cc	_	_
10	EBV	ebv	NN	NN	_	5	conj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	B-cells	b-cell	NNS	NNS	_	10	nmod	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	any	any	DT	DT	_	15	det	_	_
15	effect	effect	NN	NN	_	13	dobj	_	_
16	on	on	IN	IN	_	17	case	_	_
17	MNP-1	mnp-1	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	MNP-2	mnp-2	NN	NN	_	17	conj	_	_
20	expression	expression	NN	NN	_	17	dep	_	_
21	,	,	,	,	_	13	punct	_	_
22	showing	show	VBG	VBG	_	13	advcl	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	effect	effect	NN	NN	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	specific	specific	JJ	JJ	_	22	ccomp	_	_
28	for	for	IN	IN	_	30	case	_	_
29	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
30	tat	tat	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	tat	tat	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
8	MIP-1	mip-1	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	inducing	induce	VBG	VBG	_	7	advcl	_	_
13	MNP-1	mnp-1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	T-cells	t-cell	NNS	NNS	_	14	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	probably	probably	RB	RB	_	12	dep	_	_
19	by	by	IN	IN	_	18	nmod	_	_
20	either	either	CC	CC	_	19	dep	_	_
21	competing	compete	VBG	VBG	_	19	conj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	MNP-2	mnp-2	NN	NN	_	21	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	binding	binding	NN	NN	_	21	nmod	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	MIP-1	mip-1	NN	NN	_	30	compound	_	_
29	alpha	alpha	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	25	nmod	_	_
31	or	or	CC	CC	_	18	cc	_	_
32	by	by	IN	IN	_	33	mark	_	_
33	sequestering	sequester	VBG	VBG	_	18	conj	_	_
34	it	it	PRP	PRP	_	33	dobj	_	_
35	into	into	IN	IN	_	37	case	_	_
36	inactive	inactive	JJ	JJ	_	37	amod	_	_
37	forms	form	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	interferon-alpha	interferon-alpha	NN	NN	_	1	conj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	acquired	acquire	VBN	VBN	_	8	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
8	syndrome	syndrome	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	patients	patient	NNS	NNS	_	10	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	acquired	acquire	VBN	VBN	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	syndrome	syndrome	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	AIDS	aids	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	develop	develop	VBP	VBP	_	0	root	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	resistance	resistance	NN	NN	_	10	dobj	_	_
13	characterized	characterize	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	low	low	JJ	JJ	_	17	amod	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	affinity	affinity	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Kd	kd	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	for	for	IN	IN	_	22	case	_	_
22	glucocorticoids	glucocorticoid	NNS	NNS	_	17	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
25	,	,	,	,	_	26	punct	_	_
26	cells	cell	NNS	NNS	_	17	nmod	_	_
27	and	and	CC	CC	_	17	cc	_	_
28	high	high	JJ	JJ	_	29	amod	_	_
29	values	value	NNS	NNS	_	17	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	ACTH	acth	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	cortisol	cortisol	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	10	punct	_	_

1	As	as	IN	IN	_	3	mark	_	_
2	glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubj	_	_
3	regulate	regulate	VBP	VBP	_	12	advcl	_	_
4	interferon-alpha	interferon-alpha	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	IFN	ifn	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	production	production	NN	NN	_	3	dobj	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	28	mark	_	_
14	IFN	ifn	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	28	nsubjpass	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	18	det	_	_
18	cytokine	cytokine	NN	NN	_	15	appos	_	_
19	produced	produce	VBN	VBN	_	18	acl	_	_
20	predominantly	predominantly	RB	RB	_	22	advmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	AIDS	aids	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	should	should	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	increased	increase	VBN	VBN	_	12	ccomp	_	_
29	in	in	IN	IN	_	31	case	_	_
30	cortisol-resistant	cortisol-resistant	JJ	JJ	_	31	amod	_	_
31	AIDS	aids	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	12	punct	_	_
33	attributing	attribute	VBG	VBG	_	12	xcomp	_	_
34	the	the	DT	DT	_	35	det	_	_
35	lack	lack	NN	NN	_	33	dobj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	cortisol	cortisol	NN	NN	_	38	compound	_	_
38	inhibition	inhibition	NN	NN	_	35	nmod	_	_
39	to	to	TO	TO	_	42	case	_	_
40	IFN	ifn	NN	NN	_	42	compound	_	_
41	alpha	alpha	NN	NN	_	42	compound	_	_
42	production	production	NN	NN	_	33	nmod	_	_
43	.	.	.	.	_	12	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	characteristics	characteristic	NNS	NNS	_	4	dobj	_	_
8	on	on	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	4	nmod	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	measured	measure	VBD	VBD	_	4	conj	_	_
15	IFN	ifn	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	cortisol	cortisol	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	ACTH	acth	NN	NN	_	16	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	AIDS	aids	NN	NN	_	24	compound	_	_
24	patients	patient	NNS	NNS	_	16	nmod	_	_
25	with	with	IN	IN	_	24	acl	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	AIDS-GR	aids-gr	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	or	or	CC	CC	_	24	cc	_	_
30	without	without	IN	IN	_	24	conj	_	_
31	glucocorticoid	glucocorticoid	NN	NN	_	32	compound	_	_
32	resistance	resistance	NN	NN	_	24	dep	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	AIDS-C	aids-c	NN	NN	_	24	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	controls	control	NNS	NNS	_	24	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	C	c	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	4	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	AIDS-GR	aids-gr	NN	NN	_	4	compound	_	_
4	patients	patient	NNS	NNS	_	1	nmod	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	Kd	kd	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	10.5	10.5	CD	CD	_	13	nummod	_	_
11	+/-	+/-	CC	CC	_	10	cc	_	_
12	4.2	4.2	CD	CD	_	10	conj	_	_
13	nmol/L	nmol/l	NN	NN	_	8	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	higher	higher	JJR	JJR	_	8	acl:relcl	_	_
17	than	than	IN	IN	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	AIDS-C	aids-c	NN	NN	_	22	compound	_	_
22	group	group	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	18	punct	_	_
24	2.9	2.9	CD	CD	_	27	nummod	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	0.8	0.8	CD	CD	_	24	conj	_	_
27	nmol/L	nmol/l	NN	NN	_	18	dep	_	_
28	)	)	-RRB-	-RRB-	_	18	punct	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	normal	normal	JJ	JJ	_	31	amod	_	_
31	subjects	subject	NNS	NNS	_	18	conj	_	_
32	(	(	-LRB-	-LRB-	_	31	punct	_	_
33	2.0	2.0	CD	CD	_	36	nummod	_	_
34	+/-	+/-	CC	CC	_	33	cc	_	_
35	0.8	0.8	CD	CD	_	33	conj	_	_
36	nmol/L	nmol/l	NN	NN	_	31	dep	_	_
37	;	;	:	:	_	18	punct	_	_
38	P	p	NN	NN	_	40	dep	_	_
39	&lt;	&lt;	JJR	JJR	_	40	dep	_	_
40	0.01	0.01	CD	CD	_	18	dep	_	_
41	)	)	-RRB-	-RRB-	_	18	punct	_	_
42	.	.	.	.	_	5	punct	_	_

1	IFN	ifn	NN	NN	_	3	compound	_	_
2	alpha	alpha	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	increased	increase	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	AIDS-GR	aids-gr	NN	NN	_	9	compound	_	_
9	group	group	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	35	punct	_	_
11	17	17	CD	CD	_	35	dep	_	_
12	+/-	+/-	CC	CC	_	11	cc	_	_
13	6	6	CD	CD	_	11	conj	_	_
14	vs.	vs.	CC	CC	_	11	cc	_	_
15	4	4	CD	CD	_	18	nummod	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	1	1	CD	CD	_	15	conj	_	_
18	U/mL	u/ml	NN	NN	_	11	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	AIDS-C	aids-c	NN	NN	_	22	compound	_	_
22	group	group	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	2	2	CD	CD	_	27	nummod	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	0.5	0.5	CD	CD	_	24	conj	_	_
27	U/mL	u/ml	NN	NN	_	18	conj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	C	c	NN	NN	_	31	compound	_	_
31	group	group	NN	NN	_	27	nmod	_	_
32	;	;	:	:	_	35	punct	_	_
33	P	p	NN	NN	_	35	dep	_	_
34	&lt;	&lt;	JJR	JJR	_	35	dep	_	_
35	0.01	0.01	CD	CD	_	5	parataxis	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	5	punct	_	_

1	Correlations	correlation	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	between	between	IN	IN	_	7	case	_	_
5	plasma	plasma	NN	NN	_	7	compound	_	_
6	IFN	ifn	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	Kd	kd	NN	NN	_	7	conj	_	_
11	on	on	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	AIDS-GR	aids-gr	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	r	r	NN	NN	_	17	nsubj	_	_
17	=	=	JJ	JJ	_	7	dep	_	_
18	0.77	0.77	CD	CD	_	17	dobj	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	between	between	IN	IN	_	23	case	_	_
22	IFN	ifn	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	7	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	plasma	plasma	NN	NN	_	26	compound	_	_
26	cortisol	cortisol	NN	NN	_	23	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	same	same	JJ	JJ	_	30	amod	_	_
30	group	group	NN	NN	_	23	nmod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	r	r	NN	NN	_	33	nsubj	_	_
33	=	=	JJ	JJ	_	23	dep	_	_
34	0.74	0.74	CD	CD	_	33	dobj	_	_
35	)	)	-RRB-	-RRB-	_	33	punct	_	_
36	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	poly(I)-poly(C)-induced	poly(i)-poly(c)-induced	JJ	JJ	_	5	amod	_	_
3	IFN	ifn	NN	NN	_	5	compound	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	9	nsubj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	aux	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	C	c	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	AIDS-C	aids-c	NN	NN	_	14	conj	_	_
17	groups	group	NNS	NNS	_	9	nmod	_	_
18	(	(	-LRB-	-LRB-	_	9	punct	_	_
19	approximately	approximately	RB	RB	_	20	advmod	_	_
20	80	80	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	9	dobj	_	_
22	inhibition	inhibition	NN	NN	_	21	dep	_	_
23	in	in	IN	IN	_	25	case	_	_
24	both	both	DT	DT	_	25	det	_	_
25	groups	group	NNS	NNS	_	21	nmod	_	_
26	)	)	-RRB-	-RRB-	_	9	punct	_	_
27	;	;	:	:	_	9	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	effect	effect	NN	NN	_	31	nsubjpass	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	reversed	reverse	VBN	VBN	_	9	parataxis	_	_
32	by	by	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	receptor	receptor	NN	NN	_	36	compound	_	_
35	antagonist	antagonist	NN	NN	_	36	compound	_	_
36	RU-38486	ru-38486	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	31	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	5	nsubj	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	inhibit	inhibit	VB	VB	_	5	xcomp	_	_
8	IFNalpha	ifnalpha	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	from	from	IN	IN	_	12	case	_	_
11	AIDS-GR	aids-gr	NN	NN	_	12	compound	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	7	punct	_	_
14	approximately	approximately	RB	RB	_	15	advmod	_	_
15	20	20	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	7	dobj	_	_
17	inhibition	inhibition	NN	NN	_	16	dep	_	_
18	)	)	-RRB-	-RRB-	_	7	punct	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	elevated	elevated	JJ	JJ	_	7	amod	_	_
5	IFN	ifn	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	15	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	AIDS-GR	aids-gr	NN	NN	_	7	nmod	_	_
10	may	may	MD	MD	_	15	aux	_	_
11	be	be	VB	VB	_	15	cop	_	_
12	due	due	JJ	JJ	_	15	case	_	_
13	to	to	TO	TO	_	12	mwe	_	_
14	the	the	DT	DT	_	15	det	_	_
15	lack	lack	NN	NN	_	0	root	_	_
16	of	of	IN	IN	_	18	case	_	_
17	inhibitory	inhibitory	JJ	JJ	_	18	amod	_	_
18	effect	effect	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cortisol	cortisol	NN	NN	_	18	nmod	_	_
21	on	on	IN	IN	_	24	case	_	_
22	IFN	ifn	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	production	production	NN	NN	_	18	nmod	_	_
25	due	due	IN	IN	_	28	case	_	_
26	to	to	TO	TO	_	25	mwe	_	_
27	cortisol	cortisol	JJ	JJ	_	28	amod	_	_
28	resistance	resistance	NN	NN	_	15	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	monocytes	monocyte	NNS	NNS	_	28	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	Mapping	mapping	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
5	repression	repression	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	lymphoid-specific	lymphoid-specific	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	oct-2A	oct-2a	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	lymphoid-specific	lymphoid-specific	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	7	nsubjpass	_	_
5	Oct-2a	oct-2a	NN	NN	_	4	dep	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	implicated	implicate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	B	b	NN	NN	_	10	nmod:npmod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	10	dep	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	via	via	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	octamer	octamer	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Structure/function	structure/function	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	various	various	JJ	JJ	_	7	amod	_	_
5	Oct-2a	oct-2a	NN	NN	_	7	compound	_	_
6	effector	effector	NN	NN	_	7	compound	_	_
7	regions	region	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	context	context	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	GAL4	gal4	NN	NN	_	15	compound	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	domain	domain	NN	NN	_	10	nmod	_	_
16	revealed	reveal	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	19	mark	_	_
18	Oct-2a	oct-2a	NN	NN	_	19	nsubj	_	_
19	contains	contain	VBZ	VBZ	_	16	ccomp	_	_
20	two	two	CD	CD	_	24	nummod	_	_
21	functionally	functionally	RB	RB	_	22	advmod	_	_
22	different	different	JJ	JJ	_	24	amod	_	_
23	activation	activation	NN	NN	_	24	compound	_	_
24	domains	domain	NNS	NNS	_	19	dobj	_	_
25	at	at	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	N	n	NN	NN	_	19	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	C	c	NN	NN	_	27	conj	_	_
31	termini	terminus	NNS	NNS	_	27	dep	_	_
32	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	both	both	DT	DT	_	6	det	_	_
6	domains	domain	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	strongly	strongly	RB	RB	_	9	advmod	_	_
9	potentiated	potentiate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	interactions	interaction	NNS	NNS	_	9	nmod	_	_
12	with	with	IN	IN	_	16	case	_	_
13	distinct	distinct	JJ	JJ	_	16	amod	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell-specific	cell-specific	JJ	JJ	_	16	amod	_	_
16	coactivators	coactivator	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	repression	repression	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	5	dobj	_	_
9	located	located	JJ	JJ	_	8	amod	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	N	n	NN	NN	_	13	compound	_	_
13	terminus	terminus	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Oct-2a	oct-2a	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	amino	amino	NN	NN	_	18	compound	_	_
18	acids	acid	NNS	NNS	_	13	appos	_	_
19	2-99	2-99	CD	CD	_	18	nummod	_	_
20	)	)	-RRB-	-RRB-	_	18	punct	_	_
21	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	this	this	DT	DT	_	3	det	_	_
3	domain	domain	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	transferred	transfer	VBN	VBN	_	14	advcl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	potent	potent	JJ	JJ	_	9	amod	_	_
9	activator	activator	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	transcription	transcription	NN	NN	_	14	nsubjpass	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	strongly	strongly	RB	RB	_	14	advmod	_	_
14	inhibited	inhibit	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	present	present	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	deletion	deletion	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	N-terminal	n-terminal	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Oct-2a	oct-2a	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	determine	determine	VB	VB	_	5	advcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	minimal	minimal	JJ	JJ	_	20	amod	_	_
19	repression	repression	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	stretch	stretch	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	23	23	CD	CD	_	8	nummod	_	_
7	amino	amino	NN	NN	_	8	compound	_	_
8	acids	acid	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	rich	rich	JJ	JJ	_	4	amod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	serine	serine	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	threonine	threonine	NN	NN	_	12	conj	_	_
15	residues	residue	NNS	NNS	_	12	dep	_	_
16	,	,	,	,	_	4	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	responsible	responsible	JJ	JJ	_	4	acl:relcl	_	_
20	for	for	IN	IN	_	21	case	_	_
21	most	most	JJS	JJS	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	repression	repression	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	repression	repression	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	strongly	strongly	RB	RB	_	7	advmod	_	_
7	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	type	type	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	enhancer	enhancer	NN	NN	_	10	nmod	_	_
13	present	present	JJ	JJ	_	12	amod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	plasmid	plasmid	NN	NN	_	13	nmod	_	_
18	as	as	RB	RB	_	10	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	on	on	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	10	conj	_	_
25	tested	test	VBN	VBN	_	24	acl	_	_
26	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	possibility	possibility	NN	NN	_	14	nsubj	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	Oct-2a	oct-2a	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	act	act	VB	VB	_	2	ccomp	_	_
7	as	as	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	activator	activator	NN	NN	_	6	nmod	_	_
10	and/or	and/or	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	repressor	repressor	NN	NN	_	9	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	have	have	VB	VB	_	0	root	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	consequences	consequence	NNS	NNS	_	14	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	function	function	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Oct-2a	oct-2a	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	differentiation	differentiation	NN	NN	_	19	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	other	other	JJ	JJ	_	29	amod	_	_
28	developmental	developmental	JJ	JJ	_	29	amod	_	_
29	processes	process	NNS	NNS	_	25	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	Receptors	receptor	NNS	NNS	_	11	nsubj	_	_
2	for	for	IN	IN	_	5	case	_	_
3	interleukin	interleukin	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL	il	NN	NN	_	1	nmod	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-10	-10	CD	CD	_	5	nummod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	IL-6-type	il-6-type	JJ	JJ	_	5	conj	_	_
10	cytokines	cytokine	NNS	NNS	_	5	dep	_	_
11	use	use	VBP	VBP	_	0	root	_	_
12	similar	similar	JJ	JJ	_	14	amod	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	mechanisms	mechanism	NNS	NNS	_	11	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	inducing	inducing	NN	NN	_	11	advcl	_	_
17	transcription	transcription	NN	NN	_	16	dobj	_	_
18	through	through	IN	IN	_	21	case	_	_
19	IL-6	il-6	NN	NN	_	21	compound	_	_
20	response	response	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytoplasmic	cytoplasmic	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	receptor	receptor	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	8	case	_	_
8	interleukin	interleukin	NN	NN	_	6	nmod	_	_
9	10	10	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-10R	il-10r	NN	NN	_	6	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	contains	contain	VBZ	VBZ	_	0	root	_	_
14	two	two	CD	CD	_	18	nummod	_	_
15	box	box	NN	NN	_	18	compound	_	_
16	3	3	CD	CD	_	18	nummod	_	_
17	sequence	sequence	NN	NN	_	18	compound	_	_
18	motifs	motif	NNS	NNS	_	13	dobj	_	_
19	that	that	WDT	WDT	_	22	nsubjpass	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	identified	identify	VBN	VBN	_	18	acl:relcl	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	signal-transducing	signal-transducing	JJ	JJ	_	27	amod	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	subunits	subunit	NNS	NNS	_	22	nmod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	IL-6-type	il-6-type	JJ	JJ	_	30	amod	_	_
30	cytokines	cytokine	NNS	NNS	_	27	nmod	_	_
31	and	and	CC	CC	_	22	cc	_	_
32	noted	note	VBN	VBN	_	22	conj	_	_
33	to	to	TO	TO	_	35	mark	_	_
34	be	be	VB	VB	_	35	auxpass	_	_
35	required	require	VBN	VBN	_	32	xcomp	_	_
36	for	for	IN	IN	_	37	mark	_	_
37	activating	activate	VBG	VBG	_	35	advcl	_	_
38	STAT3	stat3	NN	NN	_	37	dobj	_	_
39	and	and	CC	CC	_	37	cc	_	_
40	inducing	induce	VBG	VBG	_	37	conj	_	_
41	transcription	transcription	NN	NN	_	40	dobj	_	_
42	through	through	IN	IN	_	44	case	_	_
43	IL-6-responsive	il-6-responsive	JJ	JJ	_	44	amod	_	_
44	elements	element	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	IL-10R	il-10r	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	2	ccomp	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	functions	function	NNS	NNS	_	6	dobj	_	_
9	similar	similar	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	IL-6R	il-6r	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	normally	normally	RB	RB	_	15	advmod	_	_
15	expressing	express	VBG	VBG	_	13	acl	_	_
16	these	these	DT	DT	_	17	det	_	_
17	receptors	receptor	NNS	NNS	_	15	dobj	_	_
18	,	,	,	,	_	2	punct	_	_
19	leukocytes	leukocyte	NNS	NNS	_	30	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	B-	b-	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	T-	t-	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	NK-cell	nk-cell	NN	NN	_	22	conj	_	_
28	lineages	lineage	NNS	NNS	_	22	dep	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	treated	treat	VBN	VBN	_	2	parataxis	_	_
31	with	with	IN	IN	_	33	case	_	_
32	either	either	DT	DT	_	33	det	_	_
33	cytokine	cytokine	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	dep	_	_
2	cytokines	cytokine	NNS	NNS	_	3	nsubj	_	_
3	activated	activate	VBD	VBD	_	0	root	_	_
4	factors	factor	NNS	NNS	_	3	dobj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	bound	bind	VBD	VBD	_	4	acl:relcl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	sis-inducible	sis-inducible	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	included	include	VBD	VBD	_	6	conj	_	_
13	STAT1	stat1	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	STAT3	stat3	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	response	response	NN	NN	_	7	nsubj	_	_
4	to	to	TO	TO	_	5	case	_	_
5	IL-10	il-10	NN	NN	_	3	nmod	_	_
6	characteristically	characteristically	RB	RB	_	7	advmod	_	_
7	differed	differ	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	that	that	DT	DT	_	7	nmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	IL-2/IL-15	il-2/il-15	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	IL-4	il-4	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	interferon	interferon	NN	NN	_	17	compound	_	_
17	gamma	gamma	NN	NN	_	11	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	signaling	signaling	NN	NN	_	3	compound	_	_
3	capabilities	capability	NNS	NNS	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	IL-10R	il-10r	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	8	mark	_	_
8	activating	activate	VBG	VBG	_	3	acl	_	_
9	specific	specific	JJ	JJ	_	11	amod	_	_
10	STAT	stat	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	inducing	induce	VBG	VBG	_	8	conj	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	defined	define	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	case	_	_
19	reconstitution	reconstitution	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	functions	function	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	transfected	transfect	VBN	VBN	_	27	amod	_	_
25	tissue	tissue	NN	NN	_	27	compound	_	_
26	culture	culture	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	COS-1	cos-1	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	13	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	co-expressing	co-express	VBG	VBG	_	2	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	IL-10R	il-10r	NN	NN	_	4	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	individual	individual	JJ	JJ	_	11	amod	_	_
10	STAT	stat	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	7	conj	_	_
12	,	,	,	,	_	2	punct	_	_
13	confirmed	confirm	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	preference	preference	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	IL-10R	il-10r	NN	NN	_	15	nmod	_	_
19	for	for	IN	IN	_	20	case	_	_
20	STAT3	stat3	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	STAT1	stat1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	13	punct	_	_

1	Unlike	unlike	IN	IN	_	4	case	_	_
2	many	many	JJ	JJ	_	4	amod	_	_
3	hematopoietin	hematopoietin	NN	NN	_	4	compound	_	_
4	receptors	receptor	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	IL-10R	il-10r	NN	NN	_	11	nsubj	_	_
8	did	do	VBD	VBD	_	11	aux	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	detectably	detectably	RB	RB	_	11	advmod	_	_
11	activate	activate	VB	VB	_	0	root	_	_
12	STAT5	stat5	NN	NN	_	11	dobj	_	_
13	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	IL-10R	il-10r	NN	NN	_	15	nsubj	_	_
3	,	,	,	,	_	15	punct	_	_
4	together	together	RB	RB	_	8	advmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	reporter	reporter	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	15	nmod	_	_
9	containing	contain	VBG	VBG	_	8	acl	_	_
10	different	different	JJ	JJ	_	13	amod	_	_
11	IL-6-responsive	il-6-responsive	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	9	dobj	_	_
14	,	,	,	,	_	15	punct	_	_
15	reconstituted	reconstitute	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	hepatoma	hepatoma	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	an	a	DT	DT	_	20	det	_	_
20	induction	induction	NN	NN	_	15	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	IL-10	il-10	NN	NN	_	20	nmod	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	comparable	comparable	JJ	JJ	_	20	acl:relcl	_	_
28	to	to	TO	TO	_	29	case	_	_
29	that	that	DT	DT	_	27	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	IL-6	il-6	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	7	nsubjpass	_	_
3	could	could	MD	MD	_	7	aux	_	_
4	not	not	RB	RB	_	7	neg	_	_
5	be	be	VB	VB	_	7	auxpass	_	_
6	appreciably	appreciably	RB	RB	_	7	advmod	_	_
7	modified	modify	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	enhanced	enhance	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	STAT	stat	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	actions	action	NNS	NNS	_	16	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-10R	il-10r	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-6R	il-6r	NN	NN	_	5	conj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	endogenous	endogenous	JJ	JJ	_	14	amod	_	_
13	IL-6-responsive	il-6-responsive	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	hepatoma	hepatoma	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	stably	stably	RB	RB	_	21	advmod	_	_
21	expressing	express	VBG	VBG	_	19	acl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	IL-10R	il-10r	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	functions	function	NNS	NNS	_	4	nsubj	_	_
4	required	require	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	box	box	NN	NN	_	11	compound	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	motifs	motif	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	shown	show	VBN	VBN	_	4	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	analysis	analysis	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	mouse	mouse	NN	NN	_	22	compound	_	_
21	IL-10R	il-10r	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	17	nmod	_	_
23	containing	contain	VBG	VBG	_	22	acl	_	_
24	progressively	progressively	RB	RB	_	27	advmod	_	_
25	truncated	truncate	VBN	VBN	_	27	amod	_	_
26	cytoplasmic	cytoplasmic	JJ	JJ	_	27	amod	_	_
27	domains	domain	NNS	NNS	_	23	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	IL-10R	il-10r	NN	NN	_	19	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	unlike	unlike	IN	IN	_	10	case	_	_
9	other	other	JJ	JJ	_	10	amod	_	_
10	members	member	NNS	NNS	_	19	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	interferon	interferon	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	highly	highly	RB	RB	_	19	advmod	_	_
19	effective	effective	JJ	JJ	_	3	ccomp	_	_
20	in	in	IN	IN	_	21	mark	_	_
21	recruiting	recruit	VBG	VBG	_	19	advcl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathways	pathway	NNS	NNS	_	21	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	IL-6-type	il-6-type	JJ	JJ	_	28	amod	_	_
27	cytokine	cytokine	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Cooperation	cooperation	NN	NN	_	10	nsubj	_	_
2	between	between	IN	IN	_	5	case	_	_
3	core	core	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	adjacent	adjacent	JJ	JJ	_	9	amod	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	5	conj	_	_
10	contributes	contribute	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	interleukin-3	interleukin-3	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Tissue-specific	tissue-specific	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin-3	interleukin-3	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IL-3	il-3	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	0	root	_	_
10	via	via	IN	IN	_	12	case	_	_
11	cis-acting	cis-acting	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	9	nmod	_	_
13	located	located	JJ	JJ	_	12	amod	_	_
14	within	within	IN	IN	_	17	case	_	_
15	315	315	CD	CD	_	17	nummod	_	_
16	base	base	NN	NN	_	17	compound	_	_
17	pairs	pair	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	start	start	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	achieved	achieve	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	part	part	NN	NN	_	9	nmod	_	_
6	through	through	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	positive	positive	JJ	JJ	_	9	amod	_	_
9	activities	activity	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	AP-1	ap-1	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Elf-1	elf-1	NN	NN	_	12	conj	_	_
15	sites	site	NNS	NNS	_	9	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-3	il-3	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	contribution	contribution	NN	NN	_	12	nsubjpass	_	_
3	to	to	TO	TO	_	6	case	_	_
4	T	t	NN	NN	_	5	nmod:npmod	_	_
5	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	other	other	JJ	JJ	_	10	amod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	assessed	assess	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	transient	transient	JJ	JJ	_	17	amod	_	_
16	expression	expression	NN	NN	_	17	compound	_	_
17	assay	assay	NN	NN	_	12	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	IL-3	il-3	NN	NN	_	21	compound	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	constructs	construct	NNS	NNS	_	17	nmod	_	_
22	linked	link	VBN	VBN	_	21	acl	_	_
23	to	to	TO	TO	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	luciferase	luciferase	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	12	punct	_	_
28	focusing	focus	VBG	VBG	_	12	xcomp	_	_
29	initially	initially	RB	RB	_	28	advmod	_	_
30	on	on	IN	IN	_	38	case	_	_
31	the	the	DT	DT	_	38	det	_	_
32	core	core	NN	NN	_	34	compound	_	_
33	binding	binding	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	CBF	cbf	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	site	site	NN	NN	_	28	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	which	which	WDT	WDT	_	42	nsubj	_	_
41	is	be	VBZ	VBZ	_	42	aux	_	_
42	footprinted	footprinted	JJ	JJ	_	38	acl:relcl	_	_
43	in	in	FW	FW	_	44	compound	_	_
44	vivo	vivo	FW	FW	_	42	advmod	_	_
45	upon	upon	IN	IN	_	48	case	_	_
46	T	t	NN	NN	_	48	compound	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	activation	activation	NN	NN	_	42	nmod	_	_
49	.	.	.	.	_	12	punct	_	_

1	Activity	activity	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CBF	cbf	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	11	mark	_	_
9	be	be	VB	VB	_	11	cop	_	_
10	critically	critically	RB	RB	_	11	advmod	_	_
11	dependent	dependent	JJ	JJ	_	7	xcomp	_	_
12	on	on	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	adjacent	adjacent	JJ	JJ	_	16	amod	_	_
15	activator	activator	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	Act-1	act-1	CD	CD	_	16	nummod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Together	together	RB	RB	_	7	advmod	_	_
2	the	the	DT	DT	_	6	det	_	_
3	Act-1	act-1	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	CBF	cbf	NN	NN	_	3	conj	_	_
6	sites	site	NNS	NNS	_	7	nsubj	_	_
7	form	form	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	unit	unit	NN	NN	_	7	dobj	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	AC	ac	NN	NN	_	13	compound	_	_
13	unit	unit	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	with	with	IN	IN	_	17	case	_	_
16	dual	dual	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	AC	ac	NN	NN	_	3	compound	_	_
3	unit	unit	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	5	xcomp	_	_
7	enhance	enhance	VB	VB	_	9	dep	_	_
8	basal	basal	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	promoters	promoter	NNS	NNS	_	9	nmod	_	_
12	both	both	CC	CC	_	14	advmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	inducible	inducible	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	9	cc	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	in	in	IN	IN	_	14	case	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	9	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	9	case	_	_
2	addition	addition	NN	NN	_	9	dep	_	_
3	to	to	TO	TO	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	already	already	RB	RB	_	6	advmod	_	_
6	identified	identify	VBN	VBN	_	9	amod	_	_
7	NIP	nip	NN	NN	_	9	compound	_	_
8	repressor	repressor	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	13	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	evidence	evidence	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	presented	present	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	second	second	JJ	JJ	_	18	amod	_	_
17	repressor	repressor	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	13	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	restricts	restrict	VBZ	VBZ	_	18	acl:relcl	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	fibroblasts	fibroblast	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	novel	novel	JJ	JJ	_	7	amod	_	_
5	positive	positive	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	10	nsubjpass	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	mapped	map	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IL-3	il-3	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	between	between	IN	IN	_	16	case	_	_
16	nucleotide	nucleotide	NN	NN	_	14	nmod	_	_
17	-180	-180	CD	CD	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	-210	-210	CD	CD	_	17	conj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	leads	lead	VBZ	VBZ	_	14	acl:relcl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	increased	increase	VBN	VBN	_	24	amod	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	Together	together	RB	RB	_	4	advmod	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	13	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IL-3	il-3	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	specified	specify	VBN	VBN	_	4	ccomp	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	single	single	JJ	JJ	_	21	amod	_	_
20	tissue-specific	tissue-specific	JJ	JJ	_	21	amod	_	_
21	element	element	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	but	but	CC	CC	_	13	cc	_	_
24	instead	instead	RB	RB	_	13	advmod	_	_
25	involves	involve	VBZ	VBZ	_	13	dep	_	_
26	multiple	multiple	JJ	JJ	_	28	amod	_	_
27	interacting	interact	VBG	VBG	_	28	amod	_	_
28	elements	element	NNS	NNS	_	25	dobj	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	provide	provide	VBP	VBP	_	28	acl:relcl	_	_
31	both	both	CC	CC	_	34	cc:preconj	_	_
32	specific	specific	JJ	JJ	_	34	amod	_	_
33	positive	positive	JJ	JJ	_	34	amod	_	_
34	regulation	regulation	NN	NN	_	30	dobj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	specific	specific	JJ	JJ	_	41	amod	_	_
40	negative	negative	JJ	JJ	_	41	amod	_	_
41	regulation	regulation	NN	NN	_	34	conj	_	_
42	in	in	IN	IN	_	43	case	_	_
43	fibroblasts	fibroblast	NNS	NNS	_	41	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	Globin	globin	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	switching	switching	NN	NN	_	0	root	_	_
4	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
4	interactions	interaction	NNS	NNS	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	beta-globin	beta-globin	NN	NN	_	9	compound	_	_
9	locus	locus	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	expressing	express	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	fetal	fetal	JJ	JJ	_	13	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	adult	adult	JJ	JJ	_	15	conj	_	_
19	globin	globin	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	program	program	NN	NN	_	15	dep	_	_
22	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	protein-DNA	protein-dna	JJ	JJ	_	5	amod	_	_
5	interactions	interaction	NNS	NNS	_	2	dobj	_	_
6	important	important	JJ	JJ	_	5	amod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	developmental	developmental	JJ	JJ	_	10	amod	_	_
10	control	control	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	beta-globin	beta-globin	NN	NN	_	15	compound	_	_
15	locus	locus	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	analyzed	analyze	VBD	VBD	_	2	parataxis	_	_
19	by	by	IN	IN	_	24	case	_	_
20	in	in	FW	FW	_	24	amod	_	_
21	vivo	vivo	FW	FW	_	20	dep	_	_
22	dimethyl	dimethyl	NN	NN	_	24	compound	_	_
23	sulfate	sulfate	JJ	JJ	_	24	amod	_	_
24	footprinting	footprinting	NN	NN	_	18	nmod	_	_
25	erythroid	erythroid	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	18	dobj	_	_
27	expressing	express	VBG	VBG	_	26	acl	_	_
28	either	either	CC	CC	_	30	cc:preconj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	fetal	fetal	JJ	JJ	_	27	dobj	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	adult	adult	JJ	JJ	_	30	conj	_	_
34	globin	globin	NN	NN	_	36	compound	_	_
35	developmental	developmental	JJ	JJ	_	36	amod	_	_
36	program	program	NN	NN	_	30	dep	_	_
37	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	locus	locus	NN	NN	_	5	compound	_	_
4	control	control	NN	NN	_	5	compound	_	_
5	region	region	NN	NN	_	26	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LCR	lcr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	beta-globin	beta-globin	NN	NN	_	12	compound	_	_
12	locus	locus	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	26	punct	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	vivo	vivo	FW	FW	_	14	dep	_	_
16	footprints	footprint	NNS	NNS	_	26	nsubj	_	_
17	on	on	IN	IN	_	18	case	_	_
18	NF-E2	nf-e2	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	or	or	CC	CC	_	21	cc	_	_
21	AP-1	ap-1	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	GATA-1	gata-1	NN	NN	_	25	compound	_	_
25	motifs	motif	NNS	NNS	_	18	conj	_	_
26	remained	remain	VBD	VBD	_	0	root	_	_
27	the	the	DT	DT	_	28	det	_	_
28	same	same	JJ	JJ	_	26	xcomp	_	_
29	regardless	regardless	RB	RB	_	26	advmod	_	_
30	of	of	IN	IN	_	40	mark	_	_
31	whether	whether	IN	IN	_	40	mark	_	_
32	the	the	DT	DT	_	33	det	_	_
33	fetal	fetal	JJ	JJ	_	40	nsubjpass	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	the	the	DT	DT	_	38	det	_	_
36	adult	adult	JJ	JJ	_	38	amod	_	_
37	globin	globin	NN	NN	_	38	compound	_	_
38	genes	gene	NNS	NNS	_	33	conj	_	_
39	are	be	VBP	VBP	_	40	auxpass	_	_
40	expressed	express	VBN	VBN	_	29	advcl	_	_
41	.	.	.	.	_	26	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	footprints	footprint	NNS	NNS	_	13	nsubj	_	_
7	on	on	IN	IN	_	12	case	_	_
8	GT	gt	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	CACCC	caccc	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	motifs	motif	NNS	NNS	_	6	nmod	_	_
13	differed	differ	VBD	VBD	_	0	root	_	_
14	between	between	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	expressing	express	VBG	VBG	_	16	acl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	fetal	fetal	JJ	JJ	_	17	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	adult	adult	JJ	JJ	_	19	conj	_	_
23	globin	globin	NN	NN	_	24	compound	_	_
24	program	program	NN	NN	_	19	dep	_	_
25	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	regions	region	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	actively	actively	RB	RB	_	8	advmod	_	_
7	transcribed	transcribe	VBN	VBN	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	9	nsubj	_	_
9	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
10	extensive	extensive	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	consistent	consistent	JJ	JJ	_	10	conj	_	_
13	footprints	footprint	NNS	NNS	_	9	dobj	_	_
14	over	over	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	canonical	canonical	JJ	JJ	_	17	amod	_	_
17	elements	element	NNS	NNS	_	9	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	such	such	JJ	JJ	_	21	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	CACCC	caccc	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	CCAAT	ccaat	NN	NN	_	21	conj	_	_
24	motifs	motif	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	adult	adult	JJ	JJ	_	5	amod	_	_
3	globin	globin	NN	NN	_	5	compound	_	_
4	expressing	expressing	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	displayed	display	VBD	VBD	_	0	root	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	extensive	extensive	JJ	JJ	_	9	amod	_	_
9	footprints	footprint	NNS	NNS	_	6	dobj	_	_
10	than	than	IN	IN	_	15	mark	_	_
11	the	the	DT	DT	_	15	det	_	_
12	fetal	fetal	JJ	JJ	_	15	amod	_	_
13	globin	globin	NN	NN	_	15	compound	_	_
14	expressing	expressing	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	dep	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	3'	3'	JJ	JJ	_	20	amod	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	sequences	sequence	NNS	NNS	_	6	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	the	the	DT	DT	_	24	det	_	_
24	Agamma-	agamma-	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	27	det	_	_
27	beta-globin	beta-globin	NN	NN	_	24	conj	_	_
28	genes	gene	NNS	NNS	_	24	dep	_	_
29	,	,	,	,	_	6	punct	_	_
30	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
31	a	a	DT	DT	_	32	det	_	_
32	role	role	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	these	these	DT	DT	_	36	det	_	_
35	3'	3'	JJ	JJ	_	36	amod	_	_
36	elements	element	NNS	NNS	_	32	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	beta-globin	beta-globin	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	32	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	bulk	bulk	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	protein-DNA	protein-dna	JJ	JJ	_	9	amod	_	_
9	interactions	interaction	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	underlies	underlie	VBZ	VBZ	_	6	acl:relcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	developmental	developmental	JJ	JJ	_	14	amod	_	_
14	control	control	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	globin	globin	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	takes	take	VBZ	VBZ	_	3	ccomp	_	_
19	place	place	NN	NN	_	18	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	gamma-	gamma-	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	beta-globin	beta-globin	NN	NN	_	22	conj	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	promoters	promoter	NNS	NNS	_	22	dep	_	_
27	,	,	,	,	_	18	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	that	that	IN	IN	_	38	mark	_	_
30	GT	gt	NN	NN	_	31	compound	_	_
31	motifs	motif	NNS	NNS	_	38	nsubj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	beta-globin	beta-globin	NN	NN	_	35	compound	_	_
35	locus	locus	NN	NN	_	31	nmod	_	_
36	LCR	lcr	NN	NN	_	35	dep	_	_
37	may	may	MD	MD	_	38	aux	_	_
38	play	play	VB	VB	_	18	conj	_	_
39	a	a	DT	DT	_	40	det	_	_
40	role	role	NN	NN	_	38	dobj	_	_
41	in	in	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	developmental	developmental	JJ	JJ	_	44	amod	_	_
44	regulation	regulation	NN	NN	_	38	nmod	_	_
45	of	of	IN	IN	_	49	case	_	_
46	human	human	JJ	JJ	_	49	amod	_	_
47	beta-globin	beta-globin	NN	NN	_	48	compound	_	_
48	gene	gene	NN	NN	_	49	compound	_	_
49	expression	expression	NN	NN	_	44	nmod	_	_
50	,	,	,	,	_	38	punct	_	_
51	perhaps	perhaps	RB	RB	_	53	advmod	_	_
52	by	by	IN	IN	_	53	mark	_	_
53	increasing	increase	VBG	VBG	_	38	advcl	_	_
54	the	the	DT	DT	_	55	det	_	_
55	probability	probability	NN	NN	_	53	dobj	_	_
56	of	of	IN	IN	_	57	case	_	_
57	interaction	interaction	NN	NN	_	55	nmod	_	_
58	of	of	IN	IN	_	61	case	_	_
59	the	the	DT	DT	_	61	det	_	_
60	LCR	lcr	NN	NN	_	61	compound	_	_
61	holocomplex	holocomplex	NN	NN	_	57	nmod	_	_
62	with	with	IN	IN	_	64	case	_	_
63	the	the	DT	DT	_	64	det	_	_
64	fetal	fetal	JJ	JJ	_	57	nmod	_	_
65	or	or	CC	CC	_	64	cc	_	_
66	the	the	DT	DT	_	67	det	_	_
67	adult	adult	JJ	JJ	_	64	conj	_	_
68	globin	globin	NN	NN	_	69	compound	_	_
69	gene	gene	NN	NN	_	64	dep	_	_
70	.	.	.	.	_	3	punct	_	_

1	Tissue-specific	tissue-specific	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	gammac	gammac	NN	NN	_	8	compound	_	_
6	chain	chain	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	2	nmod	_	_
9	depends	depend	VBZ	VBZ	_	0	root	_	_
10	upon	upon	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	Ets	ets	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	regulated	regulate	VBN	VBN	_	9	conj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	GA-binding	ga-binding	JJ	JJ	_	20	amod	_	_
20	protein	protein	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	gammac	gammac	NN	NN	_	3	compound	_	_
3	chain	chain	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subunit	subunit	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	multiple	multiple	JJ	JJ	_	10	amod	_	_
9	cytokine	cytokine	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	interleukin	interleukin	NN	NN	_	14	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IL	il	NN	NN	_	10	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	-2	-2	CD	CD	_	14	nummod	_	_
17	,	,	,	,	_	14	punct	_	_
18	IL-4	il-4	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	IL-7	il-7	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	IL-9	il-9	NN	NN	_	14	conj	_	_
23	,	,	,	,	_	14	punct	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	IL-15	il-15	NN	NN	_	14	conj	_	_
26	)	)	-RRB-	-RRB-	_	14	punct	_	_
27	,	,	,	,	_	6	punct	_	_
28	the	the	DT	DT	_	29	det	_	_
29	expression	expression	NN	NN	_	33	nsubj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	which	which	WDT	WDT	_	29	nmod	_	_
32	is	be	VBZ	VBZ	_	33	cop	_	_
33	restricted	restricted	JJ	JJ	_	6	acl:relcl	_	_
34	to	to	TO	TO	_	36	case	_	_
35	hematopoietic	hematopoietic	JJ	JJ	_	36	amod	_	_
36	lineages	lineage	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	defect	defect	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	gammac	gammac	NN	NN	_	2	nmod	_	_
5	leads	lead	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	X-linked	x-linked	JJ	JJ	_	11	amod	_	_
9	severe	severe	JJ	JJ	_	8	dep	_	_
10	combined	combined	JJ	JJ	_	8	dep	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	5	nmod	_	_
12	characterized	characterize	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	block	block	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	5	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	5	mark	_	_
4	better	better	RB	RB	_	5	advmod	_	_
5	characterize	characterize	VB	VB	_	36	advcl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	gammac	gammac	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	define	define	VB	VB	_	5	conj	_	_
12	the	the	DT	DT	_	16	det	_	_
13	minimal	minimal	JJ	JJ	_	16	amod	_	_
14	tissue-specific	tissue-specific	JJ	JJ	_	16	amod	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	11	dobj	_	_
17	,	,	,	,	_	36	punct	_	_
18	progressive	progressive	JJ	JJ	_	20	amod	_	_
19	5'-deletion	5'-deletion	JJ	JJ	_	20	amod	_	_
20	constructs	construct	NNS	NNS	_	36	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	segment	segment	NN	NN	_	20	nmod	_	_
24	extending	extend	VBG	VBG	_	23	acl	_	_
25	1053	1053	CD	CD	_	27	nummod	_	_
26	base	base	NN	NN	_	27	compound	_	_
27	pairs	pair	NNS	NNS	_	24	dobj	_	_
28	upstream	upstream	RB	RB	_	27	advmod	_	_
29	of	of	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	major	major	JJ	JJ	_	34	amod	_	_
32	transcription	transcription	NN	NN	_	34	compound	_	_
33	start	start	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	27	nmod	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	generated	generate	VBN	VBN	_	0	root	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	tested	test	VBN	VBN	_	36	conj	_	_
39	for	for	IN	IN	_	41	case	_	_
40	promoter	promoter	NN	NN	_	41	compound	_	_
41	activity	activity	NN	NN	_	38	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	various	various	JJ	JJ	_	44	amod	_	_
44	hematopoietic	hematopoietic	JJ	JJ	_	41	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	nonhematopoietic	nonhematopoietic	JJ	JJ	_	44	conj	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	types	type	NNS	NNS	_	44	dep	_	_
49	.	.	.	.	_	36	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	-1053/+34	-1053/+34	CD	CD	_	3	nummod	_	_
3	construct	construct	NN	NN	_	4	nsubj	_	_
4	allowed	allow	VBD	VBD	_	0	root	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	only	only	RB	RB	_	9	advmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
12	origin	origin	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	tissue	tissue	NN	NN	_	16	compound	_	_
16	specificity	specificity	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	conserved	conserve	VBN	VBN	_	4	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	all	all	DT	DT	_	22	det	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	constructs	construct	NNS	NNS	_	18	nmod	_	_
23	tested	test	VBN	VBN	_	22	acl	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	6	nsubj	_	_
3	downstream	downstream	JJ	JJ	_	2	advmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	-90	-90	CD	CD	_	3	nmod	_	_
6	appeared	appear	VBD	VBD	_	0	root	_	_
7	critical	critical	JJ	JJ	_	6	xcomp	_	_
8	for	for	IN	IN	_	11	case	_	_
9	basal	basal	JJ	JJ	_	11	amod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	two	two	CD	CD	_	7	nummod	_	_
4	potential	potential	JJ	JJ	_	7	amod	_	_
5	Ets	ets	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	2	dobj	_	_
8	conserved	conserve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	murine	murine	JJ	JJ	_	14	amod	_	_
12	gammac	gammac	NN	NN	_	14	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	one	one	CD	CD	_	20	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	16	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	2	dep	_	_
21	essential	essential	JJ	JJ	_	20	xcomp	_	_
22	for	for	IN	IN	_	25	case	_	_
23	functional	functional	JJ	JJ	_	25	amod	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	nmod	_	_
26	as	as	IN	IN	_	27	mark	_	_
27	determined	determine	VBN	VBN	_	20	advcl	_	_
28	by	by	IN	IN	_	30	case	_	_
29	mutational	mutational	JJ	JJ	_	30	amod	_	_
30	analysis	analysis	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	functional	functional	JJ	JJ	_	5	amod	_	_
3	Ets	ets	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	bind	bind	VB	VB	_	7	xcomp	_	_
10	Ets	ets	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	principally	principally	RB	RB	_	16	advmod	_	_
15	GA-binding	ga-binding	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	12	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Elf-1	elf-1	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	could	could	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	transactivated	transactivate	VBN	VBN	_	7	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	GABPalpha	gabpalpha	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	-beta	-beta	NN	NN	_	24	conj	_	_
27	synergistically	synergistically	RB	RB	_	22	advmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	,	,	,	,	_	19	punct	_	_
6	as	as	IN	IN	_	8	mark	_	_
7	already	already	RB	RB	_	8	advmod	_	_
8	reported	report	VBN	VBN	_	19	dep	_	_
9	for	for	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL2Rbeta	il2rbeta	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	19	punct	_	_
14	GA-binding	ga-binding	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	19	nsubj	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	an	a	DT	DT	_	19	det	_	_
18	essential	essential	JJ	JJ	_	19	amod	_	_
19	component	component	NN	NN	_	3	advcl	_	_
20	of	of	IN	IN	_	24	case	_	_
21	gammac	gammac	NN	NN	_	24	compound	_	_
22	basal	basal	JJ	JJ	_	24	amod	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	GABP	gabp	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	restricted	restricted	JJ	JJ	_	19	advcl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	10	amod	_	_
10	lineage	lineage	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	19	punct	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	interaction	interaction	NN	NN	_	19	nsubj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	other	other	JJ	JJ	_	17	amod	_	_
16	specific	specific	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	contribute	contribute	VB	VB	_	0	root	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	tissue-specific	tissue-specific	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	gammac	gammac	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	Octamer	octamer	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	their	they	PRP$	PRP$	_	6	nmod:poss	_	_
6	coactivator	coactivator	NN	NN	_	3	conj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	activate	activate	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	15	det	_	_
10	murine	murine	JJ	JJ	_	15	amod	_	_
11	PU.1	pu.1	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	spi-1	spi-1	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	promoter	promoter	NN	NN	_	8	dobj	_	_
16	.	.	.	.	_	8	punct	_	_

1	PU.1	pu.1	NN	NN	_	17	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	spi-1	spi-1	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	member	member	NN	NN	_	1	appos	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	Ets	ets	NN	NN	_	13	compound	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	predominantly	predominantly	RB	RB	_	17	advmod	_	_
17	expressed	express	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	myeloid	myeloid	JJ	JJ	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	B	b	NN	NN	_	19	conj	_	_
22	cells	cell	NNS	NNS	_	19	dep	_	_
23	,	,	,	,	_	17	punct	_	_
24	activates	activate	VBZ	VBZ	_	17	conj	_	_
25	many	many	JJ	JJ	_	27	amod	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cell	cell	NN	NN	_	24	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	myeloid	myeloid	JJ	JJ	_	27	conj	_	_
30	genes	gene	NNS	NNS	_	27	dep	_	_
31	,	,	,	,	_	17	punct	_	_
32	and	and	CC	CC	_	17	cc	_	_
33	is	be	VBZ	VBZ	_	34	cop	_	_
34	critical	critical	JJ	JJ	_	17	conj	_	_
35	for	for	IN	IN	_	36	case	_	_
36	development	development	NN	NN	_	34	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	both	both	DT	DT	_	36	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	these	these	DT	DT	_	41	det	_	_
41	lineages	lineage	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	17	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	45	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	Chen	Chen	NNP	NNP	_	7	compound	_	_
6	,	,	,	,	_	7	punct	_	_
7	H.M.	H.M.	NNP	NNP	_	3	dep	_	_
8	,	,	,	,	_	7	punct	_	_
9	Ray-Gallet	Ray-Gallet	NNP	NNP	_	11	compound	_	_
10	,	,	,	,	_	11	punct	_	_
11	D.	D.	NNP	NNP	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	Zhang	Zhang	NNP	NNP	_	15	compound	_	_
14	,	,	,	,	_	15	punct	_	_
15	P.	P.	NNP	NNP	_	7	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	Hetherington	Hetherington	NNP	NNP	_	19	compound	_	_
18	,	,	,	,	_	19	punct	_	_
19	C.J.	C.J.	NNP	NNP	_	7	conj	_	_
20	,	,	,	,	_	7	punct	_	_
21	Gonzalez	Gonzalez	NNP	NNP	_	23	compound	_	_
22	,	,	,	,	_	23	punct	_	_
23	D.A.	D.A.	NNP	NNP	_	7	conj	_	_
24	,	,	,	,	_	7	punct	_	_
25	Zhang	Zhang	NNP	NNP	_	27	compound	_	_
26	,	,	,	,	_	27	punct	_	_
27	D.-E.	D.-E.	NNP	NNP	_	7	conj	_	_
28	,	,	,	,	_	7	punct	_	_
29	Moreau-Gachelin	Moreau-Gachelin	NNP	NNP	_	31	compound	_	_
30	,	,	,	,	_	31	punct	_	_
31	F.	F.	NNP	NNP	_	7	conj	_	_
32	,	,	,	,	_	7	punct	_	_
33	and	and	CC	CC	_	7	cc	_	_
34	Tenen	Tenen	NNP	NNP	_	36	compound	_	_
35	,	,	,	,	_	36	punct	_	_
36	D.G.	D.G.	NNP	NNP	_	7	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	1995	1995	CD	CD	_	7	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	Oncogene	oncogene	NN	NN	_	7	dep	_	_
41	11	11	CD	CD	_	40	nummod	_	_
42	,	,	,	,	_	7	punct	_	_
43	1549-1560	1549-1560	CD	CD	_	7	amod	_	_
44	)	)	-RRB-	-RRB-	_	7	punct	_	_
45	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
46	that	that	IN	IN	_	50	mark	_	_
47	the	the	DT	DT	_	49	det	_	_
48	PU.1	pu.1	NN	NN	_	49	compound	_	_
49	promoter	promoter	NN	NN	_	50	nsubj	_	_
50	directs	direct	VBZ	VBZ	_	45	ccomp	_	_
51	cell	cell	NN	NN	_	54	compound	_	_
52	type-specific	type-specific	JJ	JJ	_	54	amod	_	_
53	reporter	reporter	NN	NN	_	54	compound	_	_
54	gene	gene	NN	NN	_	55	compound	_	_
55	expression	expression	NN	NN	_	50	dobj	_	_
56	in	in	IN	IN	_	59	case	_	_
57	myeloid	myeloid	JJ	JJ	_	59	amod	_	_
58	cell	cell	NN	NN	_	59	compound	_	_
59	lines	line	NNS	NNS	_	55	nmod	_	_
60	,	,	,	,	_	50	punct	_	_
61	and	and	CC	CC	_	50	cc	_	_
62	that	that	IN	IN	_	64	mark	_	_
63	PU.1	pu.1	NN	NN	_	64	nsubj	_	_
64	activates	activate	VBZ	VBZ	_	50	conj	_	_
65	its	its	PRP$	PRP$	_	67	nmod:poss	_	_
66	own	own	JJ	JJ	_	67	amod	_	_
67	promoter	promoter	NN	NN	_	64	dobj	_	_
68	in	in	IN	IN	_	71	case	_	_
69	an	a	DT	DT	_	71	det	_	_
70	autoregulatory	autoregulatory	JJ	JJ	_	71	amod	_	_
71	loop	loop	NN	NN	_	67	nmod	_	_
72	.	.	.	.	_	45	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	murine	murine	JJ	JJ	_	8	amod	_	_
7	PU.1	pu.1	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	14	nsubj	_	_
9	is	be	VBZ	VBZ	_	14	cop	_	_
10	also	also	RB	RB	_	14	advmod	_	_
11	specifically	specifically	RB	RB	_	12	advmod	_	_
12	and	and	CC	CC	_	14	advmod	_	_
13	highly	highly	RB	RB	_	12	advmod	_	_
14	functional	functional	JJ	JJ	_	3	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	nmod	_	_
19	as	as	RB	RB	_	18	advmod	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	.	.	.	.	_	3	punct	_	_

1	Oct-1	oct-1	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Oct-2	oct-2	NN	NN	_	1	conj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	bind	bind	VB	VB	_	0	root	_	_
6	specifically	specifically	RB	RB	_	9	advmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	site	site	NN	NN	_	5	nmod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	base	base	NN	NN	_	12	compound	_	_
12	pair	pair	NN	NN	_	9	nmod	_	_
13	-55	-55	CD	CD	_	12	nummod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	5	advmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	this	this	DT	DT	_	19	det	_	_
19	site	site	NN	NN	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	specifically	specifically	RB	RB	_	22	advmod	_	_
22	protected	protect	VBN	VBN	_	5	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vivo	vivo	FW	FW	_	22	advmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	sites	site	NNS	NNS	_	8	nsubj	_	_
8	contribute	contribute	VBP	VBP	_	3	ccomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	;	;	:	:	_	3	punct	_	_
16	an	a	DT	DT	_	19	det	_	_
17	Sp1	sp1	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	3	dep	_	_
20	adjacent	adjacent	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	octamer	octamer	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	the	the	DT	DT	_	30	det	_	_
28	PU.1	pu.1	NN	NN	_	30	compound	_	_
29	autoregulatory	autoregulatory	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	19	conj	_	_
31	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cell	cell	NN	NN	_	13	nsubjpass	_	_
9	coactivator	coactivator	NN	NN	_	8	dep	_	_
10	OBF-1/Bob1/OCA-B	obf-1/bob1/oca-b	NN	NN	_	8	dep	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	only	only	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	4	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	in	in	IN	IN	_	21	case	_	_
20	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	16	conj	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	that	that	IN	IN	_	27	mark	_	_
25	OBF-1/Bob1/OCA-B	obf-1/bob1/oca-b	NN	NN	_	27	nsubj	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	transactivate	transactivate	VB	VB	_	13	conj	_	_
28	the	the	DT	DT	_	30	det	_	_
29	PU.1	pu.1	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	HeLa	hela	NN	NN	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	myeloid	myeloid	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	32	conj	_	_
36	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	B	b	NN	NN	_	5	compound	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	restricted	restricted	JJ	JJ	_	5	amod	_	_
5	coactivator	coactivator	NN	NN	_	8	nsubj	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	responsible	responsible	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	PU.1	pu.1	NN	NN	_	14	nmod	_	_
17	mediated	mediate	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	octamer	octamer	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Multiple	multiple	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	interleukin	interleukin	NN	NN	_	12	compound	_	_
11	9	9	CD	CD	_	12	nummod	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	dep	_	_
2	genetic	genetic	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	34	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	3	conj	_	_
7	responsible	responsible	JJ	JJ	_	3	amod	_	_
8	for	for	IN	IN	_	16	case	_	_
9	human	human	JJ	JJ	_	15	amod	_	_
10	interleukin	interleukin	NN	NN	_	15	compound	_	_
11	9	9	CD	CD	_	15	nummod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	IL-9	il-9	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	7	nmod	_	_
17	in	in	IN	IN	_	29	case	_	_
18	a	a	DT	DT	_	29	det	_	_
19	human	human	JJ	JJ	_	29	amod	_	_
20	T	t	NN	NN	_	29	compound	_	_
21	cell	cell	NN	NN	_	29	compound	_	_
22	leukemia	leukemia	NN	NN	_	29	compound	_	_
23	virus	virus	NN	NN	_	29	compound	_	_
24	type	type	NN	NN	_	29	compound	_	_
25	I-transformed	i-transformed	JJ	JJ	_	29	amod	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	16	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	C5MJ2	c5mj2	NN	NN	_	29	appos	_	_
32	,	,	,	,	_	3	punct	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	investigated	investigate	VBN	VBN	_	0	root	_	_
35	.	.	.	.	_	34	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	IL-9	il-9	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	controlled	control	VBN	VBN	_	2	ccomp	_	_
9	,	,	,	,	_	8	punct	_	_
10	at	at	IN	IN	_	13	advmod	_	_
11	least	least	JJS	JJS	_	10	mwe	_	_
12	in	in	IN	IN	_	13	case	_	_
13	part	part	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	by	by	IN	IN	_	17	case	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	luciferase	luciferase	NN	NN	_	7	compound	_	_
6	reporter	reporter	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	linked	link	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	12	case	_	_
10	serially	serially	RB	RB	_	11	advmod	_	_
11	deleted	delete	VBN	VBN	_	12	amod	_	_
12	sequences	sequence	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	5'-flanking	5'-flanking	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-9	il-9	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	has	have	VBZ	VBZ	_	22	aux	_	_
22	revealed	reveal	VBN	VBN	_	0	root	_	_
23	several	several	JJ	JJ	_	24	amod	_	_
24	positive	positive	JJ	JJ	_	22	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	negative	negative	JJ	JJ	_	28	amod	_	_
27	regulatory	regulatory	JJ	JJ	_	28	amod	_	_
28	elements	element	NNS	NNS	_	24	conj	_	_
29	involved	involve	VBN	VBN	_	24	acl	_	_
30	in	in	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	basal	basal	JJ	JJ	_	35	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	inducible	inducible	JJ	JJ	_	32	conj	_	_
35	expression	expression	NN	NN	_	29	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	IL-9	il-9	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	35	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	C5MJ2	c5mj2	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	35	nmod	_	_
43	.	.	.	.	_	22	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	AP-1	ap-1	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	9	nsubjpass	_	_
4	at	at	IN	IN	_	7	case	_	_
5	-146	-146	CD	CD	_	7	nummod	_	_
6	to	to	TO	TO	_	7	dep	_	_
7	-140	-140	CD	CD	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	9	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-9	il-9	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	proximal	proximal	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	9	nsubjpass	_	_
4	between	between	IN	IN	_	5	case	_	_
5	-46	-46	CD	CD	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	-80	-80	CD	CD	_	5	conj	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	identified	identify	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	minimum	minimum	JJ	JJ	_	13	amod	_	_
13	sequence	sequence	NN	NN	_	9	nmod	_	_
14	for	for	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	basal	basal	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	inducible	inducible	JJ	JJ	_	16	conj	_	_
19	expression	expression	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-9	il-9	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	C5MJ2	c5mj2	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	20	nmod	_	_
4	,	,	,	,	_	20	punct	_	_
5	an	a	DT	DT	_	7	det	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	20	nsubjpass	_	_
8	at	at	IN	IN	_	11	case	_	_
9	-59	-59	CD	CD	_	11	nummod	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	-50	-50	CD	CD	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
14	adjacent	adjacent	JJ	JJ	_	18	amod	_	_
15	20-base	20-base	JJ	JJ	_	18	amod	_	_
16	pair	pair	NN	NN	_	18	compound	_	_
17	upstream	upstream	JJ	JJ	_	18	amod	_	_
18	sequence	sequence	NN	NN	_	7	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	play	play	VB	VB	_	20	xcomp	_	_
23	a	a	DT	DT	_	25	det	_	_
24	critical	critical	JJ	JJ	_	25	amod	_	_
25	role	role	NN	NN	_	22	dobj	_	_
26	for	for	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	IL-9	il-9	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	20	punct	_	_

1	DNA-protein	dna-protein	JJ	JJ	_	3	amod	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	20	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	c-Jun	c-jun	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	potentially	potentially	RB	RB	_	13	advmod	_	_
12	novel	novel	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	6	conj	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	around	around	IN	IN	_	17	case	_	_
16	35	35	CD	CD	_	17	nummod	_	_
17	kDa	kda	NN	NN	_	13	nmod	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	bind	bind	VB	VB	_	4	ccomp	_	_
21	to	to	TO	TO	_	24	case	_	_
22	this	this	DT	DT	_	24	det	_	_
23	important	important	JJ	JJ	_	24	amod	_	_
24	sequence	sequence	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Mutations	mutation	NNS	NNS	_	10	nsubj	_	_
2	at	at	IN	IN	_	4	case	_	_
3	different	different	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	1	nmod	_	_
5	within	within	IN	IN	_	9	case	_	_
6	this	this	DT	DT	_	9	det	_	_
7	proximal	proximal	JJ	JJ	_	9	amod	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	region	region	NN	NN	_	4	nmod	_	_
10	abolished	abolish	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	as	as	RB	RB	_	13	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	the	the	DT	DT	_	19	det	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	13	conj	_	_
20	.	.	.	.	_	10	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cooperation	cooperation	NN	NN	_	15	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	different	different	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	essential	essential	JJ	JJ	_	6	ccomp	_	_
16	for	for	IN	IN	_	19	case	_	_
17	IL-9	il-9	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	3'	3'	JJ	JJ	_	7	compound	_	_
3	--&gt;	--&gt;	TO	TO	_	2	dep	_	_
4	5'	5'	JJ	JJ	_	2	dep	_	_
5	XPB	xpb	NN	NN	_	7	compound	_	_
6	helicase	helicase	NN	NN	_	7	compound	_	_
7	defect	defect	NN	NN	_	17	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	repair/transcription	repair/transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	TFIIH	tfiih	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	xeroderma	xeroderma	NN	NN	_	16	compound	_	_
14	pigmentosum	pigmentosum	NN	NN	_	16	compound	_	_
15	group	group	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	11	nmod	_	_
17	affects	affect	VBZ	VBZ	_	0	root	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	DNA	dna	NN	NN	_	17	dobj	_	_
20	repair	repair	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	transcription	transcription	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	17	punct	_	_

1	XPB	xpb	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	subunit	subunit	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	basal	basal	JJ	JJ	_	10	amod	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	TFIIH	tfiih	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	which	which	WDT	WDT	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	involved	involve	VBN	VBN	_	4	acl:relcl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	nucleotide	nucleotide	NN	NN	_	19	compound	_	_
18	excision	excision	NN	NN	_	19	compound	_	_
19	repair	repair	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	NER	ner	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	potentially	potentially	RB	RB	_	15	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	cycle	cycle	NN	NN	_	28	compound	_	_
28	regulation	regulation	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	frameshift	frameshift	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	12	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	3'-end	3'-end	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	XPB	xpb	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	responsible	responsible	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	concurrence	concurrence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	disorders	disorder	NNS	NNS	_	15	nmod	_	_
19	:	:	:	:	_	18	punct	_	_
20	xeroderma	xeroderma	NN	NN	_	21	compound	_	_
21	pigmentosum	pigmentosum	NN	NN	_	18	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	XP	xp	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	Cockayne	cockayne	NN	NN	_	28	nmod:poss	_	_
27	's	's	POS	POS	_	26	case	_	_
28	syndrome	syndrome	NN	NN	_	21	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CS	cs	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	TFIIH	tfiih	NN	NN	_	3	dobj	_	_
5	from	from	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	derived	derive	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	patient	patient	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	XP11BE	xp11be	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	who	who	WP	WP	_	15	nsubj	_	_
15	carries	carry	VBZ	VBZ	_	10	acl:relcl	_	_
16	this	this	DT	DT	_	18	det	_	_
17	frameshift	frameshift	NN	NN	_	18	compound	_	_
18	mutation	mutation	NN	NN	_	15	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TFIIHmut	tfiihmut	NN	NN	_	6	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	mother	mother	NN	NN	_	30	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	patient	patient	NN	NN	_	25	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TFIIHwt	tfiihwt	NN	NN	_	6	conj	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	determine	determine	VB	VB	_	3	advcl	_	_
34	the	the	DT	DT	_	36	det	_	_
35	biochemical	biochemical	JJ	JJ	_	36	amod	_	_
36	consequences	consequence	NNS	NNS	_	33	dobj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	mutation	mutation	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	2	mark	_	_
2	identical	identical	JJ	JJ	_	11	advcl	_	_
3	in	in	IN	IN	_	4	case	_	_
4	composition	composition	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	stoichiometry	stoichiometry	NN	NN	_	4	conj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	TFIIHwt	tfiihwt	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	TFIIHmut	tfiihmut	NN	NN	_	11	nsubj	_	_
11	shows	show	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	19	det	_	_
13	reduced	reduce	VBN	VBN	_	19	amod	_	_
14	3'	3'	JJ	JJ	_	19	compound	_	_
15	--&gt;	--&gt;	TO	TO	_	14	dep	_	_
16	5'	5'	JJ	JJ	_	14	dep	_	_
17	XPB	xpb	NN	NN	_	19	compound	_	_
18	helicase	helicase	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	11	dobj	_	_
20	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	11	nsubjpass	_	_
3	in	in	IN	IN	_	8	case	_	_
4	helicase	helicase	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	DNA-dependent	dna-dependent	JJ	JJ	_	7	amod	_	_
7	ATPase	atpase	NN	NN	_	4	conj	_	_
8	activities	activity	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	mutated	mutate	VBN	VBN	_	17	amod	_	_
15	recombinant	recombinant	JJ	JJ	_	17	amod	_	_
16	XPB	xpb	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	XPB	xpb	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	4	nsubj	_	_
4	causes	cause	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	dep	_	_
6	severe	severe	JJ	JJ	_	7	dep	_	_
7	NER	ner	NN	NN	_	4	dep	_	_
8	defect	defect	NN	NN	_	7	dep	_	_
9	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	decrease	decrease	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	basal	basal	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	13	advmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	defect	defect	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	provide	provide	VB	VB	_	0	root	_	_
6	an	a	DT	DT	_	7	det	_	_
7	explanation	explanation	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	many	many	JJ	JJ	_	7	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	XP	xp	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CS	cs	NN	NN	_	12	conj	_	_
15	symptoms	symptom	NNS	NNS	_	9	nmod	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	difficult	difficult	JJ	JJ	_	15	acl:relcl	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	rationalize	rationalize	VB	VB	_	18	ccomp	_	_
21	based	base	VBN	VBN	_	26	case	_	_
22	solely	solely	RB	RB	_	26	advmod	_	_
23	on	on	IN	IN	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	NER	ner	NN	NN	_	26	compound	_	_
26	defect	defect	NN	NN	_	20	advcl	_	_
27	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	work	work	NN	NN	_	5	nsubj	_	_
5	presents	present	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	first	first	JJ	JJ	_	9	amod	_	_
8	detailed	detailed	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	naturally	naturally	RB	RB	_	13	advmod	_	_
13	occurring	occur	VBG	VBG	_	14	amod	_	_
14	mutation	mutation	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	basal	basal	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	5	cc	_	_
21	supports	support	VBZ	VBZ	_	5	conj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	concept	concept	NN	NN	_	21	dobj	_	_
24	that	that	IN	IN	_	33	mark	_	_
25	the	the	DT	DT	_	29	det	_	_
26	combined	combined	JJ	JJ	_	29	amod	_	_
27	XP/CS	xp/cs	NN	NN	_	29	compound	_	_
28	clinical	clinical	JJ	JJ	_	29	amod	_	_
29	entity	entity	NN	NN	_	33	nsubj	_	_
30	is	be	VBZ	VBZ	_	33	cop	_	_
31	actually	actually	RB	RB	_	33	advmod	_	_
32	the	the	DT	DT	_	33	det	_	_
33	result	result	NN	NN	_	23	ccomp	_	_
34	of	of	IN	IN	_	38	case	_	_
35	a	a	DT	DT	_	38	det	_	_
36	combined	combined	JJ	JJ	_	38	amod	_	_
37	transcription/repair	transcription/repair	NN	NN	_	38	compound	_	_
38	deficiency	deficiency	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	Signals	signal	NNS	NNS	_	12	nsubj	_	_
2	leading	lead	VBG	VBG	_	1	acl	_	_
3	to	to	TO	TO	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	5	nmod	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	stronger	stronger	JJR	JJR	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neonatal	neonatal	JJ	JJ	_	12	nmod	_	_
15	than	than	IN	IN	_	18	case	_	_
16	adult	adult	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	background	background	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	defects	defect	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	reactivity	reactivity	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	neonates	neonate	NNS	NNS	_	10	nmod	_	_
14	has	have	VBZ	VBZ	_	18	aux	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	been	be	VBN	VBN	_	18	auxpass	_	_
17	fully	fully	RB	RB	_	18	advmod	_	_
18	elucidated	elucidate	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	As	as	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	6	det	_	_
3	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	29	advcl	_	_
8	a	a	DT	DT	_	10	det	_	_
9	central	central	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	control	control	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	15	nmod	_	_
19	involved	involve	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	24	case	_	_
21	immune	immune	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	inflammatory	inflammatory	JJ	JJ	_	21	conj	_	_
24	responses	response	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	29	punct	_	_
26	the	the	DT	DT	_	27	det	_	_
27	authors	author	NNS	NNS	_	29	nsubj	_	_
28	have	have	VBP	VBP	_	29	aux	_	_
29	analysed	analyse	VBN	VBN	_	0	root	_	_
30	the	the	DT	DT	_	31	det	_	_
31	activation	activation	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	40	case	_	_
36	human	human	JJ	JJ	_	40	amod	_	_
37	umbilical	umbilical	JJ	JJ	_	40	amod	_	_
38	cord	cord	NN	NN	_	40	compound	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	lymphocytes	lymphocyte	NNS	NNS	_	31	nmod	_	_
41	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	tested	test	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	quantitating	quantitate	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	proteins	protein	NNS	NNS	_	6	dobj	_	_
10	binding	bind	VBG	VBG	_	9	acl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	an	a	DT	DT	_	13	det	_	_
13	oligonucleotide	oligonucleotide	NN	NN	_	10	nmod	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	20	det	_	_
16	consensus	consensus	NN	NN	_	20	compound	_	_
17	kappa	kappa	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	14	dobj	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	25	amod	_	_
23	mobility	mobility	NN	NN	_	25	compound	_	_
24	shift	shift	NN	NN	_	25	compound	_	_
25	assay	assay	NN	NN	_	6	dep	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	phorbol	phorbol	NN	NN	_	9	compound	_	_
7	dibutyrate/calcium	dibutyrate/calcium	NN	NN	_	9	compound	_	_
8	ionophore	ionophore	NN	NN	_	9	compound	_	_
9	A23187	a23187	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PDBu/iono	pdbu/iono	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	combination	combination	NN	NN	_	14	nsubj	_	_
14	induced	induce	VBD	VBD	_	4	ccomp	_	_
15	a	a	DT	DT	_	19	det	_	_
16	clearly	clearly	RB	RB	_	17	advmod	_	_
17	higher	higher	JJR	JJR	_	19	amod	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	translocation	translocation	NN	NN	_	14	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	neonatal	neonatal	JJ	JJ	_	19	nmod	_	_
25	than	than	IN	IN	_	28	case	_	_
26	adult	adult	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	19	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	higher	higher	JJR	JJR	_	5	amod	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	aux	_	_
7	restricted	restricted	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	subset	subset	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Analysis	analysis	NN	NN	_	25	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	antibodies	antibody	NNS	NNS	_	5	nmod	_	_
8	directed	direct	VBN	VBN	_	7	acl	_	_
9	against	against	IN	IN	_	23	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	major	major	JJ	JJ	_	12	amod	_	_
12	components	component	NNS	NNS	_	23	compound	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	nmod	_	_
16	the	the	DT	DT	_	23	det	_	_
17	p50	p50	NN	NN	_	23	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	RelA	rela	NN	NN	_	17	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	p65	p65	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	proteins	protein	NNS	NNS	_	8	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	indicated	indicate	VBD	VBD	_	0	root	_	_
26	that	that	IN	IN	_	33	mark	_	_
27	the	the	DT	DT	_	28	det	_	_
28	composition	composition	NN	NN	_	33	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	28	nmod	_	_
32	was	be	VBD	VBD	_	33	cop	_	_
33	similar	similar	JJ	JJ	_	25	ccomp	_	_
34	in	in	IN	IN	_	38	case	_	_
35	neonatal	neonatal	JJ	JJ	_	38	amod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	adult	adult	JJ	JJ	_	35	conj	_	_
38	cells	cell	NNS	NNS	_	33	nmod	_	_
39	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	neonatal	neonatal	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	exposed	expose	VBN	VBN	_	3	ccomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	oxidative	oxidative	JJ	JJ	_	12	amod	_	_
12	stress-inducing	stress-inducing	JJ	JJ	_	13	amod	_	_
13	signals	signal	NNS	NNS	_	9	nmod	_	_
14	during	during	IN	IN	_	15	case	_	_
15	delivery	delivery	NN	NN	_	9	nmod	_	_
16	and/or	and/or	CC	CC	_	9	cc	_	_
17	are	be	VBP	VBP	_	20	cop	_	_
18	inherently	inherently	RB	RB	_	20	advmod	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	sensitive	sensitive	JJ	JJ	_	9	conj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	activating	activating	NN	NN	_	25	compound	_	_
25	signals	signal	NNS	NNS	_	20	nmod	_	_
26	than	than	IN	IN	_	29	case	_	_
27	adult	adult	JJ	JJ	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	20	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Grb2-binding	grb2-binding	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	platelets	platelet	NNS	NNS	_	4	nmod	_	_
8	activated	activate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	13	case	_	_
10	Fc	fc	NN	NN	_	13	compound	_	_
11	gamma	gamma	NN	NN	_	13	compound	_	_
12	RIIA	riia	NN	NN	_	13	compound	_	_
13	cross-linking	cross-linking	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Glutathione-S-transferase	glutathione-s-transferase	NN	NN	_	5	dep	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	GST	gst	NN	NN	_	5	dep	_	_
4	)	)	-RRB-	-RRB-	_	5	punct	_	_
5	-Grb2	-grb2	NN	NN	_	7	amod	_	_
6	fusion	fusion	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	10	nsubjpass	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	used	use	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	identify	identify	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	potential	potential	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Grb2-binding	grb2-binding	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	platelet	platelet	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	15	nmod	_	_
22	by	by	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	platelet	platelet	NN	NN	_	27	compound	_	_
25	low-affinity	low-affinity	NN	NN	_	27	compound	_	_
26	IgG	igg	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	21	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	Fc	fc	NN	NN	_	31	compound	_	_
30	gamma	gamma	NN	NN	_	31	compound	_	_
31	RIIA	riia	NN	NN	_	27	appos	_	_
32	.	.	.	.	_	10	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphoproteins	phosphoprotein	NNS	NNS	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	38	38	CD	CD	_	8	nummod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	63	63	CD	CD	_	5	conj	_	_
8	kD	kd	NN	NN	_	3	nmod	_	_
9	bind	bind	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	SH2	sh2	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Grb2	grb2	NN	NN	_	13	nmod	_	_
16	following	follow	VBG	VBG	_	20	case	_	_
17	Fc	fc	NN	NN	_	20	compound	_	_
18	gamma	gamma	NN	NN	_	20	compound	_	_
19	RIIA	riia	NN	NN	_	20	compound	_	_
20	stimulation	stimulation	NN	NN	_	9	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	platelets	platelet	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Both	both	DT	DT	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	located	located	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	particulate	particulate	JJ	JJ	_	7	amod	_	_
7	fraction	fraction	NN	NN	_	3	nmod	_	_
8	following	follow	VBG	VBG	_	10	case	_	_
9	platelet	platelet	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	3	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	able	able	JJ	JJ	_	3	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	bind	bind	VB	VB	_	14	xcomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	GST-construct	gst-construct	NN	NN	_	16	nmod	_	_
20	containing	contain	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	25	det	_	_
22	SH2	sh2	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	SH3	sh3	NN	NN	_	22	conj	_	_
25	domains	domain	NNS	NNS	_	20	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	phospholipase	phospholipase	NN	NN	_	29	compound	_	_
28	C	c	NN	NN	_	29	compound	_	_
29	gamma	gamma	NN	NN	_	25	nmod	_	_
30	1	1	CD	CD	_	29	nummod	_	_
31	.	.	.	.	_	3	punct	_	_

1	p38	p38	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	forms	form	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	complex	complex	NN	NN	_	3	dobj	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	csk	csk	NN	NN	_	3	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	stimulated	stimulate	VBN	VBN	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	a	a	DT	DT	_	17	det	_	_
17	substrate	substrate	NN	NN	_	3	conj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	kinase	kinase	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	SH3	sh3	NN	NN	_	3	compound	_	_
3	domains	domain	NNS	NNS	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Grb2	grb2	NN	NN	_	3	nmod	_	_
6	form	form	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	stable	stable	JJ	JJ	_	9	amod	_	_
9	complex	complex	NN	NN	_	6	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	SOS1	sos1	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	proteins	protein	NNS	NNS	_	11	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	75	75	CD	CD	_	17	nummod	_	_
17	kD	kd	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	120	120	CD	CD	_	20	nummod	_	_
20	kD	kd	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	undergo	undergo	VBP	VBP	_	14	acl:relcl	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	phosphorylation	phosphorylation	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	31	case	_	_
27	Fc	fc	NN	NN	_	29	compound	_	_
28	gamma	gamma	NN	NN	_	29	compound	_	_
29	RIIA	riia	NN	NN	_	30	nmod:npmod	_	_
30	stimulated	stimulated	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	23	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	75-kD	75-kd	JJ	JJ	_	3	amod	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	recognized	recognize	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	antibodies	antibody	NNS	NNS	_	5	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	SLP-76	slp-76	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	15	nsubjpass	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	recently	recently	RB	RB	_	15	advmod	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	isolated	isolate	VBN	VBN	_	9	acl:relcl	_	_
16	from	from	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	sequenced	sequence	VBN	VBN	_	5	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p38	p38	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p63	p63	NN	NN	_	4	conj	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	observed	observe	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	platelets	platelet	NNS	NNS	_	9	nmod	_	_
12	stimulated	stimulate	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	tyrosine	tyrosine	NN	NN	_	16	nmod:npmod	_	_
16	kinase-linked	kinase-linked	JJ	JJ	_	19	amod	_	_
17	receptor	receptor	NN	NN	_	19	compound	_	_
18	agonist	agonist	NN	NN	_	19	compound	_	_
19	collagen	collagen	NN	NN	_	12	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	by	by	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	G	g	NN	NN	_	24	nmod:npmod	_	_
24	protein-coupled	protein-coupled	JJ	JJ	_	27	amod	_	_
25	receptor	receptor	NN	NN	_	27	compound	_	_
26	agonist	agonist	NN	NN	_	27	compound	_	_
27	thrombin	thrombin	NN	NN	_	19	conj	_	_
28	,	,	,	,	_	9	punct	_	_
29	although	although	IN	IN	_	35	mark	_	_
30	phosphorylation	phosphorylation	NN	NN	_	35	nsubjpass	_	_
31	of	of	IN	IN	_	32	case	_	_
32	SLP-76	slp-76	NN	NN	_	30	nmod	_	_
33	is	be	VBZ	VBZ	_	35	auxpass	_	_
34	only	only	RB	RB	_	35	advmod	_	_
35	observed	observe	VBN	VBN	_	9	advcl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	collagen-stimulated	collagen-stimulated	JJ	JJ	_	38	amod	_	_
38	platelets	platelet	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	9	punct	_	_

1	p38	p38	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p63	p63	NN	NN	_	1	conj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	provide	provide	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	docking	docking	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	5	dobj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	Grb2	grb2	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	thereby	thereby	RB	RB	_	13	advmod	_	_
13	linking	link	VBG	VBG	_	5	advcl	_	_
14	Grb2	grb2	NN	NN	_	16	compound	_	_
15	SH3-binding	sh3-binding	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	13	dobj	_	_
17	SOS1	sos1	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	SLP-76	slp-76	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	p120	p120	NN	NN	_	17	conj	_	_
23	to	to	TO	TO	_	26	case	_	_
24	downstream	downstream	JJ	JJ	_	26	amod	_	_
25	signalling	signalling	NN	NN	_	26	compound	_	_
26	events	event	NNS	NNS	_	13	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	interferon	interferon	NN	NN	_	8	compound	_	_
5	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
6	factor-1	factor-1	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	All-trans-retinoic	all-trans-retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	ATRA	atra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	the	the	DT	DT	_	8	det	_	_
8	drug	drug	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	choice	choice	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	treatment	treatment	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	promyelocytic	promyelocytic	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	APL	apl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	8	punct	_	_

1	ATRA	atra	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	in	in	FW	FW	_	9	amod	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	in	in	FW	FW	_	4	conj	_	_
8	vivo	vivo	FW	FW	_	7	dep	_	_
9	differentiation	differentiation	NN	NN	_	2	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	APL	apl	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	into	into	IN	IN	_	15	case	_	_
14	mature	mature	JJ	JJ	_	15	amod	_	_
15	granulocytes	granulocyte	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	17	nsubjpass	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	10	case	_	_
8	ATRA-dependent	atra-dependent	JJ	JJ	_	10	amod	_	_
9	growth	growth	NN	NN	_	10	compound	_	_
10	inhibition	inhibition	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	10	conj	_	_
14	are	be	VBP	VBP	_	17	auxpass	_	_
15	not	not	RB	RB	_	17	neg	_	_
16	presently	presently	RB	RB	_	17	advmod	_	_
17	understood	understand	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	NB4	nb4	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	line	line	NN	NN	_	23	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	derived	derive	VBN	VBN	_	4	acl:relcl	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	bone	bone	NN	NN	_	12	compound	_	_
12	marrow	marrow	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	patient	patient	NN	NN	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	APL	apl	NN	NN	_	15	nmod	_	_
18	during	during	IN	IN	_	19	case	_	_
19	relapse	relapse	NN	NN	_	8	nmod	_	_
20	,	,	,	,	_	4	punct	_	_
21	can	can	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	used	use	VBN	VBN	_	0	root	_	_
24	as	as	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	model	model	JJ	JJ	_	27	amod	_	_
27	system	system	NN	NN	_	23	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	study	study	VB	VB	_	27	acl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	growth	growth	NN	NN	_	29	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	differentiation	differentiation	NN	NN	_	31	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	APL	apl	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	23	punct	_	_

1	Because	because	IN	IN	_	18	mark	_	_
2	interferon	interferon	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IFN	ifn	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	factors	factor	NNS	NNS	_	18	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IRF-1	irf-1	NN	NN	_	7	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IRF-2	irf-2	NN	NN	_	9	conj	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	other	other	JJ	JJ	_	17	amod	_	_
15	IFN-inducible	ifn-inducible	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	products	product	NNS	NNS	_	7	conj	_	_
18	regulate	regulate	VBP	VBP	_	23	advcl	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	growth	growth	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	23	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	analyzed	analyze	VBD	VBD	_	0	root	_	_
24	the	the	DT	DT	_	25	det	_	_
25	effects	effect	NNS	NNS	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	ATRA	atra	NN	NN	_	25	nmod	_	_
28	on	on	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	expression	expression	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	these	these	DT	DT	_	33	det	_	_
33	genes	gene	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	ATRA	atra	NN	NN	_	6	nsubj	_	_
5	directly	directly	RB	RB	_	6	advmod	_	_
6	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
7	IRF-1	irf-1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	followed	follow	VBN	VBN	_	6	advcl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	24	case	_	_
15	IRF-2	irf-2	NN	NN	_	24	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	2'-5'	2'-5'	JJ	JJ	_	19	amod	_	_
18	oligoadenylate	oligoadenylate	NN	NN	_	19	compound	_	_
19	synthetase	synthetase	NN	NN	_	15	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	OAS	oas	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	13	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	slower	slower	JJR	JJR	_	27	amod	_	_
27	kinetics	kinetics	NNS	NNS	_	13	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	addition	addition	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	NB4	nb4	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	ATRA	atra	NN	NN	_	9	nsubj	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	activated	activate	VBD	VBD	_	0	root	_	_
10	IRF-1	irf-1	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	20	case	_	_
14	HL-60	hl-60	NN	NN	_	20	compound	_	_
15	,	,	,	,	_	14	punct	_	_
16	U937	u937	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	THP-1	thp-1	NN	NN	_	14	conj	_	_
20	cells	cell	NNS	NNS	_	12	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	dobj	_	_
23	all	all	DT	DT	_	24	nsubj	_	_
24	respond	respond	VBP	VBP	_	20	acl:relcl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	ATRA	atra	NN	NN	_	24	nmod	_	_
27	by	by	IN	IN	_	29	case	_	_
28	growth	growth	NN	NN	_	29	compound	_	_
29	inhibition	inhibition	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	more	more	JJR	JJR	_	5	amod	_	_
3	than	than	IN	IN	_	4	case	_	_
4	additive	additive	JJ	JJ	_	2	advcl	_	_
5	increase	increase	NN	NN	_	11	nsubjpass	_	_
6	in	in	IN	IN	_	9	case	_	_
7	IRF-1	irf-1	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	ATRA	atra	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	NB4	nb4	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	ATRA	atra	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	activate	activate	VB	VB	_	0	root	_	_
5	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
6	factor	factor	NN	NN	_	8	compound	_	_
7	kappa	kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	4	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transducer	transducer	NN	NN	_	20	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activator	activator	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	STAT	stat	NN	NN	_	11	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	pathways	pathway	NNS	NNS	_	8	conj	_	_
21	,	,	,	,	_	4	punct	_	_
22	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
23	that	that	IN	IN	_	28	mark	_	_
24	an	a	DT	DT	_	26	det	_	_
25	alternate	alternate	JJ	JJ	_	26	amod	_	_
26	mechanism	mechanism	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	involved	involve	VBN	VBN	_	22	ccomp	_	_
29	in	in	IN	IN	_	32	case	_	_
30	IRF-1	irf-1	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ATRA-induced	atra-induced	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IRF-1	irf-1	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	an	a	DT	DT	_	8	det	_	_
8	activator	activator	NN	NN	_	5	appos	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	repressor	repressor	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	transformation	transformation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	one	one	CD	CD	_	0	root	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	molecular	molecular	JJ	JJ	_	22	amod	_	_
22	mechanisms	mechanism	NNS	NNS	_	18	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	ATRA-induced	atra-induced	JJ	JJ	_	26	amod	_	_
25	growth	growth	NN	NN	_	26	compound	_	_
26	inhibition	inhibition	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	basis	basis	NN	NN	_	18	conj	_	_
31	for	for	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	synergistic	synergistic	JJ	JJ	_	34	amod	_	_
34	actions	action	NNS	NNS	_	30	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	ATRA	atra	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	IFNs	ifns	NN	NN	_	36	conj	_	_
39	in	in	IN	IN	_	42	case	_	_
40	myeloid	myeloid	JJ	JJ	_	42	amod	_	_
41	leukemia	leukemia	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	34	nmod	_	_
43	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	c-Jun	c-jun	NN	NN	_	3	compound	_	_
3	delta-domain	delta-domain	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	neuroendocrine	neuroendocrine	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	DNA	dna	NN	NN	_	11	compound	_	_
11	sequence-	sequence-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	pituitary-specific	pituitary-specific	JJ	JJ	_	11	conj	_	_
14	manner	manner	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	transcription	transcription	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	transformation	transformation	NN	NN	_	2	conj	_	_
5	activity	activity	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	c-Jun	c-jun	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	governed	govern	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	27-amino	27-amino	JJ	JJ	_	15	amod	_	_
13	acid	acid	NN	NN	_	15	compound	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	motif	motif	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	labeled	label	VBN	VBN	_	15	acl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	delta-domain	delta-domain	NN	NN	_	17	xcomp	_	_
20	,	,	,	,	_	15	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	deleted	delete	VBN	VBN	_	15	acl:relcl	_	_
24	in	in	IN	IN	_	25	case	_	_
25	v-Jun	v-jun	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	c-Jun	c-jun	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	potent	potent	JJ	JJ	_	10	amod	_	_
10	inhibitor	inhibitor	NN	NN	_	4	ccomp	_	_
11	of	of	IN	IN	_	19	case	_	_
12	the	the	DT	DT	_	19	det	_	_
13	rat	rat	NN	NN	_	14	compound	_	_
14	prolactin	prolactin	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	rPRL	rprl	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	10	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	either	either	DT	DT	_	24	cc:preconj	_	_
23	oncogenic	oncogenic	JJ	JJ	_	24	amod	_	_
24	Ras	ras	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	phorbol	phorbol	NN	NN	_	27	compound	_	_
27	esters	ester	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	characterized	characterize	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	10	det	_	_
7	structural	structural	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cell-specific	cell-specific	JJ	JJ	_	7	conj	_	_
10	requirements	requirement	NNS	NNS	_	5	dobj	_	_
11	for	for	IN	IN	_	15	case	_	_
12	this	this	DT	DT	_	15	det	_	_
13	c-Jun	c-jun	NN	NN	_	15	compound	_	_
14	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	show	show	VBP	VBP	_	5	conj	_	_
20	that	that	IN	IN	_	35	mark	_	_
21	this	this	DT	DT	_	24	det	_	_
22	c-Jun	c-jun	NN	NN	_	24	compound	_	_
23	inhibitory	inhibitory	JJ	JJ	_	24	amod	_	_
24	response	response	NN	NN	_	35	nsubj	_	_
25	mapped	map	VBD	VBD	_	24	acl	_	_
26	to	to	TO	TO	_	32	case	_	_
27	the	the	DT	DT	_	32	det	_	_
28	rPRL	rprl	NN	NN	_	32	compound	_	_
29	footprint	footprint	NN	NN	_	32	compound	_	_
30	II	ii	CD	CD	_	32	nummod	_	_
31	repressor	repressor	NN	NN	_	32	compound	_	_
32	site	site	NN	NN	_	25	nmod	_	_
33	,	,	,	,	_	35	punct	_	_
34	was	be	VBD	VBD	_	35	cop	_	_
35	pituitary-specific	pituitary-specific	JJ	JJ	_	19	ccomp	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	required	require	VBD	VBD	_	35	conj	_	_
38	the	the	DT	DT	_	40	det	_	_
39	c-Jun	c-jun	NN	NN	_	40	compound	_	_
40	delta-domain	delta-domain	NN	NN	_	37	dobj	_	_
41	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	alteration	alteration	NN	NN	_	21	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	any	any	DT	DT	_	6	det	_	_
6	one	one	CD	CD	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	features	feature	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	e.g.	e.g.	FW	FW	_	13	advmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	cis-element	cis-element	NN	NN	_	9	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	trans-factor	trans-factor	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	or	or	CC	CC	_	13	cc	_	_
18	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
19	background	background	NN	NN	_	13	conj	_	_
20	)	)	-RRB-	-RRB-	_	13	punct	_	_
21	switched	switch	VBD	VBD	_	0	root	_	_
22	c-Jun	c-jun	NN	NN	_	21	dobj	_	_
23	to	to	TO	TO	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activator	activator	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	rPRL	rprl	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	HeLa	hela	NN	NN	_	4	compound	_	_
3	nonpituitary	nonpituitary	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	c-Jun	c-jun	NN	NN	_	8	nsubj	_	_
7	alone	alone	RB	RB	_	6	advmod	_	_
8	activated	activate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	rPRL	rprl	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	8	dobj	_	_
12	via	via	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	most	most	RBS	RBS	_	15	advmod	_	_
15	proximal	proximal	JJ	JJ	_	18	amod	_	_
16	GHF-1/Pit-1	ghf-1/pit-1	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	8	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	footprint	footprint	NN	NN	_	21	compound	_	_
21	I	i	NN	NN	_	18	appos	_	_
22	,	,	,	,	_	8	punct	_	_
23	and	and	CC	CC	_	8	cc	_	_
24	synergized	synergize	VBD	VBD	_	8	conj	_	_
25	with	with	IN	IN	_	26	case	_	_
26	GHF-1	ghf-1	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
4	GHF-1	ghf-1	NN	NN	_	5	nsubj	_	_
5	interacted	interact	VBD	VBD	_	0	root	_	_
6	directly	directly	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	12	case	_	_
8	c-Jun	c-jun	NN	NN	_	12	compound	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	c-Fos	c-fos	NN	NN	_	8	conj	_	_
12	proteins	protein	NNS	NNS	_	5	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	fundamental	fundamental	JJ	JJ	_	6	amod	_	_
6	insights	insight	NNS	NNS	_	3	dobj	_	_
7	into	into	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	NN	NN	_	10	compound	_	_
10	mechanisms	mechanism	NNS	NNS	_	6	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	16	nmod	_	_
13	the	the	DT	DT	_	15	det	_	_
14	c-Jun	c-jun	NN	NN	_	15	compound	_	_
15	delta-domain	delta-domain	NN	NN	_	16	nsubj	_	_
16	functions	function	VBZ	VBZ	_	10	acl:relcl	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	modulatory	modulatory	JJ	JJ	_	20	amod	_	_
20	switch	switch	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	3	cc	_	_
22	further	further	RB	RB	_	23	advmod	_	_
23	imply	imply	VBP	VBP	_	3	conj	_	_
24	that	that	IN	IN	_	31	mark	_	_
25	the	the	DT	DT	_	27	det	_	_
26	functional	functional	JJ	JJ	_	27	amod	_	_
27	role	role	NN	NN	_	31	nsubjpass	_	_
28	of	of	IN	IN	_	29	case	_	_
29	c-Jun	c-jun	NN	NN	_	27	nmod	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	dictated	dictate	VBN	VBN	_	23	ccomp	_	_
32	by	by	IN	IN	_	34	case	_	_
33	cell-specific	cell-specific	JJ	JJ	_	34	amod	_	_
34	influences	influence	NNS	NNS	_	31	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	the	the	DT	DT	_	38	det	_	_
37	delta-domain	delta-domain	JJ	JJ	_	38	amod	_	_
38	motif	motif	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	BCL-6	bcl-6	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	POZ/zinc-finger	poz/zinc-finger	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	sequence-specific	sequence-specific	JJ	JJ	_	11	amod	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	repressor	repressor	NN	NN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Approximately	approximately	RB	RB	_	2	advmod	_	_
2	40	40	CD	CD	_	3	nummod	_	_
3	%	%	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	diffuse	diffuse	JJ	JJ	_	8	amod	_	_
6	large	large	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lymphoma	lymphoma	NN	NN	_	3	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	chromosomal	chromosomal	JJ	JJ	_	13	amod	_	_
13	translocations	translocation	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	deregulate	deregulate	VBP	VBP	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	BCL6	bcl6	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	juxtaposing	juxtapose	VBG	VBG	_	15	advcl	_	_
24	heterologous	heterologous	JJ	JJ	_	25	amod	_	_
25	promoters	promoter	NNS	NNS	_	23	dobj	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	BCL-6	bcl-6	NN	NN	_	30	compound	_	_
29	coding	coding	NN	NN	_	30	compound	_	_
30	domain	domain	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	BCL6	bcl6	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	95-kDa	95-kda	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	4	dobj	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	six	six	CD	CD	_	12	nummod	_	_
10	C-terminal	c-terminal	JJ	JJ	_	12	amod	_	_
11	zinc-finger	zinc-finger	NN	NN	_	12	compound	_	_
12	motifs	motif	NNS	NNS	_	8	dobj	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	an	a	DT	DT	_	17	det	_	_
15	N-terminal	n-terminal	JJ	JJ	_	17	amod	_	_
16	POZ	poz	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	7	conj	_	_
18	,	,	,	,	_	4	punct	_	_
19	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	function	function	VB	VB	_	19	ccomp	_	_
24	as	as	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	18	advcl	_	_
3	a	a	DT	DT	_	5	det	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	2	dobj	_	_
6	selected	select	VBN	VBN	_	5	acl	_	_
7	for	for	IN	IN	_	9	case	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	ability	ability	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	bind	bind	VB	VB	_	9	acl	_	_
12	recombinant	recombinant	JJ	JJ	_	13	amod	_	_
13	BCL-6	bcl-6	NN	NN	_	11	dobj	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	11	advmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	show	show	VBP	VBP	_	0	root	_	_
19	here	here	RB	RB	_	18	advmod	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	BCL-6	bcl-6	NN	NN	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	present	present	JJ	JJ	_	18	ccomp	_	_
24	in	in	IN	IN	_	26	case	_	_
25	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
26	complexes	complex	NNS	NNS	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	extracts	extract	NNS	NNS	_	26	nmod	_	_
30	from	from	IN	IN	_	33	case	_	_
31	various	various	JJ	JJ	_	33	amod	_	_
32	B-cell	b-cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	transfectin	transfectin	NN	NN	_	4	compound	_	_
4	experiments	experiment	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	BCL6	bcl6	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	repress	repress	VB	VB	_	0	root	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	from	from	IN	IN	_	11	case	_	_
11	promoters	promoter	NNS	NNS	_	9	nmod	_	_
12	linked	link	VBN	VBN	_	11	acl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	target	target	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	this	this	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	dependent	dependent	JJ	JJ	_	8	conj	_	_
23	upon	upon	IN	IN	_	25	case	_	_
24	specific	specific	JJ	JJ	_	25	amod	_	_
25	DNA-binding	dna-binding	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	28	det	_	_
28	presence	presence	NN	NN	_	25	conj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	an	a	DT	DT	_	33	det	_	_
31	intact	intact	JJ	JJ	_	33	amod	_	_
32	N-terminal	n-terminal	JJ	JJ	_	33	amod	_	_
33	half	half	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	protein	protein	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	this	this	DT	DT	_	5	det	_	_
5	part	part	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	BCL6	bcl6	NN	NN	_	9	compound	_	_
9	molecule	molecule	NN	NN	_	5	nmod	_	_
10	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
11	an	a	DT	DT	_	14	det	_	_
12	autonomous	autonomous	JJ	JJ	_	14	amod	_	_
13	transrepressor	transrepressor	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	10	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	that	that	IN	IN	_	26	mark	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	noncontiguous	noncontiguous	JJ	JJ	_	19	amod	_	_
19	regions	region	NNS	NNS	_	26	nsubj	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	POZ	poz	NN	NN	_	24	compound	_	_
24	motif	motif	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	mediate	mediate	VBP	VBP	_	10	conj	_	_
27	maximum	maximum	JJ	JJ	_	29	amod	_	_
28	transrepressive	transrepressive	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	BCL-6	bcl-6	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	function	function	VB	VB	_	3	ccomp	_	_
10	as	as	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	sequence-specific	sequence-specific	JJ	JJ	_	14	amod	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	repressor	repressor	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	have	have	VBP	VBP	_	3	conj	_	_
17	implications	implication	NNS	NNS	_	16	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	role	role	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	BCL6	bcl6	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	normal	normal	JJ	JJ	_	26	amod	_	_
25	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
26	development	development	NN	NN	_	20	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	lymphomagenesis	lymphomagenesis	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	specific	specific	JJ	JJ	_	6	amod	_	_
5	interferon	interferon	NN	NN	_	6	compound	_	_
6	isotypes	isotype	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	individuals	individual	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	in	in	IN	IN	_	18	case	_	_
16	promonocytic	promonocytic	JJ	JJ	_	18	amod	_	_
17	U937	u937	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IFN-alpha5	ifn-alpha5	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-beta	ifn-beta	NN	NN	_	4	conj	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	including	include	VBG	VBG	_	17	case	_	_
14	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
15	blood	blood	NN	NN	_	17	compound	_	_
16	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	normal	normal	JJ	JJ	_	20	amod	_	_
20	individuals	individual	NNS	NNS	_	17	nmod	_	_
21	following	follow	VBG	VBG	_	22	case	_	_
22	amplification	amplification	NN	NN	_	8	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	IFN	ifn	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	22	nmod	_	_
26	by	by	IN	IN	_	30	case	_	_
27	reverse	reverse	JJ	JJ	_	30	amod	_	_
28	transcriptase-polymerase	transcriptase-polymerase	NN	NN	_	30	compound	_	_
29	chain	chain	NN	NN	_	30	compound	_	_
30	reaction	reaction	NN	NN	_	22	nmod	_	_
31	and	and	CC	CC	_	22	cc	_	_
32	direct	direct	JJ	JJ	_	33	amod	_	_
33	sequencing	sequencing	NN	NN	_	22	conj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	amplified	amplify	VBN	VBN	_	37	amod	_	_
37	product	product	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	activated	activated	JJ	JJ	_	3	amod	_	_
3	form	form	NN	NN	_	13	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	interferon-induced	interferon-induced	JJ	JJ	_	10	amod	_	_
7	transcription	transcription	NN	NN	_	10	compound	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	complex	complex	NN	NN	_	10	compound	_	_
10	ISGF3	isgf3	NN	NN	_	3	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	detected	detect	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	extracts	extract	NNS	NNS	_	13	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	uninduced	uninduced	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Culture	culture	NN	NN	_	2	compound	_	_
2	supernatants	supernatant	NNS	NNS	_	9	nsubjpass	_	_
3	from	from	IN	IN	_	6	case	_	_
4	uninduced	uninduced	JJ	JJ	_	6	amod	_	_
5	U937	u937	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	activate	activate	VB	VB	_	9	xcomp	_	_
12	an	a	DT	DT	_	13	det	_	_
13	ISRE	isre	NN	NN	_	11	dobj	_	_
14	cloned	clone	VBN	VBN	_	13	acl	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	luciferase	luciferase	NN	NN	_	20	compound	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	11	punct	_	_
22	indicating	indicate	VBG	VBG	_	11	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	presence	presence	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	endogenous	endogenous	JJ	JJ	_	28	amod	_	_
27	IFN	ifn	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	24	nmod	_	_
29	equivalent	equivalent	JJ	JJ	_	28	amod	_	_
30	to	to	TO	TO	_	35	case	_	_
31	approximately	approximately	RB	RB	_	34	advmod	_	_
32	0.3	0.3	CD	CD	_	34	compound	_	_
33	to	to	TO	TO	_	34	dep	_	_
34	0.5	0.5	CD	CD	_	35	nummod	_	_
35	IU/mL	iu/ml	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	endogenous	endogenous	JJ	JJ	_	3	amod	_	_
3	IFN	ifn	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	play	play	VB	VB	_	6	xcomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	maintaining	maintain	VBG	VBG	_	8	advcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	basal	basal	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	expression	expression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	major	major	JJ	JJ	_	24	amod	_	_
21	histocompatibility	histocompatibility	NN	NN	_	24	compound	_	_
22	class	class	NN	NN	_	24	compound	_	_
23	I	i	CD	CD	_	24	nummod	_	_
24	genes	gene	NNS	NNS	_	17	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	lymphoid	lymphoid	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	17	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	IFN-alpha5	ifn-alpha5	NN	NN	_	9	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IFN-beta	ifn-beta	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	produced	produce	VBN	VBN	_	3	ccomp	_	_
10	at	at	IN	IN	_	12	case	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	normal	normal	JJ	JJ	_	15	amod	_	_
15	tissues	tissue	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	play	play	VBP	VBP	_	9	conj	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	function	function	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	maintenance	maintenance	NN	NN	_	23	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	homeostasis	homeostasis	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Gene	gene	NN	NN	_	2	compound	_	_
2	transcription	transcription	NN	NN	_	0	root	_	_
3	through	through	IN	IN	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	G-protein-coupled	g-protein-coupled	JJ	JJ	_	8	amod	_	_
7	chemoattractant	chemoattractant	NN	NN	_	8	compound	_	_
8	receptors	receptor	NNS	NNS	_	4	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Receptors	receptor	NNS	NNS	_	11	nsubjpass	_	_
2	for	for	IN	IN	_	4	case	_	_
3	leukocyte	leukocyte	JJ	JJ	_	4	amod	_	_
4	chemoattractants	chemoattractant	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	including	include	VBG	VBG	_	7	case	_	_
7	chemokines	chemokine	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	traditionally	traditionally	RB	RB	_	11	advmod	_	_
11	considered	consider	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	responsible	responsible	JJ	JJ	_	11	xcomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	special	special	JJ	JJ	_	21	amod	_	_
20	leukocyte	leukocyte	JJ	JJ	_	21	amod	_	_
21	functions	function	NNS	NNS	_	17	nmod	_	_
22	such	such	JJ	JJ	_	24	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	chemotaxis	chemotaxis	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	degranulation	degranulation	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	release	release	NN	NN	_	24	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	superoxide	superoxide	NN	NN	_	33	compound	_	_
33	anions	anion	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	Recently	recently	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	these	these	DT	DT	_	6	det	_	_
4	G-protein-coupled	g-protein-coupled	JJ	JJ	_	6	amod	_	_
5	serpentine	serpentine	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	9	nsubjpass	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	transduce	transduce	VB	VB	_	9	xcomp	_	_
12	signals	signal	NNS	NNS	_	11	dobj	_	_
13	leading	lead	VBG	VBG	_	12	acl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	gene	gene	NN	NN	_	13	nmod	_	_
16	transcription	transcription	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	translation	translation	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	leukocytes	leukocyte	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	13	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	such	such	JJ	JJ	_	8	case	_	_
5	as	as	IN	IN	_	4	mwe	_	_
6	NF	nf	NN	NN	_	8	compound	_	_
7	kappa	kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-1	ap-1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	activated	activate	VBN	VBN	_	0	root	_	_
14	upon	upon	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	several	several	JJ	JJ	_	21	amod	_	_
21	chemoattractants	chemoattractant	NNS	NNS	_	15	nmod	_	_
22	at	at	IN	IN	_	25	case	_	_
23	physiologically	physiologically	RB	RB	_	24	advmod	_	_
24	relevant	relevant	JJ	JJ	_	25	amod	_	_
25	concentrations	concentration	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	through	through	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	receptors	receptor	NNS	NNS	_	1	nmod	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	G-protein	g-protein	NN	NN	_	10	compound	_	_
10	coupling	coupling	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activation	activation	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	kinases	kinase	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	underlying	underlying	JJ	JJ	_	4	amod	_	_
3	signaling	signaling	NN	NN	_	4	compound	_	_
4	pathways	pathway	NNS	NNS	_	5	nsubj	_	_
5	appear	appear	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	different	different	JJ	JJ	_	5	xcomp	_	_
9	from	from	IN	IN	_	10	case	_	_
10	those	those	DT	DT	_	8	nmod	_	_
11	utilized	utilize	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	18	det	_	_
16	better	better	RBR	RBR	_	17	advmod	_	_
17	characterized	characterize	VBN	VBN	_	18	amod	_	_
18	cytokine	cytokine	NN	NN	_	13	appos	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	induces	induce	VBZ	VBZ	_	18	acl:relcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	transcription	transcription	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	immediate-early	immediate-early	JJ	JJ	_	25	amod	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Chemoattractants	chemoattractant	NNS	NNS	_	2	nsubj	_	_
2	stimulate	stimulate	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	several	several	JJ	JJ	_	8	amod	_	_
7	inflammatory	inflammatory	JJ	JJ	_	8	amod	_	_
8	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	chemokines	chemokine	NNS	NNS	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	which	which	WDT	WDT	_	16	nsubj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	turn	turn	NN	NN	_	16	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	activate	activate	VB	VB	_	8	acl:relcl	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	respective	respective	JJ	JJ	_	19	amod	_	_
19	receptors	receptor	NNS	NNS	_	16	dobj	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	initiate	initiate	VB	VB	_	16	conj	_	_
22	an	a	DT	DT	_	25	det	_	_
23	autocrine	autocrine	JJ	JJ	_	25	amod	_	_
24	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
25	mechanism	mechanism	NN	NN	_	21	dobj	_	_
26	for	for	IN	IN	_	32	case	_	_
27	persistent	persistent	JJ	JJ	_	32	amod	_	_
28	cytokine	cytokine	NN	NN	_	32	compound	_	_
29	and	and	CC	CC	_	32	cc	_	_
30	chemokine	chemokine	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Mechanisms	mechanism	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	transactivation	transactivation	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells-1	cells-1	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	7	compound	_	_
3	of	of	IN	IN	_	6	case	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells-family	cells-family	NN	NN	_	2	nmod	_	_
7	proteins	protein	NNS	NNS	_	18	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NFAT1/NFATp	nfat1/nfatp	NN	NN	_	7	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	NFATc	nfatc	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	NFAT3	nfat3	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	NFAT4/NFATx/NFATc3	nfat4/nfatx/nfatc3	NN	NN	_	9	conj	_	_
17	)	)	-RRB-	-RRB-	_	9	punct	_	_
18	play	play	VBP	VBP	_	0	root	_	_
19	a	a	DT	DT	_	21	det	_	_
20	key	key	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	transcription	transcription	NN	NN	_	18	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	cytokine	cytokine	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	other	other	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	27	conj	_	_
31	during	during	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	immune	immune	JJ	JJ	_	34	amod	_	_
34	response	response	NN	NN	_	18	nmod	_	_
35	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	defined	define	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	transactivation	transactivation	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	NFAT1	nfat1	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	NFAT1	NFAT1	NNP	NNP	_	2	nsubj	_	_
2	possesses	possess	VBZ	VBZ	_	0	root	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	transactivation	transactivation	NN	NN	_	5	compound	_	_
5	domains	domain	NNS	NNS	_	2	dobj	_	_
6	whose	whose	WP$	WP$	_	7	nmod:poss	_	_
7	sequences	sequence	NNS	NNS	_	10	nsubjpass	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	conserved	conserve	VBN	VBN	_	5	acl:relcl	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	other	other	JJ	JJ	_	15	amod	_	_
14	NFAT-family	nfat-family	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	a	a	DT	DT	_	21	det	_	_
19	conserved	conserve	VBN	VBN	_	21	amod	_	_
20	DNA-binding	dna-binding	JJ	JJ	_	21	amod	_	_
21	domain	domain	NN	NN	_	5	conj	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	mediates	mediate	VBZ	VBZ	_	21	acl:relcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	recruitment	recruitment	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	cooperating	cooperate	VBG	VBG	_	30	amod	_	_
28	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	25	nmod	_	_
31	even	even	RB	RB	_	32	advmod	_	_
32	when	when	WRB	WRB	_	35	advmod	_	_
33	it	it	PRP	PRP	_	35	nsubjpass	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	expressed	express	VBN	VBN	_	2	advcl	_	_
36	in	in	IN	IN	_	41	case	_	_
37	the	the	DT	DT	_	41	dep	_	_
38	absence	absence	NN	NN	_	41	dep	_	_
39	of	of	IN	IN	_	41	case	_	_
40	other	other	JJ	JJ	_	41	amod	_	_
41	regions	region	NNS	NNS	_	35	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	protein	protein	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	NH2-terminal	nh2-terminal	JJ	JJ	_	7	amod	_	_
6	transactivation	transactivation	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	modulated	modulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	adjacent	adjacent	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	9	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	contains	contain	VBZ	VBZ	_	14	acl:relcl	_	_
17	several	several	JJ	JJ	_	20	amod	_	_
18	conserved	conserve	VBN	VBN	_	20	amod	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	motifs	motif	NNS	NNS	_	16	dobj	_	_
21	represented	represent	VBN	VBN	_	20	acl	_	_
22	only	only	RB	RB	_	26	advmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	NFAT	nfat	NN	NN	_	26	compound	_	_
26	family	family	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	emphasize	emphasize	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	multiple	multiple	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	dobj	_	_
7	at	at	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	12	nmod	_	_
9	NFAT-dependent	nfat-dependent	JJ	JJ	_	10	amod	_	_
10	transactivation	transactivation	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	6	acl:relcl	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	predict	predict	VBP	VBP	_	3	conj	_	_
16	significant	significant	JJ	JJ	_	17	amod	_	_
17	differences	difference	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	architecture	architecture	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	cooperative	cooperative	JJ	JJ	_	24	amod	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	complexes	complex	NNS	NNS	_	20	nmod	_	_
25	containing	contain	VBG	VBG	_	24	acl	_	_
26	different	different	JJ	JJ	_	28	amod	_	_
27	NFAT-family	nfat-family	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	25	dobj	_	_
29	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Ets	ets	NN	NN	_	4	compound	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	Spi-B	spi-b	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	exclusively	exclusively	RB	RB	_	10	advmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	during	during	IN	IN	_	15	case	_	_
15	development	development	NN	NN	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Spi-B	spi-b	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	PU.1	pu.1	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	7	cop	_	_
5	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	constitute	constitute	VBP	VBP	_	7	acl:relcl	_	_
10	a	a	DT	DT	_	11	det	_	_
11	subfamily	subfamily	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Ets	ets	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	contrary	contrary	JJ	JJ	_	8	case	_	_
6	to	to	TO	TO	_	8	case	_	_
7	previous	previous	JJ	JJ	_	8	amod	_	_
8	reports	report	NNS	NNS	_	13	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	PU.1	pu.1	NN	NN	_	13	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Spi-B	spi-b	NN	NN	_	10	conj	_	_
13	have	have	VBP	VBP	_	3	ccomp	_	_
14	very	very	RB	RB	_	15	advmod	_	_
15	different	different	JJ	JJ	_	17	amod	_	_
16	expression	expression	NN	NN	_	17	compound	_	_
17	patterns	pattern	NNS	NNS	_	13	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	PU.1	pu.1	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	mast	mast	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	megakaryocytes	megakaryocyte	NNS	NNS	_	9	conj	_	_
15	,	,	,	,	_	9	punct	_	_
16	macrophages	macrophage	NNS	NNS	_	9	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	neutrophils	neutrophil	NNS	NNS	_	9	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	immature	immature	JJ	JJ	_	23	amod	_	_
22	erythroid	erythroid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	9	conj	_	_
24	and	and	CC	CC	_	3	cc	_	_
25	at	at	IN	IN	_	27	case	_	_
26	lower	lower	JJR	JJR	_	27	amod	_	_
27	levels	level	NNS	NNS	_	3	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	mature	mature	JJ	JJ	_	30	amod	_	_
30	erythrocytes	erythrocyte	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	PU.1	pu.1	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	completely	completely	RB	RB	_	4	advmod	_	_
4	absent	absent	JJ	JJ	_	0	root	_	_
5	from	from	IN	IN	_	8	case	_	_
6	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	most	most	JJS	JJS	_	13	amod	_	_
11	T	t	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	8	conj	_	_
14	based	base	VBN	VBN	_	18	case	_	_
15	on	on	IN	IN	_	18	case	_	_
16	sensitive	sensitive	JJ	JJ	_	18	amod	_	_
17	RT-PCR	rt-pcr	NN	NN	_	18	compound	_	_
18	assays	assay	NNS	NNS	_	4	advcl	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	Spi-B	spi-b	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	exclusively	exclusively	RB	RB	_	6	advmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	lymphoid	lymphoid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	6	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	early	early	JJ	JJ	_	18	amod	_	_
17	fetal	fetal	JJ	JJ	_	18	amod	_	_
18	thymus	thymus	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	spleen	spleen	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	hybridizations	hybridization	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	adult	adult	JJ	JJ	_	7	amod	_	_
6	murine	murine	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	3	nmod	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	Spi-B	spi-b	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	medulla	medulla	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	thymus	thymus	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	the	the	DT	DT	_	20	det	_	_
19	white	white	JJ	JJ	_	20	amod	_	_
20	pulp	pulp	NN	NN	_	13	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	spleen	spleen	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	germinal	germinal	JJ	JJ	_	28	amod	_	_
28	centers	center	NNS	NNS	_	13	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	lymph	lymph	NN	NN	_	31	compound	_	_
31	nodes	node	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Spi-B	spi-b	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	very	very	RB	RB	_	5	advmod	_	_
5	abundant	abundant	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	Spi-B	spi-b	NN	NN	_	16	nsubjpass	_	_
12	mRNA	mrna	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	protein	protein	NN	NN	_	12	conj	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	detected	detect	VBN	VBN	_	5	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	some	some	DT	DT	_	20	det	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	hybridization	hybridization	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Northern	northern	NN	NN	_	7	compound	_	_
6	blot	blot	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	3	conj	_	_
8	suggest	suggest	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	Spi-B	spi-b	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	13	nsubj	_	_
13	increases	increase	VBZ	VBZ	_	8	ccomp	_	_
14	during	during	IN	IN	_	17	case	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	maturation	maturation	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	decreases	decrease	VBZ	VBZ	_	13	conj	_	_
20	during	during	IN	IN	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	maturation	maturation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Gel-retardation	gel-retardation	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Spi-B	spi-b	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	bind	bind	VB	VB	_	3	ccomp	_	_
8	to	to	TO	TO	_	13	case	_	_
9	all	all	DT	DT	_	13	det	_	_
10	putative	putative	JJ	JJ	_	13	amod	_	_
11	PU.1	pu.1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	7	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	but	but	CC	CC	_	3	cc	_	_
16	do	do	VBP	VBP	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	reveal	reveal	VB	VB	_	3	conj	_	_
19	any	any	DT	DT	_	23	det	_	_
20	preferred	preferred	JJ	JJ	_	23	amod	_	_
21	Spi-B	spi-b	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	18	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	PU.1	pu.1	NN	NN	_	7	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Spi-B	spi-b	NN	NN	_	4	conj	_	_
7	function	function	VBP	VBP	_	0	root	_	_
8	as	as	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activators	activator	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	immunoglobulin	immunoglobulin	JJ	JJ	_	17	amod	_	_
14	light-chain	light-chain	NN	NN	_	17	compound	_	_
15	enhancer	enhancer	NN	NN	_	17	compound	_	_
16	E	e	NN	NN	_	17	compound	_	_
17	lambda	lambda	NN	NN	_	10	nmod	_	_
18	2.4	2.4	CD	CD	_	17	nummod	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	coexpressed	coexpress	VBN	VBN	_	7	advcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	Pip	pip	NN	NN	_	20	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	PU.1-interaction	pu.1-interaction	JJ	JJ	_	25	amod	_	_
25	partner	partner	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	29	case	_	_
28	NIH-3T3	nih-3t3	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	20	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	differences	difference	NNS	NNS	_	17	nsubj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	patterns	pattern	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	between	between	IN	IN	_	14	case	_	_
14	Spi-B	spi-b	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	PU.1	pu.1	NN	NN	_	14	conj	_	_
17	distinguish	distinguish	VBP	VBP	_	6	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	function	function	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	each	each	DT	DT	_	22	det	_	_
22	protein	protein	NN	NN	_	19	nmod	_	_
23	during	during	IN	IN	_	24	case	_	_
24	development	development	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	factor-kappa	factor-kappa	NN	NN	_	5	compound	_	_
5	B/Rel	b/rel	NN	NN	_	7	compound	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	2	dobj	_	_
8	in	in	IN	IN	_	13	case	_	_
9	CD3-stimulated	cd3-stimulated	JJ	JJ	_	13	amod	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	IL-10	il-10	NN	NN	_	3	nsubj	_	_
2	markedly	markedly	RB	RB	_	3	advmod	_	_
3	reduces	reduce	VBZ	VBZ	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
5	factor	factor	NN	NN	_	12	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	NF	nf	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	-kappa	-kappa	NN	NN	_	10	compound	_	_
10	B/Rel	b/rel	NN	NN	_	12	compound	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	3	dobj	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	PBMC	pbmc	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	stimulation	stimulation	NN	NN	_	13	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	anti-CD3	anti-cd3	JJ	JJ	_	21	amod	_	_
21	mAb	mab	NN	NN	_	17	nmod	_	_
22	OKT3	okt3	NN	NN	_	21	dep	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	exerted	exert	VBN	VBN	_	0	root	_	_
5	specifically	specifically	RB	RB	_	10	advmod	_	_
6	on	on	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B/Rel	b/rel	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	4	nmod	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	mAb	mab	NN	NN	_	14	compound	_	_
14	OKT3	okt3	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	that	that	DT	DT	_	10	conj	_	_
19	produced	produce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	PMA	pma	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	judged	judge	VBN	VBN	_	33	advcl	_	_
3	by	by	IN	IN	_	4	mark	_	_
4	supershifting	supershift	VBG	VBG	_	2	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DNA-protein	dna-protein	JJ	JJ	_	7	amod	_	_
7	complexes	complex	NNS	NNS	_	4	dobj	_	_
8	with	with	IN	IN	_	9	case	_	_
9	Abs	abs	NN	NN	_	7	nmod	_	_
10	recognizing	recognize	VBG	VBG	_	9	acl	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	components	component	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B/Rel	b/rel	NN	NN	_	18	compound	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	family	family	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	33	punct	_	_
20	the	the	DT	DT	_	27	det	_	_
21	p50/p65	p50/p65	NN	NN	_	27	compound	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	Rel	rel	NN	NN	_	24	compound	_	_
24	A	a	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	heterodimeric	heterodimeric	JJ	JJ	_	27	amod	_	_
27	form	form	NN	NN	_	33	nsubjpass	_	_
28	of	of	IN	IN	_	30	case	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	nmod	_	_
31	is	be	VBZ	VBZ	_	33	auxpass	_	_
32	primarily	primarily	RB	RB	_	33	advmod	_	_
33	affected	affect	VBN	VBN	_	0	root	_	_
34	.	.	.	.	_	33	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	maximal	maximal	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-10	il-10	NN	NN	_	9	compound	_	_
9	concentration	concentration	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	20	20	CD	CD	_	12	nummod	_	_
12	U/ml	u/ml	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	IL-10	il-10	NN	NN	_	3	compound	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	exerted	exert	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	5	conj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Indeed	indeed	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	monocytes	monocyte	NNS	NNS	_	8	nsubj	_	_
4	pretreated	pretreat	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IL-10	il-10	NN	NN	_	4	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	able	able	JJ	JJ	_	0	root	_	_
9	so	so	RB	RB	_	10	advmod	_	_
10	inhibit	inhibit	VBP	VBP	_	8	dep	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	purified	purify	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
19	stimulated	stimulate	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	OKT3	okt3	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Soluble	soluble	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	5	nsubj	_	_
3	do	do	VBP	VBP	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	appear	appear	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	5	xcomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mechanism	mechanism	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	inhibition	inhibition	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	24	nmod	_	_
5	,	,	,	,	_	24	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	up-regulation	up-regulation	NN	NN	_	24	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CD80	cd80	NN	NN	_	10	compound	_	_
10	Ag	ag	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	found	find	VBN	VBN	_	10	acl	_	_
13	on	on	IN	IN	_	14	case	_	_
14	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
15	obtained	obtain	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	17	case	_	_
17	PBMC	pbmc	NN	NN	_	15	nmod	_	_
18	incubated	incubate	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	20	case	_	_
20	OKT3	okt3	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	7	punct	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	detected	detect	VBN	VBN	_	0	root	_	_
25	after	after	IN	IN	_	26	case	_	_
26	addition	addition	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-10	il-10	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	anti-CD28	anti-cd28	JJ	JJ	_	33	amod	_	_
33	mAb	mab	NN	NN	_	35	nsubj	_	_
34	CLB-CD28/1	clb-cd28/1	NN	NN	_	33	dep	_	_
35	restores	restore	VBZ	VBZ	_	24	conj	_	_
36	the	the	DT	DT	_	40	det	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B/Rel	b/rel	NN	NN	_	40	compound	_	_
39	nuclear	nuclear	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	35	dobj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	IL-10-inhibited	il-10-inhibited	JJ	JJ	_	43	amod	_	_
43	lymphocytes	lymphocyte	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	24	punct	_	_

1	Therefore	therefore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B/Rel	b/rel	NN	NN	_	6	compound	_	_
6	inhibition	inhibition	NN	NN	_	9	nsubjpass	_	_
7	might	might	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	ascribed	ascribe	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	lack	lack	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	cooperation	cooperation	NN	NN	_	12	nmod	_	_
15	between	between	IN	IN	_	17	case	_	_
16	accessory	accessory	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	17	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	resulting	result	VBG	VBG	_	12	acl	_	_
23	from	from	IN	IN	_	24	case	_	_
24	down-regulation	down-regulation	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	costimulatory	costimulatory	JJ	JJ	_	28	amod	_	_
28	molecule	molecule	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	such	such	JJ	JJ	_	32	case	_	_
31	as	as	IN	IN	_	30	mwe	_	_
32	CD80	cd80	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	produced	produce	VBN	VBN	_	32	acl	_	_
35	by	by	IN	IN	_	36	case	_	_
36	IL-10	il-10	NN	NN	_	34	nmod	_	_
37	on	on	IN	IN	_	39	case	_	_
38	activated	activate	VBN	VBN	_	39	amod	_	_
39	monocytes	monocyte	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IL-10	il-10	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	inhibit	inhibit	VB	VB	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B/Rel	b/rel	NN	NN	_	14	compound	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	CD3-stimulated	cd3-stimulated	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	8	mark	_	_
2	inappropriate	inappropriate	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	kappa	kappa	NN	NN	_	7	compound	_	_
6	B-driven	b-driven	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	3	nmod	_	_
8	has	have	VBZ	VBZ	_	25	advcl	_	_
9	a	a	DT	DT	_	11	det	_	_
10	physiopathologic	physiopathologic	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	diseases	disease	NNS	NNS	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	such	such	JJ	JJ	_	21	case	_	_
19	as	as	IN	IN	_	18	mwe	_	_
20	HIV	hiv	NN	NN	_	21	compound	_	_
21	infection	infection	NN	NN	_	14	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	our	we	PRP$	PRP$	_	24	nmod:poss	_	_
24	findings	finding	NNS	NNS	_	25	nsubj	_	_
25	support	support	VBP	VBP	_	0	root	_	_
26	the	the	DT	DT	_	27	det	_	_
27	possibility	possibility	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	mark	_	_
29	using	use	VBG	VBG	_	27	acl	_	_
30	this	this	DT	DT	_	31	det	_	_
31	cytokine	cytokine	NN	NN	_	29	dobj	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	suppress	suppress	VB	VB	_	29	advcl	_	_
34	an	a	DT	DT	_	36	det	_	_
35	undesirable	undesirable	JJ	JJ	_	36	amod	_	_
36	activation	activation	NN	NN	_	33	dobj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	these	these	DT	DT	_	40	det	_	_
39	transcription	transcription	NN	NN	_	40	compound	_	_
40	factors	factor	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	25	punct	_	_

1	Precise	precise	JJ	JJ	_	2	amod	_	_
2	alignment	alignment	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	sites	site	NNS	NNS	_	2	nmod	_	_
5	required	require	VBN	VBN	_	2	acl	_	_
6	for	for	IN	IN	_	9	case	_	_
7	mu	mu	NN	NN	_	9	compound	_	_
8	enhancer	enhancer	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	8	amod	_	_
3	immunoglobulin	immunoglobulin	NN	NN	_	8	compound	_	_
4	mu	mu	NN	NN	_	8	compound	_	_
5	heavy-chain	heavy-chain	JJ	JJ	_	8	amod	_	_
6	gene	gene	NN	NN	_	8	compound	_	_
7	intronic	intronic	JJ	JJ	_	8	amod	_	_
8	enhancer	enhancer	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	regulated	regulate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	multiple	multiple	JJ	JJ	_	14	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	defined	define	VBN	VBN	_	5	amod	_	_
4	minimal	minimal	JJ	JJ	_	5	amod	_	_
5	enhancer	enhancer	NN	NN	_	16	nsubjpass	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	14	det	_	_
8	muA	mua	NN	NN	_	14	compound	_	_
9	,	,	,	,	_	8	punct	_	_
10	muE3	mue3	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	muB	mub	NN	NN	_	8	conj	_	_
14	sites	site	NNS	NNS	_	6	dobj	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	transactivated	transactivate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	combination	combination	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	ETS-domain	ets-domain	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	19	nmod	_	_
24	PU.1	pu.1	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Ets-1	ets-1	NN	NN	_	24	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	nonlymphoid	nonlymphoid	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	core	core	NN	NN	_	3	compound	_	_
3	GGAAs	ggaa	NNS	NNS	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	muA	mua	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	muB	mub	NN	NN	_	6	conj	_	_
9	sites	site	NNS	NNS	_	3	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	separated	separate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	30	30	CD	CD	_	14	nummod	_	_
14	nucleotides	nucleotide	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	ETS	et	NNS	NNS	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	20	nsubj	_	_
20	bind	bind	VBP	VBP	_	16	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	sites	site	NNS	NNS	_	20	nmod	_	_
24	from	from	IN	IN	_	27	case	_	_
25	these	these	DT	DT	_	27	det	_	_
26	same	same	JJ	JJ	_	27	amod	_	_
27	side	side	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	DNA	dna	NN	NN	_	31	compound	_	_
31	helix	helix	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	tested	test	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	necessity	necessity	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	8	case	_	_
6	appropriate	appropriate	JJ	JJ	_	8	amod	_	_
7	spatial	spatial	JJ	JJ	_	8	amod	_	_
8	alignment	alignment	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	elements	element	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	using	use	VBG	VBG	_	2	advcl	_	_
14	mutated	mutate	VBN	VBN	_	15	amod	_	_
15	enhancers	enhancer	NNS	NNS	_	13	dobj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	altered	altered	JJ	JJ	_	18	amod	_	_
18	spacings	spacing	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	4-	4-	CD	CD	_	5	amod	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	10-bp	10-bp	JJ	JJ	_	2	conj	_	_
5	insertion	insertion	NN	NN	_	10	nsubj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	muE3	mue3	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	muB	mub	NN	NN	_	7	conj	_	_
10	inactivated	inactivate	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	mu	mu	NN	NN	_	13	compound	_	_
13	enhancer	enhancer	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	S194	s194	NN	NN	_	17	compound	_	_
16	plasma	plasma	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	but	but	CC	CC	_	10	cc	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	affect	affect	VB	VB	_	10	conj	_	_
22	in	in	FW	FW	_	24	amod	_	_
23	vitro	vitro	FW	FW	_	22	dep	_	_
24	binding	binding	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Ets-1	ets-1	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	PU.1	pu.1	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	or	or	CC	CC	_	26	cc	_	_
31	the	the	DT	DT	_	34	det	_	_
32	muE3-binding	mue3-binding	JJ	JJ	_	34	amod	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	TFE3	tfe3	NN	NN	_	26	conj	_	_
35	,	,	,	,	_	21	punct	_	_
36	alone	alone	RB	RB	_	37	advmod	_	_
37	or	or	CC	CC	_	21	advmod	_	_
38	in	in	IN	IN	_	40	case	_	_
39	pairwise	pairwise	JJ	JJ	_	40	amod	_	_
40	combinations	combination	NNS	NNS	_	37	conj	_	_
41	.	.	.	.	_	10	punct	_	_

1	Circular	circular	JJ	JJ	_	2	amod	_	_
2	permutation	permutation	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	phasing	phasing	NN	NN	_	2	conj	_	_
5	analyses	analysis	NNS	NNS	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	PU.1	pu.1	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	15	nsubj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	TFE3	tfe3	NN	NN	_	9	conj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	Ets-1	ets-1	NN	NN	_	12	conj	_	_
15	bends	bend	VBZ	VBZ	_	6	ccomp	_	_
16	mu	mu	NN	NN	_	18	compound	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	DNA	dna	NN	NN	_	15	dobj	_	_
19	toward	toward	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	major	major	JJ	JJ	_	22	amod	_	_
22	groove	groove	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	23	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	requirement	requirement	NN	NN	_	23	nsubj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	precise	precise	JJ	JJ	_	8	amod	_	_
8	spacing	spacing	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	muA	mua	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	muB	mub	NN	NN	_	11	conj	_	_
14	elements	element	NNS	NNS	_	8	nmod	_	_
15	is	be	VBZ	VBZ	_	23	cop	_	_
16	due	due	JJ	JJ	_	23	case	_	_
17	in	in	IN	IN	_	18	case	_	_
18	part	part	NN	NN	_	23	nmod	_	_
19	to	to	TO	TO	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	directed	directed	JJ	JJ	_	23	amod	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	bend	bend	NN	NN	_	2	ccomp	_	_
24	induced	induce	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	PU.1	pu.1	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	activators	activator	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	replication	replication	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	proviral	proviral	JJ	JJ	_	10	amod	_	_
10	induction	induction	NN	NN	_	7	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	13	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	C/EBP	c/ebp	NN	NN	_	11	compound	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activators	activator	NNS	NNS	_	7	conj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	necessary	necessary	JJ	JJ	_	4	ccomp	_	_
14	for	for	IN	IN	_	17	case	_	_
15	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
16	LTR	ltr	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	that	that	WDT	WDT	_	9	dobj	_	_
7	C/EBP	c/ebp	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	9	nsubj	_	_
9	play	play	VBP	VBP	_	5	acl:relcl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	induction	induction	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	replication	replication	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	HIV-1	hiv-1	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Ectopic	ectopic	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	dominant	dominant	JJ	JJ	_	9	amod	_	_
6	negative	negative	JJ	JJ	_	9	amod	_	_
7	C/EBP	c/ebp	NN	NN	_	9	compound	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	LIP	lip	NN	NN	_	2	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	12	conj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	activated	activate	VBN	VBN	_	19	amod	_	_
18	U1	u1	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	demonstrating	demonstrate	VBG	VBG	_	10	advcl	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	C/EBP	c/ebp	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	required	require	VBN	VBN	_	21	ccomp	_	_
27	for	for	IN	IN	_	29	case	_	_
28	provirus	provirus	NN	NN	_	29	compound	_	_
29	induction	induction	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	U1	u1	NN	NN	_	2	compound	_	_
2	lines	line	NNS	NNS	_	7	nsubj	_	_
3	overexpressing	overexpress	VBG	VBG	_	2	acl	_	_
4	C/EBP	c/ebp	NN	NN	_	6	compound	_	_
5	activator	activator	NN	NN	_	6	compound	_	_
6	NF-IL-6	nf-il-6	NN	NN	_	3	dobj	_	_
7	produced	produce	VBD	VBD	_	0	root	_	_
8	more	more	JJR	JJR	_	7	dobj	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	mRNA	mrna	NN	NN	_	8	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	particles	particle	NNS	NNS	_	10	conj	_	_
14	following	follow	VBG	VBG	_	16	case	_	_
15	cellular	cellular	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	7	nmod	_	_
17	than	than	IN	IN	_	19	case	_	_
18	control	control	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	7	nmod	_	_
20	,	,	,	,	_	7	punct	_	_
21	demonstrating	demonstrate	VBG	VBG	_	7	advcl	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	C/EBP	c/ebp	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	26	nsubj	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	limiting	limit	VBG	VBG	_	21	ccomp	_	_
27	for	for	IN	IN	_	29	case	_	_
28	virus	virus	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
2	harboring	harboring	NN	NN	_	3	compound	_	_
3	mutations	mutation	NNS	NNS	_	9	nsubjpass	_	_
4	within	within	IN	IN	_	7	case	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	crippled	cripple	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	ability	ability	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	replicate	replicate	VB	VB	_	12	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	U937	u937	NN	NN	_	18	compound	_	_
17	promonocytic	promonocytic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	indicating	indicate	VBG	VBG	_	9	xcomp	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	these	these	DT	DT	_	23	det	_	_
23	sites	site	NNS	NNS	_	25	nsubjpass	_	_
24	are	be	VBP	VBP	_	25	auxpass	_	_
25	required	require	VBN	VBN	_	20	ccomp	_	_
26	for	for	IN	IN	_	27	case	_	_
27	replication	replication	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	C/EBP	c/ebp	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	3	dobj	_	_
6	as	as	IN	IN	_	7	case	_	_
7	regulators	regulator	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Reversal	reversal	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	leukaemia-associated	leukaemia-associated	JJ	JJ	_	10	amod	_	_
7	E2A-HLF	e2a-hlf	NN	NN	_	10	compound	_	_
8	chimaeric	chimaeric	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	E2A-HLF	e2a-hlf	NN	NN	_	10	compound	_	_
3	(	(	-LRB-	-LRB-	_	2	punct	_	_
4	for	for	IN	IN	_	7	case	_	_
5	hepatic	hepatic	JJ	JJ	_	7	amod	_	_
6	leukaemia	leukaemia	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	)	)	-RRB-	-RRB-	_	2	punct	_	_
9	fusion	fusion	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	22	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	formed	form	VBN	VBN	_	10	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	action	action	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	t(17;19)	t(17;19)	NN	NN	_	20	compound	_	_
18	(q22;p13)	(q22;p13)	NN	NN	_	20	compound	_	_
19	chromosomal	chromosomal	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	drives	drive	VBZ	VBZ	_	0	root	_	_
23	the	the	DT	DT	_	25	det	_	_
24	leukaemic	leukaemic	JJ	JJ	_	25	amod	_	_
25	transformation	transformation	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	early	early	JJ	JJ	_	29	amod	_	_
28	B-cell	b-cell	NN	NN	_	29	compound	_	_
29	precursors	precursor	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	22	punct	_	_
31	but	but	CC	CC	_	22	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	mechanism	mechanism	NN	NN	_	37	nsubj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	activity	activity	NN	NN	_	33	nmod	_	_
37	remains	remain	VBZ	VBZ	_	22	conj	_	_
38	unknown	unknown	JJ	JJ	_	37	xcomp	_	_
39	.	.	.	.	_	22	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	leukaemia	leukaemia	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	13	nsubj	_	_
8	carrying	carry	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	translocation	translocation	NN	NN	_	11	compound	_	_
11	t(17;19)	t(17;19)	NN	NN	_	8	dobj	_	_
12	rapidly	rapidly	RB	RB	_	13	advmod	_	_
13	died	die	VBD	VBD	_	3	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	programmed	program	VBN	VBN	_	13	advcl	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	express	express	VB	VB	_	17	xcomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	dominant-negative	dominant-negative	JJ	JJ	_	22	amod	_	_
22	suppressor	suppressor	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	fusion	fusion	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	E2A-HLF	e2a-hlf	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	13	punct	_	_
29	indicating	indicate	VBG	VBG	_	13	xcomp	_	_
30	that	that	IN	IN	_	35	mark	_	_
31	the	the	DT	DT	_	33	det	_	_
32	chimaeric	chimaeric	JJ	JJ	_	33	amod	_	_
33	oncoprotein	oncoprotein	NN	NN	_	35	nsubj	_	_
34	probably	probably	RB	RB	_	35	advmod	_	_
35	affects	affect	VBZ	VBZ	_	29	ccomp	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	survival	survival	NN	NN	_	35	dobj	_	_
38	rather	rather	RB	RB	_	37	cc	_	_
39	than	than	IN	IN	_	38	mwe	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	growth	growth	NN	NN	_	37	conj	_	_
42	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	when	when	WRB	WRB	_	4	advmod	_	_
4	introduced	introduce	VBN	VBN	_	15	advcl	_	_
5	into	into	IN	IN	_	8	case	_	_
6	murine	murine	JJ	JJ	_	8	amod	_	_
7	pro-B	pro-b	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	the	the	DT	DT	_	14	det	_	_
11	oncogenic	oncogenic	JJ	JJ	_	14	amod	_	_
12	E2A-HLF	e2a-hlf	NN	NN	_	14	compound	_	_
13	fusion	fusion	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	15	nsubj	_	_
15	reversed	reverse	VBD	VBD	_	0	root	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	interleukin-3-dependent	interleukin-3-dependent	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	p53-mediated	p53-mediated	JJ	JJ	_	17	conj	_	_
20	apoptosis	apoptosis	NN	NN	_	15	dobj	_	_
21	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	close	close	JJ	JJ	_	3	amod	_	_
3	homology	homology	NN	NN	_	29	nsubj	_	_
4	of	of	IN	IN	_	15	case	_	_
5	the	the	DT	DT	_	15	det	_	_
6	basic	basic	JJ	JJ	_	8	amod	_	_
7	region/leucine	region/leucine	NN	NN	_	8	compound	_	_
8	zipper	zipper	NN	NN	_	15	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	bZIP	bzip	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	dimerization	dimerization	NN	NN	_	12	conj	_	_
15	domain	domain	NN	NN	_	3	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HLF	hlf	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	that	that	DT	DT	_	3	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	CES-2	ces-2	NN	NN	_	25	compound	_	_
23	cell-death	cell-death	NN	NN	_	25	compound	_	_
24	specification	specification	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	Caenorhabditis	caenorhabditis	NN	NN	_	28	compound	_	_
28	elegans	elegan	NNS	NNS	_	25	nmod	_	_
29	suggests	suggest	VBZ	VBZ	_	0	root	_	_
30	a	a	DT	DT	_	31	det	_	_
31	model	model	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	leukaemogenesis	leukaemogenesis	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	which	which	WDT	WDT	_	37	nmod	_	_
36	E2A-HLF	e2a-hlf	NN	NN	_	37	nsubj	_	_
37	blocks	block	VBZ	VBZ	_	31	acl:relcl	_	_
38	an	a	DT	DT	_	40	det	_	_
39	early	early	JJ	JJ	_	40	amod	_	_
40	step	step	NN	NN	_	37	dobj	_	_
41	within	within	IN	IN	_	46	case	_	_
42	an	a	DT	DT	_	46	det	_	_
43	evolutionarily	evolutionarily	RB	RB	_	44	advmod	_	_
44	conserved	conserve	VBN	VBN	_	46	amod	_	_
45	cell-death	cell-death	NN	NN	_	46	compound	_	_
46	pathway	pathway	NN	NN	_	40	nmod	_	_
47	.	.	.	.	_	29	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-10	il-10	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-4	il-4	NN	NN	_	3	conj	_	_
6	on	on	IN	IN	_	9	case	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AP-1	ap-1	NN	NN	_	9	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	NF-IL6	nf-il6	NN	NN	_	11	conj	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	11	conj	_	_
17	)	)	-RRB-	-RRB-	_	11	punct	_	_
18	which	which	WDT	WDT	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	9	acl:relcl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	IL-6	il-6	NN	NN	_	23	compound	_	_
23	regulation	regulation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	10	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-10	il-10	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	10	punct	_	_
6	like	like	IN	IN	_	7	case	_	_
7	IL-4	il-4	NN	NN	_	10	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	known	know	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	inhibit	inhibit	VB	VB	_	10	xcomp	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	showed	show	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	IL-10	il-10	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-4	il-4	NN	NN	_	5	conj	_	_
8	inhibit	inhibit	VBP	VBP	_	2	ccomp	_	_
9	LPS-induced	lps-induced	JJ	JJ	_	14	amod	_	_
10	IL-6	il-6	NN	NN	_	14	compound	_	_
11	mRNA	mrna	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	protein	protein	NN	NN	_	11	conj	_	_
14	expression	expression	NN	NN	_	8	dobj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	inhibiting	inhibit	VBG	VBG	_	8	advcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	rate	rate	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-6	il-6	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	strong	strong	JJ	JJ	_	3	amod	_	_
3	inhibition	inhibition	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	IL-6	il-6	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	rate	rate	NN	NN	_	3	nmod	_	_
9	prompted	prompt	VBD	VBD	_	0	root	_	_
10	us	we	PRP	PRP	_	9	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	study	study	VB	VB	_	9	xcomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effect	effect	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-10	il-10	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-4	il-4	NN	NN	_	16	conj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	questioned	question	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	not	not	RB	RB	_	3	mwe	_	_
6	IL-10	il-10	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-4	il-4	NN	NN	_	6	conj	_	_
9	affected	affect	VBD	VBD	_	2	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	known	know	VBN	VBN	_	14	acl:relcl	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	involved	involve	VBN	VBN	_	17	xcomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	control	control	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	IL-6	il-6	NN	NN	_	28	compound	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	rate	rate	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	14	punct	_	_
30	namely	namely	RB	RB	_	14	advmod	_	_
31	activator	activator	NN	NN	_	32	compound	_	_
32	protein-1	protein-1	NN	NN	_	14	dep	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	AP-1	ap-1	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	32	punct	_	_
37	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
38	factor	factor	NN	NN	_	39	compound	_	_
39	IL-6	il-6	NN	NN	_	32	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	NF-IL6	nf-il6	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	32	punct	_	_
44	and	and	CC	CC	_	32	cc	_	_
45	nuclear	nuclear	JJ	JJ	_	48	amod	_	_
46	factor	factor	NN	NN	_	48	compound	_	_
47	kappa	kappa	NN	NN	_	48	compound	_	_
48	B	b	NN	NN	_	32	conj	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	NF-kappaB	nf-kappab	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	10	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EMSAs	emsa	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	15	mark	_	_
12	IL-10	il-10	NN	NN	_	15	nsubj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL-4	il-4	NN	NN	_	12	conj	_	_
15	inhibited	inhibit	VBD	VBD	_	10	ccomp	_	_
16	LPS-induced	lps-induced	JJ	JJ	_	19	amod	_	_
17	AP-1	ap-1	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	dobj	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibiting	inhibiting	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-4	il-4	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	9	cop	_	_
7	slightly	slightly	RB	RB	_	8	advmod	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	pronounced	pronounced	JJ	JJ	_	0	root	_	_
10	than	than	IN	IN	_	11	case	_	_
11	that	that	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-10	il-10	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Downregulation	downregulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	LPS-induced	lps-induced	JJ	JJ	_	4	amod	_	_
4	AP-1	ap-1	NN	NN	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	thus	thus	RB	RB	_	6	advmod	_	_
10	possibly	possibly	RB	RB	_	11	advmod	_	_
11	explained	explain	VBN	VBN	_	6	dep	_	_
12	,	,	,	,	_	6	punct	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	reduced	reduce	VBN	VBN	_	16	amod	_	_
16	expression	expression	NN	NN	_	6	nmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	level	level	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	two	two	CD	CD	_	24	nummod	_	_
23	major	major	JJ	JJ	_	24	amod	_	_
24	components	component	NNS	NNS	_	16	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	AP-1	ap-1	NN	NN	_	28	compound	_	_
28	complex	complex	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	namely	namely	RB	RB	_	24	advmod	_	_
31	c-fos	c-fos	NN	NN	_	24	dep	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	c-jun	c-jun	NN	NN	_	31	conj	_	_
34	as	as	IN	IN	_	35	mark	_	_
35	determined	determine	VBN	VBN	_	31	dep	_	_
36	by	by	IN	IN	_	38	case	_	_
37	Northern	northern	NN	NN	_	38	compound	_	_
38	experiments	experiment	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-IL6	nf-il6	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	8	auxpass	_	_
6	also	also	RB	RB	_	8	advmod	_	_
7	strongly	strongly	RB	RB	_	8	advmod	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-4	il-4	NN	NN	_	8	nmod	_	_
11	whereas	whereas	IN	IN	_	8	dep	_	_
12	IL-10	il-10	NN	NN	_	13	nsubj	_	_
13	showed	show	VBD	VBD	_	8	parataxis	_	_
14	no	no	DT	DT	_	15	neg	_	_
15	effect	effect	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	8	punct	_	_

1	NF-IL6	nf-il6	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affected	affect	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	IL-10	il-10	NN	NN	_	6	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	IL-4	il-4	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
13	that	that	IN	IN	_	15	mark	_	_
14	IL-4	il-4	NN	NN	_	15	nsubj	_	_
15	affects	affect	VBZ	VBZ	_	12	ccomp	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	preexisting	preexist	VBG	VBG	_	20	amod	_	_
20	NF-IL6	nf-il6	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Neither	neither	CC	CC	_	2	cc:preconj	_	_
2	IL-10	il-10	NN	NN	_	5	nsubj	_	_
3	nor	nor	CC	CC	_	2	cc	_	_
4	IL-4	il-4	NN	NN	_	2	conj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	LPS-induced	lps-induced	JJ	JJ	_	10	amod	_	_
7	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	5	dobj	_	_
11	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	agreement	agreement	NN	NN	_	5	dep	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	finding	finding	NN	NN	_	18	nmod	_	_
6	,	,	,	,	_	18	punct	_	_
7	Northern	northern	NN	NN	_	8	compound	_	_
8	experiments	experiment	NNS	NNS	_	18	nsubj	_	_
9	where	where	WRB	WRB	_	16	advmod	_	_
10	p65	p65	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	p105	p105	NN	NN	_	10	conj	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	determined	determine	VBN	VBN	_	8	acl:relcl	_	_
17	,	,	,	,	_	18	punct	_	_
18	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	32	mark	_	_
20	expression	expression	NN	NN	_	32	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	components	component	NNS	NNS	_	20	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	23	nmod	_	_
30	were	be	VBD	VBD	_	32	auxpass	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	affected	affect	VBN	VBN	_	18	ccomp	_	_
33	by	by	IN	IN	_	34	case	_	_
34	IL-10	il-10	NN	NN	_	32	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	IL-4	il-4	NN	NN	_	34	conj	_	_
37	.	.	.	.	_	18	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	neither	neither	CC	CC	_	4	cc:preconj	_	_
4	IL-10	il-10	NN	NN	_	7	nsubj	_	_
5	nor	nor	CC	CC	_	4	cc	_	_
6	IL-4	il-4	NN	NN	_	4	conj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	any	any	DT	DT	_	9	det	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	14	case	_	_
11	I-kappa	i-kappa	NN	NN	_	14	compound	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	9	nmod	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	determined	determine	VBN	VBN	_	7	advcl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	Northern	northern	NN	NN	_	19	compound	_	_
19	experiments	experiment	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	IL-10	il-10	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-4	il-4	NN	NN	_	3	conj	_	_
6	similarly	similarly	RB	RB	_	7	advmod	_	_
7	affect	affect	VBP	VBP	_	0	root	_	_
8	IL-6	il-6	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	for	for	IN	IN	_	4	case	_	_
4	IL-4	il-4	NN	NN	_	7	nmod	_	_
5	this	this	DT	DT	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	accompanied	accompany	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	reduction	reduction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	AP-1	ap-1	NN	NN	_	16	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-IL6	nf-il6	NN	NN	_	12	conj	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	10	nmod	_	_
17	whereas	whereas	IN	IN	_	20	mark	_	_
18	IL-10	il-10	NN	NN	_	20	nsubj	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	inhibited	inhibit	VBD	VBD	_	7	advcl	_	_
21	AP-1	ap-1	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	7	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecule	molecule	NN	NN	_	9	compound	_	_
9	induction	induction	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Induction	induction	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
4	adhesion	adhesion	NN	NN	_	5	compound	_	_
5	molecules	molecule	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cytokine	cytokine	NN	NN	_	1	nmod	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor-alpha	factor-alpha	NN	NN	_	8	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TNF	tnf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	occur	occur	VB	VB	_	0	root	_	_
17	independently	independently	RB	RB	_	16	advmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	protein	protein	NN	NN	_	21	compound	_	_
20	kinase	kinase	NN	NN	_	21	compound	_	_
21	C	c	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	activation	activation	NN	NN	_	35	nsubjpass	_	_
24	of	of	IN	IN	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	protein	protein	NN	NN	_	28	compound	_	_
27	tyrosine	tyrosine	NN	NN	_	28	compound	_	_
28	kinase	kinase	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PTK	ptk	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	has	have	VBZ	VBZ	_	35	aux	_	_
33	recently	recently	RB	RB	_	35	advmod	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	implicated	implicate	VBN	VBN	_	16	conj	_	_
36	in	in	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	upregulation	upregulation	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	vascular	vascular	JJ	JJ	_	43	amod	_	_
41	cell	cell	NN	NN	_	43	compound	_	_
42	adhesion	adhesion	NN	NN	_	43	compound	_	_
43	molecule	molecule	NN	NN	_	38	nmod	_	_
44	1	1	CD	CD	_	43	nummod	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	VCAM-1	vcam-1	NN	NN	_	43	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	by	by	IN	IN	_	49	case	_	_
49	interleukin-4	interleukin-4	NN	NN	_	38	nmod	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	IL-4	il-4	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	on	on	IN	IN	_	55	case	_	_
54	endothelial	endothelial	JJ	JJ	_	55	amod	_	_
55	cells	cell	NNS	NNS	_	49	nmod	_	_
56	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	PTK	ptk	NN	NN	_	6	compound	_	_
6	inhibitors	inhibitor	NNS	NNS	_	11	nsubj	_	_
7	herbimycin	herbimycin	NN	NN	_	8	compound	_	_
8	A	a	NN	NN	_	6	dep	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	genistein	genistein	NN	NN	_	8	conj	_	_
11	suppress	suppress	VBP	VBP	_	2	ccomp	_	_
12	induction	induction	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	endothelial	endothelial	JJ	JJ	_	15	amod	_	_
15	VCAM-1	vcam-1	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	E-selectin	e-selectin	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	as	as	RB	RB	_	12	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	subsequent	subsequent	JJ	JJ	_	25	amod	_	_
23	monocytic	monocytic	JJ	JJ	_	22	dep	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	adhesion	adhesion	NN	NN	_	12	conj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	stimulated	stimulate	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	31	case	_	_
31	TNF	tnf	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	specific	specific	JJ	JJ	_	7	amod	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	12	nsubjpass	_	_
8	following	follow	VBG	VBG	_	7	acl	_	_
9	PTK	ptk	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mobilization	mobilization	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
22	factor	factor	NN	NN	_	24	compound	_	_
23	kappa	kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	19	appos	_	_
25	,	,	,	,	_	15	punct	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	VCAM-1	vcam-1	NN	NN	_	28	compound	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	15	conj	_	_
30	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	have	have	VB	VB	_	0	root	_	_
4	implications	implication	NNS	NNS	_	3	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	pathophysiological	pathophysiological	JJ	JJ	_	7	amod	_	_
7	conditions	condition	NNS	NNS	_	4	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	involve	involve	VBP	VBP	_	7	acl:relcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	upregulation	upregulation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	molecules	molecule	NNS	NNS	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	e.g.	e.g.	FW	FW	_	17	dep	_	_
17	inflammation	inflammation	NN	NN	_	7	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	atherosclerosis	atherosclerosis	NN	NN	_	17	conj	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	transcription	transcription	NN	NN	_	6	compound	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	Stat1	stat1	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	cultures	culture	NNS	NNS	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	by	by	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	cyclic	cyclic	JJ	JJ	_	19	amod	_	_
17	AMP	amp	NN	NN	_	19	compound	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	pathway	pathway	NN	NN	_	1	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	results	result	VBZ	VBZ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	cascade	cascade	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
14	proliferation	proliferation	NN	NN	_	11	conj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	differentiation	differentiation	NN	NN	_	14	conj	_	_
17	into	into	IN	IN	_	19	case	_	_
18	effector	effector	NN	NN	_	19	compound	_	_
19	phenotypes	phenotype	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	belonging	belong	VBG	VBG	_	5	acl	_	_
7	to	to	TO	TO	_	18	case	_	_
8	the	the	DT	DT	_	18	det	_	_
9	signal	signal	NN	NN	_	10	compound	_	_
10	transducer	transducer	NN	NN	_	18	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	activator	activator	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	transcription	transcription	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	STAT	stat	NN	NN	_	10	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	family	family	NN	NN	_	6	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	analyzed	analyze	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	PHA-activated	pha-activated	JJ	JJ	_	24	amod	_	_
23	mononuclear	mononuclear	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	in	in	IN	IN	_	29	case	_	_
27	purified	purify	VBN	VBN	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	conj	_	_
30	activated	activate	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	35	case	_	_
32	cross-linking	cross-linking	JJ	JJ	_	35	amod	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	surface	surface	NN	NN	_	35	compound	_	_
35	CD3	cd3	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	20	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	delayed	delay	VBN	VBN	_	7	amod	_	_
7	induction	induction	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	STAT	stat	NN	NN	_	11	compound	_	_
10	DNA-binding	dna-binding	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	was	be	VBD	VBD	_	15	aux	_	_
15	sustained	sustained	JJ	JJ	_	7	acl:relcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	days	day	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	composed	compose	VBN	VBN	_	15	conj	_	_
22	predominantly	predominantly	RB	RB	_	21	advmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Stat1	stat1	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Stat3	stat3	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	15	punct	_	_
28	and	and	CC	CC	_	15	cc	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	blocked	block	VBN	VBN	_	15	conj	_	_
31	by	by	IN	IN	_	32	case	_	_
32	cycloheximide	cycloheximide	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	actinomycin	actinomycin	NN	NN	_	35	compound	_	_
35	D	d	NN	NN	_	32	conj	_	_
36	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	8	amod	_	_
2	Stat1	stat1	NN	NN	_	8	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Stat3	stat3	NN	NN	_	2	conj	_	_
5	mRNA	mrna	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	protein	protein	NN	NN	_	5	conj	_	_
8	levels	level	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	respectively	respectively	RB	RB	_	16	advmod	_	_
13	4	4	CD	CD	_	16	nummod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	24	24	CD	CD	_	13	conj	_	_
16	h	h	NN	NN	_	10	nmod	_	_
17	after	after	IN	IN	_	16	case	_	_
18	activation	activation	NN	NN	_	16	dep	_	_
19	.	.	.	.	_	10	punct	_	_

1	Stimulation	stimulation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	cAMP	camp	NN	NN	_	7	compound	_	_
5	signal	signal	NN	NN	_	7	compound	_	_
6	transduction	transduction	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	1	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	skews	skew	VBZ	VBZ	_	1	acl:relcl	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	toward	toward	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	pattern	pattern	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	1	punct	_	_
18	resulted	result	VBD	VBD	_	0	root	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	preferential	preferential	JJ	JJ	_	22	amod	_	_
22	suppression	suppression	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Stat1	stat1	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	cAMP	camp	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	induction	induction	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	expression	expression	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	IL-2	il-2	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	components	component	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	but	but	CC	CC	_	2	cc	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	inhibit	inhibit	VB	VB	_	2	conj	_	_
16	IL-4	il-4	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	alpha-chain	alpha-chain	NN	NN	_	21	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CD69	cd69	NN	NN	_	18	conj	_	_
21	expression	expression	NN	NN	_	15	dobj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	induction	induction	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	activator	activator	NN	NN	_	30	compound	_	_
27	protein	protein	NN	NN	_	30	compound	_	_
28	1	1	CD	CD	_	30	nummod	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	cAMP	camp	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	Stat1	stat1	NN	NN	_	3	dobj	_	_
5	at	at	IN	IN	_	8	case	_	_
6	several	several	JJ	JJ	_	8	amod	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	22	case	_	_
11	suppression	suppression	NN	NN	_	22	compound	_	_
12	of	of	IN	IN	_	14	case	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	down-regulation	down-regulation	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Stat1	stat1	NN	NN	_	16	nmod	_	_
19	protein	protein	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	mRNA	mrna	NN	NN	_	19	conj	_	_
22	levels	level	NNS	NNS	_	8	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT	stat	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	5	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	regulates	regulate	VBZ	VBZ	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	19	det	_	_
16	T	t	NN	NN	_	19	compound	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	phenotype	phenotype	NN	NN	_	14	dobj	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	distinct	distinct	JJ	JJ	_	14	conj	_	_
23	from	from	IN	IN	_	29	case	_	_
24	the	the	DT	DT	_	29	det	_	_
25	cytokine-activated	cytokine-activated	JJ	JJ	_	29	amod	_	_
26	Janus	janus	NN	NN	_	29	compound	_	_
27	kinase-STAT	kinase-stat	NN	NN	_	29	compound	_	_
28	signaling	signaling	NN	NN	_	29	compound	_	_
29	pathway	pathway	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	oriP	orip	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	essential	essential	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	8	case	_	_
5	EBNA	ebna	NN	NN	_	8	compound	_	_
6	gene	gene	NN	NN	_	8	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
11	virus-immortalized	virus-immortalized	JJ	JJ	_	14	amod	_	_
12	lymphoblastoid	lymphoblastoid	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	During	during	IN	IN	_	5	case	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	latent	latent	JJ	JJ	_	5	amod	_	_
5	infection	infection	NN	NN	_	20	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	5	advmod	_	_
11	,	,	,	,	_	20	punct	_	_
12	six	six	CD	CD	_	15	nummod	_	_
13	viral	viral	JJ	JJ	_	15	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	antigens	antigen	NNS	NNS	_	20	nsubjpass	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	EBNAs	ebnas	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	expressed	express	VBN	VBN	_	0	root	_	_
21	from	from	IN	IN	_	22	case	_	_
22	one	one	CD	CD	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	two	two	CD	CD	_	25	nummod	_	_
25	promoters	promoter	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	Cp	cp	NN	NN	_	25	appos	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	Wp	wp	NN	NN	_	27	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	whose	whose	WP$	WP$	_	32	nmod:poss	_	_
32	activities	activity	NNS	NNS	_	35	nsubj	_	_
33	are	be	VBP	VBP	_	35	cop	_	_
34	mutually	mutually	RB	RB	_	35	advmod	_	_
35	exclusive	exclusive	JJ	JJ	_	25	acl:relcl	_	_
36	.	.	.	.	_	20	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	infection	infection	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	Wp	wp	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	initially	initially	RB	RB	_	7	advmod	_	_
7	active	active	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	followed	follow	VBN	VBN	_	7	dep	_	_
10	by	by	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	switch	switch	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	Cp	cp	NN	NN	_	12	nmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	duration	duration	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	latency	latency	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	region	region	NN	NN	_	11	nsubjpass	_	_
7	upstream	upstream	JJ	JJ	_	6	advmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Cp	cp	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cis	cis	NN	NN	_	17	compound	_	_
17	elements	element	NNS	NNS	_	14	nmod	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	regulating	regulate	VBG	VBG	_	18	advcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activities	activity	NNS	NNS	_	20	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	EBNA	ebna	NN	NN	_	27	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	promoters	promoter	NNS	NNS	_	22	nmod	_	_
28	in	in	IN	IN	_	35	case	_	_
29	established	established	JJ	JJ	_	35	amod	_	_
30	in	in	FW	FW	_	35	amod	_	_
31	vitro	vitro	FW	FW	_	30	dep	_	_
32	immortalized	immortalize	VBN	VBN	_	35	amod	_	_
33	lymphoblastoid	lymphoblastoid	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	14	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	LCLs	lcl	NNS	NNS	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	11	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	oriP	orip	NN	NN	_	16	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	origin	origin	NN	NN	_	5	appos	_	_
9	for	for	IN	IN	_	11	case	_	_
10	episomal	episomal	JJ	JJ	_	11	amod	_	_
11	maintenance	maintenance	NN	NN	_	8	nmod	_	_
12	during	during	IN	IN	_	13	case	_	_
13	latency	latency	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	essential	essential	JJ	JJ	_	3	ccomp	_	_
17	for	for	IN	IN	_	20	case	_	_
18	efficient	efficient	JJ	JJ	_	20	amod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	initiation	initiation	NN	NN	_	16	nmod	_	_
21	from	from	IN	IN	_	23	case	_	_
22	either	either	CC	CC	_	23	cc:preconj	_	_
23	Cp	cp	NN	NN	_	20	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	Wp	wp	NN	NN	_	23	conj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	LCLs	lcls	NN	NN	_	20	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	as	as	RB	RB	_	27	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	in	in	IN	IN	_	38	case	_	_
33	some	some	DT	DT	_	38	det	_	_
34	Burkitt	burkitt	NN	NN	_	38	nmod:poss	_	_
35	's	's	POS	POS	_	34	case	_	_
36	lymphoma	lymphoma	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	27	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	Deletion	deletion	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	EBNA2-dependent	ebna2-dependent	JJ	JJ	_	5	amod	_	_
5	enhancer	enhancer	NN	NN	_	1	nmod	_	_
6	located	located	JJ	JJ	_	5	amod	_	_
7	upstream	upstream	RB	RB	_	6	advmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Cp	cp	NN	NN	_	7	nmod	_	_
10	resulted	result	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	17	case	_	_
12	a	a	DT	DT	_	17	det	_	_
13	ca.	ca.	FW	FW	_	14	dep	_	_
14	two-	two-	CD	CD	_	17	nummod	_	_
15	to	to	TO	TO	_	14	dep	_	_
16	fivefold	fivefold	JJ	JJ	_	14	advmod	_	_
17	reduction	reduction	NN	NN	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	Cp	cp	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	LCLs	lcl	NNS	NNS	_	20	nmod	_	_
24	assayed	assay	VBN	VBN	_	23	acl	_	_
25	.	.	.	.	_	10	punct	_	_

1	More	more	RBR	RBR	_	2	advmod	_	_
2	extensive	extensive	JJ	JJ	_	3	amod	_	_
3	deletion	deletion	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	sequences	sequence	NNS	NNS	_	3	nmod	_	_
6	upstream	upstream	JJ	JJ	_	5	advmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Cp	cp	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	including	include	VBG	VBG	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	EBNA2-dependent	ebna2-dependent	JJ	JJ	_	13	amod	_	_
13	enhancer	enhancer	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	nearly	nearly	RB	RB	_	18	advmod	_	_
18	complete	complete	JJ	JJ	_	19	amod	_	_
19	loss	loss	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	Cp	cp	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	loss	loss	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	activity	activity	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	correlate	correlate	VB	VB	_	6	xcomp	_	_
9	with	with	IN	IN	_	10	case	_	_
10	deletion	deletion	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	CCAAT	ccaat	NN	NN	_	14	compound	_	_
14	boxes	box	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	a	a	DT	DT	_	19	det	_	_
17	proximal	proximal	JJ	JJ	_	19	amod	_	_
18	CCAAT	ccaat	NN	NN	_	19	compound	_	_
19	box	box	NN	NN	_	14	appos	_	_
20	located	located	JJ	JJ	_	19	amod	_	_
21	at	at	IN	IN	_	22	case	_	_
22	bp	bp	NN	NN	_	20	nmod	_	_
23	-61	-61	CD	CD	_	22	dep	_	_
24	to	to	TO	TO	_	23	dep	_	_
25	-65	-65	CD	CD	_	23	dep	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	a	a	DT	DT	_	30	det	_	_
28	distal	distal	JJ	JJ	_	30	amod	_	_
29	CCAAT	ccaat	NN	NN	_	30	compound	_	_
30	box	box	NN	NN	_	19	conj	_	_
31	located	located	JJ	JJ	_	30	amod	_	_
32	at	at	IN	IN	_	33	case	_	_
33	bp	bp	NN	NN	_	31	dep	_	_
34	-253	-253	CD	CD	_	33	dep	_	_
35	to	to	TO	TO	_	34	dep	_	_
36	-257	-257	CD	CD	_	34	dep	_	_
37	,	,	,	,	_	33	punct	_	_
38	upstream	upstream	RB	RB	_	33	dep	_	_
39	of	of	IN	IN	_	40	case	_	_
40	Cp	cp	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	cis	cis	NN	NN	_	6	compound	_	_
6	elements	element	NNS	NNS	_	2	nmod	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	Cp	cp	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	13	nsubj	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	highly	highly	RB	RB	_	13	advmod	_	_
13	dependent	dependent	JJ	JJ	_	7	ccomp	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	properly	properly	RB	RB	_	20	advmod	_	_
20	positioned	position	VBN	VBN	_	22	amod	_	_
21	CCAAT	ccaat	NN	NN	_	22	compound	_	_
22	box	box	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	dependence	dependence	NN	NN	_	13	nmod	_	_
27	on	on	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	distal	distal	JJ	JJ	_	31	amod	_	_
30	CCAAT	ccaat	NN	NN	_	31	compound	_	_
31	box	box	NN	NN	_	26	nmod	_	_
32	apparent	apparent	JJ	JJ	_	31	amod	_	_
33	only	only	RB	RB	_	34	advmod	_	_
34	when	when	WRB	WRB	_	40	advmod	_	_
35	the	the	DT	DT	_	38	det	_	_
36	proximal	proximal	JJ	JJ	_	38	amod	_	_
37	CCAAT	ccaat	NN	NN	_	38	compound	_	_
38	box	box	NN	NN	_	40	nsubjpass	_	_
39	was	be	VBD	VBD	_	40	auxpass	_	_
40	deleted	delete	VBN	VBN	_	32	ccomp	_	_
41	or	or	CC	CC	_	40	cc	_	_
42	mutated	mutate	VBN	VBN	_	40	conj	_	_
43	.	.	.	.	_	7	punct	_	_

1	Deletion	deletion	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
5	response	response	NN	NN	_	6	compound	_	_
6	elements	element	NNS	NNS	_	1	nmod	_	_
7	located	located	JJ	JJ	_	6	amod	_	_
8	at	at	IN	IN	_	12	case	_	_
9	ca.	ca.	FW	FW	_	10	compound	_	_
10	bp	bp	NN	NN	_	12	nmod:npmod	_	_
11	-850	-850	CD	CD	_	10	nummod	_	_
12	upstream	upstream	RB	RB	_	7	advcl	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Cp	cp	NN	NN	_	12	nmod	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	result	result	VB	VB	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	significant	significant	JJ	JJ	_	21	amod	_	_
21	loss	loss	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	activity	activity	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	general	general	JJ	JJ	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	deletions	deletion	NNS	NNS	_	9	nsubj	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	diminished	diminish	VBD	VBD	_	4	acl:relcl	_	_
7	Cp	cp	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	induction	induction	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Wp	wp	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	consistent	consistent	JJ	JJ	_	9	xcomp	_	_
17	with	with	IN	IN	_	18	case	_	_
18	suppression	suppression	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	Wp	wp	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	18	nmod	_	_
22	by	by	IN	IN	_	24	case	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	interference	interference	NN	NN	_	18	nmod	_	_
25	from	from	IN	IN	_	26	case	_	_
26	Cp	cp	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	oriP	orip	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	8	det	_	_
7	EBNA2-dependent	ebna2-dependent	JJ	JJ	_	8	amod	_	_
8	enhancer	enhancer	NN	NN	_	4	conj	_	_
9	as	as	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	major	major	JJ	JJ	_	14	amod	_	_
12	positive	positive	JJ	JJ	_	14	amod	_	_
13	cis	cis	NN	NN	_	14	compound	_	_
14	elements	element	NNS	NNS	_	2	nmod	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	regulating	regulate	VBG	VBG	_	15	advcl	_	_
18	Cp	cp	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	LCL	lcl	NN	NN	_	19	nmod	_	_
22	suggests	suggest	VBZ	VBZ	_	0	root	_	_
23	that	that	IN	IN	_	29	mark	_	_
24	EBNA	ebna	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	29	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	largely	largely	RB	RB	_	29	advmod	_	_
29	autoregulated	autoregulate	VBN	VBN	_	22	ccomp	_	_
30	by	by	IN	IN	_	31	case	_	_
31	EBNA	ebna	NN	NN	_	29	nmod	_	_
32	1	1	CD	CD	_	31	nummod	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	EBNA	ebna	NN	NN	_	31	conj	_	_
35	2	2	CD	CD	_	34	nummod	_	_
36	.	.	.	.	_	22	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	modes	mode	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	basic	basic	JJ	JJ	_	6	amod	_	_
5	helix-loop-helix	helix-loop-helix	JJ	JJ	_	6	amod	_	_
6	protein-mediated	protein-mediated	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	murine	murine	JJ	JJ	_	12	amod	_	_
10	leukemia	leukemia	NN	NN	_	12	compound	_	_
11	virus	virus	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	lymphoid	lymphoid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcriptionally	transcriptionally	RB	RB	_	3	advmod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	regions	region	NNS	NNS	_	17	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	lymphomagenic	lymphomagenic	JJ	JJ	_	8	amod	_	_
8	Akv	akv	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	SL3-3	sl3-3	NN	NN	_	8	conj	_	_
11	murine	murine	JJ	JJ	_	13	amod	_	_
12	leukemia	leukemia	NN	NN	_	13	compound	_	_
13	retroviruses	retrovirus	NNS	NNS	_	8	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MLVs	mlv	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	contain	contain	VBP	VBP	_	0	root	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	types	type	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	E-box	e-box	NN	NN	_	23	compound	_	_
22	consensus	consensus	NN	NN	_	23	compound	_	_
23	motifs	motif	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	19	punct	_	_
25	CAGATG	cagatg	NN	NN	_	19	appos	_	_
26	.	.	.	.	_	17	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	type	type	NN	NN	_	7	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	EA/S	ea/s	NN	NN	_	2	appos	_	_
5	,	,	,	,	_	2	punct	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	located	located	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	upstream	upstream	JJ	JJ	_	12	amod	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	other	other	JJ	JJ	_	21	nsubj	_	_
17	,	,	,	,	_	16	punct	_	_
18	E(gre)	e(gre)	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	located	located	JJ	JJ	_	7	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	tandem	tandem	JJ	JJ	_	25	amod	_	_
25	repeat	repeat	NN	NN	_	21	nmod	_	_
26	with	with	IN	IN	_	28	case	_	_
27	enhancer	enhancer	NN	NN	_	28	compound	_	_
28	properties	property	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	requirements	requirement	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	individual	individual	JJ	JJ	_	9	amod	_	_
9	E-boxes	e-box	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	MLV	mlv	NN	NN	_	13	compound	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	5	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	11	nmod	_	_
5	only	only	RB	RB	_	4	advmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	E(gre)-binding	e(gre)-binding	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	complexes	complex	NNS	NNS	_	11	nsubj	_	_
11	included	include	VBD	VBD	_	0	root	_	_
12	ALF1	alf1	NN	NN	_	19	compound	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	HEB	heb	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	E2A	e2a	NN	NN	_	12	conj	_	_
17	basic	basic	JJ	JJ	_	19	amod	_	_
18	helix-loop-helix	helix-loop-helix	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	11	dobj	_	_
20	.	.	.	.	_	11	punct	_	_

1	Ectopic	ectopic	JJ	JJ	_	5	amod	_	_
2	ALF1	alf1	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	E2A	e2a	NN	NN	_	2	conj	_	_
5	proteins	protein	NNS	NNS	_	6	nsubj	_	_
6	required	require	VBD	VBD	_	0	root	_	_
7	intact	intact	JJ	JJ	_	9	amod	_	_
8	E(gre)	e(gre)	NN	NN	_	9	compound	_	_
9	motifs	motif	NNS	NNS	_	6	dobj	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	mediating	mediate	VBG	VBG	_	6	advcl	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	6	punct	_	_

1	ALF1	ALF1	NNP	NNP	_	2	nsubj	_	_
2	transactivated	transactivate	VBD	VBD	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Akv	akv	NN	NN	_	6	compound	_	_
6	MLV	mlv	NN	NN	_	3	nmod	_	_
7	through	through	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	E(gre)	e(gre)	NN	NN	_	11	compound	_	_
11	motifs	motif	NNS	NNS	_	2	nmod	_	_
12	equally	equally	RB	RB	_	2	advmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	whereas	whereas	IN	IN	_	2	dep	_	_
15	E2A	e2a	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	17	nsubj	_	_
17	required	require	VBD	VBD	_	2	parataxis	_	_
18	the	the	DT	DT	_	21	det	_	_
19	promoter-proximal	promoter-proximal	JJ	JJ	_	21	amod	_	_
20	E(gre)	e(gre)	NN	NN	_	21	compound	_	_
21	motif	motif	NN	NN	_	17	dobj	_	_
22	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	T-	t-	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	B-cell	b-cell	NN	NN	_	2	conj	_	_
5	lines	line	NNS	NNS	_	13	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	E(gre)	e(gre)	NN	NN	_	9	compound	_	_
9	motifs	motif	NNS	NNS	_	13	nsubj	_	_
10	were	be	VBD	VBD	_	13	cop	_	_
11	of	of	IN	IN	_	13	case	_	_
12	major	major	JJ	JJ	_	13	amod	_	_
13	importance	importance	NN	NN	_	0	root	_	_
14	for	for	IN	IN	_	18	case	_	_
15	Akv	akv	NN	NN	_	18	compound	_	_
16	MLV	mlv	NN	NN	_	18	compound	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	while	while	IN	IN	_	24	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	EA/S	ea/s	NN	NN	_	23	compound	_	_
23	motif	motif	NN	NN	_	24	nsubj	_	_
24	had	have	VBD	VBD	_	13	advcl	_	_
25	some	some	DT	DT	_	26	det	_	_
26	effect	effect	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	neither	neither	CC	CC	_	5	cc:preconj	_	_
5	E(gre)	e(gre)	NN	NN	_	8	compound	_	_
6	nor	nor	CC	CC	_	5	cc	_	_
7	EA/S	ea/s	NN	NN	_	5	conj	_	_
8	motifs	motif	NNS	NNS	_	9	nsubj	_	_
9	contributed	contribute	VBD	VBD	_	0	root	_	_
10	pronouncedly	pronouncedly	RB	RB	_	9	advmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	Akv	akv	NN	NN	_	14	compound	_	_
13	MLV	mlv	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	NIH	nih	NN	NN	_	18	compound	_	_
17	3T3	3t3	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	lacking	lack	VBG	VBG	_	18	acl	_	_
20	DNA-binding	dna-binding	JJ	JJ	_	26	amod	_	_
21	ALF1	alf1	NN	NN	_	26	compound	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	HEB	heb	NN	NN	_	21	conj	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	E2A	e2a	NN	NN	_	21	conj	_	_
26	proteins	protein	NNS	NNS	_	19	dobj	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Id1	id1	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	repress	repress	VB	VB	_	5	xcomp	_	_
8	ALF1	alf1	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	12	advmod	_	_
12	and	and	CC	CC	_	7	advmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	12	advmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	ectopic	ectopic	JJ	JJ	_	4	amod	_	_
4	Id1	id1	NN	NN	_	5	nsubj	_	_
5	repressed	repress	VBD	VBD	_	0	root	_	_
6	E(gre)-directed	e(gre)-directed	JJ	JJ	_	11	amod	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	6	cc	_	_
9	EA/S-directed	ea/s-directed	JJ	JJ	_	6	conj	_	_
10	MLV	mlv	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	5	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	lymphoid	lymphoid	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	E(gre)	e(gre)	NN	NN	_	5	compound	_	_
5	motifs	motif	NNS	NNS	_	13	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	interacting	interact	VBG	VBG	_	10	amod	_	_
8	basic	basic	JJ	JJ	_	10	amod	_	_
9	helix-loop-helix	helix-loop-helix	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	5	conj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	determinants	determinant	NNS	NNS	_	0	root	_	_
14	for	for	IN	IN	_	17	case	_	_
15	MLV	mlv	NN	NN	_	17	compound	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	lymphocytic	lymphocytic	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	human	human	JJ	JJ	_	10	amod	_	_
3	T-cell	t-cell	NN	NN	_	10	compound	_	_
4	leukemia	leukemia	NN	NN	_	10	compound	_	_
5	virus	virus	NN	NN	_	10	compound	_	_
6	type	type	NN	NN	_	10	compound	_	_
7	1	1	CD	CD	_	10	nummod	_	_
8	posttranscriptional	posttranscriptional	JJ	JJ	_	10	amod	_	_
9	trans-activator	trans-activator	NN	NN	_	10	compound	_	_
10	Rex	rex	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	15	det	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	export	export	NN	NN	_	15	compound	_	_
15	signal	signal	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Rex	rex	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	T-cell	t-cell	NN	NN	_	9	compound	_	_
7	leukemia	leukemia	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	3	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	export	export	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	unspliced	unspliced	JJ	JJ	_	20	amod	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	mRNA	mrna	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	,	,	,	,	_	16	punct	_	_
23	therefore	therefore	RB	RB	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	for	for	IN	IN	_	27	case	_	_
26	virus	virus	NN	NN	_	27	compound	_	_
27	replication	replication	NN	NN	_	16	conj	_	_
28	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	manuscript	manuscript	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	Rex	rex	NN	NN	_	9	nsubj	_	_
9	shuttles	shuttle	VBZ	VBZ	_	6	ccomp	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	nucleus	nucleus	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cytoplasm	cytoplasm	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	21	nsubj	_	_
21	constitutes	constitute	VBZ	VBZ	_	9	conj	_	_
22	a	a	DT	DT	_	25	det	_	_
23	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
24	export	export	NN	NN	_	25	compound	_	_
25	signal	signal	NN	NN	_	21	dobj	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	specifies	specify	VBZ	VBZ	_	25	acl:relcl	_	_
28	efficient	efficient	JJ	JJ	_	29	amod	_	_
29	transport	transport	NN	NN	_	27	dobj	_	_
30	to	to	TO	TO	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	cytoplasm	cytoplasm	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	model	model	NN	NN	_	4	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	Rex-mediated	rex-mediated	JJ	JJ	_	10	amod	_	_
10	trans-activation	trans-activation	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	17	nmod	_	_
13	Rex-viral	rex-viral	JJ	JJ	_	15	amod	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	complexes	complex	NNS	NNS	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	targeted	target	VBN	VBN	_	7	acl:relcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	export	export	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	direct	direct	JJ	JJ	_	24	amod	_	_
24	action	action	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	activation	activation	NN	NN	_	28	compound	_	_
28	domain	domain	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Multiple	multiple	JJ	JJ	_	4	amod	_	_
2	p21ras	p21ras	NN	NN	_	4	compound	_	_
3	effector	effector	NN	NN	_	4	compound	_	_
4	pathways	pathway	NNS	NNS	_	5	nsubj	_	_
5	regulate	regulate	VBP	VBP	_	0	root	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	17	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	Nuclear	nuclear	JJ	JJ	_	10	amod	_	_
6	Factor	factor	NN	NN	_	10	compound	_	_
7	of	of	IN	IN	_	10	amod	_	_
8	Activated	activate	VBN	VBN	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	appos	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	NFAT	nfat	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	major	major	JJ	JJ	_	17	amod	_	_
17	target	target	NN	NN	_	0	root	_	_
18	for	for	IN	IN	_	23	case	_	_
19	p21ras	p21ras	NN	NN	_	23	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	calcium	calcium	NN	NN	_	19	conj	_	_
22	signalling	signalling	NN	NN	_	23	compound	_	_
23	pathways	pathway	NNS	NNS	_	17	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IL-2	il-2	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	induced	induce	VBN	VBN	_	17	conj	_	_
31	by	by	IN	IN	_	33	case	_	_
32	p21ras	p21ras	NN	NN	_	33	compound	_	_
33	signals	signal	NNS	NNS	_	30	nmod	_	_
34	acting	act	VBG	VBG	_	33	acl	_	_
35	in	in	IN	IN	_	36	case	_	_
36	synergy	synergy	NN	NN	_	34	nmod	_	_
37	with	with	IN	IN	_	39	case	_	_
38	calcium/calcineurin	calcium/calcineurin	NN	NN	_	39	compound	_	_
39	signals	signal	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	17	punct	_	_

1	One	one	CD	CD	_	4	nummod	_	_
2	p21ras	p21ras	NN	NN	_	4	compound	_	_
3	effector	effector	NN	NN	_	4	compound	_	_
4	pathway	pathway	NN	NN	_	5	nsubj	_	_
5	involves	involve	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	MAP	map	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	ERK-2	erk-2	NN	NN	_	5	dobj	_	_
10	,	,	,	,	_	5	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	examined	examine	VBN	VBN	_	5	conj	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	NFAT	nfat	NN	NN	_	19	compound	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	dominant	dominant	JJ	JJ	_	5	amod	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	MAPKK-1	mapkk-1	NN	NN	_	1	nmod	_	_
6	prevents	prevent	VBZ	VBZ	_	0	root	_	_
7	NFAT	nfat	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	6	dobj	_	_
9	.	.	.	.	_	6	punct	_	_

1	Constitutively	constitutively	RB	RB	_	2	advmod	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	MAPKK-1	mapkk-1	NN	NN	_	5	nsubj	_	_
4	fully	fully	RB	RB	_	5	advmod	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	ERK-2	erk-2	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	Elk-1	elk-1	NN	NN	_	6	conj	_	_
12	,	,	,	,	_	5	punct	_	_
13	but	but	CC	CC	_	5	cc	_	_
14	does	do	VBZ	VBZ	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	substitute	substitute	VB	VB	_	5	conj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	p21ras	p21ras	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	synergize	synergize	VBP	VBP	_	16	conj	_	_
22	with	with	IN	IN	_	24	case	_	_
23	calcium/calcineurin	calcium/calcineurin	NN	NN	_	24	compound	_	_
24	signals	signal	NNS	NNS	_	21	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	induce	induce	VB	VB	_	21	xcomp	_	_
27	NFAT	nfat	NN	NN	_	26	dobj	_	_
28	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	dominant	dominant	JJ	JJ	_	5	amod	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	N17Rac	n17rac	NN	NN	_	1	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	prevents	prevent	VBZ	VBZ	_	0	root	_	_
8	TCR	tcr	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	p21ras	p21ras	NN	NN	_	8	conj	_	_
11	activation	activation	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NFAT	nfat	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	but	but	CC	CC	_	7	cc	_	_
16	without	without	IN	IN	_	17	mark	_	_
17	interfering	interfere	VBG	VBG	_	7	conj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	ERK-2	erk-2	NN	NN	_	21	compound	_	_
21	pathway	pathway	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NFAT	nfat	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	complex	complex	NN	NN	_	10	nmod	_	_
14	comprising	comprise	VBG	VBG	_	13	acl	_	_
15	a	a	DT	DT	_	16	det	_	_
16	member	member	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	NFAT	nfat	NN	NN	_	20	compound	_	_
20	group	group	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	AP-1	ap-1	NN	NN	_	24	compound	_	_
23	family	family	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	16	conj	_	_
25	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AP-1	ap-1	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	p21ras	p21ras	NN	NN	_	2	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	Rac-1	rac-1	NN	NN	_	10	compound	_	_
10	function	function	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	8	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	Rac-1	rac-1	NN	NN	_	4	nsubj	_	_
3	could	could	MD	MD	_	4	aux	_	_
4	mimic	mimic	VB	VB	_	0	root	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	p21ras	p21ras	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	induce	induce	VB	VB	_	4	dep	_	_
9	AP-1	ap-1	NN	NN	_	8	dobj	_	_
10	but	but	CC	CC	_	8	cc	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	8	conj	_	_
14	NFAT	nfat	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	combination	combination	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	MAPKK-1	mapkk-1	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Rac-1	rac-1	NN	NN	_	7	conj	_	_
10	could	could	MD	MD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	substitute	substitute	VB	VB	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	activated	activate	VBN	VBN	_	15	amod	_	_
15	p21ras	p21ras	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	synergize	synergize	VB	VB	_	12	conj	_	_
18	with	with	IN	IN	_	20	case	_	_
19	calcium	calcium	NN	NN	_	20	compound	_	_
20	signals	signal	NNS	NNS	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	induce	induce	VB	VB	_	17	xcomp	_	_
23	NFAT	nfat	NN	NN	_	22	dobj	_	_
24	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	p21ras	p21ras	NN	NN	_	4	compound	_	_
4	regulation	regulation	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NFAT	nfat	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	requires	require	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	effector	effector	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	12	nmod	_	_
17	including	include	VBG	VBG	_	18	case	_	_
18	those	those	DT	DT	_	16	nmod	_	_
19	regulated	regulate	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	MAPKK-1/ERK-2	mapkk-1/erk-2	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Rac-1	rac-1	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	Protein-tyrosine	protein-tyrosine	JJ	JJ	_	3	amod	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	lipopolysaccharide	lipopolysaccharide	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	interleukin	interleukin	NN	NN	_	11	compound	_	_
11	1beta	1beta	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	NFkappaB	nfkappab	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	8	cc	_	_
18	NFkappaB	nfkappab	NN	NN	_	20	compound	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	8	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	interleukin	interleukin	NN	NN	_	8	compound	_	_
6	1beta	1beta	NN	NN	_	8	compound	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	15	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	steady	steady	JJ	JJ	_	13	amod	_	_
11	state	state	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	8	conj	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	increased	increase	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	response	response	NN	NN	_	19	dep	_	_
18	to	to	TO	TO	_	19	case	_	_
19	lipopolysaccharide	lipopolysaccharide	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	predominantly	predominantly	RB	RB	_	24	advmod	_	_
22	as	as	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	result	result	NN	NN	_	15	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	increased	increase	VBN	VBN	_	27	amod	_	_
27	transcription	transcription	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	interleukin	interleukin	NN	NN	_	32	compound	_	_
31	1beta	1beta	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	Expression	expression	NN	NN	_	21	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	interleukin	interleukin	NN	NN	_	4	compound	_	_
4	1beta	1beta	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	cytokines	cytokine	NNS	NNS	_	4	conj	_	_
8	,	,	,	,	_	7	punct	_	_
9	such	such	JJ	JJ	_	11	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	interleukin	interleukin	NN	NN	_	7	nmod	_	_
12	6	6	CD	CD	_	11	nummod	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	tumor	tumor	NN	NN	_	17	compound	_	_
15	necrosis	necrosis	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	has	have	VBZ	VBZ	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	shown	show	VBN	VBN	_	0	root	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	dependent	dependent	JJ	JJ	_	21	xcomp	_	_
25	on	on	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	NFkappaB	nfkappab	NN	NN	_	31	appos	_	_
34	.	.	.	.	_	21	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	20	advcl	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	10	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	required	require	VBN	VBN	_	5	ccomp	_	_
14	for	for	IN	IN	_	17	case	_	_
15	NFkappaB	nfkappab	NN	NN	_	17	compound	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	translocation	translocation	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	sought	seek	VBD	VBD	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	determine	determine	VB	VB	_	20	xcomp	_	_
23	whether	whether	IN	IN	_	34	mark	_	_
24	NFkappaB	nfkappab	NN	NN	_	34	nsubj	_	_
25	translocated	translocate	VBN	VBN	_	24	acl	_	_
26	in	in	IN	IN	_	32	case	_	_
27	the	the	DT	DT	_	32	dep	_	_
28	absence	absence	NN	NN	_	32	dep	_	_
29	of	of	IN	IN	_	32	case	_	_
30	tyrosine	tyrosine	NN	NN	_	32	compound	_	_
31	kinase	kinase	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	25	nmod	_	_
33	was	be	VBD	VBD	_	34	cop	_	_
34	active	active	JJ	JJ	_	22	ccomp	_	_
35	in	in	IN	IN	_	36	mark	_	_
36	stimulating	stimulate	VBG	VBG	_	34	advcl	_	_
37	transcription	transcription	NN	NN	_	36	dobj	_	_
38	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	,	,	,	,	_	22	punct	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	pro-monocytic	pro-monocytic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	22	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	THP-1	thp-1	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	22	punct	_	_
15	the	the	DT	DT	_	17	det	_	_
16	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	22	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	interleukin	interleukin	NN	NN	_	20	compound	_	_
20	1beta	1beta	NN	NN	_	17	nmod	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
23	on	on	IN	IN	_	26	case	_	_
24	tyrosine	tyrosine	NN	NN	_	26	compound	_	_
25	kinase	kinase	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	kinases	kinase	NNS	NNS	_	5	nsubjpass	_	_
3	are	be	VBP	VBP	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	lipopolysaccharide-mediated	lipopolysaccharide-mediated	JJ	JJ	_	9	amod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	translocation	translocation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NFkappaB	nfkappab	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	in	in	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	dep	_	_
5	absence	absence	NN	NN	_	9	dep	_	_
6	of	of	IN	IN	_	9	case	_	_
7	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	19	nmod	_	_
10	,	,	,	,	_	19	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ability	ability	NN	NN	_	19	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NFkappaB	nfkappab	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	stimulate	stimulate	VB	VB	_	12	acl	_	_
17	transcription	transcription	NN	NN	_	16	dobj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	impaired	impaired	JJ	JJ	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	transcription	transcription	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	specific	specific	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	NFkappaB	nfkappab	NN	NN	_	6	nmod	_	_
9	;	;	:	:	_	6	punct	_	_
10	in	in	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	dep	_	_
12	absence	absence	NN	NN	_	16	dep	_	_
13	of	of	IN	IN	_	16	case	_	_
14	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	21	nmod	_	_
17	,	,	,	,	_	21	punct	_	_
18	AP-1-dependent	ap-1-dependent	JJ	JJ	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	enhanced	enhance	VBN	VBN	_	6	parataxis	_	_
22	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	,	,	,	,	_	22	punct	_	_
6	while	while	IN	IN	_	12	mark	_	_
7	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	mediators	mediator	NNS	NNS	_	8	nmod	_	_
12	requires	require	VBZ	VBZ	_	22	advcl	_	_
13	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	22	punct	_	_
17	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	22	nsubj	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	obligatory	obligatory	JJ	JJ	_	3	ccomp	_	_
23	for	for	IN	IN	_	26	case	_	_
24	lipopolysaccharide	lipopolysaccharide	NN	NN	_	26	compound	_	_
25	signal	signal	NN	NN	_	26	compound	_	_
26	transduction	transduction	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	5	nsubj	_	_
4	preferentially	preferentially	RB	RB	_	5	advmod	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	94-kD	94-kd	JJ	JJ	_	8	amod	_	_
8	STAT5A	stat5a	NN	NN	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	an	a	DT	DT	_	13	det	_	_
11	80-kD	80-kd	JJ	JJ	_	13	amod	_	_
12	STAT5A	stat5a	NN	NN	_	13	compound	_	_
13	isoform	isoform	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	immediate	immediate	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	activation	activation	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	28	case	_	_
15	the	the	DT	DT	_	28	det	_	_
16	Janus	janus	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	28	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	JAK2	jak2	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	STAT	stat	NN	NN	_	24	compound	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	17	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	STAT5	stat5	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	pathway	pathway	NN	NN	_	13	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	homologues	homologue	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	STAT5	stat5	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	STAT5A	stat5a	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	STAT5B	stat5b	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	as	as	RB	RB	_	5	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	lower	lower	JJR	JJR	_	20	amod	_	_
18	molecular	molecular	JJ	JJ	_	20	amod	_	_
19	weight	weight	NN	NN	_	20	compound	_	_
20	variants	variant	NNS	NNS	_	5	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	STAT5	stat5	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	31	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	STAT5	stat5	NN	NN	_	4	nmod	_	_
8	homologues	homologue	NNS	NNS	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	lower	lower	JJR	JJR	_	13	amod	_	_
11	molecular	molecular	JJ	JJ	_	13	amod	_	_
12	weight	weight	NN	NN	_	13	compound	_	_
13	variant	variant	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	monocytes	monocyte	NNS	NNS	_	16	conj	_	_
19	differentiated	differentiate	VBN	VBN	_	18	acl	_	_
20	into	into	IN	IN	_	21	case	_	_
21	macrophages	macrophage	NNS	NNS	_	19	nmod	_	_
22	by	by	IN	IN	_	23	case	_	_
23	culture	culture	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	macrophage-CSF	macrophage-csf	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	M-CSF	m-csf	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	31	punct	_	_
30	we	we	PRP	PRP	_	31	nsubj	_	_
31	measured	measure	VBD	VBD	_	0	root	_	_
32	the	the	DT	DT	_	36	det	_	_
33	GM-CSF	gm-csf	NN	NN	_	34	nmod:npmod	_	_
34	induced	induced	JJ	JJ	_	36	amod	_	_
35	tyrosine	tyrosine	NN	NN	_	36	compound	_	_
36	phosphorylation	phosphorylation	NN	NN	_	31	dobj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	STAT5A	stat5a	NN	NN	_	36	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	STAT5B	stat5b	NN	NN	_	38	conj	_	_
41	,	,	,	,	_	38	punct	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	any	any	DT	DT	_	48	det	_	_
44	lower	lower	JJR	JJR	_	48	amod	_	_
45	molecular	molecular	JJ	JJ	_	48	amod	_	_
46	weight	weight	NN	NN	_	48	compound	_	_
47	STAT5	stat5	NN	NN	_	48	compound	_	_
48	isoforms	isoform	NNS	NNS	_	38	conj	_	_
49	.	.	.	.	_	31	punct	_	_

1	Freshly	freshly	RB	RB	_	2	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	4	nsubj	_	_
4	expressed	express	VBD	VBD	_	0	root	_	_
5	94-kD	94-kd	JJ	JJ	_	6	amod	_	_
6	STAT5A	stat5a	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	92-kD	92-kd	JJ	JJ	_	9	amod	_	_
9	STAT5B	stat5b	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	an	a	DT	DT	_	15	det	_	_
13	80-kD	80-kd	JJ	JJ	_	15	amod	_	_
14	STAT5A	stat5a	NN	NN	_	15	compound	_	_
15	molecule	molecule	NN	NN	_	6	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	94-kD	94-kd	JJ	JJ	_	3	amod	_	_
3	STAT5A	stat5a	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	clearly	clearly	RB	RB	_	6	advmod	_	_
6	tyrosine	tyrosine	NN	NN	_	32	advcl	_	_
7	phosphorylated	phosphorylated	JJ	JJ	_	6	dep	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	bound	bind	VBD	VBD	_	6	conj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	enhancer	enhancer	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	32	punct	_	_
15	the	the	DT	DT	_	18	det	_	_
16	gamma	gamma	NN	NN	_	18	compound	_	_
17	response	response	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	32	nsubj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GRR	grr	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	Fc	fc	NN	NN	_	28	compound	_	_
26	gamma	gamma	NN	NN	_	28	compound	_	_
27	RI	ri	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	18	nmod	_	_
29	,	,	,	,	_	18	punct	_	_
30	substantially	substantially	RB	RB	_	31	advmod	_	_
31	less	less	JJR	JJR	_	32	advmod	_	_
32	tyrosine	tyrosine	NN	NN	_	0	root	_	_
33	phosphorylated	phosphorylated	JJ	JJ	_	32	dep	_	_
34	STAT5B	stat5b	NN	NN	_	32	dobj	_	_
35	bound	bind	VBD	VBD	_	34	acl	_	_
36	to	to	TO	TO	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	immobilized	immobilized	JJ	JJ	_	40	amod	_	_
39	GRR	grr	NN	NN	_	40	compound	_	_
40	element	element	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	32	punct	_	_

1	Macrophages	macrophage	NNS	NNS	_	2	nsubj	_	_
2	lost	lose	VBD	VBD	_	0	root	_	_
3	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	express	express	VB	VB	_	4	acl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	80-kD	80-kd	JJ	JJ	_	10	amod	_	_
9	STAT5A	stat5a	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	2	punct	_	_
12	but	but	CC	CC	_	2	cc	_	_
13	retained	retain	VBD	VBD	_	2	conj	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	activate	activate	VB	VB	_	15	acl	_	_
18	STAT5A	stat5a	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	STAT5A-STAT5A	stat5a-stat5a	JJ	JJ	_	2	amod	_	_
2	homodimers	homodimer	NNS	NNS	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	STAT5A-STAT5B	stat5a-stat5b	NN	NN	_	5	compound	_	_
5	heterodimers	heterodimer	NNS	NNS	_	2	conj	_	_
6	formed	form	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	response	response	NN	NN	_	10	dep	_	_
9	to	to	TO	TO	_	10	case	_	_
10	GM-CSF	gm-csf	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Therefore	therefore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	activation	activation	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	STAT5A	stat5a	NN	NN	_	3	nmod	_	_
6	predominates	predominate	VBZ	VBZ	_	0	root	_	_
7	compared	compare	VBN	VBN	_	9	case	_	_
8	to	to	TO	TO	_	9	case	_	_
9	STAT5B	stat5b	NN	NN	_	6	advcl	_	_
10	when	when	WRB	WRB	_	11	advmod	_	_
11	assayed	assay	VBN	VBN	_	6	advcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	direct	direct	JJ	JJ	_	14	amod	_	_
14	immunoprecipitation	immunoprecipitation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	by	by	IN	IN	_	17	case	_	_
17	evaluation	evaluation	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	bound	bind	VBN	VBN	_	20	amod	_	_
20	STATs	stats	NNS	NNS	_	17	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	immobilized	immobilized	JJ	JJ	_	23	amod	_	_
23	GRR	grr	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	STAT5	stat5	NN	NN	_	5	compound	_	_
5	homologues	homologue	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	2	cc	_	_
7	addition	addition	NN	NN	_	6	dep	_	_
8	to	to	TO	TO	_	6	dep	_	_
9	generation	generation	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	lower	lower	JJR	JJR	_	13	amod	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	isoforms	isoform	NNS	NNS	_	9	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	provide	provide	VB	VB	_	0	root	_	_
16	specificity	specificity	NN	NN	_	15	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	control	control	NN	NN	_	16	conj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	genes	gene	NNS	NNS	_	15	nmod	_	_
21	expressed	express	VBN	VBN	_	20	acl	_	_
22	in	in	IN	IN	_	25	case	_	_
23	response	response	NN	NN	_	25	dep	_	_
24	to	to	TO	TO	_	25	case	_	_
25	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
26	such	such	JJ	JJ	_	28	case	_	_
27	as	as	IN	IN	_	26	mwe	_	_
28	GM-CSF	gm-csf	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	LYSP100-associated	lysp100-associated	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	domains	domain	NNS	NNS	_	0	root	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	LANDs	land	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	:	:	:	:	_	3	punct	_	_
8	description	description	NN	NN	_	3	dep	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	class	class	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	subnuclear	subnuclear	JJ	JJ	_	15	amod	_	_
15	structures	structure	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	relationship	relationship	NN	NN	_	8	conj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	PML	pml	NN	NN	_	22	compound	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	bodies	body	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PML	pml	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	fused	fuse	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	16	case	_	_
7	the	the	DT	DT	_	16	det	_	_
8	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
9	acid	acid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	RAR	rar	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	gene	gene	NN	NN	_	5	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	t(15;17)	t(15;17)	NN	NN	_	16	nmod	_	_
19	acute	acute	JJ	JJ	_	21	amod	_	_
20	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	18	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	APL	apl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	5	punct	_	_
26	creating	create	VBG	VBG	_	5	xcomp	_	_
27	a	a	DT	DT	_	31	det	_	_
28	PML-RAR	pml-rar	NN	NN	_	31	compound	_	_
29	alpha	alpha	NN	NN	_	31	compound	_	_
30	fusion	fusion	NN	NN	_	31	compound	_	_
31	oncoprotein	oncoprotein	NN	NN	_	26	dobj	_	_
32	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	PML	pml	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	7	nsubj	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	aux	_	_
7	localized	localized	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	subnuclear	subnuclear	JJ	JJ	_	11	amod	_	_
10	dot-like	dot-like	JJ	JJ	_	11	amod	_	_
11	structures	structure	NNS	NNS	_	7	nmod	_	_
12	variously	variously	RB	RB	_	13	advmod	_	_
13	termed	term	VBN	VBN	_	11	acl	_	_
14	PODs	pod	NNS	NNS	_	13	xcomp	_	_
15	,	,	,	,	_	14	punct	_	_
16	ND10s	nd10	NNS	NNS	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	Kr	kr	NN	NN	_	19	compound	_	_
19	bodies	body	NNS	NNS	_	14	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	or	or	CC	CC	_	14	cc	_	_
22	PML	pml	NN	NN	_	24	compound	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	bodies	body	NNS	NNS	_	14	conj	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	PML	pml	NN	NN	_	27	compound	_	_
27	NBs	nb	NNS	NNS	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	describes	describe	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cloning	cloning	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	lymphoid-restricted	lymphoid-restricted	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	LYSP100	lysp100	NN	NN	_	10	appos	_	_
13	,	,	,	,	_	10	punct	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	homologous	homologous	JJ	JJ	_	10	acl:relcl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	another	another	DT	DT	_	19	det	_	_
19	protein	protein	NN	NN	_	16	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	localizes	localize	VBZ	VBZ	_	19	acl:relcl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	PML	pml	NN	NN	_	24	compound	_	_
24	NBs	nb	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	SP100	sp100	NN	NN	_	24	appos	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	addition	addition	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	SP100	sp100	NN	NN	_	6	compound	_	_
5	homology	homology	NN	NN	_	6	compound	_	_
6	regions	region	NNS	NNS	_	12	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	one	one	CD	CD	_	11	nummod	_	_
9	LYSP100	lysp100	NN	NN	_	11	compound	_	_
10	cDNA	cdna	NN	NN	_	11	compound	_	_
11	isoform	isoform	NN	NN	_	12	nsubj	_	_
12	contains	contain	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	bromodomain	bromodomain	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	PHD/TTC	phd/ttc	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	are	be	VBP	VBP	_	22	cop	_	_
22	present	present	JJ	JJ	_	14	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	variety	variety	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
28	regulatory	regulatory	JJ	JJ	_	29	amod	_	_
29	proteins	protein	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	immunofluorescence	immunofluorescence	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	LYSP100	lysp100	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	dots	dot	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	14	nsubj	_	_
11	were	be	VBD	VBD	_	14	cop	_	_
12	surprisingly	surprisingly	RB	RB	_	14	advmod	_	_
13	largely	largely	RB	RB	_	14	advmod	_	_
14	nonoverlapping	nonoverlapping	JJ	JJ	_	9	acl:relcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	PML	pml	NN	NN	_	17	compound	_	_
17	NBs	nb	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	minority	minority	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	LYSP100	lysp100	NN	NN	_	8	compound	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	dots	dot	NNS	NNS	_	4	nmod	_	_
9	exactly	exactly	RB	RB	_	10	advmod	_	_
10	colocalized	colocalize	VBD	VBD	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	PML	pml	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	SP100	sp100	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	term	term	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	LYSP100	lysp100	NN	NN	_	5	compound	_	_
5	structures	structure	NNS	NNS	_	7	dep	_	_
6	``	``	``	``	_	7	punct	_	_
7	LANDs	land	NNS	NNS	_	2	xcomp	_	_
8	,	,	,	,	_	2	punct	_	_
9	for	for	IN	IN	_	12	case	_	_
10	LYSP100-associated	lysp100-associated	JJ	JJ	_	12	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	domains	domain	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	LYSP100	lysp100	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	13	advcl	_	_
5	only	only	RB	RB	_	8	advmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	LANDs	land	NNS	NNS	_	13	nsubjpass	_	_
11	could	could	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	visualized	visualize	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HeLa	hela	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	transfection	transfection	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	LYSP100	lysp100	NN	NN	_	22	compound	_	_
22	cDNA	cdna	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Immunoelectron	immunoelectron	NN	NN	_	2	compound	_	_
2	microscopy	microscopy	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	LANDs	land	NNS	NNS	_	3	dobj	_	_
5	to	to	TO	TO	_	10	mark	_	_
6	be	be	VB	VB	_	10	cop	_	_
7	globular	globular	JJ	JJ	_	10	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	electron-dense	electron-dense	JJ	JJ	_	7	dep	_	_
10	structures	structure	NNS	NNS	_	3	xcomp	_	_
11	morphologically	morphologically	RB	RB	_	12	advmod	_	_
12	distinct	distinct	JJ	JJ	_	10	amod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	annular	annular	JJ	JJ	_	16	amod	_	_
16	structures	structure	NNS	NNS	_	12	nmod	_	_
17	characteristic	characteristic	JJ	JJ	_	16	amod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	PML	pml	NN	NN	_	20	compound	_	_
20	NBs	nb	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	LANDs	land	NNS	NNS	_	5	nsubjpass	_	_
2	were	be	VBD	VBD	_	5	auxpass	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	often	often	RB	RB	_	5	advmod	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nucleoplasm	nucleoplasm	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	but	but	CC	CC	_	5	cc	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	found	find	VBN	VBN	_	5	conj	_	_
14	at	at	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	membrane	membrane	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytoplasm	cytoplasm	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	5	punct	_	_
23	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	these	these	DT	DT	_	26	det	_	_
26	structures	structure	NNS	NNS	_	28	nsubj	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	traffic	traffic	VBP	VBP	_	23	ccomp	_	_
29	between	between	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	cytoplasm	cytoplasm	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	double-immunogold	double-immunogold	JJ	JJ	_	3	amod	_	_
3	labeling	labeling	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	PML	pml	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	LYSP100	lysp100	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	some	some	DT	DT	_	10	det	_	_
10	LANDs	land	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	contain	contain	VB	VB	_	12	xcomp	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	PML	pml	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	LYSP100	lysp100	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PML	pml	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	aux	_	_
5	localized	localized	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	10	dep	_	_
7	a	a	DT	DT	_	10	det	_	_
8	second	second	JJ	JJ	_	10	amod	_	_
9	subnuclear	subnuclear	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	5	dobj	_	_
11	that	that	WDT	WDT	_	16	nsubj	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	morphologically	morphologically	RB	RB	_	14	advmod	_	_
14	and	and	CC	CC	_	16	advmod	_	_
15	biochemically	biochemically	RB	RB	_	14	advmod	_	_
16	distinct	distinct	JJ	JJ	_	10	acl:relcl	_	_
17	from	from	IN	IN	_	19	case	_	_
18	PML	pml	NN	NN	_	19	compound	_	_
19	NBs	nb	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	p16	p16	NN	NN	_	8	compound	_	_
4	,	,	,	,	_	3	punct	_	_
5	p15	p15	NN	NN	_	3	conj	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	CDK4	cdk4	NN	NN	_	3	conj	_	_
8	genes	gene	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	recurrent	recurrent	JJ	JJ	_	12	amod	_	_
11	malignant	malignant	JJ	JJ	_	12	amod	_	_
12	astrocytomas	astrocytoma	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	23	nsubjpass	_	_
2	in	in	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	p16	p16	NN	NN	_	9	compound	_	_
5	,	,	,	,	_	4	punct	_	_
6	p15	p15	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	CDK4	cdk4	NN	NN	_	4	conj	_	_
9	genes	gene	NNS	NNS	_	1	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	regulate	regulate	VBP	VBP	_	9	acl:relcl	_	_
12	transition	transition	NN	NN	_	11	dobj	_	_
13	through	through	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	G1	g1	NN	NN	_	16	compound	_	_
16	phase	phase	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	cycle	cycle	NN	NN	_	16	nmod	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	implicated	implicate	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	malignant	malignant	JJ	JJ	_	27	amod	_	_
27	progression	progression	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	astrocytomas	astrocytoma	NNS	NNS	_	27	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	dysfunction	dysfunction	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	occurs	occur	VBZ	VBZ	_	7	ccomp	_	_
15	during	during	IN	IN	_	16	case	_	_
16	recurrence	recurrence	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	glial	glial	JJ	JJ	_	19	amod	_	_
19	tumors	tumor	NNS	NNS	_	16	nmod	_	_
20	that	that	WDT	WDT	_	23	nsubj	_	_
21	were	be	VBD	VBD	_	23	cop	_	_
22	highly	highly	RB	RB	_	23	advmod	_	_
23	malignant	malignant	JJ	JJ	_	19	acl:relcl	_	_
24	at	at	IN	IN	_	26	case	_	_
25	first	first	JJ	JJ	_	26	amod	_	_
26	presentation	presentation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Analysis	analysis	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	10	10	CD	CD	_	5	nummod	_	_
4	matched	match	VBN	VBN	_	5	amod	_	_
5	pairs	pair	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	high	high	JJ	JJ	_	10	amod	_	_
8	grade	grade	NN	NN	_	10	compound	_	_
9	malignant	malignant	JJ	JJ	_	10	amod	_	_
10	astrocytomas	astrocytoma	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
13	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
14	recurrences	recurrence	NNS	NNS	_	10	conj	_	_
15	identified	identify	VBD	VBD	_	0	root	_	_
16	three	three	CD	CD	_	18	nummod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	groups	group	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	primary	primary	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	recurrent	recurrent	JJ	JJ	_	2	conj	_	_
5	tumors	tumor	NNS	NNS	_	11	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Group	group	NN	NN	_	8	compound	_	_
8	A	a	NN	NN	_	5	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	show	show	VB	VB	_	0	root	_	_
12	structural	structural	JJ	JJ	_	13	amod	_	_
13	alterations	alteration	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	p16	p16	NN	NN	_	21	compound	_	_
17	,	,	,	,	_	16	punct	_	_
18	p15	p15	NN	NN	_	16	conj	_	_
19	or	or	CC	CC	_	16	cc	_	_
20	CDK4	cdk4	NN	NN	_	16	conj	_	_
21	genes	gene	NNS	NNS	_	13	nmod	_	_
22	,	,	,	,	_	11	punct	_	_
23	whereas	whereas	IN	IN	_	11	dep	_	_
24	homozygous	homozygous	JJ	JJ	_	25	amod	_	_
25	codeletion	codeletion	NN	NN	_	31	nsubjpass	_	_
26	of	of	IN	IN	_	27	case	_	_
27	p16	p16	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	p15	p15	NN	NN	_	27	conj	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	observed	observe	VBN	VBN	_	11	parataxis	_	_
32	in	in	IN	IN	_	37	case	_	_
33	both	both	CC	CC	_	34	cc:preconj	_	_
34	primary	primary	JJ	JJ	_	37	amod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	recurrent	recurrent	JJ	JJ	_	34	conj	_	_
37	tumors	tumor	NNS	NNS	_	31	nmod	_	_
38	in	in	IN	IN	_	40	case	_	_
39	Group	group	NN	NN	_	40	compound	_	_
40	B	b	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	primary	primary	JJ	JJ	_	3	amod	_	_
3	tumors	tumor	NNS	NNS	_	7	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	Group	group	NN	NN	_	6	compound	_	_
6	C	c	NN	NN	_	3	nmod	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	profile	profile	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	p16	p16	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	p15	p15	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	CDK4	cdk4	NN	NN	_	12	conj	_	_
17	at	at	IN	IN	_	18	case	_	_
18	presentation	presentation	NN	NN	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	recurrence	recurrence	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	however	however	RB	RB	_	8	advmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	tumors	tumor	NNS	NNS	_	8	nsubj	_	_
8	sustained	sustain	VBD	VBD	_	0	root	_	_
9	either	either	CC	CC	_	10	cc:preconj	_	_
10	deletion	deletion	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	p16	p16	NN	NN	_	10	nmod	_	_
13	alone	alone	RB	RB	_	12	advmod	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	codeletion	codeletion	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	p16	p16	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p15	p15	NN	NN	_	18	conj	_	_
21	or	or	CC	CC	_	10	cc	_	_
22	amplification	amplification	NN	NN	_	10	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	CDK4	cdk4	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Analysis	analysis	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	differences	difference	NNS	NNS	_	1	nmod	_	_
6	between	between	IN	IN	_	9	case	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	anaplastic	anaplastic	JJ	JJ	_	9	amod	_	_
9	astrocytomas/glioblastomas	astrocytomas/glioblastomas	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
12	subsequent	subsequent	JJ	JJ	_	13	amod	_	_
13	recurrences	recurrence	NNS	NNS	_	9	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	which	which	WDT	WDT	_	18	nsubj	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	clinically	clinically	RB	RB	_	18	advmod	_	_
18	indistinguishable	indistinguishable	JJ	JJ	_	5	acl:relcl	_	_
19	,	,	,	,	_	5	punct	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	provide	provide	VB	VB	_	0	root	_	_
22	better	better	JJR	JJR	_	24	amod	_	_
23	therapeutic	therapeutic	JJ	JJ	_	24	amod	_	_
24	options	option	NNS	NNS	_	21	dobj	_	_
25	for	for	IN	IN	_	26	case	_	_
26	treatment	treatment	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	21	punct	_	_

1	CTL	ctl	NN	NN	_	2	compound	_	_
2	recognition	recognition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	altered	altered	JJ	JJ	_	6	amod	_	_
6	peptide	peptide	NN	NN	_	2	nmod	_	_
7	associated	associate	VBN	VBN	_	2	acl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	asparagine	asparagine	NN	NN	_	11	compound	_	_
10	bond	bond	NN	NN	_	11	compound	_	_
11	rearrangement	rearrangement	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Implications	implication	NNS	NNS	_	0	root	_	_
2	for	for	IN	IN	_	3	case	_	_
3	immunity	immunity	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	vaccine	vaccine	NN	NN	_	6	compound	_	_
6	design	design	NN	NN	_	3	conj	_	_
7	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	extent	extent	NN	NN	_	24	nsubjpass	_	_
3	to	to	TO	TO	_	4	case	_	_
4	which	which	WDT	WDT	_	16	nmod	_	_
5	peptides	peptide	NNS	NNS	_	16	nsubjpass	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	chemically	chemically	RB	RB	_	8	advmod	_	_
8	and	and	CC	CC	_	10	advmod	_	_
9	post-translationally	post-translationally	RB	RB	_	8	advmod	_	_
10	modified	modify	VBN	VBN	_	14	amod	_	_
11	amino	amino	NN	NN	_	14	compound	_	_
12	acid	acid	NN	NN	_	14	compound	_	_
13	side	side	JJ	JJ	_	14	amod	_	_
14	chains	chain	NNS	NNS	_	6	dobj	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	recognized	recognize	VBN	VBN	_	2	acl:relcl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	primed	primed	JJ	JJ	_	19	amod	_	_
19	CTL	ctl	NN	NN	_	16	nmod	_	_
20	has	have	VBZ	VBZ	_	24	aux	_	_
21	not	not	RB	RB	_	24	neg	_	_
22	been	be	VBN	VBN	_	24	auxpass	_	_
23	clearly	clearly	RB	RB	_	24	advmod	_	_
24	defined	define	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	on	on	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CTL	ctl	NN	NN	_	6	compound	_	_
6	recognition	recognition	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	MHC	mhc	NN	NN	_	11	nmod:npmod	_	_
10	class	class	NN	NN	_	11	nmod:npmod	_	_
11	I-restricted	i-restricted	JJ	JJ	_	12	amod	_	_
12	peptide	peptide	NN	NN	_	6	nmod	_	_
13	containing	contain	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	20	det	_	_
15	cyclized	cyclized	JJ	JJ	_	16	amod	_	_
16	asparagine	asparagine	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	succinimide	succinimide	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	residue	residue	NN	NN	_	13	dobj	_	_
21	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	modification	modification	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	asparagine	asparagine	NN	NN	_	7	compound	_	_
6	side	side	JJ	JJ	_	7	amod	_	_
7	chain	chain	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	common	common	JJ	JJ	_	12	amod	_	_
11	intermediate	intermediate	JJ	JJ	_	12	amod	_	_
12	structure	structure	NN	NN	_	0	root	_	_
13	during	during	IN	IN	_	14	case	_	_
14	deamidation	deamidation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	isomerization	isomerization	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	bond	bond	NN	NN	_	20	compound	_	_
20	rearrangements	rearrangement	NNS	NNS	_	14	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	amide-containing	amide-containing	JJ	JJ	_	24	amod	_	_
23	amino	amino	NN	NN	_	24	compound	_	_
24	acids	acid	NNS	NNS	_	14	nmod	_	_
25	and	and	CC	CC	_	12	cc	_	_
26	also	also	RB	RB	_	12	advmod	_	_
27	occurs	occur	VBZ	VBZ	_	12	dep	_	_
28	as	as	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	side	side	JJ	JJ	_	31	amod	_	_
31	reaction	reaction	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	peptide	peptide	NN	NN	_	34	compound	_	_
34	synthesis	synthesis	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	CTL	ctl	NN	NN	_	4	nsubj	_	_
3	specifically	specifically	RB	RB	_	4	advmod	_	_
4	recognized	recognize	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	succinimide-containing	succinimide-containing	JJ	JJ	_	7	amod	_	_
7	peptide	peptide	NN	NN	_	4	dobj	_	_
8	showing	show	VBG	VBG	_	7	acl	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	weak	weak	JJ	JJ	_	11	amod	_	_
11	cross-reactivity	cross-reactivity	NN	NN	_	8	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	parent	parent	NN	NN	_	18	compound	_	_
18	peptide	peptide	NN	NN	_	14	nmod	_	_
19	containing	contain	VBG	VBG	_	18	acl	_	_
20	unmodified	unmodified	JJ	JJ	_	21	amod	_	_
21	asparagine	asparagine	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Similarly	similarly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	CTL	ctl	NN	NN	_	11	nsubj	_	_
4	raised	raise	VBN	VBN	_	3	acl	_	_
5	against	against	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	parent	parent	NN	NN	_	8	compound	_	_
8	peptide	peptide	NN	NN	_	4	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	recognize	recognize	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	succinimide	succinimide	JJ	JJ	_	14	amod	_	_
14	derivative	derivative	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	peptide	peptide	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Naturally	naturally	RB	RB	_	2	advmod	_	_
2	processed	process	VBN	VBN	_	3	amod	_	_
3	forms	form	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	structures	structure	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	likely	likely	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	occur	occur	VB	VB	_	8	xcomp	_	_
11	given	give	VBN	VBN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	importance	importance	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	frequency	frequency	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	deamidation	deamidation	NN	NN	_	13	nmod	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	21	advmod	_	_
21	and	and	CC	CC	_	13	advmod	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vivo	vivo	FW	FW	_	21	advmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	since	since	IN	IN	_	13	mark	_	_
4	succinimide	succinimide	NN	NN	_	5	compound	_	_
5	intermediates	intermediate	NNS	NNS	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	deamidated	deamidate	VBN	VBN	_	8	amod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	can	can	MD	MD	_	13	aux	_	_
10	occasionally	occasionally	RB	RB	_	13	advmod	_	_
11	be	be	VB	VB	_	13	cop	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	stable	stable	JJ	JJ	_	17	advcl	_	_
14	,	,	,	,	_	17	punct	_	_
15	these	these	DT	DT	_	16	det	_	_
16	peptides	peptide	NNS	NNS	_	17	nsubj	_	_
17	have	have	VBP	VBP	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	potential	potential	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	act	act	VB	VB	_	19	acl	_	_
22	as	as	IN	IN	_	24	case	_	_
23	altered	altered	JJ	JJ	_	24	amod	_	_
24	self-Ags	self-ag	NNS	NNS	_	21	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	significant	significant	JJ	JJ	_	27	amod	_	_
27	implications	implication	NNS	NNS	_	24	nmod	_	_
28	for	for	IN	IN	_	29	case	_	_
29	autoimmunity	autoimmunity	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	unwanted	unwanted	JJ	JJ	_	8	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	potentially	potentially	RB	RB	_	7	advmod	_	_
7	hazardous	hazardous	JJ	JJ	_	4	conj	_	_
8	specificities	specificity	NNS	NNS	_	11	nsubjpass	_	_
9	may	may	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	elicited	elicit	VBN	VBN	_	0	root	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	using	use	VBG	VBG	_	11	advcl	_	_
14	synthetic	synthetic	JJ	JJ	_	15	amod	_	_
15	peptides	peptide	NNS	NNS	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	subunit	subunit	NN	NN	_	18	compound	_	_
18	vaccines	vaccine	NNS	NNS	_	13	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	24	nmod	_	_
21	succinimide	succinimide	NN	NN	_	22	compound	_	_
22	residues	residue	NNS	NNS	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	form	form	VB	VB	_	18	acl:relcl	_	_
25	spontaneously	spontaneously	RB	RB	_	24	advmod	_	_
26	during	during	IN	IN	_	27	case	_	_
27	storage	storage	NN	NN	_	24	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	chemical	chemical	JJ	JJ	_	30	amod	_	_
30	synthesis	synthesis	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	11	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	at	at	IN	IN	_	7	case	_	_
6	early	early	JJ	JJ	_	7	amod	_	_
7	stages	stage	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	B-cell	b-cell	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	T-cell	t-cell	NN	NN	_	9	conj	_	_
12	differentiation	differentiation	NN	NN	_	9	dep	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	sets	set	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	genes	gene	NNS	NNS	_	5	nmod	_	_
8	at	at	IN	IN	_	10	case	_	_
9	different	different	JJ	JJ	_	10	amod	_	_
10	stages	stage	NNS	NNS	_	2	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	B-lymphocyte	b-lymphocyte	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	T-lymphocyte	t-lymphocyte	NN	NN	_	12	conj	_	_
15	differentiation	differentiation	NN	NN	_	12	dep	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	controlled	control	VBN	VBN	_	0	root	_	_
18	at	at	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	level	level	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	recent	recent	JJ	JJ	_	5	amod	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	described	describe	VBN	VBN	_	0	root	_	_
8	interactions	interaction	NNS	NNS	_	7	dobj	_	_
9	between	between	IN	IN	_	11	case	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	provide	provide	VBP	VBP	_	8	acl:relcl	_	_
16	new	new	JJ	JJ	_	17	amod	_	_
17	insights	insight	NNS	NNS	_	15	dobj	_	_
18	into	into	IN	IN	_	19	case	_	_
19	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
20	regulating	regulate	VBG	VBG	_	19	acl	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	3	nsubj	_	_
3	include	include	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	assembly	assembly	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	higher	higher	JJR	JJR	_	10	amod	_	_
8	order	order	NN	NN	_	10	compound	_	_
9	nucleoprotein	nucleoprotein	NN	NN	_	10	compound	_	_
10	complexes	complex	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	protein-protein	protein-protein	JJ	JJ	_	14	amod	_	_
14	interactions	interaction	NNS	NNS	_	5	conj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	enhance	enhance	VBP	VBP	_	5	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	specificity	specificity	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	regulators	regulator	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	X	x	NN	NN	_	3	compound	_	_
2	inactivation	inactivation	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	female	female	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	hypomelanosis	hypomelanosis	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Ito	ito	NN	NN	_	8	nmod	_	_
11	associated	associate	VBN	VBN	_	8	acl	_	_
12	with	with	IN	IN	_	18	case	_	_
13	a	a	DT	DT	_	18	det	_	_
14	balanced	balanced	JJ	JJ	_	18	amod	_	_
15	X	x	NN	NN	_	18	compound	_	_
16	;	;	:	:	_	18	punct	_	_
17	17	17	CD	CD	_	18	nummod	_	_
18	translocation	translocation	NN	NN	_	11	nmod	_	_
19	:	:	:	:	_	3	punct	_	_
20	evidence	evidence	NN	NN	_	3	dep	_	_
21	for	for	IN	IN	_	23	case	_	_
22	functional	functional	JJ	JJ	_	23	amod	_	_
23	disomy	disomy	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	Xp	xp	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	X	x	NN	NN	_	3	compound	_	_
2	inactivation	inactivation	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	performed	perform	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	normal	normal	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	hypopigmented	hypopigmented	JJ	JJ	_	7	conj	_	_
10	skin	skin	NN	NN	_	11	compound	_	_
11	samples	sample	NNS	NNS	_	7	dep	_	_
12	obtained	obtain	VBN	VBN	_	7	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	female	female	NN	NN	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	hypomelanosis	hypomelanosis	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Ito	ito	NN	NN	_	17	nmod	_	_
20	associated	associate	VBN	VBN	_	17	acl	_	_
21	with	with	IN	IN	_	29	case	_	_
22	a	a	DT	DT	_	29	det	_	_
23	balanced	balanced	JJ	JJ	_	29	amod	_	_
24	whole	whole	JJ	JJ	_	29	amod	_	_
25	arm	arm	NN	NN	_	29	compound	_	_
26	X	x	NN	NN	_	29	compound	_	_
27	;	;	:	:	_	29	punct	_	_
28	17	17	CD	CD	_	29	nummod	_	_
29	translocation	translocation	NN	NN	_	20	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Severe	severe	JJ	JJ	_	2	amod	_	_
2	skewing	skewing	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	X	x	NN	NN	_	5	compound	_	_
5	inactivation	inactivation	NN	NN	_	2	nmod	_	_
6	resulting	result	VBG	VBG	_	2	acl	_	_
7	in	in	IN	IN	_	8	case	_	_
8	inactivity	inactivity	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	intact	intact	JJ	JJ	_	12	amod	_	_
12	X	x	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	blood	blood	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cultures	culture	NNS	NNS	_	16	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	both	both	DT	DT	_	21	det	_	_
21	types	type	NNS	NNS	_	16	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	skin	skin	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	but	but	CC	CC	_	14	cc	_	_
26	analysis	analysis	NN	NN	_	34	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	DNA	dna	NN	NN	_	26	nmod	_	_
29	prepared	prepare	VBN	VBN	_	28	acl	_	_
30	directly	directly	RB	RB	_	33	advmod	_	_
31	from	from	IN	IN	_	33	case	_	_
32	hypopigmented	hypopigmented	JJ	JJ	_	33	amod	_	_
33	skin	skin	NN	NN	_	29	nmod	_	_
34	showed	show	VBD	VBD	_	14	conj	_	_
35	significant	significant	JJ	JJ	_	36	amod	_	_
36	inactivation	inactivation	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	translocated	translocate	VBN	VBN	_	40	amod	_	_
40	X	x	NN	NN	_	36	nmod	_	_
41	,	,	,	,	_	34	punct	_	_
42	inconsistent	inconsistent	JJ	JJ	_	34	advmod	_	_
43	with	with	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	usual	usual	JJ	JJ	_	46	amod	_	_
46	mechanism	mechanism	NN	NN	_	42	nmod	_	_
47	of	of	IN	IN	_	49	case	_	_
48	phenotypic	phenotypic	JJ	JJ	_	49	amod	_	_
49	expression	expression	NN	NN	_	46	nmod	_	_
50	in	in	IN	IN	_	54	case	_	_
51	X	x	NN	NN	_	54	compound	_	_
52	;	;	:	:	_	54	punct	_	_
53	autosome	autosome	JJ	JJ	_	54	amod	_	_
54	translocations	translocation	NNS	NNS	_	49	nmod	_	_
55	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	dual	dual	JJ	JJ	_	7	amod	_	_
5	colour	colour	NN	NN	_	7	compound	_	_
6	FISH	fish	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	17	nsubj	_	_
8	using	use	VBG	VBG	_	7	acl	_	_
9	centromere	centromere	NN	NN	_	11	compound	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	probes	probe	NNS	NNS	_	8	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	chromosomes	chromosome	NNS	NNS	_	11	nmod	_	_
14	X	x	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	17	17	CD	CD	_	14	conj	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	breakpoints	breakpoint	NNS	NNS	_	24	nsubj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	both	both	DT	DT	_	23	dep	_	_
23	chromosomes	chromosome	NNS	NNS	_	20	nmod	_	_
24	lie	lie	VBP	VBP	_	17	ccomp	_	_
25	within	within	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	alphoid	alphoid	JJ	JJ	_	28	amod	_	_
28	arrays	array	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	making	make	VBG	VBG	_	24	xcomp	_	_
31	interruption	interruption	NN	NN	_	38	nsubj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	locus	locus	NN	NN	_	31	nmod	_	_
35	on	on	IN	IN	_	37	case	_	_
36	either	either	DT	DT	_	37	det	_	_
37	chromosome	chromosome	NN	NN	_	34	nmod	_	_
38	unlikely	unlikely	JJ	JJ	_	30	xcomp	_	_
39	.	.	.	.	_	17	punct	_	_

1	While	while	IN	IN	_	13	mark	_	_
2	partial	partial	JJ	JJ	_	4	amod	_	_
3	variable	variable	JJ	JJ	_	2	dep	_	_
4	monosomy	monosomy	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	loci	locus	NNS	NNS	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	chromosome	chromosome	NN	NN	_	9	compound	_	_
9	17p	17p	NN	NN	_	6	nmod	_	_
10	can	can	MD	MD	_	13	aux	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	excluded	exclude	VBN	VBN	_	25	advcl	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	contributing	contribute	VBG	VBG	_	13	advcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	phenotype	phenotype	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	patient	patient	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	it	it	PRP	PRP	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	argued	argue	VBN	VBN	_	0	root	_	_
26	that	that	IN	IN	_	34	mark	_	_
27	the	the	DT	DT	_	30	det	_	_
28	major	major	JJ	JJ	_	30	amod	_	_
29	likely	likely	JJ	JJ	_	28	dep	_	_
30	factor	factor	NN	NN	_	34	nsubj	_	_
31	is	be	VBZ	VBZ	_	34	cop	_	_
32	partial	partial	JJ	JJ	_	34	amod	_	_
33	functional	functional	JJ	JJ	_	32	dep	_	_
34	disomy	disomy	NN	NN	_	25	ccomp	_	_
35	of	of	IN	IN	_	36	case	_	_
36	sequences	sequence	NNS	NNS	_	34	nmod	_	_
37	on	on	IN	IN	_	38	case	_	_
38	Xp	xp	NN	NN	_	36	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	lineages	lineage	NNS	NNS	_	38	nmod	_	_
42	that	that	WDT	WDT	_	44	nsubj	_	_
43	have	have	VBP	VBP	_	44	aux	_	_
44	failed	fail	VBN	VBN	_	34	acl:relcl	_	_
45	to	to	TO	TO	_	46	mark	_	_
46	inactivate	inactivate	VB	VB	_	44	xcomp	_	_
47	the	the	DT	DT	_	50	det	_	_
48	intact	intact	JJ	JJ	_	50	amod	_	_
49	X	x	NN	NN	_	50	compound	_	_
50	chromosome	chromosome	NN	NN	_	46	dobj	_	_
51	.	.	.	.	_	25	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	0	root	_	_
4	involved	involve	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	member	member	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	steroid	steroid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	superfamily	superfamily	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	related	related	JJ	JJ	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	1	conj	_	_
6	constitute	constitute	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	family	family	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	13	nsubj	_	_
13	consists	consist	VBZ	VBZ	_	6	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	three	three	CD	CD	_	16	nummod	_	_
16	subtypes	subtype	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	named	name	VBN	VBN	_	16	acl	_	_
19	nur77	nur77	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	18	xcomp	_	_
21	,	,	,	,	_	20	punct	_	_
22	nur77	nur77	NN	NN	_	23	compound	_	_
23	beta	beta	NN	NN	_	20	appos	_	_
24	,	,	,	,	_	20	punct	_	_
25	nur77	nur77	NN	NN	_	26	compound	_	_
26	gamma	gamma	NN	NN	_	20	appos	_	_
27	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	cloned	clone	VBD	VBD	_	0	root	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	nur77	nur77	NN	NN	_	6	compound	_	_
5	beta	beta	NN	NN	_	6	compound	_	_
6	cDNA	cdna	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	called	call	VBN	VBN	_	6	acl	_	_
9	TINUR	tinur	NN	NN	_	8	xcomp	_	_
10	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	essential	essential	JJ	JJ	_	24	advcl	_	_
5	for	for	IN	IN	_	7	case	_	_
6	TCR-mediated	tcr-mediated	JJ	JJ	_	7	amod	_	_
7	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	hybridomas	hybridoma	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	24	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	reports	report	NNS	NNS	_	24	nsubj	_	_
14	on	on	IN	IN	_	17	case	_	_
15	nur77	nur77	NN	NN	_	17	compound	_	_
16	knock-out	knock-out	JJ	JJ	_	17	amod	_	_
17	mice	mouse	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	nur77	nur77	NN	NN	_	23	compound	_	_
20	dominant	dominant	JJ	JJ	_	23	amod	_	_
21	negative	negative	JJ	JJ	_	23	amod	_	_
22	transgenic	transgenic	JJ	JJ	_	23	amod	_	_
23	mice	mouse	NNS	NNS	_	17	conj	_	_
24	suggest	suggest	VBP	VBP	_	0	root	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	there	there	EX	EX	_	27	expl	_	_
27	is	be	VBZ	VBZ	_	24	ccomp	_	_
28	a	a	DT	DT	_	30	det	_	_
29	functional	functional	JJ	JJ	_	30	amod	_	_
30	redundancy	redundancy	NN	NN	_	27	nsubj	_	_
31	among	among	IN	IN	_	33	case	_	_
32	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	33	compound	_	_
33	family	family	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	24	punct	_	_

1	NGFI-B/nur77	ngfi-b/nur77	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	response	response	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	monomer	monomer	NN	NN	_	2	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	heterodimer	heterodimer	NN	NN	_	8	conj	_	_
11	with	with	IN	IN	_	14	case	_	_
12	retinoid	retinoid	NN	NN	_	14	compound	_	_
13	X	x	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	RXR	rxr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	2	punct	_	_

1	Assuming	assume	VBG	VBG	_	8	case	_	_
2	that	that	IN	IN	_	8	mark	_	_
3	9-cis-retinoic	9-cis-retinoic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	9-cis-RA	9-cis-ra	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	inhibits	inhibit	VBZ	VBZ	_	14	advcl	_	_
9	TCR-mediated	tcr-mediated	JJ	JJ	_	10	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	14	punct	_	_
12	nur77	nur77	NNS	NNS	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	cause	cause	VB	VB	_	0	root	_	_
15	apoptosis	apoptosis	NN	NN	_	14	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	monomer	monomer	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	dep	_	_
20	absence	absence	NN	NN	_	22	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	9-cis-RA	9-cis-ra	NN	NN	_	14	nmod	_	_
23	and	and	CC	CC	_	14	cc	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	inhibit	inhibit	VB	VB	_	14	conj	_	_
26	apoptosis	apoptosis	NN	NN	_	25	dobj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	heterodimer	heterodimer	NN	NN	_	25	nmod	_	_
29	with	with	IN	IN	_	30	case	_	_
30	RXR	rxr	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	dep	_	_
33	presence	presence	NN	NN	_	35	dep	_	_
34	of	of	IN	IN	_	35	case	_	_
35	9-cis-RA	9-cis-ra	NN	NN	_	25	nmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	Interaction	interaction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	11	case	_	_
3	the	the	DT	DT	_	11	det	_	_
4	human	human	JJ	JJ	_	11	amod	_	_
5	T-cell	t-cell	NN	NN	_	11	compound	_	_
6	lymphotropic	lymphotropic	JJ	JJ	_	11	amod	_	_
7	virus	virus	NN	NN	_	11	compound	_	_
8	type	type	NN	NN	_	11	compound	_	_
9	1	1	CD	CD	_	11	nummod	_	_
10	tax	tax	NN	NN	_	11	compound	_	_
11	transactivator	transactivator	NN	NN	_	1	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	IIA	iia	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	T-cell	t-cell	NN	NN	_	9	compound	_	_
7	lymphotropic	lymphotropic	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	3	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HTLV-1	htlv-1	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	18	cop	_	_
15	a	a	DT	DT	_	18	det	_	_
16	40-kDa	40-kda	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activator	activator	NN	NN	_	0	root	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	critical	critical	JJ	JJ	_	18	acl:relcl	_	_
22	for	for	IN	IN	_	25	case	_	_
23	HTLV-1	htlv-1	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	regulation	regulation	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	virus-induced	virus-induced	JJ	JJ	_	29	amod	_	_
28	cellular	cellular	JJ	JJ	_	29	amod	_	_
29	transformation	transformation	NN	NN	_	25	conj	_	_
30	.	.	.	.	_	18	punct	_	_

1	Tax	tax	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	aux	_	_
3	localized	localized	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	DNA	dna	NN	NN	_	3	nmod	_	_
7	through	through	IN	IN	_	9	case	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	interaction	interaction	NN	NN	_	3	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	site-specific	site-specific	JJ	JJ	_	13	amod	_	_
13	activators	activator	NNS	NNS	_	9	nmod	_	_
14	cyclic	cyclic	JJ	JJ	_	16	amod	_	_
15	AMP-responsive	amp-responsive	JJ	JJ	_	16	amod	_	_
16	element-binding	element-binding	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	13	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	serum	serum	NN	NN	_	24	compound	_	_
23	response	response	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	17	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	recruitment	recruitment	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Tax	tax	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	DNA	dna	NN	NN	_	7	nmod	_	_
13	positions	position	VBZ	VBZ	_	4	ccomp	_	_
14	Tax	tax	NN	NN	_	13	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	interaction	interaction	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	basal	basal	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	machinery	machinery	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	On	on	IN	IN	_	7	case	_	_
2	the	the	DT	DT	_	7	dep	_	_
3	basis	basis	NN	NN	_	7	dep	_	_
4	of	of	IN	IN	_	7	case	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	independent	independent	JJ	JJ	_	7	amod	_	_
7	assays	assay	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	we	we	PRP	PRP	_	11	nsubj	_	_
10	now	now	RB	RB	_	11	advmod	_	_
11	report	report	VBP	VBP	_	0	root	_	_
12	a	a	DT	DT	_	16	det	_	_
13	physical	physical	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	functional	functional	JJ	JJ	_	13	conj	_	_
16	interaction	interaction	NN	NN	_	11	dobj	_	_
17	between	between	IN	IN	_	18	case	_	_
18	Tax	tax	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	18	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	TFIIA	tfiia	NN	NN	_	22	appos	_	_
25	.	.	.	.	_	11	punct	_	_

1	First	first	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Tax	tax	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	interact	interact	VB	VB	_	5	xcomp	_	_
8	with	with	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	35-kDa	35-kda	JJ	JJ	_	14	amod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	alpha	alpha	NN	NN	_	10	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	subunit	subunit	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TFIIA	tfiia	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	yeast	yeast	NN	NN	_	22	compound	_	_
20	two-hybrid	two-hybrid	JJ	JJ	_	22	amod	_	_
21	interaction	interaction	NN	NN	_	22	compound	_	_
22	system	system	NN	NN	_	7	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Importantly	importantly	RB	RB	_	37	advmod	_	_
2	,	,	,	,	_	37	punct	_	_
3	two	two	CD	CD	_	6	nummod	_	_
4	previously	previously	RB	RB	_	5	advmod	_	_
5	characterized	characterize	VBN	VBN	_	6	amod	_	_
6	mutants	mutant	NNS	NNS	_	37	nsubj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	point	point	NN	NN	_	9	compound	_	_
9	mutations	mutation	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	Tax	tax	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	M32	m32	NN	NN	_	11	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Y196A	y196a	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	K197S	k197s	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	M41	m41	NN	NN	_	11	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	H287A	h287a	NN	NN	_	20	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	P288S	p288s	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	,	,	,	,	_	6	punct	_	_
27	which	which	WDT	WDT	_	29	nsubjpass	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	shown	show	VBN	VBN	_	6	acl:relcl	_	_
30	to	to	TO	TO	_	32	mark	_	_
31	be	be	VB	VB	_	32	cop	_	_
32	defective	defective	JJ	JJ	_	29	xcomp	_	_
33	in	in	IN	IN	_	35	case	_	_
34	Tax-activated	tax-activated	JJ	JJ	_	35	amod	_	_
35	transcription	transcription	NN	NN	_	32	nmod	_	_
36	were	be	VBD	VBD	_	37	cop	_	_
37	unable	unable	JJ	JJ	_	0	root	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	interact	interact	VB	VB	_	37	xcomp	_	_
40	with	with	IN	IN	_	41	case	_	_
41	TFIIA	tfiia	NN	NN	_	39	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	this	this	DT	DT	_	44	det	_	_
44	assay	assay	NN	NN	_	39	nmod	_	_
45	.	.	.	.	_	37	punct	_	_

1	Second	second	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	9	det	_	_
4	glutathione-S-transferase	glutathione-s-transferase	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GST	gst	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	affinity-binding	affinity-binding	JJ	JJ	_	9	amod	_	_
9	assay	assay	NN	NN	_	10	nsubj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	20	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	interaction	interaction	NN	NN	_	20	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	holo-TFIIA	holo-tfiia	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	GST-Tax	gst-tax	NN	NN	_	13	nmod	_	_
18	was	be	VBD	VBD	_	20	cop	_	_
19	20-fold	20-fold	RB	RB	_	20	advmod	_	_
20	higher	higher	JJR	JJR	_	10	ccomp	_	_
21	than	than	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	observed	observe	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	30	case	_	_
25	either	either	CC	CC	_	30	cc:preconj	_	_
26	the	the	DT	DT	_	30	det	_	_
27	GST-Tax	gst-tax	NN	NN	_	30	compound	_	_
28	M32	m32	NN	NN	_	30	compound	_	_
29	activation	activation	NN	NN	_	30	compound	_	_
30	mutant	mutant	NN	NN	_	23	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	34	det	_	_
33	GST	gst	NN	NN	_	34	compound	_	_
34	control	control	NN	NN	_	30	conj	_	_
35	.	.	.	.	_	10	punct	_	_

1	Third	third	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	coimmunoprecipitation	coimmunoprecipitation	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	6	nsubj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	in	in	IN	IN	_	12	case	_	_
9	HTLV-1-infected	htlv-1-infected	JJ	JJ	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
13	,	,	,	,	_	18	punct	_	_
14	Tax	tax	NN	NN	_	18	nsubjpass	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	TFIIA	tfiia	NN	NN	_	14	conj	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	6	ccomp	_	_
19	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	TFIIA	tfiia	NN	NN	_	4	nsubj	_	_
4	facilitates	facilitate	NNS	NNS	_	0	root	_	_
5	Tax	tax	NN	NN	_	6	compound	_	_
6	transactivation	transactivation	NN	NN	_	4	dobj	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	9	advmod	_	_
9	and	and	CC	CC	_	4	advmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	9	advmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	reduced	reduce	VBN	VBN	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Tax-activated	tax-activated	JJ	JJ	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	extracts	extract	NNS	NNS	_	7	nmod	_	_
14	depleted	deplete	VBN	VBN	_	13	acl	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TFIIA	tfiia	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	transfection	transfection	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	TFIIA	tfiia	NN	NN	_	12	compound	_	_
11	expression	expression	NN	NN	_	12	compound	_	_
12	vectors	vector	NNS	NNS	_	4	nmod	_	_
13	enhanced	enhance	VBD	VBD	_	0	root	_	_
14	Tax-activated	tax-activated	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	24	case	_	_
17	an	a	DT	DT	_	24	det	_	_
18	HTLV-1	htlv-1	NN	NN	_	23	nmod:npmod	_	_
19	long	long	JJ	JJ	_	23	amod	_	_
20	terminal	terminal	JJ	JJ	_	23	amod	_	_
21	repeat-chloramphenicol	repeat-chloramphenicol	NN	NN	_	23	dep	_	_
22	acetyltransferase	acetyltransferase	NN	NN	_	23	dep	_	_
23	reporter	reporter	NN	NN	_	24	amod	_	_
24	construct	construct	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	interaction	interaction	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Tax	tax	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	TFIIA	tfiia	NN	NN	_	6	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	play	play	VB	VB	_	3	ccomp	_	_
16	a	a	DT	DT	_	17	det	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	Tax-mediated	tax-mediated	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Peptide	peptide	NN	NN	_	2	compound	_	_
2	vaccination	vaccination	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	lead	lead	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	enhanced	enhance	VBN	VBN	_	8	amod	_	_
7	tumor	tumor	NN	NN	_	8	compound	_	_
8	growth	growth	NN	NN	_	4	nmod	_	_
9	through	through	IN	IN	_	13	case	_	_
10	specific	specific	JJ	JJ	_	13	amod	_	_
11	T-cell	t-cell	NN	NN	_	13	compound	_	_
12	tolerance	tolerance	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	4	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Vaccination	vaccination	NN	NN	_	14	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	synthetic	synthetic	JJ	JJ	_	4	amod	_	_
4	peptides	peptide	NNS	NNS	_	1	nmod	_	_
5	representing	represent	VBG	VBG	_	4	acl	_	_
6	cytotoxic	cytotoxic	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocyte	lymphocyte	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CTL	ctl	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	epitopes	epitope	NNS	NNS	_	5	dobj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	lead	lead	VB	VB	_	0	root	_	_
15	to	to	TO	TO	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	protective	protective	JJ	JJ	_	19	amod	_	_
18	CTL-mediated	ctl-mediated	JJ	JJ	_	19	amod	_	_
19	immunity	immunity	NN	NN	_	14	nmod	_	_
20	against	against	IN	IN	_	21	case	_	_
21	tumors	tumor	NNS	NNS	_	19	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	viruses	virus	NNS	NNS	_	21	conj	_	_
24	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	32	mark	_	_
5	vaccination	vaccination	NN	NN	_	32	nsubj	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	CTL	ctl	NN	NN	_	9	compound	_	_
9	epitope	epitope	NN	NN	_	5	nmod	_	_
10	derived	derive	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	adenovirus	adenovirus	NN	NN	_	17	compound	_	_
15	type	type	NN	NN	_	17	compound	_	_
16	5	5	CD	CD	_	17	nummod	_	_
17	E1A-region	e1a-region	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Ad5E1A234-243	ad5e1a234-243	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	9	punct	_	_
22	which	which	WDT	WDT	_	24	nsubj	_	_
23	can	can	MD	MD	_	24	aux	_	_
24	serve	serve	VB	VB	_	9	acl:relcl	_	_
25	as	as	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	target	target	NN	NN	_	24	nmod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	tumor-eradicating	tumor-eradicating	JJ	JJ	_	30	amod	_	_
30	CTL	ctl	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	9	punct	_	_
32	enhances	enhance	VBZ	VBZ	_	3	ccomp	_	_
33	rather	rather	RB	RB	_	32	cc	_	_
34	than	than	IN	IN	_	33	mwe	_	_
35	inhibits	inhibit	VBZ	VBZ	_	32	conj	_	_
36	the	the	DT	DT	_	37	det	_	_
37	growth	growth	NN	NN	_	32	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	Ad5E1A-expressing	ad5e1a-expressing	JJ	JJ	_	40	amod	_	_
40	tumors	tumor	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	adverse	adverse	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	peptide	peptide	NN	NN	_	6	compound	_	_
6	vaccination	vaccination	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	rapidly	rapidly	RB	RB	_	9	advmod	_	_
9	evoked	evoke	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	required	require	VBD	VBD	_	9	conj	_	_
12	low	low	JJ	JJ	_	13	amod	_	_
13	doses	dose	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	peptide	peptide	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	10	10	CD	CD	_	18	nummod	_	_
18	micrograms	microgram	NNS	NNS	_	13	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	achieved	achieve	VBN	VBN	_	9	conj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	mode	mode	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	peptide	peptide	NN	NN	_	29	compound	_	_
29	delivery	delivery	NN	NN	_	26	nmod	_	_
30	that	that	WDT	WDT	_	31	nsubj	_	_
31	induces	induce	VBZ	VBZ	_	26	acl:relcl	_	_
32	protective	protective	JJ	JJ	_	34	amod	_	_
33	T-cell-mediated	t-cell-mediated	JJ	JJ	_	34	amod	_	_
34	immunity	immunity	NN	NN	_	31	dobj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	other	other	JJ	JJ	_	37	amod	_	_
37	models	model	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	Ad5E1A-specific	ad5e1a-specific	JJ	JJ	_	3	amod	_	_
2	CTL	ctl	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	8	nsubjpass	_	_
4	could	could	MD	MD	_	8	aux	_	_
5	no	no	RB	RB	_	6	neg	_	_
6	longer	longer	RB	RB	_	8	advmod	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	isolated	isolate	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	10	case	_	_
10	mice	mouse	NNS	NNS	_	8	nmod	_	_
11	after	after	IN	IN	_	12	case	_	_
12	injection	injection	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Ad5E1A-peptide	ad5e1a-peptide	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	indicating	indicate	VBG	VBG	_	8	xcomp	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	tolerization	tolerization	NN	NN	_	23	nsubj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	Ad5E1A-specific	ad5e1a-specific	JJ	JJ	_	22	amod	_	_
21	CTL	ctl	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	nmod	_	_
23	causes	cause	VBZ	VBZ	_	16	ccomp	_	_
24	the	the	DT	DT	_	27	det	_	_
25	enhanced	enhance	VBN	VBN	_	27	amod	_	_
26	tumor	tumor	NN	NN	_	27	compound	_	_
27	outgrowth	outgrowth	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	peptide	peptide	NN	NN	_	5	compound	_	_
5	vaccination	vaccination	NN	NN	_	14	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	immunization	immunization	NN	NN	_	14	nsubj	_	_
8	with	with	IN	IN	_	9	case	_	_
9	adenovirus	adenovirus	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	expressing	express	VBG	VBG	_	9	acl	_	_
12	Ad5E1A	ad5e1a	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	9	punct	_	_
14	induced	induce	VBD	VBD	_	0	root	_	_
15	Ad5E1A-specific	ad5e1a-specific	JJ	JJ	_	16	amod	_	_
16	immunity	immunity	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	prevented	prevent	VBD	VBD	_	14	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	outgrowth	outgrowth	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	Ad5E1A-expressing	ad5e1a-expressing	JJ	JJ	_	23	amod	_	_
23	tumors	tumor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	immunization	immunization	NN	NN	_	10	nsubj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	synthetic	synthetic	JJ	JJ	_	8	amod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	lead	lead	VB	VB	_	3	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	elimination	elimination	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	anti-tumor	anti-tumor	JJ	JJ	_	17	amod	_	_
16	CTL	ctl	NN	NN	_	17	compound	_	_
17	responses	response	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	important	important	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	design	design	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	safe	safe	JJ	JJ	_	11	amod	_	_
10	peptide-based	peptide-based	JJ	JJ	_	11	amod	_	_
11	vaccines	vaccine	NNS	NNS	_	7	nmod	_	_
12	against	against	IN	IN	_	13	case	_	_
13	tumors	tumor	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	allogeneic	allogeneic	JJ	JJ	_	17	amod	_	_
16	organ	organ	NN	NN	_	17	compound	_	_
17	transplants	transplant	NNS	NNS	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	T-cell-mediated	t-cell-mediated	JJ	JJ	_	22	amod	_	_
21	autoimmune	autoimmune	JJ	JJ	_	22	amod	_	_
22	diseases	disease	NNS	NNS	_	13	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Transgenic	transgenic	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PML/RARalpha	pml/raralpha	NN	NN	_	2	nmod	_	_
5	impairs	impair	VBZ	VBZ	_	0	root	_	_
6	myelopoiesis	myelopoiesis	NN	NN	_	5	dobj	_	_
7	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	translocation	translocation	NN	NN	_	8	nsubj	_	_
3	found	find	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	7	case	_	_
5	acute	acute	JJ	JJ	_	7	amod	_	_
6	promyelocytic	promyelocytic	JJ	JJ	_	7	amod	_	_
7	leukemia	leukemia	NN	NN	_	3	nmod	_	_
8	rearranges	rearrange	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	promyelocytic	promyelocytic	JJ	JJ	_	12	amod	_	_
11	leukemia	leukemia	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	dobj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PML	pml	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	on	on	IN	IN	_	17	case	_	_
17	chromosome	chromosome	NN	NN	_	12	nmod	_	_
18	15	15	CD	CD	_	17	nummod	_	_
19	with	with	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	retinoic	retinoic	JJ	JJ	_	24	amod	_	_
22	acid	acid	NN	NN	_	24	compound	_	_
23	receptor	receptor	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	8	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	RARalpha	raralpha	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	on	on	IN	IN	_	29	case	_	_
29	chromosome	chromosome	NN	NN	_	24	nmod	_	_
30	17	17	CD	CD	_	29	nummod	_	_
31	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	yields	yield	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	fusion	fusion	NN	NN	_	5	compound	_	_
5	transcript	transcript	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	PML/RARalpha	pml/raralpha	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	5	appos	_	_
12	with	with	IN	IN	_	16	case	_	_
13	reported	report	VBN	VBN	_	16	amod	_	_
14	dominant	dominant	JJ	JJ	_	16	amod	_	_
15	negative	negative	JJ	JJ	_	16	amod	_	_
16	functions	function	NNS	NNS	_	11	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	dep	_	_
19	absence	absence	NN	NN	_	21	dep	_	_
20	of	of	IN	IN	_	21	case	_	_
21	hormone	hormone	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	remissions	remission	NNS	NNS	_	17	nsubjpass	_	_
3	induced	induce	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	11	case	_	_
5	all-trans	all-trans	JJ	JJ	_	11	amod	_	_
6	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RA	ra	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	treatment	treatment	NN	NN	_	3	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	acute	acute	JJ	JJ	_	15	amod	_	_
14	promyelocytic	promyelocytic	JJ	JJ	_	15	amod	_	_
15	leukemia	leukemia	NN	NN	_	3	nmod	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	linked	link	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	PML/RARalpha	pml/raralpha	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	leukemic	leukemic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	14	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PML/RARalpha	pml/raralpha	NN	NN	_	5	compound	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	myelopoiesis	myelopoiesis	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	transgenic	transgenic	JJ	JJ	_	10	amod	_	_
10	mice	mouse	NNS	NNS	_	14	nsubjpass	_	_
11	expressing	express	VBG	VBG	_	10	acl	_	_
12	PML/RARalpha	pml/raralpha	NN	NN	_	11	dobj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	engineered	engineer	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	full-length	full-length	JJ	JJ	_	4	amod	_	_
3	PML/RARalpha	pml/raralpha	NN	NN	_	4	compound	_	_
4	cDNA	cdna	NN	NN	_	11	nsubjpass	_	_
5	driven	drive	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CD11b	cd11b	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	transgenic	transgenic	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Expression	expression	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	confirmed	confirm	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	bone	bone	NN	NN	_	7	compound	_	_
7	marrow	marrow	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	a	a	DT	DT	_	13	det	_	_
10	reverse	reverse	JJ	JJ	_	13	amod	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	PCR	pcr	NN	NN	_	13	compound	_	_
13	assay	assay	NN	NN	_	3	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Basal	basal	JJ	JJ	_	8	amod	_	_
2	total	total	JJ	JJ	_	8	amod	_	_
3	white	white	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	cell	cell	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	granulocyte	granulocyte	NN	NN	_	5	conj	_	_
8	counts	count	NNS	NNS	_	12	nsubj	_	_
9	did	do	VBD	VBD	_	12	aux	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	appreciably	appreciably	RB	RB	_	12	advmod	_	_
12	differ	differ	VB	VB	_	0	root	_	_
13	between	between	IN	IN	_	18	case	_	_
14	PML/RARalpha	pml/raralpha	NN	NN	_	15	nmod:npmod	_	_
15	transgenic	transgenic	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	control	control	NN	NN	_	15	conj	_	_
18	mice	mouse	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	sorter	sorter	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	CD11b+	cd11b+	JJ	JJ	_	8	amod	_	_
6	bone	bone	NN	NN	_	8	compound	_	_
7	marrow	marrow	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	similar	similar	JJ	JJ	_	12	amod	_	_
11	CD11b+	cd11b+	JJ	JJ	_	12	amod	_	_
12	populations	population	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	transgenic	transgenic	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	control	control	NN	NN	_	14	conj	_	_
17	mice	mouse	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	in	in	FW	FW	_	7	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	clonal	clonal	JJ	JJ	_	7	amod	_	_
6	growth	growth	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	17	nsubj	_	_
8	performed	perform	VBN	VBN	_	7	acl	_	_
9	on	on	IN	IN	_	11	case	_	_
10	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
11	blood	blood	NN	NN	_	8	nmod	_	_
12	from	from	IN	IN	_	16	case	_	_
13	transgenic	transgenic	JJ	JJ	_	16	amod	_	_
14	versus	versus	CC	CC	_	13	cc	_	_
15	control	control	NN	NN	_	13	conj	_	_
16	mice	mouse	NNS	NNS	_	11	nmod	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	marked	marked	JJ	JJ	_	20	amod	_	_
20	reduction	reduction	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	myeloid	myeloid	JJ	JJ	_	23	amod	_	_
23	progenitors	progenitor	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	especially	especially	RB	RB	_	27	advmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	those	those	DT	DT	_	20	nmod	_	_
28	responding	respond	VBG	VBG	_	27	acl	_	_
29	to	to	TO	TO	_	32	case	_	_
30	granulocyte/macrophage	granulocyte/macrophage	NN	NN	_	32	compound	_	_
31	colony-stimulating	colony-stimulating	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	17	punct	_	_

1	Granulocyte/macrophage	granulocyte/macrophage	NN	NN	_	3	compound	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	kit	kit	NN	NN	_	7	compound	_	_
6	ligand	ligand	NN	NN	_	7	compound	_	_
7	cotreatment	cotreatment	NN	NN	_	3	conj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	overcome	overcome	VB	VB	_	0	root	_	_
11	this	this	DT	DT	_	12	det	_	_
12	inhibition	inhibition	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	10	punct	_	_

1	Impaired	impaired	JJ	JJ	_	2	amod	_	_
2	myelopoiesis	myelopoiesis	NN	NN	_	6	nsubjpass	_	_
3	in	in	FW	FW	_	4	compound	_	_
4	vivo	vivo	FW	FW	_	2	advmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	stressing	stress	VBG	VBG	_	6	advcl	_	_
9	these	these	DT	DT	_	10	det	_	_
10	mice	mouse	NNS	NNS	_	8	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	sublethal	sublethal	JJ	JJ	_	13	amod	_	_
13	irradiation	irradiation	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Following	follow	VBG	VBG	_	2	case	_	_
2	irradiation	irradiation	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	PML/RARalpha	pml/raralpha	NN	NN	_	5	nmod:npmod	_	_
5	transgenic	transgenic	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	15	nsubj	_	_
7	,	,	,	,	_	15	punct	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	compared	compare	VBN	VBN	_	15	dep	_	_
10	with	with	IN	IN	_	11	case	_	_
11	controls	control	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	more	more	RBR	RBR	_	14	advmod	_	_
14	rapidly	rapidly	RB	RB	_	15	advmod	_	_
15	depressed	depress	VBD	VBD	_	0	root	_	_
16	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
17	white	white	JJ	JJ	_	19	amod	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	granulocyte	granulocyte	NN	NN	_	19	conj	_	_
22	counts	count	NNS	NNS	_	15	dobj	_	_
23	.	.	.	.	_	15	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	12	advcl	_	_
3	,	,	,	,	_	12	punct	_	_
4	nearly	nearly	RB	RB	_	5	advmod	_	_
5	all	all	DT	DT	_	7	nummod	_	_
6	control	control	NN	NN	_	7	compound	_	_
7	mice	mouse	NNS	NNS	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	94.4	94.4	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	survived	survive	VBD	VBD	_	0	root	_	_
13	irradiation	irradiation	NN	NN	_	12	dobj	_	_
14	,	,	,	,	_	12	punct	_	_
15	yet	yet	CC	CC	_	12	cc	_	_
16	this	this	DT	DT	_	17	det	_	_
17	irradiation	irradiation	NN	NN	_	19	nsubj	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	lethal	lethal	JJ	JJ	_	12	conj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	45.8	45.8	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	PML/RARalpha	pml/raralpha	NN	NN	_	25	nmod:npmod	_	_
25	transgenic	transgenic	JJ	JJ	_	26	amod	_	_
26	mice	mouse	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Lethality	lethality	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	associated	associate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	severe	severe	JJ	JJ	_	7	amod	_	_
7	leukopenia	leukopenia	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	transgenic	transgenic	JJ	JJ	_	12	amod	_	_
10	versus	versus	CC	CC	_	9	cc	_	_
11	control	control	NN	NN	_	9	conj	_	_
12	mice	mouse	NNS	NNS	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	3	amod	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	irradiated	irradiated	JJ	JJ	_	7	amod	_	_
6	PML/RARalpha	pml/raralpha	NN	NN	_	7	compound	_	_
7	mice	mouse	NNS	NNS	_	3	nmod	_	_
8	enhanced	enhance	VBD	VBD	_	0	root	_	_
9	granulocyte	granulocyte	NN	NN	_	10	compound	_	_
10	recovery	recovery	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	abnormal	abnormal	JJ	JJ	_	6	amod	_	_
6	myelopoiesis	myelopoiesis	NN	NN	_	14	nsubj	_	_
7	due	due	IN	IN	_	10	case	_	_
8	to	to	TO	TO	_	7	mwe	_	_
9	PML/RARalpha	pml/raralpha	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	an	a	DT	DT	_	14	det	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	event	event	NN	NN	_	3	ccomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	oncogenic	oncogenic	JJ	JJ	_	17	amod	_	_
17	transformation	transformation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Alpha	alpha	NN	NN	_	8	compound	_	_
2	4	4	CD	CD	_	8	nummod	_	_
3	beta	beta	NN	NN	_	8	compound	_	_
4	1	1	CD	CD	_	8	nummod	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	CD49d/CD29	cd49d/cd29	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	integrin	integrin	NN	NN	_	9	compound	_	_
9	costimulation	costimulation	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	enhances	enhance	VBZ	VBZ	_	0	root	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cytokine	cytokine	NN	NN	_	16	conj	_	_
19	induction	induction	NN	NN	_	16	dep	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	absence	absence	NN	NN	_	14	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	altered	altered	JJ	JJ	_	25	amod	_	_
25	sensitivity	sensitivity	NN	NN	_	22	nmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	anti-CD3	anti-cd3	NN	NN	_	28	compound	_	_
28	stimulation	stimulation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	integrin	integrin	NN	NN	_	5	compound	_	_
3	alpha	alpha	NN	NN	_	5	compound	_	_
4	4	4	CD	CD	_	5	nummod	_	_
5	beta	beta	NN	NN	_	8	nsubj	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	provide	provide	VB	VB	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	costimulus	costimulus	NN	NN	_	8	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	induce	induce	VB	VB	_	10	acl	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	secretion	secretion	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-2R	il-2r	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	conj	_	_
18	leading	lead	VBG	VBG	_	14	acl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	enhanced	enhance	VBN	VBN	_	21	amod	_	_
21	proliferation	proliferation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	purified	purify	VBN	VBN	_	28	amod	_	_
24	,	,	,	,	_	28	punct	_	_
25	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
26	blood	blood	NN	NN	_	28	compound	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Similar	similar	JJ	JJ	_	8	advmod	_	_
2	to	to	TO	TO	_	3	case	_	_
3	expression	expression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	22	mark	_	_
10	recombinant	recombinant	JJ	JJ	_	13	amod	_	_
11	vascular-cell	vascular-cell	NN	NN	_	13	compound	_	_
12	adhesion	adhesion	NN	NN	_	13	compound	_	_
13	molecule-1	molecule-1	NN	NN	_	22	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	when	when	WRB	WRB	_	16	advmod	_	_
16	co-immobilized	co-immobilize	VBN	VBN	_	22	advcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	anti-CD3	anti-cd3	NN	NN	_	19	compound	_	_
19	mAb	mab	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	enhanced	enhance	VBD	VBD	_	8	ccomp	_	_
23	the	the	DT	DT	_	24	det	_	_
24	induction	induction	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	NF-AT	nf-at	NN	NN	_	27	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	AP-1	ap-1	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	28	conj	_	_
35	as	as	IN	IN	_	36	mark	_	_
36	determined	determine	VBN	VBN	_	22	advcl	_	_
37	by	by	IN	IN	_	40	case	_	_
38	electromobility	electromobility	NN	NN	_	40	compound	_	_
39	shift	shift	NN	NN	_	40	compound	_	_
40	assays	assay	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	alpha	alpha	NN	NN	_	3	compound	_	_
2	4	4	CD	CD	_	3	nummod	_	_
3	beta	beta	NN	NN	_	5	compound	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	ligation	ligation	NN	NN	_	7	nsubj	_	_
6	alone	alone	RB	RB	_	5	advmod	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	no	no	DT	DT	_	9	neg	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	13	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	requirements	requirement	NNS	NNS	_	8	nsubj	_	_
3	for	for	IN	IN	_	4	case	_	_
4	induction	induction	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	reflected	reflect	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	requirements	requirement	NNS	NNS	_	8	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	secretion	secretion	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	multiple	multiple	JJ	JJ	_	16	amod	_	_
16	cytokines	cytokine	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	19	case	_	_
19	IL-2	il-2	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	granulocyte	granulocyte	NN	NN	_	27	compound	_	_
27	macrophage-CSF	macrophage-csf	NN	NN	_	19	conj	_	_
28	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	to	to	TO	TO	_	7	case	_	_
4	freshly	freshly	RB	RB	_	7	advmod	_	_
5	isolated	isolate	VBN	VBN	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	,	,	,	,	_	15	punct	_	_
9	in	in	FW	FW	_	12	dep	_	_
10	vitro-cultured	vitro-cultured	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	15	nsubj	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	require	require	VB	VB	_	0	root	_	_
16	costimulation	costimulation	NN	NN	_	15	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	secretion	secretion	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	response	response	NN	NN	_	15	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	anti-CD3	anti-cd3	NN	NN	_	21	nmod	_	_
24	alone	alone	RB	RB	_	23	advmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Comparison	comparison	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	dose	dose	NN	NN	_	5	compound	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	anti-CD3	anti-cd3	NN	NN	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	5	nmod	_	_
9	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	half-maximal	half-maximal	JJ	JJ	_	12	amod	_	_
12	induction	induction	NN	NN	_	16	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-2	il-2	NN	NN	_	12	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	achieved	achieve	VBN	VBN	_	9	ccomp	_	_
17	using	use	VBG	VBG	_	16	xcomp	_	_
18	the	the	DT	DT	_	20	det	_	_
19	same	same	JJ	JJ	_	20	amod	_	_
20	dose	dose	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	anti-CD3	anti-cd3	NN	NN	_	20	nmod	_	_
23	for	for	IN	IN	_	25	case	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	freshly	freshly	RB	RB	_	17	nmod	_	_
26	isolated	isolate	VBN	VBN	_	25	amod	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	cultured	culture	VBN	VBN	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	conj	_	_
31	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	dose	dose	NN	NN	_	14	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	OKT3	okt3	NN	NN	_	4	nmod	_	_
7	required	require	VBN	VBN	_	4	acl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	achieve	achieve	VB	VB	_	7	xcomp	_	_
10	half-maximal	half-maximal	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	the	the	DT	DT	_	14	det	_	_
14	same	same	JJ	JJ	_	0	root	_	_
15	using	use	VBG	VBG	_	14	xcomp	_	_
16	PMA	pma	NN	NN	_	15	dobj	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	concentrations	concentration	NNS	NNS	_	16	conj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	alpha	alpha	NN	NN	_	23	compound	_	_
22	4	4	CD	CD	_	23	nummod	_	_
23	beta	beta	NN	NN	_	25	compound	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	ligands	ligand	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	costimulation	costimulation	NN	NN	_	12	nsubj	_	_
4	by	by	IN	IN	_	9	case	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	4	4	CD	CD	_	7	nummod	_	_
7	beta	beta	NN	NN	_	9	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	ligands	ligand	NNS	NNS	_	3	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	due	due	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	stabilization	stabilization	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	interaction	interaction	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	substrate	substrate	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	rather	rather	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	alpha	alpha	NN	NN	_	9	compound	_	_
8	4	4	CD	CD	_	9	nummod	_	_
9	beta	beta	NN	NN	_	16	nsubj	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	freshly	freshly	RB	RB	_	15	advmod	_	_
13	isolated	isolate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	delivers	deliver	VBZ	VBZ	_	2	ccomp	_	_
17	a	a	DT	DT	_	19	det	_	_
18	distinct	distinct	JJ	JJ	_	19	amod	_	_
19	signal	signal	NN	NN	_	16	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	synergizes	synergize	VBZ	VBZ	_	19	acl:relcl	_	_
22	early	early	RB	RB	_	21	advmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	signals	signal	NNS	NNS	_	21	nmod	_	_
25	initiated	initiate	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	TCR/CD3	tcr/cd3	NN	NN	_	28	compound	_	_
28	ligation	ligation	NN	NN	_	25	nmod	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	induce	induce	VB	VB	_	21	xcomp	_	_
31	DNA	dna	NN	NN	_	32	compound	_	_
32	binding	binding	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	multiple	multiple	JJ	JJ	_	36	amod	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	32	nmod	_	_
37	required	require	VBN	VBN	_	32	acl	_	_
38	for	for	IN	IN	_	41	case	_	_
39	cytokine	cytokine	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	41	compound	_	_
41	induction	induction	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	Defective	defective	JJ	JJ	_	2	amod	_	_
2	transcription	transcription	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	impaired	impaired	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	c-Fos	c-fos	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	FosB	fosb	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	JunB	junb	NN	NN	_	13	conj	_	_
19	in	in	IN	IN	_	24	case	_	_
20	anergic	anergic	JJ	JJ	_	24	amod	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	helper	helper	NN	NN	_	24	compound	_	_
23	1	1	CD	CD	_	24	nummod	_	_
24	cells	cell	NNS	NNS	_	11	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	Anergic	anergic	JJ	JJ	_	4	amod	_	_
2	CD4+	cd4+	JJ	JJ	_	4	amod	_	_
3	Th	th	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubj	_	_
5	do	do	VBP	VBP	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	produce	produce	VB	VB	_	0	root	_	_
8	IL-2	il-2	NN	NN	_	7	dobj	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	challenged	challenge	VBN	VBN	_	7	advcl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	Ag-pulsed	ag-pulsed	JJ	JJ	_	14	amod	_	_
13	accessory	accessory	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	because	because	IN	IN	_	19	case	_	_
16	of	of	IN	IN	_	15	mwe	_	_
17	a	a	DT	DT	_	19	det	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	defect	defect	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	work	work	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	report	report	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	these	these	DT	DT	_	11	det	_	_
9	anergic	anergic	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	defective	defective	JJ	JJ	_	6	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	ability	ability	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	up-regulate	up-regulate	VB	VB	_	16	acl	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	transactivation	transactivation	NN	NN	_	20	conj	_	_
23	at	at	IN	IN	_	29	case	_	_
24	two	two	CD	CD	_	29	nummod	_	_
25	critical	critical	JJ	JJ	_	29	amod	_	_
26	IL-2	il-2	NN	NN	_	29	compound	_	_
27	DNA	dna	NN	NN	_	29	compound	_	_
28	enhancer	enhancer	NN	NN	_	29	compound	_	_
29	elements	element	NNS	NNS	_	20	nmod	_	_
30	:	:	:	:	_	29	punct	_	_
31	NF-AT	nf-at	NN	NN	_	29	dep	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	31	dep	_	_
35	of	of	IN	IN	_	38	case	_	_
36	activated	activate	VBN	VBN	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	34	nmod	_	_
39	;	;	:	:	_	34	punct	_	_
40	a	a	DT	DT	_	41	det	_	_
41	sequence	sequence	NN	NN	_	34	dep	_	_
42	that	that	WDT	WDT	_	43	nsubj	_	_
43	binds	bind	VBZ	VBZ	_	41	acl:relcl	_	_
44	a	a	DT	DT	_	53	det	_	_
45	heterotrimeric	heterotrimeric	JJ	JJ	_	53	amod	_	_
46	NFATp	nfatp	NN	NN	_	53	compound	_	_
47	,	,	,	,	_	46	punct	_	_
48	Fos	fos	NN	NN	_	46	conj	_	_
49	,	,	,	,	_	46	punct	_	_
50	and	and	CC	CC	_	46	cc	_	_
51	Jun	jun	NN	NN	_	46	conj	_	_
52	protein	protein	NN	NN	_	53	compound	_	_
53	complex	complex	NN	NN	_	43	dobj	_	_
54	)	)	-RRB-	-RRB-	_	34	punct	_	_
55	and	and	CC	CC	_	31	cc	_	_
56	Activator	activator	NN	NN	_	57	compound	_	_
57	Protein-1	protein-1	NN	NN	_	31	conj	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	AP-1	ap-1	NN	NN	_	57	appos	_	_
60	)	)	-RRB-	-RRB-	_	59	punct	_	_
61	(	(	-LRB-	-LRB-	_	57	punct	_	_
62	that	that	WDT	WDT	_	63	nsubj	_	_
63	binds	bind	VBZ	VBZ	_	57	acl:relcl	_	_
64	Fos	fos	NN	NN	_	67	compound	_	_
65	and	and	CC	CC	_	64	cc	_	_
66	Jun	jun	NN	NN	_	64	conj	_	_
67	heterodimers	heterodimer	NNS	NNS	_	63	dobj	_	_
68	)	)	-RRB-	-RRB-	_	57	punct	_	_
69	.	.	.	.	_	6	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	impaired	impaired	JJ	JJ	_	12	amod	_	_
11	DNA-protein	dna-protein	NN	NN	_	12	compound	_	_
12	interactions	interaction	NNS	NNS	_	18	nsubjpass	_	_
13	in	in	IN	IN	_	16	case	_	_
14	anergic	anergic	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	7	ccomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	poor	poor	JJ	JJ	_	21	amod	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	inducible	inducible	JJ	JJ	_	27	amod	_	_
25	AP-1	ap-1	NN	NN	_	27	compound	_	_
26	family	family	NN	NN	_	27	compound	_	_
27	members	member	NNS	NNS	_	21	nmod	_	_
28	c-Fos	c-fos	NN	NN	_	27	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	FosB	fosb	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	JunB	junb	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	reduced	reduce	VBN	VBN	_	5	amod	_	_
5	expression	expression	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	12	cop	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	the	the	DT	DT	_	12	det	_	_
12	result	result	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	global	global	JJ	JJ	_	17	amod	_	_
16	TCR/CD3-signaling	tcr/cd3-signaling	JJ	JJ	_	17	amod	_	_
17	defect	defect	NN	NN	_	12	nmod	_	_
18	because	because	IN	IN	_	21	mark	_	_
19	CD3	cd3	NN	NN	_	20	compound	_	_
20	cross-linking	cross-linking	NN	NN	_	21	nsubj	_	_
21	induced	induce	VBD	VBD	_	12	advcl	_	_
22	an	a	DT	DT	_	24	det	_	_
23	equivalent	equivalent	JJ	JJ	_	24	amod	_	_
24	increase	increase	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	intracellular-free	intracellular-free	JJ	JJ	_	28	amod	_	_
27	calcium	calcium	NN	NN	_	28	compound	_	_
28	ions	ion	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	as	as	RB	RB	_	24	cc	_	_
31	well	well	RB	RB	_	30	mwe	_	_
32	as	as	IN	IN	_	30	mwe	_	_
33	NFATp	nfatp	NN	NN	_	34	compound	_	_
34	dephosphorylation	dephosphorylation	NN	NN	_	24	conj	_	_
35	,	,	,	,	_	34	punct	_	_
36	translocation	translocation	NN	NN	_	34	conj	_	_
37	to	to	TO	TO	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	nucleus	nucleus	NN	NN	_	36	nmod	_	_
40	,	,	,	,	_	34	punct	_	_
41	and	and	CC	CC	_	34	cc	_	_
42	DNA	dna	NN	NN	_	43	compound	_	_
43	binding	binding	NN	NN	_	34	conj	_	_
44	in	in	IN	IN	_	50	case	_	_
45	both	both	CC	CC	_	46	cc:preconj	_	_
46	normal	normal	JJ	JJ	_	50	amod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	anergic	anergic	JJ	JJ	_	46	conj	_	_
49	T	t	NN	NN	_	50	compound	_	_
50	cells	cell	NNS	NNS	_	21	nmod	_	_
51	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	defective	defective	JJ	JJ	_	6	amod	_	_
4	IL-2	il-2	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	7	nsubj	_	_
7	appears	appear	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	20	mark	_	_
9	be	be	VB	VB	_	20	cop	_	_
10	due	due	JJ	JJ	_	20	case	_	_
11	,	,	,	,	_	20	punct	_	_
12	at	at	IN	IN	_	15	advmod	_	_
13	least	least	JJS	JJS	_	12	mwe	_	_
14	in	in	IN	IN	_	15	case	_	_
15	part	part	NN	NN	_	20	nmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	selective	selective	JJ	JJ	_	20	amod	_	_
20	block	block	NN	NN	_	7	xcomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	31	case	_	_
25	the	the	DT	DT	_	31	det	_	_
26	AP-1	ap-1	NN	NN	_	31	compound	_	_
27	Fos	fos	NN	NN	_	31	compound	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	Jun	jun	NN	NN	_	27	conj	_	_
30	family	family	NN	NN	_	31	compound	_	_
31	members	member	NNS	NNS	_	23	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	anergic	anergic	JJ	JJ	_	35	amod	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	23	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	Elevated	elevated	JJ	JJ	_	3	amod	_	_
2	cyclic	cyclic	JJ	JJ	_	3	amod	_	_
3	AMP	amp	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	6	amod	_	_
6	transcription	transcription	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	endothelial	endothelial	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	regulates	regulate	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	inducible	inducible	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	many	many	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	mechanism	mechanism	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	17	nmod	_	_
12	agents	agent	NNS	NNS	_	17	nsubj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	elevate	elevate	VBP	VBP	_	12	acl:relcl	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	cAMP	camp	NN	NN	_	14	dobj	_	_
17	inhibit	inhibit	VBP	VBP	_	9	acl:relcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	43	case	_	_
21	the	the	DT	DT	_	43	det	_	_
22	tumor	tumor	NN	NN	_	25	compound	_	_
23	necrosis	necrosis	NN	NN	_	25	compound	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	43	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	TNFalpha	tnfalpha	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	25	punct	_	_
30	tissue	tissue	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	25	conj	_	_
32	,	,	,	,	_	25	punct	_	_
33	endothelial	endothelial	JJ	JJ	_	36	amod	_	_
34	leukocyte	leukocyte	NN	NN	_	36	compound	_	_
35	adhesion	adhesion	NN	NN	_	36	compound	_	_
36	molecule-1	molecule-1	NN	NN	_	25	conj	_	_
37	,	,	,	,	_	25	punct	_	_
38	and	and	CC	CC	_	25	cc	_	_
39	vascular	vascular	JJ	JJ	_	42	amod	_	_
40	cell	cell	NN	NN	_	42	compound	_	_
41	adhesion	adhesion	NN	NN	_	42	compound	_	_
42	molecule-1	molecule-1	NN	NN	_	25	conj	_	_
43	genes	gene	NNS	NNS	_	19	nmod	_	_
44	.	.	.	.	_	6	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	forskolin	forskolin	NN	NN	_	15	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	dibutyryl	dibutyryl	NN	NN	_	5	compound	_	_
5	cAMP	camp	NN	NN	_	2	conj	_	_
6	,	,	,	,	_	2	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	elevate	elevate	VBP	VBP	_	2	acl:relcl	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	cAMP	camp	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	13	case	_	_
12	independent	independent	JJ	JJ	_	13	amod	_	_
13	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	inhibited	inhibit	VBD	VBD	_	0	root	_	_
16	TNFalpha	tnfalpha	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	tissue	tissue	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	16	conj	_	_
20	expression	expression	NN	NN	_	15	dobj	_	_
21	at	at	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	level	level	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	transcription	transcription	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Induction	induction	NN	NN	_	20	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	12	case	_	_
7	transiently	transiently	RB	RB	_	8	advmod	_	_
8	transfected	transfect	VBN	VBN	_	12	amod	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
11	THP-1	thp-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	umbilical	umbilical	JJ	JJ	_	18	amod	_	_
16	vein	vein	NN	NN	_	18	compound	_	_
17	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	12	conj	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	inhibited	inhibit	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	elevated	elevated	JJ	JJ	_	23	amod	_	_
23	cAMP	camp	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	by	by	IN	IN	_	26	case	_	_
26	overexpression	overexpression	NN	NN	_	23	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	catalytic	catalytic	JJ	JJ	_	30	amod	_	_
30	subunit	subunit	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	protein	protein	NN	NN	_	34	compound	_	_
33	kinase	kinase	NN	NN	_	34	compound	_	_
34	A	a	NN	NN	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	PKA	pka	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	20	punct	_	_

1	Elevated	elevated	JJ	JJ	_	2	amod	_	_
2	cAMP	camp	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	prevent	prevent	VB	VB	_	0	root	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	p50/p65	p50/p65	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	c-Rel/p65	c-rel/p65	NN	NN	_	9	conj	_	_
12	heterodimers	heterodimer	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	decrease	decrease	VB	VB	_	5	conj	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	translocation	translocation	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	p65	p65	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	or	or	CC	CC	_	5	cc	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	modify	modify	VB	VB	_	5	conj	_	_
23	TNFalpha-induced	tnfalpha-induced	JJ	JJ	_	24	amod	_	_
24	phosphorylation	phosphorylation	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	p65	p65	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	plasmid	plasmid	NN	NN	_	6	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	multimerized	multimerized	JJ	JJ	_	13	amod	_	_
12	kappaB	kappab	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	10	dobj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	p65	p65	NN	NN	_	6	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
18	by	by	IN	IN	_	19	case	_	_
19	agents	agent	NNS	NNS	_	17	nmod	_	_
20	that	that	IN	IN	_	21	nsubj	_	_
21	elevate	elevate	VBP	VBP	_	19	acl:relcl	_	_
22	cAMP	camp	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	by	by	IN	IN	_	25	case	_	_
25	overexpression	overexpression	NN	NN	_	19	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	catalytic	catalytic	JJ	JJ	_	29	amod	_	_
29	subunit	subunit	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	PKA	pka	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	activation	activation	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PKA	pka	NN	NN	_	5	nmod	_	_
8	reduces	reduce	VBZ	VBZ	_	3	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	set	set	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	genes	gene	NNS	NNS	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	conj	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	inhibiting	inhibit	VBG	VBG	_	8	advcl	_	_
24	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	25	amod	_	_
25	transcription	transcription	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	20	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	isoform	isoform	NN	NN	_	20	compound	_	_
6	of	of	IN	IN	_	19	case	_	_
7	the	the	DT	DT	_	19	det	_	_
8	NFAT	nfat	NN	NN	_	19	compound	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	8	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	)	)	-RRB-	-RRB-	_	11	punct	_	_
17	gene	gene	NN	NN	_	19	compound	_	_
18	family	family	NN	NN	_	19	compound	_	_
19	member	member	NN	NN	_	5	nmod	_	_
20	NFATc	nfatc	NN	NN	_	1	nmod	_	_
21	-LSB-	-lsb-	-LRB-	-LRB-	_	24	punct	_	_
22	published	publish	VBN	VBN	_	23	amod	_	_
23	erratum	erratum	NN	NN	_	24	nsubj	_	_
24	appears	appear	VBZ	VBZ	_	1	dep	_	_
25	in	in	IN	IN	_	28	case	_	_
26	J	J	NNP	NNP	_	28	compound	_	_
27	Biol	Biol	NNP	NNP	_	28	compound	_	_
28	Chem	Chem	NNP	NNP	_	24	nmod	_	_
29	1996	1996	CD	CD	_	30	nummod	_	_
30	Dec	Dec	NNP	NNP	_	28	dep	_	_
31	27	27	CD	CD	_	30	nummod	_	_
32	;	;	:	:	_	28	punct	_	_
33	271	271	CD	CD	_	35	nummod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	52	52	CD	CD	_	28	dep	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	:	:	:	:	_	28	punct	_	_
38	33705	33705	CD	CD	_	28	dep	_	_
39	-RSB-	-rsb-	-RRB-	-RRB-	_	24	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	cyclosporin	cyclosporin	NN	NN	_	7	nmod:npmod	_	_
3	A	a	NN	NN	_	7	nmod:npmod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	CsA	csa	NN	NN	_	7	nmod:npmod	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	/FK506-sensitive	/fk506-sensitive	JJ	JJ	_	9	amod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NFAT	nfat	NN	NN	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	plays	play	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	key	key	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	inducible	inducible	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	cytokine	cytokine	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	NFAT	nfat	NN	NN	_	6	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	6	aux	_	_
4	been	be	VBN	VBN	_	6	auxpass	_	_
5	recently	recently	RB	RB	_	6	advmod	_	_
6	shown	show	VBN	VBN	_	26	advcl	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	cop	_	_
9	inducible	inducible	JJ	JJ	_	6	xcomp	_	_
10	in	in	IN	IN	_	14	case	_	_
11	several	several	JJ	JJ	_	14	amod	_	_
12	non-T	non-t	JJ	JJ	_	13	amod	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	26	punct	_	_
16	the	the	DT	DT	_	20	det	_	_
17	NFAT	nfat	NN	NN	_	20	compound	_	_
18	gene	gene	NN	NN	_	20	compound	_	_
19	family	family	NN	NN	_	20	compound	_	_
20	members	member	NNS	NNS	_	26	nsubjpass	_	_
21	characterized	characterize	VBN	VBN	_	20	acl	_	_
22	to	to	TO	TO	_	23	case	_	_
23	date	date	NN	NN	_	21	nmod	_	_
24	have	have	VBP	VBP	_	26	aux	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	isolated	isolate	VBN	VBN	_	0	root	_	_
27	only	only	RB	RB	_	30	advmod	_	_
28	from	from	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	26	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RBR	RBR	_	3	advmod	_	_
3	characterize	characterize	VB	VB	_	21	ccomp	_	_
4	NFAT	nfat	NN	NN	_	5	compound	_	_
5	function	function	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	demonstrate	demonstrate	VB	VB	_	3	conj	_	_
13	cytokine	cytokine	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	specificity	specificity	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	NFAT	nfat	NN	NN	_	18	compound	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	report	report	VBP	VBP	_	0	root	_	_
22	here	here	RB	RB	_	21	advmod	_	_
23	the	the	DT	DT	_	24	det	_	_
24	isolation	isolation	NN	NN	_	21	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	characterization	characterization	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	cDNA	cdna	NN	NN	_	30	compound	_	_
30	clone	clone	NN	NN	_	24	nmod	_	_
31	from	from	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	Raji	raji	NN	NN	_	36	compound	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	line	line	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cDNA	cdna	NN	NN	_	3	compound	_	_
3	clone	clone	NN	NN	_	4	nsubj	_	_
4	encodes	encode	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	new	new	JJ	JJ	_	7	amod	_	_
7	isoform	isoform	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	NFATc.beta	nfatc.beta	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	NFAT	nfat	NN	NN	_	17	compound	_	_
14	gene	gene	NN	NN	_	17	compound	_	_
15	family	family	NN	NN	_	17	compound	_	_
16	member	member	NN	NN	_	17	compound	_	_
17	NFATc	nfatc	NN	NN	_	7	nmod	_	_
18	(	(	-LRB-	-LRB-	_	17	punct	_	_
19	designated	designate	VBN	VBN	_	17	acl	_	_
20	here	here	RB	RB	_	19	advmod	_	_
21	NFATc.alpha	nfatc.alpha	NN	NN	_	19	xcomp	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	amino	amino	NN	NN	_	4	compound	_	_
3	acid	acid	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NFATc.beta	nfatc.beta	NN	NN	_	4	nmod	_	_
7	differs	differ	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	that	that	DT	DT	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NFATc.alpha	nfatc.alpha	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	first	first	JJ	JJ	_	17	amod	_	_
15	NH2-terminal	nh2-terminal	JJ	JJ	_	17	amod	_	_
16	29	29	CD	CD	_	17	nummod	_	_
17	residues	residue	NNS	NNS	_	9	nmod	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	contains	contain	VBZ	VBZ	_	7	conj	_	_
20	an	a	DT	DT	_	22	det	_	_
21	additional	additional	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	142	142	CD	CD	_	25	nummod	_	_
25	residues	residue	NNS	NNS	_	22	nmod	_	_
26	at	at	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	COOH	cooh	NN	NN	_	29	compound	_	_
29	terminus	terminus	NN	NN	_	19	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	13	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	a	a	VBG	VBG	_	5	amod	_	_
5	probe	probe	NN	NN	_	3	dobj	_	_
6	encompassing	encompass	VBG	VBG	_	5	acl	_	_
7	a	a	DT	DT	_	9	det	_	_
8	common	common	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	isoforms	isoform	NNS	NNS	_	9	nmod	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	species	species	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	2.7	2.7	CD	CD	_	21	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	4.5	4.5	CD	CD	_	18	conj	_	_
21	kilobase	kilobase	NN	NN	_	22	dep	_	_
22	pairs	pair	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	while	while	IN	IN	_	28	mark	_	_
25	an	a	DT	DT	_	27	det	_	_
26	NFATc.beta-specific	nfatc.beta-specific	JJ	JJ	_	27	amod	_	_
27	probe	probe	NN	NN	_	28	nsubj	_	_
28	detected	detect	VBD	VBD	_	13	advcl	_	_
29	only	only	RB	RB	_	33	advmod	_	_
30	the	the	DT	DT	_	33	det	_	_
31	4.5-kilobase	4.5-kilobase	NN	NN	_	33	compound	_	_
32	pair	pair	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	28	dobj	_	_
34	which	which	WDT	WDT	_	37	nsubjpass	_	_
35	was	be	VBD	VBD	_	37	auxpass	_	_
36	preferentially	preferentially	RB	RB	_	37	advmod	_	_
37	expressed	express	VBN	VBN	_	33	acl:relcl	_	_
38	in	in	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	spleen	spleen	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFATc.beta	nfatc.beta	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	capable	capable	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	8	mark	_	_
8	activating	activate	VBG	VBG	_	6	advcl	_	_
9	an	a	DT	DT	_	13	det	_	_
10	interleukin-2	interleukin-2	NN	NN	_	13	compound	_	_
11	NFAT-driven	nfat-driven	JJ	JJ	_	13	amod	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	stimulated	stimulate	VBN	VBN	_	17	amod	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	CsA-sensitive	csa-sensitive	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	8	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	NFATc.beta	nfatc.beta	NN	NN	_	5	nsubj	_	_
4	neither	neither	CC	CC	_	5	cc:preconj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	kappa3	kappa3	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	an	a	DT	DT	_	13	det	_	_
12	NFAT-binding	nfat-binding	JJ	JJ	_	13	amod	_	_
13	site	site	NN	NN	_	9	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	tumor	tumor	NN	NN	_	20	compound	_	_
18	necrosis	necrosis	NN	NN	_	20	compound	_	_
19	factor-alpha	factor-alpha	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	9	nmod	_	_
21	nor	nor	CC	CC	_	5	cc	_	_
22	activated	activate	VBD	VBD	_	5	conj	_	_
23	the	the	DT	DT	_	27	det	_	_
24	tumor	tumor	NN	NN	_	27	compound	_	_
25	necrosis	necrosis	NN	NN	_	27	compound	_	_
26	factor-alpha	factor-alpha	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	22	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	cotransfection	cotransfection	NN	NN	_	30	compound	_	_
30	assays	assays	NN	NN	_	5	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	different	different	JJ	JJ	_	6	amod	_	_
6	members	member	NNS	NNS	_	14	nsubj	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	isoforms	isoform	NNS	NNS	_	6	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NFAT	nfat	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	family	family	NN	NN	_	6	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	regulate	regulate	VB	VB	_	3	ccomp	_	_
15	inducible	inducible	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	different	different	JJ	JJ	_	20	amod	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	monocytic	monocytic	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	12	case	_	_
7	Treponema	treponema	FW	FW	_	8	compound	_	_
8	pallidum	pallidum	FW	FW	_	12	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Borrelia	borrelia	FW	FW	_	11	compound	_	_
11	burgdorferi	burgdorferi	FW	FW	_	8	conj	_	_
12	lipoproteins	lipoprotein	NNS	NNS	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	synthetic	synthetic	JJ	JJ	_	15	amod	_	_
15	lipopeptides	lipopeptide	NNS	NNS	_	12	conj	_	_
16	proceeds	proceed	VBZ	VBZ	_	0	root	_	_
17	via	via	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	pathway	pathway	NN	NN	_	16	nmod	_	_
20	distinct	distinct	JJ	JJ	_	19	amod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	lipopolysaccharide	lipopolysaccharide	NN	NN	_	22	nmod	_	_
25	but	but	CC	CC	_	16	cc	_	_
26	involves	involve	VBZ	VBZ	_	16	conj	_	_
27	the	the	DT	DT	_	31	det	_	_
28	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
29	activator	activator	NN	NN	_	31	compound	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	26	dobj	_	_
32	.	.	.	.	_	16	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	increasing	increase	VBG	VBG	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	2	nsubj	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	lipoproteins	lipoprotein	NNS	NNS	_	16	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Treponema	treponema	FW	FW	_	9	compound	_	_
9	pallidum	pallidum	FW	FW	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Borrelia	borrelia	FW	FW	_	12	compound	_	_
12	burgdorferi	burgdorferi	FW	FW	_	9	conj	_	_
13	are	be	VBP	VBP	_	16	cop	_	_
14	key	key	JJ	JJ	_	16	amod	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	mediators	mediator	NNS	NNS	_	4	ccomp	_	_
17	during	during	IN	IN	_	18	case	_	_
18	syphilis	syphilis	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Lyme	lyme	NN	NN	_	21	compound	_	_
21	disease	disease	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	principal	principal	JJ	JJ	_	3	amod	_	_
3	objective	objective	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	present	present	JJ	JJ	_	7	amod	_	_
7	study	study	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	identify	identify	VB	VB	_	8	xcomp	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	precisely	precisely	RB	RB	_	10	advmod	_	_
13	similarities	similarity	NNS	NNS	_	10	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	divergences	divergence	NNS	NNS	_	13	conj	_	_
16	among	among	IN	IN	_	27	case	_	_
17	lipopolysaccharide	lipopolysaccharide	NN	NN	_	27	amod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	LPS	lps	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	-	-	:	:	_	17	punct	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	lipoprotein-lipopeptide-induced	lipoprotein-lipopeptide-induced	JJ	JJ	_	17	conj	_	_
24	immune	immune	JJ	JJ	_	27	amod	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	signaling	signaling	NN	NN	_	27	compound	_	_
27	events	event	NNS	NNS	_	13	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Like	like	IN	IN	_	2	case	_	_
2	LPS	lps	NN	NN	_	28	nmod	_	_
3	,	,	,	,	_	28	punct	_	_
4	purified	purify	VBN	VBN	_	8	amod	_	_
5	native	native	JJ	JJ	_	8	amod	_	_
6	B.	b.	FW	FW	_	8	compound	_	_
7	burgdorferi	burgdorferi	FW	FW	_	8	compound	_	_
8	OspA	ospa	NN	NN	_	28	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	synthetic	synthetic	JJ	JJ	_	11	amod	_	_
11	analogs	analog	NNS	NNS	_	8	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	OspA	ospa	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	OspB	ospb	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	T.	t.	FW	FW	_	21	compound	_	_
20	pallidum	pallidum	FW	FW	_	21	compound	_	_
21	lipoproteins	lipoprotein	NNS	NNS	_	13	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	Tpp47	tpp47	NN	NN	_	21	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Tpp17	tpp17	NN	NN	_	23	conj	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	all	all	DT	DT	_	8	dep	_	_
28	induced	induce	VBD	VBD	_	0	root	_	_
29	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	translocation	translocation	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	36	case	_	_
33	THP-1	thp-1	NN	NN	_	36	compound	_	_
34	human	human	JJ	JJ	_	36	amod	_	_
35	monocytoid	monocytoid	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	28	punct	_	_

1	Acylation	acylation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	OspA	ospa	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	synthetic	synthetic	JJ	JJ	_	7	amod	_	_
7	peptides	peptide	NNS	NNS	_	3	conj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	requisite	requisite	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Polymyxin	polymyxin	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	nsubj	_	_
3	abrogated	abrogate	VBD	VBD	_	0	root	_	_
4	only	only	RB	RB	_	6	advmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	response	response	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	LPS	lps	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	20	advcl	_	_
3	70Z/3-derived	70z/3-derived	JJ	JJ	_	5	amod	_	_
4	pre-B-cell	pre-b-cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	2	dobj	_	_
6	either	either	CC	CC	_	7	cc:preconj	_	_
7	lacking	lack	VBG	VBG	_	5	dep	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	expressing	express	VBG	VBG	_	7	conj	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	CD14	cd14	NN	NN	_	7	dobj	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	LPS	lps	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	20	punct	_	_
18	it	it	PRP	PRP	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	observed	observe	VBN	VBN	_	0	root	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	expression	expression	NN	NN	_	26	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	CD14	cd14	NN	NN	_	22	nmod	_	_
26	imparted	impart	VBD	VBD	_	20	ccomp	_	_
27	responsiveness	responsiveness	NN	NN	_	26	dobj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	LPS	lps	NN	NN	_	27	nmod	_	_
30	but	but	CC	CC	_	29	cc	_	_
31	not	not	RB	RB	_	33	neg	_	_
32	to	to	TO	TO	_	33	case	_	_
33	OspA	ospa	NN	NN	_	29	conj	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	spirochetal	spirochetal	JJ	JJ	_	36	amod	_	_
36	lipopeptides	lipopeptide	NNS	NNS	_	33	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	assessed	assess	VBN	VBN	_	26	parataxis	_	_
39	by	by	IN	IN	_	40	case	_	_
40	induction	induction	NN	NN	_	38	nmod	_	_
41	of	of	IN	IN	_	43	case	_	_
42	NF-kappa	nf-kappa	NN	NN	_	43	compound	_	_
43	B	b	NN	NN	_	40	nmod	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	expression	expression	NN	NN	_	40	conj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	surface	surface	NN	NN	_	49	compound	_	_
48	immunoglobulin	immunoglobulin	NN	NN	_	49	compound	_	_
49	M	m	NN	NN	_	45	nmod	_	_
50	)	)	-RRB-	-RRB-	_	38	punct	_	_
51	.	.	.	.	_	20	punct	_	_

1	Finally	finally	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	biological	biological	JJ	JJ	_	5	amod	_	_
5	relevance	relevance	NN	NN	_	23	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	observation	observation	NN	NN	_	5	nmod	_	_
9	that	that	IN	IN	_	13	mark	_	_
10	T.	t.	FW	FW	_	12	compound	_	_
11	pallidum	pallidum	FW	FW	_	12	compound	_	_
12	lipoproteins-lipopeptides	lipoproteins-lipopeptide	NNS	NNS	_	13	nsubj	_	_
13	induce	induce	VBP	VBP	_	8	ccomp	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	cytokine	cytokine	NN	NN	_	16	conj	_	_
19	production	production	NN	NN	_	13	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	supported	support	VBN	VBN	_	0	root	_	_
24	by	by	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	ability	ability	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	synthetic	synthetic	JJ	JJ	_	30	amod	_	_
30	analogs	analog	NNS	NNS	_	26	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	promote	promote	VB	VB	_	26	acl	_	_
33	human	human	JJ	JJ	_	36	amod	_	_
34	immunodeficiency	immunodeficiency	NN	NN	_	36	compound	_	_
35	virus	virus	NN	NN	_	36	compound	_	_
36	replication	replication	NN	NN	_	32	dobj	_	_
37	in	in	IN	IN	_	42	case	_	_
38	chronically	chronically	RB	RB	_	39	advmod	_	_
39	infected	infected	JJ	JJ	_	42	amod	_	_
40	U1	u1	NN	NN	_	42	compound	_	_
41	monocytoid	monocytoid	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	32	nmod	_	_
43	;	;	:	:	_	23	punct	_	_
44	these	these	DT	DT	_	45	det	_	_
45	observations	observation	NNS	NNS	_	47	nsubj	_	_
46	also	also	RB	RB	_	47	advmod	_	_
47	suggest	suggest	VBP	VBP	_	23	parataxis	_	_
48	a	a	DT	DT	_	50	det	_	_
49	potential	potential	JJ	JJ	_	50	amod	_	_
50	mechanism	mechanism	NN	NN	_	47	dobj	_	_
51	whereby	whereby	WRB	WRB	_	56	advmod	_	_
52	a	a	DT	DT	_	54	det	_	_
53	syphilitic	syphilitic	JJ	JJ	_	54	amod	_	_
54	chancre	chancre	NN	NN	_	56	nsubj	_	_
55	can	can	MD	MD	_	56	aux	_	_
56	serve	serve	VB	VB	_	50	acl:relcl	_	_
57	as	as	IN	IN	_	59	case	_	_
58	a	a	DT	DT	_	59	det	_	_
59	cofactor	cofactor	NN	NN	_	56	nmod	_	_
60	for	for	IN	IN	_	64	case	_	_
61	human	human	JJ	JJ	_	64	amod	_	_
62	immunodeficiency	immunodeficiency	NN	NN	_	64	compound	_	_
63	virus	virus	NN	NN	_	64	compound	_	_
64	transmission	transmission	NN	NN	_	59	nmod	_	_
65	.	.	.	.	_	47	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	combined	combined	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	lend	lend	VBP	VBP	_	0	root	_	_
5	additional	additional	JJ	JJ	_	6	amod	_	_
6	support	support	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	proposal	proposal	NN	NN	_	4	nmod	_	_
10	that	that	IN	IN	_	15	mark	_	_
11	spirochetal	spirochetal	JJ	JJ	_	12	amod	_	_
12	lipoproteins	lipoprotein	NNS	NNS	_	15	nsubj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	LPS	lps	NN	NN	_	12	conj	_	_
15	initiate	initiate	VBP	VBP	_	9	ccomp	_	_
16	monocyte	monocyte	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	via	via	IN	IN	_	22	case	_	_
19	different	different	JJ	JJ	_	22	amod	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	surface	surface	NN	NN	_	22	compound	_	_
22	events	event	NNS	NNS	_	15	nmod	_	_
23	but	but	CC	CC	_	15	cc	_	_
24	that	that	IN	IN	_	29	mark	_	_
25	the	the	DT	DT	_	27	det	_	_
26	signaling	signaling	NN	NN	_	27	compound	_	_
27	pathways	pathway	NNS	NNS	_	29	nsubj	_	_
28	ultimately	ultimately	RB	RB	_	29	advmod	_	_
29	converge	converge	VBP	VBP	_	15	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	produce	produce	VB	VB	_	29	xcomp	_	_
32	qualitatively	qualitatively	RB	RB	_	33	advmod	_	_
33	similar	similar	JJ	JJ	_	35	amod	_	_
34	cellular	cellular	JJ	JJ	_	35	amod	_	_
35	responses	response	NNS	NNS	_	31	dobj	_	_
36	.	.	.	.	_	4	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	differences	difference	NNS	NNS	_	0	root	_	_
4	visualized	visualize	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	10	case	_	_
6	fluorescence	fluorescence	NN	NN	_	10	compound	_	_
7	in	in	FW	FW	_	10	compound	_	_
8	situ	situ	FW	FW	_	10	compound	_	_
9	hybridization	hybridization	NN	NN	_	10	compound	_	_
10	pattern	pattern	NN	NN	_	4	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	interphase	interphase	JJ	JJ	_	13	amod	_	_
13	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	different	different	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	types	type	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Application	application	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	15	case	_	_
3	a	a	DT	DT	_	15	det	_	_
4	``	``	``	``	_	6	punct	_	_
5	formamide	formamide	NN	NN	_	6	nmod:npmod	_	_
6	free	free	JJ	JJ	_	15	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	thus	thus	RB	RB	_	6	advmod	_	_
9	``	``	``	``	_	11	punct	_	_
10	material	material	NN	NN	_	11	dep	_	_
11	preserving	preserving	NN	NN	_	6	conj	_	_
12	in	in	FW	FW	_	15	compound	_	_
13	situ	situ	FW	FW	_	15	compound	_	_
14	hybridization	hybridization	NN	NN	_	15	compound	_	_
15	technique	technique	NN	NN	_	1	nmod	_	_
16	using	use	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cDNA	cdna	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	myf3	myf3	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	revealed	reveal	VBD	VBD	_	0	root	_	_
24	the	the	DT	DT	_	26	det	_	_
25	following	following	JJ	JJ	_	26	amod	_	_
26	results	result	NNS	NNS	_	23	dobj	_	_
27	:	:	:	:	_	23	punct	_	_
28	Human	human	JJ	JJ	_	30	amod	_	_
29	rhabdomyosarcoma	rhabdomyosarcoma	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	39	nsubj	_	_
31	,	,	,	,	_	30	punct	_	_
32	characterized	characterize	VBN	VBN	_	30	acl	_	_
33	by	by	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	high	high	JJ	JJ	_	36	amod	_	_
36	expression	expression	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	myf3	myf3	NN	NN	_	36	nmod	_	_
39	show	show	VBP	VBP	_	23	parataxis	_	_
40	intensive	intensive	JJ	JJ	_	42	amod	_	_
41	hybridization	hybridization	NN	NN	_	42	compound	_	_
42	signals	signal	NNS	NNS	_	39	dobj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	their	they	PRP$	PRP$	_	45	nmod:poss	_	_
45	interphase	interphase	NN	NN	_	39	nmod	_	_
46	.	.	.	.	_	23	punct	_	_

1	RNase	rnase	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	7	nsubj	_	_
3	prior	prior	JJ	JJ	_	2	amod	_	_
4	to	to	TO	TO	_	5	case	_	_
5	hybridization	hybridization	NN	NN	_	3	nmod	_	_
6	considerably	considerably	RB	RB	_	7	advmod	_	_
7	reduces	reduce	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	size	size	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	signals	signal	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	isolated	isolate	VBN	VBN	_	5	amod	_	_
5	nuclei	nucleus	NNS	NNS	_	21	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	19	nmod	_	_
11	no	no	DT	DT	_	12	neg	_	_
12	need	need	NN	NN	_	19	nsubj	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	gene	gene	NN	NN	_	15	nmod	_	_
19	exists	exist	VBZ	VBZ	_	5	acl:relcl	_	_
20	,	,	,	,	_	5	punct	_	_
21	show	show	VBP	VBP	_	0	root	_	_
22	barely	barely	RB	RB	_	21	advmod	_	_
23	hybridization	hybridization	NN	NN	_	24	compound	_	_
24	signals	signal	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	21	punct	_	_

1	Correspondingly	correspondingly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	RNase	rnase	NN	NN	_	4	compound	_	_
4	treatment	treatment	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	hybridization	hybridization	NN	NN	_	10	compound	_	_
10	pattern	pattern	NN	NN	_	5	nmod	_	_
11	at	at	IN	IN	_	12	case	_	_
12	all	all	DT	DT	_	5	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	14	nmod	_	_
3	an	a	DT	DT	_	6	det	_	_
4	increased	increase	VBN	VBN	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	efficiency	efficiency	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	cell	cell	NN	NN	_	12	compound	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	6	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	accompanied	accompany	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	higher	higher	JJR	JJR	_	19	amod	_	_
18	hybridization	hybridization	NN	NN	_	19	compound	_	_
19	accessibility	accessibility	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	corresponding	corresponding	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	nuclei	nucleus	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Chronic	chronic	JJ	JJ	_	7	amod	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	7	compound	_	_
4	virus	virus	NN	NN	_	7	compound	_	_
5	type	type	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	infection	infection	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	disrupts	disrupt	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	autoregulatory	autoregulatory	JJ	JJ	_	14	amod	_	_
14	control	control	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	14	nmod	_	_
19	via	via	IN	IN	_	22	case	_	_
20	enhanced	enhance	VBN	VBN	_	22	amod	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	22	compound	_	_
22	degradation	degradation	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Productive	productive	JJ	JJ	_	10	amod	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	10	compound	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV-1	hiv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	infection	infection	NN	NN	_	11	nsubj	_	_
11	causes	cause	VBZ	VBZ	_	0	root	_	_
12	sustained	sustained	JJ	JJ	_	15	amod	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	chronically	chronically	RB	RB	_	18	advmod	_	_
18	infected	infect	VBN	VBN	_	20	amod	_	_
19	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	direct	direct	JJ	JJ	_	4	amod	_	_
3	temporal	temporal	JJ	JJ	_	4	amod	_	_
4	correlation	correlation	NN	NN	_	5	nsubj	_	_
5	exists	exist	VBZ	VBZ	_	0	root	_	_
6	between	between	IN	IN	_	8	case	_	_
7	HIV	hiv	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	appearance	appearance	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
14	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	myelomonoblastic	myelomonoblastic	JJ	JJ	_	19	amod	_	_
18	PLB-985	plb-985	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	16	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	constitutive	constitutive	JJ	JJ	_	10	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	HIV1-infected	hiv1-infected	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	analyzed	analyze	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	phosphorylation	phosphorylation	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	turnover	turnover	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	IkappaBalpha	ikappabalpha	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activity	activity	NN	NN	_	18	conj	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	double-stranded	double-stranded	JJ	JJ	_	32	amod	_	_
30	RNA-dependent	rna-dependent	JJ	JJ	_	32	amod	_	_
31	protein	protein	NN	NN	_	32	compound	_	_
32	kinase	kinase	NN	NN	_	26	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PKR	pkr	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	and	and	CC	CC	_	18	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	intracellular	intracellular	JJ	JJ	_	39	amod	_	_
39	levels	level	NNS	NNS	_	18	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	NF-kappaB	nf-kappab	NN	NN	_	42	compound	_	_
42	subunits	subunit	NNS	NNS	_	39	nmod	_	_
43	in	in	IN	IN	_	50	case	_	_
44	the	the	DT	DT	_	50	det	_	_
45	PLB-985	plb-985	NN	NN	_	50	compound	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	U937	u937	NN	NN	_	45	conj	_	_
48	myeloid	myeloid	JJ	JJ	_	50	amod	_	_
49	cell	cell	NN	NN	_	50	compound	_	_
50	models	model	NNS	NNS	_	18	nmod	_	_
51	.	.	.	.	_	16	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	infection	infection	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	constitutive	constitutive	JJ	JJ	_	8	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	low-level	low-level	JJ	JJ	_	5	dep	_	_
8	expression	expression	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	type	type	NN	NN	_	8	nmod	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	interferon	interferon	NN	NN	_	10	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IFN	ifn	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	at	at	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	level	level	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	PKR	pkr	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	HIV-1-infected	hiv-1-infected	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	result	result	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	low-level	low-level	JJ	JJ	_	16	amod	_	_
15	IFN	ifn	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	since	since	IN	IN	_	27	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	addition	addition	NN	NN	_	27	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	anti-IFN-alpha/beta	anti-ifn-alpha/beta	JJ	JJ	_	23	amod	_	_
23	antibody	antibody	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	cells	cell	NNS	NNS	_	20	nmod	_	_
27	decreased	decrease	VBD	VBD	_	6	advcl	_	_
28	PKR	pkr	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	analysis	analysis	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IkappaBalpha	ikappabalpha	NN	NN	_	7	compound	_	_
7	turnover	turnover	NN	NN	_	4	nmod	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	degradation	degradation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IkappaBalpha	ikappabalpha	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HIV-1-infected	hiv-1-infected	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	account	account	VB	VB	_	11	acl:relcl	_	_
20	for	for	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	constitutive	constitutive	JJ	JJ	_	25	amod	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	dramatic	dramatic	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	25	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	subunits	subunit	NNS	NNS	_	7	nmod	_	_
11	c-Rel	c-rel	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NF-kappaB2	nf-kappab2	NN	NN	_	14	compound	_	_
14	p100	p100	NN	NN	_	11	conj	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	moderate	moderate	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	3	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	NF-kappaB2	nf-kappab2	NN	NN	_	21	compound	_	_
21	p52	p52	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	RelA(p65)	rela(p65)	NN	NN	_	21	conj	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	detected	detect	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	28	case	_	_
27	HIV-1-infected	hiv-1-infected	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	whereas	whereas	IN	IN	_	25	dep	_	_
31	NF-kappaB1	nf-kappab1	NN	NN	_	33	compound	_	_
32	p105/p50	p105/p50	NN	NN	_	33	compound	_	_
33	levels	level	NNS	NNS	_	36	nsubjpass	_	_
34	were	be	VBD	VBD	_	36	auxpass	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	altered	alter	VBN	VBN	_	25	parataxis	_	_
37	relative	relative	JJ	JJ	_	40	case	_	_
38	to	to	TO	TO	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	levels	level	NNS	NNS	_	36	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	uninfected	uninfected	JJ	JJ	_	43	amod	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	myeloid	myeloid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
10	IFN	ifn	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	PKR	pkr	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	which	which	WDT	WDT	_	19	nsubj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	turn	turn	NN	NN	_	19	nmod	_	_
19	contribute	contribute	VBP	VBP	_	11	acl:relcl	_	_
20	to	to	TO	TO	_	23	case	_	_
21	enhanced	enhance	VBN	VBN	_	23	amod	_	_
22	IkappaBalpha	ikappabalpha	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	subsequent	subsequent	JJ	JJ	_	26	amod	_	_
26	degradation	degradation	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	translocation	translocation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	subunits	subunit	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	ultimately	ultimately	RB	RB	_	8	advmod	_	_
8	increase	increase	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
11	pool	pool	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-kappaB/IkappaBalpha	nf-kappab/ikappabalpha	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	autoregulatory	autoregulatory	JJ	JJ	_	17	amod	_	_
17	mechanism	mechanism	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	2	amod	_	_
2	turnover	turnover	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IkappaBalpha	ikappabalpha	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	accumulation	accumulation	NN	NN	_	2	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	contribute	contribute	VB	VB	_	0	root	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	chronically	chronically	RB	RB	_	16	advmod	_	_
16	activated	activated	JJ	JJ	_	17	amod	_	_
17	state	state	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	HIV-1-infected	hiv-1-infected	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
5	virus	virus	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	EBV-positive	ebv-positive	JJ	JJ	_	11	amod	_	_
10	gastric	gastric	JJ	JJ	_	11	amod	_	_
11	carcinoma	carcinoma	NN	NN	_	7	nmod	_	_
12	:	:	:	:	_	2	punct	_	_
13	unique	unique	JJ	JJ	_	15	amod	_	_
14	viral	viral	JJ	JJ	_	15	amod	_	_
15	latency	latency	NN	NN	_	2	dep	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	tumour	tumour	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Although	although	IN	IN	_	18	mark	_	_
2	case-oriented	case-oriented	JJ	JJ	_	3	amod	_	_
3	evidence	evidence	NN	NN	_	18	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	an	a	DT	DT	_	6	det	_	_
6	association	association	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
9	virus	virus	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	EBV	ebv	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	with	with	IN	IN	_	15	case	_	_
14	gastric	gastric	JJ	JJ	_	15	amod	_	_
15	carcinoma	carcinoma	NN	NN	_	6	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	aux	_	_
18	accumulating	accumulate	VBG	VBG	_	32	advcl	_	_
19	recently	recently	RB	RB	_	18	advmod	_	_
20	,	,	,	,	_	32	punct	_	_
21	the	the	DT	DT	_	24	det	_	_
22	interaction	interaction	NN	NN	_	24	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	s	s	NNS	NNS	_	32	nsubj	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	between	between	IN	IN	_	27	case	_	_
27	EBV	ebv	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	gastric	gastric	JJ	JJ	_	31	amod	_	_
30	epithelial	epithelial	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	conj	_	_
32	is/are	is/are	VBP	VBP	_	0	root	_	_
33	largely	largely	RB	RB	_	34	advmod	_	_
34	unknown	unknown	JJ	JJ	_	32	xcomp	_	_
35	.	.	.	.	_	32	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	seven	seven	CD	CD	_	11	nummod	_	_
8	EBV-positive	ebv-positive	JJ	JJ	_	11	amod	_	_
9	gastric	gastric	JJ	JJ	_	11	amod	_	_
10	carcinoma	carcinoma	NN	NN	_	11	compound	_	_
11	tissues	tissue	NNS	NNS	_	6	dobj	_	_
12	for	for	IN	IN	_	15	case	_	_
13	viral	viral	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	6	nmod	_	_
16	at	at	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	mRNA	mrna	NN	NN	_	19	compound	_	_
19	level	level	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	from	from	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	33	nmod	_	_
23	studies	study	NNS	NNS	_	33	nsubj	_	_
24	on	on	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	EBV	ebv	NN	NN	_	27	compound	_	_
27	oncogenicity	oncogenicity	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	human	human	JJ	JJ	_	31	amod	_	_
30	epithelial	epithelial	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	will	will	MD	MD	_	33	aux	_	_
33	benefit	benefit	VB	VB	_	6	ccomp	_	_
34	.	.	.	.	_	6	punct	_	_

1	Reverse	reverse	JJ	JJ	_	3	amod	_	_
2	transcription-PCR	transcription-pcr	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	all	all	DT	DT	_	7	advmod	_	_
7	seven	seven	CD	CD	_	10	nummod	_	_
8	EBV-positive	ebv-positive	JJ	JJ	_	10	amod	_	_
9	tumour	tumour	NN	NN	_	10	compound	_	_
10	tissues	tissue	NNS	NNS	_	12	nsubj	_	_
11	constitutively	constitutively	RB	RB	_	12	advmod	_	_
12	expressed	express	VBD	VBD	_	4	ccomp	_	_
13	EBV	ebv	NN	NN	_	15	compound	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	antigen	antigen	NN	NN	_	20	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	EBNA	ebna	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	mRNA	mrna	NN	NN	_	12	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	but	but	CC	CC	_	23	cc	_	_
23	not	not	RB	RB	_	20	cc	_	_
24	EBNA2	ebna2	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	EBNA	ebna	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	initiated	initiate	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	one	one	CD	CD	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	EBNA	ebna	NN	NN	_	11	compound	_	_
11	promoters	promoter	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	Qp	qp	NN	NN	_	7	appos	_	_
14	:	:	:	:	_	5	punct	_	_
15	by	by	IN	IN	_	16	case	_	_
16	contrast	contrast	NN	NN	_	23	nmod	_	_
17	,	,	,	,	_	23	punct	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	Cp	cp	NN	NN	_	23	nsubj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Wp	wp	NN	NN	_	19	conj	_	_
22	were	be	VBD	VBD	_	23	cop	_	_
23	silent	silent	JJ	JJ	_	5	parataxis	_	_
24	,	,	,	,	_	23	punct	_	_
25	thus	thus	RB	RB	_	26	advmod	_	_
26	resulting	result	VBG	VBG	_	23	xcomp	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	lack	lack	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	EBNA2	ebna2	NN	NN	_	32	compound	_	_
32	mRNA	mrna	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Latent	latent	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	LMP	lmp	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	2A	2a	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	three	three	CD	CD	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	seven	seven	CD	CD	_	15	nummod	_	_
15	cases	case	NNS	NNS	_	12	nmod	_	_
16	;	;	:	:	_	10	punct	_	_
17	however	however	RB	RB	_	25	advmod	_	_
18	,	,	,	,	_	25	punct	_	_
19	neither	neither	CC	CC	_	20	cc:preconj	_	_
20	LMP1	lmp1	NN	NN	_	23	compound	_	_
21	nor	nor	CC	CC	_	20	cc	_	_
22	LMP2B	lmp2b	NN	NN	_	20	conj	_	_
23	mRNA	mrna	NN	NN	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	detected	detect	VBN	VBN	_	10	parataxis	_	_
26	in	in	IN	IN	_	27	case	_	_
27	any	any	DT	DT	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	tumours	tumour	NNS	NNS	_	27	nmod	_	_
31	tested	test	VBN	VBN	_	30	acl	_	_
32	.	.	.	.	_	10	punct	_	_

1	Transcripts	transcript	NNS	NNS	_	11	nsubj	_	_
2	from	from	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	BamHI-A	bamhi-a	NN	NN	_	5	compound	_	_
5	region	region	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	viral	viral	JJ	JJ	_	9	amod	_	_
9	genome	genome	NN	NN	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	detectable	detectable	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	all	all	DT	DT	_	14	det	_	_
14	cases	case	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	BZLF1	bzlf1	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	16	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	the	the	DT	DT	_	5	det	_	_
5	product	product	NN	NN	_	2	conj	_	_
6	,	,	,	,	_	5	punct	_	_
7	an	a	DT	DT	_	9	det	_	_
8	immediate-early	immediate-early	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	5	appos	_	_
10	for	for	IN	IN	_	12	case	_	_
11	EBV	ebv	NN	NN	_	12	compound	_	_
12	replication	replication	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	expressed	express	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	18	case	_	_
18	any	any	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	them	they	PRP	PRP	_	18	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	thereby	thereby	RB	RB	_	23	advmod	_	_
23	suggesting	suggest	VBG	VBG	_	16	xcomp	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	the	the	DT	DT	_	27	det	_	_
26	tumour	tumour	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	28	nsubj	_	_
28	carried	carry	VBD	VBD	_	23	ccomp	_	_
29	EBV	ebv	NN	NN	_	30	compound	_	_
30	genomes	genome	NNS	NNS	_	28	dobj	_	_
31	in	in	IN	IN	_	35	case	_	_
32	a	a	DT	DT	_	35	det	_	_
33	tightly	tightly	RB	RB	_	34	advmod	_	_
34	latent	latent	JJ	JJ	_	35	amod	_	_
35	form	form	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	extended	extend	VBD	VBD	_	0	root	_	_
5	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
6	previous	previous	JJ	JJ	_	7	amod	_	_
7	data	datum	NNS	NNS	_	4	dobj	_	_
8	regarding	regard	VBG	VBG	_	10	case	_	_
9	EBV	ebv	NN	NN	_	10	compound	_	_
10	latency	latency	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	gastric	gastric	JJ	JJ	_	14	amod	_	_
13	carcinoma	carcinoma	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	at	at	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	level	level	NN	NN	_	10	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	have	have	VBP	VBP	_	22	aux	_	_
22	affirmed	affirm	VBN	VBN	_	4	conj	_	_
23	that	that	IN	IN	_	35	mark	_	_
24	the	the	DT	DT	_	25	det	_	_
25	programme	programme	NN	NN	_	35	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	viral	viral	JJ	JJ	_	29	amod	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	tumour	tumour	NN	NN	_	29	nmod	_	_
33	more	more	RBR	RBR	_	34	advmod	_	_
34	closely	closely	RB	RB	_	35	advmod	_	_
35	resembles	resemble	VBZ	VBZ	_	22	ccomp	_	_
36	'	'	``	``	_	37	punct	_	_
37	latency	latency	NN	NN	_	35	xcomp	_	_
38	I	i	CD	CD	_	37	nummod	_	_
39	'	'	''	''	_	37	punct	_	_
40	represented	represent	VBN	VBN	_	37	acl	_	_
41	by	by	IN	IN	_	44	case	_	_
42	Burkitt	burkitt	NN	NN	_	44	nmod:poss	_	_
43	's	's	POS	POS	_	42	case	_	_
44	lymphoma	lymphoma	NN	NN	_	40	nmod	_	_
45	than	than	IN	IN	_	47	case	_	_
46	'	'	``	``	_	47	punct	_	_
47	latency	latency	NN	NN	_	35	nmod	_	_
48	II	ii	CD	CD	_	47	nummod	_	_
49	'	'	''	''	_	47	punct	_	_
50	represented	represent	VBN	VBN	_	47	acl	_	_
51	by	by	IN	IN	_	53	case	_	_
52	the	the	DT	DT	_	53	det	_	_
53	majority	majority	NN	NN	_	50	nmod	_	_
54	of	of	IN	IN	_	56	case	_	_
55	nasopharyngeal	nasopharyngeal	JJ	JJ	_	56	amod	_	_
56	carcinomas	carcinoma	NNS	NNS	_	53	nmod	_	_
57	.	.	.	.	_	4	punct	_	_

1	Sequence-specific	sequence-specific	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	B-cell-specific	b-cell-specific	JJ	JJ	_	8	amod	_	_
7	coactivator	coactivator	NN	NN	_	8	compound	_	_
8	OCA-B	oca-b	NN	NN	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	B-cell-specific	b-cell-specific	JJ	JJ	_	2	amod	_	_
2	transcription	transcription	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	interaction	interaction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	POU	pou	NN	NN	_	14	compound	_	_
14	domain	domain	NN	NN	_	10	nmod	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	15	dobj	_	_
18	Oct-1	oct-1	NN	NN	_	17	dep	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Oct-2	oct-2	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	10	punct	_	_
22	with	with	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	B-cell-specific	b-cell-specific	JJ	JJ	_	26	amod	_	_
25	coactivator	coactivator	NN	NN	_	26	compound	_	_
26	OCA-B	oca-b	NN	NN	_	10	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	Bob-1	bob-1	NN	NN	_	26	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	OBF-1	obf-1	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	28	punct	_	_
32	and	and	CC	CC	_	26	cc	_	_
33	a	a	DT	DT	_	36	det	_	_
34	prototype	prototype	NN	NN	_	36	compound	_	_
35	octamer	octamer	NN	NN	_	36	compound	_	_
36	element	element	NN	NN	_	26	conj	_	_
37	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	OCA-B	oca-b	NN	NN	_	5	nsubj	_	_
5	binds	bind	VBZ	VBZ	_	2	ccomp	_	_
6	DNA	dna	NN	NN	_	5	dobj	_	_
7	directly	directly	RB	RB	_	5	advmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	major	major	JJ	JJ	_	11	amod	_	_
11	groove	groove	NN	NN	_	5	nmod	_	_
12	between	between	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	subdomains	subdomain	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	POU	pou	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	5	punct	_	_
21	requiring	require	VBG	VBG	_	5	advcl	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	an	a	DT	DT	_	24	det	_	_
24	A	a	NN	NN	_	21	dobj	_	_
25	at	at	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	fifth	fifth	JJ	JJ	_	28	amod	_	_
28	position	position	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	octamer	octamer	NN	NN	_	32	compound	_	_
32	element	element	NN	NN	_	28	nmod	_	_
33	and	and	CC	CC	_	24	cc	_	_
34	contact	contact	NN	NN	_	24	conj	_	_
35	with	with	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	POU	pou	NN	NN	_	38	compound	_	_
38	domain	domain	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	2	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	amino-terminal	amino-terminal	JJ	JJ	_	3	amod	_	_
3	fragment	fragment	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	OCA-B	oca-b	NN	NN	_	3	nmod	_	_
6	binds	bind	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	octamer	octamer	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	dep	_	_
12	absence	absence	NN	NN	_	16	dep	_	_
13	of	of	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	POU	pou	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	6	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	same	same	JJ	JJ	_	21	amod	_	_
20	sequence	sequence	NN	NN	_	21	compound	_	_
21	specificity	specificity	NN	NN	_	6	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Coactivator	coactivator	NN	NN	_	2	compound	_	_
2	OCA-B	oca-b	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	undergo	undergo	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	POU-dependent	pou-dependent	JJ	JJ	_	8	amod	_	_
7	conformational	conformational	JJ	JJ	_	8	amod	_	_
8	change	change	NN	NN	_	4	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	exposes	expose	VBZ	VBZ	_	8	acl:relcl	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	amino	amino	NN	NN	_	13	compound	_	_
13	terminus	terminus	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	4	punct	_	_
15	allowing	allow	VBG	VBG	_	4	advcl	_	_
16	it	it	PRP	PRP	_	15	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	recognize	recognize	VB	VB	_	15	xcomp	_	_
19	specific	specific	JJ	JJ	_	21	amod	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	sequences	sequence	NNS	NNS	_	18	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	major	major	JJ	JJ	_	25	amod	_	_
25	groove	groove	NN	NN	_	21	nmod	_	_
26	within	within	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	binding	bind	VBG	VBG	_	29	amod	_	_
29	site	site	NN	NN	_	25	nmod	_	_
30	for	for	IN	IN	_	31	case	_	_
31	Oct-1	oct-1	NN	NN	_	29	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	Oct-2	oct-2	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	recognition	recognition	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	both	both	CC	CC	_	7	cc:preconj	_	_
5	the	the	DT	DT	_	7	det	_	_
6	POU	pou	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	octamer	octamer	NN	NN	_	11	compound	_	_
11	sequence	sequence	NN	NN	_	7	conj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	OCA-B	oca-b	NN	NN	_	2	nmod	_	_
14	provides	provide	VBZ	VBZ	_	0	root	_	_
15	a	a	DT	DT	_	16	det	_	_
16	mechanism	mechanism	NN	NN	_	14	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	differential	differential	JJ	JJ	_	19	amod	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	octamer	octamer	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	19	nmod	_	_
23	containing	contain	VBG	VBG	_	22	acl	_	_
24	genes	gene	NNS	NNS	_	23	dobj	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	ubiquitous	ubiquitous	JJ	JJ	_	29	amod	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	Oct-1	oct-1	NN	NN	_	19	nmod	_	_
30	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	early	early	JJ	JJ	_	7	amod	_	_
5	growth	growth	NN	NN	_	7	compound	_	_
6	response	response	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	egr-1	egr-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	13	case	_	_
13	regulation	regulation	NN	NN	_	2	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	immediate	immediate	JJ	JJ	_	6	amod	_	_
5	early	early	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	system	system	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	critical	critical	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	determining	determine	VBG	VBG	_	14	advcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	ultimate	ultimate	JJ	JJ	_	19	amod	_	_
19	outcome	outcome	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	exposure	exposure	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	antigen	antigen	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	many	many	JJ	JJ	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	relates	relate	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	8	nmod	_	_
12	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	products	product	NNS	NNS	_	16	nsubj	_	_
16	play	play	VBP	VBP	_	11	acl:relcl	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	dictating	dictate	VBG	VBG	_	16	advcl	_	_
19	patterns	pattern	NNS	NNS	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	downstream	downstream	JJ	JJ	_	26	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	function-related	function-related	JJ	JJ	_	23	dep	_	_
26	genes	gene	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Evidence	evidence	NN	NN	_	5	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	several	several	JJ	JJ	_	4	amod	_	_
4	systems	system	NNS	NNS	_	1	nmod	_	_
5	indicates	indicate	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	immediate	immediate	JJ	JJ	_	10	amod	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	17	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	egr-1	egr-1	NN	NN	_	10	appos	_	_
13	may	may	MD	MD	_	17	aux	_	_
14	be	be	VB	VB	_	17	cop	_	_
15	of	of	IN	IN	_	17	case	_	_
16	particular	particular	JJ	JJ	_	17	amod	_	_
17	importance	importance	NN	NN	_	5	ccomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	immune	immune	JJ	JJ	_	21	amod	_	_
21	system	system	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Recently	recently	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	egr-1	egr-1	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	responsive	responsive	JJ	JJ	_	8	xcomp	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	diverse	diverse	JJ	JJ	_	17	amod	_	_
16	biochemical	biochemical	JJ	JJ	_	17	amod	_	_
17	signals	signal	NNS	NNS	_	12	nmod	_	_
18	generated	generate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	antigen	antigen	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	cytokines	cytokine	NNS	NNS	_	20	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	20	nsubjpass	_	_
6	for	for	IN	IN	_	7	case	_	_
7	egr-1	egr-1	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	determining	determine	VBG	VBG	_	5	acl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	precursors	precursor	NNS	NNS	_	12	nmod	_	_
17	has	have	VBZ	VBZ	_	20	aux	_	_
18	been	be	VBN	VBN	_	20	auxpass	_	_
19	recently	recently	RB	RB	_	20	advmod	_	_
20	elaborated	elaborate	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Finally	finally	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	potential	potential	JJ	JJ	_	4	amod	_	_
4	targets	target	NNS	NNS	_	15	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	regulation	regulation	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	zinc-finger	zinc-finger	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	encoded	encode	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	egr-1	egr-1	NN	NN	_	12	nmod	_	_
15	include	include	VBP	VBP	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	interleukin-2	interleukin-2	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	CD44	cd44	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	ICAM-1	icam-1	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	tumor	tumor	NN	NN	_	27	compound	_	_
25	necrosis	necrosis	NN	NN	_	27	compound	_	_
26	factor	factor	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	17	conj	_	_
28	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	egr-1	egr-1	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	regulation	regulation	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	6	nmod	_	_
11	will	will	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	discussed	discuss	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	context	context	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	these	these	DT	DT	_	20	det	_	_
19	recent	recent	JJ	JJ	_	20	amod	_	_
20	studies	study	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Absence	absence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	T-cell-	t-cell-	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	B-cell-specific	b-cell-specific	JJ	JJ	_	3	conj	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	3	dep	_	_
8	TCF-1	tcf-1	NN	NN	_	3	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	GATA-3	gata-3	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	BSAP	bsap	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	Hodgkin	hodgkin	NN	NN	_	18	nmod:poss	_	_
16	's	's	POS	POS	_	18	case	_	_
17	Reed-Sternberg	reed-sternberg	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	1	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	46	advcl	_	_
5	of	of	IN	IN	_	13	case	_	_
6	T	t	NN	NN	_	13	compound	_	_
7	cell	cell	NN	NN	_	13	compound	_	_
8	receptor-beta	receptor-beta	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	TcR-beta	tcr-beta	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	rearrangements	rearrangement	NNS	NNS	_	4	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	L428	l428	NN	NN	_	4	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	HDLM-1	hdlm-1	NN	NN	_	15	conj	_	_
18	cells	cell	NNS	NNS	_	15	dep	_	_
19	,	,	,	,	_	4	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	4	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	CD2	cd2	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	HDLM-1	hdlm-1	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	4	punct	_	_
28	and	and	CC	CC	_	4	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	presence	presence	NN	NN	_	4	conj	_	_
31	of	of	IN	IN	_	38	case	_	_
32	immunoglobulin	immunoglobulin	NN	NN	_	38	compound	_	_
33	heavy-chain	heavy-chain	NN	NN	_	38	compound	_	_
34	(	(	-LRB-	-LRB-	_	38	punct	_	_
35	IgH	igh	NN	NN	_	38	compound	_	_
36	)	)	-RRB-	-RRB-	_	38	punct	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	rearrangement	rearrangement	NN	NN	_	30	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	KM-H2	km-h2	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	30	nmod	_	_
42	,	,	,	,	_	46	punct	_	_
43	some	some	DT	DT	_	44	det	_	_
44	researchers	researcher	NNS	NNS	_	46	nsubj	_	_
45	have	have	VBP	VBP	_	46	aux	_	_
46	concluded	conclude	VBN	VBN	_	0	root	_	_
47	that	that	IN	IN	_	60	mark	_	_
48	these	these	DT	DT	_	51	det	_	_
49	long-term	long-term	JJ	JJ	_	51	amod	_	_
50	cell	cell	NN	NN	_	51	compound	_	_
51	lines	line	NNS	NNS	_	60	nsubj	_	_
52	derived	derive	VBN	VBN	_	51	acl	_	_
53	from	from	IN	IN	_	54	case	_	_
54	patients	patient	NNS	NNS	_	52	nmod	_	_
55	with	with	IN	IN	_	58	case	_	_
56	Hodgkin	hodgkin	NN	NN	_	58	nmod:poss	_	_
57	's	's	POS	POS	_	58	case	_	_
58	disease	disease	NN	NN	_	54	nmod	_	_
59	are	be	VBP	VBP	_	60	cop	_	_
60	lymphoid	lymphoid	JJ	JJ	_	46	ccomp	_	_
61	in	in	IN	IN	_	62	case	_	_
62	nature	nature	NN	NN	_	60	nmod	_	_
63	.	.	.	.	_	46	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	information	information	NN	NN	_	11	nsubjpass	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	7	case	_	_
5	these	these	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	has	have	VBZ	VBZ	_	11	aux	_	_
9	also	also	RB	RB	_	11	advmod	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	used	use	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	arguments	argument	NNS	NNS	_	11	nmod	_	_
14	for	for	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	origin	origin	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	H-RS	h-rs	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	tissue	tissue	NN	NN	_	20	nmod	_	_
23	despite	despite	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	frequent	frequent	JJ	JJ	_	26	amod	_	_
26	absence	absence	NN	NN	_	11	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
29	markers	marker	NNS	NNS	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Ig/TcR	ig/tcr	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	rearrangements	rearrangement	NNS	NNS	_	29	conj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	these	these	DT	DT	_	36	det	_	_
36	cells	cell	NNS	NNS	_	26	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	questioned	question	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	one	one	PRP	PRP	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	use	use	VB	VB	_	2	ccomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	limited	limited	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	markers	marker	NNS	NNS	_	9	nmod	_	_
13	or	or	CC	CC	_	9	cc	_	_
14	the	the	DT	DT	_	17	det	_	_
15	limited	limited	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	rearrangement	rearrangement	NN	NN	_	9	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	conclude	conclude	VB	VB	_	6	xcomp	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	H-RS	h-rs	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	23	nsubj	_	_
23	have	have	VBP	VBP	_	19	ccomp	_	_
24	a	a	DT	DT	_	26	det	_	_
25	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
26	origin	origin	NN	NN	_	23	dobj	_	_
27	,	,	,	,	_	6	punct	_	_
28	because	because	IN	IN	_	33	mark	_	_
29	these	these	DT	DT	_	30	det	_	_
30	markers	marker	NNS	NNS	_	33	nsubj	_	_
31	may	may	MD	MD	_	33	aux	_	_
32	be	be	VB	VB	_	33	cop	_	_
33	aberrant	aberrant	JJ	JJ	_	6	advcl	_	_
34	in	in	IN	IN	_	36	case	_	_
35	tumor	tumor	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	two	two	CD	CD	_	13	nummod	_	_
11	T-cell-specific	t-cell-specific	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TCF-1	tcf-1	NN	NN	_	13	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	GATA-3	gata-3	NN	NN	_	15	conj	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	one	one	CD	CD	_	23	nummod	_	_
21	B-cell-specific	b-cell-specific	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	13	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	BSAP	bsap	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	30	case	_	_
28	cultured	culture	VBN	VBN	_	30	amod	_	_
29	H-RS	h-rs	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	8	nmod	_	_
31	by	by	IN	IN	_	32	mark	_	_
32	using	use	VBG	VBG	_	6	advcl	_	_
33	a	a	DT	DT	_	37	det	_	_
34	gel	gel	NN	NN	_	37	compound	_	_
35	mobility	mobility	NN	NN	_	37	compound	_	_
36	shift	shift	NN	NN	_	37	compound	_	_
37	assay	assay	NN	NN	_	32	dobj	_	_
38	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	sensitivity	sensitivity	NN	NN	_	15	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	specificity	specificity	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	assay	assay	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	determination	determination	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lineage	lineage	NN	NN	_	9	nmod	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	established	establish	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	large	large	JJ	JJ	_	19	amod	_	_
19	number	number	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cultured	culture	VBN	VBN	_	22	amod	_	_
22	human	human	JJ	JJ	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	murine	murine	JJ	JJ	_	22	conj	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	22	dep	_	_
27	.	.	.	.	_	15	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	types	type	NNS	NNS	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	H-RS	h-rs	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	10	cop	_	_
9	consistently	consistently	RB	RB	_	10	advmod	_	_
10	negative	negative	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	BSAP	bsap	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	TCF-1	tcf-1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	GATA-3	gata-3	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GATA-3	gata-3	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	confirmed	confirm	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	H-RS	h-rs	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	tissues	tissue	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	an	a	DT	DT	_	17	det	_	_
14	in	in	FW	FW	_	17	amod	_	_
15	situ	situ	FW	FW	_	14	dep	_	_
16	hybridization	hybridization	NN	NN	_	17	compound	_	_
17	technique	technique	NN	NN	_	6	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Virtually	virtually	RB	RB	_	2	advmod	_	_
2	all	all	DT	DT	_	4	amod	_	_
3	B-cell	b-cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	16	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	exception	exception	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	some	some	DT	DT	_	13	det	_	_
11	myeloma	myeloma	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	positive	positive	JJ	JJ	_	0	root	_	_
17	for	for	IN	IN	_	18	case	_	_
18	BSAP	bsap	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	which	which	WDT	WDT	_	24	nsubj	_	_
21	is	be	VBZ	VBZ	_	24	cop	_	_
22	the	the	DT	DT	_	24	det	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	18	acl:relcl	_	_
25	for	for	IN	IN	_	26	case	_	_
26	promoters	promoter	NNS	NNS	_	24	nmod	_	_
27	for	for	IN	IN	_	30	case	_	_
28	several	several	JJ	JJ	_	30	amod	_	_
29	B-cell	b-cell	NN	NN	_	30	compound	_	_
30	markers	marker	NNS	NNS	_	26	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	including	include	VBG	VBG	_	33	case	_	_
33	VpreB1	vpreb1	NN	NN	_	30	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	lambda	lambda	NN	NN	_	33	conj	_	_
36	5	5	CD	CD	_	35	nummod	_	_
37	,	,	,	,	_	33	punct	_	_
38	CD19	cd19	NN	NN	_	33	conj	_	_
39	,	,	,	,	_	33	punct	_	_
40	and	and	CC	CC	_	33	cc	_	_
41	CD20	cd20	NN	NN	_	33	conj	_	_
42	.	.	.	.	_	16	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	6	nsubj	_	_
4	tested	test	VBN	VBN	_	3	acl	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	positive	positive	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	TCF-1	tcf-1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GATA-3	gata-3	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	which	which	WDT	WDT	_	16	nsubj	_	_
13	are	be	VBP	VBP	_	16	cop	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	8	acl:relcl	_	_
17	for	for	IN	IN	_	18	case	_	_
18	promoters	promoter	NNS	NNS	_	16	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	several	several	JJ	JJ	_	22	amod	_	_
21	T-cell-restricted	t-cell-restricted	JJ	JJ	_	22	amod	_	_
22	markers	marker	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	including	include	VBG	VBG	_	25	case	_	_
25	CD2	cd2	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	CD3	cd3	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	TcR	tcr	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	and	and	CC	CC	_	25	cc	_	_
32	lck	lck	NN	NN	_	25	conj	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BSAP	bsap	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	TCF-1	tcf-1	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	GATA-3	gata-3	NN	NN	_	4	conj	_	_
10	clearly	clearly	RB	RB	_	11	advmod	_	_
11	indicates	indicate	VBZ	VBZ	_	0	root	_	_
12	an	a	DT	DT	_	14	det	_	_
13	underlying	underlying	JJ	JJ	_	14	amod	_	_
14	difference	difference	NN	NN	_	11	dobj	_	_
15	between	between	IN	IN	_	17	case	_	_
16	H-RS	h-rs	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	lymphoid	lymphoid	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	11	punct	_	_

1	Translocation	translocation	NN	NN	_	2	compound	_	_
2	(3;14)(q27;q11)	(3;14)(q27;q11)	NN	NN	_	0	root	_	_
3	:	:	:	:	_	2	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	new	new	JJ	JJ	_	7	amod	_	_
6	variant	variant	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	2	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	patient	patient	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	non-Hodgkin	non-hodgkin	JJ	JJ	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	lymphoma	lymphoma	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	B-cell	b-cell	NN	NN	_	17	compound	_	_
17	type	type	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	BCL6	bcl6	NN	NN	_	20	compound	_	_
20	rearrangement	rearrangement	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	65-year-old	65-year-old	JJ	JJ	_	5	amod	_	_
5	woman	woman	NN	NN	_	2	dobj	_	_
6	with	with	IN	IN	_	9	case	_	_
7	non-Hodgkin	non-hodgkin	JJ	JJ	_	9	nmod:poss	_	_
8	's	's	POS	POS	_	7	case	_	_
9	lymphoma	lymphoma	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NHL	nhl	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	carrying	carry	VBG	VBG	_	9	acl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	t(3;14)(q27;q11)	t(3;14)(q27;q11)	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	BCL6	bcl6	NN	NN	_	18	compound	_	_
18	rearrangement	rearrangement	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	affected	affect	VBN	VBN	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	13	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	She	she	PRP	PRP	_	3	nsubj	_	_
2	had	have	VBD	VBD	_	3	aux	_	_
3	generalized	generalize	VBN	VBN	_	0	root	_	_
4	lymphadenopathy	lymphadenopathy	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	the	the	DT	DT	_	8	det	_	_
7	bone	bone	NN	NN	_	8	compound	_	_
8	marrow	marrow	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	infiltrated	infiltrate	VBN	VBN	_	3	conj	_	_
11	by	by	IN	IN	_	13	case	_	_
12	lymphoma	lymphoma	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	at	at	IN	IN	_	15	case	_	_
15	presentation	presentation	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Histological	histological	JJ	JJ	_	2	amod	_	_
2	diagnosis	diagnosis	NN	NN	_	12	nsubj	_	_
3	was	be	VBD	VBD	_	12	cop	_	_
4	``	``	``	``	_	12	punct	_	_
5	malignant	malignant	JJ	JJ	_	6	amod	_	_
6	lymphoma	lymphoma	NN	NN	_	12	compound	_	_
7	,	,	,	,	_	6	punct	_	_
8	diffuse	diffuse	JJ	JJ	_	6	appos	_	_
9	,	,	,	,	_	6	punct	_	_
10	large	large	JJ	JJ	_	11	amod	_	_
11	cell	cell	NN	NN	_	6	appos	_	_
12	type	type	NN	NN	_	0	root	_	_
13	according	accord	VBG	VBG	_	18	case	_	_
14	to	to	TO	TO	_	13	mwe	_	_
15	an	a	DT	DT	_	18	det	_	_
16	International	International	NNP	NNP	_	18	compound	_	_
17	Working	Working	NNP	NNP	_	18	compound	_	_
18	Formulation	Formulation	NNP	NNP	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Chromosome	chromosome	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	t(3;14)(q27;q11)	t(3;14)(q27;q11)	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	12	nsubj	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	new	new	JJ	JJ	_	12	amod	_	_
11	variant	variant	JJ	JJ	_	12	amod	_	_
12	translocation	translocation	NN	NN	_	5	acl:relcl	_	_
13	of	of	IN	IN	_	14	case	_	_
14	t(3;14)(q27;q32)	t(3;14)(q27;q32)	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Southern	southern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	rearrangement	rearrangement	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	BCL6	bcl6	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	JH	jh	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	TCR	tcr	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	7	conj	_	_
14	but	but	CC	CC	_	7	cc	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	of	of	IN	IN	_	18	case	_	_
17	TCR	tcr	NN	NN	_	18	compound	_	_
18	delta	delta	NN	NN	_	7	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Cosmid	cosmid	NN	NN	_	2	compound	_	_
2	probe	probe	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BCL6	bcl6	NN	NN	_	2	nmod	_	_
5	hybridized	hybridize	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	14q11	14q11	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	3q27	3q27	NN	NN	_	7	conj	_	_
10	by	by	IN	IN	_	14	case	_	_
11	fluorescence	fluorescence	NN	NN	_	14	compound	_	_
12	in	in	FW	FW	_	14	amod	_	_
13	situ	situ	FW	FW	_	12	dep	_	_
14	hybridization	hybridization	NN	NN	_	5	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	FISH	fish	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	band	band	NN	NN	_	4	compound	_	_
4	14q11	14q11	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	locus	locus	NN	NN	_	21	advcl	_	_
8	of	of	IN	IN	_	10	case	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	7	nmod	_	_
11	alpha-	alpha-	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	delta-chains	delta-chain	NNS	NNS	_	11	conj	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	TCR	tcr	NN	NN	_	16	compound	_	_
16	alpha/delta	alpha/delta	NN	NN	_	10	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	21	punct	_	_
19	lymphoma	lymphoma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	21	nsubj	_	_
21	expressed	express	VBD	VBD	_	0	root	_	_
22	B-cell	b-cell	NN	NN	_	25	compound	_	_
23	,	,	,	,	_	22	punct	_	_
24	IgGk	iggk	NN	NN	_	22	appos	_	_
25	phenotype	phenotype	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	proto-oncogene	proto-oncogene	NN	NN	_	15	nsubjpass	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	vicinity	vicinity	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	TCR	tcr	NN	NN	_	13	compound	_	_
13	alpha/delta	alpha/delta	NN	NN	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	3	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	translocation	translocation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Cross	cross	NN	NN	_	2	compound	_	_
2	talk	talk	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	5	case	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	death	death	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	cycle	cycle	NN	NN	_	9	compound	_	_
9	progression	progression	NN	NN	_	5	conj	_	_
10	:	:	:	:	_	2	punct	_	_
11	BCL-2	bcl-2	NN	NN	_	12	nsubj	_	_
12	regulates	regulate	VBZ	VBZ	_	2	dep	_	_
13	NFAT-mediated	nfat-mediated	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	12	punct	_	_

1	BCL-2-deficient	bcl-2-deficient	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	accelerated	accelerate	VBN	VBN	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	cycle	cycle	NN	NN	_	8	compound	_	_
8	progression	progression	NN	NN	_	4	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	8	conj	_	_
12	following	follow	VBG	VBG	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Increasing	increase	VBG	VBG	_	6	csubj	_	_
2	the	the	DT	DT	_	3	det	_	_
3	levels	level	NNS	NNS	_	1	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	BCL-2	bcl-2	NN	NN	_	3	nmod	_	_
6	retarded	retard	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	11	det	_	_
8	G0	g0	NN	NN	_	10	dep	_	_
9	--&gt;	--&gt;	TO	TO	_	10	dep	_	_
10	S	s	NN	NN	_	11	amod	_	_
11	transition	transition	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	6	punct	_	_
13	sustained	sustain	VBD	VBD	_	6	conj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	levels	level	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	cyclin-dependent	cyclin-dependent	JJ	JJ	_	20	amod	_	_
18	kinase	kinase	NN	NN	_	20	compound	_	_
19	inhibitor	inhibitor	NN	NN	_	20	compound	_	_
20	p27Kip1	p27kip1	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	6	punct	_	_
22	and	and	CC	CC	_	6	cc	_	_
23	repressed	repress	VBD	VBD	_	6	conj	_	_
24	postactivation	postactivation	NN	NN	_	25	compound	_	_
25	death	death	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	6	punct	_	_

1	Proximal	proximal	JJ	JJ	_	4	amod	_	_
2	signal	signal	NN	NN	_	4	compound	_	_
3	transduction	transduction	NN	NN	_	4	compound	_	_
4	events	event	NNS	NNS	_	11	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	immediate	immediate	JJ	JJ	_	9	amod	_	_
7	early	early	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	4	conj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	unaffected	unaffected	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	transcription	transcription	NN	NN	_	17	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	synthesis	synthesis	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	interleukin	interleukin	NN	NN	_	4	nmod	_	_
9	2	2	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	other	other	JJ	JJ	_	14	amod	_	_
12	delayed	delay	VBN	VBN	_	14	amod	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	cytokines	cytokine	NNS	NNS	_	8	conj	_	_
15	were	be	VBD	VBD	_	17	auxpass	_	_
16	markedly	markedly	RB	RB	_	17	advmod	_	_
17	attenuated	attenuate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	case	_	_
19	BCL-2	bcl-2	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	cysteine	cysteine	NN	NN	_	7	compound	_	_
6	protease	protease	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	12	nsubj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	blocks	block	VBZ	VBZ	_	7	acl:relcl	_	_
11	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
12	had	have	VBD	VBD	_	0	root	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	substantial	substantial	JJ	JJ	_	15	amod	_	_
15	affect	affect	NN	NN	_	12	dobj	_	_
16	upon	upon	IN	IN	_	18	case	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	InterleUkin	interleukin	NN	NN	_	3	compound	_	_
2	2	2	CD	CD	_	3	nummod	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	requires	require	VBZ	VBZ	_	0	root	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	26	nmod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	26	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NFAT	nfat	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	13	dep	_	_
17	of	of	IN	IN	_	20	case	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	)	)	-RRB-	-RRB-	_	16	punct	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	NFAT-mediated	nfat-mediated	JJ	JJ	_	24	amod	_	_
24	transactivation	transactivation	NN	NN	_	11	conj	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	impaired	impair	VBN	VBN	_	7	acl:relcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	BCL-2	bcl-2	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	select	select	JJ	JJ	_	5	amod	_	_
4	genetic	genetic	JJ	JJ	_	5	amod	_	_
5	aberrations	aberration	NNS	NNS	_	10	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	apoptotic	apoptotic	JJ	JJ	_	9	amod	_	_
9	pathway	pathway	NN	NN	_	5	nmod	_	_
10	reveal	reveal	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	autonomous	autonomous	JJ	JJ	_	14	amod	_	_
14	coregulation	coregulation	NN	NN	_	10	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	7	nsubjpass	_	_
2	mediated	mediate	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	protease	protease	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	preceded	precede	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	cleavage	cleavage	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Bcl-2	bcl-2	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Expression	expression	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	12	case	_	_
3	the	the	DT	DT	_	12	det	_	_
4	human	human	JJ	JJ	_	12	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
6	virus	virus	NN	NN	_	12	compound	_	_
7	type	type	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	12	nummod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	HIV	hiv	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	protease	protease	NN	NN	_	1	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cultured	culture	VBN	VBN	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	1	nmod	_	_
16	leads	lead	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	preceded	precede	VBN	VBN	_	16	dep	_	_
21	by	by	IN	IN	_	22	case	_	_
22	cleavage	cleavage	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	bcl-2	bcl-2	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	a	a	DT	DT	_	29	det	_	_
27	key	key	JJ	JJ	_	29	amod	_	_
28	negative	negative	JJ	JJ	_	27	dep	_	_
29	regulator	regulator	NN	NN	_	24	appos	_	_
30	of	of	IN	IN	_	32	case	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	death	death	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	level	level	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	bcl-2	bcl-2	NN	NN	_	6	nmod	_	_
9	protects	protect	VBZ	VBZ	_	0	root	_	_
10	cells	cell	NNS	NNS	_	9	dobj	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	13	advmod	_	_
13	and	and	CC	CC	_	9	advmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	protease	protease	NN	NN	_	9	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	prevents	prevent	VBZ	VBZ	_	9	conj	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	death	death	NN	NN	_	21	dobj	_	_
24	following	follow	VBG	VBG	_	23	acl	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	infection	infection	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	26	nmod	_	_
30	,	,	,	,	_	9	punct	_	_
31	while	while	IN	IN	_	32	mark	_	_
32	reducing	reduce	VBG	VBG	_	9	advcl	_	_
33	the	the	DT	DT	_	34	det	_	_
34	yields	yield	NNS	NNS	_	32	dobj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	viral	viral	JJ	JJ	_	38	amod	_	_
37	structural	structural	JJ	JJ	_	38	amod	_	_
38	proteins	protein	NNS	NNS	_	34	nmod	_	_
39	,	,	,	,	_	38	punct	_	_
40	infectivity	infectivity	NN	NN	_	38	conj	_	_
41	,	,	,	,	_	38	punct	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	tumor	tumor	NN	NN	_	46	compound	_	_
44	necrosis	necrosis	NN	NN	_	46	compound	_	_
45	factor	factor	NN	NN	_	46	compound	_	_
46	alpha	alpha	NN	NN	_	38	conj	_	_
47	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	replication	replication	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	13	nmod	_	_
10	the	the	DT	DT	_	12	det	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	protease	protease	NN	NN	_	13	nsubj	_	_
13	depletes	deplete	VBZ	VBZ	_	7	acl:relcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	infected	infected	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	bcl-2	bcl-2	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	leading	lead	VBG	VBG	_	13	advcl	_	_
21	to	to	TO	TO	_	24	case	_	_
22	oxidative	oxidative	JJ	JJ	_	24	amod	_	_
23	stress-dependent	stress-dependent	JJ	JJ	_	22	dep	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	NF	nf	NN	NN	_	28	compound	_	_
27	kappa	kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	a	a	DT	DT	_	32	det	_	_
31	cellular	cellular	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	28	appos	_	_
33	required	require	VBN	VBN	_	32	acl	_	_
34	for	for	IN	IN	_	36	case	_	_
35	HIV	hiv	NN	NN	_	36	compound	_	_
36	transcription	transcription	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	24	punct	_	_
38	and	and	CC	CC	_	24	cc	_	_
39	ultimately	ultimately	RB	RB	_	42	advmod	_	_
40	to	to	TO	TO	_	42	case	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	death	death	NN	NN	_	24	conj	_	_
43	.	.	.	.	_	2	punct	_	_

1	Purified	purify	VBN	VBN	_	2	amod	_	_
2	bcl-2	bcl-2	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	cleaved	cleave	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	protease	protease	NN	NN	_	4	nmod	_	_
8	between	between	IN	IN	_	9	case	_	_
9	phenylalanine	phenylalanine	NN	NN	_	7	nmod	_	_
10	112	112	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	alanine	alanine	NN	NN	_	9	conj	_	_
13	113	113	CD	CD	_	12	nummod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	option	option	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	HIV	hiv	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	therapy	therapy	NN	NN	_	6	nmod	_	_
11	;	;	:	:	_	3	punct	_	_
12	bcl-2	bcl-2	NN	NN	_	13	compound	_	_
13	muteins	mutein	NNS	NNS	_	3	dep	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	have	have	VBP	VBP	_	13	acl:relcl	_	_
16	noncleavable	noncleavable	JJ	JJ	_	17	amod	_	_
17	alterations	alteration	NNS	NNS	_	15	dobj	_	_
18	surrounding	surround	VBG	VBG	_	17	acl	_	_
19	the	the	DT	DT	_	23	det	_	_
20	HIV	hiv	NN	NN	_	23	compound	_	_
21	protease	protease	NN	NN	_	23	compound	_	_
22	cleavage	cleavage	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	18	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Stat	stat	NN	NN	_	4	compound	_	_
4	5b	5b	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
7	progenitors	progenitor	NNS	NNS	_	1	nmod	_	_
8	correlates	correlate	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	ability	ability	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	ErbB	erbb	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	induce	induce	VB	VB	_	11	acl	_	_
16	sustained	sustained	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	proliferation	proliferation	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	8	punct	_	_

1	Self	self	NN	NN	_	2	compound	_	_
2	renewal	renewal	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	normal	normal	JJ	JJ	_	6	amod	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	progenitors	progenitor	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	receptor	receptor	NN	NN	_	14	compound	_	_
12	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	c-ErbB	c-erbb	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	whereas	whereas	IN	IN	_	8	dep	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	receptors	receptor	NNS	NNS	_	22	nsubj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	c-Kit/Epo-R	c-kit/epo-r	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	regulate	regulate	VBP	VBP	_	8	parataxis	_	_
23	erythroid	erythroid	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	15	advcl	_	_
3	possible	possible	JJ	JJ	_	4	amod	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	that	that	WDT	WDT	_	7	nsubj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	explain	explain	VB	VB	_	4	acl:relcl	_	_
8	this	this	DT	DT	_	10	det	_	_
9	selective	selective	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	c-ErbB	c-erbb	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	analyzed	analyze	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	ability	ability	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	activate	activate	VB	VB	_	17	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	different	different	JJ	JJ	_	25	amod	_	_
25	members	member	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	Stat	stat	NN	NN	_	31	compound	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	family	family	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	15	punct	_	_

1	Ligand	ligand	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	c-ErbB	c-erbb	NN	NN	_	2	nmod	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	DNA-binding	dna-binding	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	reporter	reporter	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Stat	stat	NN	NN	_	18	compound	_	_
18	5b	5b	NN	NN	_	8	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	erythroblasts	erythroblast	NNS	NNS	_	5	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	ligand	ligand	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	c-Kit	c-kit	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	unable	unable	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	9	xcomp	_	_
12	any	any	DT	DT	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	same	same	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	erythropoietin	erythropoietin	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	nmod	_	_
6	caused	cause	VBD	VBD	_	0	root	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	DNA-binding	dna-binding	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	Stat	stat	NN	NN	_	11	compound	_	_
11	5b	5b	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	but	but	CC	CC	_	6	cc	_	_
14	failed	fail	VBD	VBD	_	6	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	14	xcomp	_	_
17	reporter	reporter	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	biochemical	biochemical	JJ	JJ	_	3	amod	_	_
3	findings	finding	NNS	NNS	_	4	nsubj	_	_
4	correlate	correlate	VBP	VBP	_	0	root	_	_
5	perfectly	perfectly	RB	RB	_	4	advmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	selective	selective	JJ	JJ	_	9	amod	_	_
9	ability	ability	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-ErbB	c-erbb	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	cause	cause	VB	VB	_	9	acl	_	_
14	sustained	sustained	JJ	JJ	_	16	amod	_	_
15	self	self	NN	NN	_	16	compound	_	_
16	renewal	renewal	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	progenitors	progenitor	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	2	compound	_	_
2	mutants	mutant	NNS	NNS	_	3	nsubj	_	_
3	render	render	VBP	VBP	_	0	root	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	6	nsubj	_	_
6	resistant	resistant	JJ	JJ	_	3	xcomp	_	_
7	to	to	TO	TO	_	9	case	_	_
8	cyclosporin	cyclosporin	NN	NN	_	9	compound	_	_
9	A	a	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	immunosuppressants	immunosuppressant	NNS	NNS	_	13	nsubjpass	_	_
3	cyclosporin	cyclosporin	NN	NN	_	4	compound	_	_
4	A	a	NN	NN	_	2	dep	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CsA	csa	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	FK506	fk506	NN	NN	_	4	conj	_	_
10	have	have	VBP	VBP	_	13	aux	_	_
11	been	be	VBN	VBN	_	13	auxpass	_	_
12	widely	widely	RB	RB	_	13	advmod	_	_
13	used	use	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	prevent	prevent	VB	VB	_	13	xcomp	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	treat	treat	VB	VB	_	15	conj	_	_
18	graft	graft	NN	NN	_	19	compound	_	_
19	rejection	rejection	NN	NN	_	15	dobj	_	_
20	after	after	IN	IN	_	25	case	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	organ	organ	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	tissue	tissue	NN	NN	_	22	conj	_	_
25	transplantations	transplantation	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	CsA	csa	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	FK506	fk506	NN	NN	_	1	conj	_	_
4	associate	associate	VBP	VBP	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	intracellular	intracellular	JJ	JJ	_	8	amod	_	_
7	binding	bind	VBG	VBG	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	i.e.	i.e.	FW	FW	_	12	advmod	_	_
11	,	,	,	,	_	12	punct	_	_
12	CsA	csa	NN	NN	_	8	dep	_	_
13	with	with	IN	IN	_	15	case	_	_
14	cyclophilin	cyclophilin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	FK506	fk506	NN	NN	_	12	conj	_	_
18	with	with	IN	IN	_	19	case	_	_
19	FKBP12	fkbp12	NN	NN	_	17	nmod	_	_
20	)	)	-RRB-	-RRB-	_	12	punct	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	form	form	VB	VB	_	4	xcomp	_	_
23	protein/drug	protein/drug	NN	NN	_	24	compound	_	_
24	complexes	complex	NNS	NNS	_	22	dobj	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	suppress	suppress	VBP	VBP	_	24	acl:relcl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	system	system	NN	NN	_	26	dobj	_	_
30	by	by	IN	IN	_	31	mark	_	_
31	preventing	prevent	VBG	VBG	_	26	advcl	_	_
32	activation	activation	NN	NN	_	31	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	in	in	IN	IN	_	40	case	_	_
37	response	response	NN	NN	_	40	dep	_	_
38	to	to	TO	TO	_	40	case	_	_
39	antigen	antigen	NN	NN	_	40	compound	_	_
40	presentation	presentation	NN	NN	_	32	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	common	common	JJ	JJ	_	3	amod	_	_
3	target	target	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CsA	csa	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	FK506	fk506	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	calcineurin	calcineurin	NN	NN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	16	det	_	_
12	Ca2+/calmodulin-regulated	ca2+/calmodulin-regulated	JJ	JJ	_	16	amod	_	_
13	,	,	,	,	_	12	punct	_	_
14	serine/threonine-specific	serine/threonine-specific	JJ	JJ	_	12	dep	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	phosphatase	phosphatase	NN	NN	_	9	appos	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	regulates	regulate	VBZ	VBZ	_	16	acl:relcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	import	import	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	NF-AT	nf-at	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	25	punct	_	_
29	required	require	VBN	VBN	_	25	acl	_	_
30	for	for	IN	IN	_	31	case	_	_
31	expression	expression	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	36	case	_	_
33	T	t	NN	NN	_	36	compound	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	activation	activation	NN	NN	_	36	compound	_	_
36	genes	gene	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	calcineurin	calcineurin	NN	NN	_	8	compound	_	_
8	mutations	mutation	NNS	NNS	_	6	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	block	block	VBP	VBP	_	8	acl:relcl	_	_
11	binding	binding	NN	NN	_	10	dobj	_	_
12	by	by	IN	IN	_	18	case	_	_
13	the	the	DT	DT	_	18	det	_	_
14	cyclophilin	cyclophilin	NN	NN	_	15	dep	_	_
15	A/CsA	a/csa	NN	NN	_	18	amod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	FKBP12/FK506	fkbp12/fk506	NN	NN	_	15	conj	_	_
18	complexes	complex	NNS	NNS	_	11	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	thereby	thereby	RB	RB	_	10	advmod	_	_
21	render	render	VBP	VBP	_	10	dep	_	_
22	yeast	yeast	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	24	nsubj	_	_
24	resistant	resistant	JJ	JJ	_	21	xcomp	_	_
25	to	to	TO	TO	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	antifungal	antifungal	JJ	JJ	_	28	amod	_	_
28	effects	effect	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	CsA	csa	NN	NN	_	28	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	FK506	fk506	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	corresponding	corresponding	JJ	JJ	_	10	amod	_	_
10	mutations	mutation	NNS	NNS	_	14	nsubj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	murine	murine	JJ	JJ	_	13	amod	_	_
13	calcineurin	calcineurin	NN	NN	_	10	nmod	_	_
14	render	render	VBP	VBP	_	6	ccomp	_	_
15	the	the	DT	DT	_	22	det	_	_
16	T	t	NN	NN	_	22	compound	_	_
17	cell	cell	NN	NN	_	22	compound	_	_
18	receptor	receptor	NN	NN	_	22	compound	_	_
19	signal	signal	NN	NN	_	22	compound	_	_
20	transduction	transduction	NN	NN	_	22	compound	_	_
21	cascade	cascade	NN	NN	_	22	compound	_	_
22	CsA	csa	NN	NN	_	23	nsubj	_	_
23	resistant	resistant	JJ	JJ	_	14	xcomp	_	_
24	in	in	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	Jurkat	jurkat	NN	NN	_	28	compound	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	10	det	_	_
5	recently	recently	RB	RB	_	6	advmod	_	_
6	determined	determine	VBN	VBN	_	10	amod	_	_
7	calcineurin	calcineurin	NN	NN	_	10	compound	_	_
8	X-ray	x-ray	NN	NN	_	10	compound	_	_
9	crystal	crystal	NN	NN	_	10	compound	_	_
10	structure	structure	NN	NN	_	3	dobj	_	_
11	,	,	,	,	_	3	punct	_	_
12	provide	provide	VBP	VBP	_	3	conj	_	_
13	evidence	evidence	NN	NN	_	12	dobj	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	calcineurin	calcineurin	NN	NN	_	20	nsubj	_	_
16	is	be	VBZ	VBZ	_	20	cop	_	_
17	the	the	DT	DT	_	20	det	_	_
18	only	only	RB	RB	_	20	advmod	_	_
19	CsA-sensitive	csa-sensitive	JJ	JJ	_	20	amod	_	_
20	component	component	NN	NN	_	13	ccomp	_	_
21	limiting	limit	VBG	VBG	_	20	acl	_	_
22	signaling	signaling	NN	NN	_	21	dobj	_	_
23	from	from	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	22	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	22	nmod	_	_
31	,	,	,	,	_	3	punct	_	_
32	and	and	CC	CC	_	3	cc	_	_
33	suggest	suggest	VBP	VBP	_	3	conj	_	_
34	a	a	DT	DT	_	35	det	_	_
35	means	means	NN	NN	_	33	dobj	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	render	render	VB	VB	_	35	acl	_	_
38	cells	cell	NNS	NNS	_	41	nsubj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	tissues	tissue	NNS	NNS	_	38	conj	_	_
41	resistant	resistant	JJ	JJ	_	37	xcomp	_	_
42	to	to	TO	TO	_	46	case	_	_
43	the	the	DT	DT	_	46	det	_	_
44	toxic	toxic	JJ	JJ	_	46	amod	_	_
45	side	side	JJ	JJ	_	46	amod	_	_
46	effects	effect	NNS	NNS	_	41	nmod	_	_
47	of	of	IN	IN	_	48	case	_	_
48	CsA	csa	NN	NN	_	46	nmod	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	FK506	fk506	NN	NN	_	48	conj	_	_
51	.	.	.	.	_	3	punct	_	_

1	Retinoid	retinoid	NN	NN	_	3	compound	_	_
2	differentiation	differentiation	NN	NN	_	3	compound	_	_
3	therapy	therapy	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	promyelocytic	promyelocytic	JJ	JJ	_	6	amod	_	_
6	leukemia	leukemia	NN	NN	_	3	nmod	_	_
7	.	.	.	.	_	3	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	promyelocytic	promyelocytic	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	APL	apl	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	type	type	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	acute	acute	JJ	JJ	_	14	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	10	nmod	_	_
15	characterized	characterize	VBN	VBN	_	10	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	morphology	morphology	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	blast	blast	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	18	punct	_	_
24	a	a	DT	DT	_	27	det	_	_
25	specific	specific	JJ	JJ	_	27	amod	_	_
26	t(15;17)	t(15;17)	NN	NN	_	27	compound	_	_
27	translocation	translocation	NN	NN	_	18	conj	_	_
28	,	,	,	,	_	18	punct	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	risks	risk	NNS	NNS	_	18	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	definite	definite	JJ	JJ	_	33	amod	_	_
33	coagulopathy	coagulopathy	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	Recently	recently	RB	RB	_	6	advmod	_	_
2	this	this	DT	DT	_	3	det	_	_
3	leukemia	leukemia	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	further	further	RB	RB	_	6	advmod	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	exquisite	exquisite	JJ	JJ	_	10	amod	_	_
10	sensitivity	sensitivity	NN	NN	_	6	nmod	_	_
11	to	to	TO	TO	_	17	case	_	_
12	all-trans	all-trans	JJ	JJ	_	14	amod	_	_
13	retinoic	retinoic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	17	nmod:poss	_	_
15	's	's	POS	POS	_	14	case	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	effect	effect	NN	NN	_	10	nmod	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	production	production	NN	NN	_	10	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	fusion	fusion	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	20	nmod	_	_
25	altering	alter	VBG	VBG	_	24	acl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	gene	gene	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	RARalpha	raralpha	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	a	a	DT	DT	_	34	det	_	_
32	novel	novel	JJ	JJ	_	34	amod	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	PML	pml	NN	NN	_	27	conj	_	_
35	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	differentiation	differentiation	NN	NN	_	4	compound	_	_
4	therapy	therapy	NN	NN	_	10	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	retinoids	retinoid	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	APL	apl	NN	NN	_	9	compound	_	_
9	patients	patient	NNS	NNS	_	4	nmod	_	_
10	follows	follow	VBZ	VBZ	_	0	root	_	_
11	strict	strict	JJ	JJ	_	12	amod	_	_
12	guidelines	guideline	NNS	NNS	_	10	dobj	_	_
13	related	related	JJ	JJ	_	12	amod	_	_
14	both	both	CC	CC	_	18	dep	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	APL	apl	NN	NN	_	18	compound	_	_
18	cell	cell	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	biodisposal	biodisposal	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	all-trans	all-trans	JJ	JJ	_	25	amod	_	_
24	retinoic	retinoic	JJ	JJ	_	25	amod	_	_
25	acid	acid	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	4	case	_	_
3	lowered	lowered	JJ	JJ	_	4	amod	_	_
4	induction	induction	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	activated	activate	VBN	VBN	_	14	amod	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
15	during	during	IN	IN	_	16	case	_	_
16	aging	aging	NN	NN	_	4	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	13	nsubjpass	_	_
3	NF	nf	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	dep	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	5	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	young	young	JJ	JJ	_	19	amod	_	_
19	individuals	individual	NNS	NNS	_	16	nmod	_	_
20	following	follow	VBG	VBG	_	21	case	_	_
21	activation	activation	NN	NN	_	13	nmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	variety	variety	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	stimuli	stimulus	NNS	NNS	_	24	nmod	_	_
27	including	include	VBG	VBG	_	28	case	_	_
28	anti-CD3	anti-cd3	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	phorbol	phorbol	NN	NN	_	32	compound	_	_
31	myristate	myristate	NN	NN	_	32	compound	_	_
32	acetate	acetate	NN	NN	_	28	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PMA	pma	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	28	punct	_	_
37	and	and	CC	CC	_	28	cc	_	_
38	tumor	tumor	NN	NN	_	40	compound	_	_
39	necrosis	necrosis	NN	NN	_	40	compound	_	_
40	factor-alpha	factor-alpha	NN	NN	_	28	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	TNF-alpha	tnf-alpha	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
7	from	from	IN	IN	_	9	case	_	_
8	older	older	JJR	JJR	_	9	amod	_	_
9	individuals	individual	NNS	NNS	_	6	nmod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	reduction	reduction	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	NF	nf	NN	NN	_	20	compound	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	response	response	NN	NN	_	16	nmod	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	same	same	JJ	JJ	_	26	amod	_	_
26	stimuli	stimulus	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	age-related	age-related	JJ	JJ	_	3	amod	_	_
3	decline	decline	NN	NN	_	13	nsubjpass	_	_
4	in	in	IN	IN	_	5	case	_	_
5	induction	induction	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF	nf	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	5	nmod	_	_
10	could	could	MD	MD	_	13	aux	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	attributed	attribute	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	alteration	alteration	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	composition	composition	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	subunits	subunit	NNS	NNS	_	18	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	p50	p50	NN	NN	_	26	nsubjpass	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	p65	p65	NN	NN	_	22	conj	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	found	find	VBN	VBN	_	13	parataxis	_	_
27	to	to	TO	TO	_	31	mark	_	_
28	be	be	VB	VB	_	31	cop	_	_
29	the	the	DT	DT	_	31	det	_	_
30	predominant	predominant	JJ	JJ	_	31	amod	_	_
31	subunits	subunit	NNS	NNS	_	26	xcomp	_	_
32	of	of	IN	IN	_	36	case	_	_
33	induced	induce	VBN	VBN	_	36	amod	_	_
34	NF	nf	NN	NN	_	36	compound	_	_
35	kappa	kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	31	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	from	from	IN	IN	_	41	case	_	_
41	young	young	JJ	JJ	_	39	nmod	_	_
42	as	as	RB	RB	_	41	cc	_	_
43	well	well	RB	RB	_	42	mwe	_	_
44	as	as	IN	IN	_	42	mwe	_	_
45	elderly	elderly	JJ	JJ	_	41	conj	_	_
46	donors	donor	NNS	NNS	_	41	dep	_	_
47	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	similar	similar	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	NF	nf	NN	NN	_	8	compound	_	_
7	kappa	kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	4	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytosols	cytosol	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	unactivated	unactivated	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	young	young	JJ	JJ	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	elderly	elderly	JJ	JJ	_	20	conj	_	_
23	donors	donor	NNS	NNS	_	20	dep	_	_
24	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
25	that	that	IN	IN	_	32	mark	_	_
26	precursor	precursor	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	32	nsubj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	NF	nf	NN	NN	_	31	compound	_	_
30	kappa	kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	27	nmod	_	_
32	remain	remain	VBP	VBP	_	24	ccomp	_	_
33	unaltered	unaltered	JJ	JJ	_	32	xcomp	_	_
34	during	during	IN	IN	_	35	case	_	_
35	aging	aging	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	an	a	DT	DT	_	7	det	_	_
6	age-associated	age-associated	JJ	JJ	_	7	amod	_	_
7	decline	decline	NN	NN	_	24	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	NF	nf	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	from	from	IN	IN	_	21	case	_	_
20	elderly	elderly	JJ	JJ	_	21	amod	_	_
21	individuals	individual	NNS	NNS	_	18	nmod	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	cop	_	_
24	attributable	attributable	JJ	JJ	_	3	ccomp	_	_
25	to	to	TO	TO	_	27	case	_	_
26	altered	altered	JJ	JJ	_	27	amod	_	_
27	regulation	regulation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	inhibitor	inhibitor	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	I	i	NN	NN	_	34	compound	_	_
33	kappa	kappa	NN	NN	_	34	compound	_	_
34	B	b	NN	NN	_	30	appos	_	_
35	,	,	,	,	_	24	punct	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	may	may	MD	MD	_	38	aux	_	_
38	play	play	VB	VB	_	24	conj	_	_
39	an	a	DT	DT	_	41	det	_	_
40	important	important	JJ	JJ	_	41	amod	_	_
41	role	role	NN	NN	_	38	dobj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	immune	immune	JJ	JJ	_	44	amod	_	_
44	dysregulation	dysregulation	NN	NN	_	38	nmod	_	_
45	accompanying	accompany	VBG	VBG	_	44	acl	_	_
46	aging	aging	NN	NN	_	45	dobj	_	_
47	.	.	.	.	_	3	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
2	viral	viral	JJ	JJ	_	3	amod	_	_
3	latency	latency	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	disrupted	disrupt	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	immediate-early	immediate-early	JJ	JJ	_	10	amod	_	_
9	BRLF1	brlf1	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	5	nmod	_	_
11	through	through	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cell-specific	cell-specific	JJ	JJ	_	14	amod	_	_
14	mechanism	mechanism	NN	NN	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	17	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	causative	causative	JJ	JJ	_	9	amod	_	_
9	agent	agent	NN	NN	_	2	appos	_	_
10	of	of	IN	IN	_	12	case	_	_
11	infectious	infectious	JJ	JJ	_	12	amod	_	_
12	mononucleosis	mononucleosis	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	herpesvirus	herpesvirus	NN	NN	_	0	root	_	_
18	associated	associate	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	22	case	_	_
20	epithelial	epithelial	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	malignancies	malignancy	NNS	NNS	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	nasopharyngeal	nasopharyngeal	JJ	JJ	_	25	amod	_	_
25	carcinoma	carcinoma	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	as	as	RB	RB	_	22	cc	_	_
28	well	well	RB	RB	_	27	mwe	_	_
29	as	as	IN	IN	_	27	mwe	_	_
30	B-cell	b-cell	NN	NN	_	31	compound	_	_
31	malignancies	malignancy	NNS	NNS	_	22	conj	_	_
32	.	.	.	.	_	17	punct	_	_

1	Understanding	understand	VBG	VBG	_	10	csubj	_	_
2	how	how	WRB	WRB	_	6	advmod	_	_
3	viral	viral	JJ	JJ	_	4	amod	_	_
4	latency	latency	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	disrupted	disrupt	VBN	VBN	_	1	ccomp	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	central	central	JJ	JJ	_	10	amod	_	_
10	issue	issue	NN	NN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	herpesvirus	herpesvirus	JJ	JJ	_	13	amod	_	_
13	biology	biology	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	Epithelial	epithelial	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	major	major	JJ	JJ	_	6	amod	_	_
6	site	site	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	lytic	lytic	JJ	JJ	_	10	amod	_	_
9	EBV	ebv	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	6	nmod	_	_
11	within	within	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	host	host	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	reactivation	reactivation	NN	NN	_	19	nsubj	_	_
19	occurs	occur	VBZ	VBZ	_	6	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	EBV-associated	ebv-associated	JJ	JJ	_	23	amod	_	_
22	nasopharyngeal	nasopharyngeal	JJ	JJ	_	23	amod	_	_
23	carcinomas	carcinoma	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	expression	expression	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	single	single	JJ	JJ	_	11	amod	_	_
9	viral	viral	JJ	JJ	_	11	amod	_	_
10	immediate-early	immediate-early	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	BZLF1	bzlf1	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	initiate	initiate	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	20	det	_	_
20	switch	switch	NN	NN	_	18	dobj	_	_
21	from	from	IN	IN	_	22	case	_	_
22	latent	latent	JJ	JJ	_	20	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	lytic	lytic	JJ	JJ	_	20	nmod	_	_
25	infection	infection	NN	NN	_	20	dep	_	_
26	in	in	IN	IN	_	28	case	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	20	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	BZLF1	bzlf1	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	therefore	therefore	RB	RB	_	8	advmod	_	_
8	thought	think	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	key	key	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	regulating	regulate	VBG	VBG	_	10	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	stringency	stringency	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	latency	latency	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	,	,	,	,	_	18	punct	_	_
6	unexpectedly	unexpectedly	RB	RB	_	18	advmod	_	_
7	,	,	,	,	_	18	punct	_	_
8	expression	expression	NN	NN	_	18	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	another	another	DT	DT	_	13	det	_	_
11	viral	viral	JJ	JJ	_	13	amod	_	_
12	immediate-early	immediate-early	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	BRLF1	brlf1	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	disrupt	disrupt	VB	VB	_	3	ccomp	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	latency	latency	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	an	a	DT	DT	_	25	det	_	_
23	epithelial	epithelial	JJ	JJ	_	24	amod	_	_
24	cell-specific	cell-specific	JJ	JJ	_	25	amod	_	_
25	fashion	fashion	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Therefore	therefore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	11	nsubj	_	_
5	leading	lead	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	7	case	_	_
7	disruption	disruption	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	EBV	ebv	NN	NN	_	10	compound	_	_
10	latency	latency	NN	NN	_	7	nmod	_	_
11	appear	appear	VBP	VBP	_	0	root	_	_
12	to	to	TO	TO	_	15	mark	_	_
13	be	be	VB	VB	_	15	cop	_	_
14	cell-type	cell-type	NN	NN	_	15	nmod:npmod	_	_
15	specific	specific	JJ	JJ	_	11	xcomp	_	_
16	.	.	.	.	_	11	punct	_	_

1	IL4	il4	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL13	il13	NN	NN	_	1	conj	_	_
4	receptors	receptor	NNS	NNS	_	5	nsubj	_	_
5	share	share	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	gamma	gamma	NN	NN	_	9	compound	_	_
8	c	c	NN	NN	_	9	compound	_	_
9	chain	chain	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	activate	activate	VBP	VBP	_	5	conj	_	_
12	STAT6	stat6	NN	NN	_	17	compound	_	_
13	,	,	,	,	_	12	punct	_	_
14	STAT3	stat3	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	STAT5	stat5	NN	NN	_	12	conj	_	_
17	proteins	protein	NNS	NNS	_	11	dobj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	normal	normal	JJ	JJ	_	22	amod	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	5	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	IL13	il13	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	same	same	JJ	JJ	_	6	amod	_	_
5	biological	biological	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	2	dobj	_	_
7	as	as	IN	IN	_	8	case	_	_
8	IL4	il4	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	as	as	IN	IN	_	8	case	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL4R	il4r	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	18	advcl	_	_
9	,	,	,	,	_	18	punct	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	IL4R	il4r	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	18	nsubj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL2R	il2r	NN	NN	_	16	compound	_	_
15	gamma	gamma	NN	NN	_	16	compound	_	_
16	c	c	NN	NN	_	12	conj	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	components	component	NNS	NNS	_	2	ccomp	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	IL13R	il13r	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	both	both	DT	DT	_	25	det	_	_
25	cytokines	cytokine	NNS	NNS	_	26	nsubj	_	_
26	induced	induce	VBD	VBD	_	18	conj	_	_
27	STAT6	stat6	NN	NN	_	32	compound	_	_
28	,	,	,	,	_	27	punct	_	_
29	STAT3	stat3	NN	NN	_	27	conj	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	STAT5	stat5	NN	NN	_	27	conj	_	_
32	activation	activation	NN	NN	_	26	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	spite	spite	NN	NN	_	7	dep	_	_
3	of	of	IN	IN	_	7	case	_	_
4	this	this	DT	DT	_	7	det	_	_
5	similar	similar	JJ	JJ	_	7	amod	_	_
6	downstream	downstream	JJ	JJ	_	7	amod	_	_
7	signalling	signalling	NN	NN	_	12	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	IL4	il4	NN	NN	_	12	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL13	il13	NN	NN	_	9	conj	_	_
12	used	use	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	set	set	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Janus	janus	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	15	nmod	_	_
19	:	:	:	:	_	12	punct	_	_
20	IL13	il13	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	unable	unable	JJ	JJ	_	12	parataxis	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	activate	activate	VB	VB	_	22	xcomp	_	_
25	JAK1	jak1	NN	NN	_	24	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	JAK3	jak3	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	22	punct	_	_

1	Attenuated	attenuate	VBN	VBN	_	2	amod	_	_
2	function	function	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	variant	variant	JJ	JJ	_	6	amod	_	_
6	form	form	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	helix-loop-helix	helix-loop-helix	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	Id-3	id-3	NN	NN	_	6	appos	_	_
13	,	,	,	,	_	6	punct	_	_
14	generated	generate	VBN	VBN	_	6	acl	_	_
15	by	by	IN	IN	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	alternative	alternative	JJ	JJ	_	19	amod	_	_
18	splicing	splicing	NN	NN	_	19	compound	_	_
19	mechanism	mechanism	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Id	id	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	helix-loop-helix	helix-loop-helix	JJ	JJ	_	6	amod	_	_
6	proteins	protein	NNS	NNS	_	3	nmod	_	_
7	function	function	VBP	VBP	_	0	root	_	_
8	as	as	IN	IN	_	10	case	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	regulators	regulator	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	17	amod	_	_
12	DNA	dna	NN	NN	_	13	dep	_	_
13	binding	binding	NN	NN	_	17	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	basic	basic	JJ	JJ	_	16	amod	_	_
16	helix-loop-helix	helix-loop-helix	JJ	JJ	_	13	dep	_	_
17	proteins	protein	NNS	NNS	_	10	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	regulation	regulation	NN	NN	_	7	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cell	cell	NN	NN	_	20	nmod	_	_
23	growth	growth	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	differentiation	differentiation	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	identification	identification	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	17	17	CD	CD	_	10	compound	_	_
10	kDa	kda	NN	NN	_	11	amod	_	_
11	variant	variant	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	14	14	CD	CD	_	15	compound	_	_
15	kDa	kda	NN	NN	_	17	amod	_	_
16	Id-3	id-3	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	11	nmod	_	_
18	termed	term	VBN	VBN	_	11	acl	_	_
19	Id-3L	id-3l	NN	NN	_	18	xcomp	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	long	long	JJ	JJ	_	22	amod	_	_
22	version	version	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	possesses	possess	VBZ	VBZ	_	11	acl:relcl	_	_
26	a	a	DT	DT	_	31	det	_	_
27	unique	unique	JJ	JJ	_	31	amod	_	_
28	60	60	CD	CD	_	31	nummod	_	_
29	amino	amino	NN	NN	_	31	compound	_	_
30	acid	acid	NN	NN	_	31	compound	_	_
31	carboxy-terminus	carboxy-terminus	NN	NN	_	25	dobj	_	_
32	generated	generate	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	34	case	_	_
34	read	read	VBN	VBN	_	32	nmod	_	_
35	through	through	IN	IN	_	34	amod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	'	'	``	``	_	40	punct	_	_
39	coding	code	VBG	VBG	_	40	amod	_	_
40	intron	intron	NN	NN	_	34	nmod	_	_
41	'	'	''	''	_	40	punct	_	_
42	and	and	CC	CC	_	34	cc	_	_
43	alternative	alternative	JJ	JJ	_	44	amod	_	_
44	splicing	splicing	NN	NN	_	34	conj	_	_
45	.	.	.	.	_	2	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	minor	minor	JJ	JJ	_	11	amod	_	_
8	1.1	1.1	CD	CD	_	9	compound	_	_
9	kb	kb	NN	NN	_	11	amod	_	_
10	Id-3L	id-3l	NN	NN	_	11	compound	_	_
11	transcript	transcript	NN	NN	_	4	nmod	_	_
12	together	together	RB	RB	_	11	cc	_	_
13	with	with	IN	IN	_	12	dep	_	_
14	the	the	DT	DT	_	19	det	_	_
15	predominant	predominant	JJ	JJ	_	19	amod	_	_
16	0.95	0.95	CD	CD	_	17	compound	_	_
17	kb	kb	NN	NN	_	19	amod	_	_
18	Id-3	id-3	NN	NN	_	19	compound	_	_
19	transcript	transcript	NN	NN	_	11	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	majority	majority	NN	NN	_	4	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	adult	adult	JJ	JJ	_	26	amod	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	tissues	tissue	NNS	NNS	_	22	nmod	_	_
27	analysed	analyse	VBN	VBN	_	26	acl	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	variant	variant	JJ	JJ	_	4	amod	_	_
3	Id-3L	id-3l	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	functionally	functionally	RB	RB	_	7	advmod	_	_
7	distinguishable	distinguishable	JJ	JJ	_	0	root	_	_
8	from	from	IN	IN	_	10	case	_	_
9	conventional	conventional	JJ	JJ	_	10	amod	_	_
10	Id-3	id-3	NN	NN	_	7	nmod	_	_
11	since	since	IN	IN	_	23	mark	_	_
12	in	in	IN	IN	_	18	case	_	_
13	in	in	FW	FW	_	18	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	DNA	dna	NN	NN	_	18	compound	_	_
16	mobility	mobility	NN	NN	_	18	compound	_	_
17	shift	shift	NN	NN	_	18	compound	_	_
18	assays	assay	NNS	NNS	_	23	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	it	it	PRP	PRP	_	23	nsubj	_	_
21	was	be	VBD	VBD	_	23	cop	_	_
22	greatly	greatly	RB	RB	_	23	advmod	_	_
23	impaired	impaired	JJ	JJ	_	7	advcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
26	ability	ability	NN	NN	_	23	nmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	abrogate	abrogate	VB	VB	_	26	acl	_	_
29	binding	binding	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	basic	basic	JJ	JJ	_	33	amod	_	_
33	helix-loop-helix	helix-loop-helix	JJ	JJ	_	34	amod	_	_
34	protein	protein	NN	NN	_	29	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	E47	e47	NN	NN	_	34	appos	_	_
37	,	,	,	,	_	34	punct	_	_
38	to	to	TO	TO	_	43	case	_	_
39	an	a	DT	DT	_	43	det	_	_
40	E	e	NN	NN	_	43	compound	_	_
41	box	box	NN	NN	_	43	compound	_	_
42	recognition	recognition	NN	NN	_	43	compound	_	_
43	sequence	sequence	NN	NN	_	29	nmod	_	_
44	.	.	.	.	_	7	punct	_	_

1	Multifactor	multifactor	JJ	JJ	_	4	amod	_	_
2	cis-dominant	cis-dominant	JJ	JJ	_	4	amod	_	_
3	negative	negative	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-2	il-2	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	anergized	anergize	VBN	VBN	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	16	nsubjpass	_	_
4	underlying	underlie	VBG	VBG	_	3	acl	_	_
5	IL-2	il-2	NN	NN	_	7	compound	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	blockade	blockade	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	anergic	anergic	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	clones	clone	NNS	NNS	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	16	auxpass	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	fully	fully	RB	RB	_	16	advmod	_	_
16	understood	understand	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	12	advcl	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	an	a	DT	DT	_	8	det	_	_
5	active	active	JJ	JJ	_	8	amod	_	_
6	negative	negative	JJ	JJ	_	7	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	process	process	NN	NN	_	9	nsubj	_	_
9	occurs	occur	VBZ	VBZ	_	2	ccomp	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	created	create	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	construct	construct	NN	NN	_	12	dobj	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	as	as	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	enhancer	enhancer	NN	NN	_	16	nmod	_	_
20	four	four	CD	CD	_	21	nummod	_	_
21	copies	copy	NNS	NNS	_	16	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	NF-AT	nf-at	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	one	one	CD	CD	_	28	nummod	_	_
28	copy	copy	NN	NN	_	21	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	octamer	octamer	NN	NN	_	32	compound	_	_
32	site	site	NN	NN	_	28	nmod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	4X	4x	NN	NN	_	35	compound	_	_
35	NF-AT-Oct	nf-at-oct	NN	NN	_	21	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	construct	construct	NN	NN	_	6	nsubjpass	_	_
3	was	be	VBD	VBD	_	6	auxpass	_	_
4	only	only	RB	RB	_	5	advmod	_	_
5	slightly	slightly	RB	RB	_	6	advmod	_	_
6	reduced	reduce	VBN	VBN	_	0	root	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1.3-fold	1.3-fold	RB	RB	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	expression	expression	NN	NN	_	6	nmod	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	stimulated	stimulate	VBN	VBN	_	6	advcl	_	_
15	under	under	IN	IN	_	17	case	_	_
16	anergic	anergic	JJ	JJ	_	17	amod	_	_
17	conditions	condition	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	while	while	IN	IN	_	26	mark	_	_
20	a	a	DT	DT	_	25	det	_	_
21	whole	whole	JJ	JJ	_	25	amod	_	_
22	mouse	mouse	NN	NN	_	25	compound	_	_
23	IL-2	il-2	NN	NN	_	25	compound	_	_
24	enhancer	enhancer	NN	NN	_	25	compound	_	_
25	construct	construct	NN	NN	_	26	nsubj	_	_
26	showed	show	VBD	VBD	_	6	advcl	_	_
27	a	a	DT	DT	_	28	det	_	_
28	reduction	reduction	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	4.3-fold	4.3-fold	JJ	JJ	_	28	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Addition	addition	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	-176	-176	CD	CD	_	7	compound	_	_
5	to	to	TO	TO	_	4	dep	_	_
6	-96	-96	CD	CD	_	4	dep	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	4X	4x	NN	NN	_	12	compound	_	_
11	NF-AT-Oct	nf-at-oct	NN	NN	_	12	compound	_	_
12	construct	construct	NN	NN	_	1	nmod	_	_
13	did	do	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	impart	impart	VB	VB	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	ability	ability	NN	NN	_	15	dobj	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	affected	affect	VBN	VBN	_	17	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	anergy	anergy	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	but	but	CC	CC	_	15	cc	_	_
25	addition	addition	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	-236	-236	CD	CD	_	31	compound	_	_
29	to	to	TO	TO	_	28	dep	_	_
30	-96	-96	CD	CD	_	28	dep	_	_
31	sequence	sequence	NN	NN	_	25	nmod	_	_
32	did	do	VBD	VBD	_	15	conj	_	_
33	,	,	,	,	_	15	punct	_	_
34	demonstrating	demonstrate	VBG	VBG	_	15	parataxis	_	_
35	that	that	IN	IN	_	41	mark	_	_
36	anergy	anergy	NN	NN	_	41	nsubj	_	_
37	is	be	VBZ	VBZ	_	41	cop	_	_
38	an	a	DT	DT	_	41	det	_	_
39	active	active	JJ	JJ	_	41	amod	_	_
40	inhibitory	inhibitory	JJ	JJ	_	41	amod	_	_
41	process	process	NN	NN	_	34	ccomp	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	that	that	IN	IN	_	60	mark	_	_
44	more	more	JJR	JJR	_	60	nsubjpass	_	_
45	than	than	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	presence	presence	NN	NN	_	44	nmod	_	_
48	of	of	IN	IN	_	53	case	_	_
49	the	the	DT	DT	_	53	det	_	_
50	-150	-150	CD	CD	_	53	nummod	_	_
51	AP-1	ap-1	NN	NN	_	53	compound	_	_
52	binding	binding	NN	NN	_	53	compound	_	_
53	site	site	NN	NN	_	47	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	-152	-152	CD	CD	_	53	dep	_	_
56	to	to	TO	TO	_	55	dep	_	_
57	-147	-147	CD	CD	_	55	dep	_	_
58	)	)	-RRB-	-RRB-	_	55	punct	_	_
59	is	be	VBZ	VBZ	_	60	auxpass	_	_
60	required	require	VBN	VBN	_	41	conj	_	_
61	to	to	TO	TO	_	62	mark	_	_
62	mediate	mediate	VB	VB	_	60	xcomp	_	_
63	the	the	DT	DT	_	64	det	_	_
64	effect	effect	NN	NN	_	62	dobj	_	_
65	.	.	.	.	_	15	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	-236	-236	CD	CD	_	8	compound	_	_
6	to	to	TO	TO	_	5	dep	_	_
7	-96	-96	CD	CD	_	5	dep	_	_
8	sequence	sequence	NN	NN	_	2	nmod	_	_
9	indicated	indicate	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	31	mark	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	31	nsubj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	both	both	CC	CC	_	18	cc:preconj	_	_
15	the	the	DT	DT	_	18	det	_	_
16	-130	-130	CD	CD	_	18	nummod	_	_
17	AP-1-like	ap-1-like	JJ	JJ	_	18	amod	_	_
18	site	site	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	-187	-187	CD	CD	_	18	dep	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	-181	-181	CD	CD	_	20	dep	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	the	the	DT	DT	_	29	det	_	_
26	-150	-150	CD	CD	_	29	nummod	_	_
27	proximal	proximal	JJ	JJ	_	29	amod	_	_
28	AP-1	ap-1	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	18	conj	_	_
30	were	be	VBD	VBD	_	31	cop	_	_
31	necessary	necessary	JJ	JJ	_	9	ccomp	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	observe	observe	VB	VB	_	31	xcomp	_	_
34	anergy	anergy	NN	NN	_	33	dobj	_	_
35	.	.	.	.	_	9	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	-180	-180	CD	CD	_	4	nummod	_	_
4	site	site	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	required	require	VBN	VBN	_	13	advcl	_	_
8	for	for	IN	IN	_	9	case	_	_
9	trans-activation	trans-activation	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	it	it	PRP	PRP	_	13	nsubj	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	possible	possible	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	confirm	confirm	VB	VB	_	13	xcomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	mutation	mutation	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	normal	normal	JJ	JJ	_	23	amod	_	_
21	mouse	mouse	NN	NN	_	23	compound	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	enhancer	enhancer	NN	NN	_	17	nmod	_	_
24	that	that	IN	IN	_	29	mark	_	_
25	this	this	DT	DT	_	26	det	_	_
26	site	site	NN	NN	_	29	nsubj	_	_
27	is	be	VBZ	VBZ	_	29	cop	_	_
28	absolutely	absolutely	RB	RB	_	29	advmod	_	_
29	essential	essential	JJ	JJ	_	15	ccomp	_	_
30	for	for	IN	IN	_	32	case	_	_
31	anergy	anergy	NN	NN	_	32	compound	_	_
32	induction	induction	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	simplest	simplest	JJS	JJS	_	3	amod	_	_
3	model	model	NN	NN	_	8	nsubj	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	explain	explain	VB	VB	_	3	acl	_	_
6	these	these	DT	DT	_	7	det	_	_
7	results	result	NNS	NNS	_	5	dobj	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	anergy	anergy	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	8	ccomp	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	complex	complex	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	multiple	multiple	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	15	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	exert	exert	VBP	VBP	_	19	acl:relcl	_	_
22	a	a	DT	DT	_	27	det	_	_
23	cis-acting	cis-acting	JJ	JJ	_	27	amod	_	_
24	dominant	dominant	JJ	JJ	_	27	amod	_	_
25	negative	negative	JJ	JJ	_	27	amod	_	_
26	regulatory	regulatory	JJ	JJ	_	27	amod	_	_
27	effect	effect	NN	NN	_	21	dobj	_	_
28	on	on	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	trans-activation	trans-activation	NN	NN	_	21	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	IL-2	il-2	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	11	case	_	_
3	the	the	DT	DT	_	11	det	_	_
4	human	human	JJ	JJ	_	11	amod	_	_
5	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
6	cell	cell	NN	NN	_	11	compound	_	_
7	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
8	differentiation	differentiation	NN	NN	_	11	compound	_	_
9	antigen	antigen	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	MNDA	mnda	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	7	punct	_	_
3	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	differentiation	differentiation	NN	NN	_	7	compound	_	_
7	antigen	antigen	NN	NN	_	1	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	15	cop	_	_
10	an	a	DT	DT	_	15	det	_	_
11	interferon	interferon	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	13	dep	_	_
13	regulated	regulate	VBN	VBN	_	15	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	0	root	_	_
16	expressed	express	VBN	VBN	_	15	acl	_	_
17	only	only	RB	RB	_	19	advmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	myelomonocytic	myelomonocytic	JJ	JJ	_	24	amod	_	_
24	lineage	lineage	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	21	advcl	_	_
3	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
4	responsible	responsible	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	10	case	_	_
6	this	this	DT	DT	_	10	det	_	_
7	lineage-specific	lineage-specific	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	interferon-regulated	interferon-regulated	JJ	JJ	_	7	conj	_	_
10	expression	expression	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	21	punct	_	_
12	the	the	DT	DT	_	15	det	_	_
13	5'	5'	JJ	JJ	_	15	amod	_	_
14	flanking	flanking	JJ	JJ	_	15	amod	_	_
15	sequence	sequence	NN	NN	_	21	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	gene	gene	NN	NN	_	15	nmod	_	_
19	has	have	VBZ	VBZ	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	characterized	characterize	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	Two	two	CD	CD	_	4	nummod	_	_
2	interferon-stimulated	interferon-stimulated	JJ	JJ	_	4	amod	_	_
3	response	response	NN	NN	_	4	compound	_	_
4	elements	element	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	ISRE	isre	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	flank	flank	VBP	VBP	_	0	root	_	_
9	a	a	DT	DT	_	14	det	_	_
10	multiple	multiple	JJ	JJ	_	14	amod	_	_
11	transcription	transcription	NN	NN	_	14	compound	_	_
12	start	start	NN	NN	_	14	compound	_	_
13	site	site	NN	NN	_	14	compound	_	_
14	region	region	NN	NN	_	8	dobj	_	_
15	identifying	identify	VBG	VBG	_	14	acl	_	_
16	MNDA	mnda	NN	NN	_	15	dobj	_	_
17	as	as	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	TATA-less	tata-less	JJ	JJ	_	21	amod	_	_
20	interferon-regulated	interferon-regulated	JJ	JJ	_	21	amod	_	_
21	gene	gene	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Other	other	JJ	JJ	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	elements	element	NNS	NNS	_	5	nsubj	_	_
4	present	present	JJ	JJ	_	3	amod	_	_
5	include	include	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cluster	cluster	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Myb	myb	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	several	several	JJ	JJ	_	13	amod	_	_
13	Ets	et	NNS	NNS	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	an	a	DT	DT	_	19	det	_	_
16	Ets	ets	NN	NN	_	17	nmod:npmod	_	_
17	related	related	JJ	JJ	_	19	amod	_	_
18	PU.1	pu.1	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	7	conj	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	an	a	DT	DT	_	23	det	_	_
22	Sp1	sp1	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	7	conj	_	_
24	located	located	JJ	JJ	_	7	amod	_	_
25	within	within	IN	IN	_	27	case	_	_
26	600	600	CD	CD	_	27	nummod	_	_
27	bp	bp	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	transcription	transcription	NN	NN	_	32	compound	_	_
31	start	start	NN	NN	_	32	compound	_	_
32	sites	site	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	methylation	methylation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	revealed	reveal	VBN	VBN	_	0	root	_	_
8	as	as	IN	IN	_	9	case	_	_
9	one	one	CD	CD	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	possible	possible	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	establishing	establish	VBG	VBG	_	9	acl	_	_
16	MNDA	mnda	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	5'	5'	JJ	JJ	_	4	amod	_	_
3	flanking	flanking	JJ	JJ	_	4	amod	_	_
4	sequence	sequence	NN	NN	_	5	nsubj	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	which	which	WDT	WDT	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	elevated	elevate	VBN	VBN	_	7	acl:relcl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	interferon	interferon	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	MNDA	mnda	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
9	by	by	IN	IN	_	10	case	_	_
10	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
11	similar	similar	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	17	case	_	_
13	other	other	JJ	JJ	_	17	amod	_	_
14	myelomonocytic	myelomonocytic	JJ	JJ	_	15	amod	_	_
15	cell	cell	NN	NN	_	16	nmod:npmod	_	_
16	specific	specific	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	genes	gene	NNS	NNS	_	17	conj	_	_
20	up-regulated	up-regulate	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	interferon	interferon	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	GM-CSF	gm-csf	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	core-binding	core-binding	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	GM-CSF	gm-csf	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	8	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	known	know	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	involve	involve	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	10	dobj	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	factor-kappa	factor-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	AP-1	ap-1	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	NFAT	nfat	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	Sp1	sp1	NN	NN	_	16	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	GM-CSF	gm-csf	NN	NN	_	12	nsubj	_	_
8	promoter	promoter	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	enhancer	enhancer	NN	NN	_	8	conj	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	encompass	encompass	VBP	VBP	_	3	ccomp	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	sites	site	NNS	NNS	_	12	dobj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	core-binding	core-binding	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CBF	cbf	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	Significantly	significantly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CBF	cbf	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	10	nsubjpass	_	_
6	are	be	VBP	VBP	_	10	auxpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	each	each	DT	DT	_	9	det	_	_
9	case	case	NN	NN	_	10	nmod	_	_
10	contained	contain	VBN	VBN	_	0	root	_	_
11	within	within	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	minimum	minimum	JJ	JJ	_	16	amod	_	_
14	essential	essential	JJ	JJ	_	16	amod	_	_
15	core	core	NN	NN	_	16	compound	_	_
16	regions	region	NNS	NNS	_	10	nmod	_	_
17	required	require	VBN	VBN	_	16	acl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	inducible	inducible	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	these	these	DT	DT	_	5	det	_	_
4	core	core	NN	NN	_	5	compound	_	_
5	regions	region	NNS	NNS	_	12	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	enhancer	enhancer	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	promoter	promoter	NN	NN	_	8	conj	_	_
11	each	each	DT	DT	_	8	dep	_	_
12	encompass	encompass	VBP	VBP	_	0	root	_	_
13	closely	closely	RB	RB	_	14	advmod	_	_
14	linked	link	VBN	VBN	_	16	amod	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	sites	site	NNS	NNS	_	12	dobj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	CBF	cbf	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	AP-1	ap-1	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	NFATp	nfatp	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	GM-CSF	gm-csf	NN	NN	_	6	compound	_	_
3	promoter	promoter	NN	NN	_	6	compound	_	_
4	CBF	cbf	NN	NN	_	6	compound	_	_
5	site	site	NN	NN	_	6	compound	_	_
6	TGTGGTCA	tgtggtca	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	located	located	JJ	JJ	_	0	root	_	_
9	51	51	CD	CD	_	10	compound	_	_
10	bp	bp	NN	NN	_	11	dep	_	_
11	upstream	upstream	RB	RB	_	8	advmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	start	start	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	also	also	RB	RB	_	8	advmod	_	_
19	overlaps	overlap	VBZ	VBZ	_	8	dep	_	_
20	a	a	DT	DT	_	23	det	_	_
21	YY-1	yy-1	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	2-bp	2-bp	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	8	nsubj	_	_
4	within	within	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CBF	cbf	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	3	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	2-3-fold	2-3-fold	JJ	JJ	_	12	amod	_	_
12	decrease	decrease	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activities	activity	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	both	both	CC	CC	_	22	cc:preconj	_	_
18	a	a	DT	DT	_	22	det	_	_
19	69-bp	69-bp	JJ	JJ	_	22	amod	_	_
20	proximal	proximal	JJ	JJ	_	22	amod	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	fragment	fragment	NN	NN	_	15	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	a	a	DT	DT	_	28	det	_	_
25	627-bp	627-bp	JJ	JJ	_	28	amod	_	_
26	full-length	full-length	NN	NN	_	28	compound	_	_
27	promoter	promoter	NN	NN	_	28	compound	_	_
28	fragment	fragment	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	Stepwise	stepwise	JJ	JJ	_	2	amod	_	_
2	deletions	deletion	NNS	NNS	_	8	nsubj	_	_
3	into	into	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	proximal	proximal	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	21	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CBF	cbf	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	21	nsubjpass	_	_
13	,	,	,	,	_	12	punct	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	12	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	YY-1	yy-1	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	8	ccomp	_	_
22	for	for	IN	IN	_	24	case	_	_
23	efficient	efficient	JJ	JJ	_	24	amod	_	_
24	induction	induction	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	activation	activation	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	AML1	aml1	NN	NN	_	6	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CBF	cbf	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	2	conj	_	_
6	genes	gene	NNS	NNS	_	11	nsubj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	encode	encode	VBP	VBP	_	6	acl:relcl	_	_
9	CBF	cbf	NN	NN	_	8	dobj	_	_
10	each	each	DT	DT	_	6	dep	_	_
11	have	have	VBP	VBP	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	influence	influence	VB	VB	_	13	acl	_	_
16	cell	cell	NN	NN	_	15	dobj	_	_
17	growth	growth	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	differentiation	differentiation	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	have	have	VBP	VBP	_	11	conj	_	_
22	been	be	VBN	VBN	_	21	dobj	_	_
23	implicated	implicate	VBN	VBN	_	22	dep	_	_
24	as	as	IN	IN	_	25	case	_	_
25	proto-oncogenes	proto-oncogene	NNS	NNS	_	23	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	acute	acute	JJ	JJ	_	29	amod	_	_
28	myeloid	myeloid	JJ	JJ	_	29	amod	_	_
29	leukemia	leukemia	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	adds	add	VBZ	VBZ	_	0	root	_	_
4	GM-CSF	gm-csf	NN	NN	_	3	dobj	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	growing	grow	VBG	VBG	_	8	amod	_	_
8	list	list	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	receptors	receptor	NNS	NNS	_	10	conj	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	regulated	regulate	VBN	VBN	_	10	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	CBF	cbf	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	control	control	VBP	VBP	_	15	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	growth	growth	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	22	punct	_	_
24	differentiation	differentiation	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	activation	activation	NN	NN	_	22	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	hemopoietic	hemopoietic	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	22	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	GM-CSF	gm-csf	NN	NN	_	3	compound	_	_
3	locus	locus	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	represent	represent	VB	VB	_	0	root	_	_
6	one	one	CD	CD	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	several	several	JJ	JJ	_	10	amod	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	dysregulated	dysregulate	VBN	VBN	_	10	acl:relcl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Mechanisms	mechanism	NNS	NNS	_	0	root	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	contribute	contribute	VBP	VBP	_	1	acl:relcl	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	development	development	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	lymphoid	lymphoid	JJ	JJ	_	9	amod	_	_
9	malignancies	malignancy	NNS	NNS	_	6	nmod	_	_
10	:	:	:	:	_	1	punct	_	_
11	roles	role	NNS	NNS	_	1	dep	_	_
12	for	for	IN	IN	_	14	case	_	_
13	genetic	genetic	JJ	JJ	_	14	amod	_	_
14	alterations	alteration	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	1	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	defined	define	VBN	VBN	_	0	root	_	_
5	genetic	genetic	JJ	JJ	_	6	amod	_	_
6	alterations	alteration	NNS	NNS	_	4	dobj	_	_
7	commonly	commonly	RB	RB	_	8	advmod	_	_
8	associated	associate	VBN	VBN	_	6	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	transformed	transform	VBN	VBN	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	roles	role	NNS	NNS	_	3	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	alterations	alteration	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	development	development	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
13	neoplasms	neoplasm	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Damage	damage	NN	NN	_	23	nsubjpass	_	_
2	to	to	TO	TO	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	encoding	encode	VBG	VBG	_	4	acl	_	_
6	proteins	protein	NNS	NNS	_	5	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	function	function	VBP	VBP	_	6	acl:relcl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
11	signaling	signaling	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	transcription	transcription	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	regulation	regulation	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	cycle	cycle	NN	NN	_	16	nmod	_	_
21	has	have	VBZ	VBZ	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	identified	identify	VBN	VBN	_	0	root	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	linked	link	VBN	VBN	_	23	conj	_	_
26	at	at	IN	IN	_	28	case	_	_
27	varying	vary	VBG	VBG	_	28	amod	_	_
28	degrees	degree	NNS	NNS	_	25	nmod	_	_
29	to	to	TO	TO	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	progression	progression	NN	NN	_	25	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	certain	certain	JJ	JJ	_	35	amod	_	_
34	lymphoid	lymphoid	JJ	JJ	_	35	amod	_	_
35	malignancies	malignancy	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	23	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	understanding	understanding	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	mechanistic	mechanistic	JJ	JJ	_	6	amod	_	_
6	consequences	consequence	NNS	NNS	_	2	nmod	_	_
7	following	follow	VBG	VBG	_	6	acl	_	_
8	such	such	JJ	JJ	_	10	amod	_	_
9	genetic	genetic	JJ	JJ	_	10	amod	_	_
10	alterations	alteration	NNS	NNS	_	7	dobj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	essential	essential	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	understanding	understanding	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	development	development	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	these	these	DT	DT	_	22	det	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	neoplasms	neoplasm	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	it	it	PRP	PRP	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	becoming	become	VBG	VBG	_	0	root	_	_
8	clear	clear	JJ	JJ	_	7	xcomp	_	_
9	that	that	IN	IN	_	22	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	dysregulated	dysregulate	VBN	VBN	_	12	amod	_	_
12	expression	expression	NN	NN	_	22	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	proteins	protein	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	19	nsubjpass	_	_
16	are	be	VBP	VBP	_	19	auxpass	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	genetically	genetically	RB	RB	_	19	advmod	_	_
19	altered	alter	VBN	VBN	_	14	acl:relcl	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	contribute	contribute	VB	VB	_	7	ccomp	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	progression	progression	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	lymphoid	lymphoid	JJ	JJ	_	28	amod	_	_
28	malignancies	malignancy	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	such	such	JJ	JJ	_	3	amod	_	_
3	example	example	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	the	the	DT	DT	_	7	det	_	_
6	excessive	excessive	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	0	root	_	_
8	of	of	IN	IN	_	11	case	_	_
9	``	``	``	``	_	11	punct	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	lymphokines	lymphokine	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	accompanies	accompany	VBZ	VBZ	_	7	acl:relcl	_	_
16	many	many	JJ	JJ	_	18	amod	_	_
17	lymphoproliferative	lymphoproliferative	JJ	JJ	_	18	amod	_	_
18	diseases	disease	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	dysregulated	dysregulate	VBN	VBN	_	3	amod	_	_
3	expression	expression	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cytokines	cytokine	NNS	NNS	_	3	nmod	_	_
6	during	during	IN	IN	_	7	case	_	_
7	malignancy	malignancy	NN	NN	_	3	nmod	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	result	result	VB	VB	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	augmentation	augmentation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	growth	growth	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transformed	transform	VBN	VBN	_	17	amod	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	as	as	RB	RB	_	12	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	an	a	DT	DT	_	23	det	_	_
23	alteration	alteration	NN	NN	_	12	conj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	anti-tumor	anti-tumor	JJ	JJ	_	28	amod	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	response	response	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	especially	especially	RB	RB	_	6	advmod	_	_
6	important	important	JJ	JJ	_	0	root	_	_
7	because	because	IN	IN	_	16	mark	_	_
8	evasion	evasion	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	impending	impending	JJ	JJ	_	13	amod	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	response	response	NN	NN	_	8	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	prerequisite	prerequisite	NN	NN	_	6	advcl	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	progression	progression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	lymphoproliferative	lymphoproliferative	JJ	JJ	_	22	amod	_	_
22	diseases	disease	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	review	review	NN	NN	_	6	nsubj	_	_
6	supports	support	VBZ	VBZ	_	1	parataxis	_	_
7	the	the	DT	DT	_	8	det	_	_
8	notion	notion	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	development	development	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	lymphoid	lymphoid	JJ	JJ	_	14	amod	_	_
14	malignancies	malignancy	NNS	NNS	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	multifactorial	multifactorial	JJ	JJ	_	8	ccomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	involving	involve	VBG	VBG	_	16	xcomp	_	_
19	genetic	genetic	JJ	JJ	_	20	amod	_	_
20	alterations	alteration	NNS	NNS	_	18	dobj	_	_
21	as	as	RB	RB	_	20	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	dysregulated	dysregulate	VBN	VBN	_	26	amod	_	_
25	cytokine	cytokine	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	20	conj	_	_
27	.	.	.	.	_	1	punct	_	_

1	Tyloxapol	tyloxapol	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cytokine	cytokine	NN	NN	_	4	conj	_	_
7	release	release	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	2	punct	_	_
9	scavenges	scavenge	VBZ	VBZ	_	2	conj	_	_
10	HOCI	hoci	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	2	punct	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	reduces	reduce	VBZ	VBZ	_	2	conj	_	_
14	viscosity	viscosity	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	cystic	cystic	JJ	JJ	_	18	amod	_	_
17	fibrosis	fibrosis	NN	NN	_	18	compound	_	_
18	sputum	sputum	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Cystic	cystic	JJ	JJ	_	2	amod	_	_
2	fibrosis	fibrosis	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CF	cf	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	patients	patient	NNS	NNS	_	7	nsubj	_	_
7	develop	develop	VB	VB	_	0	root	_	_
8	progressive	progressive	JJ	JJ	_	12	amod	_	_
9	cytokine-mediated	cytokine-mediated	JJ	JJ	_	12	amod	_	_
10	inflammatory	inflammatory	JJ	JJ	_	12	amod	_	_
11	lung	lung	NN	NN	_	12	compound	_	_
12	disease	disease	NN	NN	_	7	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	with	with	IN	IN	_	16	case	_	_
15	abundant	abundant	JJ	JJ	_	16	amod	_	_
16	production	production	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	27	case	_	_
18	thick	thick	JJ	JJ	_	27	amod	_	_
19	,	,	,	,	_	18	punct	_	_
20	tenacious	tenacious	JJ	JJ	_	18	dep	_	_
21	,	,	,	,	_	18	punct	_	_
22	protease-	protease-	NN	NN	_	18	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	oxidant-rich	oxidant-rich	JJ	JJ	_	22	conj	_	_
25	purulent	purulent	JJ	JJ	_	27	amod	_	_
26	airway	airway	NN	NN	_	27	compound	_	_
27	secretions	secretion	NNS	NNS	_	16	nmod	_	_
28	that	that	WDT	WDT	_	30	nsubj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	difficult	difficult	JJ	JJ	_	27	acl:relcl	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	clear	clear	VB	VB	_	30	ccomp	_	_
33	even	even	RB	RB	_	35	advmod	_	_
34	with	with	IN	IN	_	35	case	_	_
35	physiotherapy	physiotherapy	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	search	search	NN	NN	_	11	nmod	_	_
4	for	for	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	potential	potential	JJ	JJ	_	7	amod	_	_
7	treatment	treatment	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	we	we	PRP	PRP	_	11	nsubj	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	tested	test	VBN	VBN	_	0	root	_	_
12	tyloxapol	tyloxapol	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	an	a	DT	DT	_	19	det	_	_
15	alkylaryl	alkylaryl	NN	NN	_	19	compound	_	_
16	polyether	polyether	JJ	JJ	_	19	amod	_	_
17	alcohol	alcohol	NN	NN	_	19	compound	_	_
18	polymer	polymer	NN	NN	_	19	compound	_	_
19	detergent	detergent	NN	NN	_	12	appos	_	_
20	previously	previously	RB	RB	_	21	advmod	_	_
21	used	use	VBN	VBN	_	19	acl	_	_
22	as	as	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	mucolytic	mucolytic	JJ	JJ	_	25	amod	_	_
25	agent	agent	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	adult	adult	JJ	JJ	_	29	amod	_	_
28	chronic	chronic	JJ	JJ	_	29	amod	_	_
29	bronchitis	bronchitis	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	11	punct	_	_

1	Tyloxapol	tyloxapol	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	nmod	_	_
8	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
9	factor-kappa	factor-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	dep	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	NK-kappa	nk-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	2	punct	_	_
16	reduces	reduce	VBZ	VBZ	_	2	conj	_	_
17	resting	rest	VBG	VBG	_	18	amod	_	_
18	secretion	secretion	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytokine	cytokine	NN	NN	_	18	nmod	_	_
22	interleukin-8	interleukin-8	NN	NN	_	21	dep	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	IL-8	il-8	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	in	in	IN	IN	_	29	case	_	_
27	cultured	culture	VBN	VBN	_	29	amod	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
30	,	,	,	,	_	2	punct	_	_
31	and	and	CC	CC	_	2	cc	_	_
32	inhibits	inhibit	VBZ	VBZ	_	2	conj	_	_
33	lipopolysaccharide	lipopolysaccharide	NN	NN	_	37	nmod:npmod	_	_
34	(	(	-LRB-	-LRB-	_	37	punct	_	_
35	LPS	lps	NN	NN	_	37	nmod:npmod	_	_
36	)	)	-RRB-	-RRB-	_	37	punct	_	_
37	-stimulated	-stimulated	JJ	JJ	_	38	amod	_	_
38	release	release	NN	NN	_	32	dobj	_	_
39	of	of	IN	IN	_	42	case	_	_
40	tumor	tumor	NN	NN	_	42	compound	_	_
41	necrosis	necrosis	NN	NN	_	42	compound	_	_
42	factor-alpha	factor-alpha	NN	NN	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	TNF-alpha	tnf-alpha	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	,	,	,	,	_	42	punct	_	_
47	IL-1	il-1	NN	NN	_	48	compound	_	_
48	beta	beta	NN	NN	_	42	conj	_	_
49	,	,	,	,	_	42	punct	_	_
50	IL-6	il-6	NN	NN	_	42	conj	_	_
51	,	,	,	,	_	42	punct	_	_
52	IL-8	il-8	NN	NN	_	42	conj	_	_
53	,	,	,	,	_	42	punct	_	_
54	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	56	amod	_	_
55	colony-stimulating	colony-stimulating	JJ	JJ	_	56	amod	_	_
56	factor	factor	NN	NN	_	42	conj	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	GM-CSF	gm-csf	NN	NN	_	56	appos	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	,	,	,	,	_	42	punct	_	_
61	and	and	CC	CC	_	42	cc	_	_
62	the	the	DT	DT	_	63	det	_	_
63	eiconsanoids	eiconsanoid	NNS	NNS	_	42	conj	_	_
64	thromboxane	thromboxane	NN	NN	_	65	compound	_	_
65	A2	a2	NN	NN	_	63	dep	_	_
66	and	and	CC	CC	_	65	cc	_	_
67	leukotriene	leukotriene	NN	NN	_	68	compound	_	_
68	B4	b4	NN	NN	_	65	conj	_	_
69	(	(	-LRB-	-LRB-	_	70	punct	_	_
70	LTB4	ltb4	NN	NN	_	68	appos	_	_
71	)	)	-RRB-	-RRB-	_	70	punct	_	_
72	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	tyloxapol	tyloxapol	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	potent	potent	JJ	JJ	_	10	amod	_	_
10	antioxidant	antioxidant	NN	NN	_	4	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	hydroxyl	hydroxyl	NN	NN	_	13	compound	_	_
13	radicals	radical	NNS	NNS	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	OH	oh	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	4	punct	_	_

1	Tyloxapol	tyloxapol	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	7	punct	_	_
3	0.05	0.05	CD	CD	_	5	compound	_	_
4	to	to	TO	TO	_	5	dep	_	_
5	0.1	0.1	CD	CD	_	6	dep	_	_
6	%	%	NN	NN	_	7	dep	_	_
7	wt/vol	wt/vol	NN	NN	_	1	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	effectively	effectively	RB	RB	_	10	advmod	_	_
10	scavenges	scavenge	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	oxidant	oxidant	JJ	JJ	_	14	amod	_	_
13	hypochlorous	hypochlorous	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	10	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HOCl	hocl	NN	NN	_	14	dep	_	_
17	;	;	:	:	_	16	punct	_	_
18	1	1	CD	CD	_	20	compound	_	_
19	to	to	TO	TO	_	20	dep	_	_
20	7.5	7.5	CD	CD	_	21	nummod	_	_
21	mM	mm	NN	NN	_	16	dep	_	_
22	)	)	-RRB-	-RRB-	_	16	punct	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	10	advmod	_	_
25	,	,	,	,	_	10	punct	_	_
26	and	and	CC	CC	_	10	cc	_	_
27	protects	protect	VBZ	VBZ	_	10	conj	_	_
28	from	from	IN	IN	_	31	case	_	_
29	HOCl-mediated	hocl-mediated	JJ	JJ	_	31	amod	_	_
30	lung	lung	NN	NN	_	31	compound	_	_
31	injury	injury	NN	NN	_	27	nmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	rats	rat	NNS	NNS	_	27	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	Tyloxapol	tyloxapol	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	reduces	reduce	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	viscosity	viscosity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	CF	cf	NN	NN	_	8	compound	_	_
8	sputum	sputum	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	3	punct	_	_
10	from	from	IN	IN	_	11	case	_	_
11	463	463	CD	CD	_	3	nmod	_	_
12	+/-	+/-	CC	CC	_	11	cc	_	_
13	133	133	CD	CD	_	11	conj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	128	128	CD	CD	_	3	nmod	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	52	52	CD	CD	_	15	conj	_	_
18	centipoise	centipoise	NN	NN	_	3	dobj	_	_
19	)	)	-RRB-	-RRB-	_	3	punct	_	_
20	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	tyloxapol	tyloxapol	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	potentially	potentially	RB	RB	_	7	advmod	_	_
7	useful	useful	JJ	JJ	_	2	ccomp	_	_
8	as	as	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	new	new	JJ	JJ	_	12	amod	_	_
11	antiinflammatory	antiinflammatory	JJ	JJ	_	12	amod	_	_
12	therapy	therapy	NN	NN	_	7	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	CF	cf	NN	NN	_	16	compound	_	_
15	lung	lung	NN	NN	_	16	compound	_	_
16	disease	disease	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	could	could	MD	MD	_	21	aux	_	_
20	possibly	possibly	RB	RB	_	21	advmod	_	_
21	promote	promote	VB	VB	_	7	conj	_	_
22	clearance	clearance	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	secretions	secretion	NNS	NNS	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	CF	cf	NN	NN	_	28	compound	_	_
28	airway	airway	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Abnormality	abnormality	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Oct-1	oct-1	NN	NN	_	5	compound	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	13	case	_	_
10	Sjogren	sjogren	NN	NN	_	13	nmod:poss	_	_
11	's	's	POS	POS	_	10	case	_	_
12	syndrome	syndrome	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Primary	primary	JJ	JJ	_	4	amod	_	_
2	Sjogren	sjogren	NN	NN	_	4	nmod:poss	_	_
3	's	's	POS	POS	_	2	case	_	_
4	syndrome	syndrome	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SS	ss	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	an	a	DT	DT	_	12	det	_	_
10	autoimmune	autoimmune	JJ	JJ	_	12	amod	_	_
11	rheumatic	rheumatic	JJ	JJ	_	12	amod	_	_
12	disease	disease	NN	NN	_	0	root	_	_
13	characterized	characterize	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	hypoactivity	hypoactivity	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	7	det	_	_
4	diminished	diminish	VBN	VBN	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	response	response	NN	NN	_	2	dobj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	activation	activation	NN	NN	_	10	compound	_	_
10	signals	signal	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	measured	measure	VBD	VBD	_	0	root	_	_
14	nucleoprotein	nucleoprotein	NN	NN	_	16	compound	_	_
15	DNA-binding	dna-binding	JJ	JJ	_	16	amod	_	_
16	activities	activity	NNS	NNS	_	13	dobj	_	_
17	regulating	regulate	VBG	VBG	_	16	acl	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	during	during	IN	IN	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	17	nmod	_	_
24	using	use	VBG	VBG	_	13	xcomp	_	_
25	the	the	DT	DT	_	29	det	_	_
26	electrophoretic	electrophoretic	JJ	JJ	_	29	amod	_	_
27	mobility	mobility	NN	NN	_	29	compound	_	_
28	shift	shift	NN	NN	_	29	compound	_	_
29	assay	assay	NN	NN	_	24	dobj	_	_
30	.	.	.	.	_	13	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	9	nsubjpass	_	_
4	from	from	IN	IN	_	7	case	_	_
5	9/19	9/19	CD	CD	_	7	nummod	_	_
6	SS	ss	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	defective	defective	JJ	JJ	_	9	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	bind	bind	VB	VB	_	15	acl	_	_
18	an	a	DT	DT	_	20	det	_	_
19	october	october	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	17	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	Oct-1	oct-1	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	Oct-1-binding	oct-1-binding	JJ	JJ	_	3	amod	_	_
3	phenotype	phenotype	NN	NN	_	4	nsubj	_	_
4	remained	remain	VBD	VBD	_	0	root	_	_
5	stable	stable	JJ	JJ	_	4	xcomp	_	_
6	in	in	IN	IN	_	7	case	_	_
7	culture	culture	NN	NN	_	4	nmod	_	_
8	for	for	IN	IN	_	12	case	_	_
9	up	up	IN	IN	_	11	dep	_	_
10	to	to	TO	TO	_	9	mwe	_	_
11	3	3	CD	CD	_	12	nummod	_	_
12	days	day	NNS	NNS	_	4	nmod	_	_
13	prior	prior	RB	RB	_	15	case	_	_
14	to	to	TO	TO	_	13	mwe	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	abnormality	abnormality	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	seen	see	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	resting	rest	VBG	VBG	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	nor	nor	CC	CC	_	9	cc	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	9	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	systemic	systemic	JJ	JJ	_	18	amod	_	_
17	lupus	lupus	NN	NN	_	18	compound	_	_
18	erythematosus	erythematosus	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	rheumatoid	rheumatoid	JJ	JJ	_	21	amod	_	_
21	arthritis	arthritis	NN	NN	_	18	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RA	ra	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	18	punct	_	_
26	or	or	CC	CC	_	18	cc	_	_
27	SS	ss	NN	NN	_	18	conj	_	_
28	accompanied	accompany	VBN	VBN	_	27	acl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	RA	ra	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	SS	ss	NN	NN	_	5	compound	_	_
3	Oct-1	oct-1	NN	NN	_	5	compound	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	abnormality	abnormality	NN	NN	_	6	nsubj	_	_
6	correlated	correlate	VBD	VBD	_	0	root	_	_
7	significantly	significantly	RB	RB	_	6	advmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	inability	inability	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	exit	exit	VB	VB	_	10	acl	_	_
15	the	the	DT	DT	_	19	det	_	_
16	Gzero/G1	gzero/g1	NN	NN	_	19	compound	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	cycle	cycle	NN	NN	_	19	compound	_	_
19	phase	phase	NN	NN	_	14	dobj	_	_
20	when	when	WRB	WRB	_	21	advmod	_	_
21	stimulated	stimulate	VBN	VBN	_	14	advcl	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	21	advmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Importantly	importantly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	nucleoprotein	nucleoprotein	NN	NN	_	4	compound	_	_
4	extracts	extract	NNS	NNS	_	9	nsubj	_	_
5	showing	show	VBG	VBG	_	4	acl	_	_
6	decreased	decrease	VBN	VBN	_	8	amod	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	had	have	VBD	VBD	_	0	root	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	amounts	amount	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Oct-1	oct-1	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	determined	determine	VBN	VBN	_	11	dep	_	_
17	by	by	IN	IN	_	18	case	_	_
18	immunoprecipitation	immunoprecipitation	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	implying	imply	VBG	VBG	_	9	advcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	functional	functional	JJ	JJ	_	23	amod	_	_
23	defect	defect	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	Oct-1	oct-1	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	defective	defective	JJ	JJ	_	5	amod	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	corrected	correct	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	treatment	treatment	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	acid	acid	NN	NN	_	12	compound	_	_
12	phosphatase	phosphatase	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Severe	severe	JJ	JJ	_	3	amod	_	_
2	combined	combined	JJ	JJ	_	3	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	0	root	_	_
4	due	due	IN	IN	_	7	case	_	_
5	to	to	TO	TO	_	4	mwe	_	_
6	defective	defective	JJ	JJ	_	7	amod	_	_
7	binding	binding	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	two	two	CD	CD	_	22	nummod	_	_
21	male	male	JJ	JJ	_	22	amod	_	_
22	siblings	sibling	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	29	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PBL	pbl	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	alloreactive	alloreactive	JJ	JJ	_	11	amod	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	3	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	male	male	JJ	JJ	_	15	amod	_	_
15	infants	infant	NNS	NNS	_	3	nmod	_	_
16	born	bear	VBN	VBN	_	15	dep	_	_
17	to	to	TO	TO	_	19	case	_	_
18	consanguinous	consanguinous	JJ	JJ	_	19	amod	_	_
19	parents	parent	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	presenting	present	VBG	VBG	_	16	conj	_	_
22	with	with	IN	IN	_	25	case	_	_
23	severe	severe	JJ	JJ	_	25	amod	_	_
24	combined	combined	JJ	JJ	_	25	amod	_	_
25	immunodeficiency	immunodeficiency	NN	NN	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	SCID	scid	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	showed	show	VBD	VBD	_	0	root	_	_
30	a	a	DT	DT	_	32	det	_	_
31	pronounced	pronounced	JJ	JJ	_	32	amod	_	_
32	deficiency	deficiency	NN	NN	_	29	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	T	t	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	29	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	phenotypically	phenotypically	RB	RB	_	3	advmod	_	_
3	normal	normal	JJ	JJ	_	16	advcl	_	_
4	,	,	,	,	_	16	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	proliferative	proliferative	JJ	JJ	_	7	amod	_	_
7	response	response	NN	NN	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	childrens	children	NNS	NNS	_	13	nmod:poss	_	_
11	'	'	POS	POS	_	10	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	strongly	strongly	RB	RB	_	16	advmod	_	_
16	reduced	reduce	VBN	VBN	_	0	root	_	_
17	but	but	CC	CC	_	16	cc	_	_
18	could	could	MD	MD	_	20	aux	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	improved	improve	VBN	VBN	_	16	conj	_	_
21	by	by	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	addition	addition	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	interleukin-2	interleukin-2	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IL-2	il-2	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	16	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	both	both	DT	DT	_	3	det	_	_
3	childrens	children	NNS	NNS	_	6	nmod:poss	_	_
4	'	'	POS	POS	_	3	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	unable	unable	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	produce	produce	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cytokines	cytokine	NNS	NNS	_	10	dobj	_	_
13	IL-2	il-2	NN	NN	_	12	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	interferon-gamma	interferon-gamma	NN	NN	_	13	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	13	punct	_	_
20	IL-4	il-4	NN	NN	_	13	conj	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	tumor	tumor	NN	NN	_	24	compound	_	_
23	necrosis	necrosis	NN	NN	_	24	compound	_	_
24	factor-alpha	factor-alpha	NN	NN	_	13	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	multiple	multiple	JJ	JJ	_	5	amod	_	_
3	cytokine	cytokine	NN	NN	_	5	compound	_	_
4	production	production	NN	NN	_	5	compound	_	_
5	deficiency	deficiency	NN	NN	_	9	nsubjpass	_	_
6	could	could	MD	MD	_	9	aux	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	restored	restore	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	IL-2	il-2	NN	NN	_	14	compound	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	co-stimulatory	co-stimulatory	JJ	JJ	_	11	conj	_	_
14	signals	signal	NNS	NNS	_	9	nmod	_	_
15	provided	provide	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	antigen-presenting	antigen-presenting	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	APC	apc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	mRNA	mrna	NN	NN	_	11	nsubjpass	_	_
4	for	for	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	5	conj	_	_
8	could	could	MD	MD	_	11	aux	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	expression	expression	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	activation-dependent	activation-dependent	JJ	JJ	_	10	amod	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	markers	marker	NNS	NNS	_	4	nmod	_	_
11	CD25	cd25	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CD69	cd69	NN	NN	_	11	conj	_	_
14	was	be	VBD	VBD	_	17	cop	_	_
15	within	within	IN	IN	_	17	case	_	_
16	normal	normal	JJ	JJ	_	17	amod	_	_
17	limits	limit	NNS	NNS	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	35	advcl	_	_
3	whether	whether	IN	IN	_	17	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	defect	defect	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	patients	patient	NNS	NNS	_	12	nmod:poss	_	_
10	'	'	POS	POS	_	9	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	was	be	VBD	VBD	_	17	cop	_	_
14	due	due	JJ	JJ	_	17	case	_	_
15	to	to	TO	TO	_	14	mwe	_	_
16	the	the	DT	DT	_	17	det	_	_
17	absence	absence	NN	NN	_	2	ccomp	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	abnormal	abnormal	JJ	JJ	_	20	amod	_	_
20	binding	binding	NN	NN	_	17	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	17	nmod	_	_
24	involved	involve	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	28	case	_	_
26	cytokine	cytokine	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	35	punct	_	_
30	electrophoretic	electrophoretic	JJ	JJ	_	33	amod	_	_
31	mobility	mobility	NN	NN	_	33	compound	_	_
32	shift	shift	NN	NN	_	33	compound	_	_
33	assays	assay	NNS	NNS	_	35	nsubjpass	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	used	use	VBN	VBN	_	0	root	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	examine	examine	VB	VB	_	35	xcomp	_	_
38	the	the	DT	DT	_	40	det	_	_
39	DNA	dna	NN	NN	_	40	compound	_	_
40	binding	binding	NN	NN	_	37	dobj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	AP-1	ap-1	NN	NN	_	40	nmod	_	_
43	,	,	,	,	_	42	punct	_	_
44	Oct	oct	NN	NN	_	42	conj	_	_
45	,	,	,	,	_	42	punct	_	_
46	CREB	creb	NN	NN	_	42	conj	_	_
47	,	,	,	,	_	42	punct	_	_
48	SP1	sp1	NN	NN	_	42	conj	_	_
49	,	,	,	,	_	42	punct	_	_
50	NF-kappa	nf-kappa	NN	NN	_	51	compound	_	_
51	B	b	NN	NN	_	42	conj	_	_
52	and	and	CC	CC	_	42	cc	_	_
53	the	the	DT	DT	_	55	det	_	_
54	nuclear	nuclear	JJ	JJ	_	55	amod	_	_
55	factor	factor	NN	NN	_	42	conj	_	_
56	of	of	IN	IN	_	59	case	_	_
57	activated	activate	VBN	VBN	_	59	amod	_	_
58	T	t	NN	NN	_	59	compound	_	_
59	cells	cell	NNS	NNS	_	55	nmod	_	_
60	(	(	-LRB-	-LRB-	_	61	punct	_	_
61	NF-AT	nf-at	NN	NN	_	55	appos	_	_
62	)	)	-RRB-	-RRB-	_	61	punct	_	_
63	to	to	TO	TO	_	67	case	_	_
64	their	they	PRP$	PRP$	_	67	nmod:poss	_	_
65	respective	respective	JJ	JJ	_	67	amod	_	_
66	response	response	NN	NN	_	67	compound	_	_
67	elements	element	NNS	NNS	_	40	nmod	_	_
68	in	in	IN	IN	_	70	case	_	_
69	the	the	DT	DT	_	70	det	_	_
70	promoter	promoter	NN	NN	_	67	nmod	_	_
71	of	of	IN	IN	_	74	case	_	_
72	the	the	DT	DT	_	74	det	_	_
73	IL-2	il-2	NN	NN	_	74	compound	_	_
74	gene	gene	NN	NN	_	70	nmod	_	_
75	.	.	.	.	_	35	punct	_	_

1	Whereas	whereas	IN	IN	_	12	mark	_	_
2	AP-1	ap-1	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	conj	_	_
6	,	,	,	,	_	2	punct	_	_
7	Oct	oct	NN	NN	_	2	conj	_	_
8	,	,	,	,	_	2	punct	_	_
9	CREB	creb	NN	NN	_	2	conj	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	SP1	sp1	NN	NN	_	2	conj	_	_
12	displayed	display	VBD	VBD	_	32	advcl	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	activities	activity	NNS	NNS	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	32	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	binding	binding	NN	NN	_	32	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-AT	nf-at	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	29	case	_	_
25	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
26	IL-2	il-2	NN	NN	_	29	compound	_	_
27	promoter	promoter	NN	NN	_	29	compound	_	_
28	response	response	NN	NN	_	29	compound	_	_
29	element	element	NN	NN	_	21	nmod	_	_
30	was	be	VBD	VBD	_	32	cop	_	_
31	barely	barely	RB	RB	_	32	advmod	_	_
32	detectable	detectable	JJ	JJ	_	0	root	_	_
33	both	both	CC	CC	_	34	cc:preconj	_	_
34	before	before	IN	IN	_	39	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	after	after	IN	IN	_	34	conj	_	_
37	T	t	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	stimulation	stimulation	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	32	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	this	this	DT	DT	_	9	det	_	_
7	NF-AT/DNA	nf-at/dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	defect	defect	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsible	responsible	JJ	JJ	_	4	ccomp	_	_
12	for	for	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	deficiency	deficiency	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	SCID	scid	NN	NN	_	20	compound	_	_
20	phenotype	phenotype	NN	NN	_	16	conj	_	_
21	observed	observe	VBN	VBN	_	16	acl	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	two	two	CD	CD	_	26	nummod	_	_
25	infant	infant	JJ	JJ	_	26	amod	_	_
26	brothers	brother	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Requirements	requirement	NNS	NNS	_	0	root	_	_
2	for	for	IN	IN	_	3	case	_	_
3	induction	induction	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	vitamin	vitamin	NN	NN	_	6	nmod:npmod	_	_
6	D-mediated	d-mediated	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	regulation	regulation	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Mature	mature	JJ	JJ	_	3	amod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	unique	unique	JJ	JJ	_	6	amod	_	_
6	targets	target	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	1	1	CD	CD	_	10	nummod	_	_
9	alpha,25-dihydroxyvitamin	alpha,25-dihydroxyvitamin	NN	NN	_	10	compound	_	_
10	D3	d3	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	alpha,25(OH)2D3	alpha,25(oh)2d3	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	26	mark	_	_
16	that	that	IN	IN	_	26	mark	_	_
17	vitamin	vitamin	NN	NN	_	19	compound	_	_
18	D	d	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	26	nsubjpass	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	VDR	vdr	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	are	be	VBP	VBP	_	26	auxpass	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	constitutively	constitutively	RB	RB	_	26	advmod	_	_
26	expressed	express	VBN	VBN	_	6	advcl	_	_
27	,	,	,	,	_	26	punct	_	_
28	and	and	CC	CC	_	26	cc	_	_
29	specific	specific	JJ	JJ	_	32	amod	_	_
30	cellular	cellular	JJ	JJ	_	32	amod	_	_
31	activation	activation	NN	NN	_	32	compound	_	_
32	signals	signal	NNS	NNS	_	34	nsubjpass	_	_
33	are	be	VBP	VBP	_	34	auxpass	_	_
34	required	require	VBN	VBN	_	26	conj	_	_
35	for	for	IN	IN	_	38	case	_	_
36	both	both	DT	DT	_	38	cc:preconj	_	_
37	the	the	DT	DT	_	38	det	_	_
38	up-regulation	up-regulation	NN	NN	_	34	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	VDR	vdr	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	38	cc	_	_
42	establishment	establishment	NN	NN	_	38	conj	_	_
43	of	of	IN	IN	_	44	case	_	_
44	reactivity	reactivity	NN	NN	_	42	nmod	_	_
45	to	to	TO	TO	_	48	case	_	_
46	the	the	DT	DT	_	48	det	_	_
47	lipophilic	lipophilic	JJ	JJ	_	48	amod	_	_
48	ligand	ligand	NN	NN	_	44	nmod	_	_
49	.	.	.	.	_	6	punct	_	_

1	Treatment	treatment	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	IL-4	il-4	NN	NN	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-4	il-4	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	20	punct	_	_
13	in	in	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	dep	_	_
15	absence	absence	NN	NN	_	18	dep	_	_
16	of	of	IN	IN	_	18	case	_	_
17	prior	prior	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	20	nmod	_	_
19	,	,	,	,	_	20	punct	_	_
20	induces	induce	VBZ	VBZ	_	0	root	_	_
21	a	a	DT	DT	_	23	det	_	_
22	weak	weak	JJ	JJ	_	23	amod	_	_
23	up-regulation	up-regulation	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	VDR	vdr	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	but	but	CC	CC	_	20	cc	_	_
28	fails	fail	VBZ	VBZ	_	20	conj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	generate	generate	VB	VB	_	28	ccomp	_	_
31	vitamin	vitamin	NN	NN	_	32	nmod:npmod	_	_
32	D-responsive	d-responsive	JJ	JJ	_	33	amod	_	_
33	element	element	NN	NN	_	37	dep	_	_
34	(	(	-LRB-	-LRB-	_	37	punct	_	_
35	VDRE	vdre	NN	NN	_	37	nmod:npmod	_	_
36	)	)	-RRB-	-RRB-	_	37	punct	_	_
37	-reactive	-reactive	JJ	JJ	_	40	amod	_	_
38	nuclear	nuclear	JJ	JJ	_	40	amod	_	_
39	protein	protein	NN	NN	_	40	compound	_	_
40	complexes	complex	NNS	NNS	_	30	dobj	_	_
41	or	or	CC	CC	_	30	cc	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	initiate	initiate	VB	VB	_	30	conj	_	_
44	the	the	DT	DT	_	46	det	_	_
45	genomic	genomic	JJ	JJ	_	46	amod	_	_
46	transcription	transcription	NN	NN	_	43	dobj	_	_
47	of	of	IN	IN	_	50	case	_	_
48	25-hydroxyvitamin	25-hydroxyvitamin	NN	NN	_	50	compound	_	_
49	D3	d3	NN	NN	_	50	compound	_	_
50	24-hydroxylase	24-hydroxylase	NN	NN	_	46	nmod	_	_
51	.	.	.	.	_	20	punct	_	_

1	Stimulation	stimulation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	either	either	CC	CC	_	1	acl	_	_
7	ligation	ligation	NN	NN	_	6	dep	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CD40	cd40	NN	NN	_	10	compound	_	_
10	Ag	ag	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	6	cc	_	_
12	cross-linking	cross-link	VBG	VBG	_	6	conj	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Ig	ig	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	12	dobj	_	_
16	is	be	VBZ	VBZ	_	18	cop	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	insufficient	insufficient	JJ	JJ	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	render	render	VB	VB	_	18	xcomp	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	23	nsubj	_	_
23	responsive	responsive	JJ	JJ	_	20	xcomp	_	_
24	to	to	TO	TO	_	26	case	_	_
25	1	1	CD	CD	_	26	nummod	_	_
26	alpha,25(OH)2D3	alpha,25(oh)2d3	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	apparent	apparent	JJ	JJ	_	5	amod	_	_
5	lack	lack	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	secosterol	secosterol	NN	NN	_	7	nmod	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	overcome	overcome	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	combination	combination	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	these	these	DT	DT	_	26	det	_	_
24	cellular	cellular	JJ	JJ	_	26	amod	_	_
25	activation	activation	NN	NN	_	26	compound	_	_
26	signals	signal	NNS	NNS	_	21	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	30	nsubj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	sufficient	sufficient	JJ	JJ	_	26	acl:relcl	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	lead	lead	VB	VB	_	30	xcomp	_	_
33	to	to	TO	TO	_	37	case	_	_
34	G1	g1	NN	NN	_	37	compound	_	_
35	cell	cell	NN	NN	_	37	compound	_	_
36	cycle	cycle	NN	NN	_	37	compound	_	_
37	progression	progression	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	dep	_	_
3	presence	presence	NN	NN	_	6	dep	_	_
4	of	of	IN	IN	_	6	case	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	alpha,25(OH)2D3	alpha,25(oh)2d3	NN	NN	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	cellular	cellular	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	17	nsubj	_	_
10	associated	associate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	stimulation	stimulation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	such	such	PDT	PDT	_	16	det:predet	_	_
15	a	a	DT	DT	_	16	det	_	_
16	progression	progression	NN	NN	_	12	nmod	_	_
17	appears	appear	VBZ	VBZ	_	0	root	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	sufficient	sufficient	JJ	JJ	_	17	xcomp	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	up-regulation	up-regulation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	VDR	vdr	NN	NN	_	26	compound	_	_
26	message	message	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	protein	protein	NN	NN	_	26	conj	_	_
29	and	and	CC	CC	_	20	cc	_	_
30	necessary	necessary	JJ	JJ	_	20	conj	_	_
31	for	for	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	establishment	establishment	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	VDRE	vdre	NN	NN	_	37	compound	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	complexes	complex	NNS	NNS	_	33	nmod	_	_
38	and	and	CC	CC	_	33	cc	_	_
39	the	the	DT	DT	_	40	det	_	_
40	induction	induction	NN	NN	_	33	conj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	24-hydroxylase	24-hydroxylase	NN	NN	_	43	compound	_	_
43	message	message	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	17	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	biologic	biologic	JJ	JJ	_	4	amod	_	_
4	functions	function	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	aux	_	_
6	modulated	modulate	VBN	VBN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	in	in	IN	IN	_	9	case	_	_
9	that	that	IN	IN	_	12	nmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	hormone	hormone	NN	NN	_	12	nsubj	_	_
12	inhibits	inhibit	VBZ	VBZ	_	6	ccomp	_	_
13	proliferation	proliferation	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	subset	subset	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	reactivity	reactivity	NN	NN	_	11	nsubjpass	_	_
6	to	to	TO	TO	_	8	case	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	alpha,25(OH)2D3	alpha,25(oh)2d3	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	tightly	tightly	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	requiring	require	VBG	VBG	_	11	xcomp	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	signals	signal	NNS	NNS	_	16	dobj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	initiation	initiation	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Cell-type-specific	cell-type-specific	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	human	human	JJ	JJ	_	10	amod	_	_
6	tumor	tumor	NN	NN	_	10	compound	_	_
7	necrosis	necrosis	NN	NN	_	10	compound	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	2	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	by	by	IN	IN	_	18	case	_	_
18	NFATp	nfatp	NN	NN	_	2	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	ATF-2/JUN	atf-2/jun	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	human	human	JJ	JJ	_	10	amod	_	_
3	tumor	tumor	NN	NN	_	6	compound	_	_
4	necrosis	necrosis	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	gene	gene	NN	NN	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	one	one	CD	CD	_	0	root	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	earliest	earliest	JJS	JJS	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	transcribed	transcribe	VBN	VBN	_	16	acl	_	_
18	after	after	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	stimulation	stimulation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cell	cell	NN	NN	_	20	nmod	_	_
25	through	through	IN	IN	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	antigen	antigen	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	20	nmod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	via	via	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	CD-40	cd-40	NN	NN	_	33	compound	_	_
33	pathway	pathway	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	both	both	DT	DT	_	3	det	_	_
3	cases	case	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	induction	induction	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	5	nmod	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	aux	_	_
12	blocked	block	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	immunosuppressants	immunosuppressant	NNS	NNS	_	12	nmod	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	15	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	FK506	fk506	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	12	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	suggested	suggest	VBD	VBD	_	12	ccomp	_	_
23	a	a	DT	DT	_	24	det	_	_
24	role	role	NN	NN	_	22	dobj	_	_
25	for	for	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	NFAT	nfat	NN	NN	_	28	compound	_	_
28	family	family	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	proteins	protein	NNS	NNS	_	28	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	regulation	regulation	NN	NN	_	24	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	gene	gene	NN	NN	_	33	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	B	b	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	33	nmod	_	_
40	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	molecules	molecule	NNS	NNS	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NFATp	nfatp	NN	NN	_	8	nmod	_	_
11	bind	bind	VBP	VBP	_	0	root	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	17	compound	_	_
15	promoter	promoter	NN	NN	_	17	compound	_	_
16	element	element	NN	NN	_	17	compound	_	_
17	kappa	kappa	NN	NN	_	11	nmod	_	_
18	3	3	CD	CD	_	17	nummod	_	_
19	in	in	NN	NN	_	20	dep	_	_
20	association	association	NN	NN	_	11	nmod	_	_
21	with	with	IN	IN	_	25	case	_	_
22	ATF-2	atf-2	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Jun	jun	NN	NN	_	22	conj	_	_
25	proteins	protein	NNS	NNS	_	20	nmod	_	_
26	bound	bind	VBN	VBN	_	25	acl	_	_
27	to	to	TO	TO	_	38	case	_	_
28	an	a	DT	DT	_	38	det	_	_
29	immediately	immediately	RB	RB	_	30	advmod	_	_
30	adjacent	adjacent	JJ	JJ	_	38	amod	_	_
31	cyclic	cyclic	JJ	JJ	_	34	amod	_	_
32	AMP	amp	NN	NN	_	34	compound	_	_
33	response	response	NN	NN	_	34	compound	_	_
34	element	element	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	CRE	cre	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	site	site	NN	NN	_	26	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	using	use	VBG	VBG	_	13	advcl	_	_
4	the	the	DT	DT	_	10	det	_	_
5	murine	murine	JJ	JJ	_	10	amod	_	_
6	B-cell	b-cell	NN	NN	_	10	compound	_	_
7	lymphoma	lymphoma	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	line	line	NN	NN	_	10	compound	_	_
10	A20	a20	NN	NN	_	3	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	show	show	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	the	the	DT	DT	_	17	det	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	regulated	regulate	VBN	VBN	_	13	ccomp	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	cell-type-specific	cell-type-specific	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	A20	a20	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	NFATp	nfatp	NN	NN	_	11	nmod	_	_
14	bound	bind	VBN	VBN	_	13	acl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	3	3	CD	CD	_	19	nummod	_	_
19	element	element	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Instead	instead	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	ATF-2	atf-2	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Jun	jun	NN	NN	_	3	conj	_	_
6	proteins	protein	NNS	NNS	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	0	root	_	_
8	to	to	TO	TO	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	composite	composite	JJ	JJ	_	13	amod	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	3/CRE	3/cre	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	NFATp	nfatp	NN	NN	_	16	nsubj	_	_
16	binds	bind	VBZ	VBZ	_	7	conj	_	_
17	to	to	TO	TO	_	23	case	_	_
18	a	a	DT	DT	_	23	det	_	_
19	newly	newly	RB	RB	_	20	advmod	_	_
20	identified	identify	VBN	VBN	_	23	amod	_	_
21	second	second	JJ	JJ	_	23	amod	_	_
22	NFAT	nfat	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	16	nmod	_	_
24	centered	centered	JJ	JJ	_	23	dep	_	_
25	at	at	IN	IN	_	27	case	_	_
26	-76	-76	CD	CD	_	27	nummod	_	_
27	nucleotides	nucleotide	NNS	NNS	_	24	nmod	_	_
28	relative	relative	JJ	JJ	_	34	case	_	_
29	to	to	TO	TO	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	TNF-alpha	tnf-alpha	NN	NN	_	34	compound	_	_
32	transcription	transcription	NN	NN	_	34	compound	_	_
33	start	start	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	24	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	site	site	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	critical	critical	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	calcium-mediated	calcium-mediated	JJ	JJ	_	14	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	cyclosporin	cyclosporin	NN	NN	_	13	nmod:npmod	_	_
13	A-sensitive	a-sensitive	JJ	JJ	_	10	dep	_	_
14	induction	induction	NN	NN	_	4	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	both	both	CC	CC	_	21	cc:preconj	_	_
19	A20	a20	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Ar-5	ar-5	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	Consistent	consistent	JJ	JJ	_	19	dep	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	19	punct	_	_
6	quantitative	quantitative	JJ	JJ	_	8	amod	_	_
7	DNase	dnase	NN	NN	_	8	compound	_	_
8	footprinting	footprinting	NN	NN	_	19	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	using	use	VBG	VBG	_	8	acl	_	_
14	increasing	increase	VBG	VBG	_	15	amod	_	_
15	amounts	amount	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	recombinant	recombinant	JJ	JJ	_	18	amod	_	_
18	NFATp	nfatp	NN	NN	_	15	nmod	_	_
19	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
20	that	that	IN	IN	_	24	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	-76	-76	CD	CD	_	23	nummod	_	_
23	site	site	NN	NN	_	24	nsubj	_	_
24	binds	bind	VBZ	VBZ	_	19	ccomp	_	_
25	to	to	TO	TO	_	26	case	_	_
26	NFATp	nfatp	NN	NN	_	24	nmod	_	_
27	with	with	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	higher	higher	JJR	JJR	_	30	amod	_	_
30	affinity	affinity	NN	NN	_	24	nmod	_	_
31	than	than	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	kappa	kappa	NN	NN	_	35	compound	_	_
34	3	3	CD	CD	_	35	nummod	_	_
35	site	site	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	19	punct	_	_

1	Two	two	CD	CD	_	6	nummod	_	_
2	other	other	JJ	JJ	_	6	amod	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	unrecognized	unrecognized	JJ	JJ	_	6	amod	_	_
5	NFATp-binding	nfatp-binding	JJ	JJ	_	6	amod	_	_
6	sites	site	NNS	NNS	_	14	nsubjpass	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	proximal	proximal	JJ	JJ	_	11	amod	_	_
10	TNF-alpha	tnf-alpha	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	6	nmod	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	analysis	analysis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	through	through	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	differential	differential	JJ	JJ	_	6	amod	_	_
6	use	use	NN	NN	_	23	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	same	same	JJ	JJ	_	11	amod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	the	the	DT	DT	_	17	det	_	_
14	composite	composite	JJ	JJ	_	17	amod	_	_
15	kappa	kappa	NN	NN	_	17	compound	_	_
16	3/CRE	3/cre	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	11	appos	_	_
18	,	,	,	,	_	23	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	TNF-alpha	tnf-alpha	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	regulated	regulate	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	cell-type-specific	cell-type-specific	JJ	JJ	_	27	amod	_	_
27	manner	manner	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	34	case	_	_
29	response	response	NN	NN	_	34	dep	_	_
30	to	to	TO	TO	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	same	same	JJ	JJ	_	34	amod	_	_
33	extracellular	extracellular	JJ	JJ	_	34	amod	_	_
34	signal	signal	NN	NN	_	23	nmod	_	_
35	.	.	.	.	_	23	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	ligand-binding	ligand-binding	JJ	JJ	_	5	amod	_	_
5	domain	domain	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
9	acid	acid	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	5	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	site-directed	site-directed	JJ	JJ	_	14	amod	_	_
14	mutagenesis	mutagenesis	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	subtypes	subtype	NNS	NNS	_	24	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	retinoic	retinoic	JJ	JJ	_	6	amod	_	_
5	acid	acid	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	RAR	rar	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	2	punct	_	_
11	termed	term	VBN	VBN	_	2	acl	_	_
12	RAR	rar	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	11	xcomp	_	_
14	,	,	,	,	_	13	punct	_	_
15	RAR	rar	NN	NN	_	16	compound	_	_
16	beta	beta	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	RAR	rar	NN	NN	_	20	compound	_	_
20	gamma	gamma	NN	NN	_	13	conj	_	_
21	,	,	,	,	_	2	punct	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	described	describe	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	They	they	PRP	PRP	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	composed	compose	VBN	VBN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	different	different	JJ	JJ	_	7	amod	_	_
6	structural	structural	JJ	JJ	_	7	amod	_	_
7	domains	domain	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	including	include	VBG	VBG	_	11	case	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	domains	domain	NNS	NNS	_	7	nmod	_	_
12	for	for	IN	IN	_	16	case	_	_
13	DNA	dna	NN	NN	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ligand	ligand	NN	NN	_	13	conj	_	_
16	binding	binding	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	RARs	rar	NNS	NNS	_	3	nsubj	_	_
2	specifically	specifically	RB	RB	_	3	advmod	_	_
3	bind	bind	VBP	VBP	_	0	root	_	_
4	all-trans-retinoic	all-trans-retinoic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	3	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	RA	ra	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	9-cis-RA	9-cis-ra	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	retinoid	retinoid	JJ	JJ	_	14	amod	_	_
14	analogs	analog	NNS	NNS	_	5	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	cysteine	cysteine	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	arginine	arginine	NN	NN	_	11	conj	_	_
14	residues	residue	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	ligand-binding	ligand-binding	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	hRAR	hrar	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	hRAR	hrar	NN	NN	_	24	compound	_	_
24	alpha-LBD	alpha-lbd	NN	NN	_	18	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	amino	amino	NN	NN	_	27	compound	_	_
27	acids	acid	NNS	NNS	_	24	appos	_	_
28	154	154	CD	CD	_	27	dep	_	_
29	to	to	TO	TO	_	28	dep	_	_
30	462	462	CD	CD	_	28	dep	_	_
31	)	)	-RRB-	-RRB-	_	24	punct	_	_
32	.	.	.	.	_	6	punct	_	_

1	All	all	DT	DT	_	6	det	_	_
2	conserved	conserve	VBN	VBN	_	6	amod	_	_
3	cysteine	cysteine	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	arginine	arginine	NN	NN	_	3	conj	_	_
6	residues	residue	NNS	NNS	_	11	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	domain	domain	NN	NN	_	6	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	mutated	mutate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	site-directed	site-directed	JJ	JJ	_	14	amod	_	_
14	mutagenesis	mutagenesis	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	mutant	mutant	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	21	nsubjpass	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	characterized	characterize	VBN	VBN	_	11	conj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	blocking	block	VBG	VBG	_	24	amod	_	_
24	reactions	reaction	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	ligand-binding	ligand-binding	JJ	JJ	_	27	amod	_	_
27	experiments	experiment	NNS	NNS	_	24	conj	_	_
28	,	,	,	,	_	24	punct	_	_
29	transactivation	transactivation	NN	NN	_	30	compound	_	_
30	assays	assay	NNS	NNS	_	24	conj	_	_
31	,	,	,	,	_	24	punct	_	_
32	and	and	CC	CC	_	24	cc	_	_
33	protease	protease	NN	NN	_	34	compound	_	_
34	mapping	mapping	NN	NN	_	24	conj	_	_
35	.	.	.	.	_	11	punct	_	_

1	Changes	change	NNS	NNS	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	any	any	DT	DT	_	5	det	_	_
4	cysteine	cysteine	JJ	JJ	_	5	amod	_	_
5	residue	residue	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	hRAR	hrar	NN	NN	_	9	compound	_	_
9	alpha-LBD	alpha-lbd	NN	NN	_	5	nmod	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	no	no	DT	DT	_	13	neg	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	influence	influence	NN	NN	_	10	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	binding	binding	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	all-trans	all-trans	JJ	JJ	_	19	amod	_	_
19	RA	ra	NN	NN	_	16	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	9-cis	9-cis	JJ	JJ	_	22	amod	_	_
22	RA	ra	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	Interestingly	interestingly	RB	RB	_	7	nsubj	_	_
2	,	,	,	,	_	7	punct	_	_
3	residue	residue	JJ	JJ	_	4	amod	_	_
4	C-235	c-235	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	important	important	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	antagonist	antagonist	NN	NN	_	10	compound	_	_
10	binding	binding	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	With	with	IN	IN	_	5	case	_	_
2	respect	respect	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	arginine	arginine	NN	NN	_	5	compound	_	_
5	residues	residue	NNS	NNS	_	18	nmod	_	_
6	,	,	,	,	_	18	punct	_	_
7	only	only	RB	RB	_	11	advmod	_	_
8	the	the	DT	DT	_	11	det	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	single	single	JJ	JJ	_	11	amod	_	_
11	mutations	mutation	NNS	NNS	_	18	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	R-276	r-276	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	R-394	r-394	NN	NN	_	13	conj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	alanine	alanine	NN	NN	_	11	nmod	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	21	det	_	_
20	dramatic	dramatic	JJ	JJ	_	21	amod	_	_
21	decrease	decrease	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	agonist	agonist	NN	NN	_	26	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	antagonist	antagonist	NN	NN	_	23	conj	_	_
26	binding	binding	NN	NN	_	21	nmod	_	_
27	whereas	whereas	IN	IN	_	31	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	R272A	r272a	NN	NN	_	30	compound	_	_
30	mutation	mutation	NN	NN	_	31	nsubj	_	_
31	showed	show	VBD	VBD	_	18	advcl	_	_
32	only	only	RB	RB	_	35	advmod	_	_
33	a	a	DT	DT	_	35	det	_	_
34	slight	slight	JJ	JJ	_	35	amod	_	_
35	effect	effect	NN	NN	_	31	dobj	_	_
36	.	.	.	.	_	18	punct	_	_

1	For	for	IN	IN	_	5	case	_	_
2	all	all	DT	DT	_	5	det	_	_
3	other	other	JJ	JJ	_	5	amod	_	_
4	arginine	arginine	NN	NN	_	5	compound	_	_
5	mutations	mutation	NNS	NNS	_	12	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	differences	difference	NNS	NNS	_	12	nsubj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	affinity	affinity	NN	NN	_	8	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	detectable	detectable	JJ	JJ	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
4	R217A	r217a	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	R294A	r294a	NN	NN	_	4	conj	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	an	a	DT	DT	_	11	det	_	_
9	increased	increase	VBN	VBN	_	11	amod	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	efficiency	efficiency	NN	NN	_	7	dobj	_	_
12	for	for	IN	IN	_	13	case	_	_
13	antagonists	antagonist	NNS	NNS	_	11	nmod	_	_
14	but	but	CC	CC	_	11	cc	_	_
15	no	no	DT	DT	_	16	neg	_	_
16	change	change	NN	NN	_	11	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	agonist	agonist	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	results	result	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	conclude	conclude	VB	VB	_	0	root	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	electrostatic	electrostatic	JJ	JJ	_	10	amod	_	_
10	interactions	interaction	NNS	NNS	_	17	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	retinoids	retinoid	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	RAR	rar	NN	NN	_	16	compound	_	_
16	alpha-LBD	alpha-lbd	NN	NN	_	10	nmod	_	_
17	play	play	VBP	VBP	_	7	ccomp	_	_
18	a	a	DT	DT	_	20	det	_	_
19	significant	significant	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	ligand	ligand	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	antagonists	antagonist	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	distinctly	distinctly	RB	RB	_	7	advmod	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	requirements	requirement	NNS	NNS	_	5	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	efficient	efficient	JJ	JJ	_	11	amod	_	_
11	binding	binding	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	contribute	contribute	VB	VB	_	8	acl:relcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	interference	interference	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	ligand-inducible	ligand-inducible	JJ	JJ	_	23	amod	_	_
22	transactivation	transactivation	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	RAR	rar	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	beta	beta	NN	NN	_	7	compound	_	_
7	subunit	subunit	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	proximal	proximal	JJ	JJ	_	12	amod	_	_
11	sequence	sequence	NN	NN	_	12	nmod:npmod	_	_
12	element-binding	element-binding	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	1	cc	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	involvement	involvement	NN	NN	_	1	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	transcription	transcription	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	small	small	JJ	JJ	_	24	amod	_	_
22	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
23	RNA	rna	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	19	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	RNA	rna	NN	NN	_	27	compound	_	_
27	polymerases	polymerase	NNS	NNS	_	19	nmod	_	_
28	II	ii	CD	CD	_	27	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	III	iii	CD	CD	_	28	conj	_	_
31	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	proximal	proximal	JJ	JJ	_	4	amod	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	element	element	NN	NN	_	8	dep	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	PSE	pse	NN	NN	_	8	nmod:npmod	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	-binding	-binding	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	38	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PTF	ptf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	10	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	binds	bind	VBZ	VBZ	_	10	acl:relcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	PSE	pse	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	35	case	_	_
20	both	both	CC	CC	_	23	cc:preconj	_	_
21	RNA	rna	NN	NN	_	23	compound	_	_
22	polymerase	polymerase	NN	NN	_	23	compound	_	_
23	II-	ii-	NN	NN	_	35	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	RNA	rna	NN	NN	_	27	nmod:npmod	_	_
26	polymerase	polymerase	NN	NN	_	27	nmod:npmod	_	_
27	III-transcribed	iii-transcribed	JJ	JJ	_	23	conj	_	_
28	mammalian	mammalian	JJ	JJ	_	35	amod	_	_
29	small	small	JJ	JJ	_	31	amod	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	RNA	rna	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	snRNA	snrna	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	genes	gene	NNS	NNS	_	18	nmod	_	_
36	,	,	,	,	_	10	punct	_	_
37	is	be	VBZ	VBZ	_	38	cop	_	_
38	essential	essential	JJ	JJ	_	0	root	_	_
39	for	for	IN	IN	_	41	case	_	_
40	their	they	PRP$	PRP$	_	41	nmod:poss	_	_
41	transcription	transcription	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	38	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	purification	purification	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	PTF	ptf	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	complex	complex	NN	NN	_	8	appos	_	_
12	of	of	IN	IN	_	14	case	_	_
13	four	four	CD	CD	_	14	nummod	_	_
14	subunits	subunit	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	molecular	molecular	JJ	JJ	_	19	amod	_	_
19	cloning	cloning	NN	NN	_	5	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	characterization	characterization	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	PTF	ptf	NN	NN	_	27	compound	_	_
24	gamma	gamma	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	delta	delta	NN	NN	_	24	conj	_	_
27	subunits	subunit	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	isolation	isolation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	expression	expression	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	cDNA	cdna	NN	NN	_	5	nmod	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	PTF	ptf	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	5	punct	_	_
15	as	as	RB	RB	_	5	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	studies	study	NNS	NNS	_	5	conj	_	_
20	using	use	VBG	VBG	_	19	acl	_	_
21	anti-PTF	anti-ptf	JJ	JJ	_	22	dep	_	_
22	beta	beta	NN	NN	_	23	amod	_	_
23	antibodies	antibody	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Native	native	JJ	JJ	_	3	amod	_	_
2	PTF	ptf	NN	NN	_	3	compound	_	_
3	beta	beta	NN	NN	_	16	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	8	case	_	_
6	either	either	CC	CC	_	8	cc:preconj	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	fractions	fraction	NNS	NNS	_	3	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	12	det	_	_
11	PTF-Oct-1-DNA	ptf-oct-1-dna	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	recognized	recognize	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	polyclonal	polyclonal	JJ	JJ	_	19	amod	_	_
19	antibodies	antibody	NNS	NNS	_	16	nmod	_	_
20	raised	raise	VBN	VBN	_	19	acl	_	_
21	against	against	IN	IN	_	24	case	_	_
22	recombinant	recombinant	JJ	JJ	_	24	amod	_	_
23	PTF	ptf	NN	NN	_	24	compound	_	_
24	beta	beta	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Immunodepletion	immunodepletion	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	PTF	ptf	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	3	ccomp	_	_
9	for	for	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	both	both	DT	DT	_	13	det	_	_
13	classes	class	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	snRNA	snrna	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	10	advmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	immunoprecipitation	immunoprecipitation	NN	NN	_	5	compound	_	_
5	analyses	analysis	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	23	mark	_	_
8	substantial	substantial	JJ	JJ	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	similar	similar	JJ	JJ	_	8	conj	_	_
11	molar	molar	JJ	JJ	_	12	amod	_	_
12	amounts	amount	NNS	NNS	_	23	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TATA-binding	tata-binding	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TBP	tbp	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	TFIIIB90	tfiiib90	NN	NN	_	15	conj	_	_
21	can	can	MD	MD	_	23	aux	_	_
22	weakly	weakly	RB	RB	_	23	advmod	_	_
23	associate	associate	VBP	VBP	_	6	ccomp	_	_
24	with	with	IN	IN	_	25	case	_	_
25	PTF	ptf	NN	NN	_	23	nmod	_	_
26	at	at	IN	IN	_	29	case	_	_
27	low	low	JJ	JJ	_	29	amod	_	_
28	salt	salt	NN	NN	_	29	compound	_	_
29	conditions	condition	NNS	NNS	_	23	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	but	but	CC	CC	_	23	cc	_	_
32	this	this	DT	DT	_	33	det	_	_
33	association	association	NN	NN	_	36	nsubjpass	_	_
34	is	be	VBZ	VBZ	_	36	auxpass	_	_
35	dramatically	dramatically	RB	RB	_	36	advmod	_	_
36	reduced	reduce	VBN	VBN	_	23	conj	_	_
37	at	at	IN	IN	_	40	case	_	_
38	high	high	JJ	JJ	_	40	amod	_	_
39	salt	salt	NN	NN	_	40	compound	_	_
40	concentrations	concentration	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Along	along	IN	IN	_	5	case	_	_
2	with	with	IN	IN	_	5	case	_	_
3	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
4	previous	previous	JJ	JJ	_	5	amod	_	_
5	demonstration	demonstration	NN	NN	_	35	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	both	both	DT	DT	_	9	det	_	_
8	physical	physical	JJ	JJ	_	9	amod	_	_
9	interactions	interaction	NNS	NNS	_	5	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	PTF	ptf	NN	NN	_	12	compound	_	_
12	gamma	gamma	NN	NN	_	9	nmod	_	_
13	/	/	:	:	_	12	punct	_	_
14	PTF	ptf	NN	NN	_	15	compound	_	_
15	delta	delta	NN	NN	_	12	dep	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	TBP	tbp	NN	NN	_	12	conj	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	involvement	involvement	NN	NN	_	9	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	TFIIIB90	tfiiib90	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	transcription	transcription	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	class	class	NN	NN	_	30	compound	_	_
28	III	iii	CD	CD	_	30	nummod	_	_
29	snRNA	snrna	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	25	nmod	_	_
31	,	,	,	,	_	35	punct	_	_
32	these	these	DT	DT	_	33	det	_	_
33	results	result	NNS	NNS	_	35	nsubj	_	_
34	are	be	VBP	VBP	_	35	cop	_	_
35	consistent	consistent	JJ	JJ	_	0	root	_	_
36	with	with	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	notion	notion	NN	NN	_	35	nmod	_	_
39	that	that	IN	IN	_	47	mark	_	_
40	a	a	DT	DT	_	42	det	_	_
41	TBP-containing	tbp-containing	JJ	JJ	_	42	amod	_	_
42	complex	complex	NN	NN	_	47	nsubjpass	_	_
43	related	related	JJ	JJ	_	42	amod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	TFIIIB	tfiiib	NN	NN	_	43	nmod	_	_
46	is	be	VBZ	VBZ	_	47	auxpass	_	_
47	required	require	VBN	VBN	_	38	ccomp	_	_
48	for	for	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	transcription	transcription	NN	NN	_	47	nmod	_	_
51	of	of	IN	IN	_	55	case	_	_
52	class	class	NN	NN	_	55	compound	_	_
53	III	iii	CD	CD	_	55	nummod	_	_
54	snRNA	snrna	NN	NN	_	55	compound	_	_
55	genes	gene	NNS	NNS	_	50	nmod	_	_
56	,	,	,	,	_	47	punct	_	_
57	and	and	CC	CC	_	47	cc	_	_
58	acts	act	VBZ	VBZ	_	47	conj	_	_
59	through	through	IN	IN	_	61	case	_	_
60	weak	weak	JJ	JJ	_	61	amod	_	_
61	interaction	interaction	NN	NN	_	58	nmod	_	_
62	with	with	IN	IN	_	65	case	_	_
63	the	the	DT	DT	_	65	det	_	_
64	four-subunit	four-subunit	JJ	JJ	_	65	amod	_	_
65	PTF	ptf	NN	NN	_	61	nmod	_	_
66	.	.	.	.	_	35	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	bcl-2	bcl-2	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	phosphorylated	phosphorylate	VBN	VBN	_	8	amod	_	_
7	CREB	creb	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	1	nmod	_	_
9	during	during	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	1	nmod	_	_
12	and	and	CC	CC	_	1	cc	_	_
13	rescue	rescue	NN	NN	_	1	conj	_	_
14	from	from	IN	IN	_	15	case	_	_
15	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Engagement	engagement	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	surface	surface	NN	NN	_	4	compound	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	mature	mature	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	leads	lead	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	rescue	rescue	NN	NN	_	9	nmod	_	_
12	from	from	IN	IN	_	13	case	_	_
13	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	to	to	TO	TO	_	16	case	_	_
16	proliferation	proliferation	NN	NN	_	11	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	Levels	level	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	bcl-2	bcl-2	NN	NN	_	1	nmod	_	_
4	mRNA	mrna	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	protein	protein	NN	NN	_	4	conj	_	_
7	increase	increase	VBP	VBP	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	cross-linking	cross-linking	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	surface	surface	NN	NN	_	12	compound	_	_
12	immunoglobulin	immunoglobulin	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	located	located	JJ	JJ	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	major	major	JJ	JJ	_	8	amod	_	_
6	positive	positive	JJ	JJ	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	3	dobj	_	_
9	for	for	IN	IN	_	10	case	_	_
10	control	control	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	bcl-2	bcl-2	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	5'-flanking	5'-flanking	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	3	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	positive	positive	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	6	nsubjpass	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	divided	divide	VBN	VBN	_	0	root	_	_
7	into	into	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	upstream	upstream	JJ	JJ	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	downstream	downstream	JJ	JJ	_	9	conj	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	region	region	NN	NN	_	9	dep	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	downstream	downstream	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	cyclic	cyclic	JJ	JJ	_	8	amod	_	_
8	AMP-responsive	amp-responsive	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	5	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CRE	cre	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	by	by	IN	IN	_	6	case	_	_
4	antibody	antibody	NN	NN	_	6	compound	_	_
5	supershift	supershift	NN	NN	_	6	compound	_	_
6	experiments	experiment	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	UV	uv	NN	NN	_	9	compound	_	_
9	cross-linking	cross-linking	NN	NN	_	6	conj	_	_
10	followed	follow	VBN	VBN	_	6	acl	_	_
11	by	by	IN	IN	_	15	case	_	_
12	denaturing	denature	VBG	VBG	_	15	amod	_	_
13	polyacrylamide	polyacrylamide	NN	NN	_	15	compound	_	_
14	gel	gel	NN	NN	_	15	compound	_	_
15	electrophoresis	electrophoresis	NN	NN	_	10	nmod	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	CREB	creb	NN	NN	_	22	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	ATF	atf	NN	NN	_	18	conj	_	_
21	family	family	NN	NN	_	22	compound	_	_
22	members	member	NNS	NNS	_	23	nsubj	_	_
23	bind	bind	VBP	VBP	_	2	ccomp	_	_
24	to	to	TO	TO	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	region	region	NN	NN	_	23	nmod	_	_
27	in	in	FW	FW	_	28	compound	_	_
28	vitro	vitro	FW	FW	_	23	advmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Mutations	mutation	NNS	NNS	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CRE	cre	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	result	result	VBP	VBP	_	1	acl:relcl	_	_
8	in	in	IN	IN	_	9	case	_	_
9	loss	loss	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CREB	creb	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	lead	lead	VBP	VBP	_	0	root	_	_
15	to	to	TO	TO	_	16	case	_	_
16	loss	loss	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	bcl-2	bcl-2	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	transient-transfection	transient-transfection	NN	NN	_	26	compound	_	_
26	assays	assay	NNS	NNS	_	14	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	an	a	DT	DT	_	7	det	_	_
5	active	active	JJ	JJ	_	7	amod	_	_
6	CRE	cre	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	bcl-2	bcl-2	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	2	nmod	_	_
12	implies	imply	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	regulation	regulation	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	bcl-2	bcl-2	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	linked	link	VBN	VBN	_	12	ccomp	_	_
21	to	to	TO	TO	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	signal	signal	NN	NN	_	25	compound	_	_
24	transduction	transduction	NN	NN	_	25	compound	_	_
25	pathway	pathway	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Treatment	treatment	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	mature	mature	JJ	JJ	_	7	amod	_	_
5	B-cell	b-cell	NN	NN	_	7	compound	_	_
6	line	line	NN	NN	_	7	compound	_	_
7	BAL-17	bal-17	NN	NN	_	1	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	either	either	CC	CC	_	11	cc:preconj	_	_
10	anti-immunoglobulin	anti-immunoglobulin	JJ	JJ	_	11	amod	_	_
11	M	m	NN	NN	_	1	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	phorbol	phorbol	NN	NN	_	15	compound	_	_
14	12-myristate	12-myristate	NN	NN	_	15	compound	_	_
15	13-acetate	13-acetate	NN	NN	_	11	conj	_	_
16	leads	lead	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	increase	increase	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	bcl-2	bcl-2	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	mediated	mediate	VBN	VBN	_	22	acl:relcl	_	_
26	by	by	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	CRE	cre	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	more	more	RBR	RBR	_	5	advmod	_	_
5	immature	immature	JJ	JJ	_	7	amod	_	_
6	B-cell	b-cell	NN	NN	_	7	compound	_	_
7	line	line	NN	NN	_	1	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	Ramos	ramos	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	with	with	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	esters	ester	NNS	NNS	_	1	nmod	_	_
14	rescues	rescue	VBZ	VBZ	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	14	dobj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	calcium-dependent	calcium-dependent	JJ	JJ	_	19	amod	_	_
19	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	bcl-2	bcl-2	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	increased	increase	VBN	VBN	_	0	root	_	_
5	following	follow	VBG	VBG	_	8	case	_	_
6	phorbol	phorbol	NN	NN	_	8	compound	_	_
7	ester	ester	NN	NN	_	8	compound	_	_
8	treatment	treatment	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	expression	expression	NN	NN	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	4	conj	_	_
16	on	on	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CRE	cre	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	stimuli	stimulus	NNS	NNS	_	3	nsubj	_	_
3	result	result	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	phosphorylation	phosphorylation	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CREB	creb	NN	NN	_	5	nmod	_	_
8	at	at	IN	IN	_	9	case	_	_
9	serine	serine	NN	NN	_	5	nmod	_	_
10	133	133	CD	CD	_	9	nummod	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	phosphorylation	phosphorylation	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CREB	creb	NN	NN	_	2	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	results	result	VBZ	VBZ	_	2	acl:relcl	_	_
7	in	in	IN	IN	_	8	case	_	_
8	activation	activation	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	C	c	NN	NN	_	10	nmod	_	_
15	rather	rather	RB	RB	_	14	cc	_	_
16	than	than	IN	IN	_	15	mwe	_	_
17	by	by	IN	IN	_	20	case	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	CRE	cre	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	necessary	necessary	JJ	JJ	_	13	advcl	_	_
7	,	,	,	,	_	13	punct	_	_
8	optimal	optimal	JJ	JJ	_	9	amod	_	_
9	induction	induction	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	bcl-2	bcl-2	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	requires	require	VBZ	VBZ	_	0	root	_	_
14	participation	participation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	upstream	upstream	JJ	JJ	_	19	amod	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	element	element	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	suggesting	suggest	VBG	VBG	_	13	advcl	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	phosphorylation	phosphorylation	NN	NN	_	26	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	CREB	creb	NN	NN	_	23	nmod	_	_
26	alters	alter	VBZ	VBZ	_	21	ccomp	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	interaction	interaction	NN	NN	_	26	dobj	_	_
29	with	with	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	upstream	upstream	JJ	JJ	_	33	amod	_	_
32	regulatory	regulatory	JJ	JJ	_	33	amod	_	_
33	element	element	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CRE	cre	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	8	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	bcl-2	bcl-2	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	appears	appear	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	major	major	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	bcl-2	bcl-2	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	during	during	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activation	activation	NN	NN	_	10	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	mature	mature	JJ	JJ	_	26	amod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	during	during	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	rescue	rescue	NN	NN	_	22	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	immature	immature	JJ	JJ	_	34	amod	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	from	from	IN	IN	_	36	case	_	_
36	apoptosis	apoptosis	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	possible	possible	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CRE	cre	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
10	for	for	IN	IN	_	11	case	_	_
11	induction	induction	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	bcl-2	bcl-2	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	particularly	particularly	RB	RB	_	21	advmod	_	_
21	those	those	DT	DT	_	18	appos	_	_
22	in	in	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	28	nmod	_	_
24	protein	protein	NN	NN	_	26	compound	_	_
25	kinase	kinase	NN	NN	_	26	compound	_	_
26	C	c	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	involved	involve	VBN	VBN	_	21	acl:relcl	_	_
29	.	.	.	.	_	3	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	2	nsubj	_	_
2	promotes	promote	VBZ	VBZ	_	0	root	_	_
3	multiple	multiple	JJ	JJ	_	6	amod	_	_
4	myeloma	myeloma	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	growth	growth	NN	NN	_	2	dobj	_	_
7	via	via	IN	IN	_	8	case	_	_
8	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	retinoblastoma	retinoblastoma	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-6	il-6	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	mediates	mediate	VBZ	VBZ	_	0	root	_	_
6	autocrine	autocrine	NN	NN	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	paracrine	paracrine	NN	NN	_	6	conj	_	_
9	growth	growth	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	multiple	multiple	JJ	JJ	_	12	amod	_	_
12	myeloma	myeloma	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	MM	mm	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	inhibits	inhibit	VBZ	VBZ	_	5	conj	_	_
19	tumor	tumor	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	apoptosis	apoptosis	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	5	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	retinoblastoma	retinoblastoma	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	pRB	prb	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	mutations	mutation	NNS	NNS	_	1	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	RB	rb	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	9	nmod	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	reported	report	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	up	up	IN	IN	_	19	dep	_	_
18	to	to	TO	TO	_	17	mwe	_	_
19	70	70	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	MM	mm	NN	NN	_	23	compound	_	_
23	patients	patient	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	80	80	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	20	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	MM-derived	mm-derived	JJ	JJ	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	dephosphorylated	dephosphorylate	VBN	VBN	_	6	amod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	activated	activate	VBN	VBN	_	2	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	pRB	prb	NN	NN	_	7	nsubj	_	_
7	blocks	block	VBZ	VBZ	_	30	advcl	_	_
8	transition	transition	NN	NN	_	7	dobj	_	_
9	from	from	IN	IN	_	10	case	_	_
10	G1	g1	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	S	s	NN	NN	_	8	nmod	_	_
13	phase	phase	NN	NN	_	8	dep	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	cycle	cycle	NN	NN	_	8	nmod	_	_
18	whereas	whereas	IN	IN	_	7	dep	_	_
19	phosphorylated	phosphorylate	VBN	VBN	_	23	amod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	inactivated	inactivate	VBN	VBN	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	pRB	prb	NN	NN	_	24	nsubj	_	_
24	releases	release	VBZ	VBZ	_	7	parataxis	_	_
25	this	this	DT	DT	_	27	det	_	_
26	growth	growth	NN	NN	_	27	compound	_	_
27	arrest	arrest	NN	NN	_	24	dobj	_	_
28	,	,	,	,	_	30	punct	_	_
29	we	we	PRP	PRP	_	30	nsubj	_	_
30	characterized	characterize	VBD	VBD	_	0	root	_	_
31	the	the	DT	DT	_	32	det	_	_
32	role	role	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	pRB	prb	NN	NN	_	32	nmod	_	_
35	in	in	IN	IN	_	39	case	_	_
36	IL-6-mediated	il-6-mediated	JJ	JJ	_	39	amod	_	_
37	MM	mm	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	growth	growth	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	30	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	phosphorylated	phosphorylate	VBN	VBN	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	dephosphorylated	dephosphorylate	VBN	VBN	_	2	conj	_	_
5	pRB	prb	NN	NN	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	all	all	DT	DT	_	13	det	_	_
10	serum-starved	serum-starved	JJ	JJ	_	13	amod	_	_
11	MM	mm	NN	NN	_	13	compound	_	_
12	patient	patient	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	MM-derived	mm-derived	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	but	but	CC	CC	_	7	cc	_	_
20	pRB	prb	NN	NN	_	26	nsubj	_	_
21	was	be	VBD	VBD	_	26	cop	_	_
22	predominantly	predominantly	RB	RB	_	26	advmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	phosphorylated	phosphorylated	JJ	JJ	_	26	amod	_	_
26	form	form	NN	NN	_	7	conj	_	_
27	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	MM	mm	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	13	nmod	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	proliferated	proliferate	VBD	VBD	_	3	acl:relcl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	response	response	NN	NN	_	9	dep	_	_
8	to	to	TO	TO	_	9	case	_	_
9	IL-6	il-6	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	exogenous	exogenous	JJ	JJ	_	12	amod	_	_
12	IL-6	il-6	NN	NN	_	13	nsubj	_	_
13	downregulated	downregulate	VBD	VBD	_	0	root	_	_
14	dephosphorylated	dephosphorylate	VBN	VBN	_	15	amod	_	_
15	pRB	prb	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	decreased	decrease	VBD	VBD	_	13	conj	_	_
18	dephosphorylated	dephosphorylate	VBN	VBN	_	20	amod	_	_
19	pRB-E2F	prb-e2f	NN	NN	_	20	compound	_	_
20	complexes	complex	NNS	NNS	_	17	dobj	_	_
21	.	.	.	.	_	13	punct	_	_

1	Importantly	importantly	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	culture	culture	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	MM	mm	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	16	case	_	_
8	RB	rb	NN	NN	_	9	nmod:npmod	_	_
9	antisense	antisense	JJ	JJ	_	16	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	9	cc	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	RB	rb	NN	NN	_	14	dep	_	_
14	sense	sense	NN	NN	_	9	conj	_	_
15	,	,	,	,	_	9	punct	_	_
16	oligonucleotide	oligonucleotide	NN	NN	_	6	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ODN	odn	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	triggered	trigger	VBD	VBD	_	0	root	_	_
21	IL-6	il-6	NN	NN	_	20	dobj	_	_
22	secretion	secretion	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	proliferation	proliferation	NN	NN	_	22	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	MM	mm	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	21	nmod	_	_
28	;	;	:	:	_	20	punct	_	_
29	however	however	RB	RB	_	35	advmod	_	_
30	,	,	,	,	_	35	punct	_	_
31	proliferation	proliferation	NN	NN	_	35	nsubjpass	_	_
32	was	be	VBD	VBD	_	35	auxpass	_	_
33	only	only	RB	RB	_	34	advmod	_	_
34	partially	partially	RB	RB	_	35	advmod	_	_
35	inhibited	inhibit	VBN	VBN	_	20	parataxis	_	_
36	by	by	IN	IN	_	37	mark	_	_
37	neutralizing	neutralize	VBG	VBG	_	35	advcl	_	_
38	anti-IL-6	anti-il-6	JJ	JJ	_	40	amod	_	_
39	monoclonal	monoclonal	JJ	JJ	_	40	amod	_	_
40	antibody	antibody	NN	NN	_	37	dobj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	MoAb	moab	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	35	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	MM	mm	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	normal	normal	JJ	JJ	_	10	amod	_	_
8	splenic	splenic	JJ	JJ	_	10	amod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	11	nsubj	_	_
11	express	express	VBP	VBP	_	0	root	_	_
12	dephosphorylated	dephosphorylate	VBN	VBN	_	13	amod	_	_
13	pRB	prb	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	CD40	cd40	NN	NN	_	3	compound	_	_
3	ligand	ligand	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	CD40L	cd40l	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	triggers	trigger	VBZ	VBZ	_	32	advcl	_	_
8	a	a	DT	DT	_	9	det	_	_
9	shift	shift	NN	NN	_	7	dobj	_	_
10	from	from	IN	IN	_	11	case	_	_
11	dephosphorylated	dephosphorylate	VBN	VBN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	phosphorylated	phosphorylate	VBN	VBN	_	9	nmod	_	_
14	pRB	prb	NN	NN	_	9	dep	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	proliferation	proliferation	NN	NN	_	9	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	32	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	addition	addition	NN	NN	_	32	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	exogenous	exogenous	JJ	JJ	_	25	amod	_	_
25	IL-6	il-6	NN	NN	_	22	nmod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	CD40L-treated	cd40l-treated	JJ	JJ	_	29	amod	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	nmod	_	_
30	does	do	VBZ	VBZ	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	alter	alter	VB	VB	_	0	root	_	_
33	either	either	CC	CC	_	34	cc:preconj	_	_
34	pRB	prb	NN	NN	_	32	dobj	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	proliferation	proliferation	NN	NN	_	34	conj	_	_
37	,	,	,	,	_	32	punct	_	_
38	as	as	IN	IN	_	39	mark	_	_
39	observed	observe	VBN	VBN	_	32	advcl	_	_
40	in	in	IN	IN	_	42	case	_	_
41	MM	mm	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	32	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	phosphorylated	phosphorylate	VBN	VBN	_	6	amod	_	_
6	pRB	prb	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	MM	mm	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	IL-6	il-6	NN	NN	_	17	nsubj	_	_
16	further	further	RB	RB	_	17	advmod	_	_
17	shifts	shift	VBZ	VBZ	_	9	conj	_	_
18	pRB	prb	NN	NN	_	17	dobj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	dephosphorylated	dephosphorylated	JJ	JJ	_	17	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	phosphorylated	phosphorylated	JJ	JJ	_	17	nmod	_	_
25	form	form	NN	NN	_	17	dobj	_	_
26	,	,	,	,	_	17	punct	_	_
27	thereby	thereby	RB	RB	_	28	advmod	_	_
28	promoting	promote	VBG	VBG	_	17	advcl	_	_
29	MM	mm	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	growth	growth	NN	NN	_	28	dobj	_	_
32	via	via	IN	IN	_	34	case	_	_
33	two	two	CD	CD	_	34	nummod	_	_
34	mechanisms	mechanism	NNS	NNS	_	28	nmod	_	_
35	;	;	:	:	_	34	punct	_	_
36	by	by	IN	IN	_	37	mark	_	_
37	decreasing	decrease	VBG	VBG	_	34	acl	_	_
38	the	the	DT	DT	_	39	det	_	_
39	amount	amount	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	E2F	e2f	NN	NN	_	39	nmod	_	_
42	bound	bind	VBN	VBN	_	41	acl	_	_
43	by	by	IN	IN	_	45	case	_	_
44	dephosphorylated	dephosphorylate	VBN	VBN	_	45	amod	_	_
45	pRB	prb	NN	NN	_	42	nmod	_	_
46	due	due	IN	IN	_	50	case	_	_
47	to	to	TO	TO	_	46	mwe	_	_
48	reduced	reduce	VBN	VBN	_	50	amod	_	_
49	dephosphorylated	dephosphorylate	VBN	VBN	_	50	amod	_	_
50	pRB	prb	NN	NN	_	37	nmod	_	_
51	,	,	,	,	_	37	punct	_	_
52	thereby	thereby	RB	RB	_	53	advmod	_	_
53	releasing	release	VBG	VBG	_	37	advcl	_	_
54	growth	growth	NN	NN	_	55	compound	_	_
55	arrest	arrest	NN	NN	_	53	dobj	_	_
56	;	;	:	:	_	37	punct	_	_
57	and	and	CC	CC	_	37	cc	_	_
58	by	by	IN	IN	_	59	mark	_	_
59	upregulating	upregulate	VBG	VBG	_	37	conj	_	_
60	IL-6	il-6	NN	NN	_	61	compound	_	_
61	secretion	secretion	NN	NN	_	59	dobj	_	_
62	by	by	IN	IN	_	64	case	_	_
63	MM	mm	NN	NN	_	64	compound	_	_
64	cells	cell	NNS	NNS	_	61	nmod	_	_
65	and	and	CC	CC	_	61	cc	_	_
66	related	related	JJ	JJ	_	71	amod	_	_
67	IL-6-mediated	il-6-mediated	JJ	JJ	_	71	amod	_	_
68	autocrine	autocrine	JJ	JJ	_	71	amod	_	_
69	tumor	tumor	NN	NN	_	71	compound	_	_
70	cell	cell	NN	NN	_	71	compound	_	_
71	growth	growth	NN	NN	_	61	conj	_	_
72	.	.	.	.	_	3	punct	_	_

1	JNK	jnk	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	5	punct	_	_
3	c-Jun	c-jun	NN	NN	_	5	compound	_	_
4	NH2-terminal	nh2-terminal	JJ	JJ	_	5	amod	_	_
5	kinase	kinase	NN	NN	_	1	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	target	target	NN	NN	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	antioxidants	antioxidant	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	AP-1	ap-1	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	behave	behave	VB	VB	_	4	xcomp	_	_
7	as	as	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	redox-sensitive	redox-sensitive	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	that	that	WDT	WDT	_	15	nsubjpass	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	11	acl:relcl	_	_
16	by	by	IN	IN	_	21	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	oxidant	oxidant	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	antioxidant	antioxidant	JJ	JJ	_	18	conj	_	_
21	stimuli	stimulus	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	15	nsubj	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	AP-1	ap-1	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	antioxidants	antioxidant	NNS	NNS	_	8	nmod	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	largely	largely	RB	RB	_	15	advmod	_	_
15	unknown	unknown	JJ	JJ	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	23	mark	_	_
7	the	the	DT	DT	_	11	det	_	_
8	structurally	structurally	RB	RB	_	9	advmod	_	_
9	unrelated	unrelated	JJ	JJ	_	11	amod	_	_
10	antioxidant	antioxidant	JJ	JJ	_	11	amod	_	_
11	agents	agent	NNS	NNS	_	23	nsubj	_	_
12	pyrrolidine	pyrrolidine	NN	NN	_	13	compound	_	_
13	dithiocarbamate	dithiocarbamate	NN	NN	_	11	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PDTC	pdtc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	butylated	butylate	VBN	VBN	_	19	amod	_	_
19	hydroxyanisole	hydroxyanisole	NN	NN	_	13	conj	_	_
20	,	,	,	,	_	13	punct	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	Nacetylcysteine	nacetylcysteine	NN	NN	_	13	conj	_	_
23	activated	activate	VBD	VBD	_	5	ccomp	_	_
24	JNK	jnk	NN	NN	_	23	dobj	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	c-Jun	c-jun	NN	NN	_	28	compound	_	_
27	NH2-terminal	nh2-terminal	JJ	JJ	_	28	amod	_	_
28	kinase	kinase	NN	NN	_	24	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	in	in	IN	IN	_	33	case	_	_
31	Jurkat	jurkat	NN	NN	_	33	compound	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	23	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	differed	differ	VBD	VBD	_	0	root	_	_
4	substantially	substantially	RB	RB	_	3	advmod	_	_
5	from	from	IN	IN	_	6	case	_	_
6	that	that	DT	DT	_	3	nmod	_	_
7	mediated	mediate	VBN	VBN	_	6	dep	_	_
8	by	by	IN	IN	_	11	case	_	_
9	phorbol	phorbol	NN	NN	_	11	compound	_	_
10	12-myristate	12-myristate	NN	NN	_	11	compound	_	_
11	13-acetate	13-acetate	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PMA	pma	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	Ca2+	ca2+	NN	NN	_	17	compound	_	_
17	ionophore	ionophore	NN	NN	_	11	conj	_	_
18	or	or	CC	CC	_	7	cc	_	_
19	produced	produce	VBN	VBN	_	7	conj	_	_
20	by	by	IN	IN	_	21	case	_	_
21	costimulation	costimulation	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	antibodies	antibody	NNS	NNS	_	21	nmod	_	_
24	against	against	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	T	t	NN	NN	_	28	dep	_	_
27	cell	cell	NN	NN	_	28	dep	_	_
28	receptor-CD3	receptor-cd3	NN	NN	_	29	amod	_	_
29	complex	complex	NN	NN	_	23	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	to	to	TO	TO	_	29	conj	_	_
32	CD28	cd28	NN	NN	_	29	dep	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	JNK	jnk	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	9	case	_	_
6	classical	classical	JJ	JJ	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	stimuli	stimulus	NNS	NNS	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	transient	transient	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	whereas	whereas	IN	IN	_	11	dep	_	_
14	that	that	DT	DT	_	27	nsubj	_	_
15	mediated	mediate	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	PDTC	pdtc	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	butylated	butylate	VBN	VBN	_	20	amod	_	_
20	hydroxyanisole	hydroxyanisole	NN	NN	_	17	conj	_	_
21	(	(	-LRB-	-LRB-	_	17	punct	_	_
22	but	but	CC	CC	_	23	cc	_	_
23	not	not	RB	RB	_	17	cc	_	_
24	N-acetylcysteine	n-acetylcysteine	NN	NN	_	17	conj	_	_
25	)	)	-RRB-	-RRB-	_	17	punct	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	sustained	sustained	JJ	JJ	_	11	parataxis	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	JNK	jnk	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	correlated	correlate	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-jun	c-jun	NN	NN	_	9	nmod	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	was	be	VBD	VBD	_	14	cop	_	_
14	transient	transient	JJ	JJ	_	9	acl:relcl	_	_
15	after	after	IN	IN	_	16	case	_	_
16	stimulation	stimulation	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	PMA	pma	NN	NN	_	16	nmod	_	_
19	plus	plus	CC	CC	_	18	cc	_	_
20	ionophore	ionophore	NN	NN	_	18	conj	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	prolonged	prolong	VBD	VBD	_	14	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	response	response	NN	NN	_	26	dep	_	_
25	to	to	TO	TO	_	26	case	_	_
26	PDTC	pdtc	NN	NN	_	22	nmod	_	_
27	,	,	,	,	_	9	punct	_	_
28	which	which	WDT	WDT	_	31	nsubj	_	_
29	also	also	RB	RB	_	31	advmod	_	_
30	transiently	transiently	RB	RB	_	31	advmod	_	_
31	induced	induce	VBD	VBD	_	9	acl:relcl	_	_
32	c-fos	c-fos	NN	NN	_	31	dobj	_	_
33	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	JNK	jnk	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	11	nsubj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	PMA	pma	NN	NN	_	5	nmod	_	_
8	plus	plus	CC	CC	_	7	cc	_	_
9	ionophore	ionophore	NN	NN	_	7	conj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	sensitive	sensitive	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	inhibitors	inhibitor	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	13	nmod	_	_
17	involving	involve	VBG	VBG	_	16	acl	_	_
18	Ca2+	ca2+	NN	NN	_	26	compound	_	_
19	,	,	,	,	_	18	punct	_	_
20	protein	protein	NN	NN	_	22	compound	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	C	c	NN	NN	_	18	conj	_	_
23	,	,	,	,	_	18	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	tyrosine	tyrosine	NN	NN	_	18	conj	_	_
26	phosphorylation	phosphorylation	NN	NN	_	17	dobj	_	_
27	,	,	,	,	_	13	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	failed	fail	VBD	VBD	_	13	acl:relcl	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	inhibit	inhibit	VB	VB	_	29	xcomp	_	_
32	the	the	DT	DT	_	33	det	_	_
33	activation	activation	NN	NN	_	31	dobj	_	_
34	mediated	mediate	VBN	VBN	_	33	acl	_	_
35	by	by	IN	IN	_	36	case	_	_
36	PDTC	pdtc	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	Transfection	transfection	NN	NN	_	33	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	trans-dominant	trans-dominant	JJ	JJ	_	6	amod	_	_
4	negative	negative	JJ	JJ	_	6	amod	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	vectors	vector	NNS	NNS	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ras	ras	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	raf	raf	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	together	together	RB	RB	_	6	cc	_	_
13	with	with	IN	IN	_	12	dep	_	_
14	AP-1-dependent	ap-1-dependent	JJ	JJ	_	16	amod	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	constructs	construct	NNS	NNS	_	6	conj	_	_
17	,	,	,	,	_	1	punct	_	_
18	as	as	RB	RB	_	1	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	Western	western	NN	NN	_	23	compound	_	_
22	blot	blot	NN	NN	_	23	compound	_	_
23	analysis	analysis	NN	NN	_	1	conj	_	_
24	using	use	VBG	VBG	_	23	acl	_	_
25	anti-ERK	anti-erk	JJ	JJ	_	31	amod	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	extracellular	extracellular	JJ	JJ	_	29	amod	_	_
28	signal-regulated	signal-regulated	JJ	JJ	_	29	amod	_	_
29	kinase	kinase	NN	NN	_	25	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	antibodies	antibody	NNS	NNS	_	24	dobj	_	_
32	,	,	,	,	_	1	punct	_	_
33	indicated	indicate	VBD	VBD	_	0	root	_	_
34	that	that	IN	IN	_	40	mark	_	_
35	the	the	DT	DT	_	37	det	_	_
36	Ras/Raf/ERK	ras/raf/erk	NN	NN	_	37	compound	_	_
37	pathway	pathway	NN	NN	_	40	nsubj	_	_
38	did	do	VBD	VBD	_	40	aux	_	_
39	not	not	RB	RB	_	40	neg	_	_
40	appear	appear	VB	VB	_	33	ccomp	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	mediate	mediate	VB	VB	_	40	xcomp	_	_
43	the	the	DT	DT	_	44	det	_	_
44	effect	effect	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	antioxidant	antioxidant	NN	NN	_	44	nmod	_	_
48	.	.	.	.	_	33	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	combined	combined	JJ	JJ	_	5	amod	_	_
5	treatment	treatment	NN	NN	_	19	nsubj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	PDTC	pdtc	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	PMA	pma	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	agents	agent	NNS	NNS	_	7	appos	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	synergize	synergize	VBP	VBP	_	12	acl:relcl	_	_
15	on	on	IN	IN	_	17	case	_	_
16	AP-1	ap-1	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	resulted	result	VBD	VBD	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	persistent	persistent	JJ	JJ	_	23	amod	_	_
23	phosphorylation	phosphorylation	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	ERK-2	erk-2	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	identify	identify	VBP	VBP	_	0	root	_	_
7	JNK	jnk	NN	NN	_	6	dobj	_	_
8	as	as	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	target	target	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	antioxidant	antioxidant	JJ	JJ	_	13	amod	_	_
13	agents	agent	NNS	NNS	_	10	nmod	_	_
14	which	which	WDT	WDT	_	17	nsubjpass	_	_
15	can	can	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	regulated	regulate	VBN	VBN	_	10	acl:relcl	_	_
18	differentially	differentially	RB	RB	_	17	advmod	_	_
19	under	under	IN	IN	_	23	case	_	_
20	oxidant	oxidant	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	antioxidant	antioxidant	JJ	JJ	_	20	conj	_	_
23	conditions	condition	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Cytomegalovirus	cytomegalovirus	NN	NN	_	2	nsubj	_	_
2	modulates	modulate	VBZ	VBZ	_	0	root	_	_
3	interleukin-6	interleukin-6	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	.	.	.	.	_	2	punct	_	_

1	Complications	complication	NNS	NNS	_	5	nsubj	_	_
2	after	after	IN	IN	_	4	case	_	_
3	lung	lung	NN	NN	_	4	compound	_	_
4	transplantation	transplantation	NN	NN	_	1	nmod	_	_
5	include	include	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	development	development	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	rejection	rejection	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	an	a	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	incidence	incidence	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	infection	infection	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	particularly	particularly	RB	RB	_	19	advmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	cytomegalovirus	cytomegalovirus	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CMV	cmv	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	5	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	suggested	suggest	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	interleukin	interleukin	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IL	il	NN	NN	_	14	nsubjpass	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	-6	-6	CD	CD	_	9	nummod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	5	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	detect	detect	VB	VB	_	14	xcomp	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	infection	infection	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	rejection	rejection	NN	NN	_	18	conj	_	_
21	after	after	IN	IN	_	23	case	_	_
22	lung	lung	NN	NN	_	23	compound	_	_
23	transplantation	transplantation	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	6	dep	_	_
2	addition	addition	NN	NN	_	6	nsubj	_	_
3	,	,	,	,	_	6	punct	_	_
4	IL-6	il-6	NN	NN	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	play	play	VB	VB	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	development	development	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	bronchiolitis	bronchiolitis	NN	NN	_	14	compound	_	_
14	obliterans	obliteran	NNS	NNS	_	11	nmod	_	_
15	after	after	IN	IN	_	16	case	_	_
16	transplantation	transplantation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	CMV	cmv	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	associated	associate	VBN	VBN	_	16	advcl	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	development	development	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	bronchiolitis	bronchiolitis	NN	NN	_	11	compound	_	_
11	obliterans	obliteran	NNS	NNS	_	8	nmod	_	_
12	after	after	IN	IN	_	13	case	_	_
13	transplantation	transplantation	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	determined	determine	VBD	VBD	_	0	root	_	_
17	whether	whether	IN	IN	_	19	mark	_	_
18	CMV	cmv	NN	NN	_	19	nsubj	_	_
19	induces	induce	VBZ	VBZ	_	16	ccomp	_	_
20	IL-6	il-6	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	CMV	cmv	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	6	nsubj	_	_
6	increased	increase	VBD	VBD	_	2	ccomp	_	_
7	both	both	CC	CC	_	9	cc:preconj	_	_
8	IL-6	il-6	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	mRNA	mrna	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	11	det	_	_
6	CMV	cmv	NN	NN	_	11	compound	_	_
7	immediate	immediate	JJ	JJ	_	11	amod	_	_
8	early	early	JJ	JJ	_	11	amod	_	_
9	1	1	CD	CD	_	11	nummod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	product	product	NN	NN	_	12	nsubj	_	_
12	increased	increase	VBD	VBD	_	3	ccomp	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	IL-6	il-6	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	CMV	cmv	NN	NN	_	10	compound	_	_
6	immediate	immediate	JJ	JJ	_	10	amod	_	_
7	early	early	JJ	JJ	_	10	amod	_	_
8	1	1	CD	CD	_	10	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	product	product	NN	NN	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	upon	upon	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	specific	specific	JJ	JJ	_	21	amod	_	_
18	transcription	transcription	NN	NN	_	21	compound	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	sites	site	NNS	NNS	_	15	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-6	il-6	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	15	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	CMV	cmv	NN	NN	_	10	nsubj	_	_
6	may	may	MD	MD	_	10	aux	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	cofactor	cofactor	NN	NN	_	3	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	development	development	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	rejection	rejection	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	infection	infection	NN	NN	_	15	conj	_	_
18	after	after	IN	IN	_	19	case	_	_
19	transplantation	transplantation	NN	NN	_	13	nmod	_	_
20	through	through	IN	IN	_	22	case	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	effects	effect	NNS	NNS	_	13	nmod	_	_
23	on	on	IN	IN	_	24	case	_	_
24	IL-6	il-6	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	E3	e3	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	5	amod	_	_
5	transcript	transcript	NN	NN	_	1	appos	_	_
6	directly	directly	RB	RB	_	7	advmod	_	_
7	regulated	regulate	VBN	VBN	_	5	acl	_	_
8	by	by	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
11	acid	acid	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	6	amod	_	_
2	acid	acid	NN	NN	_	6	nmod:npmod	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	RA	ra	NN	NN	_	6	nmod:npmod	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	-induced	-induced	JJ	JJ	_	7	amod	_	_
7	maturation	maturation	NN	NN	_	21	nsubjpass	_	_
8	mediated	mediate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	retinoic	retinoic	JJ	JJ	_	14	amod	_	_
12	acid	acid	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	8	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	RAR	rar	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	has	have	VBZ	VBZ	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	implicated	implicate	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	24	case	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	development	development	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	differential	differential	JJ	JJ	_	6	amod	_	_
5	hybridization	hybridization	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cDNA	cdna	NN	NN	_	10	compound	_	_
10	library	library	NN	NN	_	6	nmod	_	_
11	constructed	construct	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	murine	murine	JJ	JJ	_	19	amod	_	_
15	RA-inducible	ra-inducible	JJ	JJ	_	19	amod	_	_
16	MPRO	mpro	NN	NN	_	19	compound	_	_
17	promyelocyte	promyelocyte	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	11	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	identify	identify	VB	VB	_	3	advcl	_	_
22	immediate-early	immediate-early	JJ	JJ	_	23	amod	_	_
23	genes	gene	NNS	NNS	_	21	dobj	_	_
24	induced	induce	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	RA	ra	NN	NN	_	24	nmod	_	_
27	during	during	IN	IN	_	29	case	_	_
28	granulocytic	granulocytic	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	E3	e3	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	one	one	CD	CD	_	1	appos	_	_
4	of	of	IN	IN	_	6	case	_	_
5	nine	nine	CD	CD	_	6	nummod	_	_
6	sequences	sequence	NNS	NNS	_	3	nmod	_	_
7	identified	identify	VBN	VBN	_	6	acl	_	_
8	,	,	,	,	_	1	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	upregulated	upregulate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	immediate-early	immediate-early	JJ	JJ	_	14	amod	_	_
14	manner	manner	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	with	with	IN	IN	_	19	mark	_	_
17	transcript	transcript	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	19	nsubj	_	_
19	peaking	peak	VBG	VBG	_	10	advcl	_	_
20	after	after	IN	IN	_	22	case	_	_
21	60	60	CD	CD	_	22	nummod	_	_
22	minutes	minute	NNS	NNS	_	19	nmod	_	_
23	exposure	exposure	NN	NN	_	22	dep	_	_
24	to	to	TO	TO	_	25	case	_	_
25	RA	ra	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	E3	e3	NN	NN	_	2	compound	_	_
2	transcripts	transcript	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	RA-inducible	ra-inducible	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	HL60	hl60	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	but	but	CC	CC	_	4	cc	_	_
10	not	not	RB	RB	_	14	neg	_	_
11	in	in	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	RA-resistant	ra-resistant	JJ	JJ	_	14	amod	_	_
14	subclone	subclone	NN	NN	_	4	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	HL60R	hl60r	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	harbors	harbor	VBZ	VBZ	_	14	acl:relcl	_	_
20	a	a	DT	DT	_	24	det	_	_
21	mutated	mutate	VBN	VBN	_	24	amod	_	_
22	RAR	rar	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	19	dobj	_	_
25	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	when	when	WRB	WRB	_	7	advmod	_	_
4	HL60R	hl60r	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	transduced	transduce	VBN	VBN	_	19	advcl	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	copy	copy	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	RAR	rar	NN	NN	_	16	compound	_	_
15	alpha	alpha	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	RA	ra	NN	NN	_	19	nsubj	_	_
19	induced	induce	VBD	VBD	_	0	root	_	_
20	a	a	DT	DT	_	22	det	_	_
21	10-fold	10-fold	JJ	JJ	_	22	amod	_	_
22	increase	increase	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	E3	e3	NN	NN	_	26	compound	_	_
25	mRNA	mrna	NN	NN	_	26	compound	_	_
26	levels	level	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	E3	e3	NN	NN	_	2	compound	_	_
2	transcripts	transcript	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	13	case	_	_
6	the	the	DT	DT	_	13	det	_	_
7	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	B-lymphoid	b-lymphoid	JJ	JJ	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	erythroid	erythroid	JJ	JJ	_	7	conj	_	_
13	lineages	lineage	NNS	NNS	_	4	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	absent	absent	JJ	JJ	_	4	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	nonhematopoietic	nonhematopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	encode	encode	VBP	VBP	_	4	conj	_	_
22	a	a	DT	DT	_	28	det	_	_
23	highly	highly	RB	RB	_	24	advmod	_	_
24	hydrophobic	hydrophobic	JJ	JJ	_	28	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	potentially	potentially	RB	RB	_	27	advmod	_	_
27	phosphorylated	phosphorylate	VBN	VBN	_	24	dep	_	_
28	polypeptide	polypeptide	NN	NN	_	21	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	unknown	unknown	JJ	JJ	_	31	amod	_	_
31	function	function	NN	NN	_	28	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	significant	significant	JJ	JJ	_	34	amod	_	_
34	homology	homology	NN	NN	_	28	nmod	_	_
35	to	to	TO	TO	_	38	case	_	_
36	a	a	DT	DT	_	38	det	_	_
37	putative	putative	JJ	JJ	_	38	amod	_	_
38	protein	protein	NN	NN	_	34	nmod	_	_
39	expressed	express	VBN	VBN	_	38	acl	_	_
40	in	in	IN	IN	_	42	case	_	_
41	myeloid	myeloid	JJ	JJ	_	42	amod	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	murine	murine	JJ	JJ	_	4	amod	_	_
3	E3	e3	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	nsubj	_	_
5	harbors	harbor	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	12	det	_	_
7	single	single	JJ	JJ	_	12	amod	_	_
8	bipartite	bipartite	JJ	JJ	_	12	amod	_	_
9	retinoic	retinoic	JJ	JJ	_	12	amod	_	_
10	acid	acid	NN	NN	_	12	compound	_	_
11	response	response	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	5	dobj	_	_
13	which	which	WDT	WDT	_	18	nsubj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	transient	transient	NN	NN	_	17	compound	_	_
16	transfection	transfection	NN	NN	_	17	compound	_	_
17	assays	assay	NNS	NNS	_	18	nmod	_	_
18	conferred	confer	VBD	VBD	_	12	acl:relcl	_	_
19	RA	ra	NN	NN	_	20	compound	_	_
20	sensitivity	sensitivity	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	E3	e3	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	3	ccomp	_	_
10	that	that	WDT	WDT	_	14	nsubj	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	an	a	DT	DT	_	14	det	_	_
13	immediate	immediate	JJ	JJ	_	14	amod	_	_
14	target	target	NN	NN	_	9	acl:relcl	_	_
15	for	for	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	activated	activate	VBN	VBN	_	19	amod	_	_
18	RAR	rar	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	14	nmod	_	_
20	during	during	IN	IN	_	21	case	_	_
21	myelopoiesis	myelopoiesis	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Interstitial	interstitial	JJ	JJ	_	2	amod	_	_
2	deletion	deletion	NN	NN	_	3	nsubj	_	_
3	constitutes	constitute	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	major	major	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	loss	loss	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	heterozygosity	heterozygosity	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	chromosome	chromosome	NN	NN	_	13	compound	_	_
13	20q	20q	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	polycythemia	polycythemia	NN	NN	_	16	compound	_	_
16	vera	vera	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	acquired	acquire	VBN	VBN	_	3	amod	_	_
3	deletion	deletion	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	long	long	JJ	JJ	_	7	amod	_	_
7	arm	arm	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	chromosome	chromosome	NN	NN	_	7	nmod	_	_
10	20	20	CD	CD	_	9	nummod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	recurrent	recurrent	JJ	JJ	_	14	amod	_	_
14	abnormality	abnormality	NN	NN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	myeloproliferative	myeloproliferative	JJ	JJ	_	17	amod	_	_
17	disorders	disorder	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	particularly	particularly	RB	RB	_	24	advmod	_	_
20	polycythemia	polycythemia	NN	NN	_	21	compound	_	_
21	vera	vera	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	myelodysplastic	myelodysplastic	JJ	JJ	_	21	conj	_	_
24	syndromes	syndrome	NNS	NNS	_	17	appos	_	_
25	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	association	association	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	20q	20q	NN	NN	_	5	compound	_	_
5	deletions	deletion	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	11	case	_	_
7	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
8	``	``	``	``	_	11	punct	_	_
9	stem	stem	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	disorders	disorder	NNS	NNS	_	2	nmod	_	_
12	suggests	suggest	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	16	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	deletions	deletion	NNS	NNS	_	16	nsubj	_	_
16	mark	mark	VBP	VBP	_	12	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	site	site	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	one	one	CD	CD	_	23	nummod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	more	more	JJR	JJR	_	20	conj	_	_
23	genes	gene	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	loss	loss	NN	NN	_	30	nsubj	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	inactivation	inactivation	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	which	which	WDT	WDT	_	25	nmod	_	_
30	plays	play	VBZ	VBZ	_	18	acl:relcl	_	_
31	a	a	DT	DT	_	32	det	_	_
32	role	role	NN	NN	_	30	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	regulation	regulation	NN	NN	_	30	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	normal	normal	JJ	JJ	_	39	amod	_	_
38	hematopoietic	hematopoietic	JJ	JJ	_	39	amod	_	_
39	progenitors	progenitor	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	performed	perform	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	detailed	detailed	JJ	JJ	_	8	amod	_	_
7	molecular	molecular	JJ	JJ	_	8	amod	_	_
8	analysis	analysis	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	20q	20q	JJ	JJ	_	11	amod	_	_
11	deletions	deletion	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	18	case	_	_
13	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
14	blood	blood	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PB	pb	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	granulocytes	granulocyte	NNS	NNS	_	11	nmod	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	defined	define	VBN	VBN	_	4	conj	_	_
21	a	a	DT	DT	_	24	det	_	_
22	commonly	commonly	RB	RB	_	23	advmod	_	_
23	deleted	delete	VBN	VBN	_	24	amod	_	_
24	region	region	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	16	16	CD	CD	_	28	compound	_	_
27	to	to	TO	TO	_	28	dep	_	_
28	21	21	CD	CD	_	29	nummod	_	_
29	centimorgan	centimorgan	NN	NN	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	cM	cm	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RBR	RBR	_	3	advmod	_	_
3	reduce	reduce	VB	VB	_	13	dep	_	_
4	the	the	DT	DT	_	5	det	_	_
5	size	size	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	common	common	JJ	JJ	_	10	amod	_	_
9	deleted	delete	VBN	VBN	_	10	amod	_	_
10	region	region	NN	NN	_	5	nmod	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	searched	search	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	16	case	_	_
15	small	small	JJ	JJ	_	16	amod	_	_
16	deletions	deletion	NNS	NNS	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	mitotic	mitotic	JJ	JJ	_	20	amod	_	_
19	recombination	recombination	NN	NN	_	20	compound	_	_
20	events	event	NNS	NNS	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	neither	neither	DT	DT	_	27	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	22	nmod	_	_
25	would	would	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	detected	detect	VBN	VBN	_	16	acl:relcl	_	_
28	by	by	IN	IN	_	30	case	_	_
29	conventional	conventional	JJ	JJ	_	30	amod	_	_
30	cytogenetics	cytogenetic	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	48	48	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	3	dobj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	polycythemia	polycythemia	NN	NN	_	8	compound	_	_
8	vera	vera	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	four	four	CD	CD	_	11	nummod	_	_
11	patients	patient	NNS	NNS	_	5	conj	_	_
12	with	with	IN	IN	_	14	case	_	_
13	idiopathic	idiopathic	JJ	JJ	_	14	amod	_	_
14	myelofibrosis	myelofibrosis	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	each	each	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	cytogenetic	cytogenetic	JJ	JJ	_	6	amod	_	_
6	analysis	analysis	NN	NN	_	9	nsubj	_	_
7	had	have	VBD	VBD	_	9	aux	_	_
8	either	either	RB	RB	_	9	advmod	_	_
9	failed	fail	VBN	VBN	_	0	root	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	had	have	VBD	VBD	_	12	aux	_	_
12	shown	show	VBN	VBN	_	9	conj	_	_
13	no	no	DT	DT	_	14	neg	_	_
14	abnormalities	abnormality	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	chromosome	chromosome	NN	NN	_	14	nmod	_	_
17	20	20	CD	CD	_	16	nummod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Seventeen	seventeen	CD	CD	_	3	nummod	_	_
2	microsatellite	microsatellite	NN	NN	_	3	compound	_	_
3	markers	marker	NNS	NNS	_	11	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	span	span	VBP	VBP	_	3	acl:relcl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	common	common	JJ	JJ	_	9	amod	_	_
8	deleted	delete	VBN	VBN	_	9	amod	_	_
9	region	region	NN	NN	_	5	dobj	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	used	use	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	search	search	VB	VB	_	11	xcomp	_	_
14	for	for	IN	IN	_	15	case	_	_
15	loss	loss	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	heterozygosity	heterozygosity	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	granulocyte	granulocyte	NN	NN	_	20	compound	_	_
20	DNA	dna	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	instance	instance	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	microsatellite	microsatellite	NN	NN	_	5	compound	_	_
5	instability	instability	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	total	total	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	880	880	CD	CD	_	13	nummod	_	_
13	comparisons	comparison	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	granulocyte	granulocyte	NN	NN	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	T-cell	t-cell	NN	NN	_	15	conj	_	_
18	DNA	dna	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Granulocyte	granulocyte	NN	NN	_	2	compound	_	_
2	DNA	dna	NN	NN	_	6	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	four	four	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	allele	allele	NN	NN	_	8	compound	_	_
8	loss	loss	NN	NN	_	6	dobj	_	_
9	on	on	IN	IN	_	10	case	_	_
10	20q	20q	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	each	each	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	8	nmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	allele	allele	NN	NN	_	6	compound	_	_
6	loss	loss	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	caused	cause	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	interstitial	interstitial	JJ	JJ	_	12	amod	_	_
12	deletion	deletion	NN	NN	_	8	nmod	_	_
13	because	because	IN	IN	_	19	mark	_	_
14	heterozygosity	heterozygosity	NN	NN	_	19	nsubjpass	_	_
15	at	at	IN	IN	_	17	case	_	_
16	distal	distal	JJ	JJ	_	17	amod	_	_
17	markers	marker	NNS	NNS	_	14	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	retained	retain	VBN	VBN	_	8	advcl	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	because	because	IN	IN	_	25	mark	_	_
22	quantitative	quantitative	JJ	JJ	_	24	amod	_	_
23	Southern	southern	NN	NN	_	24	compound	_	_
24	blotting	blotting	NN	NN	_	25	nsubj	_	_
25	demonstrated	demonstrate	VBD	VBD	_	19	conj	_	_
26	hemizygosity	hemizygosity	NN	NN	_	25	dobj	_	_
27	.	.	.	.	_	8	punct	_	_

1	Loss	loss	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	heterozygosity	heterozygosity	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	PB	pb	NN	NN	_	6	compound	_	_
6	granulocytes	granulocyte	NNS	NNS	_	1	nmod	_	_
7	would	would	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	masked	mask	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	numbers	number	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	granulocytes	granulocyte	NNS	NNS	_	15	nmod	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	derived	derive	VBN	VBN	_	18	acl	_	_
21	from	from	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	malignant	malignant	JJ	JJ	_	24	amod	_	_
24	clone	clone	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Therefore	therefore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	androgen	androgen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	12	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HUMARA	humara	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	determine	determine	VB	VB	_	12	xcomp	_	_
15	granulocyte	granulocyte	NN	NN	_	16	compound	_	_
16	clonality	clonality	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	21	21	CD	CD	_	4	compound	_	_
3	of	of	IN	IN	_	4	advmod	_	_
4	27	27	CD	CD	_	7	nummod	_	_
5	informative	informative	JJ	JJ	_	7	amod	_	_
6	female	female	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	15	nmod	_	_
8	the	the	DT	DT	_	9	det	_	_
9	majority	majority	NN	NN	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	granulocytes	granulocyte	NNS	NNS	_	9	nmod	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	clonally	clonally	RB	RB	_	15	advmod	_	_
15	derived	derive	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	5	5	CD	CD	_	3	nummod	_	_
3	patients	patient	NNS	NNS	_	6	nmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	granulocytes	granulocyte	NNS	NNS	_	6	nsubj	_	_
6	appeared	appear	VBD	VBD	_	0	root	_	_
7	polyclonal	polyclonal	JJ	JJ	_	6	xcomp	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	in	in	IN	IN	_	11	case	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	patient	patient	NN	NN	_	16	nmod	_	_
12	unilateral	unilateral	JJ	JJ	_	14	amod	_	_
13	X	x	NN	NN	_	14	compound	_	_
14	inactivation	inactivation	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	6	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	granulocytes	granulocyte	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	T	t	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	,	,	,	,	_	25	punct	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	vast	vast	JJ	JJ	_	9	amod	_	_
9	majority	majority	NN	NN	_	25	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	9	nmod	_	_
12	presented	present	VBN	VBN	_	11	acl	_	_
13	here	here	RB	RB	_	12	advmod	_	_
14	,	,	,	,	_	25	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	failure	failure	NN	NN	_	25	nsubjpass	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	detect	detect	VB	VB	_	16	acl	_	_
19	loss	loss	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	heterozygosity	heterozygosity	NN	NN	_	19	nmod	_	_
22	can	can	MD	MD	_	25	aux	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	attributed	attribute	VBN	VBN	_	3	ccomp	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	presence	presence	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	normal	normal	JJ	JJ	_	32	amod	_	_
31	polyclonal	polyclonal	JJ	JJ	_	32	amod	_	_
32	granulocytes	granulocyte	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	allele	allele	NN	NN	_	7	compound	_	_
7	loss	loss	NN	NN	_	17	nsubj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	chromosome	chromosome	NN	NN	_	10	compound	_	_
10	20q	20q	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	polycythemia	polycythemia	NN	NN	_	13	compound	_	_
13	vera	vera	NN	NN	_	7	nmod	_	_
14	does	do	VBZ	VBZ	_	17	aux	_	_
15	not	not	RB	RB	_	17	neg	_	_
16	commonly	commonly	RB	RB	_	17	advmod	_	_
17	involve	involve	VB	VB	_	4	ccomp	_	_
18	mitotic	mitotic	JJ	JJ	_	19	amod	_	_
19	recombination	recombination	NN	NN	_	17	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	chromosome	chromosome	NN	NN	_	22	compound	_	_
22	loss	loss	NN	NN	_	19	conj	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	that	that	IN	IN	_	30	mark	_	_
25	microsatellite	microsatellite	NN	NN	_	26	compound	_	_
26	instability	instability	NN	NN	_	30	nsubj	_	_
27	is	be	VBZ	VBZ	_	30	cop	_	_
28	a	a	DT	DT	_	30	det	_	_
29	rare	rare	JJ	JJ	_	30	amod	_	_
30	event	event	NN	NN	_	17	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	disorder	disorder	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	DNA-binding	dna-binding	JJ	JJ	_	2	amod	_	_
2	phosphoproteins	phosphoprotein	NNS	NNS	_	0	root	_	_
3	induced	induce	VBN	VBN	_	2	acl	_	_
4	after	after	IN	IN	_	7	case	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	nmod	_	_
8	:	:	:	:	_	2	punct	_	_
9	effects	effect	NNS	NNS	_	2	dep	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	0	root	_	_
3	novel	novel	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	2	dobj	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	early	early	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	5	nmod	_	_
11	during	during	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	used	use	VBD	VBD	_	2	parataxis	_	_
21	a	a	DT	DT	_	27	det	_	_
22	high-resolution	high-resolution	JJ	JJ	_	27	amod	_	_
23	,	,	,	,	_	27	punct	_	_
24	two-dimensional	two-dimensional	JJ	JJ	_	27	amod	_	_
25	gel	gel	NN	NN	_	27	compound	_	_
26	electrophoresis	electrophoresis	NN	NN	_	27	compound	_	_
27	system	system	NN	NN	_	20	dobj	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	identify	identify	VB	VB	_	27	acl	_	_
30	nuclear	nuclear	JJ	JJ	_	38	amod	_	_
31	,	,	,	,	_	38	punct	_	_
32	deoxyribonucleic	deoxyribonucleic	JJ	JJ	_	38	amod	_	_
33	acid	acid	NN	NN	_	38	compound	_	_
34	(	(	-LRB-	-LRB-	_	38	punct	_	_
35	DNA	dna	NN	NN	_	38	compound	_	_
36	)	)	-RRB-	-RRB-	_	38	punct	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	proteins	protein	NNS	NNS	_	29	dobj	_	_
39	exhibiting	exhibit	VBG	VBG	_	38	acl	_	_
40	rapid	rapid	JJ	JJ	_	41	amod	_	_
41	changes	change	NNS	NNS	_	39	dobj	_	_
42	in	in	IN	IN	_	43	case	_	_
43	phosphorylation	phosphorylation	NN	NN	_	41	nmod	_	_
44	following	follow	VBG	VBG	_	46	case	_	_
45	cell	cell	NN	NN	_	46	compound	_	_
46	stimulation	stimulation	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	18	18	CD	CD	_	5	nummod	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	2	dobj	_	_
6	whose	whose	WP$	WP$	_	8	nmod:poss	_	_
7	phosphorylation	phosphorylation	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	9	nsubj	_	_
9	changed	change	VBD	VBD	_	5	acl:relcl	_	_
10	more	more	JJR	JJR	_	9	dobj	_	_
11	than	than	IN	IN	_	10	amod	_	_
12	5-fold	5-fold	RB	RB	_	10	advmod	_	_
13	upon	upon	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	these	these	DT	DT	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	11	11	CD	CD	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	possess	possess	VB	VB	_	6	xcomp	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	properties	property	NNS	NNS	_	8	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	11	11	CD	CD	_	3	nummod	_	_
3	phosphoproteins	phosphoprotein	NNS	NNS	_	14	nsubjpass	_	_
4	with	with	IN	IN	_	6	case	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	along	along	IN	IN	_	11	case	_	_
9	with	with	IN	IN	_	11	case	_	_
10	4	4	CD	CD	_	11	nummod	_	_
11	others	other	NNS	NNS	_	14	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	analyzed	analyze	VBN	VBN	_	0	root	_	_
15	further	further	RB	RB	_	14	advmod	_	_
16	.	.	.	.	_	14	punct	_	_

1	Phosphoamino	phosphoamino	NN	NN	_	3	compound	_	_
2	acid	acid	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	sets	set	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	proteins	protein	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	phosphorylated	phosphorylate	VBN	VBN	_	12	amod	_	_
12	residues	residue	NNS	NNS	_	8	nmod	_	_
13	Kinetic	kinetic	JJ	JJ	_	14	amod	_	_
14	analysis	analysis	NN	NN	_	23	nsubjpass	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	selected	select	VBN	VBN	_	21	amod	_	_
21	proteins	protein	NNS	NNS	_	17	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	performed	perform	VBN	VBN	_	6	acl:relcl	_	_
24	and	and	CC	CC	_	4	cc	_	_
25	revealed	reveal	VBD	VBD	_	4	conj	_	_
26	a	a	DT	DT	_	28	det	_	_
27	complex	complex	JJ	JJ	_	28	amod	_	_
28	group	group	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	transient	transient	JJ	JJ	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	sustained	sustained	JJ	JJ	_	30	conj	_	_
33	responses	response	NNS	NNS	_	30	dep	_	_
34	to	to	TO	TO	_	36	case	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	activation-induced	activation-induced	JJ	JJ	_	5	amod	_	_
5	changes	change	NNS	NNS	_	13	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	one	one	CD	CD	_	8	nummod	_	_
8	set	set	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	phosphoproteins	phosphoprotein	NNS	NNS	_	8	nmod	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	dramatically	dramatically	RB	RB	_	13	advmod	_	_
13	inhibited	inhibit	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	cyclosporin	cyclosporin	NN	NN	_	16	compound	_	_
16	A	a	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	these	these	DT	DT	_	5	det	_	_
5	phosphoproteins	phosphoprotein	NNS	NNS	_	9	nsubjpass	_	_
6	may	may	MD	MD	_	9	aux	_	_
7	be	be	VB	VB	_	9	auxpass	_	_
8	directly	directly	RB	RB	_	9	advmod	_	_
9	involved	involve	VBN	VBN	_	2	ccomp	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	regulating	regulate	VBG	VBG	_	9	advcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	response	response	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	by	by	IN	IN	_	20	case	_	_
19	external	external	JJ	JJ	_	20	amod	_	_
20	stimuli	stimulus	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	steroid-regulated	steroid-regulated	JJ	JJ	_	5	amod	_	_
5	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	murine	murine	JJ	JJ	_	9	amod	_	_
8	thymoma	thymoma	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Early	early	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	8	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	murine	murine	JJ	JJ	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	2	nmod	_	_
8	indicated	indicate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	24	mark	_	_
10	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
11	transactivation	transactivation	NN	NN	_	12	compound	_	_
12	functions	function	NNS	NNS	_	24	nsubjpass	_	_
13	encoded	encode	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	GR	gr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	N-terminal	n-terminal	JJ	JJ	_	22	amod	_	_
22	domain	domain	NN	NN	_	13	nmod	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	8	ccomp	_	_
25	for	for	IN	IN	_	27	case	_	_
26	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	27	amod	_	_
27	apoptosis	apoptosis	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	more	more	RBR	RBR	_	4	advmod	_	_
4	recent	recent	JJ	JJ	_	5	amod	_	_
5	studies	study	NNS	NNS	_	12	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	5	nmod	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	suggested	suggest	VBN	VBN	_	0	root	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	N-terminal	n-terminal	JJ	JJ	_	16	amod	_	_
16	domain	domain	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	necessary	necessary	JJ	JJ	_	12	ccomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	steroid-regulated	steroid-regulated	JJ	JJ	_	22	amod	_	_
22	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	that	that	IN	IN	_	32	mark	_	_
25	GR-mediated	gr-mediated	JJ	JJ	_	26	amod	_	_
26	transrepression	transrepression	NN	NN	_	32	nsubj	_	_
27	may	may	MD	MD	_	32	aux	_	_
28	be	be	VB	VB	_	32	cop	_	_
29	the	the	DT	DT	_	32	det	_	_
30	more	more	RBR	RBR	_	31	advmod	_	_
31	critical	critical	JJ	JJ	_	32	amod	_	_
32	mechanism	mechanism	NN	NN	_	19	conj	_	_
33	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	20	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	contribution	contribution	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	GR	gr	NN	NN	_	11	compound	_	_
9	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
10	transactivation	transactivation	NN	NN	_	11	compound	_	_
11	domain	domain	NN	NN	_	5	nmod	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	mediating	mediate	VBG	VBG	_	5	acl	_	_
14	murine	murine	JJ	JJ	_	16	amod	_	_
15	thymocyte	thymocyte	NN	NN	_	16	compound	_	_
16	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	20	punct	_	_
18	we	we	PRP	PRP	_	20	nsubj	_	_
19	stably	stably	RB	RB	_	20	advmod	_	_
20	transfected	transfect	VBD	VBD	_	0	root	_	_
21	GR	gr	NN	NN	_	20	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	GR	gr	NN	NN	_	24	compound	_	_
24	variants	variant	NNS	NNS	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	androgen	androgen	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	21	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	AR	ar	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	into	into	IN	IN	_	38	case	_	_
34	receptor-negative	receptor-negative	JJ	JJ	_	38	amod	_	_
35	S49	s49	NN	NN	_	38	compound	_	_
36	murine	murine	JJ	JJ	_	38	amod	_	_
37	thymoma	thymoma	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	20	nmod	_	_
39	.	.	.	.	_	20	punct	_	_

1	GR	gr	NN	NN	_	3	compound	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	rate-limiting	rate-limiting	JJ	JJ	_	5	xcomp	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	initiating	initiate	VBG	VBG	_	8	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	apoptotic	apoptotic	JJ	JJ	_	13	amod	_	_
13	pathway	pathway	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	a	a	DT	DT	_	18	det	_	_
17	positive	positive	JJ	JJ	_	18	amod	_	_
18	correlation	correlation	NN	NN	_	39	nsubjpass	_	_
19	between	between	IN	IN	_	21	case	_	_
20	steroid	steroid	NN	NN	_	21	compound	_	_
21	sensitivity	sensitivity	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	GR-mediated	gr-mediated	JJ	JJ	_	24	amod	_	_
24	induction	induction	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	37	case	_	_
26	an	a	DT	DT	_	37	det	_	_
27	integrated	integrate	VBN	VBN	_	37	amod	_	_
28	mouse	mouse	NN	NN	_	31	compound	_	_
29	mammary	mammary	JJ	JJ	_	31	amod	_	_
30	tumor	tumor	NN	NN	_	31	compound	_	_
31	virus	virus	NN	NN	_	37	compound	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	MMTV	mmtv	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	LTR	ltr	NN	NN	_	37	compound	_	_
36	reporter	reporter	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	21	nmod	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	observed	observe	VBN	VBN	_	5	conj	_	_
40	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	GR	gr	NN	NN	_	5	compound	_	_
4	chimeric	chimeric	JJ	JJ	_	5	amod	_	_
5	receptors	receptor	NNS	NNS	_	1	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	14	det	_	_
8	potent	potent	JJ	JJ	_	14	amod	_	_
9	VP16	vp16	NN	NN	_	14	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	E1A	e1a	NN	NN	_	9	conj	_	_
12	viral	viral	JJ	JJ	_	14	amod	_	_
13	transactivation	transactivation	NN	NN	_	14	compound	_	_
14	domains	domain	NNS	NNS	_	6	dobj	_	_
15	in	in	IN	IN	_	21	case	_	_
16	place	place	NN	NN	_	21	dep	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	GR	gr	NN	NN	_	21	compound	_	_
20	N	n	NN	NN	_	21	compound	_	_
21	terminus	terminus	NN	NN	_	6	nmod	_	_
22	revealed	reveal	VBD	VBD	_	0	root	_	_
23	that	that	IN	IN	_	31	mark	_	_
24	even	even	RB	RB	_	27	advmod	_	_
25	low	low	JJ	JJ	_	27	amod	_	_
26	level	level	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	31	nsubj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	receptors	receptor	NNS	NNS	_	27	nmod	_	_
31	resulted	result	VBD	VBD	_	22	ccomp	_	_
32	in	in	IN	IN	_	36	case	_	_
33	both	both	CC	CC	_	36	cc:preconj	_	_
34	enhanced	enhance	VBN	VBN	_	36	amod	_	_
35	steroid	steroid	NN	NN	_	36	compound	_	_
36	sensitivity	sensitivity	NN	NN	_	31	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	MMTV	mmtv	NN	NN	_	39	compound	_	_
39	induction	induction	NN	NN	_	36	conj	_	_
40	,	,	,	,	_	31	punct	_	_
41	thus	thus	RB	RB	_	42	advmod	_	_
42	supporting	support	VBG	VBG	_	31	ccomp	_	_
43	a	a	DT	DT	_	44	det	_	_
44	role	role	NN	NN	_	42	dobj	_	_
45	for	for	IN	IN	_	46	case	_	_
46	transactivation	transactivation	NN	NN	_	44	nmod	_	_
47	in	in	IN	IN	_	48	case	_	_
48	apoptosis	apoptosis	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	found	find	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	AR	ar	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	initiate	initiate	VB	VB	_	5	ccomp	_	_
10	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	S49	s49	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	after	after	IN	IN	_	15	case	_	_
15	treatment	treatment	NN	NN	_	9	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	5	5	CD	CD	_	18	nummod	_	_
18	alpha-dihydrotestosterone	alpha-dihydrotestosterone	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	despite	despite	IN	IN	_	23	case	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	relative	relative	JJ	JJ	_	23	amod	_	_
23	inability	inability	NN	NN	_	9	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	induce	induce	VB	VB	_	23	acl	_	_
26	high	high	JJ	JJ	_	28	amod	_	_
27	level	level	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	MMTV	mmtv	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	7	advcl	_	_
3	this	this	DT	DT	_	2	dobj	_	_
4	further	further	RBR	RBR	_	2	advmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	steroid-regulated	steroid-regulated	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	an	a	DT	DT	_	15	det	_	_
13	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
14	thymocyte-specific	thymocyte-specific	JJ	JJ	_	15	amod	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	called	call	VBN	VBN	_	15	acl	_	_
17	GIG18	gig18	NN	NN	_	16	xcomp	_	_
18	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	GIG18	gig18	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	rapidly	rapidly	RB	RB	_	7	advmod	_	_
7	induced	induce	VBN	VBN	_	2	ccomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	comparable	comparable	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	AR	ar	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	GR	gr	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	demonstrating	demonstrate	VBG	VBG	_	7	xcomp	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	AR	ar	NN	NN	_	22	nsubj	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	indeed	indeed	RB	RB	_	22	advmod	_	_
22	function	function	VB	VB	_	17	ccomp	_	_
23	as	as	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activator	activator	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	S49	s49	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	and	and	CC	CC	_	22	cc	_	_
31	,	,	,	,	_	22	punct	_	_
32	moreover	moreover	RB	RB	_	22	advmod	_	_
33	,	,	,	,	_	22	punct	_	_
34	that	that	IN	IN	_	40	mark	_	_
35	GIG18	gig18	NN	NN	_	36	compound	_	_
36	induction	induction	NN	NN	_	40	nsubj	_	_
37	may	may	MD	MD	_	40	aux	_	_
38	be	be	VB	VB	_	40	cop	_	_
39	a	a	DT	DT	_	40	det	_	_
40	marker	marker	NN	NN	_	22	dep	_	_
41	of	of	IN	IN	_	44	case	_	_
42	early	early	JJ	JJ	_	44	amod	_	_
43	apoptotic	apoptotic	JJ	JJ	_	44	amod	_	_
44	events	event	NNS	NNS	_	40	nmod	_	_
45	in	in	IN	IN	_	47	case	_	_
46	steroid-treated	steroid-treated	JJ	JJ	_	47	amod	_	_
47	cells	cell	NNS	NNS	_	40	nmod	_	_
48	.	.	.	.	_	2	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	support	support	VBP	VBP	_	0	root	_	_
7	our	we	PRP$	PRP$	_	8	nmod:poss	_	_
8	conclusion	conclusion	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	transactivation	transactivation	NN	NN	_	16	nsubj	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	necessary	necessary	JJ	JJ	_	16	amod	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	component	component	NN	NN	_	8	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	S49	s49	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	6	punct	_	_
22	although	although	IN	IN	_	32	mark	_	_
23	an	a	DT	DT	_	25	det	_	_
24	additional	additional	JJ	JJ	_	25	amod	_	_
25	role	role	NN	NN	_	32	nsubjpass	_	_
26	for	for	IN	IN	_	28	case	_	_
27	GR-mediated	gr-mediated	JJ	JJ	_	28	amod	_	_
28	transrepression	transrepression	NN	NN	_	25	nmod	_	_
29	can	can	MD	MD	_	32	aux	_	_
30	not	not	RB	RB	_	32	neg	_	_
31	be	be	VB	VB	_	32	auxpass	_	_
32	excluded	exclude	VBN	VBN	_	6	advcl	_	_
33	.	.	.	.	_	6	punct	_	_

1	Selenium-mediated	selenium-mediated	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	transcription	transcription	NN	NN	_	7	compound	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
10	LTR	ltr	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	7	conj	_	_
12	activity	activity	NN	NN	_	7	dep	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	eukaryotic	eukaryotic	JJ	JJ	_	6	amod	_	_
3	transcription	transcription	NN	NN	_	6	compound	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	inducible	inducible	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	various	various	JJ	JJ	_	16	amod	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	as	as	RB	RB	_	12	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	in	in	IN	IN	_	22	case	_	_
21	HIV-1	hiv-1	NN	NN	_	22	compound	_	_
22	replication	replication	NN	NN	_	12	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	prooxidants	prooxidant	NNS	NNS	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	stimuli	stimulus	NNS	NNS	_	8	conj	_	_
12	eliciting	elicit	VBG	VBG	_	8	acl	_	_
13	oxidative	oxidative	JJ	JJ	_	14	amod	_	_
14	stress	stress	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	8	punct	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	lipopolysaccharide	lipopolysaccharide	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	UV	uv	NN	NN	_	23	compound	_	_
23	irradiation	irradiation	NN	NN	_	18	conj	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	other	other	JJ	JJ	_	26	amod	_	_
26	mediators	mediator	NNS	NNS	_	18	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	antioxidants	antioxidant	NNS	NNS	_	3	nsubj	_	_
3	inhibit	inhibit	VBP	VBP	_	0	root	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	response	response	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	stimuli	stimulus	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	investigated	investigate	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	effects	effect	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	selenium	selenium	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	an	a	DT	DT	_	15	det	_	_
14	integral	integral	JJ	JJ	_	15	amod	_	_
15	component	component	NN	NN	_	11	appos	_	_
16	of	of	IN	IN	_	18	case	_	_
17	glutathione	glutathione	NN	NN	_	18	compound	_	_
18	peroxidase	peroxidase	NN	NN	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GPX	gpx	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	9	punct	_	_
23	on	on	IN	IN	_	26	case	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	9	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	selenium-deprived	selenium-deprived	JJ	JJ	_	3	amod	_	_
3	Jurkat	jurkat	NN	NN	_	12	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	ESb-L	esb-l	NN	NN	_	7	compound	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	3	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	supplementation	supplementation	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	selenium	selenium	NN	NN	_	9	nmod	_	_
12	led	lead	VBD	VBD	_	0	root	_	_
13	to	to	TO	TO	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	substantial	substantial	JJ	JJ	_	16	amod	_	_
16	increase	increase	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	GPX	gpx	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	1	nmod	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	16	nsubjpass	_	_
10	in	in	IN	IN	_	11	case	_	_
11	response	response	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	TNF	tnf	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	inhibited	inhibit	VBN	VBN	_	5	ccomp	_	_
17	under	under	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	conditions	condition	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Likewise	likewise	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	reporter	reporter	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	16	nsubj	_	_
6	using	use	VBG	VBG	_	5	acl	_	_
7	luciferase	luciferase	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	6	dobj	_	_
9	driven	drive	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	repeat	repeat	NN	NN	_	9	nmod	_	_
16	showed	show	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	inhibition	inhibition	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	25	compound	_	_
23	controlled	controlled	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	19	nmod	_	_
26	by	by	IN	IN	_	27	case	_	_
27	selenium	selenium	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	selenium	selenium	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	specific	specific	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	since	since	IN	IN	_	21	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	21	nsubjpass	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	AP-1	ap-1	NN	NN	_	17	dep	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	suppressed	suppress	VBN	VBN	_	6	advcl	_	_
22	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	selenium	selenium	NN	NN	_	6	compound	_	_
6	supplementation	supplementation	NN	NN	_	9	nsubjpass	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	3	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	modulate	modulate	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	target	target	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	HIV-1	hiv-1	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Suppression	suppression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-jun	c-jun	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	antisense	antisense	JJ	JJ	_	6	amod	_	_
6	oligonucleotides	oligonucleotide	NNS	NNS	_	1	nmod	_	_
7	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	adhesion	adhesion	NN	NN	_	7	dobj	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	respiratory	respiratory	JJ	JJ	_	13	amod	_	_
13	burst	burst	NN	NN	_	9	conj	_	_
14	during	during	IN	IN	_	17	case	_	_
15	phorbol	phorbol	NN	NN	_	16	nmod:npmod	_	_
16	ester-induced	ester-induced	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	7	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	U937	u937	NN	NN	_	22	compound	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	monoblastic	monoblastic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	immediate	immediate	JJ	JJ	_	10	amod	_	_
8	early	early	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	c-jun	c-jun	NN	NN	_	4	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	4	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	phorbol	phorbol	NN	NN	_	21	nmod:npmod	_	_
16	12-myristate	12-myristate	NN	NN	_	21	nmod:npmod	_	_
17	13-acetate	13-acetate	NN	NN	_	21	nmod:npmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	PMA	pma	NN	NN	_	21	nmod:npmod	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	-induced	-induced	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	13	conj	_	_
23	in	in	IN	IN	_	27	case	_	_
24	U937	u937	NN	NN	_	27	compound	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	monoblastic	monoblastic	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	13	nmod	_	_
28	,	,	,	,	_	2	punct	_	_
29	using	use	VBG	VBG	_	2	advcl	_	_
30	c-jun-specific	c-jun-specific	JJ	JJ	_	36	amod	_	_
31	antisense	antisense	JJ	JJ	_	36	amod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	AS	as	JJ	JJ	_	31	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	phosphorothioate	phosphorothioate	NN	NN	_	36	compound	_	_
36	oligonucleotides	oligonucleotide	NNS	NNS	_	29	dobj	_	_
37	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	selecting	select	VBG	VBG	_	12	advcl	_	_
3	the	the	DT	DT	_	9	det	_	_
4	most	most	RBS	RBS	_	5	advmod	_	_
5	specific	specific	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	potent	potent	JJ	JJ	_	5	conj	_	_
8	oligonucleotide	oligonucleotide	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	2	dobj	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	performed	perform	VBD	VBD	_	0	root	_	_
13	extensive	extensive	JJ	JJ	_	14	amod	_	_
14	analyses	analysis	NNS	NNS	_	12	dobj	_	_
15	for	for	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	specificity	specificity	NN	NN	_	14	nmod	_	_
19	between	between	IN	IN	_	21	case	_	_
20	all	all	DT	DT	_	21	det	_	_
21	candidates	candidate	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	c-jun	c-jun	NN	NN	_	25	compound	_	_
24	AS	as	JJ	JJ	_	25	amod	_	_
25	oligonucleotides	oligonucleotide	NNS	NNS	_	21	nmod	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	whole	whole	JJ	JJ	_	29	amod	_	_
29	sequences	sequence	NNS	NNS	_	21	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	GenBank	genbank	NN	NN	_	32	compound	_	_
32	database	database	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	12	punct	_	_
34	using	use	VBG	VBG	_	12	advcl	_	_
35	a	a	DT	DT	_	37	det	_	_
36	computer	computer	NN	NN	_	37	compound	_	_
37	program	program	NN	NN	_	34	dobj	_	_
38	.	.	.	.	_	12	punct	_	_

1	Among	among	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	20	20	CD	CD	_	5	nummod	_	_
4	selected	select	VBN	VBN	_	5	amod	_	_
5	oligonucleotides	oligonucleotide	NNS	NNS	_	17	nmod	_	_
6	,	,	,	,	_	17	punct	_	_
7	two	two	CD	CD	_	11	nummod	_	_
8	potent	potent	JJ	JJ	_	11	amod	_	_
9	15-mer	15-mer	JJ	JJ	_	11	amod	_	_
10	AS	as	JJ	JJ	_	11	amod	_	_
11	oligonucleotides	oligonucleotide	NNS	NNS	_	17	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	C-JUN	c-jun	NN	NN	_	15	compound	_	_
14	AS	as	JJ	JJ	_	15	amod	_	_
15	oligonucleotides	oligonucleotide	NNS	NNS	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	exhibited	exhibit	VBD	VBD	_	0	root	_	_
18	significant	significant	JJ	JJ	_	19	amod	_	_
19	inhibition	inhibition	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	growth	growth	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	dose-dependent	dose-dependent	JJ	JJ	_	26	amod	_	_
26	manner	manner	NN	NN	_	17	nmod	_	_
27	between	between	IN	IN	_	28	amod	_	_
28	2	2	CD	CD	_	31	nummod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	10	10	CD	CD	_	28	conj	_	_
31	microM	microm	NN	NN	_	26	dep	_	_
32	.	.	.	.	_	17	punct	_	_

1	Reverse	reverse	JJ	JJ	_	2	amod	_	_
2	transcription-PCR	transcription-pcr	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Western	western	NN	NN	_	6	compound	_	_
5	blot	blot	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	2	conj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	microM	microm	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	C-JUN	c-jun	NN	NN	_	14	compound	_	_
13	AS	as	JJ	JJ	_	14	amod	_	_
14	oligonucleotides	oligonucleotide	NNS	NNS	_	10	nmod	_	_
15	reduced	reduce	VBD	VBD	_	7	ccomp	_	_
16	c-jun	c-jun	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	at	at	IN	IN	_	24	case	_	_
19	both	both	CC	CC	_	24	cc:preconj	_	_
20	the	the	DT	DT	_	24	det	_	_
21	mRNA	mrna	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	protein	protein	NN	NN	_	21	conj	_	_
24	levels	level	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	More	more	RBR	RBR	_	2	advmod	_	_
2	importantly	importantly	RB	RB	_	7	advmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	C-JUN	c-jun	NN	NN	_	6	compound	_	_
5	AS	as	JJ	JJ	_	6	amod	_	_
6	oligonucleotides	oligonucleotide	NNS	NNS	_	7	nsubj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	distinct	distinct	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	7	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	markers	marker	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	PMA-induced	pma-induced	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	;	;	:	:	_	7	punct	_	_
17	the	the	DT	DT	_	20	det	_	_
18	C-JUN	c-jun	NN	NN	_	20	compound	_	_
19	AS	as	JJ	JJ	_	20	amod	_	_
20	oligonucleotides	oligonucleotide	NNS	NNS	_	21	nsubj	_	_
21	inhibited	inhibit	VBD	VBD	_	7	parataxis	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	adhesion	adhesion	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	21	punct	_	_
25	whereas	whereas	IN	IN	_	21	dep	_	_
26	they	they	PRP	PRP	_	29	nsubj	_	_
27	did	do	VBD	VBD	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	affect	affect	VB	VB	_	21	parataxis	_	_
30	another	another	DT	DT	_	31	det	_	_
31	marker	marker	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	differentiation	differentiation	NN	NN	_	31	nmod	_	_
34	,	,	,	,	_	31	punct	_	_
35	respiratory	respiratory	JJ	JJ	_	36	amod	_	_
36	burst	burst	NN	NN	_	31	appos	_	_
37	(	(	-LRB-	-LRB-	_	31	punct	_	_
38	measured	measure	VBN	VBN	_	31	acl	_	_
39	by	by	IN	IN	_	44	case	_	_
40	nitro	nitro	NN	NN	_	44	compound	_	_
41	blue	blue	JJ	JJ	_	44	amod	_	_
42	tetrazolium	tetrazolium	NN	NN	_	44	compound	_	_
43	reduction	reduction	NN	NN	_	44	compound	_	_
44	assay	assay	NN	NN	_	38	nmod	_	_
45	)	)	-RRB-	-RRB-	_	31	punct	_	_
46	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	critical	critical	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	c-jun	c-jun	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	PMA-induced	pma-induced	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	12	conj	_	_
17	but	but	CC	CC	_	12	cc	_	_
18	not	not	RB	RB	_	22	neg	_	_
19	in	in	IN	IN	_	22	case	_	_
20	PMA-induced	pma-induced	JJ	JJ	_	22	amod	_	_
21	respiratory	respiratory	JJ	JJ	_	22	amod	_	_
22	burst	burst	NN	NN	_	12	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	U937	u937	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	posttranscriptional	posttranscriptional	JJ	JJ	_	1	conj	_	_
4	regulation	regulation	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	8	case	_	_
6	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	anthracycline-induced	anthracycline-induced	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	erythroleukemic	erythroleukemic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Aclacinomycin	aclacinomycin	NN	NN	_	11	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	ACLA	acla	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	doxorubicin	doxorubicin	NN	NN	_	1	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	DOX	dox	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	used	use	VBN	VBN	_	0	root	_	_
12	at	at	IN	IN	_	14	case	_	_
13	subtoxic	subtoxic	JJ	JJ	_	14	amod	_	_
14	concentrations	concentration	NNS	NNS	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	11	xcomp	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	25	case	_	_
20	the	the	DT	DT	_	25	det	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	leukemic	leukemic	JJ	JJ	_	25	amod	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	line	line	NN	NN	_	25	compound	_	_
25	K562	k562	NN	NN	_	16	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	hemoglobinization	hemoglobinization	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	increased	increase	VBN	VBN	_	8	amod	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	genes	gene	NNS	NNS	_	8	nmod	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	gamma-globin	gamma-globin	NN	NN	_	15	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	porphobilinogen	porphobilinogen	NN	NN	_	12	conj	_	_
15	deaminase	deaminase	NN	NN	_	11	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PBGD	pbgd	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	an	a	DT	DT	_	21	det	_	_
21	enzyme	enzyme	NN	NN	_	15	appos	_	_
22	of	of	IN	IN	_	24	case	_	_
23	heme	heme	NN	NN	_	24	compound	_	_
24	synthesis	synthesis	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	8	advcl	_	_
3	run-on	run-on	JJ	JJ	_	4	amod	_	_
4	assays	assay	NNS	NNS	_	2	dobj	_	_
5	,	,	,	,	_	8	punct	_	_
6	ACLA	acla	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	induce	induce	VB	VB	_	8	xcomp	_	_
11	an	a	DT	DT	_	12	det	_	_
12	enhancement	enhancement	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	gamma-globin	gamma-globin	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	PBGD	pbgd	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	erythropoietin	erythropoietin	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	21	conj	_	_
27	,	,	,	,	_	21	punct	_	_
28	and	and	CC	CC	_	21	cc	_	_
29	GATA-1	gata-1	NN	NN	_	21	conj	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	29	dep	_	_
32	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	in	in	IN	IN	_	6	case	_	_
5	DOX-treated	dox-treated	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	15	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	rate	rate	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	unchanged	unchanged	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	comparison	comparison	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	control	control	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	inhibition	inhibition	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	actinomycin	actinomycin	NN	NN	_	10	compound	_	_
10	D	d	NN	NN	_	7	nmod	_	_
11	indicated	indicate	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	DOX	dox	NN	NN	_	14	nsubj	_	_
14	induced	induce	VBD	VBD	_	11	ccomp	_	_
15	an	a	DT	DT	_	17	det	_	_
16	increased	increase	VBN	VBN	_	17	amod	_	_
17	stability	stability	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	PBGD	pbgd	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	GATA-1	gata-1	NN	NN	_	19	conj	_	_
22	mRNAs	mrna	NNS	NNS	_	19	dep	_	_
23	,	,	,	,	_	14	punct	_	_
24	whereas	whereas	IN	IN	_	28	mark	_	_
25	ACLA	acla	NN	NN	_	28	nsubj	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	affect	affect	VB	VB	_	14	advcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	half-lives	half-life	NNS	NNS	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	these	these	DT	DT	_	33	det	_	_
33	mRNAs	mrna	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	Because	because	IN	IN	_	13	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	increase	increase	NN	NN	_	13	nsubjpass	_	_
4	in	in	IN	IN	_	8	case	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	mRNA	mrna	NN	NN	_	8	compound	_	_
7	steady-state	steady-state	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	anthracycline-treated	anthracycline-treated	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	inhibited	inhibit	VBN	VBN	_	18	advcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	cycloheximide	cycloheximide	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	this	this	DT	DT	_	18	nsubj	_	_
18	suggests	suggest	VBZ	VBZ	_	0	root	_	_
19	that	that	IN	IN	_	32	mark	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	32	nsubj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	ACLA-treated	acla-treated	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	mRNA	mrna	NN	NN	_	27	compound	_	_
27	stabilization	stabilization	NN	NN	_	21	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	DOX-treated	dox-treated	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	were	be	VBD	VBD	_	32	cop	_	_
32	dependent	dependent	JJ	JJ	_	18	ccomp	_	_
33	on	on	IN	IN	_	37	case	_	_
34	de	de	FW	FW	_	37	amod	_	_
35	novo	novo	FW	FW	_	34	dep	_	_
36	protein	protein	NN	NN	_	37	compound	_	_
37	synthesis	synthesis	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	18	punct	_	_

1	Finally	finally	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	GATA-1	gata-1	NN	NN	_	5	compound	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	level	level	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	increased	increase	VBN	VBN	_	7	xcomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	ACLA-treated	acla-treated	JJ	JJ	_	17	nmod	_	_
13	but	but	CC	CC	_	17	cc	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	in	in	IN	IN	_	16	case	_	_
16	DOX-treated	dox-treated	JJ	JJ	_	17	conj	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	anthracyclines	anthracycline	NNS	NNS	_	12	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	although	although	IN	IN	_	7	mark	_	_
6	closely	closely	RB	RB	_	7	advmod	_	_
7	related	related	JJ	JJ	_	12	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
10	structures	structure	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	12	punct	_	_
12	appeared	appear	VBD	VBD	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	act	act	VB	VB	_	12	xcomp	_	_
15	as	as	IN	IN	_	17	case	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	inducers	inducer	NNS	NNS	_	14	nmod	_	_
18	by	by	IN	IN	_	20	case	_	_
19	distinct	distinct	JJ	JJ	_	20	amod	_	_
20	mechanisms	mechanism	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Indeed	indeed	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	regulated	regulate	VBN	VBN	_	7	xcomp	_	_
11	transcriptionally	transcriptionally	RB	RB	_	13	advmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	ACLA	acla	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	mainly	mainly	RB	RB	_	16	advmod	_	_
16	posttranscriptionally	posttranscriptionally	RB	RB	_	18	advmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	DOX	dox	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	TAFII	tafii	NN	NN	_	9	nsubj	_	_
3	105	105	CD	CD	_	2	nummod	_	_
4	is	be	VBZ	VBZ	_	9	cop	_	_
5	a	a	DT	DT	_	9	det	_	_
6	cell	cell	NN	NN	_	7	nmod:npmod	_	_
7	type-specific	type-specific	JJ	JJ	_	9	amod	_	_
8	TFIID	tfiid	NN	NN	_	9	compound	_	_
9	subunit	subunit	NN	NN	_	0	root	_	_
10	related	related	JJ	JJ	_	9	amod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	hTAFII130	htafii130	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	characterized	characterize	VBD	VBD	_	0	root	_	_
4	Drosophila	drosophila	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	TAF	taf	NN	NN	_	4	conj	_	_
8	subunits	subunit	NNS	NNS	_	3	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	make	make	VBP	VBP	_	8	acl:relcl	_	_
11	up	up	RP	RP	_	10	compound:prt	_	_
12	the	the	DT	DT	_	15	det	_	_
13	core	core	NN	NN	_	15	compound	_	_
14	TFIID	tfiid	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	10	dobj	_	_
16	found	find	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	all	all	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	differentiated	differentiate	VBN	VBN	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	contain	contain	VBP	VBP	_	4	ccomp	_	_
10	a	a	DT	DT	_	13	det	_	_
11	novel	novel	JJ	JJ	_	13	amod	_	_
12	substoichiometric	substoichiometric	JJ	JJ	_	13	amod	_	_
13	TAF	taf	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	105	105	CD	CD	_	16	nummod	_	_
16	kDa	kda	NN	NN	_	13	nmod	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	found	find	VBN	VBN	_	13	acl	_	_
19	associated	associate	VBN	VBN	_	18	dep	_	_
20	with	with	IN	IN	_	21	case	_	_
21	TFIID	tfiid	NN	NN	_	19	nmod	_	_
22	isolated	isolate	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	26	case	_	_
24	other	other	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	types	type	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cDNA	cdna	NN	NN	_	4	compound	_	_
3	encoding	encoding	NN	NN	_	4	compound	_	_
4	hTAFII105	htafii105	NN	NN	_	5	nsubj	_	_
5	reveals	reveal	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	10	det	_	_
7	highly	highly	RB	RB	_	8	advmod	_	_
8	conserved	conserve	VBN	VBN	_	10	amod	_	_
9	C-terminal	c-terminal	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	5	dobj	_	_
11	shared	share	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	hTAFII130	htafii130	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	oTAFII110	otafii110	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	5	punct	_	_
17	while	while	IN	IN	_	23	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	N-terminal	n-terminal	JJ	JJ	_	21	amod	_	_
20	coactivator	coactivator	NN	NN	_	21	compound	_	_
21	domain	domain	NN	NN	_	23	nsubj	_	_
22	has	have	VBZ	VBZ	_	23	aux	_	_
23	diverged	diverge	VBN	VBN	_	5	advcl	_	_
24	significantly	significantly	RB	RB	_	23	advmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	tested	test	VBN	VBN	_	2	acl	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	TAFII105	tafii105	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	4	punct	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	only	only	RB	RB	_	11	advmod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	12	nsubj	_	_
12	contain	contain	VBP	VBP	_	4	conj	_	_
13	significant	significant	JJ	JJ	_	14	amod	_	_
14	levels	level	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	protein	protein	NN	NN	_	14	nmod	_	_
17	associated	associate	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	TFIID	tfiid	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	overexpression	overexpression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	hTAFII105	htafii105	NN	NN	_	2	nmod	_	_
5	selectively	selectively	RB	RB	_	6	advmod	_	_
6	squelches	squelch	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	some	some	DT	DT	_	11	det	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	properties	property	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	TAFII105	tafii105	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	cell	cell	NN	NN	_	9	nmod:npmod	_	_
9	type-specific	type-specific	JJ	JJ	_	10	amod	_	_
10	subunit	subunit	NN	NN	_	3	ccomp	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TFIID	tfiid	NN	NN	_	10	nmod	_	_
13	that	that	WDT	WDT	_	16	nsubj	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	responsible	responsible	JJ	JJ	_	10	acl:relcl	_	_
17	for	for	IN	IN	_	18	mark	_	_
18	mediating	mediate	VBG	VBG	_	16	advcl	_	_
19	transcription	transcription	NN	NN	_	18	dobj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	subset	subset	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	activators	activator	NNS	NNS	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Uneven	uneven	JJ	JJ	_	3	amod	_	_
2	X	x	NN	NN	_	3	compound	_	_
3	inactivation	inactivation	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	female	female	JJ	JJ	_	9	amod	_	_
7	monozygotic	monozygotic	JJ	JJ	_	9	amod	_	_
8	twin	twin	JJ	JJ	_	9	amod	_	_
9	pair	pair	NN	NN	_	3	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	Fabry	fabry	NN	NN	_	12	compound	_	_
12	disease	disease	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	discordant	discordant	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	3	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	novel	novel	JJ	JJ	_	19	amod	_	_
19	mutation	mutation	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	alpha-galactosidase	alpha-galactosidase	NN	NN	_	24	compound	_	_
23	A	a	NN	NN	_	24	compound	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	two	two	CD	CD	_	9	nummod	_	_
4	female	female	JJ	JJ	_	9	amod	_	_
5	monozygotic	monozygotic	JJ	JJ	_	9	amod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MZ	mz	JJ	JJ	_	5	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	twins	twin	NNS	NNS	_	2	dobj	_	_
10	heterozygous	heterozygous	JJ	JJ	_	9	amod	_	_
11	for	for	IN	IN	_	13	case	_	_
12	Fabry	fabry	NN	NN	_	13	compound	_	_
13	disease	disease	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	an	a	DT	DT	_	18	det	_	_
16	X	x	NN	NN	_	17	dep	_	_
17	linked	link	VBN	VBN	_	18	amod	_	_
18	disorder	disorder	NN	NN	_	13	appos	_	_
19	resulting	result	VBG	VBG	_	18	acl	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	deficient	deficient	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	alpha-galactosidase	alpha-galactosidase	NN	NN	_	26	compound	_	_
26	A	a	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	While	while	IN	IN	_	8	mark	_	_
2	one	one	CD	CD	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	twins	twin	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	clinically	clinically	RB	RB	_	8	advmod	_	_
8	affected	affect	VBN	VBN	_	13	advcl	_	_
9	,	,	,	,	_	13	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	other	other	JJ	JJ	_	13	nsubj	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	asymptomatic	asymptomatic	JJ	JJ	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Enzymatic	enzymatic	JJ	JJ	_	2	amod	_	_
2	assay	assay	NN	NN	_	28	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	alpha-galactosidase	alpha-galactosidase	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	leucocytes	leucocyte	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	skin	skin	NN	NN	_	10	compound	_	_
10	fibroblasts	fibroblast	NNS	NNS	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	Epstein-Barr	epstein-barr	JJ	JJ	_	13	amod	_	_
13	virus	virus	NN	NN	_	14	dep	_	_
14	transformed	transform	VBD	VBD	_	17	amod	_	_
15	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	7	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	hair	hair	NN	NN	_	21	compound	_	_
21	follicles	follicle	NNS	NNS	_	7	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	twins	twin	NNS	NNS	_	7	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
27	parents	parent	NNS	NNS	_	24	conj	_	_
28	confirmed	confirm	VBD	VBD	_	0	root	_	_
29	the	the	DT	DT	_	31	det	_	_
30	heterozygous	heterozygous	JJ	JJ	_	31	amod	_	_
31	status	status	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	twins	twin	NNS	NNS	_	31	nmod	_	_
35	and	and	CC	CC	_	28	cc	_	_
36	indicated	indicate	VBD	VBD	_	28	conj	_	_
37	that	that	IN	IN	_	41	mark	_	_
38	Fabry	fabry	NN	NN	_	39	compound	_	_
39	disease	disease	NN	NN	_	41	nsubj	_	_
40	had	have	VBD	VBD	_	41	aux	_	_
41	occurred	occur	VBN	VBN	_	36	ccomp	_	_
42	as	as	IN	IN	_	44	case	_	_
43	a	a	DT	DT	_	44	det	_	_
44	result	result	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	49	case	_	_
46	a	a	DT	DT	_	49	det	_	_
47	de	de	FW	FW	_	49	amod	_	_
48	novo	novo	FW	FW	_	47	dep	_	_
49	mutation	mutation	NN	NN	_	44	nmod	_	_
50	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	son	son	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	unaffected	unaffected	JJ	JJ	_	7	amod	_	_
6	twin	twin	NN	NN	_	7	compound	_	_
7	sister	sister	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	hemizygous	hemizygous	JJ	JJ	_	9	xcomp	_	_
13	.	.	.	.	_	9	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	alpha-galactosidase	alpha-galactosidase	NN	NN	_	7	compound	_	_
6	A	a	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	permitted	permit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	identification	identification	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	17	case	_	_
12	an	a	DT	DT	_	17	det	_	_
13	as	as	RB	RB	_	14	advmod	_	_
14	yet	yet	RB	RB	_	15	advmod	_	_
15	undescribed	undescribed	JJ	JJ	_	17	amod	_	_
16	point	point	NN	NN	_	17	compound	_	_
17	mutation	mutation	NN	NN	_	10	nmod	_	_
18	at	at	IN	IN	_	19	case	_	_
19	position	position	NN	NN	_	17	nmod	_	_
20	10182	10182	CD	CD	_	19	nummod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	exon	exon	NN	NN	_	19	nmod	_	_
23	5	5	CD	CD	_	22	nummod	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	causes	cause	VBZ	VBZ	_	17	acl:relcl	_	_
26	an	a	DT	DT	_	30	det	_	_
27	Asp	asp	NN	NN	_	30	compound	_	_
28	to	to	TO	TO	_	27	dep	_	_
29	Asn	asn	NN	NN	_	27	dep	_	_
30	substitution	substitution	NN	NN	_	25	dobj	_	_
31	at	at	IN	IN	_	32	case	_	_
32	codon	codon	NN	NN	_	30	nmod	_	_
33	231	231	CD	CD	_	32	nummod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Single	single	JJ	JJ	_	4	amod	_	_
2	strand	strand	NN	NN	_	4	compound	_	_
3	conformation	conformation	NN	NN	_	4	compound	_	_
4	polymorphism	polymorphism	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SSCP	sscp	NN	NN	_	8	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	analysis	analysis	NN	NN	_	10	nsubj	_	_
9	again	again	RB	RB	_	10	advmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	heterozygous	heterozygous	JJ	JJ	_	13	amod	_	_
13	status	status	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	twins	twin	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	a	a	DT	DT	_	20	det	_	_
19	normal	normal	JJ	JJ	_	20	amod	_	_
20	pattern	pattern	NN	NN	_	13	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	parents	parent	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	basis	basis	NN	NN	_	16	nsubjpass	_	_
3	for	for	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	discordant	discordant	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	this	this	DT	DT	_	11	det	_	_
9	d	d	FW	FW	_	11	amod	_	_
10	novo	novo	FW	FW	_	9	dep	_	_
11	mutation	mutation	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	twins	twin	NNS	NNS	_	11	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	investigated	investigate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	studying	study	VBG	VBG	_	16	advcl	_	_
19	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
20	X	x	NN	NN	_	22	compound	_	_
21	inactivation	inactivation	NN	NN	_	22	compound	_	_
22	status	status	NN	NN	_	18	dobj	_	_
23	.	.	.	.	_	16	punct	_	_

1	Analysis	analysis	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	inactive	inactive	JJ	JJ	_	5	amod	_	_
5	X	x	NN	NN	_	6	nmod:npmod	_	_
6	specific	specific	JJ	JJ	_	7	amod	_	_
7	methylation	methylation	NN	NN	_	1	nmod	_	_
8	at	at	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	androgen	androgen	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	unbalanced	unbalanced	JJ	JJ	_	15	amod	_	_
15	inactivation	inactivation	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	twins	twin	NNS	NNS	_	20	nmod:poss	_	_
19	'	'	POS	POS	_	18	case	_	_
20	fibroblasts	fibroblast	NNS	NNS	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	in	in	IN	IN	_	24	case	_	_
23	opposite	opposite	JJ	JJ	_	24	amod	_	_
24	directions	direction	NNS	NNS	_	20	conj	_	_
25	.	.	.	.	_	13	punct	_	_

1	While	while	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	6	det	_	_
3	maternally	maternally	RB	RB	_	4	advmod	_	_
4	derived	derive	VBN	VBN	_	6	amod	_	_
5	X	x	NN	NN	_	6	compound	_	_
6	chromosome	chromosome	NN	NN	_	9	nsubj	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	preferentially	preferentially	RB	RB	_	9	advmod	_	_
9	active	active	JJ	JJ	_	20	advcl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	asymptomatic	asymptomatic	JJ	JJ	_	13	amod	_	_
13	twin	twin	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	20	punct	_	_
15	the	the	DT	DT	_	18	det	_	_
16	paternal	paternal	JJ	JJ	_	18	amod	_	_
17	X	x	NN	NN	_	18	compound	_	_
18	chromosome	chromosome	NN	NN	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	active	active	JJ	JJ	_	0	root	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	other	other	JJ	JJ	_	26	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	affected	affect	VBN	VBN	_	23	dep	_	_
26	twin	twin	NN	NN	_	20	nmod	_	_
27	and	and	CC	CC	_	20	cc	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	found	find	VBN	VBN	_	20	conj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	her	she	PRP$	PRP$	_	33	nmod:poss	_	_
32	hemizygotic	hemizygotic	JJ	JJ	_	33	amod	_	_
33	nephew	nephew	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	paternal	paternal	JJ	JJ	_	8	amod	_	_
7	X	x	NN	NN	_	8	compound	_	_
8	chromosome	chromosome	NN	NN	_	9	nsubj	_	_
9	carries	carry	VBZ	VBZ	_	3	ccomp	_	_
10	the	the	DT	DT	_	15	det	_	_
11	de	de	FW	FW	_	15	amod	_	_
12	novo	novo	FW	FW	_	11	dep	_	_
13	alpha-galactosidase	alpha-galactosidase	NN	NN	_	15	compound	_	_
14	A	a	NN	NN	_	15	compound	_	_
15	mutation	mutation	NN	NN	_	9	dobj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	uneven	uneven	JJ	JJ	_	20	amod	_	_
19	X	x	NN	NN	_	20	compound	_	_
20	inactivation	inactivation	NN	NN	_	24	nsubj	_	_
21	is	be	VBZ	VBZ	_	24	cop	_	_
22	the	the	DT	DT	_	24	det	_	_
23	underlying	underlie	VBG	VBG	_	24	amod	_	_
24	mechanism	mechanism	NN	NN	_	9	conj	_	_
25	for	for	IN	IN	_	27	case	_	_
26	disease	disease	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	in	in	IN	IN	_	34	case	_	_
29	this	this	DT	DT	_	34	det	_	_
30	novel	novel	JJ	JJ	_	34	amod	_	_
31	female	female	NN	NN	_	34	compound	_	_
32	MZ	mz	JJ	JJ	_	34	amod	_	_
33	twin	twin	NN	NN	_	34	compound	_	_
34	pair	pair	NN	NN	_	27	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	the	the	DT	DT	_	6	det	_	_
4	first	first	JJ	JJ	_	6	amod	_	_
5	documented	document	VBN	VBN	_	6	amod	_	_
6	case	case	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	female	female	JJ	JJ	_	9	amod	_	_
9	twins	twin	NNS	NNS	_	6	nmod	_	_
10	discordant	discordant	JJ	JJ	_	9	amod	_	_
11	for	for	IN	IN	_	13	case	_	_
12	Fabry	fabry	NN	NN	_	13	compound	_	_
13	disease	disease	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Signaling	signaling	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	related	related	JJ	JJ	_	6	amod	_	_
6	cytokines	cytokine	NNS	NNS	_	3	conj	_	_
7	:	:	:	:	_	1	punct	_	_
8	JAKs	jak	NNS	NNS	_	1	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	STATs	stats	NNS	NNS	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	relationship	relationship	NN	NN	_	8	conj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	32	nsubj	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	bind	bind	VBP	VBP	_	1	acl:relcl	_	_
4	to	to	TO	TO	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	interleukin-2	interleukin-2	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-2	il-2	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	receptor	receptor	NN	NN	_	3	nmod	_	_
11	common	common	JJ	JJ	_	10	amod	_	_
12	gamma	gamma	NN	NN	_	13	compound	_	_
13	chain	chain	NN	NN	_	10	dep	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	gamma	gamma	NN	NN	_	16	compound	_	_
16	c	c	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	10	punct	_	_
19	including	include	VBG	VBG	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	10	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	IL-4	il-4	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	IL-7	il-7	NN	NN	_	20	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	IL-9	il-9	NN	NN	_	20	conj	_	_
27	,	,	,	,	_	20	punct	_	_
28	and	and	CC	CC	_	20	cc	_	_
29	IL-15	il-15	NN	NN	_	20	conj	_	_
30	,	,	,	,	_	10	punct	_	_
31	are	be	VBP	VBP	_	32	cop	_	_
32	important	important	JJ	JJ	_	0	root	_	_
33	for	for	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	growth	growth	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	differentiation	differentiation	NN	NN	_	35	conj	_	_
38	of	of	IN	IN	_	42	case	_	_
39	T	t	NN	NN	_	42	compound	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	B	b	NN	NN	_	39	conj	_	_
42	lymphocytes	lymphocyte	NNS	NNS	_	35	nmod	_	_
43	,	,	,	,	_	42	punct	_	_
44	natural	natural	JJ	JJ	_	46	amod	_	_
45	killer	killer	NN	NN	_	46	compound	_	_
46	cells	cell	NNS	NNS	_	42	conj	_	_
47	,	,	,	,	_	42	punct	_	_
48	macrophages	macrophage	NNS	NNS	_	42	conj	_	_
49	,	,	,	,	_	42	punct	_	_
50	and	and	CC	CC	_	42	cc	_	_
51	monoctyes	monoctye	NNS	NNS	_	42	conj	_	_
52	.	.	.	.	_	32	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	overlapping	overlap	VBG	VBG	_	6	amod	_	_
5	biological	biological	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	3	dobj	_	_
7	that	that	WDT	WDT	_	10	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	part	part	NN	NN	_	10	nmod	_	_
10	result	result	VBP	VBP	_	6	acl:relcl	_	_
11	from	from	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	use	use	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	shared	share	VBN	VBN	_	20	amod	_	_
17	receptor	receptor	NN	NN	_	20	compound	_	_
18	subunit	subunit	NN	NN	_	20	compound	_	_
19	gamma	gamma	NN	NN	_	20	compound	_	_
20	c	c	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	it	it	PRP	PRP	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	become	become	VBN	VBN	_	0	root	_	_
5	clear	clear	JJ	JJ	_	4	xcomp	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	these	these	DT	DT	_	8	det	_	_
8	cytokines	cytokine	NNS	NNS	_	9	nsubj	_	_
9	activate	activate	VBP	VBP	_	4	ccomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	important	important	JJ	JJ	_	16	amod	_	_
14	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
15	signaling	signal	VBG	VBG	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Janus	janus	NN	NN	_	21	compound	_	_
21	kinases	kinase	NNS	NNS	_	16	nmod	_	_
22	JAK1	jak1	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	JAK3	jak3	NN	NN	_	22	conj	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	members	member	NNS	NNS	_	21	conj	_	_
27	of	of	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	family	family	NN	NN	_	26	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	signal	signal	NN	NN	_	31	nmod	_	_
34	transducers	transducer	NNS	NNS	_	33	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	activators	activator	NNS	NNS	_	34	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	transcription	transcription	NN	NN	_	33	nmod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	STATs	stats	NNS	NNS	_	33	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	discovery	discovery	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	pathways	pathway	NNS	NNS	_	2	nmod	_	_
7	has	have	VBZ	VBZ	_	8	aux	_	_
8	led	lead	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	important	important	JJ	JJ	_	12	amod	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	insights	insight	NNS	NNS	_	8	nmod	_	_
13	into	into	IN	IN	_	15	case	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	role	role	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	lymphocyte	lymphocyte	NN	NN	_	18	compound	_	_
18	maturation	maturation	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	as	as	IN	IN	_	23	mark	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	has	have	VBZ	VBZ	_	23	aux	_	_
23	emerged	emerge	VBN	VBN	_	8	advcl	_	_
24	that	that	IN	IN	_	35	mark	_	_
25	mutations	mutation	NNS	NNS	_	35	nsubj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	genes	gene	NNS	NNS	_	25	nmod	_	_
29	encoding	encode	VBG	VBG	_	28	acl	_	_
30	both	both	CC	CC	_	32	cc:preconj	_	_
31	gamma	gamma	NN	NN	_	32	compound	_	_
32	c	c	NN	NN	_	29	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	JAK3	jak3	NN	NN	_	32	conj	_	_
35	result	result	VBP	VBP	_	23	ccomp	_	_
36	in	in	IN	IN	_	38	case	_	_
37	similar	similar	JJ	JJ	_	38	amod	_	_
38	forms	form	NNS	NNS	_	35	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	severe	severe	JJ	JJ	_	42	amod	_	_
41	combined	combined	JJ	JJ	_	42	amod	_	_
42	immunodeficiency	immunodeficiency	NN	NN	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	SCID	scid	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	examine	examine	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	structure	structure	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	function	function	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	7	conj	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	regulation	regulation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	discuss	discuss	VBP	VBP	_	0	root	_	_
5	recent	recent	JJ	JJ	_	6	amod	_	_
6	advances	advance	NNS	NNS	_	4	dobj	_	_
7	that	that	WDT	WDT	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	led	lead	VBN	VBN	_	6	acl:relcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	better	better	JJR	JJR	_	13	amod	_	_
13	understanding	understanding	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	mark	_	_
15	how	how	WRB	WRB	_	17	advmod	_	_
16	cytokines	cytokine	NNS	NNS	_	17	nsubj	_	_
17	elicit	elicit	VBP	VBP	_	13	acl	_	_
18	intracellular	intracellular	JJ	JJ	_	19	amod	_	_
19	responses	response	NNS	NNS	_	17	dobj	_	_
20	,	,	,	,	_	17	punct	_	_
21	as	as	RB	RB	_	25	advmod	_	_
22	well	well	RB	RB	_	25	advmod	_	_
23	as	as	IN	IN	_	25	case	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	role	role	NN	NN	_	17	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	normal	normal	JJ	JJ	_	29	amod	_	_
28	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
29	development	development	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	murine	murine	JJ	JJ	_	10	amod	_	_
7	B-cell	b-cell	NN	NN	_	10	compound	_	_
8	specific	specific	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	coactivator	coactivator	NN	NN	_	1	nmod	_	_
11	Bob1	bob1	NN	NN	_	10	dep	_	_
12	.	.	.	.	_	1	punct	_	_

1	From	from	IN	IN	_	5	case	_	_
2	a	a	DT	DT	_	5	det	_	_
3	murine	murine	JJ	JJ	_	5	amod	_	_
4	B-cell	b-cell	NN	NN	_	5	compound	_	_
5	cDNA-library	cdna-library	NN	NN	_	8	nmod	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	cloned	clone	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	cDNA	cdna	NN	NN	_	8	dobj	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	16	det	_	_
13	murine	murine	JJ	JJ	_	16	amod	_	_
14	B-cell	b-cell	NN	NN	_	16	compound	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	coactivator	coactivator	NN	NN	_	11	dobj	_	_
17	mBob1	mbob1	NN	NN	_	16	dep	_	_
18	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	the	the	DT	DT	_	6	det	_	_
5	murine	murine	JJ	JJ	_	6	amod	_	_
6	homologue	homologue	NN	NN	_	0	root	_	_
7	to	to	TO	TO	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	recently	recently	RB	RB	_	10	advmod	_	_
10	described	describe	VBN	VBN	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	coactivator	coactivator	NN	NN	_	13	compound	_	_
13	Bob1	bob1	NN	NN	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	hBob1	hbob1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	referred	refer	VBN	VBN	_	13	acl	_	_
20	to	to	TO	TO	_	19	nmod	_	_
21	as	as	IN	IN	_	22	case	_	_
22	OBF-1	obf-1	NN	NN	_	19	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	OCA-B	oca-b	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	genomic	genomic	JJ	JJ	_	8	amod	_	_
7	mBob1	mbob1	NN	NN	_	8	compound	_	_
8	clone	clone	NN	NN	_	4	dobj	_	_
9	.	.	.	.	_	4	punct	_	_

1	Analysis	analysis	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	intron-exon	intron-exon	JJ	JJ	_	5	amod	_	_
5	structure	structure	NN	NN	_	1	nmod	_	_
6	has	have	VBZ	VBZ	_	7	aux	_	_
7	allowed	allow	VBN	VBN	_	0	root	_	_
8	identification	identification	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	C-terminal	c-terminal	JJ	JJ	_	13	amod	_	_
12	splice	splice	NN	NN	_	13	compound	_	_
13	variant	variant	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	mBob1	mbob1	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	B-cell	b-cell	NN	NN	_	4	nmod:npmod	_	_
4	restricted	restricted	JJ	JJ	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	4	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	all	all	DT	DT	_	12	det	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	8	nmod	_	_
13	representing	represent	VBG	VBG	_	12	acl	_	_
14	different	different	JJ	JJ	_	15	amod	_	_
15	stages	stage	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	B-cell	b-cell	NN	NN	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	mBob1	mbob1	NN	NN	_	2	nsubj	_	_
2	interacts	interact	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	octamer	octamer	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	2	nmod	_	_
8	Oct-1	oct-1	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Oct-2	oct-2	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	stimulates	stimulate	VBZ	VBZ	_	2	conj	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	mediated	mediate	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Eosinophil	eosinophil	NN	NN	_	2	compound	_	_
2	priming	priming	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	cytokines	cytokine	NNS	NNS	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	from	from	IN	IN	_	8	case	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	signal	signal	NN	NN	_	2	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	in	in	FW	FW	_	12	amod	_	_
11	vivo	vivo	FW	FW	_	10	dep	_	_
12	modulation	modulation	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	2	nsubj	_	_
2	play	play	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	effector	effector	NN	NN	_	9	compound	_	_
9	phase	phase	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	allergic	allergic	JJ	JJ	_	12	amod	_	_
12	inflammation	inflammation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	focus	focus	VB	VB	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	conversion	conversion	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	unprimed	unprimed	JJ	JJ	_	12	amod	_	_
11	eosinophil	eosinophil	NN	NN	_	12	compound	_	_
12	phenotype	phenotype	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
16	blood	blood	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	individuals	individual	NNS	NNS	_	16	nmod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	primed	primed	JJ	JJ	_	23	amod	_	_
23	phenotype	phenotype	NN	NN	_	7	nmod	_	_
24	found	find	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	peripheral	peripheral	JJ	JJ	_	28	amod	_	_
28	blood	blood	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	tissues	tissue	NNS	NNS	_	28	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	allergic	allergic	JJ	JJ	_	33	amod	_	_
33	patients	patient	NNS	NNS	_	28	nmod	_	_
34	,	,	,	,	_	7	punct	_	_
35	a	a	DT	DT	_	36	det	_	_
36	phenomenon	phenomenon	NN	NN	_	7	appos	_	_
37	called	call	VBN	VBN	_	36	acl	_	_
38	priming	priming	NN	NN	_	37	xcomp	_	_
39	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	15	nsubjpass	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	signals	signal	NNS	NNS	_	2	nmod	_	_
6	initiated	initiate	VBN	VBN	_	5	acl	_	_
7	after	after	IN	IN	_	10	case	_	_
8	cytokine	cytokine	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	on	on	IN	IN	_	12	case	_	_
12	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
13	will	will	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	reviewed	review	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	steroid	steroid	NN	NN	_	5	compound	_	_
5	action	action	NN	NN	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	a	a	DT	DT	_	9	det	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	type	type	NN	NN	_	2	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cross-talk	cross-talk	NN	NN	_	9	nmod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	13	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	widespread	widespread	JJ	JJ	_	4	amod	_	_
4	use	use	NN	NN	_	34	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	glucocorticoids	glucocorticoid	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	treatment	treatment	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	diseases	disease	NNS	NNS	_	9	nmod	_	_
12	characterized	characterize	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	inflammation	inflammation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	34	punct	_	_
16	the	the	DT	DT	_	20	det	_	_
17	molecular	molecular	JJ	JJ	_	20	amod	_	_
18	mechanism	mechanism	NN	NN	_	20	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	s	s	NNS	NNS	_	34	nsubj	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	by	by	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	26	nmod	_	_
24	these	these	DT	DT	_	25	det	_	_
25	hormones	hormone	NNS	NNS	_	26	nsubj	_	_
26	exert	exert	VBP	VBP	_	20	acl:relcl	_	_
27	this	this	DT	DT	_	29	det	_	_
28	beneficial	beneficial	JJ	JJ	_	29	amod	_	_
29	effect	effect	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	26	nmod	_	_
32	with	with	IN	IN	_	33	case	_	_
33	asthma	asthma	NN	NN	_	31	nmod	_	_
34	remains	remain	VBZ	VBZ	_	0	root	_	_
35	to	to	TO	TO	_	37	mark	_	_
36	be	be	VB	VB	_	37	auxpass	_	_
37	elucidated	elucidate	VBN	VBN	_	34	xcomp	_	_
38	.	.	.	.	_	34	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	studied	study	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	intercellular	intercellular	JJ	JJ	_	12	amod	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecule-1	molecule-1	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	ICAM-1	icam-1	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	as	as	IN	IN	_	20	mark	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecules	molecule	NNS	NNS	_	20	nsubj	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	likely	likely	JJ	JJ	_	5	advcl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	play	play	VB	VB	_	20	xcomp	_	_
23	a	a	DT	DT	_	25	det	_	_
24	causal	causal	JJ	JJ	_	25	amod	_	_
25	role	role	NN	NN	_	22	dobj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	inflammation	inflammation	NN	NN	_	22	nmod	_	_
28	in	in	IN	IN	_	29	mark	_	_
29	promoting	promote	VBG	VBG	_	22	advcl	_	_
30	cell-cell	cell-cell	JJ	JJ	_	33	amod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	cell-matrix	cell-matrix	JJ	JJ	_	30	conj	_	_
33	interactions	interaction	NNS	NNS	_	29	dobj	_	_
34	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	monocytic	monocytic	JJ	JJ	_	20	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	U937	u937	NN	NN	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	a	a	DT	DT	_	13	det	_	_
12	bronchial	bronchial	JJ	JJ	_	13	dep	_	_
13	epithelial	epithelial	NN	NN	_	6	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	H292	h292	NN	NN	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	cell-line	cell-line	JJ	JJ	_	6	dep	_	_
18	dexamethasone	dexamethasone	NN	NN	_	20	nsubj	_	_
19	strongly	strongly	RB	RB	_	20	advmod	_	_
20	suppressed	suppress	VBD	VBD	_	2	ccomp	_	_
21	basal	basal	JJ	JJ	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	induced	induce	VBN	VBN	_	21	conj	_	_
24	ICAM-1	icam-1	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	20	dobj	_	_
26	.	.	.	.	_	2	punct	_	_

1	Subsequent	subsequent	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	ICAM-1	icam-1	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	2	nmod	_	_
8	has	have	VBZ	VBZ	_	9	aux	_	_
9	revealed	reveal	VBN	VBN	_	0	root	_	_
10	that	that	IN	IN	_	24	mark	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	12-O-tetradecanoylphorbol	12-o-tetradecanoylphorbol	NN	NN	_	13	compound	_	_
13	13-acetate	13-acetate	NN	NN	_	24	nsubj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TPA	tpa	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	tumour	tumour	NN	NN	_	20	compound	_	_
19	necrosis	necrosis	NN	NN	_	20	compound	_	_
20	factor-alpha	factor-alpha	NN	NN	_	13	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	upregulate	upregulate	VBP	VBP	_	9	ccomp	_	_
25	ICAM-1	icam-1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	through	through	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	24	nmod	_	_
30	of	of	IN	IN	_	39	case	_	_
31	a	a	DT	DT	_	39	det	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	factor	factor	NN	NN	_	39	compound	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	target	target	NN	NN	_	39	compound	_	_
39	sequence	sequence	NN	NN	_	29	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	TGGAAATTCC	tggaaattcc	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	9	punct	_	_

1	No	no	DT	DT	_	4	neg	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	recognition	recognition	NN	NN	_	4	compound	_	_
4	sequences	sequence	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	this	this	DT	DT	_	10	det	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	dexamethasone	dexamethasone	NN	NN	_	15	nsubj	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	still	still	RB	RB	_	15	advmod	_	_
15	able	able	JJ	JJ	_	6	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	repress	repress	VB	VB	_	15	xcomp	_	_
18	transcription	transcription	NN	NN	_	17	dobj	_	_
19	when	when	WRB	WRB	_	26	advmod	_	_
20	the	the	DT	DT	_	24	det	_	_
21	multimerized	multimerized	JJ	JJ	_	24	amod	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	transactivated	transactivate	VBN	VBN	_	15	advcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	TNF-alpha	tnf-alpha	NN	NN	_	26	nmod	_	_
29	upon	upon	IN	IN	_	30	case	_	_
30	transfection	transfection	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	293	293	CD	CD	_	33	nummod	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	20	nsubj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
12	factor-kappa	factor-kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	9	conj	_	_
15	is	be	VBZ	VBZ	_	20	cop	_	_
16	at	at	IN	IN	_	20	advmod	_	_
17	least	least	JJS	JJS	_	16	mwe	_	_
18	a	a	DT	DT	_	20	det	_	_
19	partial	partial	JJ	JJ	_	20	amod	_	_
20	explanation	explanation	NN	NN	_	2	ccomp	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	effects	effect	NNS	NNS	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	hormone	hormone	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	inflammatory	inflammatory	JJ	JJ	_	29	amod	_	_
29	diseases	disease	NNS	NNS	_	23	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	suppression	suppression	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	function	function	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NF(kappa)B	nf(kappa)b	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	conj	_	_
10	by	by	IN	IN	_	13	case	_	_
11	serine	serine	NN	NN	_	13	compound	_	_
12	protease	protease	NN	NN	_	13	compound	_	_
13	inhibitors	inhibitor	NNS	NNS	_	2	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	blocked	block	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	N-acetylcysteine	n-acetylcysteine	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	23	nsubjpass	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	N-acetylcysteine	n-acetylcysteine	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NAC	nac	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	enhances	enhance	VBZ	VBZ	_	2	ccomp	_	_
9	the	the	DT	DT	_	11	det	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	level	level	NN	NN	_	11	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF(kappa)B	nf(kappa)b	NN	NN	_	19	nmod	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	presented	present	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	NAC	nac	NN	NN	_	5	nsubj	_	_
5	blocks	block	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	suppression	suppression	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	mitogenesis	mitogenesis	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	conj	_	_
15	by	by	IN	IN	_	17	case	_	_
16	protease	protease	NN	NN	_	17	compound	_	_
17	inhibitors	inhibitor	NNS	NNS	_	5	nmod	_	_
18	such	such	JJ	JJ	_	22	case	_	_
19	as	as	IN	IN	_	18	mwe	_	_
20	N-tosylphenylalanine	n-tosylphenylalanine	NN	NN	_	22	compound	_	_
21	chloromethyl	chloromethyl	NN	NN	_	22	compound	_	_
22	ketone	ketone	NN	NN	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TPCK	tpck	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proliferative	proliferative	JJ	JJ	_	3	amod	_	_
3	responses	response	NNS	NNS	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	purified	purify	VBN	VBN	_	10	amod	_	_
6	CD4+	cd4+	JJ	JJ	_	10	amod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	CD8+	cd8+	JJ	JJ	_	6	conj	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	suppressed	suppress	VBN	VBN	_	0	root	_	_
13	more	more	RBR	RBR	_	14	advmod	_	_
14	strongly	strongly	RB	RB	_	12	advmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	TPCK	tpck	NN	NN	_	12	nmod	_	_
17	when	when	WRB	WRB	_	26	advmod	_	_
18	anti-CD28	anti-cd28	NN	NN	_	26	nsubjpass	_	_
19	rather	rather	RB	RB	_	18	cc	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	the	the	DT	DT	_	24	det	_	_
22	phorbol	phorbol	NN	NN	_	24	compound	_	_
23	ester	ester	NN	NN	_	24	compound	_	_
24	PMA	pma	NN	NN	_	18	conj	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	used	use	VBN	VBN	_	12	advcl	_	_
27	as	as	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	mitogenic	mitogenic	JJ	JJ	_	30	amod	_	_
30	coactivator	coactivator	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Cytokine	cytokine	NN	NN	_	9	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-2	il-2	NN	NN	_	1	dep	_	_
4	,	,	,	,	_	3	punct	_	_
5	IL-6	il-6	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	INF-gamma	inf-gamma	NN	NN	_	3	appos	_	_
8	)	)	-RRB-	-RRB-	_	3	punct	_	_
9	production	production	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	95-100	95-100	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	11	dobj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	concentrations	concentration	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	TPCK	tpck	NN	NN	_	15	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	totally	totally	RB	RB	_	20	advmod	_	_
20	suppress	suppress	VB	VB	_	17	acl:relcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	mitogenesis	mitogenesis	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	CD4+	cd4+	JJ	JJ	_	27	amod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	CD8+	cd8+	JJ	JJ	_	24	conj	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Using	use	VBG	VBG	_	8	advcl	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	find	find	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	TPCK	tpck	NN	NN	_	12	nsubj	_	_
11	virtually	virtually	RB	RB	_	12	advmod	_	_
12	abolishes	abolish	VBZ	VBZ	_	8	ccomp	_	_
13	(	(	-LRB-	-LRB-	_	12	punct	_	_
14	to	to	TO	TO	_	18	case	_	_
15	less	less	JJR	JJR	_	17	advmod	_	_
16	than	than	IN	IN	_	15	mwe	_	_
17	1	1	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	12	nmod	_	_
19	)	)	-RRB-	-RRB-	_	12	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	levels	level	NNS	NNS	_	12	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF(kappa)B	nf(kappa)b	NN	NN	_	21	nmod	_	_
24	(	(	-LRB-	-LRB-	_	23	punct	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	23	cc	_	_
27	Oct-1	oct-1	NN	NN	_	23	conj	_	_
28	)	)	-RRB-	-RRB-	_	23	punct	_	_
29	found	find	VBN	VBN	_	23	acl	_	_
30	in	in	IN	IN	_	35	case	_	_
31	nuclear	nuclear	JJ	JJ	_	35	amod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	whole	whole	JJ	JJ	_	34	amod	_	_
34	cell	cell	NN	NN	_	31	conj	_	_
35	extracts	extract	NNS	NNS	_	29	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	activated	activate	VBN	VBN	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	Strikingly	strikingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	immunosuppressive	immunosuppressive	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	TPCK	tpck	NN	NN	_	5	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	pretreated	pretreat	VBN	VBN	_	9	advcl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	15	15	CD	CD	_	17	nummod	_	_
17	min	min	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	5	5	CD	CD	_	20	compound	_	_
20	mM	mm	NN	NN	_	21	amod	_	_
21	NAC	nac	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	NAC	nac	NN	NN	_	4	nsubj	_	_
2	not	not	RB	RB	_	3	neg	_	_
3	only	only	RB	RB	_	4	cc:preconj	_	_
4	blocks	block	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TPCK	tpck	NN	NN	_	6	nmod	_	_
9	but	but	CC	CC	_	4	cc	_	_
10	enhances	enhance	VBZ	VBZ	_	4	conj	_	_
11	mitogenesis	mitogenesis	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	conj	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	&gt;	&gt;	JJR	JJR	_	17	dep	_	_
17	2.5-fold	2.5-fold	RB	RB	_	10	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	some	some	DT	DT	_	20	det	_	_
20	cases	case	NNS	NNS	_	17	nmod	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	upon	upon	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	10	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	unsuppressed	unsuppressed	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	notion	notion	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	NF(kappa)B	nf(kappa)b	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	I(kappa)B	i(kappa)b	NN	NN	_	7	conj	_	_
10	proteases	protease	NNS	NNS	_	11	nsubj	_	_
11	play	play	VBP	VBP	_	5	ccomp	_	_
12	obligate	obligate	JJ	JJ	_	13	amod	_	_
13	roles	role	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	mitogenesis	mitogenesis	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	11	punct	_	_
21	roles	role	NNS	NNS	_	11	dobj	_	_
22	that	that	WDT	WDT	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	enhanced	enhance	VBN	VBN	_	21	acl:relcl	_	_
25	significantly	significantly	RB	RB	_	24	advmod	_	_
26	by	by	IN	IN	_	27	case	_	_
27	NAC	nac	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	IL-12-induced	il-12-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	NK	nk	NN	NN	_	7	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	T	t	NN	NN	_	4	conj	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	occurs	occur	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	16	case	_	_
10	the	the	DT	DT	_	16	dep	_	_
11	absence	absence	NN	NN	_	16	dep	_	_
12	of	of	IN	IN	_	16	case	_	_
13	immediate-early	immediate-early	JJ	JJ	_	16	amod	_	_
14	activation	activation	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	responses	response	NNS	NNS	_	22	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	to	to	TO	TO	_	6	case	_	_
6	IL-2	il-2	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-12	il-12	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	2	punct	_	_
10	involving	involve	VBG	VBG	_	2	acl	_	_
11	proliferation	proliferation	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	differentiation	differentiation	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	2	punct	_	_
19	are	be	VBP	VBP	_	22	aux	_	_
20	only	only	RB	RB	_	21	advmod	_	_
21	partially	partially	RB	RB	_	22	advmod	_	_
22	overlapping	overlap	VBG	VBG	_	0	root	_	_
23	,	,	,	,	_	22	punct	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	depend	depend	VB	VB	_	22	conj	_	_
27	on	on	IN	IN	_	30	case	_	_
28	induced	induce	VBN	VBN	_	30	amod	_	_
29	differential	differential	JJ	JJ	_	30	amod	_	_
30	expression	expression	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	specific	specific	JJ	JJ	_	33	amod	_	_
33	sets	set	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	genes	gene	NNS	NNS	_	33	nmod	_	_
36	.	.	.	.	_	22	punct	_	_

1	Using	use	VBG	VBG	_	8	advcl	_	_
2	reverse-transcription	reverse-transcription	JJ	JJ	_	5	amod	_	_
3	PCR	pcr	NN	NN	_	5	compound	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	display	display	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	isolated	isolate	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	species	species	NNS	NNS	_	8	dobj	_	_
12	expressed	express	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	19	case	_	_
14	IL-2-	il-2-	NN	NN	_	19	amod	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	IL-12-stimulated	il-12-stimulated	JJ	JJ	_	14	conj	_	_
18	NK	nk	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	encoding	encode	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	egr-1	egr-1	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	6	punct	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	expressed	express	VBN	VBN	_	6	acl:relcl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	fast	fast	JJ	JJ	_	18	amod	_	_
18	kinetics	kinetics	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	T	t	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NK	nk	NN	NN	_	20	conj	_	_
23	cells	cell	NNS	NNS	_	15	nmod	_	_
24	upon	upon	IN	IN	_	31	case	_	_
25	IL-2	il-2	NN	NN	_	31	compound	_	_
26	,	,	,	,	_	25	punct	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	25	cc	_	_
29	IL-12	il-12	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	stimulation	stimulation	NN	NN	_	15	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	accumulation	accumulation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	mRNA-encoding	mrna-encoding	JJ	JJ	_	7	amod	_	_
7	members	member	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	AP-1	ap-1	NN	NN	_	13	compound	_	_
11	transcription	transcription	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	7	nmod	_	_
14	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	21	mark	_	_
16	c-fos	c-fos	NN	NN	_	21	nsubjpass	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	junB	junb	NN	NN	_	16	conj	_	_
19	are	be	VBP	VBP	_	21	auxpass	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	expressed	express	VBN	VBN	_	14	ccomp	_	_
22	upon	upon	IN	IN	_	23	case	_	_
23	stimulation	stimulation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	NK	nk	NN	NN	_	28	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	T	t	NN	NN	_	25	conj	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	with	with	IN	IN	_	30	case	_	_
30	IL-2	il-2	NN	NN	_	23	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	30	cc	_	_
34	IL-12	il-12	NN	NN	_	30	conj	_	_
35	,	,	,	,	_	21	punct	_	_
36	whereas	whereas	IN	IN	_	21	dep	_	_
37	expression	expression	NN	NN	_	44	nsubjpass	_	_
38	of	of	IN	IN	_	39	case	_	_
39	c-jun	c-jun	NN	NN	_	37	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	junD	jund	NN	NN	_	39	conj	_	_
42	is	be	VBZ	VBZ	_	44	auxpass	_	_
43	not	not	RB	RB	_	44	neg	_	_
44	modified	modify	VBN	VBN	_	21	parataxis	_	_
45	by	by	IN	IN	_	47	case	_	_
46	either	either	DT	DT	_	47	det	_	_
47	cytokine	cytokine	NN	NN	_	44	nmod	_	_
48	.	.	.	.	_	14	punct	_	_

1	Accordingly	accordingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	increased	increase	VBN	VBN	_	6	amod	_	_
4	AP-1	ap-1	NN	NN	_	6	compound	_	_
5	DNA-binding	dna-binding	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	12	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1-dependent	ap-1-dependent	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	exclusively	exclusively	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	IL-2-stimulated	il-2-stimulated	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Analysis	analysis	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	genes	gene	NNS	NNS	_	4	nmod	_	_
7	reported	report	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	regulate	regulate	VB	VB	_	7	xcomp	_	_
10	cytokine-induced	cytokine-induced	JJ	JJ	_	11	amod	_	_
11	proliferation	proliferation	NN	NN	_	9	dobj	_	_
12	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	IL-2	il-2	NN	NN	_	18	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IL-12	il-12	NN	NN	_	15	conj	_	_
18	induce	induce	VBP	VBP	_	12	ccomp	_	_
19	c-myc	c-myc	NN	NN	_	21	compound	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	accumulation	accumulation	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	NK	nk	NN	NN	_	26	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	T	t	NN	NN	_	23	conj	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	whereas	whereas	IN	IN	_	18	dep	_	_
29	only	only	RB	RB	_	30	advmod	_	_
30	IL-2	il-2	NN	NN	_	31	nsubj	_	_
31	induces	induce	VBZ	VBZ	_	18	parataxis	_	_
32	bcl-2	bcl-2	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	demonstration	demonstration	NN	NN	_	3	dobj	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	IL-12-mediated	il-12-mediated	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NK	nk	NN	NN	_	11	conj	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	involve	involve	VB	VB	_	6	ccomp	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	members	member	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	immediate-early	immediate-early	JJ	JJ	_	26	amod	_	_
24	activation	activation	NN	NN	_	26	compound	_	_
25	genes	gene	NNS	NNS	_	26	compound	_	_
26	family	family	NN	NN	_	20	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	egr-1	egr-1	NN	NN	_	26	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	c-fos	c-fos	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	junB	junb	NN	NN	_	28	conj	_	_
34	)	)	-RRB-	-RRB-	_	28	punct	_	_
35	,	,	,	,	_	18	punct	_	_
36	AP-1	ap-1	NN	NN	_	38	compound	_	_
37	transcriptional	transcriptional	JJ	JJ	_	38	amod	_	_
38	activity	activity	NN	NN	_	18	conj	_	_
39	,	,	,	,	_	18	punct	_	_
40	or	or	CC	CC	_	18	cc	_	_
41	bcl-2	bcl-2	NN	NN	_	42	compound	_	_
42	expression	expression	NN	NN	_	18	conj	_	_
43	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	indicates	indicate	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	differences	difference	NNS	NNS	_	13	nsubj	_	_
6	observed	observe	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	11	case	_	_
8	IL-2-	il-2-	NN	NN	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-12-stimulated	il-12-stimulated	JJ	JJ	_	8	conj	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	depend	depend	VB	VB	_	2	ccomp	_	_
14	,	,	,	,	_	13	punct	_	_
15	at	at	IN	IN	_	18	advmod	_	_
16	least	least	JJS	JJS	_	15	mwe	_	_
17	in	in	IN	IN	_	18	case	_	_
18	part	part	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	on	on	IN	IN	_	23	case	_	_
21	differential	differential	JJ	JJ	_	23	amod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	regulation	regulation	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	critical	critical	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	Sp1-	sp1-	NN	NN	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Ets-related	ets-related	JJ	JJ	_	5	conj	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	3	nmod	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	maintaining	maintain	VBG	VBG	_	3	acl	_	_
12	CTL-specific	ctl-specific	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	mouse	mouse	NN	NN	_	18	compound	_	_
17	perforin	perforin	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	designed	design	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	determine	determine	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	potential	potential	JJ	JJ	_	9	amod	_	_
9	cis-elements	cis-element	NNS	NNS	_	6	dobj	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	mouse	mouse	NN	NN	_	18	compound	_	_
17	perforin	perforin	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	DNase	dnase	NN	NN	_	4	compound	_	_
2	I	i	CD	CD	_	4	nummod	_	_
3	hypersensitive	hypersensitive	JJ	JJ	_	4	amod	_	_
4	site	site	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	DHS	dhs	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	mapping	mapping	NN	NN	_	9	nsubj	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	perforin	perforin	NN	NN	_	13	compound	_	_
13	locus	locus	NN	NN	_	14	nsubj	_	_
14	contained	contain	VBD	VBD	_	9	ccomp	_	_
15	six	six	CD	CD	_	16	nummod	_	_
16	DHS	dhs	NN	NN	_	14	dobj	_	_
17	within	within	IN	IN	_	19	case	_	_
18	7.0	7.0	CD	CD	_	19	nummod	_	_
19	kb	kb	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	5'	5'	JJ	JJ	_	23	amod	_	_
23	upstream	upstream	JJ	JJ	_	24	amod	_	_
24	sequence	sequence	NN	NN	_	19	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	-7.0	-7.0	CD	CD	_	27	nummod	_	_
27	kb	kb	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	and	and	CC	CC	_	14	cc	_	_
30	two	two	CD	CD	_	31	nummod	_	_
31	DHS	dhs	NN	NN	_	14	conj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	intron	intron	NN	NN	_	31	nmod	_	_
34	2	2	CD	CD	_	33	nummod	_	_
35	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	six	six	CD	CD	_	4	nummod	_	_
3	5'	5'	JJ	JJ	_	4	amod	_	_
4	upstream	upstream	JJ	JJ	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	one	one	CD	CD	_	7	nummod	_	_
7	intronic	intronic	JJ	JJ	_	4	conj	_	_
8	DHS	dhs	NN	NN	_	4	dep	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	only	only	RB	RB	_	14	advmod	_	_
13	perforin-expressing	perforin-expressing	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Chloramphenicol	chloramphenicol	NN	NN	_	2	compound	_	_
2	acetyltransferase	acetyltransferase	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CAT	cat	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	activities	activity	NNS	NNS	_	13	nsubjpass	_	_
7	directed	direct	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	5'	5'	JJ	JJ	_	10	amod	_	_
10	upstream	upstream	JJ	JJ	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	detected	detect	VBN	VBN	_	0	root	_	_
14	preferentially	preferentially	RB	RB	_	13	advmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	perforin-expressing	perforin-expressing	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	construct	construct	NN	NN	_	8	nsubj	_	_
3	termed	term	VBN	VBN	_	2	acl	_	_
4	PFP5a	pfp5a	NN	NN	_	3	xcomp	_	_
5	containing	contain	VBG	VBG	_	2	acl	_	_
6	-795	-795	CD	CD	_	7	nummod	_	_
7	bp	bp	NN	NN	_	5	dobj	_	_
8	exhibited	exhibit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	highest	highest	JJS	JJS	_	12	amod	_	_
11	CAT	cat	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	PFP9a20	pfp9a20	NN	NN	_	21	nsubj	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	only	only	RB	RB	_	19	advmod	_	_
18	-73	-73	CD	CD	_	19	nummod	_	_
19	bp	bp	NN	NN	_	16	dobj	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	produced	produce	VBD	VBD	_	8	conj	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	high	high	JJ	JJ	_	25	amod	_	_
24	CAT	cat	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	CTLL-R8	ctll-r8	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proximal	proximal	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	6	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	PFP9a20	pfp9a20	NN	NN	_	3	nmod	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	11	nummod	_	_
8	potential	potential	JJ	JJ	_	11	amod	_	_
9	Sp1	sp1	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	6	dobj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	GC	gc	NN	NN	_	14	compound	_	_
14	box	box	NN	NN	_	11	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	GT	gt	NN	NN	_	17	compound	_	_
17	box	box	NN	NN	_	14	conj	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	one	one	CD	CD	_	23	nummod	_	_
21	Ets	ets	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	11	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	EBS	ebs	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	6	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	each	each	DT	DT	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cis-elements	cis-element	NNS	NNS	_	7	nmod	_	_
11	bound	bind	VBD	VBD	_	5	ccomp	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	dobj	_	_
15	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	single-point	single-point	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	introduced	introduce	VBN	VBN	_	26	advcl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	each	each	DT	DT	_	9	det	_	_
8	GC	gc	NN	NN	_	9	compound	_	_
9	box	box	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	EBS	ebs	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	GT	gt	NN	NN	_	15	compound	_	_
15	box	box	NN	NN	_	9	conj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	PFP9a20	pfp9a20	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	26	punct	_	_
19	at	at	IN	IN	_	20	case	_	_
20	least	least	JJS	JJS	_	21	nmod:npmod	_	_
21	3-fold	3-fold	RB	RB	_	24	dep	_	_
22	less	less	JJR	JJR	_	21	dep	_	_
23	CAT	cat	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	observed	observe	VBN	VBN	_	0	root	_	_
27	in	in	IN	IN	_	29	case	_	_
28	CTLL-R8	ctll-r8	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	26	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	confirm	confirm	VB	VB	_	19	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	importance	importance	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	cis-acting	cis-acting	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	perforin	perforin	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	4	nmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	point	point	NN	NN	_	17	compound	_	_
17	mutation	mutation	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	introduced	introduce	VBN	VBN	_	0	root	_	_
20	again	again	RB	RB	_	19	advmod	_	_
21	to	to	TO	TO	_	25	case	_	_
22	each	each	DT	DT	_	25	det	_	_
23	proximal	proximal	JJ	JJ	_	25	amod	_	_
24	GC	gc	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	EBS	ebs	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	GT	gt	NN	NN	_	31	compound	_	_
31	box	box	NN	NN	_	25	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	PFP5a	pfp5a	NN	NN	_	25	nmod	_	_
34	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	point	point	NN	NN	_	3	compound	_	_
3	mutations	mutation	NNS	NNS	_	4	nsubj	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	2.5-	2.5-	CD	CD	_	10	nummod	_	_
8	to	to	TO	TO	_	7	dep	_	_
9	3-fold	3-fold	JJ	JJ	_	7	advmod	_	_
10	reduction	reduction	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CAT	cat	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	combination	combination	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	three	three	CD	CD	_	12	nummod	_	_
10	proximal	proximal	JJ	JJ	_	12	amod	_	_
11	cis-acting	cis-acting	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	6	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	constitute	constitute	VB	VB	_	3	ccomp	_	_
15	a	a	DT	DT	_	17	det	_	_
16	minimal	minimal	JJ	JJ	_	17	amod	_	_
17	region	region	NN	NN	_	14	dobj	_	_
18	responsible	responsible	JJ	JJ	_	17	amod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	CTL-specific	ctl-specific	JJ	JJ	_	21	amod	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	perforin	perforin	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	lymphocyte	lymphocyte	NN	NN	_	1	nmod	_	_
5	proliferation	proliferation	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	CD40	cd40	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	conj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	phosphorothioate	phosphorothioate	NN	NN	_	12	compound	_	_
12	oligonucleotides	oligonucleotide	NNS	NNS	_	1	nmod	_	_
13	complementary	complementary	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	hepatitis	hepatitis	NN	NN	_	18	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	virus	virus	NN	NN	_	18	compound	_	_
18	genome	genome	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	proliferation	proliferation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CD40	cd40	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cytotoxicity	cytotoxicity	NN	NN	_	5	conj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	of	of	IN	IN	_	22	case	_	_
20	antisense	antisense	JJ	JJ	_	22	amod	_	_
21	phosphorothioate	phosphorothioate	NN	NN	_	22	compound	_	_
22	oligodeoxynucleotides	oligodeoxynucleotide	NNS	NNS	_	15	nmod	_	_
23	complementary	complementary	JJ	JJ	_	22	amod	_	_
24	to	to	TO	TO	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	SP	sp	NN	NN	_	28	compound	_	_
27	II	ii	CD	CD	_	28	nummod	_	_
28	promoter	promoter	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	HBV	hbv	NN	NN	_	31	compound	_	_
31	mRNA	mrna	NN	NN	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	sequence	sequence	NN	NN	_	34	compound	_	_
34	I	i	NN	NN	_	28	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	and	and	CC	CC	_	28	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	X	x	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	28	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	sequence	sequence	NN	NN	_	39	appos	_	_
42	II	ii	CD	CD	_	41	nummod	_	_
43	)	)	-RRB-	-RRB-	_	41	punct	_	_
44	in	in	IN	IN	_	45	case	_	_
45	patients	patient	NNS	NNS	_	28	nmod	_	_
46	with	with	IN	IN	_	49	case	_	_
47	chronic	chronic	JJ	JJ	_	49	amod	_	_
48	hepatitis	hepatitis	NN	NN	_	49	compound	_	_
49	B	b	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	oligo	oligo	JJ	JJ	_	4	amod	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	I	i	NN	NN	_	5	nsubj	_	_
5	stimulated	stimulate	VBD	VBD	_	0	root	_	_
6	proliferation	proliferation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	T	t	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	,	,	,	,	_	9	punct	_	_
12	to	to	TO	TO	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	lesser	lesser	JJR	JJR	_	15	amod	_	_
15	extent	extent	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	B	b	NN	NN	_	9	conj	_	_
18	cells	cell	NNS	NNS	_	9	dep	_	_
19	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	percentage	percentage	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	cells	cell	NNS	NNS	_	2	nmod	_	_
5	expressing	express	VBG	VBG	_	4	acl	_	_
6	CD40	cd40	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	T	t	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	B	b	NN	NN	_	8	conj	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	co-cultures	co-culture	NNS	NNS	_	8	dep	_	_
13	increased	increase	VBD	VBD	_	0	root	_	_
14	from	from	IN	IN	_	16	case	_	_
15	4.2	4.2	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	13.8	13.8	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	13	nmod	_	_
20	after	after	IN	IN	_	22	case	_	_
21	oligo	oligo	JJ	JJ	_	22	amod	_	_
22	stimulation	stimulation	NN	NN	_	13	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	patients	patient	NNS	NNS	_	22	nmod	_	_
25	,	,	,	,	_	13	punct	_	_
26	while	while	IN	IN	_	28	mark	_	_
27	it	it	PRP	PRP	_	28	nsubj	_	_
28	increased	increase	VBD	VBD	_	13	advcl	_	_
29	form	form	NN	NN	_	28	dobj	_	_
30	4.7	4.7	CD	CD	_	31	nummod	_	_
31	%	%	NN	NN	_	29	dep	_	_
32	to	to	TO	TO	_	34	case	_	_
33	48.6	48.6	CD	CD	_	34	nummod	_	_
34	%	%	NN	NN	_	28	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	healthy	healthy	JJ	JJ	_	37	amod	_	_
37	controls	control	NNS	NNS	_	28	nmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	sense	sense	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	13	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	sequence	sequence	NN	NN	_	3	appos	_	_
6	III	iii	CD	CD	_	5	nummod	_	_
7	)	)	-RRB-	-RRB-	_	5	punct	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	X	x	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	enhanced	enhance	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	CD40	cd40	NN	NN	_	18	compound	_	_
18	antigen	antigen	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	15	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	hepatitis	hepatitis	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proportion	proportion	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CD40	cd40	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	26	26	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	2	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	resting	rest	VBG	VBG	_	14	amod	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	preparation	preparation	NN	NN	_	2	nmod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	hepatitis	hepatitis	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	14	nmod	_	_
19	decreased	decrease	VBD	VBD	_	0	root	_	_
20	to	to	TO	TO	_	21	case	_	_
21	zero	zero	CD	CD	_	19	nmod	_	_
22	after	after	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	5-day	5-day	JJ	JJ	_	25	amod	_	_
25	culture	culture	NN	NN	_	19	nmod	_	_
26	with	with	IN	IN	_	28	case	_	_
27	sequence	sequence	NN	NN	_	28	compound	_	_
28	I	i	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	19	punct	_	_
30	but	but	CC	CC	_	19	cc	_	_
31	IgG	igg	NN	NN	_	32	compound	_	_
32	levels	level	NNS	NNS	_	37	nsubj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	culture	culture	NN	NN	_	36	compound	_	_
36	supernatant	supernatant	NN	NN	_	32	nmod	_	_
37	increased	increase	VBD	VBD	_	19	conj	_	_
38	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytotoxic	cytotoxic	JJ	JJ	_	3	amod	_	_
3	properties	property	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	influenced	influence	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	oligos	oligo	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	antisense	antisense	JJ	JJ	_	6	amod	_	_
6	oligos	oligo	NNS	NNS	_	14	nsubj	_	_
7	against	against	IN	IN	_	10	case	_	_
8	hepatitis	hepatitis	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	virus	virus	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HBV	hbv	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	have	have	VBP	VBP	_	3	ccomp	_	_
15	mitogenic	mitogenic	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	14	dobj	_	_
17	on	on	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	proliferation	proliferation	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	non-specific	non-specific	JJ	JJ	_	26	amod	_	_
26	manner	manner	NN	NN	_	14	nmod	_	_
27	and	and	CC	CC	_	14	cc	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	activate	activate	VB	VB	_	14	conj	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	29	dobj	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	express	express	VB	VB	_	29	xcomp	_	_
34	CD40	cd40	NN	NN	_	35	compound	_	_
35	antigen	antigen	NN	NN	_	33	dobj	_	_
36	.	.	.	.	_	3	punct	_	_

1	Soluble	soluble	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	7	nsubj	_	_
3	secreted	secrete	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	T-lymphocytes	t-lymphocyte	NNS	NNS	_	3	nmod	_	_
7	modulate	modulate	VBP	VBP	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	immunosuppressive	immunosuppressive	JJ	JJ	_	14	amod	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	TGF-beta	tgf-beta	NN	NN	_	9	nmod	_	_
15	2	2	CD	CD	_	14	nummod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	glial	glial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Coordination	coordination	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	injury	injury	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	disease	disease	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	brain	brain	NN	NN	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	postulated	postulate	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	involve	involve	VB	VB	_	14	xcomp	_	_
17	bi-directional	bi-directional	JJ	JJ	_	18	amod	_	_
18	discourse	discourse	NN	NN	_	16	dobj	_	_
19	between	between	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	immune	immune	JJ	JJ	_	22	amod	_	_
22	system	system	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	27	det	_	_
25	central	central	JJ	JJ	_	27	amod	_	_
26	nervous	nervous	JJ	JJ	_	27	amod	_	_
27	system	system	NN	NN	_	22	conj	_	_
28	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cross	cross	JJ	JJ	_	3	amod	_	_
3	communication	communication	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	soluble	soluble	JJ	JJ	_	6	amod	_	_
6	mediators	mediator	NNS	NNS	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	including	include	VBG	VBG	_	11	case	_	_
9	various	various	JJ	JJ	_	11	amod	_	_
10	growth	growth	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	cytokines	cytokine	NNS	NNS	_	6	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	neuropeptides	neuropeptide	NNS	NNS	_	6	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	supernatant	supernatant	NN	NN	_	14	nsubj	_	_
10	from	from	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	able	able	JJ	JJ	_	6	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	transcription	transcription	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	potent	potent	JJ	JJ	_	22	amod	_	_
22	cytokine	cytokine	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	TGF-beta	tgf-beta	NN	NN	_	22	appos	_	_
25	2	2	CD	CD	_	24	nummod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	glial	glial	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	activating	activate	VBG	VBG	_	3	amod	_	_
3	stimulus	stimulus	NN	NN	_	4	nsubj	_	_
4	invokes	invoke	VBZ	VBZ	_	0	root	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
7	distinct	distinct	JJ	JJ	_	6	amod	_	_
8	from	from	IN	IN	_	13	case	_	_
9	known	known	JJ	JJ	_	13	amod	_	_
10	kinase	kinase	NN	NN	_	13	compound	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	protease	protease	NN	NN	_	10	conj	_	_
13	pathways	pathway	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	TGF-beta	tgf-beta	NN	NN	_	5	compound	_	_
4	2	2	CD	CD	_	5	nummod	_	_
5	transcription	transcription	NN	NN	_	1	nmod	_	_
6	correlates	correlate	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	loss	loss	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	20	case	_	_
14	an	a	DT	DT	_	20	det	_	_
15	80	80	CD	CD	_	20	nummod	_	_
16	kDA	kda	NN	NN	_	20	compound	_	_
17	glial	glial	JJ	JJ	_	20	amod	_	_
18	labile	labile	NN	NN	_	20	compound	_	_
19	repressor	repressor	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	GLRP	glrp	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	20	punct	_	_
24	to	to	TO	TO	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	responsive	responsive	JJ	JJ	_	27	amod	_	_
27	region	region	NN	NN	_	12	nmod	_	_
28	within	within	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	TFG-beta	tfg-beta	NN	NN	_	32	compound	_	_
31	2	2	CD	CD	_	32	nummod	_	_
32	promoter	promoter	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	GLRP	glrp	NN	NN	_	3	nsubj	_	_
3	shares	share	VBZ	VBZ	_	14	advcl	_	_
4	some	some	DT	DT	_	5	det	_	_
5	characteristics	characteristic	NNS	NNS	_	3	dobj	_	_
6	with	with	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	inducible	inducible	JJ	JJ	_	11	amod	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	AP-1	ap-1	NN	NN	_	3	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	it	it	PRP	PRP	_	14	nsubj	_	_
14	appears	appear	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	distinct	distinct	JJ	JJ	_	14	xcomp	_	_
18	from	from	IN	IN	_	22	case	_	_
19	known	known	JJ	JJ	_	22	amod	_	_
20	AP-1	ap-1	NN	NN	_	22	compound	_	_
21	family	family	NN	NN	_	22	compound	_	_
22	members	member	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	16	nsubj	_	_
3	along	along	IN	IN	_	6	case	_	_
4	with	with	IN	IN	_	6	case	_	_
5	previous	previous	JJ	JJ	_	6	amod	_	_
6	observations	observation	NNS	NNS	_	2	nmod	_	_
7	demonstrating	demonstrate	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	potent	potent	JJ	JJ	_	11	amod	_	_
10	immunosuppressive	immunosuppressive	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	TGF-beta	tgf-beta	NN	NN	_	11	nmod	_	_
14	2	2	CD	CD	_	13	nummod	_	_
15	,	,	,	,	_	16	punct	_	_
16	support	support	VBP	VBP	_	0	root	_	_
17	a	a	DT	DT	_	18	det	_	_
18	model	model	NN	NN	_	16	dobj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	feedback	feedback	NN	NN	_	22	compound	_	_
22	mechanism	mechanism	NN	NN	_	18	nmod	_	_
23	between	between	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	activated	activate	VBN	VBN	_	26	amod	_	_
26	T-lymphocytes	t-lymphocyte	NNS	NNS	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	astrocytes	astrocyte	NNS	NNS	_	26	conj	_	_
29	via	via	IN	IN	_	30	case	_	_
30	TGF-beta	tgf-beta	NN	NN	_	22	nmod	_	_
31	2	2	CD	CD	_	30	nummod	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	regulate	regulate	VB	VB	_	22	acl	_	_
34	the	the	DT	DT	_	36	det	_	_
35	immune	immune	JJ	JJ	_	36	amod	_	_
36	response	response	NN	NN	_	33	dobj	_	_
37	.	.	.	.	_	16	punct	_	_

1	Dual	dual	JJ	JJ	_	2	amod	_	_
2	action	action	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	retinoic	retinoic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	embryonic/fetal	embryonic/fetal	JJ	JJ	_	9	amod	_	_
9	hematopoiesis	hematopoiesis	NN	NN	_	2	nmod	_	_
10	:	:	:	:	_	2	punct	_	_
11	blockade	blockade	NN	NN	_	2	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	primitive	primitive	JJ	JJ	_	15	amod	_	_
14	progenitor	progenitor	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	shift	shift	NN	NN	_	11	conj	_	_
18	from	from	IN	IN	_	19	case	_	_
19	multipotent/erythroid/monocytic	multipotent/erythroid/monocytic	JJ	JJ	_	17	nmod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	granulocytic	granulocytic	JJ	JJ	_	17	nmod	_	_
22	differentiation	differentiation	NN	NN	_	23	compound	_	_
23	program	program	NN	NN	_	17	dep	_	_
24	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	preliminary	preliminary	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	analyzed	analyze	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	15	det	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
10	growth	growth	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	HGF	hgf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	requirement	requirement	NN	NN	_	7	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	19	amod	_	_
18	progenitor	progenitor	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	HPCs	hpc	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	purified	purify	VBN	VBN	_	19	dep	_	_
24	from	from	IN	IN	_	26	case	_	_
25	embryonic-fetal	embryonic-fetal	JJ	JJ	_	26	amod	_	_
26	liver	liver	NN	NN	_	23	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	FL	fl	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	grown	grow	VBN	VBN	_	23	conj	_	_
32	in	in	IN	IN	_	40	case	_	_
33	fetal	fetal	JJ	JJ	_	35	amod	_	_
34	calf	calf	NN	NN	_	35	nmod:npmod	_	_
35	serum-supplemented	serum-supplemented	JJ	JJ	_	40	amod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	FCS+	fcs+	NN	NN	_	35	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	clonogenic	clonogenic	JJ	JJ	_	40	amod	_	_
40	culture	culture	NN	NN	_	31	nmod	_	_
41	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	key	key	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	25	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	erythropoietin	erythropoietin	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Epo	epo	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	for	for	IN	IN	_	11	case	_	_
10	colony	colony	NN	NN	_	11	compound	_	_
11	formation	formation	NN	NN	_	3	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	burst-forming	burst-forming	JJ	JJ	_	18	amod	_	_
18	units-erythroid	units-erythroid	JJ	JJ	_	15	dep	_	_
19	-LSB-	-lsb-	-LRB-	-LRB-	_	20	punct	_	_
20	BFU-E	bfu-e	NN	NN	_	18	appos	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	20	punct	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	confirmed	confirm	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	Furthermore	furthermore	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	in	in	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	dep	_	_
5	absence	absence	NN	NN	_	8	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	exogenous	exogenous	JJ	JJ	_	8	amod	_	_
8	HGFs	hgf	NNS	NNS	_	21	nmod	_	_
9	,	,	,	,	_	21	punct	_	_
10	FL	fl	NN	NN	_	12	compound	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	progenitors	progenitor	NNS	NNS	_	21	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	colony-forming	colony-forming	JJ	JJ	_	16	amod	_	_
15	unit	unit	NN	NN	_	16	compound	_	_
16	monocyte	monocyte	NN	NN	_	12	dep	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	CFU-M	cfu-m	NN	NN	_	16	appos	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	generate	generate	VBP	VBP	_	0	root	_	_
22	large	large	JJ	JJ	_	23	amod	_	_
23	colonies	colony	NNS	NNS	_	21	dobj	_	_
24	exclusively	exclusively	RB	RB	_	25	advmod	_	_
25	composed	compose	VBN	VBN	_	23	acl	_	_
26	of	of	IN	IN	_	27	case	_	_
27	monocytes-macrophages	monocytes-macrophage	NNS	NNS	_	25	nmod	_	_
28	;	;	:	:	_	21	punct	_	_
29	these	these	DT	DT	_	30	det	_	_
30	colonies	colony	NNS	NNS	_	32	nsubj	_	_
31	are	be	VBP	VBP	_	32	cop	_	_
32	absent	absent	JJ	JJ	_	21	parataxis	_	_
33	in	in	IN	IN	_	36	case	_	_
34	FCS-	fcs-	NN	NN	_	36	compound	_	_
35	clonogenic	clonogenic	JJ	JJ	_	36	amod	_	_
36	culture	culture	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	21	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	investigated	investigate	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	all-trans	all-trans	JJ	JJ	_	13	amod	_	_
12	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
13	acid	acid	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	ATRA	atra	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
19	isomer	isomer	NN	NN	_	21	compound	_	_
20	9-cis	9-cis	JJ	JJ	_	21	amod	_	_
21	RA	ra	NN	NN	_	13	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	FL	fl	NN	NN	_	24	compound	_	_
24	hematopoiesis	hematopoiesis	NN	NN	_	9	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	compounds	compound	NNS	NNS	_	3	nsubj	_	_
3	modulate	modulate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	growth	growth	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	purified	purify	VBN	VBN	_	9	amod	_	_
8	FL	fl	NN	NN	_	9	compound	_	_
9	HPCs	hpc	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	show	show	VBP	VBP	_	9	acl:relcl	_	_
13	a	a	DT	DT	_	15	det	_	_
14	dose-dependent	dose-dependent	JJ	JJ	_	15	amod	_	_
15	shift	shift	NN	NN	_	12	dobj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	mixed/erythroid/monocytic	mixed/erythroid/monocytic	JJ	JJ	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	granulocytic	granulocytic	JJ	JJ	_	15	nmod	_	_
20	colony	colony	NN	NN	_	21	compound	_	_
21	formation	formation	NN	NN	_	15	dep	_	_
22	.	.	.	.	_	3	punct	_	_

1	Studies	study	NNS	NNS	_	10	nsubj	_	_
2	on	on	IN	IN	_	8	case	_	_
3	unicellular	unicellular	JJ	JJ	_	8	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	paired	paired	JJ	JJ	_	3	conj	_	_
6	daughter	daughter	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	culture	culture	NN	NN	_	1	nmod	_	_
9	unequivocally	unequivocally	RB	RB	_	10	advmod	_	_
10	indicate	indicate	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	15	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	shift	shift	NN	NN	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	10	ccomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	modulation	modulation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	HPC	hpc	NN	NN	_	22	compound	_	_
21	differentiation	differentiation	NN	NN	_	22	compound	_	_
22	program	program	NN	NN	_	17	nmod	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	granulopoietic	granulopoietic	JJ	JJ	_	26	amod	_	_
26	pathway	pathway	NN	NN	_	17	nmod	_	_
27	(	(	-LRB-	-LRB-	_	17	punct	_	_
28	rather	rather	RB	RB	_	17	cc	_	_
29	than	than	IN	IN	_	28	mwe	_	_
30	RA-induced	ra-induced	JJ	JJ	_	31	amod	_	_
31	down-modulation	down-modulation	NN	NN	_	17	conj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	multipotent/erythroid/monocytic	multipotent/erythroid/monocytic	JJ	JJ	_	35	amod	_	_
34	HPC	hpc	NN	NN	_	35	compound	_	_
35	growth	growth	NN	NN	_	31	nmod	_	_
36	coupled	couple	VBN	VBN	_	31	acl	_	_
37	with	with	IN	IN	_	38	case	_	_
38	recruitment	recruitment	NN	NN	_	36	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	granulocytic	granulocytic	JJ	JJ	_	41	amod	_	_
41	HPCs	hpc	NNS	NNS	_	38	nmod	_	_
42	)	)	-RRB-	-RRB-	_	17	punct	_	_
43	.	.	.	.	_	10	punct	_	_

1	ATRA	atra	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	9-cis	9-cis	JJ	JJ	_	4	amod	_	_
4	RA	ra	NN	NN	_	1	conj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	exert	exert	VBP	VBP	_	0	root	_	_
7	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	proliferation	proliferation	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	primitive	primitive	JJ	JJ	_	14	amod	_	_
14	HPCs	hpc	NNS	NNS	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	high-proliferative	high-proliferative	JJ	JJ	_	17	amod	_	_
17	potential	potential	JJ	JJ	_	19	amod	_	_
18	colony-forming	colony-forming	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	14	dep	_	_
20	-LSB-	-lsb-	-LRB-	-LRB-	_	21	punct	_	_
21	HPP-CFCs	hpp-cfc	NNS	NNS	_	19	appos	_	_
22	-RSB-	-rsb-	-RRB-	-RRB-	_	21	punct	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	putative	putative	JJ	JJ	_	28	amod	_	_
26	hematopoietic	hematopoietic	JJ	JJ	_	28	amod	_	_
27	stem	stem	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	14	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HSCs	hsc	NNS	NNS	_	28	dep	_	_
31	;	;	:	:	_	30	punct	_	_
32	assayed	assay	VBN	VBN	_	30	acl	_	_
33	in	in	IN	IN	_	36	case	_	_
34	Dexter-type	dexter-type	JJ	JJ	_	36	amod	_	_
35	long-term	long-term	JJ	JJ	_	36	amod	_	_
36	culture	culture	NN	NN	_	32	nmod	_	_
37	)	)	-RRB-	-RRB-	_	30	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	concentrations	concentration	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	either	either	DT	DT	_	5	det	_	_
5	compound	compound	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	1	1	LS	LS	_	10	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	drastically	drastically	RB	RB	_	10	advmod	_	_
10	reduced	reduce	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	number	number	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	primary	primary	JJ	JJ	_	16	amod	_	_
15	HPP-CFC	hpp-cfc	NN	NN	_	16	compound	_	_
16	colonies	colony	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	totally	totally	RB	RB	_	19	advmod	_	_
19	abolished	abolish	VBD	VBD	_	10	conj	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	recloning	reclon	VBG	VBG	_	22	amod	_	_
22	capacity	capacity	NN	NN	_	19	dobj	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	2	2	LS	LS	_	27	dep	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	inhibited	inhibit	VBD	VBD	_	10	conj	_	_
28	HSC	hsc	NN	NN	_	29	compound	_	_
29	proliferation	proliferation	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	10	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	crucial	crucial	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	these	these	DT	DT	_	6	det	_	_
6	results	result	NNS	NNS	_	7	nsubj	_	_
7	mirror	mirror	VBP	VBP	_	3	ccomp	_	_
8	recent	recent	JJ	JJ	_	9	amod	_	_
9	observations	observation	NNS	NNS	_	7	dobj	_	_
10	indicating	indicate	VBG	VBG	_	9	acl	_	_
11	that	that	IN	IN	_	26	mark	_	_
12	murine	murine	JJ	JJ	_	14	amod	_	_
13	adult	adult	JJ	JJ	_	14	amod	_	_
14	HPCs	hpc	NNS	NNS	_	26	nsubjpass	_	_
15	transduced	transduce	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	24	case	_	_
17	dominant	dominant	JJ	JJ	_	24	amod	_	_
18	negative	negative	JJ	JJ	_	24	amod	_	_
19	ATRA	atra	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	RAR	rar	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	immortalized	immortalize	VBN	VBN	_	10	ccomp	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	show	show	VBP	VBP	_	26	conj	_	_
29	a	a	DT	DT	_	31	det	_	_
30	selective	selective	JJ	JJ	_	31	amod	_	_
31	blockade	blockade	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	granulocytic	granulocytic	JJ	JJ	_	34	amod	_	_
34	differentiation	differentiation	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	ATRA/9-cis	atra/9-cis	NN	NN	_	8	compound	_	_
8	RA	ra	NN	NN	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	play	play	VB	VB	_	5	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	key	key	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	FL	fl	NN	NN	_	16	compound	_	_
16	hematopoiesis	hematopoiesis	NN	NN	_	10	nmod	_	_
17	via	via	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	dual	dual	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	10	nmod	_	_
21	hypothetically	hypothetically	RB	RB	_	22	advmod	_	_
22	mediated	mediate	VBN	VBN	_	20	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	interaction	interaction	NN	NN	_	22	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	RAR/RXR	rar/rxr	NN	NN	_	28	compound	_	_
28	heterodimer	heterodimer	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	32	punct	_	_
30	ie	ie	FW	FW	_	32	advmod	_	_
31	,	,	,	,	_	32	punct	_	_
32	inhibition	inhibition	NN	NN	_	20	dep	_	_
33	of	of	IN	IN	_	38	case	_	_
34	HSC	hsc	NN	NN	_	38	compound	_	_
35	/	/	:	:	_	34	punct	_	_
36	primitive	primitive	JJ	JJ	_	37	amod	_	_
37	HPC	hpc	NN	NN	_	34	dep	_	_
38	proliferation	proliferation	NN	NN	_	32	nmod	_	_
39	and	and	CC	CC	_	32	cc	_	_
40	induction	induction	NN	NN	_	32	conj	_	_
41	of	of	IN	IN	_	51	case	_	_
42	CFU-GEMM/BFU-E/CFU-M	cfu-gemm/bfu-e/cfu-m	NN	NN	_	43	amod	_	_
43	shift	shift	NN	NN	_	51	compound	_	_
44	from	from	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	multipotent/erythroid/monocytic	multipotent/erythroid/monocytic	JJ	JJ	_	43	nmod	_	_
47	to	to	TO	TO	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	granulocytic-neutrophilic	granulocytic-neutrophilic	JJ	JJ	_	43	nmod	_	_
50	differentiation	differentiation	NN	NN	_	43	dep	_	_
51	program	program	NN	NN	_	40	nmod	_	_
52	.	.	.	.	_	5	punct	_	_

1	Vitamin	vitamin	NN	NN	_	2	compound	_	_
2	D3-	d3-	NN	NN	_	7	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	retinoic	retinoic	JJ	JJ	_	5	amod	_	_
5	acid-induced	acid-induced	JJ	JJ	_	2	conj	_	_
6	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	0	root	_	_
8	:	:	:	:	_	7	punct	_	_
9	interactions	interaction	NNS	NNS	_	7	dep	_	_
10	between	between	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
13	vitamin	vitamin	NN	NN	_	15	compound	_	_
14	D3	d3	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	retinoic	retinoic	JJ	JJ	_	19	amod	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	retinoid	retinoid	NN	NN	_	24	compound	_	_
23	X	x	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	15	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	U-937	u-937	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	15	nmod	_	_
28	.	.	.	.	_	9	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	14	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	1,25	1,25	CD	CD	_	8	nummod	_	_
8	alpha-dihydroxycholecalciferol	alpha-dihydroxycholecalciferol	NN	NN	_	2	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VitD3	vitd3	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	potent	potent	JJ	JJ	_	14	amod	_	_
14	regulators	regulator	NNS	NNS	_	0	root	_	_
15	of	of	IN	IN	_	17	case	_	_
16	hematopoletic	hematopoletic	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Yet	yet	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	as	as	IN	IN	_	15	mark	_	_
7	to	to	TO	TO	_	6	mwe	_	_
8	how	how	WRB	WRB	_	15	advmod	_	_
9	the	the	DT	DT	_	14	det	_	_
10	RA	ra	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	VitD3	vitd3	NN	NN	_	10	conj	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	network	network	NN	NN	_	15	nsubj	_	_
15	operates	operate	VBZ	VBZ	_	5	advcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	whether	whether	IN	IN	_	25	mark	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	interactions	interaction	NNS	NNS	_	25	nsubj	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	explain	explain	VB	VB	_	15	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	interplay	interplay	NN	NN	_	25	dobj	_	_
28	between	between	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	RA-	ra-	NN	NN	_	33	amod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	VitD3-signaling	vitd3-signaling	JJ	JJ	_	30	conj	_	_
33	pathways	pathway	NNS	NNS	_	27	nmod	_	_
34	during	during	IN	IN	_	35	case	_	_
35	differentiation	differentiation	NN	NN	_	27	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	analyzed	analyze	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	6	conj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	endogenous	endogenous	JJ	JJ	_	20	amod	_	_
17	RA	ra	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	VitD3	vitd3	NN	NN	_	17	conj	_	_
20	receptors	receptor	NNS	NNS	_	6	nmod	_	_
21	-LSB-	-lsb-	-LRB-	-LRB-	_	24	punct	_	_
22	retinoic	retinoic	JJ	JJ	_	24	amod	_	_
23	acid	acid	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	20	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	RARs	rar	NNS	NNS	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	24	punct	_	_
29	retinoid	retinoid	NN	NN	_	31	compound	_	_
30	X	x	NN	NN	_	31	compound	_	_
31	receptors	receptor	NNS	NNS	_	24	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	RXRs	rxr	NNS	NNS	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	24	punct	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	VitD3	vitd3	NN	NN	_	38	compound	_	_
38	receptor	receptor	NN	NN	_	24	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	VDR	vdr	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	-RSB-	-rsb-	-RRB-	-RRB-	_	24	punct	_	_
43	in	in	IN	IN	_	47	case	_	_
44	the	the	DT	DT	_	47	det	_	_
45	U-937	u-937	NN	NN	_	47	compound	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	line	line	NN	NN	_	6	nmod	_	_
48	,	,	,	,	_	47	punct	_	_
49	in	in	IN	IN	_	50	case	_	_
50	which	which	WDT	WDT	_	54	nmod	_	_
51	RA	ra	NN	NN	_	54	nsubj	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	VitD3	vitd3	NN	NN	_	51	conj	_	_
54	induce	induce	VBP	VBP	_	47	acl:relcl	_	_
55	distinct	distinct	JJ	JJ	_	58	amod	_	_
56	monocytic	monocytic	JJ	JJ	_	58	amod	_	_
57	differentiation	differentiation	NN	NN	_	58	compound	_	_
58	pathways	pathway	NNS	NNS	_	54	dobj	_	_
59	.	.	.	.	_	4	punct	_	_

1	VitD3	vitd3	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	formation	formation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	VDR/RXR	vdr/rxr	NN	NN	_	10	compound	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	6	nmod	_	_
11	on	on	IN	IN	_	15	case	_	_
12	both	both	CC	CC	_	15	cc:preconj	_	_
13	VitD3	vitd3	NN	NN	_	15	compound	_	_
14	response	response	NN	NN	_	15	compound	_	_
15	elements	element	NNS	NNS	_	6	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	RA	ra	NN	NN	_	19	compound	_	_
18	response	response	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	15	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	RAREs	rare	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	VitD3	vitd3	NN	NN	_	12	nmod:npmod	_	_
11	response	response	NN	NN	_	12	nmod:npmod	_	_
12	element-driven	element-driven	JJ	JJ	_	14	amod	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	construct	construct	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	complexes	complex	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	RAREs	rare	NNS	NNS	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	undifferentiated	undifferentiated	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	4	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	RA	ra	NN	NN	_	1	nmod	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	increased	increase	VBN	VBN	_	10	amod	_	_
7	RAR	rar	NN	NN	_	8	dep	_	_
8	beta/RXR	beta/rxr	NN	NN	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	binding	binding	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	RARE-dependent	rare-dependent	JJ	JJ	_	14	amod	_	_
14	transcription	transcription	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	increased	increase	VBN	VBN	_	18	amod	_	_
18	expression	expression	NN	NN	_	10	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	RAR-beta	rar-beta	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Concomitant	concomitant	JJ	JJ	_	2	amod	_	_
2	stimulation	stimulation	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	VitD3	vitd3	NN	NN	_	2	nmod	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	RA-stimulated	ra-stimulated	JJ	JJ	_	8	amod	_	_
8	formation	formation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	RAR	rar	NN	NN	_	11	dep	_	_
11	beta/RXR	beta/rxr	NN	NN	_	12	amod	_	_
12	heterodimers	heterodimer	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	favoring	favor	VBG	VBG	_	5	advcl	_	_
15	VDR/RXR	vdr/rxr	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	14	dobj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	RARE	rare	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Also	also	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	VitD3	vitd3	NN	NN	_	4	nsubj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CD23	cd23	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CD49f	cd49f	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	characteristic	characteristic	JJ	JJ	_	13	amod	_	_
13	markers	marker	NNS	NNS	_	8	appos	_	_
14	of	of	IN	IN	_	18	case	_	_
15	retinoid-induced	retinoid-induced	JJ	JJ	_	18	amod	_	_
16	U-937	u-937	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	16	dep	_	_
2	contrast	contrast	NN	NN	_	16	nsubjpass	_	_
3	,	,	,	,	_	16	punct	_	_
4	neither	neither	CC	CC	_	9	cc:preconj	_	_
5	the	the	DT	DT	_	9	det	_	_
6	RA-stimulated	ra-stimulated	JJ	JJ	_	9	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	RARE-mediated	rare-mediated	JJ	JJ	_	6	dep	_	_
9	transcription	transcription	NN	NN	_	16	nsubjpass	_	_
10	nor	nor	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	14	det	_	_
12	induced	induce	VBN	VBN	_	14	amod	_	_
13	RAR-beta	rar-beta	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	9	conj	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	suppressed	suppress	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	VitD3	vitd3	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	suggesting	suggest	VBG	VBG	_	16	xcomp	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	VitD3	vitd3	NN	NN	_	24	nsubj	_	_
23	selectively	selectively	RB	RB	_	24	advmod	_	_
24	inhibited	inhibit	VBD	VBD	_	20	ccomp	_	_
25	the	the	DT	DT	_	28	det	_	_
26	retinoid-induced	retinoid-induced	JJ	JJ	_	28	amod	_	_
27	differentiation	differentiation	NN	NN	_	28	compound	_	_
28	program	program	NN	NN	_	24	dobj	_	_
29	but	but	CC	CC	_	30	cc	_	_
30	not	not	RB	RB	_	28	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	RARE-mediated	rare-mediated	JJ	JJ	_	33	amod	_	_
33	signal	signal	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	complex	complex	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	VitD3	vitd3	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	modifying	modify	VBG	VBG	_	6	acl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	retinoid	retinoid	NN	NN	_	14	compound	_	_
13	differentiation	differentiation	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	10	dobj	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	have	have	VB	VB	_	3	conj	_	_
18	implications	implication	NNS	NNS	_	17	dobj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	differentiation-inducing	differentiation-inducing	JJ	JJ	_	21	amod	_	_
21	therapy	therapy	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	hematopoietic	hematopoietic	JJ	JJ	_	24	amod	_	_
24	tumors	tumor	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	interferon-gamma	interferon-gamma	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	.	.	.	.	_	1	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	17	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	known	know	VBN	VBN	_	1	acl	_	_
8	as	as	IN	IN	_	11	case	_	_
9	type	type	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	interferon	interferon	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	an	a	DT	DT	_	17	det	_	_
15	important	important	JJ	JJ	_	17	amod	_	_
16	immunoregulatory	immunoregulatory	JJ	JJ	_	17	amod	_	_
17	gene	gene	NN	NN	_	0	root	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	has	have	VBZ	VBZ	_	17	acl:relcl	_	_
20	multiple	multiple	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	19	dobj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	development	development	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	maturation	maturation	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	function	function	NN	NN	_	24	conj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	system	system	NN	NN	_	24	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	6	nsubjpass	_	_
2	mRNA	mrna	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	protein	protein	NN	NN	_	2	conj	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	predominantly	predominantly	RB	RB	_	10	advmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	large	large	JJ	JJ	_	14	amod	_	_
13	granular	granular	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IFN-gamma	ifn-gamma	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	induced/inhibited	induced/inhibited	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	these	these	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	types	type	NNS	NNS	_	5	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	wide	wide	JJ	JJ	_	13	amod	_	_
13	variety	variety	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	extracellular	extracellular	JJ	JJ	_	16	amod	_	_
16	signals	signal	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	thus	thus	RB	RB	_	19	advmod	_	_
19	implicating	implicate	VBG	VBG	_	5	xcomp	_	_
20	a	a	DT	DT	_	21	det	_	_
21	number	number	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	29	case	_	_
23	diverse	diverse	JJ	JJ	_	29	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	yet	yet	RB	RB	_	23	advmod	_	_
26	convergent	convergent	JJ	JJ	_	23	dep	_	_
27	signal	signal	NN	NN	_	29	compound	_	_
28	transduction	transduction	NN	NN	_	29	compound	_	_
29	pathways	pathway	NNS	NNS	_	21	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
32	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
33	control	control	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	I	I	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	how	how	WRB	WRB	_	16	advmod	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	methylation	methylation	NN	NN	_	16	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	specific	specific	JJ	JJ	_	14	amod	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	9	conj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	regulate	regulate	VB	VB	_	6	ccomp	_	_
17	transcription	transcription	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	response	response	NN	NN	_	26	dep	_	_
24	to	to	TO	TO	_	26	case	_	_
25	extracellular	extracellular	JJ	JJ	_	26	amod	_	_
26	signals	signal	NNS	NNS	_	16	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Inorganic	inorganic	JJ	JJ	_	2	amod	_	_
2	lead	lead	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	primary	primary	JJ	JJ	_	11	amod	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	CD4+	cd4+	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Inorganic	inorganic	JJ	JJ	_	2	amod	_	_
2	lead	lead	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	Pb	pb	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	ubiquitous	ubiquitous	JJ	JJ	_	10	amod	_	_
9	environmental	environmental	JJ	JJ	_	10	amod	_	_
10	contaminant	contaminant	NN	NN	_	0	root	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	produces	produce	VBZ	VBZ	_	10	acl:relcl	_	_
13	a	a	DT	DT	_	14	det	_	_
14	variety	variety	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	effects	effect	NNS	NNS	_	14	nmod	_	_
17	on	on	IN	IN	_	23	case	_	_
18	humoral	humoral	JJ	JJ	_	23	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cell	cell	NN	NN	_	21	nmod:npmod	_	_
21	mediated	mediated	JJ	JJ	_	18	conj	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	underlying	underlie	VBG	VBG	_	4	amod	_	_
3	molecular	molecular	JJ	JJ	_	4	amod	_	_
4	mechanism	mechanism	NN	NN	_	14	nsubj	_	_
5	for	for	IN	IN	_	9	case	_	_
6	Pb	pb	NN	NN	_	9	nmod:poss	_	_
7	's	's	POS	POS	_	6	case	_	_
8	complex	complex	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	4	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	9	nmod	_	_
14	remain	remain	VBP	VBP	_	0	root	_	_
15	obscure	obscure	JJ	JJ	_	14	xcomp	_	_
16	.	.	.	.	_	14	punct	_	_

1	Many	many	JJ	JJ	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Pb	pb	NN	NN	_	5	nmod:poss	_	_
4	's	's	POS	POS	_	3	case	_	_
5	effects	effect	NNS	NNS	_	1	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	5	nmod	_	_
10	could	could	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	explained	explain	VBN	VBN	_	0	root	_	_
13	through	through	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	18	appos	_	_
22	.	.	.	.	_	12	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	critical	critical	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	strong	strong	JJ	JJ	_	13	amod	_	_
13	inducer	inducer	NN	NN	_	4	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HIV-LTR	hiv-ltr	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	Pb	pb	NN	NN	_	9	nsubj	_	_
5	at	at	IN	IN	_	8	case	_	_
6	physiologically	physiologically	RB	RB	_	7	advmod	_	_
7	relevant	relevant	JJ	JJ	_	8	amod	_	_
8	concentrations	concentration	NNS	NNS	_	4	nmod	_	_
9	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	primary	primary	JJ	JJ	_	17	amod	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Pb-induced	pb-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	antibodies	antibody	NNS	NNS	_	7	nmod	_	_
10	for	for	IN	IN	_	14	case	_	_
11	p65	p65	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	p50	p50	NN	NN	_	11	conj	_	_
14	subunits	subunit	NNS	NNS	_	9	nmod	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	14	cc	_	_
17	cRel	crel	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	indicating	indicate	VBG	VBG	_	7	xcomp	_	_
20	that	that	IN	IN	_	29	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	p65:p50	p65:p50	NN	NN	_	23	compound	_	_
23	heterodimer	heterodimer	NN	NN	_	29	nsubjpass	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	involved	involve	VBN	VBN	_	19	ccomp	_	_
30	.	.	.	.	_	7	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	Pb	pb	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	confirmed	confirm	VBN	VBN	_	0	root	_	_
10	using	use	VBG	VBG	_	9	xcomp	_	_
11	primary	primary	JJ	JJ	_	14	amod	_	_
12	CD4+	cd4+	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	dobj	_	_
15	transfected	transfect	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	23	case	_	_
17	an	a	DT	DT	_	23	det	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	20	nmod:npmod	_	_
20	dependent	dependent	JJ	JJ	_	23	amod	_	_
21	reporter	reporter	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	construct	construct	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Pb	pb	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	activate	activate	VB	VB	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	4	4	CD	CD	_	12	nummod	_	_
9	different	different	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
15	that	that	IN	IN	_	23	mark	_	_
16	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	23	nsubj	_	_
19	may	may	MD	MD	_	23	aux	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	be	be	VB	VB	_	23	cop	_	_
22	reliable	reliable	JJ	JJ	_	23	amod	_	_
23	surrogates	surrogate	NNS	NNS	_	14	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	study	study	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	human	human	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	12	nsubj	_	_
7	may	may	MD	MD	_	12	aux	_	_
8	be	be	VB	VB	_	12	cop	_	_
9	an	a	DT	DT	_	12	det	_	_
10	important	important	JJ	JJ	_	12	amod	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	mediator	mediator	NN	NN	_	3	ccomp	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Pb-induced	pb-induced	JJ	JJ	_	15	amod	_	_
15	immunotoxicity	immunotoxicity	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Calcium-dependent	calcium-dependent	JJ	JJ	_	4	amod	_	_
2	immediate-early	immediate-early	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	9	nsubjpass	_	_
5	in	in	IN	IN	_	6	case	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	negatively	negatively	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	p21Ha-ras	p21ha-ras	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	immediate-early	immediate-early	JJ	JJ	_	9	amod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IE	ie	JJ	JJ	_	4	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	response	response	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	2	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	such	such	JJ	JJ	_	13	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	egr-1	egr-1	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	c-fos	c-fos	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	c-jun	c-jun	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	occurs	occur	VBZ	VBZ	_	0	root	_	_
21	rapidly	rapidly	RB	RB	_	20	advmod	_	_
22	after	after	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activation	activation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	process	process	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	involves	involve	VBZ	VBZ	_	0	root	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	mobilization	mobilization	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	activation	activation	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PKC	pkc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	phosphorylation	phosphorylation	NN	NN	_	7	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
22	kinases	kinase	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	p21(ras)	p21(ras)	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	guanine	guanine	NN	NN	_	7	compound	_	_
5	nucleotide	nucleotide	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	1	punct	_	_
9	mediates	mediate	VBZ	VBZ	_	0	root	_	_
10	T-cell	t-cell	NN	NN	_	12	compound	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transduction	transduction	NN	NN	_	9	dobj	_	_
13	through	through	IN	IN	_	17	case	_	_
14	PKC-dependent	pkc-dependent	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	PKC-independent	pkc-independent	JJ	JJ	_	14	conj	_	_
17	pathways	pathway	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p21(ras)	p21(ras)	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	regulation	regulation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	calcium-dependent	calcium-dependent	JJ	JJ	_	10	amod	_	_
10	signals	signal	NNS	NNS	_	7	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	suggested	suggest	VBN	VBN	_	0	root	_	_
14	through	through	IN	IN	_	15	case	_	_
15	analysis	analysis	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	role	role	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-AT	nf-at	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	inductions	induction	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IE	ie	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	response	response	NN	NN	_	14	dep	_	_
12	to	to	TO	TO	_	14	case	_	_
13	calcium	calcium	NN	NN	_	14	compound	_	_
14	signals	signal	NNS	NNS	_	5	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	Jurkat	jurkat	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	5	nmod	_	_
18	(	(	-LRB-	-LRB-	_	5	punct	_	_
19	in	in	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	dep	_	_
21	presence	presence	NN	NN	_	24	dep	_	_
22	of	of	IN	IN	_	24	case	_	_
23	activated	activate	VBN	VBN	_	24	amod	_	_
24	p21(ras)	p21(ras)	NN	NN	_	5	nmod	_	_
25	)	)	-RRB-	-RRB-	_	5	punct	_	_
26	and	and	CC	CC	_	5	cc	_	_
27	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
28	correlated	correlate	VBN	VBN	_	29	amod	_	_
29	consequences	consequence	NNS	NNS	_	5	conj	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	activated	activate	VBN	VBN	_	5	amod	_	_
5	p21(ras)	p21(ras)	NN	NN	_	2	nmod	_	_
6	negatively	negatively	RB	RB	_	7	advmod	_	_
7	regulated	regulate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IE	ie	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	calcium	calcium	NN	NN	_	15	compound	_	_
15	ionophore	ionophore	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	calcium-activated	calcium-activated	JJ	JJ	_	7	amod	_	_
5	IE	ie	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	reversed	reverse	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	treatment	treatment	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	cyclosporin	cyclosporin	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	involvement	involvement	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	calcineurin	calcineurin	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	later	later	JJ	JJ	_	3	amod	_	_
3	result	result	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	inhibition	inhibition	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	activation	activation	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	p21(ras)	p21(ras)	NN	NN	_	5	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	down-regulation	down-regulation	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	AP-1	ap-1	NN	NN	_	16	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	subsequent	subsequent	JJ	JJ	_	25	amod	_	_
24	coordinate	coordinate	JJ	JJ	_	25	amod	_	_
25	reductions	reduction	NNS	NNS	_	13	conj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	IL-2	il-2	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	protein	protein	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	p2l(ras)	p2l(ras)	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	an	a	DT	DT	_	9	det	_	_
8	essential	essential	JJ	JJ	_	9	amod	_	_
9	mediator	mediator	NN	NN	_	3	ccomp	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	generating	generate	VBG	VBG	_	9	acl	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	only	only	RB	RB	_	14	cc:preconj	_	_
14	positive	positive	JJ	JJ	_	19	amod	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	negative	negative	JJ	JJ	_	14	conj	_	_
18	modulatory	modulatory	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	11	dobj	_	_
20	controlling	control	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	competence	competence	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	response	response	NN	NN	_	30	dep	_	_
28	to	to	TO	TO	_	30	case	_	_
29	inductive	inductive	JJ	JJ	_	30	amod	_	_
30	stimulations	stimulation	NNS	NNS	_	20	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	CD14-mediated	cd14-mediated	JJ	JJ	_	3	amod	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	pathway	pathway	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	Porphyromonas	porphyromonas	NN	NN	_	7	compound	_	_
6	gingivalis	gingivalis	NN	NN	_	7	compound	_	_
7	lipopolysaccharide	lipopolysaccharide	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	gingival	gingival	JJ	JJ	_	11	amod	_	_
11	fibroblasts	fibroblast	NNS	NNS	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	LPS	lps	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	inflammatory	inflammatory	JJ	JJ	_	9	amod	_	_
9	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	6	nmod	_	_
12	via	via	IN	IN	_	13	case	_	_
13	CD14	cd14	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	one	one	CD	CD	_	13	appos	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	LPS	lps	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	expressed	express	VBN	VBN	_	13	acl:relcl	_	_
24	predominantly	predominantly	RB	RB	_	23	advmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	Porphyromonas	porphyromonas	NN	NN	_	8	compound	_	_
7	gingivalis	gingivalis	NN	NN	_	8	compound	_	_
8	LPS	lps	NN	NN	_	14	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	P-LPS	p-lps	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	able	able	JJ	JJ	_	4	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	induce	induce	VB	VB	_	14	xcomp	_	_
17	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
18	cytokines	cytokine	NNS	NNS	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	gingival	gingival	JJ	JJ	_	22	amod	_	_
22	fibroblasts	fibroblast	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	5	ccomp	_	_
8	whether	whether	IN	IN	_	11	mark	_	_
9	CD14	cd14	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	7	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	gingival	gingival	JJ	JJ	_	14	amod	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	define	define	VB	VB	_	7	conj	_	_
18	the	the	DT	DT	_	21	det	_	_
19	P-LPS-mediated	p-lps-mediated	JJ	JJ	_	21	amod	_	_
20	signal-transducing	signal-transducing	JJ	JJ	_	21	amod	_	_
21	mechanism	mechanism	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	observed	observe	VBD	VBD	_	0	root	_	_
7	unexpectedly	unexpectedly	RB	RB	_	6	advmod	_	_
8	by	by	IN	IN	_	23	case	_	_
9	immunohistochemical	immunohistochemical	JJ	JJ	_	23	amod	_	_
10	,	,	,	,	_	9	punct	_	_
11	Western	western	JJ	JJ	_	12	amod	_	_
12	blotting	blotting	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	immunoblotting	immunoblotting	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	Northern	northern	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	RNA	rna	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	blotting	blotting	NN	NN	_	9	conj	_	_
23	assays	assay	NNS	NNS	_	6	nmod	_	_
24	that	that	IN	IN	_	27	mark	_	_
25	CD14	cd14	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	expressed	express	VBN	VBN	_	6	ccomp	_	_
28	at	at	IN	IN	_	30	case	_	_
29	high	high	JJ	JJ	_	30	amod	_	_
30	density	density	NN	NN	_	27	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	gingival	gingival	JJ	JJ	_	34	amod	_	_
34	fibroblasts	fibroblast	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	P-LPS-induced	p-lps-induced	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	12	case	_	_
4	the	the	DT	DT	_	12	det	_	_
5	monocyte	monocyte	NN	NN	_	7	compound	_	_
6	chemoattractant	chemoattractant	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MCP-1	mcp-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	gene	gene	NN	NN	_	2	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	2	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	inhibited	inhibit	VBN	VBN	_	0	root	_	_
18	markedly	markedly	RB	RB	_	17	advmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	treatment	treatment	NN	NN	_	17	nmod	_	_
21	with	with	IN	IN	_	24	case	_	_
22	anti-human	anti-human	JJ	JJ	_	24	amod	_	_
23	CD14	cd14	NN	NN	_	24	compound	_	_
24	antibody	antibody	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	was	be	VBD	VBD	_	28	auxpass	_	_
27	completely	completely	RB	RB	_	28	advmod	_	_
28	inhibited	inhibit	VBN	VBN	_	17	conj	_	_
29	by	by	IN	IN	_	31	case	_	_
30	herbimycin	herbimycin	NN	NN	_	31	compound	_	_
31	A	a	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	a	a	DT	DT	_	35	det	_	_
34	potent	potent	JJ	JJ	_	35	amod	_	_
35	inhibitor	inhibitor	NN	NN	_	31	appos	_	_
36	of	of	IN	IN	_	38	case	_	_
37	tyrosine	tyrosine	NN	NN	_	38	compound	_	_
38	kinase	kinase	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibitor	inhibitor	NN	NN	_	5	nsubj	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	dramatically	dramatically	RB	RB	_	5	advmod	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	monocyte	monocyte	NN	NN	_	8	compound	_	_
7	chemotactic	chemotactic	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	8	acl	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	MCP-1	mcp-1	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	conj	_	_
13	by	by	IN	IN	_	12	acl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	8	dep	_	_
16	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	P-LPS-induced	p-lps-induced	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	14	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	MCP-1	mcp-1	JJ	JJ	_	8	amod	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	inhibitors	inhibitor	NNS	NNS	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	two	two	CD	CD	_	20	nummod	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	i.e.	i.e.	FW	FW	_	24	advmod	_	_
23	,	,	,	,	_	24	punct	_	_
24	curcumin	curcumin	NN	NN	_	20	appos	_	_
25	,	,	,	,	_	24	punct	_	_
26	an	a	DT	DT	_	27	det	_	_
27	inhibitor	inhibitor	NN	NN	_	24	appos	_	_
28	of	of	IN	IN	_	29	case	_	_
29	AP-1	ap-1	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	24	punct	_	_
31	and	and	CC	CC	_	24	cc	_	_
32	pyrolidine	pyrolidine	NN	NN	_	33	compound	_	_
33	dithiocarbamate	dithiocarbamate	NN	NN	_	24	conj	_	_
34	,	,	,	,	_	33	punct	_	_
35	an	a	DT	DT	_	36	det	_	_
36	inhibitor	inhibitor	NN	NN	_	33	appos	_	_
37	of	of	IN	IN	_	38	case	_	_
38	NF-kappaB	nf-kappab	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	inhibitors	inhibitor	NNS	NNS	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	monocyte	monocyte	NN	NN	_	6	compound	_	_
5	chemotactic	chemotactic	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	culture	culture	NN	NN	_	3	nmod	_	_
10	supernatant	supernatant	JJ	JJ	_	9	amod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	P-LPS-treated	p-lps-treated	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	shift	shift	NN	NN	_	4	compound	_	_
3	mobility	mobility	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	stimulation	stimulation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	AP-1	ap-1	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	conj	_	_
12	contents	contents	NNS	NNS	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	P-LPS-treated	p-lps-treated	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	the	the	DT	DT	_	5	det	_	_
5	first	first	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD14	cd14	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	gingival	gingival	JJ	JJ	_	15	amod	_	_
15	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	show	show	VB	VB	_	7	conj	_	_
19	that	that	IN	IN	_	29	mark	_	_
20	the	the	DT	DT	_	22	det	_	_
21	signal-transducing	signal-transducing	JJ	JJ	_	22	amod	_	_
22	pathway	pathway	NN	NN	_	29	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	P-LPS	p-lps	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	mediated	mediate	VBN	VBN	_	18	ccomp	_	_
30	by	by	IN	IN	_	31	case	_	_
31	CD14	cd14	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
4	signal	signal	NN	NN	_	6	compound	_	_
5	transduction	transduction	NN	NN	_	6	compound	_	_
6	molecules	molecule	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	PBMC	pbmc	NN	NN	_	1	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	rhesus	rhesus	NN	NN	_	11	compound	_	_
11	macaques	macaque	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sooty	sooty	JJ	JJ	_	14	amod	_	_
14	mangabeys	mangabey	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	1	punct	_	_

1	One	one	CD	CD	_	18	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	manifestations	manifestation	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	HIV-1	hiv-1	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	nonhuman	nonhuman	JJ	JJ	_	10	amod	_	_
10	primate	primate	JJ	JJ	_	11	amod	_	_
11	SIV	siv	NN	NN	_	7	conj	_	_
12	infection	infection	NN	NN	_	7	dep	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	lead	lead	VBP	VBP	_	7	acl:relcl	_	_
15	to	to	TO	TO	_	16	case	_	_
16	disease	disease	NN	NN	_	14	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	reasoned	reason	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	secondary	secondary	JJ	JJ	_	18	xcomp	_	_
22	to	to	TO	TO	_	25	case	_	_
23	generalized	generalize	VBN	VBN	_	25	amod	_	_
24	T-cell	t-cell	NN	NN	_	25	compound	_	_
25	dysfunction	dysfunction	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	9	nsubj	_	_
4	associated	associate	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	dysfunction	dysfunction	NN	NN	_	4	nmod	_	_
9	remain	remain	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	elucidated	elucidate	VBN	VBN	_	9	xcomp	_	_
13	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	issue	issue	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	sought	seek	VBD	VBD	_	2	parataxis	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	utilize	utilize	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	13	det	_	_
11	nonhuman	nonhuman	JJ	JJ	_	12	amod	_	_
12	primate	primate	JJ	JJ	_	13	amod	_	_
13	model	model	NN	NN	_	9	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	study	study	VB	VB	_	7	xcomp	_	_
16	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	events	event	NNS	NNS	_	15	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	18	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	disease-susceptible	disease-susceptible	JJ	JJ	_	24	amod	_	_
23	rhesus	rhesus	NN	NN	_	24	compound	_	_
24	macaques	macaque	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	disease-resistant	disease-resistant	JJ	JJ	_	27	amod	_	_
27	sooty	sooty	JJ	JJ	_	28	amod	_	_
28	mangabeys	mangabey	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	relatively	relatively	RB	RB	_	3	advmod	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	15	advcl	_	_
6	about	about	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	events	event	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	nonhuman	nonhuman	JJ	JJ	_	11	amod	_	_
11	primates	primate	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	our	we	PRP$	PRP$	_	14	nmod:poss	_	_
14	laboratory	laboratory	NN	NN	_	15	nsubj	_	_
15	defined	define	VBD	VBD	_	0	root	_	_
16	optimal	optimal	JJ	JJ	_	17	amod	_	_
17	conditions	condition	NNS	NNS	_	15	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	reagents	reagent	NNS	NNS	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	assays	assay	NNS	NNS	_	17	conj	_	_
23	for	for	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	study	study	NN	NN	_	15	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	signal	signal	NN	NN	_	29	compound	_	_
28	transduction	transduction	NN	NN	_	29	compound	_	_
29	events	event	NNS	NNS	_	25	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	cells	cell	NNS	NNS	_	29	nmod	_	_
32	from	from	IN	IN	_	34	case	_	_
33	nonhuman	nonhuman	JJ	JJ	_	34	amod	_	_
34	primates	primate	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	protein	protein	NN	NN	_	4	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	4	compound	_	_
4	patterns	pattern	NNS	NNS	_	9	nsubj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	monkeys	monkey	NNS	NNS	_	4	nmod	_	_
9	exhibited	exhibit	VBD	VBD	_	0	root	_	_
10	quantitative	quantitative	JJ	JJ	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	qualitative	qualitative	JJ	JJ	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	kinetic	kinetic	JJ	JJ	_	10	conj	_	_
16	differences	difference	NNS	NNS	_	10	dep	_	_
17	.	.	.	.	_	9	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	Stat6	stat6	NN	NN	_	1	nmod	_	_
4	detected	detect	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	unique	unique	JJ	JJ	_	7	amod	_	_
7	band	band	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	macaque	macaque	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lysates	lysate	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	band	band	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	markedly	markedly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBN	VBN	_	0	root	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lysates	lysate	NNS	NNS	_	5	dobj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	never	never	RB	RB	_	11	neg	_	_
11	seen	see	VBN	VBN	_	5	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	mangabey	mangabey	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lysates	lysate	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Detection	detection	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	various	various	JJ	JJ	_	4	amod	_	_
4	other	other	JJ	JJ	_	7	amod	_	_
5	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	1	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	described	describe	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Tyrosines	tyrosine	NNS	NNS	_	11	nsubjpass	_	_
2	113	113	CD	CD	_	1	dep	_	_
3	,	,	,	,	_	2	punct	_	_
4	128	128	CD	CD	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	145	145	CD	CD	_	2	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	SLP-76	slp-76	NN	NN	_	1	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	optimal	optimal	JJ	JJ	_	14	amod	_	_
14	augmentation	augmentation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	NFAT	nfat	NN	NN	_	18	compound	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	SLP-76	slp-76	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	6	punct	_	_
3	SH2	sh2	NN	NN	_	6	compound	_	_
4	domain	domain	NN	NN	_	6	compound	_	_
5	leukocyte	leukocyte	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	dep	_	_
7	of	of	IN	IN	_	9	case	_	_
8	76	76	CD	CD	_	9	nummod	_	_
9	kDa	kda	NN	NN	_	6	nmod	_	_
10	)	)	-RRB-	-RRB-	_	6	punct	_	_
11	is	be	VBZ	VBZ	_	15	cop	_	_
12	a	a	DT	DT	_	15	det	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	15	amod	_	_
15	substrate	substrate	NN	NN	_	0	root	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	TCR-stimulated	tcr-stimulated	JJ	JJ	_	21	amod	_	_
19	protein	protein	NN	NN	_	21	compound	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	kinases	kinase	NNS	NNS	_	15	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	functions	function	VBZ	VBZ	_	15	acl:relcl	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	signal	signal	NN	NN	_	28	compound	_	_
27	transduction	transduction	NN	NN	_	28	compound	_	_
28	cascade	cascade	NN	NN	_	23	nmod	_	_
29	linking	link	VBG	VBG	_	28	acl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	TCR	tcr	NN	NN	_	29	dobj	_	_
32	with	with	IN	IN	_	35	case	_	_
33	IL-2	il-2	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	engagement	engagement	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	TCR	tcr	NN	NN	_	8	nmod	_	_
12	results	result	VBZ	VBZ	_	6	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	SLP-76	slp-76	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	amino-terminal	amino-terminal	JJ	JJ	_	22	amod	_	_
21	acidic	acidic	JJ	JJ	_	22	amod	_	_
22	region	region	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	tyrosines	tyrosine	NNS	NNS	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	Y113	y113	NN	NN	_	2	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Y128	y128	NN	NN	_	4	conj	_	_
7	)	)	-RRB-	-RRB-	_	4	punct	_	_
8	fall	fall	VBP	VBP	_	0	root	_	_
9	within	within	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	identical	identical	JJ	JJ	_	14	amod	_	_
12	five	five	CD	CD	_	14	nummod	_	_
13	amino-acid	amino-acid	JJ	JJ	_	14	amod	_	_
14	motif	motif	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	shown	show	VBN	VBN	_	8	conj	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	phosphorylated	phosphorylate	VBN	VBN	_	17	dep	_	_
21	upon	upon	IN	IN	_	23	case	_	_
22	TCR	tcr	NN	NN	_	23	compound	_	_
23	ligation	ligation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	mutation	mutation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	either	either	CC	CC	_	5	cc:preconj	_	_
5	Y113	y113	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Y128	y128	NN	NN	_	5	conj	_	_
8	has	have	VBZ	VBZ	_	20	advcl	_	_
9	a	a	DT	DT	_	11	det	_	_
10	minimal	minimal	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	SLP-76	slp-76	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	20	punct	_	_
16	mutation	mutation	NN	NN	_	20	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	both	both	DT	DT	_	19	det	_	_
19	residues	residue	NNS	NNS	_	16	nmod	_	_
20	decreases	decrease	VBZ	VBZ	_	0	root	_	_
21	significantly	significantly	RB	RB	_	20	advmod	_	_
22	the	the	DT	DT	_	23	det	_	_
23	ability	ability	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	SLP-76	slp-76	NN	NN	_	23	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	promote	promote	VB	VB	_	23	acl	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	third	third	JJ	JJ	_	3	amod	_	_
3	tyrosine	tyrosine	NN	NN	_	11	nsubj	_	_
4	within	within	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	amino-terminal	amino-terminal	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	Y145	y145	NN	NN	_	3	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	appears	appear	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	16	mark	_	_
13	be	be	VB	VB	_	16	cop	_	_
14	the	the	DT	DT	_	16	det	_	_
15	most	most	RBS	RBS	_	16	advmod	_	_
16	important	important	JJ	JJ	_	11	xcomp	_	_
17	for	for	IN	IN	_	20	case	_	_
18	optimal	optimal	JJ	JJ	_	20	amod	_	_
19	SLP-76	slp-76	NN	NN	_	20	compound	_	_
20	function	function	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	16	punct	_	_
22	as	as	IN	IN	_	28	mark	_	_
23	altering	alter	VBG	VBG	_	28	csubj	_	_
24	it	it	PRP	PRP	_	23	dobj	_	_
25	alone	alone	RB	RB	_	24	advmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	phenylalanine	phenylalanine	NN	NN	_	23	nmod	_	_
28	has	have	VBZ	VBZ	_	16	advcl	_	_
29	a	a	DT	DT	_	31	det	_	_
30	potent	potent	JJ	JJ	_	31	amod	_	_
31	impact	impact	NN	NN	_	28	dobj	_	_
32	on	on	IN	IN	_	34	case	_	_
33	SLP-76	slp-76	NN	NN	_	34	compound	_	_
34	augmentation	augmentation	NN	NN	_	28	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	NFAT	nfat	NN	NN	_	38	compound	_	_
37	promoter	promoter	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	catalytic	catalytic	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	pp56(lck)	pp56(lck)	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	3	cc	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	3	conj	_	_
12	,	,	,	,	_	3	punct	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	sufficient	sufficient	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	16	mark	_	_
16	inducing	induce	VBG	VBG	_	14	advcl	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	lymphoid	lymphoid	JJ	JJ	_	5	amod	_	_
3	src	src	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	pp56(lck)	pp56(lck)	NN	NN	_	8	nsubjpass	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	essential	essential	JJ	JJ	_	8	xcomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	different	different	JJ	JJ	_	19	amod	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	responses	response	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	CD4-mediated	cd4-mediated	JJ	JJ	_	23	amod	_	_
23	enhancement	enhancement	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	Ag-induced	ag-induced	JJ	JJ	_	28	amod	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	23	punct	_	_
30	early	early	JJ	JJ	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	differentiation	differentiation	NN	NN	_	23	conj	_	_
34	,	,	,	,	_	23	punct	_	_
35	induction	induction	NN	NN	_	23	conj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	IL-2	il-2	NN	NN	_	38	compound	_	_
38	production	production	NN	NN	_	35	nmod	_	_
39	,	,	,	,	_	23	punct	_	_
40	and	and	CC	CC	_	23	cc	_	_
41	cytotoxicity	cytotoxicity	NN	NN	_	23	conj	_	_
42	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	assumed	assume	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	pp56(lck)	pp56(lck)	NN	NN	_	6	nsubj	_	_
6	acts	act	VBZ	VBZ	_	3	ccomp	_	_
7	on	on	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	processes	process	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	phosphorylating	phosphorylate	VBG	VBG	_	6	advcl	_	_
12	substrates	substrate	NNS	NNS	_	11	dobj	_	_
13	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	it	it	PRP	PRP	_	7	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	7	aux	_	_
5	been	be	VBN	VBN	_	7	auxpass	_	_
6	recently	recently	RB	RB	_	7	advmod	_	_
7	reported	report	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	NH2	nh2	NN	NN	_	12	compound	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	sufficient	sufficient	JJ	JJ	_	7	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	mediate	mediate	VB	VB	_	14	xcomp	_	_
17	CD4	cd4	NN	NN	_	19	compound	_	_
18	accessory	accessory	JJ	JJ	_	19	amod	_	_
19	function	function	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	address	address	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	contribution	contribution	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	catalytic	catalytic	JJ	JJ	_	10	conj	_	_
13	domains	domain	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	pp56(lck)	pp56(lck)	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	another	another	DT	DT	_	18	det	_	_
18	function	function	NN	NN	_	7	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	enzyme	enzyme	NN	NN	_	18	nmod	_	_
22	independent	independent	JJ	JJ	_	18	amod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	CD4	cd4	NN	NN	_	22	nmod	_	_
25	:	:	:	:	_	7	punct	_	_
26	TCR-induced	tcr-induced	JJ	JJ	_	28	amod	_	_
27	IL-2	il-2	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	7	dep	_	_
29	.	.	.	.	_	5	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	pp56(lck)	pp56(lck)	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	17	nsubjpass	_	_
4	lacking	lack	VBG	VBG	_	3	acl	_	_
5	either	either	CC	CC	_	9	cc:preconj	_	_
6	the	the	DT	DT	_	9	det	_	_
7	entire	entire	JJ	JJ	_	9	amod	_	_
8	catalytic	catalytic	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	4	dobj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	15	det	_	_
12	entire	entire	JJ	JJ	_	15	amod	_	_
13	NH2	nh2	NN	NN	_	15	compound	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	domain	domain	NN	NN	_	9	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	generated	generate	VBN	VBN	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	abilities	ability	NNS	NNS	_	43	nsubjpass	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	trigger	trigger	VB	VB	_	21	acl	_	_
24	transactivation	transactivation	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	37	case	_	_
26	the	the	DT	DT	_	37	det	_	_
27	TCR-regulated	tcr-regulated	JJ	JJ	_	37	amod	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	factor	factor	NN	NN	_	37	compound	_	_
30	of	of	IN	IN	_	33	case	_	_
31	activated	activate	VBN	VBN	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	NF-AT	nf-at	NN	NN	_	29	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	region	region	NN	NN	_	24	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	IL-2	il-2	NN	NN	_	41	compound	_	_
41	promoter	promoter	NN	NN	_	37	nmod	_	_
42	were	be	VBD	VBD	_	43	auxpass	_	_
43	compared	compare	VBN	VBN	_	17	conj	_	_
44	.	.	.	.	_	17	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	catalytic	catalytic	JJ	JJ	_	15	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	3	cc	_	_
7	the	the	DT	DT	_	8	det	_	_
8	NH2	nh2	NN	NN	_	3	conj	_	_
9	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
10	,	,	,	,	_	3	punct	_	_
11	domain	domain	NN	NN	_	3	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	pp56(lck)	pp56(lck)	NN	NN	_	3	nmod	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	able	able	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	15	dep	_	_
18	NF-AT	nf-at	NN	NN	_	20	compound	_	_
19	region	region	NN	NN	_	20	compound	_	_
20	transactivation	transactivation	NN	NN	_	17	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	own	own	JJ	JJ	_	17	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	cooperate	cooperate	VB	VB	_	17	conj	_	_
27	with	with	IN	IN	_	30	case	_	_
28	other	other	JJ	JJ	_	30	amod	_	_
29	intracellular	intracellular	JJ	JJ	_	30	amod	_	_
30	signals	signal	NNS	NNS	_	26	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	trigger	trigger	VB	VB	_	26	xcomp	_	_
33	this	this	DT	DT	_	34	det	_	_
34	response	response	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	15	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	catalytic	catalytic	JJ	JJ	_	5	amod	_	_
5	domain	domain	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	pp56(lck)	pp56(lck)	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	able	able	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	9	xcomp	_	_
12	IL-2	il-2	NN	NN	_	14	compound	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	an	a	DT	DT	_	17	det	_	_
17	extent	extent	NN	NN	_	11	nmod	_	_
18	similar	similar	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	that	that	DT	DT	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	wild-type	wild-type	JJ	JJ	_	23	amod	_	_
23	pp56(lck)	pp56(lck)	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	different	different	JJ	JJ	_	5	amod	_	_
5	domains	domain	NNS	NNS	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	pp56(lck)	pp56(lck)	NN	NN	_	9	compound	_	_
9	molecule	molecule	NN	NN	_	5	nmod	_	_
10	contribute	contribute	VBP	VBP	_	2	ccomp	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	regulate	regulate	VB	VB	_	10	xcomp	_	_
13	distinct	distinct	JJ	JJ	_	15	amod	_	_
14	biologic	biologic	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	12	dobj	_	_
16	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	while	while	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	NH2	nh2	NN	NN	_	8	compound	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	sufficient	sufficient	JJ	JJ	_	18	advcl	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	mediate	mediate	VB	VB	_	10	xcomp	_	_
13	CD4	cd4	NN	NN	_	15	compound	_	_
14	accessory	accessory	JJ	JJ	_	15	amod	_	_
15	function	function	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	show	show	VBP	VBP	_	0	root	_	_
19	here	here	RB	RB	_	18	advmod	_	_
20	that	that	IN	IN	_	27	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	catalytic	catalytic	JJ	JJ	_	23	amod	_	_
23	domain	domain	NN	NN	_	27	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	pp56(lck)	pp56(lck)	NN	NN	_	23	nmod	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	sufficient	sufficient	JJ	JJ	_	18	ccomp	_	_
28	for	for	IN	IN	_	29	case	_	_
29	induction	induction	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	IL-2	il-2	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	27	punct	_	_
34	mimicking	mimic	VBG	VBG	_	27	dep	_	_
35	TCR	tcr	NN	NN	_	36	compound	_	_
36	ligation	ligation	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	18	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	murine	murine	JJ	JJ	_	6	amod	_	_
6	fra-1	fra-1	NN	NN	_	1	nmod	_	_
7	:	:	:	:	_	1	punct	_	_
8	induction	induction	NN	NN	_	19	nsubj	_	_
9	mediated	mediate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	CD40	cd40	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	Ig	ig	NN	NN	_	11	conj	_	_
15	is	be	VBZ	VBZ	_	19	cop	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	19	nmod:npmod	_	_
19	dependent	dependent	JJ	JJ	_	1	dep	_	_
20	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	murine	murine	JJ	JJ	_	4	amod	_	_
3	fra-1	fra-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	12	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	encoding	encode	VBG	VBG	_	4	acl	_	_
7	Fos-related	fos-related	JJ	JJ	_	8	amod	_	_
8	Ag	ag	NN	NN	_	6	dobj	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	,	,	,	,	_	4	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	isolated	isolate	VBN	VBN	_	0	root	_	_
13	from	from	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	splenic	splenic	JJ	JJ	_	17	amod	_	_
16	cDNA	cdna	NN	NN	_	17	compound	_	_
17	library	library	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	sequenced	sequence	VBN	VBN	_	12	conj	_	_
20	.	.	.	.	_	12	punct	_	_

1	Murine	murine	JJ	JJ	_	2	amod	_	_
2	fra-1	fra-1	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	highly	highly	RB	RB	_	5	advmod	_	_
5	homologous	homologous	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	rat	rat	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	human	human	JJ	JJ	_	7	conj	_	_
10	fra-1	fra-1	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Oligonucleotide	oligonucleotide	NN	NN	_	2	compound	_	_
2	primers	primer	NNS	NNS	_	9	nsubjpass	_	_
3	based	base	VBN	VBN	_	7	case	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	murine	murine	JJ	JJ	_	7	amod	_	_
7	sequence	sequence	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	construct	construct	VB	VB	_	9	xcomp	_	_
12	a	a	DT	DT	_	16	det	_	_
13	quantitative	quantitative	JJ	JJ	_	16	amod	_	_
14	reverse	reverse	NN	NN	_	16	compound	_	_
15	transcription-PCR	transcription-pcr	NN	NN	_	16	compound	_	_
16	assay	assay	NN	NN	_	11	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	B	b	NN	NN	_	3	compound	_	_
2	lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	15	nsubj	_	_
4	via	via	IN	IN	_	13	case	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	CD40	cd40	NN	NN	_	13	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	surface	surface	NN	NN	_	9	compound	_	_
9	Ig	ig	NN	NN	_	6	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	sIg	sig	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	receptors	receptor	NNS	NNS	_	3	nmod	_	_
14	substantially	substantially	RB	RB	_	15	advmod	_	_
15	induced	induce	VBD	VBD	_	0	root	_	_
16	fra-1	fra-1	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	for	for	IN	IN	_	22	case	_	_
21	both	both	DT	DT	_	22	det	_	_
22	receptors	receptor	NNS	NNS	_	32	nmod	_	_
23	,	,	,	,	_	32	punct	_	_
24	induction	induction	NN	NN	_	32	nsubj	_	_
25	was	be	VBD	VBD	_	32	cop	_	_
26	protein	protein	NN	NN	_	28	compound	_	_
27	kinase	kinase	NN	NN	_	28	compound	_	_
28	C	c	NN	NN	_	32	nmod:npmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PKC	pkc	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	dependent	dependent	JJ	JJ	_	15	conj	_	_
33	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	contrasts	contrast	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	induction	induction	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	c-fos	c-fos	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	CD40	cd40	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	sIg	sig	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	4	punct	_	_
13	which	which	WDT	WDT	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	PKC	pkc	NN	NN	_	16	nmod:npmod	_	_
16	independent	independent	JJ	JJ	_	4	acl:relcl	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	indicates	indicate	VBZ	VBZ	_	16	conj	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	CD40	cd40	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	capable	capable	JJ	JJ	_	18	ccomp	_	_
23	of	of	IN	IN	_	24	mark	_	_
24	signaling	signal	VBG	VBG	_	22	advcl	_	_
25	through	through	IN	IN	_	26	case	_	_
26	PKC	pkc	NN	NN	_	24	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	a	a	DT	DT	_	31	det	_	_
29	closely	closely	RB	RB	_	30	advmod	_	_
30	related	related	JJ	JJ	_	31	amod	_	_
31	kinase	kinase	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	2	punct	_	_

1	Induction	induction	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	fra-1	fra-1	NN	NN	_	1	nmod	_	_
4	following	follow	VBG	VBG	_	5	case	_	_
5	engagement	engagement	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CD40	cd40	NN	NN	_	5	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	require	require	VB	VB	_	0	root	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	10	punct	_	_
14	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
15	that	that	IN	IN	_	24	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	PKC-dependent	pkc-dependent	JJ	JJ	_	18	amod	_	_
18	linkage	linkage	NN	NN	_	24	nsubj	_	_
19	between	between	IN	IN	_	20	case	_	_
20	CD40	cd40	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	fra-1	fra-1	NN	NN	_	20	conj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	direct	direct	JJ	JJ	_	14	ccomp	_	_
25	.	.	.	.	_	10	punct	_	_

1	CD40-mediated	cd40-mediated	JJ	JJ	_	3	amod	_	_
2	fra-1	fra-1	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	5	nsubj	_	_
4	did	do	VBD	VBD	_	5	aux	_	_
5	require	require	VB	VB	_	0	root	_	_
6	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	CD40	cd40	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	11	punct	_	_
7	like	like	IN	IN	_	8	case	_	_
8	sIg	sig	NN	NN	_	11	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	employ	employ	VB	VB	_	3	ccomp	_	_
12	PKC	pkc	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	producing	produce	VBG	VBG	_	11	advcl	_	_
15	select	select	JJ	JJ	_	16	amod	_	_
16	outcomes	outcome	NNS	NNS	_	14	dobj	_	_
17	,	,	,	,	_	11	punct	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	individual	individual	JJ	JJ	_	22	amod	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	receptors	receptor	NNS	NNS	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	signal	signal	VB	VB	_	11	conj	_	_
25	downstream	downstream	JJ	JJ	_	26	amod	_	_
26	events	event	NNS	NNS	_	24	dobj	_	_
27	via	via	IN	IN	_	32	case	_	_
28	both	both	CC	CC	_	29	cc:preconj	_	_
29	PKC-dependent	pkc-dependent	JJ	JJ	_	32	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	PKC-independent	pkc-independent	JJ	JJ	_	29	conj	_	_
32	pathways	pathway	NNS	NNS	_	24	nmod	_	_
33	,	,	,	,	_	11	punct	_	_
34	and	and	CC	CC	_	11	cc	_	_
35	that	that	IN	IN	_	42	mark	_	_
36	multiple	multiple	JJ	JJ	_	39	amod	_	_
37	signal	signal	NN	NN	_	39	compound	_	_
38	transduction	transduction	NN	NN	_	39	compound	_	_
39	pathways	pathway	NNS	NNS	_	42	nsubjpass	_	_
40	may	may	MD	MD	_	42	aux	_	_
41	be	be	VB	VB	_	42	auxpass	_	_
42	used	use	VBN	VBN	_	11	conj	_	_
43	to	to	TO	TO	_	44	mark	_	_
44	activate	activate	VB	VB	_	42	xcomp	_	_
45	the	the	DT	DT	_	46	det	_	_
46	expression	expression	NN	NN	_	44	dobj	_	_
47	of	of	IN	IN	_	50	case	_	_
48	closely	closely	RB	RB	_	49	advmod	_	_
49	related	related	JJ	JJ	_	50	amod	_	_
50	genes	gene	NNS	NNS	_	46	nmod	_	_
51	.	.	.	.	_	3	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	compound	_	_
2	signaling	signaling	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	normal	normal	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	:	:	:	:	_	3	punct	_	_
9	differential	differential	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	3	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Bcl-2	bcl-2	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL-1beta-converting	il-1beta-converting	JJ	JJ	_	18	amod	_	_
15	enzyme	enzyme	NN	NN	_	18	compound	_	_
16	family	family	NN	NN	_	18	compound	_	_
17	protease	protease	NN	NN	_	18	compound	_	_
18	inhibitors	inhibitor	NNS	NNS	_	12	conj	_	_
19	on	on	IN	IN	_	23	case	_	_
20	glucocorticoid-	glucocorticoid-	NN	NN	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Fas-mediated	fas-mediated	JJ	JJ	_	20	conj	_	_
23	cytotoxicity	cytotoxicity	NN	NN	_	10	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Fas-mediated	fas-mediated	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	3	nsubj	_	_
3	plays	play	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	regulating	regulate	VBG	VBG	_	3	advcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Restimulation	restimulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	blasts	blast	NNS	NNS	_	1	nmod	_	_
6	up-regulates	up-regulate	VBZ	VBZ	_	0	root	_	_
7	Fas	fas	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Fas	fas	NN	NN	_	11	compound	_	_
10	ligand	ligand	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	with	with	IN	IN	_	16	mark	_	_
14	subsequent	subsequent	JJ	JJ	_	15	amod	_	_
15	interaction	interaction	NN	NN	_	16	nsubj	_	_
16	leading	lead	VBG	VBG	_	6	advcl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	death	death	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Overexpression	overexpression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Bcl-2	bcl-2	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	tumor	tumor	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	blocks	block	VBZ	VBZ	_	0	root	_	_
8	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	many	many	JJ	JJ	_	12	amod	_	_
12	stimuli	stimulus	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	but	but	CC	CC	_	7	cc	_	_
15	inhibition	inhibition	NN	NN	_	23	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Fas-mediated	fas-mediated	JJ	JJ	_	18	amod	_	_
18	killing	killing	NN	NN	_	15	nmod	_	_
19	has	have	VBZ	VBZ	_	23	aux	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	been	be	VBN	VBN	_	23	auxpass	_	_
22	consistently	consistently	RB	RB	_	23	advmod	_	_
23	observed	observe	VBN	VBN	_	7	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	16	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	behavior	behavior	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Bcl-2	bcl-2	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	normal	normal	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	,	,	,	,	_	16	punct	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	blasts	blast	NNS	NNS	_	16	nsubjpass	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	transiently	transiently	RB	RB	_	16	advmod	_	_
16	transfected	transfect	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	18	case	_	_
18	Bcl-2	bcl-2	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	related	related	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	products	product	NNS	NNS	_	18	conj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	determine	determine	VB	VB	_	16	xcomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	effect	effect	NN	NN	_	24	dobj	_	_
27	on	on	IN	IN	_	29	case	_	_
28	apoptotic	apoptotic	JJ	JJ	_	29	amod	_	_
29	signaling	signaling	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	overexpression	overexpression	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Bcl-2	bcl-2	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	11	case	_	_
6	mouse	mouse	NN	NN	_	11	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	human	human	JJ	JJ	_	6	conj	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	blasts	blast	NNS	NNS	_	2	nmod	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	block	block	VB	VB	_	0	root	_	_
15	Fas-mediated	fas-mediated	JJ	JJ	_	16	amod	_	_
16	apoptosis	apoptosis	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	14	punct	_	_
18	whereas	whereas	IN	IN	_	14	dep	_	_
19	etoposide-	etoposide-	NN	NN	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	19	conj	_	_
22	cytotoxicity	cytotoxicity	NN	NN	_	25	nsubjpass	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	potently	potently	RB	RB	_	25	advmod	_	_
25	inhibited	inhibit	VBN	VBN	_	14	parataxis	_	_
26	.	.	.	.	_	14	punct	_	_

1	Expression	expression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Bcl-xL	bcl-xl	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	adenovirus	adenovirus	NN	NN	_	7	compound	_	_
6	E1B	e1b	NN	NN	_	7	compound	_	_
7	19K	19k	NN	NN	_	3	conj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	interfere	interfere	VB	VB	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	anti-Fas	anti-fas	JJ	JJ	_	13	amod	_	_
13	killing	killing	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	interleukin-1beta-converting	interleukin-1beta-converting	JJ	JJ	_	8	amod	_	_
5	enzyme	enzyme	NN	NN	_	8	compound	_	_
6	family	family	NN	NN	_	8	compound	_	_
7	protease	protease	NN	NN	_	8	compound	_	_
8	inhibitors	inhibitor	NNS	NNS	_	12	nsubj	_	_
9	Ac-DEVD-CHO	ac-devd-cho	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CrmA	crma	NN	NN	_	9	conj	_	_
12	blocked	block	VBD	VBD	_	0	root	_	_
13	Fas-mediated	fas-mediated	JJ	JJ	_	14	amod	_	_
14	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	use	use	VBP	VBP	_	3	ccomp	_	_
9	distinct	distinct	JJ	JJ	_	12	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	12	compound	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	8	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	differential	differential	JJ	JJ	_	15	amod	_	_
15	sensitivity	sensitivity	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	Bcl-2	bcl-2	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	interleukin-1beta-converting	interleukin-1beta-converting	JJ	JJ	_	23	amod	_	_
20	enzyme	enzyme	NN	NN	_	23	compound	_	_
21	family	family	NN	NN	_	23	compound	_	_
22	protease	protease	NN	NN	_	23	compound	_	_
23	inhibitors	inhibitor	NNS	NNS	_	17	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	normally	normally	RB	RB	_	5	advmod	_	_
5	express	express	VBP	VBP	_	19	advcl	_	_
6	Bcl-2	bcl-2	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Bcl-xL	bcl-xl	NN	NN	_	6	conj	_	_
9	following	follow	VBG	VBG	_	10	case	_	_
10	activation	activation	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	19	punct	_	_
12	their	they	PRP$	PRP$	_	13	nmod:poss	_	_
13	inability	inability	NN	NN	_	19	nsubj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	block	block	VB	VB	_	13	acl	_	_
16	Fas-mediated	fas-mediated	JJ	JJ	_	17	amod	_	_
17	apoptosis	apoptosis	NN	NN	_	15	dobj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	allow	allow	VB	VB	_	0	root	_	_
20	for	for	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	elimination	elimination	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	self-reactive	self-reactive	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	appropriate	appropriate	JJ	JJ	_	29	amod	_	_
29	regulation	regulation	NN	NN	_	22	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	immune	immune	JJ	JJ	_	32	amod	_	_
32	responses	response	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	Comparative	comparative	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	identifies	identify	VBZ	VBZ	_	0	root	_	_
4	conserved	conserve	VBN	VBN	_	12	amod	_	_
5	tumor	tumor	NN	NN	_	8	nmod:npmod	_	_
6	necrosis	necrosis	NN	NN	_	8	nmod:npmod	_	_
7	factor	factor	NN	NN	_	8	nmod:npmod	_	_
8	receptor-associated	receptor-associated	JJ	JJ	_	12	amod	_	_
9	factor	factor	NN	NN	_	12	compound	_	_
10	3	3	CD	CD	_	12	nummod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	3	dobj	_	_
13	in	in	IN	IN	_	21	case	_	_
14	the	the	DT	DT	_	21	det	_	_
15	human	human	JJ	JJ	_	21	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	simian	simian	JJ	JJ	_	15	conj	_	_
18	Epstein-Barr	epstein-barr	JJ	JJ	_	21	amod	_	_
19	virus	virus	NN	NN	_	21	compound	_	_
20	oncogene	oncogene	NN	NN	_	21	compound	_	_
21	LMP1	lmp1	NN	NN	_	12	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Nonhuman	nonhuman	JJ	JJ	_	2	amod	_	_
2	primates	primate	NNS	NNS	_	5	nsubjpass	_	_
3	are	be	VBP	VBP	_	5	auxpass	_	_
4	naturally	naturally	RB	RB	_	5	advmod	_	_
5	infected	infect	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	B-lymphotropic	b-lymphotropic	JJ	JJ	_	9	amod	_	_
9	herpesvirus	herpesvirus	NN	NN	_	5	nmod	_	_
10	closely	closely	RB	RB	_	11	advmod	_	_
11	related	related	JJ	JJ	_	9	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
14	virus	virus	NN	NN	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	EBV	ebv	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	simian	simian	JJ	JJ	_	3	amod	_	_
3	EBV	ebv	NNS	NNS	_	4	nsubj	_	_
4	share	share	VBP	VBP	_	0	root	_	_
5	considerable	considerable	JJ	JJ	_	12	amod	_	_
6	genetic	genetic	JJ	JJ	_	12	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	biologic	biologic	JJ	JJ	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	epidemiologic	epidemiologic	JJ	JJ	_	6	conj	_	_
12	features	feature	NNS	NNS	_	4	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	EBV	ebv	NN	NN	_	4	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	including	include	VBG	VBG	_	19	case	_	_
18	virus-induced	virus-induced	JJ	JJ	_	19	amod	_	_
19	tumorigenesis	tumorigenesis	NN	NN	_	4	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	latent	latent	JJ	JJ	_	7	amod	_	_
4	,	,	,	,	_	3	punct	_	_
5	transformation-associated	transformation-associated	JJ	JJ	_	3	dep	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	8	nsubj	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	marked	marked	JJ	JJ	_	11	amod	_	_
10	sequence	sequence	NN	NN	_	11	compound	_	_
11	divergence	divergence	NN	NN	_	8	dobj	_	_
12	among	among	IN	IN	_	13	case	_	_
13	species	species	NNS	NNS	_	11	nmod	_	_
14	despite	despite	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	conserved	conserve	VBN	VBN	_	17	amod	_	_
17	functions	function	NNS	NNS	_	8	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	12	det	_	_
5	latent	latent	JJ	JJ	_	7	amod	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	12	compound	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LMP1	lmp1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	homologs	homolog	NNS	NNS	_	3	dobj	_	_
13	from	from	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	simian	simian	JJ	JJ	_	16	amod	_	_
16	EBV	ebv	NN	NN	_	3	nmod	_	_
17	naturally	naturally	RB	RB	_	18	advmod	_	_
18	infecting	infect	VBG	VBG	_	16	acl	_	_
19	baboons	baboon	NNS	NNS	_	18	dobj	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	cercopithicine	cercopithicine	NN	NN	_	22	compound	_	_
22	herpesvirus	herpesvirus	NN	NN	_	16	dep	_	_
23	12	12	CD	CD	_	22	nummod	_	_
24	,	,	,	,	_	22	punct	_	_
25	herpesvirus	herpesvirus	NN	NN	_	26	compound	_	_
26	papio	papio	NN	NN	_	22	appos	_	_
27	)	)	-RRB-	-RRB-	_	22	punct	_	_
28	and	and	CC	CC	_	16	cc	_	_
29	rhesus	rhesus	NN	NN	_	30	compound	_	_
30	monkeys	monkey	NNS	NNS	_	16	conj	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	cercopithicine	cercopithicine	NN	NN	_	33	compound	_	_
33	herpesvirus	herpesvirus	NN	NN	_	30	appos	_	_
34	15	15	CD	CD	_	33	nummod	_	_
35	)	)	-RRB-	-RRB-	_	33	punct	_	_
36	for	for	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	comparative	comparative	JJ	JJ	_	39	amod	_	_
39	study	study	NN	NN	_	3	nmod	_	_
40	with	with	IN	IN	_	44	case	_	_
41	the	the	DT	DT	_	44	det	_	_
42	human	human	JJ	JJ	_	44	amod	_	_
43	EBV	ebv	NN	NN	_	44	compound	_	_
44	oncogene	oncogene	NN	NN	_	39	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transmembrane	transmembrane	NN	NN	_	3	compound	_	_
3	domains	domain	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	well	well	RB	RB	_	6	advmod	_	_
6	conserved	conserve	VBN	VBN	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	6	cc	_	_
9	there	there	EX	EX	_	10	expl	_	_
10	is	be	VBZ	VBZ	_	6	conj	_	_
11	striking	striking	JJ	JJ	_	13	amod	_	_
12	sequence	sequence	NN	NN	_	13	compound	_	_
13	divergence	divergence	NN	NN	_	10	nsubj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	carboxy-terminal	carboxy-terminal	JJ	JJ	_	18	amod	_	_
17	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	13	nmod	_	_
19	essential	essential	JJ	JJ	_	18	amod	_	_
20	for	for	IN	IN	_	22	case	_	_
21	B-cell	b-cell	NN	NN	_	22	compound	_	_
22	immortalization	immortalization	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	interaction	interaction	NN	NN	_	22	conj	_	_
25	with	with	IN	IN	_	32	case	_	_
26	the	the	DT	DT	_	32	det	_	_
27	tumor	tumor	NN	NN	_	32	compound	_	_
28	necrosis	necrosis	NN	NN	_	32	compound	_	_
29	factor	factor	NN	NN	_	32	compound	_	_
30	receptor	receptor	NN	NN	_	32	compound	_	_
31	signaling	signaling	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	simian	simian	JJ	JJ	_	6	amod	_	_
5	EBV	ebv	NN	NN	_	6	compound	_	_
6	LMP1s	lmp1	NNS	NNS	_	7	nsubj	_	_
7	retain	retain	VBP	VBP	_	0	root	_	_
8	most	most	JJS	JJS	_	9	amod	_	_
9	functions	function	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	common	common	NN	NN	_	14	dep	_	_
12	with	with	IN	IN	_	14	case	_	_
13	EBV	ebv	NN	NN	_	14	compound	_	_
14	LMP1	lmp1	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	including	include	VBG	VBG	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	ability	ability	NN	NN	_	9	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	induce	induce	VB	VB	_	18	dep	_	_
21	NF-(kappa)B	nf-(kappa)b	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	bind	bind	VB	VB	_	20	conj	_	_
29	the	the	DT	DT	_	33	det	_	_
30	tumor	tumor	NN	NN	_	32	nmod:npmod	_	_
31	necrosis	necrosis	NN	NN	_	32	nmod:npmod	_	_
32	factor-associated	factor-associated	JJ	JJ	_	33	amod	_	_
33	factor	factor	NN	NN	_	28	dobj	_	_
34	3	3	CD	CD	_	33	nummod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	TRAF3	traf3	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	in	in	FW	FW	_	39	compound	_	_
39	vitro	vitro	FW	FW	_	28	advmod	_	_
40	,	,	,	,	_	20	punct	_	_
41	and	and	CC	CC	_	20	cc	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	induce	induce	VB	VB	_	20	conj	_	_
44	expression	expression	NN	NN	_	43	dobj	_	_
45	of	of	IN	IN	_	49	case	_	_
46	tumor	tumor	NN	NN	_	48	nmod:npmod	_	_
47	necrosis	necrosis	NN	NN	_	48	nmod:npmod	_	_
48	factor-responsive	factor-responsive	JJ	JJ	_	49	amod	_	_
49	genes	gene	NNS	NNS	_	44	nmod	_	_
50	,	,	,	,	_	49	punct	_	_
51	such	such	JJ	JJ	_	53	case	_	_
52	as	as	IN	IN	_	51	mwe	_	_
53	ICAM1	icam1	NN	NN	_	49	nmod	_	_
54	,	,	,	,	_	49	punct	_	_
55	in	in	IN	IN	_	58	case	_	_
56	human	human	JJ	JJ	_	58	amod	_	_
57	B	b	NN	NN	_	58	compound	_	_
58	lymphocytes	lymphocyte	NNS	NNS	_	43	nmod	_	_
59	.	.	.	.	_	7	punct	_	_

1	Multiple	multiple	JJ	JJ	_	4	amod	_	_
2	TRAF3	traf3	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	sites	site	NNS	NNS	_	12	nsubjpass	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	a	a	DT	DT	_	9	det	_	_
7	PXQXT/S	pxqxt/s	NN	NN	_	9	compound	_	_
8	core	core	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	5	dobj	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	simian	simian	JJ	JJ	_	17	amod	_	_
16	EBV	ebv	NN	NN	_	17	compound	_	_
17	LMP1s	lmp1	NNS	NNS	_	12	nmod	_	_
18	by	by	IN	IN	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	in	in	FW	FW	_	23	amod	_	_
21	vitro	vitro	FW	FW	_	20	dep	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	assay	assay	NN	NN	_	12	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	PXQXT/S-containing	pxqxt/s-containing	JJ	JJ	_	3	amod	_	_
3	sequence	sequence	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	Hodgkin	hodgkin	NN	NN	_	16	nmod:poss	_	_
14	's	's	POS	POS	_	13	case	_	_
15	disease	disease	NN	NN	_	16	compound	_	_
16	marker	marker	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	CD30	cd30	NN	NN	_	10	appos	_	_
19	,	,	,	,	_	10	punct	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	binds	bind	VBZ	VBZ	_	6	conj	_	_
22	TRAF3	traf3	NN	NN	_	21	dobj	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	21	advmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	last	last	JJ	JJ	_	5	amod	_	_
3	13	13	CD	CD	_	5	nummod	_	_
4	amino	amino	NN	NN	_	5	compound	_	_
5	acids	acid	NNS	NNS	_	12	nsubjpass	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	a	a	DT	DT	_	9	det	_	_
8	PXQXT/S	pxqxt/s	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	6	dobj	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	conserved	conserve	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	18	case	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	simian	simian	JJ	JJ	_	14	conj	_	_
17	EBV	ebv	NN	NN	_	18	compound	_	_
18	LMP1	lmp1	NN	NN	_	12	nmod	_	_
19	but	but	CC	CC	_	12	cc	_	_
20	do	do	VBP	VBP	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	bind	bind	VB	VB	_	12	conj	_	_
23	TRAF3	traf3	NN	NN	_	22	dobj	_	_
24	,	,	,	,	_	12	punct	_	_
25	suggesting	suggest	VBG	VBG	_	12	advcl	_	_
26	a	a	DT	DT	_	28	det	_	_
27	distinct	distinct	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	for	for	IN	IN	_	32	case	_	_
30	this	this	DT	DT	_	32	det	_	_
31	conserved	conserve	VBN	VBN	_	32	amod	_	_
32	region	region	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	LMP1	lmp1	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	conserved	conserve	VBN	VBN	_	5	amod	_	_
3	TRAF3	traf3	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	15	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	LMP1	lmp1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	the	the	DT	DT	_	14	det	_	_
10	CD30	cd30	NN	NN	_	14	compound	_	_
11	Hodgkin	hodgkin	NN	NN	_	14	nmod:poss	_	_
12	's	's	POS	POS	_	11	case	_	_
13	disease	disease	NN	NN	_	14	compound	_	_
14	marker	marker	NN	NN	_	5	conj	_	_
15	provides	provide	VBZ	VBZ	_	0	root	_	_
16	further	further	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	15	dobj	_	_
18	that	that	IN	IN	_	26	mark	_	_
19	a	a	DT	DT	_	23	det	_	_
20	TRAF3-mediated	traf3-mediated	JJ	JJ	_	23	amod	_	_
21	signal	signal	NN	NN	_	23	compound	_	_
22	transduction	transduction	NN	NN	_	23	compound	_	_
23	pathway	pathway	NN	NN	_	26	nsubj	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	cop	_	_
26	important	important	JJ	JJ	_	17	ccomp	_	_
27	in	in	IN	IN	_	29	case	_	_
28	malignant	malignant	JJ	JJ	_	29	amod	_	_
29	transformation	transformation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	Rapid	rapid	JJ	JJ	_	2	amod	_	_
2	shuttling	shuttling	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-AT	nf-at	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	discrimination	discrimination	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Ca2+	ca2+	NN	NN	_	9	compound	_	_
9	signals	signal	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	immunosuppression	immunosuppression	NN	NN	_	6	conj	_	_
12	.	.	.	.	_	2	punct	_	_

1	Cells	cell	NNS	NNS	_	2	nsubj	_	_
2	need	need	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	distinguish	distinguish	VB	VB	_	2	xcomp	_	_
5	between	between	IN	IN	_	8	case	_	_
6	transient	transient	JJ	JJ	_	8	amod	_	_
7	Ca2+	ca2+	NN	NN	_	8	compound	_	_
8	signals	signal	NNS	NNS	_	4	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	induce	induce	VBP	VBP	_	8	acl:relcl	_	_
11	events	event	NNS	NNS	_	10	dobj	_	_
12	such	such	JJ	JJ	_	15	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	muscle	muscle	NN	NN	_	15	compound	_	_
15	contraction	contraction	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	secretion	secretion	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	adhesion	adhesion	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	synaptic	synaptic	JJ	JJ	_	22	amod	_	_
22	transmission	transmission	NN	NN	_	15	conj	_	_
23	,	,	,	,	_	8	punct	_	_
24	and	and	CC	CC	_	8	cc	_	_
25	sustained	sustained	JJ	JJ	_	27	amod	_	_
26	Ca2+	ca2+	NN	NN	_	27	compound	_	_
27	signals	signal	NNS	NNS	_	8	conj	_	_
28	that	that	WDT	WDT	_	30	nsubjpass	_	_
29	are	be	VBP	VBP	_	30	auxpass	_	_
30	involved	involve	VBN	VBN	_	27	acl:relcl	_	_
31	in	in	IN	IN	_	32	case	_	_
32	cell	cell	NN	NN	_	30	nmod	_	_
33	proliferation	proliferation	NN	NN	_	32	dep	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	differentiation	differentiation	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	latter	latter	JJ	JJ	_	3	amod	_	_
3	class	class	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	events	event	NNS	NNS	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immunosuppressive	immunosuppressive	JJ	JJ	_	13	amod	_	_
13	drugs	drug	NNS	NNS	_	7	nmod	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	13	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	FK506	fk506	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	inhibit	inhibit	VBP	VBP	_	13	acl:relcl	_	_
21	calcineurin	calcineurin	NN	NN	_	20	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	26	det	_	_
24	Ca2+-activated	ca2+-activated	JJ	JJ	_	26	amod	_	_
25	serine/threonine	serine/threonine	NN	NN	_	26	compound	_	_
26	phosphatase	phosphatase	NN	NN	_	21	appos	_	_
27	necessary	necessary	JJ	JJ	_	26	amod	_	_
28	for	for	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	import	import	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	NF-AT	nf-at	NN	NN	_	35	compound	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	factors	factor	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	sustained	sustained	JJ	JJ	_	7	amod	_	_
6	high	high	JJ	JJ	_	7	amod	_	_
7	concentrations	concentration	NNS	NNS	_	17	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Ca2+	ca2+	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	7	cc	_	_
13	transient	transient	JJ	JJ	_	14	amod	_	_
14	pulses	pulse	NNS	NNS	_	7	conj	_	_
15	,	,	,	,	_	7	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	3	ccomp	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	maintain	maintain	VB	VB	_	17	xcomp	_	_
20	NF-AT	nf-at	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	nucleus	nucleus	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	where	where	WRB	WRB	_	29	advmod	_	_
28	they	they	PRP	PRP	_	29	nsubj	_	_
29	participate	participate	VBP	VBP	_	25	acl:relcl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	Ca2+-dependent	ca2+-dependent	JJ	JJ	_	32	amod	_	_
32	induction	induction	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	genes	gene	NNS	NNS	_	32	nmod	_	_
35	required	require	VBN	VBN	_	34	acl	_	_
36	for	for	IN	IN	_	37	case	_	_
37	lymphocyte	lymphocyte	NN	NN	_	35	nmod	_	_
38	activation	activation	NN	NN	_	37	dep	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	proliferation	proliferation	NN	NN	_	38	conj	_	_
41	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	overexpression	overexpression	NN	NN	_	25	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	localization	localization	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	23	case	_	_
9	NF-AT	nf-at	NN	NN	_	23	compound	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	Jun	jun	NN	NN	_	9	conj	_	_
14	,	,	,	,	_	13	punct	_	_
15	Fos	fos	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	Oct	oct	NN	NN	_	13	conj	_	_
20	or	or	CC	CC	_	13	cc	_	_
21	Ets	ets	NN	NN	_	13	conj	_	_
22	family	family	NN	NN	_	23	compound	_	_
23	members	member	NNS	NNS	_	3	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	renders	render	VBZ	VBZ	_	0	root	_	_
26	the	the	DT	DT	_	28	det	_	_
27	interleukin-2	interleukin-2	NN	NN	_	28	compound	_	_
28	enhancer	enhancer	NN	NN	_	33	nsubj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	Jurkat	jurkat	NN	NN	_	32	compound	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
33	resistant	resistant	JJ	JJ	_	25	xcomp	_	_
34	to	to	TO	TO	_	35	case	_	_
35	FK506	fk506	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	cyclosporin	cyclosporin	NN	NN	_	38	compound	_	_
38	A	a	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	25	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	a	a	DT	DT	_	4	det	_	_
3	primary	primary	JJ	JJ	_	4	amod	_	_
4	effect	effect	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	immunosuppressive	immunosuppressive	JJ	JJ	_	8	amod	_	_
8	reagents	reagent	NNS	NNS	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	control	control	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	subcellular	subcellular	JJ	JJ	_	14	amod	_	_
14	localization	localization	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	NF-AT	nf-at	NN	NN	_	18	compound	_	_
18	family	family	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Interferons	interferon	NNS	NNS	_	2	nsubj	_	_
2	induce	induce	VBP	VBP	_	0	root	_	_
3	normal	normal	JJ	JJ	_	9	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	aberrant	aberrant	JJ	JJ	_	3	conj	_	_
6	retinoic-acid	retinoic-acid	NN	NN	_	9	compound	_	_
7	receptors	receptor	NNS	NNS	_	9	compound	_	_
8	type	type	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	2	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	acute	acute	JJ	JJ	_	14	amod	_	_
12	promyelocytic	promyelocytic	JJ	JJ	_	14	amod	_	_
13	leukemia	leukemia	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	2	nmod	_	_
15	:	:	:	:	_	2	punct	_	_
16	potentiation	potentiation	NN	NN	_	2	dep	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	induction	induction	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	retinoid-dependent	retinoid-dependent	JJ	JJ	_	23	amod	_	_
22	differentiation	differentiation	NN	NN	_	23	compound	_	_
23	markers	marker	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	16	punct	_	_

1	Treatment	treatment	NN	NN	_	26	nsubj	_	_
2	of	of	IN	IN	_	11	case	_	_
3	the	the	DT	DT	_	11	det	_	_
4	acute	acute	JJ	JJ	_	5	amod	_	_
5	promyelocytic	promyelocytic	JJ	JJ	_	11	amod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	APL	apl	NN	NN	_	5	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	line	line	NN	NN	_	11	compound	_	_
11	NB4	nb4	NN	NN	_	1	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	interferon	interferon	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	1	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IFN(alpha)	ifn(alpha)	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	as	as	RB	RB	_	14	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	IFN(beta)	ifn(beta)	NN	NN	_	14	conj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	gamma	gamma	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	14	punct	_	_
26	results	result	VBZ	VBZ	_	0	root	_	_
27	in	in	IN	IN	_	30	case	_	_
28	an	a	DT	DT	_	30	det	_	_
29	increased	increase	VBN	VBN	_	30	amod	_	_
30	expression	expression	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	transcripts	transcript	NNS	NNS	_	30	nmod	_	_
34	coding	code	VBG	VBG	_	33	acl	_	_
35	for	for	IN	IN	_	39	case	_	_
36	retinoic-acid	retinoic-acid	JJ	JJ	_	39	amod	_	_
37	receptor	receptor	NN	NN	_	39	compound	_	_
38	type	type	NN	NN	_	39	compound	_	_
39	alpha	alpha	NN	NN	_	34	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	RAR(alpha)	rar(alpha)	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	and	and	CC	CC	_	39	cc	_	_
44	the	the	DT	DT	_	49	det	_	_
45	leukemia-specific	leukemia-specific	JJ	JJ	_	49	amod	_	_
46	retinoic	retinoic	JJ	JJ	_	49	amod	_	_
47	acid	acid	NN	NN	_	49	compound	_	_
48	receptor	receptor	NN	NN	_	49	compound	_	_
49	PML-RAR	pml-rar	NN	NN	_	39	conj	_	_
50	.	.	.	.	_	26	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	RAR(alpha)	rar(alpha)	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	PML-RAR	pml-rar	NN	NN	_	5	conj	_	_
8	mRNAs	mrna	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	rapid	rapid	JJ	JJ	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	it	it	PRP	PRP	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	parallelled	parallel	VBN	VBN	_	10	conj	_	_
15	by	by	IN	IN	_	17	case	_	_
16	an	a	DT	DT	_	17	det	_	_
17	increase	increase	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	corresponding	corresponding	JJ	JJ	_	21	amod	_	_
21	proteins	protein	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Up-regulation	up-regulation	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	RAR(alpha)	rar(alpha)	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	PML-RAR	pml-rar	NN	NN	_	3	conj	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IFN(alpha)	ifn(alpha)	NN	NN	_	1	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	accompanied	accompany	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	strong	strong	JJ	JJ	_	15	amod	_	_
15	potentiation	potentiation	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	induction	induction	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	2	2	CD	CD	_	23	nummod	_	_
21	retinoid-dependent	retinoid-dependent	JJ	JJ	_	23	amod	_	_
22	granulocytic	granulocytic	JJ	JJ	_	23	amod	_	_
23	markers	marker	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	i.e.	i.e.	FW	FW	_	23	dep	_	_
26	,	,	,	,	_	23	punct	_	_
27	granulocyte-colony-stimulating	granulocyte-colony-stimulating	JJ	JJ	_	30	amod	_	_
28	factor	factor	NN	NN	_	30	compound	_	_
29	receptor	receptor	NN	NN	_	30	compound	_	_
30	mRNA	mrna	NN	NN	_	23	appos	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	leukocyte	leukocyte	NN	NN	_	34	compound	_	_
33	alkaline	alkaline	NN	NN	_	34	compound	_	_
34	phosphatase	phosphatase	NN	NN	_	30	conj	_	_
35	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	IFN(alpha)	ifn(alpha)	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	have	have	VB	VB	_	0	root	_	_
7	any	any	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	6	dobj	_	_
9	on	on	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	retinoid-dependent	retinoid-dependent	JJ	JJ	_	12	amod	_	_
12	regulation	regulation	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	markers	marker	NNS	NNS	_	12	nmod	_	_
18	CD11b	cd11b	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CD33	cd33	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IFN-dependent	ifn-dependent	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	22	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	RAR(alpha)	rar(alpha)	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	the	the	DT	DT	_	10	det	_	_
9	enhancing	enhancing	JJ	JJ	_	10	amod	_	_
10	effect	effect	NN	NN	_	3	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytokine	cytokine	NN	NN	_	10	nmod	_	_
14	on	on	IN	IN	_	18	case	_	_
15	retinoid-dependent	retinoid-dependent	JJ	JJ	_	18	amod	_	_
16	granulocytic	granulocytic	JJ	JJ	_	18	amod	_	_
17	markers	marker	NNS	NNS	_	18	compound	_	_
18	expression	expression	NN	NN	_	10	nmod	_	_
19	may	may	MD	MD	_	22	aux	_	_
20	be	be	VB	VB	_	22	cop	_	_
21	a	a	DT	DT	_	22	det	_	_
22	characteristic	characteristic	NN	NN	_	0	root	_	_
23	of	of	IN	IN	_	26	case	_	_
24	PML-RAR	pml-rar	NN	NN	_	25	nmod:npmod	_	_
25	positive	positive	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	22	punct	_	_
28	since	since	IN	IN	_	33	mark	_	_
29	the	the	DT	DT	_	30	det	_	_
30	phenomena	phenomenon	NNS	NNS	_	33	nsubjpass	_	_
31	are	be	VBP	VBP	_	33	auxpass	_	_
32	not	not	RB	RB	_	33	neg	_	_
33	observed	observe	VBN	VBN	_	22	advcl	_	_
34	in	in	IN	IN	_	36	case	_	_
35	HL-60	hl-60	NN	NN	_	36	compound	_	_
36	promyelocytes	promyelocyte	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	22	punct	_	_

1	Interferons	interferon	NNS	NNS	_	6	nsubj	_	_
2	as	as	RB	RB	_	1	cc	_	_
3	well	well	RB	RB	_	2	mwe	_	_
4	as	as	IN	IN	_	2	mwe	_	_
5	retinoids	retinoid	NNS	NNS	_	1	conj	_	_
6	inhibit	inhibit	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	growth	growth	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NB4	nb4	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	although	although	IN	IN	_	22	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	2	2	CD	CD	_	16	nummod	_	_
16	classes	class	NNS	NNS	_	22	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	compounds	compound	NNS	NNS	_	16	nmod	_	_
19	do	do	VBP	VBP	_	22	aux	_	_
20	not	not	RB	RB	_	22	neg	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	interact	interact	VBP	VBP	_	6	advcl	_	_
23	in	in	IN	IN	_	27	case	_	_
24	terms	term	NNS	NNS	_	27	dep	_	_
25	of	of	IN	IN	_	27	case	_	_
26	anti-proliferative	anti-proliferative	JJ	JJ	_	27	amod	_	_
27	activity	activity	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	possible	possible	JJ	JJ	_	6	amod	_	_
6	use	use	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	combinations	combination	NNS	NNS	_	6	nmod	_	_
9	between	between	IN	IN	_	10	case	_	_
10	IFNs	ifn	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
13	acid	acid	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cyto-differentiating	cyto-differentiating	JJ	JJ	_	17	amod	_	_
17	treatment	treatment	NN	NN	_	6	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	APL	apl	NN	NN	_	20	compound	_	_
20	patients	patient	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Susceptibility	susceptibility	NN	NN	_	20	nsubjpass	_	_
2	to	to	TO	TO	_	5	case	_	_
3	natural	natural	JJ	JJ	_	5	amod	_	_
4	killer	killer	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	down	down	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	1	conj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	MHC	mhc	NN	NN	_	13	compound	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	I	i	CD	CD	_	13	nummod	_	_
13	expression	expression	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	adenovirus	adenovirus	NN	NN	_	18	compound	_	_
16	12	12	CD	CD	_	18	nummod	_	_
17	transformed	transform	VBN	VBN	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	1	nmod	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	regulated	regulate	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	24	case	_	_
22	different	different	JJ	JJ	_	24	amod	_	_
23	E1A	e1a	NN	NN	_	24	compound	_	_
24	domains	domain	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	adenoviruses	adenovirus	NNS	NNS	_	4	nsubj	_	_
4	transform	transform	VBP	VBP	_	0	root	_	_
5	rodent	rodent	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	4	dobj	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vitro	vitro	FW	FW	_	4	advmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	but	but	CC	CC	_	4	cc	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	cells	cell	NNS	NNS	_	29	nsubj	_	_
13	transformed	transform	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	serotypes	serotype	NNS	NNS	_	13	nmod	_	_
16	belonging	belong	VBG	VBG	_	15	acl	_	_
17	to	to	TO	TO	_	18	case	_	_
18	subgroups	subgroup	NNS	NNS	_	16	nmod	_	_
19	A	a	NN	NN	_	18	dep	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Ad12	ad12	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	B	b	NN	NN	_	19	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Ad3	ad3	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	tumorigenic	tumorigenic	JJ	JJ	_	4	conj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	immunocompetent	immunocompetent	JJ	JJ	_	32	amod	_	_
32	animals	animal	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	MHC-class	mhc-class	NN	NN	_	10	compound	_	_
9	I	i	CD	CD	_	10	nummod	_	_
10	antigens	antigen	NNS	NNS	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	repressed	repress	VBN	VBN	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	might	might	MD	MD	_	15	aux	_	_
15	allow	allow	VB	VB	_	12	conj	_	_
16	them	they	PRP	PRP	_	18	nsubj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	escape	escape	VB	VB	_	15	ccomp	_	_
19	from	from	IN	IN	_	20	case	_	_
20	recognition	recognition	NN	NN	_	18	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	cytotoxic	cytotoxic	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CTL	ctl	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	develop	develop	VB	VB	_	18	conj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	tumor	tumor	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	5	det	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	6	nsubj	_	_
6	appear	appear	VBP	VBP	_	0	root	_	_
7	resistant	resistant	JJ	JJ	_	6	xcomp	_	_
8	to	to	TO	TO	_	9	case	_	_
9	lysis	lysis	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	16	case	_	_
11	natural	natural	JJ	JJ	_	12	amod	_	_
12	killer	killer	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NK	nk	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	17	dep	_	_
3	the	the	DT	DT	_	7	det	_	_
4	E1A	e1a	NN	NN	_	7	compound	_	_
5	domain	domain	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	s	s	NNS	NNS	_	2	dobj	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	responsible	responsible	JJ	JJ	_	7	amod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	properties	property	NNS	NNS	_	9	nmod	_	_
13	several	several	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	17	nsubjpass	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	created	create	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	26	mark	_	_
19	transforming	transform	VBG	VBG	_	26	amod	_	_
20	baby	baby	NN	NN	_	22	compound	_	_
21	rat	rat	NN	NN	_	22	compound	_	_
22	kidney	kidney	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	BRK	brk	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	cells	cell	NNS	NNS	_	17	advcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	set	set	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	plasmids	plasmid	NNS	NNS	_	29	nmod	_	_
32	expressing	express	VBG	VBG	_	31	acl	_	_
33	different	different	JJ	JJ	_	38	amod	_	_
34	Ad2/Ad12	ad2/ad12	NN	NN	_	38	compound	_	_
35	hybrid	hybrid	NN	NN	_	38	compound	_	_
36	E1A	e1a	NN	NN	_	38	compound	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	products	product	NNS	NNS	_	32	dobj	_	_
39	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	MHC	mhc	NN	NN	_	6	compound	_	_
3	class	class	NN	NN	_	6	compound	_	_
4	1	1	CD	CD	_	6	nummod	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	cells	cell	NNS	NNS	_	8	nmod	_	_
11	expressing	express	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	16	det	_	_
13	Ad12	ad12	NN	NN	_	16	compound	_	_
14	13S	13s	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	product	product	NN	NN	_	11	dobj	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	10	conj	_	_
20	transformed	transform	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	26	case	_	_
22	Ad2/Ad12	ad2/ad12	NN	NN	_	26	compound	_	_
23	hybrid	hybrid	NN	NN	_	26	compound	_	_
24	E1A	e1a	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	product	product	NN	NN	_	20	nmod	_	_
27	harboring	harbor	VBG	VBG	_	26	acl	_	_
28	the	the	DT	DT	_	30	det	_	_
29	C-terminal	c-terminal	JJ	JJ	_	30	amod	_	_
30	part	part	NN	NN	_	27	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	conserved	conserve	VBN	VBN	_	34	amod	_	_
34	region	region	NN	NN	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	CR	cr	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	3	3	CD	CD	_	34	nummod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	Ad12	ad12	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	8	punct	_	_

1	Susceptibility	susceptibility	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	these	these	DT	DT	_	6	det	_	_
4	transformed	transform	VBN	VBN	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	1	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	NK	nk	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	determined	determine	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	cytolytic	cytolytic	JJ	JJ	_	14	amod	_	_
14	assays	assay	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	obtained	obtain	VBD	VBD	_	2	acl	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	Ad12	ad12	NN	NN	_	9	compound	_	_
8	E1A	e1a	NN	NN	_	9	compound	_	_
9	domains	domain	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	4	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	11	xcomp	_	_
14	resistance	resistance	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	NK	nk	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	IL-2	il-2	NN	NN	_	4	compound	_	_
3	response	response	NN	NN	_	4	compound	_	_
4	element	element	NN	NN	_	16	nsubj	_	_
5	in	in	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	human	human	JJ	JJ	_	12	amod	_	_
8	IL-2	il-2	NN	NN	_	12	compound	_	_
9	receptor	receptor	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	chain	chain	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	composite	composite	JJ	JJ	_	16	amod	_	_
16	element	element	NN	NN	_	0	root	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	binds	bind	VBZ	VBZ	_	16	acl:relcl	_	_
19	Stat5	stat5	NN	NN	_	18	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	Elf-1	elf-1	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	HMG-I(Y)	hmg-i(y)	NN	NN	_	19	conj	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	a	a	DT	DT	_	28	det	_	_
26	GATA	gata	NN	NN	_	28	compound	_	_
27	family	family	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	19	conj	_	_
29	.	.	.	.	_	16	punct	_	_

1	Expression	expression	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	12	case	_	_
3	the	the	DT	DT	_	12	det	_	_
4	human	human	JJ	JJ	_	12	amod	_	_
5	interleukin-2	interleukin-2	NN	NN	_	12	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-2	il-2	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	receptor	receptor	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	chain	chain	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	1	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	potently	potently	RB	RB	_	15	advmod	_	_
15	upregulated	upregulate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	own	own	JJ	JJ	_	19	amod	_	_
19	ligand	ligand	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	IL-2	il-2	NN	NN	_	19	appos	_	_
22	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	characterize	characterize	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	12	det	_	_
8	essential	essential	JJ	JJ	_	12	amod	_	_
9	upstream	upstream	JJ	JJ	_	12	amod	_	_
10	IL-2	il-2	NN	NN	_	12	compound	_	_
11	response	response	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	6	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	contains	contain	VBZ	VBZ	_	12	acl:relcl	_	_
15	both	both	CC	CC	_	20	dep	_	_
16	consensus	consensus	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	non-consensus	non-consensus	JJ	JJ	_	15	conj	_	_
19	GAS	gas	NN	NN	_	20	compound	_	_
20	motifs	motif	NNS	NNS	_	14	dobj	_	_
21	,	,	,	,	_	12	punct	_	_
22	two	two	CD	CD	_	26	nummod	_	_
23	putative	putative	JJ	JJ	_	26	amod	_	_
24	Ets	ets	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	12	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	EBS	ebs	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	26	punct	_	_
31	one	one	CD	CD	_	34	nsubj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	which	which	WDT	WDT	_	31	nmod	_	_
34	overlaps	overlap	VBZ	VBZ	_	26	acl:relcl	_	_
35	the	the	DT	DT	_	38	det	_	_
36	consensus	consensus	NN	NN	_	38	compound	_	_
37	GAS	gas	NN	NN	_	38	compound	_	_
38	motif	motif	NN	NN	_	34	dobj	_	_
39	,	,	,	,	_	12	punct	_	_
40	and	and	CC	CC	_	12	cc	_	_
41	a	a	DT	DT	_	43	det	_	_
42	GATA	gata	NN	NN	_	43	compound	_	_
43	motif	motif	NN	NN	_	12	conj	_	_
44	,	,	,	,	_	43	punct	_	_
45	which	which	WDT	WDT	_	46	nsubj	_	_
46	overlaps	overlap	VBZ	VBZ	_	43	acl:relcl	_	_
47	the	the	DT	DT	_	50	det	_	_
48	non-consensus	non-consensus	JJ	JJ	_	50	amod	_	_
49	GAS	gas	NN	NN	_	50	compound	_	_
50	motif	motif	NN	NN	_	46	dobj	_	_
51	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	although	although	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	individual	individual	JJ	JJ	_	7	amod	_	_
7	components	component	NNS	NNS	_	13	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	element	element	NN	NN	_	7	nmod	_	_
11	do	do	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	respond	respond	VB	VB	_	19	advcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	IL-2	il-2	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	together	together	RB	RB	_	18	advmod	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	form	form	VBP	VBP	_	2	ccomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	composite	composite	JJ	JJ	_	22	amod	_	_
22	element	element	NN	NN	_	19	dobj	_	_
23	capable	capable	JJ	JJ	_	22	amod	_	_
24	of	of	IN	IN	_	25	mark	_	_
25	conferring	confer	VBG	VBG	_	23	advcl	_	_
26	IL-2	il-2	NN	NN	_	27	compound	_	_
27	responsiveness	responsiveness	NN	NN	_	25	dobj	_	_
28	to	to	TO	TO	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	heterologous	heterologous	JJ	JJ	_	31	amod	_	_
31	promoter	promoter	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Multiple	multiple	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	13	nsubj	_	_
3	including	include	VBG	VBG	_	4	case	_	_
4	Stat5	stat5	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	Elf-1	elf-1	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	HMG-I(Y)	hmg-i(y)	NN	NN	_	4	conj	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	GATA	gata	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	4	conj	_	_
13	bind	bind	VBP	VBP	_	0	root	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	IL-2	il-2	NN	NN	_	18	compound	_	_
17	response	response	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	mutation	mutation	NN	NN	_	28	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	any	any	DT	DT	_	23	det	_	_
23	one	one	CD	CD	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	these	these	DT	DT	_	27	det	_	_
26	binding	bind	VBG	VBG	_	27	amod	_	_
27	sites	site	NNS	NNS	_	23	nmod	_	_
28	diminishes	diminish	VBZ	VBZ	_	13	conj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	activity	activity	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	element	element	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	13	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	unidentified	unidentified	JJ	JJ	_	5	amod	_	_
3	Ets	ets	NN	NN	_	5	compound	_	_
4	family	family	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	EBS	ebs	NN	NN	_	6	nmod	_	_
10	overlapping	overlap	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	consensus	consensus	NN	NN	_	14	compound	_	_
13	GAS	gas	NN	NN	_	14	compound	_	_
14	motif	motif	NN	NN	_	10	dobj	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	appears	appear	VBZ	VBZ	_	6	conj	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	negatively	negatively	RB	RB	_	19	advmod	_	_
19	regulate	regulate	VB	VB	_	16	xcomp	_	_
20	the	the	DT	DT	_	24	det	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	IL-2R	il-2r	NN	NN	_	24	compound	_	_
23	alpha	alpha	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	19	dobj	_	_
25	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	IL-2-induced	il-2-induced	JJ	JJ	_	7	amod	_	_
4	IL-2R	il-2r	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	8	nsubj	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	complex	complex	JJ	JJ	_	12	amod	_	_
11	upstream	upstream	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	appears	appear	VBZ	VBZ	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	contain	contain	VB	VB	_	15	xcomp	_	_
18	binding	bind	VBG	VBG	_	19	amod	_	_
19	sites	site	NNS	NNS	_	17	dobj	_	_
20	for	for	IN	IN	_	26	case	_	_
21	both	both	CC	CC	_	22	cc:preconj	_	_
22	positive	positive	JJ	JJ	_	26	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	negative	negative	JJ	JJ	_	22	conj	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	factors	factor	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	7	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cAMP-dependent	camp-dependent	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	2	conj	_	_
7	activities	activity	NNS	NNS	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	CD40-activated	cd40-activated	JJ	JJ	_	12	amod	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	7	advmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	7	nsubj	_	_
7	undergo	undergo	VBP	VBP	_	0	root	_	_
8	long-term	long-term	JJ	JJ	_	9	amod	_	_
9	proliferation	proliferation	NN	NN	_	7	dobj	_	_
10	when	when	WRB	WRB	_	11	advmod	_	_
11	activated	activate	VBN	VBN	_	7	advcl	_	_
12	through	through	IN	IN	_	13	case	_	_
13	CD40	cd40	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	protein	protein	NN	NN	_	13	appos	_	_
17	expressed	express	VBN	VBN	_	16	acl	_	_
18	on	on	IN	IN	_	21	case	_	_
19	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	surface	surface	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	nature	nature	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CD40-dependent	cd40-dependent	JJ	JJ	_	5	amod	_	_
5	signals	signal	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	13	case	_	_
7	proliferating	proliferate	VBG	VBG	_	13	amod	_	_
8	fresh	fresh	JJ	JJ	_	13	amod	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
11	virus-negative	virus-negative	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	currently	currently	RB	RB	_	16	advmod	_	_
16	unknown	unknown	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	a	a	DT	DT	_	10	det	_	_
6	CD40-dependent	cd40-dependent	JJ	JJ	_	10	amod	_	_
7	B	b	NN	NN	_	10	compound	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	culture	culture	NN	NN	_	10	compound	_	_
10	system	system	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	examine	examine	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	role	role	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	different	different	JJ	JJ	_	21	amod	_	_
19	signal	signal	NN	NN	_	21	compound	_	_
20	transduction	transduction	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PKC	pkc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	depletion	depletion	NN	NN	_	17	nsubj	_	_
8	generated	generate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	16	case	_	_
10	a	a	DT	DT	_	16	det	_	_
11	long-term	long-term	JJ	JJ	_	16	amod	_	_
12	phorbol	phorbol	NN	NN	_	16	compound	_	_
13	12	12	CD	CD	_	16	nummod	_	_
14	myristate	myristate	NN	NN	_	16	compound	_	_
15	13-acetate	13-acetate	NN	NN	_	16	compound	_	_
16	treatment	treatment	NN	NN	_	8	nmod	_	_
17	had	have	VBD	VBD	_	0	root	_	_
18	weak	weak	JJ	JJ	_	19	amod	_	_
19	effects	effect	NNS	NNS	_	17	dobj	_	_
20	on	on	IN	IN	_	21	case	_	_
21	proliferation	proliferation	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	Rather	rather	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	auxpass	_	_
9	directly	directly	RB	RB	_	10	advmod	_	_
10	involved	involve	VBN	VBN	_	6	xcomp	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	mediating	mediate	VBG	VBG	_	10	advcl	_	_
13	CD40-dependent	cd40-dependent	JJ	JJ	_	14	amod	_	_
14	signals	signal	NNS	NNS	_	12	dobj	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	use	use	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	14	case	_	_
4	the	the	DT	DT	_	14	det	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	11	nmod:npmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PTK	ptk	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	-specific	-specific	JJ	JJ	_	14	amod	_	_
12	inhibitor	inhibitor	NN	NN	_	14	compound	_	_
13	herbimycin	herbimycin	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	2	nmod	_	_
15	dramatically	dramatically	RB	RB	_	16	advmod	_	_
16	decreased	decrease	VBD	VBD	_	0	root	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	proliferation	proliferation	NN	NN	_	16	dobj	_	_
19	without	without	IN	IN	_	20	mark	_	_
20	altering	alter	VBG	VBG	_	16	advcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	human	human	JJ	JJ	_	30	amod	_	_
26	immunodeficiency	immunodeficiency	NN	NN	_	30	compound	_	_
27	virus-1	virus-1	NN	NN	_	30	compound	_	_
28	long	long	JJ	JJ	_	30	amod	_	_
29	terminal	terminal	JJ	JJ	_	30	amod	_	_
30	repeat	repeat	NN	NN	_	22	nmod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	HIV-1	hiv-1	NN	NN	_	33	compound	_	_
33	LTR	ltr	NN	NN	_	30	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	30	punct	_	_
36	a	a	DT	DT	_	37	det	_	_
37	promoter	promoter	NN	NN	_	30	appos	_	_
38	largely	largely	RB	RB	_	39	advmod	_	_
39	dependent	dependent	JJ	JJ	_	37	amod	_	_
40	on	on	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	binding	binding	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	47	case	_	_
44	nuclear	nuclear	JJ	JJ	_	47	amod	_	_
45	factor	factor	NN	NN	_	47	compound	_	_
46	kappa	kappa	NN	NN	_	47	compound	_	_
47	B	b	NN	NN	_	42	nmod	_	_
48	(	(	-LRB-	-LRB-	_	50	punct	_	_
49	NF-kappa	nf-kappa	NN	NN	_	50	compound	_	_
50	B	b	NN	NN	_	47	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	10	det	_	_
5	cAMP-dependent	camp-dependent	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	nmod:npmod	_	_
8	specific	specific	JJ	JJ	_	10	amod	_	_
9	inhibitor	inhibitor	NN	NN	_	10	compound	_	_
10	H-89	h-89	NN	NN	_	12	nsubj	_	_
11	totally	totally	RB	RB	_	12	advmod	_	_
12	inhibited	inhibit	VBD	VBD	_	0	root	_	_
13	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
14	LTR	ltr	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	concentration	concentration	NN	NN	_	12	nmod	_	_
19	as	as	RB	RB	_	22	advmod	_	_
20	low	low	JJ	JJ	_	22	advmod	_	_
21	as	as	IN	IN	_	22	advmod	_	_
22	100	100	CD	CD	_	23	nummod	_	_
23	nM	nm	NN	NN	_	18	dep	_	_
24	without	without	IN	IN	_	25	mark	_	_
25	affecting	affect	VBG	VBG	_	12	advcl	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	proliferation	proliferation	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	12	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	26	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSA	emsa	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	supershift	supershift	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	4	conj	_	_
11	using	use	VBG	VBG	_	4	acl	_	_
12	an	a	DT	DT	_	16	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	11	dobj	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	kappa	kappa	NN	NN	_	21	compound	_	_
20	light	light	JJ	JJ	_	21	amod	_	_
21	chain	chain	NN	NN	_	16	nmod	_	_
22	as	as	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	probe	probe	NN	NN	_	11	nmod	_	_
25	,	,	,	,	_	26	punct	_	_
26	revealed	reveal	VBD	VBD	_	0	root	_	_
27	that	that	IN	IN	_	36	mark	_	_
28	both	both	CC	CC	_	29	cc:preconj	_	_
29	p65	p65	NNS	NNS	_	36	nsubj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	RelA	rela	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	c-Rel	c-rel	NN	NN	_	29	conj	_	_
35	were	be	VBD	VBD	_	36	cop	_	_
36	present	present	JJ	JJ	_	26	ccomp	_	_
37	in	in	IN	IN	_	40	case	_	_
38	CD40-stimulated	cd40-stimulated	JJ	JJ	_	40	amod	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	26	punct	_	_

1	While	while	IN	IN	_	6	mark	_	_
2	PKC	pkc	NN	NN	_	3	compound	_	_
3	depletion	depletion	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	alter	alter	VB	VB	_	21	advcl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	level	level	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	21	punct	_	_
12	treatment	treatment	NN	NN	_	21	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	H-89	h-89	NN	NN	_	12	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	herbimycin	herbimycin	NN	NN	_	20	compound	_	_
20	A	a	NN	NN	_	17	conj	_	_
21	provoked	provoke	VBD	VBD	_	0	root	_	_
22	a	a	DT	DT	_	23	det	_	_
23	decrease	decrease	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	level	level	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	importance	importance	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	different	different	JJ	JJ	_	10	amod	_	_
8	signal	signal	NN	NN	_	10	compound	_	_
9	transducing	transducing	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	5	nmod	_	_
11	leading	lead	VBG	VBG	_	10	acl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	CD40	cd40	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Active	active	JJ	JJ	_	2	amod	_	_
2	suppression	suppression	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	class	class	NN	NN	_	9	compound	_	_
6	II	ii	CD	CD	_	9	nummod	_	_
7	transactivator-encoding	transactivator-encoding	JJ	JJ	_	9	amod	_	_
8	AIR-1	air-1	NN	NN	_	9	compound	_	_
9	locus	locus	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsible	responsible	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	lack	lack	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	major	major	JJ	JJ	_	22	amod	_	_
17	histocompatibility	histocompatibility	NN	NN	_	22	compound	_	_
18	complex	complex	NN	NN	_	22	compound	_	_
19	class	class	NN	NN	_	22	compound	_	_
20	II	ii	CD	CD	_	22	nummod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	14	nmod	_	_
23	observed	observe	VBN	VBN	_	22	acl	_	_
24	during	during	IN	IN	_	25	case	_	_
25	differentiation	differentiation	NN	NN	_	23	nmod	_	_
26	from	from	IN	IN	_	28	case	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	to	to	TO	TO	_	31	case	_	_
30	plasma	plasma	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	29	nmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	genetic	genetic	JJ	JJ	_	6	amod	_	_
6	control	control	NN	NN	_	29	nsubjpass	_	_
7	of	of	IN	IN	_	17	case	_	_
8	major	major	JJ	JJ	_	10	amod	_	_
9	histocompatibility	histocompatibility	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	17	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MHC	mhc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	class	class	NN	NN	_	17	compound	_	_
15	II	ii	CD	CD	_	17	nummod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	6	nmod	_	_
18	during	during	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	transition	transition	NN	NN	_	17	nmod	_	_
21	from	from	IN	IN	_	23	case	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cell	cell	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	plasma	plasma	NN	NN	_	26	compound	_	_
26	cell	cell	NN	NN	_	20	nmod	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	analyzed	analyze	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	Class	class	NN	NN	_	3	compound	_	_
2	II	ii	CD	CD	_	3	nummod	_	_
3	molecules	molecule	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	plasma	plasma	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	because	because	IN	IN	_	14	case	_	_
11	of	of	IN	IN	_	10	mwe	_	_
12	an	a	DT	DT	_	14	det	_	_
13	active	active	JJ	JJ	_	14	amod	_	_
14	suppression	suppression	NN	NN	_	6	nmod	_	_
15	resulting	result	VBG	VBG	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	abrogation	abrogation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	class	class	NN	NN	_	23	compound	_	_
21	II	ii	CD	CD	_	23	nummod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	23	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	plasma	plasma	NN	NN	_	7	nmod:npmod	_	_
7	cell-specific	cell-specific	JJ	JJ	_	9	amod	_	_
8	repressor	repressor	NN	NN	_	9	compound	_	_
9	function	function	NN	NN	_	23	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	designated	designate	VBN	VBN	_	9	acl	_	_
12	SIR	sir	NN	NN	_	11	xcomp	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	suppressor	suppressor	NN	NN	_	12	dep	_	_
15	of	of	IN	IN	_	18	case	_	_
16	immune	immune	JJ	JJ	_	18	amod	_	_
17	response	response	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	14	nmod	_	_
19	)	)	-RRB-	-RRB-	_	14	punct	_	_
20	,	,	,	,	_	9	punct	_	_
21	does	do	VBZ	VBZ	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	act	act	VB	VB	_	2	ccomp	_	_
24	directly	directly	RB	RB	_	23	advmod	_	_
25	on	on	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	transcription	transcription	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	class	class	NN	NN	_	31	compound	_	_
30	II	ii	CD	CD	_	31	nummod	_	_
31	genes	gene	NNS	NNS	_	27	nmod	_	_
32	,	,	,	,	_	27	punct	_	_
33	but	but	CC	CC	_	27	cc	_	_
34	instead	instead	RB	RB	_	27	conj	_	_
35	on	on	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	transcription	transcription	NN	NN	_	27	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	AIR-1	air-1	NN	NN	_	41	compound	_	_
41	gene	gene	NN	NN	_	37	nmod	_	_
42	,	,	,	,	_	41	punct	_	_
43	whose	whose	WP$	WP$	_	44	nmod:poss	_	_
44	product	product	NN	NN	_	55	nsubj	_	_
45	,	,	,	,	_	44	punct	_	_
46	the	the	DT	DT	_	49	det	_	_
47	class	class	NN	NN	_	49	compound	_	_
48	II	ii	CD	CD	_	49	nummod	_	_
49	transactivator	transactivator	NN	NN	_	44	appos	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	CIITA	ciita	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	,	,	,	,	_	44	punct	_	_
54	is	be	VBZ	VBZ	_	55	cop	_	_
55	fundamental	fundamental	JJ	JJ	_	41	acl:relcl	_	_
56	for	for	IN	IN	_	58	case	_	_
57	the	the	DT	DT	_	58	det	_	_
58	regulation	regulation	NN	NN	_	55	nmod	_	_
59	of	of	IN	IN	_	64	case	_	_
60	the	the	DT	DT	_	64	det	_	_
61	constitutive	constitutive	JJ	JJ	_	64	amod	_	_
62	and	and	CC	CC	_	61	cc	_	_
63	inducible	inducible	JJ	JJ	_	61	conj	_	_
64	expression	expression	NN	NN	_	58	nmod	_	_
65	of	of	IN	IN	_	69	case	_	_
66	MHC	mhc	NN	NN	_	69	compound	_	_
67	class	class	NN	NN	_	69	compound	_	_
68	II	ii	CD	CD	_	69	nummod	_	_
69	genes	gene	NNS	NNS	_	64	nmod	_	_
70	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	unambiguously	unambiguously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	fact	fact	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	24	mark	_	_
9	plasmacytoma	plasmacytoma	NN	NN	_	10	compound	_	_
10	x	x	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	10	dep	_	_
13	hybrids	hybrid	NNS	NNS	_	24	nsubj	_	_
14	carrying	carry	VBG	VBG	_	13	acl	_	_
15	an	a	DT	DT	_	17	det	_	_
16	AIR-1	air-1	NN	NN	_	17	compound	_	_
17	locus	locus	NN	NN	_	14	dobj	_	_
18	derived	derive	VBN	VBN	_	17	acl	_	_
19	from	from	IN	IN	_	21	case	_	_
20	CIITA-expressing	ciita-expressing	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	do	do	VBP	VBP	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	express	express	VB	VB	_	7	ccomp	_	_
25	CIITA-specific	ciita-specific	JJ	JJ	_	26	amod	_	_
26	transcripts	transcript	NNS	NNS	_	24	dobj	_	_
27	.	.	.	.	_	4	punct	_	_

1	Transfection	transfection	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	cDNA	cdna	NN	NN	_	1	nmod	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	10	det	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	CIITA	ciita	NN	NN	_	10	compound	_	_
9	coding	coding	NN	NN	_	10	compound	_	_
10	sequence	sequence	NN	NN	_	5	dobj	_	_
11	under	under	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	control	control	NN	NN	_	1	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	restores	restore	VBZ	VBZ	_	0	root	_	_
19	expression	expression	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	MHC	mhc	NN	NN	_	25	compound	_	_
23	class	class	NN	NN	_	25	compound	_	_
24	II	ii	CD	CD	_	25	nummod	_	_
25	genes	gene	NNS	NNS	_	19	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	hybrids	hybrid	NNS	NNS	_	19	nmod	_	_
29	and	and	CC	CC	_	18	cc	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	responsible	responsible	JJ	JJ	_	18	conj	_	_
32	for	for	IN	IN	_	35	case	_	_
33	de	de	FW	FW	_	35	amod	_	_
34	novo	novo	FW	FW	_	33	dep	_	_
35	expression	expression	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	41	case	_	_
37	mouse	mouse	NN	NN	_	41	compound	_	_
38	MHC	mhc	NN	NN	_	41	compound	_	_
39	class	class	NN	NN	_	41	compound	_	_
40	II	ii	CD	CD	_	41	nummod	_	_
41	genes	gene	NNS	NNS	_	35	nmod	_	_
42	in	in	IN	IN	_	48	case	_	_
43	both	both	CC	CC	_	48	cc:preconj	_	_
44	the	the	DT	DT	_	48	det	_	_
45	mouse	mouse	NN	NN	_	48	compound	_	_
46	plasmacytoma	plasmacytoma	NN	NN	_	48	compound	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	line	line	NN	NN	_	35	nmod	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	the	the	DT	DT	_	51	det	_	_
51	hybrids	hybrid	NNS	NNS	_	48	conj	_	_
52	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	confirm	confirm	VBP	VBP	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	extend	extend	VBP	VBP	_	3	conj	_	_
6	the	the	DT	DT	_	7	det	_	_
7	notion	notion	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	conservation	conservation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	AIR-1	air-1	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	product	product	NN	NN	_	11	nmod	_	_
17	across	across	IN	IN	_	19	case	_	_
18	species	species	NNS	NNS	_	19	compound	_	_
19	barriers	barrier	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	CIITA-transfected	ciita-transfected	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	hybrids	hybrid	NNS	NNS	_	18	nmod	_	_
7	,	,	,	,	_	18	punct	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	18	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	HLA-DQ	hla-dq	NN	NN	_	15	compound	_	_
15	heterodimer	heterodimer	NN	NN	_	10	nmod	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	observed	observe	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	attributable	attributable	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	lack	lack	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	HLA-DQ	hla-dq	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	14	compound	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	-DQ	-dq	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	10	conj	_	_
14	transcription	transcription	NN	NN	_	7	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	because	because	IN	IN	_	20	mark	_	_
17	both	both	DT	DT	_	18	det	_	_
18	transcripts	transcript	NNS	NNS	_	20	nsubj	_	_
19	were	be	VBD	VBD	_	20	cop	_	_
20	present	present	JJ	JJ	_	5	advcl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	CIITA-transfected	ciita-transfected	JJ	JJ	_	24	amod	_	_
24	hybrids	hybrid	NNS	NNS	_	20	nmod	_	_
25	,	,	,	,	_	20	punct	_	_
26	although	although	IN	IN	_	29	mark	_	_
27	at	at	IN	IN	_	29	case	_	_
28	reduced	reduce	VBN	VBN	_	29	amod	_	_
29	levels	level	NNS	NNS	_	20	advcl	_	_
30	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	support	support	VBP	VBP	_	0	root	_	_
5	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
6	previous	previous	JJ	JJ	_	7	amod	_	_
7	observations	observation	NNS	NNS	_	4	dobj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	expression	expression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	HLA-DQ	hla-dq	NN	NN	_	20	compound	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	subset	subset	NN	NN	_	13	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	which	which	WDT	WDT	_	26	nsubjpass	_	_
23	may	may	MD	MD	_	26	aux	_	_
24	be	be	VB	VB	_	26	auxpass	_	_
25	thus	thus	RB	RB	_	26	advmod	_	_
26	controlled	control	VBN	VBN	_	13	acl:relcl	_	_
27	at	at	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	posttranscriptional	posttranscriptional	JJ	JJ	_	30	amod	_	_
30	level	level	NN	NN	_	26	nmod	_	_
31	by	by	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	CIITA-independent	ciita-independent	JJ	JJ	_	34	amod	_	_
34	mechanism	mechanism	NN	NN	_	26	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	Chromosome	chromosome	NN	NN	_	3	compound	_	_
2	1	1	CD	CD	_	3	nummod	_	_
3	aneusomy	aneusomy	NN	NN	_	8	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	1p36	1p36	NN	NN	_	6	compound	_	_
6	under-representation	under-representation	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	related	related	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	histologic	histologic	JJ	JJ	_	11	amod	_	_
11	grade	grade	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	aneuploidy	aneuploidy	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	high	high	JJ	JJ	_	18	amod	_	_
17	c-erb	c-erb	NN	NN	_	18	compound	_	_
18	B-2	b-2	NN	NN	_	11	conj	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	loss	loss	NN	NN	_	11	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	bcl-2	bcl-2	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	ductal	ductal	JJ	JJ	_	27	amod	_	_
26	breast	breast	NN	NN	_	27	compound	_	_
27	carcinoma	carcinoma	NN	NN	_	11	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Chromosome	chromosome	NN	NN	_	3	compound	_	_
2	1	1	CD	CD	_	3	nummod	_	_
3	abnormalities	abnormality	NNS	NNS	_	10	nsubjpass	_	_
4	with	with	IN	IN	_	5	case	_	_
5	loss	loss	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	1p36	1p36	NN	NN	_	5	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	investigated	investigate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	95	95	CD	CD	_	14	nummod	_	_
13	breast-cancer	breast-cancer	NN	NN	_	14	compound	_	_
14	samples	sample	NNS	NNS	_	10	nmod	_	_
15	by	by	IN	IN	_	26	case	_	_
16	means	means	NNS	NNS	_	26	dep	_	_
17	of	of	IN	IN	_	26	case	_	_
18	a	a	DT	DT	_	26	det	_	_
19	dual-target	dual-target	JJ	JJ	_	26	amod	_	_
20	fluorescence	fluorescence	NN	NN	_	22	compound	_	_
21	in-situ	in-situ	FW	FW	_	22	compound	_	_
22	hybridization	hybridization	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	FISH	fish	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	technique	technique	NN	NN	_	10	nmod	_	_
27	using	use	VBG	VBG	_	26	acl	_	_
28	the	the	DT	DT	_	33	det	_	_
29	pUC	puc	NN	NN	_	33	compound	_	_
30	1.77	1.77	CD	CD	_	29	nummod	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	p1-79	p1-79	NN	NN	_	29	conj	_	_
33	probes	probe	NNS	NNS	_	27	dobj	_	_
34	,	,	,	,	_	33	punct	_	_
35	specific	specific	JJ	JJ	_	33	amod	_	_
36	for	for	IN	IN	_	41	case	_	_
37	the	the	DT	DT	_	41	det	_	_
38	1q12	1q12	NN	NN	_	41	compound	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	1p36	1p36	NN	NN	_	38	conj	_	_
41	regions	region	NNS	NNS	_	35	nmod	_	_
42	,	,	,	,	_	35	punct	_	_
43	respectively	respectively	RB	RB	_	35	advmod	_	_
44	.	.	.	.	_	10	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	8	nsubjpass	_	_
2	for	for	IN	IN	_	3	case	_	_
3	one	one	CD	CD	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	both	both	DT	DT	_	6	det	_	_
6	probes	probe	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	83/95	83/95	CD	CD	_	11	nummod	_	_
11	samples	sample	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	Relative	relative	JJ	JJ	_	3	amod	_	_
2	1p36	1p36	NN	NN	_	3	compound	_	_
3	under-representation	under-representation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	79/95	79/95	CD	CD	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	relevance	relevance	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	alterations	alteration	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	studied	study	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	comparing	compare	VBG	VBG	_	8	advcl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	FISH	fish	NN	NN	_	13	compound	_	_
13	results	result	NNS	NNS	_	10	dobj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	several	several	JJ	JJ	_	16	amod	_	_
16	parameters	parameter	NNS	NNS	_	10	nmod	_	_
17	currently	currently	RB	RB	_	18	advmod	_	_
18	used	use	VBN	VBN	_	16	acl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	breast-cancer	breast-cancer	JJ	JJ	_	21	amod	_	_
21	pathology	pathology	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Distinct	distinct	JJ	JJ	_	2	amod	_	_
2	patterns	pattern	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	chromosome	chromosome	NN	NN	_	6	compound	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	abnormalities	abnormality	NNS	NNS	_	2	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	among	among	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	histologic	histologic	JJ	JJ	_	12	amod	_	_
12	types	type	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	breast	breast	NN	NN	_	15	compound	_	_
15	carcinoma	carcinoma	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Lobular	lobular	JJ	JJ	_	4	amod	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	mucinous	mucinous	JJ	JJ	_	1	conj	_	_
4	samples	sample	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	few	few	JJ	JJ	_	9	nummod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	no	no	DT	DT	_	6	conj	_	_
9	alterations	alteration	NNS	NNS	_	5	dobj	_	_
10	,	,	,	,	_	5	punct	_	_
11	whereas	whereas	IN	IN	_	5	dep	_	_
12	most	most	JJS	JJS	_	14	amod	_	_
13	ductal	ductal	JJ	JJ	_	14	amod	_	_
14	samples	sample	NNS	NNS	_	15	nsubj	_	_
15	had	have	VBD	VBD	_	5	parataxis	_	_
16	high	high	JJ	JJ	_	19	amod	_	_
17	chromosome	chromosome	NN	NN	_	19	compound	_	_
18	1	1	CD	CD	_	19	nummod	_	_
19	polysomy	polysomy	NN	NN	_	15	dobj	_	_
20	with	with	IN	IN	_	21	case	_	_
21	under-representation	under-representation	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	1p36	1p36	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	ductal	ductal	JJ	JJ	_	3	amod	_	_
3	carcinomas	carcinoma	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	chromosome	chromosome	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	alterations	alteration	NNS	NNS	_	8	nsubj	_	_
8	increased	increase	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	histologic	histologic	JJ	JJ	_	11	amod	_	_
11	grade	grade	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	aneuploidy	aneuploidy	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	loss	loss	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	bcl-2	bcl-2	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	high	high	JJ	JJ	_	23	amod	_	_
21	c-erb	c-erb	NN	NN	_	23	compound	_	_
22	B-2	b-2	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	11	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	associations	association	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	statistically	statistically	RB	RB	_	8	advmod	_	_
8	significant	significant	JJ	JJ	_	4	xcomp	_	_
9	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlation	correlation	NN	NN	_	29	nsubjpass	_	_
3	between	between	IN	IN	_	6	case	_	_
4	chromosome	chromosome	NN	NN	_	6	compound	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	alterations	alteration	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	grade	grade	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	9	punct	_	_
11	age	age	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	size	size	NN	NN	_	9	appos	_	_
14	,	,	,	,	_	9	punct	_	_
15	lymph-node	lymph-node	JJ	JJ	_	16	amod	_	_
16	involvement	involvement	NN	NN	_	9	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	hormonal	hormonal	JJ	JJ	_	20	amod	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	presence	presence	NN	NN	_	9	conj	_	_
21	,	,	,	,	_	9	punct	_	_
22	proliferation	proliferation	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	9	conj	_	_
24	or	or	CC	CC	_	9	cc	_	_
25	p53	p53	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	9	conj	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	detected	detect	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	utility	utility	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	FISH	fish	NN	NN	_	9	compound	_	_
9	technique	technique	NN	NN	_	5	nmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	better	better	JJR	JJR	_	13	amod	_	_
13	definition	definition	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	biological	biological	JJ	JJ	_	17	amod	_	_
17	characteristics	characteristic	NNS	NNS	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	ductal	ductal	JJ	JJ	_	20	amod	_	_
20	carcinomas	carcinoma	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Silencing	silencing	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	fetal	fetal	JJ	JJ	_	6	amod	_	_
5	globin	globin	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	1	nmod	_	_
7	is	be	VBZ	VBZ	_	8	aux	_	_
8	impaired	impaired	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	19	case	_	_
10	the	the	DT	DT	_	19	dep	_	_
11	absence	absence	NN	NN	_	19	dep	_	_
12	of	of	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	adult	adult	JJ	JJ	_	19	amod	_	_
15	beta-globin	beta-globin	IN	IN	_	19	amod	_	_
16	gene	gene	NN	NN	_	19	compound	_	_
17	activator	activator	NN	NN	_	19	compound	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	EKLF	eklf	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Globin	globin	NN	NN	_	2	compound	_	_
2	genes	gene	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	subject	subject	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	10	case	_	_
6	tissue-specific	tissue-specific	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	developmental	developmental	JJ	JJ	_	9	amod	_	_
9	stage-specific	stage-specific	JJ	JJ	_	6	conj	_	_
10	regulation	regulation	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	switch	switch	NN	NN	_	16	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	fetal	fetal	JJ	JJ	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	gamma	gamma	NN	NN	_	5	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	-to	-to	TO	TO	_	10	case	_	_
10	adult	adult	JJ	JJ	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	beta	beta	NN	NN	_	10	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-globin	-globin	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	2	dep	_	_
16	occurs	occur	VBZ	VBZ	_	0	root	_	_
17	within	within	IN	IN	_	20	case	_	_
18	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
19	precursor	precursor	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	adult	adult	JJ	JJ	_	24	amod	_	_
24	lineage	lineage	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Previously	previously	RB	RB	_	5	advmod	_	_
2	we	we	PRP	PRP	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	others	other	NNS	NNS	_	2	conj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	targeted	target	VBN	VBN	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	disruption	disruption	NN	NN	_	5	nmod	_	_
10	that	that	IN	IN	_	24	mark	_	_
11	the	the	DT	DT	_	14	det	_	_
12	zinc	zinc	NN	NN	_	14	compound	_	_
13	finger	finger	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	24	nsubjpass	_	_
15	,	,	,	,	_	14	punct	_	_
16	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
17	Kruppel-like	kruppel-like	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	14	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	EKLF	eklf	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	14	punct	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	5	ccomp	_	_
25	for	for	IN	IN	_	26	case	_	_
26	expression	expression	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	beta-globin	beta-globin	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	mice	mouse	NNS	NNS	_	26	nmod	_	_
33	,	,	,	,	_	24	punct	_	_
34	presumably	presumably	RB	RB	_	36	advmod	_	_
35	through	through	IN	IN	_	36	case	_	_
36	interaction	interaction	NN	NN	_	24	nmod	_	_
37	with	with	IN	IN	_	41	case	_	_
38	a	a	DT	DT	_	41	det	_	_
39	high-affinity	high-affinity	JJ	JJ	_	41	amod	_	_
40	binding	bind	VBG	VBG	_	41	amod	_	_
41	site	site	NN	NN	_	36	nmod	_	_
42	in	in	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	proximal	proximal	JJ	JJ	_	45	amod	_	_
45	promoter	promoter	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	17	dep	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	EKLF	eklf	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	developmental	developmental	JJ	JJ	_	10	amod	_	_
10	regulation	regulation	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	gamma-globin	gamma-globin	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	interbred	interbreed	VBD	VBD	_	0	root	_	_
18	EKLF	eklf	NN	NN	_	19	compound	_	_
19	heterozygotes	heterozygote	NNS	NNS	_	17	dobj	_	_
20	(	(	-LRB-	-LRB-	_	19	punct	_	_
21	+/-	+/-	CC	CC	_	19	cc	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	with	with	IN	IN	_	24	case	_	_
24	mice	mouse	NNS	NNS	_	17	nmod	_	_
25	harboring	harbor	VBG	VBG	_	24	acl	_	_
26	a	a	DT	DT	_	32	det	_	_
27	human	human	JJ	JJ	_	32	amod	_	_
28	beta-globin	beta-globin	NN	NN	_	32	compound	_	_
29	yeast	yeast	NN	NN	_	32	compound	_	_
30	artificial	artificial	JJ	JJ	_	32	amod	_	_
31	chromosome	chromosome	NN	NN	_	32	compound	_	_
32	transgene	transgene	NN	NN	_	25	dobj	_	_
33	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	21	mark	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	dep	_	_
6	absence	absence	NN	NN	_	8	dep	_	_
7	of	of	IN	IN	_	8	case	_	_
8	EKLF	eklf	NN	NN	_	21	nmod	_	_
9	,	,	,	,	_	21	punct	_	_
10	while	while	IN	IN	_	16	mark	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	beta-globin	beta-globin	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	16	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	dramatically	dramatically	RB	RB	_	16	advmod	_	_
16	reduced	reduce	VBN	VBN	_	21	advcl	_	_
17	,	,	,	,	_	21	punct	_	_
18	gamma-globin	gamma-globin	NN	NN	_	19	compound	_	_
19	transcripts	transcript	NNS	NNS	_	21	nsubj	_	_
20	are	be	VBP	VBP	_	21	aux	_	_
21	elevated	elevated	JJ	JJ	_	2	ccomp	_	_
22	approximately	approximately	RB	RB	_	23	advmod	_	_
23	5-fold	5-fold	RB	RB	_	21	advmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Impaired	impaired	JJ	JJ	_	2	amod	_	_
2	silencing	silencing	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gamma-globin	gamma-globin	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	identifies	identify	VBZ	VBZ	_	0	root	_	_
7	EKLF	eklf	NN	NN	_	6	dobj	_	_
8	as	as	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	first	first	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	6	nmod	_	_
13	participating	participate	VBG	VBG	_	12	acl	_	_
14	quantitatively	quantitatively	RB	RB	_	13	advmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	gamma-globin	gamma-globin	NN	NN	_	20	compound	_	_
18	to	to	TO	TO	_	17	dep	_	_
19	beta-globin	beta-globin	NN	NN	_	17	dep	_	_
20	switch	switch	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	compatible	compatible	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	competitive	competitive	JJ	JJ	_	8	amod	_	_
8	model	model	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	switching	switching	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	14	nmod	_	_
13	EKLF	eklf	NN	NN	_	14	nsubj	_	_
14	mediates	mediate	VBZ	VBZ	_	8	acl:relcl	_	_
15	an	a	DT	DT	_	18	det	_	_
16	adult	adult	JJ	JJ	_	18	amod	_	_
17	stage-specific	stage-specific	JJ	JJ	_	18	amod	_	_
18	interaction	interaction	NN	NN	_	14	dobj	_	_
19	between	between	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	beta-globin	beta-globin	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	28	det	_	_
26	locus	locus	NN	NN	_	28	compound	_	_
27	control	control	NN	NN	_	28	compound	_	_
28	region	region	NN	NN	_	23	conj	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	excludes	exclude	VBZ	VBZ	_	28	acl:relcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	gamma-globin	gamma-globin	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	4	punct	_	_

1	Modulatory	modulatory	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	catecholamines	catecholamine	NNS	NNS	_	4	conj	_	_
7	on	on	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	interleukin-12	interleukin-12	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	interleukin-10	interleukin-10	NN	NN	_	9	conj	_	_
12	production	production	NN	NN	_	2	nmod	_	_
13	:	:	:	:	_	2	punct	_	_
14	clinical	clinical	JJ	JJ	_	15	amod	_	_
15	implications	implication	NNS	NNS	_	2	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	Interleukin-12	interleukin-12	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-12	il-12	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	key	key	JJ	JJ	_	8	amod	_	_
8	inducer	inducer	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	differentiation	differentiation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	18	case	_	_
12	uncommitted	uncommitted	JJ	JJ	_	18	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	helper	helper	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TH	th	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	toward	toward	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	TH1	th1	NN	NN	_	22	compound	_	_
22	phenotype	phenotype	NN	NN	_	10	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	regulates	regulate	VBZ	VBZ	_	22	acl:relcl	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	immunity	immunity	NN	NN	_	25	dobj	_	_
28	,	,	,	,	_	8	punct	_	_
29	whereas	whereas	IN	IN	_	8	dep	_	_
30	IL-10	il-10	NN	NN	_	31	nsubj	_	_
31	inhibits	inhibit	VBZ	VBZ	_	8	parataxis	_	_
32	TH1	th1	NN	NN	_	33	compound	_	_
33	functions	function	NNS	NNS	_	31	dobj	_	_
34	and	and	CC	CC	_	31	cc	_	_
35	potentiates	potentiate	VBZ	VBZ	_	31	conj	_	_
36	TH2-regulated	th2-regulated	JJ	JJ	_	37	amod	_	_
37	responses	response	NNS	NNS	_	35	dobj	_	_
38	(	(	-LRB-	-LRB-	_	42	punct	_	_
39	i.e.	i.e.	FW	FW	_	42	compound	_	_
40	,	,	,	,	_	42	punct	_	_
41	humoral	humoral	JJ	JJ	_	42	amod	_	_
42	immunity	immunity	NN	NN	_	37	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	stress	stress	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	TH1/TH2	th1/th2	NN	NN	_	10	compound	_	_
10	balance	balance	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	studied	study	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	ability	ability	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	three	three	CD	CD	_	20	nummod	_	_
18	prototype	prototype	NN	NN	_	20	compound	_	_
19	stress	stress	NN	NN	_	20	compound	_	_
20	hormones	hormone	NNS	NNS	_	15	nmod	_	_
21	-	-	:	:	_	20	punct	_	_
22	dexamethasone	dexamethasone	NN	NN	_	20	dep	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	a	a	DT	DT	_	26	det	_	_
25	synthetic	synthetic	JJ	JJ	_	26	amod	_	_
26	glucocorticoid	glucocorticoid	NN	NN	_	22	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	catecholamines	catecholamine	NNS	NNS	_	22	conj	_	_
31	norepinephrine	norepinephrine	NN	NN	_	30	dep	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	epinephrine	epinephrine	NN	NN	_	31	conj	_	_
34	-	-	:	:	_	20	punct	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	alter	alter	VB	VB	_	15	acl	_	_
37	the	the	DT	DT	_	38	det	_	_
38	production	production	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	IL-12	il-12	NN	NN	_	38	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	p70	p70	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	IL-10	il-10	NN	NN	_	40	conj	_	_
46	induced	induce	VBN	VBN	_	38	acl	_	_
47	by	by	IN	IN	_	49	case	_	_
48	bacterial	bacterial	JJ	JJ	_	49	amod	_	_
49	lipopolysaccharide	lipopolysaccharide	NN	NN	_	46	nmod	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	LPS	lps	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	in	in	IN	IN	_	56	case	_	_
54	human	human	JJ	JJ	_	56	amod	_	_
55	whole	whole	JJ	JJ	_	56	amod	_	_
56	blood	blood	NN	NN	_	49	nmod	_	_
57	.	.	.	.	_	13	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	LPS-induced	lps-induced	JJ	JJ	_	6	amod	_	_
4	bioactive	bioactive	JJ	JJ	_	6	amod	_	_
5	IL-12	il-12	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dose-dependent	dose-dependent	JJ	JJ	_	10	amod	_	_
10	fashion	fashion	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	at	at	IN	IN	_	15	case	_	_
13	physiologically	physiologically	RB	RB	_	14	advmod	_	_
14	relevant	relevant	JJ	JJ	_	15	amod	_	_
15	concentrations	concentration	NNS	NNS	_	10	conj	_	_
16	;	;	:	:	_	2	punct	_	_
17	it	it	PRP	PRP	_	18	nsubj	_	_
18	had	have	VBD	VBD	_	2	parataxis	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	IL-10	il-10	NN	NN	_	23	compound	_	_
23	secretion	secretion	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	3	amod	_	_
3	reduction	reduction	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	IL-12	il-12	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	antagonized	antagonize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	RU	ru	NN	NN	_	8	nmod	_	_
11	486	486	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	10	punct	_	_
13	a	a	DT	DT	_	15	det	_	_
14	glucocorticoid-receptor	glucocorticoid-receptor	JJ	JJ	_	15	amod	_	_
15	antagonist	antagonist	NN	NN	_	10	appos	_	_
16	,	,	,	,	_	8	punct	_	_
17	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	17	ccomp	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Norepinephrine	norepinephrine	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	epinephrine	epinephrine	NN	NN	_	1	conj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	suppressed	suppress	VBD	VBD	_	0	root	_	_
6	IL-12	il-12	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	dose-dependent	dose-dependent	JJ	JJ	_	11	amod	_	_
11	fashion	fashion	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	at	at	IN	IN	_	15	case	_	_
14	physiological	physiological	JJ	JJ	_	15	amod	_	_
15	concentrations	concentration	NNS	NNS	_	11	conj	_	_
16	;	;	:	:	_	5	punct	_	_
17	both	both	DT	DT	_	18	det	_	_
18	catecholamines	catecholamine	NNS	NNS	_	23	nsubj	_	_
19	,	,	,	,	_	23	punct	_	_
20	however	however	RB	RB	_	23	advmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	dose-dependently	dose-dependently	RB	RB	_	23	advmod	_	_
23	increased	increase	VBD	VBD	_	5	parataxis	_	_
24	the	the	DT	DT	_	25	det	_	_
25	production	production	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	IL-10	il-10	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	either	either	DT	DT	_	5	det	_	_
5	catecholamine	catecholamine	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	10	case	_	_
7	IL-12	il-12	NN	NN	_	10	compound	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	secretion	secretion	NN	NN	_	2	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	blocked	block	VBN	VBN	_	0	root	_	_
13	completely	completely	RB	RB	_	12	advmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	propranolol	propranolol	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	19	det	_	_
18	beta-adrenoreceptor	beta-adrenoreceptor	JJ	JJ	_	19	amod	_	_
19	antagonist	antagonist	NN	NN	_	15	appos	_	_
20	,	,	,	,	_	12	punct	_	_
21	indicating	indicate	VBG	VBG	_	12	xcomp	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	they	they	PRP	PRP	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	mediated	mediate	VBN	VBN	_	21	ccomp	_	_
26	by	by	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	beta-adrenergic	beta-adrenergic	JJ	JJ	_	29	amod	_	_
29	receptor	receptor	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	central	central	JJ	JJ	_	8	amod	_	_
7	nervous	nervous	JJ	JJ	_	8	amod	_	_
8	system	system	NN	NN	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	regulate	regulate	VB	VB	_	3	ccomp	_	_
11	IL-12	il-12	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-10	il-10	NN	NN	_	11	conj	_	_
14	secretion	secretion	NN	NN	_	10	dobj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	,	,	,	,	_	10	punct	_	_
17	hence	hence	RB	RB	_	10	advmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	TH1/TH2	th1/th2	NN	NN	_	20	nsubj	_	_
20	balance	balance	NN	NN	_	10	dep	_	_
21	via	via	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
24	end-effectors	end-effector	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	stress	stress	NN	NN	_	28	compound	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	stress	stress	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	cause	cause	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	selective	selective	JJ	JJ	_	8	amod	_	_
8	suppression	suppression	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	TH1	th1	NN	NN	_	11	compound	_	_
11	functions	function	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	a	a	DT	DT	_	14	det	_	_
14	shift	shift	NN	NN	_	8	conj	_	_
15	toward	toward	IN	IN	_	24	case	_	_
16	a	a	DT	DT	_	24	det	_	_
17	TH2	th2	NN	NN	_	19	compound	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	pattern	pattern	NN	NN	_	24	compound	_	_
20	rather	rather	RB	RB	_	19	cc	_	_
21	than	than	IN	IN	_	20	mwe	_	_
22	generalized	generalized	JJ	JJ	_	19	amod	_	_
23	TH	th	NN	NN	_	24	compound	_	_
24	suppression	suppression	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TH1-to-TH2	th1-to-th2	JJ	JJ	_	3	amod	_	_
3	shift	shift	NN	NN	_	6	nsubj	_	_
4	may	may	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	responsible	responsible	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	stress-induced	stress-induced	JJ	JJ	_	10	amod	_	_
10	susceptibility	susceptibility	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	organism	organism	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	certain	certain	JJ	JJ	_	16	amod	_	_
16	infections	infection	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Through	through	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	same	same	JJ	JJ	_	21	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	a	a	DT	DT	_	6	det	_	_
6	reciprocal	reciprocal	JJ	JJ	_	3	conj	_	_
7	mechanism	mechanism	NN	NN	_	3	dep	_	_
8	,	,	,	,	_	21	punct	_	_
9	states	state	NNS	NNS	_	21	nsubj	_	_
10	associated	associate	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	chronic	chronic	JJ	JJ	_	13	amod	_	_
13	hyperactivity	hyperactivity	NN	NN	_	10	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	hypoactivity	hypoactivity	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	stress	stress	NN	NN	_	19	compound	_	_
19	system	system	NN	NN	_	13	nmod	_	_
20	might	might	MD	MD	_	21	aux	_	_
21	influence	influence	VB	VB	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	susceptibility	susceptibility	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	an	a	DT	DT	_	26	det	_	_
26	individual	individual	NN	NN	_	23	nmod	_	_
27	to	to	TO	TO	_	37	case	_	_
28	certain	certain	JJ	JJ	_	37	amod	_	_
29	autoimmune	autoimmune	JJ	JJ	_	37	amod	_	_
30	,	,	,	,	_	29	punct	_	_
31	allergic	allergic	JJ	JJ	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	infectious	infectious	JJ	JJ	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	or	or	CC	CC	_	29	cc	_	_
36	neoplastic	neoplastic	JJ	JJ	_	29	conj	_	_
37	diseases	disease	NNS	NNS	_	23	nmod	_	_
38	.	.	.	.	_	21	punct	_	_

1	Nasal	nasal	JJ	JJ	_	5	amod	_	_
2	NK-	nk-	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	T-cell	t-cell	NN	NN	_	2	conj	_	_
5	lymphomas	lymphoma	NNS	NNS	_	6	nsubj	_	_
6	share	share	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	same	same	JJ	JJ	_	9	amod	_	_
9	type	type	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	Epstein-Barr	epstein-barr	JJ	JJ	_	13	amod	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	latency	latency	NN	NN	_	9	nmod	_	_
14	as	as	IN	IN	_	16	case	_	_
15	nasopharyngeal	nasopharyngeal	JJ	JJ	_	16	amod	_	_
16	carcinoma	carcinoma	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Hodgkin	hodgkin	NN	NN	_	20	nmod:poss	_	_
19	's	's	POS	POS	_	18	case	_	_
20	disease	disease	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	6	punct	_	_

1	Nasal	nasal	JJ	JJ	_	3	amod	_	_
2	T/NK-cell	t/nk-cell	JJ	JJ	_	3	amod	_	_
3	lymphomas	lymphoma	NNS	NNS	_	7	nsubjpass	_	_
4	can	can	MD	MD	_	7	aux	_	_
5	be	be	VB	VB	_	7	auxpass	_	_
6	further	further	RBR	RBR	_	7	advmod	_	_
7	separated	separate	VBN	VBN	_	0	root	_	_
8	into	into	IN	IN	_	9	case	_	_
9	those	those	DT	DT	_	7	nmod	_	_
10	of	of	IN	IN	_	17	case	_	_
11	natural	natural	JJ	JJ	_	12	amod	_	_
12	killer	killer	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NK	nk	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lineage	lineage	NN	NN	_	9	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	of	of	IN	IN	_	21	case	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	lineage	lineage	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	9	punct	_	_
23	with	with	IN	IN	_	24	case	_	_
24	differences	difference	NNS	NNS	_	9	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cellular	cellular	JJ	JJ	_	27	amod	_	_
27	phenotype	phenotype	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	T-cell	t-cell	NN	NN	_	30	compound	_	_
30	receptor	receptor	NN	NN	_	35	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	TcR	tcr	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	rearrangement	rearrangement	NN	NN	_	27	conj	_	_
36	and	and	CC	CC	_	27	cc	_	_
37	TcR	tcr	NN	NN	_	39	compound	_	_
38	transcript	transcript	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	27	conj	_	_
40	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	NK-	nk-	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	T-cell	t-cell	NN	NN	_	2	conj	_	_
5	subtypes	subtype	NNS	NNS	_	8	nsubjpass	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	closely	closely	RB	RB	_	8	advmod	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
11	virus	virus	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	EBV	ebv	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	EBV	ebv	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	determined	determine	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	23	23	CD	CD	_	12	nummod	_	_
12	cases	case	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	nasal	nasal	JJ	JJ	_	15	amod	_	_
15	lymphoma	lymphoma	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	NL	nl	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	by	by	IN	IN	_	22	case	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	situ	situ	FW	FW	_	20	dep	_	_
22	hybridisation	hybridisation	NN	NN	_	9	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	ISH	ish	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	22	punct	_	_
27	reverse	reverse	JJ	JJ	_	30	amod	_	_
28	transcriptase-polymerase	transcriptase-polymerase	NN	NN	_	30	compound	_	_
29	chain	chain	NN	NN	_	30	compound	_	_
30	reaction	reaction	NN	NN	_	22	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	RT-PCR	rt-pcr	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	22	cc	_	_
35	immunohistochemistry	immunohistochemistry	NN	NN	_	22	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	IH	ih	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	9	punct	_	_

1	Of	of	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	23	23	CD	CD	_	4	nummod	_	_
4	cases	case	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	19	19	CD	CD	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	classified	classify	VBN	VBN	_	0	root	_	_
9	as	as	IN	IN	_	10	case	_	_
10	NK-cell	nk-cell	NN	NN	_	8	advcl	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	4	4	CD	CD	_	8	conj	_	_
13	as	as	IN	IN	_	15	case	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	tumours	tumour	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	8	punct	_	_

1	ISH	ish	NN	NN	_	7	nsubj	_	_
2	for	for	IN	IN	_	6	case	_	_
3	EBV-encoded	ebv-encoded	JJ	JJ	_	6	amod	_	_
4	small	small	JJ	JJ	_	6	amod	_	_
5	non-polyadenylated	non-polyadenylated	JJ	JJ	_	6	amod	_	_
6	RNAs	rna	NNS	NNS	_	1	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	all	all	DT	DT	_	10	det	_	_
10	cases	case	NNS	NNS	_	17	nsubj	_	_
11	,	,	,	,	_	17	punct	_	_
12	whether	whether	IN	IN	_	13	mark	_	_
13	NK	nk	NN	NN	_	17	dep	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	17	punct	_	_
17	harboured	harbour	VBD	VBD	_	7	ccomp	_	_
18	EBV	ebv	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	virtually	virtually	RB	RB	_	21	advmod	_	_
21	all	all	DT	DT	_	23	amod	_	_
22	tumour	tumour	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	RT-PCR	rt-pcr	NN	NN	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	NL	nl	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	DT	DT	_	7	det	_	_
7	subtypes	subtype	NNS	NNS	_	4	nmod	_	_
8	expressed	express	VBD	VBD	_	2	ccomp	_	_
9	EBNAI	ebnai	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	QUK	quk	NN	NN	_	14	compound	_	_
13	splice	splice	NN	NN	_	14	compound	_	_
14	pattern	pattern	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	latent	latent	JJ	JJ	_	19	amod	_	_
18	membrane	membrane	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	14	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	LMP1	lmp1	NN	NN	_	19	appos	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	2	2	CD	CD	_	21	conj	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	the	the	DT	DT	_	29	det	_	_
26	BamHI	bamhi	NN	NN	_	29	compound	_	_
27	A	a	NN	NN	_	29	compound	_	_
28	rightward	rightward	JJ	JJ	_	29	amod	_	_
29	transcripts	transcript	NNS	NNS	_	14	conj	_	_
30	in	in	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	dep	_	_
32	absence	absence	NN	NN	_	35	dep	_	_
33	of	of	IN	IN	_	35	case	_	_
34	EBNA2	ebna2	NN	NN	_	35	compound	_	_
35	mRNAs	mrna	NNS	NNS	_	8	nmod	_	_
36	,	,	,	,	_	8	punct	_	_
37	compatible	compatible	JJ	JJ	_	8	xcomp	_	_
38	with	with	IN	IN	_	43	case	_	_
39	the	the	DT	DT	_	43	det	_	_
40	latency	latency	NN	NN	_	43	compound	_	_
41	type	type	NN	NN	_	43	compound	_	_
42	II	ii	CD	CD	_	43	nummod	_	_
43	pattern	pattern	NN	NN	_	37	nmod	_	_
44	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	analysis	analysis	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	EBV	ebv	NN	NN	_	8	compound	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IH	ih	NN	NN	_	8	nmod	_	_
11	revealed	reveal	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	heterogeneous	heterogeneous	JJ	JJ	_	14	amod	_	_
14	pattern	pattern	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	EBV	ebv	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	nmod	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	single-cell	single-cell	NN	NN	_	22	compound	_	_
22	level	level	NN	NN	_	18	nmod	_	_
23	consisting	consist	VBG	VBG	_	22	acl	_	_
24	of	of	IN	IN	_	30	case	_	_
25	both	both	CC	CC	_	26	cc:preconj	_	_
26	LMP1+	lmp1+	JJ	JJ	_	30	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	LMP1-	lmp1-	JJ	JJ	_	26	conj	_	_
29	tumour	tumour	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	23	nmod	_	_
31	,	,	,	,	_	11	punct	_	_
32	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
33	a	a	DT	DT	_	34	det	_	_
34	mixture	mixture	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	latency	latency	NN	NN	_	34	nmod	_	_
37	I	i	CD	CD	_	36	dep	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	II	ii	CD	CD	_	37	conj	_	_
40	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	2	2	CD	CD	_	5	nummod	_	_
3	early	early	JJ	JJ	_	5	amod	_	_
4	lytic	lytic	JJ	JJ	_	5	amod	_	_
5	transcripts	transcript	NNS	NNS	_	13	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	BZLF1	bzlf1	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	BHRF1	bhrf1	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	detected	detect	VBN	VBN	_	30	advcl	_	_
14	in	in	IN	IN	_	18	case	_	_
15	13	13	CD	CD	_	18	nummod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	10	10	CD	CD	_	15	conj	_	_
18	cases	case	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	respectively	respectively	RB	RB	_	18	advmod	_	_
21	,	,	,	,	_	30	punct	_	_
22	the	the	DT	DT	_	23	det	_	_
23	lack	lack	NN	NN	_	30	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	ZEBRA	zebra	NN	NN	_	26	compound	_	_
26	staining	staining	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	any	any	DT	DT	_	29	det	_	_
29	case	case	NN	NN	_	23	nmod	_	_
30	indicates	indicate	VBZ	VBZ	_	0	root	_	_
31	that	that	IN	IN	_	38	mark	_	_
32	these	these	DT	DT	_	34	det	_	_
33	lytic	lytic	JJ	JJ	_	34	amod	_	_
34	transcripts	transcript	NNS	NNS	_	38	nsubjpass	_	_
35	are	be	VBP	VBP	_	38	auxpass	_	_
36	most	most	RBS	RBS	_	37	advmod	_	_
37	likely	likely	RB	RB	_	38	advmod	_	_
38	expressed	express	VBN	VBN	_	30	ccomp	_	_
39	by	by	IN	IN	_	41	case	_	_
40	rare	rare	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	38	nmod	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	biopsies	biopsy	NNS	NNS	_	41	nmod	_	_
45	entering	enter	VBG	VBG	_	44	acl	_	_
46	lytic	lytic	JJ	JJ	_	47	amod	_	_
47	cycle	cycle	NN	NN	_	45	dobj	_	_
48	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	viral	viral	JJ	JJ	_	4	amod	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	pattern	pattern	NN	NN	_	15	nsubj	_	_
5	similar	similar	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	that	that	DT	DT	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	nasopharyngeal	nasopharyngeal	JJ	JJ	_	10	amod	_	_
10	carcinoma	carcinoma	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Hodgkin	hodgkin	NN	NN	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	disease	disease	NN	NN	_	10	conj	_	_
15	suggests	suggest	VBZ	VBZ	_	0	root	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	EBV	ebv	NN	NN	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	exploit	exploit	VB	VB	_	15	ccomp	_	_
20	common	common	JJ	JJ	_	22	amod	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	mechanisms	mechanism	NNS	NNS	_	19	dobj	_	_
23	for	for	IN	IN	_	25	case	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	30	case	_	_
27	diverse	diverse	JJ	JJ	_	30	amod	_	_
28	host	host	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	types	type	NNS	NNS	_	22	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	Down-regulation	down-regulation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	immunogenic	immunogenic	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EBNA2-EBNA6	ebna2-ebna6	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	nasal	nasal	JJ	JJ	_	10	amod	_	_
10	lymphoma	lymphoma	NN	NN	_	1	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	enable	enable	VB	VB	_	0	root	_	_
13	tumour	tumour	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	12	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	evade	evade	VB	VB	_	12	xcomp	_	_
17	host	host	NN	NN	_	20	compound	_	_
18	cytotoxic	cytotoxic	JJ	JJ	_	20	amod	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	surveillance	surveillance	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	12	punct	_	_

1	Presence	presence	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	variant	variant	JJ	JJ	_	5	amod	_	_
5	form	form	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	estrogen	estrogen	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	1	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	normal	normal	JJ	JJ	_	17	amod	_	_
17	individuals	individual	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	lupus	lupus	NN	NN	_	20	compound	_	_
20	patients	patient	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	Estrogen	estrogen	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	participate	participate	VB	VB	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	pathogenesis	pathogenesis	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	systemic	systemic	JJ	JJ	_	10	amod	_	_
9	lupus	lupus	NN	NN	_	10	compound	_	_
10	erythematosus	erythematosus	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SLE	sle	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	via	via	IN	IN	_	17	case	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
17	receptor	receptor	NN	NN	_	3	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	various	various	JJ	JJ	_	7	amod	_	_
7	isoforms	isoform	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	estrogen	estrogen	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	ER	er	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	SLE	sle	NN	NN	_	4	nmod	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	isolated	isolate	VBD	VBD	_	2	parataxis	_	_
19	RNA	rna	NN	NN	_	18	dobj	_	_
20	from	from	IN	IN	_	22	case	_	_
21	mononuclear	mononuclear	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	lupus	lupus	NN	NN	_	25	compound	_	_
25	patients	patient	NNS	NNS	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	controls	control	NNS	NNS	_	25	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	RT-PCR	rt-pcr	NN	NN	_	1	dobj	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	1	parataxis	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	identify	identify	VB	VB	_	5	xcomp	_	_
8	both	both	CC	CC	_	13	cc:preconj	_	_
9	the	the	DT	DT	_	13	det	_	_
10	full	full	JJ	JJ	_	13	amod	_	_
11	length	length	NN	NN	_	13	compound	_	_
12	wild-type	wild-type	JJ	JJ	_	13	amod	_	_
13	form	form	NN	NN	_	7	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	an	a	DT	DT	_	16	det	_	_
16	isoform	isoform	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ER	er	NN	NN	_	16	nmod	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	precisely	precisely	RB	RB	_	22	advmod	_	_
22	lacks	lack	VBZ	VBZ	_	16	acl:relcl	_	_
23	exon	exon	NN	NN	_	24	compound	_	_
24	V	v	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	patient	patient	NN	NN	_	22	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	normal	normal	JJ	JJ	_	30	amod	_	_
30	individuals	individual	NNS	NNS	_	27	conj	_	_
31	.	.	.	.	_	1	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	although	although	IN	IN	_	5	mark	_	_
5	limited	limited	JJ	JJ	_	7	dep	_	_
6	,	,	,	,	_	7	punct	_	_
7	suggest	suggest	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	individuals	individual	NNS	NNS	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	express	express	VB	VB	_	7	ccomp	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	wild-type	wild-type	JJ	JJ	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	truncated	truncate	VBN	VBN	_	15	conj	_	_
18	version	version	NN	NN	_	15	dep	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	same	same	JJ	JJ	_	22	amod	_	_
22	time	time	NN	NN	_	12	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	whereas	whereas	IN	IN	_	28	mark	_	_
25	lupus	lupus	NN	NN	_	26	compound	_	_
26	patients	patient	NNS	NNS	_	28	nsubj	_	_
27	only	only	RB	RB	_	28	advmod	_	_
28	express	express	VBP	VBP	_	12	advcl	_	_
29	either	either	CC	CC	_	31	cc:preconj	_	_
30	the	the	DT	DT	_	31	det	_	_
31	wild-type	wild-type	JJ	JJ	_	28	dobj	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	the	the	DT	DT	_	31	conj	_	_
34	truncated	truncate	VBN	VBN	_	33	amod	_	_
35	ER	er	NN	NN	_	31	dep	_	_
36	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	lead	lead	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	better	better	JJR	JJR	_	8	amod	_	_
8	understanding	understanding	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	reasons	reason	NNS	NNS	_	8	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	prevalence	prevalence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	lupus	lupus	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	females	female	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	estrogenic	estrogenic	JJ	JJ	_	23	amod	_	_
23	effects	effect	NNS	NNS	_	11	conj	_	_
24	on	on	IN	IN	_	27	case	_	_
25	SLE	sle	NN	NN	_	27	compound	_	_
26	disease	disease	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Lack	lack	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-12	il-12	NN	NN	_	4	compound	_	_
4	signaling	signaling	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	allergen-specific	allergen-specific	JJ	JJ	_	9	amod	_	_
8	Th2	th2	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	IL-12	il-12	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	powerful	powerful	JJ	JJ	_	5	amod	_	_
5	skewer	skewer	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	CD4+	cd4+	JJ	JJ	_	10	amod	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	5	nmod	_	_
11	toward	toward	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Th1	th1	NN	NN	_	14	compound	_	_
14	phenotype	phenotype	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	inducing	induce	VBG	VBG	_	5	advcl	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	naive	naive	JJ	JJ	_	22	amod	_	_
21	Th	th	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	addressed	address	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	question	question	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	mark	_	_
10	whether	whether	IN	IN	_	13	mark	_	_
11	IL-12	il-12	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	reverse	reverse	VB	VB	_	8	acl	_	_
14	established	established	JJ	JJ	_	16	amod	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	responses	response	NNS	NNS	_	13	dobj	_	_
17	into	into	IN	IN	_	19	case	_	_
18	Th1/Th0	th1/th0	NN	NN	_	19	compound	_	_
19	responses	response	NNS	NNS	_	13	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	inducing	induce	VBG	VBG	_	13	advcl	_	_
22	IFN-gamma	ifn-gamma	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	memory	memory	NN	NN	_	27	compound	_	_
26	Th2	th2	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	aim	aim	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	allergen-specific	allergen-specific	JJ	JJ	_	9	amod	_	_
6	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	14	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TCC	tcc	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	generated	generate	VBN	VBN	_	0	root	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
18	blood	blood	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	three	three	CD	CD	_	22	nummod	_	_
21	atopic	atopic	JJ	JJ	_	22	amod	_	_
22	patients	patient	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	cytokine	cytokine	NN	NN	_	27	compound	_	_
27	profiles	profile	NNS	NNS	_	29	nsubjpass	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	analyzed	analyze	VBN	VBN	_	14	conj	_	_
30	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	majority	majority	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	TCC	tcc	NN	NN	_	2	nmod	_	_
6	exhibited	exhibit	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	12	det	_	_
8	strongly	strongly	RB	RB	_	9	advmod	_	_
9	polarized	polarize	VBN	VBN	_	12	amod	_	_
10	Th2	th2	NN	NN	_	12	compound	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	profile	profile	NN	NN	_	6	dobj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	production	production	NN	NN	_	22	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	16	nmod	_	_
19	could	could	MD	MD	_	22	aux	_	_
20	not	not	RB	RB	_	22	neg	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	induced	induce	VBN	VBN	_	6	conj	_	_
23	by	by	IN	IN	_	25	case	_	_
24	exogenous	exogenous	JJ	JJ	_	25	amod	_	_
25	IL-12	il-12	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	those	those	DT	DT	_	3	det	_	_
3	TCC	tcc	NN	NN	_	13	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	low	low	JJ	JJ	_	7	amod	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	dep	_	_
10	absence	absence	NN	NN	_	12	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-12	il-12	NN	NN	_	7	nmod	_	_
13	responded	respond	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	IL-12	il-12	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	additional	additional	JJ	JJ	_	18	amod	_	_
18	enhancement	enhancement	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-12	il-12	NN	NN	_	3	compound	_	_
3	nonresponsiveness	nonresponsiveness	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Th2	th2	NN	NN	_	7	compound	_	_
7	clones	clone	NNS	NNS	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	further	further	RBR	RBR	_	10	advmod	_	_
10	evident	evident	JJ	JJ	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	total	total	JJ	JJ	_	14	amod	_	_
14	lack	lack	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IL-12-induced	il-12-induced	JJ	JJ	_	17	amod	_	_
17	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	STAT4	stat4	NN	NN	_	17	nmod	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	signal	signal	NN	NN	_	22	compound	_	_
22	transducer	transducer	NN	NN	_	19	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	activator	activator	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	transcription-4	transcription-4	NN	NN	_	22	nmod	_	_
27	)	)	-RRB-	-RRB-	_	22	punct	_	_
28	,	,	,	,	_	19	punct	_	_
29	a	a	DT	DT	_	31	det	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factor	factor	NN	NN	_	19	appos	_	_
32	that	that	WDT	WDT	_	35	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	35	auxpass	_	_
34	typically	typically	RB	RB	_	35	advmod	_	_
35	involved	involve	VBN	VBN	_	31	acl:relcl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	IL-12	il-12	NN	NN	_	38	compound	_	_
38	signaling	signaling	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Consequently	consequently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	IL-12	il-12	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	induce	induce	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	STAT4-containing	stat4-containing	JJ	JJ	_	13	amod	_	_
13	complexes	complex	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	these	these	DT	DT	_	20	det	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	clones	clone	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	TCC	tcc	NN	NN	_	3	nsubj	_	_
3	expressed	express	VBD	VBD	_	0	root	_	_
4	equal	equal	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	low-affinity	low-affinity	JJ	JJ	_	11	amod	_	_
9	IL-12R	il-12r	NN	NN	_	11	compound	_	_
10	beta1	beta1	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	allergen-specific	allergen-specific	JJ	JJ	_	8	amod	_	_
7	Th	th	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	17	nsubj	_	_
9	with	with	IN	IN	_	14	case	_	_
10	strongly	strongly	RB	RB	_	11	advmod	_	_
11	polarized	polarize	VBN	VBN	_	14	amod	_	_
12	Th2	th2	NN	NN	_	14	compound	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	profiles	profile	NNS	NNS	_	8	nmod	_	_
15	do	do	VBP	VBP	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	respond	respond	VB	VB	_	3	ccomp	_	_
18	to	to	TO	TO	_	19	case	_	_
19	IL-12	il-12	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	,	,	,	,	_	17	punct	_	_
22	therefore	therefore	RB	RB	_	17	advmod	_	_
23	,	,	,	,	_	17	punct	_	_
24	can	can	MD	MD	_	27	aux	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	induced	induce	VBN	VBN	_	17	dep	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	produce	produce	VB	VB	_	27	xcomp	_	_
30	IFN-gamma	ifn-gamma	NN	NN	_	29	dobj	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	apparent	apparent	JJ	JJ	_	4	amod	_	_
3	high	high	JJ	JJ	_	4	amod	_	_
4	frequency	frequency	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-12-nonresponsive	il-12-nonresponsive	JJ	JJ	_	8	amod	_	_
7	Th	th	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	within	within	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	allergen-specific	allergen-specific	JJ	JJ	_	12	amod	_	_
12	populations	population	NNS	NNS	_	4	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	atopic	atopic	JJ	JJ	_	15	amod	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	predicts	predict	VBZ	VBZ	_	0	root	_	_
17	a	a	DT	DT	_	20	det	_	_
18	limited	limited	JJ	JJ	_	20	amod	_	_
19	skewing	skewing	JJ	JJ	_	20	amod	_	_
20	potential	potential	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IL-12	il-12	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	case	case	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	established	established	JJ	JJ	_	29	amod	_	_
28	Th2	th2	NN	NN	_	29	compound	_	_
29	responses	response	NNS	NNS	_	25	nmod	_	_
30	,	,	,	,	_	16	punct	_	_
31	but	but	CC	CC	_	16	cc	_	_
32	only	only	RB	RB	_	33	advmod	_	_
33	affecting	affect	VBG	VBG	_	16	conj	_	_
34	newly	newly	RB	RB	_	35	advmod	_	_
35	recruited	recruit	VBN	VBN	_	38	amod	_	_
36	naive	naive	JJ	JJ	_	38	amod	_	_
37	Th	th	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	33	dobj	_	_
39	.	.	.	.	_	16	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	CD43/leukosialin-mediated	cd43/leukosialin-mediated	JJ	JJ	_	5	amod	_	_
5	pathway	pathway	NN	NN	_	1	nmod	_	_
6	for	for	IN	IN	_	7	mark	_	_
7	inducing	induce	VBG	VBG	_	5	acl	_	_
8	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	T-lymphoblastoid	t-lymphoblastoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	monoclonal	monoclonal	JJ	JJ	_	3	amod	_	_
3	antibody	antibody	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	mAb	mab	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	J393	j393	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	apoptosis	apoptosis	NN	NN	_	8	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Jurkat	jurkat	NN	NN	_	12	compound	_	_
12	T-cells	t-cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	NH2-terminal	nh2-terminal	JJ	JJ	_	5	amod	_	_
2	amino	amino	NN	NN	_	5	compound	_	_
3	acid	acid	NN	NN	_	5	compound	_	_
4	sequence	sequence	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	140-kDa	140-kda	JJ	JJ	_	10	amod	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	antigen	antigen	NN	NN	_	6	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	mAb	mab	NN	NN	_	13	compound	_	_
13	J393	j393	NN	NN	_	10	nmod	_	_
14	as	as	IN	IN	_	15	case	_	_
15	CD43/leukosialin	cd43/leukosialin	NN	NN	_	6	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	major	major	JJ	JJ	_	19	amod	_	_
19	sialoglycoprotein	sialoglycoprotein	NN	NN	_	15	appos	_	_
20	of	of	IN	IN	_	21	case	_	_
21	leukocytes	leukocyte	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	While	while	IN	IN	_	4	mark	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	co-expressed	co-express	VBD	VBD	_	24	advcl	_	_
5	two	two	CD	CD	_	8	nummod	_	_
6	discrete	discrete	JJ	JJ	_	8	amod	_	_
7	cell-surface	cell-surface	JJ	JJ	_	8	amod	_	_
8	isoforms	isoform	NNS	NNS	_	4	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CD43	cd43	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	recognized	recognize	VBN	VBN	_	8	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	mAb	mab	NN	NN	_	15	compound	_	_
15	J393	j393	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mAb	mab	NN	NN	_	18	compound	_	_
18	G10-2	g10-2	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	respectively	respectively	RB	RB	_	15	advmod	_	_
21	,	,	,	,	_	24	punct	_	_
22	only	only	RB	RB	_	23	advmod	_	_
23	J393/CD43	j393/cd43	NN	NN	_	24	nsubj	_	_
24	signaled	signal	VBD	VBD	_	0	root	_	_
25	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
26	.	.	.	.	_	24	punct	_	_

1	J393/CD43	j393/cd43	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	hyposialylated	hyposialylate	VBN	VBN	_	3	xcomp	_	_
7	,	,	,	,	_	6	punct	_	_
8	bearing	bear	VBG	VBG	_	6	xcomp	_	_
9	predominantly	predominantly	RB	RB	_	10	advmod	_	_
10	O-linked	o-linked	JJ	JJ	_	12	amod	_	_
11	monosaccharide	monosaccharide	NN	NN	_	12	compound	_	_
12	glycans	glycan	NNS	NNS	_	8	dobj	_	_
13	,	,	,	,	_	3	punct	_	_
14	whereas	whereas	IN	IN	_	3	dep	_	_
15	G10-2/CD43	g10-2/cd43	NN	NN	_	16	nsubj	_	_
16	bore	bear	VBD	VBD	_	3	parataxis	_	_
17	complex	complex	JJ	JJ	_	18	dep	_	_
18	sialylated	sialylate	VBN	VBN	_	22	amod	_	_
19	tetra-	tetra-	JJ	JJ	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	hexasaccharide	hexasaccharide	NN	NN	_	19	conj	_	_
22	chains	chain	NNS	NNS	_	16	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	with	with	IN	IN	_	7	case	_	_
3	soluble	soluble	JJ	JJ	_	7	amod	_	_
4	,	,	,	,	_	3	punct	_	_
5	bivalent	bivalent	JJ	JJ	_	3	dep	_	_
6	mAb	mab	NN	NN	_	7	compound	_	_
7	J393	j393	NN	NN	_	1	nmod	_	_
8	killed	kill	VBD	VBD	_	0	root	_	_
9	25-50	25-50	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	population	population	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	while	while	IN	IN	_	31	mark	_	_
17	concomitant	concomitant	JJ	JJ	_	18	amod	_	_
18	engagement	engagement	NN	NN	_	31	nsubj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	either	either	CC	CC	_	23	cc:preconj	_	_
21	the	the	DT	DT	_	23	det	_	_
22	CD3.TcR	cd3.tcr	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	18	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	integrins	integrin	NNS	NNS	_	23	conj	_	_
27	CD18	cd18	NN	NN	_	26	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD29	cd29	NN	NN	_	27	conj	_	_
30	significantly	significantly	RB	RB	_	31	advmod	_	_
31	potentiated	potentiate	VBD	VBD	_	8	advcl	_	_
32	this	this	DT	DT	_	33	det	_	_
33	effect	effect	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	8	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Jurkat	jurkat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	mAb	mab	NN	NN	_	7	compound	_	_
7	J393	j393	NN	NN	_	1	nmod	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	substrates	substrate	NNS	NNS	_	10	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	underwent	undergo	VBD	VBD	_	14	acl:relcl	_	_
17	hyperphosphorylation	hyperphosphorylation	NN	NN	_	16	dobj	_	_
18	upon	upon	IN	IN	_	21	case	_	_
19	antigen	antigen	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	costimulation	costimulation	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
4	by	by	IN	IN	_	6	case	_	_
5	herbimycin	herbimycin	NN	NN	_	6	compound	_	_
6	A	a	NN	NN	_	3	nmod	_	_
7	diminished	diminish	VBD	VBD	_	0	root	_	_
8	J393/CD43-mediated	j393/cd43-mediated	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	whereas	whereas	IN	IN	_	7	dep	_	_
12	inhibition	inhibition	NN	NN	_	19	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	phosphotyrosine	phosphotyrosine	NN	NN	_	16	compound	_	_
15	phosphatase	phosphatase	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	bis(maltolato)oxovanadium-IV	bis(maltolato)oxovanadium-iv	NN	NN	_	12	nmod	_	_
19	enhanced	enhance	VBD	VBD	_	7	parataxis	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	death	death	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	transduction	transduction	NN	NN	_	8	nsubj	_	_
3	through	through	IN	IN	_	6	case	_	_
4	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	nmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	lead	lead	VB	VB	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	altered	altered	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	as	as	IN	IN	_	17	mark	_	_
15	J393/CD43	j393/cd43	NN	NN	_	16	compound	_	_
16	ligation	ligation	NN	NN	_	17	nsubj	_	_
17	prompted	prompt	VBD	VBD	_	8	advcl	_	_
18	decreases	decrease	NNS	NNS	_	17	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	localization	localization	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
26	regulatory	regulatory	JJ	JJ	_	28	amod	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	22	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	proteins	protein	NNS	NNS	_	28	conj	_	_
31	binding	bind	VBG	VBG	_	30	acl	_	_
32	the	the	DT	DT	_	35	det	_	_
33	interferon-inducible	interferon-inducible	JJ	JJ	_	35	amod	_	_
34	regulatory	regulatory	JJ	JJ	_	35	amod	_	_
35	element	element	NN	NN	_	31	dobj	_	_
36	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	peripheral	peripheral	JJ	JJ	_	4	amod	_	_
3	blood	blood	NN	NN	_	4	compound	_	_
4	T-lymphocytes	t-lymphocyte	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	14	advcl	_	_
6	cryptic	cryptic	JJ	JJ	_	7	amod	_	_
7	epitopes	epitope	NNS	NNS	_	5	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	mAb	mab	NN	NN	_	10	compound	_	_
10	J393	j393	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	these	these	DT	DT	_	13	det	_	_
13	findings	finding	NNS	NNS	_	14	nsubj	_	_
14	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	existence	existence	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	tightly	tightly	RB	RB	_	20	advmod	_	_
20	regulated	regulate	VBN	VBN	_	22	amod	_	_
21	CD43-mediated	cd43-mediated	JJ	JJ	_	22	amod	_	_
22	pathway	pathway	NN	NN	_	16	nmod	_	_
23	for	for	IN	IN	_	24	mark	_	_
24	inducing	induce	VBG	VBG	_	22	acl	_	_
25	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	lineages	lineage	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	14	punct	_	_

1	Stat3	stat3	NN	NN	_	2	compound	_	_
2	recruitment	recruitment	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	10	case	_	_
4	two	two	CD	CD	_	10	nummod	_	_
5	distinct	distinct	JJ	JJ	_	10	amod	_	_
6	ligand-induced	ligand-induced	JJ	JJ	_	10	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	6	dep	_	_
9	docking	docking	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	2	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	interleukin-10	interleukin-10	NN	NN	_	16	compound	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	domain	domain	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	IL-10	il-10	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
8	activation	activation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	JAK-STAT	jak-stat	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	38	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	underlying	underlie	VBG	VBG	_	4	acl	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transducer	transducer	NN	NN	_	16	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	activator	activator	NN	NN	_	7	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	transcription	transcription	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	STAT	stat	NN	NN	_	7	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	recruitment	recruitment	NN	NN	_	5	dobj	_	_
17	to	to	TO	TO	_	24	case	_	_
18	the	the	DT	DT	_	24	det	_	_
19	interleukin	interleukin	NN	NN	_	24	compound	_	_
20	10	10	CD	CD	_	19	nummod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IL-10	il-10	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	receptor	receptor	NN	NN	_	16	nmod	_	_
25	,	,	,	,	_	38	punct	_	_
26	the	the	DT	DT	_	28	det	_	_
27	STAT	stat	NN	NN	_	28	compound	_	_
28	proteins	protein	NNS	NNS	_	38	nsubjpass	_	_
29	activated	activate	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	31	case	_	_
31	IL-10	il-10	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	different	different	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	populations	population	NNS	NNS	_	29	nmod	_	_
36	were	be	VBD	VBD	_	38	auxpass	_	_
37	first	first	RB	RB	_	38	advmod	_	_
38	defined	define	VBN	VBN	_	0	root	_	_
39	using	use	VBG	VBG	_	38	xcomp	_	_
40	electrophoretic	electrophoretic	JJ	JJ	_	43	amod	_	_
41	mobility	mobility	NN	NN	_	43	compound	_	_
42	shift	shift	NN	NN	_	43	compound	_	_
43	assays	assay	NNS	NNS	_	39	dobj	_	_
44	.	.	.	.	_	38	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	all	all	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	tested	test	VBN	VBN	_	3	acl	_	_
5	,	,	,	,	_	7	punct	_	_
6	IL-10	il-10	NN	NN	_	7	nsubj	_	_
7	activated	activate	VBD	VBD	_	0	root	_	_
8	Stat1	stat1	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Stat3	stat3	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	induced	induce	VBD	VBD	_	7	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	formation	formation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	three	three	CD	CD	_	20	nummod	_	_
17	distinct	distinct	JJ	JJ	_	20	amod	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	complexes	complex	NNS	NNS	_	14	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	contained	contain	VBD	VBD	_	20	acl:relcl	_	_
23	different	different	JJ	JJ	_	24	amod	_	_
24	combinations	combination	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	these	these	DT	DT	_	29	det	_	_
27	two	two	CD	CD	_	29	nummod	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	IL-10	il-10	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	activated	activate	VBD	VBD	_	0	root	_	_
4	Stat5	stat5	NN	NN	_	3	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Ba/F3	ba/f3	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	that	that	IN	IN	_	10	nsubj	_	_
9	stably	stably	RB	RB	_	10	advmod	_	_
10	expressed	express	VBD	VBD	_	7	acl:relcl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	murine	murine	JJ	JJ	_	14	amod	_	_
13	IL-10	il-10	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	25	advcl	_	_
2	a	a	DT	DT	_	5	det	_	_
3	structure-function	structure-function	JJ	JJ	_	5	amod	_	_
4	mutagenesis	mutagenesis	NN	NN	_	5	compound	_	_
5	approach	approach	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	25	punct	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	residues	residue	NNS	NNS	_	25	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Tyr427	tyr427	NN	NN	_	9	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Tyr477	tyr477	NN	NN	_	11	conj	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	9	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	murine	murine	JJ	JJ	_	23	amod	_	_
22	IL-10	il-10	NN	NN	_	23	compound	_	_
23	receptor	receptor	NN	NN	_	18	nmod	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	found	find	VBN	VBN	_	0	root	_	_
26	to	to	TO	TO	_	29	mark	_	_
27	be	be	VB	VB	_	29	auxpass	_	_
28	redundantly	redundantly	RB	RB	_	29	advmod	_	_
29	required	require	VBN	VBN	_	25	xcomp	_	_
30	for	for	IN	IN	_	32	case	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	function	function	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	for	for	IN	IN	_	35	case	_	_
35	activation	activation	NN	NN	_	32	conj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	Stat3	stat3	NN	NN	_	35	nmod	_	_
38	but	but	CC	CC	_	37	cc	_	_
39	not	not	RB	RB	_	41	neg	_	_
40	for	for	IN	IN	_	41	case	_	_
41	Stat1	stat1	NN	NN	_	37	conj	_	_
42	or	or	CC	CC	_	41	cc	_	_
43	Stat5	stat5	NN	NN	_	41	conj	_	_
44	.	.	.	.	_	25	punct	_	_

1	Twelve	twelve	CD	CD	_	4	nummod	_	_
2	amino	amino	NN	NN	_	4	compound	_	_
3	acid	acid	NN	NN	_	4	compound	_	_
4	peptides	peptide	NNS	NNS	_	15	nsubj	_	_
5	encompassing	encompass	VBG	VBG	_	4	acl	_	_
6	either	either	DT	DT	_	5	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	these	these	DT	DT	_	11	det	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	residues	residue	NNS	NNS	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	phosphorylated	phosphorylated	JJ	JJ	_	14	amod	_	_
14	form	form	NN	NN	_	11	nmod	_	_
15	coprecipitated	coprecipitate	VBD	VBD	_	0	root	_	_
16	Stat3	stat3	NN	NN	_	15	dobj	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	Stat1	stat1	NN	NN	_	16	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	blocked	block	VBD	VBD	_	15	conj	_	_
22	IL-10-induced	il-10-induced	JJ	JJ	_	24	amod	_	_
23	Stat3	stat3	NN	NN	_	24	compound	_	_
24	phosphorylation	phosphorylation	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	cell-free	cell-free	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	5	amod	_	_
5	peptides	peptide	NNS	NNS	_	12	nsubj	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	Tyr374	tyr374	NN	NN	_	6	dobj	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	Tyr396	tyr396	NN	NN	_	7	conj	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	interact	interact	VB	VB	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	Stat3	stat3	NN	NN	_	12	nmod	_	_
15	or	or	CC	CC	_	12	cc	_	_
16	block	block	VB	VB	_	12	conj	_	_
17	Stat3	stat3	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	Stat3	stat3	NN	NN	_	13	nsubjpass	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	5	dep	_	_
8	Stat1	stat1	NN	NN	_	5	dep	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	Stat5	stat5	NN	NN	_	8	conj	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	directly	directly	RB	RB	_	13	advmod	_	_
13	recruited	recruit	VBN	VBN	_	3	ccomp	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	ligand-activated	ligand-activated	JJ	JJ	_	18	amod	_	_
17	IL-10	il-10	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	13	nmod	_	_
19	by	by	IN	IN	_	20	mark	_	_
20	binding	bind	VBG	VBG	_	13	advcl	_	_
21	to	to	TO	TO	_	28	case	_	_
22	specific	specific	JJ	JJ	_	28	amod	_	_
23	but	but	CC	CC	_	22	cc	_	_
24	redundant	redundant	JJ	JJ	_	22	conj	_	_
25	receptor	receptor	NN	NN	_	28	compound	_	_
26	intracellular	intracellular	JJ	JJ	_	28	amod	_	_
27	domain	domain	NN	NN	_	28	compound	_	_
28	sequences	sequence	NNS	NNS	_	20	nmod	_	_
29	containing	contain	VBG	VBG	_	28	acl	_	_
30	phosphotyrosine	phosphotyrosine	NN	NN	_	29	dobj	_	_
31	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	supports	support	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	concept	concept	NN	NN	_	4	dobj	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	utilization	utilization	NN	NN	_	18	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	distinct	distinct	JJ	JJ	_	12	amod	_	_
11	STAT	stat	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	different	different	JJ	JJ	_	16	amod	_	_
15	cytokine	cytokine	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	8	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	dependent	dependent	JJ	JJ	_	6	ccomp	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	29	case	_	_
23	particular	particular	JJ	JJ	_	29	amod	_	_
24	ligand-activatable	ligand-activatable	JJ	JJ	_	29	amod	_	_
25	,	,	,	,	_	24	punct	_	_
26	tyrosine-containing	tyrosine-containing	JJ	JJ	_	24	dep	_	_
27	STAT	stat	NN	NN	_	29	compound	_	_
28	docking	docking	NN	NN	_	29	compound	_	_
29	sites	site	NNS	NNS	_	21	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	receptor	receptor	NN	NN	_	33	compound	_	_
32	intracellular	intracellular	JJ	JJ	_	33	amod	_	_
33	domains	domain	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	leukocyte-specific	leukocyte-specific	JJ	JJ	_	7	amod	_	_
7	component	component	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	body	body	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	body	body	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	NB	nb	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	organelle	organelle	NN	NN	_	0	root	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	involved	involve	VBN	VBN	_	10	acl:relcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pathogenesis	pathogenesis	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	acute	acute	JJ	JJ	_	20	amod	_	_
19	promyelocytic	promyelocytic	JJ	JJ	_	20	amod	_	_
20	leukemia	leukemia	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	viral	viral	JJ	JJ	_	23	amod	_	_
23	infection	infection	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	NB	nb	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	also	also	RB	RB	_	6	advmod	_	_
5	a	a	DT	DT	_	6	det	_	_
6	target	target	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	serum	serum	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	autoimmune	autoimmune	JJ	JJ	_	20	amod	_	_
17	disease	disease	NN	NN	_	20	compound	_	_
18	primary	primary	JJ	JJ	_	20	amod	_	_
19	biliary	biliary	JJ	JJ	_	20	amod	_	_
20	cirrhosis	cirrhosis	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	serum	serum	NN	NN	_	14	nsubjpass	_	_
6	from	from	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	patient	patient	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	biliary	biliary	JJ	JJ	_	12	amod	_	_
12	cirrhosis	cirrhosis	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	used	use	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	identify	identify	VB	VB	_	14	xcomp	_	_
17	a	a	DT	DT	_	18	det	_	_
18	cDNA	cdna	NN	NN	_	16	dobj	_	_
19	encoding	encode	VBG	VBG	_	18	acl	_	_
20	a	a	DT	DT	_	22	det	_	_
21	novel	novel	JJ	JJ	_	22	amod	_	_
22	component	component	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	NB	nb	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	22	punct	_	_
27	a	a	DT	DT	_	29	det	_	_
28	140-kDa	140-kda	JJ	JJ	_	29	amod	_	_
29	protein	protein	NN	NN	_	22	appos	_	_
30	designated	designate	VBN	VBN	_	29	acl	_	_
31	Sp140	sp140	NN	NN	_	30	xcomp	_	_
32	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	predicted	predict	VBN	VBN	_	5	amod	_	_
3	amino	amino	NN	NN	_	5	compound	_	_
4	acid	acid	NN	NN	_	5	compound	_	_
5	sequence	sequence	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	amino-terminal	amino-terminal	JJ	JJ	_	9	amod	_	_
9	portion	portion	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Sp140	sp140	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	similar	similar	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	Sp100	sp100	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	21	det	_	_
18	previously	previously	RB	RB	_	19	advmod	_	_
19	identified	identify	VBN	VBN	_	21	amod	_	_
20	NB	nb	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	15	appos	_	_
22	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	carboxyl	carboxyl	JJ	JJ	_	3	amod	_	_
3	portion	portion	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Sp140	sp140	NN	NN	_	3	nmod	_	_
6	contained	contain	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	zinc-finger	zinc-finger	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	bromodomain	bromodomain	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	motifs	motif	NNS	NNS	_	9	appos	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	present	present	JJ	JJ	_	14	acl:relcl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	proteins	protein	NNS	NNS	_	17	nmod	_	_
20	regulating	regulate	VBG	VBG	_	19	acl	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	6	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Sp140	sp140	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	14	case	_	_
9	human	human	JJ	JJ	_	14	amod	_	_
10	spleen	spleen	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
13	blood	blood	NN	NN	_	10	conj	_	_
14	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	14	cc	_	_
18	other	other	JJ	JJ	_	20	amod	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	tissues	tissue	NNS	NNS	_	14	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	level	level	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	SP140	sp140	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
8	precursor	precursor	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	2	nmod	_	_
11	HL60	hl60	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	NB4	nb4	NN	NN	_	11	conj	_	_
14	markedly	markedly	RB	RB	_	15	advmod	_	_
15	increased	increase	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	22	case	_	_
17	response	response	NN	NN	_	22	dep	_	_
18	to	to	TO	TO	_	22	case	_	_
19	chemically	chemically	RB	RB	_	20	advmod	_	_
20	induced	induce	VBN	VBN	_	22	amod	_	_
21	cellular	cellular	JJ	JJ	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	2	amod	_	_
2	techniques	technique	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	demonstrate	demonstrate	VB	VB	_	4	xcomp	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	SP140	sp140	NN	NN	_	9	nsubj	_	_
9	localized	localize	VBD	VBD	_	6	ccomp	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	NB	nb	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	18	case	_	_
14	differentiated	differentiate	VBN	VBN	_	18	amod	_	_
15	HL60	hl60	NN	NN	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NB4	nb4	NN	NN	_	15	conj	_	_
18	cells	cell	NNS	NNS	_	9	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	location	location	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Sp140	sp140	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	NB	nb	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	expression	expression	NN	NN	_	2	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	involved	involve	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	host	host	NN	NN	_	19	compound	_	_
19	defense	defense	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	2	punct	_	_
21	suggest	suggest	VBP	VBP	_	0	root	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	Sp140	sp140	NN	NN	_	26	nsubjpass	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	involved	involve	VBN	VBN	_	21	ccomp	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	pathogenesis	pathogenesis	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	acute	acute	JJ	JJ	_	33	amod	_	_
32	promyelocytic	promyelocytic	JJ	JJ	_	33	amod	_	_
33	leukemia	leukemia	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	viral	viral	JJ	JJ	_	36	amod	_	_
36	infection	infection	NN	NN	_	33	conj	_	_
37	.	.	.	.	_	21	punct	_	_

1	T-cell-directed	t-cell-directed	JJ	JJ	_	3	amod	_	_
2	TAL-1	tal-1	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	malignancies	malignancy	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	transgenic	transgenic	JJ	JJ	_	9	amod	_	_
9	mice	mouse	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TAL-1	tal-1	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	4	nsubj	_	_
4	specifies	specify	VBZ	VBZ	_	0	root	_	_
5	for	for	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	basic	basic	JJ	JJ	_	9	amod	_	_
8	domain-helix-loop-helix	domain-helix-loop-helix	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	involved	involve	VBN	VBN	_	9	acl:relcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	control	control	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	hematopoiesis	hematopoiesis	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	pathology	pathology	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	8	det	_	_
6	TAL-1	tal-1	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	product	product	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	percentage	percentage	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	T-cell	t-cell	NN	NN	_	19	compound	_	_
17	acute	acute	JJ	JJ	_	19	amod	_	_
18	lymphoblastic	lymphoblastic	JJ	JJ	_	19	amod	_	_
19	leukemias	leukemia	NNS	NNS	_	14	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	pediatric	pediatric	JJ	JJ	_	24	amod	_	_
23	age	age	NN	NN	_	24	compound	_	_
24	range	range	NN	NN	_	10	nmod	_	_
25	;	;	:	:	_	10	punct	_	_
26	however	however	RB	RB	_	32	advmod	_	_
27	,	,	,	,	_	32	punct	_	_
28	it	it	PRP	PRP	_	32	nsubjpass	_	_
29	has	have	VBZ	VBZ	_	32	aux	_	_
30	not	not	RB	RB	_	32	neg	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	established	establish	VBN	VBN	_	10	parataxis	_	_
33	whether	whether	IN	IN	_	36	mark	_	_
34	the	the	DT	DT	_	35	det	_	_
35	expression	expression	NN	NN	_	36	nsubj	_	_
36	has	have	VBZ	VBZ	_	32	ccomp	_	_
37	a	a	DT	DT	_	39	det	_	_
38	causal	causal	JJ	JJ	_	39	amod	_	_
39	role	role	NN	NN	_	36	dobj	_	_
40	in	in	IN	IN	_	41	case	_	_
41	oncogenesis	oncogenesis	NN	NN	_	36	nmod	_	_
42	.	.	.	.	_	32	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	phenotype	phenotype	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	mouse	mouse	NN	NN	_	12	compound	_	_
11	transgenic	transgenic	JJ	JJ	_	12	amod	_	_
12	lines	line	NNS	NNS	_	8	nmod	_	_
13	obtained	obtain	VBN	VBN	_	8	acl	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	13	advcl	_	_
16	tal-1	tal-1	NN	NN	_	18	compound	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	lymphoid	lymphoid	JJ	JJ	_	21	amod	_	_
21	tissues	tissue	NNS	NNS	_	18	nmod	_	_
22	using	use	VBG	VBG	_	15	advcl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	LCK	lck	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	survival	survival	NN	NN	_	3	compound	_	_
3	rate	rate	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	tal-1	tal-1	NN	NN	_	7	compound	_	_
6	transgenic	transgenic	JJ	JJ	_	7	amod	_	_
7	animals	animal	NNS	NNS	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	much	much	RB	RB	_	10	advmod	_	_
10	lower	lower	JJR	JJR	_	0	root	_	_
11	as	as	IN	IN	_	12	mark	_	_
12	compared	compare	VBN	VBN	_	10	advcl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	control	control	NN	NN	_	15	compound	_	_
15	mice	mouse	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Histopathological	histopathological	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	lymphomas	lymphoma	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	type	type	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	often	often	RB	RB	_	10	advmod	_	_
10	comprising	comprise	VBG	VBG	_	4	acl	_	_
11	a	a	DT	DT	_	14	det	_	_
12	minor	minor	JJ	JJ	_	14	amod	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	component	component	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	mice	mouse	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	marked	marked	JJ	JJ	_	7	amod	_	_
5	splenic	splenic	JJ	JJ	_	7	amod	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	depletion	depletion	NN	NN	_	3	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	Primary	primary	JJ	JJ	_	3	amod	_	_
2	lymphocyte	lymphocyte	NN	NN	_	3	compound	_	_
3	cultures	culture	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	partial	partial	JJ	JJ	_	6	amod	_	_
6	independence	independence	NN	NN	_	4	dobj	_	_
7	from	from	IN	IN	_	10	case	_	_
8	exogenous	exogenous	JJ	JJ	_	10	amod	_	_
9	growth	growth	NN	NN	_	10	compound	_	_
10	stimuli	stimulus	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	increased	increase	VBD	VBD	_	4	conj	_	_
13	resistance	resistance	NN	NN	_	12	dobj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	low-serum	low-serum	JJ	JJ	_	16	amod	_	_
16	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	unravel	unravel	VB	VB	_	16	advcl	_	_
4	the	the	DT	DT	_	7	det	_	_
5	tal-1	tal-1	NN	NN	_	7	compound	_	_
6	oncogenic	oncogenic	JJ	JJ	_	7	amod	_	_
7	potential	potential	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	16	punct	_	_
9	a	a	DT	DT	_	10	det	_	_
10	strain	strain	NN	NN	_	16	nsubjpass	_	_
11	of	of	IN	IN	_	14	case	_	_
12	tal-1	tal-1	NN	NN	_	14	compound	_	_
13	transgenic	transgenic	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	10	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	crossbred	crossbreed	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	p53-/-	p53-/-	JJ	JJ	_	19	amod	_	_
19	mice	mouse	NNS	NNS	_	16	nmod	_	_
20	;	;	:	:	_	16	punct	_	_
21	the	the	DT	DT	_	23	det	_	_
22	survival	survival	NN	NN	_	23	compound	_	_
23	rate	rate	NN	NN	_	28	nsubjpass	_	_
24	in	in	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	animals	animal	NNS	NNS	_	23	nmod	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	reduced	reduce	VBN	VBN	_	16	parataxis	_	_
29	by	by	IN	IN	_	32	case	_	_
30	more	more	JJR	JJR	_	32	advmod	_	_
31	than	than	IN	IN	_	30	mwe	_	_
32	one-half	one-half	NN	NN	_	28	nmod	_	_
33	when	when	WRB	WRB	_	34	advmod	_	_
34	compared	compare	VBN	VBN	_	28	advcl	_	_
35	with	with	IN	IN	_	36	case	_	_
36	that	that	DT	DT	_	34	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	tal-1	tal-1	NN	NN	_	39	compound	_	_
39	mice	mouse	NNS	NNS	_	36	nmod	_	_
40	,	,	,	,	_	28	punct	_	_
41	and	and	CC	CC	_	28	cc	_	_
42	histopathological	histopathological	JJ	JJ	_	43	amod	_	_
43	analysis	analysis	NN	NN	_	44	nsubj	_	_
44	revealed	reveal	VBD	VBD	_	28	conj	_	_
45	exclusively	exclusively	RB	RB	_	44	advmod	_	_
46	T-cell	t-cell	NN	NN	_	47	compound	_	_
47	lymphomas	lymphoma	NNS	NNS	_	44	dobj	_	_
48	.	.	.	.	_	28	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	TAL-1	tal-1	NN	NN	_	17	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	expressed	express	VBN	VBN	_	5	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	is	be	VBZ	VBZ	_	17	cop	_	_
13	per	per	FW	FW	_	14	compound	_	_
14	se	se	FW	FW	_	17	advmod	_	_
15	a	a	DT	DT	_	17	det	_	_
16	potent	potent	JJ	JJ	_	17	amod	_	_
17	oncogene	oncogene	NN	NN	_	3	ccomp	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	exert	exert	VB	VB	_	17	acl:relcl	_	_
22	a	a	DT	DT	_	25	det	_	_
23	key	key	JJ	JJ	_	25	amod	_	_
24	leukemogenetic	leukemogenetic	JJ	JJ	_	25	amod	_	_
25	role	role	NN	NN	_	21	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	majority	majority	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	T-cell	t-cell	NN	NN	_	33	compound	_	_
31	acute	acute	JJ	JJ	_	33	amod	_	_
32	lymphoblastic	lymphoblastic	JJ	JJ	_	33	amod	_	_
33	leukemias	leukemia	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Naive	naive	JJ	JJ	_	6	amod	_	_
2	(	(	-LRB-	-LRB-	_	6	punct	_	_
3	CD45RA+	cd45ra+	JJ	JJ	_	6	amod	_	_
4	)	)	-RRB-	-RRB-	_	6	punct	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	9	nsubj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	sensitive	sensitive	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	oxidative	oxidative	JJ	JJ	_	12	amod	_	_
12	stress-induced	stress-induced	JJ	JJ	_	13	amod	_	_
13	signals	signal	NNS	NNS	_	9	nmod	_	_
14	than	than	IN	IN	_	19	case	_	_
15	memory	memory	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	CD45RO+	cd45ro+	JJ	JJ	_	19	amod	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	cells	cell	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Formation	formation	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	reactive	reactive	JJ	JJ	_	5	amod	_	_
4	oxygen	oxygen	NN	NN	_	5	compound	_	_
5	intermediates	intermediate	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ROI	roi	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	after	after	IN	IN	_	11	case	_	_
10	oxidative	oxidative	JJ	JJ	_	11	amod	_	_
11	stress	stress	NN	NN	_	1	nmod	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	19	mark	_	_
16	be	be	VB	VB	_	19	cop	_	_
17	an	a	DT	DT	_	19	det	_	_
18	activation	activation	NN	NN	_	19	compound	_	_
19	signal	signal	NN	NN	_	14	xcomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	19	punct	_	_
24	e.g.	e.g.	FW	FW	_	33	advmod	_	_
25	,	,	,	,	_	33	punct	_	_
26	expression	expression	NN	NN	_	33	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
31	receptor	receptor	NN	NN	_	28	conj	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	induced	induce	VBN	VBN	_	19	parataxis	_	_
34	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	ROI-induced	roi-induced	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	12	nsubjpass	_	_
4	can	can	MD	MD	_	12	aux	_	_
5	,	,	,	,	_	12	punct	_	_
6	to	to	TO	TO	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	large	large	JJ	JJ	_	9	amod	_	_
9	extent	extent	NN	NN	_	12	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	attributed	attribute	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Now	now	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	whether	whether	IN	IN	_	11	mark	_	_
6	naive	naive	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	memory	memory	NN	NN	_	6	conj	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	11	nsubj	_	_
11	differ	differ	VBP	VBP	_	4	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	sensitivity	sensitivity	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	ROI-mediated	roi-mediated	JJ	JJ	_	17	amod	_	_
17	signals	signal	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	15	advmod	_	_
2	CD45RA+	cd45ra+	JJ	JJ	_	12	amod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	naive	naive	JJ	JJ	_	2	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	CD45RO+	cd45ro+	JJ	JJ	_	2	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	memory	memory	NN	NN	_	7	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	15	nsubjpass	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	directly	directly	RB	RB	_	15	advmod	_	_
15	stimulated	stimulate	VBN	VBN	_	23	advcl	_	_
16	with	with	IN	IN	_	17	case	_	_
17	H2O2	h2o2	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	23	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	21	compound	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	translocation	translocation	NN	NN	_	23	nsubj	_	_
22	was	be	VBD	VBD	_	23	cop	_	_
23	stronger	stronger	JJR	JJR	_	0	root	_	_
24	in	in	IN	IN	_	26	case	_	_
25	naive	naive	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	than	than	IN	IN	_	30	case	_	_
28	in	in	IN	IN	_	30	case	_	_
29	memory	memory	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	23	advcl	_	_
31	and	and	CC	CC	_	23	cc	_	_
32	it	it	PRP	PRP	_	35	nsubjpass	_	_
33	could	could	MD	MD	_	35	aux	_	_
34	be	be	VB	VB	_	35	auxpass	_	_
35	induced	induce	VBN	VBN	_	23	conj	_	_
36	with	with	IN	IN	_	38	case	_	_
37	lower	lower	JJR	JJR	_	38	amod	_	_
38	doses	dose	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	composition	composition	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	induced	induce	VBN	VBN	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	levels	level	NNS	NNS	_	2	dep	_	_
10	of	of	IN	IN	_	14	case	_	_
11	p50	p50	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	RelA	rela	NN	NN	_	11	conj	_	_
14	proteins	protein	NNS	NNS	_	9	nmod	_	_
15	)	)	-RRB-	-RRB-	_	9	punct	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	similar	similar	JJ	JJ	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	these	these	DT	DT	_	21	det	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	types	type	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	kinetics	kinetics	NNS	NNS	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
7	ROI	roi	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	there	there	EX	EX	_	14	expl	_	_
14	were	be	VBD	VBD	_	11	ccomp	_	_
15	no	no	DT	DT	_	16	neg	_	_
16	differences	difference	NNS	NNS	_	14	nsubj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	ROI-forming	roi-forming	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	14	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	antioxidative	antioxidative	JJ	JJ	_	22	amod	_	_
22	capacities	capacity	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	probable	probable	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	point	point	NN	NN	_	9	nsubj	_	_
5	was	be	VBD	VBD	_	9	cop	_	_
6	the	the	DT	DT	_	9	det	_	_
7	cytoplasmic	cytoplasmic	JJ	JJ	_	9	amod	_	_
8	IkappaB	ikappab	NN	NN	_	9	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	0	root	_	_
10	:	:	:	:	_	9	punct	_	_
11	in	in	IN	IN	_	13	case	_	_
12	CD45RA+	cd45ra+	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	16	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	H2O2	h2o2	NN	NN	_	16	nsubj	_	_
16	caused	cause	VBD	VBD	_	9	parataxis	_	_
17	a	a	DT	DT	_	20	det	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	profound	profound	JJ	JJ	_	20	amod	_	_
20	depression	depression	NN	NN	_	16	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	levels	level	NNS	NNS	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	IkappaB	ikappab	NN	NN	_	26	compound	_	_
26	alpha	alpha	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	16	nsubj	_	_
7	representing	represent	VBG	VBG	_	6	acl	_	_
8	different	different	JJ	JJ	_	12	amod	_	_
9	activation	activation	NN	NN	_	12	compound	_	_
10	and/or	and/or	CC	CC	_	9	cc	_	_
11	differentiation	differentiation	NN	NN	_	9	conj	_	_
12	stages	stage	NNS	NNS	_	7	dobj	_	_
13	can	can	MD	MD	_	16	aux	_	_
14	be	be	VB	VB	_	16	cop	_	_
15	differentially	differentially	RB	RB	_	16	advmod	_	_
16	responsive	responsive	JJ	JJ	_	3	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	ROI-mediated	roi-mediated	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Potent	potent	JJ	JJ	_	6	amod	_	_
2	gene	gene	NN	NN	_	6	compound	_	_
3	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	antiproliferative	antiproliferative	JJ	JJ	_	3	conj	_	_
6	activities	activity	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	9	case	_	_
8	20-methyl	20-methyl	JJ	JJ	_	9	amod	_	_
9	analogues	analogue	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	1,25	1,25	CD	CD	_	13	nummod	_	_
12	dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	13	compound	_	_
13	D3	d3	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	biological	biological	JJ	JJ	_	4	amod	_	_
3	active	active	JJ	JJ	_	4	amod	_	_
4	form	form	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	vitamin	vitamin	NN	NN	_	7	compound	_	_
7	D3	d3	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	10	compound	_	_
10	D3	d3	NN	NN	_	4	appos	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	VD	vd	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	4	punct	_	_
15	regulates	regulate	VBZ	VBZ	_	0	root	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	growth	growth	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	differentiation	differentiation	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	provides	provide	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hormone	hormone	NN	NN	_	2	dobj	_	_
5	with	with	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	interesting	interesting	JJ	JJ	_	9	amod	_	_
8	therapeutic	therapeutic	JJ	JJ	_	9	amod	_	_
9	potential	potential	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	hypercalcemia	hypercalcemia	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	side	side	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	caused	cause	VBN	VBN	_	7	acl:relcl	_	_
12	by	by	IN	IN	_	16	case	_	_
13	VD	vd	NN	NN	_	16	nmod:poss	_	_
14	's	's	POS	POS	_	13	case	_	_
15	classical	classical	JJ	JJ	_	16	amod	_	_
16	action	action	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	16	appos	_	_
20	of	of	IN	IN	_	22	case	_	_
21	calcium	calcium	NN	NN	_	22	compound	_	_
22	homeostasis	homeostasis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	made	make	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	need	need	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	VD	vd	NN	NN	_	7	compound	_	_
7	analogues	analogue	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	selectively	selectively	RB	RB	_	10	advmod	_	_
10	increased	increase	VBN	VBN	_	13	amod	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	properties	property	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Studies	study	NNS	NNS	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	20-epi	20-epi	JJ	JJ	_	4	amod	_	_
4	analogues	analogue	NNS	NNS	_	1	nmod	_	_
5	pointed	point	VBD	VBD	_	0	root	_	_
6	out	out	RP	RP	_	5	compound:prt	_	_
7	the	the	DT	DT	_	8	det	_	_
8	importance	importance	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	carbon-20	carbon-20	NN	NN	_	12	compound	_	_
12	position	position	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	led	lead	VBD	VBD	_	5	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	20-methyl	20-methyl	NN	NN	_	20	compound	_	_
20	derivatives	derivative	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	VD	vd	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	24	nmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	biological	biological	JJ	JJ	_	6	amod	_	_
6	properties	property	NNS	NNS	_	24	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	compounds	compound	NNS	NNS	_	6	nmod	_	_
10	ZK161422	zk161422	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	ZK157202	zk157202	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	which	which	WDT	WDT	_	16	nsubj	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	20-methyl-	20-methyl-	NN	NN	_	9	acl:relcl	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	20-methyl-23-eneanalogues	20-methyl-23-eneanalogues	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	respectively	respectively	RB	RB	_	16	advmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	analyzed	analyze	VBN	VBN	_	0	root	_	_
25	in	in	IN	IN	_	28	case	_	_
26	comparison	comparison	NN	NN	_	28	dep	_	_
27	with	with	IN	IN	_	28	case	_	_
28	VD	vd	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	24	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	compounds	compound	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	about	about	IN	IN	_	5	case	_	_
5	2-fold	2-fold	RB	RB	_	6	advmod	_	_
6	lower	lower	JJR	JJR	_	7	amod	_	_
7	affinity	affinity	NN	NN	_	3	dobj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	VD	vd	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	VDR	vdr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	than	than	IN	IN	_	16	case	_	_
16	VD	vd	NN	NN	_	7	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	compared	compare	VBN	VBN	_	14	advcl	_	_
4	to	to	TO	TO	_	5	case	_	_
5	VD	vd	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
8	antiproliferative	antiproliferative	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	14	nsubj	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	up	up	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	30-fold	30-fold	RB	RB	_	14	advmod	_	_
14	higher	higher	JJR	JJR	_	0	root	_	_
15	on	on	IN	IN	_	20	case	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
18	blood	blood	NN	NN	_	20	compound	_	_
19	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	even	even	RB	RB	_	26	advmod	_	_
23	up	up	RB	RB	_	25	advmod	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	300-fold	300-fold	RB	RB	_	26	advmod	_	_
26	higher	higher	JJR	JJR	_	14	conj	_	_
27	on	on	IN	IN	_	32	case	_	_
28	human	human	JJ	JJ	_	32	amod	_	_
29	breast	breast	NN	NN	_	32	compound	_	_
30	cancer	cancer	NN	NN	_	32	compound	_	_
31	MCF-7	mcf-7	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Whereas	whereas	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	hypercalcemic	hypercalcemic	JJ	JJ	_	4	amod	_	_
4	effect	effect	NN	NN	_	9	nsubjpass	_	_
5	for	for	IN	IN	_	6	case	_	_
6	ZK157202	zk157202	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	increased	increase	VBN	VBN	_	13	advcl	_	_
10	10-fold	10-fold	RB	RB	_	9	advmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	ZK161422	zk161422	NN	NN	_	13	nsubj	_	_
13	has	have	VBZ	VBZ	_	0	root	_	_
14	the	the	DT	DT	_	17	det	_	_
15	same	same	JJ	JJ	_	17	amod	_	_
16	calcium-mobilizing	calcium-mobilizing	JJ	JJ	_	17	amod	_	_
17	potency	potency	NN	NN	_	13	dobj	_	_
18	as	as	IN	IN	_	19	case	_	_
19	VD	vd	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	ZK161422	zk161422	NN	NN	_	9	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	but	but	CC	CC	_	6	cc	_	_
6	not	not	RB	RB	_	3	cc	_	_
7	ZK157202	zk157202	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	preference	preference	NN	NN	_	9	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	promoter	promoter	NN	NN	_	13	nmod	_	_
17	carrying	carry	VBG	VBG	_	16	acl	_	_
18	a	a	DT	DT	_	21	det	_	_
19	VD	vd	NN	NN	_	21	compound	_	_
20	response	response	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	17	dobj	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	palindromic	palindromic	JJ	JJ	_	25	amod	_	_
25	arrangement	arrangement	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	two	two	CD	CD	_	31	nummod	_	_
28	hexameric	hexameric	JJ	JJ	_	31	amod	_	_
29	receptor	receptor	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	25	nmod	_	_
32	spaced	space	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	9	9	CD	CD	_	35	nummod	_	_
35	nucleotides	nucleotide	NNS	NNS	_	32	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	IP9	ip9	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	rather	rather	RB	RB	_	13	cc	_	_
40	than	than	IN	IN	_	39	mwe	_	_
41	for	for	IN	IN	_	42	case	_	_
42	activation	activation	NN	NN	_	13	conj	_	_
43	from	from	IN	IN	_	46	case	_	_
44	a	a	DT	DT	_	46	det	_	_
45	response	response	NN	NN	_	46	compound	_	_
46	element	element	NN	NN	_	42	nmod	_	_
47	formed	form	VBN	VBN	_	46	acl	_	_
48	by	by	IN	IN	_	51	case	_	_
49	a	a	DT	DT	_	51	det	_	_
50	direct	direct	JJ	JJ	_	51	amod	_	_
51	repeat	repeat	NN	NN	_	47	nmod	_	_
52	spaced	space	VBN	VBN	_	51	acl	_	_
53	by	by	IN	IN	_	55	case	_	_
54	3	3	CD	CD	_	55	nummod	_	_
55	nucleotides	nucleotide	NNS	NNS	_	52	nmod	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	DR3	dr3	NN	NN	_	51	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	3	nsubj	_	_
3	supports	support	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	11	nmod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	selectivity	selectivity	NN	NN	_	11	nsubj	_	_
11	reflects	reflect	VBZ	VBZ	_	5	acl:relcl	_	_
12	the	the	DT	DT	_	16	det	_	_
13	selectively	selectively	RB	RB	_	14	advmod	_	_
14	increased	increase	VBN	VBN	_	16	amod	_	_
15	antiproliferative	antiproliferative	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	VD	vd	NN	NN	_	19	compound	_	_
19	analogues	analogue	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interferon	interferon	NN	NN	_	2	nsubj	_	_
2	augments	augment	VBZ	VBZ	_	0	root	_	_
3	PML	pml	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	PML/RAR	pml/rar	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	3	conj	_	_
7	expression	expression	NN	NN	_	2	dobj	_	_
8	in	in	IN	IN	_	14	case	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	acute	acute	JJ	JJ	_	13	amod	_	_
13	promyelocytic	promyelocytic	JJ	JJ	_	10	conj	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	cooperates	cooperate	VBZ	VBZ	_	2	conj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	all-trans	all-trans	JJ	JJ	_	20	amod	_	_
19	retinoic	retinoic	JJ	JJ	_	20	amod	_	_
20	acid	acid	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	induce	induce	VB	VB	_	16	xcomp	_	_
23	maturation	maturation	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	29	case	_	_
25	a	a	DT	DT	_	29	det	_	_
26	retinoid-resistant	retinoid-resistant	JJ	JJ	_	29	amod	_	_
27	promyelocytic	promyelocytic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PML	pml	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	fused	fuse	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	retinoic	retinoic	JJ	JJ	_	12	amod	_	_
9	acid	acid	NN	NN	_	12	compound	_	_
10	receptor	receptor	NN	NN	_	12	compound	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	RAR	rar	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	28	case	_	_
18	the	the	DT	DT	_	28	det	_	_
19	acute	acute	JJ	JJ	_	21	amod	_	_
20	promyelocytic	promyelocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	28	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	APL	apl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	15	15	CD	CD	_	28	nummod	_	_
26	;	;	:	:	_	28	punct	_	_
27	17	17	CD	CD	_	28	nummod	_	_
28	translocation	translocation	NN	NN	_	5	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	PML	pml	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	diverse	diverse	JJ	JJ	_	6	amod	_	_
6	tissues	tissue	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	6	conj	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	localized	localized	JJ	JJ	_	3	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	nucleus	nucleus	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	typical	typical	JJ	JJ	_	19	amod	_	_
18	speckled	speckled	JJ	JJ	_	19	amod	_	_
19	pattern	pattern	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	bone	bone	NN	NN	_	4	compound	_	_
4	marrow	marrow	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	it	it	PRP	PRP	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	preferentially	preferentially	RB	RB	_	9	advmod	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	PML	pml	NN	NN	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	6	mark	_	_
4	be	be	VB	VB	_	6	aux	_	_
5	transcriptionally	transcriptionally	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	2	xcomp	_	_
7	by	by	IN	IN	_	12	case	_	_
8	class	class	NN	NN	_	12	compound	_	_
9	I	i	CD	CD	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	II	ii	CD	CD	_	9	conj	_	_
12	interferons	interferon	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	raises	raise	VBZ	VBZ	_	6	ccomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	possibility	possibility	NN	NN	_	15	dobj	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	interferons	interferon	NNS	NNS	_	20	nsubj	_	_
20	modulate	modulate	VBP	VBP	_	17	ccomp	_	_
21	the	the	DT	DT	_	27	det	_	_
22	function	function	NN	NN	_	27	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	growth	growth	NN	NN	_	22	conj	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	differentiation	differentiation	NN	NN	_	22	conj	_	_
27	potential	potential	NN	NN	_	20	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	normal	normal	JJ	JJ	_	31	amod	_	_
30	myeloid	myeloid	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	precursors	precursor	NNS	NNS	_	31	conj	_	_
34	by	by	IN	IN	_	35	mark	_	_
35	activating	activate	VBG	VBG	_	20	advcl	_	_
36	PML-dependent	pml-dependent	JJ	JJ	_	37	amod	_	_
37	pathways	pathway	NNS	NNS	_	35	dobj	_	_
38	.	.	.	.	_	2	punct	_	_

1	Similarly	similarly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	interferons	interferon	NNS	NNS	_	5	nsubj	_	_
4	could	could	MD	MD	_	5	aux	_	_
5	act	act	VB	VB	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	APL	apl	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	alone	alone	RB	RB	_	11	advmod	_	_
11	or	or	CC	CC	_	5	advmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	combination	combination	NN	NN	_	11	conj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	all-trans	all-trans	JJ	JJ	_	17	amod	_	_
16	retinoic	retinoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	RA	ra	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	5	punct	_	_
22	especially	especially	RB	RB	_	35	advmod	_	_
23	if	if	IN	IN	_	35	mark	_	_
24	the	the	DT	DT	_	28	det	_	_
25	PML/RAR	pml/rar	NN	NN	_	28	compound	_	_
26	alpha	alpha	NN	NN	_	28	compound	_	_
27	fusion	fusion	NN	NN	_	28	compound	_	_
28	transcript	transcript	NN	NN	_	35	nsubjpass	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	results	result	VBZ	VBZ	_	28	acl:relcl	_	_
31	from	from	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	t(15;17)	t(15;17)	NN	NN	_	30	nmod	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	induced	induce	VBN	VBN	_	5	advcl	_	_
36	by	by	IN	IN	_	37	case	_	_
37	interferon	interferon	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PML	pml	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	2	ccomp	_	_
8	at	at	IN	IN	_	10	case	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	7	nmod	_	_
11	or	or	CC	CC	_	7	cc	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	expressed	express	VBN	VBN	_	7	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	normal	normal	JJ	JJ	_	18	amod	_	_
16	circulating	circulate	VBG	VBG	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	polymorphonucleate	polymorphonucleate	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	18	conj	_	_
25	,	,	,	,	_	7	punct	_	_
26	but	but	CC	CC	_	7	cc	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	markedly	markedly	RB	RB	_	29	advmod	_	_
29	induced	induce	VBN	VBN	_	7	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	interferon	interferon	NN	NN	_	29	nmod	_	_
32	;	;	:	:	_	7	punct	_	_
33	that	that	IN	IN	_	40	mark	_	_
34	PML	pml	NN	NN	_	38	compound	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	PML/RAR	pml/rar	NN	NN	_	37	compound	_	_
37	alpha	alpha	NN	NN	_	34	conj	_	_
38	expression	expression	NN	NN	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	augmented	augment	VBN	VBN	_	7	conj	_	_
41	by	by	IN	IN	_	42	case	_	_
42	interferon	interferon	NN	NN	_	40	nmod	_	_
43	in	in	IN	IN	_	48	case	_	_
44	the	the	DT	DT	_	48	det	_	_
45	NB4	nb4	NN	NN	_	48	compound	_	_
46	APL	apl	NN	NN	_	48	compound	_	_
47	cell	cell	NN	NN	_	48	compound	_	_
48	line	line	NN	NN	_	40	nmod	_	_
49	,	,	,	,	_	48	punct	_	_
50	which	which	WDT	WDT	_	51	nsubj	_	_
51	carries	carry	VBZ	VBZ	_	48	acl:relcl	_	_
52	the	the	DT	DT	_	53	det	_	_
53	t(15;17)	t(15;17)	NN	NN	_	51	dobj	_	_
54	,	,	,	,	_	48	punct	_	_
55	and	and	CC	CC	_	48	cc	_	_
56	in	in	IN	IN	_	58	case	_	_
57	APL	apl	NN	NN	_	58	compound	_	_
58	blasts	blast	NNS	NNS	_	48	conj	_	_
59	from	from	IN	IN	_	60	case	_	_
60	patients	patient	NNS	NNS	_	58	nmod	_	_
61	;	;	:	:	_	7	punct	_	_
62	that	that	IN	IN	_	64	mark	_	_
63	interferon	interferon	NN	NN	_	64	nsubj	_	_
64	inhibits	inhibit	VBZ	VBZ	_	7	conj	_	_
65	growth	growth	NN	NN	_	64	dobj	_	_
66	and	and	CC	CC	_	65	cc	_	_
67	survival	survival	NN	NN	_	65	conj	_	_
68	of	of	IN	IN	_	71	case	_	_
69	NB4	nb4	NN	NN	_	71	compound	_	_
70	APL	apl	NN	NN	_	71	compound	_	_
71	cells	cell	NNS	NNS	_	65	nmod	_	_
72	in	in	IN	IN	_	75	case	_	_
73	cooperation	cooperation	NN	NN	_	75	dep	_	_
74	with	with	IN	IN	_	75	case	_	_
75	RA	ra	NN	NN	_	64	nmod	_	_
76	;	;	:	:	_	7	punct	_	_
77	that	that	IN	IN	_	80	mark	_	_
78	interferons	interferon	NNS	NNS	_	80	nsubj	_	_
79	alone	alone	RB	RB	_	78	advmod	_	_
80	have	have	VBP	VBP	_	7	conj	_	_
81	minimal	minimal	JJ	JJ	_	83	amod	_	_
82	maturation	maturation	NN	NN	_	83	compound	_	_
83	effect	effect	NN	NN	_	80	dobj	_	_
84	on	on	IN	IN	_	86	case	_	_
85	NB4	nb4	NN	NN	_	86	compound	_	_
86	cells	cell	NNS	NNS	_	80	nmod	_	_
87	;	;	:	:	_	7	punct	_	_
88	and	and	CC	CC	_	7	cc	_	_
89	,	,	,	,	_	7	punct	_	_
90	finally	finally	RB	RB	_	102	advmod	_	_
91	,	,	,	,	_	102	punct	_	_
92	that	that	IN	IN	_	102	mark	_	_
93	interferon	interferon	NN	NN	_	102	nsubj	_	_
94	gamma	gamma	NN	NN	_	93	dep	_	_
95	,	,	,	,	_	94	punct	_	_
96	but	but	CC	CC	_	97	cc	_	_
97	not	not	RB	RB	_	94	cc	_	_
98	alpha	alpha	NN	NN	_	94	conj	_	_
99	or	or	CC	CC	_	98	cc	_	_
100	beta	beta	NN	NN	_	98	conj	_	_
101	,	,	,	,	_	94	punct	_	_
102	induces	induce	VBZ	VBZ	_	7	conj	_	_
103	maturation	maturation	NN	NN	_	102	dobj	_	_
104	and	and	CC	CC	_	103	cc	_	_
105	growth	growth	NN	NN	_	106	compound	_	_
106	suppression	suppression	NN	NN	_	103	conj	_	_
107	of	of	IN	IN	_	109	case	_	_
108	NB4	nb4	NN	NN	_	109	compound	_	_
109	cells	cell	NNS	NNS	_	103	nmod	_	_
110	with	with	IN	IN	_	114	case	_	_
111	de	de	FW	FW	_	114	amod	_	_
112	novo	novo	FW	FW	_	111	dep	_	_
113	retinoid	retinoid	NN	NN	_	114	compound	_	_
114	resistance	resistance	NN	NN	_	109	nmod	_	_
115	,	,	,	,	_	102	punct	_	_
116	and	and	CC	CC	_	102	cc	_	_
117	partially	partially	RB	RB	_	118	advmod	_	_
118	restores	restore	VBZ	VBZ	_	102	conj	_	_
119	RA	ra	NN	NN	_	120	compound	_	_
120	response	response	NN	NN	_	118	dobj	_	_
121	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	17	nsubjpass	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	T-cell	t-cell	NN	NN	_	7	compound	_	_
5	antigen	antigen	NN	NN	_	7	compound	_	_
6	receptor-CD3	receptor-cd3	JJ	JJ	_	7	amod	_	_
7	complex	complex	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphatase	phosphatase	NN	NN	_	14	compound	_	_
14	inhibitor	inhibitor	NN	NN	_	1	nmod	_	_
15	pervanadate	pervanadate	NN	NN	_	14	dep	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	19	case	_	_
19	inhibition	inhibition	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CD45	cd45	NN	NN	_	19	nmod	_	_
22	:	:	:	:	_	17	punct	_	_
23	evidence	evidence	NN	NN	_	17	dep	_	_
24	for	for	IN	IN	_	27	case	_	_
25	two	two	CD	CD	_	27	nummod	_	_
26	interconnected	interconnected	JJ	JJ	_	27	amod	_	_
27	Lck/Fyn-	lck/fyn-	NN	NN	_	23	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	zap-70-dependent	zap-70-dependent	JJ	JJ	_	27	conj	_	_
30	signaling	signaling	NN	NN	_	31	compound	_	_
31	pathways	pathway	NNS	NNS	_	27	dep	_	_
32	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphatase	phosphatase	NN	NN	_	5	compound	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	inhibitor	inhibitor	NN	NN	_	10	nsubj	_	_
6	pervanadate	pervanadate	NN	NN	_	5	dep	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	potent	potent	JJ	JJ	_	10	amod	_	_
10	activator	activator	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	through	through	IN	IN	_	15	case	_	_
15	induction	induction	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	downstream	downstream	JJ	JJ	_	21	amod	_	_
21	events	event	NNS	NNS	_	15	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	activation	activation	NN	NN	_	25	compound	_	_
25	cascade	cascade	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	CD45-	cd45-	NN	NN	_	1	dobj	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	CD3-negative	cd3-negative	JJ	JJ	_	2	conj	_	_
5	variants	variant	NNS	NNS	_	2	dep	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	Jurkat	jurkat	NN	NN	_	11	compound	_	_
9	leukemic	leukemic	JJ	JJ	_	11	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	2	nmod	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	show	show	VBP	VBP	_	1	parataxis	_	_
14	that	that	IN	IN	_	22	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	different	different	JJ	JJ	_	18	amod	_	_
17	biochemical	biochemical	JJ	JJ	_	16	dep	_	_
18	events	event	NNS	NNS	_	22	nsubj	_	_
19	induced	induce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	pervanadate	pervanadate	NN	NN	_	19	nmod	_	_
22	appeared	appear	VBD	VBD	_	13	ccomp	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	dependent	dependent	JJ	JJ	_	22	xcomp	_	_
26	on	on	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	presence	presence	NN	NN	_	25	nmod	_	_
29	at	at	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	surface	surface	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	either	either	CC	CC	_	35	cc:preconj	_	_
35	CD45	cd45	NN	NN	_	28	nmod	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	CD3	cd3	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	1	punct	_	_

1	CD45-dependent	cd45-dependent	JJ	JJ	_	2	amod	_	_
2	events	event	NNS	NNS	_	44	nsubj	_	_
3	such	such	JJ	JJ	_	6	case	_	_
4	as	as	IN	IN	_	3	mwe	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Shc	shc	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	activation	activation	NN	NN	_	6	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor-kappa	factor-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	14	punct	_	_
20	activator	activator	NN	NN	_	21	compound	_	_
21	protein-1	protein-1	NN	NN	_	14	appos	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	AP-1	ap-1	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	14	punct	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	14	appos	_	_
28	,	,	,	,	_	6	punct	_	_
29	and	and	CC	CC	_	6	cc	_	_
30	stimulation	stimulation	NN	NN	_	6	conj	_	_
31	of	of	IN	IN	_	36	case	_	_
32	interleukin-2	interleukin-2	NN	NN	_	36	compound	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	IL-2	il-2	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	promoter	promoter	NN	NN	_	30	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	of	of	IN	IN	_	39	case	_	_
39	CD69	cd69	NN	NN	_	36	conj	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	CD25	cd25	NN	NN	_	39	conj	_	_
42	surface	surface	NN	NN	_	43	compound	_	_
43	expression	expression	NN	NN	_	39	dep	_	_
44	paralleled	parallel	VBD	VBD	_	0	root	_	_
45	activation	activation	NN	NN	_	44	dobj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	tyrosine	tyrosine	NN	NN	_	49	compound	_	_
49	kinases	kinase	NNS	NNS	_	45	nmod	_	_
50	lck	lck	NN	NN	_	49	dep	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	fyn	fyn	NN	NN	_	50	conj	_	_
53	.	.	.	.	_	44	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	calcium	calcium	NN	NN	_	7	compound	_	_
7	influx	influx	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	CD3-dependent	cd3-dependent	JJ	JJ	_	11	amod	_	_
11	event	event	NN	NN	_	4	appos	_	_
12	,	,	,	,	_	4	punct	_	_
13	paralleled	parallel	VBD	VBD	_	0	root	_	_
14	zap-70	zap-70	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	12	det	_	_
6	T-cell	t-cell	NN	NN	_	12	compound	_	_
7	antigen	antigen	NN	NN	_	12	compound	_	_
8	receptor-CD3	receptor-cd3	JJ	JJ	_	12	amod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	TcR-CD3	tcr-cd3	JJ	JJ	_	12	amod	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	complex	complex	NN	NN	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	functionally	functionally	RB	RB	_	15	advmod	_	_
15	linked	link	VBN	VBN	_	3	ccomp	_	_
16	to	to	TO	TO	_	25	case	_	_
17	two	two	CD	CD	_	25	nummod	_	_
18	different	different	JJ	JJ	_	25	amod	_	_
19	protein	protein	NN	NN	_	21	compound	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	kinase	kinase	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PTK	ptk	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	modules	module	NNS	NNS	_	15	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	separate	separate	JJ	JJ	_	29	amod	_	_
28	specific	specific	JJ	JJ	_	27	dep	_	_
29	functions	function	NNS	NNS	_	25	nmod	_	_
30	and	and	CC	CC	_	15	cc	_	_
31	that	that	IN	IN	_	37	mark	_	_
32	CD45	cd45	NN	NN	_	37	nsubj	_	_
33	may	may	MD	MD	_	37	aux	_	_
34	be	be	VB	VB	_	37	cop	_	_
35	an	a	DT	DT	_	37	det	_	_
36	important	important	JJ	JJ	_	37	amod	_	_
37	regulator	regulator	NN	NN	_	15	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	this	this	DT	DT	_	40	det	_	_
40	coupling	coupling	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	cAMP	camp	NN	NN	_	1	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	down-regulation	down-regulation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	two	two	CD	CD	_	17	nummod	_	_
14	parallel	parallel	JJ	JJ	_	17	amod	_	_
15	mitogen-activated	mitogen-activated	JJ	JJ	_	14	dep	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	11	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	the	the	DT	DT	_	23	dep	_	_
21	extracellular	extracellular	JJ	JJ	_	23	amod	_	_
22	signal-related	signal-related	JJ	JJ	_	23	amod	_	_
23	kinase	kinase	NN	NN	_	9	nsubjpass	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	c-Jun	c-jun	NN	NN	_	27	compound	_	_
26	N-terminal	n-terminal	JJ	JJ	_	27	amod	_	_
27	kinase	kinase	NN	NN	_	23	conj	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	2	nmod	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	signals	signal	NNS	NNS	_	7	dobj	_	_
9	from	from	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	TCR	tcr	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	a	a	DT	DT	_	15	det	_	_
14	co-receptor	co-receptor	NN	NN	_	15	compound	_	_
15	molecule	molecule	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	15	punct	_	_
17	such	such	JJ	JJ	_	19	case	_	_
18	as	as	IN	IN	_	17	mwe	_	_
19	CD28	cd28	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	activate	activate	VBP	VBP	_	8	acl:relcl	_	_
23	parallel	parallel	JJ	JJ	_	28	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	partially	partially	RB	RB	_	26	advmod	_	_
26	cross-reactive	cross-reactive	JJ	JJ	_	23	conj	_	_
27	signaling	signaling	NN	NN	_	28	compound	_	_
28	pathways	pathway	NNS	NNS	_	22	dobj	_	_
29	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	pathways	pathway	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	disrupted	disrupt	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	agonists	agonist	NNS	NNS	_	4	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	utilize	utilize	VBP	VBP	_	6	acl:relcl	_	_
9	adenylate	adenylate	NN	NN	_	10	compound	_	_
10	cyclase	cyclase	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cAMP-dependent	camp-dependent	JJ	JJ	_	15	amod	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	10	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PKA	pka	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	adenylate	adenylate	NN	NN	_	6	compound	_	_
6	cyclase	cyclase	NN	NN	_	7	compound	_	_
7	activator	activator	NN	NN	_	11	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	forskolin	forskolin	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
12	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	13	amod	_	_
13	shift	shift	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	Lck	lck	NN	NN	_	17	compound	_	_
16	electrophoretic	electrophoretic	JJ	JJ	_	17	amod	_	_
17	mobility	mobility	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
20	an	a	DT	DT	_	21	det	_	_
21	intervention	intervention	NN	NN	_	19	dobj	_	_
22	at	at	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	TCR-coupled	tcr-coupled	JJ	JJ	_	26	amod	_	_
25	phosphoinositide	phosphoinositide	JJ	JJ	_	26	amod	_	_
26	turnover	turnover	NN	NN	_	21	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	precedes	precede	VBZ	VBZ	_	26	acl:relcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	activation	activation	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	PKC	pkc	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	shift	shift	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Lck	lck	NN	NN	_	2	nmod	_	_
5	following	follow	VBG	VBG	_	2	acl	_	_
6	direct	direct	JJ	JJ	_	8	amod	_	_
7	PKC	pkc	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	by	by	IN	IN	_	12	case	_	_
10	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	12	compound	_	_
11	phorbol	phorbol	NN	NN	_	12	compound	_	_
12	13-acetate	13-acetate	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	bypasses	bypass	VBZ	VBZ	_	8	acl:relcl	_	_
16	early	early	JJ	JJ	_	19	amod	_	_
17	receptor-triggered	receptor-triggered	JJ	JJ	_	16	dep	_	_
18	biochemical	biochemical	JJ	JJ	_	16	dep	_	_
19	events	event	NNS	NNS	_	15	dobj	_	_
20	,	,	,	,	_	2	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	insensitive	insensitive	JJ	JJ	_	0	root	_	_
23	to	to	TO	TO	_	24	case	_	_
24	forskolin	forskolin	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	22	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	forskolin	forskolin	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	PKC	pkc	NN	NN	_	8	compound	_	_
7	downstream	downstream	JJ	JJ	_	8	amod	_	_
8	events	event	NNS	NNS	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	such	such	JJ	JJ	_	13	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	c-jun	c-jun	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	critical	critical	JJ	JJ	_	13	acl:relcl	_	_
18	for	for	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	activation	activation	NN	NN	_	21	compound	_	_
21	process	process	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	analyze	analyze	VB	VB	_	0	root	_	_
4	potential	potential	JJ	JJ	_	6	amod	_	_
5	cross	cross	NN	NN	_	6	compound	_	_
6	points	point	NNS	NNS	_	3	dobj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	positively	positively	RB	RB	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	negatively	negatively	RB	RB	_	8	conj	_	_
11	regulating	regulate	VBG	VBG	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	8	dep	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	6	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	tested	test	VBD	VBD	_	3	parataxis	_	_
20	the	the	DT	DT	_	21	det	_	_
21	effects	effect	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	activators	activator	NNS	NNS	_	21	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	adenylate	adenylate	NN	NN	_	27	compound	_	_
27	cyclase	cyclase	NN	NN	_	23	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	PKA	pka	NN	NN	_	27	conj	_	_
30	on	on	IN	IN	_	37	case	_	_
31	two	two	CD	CD	_	37	nummod	_	_
32	parallel	parallel	JJ	JJ	_	37	amod	_	_
33	mitogen-activated	mitogen-activated	JJ	JJ	_	32	dep	_	_
34	protein	protein	NN	NN	_	37	compound	_	_
35	kinase	kinase	NN	NN	_	37	compound	_	_
36	signaling	signaling	NN	NN	_	37	compound	_	_
37	pathways	pathway	NNS	NNS	_	21	nmod	_	_
38	mediated	mediate	VBN	VBN	_	37	acl	_	_
39	by	by	IN	IN	_	42	case	_	_
40	extracellular	extracellular	JJ	JJ	_	42	amod	_	_
41	signal-regulated	signal-regulated	JJ	JJ	_	42	amod	_	_
42	kinase	kinase	NN	NN	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	ERK	erk	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	and	and	CC	CC	_	42	cc	_	_
47	c-Jun	c-jun	NN	NN	_	49	compound	_	_
48	N-terminal	n-terminal	JJ	JJ	_	49	amod	_	_
49	kinase	kinase	NN	NN	_	42	conj	_	_
50	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	4	det	_	_
3	PKC-specific	pkc-specific	JJ	JJ	_	4	amod	_	_
4	inhibitor	inhibitor	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	GF109203X	gf109203x	NN	NN	_	4	appos	_	_
7	,	,	,	,	_	4	punct	_	_
8	or	or	CC	CC	_	4	cc	_	_
9	PKC-depleted	pkc-depleted	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	conj	_	_
12	,	,	,	,	_	1	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	found	find	VBD	VBD	_	1	parataxis	_	_
15	that	that	IN	IN	_	26	mark	_	_
16	a	a	DT	DT	_	18	det	_	_
17	large	large	JJ	JJ	_	18	amod	_	_
18	part	part	NN	NN	_	26	nsubj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	23	amod	_	_
22	ERK	erk	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	18	nmod	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	PKC	pkc	NN	NN	_	26	nmod:npmod	_	_
26	dependent	dependent	JJ	JJ	_	14	ccomp	_	_
27	.	.	.	.	_	1	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	PKC-dependent	pkc-dependent	JJ	JJ	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	-independent	-independent	JJ	JJ	_	2	conj	_	_
5	activation	activation	NN	NN	_	2	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ERK	erk	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	sensitive	sensitive	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	inhibition	inhibition	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	forskolin	forskolin	NN	NN	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	a	a	DT	DT	_	18	det	_	_
16	cell-permeable	cell-permeable	JJ	JJ	_	18	amod	_	_
17	cAMP	camp	NN	NN	_	18	compound	_	_
18	analogue	analogue	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	dbcAMP	dbcamp	NN	NN	_	18	appos	_	_
21	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	23	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	8	compound	_	_
7	phorbol	phorbol	NN	NN	_	8	compound	_	_
8	13-acetate	13-acetate	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	ionomycin	ionomycin	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	synergized	synergize	VBD	VBD	_	8	acl:relcl	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	fully	fully	RB	RB	_	16	advmod	_	_
16	activate	activate	VB	VB	_	13	xcomp	_	_
17	c-Jun	c-jun	NN	NN	_	19	compound	_	_
18	N-terminal	n-terminal	JJ	JJ	_	19	amod	_	_
19	kinase	kinase	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	4	punct	_	_
21	was	be	VBD	VBD	_	23	cop	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	sensitive	sensitive	JJ	JJ	_	0	root	_	_
24	to	to	TO	TO	_	25	case	_	_
25	inhibition	inhibition	NN	NN	_	23	nmod	_	_
26	by	by	IN	IN	_	27	case	_	_
27	forskolin	forskolin	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	PKA	pka	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	interfering	interfere	VBG	VBG	_	6	advcl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	multiple	multiple	JJ	JJ	_	14	amod	_	_
14	events	event	NNS	NNS	_	11	nmod	_	_
15	along	along	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	pathways	pathway	NNS	NNS	_	14	nmod	_	_
20	operating	operate	VBG	VBG	_	19	acl	_	_
21	downstream	downstream	RB	RB	_	20	advmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	TCR	tcr	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	29	det	_	_
27	CD28	cd28	NN	NN	_	29	compound	_	_
28	co-receptor	co-receptor	NN	NN	_	29	compound	_	_
29	molecules	molecule	NNS	NNS	_	24	conj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Quantitation	quantitation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	beta	beta	NN	NN	_	7	compound	_	_
4	1	1	CD	CD	_	7	nummod	_	_
5	triiodothyronine	triiodothyronine	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	tissues	tissue	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	17	case	_	_
12	competitive	competitive	JJ	JJ	_	17	amod	_	_
13	reverse	reverse	JJ	JJ	_	17	amod	_	_
14	transcription	transcription	NN	NN	_	17	compound	_	_
15	polymerase	polymerase	NN	NN	_	17	compound	_	_
16	chain	chain	NN	NN	_	17	compound	_	_
17	reaction	reaction	NN	NN	_	1	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Thyroid	thyroid	NN	NN	_	2	compound	_	_
2	hormones	hormone	NNS	NNS	_	3	nsubj	_	_
3	act	act	VBP	VBP	_	0	root	_	_
4	by	by	IN	IN	_	5	case	_	_
5	binding	bind	VBG	VBG	_	3	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	the	the	DT	DT	_	14	dep	_	_
12	thyroid	thyroid	NN	NN	_	14	compound	_	_
13	hormone	hormone	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	9	appos	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TR	tr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	alpha	alpha	NN	NN	_	14	dep	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	beta	beta	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Data	datum	NNS	NNS	_	8	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	culture	culture	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	animal	animal	NN	NN	_	4	conj	_	_
7	studies	study	NNS	NNS	_	4	dep	_	_
8	indicate	indicate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	TR	tr	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	14	nsubjpass	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	regulated	regulate	VBN	VBN	_	8	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	modulate	modulate	VB	VB	_	14	xcomp	_	_
17	target	target	NN	NN	_	19	compound	_	_
18	organ	organ	NN	NN	_	19	compound	_	_
19	responsiveness	responsiveness	NN	NN	_	16	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	thyroid	thyroid	NN	NN	_	22	compound	_	_
22	hormone	hormone	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	10	mark	_	_
4	such	such	JJ	JJ	_	6	amod	_	_
5	adaptive	adaptive	JJ	JJ	_	4	dep	_	_
6	changes	change	NNS	NNS	_	10	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	TR	tr	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	occur	occur	VBP	VBP	_	2	ccomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	humans	human	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	determined	determine	VBD	VBD	_	2	parataxis	_	_
16	the	the	DT	DT	_	18	det	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	15	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	hTR	htr	NN	NN	_	22	compound	_	_
22	beta	beta	NN	NN	_	18	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	various	various	JJ	JJ	_	27	amod	_	_
26	thyroid	thyroid	NN	NN	_	27	compound	_	_
27	states	state	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Patients	patient	NNS	NNS	_	8	nsubjpass	_	_
2	with	with	IN	IN	_	4	case	_	_
3	overt	overt	JJ	JJ	_	4	amod	_	_
4	hypo-	hypo-	JJ	JJ	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	hyperthyroidism	hyperthyroidism	NN	NN	_	4	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	enrolled	enrol	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	study	study	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	Total	total	JJ	JJ	_	2	amod	_	_
2	RNA	rna	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	isolated	isolate	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	9	case	_	_
6	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
7	blood	blood	NN	NN	_	9	compound	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	hTR	htr	NN	NN	_	14	compound	_	_
12	beta	beta	NN	NN	_	14	compound	_	_
13	1	1	CD	CD	_	14	nummod	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	16	nsubj	_	_
16	determined	determine	VBN	VBN	_	4	conj	_	_
17	by	by	IN	IN	_	22	case	_	_
18	quantitative	quantitative	JJ	JJ	_	22	amod	_	_
19	competitive	competitive	JJ	JJ	_	18	dep	_	_
20	reverse	reverse	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	PCR	pcr	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	comparison	comparison	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	hTR	htr	NN	NN	_	7	compound	_	_
5	beta	beta	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	10	nsubjpass	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	determined	determine	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	normal	normal	JJ	JJ	_	16	amod	_	_
15	thyroid	thyroid	NN	NN	_	16	compound	_	_
16	tissue	tissue	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	euthyroid	euthyroid	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	TR	tr	NN	NN	_	5	compound	_	_
3	beta	beta	NN	NN	_	5	compound	_	_
4	1	1	CD	CD	_	5	nummod	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	10	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	1.8	1.8	CD	CD	_	0	root	_	_
11	+/-	+/-	CC	CC	_	10	cc	_	_
12	0.4	0.4	CD	CD	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	1.9	1.9	CD	CD	_	10	appos	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	0.5	0.5	CD	CD	_	14	conj	_	_
17	,	,	,	,	_	10	punct	_	_
18	1.1	1.1	CD	CD	_	10	appos	_	_
19	+/-	+/-	CC	CC	_	18	cc	_	_
20	0.4	0.4	CD	CD	_	21	nummod	_	_
21	10(-18)	10(-18)	CD	CD	_	18	conj	_	_
22	mol/microgram	mol/microgram	NN	NN	_	23	compound	_	_
23	RNA	rna	NN	NN	_	10	dep	_	_
24	in	in	IN	IN	_	25	case	_	_
25	hypo-	hypo-	JJ	JJ	_	10	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	eu-	eu-	JJ	JJ	_	25	conj	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	hyperthyroid	hyperthyroid	JJ	JJ	_	25	conj	_	_
30	patients	patient	NNS	NNS	_	25	dep	_	_
31	,	,	,	,	_	10	punct	_	_
32	respectively	respectively	RB	RB	_	10	advmod	_	_
33	,	,	,	,	_	10	punct	_	_
34	corresponding	correspond	VBG	VBG	_	10	advcl	_	_
35	to	to	TO	TO	_	41	case	_	_
36	an	a	DT	DT	_	41	det	_	_
37	estimated	estimate	VBN	VBN	_	40	dep	_	_
38	0.5	0.5	CD	CD	_	40	compound	_	_
39	-	-	:	:	_	40	punct	_	_
40	2	2	CD	CD	_	41	nummod	_	_
41	molecules	molecule	NNS	NNS	_	34	nmod	_	_
42	per	per	IN	IN	_	43	case	_	_
43	cell	cell	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	8	det	_	_
3	mean	mean	JJ	JJ	_	8	amod	_	_
4	hTR	htr	NN	NN	_	7	compound	_	_
5	beta	beta	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	12	nsubj	_	_
9	were	be	VBD	VBD	_	12	cop	_	_
10	40	40	CD	CD	_	11	nummod	_	_
11	%	%	NN	NN	_	12	nmod:npmod	_	_
12	lower	lower	JJR	JJR	_	24	advcl	_	_
13	in	in	IN	IN	_	14	case	_	_
14	hyperthyroid	hyperthyroid	JJ	JJ	_	12	nmod	_	_
15	than	than	IN	IN	_	18	case	_	_
16	in	in	IN	IN	_	18	case	_	_
17	euthyroid	euthyroid	JJ	JJ	_	18	amod	_	_
18	subjects	subject	NNS	NNS	_	12	nmod	_	_
19	,	,	,	,	_	24	punct	_	_
20	this	this	DT	DT	_	21	det	_	_
21	difference	difference	NN	NN	_	24	nsubj	_	_
22	did	do	VBD	VBD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	reach	reach	VB	VB	_	0	root	_	_
25	statistical	statistical	JJ	JJ	_	26	amod	_	_
26	significance	significance	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	24	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	hTR	htr	NN	NN	_	7	compound	_	_
5	beta	beta	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	2	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	thyroid	thyroid	NN	NN	_	13	compound	_	_
13	gland	gland	NN	NN	_	10	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	euthyroid	euthyroid	JJ	JJ	_	16	amod	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	developed	develop	VBD	VBD	_	0	root	_	_
6	an	a	DT	DT	_	7	det	_	_
7	assay	assay	NN	NN	_	5	dobj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	quantitative	quantitative	JJ	JJ	_	11	amod	_	_
11	determination	determination	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	hTR	htr	NN	NN	_	16	compound	_	_
14	beta	beta	NN	NN	_	16	compound	_	_
15	1	1	CD	CD	_	16	nummod	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	11	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	small	small	JJ	JJ	_	22	amod	_	_
20	human	human	JJ	JJ	_	19	dep	_	_
21	tissue	tissue	NN	NN	_	22	compound	_	_
22	samples	sample	NNS	NNS	_	17	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	containing	contain	VBG	VBG	_	22	acl	_	_
25	as	as	RB	RB	_	28	advmod	_	_
26	little	little	JJ	JJ	_	28	advmod	_	_
27	as	as	IN	IN	_	28	advmod	_	_
28	50	50	CD	CD	_	29	nummod	_	_
29	ng	ng	NN	NN	_	24	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	total	total	JJ	JJ	_	32	amod	_	_
32	RNA	rna	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Absolute	absolute	JJ	JJ	_	6	amod	_	_
2	hTR	htr	NN	NN	_	5	compound	_	_
3	beta	beta	NN	NN	_	5	compound	_	_
4	1	1	CD	CD	_	5	nummod	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	9	nsubj	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	very	very	RB	RB	_	9	advmod	_	_
9	low	low	JJ	JJ	_	0	root	_	_
10	with	with	IN	IN	_	18	mark	_	_
11	an	a	DT	DT	_	14	det	_	_
12	estimated	estimate	VBN	VBN	_	13	dep	_	_
13	one	one	CD	CD	_	14	nummod	_	_
14	molecule	molecule	NN	NN	_	18	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	mRNA	mrna	NN	NN	_	14	nmod	_	_
17	being	be	VBG	VBG	_	18	cop	_	_
18	present	present	JJ	JJ	_	9	advcl	_	_
19	in	in	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
22	blood	blood	NN	NN	_	23	compound	_	_
23	cell	cell	NN	NN	_	18	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	thyrocyte	thyrocyte	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	9	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	up-regulation	up-regulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	hTR	htr	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	2	nmod	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	seen	see	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	hypothyroid	hypothyroid	JJ	JJ	_	8	nmod	_	_
11	relative	relative	JJ	JJ	_	8	advmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	euthyroid	euthyroid	JJ	JJ	_	14	amod	_	_
14	patients	patient	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	non-significant	non-significant	JJ	JJ	_	7	amod	_	_
7	trend	trend	NN	NN	_	4	nsubj	_	_
8	towards	towards	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	down-regulation	down-regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	hTR	htr	NN	NN	_	15	compound	_	_
13	beta	beta	NN	NN	_	15	compound	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	10	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	hyperthyroid	hyperthyroid	JJ	JJ	_	19	amod	_	_
19	patients	patient	NNS	NNS	_	7	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Interaction	interaction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HTLV-I	htlv-i	NN	NN	_	4	compound	_	_
4	Tax	tax	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	proteasome	proteasome	NN	NN	_	1	nmod	_	_
9	:	:	:	:	_	1	punct	_	_
10	implications	implication	NNS	NNS	_	1	dep	_	_
11	for	for	IN	IN	_	14	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	T-cell	t-cell	NN	NN	_	6	compound	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	14	nsubjpass	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	has	have	VBZ	VBZ	_	14	aux	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	etiologically	etiologically	RB	RB	_	14	advmod	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	adult	adult	JJ	JJ	_	22	amod	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	leukemia	leukemia	NN	NN	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	ATL	atl	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	as	as	RB	RB	_	22	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	degenerative	degenerative	JJ	JJ	_	31	amod	_	_
30	neurologic	neurologic	JJ	JJ	_	29	dep	_	_
31	syndrome	syndrome	NN	NN	_	22	conj	_	_
32	termed	term	VBN	VBN	_	31	acl	_	_
33	tropical	tropical	JJ	JJ	_	35	amod	_	_
34	spastic	spastic	JJ	JJ	_	35	amod	_	_
35	paraparesis	paraparesis	NN	NN	_	32	xcomp	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	TSP	tsp	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	14	punct	_	_

1	HTLV-I	htlv-i	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	transactivator	transactivator	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	dobj	_	_
7	termed	term	VBN	VBN	_	6	acl	_	_
8	Tax	tax	NN	NN	_	7	xcomp	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	appears	appear	VBZ	VBZ	_	6	acl:relcl	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	play	play	VB	VB	_	10	xcomp	_	_
13	an	a	DT	DT	_	15	det	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	process	process	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	immortalization	immortalization	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Even	even	RB	RB	_	12	advmod	_	_
2	though	though	IN	IN	_	12	mark	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	12	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	Tax	tax	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	4	acl:relcl	_	_
9	transformation	transformation	NN	NN	_	8	dobj	_	_
10	are	be	VBP	VBP	_	12	cop	_	_
11	still	still	RB	RB	_	12	advmod	_	_
12	unknown	unknown	JJ	JJ	_	15	dep	_	_
13	,	,	,	,	_	15	punct	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	seems	seem	VBZ	VBZ	_	0	root	_	_
16	likely	likely	JJ	JJ	_	15	xcomp	_	_
17	that	that	IN	IN	_	30	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ability	ability	NN	NN	_	30	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Tax	tax	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	alter	alter	VB	VB	_	19	acl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	many	many	JJ	JJ	_	29	amod	_	_
28	cellular	cellular	JJ	JJ	_	29	amod	_	_
29	genes	gene	NNS	NNS	_	25	nmod	_	_
30	plays	play	VBZ	VBZ	_	15	ccomp	_	_
31	an	a	DT	DT	_	33	det	_	_
32	important	important	JJ	JJ	_	33	amod	_	_
33	part	part	NN	NN	_	30	dobj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	process	process	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	Tax	tax	NN	NN	_	4	nsubj	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	bind	bind	VB	VB	_	0	root	_	_
5	directly	directly	RB	RB	_	7	advmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	DNA	dna	NN	NN	_	4	nmod	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	rather	rather	RB	RB	_	10	advmod	_	_
10	deregulates	deregulate	VBZ	VBZ	_	4	conj	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	family	family	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	host	host	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	whose	whose	WP$	WP$	_	8	nmod:poss	_	_
8	activity	activity	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	altered	alter	VBN	VBN	_	6	acl:relcl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	Tax	tax	NN	NN	_	10	nmod	_	_
13	includes	include	VBZ	VBZ	_	0	root	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B/Rel	b/rel	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	6	nsubjpass	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	post-transcriptionally	post-transcriptionally	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	assembly	assembly	NN	NN	_	6	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	second	second	JJ	JJ	_	13	amod	_	_
13	family	family	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	inhibitory	inhibitory	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	termed	term	VBN	VBN	_	13	acl	_	_
18	I	i	NN	NN	_	20	compound	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	xcomp	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	serve	serve	VBP	VBP	_	13	acl:relcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	sequester	sequester	VB	VB	_	22	xcomp	_	_
25	the	the	DT	DT	_	28	det	_	_
26	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
27	B/Rel	b/rel	NN	NN	_	28	compound	_	_
28	complexes	complex	NNS	NNS	_	24	dobj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	cytoplasm	cytoplasm	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	I	i	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	polyubiquitinated	polyubiquitinate	VBN	VBN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	degraded	degrade	VBN	VBN	_	10	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	proteasome	proteasome	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	proteolytic	proteolytic	JJ	JJ	_	3	amod	_	_
3	event	event	NN	NN	_	4	nsubj	_	_
4	liberates	liberate	VBZ	VBZ	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	4	dobj	_	_
7	,	,	,	,	_	4	punct	_	_
8	permitting	permit	VBG	VBG	_	4	advcl	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	rapid	rapid	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	8	dobj	_	_
12	into	into	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	nucleus	nucleus	NN	NN	_	11	nmod	_	_
15	where	where	WRB	WRB	_	17	advmod	_	_
16	it	it	PRP	PRP	_	17	nsubj	_	_
17	binds	bind	VBZ	VBZ	_	14	acl:relcl	_	_
18	to	to	TO	TO	_	22	case	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	cognate	cognate	JJ	JJ	_	22	amod	_	_
21	enhancer	enhancer	NN	NN	_	22	compound	_	_
22	elements	element	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Similarly	similarly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	p105	p105	NN	NN	_	5	compound	_	_
5	precursor	precursor	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	5	nmod	_	_
10	p50	p50	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	9	dep	_	_
12	is	be	VBZ	VBZ	_	15	auxpass	_	_
13	also	also	RB	RB	_	15	advmod	_	_
14	post-translationally	post-translationally	RB	RB	_	15	advmod	_	_
15	processed	process	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	proteasome	proteasome	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	9	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	Tax	tax	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	2	acl:relcl	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	6	dobj	_	_
9	remain	remain	VBP	VBP	_	0	root	_	_
10	unclear	unclear	JJ	JJ	_	9	xcomp	_	_
11	,	,	,	,	_	9	punct	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	findings	finding	NNS	NNS	_	20	nsubj	_	_
14	presented	present	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	literature	literature	NN	NN	_	14	nmod	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	often	often	RB	RB	_	20	advmod	_	_
20	controversial	controversial	JJ	JJ	_	9	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	physical	physical	JJ	JJ	_	5	amod	_	_
5	interaction	interaction	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HsN3	hsn3	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	7	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	proteasome	proteasome	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	raises	raise	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	intriguing	intriguing	JJ	JJ	_	5	amod	_	_
5	possibility	possibility	NN	NN	_	2	dobj	_	_
6	that	that	IN	IN	_	32	mark	_	_
7	physical	physical	JJ	JJ	_	8	amod	_	_
8	association	association	NN	NN	_	32	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	HsN3	hsn3	NN	NN	_	13	compound	_	_
12	proteasome	proteasome	NN	NN	_	13	compound	_	_
13	subunit	subunit	NN	NN	_	8	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	HTLV-I	htlv-i	NN	NN	_	16	compound	_	_
16	Tax	tax	NN	NN	_	8	nmod	_	_
17	coupled	couple	VBN	VBN	_	8	acl	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	independent	independent	JJ	JJ	_	21	amod	_	_
21	interaction	interaction	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Tax	tax	NN	NN	_	21	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	either	either	CC	CC	_	26	cc:preconj	_	_
26	p100	p100	NN	NN	_	21	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	p65-I	p65-i	NN	NN	_	31	compound	_	_
29	kappa	kappa	NN	NN	_	31	compound	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	26	conj	_	_
32	targets	target	VBZ	VBZ	_	5	ccomp	_	_
33	these	these	DT	DT	_	37	det	_	_
34	cytoplasmic	cytoplasmic	JJ	JJ	_	37	amod	_	_
35	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
36	B/Rel	b/rel	NN	NN	_	37	compound	_	_
37	complexes	complex	NNS	NNS	_	32	dobj	_	_
38	to	to	TO	TO	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	proteasome	proteasome	NN	NN	_	32	nmod	_	_
41	for	for	IN	IN	_	42	case	_	_
42	processing	processing	NN	NN	_	32	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	sialoadhesin	sialoadhesin	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	rat	rat	NN	NN	_	7	compound	_	_
7	macrophages	macrophage	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	enhancement	enhancement	NN	NN	_	1	conj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IFN-beta	ifn-beta	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	IL-4	il-4	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	lipopolysaccharide	lipopolysaccharide	NN	NN	_	7	conj	_	_
15	.	.	.	.	_	1	punct	_	_

1	Sialoadhesin	sialoadhesin	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	macrophage-restricted	macrophage-restricted	JJ	JJ	_	5	amod	_	_
5	member	member	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Ig	ig	NN	NN	_	9	compound	_	_
9	superfamily	superfamily	NN	NN	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	mediates	mediate	VBZ	VBZ	_	9	acl:relcl	_	_
12	adhesion	adhesion	NN	NN	_	11	dobj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	lymphoid	lymphoid	JJ	JJ	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	myeloid	myeloid	JJ	JJ	_	14	conj	_	_
17	cells	cell	NNS	NNS	_	14	dep	_	_
18	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subpopulation	subpopulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	macrophages	macrophage	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	tissues	tissue	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	in	in	IN	IN	_	15	case	_	_
14	chronic	chronic	JJ	JJ	_	15	amod	_	_
15	inflammation	inflammation	NN	NN	_	11	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	e.g.	e.g.	FW	FW	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	during	during	IN	IN	_	21	case	_	_
20	autoimmune	autoimmune	JJ	JJ	_	21	amod	_	_
21	diseases	disease	NNS	NNS	_	17	nmod	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	regulation	regulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	sialoadhesin	sialoadhesin	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	3	advmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	show	show	VBP	VBP	_	3	conj	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	18	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	GC	gc	NNS	NNS	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	induce	induce	VBP	VBP	_	12	ccomp	_	_
19	sialoadhesin	sialoadhesin	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	25	case	_	_
22	freshly	freshly	RB	RB	_	23	advmod	_	_
23	isolated	isolate	VBN	VBN	_	25	amod	_	_
24	rat	rat	NN	NN	_	25	compound	_	_
25	macrophages	macrophage	NNS	NNS	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	32	det	_	_
28	rat	rat	NN	NN	_	32	compound	_	_
29	macrophage	macrophage	NN	NN	_	32	compound	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	line	line	NN	NN	_	32	compound	_	_
32	R2	r2	NN	NN	_	25	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	22	nsubj	_	_
3	IFN-beta	ifn-beta	NN	NN	_	2	dep	_	_
4	,	,	,	,	_	3	punct	_	_
5	IFN-gamma	ifn-gamma	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	IL-4	il-4	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	LPS	lps	NN	NN	_	3	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	although	although	IN	IN	_	13	mark	_	_
13	unable	unable	JJ	JJ	_	22	dep	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	induce	induce	VB	VB	_	13	xcomp	_	_
16	sialoadhesin	sialoadhesin	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	themselves	themselves	PRP	PRP	_	15	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	were	be	VBD	VBD	_	22	cop	_	_
22	able	able	JJ	JJ	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	enhance	enhance	VB	VB	_	22	xcomp	_	_
25	GC-mediated	gc-mediated	JJ	JJ	_	26	amod	_	_
26	induction	induction	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	sialoadhesin	sialoadhesin	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	22	punct	_	_

1	Sialoadhesin	sialoadhesin	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	functional	functional	JJ	JJ	_	0	root	_	_
5	as	as	IN	IN	_	6	mark	_	_
6	shown	show	VBN	VBN	_	4	advcl	_	_
7	by	by	IN	IN	_	10	case	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	adhesion	adhesion	NN	NN	_	10	compound	_	_
10	assays	assay	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	RBCs	rbc	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blotting	blot	VBG	VBG	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	regulation	regulation	NN	NN	_	8	nsubj	_	_
7	predominantly	predominantly	RB	RB	_	8	advmod	_	_
8	occurred	occur	VBD	VBD	_	4	ccomp	_	_
9	at	at	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	level	level	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	different	different	JJ	JJ	_	5	amod	_	_
5	combinations	combination	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GC	gc	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cytokines/LPS	cytokines/lps	NNS	NNS	_	7	conj	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	differences	difference	NNS	NNS	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	level	level	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	GC-dependent	gc-dependent	JJ	JJ	_	17	amod	_	_
17	enhancement	enhancement	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	sialoadhesin	sialoadhesin	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	with	with	IN	IN	_	28	mark	_	_
23	IFN-beta	ifn-beta	NN	NN	_	28	nsubj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	IL-4	il-4	NN	NN	_	23	conj	_	_
26	being	be	VBG	VBG	_	28	cop	_	_
27	more	more	RBR	RBR	_	28	advmod	_	_
28	potent	potent	JJ	JJ	_	10	advcl	_	_
29	than	than	IN	IN	_	30	case	_	_
30	IFN-gamma	ifn-gamma	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	LPS	lps	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	LPS	lps	NN	NN	_	6	conj	_	_
9	could	could	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	reproduced	reproduce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	priming	priming	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	whereas	whereas	IN	IN	_	20	mark	_	_
16	IFN-beta	ifn-beta	NN	NN	_	20	nsubjpass	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-4	il-4	NN	NN	_	16	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	required	require	VBN	VBN	_	11	advcl	_	_
21	simultaneously	simultaneously	RB	RB	_	23	advmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	GC	gc	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	sialoadhesin	sialoadhesin	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	GC	gc	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	not	not	RB	RB	_	17	neg	_	_
15	by	by	IN	IN	_	17	case	_	_
16	mineralocorticoid	mineralocorticoid	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	7	punct	_	_
19	as	as	IN	IN	_	20	mark	_	_
20	shown	show	VBN	VBN	_	7	advcl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	inhibition	inhibition	NN	NN	_	23	compound	_	_
23	experiments	experiment	NNS	NNS	_	20	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	specific	specific	JJ	JJ	_	26	amod	_	_
26	antagonists	antagonist	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	21	mark	_	_
7	macrophages	macrophage	NNS	NNS	_	21	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	adrenal	adrenal	JJ	JJ	_	11	amod	_	_
11	gland	gland	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	major	major	JJ	JJ	_	15	amod	_	_
15	site	site	NN	NN	_	11	appos	_	_
16	of	of	IN	IN	_	19	case	_	_
17	endogenous	endogenous	JJ	JJ	_	19	amod	_	_
18	GC	gc	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	7	punct	_	_
21	express	express	VBP	VBP	_	5	ccomp	_	_
22	sialoadhesin	sialoadhesin	NN	NN	_	21	dobj	_	_
23	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	GC	gc	NN	NN	_	6	nsubj	_	_
6	act	act	VBP	VBP	_	3	ccomp	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	primary	primary	JJ	JJ	_	10	amod	_	_
10	inducer	inducer	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	sialoadhesin	sialoadhesin	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	rat	rat	NN	NN	_	16	compound	_	_
16	macrophages	macrophage	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	response	response	NN	NN	_	24	nsubjpass	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	enhanced	enhance	VBN	VBN	_	6	conj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	IFN-beta	ifn-beta	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell-derived	cell-derived	JJ	JJ	_	30	amod	_	_
30	cytokines	cytokine	NNS	NNS	_	26	conj	_	_
31	,	,	,	,	_	26	punct	_	_
32	or	or	CC	CC	_	26	cc	_	_
33	LPS	lps	NN	NN	_	26	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	Suppression	suppression	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
6	virus	virus	NN	NN	_	9	compound	_	_
7	long	long	JJ	JJ	_	9	amod	_	_
8	terminal	terminal	JJ	JJ	_	9	amod	_	_
9	repeat	repeat	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	CD8+	cd8+	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	1	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	0	root	_	_
16	on	on	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	NFAT-1	nfat-1	NN	NN	_	19	compound	_	_
19	element	element	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	CD8+	cd8+	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
6	infected	infected	JJ	JJ	_	7	amod	_	_
7	individuals	individual	NNS	NNS	_	3	nmod	_	_
8	produce	produce	VBP	VBP	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	soluble	soluble	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	8	dobj	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	efficiently	efficiently	RB	RB	_	14	advmod	_	_
14	suppresses	suppress	VBZ	VBZ	_	11	acl:relcl	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	14	dobj	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	response	response	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	HIV-1	hiv-1	NN	NN	_	6	nmod	_	_
10	long	long	JJ	JJ	_	12	amod	_	_
11	terminal	terminal	JJ	JJ	_	12	amod	_	_
12	repeat	repeat	NN	NN	_	9	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LTR	ltr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	to	to	TO	TO	_	17	case	_	_
17	mitogenic	mitogenic	JJ	JJ	_	6	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	Tat-mediated	tat-mediated	JJ	JJ	_	17	conj	_	_
20	activation	activation	NN	NN	_	17	dep	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	sensitive	sensitive	JJ	JJ	_	2	ccomp	_	_
23	to	to	TO	TO	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	suppressive	suppressive	JJ	JJ	_	26	amod	_	_
26	action	action	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	38	case	_	_
28	a	a	DT	DT	_	38	det	_	_
29	Herpesvirus	herpesvirus	NN	NN	_	38	compound	_	_
30	saimiri	saimiri	NN	NN	_	38	compound	_	_
31	(	(	-LRB-	-LRB-	_	38	punct	_	_
32	HVS	hvs	NN	NN	_	38	compound	_	_
33	)	)	-RRB-	-RRB-	_	38	punct	_	_
34	-transformed	-transformed	JJ	JJ	_	38	amod	_	_
35	CD8+	cd8+	JJ	JJ	_	38	amod	_	_
36	T	t	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	clone	clone	NN	NN	_	26	nmod	_	_
39	from	from	IN	IN	_	42	case	_	_
40	an	a	DT	DT	_	42	det	_	_
41	HIV-infected	hiv-infected	JJ	JJ	_	42	amod	_	_
42	individual	individual	JJ	JJ	_	38	nmod	_	_
43	and	and	CC	CC	_	38	cc	_	_
44	supernatants	supernatant	NNS	NNS	_	38	conj	_	_
45	from	from	IN	IN	_	48	case	_	_
46	CD8+	cd8+	JJ	JJ	_	48	amod	_	_
47	T	t	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	44	nmod	_	_
49	of	of	IN	IN	_	52	case	_	_
50	HIV-1-infected	hiv-1-infected	JJ	JJ	_	52	amod	_	_
51	asymptomatic	asymptomatic	JJ	JJ	_	50	dep	_	_
52	subjects	subject	NNS	NNS	_	48	nmod	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	CD4+	cd4+	JJ	JJ	_	44	dep	_	_
55	&gt;	&gt;	JJR	JJR	_	54	amod	_	_
56	350/microliters	350/microliters	NNS	NNS	_	55	dep	_	_
57	)	)	-RRB-	-RRB-	_	54	punct	_	_
58	.	.	.	.	_	2	punct	_	_

1	Mutagenesis	mutagenesis	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF	nf	NN	NN	_	5	compound	_	_
4	kappa	kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	Sp-1	sp-1	NN	NN	_	5	conj	_	_
8	elements	element	NNS	NNS	_	5	dep	_	_
9	within	within	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	LTR	ltr	NN	NN	_	5	nmod	_	_
12	resulted	result	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	no	no	DT	DT	_	15	neg	_	_
15	change	change	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	ability	ability	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	CD8+	cd8+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	supernatants	supernatant	NNS	NNS	_	18	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	inhibit	inhibit	VB	VB	_	18	acl	_	_
26	Tat-	tat-	NN	NN	_	25	dobj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	mitogen-mediated	mitogen-mediated	JJ	JJ	_	26	conj	_	_
29	LTR	ltr	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	26	dep	_	_
31	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	response	response	NN	NN	_	24	nsubj	_	_
5	to	to	TO	TO	_	7	case	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	Tat	tat	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	LTR	ltr	NN	NN	_	4	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	23	nmod	_	_
13	the	the	DT	DT	_	21	det	_	_
14	interleukin	interleukin	NN	NN	_	21	compound	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	IL	il	NN	NN	_	21	compound	_	_
17	)	)	-RRB-	-RRB-	_	21	punct	_	_
18	-2	-2	CD	CD	_	21	nummod	_	_
19	homology	homology	NN	NN	_	21	compound	_	_
20	NFAT-1	nfat-1	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	mutated	mutate	VBN	VBN	_	4	acl:relcl	_	_
24	resulted	result	VBD	VBD	_	0	root	_	_
25	in	in	IN	IN	_	28	case	_	_
26	almost	almost	RB	RB	_	27	advmod	_	_
27	complete	complete	JJ	JJ	_	28	amod	_	_
28	elimination	elimination	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	suppression	suppression	NN	NN	_	28	nmod	_	_
31	by	by	IN	IN	_	34	case	_	_
32	CD8+	cd8+	JJ	JJ	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	24	punct	_	_

1	This	this	DT	DT	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	when	when	WRB	WRB	_	11	advmod	_	_
6	the	the	DT	DT	_	9	det	_	_
7	NFAT-1	nfat-1	NN	NN	_	9	compound	_	_
8	mutant	mutant	JJ	JJ	_	9	amod	_	_
9	LTR	ltr	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	activated	activate	VBN	VBN	_	4	advcl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	mitogen	mitogen	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	17	nsubjpass	_	_
8	directed	direct	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	HIV-1	hiv-1	NN	NN	_	8	nmod	_	_
12	NF	nf	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	elements	element	NNS	NNS	_	11	dep	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	inhibited	inhibit	VBN	VBN	_	4	ccomp	_	_
18	by	by	IN	IN	_	21	case	_	_
19	CD8+	cd8+	JJ	JJ	_	21	amod	_	_
20	cell-derived	cell-derived	JJ	JJ	_	21	amod	_	_
21	supernatants	supernatant	NNS	NNS	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	Copeland	Copeland	NNP	NNP	_	4	dep	_	_
24	et	et	FW	FW	_	23	compound	_	_
25	al.	al.	FW	FW	_	23	dep	_	_
26	,	,	,	,	_	23	punct	_	_
27	AIDS	AIDS	NNP	NNP	_	30	compound	_	_
28	Res	Res	NNP	NNP	_	30	compound	_	_
29	Hum	Hum	NNP	NNP	_	30	compound	_	_
30	Retroviruses	Retroviruses	NNP	NNP	_	23	appos	_	_
31	,	,	,	,	_	23	punct	_	_
32	1995	1995	CD	CD	_	23	amod	_	_
33	;	;	:	:	_	23	punct	_	_
34	11	11	CD	CD	_	23	dep	_	_
35	:	:	:	:	_	23	punct	_	_
36	1321-1326	1321-1326	CD	CD	_	23	dep	_	_
37	)	)	-RRB-	-RRB-	_	23	punct	_	_
38	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	observations	observation	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	21	mark	_	_
8	mitogenic	mitogenic	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	21	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	mediated	mediate	VBN	VBN	_	9	acl	_	_
12	primarily	primarily	RB	RB	_	18	advmod	_	_
13	through	through	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	NF	nf	NN	NN	_	18	compound	_	_
16	kappa	kappa	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	enhancer	enhancer	NN	NN	_	11	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	susceptible	susceptible	JJ	JJ	_	6	ccomp	_	_
22	to	to	TO	TO	_	24	case	_	_
23	CD8-mediated	cd8-mediated	JJ	JJ	_	24	amod	_	_
24	inhibition	inhibition	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	however	however	RB	RB	_	21	advmod	_	_
27	,	,	,	,	_	21	punct	_	_
28	inhibition	inhibition	NN	NN	_	33	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	Tat-mediated	tat-mediated	JJ	JJ	_	31	amod	_	_
31	activation	activation	NN	NN	_	28	nmod	_	_
32	may	may	MD	MD	_	33	aux	_	_
33	rely	rely	VB	VB	_	21	parataxis	_	_
34	upon	upon	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	different	different	JJ	JJ	_	37	amod	_	_
37	pathway	pathway	NN	NN	_	33	nmod	_	_
38	that	that	WDT	WDT	_	41	nsubj	_	_
39	is	be	VBZ	VBZ	_	41	cop	_	_
40	NFAT-1	nfat-1	NN	NN	_	41	nmod:npmod	_	_
41	dependent	dependent	JJ	JJ	_	37	acl:relcl	_	_
42	.	.	.	.	_	1	punct	_	_

1	Induction	induction	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	activator	activator	NN	NN	_	6	compound	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	AP	ap	NN	NN	_	1	nmod	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	-1	-1	CD	CD	_	6	nummod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	factor-kappaB	factor-kappab	NN	NN	_	6	conj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	CD28	cd28	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	1	nmod	_	_
15	involves	involve	VBZ	VBZ	_	0	root	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	phosphatidylinositol	phosphatidylinositol	NN	NN	_	18	compound	_	_
18	3-kinase	3-kinase	NN	NN	_	15	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	acidic	acidic	JJ	JJ	_	21	amod	_	_
21	sphingomyelinase	sphingomyelinase	NN	NN	_	18	conj	_	_
22	signals	signal	NNS	NNS	_	18	dep	_	_
23	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	obstacle	obstacle	NN	NN	_	14	nsubj	_	_
4	in	in	IN	IN	_	5	mark	_	_
5	understanding	understand	VBG	VBG	_	3	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	events	event	NNS	NNS	_	5	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	follow	follow	VBP	VBP	_	8	acl:relcl	_	_
11	CD28	cd28	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	ligation	ligation	NN	NN	_	10	dobj	_	_
14	arises	arise	VBZ	VBZ	_	0	root	_	_
15	from	from	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	fact	fact	NN	NN	_	14	nmod	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	CD28	cd28	NN	NN	_	20	nsubj	_	_
20	acts	act	VBZ	VBZ	_	17	ccomp	_	_
21	as	as	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	costimulus	costimulus	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	TCR	tcr	NN	NN	_	26	compound	_	_
26	engagement	engagement	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	making	make	VBG	VBG	_	20	xcomp	_	_
29	it	it	PRP	PRP	_	32	nsubj	_	_
30	difficult	difficult	JJ	JJ	_	32	dep	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	assess	assess	VB	VB	_	28	xcomp	_	_
33	the	the	DT	DT	_	35	det	_	_
34	relative	relative	JJ	JJ	_	35	amod	_	_
35	contribution	contribution	NN	NN	_	32	dobj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	CD28	cd28	NN	NN	_	38	compound	_	_
38	signals	signal	NNS	NNS	_	35	nmod	_	_
39	as	as	IN	IN	_	40	case	_	_
40	distinct	distinct	JJ	JJ	_	32	advcl	_	_
41	from	from	IN	IN	_	42	case	_	_
42	those	those	DT	DT	_	40	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	TCR	tcr	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	overcome	overcome	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	problem	problem	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	exploited	exploit	VBN	VBN	_	2	parataxis	_	_
9	the	the	DT	DT	_	10	det	_	_
10	observation	observation	NN	NN	_	8	dobj	_	_
11	that	that	IN	IN	_	19	mark	_	_
12	activated	activate	VBN	VBN	_	16	amod	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	blasts	blast	NNS	NNS	_	19	nsubjpass	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	stimulated	stimulate	VBN	VBN	_	10	ccomp	_	_
20	via	via	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	CD28	cd28	NN	NN	_	24	compound	_	_
23	surface	surface	NN	NN	_	24	compound	_	_
24	molecule	molecule	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	absence	absence	NN	NN	_	19	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	antigenic	antigenic	JJ	JJ	_	30	amod	_	_
30	challenge	challenge	NN	NN	_	27	nmod	_	_
31	;	;	:	:	_	2	punct	_	_
32	thus	thus	RB	RB	_	2	advmod	_	_
33	,	,	,	,	_	2	punct	_	_
34	we	we	PRP	PRP	_	37	nsubj	_	_
35	have	have	VBP	VBP	_	37	aux	_	_
36	been	be	VBN	VBN	_	37	cop	_	_
37	able	able	JJ	JJ	_	2	dep	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	observe	observe	VB	VB	_	37	xcomp	_	_
40	the	the	DT	DT	_	41	det	_	_
41	response	response	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	normal	normal	JJ	JJ	_	45	amod	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	41	nmod	_	_
46	to	to	TO	TO	_	48	case	_	_
47	CD28	cd28	NN	NN	_	48	compound	_	_
48	activation	activation	NN	NN	_	41	nmod	_	_
49	in	in	IN	IN	_	50	case	_	_
50	isolation	isolation	NN	NN	_	39	nmod	_	_
51	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	this	this	DT	DT	_	3	det	_	_
3	system	system	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	1	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	observed	observe	VBD	VBD	_	1	parataxis	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	CD28	cd28	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	14	nsubj	_	_
10	by	by	IN	IN	_	13	case	_	_
11	B7-transfected	b7-transfected	JJ	JJ	_	13	amod	_	_
12	CHO	cho	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	induced	induce	VBD	VBD	_	6	ccomp	_	_
15	a	a	DT	DT	_	17	det	_	_
16	proliferative	proliferative	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	that	that	WDT	WDT	_	24	nsubjpass	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	accompanied	accompany	VBN	VBN	_	17	acl:relcl	_	_
25	by	by	IN	IN	_	28	case	_	_
26	measurable	measurable	JJ	JJ	_	28	amod	_	_
27	IL-2	il-2	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	1	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	subsequent	subsequent	JJ	JJ	_	4	amod	_	_
4	analysis	analysis	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	generation	generation	NN	NN	_	4	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	B7	b7	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
13	induced	induce	VBD	VBD	_	9	ccomp	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	activator	activator	NN	NN	_	16	compound	_	_
16	protein-1	protein-1	NN	NN	_	13	dobj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	AP-1	ap-1	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
22	factor-kappaB	factor-kappab	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
25	)	)	-RRB-	-RRB-	_	26	punct	_	_
26	complexes	complex	NNS	NNS	_	16	conj	_	_
27	,	,	,	,	_	16	punct	_	_
28	but	but	CC	CC	_	29	cc	_	_
29	not	not	RB	RB	_	16	cc	_	_
30	NF-AT	nf-at	NN	NN	_	16	conj	_	_
31	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	engagement	engagement	NN	NN	_	20	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	TCR	tcr	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	II	ii	CD	CD	_	11	nummod	_	_
11	MHC/superantigen	mhc/superantigen	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	either	either	CC	CC	_	18	cc:preconj	_	_
14	with	with	IN	IN	_	18	nmod	_	_
15	or	or	CC	CC	_	18	cc	_	_
16	without	without	IN	IN	_	18	conj	_	_
17	CD28	cd28	NN	NN	_	18	compound	_	_
18	ligation	ligation	NN	NN	_	4	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	resulted	result	VBD	VBD	_	0	root	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	induction	induction	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	NF-AT	nf-at	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	AP-1	ap-1	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	25	conj	_	_
31	as	as	RB	RB	_	23	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	IL-2	il-2	NN	NN	_	35	compound	_	_
35	production	production	NN	NN	_	23	conj	_	_
36	.	.	.	.	_	20	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	selective	selective	JJ	JJ	_	3	amod	_	_
3	inhibitors	inhibitor	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	1	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	1	parataxis	_	_
7	the	the	DT	DT	_	9	det	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	6	dobj	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD28-mediated	cd28-mediated	JJ	JJ	_	14	amod	_	_
14	induction	induction	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	AP-1	ap-1	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	revealed	reveal	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	generation	generation	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	sensitive	sensitive	JJ	JJ	_	2	ccomp	_	_
8	to	to	TO	TO	_	9	case	_	_
9	chloroquine	chloroquine	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	an	a	DT	DT	_	12	det	_	_
12	inhibitor	inhibitor	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	15	case	_	_
14	acidic	acidic	JJ	JJ	_	15	amod	_	_
15	sphingomyelinase	sphingomyelinase	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	but	but	CC	CC	_	9	cc	_	_
18	not	not	RB	RB	_	23	neg	_	_
19	to	to	TO	TO	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	phosphatidylinositol	phosphatidylinositol	NN	NN	_	22	compound	_	_
22	3-kinase	3-kinase	NN	NN	_	23	compound	_	_
23	inhibitor	inhibitor	NN	NN	_	9	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	wortmannin	wortmannin	NN	NN	_	23	appos	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	AP-1	ap-1	NN	NN	_	5	compound	_	_
5	generation	generation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	wortmannin	wortmannin	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	was	be	VBD	VBD	_	14	cop	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	variably	variably	RB	RB	_	14	advmod	_	_
14	sensitive	sensitive	JJ	JJ	_	7	conj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	chloroquine	chloroquine	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	activated	activate	VBN	VBN	_	14	advcl	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	dobj	_	_
10	,	,	,	,	_	14	punct	_	_
11	CD28-derived	cd28-derived	JJ	JJ	_	12	amod	_	_
12	signals	signal	NNS	NNS	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	stimulate	stimulate	VB	VB	_	3	ccomp	_	_
15	proliferation	proliferation	NN	NN	_	14	dobj	_	_
16	at	at	IN	IN	_	19	advmod	_	_
17	least	least	JJS	JJS	_	16	mwe	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	14	nmod	_	_
20	via	via	IN	IN	_	21	case	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	14	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	AP-1	ap-1	NN	NN	_	21	conj	_	_
24	generation	generation	NN	NN	_	21	dep	_	_
25	,	,	,	,	_	14	punct	_	_
26	and	and	CC	CC	_	14	cc	_	_
27	that	that	IN	IN	_	30	mark	_	_
28	this	this	DT	DT	_	29	det	_	_
29	response	response	NN	NN	_	30	nsubj	_	_
30	uses	use	VBZ	VBZ	_	14	conj	_	_
31	both	both	CC	CC	_	33	cc:preconj	_	_
32	acidic	acidic	JJ	JJ	_	33	amod	_	_
33	sphingomyelinase	sphingomyelinase	NN	NN	_	30	dobj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	phosphatidylinositol	phosphatidylinositol	NN	NN	_	37	compound	_	_
36	3-kinase-linked	3-kinase-linked	JJ	JJ	_	37	amod	_	_
37	pathways	pathway	NNS	NNS	_	33	conj	_	_
38	.	.	.	.	_	3	punct	_	_

1	Ras-dependent	ras-dependent	JJ	JJ	_	4	amod	_	_
2	,	,	,	,	_	1	punct	_	_
3	Ca2+-stimulated	ca2+-stimulated	JJ	JJ	_	1	dep	_	_
4	activation	activation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	11	case	_	_
6	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
7	factor	factor	NN	NN	_	11	compound	_	_
8	of	of	IN	IN	_	11	amod	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	by	by	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	constitutively	constitutively	RB	RB	_	15	advmod	_	_
15	active	active	JJ	JJ	_	17	amod	_	_
16	Cbl	cbl	NN	NN	_	17	compound	_	_
17	mutant	mutant	NN	NN	_	4	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TCR	tcr	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	rapid	rapid	JJ	JJ	_	11	amod	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	phosphorylation	phosphorylation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	proteins	protein	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	17	case	_	_
17	Cbl	cbl	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	protooncogene	protooncogene	NN	NN	_	21	compound	_	_
21	product	product	NN	NN	_	17	appos	_	_
22	whose	whose	WP$	WP$	_	23	nmod:poss	_	_
23	function	function	NN	NN	_	24	nsubj	_	_
24	remains	remain	VBZ	VBZ	_	21	acl:relcl	_	_
25	unclear	unclear	JJ	JJ	_	24	xcomp	_	_
26	.	.	.	.	_	8	punct	_	_

1	As	as	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	step	step	NN	NN	_	16	nmod	_	_
5	toward	toward	IN	IN	_	6	mark	_	_
6	elucidating	elucidate	VBG	VBG	_	4	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	function	function	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Cbl	cbl	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	TCR-initiated	tcr-initiated	JJ	JJ	_	13	amod	_	_
13	signaling	signaling	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	evaluated	evaluate	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	ability	ability	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	wild-type	wild-type	JJ	JJ	_	21	amod	_	_
21	Cbl	cbl	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	26	det	_	_
24	transforming	transform	VBG	VBG	_	26	amod	_	_
25	Cbl	cbl	NN	NN	_	26	compound	_	_
26	mutant	mutant	NN	NN	_	21	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	70Z/3	70z/3	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	induce	induce	VB	VB	_	18	acl	_	_
32	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
33	activation	activation	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	45	case	_	_
35	a	a	DT	DT	_	45	det	_	_
36	nuclear	nuclear	JJ	JJ	_	45	amod	_	_
37	factor	factor	NN	NN	_	45	compound	_	_
38	of	of	IN	IN	_	45	amod	_	_
39	activated	activate	VBN	VBN	_	45	amod	_	_
40	T	t	NN	NN	_	45	compound	_	_
41	cells	cell	NNS	NNS	_	45	compound	_	_
42	(	(	-LRB-	-LRB-	_	45	punct	_	_
43	NFAT	nfat	NN	NN	_	45	compound	_	_
44	)	)	-RRB-	-RRB-	_	45	punct	_	_
45	element	element	NN	NN	_	33	nmod	_	_
46	derived	derive	VBN	VBN	_	45	acl	_	_
47	from	from	IN	IN	_	54	case	_	_
48	the	the	DT	DT	_	54	det	_	_
49	interleukin	interleukin	NN	NN	_	54	compound	_	_
50	2	2	CD	CD	_	54	nummod	_	_
51	(	(	-LRB-	-LRB-	_	54	punct	_	_
52	IL2	il2	NN	NN	_	54	compound	_	_
53	)	)	-RRB-	-RRB-	_	54	punct	_	_
54	promoter	promoter	NN	NN	_	46	nmod	_	_
55	in	in	IN	IN	_	60	case	_	_
56	transiently	transiently	RB	RB	_	57	advmod	_	_
57	cotransfected	cotransfect	VBN	VBN	_	60	amod	_	_
58	Jurkat-TAg	jurkat-tag	NN	NN	_	60	compound	_	_
59	T	t	NN	NN	_	60	compound	_	_
60	cells	cell	NNS	NNS	_	54	nmod	_	_
61	.	.	.	.	_	16	punct	_	_

1	70Z/3	70z/3	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	but	but	CC	CC	_	4	cc	_	_
4	not	not	RB	RB	_	1	cc	_	_
5	Cbl	cbl	NN	NN	_	1	conj	_	_
6	,	,	,	,	_	1	punct	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	NFAT	nfat	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	enhanced	enhance	VBN	VBN	_	9	acl:relcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	calcium	calcium	NN	NN	_	18	compound	_	_
18	ionophore	ionophore	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	drastically	drastically	RB	RB	_	23	advmod	_	_
23	reduced	reduce	VBN	VBN	_	13	conj	_	_
24	by	by	IN	IN	_	27	case	_	_
25	cyclosporin	cyclosporin	NN	NN	_	27	compound	_	_
26	A	a	NN	NN	_	27	compound	_	_
27	pretreatment	pretreatment	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	point	point	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	21	nsubj	_	_
4	of	of	IN	IN	_	13	case	_	_
5	a	a	DT	DT	_	13	det	_	_
6	potential	potential	JJ	JJ	_	13	amod	_	_
7	phosphatidylinositol	phosphatidylinositol	NN	NN	_	13	compound	_	_
8	3-kinase	3-kinase	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	PI3-K	pi3-k	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	3	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Y731EAM	y731eam	NN	NN	_	13	dep	_	_
16	to	to	TO	TO	_	17	case	_	_
17	Y731EAC	y731eac	NN	NN	_	15	nmod	_	_
18	)	)	-RRB-	-RRB-	_	15	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	70Z/3	70z/3	NN	NN	_	3	nmod	_	_
21	disrupted	disrupt	VBD	VBD	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	association	association	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	PI3-K	pi3-k	NN	NN	_	23	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	70Z/3	70z/3	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	21	punct	_	_
29	but	but	CC	CC	_	21	cc	_	_
30	did	do	VBD	VBD	_	32	aux	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	reduce	reduce	VB	VB	_	21	conj	_	_
33	the	the	DT	DT	_	34	det	_	_
34	induction	induction	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	NFAT	nfat	NN	NN	_	37	compound	_	_
37	activity	activity	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	21	punct	_	_
39	suggesting	suggest	VBG	VBG	_	21	advcl	_	_
40	that	that	IN	IN	_	49	mark	_	_
41	the	the	DT	DT	_	42	det	_	_
42	interaction	interaction	NN	NN	_	49	nsubjpass	_	_
43	between	between	IN	IN	_	44	case	_	_
44	Cbl	cbl	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	PI3-K	pi3-k	NN	NN	_	44	conj	_	_
47	is	be	VBZ	VBZ	_	49	auxpass	_	_
48	not	not	RB	RB	_	49	neg	_	_
49	required	require	VBN	VBN	_	39	ccomp	_	_
50	in	in	IN	IN	_	53	case	_	_
51	the	the	DT	DT	_	53	det	_	_
52	70Z/3-mediated	70z/3-mediated	JJ	JJ	_	53	amod	_	_
53	induction	induction	NN	NN	_	49	nmod	_	_
54	of	of	IN	IN	_	55	case	_	_
55	NFAT	nfat	NN	NN	_	53	nmod	_	_
56	.	.	.	.	_	21	punct	_	_

1	Additional	additional	JJ	JJ	_	3	amod	_	_
2	mapping	mapping	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	defined	define	VBN	VBN	_	7	amod	_	_
7	deletions	deletion	NNS	NNS	_	12	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	C-terminal	c-terminal	JJ	JJ	_	11	amod	_	_
10	70Z/3	70z/3	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	7	nmod	_	_
12	affected	affect	VBD	VBD	_	4	ccomp	_	_
13	to	to	TO	TO	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	variable	variable	JJ	JJ	_	16	amod	_	_
16	degree	degree	NN	NN	_	12	nmod	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	ability	ability	NN	NN	_	12	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	stimulate	stimulate	VB	VB	_	18	acl	_	_
21	NFAT	nfat	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Strikingly	strikingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	deletion	deletion	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	346	346	CD	CD	_	7	nummod	_	_
6	C-terminal	c-terminal	JJ	JJ	_	7	amod	_	_
7	residues	residue	NNS	NNS	_	3	nmod	_	_
8	augmented	augment	VBD	VBD	_	0	root	_	_
9	this	this	DT	DT	_	10	det	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	8	punct	_	_
12	whereas	whereas	IN	IN	_	18	mark	_	_
13	removal	removal	NN	NN	_	18	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	20	20	CD	CD	_	17	nummod	_	_
16	additional	additional	JJ	JJ	_	17	amod	_	_
17	residues	residue	NNS	NNS	_	13	nmod	_	_
18	abolished	abolish	VBD	VBD	_	8	advcl	_	_
19	it	it	PRP	PRP	_	18	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	Coexpression	coexpression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	dominant	dominant	JJ	JJ	_	5	amod	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	Ras	ras	NN	NN	_	1	nmod	_	_
6	abrogated	abrogate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	14	det	_	_
8	basal	basal	JJ	JJ	_	14	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	ionomycin-stimulated	ionomycin-stimulated	JJ	JJ	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	70Z/3-mediated	70z/3-mediated	JJ	JJ	_	8	dep	_	_
13	NFAT	nfat	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	6	dobj	_	_
15	,	,	,	,	_	6	punct	_	_
16	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	functional	functional	JJ	JJ	_	19	amod	_	_
19	Ras	ras	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	16	ccomp	_	_
22	for	for	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	Cbl	cbl	NN	NN	_	3	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	Ras-dependent	ras-dependent	JJ	JJ	_	8	amod	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	pathways	pathway	NNS	NNS	_	3	nmod	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	lead	lead	VBP	VBP	_	8	acl:relcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	NFAT	nfat	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Generation	generation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	cytotoxic	cytotoxic	JJ	JJ	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
6	against	against	IN	IN	_	8	case	_	_
7	immunorecessive	immunorecessive	JJ	JJ	_	8	amod	_	_
8	epitopes	epitope	NNS	NNS	_	1	nmod	_	_
9	after	after	IN	IN	_	11	case	_	_
10	multiple	multiple	JJ	JJ	_	11	amod	_	_
11	immunizations	immunization	NNS	NNS	_	1	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	adenovirus	adenovirus	NN	NN	_	14	compound	_	_
14	vectors	vector	NNS	NNS	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	dependent	dependent	JJ	JJ	_	0	root	_	_
17	on	on	IN	IN	_	18	case	_	_
18	haplotype	haplotype	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	16	punct	_	_

1	Currently	currently	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	adenovirus	adenovirus	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	Ad	ad	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	9	aux	_	_
8	being	be	VBG	VBG	_	9	auxpass	_	_
9	considered	consider	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	vector	vector	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	cystic	cystic	JJ	JJ	_	18	amod	_	_
18	fibrosis	fibrosis	NN	NN	_	15	nmod	_	_
19	as	as	RB	RB	_	18	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	diseases	disease	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	10	det	_	_
4	cytotoxic	cytotoxic	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	CTL	ctl	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	response	response	NN	NN	_	14	nsubj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	Ad	ad	NN	NN	_	10	nmod	_	_
13	could	could	MD	MD	_	14	aux	_	_
14	limit	limit	VB	VB	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	effectiveness	effectiveness	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	such	such	JJ	JJ	_	19	amod	_	_
19	approaches	approach	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	Since	since	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	CTL	ctl	NN	NN	_	4	compound	_	_
4	response	response	NN	NN	_	10	nsubjpass	_	_
5	to	to	TO	TO	_	7	case	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	often	often	RB	RB	_	10	advmod	_	_
10	focused	focus	VBN	VBN	_	25	advcl	_	_
11	on	on	IN	IN	_	12	case	_	_
12	one	one	CD	CD	_	10	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	15	advmod	_	_
15	few	few	JJ	JJ	_	12	conj	_	_
16	immunodominant	immunodominant	JJ	JJ	_	17	amod	_	_
17	epitopes	epitope	NNS	NNS	_	12	dep	_	_
18	,	,	,	,	_	25	punct	_	_
19	one	one	CD	CD	_	20	nummod	_	_
20	approach	approach	NN	NN	_	25	nsubj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	circumvent	circumvent	VB	VB	_	20	acl	_	_
23	this	this	DT	DT	_	24	det	_	_
24	response	response	NN	NN	_	22	dobj	_	_
25	is	be	VBZ	VBZ	_	0	root	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	create	create	VB	VB	_	25	xcomp	_	_
28	vectors	vector	NNS	NNS	_	27	dobj	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	lack	lack	VBP	VBP	_	28	acl:relcl	_	_
31	these	these	DT	DT	_	33	det	_	_
32	immunodominant	immunodominant	JJ	JJ	_	33	amod	_	_
33	epitopes	epitope	NNS	NNS	_	30	dobj	_	_
34	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effectiveness	effectiveness	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	approach	approach	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	tested	test	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	immunizing	immunize	VBG	VBG	_	7	advcl	_	_
10	mice	mouse	NNS	NNS	_	9	dobj	_	_
11	with	with	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	group	group	NN	NN	_	15	compound	_	_
14	C	c	NN	NN	_	15	compound	_	_
15	adenoviruses	adenovirus	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	mouse	mouse	NN	NN	_	3	compound	_	_
3	strains	strain	NNS	NNS	_	22	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	C57BL/10SnJ	c57bl/10snj	NN	NN	_	3	dep	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	7	punct	_	_
7	H-2b	h-2b	NN	NN	_	5	appos	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	C3HeB/FeJ	c3heb/fej	NN	NN	_	5	conj	_	_
11	-LSB-	-lsb-	-LRB-	-LRB-	_	12	punct	_	_
12	H-2k	h-2k	NN	NN	_	10	appos	_	_
13	-RSB-	-rsb-	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	5	punct	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	BALB/cByJ	balb/cbyj	NN	NN	_	5	conj	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	H-2d	h-2d	NN	NN	_	16	appos	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
20	)	)	-RRB-	-RRB-	_	5	punct	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	immunized	immunize	VBN	VBN	_	0	root	_	_
23	with	with	IN	IN	_	25	case	_	_
24	wild-type	wild-type	JJ	JJ	_	25	amod	_	_
25	Ad	ad	NN	NN	_	22	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	Ad	ad	NN	NN	_	28	compound	_	_
28	vectors	vector	NNS	NNS	_	25	conj	_	_
29	lacking	lack	VBG	VBG	_	28	acl	_	_
30	the	the	DT	DT	_	34	det	_	_
31	immunodominant	immunodominant	JJ	JJ	_	32	amod	_	_
32	antigen	antigen	NN	NN	_	34	compound	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	s	s	NNS	NNS	_	29	dobj	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	22	punct	_	_
37	and	and	CC	CC	_	22	cc	_	_
38	the	the	DT	DT	_	40	det	_	_
39	CTL	ctl	NN	NN	_	40	compound	_	_
40	responses	response	NNS	NNS	_	42	nsubjpass	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	measured	measure	VBN	VBN	_	22	conj	_	_
43	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	C57BL/10	c57bl/10	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	B10	b10	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	mice	mouse	NNS	NNS	_	15	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	single	single	JJ	JJ	_	10	amod	_	_
10	inoculation	inoculation	NN	NN	_	15	nsubj	_	_
11	intraperitoneally	intraperitoneally	RB	RB	_	15	advmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	i.p.	i.p.	RB	RB	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	led	lead	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	recognition	recognition	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	immunodominant	immunodominant	JJ	JJ	_	22	amod	_	_
22	antigen	antigen	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	E1A	e1a	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	B10	b10	NN	NN	_	3	compound	_	_
3	mice	mouse	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	inoculated	inoculate	VBN	VBN	_	32	advcl	_	_
6	multiple	multiple	JJ	JJ	_	7	amod	_	_
7	times	time	NNS	NNS	_	5	dobj	_	_
8	either	either	CC	CC	_	10	cc:preconj	_	_
9	i.p.	i.p.	RB	RB	_	10	advmod	_	_
10	or	or	CC	CC	_	5	advmod	_	_
11	intranasally	intranasally	RB	RB	_	10	advmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	wild-type	wild-type	JJ	JJ	_	14	amod	_	_
14	Ad	ad	NN	NN	_	5	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	an	a	DT	DT	_	18	det	_	_
17	Ad	ad	NN	NN	_	18	compound	_	_
18	vector	vector	NN	NN	_	14	conj	_	_
19	lacking	lack	VBG	VBG	_	18	acl	_	_
20	most	most	JJS	JJS	_	19	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	E1	e1	NN	NN	_	24	compound	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	32	punct	_	_
26	subdominant	subdominant	JJ	JJ	_	27	amod	_	_
27	epitopes	epitope	NNS	NNS	_	32	nsubjpass	_	_
28	outside	outside	IN	IN	_	30	case	_	_
29	this	this	DT	DT	_	30	det	_	_
30	region	region	NN	NN	_	27	nmod	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	recognized	recognize	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	C3H	c3h	NN	NN	_	5	compound	_	_
5	mice	mouse	NNS	NNS	_	10	nsubj	_	_
6	inoculated	inoculate	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	9	case	_	_
8	wild-type	wild-type	JJ	JJ	_	9	amod	_	_
9	Ad	ad	NN	NN	_	6	nmod	_	_
10	recognized	recognize	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	12	det	_	_
12	epitope	epitope	NN	NN	_	10	dobj	_	_
13	mapping	map	VBG	VBG	_	12	acl	_	_
14	within	within	IN	IN	_	15	case	_	_
15	E1B	e1b	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	inoculated	inoculate	VBN	VBN	_	17	advcl	_	_
3	twice	twice	RB	RB	_	2	advmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	Ad	ad	NN	NN	_	6	compound	_	_
6	vectors	vector	NNS	NNS	_	2	nmod	_	_
7	lacking	lack	VBG	VBG	_	6	acl	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	E1A	e1a	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	E1B	e1b	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	17	punct	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	immunorecessive	immunorecessive	JJ	JJ	_	15	amod	_	_
15	epitopes	epitope	NNS	NNS	_	17	nsubjpass	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	recognized	recognize	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immune	immune	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	11	nsubj	_	_
4	to	to	TO	TO	_	5	case	_	_
5	Ad	ad	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	BALB/c	balb/c	NN	NN	_	8	compound	_	_
8	mice	mouse	NNS	NNS	_	3	nmod	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	complex	complex	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	CTLs	ctl	NNS	NNS	_	10	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	BALB/c	balb/c	NN	NN	_	4	compound	_	_
4	mice	mouse	NNS	NNS	_	1	nmod	_	_
5	inoculated	inoculate	VBN	VBN	_	4	acl	_	_
6	i.p.	i.p.	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	wild-type	wild-type	JJ	JJ	_	9	amod	_	_
9	Ad	ad	NN	NN	_	5	nmod	_	_
10	recognized	recognize	VBD	VBD	_	0	root	_	_
11	E1B	e1b	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	context	context	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	26	case	_	_
16	the	the	DT	DT	_	26	det	_	_
17	major	major	JJ	JJ	_	26	amod	_	_
18	histocompatibility	histocompatibility	NN	NN	_	26	compound	_	_
19	complex	complex	NN	NN	_	26	compound	_	_
20	(	(	-LRB-	-LRB-	_	26	punct	_	_
21	MHC	mhc	NN	NN	_	26	compound	_	_
22	)	)	-RRB-	-RRB-	_	26	punct	_	_
23	class	class	NN	NN	_	26	compound	_	_
24	I	i	CD	CD	_	26	nummod	_	_
25	Dd	dd	NN	NN	_	26	compound	_	_
26	allele	allele	NN	NN	_	14	nmod	_	_
27	and	and	CC	CC	_	11	cc	_	_
28	a	a	DT	DT	_	29	det	_	_
29	region	region	NN	NN	_	11	conj	_	_
30	outside	outside	IN	IN	_	31	case	_	_
31	E1	e1	NN	NN	_	29	nmod	_	_
32	associated	associate	VBD	VBD	_	29	acl	_	_
33	with	with	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	Kd	kd	NN	NN	_	36	compound	_	_
36	allele	allele	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	BALB/c	balb/c	NN	NN	_	3	compound	_	_
3	mice	mouse	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	inoculated	inoculate	VBN	VBN	_	17	advcl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	E1-deleted	e1-deleted	JJ	JJ	_	9	amod	_	_
8	Ad	ad	NN	NN	_	9	compound	_	_
9	vectors	vector	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	17	punct	_	_
11	only	only	RB	RB	_	15	advmod	_	_
12	the	the	DT	DT	_	15	det	_	_
13	immunodominant	immunodominant	JJ	JJ	_	15	amod	_	_
14	Kd-restricted	kd-restricted	JJ	JJ	_	15	amod	_	_
15	epitope	epitope	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	recognized	recognize	VBN	VBN	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	Dd-restricted	dd-restricted	JJ	JJ	_	21	amod	_	_
21	CTLs	ctl	NNS	NNS	_	24	nsubj	_	_
22	did	do	VBD	VBD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	develop	develop	VB	VB	_	17	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	report	report	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	emergence	emergence	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CTLs	ctl	NNS	NNS	_	6	nmod	_	_
9	against	against	IN	IN	_	11	case	_	_
10	immunorecessive	immunorecessive	JJ	JJ	_	11	amod	_	_
11	epitopes	epitope	NNS	NNS	_	6	nmod	_	_
12	following	follow	VBG	VBG	_	14	case	_	_
13	multiple	multiple	JJ	JJ	_	14	amod	_	_
14	administrations	administration	NNS	NNS	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Ad	ad	NN	NN	_	17	compound	_	_
17	vectors	vector	NNS	NNS	_	14	nmod	_	_
18	lacking	lack	VBG	VBG	_	17	acl	_	_
19	immunodominant	immunodominant	JJ	JJ	_	20	amod	_	_
20	antigens	antigen	NNS	NNS	_	18	dobj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	dependent	dependent	JJ	JJ	_	3	ccomp	_	_
23	on	on	IN	IN	_	24	case	_	_
24	haplotype	haplotype	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	could	could	MD	MD	_	27	aux	_	_
27	present	present	VB	VB	_	22	conj	_	_
28	an	a	DT	DT	_	29	det	_	_
29	obstacle	obstacle	NN	NN	_	27	dobj	_	_
30	to	to	TO	TO	_	32	case	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	therapy	therapy	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	37	case	_	_
34	an	a	DT	DT	_	37	det	_	_
35	MHC-diverse	mhc-diverse	JJ	JJ	_	37	amod	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	population	population	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	negative	negative	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	0	root	_	_
5	containing	contain	VBG	VBG	_	4	acl	_	_
6	a	a	DT	DT	_	9	det	_	_
7	glucocorticosteroid	glucocorticosteroid	NN	NN	_	9	compound	_	_
8	response	response	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	5	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	nGRE	ngre	NN	NN	_	4	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	interleukin-1beta	interleukin-1beta	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	4	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Interleukin-1	interleukin-1	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-1beta	il-1beta	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	one	one	CD	CD	_	0	root	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	most	most	RBS	RBS	_	11	advmod	_	_
11	important	important	JJ	JJ	_	13	amod	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	mediators	mediator	NNS	NNS	_	7	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	inflammatory	inflammatory	JJ	JJ	_	7	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	immunological	immunological	JJ	JJ	_	16	conj	_	_
19	diseases	disease	NNS	NNS	_	16	dep	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	IL-1beta	il-1beta	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	studied	study	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	13	case	_	_
12	several	several	JJ	JJ	_	13	amod	_	_
13	years	year	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	a	a	DT	DT	_	19	det	_	_
17	few	few	JJ	JJ	_	19	amod	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	elements	element	NNS	NNS	_	22	nsubjpass	_	_
20	have	have	VBP	VBP	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	discovered	discover	VBN	VBN	_	10	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	region	region	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	about	about	IN	IN	_	8	case	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IL-1beta	il-1beta	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	8	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	play	play	VB	VB	_	8	acl:relcl	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	anti-inflammatory	anti-inflammatory	JJ	JJ	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	immunosuppressive	immunosuppressive	JJ	JJ	_	24	conj	_	_
27	effects	effect	NNS	NNS	_	24	dep	_	_
28	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	negative	negative	JJ	JJ	_	7	amod	_	_
6	regulatory	regulatory	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	3	dobj	_	_
8	located	located	JJ	JJ	_	7	amod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	region	region	NN	NN	_	8	nmod	_	_
12	between	between	IN	IN	_	13	case	_	_
13	-685	-685	CD	CD	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-395	-395	CD	CD	_	13	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Within	within	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	a	a	DT	DT	_	10	det	_	_
6	19-bp	19-bp	JJ	JJ	_	10	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	17	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	-570	-570	CD	CD	_	14	nummod	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	-552	-552	CD	CD	_	10	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	characterized	characterize	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	21	case	_	_
19	DNase	dnase	NN	NN	_	20	compound	_	_
20	I	i	NN	NN	_	21	compound	_	_
21	footprinting	footprinting	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	electromobility	electromobility	NN	NN	_	24	compound	_	_
24	shift	shift	NN	NN	_	21	conj	_	_
25	assay	assay	NN	NN	_	21	dep	_	_
26	.	.	.	.	_	17	punct	_	_

1	A	a	NN	NN	_	21	nsubjpass	_	_
2	consensus	consensus	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	1	dep	_	_
4	for	for	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	negative	negative	JJ	JJ	_	9	amod	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
8	response	response	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	1	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	nGRE	ngre	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	1	cc	_	_
14	a	a	DT	DT	_	19	det	_	_
15	transcription	transcription	NN	NN	_	19	compound	_	_
16	activator	activator	NN	NN	_	19	compound	_	_
17	protein-2	protein-2	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	1	conj	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	noted	note	VBN	VBN	_	0	root	_	_
22	within	within	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	footprint	footprint	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	21	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	2.5-fold	2.5-fold	JJ	JJ	_	6	amod	_	_
6	increase	increase	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	when	when	WRB	WRB	_	16	advmod	_	_
11	this	this	DT	DT	_	14	det	_	_
12	19-bp	19-bp	JJ	JJ	_	14	amod	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	site	site	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	deleted	delete	VBN	VBN	_	3	advcl	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	constructs	construct	NNS	NNS	_	16	nmod	_	_
21	IL-1beta/CAT	il-1beta/cat	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-1beta/SV40	il-1beta/sv40	NN	NN	_	24	compound	_	_
24	promoter/CAT	promoter/cat	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	10(-8)	10(-8)	CD	CD	_	4	nummod	_	_
4	M	m	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	repressed	repress	VBD	VBD	_	0	root	_	_
7	chloramphenicol	chloramphenicol	NN	NN	_	8	compound	_	_
8	acetyltransferase	acetyltransferase	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CAT	cat	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	production	production	NN	NN	_	6	dobj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	75	75	CD	CD	_	15	nummod	_	_
15	%	%	NN	NN	_	6	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	wild-type	wild-type	JJ	JJ	_	19	amod	_	_
19	fragment	fragment	NN	NN	_	6	nmod	_	_
20	but	but	CC	CC	_	19	cc	_	_
21	not	not	RB	RB	_	25	neg	_	_
22	in	in	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	deletion	deletion	NN	NN	_	25	compound	_	_
25	mutant	mutant	NN	NN	_	19	conj	_	_
26	lacking	lack	VBG	VBG	_	25	acl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	19-bp	19-bp	JJ	JJ	_	29	amod	_	_
29	site	site	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	about	about	RB	RB	_	6	advmod	_	_
5	150	150	CD	CD	_	6	nummod	_	_
6	kD	kd	NN	NN	_	2	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	bound	bind	VBD	VBD	_	2	acl:relcl	_	_
9	to	to	TO	TO	_	13	case	_	_
10	this	this	DT	DT	_	13	det	_	_
11	negative	negative	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	sequence	sequence	NN	NN	_	8	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	identified	identify	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	UV	uv	NN	NN	_	18	compound	_	_
18	cross-linking	cross-linking	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	description	description	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	negative	negative	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	5	nmod	_	_
11	responsive	responsive	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	11	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	12	case	_	_
9	X-linked	x-linked	JJ	JJ	_	12	amod	_	_
10	severe	severe	JJ	JJ	_	12	amod	_	_
11	combined	combined	JJ	JJ	_	12	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-4	il-4	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	B	b	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	10	conj	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	10	dep	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	mediates	mediate	VBZ	VBZ	_	8	conj	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	effects	effect	NNS	NNS	_	16	dobj	_	_
19	via	via	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	contains	contain	VBZ	VBZ	_	21	acl:relcl	_	_
24	gammac	gammac	NN	NN	_	23	dobj	_	_
25	.	.	.	.	_	8	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	15	nsubj	_	_
3	derived	derive	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	X-linked	x-linked	JJ	JJ	_	10	amod	_	_
8	severe	severe	JJ	JJ	_	10	amod	_	_
9	combined	combined	JJ	JJ	_	10	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	X-SCID	x-scid	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	deficient	deficient	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	gammac	gammac	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	provide	provide	VBP	VBP	_	15	conj	_	_
20	a	a	DT	DT	_	22	det	_	_
21	useful	useful	JJ	JJ	_	22	amod	_	_
22	model	model	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	26	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	dissect	dissect	VB	VB	_	22	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	role	role	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	subunit	subunit	NN	NN	_	28	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	IL-4-mediated	il-4-mediated	JJ	JJ	_	34	amod	_	_
34	signaling	signaling	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	31	mark	_	_
4	although	although	IN	IN	_	13	mark	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	X-SCID	x-scid	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	result	result	VB	VB	_	31	advcl	_	_
14	in	in	IN	IN	_	21	case	_	_
15	Janus	janus	NN	NN	_	17	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	kinase-3	kinase-3	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	JAK3	jak3	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
22	,	,	,	,	_	31	punct	_	_
23	other	other	JJ	JJ	_	25	amod	_	_
24	IL-4	il-4	NN	NN	_	25	compound	_	_
25	substrates	substrate	NNS	NNS	_	31	nsubjpass	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	JAK1	jak1	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	IRS-1	irs-1	NN	NN	_	27	conj	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	phosphorylated	phosphorylate	VBN	VBN	_	2	ccomp	_	_
32	.	.	.	.	_	2	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	detected	detect	VBD	VBD	_	0	root	_	_
5	signal	signal	NN	NN	_	6	compound	_	_
6	transducers	transducer	NNS	NNS	_	16	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	activators	activator	NNS	NNS	_	10	compound	_	_
9	of	of	IN	IN	_	10	amod	_	_
10	transcription	transcription	NN	NN	_	6	conj	_	_
11	6	6	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	STAT6	stat6	NN	NN	_	6	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	X-SCID	x-scid	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	4	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	wide	wide	JJ	JJ	_	28	amod	_	_
28	range	range	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	gammac	gammac	NN	NN	_	31	compound	_	_
31	mutations	mutation	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	reconstitution	reconstitution	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	these	these	DT	DT	_	8	det	_	_
6	X-SCID	x-scid	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	gammac	gammac	NN	NN	_	8	nmod	_	_
11	enhanced	enhance	VBD	VBD	_	0	root	_	_
12	IL-4-mediated	il-4-mediated	JJ	JJ	_	13	amod	_	_
13	responses	response	NNS	NNS	_	11	dobj	_	_
14	including	include	VBG	VBG	_	16	case	_	_
15	STAT6	stat6	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	conj	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	resulted	result	VBD	VBD	_	11	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	increased	increase	VBN	VBN	_	26	amod	_	_
25	CD23	cd23	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	gammac	gammac	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	necessary	necessary	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	trigger	trigger	VB	VB	_	6	xcomp	_	_
9	IL-4-mediated	il-4-mediated	JJ	JJ	_	10	amod	_	_
10	responses	response	NNS	NNS	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	but	but	CC	CC	_	6	cc	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	presence	presence	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	important	important	JJ	JJ	_	6	conj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	optimal	optimal	JJ	JJ	_	22	amod	_	_
22	IL-4-signaling	il-4-signaling	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	two	two	CD	CD	_	9	nummod	_	_
6	distinct	distinct	JJ	JJ	_	9	amod	_	_
7	IL-4	il-4	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	10	nsubj	_	_
10	exist	exist	VBP	VBP	_	3	ccomp	_	_
11	.	.	.	.	_	3	punct	_	_

1	Upregulation	upregulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-Fos	c-fos	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	T	t	NN	NN	_	1	nmod	_	_
7	lymphoid	lymphoid	JJ	JJ	_	6	amod	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	monocytic	monocytic	JJ	JJ	_	6	conj	_	_
10	cells	cell	NNS	NNS	_	6	dep	_	_
11	by	by	IN	IN	_	16	case	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	16	compound	_	_
14	virus-1	virus-1	NN	NN	_	16	compound	_	_
15	Tat	tat	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	1	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
3	Tat	tat	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	immunodeficiency	immunodeficiency	NN	NN	_	10	compound	_	_
9	virus	virus	NN	NN	_	10	compound	_	_
10	type-1	type-1	NN	NN	_	4	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HIV-1	hiv-1	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	essential	essential	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	viral	viral	JJ	JJ	_	18	amod	_	_
18	replication	replication	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	shows	show	VBZ	VBZ	_	15	conj	_	_
22	pleiotropic	pleiotropic	JJ	JJ	_	23	amod	_	_
23	activities	activity	NNS	NNS	_	21	dobj	_	_
24	on	on	IN	IN	_	27	case	_	_
25	various	various	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	functions	function	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	get	get	VB	VB	_	0	root	_	_
3	further	further	JJ	JJ	_	4	amod	_	_
4	insights	insight	NNS	NNS	_	2	dobj	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	molecular	molecular	JJ	JJ	_	8	amod	_	_
8	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
9	underlying	underlie	VBG	VBG	_	8	acl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	biological	biological	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Tat	tat	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	investigated	investigate	VBD	VBD	_	2	parataxis	_	_
18	the	the	DT	DT	_	19	det	_	_
19	effect	effect	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	endogenous	endogenous	JJ	JJ	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	exogenous	exogenous	JJ	JJ	_	21	conj	_	_
24	Tat	tat	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	dep	_	_
26	on	on	IN	IN	_	29	case	_	_
27	c-fos	c-fos	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	19	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	lymphoblastoid	lymphoblastoid	NN	NN	_	29	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	Jurkat	jurkat	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	monocytic	monocytic	JJ	JJ	_	32	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	U937	u937	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	lines	line	NNS	NNS	_	32	dep	_	_
43	,	,	,	,	_	32	punct	_	_
44	as	as	RB	RB	_	32	cc	_	_
45	well	well	RB	RB	_	44	mwe	_	_
46	as	as	IN	IN	_	44	mwe	_	_
47	in	in	IN	IN	_	52	case	_	_
48	primary	primary	JJ	JJ	_	52	amod	_	_
49	peripheral	peripheral	JJ	JJ	_	52	amod	_	_
50	blood	blood	NN	NN	_	52	compound	_	_
51	mononuclear	mononuclear	JJ	JJ	_	52	amod	_	_
52	cells	cell	NNS	NNS	_	32	conj	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	PBMC	pbmc	NNS	NNS	_	52	appos	_	_
55	)	)	-RRB-	-RRB-	_	54	punct	_	_
56	.	.	.	.	_	2	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	cotransfection	cotransfection	NN	NN	_	41	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	tat	tat	NN	NN	_	5	compound	_	_
5	cDNA	cdna	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	sense	sense	JJ	JJ	_	8	amod	_	_
8	orientation	orientation	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	tat/S	tat/s	NN	NN	_	5	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	2	punct	_	_
13	together	together	RB	RB	_	16	advmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	plasmid	plasmid	NN	NN	_	2	nmod	_	_
17	containing	contain	VBG	VBG	_	16	acl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	c-fos	c-fos	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	17	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	FC3	fc3	NN	NN	_	20	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	from	from	IN	IN	_	25	case	_	_
25	-711	-711	CD	CD	_	22	acl	_	_
26	to	to	TO	TO	_	27	case	_	_
27	+42	+42	CD	CD	_	22	acl	_	_
28	)	)	-RRB-	-RRB-	_	22	punct	_	_
29	in	in	IN	IN	_	30	case	_	_
30	front	front	NN	NN	_	2	nmod	_	_
31	of	of	IN	IN	_	39	case	_	_
32	the	the	DT	DT	_	39	det	_	_
33	bacterial	bacterial	JJ	JJ	_	39	amod	_	_
34	chloramphenicol	chloramphenicol	NN	NN	_	39	compound	_	_
35	acetyltransferase	acetyltransferase	NN	NN	_	39	compound	_	_
36	(	(	-LRB-	-LRB-	_	39	punct	_	_
37	CAT	cat	NN	NN	_	39	compound	_	_
38	)	)	-RRB-	-RRB-	_	39	punct	_	_
39	gene	gene	NN	NN	_	30	nmod	_	_
40	significantly	significantly	RB	RB	_	41	advmod	_	_
41	enhanced	enhance	VBD	VBD	_	0	root	_	_
42	CAT	cat	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	41	dobj	_	_
44	in	in	IN	IN	_	46	case	_	_
45	Jurkat	jurkat	NN	NN	_	46	compound	_	_
46	cells	cell	NNS	NNS	_	43	nmod	_	_
47	activated	activate	VBN	VBN	_	46	acl	_	_
48	by	by	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	addition	addition	NN	NN	_	47	nmod	_	_
51	of	of	IN	IN	_	56	case	_	_
52	15	15	CD	CD	_	53	compound	_	_
53	%	%	NN	NN	_	56	amod	_	_
54	fetal	fetal	JJ	JJ	_	56	amod	_	_
55	calf	calf	NN	NN	_	56	compound	_	_
56	serum	serum	NN	NN	_	50	nmod	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	FCS	fcs	NN	NN	_	56	appos	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	or	or	CC	CC	_	56	cc	_	_
61	5	5	CD	CD	_	62	compound	_	_
62	micrograms/mL	micrograms/ml	NNS	NNS	_	63	amod	_	_
63	phytohemagglutinin	phytohemagglutinin	NN	NN	_	56	conj	_	_
64	plus	plus	CC	CC	_	63	cc	_	_
65	10(-7)	10(-7)	CD	CD	_	66	compound	_	_
66	mol/L	mol/l	NN	NN	_	69	amod	_	_
67	phorbol	phorbol	NN	NN	_	69	compound	_	_
68	myristate	myristate	NN	NN	_	69	compound	_	_
69	acetate	acetate	NN	NN	_	63	conj	_	_
70	(	(	-LRB-	-LRB-	_	71	punct	_	_
71	PMA	pma	NN	NN	_	69	appos	_	_
72	)	)	-RRB-	-RRB-	_	71	punct	_	_
73	and	and	CC	CC	_	46	cc	_	_
74	U937	u937	NN	NN	_	75	compound	_	_
75	cells	cell	NNS	NNS	_	46	conj	_	_
76	activated	activate	VBN	VBN	_	75	acl	_	_
77	by	by	IN	IN	_	80	case	_	_
78	15	15	CD	CD	_	79	compound	_	_
79	%	%	NN	NN	_	80	amod	_	_
80	FCS	fcs	NN	NN	_	76	nmod	_	_
81	or	or	CC	CC	_	80	cc	_	_
82	10(-7)	10(-7)	CD	CD	_	83	compound	_	_
83	mol/L	mol/l	NN	NN	_	84	amod	_	_
84	PMA	pma	NN	NN	_	80	conj	_	_
85	.	.	.	.	_	41	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	specifically	specifically	RB	RB	_	5	advmod	_	_
5	due	due	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	Tat	tat	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	since	since	IN	IN	_	49	mark	_	_
10	Jurkat	jurkat	NN	NN	_	49	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	U937	u937	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	cotransfected	cotransfect	VBN	VBN	_	10	acl	_	_
15	either	either	CC	CC	_	18	cc:preconj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	tat	tat	NN	NN	_	18	compound	_	_
18	cDNA	cdna	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	antisense	antisense	JJ	JJ	_	21	amod	_	_
21	orientation	orientation	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	tat/AS	tat/as	NN	NN	_	18	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	18	punct	_	_
26	tat	tat	NN	NN	_	18	appos	_	_
27	carrying	carry	VBG	VBG	_	26	acl	_	_
28	a	a	DT	DT	_	29	det	_	_
29	mutation	mutation	NN	NN	_	27	dobj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	aminoacid	aminoacid	JJ	JJ	_	33	amod	_	_
33	cys22-gly22	cys22-gly22	NN	NN	_	27	nmod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	tat	tat	NN	NN	_	36	compound	_	_
36	22/S	22/s	NN	NN	_	26	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	or	or	CC	CC	_	18	cc	_	_
39	with	with	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	backbone	backbone	NN	NN	_	42	compound	_	_
42	vector	vector	NN	NN	_	18	conj	_	_
43	alone	alone	RB	RB	_	42	advmod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	pRPneo-SL3	prpneo-sl3	NN	NN	_	42	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	did	do	VBD	VBD	_	49	aux	_	_
48	not	not	RB	RB	_	49	neg	_	_
49	show	show	VB	VB	_	5	advcl	_	_
50	any	any	DT	DT	_	52	det	_	_
51	significant	significant	JJ	JJ	_	52	amod	_	_
52	difference	difference	NN	NN	_	49	dobj	_	_
53	in	in	IN	IN	_	56	case	_	_
54	c-fos	c-fos	NN	NN	_	55	compound	_	_
55	promoter	promoter	NN	NN	_	56	compound	_	_
56	activity	activity	NN	NN	_	49	nmod	_	_
57	as	as	IN	IN	_	58	mark	_	_
58	compared	compare	VBN	VBN	_	49	advcl	_	_
59	to	to	TO	TO	_	60	case	_	_
60	cells	cell	NNS	NNS	_	58	nmod	_	_
61	transfected	transfect	VBN	VBN	_	60	acl	_	_
62	with	with	IN	IN	_	64	case	_	_
63	FC3	fc3	NN	NN	_	64	compound	_	_
64	plasmid	plasmid	NN	NN	_	61	nmod	_	_
65	alone	alone	RB	RB	_	64	advmod	_	_
66	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	11	advcl	_	_
3	deletion	deletion	NN	NN	_	4	compound	_	_
4	mutants	mutant	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	c-fos	c-fos	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	found	find	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	22	mark	_	_
13	the	the	DT	DT	_	16	det	_	_
14	minimal	minimal	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	22	nsubj	_	_
17	required	require	VBN	VBN	_	16	acl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	Tat	tat	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	was	be	VBD	VBD	_	22	cop	_	_
22	located	located	JJ	JJ	_	11	ccomp	_	_
23	between	between	IN	IN	_	24	case	_	_
24	nucleotides	nucleotide	NNS	NNS	_	22	nmod	_	_
25	-404/-220	-404/-220	CD	CD	_	24	nummod	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	that	that	IN	IN	_	45	mark	_	_
28	the	the	DT	DT	_	31	det	_	_
29	serum	serum	NN	NN	_	31	compound	_	_
30	responsive	responsive	JJ	JJ	_	31	amod	_	_
31	element	element	NN	NN	_	45	nsubj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	SRE	sre	NN	NN	_	31	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	-317/-288	-317/-288	CD	CD	_	33	amod	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	,	,	,	,	_	31	punct	_	_
38	present	present	JJ	JJ	_	31	amod	_	_
39	within	within	IN	IN	_	41	case	_	_
40	this	this	DT	DT	_	41	det	_	_
41	region	region	NN	NN	_	38	nmod	_	_
42	,	,	,	,	_	31	punct	_	_
43	was	be	VBD	VBD	_	45	cop	_	_
44	still	still	RB	RB	_	45	advmod	_	_
45	responsive	responsive	JJ	JJ	_	22	conj	_	_
46	to	to	TO	TO	_	47	case	_	_
47	Tat	tat	NN	NN	_	45	nmod	_	_
48	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	single	single	JJ	JJ	_	4	amod	_	_
3	point	point	NN	NN	_	4	compound	_	_
4	mutation	mutation	NN	NN	_	9	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	SRE	sre	NN	NN	_	4	nmod	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	abrogated	abrogate	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	responsiveness	responsiveness	NN	NN	_	9	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	tat/S	tat/s	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	4	amod	_	_
2	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
3	Tat	tat	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	7	nsubj	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	upregulate	upregulate	VB	VB	_	7	xcomp	_	_
10	c-fos	c-fos	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	serum-activated	serum-activated	JJ	JJ	_	15	amod	_	_
15	Jurkat	jurkat	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	U937	u937	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	as	as	RB	RB	_	12	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	endogenous	endogenous	JJ	JJ	_	26	amod	_	_
24	c-fos	c-fos	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	12	conj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	c-Fos	c-fos	NN	NN	_	30	compound	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	synthesis	synthesis	NN	NN	_	26	conj	_	_
31	in	in	IN	IN	_	35	case	_	_
32	both	both	CC	CC	_	35	cc:preconj	_	_
33	serum-activated	serum-activated	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	26	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	primary	primary	JJ	JJ	_	38	amod	_	_
38	PBMC	pbmc	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	7	punct	_	_

1	c-Fos	c-fos	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	essential	essential	JJ	JJ	_	4	xcomp	_	_
6	for	for	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	optimal	optimal	JJ	JJ	_	9	amod	_	_
9	transactivation	transactivation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	HIV-1	hiv-1	NN	NN	_	9	nmod	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	repeat	repeat	NN	NN	_	12	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LTR	ltr	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	by	by	IN	IN	_	20	case	_	_
20	Tat	tat	NN	NN	_	9	nmod	_	_
21	:	:	:	:	_	4	punct	_	_
22	incubation	incubation	NN	NN	_	36	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Jurkat	jurkat	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	antisense	antisense	JJ	JJ	_	22	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	but	but	CC	CC	_	30	cc	_	_
30	not	not	RB	RB	_	27	cc	_	_
31	sense	sense	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	c-fos	c-fos	NN	NN	_	34	compound	_	_
34	oligonucleotides	oligonucleotide	NNS	NNS	_	27	conj	_	_
35	significantly	significantly	RB	RB	_	36	advmod	_	_
36	reduced	reduce	VBD	VBD	_	4	parataxis	_	_
37	either	either	CC	CC	_	40	cc:preconj	_	_
38	the	the	DT	DT	_	40	det	_	_
39	Tat-enhanced	tat-enhanced	JJ	JJ	_	40	amod	_	_
40	expression	expression	NN	NN	_	36	dobj	_	_
41	of	of	IN	IN	_	45	case	_	_
42	an	a	DT	DT	_	45	det	_	_
43	LTR-CAT	ltr-cat	NN	NN	_	45	compound	_	_
44	reporter	reporter	NN	NN	_	45	compound	_	_
45	construct	construct	NN	NN	_	40	nmod	_	_
46	or	or	CC	CC	_	40	cc	_	_
47	the	the	DT	DT	_	48	det	_	_
48	levels	level	NNS	NNS	_	40	conj	_	_
49	of	of	IN	IN	_	51	case	_	_
50	gag	gag	NN	NN	_	51	compound	_	_
51	p24	p24	NN	NN	_	48	nmod	_	_
52	in	in	IN	IN	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	culture	culture	NN	NN	_	55	compound	_	_
55	supernatants	supernatant	NNS	NNS	_	48	nmod	_	_
56	of	of	IN	IN	_	58	case	_	_
57	Jurkat	jurkat	NN	NN	_	58	compound	_	_
58	cells	cell	NNS	NNS	_	55	nmod	_	_
59	and	and	CC	CC	_	58	cc	_	_
60	PBMC	pbmc	NN	NN	_	58	conj	_	_
61	acutely	acutely	RB	RB	_	62	advmod	_	_
62	infected	infect	VBN	VBN	_	58	acl	_	_
63	with	with	IN	IN	_	64	case	_	_
64	HIV-1	hiv-1	NN	NN	_	62	nmod	_	_
65	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	c-fos	c-fos	NN	NN	_	7	compound	_	_
7	upregulation	upregulation	NN	NN	_	12	nsubj	_	_
8	mediated	mediate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	Tat	tat	NN	NN	_	8	nmod	_	_
11	might	might	MD	MD	_	12	aux	_	_
12	play	play	VB	VB	_	3	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	control	control	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	viral	viral	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transactivation	transactivation	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	alterations	alteration	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	upstream	upstream	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	estrogen	estrogen	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	21	case	_	_
16	an	a	DT	DT	_	21	det	_	_
17	ER-negative	er-negative	JJ	JJ	_	21	amod	_	_
18	breast	breast	NN	NN	_	21	compound	_	_
19	cancer	cancer	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	line	line	NN	NN	_	4	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	Given	given	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	important	important	JJ	JJ	_	4	amod	_	_
4	role	role	NN	NN	_	23	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	estrogen	estrogen	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ER	er	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	development	development	NN	NN	_	4	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	physiology	physiology	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	breast	breast	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	essential	essential	JJ	JJ	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	delineate	delineate	VB	VB	_	23	xcomp	_	_
26	the	the	DT	DT	_	27	det	_	_
27	mechanisms	mechanism	NNS	NNS	_	25	dobj	_	_
28	responsible	responsible	JJ	JJ	_	27	amod	_	_
29	for	for	IN	IN	_	32	case	_	_
30	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
31	failed	failed	JJ	JJ	_	32	amod	_	_
32	expression	expression	NN	NN	_	28	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	some	some	DT	DT	_	36	det	_	_
35	breast	breast	NN	NN	_	36	compound	_	_
36	tumors	tumor	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	sequenced	sequence	VBN	VBN	_	3	conj	_	_
6	a	a	DT	DT	_	7	det	_	_
7	portion	portion	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	ER	er	NN	NN	_	7	nmod	_	_
11	upstream	upstream	JJ	JJ	_	13	amod	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	10	dep	_	_
14	from	from	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	ER-positive	er-positive	JJ	JJ	_	17	amod	_	_
17	MCF-7	mcf-7	NN	NN	_	3	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	25	det	_	_
20	ER-negative	er-negative	JJ	JJ	_	25	amod	_	_
21	MDA-MB-231	mda-mb-231	NN	NN	_	25	compound	_	_
22	breast	breast	NN	NN	_	25	compound	_	_
23	cancer	cancer	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	17	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	determine	determine	VB	VB	_	3	xcomp	_	_
28	if	if	IN	IN	_	34	mark	_	_
29	sequence	sequence	NN	NN	_	30	compound	_	_
30	alterations	alteration	NNS	NNS	_	34	nsubj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	region	region	NN	NN	_	30	nmod	_	_
34	account	account	VBP	VBP	_	27	advcl	_	_
35	for	for	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	ER-negative	er-negative	JJ	JJ	_	38	amod	_	_
38	phenotype	phenotype	NN	NN	_	34	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	some	some	DT	DT	_	41	det	_	_
41	tumors	tumor	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	From	from	IN	IN	_	2	case	_	_
2	this	this	DT	DT	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	number	number	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	variations	variation	NNS	NNS	_	7	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	sequences	sequence	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	two	two	CD	CD	_	18	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	14	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	determined	determine	VBN	VBN	_	7	acl:relcl	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	associated	associate	VBN	VBN	_	18	xcomp	_	_
22	with	with	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	50	50	CD	CD	_	25	compound	_	_
25	%	%	NN	NN	_	26	amod	_	_
26	decrease	decrease	NN	NN	_	21	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	CAT	cat	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	1	nmod	_	_
6	MEF2C	mef2c	NN	NN	_	5	dep	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	MAP	map	NN	NN	_	11	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	p38	p38	NN	NN	_	1	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	inflammation	inflammation	NN	NN	_	1	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	For	for	IN	IN	_	9	mark	_	_
2	cells	cell	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	innate	innate	JJ	JJ	_	7	amod	_	_
6	immune	immune	JJ	JJ	_	7	amod	_	_
7	system	system	NN	NN	_	2	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	mount	mount	VB	VB	_	19	advcl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	host	host	NN	NN	_	13	compound	_	_
12	defence	defence	NN	NN	_	13	compound	_	_
13	response	response	NN	NN	_	9	dobj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	infection	infection	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	they	they	PRP	PRP	_	19	nsubj	_	_
18	must	must	MD	MD	_	19	aux	_	_
19	recognize	recognize	VB	VB	_	0	root	_	_
20	products	product	NNS	NNS	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	microbial	microbial	JJ	JJ	_	23	amod	_	_
23	pathogens	pathogen	NNS	NNS	_	20	nmod	_	_
24	such	such	JJ	JJ	_	26	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	lipopolysaccharide	lipopolysaccharide	NN	NN	_	20	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	LPS	lps	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	,	,	,	,	_	26	punct	_	_
31	the	the	DT	DT	_	32	det	_	_
32	endotoxin	endotoxin	NN	NN	_	26	appos	_	_
33	secreted	secrete	VBN	VBN	_	32	acl	_	_
34	by	by	IN	IN	_	36	case	_	_
35	Gram-negative	gram-negative	JJ	JJ	_	36	amod	_	_
36	bacteria	bacterium	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	cellular	cellular	JJ	JJ	_	3	amod	_	_
3	responses	response	NNS	NNS	_	4	nsubj	_	_
4	require	require	VBP	VBP	_	0	root	_	_
5	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
6	signalling	signalling	NN	NN	_	7	compound	_	_
7	pathways	pathway	NNS	NNS	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	such	such	JJ	JJ	_	18	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	the	the	DT	DT	_	18	det	_	_
12	four	four	CD	CD	_	18	nummod	_	_
13	MAP	map	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	MAPK	mapk	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	pathways	pathway	NNS	NNS	_	7	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	mammalian	mammalian	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	8	nmod	_	_
4	the	the	DT	DT	_	6	det	_	_
5	MAPK	mapk	NN	NN	_	6	compound	_	_
6	p38	p38	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	thought	think	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	regulation	regulation	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	responses	response	NNS	NNS	_	16	nmod	_	_
20	during	during	IN	IN	_	21	case	_	_
21	infection	infection	NN	NN	_	16	nmod	_	_
22	through	through	IN	IN	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	effects	effect	NNS	NNS	_	10	nmod	_	_
25	on	on	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	proinflammatory	proinflammatory	JJ	JJ	_	30	amod	_	_
30	molecules	molecule	NNS	NNS	_	24	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	means	means	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	mark	_	_
4	understanding	understand	VBG	VBG	_	2	acl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p38	p38	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	responses	response	NNS	NNS	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	identify	identify	VB	VB	_	12	xcomp	_	_
15	proteins	protein	NNS	NNS	_	14	dobj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	functions	function	NNS	NNS	_	15	nmod	_	_
18	regulated	regulate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	p38-catalysed	p38-catalysed	JJ	JJ	_	21	amod	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	link	link	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	p38	p38	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	member	member	NN	NN	_	9	conj	_	_
13	of	of	IN	IN	_	21	case	_	_
14	the	the	DT	DT	_	21	det	_	_
15	myocyte-enhancer	myocyte-enhancer	NN	NN	_	21	compound	_	_
16	factor	factor	NN	NN	_	21	compound	_	_
17	2	2	CD	CD	_	21	nummod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	MEF2	mef2	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	group	group	NN	NN	_	12	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	9	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	LPS	lps	NN	NN	_	9	nsubj	_	_
9	increases	increase	VBZ	VBZ	_	2	ccomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transactivation	transactivation	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	MEF2C	mef2c	NN	NN	_	12	nmod	_	_
15	through	through	IN	IN	_	17	case	_	_
16	p38-catalysed	p38-catalysed	JJ	JJ	_	17	amod	_	_
17	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	consequence	consequence	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	MEF2C	mef2c	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	increased	increase	VBN	VBN	_	10	amod	_	_
8	c-jun	c-jun	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	p38	p38	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	influence	influence	VB	VB	_	3	ccomp	_	_
8	host	host	NN	NN	_	7	dobj	_	_
9	defence	defence	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	inflammation	inflammation	NN	NN	_	8	conj	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	maintaining	maintain	VBG	VBG	_	7	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	balance	balance	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	c-Jun	c-jun	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	15	nmod	_	_
19	consumed	consume	VBN	VBN	_	18	acl	_	_
20	during	during	IN	IN	_	21	case	_	_
21	infection	infection	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Possible	possible	JJ	JJ	_	2	amod	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	germline	germline	NN	NN	_	12	compound	_	_
10	C	c	NN	NN	_	12	compound	_	_
11	epsilon	epsilon	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	2	nmod	_	_
13	in	in	IN	IN	_	20	case	_	_
14	a	a	DT	DT	_	20	det	_	_
15	human	human	JJ	JJ	_	20	amod	_	_
16	Burkitt	burkitt	NN	NN	_	20	compound	_	_
17	lymphoma	lymphoma	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	8	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	plays	play	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	broad	broad	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	but	but	CC	CC	_	8	cc	_	_
17	it	it	PRP	PRP	_	20	nsubj	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	evident	evident	JJ	JJ	_	8	conj	_	_
21	whether	whether	IN	IN	_	24	mark	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	24	nsubj	_	_
24	acts	act	VBZ	VBZ	_	20	ccomp	_	_
25	as	as	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	messenger	messenger	NN	NN	_	28	compound	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	for	for	IN	IN	_	33	case	_	_
30	germline	germline	NN	NN	_	33	compound	_	_
31	C	c	NN	NN	_	33	compound	_	_
32	epsilon	epsilon	NN	NN	_	33	compound	_	_
33	transcription	transcription	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	cascade	cascade	NN	NN	_	21	nsubj	_	_
8	triggered	trigger	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	interleukin-4	interleukin-4	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-4	il-4	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	or	or	CC	CC	_	10	cc	_	_
15	anti-CD40	anti-cd40	JJ	JJ	_	17	amod	_	_
16	monoclonal	monoclonal	JJ	JJ	_	17	amod	_	_
17	antibody	antibody	NN	NN	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	mAb	mab	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	participates	participate	VBZ	VBZ	_	2	ccomp	_	_
22	in	in	IN	IN	_	25	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	21	nmod	_	_
26	responsible	responsible	JJ	JJ	_	25	amod	_	_
27	for	for	IN	IN	_	31	case	_	_
28	germline	germline	NN	NN	_	31	compound	_	_
29	C	c	NN	NN	_	31	compound	_	_
30	epsilon	epsilon	NN	NN	_	31	compound	_	_
31	transcription	transcription	NN	NN	_	26	nmod	_	_
32	in	in	IN	IN	_	39	case	_	_
33	a	a	DT	DT	_	39	det	_	_
34	human	human	JJ	JJ	_	39	amod	_	_
35	Burkitt	burkitt	NN	NN	_	39	compound	_	_
36	lymphoma	lymphoma	NN	NN	_	39	compound	_	_
37	B	b	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	31	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	DND39	dnd39	NN	NN	_	39	appos	_	_
42	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	IL-4	il-4	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	anti-CD40	anti-cd40	JJ	JJ	_	5	amod	_	_
5	mAb	mab	NN	NN	_	2	conj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	activation	activation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	phosphatidylinositol	phosphatidylinositol	NN	NN	_	10	compound	_	_
10	3-kinase	3-kinase	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PI3-kinase	pi3-kinase	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	7	punct	_	_
15	translocation	translocation	NN	NN	_	7	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	zeta	zeta	NN	NN	_	19	compound	_	_
19	isoform	isoform	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	protein	protein	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	C	c	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	7	punct	_	_
25	and	and	CC	CC	_	7	cc	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	expression	expression	NN	NN	_	7	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	such	such	JJ	JJ	_	3	amod	_	_
3	events	event	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	abrogated	abrogate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	treatment	treatment	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	LY294002	ly294002	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	inhibitor	inhibitor	NN	NN	_	9	appos	_	_
14	of	of	IN	IN	_	15	case	_	_
15	PI3-kinase	pi3-kinase	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NAC	nac	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	antioxidant	antioxidant	NN	NN	_	4	appos	_	_
12	,	,	,	,	_	4	punct	_	_
13	decreased	decrease	VBD	VBD	_	0	root	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	caused	cause	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	IL-4	il-4	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	anti-CD40	anti-cd40	JJ	JJ	_	22	amod	_	_
22	mAb	mab	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	or	or	CC	CC	_	19	cc	_	_
25	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
26	combination	combination	NN	NN	_	19	conj	_	_
27	.	.	.	.	_	13	punct	_	_

1	NAC	nac	NN	NN	_	4	nsubj	_	_
2	was	be	VBD	VBD	_	4	cop	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	effective	effective	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	diminishing	diminish	VBG	VBG	_	4	advcl	_	_
7	germline	germline	NN	NN	_	10	compound	_	_
8	C	c	NN	NN	_	10	compound	_	_
9	epsilon	epsilon	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	potency	potency	NN	NN	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	higher	higher	JJR	JJR	_	4	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cultures	culture	NNS	NNS	_	16	nmod	_	_
19	costimulated	costimulate	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	IL-4	il-4	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	anti-CD40	anti-cd40	JJ	JJ	_	24	amod	_	_
24	mAb	mab	NN	NN	_	21	conj	_	_
25	than	than	IN	IN	_	27	case	_	_
26	in	in	IN	IN	_	27	case	_	_
27	those	those	DT	DT	_	16	nmod	_	_
28	stimulated	stimulate	VBN	VBN	_	27	acl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	IL-4	il-4	NN	NN	_	28	nmod	_	_
31	alone	alone	RB	RB	_	30	advmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	IL-4	il-4	NN	NN	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	ligation	ligation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CD40	cd40	NN	NN	_	7	nmod	_	_
10	induce	induce	VBP	VBP	_	3	ccomp	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	via	via	IN	IN	_	18	case	_	_
15	at	at	IN	IN	_	18	advmod	_	_
16	least	least	JJS	JJS	_	15	mwe	_	_
17	a	a	DT	DT	_	18	det	_	_
18	mechanism	mechanism	NN	NN	_	10	nmod	_	_
19	dependent	dependent	JJ	JJ	_	18	amod	_	_
20	on	on	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	PI3-kinase	pi3-kinase	NN	NN	_	23	compound	_	_
23	pathway	pathway	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	3	cc	_	_
25	suggest	suggest	VBP	VBP	_	3	conj	_	_
26	that	that	IN	IN	_	33	mark	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	33	nsubj	_	_
29	sensitive	sensitive	JJ	JJ	_	28	amod	_	_
30	to	to	TO	TO	_	31	case	_	_
31	NAC	nac	NN	NN	_	29	nmod	_	_
32	may	may	MD	MD	_	33	aux	_	_
33	play	play	VB	VB	_	25	ccomp	_	_
34	a	a	DT	DT	_	35	det	_	_
35	role	role	NN	NN	_	33	dobj	_	_
36	in	in	IN	IN	_	37	mark	_	_
37	regulating	regulate	VBG	VBG	_	33	advcl	_	_
38	germline	germline	NN	NN	_	41	compound	_	_
39	C	c	NN	NN	_	41	compound	_	_
40	epsilon	epsilon	NN	NN	_	41	compound	_	_
41	transcription	transcription	NN	NN	_	37	dobj	_	_
42	.	.	.	.	_	3	punct	_	_

1	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	nsubj	_	_
2	from	from	IN	IN	_	3	case	_	_
3	individuals	individual	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	filarial	filarial	JJ	JJ	_	6	amod	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	disease	disease	NN	NN	_	3	nmod	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	increased	increase	VBN	VBN	_	0	root	_	_
10	transendothelial	transendothelial	JJ	JJ	_	11	amod	_	_
11	migration	migration	NN	NN	_	9	dobj	_	_
12	in	in	FW	FW	_	11	amod	_	_
13	vitro	vitro	FW	FW	_	12	dep	_	_
14	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	in	in	FW	FW	_	5	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	transendothelial	transendothelial	JJ	JJ	_	5	amod	_	_
5	migration	migration	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	circulating	circulate	VBG	VBG	_	10	amod	_	_
8	filarial	filarial	JJ	JJ	_	10	amod	_	_
9	antigen-specific	antigen-specific	JJ	JJ	_	10	amod	_	_
10	T-cells	t-cell	NNS	NNS	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	examined	examine	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Wuchereria	wuchereria	FW	FW	_	16	compound	_	_
15	banerofti	banerofti	FW	FW	_	16	compound	_	_
16	infection	infection	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Circulating	circulate	VBG	VBG	_	2	amod	_	_
2	T-cells	t-cell	NNS	NNS	_	12	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	individuals	individual	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	filaria-induced	filaria-induced	JJ	JJ	_	8	amod	_	_
7	lymphatic	lymphatic	JJ	JJ	_	8	amod	_	_
8	pathology	pathology	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LP	lp	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	had	have	VBD	VBD	_	0	root	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	greater	greater	JJR	JJR	_	15	amod	_	_
15	migration	migration	NN	NN	_	12	dobj	_	_
16	through	through	IN	IN	_	19	case	_	_
17	unstimulated	unstimulated	JJ	JJ	_	19	amod	_	_
18	HUVEC	huvec	NN	NN	_	19	compound	_	_
19	monolayers	monolayer	NNS	NNS	_	15	nmod	_	_
20	than	than	IN	IN	_	21	dep	_	_
21	did	do	VBD	VBD	_	15	dep	_	_
22	T-cells	t-cell	NNS	NNS	_	21	nsubj	_	_
23	from	from	IN	IN	_	29	case	_	_
24	asymptomatic	asymptomatic	JJ	JJ	_	25	amod	_	_
25	infected	infected	JJ	JJ	_	29	amod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	MF	mf	NN	NN	_	25	dep	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	individuals	individual	NNS	NNS	_	22	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	P	p	NN	NN	_	29	dep	_	_
32	=	=	JJ	JJ	_	31	amod	_	_
33	0.04	0.04	CD	CD	_	32	dep	_	_
34	)	)	-RRB-	-RRB-	_	31	punct	_	_
35	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	31	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	MF	mf	NN	NN	_	6	compound	_	_
6	individuals	individual	NNS	NNS	_	2	nmod	_	_
7	where	where	WRB	WRB	_	11	advmod	_	_
8	no	no	DT	DT	_	9	neg	_	_
9	effect	effect	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	seen	see	VBN	VBN	_	6	acl:relcl	_	_
12	,	,	,	,	_	31	punct	_	_
13	transendothelial	transendothelial	JJ	JJ	_	14	amod	_	_
14	migration	migration	NN	NN	_	31	nsubj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	48-hr	48-hr	JJ	JJ	_	20	amod	_	_
17	filarial	filarial	JJ	JJ	_	20	amod	_	_
18	antigen	antigen	NN	NN	_	20	compound	_	_
19	stimulated	stimulated	JJ	JJ	_	20	amod	_	_
20	T-cells	t-cell	NNS	NNS	_	14	nmod	_	_
21	from	from	IN	IN	_	23	case	_	_
22	LP	lp	NN	NN	_	23	compound	_	_
23	individuals	individual	NNS	NNS	_	20	nmod	_	_
24	was	be	VBD	VBD	_	31	cop	_	_
25	significantly	significantly	RB	RB	_	31	advmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	P	p	NN	NN	_	25	dep	_	_
28	=	=	JJ	JJ	_	27	amod	_	_
29	0.01	0.01	CD	CD	_	28	dep	_	_
30	)	)	-RRB-	-RRB-	_	27	punct	_	_
31	greater	greater	JJR	JJR	_	0	root	_	_
32	than	than	IN	IN	_	33	case	_	_
33	migration	migration	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	48-hr	48-hr	JJ	JJ	_	37	amod	_	_
36	media-stimulated	media-stimulated	JJ	JJ	_	37	amod	_	_
37	T-cells	t-cell	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	31	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	six	six	CD	CD	_	13	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	seven	seven	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	examined	examine	VBN	VBN	_	5	acl	_	_
7	,	,	,	,	_	13	punct	_	_
8	inhibition	inhibition	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	VLA-4/VCAM-1	vla-4/vcam-1	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	8	nmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	19	case	_	_
15	greater	greater	JJR	JJR	_	17	advmod	_	_
16	than	than	IN	IN	_	17	advmod	_	_
17	50	50	CD	CD	_	18	dep	_	_
18	%	%	NN	NN	_	19	dep	_	_
19	inhibition	inhibition	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transendothelial	transendothelial	JJ	JJ	_	22	amod	_	_
22	migration	migration	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	T-cells	t-cell	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	predominant	predominant	JJ	JJ	_	4	amod	_	_
3	E2F	e2f	NN	NN	_	4	compound	_	_
4	complex	complex	NN	NN	_	14	nsubj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	haemopoietic	haemopoietic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	in	in	IN	IN	_	13	case	_	_
12	AML	aml	NN	NN	_	13	compound	_	_
13	blasts	blast	NNS	NNS	_	9	conj	_	_
14	contains	contain	VBZ	VBZ	_	0	root	_	_
15	E2F-4	e2f-4	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	DP-1	dp-1	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	p130	p130	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	E2F	e2f	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	thought	think	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	play	play	VB	VB	_	8	xcomp	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	control	control	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	cycle	cycle	NN	NN	_	20	compound	_	_
20	progression	progression	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	now	now	RB	RB	_	2	advmod	_	_
4	also	also	RB	RB	_	2	advmod	_	_
5	increasing	increase	VBG	VBG	_	6	amod	_	_
6	evidence	evidence	NN	NN	_	2	nsubj	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	some	some	DT	DT	_	10	det	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	members	member	NNS	NNS	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	act	act	VB	VB	_	6	ccomp	_	_
13	as	as	IN	IN	_	14	case	_	_
14	oncogenes	oncogene	NNS	NNS	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	tumour	tumour	NN	NN	_	18	compound	_	_
17	suppressor	suppressor	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	characterization	characterization	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	haemopoietic	haemopoietic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	acute	acute	JJ	JJ	_	18	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
14	leukaemia	leukaemia	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	AML	aml	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	blasts	blast	NNS	NNS	_	10	conj	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	thus	thus	RB	RB	_	21	advmod	_	_
21	give	give	VB	VB	_	0	root	_	_
22	an	a	DT	DT	_	23	det	_	_
23	insight	insight	NN	NN	_	21	dobj	_	_
24	to	to	TO	TO	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	molecular	molecular	JJ	JJ	_	27	amod	_	_
27	mechanisms	mechanism	NNS	NNS	_	23	nmod	_	_
28	governing	govern	VBG	VBG	_	27	acl	_	_
29	proliferation	proliferation	NN	NN	_	28	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	leukaemogenesis	leukaemogenesis	NN	NN	_	29	conj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	these	these	DT	DT	_	34	det	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	21	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	analysed	analyse	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	E2F-DNA	e2f-dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	constituent	constituent	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	5	conj	_	_
14	found	find	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	complexes	complex	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	primary	primary	JJ	JJ	_	22	amod	_	_
21	haemopoietic	haemopoietic	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	various	various	JJ	JJ	_	25	amod	_	_
25	lineages	lineage	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	studied	study	VBD	VBD	_	0	root	_	_
4	blasts	blast	NNS	NNS	_	3	dobj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	18	18	CD	CD	_	7	nummod	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	acute	acute	JJ	JJ	_	11	amod	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	leukaemia	leukaemia	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AML	aml	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	3	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	electromobility	electromobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	14	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSA	emsa	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	a	a	DT	DT	_	12	det	_	_
9	single	single	JJ	JJ	_	12	amod	_	_
10	E2F-DNA	e2f-dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	monocytes	monocyte	NNS	NNS	_	17	conj	_	_
23	which	which	WDT	WDT	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	shown	show	VBN	VBN	_	14	ccomp	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	contain	contain	VB	VB	_	25	xcomp	_	_
28	E2F-4	e2f-4	NN	NN	_	27	dobj	_	_
29	,	,	,	,	_	28	punct	_	_
30	DP-1	dp-1	NN	NN	_	28	conj	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	p130	p130	NN	NN	_	28	conj	_	_
33	,	,	,	,	_	14	punct	_	_
34	indicating	indicate	VBG	VBG	_	14	xcomp	_	_
35	that	that	IN	IN	_	40	mark	_	_
36	all	all	DT	DT	_	39	det	_	_
37	quiescent	quiescent	JJ	JJ	_	39	amod	_	_
38	haemopoietic	haemopoietic	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	40	nsubj	_	_
40	have	have	VBP	VBP	_	34	ccomp	_	_
41	the	the	DT	DT	_	43	det	_	_
42	same	same	JJ	JJ	_	43	amod	_	_
43	complex	complex	NN	NN	_	40	dobj	_	_
44	.	.	.	.	_	14	punct	_	_

1	Examination	examination	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	18	18	CD	CD	_	5	nummod	_	_
4	AML	aml	NN	NN	_	5	compound	_	_
5	samples	sample	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	EMSA	emsa	NNS	NNS	_	1	nmod	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	E2F	e2f	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	no	no	DT	DT	_	17	neg	_	_
16	gross	gross	JJ	JJ	_	17	amod	_	_
17	abnormalities	abnormality	NNS	NNS	_	19	nsubjpass	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	detected	detect	VBN	VBN	_	8	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	E2F-4/p130	e2f-4/p130	NN	NN	_	3	compound	_	_
3	complex	complex	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	representative	representative	JJ	JJ	_	8	amod	_	_
8	samples	sample	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	all	all	DT	DT	_	12	det	_	_
11	FAB	fab	NN	NN	_	12	compound	_	_
12	types	type	NNS	NNS	_	8	nmod	_	_
13	analysed	analyse	VBN	VBN	_	8	acl	_	_
14	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	abnormalities	abnormality	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	E2F	e2f	NN	NN	_	5	compound	_	_
5	function	function	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	unlikely	unlikely	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	play	play	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	13	det	_	_
11	primary	primary	JJ	JJ	_	13	amod	_	_
12	pathogenic	pathogenic	JJ	JJ	_	11	dep	_	_
13	role	role	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	AML	aml	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	4	case	_	_
3	azelastine	azelastine	NN	NN	_	4	compound	_	_
4	hydrochloride	hydrochloride	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	1	nmod	_	_
9	involved	involve	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	generation	generation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nitric	nitric	JJ	JJ	_	16	amod	_	_
16	oxide	oxide	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	influence	influence	NN	NN	_	29	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	anti-allergy	anti-allergy	JJ	JJ	_	6	amod	_	_
6	agent	agent	NN	NN	_	2	nmod	_	_
7	azelastine	azelastine	NN	NN	_	8	compound	_	_
8	hydrochloride	hydrochloride	NN	NN	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Azeptin	azeptin	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	on	on	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	2	nmod	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	generation	generation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	cytokines	cytokine	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	nitric	nitric	JJ	JJ	_	24	amod	_	_
24	oxide	oxide	NN	NN	_	21	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	NO	no	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	investigated	investigate	VBN	VBN	_	0	root	_	_
30	in	in	IN	IN	_	32	case	_	_
31	various	various	JJ	JJ	_	32	amod	_	_
32	kinds	kind	NNS	NNS	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	human	human	JJ	JJ	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	mouse	mouse	NN	NN	_	34	conj	_	_
37	cells	cell	NNS	NNS	_	34	dep	_	_
38	.	.	.	.	_	29	punct	_	_

1	Azeptin	azeptin	NN	NN	_	3	nsubj	_	_
2	dose-dependently	dose-dependently	RB	RB	_	3	advmod	_	_
3	suppressed	suppress	VBD	VBD	_	0	root	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	DNA	dna	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	protein	protein	NN	NN	_	5	conj	_	_
8	synthesis	synthesis	NN	NN	_	5	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	gingival	gingival	JJ	JJ	_	12	amod	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HF	hf	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	suppressed	suppress	VBD	VBD	_	3	conj	_	_
19	blastogenesis	blastogenesis	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
23	blood	blood	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PBL	pbl	NNS	NNS	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	3	punct	_	_

1	Generation	generation	NN	NN	_	27	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	tumor	tumor	NN	NN	_	5	compound	_	_
4	necrosis	necrosis	NN	NN	_	5	compound	_	_
5	factor-alpha	factor-alpha	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	interleukin	interleukin	NN	NN	_	8	compound	_	_
8	1-beta	1-beta	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	12	amod	_	_
11	colony-stimulating	colony-stimulating	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	5	conj	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	interleukin-6	interleukin-6	NN	NN	_	5	conj	_	_
15	from	from	IN	IN	_	19	case	_	_
16	10(-5)	10(-5)	CD	CD	_	17	nummod	_	_
17	M	m	NN	NN	_	18	nmod:npmod	_	_
18	Azeptin-treated	azeptin-treated	JJ	JJ	_	19	amod	_	_
19	PBL	pbl	NNS	NNS	_	1	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	monocytes	monocyte	NNS	NNS	_	19	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	HM	hm	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	decreased	decrease	VBN	VBN	_	0	root	_	_
28	to	to	TO	TO	_	32	case	_	_
29	approximately	approximately	RB	RB	_	32	advmod	_	_
30	1/3	1/3	CD	CD	_	32	compound	_	_
31	to	to	TO	TO	_	32	dep	_	_
32	2/3	2/3	CD	CD	_	27	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	control	control	NN	NN	_	36	compound	_	_
36	levels	level	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	27	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	14	nmod	_	_
3	with	with	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	decreased	decrease	VBN	VBN	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	generation	generation	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	each	each	DT	DT	_	11	det	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	14	nsubjpass	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	less	less	RBR	RBR	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	presence	presence	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	10(-5)	10(-5)	CD	CD	_	20	compound	_	_
20	M	m	NN	NN	_	21	amod	_	_
21	Azeptin	azeptin	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	both	both	CC	CC	_	9	cc:preconj	_	_
5	inducible	inducible	JJ	JJ	_	9	amod	_	_
6	nitric	nitric	JJ	JJ	_	9	amod	_	_
7	oxide	oxide	NN	NN	_	9	compound	_	_
8	synthase-mRNA	synthase-mrna	NN	NN	_	9	compound	_	_
9	level	level	NN	NN	_	18	nsubjpass	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NO	no	NN	NN	_	12	compound	_	_
12	generation	generation	NN	NN	_	9	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	mouse	mouse	NN	NN	_	16	compound	_	_
15	peritoneal	peritoneal	JJ	JJ	_	16	amod	_	_
16	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	suppressed	suppress	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	22	case	_	_
20	10(-5)	10(-5)	CD	CD	_	21	compound	_	_
21	M	m	NN	NN	_	22	amod	_	_
22	Azeptin	azeptin	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	18	punct	_	_

1	Being	be	VBG	VBG	_	2	cop	_	_
2	compatible	compatible	JJ	JJ	_	0	root	_	_
3	with	with	IN	IN	_	5	case	_	_
4	those	those	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	Azeptin	azeptin	NN	NN	_	12	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	10(-5)	10(-5)	CD	CD	_	10	nummod	_	_
10	M	m	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	suppressed	suppress	VBD	VBD	_	2	parataxis	_	_
13	activation	activation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	PBL	pbl	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	HM	hm	NNS	NNS	_	18	conj	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	HF	hf	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	appear	appear	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	indicate	indicate	VB	VB	_	3	xcomp	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	suppression	suppression	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cytokine	cytokine	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	NO	no	NN	NN	_	12	compound	_	_
12	generation	generation	NN	NN	_	7	conj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	Azeptin	azeptin	NN	NN	_	7	nmod	_	_
15	results	result	VBZ	VBZ	_	5	ccomp	_	_
16	at	at	IN	IN	_	15	advmod	_	_
17	least	least	JJS	JJS	_	16	mwe	_	_
18	partially	partially	RB	RB	_	15	advmod	_	_
19	from	from	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	inhibition	inhibition	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Physical	physical	JJ	JJ	_	2	amod	_	_
2	interactions	interaction	NNS	NNS	_	8	nsubj	_	_
3	between	between	IN	IN	_	4	case	_	_
4	Ets	ets	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	4	conj	_	_
7	proteins	protein	NNS	NNS	_	4	dep	_	_
8	play	play	VBP	VBP	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	cooperative	cooperative	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	21	compound	_	_
20	virus	virus	NN	NN	_	21	compound	_	_
21	enhancer	enhancer	NN	NN	_	15	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	elements	element	NNS	NNS	_	10	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	many	many	JJ	JJ	_	9	amod	_	_
7	inducible	inducible	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	4	nmod	_	_
10	contain	contain	VBP	VBP	_	0	root	_	_
11	adjacent	adjacent	JJ	JJ	_	10	dobj	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	overlapping	overlap	VBG	VBG	_	15	amod	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	11	conj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	dep	_	_
18	Ets	ets	NN	NN	_	11	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	18	conj	_	_
21	families	family	NNS	NNS	_	18	dep	_	_
22	of	of	IN	IN	_	24	case	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	arrays	array	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Ets	ets	NN	NN	_	6	conj	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	6	dep	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	present	present	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	enhancers	enhancer	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	immunodeficiency	immunodeficiency	NN	NN	_	21	compound	_	_
20	viruses	virus	NNS	NNS	_	21	compound	_	_
21	types	type	NNS	NNS	_	16	nmod	_	_
22	1	1	CD	CD	_	21	dep	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	2	2	CD	CD	_	21	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	HIV-1	hiv-1	NN	NN	_	21	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	HIV-2	hiv-2	NN	NN	_	26	conj	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	,	,	,	,	_	12	punct	_	_
31	suggesting	suggest	VBG	VBG	_	12	xcomp	_	_
32	that	that	IN	IN	_	40	mark	_	_
33	this	this	DT	DT	_	34	det	_	_
34	pattern	pattern	NN	NN	_	40	nsubj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
37	protein	protein	NN	NN	_	39	compound	_	_
38	binding	binding	NN	NN	_	39	compound	_	_
39	sites	site	NNS	NNS	_	34	nmod	_	_
40	reflects	reflect	VBZ	VBZ	_	31	ccomp	_	_
41	an	a	DT	DT	_	44	det	_	_
42	evolutionarily	evolutionarily	RB	RB	_	43	advmod	_	_
43	conserved	conserve	VBN	VBN	_	44	amod	_	_
44	mechanism	mechanism	NN	NN	_	40	dobj	_	_
45	for	for	IN	IN	_	46	mark	_	_
46	regulating	regulate	VBG	VBG	_	44	acl	_	_
47	inducible	inducible	JJ	JJ	_	50	amod	_	_
48	T-cell	t-cell	NN	NN	_	50	compound	_	_
49	gene	gene	NN	NN	_	50	compound	_	_
50	expression	expression	NN	NN	_	46	dobj	_	_
51	that	that	WDT	WDT	_	54	nsubjpass	_	_
52	has	have	VBZ	VBZ	_	54	aux	_	_
53	been	be	VBN	VBN	_	54	auxpass	_	_
54	co-opted	co-opt	VBN	VBN	_	50	acl:relcl	_	_
55	during	during	IN	IN	_	57	case	_	_
56	HIV	hiv	NN	NN	_	57	compound	_	_
57	evolution	evolution	NN	NN	_	54	nmod	_	_
58	.	.	.	.	_	12	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	findings	finding	NNS	NNS	_	20	nmod	_	_
4	,	,	,	,	_	20	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	20	nsubj	_	_
8	by	by	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	15	nmod	_	_
10	Ets	ets	NN	NN	_	15	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	10	conj	_	_
13	proteins	protein	NNS	NNS	_	10	dep	_	_
14	cooperatively	cooperatively	RB	RB	_	15	advmod	_	_
15	regulate	regulate	VBP	VBP	_	7	acl:relcl	_	_
16	inducible	inducible	JJ	JJ	_	19	amod	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	15	dobj	_	_
20	remained	remain	VBD	VBD	_	0	root	_	_
21	unknown	unknown	JJ	JJ	_	20	xcomp	_	_
22	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	studies	study	NNS	NNS	_	10	nmod	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	report	report	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	physical	physical	JJ	JJ	_	13	amod	_	_
13	interaction	interaction	NN	NN	_	10	dobj	_	_
14	between	between	IN	IN	_	16	case	_	_
15	multiple	multiple	JJ	JJ	_	16	amod	_	_
16	Ets	ets	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	16	conj	_	_
19	proteins	protein	NNS	NNS	_	16	dep	_	_
20	both	both	CC	CC	_	16	dep	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vitro	vitro	FW	FW	_	20	dep	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	in	in	IN	IN	_	29	case	_	_
25	activated	activate	VBN	VBN	_	29	amod	_	_
26	normal	normal	JJ	JJ	_	29	amod	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	20	conj	_	_
30	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Ets	ets	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	Ets	ets	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	C-terminal	c-terminal	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	Rel	rel	NN	NN	_	20	compound	_	_
19	homology	homology	NN	NN	_	20	compound	_	_
20	domains	domain	NNS	NNS	_	15	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Ets-NF-kappaB/NFAT	ets-nf-kappab/nfat	NN	NN	_	6	compound	_	_
6	interaction	interaction	NN	NN	_	7	nsubj	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	presence	presence	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	9	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	both	both	DT	DT	_	16	det	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	as	as	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	abolished	abolish	VBN	VBN	_	7	advcl	_	_
22	by	by	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	DNA	dna	NN	NN	_	26	compound	_	_
25	intercalating	intercalating	NN	NN	_	26	compound	_	_
26	agents	agent	NNS	NNS	_	21	nmod	_	_
27	propidium	propidium	NN	NN	_	28	compound	_	_
28	iodide	iodide	NN	NN	_	26	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	ethidium	ethidium	NN	NN	_	31	compound	_	_
31	bromide	bromide	NN	NN	_	28	conj	_	_
32	and	and	CC	CC	_	21	cc	_	_
33	enhanced	enhance	VBN	VBN	_	21	conj	_	_
34	by	by	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	presence	presence	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	synthetic	synthetic	JJ	JJ	_	39	amod	_	_
39	oligonucleotides	oligonucleotide	NNS	NNS	_	36	nmod	_	_
40	containing	contain	VBG	VBG	_	39	acl	_	_
41	binding	bind	VBG	VBG	_	42	amod	_	_
42	sites	site	NNS	NNS	_	40	dobj	_	_
43	for	for	IN	IN	_	44	case	_	_
44	Ets	ets	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	NF-kappaB	nf-kappab	NN	NN	_	47	compound	_	_
47	proteins	protein	NNS	NNS	_	44	conj	_	_
48	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	dominant-negative	dominant-negative	JJ	JJ	_	3	amod	_	_
3	mutant	mutant	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	p50	p50	NN	NN	_	3	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
9	DNA	dna	NN	NN	_	8	dobj	_	_
10	but	but	CC	CC	_	8	cc	_	_
11	fails	fail	VBZ	VBZ	_	8	conj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	interact	interact	VB	VB	_	11	xcomp	_	_
14	with	with	IN	IN	_	16	case	_	_
15	Ets	ets	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
18	the	the	DT	DT	_	20	det	_	_
19	synergistic	synergistic	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	HIV-1	hiv-1	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	HIV-2	hiv-2	NN	NN	_	23	conj	_	_
26	enhancers	enhancer	NNS	NNS	_	23	dep	_	_
27	by	by	IN	IN	_	28	case	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	17	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	p50	p50	NN	NN	_	28	dep	_	_
31	+	+	CC	CC	_	30	cc	_	_
32	p65	p65	NN	NN	_	30	conj	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	and	and	CC	CC	_	28	cc	_	_
35	Ets-1	ets-1	NN	NN	_	28	conj	_	_
36	,	,	,	,	_	17	punct	_	_
37	suggesting	suggest	VBG	VBG	_	17	advcl	_	_
38	that	that	IN	IN	_	47	mark	_	_
39	physical	physical	JJ	JJ	_	40	amod	_	_
40	interaction	interaction	NN	NN	_	47	nsubjpass	_	_
41	between	between	IN	IN	_	42	case	_	_
42	Ets	ets	NN	NN	_	40	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	NF-kappaB	nf-kappab	NN	NN	_	45	compound	_	_
45	proteins	protein	NNS	NNS	_	42	conj	_	_
46	is	be	VBZ	VBZ	_	47	auxpass	_	_
47	required	require	VBN	VBN	_	37	ccomp	_	_
48	for	for	IN	IN	_	51	case	_	_
49	the	the	DT	DT	_	51	det	_	_
50	transcriptional	transcriptional	JJ	JJ	_	51	amod	_	_
51	activity	activity	NN	NN	_	47	nmod	_	_
52	of	of	IN	IN	_	54	case	_	_
53	the	the	DT	DT	_	54	dep	_	_
54	HIV-1	hiv-1	NN	NN	_	51	nmod	_	_
55	and	and	CC	CC	_	54	cc	_	_
56	HIV-2	hiv-2	NN	NN	_	54	conj	_	_
57	enhancers	enhancer	NNS	NNS	_	54	dep	_	_
58	.	.	.	.	_	17	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	evolutionarily	evolutionarily	RB	RB	_	9	advmod	_	_
9	conserved	conserve	VBN	VBN	_	11	amod	_	_
10	physical	physical	JJ	JJ	_	11	amod	_	_
11	interactions	interaction	NNS	NNS	_	18	nsubj	_	_
12	between	between	IN	IN	_	13	case	_	_
13	Ets	ets	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-kappaB/NFAT	nf-kappab/nfat	NN	NN	_	13	conj	_	_
16	proteins	protein	NNS	NNS	_	13	dep	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	important	important	JJ	JJ	_	6	ccomp	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	regulating	regulate	VBG	VBG	_	18	advcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	inducible	inducible	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	viruses	virus	NNS	NNS	_	26	conj	_	_
29	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	interactions	interaction	NNS	NNS	_	3	nsubj	_	_
3	represent	represent	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	target	target	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	development	development	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	novel	novel	JJ	JJ	_	12	amod	_	_
12	immunosuppressive	immunosuppressive	JJ	JJ	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	antiviral	antiviral	JJ	JJ	_	12	conj	_	_
15	therapies	therapy	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	3	punct	_	_

1	Nucleolin	nucleolin	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	one	one	CD	CD	_	4	nummod	_	_
4	component	component	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	dep	_	_
7	B	b	NN	NN	_	10	compound	_	_
8	cell-specific	cell-specific	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	switch	switch	NN	NN	_	15	compound	_	_
13	region	region	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	10	conj	_	_
16	,	,	,	,	_	15	punct	_	_
17	LR1	lr1	NN	NN	_	15	appos	_	_
18	.	.	.	.	_	4	punct	_	_

1	LR1	lr1	NN	NN	_	10	nsubj	_	_
2	is	be	VBZ	VBZ	_	10	cop	_	_
3	a	a	DT	DT	_	10	det	_	_
4	B	b	NN	NN	_	5	nmod:npmod	_	_
5	cell-specific	cell-specific	JJ	JJ	_	10	amod	_	_
6	,	,	,	,	_	5	punct	_	_
7	sequence-specific	sequence-specific	JJ	JJ	_	5	dep	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	0	root	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	regulates	regulate	VBZ	VBZ	_	10	acl:relcl	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	LR1	lr1	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	binds	bind	VBZ	VBZ	_	0	root	_	_
4	Ig	ig	NN	NN	_	6	compound	_	_
5	heavy	heavy	JJ	JJ	_	6	amod	_	_
6	chain	chain	NN	NN	_	9	compound	_	_
7	switch	switch	NN	NN	_	9	compound	_	_
8	region	region	NN	NN	_	9	compound	_	_
9	sequences	sequence	NNS	NNS	_	3	dobj	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	function	function	VB	VB	_	3	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	class	class	NN	NN	_	16	compound	_	_
15	switch	switch	NN	NN	_	16	compound	_	_
16	recombination	recombination	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	LR1	lr1	NN	NN	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	two	two	CD	CD	_	4	nummod	_	_
4	polypeptides	polypeptide	NNS	NNS	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	of	of	IN	IN	_	8	case	_	_
7	106	106	CD	CD	_	8	nummod	_	_
8	kDa	kda	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	45	45	CD	CD	_	11	nummod	_	_
11	kDa	kda	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	2	punct	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	here	here	RB	RB	_	16	advmod	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	report	report	VBP	VBP	_	2	conj	_	_
17	that	that	IN	IN	_	24	mark	_	_
18	the	the	DT	DT	_	20	det	_	_
19	106-kDa	106-kda	JJ	JJ	_	20	amod	_	_
20	component	component	NN	NN	_	24	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	LR1	lr1	NN	NN	_	20	nmod	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	nucleolin	nucleolin	NN	NN	_	16	ccomp	_	_
25	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	11	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	initially	initially	RB	RB	_	5	advmod	_	_
5	made	make	VBN	VBN	_	2	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	microsequence	microsequence	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	verified	verify	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	showing	show	VBG	VBG	_	11	advcl	_	_
14	that	that	IN	IN	_	21	mark	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	i	i	LS	LS	_	21	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	LR1-DNA	lr1-dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	21	nsubj	_	_
21	increased	increase	VBD	VBD	_	13	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	transfected	transfect	VBN	VBN	_	24	acl	_	_
26	with	with	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	nucleolin	nucleolin	NN	NN	_	31	compound	_	_
29	cDNA	cdna	NN	NN	_	31	compound	_	_
30	expression	expression	NN	NN	_	31	compound	_	_
31	construct	construct	NN	NN	_	25	nmod	_	_
32	;	;	:	:	_	21	punct	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	ii	ii	LS	LS	_	40	dep	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	LR1-DNA	lr1-dna	NN	NN	_	38	compound	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	40	nsubjpass	_	_
39	was	be	VBD	VBD	_	40	auxpass	_	_
40	recognized	recognize	VBN	VBN	_	21	conj	_	_
41	by	by	IN	IN	_	42	case	_	_
42	antibodies	antibody	NNS	NNS	_	40	nmod	_	_
43	raised	raise	VBN	VBN	_	42	acl	_	_
44	against	against	IN	IN	_	47	case	_	_
45	recombinant	recombinant	JJ	JJ	_	47	amod	_	_
46	human	human	JJ	JJ	_	47	amod	_	_
47	nucleolin	nucleolin	NN	NN	_	43	nmod	_	_
48	;	;	:	:	_	21	punct	_	_
49	and	and	CC	CC	_	21	cc	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	iii	iii	LS	LS	_	67	dep	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	in	in	IN	IN	_	55	case	_	_
54	B	b	NN	NN	_	55	compound	_	_
55	cells	cell	NNS	NNS	_	67	nmod	_	_
56	transfected	transfect	VBN	VBN	_	55	acl	_	_
57	with	with	IN	IN	_	61	case	_	_
58	epitope-tagged	epitope-tagged	JJ	JJ	_	61	amod	_	_
59	nucleolin	nucleolin	NN	NN	_	61	compound	_	_
60	expression	expression	NN	NN	_	61	compound	_	_
61	constructs	construct	NNS	NNS	_	56	nmod	_	_
62	,	,	,	,	_	67	punct	_	_
63	the	the	DT	DT	_	65	det	_	_
64	LR1-DNA	lr1-dna	JJ	JJ	_	65	amod	_	_
65	complex	complex	NN	NN	_	67	nsubjpass	_	_
66	was	be	VBD	VBD	_	67	auxpass	_	_
67	recognized	recognize	VBN	VBN	_	21	conj	_	_
68	by	by	IN	IN	_	71	case	_	_
69	the	the	DT	DT	_	71	det	_	_
70	anti-tag	anti-tag	JJ	JJ	_	71	amod	_	_
71	antibody	antibody	NN	NN	_	67	nmod	_	_
72	.	.	.	.	_	11	punct	_	_

1	Nucleolin	nucleolin	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	abundant	abundant	JJ	JJ	_	6	amod	_	_
5	nucleolar	nucleolar	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	0	root	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	believed	believe	VBN	VBN	_	6	acl:relcl	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	play	play	VB	VB	_	9	xcomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	rDNA	rdna	NN	NN	_	11	nmod	_	_
16	transcription	transcription	NN	NN	_	15	dep	_	_
17	or	or	CC	CC	_	15	cc	_	_
18	organization	organization	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	or	or	CC	CC	_	15	cc	_	_
21	rRNA	rrna	NN	NN	_	22	compound	_	_
22	processing	processing	NN	NN	_	15	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Homology	homology	NN	NN	_	7	nsubj	_	_
2	between	between	IN	IN	_	3	case	_	_
3	nucleolin	nucleolin	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	histone	histone	NN	NN	_	6	compound	_	_
6	H1	h1	NN	NN	_	3	conj	_	_
7	suggests	suggest	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	nucleolin	nucleolin	NN	NN	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	alter	alter	VB	VB	_	7	dep	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	organization	organization	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	cycle	cycle	NN	NN	_	19	compound	_	_
19	controls	control	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	11	punct	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	nucleolin	nucleolin	NN	NN	_	24	compound	_	_
24	component	component	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	LR1	lr1	NN	NN	_	24	nmod	_	_
27	may	may	MD	MD	_	29	aux	_	_
28	therefore	therefore	RB	RB	_	29	advmod	_	_
29	function	function	VB	VB	_	11	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	organize	organize	VB	VB	_	29	xcomp	_	_
32	switch	switch	NN	NN	_	33	compound	_	_
33	regions	region	NNS	NNS	_	31	dobj	_	_
34	before	before	IN	IN	_	41	nmod	_	_
35	,	,	,	,	_	41	punct	_	_
36	during	during	IN	IN	_	41	conj	_	_
37	,	,	,	,	_	41	punct	_	_
38	or	or	CC	CC	_	41	cc	_	_
39	after	after	IN	IN	_	41	conj	_	_
40	switch	switch	NN	NN	_	41	compound	_	_
41	recombination	recombination	NN	NN	_	31	nmod	_	_
42	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	demonstration	demonstration	NN	NN	_	18	nsubj	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	nucleolin	nucleolin	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	component	component	NN	NN	_	2	ccomp	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
12	complex	complex	NN	NN	_	7	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
15	switch	switch	NN	NN	_	17	compound	_	_
16	region	region	NN	NN	_	17	compound	_	_
17	sequences	sequence	NNS	NNS	_	14	dobj	_	_
18	suggests	suggest	VBZ	VBZ	_	0	root	_	_
19	that	that	IN	IN	_	26	mark	_	_
20	the	the	DT	DT	_	23	det	_	_
21	G-rich	g-rich	JJ	JJ	_	23	amod	_	_
22	switch	switch	NN	NN	_	23	compound	_	_
23	regions	region	NNS	NNS	_	26	nsubj	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	have	have	VB	VB	_	26	aux	_	_
26	evolved	evolve	VBN	VBN	_	18	ccomp	_	_
27	from	from	IN	IN	_	28	case	_	_
28	rDNA	rdna	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	18	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	neutrophil	neutrophil	NN	NN	_	3	compound	_	_
3	elastase	elastase	NN	NN	_	5	nsubj	_	_
4	proteolytically	proteolytically	RB	RB	_	5	advmod	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	platelet	platelet	NN	NN	_	8	compound	_	_
8	integrin	integrin	NN	NN	_	5	dobj	_	_
9	alphaIIbbeta3	alphaiibbeta3	NN	NN	_	8	dep	_	_
10	through	through	IN	IN	_	11	case	_	_
11	cleavage	cleavage	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	carboxyl	carboxyl	NN	NN	_	15	compound	_	_
15	terminus	terminus	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	alphaIIb	alphaiib	NN	NN	_	21	compound	_	_
19	subunit	subunit	NN	NN	_	21	compound	_	_
20	heavy	heavy	JJ	JJ	_	21	amod	_	_
21	chain	chain	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	potentiation	potentiation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	platelet	platelet	NN	NN	_	7	compound	_	_
7	aggregation	aggregation	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	2	compound	_	_
2	elastase	elastase	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	NE	ne	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	cathepsin	cathepsin	NN	NN	_	8	compound	_	_
8	G	g	NN	NN	_	2	conj	_	_
9	are	be	VBP	VBP	_	12	cop	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	serine	serine	NN	NN	_	12	compound	_	_
12	proteinases	proteinase	NNS	NNS	_	0	root	_	_
13	released	release	VBN	VBN	_	12	acl	_	_
14	concomitantly	concomitantly	RB	RB	_	13	advmod	_	_
15	by	by	IN	IN	_	18	case	_	_
16	stimulated	stimulate	VBN	VBN	_	18	amod	_	_
17	polymorphonuclear	polymorphonuclear	JJ	JJ	_	18	amod	_	_
18	neutrophils	neutrophil	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	while	while	IN	IN	_	11	mark	_	_
6	NE	ne	NN	NN	_	11	nsubj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	itself	itself	PRP	PRP	_	11	nmod	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	activate	activate	VB	VB	_	17	advcl	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	platelets	platelet	NNS	NNS	_	11	dobj	_	_
14	,	,	,	,	_	17	punct	_	_
15	it	it	PRP	PRP	_	17	nsubj	_	_
16	strongly	strongly	RB	RB	_	17	advmod	_	_
17	enhances	enhance	VBZ	VBZ	_	3	ccomp	_	_
18	the	the	DT	DT	_	20	det	_	_
19	weak	weak	JJ	JJ	_	20	amod	_	_
20	aggregation	aggregation	NN	NN	_	17	dobj	_	_
21	induced	induce	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	threshold	threshold	NN	NN	_	25	compound	_	_
25	concentration	concentration	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	cathepsin	cathepsin	NN	NN	_	28	compound	_	_
28	G	g	NN	NN	_	25	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	threshold	threshold	NN	NN	_	25	dep	_	_
31	of	of	IN	IN	_	33	case	_	_
32	cathepsin	cathepsin	NN	NN	_	33	compound	_	_
33	G	g	NN	NN	_	30	nmod	_	_
34	)	)	-RRB-	-RRB-	_	30	punct	_	_
35	(	(	-LRB-	-LRB-	_	38	punct	_	_
36	Renesto	Renesto	NNP	NNP	_	38	compound	_	_
37	,	,	,	,	_	38	punct	_	_
38	P.	P.	NNP	NNP	_	3	dep	_	_
39	,	,	,	,	_	38	punct	_	_
40	and	and	CC	CC	_	38	cc	_	_
41	Chignard	Chignard	NNP	NNP	_	43	compound	_	_
42	,	,	,	,	_	43	punct	_	_
43	M.	M.	NNP	NNP	_	38	conj	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	1993	1993	CD	CD	_	38	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	Blood	Blood	NNP	NNP	_	38	dep	_	_
48	82	82	CD	CD	_	47	nummod	_	_
49	,	,	,	,	_	38	punct	_	_
50	139-144	139-144	CD	CD	_	38	amod	_	_
51	)	)	-RRB-	-RRB-	_	38	punct	_	_
52	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	delineate	delineate	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	11	det	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	8	dobj	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	this	this	DT	DT	_	16	det	_	_
15	potentiation	potentiation	NN	NN	_	16	compound	_	_
16	process	process	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	main	main	JJ	JJ	_	3	amod	_	_
3	pieces	piece	NNS	NNS	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	data	datum	NNS	NNS	_	3	nmod	_	_
6	prompted	prompt	VBD	VBD	_	0	root	_	_
7	us	we	PRP	PRP	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	focus	focus	VB	VB	_	6	xcomp	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	platelet	platelet	NN	NN	_	17	compound	_	_
16	fibrinogen	fibrinogen	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	alphaIIbbeta3	alphaiibbeta3	NN	NN	_	21	compound	_	_
21	integrin	integrin	NN	NN	_	17	appos	_	_
22	.	.	.	.	_	6	punct	_	_

1	First	first	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	previous	previous	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	this	this	DT	DT	_	8	det	_	_
8	integrin	integrin	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	particularly	particularly	RB	RB	_	12	advmod	_	_
12	prone	prone	JJ	JJ	_	6	xcomp	_	_
13	to	to	TO	TO	_	15	case	_	_
14	proteolytic	proteolytic	JJ	JJ	_	15	amod	_	_
15	regulation	regulation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	function	function	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Second	second	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	potentiating	potentiating	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	21	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NE	ne	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	threshold	threshold	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	cathepsin	cathepsin	NN	NN	_	18	compound	_	_
16	G-induced	g-induced	JJ	JJ	_	18	amod	_	_
17	platelet	platelet	NN	NN	_	18	compound	_	_
18	aggregation	aggregation	NN	NN	_	13	nmod	_	_
19	was	be	VBD	VBD	_	21	cop	_	_
20	strictly	strictly	RB	RB	_	21	advmod	_	_
21	dependent	dependent	JJ	JJ	_	4	ccomp	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	presence	presence	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	exogenous	exogenous	JJ	JJ	_	27	amod	_	_
27	fibrinogen	fibrinogen	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	flow	flow	NN	NN	_	4	compound	_	_
3	cytometry	cytometry	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	1	punct	_	_
6	NE	ne	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	1	parataxis	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	trigger	trigger	VB	VB	_	8	xcomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	time-dependent	time-dependent	JJ	JJ	_	13	amod	_	_
13	binding	binding	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	PAC-1	pac-1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	AP-5	ap-5	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	two	two	CD	CD	_	21	nummod	_	_
20	monoclonal	monoclonal	JJ	JJ	_	21	amod	_	_
21	antibodies	antibody	NNS	NNS	_	15	appos	_	_
22	specific	specific	JJ	JJ	_	21	amod	_	_
23	for	for	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	activated	activate	VBN	VBN	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	ligand-occupied	ligand-occupied	JJ	JJ	_	25	conj	_	_
28	conformers	conformer	NNS	NNS	_	22	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	alphaIIbbeta3	alphaiibbeta3	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	potentiated	potentiated	JJ	JJ	_	5	amod	_	_
5	aggregation	aggregation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	result	result	VB	VB	_	7	xcomp	_	_
10	from	from	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	capacity	capacity	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	platelets	platelet	NNS	NNS	_	13	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	bind	bind	VB	VB	_	13	acl	_	_
18	fibrinogen	fibrinogen	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	7	punct	_	_

1	Indeed	indeed	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	combination	combination	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NE	ne	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	threshold	threshold	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	cathepsin	cathepsin	NN	NN	_	11	compound	_	_
11	G	g	NN	NN	_	8	nmod	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	binding	binding	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	PAC-1	pac-1	NN	NN	_	14	nmod	_	_
17	approximately	approximately	RB	RB	_	18	advmod	_	_
18	5.5-fold	5.5-fold	RB	RB	_	12	nmod	_	_
19	over	over	IN	IN	_	18	case	_	_
20	basal	basal	JJ	JJ	_	21	amod	_	_
21	values	value	NNS	NNS	_	18	dep	_	_
22	measured	measure	VBN	VBN	_	21	acl	_	_
23	on	on	IN	IN	_	25	case	_	_
24	nontreated	nontreated	JJ	JJ	_	25	amod	_	_
25	platelets	platelet	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	12	punct	_	_
27	whereas	whereas	IN	IN	_	30	mark	_	_
28	this	this	DT	DT	_	29	det	_	_
29	binding	binding	NN	NN	_	30	nsubj	_	_
30	raised	raise	VBD	VBD	_	12	advcl	_	_
31	only	only	RB	RB	_	34	advmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	approximately	approximately	RB	RB	_	34	advmod	_	_
34	3-fold	3-fold	RB	RB	_	30	nmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	threshold	threshold	NN	NN	_	30	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	cathepsin	cathepsin	NN	NN	_	40	compound	_	_
39	G-stimulated	g-stimulated	JJ	JJ	_	40	amod	_	_
40	platelets	platelet	NNS	NNS	_	36	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	p	p	NN	NN	_	30	dep	_	_
43	&lt;	&lt;	JJR	JJR	_	42	dep	_	_
44	0.05	0.05	CD	CD	_	43	dep	_	_
45	)	)	-RRB-	-RRB-	_	42	punct	_	_
46	.	.	.	.	_	12	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	28	nmod	_	_
3	,	,	,	,	_	28	punct	_	_
4	phosphatidic	phosphatidic	JJ	JJ	_	6	amod	_	_
5	acid	acid	NN	NN	_	6	compound	_	_
6	accumulation	accumulation	NN	NN	_	28	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	pleckstrin	pleckstrin	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	calcium	calcium	NN	NN	_	13	compound	_	_
13	mobilization	mobilization	NN	NN	_	6	conj	_	_
14	produced	produce	VBN	VBN	_	6	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	combination	combination	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	NE	ne	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	threshold	threshold	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	cathepsin	cathepsin	NN	NN	_	24	compound	_	_
24	G	g	NN	NN	_	21	nmod	_	_
25	were	be	VBD	VBD	_	28	cop	_	_
26	not	not	RB	RB	_	28	neg	_	_
27	significantly	significantly	RB	RB	_	28	advmod	_	_
28	different	different	JJ	JJ	_	0	root	_	_
29	from	from	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	28	nmod	_	_
31	measured	measure	VBN	VBN	_	30	acl	_	_
32	with	with	IN	IN	_	33	case	_	_
33	threshold	threshold	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	cathepsin	cathepsin	NN	NN	_	36	compound	_	_
36	G	g	NN	NN	_	33	nmod	_	_
37	alone	alone	RB	RB	_	33	advmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	p	p	NN	NN	_	28	dep	_	_
40	&gt;	&gt;	JJR	JJR	_	39	dep	_	_
41	0.05	0.05	CD	CD	_	40	dep	_	_
42	)	)	-RRB-	-RRB-	_	39	punct	_	_
43	,	,	,	,	_	28	punct	_	_
44	indicating	indicate	VBG	VBG	_	28	advcl	_	_
45	that	that	IN	IN	_	54	mark	_	_
46	the	the	DT	DT	_	51	det	_	_
47	phospholipase	phospholipase	NN	NN	_	51	compound	_	_
48	C/protein	c/protein	NN	NN	_	51	compound	_	_
49	kinase	kinase	NN	NN	_	51	compound	_	_
50	C	c	NN	NN	_	51	compound	_	_
51	pathway	pathway	NN	NN	_	54	nsubjpass	_	_
52	is	be	VBZ	VBZ	_	54	auxpass	_	_
53	not	not	RB	RB	_	54	neg	_	_
54	involved	involve	VBN	VBN	_	44	ccomp	_	_
55	in	in	IN	IN	_	57	case	_	_
56	the	the	DT	DT	_	57	det	_	_
57	potentiation	potentiation	NN	NN	_	54	nmod	_	_
58	of	of	IN	IN	_	59	case	_	_
59	aggregation	aggregation	NN	NN	_	57	nmod	_	_
60	.	.	.	.	_	28	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	foregoing	foregoing	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	27	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	as	as	RB	RB	_	3	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	the	the	DT	DT	_	9	det	_	_
9	requirement	requirement	NN	NN	_	3	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	catalytically	catalytically	RB	RB	_	12	advmod	_	_
12	active	active	JJ	JJ	_	13	amod	_	_
13	NE	ne	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	trigger	trigger	VB	VB	_	9	acl	_	_
16	alphaIIbbeta3	alphaiibbeta3	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	potentiate	potentiate	VB	VB	_	15	conj	_	_
20	threshold	threshold	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	cathepsin	cathepsin	NN	NN	_	25	compound	_	_
23	G-initiated	g-initiated	JJ	JJ	_	25	amod	_	_
24	platelet	platelet	NN	NN	_	25	compound	_	_
25	aggregation	aggregation	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	3	punct	_	_
27	led	lead	VBD	VBD	_	0	root	_	_
28	us	we	PRP	PRP	_	27	dobj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	examine	examine	VB	VB	_	27	xcomp	_	_
31	whether	whether	IN	IN	_	38	mark	_	_
32	the	the	DT	DT	_	33	det	_	_
33	structure	structure	NN	NN	_	38	nsubjpass	_	_
34	of	of	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	integrin	integrin	NN	NN	_	33	nmod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	affected	affect	VBN	VBN	_	30	ccomp	_	_
39	by	by	IN	IN	_	40	case	_	_
40	NE	ne	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	27	punct	_	_

1	Immunoblot	immunoblot	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	flow	flow	NN	NN	_	4	compound	_	_
4	cytometry	cytometry	NN	NN	_	1	conj	_	_
5	analysis	analysis	NN	NN	_	1	dep	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	limited	limited	JJ	JJ	_	9	amod	_	_
9	proteolysis	proteolysis	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	carboxyl	carboxyl	NN	NN	_	13	compound	_	_
13	terminus	terminus	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	alphaIIb	alphaiib	NN	NN	_	19	compound	_	_
17	subunit	subunit	NN	NN	_	19	compound	_	_
18	heavy	heavy	JJ	JJ	_	19	amod	_	_
19	chain	chain	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	alphaIIbH	alphaiibh	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	6	punct	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	judged	judge	VBN	VBN	_	6	advcl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	disappearance	disappearance	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	epitope	epitope	NN	NN	_	28	nmod	_	_
32	for	for	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	monoclonal	monoclonal	JJ	JJ	_	36	amod	_	_
35	antibody	antibody	JJ	JJ	_	36	amod	_	_
36	PMI-1	pmi-1	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Mass	mass	JJ	JJ	_	3	amod	_	_
2	spectrometry	spectrometry	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	16	nsubj	_	_
4	performed	perform	VBN	VBN	_	3	acl	_	_
5	on	on	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	synthetic	synthetic	JJ	JJ	_	8	amod	_	_
8	peptide	peptide	NN	NN	_	4	nmod	_	_
9	mapping	map	VBG	VBG	_	8	acl	_	_
10	over	over	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cleavage	cleavage	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	alphaIIbH	alphaiibh	NN	NN	_	13	nmod	_	_
16	predicted	predict	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	site	site	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	proteolysis	proteolysis	NN	NN	_	18	nmod	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	located	located	JJ	JJ	_	16	advcl	_	_
23	between	between	IN	IN	_	24	case	_	_
24	Val837	val837	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Asp838	asp838	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	16	punct	_	_

1	Treatment	treatment	NN	NN	_	17	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	NE	ne	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	ATP-depleted	atp-depleted	JJ	JJ	_	6	amod	_	_
6	platelets	platelet	NNS	NNS	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	Chinese	chinese	JJ	JJ	_	11	amod	_	_
9	hamster	hamster	NN	NN	_	11	compound	_	_
10	ovary	ovary	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	conj	_	_
12	expressing	express	VBG	VBG	_	11	acl	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	recombinant	recombinant	NN	NN	_	15	compound	_	_
15	alphaIIbbeta3	alphaiibbeta3	NN	NN	_	12	dobj	_	_
16	clearly	clearly	RB	RB	_	17	advmod	_	_
17	established	establish	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	activation	activation	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	integrin	integrin	NN	NN	_	19	nmod	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	independent	independent	JJ	JJ	_	17	ccomp	_	_
25	of	of	IN	IN	_	28	case	_	_
26	signal	signal	NN	NN	_	28	compound	_	_
27	transduction	transduction	NN	NN	_	28	compound	_	_
28	events	event	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	was	be	VBD	VBD	_	31	cop	_	_
31	concomitant	concomitant	JJ	JJ	_	24	conj	_	_
32	with	with	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	proteolysis	proteolysis	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	alphaIIbH	alphaiibh	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SLAP-130	slap-130	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	an	a	DT	DT	_	8	det	_	_
7	SLP-76-associated	slp-76-associated	JJ	JJ	_	8	amod	_	_
8	substrate	substrate	NN	NN	_	4	appos	_	_
9	of	of	IN	IN	_	17	case	_	_
10	the	the	DT	DT	_	17	det	_	_
11	T	t	NN	NN	_	17	compound	_	_
12	cell	cell	NN	NN	_	17	compound	_	_
13	antigen	antigen	NN	NN	_	17	compound	_	_
14	receptor-stimulated	receptor-stimulated	JJ	JJ	_	17	amod	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	kinases	kinase	NNS	NNS	_	8	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	work	work	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	SLP-76	slp-76	NN	NN	_	13	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	11	det	_	_
9	Grb2-associated	grb2-associated	JJ	JJ	_	11	amod	_	_
10	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	6	appos	_	_
12	,	,	,	,	_	6	punct	_	_
13	augments	augment	VBZ	VBZ	_	4	ccomp	_	_
14	Interleukin-2	interleukin-2	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	dobj	_	_
17	when	when	WRB	WRB	_	18	advmod	_	_
18	overexpressed	overexpress	VBN	VBN	_	13	advcl	_	_
19	in	in	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	Jurkat	jurkat	NN	NN	_	24	compound	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	regions	region	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	SLP-76	slp-76	NN	NN	_	4	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	mediate	mediate	VBP	VBP	_	4	acl:relcl	_	_
9	protein-protein	protein-protein	JJ	JJ	_	10	amod	_	_
10	interactions	interaction	NNS	NNS	_	8	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	molecules	molecule	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	suggesting	suggest	VBG	VBG	_	3	advcl	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	SLP-76-associated	slp-76-associated	JJ	JJ	_	21	amod	_	_
21	proteins	protein	NNS	NNS	_	23	nsubj	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	function	function	VBP	VBP	_	18	ccomp	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	regulate	regulate	VB	VB	_	23	xcomp	_	_
26	signal	signal	NN	NN	_	27	compound	_	_
27	transduction	transduction	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	cloning	cloning	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	SLAP-130	slap-130	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	SLP-76-associated	slp-76-associated	JJ	JJ	_	12	amod	_	_
12	phosphoprotein	phosphoprotein	NN	NN	_	8	appos	_	_
13	of	of	IN	IN	_	15	case	_	_
14	130	130	CD	CD	_	15	nummod	_	_
15	kDa	kda	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	SLAP-130	slap-130	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
7	cell-specific	cell-specific	JJ	JJ	_	2	ccomp	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	associates	associate	VBZ	VBZ	_	7	conj	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	SH2	sh2	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	SLP-76	slp-76	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	SLAP-130	slap-130	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	substrate	substrate	NN	NN	_	4	ccomp	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	T	t	NN	NN	_	16	compound	_	_
13	cell	cell	NN	NN	_	16	compound	_	_
14	antigen	antigen	NN	NN	_	16	compound	_	_
15	receptor-induced	receptor-induced	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	9	nmod	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	16	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	Interestingly	interestingly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	find	find	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	in	in	IN	IN	_	7	case	_	_
7	contrast	contrast	NN	NN	_	14	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	SLP-76	slp-76	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	overexpression	overexpression	NN	NN	_	14	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	SLAP-130	slap-130	NN	NN	_	11	nmod	_	_
14	diminishes	diminish	VBZ	VBZ	_	4	ccomp	_	_
15	T	t	NN	NN	_	19	compound	_	_
16	cell	cell	NN	NN	_	19	compound	_	_
17	antigen	antigen	NN	NN	_	19	compound	_	_
18	receptor-induced	receptor-induced	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	14	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	interleukin-2	interleukin-2	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	Jurkat	jurkat	NN	NN	_	27	compound	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	19	nmod	_	_
28	and	and	CC	CC	_	14	cc	_	_
29	interferes	interfere	VBZ	VBZ	_	14	conj	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	augmentation	augmentation	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	interleukin-2	interleukin-2	NN	NN	_	35	compound	_	_
35	promoter	promoter	NN	NN	_	36	compound	_	_
36	activity	activity	NN	NN	_	32	nmod	_	_
37	seen	see	VBN	VBN	_	32	acl	_	_
38	when	when	WRB	WRB	_	41	advmod	_	_
39	SLP-76	slp-76	NN	NN	_	41	nsubjpass	_	_
40	is	be	VBZ	VBZ	_	41	auxpass	_	_
41	overexpressed	overexpress	VBN	VBN	_	37	advcl	_	_
42	in	in	IN	IN	_	44	case	_	_
43	these	these	DT	DT	_	44	det	_	_
44	cells	cell	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	SLP-76	slp-76	NN	NN	_	6	nsubj	_	_
6	recruits	recruit	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	negative	negative	JJ	JJ	_	9	amod	_	_
9	regulator	regulator	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	SLAP-130	slap-130	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	as	as	RB	RB	_	9	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	positive	positive	JJ	JJ	_	17	amod	_	_
17	regulators	regulator	NNS	NNS	_	9	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	transduction	transduction	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	genetic	genetic	JJ	JJ	_	2	dep	_	_
4	system	system	NN	NN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	isolate	isolate	VB	VB	_	4	acl	_	_
7	a	a	DT	DT	_	10	det	_	_
8	dominant	dominant	JJ	JJ	_	10	amod	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	effector	effector	NN	NN	_	6	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Oct-2	oct-2	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	revealed	reveal	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	interactions	interaction	NNS	NNS	_	10	nsubj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	play	play	VBP	VBP	_	4	ccomp	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	regulation	regulation	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	eukaryotic	eukaryotic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	isolate	isolate	VB	VB	_	0	root	_	_
3	cDNA	cdna	NN	NN	_	4	compound	_	_
4	clones	clone	NNS	NNS	_	2	dobj	_	_
5	that	that	WDT	WDT	_	7	nsubj	_	_
6	dominantly	dominantly	RB	RB	_	7	advmod	_	_
7	inhibit	inhibit	VBP	VBP	_	4	acl:relcl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	DNA-binding	dna-binding	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Oct-2	oct-2	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	chosen	choose	VBN	VBN	_	12	acl	_	_
15	as	as	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	representative	representative	JJ	JJ	_	18	amod	_	_
18	factor	factor	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	2	punct	_	_
20	we	we	PRP	PRP	_	22	nsubj	_	_
21	have	have	VBP	VBP	_	22	aux	_	_
22	developed	develop	VBN	VBN	_	2	parataxis	_	_
23	a	a	DT	DT	_	26	det	_	_
24	novel	novel	JJ	JJ	_	26	amod	_	_
25	screening	screening	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	employs	employ	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	7	det	_	_
4	Escherichia	escherichia	FW	FW	_	7	compound	_	_
5	coli	coli	FW	FW	_	7	compound	_	_
6	tester	tester	NN	NN	_	7	compound	_	_
7	strain	strain	NN	NN	_	2	dobj	_	_
8	carrying	carry	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	modified	modify	VBN	VBN	_	12	amod	_	_
11	lac	lac	NN	NN	_	12	compound	_	_
12	operon	operon	NN	NN	_	8	dobj	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	8	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	with	with	IN	IN	_	23	mark	_	_
19	the	the	DT	DT	_	22	det	_	_
20	lac	lac	NN	NN	_	22	compound	_	_
21	operator	operator	NN	NN	_	22	compound	_	_
22	sequence	sequence	NN	NN	_	23	nsubj	_	_
23	replaced	replace	VBN	VBN	_	2	advcl	_	_
24	by	by	IN	IN	_	27	case	_	_
25	an	a	DT	DT	_	27	det	_	_
26	octamer	octamer	NN	NN	_	27	compound	_	_
27	sequence	sequence	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	Oct-2	oct-2	NN	NN	_	7	nsubj	_	_
2	expressed	express	VBN	VBN	_	1	acl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	tester	tester	NN	NN	_	6	compound	_	_
6	strain	strain	NN	NN	_	2	nmod	_	_
7	represses	repress	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	reporter	reporter	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	changes	change	VBZ	VBZ	_	7	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phenotype	phenotype	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cell	cell	NN	NN	_	17	nmod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	Lac+	lac+	JJ	JJ	_	15	nmod	_	_
23	to	to	TO	TO	_	24	case	_	_
24	Lac-	lac-	JJ	JJ	_	15	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Introduction	introduction	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	cDNA	cdna	NN	NN	_	6	compound	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	library	library	NN	NN	_	1	nmod	_	_
7	prepared	prepare	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	7	nmod	_	_
13	into	into	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	Oct-2-harboring	oct-2-harboring	JJ	JJ	_	17	amod	_	_
16	tester	tester	NN	NN	_	17	compound	_	_
17	strain	strain	NN	NN	_	1	nmod	_	_
18	allowed	allow	VBD	VBD	_	0	root	_	_
19	selection	selection	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	three	three	CD	CD	_	23	nummod	_	_
22	Lac+	lac+	JJ	JJ	_	23	amod	_	_
23	clones	clone	NNS	NNS	_	19	nmod	_	_
24	out	out	RP	RP	_	29	dep	_	_
25	of	of	IN	IN	_	29	case	_	_
26	1	1	CD	CD	_	29	nummod	_	_
27	x	x	CC	CC	_	26	cc	_	_
28	10(5)	10(5)	CD	CD	_	26	conj	_	_
29	transformants	transformant	NNS	NNS	_	19	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	One	one	CD	CD	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	them	they	PRP	PRP	_	1	nmod	_	_
4	,	,	,	,	_	1	punct	_	_
5	hT86	ht86	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	5	punct	_	_
7	encoding	encode	VBG	VBG	_	5	acl	_	_
8	a	a	DT	DT	_	12	det	_	_
9	putative	putative	JJ	JJ	_	12	amod	_	_
10	zinc	zinc	NN	NN	_	12	compound	_	_
11	finger	finger	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	7	dobj	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	derepress	derepress	VB	VB	_	14	xcomp	_	_
17	beta-galactosidase	beta-galactosidase	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	Oct-2-harboring	oct-2-harboring	JJ	JJ	_	23	amod	_	_
22	tester	tester	NN	NN	_	23	compound	_	_
23	strain	strain	NN	NN	_	18	nmod	_	_
24	at	at	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	transcriptional	transcriptional	JJ	JJ	_	27	amod	_	_
27	level	level	NN	NN	_	16	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	gel	gel	NN	NN	_	5	compound	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	hT86	ht86	NN	NN	_	8	nsubj	_	_
8	attenuated	attenuate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	intensity	intensity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	retarded	retard	VBN	VBN	_	14	amod	_	_
14	band	band	NN	NN	_	10	nmod	_	_
15	composed	compose	VBN	VBN	_	14	acl	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	octamer	octamer	NN	NN	_	19	compound	_	_
19	probe	probe	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Oct-2	oct-2	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	8	punct	_	_
23	suggesting	suggest	VBG	VBG	_	8	advcl	_	_
24	a	a	DT	DT	_	27	det	_	_
25	dominant	dominant	JJ	JJ	_	27	amod	_	_
26	negative	negative	JJ	JJ	_	27	amod	_	_
27	effect	effect	NN	NN	_	23	dobj	_	_
28	on	on	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	DNA-binding	dna-binding	JJ	JJ	_	31	amod	_	_
31	activity	activity	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	Oct-2	oct-2	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	strategy	strategy	NN	NN	_	5	nsubj	_	_
3	described	describe	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	provides	provide	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	new	new	JJ	JJ	_	8	amod	_	_
8	approach	approach	NN	NN	_	5	dobj	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	studying	study	VBG	VBG	_	8	acl	_	_
11	protein-protein	protein-protein	JJ	JJ	_	12	amod	_	_
12	interactions	interaction	NNS	NNS	_	10	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	govern	govern	VBP	VBP	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	complex	complex	JJ	JJ	_	17	amod	_	_
17	regulation	regulation	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	phosphoinositide	phosphoinositide	NN	NN	_	6	compound	_	_
6	3-kinase	3-kinase	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	T-cell	t-cell	NN	NN	_	10	compound	_	_
9	antigen	antigen	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	A	a	DT	DT	_	5	det	_	_
4	delicate	delicate	JJ	JJ	_	5	amod	_	_
5	balance	balance	NN	NN	_	15	nsubj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	positive	positive	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	negative	negative	JJ	JJ	_	7	conj	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	7	dep	_	_
12	during	during	IN	IN	_	14	case	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	5	nmod	_	_
15	determines	determine	VBZ	VBZ	_	1	dep	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	specificity	specificity	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	magnitude	magnitude	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Phosphoinositide	phosphoinositide	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	8	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	PI	pi	NN	NN	_	5	compound	_	_
5	3-kinase	3-kinase	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	diverse	diverse	JJ	JJ	_	12	amod	_	_
12	set	set	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	receptors	receptor	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	determine	determine	VBP	VBP	_	14	acl:relcl	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	12	punct	_	_
20	including	include	VBG	VBG	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	T-cell	t-cell	NN	NN	_	24	compound	_	_
23	antigen	antigen	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	12	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	TCR	tcr	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	24	punct	_	_
29	the	the	DT	DT	_	32	det	_	_
30	costimulatory	costimulatory	JJ	JJ	_	32	amod	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	CD28	cd28	NN	NN	_	24	conj	_	_
33	,	,	,	,	_	24	punct	_	_
34	and	and	CC	CC	_	24	cc	_	_
35	negative	negative	JJ	JJ	_	36	amod	_	_
36	regulators	regulator	NNS	NNS	_	24	conj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	T-cell	t-cell	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	36	nmod	_	_
40	such	such	JJ	JJ	_	42	case	_	_
41	as	as	IN	IN	_	40	mwe	_	_
42	CTLA-4	ctla-4	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	8	punct	_	_

1	PI	pi	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	regulated	regulate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	haematopoietic	haematopoietic	JJ	JJ	_	9	amod	_	_
9	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	determine	determine	VBP	VBP	_	9	acl:relcl	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	differentiation	differentiation	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	lymphocyte	lymphocyte	NN	NN	_	16	compound	_	_
16	proliferation	proliferation	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	PI	pi	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	6	nsubj	_	_
3	can	can	MD	MD	_	6	aux	_	_
4	thus	thus	RB	RB	_	6	advmod	_	_
5	dynamically	dynamically	RB	RB	_	6	advmod	_	_
6	influence	influence	VB	VB	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	outcome	outcome	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	reactions	reaction	NNS	NNS	_	8	nmod	_	_
13	at	at	IN	IN	_	15	case	_	_
14	various	various	JJ	JJ	_	15	amod	_	_
15	stages	stage	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	importance	importance	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	PI	pi	NN	NN	_	11	compound	_	_
11	3-kinase	3-kinase	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	TCR-directed	tcr-directed	JJ	JJ	_	15	amod	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	8	nmod	_	_
16	using	use	VBG	VBG	_	6	xcomp	_	_
17	activated	activate	VBN	VBN	_	16	dobj	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	inhibitory	inhibitory	JJ	JJ	_	17	conj	_	_
20	versions	version	NNS	NNS	_	17	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	PI	pi	NN	NN	_	23	compound	_	_
23	3-kinase	3-kinase	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Certain	certain	JJ	JJ	_	4	amod	_	_
4	aspects	aspect	NNS	NNS	_	23	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	TCR	tcr	NN	NN	_	7	compound	_	_
7	responses	response	NNS	NNS	_	4	nmod	_	_
8	such	such	JJ	JJ	_	11	case	_	_
9	as	as	IN	IN	_	8	mwe	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	AP1	ap1	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	serum	serum	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	16	conj	_	_
21	were	be	VBD	VBD	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	affected	affect	VBN	VBN	_	1	dep	_	_
24	by	by	IN	IN	_	25	case	_	_
25	expression	expression	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	mutant	mutant	JJ	JJ	_	29	amod	_	_
29	forms	form	NNS	NNS	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	PI	pi	NN	NN	_	32	compound	_	_
32	3-kinase	3-kinase	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	however	however	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	PI	pi	NN	NN	_	8	compound	_	_
8	3-kinase	3-kinase	NN	NN	_	10	nsubj	_	_
9	profoundly	profoundly	RB	RB	_	10	advmod	_	_
10	influenced	influence	VBD	VBD	_	2	dep	_	_
11	the	the	DT	DT	_	13	det	_	_
12	transactivation	transactivation	NN	NN	_	13	compound	_	_
13	capacity	capacity	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	'	'	``	``	_	21	punct	_	_
16	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
17	factor	factor	NN	NN	_	21	compound	_	_
18	of	of	IN	IN	_	21	amod	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	'	'	''	''	_	21	punct	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	NF-AT	nf-at	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	elicited	elicit	VBN	VBN	_	21	acl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	TCR	tcr	NN	NN	_	26	nmod	_	_
30	:	:	:	:	_	10	punct	_	_
31	expression	expression	NN	NN	_	39	nsubj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	an	a	DT	DT	_	35	det	_	_
34	activated	activated	JJ	JJ	_	35	amod	_	_
35	form	form	NN	NN	_	31	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	PI	pi	NN	NN	_	38	compound	_	_
38	3-kinase	3-kinase	NN	NN	_	35	nmod	_	_
39	inhibited	inhibit	VBD	VBD	_	10	dep	_	_
40	TCR-mediated	tcr-mediated	JJ	JJ	_	42	amod	_	_
41	NF-AT	nf-at	NN	NN	_	42	compound	_	_
42	responses	response	NNS	NNS	_	39	dobj	_	_
43	,	,	,	,	_	39	punct	_	_
44	whereas	whereas	IN	IN	_	55	mark	_	_
45	expression	expression	NN	NN	_	55	nsubj	_	_
46	of	of	IN	IN	_	50	case	_	_
47	a	a	DT	DT	_	50	det	_	_
48	dominant	dominant	JJ	JJ	_	50	amod	_	_
49	negative	negative	JJ	JJ	_	50	amod	_	_
50	mutant	mutant	NN	NN	_	45	nmod	_	_
51	of	of	IN	IN	_	53	case	_	_
52	PI	pi	NN	NN	_	53	compound	_	_
53	3-kinase	3-kinase	NN	NN	_	50	nmod	_	_
54	potently	potently	RB	RB	_	55	advmod	_	_
55	enhanced	enhance	VBD	VBD	_	39	advcl	_	_
56	TCR-controlled	tcr-controlled	JJ	JJ	_	58	amod	_	_
57	NF-AT	nf-at	NN	NN	_	58	compound	_	_
58	induction	induction	NN	NN	_	55	dobj	_	_
59	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PI	pi	NN	NN	_	5	compound	_	_
5	3-kinase	3-kinase	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	14	case	_	_
10	previously	previously	RB	RB	_	11	advmod	_	_
11	identified	identify	VBN	VBN	_	14	amod	_	_
12	PI	pi	NN	NN	_	14	compound	_	_
13	3-kinase	3-kinase	NN	NN	_	14	compound	_	_
14	effectors	effector	NNS	NNS	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	such	such	JJ	JJ	_	20	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	24	det	_	_
23	positive	positive	JJ	JJ	_	24	amod	_	_
24	regulator	regulator	NN	NN	_	20	appos	_	_
25	of	of	IN	IN	_	27	case	_	_
26	PI	pi	NN	NN	_	27	compound	_	_
27	3-kinase	3-kinase	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	or	or	CC	CC	_	20	cc	_	_
30	the	the	DT	DT	_	32	det	_	_
31	GTPase	gtpase	NN	NN	_	32	compound	_	_
32	Rac	rac	NN	NN	_	20	conj	_	_
33	,	,	,	,	_	8	punct	_	_
34	and	and	CC	CC	_	8	cc	_	_
35	are	be	VBP	VBP	_	37	cop	_	_
36	therefore	therefore	RB	RB	_	37	advmod	_	_
37	likely	likely	JJ	JJ	_	8	conj	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	involve	involve	VB	VB	_	37	xcomp	_	_
40	a	a	DT	DT	_	48	det	_	_
41	novel	novel	JJ	JJ	_	48	amod	_	_
42	,	,	,	,	_	41	punct	_	_
43	as	as	IN	IN	_	44	case	_	_
44	yet	yet	RB	RB	_	45	advmod	_	_
45	unknown	unknown	JJ	JJ	_	41	dep	_	_
46	,	,	,	,	_	48	punct	_	_
47	effector	effector	NN	NN	_	48	compound	_	_
48	molecule	molecule	NN	NN	_	39	dobj	_	_
49	.	.	.	.	_	8	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	establish	establish	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	PI	pi	NN	NN	_	8	compound	_	_
8	3-kinase	3-kinase	NN	NN	_	14	nsubj	_	_
9	can	can	MD	MD	_	14	aux	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	positively	positively	RB	RB	_	12	advmod	_	_
12	and	and	CC	CC	_	14	advmod	_	_
13	negatively	negatively	RB	RB	_	12	advmod	_	_
14	regulate	regulate	VB	VB	_	5	ccomp	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	function	function	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	5	punct	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	uncover	uncover	VBP	VBP	_	5	conj	_	_
20	a	a	DT	DT	_	23	det	_	_
21	previously	previously	RB	RB	_	22	advmod	_	_
22	unrecognized	unrecognized	JJ	JJ	_	23	amod	_	_
23	function	function	NN	NN	_	19	dobj	_	_
24	for	for	IN	IN	_	26	case	_	_
25	PI	pi	NN	NN	_	26	compound	_	_
26	3-kinase	3-kinase	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	23	nmod	_	_
30	as	as	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	selective	selective	JJ	JJ	_	33	amod	_	_
33	negative	negative	JJ	JJ	_	34	amod	_	_
34	regulator	regulator	NN	NN	_	23	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	TCR-signalling	tcr-signalling	JJ	JJ	_	37	amod	_	_
37	events	event	NNS	NNS	_	34	nmod	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	therefore	therefore	RB	RB	_	42	advmod	_	_
40	as	as	IN	IN	_	42	case	_	_
41	a	a	DT	DT	_	42	det	_	_
42	determinant	determinant	NN	NN	_	34	conj	_	_
43	of	of	IN	IN	_	45	case	_	_
44	T-cell	t-cell	NN	NN	_	45	compound	_	_
45	homeostasis	homeostasis	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	1	punct	_	_

1	Pivotal	pivotal	JJ	JJ	_	2	amod	_	_
2	role	role	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	NFIL3/E4BP4	nfil3/e4bp4	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	interleukin	interleukin	NN	NN	_	11	compound	_	_
10	3-mediated	3-mediated	JJ	JJ	_	11	amod	_	_
11	survival	survival	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	pro-B	pro-b	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	E2A-HLF	e2a-hlf	NN	NN	_	8	compound	_	_
3	(	(	-LRB-	-LRB-	_	8	punct	_	_
4	hepatic	hepatic	JJ	JJ	_	8	amod	_	_
5	leukemia	leukemia	NN	NN	_	8	compound	_	_
6	factor	factor	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	oncoprotein	oncoprotein	NN	NN	_	34	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	generated	generate	VBN	VBN	_	8	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	pro-B	pro-b	JJ	JJ	_	13	amod	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	fusion	fusion	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	trans-activation	trans-activation	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	E2A	e2a	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	30	case	_	_
23	the	the	DT	DT	_	30	det	_	_
24	basic	basic	JJ	JJ	_	30	amod	_	_
25	region/leucine	region/leucine	NN	NN	_	30	compound	_	_
26	zipper	zipper	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	bZIP	bzip	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	domain	domain	NN	NN	_	15	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	HLF	hlf	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	8	punct	_	_
34	functions	function	VBZ	VBZ	_	0	root	_	_
35	as	as	IN	IN	_	39	case	_	_
36	an	a	DT	DT	_	39	det	_	_
37	anti-apoptotic	anti-apoptotic	JJ	JJ	_	39	amod	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factor	factor	NN	NN	_	34	nmod	_	_
40	in	in	IN	IN	_	43	case	_	_
41	leukemic	leukemic	JJ	JJ	_	43	amod	_	_
42	cell	cell	NN	NN	_	43	compound	_	_
43	transformation	transformation	NN	NN	_	34	nmod	_	_
44	.	.	.	.	_	34	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	introduced	introduce	VBN	VBN	_	15	advcl	_	_
3	into	into	IN	IN	_	10	case	_	_
4	interleukin	interleukin	NN	NN	_	10	compound	_	_
5	3	3	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-3	il-3	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	-dependent	-dependent	JJ	JJ	_	10	amod	_	_
10	mouse	mouse	NN	NN	_	2	nmod	_	_
11	pro-B	pro-b	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	10	dep	_	_
13	,	,	,	,	_	15	punct	_	_
14	E2A-HLF	e2a-hlf	NN	NN	_	15	nsubj	_	_
15	prevents	prevent	VBZ	VBZ	_	0	root	_	_
16	apoptosis	apoptosis	NN	NN	_	15	dobj	_	_
17	induced	induce	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	growth	growth	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	deprivation	deprivation	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	suggesting	suggest	VBG	VBG	_	15	advcl	_	_
24	that	that	IN	IN	_	26	mark	_	_
25	IL-3	il-3	NN	NN	_	26	nsubj	_	_
26	mediates	mediate	VBZ	VBZ	_	23	ccomp	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	survival	survival	NN	NN	_	26	dobj	_	_
29	through	through	IN	IN	_	30	case	_	_
30	activation	activation	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factor	factor	NN	NN	_	30	nmod	_	_
35	whose	whose	WP$	WP$	_	36	nmod:poss	_	_
36	activity	activity	NN	NN	_	40	nsubjpass	_	_
37	can	can	MD	MD	_	40	aux	_	_
38	be	be	VB	VB	_	40	auxpass	_	_
39	constitutively	constitutively	RB	RB	_	40	advmod	_	_
40	replaced	replace	VBN	VBN	_	34	acl:relcl	_	_
41	by	by	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	chimeric	chimeric	JJ	JJ	_	44	amod	_	_
44	oncoprotein	oncoprotein	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	considered	consider	VBD	VBD	_	0	root	_	_
3	four	four	CD	CD	_	6	nummod	_	_
4	bZIP	bzip	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	dobj	_	_
7	as	as	IN	IN	_	8	case	_	_
8	candidates	candidate	NNS	NNS	_	2	nmod	_	_
9	for	for	IN	IN	_	13	case	_	_
10	this	this	DT	DT	_	13	det	_	_
11	putative	putative	JJ	JJ	_	13	amod	_	_
12	IL-3-regulated	il-3-regulated	JJ	JJ	_	13	amod	_	_
13	factor	factor	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	each	each	DT	DT	_	18	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	15	nmod	_	_
18	binds	bind	VBZ	VBZ	_	2	dep	_	_
19	avidly	avidly	RB	RB	_	18	advmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	DNA	dna	NN	NN	_	24	compound	_	_
23	consensus	consensus	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	18	nmod	_	_
25	recognized	recognize	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	27	case	_	_
27	E2A-HLF	e2a-hlf	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	is	be	VBZ	VBZ	_	30	cop	_	_
30	related	related	JJ	JJ	_	18	conj	_	_
31	to	to	TO	TO	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	Caenorhabditis	caenorhabditis	NN	NN	_	35	compound	_	_
34	elegans	elegans	NN	NN	_	35	compound	_	_
35	CES-2	ces-2	NN	NN	_	30	nmod	_	_
36	(	(	-LRB-	-LRB-	_	40	punct	_	_
37	cell	cell	NN	NN	_	40	compound	_	_
38	death	death	NN	NN	_	40	compound	_	_
39	specification	specification	NN	NN	_	40	compound	_	_
40	protein	protein	NN	NN	_	35	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	neuron-specific	neuron-specific	JJ	JJ	_	46	amod	_	_
43	mediator	mediator	NN	NN	_	46	compound	_	_
44	of	of	IN	IN	_	46	amod	_	_
45	cell	cell	NN	NN	_	46	compound	_	_
46	death	death	NN	NN	_	35	dep	_	_
47	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	expression	expression	NN	NN	_	27	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Nfil3	nfil3	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	2	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	also	also	RB	RB	_	12	dep	_	_
12	called	call	VBN	VBN	_	9	dep	_	_
13	E4bp4	e4bp4	NN	NN	_	12	xcomp	_	_
14	)	)	-RRB-	-RRB-	_	12	punct	_	_
15	,	,	,	,	_	9	punct	_	_
16	but	but	CC	CC	_	9	cc	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Hlf	hlf	NN	NN	_	9	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	Dbp	dbp	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	or	or	CC	CC	_	19	cc	_	_
24	Tef	tef	NN	NN	_	19	conj	_	_
25	,	,	,	,	_	2	punct	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	found	find	VBN	VBN	_	0	root	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	regulated	regulate	VBN	VBN	_	27	xcomp	_	_
31	by	by	IN	IN	_	32	case	_	_
32	IL-3	il-3	NN	NN	_	30	nmod	_	_
33	in	in	IN	IN	_	37	case	_	_
34	mouse	mouse	NN	NN	_	37	compound	_	_
35	pro-B	pro-b	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	30	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	Baf-3	baf-3	NN	NN	_	37	dep	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	FL5.12	fl5.12	NN	NN	_	39	conj	_	_
42	)	)	-RRB-	-RRB-	_	39	punct	_	_
43	.	.	.	.	_	27	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	Nfil3/E4bp4	nfil3/e4bp4	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
9	as	as	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	``	``	``	``	_	14	punct	_	_
12	delayed-early	delayed-early	JJ	JJ	_	14	amod	_	_
13	IL-3-responsive	il-3-responsive	JJ	JJ	_	14	amod	_	_
14	gene	gene	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	requiring	require	VBG	VBG	_	8	advcl	_	_
17	de	de	FW	FW	_	20	amod	_	_
18	novo	novo	FW	FW	_	17	dep	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	14	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-3	il-3	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	enforced	enforced	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	14	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	NFIL3/E4BP4	nfil3/e4bp4	NN	NN	_	13	compound	_	_
13	cDNA	cdna	NN	NN	_	8	nmod	_	_
14	promoted	promote	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	survival	survival	NN	NN	_	14	dobj	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	growth	growth	NN	NN	_	16	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	IL-3-dependent	il-3-dependent	JJ	JJ	_	24	amod	_	_
23	pro-B	pro-b	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	NFIL3/E4BP4	nfil3/e4bp4	NN	NN	_	3	dobj	_	_
5	(	(	-LRB-	-LRB-	_	14	punct	_	_
6	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
7	factor	factor	NN	NN	_	14	compound	_	_
8	regulated	regulate	VBN	VBN	_	14	amod	_	_
9	by	by	IN	IN	_	14	amod	_	_
10	IL-3/adenovirus	il-3/adenovirus	NN	NN	_	14	compound	_	_
11	E4	e4	NN	NN	_	14	compound	_	_
12	promoter	promoter	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	4	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	in	in	IN	IN	_	22	case	_	_
17	a	a	DT	DT	_	22	det	_	_
18	distinct	distinct	JJ	JJ	_	22	amod	_	_
19	growth	growth	NN	NN	_	22	compound	_	_
20	factor-regulated	factor-regulated	JJ	JJ	_	22	amod	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	3	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	responsible	responsible	JJ	JJ	_	3	dep	_	_
26	for	for	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	survival	survival	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	early	early	JJ	JJ	_	32	amod	_	_
31	B-cell	b-cell	NN	NN	_	32	compound	_	_
32	progenitors	progenitor	NNS	NNS	_	28	nmod	_	_
33	,	,	,	,	_	25	punct	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	whose	whose	WP$	WP$	_	36	nmod:poss	_	_
36	alteration	alteration	NN	NN	_	39	nsubj	_	_
37	by	by	IN	IN	_	38	case	_	_
38	E2A-HLF	e2a-hlf	NN	NN	_	36	nmod	_	_
39	leads	lead	VBZ	VBZ	_	25	conj	_	_
40	to	to	TO	TO	_	44	case	_	_
41	childhood	childhood	NN	NN	_	44	compound	_	_
42	B	b	NN	NN	_	44	compound	_	_
43	lineage	lineage	NN	NN	_	44	compound	_	_
44	leukemia	leukemia	NN	NN	_	39	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	Neuronal	neuronal	JJ	JJ	_	8	amod	_	_
2	(	(	-LRB-	-LRB-	_	8	punct	_	_
3	type	type	NN	NN	_	8	compound	_	_
4	I	i	CD	CD	_	8	nummod	_	_
5	)	)	-RRB-	-RRB-	_	8	punct	_	_
6	nitric	nitric	JJ	JJ	_	8	amod	_	_
7	oxide	oxide	NN	NN	_	8	compound	_	_
8	synthase	synthase	NN	NN	_	9	nsubj	_	_
9	regulates	regulate	VBZ	VBZ	_	0	root	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	kappaB	kappab	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	immunologic	immunologic	JJ	JJ	_	22	amod	_	_
16	(	(	-LRB-	-LRB-	_	22	punct	_	_
17	type	type	NN	NN	_	22	compound	_	_
18	II	ii	CD	CD	_	22	nummod	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	nitric	nitric	JJ	JJ	_	22	amod	_	_
21	oxide	oxide	NN	NN	_	22	compound	_	_
22	synthase	synthase	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	13	conj	_	_
24	.	.	.	.	_	9	punct	_	_

1	Nitric	nitric	JJ	JJ	_	2	amod	_	_
2	oxide	oxide	NN	NN	_	3	nsubj	_	_
3	subserves	subserve	VBZ	VBZ	_	0	root	_	_
4	diverse	diverse	JJ	JJ	_	6	amod	_	_
5	physiologic	physiologic	JJ	JJ	_	4	dep	_	_
6	roles	role	NNS	NNS	_	3	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nervous	nervous	JJ	JJ	_	10	amod	_	_
10	system	system	NN	NN	_	3	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	NO	no	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	produced	produce	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	14	case	_	_
5	at	at	IN	IN	_	6	case	_	_
6	least	least	JJS	JJS	_	7	nmod:npmod	_	_
7	three	three	CD	CD	_	14	nummod	_	_
8	different	different	JJ	JJ	_	14	amod	_	_
9	NO	no	NN	NN	_	14	compound	_	_
10	synthase	synthase	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	NOS	nos	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	isoforms	isoform	NNS	NNS	_	3	nmod	_	_
15	:	:	:	:	_	3	punct	_	_
16	neuronal	neuronal	JJ	JJ	_	17	amod	_	_
17	NOS	nos	NN	NN	_	3	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	nNOS	nnos	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	17	punct	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	NOS	no	NNS	NNS	_	17	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	immunologic	immunologic	JJ	JJ	_	27	amod	_	_
27	NOS	nos	NN	NN	_	17	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	iNOS	inos	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	nNOS	nnos	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	the	the	DT	DT	_	8	det	_	_
7	predominant	predominant	JJ	JJ	_	8	amod	_	_
8	isoform	isoform	NN	NN	_	2	ccomp	_	_
9	constitutively	constitutively	RB	RB	_	10	advmod	_	_
10	expressed	express	VBN	VBN	_	8	acl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	glia	glia	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	NO	no	NN	NN	_	7	nsubj	_	_
2	derived	derive	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	4	case	_	_
4	nNOS	nnos	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	glia	glia	NN	NN	_	4	nmod	_	_
7	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	7	dobj	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	kappaB	kappab	NN	NN	_	10	dep	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	NF	nf	NN	NN	_	16	compound	_	_
16	kappaB	kappab	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	as	as	IN	IN	_	21	mark	_	_
19	NOS	nos	NN	NN	_	20	compound	_	_
20	inhibitors	inhibitor	NNS	NNS	_	21	nsubj	_	_
21	enhance	enhance	VBP	VBP	_	7	advcl	_	_
22	basal	basal	JJ	JJ	_	25	amod	_	_
23	NF	nf	NN	NN	_	24	compound	_	_
24	kappaB	kappab	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	7	punct	_	_

1	Pyrrolidine	pyrrolidine	NN	NN	_	2	compound	_	_
2	dithiocarbamate	dithiocarbamate	NN	NN	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PDTC	pdtc	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	an	a	DT	DT	_	8	det	_	_
8	inhibitor	inhibitor	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF	nf	NN	NN	_	11	compound	_	_
11	kappaB	kappab	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	most	most	JJS	JJS	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	;	;	:	:	_	8	punct	_	_
16	however	however	RB	RB	_	19	advmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	show	show	VBP	VBP	_	8	parataxis	_	_
20	that	that	IN	IN	_	26	mark	_	_
21	PDTC	pdtc	NN	NN	_	26	nsubj	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	also	also	RB	RB	_	26	advmod	_	_
24	a	a	DT	DT	_	26	det	_	_
25	potent	potent	JJ	JJ	_	26	amod	_	_
26	scavenger	scavenger	NN	NN	_	19	ccomp	_	_
27	of	of	IN	IN	_	28	case	_	_
28	NO	no	NN	NN	_	26	nmod	_	_
29	through	through	IN	IN	_	30	case	_	_
30	formation	formation	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	mononitrosyl	mononitrosyl	NN	NN	_	34	compound	_	_
33	iron	iron	NN	NN	_	34	compound	_	_
34	complexes	complex	NNS	NNS	_	30	nmod	_	_
35	with	with	IN	IN	_	36	case	_	_
36	PDTC	pdtc	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	18	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	10	det	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	T-cell	t-cell	NN	NN	_	10	compound	_	_
8	lymphoma	lymphoma	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	3	appos	_	_
11	,	,	,	,	_	18	punct	_	_
12	tumor	tumor	NN	NN	_	14	compound	_	_
13	necrosis	necrosis	NN	NN	_	14	compound	_	_
14	factor-alpha	factor-alpha	NN	NN	_	18	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	induces	induce	VBZ	VBZ	_	0	root	_	_
19	NF	nf	NN	NN	_	20	compound	_	_
20	kappaB	kappab	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	18	dobj	_	_
22	that	that	WDT	WDT	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	inhibited	inhibit	VBN	VBN	_	21	acl:relcl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	PDTC	pdtc	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	Contrary	contrary	JJ	JJ	_	12	advmod	_	_
2	to	to	TO	TO	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Jurkat	jurkat	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	PDTC	pdtc	NN	NN	_	12	nsubj	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	inhibit	inhibit	VB	VB	_	0	root	_	_
13	tumor	tumor	NN	NN	_	18	compound	_	_
14	necrosis	necrosis	NN	NN	_	18	compound	_	_
15	factor-alpha-induced	factor-alpha-induced	JJ	JJ	_	18	amod	_	_
16	NF	nf	NN	NN	_	17	compound	_	_
17	kappaB	kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	12	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	astrocytes	astrocyte	NNS	NNS	_	12	nmod	_	_
21	;	;	:	:	_	12	punct	_	_
22	instead	instead	RB	RB	_	25	advmod	_	_
23	PDTC	pdtc	NN	NN	_	25	nsubj	_	_
24	itself	itself	PRP	PRP	_	23	nmod:npmod	_	_
25	induces	induce	VBZ	VBZ	_	12	parataxis	_	_
26	NF	nf	JJ	JJ	_	27	amod	_	_
27	kappaB	kappab	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	astrocytes	astrocyte	NNS	NNS	_	25	nmod	_	_
31	,	,	,	,	_	25	punct	_	_
32	and	and	CC	CC	_	25	cc	_	_
33	this	this	DT	DT	_	36	nsubj	_	_
34	may	may	MD	MD	_	36	aux	_	_
35	be	be	VB	VB	_	36	cop	_	_
36	related	related	JJ	JJ	_	25	conj	_	_
37	to	to	TO	TO	_	38	case	_	_
38	scavenging	scavenging	NN	NN	_	36	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	endogenously	endogenously	RB	RB	_	41	advmod	_	_
41	produced	produce	VBD	VBD	_	42	amod	_	_
42	NO	no	NN	NN	_	38	nmod	_	_
43	by	by	IN	IN	_	47	case	_	_
44	the	the	DT	DT	_	47	det	_	_
45	PDTC	pdtc	NN	NN	_	47	compound	_	_
46	iron	iron	NN	NN	_	47	compound	_	_
47	complex	complex	NN	NN	_	38	nmod	_	_
48	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	astrocytes	astrocyte	NNS	NNS	_	6	nmod	_	_
3	PDTC	pdtc	NN	NN	_	6	nsubj	_	_
4	also	also	RB	RB	_	6	advmod	_	_
5	dramatically	dramatically	RB	RB	_	6	advmod	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	11	det	_	_
8	NF	nf	NN	NN	_	11	compound	_	_
9	kappaB-	kappab-	NN	NN	_	11	compound	_	_
10	dependent	dependent	JJ	JJ	_	11	amod	_	_
11	enzyme	enzyme	NN	NN	_	6	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	iNOS	inos	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	6	punct	_	_
15	supporting	support	VBG	VBG	_	6	advcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	physiologic	physiologic	JJ	JJ	_	18	amod	_	_
18	relevance	relevance	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	endogenous	endogenous	JJ	JJ	_	22	amod	_	_
21	NO	no	NN	NN	_	22	compound	_	_
22	regulation	regulation	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	NF	nf	NN	NN	_	25	compound	_	_
25	kappaB	kappab	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	NF	nf	NN	NN	_	2	compound	_	_
2	kappaB	kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	glia	glia	NN	NN	_	3	nmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	mice	mouse	NNS	NNS	_	5	nmod	_	_
8	lacking	lack	VBG	VBG	_	7	acl	_	_
9	nNOS	nnos	NN	NN	_	8	dobj	_	_
10	responds	respond	VBZ	VBZ	_	0	root	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	rapidly	rapidly	RB	RB	_	10	advmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	PDTC	pdtc	NN	NN	_	12	nmod	_	_
15	compared	compare	VBN	VBN	_	17	case	_	_
16	with	with	IN	IN	_	17	case	_	_
17	astrocytes	astrocyte	NNS	NNS	_	10	advcl	_	_
18	from	from	IN	IN	_	20	case	_	_
19	wild-type	wild-type	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	nNOS	nnos	NN	NN	_	8	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	astrocytes	astrocyte	NNS	NNS	_	5	nmod	_	_
8	regulates	regulate	VBZ	VBZ	_	3	ccomp	_	_
9	NF	nf	NN	NN	_	10	compound	_	_
10	kappaB	kappab	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	iNOS	inos	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	indicate	indicate	VBP	VBP	_	3	conj	_	_
18	a	a	DT	DT	_	21	det	_	_
19	novel	novel	JJ	JJ	_	21	amod	_	_
20	regulatory	regulatory	JJ	JJ	_	19	dep	_	_
21	role	role	NN	NN	_	17	dobj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	nNOS	nnos	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	29	case	_	_
25	tonically	tonically	RB	RB	_	26	advmod	_	_
26	suppressing	suppress	VBG	VBG	_	29	amod	_	_
27	central	central	JJ	JJ	_	28	amod	_	_
28	nervous	nervous	JJ	JJ	_	26	dep	_	_
29	system	system	NN	NN	_	21	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	NF	nf	NN	NN	_	33	compound	_	_
32	kappaB-regulated	kappab-regulated	JJ	JJ	_	33	amod	_	_
33	genes	gene	NNS	NNS	_	29	appos	_	_
34	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Ras	ras	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	mitogen-activated	mitogen-activated	JJ	JJ	_	7	amod	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	3	conj	_	_
9	by	by	IN	IN	_	12	case	_	_
10	terminal	terminal	JJ	JJ	_	12	amod	_	_
11	complement	complement	NN	NN	_	12	compound	_	_
12	complexes	complex	NNS	NNS	_	1	nmod	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	G	g	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	0	root	_	_
16	dependent	dependent	JJ	JJ	_	15	amod	_	_
17	.	.	.	.	_	15	punct	_	_

1	Assembly	assembly	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	terminal	terminal	JJ	JJ	_	5	amod	_	_
4	complement	complement	NN	NN	_	5	compound	_	_
5	complexes	complex	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TCC	tcc	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	C5b-7	c5b-7	NN	NN	_	1	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	C5b-8	c5b-8	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	C5b-9	c5b-9	NN	NN	_	9	conj	_	_
15	on	on	IN	IN	_	17	case	_	_
16	target	target	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	1	nmod	_	_
18	during	during	IN	IN	_	22	case	_	_
19	acute	acute	JJ	JJ	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	chronic	chronic	JJ	JJ	_	19	conj	_	_
22	inflammation	inflammation	NN	NN	_	1	nmod	_	_
23	induces	induce	VBZ	VBZ	_	0	root	_	_
24	hydrolysis	hydrolysis	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	plasma	plasma	NN	NN	_	28	compound	_	_
27	membrane	membrane	NN	NN	_	28	compound	_	_
28	phospholipids	phospholipid	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	heterotrimeric	heterotrimeric	JJ	JJ	_	33	amod	_	_
31	G	g	NN	NN	_	32	compound	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	24	conj	_	_
34	.	.	.	.	_	23	punct	_	_

1	TCC	tcc	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	stimulate	stimulate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	variety	variety	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	activities	activity	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	include	include	VBP	VBP	_	8	acl:relcl	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	synthesis	synthesis	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	proto-oncogene	proto-oncogene	JJ	JJ	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	mitotic	mitotic	JJ	JJ	_	20	amod	_	_
20	signaling	signaling	NN	NN	_	13	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Now	now	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	sublytic	sublytic	JJ	JJ	_	6	amod	_	_
6	TCC	tcc	NN	NN	_	7	nsubj	_	_
7	induced	induce	VBD	VBD	_	3	ccomp	_	_
8	Ras	ras	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	Raf-1	raf-1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	extracellular	extracellular	JJ	JJ	_	17	amod	_	_
14	signal-regulated	signal-regulated	JJ	JJ	_	17	amod	_	_
15	kinase	kinase	NN	NN	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	ERK	erk	NN	NN	_	8	conj	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	1	1	CD	CD	_	17	nummod	_	_
20	activation	activation	NN	NN	_	8	dep	_	_
21	in	in	IN	IN	_	25	case	_	_
22	JY25	jy25	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	7	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	exposed	expose	VBN	VBN	_	14	advcl	_	_
5	to	to	TO	TO	_	6	case	_	_
6	C5b-9	c5b-9	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	GTP-bound	gtp-bound	JJ	JJ	_	9	amod	_	_
9	Ras	ras	NN	NN	_	14	nsubjpass	_	_
10	in	in	IN	IN	_	12	case	_	_
11	anti-C5b-9	anti-c5b-9	JJ	JJ	_	12	amod	_	_
12	immunoprecipitates	immunoprecipitate	NNS	NNS	_	9	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	increased	increase	VBN	VBN	_	0	root	_	_
15	3.2-fold	3.2-fold	RB	RB	_	14	dobj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	2	2	CD	CD	_	18	nummod	_	_
18	min	min	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	while	while	IN	IN	_	27	mark	_	_
21	GTP-bound	gtp-bound	JJ	JJ	_	22	amod	_	_
22	Ras	ras	NN	NN	_	27	nsubjpass	_	_
23	in	in	IN	IN	_	25	case	_	_
24	anti-Ras	anti-ras	JJ	JJ	_	25	amod	_	_
25	immunoprecipitates	immunoprecipitate	NNS	NNS	_	22	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	increased	increase	VBN	VBN	_	14	advcl	_	_
28	2-fold	2-fold	RB	RB	_	27	dobj	_	_
29	at	at	IN	IN	_	31	case	_	_
30	10	10	CD	CD	_	31	nummod	_	_
31	min	min	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	C5b-9	c5b-9	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	C5b-7	c5b-7	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	2	cc	_	_
8	C5b6	c5b6	NN	NN	_	2	conj	_	_
9	,	,	,	,	_	2	punct	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	Raf-1	raf-1	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	iobj	_	_
14	maximum	maximum	NN	NN	_	10	dobj	_	_
15	3.3-fold	3.3-fold	RB	RB	_	14	advmod	_	_
16	at	at	IN	IN	_	18	case	_	_
17	2	2	CD	CD	_	18	nummod	_	_
18	min	min	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	2.8-fold	2.8-fold	RB	RB	_	14	conj	_	_
21	at	at	IN	IN	_	23	case	_	_
22	5	5	CD	CD	_	23	nummod	_	_
23	min	min	NN	NN	_	14	nmod	_	_
24	,	,	,	,	_	10	punct	_	_
25	respectively	respectively	RB	RB	_	10	advmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	ERK1	erk1	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	2-fold	2-fold	RB	RB	_	5	dep	_	_
5	increased	increase	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	C5b-9	c5b-9	NN	NN	_	5	nmod	_	_
8	at	at	IN	IN	_	10	case	_	_
9	2	2	CD	CD	_	10	nummod	_	_
10	min	min	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	by	by	IN	IN	_	13	case	_	_
13	C5b-7	c5b-7	NN	NN	_	7	conj	_	_
14	at	at	IN	IN	_	16	case	_	_
15	10	10	CD	CD	_	16	nummod	_	_
16	min	min	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	over	over	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	C5b6	c5b6	NN	NN	_	21	compound	_	_
21	level	level	NN	NN	_	5	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	mitogen-activated	mitogen-activated	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	MAPK	mapk	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	pathway	pathway	NN	NN	_	2	nmod	_	_
11	on	on	IN	IN	_	14	case	_	_
12	TCC-inducible	tcc-inducible	JJ	JJ	_	14	amod	_	_
13	mitotic	mitotic	JJ	JJ	_	14	amod	_	_
14	signaling	signaling	NN	NN	_	2	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	evaluated	evaluate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	assessing	assess	VBG	VBG	_	16	advcl	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	29	compound	_	_
21	and	and	CC	CC	_	29	cc	_	_
22	activator	activator	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	29	compound	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	AP-1	ap-1	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	DNA-binding	dna-binding	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	18	dobj	_	_
30	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	MAPK/ERK-specific	mapk/erk-specific	JJ	JJ	_	3	amod	_	_
3	inhibitor	inhibitor	NN	NN	_	6	nsubj	_	_
4	PD	pd	NN	NN	_	3	dep	_	_
5	098,059	098,059	CD	CD	_	4	nummod	_	_
6	abolished	abolish	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	C5b-9-induced	c5b-9-induced	JJ	JJ	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	synthesis	synthesis	NN	NN	_	6	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	Involvement	involvement	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	G	g	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	MAPK	mapk	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	TCC	tcc	NN	NN	_	7	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	indicated	indicate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	inhibition	inhibition	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Raf-1	raf-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	ERK1	erk1	NN	NN	_	18	conj	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	18	dep	_	_
23	,	,	,	,	_	16	punct	_	_
24	as	as	RB	RB	_	16	cc	_	_
25	well	well	RB	RB	_	24	mwe	_	_
26	as	as	IN	IN	_	24	mwe	_	_
27	the	the	DT	DT	_	29	det	_	_
28	DNA	dna	NN	NN	_	29	compound	_	_
29	synthesis	synthesis	NN	NN	_	16	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	pretreatment	pretreatment	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	cells	cell	NNS	NNS	_	31	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	pertussis	pertussis	NN	NN	_	36	compound	_	_
36	toxin	toxin	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	Overexpression	overexpression	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	beta-adrenergic	beta-adrenergic	JJ	JJ	_	8	amod	_	_
4	receptor	receptor	NN	NN	_	8	compound	_	_
5	kinase	kinase	NN	NN	_	8	compound	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	8	amod	_	_
8	peptide	peptide	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	JY25	jy25	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	1	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	inhibited	inhibit	VBD	VBD	_	0	root	_	_
14	Raf-1	raf-1	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	ERK1	erk1	NN	NN	_	14	conj	_	_
17	activity	activity	NN	NN	_	14	dep	_	_
18	,	,	,	,	_	13	punct	_	_
19	indicating	indicate	VBG	VBG	_	13	advcl	_	_
20	a	a	DT	DT	_	22	det	_	_
21	direct	direct	JJ	JJ	_	22	amod	_	_
22	involvement	involvement	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	G	g	NN	NN	_	26	compound	_	_
25	betagamma	betagamma	NN	NN	_	26	compound	_	_
26	subunits	subunit	NNS	NNS	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	signal	signal	NN	NN	_	30	compound	_	_
30	transduction	transduction	NN	NN	_	22	nmod	_	_
31	generated	generate	VBN	VBN	_	30	acl	_	_
32	through	through	IN	IN	_	33	case	_	_
33	activation	activation	NN	NN	_	31	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	MAPK	mapk	NN	NN	_	36	compound	_	_
36	pathway	pathway	NN	NN	_	33	nmod	_	_
37	by	by	IN	IN	_	39	case	_	_
38	TCC	tcc	NN	NN	_	39	compound	_	_
39	assembly	assembly	NN	NN	_	33	nmod	_	_
40	in	in	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	plasma	plasma	NN	NN	_	43	compound	_	_
43	membrane	membrane	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	13	punct	_	_

1	Reconstitution	reconstitution	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	9	case	_	_
3	T	t	NN	NN	_	9	compound	_	_
4	cell	cell	NN	NN	_	9	compound	_	_
5	antigen	antigen	NN	NN	_	9	compound	_	_
6	receptor-induced	receptor-induced	JJ	JJ	_	9	amod	_	_
7	Erk2	erk2	NN	NN	_	8	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Lck-negative	lck-negative	JJ	JJ	_	13	amod	_	_
12	JCaM1	jcam1	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	Syk	syk	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	two	two	CD	CD	_	5	nummod	_	_
3	related	related	JJ	JJ	_	5	amod	_	_
4	protein-tyrosine	protein-tyrosine	JJ	JJ	_	5	amod	_	_
5	kinases	kinase	NNS	NNS	_	11	nsubjpass	_	_
6	Syk	syk	NN	NN	_	5	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Zap	zap	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	rapidly	rapidly	RB	RB	_	11	advmod	_	_
11	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
12	on	on	IN	IN	_	14	case	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	residues	residue	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	enzymatically	enzymatically	RB	RB	_	17	advmod	_	_
17	activated	activate	VBN	VBN	_	11	conj	_	_
18	upon	upon	IN	IN	_	19	case	_	_
19	crosslinking	crosslinking	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	T	t	NN	NN	_	25	compound	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	antigen	antigen	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activation	activation	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Syk	syk	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	less	less	RBR	RBR	_	12	advmod	_	_
12	dependent	dependent	JJ	JJ	_	4	ccomp	_	_
13	on	on	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	Src	src	NN	NN	_	17	compound	_	_
16	family	family	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	12	nmod	_	_
18	Lck	lck	NN	NN	_	17	dep	_	_
19	than	than	IN	IN	_	21	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	12	ccomp	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Zap	zap	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	overexpression	overexpression	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Syk	syk	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	Lck-negative	lck-negative	JJ	JJ	_	12	amod	_	_
11	JCaM1	jcam1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	enabled	enable	VBD	VBD	_	3	ccomp	_	_
14	the	the	DT	DT	_	19	det	_	_
15	T	t	NN	NN	_	19	compound	_	_
16	cell	cell	NN	NN	_	19	compound	_	_
17	antigen	antigen	NN	NN	_	19	compound	_	_
18	receptor/CD3	receptor/cd3	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	13	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	induce	induce	VB	VB	_	13	xcomp	_	_
22	a	a	DT	DT	_	24	det	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	33	case	_	_
26	the	the	DT	DT	_	33	det	_	_
27	mitogen-activated	mitogen-activated	JJ	JJ	_	29	amod	_	_
28	protein	protein	NN	NN	_	29	compound	_	_
29	kinase	kinase	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	MAPK	mapk	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	pathway	pathway	NN	NN	_	24	nmod	_	_
34	and	and	CC	CC	_	24	cc	_	_
35	expression	expression	NN	NN	_	24	conj	_	_
36	of	of	IN	IN	_	45	case	_	_
37	a	a	DT	DT	_	45	det	_	_
38	nuclear	nuclear	JJ	JJ	_	43	amod	_	_
39	factor	factor	NN	NN	_	43	compound	_	_
40	of	of	IN	IN	_	43	amod	_	_
41	activated	activate	VBN	VBN	_	43	amod	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	45	compound	_	_
44	reporter	reporter	NN	NN	_	45	compound	_	_
45	construct	construct	NN	NN	_	35	nmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	Zap	zap	NN	NN	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	protein-tyrosine	protein-tyrosine	JJ	JJ	_	8	amod	_	_
8	kinases	kinase	NNS	NNS	_	4	conj	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	unable	unable	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	reconstitute	reconstitute	VB	VB	_	10	xcomp	_	_
13	these	these	DT	DT	_	15	det	_	_
14	signaling	signaling	NN	NN	_	15	compound	_	_
15	pathways	pathway	NNS	NNS	_	12	dobj	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	expressed	express	VBN	VBN	_	10	advcl	_	_
18	at	at	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	same	same	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	Syk	syk	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
7	on	on	IN	IN	_	8	case	_	_
8	tyrosine	tyrosine	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	while	while	IN	IN	_	12	mark	_	_
11	Zap	zap	NN	NN	_	12	nsubj	_	_
12	was	be	VBD	VBD	_	6	advcl	_	_
13	not	not	RB	RB	_	12	neg	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	Syk-mediated	syk-mediated	JJ	JJ	_	8	amod	_	_
3	T	t	NN	NN	_	8	compound	_	_
4	cell	cell	NN	NN	_	8	compound	_	_
5	antigen	antigen	NN	NN	_	8	compound	_	_
6	receptor-induced	receptor-induced	JJ	JJ	_	8	amod	_	_
7	MAPK	mapk	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	10	nsubj	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	detectable	detectable	JJ	JJ	_	0	root	_	_
11	within	within	IN	IN	_	13	case	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	min	min	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	stimulation	stimulation	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	peaked	peak	VBD	VBD	_	10	conj	_	_
19	at	at	IN	IN	_	21	case	_	_
20	3-5	3-5	CD	CD	_	21	nummod	_	_
21	min	min	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	capacity	capacity	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Syk	syk	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	reconstitute	reconstitute	VB	VB	_	2	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	MAPK	mapk	NN	NN	_	9	compound	_	_
9	response	response	NN	NN	_	6	dobj	_	_
10	required	require	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	catalytic	catalytic	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Syk	syk	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	an	a	DT	DT	_	20	det	_	_
18	intact	intact	JJ	JJ	_	20	amod	_	_
19	autophosphorylation	autophosphorylation	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	13	appos	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	Y518	y518	NN	NN	_	20	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Y519	y519	NN	NN	_	22	conj	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	,	,	,	,	_	13	punct	_	_
27	both	both	DT	DT	_	31	dep	_	_
28	Src	src	NN	NN	_	31	compound	_	_
29	homology	homology	NN	NN	_	31	compound	_	_
30	2	2	CD	CD	_	31	nummod	_	_
31	domains	domain	NNS	NNS	_	13	appos	_	_
32	and	and	CC	CC	_	10	cc	_	_
33	it	it	PRP	PRP	_	35	nsubjpass	_	_
34	was	be	VBD	VBD	_	35	auxpass	_	_
35	blocked	block	VBN	VBN	_	10	conj	_	_
36	by	by	IN	IN	_	42	case	_	_
37	the	the	DT	DT	_	42	det	_	_
38	inhibitory	inhibitory	JJ	JJ	_	42	amod	_	_
39	N17-mutated	n17-mutated	JJ	JJ	_	42	amod	_	_
40	dominant-negative	dominant-negative	JJ	JJ	_	42	amod	_	_
41	Ras	ras	NN	NN	_	42	compound	_	_
42	construct	construct	NN	NN	_	35	nmod	_	_
43	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	Y341	y341	NN	NN	_	23	nsubj	_	_
3	--&gt;	--&gt;	TO	TO	_	2	dep	_	_
4	F	f	NN	NN	_	5	compound	_	_
5	mutant	mutant	NN	NN	_	2	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Syk	syk	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	deficient	deficient	JJ	JJ	_	2	acl:relcl	_	_
12	in	in	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	interaction	interaction	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	phospholipase	phospholipase	NN	NN	_	17	compound	_	_
17	Cy1	cy1	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Vav	vav	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	2	punct	_	_
21	was	be	VBD	VBD	_	23	cop	_	_
22	less	less	RBR	RBR	_	23	advmod	_	_
23	efficient	efficient	JJ	JJ	_	0	root	_	_
24	than	than	IN	IN	_	26	case	_	_
25	wild-type	wild-type	JJ	JJ	_	26	amod	_	_
26	Syk	syk	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	23	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	Syk	syk	NN	NN	_	13	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	contrast	contrast	NN	NN	_	13	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	Zap	zap	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	transduce	transduce	VB	VB	_	3	ccomp	_	_
14	signals	signal	NNS	NNS	_	13	dobj	_	_
15	from	from	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	T	t	NN	NN	_	20	compound	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	antigen	antigen	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	14	nmod	_	_
21	independently	independently	RB	RB	_	13	advmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Lck	lck	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Use	use	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	arsenic	arsenic	JJ	JJ	_	4	amod	_	_
4	trioxide	trioxide	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	As2O3	as2o3	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	treatment	treatment	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	acute	acute	JJ	JJ	_	16	amod	_	_
13	promyelocytic	promyelocytic	JJ	JJ	_	16	amod	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	APL	apl	NN	NN	_	10	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	:	:	:	:	_	16	punct	_	_
19	II	ii	CD	CD	_	16	nummod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	efficacy	efficacy	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	pharmacokinetics	pharmacokinetic	NNS	NNS	_	2	conj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	relapsed	relapsed	JJ	JJ	_	7	amod	_	_
7	patients	patient	NNS	NNS	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	therapeutic	therapeutic	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	21	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	arsenic	arsenic	JJ	JJ	_	6	amod	_	_
6	trioxide	trioxide	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	As2O3	as2o3	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	treatment	treatment	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	promyelocytic	promyelocytic	JJ	JJ	_	16	amod	_	_
16	leukemia	leukemia	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	APL	apl	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	evaluated	evaluate	VBN	VBN	_	0	root	_	_
22	among	among	IN	IN	_	25	case	_	_
23	15	15	CD	CD	_	25	nummod	_	_
24	APL	apl	NN	NN	_	25	compound	_	_
25	patients	patient	NNS	NNS	_	21	nmod	_	_
26	at	at	IN	IN	_	27	case	_	_
27	relapse	relapse	NN	NN	_	25	nmod	_	_
28	after	after	IN	IN	_	40	case	_	_
29	all-trans	all-trans	JJ	JJ	_	31	amod	_	_
30	retinoic	retinoic	JJ	JJ	_	31	amod	_	_
31	acid	acid	NN	NN	_	35	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ATRA	atra	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	induced	induce	VBD	VBD	_	40	amod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	chemotherapy	chemotherapy	NN	NN	_	35	conj	_	_
38	maintained	maintain	VBD	VBD	_	37	dep	_	_
39	complete	complete	JJ	JJ	_	40	amod	_	_
40	remission	remission	NN	NN	_	25	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	CR	cr	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	21	punct	_	_

1	As2O3	as2o3	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	administered	administer	VBN	VBN	_	0	root	_	_
4	intravenously	intravenously	RB	RB	_	3	advmod	_	_
5	at	at	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	dose	dose	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	mg/d	mg/d	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	CR	cr	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	achieved	achieve	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	nine	nine	CD	CD	_	4	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	10	10	CD	CD	_	13	nummod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	90	90	CD	CD	_	11	nummod	_	_
11	%	%	NN	NN	_	13	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	patients	patient	NNS	NNS	_	6	nmod	_	_
14	treated	treat	VBN	VBN	_	6	acl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	As2O3	as2o3	NN	NN	_	14	nmod	_	_
17	alone	alone	RB	RB	_	14	advmod	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	remaining	remain	VBG	VBG	_	23	amod	_	_
22	five	five	CD	CD	_	23	nummod	_	_
23	patients	patient	NNS	NNS	_	6	conj	_	_
24	treated	treat	VBN	VBN	_	23	acl	_	_
25	by	by	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	combination	combination	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	As2O3	as2o3	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	low-dose	low-dose	JJ	JJ	_	33	amod	_	_
32	chemotherapeutic	chemotherapeutic	JJ	JJ	_	33	amod	_	_
33	drugs	drug	NNS	NNS	_	29	conj	_	_
34	or	or	CC	CC	_	33	cc	_	_
35	ATRA	atra	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	4	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	treatment	treatment	NN	NN	_	8	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	As2O3	as2o3	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	was	be	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	12	neg	_	_
10	bone	bone	NN	NN	_	12	compound	_	_
11	marrow	marrow	NN	NN	_	12	compound	_	_
12	depression	depression	NN	NN	_	8	nsubj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	only	only	RB	RB	_	15	advmod	_	_
15	limited	limited	JJ	JJ	_	17	amod	_	_
16	side	side	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	19	nsubjpass	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	encountered	encounter	VBN	VBN	_	8	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	Pharmacokinetic	pharmacokinetic	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	11	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	performed	perform	VBN	VBN	_	2	acl:relcl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	eight	eight	CD	CD	_	9	nummod	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	11	punct	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	28	mark	_	_
13	after	after	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	peak	peak	JJ	JJ	_	16	amod	_	_
16	level	level	NN	NN	_	28	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	5.54	5.54	CD	CD	_	19	nummod	_	_
19	micromol/L	micromol/l	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	19	dep	_	_
21	7.30	7.30	CD	CD	_	22	nummod	_	_
22	micromol/L	micromol/l	NN	NN	_	19	dep	_	_
23	,	,	,	,	_	28	punct	_	_
24	plasma	plasma	NN	NN	_	25	compound	_	_
25	arsenic	arsenic	NN	NN	_	28	nsubjpass	_	_
26	was	be	VBD	VBD	_	28	auxpass	_	_
27	rapidly	rapidly	RB	RB	_	28	advmod	_	_
28	eliminated	eliminate	VBN	VBN	_	11	ccomp	_	_
29	,	,	,	,	_	28	punct	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	the	the	DT	DT	_	33	det	_	_
32	continuous	continuous	JJ	JJ	_	33	amod	_	_
33	administration	administration	NN	NN	_	38	nsubj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	As2O3	as2o3	NN	NN	_	33	nmod	_	_
36	did	do	VBD	VBD	_	38	aux	_	_
37	not	not	RB	RB	_	38	neg	_	_
38	alter	alter	VB	VB	_	28	conj	_	_
39	its	its	PRP$	PRP$	_	41	nmod:poss	_	_
40	pharmacokinetic	pharmacokinetic	JJ	JJ	_	41	amod	_	_
41	behaviors	behavior	NNS	NNS	_	38	dobj	_	_
42	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	amounts	amount	NNS	NNS	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	arsenic	arsenic	NN	NN	_	5	nmod	_	_
8	appeared	appear	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	urine	urine	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	daily	daily	JJ	JJ	_	16	amod	_	_
16	excretion	excretion	NN	NN	_	8	nmod	_	_
17	accounting	account	VBG	VBG	_	16	acl	_	_
18	for	for	IN	IN	_	21	case	_	_
19	approximately	approximately	RB	RB	_	21	advmod	_	_
20	1	1	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	17	nmod	_	_
22	to	to	TO	TO	_	21	dep	_	_
23	8	8	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	21	dep	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	total	total	JJ	JJ	_	29	amod	_	_
28	daily	daily	RB	RB	_	29	advmod	_	_
29	dose	dose	NN	NN	_	21	nmod	_	_
30	administered	administer	VBN	VBN	_	29	acl	_	_
31	.	.	.	.	_	8	punct	_	_

1	Arsenic	arsenic	JJ	JJ	_	2	amod	_	_
2	contents	contents	NNS	NNS	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	hair	hair	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	nail	nail	NN	NN	_	4	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	peak	peak	JJ	JJ	_	13	amod	_	_
13	content	content	NN	NN	_	17	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	arsenic	arsenic	JJ	JJ	_	13	nmod	_	_
16	could	could	MD	MD	_	17	aux	_	_
17	reach	reach	VB	VB	_	8	conj	_	_
18	2.5	2.5	CD	CD	_	17	dobj	_	_
19	to	to	TO	TO	_	18	dep	_	_
20	2.7	2.7	CD	CD	_	18	dep	_	_
21	microg/g	microg/g	NN	NN	_	22	compound	_	_
22	tissue	tissue	NN	NN	_	18	dep	_	_
23	at	at	IN	IN	_	24	case	_	_
24	CR	cr	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	decline	decline	NN	NN	_	17	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	arsenic	arsenic	JJ	JJ	_	11	amod	_	_
11	content	content	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	hair	hair	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	nail	nail	NN	NN	_	13	conj	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	observed	observe	VBN	VBN	_	0	root	_	_
18	after	after	IN	IN	_	19	case	_	_
19	withdrawal	withdrawal	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	drug	drug	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	As2O3	as2o3	NN	NN	_	5	compound	_	_
5	treatment	treatment	NN	NN	_	12	nsubj	_	_
6	is	be	VBZ	VBZ	_	12	cop	_	_
7	an	a	DT	DT	_	12	det	_	_
8	effective	effective	JJ	JJ	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	relatively	relatively	RB	RB	_	11	advmod	_	_
11	safe	safe	JJ	JJ	_	8	conj	_	_
12	drug	drug	NN	NN	_	2	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	APL	apl	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	refractory	refractory	JJ	JJ	_	15	amod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	ATRA	atra	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	conventional	conventional	JJ	JJ	_	21	amod	_	_
21	chemotherapy	chemotherapy	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Preferential	preferential	JJ	JJ	_	2	amod	_	_
2	presentation	presentation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	herpes	herpes	NN	NN	_	8	compound	_	_
5	simplex	simplex	NN	NN	_	8	compound	_	_
6	virus	virus	NN	NN	_	8	compound	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	antigen	antigen	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	HLA	hla	NN	NN	_	11	compound	_	_
11	DQA1*0501/DQB1*0201	dqa1*0501/dqb1*0201	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	comparison	comparison	NN	NN	_	2	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	HLA	hla	NN	NN	_	16	compound	_	_
16	DQA1*0201/DQB1*0201	dqa1*0201/dqb1*0201	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	HLA	hla	NN	NN	_	4	compound	_	_
3	DQA1	dqa1	NN	NN	_	4	compound	_	_
4	locus	locus	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	polymorphic	polymorphic	JJ	JJ	_	0	root	_	_
7	.	.	.	.	_	6	punct	_	_

1	Haplotypes	haplotype	NNS	NNS	_	16	nsubjpass	_	_
2	containing	contain	VBG	VBG	_	1	acl	_	_
3	HLA	hla	NN	NN	_	4	compound	_	_
4	DQA1*0501	dqa1*0501	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	HLA	hla	NN	NN	_	9	compound	_	_
9	DQA1*0201	dqa1*0201	NN	NN	_	4	conj	_	_
10	,	,	,	,	_	1	punct	_	_
11	together	together	RB	RB	_	14	advmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	HLA	hla	NN	NN	_	14	compound	_	_
14	DQB1*0201	dqb1*0201	NN	NN	_	16	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	20	case	_	_
18	Grave	grave	NN	NN	_	20	nmod:poss	_	_
19	's	's	POS	POS	_	20	case	_	_
20	disease	disease	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	celiac	celiac	JJ	JJ	_	23	amod	_	_
23	sprue	sprue	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	correlate	correlate	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	DQA1	dqa1	NN	NN	_	12	compound	_	_
12	polymorphism	polymorphism	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	18	nsubj	_	_
3	infiltrating	infiltrate	VBG	VBG	_	2	acl	_	_
4	a	a	DT	DT	_	7	det	_	_
5	herpes	herpes	NN	NN	_	7	compound	_	_
6	simplex	simplex	NN	NN	_	7	compound	_	_
7	virus	virus	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HSV	hsv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	lesion	lesion	NN	NN	_	3	dobj	_	_
12	from	from	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	HLA	hla	NN	NN	_	17	compound	_	_
15	DQ	dq	NN	NN	_	17	compound	_	_
16	2,7	2,7	CD	CD	_	17	nummod	_	_
17	individual	individual	NN	NN	_	11	nmod	_	_
18	yielded	yield	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	22	det	_	_
20	virus-specific	virus-specific	JJ	JJ	_	22	amod	_	_
21	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
22	clone	clone	NN	NN	_	18	dobj	_	_
23	restricted	restrict	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	DQ2	dq2	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	Presentation	presentation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	viral	viral	JJ	JJ	_	4	amod	_	_
4	peptide	peptide	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	protein	protein	NN	NN	_	4	conj	_	_
7	segregated	segregate	VBD	VBD	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	DQA1	dqa1	NN	NN	_	10	compound	_	_
10	allele	allele	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	because	because	IN	IN	_	18	mark	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	18	nsubj	_	_
15	bearing	bear	VBG	VBG	_	14	acl	_	_
16	DQA1*0501/DQB1*0201	dqa1*0501/dqb1*0201	NN	NN	_	17	compound	_	_
17	heterodimers	heterodimer	NNS	NNS	_	15	dobj	_	_
18	presented	present	VBD	VBD	_	7	advcl	_	_
19	antigen	antigen	NN	NN	_	18	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	proliferation	proliferation	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	cytotoxicity	cytotoxicity	NN	NN	_	21	conj	_	_
24	assays	assay	NNS	NNS	_	21	dep	_	_
25	much	much	RB	RB	_	27	advmod	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	efficiently	efficiently	RB	RB	_	18	advmod	_	_
28	than	than	IN	IN	_	30	mark	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	27	advcl	_	_
31	bearing	bear	VBG	VBG	_	30	acl	_	_
32	DQA1*0201/DQB1*0201	dqa1*0201/dqb1*0201	NN	NN	_	31	dobj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Binding	binding	NN	NN	_	19	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	viral	viral	JJ	JJ	_	4	amod	_	_
4	peptide	peptide	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	1	nmod	_	_
8	bearing	bear	VBG	VBG	_	7	acl	_	_
9	DQA1*0201	dqa1*0201	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	1	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	comparison	comparison	NN	NN	_	19	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	DQA1*0501	dqa1*0501	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	was	be	VBD	VBD	_	19	auxpass	_	_
17	only	only	RB	RB	_	18	advmod	_	_
18	moderately	moderately	RB	RB	_	19	advmod	_	_
19	reduced	reduce	VBN	VBN	_	0	root	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	may	may	MD	MD	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	explain	explain	VB	VB	_	19	conj	_	_
24	this	this	DT	DT	_	25	det	_	_
25	effect	effect	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	19	punct	_	_

1	Truncation	truncation	NN	NN	_	12	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	substitution	substitution	NN	NN	_	1	conj	_	_
4	analyses	analysis	NNS	NNS	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	peptide	peptide	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	performed	perform	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	determine	determine	VB	VB	_	12	xcomp	_	_
15	which	which	WDT	WDT	_	18	dep	_	_
16	viral	viral	JJ	JJ	_	18	amod	_	_
17	peptide	peptide	NN	NN	_	18	compound	_	_
18	residues	residue	NNS	NNS	_	24	dep	_	_
19	contacting	contact	VBG	VBG	_	18	acl	_	_
20	TCR	tcr	NN	NN	_	19	dobj	_	_
21	might	might	MD	MD	_	24	aux	_	_
22	therefore	therefore	RB	RB	_	24	advmod	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	presented	present	VBN	VBN	_	14	ccomp	_	_
25	in	in	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	altered	altered	JJ	JJ	_	28	amod	_	_
28	conformation	conformation	NN	NN	_	24	nmod	_	_
29	by	by	IN	IN	_	30	case	_	_
30	DQA1*0201/DQB1*0201	dqa1*0201/dqb1*0201	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Residues	residue	NNS	NNS	_	25	nsubj	_	_
2	432	432	CD	CD	_	1	dep	_	_
3	,	,	,	,	_	1	punct	_	_
4	435	435	CD	CD	_	1	conj	_	_
5	,	,	,	,	_	1	punct	_	_
6	437	437	CD	CD	_	1	conj	_	_
7	,	,	,	,	_	1	punct	_	_
8	438	438	CD	CD	_	1	conj	_	_
9	,	,	,	,	_	1	punct	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	440	440	CD	CD	_	1	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	position	position	NN	NN	_	1	dep	_	_
14	P1	p1	NN	NN	_	13	dep	_	_
15	,	,	,	,	_	13	punct	_	_
16	P4	p4	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	P6	p6	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	13	punct	_	_
20	P7	p7	NN	NN	_	13	conj	_	_
21	,	,	,	,	_	13	punct	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	P9	p9	NN	NN	_	13	conj	_	_
24	)	)	-RRB-	-RRB-	_	13	punct	_	_
25	contributed	contribute	VBD	VBD	_	0	root	_	_
26	to	to	TO	TO	_	28	case	_	_
27	DQ2	dq2	NN	NN	_	28	compound	_	_
28	binding	binding	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	whereas	whereas	IN	IN	_	52	mark	_	_
31	residues	residue	NNS	NNS	_	52	nsubj	_	_
32	431	431	CD	CD	_	31	dep	_	_
33	,	,	,	,	_	31	punct	_	_
34	433	433	CD	CD	_	31	conj	_	_
35	,	,	,	,	_	31	punct	_	_
36	434	434	CD	CD	_	31	conj	_	_
37	,	,	,	,	_	31	punct	_	_
38	and	and	CC	CC	_	31	cc	_	_
39	436	436	CD	CD	_	31	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	positions	position	NNS	NNS	_	31	dep	_	_
42	P	p	NN	NN	_	41	dep	_	_
43	1	1	CD	CD	_	42	nummod	_	_
44	,	,	,	,	_	41	punct	_	_
45	P2	p2	NN	NN	_	41	conj	_	_
46	,	,	,	,	_	41	punct	_	_
47	P3	p3	NN	NN	_	41	conj	_	_
48	,	,	,	,	_	41	punct	_	_
49	and	and	CC	CC	_	41	cc	_	_
50	P5	p5	NN	NN	_	41	conj	_	_
51	)	)	-RRB-	-RRB-	_	41	punct	_	_
52	contributed	contribute	VBD	VBD	_	25	advcl	_	_
53	to	to	TO	TO	_	55	case	_	_
54	TCR	tcr	NN	NN	_	55	compound	_	_
55	contact	contact	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	25	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	presentation	presentation	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	peptide	peptide	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	HLA	hla	NN	NN	_	8	compound	_	_
7	DQ2	dq2	NN	NN	_	8	compound	_	_
8	heterodimers	heterodimer	NNS	NNS	_	2	nmod	_	_
9	varying	vary	VBG	VBG	_	8	acl	_	_
10	at	at	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DQA1	dqa1	NN	NN	_	13	compound	_	_
13	locus	locus	NN	NN	_	9	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	have	have	VB	VB	_	0	root	_	_
16	relevance	relevance	NN	NN	_	15	dobj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	host	host	NN	NN	_	19	compound	_	_
19	defense	defense	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	pathogenesis	pathogenesis	NN	NN	_	19	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	HLA	hla	NN	NN	_	27	compound	_	_
25	DQ2-associated	dq2-associated	JJ	JJ	_	27	amod	_	_
26	autoimmune	autoimmune	JJ	JJ	_	27	amod	_	_
27	diseases	disease	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	epsilon	epsilon	NN	NN	_	6	compound	_	_
5	germline	germline	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	1	nmod	_	_
7	:	:	:	:	_	1	punct	_	_
8	role	role	NN	NN	_	1	dep	_	_
9	of	of	IN	IN	_	12	case	_	_
10	B-cell-specific	b-cell-specific	JJ	JJ	_	12	amod	_	_
11	activator	activator	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Germline	germline	NN	NN	_	2	compound	_	_
2	transcripts	transcript	NNS	NNS	_	3	nsubj	_	_
3	initiate	initiate	VBP	VBP	_	0	root	_	_
4	from	from	IN	IN	_	5	case	_	_
5	promoters	promoter	NNS	NNS	_	3	nmod	_	_
6	upstream	upstream	RB	RB	_	5	advmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	immunoglobulin	immunoglobulin	NN	NN	_	11	compound	_	_
10	switch	switch	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	necessary	necessary	JJ	JJ	_	3	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	target	target	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	appropriate	appropriate	JJ	JJ	_	21	amod	_	_
20	switch	switch	NN	NN	_	21	compound	_	_
21	region	region	NN	NN	_	17	dobj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	recombination	recombination	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	switching	switching	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	cytokines	cytokine	NNS	NNS	_	3	nsubj	_	_
3	activate	activate	VBP	VBP	_	0	root	_	_
4	transcription	transcription	NN	NN	_	3	dobj	_	_
5	at	at	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	appropriate	appropriate	JJ	JJ	_	9	amod	_	_
8	germline	germline	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	12	mark	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	sites	site	NNS	NNS	_	12	nsubj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	B-cell-specific	b-cell-specific	JJ	JJ	_	7	amod	_	_
6	activator	activator	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	BSAP	bsap	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	located	located	JJ	JJ	_	28	advcl	_	_
13	upstream	upstream	RB	RB	_	12	advmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	several	several	JJ	JJ	_	17	amod	_	_
16	switch	switch	NN	NN	_	17	compound	_	_
17	regions	region	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	immunoglobulin	immunoglobulin	NN	NN	_	24	compound	_	_
21	heavy	heavy	JJ	JJ	_	24	amod	_	_
22	chain	chain	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	cluster	cluster	NN	NN	_	17	nmod	_	_
25	,	,	,	,	_	28	punct	_	_
26	BSAP	bsap	NN	NN	_	28	nsubj	_	_
27	might	might	MD	MD	_	28	aux	_	_
28	play	play	VB	VB	_	0	root	_	_
29	a	a	DT	DT	_	30	det	_	_
30	role	role	NN	NN	_	28	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	regulation	regulation	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	germline	germline	NN	NN	_	36	compound	_	_
36	transcription	transcription	NN	NN	_	33	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	isotype	isotype	NN	NN	_	39	compound	_	_
39	switching	switching	NN	NN	_	36	conj	_	_
40	.	.	.	.	_	28	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	5	mark	_	_
4	BSAP	bsap	NN	NN	_	5	nsubj	_	_
5	plays	play	VBZ	VBZ	_	2	ccomp	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	epsilon	epsilon	NN	NN	_	11	nmod	_	_
15	germline	germline	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	14	dep	_	_
17	in	in	IN	IN	_	20	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	BSAP	bsap	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	IL-4-dependent	il-4-dependent	JJ	JJ	_	12	amod	_	_
12	induction	induction	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CD40-mediated	cd40-mediated	JJ	JJ	_	15	amod	_	_
15	upregulation	upregulation	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	epsilon	epsilon	NN	NN	_	20	compound	_	_
19	germline	germline	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	12	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	BSAP	bsap	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	unique	unique	JJ	JJ	_	0	root	_	_
4	among	among	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	3	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	regulate	regulate	VBP	VBP	_	7	acl:relcl	_	_
10	epsilon	epsilon	NN	NN	_	12	compound	_	_
11	germline	germline	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	3	punct	_	_
14	because	because	IN	IN	_	19	mark	_	_
15	it	it	PRP	PRP	_	19	nsubj	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	B	b	NN	NN	_	19	nmod:npmod	_	_
18	cell	cell	NN	NN	_	19	nmod:npmod	_	_
19	specific	specific	JJ	JJ	_	3	advcl	_	_
20	,	,	,	,	_	19	punct	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	at	at	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	merging	merging	JJ	JJ	_	26	amod	_	_
26	point	point	NN	NN	_	19	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	two	two	CD	CD	_	30	nummod	_	_
29	signalling	signalling	NN	NN	_	30	compound	_	_
30	pathways	pathway	NNS	NNS	_	26	nmod	_	_
31	that	that	WDT	WDT	_	33	nsubj	_	_
32	are	be	VBP	VBP	_	33	cop	_	_
33	critical	critical	JJ	JJ	_	30	acl:relcl	_	_
34	for	for	IN	IN	_	36	case	_	_
35	IgE	ige	NN	NN	_	36	compound	_	_
36	switching	switching	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	3	amod	_	_
2	acid-induced	acid-induced	JJ	JJ	_	3	amod	_	_
3	modulation	modulation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-2	il-2	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	3	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Retinoic	retinoic	JJ	JJ	_	4	amod	_	_
4	acid	acid	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	RA	ra	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	has	have	VBZ	VBZ	_	1	dep	_	_
9	important	important	JJ	JJ	_	11	amod	_	_
10	immune-modulating	immune-modulating	JJ	JJ	_	9	dep	_	_
11	effects	effect	NNS	NNS	_	8	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	T	t	NN	NN	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	B	b	NN	NN	_	14	conj	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	14	dep	_	_
19	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	laboratory	laboratory	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	RA	ra	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	enhance	enhance	VB	VB	_	4	ccomp	_	_
9	in	in	FW	FW	_	18	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	polyclonal	polyclonal	JJ	JJ	_	9	dep	_	_
12	B	b	NN	NN	_	18	compound	_	_
13	cell	cell	NN	NN	_	18	compound	_	_
14	immunoglobulin	immunoglobulin	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	Ig	ig	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	response	response	NN	NN	_	8	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Investigating	investigate	VBG	VBG	_	0	root	_	_
2	cytokines	cytokine	NNS	NNS	_	1	dobj	_	_
3	known	know	VBN	VBN	_	2	acl	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	affect	affect	VB	VB	_	3	xcomp	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	1	punct	_	_
10	we	we	PRP	PRP	_	13	nsubj	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	recently	recently	RB	RB	_	13	advmod	_	_
13	shown	show	VBN	VBN	_	1	parataxis	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	IL-6	il-6	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	augmented	augment	VBN	VBN	_	13	ccomp	_	_
19	by	by	IN	IN	_	20	case	_	_
20	RA	ra	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	examined	examine	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	modulating	modulating	JJ	JJ	_	11	amod	_	_
11	effects	effect	NNS	NNS	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	RA	ra	NN	NN	_	11	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	another	another	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	cytokine	cytokine	NN	NN	_	16	appos	_	_
21	for	for	IN	IN	_	25	case	_	_
22	B	b	NN	NN	_	25	compound	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	immunoglobulin	immunoglobulin	NN	NN	_	25	compound	_	_
25	production	production	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	11	punct	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	11	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	IL-2	il-2	NN	NN	_	31	compound	_	_
31	receptors	receptor	NNS	NNS	_	28	nmod	_	_
32	on	on	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	,	,	,	,	_	11	punct	_	_
36	and	and	CC	CC	_	11	cc	_	_
37	the	the	DT	DT	_	40	det	_	_
38	RA	ra	NN	NN	_	40	compound	_	_
39	nuclear	nuclear	JJ	JJ	_	40	amod	_	_
40	receptors	receptor	NNS	NNS	_	11	conj	_	_
41	.	.	.	.	_	7	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Purified	purify	VBN	VBN	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	obtained	obtain	VBN	VBN	_	1	dep	_	_
8	from	from	IN	IN	_	10	case	_	_
9	adenoidal	adenoidal	JJ	JJ	_	10	amod	_	_
10	tissues	tissue	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	incubated	incubate	VBN	VBN	_	7	conj	_	_
14	with	with	IN	IN	_	15	case	_	_
15	RA	ra	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	10(-7)	10(-7)	CD	CD	_	18	nummod	_	_
18	M	m	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	or	or	CC	CC	_	15	cc	_	_
21	DMSO	dmso	NN	NN	_	23	compound	_	_
22	solvent/media	solvent/media	NN	NN	_	23	compound	_	_
23	control	control	NN	NN	_	15	conj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	0	0	CD	CD	_	13	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	6-8	6-8	CD	CD	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	24	24	CD	CD	_	25	conj	_	_
31	h	h	NN	NN	_	25	dep	_	_
32	.	.	.	.	_	1	punct	_	_

1	Total	total	JJ	JJ	_	2	amod	_	_
2	mRNA	mrna	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	extracted	extract	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	using	use	VBG	VBG	_	4	conj	_	_
11	RT-PCR	rt-pcr	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	10	punct	_	_
13	changes	change	NNS	NNS	_	32	nsubjpass	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	production	production	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IL-2	il-2	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	RA	ra	NN	NN	_	21	compound	_	_
21	receptors	receptor	NNS	NNS	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RAR	rar	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	-alpha	-alpha	NN	NN	_	18	conj	_	_
26	,	,	,	,	_	25	punct	_	_
27	beta	beta	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	25	punct	_	_
29	gamma	gamma	NN	NN	_	25	appos	_	_
30	mRNA	mrna	NN	NN	_	29	dep	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	determined	determine	VBN	VBN	_	10	parataxis	_	_
33	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RA	ra	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	IL-2-alpha	il-2-alpha	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	determined	determine	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	flow	flow	NN	NN	_	13	compound	_	_
13	cytometry	cytometry	NN	NN	_	10	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	RA	ra	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	augment	augment	VB	VB	_	5	ccomp	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	dobj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	possible	possible	JJ	JJ	_	20	amod	_	_
19	paracrine	paracrine	NN	NN	_	20	compound	_	_
20	effect	effect	NN	NN	_	9	nmod	_	_
21	on	on	IN	IN	_	23	case	_	_
22	IL-2R-alpha	il-2r-alpha	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	changes	change	NNS	NNS	_	3	nsubj	_	_
3	appear	appear	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	3	xcomp	_	_
7	by	by	IN	IN	_	8	case	_	_
8	RAR-alpha	rar-alpha	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	IL-2	il-2	NN	NN	_	8	nsubj	_	_
4	may	may	MD	MD	_	8	aux	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	another	another	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	0	root	_	_
9	modulated	modulate	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	RA	ra	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Itk	itk	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	T	t	NN	NN	_	7	compound	_	_
5	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	1	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	15	case	_	_
12	CD2-mediated	cd2-mediated	JJ	JJ	_	14	amod	_	_
13	interleukin-2	interleukin-2	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	T	t	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	Jurkat	jurkat	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Itk	itk	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	10	det	_	_
10	member	member	NN	NN	_	7	appos	_	_
11	of	of	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
14	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
15	kinase	kinase	NN	NN	_	17	compound	_	_
16	Tec	tec	NN	NN	_	17	compound	_	_
17	family	family	NN	NN	_	10	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	in	in	IN	IN	_	22	case	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	5	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	either	either	CC	CC	_	4	cc:preconj	_	_
4	CD2	cd2	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	TCR	tcr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	/CD3	/cd3	NN	NN	_	4	conj	_	_
13	on	on	IN	IN	_	14	case	_	_
14	Tcells	tcell	NNS	NNS	_	1	nmod	_	_
15	by	by	IN	IN	_	18	case	_	_
16	monoclonal	monoclonal	JJ	JJ	_	18	amod	_	_
17	antibody-mediated	antibody-mediated	JJ	JJ	_	16	dep	_	_
18	cross-linking	cross-linking	NN	NN	_	1	nmod	_	_
19	induced	induce	VBD	VBD	_	0	root	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Itk	itk	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	19	punct	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	maximal	maximal	JJ	JJ	_	19	dep	_	_
28	as	as	RB	RB	_	29	advmod	_	_
29	early	early	RB	RB	_	27	advmod	_	_
30	as	as	IN	IN	_	32	case	_	_
31	1	1	CD	CD	_	32	nummod	_	_
32	min	min	NN	NN	_	29	nmod	_	_
33	after	after	IN	IN	_	32	case	_	_
34	stimulation	stimulation	NN	NN	_	32	dep	_	_
35	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	11	nsubjpass	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	anti-Itk	anti-itk	JJ	JJ	_	8	amod	_	_
8	immunoprecipitate	immunoprecipitate	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	activated	activate	VBN	VBN	_	0	root	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	stimulations	stimulation	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-2	il-2	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	21	nsubjpass	_	_
7	stimulated	stimulate	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	cross-linking	cross-linking	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD2	cd2	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	TCR/CD3	tcr/cd3	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	CD28	cd28	NN	NN	_	11	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	antibodies	antibody	NNS	NNS	_	7	nmod	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	significantly	significantly	RB	RB	_	21	advmod	_	_
21	reduced	reduce	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	24	case	_	_
23	transient	transient	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	Itk	itk	NN	NN	_	28	compound	_	_
28	mutant	mutant	NN	NN	_	24	nmod	_	_
29	lacking	lack	VBG	VBG	_	28	acl	_	_
30	the	the	DT	DT	_	32	det	_	_
31	kinase	kinase	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	3	nsubj	_	_
3	paralleled	parallel	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	decrease	decrease	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	endogenous	endogenous	JJ	JJ	_	12	amod	_	_
11	wild-type	wild-type	JJ	JJ	_	12	amod	_	_
12	Itk	itk	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD2	cd2	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	TCR/CD3	tcr/cd3	NN	NN	_	3	conj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	activation	activation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	of	of	IN	IN	_	15	amod	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	NFAT	nfat	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	binding	bind	VBG	VBG	_	22	amod	_	_
22	site	site	NN	NN	_	26	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	22	nmod	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	included	include	VBN	VBN	_	15	acl:relcl	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	IL-2	il-2	NN	NN	_	31	compound	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFAT	nfat	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	impaired	impair	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	expression	expression	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Itk	itk	NN	NN	_	13	compound	_	_
13	mutant	mutant	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Itk	itk	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	indicating	indicate	VBG	VBG	_	6	advcl	_	_
14	a	a	DT	DT	_	16	det	_	_
15	critical	critical	JJ	JJ	_	16	amod	_	_
16	involvement	involvement	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Itk	itk	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	initial	initial	JJ	JJ	_	22	amod	_	_
22	stage	stage	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	mediating	mediate	VBG	VBG	_	16	acl	_	_
29	signals	signal	NNS	NNS	_	28	dobj	_	_
30	from	from	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	TCR/CD3	tcr/cd3	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	CD2	cd2	NN	NN	_	33	conj	_	_
36	,	,	,	,	_	33	punct	_	_
37	and	and	CC	CC	_	33	cc	_	_
38	CD28	cd28	NN	NN	_	33	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	Jak3	jak3	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	associated	associate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	CD40	cd40	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	critical	critical	JJ	JJ	_	3	conj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	CD40	cd40	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	CD40	cd40	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	receptor	receptor	NN	NN	_	0	root	_	_
5	that	that	WDT	WDT	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	critical	critical	JJ	JJ	_	4	acl:relcl	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	survival	survival	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	growth	growth	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	differentiation	differentiation	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	isotype	isotype	NN	NN	_	18	compound	_	_
18	switching	switching	NN	NN	_	10	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	CD40	cd40	NN	NN	_	3	nsubj	_	_
3	lacks	lack	VBZ	VBZ	_	11	advcl	_	_
4	intrinsic	intrinsic	JJ	JJ	_	7	amod	_	_
5	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	11	punct	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	ligation	ligation	NN	NN	_	11	nsubj	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	necessary	necessary	JJ	JJ	_	14	acl:relcl	_	_
19	for	for	IN	IN	_	22	case	_	_
20	several	several	JJ	JJ	_	22	amod	_	_
21	CD40-mediated	cd40-mediated	JJ	JJ	_	22	amod	_	_
22	events	event	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	engagement	engagement	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD40	cd40	NN	NN	_	4	nmod	_	_
7	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activation	activation	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Jak3	jak3	NN	NN	_	9	nmod	_	_
14	as	as	RB	RB	_	13	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	of	of	IN	IN	_	18	case	_	_
18	STAT3	stat3	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	Jak3	jak3	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	constitutively	constitutively	RB	RB	_	4	advmod	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	CD40	cd40	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	this	this	DT	DT	_	10	det	_	_
10	interaction	interaction	NN	NN	_	11	nsubj	_	_
11	requires	require	VBZ	VBZ	_	4	conj	_	_
12	a	a	DT	DT	_	14	det	_	_
13	proline-rich	proline-rich	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	membrane-proximal	membrane-proximal	JJ	JJ	_	18	amod	_	_
18	region	region	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	CD40	cd40	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Deletion	deletion	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	sequence	sequence	NN	NN	_	1	nmod	_	_
5	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	capacity	capacity	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CD40	cd40	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	7	acl	_	_
12	expression	expression	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CD23	cd23	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	ICAM-1	icam-1	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	lymphotoxin-alpha	lymphotoxin-alpha	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	14	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	11	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	signaling	signaling	NN	NN	_	9	nsubjpass	_	_
6	through	through	IN	IN	_	7	case	_	_
7	Jak3	jak3	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	3	ccomp	_	_
10	by	by	IN	IN	_	11	case	_	_
11	CD40	cd40	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	plays	play	VBZ	VBZ	_	9	conj	_	_
14	an	a	DT	DT	_	16	det	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	role	role	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	CD40-mediated	cd40-mediated	JJ	JJ	_	19	amod	_	_
19	functions	function	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Structure	structure	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	function	function	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	13	case	_	_
6	the	the	DT	DT	_	13	det	_	_
7	human	human	JJ	JJ	_	13	amod	_	_
8	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
9	cell	cell	NN	NN	_	13	compound	_	_
10	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
11	differentiation	differentiation	NN	NN	_	13	compound	_	_
12	antigen	antigen	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	1	nmod	_	_
14	:	:	:	:	_	1	punct	_	_
15	evidence	evidence	NN	NN	_	1	dep	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Sp1	sp1	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	not	not	RB	RB	_	24	neg	_	_
23	of	of	IN	IN	_	24	case	_	_
24	c-Myb	c-myb	NN	NN	_	20	conj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	PU.1	pu.1	NN	NN	_	24	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	myelomonocytic	myelomonocytic	JJ	JJ	_	30	amod	_	_
29	lineage-specific	lineage-specific	JJ	JJ	_	30	amod	_	_
30	expression	expression	NN	NN	_	18	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	differentiation	differentiation	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	11	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	MNDA	mnda	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	specifically	specifically	RB	RB	_	11	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	maturing	mature	VBG	VBG	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	myelomonocytic	myelomonocytic	JJ	JJ	_	19	amod	_	_
19	lineage	lineage	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	in	in	IN	IN	_	22	case	_	_
22	monocytes	monocyte	NNS	NNS	_	15	conj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	granulocytes	granulocyte	NNS	NNS	_	22	conj	_	_
25	.	.	.	.	_	11	punct	_	_

1	Epitope	epitope	NN	NN	_	2	compound	_	_
2	enhancement	enhancement	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	confirm	confirm	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	strict	strict	JJ	JJ	_	9	amod	_	_
9	lineage-	lineage-	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	stage-specific	stage-specific	JJ	JJ	_	9	conj	_	_
12	expression	expression	NN	NN	_	9	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	MNDA	mnda	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	bone	bone	NN	NN	_	17	compound	_	_
17	marrow	marrow	NN	NN	_	9	nmod	_	_
18	as	as	RB	RB	_	17	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	in	in	IN	IN	_	25	case	_	_
22	other	other	JJ	JJ	_	25	amod	_	_
23	paraffin-embedded	paraffin-embedded	JJ	JJ	_	25	amod	_	_
24	fixed	fixed	JJ	JJ	_	23	dep	_	_
25	tissues	tissue	NNS	NNS	_	17	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	1-kb	1-kb	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	13	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	gene	gene	NN	NN	_	3	nmod	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	includes	include	VBZ	VBZ	_	3	acl:relcl	_	_
9	5'	5'	JJ	JJ	_	11	amod	_	_
10	flanking	flanking	JJ	JJ	_	11	amod	_	_
11	sequence	sequence	NN	NN	_	8	dobj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	reported	report	VBN	VBN	_	0	root	_	_
14	earlier	earlier	RBR	RBR	_	13	advmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	contain	contain	VB	VB	_	13	xcomp	_	_
17	functional	functional	JJ	JJ	_	19	amod	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	dobj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	specifically	specifically	RB	RB	_	23	advmod	_	_
23	demethylated	demethylate	VBN	VBN	_	13	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	expressing	express	VBG	VBG	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	contrast	contrast	NN	NN	_	23	nmod	_	_
29	to	to	TO	TO	_	31	case	_	_
30	null	null	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	13	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	revealed	reveal	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	this	this	DT	DT	_	8	det	_	_
7	1-kb	1-kb	JJ	JJ	_	8	amod	_	_
8	fragment	fragment	NN	NN	_	9	nsubj	_	_
9	promotes	promote	VBZ	VBZ	_	4	ccomp	_	_
10	higher	higher	JJR	JJR	_	13	amod	_	_
11	reporter	reporter	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	MNDA-expressing	mnda-expressing	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	than	than	IN	IN	_	19	case	_	_
18	non-expressing	non-expressing	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	indicating	indicate	VBG	VBG	_	9	advcl	_	_
22	cell-specific	cell-specific	JJ	JJ	_	23	amod	_	_
23	differences	difference	NNS	NNS	_	21	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	transactivation	transactivation	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	consensus	consensus	NN	NN	_	5	compound	_	_
5	elements	element	NNS	NNS	_	3	dobj	_	_
6	consistent	consistent	JJ	JJ	_	5	amod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	myeloid-specific	myeloid-specific	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	including	include	VBG	VBG	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	PU.1	pu.1	NN	NN	_	16	compound	_	_
15	consensus	consensus	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	5	nmod	_	_
17	near	near	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	major	major	JJ	JJ	_	22	amod	_	_
20	transcription	transcription	NN	NN	_	22	compound	_	_
21	start	start	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	16	nmod	_	_
23	and	and	CC	CC	_	16	cc	_	_
24	a	a	DT	DT	_	25	det	_	_
25	cluster	cluster	NN	NN	_	16	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	c-Myb	c-myb	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	25	nmod	_	_
29	located	located	JJ	JJ	_	25	amod	_	_
30	several	several	JJ	JJ	_	31	advmod	_	_
31	hundred	hundred	CD	CD	_	32	dep	_	_
32	bases	basis	NNS	NNS	_	33	dep	_	_
33	upstream	upstream	RB	RB	_	29	advmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	region	region	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	analysis	analysis	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	mutants	mutant	NNS	NNS	_	3	nmod	_	_
7	localized	localize	VBD	VBD	_	0	root	_	_
8	nearly	nearly	RB	RB	_	9	advmod	_	_
9	all	all	DT	DT	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	short	short	JJ	JJ	_	17	amod	_	_
17	region	region	NN	NN	_	7	nmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	-73	-73	CD	CD	_	21	nummod	_	_
20	to	to	TO	TO	_	21	dep	_	_
21	-16	-16	CD	CD	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	that	that	WDT	WDT	_	26	nsubj	_	_
24	did	do	VBD	VBD	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	include	include	VB	VB	_	17	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	cluster	cluster	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	c-Myb	c-myb	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	4-bp	4-bp	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	core	core	NN	NN	_	9	compound	_	_
7	Sp1	sp1	NN	NN	_	9	compound	_	_
8	consensus	consensus	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	GC	gc	NN	NN	_	12	compound	_	_
12	box	box	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	-20	-20	CD	CD	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	reduced	reduce	VBD	VBD	_	0	root	_	_
18	overall	overall	JJ	JJ	_	20	amod	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	1-kb	1-kb	JJ	JJ	_	24	amod	_	_
24	fragment	fragment	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	Mutation	mutation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	PU.1	pu.1	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	1	nmod	_	_
6	did	do	VBD	VBD	_	9	aux	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	affect	affect	VB	VB	_	0	root	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	Only	only	RB	RB	_	4	advmod	_	_
2	a	a	DT	DT	_	4	det	_	_
3	small	small	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	25	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	-35	-35	CD	CD	_	4	dep	_	_
7	to	to	TO	TO	_	8	case	_	_
8	+22	+22	CD	CD	_	6	nmod	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	including	include	VBG	VBG	_	4	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Sp1	sp1	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	start	start	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	13	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	PU.1	pu.1	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	13	conj	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	footprinted	footprint	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	4-bp	4-bp	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	core	core	NN	NN	_	3	nmod	_	_
7	Sp1	sp1	NN	NN	_	9	compound	_	_
8	consensus	consensus	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	6	dep	_	_
10	abolished	abolish	VBD	VBD	_	0	root	_	_
11	footprinting	footprinting	NN	NN	_	10	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	site	site	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	an	a	DT	DT	_	19	det	_	_
17	antibody	antibody	JJ	JJ	_	19	amod	_	_
18	super-shift	super-shift	JJ	JJ	_	19	amod	_	_
19	reaction	reaction	NN	NN	_	20	nsubj	_	_
20	showed	show	VBD	VBD	_	10	conj	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	Sp1	sp1	NN	NN	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	one	one	CD	CD	_	20	ccomp	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	binding	bind	VBG	VBG	_	27	acl	_	_
29	the	the	DT	DT	_	31	det	_	_
30	consensus	consensus	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	28	dobj	_	_
32	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Sp1	sp1	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	co-localizes	co-localize	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	DNase	dnase	NN	NN	_	11	compound	_	_
9	I	i	CD	CD	_	11	nummod	_	_
10	hypersensitive	hypersensitive	JJ	JJ	_	11	amod	_	_
11	site	site	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	methylation	methylation	NN	NN	_	17	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	chromatin	chromatin	NN	NN	_	9	compound	_	_
9	structure	structure	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	transactivation	transactivation	NN	NN	_	6	conj	_	_
13	at	at	IN	IN	_	16	case	_	_
14	an	a	DT	DT	_	16	det	_	_
15	Sp1	sp1	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	contribute	contribute	VBP	VBP	_	3	ccomp	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	highly	highly	RB	RB	_	21	advmod	_	_
21	restricted	restricted	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	this	this	DT	DT	_	28	det	_	_
25	myelomonocytic	myelomonocytic	JJ	JJ	_	28	amod	_	_
26	lineage	lineage	NN	NN	_	28	compound	_	_
27	specific	specific	JJ	JJ	_	28	amod	_	_
28	gene	gene	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TPA	tpa	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	bryostatin	bryostatin	NN	NN	_	3	conj	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	,	,	,	,	_	3	punct	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	retinoic	retinoic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	3	conj	_	_
11	on	on	IN	IN	_	12	case	_	_
12	PO-B	po-b	NN	NN	_	1	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	AP-1	ap-1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	AP-2	ap-2	NN	NN	_	12	conj	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	12	dep	_	_
20	during	during	IN	IN	_	22	case	_	_
21	HL-60	hl-60	NN	NN	_	22	compound	_	_
22	differentiation	differentiation	NN	NN	_	1	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	PO-B	po-b	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	originally	originally	RB	RB	_	4	advmod	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	pro-opiomelanocortin	pro-opiomelanocortin	JJ	JJ	_	16	amod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	POMC	pomc	JJ	JJ	_	16	amod	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	gene	gene	NN	NN	_	9	nmod	_	_
17	;	;	:	:	_	4	punct	_	_
18	however	however	RB	RB	_	22	advmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	it	it	PRP	PRP	_	22	nsubj	_	_
21	has	have	VBZ	VBZ	_	22	aux	_	_
22	become	become	VBN	VBN	_	4	parataxis	_	_
23	increasingly	increasingly	RB	RB	_	24	advmod	_	_
24	clear	clear	JJ	JJ	_	22	xcomp	_	_
25	that	that	IN	IN	_	30	mark	_	_
26	this	this	DT	DT	_	27	det	_	_
27	protein	protein	NN	NN	_	30	nsubj	_	_
28	may	may	MD	MD	_	30	aux	_	_
29	be	be	VB	VB	_	30	cop	_	_
30	active	active	JJ	JJ	_	22	ccomp	_	_
31	in	in	IN	IN	_	32	case	_	_
32	tissues	tissue	NNS	NNS	_	30	nmod	_	_
33	outside	outside	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	pituitary	pituitary	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	30	punct	_	_
37	since	since	IN	IN	_	40	mark	_	_
38	it	it	PRP	PRP	_	40	nsubj	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	present	present	JJ	JJ	_	30	advcl	_	_
41	in	in	IN	IN	_	44	case	_	_
42	diverse	diverse	JJ	JJ	_	44	amod	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	types	type	NNS	NNS	_	40	nmod	_	_
45	,	,	,	,	_	44	punct	_	_
46	including	include	VBG	VBG	_	51	case	_	_
47	differentiated	differentiate	VBN	VBN	_	51	amod	_	_
48	HL-60	hl-60	NN	NN	_	51	compound	_	_
49	promyelocytic	promyelocytic	JJ	JJ	_	51	amod	_	_
50	leukemia	leukemia	NN	NN	_	51	compound	_	_
51	cells	cell	NNS	NNS	_	44	nmod	_	_
52	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	PO-B	po-b	NN	NN	_	6	compound	_	_
6	DNA-binding	dna-binding	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	progressively	progressively	RB	RB	_	9	advmod	_	_
9	induced	induce	VBN	VBN	_	3	ccomp	_	_
10	during	during	IN	IN	_	11	case	_	_
11	differentiation	differentiation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	promyelomonocytic	promyelomonocytic	JJ	JJ	_	16	amod	_	_
14	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
15	HL-60	hl-60	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	acl	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	macrophage-like	macrophage-like	JJ	JJ	_	20	amod	_	_
20	lineage	lineage	NN	NN	_	11	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	with	with	IN	IN	_	24	case	_	_
23	phorbol	phorbol	NN	NN	_	24	compound	_	_
24	esters	ester	NNS	NNS	_	11	nmod	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	PO-B	po-b	NN	NN	_	6	compound	_	_
6	DNA-binding	dna-binding	NN	NN	_	12	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	HL-60	hl-60	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	similarly	similarly	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	3	ccomp	_	_
13	during	during	IN	IN	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	granulocytic	granulocytic	JJ	JJ	_	18	amod	_	_
18	lineage	lineage	NN	NN	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	with	with	IN	IN	_	23	case	_	_
21	either	either	CC	CC	_	23	cc:preconj	_	_
22	retinoic	retinoic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	14	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	dimethylsulfoxide	dimethylsulfoxide	NN	NN	_	23	conj	_	_
26	)	)	-RRB-	-RRB-	_	23	punct	_	_
27	.	.	.	.	_	3	punct	_	_

1	Either	either	CC	CC	_	3	cc:preconj	_	_
2	a	a	DT	DT	_	3	dep	_	_
3	genetic	genetic	JJ	JJ	_	10	nsubj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	pharmacologic	pharmacologic	JJ	JJ	_	3	conj	_	_
6	blockade	blockade	NN	NN	_	3	dep	_	_
7	of	of	IN	IN	_	9	case	_	_
8	HL-60	hl-60	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	3	nmod	_	_
10	prohibited	prohibit	VBD	VBD	_	0	root	_	_
11	these	these	DT	DT	_	13	det	_	_
12	inductive	inductive	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	10	dobj	_	_
14	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	prompted	prompt	VBN	VBN	_	0	root	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	interest	interest	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	dynamics	dynamics	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	other	other	JJ	JJ	_	14	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	changes	change	NNS	NNS	_	9	nmod	_	_
15	during	during	IN	IN	_	17	case	_	_
16	HL-60	hl-60	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	these	these	DT	DT	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	observed	observe	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	another	another	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	16	nsubjpass	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AP-1	ap-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	16	auxpass	_	_
14	also	also	RB	RB	_	16	advmod	_	_
15	robustly	robustly	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	5	ccomp	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	during	during	IN	IN	_	24	case	_	_
22	macrophage-like	macrophage-like	JJ	JJ	_	24	amod	_	_
23	HL-60	hl-60	NN	NN	_	24	compound	_	_
24	differentiation	differentiation	NN	NN	_	16	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	but	but	CC	CC	_	24	cc	_	_
27	not	not	RB	RB	_	30	neg	_	_
28	during	during	IN	IN	_	30	case	_	_
29	granulocytic	granulocytic	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	24	conj	_	_
31	.	.	.	.	_	5	punct	_	_

1	Conversely	conversely	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	DNA-binding	dna-binding	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	4	nmod	_	_
9	AP-2	ap-2	NN	NN	_	8	dep	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	slightly	slightly	RB	RB	_	12	advmod	_	_
12	reduced	reduce	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	TPA-induced	tpa-induced	JJ	JJ	_	16	amod	_	_
15	HL-60	hl-60	NN	NN	_	16	compound	_	_
16	differentiation	differentiation	NN	NN	_	12	nmod	_	_
17	but	but	CC	CC	_	12	cc	_	_
18	unchanged	unchanged	JJ	JJ	_	12	conj	_	_
19	during	during	IN	IN	_	21	case	_	_
20	granulocyte	granulocyte	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	conclude	conclude	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	PO-B	po-b	NN	NN	_	13	compound	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	general	general	JJ	JJ	_	17	amod	_	_
17	marker	marker	NN	NN	_	6	ccomp	_	_
18	of	of	IN	IN	_	21	case	_	_
19	HL-60	hl-60	NN	NN	_	21	compound	_	_
20	myelomonocytic	myelomonocytic	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	but	but	CC	CC	_	17	cc	_	_
24	that	that	IN	IN	_	41	mark	_	_
25	qualitative	qualitative	JJ	JJ	_	26	amod	_	_
26	aspects	aspect	NNS	NNS	_	41	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	induction	induction	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	additional	additional	JJ	JJ	_	34	amod	_	_
32	distinct	distinct	JJ	JJ	_	31	dep	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	29	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	such	such	JJ	JJ	_	38	case	_	_
37	as	as	IN	IN	_	36	mwe	_	_
38	AP-1	ap-1	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	26	punct	_	_
40	may	may	MD	MD	_	41	aux	_	_
41	contribute	contribute	VB	VB	_	17	conj	_	_
42	to	to	TO	TO	_	44	case	_	_
43	lineage-specific	lineage-specific	JJ	JJ	_	44	amod	_	_
44	determinants	determinant	NNS	NNS	_	41	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	fate	fate	NN	NN	_	44	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	Ikaros	ikaros	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	lymphocyte	lymphocyte	NN	NN	_	2	nmod	_	_
9	development	development	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	homeostasis	homeostasis	NN	NN	_	8	conj	_	_
12	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Ikaros	ikaros	NN	NN	_	3	compound	_	_
3	gene	gene	NN	NN	_	16	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	which	which	WDT	WDT	_	6	nsubj	_	_
6	encodes	encode	VBZ	VBZ	_	3	acl:relcl	_	_
7	a	a	DT	DT	_	8	det	_	_
8	family	family	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	hemopoietic-specific	hemopoietic-specific	JJ	JJ	_	13	amod	_	_
11	zinc	zinc	NN	NN	_	13	compound	_	_
12	finger	finger	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	described	describe	VBN	VBN	_	0	root	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	central	central	JJ	JJ	_	20	amod	_	_
20	regulator	regulator	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	lymphocyte	lymphocyte	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	16	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	fetal	fetal	JJ	JJ	_	3	amod	_	_
3	development	development	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	it	it	PRP	PRP	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	earliest	earliest	JJS	JJS	_	11	amod	_	_
11	stage	stage	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cell	cell	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cell	cell	NN	NN	_	14	conj	_	_
18	specification	specification	NN	NN	_	14	dep	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	adult	adult	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	however	however	RB	RB	_	9	advmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	lineages	lineage	NNS	NNS	_	9	nsubj	_	_
9	rely	rely	VBP	VBP	_	0	root	_	_
10	on	on	IN	IN	_	11	case	_	_
11	Ikaros	ikaros	NN	NN	_	9	nmod	_	_
12	at	at	IN	IN	_	14	case	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	phases	phase	NNS	NNS	_	9	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	activity	activity	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	essential	essential	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	generation	generation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cell	cell	NN	NN	_	7	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	16	neg	_	_
13	of	of	IN	IN	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	precursors	precursor	NNS	NNS	_	10	conj	_	_
17	,	,	,	,	_	4	punct	_	_
18	although	although	IN	IN	_	26	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	differentiation	differentiation	NN	NN	_	26	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	latter	latter	JJ	JJ	_	20	nmod	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	normal	normal	JJ	JJ	_	4	advcl	_	_
27	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	increase	increase	NN	NN	_	12	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	CD4	cd4	NN	NN	_	6	compound	_	_
6	thymocytes	thymocyte	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	immediate	immediate	JJ	JJ	_	10	amod	_	_
10	precursors	precursor	NNS	NNS	_	6	conj	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	because	because	IN	IN	_	18	mark	_	_
16	these	these	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	18	nsubj	_	_
18	lack	lack	VBP	VBP	_	33	advcl	_	_
19	markers	marker	NNS	NNS	_	18	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	correlate	correlate	VBP	VBP	_	19	acl:relcl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	positive	positive	JJ	JJ	_	24	amod	_	_
24	selection	selection	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	33	punct	_	_
26	a	a	DT	DT	_	27	det	_	_
27	deregulation	deregulation	NN	NN	_	33	nsubjpass	_	_
28	in	in	IN	IN	_	31	case	_	_
29	their	they	PRP$	PRP$	_	31	nmod:poss	_	_
30	maturation	maturation	NN	NN	_	31	compound	_	_
31	process	process	NN	NN	_	27	nmod	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	suggested	suggest	VBN	VBN	_	12	conj	_	_
34	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Ikaros-null	ikaros-null	JJ	JJ	_	4	amod	_	_
4	thymocytes	thymocyte	NNS	NNS	_	5	nsubj	_	_
5	hyperproliferate	hyperproliferate	VBP	VBP	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	15	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TCR	tcr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	signaling	signaling	NN	NN	_	7	nmod	_	_
16	;	;	:	:	_	5	punct	_	_
17	within	within	IN	IN	_	18	case	_	_
18	days	day	NNS	NNS	_	30	nmod	_	_
19	after	after	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	appearance	appearance	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	thymus	thymus	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	30	punct	_	_
26	clonally	clonally	RB	RB	_	27	advmod	_	_
27	expanding	expand	VBG	VBG	_	28	amod	_	_
28	populations	population	NNS	NNS	_	30	nsubjpass	_	_
29	are	be	VBP	VBP	_	30	auxpass	_	_
30	detected	detect	VBN	VBN	_	5	parataxis	_	_
31	.	.	.	.	_	5	punct	_	_

1	Deregulated	deregulated	JJ	JJ	_	3	amod	_	_
2	TCR-mediated	tcr-mediated	JJ	JJ	_	1	dep	_	_
3	responses	response	NNS	NNS	_	15	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	7	det	_	_
6	fast	fast	JJ	JJ	_	7	amod	_	_
7	kinetics	kinetics	NNS	NNS	_	3	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	tumor	tumor	NN	NN	_	10	compound	_	_
10	development	development	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	these	these	DT	DT	_	14	det	_	_
13	mutant	mutant	JJ	JJ	_	14	amod	_	_
14	thymocytes	thymocyte	NNS	NNS	_	3	nmod	_	_
15	implicate	implicate	VBP	VBP	_	0	root	_	_
16	Ikaros	ikaros	NN	NN	_	15	dobj	_	_
17	as	as	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	central	central	JJ	JJ	_	22	amod	_	_
20	tumor	tumor	NN	NN	_	22	compound	_	_
21	suppressor	suppressor	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	15	nmod	_	_
23	for	for	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lineage	lineage	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	lack	lack	NN	NN	_	21	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	natural	natural	JJ	JJ	_	8	amod	_	_
7	killer	killer	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	selective	selective	JJ	JJ	_	11	amod	_	_
11	defects	defect	NNS	NNS	_	4	conj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	gamma	gamma	NN	NN	_	16	compound	_	_
14	delta	delta	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	dendritic	dendritic	JJ	JJ	_	20	amod	_	_
19	antigen-presenting	antigen-presenting	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	point	point	VBP	VBP	_	0	root	_	_
22	to	to	TO	TO	_	23	case	_	_
23	Ikaros	ikaros	NN	NN	_	21	nmod	_	_
24	as	as	IN	IN	_	27	case	_	_
25	an	a	DT	DT	_	27	det	_	_
26	essential	essential	JJ	JJ	_	27	amod	_	_
27	factor	factor	NN	NN	_	21	nmod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	establishment	establishment	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	early	early	JJ	JJ	_	33	amod	_	_
33	branchpoints	branchpoint	NNS	NNS	_	30	nmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	T	t	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	pathway	pathway	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	dominant	dominant	JJ	JJ	_	4	amod	_	_
3	interference	interference	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Ikaros	ikaros	NN	NN	_	7	compound	_	_
7	isoforms	isoform	NNS	NNS	_	4	nmod	_	_
8	unable	unable	JJ	JJ	_	4	amod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	bind	bind	VB	VB	_	8	xcomp	_	_
11	DNA	dna	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	effects	effect	NNS	NNS	_	4	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	suggest	suggest	VBP	VBP	_	0	root	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	Ikaros	ikaros	NN	NN	_	21	nsubj	_	_
21	works	work	VBZ	VBZ	_	18	ccomp	_	_
22	in	in	IN	IN	_	23	case	_	_
23	concert	concert	NN	NN	_	21	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	other	other	JJ	JJ	_	26	amod	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Aiolos	aiolos	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	dep	_	_
7	lymphoid-restricted	lymphoid-restricted	JJ	JJ	_	4	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	structurally	structurally	RB	RB	_	10	advmod	_	_
10	related	related	JJ	JJ	_	7	conj	_	_
11	gene	gene	NN	NN	_	7	dep	_	_
12	,	,	,	,	_	2	punct	_	_
13	in	in	IN	IN	_	15	case	_	_
14	lymphoid	lymphoid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	2	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	discussed	discuss	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	model	model	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	proposed	propose	VBN	VBN	_	0	root	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	defines	define	VBZ	VBZ	_	4	dep	_	_
7	Ikaros	ikaros	NN	NN	_	6	dobj	_	_
8	as	as	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	backbone	backbone	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	complex	complex	JJ	JJ	_	16	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	network	network	NN	NN	_	10	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	controls	control	VBZ	VBZ	_	16	acl:relcl	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	fate	fate	NN	NN	_	21	compound	_	_
21	decisions	decision	NNS	NNS	_	18	dobj	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	regulates	regulate	VBZ	VBZ	_	18	conj	_	_
24	homeostasis	homeostasis	NN	NN	_	23	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	hemo-lymphoid	hemo-lymphoid	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Changes	change	NNS	NNS	_	7	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	network	network	NN	NN	_	1	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	reflect	reflect	VB	VB	_	0	root	_	_
8	differentiation	differentiation	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	proliferation	proliferation	NN	NN	_	8	conj	_	_
11	adjustments	adjustment	NNS	NNS	_	8	dep	_	_
12	made	make	VBN	VBN	_	8	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	hemo-lymphoid	hemo-lymphoid	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	precursors	precursor	NNS	NNS	_	15	conj	_	_
18	as	as	IN	IN	_	20	mark	_	_
19	they	they	PRP	PRP	_	20	nsubj	_	_
20	give	give	VBP	VBP	_	7	advcl	_	_
21	rise	rise	NN	NN	_	20	dobj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	our	we	PRP$	PRP$	_	28	nmod:poss	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	system	system	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Acute	acute	JJ	JJ	_	2	amod	_	_
2	leukemia	leukemia	NN	NN	_	0	root	_	_
3	with	with	IN	IN	_	5	case	_	_
4	promyelocytic	promyelocytic	JJ	JJ	_	5	amod	_	_
5	features	feature	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	PML/RARalpha	pml/raralpha	NN	NN	_	9	compound	_	_
8	transgenic	transgenic	JJ	JJ	_	9	amod	_	_
9	mice	mouse	NNS	NNS	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	promyelocytic	promyelocytic	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	APL	apl	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	reciprocal	reciprocal	JJ	JJ	_	12	amod	_	_
11	chromosomal	chromosomal	JJ	JJ	_	12	amod	_	_
12	translocations	translocation	NNS	NNS	_	8	nmod	_	_
13	involving	involve	VBG	VBG	_	12	acl	_	_
14	the	the	DT	DT	_	22	det	_	_
15	retinoic	retinoic	JJ	JJ	_	22	amod	_	_
16	acid	acid	NN	NN	_	22	compound	_	_
17	receptor	receptor	NN	NN	_	22	compound	_	_
18	alpha	alpha	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	RARalpha	raralpha	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	locus	locus	NN	NN	_	13	dobj	_	_
23	on	on	IN	IN	_	24	case	_	_
24	chromosome	chromosome	NN	NN	_	22	nmod	_	_
25	17	17	CD	CD	_	24	nummod	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	majority	majority	NN	NN	_	8	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cases	case	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	RARalpha	raralpha	NN	NN	_	8	nsubj	_	_
8	translocates	translocate	VBZ	VBZ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	fuses	fuse	VBZ	VBZ	_	8	conj	_	_
11	with	with	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	promyelocytic	promyelocytic	JJ	JJ	_	18	amod	_	_
14	leukemia	leukemia	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	PML	pml	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	gene	gene	NN	NN	_	10	nmod	_	_
19	located	located	JJ	JJ	_	18	amod	_	_
20	on	on	IN	IN	_	21	case	_	_
21	chromosome	chromosome	NN	NN	_	19	nmod	_	_
22	15	15	CD	CD	_	21	nummod	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	resulting	result	VBG	VBG	_	4	amod	_	_
3	fusion	fusion	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	5	nsubj	_	_
5	encode	encode	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	10	dep	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	structurally	structurally	RB	RB	_	9	advmod	_	_
9	unique	unique	JJ	JJ	_	10	amod	_	_
10	PML/RARalpha	pml/raralpha	NN	NN	_	5	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	RARalpha/PML	raralpha/pml	NN	NN	_	14	compound	_	_
13	fusion	fusion	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	10	conj	_	_
15	as	as	RB	RB	_	10	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	aberrant	aberrant	JJ	JJ	_	21	amod	_	_
19	PML	pml	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	products	product	NNS	NNS	_	10	conj	_	_
22	,	,	,	,	_	21	punct	_	_
23	the	the	DT	DT	_	26	det	_	_
24	respective	respective	JJ	JJ	_	26	amod	_	_
25	pathogenetic	pathogenetic	JJ	JJ	_	24	dep	_	_
26	roles	role	NNS	NNS	_	32	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	26	nmod	_	_
29	have	have	VBP	VBP	_	32	aux	_	_
30	not	not	RB	RB	_	32	neg	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	elucidated	elucidate	VBN	VBN	_	21	acl:relcl	_	_
33	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	transgenic	transgenic	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	14	nmod	_	_
8	the	the	DT	DT	_	11	det	_	_
9	PML/RARalpha	pml/raralpha	NN	NN	_	11	compound	_	_
10	fusion	fusion	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	specifically	specifically	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	5	acl:relcl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	myeloid-promyelocytic	myeloid-promyelocytic	JJ	JJ	_	18	amod	_	_
18	lineage	lineage	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	year	year	NN	NN	_	13	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	life	life	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	all	all	PDT	PDT	_	12	det:predet	_	_
9	the	the	DT	DT	_	12	det	_	_
10	PML/RARalpha	pml/raralpha	NN	NN	_	12	compound	_	_
11	transgenic	transgenic	JJ	JJ	_	12	amod	_	_
12	mice	mouse	NNS	NNS	_	13	nsubj	_	_
13	have	have	VBP	VBP	_	0	root	_	_
14	an	a	DT	DT	_	16	det	_	_
15	abnormal	abnormal	JJ	JJ	_	16	amod	_	_
16	hematopoiesis	hematopoiesis	NN	NN	_	13	dobj	_	_
17	that	that	WDT	WDT	_	21	nsubjpass	_	_
18	can	can	MD	MD	_	21	aux	_	_
19	best	best	RB	RB	_	21	advmod	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	described	describe	VBN	VBN	_	16	acl:relcl	_	_
22	as	as	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	myeloproliferative	myeloproliferative	JJ	JJ	_	25	amod	_	_
25	disorder	disorder	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Between	between	IN	IN	_	2	amod	_	_
2	12	12	CD	CD	_	5	nummod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	14	14	CD	CD	_	2	conj	_	_
5	months	month	NNS	NNS	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	age	age	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	them	they	PRP	PRP	_	10	nmod	_	_
13	develop	develop	VBP	VBP	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	form	form	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	acute	acute	JJ	JJ	_	18	amod	_	_
18	leukemia	leukemia	NN	NN	_	15	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	differentiation	differentiation	NN	NN	_	22	compound	_	_
22	block	block	NN	NN	_	18	nmod	_	_
23	at	at	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	promyelocytic	promyelocytic	JJ	JJ	_	26	amod	_	_
26	stage	stage	NN	NN	_	22	nmod	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	closely	closely	RB	RB	_	29	advmod	_	_
29	mimics	mimic	VBZ	VBZ	_	15	acl:relcl	_	_
30	human	human	JJ	JJ	_	31	amod	_	_
31	APL	apl	NN	NN	_	29	dobj	_	_
32	even	even	RB	RB	_	35	advmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
35	response	response	NN	NN	_	29	nmod	_	_
36	to	to	TO	TO	_	38	case	_	_
37	retinoic	retinoic	JJ	JJ	_	38	amod	_	_
38	acid	acid	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	7	nsubj	_	_
3	are	be	VBP	VBP	_	7	cop	_	_
4	conclusive	conclusive	JJ	JJ	_	7	amod	_	_
5	in	in	FW	FW	_	4	dep	_	_
6	vivo	vivo	FW	FW	_	5	dep	_	_
7	evidence	evidence	NN	NN	_	0	root	_	_
8	that	that	IN	IN	_	10	mark	_	_
9	PML/RARalpha	pml/raralpha	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	7	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	crucial	crucial	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pathogenesis	pathogenesis	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	APL	apl	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	CD95	cd95	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	Fas	fas	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	ligand	ligand	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	TCR-mediated	tcr-mediated	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	events	event	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Stimulation	stimulation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	mature	mature	JJ	JJ	_	6	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	TCR	tcr	NN	NN	_	9	compound	_	_
9	engagement	engagement	NN	NN	_	1	nmod	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	signals	signal	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	drive	drive	VBP	VBP	_	14	acl:relcl	_	_
17	induction	induction	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	cytokine	cytokine	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	clonal	clonal	JJ	JJ	_	24	amod	_	_
24	expansion	expansion	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	under	under	IN	IN	_	5	case	_	_
4	some	some	DT	DT	_	5	det	_	_
5	conditions	condition	NNS	NNS	_	11	nmod	_	_
6	,	,	,	,	_	11	punct	_	_
7	engagement	engagement	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	TCR	tcr	NN	NN	_	7	nmod	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	instead	instead	RB	RB	_	11	advmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	TCR-stimulated	tcr-stimulated	JJ	JJ	_	6	amod	_	_
6	apoptosis	apoptosis	NN	NN	_	7	nsubj	_	_
7	requires	require	VBZ	VBZ	_	3	ccomp	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	CD95	cd95	NN	NN	_	11	compound	_	_
11	ligand	ligand	NN	NN	_	8	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	followed	follow	VBN	VBN	_	8	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	interaction	interaction	NN	NN	_	16	nmod	_	_
20	between	between	IN	IN	_	22	case	_	_
21	CD95	cd95	NN	NN	_	22	compound	_	_
22	ligand	ligand	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	CD95	cd95	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	22	conj	_	_
27	also	also	RB	RB	_	28	advmod	_	_
28	expressed	express	VBN	VBN	_	26	acl	_	_
29	on	on	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	population	population	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	8	nsubjpass	_	_
3	reported	report	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	study	study	NN	NN	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	designed	design	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	address	address	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	13	det	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	events	event	NNS	NNS	_	10	dobj	_	_
14	triggered	trigger	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	TCR	tcr	NN	NN	_	17	compound	_	_
17	engagement	engagement	NN	NN	_	14	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	important	important	JJ	JJ	_	13	acl:relcl	_	_
21	for	for	IN	IN	_	22	mark	_	_
22	regulating	regulate	VBG	VBG	_	20	advcl	_	_
23	CD95	cd95	NN	NN	_	24	compound	_	_
24	ligand	ligand	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	approach	approach	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	2	dobj	_	_
4	,	,	,	,	_	2	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	generated	generate	VBD	VBD	_	2	parataxis	_	_
7	a	a	DT	DT	_	10	det	_	_
8	luciferase	luciferase	NN	NN	_	10	compound	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	construct	construct	NN	NN	_	6	dobj	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	elements	element	NNS	NNS	_	11	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CD95	cd95	NN	NN	_	16	compound	_	_
16	ligand	ligand	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	5	det	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	described	describe	VBN	VBN	_	5	amod	_	_
5	mutant	mutant	NN	NN	_	1	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	Jurkat	jurkat	NN	NN	_	11	compound	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	show	show	VBP	VBP	_	1	parataxis	_	_
15	that	that	IN	IN	_	29	mark	_	_
16	proximal	proximal	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	events	event	NNS	NNS	_	29	nsubjpass	_	_
19	dependent	dependent	JJ	JJ	_	18	amod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	presence	presence	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	CD45	cd45	NN	NN	_	27	compound	_	_
26	tyrosine	tyrosine	NN	NN	_	27	compound	_	_
27	phosphatase	phosphatase	NN	NN	_	22	nmod	_	_
28	are	be	VBP	VBP	_	29	auxpass	_	_
29	required	require	VBN	VBN	_	14	ccomp	_	_
30	for	for	IN	IN	_	34	case	_	_
31	TCR-stimulated	tcr-stimulated	JJ	JJ	_	34	amod	_	_
32	CD95	cd95	NN	NN	_	33	compound	_	_
33	ligand	ligand	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	1	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	further	further	RB	RB	_	4	advmod	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	TCR-stimulated	tcr-stimulated	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	Ras	ras	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	4	ccomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	optimal	optimal	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	CD95	cd95	NN	NN	_	21	compound	_	_
21	ligand	ligand	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Next	next	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	an	a	DT	DT	_	5	det	_	_
5	effort	effort	NN	NN	_	18	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	5	acl	_	_
8	critical	critical	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	dobj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	regulate	regulate	VBP	VBP	_	10	acl:relcl	_	_
13	CD95	cd95	NN	NN	_	14	compound	_	_
14	ligand	ligand	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
19	a	a	DT	DT	_	25	det	_	_
20	cyclosporin	cyclosporin	NN	NN	_	25	compound	_	_
21	A-sensitive	a-sensitive	JJ	JJ	_	25	amod	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	factor-AT	factor-at	NN	NN	_	25	compound	_	_
24	response	response	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	18	dobj	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	promoter	promoter	NN	NN	_	29	compound	_	_
29	region	region	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	this	this	DT	DT	_	32	det	_	_
32	gene	gene	NN	NN	_	29	nmod	_	_
33	that	that	WDT	WDT	_	35	nsubj	_	_
34	is	be	VBZ	VBZ	_	35	cop	_	_
35	critical	critical	JJ	JJ	_	25	acl:relcl	_	_
36	for	for	IN	IN	_	41	case	_	_
37	optimal	optimal	JJ	JJ	_	41	amod	_	_
38	CD95	cd95	NN	NN	_	39	compound	_	_
39	ligand	ligand	NN	NN	_	41	compound	_	_
40	reporter	reporter	NN	NN	_	41	compound	_	_
41	activity	activity	NN	NN	_	35	nmod	_	_
42	in	in	IN	IN	_	45	case	_	_
43	stimulated	stimulate	VBN	VBN	_	45	amod	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	18	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	begin	begin	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	dissection	dissection	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	biochemical	biochemical	JJ	JJ	_	11	amod	_	_
11	events	event	NNS	NNS	_	7	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	lead	lead	VBP	VBP	_	11	acl:relcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	expression	expression	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	CD95	cd95	NN	NN	_	18	compound	_	_
18	ligand	ligand	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	a	a	DT	DT	_	22	det	_	_
21	required	required	JJ	JJ	_	22	amod	_	_
22	step	step	NN	NN	_	15	appos	_	_
23	for	for	IN	IN	_	25	case	_	_
24	TCR-induced	tcr-induced	JJ	JJ	_	25	amod	_	_
25	apoptosis	apoptosis	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	CD40	cd40	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	dep	_	_
4	functional	functional	JJ	JJ	_	6	amod	_	_
5	activation	activation	NN	NN	_	6	compound	_	_
6	antigen	antigen	NN	NN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	B7-independent	b7-independent	JJ	JJ	_	12	amod	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	costimulatory	costimulatory	JJ	JJ	_	12	amod	_	_
12	molecule	molecule	NN	NN	_	6	conj	_	_
13	on	on	IN	IN	_	17	case	_	_
14	normal	normal	JJ	JJ	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	lung	lung	NN	NN	_	17	compound	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	6	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	CD40	cd40	NN	NN	_	8	nsubj	_	_
2	is	be	VBZ	VBZ	_	8	cop	_	_
3	an	a	DT	DT	_	8	det	_	_
4	important	important	JJ	JJ	_	8	amod	_	_
5	signaling	signaling	NN	NN	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activation	activation	NN	NN	_	5	conj	_	_
8	Ag	ag	NN	NN	_	0	root	_	_
9	found	find	VBN	VBN	_	8	acl	_	_
10	on	on	IN	IN	_	14	case	_	_
11	certain	certain	JJ	JJ	_	14	amod	_	_
12	bone	bone	NN	NN	_	14	compound	_	_
13	marrow-derived	marrow-derived	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Recently	recently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	CD40	cd40	NN	NN	_	7	nsubjpass	_	_
4	also	also	RB	RB	_	7	advmod	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	7	xcomp	_	_
11	by	by	IN	IN	_	13	case	_	_
12	mesenchymal	mesenchymal	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	including	include	VBG	VBG	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Little	little	JJ	JJ	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	about	about	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CD40	cd40	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	fibroblasts	fibroblast	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	investigates	investigate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	hypothesis	hypothesis	NN	NN	_	4	dobj	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	CD40	cd40	NN	NN	_	15	nsubj	_	_
9	expressed	express	VBN	VBN	_	8	acl	_	_
10	on	on	IN	IN	_	12	case	_	_
11	lung	lung	NN	NN	_	12	compound	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	an	a	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	6	ccomp	_	_
16	structure	structure	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	mechanism	mechanism	NN	NN	_	15	conj	_	_
19	for	for	IN	IN	_	20	case	_	_
20	interaction	interaction	NN	NN	_	15	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	hemopoietic	hemopoietic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Communication	communication	NN	NN	_	10	nsubj	_	_
2	between	between	IN	IN	_	4	case	_	_
3	resident	resident	JJ	JJ	_	4	amod	_	_
4	tissue	tissue	NN	NN	_	1	nmod	_	_
5	fibroblasts	fibroblast	NNS	NNS	_	4	dep	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	conj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	necessary	necessary	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	normal	normal	JJ	JJ	_	14	amod	_	_
13	wound	wound	NN	NN	_	14	compound	_	_
14	healing	healing	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	pathologic	pathologic	JJ	JJ	_	10	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	resulting	result	VBG	VBG	_	19	advcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	tissue	tissue	NN	NN	_	24	compound	_	_
24	fibrosis	fibrosis	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Signaling	signaling	NN	NN	_	8	nsubj	_	_
2	through	through	IN	IN	_	3	case	_	_
3	CD40	cd40	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	soluble	soluble	JJ	JJ	_	7	amod	_	_
6	CD40	cd40	NN	NN	_	7	compound	_	_
7	ligand	ligand	NN	NN	_	3	nmod	_	_
8	stimulated	stimulate	VBD	VBD	_	0	root	_	_
9	fibroblast	fibroblast	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	8	punct	_	_
12	as	as	IN	IN	_	13	mark	_	_
13	evidenced	evidence	VBN	VBN	_	8	advcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	mobilization	mobilization	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	factor-kappaB	factor-kappab	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	by	by	IN	IN	_	21	case	_	_
21	induction	induction	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	proinflammatory	proinflammatory	JJ	JJ	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	chemoattractant	chemoattractant	JJ	JJ	_	24	conj	_	_
27	cytokines	cytokine	NNS	NNS	_	24	dep	_	_
28	IL-6	il-6	NN	NN	_	24	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	IL-8	il-8	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	8	punct	_	_

1	IFN-gamma-primed	ifn-gamma-primed	JJ	JJ	_	3	amod	_	_
2	lung	lung	NN	NN	_	3	compound	_	_
3	fibroblasts	fibroblast	NNS	NNS	_	4	nsubj	_	_
4	costimulate	costimulate	VBP	VBP	_	0	root	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
7	proliferation	proliferation	NN	NN	_	4	dobj	_	_
8	utilizing	utilize	VBG	VBG	_	4	xcomp	_	_
9	CD40	cd40	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	the	the	DT	DT	_	16	det	_	_
14	well-studied	well-studied	JJ	JJ	_	16	amod	_	_
15	costimulatory	costimulatory	JJ	JJ	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	9	conj	_	_
17	B7-1	b7-1	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	B7-2	b7-2	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	4	punct	_	_

1	Data	datum	NNS	NNS	_	4	nsubj	_	_
2	reported	report	VBN	VBN	_	1	acl	_	_
3	herein	herein	RB	RB	_	2	advmod	_	_
4	support	support	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	hypothesis	hypothesis	NN	NN	_	4	dobj	_	_
7	that	that	IN	IN	_	23	mark	_	_
8	cognate	cognate	JJ	JJ	_	9	amod	_	_
9	interactions	interaction	NNS	NNS	_	23	nsubj	_	_
10	between	between	IN	IN	_	12	case	_	_
11	tissue	tissue	NN	NN	_	12	compound	_	_
12	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	infiltrating	infiltrate	VBG	VBG	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	12	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	via	via	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD40/CD40L	cd40/cd40l	NN	NN	_	21	compound	_	_
21	pathway	pathway	NN	NN	_	9	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	augment	augment	VBP	VBP	_	6	ccomp	_	_
24	inflammation	inflammation	NN	NN	_	23	dobj	_	_
25	and	and	CC	CC	_	23	cc	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	promote	promote	VB	VB	_	23	conj	_	_
28	fibrogenesis	fibrogenesis	NN	NN	_	27	dobj	_	_
29	by	by	IN	IN	_	30	mark	_	_
30	activating	activate	VBG	VBG	_	27	advcl	_	_
31	both	both	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	types	type	NNS	NNS	_	30	dobj	_	_
34	.	.	.	.	_	4	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Stat3	stat3	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	interleukin-6-induced	interleukin-6-induced	JJ	JJ	_	7	amod	_	_
6	IgM	igm	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	B-cell	b-cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-6	il-6	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	an	a	DT	DT	_	9	det	_	_
7	important	important	JJ	JJ	_	9	amod	_	_
8	B-cell	b-cell	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	9	punct	_	_

1	IL-6	il-6	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	lymphoblastoid	lymphoblastoid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	SKW6.4	skw6.4	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	2	punct	_	_
12	leads	lead	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	16	case	_	_
14	increased	increase	VBN	VBN	_	16	amod	_	_
15	IgM	igm	NN	NN	_	16	compound	_	_
16	production	production	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	IL-6	il-6	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
8	activation	activation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	JAK1	jak1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	JAK2	jak2	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	7	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	chimeric	chimeric	JJ	JJ	_	4	amod	_	_
3	IL-6	il-6	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	34	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	comprised	comprise	VBD	VBD	_	4	acl	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	tail	tail	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	IL-6	il-6	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	subunit	subunit	NN	NN	_	10	nmod	_	_
16	gp130	gp130	NN	NN	_	15	dep	_	_
17	fused	fuse	VBN	VBN	_	10	acl	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	extracellular	extracellular	JJ	JJ	_	21	amod	_	_
21	domain	domain	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	30	case	_	_
23	the	the	DT	DT	_	30	det	_	_
24	epidermal	epidermal	JJ	JJ	_	30	amod	_	_
25	growth	growth	NN	NN	_	30	compound	_	_
26	factor	factor	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	EGF	egf	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	receptor	receptor	NN	NN	_	21	nmod	_	_
31	,	,	,	,	_	4	punct	_	_
32	was	be	VBD	VBD	_	34	auxpass	_	_
33	stably	stably	RB	RB	_	34	advmod	_	_
34	transfected	transfect	VBN	VBN	_	0	root	_	_
35	into	into	IN	IN	_	37	case	_	_
36	SKW6.4	skw6.4	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	34	punct	_	_

1	EGF	egf	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	IgM	igm	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	transfected	transfect	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	intact	intact	JJ	JJ	_	14	amod	_	_
12	gp130	gp130	NN	NN	_	14	compound	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	tail	tail	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	but	but	CC	CC	_	7	cc	_	_
17	not	not	RB	RB	_	20	neg	_	_
18	in	in	IN	IN	_	20	case	_	_
19	untransfected	untransfected	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	7	conj	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	cells	cell	NNS	NNS	_	20	conj	_	_
23	transfected	transfect	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	cytoplasmic	cytoplasmic	JJ	JJ	_	27	amod	_	_
27	tail	tail	NN	NN	_	23	nmod	_	_
28	lacking	lack	VBG	VBG	_	27	acl	_	_
29	all	all	DT	DT	_	32	det	_	_
30	four	four	CD	CD	_	32	nummod	_	_
31	signal	signal	NN	NN	_	32	compound	_	_
32	transducers	transducer	NNS	NNS	_	28	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	activators	activator	NNS	NNS	_	41	compound	_	_
35	of	of	IN	IN	_	41	amod	_	_
36	transcription	transcription	NN	NN	_	41	compound	_	_
37	(	(	-LRB-	-LRB-	_	41	punct	_	_
38	Stat	stat	NN	NN	_	41	compound	_	_
39	)	)	-RRB-	-RRB-	_	41	punct	_	_
40	binding	binding	NN	NN	_	41	compound	_	_
41	sites	site	NNS	NNS	_	32	conj	_	_
42	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	EGF	egf	NN	NN	_	4	compound	_	_
4	treatment	treatment	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	Stat3	stat3	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	transfected	transfect	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	intact	intact	JJ	JJ	_	16	amod	_	_
14	chimeric	chimeric	JJ	JJ	_	16	amod	_	_
15	EGF-gp130	egf-gp130	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	10	nmod	_	_
17	along	along	IN	IN	_	19	case	_	_
18	with	with	IN	IN	_	19	case	_	_
19	induction	induction	NN	NN	_	5	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	DNA-mobility	dna-mobility	JJ	JJ	_	22	amod	_	_
22	shift	shift	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	classical	classical	JJ	JJ	_	27	amod	_	_
26	interferon-gamma-activated	interferon-gamma-activated	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	0	root	_	_
3	further	further	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	relation	relation	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	Stat3	stat3	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	enhanced	enhance	VBN	VBN	_	12	amod	_	_
11	IgM	igm	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	determined	determine	VBD	VBD	_	2	parataxis	_	_
16	the	the	DT	DT	_	17	det	_	_
17	effect	effect	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	chimeric	chimeric	JJ	JJ	_	20	amod	_	_
20	gp130	gp130	NN	NN	_	17	nmod	_	_
21	on	on	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	17	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	genetic	genetic	JJ	JJ	_	28	amod	_	_
28	element	element	NN	NN	_	24	nmod	_	_
29	linked	link	VBN	VBN	_	28	acl	_	_
30	to	to	TO	TO	_	32	case	_	_
31	immunoglobulin	immunoglobulin	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	28	punct	_	_
34	namely	namely	RB	RB	_	39	advmod	_	_
35	the	the	DT	DT	_	39	det	_	_
36	immunoglobulin	immunoglobulin	NN	NN	_	39	compound	_	_
37	heavy	heavy	JJ	JJ	_	39	amod	_	_
38	chain	chain	NN	NN	_	39	compound	_	_
39	enhancer	enhancer	NN	NN	_	28	appos	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	IgH-enhancer	igh-enhancer	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	2	punct	_	_

1	Parental	parental	JJ	JJ	_	10	nsubjpass	_	_
2	as	as	RB	RB	_	1	cc	_	_
3	well	well	RB	RB	_	2	mwe	_	_
4	as	as	IN	IN	_	2	mwe	_	_
5	transfected	transfect	VBN	VBN	_	1	conj	_	_
6	SKW6.4	skw6.4	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	dep	_	_
8	were	be	VBD	VBD	_	10	auxpass	_	_
9	transiently	transiently	RB	RB	_	10	advmod	_	_
10	transfected	transfect	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	IgH-enhancer-luciferase	igh-enhancer-luciferase	JJ	JJ	_	14	amod	_	_
14	construct	construct	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IgH-luciferase	igh-luciferase	JJ	JJ	_	7	amod	_	_
7	construct	construct	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	ligation	ligation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	full-length	full-length	JJ	JJ	_	16	amod	_	_
15	chimeric	chimeric	JJ	JJ	_	16	amod	_	_
16	receptor	receptor	NN	NN	_	11	nmod	_	_
17	but	but	CC	CC	_	11	cc	_	_
18	not	not	RB	RB	_	22	neg	_	_
19	by	by	IN	IN	_	22	case	_	_
20	truncated	truncate	VBN	VBN	_	22	amod	_	_
21	gp130	gp130	NN	NN	_	22	compound	_	_
22	receptors	receptor	NNS	NNS	_	11	conj	_	_
23	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	gp130-induced	gp130-induced	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	abrogated	abrogate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Stat3EE	stat3ee	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	mutant	mutant	JJ	JJ	_	17	amod	_	_
17	Stat3	stat3	NN	NN	_	13	appos	_	_
18	incapable	incapable	JJ	JJ	_	17	amod	_	_
19	of	of	IN	IN	_	20	mark	_	_
20	binding	bind	VBG	VBG	_	18	advcl	_	_
21	DNA	dna	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	IL-6-induced	il-6-induced	JJ	JJ	_	7	amod	_	_
6	B-cell	b-cell	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	17	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	as	as	IN	IN	_	10	mark	_	_
10	measured	measure	VBN	VBN	_	17	dep	_	_
11	by	by	IN	IN	_	13	case	_	_
12	IgM	igm	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	17	punct	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	controlled	control	VBN	VBN	_	3	ccomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	Stat3	stat3	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Homodimerization	homodimerization	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	human	human	JJ	JJ	_	9	amod	_	_
5	interleukin	interleukin	NN	NN	_	9	compound	_	_
6	4	4	CD	CD	_	9	nummod	_	_
7	receptor	receptor	NN	NN	_	9	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	chain	chain	NN	NN	_	1	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	Cepsilon	cepsilon	NN	NN	_	13	compound	_	_
12	germline	germline	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	absence	absence	NN	NN	_	10	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	interleukin	interleukin	NN	NN	_	26	compound	_	_
23	2	2	CD	CD	_	26	nummod	_	_
24	receptor	receptor	NN	NN	_	26	compound	_	_
25	gamma	gamma	NN	NN	_	26	compound	_	_
26	chain	chain	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	10	nsubj	_	_
3	interleukin	interleukin	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL	il	NN	NN	_	2	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-4	-4	CD	CD	_	5	nummod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	IL-13	il-13	NN	NN	_	5	conj	_	_
10	play	play	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	critical	critical	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	10	advcl	_	_
16	Cepsilon	cepsilon	NN	NN	_	18	compound	_	_
17	germline	germline	NN	NN	_	18	compound	_	_
18	transcripts	transcript	NNS	NNS	_	15	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	IgE	ige	NN	NN	_	21	compound	_	_
21	isotype	isotype	NN	NN	_	22	compound	_	_
22	switching	switching	NN	NN	_	18	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	B	b	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	15	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-4	il-4	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	11	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL-4R	il-4r	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	composed	compose	VBN	VBN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	chains	chain	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	IL-4-binding	il-4-binding	JJ	JJ	_	19	amod	_	_
18	IL-4Ralpha	il-4ralpha	NN	NN	_	19	compound	_	_
19	chain	chain	NN	NN	_	14	appos	_	_
20	,	,	,	,	_	19	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	shared	share	VBN	VBN	_	19	acl:relcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	IL-13R	il-13r	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	19	punct	_	_
28	and	and	CC	CC	_	19	cc	_	_
29	the	the	DT	DT	_	34	det	_	_
30	IL-2Rgamma	il-2rgamma	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	34	punct	_	_
32	gammac	gammac	NN	NN	_	34	compound	_	_
33	)	)	-RRB-	-RRB-	_	34	punct	_	_
34	chain	chain	NN	NN	_	19	conj	_	_
35	,	,	,	,	_	34	punct	_	_
36	which	which	WDT	WDT	_	38	nsubjpass	_	_
37	is	be	VBZ	VBZ	_	38	auxpass	_	_
38	shared	share	VBN	VBN	_	34	acl:relcl	_	_
39	with	with	IN	IN	_	40	case	_	_
40	IL-7R	il-7r	NN	NN	_	38	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	IL-9R	il-9r	NN	NN	_	40	conj	_	_
43	,	,	,	,	_	40	punct	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	IL-15R	il-15r	NN	NN	_	40	conj	_	_
46	.	.	.	.	_	11	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	Cepsilon	cepsilon	NN	NN	_	5	compound	_	_
4	germline	germline	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IgE	ige	NN	NN	_	8	compound	_	_
8	isotype	isotype	NN	NN	_	9	compound	_	_
9	switching	switching	NN	NN	_	5	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	from	from	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	gammac	gammac	NN	NN	_	17	compound	_	_
17	chain	chain	NN	NN	_	18	compound	_	_
18	deficiency	deficiency	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Induction	induction	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Cepsilon	cepsilon	NN	NN	_	5	compound	_	_
4	germline	germline	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IL-4	il-4	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	lack	lack	VBP	VBP	_	10	acl:relcl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	gammac	gammac	NN	NN	_	15	compound	_	_
15	chain	chain	NN	NN	_	12	dobj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	involve	involve	VB	VB	_	0	root	_	_
18	signaling	signaling	NN	NN	_	17	dobj	_	_
19	via	via	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	IL-13R	il-13r	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	Alternatively	alternatively	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	IL-4Ralpha	il-4ralpha	NN	NN	_	5	compound	_	_
5	chain	chain	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	transduce	transduce	VB	VB	_	0	root	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	signals	signal	NNS	NNS	_	7	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	lead	lead	VBP	VBP	_	9	acl:relcl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	Cepsilon	cepsilon	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	independently	independently	RB	RB	_	15	advmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	association	association	NN	NN	_	16	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	chains	chain	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	28	mark	_	_
4	ligand-induced	ligand-induced	JJ	JJ	_	5	amod	_	_
5	homodimerization	homodimerization	NN	NN	_	28	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	chimeric	chimeric	JJ	JJ	_	9	amod	_	_
8	surface	surface	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	5	nmod	_	_
10	consisting	consist	VBG	VBG	_	9	acl	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	dep	_	_
13	extracellular	extracellular	JJ	JJ	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	transmembrane	transmembrane	JJ	JJ	_	13	conj	_	_
16	domains	domain	NNS	NNS	_	13	dep	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	erythropoietin	erythropoietin	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	13	nmod	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	intracellular	intracellular	JJ	JJ	_	25	amod	_	_
25	domain	domain	NN	NN	_	13	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	IL-4Ralpha	il-4ralpha	NN	NN	_	25	nmod	_	_
28	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
29	Janus	janus	NN	NN	_	30	compound	_	_
30	kinase	kinase	NN	NN	_	35	compound	_	_
31	1	1	CD	CD	_	30	nummod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	Jak1	jak1	NN	NN	_	30	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	activation	activation	NN	NN	_	28	dobj	_	_
36	,	,	,	,	_	35	punct	_	_
37	STAT6	stat6	NN	NN	_	38	compound	_	_
38	activation	activation	NN	NN	_	35	conj	_	_
39	,	,	,	,	_	35	punct	_	_
40	and	and	CC	CC	_	35	cc	_	_
41	Cepsilon	cepsilon	NN	NN	_	43	compound	_	_
42	germline	germline	NN	NN	_	43	compound	_	_
43	transcripts	transcript	NNS	NNS	_	35	conj	_	_
44	in	in	IN	IN	_	49	case	_	_
45	human	human	JJ	JJ	_	49	amod	_	_
46	B	b	NN	NN	_	49	compound	_	_
47	cell	cell	NN	NN	_	49	compound	_	_
48	line	line	NN	NN	_	49	compound	_	_
49	BJAB	bjab	NN	NN	_	28	nmod	_	_
50	.	.	.	.	_	2	punct	_	_

1	Disruption	disruption	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	Jak1-binding	jak1-binding	JJ	JJ	_	7	amod	_	_
5	proline-rich	proline-rich	JJ	JJ	_	7	amod	_	_
6	Box1	box1	NN	NN	_	7	compound	_	_
7	region	region	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IL-4Ralpha	il-4ralpha	NN	NN	_	7	nmod	_	_
10	abolished	abolish	VBD	VBD	_	0	root	_	_
11	signaling	signaling	NN	NN	_	10	dobj	_	_
12	by	by	IN	IN	_	15	case	_	_
13	this	this	DT	DT	_	15	det	_	_
14	chimeric	chimeric	JJ	JJ	_	15	amod	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	24	advmod	_	_
2	,	,	,	,	_	24	punct	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	24	nsubj	_	_
5	transfected	transfect	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	chimeric	chimeric	JJ	JJ	_	10	amod	_	_
9	CD8alpha/IL-4Ralpha	cd8alpha/il-4ralpha	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	expressed	express	VBN	VBN	_	10	acl:relcl	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	surface	surface	NN	NN	_	14	nmod	_	_
19	as	as	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	homodimer	homodimer	NN	NN	_	14	nmod	_	_
22	,	,	,	,	_	4	punct	_	_
23	constitutively	constitutively	RB	RB	_	24	advmod	_	_
24	expressed	express	VBD	VBD	_	0	root	_	_
25	Cepsilon	cepsilon	NN	NN	_	27	compound	_	_
26	germline	germline	NN	NN	_	27	compound	_	_
27	transcripts	transcript	NNS	NNS	_	24	dobj	_	_
28	.	.	.	.	_	24	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	homodimerization	homodimerization	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-4Ralpha	il-4ralpha	NN	NN	_	9	compound	_	_
9	chain	chain	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	transduce	transduce	VB	VB	_	11	xcomp	_	_
14	Jak1-dependent	jak1-dependent	JJ	JJ	_	16	amod	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	signals	signal	NNS	NNS	_	13	dobj	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	lead	lead	VBP	VBP	_	16	acl:relcl	_	_
19	to	to	TO	TO	_	22	case	_	_
20	IgE	ige	NN	NN	_	21	compound	_	_
21	isotype	isotype	NN	NN	_	22	compound	_	_
22	switching	switching	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	T-lymphocytes	t-lymphocyte	NNS	NNS	_	1	nmod	_	_
6	transduced	transduce	VBN	VBN	_	5	acl	_	_
7	with	with	IN	IN	_	10	case	_	_
8	HTLV-I	htlv-i	NN	NN	_	10	compound	_	_
9	Tax	tax	NN	NN	_	10	compound	_	_
10	mutants	mutant	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	different	different	JJ	JJ	_	14	amod	_	_
13	trans-activating	trans-activating	JJ	JJ	_	12	dep	_	_
14	phenotypes	phenotype	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Tax1	tax1	NN	NN	_	18	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	trans-activator	trans-activator	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	Human	human	JJ	JJ	_	12	amod	_	_
9	T-cell	t-cell	NN	NN	_	12	compound	_	_
10	leukemia	leukemia	NN	NN	_	12	compound	_	_
11	virus	virus	NN	NN	_	12	compound	_	_
12	type	type	NN	NN	_	5	nmod	_	_
13	I	i	CD	CD	_	12	nummod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HTLV-I	htlv-i	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	1	punct	_	_
18	induces	induce	VBZ	VBZ	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	many	many	JJ	JJ	_	24	amod	_	_
23	cellular	cellular	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	through	through	IN	IN	_	26	case	_	_
26	interaction	interaction	NN	NN	_	18	nmod	_	_
27	with	with	IN	IN	_	34	case	_	_
28	at	at	IN	IN	_	29	case	_	_
29	least	least	JJS	JJS	_	30	nmod:npmod	_	_
30	three	three	CD	CD	_	34	nummod	_	_
31	distinct	distinct	JJ	JJ	_	34	amod	_	_
32	cellular	cellular	JJ	JJ	_	34	amod	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	26	nmod	_	_
35	;	;	:	:	_	18	punct	_	_
36	CREB/ATF	creb/atf	NN	NN	_	18	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	NF-kappaB	nf-kappab	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	SRF	srf	NN	NN	_	36	conj	_	_
42	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	Tax1-induced	tax1-induced	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	considered	consider	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	13	mark	_	_
10	be	be	VB	VB	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	critical	critical	JJ	JJ	_	13	amod	_	_
13	event	event	NN	NN	_	8	xcomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	transformation	transformation	NN	NN	_	13	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	HTLV-I	htlv-i	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	each	each	DT	DT	_	9	det	_	_
7	Tax1-inducible	tax1-inducible	JJ	JJ	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	pathway	pathway	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	transformation	transformation	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	introduced	introduce	VBD	VBD	_	2	parataxis	_	_
16	Tax1	tax1	NN	NN	_	17	compound	_	_
17	mutants	mutant	NNS	NNS	_	15	dobj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	different	different	JJ	JJ	_	21	amod	_	_
20	trans-activating	trans-activating	JJ	JJ	_	19	dep	_	_
21	phenotypes	phenotype	NNS	NNS	_	17	nmod	_	_
22	into	into	IN	IN	_	25	case	_	_
23	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
24	blood	blood	NN	NN	_	25	compound	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	PBL	pbl	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	by	by	IN	IN	_	31	case	_	_
30	retroviral	retroviral	JJ	JJ	_	31	amod	_	_
31	vectors	vector	NNS	NNS	_	15	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	PBLs	pbl	NNS	NNS	_	1	nmod	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	activation	activation	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	5	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	promote	promote	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	growth	growth	NN	NN	_	18	compound	_	_
18	response	response	NN	NN	_	15	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	IL-2	il-2	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	29	advmod	_	_
2	,	,	,	,	_	29	punct	_	_
3	for	for	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	clonal	clonal	JJ	JJ	_	6	amod	_	_
6	expansion	expansion	NN	NN	_	29	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
9	T-cells	t-cell	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	which	which	WDT	WDT	_	15	nsubj	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	characteristic	characteristic	JJ	JJ	_	15	amod	_	_
15	result	result	NN	NN	_	6	acl:relcl	_	_
16	of	of	IN	IN	_	18	case	_	_
17	HTLV-I	htlv-i	NN	NN	_	18	compound	_	_
18	infection	infection	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	29	punct	_	_
20	activation	activation	NN	NN	_	29	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	CREB/ATF	creb/atf	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	SRF	srf	NN	NN	_	23	conj	_	_
26	pathways	pathway	NNS	NNS	_	23	dep	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	also	also	RB	RB	_	29	advmod	_	_
29	required	require	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	phosphatidylinositol	phosphatidylinositol	NN	NN	_	4	compound	_	_
4	3-kinase	3-kinase	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	NFAT	nfat	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Phosphatidylinositol	phosphatidylinositol	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	8	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PI3-K	pi3-k	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	implicated	implicate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	regulation	regulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	proliferation	proliferation	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	many	many	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	15	nmod	_	_
9	the	the	DT	DT	_	11	det	_	_
10	PI3-K	pi3-k	NN	NN	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	15	nsubj	_	_
12	,	,	,	,	_	11	punct	_	_
13	wortmannin	wortmannin	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	interferes	interfere	VBZ	VBZ	_	4	ccomp	_	_
16	with	with	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	mitogen-activated	mitogen-activated	JJ	JJ	_	21	amod	_	_
21	kinase	kinase	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	Erk2	erk2	NN	NN	_	21	appos	_	_
24	,	,	,	,	_	15	punct	_	_
25	after	after	IN	IN	_	32	case	_	_
26	T	t	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TcR	tcr	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	stimulation	stimulation	NN	NN	_	15	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	explore	explore	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PI3-K	pi3-k	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	created	create	VBD	VBD	_	3	parataxis	_	_
15	a	a	DT	DT	_	16	det	_	_
16	set	set	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	potentially	potentially	RB	RB	_	22	advmod	_	_
19	dominant	dominant	JJ	JJ	_	22	amod	_	_
20	negative	negative	JJ	JJ	_	22	amod	_	_
21	PI3-K	pi3-k	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	16	nmod	_	_
23	comprising	comprise	VBG	VBG	_	16	acl	_	_
24	individual	individual	JJ	JJ	_	23	dobj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	tandem	tandem	JJ	JJ	_	27	amod	_	_
27	domains	domain	NNS	NNS	_	24	conj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	regulatory	regulatory	JJ	JJ	_	32	amod	_	_
31	p85	p85	NN	NN	_	32	compound	_	_
32	subunit	subunit	NN	NN	_	24	nmod	_	_
33	and	and	CC	CC	_	14	cc	_	_
34	tested	test	VBD	VBD	_	14	conj	_	_
35	their	they	PRP$	PRP$	_	36	nmod:poss	_	_
36	effect	effect	NN	NN	_	34	dobj	_	_
37	on	on	IN	IN	_	40	case	_	_
38	downstream	downstream	JJ	JJ	_	40	amod	_	_
39	signaling	signaling	NN	NN	_	40	compound	_	_
40	events	event	NNS	NNS	_	36	nmod	_	_
41	like	like	IN	IN	_	42	case	_	_
42	Erk2	erk2	NN	NN	_	40	nmod	_	_
43	activation	activation	NN	NN	_	42	dep	_	_
44	and	and	CC	CC	_	42	cc	_	_
45	transcription	transcription	NN	NN	_	42	conj	_	_
46	from	from	IN	IN	_	57	case	_	_
47	an	a	DT	DT	_	57	det	_	_
48	NFAT	nfat	NN	NN	_	57	compound	_	_
49	(	(	-LRB-	-LRB-	_	57	punct	_	_
50	nuclear	nuclear	JJ	JJ	_	57	amod	_	_
51	factor	factor	NN	NN	_	57	compound	_	_
52	of	of	IN	IN	_	57	amod	_	_
53	activated	activate	VBN	VBN	_	57	amod	_	_
54	T	t	NN	NN	_	57	compound	_	_
55	cells	cell	NNS	NNS	_	57	compound	_	_
56	)	)	-RRB-	-RRB-	_	57	punct	_	_
57	element	element	NN	NN	_	42	nmod	_	_
58	taken	take	VBN	VBN	_	57	acl	_	_
59	from	from	IN	IN	_	62	case	_	_
60	the	the	DT	DT	_	62	det	_	_
61	interleukin-2	interleukin-2	NN	NN	_	62	compound	_	_
62	promoter	promoter	NN	NN	_	58	nmod	_	_
63	.	.	.	.	_	3	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	TcR	tcr	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	activation	activation	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Erk2	erk2	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	inhibited	inhibit	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	18	case	_	_
12	a	a	DT	DT	_	18	det	_	_
13	previously	previously	RB	RB	_	14	advmod	_	_
14	described	describe	VBN	VBN	_	18	amod	_	_
15	truncated	truncated	JJ	JJ	_	18	amod	_	_
16	form	form	NN	NN	_	18	compound	_	_
17	of	of	IN	IN	_	18	amod	_	_
18	p85	p85	NN	NN	_	10	nmod	_	_
19	that	that	WDT	WDT	_	22	nsubj	_	_
20	can	can	MD	MD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	bind	bind	VB	VB	_	18	acl:relcl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	catalytic	catalytic	JJ	JJ	_	25	amod	_	_
25	subunit	subunit	NN	NN	_	22	dobj	_	_
26	,	,	,	,	_	18	punct	_	_
27	but	but	CC	CC	_	18	cc	_	_
28	not	not	RB	RB	_	31	neg	_	_
29	by	by	IN	IN	_	31	case	_	_
30	other	other	JJ	JJ	_	31	amod	_	_
31	constructs	construct	NNS	NNS	_	18	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	p85	p85	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	several	several	JJ	JJ	_	7	amod	_	_
5	mutant	mutant	JJ	JJ	_	7	amod	_	_
6	p85	p85	NN	NN	_	7	compound	_	_
7	alleles	allele	NNS	NNS	_	8	nsubj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	dramatic	dramatic	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	NFAT	nfat	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Most	most	RBS	RBS	_	2	advmod	_	_
2	interestingly	interestingly	RB	RB	_	8	advmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	N-terminal	n-terminal	JJ	JJ	_	7	amod	_	_
6	SH2	sh2	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	8	nsubj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	,	,	,	,	_	8	punct	_	_
13	whereas	whereas	IN	IN	_	23	mark	_	_
14	a	a	DT	DT	_	16	det	_	_
15	mutant	mutant	JJ	JJ	_	16	amod	_	_
16	p85	p85	NN	NN	_	23	nsubj	_	_
17	containing	contain	VBG	VBG	_	16	acl	_	_
18	only	only	RB	RB	_	22	advmod	_	_
19	the	the	DT	DT	_	22	det	_	_
20	two	two	CD	CD	_	22	nummod	_	_
21	SH2	sh2	NN	NN	_	22	compound	_	_
22	domains	domain	NNS	NNS	_	17	dobj	_	_
23	enhanced	enhance	VBD	VBD	_	8	advcl	_	_
24	basal	basal	JJ	JJ	_	26	amod	_	_
25	NFAT	nfat	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	Ras-dependent	ras-dependent	JJ	JJ	_	30	amod	_	_
30	manner	manner	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	Ionomycin	ionomycin	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	synergistic	synergistic	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NFAT	nfat	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	expressing	express	VBG	VBG	_	8	acl	_	_
10	p85	p85	NN	NN	_	11	compound	_	_
11	mutants	mutant	NNS	NNS	_	9	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	contained	contain	VBD	VBD	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	C-terminal	c-terminal	JJ	JJ	_	17	amod	_	_
16	SH2	sh2	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	phosphotyrosine-containing	phosphotyrosine-containing	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	bound	bind	VBN	VBN	_	4	acl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	truncated	truncate	VBN	VBN	_	9	amod	_	_
8	p85	p85	NN	NN	_	9	compound	_	_
9	constructs	construct	NNS	NNS	_	5	nmod	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	cooperative	cooperative	JJ	JJ	_	12	amod	_	_
12	binding	binding	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	SH2	sh2	NN	NN	_	17	compound	_	_
17	domains	domain	NNS	NNS	_	12	nmod	_	_
18	but	but	CC	CC	_	12	cc	_	_
19	no	no	DT	DT	_	21	neg	_	_
20	apparent	apparent	JJ	JJ	_	21	amod	_	_
21	differences	difference	NNS	NNS	_	12	conj	_	_
22	between	between	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	N-	n-	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	C-terminal	c-terminal	JJ	JJ	_	24	conj	_	_
27	SH2	sh2	NN	NN	_	28	compound	_	_
28	domains	domain	NNS	NNS	_	24	dep	_	_
29	.	.	.	.	_	10	punct	_	_

1	Wortmannin	wortmannin	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	interfere	interfere	VB	VB	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	NFAT	nfat	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	although	although	IN	IN	_	11	mark	_	_
10	it	it	PRP	PRP	_	11	nsubj	_	_
11	inhibited	inhibit	VBD	VBD	_	4	advcl	_	_
12	PI3-K	pi3-k	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Erk2	erk2	NN	NN	_	12	conj	_	_
15	activation	activation	NN	NN	_	12	dep	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	same	same	JJ	JJ	_	19	amod	_	_
19	experiment	experiment	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PI3-K	pi3-k	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	NFAT	nfat	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	through	through	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	complex	complex	JJ	JJ	_	15	amod	_	_
14	adaptor	adaptor	NN	NN	_	15	compound	_	_
15	function	function	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	subunit	subunit	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	that	that	IN	IN	_	27	mark	_	_
22	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
23	lipid	lipid	NN	NN	_	24	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	dispensable	dispensable	JJ	JJ	_	7	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	this	this	DT	DT	_	30	det	_	_
30	effect	effect	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	5	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	inducible	inducible	JJ	JJ	_	1	conj	_	_
4	protein/DNA	protein/dna	NN	NN	_	5	compound	_	_
5	interactions	interaction	NNS	NNS	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	interferon-gamma	interferon-gamma	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	5	advmod	_	_
12	in	in	NN	NN	_	16	dep	_	_
13	-LSB-	-lsb-	-LRB-	-LRB-	_	14	punct	_	_
14	corrected	correct	VBN	VBN	_	16	dep	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	14	punct	_	_
16	CD45RA	cd45ra	NN	NN	_	5	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CD45R0	cd45r0	NN	NN	_	16	conj	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	helper	helper	NN	NN	_	21	compound	_	_
21	subsets	subset	NNS	NNS	_	16	dep	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	25	punct	_	_
23	published	publish	VBN	VBN	_	24	amod	_	_
24	erratum	erratum	NN	NN	_	25	nsubj	_	_
25	appears	appear	VBZ	VBZ	_	5	dep	_	_
26	in	in	IN	IN	_	29	case	_	_
27	Eur	Eur	NNP	NNP	_	29	compound	_	_
28	J	J	NNP	NNP	_	29	compound	_	_
29	Immunol	Immunol	NNP	NNP	_	25	nmod	_	_
30	1997	1997	CD	CD	_	31	nummod	_	_
31	Jul	Jul	NNP	NNP	_	29	dep	_	_
32	;	;	:	:	_	29	punct	_	_
33	27	27	CD	CD	_	35	nummod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	7	7	CD	CD	_	29	dep	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	:	:	:	:	_	29	punct	_	_
38	1830	1830	CD	CD	_	29	dep	_	_
39	-RSB-	-rsb-	-RRB-	-RRB-	_	25	punct	_	_

1	Interferon-gamma	interferon-gamma	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-gamma	ifn-gamma	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	key	key	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	major	major	JJ	JJ	_	15	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	8	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	system	system	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	compare	compare	VB	VB	_	2	conj	_	_
5	protein/DNA	protein/dna	NN	NN	_	6	compound	_	_
6	interactions	interaction	NNS	NNS	_	2	dobj	_	_
7	at	at	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	native	native	JJ	JJ	_	11	amod	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	11	compound	_	_
11	locus	locus	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	analyzed	analyze	VBD	VBD	_	2	parataxis	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	dobj	_	_
22	by	by	IN	IN	_	30	case	_	_
23	ligation-mediated	ligation-mediated	JJ	JJ	_	26	amod	_	_
24	polymerase	polymerase	NN	NN	_	26	compound	_	_
25	chain	chain	NN	NN	_	26	compound	_	_
26	reaction	reaction	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	LM-PCR	lm-pcr	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	techniques	technique	NNS	NNS	_	17	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	Accordingly	accordingly	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	Jurkat	jurkat	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	23	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	primary	primary	JJ	JJ	_	8	amod	_	_
8	CD45RA	cd45ra	NN	NN	_	5	conj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CD45R0	cd45r0	NN	NN	_	8	conj	_	_
11	CD4+	cd4+	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	subsets	subset	NNS	NNS	_	8	dep	_	_
15	isolated	isolate	VBN	VBN	_	5	acl	_	_
16	from	from	IN	IN	_	18	case	_	_
17	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
18	blood	blood	NN	NN	_	15	nmod	_	_
19	using	use	VBG	VBG	_	15	xcomp	_	_
20	immunomagnetic	immunomagnetic	JJ	JJ	_	21	amod	_	_
21	beads	bead	NNS	NNS	_	19	dobj	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	cultured	culture	VBN	VBN	_	0	root	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	analyzed	analyze	VBN	VBN	_	23	conj	_	_
26	by	by	IN	IN	_	27	case	_	_
27	LM-PCR	lm-pcr	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	5	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	inducible	inducible	JJ	JJ	_	1	conj	_	_
4	protein/DNA	protein/dna	NN	NN	_	5	compound	_	_
5	interactions	interaction	NNS	NNS	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vivo	vivo	FW	FW	_	5	advmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	detected	detect	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	all	all	DT	DT	_	17	det	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	tested	test	VBN	VBN	_	17	acl	_	_
19	.	.	.	.	_	13	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	footprint	footprint	NN	NN	_	12	nsubjpass	_	_
6	between	between	IN	IN	_	7	case	_	_
7	-183	-183	CD	CD	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	-196	-196	CD	CD	_	7	conj	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	consistently	consistently	RB	RB	_	12	advmod	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CD45RA	cd45ra	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CD45R0	cd45r0	NN	NN	_	18	conj	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	helper	helper	NN	NN	_	23	compound	_	_
23	subsets	subset	NNS	NNS	_	18	dep	_	_
24	upon	upon	IN	IN	_	25	case	_	_
25	stimulation	stimulation	NN	NN	_	12	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	12-myristate	12-myristate	NN	NN	_	29	compound	_	_
29	13-acetate+phytohemagglutinin	13-acetate+phytohemagglutinin	NN	NN	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PMA+PHA	pma+pha	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	that	that	WDT	WDT	_	36	nsubj	_	_
34	was	be	VBD	VBD	_	36	cop	_	_
35	highly	highly	RB	RB	_	36	advmod	_	_
36	sensitive	sensitive	JJ	JJ	_	29	acl:relcl	_	_
37	to	to	TO	TO	_	38	case	_	_
38	treatment	treatment	NN	NN	_	36	nmod	_	_
39	with	with	IN	IN	_	40	case	_	_
40	corticosteroids	corticosteroid	NNS	NNS	_	38	nmod	_	_
41	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	target	target	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	11	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	denoted	denote	VBN	VBN	_	4	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	C-site	c-site	NN	NN	_	6	xcomp	_	_
9	,	,	,	,	_	4	punct	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	several	several	JJ	JJ	_	14	amod	_	_
14	criteria	criterion	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	19	case	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	distribution	distribution	NN	NN	_	19	compound	_	_
19	studies	study	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	stimulation	stimulation	NN	NN	_	22	compound	_	_
22	experiments	experiment	NNS	NNS	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	supershift	supershift	NN	NN	_	25	compound	_	_
25	assays	assay	NNS	NNS	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	cross-competition	cross-competition	JJ	JJ	_	32	amod	_	_
29	electrophoretic	electrophoretic	JJ	JJ	_	32	amod	_	_
30	mobility	mobility	NN	NN	_	32	compound	_	_
31	shift	shift	NN	NN	_	32	compound	_	_
32	assays	assay	NNS	NNS	_	19	conj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	bind	bind	VB	VB	_	11	xcomp	_	_
35	the	the	DT	DT	_	38	det	_	_
36	transcription	transcription	NN	NN	_	38	compound	_	_
37	factor	factor	NN	NN	_	38	compound	_	_
38	AP-1	ap-1	NN	NN	_	34	dobj	_	_
39	.	.	.	.	_	11	punct	_	_

1	Mutation	mutation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	C-site	c-site	NN	NN	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	prevented	prevent	VBD	VBD	_	1	acl:relcl	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	site	site	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	0	root	_	_
14	strikingly	strikingly	RB	RB	_	16	advmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	reduce	reduce	VB	VB	_	13	xcomp	_	_
17	inducible	inducible	JJ	JJ	_	19	amod	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	24	case	_	_
21	primary	primary	JJ	JJ	_	24	amod	_	_
22	CD45R0	cd45r0	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	16	nsubjpass	_	_
11	in	in	IN	IN	_	14	case	_	_
12	primary	primary	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	6	ccomp	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vivo	vivo	FW	FW	_	16	advmod	_	_
19	at	at	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	level	level	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	constitutive	constitutive	JJ	JJ	_	27	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inducible	inducible	JJ	JJ	_	23	conj	_	_
26	protein/DNA	protein/dna	NN	NN	_	27	compound	_	_
27	interactions	interaction	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	where	where	WRB	WRB	_	9	advmod	_	_
6	basal	basal	JJ	JJ	_	7	amod	_	_
7	transcription	transcription	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	maintained	maintain	VBN	VBN	_	4	acl:relcl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	binding	binding	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	various	various	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	11	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	whereas	whereas	IN	IN	_	30	mark	_	_
22	PMA+PHA-inducible	pma+pha-inducible	JJ	JJ	_	24	amod	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	24	compound	_	_
24	transcription	transcription	NN	NN	_	30	nsubjpass	_	_
25	in	in	IN	IN	_	28	case	_	_
26	CD45R0	cd45r0	NN	NN	_	28	compound	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	associated	associate	VBN	VBN	_	9	advcl	_	_
31	with	with	IN	IN	_	32	case	_	_
32	binding	binding	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	AP-1	ap-1	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	C-site	c-site	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Tap	tap	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	1	dep	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	interacts	interact	VBZ	VBZ	_	6	acl:relcl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	tip	tip	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	herpesvirus	herpesvirus	NN	NN	_	13	compound	_	_
13	saimiri	saimiri	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	induces	induce	VBZ	VBZ	_	8	conj	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	aggregation	aggregation	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	1	punct	_	_

1	Tip	tip	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	herpesvirus	herpesvirus	NN	NN	_	4	compound	_	_
4	saimiri	saimiri	NN	NN	_	1	nmod	_	_
5	associates	associate	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	Lck	lck	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	down-regulates	down-regulate	VBZ	VBZ	_	5	conj	_	_
10	Lck-mediated	lck-mediated	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	novel	novel	JJ	JJ	_	7	amod	_	_
5	cellular	cellular	JJ	JJ	_	4	dep	_	_
6	Tip-associated	tip-associated	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	2	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	Tap	tap	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	by	by	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	yeast	yeast	NN	NN	_	15	compound	_	_
14	two-hybrid	two-hybrid	JJ	JJ	_	15	amod	_	_
15	screen	screen	NN	NN	_	2	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Tap	tap	NN	NN	_	2	nsubj	_	_
2	associated	associate	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	Tip	tip	NN	NN	_	2	nmod	_	_
5	following	follow	VBG	VBG	_	7	case	_	_
6	transient	transient	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	COS-1	cos-1	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	stable	stable	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	7	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	Jurkat-T	jurkat-t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Tip	tip	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Tap	tap	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat-T	jurkat-t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	induced	induce	VBD	VBD	_	0	root	_	_
10	dramatic	dramatic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	aggregation	aggregation	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	9	punct	_	_

1	Aggregation	aggregation	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	likely	likely	RB	RB	_	4	advmod	_	_
4	caused	cause	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	up-regulated	up-regulate	VBN	VBN	_	9	amod	_	_
8	surface	surface	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	9	nmod	_	_
13	including	include	VBG	VBG	_	15	case	_	_
14	integrin	integrin	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	L-selectin	l-selectin	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	ICAM-3	icam-3	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	H-CAM	h-cam	NN	NN	_	15	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	aggregated	aggregated	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	had	have	VBD	VBD	_	0	root	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	40-fold	40-fold	RB	RB	_	12	nmod:npmod	_	_
12	higher	higher	JJR	JJR	_	13	amod	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	than	than	IN	IN	_	15	case	_	_
15	that	that	DT	DT	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	parental	parental	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Tap	tap	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	likely	likely	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	11	mark	_	_
7	be	be	VB	VB	_	11	cop	_	_
8	an	a	DT	DT	_	11	det	_	_
9	important	important	JJ	JJ	_	11	amod	_	_
10	cellular	cellular	JJ	JJ	_	9	dep	_	_
11	mediator	mediator	NN	NN	_	5	xcomp	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Tip	tip	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	transformation	transformation	NN	NN	_	11	nmod	_	_
19	by	by	IN	IN	_	21	case	_	_
20	herpesvirus	herpesvirus	NN	NN	_	21	compound	_	_
21	saimiri	saimiri	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Transactivation	transactivation	NN	NN	_	13	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	CIITA	ciita	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	the	the	DT	DT	_	11	det	_	_
6	type	type	NN	NN	_	11	compound	_	_
7	II	ii	CD	CD	_	11	nummod	_	_
8	bare	bare	JJ	JJ	_	11	amod	_	_
9	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
10	syndrome-associated	syndrome-associated	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	3	appos	_	_
12	,	,	,	,	_	1	punct	_	_
13	requires	require	VBZ	VBZ	_	0	root	_	_
14	participation	participation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	multiple	multiple	JJ	JJ	_	17	amod	_	_
17	regions	region	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	TATA	tata	NN	NN	_	23	compound	_	_
21	box	box	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	CIITA	ciita	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	positive	positive	JJ	JJ	_	5	amod	_	_
5	regulator	regulator	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	13	case	_	_
7	class	class	NN	NN	_	12	compound	_	_
8	II	ii	CD	CD	_	12	nummod	_	_
9	major	major	JJ	JJ	_	12	amod	_	_
10	histocompatibility	histocompatibility	NN	NN	_	12	compound	_	_
11	complex	complex	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	transcription	transcription	NN	NN	_	5	nmod	_	_
14	that	that	WDT	WDT	_	17	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	5	acl:relcl	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	cop	_	_
20	defective	defective	JJ	JJ	_	17	xcomp	_	_
21	in	in	IN	IN	_	22	case	_	_
22	one	one	CD	CD	_	20	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	five	five	CD	CD	_	27	nummod	_	_
26	complementation	complementation	NN	NN	_	27	compound	_	_
27	groups	group	NNS	NNS	_	22	nmod	_	_
28	of	of	IN	IN	_	35	case	_	_
29	class	class	NN	NN	_	35	compound	_	_
30	II	ii	CD	CD	_	35	nummod	_	_
31	major	major	JJ	JJ	_	35	amod	_	_
32	histocompatibility	histocompatibility	NN	NN	_	35	compound	_	_
33	complex-negative	complex-negative	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	27	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	N-terminal	n-terminal	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	capable	capable	JJ	JJ	_	0	root	_	_
6	of	of	IN	IN	_	7	mark	_	_
7	activating	activate	VBG	VBG	_	5	advcl	_	_
8	transcription	transcription	NN	NN	_	7	dobj	_	_
9	from	from	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	reporter	reporter	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	fused	fuse	VBN	VBN	_	7	advcl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	transactivation	transactivation	NN	NN	_	5	nmod	_	_
8	mediated	mediate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	CIITA	ciita	NN	NN	_	13	compound	_	_
12	activation	activation	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	8	nmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	studying	study	VBG	VBG	_	3	advcl	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	process	process	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	initiation	initiation	NN	NN	_	22	dep	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	elongation	elongation	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	Specifically	specifically	RB	RB	_	15	advmod	_	_
2	the	the	DT	DT	_	12	det	_	_
3	altered	altered	JJ	JJ	_	12	amod	_	_
4	specificity	specificity	NN	NN	_	12	compound	_	_
5	TBP	tbp	NN	NN	_	12	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	TATA	tata	NN	NN	_	10	compound	_	_
8	box	box	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	5	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	assay	assay	NN	NN	_	15	nsubjpass	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	used	use	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	analyze	analyze	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	response	response	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	CIITA	ciita	NN	NN	_	24	compound	_	_
23	activation	activation	NN	NN	_	24	compound	_	_
24	domain	domain	NN	NN	_	19	nmod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	mutations	mutation	NNS	NNS	_	19	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	TBP	tbp	NN	NN	_	26	nmod	_	_
29	known	know	VBN	VBN	_	26	acl	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	disrupt	disrupt	VB	VB	_	29	xcomp	_	_
32	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
33	interaction	interaction	NN	NN	_	31	dobj	_	_
34	with	with	IN	IN	_	38	case	_	_
35	its	its	PRP$	PRP$	_	38	nmod:poss	_	_
36	associated	associate	VBN	VBN	_	38	amod	_	_
37	general	general	JJ	JJ	_	38	amod	_	_
38	factors	factor	NNS	NNS	_	33	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	Transactivation	transactivation	NN	NN	_	6	nsubj	_	_
2	by	by	IN	IN	_	3	case	_	_
3	CIITA	ciita	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	extremely	extremely	RB	RB	_	6	advmod	_	_
6	sensitive	sensitive	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	mutation	mutation	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	TBP	tbp	NN	NN	_	9	nmod	_	_
12	that	that	WDT	WDT	_	16	nsubjpass	_	_
13	in	in	IN	IN	_	14	case	_	_
14	yeast	yeast	NN	NN	_	16	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	known	know	VBN	VBN	_	9	acl:relcl	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	abolish	abolish	VB	VB	_	16	xcomp	_	_
19	VP16-mediated	vp16-mediated	JJ	JJ	_	20	amod	_	_
20	transcription	transcription	NN	NN	_	18	dobj	_	_
21	but	but	CC	CC	_	18	cc	_	_
22	leaves	leave	VBZ	VBZ	_	18	conj	_	_
23	basal	basal	JJ	JJ	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	25	nsubj	_	_
25	unaffected	unaffected	JJ	JJ	_	22	xcomp	_	_
26	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	TBP	tbp	NN	NN	_	3	compound	_	_
3	mutant	mutant	NN	NN	_	12	nsubj	_	_
4	defective	defective	JJ	JJ	_	3	amod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	interaction	interaction	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	TBP-associated	tbp-associated	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	6	nmod	_	_
10	TAFII250	tafii250	NN	NN	_	9	dep	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	failed	fail	VBD	VBD	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	mediate	mediate	VB	VB	_	12	xcomp	_	_
15	transactivation	transactivation	NN	NN	_	14	dobj	_	_
16	through	through	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	CIITA	ciita	NN	NN	_	20	compound	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Certain	certain	JJ	JJ	_	2	amod	_	_
2	interactions	interaction	NNS	NNS	_	18	nsubjpass	_	_
3	between	between	IN	IN	_	4	case	_	_
4	TBP	tbp	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	general	general	JJ	JJ	_	7	amod	_	_
7	factors	factor	NNS	NNS	_	4	conj	_	_
8	that	that	WDT	WDT	_	11	nsubjpass	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	specifically	specifically	RB	RB	_	11	advmod	_	_
11	required	require	VBN	VBN	_	7	acl:relcl	_	_
12	for	for	IN	IN	_	15	case	_	_
13	acidic	acidic	JJ	JJ	_	15	amod	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	domains	domain	NNS	NNS	_	11	nmod	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	required	require	VBN	VBN	_	0	root	_	_
19	for	for	IN	IN	_	21	case	_	_
20	CIITA-mediated	ciita-mediated	JJ	JJ	_	21	amod	_	_
21	transactivation	transactivation	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	reach	reach	VB	VB	_	18	xcomp	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	full	full	JJ	JJ	_	26	amod	_	_
26	potential	potential	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	18	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	like	like	IN	IN	_	4	case	_	_
4	VP16	vp16	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	CIITA	ciita	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	able	able	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	stimulate	stimulate	VB	VB	_	8	xcomp	_	_
11	elongation	elongation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	transcription	transcription	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Overall	overall	RB	RB	_	13	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	mechanism	mechanism	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	transactivation	transactivation	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	B-cell-specific	b-cell-specific	JJ	JJ	_	10	amod	_	_
10	CIITA	ciita	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	similar	similar	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	that	that	DT	DT	_	13	nmod	_	_
16	mediated	mediate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	herpes	herpes	NN	NN	_	21	compound	_	_
20	virus	virus	NN	NN	_	21	compound	_	_
21	transactivator	transactivator	NN	NN	_	16	nmod	_	_
22	VP16	vp16	NN	NN	_	21	dep	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ways	way	NNS	NNS	_	13	nmod	_	_
26	that	that	WDT	WDT	_	29	nsubjpass	_	_
27	have	have	VBP	VBP	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	tested	test	VBN	VBN	_	25	acl:relcl	_	_
30	.	.	.	.	_	13	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	species	species	NNS	NNS	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	antioxidants	antioxidant	NNS	NNS	_	3	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	inflammatory	inflammatory	JJ	JJ	_	8	amod	_	_
8	diseases	disease	NNS	NNS	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	aims	aim	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	review	review	VB	VB	_	3	xcomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	free	free	JJ	JJ	_	10	amod	_	_
10	radical-induced	radical-induced	JJ	JJ	_	12	amod	_	_
11	tissue	tissue	NN	NN	_	12	compound	_	_
12	damage	damage	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	antioxidant	antioxidant	JJ	JJ	_	16	amod	_	_
15	defence	defence	NN	NN	_	16	compound	_	_
16	mechanisms	mechanism	NNS	NNS	_	7	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	inflammatory	inflammatory	JJ	JJ	_	19	amod	_	_
19	diseases	disease	NNS	NNS	_	7	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	involve	involve	VBP	VBP	_	19	acl:relcl	_	_
22	pathogenic	pathogenic	JJ	JJ	_	23	amod	_	_
23	processes	process	NNS	NNS	_	21	dobj	_	_
24	similar	similar	JJ	JJ	_	23	amod	_	_
25	to	to	TO	TO	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	periodontal	periodontal	JJ	JJ	_	28	amod	_	_
28	diseases	disease	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	8	det	_	_
4	clearly	clearly	RB	RB	_	5	advmod	_	_
5	defined	define	VBN	VBN	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	substantial	substantial	JJ	JJ	_	5	conj	_	_
8	role	role	NN	NN	_	2	nsubj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	free	free	JJ	JJ	_	11	amod	_	_
11	radicals	radical	NNS	NNS	_	8	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	reactive	reactive	JJ	JJ	_	15	amod	_	_
14	oxygen	oxygen	NN	NN	_	15	compound	_	_
15	species	species	NNS	NNS	_	11	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	ROS	ro	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	periodontitis	periodontitis	NN	NN	_	8	nmod	_	_
21	,	,	,	,	_	2	punct	_	_
22	but	but	CC	CC	_	2	cc	_	_
23	little	little	JJ	JJ	_	24	amod	_	_
24	research	research	NN	NN	_	27	nsubjpass	_	_
25	has	have	VBZ	VBZ	_	27	aux	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	performed	perform	VBN	VBN	_	2	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	this	this	DT	DT	_	30	det	_	_
30	area	area	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	reviews	review	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	considerable	considerable	JJ	JJ	_	6	amod	_	_
6	data	datum	NNS	NNS	_	3	dobj	_	_
7	available	available	JJ	JJ	_	6	amod	_	_
8	relating	relate	VBG	VBG	_	6	acl	_	_
9	ROS	ro	NNS	NNS	_	10	compound	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	antioxidant	antioxidant	JJ	JJ	_	13	amod	_	_
13	defence	defence	NN	NN	_	10	conj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	diseases	disease	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	attempts	attempt	VBZ	VBZ	_	3	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	draw	draw	VB	VB	_	18	xcomp	_	_
21	parallels	parallel	NNS	NNS	_	20	dobj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	periodontitis	periodontitis	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	in	in	IN	IN	_	27	case	_	_
26	an	a	DT	DT	_	27	det	_	_
27	effort	effort	NN	NN	_	18	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	stimulate	stimulate	VB	VB	_	27	acl	_	_
30	more	more	RBR	RBR	_	31	advmod	_	_
31	periodontal	periodontal	JJ	JJ	_	32	amod	_	_
32	research	research	NN	NN	_	29	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	this	this	DT	DT	_	36	det	_	_
35	important	important	JJ	JJ	_	36	amod	_	_
36	area	area	NN	NN	_	29	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	discovery	discovery	NN	NN	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	transcription	transcription	NN	NN	_	11	compound	_	_
7	factor	factor	NN	NN	_	11	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
9	factor	factor	NN	NN	_	11	compound	_	_
10	kappa	kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	reviewed	review	VBN	VBN	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	several	several	JJ	JJ	_	20	amod	_	_
20	potential	potential	JJ	JJ	_	21	amod	_	_
21	pathways	pathway	NNS	NNS	_	33	nsubjpass	_	_
22	for	for	IN	IN	_	26	case	_	_
23	cytokine-induced	cytokine-induced	JJ	JJ	_	26	amod	_	_
24	periodontal	periodontal	JJ	JJ	_	23	dep	_	_
25	tissue	tissue	NN	NN	_	26	compound	_	_
26	damage	damage	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	21	punct	_	_
28	mediated	mediate	VBN	VBN	_	21	acl	_	_
29	by	by	IN	IN	_	31	case	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B1	b1	NN	NN	_	28	nmod	_	_
32	are	be	VBP	VBP	_	33	auxpass	_	_
33	discussed	discuss	VBN	VBN	_	17	conj	_	_
34	.	.	.	.	_	17	punct	_	_

1	Emphasis	emphasis	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	placed	place	VBN	VBN	_	0	root	_	_
4	on	on	IN	IN	_	5	case	_	_
5	cytokines	cytokine	NNS	NNS	_	3	nmod	_	_
6	that	that	WDT	WDT	_	9	nsubjpass	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	studied	study	VBN	VBN	_	5	acl:relcl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	periodontitis	periodontitis	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	principally	principally	RB	RB	_	14	advmod	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	5	appos	_	_
15	,	,	,	,	_	14	punct	_	_
16	IL-1	il-1	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	IL-6	il-6	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	IL-8	il-8	NN	NN	_	14	conj	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	beta-interferon	beta-interferon	NN	NN	_	14	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	link	link	NN	NN	_	29	nsubjpass	_	_
3	between	between	IN	IN	_	5	case	_	_
4	cellular	cellular	JJ	JJ	_	5	amod	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	such	such	JJ	JJ	_	8	amod	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	mediators	mediator	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	inflammation	inflammation	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	the	the	DT	DT	_	18	dep	_	_
14	antioxidant	antioxidant	JJ	JJ	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	AO	ao	JJ	JJ	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	thiols	thiol	NNS	NNS	_	5	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	cysteine	cysteine	NN	NN	_	18	conj	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	reduced	reduce	VBN	VBN	_	23	amod	_	_
23	glutathione	glutathione	NN	NN	_	18	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	GSH	gsh	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	29	punct	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	discussed	discuss	VBN	VBN	_	0	root	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	it	it	PRP	PRP	_	33	nsubjpass	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	hypothesised	hypothesise	VBN	VBN	_	29	conj	_	_
34	that	that	IN	IN	_	39	mark	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	antagonists	antagonist	NNS	NNS	_	39	nsubj	_	_
38	may	may	MD	MD	_	39	aux	_	_
39	offer	offer	VB	VB	_	33	ccomp	_	_
40	important	important	JJ	JJ	_	42	amod	_	_
41	therapeutic	therapeutic	JJ	JJ	_	40	dep	_	_
42	benefits	benefit	NNS	NNS	_	39	dobj	_	_
43	.	.	.	.	_	29	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HSF2-beta	hsf2-beta	NN	NN	_	1	nmod	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	hemin-induced	hemin-induced	JJ	JJ	_	9	amod	_	_
6	heat	heat	NN	NN	_	9	compound	_	_
7	shock	shock	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	9	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	K562	k562	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Acquisition	acquisition	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	12	case	_	_
3	heat	heat	NN	NN	_	5	compound	_	_
4	shock	shock	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	12	compound	_	_
6	2	2	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HSF2	hsf2	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	1	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	accompanied	accompany	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	induced	induce	VBN	VBN	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	heat	heat	NN	NN	_	21	compound	_	_
20	shock	shock	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	hemin-treated	hemin-treated	JJ	JJ	_	25	amod	_	_
24	K562	k562	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	17	nmod	_	_
26	undergoing	undergo	VBG	VBG	_	25	acl	_	_
27	erythroid	erythroid	JJ	JJ	_	28	amod	_	_
28	differentiation	differentiation	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	14	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	HSF2	hsf2	NN	NN	_	6	nsubj	_	_
6	consists	consist	VBZ	VBZ	_	3	ccomp	_	_
7	of	of	IN	IN	_	11	case	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	alternatively	alternatively	RB	RB	_	10	advmod	_	_
10	spliced	splice	VBN	VBN	_	11	amod	_	_
11	isoforms	isoform	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	HSF2-alpha	hsf2-alpha	NN	NN	_	11	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HSF2-beta	hsf2-beta	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	whose	whose	WP$	WP$	_	19	nmod:poss	_	_
18	relative	relative	JJ	JJ	_	19	amod	_	_
19	abundance	abundance	NN	NN	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	developmentally	developmentally	RB	RB	_	22	advmod	_	_
22	regulated	regulate	VBN	VBN	_	11	acl:relcl	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	varies	vary	VBZ	VBZ	_	22	conj	_	_
25	between	between	IN	IN	_	27	case	_	_
26	different	different	JJ	JJ	_	27	amod	_	_
27	tissues	tissue	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	whether	whether	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molar	molar	JJ	JJ	_	6	amod	_	_
6	ratio	ratio	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	HSF2-alpha	hsf2-alpha	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	HSF2-beta	hsf2-beta	NN	NN	_	8	conj	_	_
11	isoforms	isoform	NNS	NNS	_	8	dep	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	crucial	crucial	JJ	JJ	_	2	ccomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HSF2	hsf2	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	whether	whether	IN	IN	_	24	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HSF2	hsf2	NN	NN	_	23	compound	_	_
23	isoforms	isoform	NNS	NNS	_	24	nsubj	_	_
24	play	play	VBP	VBP	_	13	conj	_	_
25	functionally	functionally	RB	RB	_	26	advmod	_	_
26	distinct	distinct	JJ	JJ	_	27	amod	_	_
27	roles	role	NNS	NNS	_	24	dobj	_	_
28	during	during	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	hemin-mediated	hemin-mediated	JJ	JJ	_	31	amod	_	_
31	erythroid	erythroid	JJ	JJ	_	32	amod	_	_
32	differentiation	differentiation	NN	NN	_	24	nmod	_	_
33	,	,	,	,	_	2	punct	_	_
34	we	we	PRP	PRP	_	35	nsubj	_	_
35	generated	generate	VBD	VBD	_	2	parataxis	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	clones	clone	NNS	NNS	_	35	dobj	_	_
38	expressing	express	VBG	VBG	_	37	acl	_	_
39	different	different	JJ	JJ	_	40	amod	_	_
40	levels	level	NNS	NNS	_	38	dobj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	HSF2-alpha	hsf2-alpha	NN	NN	_	40	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	HSF2-beta	hsf2-beta	NN	NN	_	42	conj	_	_
45	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	in	in	IN	IN	_	7	case	_	_
5	parental	parental	JJ	JJ	_	7	amod	_	_
6	K562	k562	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	14	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HSF2-alpha	hsf2-alpha	NN	NN	_	11	compound	_	_
11	isoform	isoform	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	predominantly	predominantly	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	2	ccomp	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	HSF2	hsf2	NN	NN	_	19	nsubjpass	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	activated	activate	VBN	VBN	_	14	conj	_	_
20	upon	upon	IN	IN	_	22	case	_	_
21	hemin	hemin	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	28	nmod	_	_
3	,	,	,	,	_	28	punct	_	_
4	when	when	WRB	WRB	_	7	advmod	_	_
5	HSF2-beta	hsf2-beta	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	expressed	express	VBN	VBN	_	28	advcl	_	_
8	at	at	IN	IN	_	9	case	_	_
9	levels	level	NNS	NNS	_	7	nmod	_	_
10	exceeding	exceed	VBG	VBG	_	9	acl	_	_
11	those	those	DT	DT	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	endogenous	endogenous	JJ	JJ	_	14	amod	_	_
14	HSF2-alpha	hsf2-alpha	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	28	punct	_	_
16	the	the	DT	DT	_	20	dep	_	_
17	hemin-induced	hemin-induced	JJ	JJ	_	20	amod	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	28	nsubjpass	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	transcription	transcription	NN	NN	_	20	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	heat	heat	NN	NN	_	26	compound	_	_
25	shock	shock	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	are	be	VBP	VBP	_	28	auxpass	_	_
28	repressed	repress	VBN	VBN	_	0	root	_	_
29	,	,	,	,	_	28	punct	_	_
30	whereas	whereas	IN	IN	_	34	mark	_	_
31	overexpression	overexpression	NN	NN	_	34	nsubj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	HSF2-alpha	hsf2-alpha	NN	NN	_	31	nmod	_	_
34	results	result	VBZ	VBZ	_	28	advcl	_	_
35	in	in	IN	IN	_	39	case	_	_
36	an	a	DT	DT	_	39	det	_	_
37	enhanced	enhance	VBN	VBN	_	39	amod	_	_
38	hemin	hemin	NN	NN	_	39	compound	_	_
39	response	response	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	28	punct	_	_

1	Furthermore	furthermore	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	hemin-induced	hemin-induced	JJ	JJ	_	5	amod	_	_
5	accumulation	accumulation	NN	NN	_	18	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	globin	globin	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	known	know	VBN	VBN	_	7	acl	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	marker	marker	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	decreased	decrease	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	18	nmod	_	_
21	overexpressing	overexpress	VBG	VBG	_	20	acl	_	_
22	HSF2-beta	hsf2-beta	NN	NN	_	21	dobj	_	_
23	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	suggest	suggest	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	HSF2-beta	hsf2-beta	NN	NN	_	5	nsubj	_	_
5	acts	act	VBZ	VBZ	_	2	ccomp	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	negative	negative	JJ	JJ	_	9	amod	_	_
9	regulator	regulator	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HSF2	hsf2	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	during	during	IN	IN	_	16	case	_	_
14	hemin-mediated	hemin-mediated	JJ	JJ	_	15	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	5	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	K562	k562	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	2	amod	_	_
2	repression	repression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cytokine	cytokine	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	arteritis-SCID	arteritis-scid	NN	NN	_	10	compound	_	_
10	chimeras	chimera	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Giant	giant	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	arteritis	arteritis	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GCA	gca	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	vasculitic	vasculitic	JJ	JJ	_	10	amod	_	_
10	syndrome	syndrome	NN	NN	_	0	root	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	preferentially	preferentially	RB	RB	_	13	advmod	_	_
13	affects	affect	VBZ	VBZ	_	10	acl:relcl	_	_
14	medium	medium	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	large-sized	large-sized	JJ	JJ	_	14	conj	_	_
17	arteries	artery	NNS	NNS	_	14	dep	_	_
18	.	.	.	.	_	10	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	therapy	therapy	NN	NN	_	3	nsubj	_	_
3	resolves	resolve	VBZ	VBZ	_	0	root	_	_
4	clinical	clinical	JJ	JJ	_	5	amod	_	_
5	symptoms	symptom	NNS	NNS	_	3	dobj	_	_
6	within	within	IN	IN	_	7	case	_	_
7	hours	hour	NNS	NNS	_	3	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	days	day	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	but	but	CC	CC	_	3	cc	_	_
12	therapy	therapy	NN	NN	_	13	nsubj	_	_
13	has	have	VBZ	VBZ	_	3	conj	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	continued	continue	VBN	VBN	_	13	xcomp	_	_
17	over	over	IN	IN	_	19	case	_	_
18	several	several	JJ	JJ	_	19	amod	_	_
19	years	year	NNS	NNS	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	prevent	prevent	VB	VB	_	13	xcomp	_	_
22	disease	disease	NN	NN	_	23	compound	_	_
23	relapses	relapse	NNS	NNS	_	21	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	known	know	VBN	VBN	_	0	root	_	_
5	whether	whether	IN	IN	_	9	dep	_	_
6	and	and	CC	CC	_	9	cc	_	_
7	how	how	WRB	WRB	_	9	conj	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	9	nsubj	_	_
9	affect	affect	VBP	VBP	_	4	dep	_	_
10	the	the	DT	DT	_	11	det	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
15	infiltrate	infiltrate	NN	NN	_	11	nmod	_	_
16	or	or	CC	CC	_	9	cc	_	_
17	why	why	IN	IN	_	20	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	disease	disease	NN	NN	_	20	nsubj	_	_
20	persists	persist	VBZ	VBZ	_	9	conj	_	_
21	subclinically	subclinically	RB	RB	_	20	advmod	_	_
22	despite	despite	IN	IN	_	24	case	_	_
23	chronic	chronic	JJ	JJ	_	24	amod	_	_
24	treatment	treatment	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	GCA	gca	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	self-sustained	self-sustained	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	temporal	temporal	JJ	JJ	_	6	amod	_	_
6	arteries	artery	NNS	NNS	_	3	nmod	_	_
7	engrafted	engraft	VBN	VBN	_	6	acl	_	_
8	into	into	IN	IN	_	10	case	_	_
9	SCID	scid	NN	NN	_	10	compound	_	_
10	mice	mouse	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	providing	provide	VBG	VBG	_	3	xcomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	model	model	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	28	nmod	_	_
17	the	the	DT	DT	_	18	det	_	_
18	mechanisms	mechanism	NNS	NNS	_	28	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	action	action	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	18	cc	_	_
22	limitations	limitation	NNS	NNS	_	18	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	25	compound	_	_
25	therapy	therapy	NN	NN	_	22	nmod	_	_
26	can	can	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	examined	examine	VBN	VBN	_	14	acl:relcl	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vivo	vivo	FW	FW	_	28	advmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Administration	administration	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	temporal	temporal	JJ	JJ	_	7	amod	_	_
6	artery-SCID	artery-scid	NN	NN	_	7	compound	_	_
7	chimeras	chimera	NNS	NNS	_	1	nmod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	wk	wk	NN	NN	_	1	nmod	_	_
11	induced	induce	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	partial	partial	JJ	JJ	_	14	amod	_	_
14	suppression	suppression	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cell	cell	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	macrophage	macrophage	NN	NN	_	17	conj	_	_
20	function	function	NN	NN	_	17	dep	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	indicated	indicate	VBN	VBN	_	11	advcl	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	reduced	reduce	VBN	VBN	_	27	amod	_	_
26	tissue	tissue	NN	NN	_	27	compound	_	_
27	concentrations	concentration	NNS	NNS	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	IL-2	il-2	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	IL-1beta	il-1beta	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	IL-6	il-6	NN	NN	_	29	conj	_	_
35	mRNA	mrna	NN	NN	_	29	dep	_	_
36	,	,	,	,	_	27	punct	_	_
37	and	and	CC	CC	_	27	cc	_	_
38	by	by	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	diminished	diminish	VBN	VBN	_	41	amod	_	_
41	expression	expression	NN	NN	_	27	conj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	inducible	inducible	JJ	JJ	_	45	amod	_	_
44	NO	no	NN	NN	_	45	compound	_	_
45	synthase	synthase	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	synthesis	synthesis	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	11	auxpass	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	slightly	slightly	RB	RB	_	11	advmod	_	_
11	decreased	decrease	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	expression	expression	NN	NN	_	18	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TGF-beta1	tgf-beta1	NN	NN	_	14	nmod	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	unaffected	unaffected	JJ	JJ	_	11	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	correlated	correlate	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	activation	activation	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IkappaBalpha	ikappabalpha	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	blockade	blockade	NN	NN	_	5	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	translocation	translocation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NFkappaB	nfkappab	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	xenotransplanted	xenotransplant	VBN	VBN	_	21	amod	_	_
21	tissue	tissue	NN	NN	_	5	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Dose-response	dose-response	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	steroid	steroid	NN	NN	_	6	compound	_	_
6	doses	dose	NNS	NNS	_	13	nsubj	_	_
7	currently	currently	RB	RB	_	8	advmod	_	_
8	used	use	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	medicine	medicine	NN	NN	_	8	nmod	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	suboptimal	suboptimal	JJ	JJ	_	3	ccomp	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	repressing	repress	VBG	VBG	_	13	advcl	_	_
16	NFkappaB-mediated	nfkappab-mediated	JJ	JJ	_	18	amod	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	inflammatory	inflammatory	JJ	JJ	_	22	amod	_	_
22	lesions	lesion	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Chronic	chronic	JJ	JJ	_	3	amod	_	_
2	steroid	steroid	NN	NN	_	3	compound	_	_
3	therapy	therapy	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	deplete	deplete	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	products	product	NNS	NNS	_	7	dobj	_	_
12	IL-2	il-2	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	whereas	whereas	IN	IN	_	25	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activation	activation	NN	NN	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	21	case	_	_
20	tissue-infiltrating	tissue-infiltrating	JJ	JJ	_	21	amod	_	_
21	macrophages	macrophage	NNS	NNS	_	18	nmod	_	_
22	was	be	VBD	VBD	_	25	auxpass	_	_
23	only	only	RB	RB	_	24	advmod	_	_
24	partially	partially	RB	RB	_	25	advmod	_	_
25	affected	affect	VBN	VBN	_	5	advcl	_	_
26	.	.	.	.	_	5	punct	_	_

1	IL-1beta	il-1beta	NN	NN	_	2	compound	_	_
2	transcription	transcription	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	abrogated	abrogate	VBN	VBN	_	0	root	_	_
5	;	;	:	:	_	4	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	contrast	contrast	NN	NN	_	14	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	TGF-beta1	tgf-beta1	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	14	nsubj	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	steroid	steroid	NN	NN	_	14	nmod:npmod	_	_
14	resistant	resistant	JJ	JJ	_	4	parataxis	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	persistence	persistence	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	TGF-beta1-transcribing	tgf-beta1-transcribing	JJ	JJ	_	5	amod	_	_
5	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	2	punct	_	_
7	despite	despite	IN	IN	_	8	case	_	_
8	paralysis	paralysis	NN	NN	_	15	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	function	function	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	provide	provide	VB	VB	_	0	root	_	_
16	an	a	DT	DT	_	17	det	_	_
17	explanation	explanation	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	chronicity	chronicity	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	disease	disease	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	identify	identify	VB	VB	_	15	conj	_	_
28	a	a	DT	DT	_	31	det	_	_
29	novel	novel	JJ	JJ	_	31	amod	_	_
30	therapeutic	therapeutic	JJ	JJ	_	29	dep	_	_
31	target	target	NN	NN	_	27	dobj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	this	this	DT	DT	_	35	det	_	_
34	inflammatory	inflammatory	JJ	JJ	_	35	amod	_	_
35	vasculopathy	vasculopathy	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	IL-4	il-4	NN	NN	_	6	compound	_	_
3	receptor	receptor	NN	NN	_	6	compound	_	_
4	alpha-chain	alpha-chain	NN	NN	_	6	compound	_	_
5	cytoplasmic	cytoplasmic	JJ	JJ	_	6	amod	_	_
6	domain	domain	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	sufficient	sufficient	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	JAK-1	jak-1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	STAT6	stat6	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	10	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	IL-4-specific	il-4-specific	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	common	common	JJ	JJ	_	3	amod	_	_
3	gamma-chain	gamma-chain	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	gamma(c)	gamma(c)	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	IL-4R	il-4r	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	yet	yet	RB	RB	_	10	advmod	_	_
16	cells	cell	NNS	NNS	_	20	nsubj	_	_
17	lacking	lack	VBG	VBG	_	16	acl	_	_
18	gamma(c)	gamma(c)	NN	NN	_	17	dobj	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	able	able	JJ	JJ	_	10	parataxis	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	respond	respond	VB	VB	_	20	xcomp	_	_
23	to	to	TO	TO	_	24	case	_	_
24	IL-4	il-4	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	has	have	VBZ	VBZ	_	3	aux	_	_
3	led	lead	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	suggestion	suggestion	NN	NN	_	3	nmod	_	_
7	that	that	IN	IN	_	25	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	surrogate	surrogate	JJ	JJ	_	10	amod	_	_
10	gamma'-chain	gamma'-chain	NN	NN	_	25	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	interact	interact	VB	VB	_	10	acl:relcl	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	IL-4R	il-4r	NN	NN	_	19	compound	_	_
18	alpha	alpha	NN	NN	_	19	compound	_	_
19	chain	chain	NN	NN	_	14	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	mediate	mediate	VB	VB	_	14	xcomp	_	_
22	signaling	signaling	NN	NN	_	21	dobj	_	_
23	,	,	,	,	_	10	punct	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	expressed	express	VBN	VBN	_	6	ccomp	_	_
26	on	on	IN	IN	_	27	case	_	_
27	cells	cell	NNS	NNS	_	25	nmod	_	_
28	lacking	lack	VBG	VBG	_	27	acl	_	_
29	gamma(c)	gamma(c)	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	alternative	alternative	JJ	JJ	_	3	amod	_	_
3	possibility	possibility	NN	NN	_	4	nsubj	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	absence	absence	NN	NN	_	17	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	gamma(c)	gamma(c)	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	the	the	DT	DT	_	15	det	_	_
13	IL-4R	il-4r	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	chain	chain	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	able	able	JJ	JJ	_	4	ccomp	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	transduce	transduce	VB	VB	_	17	xcomp	_	_
20	signals	signal	NNS	NNS	_	19	dobj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	homodimerization	homodimerization	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	5	det	_	_
4	latter	latter	JJ	JJ	_	5	amod	_	_
5	possibility	possibility	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	2	punct	_	_
7	a	a	DT	DT	_	9	det	_	_
8	chimeric	chimeric	JJ	JJ	_	9	amod	_	_
9	receptor	receptor	NN	NN	_	38	nsubjpass	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	extracellular	extracellular	JJ	JJ	_	13	amod	_	_
13	domain	domain	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	c-kit	c-kit	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	24	punct	_	_
17	the	the	DT	DT	_	24	det	_	_
18	stem	stem	NN	NN	_	24	compound	_	_
19	cell	cell	NN	NN	_	24	compound	_	_
20	factor	factor	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	SCF	scf	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	receptor	receptor	NN	NN	_	15	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	the	the	DT	DT	_	28	dep	_	_
28	cytoplasmic	cytoplasmic	JJ	JJ	_	13	conj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	transmembrane	transmembrane	JJ	JJ	_	28	conj	_	_
31	domains	domain	NNS	NNS	_	28	dep	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	IL-4R	il-4r	NN	NN	_	36	compound	_	_
35	alpha	alpha	NN	NN	_	36	compound	_	_
36	chain	chain	NN	NN	_	28	nmod	_	_
37	was	be	VBD	VBD	_	38	auxpass	_	_
38	generated	generate	VBN	VBN	_	2	parataxis	_	_
39	.	.	.	.	_	2	punct	_	_

1	Treatment	treatment	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	expressing	express	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	chimeric	chimeric	JJ	JJ	_	7	amod	_	_
7	receptor	receptor	NN	NN	_	4	dobj	_	_
8	kit/IL-4R	kit/il-4r	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	7	dep	_	_
10	with	with	IN	IN	_	11	case	_	_
11	SCF	scf	NN	NN	_	1	nmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	activation	activation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	IL-4R	il-4r	NN	NN	_	18	compound	_	_
17	alpha-associated	alpha-associated	JJ	JJ	_	18	amod	_	_
18	kinase	kinase	NN	NN	_	13	nmod	_	_
19	JAK-1	jak-1	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	18	conj	_	_
24	STAT6	stat6	NN	NN	_	23	dep	_	_
25	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	15	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	JAK-3	jak-3	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	associates	associate	VBZ	VBZ	_	6	acl:relcl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	gamma(c)	gamma(c)	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	SCF	scf	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	SCF-mediated	scf-mediated	JJ	JJ	_	2	amod	_	_
2	ligation	ligation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	kit/IL-4R	kit/il-4r	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	sufficient	sufficient	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	elicit	elicit	VB	VB	_	7	xcomp	_	_
10	IL-4-specific	il-4-specific	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	including	include	VBG	VBG	_	15	case	_	_
15	up-regulation	up-regulation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CD23	cd23	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	synthesis	synthesis	NN	NN	_	15	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	germ-line	germ-line	NN	NN	_	23	compound	_	_
22	epsilon	epsilon	NN	NN	_	23	compound	_	_
23	transcripts	transcript	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	T	t	NN	NN	_	6	compound	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	CTLL2	ctll2	NN	NN	_	12	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	ligation	ligation	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	kit/IL-4R	kit/il-4r	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	8	nmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	proliferation	proliferation	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	JAK-1-deficient	jak-1-deficient	JJ	JJ	_	6	amod	_	_
5	HeLa	hela	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	14	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	STAT6	stat6	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	14	nsubjpass	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IL-4	il-4	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	completely	completely	RB	RB	_	14	advmod	_	_
14	abolished	abolish	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	11	det	_	_
8	IL-4R	il-4r	NN	NN	_	11	compound	_	_
9	alpha	alpha	NN	NN	_	11	compound	_	_
10	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	5	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	activate	activate	VB	VB	_	13	ccomp	_	_
16	JAK-1	jak-1	NN	NN	_	15	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	STAT6	stat6	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	induce	induce	VB	VB	_	15	conj	_	_
22	expression	expression	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	IL-4	il-4	NN	NN	_	26	compound	_	_
25	target	target	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	5	punct	_	_
28	thus	thus	RB	RB	_	29	advmod	_	_
29	identifying	identify	VBG	VBG	_	5	xcomp	_	_
30	a	a	DT	DT	_	31	det	_	_
31	mechanism	mechanism	NN	NN	_	29	dobj	_	_
32	by	by	IN	IN	_	33	case	_	_
33	which	which	WDT	WDT	_	37	nmod	_	_
34	IL-4	il-4	NN	NN	_	35	compound	_	_
35	signaling	signaling	NN	NN	_	37	nsubj	_	_
36	can	can	MD	MD	_	37	aux	_	_
37	proceed	proceed	VB	VB	_	31	acl:relcl	_	_
38	in	in	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	absence	absence	NN	NN	_	37	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	JAK-3	jak-3	NN	NN	_	40	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	gamma(c)	gamma(c)	NN	NN	_	42	conj	_	_
45	.	.	.	.	_	5	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	compound	_	_
2	generation	generation	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	8	case	_	_
4	apoptotic	apoptotic	JJ	JJ	_	8	amod	_	_
5	vascular	vascular	JJ	JJ	_	8	amod	_	_
6	smooth	smooth	NN	NN	_	8	compound	_	_
7	muscle	muscle	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	assembly	assembly	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	prothrombinase	prothrombinase	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	coagulation	coagulation	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	on	on	IN	IN	_	17	case	_	_
14	an	a	DT	DT	_	17	det	_	_
15	anionic	anionic	JJ	JJ	_	17	amod	_	_
16	phospholipid	phospholipid	NN	NN	_	17	compound	_	_
17	surface	surface	NN	NN	_	4	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	classically	classically	RB	RB	_	20	advmod	_	_
20	provided	provide	VBN	VBN	_	4	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	activated	activate	VBN	VBN	_	23	amod	_	_
23	platelets	platelet	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	anionic	anionic	JJ	JJ	_	7	amod	_	_
7	phosphatidylserine	phosphatidylserine	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	exposed	expose	VBN	VBN	_	4	ccomp	_	_
10	by	by	IN	IN	_	15	case	_	_
11	rat	rat	NN	NN	_	15	compound	_	_
12	vascular	vascular	JJ	JJ	_	15	amod	_	_
13	smooth	smooth	NN	NN	_	15	compound	_	_
14	muscle	muscle	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	VSMCs	vsmc	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	undergoing	undergo	VBG	VBG	_	15	acl	_	_
20	apoptosis	apoptosis	NN	NN	_	19	dobj	_	_
21	after	after	IN	IN	_	23	case	_	_
22	serum	serum	NN	NN	_	23	compound	_	_
23	withdrawal	withdrawal	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	using	use	VBG	VBG	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	chromogenic	chromogenic	JJ	JJ	_	8	amod	_	_
8	assay	assay	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	5	punct	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	shown	show	VBN	VBN	_	5	parataxis	_	_
13	thrombin	thrombin	NN	NN	_	14	compound	_	_
14	generation	generation	NN	NN	_	12	dobj	_	_
15	by	by	IN	IN	_	17	case	_	_
16	apoptotic	apoptotic	JJ	JJ	_	17	amod	_	_
17	VSMCs	vsmc	NNS	NNS	_	14	nmod	_	_
18	expressing	express	VBG	VBG	_	17	acl	_	_
19	c-myc	c-myc	NN	NN	_	18	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	VSMC-myc	vsmc-myc	NN	NN	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	with	with	IN	IN	_	25	case	_	_
24	an	a	DT	DT	_	25	det	_	_
25	area	area	NN	NN	_	17	nmod	_	_
26	under	under	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	thrombin-generation	thrombin-generation	NN	NN	_	29	compound	_	_
29	curve	curve	NN	NN	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	AUC	auc	NN	NN	_	25	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	of	of	IN	IN	_	37	case	_	_
34	305	305	CD	CD	_	37	nummod	_	_
35	+/-	+/-	CC	CC	_	34	cc	_	_
36	17	17	CD	CD	_	34	conj	_	_
37	nmol	nmol	NN	NN	_	25	nmod	_	_
38	x	x	CC	CC	_	37	cc	_	_
39	min/L	min/l	NN	NN	_	37	conj	_	_
40	and	and	CC	CC	_	25	cc	_	_
41	a	a	DT	DT	_	42	det	_	_
42	peak	peak	NN	NN	_	25	conj	_	_
43	thrombin	thrombin	NN	NN	_	42	dep	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	PT	pt	NN	NN	_	42	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	of	of	IN	IN	_	51	case	_	_
48	154	154	CD	CD	_	51	nummod	_	_
49	+/-	+/-	CC	CC	_	48	cc	_	_
50	9	9	CD	CD	_	48	conj	_	_
51	nmol/L	nmol/l	NN	NN	_	42	nmod	_	_
52	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	thrombin-generating	thrombin-generating	JJ	JJ	_	3	amod	_	_
3	potential	potential	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	apoptotic	apoptotic	JJ	JJ	_	8	amod	_	_
7	VSMC-myc	vsmc-myc	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	greater	greater	JJR	JJR	_	0	root	_	_
11	than	than	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	unactivated	unactivated	JJ	JJ	_	15	amod	_	_
15	platelets	platelet	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	P	p	NN	NN	_	12	dep	_	_
18	=	=	JJ	JJ	_	17	amod	_	_
19	.003	.003	CD	CD	_	18	dep	_	_
20	for	for	IN	IN	_	21	case	_	_
21	AUC	auc	NN	NN	_	17	nmod	_	_
22	;	;	:	:	_	17	punct	_	_
23	P	p	NN	NN	_	17	dep	_	_
24	=	=	JJ	JJ	_	23	amod	_	_
25	.0002	.0002	NN	NN	_	24	dep	_	_
26	for	for	IN	IN	_	27	case	_	_
27	PT	pt	NN	NN	_	23	nmod	_	_
28	)	)	-RRB-	-RRB-	_	17	punct	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	similar	similar	JJ	JJ	_	10	conj	_	_
31	to	to	TO	TO	_	34	case	_	_
32	calcium-ionophore	calcium-ionophore	JJ	JJ	_	34	amod	_	_
33	activated	activate	VBN	VBN	_	34	amod	_	_
34	platelets	platelet	NNS	NNS	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	AUC	auc	NN	NN	_	34	dep	_	_
37	of	of	IN	IN	_	43	case	_	_
38	332	332	CD	CD	_	43	nummod	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	15	15	CD	CD	_	38	conj	_	_
41	nmol	nmol	NN	NN	_	43	compound	_	_
42	x	x	NN	NN	_	43	compound	_	_
43	min/L	min/l	NN	NN	_	36	nmod	_	_
44	,	,	,	,	_	36	punct	_	_
45	P	p	NN	NN	_	36	appos	_	_
46	=	=	JJ	JJ	_	45	amod	_	_
47	.3	.3	NN	NN	_	46	dep	_	_
48	;	;	:	:	_	36	punct	_	_
49	PT	pt	NN	NN	_	36	dep	_	_
50	of	of	IN	IN	_	54	case	_	_
51	172	172	CD	CD	_	54	nummod	_	_
52	+/-	+/-	CC	CC	_	51	cc	_	_
53	8	8	CD	CD	_	51	conj	_	_
54	nmol/L	nmol/l	NN	NN	_	49	nmod	_	_
55	,	,	,	,	_	49	punct	_	_
56	P	p	NN	NN	_	49	appos	_	_
57	=	=	JJ	JJ	_	56	amod	_	_
58	.2	.2	NN	NN	_	57	dep	_	_
59	)	)	-RRB-	-RRB-	_	36	punct	_	_
60	.	.	.	.	_	10	punct	_	_

1	Thrombin	thrombin	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	seen	see	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	apoptotic	apoptotic	JJ	JJ	_	9	amod	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	VSMCs	vsmc	NNS	NNS	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AUC	auc	NN	NN	_	9	dep	_	_
12	of	of	IN	IN	_	18	case	_	_
13	211	211	CD	CD	_	18	nummod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	8	8	CD	CD	_	13	conj	_	_
16	nmol	nmol	NN	NN	_	18	compound	_	_
17	x	x	NN	NN	_	18	compound	_	_
18	min/L	min/l	NN	NN	_	11	nmod	_	_
19	;	;	:	:	_	11	punct	_	_
20	PT	pt	NN	NN	_	11	dep	_	_
21	of	of	IN	IN	_	25	case	_	_
22	103	103	CD	CD	_	25	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	4	4	CD	CD	_	22	conj	_	_
25	nmol/L	nmol/l	NN	NN	_	20	nmod	_	_
26	)	)	-RRB-	-RRB-	_	11	punct	_	_
27	and	and	CC	CC	_	5	cc	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	inhibited	inhibit	VBN	VBN	_	5	conj	_	_
30	by	by	IN	IN	_	32	case	_	_
31	annexin	annexin	NN	NN	_	32	compound	_	_
32	V	v	NN	NN	_	29	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	P	p	NN	NN	_	32	dep	_	_
35	&lt;	&lt;	JJR	JJR	_	34	amod	_	_
36	.0001	.0001	CD	CD	_	35	dep	_	_
37	for	for	IN	IN	_	38	case	_	_
38	AUC	auc	NN	NN	_	34	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	PT	pt	NN	NN	_	38	conj	_	_
41	)	)	-RRB-	-RRB-	_	34	punct	_	_
42	.	.	.	.	_	5	punct	_	_

1	VSMC-myc	vsmc-myc	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	maintained	maintain	VBN	VBN	_	2	acl	_	_
4	in	in	IN	IN	_	5	case	_	_
5	serum	serum	NN	NN	_	3	nmod	_	_
6	generated	generate	VBD	VBD	_	0	root	_	_
7	less	less	RBR	RBR	_	8	advmod	_	_
8	thrombin	thrombin	NN	NN	_	6	dobj	_	_
9	than	than	IN	IN	_	12	case	_	_
10	after	after	IN	IN	_	12	case	_	_
11	serum	serum	NN	NN	_	12	compound	_	_
12	withdrawal	withdrawal	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	P	p	NN	NN	_	6	dep	_	_
15	=	=	JJ	JJ	_	14	amod	_	_
16	.0002	.0002	NN	NN	_	15	dep	_	_
17	for	for	IN	IN	_	18	case	_	_
18	AUC	auc	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	PT	pt	NN	NN	_	18	conj	_	_
21	)	)	-RRB-	-RRB-	_	14	punct	_	_
22	.	.	.	.	_	6	punct	_	_

1	VSMCs	vsmc	NNS	NNS	_	14	nsubj	_	_
2	derived	derive	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	coronary	coronary	JJ	JJ	_	4	dep	_	_
6	atherosclerotic	atherosclerotic	JJ	JJ	_	4	dep	_	_
7	plaques	plaque	NNS	NNS	_	2	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	apoptose	apoptose	VBP	VBP	_	1	acl:relcl	_	_
10	even	even	RB	RB	_	12	advmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	serum	serum	NN	NN	_	9	nmod	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	generated	generate	VBN	VBN	_	0	root	_	_
15	thrombin	thrombin	NN	NN	_	14	dobj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	AUC	auc	NN	NN	_	14	dep	_	_
18	of	of	IN	IN	_	24	case	_	_
19	260	260	CD	CD	_	24	nummod	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	2	2	CD	CD	_	19	conj	_	_
22	nmol	nmol	NN	NN	_	24	compound	_	_
23	x	x	NN	NN	_	24	compound	_	_
24	min/L	min/l	NN	NN	_	17	nmod	_	_
25	;	;	:	:	_	17	punct	_	_
26	PT	pt	NN	NN	_	17	dep	_	_
27	of	of	IN	IN	_	31	case	_	_
28	128	128	CD	CD	_	31	nummod	_	_
29	+/-	+/-	CC	CC	_	28	cc	_	_
30	4	4	CD	CD	_	28	conj	_	_
31	nmol/L	nmol/l	NN	NN	_	26	nmod	_	_
32	)	)	-RRB-	-RRB-	_	17	punct	_	_
33	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	apoptotic	apoptotic	JJ	JJ	_	5	amod	_	_
5	VSMCs	vsmc	NNS	NNS	_	6	nsubj	_	_
6	possess	possess	VBP	VBP	_	2	ccomp	_	_
7	a	a	DT	DT	_	10	det	_	_
8	significant	significant	JJ	JJ	_	10	amod	_	_
9	thrombin-generating	thrombin-generating	NN	NN	_	8	dep	_	_
10	capacity	capacity	NN	NN	_	6	dobj	_	_
11	secondary	secondary	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	phosphatidylserine	phosphatidylserine	NN	NN	_	14	compound	_	_
14	exposure	exposure	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Apoptotic	apoptotic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	7	nsubj	_	_
3	within	within	IN	IN	_	5	case	_	_
4	atherosclerotic	atherosclerotic	JJ	JJ	_	5	amod	_	_
5	plaques	plaque	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	allow	allow	VB	VB	_	0	root	_	_
8	local	local	JJ	JJ	_	10	amod	_	_
9	thrombin	thrombin	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	thereby	thereby	RB	RB	_	13	advmod	_	_
13	contributing	contribute	VBG	VBG	_	7	advcl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	disease	disease	NN	NN	_	16	compound	_	_
16	progression	progression	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	interferon-gamma-induced	interferon-gamma-induced	JJ	JJ	_	8	amod	_	_
4	intercellular	intercellular	JJ	JJ	_	7	amod	_	_
5	adhesion	adhesion	NN	NN	_	7	compound	_	_
6	molecule-1	molecule-1	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	2	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-10	il-10	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	a	a	DT	DT	_	10	det	_	_
7	potent	potent	JJ	JJ	_	10	amod	_	_
8	monocyte	monocyte	NN	NN	_	10	compound	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	cytokine	cytokine	NN	NN	_	0	root	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	inhibits	inhibit	VBZ	VBZ	_	10	acl:relcl	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	proinflammatory	proinflammatory	JJ	JJ	_	17	amod	_	_
17	mediators	mediator	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	12	nmod	_	_
11	IL-10	il-10	NN	NN	_	12	nsubj	_	_
12	downregulates	downregulate	VBZ	VBZ	_	8	acl:relcl	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	intercellular	intercellular	JJ	JJ	_	17	amod	_	_
16	adhesion	adhesion	NN	NN	_	17	compound	_	_
17	molecule-1	molecule-1	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ICAM-1	icam-1	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	on	on	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	surface	surface	NN	NN	_	12	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	normal	normal	JJ	JJ	_	28	amod	_	_
27	human	human	JJ	JJ	_	28	amod	_	_
28	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
29	activated	activate	VBN	VBN	_	28	acl	_	_
30	with	with	IN	IN	_	31	case	_	_
31	interferon-gamma	interferon-gamma	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	IFN-gamma	ifn-gamma	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	6	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	inhibition	inhibition	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	6	amod	_	_
5	ICAM-1	icam-1	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	apparent	apparent	JJ	JJ	_	0	root	_	_
9	as	as	RB	RB	_	10	advmod	_	_
10	early	early	RB	RB	_	8	advmod	_	_
11	as	as	IN	IN	_	13	case	_	_
12	3	3	CD	CD	_	13	nummod	_	_
13	hours	hour	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	blocked	block	VBN	VBN	_	8	conj	_	_
17	by	by	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	anti-IL-10	anti-il-10	JJ	JJ	_	20	amod	_	_
20	antibody	antibody	NN	NN	_	16	nmod	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	not	not	RB	RB	_	27	neg	_	_
23	by	by	IN	IN	_	27	case	_	_
24	an	a	DT	DT	_	27	det	_	_
25	isotype-matched	isotype-matched	JJ	JJ	_	27	amod	_	_
26	control	control	JJ	JJ	_	27	amod	_	_
27	antibody	antibody	NN	NN	_	20	conj	_	_
28	.	.	.	.	_	8	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	IL-10	il-10	NN	NN	_	7	nsubj	_	_
7	reduced	reduce	VBD	VBD	_	4	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	accumulation	accumulation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	ICAM-1	icam-1	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	IFN-gamma-stimulated	ifn-gamma-stimulated	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	inhibition	inhibition	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	ICAM-1	icam-1	NN	NN	_	6	compound	_	_
5	steady-state	steady-state	JJ	JJ	_	6	amod	_	_
6	mRNA	mrna	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	11	case	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	hours	hour	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	remained	remain	VBD	VBD	_	8	conj	_	_
14	at	at	IN	IN	_	16	case	_	_
15	24	24	CD	CD	_	16	nummod	_	_
16	hours	hour	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	run-on	run-on	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	IL-10	il-10	NN	NN	_	8	nsubj	_	_
8	inhibited	inhibit	VBD	VBD	_	5	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	rate	rate	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	ICAM-1	icam-1	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	mRNA	mrna	NN	NN	_	22	compound	_	_
21	stability	stability	NN	NN	_	22	compound	_	_
22	studies	study	NNS	NNS	_	23	nsubj	_	_
23	showed	show	VBD	VBD	_	5	conj	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	IL-10	il-10	NN	NN	_	28	nsubj	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	alter	alter	VB	VB	_	23	ccomp	_	_
29	the	the	DT	DT	_	30	det	_	_
30	half-life	half-life	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	34	amod	_	_
33	ICAM-1	icam-1	NN	NN	_	34	compound	_	_
34	message	message	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-10	il-10	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	7	amod	_	_
6	ICAM-1	icam-1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	primarily	primarily	RB	RB	_	13	advmod	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IFN-gamma-responsive	ifn-gamma-responsive	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	STAT-1alpha	stat-1alpha	NN	NN	_	11	dep	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	transducer	transducer	NN	NN	_	12	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	activator	activator	NN	NN	_	19	compound	_	_
18	of	of	IN	IN	_	19	amod	_	_
19	transcription-1alpha	transcription-1alpha	NN	NN	_	15	conj	_	_
20	)	)	-RRB-	-RRB-	_	15	punct	_	_
21	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	IL-10	il-10	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	affect	affect	VB	VB	_	0	root	_	_
7	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	9	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	STAT-1alpha	stat-1alpha	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	6	cc	_	_
13	alter	alter	VB	VB	_	6	conj	_	_
14	STAT-1alpha	stat-1alpha	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IRE	ire	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	ICAM-1	icam-1	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	15	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Instead	instead	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-10	il-10	NN	NN	_	4	nsubj	_	_
4	prevented	prevent	VBD	VBD	_	0	root	_	_
5	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	7	amod	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	24	case	_	_
13	the	the	DT	DT	_	24	det	_	_
14	tumor	tumor	NN	NN	_	24	compound	_	_
15	necrosis	necrosis	NN	NN	_	24	compound	_	_
16	factor	factor	NN	NN	_	24	compound	_	_
17	alpha	alpha	NN	NN	_	24	compound	_	_
18	(	(	-LRB-	-LRB-	_	24	punct	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	24	compound	_	_
20	)	)	-RRB-	-RRB-	_	24	punct	_	_
21	-responsive	-responsive	JJ	JJ	_	24	amod	_	_
22	NF-kappaB/C-EBP	nf-kappab/c-ebp	NN	NN	_	24	compound	_	_
23	composite	composite	NN	NN	_	24	compound	_	_
24	element	element	NN	NN	_	11	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	ICAM-1	icam-1	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	7	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IL-10	il-10	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
7	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	ICAM-1	icam-1	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	mechanism	mechanism	NN	NN	_	6	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	involve	involve	VB	VB	_	16	acl:relcl	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Comparison	comparison	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transactivation	transactivation	NN	NN	_	5	compound	_	_
5	domains	domain	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Stat5	stat5	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Stat6	stat6	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	mammary	mammary	JJ	JJ	_	16	amod	_	_
15	epithelial	epithelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	1	punct	_	_

1	Stat	stat	NN	NN	_	19	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transducers	transducer	NNS	NNS	_	1	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	activators	activator	NNS	NNS	_	8	compound	_	_
7	of	of	IN	IN	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	4	conj	_	_
9	)	)	-RRB-	-RRB-	_	4	punct	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	Jak	jak	NN	NN	_	1	conj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	Janus	janus	NN	NN	_	14	compound	_	_
14	kinases	kinase	NNS	NNS	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	proteins	protein	NNS	NNS	_	1	dep	_	_
17	are	be	VBP	VBP	_	19	cop	_	_
18	central	central	JJ	JJ	_	19	amod	_	_
19	components	component	NNS	NNS	_	0	root	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	signal	signal	NN	NN	_	24	compound	_	_
23	transduction	transduction	NN	NN	_	24	compound	_	_
24	events	event	NNS	NNS	_	19	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	hematopoietic	hematopoietic	JJ	JJ	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	epithelial	epithelial	JJ	JJ	_	26	conj	_	_
29	cells	cell	NNS	NNS	_	26	dep	_	_
30	.	.	.	.	_	19	punct	_	_

1	They	they	PRP	PRP	_	4	nsubjpass	_	_
2	are	be	VBP	VBP	_	4	auxpass	_	_
3	rapidly	rapidly	RB	RB	_	4	advmod	_	_
4	activated	activate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	various	various	JJ	JJ	_	7	amod	_	_
7	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	hormones	hormone	NNS	NNS	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	growth	growth	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	7	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	ligand	ligand	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	12	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	cytokine	cytokine	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	dimerization	dimerization	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	Stat	stat	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
13	on	on	IN	IN	_	15	case	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	residues	residue	NNS	NNS	_	12	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	Jak	jak	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Activated	activate	VBN	VBN	_	3	amod	_	_
2	Stat	stat	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	form	form	VBP	VBP	_	0	root	_	_
5	homo-	homo-	JJ	JJ	_	4	dobj	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	heterodimers	heterodimer	NNS	NNS	_	5	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	translocate	translocate	VBP	VBP	_	4	conj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	nucleus	nucleus	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	induce	induce	VBP	VBP	_	4	conj	_	_
16	transcription	transcription	NN	NN	_	15	dobj	_	_
17	from	from	IN	IN	_	19	case	_	_
18	responsive	responsive	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Stat5	stat5	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Stat6	stat6	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	0	root	_	_
7	active	active	JJ	JJ	_	6	amod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	mammary	mammary	JJ	JJ	_	11	amod	_	_
10	epithelial	epithelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	Prolactin	prolactin	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	Stat5	stat5	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	2	punct	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	interleukin-4	interleukin-4	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-4	il-4	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	activates	activate	VBZ	VBZ	_	2	conj	_	_
11	Stat6	stat6	NN	NN	_	10	dobj	_	_
12	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	dep	_	_
2	cytokines	cytokine	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	able	able	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	stimulate	stimulate	VB	VB	_	4	xcomp	_	_
7	cell	cell	NN	NN	_	6	dobj	_	_
8	proliferation	proliferation	NN	NN	_	7	dep	_	_
9	,	,	,	,	_	7	punct	_	_
10	differentiation	differentiation	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	survival	survival	NN	NN	_	7	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transactivation	transactivation	NN	NN	_	5	compound	_	_
5	potential	potential	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Stat6	stat6	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	found	find	VBD	VBD	_	2	conj	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	it	it	PRP	PRP	_	14	nsubj	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	restricted	restricted	JJ	JJ	_	9	ccomp	_	_
15	to	to	TO	TO	_	16	case	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	IL-4-dependent	il-4-dependent	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Stat6	stat6	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	HC11	hc11	NN	NN	_	12	compound	_	_
10	mammary	mammary	JJ	JJ	_	12	amod	_	_
11	epithelial	epithelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	Stat6	stat6	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	7	nsubj	_	_
7	led	lead	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	beta-casein	beta-casein	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	COS7	cos7	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	further	further	RB	RB	_	8	advmod	_	_
8	enhance	enhance	VB	VB	_	5	xcomp	_	_
9	IL-4-induced	il-4-induced	JJ	JJ	_	11	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	8	dobj	_	_
12	through	through	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	action	action	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Stat6	stat6	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Stat6	stat6	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	recombination	recombination	NN	NN	_	2	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	region	region	NN	NN	_	10	nmod	_	_
14	with	with	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	heterologous	heterologous	JJ	JJ	_	19	amod	_	_
17	DNA	dna	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	10	nmod	_	_
20	allowed	allow	VBD	VBD	_	0	root	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	delimitation	delimitation	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	characterization	characterization	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transactivation	transactivation	NN	NN	_	28	compound	_	_
28	domain	domain	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	Stat6	stat6	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	potencies	potency	NNS	NNS	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transactivation	transactivation	NN	NN	_	6	compound	_	_
6	domains	domain	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Stat5	stat5	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	Stat6	stat6	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	viral	viral	JJ	JJ	_	15	amod	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	VP16	vp16	NN	NN	_	8	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	compared	compare	VBN	VBN	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Stat6	stat6	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transactivation	transactivation	NN	NN	_	5	compound	_	_
5	domain	domain	NN	NN	_	2	dobj	_	_
6	which	which	WDT	WDT	_	10	nsubj	_	_
7	was	be	VBD	VBD	_	10	cop	_	_
8	about	about	RB	RB	_	9	advmod	_	_
9	10-fold	10-fold	RB	RB	_	10	nmod:npmod	_	_
10	stronger	stronger	JJR	JJR	_	5	acl:relcl	_	_
11	than	than	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Stat5	stat5	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	pre-B	pre-b	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	15	nmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	Ba/F3	ba/f3	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	15	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transactivation	transactivation	NN	NN	_	10	compound	_	_
10	domain	domain	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Stat6	stat6	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	15	cop	_	_
14	IL-4	il-4	NN	NN	_	15	nmod:npmod	_	_
15	regulated	regulated	JJ	JJ	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	independently	independently	RB	RB	_	15	advmod	_	_
18	from	from	IN	IN	_	22	case	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	DNA	dna	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	function	function	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	immediate-early	immediate-early	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	product	product	NN	NN	_	6	nsubj	_	_
5	Egr-1	egr-1	NN	NN	_	4	dep	_	_
6	regulates	regulate	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	12	det	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	interleukin-2	interleukin-2	NN	NN	_	12	compound	_	_
10	receptor	receptor	NN	NN	_	12	compound	_	_
11	beta-chain	beta-chain	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	6	dobj	_	_
13	through	through	IN	IN	_	15	case	_	_
14	noncanonical	noncanonical	JJ	JJ	_	15	amod	_	_
15	Egr	egr	NN	NN	_	6	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Sp1	sp1	NN	NN	_	15	conj	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	15	dep	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	interleukin-2	interleukin-2	NN	NN	_	5	compound	_	_
3	IL-2	il-2	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	beta-chain	beta-chain	NN	NN	_	12	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-2Rbeta	il-2rbeta	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	an	a	DT	DT	_	12	det	_	_
11	essential	essential	JJ	JJ	_	12	amod	_	_
12	component	component	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	receptors	receptor	NNS	NNS	_	12	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	IL-2	il-2	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-15	il-15	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	12	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	IL-2Rbeta	il-2rbeta	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	constitutively	constitutively	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	14	advcl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	expression	expression	NN	NN	_	14	nsubjpass	_	_
11	can	can	MD	MD	_	14	aux	_	_
12	be	be	VB	VB	_	14	auxpass	_	_
13	further	further	RB	RB	_	14	advmod	_	_
14	induced	induce	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	number	number	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	stimuli	stimulus	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	17	punct	_	_
21	including	include	VBG	VBG	_	24	case	_	_
22	phorbol	phorbol	NN	NN	_	24	compound	_	_
23	12-myristate	12-myristate	NN	NN	_	24	compound	_	_
24	13-acetate	13-acetate	NN	NN	_	17	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PMA	pma	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	factors	factor	NNS	NNS	_	4	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	7	nmod	_	_
12	located	located	JJ	JJ	_	11	amod	_	_
13	between	between	IN	IN	_	14	case	_	_
14	nucleotides	nucleotide	NNS	NNS	_	12	nmod	_	_
15	-170	-170	CD	CD	_	14	nummod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	-139	-139	CD	CD	_	14	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	IL-2Rbeta	il-2rbeta	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	Sp1	sp1	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Sp3	sp3	NN	NN	_	2	conj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	5'	5'	JJ	JJ	_	9	amod	_	_
9	portion	portion	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	this	this	DT	DT	_	12	det	_	_
12	region	region	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	whereas	whereas	IN	IN	_	22	mark	_	_
15	a	a	DT	DT	_	17	det	_	_
16	PMA-inducible	pma-inducible	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	22	nsubj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PIF	pif	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	mainly	mainly	RB	RB	_	22	advmod	_	_
22	bound	bind	VBD	VBD	_	5	advcl	_	_
23	to	to	TO	TO	_	26	case	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	3'	3'	JJ	JJ	_	26	amod	_	_
26	portion	portion	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	bound	bind	VBD	VBD	_	22	conj	_	_
29	to	to	TO	TO	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	Sp	sp	NN	NN	_	33	compound	_	_
32	binding	binding	NN	NN	_	33	compound	_	_
33	motifs	motif	NNS	NNS	_	28	nmod	_	_
34	as	as	RB	RB	_	28	advmod	_	_
35	well	well	RB	RB	_	34	mwe	_	_
36	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	Jurkat	jurkat	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	induction	induction	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	PIF	pif	NN	NN	_	11	compound	_	_
9	DNA	dna	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	6	nmod	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	rapidly	rapidly	RB	RB	_	14	advmod	_	_
14	induced	induce	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	required	require	VBD	VBD	_	14	conj	_	_
17	de	de	FW	FW	_	20	amod	_	_
18	novo	novo	FW	FW	_	17	dep	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	16	dobj	_	_
21	,	,	,	,	_	14	punct	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	sustained	sustained	JJ	JJ	_	14	conj	_	_
25	at	at	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	high	high	JJ	JJ	_	28	amod	_	_
28	level	level	NN	NN	_	24	nmod	_	_
29	for	for	IN	IN	_	33	case	_	_
30	at	at	IN	IN	_	31	case	_	_
31	least	least	JJS	JJS	_	32	nmod:npmod	_	_
32	23	23	CD	CD	_	33	nummod	_	_
33	h	h	NN	NN	_	24	nmod	_	_
34	.	.	.	.	_	14	punct	_	_

1	Interestingly	interestingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	PIF	pif	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	activated	activate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	15	case	_	_
8	human	human	JJ	JJ	_	15	amod	_	_
9	T-cell	t-cell	NN	NN	_	15	compound	_	_
10	leukemia	leukemia	NN	NN	_	15	compound	_	_
11	virus	virus	NN	NN	_	15	compound	_	_
12	type	type	NN	NN	_	15	compound	_	_
13	1-transformed	1-transformed	JJ	JJ	_	15	amod	_	_
14	MT-2	mt-2	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	6	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	PIF	pif	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	Egr-1	egr-1	NN	NN	_	6	ccomp	_	_
11	based	base	VBN	VBN	_	14	case	_	_
12	on	on	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	recognition	recognition	NN	NN	_	10	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	anti-Egr-1	anti-egr-1	JJ	JJ	_	17	amod	_	_
17	antisera	antisera	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	gel	gel	NN	NN	_	22	compound	_	_
20	mobility	mobility	NN	NN	_	22	compound	_	_
21	shift	shift	NN	NN	_	22	compound	_	_
22	assays	assay	NNS	NNS	_	14	nmod	_	_
23	,	,	,	,	_	10	punct	_	_
24	even	even	RB	RB	_	31	advmod	_	_
25	though	though	IN	IN	_	31	mark	_	_
26	the	the	DT	DT	_	30	det	_	_
27	IL-2Rbeta	il-2rbeta	NN	NN	_	30	compound	_	_
28	DNA	dna	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	motif	motif	NN	NN	_	31	nsubj	_	_
31	differed	differ	VBD	VBD	_	10	advcl	_	_
32	substantially	substantially	RB	RB	_	31	advmod	_	_
33	from	from	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	canonical	canonical	JJ	JJ	_	38	amod	_	_
36	Egr-1	egr-1	NN	NN	_	38	compound	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	site	site	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	Egr-1	egr-1	NN	NN	_	5	nsubj	_	_
5	bound	bind	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	Sp	sp	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	both	both	DT	DT	_	6	det	_	_
6	sites	site	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	13	case	_	_
10	maximal	maximal	JJ	JJ	_	13	amod	_	_
11	IL-2Rbeta	il-2rbeta	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	in	in	IN	IN	_	18	case	_	_
17	HeLaS3	helas3	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	24	nmod	_	_
19	,	,	,	,	_	24	punct	_	_
20	transfection	transfection	NN	NN	_	24	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Egr-1	egr-1	NN	NN	_	20	nmod	_	_
23	could	could	MD	MD	_	24	aux	_	_
24	drive	drive	VB	VB	_	8	conj	_	_
25	activity	activity	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	reporter	reporter	NN	NN	_	29	compound	_	_
29	construct	construct	NN	NN	_	25	nmod	_	_
30	containing	contain	VBG	VBG	_	29	acl	_	_
31	both	both	DT	DT	_	32	det	_	_
32	sites	site	NNS	NNS	_	30	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	Sp1	sp1	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Egr-1	egr-1	NN	NN	_	3	conj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	form	form	VB	VB	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	complex	complex	NN	NN	_	7	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	kinetics	kinetics	NNS	NNS	_	9	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	correlated	correlate	VBD	VBD	_	11	acl:relcl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	production	production	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Egr-1	egr-1	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	Jurkat	jurkat	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	upon	upon	IN	IN	_	24	case	_	_
23	PMA	pma	NN	NN	_	24	compound	_	_
24	stimulation	stimulation	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	Sp1	sp1	NN	NN	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Egr-1	egr-1	NN	NN	_	3	conj	_	_
6	physically	physically	RB	RB	_	7	advmod	_	_
7	and	and	CC	CC	_	9	advmod	_	_
8	functionally	functionally	RB	RB	_	7	advmod	_	_
9	cooperate	cooperate	VBP	VBP	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	mediate	mediate	VB	VB	_	9	xcomp	_	_
12	maximal	maximal	JJ	JJ	_	15	amod	_	_
13	IL-2Rbeta	il-2rbeta	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	9	punct	_	_

1	Chimeric	chimeric	JJ	JJ	_	2	amod	_	_
2	oncoprotein	oncoprotein	NN	NN	_	4	nsubj	_	_
3	E2a-Pbx1	e2a-pbx1	NN	NN	_	2	dep	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	apoptosis	apoptosis	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	hematopoietic	hematopoietic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	p53-independent	p53-independent	JJ	JJ	_	12	amod	_	_
12	mechanism	mechanism	NN	NN	_	4	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	suppressed	suppress	VBN	VBN	_	12	acl:relcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	Bcl-2	bcl-2	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chimeric	chimeric	JJ	JJ	_	3	amod	_	_
3	oncoprotein	oncoprotein	NN	NN	_	5	nsubj	_	_
4	E2a-Pbx1	e2a-pbx1	NN	NN	_	3	dep	_	_
5	results	result	VBZ	VBZ	_	0	root	_	_
6	from	from	IN	IN	_	7	case	_	_
7	fusion	fusion	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	E2A	e2a	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	PBX1	pbx1	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	10	dep	_	_
14	following	follow	VBG	VBG	_	17	case	_	_
15	t(1;19)	t(1;19)	NN	NN	_	17	compound	_	_
16	chromosomal	chromosomal	JJ	JJ	_	17	amod	_	_
17	translocations	translocation	NNS	NNS	_	7	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	B	b	NN	NN	_	23	compound	_	_
20	cell	cell	NN	NN	_	23	compound	_	_
21	precursor	precursor	NN	NN	_	23	compound	_	_
22	acute	acute	JJ	JJ	_	23	amod	_	_
23	leukemias	leukemia	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Experimentally	experimentally	RB	RB	_	7	advmod	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	progenitors	progenitor	NNS	NNS	_	7	nsubj	_	_
5	do	do	VBP	VBP	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	tolerate	tolerate	VB	VB	_	0	root	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	E2a-Pbx1	e2a-pbx1	NN	NN	_	9	nmod	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	contrasts	contrast	VBZ	VBZ	_	9	acl:relcl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	transformation	transformation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	other	other	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	15	nmod	_	_
21	following	follow	VBG	VBG	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	stable	stable	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	15	nmod	_	_
25	both	both	CC	CC	_	28	cc:preconj	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	28	advmod	_	_
28	and	and	CC	CC	_	24	advmod	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vivo	vivo	FW	FW	_	28	advmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	investigate	investigate	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	E2a-Pbx1	e2a-pbx1	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	progenitors	progenitor	NNS	NNS	_	5	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	conditionally	conditionally	RB	RB	_	16	advmod	_	_
16	expressed	express	VBD	VBD	_	3	parataxis	_	_
17	E2a-Pbx1	e2a-pbx1	NN	NN	_	16	dobj	_	_
18	under	under	IN	IN	_	19	case	_	_
19	control	control	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	metal	metal	JJ	JJ	_	24	amod	_	_
23	response	response	NN	NN	_	24	compound	_	_
24	element	element	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
27	precursor	precursor	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	16	nmod	_	_
30	in	in	FW	FW	_	31	compound	_	_
31	vitro	vitro	FW	FW	_	16	advmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Inducible	inducible	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E2a-Pbx1	e2a-pbx1	NN	NN	_	2	nmod	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	death	death	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	dep	_	_
11	morphologic	morphologic	JJ	JJ	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	molecular	molecular	JJ	JJ	_	11	conj	_	_
14	features	feature	NNS	NNS	_	11	dep	_	_
15	of	of	IN	IN	_	16	case	_	_
16	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	structure-function	structure-function	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	induction	induction	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	13	cop	_	_
10	not	not	RB	RB	_	13	neg	_	_
11	a	a	DT	DT	_	13	det	_	_
12	dominant-negative	dominant-negative	JJ	JJ	_	13	amod	_	_
13	effect	effect	NN	NN	_	4	ccomp	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	E2a	e2a	NN	NN	_	17	compound	_	_
17	moiety	moiety	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	,	,	,	,	_	13	punct	_	_
20	rather	rather	RB	RB	_	13	advmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	required	require	VBD	VBD	_	13	dep	_	_
23	the	the	DT	DT	_	25	det	_	_
24	DNA-binding	dna-binding	JJ	JJ	_	25	amod	_	_
25	homeodomain	homeodomain	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	Pbx1	pbx1	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	E2a-Pbx1-induced	e2a-pbx1-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	3	nsubj	_	_
3	proceeded	proceed	VBD	VBD	_	0	root	_	_
4	through	through	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	BCL2-responsive	bcl2-responsive	JJ	JJ	_	7	amod	_	_
7	checkpoint	checkpoint	NN	NN	_	3	nmod	_	_
8	eventuating	eventuating	NN	NN	_	7	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	PARP	parp	NN	NN	_	11	compound	_	_
11	inactivation	inactivation	NN	NN	_	8	nmod	_	_
12	but	but	CC	CC	_	3	cc	_	_
13	did	do	VBD	VBD	_	14	aux	_	_
14	require	require	VB	VB	_	3	conj	_	_
15	p53	p53	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E2a-Pbx1	e2a-pbx1	NN	NN	_	2	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	induce	induce	VB	VB	_	0	root	_	_
8	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	continued	continued	JJ	JJ	_	11	amod	_	_
11	cycling	cycling	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Rat-1	rat-1	NN	NN	_	14	compound	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	low	low	JJ	JJ	_	18	amod	_	_
17	serum	serum	NN	NN	_	18	compound	_	_
18	conditions	condition	NNS	NNS	_	7	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	E2a-Pbx1	e2a-pbx1	NN	NN	_	6	nsubj	_	_
6	initiates	initiate	VBZ	VBZ	_	3	ccomp	_	_
7	programmed	program	VBN	VBN	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	death	death	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
12	precursers	precurser	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	mechanism	mechanism	NN	NN	_	6	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	requires	require	VBZ	VBZ	_	15	acl:relcl	_	_
18	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
19	chimeric	chimeric	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	19	dep	_	_
21	properties	property	NNS	NNS	_	17	dobj	_	_
22	,	,	,	,	_	6	punct	_	_
23	but	but	CC	CC	_	6	cc	_	_
24	,	,	,	,	_	6	punct	_	_
25	unlike	unlike	IN	IN	_	28	case	_	_
26	other	other	JJ	JJ	_	28	amod	_	_
27	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
28	oncoproteins	oncoprotein	NNS	NNS	_	6	conj	_	_
29	,	,	,	,	_	6	punct	_	_
30	is	be	VBZ	VBZ	_	31	cop	_	_
31	independent	independent	JJ	JJ	_	6	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	p53	p53	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
4	factor-kappa	factor-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	beta-amyloid	beta-amyloid	NN	NN	_	8	compound	_	_
8	peptides	peptide	NNS	NNS	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	interferon-gamma	interferon-gamma	NN	NN	_	8	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	murine	murine	JJ	JJ	_	13	amod	_	_
13	microglia	microglium	NNS	NNS	_	1	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	increasing	increase	VBG	VBG	_	3	amod	_	_
3	body	body	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	evidence	evidence	NN	NN	_	3	nmod	_	_
6	suggests	suggest	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	amyloid-beta	amyloid-beta	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	A	a	NN	NN	_	11	compound	_	_
11	beta	beta	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	peptides	peptide	NNS	NNS	_	18	nsubjpass	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	microglia	microglium	NNS	NNS	_	13	conj	_	_
16	are	be	VBP	VBP	_	18	auxpass	_	_
17	crucially	crucially	RB	RB	_	18	advmod	_	_
18	involved	involve	VBN	VBN	_	6	ccomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	pathogenesis	pathogenesis	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	Alzheimer	alzheimer	NN	NN	_	25	nmod:poss	_	_
24	's	's	POS	POS	_	25	case	_	_
25	disease	disease	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	effort	effort	NN	NN	_	17	nmod	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	further	further	RB	RB	_	6	advmod	_	_
6	elucidate	elucidate	VB	VB	_	3	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	biological	biological	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	A	a	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	9	nmod	_	_
13	towards	towards	IN	IN	_	14	case	_	_
14	microglia	microglium	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	investigated	investigate	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ability	ability	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	A	a	NN	NN	_	23	compound	_	_
22	beta	beta	NN	NN	_	23	compound	_	_
23	peptides	peptide	NNS	NNS	_	19	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	activate	activate	VB	VB	_	19	acl	_	_
26	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
27	factor	factor	NN	NN	_	32	compound	_	_
28	(	(	-LRB-	-LRB-	_	32	punct	_	_
29	NF	nf	NN	NN	_	32	compound	_	_
30	)	)	-RRB-	-RRB-	_	32	punct	_	_
31	-kappa	-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	25	dobj	_	_
33	in	in	IN	IN	_	39	case	_	_
34	the	the	DT	DT	_	39	det	_	_
35	N9	n9	NN	NN	_	39	compound	_	_
36	murine	murine	JJ	JJ	_	39	amod	_	_
37	microglial	microglial	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	line	line	NN	NN	_	25	nmod	_	_
40	.	.	.	.	_	17	punct	_	_

1	Co-stimulation	co-stimulation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	microglia	microglium	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	suboptimal	suboptimal	JJ	JJ	_	6	amod	_	_
6	concentrations	concentration	NNS	NNS	_	1	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	A	a	NN	NN	_	9	compound	_	_
9	beta	beta	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	25-35	25-35	CD	CD	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	100	100	CD	CD	_	15	compound	_	_
15	U/ml	u/ml	NN	NN	_	17	amod	_	_
16	IFN	ifn	NN	NN	_	17	compound	_	_
17	gamma	gamma	NN	NN	_	9	conj	_	_
18	resulted	result	VBD	VBD	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	detection	detection	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	28	case	_	_
23	a	a	DT	DT	_	28	det	_	_
24	specific	specific	JJ	JJ	_	28	amod	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	28	compound	_	_
27	DNA-binding	dna-binding	JJ	JJ	_	28	amod	_	_
28	activity	activity	NN	NN	_	21	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	extracts	extract	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	18	punct	_	_
33	as	as	IN	IN	_	34	mark	_	_
34	determined	determine	VBN	VBN	_	18	advcl	_	_
35	in	in	IN	IN	_	39	case	_	_
36	gel	gel	NN	NN	_	39	compound	_	_
37	mobility	mobility	NN	NN	_	39	compound	_	_
38	shift	shift	NN	NN	_	39	compound	_	_
39	assays	assay	NNS	NNS	_	34	nmod	_	_
40	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	response	response	NN	NN	_	3	nsubj	_	_
3	required	require	VBD	VBD	_	0	root	_	_
4	at	at	IN	IN	_	5	case	_	_
5	least	least	JJS	JJS	_	6	nmod:npmod	_	_
6	120	120	CD	CD	_	7	nummod	_	_
7	min	min	NN	NN	_	3	dobj	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	evident	evident	JJ	JJ	_	3	xcomp	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	supershift	supershift	NN	NN	_	13	compound	_	_
13	experiments	experiment	NNS	NNS	_	14	nsubj	_	_
14	revealed	reveal	VBD	VBD	_	3	conj	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	the	the	DT	DT	_	19	det	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	20	nsubj	_	_
20	contains	contain	VBZ	VBZ	_	14	ccomp	_	_
21	both	both	CC	CC	_	22	cc:preconj	_	_
22	RelA	rela	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	p50	p50	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Accordingly	accordingly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	immunoblot	immunoblot	NN	NN	_	4	compound	_	_
4	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	amongst	amongst	IN	IN	_	10	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B/Rel	b/rel	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	16	nmod	_	_
11	,	,	,	,	_	16	punct	_	_
12	RelA	rela	NN	NN	_	16	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	p50	p50	NN	NN	_	12	conj	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	mobilized	mobilize	VBN	VBN	_	5	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	nucleus	nucleus	NN	NN	_	16	nmod	_	_
20	following	follow	VBG	VBG	_	23	case	_	_
21	microglial	microglial	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	stimulation	stimulation	NN	NN	_	16	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	A	a	NN	NN	_	26	compound	_	_
26	beta	beta	NN	NN	_	23	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	25-35	25-35	CD	CD	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	plus	plus	CC	CC	_	26	cc	_	_
31	IFN	ifn	NN	NN	_	32	compound	_	_
32	gamma	gamma	NN	NN	_	26	conj	_	_
33	.	.	.	.	_	5	punct	_	_

1	Higher	higher	JJR	JJR	_	2	amod	_	_
2	concentrations	concentration	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	A	a	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	25-35	25-35	CD	CD	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	effective	effective	JJ	JJ	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	themselves	themselves	PRP	PRP	_	10	nmod	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	inducing	induce	VBG	VBG	_	10	advcl	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	14	punct	_	_
19	both	both	CC	CC	_	25	cc:preconj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	N9	n9	NN	NN	_	25	compound	_	_
23	microglial	microglial	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	line	line	NN	NN	_	14	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	in	in	IN	IN	_	30	case	_	_
28	rat	rat	NN	NN	_	30	compound	_	_
29	primary	primary	JJ	JJ	_	30	amod	_	_
30	microglia	microglium	NNS	NNS	_	25	conj	_	_
31	,	,	,	,	_	25	punct	_	_
32	as	as	RB	RB	_	25	cc	_	_
33	well	well	RB	RB	_	32	mwe	_	_
34	as	as	IN	IN	_	32	mwe	_	_
35	in	in	IN	IN	_	37	case	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	monocytes	monocyte	NNS	NNS	_	25	conj	_	_
38	.	.	.	.	_	10	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	purposes	purpose	NNS	NNS	_	9	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	comparison	comparison	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	microglia	microglium	NNS	NNS	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	stimulated	stimulate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	bacterial	bacterial	JJ	JJ	_	12	amod	_	_
12	LPS	lps	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	18	det	_	_
15	known	known	JJ	JJ	_	18	amod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	inducer	inducer	NN	NN	_	12	appos	_	_
19	.	.	.	.	_	9	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	6	advcl	_	_
3	,	,	,	,	_	6	punct	_	_
4	LPS	lps	NN	NN	_	6	nsubj	_	_
5	strongly	strongly	RB	RB	_	6	advmod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	formation	formation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	two	two	CD	CD	_	14	nummod	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	DNA-binding	dna-binding	NN	NN	_	14	compound	_	_
14	activities	activity	NNS	NNS	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	one	one	CD	CD	_	20	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	16	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	identified	identify	VBN	VBN	_	14	acl:relcl	_	_
21	as	as	IN	IN	_	22	case	_	_
22	RelA/p50	rela/p50	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	LPS	lps	NN	NN	_	3	compound	_	_
3	response	response	NN	NN	_	7	nsubj	_	_
4	was	be	VBD	VBD	_	7	cop	_	_
5	also	also	RB	RB	_	7	advmod	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	rapid	rapid	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	as	as	IN	IN	_	13	mark	_	_
10	it	it	PRP	PRP	_	13	nsubj	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	already	already	RB	RB	_	13	advmod	_	_
13	evident	evident	JJ	JJ	_	7	advcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	40	40	CD	CD	_	16	nummod	_	_
16	min	min	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	remained	remain	VBD	VBD	_	13	conj	_	_
19	sustained	sustained	JJ	JJ	_	18	xcomp	_	_
20	for	for	IN	IN	_	24	case	_	_
21	up	up	CD	CD	_	23	compound	_	_
22	to	to	TO	TO	_	23	dep	_	_
23	3	3	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Collectively	collectively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	11	nsubj	_	_
10	might	might	MD	MD	_	11	aux	_	_
11	constitute	constitute	VB	VB	_	5	ccomp	_	_
12	one	one	CD	CD	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanisms	mechanism	NNS	NNS	_	12	nmod	_	_
16	underlying	underlie	VBG	VBG	_	12	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	inducible	inducible	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B-dependent	b-dependent	JJ	JJ	_	23	amod	_	_
23	genes	gene	NNS	NNS	_	19	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	microglia	microglium	NNS	NNS	_	19	nmod	_	_
26	stimulated	stimulate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	30	case	_	_
28	A	a	NN	NN	_	30	compound	_	_
29	beta	beta	NN	NN	_	30	compound	_	_
30	peptides	peptide	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	IFN	ifn	NN	NN	_	33	compound	_	_
33	gamma	gamma	NN	NN	_	30	conj	_	_
34	,	,	,	,	_	30	punct	_	_
35	or	or	CC	CC	_	30	cc	_	_
36	by	by	IN	IN	_	37	case	_	_
37	LPS	lps	NN	NN	_	30	conj	_	_
38	.	.	.	.	_	5	punct	_	_

1	Sp	sp	NN	NN	_	3	compound	_	_
2	family	family	NN	NN	_	3	compound	_	_
3	members	member	NNS	NNS	_	5	nsubj	_	_
4	preferentially	preferentially	RB	RB	_	5	advmod	_	_
5	interact	interact	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	promoter	promoter	NN	NN	_	10	compound	_	_
9	proximal	proximal	JJ	JJ	_	10	amod	_	_
10	repeat	repeat	NN	NN	_	5	nmod	_	_
11	within	within	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	HTLV-I	htlv-i	NN	NN	_	14	compound	_	_
14	enhancer	enhancer	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	T	t	NN	NN	_	6	compound	_	_
3	cell	cell	NN	NN	_	6	compound	_	_
4	lymphotropic	lymphotropic	JJ	JJ	_	6	amod	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	11	nsubj	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	encodes	encode	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transactivator	transactivator	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	Tax	tax	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	facilitates	facilitate	VBZ	VBZ	_	14	acl:relcl	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	from	from	IN	IN	_	27	case	_	_
23	three	three	CD	CD	_	27	nummod	_	_
24	21	21	CD	CD	_	27	nummod	_	_
25	bp	bp	NN	NN	_	27	compound	_	_
26	repeated	repeated	JJ	JJ	_	27	amod	_	_
27	elements	element	NNS	NNS	_	21	nmod	_	_
28	within	within	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	U3	u3	NN	NN	_	31	compound	_	_
31	region	region	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	36	case	_	_
33	the	the	DT	DT	_	36	det	_	_
34	long	long	JJ	JJ	_	36	amod	_	_
35	terminal	terminal	JJ	JJ	_	36	amod	_	_
36	repeat	repeat	NN	NN	_	31	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	LTR	ltr	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	11	punct	_	_

1	Examination	examination	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	basal	basal	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	1	nmod	_	_
6	interacting	interact	VBG	VBG	_	5	acl	_	_
7	with	with	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	21	21	CD	CD	_	12	nummod	_	_
10	bp	bp	NN	NN	_	12	compound	_	_
11	repeat	repeat	NN	NN	_	12	compound	_	_
12	elements	element	NNS	NNS	_	6	nmod	_	_
13	through	through	IN	IN	_	20	case	_	_
14	electrophoretic	electrophoretic	JJ	JJ	_	16	amod	_	_
15	mobility	mobility	NN	NN	_	16	compound	_	_
16	shift	shift	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	EMS	ems	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	analyses	analysis	NNS	NNS	_	1	nmod	_	_
21	has	have	VBZ	VBZ	_	22	aux	_	_
22	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	formation	formation	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	DNA-protein	dna-protein	JJ	JJ	_	27	amod	_	_
27	complexes	complex	NNS	NNS	_	24	nmod	_	_
28	common	common	JJ	JJ	_	27	amod	_	_
29	to	to	TO	TO	_	30	case	_	_
30	each	each	DT	DT	_	28	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	21	21	CD	CD	_	35	nummod	_	_
34	bp	bp	NN	NN	_	35	compound	_	_
35	repeats	repeat	NNS	NNS	_	30	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	C1-C3	c1-c3	NN	NN	_	30	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	as	as	RB	RB	_	27	cc	_	_
40	well	well	RB	RB	_	39	mwe	_	_
41	as	as	IN	IN	_	39	mwe	_	_
42	three	three	CD	CD	_	44	nummod	_	_
43	DNA-protein	dna-protein	JJ	JJ	_	44	amod	_	_
44	complexes	complex	NNS	NNS	_	27	conj	_	_
45	specific	specific	JJ	JJ	_	44	amod	_	_
46	to	to	TO	TO	_	53	case	_	_
47	the	the	DT	DT	_	53	det	_	_
48	promoter	promoter	NN	NN	_	53	compound	_	_
49	proximal	proximal	JJ	JJ	_	53	amod	_	_
50	(	(	-LRB-	-LRB-	_	53	punct	_	_
51	pp	pp	NN	NN	_	53	compound	_	_
52	)	)	-RRB-	-RRB-	_	53	punct	_	_
53	repeat	repeat	NN	NN	_	45	nmod	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	U1	u1	NN	NN	_	53	dep	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	U1A/U1B	u1a/u1b	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	and	and	CC	CC	_	55	cc	_	_
60	U2	u2	NN	NN	_	55	conj	_	_
61	;	;	:	:	_	60	punct	_	_
62	1-4	1-4	CD	CD	_	60	dep	_	_
63	)	)	-RRB-	-RRB-	_	55	punct	_	_
64	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	indicated	indicate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	individual	individual	JJ	JJ	_	8	amod	_	_
8	repeats	repeat	NNS	NNS	_	11	nsubj	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	identical	identical	JJ	JJ	_	4	ccomp	_	_
12	with	with	IN	IN	_	13	case	_	_
13	respect	respect	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	21	nmod	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	interact	interact	VBP	VBP	_	17	acl:relcl	_	_
22	.	.	.	.	_	4	punct	_	_

1	EMS	ems	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	11	nsubj	_	_
3	utilizing	utilize	VBG	VBG	_	2	acl	_	_
4	a	a	DT	DT	_	5	det	_	_
5	series	series	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	mutated	mutate	VBN	VBN	_	10	amod	_	_
8	pp	pp	NN	NN	_	10	compound	_	_
9	repeat	repeat	NN	NN	_	10	compound	_	_
10	elements	element	NNS	NNS	_	5	nmod	_	_
11	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	26	mark	_	_
13	the	the	DT	DT	_	16	det	_	_
14	nucleotide	nucleotide	NN	NN	_	16	compound	_	_
15	sequence	sequence	NN	NN	_	16	compound	_	_
16	requirements	requirement	NNS	NNS	_	26	nsubj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	U1	u1	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	U1A/U1B	u1a/u1b	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	U2	u2	NN	NN	_	18	conj	_	_
24	formation	formation	NN	NN	_	18	dep	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	separable	separable	JJ	JJ	_	11	ccomp	_	_
27	from	from	IN	IN	_	28	case	_	_
28	those	those	DT	DT	_	26	nmod	_	_
29	required	require	VBN	VBN	_	28	acl	_	_
30	for	for	IN	IN	_	32	case	_	_
31	C1-C3	c1-c3	NN	NN	_	32	compound	_	_
32	formation	formation	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	Competition	competition	NN	NN	_	3	compound	_	_
2	EMS	ems	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	11	nsubj	_	_
4	utilizing	utilize	VBG	VBG	_	3	acl	_	_
5	Sp1	sp1	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CREB	creb	NN	NN	_	5	conj	_	_
8	binding	binding	NN	NN	_	10	compound	_	_
9	site	site	NN	NN	_	10	compound	_	_
10	oligonucleotides	oligonucleotide	NNS	NNS	_	5	dep	_	_
11	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	18	mark	_	_
13	Sp	sp	NN	NN	_	15	compound	_	_
14	family	family	NN	NN	_	15	compound	_	_
15	members	member	NNS	NNS	_	18	nsubj	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	components	component	NNS	NNS	_	11	ccomp	_	_
19	of	of	IN	IN	_	20	case	_	_
20	U1	u1	NN	NN	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	U1A/U1B	u1a/u1b	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	U2	u2	NN	NN	_	20	conj	_	_
26	and	and	CC	CC	_	18	cc	_	_
27	that	that	IN	IN	_	33	mark	_	_
28	ATF/CREB	atf/creb	NN	NN	_	30	compound	_	_
29	family	family	NN	NN	_	30	compound	_	_
30	members	member	NNS	NNS	_	33	nsubj	_	_
31	are	be	VBP	VBP	_	33	cop	_	_
32	critical	critical	JJ	JJ	_	33	amod	_	_
33	components	component	NNS	NNS	_	18	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	C1-C3	c1-c3	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	11	punct	_	_

1	EMS	ems	NN	NN	_	3	compound	_	_
2	supershift	supershift	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Sp1	sp1	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	5	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	U1A	u1a	NN	NN	_	12	compound	_	_
12	formation	formation	NN	NN	_	9	nmod	_	_
13	while	while	IN	IN	_	16	mark	_	_
14	Sp3	sp3	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	9	advcl	_	_
17	in	in	IN	IN	_	18	case	_	_
18	U1B	u1b	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	U2	u2	NN	NN	_	18	conj	_	_
21	formation	formation	NN	NN	_	18	dep	_	_
22	.	.	.	.	_	5	punct	_	_

1	EMS	ems	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	17	nsubj	_	_
3	performed	perform	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	extracts	extract	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	10	case	_	_
8	Tax-expressing	tax-expressing	JJ	JJ	_	10	amod	_	_
9	Jurkat	jurkat	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	16	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	10	conj	_	_
17	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	Tax	tax	NN	NN	_	20	nsubj	_	_
20	prevents	prevent	VBZ	VBZ	_	17	ccomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	formation	formation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	U1	u1	NN	NN	_	22	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	U1A/U1B	u1a/u1b	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	U2	u2	NN	NN	_	24	conj	_	_
30	DNA-protein	dna-protein	JJ	JJ	_	31	amod	_	_
31	complexes	complex	NNS	NNS	_	24	dep	_	_
32	.	.	.	.	_	17	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Tax	tax	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	Sp	sp	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	members	member	NNS	NNS	_	8	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	pp	pp	NN	NN	_	16	compound	_	_
16	repeat	repeat	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	observations	observation	NNS	NNS	_	8	advcl	_	_
5	,	,	,	,	_	8	punct	_	_
6	it	it	PRP	PRP	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	possible	possible	JJ	JJ	_	0	root	_	_
9	that	that	IN	IN	_	28	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	interaction	interaction	NN	NN	_	28	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Sp	sp	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ATF/CREB	atf/creb	NN	NN	_	17	compound	_	_
16	family	family	NN	NN	_	17	compound	_	_
17	members	member	NNS	NNS	_	13	conj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	pp	pp	NN	NN	_	21	compound	_	_
21	repeat	repeat	NN	NN	_	11	nmod	_	_
22	during	during	IN	IN	_	23	case	_	_
23	basal	basal	JJ	JJ	_	11	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Tax-mediated	tax-mediated	JJ	JJ	_	23	conj	_	_
26	transcription	transcription	NN	NN	_	23	dep	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	play	play	VB	VB	_	8	ccomp	_	_
29	a	a	DT	DT	_	31	det	_	_
30	critical	critical	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	viral	viral	JJ	JJ	_	35	amod	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	28	nmod	_	_
36	during	during	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	initial	initial	JJ	JJ	_	39	amod	_	_
39	stages	stage	NNS	NNS	_	28	nmod	_	_
40	of	of	IN	IN	_	42	case	_	_
41	virus	virus	NN	NN	_	42	compound	_	_
42	infection	infection	NN	NN	_	39	nmod	_	_
43	or	or	CC	CC	_	39	cc	_	_
44	during	during	IN	IN	_	45	case	_	_
45	activation	activation	NN	NN	_	39	conj	_	_
46	of	of	IN	IN	_	49	case	_	_
47	a	a	DT	DT	_	49	det	_	_
48	latent	latent	JJ	JJ	_	49	amod	_	_
49	infection	infection	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytoplasmic	cytoplasmic	JJ	JJ	_	3	amod	_	_
3	domain	domain	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	13	case	_	_
5	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	13	amod	_	_
6	colony-stimulating	colony-stimulating	JJ	JJ	_	13	amod	_	_
7	factor	factor	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	GM-CSF	gm-csf	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	alpha	alpha	NN	NN	_	13	compound	_	_
13	subunit	subunit	NN	NN	_	3	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	essential	essential	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	19	case	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	GM-CSF-mediated	gm-csf-mediated	JJ	JJ	_	19	dep	_	_
19	growth	growth	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	differentiation	differentiation	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	15	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	regulates	regulate	VBZ	VBZ	_	0	root	_	_
8	differentiation	differentiation	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	survival	survival	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	proliferation	proliferation	NN	NN	_	8	conj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	colony-forming	colony-forming	JJ	JJ	_	18	amod	_	_
16	unit-granulocyte-macrophage	unit-granulocyte-macrophage	JJ	JJ	_	18	amod	_	_
17	progenitor	progenitor	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	8	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biologic	biologic	JJ	JJ	_	3	amod	_	_
3	actions	action	NNS	NNS	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	binding	bind	VBG	VBG	_	7	advcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	consisting	consist	VBG	VBG	_	13	acl	_	_
15	of	of	IN	IN	_	17	case	_	_
16	two	two	CD	CD	_	17	nummod	_	_
17	chains	chain	NNS	NNS	_	14	nmod	_	_
18	designated	designate	VBN	VBN	_	17	acl	_	_
19	as	as	IN	IN	_	20	case	_	_
20	alpha	alpha	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	beta	beta	NN	NN	_	20	conj	_	_
23	subunits	subunit	NNS	NNS	_	20	dep	_	_
24	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	28	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	murine	murine	JJ	JJ	_	9	amod	_	_
7	FDC-P1-derived	fdc-p1-derived	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	28	nsubjpass	_	_
10	WT-19	wt-19	NN	NN	_	9	dep	_	_
11	transfected	transfect	VBN	VBN	_	9	acl	_	_
12	with	with	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	GM-CSF	gm-csf	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	11	nmod	_	_
17	alpha	alpha	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	beta	beta	NN	NN	_	16	conj	_	_
20	subunits	subunit	NNS	NNS	_	16	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	GM-CSFRalpha	gm-csfralpha	NN	NN	_	16	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	beta	beta	NN	NN	_	22	conj	_	_
25	)	)	-RRB-	-RRB-	_	22	punct	_	_
26	can	can	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	induced	induce	VBN	VBN	_	3	ccomp	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	differentiate	differentiate	VB	VB	_	28	xcomp	_	_
31	by	by	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	addition	addition	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	human	human	JJ	JJ	_	36	amod	_	_
36	GM-CSF	gm-csf	NN	NN	_	33	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	hGM-CSF	hgm-csf	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	expressing	express	VBG	VBG	_	14	advcl	_	_
3	a	a	DT	DT	_	4	det	_	_
4	series	series	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	GM-CSFRalpha	gm-csfralpha	NN	NN	_	7	compound	_	_
7	mutants	mutant	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	WT19	wt19	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	determined	determine	VBN	VBN	_	0	root	_	_
15	the	the	DT	DT	_	18	det	_	_
16	amino	amino	NN	NN	_	18	compound	_	_
17	acid	acid	NN	NN	_	18	compound	_	_
18	domains	domain	NNS	NNS	_	14	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	GM-CSFRalpha	gm-csfralpha	NN	NN	_	18	nmod	_	_
22	cytoplasmic	cytoplasmic	JJ	JJ	_	23	amod	_	_
23	domain	domain	NN	NN	_	21	dep	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	regulate	regulate	VBP	VBP	_	18	acl:relcl	_	_
26	cell	cell	NN	NN	_	25	dobj	_	_
27	differentiation	differentiation	NN	NN	_	26	dep	_	_
28	,	,	,	,	_	26	punct	_	_
29	proliferation	proliferation	NN	NN	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	survival	survival	NN	NN	_	26	conj	_	_
33	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	the	the	DT	DT	_	8	det	_	_
5	membrane	membrane	NN	NN	_	8	compound	_	_
6	proximal	proximal	JJ	JJ	_	8	amod	_	_
7	proline-rich	proline-rich	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	14	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	adjacent	adjacent	JJ	JJ	_	12	amod	_	_
11	16	16	CD	CD	_	12	nummod	_	_
12	residues	residue	NNS	NNS	_	8	conj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	essential	essential	JJ	JJ	_	2	ccomp	_	_
15	for	for	IN	IN	_	18	case	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	hGM-CSF-dependent	hgm-csf-dependent	JJ	JJ	_	18	dep	_	_
18	cell	cell	NN	NN	_	14	nmod	_	_
19	proliferation	proliferation	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	differentiation	differentiation	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	C-terminal	c-terminal	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	GM-CSFRalpha	gm-csfralpha	NN	NN	_	11	compound	_	_
10	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
11	domain	domain	NN	NN	_	6	nmod	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	necessary	necessary	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	17	case	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	differentiation	differentiation	NN	NN	_	14	nmod	_	_
18	mediated	mediate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	hGM-CSF	hgm-csf	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	but	but	CC	CC	_	14	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	removal	removal	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	region	region	NN	NN	_	24	nmod	_	_
28	severely	severely	RB	RB	_	29	advmod	_	_
29	impaired	impair	VBD	VBD	_	14	conj	_	_
30	the	the	DT	DT	_	31	det	_	_
31	ability	ability	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	hGM-CSF	hgm-csf	NN	NN	_	31	nmod	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	support	support	VB	VB	_	31	acl	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	survival	survival	NN	NN	_	35	dobj	_	_
38	.	.	.	.	_	14	punct	_	_

1	While	while	IN	IN	_	14	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	activation	activation	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	JAK2	jak2	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	Shc	shc	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	Erk	erk	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	STAT5	stat5	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	5	conj	_	_
14	correlated	correlate	VBD	VBD	_	22	advcl	_	_
15	with	with	IN	IN	_	18	case	_	_
16	hGM-CSF-mediated	hgm-csf-mediated	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	growth	growth	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	22	nsubj	_	_
22	occurred	occur	VBD	VBD	_	0	root	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	absence	absence	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	activation	activation	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	these	these	DT	DT	_	32	det	_	_
30	signal	signal	NN	NN	_	32	compound	_	_
31	transduction	transduction	NN	NN	_	32	compound	_	_
32	pathways	pathway	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	gamma-Interferon-induced	gamma-interferon-induced	JJ	JJ	_	2	amod	_	_
2	resistance	resistance	NN	NN	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	1,25-(OH)2	1,25-(oh)2	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	macrophages	macrophage	NNS	NNS	_	8	conj	_	_
11	:	:	:	:	_	2	punct	_	_
12	a	a	DT	DT	_	13	det	_	_
13	mechanism	mechanism	NN	NN	_	2	dep	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	hypercalcemia	hypercalcemia	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	granulomatoses	granulomatose	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	hypercalcemia	hypercalcemia	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	various	various	JJ	JJ	_	5	amod	_	_
5	granulomatoses	granulomatose	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	caused	cause	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	15	case	_	_
9	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
10	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	11	compound	_	_
11	D	d	NN	NN	_	15	compound	_	_
12	-LSB-	-lsb-	-LRB-	-LRB-	_	13	punct	_	_
13	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	11	appos	_	_
14	-RSB-	-rsb-	-RRB-	-RRB-	_	13	punct	_	_
15	overproduction	overproduction	NN	NN	_	7	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	disease-activated	disease-activated	JJ	JJ	_	18	amod	_	_
18	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inability	inability	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	suppress	suppress	VB	VB	_	2	acl	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	synthesis	synthesis	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
11	contrasts	contrast	VBZ	VBZ	_	0	root	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	tight	tight	JJ	JJ	_	15	amod	_	_
15	control	control	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	production	production	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	macrophage	macrophage	NN	NN	_	21	compound	_	_
21	precursors	precursor	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
24	blood	blood	NN	NN	_	25	compound	_	_
25	monocytes	monocyte	NNS	NNS	_	21	appos	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	PBM	pbm	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	compound	_	_
5	resistance	resistance	NN	NN	_	6	nsubj	_	_
6	develops	develop	VBZ	VBZ	_	2	ccomp	_	_
7	as	as	IN	IN	_	9	mark	_	_
8	PBM	pbm	NNS	NNS	_	9	nsubj	_	_
9	differentiate	differentiate	VBP	VBP	_	6	dep	_	_
10	to	to	TO	TO	_	11	case	_	_
11	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
12	or	or	CC	CC	_	9	cc	_	_
13	with	with	IN	IN	_	15	case	_	_
14	macrophage	macrophage	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	9	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Normal	normal	JJ	JJ	_	5	amod	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	pulmonary	pulmonary	JJ	JJ	_	5	amod	_	_
4	alveolar	alveolar	JJ	JJ	_	5	amod	_	_
5	macrophages	macrophage	NNS	NNS	_	11	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PAM	pam	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	less	less	RBR	RBR	_	11	advmod	_	_
11	sensitive	sensitive	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	nmod	_	_
14	than	than	IN	IN	_	15	case	_	_
15	PBM	pbm	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	despite	despite	IN	IN	_	22	case	_	_
18	similar	similar	JJ	JJ	_	22	amod	_	_
19	vitamin	vitamin	NN	NN	_	21	compound	_	_
20	D	d	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	content	content	NN	NN	_	11	nmod	_	_
23	;	;	:	:	_	11	punct	_	_
24	however	however	RB	RB	_	30	advmod	_	_
25	,	,	,	,	_	30	punct	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	PBM	pbm	NNS	NNS	_	30	nsubj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	PAM	pam	NNS	NNS	_	27	conj	_	_
30	respond	respond	VBP	VBP	_	11	parataxis	_	_
31	to	to	TO	TO	_	33	case	_	_
32	exogenous	exogenous	JJ	JJ	_	33	amod	_	_
33	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	30	nmod	_	_
34	by	by	IN	IN	_	35	mark	_	_
35	inhibiting	inhibit	VBG	VBG	_	30	advcl	_	_
36	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	37	compound	_	_
37	synthesis	synthesis	NN	NN	_	35	dobj	_	_
38	and	and	CC	CC	_	35	cc	_	_
39	inducing	induce	VBG	VBG	_	35	conj	_	_
40	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	41	compound	_	_
41	degradation	degradation	NN	NN	_	39	dobj	_	_
42	through	through	IN	IN	_	43	case	_	_
43	enhancement	enhancement	NN	NN	_	35	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	24-hydroxylase	24-hydroxylase	NN	NN	_	46	compound	_	_
46	mRNA	mrna	NN	NN	_	43	nmod	_	_
47	levels	level	NNS	NNS	_	46	dep	_	_
48	and	and	CC	CC	_	46	cc	_	_
49	activity	activity	NN	NN	_	46	conj	_	_
50	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	monocytic	monocytic	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	7	nsubj	_	_
6	THP-1	thp-1	NN	NN	_	5	dep	_	_
7	mimics	mimic	VBZ	VBZ	_	0	root	_	_
8	PAM	pam	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sensitivity	sensitivity	NN	NN	_	11	conj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	exogenous	exogenous	JJ	JJ	_	16	amod	_	_
16	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	utilized	utilize	VBD	VBD	_	0	root	_	_
3	THP-1	thp-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	2	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	examine	examine	VB	VB	_	2	advcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	response	response	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	macrophage	macrophage	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	THP-1	thp-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	gamma-interferon	gamma-interferon	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	gamma-IFN	gamma-ifn	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	enhances	enhance	VBZ	VBZ	_	0	root	_	_
11	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	10	iobj	_	_
13	30-fold	30-fold	RB	RB	_	10	dobj	_	_
14	,	,	,	,	_	10	punct	_	_
15	blocks	block	VBZ	VBZ	_	10	conj	_	_
16	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	17	compound	_	_
17	suppression	suppression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	synthesis	synthesis	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	reduces	reduce	VBZ	VBZ	_	10	conj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	42.2	42.2	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	23	nmod	_	_
27	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	28	compound	_	_
28	induction	induction	NN	NN	_	23	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
31	degradation	degradation	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	antagonistic	antagonistic	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	gamma-IFN	gamma-ifn	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	9	cop	_	_
7	not	not	RB	RB	_	9	neg	_	_
8	merely	merely	RB	RB	_	9	advmod	_	_
9	restricted	restricted	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	enzymatic	enzymatic	JJ	JJ	_	12	amod	_	_
12	activities	activity	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	THP-1	thp-1	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	in	in	IN	IN	_	7	case	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	PBM	pbm	NNS	NNS	_	3	conj	_	_
8	,	,	,	,	_	10	punct	_	_
9	gamma-IFN	gamma-ifn	NN	NN	_	10	nsubj	_	_
10	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
11	1,25-(OH)2D3	1,25-(oh)2d3	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	24-hydroxylase	24-hydroxylase	NN	NN	_	16	compound	_	_
15	mRNA	mrna	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	12	nmod	_	_
17	without	without	IN	IN	_	18	mark	_	_
18	reducing	reduce	VBG	VBG	_	10	advcl	_	_
19	mRNA	mrna	NN	NN	_	20	compound	_	_
20	stability	stability	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	10	punct	_	_
22	suggesting	suggest	VBG	VBG	_	10	advcl	_	_
23	gamma-IFN	gamma-ifn	NN	NN	_	24	compound	_	_
24	inhibition	inhibition	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	28	compound	_	_
27	transactivating	transactivating	NN	NN	_	28	compound	_	_
28	function	function	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	explain	explain	VBP	VBP	_	0	root	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	5	compound	_	_
5	overproduction	overproduction	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	granulomatoses	granulomatose	NNS	NNS	_	5	nmod	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	demonstrate	demonstrate	VBP	VBP	_	3	conj	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	gamma-IFN	gamma-ifn	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	16	compound	_	_
16	action	action	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interferons	interferon	NNS	NNS	_	2	nsubj	_	_
2	up-regulate	up-regulate	VBP	VBP	_	0	root	_	_
3	STAT1	stat1	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	STAT2	stat2	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	IRF	irf	NN	NN	_	11	compound	_	_
9	family	family	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	3	conj	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	3	dep	_	_
14	in	in	IN	IN	_	19	case	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	mononuclear	mononuclear	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	3	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	macrophages	macrophage	NNS	NNS	_	19	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	IFN	ifn	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	binding	binding	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IFNs	ifn	NNS	NNS	_	6	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	receptors	receptor	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	6	conj	_	_
15	of	of	IN	IN	_	24	case	_	_
16	Janus	janus	NN	NN	_	18	compound	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	kinase	kinase	NN	NN	_	24	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	JAK	jak	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	-STAT	-stat	JJ	JJ	_	24	amod	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	IFN-alpha	ifn-alpha	NN	NN	_	1	nmod	_	_
6	leads	lead	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	assembly	assembly	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	17	case	_	_
11	IFN-stimulated	ifn-stimulated	JJ	JJ	_	17	amod	_	_
12	gene	gene	NN	NN	_	17	compound	_	_
13	factor	factor	NN	NN	_	17	compound	_	_
14	3	3	CD	CD	_	17	nummod	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	9	nmod	_	_
18	formed	form	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	STAT1	stat1	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	STAT2	stat2	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	p48	p48	NN	NN	_	26	compound	_	_
26	protein	protein	NN	NN	_	20	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	homodimeric	homodimeric	JJ	JJ	_	8	amod	_	_
7	STAT1	stat1	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	these	these	DT	DT	_	4	det	_	_
3	signaling	signal	VBG	VBG	_	4	amod	_	_
4	molecules	molecule	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	10	advcl	_	_
7	constitutively	constitutively	RB	RB	_	6	advmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	there	there	EX	EX	_	10	expl	_	_
10	is	be	VBZ	VBZ	_	0	root	_	_
11	also	also	RB	RB	_	10	advmod	_	_
12	evidence	evidence	NN	NN	_	10	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	regulation	regulation	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IFNs	ifn	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	characterized	characterize	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	17	case	_	_
7	STAT	stat	NN	NN	_	17	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IFN	ifn	NN	NN	_	7	conj	_	_
10	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
11	factor	factor	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	IRF	irf	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	family	family	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	5	nmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	primary	primary	JJ	JJ	_	23	amod	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	5	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	macrophages	macrophage	NNS	NNS	_	23	conj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	5	nmod	_	_
28	to	to	TO	TO	_	29	case	_	_
29	IFN-alpha	ifn-alpha	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	IFN-gamma	ifn-gamma	NN	NN	_	29	conj	_	_
32	stimulation	stimulation	NN	NN	_	29	dep	_	_
33	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	IFN-alpha	ifn-alpha	NN	NN	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	4	conj	_	_
7	rapidly	rapidly	RB	RB	_	8	advmod	_	_
8	and	and	CC	CC	_	10	advmod	_	_
9	efficiently	efficiently	RB	RB	_	8	advmod	_	_
10	enhanced	enhance	VBD	VBD	_	2	ccomp	_	_
11	STAT1	stat1	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	STAT2	stat2	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	p48	p48	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	IRF-1	irf-1	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	11	conj	_	_
20	expression	expression	NN	NN	_	11	dep	_	_
21	.	.	.	.	_	2	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	IRF-1	irf-1	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	strongly	strongly	RB	RB	_	2	advmod	_	_
8	than	than	IN	IN	_	9	mark	_	_
9	IFN-alpha	ifn-alpha	NN	NN	_	7	advcl	_	_
10	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	13	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	synthesis	synthesis	NN	NN	_	9	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	cycloheximide	cycloheximide	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	2	punct	_	_
13	suggested	suggest	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	these	these	DT	DT	_	16	det	_	_
16	genes	gene	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	13	ccomp	_	_
19	directly	directly	RB	RB	_	21	advmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	IFNs	ifn	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	IRF-2	irf-2	NN	NN	_	2	compound	_	_
2	gene	gene	NN	NN	_	7	nsubj	_	_
3	was	be	VBD	VBD	_	7	cop	_	_
4	apparently	apparently	RB	RB	_	7	advmod	_	_
5	only	only	RB	RB	_	6	advmod	_	_
6	weakly	weakly	RB	RB	_	7	advmod	_	_
7	responsive	responsive	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	case	_	_
9	IFNs	ifn	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	macrophages	macrophage	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	pretreated	pretreated	JJ	JJ	_	25	advcl	_	_
5	with	with	IN	IN	_	7	case	_	_
6	low	low	JJ	JJ	_	7	amod	_	_
7	doses	dose	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	then	then	RB	RB	_	4	advmod	_	_
12	stimulated	stimulate	VBN	VBN	_	4	conj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	IFN-alpha	ifn-alpha	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	25	punct	_	_
16	clearly	clearly	RB	RB	_	17	advmod	_	_
17	enhanced	enhance	VBN	VBN	_	18	amod	_	_
18	formation	formation	NN	NN	_	25	nsubjpass	_	_
19	of	of	IN	IN	_	23	case	_	_
20	specific	specific	JJ	JJ	_	23	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	complexes	complex	NNS	NNS	_	18	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	detected	detect	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	higher	higher	JJR	JJR	_	6	amod	_	_
5	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	16	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT1	stat1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	STAT2	stat2	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	p48	p48	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	conj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	result	result	VB	VB	_	2	ccomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	enhanced	enhance	VBN	VBN	_	20	amod	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	transduction	transduction	NN	NN	_	16	nmod	_	_
21	for	for	IN	IN	_	22	case	_	_
22	cytokines	cytokine	NNS	NNS	_	20	nmod	_	_
23	utilizing	utilize	VBG	VBG	_	20	acl	_	_
24	these	these	DT	DT	_	26	det	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	dobj	_	_
27	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ascorbate	ascorbate	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	12	case	_	_
10	tumour	tumour	NN	NN	_	12	compound	_	_
11	necrosis	necrosis	NN	NN	_	12	compound	_	_
12	factor-alpha	factor-alpha	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	T-cells	t-cell	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	product	product	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	ascorbate	ascorbate	NN	NN	_	6	compound	_	_
6	oxidation	oxidation	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	ascorbate	ascorbate	NN	NN	_	11	compound	_	_
10	free	free	JJ	JJ	_	11	amod	_	_
11	radical	radical	NN	NN	_	3	appos	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	AFR	afr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	3	punct	_	_
16	acts	act	VBZ	VBZ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	biological	biological	JJ	JJ	_	19	amod	_	_
19	systems	system	NNS	NNS	_	16	nmod	_	_
20	mainly	mainly	RB	RB	_	23	advmod	_	_
21	as	as	IN	IN	_	23	case	_	_
22	an	a	DT	DT	_	23	det	_	_
23	oxidant	oxidant	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	16	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	through	through	IN	IN	_	28	case	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	role	role	NN	NN	_	16	conj	_	_
29	in	in	IN	IN	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	plasma	plasma	NN	NN	_	34	compound	_	_
32	membrane	membrane	NN	NN	_	34	compound	_	_
33	redox	redox	NN	NN	_	34	compound	_	_
34	system	system	NN	NN	_	28	nmod	_	_
35	exerts	exert	VBZ	VBZ	_	16	dep	_	_
36	different	different	JJ	JJ	_	37	amod	_	_
37	effects	effect	NNS	NNS	_	35	dobj	_	_
38	on	on	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	cell	cell	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ascorbate	ascorbate	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	AFR	afr	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	dehydroascorbate	dehydroascorbate	NN	NN	_	7	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	DHA	dha	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	Jurkat	jurkat	NN	NN	_	25	compound	_	_
25	T-cells	t-cell	NNS	NNS	_	17	nmod	_	_
26	stimulated	stimulate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	30	case	_	_
28	tumour	tumour	NN	NN	_	30	compound	_	_
29	necrosis	necrosis	NN	NN	_	30	compound	_	_
30	factor-alpha	factor-alpha	NN	NN	_	26	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	TNF-alpha	tnf-alpha	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	by	by	IN	IN	_	9	case	_	_
6	electrophoretic	electrophoretic	JJ	JJ	_	9	amod	_	_
7	mobility	mobility	NN	NN	_	9	compound	_	_
8	shift	shift	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	that	that	IN	IN	_	13	mark	_	_
12	ascorbate	ascorbate	NN	NN	_	13	nsubj	_	_
13	increases	increase	VBZ	VBZ	_	3	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	DNA	dna	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	TNF-alpha-stimulated	tnf-alpha-stimulated	JJ	JJ	_	23	amod	_	_
22	Jurkat	jurkat	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ascorbate	ascorbate	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	enhance	enhance	VB	VB	_	2	acl	_	_
7	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
8	inhibitory	inhibitory	JJ	JJ	_	7	dep	_	_
9	IkBalpha	ikbalpha	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	degradation	degradation	NN	NN	_	6	dobj	_	_
12	correlates	correlate	VBZ	VBZ	_	0	root	_	_
13	completely	completely	RB	RB	_	12	advmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	capacity	capacity	NN	NN	_	12	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	induce	induce	VB	VB	_	16	dep	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	18	dobj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	DNA	dna	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	potentiate	potentiate	VB	VB	_	18	conj	_	_
26	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	27	amod	_	_
27	transactivation	transactivation	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	34	case	_	_
29	the	the	DT	DT	_	34	det	_	_
30	HIV-1	hiv-1	NN	NN	_	34	compound	_	_
31	long	long	JJ	JJ	_	34	amod	_	_
32	terminal	terminal	JJ	JJ	_	34	amod	_	_
33	repeat	repeat	NN	NN	_	34	compound	_	_
34	promoter	promoter	NN	NN	_	27	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	TNF-alpha-stimulated	tnf-alpha-stimulated	JJ	JJ	_	38	amod	_	_
37	Jurkat	jurkat	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	27	nmod	_	_
39	but	but	CC	CC	_	38	cc	_	_
40	not	not	RB	RB	_	42	neg	_	_
41	in	in	IN	IN	_	42	case	_	_
42	cells	cell	NNS	NNS	_	38	conj	_	_
43	stimulated	stimulate	VBN	VBN	_	42	acl	_	_
44	with	with	IN	IN	_	45	case	_	_
45	PMA	pma	NN	NN	_	43	nmod	_	_
46	plus	plus	CC	CC	_	45	cc	_	_
47	ionomycin	ionomycin	NN	NN	_	45	conj	_	_
48	.	.	.	.	_	12	punct	_	_

1	AFR	afr	NN	NN	_	2	nsubj	_	_
2	behaves	behave	VBZ	VBZ	_	0	root	_	_
3	like	like	IN	IN	_	4	case	_	_
4	ascorbate	ascorbate	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	while	while	IN	IN	_	13	mark	_	_
7	DHA	dha	NN	NN	_	13	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ascorbate	ascorbate	NN	NN	_	10	compound	_	_
10	phosphate	phosphate	NN	NN	_	7	conj	_	_
11	do	do	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affect	affect	VB	VB	_	2	advcl	_	_
14	TNF-alpha-mediated	tnf-alpha-mediated	JJ	JJ	_	16	amod	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	possible	possible	JJ	JJ	_	9	amod	_	_
9	relationship	relationship	NN	NN	_	5	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	electron-transport	electron-transport	JJ	JJ	_	16	amod	_	_
16	system	system	NN	NN	_	12	nmod	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	membrane	membrane	NN	NN	_	12	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	ascorbate	ascorbate	NN	NN	_	12	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	free	free	JJ	JJ	_	26	amod	_	_
26	radical	radical	NN	NN	_	22	conj	_	_
27	and	and	CC	CC	_	12	cc	_	_
28	redox-dependent	redox-dependent	JJ	JJ	_	30	amod	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	12	conj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	T-cells	t-cell	NNS	NNS	_	30	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	RP1	rp1	NN	NN	_	17	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	member	member	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	adenomatous	adenomatous	JJ	JJ	_	13	amod	_	_
9	polyposis	polyposis	NN	NN	_	13	compound	_	_
10	coli-binding	coli-binding	JJ	JJ	_	13	amod	_	_
11	EB1-like	eb1-like	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	differentially	differentially	RB	RB	_	17	advmod	_	_
17	expressed	express	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	CD3	cd3	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	CD28	cd28	NN	NN	_	4	conj	_	_
7	molecules	molecule	NNS	NNS	_	4	dep	_	_
8	on	on	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
11	represents	represent	VBZ	VBZ	_	0	root	_	_
12	one	one	CD	CD	_	11	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	most	most	RBS	RBS	_	16	advmod	_	_
16	effective	effective	JJ	JJ	_	17	amod	_	_
17	signals	signal	NNS	NNS	_	12	nmod	_	_
18	for	for	IN	IN	_	21	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocyte	lymphocyte	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	11	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	triggering	triggering	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
26	cytotoxic	cytotoxic	JJ	JJ	_	28	amod	_	_
27	effector	effector	NN	NN	_	28	compound	_	_
28	function	function	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	0	root	_	_
3	genes	gene	NNS	NNS	_	2	dobj	_	_
4	that	that	WDT	WDT	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	3	acl:relcl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	after	after	IN	IN	_	11	case	_	_
11	stimulation	stimulation	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	mRNA	mrna	NN	NN	_	33	nsubjpass	_	_
14	from	from	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	that	that	WDT	WDT	_	20	nsubjpass	_	_
18	had	have	VBD	VBD	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	activated	activate	VBN	VBN	_	16	acl:relcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	simultaneous	simultaneous	JJ	JJ	_	24	amod	_	_
24	stimulation	stimulation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	CD3	cd3	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD28	cd28	NN	NN	_	27	conj	_	_
30	trigger	trigger	NN	NN	_	31	compound	_	_
31	molecules	molecule	NNS	NNS	_	27	dep	_	_
32	was	be	VBD	VBD	_	33	auxpass	_	_
33	transcribed	transcribe	VBN	VBN	_	2	parataxis	_	_
34	for	for	IN	IN	_	39	case	_	_
35	a	a	DT	DT	_	39	det	_	_
36	differential	differential	JJ	JJ	_	39	amod	_	_
37	mRNA	mrna	NN	NN	_	39	compound	_	_
38	display	display	NN	NN	_	39	compound	_	_
39	analysis	analysis	NN	NN	_	33	nmod	_	_
40	into	into	IN	IN	_	41	case	_	_
41	cDNA	cdna	NN	NN	_	33	nmod	_	_
42	and	and	CC	CC	_	33	cc	_	_
43	was	be	VBD	VBD	_	44	auxpass	_	_
44	compared	compare	VBN	VBN	_	33	conj	_	_
45	with	with	IN	IN	_	46	case	_	_
46	cDNA	cdna	NN	NN	_	44	nmod	_	_
47	from	from	IN	IN	_	48	case	_	_
48	CD28-	cd28-	NN	NN	_	46	nmod	_	_
49	or	or	CC	CC	_	48	cc	_	_
50	CD3-activated	cd3-activated	JJ	JJ	_	48	conj	_	_
51	or	or	CC	CC	_	48	cc	_	_
52	resting	rest	VBG	VBG	_	48	conj	_	_
53	lymphocytes	lymphocyte	NNS	NNS	_	48	dep	_	_
54	.	.	.	.	_	2	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	confirmed	confirm	VBN	VBN	_	0	root	_	_
5	subsequently	subsequently	RB	RB	_	4	advmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	Northern	northern	NN	NN	_	9	compound	_	_
8	blot	blot	NN	NN	_	9	compound	_	_
9	analysis	analysis	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	fragments	fragment	NNS	NNS	_	1	nmod	_	_
6	expressed	express	VBN	VBN	_	5	acl	_	_
7	specifically	specifically	RB	RB	_	9	advmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	CD3-	cd3-	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CD28-activated	cd28-activated	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	designated	designate	VBN	VBN	_	0	root	_	_
16	RP1	rp1	NN	NN	_	15	xcomp	_	_
17	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	predictive	predictive	JJ	JJ	_	4	amod	_	_
3	protein-coding	protein-coding	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	RP1	rp1	NN	NN	_	4	nmod	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	homology	homology	NN	NN	_	7	dobj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	members	member	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	26	case	_	_
14	the	the	DT	DT	_	26	det	_	_
15	recently	recently	RB	RB	_	16	advmod	_	_
16	found	find	VBN	VBN	_	26	amod	_	_
17	adenomatous	adenomatous	JJ	JJ	_	26	amod	_	_
18	polyposis	polyposis	NN	NN	_	26	compound	_	_
19	coli	coli	NN	NN	_	26	compound	_	_
20	(	(	-LRB-	-LRB-	_	26	punct	_	_
21	APC	apc	NN	NN	_	26	compound	_	_
22	)	)	-RRB-	-RRB-	_	26	punct	_	_
23	protein-binding	protein-binding	JJ	JJ	_	26	amod	_	_
24	EB1	eb1	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	family	family	NN	NN	_	12	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	codes	code	VBZ	VBZ	_	26	acl:relcl	_	_
30	for	for	IN	IN	_	35	case	_	_
31	yet	yet	RB	RB	_	32	advmod	_	_
32	unknown	unknown	JJ	JJ	_	35	amod	_	_
33	protein	protein	NN	NN	_	35	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	s	s	NNS	NNS	_	29	nmod	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	7	punct	_	_

1	Bacterially	bacterially	RB	RB	_	2	advmod	_	_
2	expressed	express	VBN	VBN	_	4	amod	_	_
3	RP1	rp1	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	specific	specific	JJ	JJ	_	7	amod	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	case	_	_
9	wild-type	wild-type	JJ	JJ	_	7	nmod	_	_
10	but	but	CC	CC	_	9	cc	_	_
11	not	not	RB	RB	_	15	neg	_	_
12	to	to	TO	TO	_	15	case	_	_
13	mutated	mutate	VBN	VBN	_	15	amod	_	_
14	APC	apc	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	9	conj	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	rapid	rapid	JJ	JJ	_	3	amod	_	_
3	up-regulation	up-regulation	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	RP1	rp1	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	properly	properly	RB	RB	_	11	advmod	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	suggests	suggest	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	this	this	DT	DT	_	15	det	_	_
15	gene	gene	NN	NN	_	17	nsubj	_	_
16	might	might	MD	MD	_	17	aux	_	_
17	belong	belong	VB	VB	_	12	ccomp	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	immediate/early	immediate/early	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	family	family	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	controls	control	VBZ	VBZ	_	22	acl:relcl	_	_
26	the	the	DT	DT	_	29	det	_	_
27	signal	signal	NN	NN	_	29	compound	_	_
28	transduction	transduction	NN	NN	_	29	compound	_	_
29	cascade	cascade	NN	NN	_	25	dobj	_	_
30	downstream	downstream	RB	RB	_	29	advmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	TCR	tcr	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	12	punct	_	_

1	As	as	IN	IN	_	20	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	level	level	NN	NN	_	20	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	RP1	rp1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	activated	activate	VBN	VBN	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	a	a	DT	DT	_	15	det	_	_
15	spectrum	spectrum	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	tumor-derived	tumor-derived	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	15	nmod	_	_
20	correlates	correlate	VBZ	VBZ	_	35	advcl	_	_
21	with	with	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	proliferative	proliferative	JJ	JJ	_	24	amod	_	_
24	status	status	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	35	punct	_	_
29	members	member	NNS	NNS	_	35	nsubj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	EB1-like	eb1-like	JJ	JJ	_	34	amod	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	family	family	NN	NN	_	29	nmod	_	_
35	may	may	MD	MD	_	0	root	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	only	only	RB	RB	_	35	dep	_	_
38	be	be	VB	VB	_	39	auxpass	_	_
39	involved	involve	VBN	VBN	_	35	conj	_	_
40	in	in	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	tumorigenesis	tumorigenesis	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	colorectal	colorectal	JJ	JJ	_	45	amod	_	_
45	cancers	cancer	NNS	NNS	_	42	nmod	_	_
46	but	but	CC	CC	_	35	cc	_	_
47	may	may	MD	MD	_	49	aux	_	_
48	also	also	RB	RB	_	49	advmod	_	_
49	play	play	VB	VB	_	35	conj	_	_
50	a	a	DT	DT	_	51	det	_	_
51	role	role	NN	NN	_	49	dobj	_	_
52	in	in	IN	IN	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	proliferative	proliferative	JJ	JJ	_	55	amod	_	_
55	control	control	NN	NN	_	49	nmod	_	_
56	of	of	IN	IN	_	58	case	_	_
57	normal	normal	JJ	JJ	_	58	amod	_	_
58	cells	cell	NNS	NNS	_	55	nmod	_	_
59	.	.	.	.	_	35	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Rel	rel	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	Fos	fos	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	Jun	jun	NN	NN	_	3	conj	_	_
9	proteins	protein	NNS	NNS	_	3	dep	_	_
10	in	in	IN	IN	_	12	case	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	1	nmod	_	_
13	to	to	TO	TO	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	IL-2	il-2	NN	NN	_	20	compound	_	_
16	promoter	promoter	NN	NN	_	20	compound	_	_
17	CD28	cd28	NN	NN	_	20	compound	_	_
18	response	response	NN	NN	_	20	compound	_	_
19	element/AP-1	element/ap-1	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	12	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	12	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	CD28	cd28	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	costimulatory	costimulatory	JJ	JJ	_	6	amod	_	_
6	molecule	molecule	NN	NN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Costimulation	costimulation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	through	through	IN	IN	_	9	case	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Ag	ag	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	1	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CD28	cd28	NN	NN	_	9	conj	_	_
12	leads	lead	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	17	case	_	_
14	high	high	JJ	JJ	_	17	amod	_	_
15	level	level	NN	NN	_	17	compound	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	vital	vital	JJ	JJ	_	17	acl:relcl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	development	development	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	response	response	NN	NN	_	24	nmod	_	_
29	in	in	FW	FW	_	24	amod	_	_
30	vivo	vivo	FW	FW	_	29	dep	_	_
31	.	.	.	.	_	12	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CD28	cd28	NN	NN	_	7	compound	_	_
7	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
8	contributes	contribute	VBZ	VBZ	_	4	ccomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	up-regulating	up-regulate	VBG	VBG	_	8	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activity	activity	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	several	several	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	including	include	VBG	VBG	_	26	case	_	_
26	AP-1	ap-1	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	nuclear	nuclear	JJ	JJ	_	35	amod	_	_
29	factor-kappaB	factor-kappab	NN	NN	_	35	compound	_	_
30	(	(	-LRB-	-LRB-	_	35	punct	_	_
31	NF-kappaB	nf-kappab	NN	NN	_	35	compound	_	_
32	)	)	-RRB-	-RRB-	_	35	punct	_	_
33	/Rel	/rel	NN	NN	_	35	compound	_	_
34	family	family	NN	NN	_	35	compound	_	_
35	members	member	NNS	NNS	_	26	conj	_	_
36	as	as	RB	RB	_	26	cc	_	_
37	well	well	RB	RB	_	36	mwe	_	_
38	as	as	IN	IN	_	36	mwe	_	_
39	an	a	DT	DT	_	42	det	_	_
40	uncharacterized	uncharacterized	JJ	JJ	_	42	amod	_	_
41	transcription	transcription	NN	NN	_	42	compound	_	_
42	factor	factor	NN	NN	_	26	conj	_	_
43	called	call	VBN	VBN	_	42	acl	_	_
44	CD28	cd28	NN	NN	_	46	compound	_	_
45	response	response	NN	NN	_	46	compound	_	_
46	complex	complex	NN	NN	_	43	xcomp	_	_
47	.	.	.	.	_	4	punct	_	_

1	While	while	IN	IN	_	7	mark	_	_
2	several	several	JJ	JJ	_	3	amod	_	_
3	lines	line	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	investigation	investigation	NN	NN	_	3	nmod	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	suggested	suggest	VBN	VBN	_	25	advcl	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	11	compound	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	12	nsubj	_	_
12	make	make	VBP	VBP	_	7	ccomp	_	_
13	up	up	RB	RB	_	12	compound:prt	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CD28	cd28	NN	NN	_	17	compound	_	_
16	response	response	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	12	dobj	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	17	dep	_	_
20	,	,	,	,	_	25	punct	_	_
21	other	other	JJ	JJ	_	22	amod	_	_
22	work	work	NN	NN	_	25	nsubj	_	_
23	has	have	VBZ	VBZ	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	supported	support	VBN	VBN	_	0	root	_	_
26	this	this	DT	DT	_	27	det	_	_
27	conclusion	conclusion	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	25	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	CD28	cd28	NN	NN	_	8	compound	_	_
7	response	response	NN	NN	_	8	compound	_	_
8	element	element	NN	NN	_	14	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CD28RE	cd28re	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	function	function	VB	VB	_	3	ccomp	_	_
15	independently	independently	RB	RB	_	14	advmod	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	works	work	VBZ	VBZ	_	14	conj	_	_
18	instead	instead	RB	RB	_	17	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	conjunction	conjunction	NN	NN	_	17	nmod	_	_
21	with	with	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	adjacent	adjacent	JJ	JJ	_	27	amod	_	_
24	promoter	promoter	NN	NN	_	27	compound	_	_
25	proximal	proximal	JJ	JJ	_	27	amod	_	_
26	AP-1-binding	ap-1-binding	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	20	nmod	_	_
28	and	and	CC	CC	_	3	cc	_	_
29	this	this	DT	DT	_	30	det	_	_
30	hypothesis	hypothesis	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	confirmed	confirm	VBN	VBN	_	3	conj	_	_
33	here	here	RB	RB	_	32	advmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Also	also	RB	RB	_	18	advmod	_	_
2	in	in	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	current	current	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	18	nmod	_	_
6	,	,	,	,	_	18	punct	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	18	nsubjpass	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CD28RE/AP-1	cd28re/ap-1	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-2	il-2	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	evaluated	evaluate	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	four	four	CD	CD	_	4	nummod	_	_
3	specific	specific	JJ	JJ	_	4	amod	_	_
4	complexes	complex	NNS	NNS	_	7	nsubjpass	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	19	advcl	_	_
8	binding	bind	VBG	VBG	_	7	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	sequence	sequence	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	19	punct	_	_
13	only	only	RB	RB	_	14	advmod	_	_
14	one	one	CD	CD	_	19	nsubj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	complexes	complex	NNS	NNS	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	specific	specific	JJ	JJ	_	0	root	_	_
20	for	for	IN	IN	_	23	case	_	_
21	both	both	CC	CC	_	23	cc:preconj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	CD28RE	cd28re	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	28	det	_	_
26	adjacent	adjacent	JJ	JJ	_	28	amod	_	_
27	AP-1	ap-1	NN	NN	_	28	compound	_	_
28	site	site	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	19	punct	_	_

1	Of	of	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	5	compound	_	_
4	family	family	NN	NN	_	5	compound	_	_
5	members	member	NNS	NNS	_	11	nmod	_	_
6	tested	test	VBN	VBN	_	5	acl	_	_
7	,	,	,	,	_	11	punct	_	_
8	this	this	DT	DT	_	10	det	_	_
9	CD28RE/AP-1-specific	cd28re/ap-1-specific	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	0	root	_	_
12	predominantly	predominantly	RB	RB	_	11	advmod	_	_
13	c-Rel	c-rel	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	11	punct	_	_
15	despite	despite	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	fact	fact	NN	NN	_	11	nmod	_	_
18	that	that	IN	IN	_	25	mark	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	p50	p50	NN	NN	_	25	nsubj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	RelA	rela	NN	NN	_	20	conj	_	_
23	can	can	MD	MD	_	25	aux	_	_
24	efficiently	efficiently	RB	RB	_	25	advmod	_	_
25	bind	bind	VB	VB	_	17	ccomp	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	CD28RE	cd28re	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	c-Fos	c-fos	NN	NN	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	c-Jun	c-jun	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	this	this	DT	DT	_	10	det	_	_
9	CD28RE/AP-1-specific	cd28re/ap-1-specific	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	15	nsubj	_	_
7	encompassing	encompass	VBG	VBG	_	6	acl	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	the	the	DT	DT	_	10	det	_	_
10	CD28RE	cd28re	NN	NN	_	7	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	AP-1-binding	ap-1-binding	JJ	JJ	_	14	amod	_	_
14	sites	site	NNS	NNS	_	10	conj	_	_
15	influence	influence	VBP	VBP	_	3	ccomp	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	CD28-costimulated	cd28-costimulated	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	c-Myb	c-myb	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Ets	ets	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	1	conj	_	_
5	synergize	synergize	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	overcome	overcome	VB	VB	_	5	xcomp	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	repression	repression	NN	NN	_	7	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ZEB	zeb	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Zfh	zfh	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	zinc	zinc	NN	NN	_	7	compound	_	_
6	finger/homeodomain	finger/homeodomain	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	first	first	RB	RB	_	10	advmod	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	Drosophila	drosophila	FW	FW	_	10	nmod	_	_
13	where	where	WRB	WRB	_	16	advmod	_	_
14	it	it	PRP	PRP	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	required	require	VBN	VBN	_	12	acl:relcl	_	_
17	for	for	IN	IN	_	18	case	_	_
18	differentiation	differentiation	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	tissues	tissue	NNS	NNS	_	18	nmod	_	_
21	such	such	JJ	JJ	_	26	case	_	_
22	as	as	IN	IN	_	21	mwe	_	_
23	the	the	DT	DT	_	26	det	_	_
24	central	central	JJ	JJ	_	26	amod	_	_
25	nervous	nervous	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	20	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	muscle	muscle	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	ZEB	zeb	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	vertebrate	vertebrate	JJ	JJ	_	5	amod	_	_
5	homolog	homolog	NN	NN	_	1	appos	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Zfh-1	zfh-1	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	binds	bind	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	11	det	_	_
11	subset	subset	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	E	e	NN	NN	_	14	compound	_	_
14	boxes	box	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	blocks	block	VBZ	VBZ	_	9	conj	_	_
17	myogenesis	myogenesis	NN	NN	_	16	dobj	_	_
18	through	through	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	repression	repression	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	muscle	muscle	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	here	here	RB	RB	_	2	advmod	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	ZEB	zeb	NN	NN	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	has	have	VBZ	VBZ	_	2	dep	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	controlling	control	VBG	VBG	_	8	advcl	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	15	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	families	family	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	2	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	2	acl:relcl	_	_
9	for	for	IN	IN	_	11	case	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	hematopoiesis	hematopoiesis	NN	NN	_	8	nmod	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	c-Myb	c-myb	NN	NN	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Ets	ets	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	factors	factor	NNS	NNS	_	3	nsubj	_	_
3	act	act	VBP	VBP	_	0	root	_	_
4	synergistically	synergistically	RB	RB	_	3	advmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	activate	activate	VB	VB	_	3	xcomp	_	_
7	transcription	transcription	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	this	this	DT	DT	_	11	det	_	_
11	synergy	synergy	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	required	require	VBN	VBN	_	3	conj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	at	at	IN	IN	_	18	case	_	_
18	least	least	JJS	JJS	_	19	nmod:npmod	_	_
19	several	several	JJ	JJ	_	22	nummod	_	_
20	important	important	JJ	JJ	_	22	amod	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	ZEB	zeb	NN	NN	_	2	nsubj	_	_
2	blocks	block	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activity	activity	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	c-Myb	c-myb	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Ets	ets	NN	NN	_	6	conj	_	_
9	individually	individually	RB	RB	_	2	advmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	but	but	CC	CC	_	2	cc	_	_
12	together	together	RB	RB	_	15	advmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	factors	factor	NNS	NNS	_	15	nsubj	_	_
15	synergize	synergize	VBP	VBP	_	2	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	resist	resist	VB	VB	_	15	xcomp	_	_
18	this	this	DT	DT	_	19	det	_	_
19	repression	repression	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	2	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	repression	repression	NN	NN	_	3	nsubj	_	_
3	imposes	impose	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	requirement	requirement	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	c-Myb	c-myb	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Ets	ets	NN	NN	_	8	conj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	providing	provide	VBG	VBG	_	3	advcl	_	_
16	one	one	CD	CD	_	17	nummod	_	_
17	explanation	explanation	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	25	mark	_	_
19	why	why	WRB	WRB	_	25	advmod	_	_
20	synergy	synergy	NN	NN	_	25	nsubj	_	_
21	between	between	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	factors	factor	NNS	NNS	_	20	nmod	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	important	important	JJ	JJ	_	17	acl	_	_
26	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	balance	balance	NN	NN	_	12	nsubj	_	_
3	between	between	IN	IN	_	4	case	_	_
4	repression	repression	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	ZEB	zeb	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	4	conj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	c-Myb/Ets	c-myb/ets	NN	NN	_	9	nmod	_	_
12	provides	provide	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	16	det	_	_
14	flexible	flexible	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	mechanism	mechanism	NN	NN	_	12	dobj	_	_
17	for	for	IN	IN	_	18	mark	_	_
18	controlling	control	VBG	VBG	_	16	acl	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	one	one	CD	CD	_	5	nummod	_	_
5	target	target	NN	NN	_	15	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	positive/negative	positive/negative	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	5	nmod	_	_
10	in	in	FW	FW	_	9	amod	_	_
11	vivo	vivo	FW	FW	_	10	dep	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	the	the	DT	DT	_	15	det	_	_
14	alpha4	alpha4	NN	NN	_	15	compound	_	_
15	integrin	integrin	NN	NN	_	2	ccomp	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	play	play	VBP	VBP	_	15	acl:relcl	_	_
19	a	a	DT	DT	_	21	det	_	_
20	key	key	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	hematopoiesis	hematopoiesis	NN	NN	_	18	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	function	function	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	mature	mature	JJ	JJ	_	29	amod	_	_
29	leukocytes	leukocyte	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	GABP	gabp	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	3	nsubj	_	_
3	bind	bind	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	12	case	_	_
5	a	a	DT	DT	_	12	det	_	_
6	distal	distal	JJ	JJ	_	12	amod	_	_
7	interleukin	interleukin	NN	NN	_	12	compound	_	_
8	2	2	CD	CD	_	12	nummod	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	IL-2	il-2	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	enhancer	enhancer	NN	NN	_	3	nmod	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	contribute	contribute	VBP	VBP	_	3	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	c-Raf-mediated	c-raf-mediated	JJ	JJ	_	17	amod	_	_
17	increase	increase	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Triggering	triggering	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	T-cell	t-cell	NN	NN	_	6	compound	_	_
5	receptor-CD3	receptor-cd3	JJ	JJ	_	6	amod	_	_
6	complex	complex	NN	NN	_	1	nmod	_	_
7	activates	activate	VBZ	VBZ	_	0	root	_	_
8	two	two	CD	CD	_	11	nummod	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	cascades	cascade	NNS	NNS	_	7	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	i	i	LS	LS	_	21	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	Ca2+-dependent	ca2+-dependent	JJ	JJ	_	21	amod	_	_
20	signal	signal	NN	NN	_	21	compound	_	_
21	cascades	cascade	NNS	NNS	_	11	appos	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	ii	ii	LS	LS	_	28	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	kinase	kinase	NN	NN	_	28	compound	_	_
28	cascades	cascade	NNS	NNS	_	21	conj	_	_
29	.	.	.	.	_	7	punct	_	_

1	Both	both	DT	DT	_	3	det	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	cascades	cascade	NNS	NNS	_	4	nsubj	_	_
4	contribute	contribute	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	det	_	_
10	interleukin	interleukin	NN	NN	_	15	compound	_	_
11	2	2	CD	CD	_	15	nummod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	IL-2	il-2	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	gene	gene	NN	NN	_	7	nmod	_	_
16	during	during	IN	IN	_	18	case	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	4	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Prominent	prominent	JJ	JJ	_	4	amod	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	cascades	cascade	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	those	those	DT	DT	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	activate	activate	VBP	VBP	_	6	acl:relcl	_	_
9	mitogen-activated	mitogen-activated	JJ	JJ	_	14	amod	_	_
10	protein	protein	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	MAP	map	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	kinases	kinase	NNS	NNS	_	8	dobj	_	_
15	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	c-Raf	c-raf	NN	NN	_	18	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	at	at	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	helm	helm	NN	NN	_	5	acl:relcl	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	classic	classic	JJ	JJ	_	16	amod	_	_
15	MAP-Erk	map-erk	JJ	JJ	_	16	amod	_	_
16	cascade	cascade	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	contributes	contribute	VBZ	VBZ	_	2	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	induction	induction	NN	NN	_	18	nmod	_	_
22	through	through	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	distal	distal	JJ	JJ	_	26	amod	_	_
25	enhancer	enhancer	NN	NN	_	26	compound	_	_
26	element	element	NN	NN	_	21	nmod	_	_
27	spanning	span	VBG	VBG	_	26	acl	_	_
28	the	the	DT	DT	_	29	det	_	_
29	nucleotides	nucleotide	NNS	NNS	_	27	dobj	_	_
30	from	from	IN	IN	_	31	case	_	_
31	positions	position	NNS	NNS	_	27	nmod	_	_
32	-502	-502	CD	CD	_	34	compound	_	_
33	to	to	TO	TO	_	34	dep	_	_
34	-413	-413	CD	CD	_	31	nummod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	front	front	NN	NN	_	27	nmod	_	_
37	of	of	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	transcriptional	transcriptional	JJ	JJ	_	41	amod	_	_
40	start	start	NN	NN	_	41	compound	_	_
41	site	site	NN	NN	_	36	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	IL-2	il-2	NN	NN	_	45	compound	_	_
45	gene	gene	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	2	punct	_	_

1	Induction	induction	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	this	this	DT	DT	_	6	det	_	_
4	distal	distal	JJ	JJ	_	6	amod	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	enhancer	enhancer	NN	NN	_	1	nmod	_	_
7	differs	differ	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	induction	induction	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	proximal	proximal	JJ	JJ	_	14	amod	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	promoter-enhancer	promoter-enhancer	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	since	since	IN	IN	_	19	mark	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	induced	induce	VBN	VBN	_	7	advcl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	phorbol	phorbol	NN	NN	_	22	compound	_	_
22	esters	ester	NNS	NNS	_	19	nmod	_	_
23	alone	alone	RB	RB	_	22	advmod	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	independent	independent	JJ	JJ	_	19	conj	_	_
26	from	from	IN	IN	_	28	case	_	_
27	Ca2+	ca2+	NN	NN	_	28	compound	_	_
28	signals	signal	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	DNA-protein	dna-protein	JJ	JJ	_	4	amod	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	detected	detect	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	GABP	gabp	NN	NN	_	12	dep	_	_
14	alpha	alpha	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	-beta	-beta	NN	NN	_	13	conj	_	_
17	to	to	TO	TO	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	dyad	dyad	JJ	JJ	_	21	amod	_	_
20	symmetry	symmetry	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	9	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	DSE	dse	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	distal	distal	JJ	JJ	_	28	amod	_	_
28	enhancer	enhancer	NN	NN	_	21	nmod	_	_
29	,	,	,	,	_	21	punct	_	_
30	which	which	WDT	WDT	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	formed	form	VBN	VBN	_	21	acl:relcl	_	_
33	by	by	IN	IN	_	36	case	_	_
34	palindromic	palindromic	JJ	JJ	_	36	amod	_	_
35	binding	bind	VBG	VBG	_	36	amod	_	_
36	sites	site	NNS	NNS	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	Ets-like	ets-like	JJ	JJ	_	39	amod	_	_
39	factors	factor	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	7	punct	_	_

1	Introduction	introduction	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	point	point	NN	NN	_	4	compound	_	_
4	mutations	mutation	NNS	NNS	_	1	nmod	_	_
5	suppressing	suppress	VBG	VBG	_	4	acl	_	_
6	GABP	gabp	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	DSE	dse	NN	NN	_	7	nmod	_	_
11	interfered	interfere	VBD	VBD	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	distal	distal	JJ	JJ	_	18	amod	_	_
18	enhancer	enhancer	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	entire	entire	JJ	JJ	_	23	amod	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	promoter-enhancer	promoter-enhancer	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	11	punct	_	_
25	while	while	IN	IN	_	31	mark	_	_
26	overexpression	overexpression	NN	NN	_	31	nsubj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	both	both	DT	DT	_	30	dep	_	_
29	GABP	gabp	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	26	nmod	_	_
31	enhanced	enhance	VBD	VBD	_	11	advcl	_	_
32	the	the	DT	DT	_	35	det	_	_
33	IL-2	il-2	NN	NN	_	35	compound	_	_
34	promoter-enhancer	promoter-enhancer	JJ	JJ	_	33	amod	_	_
35	induction	induction	NN	NN	_	31	dobj	_	_
36	.	.	.	.	_	11	punct	_	_

1	Overexpression	overexpression	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	BXB	bxb	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	8	det	_	_
6	constitutive	constitutive	JJ	JJ	_	7	amod	_	_
7	active	active	JJ	JJ	_	8	amod	_	_
8	version	version	NN	NN	_	3	appos	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-Raf	c-raf	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	of	of	IN	IN	_	15	case	_	_
14	further	further	JJ	JJ	_	15	amod	_	_
15	members	member	NNS	NNS	_	3	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	Ras-Raf-Erk	ras-raf-erk	JJ	JJ	_	20	amod	_	_
19	signal	signal	NN	NN	_	20	compound	_	_
20	cascade	cascade	NN	NN	_	15	nmod	_	_
21	exerted	exert	VBD	VBD	_	0	root	_	_
22	an	a	DT	DT	_	23	det	_	_
23	increase	increase	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	GABP-mediated	gabp-mediated	JJ	JJ	_	27	amod	_	_
26	promoter-enhancer	promoter-enhancer	JJ	JJ	_	27	amod	_	_
27	induction	induction	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conjunction	conjunction	NN	NN	_	35	nmod	_	_
3	with	with	IN	IN	_	6	case	_	_
4	previously	previously	RB	RB	_	5	advmod	_	_
5	published	publish	VBN	VBN	_	6	amod	_	_
6	data	datum	NNS	NNS	_	2	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	c-Raf-induced	c-raf-induced	JJ	JJ	_	9	amod	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	GABP	gabp	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	E.Flory	E.Flory	NNP	NNP	_	6	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	A.	A.	NNP	NNP	_	17	compound	_	_
17	Hoffmeyer	Hoffmeyer	NNP	NNP	_	14	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	U.Smola	U.Smola	NNP	NNP	_	14	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	U.R.Rapp	U.R.Rapp	NNP	NNP	_	14	conj	_	_
22	,	,	,	,	_	14	punct	_	_
23	and	and	CC	CC	_	14	cc	_	_
24	J.T.Bruder	J.T.Bruder	NNP	NNP	_	14	conj	_	_
25	,	,	,	,	_	14	punct	_	_
26	J.Virol.70	J.Virol.70	NNP	NNP	_	14	appos	_	_
27	:	:	:	:	_	14	punct	_	_
28	2260-2268	2260-2268	CD	CD	_	14	dep	_	_
29	,	,	,	,	_	14	punct	_	_
30	1996	1996	CD	CD	_	14	amod	_	_
31	)	)	-RRB-	-RRB-	_	14	punct	_	_
32	,	,	,	,	_	35	punct	_	_
33	these	these	DT	DT	_	34	det	_	_
34	results	result	NNS	NNS	_	35	nsubj	_	_
35	indicate	indicate	VBP	VBP	_	0	root	_	_
36	a	a	DT	DT	_	37	det	_	_
37	contribution	contribution	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	GABP	gabp	NN	NN	_	40	compound	_	_
40	factors	factor	NNS	NNS	_	37	nmod	_	_
41	to	to	TO	TO	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	Raf-mediated	raf-mediated	JJ	JJ	_	44	amod	_	_
44	enhancement	enhancement	NN	NN	_	37	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	IL-2	il-2	NN	NN	_	47	compound	_	_
47	induction	induction	NN	NN	_	44	nmod	_	_
48	during	during	IN	IN	_	50	case	_	_
49	T-cell	t-cell	NN	NN	_	50	compound	_	_
50	activation	activation	NN	NN	_	37	nmod	_	_
51	.	.	.	.	_	35	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	product	product	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	murine	murine	JJ	JJ	_	6	amod	_	_
6	homolog	homolog	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	Drosophila	drosophila	FW	FW	_	13	compound	_	_
10	extra	extra	JJ	JJ	_	13	amod	_	_
11	sex	sex	NN	NN	_	13	compound	_	_
12	combs	comb	NNS	NNS	_	13	compound	_	_
13	gene	gene	NN	NN	_	6	nmod	_	_
14	displays	display	VBZ	VBZ	_	0	root	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	repressor	repressor	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	heterogeneous	heterogeneous	JJ	JJ	_	6	amod	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	ribonucleoprotein	ribonucleoprotein	NN	NN	_	6	compound	_	_
5	K	k	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	7	nsubj	_	_
7	represents	represent	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	class	class	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	proteins	protein	NNS	NNS	_	10	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	act	act	VB	VB	_	10	acl:relcl	_	_
16	as	as	IN	IN	_	18	case	_	_
17	docking	docking	NN	NN	_	18	compound	_	_
18	platforms	platform	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	orchestrate	orchestrate	VBP	VBP	_	18	acl:relcl	_	_
21	cross-talk	cross-talk	NN	NN	_	20	dobj	_	_
22	among	among	IN	IN	_	23	case	_	_
23	molecules	molecule	NNS	NNS	_	21	nmod	_	_
24	involved	involve	VBN	VBN	_	23	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	signal	signal	NN	NN	_	27	compound	_	_
27	transduction	transduction	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	3	det	_	_
3	fragment	fragment	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	K	k	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	3	nmod	_	_
7	as	as	IN	IN	_	8	case	_	_
8	bait	bait	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	yeast	yeast	NN	NN	_	13	compound	_	_
12	two-hybrid	two-hybrid	JJ	JJ	_	13	amod	_	_
13	screen	screen	NN	NN	_	1	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	isolated	isolate	VBD	VBD	_	1	parataxis	_	_
17	a	a	DT	DT	_	18	det	_	_
18	cDNA	cdna	NN	NN	_	16	dobj	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	encodes	encode	VBZ	VBZ	_	18	acl:relcl	_	_
21	a	a	DT	DT	_	22	det	_	_
22	protein	protein	NN	NN	_	20	dobj	_	_
23	whose	whose	WP$	WP$	_	25	nmod:poss	_	_
24	primary	primary	JJ	JJ	_	25	amod	_	_
25	structure	structure	NN	NN	_	26	nsubj	_	_
26	has	have	VBZ	VBZ	_	22	acl:relcl	_	_
27	extensive	extensive	JJ	JJ	_	28	amod	_	_
28	similarity	similarity	NN	NN	_	26	dobj	_	_
29	to	to	TO	TO	_	40	case	_	_
30	the	the	DT	DT	_	40	det	_	_
31	Drosophila	drosophila	FW	FW	_	40	compound	_	_
32	melanogaster	melanogaster	FW	FW	_	40	compound	_	_
33	extra	extra	FW	FW	_	40	compound	_	_
34	sex	sex	NN	NN	_	40	compound	_	_
35	combs	comb	NNS	NNS	_	40	compound	_	_
36	(	(	-LRB-	-LRB-	_	40	punct	_	_
37	esc	esc	NNS	NNS	_	40	compound	_	_
38	)	)	-RRB-	-RRB-	_	40	punct	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	product	product	NN	NN	_	28	nmod	_	_
41	,	,	,	,	_	40	punct	_	_
42	Esc	esc	NN	NN	_	40	appos	_	_
43	,	,	,	,	_	42	punct	_	_
44	a	a	DT	DT	_	46	det	_	_
45	putative	putative	JJ	JJ	_	46	amod	_	_
46	silencer	silencer	NN	NN	_	42	appos	_	_
47	of	of	IN	IN	_	49	case	_	_
48	homeotic	homeotic	JJ	JJ	_	49	amod	_	_
49	genes	gene	NNS	NNS	_	46	nmod	_	_
50	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cDNA	cdna	NN	NN	_	7	nsubj	_	_
3	that	that	WDT	WDT	_	5	dobj	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	isolated	isolate	VBD	VBD	_	2	acl:relcl	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	identical	identical	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cDNA	cdna	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	20	case	_	_
12	the	the	DT	DT	_	20	det	_	_
13	recently	recently	RB	RB	_	15	advmod	_	_
14	positionally	positionally	RB	RB	_	13	advmod	_	_
15	cloned	clone	VBN	VBN	_	20	amod	_	_
16	mouse	mouse	NN	NN	_	20	compound	_	_
17	embryonic	embryonic	JJ	JJ	_	20	amod	_	_
18	ectoderm	ectoderm	NN	NN	_	20	compound	_	_
19	development	development	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	10	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	eed	eed	NN	NN	_	20	appos	_	_
23	.	.	.	.	_	7	punct	_	_

1	Like	like	IN	IN	_	2	case	_	_
2	Esc	esc	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	Eed	eed	NN	NN	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	0	root	_	_
6	six	six	CD	CD	_	8	nummod	_	_
7	WD-40	wd-40	NN	NN	_	8	compound	_	_
8	repeats	repeat	NNS	NNS	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	C-terminal	c-terminal	JJ	JJ	_	12	amod	_	_
12	half	half	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	protein	protein	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	thought	think	VBN	VBN	_	5	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	repress	repress	VB	VB	_	18	xcomp	_	_
21	homeotic	homeotic	JJ	JJ	_	23	amod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	20	dobj	_	_
24	during	during	IN	IN	_	26	case	_	_
25	mouse	mouse	NN	NN	_	26	compound	_	_
26	embryogenesis	embryogenesis	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Eed	eed	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	5	case	_	_
4	K	k	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	through	through	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	domain	domain	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	N	n	NN	NN	_	12	compound	_	_
12	terminus	terminus	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	but	but	CC	CC	_	2	cc	_	_
15	interestingly	interestingly	RB	RB	_	21	advmod	_	_
16	,	,	,	,	_	21	punct	_	_
17	this	this	DT	DT	_	18	det	_	_
18	domain	domain	NN	NN	_	21	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	found	find	VBN	VBN	_	2	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	Drosophila	drosophila	FW	FW	_	25	dep	_	_
25	Esc	esc	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Gal4-Eed	gal4-eed	JJ	JJ	_	3	amod	_	_
2	fusion	fusion	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	represses	repress	VBZ	VBZ	_	0	root	_	_
5	transcription	transcription	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	driven	drive	VBN	VBN	_	5	acl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	promoter	promoter	NN	NN	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	contains	contain	VBZ	VBZ	_	13	acl:relcl	_	_
16	Gal4-binding	gal4-binding	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Eed	eed	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	represses	repress	VBZ	VBZ	_	0	root	_	_
4	transcription	transcription	NN	NN	_	3	dobj	_	_
5	when	when	WRB	WRB	_	6	advmod	_	_
6	recruited	recruit	VBN	VBN	_	3	advcl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	Gal4-K	gal4-k	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Point	point	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	15	nsubj	_	_
3	within	within	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	eed	eed	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	that	that	WDT	WDT	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	responsible	responsible	JJ	JJ	_	2	acl:relcl	_	_
10	for	for	IN	IN	_	14	case	_	_
11	severe	severe	JJ	JJ	_	14	amod	_	_
12	embryonic	embryonic	JJ	JJ	_	14	amod	_	_
13	development	development	NN	NN	_	14	compound	_	_
14	abnormalities	abnormality	NNS	NNS	_	9	nmod	_	_
15	abolished	abolish	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	19	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	repressor	repressor	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Eed	eed	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Results	result	NNS	NNS	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	1	nmod	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	Eed-restricted	eed-restricted	JJ	JJ	_	10	amod	_	_
8	homeotic	homeotic	JJ	JJ	_	7	dep	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	13	nsubj	_	_
11	during	during	IN	IN	_	12	case	_	_
12	embryogenesis	embryogenesis	NN	NN	_	10	nmod	_	_
13	reflects	reflect	VBZ	VBZ	_	5	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	action	action	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Eed	eed	NN	NN	_	15	nmod	_	_
18	as	as	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	repressor	repressor	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Eed-mediated	eed-mediated	JJ	JJ	_	4	amod	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	likely	likely	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	reflect	reflect	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	interaction	interaction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Eed	eed	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	multiple	multiple	JJ	JJ	_	16	amod	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	partners	partner	NNS	NNS	_	10	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	20	case	_	_
19	K	k	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	3	nsubj	_	_
3	regulates	regulate	VBZ	VBZ	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	L-selectin	l-selectin	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD11/CD18	cd11/cd18	NN	NN	_	6	conj	_	_
9	on	on	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	neutrophils	neutrophil	NNS	NNS	_	4	nmod	_	_
12	-LSB-	-lsb-	-LRB-	-LRB-	_	13	punct	_	_
13	see	see	VB	VB	_	3	parataxis	_	_
14	comments	comment	NNS	NNS	_	13	dobj	_	_
15	-RSB-	-rsb-	-RRB-	-RRB-	_	13	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Recent	recent	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	raised	raise	VBN	VBN	_	1	dep	_	_
7	the	the	DT	DT	_	8	det	_	_
8	hypothesis	hypothesis	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	glucocorticoids	glucocorticoid	NNS	NNS	_	12	nsubj	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	diminish	diminish	VB	VB	_	8	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	endothelial	endothelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	direct	direct	VB	VB	_	14	acl	_	_
20	leukocyte	leukocyte	NN	NN	_	19	dobj	_	_
21	traffic	traffic	JJ	JJ	_	20	amod	_	_
22	into	into	IN	IN	_	24	case	_	_
23	inflamed	inflamed	JJ	JJ	_	24	amod	_	_
24	tissues	tissue	NNS	NNS	_	19	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	inhibiting	inhibit	VBG	VBG	_	12	advcl	_	_
27	expression	expression	NN	NN	_	26	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	adhesion	adhesion	NN	NN	_	31	compound	_	_
31	molecules	molecule	NNS	NNS	_	27	nmod	_	_
32	endothelial-leukocyte	endothelial-leukocyte	JJ	JJ	_	34	amod	_	_
33	adhesion	adhesion	NN	NN	_	34	compound	_	_
34	molecule-1	molecule-1	NN	NN	_	31	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	intercellular	intercellular	JJ	JJ	_	38	amod	_	_
37	adhesion	adhesion	NN	NN	_	38	compound	_	_
38	molecule-1	molecule-1	NN	NN	_	34	conj	_	_
39	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	investigate	investigate	VB	VB	_	7	xcomp	_	_
10	whether	whether	IN	IN	_	13	mark	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	13	nsubj	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	regulate	regulate	VBP	VBP	_	9	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	L-selectin	l-selectin	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	CD11/CD18	cd11/cd18	NN	NN	_	17	conj	_	_
20	integrins	integrin	NNS	NNS	_	19	dep	_	_
21	on	on	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	neutrophil	neutrophil	NN	NN	_	24	compound	_	_
24	granulocytes	granulocyte	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	RESULTS	result	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Incubation	incubation	NN	NN	_	19	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	whole	whole	JJ	JJ	_	9	amod	_	_
9	blood	blood	NN	NN	_	5	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	platelet-activating	platelet-activating	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PAF	paf	NN	NN	_	12	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	mumol/L	mumol/l	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	14	punct	_	_
19	evoked	evoke	VBD	VBD	_	1	dep	_	_
20	downregulation	downregulation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	L-selectin	l-selectin	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	20	cc	_	_
24	upregulation	upregulation	NN	NN	_	20	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	CD11/CD18	cd11/cd18	NN	NN	_	24	nmod	_	_
27	adhesion	adhesion	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	26	dep	_	_
29	on	on	IN	IN	_	30	case	_	_
30	neutrophils	neutrophil	NNS	NNS	_	24	nmod	_	_
31	as	as	IN	IN	_	32	mark	_	_
32	measured	measure	VBN	VBN	_	19	advcl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	flow	flow	NN	NN	_	35	compound	_	_
35	cytometry	cytometry	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	1	punct	_	_

1	While	while	IN	IN	_	12	mark	_	_
2	dexamethasone	dexamethasone	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	0.1	0.1	CD	CD	_	5	nummod	_	_
5	nmol/L	nmol/l	NN	NN	_	2	dep	_	_
6	to	to	TO	TO	_	8	case	_	_
7	100	100	CD	CD	_	8	nummod	_	_
8	mumol/L	mumol/l	NN	NN	_	5	nmod	_	_
9	)	)	-RRB-	-RRB-	_	5	punct	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	affect	affect	VB	VB	_	22	advcl	_	_
13	expression	expression	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	adhesion	adhesion	NN	NN	_	16	compound	_	_
16	molecules	molecule	NNS	NNS	_	13	nmod	_	_
17	on	on	IN	IN	_	19	case	_	_
18	resting	rest	VBG	VBG	_	19	amod	_	_
19	neutrophils	neutrophil	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	it	it	PRP	PRP	_	22	nsubj	_	_
22	attenuated	attenuate	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	25	det	_	_
24	PAF-induced	paf-induced	JJ	JJ	_	25	amod	_	_
25	changes	change	NNS	NNS	_	22	dobj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	L-selectin	l-selectin	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD18	cd18	NN	NN	_	27	conj	_	_
30	expression	expression	NN	NN	_	27	dep	_	_
31	in	in	IN	IN	_	36	case	_	_
32	a	a	DT	DT	_	36	det	_	_
33	time-	time-	NN	NN	_	36	amod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	concentration-dependent	concentration-dependent	JJ	JJ	_	33	conj	_	_
36	fashion	fashion	NN	NN	_	22	nmod	_	_
37	with	with	IN	IN	_	39	case	_	_
38	IC50	ic50	NN	NN	_	39	compound	_	_
39	values	value	NNS	NNS	_	22	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	31	31	CD	CD	_	39	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	13	13	CD	CD	_	41	conj	_	_
44	nmol/L	nmol/l	NN	NN	_	41	dep	_	_
45	,	,	,	,	_	39	punct	_	_
46	respectively	respectively	RB	RB	_	39	advmod	_	_
47	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	dexamethasone	dexamethasone	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	completely	completely	RB	RB	_	7	advmod	_	_
7	aborted	abort	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	RU-486	ru-486	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	10	10	CD	CD	_	12	nummod	_	_
12	mumol/L	mumol/l	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	9	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	blocks	block	VBZ	VBZ	_	9	acl:relcl	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	9	punct	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	protein	protein	NN	NN	_	29	compound	_	_
28	synthesis	synthesis	NN	NN	_	29	compound	_	_
29	inhibitor	inhibitor	NN	NN	_	9	conj	_	_
30	cycloheximide	cycloheximide	NN	NN	_	29	dep	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	35.5	35.5	CD	CD	_	33	nummod	_	_
33	mumol/L	mumol/l	NN	NN	_	29	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	7	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	12	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	up	up	RB	RB	_	6	advmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	concentration	concentration	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	mumol/L	mumol/l	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	neither	neither	CC	CC	_	12	cc:preconj	_	_
12	affected	affect	VBD	VBD	_	0	root	_	_
13	significantly	significantly	RB	RB	_	12	advmod	_	_
14	the	the	DT	DT	_	15	det	_	_
15	release	release	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	granule	granule	NN	NN	_	18	compound	_	_
18	enzymes	enzyme	NNS	NNS	_	15	nmod	_	_
19	nor	nor	CC	CC	_	12	cc	_	_
20	interfered	interfere	VBD	VBD	_	12	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	PAF	paf	NN	NN	_	20	nmod	_	_
23	binding	bind	VBG	VBG	_	22	acl	_	_
24	to	to	TO	TO	_	27	case	_	_
25	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
26	membrane	membrane	NN	NN	_	27	compound	_	_
27	receptors	receptor	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	glucocorticoids	glucocorticoid	NNS	NNS	_	12	nsubj	_	_
8	at	at	IN	IN	_	11	case	_	_
9	clinically	clinically	RB	RB	_	10	advmod	_	_
10	relevant	relevant	JJ	JJ	_	11	amod	_	_
11	concentrations	concentration	NNS	NNS	_	7	nmod	_	_
12	exert	exert	VBP	VBP	_	5	ccomp	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	actions	action	NNS	NNS	_	12	dobj	_	_
15	on	on	IN	IN	_	16	case	_	_
16	expression	expression	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	adhesion	adhesion	NN	NN	_	19	compound	_	_
19	molecules	molecule	NNS	NNS	_	16	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	activated	activate	VBN	VBN	_	22	amod	_	_
22	neutrophils	neutrophil	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	which	which	WDT	WDT	_	26	nsubjpass	_	_
25	are	be	VBP	VBP	_	26	auxpass	_	_
26	mediated	mediate	VBN	VBN	_	14	acl:relcl	_	_
27	through	through	IN	IN	_	28	case	_	_
28	ligation	ligation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	glucocorticoid	glucocorticoid	NN	NN	_	31	compound	_	_
31	receptors	receptor	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	induction	induction	NN	NN	_	28	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	protein	protein	NN	NN	_	36	compound	_	_
36	synthesis	synthesis	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	5	punct	_	_
38	and	and	CC	CC	_	5	cc	_	_
39	suggest	suggest	VBP	VBP	_	5	conj	_	_
40	a	a	DT	DT	_	42	det	_	_
41	novel	novel	JJ	JJ	_	42	amod	_	_
42	mechanism	mechanism	NN	NN	_	39	dobj	_	_
43	by	by	IN	IN	_	44	case	_	_
44	which	which	WDT	WDT	_	48	nmod	_	_
45	anti-inflammatory	anti-inflammatory	JJ	JJ	_	46	amod	_	_
46	corticosteroids	corticosteroid	NNS	NNS	_	48	nsubj	_	_
47	may	may	MD	MD	_	48	aux	_	_
48	inhibit	inhibit	VB	VB	_	42	acl:relcl	_	_
49	leukocyte	leukocyte	NN	NN	_	50	compound	_	_
50	accumulation	accumulation	NN	NN	_	48	dobj	_	_
51	.	.	.	.	_	1	punct	_	_

1	Bcl-2	bcl-2	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	bufalin-induced	bufalin-induced	JJ	JJ	_	5	amod	_	_
5	apoptosis	apoptosis	NN	NN	_	3	dobj	_	_
6	through	through	IN	IN	_	7	case	_	_
7	inhibition	inhibition	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	mitogen-activated	mitogen-activated	JJ	JJ	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	leukemia	leukemia	NN	NN	_	17	compound	_	_
16	U937	u937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	previous	previous	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	22	mark	_	_
9	bufalin	bufalin	NN	NN	_	22	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	15	nsubj	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	an	a	DT	DT	_	15	det	_	_
14	active	active	JJ	JJ	_	15	amod	_	_
15	principle	principle	NN	NN	_	9	acl:relcl	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Chinese	chinese	NN	NN	_	18	compound	_	_
18	medicine	medicine	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	chan'su	chan'su	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	9	punct	_	_
22	caused	cause	VBD	VBD	_	7	ccomp	_	_
23	apoptosis	apoptosis	NN	NN	_	22	dobj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	leukemia	leukemia	NN	NN	_	28	compound	_	_
27	U937	u937	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	22	nmod	_	_
29	by	by	IN	IN	_	31	case	_	_
30	anomalous	anomalous	JJ	JJ	_	31	amod	_	_
31	activation	activation	NN	NN	_	22	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	mitogen-activated	mitogen-activated	JJ	JJ	_	35	amod	_	_
34	protein	protein	NN	NN	_	35	compound	_	_
35	kinase	kinase	NN	NN	_	31	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	MAPK	mapk	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	via	via	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	signaling	signaling	NN	NN	_	42	compound	_	_
42	pathway	pathway	NN	NN	_	31	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	Ras	ras	NN	NN	_	42	nmod	_	_
45	,	,	,	,	_	44	punct	_	_
46	Raf-1	raf-1	NN	NN	_	44	conj	_	_
47	,	,	,	,	_	44	punct	_	_
48	and	and	CC	CC	_	44	cc	_	_
49	MAPK	mapk	NN	NN	_	50	compound	_	_
50	kinase-1	kinase-1	NN	NN	_	44	conj	_	_
51	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	overexpression	overexpression	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	bcl-2	bcl-2	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	U937	u937	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	on	on	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	6	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	apoptosis	apoptosis	NN	NN	_	17	nmod	_	_
20	that	that	WDT	WDT	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	induced	induce	VBN	VBN	_	19	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	bufalin	bufalin	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	apoptosis	apoptosis	NN	NN	_	15	nsubjpass	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	bufalin	bufalin	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	significantly	significantly	RB	RB	_	15	advmod	_	_
15	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	overexpression	overexpression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Bcl-2	bcl-2	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	difference	difference	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	MAPK	mapk	NN	NN	_	11	compound	_	_
11	kinase-1	kinase-1	NN	NN	_	8	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	8	acl:relcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	bufalin	bufalin	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	wild-type	wild-type	JJ	JJ	_	14	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Bcl-2-overexpressed	bcl-2-overexpressed	JJ	JJ	_	22	amod	_	_
21	U937	u937	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	conj	_	_
23	;	;	:	:	_	5	punct	_	_
24	however	however	RB	RB	_	34	advmod	_	_
25	,	,	,	,	_	34	punct	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	34	nsubjpass	_	_
28	of	of	IN	IN	_	29	case	_	_
29	MAPK	mapk	NN	NN	_	27	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	bufalin	bufalin	NN	NN	_	27	nmod	_	_
32	was	be	VBD	VBD	_	34	auxpass	_	_
33	significantly	significantly	RB	RB	_	34	advmod	_	_
34	attenuated	attenuate	VBN	VBN	_	5	parataxis	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	overexpressing	overexpress	VBG	VBG	_	37	acl	_	_
39	Bcl-2	bcl-2	NN	NN	_	38	dobj	_	_
40	.	.	.	.	_	5	punct	_	_

1	Bufalin	bufalin	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	activated	activate	VBD	VBD	_	0	root	_	_
4	activator	activator	NN	NN	_	7	compound	_	_
5	protein-1	protein-1	NN	NN	_	7	compound	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	3	dobj	_	_
8	;	;	:	:	_	3	punct	_	_
9	however	however	RB	RB	_	14	advmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	this	this	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	decreased	decrease	VBN	VBN	_	3	parataxis	_	_
15	to	to	TO	TO	_	17	case	_	_
16	40	40	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	bcl-2-overexpressed	bcl-2-overexpressed	JJ	JJ	_	21	amod	_	_
20	U937	u937	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Bcl-2	bcl-2	NN	NN	_	6	nsubj	_	_
6	acts	act	VBZ	VBZ	_	3	ccomp	_	_
7	downstream	downstream	RB	RB	_	11	advmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	MAPK	mapk	NN	NN	_	10	compound	_	_
10	kinase-1	kinase-1	NN	NN	_	7	nmod	_	_
11	but	but	CC	CC	_	6	advmod	_	_
12	upstream	upstream	RB	RB	_	11	advmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	MAPK	mapk	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	suggest	suggest	VBP	VBP	_	3	conj	_	_
17	that	that	IN	IN	_	39	mark	_	_
18	,	,	,	,	_	39	punct	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	39	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	apoptotic	apoptotic	JJ	JJ	_	26	amod	_	_
26	process	process	NN	NN	_	22	nmod	_	_
27	induced	induce	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	29	case	_	_
29	bufalin	bufalin	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	39	punct	_	_
31	the	the	DT	DT	_	33	det	_	_
32	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
33	activity	activity	NN	NN	_	39	nsubjpass	_	_
34	of	of	IN	IN	_	36	case	_	_
35	activator	activator	NN	NN	_	36	compound	_	_
36	protein-1	protein-1	NN	NN	_	33	nmod	_	_
37	may	may	MD	MD	_	39	aux	_	_
38	be	be	VB	VB	_	39	auxpass	_	_
39	down-regulated	down-regulate	VBN	VBN	_	16	ccomp	_	_
40	through	through	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	inhibition	inhibition	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	MAPK	mapk	NN	NN	_	45	compound	_	_
45	activity	activity	NN	NN	_	42	nmod	_	_
46	by	by	IN	IN	_	47	case	_	_
47	Bcl-2	bcl-2	NN	NN	_	42	nmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	2	compound	_	_
2	A	a	NN	NN	_	3	nsubj	_	_
3	interferes	interfere	VBZ	VBZ	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inducible	inducible	JJ	JJ	_	7	amod	_	_
7	degradation	degradation	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	inhibitors	inhibitor	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	but	but	CC	CC	_	7	cc	_	_
14	not	not	RB	RB	_	17	neg	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	processing	processing	NN	NN	_	7	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	p105/NF-kappa	p105/nf-kappa	NN	NN	_	20	compound	_	_
20	B1	b1	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	3	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	6	nsubj	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	3	dep	_	_
6	controls	control	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	induction	induction	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	numerous	numerous	JJ	JJ	_	12	amod	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	promoters	promoter	NNS	NNS	_	8	nmod	_	_
13	during	during	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	immunosuppressants	immunosuppressant	NNS	NNS	_	1	nmod	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	8	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CsA	csa	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	FK506	fk506	NN	NN	_	10	conj	_	_
16	exerts	exert	VBZ	VBZ	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	suppressive	suppressive	JJ	JJ	_	19	amod	_	_
19	effect	effect	NN	NN	_	16	dobj	_	_
20	on	on	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	induction	induction	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	these	these	DT	DT	_	28	det	_	_
25	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
26	B-controlled	b-controlled	JJ	JJ	_	28	amod	_	_
27	cytokine	cytokine	NN	NN	_	28	compound	_	_
28	promoters	promoter	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	for	for	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	Jurkat	jurkat	NN	NN	_	8	compound	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	leukemia	leukemia	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	as	as	RB	RB	_	8	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	human	human	JJ	JJ	_	8	conj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	mouse	mouse	NN	NN	_	13	conj	_	_
16	primary	primary	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	13	dep	_	_
19	,	,	,	,	_	2	punct	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	this	this	DT	DT	_	23	det	_	_
22	inhibitory	inhibitory	JJ	JJ	_	23	amod	_	_
23	effect	effect	NN	NN	_	25	nsubjpass	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	accompanied	accompany	VBN	VBN	_	2	ccomp	_	_
26	by	by	IN	IN	_	30	case	_	_
27	an	a	DT	DT	_	30	det	_	_
28	impaired	impaired	JJ	JJ	_	30	amod	_	_
29	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
30	translocation	translocation	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	Rel	rel	NN	NN	_	34	compound	_	_
34	proteins	protein	NNS	NNS	_	30	nmod	_	_
35	c-Rel	c-rel	NN	NN	_	34	dep	_	_
36	,	,	,	,	_	35	punct	_	_
37	RelA/p65	rela/p65	NN	NN	_	35	conj	_	_
38	and	and	CC	CC	_	35	cc	_	_
39	NF-kappa	nf-kappa	NN	NN	_	40	compound	_	_
40	B1/p50	b1/p50	NN	NN	_	35	conj	_	_
41	,	,	,	,	_	25	punct	_	_
42	whereas	whereas	IN	IN	_	48	mark	_	_
43	the	the	DT	DT	_	45	det	_	_
44	nuclear	nuclear	JJ	JJ	_	45	amod	_	_
45	appearance	appearance	NN	NN	_	48	nsubj	_	_
46	of	of	IN	IN	_	47	case	_	_
47	RelB	relb	NN	NN	_	45	nmod	_	_
48	remains	remain	VBZ	VBZ	_	25	advcl	_	_
49	unaffected	unaffected	JJ	JJ	_	48	xcomp	_	_
50	.	.	.	.	_	2	punct	_	_

1	CsA	csa	NN	NN	_	4	nsubj	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	interfere	interfere	VB	VB	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	synthesis	synthesis	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Rel	rel	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	but	but	CC	CC	_	4	cc	_	_
13	prevents	prevent	VBZ	VBZ	_	4	conj	_	_
14	the	the	DT	DT	_	16	det	_	_
15	inducible	inducible	JJ	JJ	_	16	amod	_	_
16	degradation	degradation	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	cytosolic	cytosolic	JJ	JJ	_	21	amod	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	inhibitors	inhibitor	NNS	NNS	_	16	nmod	_	_
22	I	i	NN	NN	_	25	compound	_	_
23	kappa	kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	21	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	I	i	NN	NN	_	30	compound	_	_
28	kappa	kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	beta	beta	NN	NN	_	25	conj	_	_
31	upon	upon	IN	IN	_	34	case	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	13	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	CsA	csa	NN	NN	_	0	root	_	_
2	neither	neither	CC	CC	_	1	dep	_	_
3	inhibits	inhibit	VBZ	VBZ	_	1	conj	_	_
4	the	the	DT	DT	_	5	det	_	_
5	processing	processing	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
9	B1	b1	NN	NN	_	10	compound	_	_
10	precursor	precursor	NN	NN	_	5	nmod	_	_
11	p105	p105	NN	NN	_	10	dep	_	_
12	to	to	TO	TO	_	13	case	_	_
13	p50	p50	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	nor	nor	CC	CC	_	1	cc	_	_
16	does	do	VBZ	VBZ	_	19	aux	_	_
17	it	it	PRP	PRP	_	19	nsubj	_	_
18	``	``	``	``	_	19	punct	_	_
19	stabilize	stabilize	VB	VB	_	1	conj	_	_
20	the	the	DT	DT	_	22	det	_	_
21	C-terminal	c-terminal	JJ	JJ	_	22	amod	_	_
22	portion	portion	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p105	p105	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	22	punct	_	_
26	I	i	NN	NN	_	29	compound	_	_
27	kappa	kappa	NN	NN	_	29	compound	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	gamma	gamma	NN	NN	_	22	appos	_	_
30	,	,	,	,	_	22	punct	_	_
31	which	which	WDT	WDT	_	33	nsubjpass	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	degraded	degrade	VBN	VBN	_	22	acl:relcl	_	_
34	during	during	IN	IN	_	36	case	_	_
35	p105	p105	NN	NN	_	36	compound	_	_
36	processing	processing	NN	NN	_	33	nmod	_	_
37	to	to	TO	TO	_	39	case	_	_
38	mature	mature	JJ	JJ	_	39	amod	_	_
39	p50	p50	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	CsA	csa	NN	NN	_	6	nsubj	_	_
6	interferes	interfere	VBZ	VBZ	_	3	ccomp	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	event	event	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	signal-induced	signal-induced	JJ	JJ	_	14	amod	_	_
14	degradation	degradation	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	I	i	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	I	i	NN	NN	_	24	compound	_	_
22	kappa	kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	beta	beta	NN	NN	_	19	conj	_	_
25	,	,	,	,	_	6	punct	_	_
26	but	but	CC	CC	_	6	cc	_	_
27	does	do	VBZ	VBZ	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	affect	affect	VB	VB	_	6	conj	_	_
30	the	the	DT	DT	_	31	det	_	_
31	processing	processing	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	NF-kappa	nf-kappa	NN	NN	_	34	compound	_	_
34	B1/p105	b1/p105	NN	NN	_	31	nmod	_	_
35	to	to	TO	TO	_	36	case	_	_
36	p50	p50	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Critical	critical	JJ	JJ	_	3	amod	_	_
2	cytoplasmic	cytoplasmic	JJ	JJ	_	3	amod	_	_
3	domains	domain	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	interleukin-9	interleukin-9	NN	NN	_	9	compound	_	_
7	receptor	receptor	NN	NN	_	9	compound	_	_
8	alpha	alpha	NN	NN	_	9	compound	_	_
9	chain	chain	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	interleukin-9-mediated	interleukin-9-mediated	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	3	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	signal	signal	NN	NN	_	16	compound	_	_
16	transduction	transduction	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Interleukin-9	interleukin-9	NN	NN	_	6	compound	_	_
2	receptor	receptor	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	IL-9R	il-9r	NN	NN	_	6	compound	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	complex	complex	NN	NN	_	7	nsubj	_	_
7	consists	consist	VBZ	VBZ	_	0	root	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	ligand-specific	ligand-specific	JJ	JJ	_	12	amod	_	_
11	alpha	alpha	NN	NN	_	12	compound	_	_
12	chain	chain	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL-2R	il-2r	NN	NN	_	16	compound	_	_
15	gamma	gamma	NN	NN	_	16	compound	_	_
16	chain	chain	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	two	two	CD	CD	_	6	nummod	_	_
6	regions	region	NNS	NNS	_	15	nsubjpass	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	IL-9Ralpha	il-9ralpha	NN	NN	_	10	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	important	important	JJ	JJ	_	15	xcomp	_	_
19	for	for	IN	IN	_	22	case	_	_
20	IL-9-mediated	il-9-mediated	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	growth	growth	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	membrane-proximal	membrane-proximal	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	11	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	contains	contain	VBZ	VBZ	_	3	acl:relcl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	BOX1	box1	NN	NN	_	9	compound	_	_
8	consensus	consensus	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	5	dobj	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	IL-9-induced	il-9-induced	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	Janus	janus	NN	NN	_	21	compound	_	_
21	kinases	kinase	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	JAKs	jak	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	11	punct	_	_

1	Deletion	deletion	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	region	region	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	1	cc	_	_
6	internal	internal	JJ	JJ	_	7	amod	_	_
7	deletion	deletion	NN	NN	_	1	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	BOX1	box1	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	7	nmod	_	_
12	abrogated	abrogate	VBD	VBD	_	0	root	_	_
13	IL-9-induced	il-9-induced	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	signal	signal	NN	NN	_	18	compound	_	_
18	transduction	transduction	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	substitution	substitution	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	Pro-X-Pro	pro-x-pro	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	BOX1	box1	NN	NN	_	10	compound	_	_
10	motif	motif	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	Ala-X-Ala	ala-x-ala	NN	NN	_	3	nmod	_	_
13	failed	fail	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	abolish	abolish	VB	VB	_	13	xcomp	_	_
16	IL-9-induced	il-9-induced	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	proliferation	proliferation	NN	NN	_	15	dobj	_	_
19	but	but	CC	CC	_	13	cc	_	_
20	decreased	decrease	VBD	VBD	_	13	conj	_	_
21	IL-9-mediated	il-9-mediated	JJ	JJ	_	23	amod	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	JAK	jak	NN	NN	_	26	compound	_	_
26	kinases	kinase	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	insulin	insulin	NN	NN	_	30	compound	_	_
29	receptor	receptor	NN	NN	_	30	compound	_	_
30	substrate-2	substrate-2	NN	NN	_	26	conj	_	_
31	,	,	,	,	_	26	punct	_	_
32	and	and	CC	CC	_	26	cc	_	_
33	signal	signal	NN	NN	_	34	compound	_	_
34	transducer	transducer	NN	NN	_	26	conj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	activator	activator	NN	NN	_	38	compound	_	_
37	of	of	IN	IN	_	38	amod	_	_
38	transcription	transcription	NN	NN	_	34	conj	_	_
39	3	3	CD	CD	_	38	nummod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	STAT3	stat3	NN	NN	_	34	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	and	and	CC	CC	_	23	cc	_	_
44	expression	expression	NN	NN	_	23	conj	_	_
45	of	of	IN	IN	_	46	case	_	_
46	c-myc	c-myc	NN	NN	_	44	nmod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	junB	junb	NN	NN	_	46	conj	_	_
49	.	.	.	.	_	13	punct	_	_

1	Another	another	DT	DT	_	3	det	_	_
2	important	important	JJ	JJ	_	3	amod	_	_
3	region	region	NN	NN	_	4	nsubj	_	_
4	is	be	VBZ	VBZ	_	0	root	_	_
5	downstream	downstream	JJ	JJ	_	4	advmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	BOX1	box1	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	contains	contain	VBZ	VBZ	_	4	conj	_	_
12	a	a	DT	DT	_	15	det	_	_
13	STAT3	stat3	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	11	dobj	_	_
16	YLPQ	ylpq	NN	NN	_	15	dep	_	_
17	.	.	.	.	_	4	punct	_	_

1	Deletion	deletion	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	region	region	NN	NN	_	1	nmod	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	impaired	impair	VBD	VBD	_	0	root	_	_
7	IL-9-induced	il-9-induced	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	activation	activation	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	JAK	jak	NN	NN	_	14	compound	_	_
14	kinases	kinase	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	insulin	insulin	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	substrate-2	substrate-2	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	STAT3	stat3	NN	NN	_	14	conj	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	expression	expression	NN	NN	_	9	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	early	early	JJ	JJ	_	27	amod	_	_
26	response	response	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	point	point	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	9	nsubj	_	_
4	changing	change	VBG	VBG	_	3	acl	_	_
5	YLPQ	ylpq	NN	NN	_	4	dobj	_	_
6	into	into	IN	IN	_	7	case	_	_
7	YLPA	ylpa	NN	NN	_	4	nmod	_	_
8	greatly	greatly	RB	RB	_	9	advmod	_	_
9	reduced	reduce	VBD	VBD	_	0	root	_	_
10	IL-9-induced	il-9-induced	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	STAT3	stat3	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	expression	expression	NN	NN	_	11	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	c-myc	c-myc	NN	NN	_	15	nmod	_	_
18	but	but	CC	CC	_	9	cc	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	affect	affect	VB	VB	_	9	conj	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	proliferation	proliferation	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	cooperation	cooperation	NN	NN	_	21	nsubj	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	cross-talk	cross-talk	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	signaling	signal	VBG	VBG	_	10	amod	_	_
10	molecules	molecule	NNS	NNS	_	5	nmod	_	_
11	associated	associate	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	different	different	JJ	JJ	_	14	amod	_	_
14	domains	domain	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-9Ralpha	il-9ralpha	NN	NN	_	14	nmod	_	_
17	other	other	JJ	JJ	_	16	cc	_	_
18	than	than	IN	IN	_	17	dep	_	_
19	STAT3	stat3	NN	NN	_	16	conj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	essential	essential	JJ	JJ	_	3	ccomp	_	_
22	for	for	IN	IN	_	25	case	_	_
23	IL-9-mediated	il-9-mediated	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	growth	growth	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
5	virus	virus	NN	NN	_	8	compound	_	_
6	type	type	NN	NN	_	8	compound	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	replication	replication	NN	NN	_	1	nmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	novel	novel	JJ	JJ	_	14	amod	_	_
14	combination	combination	NN	NN	_	1	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	anti-Tat	anti-tat	JJ	JJ	_	18	amod	_	_
17	single-chain	single-chain	JJ	JJ	_	18	amod	_	_
18	intrabodies	intrabody	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	antagonists	antagonist	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	9	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
3	virus	virus	NN	NN	_	9	compound	_	_
4	type	type	NN	NN	_	9	compound	_	_
5	1	1	CD	CD	_	9	nummod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	Tat	tat	NN	NN	_	25	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	an	a	DT	DT	_	14	det	_	_
12	early	early	JJ	JJ	_	14	amod	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	protein	protein	NN	NN	_	9	appos	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	critical	critical	JJ	JJ	_	14	acl:relcl	_	_
18	for	for	IN	IN	_	20	case	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	gene	gene	NN	NN	_	17	nmod	_	_
21	expression	expression	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	replication	replication	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	9	punct	_	_
25	transactivates	transactivate	VBZ	VBZ	_	0	root	_	_
26	the	the	DT	DT	_	30	det	_	_
27	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
28	long	long	JJ	JJ	_	30	amod	_	_
29	terminal	terminal	JJ	JJ	_	30	amod	_	_
30	repeat	repeat	NN	NN	_	25	dobj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	LTR	ltr	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	via	via	IN	IN	_	36	case	_	_
35	its	its	PRP$	PRP$	_	36	nmod:poss	_	_
36	binding	binding	NN	NN	_	25	nmod	_	_
37	to	to	TO	TO	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	transactivation	transactivation	NN	NN	_	41	compound	_	_
40	response	response	NN	NN	_	41	compound	_	_
41	element	element	NN	NN	_	36	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	TAR	tar	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	and	and	CC	CC	_	25	cc	_	_
46	,	,	,	,	_	25	punct	_	_
47	along	along	IN	IN	_	51	case	_	_
48	with	with	IN	IN	_	51	case	_	_
49	other	other	JJ	JJ	_	51	amod	_	_
50	cellular	cellular	JJ	JJ	_	51	amod	_	_
51	factors	factor	NNS	NNS	_	25	nmod	_	_
52	,	,	,	,	_	25	punct	_	_
53	increases	increase	VBZ	VBZ	_	25	dep	_	_
54	viral	viral	JJ	JJ	_	55	amod	_	_
55	transcription	transcription	NN	NN	_	53	dobj	_	_
56	initiation	initiation	NN	NN	_	55	dep	_	_
57	and	and	CC	CC	_	55	cc	_	_
58	elongation	elongation	NN	NN	_	55	conj	_	_
59	.	.	.	.	_	25	punct	_	_

1	Tat	tat	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	superactivates	superactivate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	3	dobj	_	_
7	through	through	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	TAR-independent	tar-independent	JJ	JJ	_	10	amod	_	_
10	mechanism	mechanism	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	including	include	VBG	VBG	_	25	case	_	_
13	tumor	tumor	NN	NN	_	16	nmod:npmod	_	_
14	necrosis	necrosis	NN	NN	_	16	nmod:npmod	_	_
15	factor	factor	NN	NN	_	16	nmod:npmod	_	_
16	alpha-induced	alpha-induced	JJ	JJ	_	25	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	protein	protein	NN	NN	_	24	nmod:npmod	_	_
19	kinase	kinase	NN	NN	_	24	nmod:npmod	_	_
20	C	c	NN	NN	_	24	nmod:npmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	PKC	pkc	NN	NN	_	24	dep	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	-dependent	-dependent	JJ	JJ	_	16	conj	_	_
25	activation	activation	NN	NN	_	10	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	3	punct	_	_
30	and	and	CC	CC	_	3	cc	_	_
31	inhibitors	inhibitor	NNS	NNS	_	38	nsubj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	Tat	tat	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	NF-kappa	nf-kappa	NN	NN	_	36	compound	_	_
36	B	b	NN	NN	_	33	conj	_	_
37	cooperatively	cooperatively	RB	RB	_	38	advmod	_	_
38	down-regulate	down-regulate	VBP	VBP	_	3	conj	_	_
39	this	this	DT	DT	_	42	det	_	_
40	Tat-mediated	tat-mediated	JJ	JJ	_	42	amod	_	_
41	LTR	ltr	NN	NN	_	42	compound	_	_
42	superactivation	superactivation	NN	NN	_	38	dobj	_	_
43	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	40	nmod	_	_
4	,	,	,	,	_	40	punct	_	_
5	a	a	DT	DT	_	10	det	_	_
6	combined	combined	JJ	JJ	_	10	amod	_	_
7	pharmacologic	pharmacologic	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	genetic	genetic	JJ	JJ	_	7	conj	_	_
10	strategy	strategy	NN	NN	_	40	nsubjpass	_	_
11	using	use	VBG	VBG	_	10	acl	_	_
12	two	two	CD	CD	_	18	nummod	_	_
13	PKC	pkc	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	inhibitors	inhibitor	NNS	NNS	_	11	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	pentoxifylline	pentoxifylline	NN	NN	_	18	appos	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	PTX	ptx	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	Go-6976	go-6976	NN	NN	_	20	conj	_	_
26	,	,	,	,	_	10	punct	_	_
27	and	and	CC	CC	_	10	cc	_	_
28	a	a	DT	DT	_	34	det	_	_
29	stably	stably	RB	RB	_	30	advmod	_	_
30	expressed	express	VBN	VBN	_	34	amod	_	_
31	anti-Tat	anti-tat	JJ	JJ	_	34	amod	_	_
32	single-chain	single-chain	JJ	JJ	_	34	amod	_	_
33	intracellular	intracellular	JJ	JJ	_	34	amod	_	_
34	antibody	antibody	NN	NN	_	10	conj	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	sFv	sfv	NN	NN	_	37	compound	_	_
37	intrabody	intrabody	NN	NN	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	was	be	VBD	VBD	_	40	auxpass	_	_
40	employed	employ	VBN	VBN	_	0	root	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	obtain	obtain	VB	VB	_	40	xcomp	_	_
43	cooperative	cooperative	JJ	JJ	_	44	amod	_	_
44	inhibition	inhibition	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	50	case	_	_
46	both	both	CC	CC	_	50	cc:preconj	_	_
47	HIV-1	hiv-1	NN	NN	_	50	compound	_	_
48	LTR-driven	ltr-driven	JJ	JJ	_	50	amod	_	_
49	gene	gene	NN	NN	_	50	compound	_	_
50	expression	expression	NN	NN	_	44	nmod	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	HIV-1	hiv-1	NN	NN	_	53	compound	_	_
53	replication	replication	NN	NN	_	50	conj	_	_
54	.	.	.	.	_	40	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	PTX	ptx	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Go-6976	go-6976	NN	NN	_	5	conj	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cooperative	cooperative	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	both	both	CC	CC	_	17	cc:preconj	_	_
14	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
15	LTR-driven	ltr-driven	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	replication	replication	NN	NN	_	17	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	combined	combined	JJ	JJ	_	6	amod	_	_
6	use	use	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	anti-Tat	anti-tat	JJ	JJ	_	10	amod	_	_
9	sFv	sfv	NN	NN	_	10	compound	_	_
10	intrabodies	intrabody	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	16	det	_	_
13	two	two	CD	CD	_	16	nummod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	inhibitors	inhibitor	NNS	NNS	_	10	conj	_	_
17	retained	retain	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	virus	virus	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	latent	latent	JJ	JJ	_	23	amod	_	_
23	state	state	NN	NN	_	17	nmod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	as	as	RB	RB	_	26	advmod	_	_
26	long	long	JJ	JJ	_	17	nmod	_	_
27	as	as	IN	IN	_	29	case	_	_
28	45	45	CD	CD	_	29	nummod	_	_
29	days	day	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	combined	combined	JJ	JJ	_	3	amod	_	_
3	treatment	treatment	NN	NN	_	4	nsubj	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	durable	durable	JJ	JJ	_	8	amod	_	_
8	inhibition	inhibition	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	replication	replication	NN	NN	_	8	nmod	_	_
12	than	than	IN	IN	_	14	mark	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	seen	see	VBN	VBN	_	8	dep	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	inhibitors	inhibitor	NNS	NNS	_	14	nmod	_	_
20	alone	alone	RB	RB	_	19	advmod	_	_
21	or	or	CC	CC	_	19	cc	_	_
22	the	the	DT	DT	_	25	det	_	_
23	anti-Tat	anti-tat	NN	NN	_	25	compound	_	_
24	sFv	sfv	NN	NN	_	25	compound	_	_
25	intrabodies	intrabody	NNS	NNS	_	19	conj	_	_
26	alone	alone	RB	RB	_	25	advmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	26	mark	_	_
7	in	in	IN	IN	_	12	case	_	_
8	future	future	JJ	JJ	_	12	amod	_	_
9	clinical	clinical	JJ	JJ	_	8	dep	_	_
10	gene	gene	NN	NN	_	12	compound	_	_
11	therapy	therapy	NN	NN	_	12	compound	_	_
12	trials	trial	NNS	NNS	_	26	nmod	_	_
13	,	,	,	,	_	26	punct	_	_
14	a	a	DT	DT	_	19	det	_	_
15	combined	combined	JJ	JJ	_	19	amod	_	_
16	pharmacologic	pharmacologic	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	genetic	genetic	JJ	JJ	_	16	conj	_	_
19	strategy	strategy	NN	NN	_	26	nsubj	_	_
20	like	like	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	one	one	CD	CD	_	19	nmod	_	_
23	reported	report	VBN	VBN	_	22	acl	_	_
24	here	here	RB	RB	_	23	advmod	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	improve	improve	VB	VB	_	5	ccomp	_	_
27	the	the	DT	DT	_	28	det	_	_
28	survival	survival	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	transduced	transduce	VBN	VBN	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	26	cc	_	_
33	prolong	prolong	VB	VB	_	26	conj	_	_
34	clinical	clinical	JJ	JJ	_	35	amod	_	_
35	benefit	benefit	NN	NN	_	33	dobj	_	_
36	.	.	.	.	_	5	punct	_	_

1	CholecystokininB	cholecystokininb	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	10	nsubjpass	_	_
3	from	from	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	Jurkat	jurkat	NN	NN	_	8	compound	_	_
6	lymphoblastic	lymphoblastic	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	activator	activator	NN	NN	_	15	compound	_	_
13	protein-1-responsive	protein-1-responsive	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	analyze	analyze	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	cholecystokinin	cholecystokinin	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	CCK(B)	cck(b)	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	receptor	receptor	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	22	case	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	lymphoblastic	lymphoblastic	JJ	JJ	_	22	amod	_	_
20	Jurkat	jurkat	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	trophic	trophic	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	dobj	_	_
6	resulting	result	VBG	VBG	_	5	acl	_	_
7	from	from	IN	IN	_	8	case	_	_
8	activation	activation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	such	such	JJ	JJ	_	12	amod	_	_
11	a	a	DT	DT	_	12	det	_	_
12	receptor	receptor	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	using	use	VBG	VBG	_	2	advcl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	strategy	strategy	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	transiently	transiently	RB	RB	_	7	advmod	_	_
7	transfected	transfect	VBN	VBN	_	0	root	_	_
8	Jurkat	jurkat	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	dobj	_	_
11	with	with	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	reporter	reporter	NN	NN	_	16	compound	_	_
14	plasmid	plasmid	NN	NN	_	16	compound	_	_
15	p	p	NN	NN	_	16	compound	_	_
16	-LSB-(TRE)3-tk-Luc-RSB-	-lsb-(tre)3-tk-luc-rsb-	NN	NN	_	7	nmod	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	found	find	VBD	VBD	_	7	conj	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	CCK-8	cck-8	NN	NN	_	22	nsubj	_	_
21	was	be	VBD	VBD	_	22	cop	_	_
22	able	able	JJ	JJ	_	18	ccomp	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	dose-dependently	dose-dependently	RB	RB	_	25	advmod	_	_
25	induce	induce	VB	VB	_	22	xcomp	_	_
26	luciferase	luciferase	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	25	dobj	_	_
28	related	related	JJ	JJ	_	27	amod	_	_
29	to	to	TO	TO	_	35	case	_	_
30	activator	activator	NN	NN	_	31	compound	_	_
31	protein-1	protein-1	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	AP-1	ap-1	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	activation	activation	NN	NN	_	28	nmod	_	_
36	with	with	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	maximal	maximal	JJ	JJ	_	39	amod	_	_
39	response	response	NN	NN	_	25	nmod	_	_
40	identical	identical	JJ	JJ	_	39	amod	_	_
41	to	to	TO	TO	_	42	case	_	_
42	that	that	DT	DT	_	40	nmod	_	_
43	obtained	obtain	VBN	VBN	_	42	acl	_	_
44	with	with	IN	IN	_	45	case	_	_
45	compounds	compound	NNS	NNS	_	43	nmod	_	_
46	known	know	VBN	VBN	_	45	acl	_	_
47	to	to	TO	TO	_	48	mark	_	_
48	activate	activate	VB	VB	_	46	xcomp	_	_
49	AP-1	ap-1	NN	NN	_	50	compound	_	_
50	complex	complex	NN	NN	_	48	dobj	_	_
51	(	(	-LRB-	-LRB-	_	60	punct	_	_
52	quantitatively	quantitatively	RB	RB	_	60	advmod	_	_
53	,	,	,	,	_	60	punct	_	_
54	the	the	DT	DT	_	56	det	_	_
55	same	same	JJ	JJ	_	56	amod	_	_
56	level	level	NN	NN	_	60	nsubjpass	_	_
57	of	of	IN	IN	_	58	case	_	_
58	induction	induction	NN	NN	_	56	nmod	_	_
59	was	be	VBD	VBD	_	60	auxpass	_	_
60	obtained	obtain	VBN	VBN	_	22	dep	_	_
61	with	with	IN	IN	_	64	case	_	_
62	1	1	CD	CD	_	63	compound	_	_
63	nM	nm	NN	NN	_	64	amod	_	_
64	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	60	nmod	_	_
65	,	,	,	,	_	64	punct	_	_
66	100	100	CD	CD	_	67	compound	_	_
67	microM	microm	NN	NN	_	68	amod	_	_
68	diacylglycerol	diacylglycerol	NN	NN	_	64	conj	_	_
69	,	,	,	,	_	64	punct	_	_
70	or	or	CC	CC	_	64	cc	_	_
71	4	4	CD	CD	_	72	compound	_	_
72	nM	nm	NN	NN	_	75	amod	_	_
73	epidermal	epidermal	JJ	JJ	_	75	amod	_	_
74	growth	growth	NN	NN	_	75	compound	_	_
75	factor	factor	NN	NN	_	64	conj	_	_
76	)	)	-RRB-	-RRB-	_	60	punct	_	_
77	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CCK(B)	cck(b)	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	such	such	JJ	JJ	_	10	amod	_	_
9	a	a	DT	DT	_	10	det	_	_
10	stimulation	stimulation	NN	NN	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	inhibiting	inhibiting	NN	NN	_	16	compound	_	_
16	effect	effect	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	selective	selective	JJ	JJ	_	22	amod	_	_
20	CCK(B)	cck(b)	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	antagonist	antagonist	NN	NN	_	16	nmod	_	_
23	PD-135,158	pd-135,158	NN	NN	_	22	dep	_	_
24	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	confirmed	confirm	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	COS-7	cos-7	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	transfected	transfect	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cDNA	cdna	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	CCK(B)	cck(b)	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	11	nmod	_	_
15	cloned	clone	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	19	case	_	_
17	Jurkat	jurkat	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	AP-1-dependent	ap-1-dependent	JJ	JJ	_	7	amod	_	_
6	luciferase	luciferase	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	Jurkat	jurkat	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	tested	test	VBD	VBD	_	3	parataxis	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	specific	specific	JJ	JJ	_	17	amod	_	_
17	inhibitors	inhibitor	NNS	NNS	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	serine/threonine	serine/threonine	NN	NN	_	20	compound	_	_
20	phosphatases-1	phosphatases-1	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	-2A	-2a	NN	NN	_	20	conj	_	_
23	:	:	:	:	_	3	punct	_	_
24	okadaic	okadaic	JJ	JJ	_	25	amod	_	_
25	acid	acid	NN	NN	_	3	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	calyculin	calyculin	NN	NN	_	28	compound	_	_
28	A	a	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	compounds	compound	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	phorbol-12-myristate-13-acetate	phorbol-12-myristate-13-acetate	NN	NN	_	7	compound	_	_
7	response	response	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	4	punct	_	_
9	whereas	whereas	IN	IN	_	13	mark	_	_
10	we	we	PRP	PRP	_	13	nsubj	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	observed	observe	VBN	VBN	_	4	advcl	_	_
14	a	a	DT	DT	_	15	det	_	_
15	contribution	contribution	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	phosphatase	phosphatase	NN	NN	_	18	compound	_	_
18	inhibitors	inhibitor	NNS	NNS	_	15	nmod	_	_
19	on	on	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	CCK-8-induced	cck-8-induced	JJ	JJ	_	23	amod	_	_
22	luciferase	luciferase	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	confirm	confirm	VB	VB	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	CCK(B)	cck(b)	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	2	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	response	response	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	investigated	investigate	VBD	VBD	_	2	parataxis	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CCK-8	cck-8	NN	NN	_	16	compound	_	_
16	effect	effect	NN	NN	_	13	dobj	_	_
17	on	on	IN	IN	_	19	case	_	_
18	interleukin-2	interleukin-2	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	a	a	DT	DT	_	24	det	_	_
22	natural	natural	JJ	JJ	_	24	amod	_	_
23	endogenous	endogenous	JJ	JJ	_	24	amod	_	_
24	gene	gene	NN	NN	_	13	dep	_	_
25	regulated	regulate	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	several	several	JJ	JJ	_	28	amod	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	including	include	VBG	VBG	_	31	case	_	_
31	AP-1	ap-1	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	Jurkat	jurkat	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	12	nmod	_	_
5	activated	activate	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	phorbol-12-myristate-13-acetate	phorbol-12-myristate-13-acetate	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	phytohemagglutinin	phytohemagglutinin	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	12	punct	_	_
11	CCK-8	cck-8	NN	NN	_	12	nsubj	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	abolished	abolish	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	PD-135,158	pd-135,158	NN	NN	_	4	nmod	_	_
7	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	CCK-8	cck-8	NN	NN	_	6	nsubj	_	_
6	exerts	exert	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	trophic	trophic	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Jurkat	jurkat	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	through	through	IN	IN	_	15	case	_	_
15	stimulation	stimulation	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	CCK(B)	cck(b)	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	15	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	modulation	modulation	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	expression	expression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	AP-1-regulated	ap-1-regulated	JJ	JJ	_	25	amod	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	6	nsubj	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	5	case	_	_
5	CD21	cd21	NN	NN	_	3	nmod	_	_
6	activates	activate	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	initial	initial	JJ	JJ	_	10	amod	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	promoter	promoter	NN	NN	_	6	dobj	_	_
11	via	via	IN	IN	_	13	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	an	a	DT	DT	_	10	det	_	_
8	oncogenic	oncogenic	JJ	JJ	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	herpesvirus	herpesvirus	NN	NN	_	2	appos	_	_
11	,	,	,	,	_	2	punct	_	_
12	binds	bind	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	12	nmod	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	infects	infect	VBZ	VBZ	_	12	conj	_	_
16	normal	normal	JJ	JJ	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	dobj	_	_
20	via	via	IN	IN	_	21	case	_	_
21	CD21	cd21	NN	NN	_	15	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	the	the	DT	DT	_	26	det	_	_
24	CR2	cr2	NN	NN	_	26	compound	_	_
25	complement	complement	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	21	appos	_	_
27	.	.	.	.	_	12	punct	_	_

1	Studies	study	NNS	NNS	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	enable	enable	VBP	VBP	_	4	acl:relcl	_	_
7	EBV	ebv	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	infect	infect	VB	VB	_	6	xcomp	_	_
10	nonactivated	nonactivated	JJ	JJ	_	14	amod	_	_
11	,	,	,	,	_	14	punct	_	_
12	noncycling	noncycling	JJ	JJ	_	14	amod	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	dobj	_	_
15	provide	provide	VBP	VBP	_	0	root	_	_
16	compelling	compelling	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	sequence	sequence	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	events	event	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	36	nmod	_	_
25	EBV	ebv	NN	NN	_	36	nsubj	_	_
26	binding	bind	VBG	VBG	_	25	acl	_	_
27	to	to	TO	TO	_	28	case	_	_
28	CD21	cd21	NN	NN	_	26	nmod	_	_
29	on	on	IN	IN	_	34	case	_	_
30	purified	purify	VBN	VBN	_	34	amod	_	_
31	resting	rest	VBG	VBG	_	34	amod	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	rapidly	rapidly	RB	RB	_	36	advmod	_	_
36	activates	activate	VBZ	VBZ	_	20	acl:relcl	_	_
37	the	the	DT	DT	_	38	det	_	_
38	NF-kappaB	nf-kappab	NN	NN	_	36	dobj	_	_
39	transcription	transcription	NN	NN	_	40	compound	_	_
40	factor	factor	NN	NN	_	38	dep	_	_
41	,	,	,	,	_	36	punct	_	_
42	which	which	WDT	WDT	_	47	nsubj	_	_
43	,	,	,	,	_	47	punct	_	_
44	in	in	IN	IN	_	45	case	_	_
45	turn	turn	NN	NN	_	47	nmod	_	_
46	,	,	,	,	_	47	punct	_	_
47	binds	bind	VBZ	VBZ	_	36	dep	_	_
48	to	to	TO	TO	_	45	case	_	_
49	and	and	CC	CC	_	47	cc	_	_
50	mediates	mediate	VBZ	VBZ	_	47	conj	_	_
51	transcriptional	transcriptional	JJ	JJ	_	52	amod	_	_
52	activation	activation	NN	NN	_	50	dobj	_	_
53	of	of	IN	IN	_	54	case	_	_
54	Wp	wp	NN	NN	_	52	nmod	_	_
55	,	,	,	,	_	54	punct	_	_
56	the	the	DT	DT	_	61	det	_	_
57	initial	initial	JJ	JJ	_	61	amod	_	_
58	viral	viral	JJ	JJ	_	61	amod	_	_
59	latent	latent	JJ	JJ	_	61	amod	_	_
60	gene	gene	NN	NN	_	61	compound	_	_
61	promoter	promoter	NN	NN	_	54	appos	_	_
62	.	.	.	.	_	15	punct	_	_

1	Thus	thus	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	EBV	ebv	NN	NN	_	13	nsubj	_	_
4	binding	bind	VBG	VBG	_	3	acl	_	_
5	to	to	TO	TO	_	8	case	_	_
6	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	resting	rest	VBG	VBG	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	triggers	trigger	VBZ	VBZ	_	0	root	_	_
14	an	a	DT	DT	_	18	det	_	_
15	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	18	amod	_	_
16	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	13	dobj	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	18	acl:relcl	_	_
22	for	for	IN	IN	_	23	case	_	_
23	infection	infection	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	1	nmod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	4	dep	_	_
7	by	by	IN	IN	_	9	case	_	_
8	phagocytic	phagocytic	JJ	JJ	_	9	amod	_	_
9	stimuli	stimulus	NNS	NNS	_	1	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	neutrophils	neutrophil	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Phagocytosis	phagocytosis	NN	NN	_	2	nsubj	_	_
2	represents	represent	VBZ	VBZ	_	0	root	_	_
3	an	a	DT	DT	_	6	det	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	physiological	physiological	JJ	JJ	_	4	dep	_	_
6	trigger	trigger	NN	NN	_	2	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	inducible	inducible	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	several	several	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	neutrophils	neutrophil	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	21	nsubjpass	_	_
9	primarily	primarily	RB	RB	_	10	advmod	_	_
10	consisting	consist	VBG	VBG	_	8	acl	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	classical	classical	JJ	JJ	_	16	amod	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	heterodimer	heterodimer	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	p50/RelA	p50/rela	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	8	punct	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	4	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	phagocytosing	phagocytose	VBG	VBG	_	24	amod	_	_
24	neutrophils	neutrophil	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	16	mark	_	_
11	be	be	VB	VB	_	16	cop	_	_
12	a	a	DT	DT	_	16	det	_	_
13	rapid	rapid	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	transient	transient	JJ	JJ	_	13	conj	_	_
16	response	response	NN	NN	_	9	xcomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	reaching	reach	VBG	VBG	_	16	dep	_	_
19	a	a	DT	DT	_	20	det	_	_
20	maximum	maximum	NN	NN	_	18	dobj	_	_
21	by	by	IN	IN	_	23	case	_	_
22	10-15	10-15	CD	CD	_	23	nummod	_	_
23	min	min	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	returning	return	VBG	VBG	_	18	conj	_	_
27	to	to	TO	TO	_	29	case	_	_
28	near-basal	near-basal	JJ	JJ	_	29	amod	_	_
29	levels	level	NNS	NNS	_	26	nmod	_	_
30	by	by	IN	IN	_	32	case	_	_
31	30	30	CD	CD	_	32	nummod	_	_
32	min	min	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	neutrophils	neutrophil	NNS	NNS	_	17	nmod	_	_
3	undergoing	undergo	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	phagocytosis	phagocytosis	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	opsonized	opsonized	JJ	JJ	_	8	amod	_	_
8	yeasts	yeast	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	onset	onset	NN	NN	_	17	nsubjpass	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	paralleled	parallel	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	decline	decline	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	27	case	_	_
22	immunoreactive	immunoreactive	JJ	JJ	_	27	amod	_	_
23	I	i	NN	NN	_	25	compound	_	_
24	kappa	kappa	NN	NN	_	25	compound	_	_
25	B-alpha	b-alpha	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	20	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	and	and	CC	CC	_	17	cc	_	_
30	the	the	DT	DT	_	35	det	_	_
31	cellular	cellular	JJ	JJ	_	35	amod	_	_
32	I	i	NN	NN	_	35	compound	_	_
33	kappa	kappa	NN	NN	_	35	compound	_	_
34	B-alpha	b-alpha	NN	NN	_	35	compound	_	_
35	pool	pool	NN	NN	_	37	nsubjpass	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	replenished	replenish	VBN	VBN	_	17	conj	_	_
38	by	by	IN	IN	_	40	case	_	_
39	30	30	CD	CD	_	40	nummod	_	_
40	min	min	NN	NN	_	37	nmod	_	_
41	,	,	,	,	_	37	punct	_	_
42	in	in	IN	IN	_	43	case	_	_
43	agreement	agreement	NN	NN	_	37	nmod	_	_
44	with	with	IN	IN	_	48	case	_	_
45	our	we	PRP$	PRP$	_	48	nmod:poss	_	_
46	gel	gel	NN	NN	_	48	compound	_	_
47	shift	shift	NN	NN	_	48	compound	_	_
48	data	datum	NNS	NNS	_	43	nmod	_	_
49	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	8	nsubj	_	_
7	could	could	MD	MD	_	8	aux	_	_
8	constitute	constitute	VB	VB	_	2	ccomp	_	_
9	one	one	CD	CD	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
13	whereby	whereby	IN	IN	_	21	advmod	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	21	nsubjpass	_	_
16	of	of	IN	IN	_	19	case	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B-responsive	b-responsive	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	enhanced	enhance	VBN	VBN	_	9	dep	_	_
22	in	in	IN	IN	_	24	case	_	_
23	phagocytosing	phagocytose	VBG	VBG	_	24	amod	_	_
24	neutrophils	neutrophil	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	3	case	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	knowledge	knowledge	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	this	this	DT	DT	_	6	nsubj	_	_
6	represents	represent	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	first	first	JJ	JJ	_	9	amod	_	_
9	demonstration	demonstration	NN	NN	_	6	dobj	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	phagocytic	phagocytic	JJ	JJ	_	12	amod	_	_
12	stimuli	stimulus	NNS	NNS	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	induce	induce	VB	VB	_	9	ccomp	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	neutrophils	neutrophil	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Surfactant	surfactant	JJ	JJ	_	3	amod	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	A	a	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	THP-1	thp-1	NN	NN	_	12	compound	_	_
10	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	many	many	JJ	JJ	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	for	for	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	10	nmod	_	_
8	products	product	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	2	acl:relcl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	inflammation	inflammation	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	controlled	control	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	25	case	_	_
16	the	the	DT	DT	_	25	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
18	regulator	regulator	NN	NN	_	25	compound	_	_
19	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
20	factor	factor	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	NF	nf	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	-kappa	-kappa	NN	NN	_	25	compound	_	_
25	B	b	NN	NN	_	14	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	Because	because	IN	IN	_	9	mark	_	_
2	surfactant	surfactant	JJ	JJ	_	7	amod	_	_
3	protein	protein	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	SP	sp	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	A	a	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	39	advcl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	local	local	JJ	JJ	_	13	amod	_	_
12	host	host	NN	NN	_	13	compound	_	_
13	defense	defense	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	lung	lung	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	alters	alter	VBZ	VBZ	_	9	conj	_	_
19	immune	immune	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	18	dobj	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	modulating	modulate	VBG	VBG	_	18	advcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	proinflammatory	proinflammatory	JJ	JJ	_	28	amod	_	_
28	cytokines	cytokine	NNS	NNS	_	25	nmod	_	_
29	as	as	RB	RB	_	28	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	surface	surface	NN	NN	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	28	conj	_	_
34	involved	involve	VBN	VBN	_	33	acl	_	_
35	in	in	IN	IN	_	36	case	_	_
36	inflammation	inflammation	NN	NN	_	34	nmod	_	_
37	,	,	,	,	_	39	punct	_	_
38	we	we	PRP	PRP	_	39	nsubj	_	_
39	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
40	that	that	IN	IN	_	42	mark	_	_
41	SP-A	sp-a	NN	NN	_	42	nsubj	_	_
42	exerts	exert	VBZ	VBZ	_	39	ccomp	_	_
43	its	its	PRP$	PRP$	_	44	nmod:poss	_	_
44	action	action	NN	NN	_	42	dobj	_	_
45	,	,	,	,	_	42	punct	_	_
46	at	at	IN	IN	_	49	advmod	_	_
47	least	least	JJS	JJS	_	46	mwe	_	_
48	in	in	IN	IN	_	49	case	_	_
49	part	part	NN	NN	_	42	nmod	_	_
50	,	,	,	,	_	42	punct	_	_
51	via	via	IN	IN	_	52	case	_	_
52	activation	activation	NN	NN	_	42	nmod	_	_
53	of	of	IN	IN	_	55	case	_	_
54	NF-kappa	nf-kappa	NN	NN	_	55	compound	_	_
55	B	b	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	39	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	gel	gel	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	2	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	determine	determine	VB	VB	_	2	advcl	_	_
8	whether	whether	IN	IN	_	10	mark	_	_
9	SP-A	sp-a	NN	NN	_	10	nsubj	_	_
10	activated	activate	VBD	VBD	_	7	ccomp	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	THP-1	thp-1	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	10	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	monocytic	monocytic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	line	line	NN	NN	_	17	appos	_	_
24	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	THP-1	thp-1	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	SP-A	sp-a	NN	NN	_	10	compound	_	_
10	doses	dose	NNS	NNS	_	1	nmod	_	_
11	as	as	RB	RB	_	12	advmod	_	_
12	low	low	JJ	JJ	_	10	amod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	microgram/ml	microgram/ml	NN	NN	_	12	nmod	_	_
16	occurred	occur	VBD	VBD	_	0	root	_	_
17	within	within	IN	IN	_	19	case	_	_
18	30	30	CD	CD	_	19	nummod	_	_
19	min	min	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	SP-A	sp-a	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	peaked	peak	VBD	VBD	_	16	conj	_	_
25	at	at	IN	IN	_	27	case	_	_
26	60	60	CD	CD	_	27	nummod	_	_
27	min	min	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	16	punct	_	_
29	and	and	CC	CC	_	16	cc	_	_
30	then	then	RB	RB	_	31	advmod	_	_
31	declined	decline	VBD	VBD	_	16	conj	_	_
32	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	inhibited	inhibit	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	known	known	JJ	JJ	_	7	amod	_	_
7	inhibitors	inhibitor	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	7	cc	_	_
12	by	by	IN	IN	_	14	case	_	_
13	simultaneous	simultaneous	JJ	JJ	_	14	amod	_	_
14	treatment	treatment	NN	NN	_	7	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	surfactant	surfactant	JJ	JJ	_	20	amod	_	_
20	lipids	lipid	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	inhibitors	inhibitor	NNS	NNS	_	7	nsubj	_	_
7	blocked	block	VBD	VBD	_	0	root	_	_
8	SP-A-dependent	sp-a-dependent	JJ	JJ	_	9	amod	_	_
9	increases	increase	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	15	case	_	_
11	tumor	tumor	NN	NN	_	14	compound	_	_
12	necrosis	necrosis	NN	NN	_	14	compound	_	_
13	factor-alpha	factor-alpha	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	9	nmod	_	_
8	SP-A	sp-a	NN	NN	_	9	nsubj	_	_
9	plays	play	VBZ	VBZ	_	5	acl:relcl	_	_
10	a	a	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pathogenesis	pathogenesis	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	some	some	DT	DT	_	18	det	_	_
17	lung	lung	NN	NN	_	18	compound	_	_
18	conditions	condition	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	point	point	VBP	VBP	_	3	conj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	potential	potential	JJ	JJ	_	24	amod	_	_
23	therapeutic	therapeutic	JJ	JJ	_	22	dep	_	_
24	measures	measure	NNS	NNS	_	20	nmod	_	_
25	that	that	WDT	WDT	_	28	nsubjpass	_	_
26	could	could	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	used	use	VBN	VBN	_	24	acl:relcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	prevent	prevent	VB	VB	_	28	xcomp	_	_
31	SP-A	sp-a	NN	NN	_	33	compound	_	_
32	induced	induced	JJ	JJ	_	33	amod	_	_
33	inflammation	inflammation	NN	NN	_	30	dobj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	lung	lung	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Distinct	distinct	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
3	for	for	IN	IN	_	5	case	_	_
4	N-acetylcysteine	n-acetylcysteine	NN	NN	_	5	compound	_	_
5	inhibition	inhibition	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cytokine-induced	cytokine-induced	JJ	JJ	_	8	amod	_	_
8	E-selectin	e-selectin	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	VCAM-1	vcam-1	NN	NN	_	8	conj	_	_
11	expression	expression	NN	NN	_	8	dep	_	_
12	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NAC	nac	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	a	a	DT	DT	_	16	det	_	_
13	well-characterized	well-characterized	JJ	JJ	_	16	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	thiol-containing	thiol-containing	JJ	JJ	_	13	dep	_	_
16	antioxidant	antioxidant	NN	NN	_	7	appos	_	_
17	,	,	,	,	_	5	punct	_	_
18	on	on	IN	IN	_	22	case	_	_
19	agonist-induced	agonist-induced	JJ	JJ	_	22	amod	_	_
20	monocytic	monocytic	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	adhesion	adhesion	NN	NN	_	5	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	EC	ec	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	3	punct	_	_

1	NAC	nac	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	interleukin-1	interleukin-1	NN	NN	_	8	dep	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	IL-1	il-1	NN	NN	_	6	compound	_	_
6	beta	beta	NN	NN	_	8	dep	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	-induced	-induced	JJ	JJ	_	14	amod	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	8	cc	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	basal	basal	JJ	JJ	_	8	conj	_	_
13	,	,	,	,	_	14	punct	_	_
14	adhesion	adhesion	NN	NN	_	2	dobj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	50	50	CD	CD	_	17	compound	_	_
17	%	%	NN	NN	_	18	amod	_	_
18	inhibition	inhibition	NN	NN	_	2	nmod	_	_
19	at	at	IN	IN	_	22	case	_	_
20	approximately	approximately	RB	RB	_	21	advmod	_	_
21	20	20	CD	CD	_	22	nummod	_	_
22	mM	mm	NN	NN	_	2	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Monocytic	monocytic	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	adhesion	adhesion	NN	NN	_	32	nsubjpass	_	_
4	to	to	TO	TO	_	5	case	_	_
5	EC	ec	NNS	NNS	_	3	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	3	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor-alpha	factor-alpha	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	lipopolysaccharide	lipopolysaccharide	NN	NN	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	LPS	lps	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	11	punct	_	_
21	alpha-thrombin	alpha-thrombin	NN	NN	_	11	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	or	or	CC	CC	_	11	cc	_	_
24	phorbol	phorbol	NN	NN	_	26	compound	_	_
25	12-myristate	12-myristate	NN	NN	_	26	compound	_	_
26	13-acetate	13-acetate	NN	NN	_	11	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PMA	pma	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	was	be	VBD	VBD	_	32	auxpass	_	_
31	similarly	similarly	RB	RB	_	32	advmod	_	_
32	inhibited	inhibit	VBN	VBN	_	0	root	_	_
33	by	by	IN	IN	_	34	case	_	_
34	NAC	nac	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	32	punct	_	_

1	Unlike	unlike	IN	IN	_	3	case	_	_
2	published	publish	VBN	VBN	_	3	amod	_	_
3	studies	study	NNS	NNS	_	20	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	inhibited	inhibit	VBD	VBD	_	5	acl:relcl	_	_
10	vascular	vascular	JJ	JJ	_	13	amod	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	adhesion	adhesion	NN	NN	_	13	compound	_	_
13	molecule	molecule	NN	NN	_	9	dobj	_	_
14	1	1	CD	CD	_	13	nummod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	VCAM-1	vcam-1	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	20	punct	_	_
19	NAC	nac	NN	NN	_	20	nsubj	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	IL-1	il-1	NN	NN	_	23	compound	_	_
22	beta-induced	beta-induced	JJ	JJ	_	23	amod	_	_
23	mRNA	mrna	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	surface	surface	NN	NN	_	23	conj	_	_
27	expression	expression	NN	NN	_	23	dep	_	_
28	of	of	IN	IN	_	30	case	_	_
29	both	both	CC	CC	_	30	cc:preconj	_	_
30	E-selectin	e-selectin	NN	NN	_	23	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	VCAM-1	vcam-1	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	20	punct	_	_

1	NAC	nac	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	no	no	DT	DT	_	4	neg	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	half-life	half-life	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	E-selectin	e-selectin	NN	NN	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	VCAM-1	vcam-1	NN	NN	_	9	conj	_	_
12	mRNA	mrna	NN	NN	_	9	dep	_	_
13	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	NAC	nac	NN	NN	_	3	nsubj	_	_
3	reduced	reduce	VBD	VBD	_	42	advcl	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	activation	activation	NN	NN	_	3	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	EC	ec	NNS	NNS	_	11	nmod	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	measured	measure	VBN	VBN	_	3	advcl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	gel-shift	gel-shift	JJ	JJ	_	18	amod	_	_
18	assays	assay	NNS	NNS	_	15	nmod	_	_
19	using	use	VBG	VBG	_	18	acl	_	_
20	an	a	DT	DT	_	22	det	_	_
21	oligonucleotide	oligonucleotide	NN	NN	_	22	compound	_	_
22	probe	probe	NN	NN	_	19	dobj	_	_
23	corresponding	correspond	VBG	VBG	_	22	acl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	consensus	consensus	NN	NN	_	23	nmod	_	_
27	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	sites	site	NNS	NNS	_	26	dep	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	VCAM-1	vcam-1	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	26	nmod	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	VCAM-NF-kappa	vcam-nf-kappa	NN	NN	_	37	compound	_	_
37	B	b	NN	NN	_	26	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	,	,	,	,	_	42	punct	_	_
40	the	the	DT	DT	_	41	det	_	_
41	antioxidant	antioxidant	NN	NN	_	42	nsubj	_	_
42	had	have	VBD	VBD	_	0	root	_	_
43	no	no	DT	DT	_	45	neg	_	_
44	appreciable	appreciable	JJ	JJ	_	45	amod	_	_
45	effect	effect	NN	NN	_	42	dobj	_	_
46	when	when	WRB	WRB	_	66	advmod	_	_
47	an	a	DT	DT	_	48	det	_	_
48	oligomer	oligomer	NN	NN	_	66	nsubjpass	_	_
49	corresponding	correspond	VBG	VBG	_	48	acl	_	_
50	to	to	TO	TO	_	56	case	_	_
51	the	the	DT	DT	_	56	det	_	_
52	consensus	consensus	NN	NN	_	56	compound	_	_
53	NF-kappa	nf-kappa	NN	NN	_	56	compound	_	_
54	B	b	NN	NN	_	56	compound	_	_
55	binding	binding	NN	NN	_	56	compound	_	_
56	site	site	NN	NN	_	49	nmod	_	_
57	of	of	IN	IN	_	60	case	_	_
58	the	the	DT	DT	_	60	det	_	_
59	E-selectin	e-selectin	NN	NN	_	60	compound	_	_
60	gene	gene	NN	NN	_	56	nmod	_	_
61	(	(	-LRB-	-LRB-	_	63	punct	_	_
62	E-selectin-NF-kappa	e-selectin-nf-kappa	NN	NN	_	63	compound	_	_
63	B	b	NN	NN	_	56	appos	_	_
64	)	)	-RRB-	-RRB-	_	63	punct	_	_
65	was	be	VBD	VBD	_	66	auxpass	_	_
66	used	use	VBN	VBN	_	42	advcl	_	_
67	.	.	.	.	_	42	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	reported	report	VBN	VBN	_	13	advcl	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	redox	redox	NN	NN	_	10	nmod:npmod	_	_
10	sensitive	sensitive	JJ	JJ	_	6	xcomp	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	studied	study	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NAC	nac	NN	NN	_	15	nmod	_	_
18	on	on	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	EC	ec	NNS	NNS	_	22	compound	_	_
21	redox	redox	NN	NN	_	22	compound	_	_
22	environment	environment	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	NAC	nac	NN	NN	_	2	nsubj	_	_
2	caused	cause	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	6	det	_	_
4	expected	expect	VBN	VBN	_	6	amod	_	_
5	dramatic	dramatic	JJ	JJ	_	4	dep	_	_
6	increase	increase	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	reduced	reduce	VBN	VBN	_	14	amod	_	_
10	glutathione	glutathione	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	GSH	gsh	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	levels	level	NNS	NNS	_	6	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	EC	ec	NNS	NNS	_	2	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	43	mark	_	_
6	whereas	whereas	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	affinity	affinity	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	VCAM-NF-kappa	vcam-nf-kappa	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	oligomer	oligomer	NN	NN	_	9	nmod	_	_
18	peaked	peak	VBD	VBD	_	43	advcl	_	_
19	at	at	IN	IN	_	26	case	_	_
20	a	a	DT	DT	_	26	det	_	_
21	GSH-to-oxidized	gsh-to-oxidized	JJ	JJ	_	22	amod	_	_
22	glutathione	glutathione	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	GSSG	gssg	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	ratio	ratio	NN	NN	_	18	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	approximately	approximately	RB	RB	_	29	advmod	_	_
29	200	200	CD	CD	_	26	nmod	_	_
30	and	and	CC	CC	_	18	cc	_	_
31	decreased	decrease	VBD	VBD	_	18	conj	_	_
32	at	at	IN	IN	_	34	case	_	_
33	higher	higher	JJR	JJR	_	34	amod	_	_
34	ratios	ratio	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	43	punct	_	_
36	the	the	DT	DT	_	37	det	_	_
37	binding	binding	NN	NN	_	43	nsubj	_	_
38	to	to	TO	TO	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	E-selectin-NF-kappa	e-selectin-nf-kappa	NN	NN	_	42	compound	_	_
41	B	b	NN	NN	_	42	compound	_	_
42	oligomer	oligomer	NN	NN	_	37	nmod	_	_
43	appeared	appear	VBD	VBD	_	4	ccomp	_	_
44	relatively	relatively	RB	RB	_	45	advmod	_	_
45	unaffected	unaffected	JJ	JJ	_	43	xcomp	_	_
46	even	even	RB	RB	_	48	advmod	_	_
47	at	at	IN	IN	_	48	case	_	_
48	ratios	ratio	NNS	NNS	_	45	nmod	_	_
49	&gt;	&gt;	JJR	JJR	_	50	advmod	_	_
50	400	400	CD	CD	_	48	nummod	_	_
51	,	,	,	,	_	48	punct	_	_
52	i.e.	i.e.	FW	FW	_	48	acl	_	_
53	,	,	,	,	_	48	punct	_	_
54	those	those	DT	DT	_	48	appos	_	_
55	achieved	achieve	VBN	VBN	_	54	acl	_	_
56	in	in	IN	IN	_	57	case	_	_
57	EC	ec	NNS	NNS	_	55	nmod	_	_
58	treated	treat	VBN	VBN	_	57	acl	_	_
59	with	with	IN	IN	_	62	case	_	_
60	40	40	CD	CD	_	61	compound	_	_
61	mM	mm	NN	NN	_	62	amod	_	_
62	NAC	nac	NN	NN	_	58	nmod	_	_
63	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	18	nsubj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	consensus	consensus	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	VCAM-1	vcam-1	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	E-selectin	e-selectin	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	14	conj	_	_
18	exhibits	exhibit	VBZ	VBZ	_	3	ccomp	_	_
19	marked	marked	JJ	JJ	_	20	amod	_	_
20	differences	difference	NNS	NNS	_	18	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	redox	redox	NN	NN	_	23	compound	_	_
23	sensitivity	sensitivity	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	allowing	allow	VBG	VBG	_	18	advcl	_	_
26	for	for	IN	IN	_	29	case	_	_
27	differential	differential	JJ	JJ	_	29	amod	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	25	nmod	_	_
30	regulated	regulate	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	same	same	JJ	JJ	_	35	amod	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	factor	factor	NN	NN	_	30	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	NAC	nac	NN	NN	_	7	nsubj	_	_
7	increases	increase	VBZ	VBZ	_	4	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GSH-to-GSSG	gsh-to-gssg	JJ	JJ	_	10	amod	_	_
10	ratio	ratio	NN	NN	_	7	dobj	_	_
11	within	within	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	EC	ec	NNS	NNS	_	10	nmod	_	_
14	suggesting	suggest	VBG	VBG	_	4	xcomp	_	_
15	one	one	CD	CD	_	17	nummod	_	_
16	possible	possible	JJ	JJ	_	17	amod	_	_
17	mechanism	mechanism	NN	NN	_	14	dobj	_	_
18	through	through	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	22	nmod	_	_
20	this	this	DT	DT	_	21	det	_	_
21	antioxidant	antioxidant	NN	NN	_	22	nsubj	_	_
22	inhibits	inhibit	VBZ	VBZ	_	17	acl:relcl	_	_
23	agonist-induced	agonist-induced	JJ	JJ	_	25	amod	_	_
24	monocyte	monocyte	NN	NN	_	25	compound	_	_
25	adhesion	adhesion	NN	NN	_	22	dobj	_	_
26	to	to	TO	TO	_	27	case	_	_
27	EC	ec	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	monocyte	monocyte	NN	NN	_	6	nsubj	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	5	case	_	_
5	fibronectin	fibronectin	NN	NN	_	3	nmod	_	_
6	enhances	enhance	VBZ	VBZ	_	0	root	_	_
7	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	10	amod	_	_
8	early	early	JJ	JJ	_	10	amod	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	events	event	NNS	NNS	_	6	dobj	_	_
11	.	.	.	.	_	6	punct	_	_

1	Leukocyte	leukocyte	NN	NN	_	2	compound	_	_
2	integrins	integrin	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	fundamentally	fundamentally	RB	RB	_	5	advmod	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	modulating	modulate	VBG	VBG	_	5	advcl	_	_
8	adhesion	adhesion	NN	NN	_	7	dobj	_	_
9	to	to	TO	TO	_	12	case	_	_
10	extracellular	extracellular	JJ	JJ	_	12	amod	_	_
11	matrix	matrix	NN	NN	_	12	compound	_	_
12	components	component	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	to	to	TO	TO	_	16	case	_	_
15	other	other	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	integrin-mediated	integrin-mediated	JJ	JJ	_	3	amod	_	_
3	adhesion	adhesion	NN	NN	_	4	nsubj	_	_
4	controls	control	VBZ	VBZ	_	0	root	_	_
5	leukocyte	leukocyte	NN	NN	_	4	dobj	_	_
6	arrest	arrest	NN	NN	_	5	dep	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	extravasation	extravasation	NN	NN	_	5	conj	_	_
9	during	during	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	onset	onset	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	integrin-ligand	integrin-ligand	JJ	JJ	_	4	amod	_	_
4	interactions	interaction	NNS	NNS	_	5	nsubj	_	_
5	trigger	trigger	VBP	VBP	_	0	root	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	pathways	pathway	NNS	NNS	_	5	dobj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	influence	influence	VB	VB	_	7	acl:relcl	_	_
11	leukocyte	leukocyte	NN	NN	_	12	compound	_	_
12	phenotype	phenotype	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	function	function	VB	VB	_	10	conj	_	_
15	at	at	IN	IN	_	16	case	_	_
16	sites	site	NNS	NNS	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	inflammation	inflammation	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	evaluated	evaluate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	combinatorial	combinatorial	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	monocyte	monocyte	NN	NN	_	13	compound	_	_
13	adhesion	adhesion	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	conj	_	_
16	on	on	IN	IN	_	19	case	_	_
17	intracellular	intracellular	JJ	JJ	_	19	amod	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	pathways	pathway	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	nsubj	_	_
2	triggers	trigger	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	7	det	_	_
4	well-defined	well-defined	JJ	JJ	_	7	amod	_	_
5	signal	signal	NN	NN	_	7	compound	_	_
6	transduction	transduction	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	28	nsubjpass	_	_
10	although	although	IN	IN	_	13	mark	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	directly	directly	RB	RB	_	13	advmod	_	_
13	stimulated	stimulate	VBN	VBN	_	28	dep	_	_
14	by	by	IN	IN	_	16	case	_	_
15	monocyte	monocyte	NN	NN	_	16	compound	_	_
16	adherence	adherence	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	fibronectin	fibronectin	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	arginine-glycine-aspartate	arginine-glycine-aspartate	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	RGD	rgd	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	-coated	-coated	JJ	JJ	_	25	amod	_	_
25	substrata	substratum	NNS	NNS	_	18	conj	_	_
26	,	,	,	,	_	28	punct	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	enhanced	enhance	VBN	VBN	_	7	acl:relcl	_	_
29	significantly	significantly	RB	RB	_	28	advmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	these	these	DT	DT	_	33	det	_	_
32	matrix-adherent	matrix-adherent	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Compared	compare	VBN	VBN	_	3	case	_	_
2	with	with	IN	IN	_	3	case	_	_
3	monocytes	monocyte	NNS	NNS	_	18	advcl	_	_
4	in	in	IN	IN	_	5	case	_	_
5	suspension	suspension	NN	NN	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	adherent	adherent	JJ	JJ	_	5	conj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	plastic	plastic	JJ	JJ	_	10	amod	_	_
10	surfaces	surface	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	monocytes	monocyte	NNS	NNS	_	18	nsubj	_	_
13	adherent	adherent	JJ	JJ	_	12	amod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	fibronectin	fibronectin	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	RGD	rgd	NN	NN	_	15	conj	_	_
18	exhibited	exhibit	VBD	VBD	_	0	root	_	_
19	a	a	DT	DT	_	23	det	_	_
20	greater	greater	JJR	JJR	_	22	dep	_	_
21	than	than	IN	IN	_	22	dep	_	_
22	threefold	threefold	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	18	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	steady	steady	JJ	JJ	_	27	amod	_	_
26	state	state	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	30	amod	_	_
30	mRNA	mrna	NN	NN	_	27	nmod	_	_
31	for	for	IN	IN	_	37	case	_	_
32	the	the	DT	DT	_	37	det	_	_
33	high	high	JJ	JJ	_	37	amod	_	_
34	affinity	affinity	NN	NN	_	37	compound	_	_
35	Fc	fc	NN	NN	_	37	compound	_	_
36	gammaRI	gammari	NN	NN	_	37	compound	_	_
37	receptor	receptor	NN	NN	_	30	nmod	_	_
38	.	.	.	.	_	18	punct	_	_

1	By	by	IN	IN	_	5	case	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	12	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	this	this	DT	DT	_	8	det	_	_
8	increase	increase	NN	NN	_	12	nsubjpass	_	_
9	in	in	IN	IN	_	10	case	_	_
10	mRNA	mrna	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	5-	5-	CD	CD	_	17	compound	_	_
16	to	to	TO	TO	_	17	dep	_	_
17	10-fold	10-fold	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	STAT1-containing	stat1-containing	JJ	JJ	_	23	amod	_	_
22	DNA-binding	dna-binding	JJ	JJ	_	23	amod	_	_
23	complex	complex	NN	NN	_	18	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	binds	bind	VBZ	VBZ	_	23	acl:relcl	_	_
26	to	to	TO	TO	_	30	case	_	_
27	Fc	fc	NN	NN	_	30	compound	_	_
28	gammaRI	gammari	NN	NN	_	30	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	elements	element	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	STAT1	stat1	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	kinases	kinase	NNS	NNS	_	7	conj	_	_
12	JAK1	jak1	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	JAK2	jak2	NN	NN	_	12	conj	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	enhanced	enhance	VBN	VBN	_	0	root	_	_
17	significantly	significantly	RB	RB	_	16	advmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	RGD-adherent	rgd-adherent	JJ	JJ	_	20	amod	_	_
20	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
21	compared	compare	VBN	VBN	_	24	case	_	_
22	with	with	IN	IN	_	24	case	_	_
23	control	control	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	16	advcl	_	_
25	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	13	nmod	_	_
9	integrin-mediated	integrin-mediated	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	adhesion	adhesion	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	modulate	modulate	VB	VB	_	6	acl:relcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	magnitude	magnitude	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	cytokine-induced	cytokine-induced	JJ	JJ	_	20	amod	_	_
18	signal	signal	NN	NN	_	20	compound	_	_
19	transduction	transduction	NN	NN	_	20	compound	_	_
20	pathways	pathway	NNS	NNS	_	15	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	thereby	thereby	RB	RB	_	23	advmod	_	_
23	amplifying	amplify	VBG	VBG	_	13	advcl	_	_
24	cellular	cellular	JJ	JJ	_	25	amod	_	_
25	events	event	NNS	NNS	_	23	dobj	_	_
26	leading	lead	VBG	VBG	_	25	acl	_	_
27	to	to	TO	TO	_	28	case	_	_
28	monocyte	monocyte	NN	NN	_	26	nmod	_	_
29	activation	activation	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	inflammation	inflammation	NN	NN	_	28	conj	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	4	amod	_	_
3	cytoplasmic	cytoplasmic	JJ	JJ	_	4	amod	_	_
4	domain	domain	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD36	cd36	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	13	case	_	_
10	oxidized	oxidize	VBN	VBN	_	13	amod	_	_
11	low-density	low-density	JJ	JJ	_	13	amod	_	_
12	lipoprotein	lipoprotein	NN	NN	_	13	compound	_	_
13	modulation	modulation	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	by	by	IN	IN	_	20	case	_	_
18	tumor	tumor	NN	NN	_	20	compound	_	_
19	necrosis	necrosis	NN	NN	_	20	compound	_	_
20	factor-alpha	factor-alpha	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	oxidized	oxidize	VBN	VBN	_	6	amod	_	_
5	low-density	low-density	JJ	JJ	_	6	amod	_	_
6	lipoprotein	lipoprotein	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	Ox	ox	NN	NN	_	9	compound	_	_
9	LDL	ldl	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	by	by	IN	IN	_	12	case	_	_
12	monocyte-macrophages	monocyte-macrophage	NNS	NNS	_	2	nmod	_	_
13	causes	cause	VBZ	VBZ	_	0	root	_	_
14	pleiotropic	pleiotropic	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	13	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	including	include	VBG	VBG	_	18	case	_	_
18	changes	change	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	thought	think	VBN	VBN	_	13	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	represent	represent	VB	VB	_	25	xcomp	_	_
28	an	a	DT	DT	_	30	det	_	_
29	early	early	JJ	JJ	_	30	amod	_	_
30	event	event	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	atherogenesis	atherogenesis	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	integral	integral	JJ	JJ	_	3	amod	_	_
3	membrane	membrane	NN	NN	_	6	nsubj	_	_
4	glycoprotein	glycoprotein	NN	NN	_	5	compound	_	_
5	CD36	cd36	NN	NN	_	3	dep	_	_
6	appears	appear	VBZ	VBZ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	play	play	VB	VB	_	6	xcomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	physiological	physiological	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	binding	binding	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	uptake	uptake	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Ox	ox	NN	NN	_	18	compound	_	_
18	LDL	ldl	NN	NN	_	13	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	monocyte-macrophages	monocyte-macrophage	NNS	NNS	_	13	nmod	_	_
21	,	,	,	,	_	6	punct	_	_
22	although	although	IN	IN	_	32	mark	_	_
23	the	the	DT	DT	_	25	det	_	_
24	molecular	molecular	JJ	JJ	_	25	amod	_	_
25	events	event	NNS	NNS	_	32	nsubj	_	_
26	associated	associate	VBN	VBN	_	25	acl	_	_
27	with	with	IN	IN	_	30	case	_	_
28	CD36-Ox	cd36-ox	NN	NN	_	30	compound	_	_
29	LDL	ldl	NN	NN	_	30	compound	_	_
30	interaction	interaction	NN	NN	_	26	nmod	_	_
31	are	be	VBP	VBP	_	32	cop	_	_
32	unknown	unknown	JJ	JJ	_	6	advcl	_	_
33	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	approach	approach	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	issue	issue	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	used	use	VBD	VBD	_	2	parataxis	_	_
8	CD36	cd36	NN	NN	_	7	dobj	_	_
9	transfected	transfected	JJ	JJ	_	8	amod	_	_
10	Chinese	chinese	JJ	JJ	_	16	amod	_	_
11	hampster	hampster	NN	NN	_	16	compound	_	_
12	ovary	ovary	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	CHO	cho	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	cells	cell	NNS	NNS	_	8	dep	_	_
17	,	,	,	,	_	7	punct	_	_
18	exposed	expose	VBD	VBD	_	7	conj	_	_
19	them	they	PRP	PRP	_	18	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	Ox	ox	NN	NN	_	22	compound	_	_
22	LDL	ldl	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	and	and	CC	CC	_	7	cc	_	_
25	determined	determine	VBD	VBD	_	7	conj	_	_
26	changes	change	NNS	NNS	_	25	dobj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	activity	activity	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factor	factor	NN	NN	_	29	nmod	_	_
34	NF-kappaB	nf-kappab	NN	NN	_	33	dep	_	_
35	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Ox	ox	NN	NN	_	6	compound	_	_
6	LDL	ldl	NN	NN	_	7	nsubj	_	_
7	enhanced	enhance	VBD	VBD	_	2	ccomp	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	10	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	sequence	sequence	NN	NN	_	10	nmod	_	_
18	following	follow	VBG	VBG	_	19	case	_	_
19	activation	activation	NN	NN	_	7	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	CD36-producing	cd36-producing	JJ	JJ	_	23	amod	_	_
22	CHO	cho	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	with	with	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	proinflammatory	proinflammatory	JJ	JJ	_	27	amod	_	_
27	cytokine	cytokine	NN	NN	_	19	nmod	_	_
28	tumor	tumor	NN	NN	_	30	compound	_	_
29	necrosis	necrosis	NN	NN	_	30	compound	_	_
30	factor-alpha	factor-alpha	NN	NN	_	27	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	TNF-alpha	tnf-alpha	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	enhanced	enhance	VBN	VBN	_	5	amod	_	_
3	DNA	dna	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	coincubation	coincubation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	CD36	cd36	NN	NN	_	13	compound	_	_
12	transfected	transfect	VBN	VBN	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	CD36-specific	cd36-specific	JJ	JJ	_	18	amod	_	_
18	antibody	antibody	NN	NN	_	9	nmod	_	_
19	OKM5	okm5	NN	NN	_	18	dep	_	_
20	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	determined	determine	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	activation	activation	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	5	nmod	_	_
11	required	require	VBD	VBD	_	3	ccomp	_	_
12	an	a	DT	DT	_	16	det	_	_
13	intact	intact	JJ	JJ	_	16	amod	_	_
14	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	16	amod	_	_
15	cytoplasmic	cytoplasmic	JJ	JJ	_	16	amod	_	_
16	segment	segment	NN	NN	_	11	dobj	_	_
17	on	on	IN	IN	_	18	case	_	_
18	CD36	cd36	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	idea	idea	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	CD36	cd36	NN	NN	_	9	nsubj	_	_
9	mediates	mediate	VBZ	VBZ	_	5	ccomp	_	_
10	signal	signal	NN	NN	_	12	compound	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	events	event	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	response	response	NN	NN	_	9	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	Ox	ox	NN	NN	_	17	compound	_	_
17	LDL	ldl	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Sp3	sp3	NN	NN	_	2	nsubj	_	_
2	mediates	mediate	VBZ	VBZ	_	0	root	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	leukocyte	leukocyte	NN	NN	_	9	compound	_	_
8	integrin	integrin	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	4	nmod	_	_
10	CD11C	cd11c	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CD11B	cd11b	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	cooperates	cooperate	VBZ	VBZ	_	2	conj	_	_
15	with	with	IN	IN	_	16	case	_	_
16	c-Jun	c-jun	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	activate	activate	VB	VB	_	14	xcomp	_	_
19	CD11C	cd11c	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	leukocyte	leukocyte	NN	NN	_	4	compound	_	_
3	integrin	integrin	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	9	nsubjpass	_	_
5	CD11c	cd11c	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CD11b	cd11b	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	predominately	predominately	RB	RB	_	13	advmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	myelomonocytic	myelomonocytic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	29	nmod	_	_
4	,	,	,	,	_	29	punct	_	_
5	the	the	DT	DT	_	8	dep	_	_
6	-70	-70	CD	CD	_	8	compound	_	_
7	to	to	TO	TO	_	8	dep	_	_
8	-65	-65	CD	CD	_	29	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	-121	-121	CD	CD	_	12	compound	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	-103	-103	CD	CD	_	8	conj	_	_
13	regions	region	NNS	NNS	_	8	dep	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CD11c	cd11c	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	the	the	DT	DT	_	23	det	_	_
20	-66	-66	CD	CD	_	23	nummod	_	_
21	to	to	TO	TO	_	23	dep	_	_
22	-59	-59	CD	CD	_	23	nummod	_	_
23	region	region	NN	NN	_	8	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	CD11b	cd11b	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	23	nmod	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	shown	show	VBN	VBN	_	0	root	_	_
30	to	to	TO	TO	_	32	mark	_	_
31	be	be	VB	VB	_	32	cop	_	_
32	essential	essential	JJ	JJ	_	29	xcomp	_	_
33	for	for	IN	IN	_	35	case	_	_
34	Sp1-mediated	sp1-mediated	JJ	JJ	_	35	amod	_	_
35	activation	activation	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	these	these	DT	DT	_	38	det	_	_
38	genes	gene	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	29	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	genomic	genomic	JJ	JJ	_	1	dep	_	_
4	footprinting	footprinting	NN	NN	_	7	nsubj	_	_
5	had	have	VBD	VBD	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	revealed	reveal	VBN	VBN	_	0	root	_	_
8	cell-specific	cell-specific	JJ	JJ	_	9	amod	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	protein	protein	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	presumably	presumably	RB	RB	_	14	advmod	_	_
14	Sp1	sp1	NN	NN	_	11	appos	_	_
15	,	,	,	,	_	9	punct	_	_
16	to	to	TO	TO	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	regions	region	NNS	NNS	_	9	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
6	mobility	mobility	NN	NN	_	8	compound	_	_
7	shift	shift	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	9	nsubj	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Sp1-related	sp1-related	JJ	JJ	_	13	amod	_	_
13	factor	factor	NN	NN	_	18	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	Sp3	sp3	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	binds	bind	VBZ	VBZ	_	9	ccomp	_	_
19	at	at	IN	IN	_	24	nmod	_	_
20	or	or	CC	CC	_	24	cc	_	_
21	near	near	IN	IN	_	24	conj	_	_
22	these	these	DT	DT	_	24	det	_	_
23	same	same	JJ	JJ	_	24	amod	_	_
24	regions	region	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Sp3	sp3	NN	NN	_	1	nmod	_	_
4	along	along	IN	IN	_	8	case	_	_
5	with	with	IN	IN	_	8	case	_	_
6	CD11c	cd11c	NN	NN	_	8	compound	_	_
7	promoter-luciferase	promoter-luciferase	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	1	nmod	_	_
9	into	into	IN	IN	_	14	case	_	_
10	Sp-deficient	sp-deficient	JJ	JJ	_	14	amod	_	_
11	Drosophila	drosophila	NN	NN	_	14	compound	_	_
12	Schneider	schneider	NN	NN	_	14	compound	_	_
13	2	2	CD	CD	_	14	nummod	_	_
14	cells	cell	NNS	NNS	_	1	nmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	Sp3	sp3	NN	NN	_	19	nsubj	_	_
18	could	could	MD	MD	_	19	aux	_	_
19	activate	activate	VB	VB	_	15	ccomp	_	_
20	the	the	DT	DT	_	22	det	_	_
21	CD11c	cd11c	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	15	punct	_	_

1	Deletion	deletion	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	both	both	CC	CC	_	7	cc:preconj	_	_
4	the	the	DT	DT	_	7	dep	_	_
5	-70	-70	CD	CD	_	7	compound	_	_
6	to	to	TO	TO	_	7	dep	_	_
7	-65	-65	CD	CD	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	-121	-121	CD	CD	_	11	compound	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	-103	-103	CD	CD	_	7	conj	_	_
12	regions	region	NNS	NNS	_	7	dep	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CD11c	cd11c	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	7	nmod	_	_
17	resulted	result	VBD	VBD	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	loss	loss	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	20	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	Sp3	sp3	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	sites	site	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	activation	activation	NN	NN	_	3	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	Sp3	sp3	NN	NN	_	4	nmod	_	_
7	;	;	:	:	_	3	punct	_	_
8	however	however	RB	RB	_	17	advmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	the	the	DT	DT	_	14	det	_	_
11	-70	-70	CD	CD	_	14	nummod	_	_
12	to	to	TO	TO	_	14	dep	_	_
13	-65	-65	CD	CD	_	14	nummod	_	_
14	region	region	NN	NN	_	17	nsubj	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	more	more	JJR	JJR	_	17	dep	_	_
17	responsive	responsive	JJ	JJ	_	3	parataxis	_	_
18	to	to	TO	TO	_	19	case	_	_
19	Sp3	sp3	NN	NN	_	17	nmod	_	_
20	than	than	IN	IN	_	22	case	_	_
21	to	to	TO	TO	_	22	case	_	_
22	Sp1	sp1	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Similar	similar	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	-66	-66	CD	CD	_	9	nummod	_	_
7	to	to	TO	TO	_	9	dep	_	_
8	-59	-59	CD	CD	_	9	nummod	_	_
9	region	region	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD11b	cd11b	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	Sp3-dependent	sp3-dependent	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	14	punct	_	_

1	Further	further	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	cotransfection	cotransfection	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Drosophila	drosophila	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	20	mark	_	_
10	Sp3	sp3	NN	NN	_	20	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	as	as	IN	IN	_	15	mark	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	previously	previously	RB	RB	_	15	advmod	_	_
15	shown	show	VBN	VBN	_	20	dep	_	_
16	for	for	IN	IN	_	17	case	_	_
17	Sp1	sp1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	synergizes	synergize	VBZ	VBZ	_	8	ccomp	_	_
21	with	with	IN	IN	_	22	case	_	_
22	c-Jun	c-jun	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	activate	activate	VB	VB	_	20	xcomp	_	_
25	CD11c	cd11c	NN	NN	_	24	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Antisense	antisense	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	17	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	knocked	knock	VBD	VBD	_	2	acl:relcl	_	_
5	out	out	RP	RP	_	4	compound:prt	_	_
6	endogenous	endogenous	JJ	JJ	_	8	amod	_	_
7	Sp3	sp3	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	myelomocytic	myelomocytic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	HL60	hl60	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	2	punct	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	Sp3	sp3	NN	NN	_	20	nsubj	_	_
20	participates	participate	VBZ	VBZ	_	17	ccomp	_	_
21	in	in	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	CD11c	cd11c	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	CD11b	cd11b	NN	NN	_	25	conj	_	_
28	promoters	promoter	NNS	NNS	_	25	dep	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vivo	vivo	FW	FW	_	20	advmod	_	_
31	.	.	.	.	_	17	punct	_	_

1	STAT3	stat3	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	serine	serine	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	target	target	NN	NN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Interleukin	interleukin	NN	NN	_	9	nsubj	_	_
2	2	2	CD	CD	_	1	nummod	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	T	t	NN	NN	_	7	compound	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	antigen	antigen	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	1	conj	_	_
8	signals	signal	NNS	NNS	_	1	dep	_	_
9	converge	converge	VBP	VBP	_	0	root	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	serine	serine	NN	NN	_	9	nmod	_	_
12	727	727	CD	CD	_	11	nummod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Interleukin	interleukin	NN	NN	_	6	nsubj	_	_
2	2	2	CD	CD	_	1	nummod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-2	il-2	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STATs	stats	NNS	NNS	_	8	nmod	_	_
11	3	3	CD	CD	_	10	dep	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	5	5	CD	CD	_	10	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	signal	signal	NN	NN	_	10	dep	_	_
16	transducer	transducer	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	activator	activator	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	transcription	transcription	NN	NN	_	15	nmod	_	_
21	)	)	-RRB-	-RRB-	_	15	punct	_	_
22	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	regulation	regulation	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	STAT3	stat3	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	complex	complex	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	3	ccomp	_	_
17	involving	involve	VBG	VBG	_	16	acl	_	_
18	activation	activation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	two	two	CD	CD	_	21	nummod	_	_
21	forms	form	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	STAT3	stat3	NN	NN	_	21	nmod	_	_
24	:	:	:	:	_	3	punct	_	_
25	90-kDa	90-kda	JJ	JJ	_	26	amod	_	_
26	STAT3alpha	stat3alpha	NN	NN	_	3	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	an	a	DT	DT	_	32	det	_	_
29	83-kDa	83-kda	JJ	JJ	_	32	amod	_	_
30	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	32	amod	_	_
31	truncated	truncate	VBN	VBN	_	32	amod	_	_
32	STAT3beta	stat3beta	NN	NN	_	26	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	phosphorylation	phosphorylation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	STAT	stat	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	serine	serine	NN	NN	_	8	compound	_	_
8	residues	residue	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	competent	competent	JJ	JJ	_	15	amod	_	_
14	STAT	stat	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	critical	critical	JJ	JJ	_	5	amod	_	_
3	serine	serine	NN	NN	_	5	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	10	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	STAT3alpha	stat3alpha	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	at	at	IN	IN	_	10	case	_	_
10	position	position	NN	NN	_	0	root	_	_
11	727	727	CD	CD	_	10	nummod	_	_
12	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	produced	produce	VBN	VBN	_	0	root	_	_
7	an	a	DT	DT	_	8	det	_	_
8	antisera	antisera	NN	NN	_	6	dobj	_	_
9	specific	specific	JJ	JJ	_	8	amod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	STAT3alpha	stat3alpha	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	9	nmod	_	_
13	phosphorylated	phosphorylate	VBN	VBN	_	12	acl	_	_
14	on	on	IN	IN	_	15	case	_	_
15	serine	serine	NN	NN	_	13	nmod	_	_
16	727	727	CD	CD	_	15	nummod	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	used	use	VBN	VBN	_	6	conj	_	_
19	this	this	DT	DT	_	18	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	monitor	monitor	VB	VB	_	18	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	phosphorylation	phosphorylation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	residue	residue	NN	NN	_	23	nmod	_	_
27	during	during	IN	IN	_	30	case	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	lymphocyte	lymphocyte	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	21	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	phosphorylation	phosphorylation	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	STAT3alpha	stat3alpha	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	serine	serine	NN	NN	_	5	nmod	_	_
10	727	727	CD	CD	_	9	nummod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	constitutive	constitutive	JJ	JJ	_	3	ccomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	quiescent	quiescent	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	can	can	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	13	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cytokine	cytokine	NN	NN	_	25	compound	_	_
25	IL-2	il-2	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	triggering	triggering	NN	NN	_	21	nsubj	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	T	t	NN	NN	_	10	compound	_	_
7	cell	cell	NN	NN	_	10	compound	_	_
8	antigen	antigen	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	3	nmod	_	_
11	or	or	CC	CC	_	3	cc	_	_
12	activation	activation	NN	NN	_	3	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	protein	protein	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	C	c	NN	NN	_	12	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	esters	ester	NNS	NNS	_	12	nmod	_	_
20	also	also	RB	RB	_	21	advmod	_	_
21	induces	induce	VBZ	VBZ	_	0	root	_	_
22	phosphorylation	phosphorylation	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	serine	serine	NN	NN	_	22	nmod	_	_
25	727	727	CD	CD	_	24	nummod	_	_
26	but	but	CC	CC	_	21	cc	_	_
27	without	without	IN	IN	_	28	case	_	_
28	simultaneously	simultaneously	RB	RB	_	21	conj	_	_
29	inducing	induce	VBG	VBG	_	28	dep	_	_
30	STAT3	stat3	NN	NN	_	29	dobj	_	_
31	tyrosine	tyrosine	NN	NN	_	32	compound	_	_
32	phosphorylation	phosphorylation	NN	NN	_	30	dep	_	_
33	or	or	CC	CC	_	30	cc	_	_
34	DNA	dna	NN	NN	_	35	compound	_	_
35	binding	binding	NN	NN	_	30	conj	_	_
36	.	.	.	.	_	21	punct	_	_

1	Hence	hence	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	present	present	JJ	JJ	_	5	amod	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	STAT3	stat3	NN	NN	_	10	compound	_	_
9	serine	serine	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	13	nsubjpass	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	regulated	regulate	VBN	VBN	_	6	ccomp	_	_
14	independently	independently	RB	RB	_	13	advmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	molecule	molecule	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	IL-2	il-2	NN	NN	_	15	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	T	t	NN	NN	_	7	compound	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	antigen	antigen	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	1	conj	_	_
8	induction	induction	NN	NN	_	1	dep	_	_
9	of	of	IN	IN	_	13	case	_	_
10	STAT3alpha	stat3alpha	NN	NN	_	13	compound	_	_
11	serine	serine	NN	NN	_	13	compound	_	_
12	727	727	CD	CD	_	13	nummod	_	_
13	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	dependent	dependent	JJ	JJ	_	0	root	_	_
16	on	on	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	MEK/ERK	mek/erk	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	H-7-sensitive	h-7-sensitive	JJ	JJ	_	7	amod	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	pathways	pathway	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	regulate	regulate	VBP	VBP	_	7	acl:relcl	_	_
10	STAT3	stat3	NN	NN	_	12	compound	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	H-7-sensitive	h-7-sensitive	JJ	JJ	_	5	amod	_	_
5	pathways	pathway	NNS	NNS	_	6	nsubj	_	_
6	regulate	regulate	VBP	VBP	_	2	ccomp	_	_
7	STAT3	stat3	NN	NN	_	9	compound	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	H-7-sensitive	h-7-sensitive	JJ	JJ	_	7	amod	_	_
7	kinases	kinase	NNS	NNS	_	10	nsubj	_	_
8	do	do	VBP	VBP	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	regulate	regulate	VB	VB	_	4	ccomp	_	_
11	STAT3	stat3	NN	NN	_	13	compound	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	phosphorylation	phosphorylation	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	serine	serine	NN	NN	_	15	nmod	_	_
18	727	727	CD	CD	_	17	nummod	_	_
19	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	STAT3	stat3	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	targets	target	NNS	NNS	_	4	ccomp	_	_
10	for	for	IN	IN	_	13	case	_	_
11	multiple	multiple	JJ	JJ	_	13	amod	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	integrate	integrate	VB	VB	_	9	conj	_	_
20	signals	signal	NNS	NNS	_	19	dobj	_	_
21	from	from	IN	IN	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	cytokine	cytokine	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	antigen	antigen	NN	NN	_	27	compound	_	_
27	receptors	receptor	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Four	four	CD	CD	_	3	nummod	_	_
2	P-like	p-like	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	optimal	optimal	JJ	JJ	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	mouse	mouse	NN	NN	_	13	compound	_	_
12	IL-4	il-4	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	:	:	:	:	_	5	punct	_	_
15	involvement	involvement	NN	NN	_	5	dep	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	distinct	distinct	JJ	JJ	_	19	amod	_	_
19	set	set	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
22	factor	factor	NN	NN	_	26	compound	_	_
23	of	of	IN	IN	_	26	amod	_	_
24	activated	activate	VBN	VBN	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	activator	activator	NN	NN	_	31	compound	_	_
29	protein-1	protein-1	NN	NN	_	31	compound	_	_
30	family	family	NN	NN	_	31	compound	_	_
31	proteins	protein	NNS	NNS	_	19	conj	_	_
32	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	P	p	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	3	dobj	_	_
7	as	as	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	critical	critical	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	element	element	NN	NN	_	3	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	IL-4	il-4	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	mouse	mouse	NN	NN	_	5	compound	_	_
4	IL-4	il-4	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	8	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	are	be	VBP	VBP	_	0	root	_	_
9	five	five	CD	CD	_	10	nummod	_	_
10	elements	element	NNS	NNS	_	8	nsubj	_	_
11	homologous	homologous	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	P	p	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	11	nmod	_	_
17	designated	designate	VBN	VBN	_	10	acl	_	_
18	conserved	conserved	JJ	JJ	_	20	amod	_	_
19	lymphokine	lymphokine	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	17	xcomp	_	_
21	0	0	CD	CD	_	20	nummod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CLE0	cle0	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	20	punct	_	_
26	P	p	NN	NN	_	20	conj	_	_
27	,	,	,	,	_	20	punct	_	_
28	P2	p2	NN	NN	_	20	conj	_	_
29	,	,	,	,	_	20	punct	_	_
30	P3	p3	NN	NN	_	20	conj	_	_
31	and	and	CC	CC	_	20	cc	_	_
32	P4	p4	NN	NN	_	20	conj	_	_
33	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	P-like	p-like	JJ	JJ	_	8	amod	_	_
8	elements	element	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	native	native	JJ	JJ	_	16	amod	_	_
16	promoter	promoter	NN	NN	_	4	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	did	do	VBD	VBD	_	2	parataxis	_	_
20	transient	transient	JJ	JJ	_	21	amod	_	_
21	transfection	transfection	NN	NN	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	electrophoretic	electrophoretic	JJ	JJ	_	26	amod	_	_
24	mobility	mobility	NN	NN	_	26	compound	_	_
25	shift	shift	NN	NN	_	26	compound	_	_
26	assays	assay	NNS	NNS	_	21	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	EMSA	emsa	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	2	punct	_	_

1	Transfection	transfection	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	EL-4	el-4	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	IL-4	il-4	NN	NN	_	9	compound	_	_
8	promoter-reporter	promoter-reporter	NN	NN	_	9	compound	_	_
9	constructs	construct	NNS	NNS	_	1	nmod	_	_
10	carrying	carry	VBG	VBG	_	9	acl	_	_
11	mutated	mutate	VBN	VBN	_	13	amod	_	_
12	P-like	p-like	JJ	JJ	_	13	amod	_	_
13	elements	element	NNS	NNS	_	10	dobj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	33	mark	_	_
16	four	four	CD	CD	_	18	nummod	_	_
17	P-like	p-like	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	33	nsubjpass	_	_
19	,	,	,	,	_	18	punct	_	_
20	CLE0	cle0	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	20	punct	_	_
22	P	p	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	P2	p2	NN	NN	_	20	conj	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	P4	p4	NN	NN	_	20	conj	_	_
27	,	,	,	,	_	18	punct	_	_
28	but	but	CC	CC	_	29	cc	_	_
29	not	not	RB	RB	_	18	cc	_	_
30	P3	p3	NN	NN	_	18	conj	_	_
31	,	,	,	,	_	18	punct	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	required	require	VBN	VBN	_	14	ccomp	_	_
34	for	for	IN	IN	_	36	case	_	_
35	optimal	optimal	JJ	JJ	_	36	amod	_	_
36	activation	activation	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	IL-4	il-4	NN	NN	_	40	compound	_	_
40	promoter	promoter	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	14	punct	_	_

1	EMSA	emsa	NN	NN	_	2	nsubj	_	_
2	showed	show	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	constitutive	constitutive	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	inducible	inducible	JJ	JJ	_	5	conj	_	_
8	complexes	complex	NNS	NNS	_	9	nsubj	_	_
9	bound	bind	VBD	VBD	_	2	ccomp	_	_
10	to	to	TO	TO	_	11	case	_	_
11	CLE0	cle0	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	P	p	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	P2	p2	NN	NN	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	P4	p4	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	9	punct	_	_
19	whereas	whereas	IN	IN	_	24	mark	_	_
20	only	only	RB	RB	_	23	advmod	_	_
21	a	a	DT	DT	_	23	det	_	_
22	constitutive	constitutive	JJ	JJ	_	23	amod	_	_
23	complex	complex	NN	NN	_	24	nsubj	_	_
24	bound	bind	VBD	VBD	_	9	advcl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	P3	p3	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	competition	competition	NN	NN	_	16	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	antibody	antibody	NN	NN	_	5	compound	_	_
5	supershift	supershift	NN	NN	_	2	conj	_	_
6	assays	assay	NNS	NNS	_	2	dep	_	_
7	in	in	IN	IN	_	8	case	_	_
8	EMSA	emsa	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	complexes	complex	NNS	NNS	_	16	nsubj	_	_
11	formed	form	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	P	p	NN	NN	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	P2	p2	NN	NN	_	13	conj	_	_
16	proved	prove	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	contain	contain	VB	VB	_	16	xcomp	_	_
19	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
20	factor	factor	NN	NN	_	29	compound	_	_
21	of	of	IN	IN	_	29	amod	_	_
22	activated	activate	VBN	VBN	_	29	amod	_	_
23	T	t	NN	NN	_	29	compound	_	_
24	cells	cell	NNS	NNS	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	NFAT	nfat	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	family	family	NN	NN	_	29	compound	_	_
29	proteins	protein	NNS	NNS	_	18	dobj	_	_
30	as	as	IN	IN	_	32	case	_	_
31	major	major	JJ	JJ	_	32	amod	_	_
32	components	component	NNS	NNS	_	18	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	Activator	activator	NN	NN	_	8	compound	_	_
2	protein	protein	NN	NN	_	8	compound	_	_
3	(	(	-LRB-	-LRB-	_	8	punct	_	_
4	AP	ap	NN	NN	_	8	compound	_	_
5	)	)	-RRB-	-RRB-	_	8	punct	_	_
6	-1	-1	CD	CD	_	8	nummod	_	_
7	family	family	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	9	nsubj	_	_
9	interacted	interact	VBD	VBD	_	0	root	_	_
10	with	with	IN	IN	_	11	case	_	_
11	CLE0	cle0	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	P	p	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	P2	p2	NN	NN	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	P4	p4	NN	NN	_	11	conj	_	_
18	.	.	.	.	_	9	punct	_	_

1	NFAT/AP-1	nfat/ap-1	NN	NN	_	2	compound	_	_
2	complex	complex	NN	NN	_	3	nsubj	_	_
3	formed	form	VBD	VBD	_	0	root	_	_
4	only	only	RB	RB	_	6	advmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	P	p	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	P2	p2	NN	NN	_	6	conj	_	_
9	.	.	.	.	_	3	punct	_	_

1	Cross-competition	cross-competition	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	7	nsubj	_	_
3	among	among	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	P-like	p-like	JJ	JJ	_	6	amod	_	_
6	elements	element	NNS	NNS	_	2	nmod	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	element-specific	element-specific	JJ	JJ	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	common	common	JJ	JJ	_	8	conj	_	_
11	complexes	complex	NNS	NNS	_	8	dep	_	_
12	.	.	.	.	_	7	punct	_	_

1	Six	six	CD	CD	_	3	nummod	_	_
2	tandem	tandem	JJ	JJ	_	3	amod	_	_
3	repeats	repeat	NNS	NNS	_	13	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	P	p	NN	NN	_	7	compound	_	_
7	element	element	NN	NN	_	3	nmod	_	_
8	linked	link	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	SV40	sv40	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	responded	respond	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	17	case	_	_
15	phorbol	phorbol	NN	NN	_	17	compound	_	_
16	12-myristate	12-myristate	NN	NN	_	17	compound	_	_
17	13-acetate	13-acetate	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	while	while	IN	IN	_	24	mark	_	_
20	that	that	DT	DT	_	24	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	other	other	JJ	JJ	_	23	amod	_	_
23	elements	element	NNS	NNS	_	20	nmod	_	_
24	did	do	VBD	VBD	_	13	advcl	_	_
25	not	not	RB	RB	_	24	neg	_	_
26	.	.	.	.	_	13	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	would	would	MD	MD	_	4	aux	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	appear	appear	VB	VB	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	components	component	NNS	NNS	_	14	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	each	each	DT	DT	_	11	det	_	_
9	P-like	p-like	JJ	JJ	_	11	amod	_	_
10	element-binding	element-binding	JJ	JJ	_	11	amod	_	_
11	complexes	complex	NNS	NNS	_	6	nmod	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	identical	identical	JJ	JJ	_	4	ccomp	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	coordinately	coordinately	RB	RB	_	18	advmod	_	_
18	contribute	contribute	VB	VB	_	14	conj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Negative	negative	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	HLA-DO	hla-do	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	10	case	_	_
6	MHC	mhc	NN	NN	_	10	compound	_	_
7	class	class	NN	NN	_	10	compound	_	_
8	II-restricted	ii-restricted	JJ	JJ	_	10	amod	_	_
9	antigen	antigen	NN	NN	_	10	compound	_	_
10	processing	processing	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	HLA-DM	hla-dm	NN	NN	_	12	nsubj	_	_
2	is	be	VBZ	VBZ	_	12	cop	_	_
3	a	a	DT	DT	_	12	det	_	_
4	major	major	JJ	JJ	_	12	amod	_	_
5	histocompatibility	histocompatibility	NN	NN	_	12	compound	_	_
6	complex	complex	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	12	punct	_	_
8	MHC	mhc	NN	NN	_	12	compound	_	_
9	)	)	-RRB-	-RRB-	_	12	punct	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II-like	ii-like	JJ	JJ	_	12	amod	_	_
12	molecule	molecule	NN	NN	_	0	root	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	facilitates	facilitate	VBZ	VBZ	_	12	acl:relcl	_	_
15	antigen	antigen	NN	NN	_	16	compound	_	_
16	processing	processing	NN	NN	_	14	dobj	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	catalyzing	catalyze	VBG	VBG	_	14	advcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	exchange	exchange	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	invariant	invariant	JJ	JJ	_	24	amod	_	_
23	chain-derived	chain-derived	JJ	JJ	_	24	amod	_	_
24	peptides	peptide	NNS	NNS	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CLIP	clip	NNS	NNS	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	from	from	IN	IN	_	31	case	_	_
29	class	class	NN	NN	_	31	compound	_	_
30	II	ii	CD	CD	_	31	nummod	_	_
31	molecules	molecule	NNS	NNS	_	24	nmod	_	_
32	for	for	IN	IN	_	34	case	_	_
33	antigenic	antigenic	JJ	JJ	_	34	amod	_	_
34	peptides	peptide	NNS	NNS	_	18	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	HLA-DO	hla-do	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	second	second	JJ	JJ	_	7	amod	_	_
5	class	class	NN	NN	_	7	compound	_	_
6	II-like	ii-like	JJ	JJ	_	7	amod	_	_
7	molecule	molecule	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	physically	physically	RB	RB	_	10	advmod	_	_
10	associates	associate	VBZ	VBZ	_	7	acl:relcl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	HLA-DM	hla-dm	NN	NN	_	10	nmod	_	_
13	in	in	NN	NN	_	15	dep	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	HLA-DO	hla-do	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	block	block	VB	VB	_	3	xcomp	_	_
6	HLA-DM	hla-dm	NN	NN	_	7	compound	_	_
7	function	function	NN	NN	_	5	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	Purified	purify	VBN	VBN	_	3	amod	_	_
2	HLA-DM-DO	hla-dm-do	NN	NN	_	3	compound	_	_
3	complexes	complex	NNS	NNS	_	6	nsubj	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	promote	promote	VB	VB	_	0	root	_	_
7	peptide	peptide	NN	NN	_	8	compound	_	_
8	exchange	exchange	NN	NN	_	6	dobj	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HLA-DO	hla-do	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	class	class	NN	NN	_	7	nmod:npmod	_	_
7	II+	ii+	JJ	JJ	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	DM+	dm+	JJ	JJ	_	15	amod	_	_
10	,	,	,	,	_	15	punct	_	_
11	DO-	do-	JJ	JJ	_	15	amod	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	7	conj	_	_
16	caused	cause	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	accumulation	accumulation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II-CLIP	ii-clip	NN	NN	_	22	compound	_	_
22	complexes	complex	NNS	NNS	_	18	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	indicating	indicate	VBG	VBG	_	16	dep	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	HLA-DO	hla-do	NN	NN	_	27	nsubj	_	_
27	blocked	block	VBD	VBD	_	24	ccomp	_	_
28	DM	dm	NN	NN	_	29	compound	_	_
29	function	function	NN	NN	_	27	dobj	_	_
30	in	in	FW	FW	_	31	compound	_	_
31	vivo	vivo	FW	FW	_	27	advmod	_	_
32	and	and	CC	CC	_	24	cc	_	_
33	suggesting	suggest	VBG	VBG	_	24	conj	_	_
34	that	that	IN	IN	_	39	mark	_	_
35	HLA-DO	hla-do	NN	NN	_	39	nsubj	_	_
36	is	be	VBZ	VBZ	_	39	cop	_	_
37	an	a	DT	DT	_	39	det	_	_
38	important	important	JJ	JJ	_	39	amod	_	_
39	modulator	modulator	NN	NN	_	33	ccomp	_	_
40	of	of	IN	IN	_	44	case	_	_
41	class	class	NN	NN	_	44	compound	_	_
42	II-restricted	ii-restricted	JJ	JJ	_	44	amod	_	_
43	antigen	antigen	NN	NN	_	44	compound	_	_
44	processing	processing	NN	NN	_	39	nmod	_	_
45	.	.	.	.	_	16	punct	_	_

1	NF-AT	nf-at	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	induced	induce	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	CAML-interacting	caml-interacting	JJ	JJ	_	7	amod	_	_
7	member	member	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	tumor	tumor	NN	NN	_	14	compound	_	_
11	necrosis	necrosis	NN	NN	_	14	compound	_	_
12	factor	factor	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	superfamily	superfamily	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	the	the	DT	DT	_	9	det	_	_
4	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
5	factor	factor	NN	NN	_	9	compound	_	_
6	of	of	IN	IN	_	9	amod	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	9	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NF-AT	nf-at	NN	NN	_	9	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	a	a	DT	DT	_	18	det	_	_
17	key	key	JJ	JJ	_	18	amod	_	_
18	event	event	NN	NN	_	0	root	_	_
19	underlying	underlie	VBG	VBG	_	18	acl	_	_
20	lymphocyte	lymphocyte	NN	NN	_	21	compound	_	_
21	action	action	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	CAML	caml	NN	NN	_	4	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	calcium-modulator	calcium-modulator	NN	NN	_	12	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cyclophilin	cyclophilin	NN	NN	_	9	compound	_	_
7	ligand	ligand	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	protein	protein	NN	NN	_	4	conj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	coinducer	coinducer	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-AT	nf-at	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	overexpressed	overexpress	VBN	VBN	_	12	advcl	_	_
18	in	in	IN	IN	_	21	case	_	_
19	Jurkat	jurkat	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	member	member	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	tumor	tumor	NN	NN	_	9	compound	_	_
6	necrosis	necrosis	NN	NN	_	9	compound	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	superfamily	superfamily	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	isolated	isolate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	virtue	virtue	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	affinity	affinity	NN	NN	_	13	nmod	_	_
17	for	for	IN	IN	_	18	case	_	_
18	CAML	caml	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	26	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	designated	designate	VBN	VBN	_	5	acl	_	_
8	TACI	taci	NN	NN	_	7	xcomp	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	transmembrane	transmembrane	JJ	JJ	_	11	amod	_	_
11	activator	activator	NN	NN	_	8	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CAML-interactor	caml-interactor	NN	NN	_	11	conj	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	,	,	,	,	_	1	punct	_	_
16	on	on	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	surface	surface	NN	NN	_	1	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	transfected	transfect	VBN	VBN	_	22	amod	_	_
21	Jurkat	jurkat	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	TACI-specific	taci-specific	JJ	JJ	_	25	amod	_	_
25	antibodies	antibody	NNS	NNS	_	22	nmod	_	_
26	led	lead	VBD	VBD	_	0	root	_	_
27	to	to	TO	TO	_	28	case	_	_
28	activation	activation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	28	nmod	_	_
33	NF-AT	nf-at	NN	NN	_	32	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	AP-1	ap-1	NN	NN	_	33	conj	_	_
36	,	,	,	,	_	33	punct	_	_
37	and	and	CC	CC	_	33	cc	_	_
38	NFkappaB	nfkappab	NN	NN	_	33	conj	_	_
39	.	.	.	.	_	26	punct	_	_

1	TACI-induced	taci-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-AT	nf-at	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	dominant-negative	dominant-negative	JJ	JJ	_	12	amod	_	_
11	CAML	caml	NN	NN	_	12	compound	_	_
12	mutant	mutant	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	thus	thus	RB	RB	_	15	advmod	_	_
15	implicating	implicate	VBG	VBG	_	7	advcl	_	_
16	CAML	caml	NN	NN	_	15	dobj	_	_
17	as	as	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	signaling	signal	VBG	VBG	_	20	amod	_	_
20	intermediate	intermediate	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Cooperation	cooperation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	8	case	_	_
5	an	a	DT	DT	_	8	det	_	_
6	activated	activate	VBN	VBN	_	8	amod	_	_
7	erythropoietin	erythropoietin	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	1	nmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
10	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Epo-dependent	epo-dependent	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	primary	primary	JJ	JJ	_	16	amod	_	_
16	erythroblasts	erythroblast	NNS	NNS	_	10	nmod	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	induces	induce	VBZ	VBZ	_	9	conj	_	_
19	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
20	Kit	kit	NN	NN	_	22	compound	_	_
21	ligand-dependent	ligand-dependent	JJ	JJ	_	22	amod	_	_
22	proliferation	proliferation	NN	NN	_	18	dobj	_	_
23	.	.	.	.	_	9	punct	_	_

1	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	9	nsubj	_	_
2	is	be	VBZ	VBZ	_	9	cop	_	_
3	a	a	DT	DT	_	9	det	_	_
4	myeloid-	myeloid-	JJ	JJ	_	9	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	B-cell	b-cell	NN	NN	_	4	conj	_	_
7	specific	specific	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	0	root	_	_
10	which	which	WDT	WDT	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	involved	involve	VBN	VBN	_	9	acl:relcl	_	_
14	in	in	IN	IN	_	18	case	_	_
15	Friend	friend	NN	NN	_	18	compound	_	_
16	virus-induced	virus-induced	JJ	JJ	_	18	amod	_	_
17	murine	murine	JJ	JJ	_	18	amod	_	_
18	erythroleukemia	erythroleukemia	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	pre-leukemic	pre-leukemic	JJ	JJ	_	3	amod	_	_
3	phase	phase	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Friend	friend	NN	NN	_	6	compound	_	_
6	erythroleukemia	erythroleukemia	NN	NN	_	3	nmod	_	_
7	results	result	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	erythropoietin	erythropoietin	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	EpoR	epor	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	by	by	IN	IN	_	27	case	_	_
18	the	the	DT	DT	_	27	det	_	_
19	spleen	spleen	NN	NN	_	27	compound	_	_
20	focus	focus	NN	NN	_	27	compound	_	_
21	forming	form	VBG	VBG	_	27	amod	_	_
22	virus	virus	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	SFFV	sffv	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	envelope	envelope	NN	NN	_	27	compound	_	_
27	glycoprotein	glycoprotein	NN	NN	_	9	nmod	_	_
28	,	,	,	,	_	9	punct	_	_
29	followed	follow	VBN	VBN	_	9	acl	_	_
30	by	by	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	emergence	emergence	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	leukemic	leukemic	JJ	JJ	_	35	amod	_	_
35	clones	clone	NNS	NNS	_	32	nmod	_	_
36	characterized	characterize	VBN	VBN	_	35	acl	_	_
37	by	by	IN	IN	_	38	case	_	_
38	overexpression	overexpression	NN	NN	_	36	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	Spi-1	spi-1	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	38	cc	_	_
42	mutation	mutation	NN	NN	_	38	conj	_	_
43	of	of	IN	IN	_	48	case	_	_
44	the	the	DT	DT	_	48	det	_	_
45	p53	p53	NN	NN	_	48	compound	_	_
46	tumor	tumor	NN	NN	_	48	compound	_	_
47	suppressor	suppressor	NN	NN	_	48	compound	_	_
48	gene	gene	NN	NN	_	42	nmod	_	_
49	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	developed	develop	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	heterologous	heterologous	JJ	JJ	_	5	amod	_	_
5	system	system	NN	NN	_	2	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	analyze	analyze	VB	VB	_	5	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	contribution	contribution	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	alterations	alteration	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	induction	induction	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	primary	primary	JJ	JJ	_	19	amod	_	_
18	erythroblast	erythroblast	NN	NN	_	19	compound	_	_
19	transformation	transformation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Avian	avian	JJ	JJ	_	2	amod	_	_
2	erythroblasts	erythroblast	NNS	NNS	_	11	nsubj	_	_
3	expressing	express	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	9	det	_	_
5	activated	activate	VBN	VBN	_	9	amod	_	_
6	mouse	mouse	NN	NN	_	9	compound	_	_
7	EpoR	epor	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	R129C	r129c	NN	NN	_	3	dobj	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	differentiated	differentiate	VBD	VBD	_	0	root	_	_
12	into	into	IN	IN	_	13	case	_	_
13	erythrocytes	erythrocyte	NNS	NNS	_	11	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	hEpo	hepo	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Spi-1	spi-1	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	this	this	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	differentiate	differentiate	VB	VB	_	9	acl	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	rescued	rescue	VBD	VBD	_	7	conj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	13	dobj	_	_
16	from	from	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	apoptotic	apoptotic	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	death	death	NN	NN	_	21	compound	_	_
21	program	program	NN	NN	_	13	nmod	_	_
22	normally	normally	RB	RB	_	23	advmod	_	_
23	induced	induce	VBN	VBN	_	21	acl	_	_
24	upon	upon	IN	IN	_	26	case	_	_
25	hEpo	hepo	NN	NN	_	26	compound	_	_
26	withdrawal	withdrawal	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	2	mark	_	_
2	devoid	devoid	JJ	JJ	_	12	advcl	_	_
3	of	of	IN	IN	_	5	case	_	_
4	any	any	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	itself	itself	PRP	PRP	_	2	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	mutant	mutant	JJ	JJ	_	11	amod	_	_
11	p53	p53	NN	NN	_	12	nsubj	_	_
12	cooperated	cooperate	VBD	VBD	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	Spi-1	spi-1	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	EpoR	epor	NN	NN	_	18	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	R129C	r129c	NN	NN	_	14	conj	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	reinforce	reinforce	VB	VB	_	12	xcomp	_	_
22	both	both	DT	DT	_	23	det	_	_
23	phenotypes	phenotype	NNS	NNS	_	21	dobj	_	_
24	.	.	.	.	_	12	punct	_	_

1	Analysis	analysis	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	erythroblasts	erythroblast	NNS	NNS	_	1	nmod	_	_
4	co-expressing	co-express	VBG	VBG	_	3	acl	_	_
5	Spi-1	spi-1	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	10	det	_	_
8	wild-type	wild-type	JJ	JJ	_	10	amod	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	EpoR	epor	NN	NN	_	5	conj	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	19	mark	_	_
13	differentiation	differentiation	NN	NN	_	14	compound	_	_
14	arrest	arrest	NN	NN	_	19	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	inhibition	inhibition	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	depended	depend	VBD	VBD	_	11	ccomp	_	_
20	on	on	IN	IN	_	22	case	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	cooperation	cooperation	NN	NN	_	19	nmod	_	_
23	between	between	IN	IN	_	24	case	_	_
24	Spi-1	spi-1	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	EpoR	epor	NN	NN	_	28	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	R129C	r129c	NN	NN	_	24	conj	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	cooperation	cooperation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	induce	induce	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	sustained	sustained	JJ	JJ	_	10	amod	_	_
10	proliferation	proliferation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	differentiation-blocked	differentiation-blocked	JJ	JJ	_	13	amod	_	_
13	erythroblasts	erythroblast	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	response	response	NN	NN	_	7	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	ligand	ligand	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	endogenous	endogenous	JJ	JJ	_	24	amod	_	_
22	tyrosine	tyrosine	NN	NN	_	24	compound	_	_
23	kinase	kinase	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	18	nmod	_	_
25	c-Kit	c-kit	NN	NN	_	24	dep	_	_
26	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	6	nsubj	_	_
6	requires	require	VBZ	VBZ	_	3	ccomp	_	_
7	signals	signal	NNS	NNS	_	6	dobj	_	_
8	emanating	emanate	VBG	VBG	_	7	acl	_	_
9	from	from	IN	IN	_	11	case	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	cytokine	cytokine	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	growth	growth	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	11	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	affect	affect	VB	VB	_	6	xcomp	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	survival	survival	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	proliferation	proliferation	NN	NN	_	19	conj	_	_
22	and	and	CC	CC	_	19	cc	_	_
23	differentiation	differentiation	NN	NN	_	24	compound	_	_
24	control	control	NN	NN	_	19	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	primary	primary	JJ	JJ	_	27	amod	_	_
27	erythroblasts	erythroblast	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	function	function	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	late	late	JJ	JJ	_	12	amod	_	_
12	phase	phase	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Friend	friend	NN	NN	_	15	compound	_	_
15	leukemia	leukemia	NN	NN	_	12	nmod	_	_
16	requires	require	VBZ	VBZ	_	3	ccomp	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	signaling	signaling	NN	NN	_	16	dobj	_	_
19	from	from	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	gp55-modified	gp55-modified	JJ	JJ	_	22	amod	_	_
22	EpoR	epor	NN	NN	_	18	nmod	_	_
23	generated	generate	VBN	VBN	_	22	acl	_	_
24	during	during	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	early	early	JJ	JJ	_	27	amod	_	_
27	phase	phase	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	disease	disease	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Cooperation	cooperation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	binding	bind	VBG	VBG	_	4	amod	_	_
4	sites	site	NNS	NNS	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	STAT6	stat6	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NF	nf	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B/rel	b/rel	NN	NN	_	6	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IL-4-induced	il-4-induced	JJ	JJ	_	14	amod	_	_
14	up-regulation	up-regulation	NN	NN	_	1	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	IgE	ige	NN	NN	_	20	compound	_	_
19	germline	germline	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Ig	ig	NN	NN	_	3	compound	_	_
2	heavy	heavy	JJ	JJ	_	3	amod	_	_
3	chain	chain	NN	NN	_	5	compound	_	_
4	class	class	NN	NN	_	5	compound	_	_
5	switching	switching	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	directed	direct	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	cytokines	cytokine	NNS	NNS	_	7	nmod	_	_
10	inducing	induce	VBG	VBG	_	9	acl	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	from	from	IN	IN	_	15	case	_	_
13	unrearranged	unrearranged	JJ	JJ	_	15	amod	_	_
14	CH	ch	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Subsequently	subsequently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	such	such	JJ	JJ	_	5	amod	_	_
4	primed	prime	VBN	VBN	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	undergo	undergo	VB	VB	_	0	root	_	_
8	switch	switch	NN	NN	_	9	compound	_	_
9	recombination	recombination	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	express	express	VB	VB	_	7	xcomp	_	_
12	the	the	DT	DT	_	15	det	_	_
13	selected	select	VBN	VBN	_	15	amod	_	_
14	new	new	JJ	JJ	_	15	amod	_	_
15	isotype	isotype	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	10	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	IgE	ige	NN	NN	_	7	compound	_	_
6	class	class	NN	NN	_	7	compound	_	_
7	switching	switching	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	IL-4	il-4	NN	NN	_	10	nsubj	_	_
10	activates	activate	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	14	det	_	_
12	IgE	ige	NN	NN	_	14	compound	_	_
13	germline	germline	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	dobj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	inducing	induce	VBG	VBG	_	10	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	interaction	interaction	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	STAT6	stat6	NN	NN	_	22	dep	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	IL-4STAT	il-4stat	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	with	with	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	responsive	responsive	JJ	JJ	_	31	amod	_	_
30	DNA	dna	NN	NN	_	31	compound	_	_
31	element	element	NN	NN	_	18	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	proximal	proximal	JJ	JJ	_	35	amod	_	_
35	region	region	NN	NN	_	16	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	promoter	promoter	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	describes	describe	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	characterization	characterization	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	additional	additional	JJ	JJ	_	10	amod	_	_
9	cis-acting	cis-acting	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	5	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	interact	interact	VBP	VBP	_	10	acl:relcl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	members	member	NNS	NNS	_	12	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	NF	nf	NN	NN	_	22	compound	_	_
18	kappa	kappa	NN	NN	_	22	compound	_	_
19	B/rel	b/rel	NN	NN	_	22	compound	_	_
20	transcription	transcription	NN	NN	_	22	compound	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	family	family	NN	NN	_	14	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	IL-4-independent	il-4-independent	JJ	JJ	_	26	amod	_	_
26	fashion	fashion	NN	NN	_	12	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	20	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nucleoprotein	nucleoprotein	NN	NN	_	9	compound	_	_
9	complex	complex	NN	NN	_	20	nsubj	_	_
10	formed	form	VBN	VBN	_	9	acl	_	_
11	on	on	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	upstream	upstream	JJ	JJ	_	14	amod	_	_
14	site	site	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	NF	nf	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B1	b1	NN	NN	_	14	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	contains	contain	VBZ	VBZ	_	5	ccomp	_	_
21	the	the	DT	DT	_	24	det	_	_
22	classical	classical	JJ	JJ	_	24	amod	_	_
23	p50/p65	p50/p65	NN	NN	_	24	compound	_	_
24	heterodimer	heterodimer	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	complex	complex	NN	NN	_	12	nsubj	_	_
3	on	on	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	proximal	proximal	JJ	JJ	_	6	amod	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	NF	nf	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B2	b2	NN	NN	_	2	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	appears	appear	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	composed	compose	VBN	VBN	_	12	xcomp	_	_
16	of	of	IN	IN	_	17	case	_	_
17	p50	p50	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	relB	relb	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	12	punct	_	_

1	IgE	ige	NN	NN	_	6	compound	_	_
2	germline	germline	NN	NN	_	6	compound	_	_
3	promoter	promoter	NN	NN	_	6	compound	_	_
4	reporter	reporter	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	18	nsubj	_	_
7	carrying	carry	VBG	VBG	_	6	acl	_	_
8	point	point	NN	NN	_	9	compound	_	_
9	mutations	mutation	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	NF	nf	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B2	b2	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	7	nmod	_	_
16	were	be	VBD	VBD	_	18	cop	_	_
17	largely	largely	RB	RB	_	18	advmod	_	_
18	unresponsive	unresponsive	JJ	JJ	_	0	root	_	_
19	to	to	TO	TO	_	21	case	_	_
20	IL-4	il-4	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	transient	transient	JJ	JJ	_	25	amod	_	_
24	transfection	transfection	NN	NN	_	25	compound	_	_
25	experiments	experiment	NNS	NNS	_	18	nmod	_	_
26	,	,	,	,	_	18	punct	_	_
27	while	while	IN	IN	_	38	mark	_	_
28	plasmids	plasmid	NNS	NNS	_	38	nsubj	_	_
29	with	with	IN	IN	_	31	case	_	_
30	similar	similar	JJ	JJ	_	31	amod	_	_
31	mutations	mutation	NNS	NNS	_	28	nmod	_	_
32	in	in	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	NF	nf	NN	NN	_	36	compound	_	_
35	kappa	kappa	NN	NN	_	36	compound	_	_
36	B1	b1	NN	NN	_	37	compound	_	_
37	site	site	NN	NN	_	31	nmod	_	_
38	responded	respond	VBD	VBD	_	18	advcl	_	_
39	to	to	TO	TO	_	41	case	_	_
40	cytokine	cytokine	NN	NN	_	41	compound	_	_
41	stimulation	stimulation	NN	NN	_	38	nmod	_	_
42	better	better	RBR	RBR	_	38	advmod	_	_
43	than	than	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	wild-type	wild-type	JJ	JJ	_	46	amod	_	_
46	promoter	promoter	NN	NN	_	42	nmod	_	_
47	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	NF	nf	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B2	b2	NN	NN	_	5	compound	_	_
5	effect	effect	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	dependent	dependent	JJ	JJ	_	0	root	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	STAT6	stat6	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	demonstrating	demonstrate	VBG	VBG	_	7	xcomp	_	_
18	that	that	IN	IN	_	25	mark	_	_
19	the	the	DT	DT	_	23	det	_	_
20	NF	nf	NN	NN	_	23	compound	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B2	b2	NN	NN	_	23	compound	_	_
23	motif	motif	NN	NN	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	necessary	necessary	JJ	JJ	_	17	ccomp	_	_
26	but	but	CC	CC	_	25	cc	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	sufficient	sufficient	JJ	JJ	_	25	conj	_	_
29	for	for	IN	IN	_	30	mark	_	_
30	mediating	mediate	VBG	VBG	_	25	advcl	_	_
31	cytokine	cytokine	NN	NN	_	32	compound	_	_
32	up-regulation	up-regulation	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	combination	combination	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	NF	nf	NN	NN	_	12	compound	_	_
9	kappa	kappa	NN	NN	_	12	compound	_	_
10	B/rel	b/rel	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	17	det	_	_
15	STAT6	stat6	NN	NN	_	17	compound	_	_
16	response	response	NN	NN	_	17	compound	_	_
17	element	element	NN	NN	_	12	conj	_	_
18	conferred	confer	VBD	VBD	_	0	root	_	_
19	IL-4	il-4	NN	NN	_	20	compound	_	_
20	inducibility	inducibility	NN	NN	_	18	dobj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	heterologous	heterologous	JJ	JJ	_	25	amod	_	_
24	minimal	minimal	JJ	JJ	_	25	amod	_	_
25	promoter	promoter	NN	NN	_	18	nmod	_	_
26	,	,	,	,	_	18	punct	_	_
27	while	while	IN	IN	_	31	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	individual	individual	JJ	JJ	_	30	amod	_	_
30	sites	site	NNS	NNS	_	31	nsubj	_	_
31	had	have	VBD	VBD	_	18	advcl	_	_
32	no	no	DT	DT	_	33	neg	_	_
33	effect	effect	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	available	available	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	11	det	_	_
7	NF	nf	NN	NN	_	11	compound	_	_
8	kappa	kappa	NN	NN	_	11	compound	_	_
9	B2	b2	NN	NN	_	11	compound	_	_
10	nucleoprotein	nucleoprotein	NN	NN	_	11	compound	_	_
11	complex	complex	NN	NN	_	13	nsubj	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	cooperate	cooperate	VB	VB	_	4	ccomp	_	_
14	with	with	IN	IN	_	16	case	_	_
15	DNA-bound	dna-bound	JJ	JJ	_	16	amod	_	_
16	STAT6	stat6	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	achieve	achieve	VB	VB	_	13	xcomp	_	_
19	IL-4-dependent	il-4-dependent	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	human	human	JJ	JJ	_	26	amod	_	_
24	IgE	ige	NN	NN	_	26	compound	_	_
25	germline	germline	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Dual	dual	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	LPS	lps	NN	NN	_	5	compound	_	_
5	antibodies	antibody	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	uptake	uptake	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	LPS	lps	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	LPS-induced	lps-induced	JJ	JJ	_	14	amod	_	_
13	proinflammatory	proinflammatory	JJ	JJ	_	12	dep	_	_
14	functions	function	NNS	NNS	_	8	conj	_	_
15	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	phagocytes	phagocyte	NNS	NNS	_	3	nsubj	_	_
3	recognize	recognize	VBP	VBP	_	0	root	_	_
4	bacterial	bacterial	JJ	JJ	_	5	amod	_	_
5	LPS	lps	NN	NN	_	3	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	endotoxin	endotoxin	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	through	through	IN	IN	_	11	case	_	_
10	membrane	membrane	NN	NN	_	11	compound	_	_
11	CD14	cd14	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	mCD14	mcd14	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	a	a	DT	DT	_	19	det	_	_
17	proinflammatory	proinflammatory	JJ	JJ	_	19	amod	_	_
18	LPS	lps	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	11	appos	_	_
20	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	tested	test	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	anti-LPS	anti-lps	JJ	JJ	_	8	amod	_	_
8	Abs	ab	NNS	NNS	_	9	nsubj	_	_
9	neutralize	neutralize	VBP	VBP	_	5	ccomp	_	_
10	endotoxin	endotoxin	NN	NN	_	9	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	blocking	block	VBG	VBG	_	9	advcl	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	uptake	uptake	NN	NN	_	12	dobj	_	_
15	through	through	IN	IN	_	16	case	_	_
16	mCD14	mcd14	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Ab-associated	ab-associated	JJ	JJ	_	2	amod	_	_
2	changes	change	NNS	NNS	_	12	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	uptake	uptake	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	distribution	distribution	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	FITC-LPS	fitc-lps	NN	NN	_	5	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	assessed	assess	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	flow	flow	NN	NN	_	15	compound	_	_
15	cytometry	cytometry	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	laser	laser	NN	NN	_	20	compound	_	_
18	scanning	scanning	NN	NN	_	20	compound	_	_
19	confocal	confocal	JJ	JJ	_	20	amod	_	_
20	microscopy	microscopy	NN	NN	_	15	conj	_	_
21	in	in	IN	IN	_	27	case	_	_
22	human	human	JJ	JJ	_	27	amod	_	_
23	CD14-transfected	cd14-transfected	JJ	JJ	_	27	amod	_	_
24	Chinese	chinese	JJ	JJ	_	27	amod	_	_
25	hamster	hamster	NN	NN	_	27	compound	_	_
26	ovary	ovary	JJ	JJ	_	27	amod	_	_
27	fibroblasts	fibroblast	NNS	NNS	_	12	nmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	CHO-CD14	cho-cd14	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	human	human	JJ	JJ	_	36	amod	_	_
34	peripheral	peripheral	JJ	JJ	_	36	amod	_	_
35	blood	blood	NN	NN	_	36	compound	_	_
36	monocytes	monocyte	NNS	NNS	_	27	conj	_	_
37	.	.	.	.	_	12	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	core-	core-	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	O-side	o-side	JJ	JJ	_	5	amod	_	_
5	chain-specific	chain-specific	JJ	JJ	_	2	conj	_	_
6	mAbs	mab	NNS	NNS	_	2	dep	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	mCD14-mediated	mcd14-mediated	JJ	JJ	_	10	amod	_	_
9	LPS	lps	NN	NN	_	10	compound	_	_
10	uptake	uptake	NN	NN	_	7	dobj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	both	both	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	types	type	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	presence	presence	NN	NN	_	7	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	serum	serum	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	O-side	o-side	JJ	JJ	_	3	amod	_	_
2	chain-specific	chain-specific	JJ	JJ	_	3	amod	_	_
3	mAb	mab	NN	NN	_	5	nsubj	_	_
4	concurrently	concurrently	RB	RB	_	5	advmod	_	_
5	enhanced	enhance	VBD	VBD	_	0	root	_	_
6	complement-dependent	complement-dependent	JJ	JJ	_	8	amod	_	_
7	LPS	lps	NN	NN	_	8	compound	_	_
8	uptake	uptake	NN	NN	_	5	dobj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
11	through	through	IN	IN	_	13	case	_	_
12	complement	complement	NN	NN	_	13	compound	_	_
13	receptor-1	receptor-1	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CR1	cr1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	uptake	uptake	NN	NN	_	8	conj	_	_
19	by	by	IN	IN	_	21	case	_	_
20	CHO-CD14	cho-cd14	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	involving	involve	VBG	VBG	_	21	acl	_	_
23	another	another	DT	DT	_	28	det	_	_
24	heat-labile	heat-labile	JJ	JJ	_	26	amod	_	_
25	serum	serum	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	28	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	s	s	NNS	NNS	_	22	dobj	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	28	cc	_	_
31	cell-associated	cell-associated	JJ	JJ	_	33	amod	_	_
32	recognition	recognition	NN	NN	_	33	compound	_	_
33	molecule	molecule	NN	NN	_	35	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	s	s	NNS	NNS	_	28	conj	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	5	punct	_	_

1	Core-specific	core-specific	JJ	JJ	_	2	amod	_	_
2	mAb	mab	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	mCD14-mediated	mcd14-mediated	JJ	JJ	_	5	amod	_	_
5	uptake	uptake	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	homologous	homologous	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	heterologous	heterologous	JJ	JJ	_	7	conj	_	_
10	LPS	lps	NN	NN	_	7	dep	_	_
11	,	,	,	,	_	3	punct	_	_
12	while	while	IN	IN	_	13	mark	_	_
13	producing	produce	VBG	VBG	_	3	advcl	_	_
14	less	less	RBR	RBR	_	15	advmod	_	_
15	concurrent	concurrent	JJ	JJ	_	16	amod	_	_
16	enhancement	enhancement	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	non-mCD14-mediated	non-mcd14-mediated	JJ	JJ	_	20	amod	_	_
19	LPS	lps	NN	NN	_	20	compound	_	_
20	uptake	uptake	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	modulation	modulation	NN	NN	_	11	nsubjpass	_	_
3	by	by	IN	IN	_	5	case	_	_
4	anti-LPS	anti-lps	JJ	JJ	_	5	amod	_	_
5	mAbs	mab	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	mCD14-mediated	mcd14-mediated	JJ	JJ	_	9	amod	_	_
8	LPS	lps	NN	NN	_	9	compound	_	_
9	uptake	uptake	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	inhibition	inhibition	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	21	case	_	_
15	LPS-induced	lps-induced	JJ	JJ	_	17	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factor-kappaB	factor-kappab	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	translocation	translocation	NN	NN	_	13	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	24	compound	_	_
24	secretion	secretion	NN	NN	_	21	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	CHO-CD14	cho-cd14	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	monocytes	monocyte	NNS	NNS	_	27	conj	_	_
30	,	,	,	,	_	21	punct	_	_
31	respectively	respectively	RB	RB	_	21	advmod	_	_
32	,	,	,	,	_	11	punct	_	_
33	while	while	IN	IN	_	40	mark	_	_
34	mAb	mab	NN	NN	_	35	compound	_	_
35	enhancement	enhancement	NN	NN	_	40	nsubj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	non-mCD14-mediated	non-mcd14-mediated	JJ	JJ	_	39	amod	_	_
38	LPS	lps	NN	NN	_	39	compound	_	_
39	uptake	uptake	NN	NN	_	35	nmod	_	_
40	stimulated	stimulate	VBD	VBD	_	11	advcl	_	_
41	these	these	DT	DT	_	42	det	_	_
42	activities	activity	NNS	NNS	_	40	dobj	_	_
43	.	.	.	.	_	11	punct	_	_

1	LPS-specific	lps-specific	JJ	JJ	_	2	amod	_	_
2	Abs	ab	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	mediate	mediate	VBP	VBP	_	0	root	_	_
5	anti-inflammatory	anti-inflammatory	JJ	JJ	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	proinflammatory	proinflammatory	JJ	JJ	_	5	conj	_	_
8	functions	function	NNS	NNS	_	5	dep	_	_
9	,	,	,	,	_	4	punct	_	_
10	respectively	respectively	RB	RB	_	4	advmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	preventing	prevent	VBG	VBG	_	4	advcl	_	_
14	target	target	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	uptake	uptake	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	LPS	lps	NN	NN	_	16	nmod	_	_
19	through	through	IN	IN	_	20	case	_	_
20	mCD14	mcd14	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	augmenting	augment	VBG	VBG	_	13	conj	_	_
23	uptake	uptake	NN	NN	_	22	dobj	_	_
24	through	through	IN	IN	_	25	case	_	_
25	CR1	cr1	NN	NN	_	23	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	other	other	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	receptors	receptor	NNS	NNS	_	25	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Phospholipase	phospholipase	NN	NN	_	3	compound	_	_
2	C	c	NN	NN	_	3	compound	_	_
3	gamma	gamma	NN	NN	_	0	root	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	overexpression	overexpression	NN	NN	_	3	dep	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	activation	activation	NN	NN	_	3	conj	_	_
8	induced	induce	VBN	VBN	_	3	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	interferon	interferon	NN	NN	_	11	compound	_	_
11	beta	beta	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
16	:	:	:	:	_	3	punct	_	_
17	an	a	DT	DT	_	19	det	_	_
18	ISGF3-independent	isgf3-independent	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	3	dep	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interferons	interferon	NNS	NNS	_	2	nsubj	_	_
2	exert	exert	VBP	VBP	_	0	root	_	_
3	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
4	antiviral	antiviral	JJ	JJ	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	antiproliferative	antiproliferative	JJ	JJ	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	immunoregulatory	immunoregulatory	JJ	JJ	_	4	conj	_	_
9	activities	activity	NNS	NNS	_	4	dep	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	stimulating	stimulate	VBG	VBG	_	2	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	several	several	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	genes	gene	NNS	NNS	_	3	nsubj	_	_
3	disclose	disclose	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	common	common	JJ	JJ	_	6	amod	_	_
6	element	element	NN	NN	_	3	dobj	_	_
7	within	within	IN	IN	_	9	case	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	promoters	promoter	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	defined	define	VBN	VBN	_	6	acl	_	_
12	Interferon	interferon	NN	NN	_	15	compound	_	_
13	Stimulated	stimulated	NN	NN	_	15	compound	_	_
14	Response	response	NN	NN	_	15	compound	_	_
15	Element	element	NN	NN	_	11	xcomp	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	ISRE	isre	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	6	punct	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	binds	bind	VBZ	VBZ	_	6	acl:relcl	_	_
22	a	a	DT	DT	_	26	det	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	26	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	s	s	NNS	NNS	_	21	dobj	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	translocated	translocate	VBN	VBN	_	26	acl	_	_
29	from	from	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	cytoplasm	cytoplasm	NN	NN	_	28	nmod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	31	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	ISGF3	isgf3	NN	NN	_	26	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	after	after	IN	IN	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	binding	binding	NN	NN	_	21	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	interferon	interferon	NN	NN	_	40	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	IFN	ifn	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	to	to	TO	TO	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	specific	specific	JJ	JJ	_	49	amod	_	_
49	receptor	receptor	NN	NN	_	40	nmod	_	_
50	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	induction	induction	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	synthesis	synthesis	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	hydrolytic	hydrolytic	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	8	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	phospholipase	phospholipase	NN	NN	_	17	compound	_	_
16	C	c	NN	NN	_	17	compound	_	_
17	gamma	gamma	NN	NN	_	8	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	PLC	plc	NN	NN	_	21	compound	_	_
21	gamma	gamma	NN	NN	_	17	appos	_	_
22	1	1	CD	CD	_	21	nummod	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	in	in	IN	IN	_	27	case	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	IFN-beta	ifn-beta	NN	NN	_	5	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	level	level	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	PLC	plc	NN	NN	_	6	compound	_	_
6	gamma	gamma	NN	NN	_	3	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	becomes	become	VBZ	VBZ	_	0	root	_	_
9	evident	evident	JJ	JJ	_	8	xcomp	_	_
10	after	after	IN	IN	_	12	case	_	_
11	90	90	CD	CD	_	12	nummod	_	_
12	min	min	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IFN-beta	ifn-beta	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	still	still	RB	RB	_	19	advmod	_	_
19	detectable	detectable	JJ	JJ	_	8	conj	_	_
20	after	after	IN	IN	_	22	case	_	_
21	24	24	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Neither	neither	CC	CC	_	6	cc:preconj	_	_
2	the	the	DT	DT	_	6	det	_	_
3	PLC	plc	NN	NN	_	4	compound	_	_
4	gamma	gamma	NN	NN	_	6	compound	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	overexpression	overexpression	NN	NN	_	18	nsubj	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IFN	ifn	NN	NN	_	7	nmod	_	_
10	nor	nor	CC	CC	_	6	cc	_	_
11	the	the	DT	DT	_	14	det	_	_
12	increased	increase	VBN	VBN	_	14	amod	_	_
13	hydrolytic	hydrolytic	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	6	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	enzyme	enzyme	NN	NN	_	14	nmod	_	_
18	appear	appear	VBP	VBP	_	0	root	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	affected	affect	VBN	VBN	_	18	xcomp	_	_
22	by	by	IN	IN	_	23	case	_	_
23	pretreatment	pretreatment	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	with	with	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	protein	protein	NN	NN	_	32	compound	_	_
30	tyrosine	tyrosine	NN	NN	_	31	compound	_	_
31	kinase	kinase	NN	NN	_	32	compound	_	_
32	inhibitor	inhibitor	NN	NN	_	23	nmod	_	_
33	genistein	genistein	NN	NN	_	32	dep	_	_
34	,	,	,	,	_	32	punct	_	_
35	which	which	WDT	WDT	_	37	nsubjpass	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	known	know	VBN	VBN	_	32	acl:relcl	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	prevent	prevent	VB	VB	_	37	xcomp	_	_
40	the	the	DT	DT	_	41	det	_	_
41	association	association	NN	NN	_	39	dobj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	ISGF3	isgf3	NN	NN	_	44	compound	_	_
44	components	component	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
9	IFN-beta	ifn-beta	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	activate	activate	VB	VB	_	3	ccomp	_	_
12	other	other	JJ	JJ	_	16	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	s	s	NNS	NNS	_	11	dobj	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	distinct	distinct	JJ	JJ	_	16	amod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	ISGF3	isgf3	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	regulate	regulate	VB	VB	_	11	xcomp	_	_
23	PLC	plc	NN	NN	_	24	compound	_	_
24	gamma	gamma	NN	NN	_	26	compound	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	expression	expression	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ability	ability	NN	NN	_	20	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	enzyme	enzyme	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	hydrolyse	hydrolyse	VB	VB	_	5	acl	_	_
11	PIP2	pip2	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	5	punct	_	_
13	also	also	RB	RB	_	20	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	20	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	genistein	genistein	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	20	punct	_	_
20	implies	imply	VBZ	VBZ	_	0	root	_	_
21	the	the	DT	DT	_	22	det	_	_
22	possibility	possibility	NN	NN	_	20	dobj	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	this	this	DT	DT	_	25	det	_	_
25	enzyme	enzyme	NN	NN	_	27	nsubj	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	exert	exert	VB	VB	_	22	ccomp	_	_
28	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
29	hydrolytic	hydrolytic	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	27	dobj	_	_
31	independently	independently	RB	RB	_	27	advmod	_	_
32	of	of	IN	IN	_	36	case	_	_
33	protein	protein	NN	NN	_	35	compound	_	_
34	tyrosine	tyrosine	NN	NN	_	35	compound	_	_
35	kinase	kinase	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	20	punct	_	_

1	Interleukin-7	interleukin-7	NN	NN	_	2	nsubj	_	_
2	upregulates	upregulate	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	interleukin-2-gene	interleukin-2-gene	JJ	JJ	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	activated	activate	VBN	VBN	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	level	level	NN	NN	_	2	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	enhancing	enhance	VBG	VBG	_	2	advcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activities	activity	NNS	NNS	_	16	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	activated	activate	VBN	VBN	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	activator	activator	NN	NN	_	31	compound	_	_
31	protein-1	protein-1	NN	NN	_	24	conj	_	_
32	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	studied	study	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	stromal-derived	stromal-derived	JJ	JJ	_	14	amod	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	interleukin-7	interleukin-7	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-7	il-7	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IL-2-gene	il-2-gene	JJ	JJ	_	21	compound	_	_
21	regulation	regulation	NN	NN	_	9	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Production	production	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	1	nmod	_	_
4	requires	require	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	formation	formation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IL-2-gene	il-2-gene	JJ	JJ	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	T-cell	t-cell	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	TCR	tcr	NN	NN	_	6	compound	_	_
5	)	)	-RRB-	-RRB-	_	6	punct	_	_
6	/CD3	/cd3	NN	NN	_	7	compound	_	_
7	engagement	engagement	NN	NN	_	8	nsubj	_	_
8	results	result	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	NFAT	nfat	NN	NN	_	14	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	14	punct	_	_
23	activator	activator	NN	NN	_	24	compound	_	_
24	protein-1	protein-1	NN	NN	_	14	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	AP-1	ap-1	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	14	punct	_	_
29	and	and	CC	CC	_	14	cc	_	_
30	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
31	factor	factor	NN	NN	_	32	compound	_	_
32	kappaB	kappab	NN	NN	_	14	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	NFkappaB	nfkappab	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	8	punct	_	_
37	whereas	whereas	IN	IN	_	46	mark	_	_
38	the	the	DT	DT	_	41	det	_	_
39	CD28	cd28	NN	NN	_	41	compound	_	_
40	responsive	responsive	JJ	JJ	_	41	amod	_	_
41	complex	complex	NN	NN	_	46	nsubjpass	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	CD28RC	cd28rc	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	is	be	VBZ	VBZ	_	46	auxpass	_	_
46	activated	activate	VBN	VBN	_	8	advcl	_	_
47	in	in	IN	IN	_	48	case	_	_
48	response	response	NN	NN	_	46	nmod	_	_
49	to	to	TO	TO	_	52	case	_	_
50	the	the	DT	DT	_	52	det	_	_
51	CD28	cd28	NN	NN	_	52	compound	_	_
52	signal	signal	NN	NN	_	48	nmod	_	_
53	.	.	.	.	_	8	punct	_	_

1	Costimulation	costimulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	phytohemagglutinin/anti-CD28	phytohemagglutinin/anti-cd28	JJ	JJ	_	6	amod	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	IL-7	il-7	NN	NN	_	1	nmod	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	14	det	_	_
11	fivefold	fivefold	RB	RB	_	12	advmod	_	_
12	enhanced	enhance	VBN	VBN	_	14	amod	_	_
13	IL-2-mRNA	il-2-mrna	NN	NN	_	14	compound	_	_
14	accumulation	accumulation	NN	NN	_	9	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	a	a	DT	DT	_	20	det	_	_
17	2.5-fold	2.5-fold	RB	RB	_	18	advmod	_	_
18	enhanced	enhance	VBN	VBN	_	20	amod	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	secretion	secretion	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IL-2-gene	il-2-gene	JJ	JJ	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	rate	rate	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	increased	increase	VBN	VBN	_	0	root	_	_
7	3.4-fold	3.4-fold	RB	RB	_	6	dobj	_	_
8	,	,	,	,	_	6	punct	_	_
9	indicating	indicate	VBG	VBG	_	6	advcl	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	the	the	DT	DT	_	12	det	_	_
12	effect	effect	NN	NN	_	18	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-7	il-7	NN	NN	_	12	nmod	_	_
15	is	be	VBZ	VBZ	_	18	auxpass	_	_
16	in	in	IN	IN	_	17	case	_	_
17	part	part	NN	NN	_	18	nmod	_	_
18	mediated	mediate	VBN	VBN	_	9	ccomp	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	8	nsubj	_	_
4	underlying	underlie	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-7	il-7	NN	NN	_	7	compound	_	_
7	effect	effect	NN	NN	_	4	dobj	_	_
8	involve	involve	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	upregulation	upregulation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	DNA	dna	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NFAT	nfat	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	60	60	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	10	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	AP-1	ap-1	NN	NN	_	10	conj	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	120	120	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	23	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	8	punct	_	_
29	without	without	IN	IN	_	30	mark	_	_
30	affecting	affect	VBG	VBG	_	8	advcl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	activities	activity	NNS	NNS	_	30	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	NFkappaB	nfkappab	NN	NN	_	32	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	CD28RC	cd28rc	NN	NN	_	34	conj	_	_
37	,	,	,	,	_	8	punct	_	_
38	which	which	WDT	WDT	_	40	nsubjpass	_	_
39	was	be	VBD	VBD	_	40	auxpass	_	_
40	confirmed	confirm	VBN	VBN	_	8	dep	_	_
41	by	by	IN	IN	_	43	case	_	_
42	transfection	transfection	NN	NN	_	43	compound	_	_
43	assays	assay	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-7-induced	il-7-induced	JJ	JJ	_	7	amod	_	_
7	enhancement	enhancement	NN	NN	_	16	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	AP-1-DNA	ap-1-dna	JJ	JJ	_	12	amod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	cyclosporin	cyclosporin	NN	NN	_	16	nmod:npmod	_	_
16	A-sensitive	a-sensitive	JJ	JJ	_	3	ccomp	_	_
17	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	AP-1	ap-1	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	part	part	NN	NN	_	11	advcl	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	NFAT	nfat	NN	NN	_	8	compound	_	_
8	complex	complex	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	conclude	conclude	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	17	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-7-signaling	il-7-signaling	JJ	JJ	_	15	amod	_	_
15	pathway	pathway	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	involved	involve	VBN	VBN	_	11	ccomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	fos	fos	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	jun	jun	NN	NN	_	23	conj	_	_
26	proteins	protein	NNS	NNS	_	23	dep	_	_
27	of	of	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	30	nmod	_	_
29	AP-1	ap-1	NN	NN	_	30	nsubj	_	_
30	consists	consist	VBZ	VBZ	_	23	acl:relcl	_	_
31	.	.	.	.	_	11	punct	_	_

1	Monochloramine	monochloramine	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	phorbol	phorbol	NN	NN	_	8	compound	_	_
4	ester-inducible	ester-inducible	JJ	JJ	_	8	amod	_	_
5	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
6	respiratory	respiratory	NN	NN	_	8	compound	_	_
7	burst	burst	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	2	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	T	t	NN	NN	_	14	compound	_	_
11	cell	cell	NN	NN	_	14	compound	_	_
12	interleukin-2	interleukin-2	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	8	conj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	inhibiting	inhibit	VBG	VBG	_	2	advcl	_	_
17	inducible	inducible	JJ	JJ	_	21	amod	_	_
18	protein	protein	NN	NN	_	20	compound	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	C	c	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	16	dobj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Monochloramine	monochloramine	NN	NN	_	2	compound	_	_
2	derivatives	derivative	NNS	NNS	_	7	nsubj	_	_
3	are	be	VBP	VBP	_	7	cop	_	_
4	long	long	RB	RB	_	5	advmod	_	_
5	lived	live	VBN	VBN	_	7	amod	_	_
6	physiological	physiological	JJ	JJ	_	5	dep	_	_
7	oxidants	oxidant	NNS	NNS	_	0	root	_	_
8	produced	produce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	neutrophils	neutrophil	NNS	NNS	_	8	nmod	_	_
11	during	during	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	respiratory	respiratory	JJ	JJ	_	14	amod	_	_
14	burst	burst	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	22	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	chemically	chemically	RB	RB	_	5	advmod	_	_
5	prepared	prepare	VBN	VBN	_	6	amod	_	_
6	monochloramine	monochloramine	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NH2Cl	nh2cl	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	on	on	IN	IN	_	13	case	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	C	c	NN	NN	_	2	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PKC	pkc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	PKC-mediated	pkc-mediated	JJ	JJ	_	20	amod	_	_
19	cellular	cellular	JJ	JJ	_	20	amod	_	_
20	responses	response	NNS	NNS	_	13	conj	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	studied	study	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	27	case	_	_
24	elicited	elicited	JJ	JJ	_	27	amod	_	_
25	rat	rat	NN	NN	_	27	compound	_	_
26	peritoneal	peritoneal	NN	NN	_	27	compound	_	_
27	neutrophils	neutrophil	NNS	NNS	_	22	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	human	human	JJ	JJ	_	32	amod	_	_
30	Jurkat	jurkat	NN	NN	_	32	compound	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	conj	_	_
33	.	.	.	.	_	22	punct	_	_

1	Neutrophils	neutrophil	NNS	NNS	_	9	nsubj	_	_
2	pretreated	pretreat	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	4	case	_	_
4	NH2Cl	nh2cl	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	30-50	30-50	CD	CD	_	7	nummod	_	_
7	microM	microm	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	marked	marked	JJ	JJ	_	12	amod	_	_
12	decrease	decrease	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	respiratory	respiratory	JJ	JJ	_	17	amod	_	_
16	burst	burst	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	12	nmod	_	_
18	induced	induce	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	22	case	_	_
20	phorbol	phorbol	NN	NN	_	22	compound	_	_
21	12-myristate	12-myristate	NN	NN	_	22	compound	_	_
22	13-acetate	13-acetate	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PMA	pma	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	22	punct	_	_
27	which	which	WDT	WDT	_	32	nsubj	_	_
28	is	be	VBZ	VBZ	_	32	cop	_	_
29	a	a	DT	DT	_	32	det	_	_
30	potent	potent	JJ	JJ	_	32	amod	_	_
31	PKC	pkc	NN	NN	_	32	compound	_	_
32	activator	activator	NN	NN	_	22	acl:relcl	_	_
33	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	7	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	however	however	RB	RB	_	7	advmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	viable	viable	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	showed	show	VBD	VBD	_	7	conj	_	_
10	a	a	DT	DT	_	13	det	_	_
11	complete	complete	JJ	JJ	_	13	amod	_	_
12	respiratory	respiratory	JJ	JJ	_	13	amod	_	_
13	burst	burst	NN	NN	_	9	dobj	_	_
14	upon	upon	IN	IN	_	17	case	_	_
15	arachidonic	arachidonic	JJ	JJ	_	17	amod	_	_
16	acid	acid	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	induces	induce	VBZ	VBZ	_	17	acl:relcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	respiratory	respiratory	JJ	JJ	_	23	amod	_	_
23	burst	burst	NN	NN	_	20	dobj	_	_
24	by	by	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	PKC-independent	pkc-independent	JJ	JJ	_	27	amod	_	_
27	mechanism	mechanism	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NH2Cl-treated	nh2cl-treated	JJ	JJ	_	3	amod	_	_
3	neutrophils	neutrophil	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	decrease	decrease	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	PKC	pkc	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	PMA-induced	pma-induced	JJ	JJ	_	13	amod	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	47-kDa	47-kda	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	corresponds	correspond	VBZ	VBZ	_	17	acl:relcl	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cytosolic	cytosolic	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NADPH	nadph	NN	NN	_	27	compound	_	_
27	oxidase	oxidase	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	p47	p47	NN	NN	_	31	compound	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	phox	phox	NN	NN	_	24	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	4	punct	_	_

1	Jurkat	jurkat	NN	NN	_	3	compound	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	11	nsubj	_	_
4	pretreated	pretreat	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	6	case	_	_
6	NH2Cl	nh2cl	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	20-70	20-70	CD	CD	_	9	nummod	_	_
9	microM	microm	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	13	det	_	_
13	decrease	decrease	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	interleukin-2	interleukin-2	NN	NN	_	16	nmod	_	_
20	receptor	receptor	NN	NN	_	22	compound	_	_
21	alpha	alpha	NN	NN	_	22	compound	_	_
22	chain	chain	NN	NN	_	19	dep	_	_
23	following	follow	VBG	VBG	_	11	dep	_	_
24	PMA	pma	NN	NN	_	25	compound	_	_
25	stimulation	stimulation	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	decrease	decrease	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	PKC	pkc	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	factor-kappaB	factor-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	11	conj	_	_
17	,	,	,	,	_	7	punct	_	_
18	also	also	RB	RB	_	20	advmod	_	_
19	without	without	IN	IN	_	20	case	_	_
20	loss	loss	NN	NN	_	7	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	viability	viability	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	NH2Cl	nh2cl	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
7	PKC-mediated	pkc-mediated	JJ	JJ	_	9	amod	_	_
8	cellular	cellular	JJ	JJ	_	9	amod	_	_
9	responses	response	NNS	NNS	_	6	dobj	_	_
10	through	through	IN	IN	_	11	case	_	_
11	inhibition	inhibition	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	inducible	inducible	JJ	JJ	_	16	amod	_	_
15	PKC	pkc	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	Vpr	vpr	NN	NN	_	3	nsubj	_	_
3	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
8	through	through	IN	IN	_	9	case	_	_
9	regulation	regulation	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
12	factor	factor	NN	NN	_	14	compound	_	_
13	kappa	kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	16	punct	_	_
16	see	see	VB	VB	_	3	parataxis	_	_
17	comments	comment	NNS	NNS	_	16	dobj	_	_
18	-RSB-	-rsb-	-RRB-	-RRB-	_	16	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
3	accessory	accessory	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	product	product	NN	NN	_	8	nsubj	_	_
6	Vpr	vpr	NN	NN	_	5	dep	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	influence	influence	VB	VB	_	0	root	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	pathogenesis	pathogenesis	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	affecting	affect	VBG	VBG	_	8	advcl	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	replication	replication	NN	NN	_	12	dobj	_	_
15	as	as	RB	RB	_	14	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	host	host	NN	NN	_	19	compound	_	_
19	cell	cell	NN	NN	_	14	conj	_	_
20	transcription	transcription	NN	NN	_	19	dep	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	proliferation	proliferation	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Vpr	vpr	NN	NN	_	5	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	host	host	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	confirm	confirm	VBP	VBP	_	3	conj	_	_
14	that	that	IN	IN	_	16	mark	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	influences	influence	VBZ	VBZ	_	13	ccomp	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	proliferation	proliferation	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	have	have	VBP	VBP	_	6	aux	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	Vpr	vpr	NN	NN	_	9	nsubj	_	_
9	modulates	modulate	VBZ	VBZ	_	6	ccomp	_	_
10	T-cell	t-cell	NN	NN	_	16	compound	_	_
11	receptor	receptor	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	TCR	tcr	NN	NN	_	16	compound	_	_
14	)	)	-RRB-	-RRB-	_	16	punct	_	_
15	-triggered	-triggered	JJ	JJ	_	16	amod	_	_
16	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	manner	manner	NN	NN	_	9	nmod	_	_
20	similar	similar	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	that	that	DT	DT	_	20	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	glucocorticoids	glucocorticoid	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	9	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	TCR-mediated	tcr-mediated	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	Vpr	vpr	NN	NN	_	9	nsubj	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
11	whereas	whereas	IN	IN	_	17	mark	_	_
12	in	in	IN	IN	_	14	case	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	presence	presence	NN	NN	_	17	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	Vpr	vpr	NN	NN	_	17	nsubj	_	_
17	interrupts	interrupt	VBZ	VBZ	_	9	advcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	expected	expect	VBN	VBN	_	20	amod	_	_
20	induction	induction	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	apoptosis	apoptosis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	linked	link	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	Vpr	vpr	NN	NN	_	9	compound	_	_
9	suppression	suppression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	via	via	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	6	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	I	i	NN	NN	_	20	compound	_	_
19	kappa	kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	an	a	DT	DT	_	23	det	_	_
23	inhibitor	inhibitor	NN	NN	_	20	appos	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Further	further	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Vpr	vpr	NN	NN	_	4	nsubj	_	_
4	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-2	il-2	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	IL-12	il-12	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	TNF	tnf	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	7	conj	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	IL-4	il-4	NN	NN	_	7	conj	_	_
17	,	,	,	,	_	7	punct	_	_
18	all	all	DT	DT	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	nmod:npmod	_	_
23	B-dependent	b-dependent	JJ	JJ	_	7	acl:relcl	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Vpr	vpr	NN	NN	_	2	nmod	_	_
5	could	could	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	reversed	reverse	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	RU486	ru486	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	finding	finding	NN	NN	_	9	nsubj	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	Vpr	vpr	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	regulate	regulate	VB	VB	_	2	ccomp	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	6	dobj	_	_
9	supports	support	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	hypothesis	hypothesis	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	20	mark	_	_
13	some	some	DT	DT	_	14	det	_	_
14	aspects	aspect	NNS	NNS	_	20	nsubj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	pathogenesis	pathogenesis	NN	NN	_	14	nmod	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	the	the	DT	DT	_	20	det	_	_
20	consequence	consequence	NN	NN	_	11	ccomp	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	dysregulation	dysregulation	NN	NN	_	20	nmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	Vpr	vpr	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Induction	induction	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	surface	surface	NN	NN	_	7	compound	_	_
6	adhesion	adhesion	NN	NN	_	7	compound	_	_
7	molecules	molecule	NNS	NNS	_	1	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	1	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	blocked	block	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	18	case	_	_
15	protein	protein	NN	NN	_	18	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
17	phosphatase	phosphatase	NN	NN	_	18	compound	_	_
18	inhibitors	inhibitor	NNS	NNS	_	13	nmod	_	_
19	:	:	:	:	_	13	punct	_	_
20	role	role	NN	NN	_	13	dep	_	_
21	of	of	IN	IN	_	27	case	_	_
22	the	the	DT	DT	_	27	det	_	_
23	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
24	transcription	transcription	NN	NN	_	27	compound	_	_
25	factor	factor	NN	NN	_	27	compound	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	7	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	laboratory	laboratory	NN	NN	_	2	nmod	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	indicated	indicate	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	phosphatase	phosphatase	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PTPase	ptpase	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	inhibitors	inhibitor	NNS	NNS	_	17	nsubj	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	down-modulate	down-modulate	VB	VB	_	7	ccomp	_	_
18	the	the	DT	DT	_	26	det	_	_
19	tumor	tumor	NN	NN	_	21	compound	_	_
20	necrosis	necrosis	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	TNF	tnf	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	-mediated	-mediated	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	17	dobj	_	_
27	of	of	IN	IN	_	33	case	_	_
28	the	the	DT	DT	_	33	det	_	_
29	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
30	transcription	transcription	NN	NN	_	33	compound	_	_
31	factor	factor	NN	NN	_	33	compound	_	_
32	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	26	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	ML-1a	ml-1a	NN	NN	_	26	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	a	a	DT	DT	_	40	det	_	_
38	monocytic	monocytic	JJ	JJ	_	40	amod	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	line	line	NN	NN	_	35	appos	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	Singh	Singh	NNP	NNP	_	7	dep	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	Aggarwal	Aggarwal	NNP	NNP	_	42	conj	_	_
45	,	,	,	,	_	42	punct	_	_
46	J.	J.	NNP	NNP	_	48	compound	_	_
47	Biol.	Biol.	NNP	NNP	_	48	compound	_	_
48	Chem.	Chem.	NNP	NNP	_	42	appos	_	_
49	1995	1995	CD	CD	_	48	nummod	_	_
50	:	:	:	:	_	42	punct	_	_
51	270	270	CD	CD	_	42	dep	_	_
52	:	:	:	:	_	42	punct	_	_
53	10631	10631	CD	CD	_	42	dep	_	_
54	)	)	-RRB-	-RRB-	_	42	punct	_	_
55	.	.	.	.	_	7	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	TNF	tnf	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	one	one	CD	CD	_	31	advcl	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	major	major	JJ	JJ	_	8	amod	_	_
8	inducers	inducer	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	various	various	JJ	JJ	_	12	amod	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	endothelial	endothelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	expression	expression	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	known	know	VBN	VBN	_	4	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	require	require	VB	VB	_	21	xcomp	_	_
24	the	the	DT	DT	_	25	det	_	_
25	activation	activation	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
28	B	b	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	31	punct	_	_
30	we	we	PRP	PRP	_	31	nsubj	_	_
31	examined	examine	VBD	VBD	_	0	root	_	_
32	the	the	DT	DT	_	33	det	_	_
33	effect	effect	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	PTPase	ptpase	NN	NN	_	36	compound	_	_
36	inhibitors	inhibitor	NNS	NNS	_	33	nmod	_	_
37	on	on	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	TNF-mediated	tnf-mediated	JJ	JJ	_	40	amod	_	_
40	induction	induction	NN	NN	_	33	nmod	_	_
41	of	of	IN	IN	_	46	case	_	_
42	intracellular	intracellular	JJ	JJ	_	46	amod	_	_
43	adhesion	adhesion	NN	NN	_	46	compound	_	_
44	molecule	molecule	NN	NN	_	46	compound	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	ICAM	icam	NN	NN	_	40	nmod	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	-1	-1	CD	CD	_	46	nummod	_	_
49	,	,	,	,	_	46	punct	_	_
50	vascular	vascular	JJ	JJ	_	55	amod	_	_
51	cell	cell	NN	NN	_	55	compound	_	_
52	adhesion	adhesion	NN	NN	_	55	compound	_	_
53	molecule	molecule	NN	NN	_	55	compound	_	_
54	(	(	-LRB-	-LRB-	_	55	punct	_	_
55	VCAM	vcam	NN	NN	_	46	conj	_	_
56	)	)	-RRB-	-RRB-	_	55	punct	_	_
57	-1	-1	CD	CD	_	55	nummod	_	_
58	and	and	CC	CC	_	46	cc	_	_
59	endothelial	endothelial	JJ	JJ	_	64	amod	_	_
60	leukocyte	leukocyte	NN	NN	_	64	compound	_	_
61	adhesion	adhesion	NN	NN	_	64	compound	_	_
62	molecule	molecule	NN	NN	_	64	compound	_	_
63	(	(	-LRB-	-LRB-	_	64	punct	_	_
64	ELAM	elam	NN	NN	_	46	conj	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	-1	-1	CD	CD	_	64	nummod	_	_
67	.	.	.	.	_	31	punct	_	_

1	Like	like	IN	IN	_	2	case	_	_
2	ML-1a	ml-1a	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	dermal	dermal	JJ	JJ	_	8	amod	_	_
6	microvessel	microvessel	NN	NN	_	8	compound	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	16	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MVEC	mvec	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	treated	treat	VBN	VBN	_	8	acl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	TNF	tnf	NN	NN	_	12	nmod	_	_
15	rapidly	rapidly	RB	RB	_	16	advmod	_	_
16	activated	activate	VBD	VBD	_	0	root	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	within	within	IN	IN	_	20	case	_	_
19	30	30	CD	CD	_	20	nummod	_	_
20	min	min	NN	NN	_	16	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	16	dobj	_	_
24	;	;	:	:	_	16	punct	_	_
25	this	this	DT	DT	_	26	det	_	_
26	effect	effect	NN	NN	_	29	nsubjpass	_	_
27	was	be	VBD	VBD	_	29	auxpass	_	_
28	completely	completely	RB	RB	_	29	advmod	_	_
29	abolished	abolish	VBN	VBN	_	16	parataxis	_	_
30	by	by	IN	IN	_	31	case	_	_
31	co-treatment	co-treatment	NN	NN	_	29	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	phenylarsine	phenylarsine	NN	NN	_	34	compound	_	_
34	oxide	oxide	NN	NN	_	31	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	PAO	pao	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	,	,	,	,	_	34	punct	_	_
39	a	a	DT	DT	_	41	det	_	_
40	specific	specific	JJ	JJ	_	41	amod	_	_
41	inhibitor	inhibitor	NN	NN	_	34	appos	_	_
42	of	of	IN	IN	_	43	case	_	_
43	PTPase	ptpase	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ICAM-1	icam-1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	VCAM-1	vcam-1	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	ELAM-1	elam-1	NN	NN	_	4	conj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	TNF	tnf	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	MVEC	mvec	NNS	NNS	_	2	nmod	_	_
14	occurred	occur	VBD	VBD	_	0	root	_	_
15	within	within	IN	IN	_	17	case	_	_
16	6	6	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	was	be	VBD	VBD	_	22	auxpass	_	_
20	also	also	RB	RB	_	22	advmod	_	_
21	completely	completely	RB	RB	_	22	advmod	_	_
22	down-regulated	down-regulate	VBN	VBN	_	14	conj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	PAO	pao	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	dose-dependent	dose-dependent	JJ	JJ	_	28	amod	_	_
28	manner	manner	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	PAO	pao	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	effective	effective	JJ	JJ	_	3	xcomp	_	_
7	even	even	RB	RB	_	8	advmod	_	_
8	when	when	WRB	WRB	_	9	advmod	_	_
9	added	add	VBN	VBN	_	3	advcl	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	9	nmod	_	_
12	after	after	IN	IN	_	11	case	_	_
13	TNF	tnf	NN	NN	_	11	dep	_	_
14	,	,	,	,	_	3	punct	_	_
15	suggesting	suggest	VBG	VBG	_	3	xcomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	rapid	rapid	JJ	JJ	_	18	amod	_	_
18	mode	mode	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	action	action	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	inhibitor	inhibitor	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Besides	besides	IN	IN	_	2	case	_	_
2	PAO	pao	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	inhibitors	inhibitor	NNS	NNS	_	15	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PTPase	ptpase	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	including	include	VBG	VBG	_	10	case	_	_
10	pervanadate	pervanadate	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	diamide	diamide	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	blocked	block	VBD	VBD	_	0	root	_	_
16	TNF-dependent	tnf-dependent	JJ	JJ	_	19	amod	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	15	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	induction	induction	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	all	all	PDT	PDT	_	27	dep	_	_
24	the	the	DT	DT	_	27	det	_	_
25	three	three	CD	CD	_	27	nummod	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	Consistent	consistent	JJ	JJ	_	14	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	attachment	attachment	NN	NN	_	14	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	MVEC	mvec	NNS	NNS	_	7	nmod	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	blocked	block	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	PTPase	ptpase	NN	NN	_	18	compound	_	_
18	inhibitors	inhibitor	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	overall	overall	RB	RB	_	7	advmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	results	result	NNS	NNS	_	7	nsubj	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	a	a	DT	DT	_	10	det	_	_
10	PTPase	ptpase	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	7	ccomp	_	_
13	either	either	CC	CC	_	15	cc:preconj	_	_
14	directly	directly	RB	RB	_	15	advmod	_	_
15	or	or	CC	CC	_	12	advmod	_	_
16	indirectly	indirectly	RB	RB	_	15	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	pathway	pathway	NN	NN	_	12	nmod	_	_
20	leading	lead	VBG	VBG	_	19	acl	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	induction	induction	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	adhesion	adhesion	NN	NN	_	28	compound	_	_
28	molecules	molecule	NNS	NNS	_	23	nmod	_	_
29	by	by	IN	IN	_	30	case	_	_
30	TNF	tnf	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Because	because	IN	IN	_	4	case	_	_
2	of	of	IN	IN	_	4	case	_	_
3	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
4	role	role	NN	NN	_	11	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	adhesion	adhesion	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	PTPase	ptpase	NN	NN	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	provide	provide	VB	VB	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	novel	novel	JJ	JJ	_	14	amod	_	_
14	target	target	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	drug	drug	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	for	for	IN	IN	_	19	case	_	_
19	treatment	treatment	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	inflammation	inflammation	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	atherogenesis	atherogenesis	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	tumor	tumor	NN	NN	_	27	compound	_	_
27	metastasis	metastasis	NN	NN	_	21	conj	_	_
28	.	.	.	.	_	11	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	the	the	DT	DT	_	9	det	_	_
5	vascular	vascular	JJ	JJ	_	9	amod	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	adhesion	adhesion	NN	NN	_	9	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
13	expressing	express	VBG	VBG	_	12	acl	_	_
14	human	human	JJ	JJ	_	21	amod	_	_
15	T-cell	t-cell	NN	NN	_	21	compound	_	_
16	leukemia	leukemia	NN	NN	_	21	compound	_	_
17	virus	virus	NN	NN	_	21	compound	_	_
18	type	type	NN	NN	_	21	compound	_	_
19	1	1	CD	CD	_	21	nummod	_	_
20	Tax	tax	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	13	dobj	_	_
22	.	.	.	.	_	2	punct	_	_

1	Recruitment	recruitment	NN	NN	_	12	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	extravasation	extravasation	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	through	through	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	blood-brain	blood-brain	JJ	JJ	_	10	amod	_	_
10	barrier	barrier	NN	NN	_	1	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	favored	favor	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	adhesion	adhesion	NN	NN	_	16	compound	_	_
15	molecule-mediated	molecule-mediated	JJ	JJ	_	16	amod	_	_
16	interactions	interaction	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	circulating	circulate	VBG	VBG	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Since	since	IN	IN	_	20	mark	_	_
2	a	a	DT	DT	_	5	det	_	_
3	common	common	JJ	JJ	_	5	amod	_	_
4	pathological	pathological	JJ	JJ	_	3	dep	_	_
5	finding	finding	NN	NN	_	20	nsubj	_	_
6	in	in	IN	IN	_	17	case	_	_
7	human	human	JJ	JJ	_	17	amod	_	_
8	T-cell	t-cell	NN	NN	_	17	compound	_	_
9	leukemia	leukemia	NN	NN	_	17	compound	_	_
10	virus	virus	NN	NN	_	17	compound	_	_
11	type	type	NN	NN	_	17	compound	_	_
12	1	1	CD	CD	_	17	nummod	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	HTLV-1	htlv-1	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	-associated	-associated	JJ	JJ	_	17	amod	_	_
17	diseases	disease	NNS	NNS	_	5	nmod	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	the	the	DT	DT	_	20	det	_	_
20	infiltration	infiltration	NN	NN	_	31	advcl	_	_
21	of	of	IN	IN	_	24	case	_	_
22	HTLV-1-infected	htlv-1-infected	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
25	into	into	IN	IN	_	27	case	_	_
26	various	various	JJ	JJ	_	27	amod	_	_
27	organs	organ	NNS	NNS	_	20	nmod	_	_
28	,	,	,	,	_	31	punct	_	_
29	we	we	PRP	PRP	_	31	nsubj	_	_
30	have	have	VBP	VBP	_	31	aux	_	_
31	looked	look	VBN	VBN	_	0	root	_	_
32	for	for	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	profile	profile	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	adhesion	adhesion	NN	NN	_	37	compound	_	_
37	molecules	molecule	NNS	NNS	_	34	nmod	_	_
38	expressed	express	VBN	VBN	_	37	acl	_	_
39	by	by	IN	IN	_	42	case	_	_
40	HTLV-1-transformed	htlv-1-transformed	JJ	JJ	_	42	amod	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	31	punct	_	_

1	Flow	flow	NN	NN	_	3	compound	_	_
2	cytometry	cytometry	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	aux	_	_
9	expressing	express	VBG	VBG	_	4	ccomp	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	vascular	vascular	JJ	JJ	_	16	amod	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	adhesion	adhesion	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	11	nmod	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	VCAM-1	vcam-1	NN	NN	_	16	appos	_	_
20	-LSB-	-lsb-	-LRB-	-LRB-	_	21	punct	_	_
21	CD106	cd106	NN	NN	_	19	appos	_	_
22	-RSB-	-rsb-	-RRB-	-RRB-	_	21	punct	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	,	,	,	,	_	16	punct	_	_
25	a	a	DT	DT	_	27	det	_	_
26	110-kDa	110-kda	JJ	JJ	_	27	amod	_	_
27	member	member	NN	NN	_	16	appos	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	immunoglobulin	immunoglobulin	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	superfamily	superfamily	NN	NN	_	27	nmod	_	_
33	,	,	,	,	_	27	punct	_	_
34	first	first	RB	RB	_	35	advmod	_	_
35	identified	identify	VBN	VBN	_	27	acl	_	_
36	on	on	IN	IN	_	38	case	_	_
37	endothelial	endothelial	JJ	JJ	_	38	amod	_	_
38	cells	cell	NNS	NNS	_	35	nmod	_	_
39	stimulated	stimulate	VBN	VBN	_	38	acl	_	_
40	with	with	IN	IN	_	42	case	_	_
41	inflammatory	inflammatory	JJ	JJ	_	42	amod	_	_
42	cytokines	cytokine	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	adhesion	adhesion	NN	NN	_	3	compound	_	_
3	molecule	molecule	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	obtained	obtain	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	13	case	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	patient	patient	NN	NN	_	10	nmod	_	_
14	with	with	IN	IN	_	18	case	_	_
15	HTLV-1-associated	htlv-1-associated	JJ	JJ	_	18	amod	_	_
16	myelopathy/tropical	myelopathy/tropical	JJ	JJ	_	18	amod	_	_
17	spastic	spastic	JJ	JJ	_	18	amod	_	_
18	paraparesis	paraparesis	NN	NN	_	13	nmod	_	_
19	but	but	CC	CC	_	9	cc	_	_
20	not	not	RB	RB	_	24	neg	_	_
21	by	by	IN	IN	_	24	case	_	_
22	activated	activate	VBN	VBN	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	9	conj	_	_
25	isolated	isolate	VBN	VBN	_	24	acl	_	_
26	from	from	IN	IN	_	30	case	_	_
27	one	one	CD	CD	_	30	nummod	_	_
28	normal	normal	JJ	JJ	_	30	amod	_	_
29	blood	blood	NN	NN	_	30	compound	_	_
30	donor	donor	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	viral	viral	JJ	JJ	_	8	amod	_	_
6	trans-activator	trans-activator	NN	NN	_	8	compound	_	_
7	Tax	tax	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	2	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	VCAM-1	vcam-1	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	first	first	RB	RB	_	16	advmod	_	_
16	indicated	indicate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	detection	detection	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	this	this	DT	DT	_	23	det	_	_
22	adhesion	adhesion	NN	NN	_	23	compound	_	_
23	molecule	molecule	NN	NN	_	19	nmod	_	_
24	on	on	IN	IN	_	27	case	_	_
25	Jurkat	jurkat	NN	NN	_	27	compound	_	_
26	T-cell	t-cell	NN	NN	_	27	compound	_	_
27	clones	clone	NNS	NNS	_	19	nmod	_	_
28	stably	stably	RB	RB	_	29	advmod	_	_
29	expressing	express	VBG	VBG	_	27	acl	_	_
30	the	the	DT	DT	_	32	det	_	_
31	tax	tax	NN	NN	_	32	compound	_	_
32	gene	gene	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Tax	tax	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	VCAM-1	vcam-1	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	2	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	next	next	RB	RB	_	11	advmod	_	_
11	confirmed	confirm	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	JPX-9	jpx-9	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	a	a	DT	DT	_	17	det	_	_
17	subclone	subclone	NN	NN	_	14	appos	_	_
18	of	of	IN	IN	_	20	case	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	carrying	carry	VBG	VBG	_	14	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	tax	tax	NN	NN	_	25	compound	_	_
25	sequences	sequence	NNS	NNS	_	22	dobj	_	_
26	under	under	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	control	control	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	an	a	DT	DT	_	32	det	_	_
31	inducible	inducible	JJ	JJ	_	32	amod	_	_
32	promoter	promoter	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	deletion	deletion	NN	NN	_	16	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	mutation	mutation	NN	NN	_	3	conj	_	_
6	analyses	analysis	NNS	NNS	_	3	dep	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	VCAM-1	vcam-1	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	3	nmod	_	_
11	performed	perform	VBN	VBN	_	3	acl	_	_
12	with	with	IN	IN	_	15	case	_	_
13	chloramphenicol	chloramphenicol	NN	NN	_	15	compound	_	_
14	acetyltransferase	acetyltransferase	NN	NN	_	15	compound	_	_
15	constructs	construct	NNS	NNS	_	11	nmod	_	_
16	revealed	reveal	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	Tax	tax	NN	NN	_	21	nsubj	_	_
19	was	be	VBD	VBD	_	21	aux	_	_
20	trans	trans	JJ	JJ	_	21	dep	_	_
21	activating	activate	VBG	VBG	_	16	ccomp	_	_
22	the	the	DT	DT	_	24	det	_	_
23	VCAM-1	vcam-1	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	21	dobj	_	_
25	via	via	IN	IN	_	28	case	_	_
26	two	two	CD	CD	_	28	nummod	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	21	nmod	_	_
29	present	present	JJ	JJ	_	28	amod	_	_
30	at	at	IN	IN	_	31	case	_	_
31	bp	bp	NN	NN	_	29	nmod	_	_
32	-72	-72	CD	CD	_	31	dep	_	_
33	and	and	CC	CC	_	31	cc	_	_
34	-57	-57	CD	CD	_	31	conj	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	VCAM-1	vcam-1	NN	NN	_	39	compound	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	promoter	promoter	NN	NN	_	29	nmod	_	_
40	,	,	,	,	_	21	punct	_	_
41	with	with	IN	IN	_	46	mark	_	_
42	both	both	DT	DT	_	46	nsubjpass	_	_
43	of	of	IN	IN	_	44	case	_	_
44	them	they	PRP	PRP	_	42	nmod	_	_
45	being	be	VBG	VBG	_	46	auxpass	_	_
46	required	require	VBN	VBN	_	21	advcl	_	_
47	for	for	IN	IN	_	50	case	_	_
48	the	the	DT	DT	_	50	det	_	_
49	Tax-induced	tax-induced	JJ	JJ	_	50	amod	_	_
50	expression	expression	NN	NN	_	46	nmod	_	_
51	of	of	IN	IN	_	54	case	_	_
52	this	this	DT	DT	_	54	det	_	_
53	adhesion	adhesion	NN	NN	_	54	compound	_	_
54	molecule	molecule	NN	NN	_	50	nmod	_	_
55	.	.	.	.	_	16	punct	_	_

1	Finally	finally	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	gel	gel	NN	NN	_	6	compound	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	proteins	protein	NNS	NNS	_	10	nmod	_	_
13	specifically	specifically	RB	RB	_	14	advmod	_	_
14	bound	bind	VBN	VBN	_	12	acl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	these	these	DT	DT	_	19	det	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	motifs	motif	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	7	punct	_	_
21	confirming	confirm	VBG	VBG	_	7	advcl	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	VCAM-1	vcam-1	NN	NN	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	induced	induce	VBN	VBN	_	21	ccomp	_	_
26	on	on	IN	IN	_	28	case	_	_
27	Tax-expressing	tax-expressing	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	kappaB-dependent	kappab-dependent	JJ	JJ	_	32	amod	_	_
32	manner	manner	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Collectively	collectively	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	6	nsubj	_	_
5	therefore	therefore	RB	RB	_	6	advmod	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	exclusive	exclusive	JJ	JJ	_	11	amod	_	_
10	Tax-induced	tax-induced	JJ	JJ	_	9	dep	_	_
11	expression	expression	NN	NN	_	18	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	VCAM-1	vcam-1	NN	NN	_	11	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	represent	represent	VB	VB	_	6	ccomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	pivotal	pivotal	JJ	JJ	_	21	amod	_	_
21	event	event	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	progression	progression	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	HTLV-1-associated	htlv-1-associated	JJ	JJ	_	27	amod	_	_
27	diseases	disease	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Blockade	blockade	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T-cell	t-cell	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	dithiocarbamates	dithiocarbamate	NNS	NNS	_	1	nmod	_	_
7	involves	involve	VBZ	VBZ	_	0	root	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	inhibition	inhibition	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	18	case	_	_
13	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
14	factor	factor	NN	NN	_	18	compound	_	_
15	of	of	IN	IN	_	18	amod	_	_
16	activated	activate	VBN	VBN	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Dithiocarbamates	dithiocarbamate	NNS	NNS	_	8	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	DTCs	dtc	NNS	NNS	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	have	have	VBP	VBP	_	8	aux	_	_
6	recently	recently	RB	RB	_	8	advmod	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	reported	report	VBN	VBN	_	0	root	_	_
9	as	as	IN	IN	_	11	case	_	_
10	powerful	powerful	JJ	JJ	_	11	amod	_	_
11	inhibitors	inhibitor	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	number	number	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Given	given	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	role	role	NN	NN	_	23	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	10	nmod	_	_
18	,	,	,	,	_	23	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	inhibitors	inhibitor	NNS	NNS	_	23	nsubjpass	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	suggested	suggest	VBN	VBN	_	0	root	_	_
24	as	as	IN	IN	_	27	case	_	_
25	potential	potential	JJ	JJ	_	27	amod	_	_
26	therapeutic	therapeutic	JJ	JJ	_	25	dep	_	_
27	drugs	drug	NNS	NNS	_	23	nmod	_	_
28	for	for	IN	IN	_	30	case	_	_
29	inflammatory	inflammatory	JJ	JJ	_	30	amod	_	_
30	diseases	disease	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	DTCs	dtc	NNS	NNS	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	2	ccomp	_	_
7	both	both	CC	CC	_	13	cc:preconj	_	_
8	interleukin	interleukin	NN	NN	_	13	compound	_	_
9	2	2	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-2	il-2	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	synthesis	synthesis	NN	NN	_	6	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	membrane	membrane	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	antigens	antigen	NNS	NNS	_	16	nmod	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	induced	induce	VBN	VBN	_	18	acl:relcl	_	_
22	during	during	IN	IN	_	24	case	_	_
23	T-cell	t-cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	18	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	occurred	occur	VBD	VBD	_	2	acl:relcl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	parallel	parallel	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-Jun	c-jun	NN	NN	_	9	nmod	_	_
12	transactivating	transactivating	NN	NN	_	13	compound	_	_
13	functions	function	NNS	NNS	_	11	dep	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	expression	expression	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	reflected	reflect	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	21	case	_	_
20	transfection	transfection	NN	NN	_	21	compound	_	_
21	experiments	experiment	NNS	NNS	_	18	nmod	_	_
22	at	at	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	IL-2	il-2	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	level	level	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	involved	involve	VBD	VBD	_	18	conj	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	only	only	RB	RB	_	33	cc:preconj	_	_
32	the	the	DT	DT	_	33	det	_	_
33	inhibition	inhibition	NN	NN	_	29	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	NF-kappaB-driven	nf-kappab-driven	JJ	JJ	_	37	amod	_	_
36	reporter	reporter	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	33	nmod	_	_
38	but	but	CC	CC	_	33	cc	_	_
39	also	also	RB	RB	_	40	advmod	_	_
40	that	that	DT	DT	_	33	conj	_	_
41	of	of	IN	IN	_	47	case	_	_
42	nuclear	nuclear	JJ	JJ	_	47	amod	_	_
43	factor	factor	NN	NN	_	47	compound	_	_
44	of	of	IN	IN	_	47	amod	_	_
45	activated	activate	VBN	VBN	_	47	amod	_	_
46	T	t	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	40	nmod	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	NFAT	nfat	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	.	.	.	.	_	18	punct	_	_

1	Accordingly	accordingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EMSAs	emsa	NNS	NNS	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	17	mark	_	_
12	pyrrolidine	pyrrolidine	NN	NN	_	13	compound	_	_
13	DTC	dtc	NN	NN	_	17	nsubj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PDTC	pdtc	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	prevented	prevent	VBD	VBD	_	10	ccomp	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	NFAT	nfat	NN	NN	_	22	compound	_	_
22	DNA-binding	dna-binding	NN	NN	_	18	conj	_	_
23	activity	activity	NN	NN	_	18	dep	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	17	nmod	_	_
27	stimulated	stimulate	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	32	case	_	_
29	either	either	CC	CC	_	32	cc:preconj	_	_
30	phorbol	phorbol	NN	NN	_	32	compound	_	_
31	myristate	myristate	NN	NN	_	32	compound	_	_
32	acetate	acetate	NN	NN	_	27	nmod	_	_
33	plus	plus	CC	CC	_	32	cc	_	_
34	ionophore	ionophore	NN	NN	_	32	conj	_	_
35	or	or	CC	CC	_	32	cc	_	_
36	antibodies	antibody	NNS	NNS	_	32	conj	_	_
37	against	against	IN	IN	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	CD3-T-cell	cd3-t-cell	NN	NN	_	41	compound	_	_
40	receptor	receptor	NN	NN	_	41	compound	_	_
41	complex	complex	NN	NN	_	36	nmod	_	_
42	and	and	CC	CC	_	17	cc	_	_
43	simultaneously	simultaneously	RB	RB	_	44	advmod	_	_
44	activated	activate	VBD	VBD	_	17	conj	_	_
45	the	the	DT	DT	_	46	det	_	_
46	binding	binding	NN	NN	_	44	dobj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	AP-1	ap-1	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PDTC	pdtc	NN	NN	_	5	nsubj	_	_
4	differentially	differentially	RB	RB	_	5	advmod	_	_
5	targeted	target	VBD	VBD	_	0	root	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	NFATp	nfatp	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NFATc	nfatc	NN	NN	_	7	conj	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	7	dep	_	_
12	,	,	,	,	_	5	punct	_	_
13	inhibiting	inhibit	VBG	VBG	_	5	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transactivation	transactivation	NN	NN	_	16	compound	_	_
16	functions	function	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NFATp	nfatp	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	mRNA	mrna	NN	NN	_	21	compound	_	_
21	induction	induction	NN	NN	_	16	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NFATc	nfatc	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Strikingly	strikingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Western	western	NN	NN	_	4	compound	_	_
4	blotting	blotting	NN	NN	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	immunocytochemical	immunocytochemical	JJ	JJ	_	4	conj	_	_
7	experiments	experiment	NNS	NNS	_	4	dep	_	_
8	indicated	indicate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	PDTC	pdtc	NN	NN	_	11	nsubj	_	_
11	promoted	promote	VBD	VBD	_	8	ccomp	_	_
12	a	a	DT	DT	_	16	det	_	_
13	transient	transient	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	rapid	rapid	JJ	JJ	_	13	conj	_	_
16	shuttling	shuttling	NN	NN	_	11	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NFATp	nfatp	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NFATc	nfatc	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	11	punct	_	_
22	leading	lead	VBG	VBG	_	11	advcl	_	_
23	to	to	TO	TO	_	26	case	_	_
24	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
25	accelerated	accelerate	VBN	VBN	_	26	amod	_	_
26	export	export	NN	NN	_	22	nmod	_	_
27	from	from	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	nucleus	nucleus	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	activated	activate	VBN	VBN	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	NFAT	nfat	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	PDTC	pdtc	NN	NN	_	5	nmod	_	_
12	could	could	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
15	for	for	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	rapid	rapid	JJ	JJ	_	18	amod	_	_
18	shuttling	shuttling	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	NFAT	nfat	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	14	punct	_	_
23	therefore	therefore	RB	RB	_	25	advmod	_	_
24	transiently	transiently	RB	RB	_	25	advmod	_	_
25	converting	convert	VBG	VBG	_	14	advcl	_	_
26	the	the	DT	DT	_	28	det	_	_
27	sustained	sustained	JJ	JJ	_	28	amod	_	_
28	transactivation	transactivation	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	this	this	DT	DT	_	32	det	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factor	factor	NN	NN	_	28	nmod	_	_
33	that	that	WDT	WDT	_	34	nsubj	_	_
34	occurs	occur	VBZ	VBZ	_	28	acl:relcl	_	_
35	during	during	IN	IN	_	37	case	_	_
36	lymphocyte	lymphocyte	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	2	punct	_	_
39	and	and	CC	CC	_	2	cc	_	_
40	show	show	VBP	VBP	_	2	conj	_	_
41	that	that	IN	IN	_	49	mark	_	_
42	c-Jun	c-jun	NN	NN	_	44	compound	_	_
43	NH2-terminal	nh2-terminal	JJ	JJ	_	44	amod	_	_
44	kinase	kinase	NN	NN	_	49	nsubj	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	JNK	jnk	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	can	can	MD	MD	_	49	aux	_	_
49	act	act	VB	VB	_	40	ccomp	_	_
50	by	by	IN	IN	_	52	mark	_	_
51	directly	directly	RB	RB	_	52	advmod	_	_
52	phosphorylating	phosphorylate	VBG	VBG	_	49	advcl	_	_
53	NFATp	nfatp	NN	NN	_	52	dobj	_	_
54	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	combined	combined	JJ	JJ	_	7	amod	_	_
6	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	12	nsubj	_	_
8	on	on	IN	IN	_	9	case	_	_
9	NFAT	nfat	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-KB	nf-kb	NN	NN	_	9	conj	_	_
12	support	support	VBP	VBP	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	potential	potential	JJ	JJ	_	15	amod	_	_
15	use	use	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	DTCs	dtc	NNS	NNS	_	15	nmod	_	_
18	as	as	IN	IN	_	19	case	_	_
19	immunosuppressants	immunosuppressant	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
4	factor	factor	NN	NN	_	6	compound	_	_
5	kappa	kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	1	cc	_	_
8	CD18-mediated	cd18-mediated	JJ	JJ	_	10	amod	_	_
9	leukocyte	leukocyte	NN	NN	_	10	compound	_	_
10	adhesion	adhesion	NN	NN	_	1	conj	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	corneal	corneal	NN	NN	_	14	compound	_	_
14	endothelium	endothelium	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	PURPOSE	purpose	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	demonstrate	demonstrate	VB	VB	_	1	dep	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	leukocyte	leukocyte	NN	NN	_	7	compound	_	_
7	adhesion	adhesion	NN	NN	_	14	nsubjpass	_	_
8	to	to	TO	TO	_	12	case	_	_
9	cultured	culture	VBN	VBN	_	12	amod	_	_
10	corneal	corneal	NN	NN	_	12	compound	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	4	ccomp	_	_
15	by	by	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CD18	cd18	NN	NN	_	18	compound	_	_
18	antigen	antigen	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	determine	determine	VB	VB	_	4	conj	_	_
23	whether	whether	IN	IN	_	26	mark	_	_
24	dexamethasone	dexamethasone	NN	NN	_	26	nsubj	_	_
25	directly	directly	RB	RB	_	26	advmod	_	_
26	suppresses	suppress	VBZ	VBZ	_	22	ccomp	_	_
27	adhesion	adhesion	NN	NN	_	26	dobj	_	_
28	by	by	IN	IN	_	29	mark	_	_
29	inhibiting	inhibit	VBG	VBG	_	26	advcl	_	_
30	activation	activation	NN	NN	_	29	dobj	_	_
31	of	of	IN	IN	_	35	case	_	_
32	nuclear	nuclear	JJ	JJ	_	35	amod	_	_
33	factor	factor	NN	NN	_	35	compound	_	_
34	kappa	kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	30	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	NFkappaB	nfkappab	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	4	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Cultured	culture	VBN	VBN	_	6	amod	_	_
4	bovine	bovine	JJ	JJ	_	6	amod	_	_
5	corneal	corneal	NN	NN	_	6	compound	_	_
6	endothelium	endothelium	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	stimulated	stimulate	VBN	VBN	_	1	dep	_	_
9	for	for	IN	IN	_	11	case	_	_
10	6	6	CD	CD	_	11	nummod	_	_
11	hours	hour	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	18	case	_	_
13	40	40	CD	CD	_	14	compound	_	_
14	micron/ml	micron/ml	NN	NN	_	18	amod	_	_
15	tumor	tumor	NN	NN	_	18	compound	_	_
16	necrosis	necrosis	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	8	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TNFalpha	tnfalpha	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	1	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	added	add	VBN	VBN	_	0	root	_	_
4	1	1	CD	CD	_	5	nummod	_	_
5	hour	hour	NN	NN	_	3	nmod	_	_
6	before	before	IN	IN	_	5	case	_	_
7	TNFalpha	tnfalpha	NN	NN	_	8	compound	_	_
8	stimulation	stimulation	NN	NN	_	5	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	dexamethasone	dexamethasone	NN	NN	_	12	compound	_	_
12	group	group	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	neutrophils	neutrophil	NNS	NNS	_	12	nsubjpass	_	_
5	separated	separate	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	healthy	healthy	JJ	JJ	_	10	amod	_	_
9	human	human	JJ	JJ	_	8	dep	_	_
10	volunteer	volunteer	NN	NN	_	5	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	added	add	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	17	nmod	_	_
14	or	or	CC	CC	_	17	cc	_	_
15	without	without	IN	IN	_	17	conj	_	_
16	anti-CD18	anti-cd18	JJ	JJ	_	17	amod	_	_
17	antibody	antibody	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	culture	culture	NN	NN	_	3	compound	_	_
3	plate	plate	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	settled	settle	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	15	15	CD	CD	_	8	nummod	_	_
8	minutes	minute	NNS	NNS	_	5	nmod	_	_
9	at	at	IN	IN	_	12	case	_	_
10	37	37	CD	CD	_	12	nummod	_	_
11	degrees	degree	NNS	NNS	_	12	compound	_	_
12	C	c	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	then	then	RB	RB	_	18	advmod	_	_
16	neutrophils	neutrophil	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	5	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	N-formyl-methionyl-leucyl-phenylalanine	n-formyl-methionyl-leucyl-phenylalanine	NN	NN	_	18	nmod	_	_
21	for	for	IN	IN	_	23	case	_	_
22	5	5	CD	CD	_	23	nummod	_	_
23	minutes	minute	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Nonadherent	nonadherent	JJ	JJ	_	2	amod	_	_
2	neutrophils	neutrophil	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	removed	remove	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	sealing	seal	VBG	VBG	_	4	advcl	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	inverting	invert	VBG	VBG	_	6	conj	_	_
9	the	the	DT	DT	_	10	det	_	_
10	culture	culture	NN	NN	_	6	dobj	_	_
11	well	well	RB	RB	_	6	advmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	intracellular	intracellular	JJ	JJ	_	3	amod	_	_
3	localization	localization	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NFkappaB	nfkappab	NN	NN	_	3	nmod	_	_
6	after	after	IN	IN	_	8	case	_	_
7	TNFalpha	tnfalpha	NN	NN	_	8	compound	_	_
8	simulation	simulation	NN	NN	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	determined	determine	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	confocal	confocal	JJ	JJ	_	13	amod	_	_
13	immunocytochemistry	immunocytochemistry	NN	NN	_	10	nmod	_	_
14	using	use	VBG	VBG	_	13	acl	_	_
15	an	a	DT	DT	_	17	det	_	_
16	anti-p65	anti-p65	JJ	JJ	_	17	amod	_	_
17	antibody	antibody	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	10	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Neutrophil	neutrophil	NN	NN	_	4	compound	_	_
4	adhesion	adhesion	NN	NN	_	10	nsubj	_	_
5	to	to	TO	TO	_	9	case	_	_
6	cultured	culture	VBN	VBN	_	9	amod	_	_
7	corneal	corneal	NN	NN	_	9	compound	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	increased	increase	VBD	VBD	_	1	dep	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	on	on	IN	IN	_	13	case	_	_
13	exposure	exposure	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	TNFalpha	tnfalpha	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	451.4+/-45.4	451.4+/-45.4	CD	CD	_	18	nummod	_	_
18	cells/mm2	cells/mm2	NNS	NNS	_	10	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	n	n	NN	NN	_	18	appos	_	_
21	=	=	JJ	JJ	_	20	amod	_	_
22	16	16	CD	CD	_	21	dep	_	_
23	)	)	-RRB-	-RRB-	_	18	punct	_	_
24	compared	compare	VBN	VBN	_	26	case	_	_
25	to	to	TO	TO	_	26	case	_	_
26	control	control	NN	NN	_	10	advcl	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	156.7+/-27.3	156.7+/-27.3	CD	CD	_	29	nummod	_	_
29	cells/mm2	cells/mm2	NNS	NNS	_	26	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	n	n	NN	NN	_	29	appos	_	_
32	=	=	JJ	JJ	_	31	amod	_	_
33	16	16	CD	CD	_	32	dep	_	_
34	,	,	,	,	_	29	punct	_	_
35	P	p	NN	NN	_	29	appos	_	_
36	&lt;	&lt;	JJR	JJR	_	35	amod	_	_
37	0.01	0.01	CD	CD	_	36	dep	_	_
38	)	)	-RRB-	-RRB-	_	29	punct	_	_
39	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	adhesion	adhesion	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	suppressed	suppress	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	addition	addition	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	anti-CD18	anti-cd18	JJ	JJ	_	11	amod	_	_
11	antibody	antibody	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	157.6+/-25.1	157.6+/-25.1	CD	CD	_	14	nummod	_	_
14	cells/mm2	cells/mm2	NNS	NNS	_	11	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	n	n	NN	NN	_	14	appos	_	_
17	=	=	JJ	JJ	_	16	amod	_	_
18	8	8	CD	CD	_	17	dep	_	_
19	,	,	,	,	_	14	punct	_	_
20	P	p	NN	NN	_	14	appos	_	_
21	&lt;	&lt;	JJR	JJR	_	20	amod	_	_
22	0.01	0.01	CD	CD	_	21	dep	_	_
23	)	)	-RRB-	-RRB-	_	14	punct	_	_
24	and	and	CC	CC	_	8	cc	_	_
25	by	by	IN	IN	_	26	case	_	_
26	pretreatment	pretreatment	NN	NN	_	8	conj	_	_
27	with	with	IN	IN	_	30	case	_	_
28	10(-7)	10(-7)	CD	CD	_	29	compound	_	_
29	M	m	NN	NN	_	30	amod	_	_
30	dexamethasone	dexamethasone	NN	NN	_	26	nmod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	207.9+/-31.5	207.9+/-31.5	CD	CD	_	33	nummod	_	_
33	cells/mm2	cells/mm2	NNS	NNS	_	30	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	n	n	NN	NN	_	33	appos	_	_
36	=	=	JJ	JJ	_	35	amod	_	_
37	10	10	CD	CD	_	36	dep	_	_
38	,	,	,	,	_	33	punct	_	_
39	P	p	NN	NN	_	33	appos	_	_
40	&lt;	&lt;	JJR	JJR	_	39	amod	_	_
41	0.01	0.01	CD	CD	_	40	dep	_	_
42	)	)	-RRB-	-RRB-	_	33	punct	_	_
43	.	.	.	.	_	5	punct	_	_

1	Immunocytochemistry	immunocytochemistry	NN	NN	_	6	nsubj	_	_
2	60	60	CD	CD	_	3	nummod	_	_
3	minutes	minute	NNS	NNS	_	1	nmod	_	_
4	after	after	IN	IN	_	3	case	_	_
5	stimulation	stimulation	NN	NN	_	3	dep	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	NFkappaB	nfkappab	NN	NN	_	10	nsubj	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	located	located	JJ	JJ	_	6	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	unstimulated	unstimulated	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	;	;	:	:	_	6	punct	_	_
18	however	however	RB	RB	_	24	advmod	_	_
19	,	,	,	,	_	24	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	addition	addition	NN	NN	_	24	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	TNFalpha	tnfalpha	NN	NN	_	21	nmod	_	_
24	caused	cause	VBD	VBD	_	6	parataxis	_	_
25	NFkappaB	nfkappab	NN	NN	_	24	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	translocate	translocate	VB	VB	_	24	xcomp	_	_
28	into	into	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	4	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
4	tapered	taper	VBD	VBD	_	0	root	_	_
5	NFkappaB	nfkappab	NN	NN	_	6	compound	_	_
6	translocation	translocation	NN	NN	_	4	dobj	_	_
7	into	into	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Leukocyte	leukocyte	NN	NN	_	4	compound	_	_
4	adhesion	adhesion	NN	NN	_	10	nsubjpass	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	corneal	corneal	NN	NN	_	8	compound	_	_
8	endothelium	endothelium	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	1	dep	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	10	xcomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	CD18	cd18	NN	NN	_	13	nmod	_	_
16	expressed	express	VBN	VBN	_	15	acl	_	_
17	on	on	IN	IN	_	19	case	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	leukocytes	leukocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	endothelium	endothelium	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	dexamethasone	dexamethasone	NN	NN	_	1	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	leukocyte	leukocyte	NN	NN	_	9	compound	_	_
9	adhesion	adhesion	NN	NN	_	7	dobj	_	_
10	;	;	:	:	_	7	punct	_	_
11	this	this	DT	DT	_	14	nsubj	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	due	due	JJ	JJ	_	7	parataxis	_	_
15	in	in	IN	IN	_	16	case	_	_
16	part	part	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	suppression	suppression	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NFkappaB	nfkappab	NN	NN	_	22	compound	_	_
22	entry	entry	NN	NN	_	19	nmod	_	_
23	into	into	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	nucleus	nucleus	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Helenalin	helenalin	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	6	det	_	_
4	anti-inflammatory	anti-inflammatory	JJ	JJ	_	6	amod	_	_
5	sesquiterpene	sesquiterpene	NN	NN	_	6	compound	_	_
6	lactone	lactone	NN	NN	_	1	appos	_	_
7	from	from	IN	IN	_	8	case	_	_
8	Arnica	arnica	FW	FW	_	6	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	selectively	selectively	RB	RB	_	11	advmod	_	_
11	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	11	dobj	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	13	dep	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	16	punct	_	_
16	see	see	VB	VB	_	11	parataxis	_	_
17	comments	comment	NNS	NNS	_	16	dobj	_	_
18	-RSB-	-rsb-	-RRB-	-RRB-	_	16	punct	_	_

1	Alcoholic	alcoholic	JJ	JJ	_	2	amod	_	_
2	extracts	extract	NNS	NNS	_	23	nsubjpass	_	_
3	prepared	prepare	VBN	VBN	_	2	acl	_	_
4	form	form	IN	IN	_	6	case	_	_
5	Arnicae	arnicae	FW	FW	_	6	compound	_	_
6	flos	flos	FW	FW	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	collective	collective	JJ	JJ	_	10	amod	_	_
10	name	name	NN	NN	_	6	appos	_	_
11	for	for	IN	IN	_	12	case	_	_
12	flowerheads	flowerhead	NNS	NNS	_	10	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	Arnica	arnica	FW	FW	_	15	compound	_	_
15	montana	montana	FW	FW	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	A.	a.	FW	FW	_	20	compound	_	_
18	chamissonis	chamissonis	FW	FW	_	20	compound	_	_
19	ssp.	ssp.	FW	FW	_	20	compound	_	_
20	foliosa	foliosa	FW	FW	_	15	conj	_	_
21	,	,	,	,	_	2	punct	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	used	use	VBN	VBN	_	0	root	_	_
24	therapeutically	therapeutically	RB	RB	_	23	advmod	_	_
25	as	as	IN	IN	_	27	case	_	_
26	anti-inflammatory	anti-inflammatory	JJ	JJ	_	27	amod	_	_
27	remedies	remedy	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	ingredients	ingredient	NNS	NNS	_	11	nsubj	_	_
4	mediating	mediate	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	pharmacological	pharmacological	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	4	dobj	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	mainly	mainly	RB	RB	_	11	advmod	_	_
10	sesquiterpene	sesquiterpene	NN	NN	_	11	compound	_	_
11	lactones	lactone	NNS	NNS	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	such	such	JJ	JJ	_	15	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	helenalin	helenalin	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	11alpha,13-dihydrohelenalin	11alpha,13-dihydrohelenalin	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	chamissonolid	chamissonolid	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
22	ester	ester	NN	NN	_	23	compound	_	_
23	derivatives	derivative	NNS	NNS	_	15	conj	_	_
24	.	.	.	.	_	11	punct	_	_

1	While	while	IN	IN	_	4	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	compounds	compound	NNS	NNS	_	4	nsubj	_	_
4	affect	affect	VBP	VBP	_	14	advcl	_	_
5	various	various	JJ	JJ	_	7	amod	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	processes	process	NNS	NNS	_	4	dobj	_	_
8	,	,	,	,	_	14	punct	_	_
9	current	current	JJ	JJ	_	10	amod	_	_
10	data	datum	NNS	NNS	_	14	nsubj	_	_
11	do	do	VBP	VBP	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	fully	fully	RB	RB	_	14	advmod	_	_
14	explain	explain	VB	VB	_	0	root	_	_
15	how	how	WRB	WRB	_	18	advmod	_	_
16	sesquiterpene	sesquiterpene	NN	NN	_	17	compound	_	_
17	lactones	lactone	NNS	NNS	_	18	nsubj	_	_
18	exert	exert	VBP	VBP	_	14	ccomp	_	_
19	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
20	anti-inflammatory	anti-inflammatory	JJ	JJ	_	21	amod	_	_
21	effect	effect	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	helenalin	helenalin	NN	NN	_	19	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	,	,	,	,	_	5	punct	_	_
9	to	to	TO	TO	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	much	much	RB	RB	_	12	advmod	_	_
12	lesser	lesser	JJR	JJR	_	13	amod	_	_
13	degree	degree	NN	NN	_	5	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	11alpha,13-dihydrohelenalin	11alpha,13-dihydrohelenalin	NN	NN	_	5	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	chamissonolid	chamissonolid	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	5	punct	_	_
19	inhibit	inhibit	VBP	VBP	_	2	ccomp	_	_
20	activation	activation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	20	nmod	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	23	dep	_	_
25	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	difference	difference	NN	NN	_	19	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	efficacy	efficacy	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	correlates	correlate	VBZ	VBZ	_	2	acl:relcl	_	_
8	with	with	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	compounds	compound	NNS	NNS	_	13	nmod:poss	_	_
11	'	'	POS	POS	_	13	case	_	_
12	anti-inflammatory	anti-inflammatory	JJ	JJ	_	13	amod	_	_
13	potency	potency	NN	NN	_	7	nmod	_	_
14	in	in	FW	FW	_	13	amod	_	_
15	vivo	vivo	FW	FW	_	14	dep	_	_
16	,	,	,	,	_	2	punct	_	_
17	may	may	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	explained	explain	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	21	case	_	_
21	differences	difference	NNS	NNS	_	19	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	structure	structure	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	conformation	conformation	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	19	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	16	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	4	nsubj	_	_
4	resides	reside	VBZ	VBZ	_	1	acl:relcl	_	_
5	in	in	IN	IN	_	10	case	_	_
6	an	a	DT	DT	_	10	det	_	_
7	inactive	inactive	JJ	JJ	_	10	amod	_	_
8	,	,	,	,	_	10	punct	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	4	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	unstimulated	unstimulated	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	activated	activate	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	phosphorylation	phosphorylation	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	degradation	degradation	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
23	inhibitory	inhibitory	JJ	JJ	_	24	amod	_	_
24	subunit	subunit	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	IkappaB	ikappab	NN	NN	_	24	appos	_	_
27	.	.	.	.	_	16	punct	_	_

1	Helenalin	helenalin	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	response	response	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	four	four	CD	CD	_	10	nummod	_	_
9	different	different	JJ	JJ	_	10	amod	_	_
10	stimuli	stimulus	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	T-cells	t-cell	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	B-cells	b-cell	NNS	NNS	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	epithelial	epithelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	conj	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	abrogates	abrogate	VBZ	VBZ	_	2	conj	_	_
20	kappaB-driven	kappab-driven	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	selective	selective	JJ	JJ	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	as	as	IN	IN	_	25	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activity	activity	NN	NN	_	25	nsubjpass	_	_
9	of	of	IN	IN	_	13	case	_	_
10	four	four	CD	CD	_	13	nummod	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	Oct-1	oct-1	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	15	punct	_	_
17	TBP	tbp	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	Sp1	sp1	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	STAT	stat	NN	NN	_	15	conj	_	_
22	5	5	CD	CD	_	21	nummod	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	affected	affect	VBN	VBN	_	4	advcl	_	_
26	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	due	due	JJ	JJ	_	2	ccomp	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	direct	direct	JJ	JJ	_	11	amod	_	_
11	modification	modification	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	active	active	JJ	JJ	_	16	amod	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	heterodimer	heterodimer	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Rather	rather	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	helenalin	helenalin	NN	NN	_	4	nsubj	_	_
4	modifies	modify	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	NF-kappaB/IkappaB	nf-kappab/ikappab	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	4	punct	_	_
9	preventing	prevent	VBG	VBG	_	4	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	release	release	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IkappaB	ikappab	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	anti-inflammatory	anti-inflammatory	JJ	JJ	_	10	amod	_	_
10	effect	effect	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	sesquiterpene	sesquiterpene	NN	NN	_	13	compound	_	_
13	lactones	lactone	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	differs	differ	VBZ	VBZ	_	10	acl:relcl	_	_
17	from	from	IN	IN	_	18	case	_	_
18	that	that	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	other	other	JJ	JJ	_	23	amod	_	_
21	nonsteroidal	nonsteroidal	JJ	JJ	_	23	amod	_	_
22	anti-inflammatory	anti-inflammatory	JJ	JJ	_	23	amod	_	_
23	drugs	drug	NNS	NNS	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	NSAIDs	nsaid	NNS	NNS	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	23	punct	_	_
28	indomethacin	indomethacin	NN	NN	_	23	appos	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	acetyl	acetyl	NN	NN	_	32	compound	_	_
31	salicylic	salicylic	JJ	JJ	_	32	amod	_	_
32	acid	acid	NN	NN	_	28	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	Dysregulation	dysregulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	oxidized	oxidize	VBN	VBN	_	10	amod	_	_
9	low-density	low-density	JJ	JJ	_	10	amod	_	_
10	lipoprotein	lipoprotein	NN	NN	_	1	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	10	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	10	compound	_	_
3	B	b	NN	NN	_	10	compound	_	_
4	(	(	-LRB-	-LRB-	_	10	punct	_	_
5	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
6	B	b	NN	NN	_	10	compound	_	_
7	)	)	-RRB-	-RRB-	_	10	punct	_	_
8	/Rel	/rel	NN	NN	_	10	compound	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	13	nsubjpass	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	involved	involve	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	atherosclerosis	atherosclerosis	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	as	as	IN	IN	_	19	mark	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	suggested	suggest	VBN	VBN	_	13	advcl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	presence	presence	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	activated	activate	VBN	VBN	_	26	amod	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	atherosclerotic	atherosclerotic	JJ	JJ	_	30	amod	_	_
30	lesions	lesion	NNS	NNS	_	22	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	investigate	investigate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	oxidized	oxidize	VBN	VBN	_	14	amod	_	_
14	LDL	ldl	NN	NN	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	oxLDL	oxldl	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	on	on	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	system	system	NN	NN	_	11	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	human	human	JJ	JJ	_	27	amod	_	_
25	THP-1	thp-1	NN	NN	_	27	compound	_	_
26	monocytic	monocytic	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	as	as	RB	RB	_	27	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	adherent	adherent	JJ	JJ	_	32	amod	_	_
32	monocytes	monocyte	NNS	NNS	_	27	conj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	short-term	short-term	JJ	JJ	_	6	amod	_	_
6	incubation	incubation	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	oxLDL	oxldl	NN	NN	_	6	nmod	_	_
12	activated	activate	VBD	VBD	_	3	ccomp	_	_
13	p50/p65	p50/p65	NN	NN	_	12	dobj	_	_
14	containing	contain	VBG	VBG	_	13	acl	_	_
15	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	dimers	dimer	NNS	NNS	_	14	dobj	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	induced	induce	VBD	VBD	_	12	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	target	target	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	IL-8	il-8	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	antioxidant	antioxidant	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	H2O2	h2o2	NN	NN	_	13	compound	_	_
13	scavenger	scavenger	NN	NN	_	10	conj	_	_
14	pyrrolidine	pyrrolidine	NN	NN	_	15	compound	_	_
15	dithiocarbamate	dithiocarbamate	NN	NN	_	10	dep	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	proteasome	proteasome	NN	NN	_	19	compound	_	_
19	inhibitor	inhibitor	NN	NN	_	10	conj	_	_
20	PSI	psi	NN	NN	_	19	dep	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	oxLDL-induced	oxldl-induced	JJ	JJ	_	5	amod	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	accompanied	accompany	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	initial	initial	JJ	JJ	_	11	amod	_	_
11	depletion	depletion	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B-alpha	b-alpha	NN	NN	_	11	nmod	_	_
16	followed	follow	VBN	VBN	_	7	dep	_	_
17	by	by	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	slight	slight	JJ	JJ	_	21	amod	_	_
20	transient	transient	JJ	JJ	_	19	dep	_	_
21	increase	increase	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	level	level	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	this	this	DT	DT	_	28	det	_	_
27	inhibitor	inhibitor	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	long-term	long-term	JJ	JJ	_	5	amod	_	_
5	treatment	treatment	NN	NN	_	8	nsubj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	oxLDL	oxldl	NN	NN	_	5	nmod	_	_
8	prevented	prevent	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	11	amod	_	_
11	depletion	depletion	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B-alpha	b-alpha	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	accompanied	accompany	VBN	VBN	_	8	advcl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	an	a	DT	DT	_	20	det	_	_
20	inhibition	inhibition	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	both	both	CC	CC	_	25	cc:preconj	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expression	expression	NN	NN	_	25	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	tumor	tumor	NN	NN	_	32	compound	_	_
31	necrosis	necrosis	NN	NN	_	32	compound	_	_
32	factor-alpha	factor-alpha	NN	NN	_	28	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	interleukin-1	interleukin-1	NN	NN	_	35	compound	_	_
35	beta	beta	NN	NN	_	32	conj	_	_
36	genes	gene	NNS	NNS	_	32	dep	_	_
37	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	additional	additional	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	oxLDL	oxldl	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	modulator	modulator	NN	NN	_	5	ccomp	_	_
12	of	of	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	suggest	suggest	VBP	VBP	_	3	conj	_	_
17	that	that	IN	IN	_	26	mark	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	dys	dys	JJ	JJ	_	26	nsubj	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	regulation	regulation	NN	NN	_	19	dep	_	_
22	of	of	IN	IN	_	24	case	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B/Rel	b/rel	NN	NN	_	19	nmod	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	likely	likely	JJ	JJ	_	16	ccomp	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	play	play	VB	VB	_	26	xcomp	_	_
29	an	a	DT	DT	_	31	det	_	_
30	important	important	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	atherogenesis	atherogenesis	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	6	nsubj	_	_
3	latent	latent	JJ	JJ	_	5	amod	_	_
4	membrane	membrane	NN	NN	_	5	compound	_	_
5	protein-1	protein-1	NN	NN	_	2	dep	_	_
6	triggers	trigger	VBZ	VBZ	_	0	root	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	via	via	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	c-Jun	c-jun	NN	NN	_	14	compound	_	_
12	N-terminal	n-terminal	JJ	JJ	_	14	amod	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	cascade	cascade	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus	virus	NN	NN	_	14	nsubj	_	_
4	latent	latent	JJ	JJ	_	6	amod	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	protein-1	protein-1	NN	NN	_	3	dep	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	LMP-1	lmp-1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	an	a	DT	DT	_	14	det	_	_
12	integral	integral	JJ	JJ	_	14	amod	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	0	root	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	transforms	transform	VBZ	VBZ	_	14	acl:relcl	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	16	dobj	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	essential	essential	JJ	JJ	_	16	conj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	EBV-mediated	ebv-mediated	JJ	JJ	_	24	amod	_	_
23	B-cell	b-cell	NN	NN	_	24	compound	_	_
24	immortalization	immortalization	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	LMP-1	lmp-1	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	trigger	trigger	VB	VB	_	4	xcomp	_	_
7	cellular	cellular	JJ	JJ	_	10	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	dobj	_	_
11	which	which	WDT	WDT	_	18	nsubj	_	_
12	,	,	,	,	_	18	punct	_	_
13	however	however	RB	RB	_	18	advmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	can	can	MD	MD	_	18	aux	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	fully	fully	RB	RB	_	18	advmod	_	_
18	explain	explain	VB	VB	_	10	acl:relcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	oncogenic	oncogenic	JJ	JJ	_	21	amod	_	_
21	potential	potential	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	LMP-1	lmp-1	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	LMP-1	lmp-1	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	AP-1	ap-1	NN	NN	_	13	compound	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	dimer	dimer	NN	NN	_	13	appos	_	_
17	of	of	IN	IN	_	21	case	_	_
18	Jun/Jun	jun/jun	NN	NN	_	21	compound	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Jun/Fos	jun/fos	NN	NN	_	18	conj	_	_
21	proteins	protein	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	LMP-1	lmp-1	NN	NN	_	2	compound	_	_
2	effects	effect	NNS	NNS	_	6	nsubjpass	_	_
3	on	on	IN	IN	_	4	case	_	_
4	AP-1	ap-1	NN	NN	_	2	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	0	root	_	_
7	through	through	IN	IN	_	8	case	_	_
8	activation	activation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	17	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	c-Jun	c-jun	NN	NN	_	13	compound	_	_
12	N-terminal	n-terminal	JJ	JJ	_	13	amod	_	_
13	kinase	kinase	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	JNK	jnk	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	cascade	cascade	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	20	cc	_	_
20	not	not	RB	RB	_	17	cc	_	_
21	the	the	DT	DT	_	28	det	_	_
22	extracellular	extracellular	JJ	JJ	_	24	amod	_	_
23	signal-regulated	signal-regulated	JJ	JJ	_	24	amod	_	_
24	kinase	kinase	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Erk	erk	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	pathway	pathway	NN	NN	_	17	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Consequently	consequently	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	LMP-1	lmp-1	NN	NN	_	4	nsubj	_	_
4	triggers	trigger	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	c-Jun	c-jun	NN	NN	_	12	compound	_	_
10	N-terminal	n-terminal	JJ	JJ	_	12	amod	_	_
11	transactivation	transactivation	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	6	nmod	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	known	know	VBN	VBN	_	12	acl:relcl	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	15	xcomp	_	_
19	upon	upon	IN	IN	_	21	case	_	_
20	JNK-mediated	jnk-mediated	JJ	JJ	_	21	amod	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	23	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	55	55	CD	CD	_	9	nummod	_	_
7	C-terminal	c-terminal	JJ	JJ	_	9	amod	_	_
8	amino	amino	NN	NN	_	9	compound	_	_
9	acids	acid	NNS	NNS	_	23	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	LMP-1	lmp-1	NN	NN	_	13	compound	_	_
13	molecule	molecule	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	9	cc	_	_
17	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
18	TRAF	traf	NN	NN	_	20	compound	_	_
19	interaction	interaction	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	9	conj	_	_
21	,	,	,	,	_	9	punct	_	_
22	are	be	VBP	VBP	_	23	cop	_	_
23	essential	essential	JJ	JJ	_	3	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	AP-1	ap-1	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	JNK-mediated	jnk-mediated	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	AP-1	ap-1	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	the	the	DT	DT	_	9	det	_	_
8	direct	direct	JJ	JJ	_	9	amod	_	_
9	output	output	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	LMP-1-triggered	lmp-1-triggered	JJ	JJ	_	12	amod	_	_
12	signaling	signaling	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	shown	show	VBN	VBN	_	9	advcl	_	_
16	by	by	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	inducible	inducible	JJ	JJ	_	20	amod	_	_
19	LMP-1	lmp-1	NN	NN	_	20	compound	_	_
20	mutant	mutant	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	5	det	_	_
3	tetracycline-regulated	tetracycline-regulated	JJ	JJ	_	5	amod	_	_
4	LMP-1	lmp-1	NN	NN	_	5	compound	_	_
5	allele	allele	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	1	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	JNK	jnk	NN	NN	_	14	nsubj	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	an	a	DT	DT	_	14	det	_	_
14	effector	effector	NN	NN	_	8	ccomp	_	_
15	of	of	IN	IN	_	18	case	_	_
16	non-cytotoxic	non-cytotoxic	JJ	JJ	_	18	amod	_	_
17	LMP-1	lmp-1	NN	NN	_	18	compound	_	_
18	signaling	signaling	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	the	the	DT	DT	_	26	det	_	_
24	physiological	physiological	JJ	JJ	_	26	amod	_	_
25	target	target	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	appos	_	_
27	of	of	IN	IN	_	28	case	_	_
28	EBV	ebv	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	reveal	reveal	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	effector	effector	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	LMP-1	lmp-1	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	SEK/JNK/c-Jun/AP-1	sek/jnk/c-jun/ap-1	NN	NN	_	15	compound	_	_
15	pathway	pathway	NN	NN	_	11	appos	_	_
16	,	,	,	,	_	9	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	contributes	contribute	VBZ	VBZ	_	9	acl:relcl	_	_
19	to	to	TO	TO	_	21	case	_	_
20	our	we	PRP$	PRP$	_	21	nmod:poss	_	_
21	understanding	understanding	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	immortalizing	immortalizing	JJ	JJ	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	transforming	transforming	JJ	JJ	_	24	conj	_	_
27	potential	potential	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	LMP-1	lmp-1	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	CD30-dependent	cd30-dependent	JJ	JJ	_	2	amod	_	_
2	degradation	degradation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TRAF2	traf2	NN	NN	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	implications	implication	NNS	NNS	_	2	dep	_	_
7	for	for	IN	IN	_	9	case	_	_
8	negative	negative	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	TRAF	traf	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	control	control	NN	NN	_	9	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	survival	survival	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	CD30	cd30	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	cell-surface	cell-surface	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	augment	augment	VB	VB	_	5	acl:relcl	_	_
9	lymphocyte	lymphocyte	NN	NN	_	8	dobj	_	_
10	activation	activation	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	survival	survival	NN	NN	_	9	conj	_	_
13	through	through	IN	IN	_	15	case	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	8	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	15	acl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	17	dobj	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	20	dep	_	_
22	.	.	.	.	_	5	punct	_	_

1	CD30	cd30	NN	NN	_	8	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	however	however	RB	RB	_	8	advmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	also	also	RB	RB	_	8	advmod	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	implicated	implicate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	apoptotic	apoptotic	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	death	death	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	one	one	CD	CD	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	CD30	cd30	NN	NN	_	12	compound	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transduction	transduction	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	3	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	render	render	VB	VB	_	13	xcomp	_	_
16	cells	cell	NNS	NNS	_	17	nsubj	_	_
17	sensitive	sensitive	JJ	JJ	_	15	xcomp	_	_
18	to	to	TO	TO	_	19	case	_	_
19	apoptosis	apoptosis	NN	NN	_	17	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	28	case	_	_
22	the	the	DT	DT	_	28	det	_	_
23	type	type	NN	NN	_	28	compound	_	_
24	1	1	CD	CD	_	28	nummod	_	_
25	tumor	tumor	NN	NN	_	28	compound	_	_
26	necrosis	necrosis	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	receptor	receptor	NN	NN	_	20	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TNFR1	tnfr1	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	sensitization	sensitization	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	dependent	dependent	JJ	JJ	_	0	root	_	_
5	on	on	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TRAF-binding	traf-binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	4	nmod	_	_
9	within	within	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	CD30	cd30	NN	NN	_	8	nmod	_	_
12	cytoplasmic	cytoplasmic	JJ	JJ	_	13	amod	_	_
13	domain	domain	NN	NN	_	11	dep	_	_
14	.	.	.	.	_	4	punct	_	_

1	One	one	CD	CD	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	binds	bind	VBZ	VBZ	_	1	acl:relcl	_	_
7	to	to	TO	TO	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	sites	site	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	TRAF2	traf2	NN	NN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	16	det	_	_
14	signal	signal	NN	NN	_	16	compound	_	_
15	transduction	transduction	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	11	appos	_	_
17	that	that	WDT	WDT	_	20	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	utilized	utilize	VBN	VBN	_	16	acl:relcl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	TNFR1	tnfr1	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	mediate	mediate	VB	VB	_	20	xcomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	activation	activation	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	several	several	JJ	JJ	_	30	amod	_	_
29	downstream	downstream	JJ	JJ	_	30	amod	_	_
30	kinases	kinase	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factors	factor	NNS	NNS	_	30	conj	_	_
34	.	.	.	.	_	11	punct	_	_

1	During	during	IN	IN	_	4	case	_	_
2	CD30	cd30	NN	NN	_	4	compound	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transduction	transduction	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	found	find	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	binding	binding	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TRAF2	traf2	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	cytoplasmic	cytoplasmic	JJ	JJ	_	15	amod	_	_
15	domain	domain	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CD30	cd30	NN	NN	_	15	nmod	_	_
18	results	result	VBZ	VBZ	_	7	ccomp	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	rapid	rapid	JJ	JJ	_	22	amod	_	_
22	depletion	depletion	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	TRAF2	traf2	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	associated	associate	VBN	VBN	_	28	amod	_	_
28	protein	protein	NN	NN	_	24	conj	_	_
29	TRAF1	traf1	NN	NN	_	28	dep	_	_
30	by	by	IN	IN	_	31	case	_	_
31	proteolysis	proteolysis	NN	NN	_	22	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	model	model	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	9	nmod	_	_
8	CD30	cd30	NN	NN	_	9	nsubj	_	_
9	limits	limit	VBZ	VBZ	_	5	acl:relcl	_	_
10	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
11	own	own	JJ	JJ	_	12	amod	_	_
12	ability	ability	NN	NN	_	9	dobj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	transduce	transduce	VB	VB	_	12	acl	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	survival	survival	NN	NN	_	17	compound	_	_
17	signals	signal	NNS	NNS	_	14	dobj	_	_
18	through	through	IN	IN	_	20	case	_	_
19	signal-coupled	signal-coupled	JJ	JJ	_	20	amod	_	_
20	depletion	depletion	NN	NN	_	9	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	TRAF2	traf2	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Depletion	depletion	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	intracellular	intracellular	JJ	JJ	_	4	amod	_	_
4	TRAF2	traf2	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
7	coassociated	coassociated	JJ	JJ	_	8	amod	_	_
8	proteins	protein	NNS	NNS	_	4	conj	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	sensitivity	sensitivity	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cell	cell	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	undergoing	undergo	VBG	VBG	_	12	acl	_	_
18	apoptosis	apoptosis	NN	NN	_	17	dobj	_	_
19	during	during	IN	IN	_	20	case	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	death-inducing	death-inducing	JJ	JJ	_	23	amod	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	such	such	JJ	JJ	_	26	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	TNFR1	tnfr1	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Consistent	consistent	JJ	JJ	_	14	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	expression	expression	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dominant-negative	dominant-negative	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TRAF2	traf2	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	potentiate	potentiate	VB	VB	_	14	xcomp	_	_
17	TNFR1-mediated	tnfr1-mediated	JJ	JJ	_	18	amod	_	_
18	death	death	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	through	through	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	24	nmod	_	_
9	CD30	cd30	NN	NN	_	24	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	as	as	RB	RB	_	9	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	TRAF-binding	traf-binding	JJ	JJ	_	16	amod	_	_
16	members	member	NNS	NNS	_	9	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TNFR	tnfr	NN	NN	_	20	compound	_	_
20	superfamily	superfamily	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	negatively	negatively	RB	RB	_	24	advmod	_	_
24	regulate	regulate	VB	VB	_	6	acl:relcl	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	survival	survival	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	3	punct	_	_

1	PU.1/Pip	pu.1/pip	NN	NN	_	10	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	basic	basic	JJ	JJ	_	9	amod	_	_
4	helix	helix	NN	NN	_	9	compound	_	_
5	loop	loop	NN	NN	_	9	compound	_	_
6	helix	helix	NN	NN	_	9	compound	_	_
7	zipper	zipper	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	1	conj	_	_
10	interact	interact	VBP	VBP	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	binding	bind	VBG	VBG	_	13	amod	_	_
13	sites	site	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CD20	cd20	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	help	help	VB	VB	_	10	xcomp	_	_
20	confer	confer	VB	VB	_	19	ccomp	_	_
21	lineage-	lineage-	NN	NN	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	stage-specific	stage-specific	JJ	JJ	_	21	conj	_	_
24	expression	expression	NN	NN	_	20	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	CD20	cd20	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	B	b	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	CD20	cd20	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	B-lineage-specific	b-lineage-specific	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	0	root	_	_
6	expressed	express	VBN	VBN	_	5	acl	_	_
7	at	at	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	pre-B-cell	pre-b-cell	JJ	JJ	_	10	amod	_	_
10	stage	stage	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	B-cell	b-cell	NN	NN	_	13	compound	_	_
13	development	development	NN	NN	_	10	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	disappears	disappear	VBZ	VBZ	_	5	acl:relcl	_	_
16	on	on	IN	IN	_	17	case	_	_
17	differentiation	differentiation	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	plasma	plasma	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	such	such	JJ	JJ	_	5	advcl	_	_
3	,	,	,	,	_	5	punct	_	_
4	it	it	PRP	PRP	_	5	nsubj	_	_
5	serves	serve	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	excellent	excellent	JJ	JJ	_	9	amod	_	_
9	paradigm	paradigm	NN	NN	_	5	nmod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	study	study	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	19	case	_	_
14	lineage	lineage	NN	NN	_	19	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	developmental	developmental	JJ	JJ	_	17	amod	_	_
17	stage-specific	stage-specific	JJ	JJ	_	14	conj	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vivo	vivo	FW	FW	_	2	dep	_	_
4	footprinting	footprinting	NN	NN	_	1	dobj	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	1	parataxis	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	sites	site	NNS	NNS	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	promoter	promoter	NN	NN	_	8	nmod	_	_
12	at	at	IN	IN	_	13	case	_	_
13	-45	-45	CD	CD	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-160	-160	CD	CD	_	13	conj	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	occupied	occupy	VBN	VBN	_	8	acl:relcl	_	_
19	only	only	RB	RB	_	23	advmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	CD20+	cd20+	JJ	JJ	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	-45	-45	CD	CD	_	3	nummod	_	_
3	site	site	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	an	a	DT	DT	_	7	det	_	_
6	E	e	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
10	basic	basic	JJ	JJ	_	12	amod	_	_
11	helix-loop-helix-zipper	helix-loop-helix-zipper	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	9	dobj	_	_
13	whereas	whereas	IN	IN	_	20	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	-160	-160	CD	CD	_	16	nummod	_	_
16	site	site	NN	NN	_	20	nsubj	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	a	a	DT	DT	_	20	det	_	_
19	composite	composite	JJ	JJ	_	20	amod	_	_
20	PU.1	pu.1	NN	NN	_	7	advcl	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Pip	pip	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	site	site	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	10	nsubj	_	_
3	with	with	IN	IN	_	5	case	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	constructs	construct	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	various	various	JJ	JJ	_	9	amod	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	vectors	vector	NNS	NNS	_	5	conj	_	_
10	verified	verify	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	importance	importance	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	sites	site	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	composite	composite	JJ	JJ	_	3	amod	_	_
3	PU.1	pu.1	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Pip	pip	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	3	conj	_	_
7	likely	likely	RB	RB	_	8	advmod	_	_
8	accounts	account	VBZ	VBZ	_	0	root	_	_
9	for	for	IN	IN	_	14	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	lineage	lineage	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	stage-specific	stage-specific	JJ	JJ	_	11	conj	_	_
14	expression	expression	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CD20	cd20	NN	NN	_	14	nmod	_	_
17	whereas	whereas	IN	IN	_	24	mark	_	_
18	the	the	DT	DT	_	23	det	_	_
19	CD20	cd20	NN	NN	_	23	compound	_	_
20	E	e	NN	NN	_	23	compound	_	_
21	box	box	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	24	nsubj	_	_
24	enhance	enhance	VBP	VBP	_	8	advcl	_	_
25	overall	overall	JJ	JJ	_	27	amod	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	dobj	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	link	link	VB	VB	_	24	conj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	promoter	promoter	NN	NN	_	30	dobj	_	_
33	to	to	TO	TO	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	distant	distant	JJ	JJ	_	36	amod	_	_
36	enhancer	enhancer	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	8	punct	_	_

1	TNFalpha	tnfalpha	NN	NN	_	2	nsubj	_	_
2	cooperates	cooperate	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	A	a	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	2	nmod	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	synergistically	synergistically	RB	RB	_	11	advmod	_	_
11	increase	increase	VB	VB	_	2	xcomp	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	LTR	ltr	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	11	dobj	_	_
15	via	via	IN	IN	_	20	case	_	_
16	downstream	downstream	JJ	JJ	_	20	amod	_	_
17	TRE-like	tre-like	JJ	JJ	_	20	amod	_	_
18	cAMP	camp	NN	NN	_	20	compound	_	_
19	response	response	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	11	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Activating	activate	VBG	VBG	_	2	amod	_	_
2	protein-1	protein-1	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	AP-1	ap-1	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	binding	binding	NN	NN	_	14	nsubj	_	_
7	TPA	tpa	NN	NN	_	9	compound	_	_
8	responsive	responsive	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	6	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TRE	tre	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	located	located	JJ	JJ	_	0	root	_	_
15	downstream	downstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	initiation	initiation	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	U5	u5	NN	NN	_	24	compound	_	_
24	region	region	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	30	case	_	_
26	the	the	DT	DT	_	30	det	_	_
27	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
28	long	long	JJ	JJ	_	30	amod	_	_
29	terminal	terminal	JJ	JJ	_	30	amod	_	_
30	repeat	repeat	NN	NN	_	24	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	LTR	ltr	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	downstream	downstream	JJ	JJ	_	4	amod	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	elements	element	NNS	NNS	_	10	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	termed	term	VBN	VBN	_	4	acl	_	_
7	DSE	dse	NN	NN	_	6	xcomp	_	_
8	,	,	,	,	_	4	punct	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	bind	bind	VB	VB	_	0	root	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	AP-1	ap-1	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	CREB/ATF	creb/atf	NN	NN	_	12	conj	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	14	dep	_	_
17	.	.	.	.	_	10	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	DSE	dse	NN	NN	_	11	nsubj	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	also	also	RB	RB	_	11	advmod	_	_
10	cAMP-responsive	camp-responsive	JJ	JJ	_	11	amod	_	_
11	elements	element	NNS	NNS	_	4	ccomp	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	CRE	cre	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	since	since	IN	IN	_	18	mark	_	_
17	they	they	PRP	PRP	_	18	nsubj	_	_
18	mediated	mediate	VBD	VBD	_	11	advcl	_	_
19	activation	activation	NN	NN	_	20	compound	_	_
20	signals	signal	NNS	NNS	_	18	dobj	_	_
21	elicited	elicit	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	cholera	cholera	NN	NN	_	24	compound	_	_
24	toxin	toxin	NN	NN	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Ctx	ctx	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	24	punct	_	_
29	a	a	DT	DT	_	31	det	_	_
30	potent	potent	JJ	JJ	_	31	amod	_	_
31	activator	activator	NN	NN	_	24	appos	_	_
32	of	of	IN	IN	_	43	case	_	_
33	the	the	DT	DT	_	43	det	_	_
34	cAMP-dependent	camp-dependent	JJ	JJ	_	43	amod	_	_
35	protein	protein	NN	NN	_	37	compound	_	_
36	kinase	kinase	NN	NN	_	37	compound	_	_
37	A	a	NN	NN	_	43	compound	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	PKA	pka	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	signal	signal	NN	NN	_	43	compound	_	_
42	transduction	transduction	NN	NN	_	43	compound	_	_
43	pathway	pathway	NN	NN	_	31	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	DSE	dse	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	mediate	mediate	VB	VB	_	7	ccomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	synergy	synergy	NN	NN	_	13	dobj	_	_
17	elicited	elicit	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	combination	combination	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Ctx	ctx	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	TNFalpha	tnfalpha	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	7	punct	_	_

1	Ctx	ctx	NN	NN	_	2	nsubj	_	_
2	combined	combine	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	TNFalpha	tnfalpha	NN	NN	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	IL-1beta	il-1beta	NN	NN	_	4	conj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	produce	produce	VB	VB	_	2	xcomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	synergistic	synergistic	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	p24	p24	NN	NN	_	14	compound	_	_
14	antigen	antigen	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	U1	u1	NN	NN	_	19	compound	_	_
18	promonocytic	promonocytic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	LTR	ltr	NN	NN	_	6	compound	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	constructs	construct	NNS	NNS	_	2	nmod	_	_
7	indicated	indicate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	14	mark	_	_
9	mutation	mutation	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	DSE	dse	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	9	nmod	_	_
14	abrogated	abrogate	VBD	VBD	_	7	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	LTR-mediated	ltr-mediated	JJ	JJ	_	17	amod	_	_
17	synergy	synergy	NN	NN	_	14	dobj	_	_
18	induced	induce	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	Ctx	ctx	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	TNFalpha	tnfalpha	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	14	punct	_	_
24	whereas	whereas	IN	IN	_	33	mark	_	_
25	the	the	DT	DT	_	26	det	_	_
26	synergy	synergy	NN	NN	_	33	nsubj	_	_
27	induced	induce	VBN	VBN	_	26	acl	_	_
28	by	by	IN	IN	_	29	case	_	_
29	Ctx	ctx	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	IL-1beta	il-1beta	NN	NN	_	29	conj	_	_
32	was	be	VBD	VBD	_	33	cop	_	_
33	unaffected	unaffected	JJ	JJ	_	14	advcl	_	_
34	,	,	,	,	_	14	punct	_	_
35	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
36	TNFalpha	tnfalpha	NN	NN	_	39	nsubj	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	IL-1beta	il-1beta	NN	NN	_	36	conj	_	_
39	cooperate	cooperate	VBP	VBP	_	35	ccomp	_	_
40	differently	differently	RB	RB	_	39	advmod	_	_
41	with	with	IN	IN	_	45	case	_	_
42	the	the	DT	DT	_	45	det	_	_
43	cAMP/PKA	camp/pka	NN	NN	_	45	compound	_	_
44	activation	activation	NN	NN	_	45	compound	_	_
45	pathway	pathway	NN	NN	_	39	nmod	_	_
46	to	to	TO	TO	_	47	mark	_	_
47	induce	induce	VB	VB	_	39	xcomp	_	_
48	HIV-1	hiv-1	NN	NN	_	49	compound	_	_
49	expression	expression	NN	NN	_	47	dobj	_	_
50	in	in	IN	IN	_	52	case	_	_
51	U1	u1	NN	NN	_	52	compound	_	_
52	cells	cell	NNS	NNS	_	47	nmod	_	_
53	.	.	.	.	_	7	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	DSE	dse	NN	NN	_	7	nsubj	_	_
4	are	be	VBP	VBP	_	7	cop	_	_
5	also	also	RB	RB	_	7	advmod	_	_
6	TRE	tre	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	10	advcl	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	assessed	assess	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	effect	effect	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	agonist	agonist	NN	NN	_	16	compound	_	_
16	combinations	combination	NNS	NNS	_	12	nmod	_	_
17	on	on	IN	IN	_	19	case	_	_
18	AP-1-dependent	ap-1-dependent	JJ	JJ	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	TNFalpha	tnfalpha	NN	NN	_	6	nsubj	_	_
2	as	as	RB	RB	_	1	cc	_	_
3	well	well	RB	RB	_	2	mwe	_	_
4	as	as	IN	IN	_	2	mwe	_	_
5	IL-1beta	il-1beta	NN	NN	_	1	conj	_	_
6	cooperated	cooperate	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	8	case	_	_
8	Ctx	ctx	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	produce	produce	VB	VB	_	6	xcomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	synergistic	synergistic	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	AP-1-mediated	ap-1-mediated	JJ	JJ	_	16	amod	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	TRE-like	tre-like	JJ	JJ	_	9	amod	_	_
7	cAMP-responsive	camp-responsive	JJ	JJ	_	9	amod	_	_
8	DSE	dse	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	15	nsubj	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	5'-untranslated	5'-untranslated	JJ	JJ	_	13	amod	_	_
13	leader	leader	NN	NN	_	9	nmod	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	mediate	mediate	VB	VB	_	3	ccomp	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	cooperativity	cooperativity	NN	NN	_	15	dobj	_	_
19	between	between	IN	IN	_	20	case	_	_
20	TNFalpha	tnfalpha	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	cAMP/PKA	camp/pka	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	9	mark	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	DSE	dse	NN	NN	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	TRE	tre	NN	NN	_	3	conj	_	_
6	sites	site	NNS	NNS	_	3	dep	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	bind	bind	VB	VB	_	14	advcl	_	_
10	CREB/ATF	creb/atf	NN	NN	_	11	compound	_	_
11	homodimers	homodimer	NNS	NNS	_	9	dobj	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	propose	propose	VBP	VBP	_	0	root	_	_
15	a	a	DT	DT	_	16	det	_	_
16	mechanism	mechanism	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	22	nmod	_	_
19	the	the	DT	DT	_	20	det	_	_
20	HIV-1	hiv-1	NN	NN	_	22	nsubj	_	_
21	DSE	dse	NN	NN	_	20	dep	_	_
22	bind	bind	VBP	VBP	_	16	acl:relcl	_	_
23	heterodimers	heterodimer	NNS	NNS	_	22	dobj	_	_
24	composed	compose	VBN	VBN	_	23	acl	_	_
25	of	of	IN	IN	_	27	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	AP-1	ap-1	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CREB/ATF	creb/atf	NN	NN	_	27	conj	_	_
30	proteins	protein	NNS	NNS	_	27	dep	_	_
31	.	.	.	.	_	14	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1997	1997	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	4	nsubj	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	2	dep	_	_
4	regulates	regulate	VBZ	VBZ	_	0	root	_	_
5	inducible	inducible	JJ	JJ	_	8	amod	_	_
6	Oct-2	oct-2	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	precursor	precursor	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	POU	pou	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	8	nsubj	_	_
5	Oct-1	oct-1	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Oct-2	oct-2	NN	NN	_	5	conj	_	_
8	regulate	regulate	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	octamer-dependent	octamer-dependent	JJ	JJ	_	13	amod	_	_
13	promoters	promoter	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	including	include	VBG	VBG	_	16	case	_	_
16	those	those	DT	DT	_	13	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	direct	direct	VBP	VBP	_	16	acl:relcl	_	_
19	transcription	transcription	NN	NN	_	18	dobj	_	_
20	from	from	IN	IN	_	23	case	_	_
21	rearranged	rearrange	VBN	VBN	_	23	amod	_	_
22	immunoglobulin	immunoglobulin	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	Oct-1	oct-1	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	constitutively	constitutively	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	2	acl:relcl	_	_
8	in	in	IN	IN	_	11	case	_	_
9	many	many	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	types	type	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	16	punct	_	_
13	Oct-2	oct-2	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	restricted	restricted	JJ	JJ	_	0	root	_	_
17	primarily	primarily	RB	RB	_	20	advmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	induced	induce	VBN	VBN	_	16	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	precursor	precursor	NN	NN	_	28	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	by	by	IN	IN	_	30	case	_	_
30	stimulation	stimulation	NN	NN	_	24	nmod	_	_
31	with	with	IN	IN	_	33	case	_	_
32	bacterial	bacterial	JJ	JJ	_	33	amod	_	_
33	lipopolysaccharide	lipopolysaccharide	NN	NN	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	LPS	lps	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	precise	precise	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	11	nsubj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	mediate	mediate	VBP	VBP	_	5	acl:relcl	_	_
8	this	this	DT	DT	_	10	det	_	_
9	induction	induction	NN	NN	_	10	compound	_	_
10	mechanism	mechanism	NN	NN	_	7	dobj	_	_
11	remain	remain	VBP	VBP	_	0	root	_	_
12	unknown	unknown	JJ	JJ	_	11	xcomp	_	_
13	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	monitored	monitor	VBD	VBD	_	0	root	_	_
8	Oct-2	oct-2	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	9	nmod	_	_
12	arrested	arrest	VBN	VBN	_	11	acl	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	an	a	DT	DT	_	21	det	_	_
20	LPS-responsive	lps-responsive	JJ	JJ	_	21	amod	_	_
21	member	member	NN	NN	_	17	appos	_	_
22	of	of	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	Rel	rel	NN	NN	_	27	compound	_	_
25	transcription	transcription	NN	NN	_	27	compound	_	_
26	factor	factor	NN	NN	_	27	compound	_	_
27	family	family	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Despite	despite	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	16	nmod	_	_
3	with	with	IN	IN	_	4	case	_	_
4	LPS	lps	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	disruption	disruption	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	precursor	precursor	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	led	lead	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	loss	loss	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	inducible	inducible	JJ	JJ	_	25	amod	_	_
22	Oct-2	oct-2	NN	NN	_	25	compound	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	19	nmod	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	25	advmod	_	_
28	and	and	CC	CC	_	19	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	suppression	suppression	NN	NN	_	19	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	Oct-2-directed	oct-2-directed	JJ	JJ	_	33	amod	_	_
33	transcription	transcription	NN	NN	_	30	nmod	_	_
34	in	in	FW	FW	_	35	compound	_	_
35	vivo	vivo	FW	FW	_	33	advmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	biochemical	biochemical	JJ	JJ	_	3	amod	_	_
3	defect	defect	NN	NN	_	4	nsubj	_	_
4	correlated	correlate	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	block	block	NN	NN	_	4	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	Oct-2	oct-2	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	8	nmod	_	_
13	at	at	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	level	level	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	transcription	transcription	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	whereas	whereas	IN	IN	_	25	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	25	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Oct-1	oct-1	NN	NN	_	21	nmod	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	unaffected	unaffected	JJ	JJ	_	4	advcl	_	_
26	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	9	nsubj	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	Oct-2	oct-2	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	under	under	IN	IN	_	8	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	control	control	NN	NN	_	2	ccomp	_	_
9	highlights	highlight	VBZ	VBZ	_	0	root	_	_
10	an	a	DT	DT	_	13	det	_	_
11	important	important	JJ	JJ	_	13	amod	_	_
12	cross-talk	cross-talk	NN	NN	_	13	compound	_	_
13	mechanism	mechanism	NN	NN	_	9	dobj	_	_
14	involving	involve	VBG	VBG	_	13	acl	_	_
15	two	two	CD	CD	_	19	nummod	_	_
16	distinct	distinct	JJ	JJ	_	19	amod	_	_
17	transcription	transcription	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	families	family	NNS	NNS	_	14	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	regulate	regulate	VBP	VBP	_	19	acl:relcl	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	lymphocyte	lymphocyte	NN	NN	_	24	compound	_	_
24	function	function	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	JAK2/STAT5	jak2/stat5	NN	NN	_	6	compound	_	_
6	pathway	pathway	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	commonly	commonly	RB	RB	_	9	advmod	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	signaling	signaling	NN	NN	_	9	nmod	_	_
12	through	through	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	IL-5	il-5	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	JAK	jak	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	Janus	janus	NN	NN	_	7	compound	_	_
5	kinase	kinase	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	family	family	NN	NN	_	25	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	kinases	kinase	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	STATs	stats	NNS	NNS	_	7	conj	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transducers	transducer	NNS	NNS	_	14	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	activators	activator	NNS	NNS	_	21	compound	_	_
20	of	of	IN	IN	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	17	conj	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	have	have	VBP	VBP	_	25	aux	_	_
24	been	be	VBN	VBN	_	25	auxpass	_	_
25	shown	show	VBN	VBN	_	0	root	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	activated	activate	VBN	VBN	_	25	xcomp	_	_
29	in	in	IN	IN	_	30	case	_	_
30	response	response	NN	NN	_	28	nmod	_	_
31	to	to	TO	TO	_	33	case	_	_
32	a	a	DT	DT	_	33	det	_	_
33	number	number	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	cytokines	cytokine	NNS	NNS	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	growth	growth	NN	NN	_	38	compound	_	_
38	factors	factor	NNS	NNS	_	35	conj	_	_
39	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	evaluated	evaluate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	JAK/STAT	jak/stat	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	8	nmod	_	_
12	upon	upon	IN	IN	_	18	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	interleukin-5	interleukin-5	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	hIL-5	hil-5	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	stimulation	stimulation	NN	NN	_	8	nmod	_	_
19	of	of	IN	IN	_	24	case	_	_
20	two	two	CD	CD	_	24	nummod	_	_
21	different	different	JJ	JJ	_	24	amod	_	_
22	hIL-5-responsive	hil-5-responsive	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	hIL-5	hil-5	NN	NN	_	34	compound	_	_
27	receptor	receptor	NN	NN	_	34	compound	_	_
28	alpha-subunit	alpha-subunit	NN	NN	_	34	compound	_	_
29	(	(	-LRB-	-LRB-	_	34	punct	_	_
30	hIL-5R	hil-5r	NN	NN	_	34	compound	_	_
31	alpha	alpha	NN	NN	_	34	compound	_	_
32	)	)	-RRB-	-RRB-	_	34	punct	_	_
33	cDNA-transfected	cdna-transfected	JJ	JJ	_	34	amod	_	_
34	TF-1	tf-1	NN	NN	_	24	conj	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	TF-h5R	tf-h5r	NN	NN	_	37	compound	_	_
37	alpha	alpha	NN	NN	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	and	and	CC	CC	_	24	cc	_	_
40	butyric-acid-treated	butyric-acid-treated	JJ	JJ	_	41	amod	_	_
41	YY-1	yy-1	NN	NN	_	24	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	YY-Bu	yy-bu	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	24	punct	_	_
46	and	and	CC	CC	_	24	cc	_	_
47	peripheral	peripheral	JJ	JJ	_	48	amod	_	_
48	eosinophils	eosinophil	NNS	NNS	_	24	conj	_	_
49	.	.	.	.	_	6	punct	_	_

1	Immunoprecipitation	immunoprecipitation	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	1	conj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	phosphorylation	phosphorylation	NN	NN	_	18	nsubjpass	_	_
11	of	of	IN	IN	_	12	case	_	_
12	JAK2	jak2	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	activation	activation	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	STAT5	stat5	NN	NN	_	14	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	induced	induce	VBN	VBN	_	7	ccomp	_	_
19	upon	upon	IN	IN	_	20	case	_	_
20	stimulation	stimulation	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	hIL-5	hil-5	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	all	all	DT	DT	_	27	det	_	_
25	three	three	CD	CD	_	27	nummod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	types	type	NNS	NNS	_	18	nmod	_	_
28	,	,	,	,	_	18	punct	_	_
29	while	while	IN	IN	_	34	mark	_	_
30	STAT1	stat1	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	34	nsubjpass	_	_
32	was	be	VBD	VBD	_	34	auxpass	_	_
33	only	only	RB	RB	_	34	advmod	_	_
34	observed	observe	VBN	VBN	_	18	advcl	_	_
35	in	in	IN	IN	_	36	case	_	_
36	eosinophils	eosinophil	NNS	NNS	_	34	nmod	_	_
37	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	JAK2/STAT5	jak2/stat5	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	11	nsubj	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	common	common	JJ	JJ	_	11	amod	_	_
10	JAK/STAT	jak/stat	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	3	ccomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	hIL-5-mediated	hil-5-mediated	JJ	JJ	_	14	amod	_	_
14	signal	signal	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Is	be	VBZ	VBZ	_	4	cop	_	_
2	celiac	celiac	JJ	JJ	_	3	amod	_	_
3	disease	disease	NN	NN	_	4	nsubj	_	_
4	due	due	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mimicry	mimicry	NN	NN	_	4	nmod	_	_
8	between	between	IN	IN	_	15	case	_	_
9	gliadin	gliadin	NN	NN	_	15	compound	_	_
10	peptide-HLA	peptide-hla	NN	NN	_	15	compound	_	_
11	class	class	NN	NN	_	15	compound	_	_
12	II	ii	CD	CD	_	15	nummod	_	_
13	molecule-T	molecule-t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	interactions	interaction	NNS	NNS	_	7	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	those	those	DT	DT	_	15	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	some	some	DT	DT	_	21	det	_	_
20	unidentified	unidentified	JJ	JJ	_	21	amod	_	_
21	superantigen	superantigen	NN	NN	_	17	nmod	_	_
22	?	?	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	paper	paper	NN	NN	_	3	nsubj	_	_
3	presents	present	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	etiology	etiology	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	pathogenesis	pathogenesis	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	celiac	celiac	JJ	JJ	_	14	amod	_	_
14	disease	disease	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	CD	cd	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	contention	contention	NN	NN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	CD	cd	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	triggered	trigger	VBN	VBN	_	4	ccomp	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	binding	binding	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	one	one	CD	CD	_	11	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	more	more	JJR	JJR	_	13	conj	_	_
16	gliadin	gliadin	NN	NN	_	17	compound	_	_
17	peptides	peptide	NNS	NNS	_	13	dep	_	_
18	to	to	TO	TO	_	23	case	_	_
19	CD-associated	cd-associated	JJ	JJ	_	23	amod	_	_
20	HLA	hla	NN	NN	_	23	compound	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	23	nummod	_	_
23	molecules	molecule	NNS	NNS	_	11	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	propose	propose	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	these	these	DT	DT	_	9	det	_	_
7	putative	putative	JJ	JJ	_	9	amod	_	_
8	CD	cd	NN	NN	_	9	compound	_	_
9	peptides	peptide	NNS	NNS	_	10	nsubj	_	_
10	bind	bind	VBP	VBP	_	4	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	oligosaccharide	oligosaccharide	NN	NN	_	13	compound	_	_
13	residues	residue	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	18	case	_	_
15	HLA	hla	NN	NN	_	18	compound	_	_
16	class	class	NN	NN	_	18	compound	_	_
17	II	ii	CD	CD	_	18	nummod	_	_
18	molecules	molecule	NNS	NNS	_	13	nmod	_	_
19	distal	distal	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	peptide-binding	peptide-binding	JJ	JJ	_	23	amod	_	_
23	groove	groove	NN	NN	_	19	nmod	_	_
24	invoking	invoke	VBG	VBG	_	23	acl	_	_
25	recognition	recognition	NN	NN	_	24	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	binding	binding	NN	NN	_	25	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	specialized	specialize	VBN	VBN	_	30	amod	_	_
30	subsets	subset	NNS	NNS	_	25	nmod	_	_
31	of	of	IN	IN	_	37	case	_	_
32	gamma	gamma	NN	NN	_	37	compound	_	_
33	delta	delta	NN	NN	_	37	compound	_	_
34	T	t	NN	NN	_	37	compound	_	_
35	cell	cell	NN	NN	_	37	compound	_	_
36	receptor-bearing	receptor-bearing	JJ	JJ	_	37	amod	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	30	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	these	these	DT	DT	_	8	det	_	_
5	gamma	gamma	NN	NN	_	8	compound	_	_
6	delta	delta	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	serves	serve	VBZ	VBZ	_	0	root	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	signal	signal	NN	NN	_	9	nmod	_	_
13	for	for	IN	IN	_	14	case	_	_
14	abrogation	abrogation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	oral	oral	JJ	JJ	_	17	amod	_	_
17	tolerance	tolerance	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	ingested	ingest	VBN	VBN	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	setting	set	VBG	VBG	_	20	acl	_	_
22	in	in	RP	RP	_	23	dep	_	_
23	motion	motion	NN	NN	_	21	nmod	_	_
24	a	a	DT	DT	_	25	det	_	_
25	series	series	NN	NN	_	21	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	immune	immune	JJ	JJ	_	28	amod	_	_
28	responses	response	NNS	NNS	_	25	nmod	_	_
29	directed	direct	VBN	VBN	_	25	acl	_	_
30	against	against	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	small	small	JJ	JJ	_	34	amod	_	_
33	intestinal	intestinal	JJ	JJ	_	34	amod	_	_
34	epithelium	epithelium	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	CD	cd	NN	NN	_	37	compound	_	_
37	patients	patient	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	CD	cd	NN	NN	_	2	compound	_	_
2	patients	patient	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	victimized	victimize	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	this	this	DT	DT	_	9	det	_	_
7	self-distructed	self-distructed	JJ	JJ	_	9	amod	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	4	nmod	_	_
10	because	because	IN	IN	_	12	case	_	_
11	of	of	IN	IN	_	12	case	_	_
12	inheritance	inheritance	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	certain	certain	JJ	JJ	_	15	amod	_	_
15	combinations	combination	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HLA-DQ	hla-dq	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	DR	dr	NN	NN	_	17	conj	_	_
20	haplotypes	haplotype	NNS	NNS	_	17	dep	_	_
21	.	.	.	.	_	4	punct	_	_

1	Dimers	dimer	NNS	NNS	_	11	nsubj	_	_
2	encoded	encode	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	HLA-DR	hla-dr	NN	NN	_	5	compound	_	_
5	haplotypes	haplotype	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	11	aux	_	_
7	be	be	VB	VB	_	11	cop	_	_
8	the	the	DT	DT	_	11	det	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	restriction	restriction	NN	NN	_	11	compound	_	_
11	elements	element	NNS	NNS	_	0	root	_	_
12	for	for	IN	IN	_	16	case	_	_
13	lectin-like	lectin-like	JJ	JJ	_	16	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	gliadin	gliadin	NN	NN	_	13	dep	_	_
16	peptides	peptide	NNS	NNS	_	11	nmod	_	_
17	while	while	IN	IN	_	32	mark	_	_
18	the	the	DT	DT	_	19	det	_	_
19	degree	degree	NN	NN	_	32	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	immune	immune	JJ	JJ	_	22	amod	_	_
22	suppression	suppression	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	or	or	CC	CC	_	25	cc	_	_
25	lack	lack	NN	NN	_	22	dep	_	_
26	thereof	thereof	RB	RB	_	25	advmod	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	to	to	TO	TO	_	30	case	_	_
29	ingested	ingest	VBN	VBN	_	30	amod	_	_
30	gliadins	gliadin	NNS	NNS	_	22	nmod	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	governed	govern	VBN	VBN	_	11	advcl	_	_
33	by	by	IN	IN	_	36	case	_	_
34	inherited	inherit	VBN	VBN	_	36	amod	_	_
35	HLA-DQ	hla-dq	NN	NN	_	36	compound	_	_
36	haplotypes	haplotype	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	speculate	speculate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	25	mark	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mimicry	mimicry	NN	NN	_	25	nsubj	_	_
8	between	between	IN	IN	_	9	case	_	_
9	one	one	CD	CD	_	7	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	more	more	JJR	JJR	_	9	conj	_	_
12	gliadin	gliadin	NN	NN	_	13	compound	_	_
13	peptides	peptide	NNS	NNS	_	9	dep	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	some	some	DT	DT	_	21	dep	_	_
16	,	,	,	,	_	21	punct	_	_
17	as	as	IN	IN	_	18	case	_	_
18	yet	yet	RB	RB	_	19	advmod	_	_
19	unidentified	unidentified	JJ	JJ	_	21	amod	_	_
20	,	,	,	,	_	21	punct	_	_
21	bacterial	bacterial	JJ	JJ	_	9	conj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	viral	viral	JJ	JJ	_	21	conj	_	_
24	superantigen	superantigen	NN	NN	_	21	dep	_	_
25	plays	play	VBZ	VBZ	_	4	ccomp	_	_
26	a	a	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	disease	disease	NN	NN	_	30	compound	_	_
30	pathogenesis	pathogenesis	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	CD40	cd40	NN	NN	_	5	compound	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	determinants	determinant	NNS	NNS	_	1	nmod	_	_
6	regulating	regulate	VBG	VBG	_	5	acl	_	_
7	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
8	factor-kappa	factor-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	7	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	important	important	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	9	mark	_	_
9	generating	generate	VBG	VBG	_	7	advcl	_	_
10	an	a	DT	DT	_	14	det	_	_
11	effective	effective	JJ	JJ	_	14	amod	_	_
12	humoral	humoral	JJ	JJ	_	11	dep	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	response	response	NN	NN	_	9	dobj	_	_
15	.	.	.	.	_	7	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	ligation	ligation	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	8	case	_	_
5	B	b	NN	NN	_	8	compound	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	activation	activation	NN	NN	_	8	compound	_	_
8	events	event	NNS	NNS	_	3	nmod	_	_
9	such	such	JJ	JJ	_	11	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	proliferation	proliferation	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	Ig	ig	NN	NN	_	14	compound	_	_
14	secretion	secretion	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	isotype	isotype	NN	NN	_	17	compound	_	_
17	switching	switching	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	up-regulation	up-regulation	NN	NN	_	11	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	surface	surface	NN	NN	_	24	compound	_	_
24	molecules	molecule	NNS	NNS	_	11	nmod	_	_
25	,	,	,	,	_	11	punct	_	_
26	as	as	RB	RB	_	11	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	the	the	DT	DT	_	30	det	_	_
30	generation	generation	NN	NN	_	11	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	memory	memory	NN	NN	_	34	compound	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Many	many	JJ	JJ	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	dependent	dependent	JJ	JJ	_	0	root	_	_
7	upon	upon	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD40	cd40	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	activate	activate	VB	VB	_	9	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	13	dobj	_	_
17	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	16	dep	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	16	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	CD40	cd40	NN	NN	_	6	compound	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	components	component	NNS	NNS	_	2	dobj	_	_
7	upstream	upstream	JJ	JJ	_	6	advmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	the	the	DT	DT	_	15	det	_	_
14	functional	functional	JJ	JJ	_	15	amod	_	_
15	consequences	consequence	NNS	NNS	_	6	conj	_	_
16	downstream	downstream	JJ	JJ	_	15	advmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	2	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	examined	examine	VBD	VBD	_	2	parataxis	_	_
24	mouse	mouse	NN	NN	_	27	compound	_	_
25	B	b	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	transfectants	transfectant	NNS	NNS	_	23	dobj	_	_
28	expressing	express	VBG	VBG	_	27	acl	_	_
29	wild-type	wild-type	JJ	JJ	_	28	dobj	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	mutant	mutant	JJ	JJ	_	32	amod	_	_
32	human	human	JJ	JJ	_	29	conj	_	_
33	CD40	cd40	NN	NN	_	29	dep	_	_
34	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	CD40	cd40	NN	NN	_	5	compound	_	_
4	cytoplasmic	cytoplasmic	JJ	JJ	_	5	amod	_	_
5	domain	domain	NN	NN	_	6	compound	_	_
6	truncation	truncation	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	point	point	NN	NN	_	9	compound	_	_
9	mutants	mutant	NNS	NNS	_	6	conj	_	_
10	defined	define	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	17	det	_	_
12	10-amino	10-amino	JJ	JJ	_	17	amod	_	_
13	acid	acid	NN	NN	_	17	compound	_	_
14	CD40	cd40	NN	NN	_	17	compound	_	_
15	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	determinant	determinant	NN	NN	_	10	dobj	_	_
18	required	require	VBN	VBN	_	17	acl	_	_
19	for	for	IN	IN	_	22	case	_	_
20	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	threonine	threonine	NN	NN	_	3	compound	_	_
3	residue	residue	NN	NN	_	32	nsubjpass	_	_
4	at	at	IN	IN	_	5	case	_	_
5	position	position	NN	NN	_	3	nmod	_	_
6	234	234	CD	CD	_	5	nummod	_	_
7	,	,	,	,	_	3	punct	_	_
8	previously	previously	RB	RB	_	9	advmod	_	_
9	shown	show	VBN	VBN	_	3	acl	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	important	important	JJ	JJ	_	9	xcomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	CD40	cd40	NN	NN	_	15	compound	_	_
15	association	association	NN	NN	_	12	nmod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	TNF	tnf	NN	NN	_	19	compound	_	_
18	receptor-associated	receptor-associated	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	2	2	CD	CD	_	19	nummod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TRAF2	traf2	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	19	punct	_	_
25	TRAF3	traf3	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	TRAF5	traf5	NN	NN	_	19	conj	_	_
29	,	,	,	,	_	3	punct	_	_
30	was	be	VBD	VBD	_	32	auxpass	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	required	require	VBN	VBN	_	0	root	_	_
33	for	for	IN	IN	_	36	case	_	_
34	NF-kappa	nf-kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	32	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	in	in	IN	IN	_	6	case	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	13	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	CD40-induced	cd40-induced	JJ	JJ	_	11	amod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	occur	occur	VB	VB	_	2	ccomp	_	_
14	independently	independently	RB	RB	_	13	advmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TRAF2	traf2	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	TRAF5	traf5	NN	NN	_	16	conj	_	_
19	association	association	NN	NN	_	16	dep	_	_
20	.	.	.	.	_	2	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	independent	independent	JJ	JJ	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transmembrane	transmembrane	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD40	cd40	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	suggesting	suggest	VBG	VBG	_	5	xcomp	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	it	it	PRP	PRP	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	independent	independent	JJ	JJ	_	13	ccomp	_	_
18	of	of	IN	IN	_	19	case	_	_
19	p23	p23	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	a	a	DT	DT	_	22	det	_	_
22	molecule	molecule	NN	NN	_	19	appos	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	associates	associate	VBZ	VBZ	_	22	acl:relcl	_	_
25	with	with	IN	IN	_	26	case	_	_
26	CD40	cd40	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	region	region	NN	NN	_	24	nmod	_	_
30	other	other	JJ	JJ	_	29	cc	_	_
31	than	than	IN	IN	_	30	dep	_	_
32	the	the	DT	DT	_	34	det	_	_
33	cytoplasmic	cytoplasmic	JJ	JJ	_	34	amod	_	_
34	domain	domain	NN	NN	_	29	conj	_	_
35	.	.	.	.	_	5	punct	_	_

1	Proteasome-dependent	proteasome-dependent	JJ	JJ	_	5	amod	_	_
2	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
3	kappa	kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	18	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	5	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	beta	beta	NN	NN	_	5	conj	_	_
17	degradation	degradation	NN	NN	_	5	dep	_	_
18	occurred	occur	VBD	VBD	_	0	root	_	_
19	downstream	downstream	JJ	JJ	_	18	xcomp	_	_
20	of	of	IN	IN	_	22	case	_	_
21	CD40	cd40	NN	NN	_	22	compound	_	_
22	ligation	ligation	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	preceded	precede	VBD	VBD	_	18	conj	_	_
25	CD40-mediated	cd40-mediated	JJ	JJ	_	29	amod	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	translocation	translocation	NN	NN	_	24	dobj	_	_
30	.	.	.	.	_	18	punct	_	_

1	CD40-	cd40-	NN	NN	_	11	nsubjpass	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	pervanadate-mediated	pervanadate-mediated	JJ	JJ	_	1	conj	_	_
4	I	i	NN	NN	_	8	compound	_	_
5	kappa	kappa	NN	NN	_	8	compound	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	1	dep	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	correlated	correlate	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	ability	ability	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CD40	cd40	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	7	acl	_	_
12	Ab	ab	NN	NN	_	13	compound	_	_
13	secretion	secretion	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	up-regulation	up-regulation	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	ICAM-1	icam-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	LFA-1	lfa-1	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	insufficient	insufficient	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	CD40-mediated	cd40-mediated	JJ	JJ	_	10	amod	_	_
10	up-regulation	up-regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	B7-1	b7-1	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	Fas	fas	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	CD23	cd23	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	Id3	id3	NN	NN	_	6	compound	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	cycle	cycle	NN	NN	_	6	compound	_	_
6	function	function	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	Cdk-2-dependent	cdk-2-dependent	JJ	JJ	_	9	amod	_	_
9	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	functions	function	NNS	NNS	_	25	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	basic	basic	JJ	JJ	_	10	amod	_	_
5	helix-loop-helix	helix-loop-helix	JJ	JJ	_	10	amod	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	bHLH	bhlh	JJ	JJ	_	10	amod	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	2	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	activating	activate	VBG	VBG	_	2	dep	_	_
13	differentiation-linked	differentiation-linked	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	inducing	induce	VBG	VBG	_	12	conj	_	_
19	G1	g1	NN	NN	_	22	compound	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	cycle	cycle	NN	NN	_	22	compound	_	_
22	arrest	arrest	NN	NN	_	18	dobj	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	negatively	negatively	RB	RB	_	25	advmod	_	_
25	regulated	regulate	VBN	VBN	_	0	root	_	_
26	by	by	IN	IN	_	27	case	_	_
27	members	member	NNS	NNS	_	25	nmod	_	_
28	of	of	IN	IN	_	34	case	_	_
29	the	the	DT	DT	_	34	det	_	_
30	Id	id	NN	NN	_	34	compound	_	_
31	family	family	NN	NN	_	34	compound	_	_
32	of	of	IN	IN	_	34	amod	_	_
33	HLH	hlh	JJ	JJ	_	34	amod	_	_
34	proteins	protein	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	bHLH	bhlh	JJ	JJ	_	3	amod	_	_
3	antagonists	antagonist	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	during	during	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	mitogenic	mitogenic	JJ	JJ	_	10	amod	_	_
9	signalling	signalling	NN	NN	_	10	compound	_	_
10	response	response	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	they	they	PRP	PRP	_	14	nsubj	_	_
14	function	function	VBP	VBP	_	5	conj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	sequestering	sequester	VBG	VBG	_	14	advcl	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	bHLH	bhlh	JJ	JJ	_	19	amod	_	_
19	targets	target	NNS	NNS	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	inactive	inactive	JJ	JJ	_	22	amod	_	_
22	heterodimers	heterodimer	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	unable	unable	JJ	JJ	_	22	acl:relcl	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	bind	bind	VB	VB	_	25	xcomp	_	_
28	to	to	TO	TO	_	36	case	_	_
29	specific	specific	JJ	JJ	_	36	amod	_	_
30	gene	gene	NN	NN	_	36	compound	_	_
31	regulatory	regulatory	JJ	JJ	_	36	amod	_	_
32	(	(	-LRB-	-LRB-	_	36	punct	_	_
33	E	e	NN	NN	_	36	compound	_	_
34	box	box	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	sequences	sequence	NNS	NNS	_	27	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	Recently	recently	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	cyclin	cyclin	NN	NN	_	4	compound	_	_
4	E-Cdk2-	e-cdk2-	NN	NN	_	22	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cyclin	cyclin	NN	NN	_	4	conj	_	_
7	A-Cdk2-dependent	a-cdk2-dependent	JJ	JJ	_	6	amod	_	_
8	phosphorylation	phosphorylation	NN	NN	_	4	dep	_	_
9	of	of	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	single	single	JJ	JJ	_	14	amod	_	_
12	conserved	conserve	VBN	VBN	_	14	amod	_	_
13	serine	serine	NN	NN	_	14	compound	_	_
14	residue	residue	NN	NN	_	4	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	Ser5	ser5	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	Id2	id2	NN	NN	_	14	nmod	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	occur	occur	VB	VB	_	22	xcomp	_	_
25	during	during	IN	IN	_	29	case	_	_
26	late	late	JJ	JJ	_	29	amod	_	_
27	G1-to-S	g1-to-s	JJ	JJ	_	29	amod	_	_
28	phase	phase	NN	NN	_	29	compound	_	_
29	transition	transition	NN	NN	_	24	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	cycle	cycle	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	22	punct	_	_
35	and	and	CC	CC	_	22	cc	_	_
36	this	this	DT	DT	_	37	nsubj	_	_
37	neutralizes	neutralize	VBZ	VBZ	_	22	conj	_	_
38	the	the	DT	DT	_	39	det	_	_
39	function	function	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	Id2	id2	NN	NN	_	39	nmod	_	_
42	in	in	IN	IN	_	43	mark	_	_
43	abrogating	abrogate	VBG	VBG	_	39	acl	_	_
44	E-box-dependent	e-box-dependent	JJ	JJ	_	45	amod	_	_
45	bHLH	bhlh	JJ	JJ	_	43	dobj	_	_
46	homo-	homo-	JJ	JJ	_	45	dep	_	_
47	or	or	CC	CC	_	45	cc	_	_
48	heterodimer	heterodimer	NN	NN	_	45	conj	_	_
49	complex	complex	NN	NN	_	50	compound	_	_
50	formation	formation	NN	NN	_	45	dep	_	_
51	in	in	FW	FW	_	52	compound	_	_
52	vitro	vitro	FW	FW	_	50	advmod	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	E.Hara	e.hara	NN	NN	_	22	dep	_	_
55	,	,	,	,	_	54	punct	_	_
56	M.Hall	m.hall	NN	NN	_	54	conj	_	_
57	,	,	,	,	_	54	punct	_	_
58	and	and	CC	CC	_	54	cc	_	_
59	G.Peters	g.peters	NN	NN	_	54	conj	_	_
60	,	,	,	,	_	54	punct	_	_
61	EMBO	EMBO	NNP	NNP	_	62	compound	_	_
62	J.16	J.16	NNP	NNP	_	54	appos	_	_
63	:	:	:	:	_	54	punct	_	_
64	332-342	332-342	CD	CD	_	54	dep	_	_
65	,	,	,	,	_	54	punct	_	_
66	1997	1997	CD	CD	_	54	amod	_	_
67	)	)	-RRB-	-RRB-	_	54	punct	_	_
68	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	an	a	DT	DT	_	8	det	_	_
6	analogous	analogous	JJ	JJ	_	8	amod	_	_
7	cell-cycle-regulated	cell-cycle-regulated	JJ	JJ	_	6	dep	_	_
8	phosphorylation	phosphorylation	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Id3	id3	NN	NN	_	8	nmod	_	_
11	alters	alter	VBZ	VBZ	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	specificity	specificity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Id3	id3	NN	NN	_	13	nmod	_	_
16	for	for	IN	IN	_	17	mark	_	_
17	abrogating	abrogate	VBG	VBG	_	13	acl	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	E-box-dependent	e-box-dependent	JJ	JJ	_	20	amod	_	_
20	bHLH	bhlh	JJ	JJ	_	17	dobj	_	_
21	homo-	homo-	NN	NN	_	20	dep	_	_
22	or	or	CC	CC	_	20	cc	_	_
23	heterodimer	heterodimer	NN	NN	_	20	conj	_	_
24	complex	complex	NN	NN	_	25	compound	_	_
25	formation	formation	NN	NN	_	20	dep	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	25	advmod	_	_
28	and	and	CC	CC	_	20	cc	_	_
29	E-box-dependent	e-box-dependent	JJ	JJ	_	32	amod	_	_
30	reporter	reporter	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	function	function	NN	NN	_	20	conj	_	_
33	in	in	FW	FW	_	34	compound	_	_
34	vivo	vivo	FW	FW	_	32	advmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	compared	compare	VBN	VBN	_	6	case	_	_
4	with	with	IN	IN	_	6	case	_	_
5	wild-type	wild-type	JJ	JJ	_	6	amod	_	_
6	Id3	id3	NN	NN	_	17	advcl	_	_
7	,	,	,	,	_	17	punct	_	_
8	an	a	DT	DT	_	11	det	_	_
9	Id3	id3	NN	NN	_	11	compound	_	_
10	Asp5	asp5	NN	NN	_	11	compound	_	_
11	mutant	mutant	NN	NN	_	17	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	mimicking	mimic	VBG	VBG	_	11	dep	_	_
14	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
15	)	)	-RRB-	-RRB-	_	13	punct	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	unable	unable	JJ	JJ	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	promote	promote	VB	VB	_	17	xcomp	_	_
20	cell	cell	NN	NN	_	24	compound	_	_
21	cycle	cycle	NN	NN	_	24	compound	_	_
22	S	s	NN	NN	_	24	compound	_	_
23	phase	phase	NN	NN	_	24	compound	_	_
24	entry	entry	NN	NN	_	19	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	transfected	transfect	VBN	VBN	_	27	amod	_	_
27	fibroblasts	fibroblast	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	whereas	whereas	IN	IN	_	38	mark	_	_
30	an	a	DT	DT	_	33	det	_	_
31	Id3	id3	NN	NN	_	33	compound	_	_
32	Ala5	ala5	NN	NN	_	33	compound	_	_
33	mutant	mutant	NN	NN	_	38	nsubj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	ablating	ablate	VBG	VBG	_	33	dep	_	_
36	phosphorylation	phosphorylation	NN	NN	_	35	dobj	_	_
37	)	)	-RRB-	-RRB-	_	35	punct	_	_
38	displays	display	VBZ	VBZ	_	17	advcl	_	_
39	an	a	DT	DT	_	40	det	_	_
40	activity	activity	NN	NN	_	38	dobj	_	_
41	significantly	significantly	RB	RB	_	42	advmod	_	_
42	greater	greater	JJR	JJR	_	40	amod	_	_
43	than	than	IN	IN	_	44	case	_	_
44	that	that	DT	DT	_	42	nmod	_	_
45	of	of	IN	IN	_	48	case	_	_
46	wild-type	wild-type	JJ	JJ	_	48	amod	_	_
47	Id3	id3	NN	NN	_	48	compound	_	_
48	protein	protein	NN	NN	_	44	nmod	_	_
49	.	.	.	.	_	17	punct	_	_

1	Cdk2-dependent	cdk2-dependent	JJ	JJ	_	2	amod	_	_
2	phosphorylation	phosphorylation	NN	NN	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	provides	provide	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	switch	switch	NN	NN	_	4	dobj	_	_
7	during	during	IN	IN	_	10	case	_	_
8	late	late	JJ	JJ	_	10	amod	_	_
9	G1-to-S	g1-to-s	JJ	JJ	_	10	amod	_	_
10	phase	phase	NN	NN	_	6	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	nullifies	nullify	VBZ	VBZ	_	6	acl:relcl	_	_
14	an	a	DT	DT	_	20	det	_	_
15	early	early	JJ	JJ	_	20	amod	_	_
16	G1	g1	NN	NN	_	20	compound	_	_
17	cell	cell	NN	NN	_	20	compound	_	_
18	cycle	cycle	NN	NN	_	20	compound	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	function	function	NN	NN	_	13	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	Id3	id3	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	modulates	modulate	VBZ	VBZ	_	13	conj	_	_
25	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
26	target	target	NN	NN	_	28	compound	_	_
27	bHLH	bhlh	JJ	JJ	_	28	compound	_	_
28	specificity	specificity	NN	NN	_	24	dobj	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	21	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	ability	ability	NN	NN	_	21	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Id3	id3	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	promote	promote	VB	VB	_	7	acl	_	_
12	cell	cell	NN	NN	_	16	compound	_	_
13	cycle	cycle	NN	NN	_	16	compound	_	_
14	S	s	NN	NN	_	16	compound	_	_
15	phase	phase	NN	NN	_	16	compound	_	_
16	entry	entry	NN	NN	_	11	dobj	_	_
17	is	be	VBZ	VBZ	_	21	cop	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	simply	simply	RB	RB	_	21	advmod	_	_
20	a	a	DT	DT	_	21	det	_	_
21	function	function	NN	NN	_	4	ccomp	_	_
22	of	of	IN	IN	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	ability	ability	NN	NN	_	21	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	modulate	modulate	VB	VB	_	24	acl	_	_
27	bHLH	bhlh	JJ	JJ	_	30	compound	_	_
28	heterodimer-dependent	heterodimer-dependent	JJ	JJ	_	30	amod	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	26	dobj	_	_
31	and	and	CC	CC	_	4	cc	_	_
32	establish	establish	VB	VB	_	4	conj	_	_
33	a	a	DT	DT	_	36	det	_	_
34	biologically	biologically	RB	RB	_	35	advmod	_	_
35	important	important	JJ	JJ	_	36	amod	_	_
36	mechanism	mechanism	NN	NN	_	32	dobj	_	_
37	through	through	IN	IN	_	38	case	_	_
38	which	which	WDT	WDT	_	44	nmod	_	_
39	Cdk2	cdk2	NN	NN	_	44	nsubjpass	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	Id-bHLH	id-bhlh	JJ	JJ	_	39	conj	_	_
42	functions	function	NNS	NNS	_	39	dep	_	_
43	are	be	VBP	VBP	_	44	auxpass	_	_
44	integrated	integrate	VBN	VBN	_	36	acl:relcl	_	_
45	in	in	IN	IN	_	47	case	_	_
46	the	the	DT	DT	_	47	det	_	_
47	coordination	coordination	NN	NN	_	44	nmod	_	_
48	of	of	IN	IN	_	49	case	_	_
49	cell	cell	NN	NN	_	47	nmod	_	_
50	proliferation	proliferation	NN	NN	_	49	dep	_	_
51	and	and	CC	CC	_	49	cc	_	_
52	differentiation	differentiation	NN	NN	_	49	conj	_	_
53	.	.	.	.	_	4	punct	_	_

1	Hypoxia	hypoxia	NN	NN	_	2	nsubj	_	_
2	enhances	enhance	VBZ	VBZ	_	0	root	_	_
3	induction	induction	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	endothelial	endothelial	JJ	JJ	_	6	amod	_	_
6	ICAM-1	icam-1	NN	NN	_	3	nmod	_	_
7	:	:	:	:	_	2	punct	_	_
8	role	role	NN	NN	_	2	dep	_	_
9	for	for	IN	IN	_	11	case	_	_
10	metabolic	metabolic	JJ	JJ	_	11	amod	_	_
11	acidosis	acidosis	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	proteasomes	proteasome	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	Intercellular	intercellular	JJ	JJ	_	3	amod	_	_
2	adhesion	adhesion	NN	NN	_	3	compound	_	_
3	molecule	molecule	NN	NN	_	11	nsubj	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	ICAM-1	icam-1	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	molecule	molecule	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	promotion	promotion	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	polymorphonuclear	polymorphonuclear	JJ	JJ	_	18	amod	_	_
16	neutrophil	neutrophil	NN	NN	_	18	compound	_	_
17	transendothelial	transendothelial	JJ	JJ	_	18	amod	_	_
18	migration	migration	NN	NN	_	13	nmod	_	_
19	during	during	IN	IN	_	20	case	_	_
20	inflammation	inflammation	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Coincident	coincident	JJ	JJ	_	6	dep	_	_
2	with	with	IN	IN	_	5	case	_	_
3	many	many	JJ	JJ	_	5	amod	_	_
4	inflammatory	inflammatory	JJ	JJ	_	5	amod	_	_
5	diseases	disease	NNS	NNS	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	tissue	tissue	NN	NN	_	8	compound	_	_
8	hypoxia	hypoxia	NN	NN	_	6	nsubj	_	_
9	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	combinations	combination	NNS	NNS	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	hypoxia	hypoxia	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
10	stimuli	stimulus	NNS	NNS	_	7	conj	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	differentially	differentially	RB	RB	_	13	advmod	_	_
13	regulate	regulate	VB	VB	_	3	ccomp	_	_
14	expression	expression	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	endothelial	endothelial	JJ	JJ	_	17	amod	_	_
17	ICAM-1	icam-1	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	endothelial	endothelial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	exposed	expose	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	hypoxia	hypoxia	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	dep	_	_
10	presence	presence	NN	NN	_	5	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	absence	absence	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	added	add	VBN	VBN	_	15	amod	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LPS	lps	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	examined	examine	VBN	VBN	_	5	conj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	expression	expression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	functional	functional	JJ	JJ	_	25	amod	_	_
25	ICAM-1	icam-1	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	hypoxia	hypoxia	NN	NN	_	6	nsubj	_	_
3	alone	alone	RB	RB	_	2	advmod	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	induce	induce	VB	VB	_	15	advcl	_	_
7	ICAM-1	icam-1	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	15	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	combination	combination	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	LPS	lps	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	hypoxia	hypoxia	NN	NN	_	12	conj	_	_
15	enhanced	enhance	VBD	VBD	_	0	root	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	3	3	CD	CD	_	15	dep	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	0.4-fold	0.4-fold	JJ	JJ	_	17	conj	_	_
20	over	over	IN	IN	_	17	case	_	_
21	normoxia	normoxia	NN	NN	_	17	dep	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	ICAM-1	icam-1	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	15	dobj	_	_
25	.	.	.	.	_	15	punct	_	_

1	Combinations	combination	NNS	NNS	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	hypoxia	hypoxia	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	LPS	lps	NN	NN	_	3	conj	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	increased	increase	VBD	VBD	_	0	root	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	such	such	JJ	JJ	_	13	amod	_	_
13	increases	increase	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	inhibited	inhibit	VBN	VBN	_	7	conj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	addition	addition	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	anti-ICAM-1	anti-icam-1	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	17	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	antisense	antisense	JJ	JJ	_	23	amod	_	_
23	oligonucleotides	oligonucleotide	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	Hypoxic	hypoxic	JJ	JJ	_	2	amod	_	_
2	endothelia	endothelia	NN	NN	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	&gt;	&gt;	JJR	JJR	_	6	dep	_	_
6	10-fold	10-fold	JJ	JJ	_	7	amod	_	_
7	increase	increase	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	sensitivity	sensitivity	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	inhibitors	inhibitor	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	proteasome	proteasome	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	combinations	combination	NNS	NNS	_	22	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	hypoxia	hypoxia	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	LPS	lps	NN	NN	_	19	conj	_	_
22	enhanced	enhance	VBD	VBD	_	3	conj	_	_
23	proteasome-dependent	proteasome-dependent	JJ	JJ	_	25	amod	_	_
24	cytoplasmic-to-nuclear	cytoplasmic-to-nuclear	JJ	JJ	_	25	amod	_	_
25	localization	localization	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	37	case	_	_
27	the	the	DT	DT	_	37	det	_	_
28	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
29	transcription	transcription	NN	NN	_	37	compound	_	_
30	factor-kappa	factor-kappa	NN	NN	_	37	compound	_	_
31	B	b	NN	NN	_	37	compound	_	_
32	p65	p65	NN	NN	_	37	compound	_	_
33	(	(	-LRB-	-LRB-	_	37	punct	_	_
34	Rel	rel	NN	NN	_	37	compound	_	_
35	A	a	NN	NN	_	37	compound	_	_
36	)	)	-RRB-	-RRB-	_	37	punct	_	_
37	subunit	subunit	NN	NN	_	25	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	proteasome	proteasome	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	correlated	correlate	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	hypoxia-evoked	hypoxia-evoked	JJ	JJ	_	7	amod	_	_
7	decreases	decrease	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	extracellular	extracellular	JJ	JJ	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	intracellular	intracellular	JJ	JJ	_	10	conj	_	_
13	pH	ph	NN	NN	_	10	dep	_	_
14	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	hypoxia	hypoxia	NN	NN	_	9	nsubj	_	_
9	provides	provide	VBZ	VBZ	_	2	ccomp	_	_
10	a	a	DT	DT	_	14	det	_	_
11	novel	novel	JJ	JJ	_	14	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	proteasome-dependent	proteasome-dependent	JJ	JJ	_	11	dep	_	_
14	stimulus	stimulus	NN	NN	_	9	dobj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	ICAM-1	icam-1	NN	NN	_	17	compound	_	_
17	induction	induction	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Phosphatidylinositol	phosphatidylinositol	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	3	nsubj	_	_
3	couples	couple	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	cycle	cycle	NN	NN	_	11	compound	_	_
11	regulator	regulator	NN	NN	_	3	nmod	_	_
12	E2F	e2f	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	3	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	cycle	cycle	NN	NN	_	3	compound	_	_
3	progression	progression	NN	NN	_	14	nsubj	_	_
4	initiated	initiate	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	interleukin-2	interleukin-2	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-2	il-2	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	critical	critical	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	16	case	_	_
16	lymphoproliferation	lymphoproliferation	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	an	a	DT	DT	_	20	det	_	_
19	immune	immune	JJ	JJ	_	20	amod	_	_
20	response	response	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	14	punct	_	_

1	Phosphatidyl	phosphatidyl	NN	NN	_	3	compound	_	_
2	inositol	inositol	NN	NN	_	3	compound	_	_
3	3-kinase	3-kinase	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PI3K	pi3k	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-2	il-2	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	targets	target	NNS	NNS	_	9	nsubjpass	_	_
5	for	for	IN	IN	_	6	case	_	_
6	PI3K	pi3k	NN	NN	_	4	nmod	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	known	know	VBN	VBN	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	cycle	cycle	NN	NN	_	7	compound	_	_
7	regulator	regulator	NN	NN	_	3	dobj	_	_
8	E2F	e2f	NN	NN	_	7	dep	_	_
9	as	as	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	target	target	NN	NN	_	3	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	T	t	NN	NN	_	12	nmod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	14	dep	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	PI3K	pi3k	NN	NN	_	3	conj	_	_
18	as	as	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	critical	critical	JJ	JJ	_	22	amod	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	eliminate	eliminate	VBP	VBP	_	0	root	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	Stat5	stat5	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Raf/MEK	raf/mek	NN	NN	_	4	conj	_	_
7	pathways	pathway	NNS	NNS	_	4	dep	_	_
8	from	from	IN	IN	_	10	case	_	_
9	E2F	e2f	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PKB	pkb	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-2	il-2	NN	NN	_	8	nmod	_	_
11	via	via	IN	IN	_	12	case	_	_
12	PI3K	pi3k	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	active	active	JJ	JJ	_	6	amod	_	_
6	PKB	pkb	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	sufficient	sufficient	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	induce	induce	VB	VB	_	8	xcomp	_	_
11	E2F	e2f	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PI3K	pi3k	NN	NN	_	1	nmod	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Rb	rb	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	induction	induction	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cyclin	cyclin	NN	NN	_	12	compound	_	_
12	D3	d3	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	degradation	degradation	NN	NN	_	5	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	p27kip1	p27kip1	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	crucial	crucial	JJ	JJ	_	7	amod	_	_
6	PI3K/PKB-mediated	pi3k/pkb-mediated	JJ	JJ	_	7	amod	_	_
7	link	link	NN	NN	_	3	dobj	_	_
8	between	between	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	teceptor	teceptor	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	16	det	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	cycle	cycle	NN	NN	_	16	compound	_	_
16	machinery	machinery	NN	NN	_	11	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Thiol	thiol	NN	NN	_	2	compound	_	_
2	modulation	modulation	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	10	det	_	_
5	interleukin	interleukin	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	IL	il	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	-1-mediated	-1-mediated	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	3	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	an	a	DT	DT	_	16	det	_	_
13	IL-1	il-1	NN	NN	_	16	compound	_	_
14	receptor-associated	receptor-associated	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	kinase	kinase	NN	NN	_	10	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	interleukin-1	interleukin-1	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	type	type	NN	NN	_	10	nsubjpass	_	_
5	I	i	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-1RI	il-1ri	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	10	nmod	_	_
14	thus	thus	RB	RB	_	15	advmod	_	_
15	forming	form	VBG	VBG	_	10	xcomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	complex	complex	JJ	JJ	_	18	amod	_	_
18	system	system	NN	NN	_	15	dobj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	22	nmod	_	_
21	IL-1	il-1	NN	NN	_	22	nsubj	_	_
22	exerts	exert	VBZ	VBZ	_	18	acl:relcl	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	various	various	JJ	JJ	_	25	amod	_	_
25	signals	signal	NNS	NNS	_	22	dobj	_	_
26	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	initiating	initiate	VBG	VBG	_	3	amod	_	_
3	event	event	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	still	still	RB	RB	_	6	advmod	_	_
6	uncertain	uncertain	JJ	JJ	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	6	cc	_	_
9	activation	activation	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	a	a	DT	DT	_	16	det	_	_
12	recently	recently	RB	RB	_	13	advmod	_	_
13	described	describe	VBN	VBN	_	16	amod	_	_
14	receptor-associated	receptor-associated	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	kinase	kinase	NN	NN	_	9	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	one	one	CD	CD	_	6	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	earliest	earliest	JJS	JJS	_	22	amod	_	_
22	events	event	NNS	NNS	_	18	nmod	_	_
23	detectable	detectable	JJ	JJ	_	22	amod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	Martin	Martin	NNP	NNP	_	6	dep	_	_
26	et	et	FW	FW	_	25	compound	_	_
27	al.	al.	FW	FW	_	25	dep	_	_
28	,	,	,	,	_	25	punct	_	_
29	Eur.J.Immunol.1994.24	eur.j.immunol.1994.24	NN	NN	_	25	appos	_	_
30	:	:	:	:	_	25	punct	_	_
31	1566	1566	CD	CD	_	25	dep	_	_
32	)	)	-RRB-	-RRB-	_	25	punct	_	_
33	.	.	.	.	_	6	punct	_	_

1	IL-1	il-1	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	commonly	commonly	RB	RB	_	5	advmod	_	_
5	accompanied	accompany	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	oxidative	oxidative	JJ	JJ	_	8	amod	_	_
8	processes	process	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	thought	think	VBN	VBN	_	5	conj	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	subject	subject	JJ	JJ	_	11	xcomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	redox	redox	NN	NN	_	17	compound	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	whether	whether	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	IL-1RI-associated	il-1ri-associated	JJ	JJ	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	6	nmod	_	_
12	could	could	MD	MD	_	15	aux	_	_
13	be	be	VB	VB	_	15	cop	_	_
14	a	a	DT	DT	_	15	det	_	_
15	target	target	NN	NN	_	3	ccomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	redox	redox	NN	NN	_	18	compound	_	_
18	regulation	regulation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	whether	whether	IN	IN	_	28	mark	_	_
21	an	a	DT	DT	_	23	det	_	_
22	altered	altered	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	28	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	kinase	kinase	NN	NN	_	23	nmod	_	_
27	could	could	MD	MD	_	28	aux	_	_
28	influence	influence	VB	VB	_	15	conj	_	_
29	IL-1-mediated	il-1-mediated	JJ	JJ	_	32	amod	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	28	dobj	_	_
33	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	murine	murine	JJ	JJ	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	10	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	EL4	el4	NN	NN	_	5	appos	_	_
8	,	,	,	,	_	5	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	stimulated	stimulate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	IL-1	il-1	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	16	nmod	_	_
14	and	and	CC	CC	_	16	cc	_	_
15	without	without	IN	IN	_	16	conj	_	_
16	pretreatment	pretreatment	NN	NN	_	10	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	compounds	compound	NNS	NNS	_	16	nmod	_	_
20	known	know	VBN	VBN	_	19	acl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	influence	influence	VB	VB	_	20	xcomp	_	_
23	the	the	DT	DT	_	26	det	_	_
24	cellular	cellular	JJ	JJ	_	26	amod	_	_
25	redox	redox	NN	NN	_	26	compound	_	_
26	status	status	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	Thiol	thiol	NN	NN	_	3	compound	_	_
2	modifying	modifying	NN	NN	_	3	compound	_	_
3	agents	agent	NNS	NNS	_	20	nsubj	_	_
4	like	like	IN	IN	_	5	case	_	_
5	diamide	diamide	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	menadione	menadione	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	pyrrolidine	pyrrolidine	NN	NN	_	10	compound	_	_
10	dithiocarbamate	dithiocarbamate	NN	NN	_	5	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PDTC	pdtc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	5	punct	_	_
15	diethyl	diethyl	NN	NN	_	16	compound	_	_
16	dithiocarbamate	dithiocarbamate	NN	NN	_	5	conj	_	_
17	or	or	CC	CC	_	5	cc	_	_
18	phenylarsine	phenylarsine	NN	NN	_	19	compound	_	_
19	oxide	oxide	NN	NN	_	5	conj	_	_
20	inhibited	inhibit	VBD	VBD	_	0	root	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-1-induced	il-1-induced	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	IL-1RI-associated	il-1ri-associated	JJ	JJ	_	28	amod	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	kinase	kinase	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	N-Acetylcysteine	n-acetylcysteine	NN	NN	_	10	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	alpha,alpha'-dipyridyl	alpha,alpha'-dipyridyl	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	aminotriazole	aminotriazole	NN	NN	_	1	conj	_	_
6	or	or	CC	CC	_	1	cc	_	_
7	nitrofurantoin	nitrofurantoin	NN	NN	_	1	conj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	show	show	VB	VB	_	0	root	_	_
11	any	any	DT	DT	_	12	det	_	_
12	effect	effect	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	6	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	PDTC	pdtc	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	reversible	reversible	JJ	JJ	_	0	root	_	_
7	unless	unless	IN	IN	_	11	mark	_	_
8	glutathione	glutathione	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	blocked	block	VBN	VBN	_	6	advcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	buthionine	buthionine	NN	NN	_	14	compound	_	_
14	sulfoximine	sulfoximine	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	described	describe	VBN	VBN	_	3	amod	_	_
3	conditions	condition	NNS	NNS	_	15	nsubj	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	3	acl:relcl	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	prevented	prevent	VBD	VBD	_	5	conj	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-1RI-associated	il-1ri-associated	JJ	JJ	_	13	amod	_	_
13	kinase	kinase	NN	NN	_	9	nmod	_	_
14	similarly	similarly	RB	RB	_	15	advmod	_	_
15	impaired	impair	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	EL4	el4	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	observations	observation	NNS	NNS	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	conclude	conclude	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	free	free	JJ	JJ	_	8	amod	_	_
8	thiols	thiol	NNS	NNS	_	14	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-1RI	il-1ri	NN	NN	_	12	compound	_	_
12	complex	complex	NN	NN	_	8	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	essential	essential	JJ	JJ	_	5	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	IL-1RI-associated	il-1ri-associated	JJ	JJ	_	22	amod	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	kinase	kinase	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	14	cc	_	_
24	that	that	IN	IN	_	28	mark	_	_
25	this	this	DT	DT	_	26	det	_	_
26	process	process	NN	NN	_	28	nsubj	_	_
27	is	be	VBZ	VBZ	_	28	cop	_	_
28	mandatory	mandatory	JJ	JJ	_	14	conj	_	_
29	for	for	IN	IN	_	31	case	_	_
30	IL-1	il-1	NN	NN	_	31	compound	_	_
31	signaling	signaling	NN	NN	_	28	nmod	_	_
32	leading	lead	VBG	VBG	_	31	acl	_	_
33	to	to	TO	TO	_	36	case	_	_
34	NF-kappa	nf-kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	ATF1	atf1	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CREB	creb	NN	NN	_	1	conj	_	_
4	trans-activate	trans-activate	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	11	det	_	_
6	cell	cell	NN	NN	_	11	compound	_	_
7	cycle	cycle	NN	NN	_	11	compound	_	_
8	regulated	regulated	JJ	JJ	_	11	amod	_	_
9	histone	histone	NN	NN	_	11	compound	_	_
10	H4	h4	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	4	dobj	_	_
12	at	at	IN	IN	_	19	case	_	_
13	a	a	DT	DT	_	19	det	_	_
14	distal	distal	JJ	JJ	_	19	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
16	matrix	matrix	NN	NN	_	19	compound	_	_
17	associated	associated	JJ	JJ	_	19	amod	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	element	element	NN	NN	_	4	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Proteins	protein	NNS	NNS	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	ATF/CREB	atf/creb	NN	NN	_	5	compound	_	_
5	class	class	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	stimulate	stimulate	VBP	VBP	_	0	root	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	several	several	JJ	JJ	_	16	amod	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	growth-related	growth-related	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	11	nmod	_	_
17	through	through	IN	IN	_	23	case	_	_
18	protein	protein	NN	NN	_	23	compound	_	_
19	kinase	kinase	NN	NN	_	23	compound	_	_
20	A-related	a-related	JJ	JJ	_	23	amod	_	_
21	cAMP	camp	NN	NN	_	23	compound	_	_
22	response	response	NN	NN	_	23	compound	_	_
23	elements	element	NNS	NNS	_	9	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	cell	cell	NN	NN	_	10	compound	_	_
6	cycle	cycle	NN	NN	_	10	compound	_	_
7	regulated	regulated	JJ	JJ	_	10	amod	_	_
8	histone	histone	NN	NN	_	10	compound	_	_
9	H4	h4	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	3	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	19	case	_	_
14	at	at	IN	IN	_	15	case	_	_
15	least	least	JJS	JJS	_	16	nmod:npmod	_	_
16	four	four	CD	CD	_	19	nummod	_	_
17	principal	principal	JJ	JJ	_	19	amod	_	_
18	cis-acting	cis-act	VBG	VBG	_	19	amod	_	_
19	elements	element	NNS	NNS	_	12	nmod	_	_
20	which	which	WDT	WDT	_	21	nsubj	_	_
21	mediate	mediate	VBP	VBP	_	19	acl:relcl	_	_
22	G1/S	g1/s	NN	NN	_	24	compound	_	_
23	phase	phase	NN	NN	_	24	compound	_	_
24	control	control	NN	NN	_	21	dobj	_	_
25	and/or	and/or	CC	CC	_	24	cc	_	_
26	enhancement	enhancement	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	transcription	transcription	NN	NN	_	26	nmod	_	_
29	during	during	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	cycle	cycle	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	protein-DNA	protein-dna	JJ	JJ	_	4	amod	_	_
3	interaction	interaction	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	1	dobj	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	H4	h4	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	11	nsubj	_	_
11	contains	contain	VBZ	VBZ	_	6	ccomp	_	_
12	two	two	CD	CD	_	15	nummod	_	_
13	ATF/CREB	atf/creb	NN	NN	_	15	compound	_	_
14	recognition	recognition	NN	NN	_	15	compound	_	_
15	motifs	motif	NNS	NNS	_	11	dobj	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	interact	interact	VBP	VBP	_	15	acl:relcl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	CREB	creb	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	ATF1	atf1	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	ATF2	atf2	NN	NN	_	19	conj	_	_
25	but	but	CC	CC	_	19	cc	_	_
26	not	not	RB	RB	_	28	neg	_	_
27	with	with	IN	IN	_	28	case	_	_
28	ATF4/CREB2	atf4/creb2	NN	NN	_	19	conj	_	_
29	.	.	.	.	_	1	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	ATF/CRE	atf/cre	NN	NN	_	3	compound	_	_
3	motif	motif	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	located	located	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	distal	distal	JJ	JJ	_	9	amod	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	at	at	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	matrix-associated	matrix-associated	JJ	JJ	_	14	amod	_	_
14	Site	site	NN	NN	_	9	nmod	_	_
15	IV	iv	CD	CD	_	14	nummod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	second	second	JJ	JJ	_	20	amod	_	_
20	motif	motif	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	present	present	JJ	JJ	_	5	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	proximal	proximal	JJ	JJ	_	26	amod	_	_
26	promoter	promoter	NN	NN	_	22	nmod	_	_
27	at	at	IN	IN	_	28	case	_	_
28	Site	site	NN	NN	_	26	nmod	_	_
29	I	i	CD	CD	_	28	nummod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Both	both	DT	DT	_	3	dep	_	_
2	ATF/CRE	atf/cre	NN	NN	_	3	compound	_	_
3	motifs	motif	NNS	NNS	_	4	nsubj	_	_
4	overlap	overlap	VBP	VBP	_	0	root	_	_
5	binding	bind	VBG	VBG	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	4	dobj	_	_
7	for	for	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	multifunctional	multifunctional	JJ	JJ	_	12	amod	_	_
10	YY1	yy1	NN	NN	_	12	compound	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	18	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	18	aux	_	_
16	previously	previously	RB	RB	_	18	advmod	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	shown	show	VBN	VBN	_	12	acl:relcl	_	_
19	to	to	TO	TO	_	23	mark	_	_
20	be	be	VB	VB	_	23	cop	_	_
21	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
22	matrix	matrix	NN	NN	_	23	nmod:npmod	_	_
23	associated	associated	JJ	JJ	_	18	xcomp	_	_
24	.	.	.	.	_	4	punct	_	_

1	Subnuclear	subnuclear	JJ	JJ	_	2	amod	_	_
2	fractionation	fractionation	NN	NN	_	3	nsubj	_	_
3	reveals	reveal	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	are	be	VBP	VBP	_	3	ccomp	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	ATF1	atf1	NN	NN	_	9	compound	_	_
9	isoforms	isoform	NNS	NNS	_	6	nsubj	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	appear	appear	VBP	VBP	_	9	acl:relcl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	differ	differ	VB	VB	_	11	xcomp	_	_
14	with	with	IN	IN	_	15	case	_	_
15	respect	respect	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	DNA	dna	NN	NN	_	15	nmod	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	17	dep	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	partition	partition	NN	NN	_	17	conj	_	_
22	selectively	selectively	RB	RB	_	13	advmod	_	_
23	between	between	IN	IN	_	25	case	_	_
24	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
25	matrix	matrix	NN	NN	_	13	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	nonmatrix	nonmatrix	JJ	JJ	_	25	conj	_	_
28	compartments	compartment	NNS	NNS	_	25	dep	_	_
29	,	,	,	,	_	13	punct	_	_
30	consistent	consistent	JJ	JJ	_	13	advmod	_	_
31	with	with	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	role	role	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	nuclear	nuclear	JJ	JJ	_	37	amod	_	_
37	matrix	matrix	NN	NN	_	33	nmod	_	_
38	in	in	IN	IN	_	39	mark	_	_
39	regulating	regulate	VBG	VBG	_	33	acl	_	_
40	gene	gene	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	39	dobj	_	_
42	.	.	.	.	_	3	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	3	amod	_	_
2	mutational	mutational	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	Site	site	NN	NN	_	12	nsubj	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	Site	site	NN	NN	_	6	conj	_	_
10	IV	iv	CD	CD	_	9	nummod	_	_
11	together	together	RB	RB	_	12	advmod	_	_
12	support	support	VBP	VBP	_	4	ccomp	_	_
13	ATF1-	atf1-	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	CREB-induced	creb-induced	JJ	JJ	_	13	conj	_	_
16	trans-activation	trans-activation	NN	NN	_	13	dep	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	H4	h4	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	establish	establish	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	ATF/CREB	atf/creb	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	10	nsubj	_	_
9	functionally	functionally	RB	RB	_	10	advmod	_	_
10	modulate	modulate	VBP	VBP	_	5	ccomp	_	_
11	histone	histone	NN	NN	_	13	compound	_	_
12	H4	h4	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	10	dobj	_	_
15	at	at	IN	IN	_	16	case	_	_
16	distal	distal	JJ	JJ	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	proximal	proximal	JJ	JJ	_	16	conj	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	16	dep	_	_
21	.	.	.	.	_	5	punct	_	_

1	IL-2	il-2	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-7	il-7	NN	NN	_	1	conj	_	_
4	induce	induce	VBP	VBP	_	0	root	_	_
5	heterodimerization	heterodimerization	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT5	stat5	NN	NN	_	8	compound	_	_
8	isoforms	isoform	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphoblasts	lymphoblast	NNS	NNS	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Despite	despite	IN	IN	_	2	case	_	_
2	differences	difference	NNS	NNS	_	19	nmod	_	_
3	in	in	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	responses	response	NNS	NNS	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	interleukin	interleukin	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL	il	NN	NN	_	7	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	-2	-2	CD	CD	_	11	nummod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	IL-7	il-7	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	19	punct	_	_
17	both	both	DT	DT	_	18	dep	_	_
18	cytokines	cytokine	NNS	NNS	_	19	nsubj	_	_
19	modulate	modulate	VBP	VBP	_	0	root	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	functions	function	NNS	NNS	_	19	dobj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	activation	activation	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	signal	signal	NN	NN	_	27	compound	_	_
27	transducers	transducer	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	activators	activator	NNS	NNS	_	35	compound	_	_
30	of	of	IN	IN	_	35	amod	_	_
31	transcription	transcription	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	STAT	stat	NN	NN	_	35	compound	_	_
34	)	)	-RRB-	-RRB-	_	35	punct	_	_
35	proteins	protein	NNS	NNS	_	27	conj	_	_
36	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	contribution	contribution	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	isoforms	isoform	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT5	stat5	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	STAT5A	stat5a	NN	NN	_	8	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	STAT5B	stat5b	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	4	punct	_	_
16	to	to	TO	TO	_	17	case	_	_
17	IL-2-	il-2-	NN	NN	_	4	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-7-induced	il-7-induced	JJ	JJ	_	17	conj	_	_
20	activation	activation	NN	NN	_	17	dep	_	_
21	of	of	IN	IN	_	26	case	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	lymphoblasts	lymphoblast	NNS	NNS	_	17	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	dep	_	_
2	cytokines	cytokine	NNS	NNS	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	assembly	assembly	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STAT5A	stat5a	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	STAT5B	stat5b	NN	NN	_	6	conj	_	_
9	containing	contain	VBG	VBG	_	4	acl	_	_
10	complexes	complex	NNS	NNS	_	9	dobj	_	_
11	capable	capable	JJ	JJ	_	10	amod	_	_
12	of	of	IN	IN	_	13	mark	_	_
13	binding	bind	VBG	VBG	_	11	advcl	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	interferon-gamma	interferon-gamma	NN	NN	_	18	compound	_	_
17	activation	activation	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GAS	gas	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	3	punct	_	_
23	and	and	CC	CC	_	3	cc	_	_
24	these	these	DT	DT	_	25	det	_	_
25	complexes	complex	NNS	NNS	_	27	nsubj	_	_
26	rapidly	rapidly	RB	RB	_	27	advmod	_	_
27	translocated	translocate	VBD	VBD	_	3	conj	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	within	within	IN	IN	_	31	case	_	_
30	1	1	CD	CD	_	31	nummod	_	_
31	min	min	NN	NN	_	27	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	into	into	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	nucleus	nucleus	NN	NN	_	27	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	IL-2-	il-2-	NN	NN	_	35	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	IL-7-treated	il-7-treated	JJ	JJ	_	37	conj	_	_
40	cells	cell	NNS	NNS	_	37	dep	_	_
41	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	translocation	translocation	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	delayed	delay	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	IL-7-treated	il-7-treated	JJ	JJ	_	7	nmod	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	compared	compare	VBN	VBN	_	7	advcl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	IL-2-treated	il-2-treated	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	IL-2	il-2	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-7	il-7	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	equivalent	equivalent	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
8	ability	ability	NN	NN	_	5	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	induce	induce	VB	VB	_	8	dep	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	STAT5A	stat5a	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	STAT5B	stat5b	NN	NN	_	14	conj	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	facilitate	facilitate	VB	VB	_	10	conj	_	_
20	binding	binding	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	STATs	stats	NNS	NNS	_	20	nmod	_	_
24	to	to	TO	TO	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	immobilized	immobilize	VBN	VBN	_	28	amod	_	_
27	GAS	gas	NN	NN	_	28	compound	_	_
28	element	element	NN	NN	_	20	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	IL-2	il-2	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IL-7	il-7	NN	NN	_	2	conj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	substantial	substantial	JJ	JJ	_	7	amod	_	_
7	amounts	amount	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	STAT5A/STAT5B	stat5a/stat5b	NN	NN	_	10	compound	_	_
10	heterodimerization	heterodimerization	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observed	observe	VBD	VBD	_	0	root	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	association	association	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT3	stat3	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	each	each	DT	DT	_	12	det	_	_
11	STAT5	stat5	NN	NN	_	12	compound	_	_
12	isomer	isomer	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	IL-2	il-2	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-7	il-7	NN	NN	_	5	conj	_	_
8	induce	induce	VBP	VBP	_	3	ccomp	_	_
9	assembly	assembly	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	STAT	stat	NN	NN	_	12	compound	_	_
12	heterodimers	heterodimer	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	similar	similar	JJ	JJ	_	16	amod	_	_
16	manner	manner	NN	NN	_	8	nmod	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	that	that	IN	IN	_	24	mark	_	_
19	subsequent	subsequent	JJ	JJ	_	21	amod	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	responses	response	NNS	NNS	_	24	nsubjpass	_	_
22	may	may	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	driven	drive	VBN	VBN	_	8	conj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	induction	induction	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	similar	similar	JJ	JJ	_	29	amod	_	_
29	sets	set	NNS	NNS	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	genes	gene	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Selection	selection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	diverse	diverse	JJ	JJ	_	6	amod	_	_
5	TCR	tcr	NN	NN	_	6	compound	_	_
6	repertoire	repertoire	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	response	response	NN	NN	_	1	nmod	_	_
9	to	to	TO	TO	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
12	virus-encoded	virus-encoded	JJ	JJ	_	14	amod	_	_
13	transactivator	transactivator	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	8	nmod	_	_
15	BZLF1	bzlf1	NN	NN	_	14	dep	_	_
16	by	by	IN	IN	_	20	case	_	_
17	CD8+	cd8+	JJ	JJ	_	20	amod	_	_
18	cytotoxic	cytotoxic	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
21	during	during	IN	IN	_	22	case	_	_
22	primary	primary	JJ	JJ	_	1	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	persistent	persistent	JJ	JJ	_	22	conj	_	_
25	infection	infection	NN	NN	_	22	dep	_	_
26	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	11	det	_	_
4	CD8+	cd8+	JJ	JJ	_	11	amod	_	_
5	cytotoxic	cytotoxic	JJ	JJ	_	11	amod	_	_
6	T	t	NN	NN	_	11	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	CTL	ctl	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	repertoire	repertoire	NN	NN	_	2	dobj	_	_
12	to	to	TO	TO	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	HLA	hla	NN	NN	_	16	compound	_	_
15	B8-restricted	b8-restricted	JJ	JJ	_	16	amod	_	_
16	peptide	peptide	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	RAKFKQLLQ	rakfkqllq	NN	NN	_	16	appos	_	_
19	,	,	,	,	_	16	punct	_	_
20	located	located	JJ	JJ	_	16	amod	_	_
21	in	in	IN	IN	_	29	case	_	_
22	the	the	DT	DT	_	29	det	_	_
23	Epstein-Barr	epstein-barr	JJ	JJ	_	29	amod	_	_
24	virus	virus	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	EBV	ebv	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	immediate-early	immediate-early	JJ	JJ	_	29	amod	_	_
29	protein	protein	NN	NN	_	20	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	BZLF1	bzlf1	NN	NN	_	29	appos	_	_
32	.	.	.	.	_	2	punct	_	_

1	Repertoire	repertoire	JJ	JJ	_	2	amod	_	_
2	selection	selection	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	monitored	monitor	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	determining	determine	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	11	det	_	_
8	TCR	tcr	NN	NN	_	11	compound	_	_
9	beta	beta	NN	NN	_	11	compound	_	_
10	chain	chain	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	6	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	RAKFKQLLQ-specific	rakfkqllq-specific	JJ	JJ	_	14	amod	_	_
14	CTL	ctl	NN	NN	_	11	nmod	_	_
15	established	establish	VBN	VBN	_	11	acl	_	_
16	from	from	IN	IN	_	18	case	_	_
17	primary	primary	JJ	JJ	_	18	amod	_	_
18	infected	infected	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	healthy	healthy	JJ	JJ	_	22	amod	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	carriers	carrier	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	PCR	pcr	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	spontaneous	spontaneous	JJ	JJ	_	8	amod	_	_
5	EBV-transformed	ebv-transformed	JJ	JJ	_	8	amod	_	_
6	lymphoblastoid	lymphoblastoid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	LCL	lcl	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	from	from	IN	IN	_	14	case	_	_
13	three	three	CD	CD	_	14	nummod	_	_
14	individuals	individual	NNS	NNS	_	8	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	infection	infection	NN	NN	_	14	nmod	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	two	two	CD	CD	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	infected	infect	VBN	VBN	_	18	ccomp	_	_
23	with	with	IN	IN	_	25	case	_	_
24	type	type	NN	NN	_	25	compound	_	_
25	A	a	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	one	one	CD	CD	_	22	conj	_	_
28	with	with	IN	IN	_	31	case	_	_
29	type	type	NN	NN	_	31	compound	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	EBV	ebv	NN	NN	_	27	dep	_	_
32	.	.	.	.	_	18	punct	_	_

1	Polyclonal	polyclonal	JJ	JJ	_	24	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	clonal	clonal	JJ	JJ	_	1	conj	_	_
4	CTL	ctl	NN	NN	_	1	dep	_	_
5	that	that	WDT	WDT	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	generated	generate	VBN	VBN	_	1	acl:relcl	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	stimulating	stimulate	VBG	VBG	_	7	advcl	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	dobj	_	_
14	with	with	IN	IN	_	23	case	_	_
15	an	a	DT	DT	_	23	det	_	_
16	HLA	hla	NN	NN	_	23	compound	_	_
17	B8+	b8+	JJ	JJ	_	23	amod	_	_
18	homozygous	homozygous	JJ	JJ	_	23	amod	_	_
19	LCL	lcl	NNS	NNS	_	23	compound	_	_
20	lysed	lysed	JJ	JJ	_	23	amod	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	blasts	blast	NNS	NNS	_	9	nmod	_	_
24	pulsed	pulsed	JJ	JJ	_	0	root	_	_
25	with	with	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	peptide	peptide	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	RAKFKQLLQ	rakfkqllq	NN	NN	_	27	appos	_	_
30	;	;	:	:	_	24	punct	_	_
31	lysis	lysis	NN	NN	_	39	nsubjpass	_	_
32	of	of	IN	IN	_	37	case	_	_
33	certain	certain	JJ	JJ	_	37	amod	_	_
34	HLA	hla	NN	NN	_	37	compound	_	_
35	B8+	b8+	JJ	JJ	_	37	amod	_	_
36	LCL	lcl	NNS	NNS	_	37	compound	_	_
37	targets	target	NNS	NNS	_	31	nmod	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	associated	associate	VBN	VBN	_	24	parataxis	_	_
40	with	with	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	abundance	abundance	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	45	case	_	_
44	BZLF1	bzlf1	NN	NN	_	45	compound	_	_
45	transcripts	transcript	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	24	punct	_	_

1	TCR	tcr	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	34	mark	_	_
6	while	while	IN	IN	_	8	mark	_	_
7	there	there	EX	EX	_	8	expl	_	_
8	was	be	VBD	VBD	_	34	advcl	_	_
9	loop	loop	NN	NN	_	11	compound	_	_
10	length	length	NN	NN	_	11	compound	_	_
11	restriction	restriction	NN	NN	_	8	nsubj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	putative	putative	JJ	JJ	_	17	amod	_	_
15	peptide	peptide	NN	NN	_	17	compound	_	_
16	contact	contact	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	8	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	all	all	DT	DT	_	22	det	_	_
20	responding	respond	VBG	VBG	_	22	amod	_	_
21	beta	beta	NN	NN	_	22	compound	_	_
22	chains	chain	NNS	NNS	_	17	nmod	_	_
23	,	,	,	,	_	34	punct	_	_
24	diverse	diverse	JJ	JJ	_	34	nsubjpass	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	unique	unique	JJ	JJ	_	32	amod	_	_
27	(	(	-LRB-	-LRB-	_	32	punct	_	_
28	non-recurrent	non-recurrent	JJ	JJ	_	32	amod	_	_
29	)	)	-RRB-	-RRB-	_	32	punct	_	_
30	TCR	tcr	NN	NN	_	32	compound	_	_
31	beta	beta	NN	NN	_	32	compound	_	_
32	clonotypes	clonotype	NNS	NNS	_	24	conj	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	selected	select	VBN	VBN	_	4	ccomp	_	_
35	in	in	IN	IN	_	36	case	_	_
36	individuals	individual	NNS	NNS	_	34	nmod	_	_
37	during	during	IN	IN	_	39	case	_	_
38	primary	primary	JJ	JJ	_	39	amod	_	_
39	infection	infection	NN	NN	_	36	nmod	_	_
40	and	and	CC	CC	_	34	cc	_	_
41	continued	continue	VBD	VBD	_	34	conj	_	_
42	to	to	TO	TO	_	43	mark	_	_
43	emerge	emerge	VB	VB	_	41	xcomp	_	_
44	after	after	IN	IN	_	47	case	_	_
45	long-term	long-term	JJ	JJ	_	47	amod	_	_
46	virus	virus	NN	NN	_	47	compound	_	_
47	exposure	exposure	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	4	punct	_	_

1	TCR-contact	tcr-contact	JJ	JJ	_	3	amod	_	_
2	site	site	NN	NN	_	3	compound	_	_
3	heterogeneity	heterogeneity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	excluded	exclude	VBN	VBN	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	selective	selective	JJ	JJ	_	9	amod	_	_
9	force	force	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	diversity	diversity	NN	NN	_	12	compound	_	_
12	generation	generation	NN	NN	_	9	nmod	_	_
13	since	since	IN	IN	_	18	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	epitope-encoded	epitope-encoded	JJ	JJ	_	16	amod	_	_
16	sequences	sequence	NNS	NNS	_	18	nsubjpass	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	5	advcl	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	identical	identical	JJ	JJ	_	18	xcomp	_	_
22	within	within	IN	IN	_	25	case	_	_
23	endogenous	endogenous	JJ	JJ	_	25	amod	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	isolates	isolate	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	22	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	TCR	tcr	NN	NN	_	7	compound	_	_
7	repertoire	repertoire	NN	NN	_	8	compound	_	_
8	selection	selection	NN	NN	_	4	nmod	_	_
9	for	for	IN	IN	_	13	case	_	_
10	an	a	DT	DT	_	13	det	_	_
11	EBV	ebv	NN	NN	_	13	compound	_	_
12	lytic	lytic	JJ	JJ	_	13	amod	_	_
13	antigen	antigen	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	22	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	BZLF1-reactive	bzlf1-reactive	JJ	JJ	_	17	amod	_	_
17	component	component	NN	NN	_	22	nsubjpass	_	_
18	of	of	IN	IN	_	20	case	_	_
19	diverse	diverse	JJ	JJ	_	20	amod	_	_
20	clonotypes	clonotype	NNS	NNS	_	17	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	identified	identify	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	26	case	_	_
24	primary	primary	JJ	JJ	_	26	amod	_	_
25	type	type	NN	NN	_	26	compound	_	_
26	A	a	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	type	type	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	conj	_	_
30	EBV	ebv	NN	NN	_	31	compound	_	_
31	infection	infection	NN	NN	_	26	dep	_	_
32	which	which	WDT	WDT	_	34	nsubj	_	_
33	was	be	VBD	VBD	_	34	cop	_	_
34	sustained	sustained	JJ	JJ	_	26	acl:relcl	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	EBV-specific	ebv-specific	JJ	JJ	_	39	amod	_	_
38	memory	memory	NN	NN	_	39	compound	_	_
39	response	response	NN	NN	_	34	nmod	_	_
40	throughout	throughout	IN	IN	_	42	case	_	_
41	life-long	life-long	JJ	JJ	_	42	amod	_	_
42	infection	infection	NN	NN	_	34	nmod	_	_
43	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	diversity	diversity	NN	NN	_	3	compound	_	_
3	selection	selection	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	likely	likely	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	play	play	VB	VB	_	5	xcomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	critical	critical	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	maintaining	maintain	VBG	VBG	_	7	advcl	_	_
13	a	a	DT	DT	_	16	det	_	_
14	balanced	balanced	JJ	JJ	_	16	amod	_	_
15	viral	viral	JJ	JJ	_	14	dep	_	_
16	load	load	NN	NN	_	12	dobj	_	_
17	throughout	throughout	IN	IN	_	19	case	_	_
18	EBV	ebv	NN	NN	_	19	compound	_	_
19	persistence	persistence	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	17	nsubj	_	_
3	c-fos	c-fos	NN	NN	_	2	dep	_	_
4	,	,	,	,	_	3	punct	_	_
5	c-jun	c-jun	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	NF	nf	NN	NN	_	10	compound	_	_
9	kappa	kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	3	conj	_	_
11	mRNA	mrna	NN	NN	_	3	dep	_	_
12	is	be	VBZ	VBZ	_	17	cop	_	_
13	in	in	IN	IN	_	17	case	_	_
14	nucleated	nucleated	JJ	JJ	_	17	amod	_	_
15	fetal	fetal	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	up-regulation	up-regulation	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	c-fos	c-fos	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	c-jun	c-jun	NN	NN	_	21	conj	_	_
24	with	with	IN	IN	_	26	case	_	_
25	anti-CD3	anti-cd3	JJ	JJ	_	26	compound	_	_
26	stimulation	stimulation	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Fetal	fetal	JJ	JJ	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	neonatal	neonatal	JJ	JJ	_	1	conj	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	dep	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	relatively	relatively	RB	RB	_	7	advmod	_	_
7	resistant	resistant	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	conj	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	stimulated	stimulate	VBN	VBN	_	7	advcl	_	_
15	either	either	CC	CC	_	20	dep	_	_
16	via	via	IN	IN	_	20	case	_	_
17	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
18	T-cell	t-cell	NN	NN	_	20	compound	_	_
19	antigen	antigen	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	14	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	lectins	lectin	NNS	NNS	_	20	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	molecular	molecular	JJ	JJ	_	5	amod	_	_
3	mechanism	mechanism	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	s	s	NNS	NNS	_	15	nsubjpass	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	responsible	responsible	JJ	JJ	_	5	amod	_	_
8	for	for	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	phenomenon	phenomenon	NN	NN	_	7	nmod	_	_
11	have	have	VBP	VBP	_	15	aux	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	been	be	VBN	VBN	_	15	auxpass	_	_
14	clearly	clearly	RB	RB	_	15	advmod	_	_
15	elucidated	elucidate	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	such	such	JJ	JJ	_	6	amod	_	_
6	defects	defect	NNS	NNS	_	13	nsubj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	fetal/neonatal	fetal/neonatal	JJ	JJ	_	10	amod	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	due	due	JJ	JJ	_	3	ccomp	_	_
14	to	to	TO	TO	_	15	case	_	_
15	lack	lack	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	expression	expression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	17	nmod	_	_
23	required	require	VBN	VBN	_	22	acl	_	_
24	for	for	IN	IN	_	26	case	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	reverse	reverse	JJ	JJ	_	6	amod	_	_
4	transcriptase-polymerase	transcriptase-polymerase	JJ	JJ	_	6	amod	_	_
5	chain	chain	NN	NN	_	6	compound	_	_
6	reaction	reaction	NN	NN	_	2	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	examine	examine	VB	VB	_	2	advcl	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	fetal	fetal	JJ	JJ	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	term	term	JJ	JJ	_	13	amod	_	_
13	neonatal	neonatal	JJ	JJ	_	10	conj	_	_
14	cord	cord	NN	NN	_	15	compound	_	_
15	bloods	blood	NNS	NNS	_	10	dep	_	_
16	for	for	IN	IN	_	18	case	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	8	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	three	three	CD	CD	_	22	nummod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	18	nmod	_	_
23	implicated	implicate	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	:	:	:	:	_	2	punct	_	_
28	c-jun	c-jun	NN	NN	_	2	dep	_	_
29	,	,	,	,	_	28	punct	_	_
30	c-fos	c-fos	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	NF	nf	NN	NN	_	35	compound	_	_
34	kappa	kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	28	conj	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	p50	p50	NN	NN	_	38	compound	_	_
38	subunit	subunit	NN	NN	_	35	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	mRNAs	mrna	NNS	NNS	_	13	nsubjpass	_	_
5	for	for	IN	IN	_	7	case	_	_
6	all	all	DT	DT	_	7	det	_	_
7	three	three	CD	CD	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	2	ccomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	fetal	fetal	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	27th	27th	JJ	JJ	_	21	amod	_	_
21	week	week	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	gestation	gestation	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	in	in	IN	IN	_	28	case	_	_
26	term	term	NN	NN	_	28	compound	_	_
27	cord	cord	NN	NN	_	28	compound	_	_
28	bloods	blood	NNS	NNS	_	17	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	term	term	NN	NN	_	8	compound	_	_
4	infant	infant	NN	NN	_	8	compound	_	_
5	cord	cord	NN	NN	_	8	compound	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	anti-CD3	anti-cd3	JJ	JJ	_	12	amod	_	_
11	monoclonal	monoclonal	JJ	JJ	_	12	amod	_	_
12	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	up-regulation	up-regulation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	c-jun	c-jun	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	c-fos	c-fos	NN	NN	_	18	conj	_	_
21	mRNAs	mrna	NNS	NNS	_	18	dep	_	_
22	within	within	IN	IN	_	24	case	_	_
23	15	15	CD	CD	_	24	nummod	_	_
24	min	min	NN	NN	_	15	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	secretion	secretion	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	11	case	_	_
7	anti-CD3-stimulated	anti-cd3-stimulated	JJ	JJ	_	11	amod	_	_
8	cord	cord	NN	NN	_	11	compound	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	still	still	RB	RB	_	14	advmod	_	_
14	blunted	blunt	VBN	VBN	_	0	root	_	_
15	compared	compare	VBN	VBN	_	18	case	_	_
16	with	with	IN	IN	_	18	case	_	_
17	control	control	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	advcl	_	_
19	from	from	IN	IN	_	20	case	_	_
20	adults	adult	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	fetal	fetal	JJ	JJ	_	7	amod	_	_
5	nucleated	nucleated	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	9	nsubj	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	express	express	VBP	VBP	_	2	ccomp	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	9	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	able	able	JJ	JJ	_	9	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	increase	increase	VB	VB	_	17	xcomp	_	_
20	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
21	accumulation	accumulation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	mRNAs	mrna	NNS	NNS	_	21	nmod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	response	response	NN	NN	_	19	nmod	_	_
30	to	to	TO	TO	_	32	case	_	_
31	anti-CD3	anti-cd3	JJ	JJ	_	32	compound	_	_
32	stimulation	stimulation	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	qualitative	qualitative	JJ	JJ	_	4	amod	_	_
4	differences	difference	NNS	NNS	_	15	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	capacity	capacity	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	regulate	regulate	VB	VB	_	7	acl	_	_
10	these	these	DT	DT	_	11	det	_	_
11	factors	factor	NNS	NNS	_	9	dobj	_	_
12	could	could	MD	MD	_	15	aux	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	fetal	fetal	JJ	JJ	_	19	amod	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Quantitative	quantitative	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	16	nsubj	_	_
3	comparing	compare	VBG	VBG	_	2	acl	_	_
4	binding	binding	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	4	nmod	_	_
13	are	be	VBP	VBP	_	16	cop	_	_
14	currently	currently	RB	RB	_	16	advmod	_	_
15	under	under	IN	IN	_	16	case	_	_
16	investigation	investigation	NN	NN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Replication	replication	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	5	compound	_	_
5	virus-1	virus-1	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	primary	primary	JJ	JJ	_	10	amod	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	autocrine	autocrine	JJ	JJ	_	16	amod	_	_
16	secretion	secretion	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	tumor	tumor	NN	NN	_	20	compound	_	_
19	necrosis	necrosis	NN	NN	_	20	compound	_	_
20	factor	factor	NN	NN	_	16	nmod	_	_
21	through	through	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	control	control	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
26	factor-kappa	factor-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Tumor	tumor	NN	NN	_	7	compound	_	_
2	necrosis	necrosis	NN	NN	_	7	compound	_	_
3	factor	factor	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	TNF	tnf	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	-alpha	-alpha	NN	NN	_	8	nsubj	_	_
8	controls	control	VBZ	VBZ	_	0	root	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	major	major	JJ	JJ	_	15	amod	_	_
15	inducer	inducer	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	24	case	_	_
17	human	human	JJ	JJ	_	24	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	24	compound	_	_
19	virus	virus	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	HIV	hiv	NN	NN	_	24	compound	_	_
22	)	)	-RRB-	-RRB-	_	24	punct	_	_
23	-1	-1	CD	CD	_	24	nummod	_	_
24	replication	replication	NN	NN	_	15	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	chronically	chronically	RB	RB	_	28	advmod	_	_
27	infected	infected	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	investigated	investigate	VBN	VBN	_	0	root	_	_
6	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	primary	primary	JJ	JJ	_	10	amod	_	_
10	cultures	culture	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	HIV-infected	hiv-infected	JJ	JJ	_	15	amod	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	5	advcl	_	_
18	neutralizing	neutralize	VBG	VBG	_	20	amod	_	_
19	anti-TNF-alpha	anti-tnf-alpha	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	17	dobj	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Primary	primary	JJ	JJ	_	4	amod	_	_
2	resting	rest	VBG	VBG	_	1	dep	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	5	nsubj	_	_
5	produced	produce	VBD	VBD	_	0	root	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	supported	support	VBD	VBD	_	5	conj	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	8	dobj	_	_
11	after	after	IN	IN	_	14	case	_	_
12	T-cell	t-cell	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	5	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Addition	addition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	neutralizing	neutralize	VBG	VBG	_	5	amod	_	_
4	anti-TNF-alpha	anti-tnf-alpha	JJ	JJ	_	5	amod	_	_
5	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
6	drastically	drastically	RB	RB	_	7	advmod	_	_
7	reduced	reduce	VBD	VBD	_	0	root	_	_
8	p24	p24	NN	NN	_	9	compound	_	_
9	antigen	antigen	NN	NN	_	10	compound	_	_
10	release	release	NN	NN	_	7	dobj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	prevented	prevent	VBD	VBD	_	7	conj	_	_
13	CD4+	cd4+	JJ	JJ	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	depletion	depletion	NN	NN	_	12	dobj	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	infection	infection	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Anti-TNF-alpha	anti-tnf-alpha	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	prevented	prevent	VBD	VBD	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
5	factor-kappa	factor-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	activation	activation	NN	NN	_	3	dobj	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	a	a	DT	DT	_	16	det	_	_
15	good	good	JJ	JJ	_	16	amod	_	_
16	correlation	correlation	NN	NN	_	26	nsubjpass	_	_
17	between	between	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	inhibition	inhibition	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	inhibition	inhibition	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	HIV	hiv	NN	NN	_	24	compound	_	_
24	replication	replication	NN	NN	_	21	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	observed	observe	VBN	VBN	_	3	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	supplementing	supplement	VBG	VBG	_	11	csubj	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cultures	culture	NNS	NNS	_	3	dobj	_	_
6	with	with	IN	IN	_	8	case	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	doses	dose	NNS	NNS	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IL-2	il-2	NN	NN	_	8	nmod	_	_
11	reverted	revert	VBD	VBD	_	0	root	_	_
12	anti-TNF-alpha	anti-tnf-alpha	JJ	JJ	_	13	amod	_	_
13	inhibition	inhibition	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	proliferation	proliferation	NN	NN	_	13	nmod	_	_
17	but	but	CC	CC	_	11	cc	_	_
18	did	do	VBD	VBD	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	affect	affect	VB	VB	_	11	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	inhibition	inhibition	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	HIV	hiv	NN	NN	_	27	compound	_	_
25	p24	p24	NN	NN	_	26	compound	_	_
26	antigen	antigen	NN	NN	_	27	compound	_	_
27	release	release	NN	NN	_	22	nmod	_	_
28	or	or	CC	CC	_	22	cc	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	22	conj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	same	same	JJ	JJ	_	35	amod	_	_
35	cultures	culture	NNS	NNS	_	22	nmod	_	_
36	.	.	.	.	_	11	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	anti-TNF-alpha	anti-tnf-alpha	NN	NN	_	4	nsubj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
6	long	long	JJ	JJ	_	8	amod	_	_
7	terminal	terminal	JJ	JJ	_	8	amod	_	_
8	repeat	repeat	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	LTR	ltr	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	-driven	-driven	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	4	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	primary	primary	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	response	response	NN	NN	_	13	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	activation	activation	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	4	punct	_	_
27	either	either	CC	CC	_	30	dep	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	presence	presence	NN	NN	_	4	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	the	the	DT	DT	_	33	det	_	_
33	absence	absence	NN	NN	_	30	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	HIV-1	hiv-1	NN	NN	_	36	compound	_	_
36	Tat	tat	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	autocrine	autocrine	JJ	JJ	_	10	amod	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	controlling	control	VBG	VBG	_	3	advcl	_	_
13	HIV	hiv	NN	NN	_	14	compound	_	_
14	replication	replication	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	primary	primary	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	because	because	IN	IN	_	22	case	_	_
20	of	of	IN	IN	_	22	case	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	ability	ability	NN	NN	_	12	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	maintain	maintain	VB	VB	_	22	acl	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	27	nsubj	_	_
27	elevated	elevated	JJ	JJ	_	24	xcomp	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	thiol	thiol	NN	NN	_	3	compound	_	_
3	antioxidant	antioxidant	NN	NN	_	4	nsubj	_	_
4	regulates	regulate	VBZ	VBZ	_	0	root	_	_
5	IgE	ige	NN	NN	_	6	compound	_	_
6	isotype	isotype	NN	NN	_	7	compound	_	_
7	switching	switching	NN	NN	_	4	dobj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	inhibiting	inhibit	VBG	VBG	_	4	advcl	_	_
10	activation	activation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor-kappaB	factor-kappab	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	binding	bind	VBG	VBG	_	3	amod	_	_
3	site	site	NN	NN	_	11	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factor-kappaB	factor-kappab	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	present	present	JJ	JJ	_	0	root	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	region	region	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	germline	germline	NN	NN	_	20	compound	_	_
19	Cepsilon	cepsilon	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	11	punct	_	_
22	but	but	CC	CC	_	11	cc	_	_
23	there	there	EX	EX	_	24	expl	_	_
24	is	be	VBZ	VBZ	_	11	conj	_	_
25	little	little	JJ	JJ	_	26	amod	_	_
26	information	information	NN	NN	_	24	nsubj	_	_
27	on	on	IN	IN	_	32	mark	_	_
28	whether	whether	IN	IN	_	32	mark	_	_
29	this	this	DT	DT	_	30	det	_	_
30	factor	factor	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	involved	involve	VBN	VBN	_	26	acl	_	_
33	in	in	IN	IN	_	34	mark	_	_
34	regulating	regulate	VBG	VBG	_	32	advcl	_	_
35	IgE	ige	NN	NN	_	36	compound	_	_
36	synthesis	synthesis	NN	NN	_	34	dobj	_	_
37	by	by	IN	IN	_	40	case	_	_
38	human	human	JJ	JJ	_	40	amod	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	11	punct	_	_

1	Accordingly	accordingly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	germline	germline	NN	NN	_	12	compound	_	_
11	Cepsilon	cepsilon	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	6	nmod	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	using	use	VBG	VBG	_	4	advcl	_	_
15	two	two	CD	CD	_	22	nummod	_	_
16	human	human	JJ	JJ	_	22	amod	_	_
17	Burkitt	burkitt	NN	NN	_	22	nmod:poss	_	_
18	's	's	POS	POS	_	22	case	_	_
19	lymphoma	lymphoma	NN	NN	_	22	compound	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	14	dobj	_	_
23	,	,	,	,	_	22	punct	_	_
24	DND39	dnd39	NN	NN	_	22	appos	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	DG75	dg75	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	both	both	DT	DT	_	4	dep	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	16	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	n-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NAC	nac	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	a	a	DT	DT	_	14	det	_	_
12	potent	potent	JJ	JJ	_	14	amod	_	_
13	thiol	thiol	NN	NN	_	14	compound	_	_
14	antioxidant	antioxidant	NN	NN	_	6	appos	_	_
15	,	,	,	,	_	6	punct	_	_
16	inhibited	inhibit	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	triggering	triggering	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	22	nmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	IL-4	il-4	NN	NN	_	18	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	by	by	IN	IN	_	31	case	_	_
29	anti-CD40	anti-cd40	JJ	JJ	_	31	amod	_	_
30	monoclonal	monoclonal	JJ	JJ	_	31	amod	_	_
31	antibody	antibody	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	16	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	IL-4	il-4	NN	NN	_	3	nsubj	_	_
3	activated	activate	VBD	VBD	_	33	advcl	_	_
4	signal	signal	NN	NN	_	5	compound	_	_
5	transducers	transducer	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activators	activator	NNS	NNS	_	11	compound	_	_
8	of	of	IN	IN	_	11	amod	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	STAT	stat	NNS	NNS	_	5	conj	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	6	6	CD	CD	_	11	nummod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	addition	addition	NN	NN	_	3	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	33	punct	_	_
19	NAC	nac	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	33	nsubj	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	23	det	_	_
23	transfection	transfection	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	decoy	decoy	NN	NN	_	26	compound	_	_
26	oligodeoxynucleotides	oligodeoxynucleotide	NNS	NNS	_	23	nmod	_	_
27	for	for	IN	IN	_	28	case	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	26	nmod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	STAT6	stat6	NN	NN	_	28	conj	_	_
31	only	only	RB	RB	_	32	advmod	_	_
32	partly	partly	RB	RB	_	33	advmod	_	_
33	blocked	block	VBD	VBD	_	0	root	_	_
34	IL-4-induced	il-4-induced	JJ	JJ	_	37	amod	_	_
35	germline	germline	NN	NN	_	37	compound	_	_
36	Cepsilon	cepsilon	NN	NN	_	37	compound	_	_
37	transcription	transcription	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	33	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	these	these	DT	DT	_	6	det	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	decoy	decoy	NN	NN	_	6	compound	_	_
6	oligodeoxynucleotides	oligodeoxynucleotide	NNS	NNS	_	10	nsubj	_	_
7	together	together	RB	RB	_	10	advmod	_	_
8	almost	almost	RB	RB	_	9	advmod	_	_
9	completely	completely	RB	RB	_	10	advmod	_	_
10	abrogated	abrogate	VBD	VBD	_	0	root	_	_
11	IL-4-induced	il-4-induced	JJ	JJ	_	14	amod	_	_
12	germline	germline	NN	NN	_	14	compound	_	_
13	Cepsilon	cepsilon	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	Of	of	IN	IN	_	2	case	_	_
2	note	note	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	CD40-mediated	cd40-mediated	JJ	JJ	_	5	amod	_	_
5	enhancement	enhancement	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	IL-4-driven	il-4-driven	JJ	JJ	_	10	amod	_	_
8	germline	germline	NN	NN	_	10	compound	_	_
9	Cepsilon	cepsilon	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	5	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	decreased	decrease	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	NAC	nac	NN	NN	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	by	by	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	decoy	decoy	NN	NN	_	20	compound	_	_
20	oligodeoxynucleotide	oligodeoxynucleotide	NN	NN	_	15	conj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NAC	nac	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	examined	examine	VBN	VBN	_	0	root	_	_
8	on	on	IN	IN	_	11	case	_	_
9	deletional	deletional	JJ	JJ	_	11	amod	_	_
10	switch	switch	NN	NN	_	11	compound	_	_
11	recombination	recombination	NN	NN	_	7	nmod	_	_
12	underlying	underlie	VBG	VBG	_	11	acl	_	_
13	the	the	DT	DT	_	15	det	_	_
14	isotype	isotype	NN	NN	_	15	compound	_	_
15	switch	switch	NN	NN	_	12	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	IgE	ige	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	NAC	nac	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	generation	generation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	Smu/Sepsilon	smu/sepsilon	NN	NN	_	8	compound	_	_
7	switch	switch	NN	NN	_	8	compound	_	_
8	fragments	fragment	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	costimulated	costimulate	VBN	VBN	_	13	acl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	IL-4	il-4	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	anti-CD40	anti-cd40	JJ	JJ	_	20	amod	_	_
19	monoclonal	monoclonal	JJ	JJ	_	20	amod	_	_
20	antibody	antibody	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	abolished	abolish	VBD	VBD	_	0	root	_	_
4	IL-4-induced	il-4-induced	JJ	JJ	_	5	amod	_	_
5	upregulation	upregulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CD40	cd40	NN	NN	_	5	nmod	_	_
8	but	but	CC	CC	_	3	cc	_	_
9	promoted	promote	VBD	VBD	_	3	conj	_	_
10	upregulation	upregulation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD23	cd23	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	coordination	coordination	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	STAT6	stat6	NN	NN	_	7	conj	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	3	ccomp	_	_
13	for	for	IN	IN	_	14	case	_	_
14	induction	induction	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	germline	germline	NN	NN	_	18	compound	_	_
17	Cepsilon	cepsilon	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	14	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	IL-4	il-4	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	that	that	IN	IN	_	29	mark	_	_
24	CD40-mediated	cd40-mediated	JJ	JJ	_	26	amod	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	29	nsubj	_	_
27	may	may	MD	MD	_	29	aux	_	_
28	be	be	VB	VB	_	29	cop	_	_
29	important	important	JJ	JJ	_	12	conj	_	_
30	in	in	IN	IN	_	31	mark	_	_
31	regulating	regulate	VBG	VBG	_	29	advcl	_	_
32	both	both	CC	CC	_	33	cc:preconj	_	_
33	enhancement	enhancement	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	germline	germline	NN	NN	_	37	compound	_	_
36	Cepsilon	cepsilon	NN	NN	_	37	compound	_	_
37	transcription	transcription	NN	NN	_	33	nmod	_	_
38	and	and	CC	CC	_	33	cc	_	_
39	class	class	NN	NN	_	40	compound	_	_
40	switching	switching	NN	NN	_	33	conj	_	_
41	to	to	TO	TO	_	42	case	_	_
42	IgE	ige	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	molecular	molecular	JJ	JJ	_	1	conj	_	_
4	mechanisms	mechanism	NNS	NNS	_	1	dep	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IL-5	il-5	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	atopic	atopic	JJ	JJ	_	10	amod	_	_
10	diseases	disease	NNS	NNS	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	a	a	DT	DT	_	13	det	_	_
13	study	study	NN	NN	_	1	dep	_	_
14	with	with	IN	IN	_	19	case	_	_
15	allergen-specific	allergen-specific	JJ	JJ	_	19	amod	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	helper	helper	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Cytokines	cytokine	NNS	NNS	_	11	nsubjpass	_	_
4	produced	produce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	helper	helper	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	are	be	VBP	VBP	_	11	auxpass	_	_
10	intimately	intimately	RB	RB	_	11	advmod	_	_
11	involved	involve	VBN	VBN	_	1	dep	_	_
12	in	in	IN	IN	_	15	case	_	_
13	chronic	chronic	JJ	JJ	_	15	amod	_	_
14	allergic	allergic	JJ	JJ	_	15	amod	_	_
15	diseases	disease	NNS	NNS	_	11	nmod	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	eosinophilic	eosinophilic	JJ	JJ	_	19	amod	_	_
19	inflammation	inflammation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	1	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	production	production	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-5	il-5	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	13	dep	_	_
11	potent	potent	JJ	JJ	_	13	amod	_	_
12	growth	growth	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	8	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	chemotactic	chemotactic	JJ	JJ	_	16	amod	_	_
16	factor	factor	NN	NN	_	13	conj	_	_
17	for	for	IN	IN	_	18	case	_	_
18	eosinophils	eosinophil	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	by	by	IN	IN	_	23	case	_	_
21	CD4+	cd4+	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	patients	patient	NNS	NNS	_	4	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	asthma	asthma	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Allergen-specific	allergen-specific	JJ	JJ	_	6	amod	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	clones	clone	NNS	NNS	_	12	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	hybridomas	hybridoma	NNS	NNS	_	6	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	established	establish	VBN	VBN	_	1	dep	_	_
13	from	from	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	asthma	asthma	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	responses	response	NNS	NNS	_	30	nsubjpass	_	_
26	to	to	TO	TO	_	28	case	_	_
27	various	various	JJ	JJ	_	28	amod	_	_
28	stimuli	stimulus	NNS	NNS	_	25	nmod	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	determined	determine	VBN	VBN	_	12	conj	_	_
31	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	After	after	IN	IN	_	5	case	_	_
4	nonspecific	nonspecific	JJ	JJ	_	5	amod	_	_
5	stimulation	stimulation	NN	NN	_	23	nmod	_	_
6	,	,	,	,	_	23	punct	_	_
7	IL-5	il-5	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	23	nsubjpass	_	_
9	by	by	IN	IN	_	12	case	_	_
10	CD4+	cd4+	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	atopic	atopic	JJ	JJ	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	nonatopic	nonatopic	JJ	JJ	_	15	conj	_	_
18	subjects	subject	NNS	NNS	_	15	dep	_	_
19	with	with	IN	IN	_	20	case	_	_
20	asthma	asthma	NN	NN	_	15	nmod	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	enhanced	enhance	VBN	VBN	_	1	dep	_	_
24	compared	compare	VBN	VBN	_	26	case	_	_
25	with	with	IN	IN	_	26	case	_	_
26	that	that	DT	DT	_	23	advcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	cells	cell	NNS	NNS	_	26	nmod	_	_
29	from	from	IN	IN	_	31	case	_	_
30	healthy	healthy	JJ	JJ	_	31	amod	_	_
31	controls	control	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	10	nsubj	_	_
5	from	from	IN	IN	_	8	case	_	_
6	atopic	atopic	JJ	JJ	_	8	amod	_	_
7	asthma	asthma	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	4	nmod	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	proliferated	proliferate	VBD	VBD	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	produced	produce	VBD	VBD	_	10	conj	_	_
13	IL-5	il-5	NN	NN	_	12	dobj	_	_
14	after	after	IN	IN	_	15	case	_	_
15	incubation	incubation	NN	NN	_	10	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	mite	mite	JJ	JJ	_	18	amod	_	_
18	allergen	allergen	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
21	that	that	IN	IN	_	27	mark	_	_
22	mite-specific	mite-specific	JJ	JJ	_	25	amod	_	_
23	helper	helper	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	27	nsubjpass	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	involved	involve	VBN	VBN	_	20	ccomp	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	eosinophilic	eosinophilic	JJ	JJ	_	31	amod	_	_
31	inflammation	inflammation	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	atopic	atopic	JJ	JJ	_	34	amod	_	_
34	asthma	asthma	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	IL-5	il-5	NN	NN	_	7	compound	_	_
4	promoter/enhancer	promoter/enhancer	NN	NN	_	7	compound	_	_
5	luciferase	luciferase	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	construct	construct	NN	NN	_	16	nsubjpass	_	_
8	transfected	transfect	VBN	VBN	_	7	acl	_	_
9	into	into	IN	IN	_	13	case	_	_
10	IL-5-producing	il-5-producing	JJ	JJ	_	13	amod	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	clones	clone	NNS	NNS	_	8	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	clearly	clearly	RB	RB	_	16	advmod	_	_
16	transcribed	transcribe	VBN	VBN	_	0	root	_	_
17	after	after	IN	IN	_	18	case	_	_
18	stimulation	stimulation	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	indicating	indicate	VBG	VBG	_	16	advcl	_	_
21	that	that	IN	IN	_	35	mark	_	_
22	the	the	DT	DT	_	25	det	_	_
23	515	515	CD	CD	_	25	nummod	_	_
24	base	base	NN	NN	_	25	compound	_	_
25	pair	pair	NN	NN	_	35	nsubj	_	_
26	IL-5	il-5	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	segment	segment	NN	NN	_	25	dep	_	_
29	upstream	upstream	JJ	JJ	_	25	advmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	coding	code	VBG	VBG	_	33	amod	_	_
33	region	region	NN	NN	_	29	nmod	_	_
34	was	be	VBD	VBD	_	35	cop	_	_
35	sufficient	sufficient	JJ	JJ	_	20	ccomp	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	respond	respond	VB	VB	_	35	xcomp	_	_
38	to	to	TO	TO	_	40	case	_	_
39	activating	activate	VBG	VBG	_	40	amod	_	_
40	signals	signal	NNS	NNS	_	37	nmod	_	_
41	in	in	IN	IN	_	45	case	_	_
42	human	human	JJ	JJ	_	45	amod	_	_
43	helper	helper	NN	NN	_	45	compound	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	40	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	same	same	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	segment	segment	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	transcribed	transcribe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	IL-5-nonproducing	il-5-nonproducing	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	clones	clone	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	suggesting	suggest	VBG	VBG	_	7	advcl	_	_
15	that	that	IN	IN	_	22	mark	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	T	t	NN	NN	_	20	compound	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	IL-5	il-5	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	regulated	regulate	VBN	VBN	_	14	ccomp	_	_
23	at	at	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	level	level	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	Experiments	experiment	NNS	NNS	_	6	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	hybridomas	hybridoma	NNS	NNS	_	1	nmod	_	_
6	confirmed	confirm	VBD	VBD	_	0	root	_	_
7	these	these	DT	DT	_	8	det	_	_
8	findings	finding	NNS	NNS	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	suggested	suggest	VBD	VBD	_	6	conj	_	_
11	that	that	IN	IN	_	18	mark	_	_
12	a	a	DT	DT	_	15	det	_	_
13	unique	unique	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	18	nsubj	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	essential	essential	JJ	JJ	_	10	ccomp	_	_
19	for	for	IN	IN	_	23	case	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	IL-5	il-5	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Enhanced	enhance	VBN	VBN	_	5	amod	_	_
4	IL-5	il-5	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	10	nsubj	_	_
6	by	by	IN	IN	_	9	case	_	_
7	helper	helper	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	seems	seem	VBZ	VBZ	_	1	dep	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	cause	cause	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	eosinophilic	eosinophilic	JJ	JJ	_	15	amod	_	_
15	inflammation	inflammation	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	atopic	atopic	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	nonatopic	nonatopic	JJ	JJ	_	18	conj	_	_
21	asthma	asthma	NN	NN	_	18	dep	_	_
22	.	.	.	.	_	1	punct	_	_

1	Elucidation	elucidation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IL-5-specific	il-5-specific	JJ	JJ	_	5	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	1	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	facilitate	facilitate	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	development	development	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	novel	novel	JJ	JJ	_	12	amod	_	_
12	treatments	treatment	NNS	NNS	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	allergic	allergic	JJ	JJ	_	15	amod	_	_
15	diseases	disease	NNS	NNS	_	12	nmod	_	_
16	associated	associate	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	eosinophilic	eosinophilic	JJ	JJ	_	19	amod	_	_
19	inflammation	inflammation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	10	case	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	I	i	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	10	conj	_	_
16	stability	stability	NN	NN	_	10	dep	_	_
17	.	.	.	.	_	1	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	7	nsubjpass	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	2	dep	_	_
5	must	must	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	released	release	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	11	case	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	molecules	molecule	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	I	i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	Bs	b	NNS	NNS	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	20	mark	_	_
18	order	order	NN	NN	_	17	mwe	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	move	move	VB	VB	_	7	advcl	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	nucleus	nucleus	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	activate	activate	VB	VB	_	20	conj	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	target	target	NN	NN	_	29	compound	_	_
29	genes	gene	NNS	NNS	_	26	dobj	_	_
30	.	.	.	.	_	7	punct	_	_

1	Little	little	JJ	JJ	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	about	about	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanisms	mechanism	NNS	NNS	_	3	nmod	_	_
7	regulating	regulate	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	maintenance	maintenance	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	constitutive	constitutive	JJ	JJ	_	14	amod	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	some	some	DT	DT	_	17	det	_	_
17	cell-types	cell-type	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	of	of	IN	IN	_	24	case	_	_
20	sustained	sustained	JJ	JJ	_	24	amod	_	_
21	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	14	conj	_	_
25	after	after	IN	IN	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	turnover	turnover	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	implicated	implicate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	constitutive	constitutive	JJ	JJ	_	13	amod	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	mature	mature	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	compared	compare	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	turnover	turnover	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	I	i	NN	NN	_	15	compound	_	_
13	kappa	kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	10	conj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	mature	mature	JJ	JJ	_	19	amod	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	5	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	HeLa	hela	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	3	nsubj	_	_
3	display	display	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	high	high	JJ	JJ	_	6	amod	_	_
6	turnover	turnover	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	although	although	IN	IN	_	18	mark	_	_
11	I	i	NN	NN	_	14	compound	_	_
12	kappa	kappa	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	beta	beta	NN	NN	_	18	nsubj	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	considerably	considerably	RB	RB	_	17	advmod	_	_
17	more	more	RBR	RBR	_	18	advmod	_	_
18	stable	stable	JJ	JJ	_	3	advcl	_	_
19	than	than	IN	IN	_	23	case	_	_
20	I	i	NN	NN	_	23	compound	_	_
21	kappa	kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	half-life	half-life	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	det	_	_
5	inhibitors	inhibitor	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	increased	increase	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	HeLa	hela	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	all	all	DT	DT	_	10	det	_	_
5	other	other	JJ	JJ	_	10	amod	_	_
6	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
7	B/I	b/i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	molecules	molecule	NNS	NNS	_	14	nsubj	_	_
11	tested	test	VBN	VBN	_	10	acl	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	relatively	relatively	RB	RB	_	14	advmod	_	_
14	stable	stable	JJ	JJ	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	both	both	DT	DT	_	17	det	_	_
17	cell-types	cell-type	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	elevated	elevated	JJ	JJ	_	3	amod	_	_
3	turnover	turnover	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	endogenous	endogenous	JJ	JJ	_	9	amod	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Namalwa	namalwa	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	inhibited	inhibit	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	proteasome	proteasome	NN	NN	_	18	compound	_	_
18	inhibitor	inhibitor	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	thus	thus	RB	RB	_	21	advmod	_	_
21	seems	seem	VBZ	VBZ	_	14	conj	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	driven	drive	VBN	VBN	_	21	xcomp	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	same	same	JJ	JJ	_	29	amod	_	_
28	degradation	degradation	NN	NN	_	29	compound	_	_
29	machinery	machinery	NN	NN	_	24	nmod	_	_
30	as	as	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	slower	slower	JJR	JJR	_	33	amod	_	_
33	turnover	turnover	NN	NN	_	29	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	non-B	non-b	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	processes	process	NNS	NNS	_	4	dobj	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	persistent	persistent	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	2	compound	_	_
2	signaling	signaling	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	rapid	rapid	JJ	JJ	_	7	amod	_	_
7	depletion	depletion	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	cellular	cellular	JJ	JJ	_	14	amod	_	_
10	I	i	NN	NN	_	13	compound	_	_
11	kappa	kappa	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	beta	beta	NN	NN	_	14	compound	_	_
14	pools	pool	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	I	i	NN	NN	_	4	compound	_	_
2	kappa	kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	efficiently	efficiently	RB	RB	_	7	advmod	_	_
7	resynthesized	resynthesize	VBN	VBN	_	0	root	_	_
8	whereas	whereas	IN	IN	_	14	mark	_	_
9	I	i	NN	NN	_	12	compound	_	_
10	kappa	kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	14	nsubj	_	_
14	stay	stay	VBP	VBP	_	7	advcl	_	_
15	low	low	JJ	JJ	_	14	xcomp	_	_
16	for	for	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	prolonged	prolonged	JJ	JJ	_	19	amod	_	_
19	time	time	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	7	nsubjpass	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	several	several	JJ	JJ	_	10	amod	_	_
10	hours	hour	NNS	NNS	_	7	nmod	_	_
11	after	after	IN	IN	_	12	case	_	_
12	stimulation	stimulation	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	removal	removal	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	9	compound	_	_
8	containing	containing	NN	NN	_	9	compound	_	_
9	medium	medium	NN	NN	_	4	nmod	_	_
10	causes	cause	VBZ	VBZ	_	2	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	rapid	rapid	JJ	JJ	_	13	amod	_	_
13	decrease	decrease	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	phosphoform	phosphoform	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	newly	newly	RB	RB	_	5	advmod	_	_
5	synthesized	synthesize	VBN	VBN	_	9	amod	_	_
6	I	i	NN	NN	_	9	compound	_	_
7	kappa	kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	alpha	alpha	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	visible	visible	JJ	JJ	_	0	root	_	_
12	when	when	WRB	WRB	_	18	advmod	_	_
13	degradation	degradation	NN	NN	_	18	nsubjpass	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	proteasome	proteasome	NN	NN	_	13	nmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	inhibited	inhibit	VBN	VBN	_	11	advcl	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	new	new	JJ	JJ	_	24	amod	_	_
21	I	i	NN	NN	_	24	compound	_	_
22	kappa	kappa	NN	NN	_	24	compound	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	alpha	alpha	NN	NN	_	25	nsubj	_	_
25	displays	display	VBZ	VBZ	_	11	conj	_	_
26	the	the	DT	DT	_	28	det	_	_
27	same	same	JJ	JJ	_	28	amod	_	_
28	properties	property	NNS	NNS	_	25	dobj	_	_
29	regarding	regard	VBG	VBG	_	30	case	_	_
30	phosphorylation	phosphorylation	NN	NN	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	degradation	degradation	NN	NN	_	30	conj	_	_
33	in	in	IN	IN	_	34	case	_	_
34	response	response	NN	NN	_	30	nmod	_	_
35	to	to	TO	TO	_	38	case	_	_
36	a	a	DT	DT	_	38	det	_	_
37	second	second	JJ	JJ	_	38	amod	_	_
38	inducer	inducer	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	significant	significant	JJ	JJ	_	5	amod	_	_
5	difference	difference	NN	NN	_	2	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	turnover	turnover	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	pre-	pre-	JJ	JJ	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	post-inductive	post-inductive	JJ	JJ	_	10	conj	_	_
13	I	i	NN	NN	_	16	compound	_	_
14	kappa	kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	10	dep	_	_
17	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	resynthesis	resynthesis	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	kappa	kappa	NN	NN	_	10	compound	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	removal	removal	NN	NN	_	5	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	stimulus	stimulus	NN	NN	_	12	nmod	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	obligatory	obligatory	JJ	JJ	_	18	amod	_	_
18	steps	step	NNS	NNS	_	3	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	inactivation	inactivation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
24	NF	nf	NN	NN	_	26	compound	_	_
25	kappa	kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
2	B/Rel	b/rel	NN	NN	_	4	compound	_	_
3	family	family	NN	NN	_	4	compound	_	_
4	members	member	NNS	NNS	_	0	root	_	_
5	regulating	regulate	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	ICAM-1	icam-1	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
11	THP-1	thp-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	kappa	kappa	NN	NN	_	3	compound	_	_
3	B-site	b-site	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	promoter	promoter	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	17	case	_	_
10	the	the	DT	DT	_	17	det	_	_
11	intercellular	intercellular	JJ	JJ	_	17	amod	_	_
12	adhesion	adhesion	NN	NN	_	17	compound	_	_
13	molecule-1	molecule-1	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	ICAM-1	icam-1	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	gene	gene	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	involved	involve	VBN	VBN	_	5	dep	_	_
22	in	in	IN	IN	_	23	case	_	_
23	regulation	regulation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	ICAM-1	icam-1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	by	by	IN	IN	_	31	case	_	_
28	tumor	tumor	NN	NN	_	31	compound	_	_
29	necrosis	necrosis	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	23	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	TNF-alpha	tnf-alpha	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	glucocorticoids	glucocorticoid	NNS	NNS	_	31	conj	_	_
37	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	on	on	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	3	nmod	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	bind	bind	VBP	VBP	_	7	acl:relcl	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	transactivate	transactivate	VBP	VBP	_	9	conj	_	_
12	this	this	DT	DT	_	14	det	_	_
13	enhancer	enhancer	NN	NN	_	14	compound	_	_
14	sequence	sequence	NN	NN	_	9	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vitro	vitro	FW	FW	_	9	advmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	8	det	_	_
5	ICAM-1	icam-1	NN	NN	_	8	compound	_	_
6	kappa	kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	site	site	NN	NN	_	9	nsubj	_	_
9	appeared	appear	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	bind	bind	VB	VB	_	9	xcomp	_	_
12	RelA	rela	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	c-Rel	c-rel	NN	NN	_	15	compound	_	_
15	homodimers	homodimer	NNS	NNS	_	12	conj	_	_
16	as	as	RB	RB	_	12	cc	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	as	as	IN	IN	_	16	mwe	_	_
19	heterodimers	heterodimer	NNS	NNS	_	12	conj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
22	B1	b1	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	11	punct	_	_
24	but	but	CC	CC	_	11	cc	_	_
25	weakly	weakly	RB	RB	_	28	advmod	_	_
26	NF-kappa	nf-kappa	NN	NN	_	28	compound	_	_
27	B1	b1	NN	NN	_	28	compound	_	_
28	homodimers	homodimer	NNS	NNS	_	11	conj	_	_
29	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	RelA	rela	NN	NN	_	15	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-Rel	c-rel	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	5	cc	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B1	b1	NN	NN	_	5	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	transactivate	transactivate	VB	VB	_	15	xcomp	_	_
18	an	a	DT	DT	_	22	det	_	_
19	ICAM-1	icam-1	NN	NN	_	22	compound	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B-reporter	b-reporter	JJ	JJ	_	22	amod	_	_
22	construct	construct	NN	NN	_	17	dobj	_	_
23	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	monocytic	monocytic	JJ	JJ	_	4	amod	_	_
3	THP-1	thp-1	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nmod	_	_
5	TNF-alpha	tnf-alpha	NN	NN	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	6	dobj	_	_
10	which	which	WDT	WDT	_	13	nsubj	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	13	advmod	_	_
13	bound	bind	VBD	VBD	_	9	acl:relcl	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	ICAM-1	icam-1	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	antibodies	antibody	NNS	NNS	_	1	dobj	_	_
3	in	in	IN	IN	_	8	case	_	_
4	an	a	DT	DT	_	8	det	_	_
5	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
6	mobility	mobility	NN	NN	_	8	compound	_	_
7	supershift	supershift	NN	NN	_	8	compound	_	_
8	assay	assay	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	one	one	CD	CD	_	15	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	these	these	DT	DT	_	13	det	_	_
13	complexes	complex	NNS	NNS	_	10	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	1	parataxis	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	contain	contain	VB	VB	_	15	ccomp	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B1	b1	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	RelA	rela	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	bind	bind	VB	VB	_	17	conj	_	_
26	with	with	IN	IN	_	28	case	_	_
27	higher	higher	JJR	JJR	_	28	amod	_	_
28	affinity	affinity	NN	NN	_	25	nmod	_	_
29	to	to	TO	TO	_	34	case	_	_
30	the	the	DT	DT	_	34	det	_	_
31	consensus	consensus	NN	NN	_	34	compound	_	_
32	kappa	kappa	NN	NN	_	34	compound	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	25	nmod	_	_
35	in	in	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	HIV	hiv	NN	NN	_	40	compound	_	_
38	long	long	JJ	JJ	_	40	amod	_	_
39	terminal	terminal	JJ	JJ	_	40	amod	_	_
40	repeat	repeat	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	contained	contain	VBD	VBD	_	0	root	_	_
5	RelA	rela	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	4	punct	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	exhibited	exhibit	VBD	VBD	_	4	conj	_	_
9	higher	higher	JJR	JJR	_	10	amod	_	_
10	affinity	affinity	NN	NN	_	8	dobj	_	_
11	towards	towards	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	ICAM-1	icam-1	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	10	nmod	_	_
16	than	than	IN	IN	_	22	case	_	_
17	to	to	TO	TO	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	HIV	hiv	NN	NN	_	22	compound	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	10	acl	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	repress	repress	VB	VB	_	5	xcomp	_	_
8	activity	activity	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	both	both	CC	CC	_	13	cc:preconj	_	_
11	the	the	DT	DT	_	13	det	_	_
12	RelA	rela	NN	NN	_	13	compound	_	_
13	homodimer	homodimer	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	18	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	18	compound	_	_
17	B1/RelA	b1/rela	NN	NN	_	18	compound	_	_
18	heterodimer	heterodimer	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	argue	argue	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	in	in	FW	FW	_	5	compound	_	_
5	vivo	vivo	FW	FW	_	9	advmod	_	_
6	RelA	rela	NN	NN	_	7	compound	_	_
7	homodimers	homodimer	NNS	NNS	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	likely	likely	JJ	JJ	_	2	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	play	play	VB	VB	_	9	xcomp	_	_
12	a	a	DT	DT	_	14	det	_	_
13	dominant	dominant	JJ	JJ	_	14	amod	_	_
14	role	role	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	18	amod	_	_
17	ICAM-1	icam-1	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	11	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Inefficient	inefficient	JJ	JJ	_	2	amod	_	_
2	termination	termination	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	antigen	antigen	NN	NN	_	5	compound	_	_
5	responses	response	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	NF-ATp-deficient	nf-atp-deficient	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	elucidate	elucidate	VB	VB	_	34	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-ATp	nf-atp	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	one	one	CD	CD	_	8	appos	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	most	most	RBS	RBS	_	14	advmod	_	_
14	prominent	prominent	JJ	JJ	_	15	amod	_	_
15	members	member	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	family	family	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	NF-AT	nf-at	NN	NN	_	21	compound	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cell	cell	NN	NN	_	25	nmod	_	_
30	activation	activation	NN	NN	_	29	dep	_	_
31	and	and	CC	CC	_	29	cc	_	_
32	differentiation	differentiation	NN	NN	_	29	conj	_	_
33	we	we	PRP	PRP	_	34	nsubj	_	_
34	created	create	VBD	VBD	_	0	root	_	_
35	NF-ATp-deficient	nf-atp-deficient	JJ	JJ	_	36	amod	_	_
36	mice	mouse	NNS	NNS	_	34	dobj	_	_
37	by	by	IN	IN	_	38	case	_	_
38	gene	gene	NN	NN	_	34	nmod	_	_
39	targeting	target	VBG	VBG	_	38	amod	_	_
40	.	.	.	.	_	34	punct	_	_

1	Such	such	JJ	JJ	_	3	amod	_	_
2	NF-ATp-/-	nf-atp-/-	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	born	born	JJ	JJ	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	appear	appear	VBP	VBP	_	5	conj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	develop	develop	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	13	det	_	_
11	normal	normal	JJ	JJ	_	13	amod	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	9	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Apart	apart	RB	RB	_	50	advmod	_	_
2	from	from	IN	IN	_	4	case	_	_
3	clear-cut	clear-cut	JJ	JJ	_	4	amod	_	_
4	defects	defect	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	synthesis	synthesis	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	mRNAs	mrna	NNS	NNS	_	7	nmod	_	_
10	for	for	IN	IN	_	12	case	_	_
11	Th2-type	th2-type	JJ	JJ	_	12	amod	_	_
12	lymphokines	lymphokine	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	such	such	JJ	JJ	_	16	case	_	_
15	as	as	IN	IN	_	14	mwe	_	_
16	IL-4	il-4	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	IL-5	il-5	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	IL-10	il-10	NN	NN	_	16	conj	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	IL-13	il-13	NN	NN	_	16	conj	_	_
23	,	,	,	,	_	7	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	primary	primary	JJ	JJ	_	7	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	secondary	secondary	JJ	JJ	_	25	conj	_	_
28	stimulations	stimulation	NNS	NNS	_	25	dep	_	_
29	of	of	IN	IN	_	31	case	_	_
30	spleen	spleen	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	in	in	FW	FW	_	33	compound	_	_
33	vitro	vitro	FW	FW	_	25	advmod	_	_
34	,	,	,	,	_	50	punct	_	_
35	of	of	IN	IN	_	39	amod	_	_
36	a	a	DT	DT	_	39	det	_	_
37	distinct	distinct	JJ	JJ	_	39	amod	_	_
38	impaired	impaired	JJ	JJ	_	37	dep	_	_
39	deletion	deletion	NN	NN	_	50	nsubjpass	_	_
40	of	of	IN	IN	_	45	case	_	_
41	V	v	NN	NN	_	45	compound	_	_
42	beta	beta	NN	NN	_	45	compound	_	_
43	11+/CD4+	11+/cd4+	JJ	JJ	_	45	amod	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	lymphocytes	lymphocyte	NNS	NNS	_	39	nmod	_	_
46	from	from	IN	IN	_	48	case	_	_
47	these	these	DT	DT	_	48	det	_	_
48	mice	mouse	NNS	NNS	_	45	nmod	_	_
49	was	be	VBD	VBD	_	50	auxpass	_	_
50	detected	detect	VBN	VBN	_	0	root	_	_
51	after	after	IN	IN	_	53	case	_	_
52	superantigen	superantigen	NN	NN	_	53	compound	_	_
53	injection	injection	NN	NN	_	50	nmod	_	_
54	.	.	.	.	_	50	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	NF-ATp-/-	nf-atp-/-	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	9	nsubj	_	_
5	older	older	JJR	JJR	_	4	amod	_	_
6	than	than	IN	IN	_	8	case	_	_
7	6	6	CD	CD	_	8	nummod	_	_
8	weeks	week	NNS	NNS	_	5	nmod	_	_
9	show	show	VBP	VBP	_	0	root	_	_
10	an	a	DT	DT	_	13	det	_	_
11	2-5	2-5	CD	CD	_	12	compound	_	_
12	fold	fold	JJ	JJ	_	13	amod	_	_
13	increase	increase	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	number	number	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	correlated	correlate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	increased	increase	VBN	VBN	_	7	amod	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	activation	activation	NN	NN	_	10	compound	_	_
10	markers	marker	NNS	NNS	_	7	nmod	_	_
11	CD44	cd44	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CD69	cd69	NN	NN	_	11	conj	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	decreased	decrease	VBN	VBN	_	16	amod	_	_
16	expression	expression	NN	NN	_	7	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CD62	cd62	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	target	target	NN	NN	_	4	compound	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	lymphoid-specific	lymphoid-specific	JJ	JJ	_	10	amod	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	Oct2	oct2	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	Oct2	oct2	NN	NN	_	6	nsubjpass	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	2	dep	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	0	root	_	_
7	predominantly	predominantly	RB	RB	_	10	advmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	plays	play	VBZ	VBZ	_	6	conj	_	_
13	an	a	DT	DT	_	15	det	_	_
14	essential	essential	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	during	during	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	terminal	terminal	JJ	JJ	_	19	amod	_	_
19	phase	phase	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	B	b	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	regions	region	NNS	NNS	_	12	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	specifically	specifically	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	contain	contain	VBP	VBP	_	0	root	_	_
13	functional	functional	JJ	JJ	_	15	amod	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	sites	site	NNS	NNS	_	12	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	Oct2	oct2	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	none	none	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	originally	originally	RB	RB	_	8	advmod	_	_
8	thought	think	VBN	VBN	_	6	acl	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	8	xcomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Oct2	oct2	NN	NN	_	11	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	affected	affect	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	Oct2-deficient	oct2-deficient	JJ	JJ	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	attempt	attempt	NN	NN	_	25	nmod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	find	find	VB	VB	_	3	dep	_	_
6	such	such	JJ	JJ	_	7	amod	_	_
7	elusive	elusive	JJ	JJ	_	8	amod	_	_
8	Oct2	oct2	NN	NN	_	5	dobj	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	8	dep	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	understand	understand	VB	VB	_	5	conj	_	_
14	the	the	DT	DT	_	16	det	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	function	function	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Oct2	oct2	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	25	punct	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	isolated	isolate	VBD	VBD	_	0	root	_	_
26	cDNAs	cdna	NNS	NNS	_	25	dobj	_	_
27	for	for	IN	IN	_	28	case	_	_
28	Oct2	oct2	NN	NN	_	26	nmod	_	_
29	target	target	NN	NN	_	30	compound	_	_
30	genes	gene	NNS	NNS	_	28	dep	_	_
31	.	.	.	.	_	25	punct	_	_

1	So	so	RB	RB	_	2	advmod	_	_
2	far	far	RB	RB	_	6	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	five	five	CD	CD	_	9	nummod	_	_
8	potential	potential	JJ	JJ	_	9	amod	_	_
9	targets	target	NNS	NNS	_	6	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	Oct2	oct2	NN	NN	_	9	nmod	_	_
12	:	:	:	:	_	6	punct	_	_
13	the	the	DT	DT	_	15	det	_	_
14	membrane	membrane	NN	NN	_	15	compound	_	_
15	glycoprotein	glycoprotein	NN	NN	_	6	dep	_	_
16	CD36	cd36	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	15	punct	_	_
18	the	the	DT	DT	_	21	det	_	_
19	cysteine-rich	cysteine-rich	JJ	JJ	_	21	amod	_	_
20	secreted	secrete	VBN	VBN	_	21	amod	_	_
21	protein	protein	NN	NN	_	15	conj	_	_
22	3	3	CD	CD	_	21	nummod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CRISP-3	crisp-3	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	15	punct	_	_
27	a	a	DT	DT	_	29	det	_	_
28	mouse	mouse	NN	NN	_	29	compound	_	_
29	homolog	homolog	NN	NN	_	15	conj	_	_
30	of	of	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	human	human	JJ	JJ	_	35	amod	_	_
33	monocyte/neutrophil	monocyte/neutrophil	NN	NN	_	35	compound	_	_
34	elastase	elastase	NN	NN	_	35	compound	_	_
35	inhibitor	inhibitor	NN	NN	_	29	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	mEI	mei	NN	NN	_	29	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	and	and	CC	CC	_	15	cc	_	_
40	two	two	CD	CD	_	43	nummod	_	_
41	unknown	unknown	JJ	JJ	_	43	amod	_	_
42	cDNA	cdna	NN	NN	_	43	compound	_	_
43	sequences	sequence	NNS	NNS	_	15	conj	_	_
44	Nov1	nov1	NN	NN	_	43	dep	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	Nov2	nov2	NN	NN	_	44	conj	_	_
47	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	target	target	NN	NN	_	3	compound	_	_
3	genes	gene	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	quite	quite	RB	RB	_	6	advmod	_	_
6	distinct	distinct	JJ	JJ	_	8	amod	_	_
7	expression	expression	NN	NN	_	8	compound	_	_
8	patterns	pattern	NNS	NNS	_	4	dobj	_	_
9	demonstrating	demonstrate	VBG	VBG	_	8	acl	_	_
10	that	that	IN	IN	_	18	mark	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	18	nsubjpass	_	_
13	in	in	IN	IN	_	14	case	_	_
14	addition	addition	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	Oct2	oct2	NN	NN	_	14	nmod	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	involved	involve	VBN	VBN	_	9	ccomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	regulation	regulation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	CD36	cd36	NN	NN	_	6	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	mEI	mei	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	19	advcl	_	_
7	in	in	IN	IN	_	11	case	_	_
8	all	all	DT	DT	_	11	det	_	_
9	hematopoetic	hematopoetic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	6	nmod	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	Oct2	oct2	NN	NN	_	12	dobj	_	_
14	,	,	,	,	_	19	punct	_	_
15	.	.	.	.	_	19	punct	_	_
16	CRISP-3	crisp-3	NN	NN	_	19	nsubj	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	pre-B	pre-b	JJ	JJ	_	19	amod	_	_
19	cell-specific	cell-specific	JJ	JJ	_	0	root	_	_
20	,	,	,	,	_	19	punct	_	_
21	Nov1	nov1	NN	NN	_	25	nsubj	_	_
22	is	be	VBZ	VBZ	_	25	cop	_	_
23	plasma	plasma	NN	NN	_	25	nmod:npmod	_	_
24	B	b	NN	NN	_	25	nmod:npmod	_	_
25	cell-specific	cell-specific	JJ	JJ	_	19	conj	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	Nov2	nov2	NN	NN	_	31	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	31	auxpass	_	_
29	B	b	NN	NN	_	30	dep	_	_
30	cell-specifically	cell-specifically	RB	RB	_	31	advmod	_	_
31	expressed	express	VBN	VBN	_	19	conj	_	_
32	.	.	.	.	_	19	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Molecular-biologic	molecular-biologic	JJ	JJ	_	3	amod	_	_
3	aspects	aspect	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	interaction	interaction	NN	NN	_	3	nmod	_	_
6	between	between	IN	IN	_	7	case	_	_
7	nervous	nervous	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immune	immune	JJ	JJ	_	7	conj	_	_
10	systems	system	NNS	NNS	_	7	dep	_	_
11	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	problem	problem	NN	NN	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	neuro-immuno	neuro-immuno	JJ	JJ	_	6	amod	_	_
6	interactions	interaction	NNS	NNS	_	2	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	level	level	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	trans-factors	trans-factor	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	stimulating	stimulate	VBG	VBG	_	6	acl	_	_
16	interleukin-2	interleukin-2	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	IL-2	il-2	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	15	dobj	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	discussed	discuss	VBN	VBN	_	0	root	_	_
24	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	physico-chemical	physico-chemical	JJ	JJ	_	32	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	functional	functional	JJ	JJ	_	2	conj	_	_
5	parameters	parameter	NNS	NNS	_	2	dep	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	low	low	JJ	JJ	_	11	amod	_	_
9	molecular	molecular	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	2	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	SP	sp	NN	NN	_	11	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	BP-14	bp-14	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	15	punct	_	_
17	18	18	CD	CD	_	15	amod	_	_
18	,	,	,	,	_	15	punct	_	_
19	19	19	CD	CD	_	15	amod	_	_
20	kDs	kd	NNS	NNS	_	15	dep	_	_
21	)	)	-RRB-	-RRB-	_	13	punct	_	_
22	isolated	isolate	VBN	VBN	_	11	acl	_	_
23	from	from	IN	IN	_	24	case	_	_
24	splenic	splenic	JJ	JJ	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	brain	brain	NN	NN	_	24	conj	_	_
27	cells	cell	NNS	NNS	_	24	dep	_	_
28	of	of	IN	IN	_	30	case	_	_
29	immunized	immunized	JJ	JJ	_	30	amod	_	_
30	rats	rat	NNS	NNS	_	24	nmod	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	studied	study	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	30	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	9	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	2	advmod	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	stimulation	stimulation	NN	NN	_	2	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-2mRNA	il-2mrna	NN	NN	_	20	compound	_	_
20	synthesis	synthesis	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	splenic	splenic	JJ	JJ	_	25	amod	_	_
23	T-	t-	NN	NN	_	25	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	25	compound	_	_
25	culture	culture	NN	NN	_	16	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	normal	normal	JJ	JJ	_	28	amod	_	_
28	conditions	condition	NNS	NNS	_	25	nmod	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	shown	show	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	protective	protective	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	24	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	SP	sp	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	BP	bp	NN	NN	_	5	conj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2mRNA	il-2mrna	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	3	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	stressful	stressful	JJ	JJ	_	14	amod	_	_
14	conditions	condition	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	T-cells	t-cell	NNS	NNS	_	19	compound	_	_
19	treatment	treatment	NN	NN	_	14	conj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	CsA	csa	NN	NN	_	19	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Endothelial	endothelial	JJ	JJ	_	2	amod	_	_
2	production	production	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	MCP-1	mcp-1	NN	NN	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	modulation	modulation	NN	NN	_	2	dep	_	_
7	by	by	IN	IN	_	8	case	_	_
8	heparin	heparin	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	consequences	consequence	NNS	NNS	_	6	conj	_	_
11	for	for	IN	IN	_	14	case	_	_
12	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Heparin	heparin	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	polyanionic	polyanionic	JJ	JJ	_	5	amod	_	_
5	glycosaminoglycan	glycosaminoglycan	NN	NN	_	0	root	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	GAG	gag	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	bind	bind	VB	VB	_	5	acl:relcl	_	_
12	with	with	IN	IN	_	14	case	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	affinity	affinity	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	range	range	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cytokines	cytokine	NNS	NNS	_	17	nmod	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	interferon-gamma	interferon-gamma	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	members	member	NNS	NNS	_	17	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	chemokine	chemokine	NN	NN	_	30	compound	_	_
30	superfamily	superfamily	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	GAG	gag	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	possesses	possess	VBZ	VBZ	_	0	root	_	_
5	immunomodulatory	immunomodulatory	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	in	in	FW	FW	_	6	amod	_	_
8	vivo	vivo	FW	FW	_	7	dep	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	antagonize	antagonize	VB	VB	_	4	conj	_	_
12	the	the	DT	DT	_	13	det	_	_
13	capacity	capacity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	induce	induce	VB	VB	_	13	dep	_	_
18	class	class	NN	NN	_	21	compound	_	_
19	II	ii	CD	CD	_	21	nummod	_	_
20	MHC	mhc	NN	NN	_	21	compound	_	_
21	antigen	antigen	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	17	dobj	_	_
23	,	,	,	,	_	17	punct	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	up-regulate	up-regulate	VBP	VBP	_	17	conj	_	_
27	intercellular	intercellular	JJ	JJ	_	29	amod	_	_
28	adhesion	adhesion	NN	NN	_	29	compound	_	_
29	molecule-1	molecule-1	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	11	punct	_	_
31	by	by	IN	IN	_	34	case	_	_
32	cultured	culture	VBN	VBN	_	34	amod	_	_
33	endothelial	endothelial	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	11	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	binding	binding	NN	NN	_	12	nsubj	_	_
7	to	to	TO	TO	_	10	case	_	_
8	cell-surface	cell-surface	JJ	JJ	_	10	amod	_	_
9	heparan	heparan	NN	NN	_	10	compound	_	_
10	sulphate	sulphate	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	essential	essential	JJ	JJ	_	4	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	optimal	optimal	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	that	that	IN	IN	_	23	mark	_	_
20	free	free	JJ	JJ	_	21	amod	_	_
21	heparin	heparin	NN	NN	_	23	nsubj	_	_
22	competitively	competitively	RB	RB	_	23	advmod	_	_
23	inhibits	inhibit	VBZ	VBZ	_	12	conj	_	_
24	this	this	DT	DT	_	26	det	_	_
25	sequestration	sequestration	NN	NN	_	26	compound	_	_
26	process	process	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	performed	perform	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	increase	increase	VB	VB	_	5	xcomp	_	_
8	our	we	PRP$	PRP$	_	9	nmod:poss	_	_
9	understanding	understanding	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	immunosuppressive	immunosuppressive	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	heparin	heparin	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	investigation	investigation	NN	NN	_	7	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	potential	potential	JJ	JJ	_	20	amod	_	_
20	antagonism	antagonism	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	production	production	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	function	function	NN	NN	_	23	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	monocyte	monocyte	NN	NN	_	29	compound	_	_
28	chemotactic	chemotactic	JJ	JJ	_	29	amod	_	_
29	peptide-1	peptide-1	NN	NN	_	23	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	MCP-1	mcp-1	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	29	punct	_	_
34	a	a	DT	DT	_	35	det	_	_
35	chemokine	chemokine	NN	NN	_	29	appos	_	_
36	important	important	JJ	JJ	_	35	amod	_	_
37	for	for	IN	IN	_	40	case	_	_
38	mononuclear	mononuclear	JJ	JJ	_	40	amod	_	_
39	leucocyte	leucocyte	NN	NN	_	40	compound	_	_
40	recruitment	recruitment	NN	NN	_	36	nmod	_	_
41	across	across	IN	IN	_	43	case	_	_
42	vascular	vascular	JJ	JJ	_	43	amod	_	_
43	endothelium	endothelium	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	mixture	mixture	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	heparin	heparin	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	5	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
11	up-regulation	up-regulation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	signal	signal	NN	NN	_	11	nmod	_	_
15	transducer	transducer	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	activator	activator	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	14	punct	_	_
22	STAT-1	stat-1	NN	NN	_	14	appos	_	_
23	produced	produce	VBN	VBN	_	14	acl	_	_
24	normally	normally	RB	RB	_	23	advmod	_	_
25	by	by	IN	IN	_	26	case	_	_
26	treatment	treatment	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	endothelial	endothelial	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	with	with	IN	IN	_	31	case	_	_
31	IFN-gamma	ifn-gamma	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	MCP-1	mcp-1	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	that	that	WDT	WDT	_	11	nsubjpass	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	specifically	specifically	RB	RB	_	11	advmod	_	_
11	caused	cause	VBN	VBN	_	7	dep	_	_
12	by	by	IN	IN	_	13	case	_	_
13	mixture	mixture	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	23	case	_	_
17	heparin-like	heparin-like	JJ	JJ	_	23	amod	_	_
18	,	,	,	,	_	17	punct	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	therefore	therefore	RB	RB	_	17	advmod	_	_
21	cytokine-binding	cytokine-binding	JJ	JJ	_	17	conj	_	_
22	,	,	,	,	_	23	punct	_	_
23	GAGs	gag	NNS	NNS	_	13	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	mixture	mixture	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	heparin-like	heparin-like	JJ	JJ	_	9	amod	_	_
9	GAGs	gag	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	MCP-1	mcp-1	NN	NN	_	6	nmod	_	_
12	inhibited	inhibit	VBD	VBD	_	4	ccomp	_	_
13	the	the	DT	DT	_	16	det	_	_
14	rapid	rapid	JJ	JJ	_	16	amod	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	12	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	phosphatidylinositol	phosphatidylinositol	NN	NN	_	19	compound	_	_
19	3-kinase	3-kinase	NN	NN	_	16	nmod	_	_
20	which	which	WDT	WDT	_	23	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	normally	normally	RB	RB	_	23	advmod	_	_
23	produced	produce	VBN	VBN	_	19	acl:relcl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	treatment	treatment	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	mononuclear	mononuclear	JJ	JJ	_	28	amod	_	_
28	leucocytes	leucocyte	NNS	NNS	_	25	nmod	_	_
29	with	with	IN	IN	_	31	case	_	_
30	this	this	DT	DT	_	31	det	_	_
31	chemokine	chemokine	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Blockade	blockade	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	this	this	DT	DT	_	6	det	_	_
4	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
5	signalling	signalling	NN	NN	_	6	compound	_	_
6	event	event	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	reduction	reduction	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	normal	normal	JJ	JJ	_	17	amod	_	_
15	transendothelial	transendothelial	JJ	JJ	_	17	amod	_	_
16	migration	migration	NN	NN	_	17	compound	_	_
17	response	response	NN	NN	_	11	nmod	_	_
18	towards	towards	IN	IN	_	19	case	_	_
19	MCP-1	mcp-1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Results	result	NNS	NNS	_	5	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	1	nmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	soluble	soluble	JJ	JJ	_	10	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	heparin-like	heparin-like	JJ	JJ	_	7	dep	_	_
10	GAGs	gag	NNS	NNS	_	12	nsubj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	block	block	VB	VB	_	5	ccomp	_	_
13	IFN-gamma-dependent	ifn-gamma-dependent	JJ	JJ	_	14	amod	_	_
14	up-regulation	up-regulation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	MCP-1	mcp-1	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	cultured	culture	VBN	VBN	_	21	amod	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	can	can	MD	MD	_	26	aux	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	antagonize	antagonize	VB	VB	_	12	conj	_	_
27	the	the	DT	DT	_	28	dep	_	_
28	leucocyte-activating	leucocyte-activating	JJ	JJ	_	26	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	migration-promoting	migration-promoting	JJ	JJ	_	28	conj	_	_
31	properties	property	NNS	NNS	_	28	dep	_	_
32	of	of	IN	IN	_	34	case	_	_
33	pre-existing	pre-existing	JJ	JJ	_	34	amod	_	_
34	MCP-1	mcp-1	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	activities	activity	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	contribute	contribute	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	immunomodulatory	immunomodulatory	JJ	JJ	_	8	amod	_	_
8	properties	property	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	heparin	heparin	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	interleukin-2	interleukin-2	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	alpha	alpha	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	beta	beta	NN	NN	_	9	conj	_	_
12	isoforms	isoform	NNS	NNS	_	1	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	glucocorticoid	glucocorticoid	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunosuppressive	immunosuppressive	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	glucocorticoids	glucocorticoid	NNS	NNS	_	3	nmod	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	largely	largely	RB	RB	_	8	advmod	_	_
8	due	due	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	immunologically	immunologically	RB	RB	_	15	advmod	_	_
14	relevant	relevant	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	such	such	JJ	JJ	_	24	case	_	_
18	as	as	IN	IN	_	17	mwe	_	_
19	the	the	DT	DT	_	24	det	_	_
20	interleukin-2	interleukin-2	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	IL-2	il-2	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	gene	gene	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GR	gr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	humans	human	NNS	NNS	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	alternative	alternative	JJ	JJ	_	5	amod	_	_
5	splicing	splicing	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	GR	gr	NN	NN	_	10	compound	_	_
9	precursor	precursor	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	5	nmod	_	_
11	gives	give	VBZ	VBZ	_	0	root	_	_
12	rise	rise	NN	NN	_	11	dobj	_	_
13	to	to	TO	TO	_	16	case	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	isoforms	isoform	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	termed	term	VBN	VBN	_	16	acl	_	_
19	GRalpha	gralpha	NN	NN	_	18	xcomp	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	GRbeta	grbeta	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	GRbeta	grbeta	NN	NN	_	7	nsubj	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	antagonize	antagonize	VB	VB	_	3	ccomp	_	_
8	GRalpha-mediated	gralpha-mediated	JJ	JJ	_	9	amod	_	_
9	transactivation	transactivation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	20	case	_	_
11	a	a	DT	DT	_	20	det	_	_
12	glucocorticoid-	glucocorticoid-	NN	NN	_	20	compound	_	_
13	responsive	responsive	JJ	JJ	_	20	amod	_	_
14	element	element	NN	NN	_	20	compound	_	_
15	(	(	-LRB-	-LRB-	_	20	punct	_	_
16	GRE	gre	NN	NN	_	20	compound	_	_
17	)	)	-RRB-	-RRB-	_	20	punct	_	_
18	-driven	-driven	JJ	JJ	_	20	amod	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	9	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	COS-7	cos-7	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	9	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	designed	design	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	analyze	analyze	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	roles	role	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	GR	gr	NN	NN	_	14	compound	_	_
14	isoforms	isoform	NNS	NNS	_	9	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	17	amod	_	_
17	transrepression	transrepression	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	a	a	DT	DT	_	6	det	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	developed	develop	VBN	VBN	_	6	amod	_	_
5	transfection	transfection	NN	NN	_	6	compound	_	_
6	technique	technique	NN	NN	_	1	dobj	_	_
7	,	,	,	,	_	1	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	demonstrate	demonstrate	VBP	VBP	_	1	parataxis	_	_
10	that	that	IN	IN	_	32	mark	_	_
11	in	in	IN	IN	_	14	case	_	_
12	primary	primary	JJ	JJ	_	14	amod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	32	nmod	_	_
15	,	,	,	,	_	32	punct	_	_
16	stimulation	stimulation	NN	NN	_	32	nsubjpass	_	_
17	of	of	IN	IN	_	24	case	_	_
18	a	a	DT	DT	_	24	det	_	_
19	548	548	CD	CD	_	24	nummod	_	_
20	bp	bp	NN	NN	_	24	compound	_	_
21	IL-2	il-2	NN	NN	_	24	compound	_	_
22	promoter-luciferase	promoter-luciferase	JJ	JJ	_	24	amod	_	_
23	reporter	reporter	NN	NN	_	24	compound	_	_
24	construct	construct	NN	NN	_	16	nmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	phorbol	phorbol	NN	NN	_	27	compound	_	_
27	ester	ester	NN	NN	_	16	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	calcium	calcium	NN	NN	_	30	compound	_	_
30	ionophore	ionophore	NN	NN	_	27	conj	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	reversed	reverse	VBN	VBN	_	9	ccomp	_	_
33	by	by	IN	IN	_	34	case	_	_
34	dexamethasone	dexamethasone	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	38	case	_	_
36	a	a	DT	DT	_	38	det	_	_
37	similar	similar	JJ	JJ	_	38	amod	_	_
38	extent	extent	NN	NN	_	32	nmod	_	_
39	as	as	IN	IN	_	44	case	_	_
40	in	in	IN	IN	_	44	case	_	_
41	Jurkat	jurkat	NN	NN	_	44	compound	_	_
42	T	t	NN	NN	_	44	compound	_	_
43	lymphoma	lymphoma	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	38	nmod	_	_
45	transfected	transfect	VBN	VBN	_	44	acl	_	_
46	with	with	IN	IN	_	50	case	_	_
47	a	a	DT	DT	_	50	det	_	_
48	GRalpha	gralpha	NN	NN	_	50	compound	_	_
49	expression	expression	NN	NN	_	50	compound	_	_
50	vector	vector	NN	NN	_	45	nmod	_	_
51	.	.	.	.	_	1	punct	_	_

1	Transfection	transfection	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	GRbeta	grbeta	NN	NN	_	6	compound	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	vector	vector	NN	NN	_	1	nmod	_	_
7	alone	alone	RB	RB	_	6	advmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	result	result	VB	VB	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	repression	repression	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	response	response	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	glucocorticoids	glucocorticoid	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	GRbeta	grbeta	NN	NN	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	antagonize	antagonize	VB	VB	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	repressive	repressive	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	GRalpha	gralpha	NN	NN	_	9	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	overexpression	overexpression	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	GRbeta	grbeta	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Jurkat	jurkat	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	cause	cause	VB	VB	_	0	root	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	inhibition	inhibition	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	GRalpha-induced	gralpha-induced	JJ	JJ	_	16	amod	_	_
16	transactivation	transactivation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	GRE-dependent	gre-dependent	JJ	JJ	_	22	amod	_	_
20	luciferase	luciferase	NN	NN	_	22	compound	_	_
21	reporter	reporter	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	16	nmod	_	_
23	either	either	RB	RB	_	11	advmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transrepressive	transrepressive	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nmod	_	_
9	on	on	IN	IN	_	12	case	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	6	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	exclusively	exclusively	RB	RB	_	15	advmod	_	_
15	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	GRalpha	gralpha	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	GRbeta	grbeta	NN	NN	_	2	nsubj	_	_
2	can	can	MD	MD	_	0	root	_	_
3	neither	neither	CC	CC	_	2	dep	_	_
4	antagonize	antagonize	VB	VB	_	2	conj	_	_
5	GRalpha-mediated	gralpha-mediated	JJ	JJ	_	6	amod	_	_
6	transactivation	transactivation	NN	NN	_	4	dobj	_	_
7	nor	nor	CC	CC	_	6	cc	_	_
8	transrepression	transrepression	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Jurkat	jurkat	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	indicating	indicate	VBG	VBG	_	2	advcl	_	_
14	a	a	DT	DT	_	17	det	_	_
15	cell	cell	NN	NN	_	16	nmod:npmod	_	_
16	type-specific	type-specific	JJ	JJ	_	17	amod	_	_
17	pattern	pattern	NN	NN	_	13	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	GRbeta-mediated	grbeta-mediated	JJ	JJ	_	21	amod	_	_
20	antiglucocorticoid	antiglucocorticoid	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	cyclic	cyclic	JJ	JJ	_	7	amod	_	_
4	AMP	amp	NN	NN	_	7	compound	_	_
5	response	response	NN	NN	_	7	compound	_	_
6	element-binding	element-binding	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	cyclic	cyclic	JJ	JJ	_	11	amod	_	_
10	AMP	amp	NN	NN	_	11	compound	_	_
11	inhibition	inhibition	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	14	amod	_	_
14	transcription	transcription	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	regulates	regulate	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	10	det	_	_
9	inducible	inducible	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	variety	variety	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	genes	gene	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	elevation	elevation	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
9	cyclic	cyclic	JJ	JJ	_	10	amod	_	_
10	AMP	amp	NN	NN	_	6	nmod	_	_
11	inhibits	inhibit	VBZ	VBZ	_	4	ccomp	_	_
12	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	endothelial	endothelial	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	conj	_	_
20	without	without	IN	IN	_	21	mark	_	_
21	preventing	prevent	VBG	VBG	_	11	advcl	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	translocation	translocation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
26	complexes	complex	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	inhibition	inhibition	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	activation	activation	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	A	a	NN	NN	_	11	compound	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	4	nmod	_	_
12	may	may	MD	MD	_	13	aux	_	_
13	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
14	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	phosphorylating	phosphorylate	VBG	VBG	_	13	advcl	_	_
18	proteins	protein	NNS	NNS	_	17	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	such	such	JJ	JJ	_	25	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	cAMP	camp	NN	NN	_	25	compound	_	_
23	response	response	NN	NN	_	25	compound	_	_
24	element-binding	element-binding	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	18	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CREB	creb	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	25	punct	_	_
30	which	which	WDT	WDT	_	31	nsubj	_	_
31	compete	compete	VBP	VBP	_	25	acl:relcl	_	_
32	for	for	IN	IN	_	34	case	_	_
33	limiting	limit	VBG	VBG	_	34	amod	_	_
34	amounts	amount	NNS	NNS	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	coactivator	coactivator	NN	NN	_	34	nmod	_	_
38	CBP	cbp	NN	NN	_	37	dep	_	_
39	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	amino-terminal	amino-terminal	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	17	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	amino	amino	NN	NN	_	11	compound	_	_
11	acids	acid	NNS	NNS	_	8	appos	_	_
12	1-450	1-450	CD	CD	_	11	nummod	_	_
13	)	)	-RRB-	-RRB-	_	11	punct	_	_
14	of	of	IN	IN	_	15	case	_	_
15	CBP	cbp	NN	NN	_	8	nmod	_	_
16	specifically	specifically	RB	RB	_	17	advmod	_	_
17	interacts	interact	VBZ	VBZ	_	4	ccomp	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	21	amod	_	_
21	region	region	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	amino	amino	NN	NN	_	24	compound	_	_
24	acids	acid	NNS	NNS	_	21	appos	_	_
25	286-551	286-551	CD	CD	_	24	nummod	_	_
26	)	)	-RRB-	-RRB-	_	24	punct	_	_
27	of	of	IN	IN	_	28	case	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	21	nmod	_	_
29	p65	p65	NN	NN	_	28	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	RelA	rela	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	both	both	CC	CC	_	36	cc:preconj	_	_
34	in	in	FW	FW	_	35	compound	_	_
35	vitro	vitro	FW	FW	_	36	advmod	_	_
36	and	and	CC	CC	_	17	advmod	_	_
37	in	in	FW	FW	_	38	compound	_	_
38	vivo	vivo	FW	FW	_	36	advmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	7	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	endothelial	endothelial	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	dobj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	overexpression	overexpression	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CBP	cbp	NN	NN	_	9	nmod	_	_
12	rescued	rescue	VBD	VBD	_	7	ccomp	_	_
13	cAMP	camp	NN	NN	_	14	compound	_	_
14	inhibition	inhibition	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	transcription	transcription	NN	NN	_	17	conj	_	_
20	mediated	mediate	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	chimeric	chimeric	JJ	JJ	_	24	amod	_	_
24	protein	protein	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	GAL4-p65	gal4-p65	NN	NN	_	24	appos	_	_
27	(	(	-LRB-	-LRB-	_	26	punct	_	_
28	286-551	286-551	CD	CD	_	26	nummod	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	,	,	,	,	_	24	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	contained	contain	VBD	VBD	_	24	acl:relcl	_	_
33	the	the	DT	DT	_	37	det	_	_
34	GAL4	gal4	NN	NN	_	37	compound	_	_
35	DNA	dna	NN	NN	_	37	compound	_	_
36	binding	binding	NN	NN	_	37	compound	_	_
37	domain	domain	NN	NN	_	32	dobj	_	_
38	fused	fuse	VBN	VBN	_	37	acl	_	_
39	to	to	TO	TO	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	42	amod	_	_
42	region	region	NN	NN	_	38	nmod	_	_
43	of	of	IN	IN	_	44	case	_	_
44	p65	p65	NN	NN	_	42	nmod	_	_
45	(	(	-LRB-	-LRB-	_	47	punct	_	_
46	amino	amino	NN	NN	_	47	compound	_	_
47	acids	acid	NNS	NNS	_	42	appos	_	_
48	286-551	286-551	CD	CD	_	47	nummod	_	_
49	)	)	-RRB-	-RRB-	_	47	punct	_	_
50	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	overexpression	overexpression	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CREB	creb	NN	NN	_	4	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	GAL4-p65(286-551)-mediated	gal4-p65(286-551)-mediated	JJ	JJ	_	9	amod	_	_
9	transcription	transcription	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	activation	activation	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	5	nmod	_	_
12	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	phosphorylating	phosphorylate	VBG	VBG	_	12	advcl	_	_
17	CREB	creb	NN	NN	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	competes	compete	VBZ	VBZ	_	17	acl:relcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	p65	p65	NN	NN	_	20	nmod	_	_
23	for	for	IN	IN	_	25	case	_	_
24	limiting	limit	VBG	VBG	_	25	amod	_	_
25	amounts	amount	NNS	NNS	_	20	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	CBP	cbp	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DNA-binding	dna-binding	NN	NN	_	5	compound	_	_
5	activities	activity	NNS	NNS	_	2	nmod	_	_
6	following	follow	VBG	VBG	_	8	case	_	_
7	CD19	cd19	NN	NN	_	8	compound	_	_
8	cross-linking	cross-linking	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	lineage	lineage	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	B	b	NN	NN	_	6	compound	_	_
3	cell-specific	cell-specific	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	surface	surface	NN	NN	_	6	compound	_	_
6	molecule	molecule	NN	NN	_	9	nsubjpass	_	_
7	CD19	cd19	NN	NN	_	6	dep	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	at	at	IN	IN	_	12	case	_	_
11	all	all	DT	DT	_	12	det	_	_
12	stages	stage	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	development	development	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	21	case	_	_
19	normal	normal	JJ	JJ	_	21	amod	_	_
20	plasma	plasma	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	mediates	mediate	VBZ	VBZ	_	9	conj	_	_
25	signal	signal	NN	NN	_	26	compound	_	_
26	transduction	transduction	NN	NN	_	24	dobj	_	_
27	via	via	IN	IN	_	28	case	_	_
28	interaction	interaction	NN	NN	_	24	nmod	_	_
29	with	with	IN	IN	_	32	case	_	_
30	cytoplasmic	cytoplasmic	JJ	JJ	_	32	amod	_	_
31	effector	effector	NN	NN	_	32	compound	_	_
32	proteins	protein	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	Cross-linking	cross-link	VBG	VBG	_	9	csubj	_	_
2	CD19	cd19	NN	NN	_	1	dobj	_	_
3	on	on	IN	IN	_	8	case	_	_
4	early	early	JJ	JJ	_	8	amod	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	B	b	NN	NN	_	8	compound	_	_
7	lineage	lineage	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	1	nmod	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	formation	formation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	CD19/Vav/phosphatidylinositol-3	cd19/vav/phosphatidylinositol-3	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	11	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CD19	cd19	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	Vav	vav	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	11	punct	_	_
25	and	and	CC	CC	_	11	cc	_	_
26	activation	activation	NN	NN	_	11	conj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	Ras	ras	NN	NN	_	30	compound	_	_
30	pathway	pathway	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	explore	explore	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ramifications	ramification	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	CD19	cd19	NN	NN	_	8	compound	_	_
8	signaling	signaling	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	current	current	JJ	JJ	_	12	amod	_	_
12	study	study	NN	NN	_	13	nsubj	_	_
13	examined	examine	VBD	VBD	_	3	parataxis	_	_
14	whether	whether	IN	IN	_	37	mark	_	_
15	phosphorylation	phosphorylation	NN	NN	_	37	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Elk-1	elk-1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	activation	activation	NN	NN	_	15	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	activator	activator	NN	NN	_	22	compound	_	_
22	protein-1	protein-1	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	AP-1	ap-1	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	15	punct	_	_
27	or	or	CC	CC	_	15	cc	_	_
28	activation	activation	NN	NN	_	15	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	factor-kappaB	factor-kappab	NN	NN	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	31	dep	_	_
37	occurred	occur	VBD	VBD	_	13	ccomp	_	_
38	following	follow	VBG	VBG	_	40	case	_	_
39	CD19	cd19	NN	NN	_	40	compound	_	_
40	cross-linking	cross-linking	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	9	nsubj	_	_
3	used	use	VBN	VBN	_	2	acl	_	_
4	were	be	VBD	VBD	_	9	cop	_	_
5	the	the	DT	DT	_	9	det	_	_
6	BLIN-1	blin-1	NN	NN	_	9	compound	_	_
7	pre-B	pre-b	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	0	root	_	_
10	expressing	express	VBG	VBG	_	9	acl	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	cell	cell	NN	NN	_	18	compound	_	_
15	surface	surface	NN	NN	_	18	compound	_	_
16	mu	mu	NN	NN	_	18	compound	_	_
17	heavy	heavy	JJ	JJ	_	18	amod	_	_
18	chain	chain	NN	NN	_	12	nmod	_	_
19	associated	associate	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	surrogate	surrogate	NN	NN	_	23	compound	_	_
22	light	light	NN	NN	_	23	compound	_	_
23	chain	chain	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	the	the	DT	DT	_	30	det	_	_
26	1E8	1e8	NN	NN	_	30	compound	_	_
27	immature	immature	JJ	JJ	_	30	amod	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	9	conj	_	_
31	expressing	express	VBG	VBG	_	30	acl	_	_
32	cell	cell	NN	NN	_	34	compound	_	_
33	surface	surface	NN	NN	_	34	compound	_	_
34	mu/kappa	mu/kappa	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	9	punct	_	_

1	Lysates	lysate	NNS	NNS	_	7	nsubj	_	_
2	from	from	IN	IN	_	3	case	_	_
3	CD19	cd19	NN	NN	_	1	nmod	_	_
4	cross-linked	cross-linked	JJ	JJ	_	3	amod	_	_
5	1E8	1e8	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	dep	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	robust	robust	JJ	JJ	_	9	amod	_	_
9	phosphorylation	phosphorylation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	Elk-1	elk-1	NN	NN	_	14	compound	_	_
13	fusion	fusion	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	9	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	7	advmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	whereas	whereas	IN	IN	_	25	mark	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	phosphorylation	phosphorylation	NN	NN	_	25	nsubj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	Elk-1	elk-1	NN	NN	_	24	compound	_	_
23	fusion	fusion	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	20	nmod	_	_
25	occurred	occur	VBD	VBD	_	7	advcl	_	_
26	using	use	VBG	VBG	_	25	xcomp	_	_
27	lysates	lysate	NNS	NNS	_	26	dobj	_	_
28	from	from	IN	IN	_	32	case	_	_
29	CD19	cd19	NN	NN	_	32	compound	_	_
30	cross-linked	cross-linked	JJ	JJ	_	32	amod	_	_
31	BLIN-1	blin-1	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	13	nsubjpass	_	_
6	employing	employ	VBG	VBG	_	5	acl	_	_
7	AP-1	ap-1	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	7	conj	_	_
10	consensus	consensus	NN	NN	_	11	compound	_	_
11	oligonucleotides	oligonucleotide	NNS	NNS	_	7	dep	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	used	use	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	demonstrate	demonstrate	VB	VB	_	13	xcomp	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	AP-1-binding	ap-1-binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	19	nsubj	_	_
19	increased	increase	VBD	VBD	_	15	ccomp	_	_
20	,	,	,	,	_	19	punct	_	_
21	while	while	IN	IN	_	27	mark	_	_
22	constitutive	constitutive	JJ	JJ	_	24	amod	_	_
23	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	24	amod	_	_
24	activity	activity	NN	NN	_	27	nsubjpass	_	_
25	was	be	VBD	VBD	_	27	auxpass	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	enhanced	enhance	VBN	VBN	_	19	advcl	_	_
28	,	,	,	,	_	27	punct	_	_
29	following	follow	VBG	VBG	_	31	case	_	_
30	2	2	CD	CD	_	31	nummod	_	_
31	h	h	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	CD19	cd19	NN	NN	_	34	compound	_	_
34	cross-linking	cross-linking	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	1E8	1e8	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	Supershift	supershift	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	JunD	jund	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	c-Fos	c-fos	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	conj	_	_
9	mediated	mediate	VBD	VBD	_	3	ccomp	_	_
10	anti-CD19	anti-cd19	NN	NN	_	13	compound	_	_
11	induced	induced	JJ	JJ	_	13	amod	_	_
12	AP-1-binding	ap-1-binding	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	1E8	1e8	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	CD19	cd19	NN	NN	_	5	compound	_	_
5	cross-linking	cross-linking	NN	NN	_	9	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	BLIN-1	blin-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	induction	induction	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	but	but	CC	CC	_	9	cc	_	_
17	had	have	VBD	VBD	_	9	conj	_	_
18	no	no	RB	RB	_	20	neg	_	_
19	apparent	apparent	JJ	JJ	_	20	amod	_	_
20	effect	effect	NN	NN	_	17	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	AP-1-binding	ap-1-binding	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	CD19-mediated	cd19-mediated	JJ	JJ	_	7	amod	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transduction	transduction	NN	NN	_	8	nsubj	_	_
8	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factors	NN	NN	_	8	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	juxtaposed	juxtapose	VBN	VBN	_	14	amod	_	_
14	stages	stage	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	development	development	NN	NN	_	14	nmod	_	_
19	that	that	IN	IN	_	21	nsubj	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	culminate	culminate	VB	VB	_	18	acl:relcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	dep	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	suppression	suppression	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	distinct	distinct	JJ	JJ	_	29	amod	_	_
29	sets	set	NNS	NNS	_	24	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	genes	gene	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-10	il-10	NN	NN	_	1	conj	_	_
4	inhibit	inhibit	VBP	VBP	_	0	root	_	_
5	induction	induction	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	IL-1	il-1	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	5	nmod	_	_
9	type	type	NN	NN	_	8	dep	_	_
10	I	i	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	type	type	NN	NN	_	8	conj	_	_
13	II	ii	CD	CD	_	12	nummod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	8	dep	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IL-4	il-4	NN	NN	_	5	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-13	il-13	NN	NN	_	17	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Th2-type	th2-type	JJ	JJ	_	3	amod	_	_
3	cytokines	cytokine	NNS	NNS	_	7	nsubj	_	_
4	IL-4	il-4	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-13	il-13	NN	NN	_	4	conj	_	_
7	induce	induce	VBP	VBP	_	0	root	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	distinct	distinct	JJ	JJ	_	12	amod	_	_
12	subset	subset	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	genes	gene	NNS	NNS	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	include	include	VBP	VBP	_	0	root	_	_
3	Fc	fc	NN	NN	_	4	compound	_	_
4	epsilonRII	epsilonrii	NN	NN	_	2	dobj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CD23	cd23	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	15-lipoxygenase	15-lipoxygenase	NN	NN	_	4	conj	_	_
10	,	,	,	,	_	4	punct	_	_
11	IL-1	il-1	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	antagonist	antagonist	NN	NN	_	4	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL-1ra	il-1ra	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	4	punct	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	type	type	NN	NN	_	4	conj	_	_
20	I	i	CD	CD	_	19	nummod	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	type	type	NN	NN	_	19	conj	_	_
23	II	ii	CD	CD	_	22	nummod	_	_
24	IL-1	il-1	NN	NN	_	25	compound	_	_
25	receptors	receptor	NNS	NNS	_	19	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IL-1R	il-1r	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	2	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	4	xcomp	_	_
7	induction	induction	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CD23	cd23	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	15-lipoxygenase	15-lipoxygenase	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
14	;	;	:	:	_	4	punct	_	_
15	however	however	RB	RB	_	33	advmod	_	_
16	,	,	,	,	_	33	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effects	effect	NNS	NNS	_	33	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	18	nmod	_	_
21	on	on	IN	IN	_	22	case	_	_
22	type	type	NN	NN	_	18	nmod	_	_
23	I	i	CD	CD	_	22	nummod	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	type	type	NN	NN	_	22	conj	_	_
26	II	ii	CD	CD	_	25	nummod	_	_
27	IL-1R	il-1r	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	22	dep	_	_
30	have	have	VBP	VBP	_	33	aux	_	_
31	not	not	RB	RB	_	33	neg	_	_
32	been	be	VBN	VBN	_	33	auxpass	_	_
33	defined	define	VBN	VBN	_	4	parataxis	_	_
34	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	basal	basal	JJ	JJ	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-4/IL-13-induced	il-4/il-13-induced	JJ	JJ	_	9	conj	_	_
12	IL-1R	il-1r	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	9	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	IL-4	il-4	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-13	il-13	NN	NN	_	1	conj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	dose-	dose-	NN	NN	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	time-dependent	time-dependent	JJ	JJ	_	5	conj	_	_
8	increases	increase	NNS	NNS	_	4	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	IL-1RI	il-1ri	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-1RII	il-1rii	NN	NN	_	10	conj	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	10	dep	_	_
15	.	.	.	.	_	4	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	nsubj	_	_
2	decreased	decrease	VBD	VBD	_	0	root	_	_
3	basal	basal	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	as	as	RB	RB	_	4	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	4	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	genes	gene	NNS	NNS	_	4	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	IL-4	il-4	NN	NN	_	4	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-13	il-13	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	Inhibition	inhibition	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-1RI	il-1ri	JJ	JJ	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-1RII	il-1rii	NN	NN	_	3	conj	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	3	dep	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	transcriptionally	transcriptionally	RB	RB	_	12	advmod	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	correlated	correlate	VBN	VBN	_	12	conj	_	_
16	directly	directly	RB	RB	_	15	advmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	decreased	decrease	VBN	VBN	_	19	amod	_	_
19	production	production	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	soluble	soluble	JJ	JJ	_	22	amod	_	_
22	IL-1RII	il-1rii	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	14	nsubj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	suppress	suppress	VB	VB	_	4	acl	_	_
7	IL-1RI	il-1ri	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-1RII	il-1rii	NN	NN	_	7	conj	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	7	dep	_	_
12	was	be	VBD	VBD	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	unique	unique	JJ	JJ	_	0	root	_	_
15	to	to	TO	TO	_	16	case	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	14	nmod	_	_
17	because	because	IN	IN	_	20	mark	_	_
18	IL-10	il-10	NN	NN	_	20	nsubj	_	_
19	also	also	RB	RB	_	20	advmod	_	_
20	inhibited	inhibit	VBD	VBD	_	14	advcl	_	_
21	expression	expression	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	genes	gene	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	IL-4/IL-13-stimulated	il-4/il-13-stimulated	JJ	JJ	_	27	amod	_	_
27	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	Inhibition	inhibition	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IL-1R	il-1r	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	due	due	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	down-regulation	down-regulation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	surface	surface	NN	NN	_	17	compound	_	_
17	IL-4R	il-4r	NN	NN	_	14	nmod	_	_
18	because	because	IN	IN	_	25	mark	_	_
19	pretreatment	pretreatment	NN	NN	_	25	nsubj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	these	these	DT	DT	_	22	det	_	_
22	cytokines	cytokine	NNS	NNS	_	19	nmod	_	_
23	did	do	VBD	VBD	_	25	aux	_	_
24	not	not	RB	RB	_	25	neg	_	_
25	decrease	decrease	VB	VB	_	12	advcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	number	number	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	IL-4	il-4	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	27	nmod	_	_
32	per	per	IN	IN	_	33	case	_	_
33	cell	cell	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	suppression	suppression	NN	NN	_	13	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	IL-1R	il-1r	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	3	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-10	il-10	NN	NN	_	9	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	17	case	_	_
15	decreased	decrease	VBN	VBN	_	17	amod	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	17	conj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	IL-4/IL-13-inducible	il-4/il-13-inducible	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	Stat6	stat6	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	13	punct	_	_
29	suggesting	suggest	VBG	VBG	_	13	advcl	_	_
30	a	a	DT	DT	_	32	det	_	_
31	potential	potential	JJ	JJ	_	32	amod	_	_
32	mechanism	mechanism	NN	NN	_	29	dobj	_	_
33	by	by	IN	IN	_	34	case	_	_
34	which	which	WDT	WDT	_	39	nmod	_	_
35	IFN-gamma	ifn-gamma	NN	NN	_	39	nsubj	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	IL-10	il-10	NN	NN	_	35	conj	_	_
38	may	may	MD	MD	_	39	aux	_	_
39	mediate	mediate	VB	VB	_	32	acl:relcl	_	_
40	their	they	PRP$	PRP$	_	42	nmod:poss	_	_
41	suppressive	suppressive	JJ	JJ	_	42	amod	_	_
42	effects	effect	NNS	NNS	_	39	dobj	_	_
43	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	certain	certain	JJ	JJ	_	6	amod	_	_
6	cytokines	cytokine	NNS	NNS	_	13	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	including	include	VBG	VBG	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-10	il-10	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	antagonize	antagonize	VBP	VBP	_	3	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	ability	ability	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IL-4	il-4	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-13	il-13	NN	NN	_	17	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	induce	induce	VB	VB	_	15	acl	_	_
22	increased	increase	VBN	VBN	_	23	amod	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	dep	_	_
26	IL-1RI	il-1ri	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	IL-1RII	il-1rii	NN	NN	_	29	compound	_	_
29	genes	gene	NNS	NNS	_	26	conj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Stat-3	stat-3	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	involved	involve	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	induction	induction	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
11	after	after	IN	IN	_	12	case	_	_
12	ligation	ligation	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	19	case	_	_
14	major	major	JJ	JJ	_	19	amod	_	_
15	histocompatibility	histocompatibility	NN	NN	_	19	compound	_	_
16	complex	complex	NN	NN	_	19	compound	_	_
17	class	class	NN	NN	_	19	compound	_	_
18	I	i	NN	NN	_	19	compound	_	_
19	molecules	molecule	NNS	NNS	_	12	nmod	_	_
20	on	on	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	Jurkat	jurkat	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	31	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Janus	janus	NN	NN	_	5	compound	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	kinases	kinase	NNS	NNS	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	Jak	jak	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	Signal	signal	NN	NN	_	11	compound	_	_
11	transducers	transducer	NNS	NNS	_	5	conj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	activators	activator	NNS	NNS	_	15	compound	_	_
14	of	of	IN	IN	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	11	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Stat	stat	NNS	NNS	_	11	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	after	after	IN	IN	_	20	case	_	_
20	ligation	ligation	NN	NN	_	1	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	major	major	JJ	JJ	_	25	amod	_	_
23	histocompatibility	histocompatibility	NN	NN	_	25	compound	_	_
24	complex	complex	NN	NN	_	25	compound	_	_
25	class	class	NN	NN	_	20	nmod	_	_
26	I	i	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	MHC-I	mhc-i	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	explored	explore	VBN	VBN	_	0	root	_	_
32	in	in	IN	IN	_	35	case	_	_
33	Jurkat	jurkat	NN	NN	_	35	compound	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	31	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	MHC-I	mhc-i	NN	NN	_	1	nmod	_	_
4	mediated	mediate	VBD	VBD	_	0	root	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Tyk2	tyk2	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	8	cc	_	_
12	Jak1	jak1	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	12	punct	_	_
14	Jak2	Jak2	NNP	NNP	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	Jak3	jak3	NN	NN	_	12	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	10	nsubjpass	_	_
7	Stat-3	stat-3	NN	NN	_	6	dep	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	tyrosine	tyrosine	NN	NN	_	10	dep	_	_
10	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	subsequently	subsequently	RB	RB	_	16	advmod	_	_
16	translocated	translocate	VBN	VBN	_	10	conj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	nucleus	nucleus	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Data	data	NN	NN	_	8	nsubj	_	_
2	obtained	obtain	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	7	case	_	_
4	electrophoretic	electrophoretic	JJ	JJ	_	7	amod	_	_
5	mobility	mobility	NN	NN	_	7	compound	_	_
6	shift	shift	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	2	nmod	_	_
8	suggested	suggest	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	13	det	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	Stat-3	stat-3	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	14	nsubj	_	_
14	associates	associate	VBZ	VBZ	_	8	ccomp	_	_
15	with	with	IN	IN	_	23	case	_	_
16	the	the	DT	DT	_	23	det	_	_
17	human	human	JJ	JJ	_	23	amod	_	_
18	serum-inducible	serum-inducible	JJ	JJ	_	23	amod	_	_
19	element	element	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	hSIE	hsie	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	DNA-probe	dna-probe	NN	NN	_	14	nmod	_	_
24	derived	derive	VBN	VBN	_	23	acl	_	_
25	from	from	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	interferon-gamma	interferon-gamma	NN	NN	_	29	compound	_	_
28	activated	activated	JJ	JJ	_	29	amod	_	_
29	site	site	NN	NN	_	24	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	GAS	gas	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	c-fos	c-fos	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	29	nmod	_	_
37	,	,	,	,	_	29	punct	_	_
38	a	a	DT	DT	_	41	det	_	_
39	common	common	JJ	JJ	_	41	amod	_	_
40	DNA	dna	NN	NN	_	41	compound	_	_
41	sequence	sequence	NN	NN	_	29	appos	_	_
42	for	for	IN	IN	_	45	case	_	_
43	Stat	stat	NNS	NNS	_	44	compound	_	_
44	protein	protein	NN	NN	_	45	compound	_	_
45	binding	binding	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	8	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	association	association	NN	NN	_	12	nsubjpass	_	_
3	between	between	IN	IN	_	4	case	_	_
4	hSIE	hsie	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Stat-3	stat-3	NN	NN	_	4	conj	_	_
7	after	after	IN	IN	_	9	case	_	_
8	MHC-I	mhc-i	NN	NN	_	9	compound	_	_
9	ligation	ligation	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	directly	directly	RB	RB	_	12	advmod	_	_
12	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	precipitating	precipitate	VBG	VBG	_	12	advcl	_	_
15	Stat-3	stat-3	NN	NN	_	14	dobj	_	_
16	from	from	IN	IN	_	18	case	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	14	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	biotinylated	biotinylate	VBN	VBN	_	22	amod	_	_
21	hSIE	hsie	NN	NN	_	22	compound	_	_
22	probe	probe	NN	NN	_	14	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	avidin-coupled	avidin-coupled	JJ	JJ	_	25	amod	_	_
25	agarose	agarose	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	function	function	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	activated	activate	VBN	VBN	_	8	amod	_	_
8	Stat-3	stat-3	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	Jurkat	jurkat	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	15	nsubjpass	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	transiently	transiently	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBN	VBN	_	2	parataxis	_	_
16	with	with	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	Stat-3	stat-3	NN	NN	_	19	compound	_	_
19	isoform	isoform	NN	NN	_	15	nmod	_	_
20	lacking	lack	VBG	VBG	_	19	acl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transactivating	transactivate	VBG	VBG	_	23	amod	_	_
23	domain	domain	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	5	det	_	_
2	dominant-negative	dominant-negative	JJ	JJ	_	5	amod	_	_
3	acting	act	VBG	VBG	_	5	amod	_	_
4	Stat-3	stat-3	NN	NN	_	5	compound	_	_
5	isoform	isoform	NN	NN	_	7	nsubj	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ligation	ligation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	MHC-I	mhc-i	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	involvement	involvement	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	Jak/Stat	jak/stat	NN	NN	_	13	compound	_	_
12	signal	signal	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	MHC-I-induced	mhc-i-induced	JJ	JJ	_	17	amod	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	8	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	MLL	mll	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CALM	calm	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	fused	fuse	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	AF10	af10	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	morphologically	morphologically	RB	RB	_	10	advmod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	subsets	subset	NNS	NNS	_	5	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	acute	acute	JJ	JJ	_	14	amod	_	_
14	leukemia	leukemia	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	translocation	translocation	NN	NN	_	17	compound	_	_
17	t(10;11)	t(10;11)	NN	NN	_	11	nmod	_	_
18	:	:	:	:	_	5	punct	_	_
19	both	both	DT	DT	_	20	det	_	_
20	rearrangements	rearrangement	NNS	NNS	_	22	nsubjpass	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	5	parataxis	_	_
23	with	with	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	poor	poor	JJ	JJ	_	26	amod	_	_
26	prognosis	prognosis	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	translocation	translocation	NN	NN	_	3	compound	_	_
3	t(10;11)(p13;q14)	t(10;11)(p13;q14)	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	acute	acute	JJ	JJ	_	10	amod	_	_
9	lymphoblastic	lymphoblastic	JJ	JJ	_	10	amod	_	_
10	leukemia	leukemia	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	ALL	all	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	as	as	RB	RB	_	10	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	acute	acute	JJ	JJ	_	19	amod	_	_
18	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
19	leukemia	leukemia	NN	NN	_	10	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	AML	aml	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	recent	recent	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	MLL/AF10	mll/af10	NN	NN	_	7	compound	_	_
7	fusion	fusion	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	all	all	DT	DT	_	10	det	_	_
10	cases	case	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	AML	aml	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	t(10;11)	t(10;11)	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	various	various	JJ	JJ	_	17	amod	_	_
17	breakpoints	breakpoint	NNS	NNS	_	14	conj	_	_
18	on	on	IN	IN	_	19	case	_	_
19	chromosome	chromosome	NN	NN	_	17	nmod	_	_
20	11	11	CD	CD	_	19	nummod	_	_
21	ranging	range	VBG	VBG	_	17	acl	_	_
22	from	from	IN	IN	_	23	case	_	_
23	q13	q13	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	q23	q23	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	cloned	clone	VBN	VBN	_	0	root	_	_
4	CALM	calm	NN	NN	_	3	dobj	_	_
5	(	(	-LRB-	-LRB-	_	11	punct	_	_
6	Clathrin	clathrin	NN	NN	_	11	compound	_	_
7	Assembly	assembly	NN	NN	_	11	compound	_	_
8	Lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
9	Myeloid	myeloid	JJ	JJ	_	11	amod	_	_
10	leukemia	leukemia	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	4	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	4	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	fusion	fusion	NN	NN	_	16	compound	_	_
16	partner	partner	NN	NN	_	4	appos	_	_
17	of	of	IN	IN	_	18	case	_	_
18	AF10	af10	NN	NN	_	16	nmod	_	_
19	at	at	IN	IN	_	20	case	_	_
20	11q14	11q14	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	monocytic	monocytic	JJ	JJ	_	26	amod	_	_
24	cell	cell	NN	NN	_	26	compound	_	_
25	line	line	NN	NN	_	26	compound	_	_
26	U937	u937	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	define	define	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	acute	acute	JJ	JJ	_	11	amod	_	_
11	leukemias	leukemia	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	3	punct	_	_
13	10	10	CD	CD	_	14	nummod	_	_
14	cases	case	NNS	NNS	_	36	nsubjpass	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	9	9	CD	CD	_	17	nummod	_	_
17	AML	aml	NN	NN	_	14	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	ALL	all	NN	NN	_	17	conj	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	with	with	IN	IN	_	25	case	_	_
23	cytogenetically	cytogenetically	RB	RB	_	24	advmod	_	_
24	proven	proven	JJ	JJ	_	25	amod	_	_
25	t(10;11)(p12-14;q13-21)	t(10;11)(p12-14;q13-21)	NN	NN	_	14	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	well-characterized	well-characterize	VBD	VBD	_	28	amod	_	_
28	morphology	morphology	NN	NN	_	25	conj	_	_
29	,	,	,	,	_	28	punct	_	_
30	immunophenotype	immunophenotype	NN	NN	_	28	conj	_	_
31	,	,	,	,	_	28	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	clinical	clinical	JJ	JJ	_	34	amod	_	_
34	course	course	NN	NN	_	28	conj	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	analyzed	analyze	VBN	VBN	_	3	parataxis	_	_
37	.	.	.	.	_	3	punct	_	_

1	Interphase	interphase	NN	NN	_	10	nsubjpass	_	_
2	fluorescence	fluorescence	NN	NN	_	5	compound	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	situ	situ	FW	FW	_	3	dep	_	_
5	hybridization	hybridization	NN	NN	_	1	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	FISH	fish	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	performed	perform	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	2	2	CD	CD	_	13	nummod	_	_
13	YACs	yac	NNS	NNS	_	10	nmod	_	_
14	flanking	flank	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CALM	calm	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	13	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	YAC	yac	NN	NN	_	21	compound	_	_
21	contig	contig	NN	NN	_	13	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	MLL	mll	NN	NN	_	25	compound	_	_
25	region	region	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	13	punct	_	_
27	and	and	CC	CC	_	13	cc	_	_
28	a	a	DT	DT	_	29	det	_	_
29	YAC	yac	NN	NN	_	13	conj	_	_
30	spanning	span	VBG	VBG	_	29	acl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	AF10	af10	NN	NN	_	33	compound	_	_
33	breakpoint	breakpoint	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	10	punct	_	_

1	Rearrangement	rearrangement	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	at	at	IN	IN	_	4	case	_	_
4	least	least	JJS	JJS	_	5	nmod:npmod	_	_
5	one	one	CD	CD	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	all	all	DT	DT	_	13	det	_	_
13	cases	case	NNS	NNS	_	10	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	balanced	balanced	JJ	JJ	_	16	amod	_	_
16	t(10;11)	t(10;11)	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	4	4	CD	CD	_	3	nummod	_	_
3	cases	case	NNS	NNS	_	29	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	including	include	VBG	VBG	_	7	case	_	_
6	3	3	CD	CD	_	7	nummod	_	_
7	AML	aml	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	immature	immature	JJ	JJ	_	10	amod	_	_
10	morphology	morphology	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	AML-M0	aml-m0	NN	NN	_	7	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	2	2	CD	CD	_	16	nummod	_	_
16	AML-M1	aml-m1	NN	NN	_	13	conj	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	ALL	all	NN	NN	_	7	conj	_	_
21	,	,	,	,	_	29	punct	_	_
22	the	the	DT	DT	_	23	det	_	_
23	signals	signal	NNS	NNS	_	29	nsubjpass	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	CALM	calm	NN	NN	_	27	compound	_	_
27	YACS	yac	NNS	NNS	_	23	nmod	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	separated	separate	VBN	VBN	_	0	root	_	_
30	in	in	IN	IN	_	32	case	_	_
31	interphase	interphase	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	29	punct	_	_
34	indicating	indicate	VBG	VBG	_	29	advcl	_	_
35	a	a	DT	DT	_	37	det	_	_
36	translocation	translocation	NN	NN	_	37	compound	_	_
37	breakpoint	breakpoint	NN	NN	_	34	dobj	_	_
38	within	within	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	CALM	calm	NN	NN	_	41	compound	_	_
41	region	region	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	29	punct	_	_

1	MLL	mll	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	rearranged	rearrange	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	3	3	CD	CD	_	6	nummod	_	_
6	AML	aml	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	myelomonocytic	myelomonocytic	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	2	2	CD	CD	_	12	nummod	_	_
12	AML-M2	aml-m2	NN	NN	_	6	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	AML-M5	aml-m5	NN	NN	_	12	conj	_	_
16	)	)	-RRB-	-RRB-	_	12	punct	_	_
17	,	,	,	,	_	3	punct	_	_
18	including	include	VBG	VBG	_	21	case	_	_
19	1	1	CD	CD	_	21	nummod	_	_
20	secondary	secondary	JJ	JJ	_	21	amod	_	_
21	AML	aml	NN	NN	_	3	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	all	all	DT	DT	_	4	det	_	_
3	3	3	CD	CD	_	4	nummod	_	_
4	cases	case	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	characteristic	characteristic	JJ	JJ	_	8	amod	_	_
8	immunophenotype	immunophenotype	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CD4+	cd4+	JJ	JJ	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	CD13-	cd13-	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	CD33+	cd33+	JJ	JJ	_	12	appos	_	_
17	,	,	,	,	_	12	punct	_	_
18	CD65s+	cd65s+	JJ	JJ	_	12	appos	_	_
19	)	)	-RRB-	-RRB-	_	12	punct	_	_
20	.	.	.	.	_	10	punct	_	_

1	AF-10	af-10	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	involved	involve	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	9	case	_	_
5	5	5	CD	CD	_	7	compound	_	_
6	of	of	IN	IN	_	7	advmod	_	_
7	6	6	CD	CD	_	9	nummod	_	_
8	evaluable	evaluable	JJ	JJ	_	9	amod	_	_
9	cases	case	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	13	case	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	case	case	NN	NN	_	9	nmod	_	_
14	without	without	IN	IN	_	16	case	_	_
15	detectable	detectable	JJ	JJ	_	16	amod	_	_
16	CALM	calm	NN	NN	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	MLL	mll	NN	NN	_	19	compound	_	_
19	rearrangement	rearrangement	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	2	2	CD	CD	_	4	nummod	_	_
3	complex	complex	NN	NN	_	4	compound	_	_
4	translocations	translocation	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	none	none	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	three	three	CD	CD	_	10	nummod	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	rearranged	rearrange	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	cases	case	NNS	NNS	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	remarkably	remarkably	RB	RB	_	6	advmod	_	_
6	poor	poor	JJ	JJ	_	7	amod	_	_
7	prognosis	prognosis	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	3	punct	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	mean	mean	NN	NN	_	12	compound	_	_
12	survival	survival	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	9.6	9.6	CD	CD	_	17	nummod	_	_
15	+/-	+/-	CC	CC	_	14	cc	_	_
16	6.6	6.6	CD	CD	_	14	conj	_	_
17	months	month	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	For	for	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	7	7	CD	CD	_	5	nummod	_	_
4	AML	aml	NN	NN	_	5	compound	_	_
5	cases	case	NNS	NNS	_	22	nmod	_	_
6	that	that	WDT	WDT	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	uniformly	uniformly	RB	RB	_	9	advmod	_	_
9	treated	treat	VBN	VBN	_	5	acl:relcl	_	_
10	according	accord	VBG	VBG	_	14	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	the	the	DT	DT	_	14	det	_	_
13	AMLCG86/92	amlcg86/92	NN	NN	_	14	compound	_	_
14	protocols	protocol	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	22	punct	_	_
16	disease-free	disease-free	JJ	JJ	_	22	nsubj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	overall	overall	JJ	JJ	_	16	conj	_	_
19	survival	survival	NN	NN	_	16	dep	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	worse	worse	JJ	JJ	_	0	root	_	_
23	than	than	IN	IN	_	28	case	_	_
24	for	for	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	overall	overall	JJ	JJ	_	28	amod	_	_
27	study	study	NN	NN	_	28	compound	_	_
28	group	group	NN	NN	_	22	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	P	p	NN	NN	_	22	dep	_	_
31	=	=	JJ	JJ	_	30	amod	_	_
32	.03	.03	CD	CD	_	31	dep	_	_
33	and	and	CC	CC	_	30	cc	_	_
34	P	p	NN	NN	_	30	conj	_	_
35	=	=	JJ	JJ	_	34	amod	_	_
36	.01	.01	CD	CD	_	35	dep	_	_
37	,	,	,	,	_	30	punct	_	_
38	respectively	respectively	RB	RB	_	30	advmod	_	_
39	)	)	-RRB-	-RRB-	_	30	punct	_	_
40	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	t(10;11)(p13;q14)	t(10;11)(p13;q14)	NN	NN	_	6	nsubj	_	_
6	indicates	indicate	VBZ	VBZ	_	2	ccomp	_	_
7	CALM	calm	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	MLL	mll	NN	NN	_	7	conj	_	_
10	rearrangements	rearrangement	NNS	NNS	_	7	dep	_	_
11	in	in	IN	IN	_	14	case	_	_
12	morphologically	morphologically	RB	RB	_	13	advmod	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	subsets	subset	NNS	NNS	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	acute	acute	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	associated	associate	VBN	VBN	_	6	conj	_	_
22	with	with	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	poor	poor	JJ	JJ	_	25	amod	_	_
25	prognosis	prognosis	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	IL-2-induced	il-2-induced	JJ	JJ	_	2	amod	_	_
2	growth	growth	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	CD8+	cd8+	JJ	JJ	_	9	amod	_	_
5	T	t	NN	NN	_	9	compound	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	prolymphocytic	prolymphocytic	JJ	JJ	_	9	amod	_	_
8	leukemia	leukemia	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	mediated	mediate	VBN	VBN	_	2	acl	_	_
11	by	by	IN	IN	_	13	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IL-2	il-2	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin-2	interleukin-2	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IL-2	il-2	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	to	to	TO	TO	_	10	case	_	_
9	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
10	receptor	receptor	NN	NN	_	2	nmod	_	_
11	on	on	IN	IN	_	14	case	_	_
12	normal	normal	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	induces	induce	VBZ	VBZ	_	0	root	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	kappaB	kappab	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	17	punct	_	_
26	activation	activation	NN	NN	_	17	conj	_	_
27	of	of	IN	IN	_	36	case	_	_
28	the	the	DT	DT	_	36	det	_	_
29	IL-2	il-2	NN	NN	_	36	compound	_	_
30	receptor	receptor	NN	NN	_	36	compound	_	_
31	(	(	-LRB-	-LRB-	_	36	punct	_	_
32	IL-2R	il-2r	NN	NN	_	36	compound	_	_
33	)	)	-RRB-	-RRB-	_	36	punct	_	_
34	alpha	alpha	NN	NN	_	36	compound	_	_
35	chain	chain	NN	NN	_	36	compound	_	_
36	gene	gene	NN	NN	_	26	nmod	_	_
37	,	,	,	,	_	17	punct	_	_
38	and	and	CC	CC	_	17	cc	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	proliferation	proliferation	NN	NN	_	17	conj	_	_
41	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	26	nmod	_	_
5	,	,	,	,	_	26	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	26	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IL-2R	il-2r	NN	NN	_	10	compound	_	_
10	signaling	signaling	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	growth	growth	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	23	case	_	_
15	CD8+	cd8+	JJ	JJ	_	23	amod	_	_
16	T	t	NN	NN	_	23	compound	_	_
17	cell	cell	NN	NN	_	23	compound	_	_
18	prolymphocytic	prolymphocytic	JJ	JJ	_	23	amod	_	_
19	leukemia	leukemia	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	T-PLL	t-pll	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	cells	cell	NNS	NNS	_	13	nmod	_	_
24	has	have	VBZ	VBZ	_	26	aux	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	investigated	investigate	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Flow	flow	NN	NN	_	2	compound	_	_
2	cytometry	cytometry	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	primary	primary	JJ	JJ	_	7	amod	_	_
6	leukemia	leukemia	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	14	nsubj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	patient	patient	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	CD8+	cd8+	JJ	JJ	_	13	amod	_	_
13	T-PLL	t-pll	NN	NN	_	10	nmod	_	_
14	expressed	express	VBD	VBD	_	3	ccomp	_	_
15	IL-2Ralpha	il-2ralpha	NN	NN	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	beta	beta	NN	NN	_	15	conj	_	_
18	chains	chain	NNS	NNS	_	15	dep	_	_
19	,	,	,	,	_	3	punct	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cells	cell	NNS	NNS	_	23	nsubj	_	_
23	showed	show	VBD	VBD	_	3	conj	_	_
24	a	a	DT	DT	_	26	det	_	_
25	proliferative	proliferative	JJ	JJ	_	26	amod	_	_
26	response	response	NN	NN	_	23	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	an	a	DT	DT	_	29	det	_	_
29	increase	increase	NN	NN	_	26	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	IL-2Ralpha	il-2ralpha	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	26	nmod	_	_
33	on	on	IN	IN	_	34	case	_	_
34	culture	culture	NN	NN	_	23	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	exogeneous	exogeneous	JJ	JJ	_	37	amod	_	_
37	IL-2	il-2	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	failed	fail	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	detect	detect	VB	VB	_	4	xcomp	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	suggesting	suggest	VBG	VBG	_	4	xcomp	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	IL-2	il-2	NN	NN	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	act	act	VB	VB	_	10	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	paracrine	paracrine	JJ	JJ	_	18	amod	_	_
18	manner	manner	NN	NN	_	14	nmod	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vivo	vivo	FW	FW	_	14	advmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	3	amod	_	_
2	mobility-shift	mobility-shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
7	IL-2	il-2	NN	NN	_	8	nsubj	_	_
8	increased	increase	VBD	VBD	_	4	ccomp	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	leukemia	leukemia	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	Northern	northern	NN	NN	_	23	compound	_	_
22	blot	blot	NN	NN	_	23	compound	_	_
23	analysis	analysis	NN	NN	_	24	nsubj	_	_
24	showed	show	VBD	VBD	_	4	conj	_	_
25	that	that	IN	IN	_	27	mark	_	_
26	IL-2	il-2	NN	NN	_	27	nsubj	_	_
27	increased	increase	VBD	VBD	_	24	ccomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	abundance	abundance	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	mRNAs	mrna	NNS	NNS	_	29	nmod	_	_
32	encoding	encode	VBG	VBG	_	31	acl	_	_
33	the	the	DT	DT	_	35	det	_	_
34	NF-kappaB	nf-kappab	NN	NN	_	35	compound	_	_
35	components	component	NNS	NNS	_	32	dobj	_	_
36	c-Rel	c-rel	NN	NN	_	35	dep	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	KBF1	kbf1	NN	NN	_	36	conj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	these	these	DT	DT	_	41	det	_	_
41	cells	cell	NNS	NNS	_	29	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	IL-2	il-2	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	IL-2	il-2	NN	NN	_	8	nsubj	_	_
7	markedly	markedly	RB	RB	_	8	advmod	_	_
8	increased	increase	VBD	VBD	_	4	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	low	low	JJ	JJ	_	13	amod	_	_
13	affinity	affinity	NN	NN	_	10	nmod	_	_
14	IL-2Rs	il-2r	NNS	NNS	_	13	dep	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	leukemia	leukemia	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	without	without	IN	IN	_	22	case	_	_
21	an	a	DT	DT	_	22	det	_	_
22	effect	effect	NN	NN	_	8	nmod	_	_
23	on	on	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	number	number	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	high-affinity	high-affinity	JJ	JJ	_	28	amod	_	_
28	IL-2Rs	il-2r	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IL-2	il-2	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	capable	capable	JJ	JJ	_	3	ccomp	_	_
8	of	of	IN	IN	_	9	mark	_	_
9	inducing	induce	VBG	VBG	_	7	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	primary	primary	JJ	JJ	_	19	amod	_	_
17	CD8+	cd8+	JJ	JJ	_	19	amod	_	_
18	T-PLL	t-pll	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	9	nmod	_	_
20	,	,	,	,	_	7	punct	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	that	that	IN	IN	_	26	mark	_	_
23	this	this	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	mediated	mediate	VBN	VBN	_	7	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	at	at	IN	IN	_	31	advmod	_	_
29	least	least	JJS	JJS	_	28	mwe	_	_
30	in	in	IN	IN	_	31	case	_	_
31	part	part	NN	NN	_	26	nmod	_	_
32	,	,	,	,	_	26	punct	_	_
33	at	at	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	pretranslational	pretranslational	JJ	JJ	_	36	amod	_	_
36	level	level	NN	NN	_	26	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	toll	toll	NN	NN	_	5	compound	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	0	root	_	_
6	:	:	:	:	_	5	punct	_	_
7	divergence	divergence	NN	NN	_	5	dep	_	_
8	of	of	IN	IN	_	11	case	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	kappaB	kappab	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	JNK/SAPK	jnk/sapk	NN	NN	_	11	conj	_	_
14	activation	activation	NN	NN	_	11	dep	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	tumor	tumor	NN	NN	_	21	compound	_	_
18	necrosis	necrosis	NN	NN	_	21	compound	_	_
19	factor	factor	NN	NN	_	21	compound	_	_
20	receptor-associated	receptor-associated	JJ	JJ	_	21	amod	_	_
21	factor	factor	NN	NN	_	15	nmod	_	_
22	6	6	CD	CD	_	21	nummod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TRAF6	traf6	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	homologue	homologue	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Drosophila	drosophila	FW	FW	_	6	compound	_	_
6	Toll	toll	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	hToll	htoll	NN	NN	_	3	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	recently	recently	RB	RB	_	13	advmod	_	_
13	cloned	clone	VBN	VBN	_	14	amod	_	_
14	receptor	receptor	NN	NN	_	0	root	_	_
15	of	of	IN	IN	_	23	case	_	_
16	the	the	DT	DT	_	23	det	_	_
17	interleukin	interleukin	NN	NN	_	23	compound	_	_
18	1	1	CD	CD	_	23	nummod	_	_
19	receptor	receptor	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	IL-1R	il-1r	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	superfamily	superfamily	NN	NN	_	14	nmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	has	have	VBZ	VBZ	_	28	aux	_	_
27	been	be	VBN	VBN	_	28	auxpass	_	_
28	implicated	implicate	VBN	VBN	_	14	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	activation	activation	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	adaptive	adaptive	JJ	JJ	_	34	amod	_	_
34	immunity	immunity	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	14	punct	_	_

1	Signaling	signaling	NN	NN	_	5	nsubjpass	_	_
2	by	by	IN	IN	_	3	case	_	_
3	hToll	htoll	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	occur	occur	VB	VB	_	5	xcomp	_	_
8	through	through	IN	IN	_	10	case	_	_
9	sequential	sequential	JJ	JJ	_	10	amod	_	_
10	recruitment	recruitment	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	adapter	adapter	NN	NN	_	14	compound	_	_
14	molecule	molecule	NN	NN	_	10	nmod	_	_
15	MyD88	myd88	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-1R-associated	il-1r-associated	JJ	JJ	_	19	amod	_	_
19	kinase	kinase	NN	NN	_	14	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Tumor	tumor	NN	NN	_	5	compound	_	_
2	necrosis	necrosis	NN	NN	_	5	compound	_	_
3	factor	factor	NN	NN	_	5	compound	_	_
4	receptor-activated	receptor-activated	JJ	JJ	_	5	amod	_	_
5	factor	factor	NN	NN	_	23	nsubjpass	_	_
6	6	6	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TRAF6	traf6	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	the	the	DT	DT	_	19	det	_	_
12	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
13	factor	factor	NN	NN	_	19	compound	_	_
14	kappaB	kappab	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	-inducing	-inducing	JJ	JJ	_	19	amod	_	_
19	kinase	kinase	NN	NN	_	5	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	NIK	nik	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	are	be	VBP	VBP	_	0	root	_	_
24	both	both	CC	CC	_	23	dep	_	_
25	involved	involve	VBN	VBN	_	23	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	subsequent	subsequent	JJ	JJ	_	28	amod	_	_
28	steps	step	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	23	punct	_	_

1	Conversely	conversely	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	dominant	dominant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	version	version	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TRAF6	traf6	NN	NN	_	6	nmod	_	_
9	failed	fail	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	block	block	VB	VB	_	9	xcomp	_	_
12	hToll-induced	htoll-induced	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	stress-activated	stress-activated	JJ	JJ	_	19	amod	_	_
16	protein	protein	NN	NN	_	19	compound	_	_
17	kinase/c-Jun	kinase/c-jun	NN	NN	_	19	compound	_	_
18	NH2-terminal	nh2-terminal	JJ	JJ	_	19	amod	_	_
19	kinases	kinase	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	thus	thus	RB	RB	_	22	advmod	_	_
22	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
23	an	a	DT	DT	_	25	det	_	_
24	early	early	JJ	JJ	_	25	amod	_	_
25	divergence	divergence	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	two	two	CD	CD	_	29	nummod	_	_
29	pathways	pathway	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	Coactivation	coactivation	NN	NN	_	0	root	_	_
2	by	by	IN	IN	_	3	case	_	_
3	OCA-B	oca-b	NN	NN	_	1	nmod	_	_
4	:	:	:	:	_	1	punct	_	_
5	definition	definition	NN	NN	_	1	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	critical	critical	JJ	JJ	_	8	amod	_	_
8	regions	region	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	synergism	synergism	NN	NN	_	5	conj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	general	general	JJ	JJ	_	13	amod	_	_
13	cofactors	cofactor	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	dissection	dissection	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	B-cell-specific	b-cell-specific	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	coactivator	coactivator	NN	NN	_	2	nmod	_	_
8	OCA-B	oca-b	NN	NN	_	7	dep	_	_
9	has	have	VBZ	VBZ	_	10	aux	_	_
10	revealed	reveal	VBN	VBN	_	0	root	_	_
11	distinct	distinct	JJ	JJ	_	12	amod	_	_
12	regions	region	NNS	NNS	_	10	dobj	_	_
13	important	important	JJ	JJ	_	12	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	respectively	respectively	RB	RB	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	for	for	IN	IN	_	18	case	_	_
18	recruitment	recruitment	NN	NN	_	15	conj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	immunoglobulin	immunoglobulin	NN	NN	_	21	compound	_	_
21	promoters	promoter	NNS	NNS	_	18	nmod	_	_
22	through	through	IN	IN	_	23	case	_	_
23	interaction	interaction	NN	NN	_	18	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	octamer-bound	octamer-bound	JJ	JJ	_	26	amod	_	_
26	Oct-1	oct-1	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	15	cc	_	_
28	for	for	IN	IN	_	31	case	_	_
29	subsequent	subsequent	JJ	JJ	_	31	amod	_	_
30	coactivator	coactivator	NN	NN	_	31	compound	_	_
31	function	function	NN	NN	_	15	conj	_	_
32	.	.	.	.	_	10	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	general	general	JJ	JJ	_	6	amod	_	_
5	coactivator	coactivator	NN	NN	_	6	compound	_	_
6	requirements	requirement	NNS	NNS	_	2	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	selective	selective	JJ	JJ	_	10	amod	_	_
10	removal	removal	NN	NN	_	19	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	PC4	pc4	NN	NN	_	10	nmod	_	_
13	from	from	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	essential	essential	JJ	JJ	_	17	amod	_	_
16	USA	usa	NN	NN	_	17	compound	_	_
17	fraction	fraction	NN	NN	_	10	nmod	_	_
18	severely	severely	RB	RB	_	19	advmod	_	_
19	impairs	impair	VBZ	VBZ	_	7	ccomp	_	_
20	Oct-1	oct-1	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	OCA-B	oca-b	NN	NN	_	20	conj	_	_
23	function	function	NN	NN	_	20	dep	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	cell-free	cell-free	JJ	JJ	_	27	amod	_	_
27	system	system	NN	NN	_	20	nmod	_	_
28	reconstituted	reconstitute	VBN	VBN	_	27	acl	_	_
29	with	with	IN	IN	_	32	case	_	_
30	partially	partially	RB	RB	_	31	advmod	_	_
31	purified	purify	VBN	VBN	_	32	amod	_	_
32	factors	factor	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	Full	full	JJ	JJ	_	2	amod	_	_
2	activity	activity	NN	NN	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	restored	restore	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	combined	combined	JJ	JJ	_	9	amod	_	_
9	action	action	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	recombinant	recombinant	JJ	JJ	_	12	amod	_	_
12	PC4	pc4	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	17	det	_	_
15	PC4-depleted	pc4-depleted	JJ	JJ	_	17	amod	_	_
16	USA	usa	NN	NN	_	17	compound	_	_
17	fraction	fraction	NN	NN	_	12	conj	_	_
18	,	,	,	,	_	5	punct	_	_
19	thus	thus	RB	RB	_	20	advmod	_	_
20	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
21	a	a	DT	DT	_	23	det	_	_
22	joint	joint	NN	NN	_	23	compound	_	_
23	requirement	requirement	NN	NN	_	20	dobj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	PC4	pc4	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	another	another	DT	DT	_	32	amod	_	_
28	,	,	,	,	_	27	punct	_	_
29	USA-derived	usa-derived	JJ	JJ	_	27	dep	_	_
30	component	component	NN	NN	_	32	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	s	s	NNS	NNS	_	25	conj	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	for	for	IN	IN	_	36	case	_	_
35	optimal	optimal	JJ	JJ	_	36	amod	_	_
36	function	function	NN	NN	_	23	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	Oct-1/OCA-B	oct-1/oca-b	NN	NN	_	36	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	reconstituted	reconstituted	JJ	JJ	_	42	amod	_	_
42	system	system	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	5	punct	_	_

1	Indeed	indeed	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	USA-derived	usa-derived	JJ	JJ	_	4	amod	_	_
4	PC2	pc2	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	act	act	VB	VB	_	6	xcomp	_	_
9	synergistically	synergistically	RB	RB	_	8	advmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	PC4	pc4	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	reproducing	reproduce	VBG	VBG	_	8	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	function	function	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	intact	intact	JJ	JJ	_	18	amod	_	_
18	USA	usa	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	assay	assay	NN	NN	_	22	compound	_	_
22	system	system	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Consistent	consistent	JJ	JJ	_	14	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	requirement	requirement	NN	NN	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	PC4	pc4	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	reconstituted	reconstituted	JJ	JJ	_	10	amod	_	_
10	system	system	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	OCA-B	oca-b	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	interact	interact	VB	VB	_	14	xcomp	_	_
17	directly	directly	RB	RB	_	16	advmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	PC4	pc4	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	however	however	RB	RB	_	13	advmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	removal	removal	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PC4	pc4	NN	NN	_	5	nmod	_	_
8	from	from	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	unfractionated	unfractionated	JJ	JJ	_	12	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	extract	extract	NN	NN	_	5	nmod	_	_
13	has	have	VBZ	VBZ	_	0	root	_	_
14	no	no	DT	DT	_	16	neg	_	_
15	detrimental	detrimental	JJ	JJ	_	16	amod	_	_
16	effect	effect	NN	NN	_	13	dobj	_	_
17	on	on	IN	IN	_	19	case	_	_
18	OCA-B/Oct-1-dependent	oca-b/oct-1-dependent	JJ	JJ	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	lead	lead	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	general	general	JJ	JJ	_	7	amod	_	_
7	model	model	NN	NN	_	3	nmod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	synergistic	synergistic	JJ	JJ	_	11	amod	_	_
11	function	function	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	activation	activation	NN	NN	_	14	compound	_	_
14	domains	domain	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	Oct-1	oct-1	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	OCA-B	oca-b	NN	NN	_	16	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	mediated	mediate	VBN	VBN	_	11	dep	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	combined	combined	JJ	JJ	_	24	amod	_	_
24	action	action	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	multiple	multiple	JJ	JJ	_	29	amod	_	_
28	USA	usa	NN	NN	_	29	compound	_	_
29	components	component	NNS	NNS	_	24	nmod	_	_
30	)	)	-RRB-	-RRB-	_	20	punct	_	_
31	and	and	CC	CC	_	3	cc	_	_
32	,	,	,	,	_	3	punct	_	_
33	further	further	RB	RB	_	35	advmod	_	_
34	,	,	,	,	_	35	punct	_	_
35	suggest	suggest	VBP	VBP	_	3	conj	_	_
36	a	a	DT	DT	_	38	det	_	_
37	functional	functional	JJ	JJ	_	38	amod	_	_
38	redundancy	redundancy	NN	NN	_	35	dobj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	general	general	JJ	JJ	_	41	amod	_	_
41	coactivators	coactivator	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Limited	limited	JJ	JJ	_	2	amod	_	_
2	proteolysis	proteolysis	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	4	mark	_	_
4	assaying	assay	VBG	VBG	_	2	acl	_	_
5	ligand	ligand	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	affinities	affinity	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	natural	natural	JJ	JJ	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	synthetic	synthetic	JJ	JJ	_	4	conj	_	_
7	ligands	ligand	NNS	NNS	_	4	dep	_	_
8	to	to	TO	TO	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	the	the	DT	DT	_	14	det	_	_
13	triggering	trigger	VBG	VBG	_	14	amod	_	_
14	event	event	NN	NN	_	0	root	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	15	nmod	_	_
19	activation	activation	NN	NN	_	18	dep	_	_
20	or	or	CC	CC	_	18	cc	_	_
21	repression	repression	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	14	punct	_	_

1	Ligand	ligand	NN	NN	_	11	nsubj	_	_
2	binding	bind	VBG	VBG	_	1	acl	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	ligand	ligand	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	conformational	conformational	JJ	JJ	_	13	amod	_	_
13	changes	change	NNS	NNS	_	11	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	evidenced	evidence	VBN	VBN	_	13	acl:relcl	_	_
17	by	by	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	increased	increase	VBN	VBN	_	20	amod	_	_
20	resistance	resistance	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	domain	domain	NN	NN	_	20	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	proteases	protease	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	In	in	FW	FW	_	4	compound	_	_
2	vitro	vitro	FW	FW	_	4	compound	_	_
3	labeled	label	VBN	VBN	_	4	amod	_	_
4	receptors	receptor	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	incubated	incubate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	various	various	JJ	JJ	_	9	amod	_	_
9	synthetic	synthetic	JJ	JJ	_	6	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	natural	natural	JJ	JJ	_	9	conj	_	_
12	agonists	agonist	NNS	NNS	_	9	dep	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	antagonists	antagonist	NNS	NNS	_	12	conj	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	submitted	submit	VBN	VBN	_	6	conj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	trypsin	trypsin	NN	NN	_	19	compound	_	_
19	digestion	digestion	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Proteolysis	proteolysis	NN	NN	_	2	compound	_	_
2	products	product	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	separated	separate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	SDS-PAGE	sds-page	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	quantified	quantify	VBN	VBN	_	4	conj	_	_
9	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	amount	amount	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	trypsin-resistant	trypsin-resistant	JJ	JJ	_	5	amod	_	_
5	fragments	fragment	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	proportional	proportional	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	occupancy	occupancy	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ligand	ligand	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	allowed	allow	VBD	VBD	_	7	conj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	determination	determination	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	dissociation	dissociation	NN	NN	_	21	compound	_	_
21	constants	constant	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	kDa	kda	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	wild-type	wild-type	JJ	JJ	_	1	dobj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	mutated	mutate	VBN	VBN	_	3	conj	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	retinoic	retinoic	JJ	JJ	_	10	amod	_	_
8	acid	acid	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	3	dep	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	model	model	NN	NN	_	1	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	kDa	kda	NN	NN	_	16	compound	_	_
16	values	value	NNS	NNS	_	28	nsubj	_	_
17	determined	determine	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	22	case	_	_
19	classical	classical	JJ	JJ	_	22	amod	_	_
20	competition	competition	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	assays	assay	NNS	NNS	_	17	nmod	_	_
23	using	use	VBG	VBG	_	22	acl	_	_
24	tritiated	tritiated	JJ	JJ	_	25	amod	_	_
25	ligands	ligand	NNS	NNS	_	23	dobj	_	_
26	are	be	VBP	VBP	_	28	cop	_	_
27	in	in	IN	IN	_	28	case	_	_
28	agreement	agreement	NN	NN	_	1	parataxis	_	_
29	with	with	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	28	nmod	_	_
31	measured	measure	VBN	VBN	_	30	acl	_	_
32	by	by	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	proteolytic	proteolytic	JJ	JJ	_	35	amod	_	_
35	assay	assay	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	1	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	method	method	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	successfully	successfully	RB	RB	_	5	advmod	_	_
5	extended	extend	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	11	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
9	X	x	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	progesterone	progesterone	NN	NN	_	18	compound	_	_
18	receptor	receptor	NN	NN	_	11	conj	_	_
19	,	,	,	,	_	5	punct	_	_
20	thus	thus	RB	RB	_	21	advmod	_	_
21	providing	provide	VBG	VBG	_	5	advcl	_	_
22	a	a	DT	DT	_	23	det	_	_
23	basis	basis	NN	NN	_	21	dobj	_	_
24	for	for	IN	IN	_	29	case	_	_
25	a	a	DT	DT	_	29	det	_	_
26	new	new	JJ	JJ	_	29	amod	_	_
27	,	,	,	,	_	26	punct	_	_
28	faster	faster	JJR	JJR	_	26	dep	_	_
29	assay	assay	NN	NN	_	23	nmod	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	determine	determine	VB	VB	_	29	acl	_	_
32	simultaneously	simultaneously	RB	RB	_	31	advmod	_	_
33	the	the	DT	DT	_	34	dep	_	_
34	affinity	affinity	NN	NN	_	31	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	conformation	conformation	NN	NN	_	34	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	receptors	receptor	NNS	NNS	_	34	nmod	_	_
39	when	when	WRB	WRB	_	40	advmod	_	_
40	bound	bind	VBN	VBN	_	31	advcl	_	_
41	to	to	TO	TO	_	44	case	_	_
42	a	a	DT	DT	_	44	det	_	_
43	given	given	JJ	JJ	_	44	amod	_	_
44	ligand	ligand	NN	NN	_	40	nmod	_	_
45	.	.	.	.	_	5	punct	_	_

1	Mycobacterium	mycobacterium	FW	FW	_	4	compound	_	_
2	tuberculosis	tuberculosis	FW	FW	_	4	compound	_	_
3	mannose-capped	mannose-capped	JJ	JJ	_	4	amod	_	_
4	lipoarabinomannan	lipoarabinomannan	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	induce	induce	VB	VB	_	0	root	_	_
7	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	type	type	NN	NN	_	8	nmod	_	_
14	1	1	CD	CD	_	13	nummod	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	13	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	8	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Tuberculosis	tuberculosis	NN	NN	_	3	nsubj	_	_
2	has	have	VBZ	VBZ	_	3	aux	_	_
3	emerged	emerge	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	an	a	DT	DT	_	6	det	_	_
6	epidemic	epidemic	JJ	JJ	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	extended	extend	VBN	VBN	_	6	acl	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	large	large	JJ	JJ	_	12	amod	_	_
12	number	number	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	individuals	individual	NNS	NNS	_	12	nmod	_	_
15	infected	infect	VBN	VBN	_	12	acl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	20	compound	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	type	type	NN	NN	_	15	nmod	_	_
21	1	1	CD	CD	_	20	nummod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	HIV-1	hiv-1	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	goal	goal	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	study	study	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	determine	determine	VB	VB	_	7	xcomp	_	_
10	whether	whether	IN	IN	_	29	mark	_	_
11	the	the	DT	DT	_	15	det	_	_
12	mycobacterial	mycobacterial	JJ	JJ	_	13	amod	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	wall	wall	NN	NN	_	15	compound	_	_
15	component	component	NN	NN	_	29	nsubj	_	_
16	mannose-capped	mannose-capped	JJ	JJ	_	17	amod	_	_
17	lipoarabinomannan	lipoarabinomannan	NN	NN	_	15	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ManLAM	manlam	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	of	of	IN	IN	_	23	case	_	_
22	Mycobacterium	mycobacterium	FW	FW	_	23	compound	_	_
23	tuberculosis	tuberculosis	FW	FW	_	17	nmod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	M.	m.	FW	FW	_	26	compound	_	_
26	tuberculosis	tuberculosis	FW	FW	_	23	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	could	could	MD	MD	_	29	aux	_	_
29	activate	activate	VB	VB	_	9	ccomp	_	_
30	transcription	transcription	NN	NN	_	29	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	HIV-1	hiv-1	NN	NN	_	30	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	29	nmod	_	_
36	with	with	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	use	use	NN	NN	_	29	nmod	_	_
39	of	of	IN	IN	_	45	case	_	_
40	an	a	DT	DT	_	45	det	_	_
41	in	in	FW	FW	_	45	amod	_	_
42	vitro	vitro	FW	FW	_	41	dep	_	_
43	cell	cell	NN	NN	_	45	compound	_	_
44	culture	culture	NN	NN	_	45	compound	_	_
45	system	system	NN	NN	_	38	nmod	_	_
46	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	of	of	IN	IN	_	6	case	_	_
5	prime	prime	JJ	JJ	_	6	amod	_	_
6	importance	importance	NN	NN	_	0	root	_	_
7	considering	consider	VBG	VBG	_	12	case	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	CD4-expressing	cd4-expressing	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	12	nsubj	_	_
12	represent	represent	VBP	VBP	_	6	advcl	_	_
13	the	the	DT	DT	_	16	det	_	_
14	major	major	JJ	JJ	_	16	amod	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	reservoir	reservoir	NN	NN	_	12	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
20	blood	blood	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	infected	infected	JJ	JJ	_	23	amod	_	_
23	individuals	individual	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	5	det	_	_
3	1G5	1g5	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	1	dobj	_	_
6	harbouring	harbour	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	luciferase	luciferase	NN	NN	_	10	compound	_	_
9	reporter	reporter	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	dobj	_	_
11	under	under	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	control	control	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	HIV-1	hiv-1	NN	NN	_	17	compound	_	_
17	LTR	ltr	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	1	punct	_	_
19	it	it	PRP	PRP	_	22	nsubjpass	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	first	first	RB	RB	_	22	advmod	_	_
22	found	find	VBN	VBN	_	1	parataxis	_	_
23	that	that	IN	IN	_	37	mark	_	_
24	culture	culture	NN	NN	_	26	compound	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	filtrates	filtrate	NNS	NNS	_	37	nsubj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CFP	cfp	NNS	NNS	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	from	from	IN	IN	_	32	case	_	_
31	M.	m.	FW	FW	_	32	compound	_	_
32	tuberculosis	tuberculosis	FW	FW	_	26	nmod	_	_
33	or	or	CC	CC	_	26	cc	_	_
34	purified	purify	VBN	VBN	_	35	amod	_	_
35	ManLAM	manlam	NN	NN	_	26	conj	_	_
36	could	could	MD	MD	_	37	aux	_	_
37	activate	activate	VB	VB	_	22	ccomp	_	_
38	HIV-1	hiv-1	NN	NN	_	40	compound	_	_
39	LTR-dependent	ltr-dependent	JJ	JJ	_	40	amod	_	_
40	gene	gene	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	37	dobj	_	_
42	unlike	unlike	IN	IN	_	46	case	_	_
43	similarly	similarly	RB	RB	_	44	advmod	_	_
44	prepared	prepare	VBN	VBN	_	46	amod	_	_
45	CFP	cfp	NN	NN	_	46	compound	_	_
46	extracts	extract	NNS	NNS	_	37	nmod	_	_
47	devoid	devoid	JJ	JJ	_	46	amod	_	_
48	of	of	IN	IN	_	49	case	_	_
49	ManLAM	manlam	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	implication	implication	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	protein	protein	NN	NN	_	8	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
6	kinase	kinase	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	2	nmod	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	8	punct	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	8	appos	_	_
14	and/or	and/or	CC	CC	_	13	cc	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	kinase	kinase	NN	NN	_	17	compound	_	_
17	C	c	NN	NN	_	13	conj	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	highlighted	highlight	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	abrogation	abrogation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	ManLAM-mediated	manlam-mediated	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
29	LTR-driven	ltr-driven	JJ	JJ	_	30	amod	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	26	nmod	_	_
32	using	use	VBG	VBG	_	22	dep	_	_
33	herbimycin	herbimycin	NN	NN	_	34	compound	_	_
34	A	a	NN	NN	_	32	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	H7	h7	NN	NN	_	34	conj	_	_
37	.	.	.	.	_	19	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	using	use	VBG	VBG	_	4	xcomp	_	_
7	electrophoresis	electrophoresis	NN	NN	_	10	compound	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assays	assay	NNS	NNS	_	6	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	M.	m.	FW	FW	_	15	compound	_	_
14	tuberculosis	tuberculosis	FW	FW	_	15	compound	_	_
15	ManLAM	manlam	NN	NN	_	16	nsubj	_	_
16	led	lead	VBD	VBD	_	4	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
20	translocation	translocation	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	transcription	transcription	NN	NN	_	25	compound	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	M.	m.	FW	FW	_	3	compound	_	_
2	tuberculosis	tuberculosis	FW	FW	_	3	compound	_	_
3	ManLAM	manlam	NN	NN	_	4	nsubj	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	clear	clear	JJ	JJ	_	7	amod	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	luciferase	luciferase	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	placed	place	VBN	VBN	_	11	acl	_	_
13	under	under	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	control	control	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	wild-type	wild-type	JJ	JJ	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	but	but	CC	CC	_	18	cc	_	_
21	not	not	RB	RB	_	27	neg	_	_
22	the	the	DT	DT	_	27	det	_	_
23	kappaB-mutated	kappab-mutated	JJ	JJ	_	27	amod	_	_
24	,	,	,	,	_	27	punct	_	_
25	HIV-1	hiv-1	NN	NN	_	27	dep	_	_
26	LTR	ltr	NN	NN	_	27	compound	_	_
27	region	region	NN	NN	_	18	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	ManLAM-mediated	manlam-mediated	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	LTR	ltr	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	independent	independent	JJ	JJ	_	11	xcomp	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	autocrine	autocrine	JJ	JJ	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	paracrine	paracrine	JJ	JJ	_	17	conj	_	_
20	action	action	NN	NN	_	17	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	endogenous	endogenous	JJ	JJ	_	23	amod	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	M.	m.	FW	FW	_	6	compound	_	_
6	tuberculosis	tuberculosis	FW	FW	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	upregulate	upregulate	VB	VB	_	3	ccomp	_	_
9	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	thus	thus	RB	RB	_	17	advmod	_	_
17	have	have	VB	VB	_	8	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	potential	potential	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	influence	influence	VB	VB	_	19	acl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	pathogenesis	pathogenesis	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
26	infection	infection	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	IL-4-dependent	il-4-dependent	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TGF-alpha	tgf-alpha	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TGF-beta1	tgf-beta1	NN	NN	_	4	conj	_	_
7	expression	expression	NN	NN	_	4	dep	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	eosinophils	eosinophil	NNS	NNS	_	4	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	TGFs	tgf	NNS	NNS	_	2	nsubj	_	_
2	play	play	VBP	VBP	_	0	root	_	_
3	important	important	JJ	JJ	_	4	amod	_	_
4	roles	role	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	wound	wound	NN	NN	_	7	compound	_	_
7	healing	healing	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	carcinogenesis	carcinogenesis	NN	NN	_	7	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	eosinophils	eosinophil	NNS	NNS	_	12	nsubj	_	_
7	infiltrating	infiltrate	VBG	VBG	_	6	acl	_	_
8	into	into	IN	IN	_	11	case	_	_
9	different	different	JJ	JJ	_	11	amod	_	_
10	pathologic	pathologic	JJ	JJ	_	9	dep	_	_
11	processes	process	NNS	NNS	_	7	nmod	_	_
12	elaborate	elaborate	VBP	VBP	_	4	ccomp	_	_
13	TGF-alpha	tgf-alpha	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	TGF-beta1	tgf-beta1	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	7	nsubjpass	_	_
2	infiltrating	infiltrate	VBG	VBG	_	1	acl	_	_
3	hamster	hamster	NN	NN	_	5	compound	_	_
4	cutaneous	cutaneous	JJ	JJ	_	5	amod	_	_
5	wounds	wound	NNS	NNS	_	2	dobj	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	express	express	VB	VB	_	7	xcomp	_	_
10	TGFs	tgf	NNS	NNS	_	9	dobj	_	_
11	sequentially	sequentially	RB	RB	_	9	advmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	biologic	biologic	JJ	JJ	_	9	amod	_	_
9	mediators	mediator	NNS	NNS	_	6	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	regulate	regulate	VB	VB	_	9	acl:relcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TGF-alpha	tgf-alpha	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	-beta1	-beta1	NN	NN	_	16	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	eosinophils	eosinophil	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
7	blood	blood	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	healthy	healthy	JJ	JJ	_	10	amod	_	_
10	donors	donor	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	cultured	culture	VBN	VBN	_	3	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	absence	absence	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	presence	presence	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-3	il-3	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	IL-4	il-4	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	IL-5	il-5	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Cells	cell	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	in	in	FW	FW	_	7	amod	_	_
6	situ	situ	FW	FW	_	5	dep	_	_
7	hybridization	hybridization	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immunohistochemistry	immunohistochemistry	NN	NN	_	7	conj	_	_
10	.	.	.	.	_	3	punct	_	_

1	Supernatants	supernatant	NNS	NNS	_	6	nsubjpass	_	_
2	from	from	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	cultures	culture	NNS	NNS	_	1	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	assayed	assay	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	secreted	secrete	VBN	VBN	_	9	amod	_	_
9	TGF-alpha	tgf-alpha	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	TGF-beta1	tgf-beta1	NN	NN	_	9	conj	_	_
12	using	use	VBG	VBG	_	6	xcomp	_	_
13	TGF-specific	tgf-specific	JJ	JJ	_	14	amod	_	_
14	ELISAs	elisa	NNS	NNS	_	12	dobj	_	_
15	.	.	.	.	_	6	punct	_	_

1	IL-3	il-3	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	IL-4	il-4	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	IL-5	il-5	NN	NN	_	1	conj	_	_
7	independently	independently	RB	RB	_	8	advmod	_	_
8	up-regulated	up-regulate	VBD	VBD	_	0	root	_	_
9	TGF-beta1	tgf-beta1	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	product	product	NN	NN	_	10	conj	_	_
13	expression	expression	NN	NN	_	10	dep	_	_
14	by	by	IN	IN	_	15	case	_	_
15	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	all	all	DT	DT	_	18	det	_	_
18	donors	donor	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	TGF-alpha	tgf-alpha	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	8	nsubjpass	_	_
5	by	by	IN	IN	_	6	case	_	_
6	eosinophils	eosinophil	NNS	NNS	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-3	il-3	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-5	il-5	NN	NN	_	10	conj	_	_
13	but	but	CC	CC	_	8	cc	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	down-regulated	down-regulate	VBN	VBN	_	8	conj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IL-4	il-4	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Consistent	consistent	JJ	JJ	_	16	advmod	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	regulate	regulate	VB	VB	_	4	acl	_	_
9	eosinophil	eosinophil	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	8	dobj	_	_
11	,	,	,	,	_	16	punct	_	_
12	IL-4	il-4	NN	NN	_	14	compound	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	molecules	molecule	NNS	NNS	_	16	nsubj	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	present	present	JJ	JJ	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	eosinophils	eosinophil	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	14	nsubj	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	IL-4	il-4	NN	NN	_	7	nsubj	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	differentially	differentially	RB	RB	_	7	advmod	_	_
7	regulate	regulate	VB	VB	_	2	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TGF-alpha	tgf-alpha	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	TGF-beta1	tgf-beta1	NN	NN	_	11	conj	_	_
14	suggests	suggest	VBZ	VBZ	_	0	root	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	IL-4	il-4	NN	NN	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	serve	serve	VB	VB	_	14	ccomp	_	_
19	as	as	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	physiologic	physiologic	JJ	JJ	_	23	amod	_	_
22	molecular	molecular	JJ	JJ	_	23	amod	_	_
23	switch	switch	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	TGF	tgf	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	by	by	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	infiltrating	infiltrate	VBG	VBG	_	30	amod	_	_
30	eosinophils	eosinophil	NNS	NNS	_	26	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	wound	wound	NN	NN	_	33	compound	_	_
33	healing	healing	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	carcinogenesis	carcinogenesis	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	14	punct	_	_

1	Minimal	minimal	JJ	JJ	_	3	amod	_	_
2	residual	residual	JJ	JJ	_	3	amod	_	_
3	disease	disease	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	acute	acute	JJ	JJ	_	7	amod	_	_
6	myelogenous	myelogenous	JJ	JJ	_	7	amod	_	_
7	leukemia	leukemia	NN	NN	_	3	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	PML/RAR	pml/rar	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	AML1/ETO	aml1/eto	NN	NN	_	10	conj	_	_
13	mRNA	mrna	NN	NN	_	10	dep	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	phenotypic	phenotypic	JJ	JJ	_	16	amod	_	_
16	analysis	analysis	NN	NN	_	3	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	possible	possible	JJ	JJ	_	19	amod	_	_
19	T	t	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	natural	natural	JJ	JJ	_	22	amod	_	_
22	killer	killer	NN	NN	_	19	conj	_	_
23	cells	cell	NNS	NNS	_	19	dep	_	_
24	in	in	IN	IN	_	26	case	_	_
25	bone	bone	NN	NN	_	26	compound	_	_
26	marrow	marrow	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	minimal	minimal	JJ	JJ	_	6	amod	_	_
5	residual	residual	JJ	JJ	_	6	amod	_	_
6	disease	disease	NN	NN	_	3	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	MRD	mrd	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	of	of	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	6	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	acute	acute	JJ	JJ	_	15	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	leukemia	leukemia	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	AML	aml	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	who	who	WP	WP	_	20	nsubj	_	_
20	have	have	VBP	VBP	_	11	acl:relcl	_	_
21	PML/RAR	pml/rar	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	20	dobj	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	AML1/ETO	aml1/eto	NN	NN	_	22	conj	_	_
25	as	as	RB	RB	_	6	cc	_	_
26	well	well	RB	RB	_	25	mwe	_	_
27	as	as	IN	IN	_	25	mwe	_	_
28	the	the	DT	DT	_	30	det	_	_
29	phenotypic	phenotypic	JJ	JJ	_	30	amod	_	_
30	analysis	analysis	NN	NN	_	6	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	lymphocyte	lymphocyte	NN	NN	_	33	compound	_	_
33	subsets	subset	NNS	NNS	_	30	nmod	_	_
34	involved	involve	VBN	VBN	_	33	acl	_	_
35	in	in	IN	IN	_	37	case	_	_
36	antitumor	antitumor	NN	NN	_	37	compound	_	_
37	immunity	immunity	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Eight	eight	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	28	nsubjpass	_	_
3	in	in	IN	IN	_	4	case	_	_
4	long-term	long-term	JJ	JJ	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LT	lt	JJ	JJ	_	4	dep	_	_
7	;	;	:	:	_	6	punct	_	_
8	3	3	CD	CD	_	10	compound	_	_
9	to	to	TO	TO	_	10	dep	_	_
10	15	15	CD	CD	_	11	nummod	_	_
11	years	year	NNS	NNS	_	6	dep	_	_
12	)	)	-RRB-	-RRB-	_	6	punct	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	15	15	CD	CD	_	15	nummod	_	_
15	patients	patient	NNS	NNS	_	2	conj	_	_
16	in	in	IN	IN	_	26	case	_	_
17	short-term	short-term	JJ	JJ	_	26	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ST	st	JJ	JJ	_	17	dep	_	_
20	;	;	:	:	_	19	punct	_	_
21	up	up	RB	RB	_	23	advmod	_	_
22	to	to	TO	TO	_	23	dep	_	_
23	3	3	CD	CD	_	24	nummod	_	_
24	years	years	NN	NN	_	19	dep	_	_
25	)	)	-RRB-	-RRB-	_	19	punct	_	_
26	remission	remission	NN	NN	_	15	nmod	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	studied	study	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	Using	use	VBG	VBG	_	0	root	_	_
2	the	the	DT	DT	_	6	det	_	_
3	reverse	reverse	JJ	JJ	_	6	amod	_	_
4	transcription-polymerase	transcription-polymerase	NN	NN	_	6	compound	_	_
5	chain	chain	NN	NN	_	6	compound	_	_
6	reaction	reaction	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	RT	rt	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	assay	assay	NN	NN	_	1	dobj	_	_
11	,	,	,	,	_	1	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	limit	limit	NN	NN	_	19	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	detection	detection	NN	NN	_	13	nmod	_	_
16	was	be	VBD	VBD	_	19	cop	_	_
17	10(-5)	10(-5)	CD	CD	_	19	compound	_	_
18	to	to	TO	TO	_	19	dep	_	_
19	10(-6)	10(-6)	CD	CD	_	1	parataxis	_	_
20	for	for	IN	IN	_	23	case	_	_
21	PML/RAR	pml/rar	NN	NN	_	23	compound	_	_
22	alpha	alpha	NN	NN	_	23	compound	_	_
23	transcript	transcript	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	10(-4)	10(-4)	CD	CD	_	27	compound	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	10(-5)	10(-5)	CD	CD	_	19	conj	_	_
28	for	for	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	AML1/ETO	aml1/eto	NN	NN	_	31	compound	_	_
31	transcript	transcript	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	Simultaneously	simultaneously	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	subsets	subset	NNS	NNS	_	23	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	NK	nk	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	conj	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	dep	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	blood	blood	NN	NN	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PB	pb	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	bone	bone	NN	NN	_	18	compound	_	_
18	marrow	marrow	NN	NN	_	12	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	BM	bm	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	investigated	investigate	VBN	VBN	_	0	root	_	_
24	by	by	IN	IN	_	27	case	_	_
25	flow	flow	NN	NN	_	27	compound	_	_
26	cytometric	cytometric	JJ	JJ	_	27	amod	_	_
27	analysis	analysis	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	23	punct	_	_

1	Four	four	CD	CD	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	eight	eight	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	LT	lt	JJ	JJ	_	5	nmod	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	7	7	CD	CD	_	1	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	15	15	CD	CD	_	13	nummod	_	_
13	patients	patient	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	ST	st	JJ	JJ	_	16	amod	_	_
16	remission	remission	NN	NN	_	13	nmod	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	MRD-positive	mrd-positive	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Although	although	IN	IN	_	11	mark	_	_
2	all	all	DT	DT	_	4	det	_	_
3	MRD-positive	mrd-positive	JJ	JJ	_	4	amod	_	_
4	patients	patient	NNS	NNS	_	11	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	LT	lt	JJ	JJ	_	7	amod	_	_
7	remission	remission	NN	NN	_	4	nmod	_	_
8	are	be	VBP	VBP	_	11	cop	_	_
9	still	still	RB	RB	_	11	advmod	_	_
10	until	until	IN	IN	_	11	case	_	_
11	now	now	RB	RB	_	14	advcl	_	_
12	event-free	event-free	RB	RB	_	11	advmod	_	_
13	,	,	,	,	_	14	punct	_	_
14	3	3	CD	CD	_	0	root	_	_
15	of	of	IN	IN	_	22	case	_	_
16	the	the	DT	DT	_	22	det	_	_
17	7	7	CD	CD	_	22	nummod	_	_
18	MRD-positive	mrd-positive	JJ	JJ	_	22	amod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	MRD+	mrd+	JJ	JJ	_	18	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	patients	patient	NNS	NNS	_	14	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	ST	st	JJ	JJ	_	25	amod	_	_
25	remission	remission	NN	NN	_	22	nmod	_	_
26	soon	soon	IN	IN	_	27	case	_	_
27	relapsed	relapsed	NN	NN	_	14	advcl	_	_
28	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	total	total	JJ	JJ	_	3	amod	_	_
3	populations	population	NNS	NNS	_	37	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CD4+	cd4+	JJ	JJ	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	CD8+	cd8+	JJ	JJ	_	5	conj	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	CD56+	cd56+	JJ	JJ	_	5	conj	_	_
10	-LSB-	-lsb-	-LRB-	-LRB-	_	12	punct	_	_
11	possible	possible	JJ	JJ	_	12	amod	_	_
12	T-cell	t-cell	NN	NN	_	3	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	natural	natural	JJ	JJ	_	15	amod	_	_
15	killer	killer	NN	NN	_	12	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	T/NK	t/nk	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	populations	population	NNS	NNS	_	12	dep	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	12	punct	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	BM	bm	NN	NN	_	3	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	ST	st	JJ	JJ	_	26	amod	_	_
26	patients	patient	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	MRD+/LT	mrd+/lt	JJ	JJ	_	29	amod	_	_
29	patients	patient	NNS	NNS	_	26	conj	_	_
30	were	be	VBD	VBD	_	37	cop	_	_
31	significantly	significantly	RB	RB	_	37	advmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	p	p	NN	NN	_	31	dep	_	_
34	&lt;	&lt;	JJR	JJR	_	33	amod	_	_
35	.01	.01	CD	CD	_	34	dep	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	low	low	JJ	JJ	_	0	root	_	_
38	.	.	.	.	_	37	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	CD8+	cd8+	JJ	JJ	_	5	nsubj	_	_
3	CD28+	cd28+	JJ	JJ	_	2	dep	_	_
4	population	population	NN	NN	_	2	dep	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	same	same	JJ	JJ	_	8	amod	_	_
8	tendency	tendency	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	p	p	NN	NN	_	8	dep	_	_
11	&lt;	&lt;	JJR	JJR	_	10	amod	_	_
12	.01-.02	.01-.02	CD	CD	_	11	dep	_	_
13	)	)	-RRB-	-RRB-	_	10	punct	_	_
14	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	T/NK	t/nk	NN	NN	_	3	compound	_	_
3	subsets	subset	NNS	NNS	_	17	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	BM	bm	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	16	case	_	_
8	MRD-negative	mrd-negative	JJ	JJ	_	12	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MRD-	mrd-	JJ	JJ	_	8	dep	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	LT	lt	JJ	JJ	_	16	amod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	MRD-/LT	mrd-/lt	JJ	JJ	_	12	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	patients	patient	NNS	NNS	_	6	nmod	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	similar	similar	JJ	JJ	_	19	amod	_	_
19	numbers	number	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	cells	cell	NNS	NNS	_	19	nmod	_	_
22	as	as	IN	IN	_	24	mark	_	_
23	normal	normal	JJ	JJ	_	24	amod	_	_
24	volunteers	volunteer	NNS	NNS	_	19	dep	_	_
25	.	.	.	.	_	17	punct	_	_

1	Basically	basically	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	total	total	JJ	JJ	_	5	amod	_	_
5	percentage	percentage	NN	NN	_	19	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	CD4+	cd4+	JJ	JJ	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	CD8+	cd8+	JJ	JJ	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	CD56+	cd56+	JJ	JJ	_	8	conj	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	populations	population	NNS	NNS	_	8	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	BM	bm	NN	NN	_	8	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	increased	increase	VBN	VBN	_	0	root	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	following	follow	VBG	VBG	_	24	amod	_	_
24	order	order	NN	NN	_	19	conj	_	_
25	:	:	:	:	_	19	punct	_	_
26	MRD-/LT	mrd-/lt	JJ	JJ	_	27	amod	_	_
27	patients	patient	NNS	NNS	_	19	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	normal	normal	JJ	JJ	_	30	amod	_	_
30	volunteers	volunteer	NNS	NNS	_	27	conj	_	_
31	,	,	,	,	_	27	punct	_	_
32	MRD+/LT	mrd+/lt	JJ	JJ	_	33	amod	_	_
33	patients	patient	NNS	NNS	_	27	conj	_	_
34	and	and	CC	CC	_	27	cc	_	_
35	MRD+	mrd+	JJ	JJ	_	27	conj	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	-/ST	-/st	JJ	JJ	_	35	conj	_	_
38	patients	patient	NNS	NNS	_	35	dep	_	_
39	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	percentages	percentage	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	T/NK-cell	t/nk-cell	NN	NN	_	6	compound	_	_
6	subsets	subset	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	PB	pb	NN	NN	_	6	nmod	_	_
10	were	be	VBD	VBD	_	13	cop	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	different	different	JJ	JJ	_	0	root	_	_
14	among	among	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	groups	group	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	Thus	thus	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	difference	difference	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	possible	possible	JJ	JJ	_	9	amod	_	_
8	T/NK-cell	t/nk-cell	JJ	JJ	_	9	compound	_	_
9	phenotype	phenotype	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	BM	bm	NN	NN	_	9	nmod	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	strongly	strongly	RB	RB	_	15	advmod	_	_
15	influence	influence	VB	VB	_	0	root	_	_
16	clinical	clinical	JJ	JJ	_	15	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	molecular	molecular	JJ	JJ	_	16	conj	_	_
19	remission	remission	NN	NN	_	16	dep	_	_
20	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	still	still	RB	RB	_	4	advmod	_	_
4	remain	remain	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	4	xcomp	_	_
8	by	by	IN	IN	_	10	case	_	_
9	further	further	JJ	JJ	_	10	amod	_	_
10	studies	study	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	functional	functional	JJ	JJ	_	15	amod	_	_
14	anti-tumor	anti-tumor	JJ	JJ	_	13	dep	_	_
15	immunity	immunity	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	T/NK	t/nk	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	AML	aml	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	remission	remission	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Janus	janus	NN	NN	_	7	compound	_	_
6	kinase-STAT	kinase-stat	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	biologic	biologic	JJ	JJ	_	10	amod	_	_
10	function	function	NN	NN	_	2	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-13	il-13	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	primary	primary	JJ	JJ	_	16	amod	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	NK	nk	NN	NN	_	2	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	T	t	NN	NN	_	16	conj	_	_
19	cells	cell	NNS	NNS	_	16	dep	_	_
20	:	:	:	:	_	2	punct	_	_
21	a	a	DT	DT	_	23	det	_	_
22	comparative	comparative	JJ	JJ	_	23	amod	_	_
23	study	study	NN	NN	_	2	dep	_	_
24	with	with	IN	IN	_	25	case	_	_
25	IL-4	il-4	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	IL-13	il-13	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	cytokine	cytokine	NN	NN	_	1	appos	_	_
5	similar	similar	JJ	JJ	_	4	amod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	IL-4	il-4	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	a	a	DT	DT	_	11	det	_	_
11	regulator	regulator	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cell	cell	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	monocyte	monocyte	NN	NN	_	18	compound	_	_
18	functions	function	NNS	NNS	_	15	conj	_	_
19	.	.	.	.	_	11	punct	_	_

1	Biologic	biologic	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IL-13	il-13	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	primary	primary	JJ	JJ	_	8	amod	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	NK	nk	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	T	t	NN	NN	_	8	conj	_	_
11	cells	cell	NNS	NNS	_	8	dep	_	_
12	have	have	VBP	VBP	_	16	aux	_	_
13	not	not	RB	RB	_	16	neg	_	_
14	been	be	VBN	VBN	_	16	auxpass	_	_
15	well	well	RB	RB	_	16	advmod	_	_
16	defined	define	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	,	,	,	,	_	17	punct	_	_
5	in	in	IN	IN	_	8	case	_	_
6	primary	primary	JJ	JJ	_	8	amod	_	_
7	NK	nk	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	17	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	IL-13	il-13	NN	NN	_	17	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	10	cc	_	_
14	IL-4	il-4	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	induce	induce	VB	VB	_	2	ccomp	_	_
18	low	low	JJ	JJ	_	19	amod	_	_
19	levels	level	NNS	NNS	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	secretion	secretion	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	NK	nk	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	costimulated	costimulate	VBN	VBN	_	13	advcl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	IL-13	il-13	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-2	il-2	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	13	punct	_	_
11	IL-13	il-13	NN	NN	_	13	nsubj	_	_
12	generally	generally	RB	RB	_	13	advmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	two	two	CD	CD	_	16	nummod	_	_
16	types	type	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	reactivity	reactivity	NN	NN	_	16	nmod	_	_
19	:	:	:	:	_	13	punct	_	_
20	IL-13	il-13	NN	NN	_	21	nsubj	_	_
21	synergized	synergize	VBD	VBD	_	13	parataxis	_	_
22	with	with	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	stimulate	stimulate	VB	VB	_	21	xcomp	_	_
26	IFN-gamma	ifn-gamma	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	25	dobj	_	_
28	or	or	CC	CC	_	21	cc	_	_
29	it	it	PRP	PRP	_	31	nsubj	_	_
30	modestly	modestly	RB	RB	_	31	advmod	_	_
31	inhibited	inhibit	VBD	VBD	_	21	conj	_	_
32	IL-2-mediated	il-2-mediated	JJ	JJ	_	34	amod	_	_
33	IFN-gamma	ifn-gamma	NN	NN	_	34	compound	_	_
34	production	production	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	both	both	DT	DT	_	3	det	_	_
3	types	type	NNS	NNS	_	18	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	donors	donor	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	18	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effect	effect	NN	NN	_	18	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IL-13	il-13	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	14	case	_	_
12	IL-2-induced	il-2-induced	JJ	JJ	_	14	amod	_	_
13	IFN-gamma	ifn-gamma	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	8	nmod	_	_
15	was	be	VBD	VBD	_	18	cop	_	_
16	in	in	IN	IN	_	18	case	_	_
17	marked	marked	JJ	JJ	_	18	amod	_	_
18	contrast	contrast	NN	NN	_	0	root	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	strong	strong	JJ	JJ	_	22	amod	_	_
22	inhibition	inhibition	NN	NN	_	18	nmod	_	_
23	seen	see	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	25	case	_	_
25	IL-4	il-4	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	NK	nk	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	18	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-13	il-13	NN	NN	_	4	nsubj	_	_
4	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
5	IL-2-induced	il-2-induced	JJ	JJ	_	6	amod	_	_
6	NK	nk	NN	NN	_	4	dobj	_	_
7	cytolytic	cytolytic	JJ	JJ	_	6	dep	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	proliferative	proliferative	JJ	JJ	_	6	conj	_	_
10	activities	activity	NNS	NNS	_	6	dep	_	_
11	although	although	IN	IN	_	13	mark	_	_
12	less	less	JJR	JJR	_	13	dep	_	_
13	efficiently	efficiently	RB	RB	_	4	advcl	_	_
14	than	than	IN	IN	_	15	mark	_	_
15	IL-4	il-4	NN	NN	_	13	dep	_	_
16	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	IL-13	il-13	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
7	anti-CD3	anti-cd3	JJ	JJ	_	8	amod	_	_
8	mAb/IL-2-	mab/il-2-	NN	NN	_	6	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	PHA-mediated	pha-mediated	JJ	JJ	_	8	conj	_	_
11	IFN-gamma	ifn-gamma	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	8	dep	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	enhances	enhance	VBZ	VBZ	_	6	conj	_	_
15	cytolytic	cytolytic	JJ	JJ	_	16	amod	_	_
16	potential	potential	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	IL-13	il-13	NN	NN	_	11	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	like	like	IN	IN	_	9	case	_	_
9	IL-4	il-4	NN	NN	_	11	nmod	_	_
10	,	,	,	,	_	11	punct	_	_
11	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
12	distinct	distinct	JJ	JJ	_	15	amod	_	_
13	STAT6-DNA	stat6-dna	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	complexes	complex	NNS	NNS	_	11	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	STAT6	stat6	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Janus	janus	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	20	conj	_	_
24	3	3	CD	CD	_	23	nummod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	JAK3	jak3	NN	NN	_	23	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	in	in	IN	IN	_	29	case	_	_
29	NK	nk	NN	NN	_	11	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	conj	_	_
33	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	Abs	ab	NNS	NNS	_	11	nsubj	_	_
5	directed	direct	VBN	VBN	_	4	acl	_	_
6	against	against	IN	IN	_	8	case	_	_
7	unique	unique	JJ	JJ	_	8	amod	_	_
8	domains	domain	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT6	stat6	NN	NN	_	8	nmod	_	_
11	have	have	VBP	VBP	_	2	ccomp	_	_
12	differential	differential	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	complexes	complex	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	but	but	CC	CC	_	18	cc	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	in	in	IN	IN	_	23	case	_	_
22	NK	nk	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	conj	_	_
24	,	,	,	,	_	11	punct	_	_
25	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
26	different	different	JJ	JJ	_	28	amod	_	_
27	STAT6	stat6	NN	NN	_	28	compound	_	_
28	isoforms	isoform	NNS	NNS	_	25	dobj	_	_
29	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	IL-13	il-13	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-4	il-4	NN	NN	_	5	conj	_	_
8	have	have	VBP	VBP	_	3	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	ability	ability	NN	NN	_	8	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	regulate	regulate	VB	VB	_	10	acl	_	_
13	NK	nk	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	13	conj	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	dep	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	IL-	il-	NN	NN	_	25	nsubj	_	_
21	13	13	CD	CD	_	20	nummod	_	_
22	is	be	VBZ	VBZ	_	25	cop	_	_
23	a	a	DT	DT	_	25	det	_	_
24	potent	potent	JJ	JJ	_	25	amod	_	_
25	regulator	regulator	NN	NN	_	8	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	STAT6	stat6	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	JAK3	jak3	NN	NN	_	27	conj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	these	these	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	types	type	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	function	function	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Stat1	stat1	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Stat3	stat3	NN	NN	_	5	conj	_	_
8	proteins	protein	NNS	NNS	_	5	dep	_	_
9	in	in	IN	IN	_	12	case	_	_
10	erythropoietin-induced	erythropoietin-induced	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	leukemia	leukemia	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	line	line	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	determined	determine	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	erythropoietin	erythropoietin	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EPO	epo	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
10	3	3	CD	CD	_	11	nummod	_	_
11	members	member	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	23	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	signal	signal	NN	NN	_	23	compound	_	_
15	transducer	transducer	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	activator	activator	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	transcription	transcription	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	STAT	stat	NN	NN	_	14	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	family	family	NN	NN	_	11	nmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	Stat1alpha	stat1alpha	NN	NN	_	11	appos	_	_
26	,	,	,	,	_	25	punct	_	_
27	Stat3	stat3	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	Stat5	stat5	NN	NN	_	25	conj	_	_
31	,	,	,	,	_	9	punct	_	_
32	in	in	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	human	human	JJ	JJ	_	37	amod	_	_
35	EPO-dependent	epo-dependent	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	9	nmod	_	_
38	,	,	,	,	_	37	punct	_	_
39	UT-7	ut-7	NN	NN	_	37	appos	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	UT-7/EPO	ut-7/epo	NN	NN	_	39	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	Kirito	Kirito	NNP	NNP	_	3	dep	_	_
44	et	et	FW	FW	_	43	compound	_	_
45	al	al	FW	FW	_	43	dep	_	_
46	,	,	,	,	_	43	punct	_	_
47	J	J	NNP	NNP	_	49	compound	_	_
48	Biol	Biol	NNP	NNP	_	49	compound	_	_
49	Chem	Chem	NNP	NNP	_	43	appos	_	_
50	272	272	CD	CD	_	49	nummod	_	_
51	:	:	:	:	_	43	punct	_	_
52	16507	16507	CD	CD	_	43	dep	_	_
53	,	,	,	,	_	43	punct	_	_
54	1997	1997	CD	CD	_	43	amod	_	_
55	)	)	-RRB-	-RRB-	_	43	punct	_	_
56	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	Stat1alpha	stat1alpha	NN	NN	_	15	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	8	cc	_	_
12	Stat3	stat3	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	involved	involve	VBN	VBN	_	6	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	EPO-induced	epo-induced	JJ	JJ	_	19	amod	_	_
18	cellular	cellular	JJ	JJ	_	19	amod	_	_
19	proliferation	proliferation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	roles	role	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Stat1alpha	stat1alpha	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Stat3	stat3	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	EPO-induced	epo-induced	JJ	JJ	_	16	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	UT-7/GM	ut-7/gm	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	model	model	NN	NN	_	7	compound	_	_
7	system	system	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	because	because	IN	IN	_	14	mark	_	_
10	this	this	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	differentiate	differentiate	VB	VB	_	3	advcl	_	_
15	into	into	IN	IN	_	17	case	_	_
16	erythroid-lineage	erythroid-lineage	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	EPO	epo	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	14	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	Komatsu	komatsu	NN	NN	_	3	dep	_	_
23	et	et	FW	FW	_	22	compound	_	_
24	al	al	FW	FW	_	22	dep	_	_
25	,	,	,	,	_	22	punct	_	_
26	Blood	Blood	NNP	NNP	_	22	appos	_	_
27	89	89	CD	CD	_	26	nummod	_	_
28	:	:	:	:	_	22	punct	_	_
29	4021	4021	CD	CD	_	22	dep	_	_
30	,	,	,	,	_	22	punct	_	_
31	1997	1997	CD	CD	_	22	amod	_	_
32	)	)	-RRB-	-RRB-	_	22	punct	_	_
33	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	EPO	epo	NN	NN	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	activate	activate	VB	VB	_	2	ccomp	_	_
8	Stat1alpha	stat1alpha	NN	NN	_	7	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	Stat3	stat3	NN	NN	_	8	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	UT-7/GM	ut-7/gm	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Transfection	transfection	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	Stat1alpha	stat1alpha	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Stat3	stat3	NN	NN	_	6	conj	_	_
9	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	induction	induction	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	EPO	epo	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	gamma-globin	gamma-globin	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	erythroid-specific	erythroid-specific	JJ	JJ	_	19	amod	_	_
18	5-aminolevulinate	5-aminolevulinate	JJ	JJ	_	19	amod	_	_
19	synthetase	synthetase	NN	NN	_	15	conj	_	_
20	transcripts	transcript	NNS	NNS	_	15	dep	_	_
21	,	,	,	,	_	9	punct	_	_
22	resulting	result	VBG	VBG	_	9	advcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	reduction	reduction	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	percentage	percentage	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	hemoglobin-positive	hemoglobin-positive	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Dominant	dominant	JJ	JJ	_	3	amod	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	forms	form	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Stat1alpha	stat1alpha	NN	NN	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	Stat3	stat3	NN	NN	_	5	conj	_	_
8	promoted	promote	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	EPO-induced	epo-induced	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	UT-7/GM	ut-7/gm	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	even	even	RB	RB	_	20	advmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	8	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	24	amod	_	_
23	colony-stimulating	colony-stimulating	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	8	punct	_	_
26	although	although	IN	IN	_	30	mark	_	_
27	this	this	DT	DT	_	28	det	_	_
28	cytokine	cytokine	NN	NN	_	30	nsubj	_	_
29	never	never	RB	RB	_	30	neg	_	_
30	induced	induce	VBD	VBD	_	8	advcl	_	_
31	erythroid	erythroid	JJ	JJ	_	32	amod	_	_
32	differentiation	differentiation	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	parent	parent	JJ	JJ	_	37	amod	_	_
36	UT-7/GM	ut-7/gm	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	with	with	IN	IN	_	41	nmod	_	_
39	or	or	CC	CC	_	41	cc	_	_
40	without	without	IN	IN	_	41	conj	_	_
41	EPO	epo	NN	NN	_	30	nmod	_	_
42	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	cycle	cycle	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Stat1alpha	stat1alpha	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	11	cc	_	_
15	Stat3	stat3	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	shortened	shorten	VBD	VBD	_	5	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	period	period	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	G0/G1	g0/g1	NN	NN	_	22	compound	_	_
22	prolongation	prolongation	NN	NN	_	19	nmod	_	_
23	caused	cause	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	EPO	epo	NN	NN	_	26	compound	_	_
26	stimulation	stimulation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	1	parataxis	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	Stat1alpha	stat1alpha	NN	NN	_	11	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Stat3	stat3	NN	NN	_	8	conj	_	_
11	act	act	VBP	VBP	_	6	ccomp	_	_
12	as	as	IN	IN	_	14	case	_	_
13	negative	negative	JJ	JJ	_	14	amod	_	_
14	regulators	regulator	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	EPO-induced	epo-induced	JJ	JJ	_	18	amod	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Specifically	specifically	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Stat1alpha	stat1alpha	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	activate	activate	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	11	det	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	cycle-associated	cycle-associated	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	s	s	NNS	NNS	_	5	dobj	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	5	punct	_	_
14	leading	lead	VBG	VBG	_	5	advcl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	entry	entry	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	into	into	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	cycle	cycle	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	damaging	damaging	NN	NN	_	3	compound	_	_
3	agents	agent	NNS	NNS	_	4	nsubj	_	_
4	induce	induce	VBP	VBP	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Fas	fas	NN	NN	_	8	compound	_	_
8	ligand	ligand	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	subsequent	subsequent	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	via	via	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activation	activation	NN	NN	_	4	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	AP-1	ap-1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	10	nsubj	_	_
2	induced	induce	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	damage	damage	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	stresses	stress	NNS	NNS	_	5	conj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	proceed	proceed	VB	VB	_	0	root	_	_
11	via	via	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Fas	fas	NN	NN	_	15	compound	_	_
15	ligand	ligand	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	FasL	fasl	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	ligation	ligation	NN	NN	_	12	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	receptor	receptor	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	Fas	fas	NN	NN	_	23	appos	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CD95	cd95	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	activation	activation	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	4	nmod	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	9	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	AP-1	ap-1	NN	NN	_	11	conj	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	crucially	crucially	RB	RB	_	16	advmod	_	_
16	involved	involve	VBN	VBN	_	2	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	FasL	fasl	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	etoposide	etoposide	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	teniposide	teniposide	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	UV	uv	NN	NN	_	28	compound	_	_
28	irradiation	irradiation	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	nondegradable	nondegradable	JJ	JJ	_	3	amod	_	_
3	mutant	mutant	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	I	i	NN	NN	_	7	compound	_	_
6	kappa	kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	3	nmod	_	_
8	blocked	block	VBD	VBD	_	0	root	_	_
9	both	both	CC	CC	_	11	cc:preconj	_	_
10	FasL	fasl	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	apoptosis	apoptosis	NN	NN	_	11	conj	_	_
14	induced	induce	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	damage	damage	NN	NN	_	14	nmod	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	11	cc	_	_
20	Fas	fas	NN	NN	_	21	compound	_	_
21	ligation	ligation	NN	NN	_	11	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	stimuli	stimulus	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	stress-activated	stress-activated	JJ	JJ	_	8	amod	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	4	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	SAPK/JNK	sapk/jnk	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	8	acl:relcl	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	maximal	maximal	JJ	JJ	_	19	amod	_	_
19	induction	induction	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	1.2	1.2	CD	CD	_	3	compound	_	_
3	kb	kb	NN	NN	_	5	amod	_	_
4	FasL	fasl	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	responded	respond	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	damage	damage	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	as	as	RB	RB	_	9	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	coexpression	coexpression	NN	NN	_	9	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	p65	p65	NN	NN	_	17	compound	_	_
17	Rel	rel	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	Fos/Jun	fos/jun	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Mutations	mutation	NNS	NNS	_	11	nsubj	_	_
2	in	in	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	dep	_	_
4	relevant	relevant	JJ	JJ	_	6	amod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	sites	site	NNS	NNS	_	6	conj	_	_
11	eliminated	eliminate	VBD	VBD	_	0	root	_	_
12	these	these	DT	DT	_	13	det	_	_
13	responses	response	NNS	NNS	_	11	dobj	_	_
14	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	activation	activation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1	ap-1	NN	NN	_	6	conj	_	_
9	contributes	contribute	VBZ	VBZ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	stress-induced	stress-induced	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
13	via	via	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	FasL	fasl	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Uncoupling	uncoupling	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	nonreceptor	nonreceptor	JJ	JJ	_	5	amod	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	kinases	kinase	NNS	NNS	_	1	nmod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	PLC-gamma1	plc-gamma1	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	an	a	DT	DT	_	12	det	_	_
10	SLP-76-deficient	slp-76-deficient	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Activation	activation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	nonreceptor	nonreceptor	JJ	JJ	_	6	amod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	kinases	kinase	NNS	NNS	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PTKs	ptks	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	essential	essential	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	19	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TCR	tcr	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	responsiveness	responsiveness	NN	NN	_	11	nmod	_	_
20	;	;	:	:	_	11	punct	_	_
21	however	however	RB	RB	_	31	advmod	_	_
22	,	,	,	,	_	31	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	function	function	NN	NN	_	31	nsubj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	individual	individual	JJ	JJ	_	28	amod	_	_
27	PTK	ptk	NN	NN	_	28	compound	_	_
28	substrates	substrate	NNS	NNS	_	24	nmod	_	_
29	is	be	VBZ	VBZ	_	31	cop	_	_
30	often	often	RB	RB	_	31	advmod	_	_
31	uncertain	uncertain	JJ	JJ	_	11	parataxis	_	_
32	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	mutant	mutant	JJ	JJ	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	isolated	isolate	VBN	VBN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	lacked	lack	VBD	VBD	_	7	ccomp	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	SLP-76	slp-76	NN	NN	_	10	nmod	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	SH2	sh2	NN	NN	_	17	compound	_	_
15	domain-containing	domain-containing	JJ	JJ	_	17	amod	_	_
16	leukocyte	leukocyte	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	12	dep	_	_
18	of	of	IN	IN	_	20	case	_	_
19	76	76	CD	CD	_	20	nummod	_	_
20	kilodaltons	kilodalton	NNS	NNS	_	17	nmod	_	_
21	)	)	-RRB-	-RRB-	_	17	punct	_	_
22	,	,	,	,	_	12	punct	_	_
23	a	a	DT	DT	_	27	det	_	_
24	hematopoietically	hematopoietically	RB	RB	_	27	advmod	_	_
25	expressed	express	VBN	VBN	_	27	amod	_	_
26	adaptor	adaptor	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	12	appos	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	PTK	ptk	NN	NN	_	30	compound	_	_
30	substrate	substrate	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	7	punct	_	_

1	SLP-76	slp-76	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	8	case	_	_
6	TCR-induced	tcr-induced	JJ	JJ	_	8	amod	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	most	most	JJS	JJS	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	but	but	CC	CC	_	4	cc	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	4	conj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	optimal	optimal	JJ	JJ	_	19	amod	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	activation	activation	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	phospholipase	phospholipase	NN	NN	_	24	compound	_	_
24	C-gamma1	c-gamma1	NN	NN	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PLC-gamma1	plc-gamma1	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	21	punct	_	_
29	as	as	RB	RB	_	21	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	Ras	ras	NN	NN	_	34	compound	_	_
33	pathway	pathway	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	21	conj	_	_
35	.	.	.	.	_	4	punct	_	_

1	TCR-inducible	tcr-inducible	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	dependent	dependent	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	SLP-76	slp-76	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	coupling	coupling	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	TCR-regulated	tcr-regulated	JJ	JJ	_	6	amod	_	_
6	PTKs	ptks	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	10	case	_	_
8	downstream	downstream	JJ	JJ	_	10	amod	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	3	nmod	_	_
11	requires	require	VBZ	VBZ	_	0	root	_	_
12	SLP-76	slp-76	NN	NN	_	11	dobj	_	_
13	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	10	det	_	_
2	novel	novel	JJ	JJ	_	10	amod	_	_
3	retinoic	retinoic	JJ	JJ	_	5	amod	_	_
4	acid	acid	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	9	nmod:npmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	RAR	rar	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	-selective	-selective	JJ	JJ	_	10	amod	_	_
10	antagonist	antagonist	NN	NN	_	11	nsubj	_	_
11	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
12	differentiation	differentiation	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	apoptosis	apoptosis	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HL-60	hl-60	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	:	:	:	:	_	11	punct	_	_
19	implications	implication	NNS	NNS	_	11	dep	_	_
20	of	of	IN	IN	_	22	case	_	_
21	RARalpha-mediated	raralpha-mediated	JJ	JJ	_	22	amod	_	_
22	signals	signal	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
25	leukemic	leukemic	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	HL-60	hl-60	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	6	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	differentiate	differentiate	VB	VB	_	6	xcomp	_	_
11	terminally	terminally	RB	RB	_	10	advmod	_	_
12	into	into	IN	IN	_	14	case	_	_
13	mature	mature	JJ	JJ	_	14	amod	_	_
14	granulocytes	granulocyte	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	subsequently	subsequently	RB	RB	_	18	advmod	_	_
18	die	die	VBP	VBP	_	14	acl:relcl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	apoptosis	apoptosis	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biological	biological	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	RA	ra	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	families	family	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	:	:	:	:	_	11	punct	_	_
16	retinoic	retinoic	JJ	JJ	_	18	amod	_	_
17	acid	acid	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	11	dep	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	RARs	rar	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	retinoid	retinoid	NN	NN	_	25	compound	_	_
24	X	x	NN	NN	_	25	compound	_	_
25	receptors	receptor	NNS	NNS	_	18	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	RXRs	rxr	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	7	punct	_	_

1	RARs	rar	NNS	NNS	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	RXRs	rxr	NNS	NNS	_	1	conj	_	_
4	form	form	NN	NN	_	0	root	_	_
5	heterodimers	heterodimer	NNS	NNS	_	4	dobj	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	regulate	regulate	VBP	VBP	_	4	conj	_	_
8	retinoid-mediated	retinoid-mediated	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	developed	develop	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	RAR-selective	rar-selective	JJ	JJ	_	8	amod	_	_
8	antagonist	antagonist	NN	NN	_	4	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ER27191	er27191	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	prevents	prevent	VBZ	VBZ	_	8	acl:relcl	_	_
14	RAR	rar	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	retinoids	retinoid	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	13	advcl	_	_
2	this	this	DT	DT	_	4	det	_	_
3	RAR-selective	rar-selective	JJ	JJ	_	4	amod	_	_
4	antagonist	antagonist	NN	NN	_	1	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	RXR	rxr	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	RAR	rar	NN	NN	_	7	conj	_	_
10	agonist	agonist	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
14	the	the	DT	DT	_	17	det	_	_
15	RAR-mediated	rar-mediated	JJ	JJ	_	17	amod	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	important	important	JJ	JJ	_	13	ccomp	_	_
20	for	for	IN	IN	_	21	case	_	_
21	differentiation	differentiation	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	apoptosis	apoptosis	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	myeloid	myeloid	JJ	JJ	_	27	amod	_	_
26	leukemic	leukemic	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	Simple	simple	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RXRs	rxr	NNS	NNS	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	sufficient	sufficient	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	combination	combination	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	RAR-selective	rar-selective	JJ	JJ	_	8	amod	_	_
8	antagonist	antagonist	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	9-cis	9-cis	JJ	JJ	_	11	amod	_	_
11	RA	ra	NN	NN	_	8	conj	_	_
12	resulted	result	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	partial	partial	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	apoptosis	apoptosis	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	HL-60	hl-60	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	NB4	nb4	NN	NN	_	19	conj	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	,	,	,	,	_	12	punct	_	_
24	whereas	whereas	IN	IN	_	12	dep	_	_
25	the	the	DT	DT	_	27	det	_	_
26	RAR	rar	NN	NN	_	27	compound	_	_
27	antagonist	antagonist	NN	NN	_	29	nsubj	_	_
28	completely	completely	RB	RB	_	29	advmod	_	_
29	blocked	block	VBD	VBD	_	12	parataxis	_	_
30	all-trans	all-trans	JJ	JJ	_	31	amod	_	_
31	RA-induced	ra-induced	JJ	JJ	_	32	amod	_	_
32	differentiation	differentiation	NN	NN	_	29	dobj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	apoptosis	apoptosis	NN	NN	_	32	conj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	12	punct	_	_

1	Additional	additional	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	levels	level	NNS	NNS	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	BCL-2	bcl-2	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	decreased	decrease	VBD	VBD	_	3	ccomp	_	_
10	during	during	IN	IN	_	11	case	_	_
11	differentiation	differentiation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
14	leukemic	leukemic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	HL-60	hl-60	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	11	nsubj	_	_
5	transduced	transduce	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	bcl-2	bcl-2	NN	NN	_	10	compound	_	_
9	expression	expression	NN	NN	_	10	compound	_	_
10	vector	vector	NN	NN	_	5	nmod	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	15	det	_	_
13	same	same	JJ	JJ	_	15	amod	_	_
14	differentiation	differentiation	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	11	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	retinoids	retinoid	NNS	NNS	_	15	nmod	_	_
18	as	as	IN	IN	_	19	dep	_	_
19	did	do	VBD	VBD	_	11	advcl	_	_
20	parental	parental	JJ	JJ	_	22	amod	_	_
21	HL-60	hl-60	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nsubj	_	_
23	even	even	RB	RB	_	27	advmod	_	_
24	though	though	IN	IN	_	27	mark	_	_
25	apoptosis	apoptosis	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	inhibited	inhibit	VBN	VBN	_	11	advcl	_	_
28	in	in	IN	IN	_	31	case	_	_
29	these	these	DT	DT	_	31	det	_	_
30	bcl-2-transduced	bcl-2-transduced	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	,	,	,	,	_	11	punct	_	_
33	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
34	that	that	IN	IN	_	39	mark	_	_
35	differentiation	differentiation	NN	NN	_	39	nsubjpass	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	apoptosis	apoptosis	NN	NN	_	35	conj	_	_
38	are	be	VBP	VBP	_	39	auxpass	_	_
39	regulated	regulate	VBN	VBN	_	33	ccomp	_	_
40	independently	independently	RB	RB	_	39	advmod	_	_
41	in	in	IN	IN	_	44	case	_	_
42	myeloid	myeloid	JJ	JJ	_	44	amod	_	_
43	leukemic	leukemic	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	39	nmod	_	_
45	.	.	.	.	_	11	punct	_	_

1	Fibrinogen	fibrinogen	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	phagocytes	phagocyte	NNS	NNS	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Adhesion	adhesion	NN	NN	_	6	nsubjpass	_	_
2	to	to	TO	TO	_	4	case	_	_
3	extracellular	extracellular	JJ	JJ	_	4	amod	_	_
4	matrices	matrix	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	modulate	modulate	VB	VB	_	6	xcomp	_	_
9	leukocyte	leukocyte	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	although	although	IN	IN	_	18	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	mechanisms	mechanism	NNS	NNS	_	18	nsubjpass	_	_
15	are	be	VBP	VBP	_	18	auxpass	_	_
16	not	not	RB	RB	_	18	neg	_	_
17	fully	fully	RB	RB	_	18	advmod	_	_
18	understood	understand	VBN	VBN	_	6	advcl	_	_
19	.	.	.	.	_	6	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	phagocytes	phagocyte	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	exposed	expose	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	fibrinous	fibrinous	JJ	JJ	_	8	amod	_	_
7	provisional	provisional	JJ	JJ	_	8	amod	_	_
8	matrix	matrix	NN	NN	_	4	nmod	_	_
9	throughout	throughout	IN	IN	_	10	case	_	_
10	migration	migration	NN	NN	_	4	nmod	_	_
11	into	into	IN	IN	_	13	case	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	foci	focus	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	so	so	RB	RB	_	4	advmod	_	_
16	this	this	DT	DT	_	17	det	_	_
17	study	study	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	undertaken	undertake	VBN	VBN	_	4	parataxis	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	determine	determine	VB	VB	_	19	xcomp	_	_
22	whether	whether	IN	IN	_	24	mark	_	_
23	fibrinogen	fibrinogen	NN	NN	_	24	nsubj	_	_
24	triggers	trigger	VBZ	VBZ	_	21	ccomp	_	_
25	activation	activation	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
28	B	b	NN	NN	_	30	compound	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	U937	u937	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
3	differentiated	differentiate	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	5	case	_	_
5	PMA	pma	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	nonadherent	nonadherent	JJ	JJ	_	8	amod	_	_
8	culture	culture	NN	NN	_	3	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	express	express	VB	VB	_	10	xcomp	_	_
13	two	two	CD	CD	_	15	nummod	_	_
14	fibrinogen-binding	fibrinogen-binding	JJ	JJ	_	15	amod	_	_
15	integrins	integrin	NNS	NNS	_	12	dobj	_	_
16	,	,	,	,	_	12	punct	_	_
17	predominately	predominately	RB	RB	_	18	advmod	_	_
18	CD11b/CD18	cd11b/cd18	NN	NN	_	12	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	to	to	TO	TO	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	lesser	lesser	JJR	JJR	_	24	amod	_	_
24	extent	extent	NN	NN	_	26	nmod	_	_
25	,	,	,	,	_	26	punct	_	_
26	CD11c/CD18	cd11c/cd18	NN	NN	_	18	conj	_	_
27	.	.	.	.	_	10	punct	_	_

1	Cells	cell	NNS	NNS	_	18	nsubjpass	_	_
2	stimulated	stimulate	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	4	case	_	_
4	fibrinogen	fibrinogen	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	10-100	10-100	CD	CD	_	7	nummod	_	_
7	microg/ml	microg/ml	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	/Mn2+	/mn2+	JJ	JJ	_	4	amod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	50	50	CD	CD	_	12	nummod	_	_
12	microM	microm	NN	NN	_	4	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	for	for	IN	IN	_	16	case	_	_
15	2	2	CD	CD	_	16	nummod	_	_
16	h	h	NN	NN	_	2	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	examined	examine	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	23	case	_	_
20	electrophoretic	electrophoretic	JJ	JJ	_	23	amod	_	_
21	mobility	mobility	NN	NN	_	23	compound	_	_
22	shift	shift	NN	NN	_	23	compound	_	_
23	assay	assay	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	18	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	12	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	minimal	minimal	JJ	JJ	_	3	amod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	unstimulated	unstimulated	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	substantially	substantially	RB	RB	_	12	advmod	_	_
12	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	fibrinogen	fibrinogen	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	Fibrinogen	fibrinogen	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	caused	cause	VBD	VBD	_	0	root	_	_
4	activation	activation	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AP-1	ap-1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	6	cc	_	_
10	SP1	sp1	NN	NN	_	6	conj	_	_
11	or	or	CC	CC	_	6	cc	_	_
12	cAMP	camp	NN	NN	_	19	compound	_	_
13	response	response	NN	NN	_	19	compound	_	_
14	element-binding	element-binding	JJ	JJ	_	19	amod	_	_
15	protein	protein	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	CREB	creb	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	factors	factor	NNS	NNS	_	6	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Blocking	blocking	NN	NN	_	7	csubj	_	_
2	mAbs	mab	NNS	NNS	_	1	dobj	_	_
3	against	against	IN	IN	_	4	case	_	_
4	CD18	cd18	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	CD11b	cd11b	NN	NN	_	4	conj	_	_
7	abrogated	abrogate	VBD	VBD	_	0	root	_	_
8	fibrinogen-induced	fibrinogen-induced	JJ	JJ	_	11	amod	_	_
9	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	12	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	U937	u937	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	transfected	transfect	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	plasmid	plasmid	NN	NN	_	12	nmod	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
19	enhancer	enhancer	NN	NN	_	16	dobj	_	_
20	(	(	-LRB-	-LRB-	_	19	punct	_	_
21	bearing	bear	VBG	VBG	_	19	acl	_	_
22	two	two	CD	CD	_	25	nummod	_	_
23	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	sites	site	NNS	NNS	_	21	dobj	_	_
26	)	)	-RRB-	-RRB-	_	19	punct	_	_
27	coupled	couple	VBN	VBN	_	19	acl	_	_
28	to	to	TO	TO	_	35	case	_	_
29	a	a	DT	DT	_	35	det	_	_
30	chloramphenicol	chloramphenicol	NN	NN	_	35	compound	_	_
31	acetyltransferase	acetyltransferase	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	CAT	cat	NN	NN	_	35	compound	_	_
34	)	)	-RRB-	-RRB-	_	35	punct	_	_
35	reporter	reporter	NN	NN	_	27	nmod	_	_
36	.	.	.	.	_	12	punct	_	_

1	Cells	cell	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	subsequently	subsequently	RB	RB	_	4	advmod	_	_
4	stimulated	stimulate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	1	1	LS	LS	_	8	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	PMA	pma	NN	NN	_	4	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	24	24	CD	CD	_	11	nummod	_	_
11	h	h	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	inducing	induce	VBG	VBG	_	15	dep	_	_
14	CAT	cat	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	4	xcomp	_	_
16	by	by	IN	IN	_	17	case	_	_
17	2.6-fold	2.6-fold	JJ	JJ	_	15	dep	_	_
18	,	,	,	,	_	4	punct	_	_
19	2	2	LS	LS	_	21	dep	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	fibrinogen/Mn2+	fibrinogen/mn2+	NN	NN	_	4	conj	_	_
22	for	for	IN	IN	_	24	case	_	_
23	2	2	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	inducing	induce	VBG	VBG	_	28	dep	_	_
27	CAT	cat	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	21	xcomp	_	_
29	by	by	IN	IN	_	30	case	_	_
30	3.2-fold	3.2-fold	JJ	JJ	_	28	dep	_	_
31	,	,	,	,	_	4	punct	_	_
32	or	or	CC	CC	_	4	cc	_	_
33	3	3	LS	LS	_	35	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	costimulation	costimulation	NN	NN	_	4	conj	_	_
36	with	with	IN	IN	_	37	case	_	_
37	fibrinogen	fibrinogen	NN	NN	_	35	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	PMA	pma	NN	NN	_	37	conj	_	_
40	,	,	,	,	_	35	punct	_	_
41	inducing	induce	VBG	VBG	_	35	advcl	_	_
42	5.7-fold	5.7-fold	JJ	JJ	_	41	advmod	_	_
43	the	the	DT	DT	_	45	det	_	_
44	CAT	cat	NN	NN	_	45	compound	_	_
45	activity	activity	NN	NN	_	41	dobj	_	_
46	induced	induce	VBN	VBN	_	45	acl	_	_
47	by	by	IN	IN	_	48	case	_	_
48	PMA	pma	NN	NN	_	46	nmod	_	_
49	alone	alone	RB	RB	_	48	advmod	_	_
50	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	contact	contact	NN	NN	_	9	nsubj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	fibrinogen-derived	fibrinogen-derived	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	4	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	contribute	contribute	VB	VB	_	2	ccomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
12	phagocyte	phagocyte	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	signaling	signaling	NN	NN	_	9	nmod	_	_
16	through	through	IN	IN	_	17	case	_	_
17	CD11b/CD18	cd11b/cd18	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	resulting	result	VBG	VBG	_	9	xcomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	selective	selective	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	factors	factor	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	including	include	VBG	VBG	_	30	case	_	_
29	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	Ex	ex	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	tumor-draining	tumor-draining	JJ	JJ	_	9	amod	_	_
6	lymph	lymph	NN	NN	_	9	compound	_	_
7	node	node	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	reverses	reverse	VBZ	VBZ	_	0	root	_	_
11	defects	defect	VBZ	VBZ	_	10	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	signal	signal	NN	NN	_	15	compound	_	_
14	transduction	transduction	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	adoptive	adoptive	JJ	JJ	_	3	amod	_	_
3	transfer	transfer	NN	NN	_	24	nsubj	_	_
4	of	of	IN	IN	_	12	case	_	_
5	tumor-draining	tumor-draining	JJ	JJ	_	12	amod	_	_
6	lymph	lymph	NN	NN	_	7	compound	_	_
7	node	node	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	LN	ln	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	nmod	_	_
13	activated	activate	VBD	VBD	_	12	acl	_	_
14	ex	ex	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	anti-CD3	anti-cd3	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	interleukin	interleukin	NN	NN	_	17	conj	_	_
20	2	2	CD	CD	_	19	nummod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IL-2	il-2	NN	NN	_	19	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	mediates	mediate	VBZ	VBZ	_	0	root	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regression	regression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	33	case	_	_
28	the	the	DT	DT	_	33	det	_	_
29	poorly	poorly	RB	RB	_	30	advmod	_	_
30	immunogenic	immunogenic	JJ	JJ	_	33	amod	_	_
31	murine	murine	JJ	JJ	_	33	amod	_	_
32	melanoma	melanoma	NN	NN	_	33	compound	_	_
33	D5	d5	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	efficacy	efficacy	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	activated	activate	VBN	VBN	_	7	amod	_	_
6	LN	ln	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	augmented	augment	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	18	advmod	_	_
11	the	the	DT	DT	_	13	det	_	_
12	sensitizing	sensitize	VBG	VBG	_	13	amod	_	_
13	tumor	tumor	NN	NN	_	18	nsubj	_	_
14	is	be	VBZ	VBZ	_	18	cop	_	_
15	a	a	DT	DT	_	18	det	_	_
16	genetically	genetically	RB	RB	_	17	advmod	_	_
17	modified	modify	VBN	VBN	_	18	amod	_	_
18	variant	variant	NN	NN	_	9	advcl	_	_
19	(	(	-LRB-	-LRB-	_	18	punct	_	_
20	designated	designate	VBN	VBN	_	18	acl	_	_
21	D5G6	d5g6	NN	NN	_	20	xcomp	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	secretes	secrete	VBZ	VBZ	_	18	acl:relcl	_	_
25	granulocyte/macrophage-colony-stimulating	granulocyte/macrophage-colony-stimulating	JJ	JJ	_	26	amod	_	_
26	factor	factor	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	contrast	contrast	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	anti-CD3/IL-2-activated	anti-cd3/il-2-activated	JJ	JJ	_	6	amod	_	_
5	LN	ln	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	adoptive	adoptive	JJ	JJ	_	9	amod	_	_
9	transfer	transfer	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	freshly	freshly	RB	RB	_	12	advmod	_	_
12	isolated	isolate	VBN	VBN	_	16	amod	_	_
13	tumor-draining	tumor-draining	JJ	JJ	_	16	amod	_	_
14	LN	ln	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	has	have	VBZ	VBZ	_	0	root	_	_
18	no	no	DT	DT	_	20	neg	_	_
19	therapeutic	therapeutic	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	36	advcl	_	_
3	whether	whether	IN	IN	_	14	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	acquisition	acquisition	NN	NN	_	14	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	antitumor	antitumor	JJ	JJ	_	8	amod	_	_
8	function	function	NN	NN	_	5	nmod	_	_
9	during	during	IN	IN	_	12	case	_	_
10	ex	ex	FW	FW	_	12	amod	_	_
11	vivo	vivo	FW	FW	_	10	dep	_	_
12	activation	activation	NN	NN	_	5	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	2	ccomp	_	_
15	with	with	IN	IN	_	16	case	_	_
16	modifications	modification	NNS	NNS	_	14	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	signal	signal	NN	NN	_	20	compound	_	_
19	transduction	transduction	NN	NN	_	20	compound	_	_
20	capacity	capacity	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	36	punct	_	_
22	the	the	DT	DT	_	25	det	_	_
23	protein	protein	NN	NN	_	25	compound	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	kinases	kinase	NNS	NNS	_	36	nsubjpass	_	_
26	p56lck	p56lck	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	p59fyn	p59fyn	NN	NN	_	26	conj	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	proteins	protein	NNS	NNS	_	25	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
34	family	family	NN	NN	_	30	nmod	_	_
35	were	be	VBD	VBD	_	36	auxpass	_	_
36	analyzed	analyze	VBN	VBN	_	0	root	_	_
37	in	in	IN	IN	_	41	case	_	_
38	tumor-draining	tumor-draining	JJ	JJ	_	41	amod	_	_
39	LN	ln	NN	NN	_	41	compound	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	36	nmod	_	_
42	.	.	.	.	_	36	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p56lck	p56lck	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p59fyn	p59fyn	NN	NN	_	4	conj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	lower	lower	JJR	JJR	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	tumor-draining	tumor-draining	JJ	JJ	_	8	nmod	_	_
11	than	than	IN	IN	_	16	case	_	_
12	in	in	IN	IN	_	16	case	_	_
13	normal	normal	JJ	JJ	_	16	amod	_	_
14	LN	ln	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	8	advcl	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	production	production	NN	NN	_	24	nsubjpass	_	_
19	of	of	IN	IN	_	21	case	_	_
20	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	21	amod	_	_
21	substrates	substrate	NNS	NNS	_	18	nmod	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	markedly	markedly	RB	RB	_	24	advmod	_	_
24	depressed	depress	VBN	VBN	_	8	conj	_	_
25	following	follow	VBG	VBG	_	27	case	_	_
26	anti-CD3	anti-cd3	JJ	JJ	_	27	amod	_	_
27	stimulation	stimulation	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	5-day	5-day	JJ	JJ	_	4	amod	_	_
3	anti-CD3/IL-2	anti-cd3/il-2	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	16	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	levels	level	NNS	NNS	_	16	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p56lck	p56lck	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	p59fyn	p59fyn	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	protein	protein	NN	NN	_	15	compound	_	_
13	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	8	conj	_	_
16	increased	increase	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Interestingly	interestingly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	levels	level	NNS	NNS	_	15	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	p56lck	p56lck	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	p59fyn	p59fyn	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	6	conj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	higher	higher	JJR	JJR	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	activated	activate	VBN	VBN	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	derived	derive	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	22	case	_	_
22	LN	ln	NN	NN	_	20	nmod	_	_
23	that	that	IN	IN	_	24	nsubj	_	_
24	drained	drain	VBD	VBD	_	22	acl:relcl	_	_
25	D5G6	d5g6	NN	NN	_	24	dobj	_	_
26	than	than	IN	IN	_	30	mark	_	_
27	they	they	PRP	PRP	_	30	nsubj	_	_
28	were	be	VBD	VBD	_	30	cop	_	_
29	in	in	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	15	advcl	_	_
31	from	from	IN	IN	_	33	case	_	_
32	D5	d5	NN	NN	_	33	compound	_	_
33	tumors	tumor	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	cytoplasmic	cytoplasmic	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	c-Rel	c-rel	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Rel	rel	NN	NN	_	11	compound	_	_
11	A	a	NN	NN	_	8	conj	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	normal	normal	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	freshly	freshly	RB	RB	_	16	advmod	_	_
16	isolated	isolate	VBN	VBN	_	18	amod	_	_
17	tumor-draining	tumor-draining	JJ	JJ	_	18	amod	_	_
18	LN	ln	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	as	as	IN	IN	_	25	dep	_	_
21	was	be	VBD	VBD	_	25	dep	_	_
22	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
23	kappaB	kappab	NN	NN	_	25	compound	_	_
24	DNA-binding	dna-binding	JJ	JJ	_	25	amod	_	_
25	activity	activity	NN	NN	_	13	advcl	_	_
26	induced	induce	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	anti-CD3	anti-cd3	JJ	JJ	_	29	amod	_	_
29	mAb	mab	NN	NN	_	26	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	phorbol	phorbol	NN	NN	_	33	compound	_	_
32	myristate	myristate	NN	NN	_	33	compound	_	_
33	acetate	acetate	NN	NN	_	29	conj	_	_
34	.	.	.	.	_	13	punct	_	_

1	Stimulation	stimulation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	activated	activate	VBN	VBN	_	5	amod	_	_
4	LN	ln	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	D5	d5	NN	NN	_	9	compound	_	_
8	tumor	tumor	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	induced	induce	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	translocation	translocation	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	26	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	recovery	recovery	NN	NN	_	26	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	proteins	protein	NNS	NNS	_	6	nmod	_	_
9	mediating	mediate	VBG	VBG	_	8	acl	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	9	dobj	_	_
12	through	through	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	T	t	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	receptor/CD3	receptor/cd3	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	9	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	LN	ln	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	activated	activate	VBD	VBD	_	21	acl	_	_
23	ex	ex	FW	FW	_	24	compound	_	_
24	vivo	vivo	FW	FW	_	22	advmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	associated	associate	VBN	VBN	_	3	ccomp	_	_
27	with	with	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	acquisition	acquisition	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	antitumor	antitumor	JJ	JJ	_	32	amod	_	_
32	function	function	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	gamma-IFN	gamma-ifn	NN	NN	_	5	compound	_	_
4	responsive	responsive	JJ	JJ	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	scavenger	scavenger	NN	NN	_	10	compound	_	_
8	receptor	receptor	NN	NN	_	10	compound	_	_
9	over-expressing	over-expressing	NN	NN	_	10	compound	_	_
10	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	xanthomatosis	xanthomatosis	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	described	describe	VBN	VBN	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	inherited	inherit	VBN	VBN	_	7	amod	_	_
7	over-expression	over-expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	macrophage	macrophage	NN	NN	_	7	nmod	_	_
11	scavenger	scavenger	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	10	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SR	sr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	in	in	IN	IN	_	18	case	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	members	member	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	kindred	kindred	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	only	only	RB	RB	_	26	advmod	_	_
26	two	two	CD	CD	_	29	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	whom	whom	WP	WP	_	26	nmod	_	_
29	displayed	display	VBD	VBD	_	20	acl:relcl	_	_
30	extensive	extensive	JJ	JJ	_	31	amod	_	_
31	xanthomatosis	xanthomatosis	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	6	dep	_	_
2	mRNA	mrna	NN	NN	_	4	compound	_	_
3	differential	differential	JJ	JJ	_	4	amod	_	_
4	display	display	NN	NN	_	1	dobj	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	abnormally	abnormally	RB	RB	_	8	advmod	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	signal	signal	NN	NN	_	13	compound	_	_
13	transducer	transducer	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	activator	activator	NN	NN	_	17	compound	_	_
16	of	of	IN	IN	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	13	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	STAT1alpha	stat1alpha	NN	NN	_	13	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
23	from	from	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	proband	proband	NN	NN	_	26	compound	_	_
26	II-2	ii-2	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	23	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	gamma-interferon	gamma-interferon	NN	NN	_	5	compound	_	_
4	inducible	inducible	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	10	10	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IP-10	ip-10	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	5	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	STAT1alpha-responsive	stat1alpha-responsive	JJ	JJ	_	13	amod	_	_
13	gene	gene	NN	NN	_	5	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	mediator	mediator	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	5	punct	_	_
20	was	be	VBD	VBD	_	23	auxpass	_	_
21	also	also	RB	RB	_	23	advmod	_	_
22	abnormally	abnormally	RB	RB	_	23	advmod	_	_
23	expressed	express	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
27	from	from	IN	IN	_	28	case	_	_
28	II-2	ii-2	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	23	punct	_	_

1	Over-expression	over-expression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	both	both	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	restricted	restricted	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	II-2	ii-2	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	observed	observe	VBN	VBN	_	6	conj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
17	from	from	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	clinically	clinically	RB	RB	_	20	advmod	_	_
20	unaffected	unaffected	JJ	JJ	_	22	amod	_	_
21	family	family	NN	NN	_	22	compound	_	_
22	members	member	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	unlike	unlike	IN	IN	_	25	case	_	_
25	that	that	DT	DT	_	6	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	SR	sr	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	retardation	retardation	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	8	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	THP-1	thp-1	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	extracts	extract	NNS	NNS	_	3	nmod	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	gamma-IFN	gamma-ifn	NN	NN	_	10	nmod:npmod	_	_
10	inducible	inducible	JJ	JJ	_	13	amod	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	dobj	_	_
14	to	to	TO	TO	_	20	case	_	_
15	three	three	CD	CD	_	20	nummod	_	_
16	potential	potential	JJ	JJ	_	20	amod	_	_
17	STATI	stati	NN	NN	_	20	compound	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	13	nmod	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	human	human	JJ	JJ	_	26	amod	_	_
24	IP-10	ip-10	NN	NN	_	26	compound	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	region	region	NN	NN	_	8	nmod	_	_
27	from	from	IN	IN	_	28	case	_	_
28	nucleotides	nucleotide	NNS	NNS	_	26	nmod	_	_
29	-245	-245	CD	CD	_	28	nummod	_	_
30	to	to	TO	TO	_	28	dep	_	_
31	-188	-188	CD	CD	_	28	nummod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Taken	take	VBN	VBN	_	5	dep	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	gamma-interferon	gamma-interferon	NN	NN	_	10	amod	_	_
8	mediated	mediate	VBD	VBD	_	7	dep	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	responsible	responsible	JJ	JJ	_	5	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	STAT1alpha-induced	stat1alpha-induced	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IP-10	ip-10	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	THP-1	thp-1	NN	NN	_	22	compound	_	_
22	macrophages	macrophage	NNS	NNS	_	12	nmod	_	_
23	as	as	RB	RB	_	22	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	in	in	IN	IN	_	27	case	_	_
27	monocytes	monocyte	NNS	NNS	_	22	conj	_	_
28	from	from	IN	IN	_	29	case	_	_
29	II-2	ii-2	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
4	from	from	IN	IN	_	10	case	_	_
5	familial	familial	JJ	JJ	_	6	amod	_	_
6	hypercholesterolemic	hypercholesterolemic	JJ	JJ	_	10	amod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	FH	fh	NN	NN	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	subjects	subject	NNS	NNS	_	3	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	who	who	WP	WP	_	14	nsubj	_	_
13	frequently	frequently	RB	RB	_	14	advmod	_	_
14	develop	develop	VBP	VBP	_	10	acl:relcl	_	_
15	xanthomatosis	xanthomatosis	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	10	punct	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	significant	significant	JJ	JJ	_	20	amod	_	_
20	number	number	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	subjects	subject	NNS	NNS	_	20	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	elevated	elevated	JJ	JJ	_	25	amod	_	_
25	STAT1alpha	stat1alpha	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IP-10	ip-10	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	17	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	12	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	gamma-IFN	gamma-ifn	NN	NN	_	10	compound	_	_
10	signaling	signaling	NN	NN	_	7	nmod	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	play	play	VB	VB	_	3	ccomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	foam	foam	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	formation	formation	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	xanthomatosis	xanthomatosis	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Targeted	targeted	JJ	JJ	_	2	amod	_	_
2	disruption	disruption	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	MyD88	myd88	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	results	result	VBZ	VBZ	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	loss	loss	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	IL-1-	il-1-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-18-mediated	il-18-mediated	JJ	JJ	_	11	conj	_	_
14	function	function	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	MyD88	myd88	NN	NN	_	14	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	originally	originally	RB	RB	_	4	advmod	_	_
4	isolated	isolate	VBN	VBN	_	1	acl	_	_
5	as	as	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
8	differentiation	differentiation	NN	NN	_	11	compound	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	response	response	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	act	act	VB	VB	_	14	xcomp	_	_
17	as	as	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	adaptor	adaptor	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	25	case	_	_
21	interleukin-1	interleukin-1	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	IL-1	il-1	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	signaling	signaling	NN	NN	_	16	nmod	_	_
26	by	by	IN	IN	_	27	mark	_	_
27	interacting	interact	VBG	VBG	_	16	advcl	_	_
28	with	with	IN	IN	_	33	case	_	_
29	both	both	CC	CC	_	33	cc:preconj	_	_
30	the	the	DT	DT	_	33	det	_	_
31	IL-1	il-1	NN	NN	_	33	compound	_	_
32	receptor	receptor	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	27	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	IL-1	il-1	NN	NN	_	37	compound	_	_
36	receptor-associated	receptor-associated	JJ	JJ	_	37	amod	_	_
37	kinase	kinase	NN	NN	_	33	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	IRAK	irak	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	14	punct	_	_

1	Mice	mouse	NNS	NNS	_	9	nsubj	_	_
2	generated	generate	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	4	case	_	_
4	gene	gene	NN	NN	_	2	nmod	_	_
5	targeting	targeting	NN	NN	_	4	dep	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	lack	lack	VB	VB	_	5	xcomp	_	_
8	MyD88	myd88	NN	NN	_	7	dobj	_	_
9	have	have	VBP	VBP	_	0	root	_	_
10	defects	defect	VBZ	VBZ	_	9	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	proliferation	proliferation	NN	NN	_	9	nmod	_	_
15	as	as	RB	RB	_	14	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	induction	induction	NN	NN	_	14	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	acute	acute	JJ	JJ	_	21	amod	_	_
21	phase	phase	NN	NN	_	18	nmod	_	_
22	proteins	protein	NNS	NNS	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	cytokines	cytokine	NNS	NNS	_	22	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	response	response	NN	NN	_	28	dep	_	_
27	to	to	TO	TO	_	28	case	_	_
28	IL-1	il-1	NN	NN	_	14	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	Increases	increase	NNS	NNS	_	15	nsubjpass	_	_
2	in	in	IN	IN	_	4	case	_	_
3	interferon-gamma	interferon-gamma	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	natural	natural	JJ	JJ	_	9	amod	_	_
7	killer	killer	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	response	response	NN	NN	_	13	dep	_	_
12	to	to	TO	TO	_	13	case	_	_
13	IL-18	il-18	NN	NN	_	1	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	abrogated	abrogate	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	Th1	th1	NN	NN	_	4	compound	_	_
4	response	response	NN	NN	_	7	nsubj	_	_
5	is	be	VBZ	VBZ	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	impaired	impaired	JJ	JJ	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	IL-18-induced	il-18-induced	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	15	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-Jun	c-jun	NN	NN	_	10	compound	_	_
9	N-terminal	n-terminal	JJ	JJ	_	10	amod	_	_
10	kinase	kinase	NN	NN	_	6	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	JNK	jnk	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	blocked	block	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	MyD88-/-	myd88-/-	JJ	JJ	_	19	amod	_	_
18	Th1-developing	th1-developing	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	MyD88	myd88	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	critical	critical	JJ	JJ	_	12	amod	_	_
12	component	component	NN	NN	_	6	ccomp	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	cascade	cascade	NN	NN	_	12	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	mediated	mediate	VBN	VBN	_	12	dep	_	_
20	by	by	IN	IN	_	22	case	_	_
21	IL-1	il-1	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	19	nmod	_	_
23	as	as	RB	RB	_	22	cc	_	_
24	well	well	RB	RB	_	23	mwe	_	_
25	as	as	IN	IN	_	23	mwe	_	_
26	IL-18	il-18	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	22	conj	_	_
28	.	.	.	.	_	6	punct	_	_

1	Changes	change	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	4	case	_	_
3	PKC	pkc	NN	NN	_	4	compound	_	_
4	isoforms	isoform	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	alveolar	alveolar	JJ	JJ	_	8	amod	_	_
8	macrophages	macrophage	NNS	NNS	_	1	nmod	_	_
9	compared	compare	VBN	VBN	_	12	case	_	_
10	with	with	IN	IN	_	12	case	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Alveolar	alveolar	JJ	JJ	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	3	nsubj	_	_
3	play	play	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	host	host	NN	NN	_	9	compound	_	_
9	defense	defense	NN	NN	_	3	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	in	in	IN	IN	_	13	case	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	types	type	NNS	NNS	_	9	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	processes	process	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	lung	lung	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	exhibit	exhibit	VBP	VBP	_	0	root	_	_
4	many	many	JJ	JJ	_	5	amod	_	_
5	alterations	alteration	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	function	function	NN	NN	_	5	nmod	_	_
8	compared	compare	VBN	VBN	_	12	case	_	_
9	with	with	IN	IN	_	12	case	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	precursor	precursor	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	3	advcl	_	_
13	,	,	,	,	_	12	punct	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	monocytes	monocyte	NNS	NNS	_	12	appos	_	_
16	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	13	advcl	_	_
3	a	a	DT	DT	_	5	det	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	2	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	differences	difference	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	function	function	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	evaluated	evaluate	VBD	VBD	_	0	root	_	_
14	expression	expression	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	22	case	_	_
16	protein	protein	NN	NN	_	22	compound	_	_
17	kinase	kinase	NN	NN	_	22	compound	_	_
18	C	c	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	PKC	pkc	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	isoforms	isoform	NNS	NNS	_	14	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	Ca2+-dependent	ca2+-dependent	JJ	JJ	_	8	amod	_	_
7	PKC	pkc	NN	NN	_	8	compound	_	_
8	isoforms	isoform	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
11	compared	compare	VBN	VBN	_	14	case	_	_
12	with	with	IN	IN	_	14	case	_	_
13	alveolar	alveolar	JJ	JJ	_	14	amod	_	_
14	macrophages	macrophage	NNS	NNS	_	4	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Ca2+-independent	ca2+-independent	JJ	JJ	_	9	amod	_	_
9	isoforms	isoform	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	alveolar	alveolar	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
13	compared	compare	VBN	VBN	_	15	case	_	_
14	with	with	IN	IN	_	15	case	_	_
15	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	consequence	consequence	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PKC	pkc	NN	NN	_	5	nmod	_	_
8	can	can	MD	MD	_	11	aux	_	_
9	be	be	VB	VB	_	11	cop	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	expression	expression	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	19	case	_	_
13	mitogen-activated	mitogen-activated	JJ	JJ	_	19	amod	_	_
14	protein	protein	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	MAP	map	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	pathways	pathway	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Therefore	therefore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	evaluated	evaluate	VBD	VBD	_	0	root	_	_
6	activation	activation	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	MAP	map	NN	NN	_	15	compound	_	_
10	kinase	kinase	NN	NN	_	15	compound	_	_
11	extracellular	extracellular	JJ	JJ	_	15	amod	_	_
12	signal-regulated	signal-regulated	JJ	JJ	_	15	amod	_	_
13	kinase	kinase	NN	NN	_	15	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	ERK	erk	NN	NN	_	6	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	2	2	CD	CD	_	15	nummod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	phorbol	phorbol	NN	NN	_	21	compound	_	_
21	ester	ester	NN	NN	_	6	nmod	_	_
22	phorbol	phorbol	NN	NN	_	24	compound	_	_
23	12-myristate	12-myristate	NN	NN	_	24	compound	_	_
24	13-acetate	13-acetate	NN	NN	_	21	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	PMA	pma	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	5	punct	_	_

1	PMA	pma	NN	NN	_	2	nsubj	_	_
2	activated	activated	JJ	JJ	_	0	root	_	_
3	ERK2	erk2	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	alveolar	alveolar	JJ	JJ	_	8	amod	_	_
8	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	monocytes	monocyte	NNS	NNS	_	8	conj	_	_
11	;	;	:	:	_	2	punct	_	_
12	however	however	RB	RB	_	2	advmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	monocytes	monocyte	NNS	NNS	_	16	nsubj	_	_
15	consistently	consistently	RB	RB	_	16	advmod	_	_
16	showed	show	VBD	VBD	_	2	dep	_	_
17	a	a	DT	DT	_	20	det	_	_
18	significantly	significantly	RB	RB	_	19	advmod	_	_
19	greater	greater	JJR	JJR	_	20	amod	_	_
20	activation	activation	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	ERK2	erk2	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	20	nmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	PMA	pma	NN	NN	_	20	nmod	_	_
26	compared	compare	VBN	VBN	_	29	case	_	_
27	with	with	IN	IN	_	29	case	_	_
28	alveolar	alveolar	JJ	JJ	_	29	amod	_	_
29	macrophages	macrophage	NNS	NNS	_	20	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Another	another	DT	DT	_	3	det	_	_
2	known	known	JJ	JJ	_	3	amod	_	_
3	consequence	consequence	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PKC	pkc	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	subsequent	subsequent	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	6	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	ERK	erk	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	activation	activation	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	transcription	transcription	NN	NN	_	22	compound	_	_
20	factor	factor	NN	NN	_	22	compound	_	_
21	activator	activator	NN	NN	_	22	compound	_	_
22	protein-1	protein-1	NN	NN	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	AP-1	ap-1	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AP-1	ap-1	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	PMA	pma	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	macrophages	macrophage	NNS	NNS	_	11	conj	_	_
14	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	very	very	RB	RB	_	4	advmod	_	_
4	little	little	JJ	JJ	_	6	amod	_	_
5	detectable	detectable	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	AP-1	ap-1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	2	punct	_	_
10	as	as	IN	IN	_	11	mark	_	_
11	assessed	assess	VBN	VBN	_	2	advcl	_	_
12	in	in	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	gel	gel	NN	NN	_	16	compound	_	_
15	shift	shift	NN	NN	_	16	compound	_	_
16	assay	assay	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	alveolar	alveolar	JJ	JJ	_	20	amod	_	_
20	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
21	,	,	,	,	_	2	punct	_	_
22	whereas	whereas	IN	IN	_	2	dep	_	_
23	monocytes	monocyte	NNS	NNS	_	24	nsubj	_	_
24	showed	show	VBD	VBD	_	2	parataxis	_	_
25	a	a	DT	DT	_	27	det	_	_
26	substantial	substantial	JJ	JJ	_	27	amod	_	_
27	activation	activation	NN	NN	_	24	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	AP-1	ap-1	NN	NN	_	27	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	PMA	pma	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	18	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	PKC	pkc	NN	NN	_	10	compound	_	_
10	isoforms	isoform	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	alveolar	alveolar	JJ	JJ	_	13	amod	_	_
13	macrophages	macrophage	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	blood	blood	NN	NN	_	16	compound	_	_
16	monocytes	monocyte	NNS	NNS	_	13	conj	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	3	ccomp	_	_
19	with	with	IN	IN	_	22	case	_	_
20	important	important	JJ	JJ	_	22	amod	_	_
21	functional	functional	JJ	JJ	_	22	amod	_	_
22	alterations	alteration	NNS	NNS	_	18	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Acetylation	acetylation	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	modulation	modulation	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
6	Kruppel-like	kruppel-like	JJ	JJ	_	7	amod	_	_
7	factor	factor	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EKLF	eklf	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	activity	activity	NN	NN	_	1	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	interaction	interaction	NN	NN	_	1	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	histone	histone	NN	NN	_	16	compound	_	_
16	acetyltransferases	acetyltransferase	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Erythroid	erythroid	JJ	JJ	_	3	amod	_	_
2	Kruppel-like	kruppel-like	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	12	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EKLF	eklf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	12	cop	_	_
8	a	a	DT	DT	_	12	det	_	_
9	red	red	JJ	JJ	_	12	amod	_	_
10	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activator	activator	NN	NN	_	0	root	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	crucial	crucial	JJ	JJ	_	12	acl:relcl	_	_
16	for	for	IN	IN	_	17	mark	_	_
17	consolidating	consolidate	VBG	VBG	_	15	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	switch	switch	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	high	high	JJ	JJ	_	22	amod	_	_
22	levels	level	NNS	NNS	_	17	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	adult	adult	JJ	JJ	_	26	amod	_	_
25	beta-globin	beta-globin	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	during	during	IN	IN	_	29	case	_	_
28	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
29	ontogeny	ontogeny	NN	NN	_	17	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	EKLF	eklf	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	required	require	VBN	VBN	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	integrity	integrity	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	chromatin	chromatin	NN	NN	_	9	compound	_	_
9	structure	structure	NN	NN	_	5	nmod	_	_
10	at	at	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	beta-like	beta-like	JJ	JJ	_	14	amod	_	_
13	globin	globin	NN	NN	_	14	compound	_	_
14	locus	locus	NN	NN	_	5	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	it	it	PRP	PRP	_	18	nsubj	_	_
18	interacts	interact	VBZ	VBZ	_	3	conj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	positive-acting	positive-acting	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vivo	vivo	FW	FW	_	18	advmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	EKLF	eklf	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	an	a	DT	DT	_	9	det	_	_
7	acetylated	acetylate	VBN	VBN	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	2	ccomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	it	it	PRP	PRP	_	14	nsubj	_	_
14	interacts	interact	VBZ	VBZ	_	9	conj	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vivo	vivo	FW	FW	_	14	advmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	CBP	cbp	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	p300	p300	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	P/CAF	p/caf	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	interactions	interaction	NNS	NNS	_	11	nsubj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	these	these	DT	DT	_	8	det	_	_
7	histone	histone	NN	NN	_	8	compound	_	_
8	acetyltransferases	acetyltransferase	NNS	NNS	_	4	nmod	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	equivalent	equivalent	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	as	as	IN	IN	_	22	mark	_	_
14	CBP	cbp	NN	NN	_	22	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	p300	p300	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	but	but	CC	CC	_	19	cc	_	_
19	not	not	RB	RB	_	14	cc	_	_
20	P/CAF	p/caf	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	utilize	utilize	VBP	VBP	_	11	advcl	_	_
23	EKLF	eklf	NN	NN	_	22	dobj	_	_
24	as	as	IN	IN	_	26	case	_	_
25	a	a	DT	DT	_	26	det	_	_
26	substrate	substrate	NN	NN	_	22	nmod	_	_
27	for	for	IN	IN	_	30	case	_	_
28	in	in	FW	FW	_	30	amod	_	_
29	vitro	vitro	FW	FW	_	28	dep	_	_
30	acetylation	acetylation	NN	NN	_	22	nmod	_	_
31	within	within	IN	IN	_	34	case	_	_
32	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
33	trans-activation	trans-activation	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	interactions	interaction	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	CBP	cbp	NN	NN	_	17	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p300	p300	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	9	cc	_	_
15	P/CAF	p/caf	NN	NN	_	9	conj	_	_
16	,	,	,	,	_	9	punct	_	_
17	enhance	enhance	VBP	VBP	_	7	ccomp	_	_
18	EKLF	eklf	NN	NN	_	21	nmod:poss	_	_
19	's	's	POS	POS	_	18	case	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	17	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	beta-globin	beta-globin	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	erythroid	erythroid	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	17	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	EKLF	eklf	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	tissue-specific	tissue-specific	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	3	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	undergoes	undergo	VBZ	VBZ	_	9	acl:relcl	_	_
12	post-translational	post-translational	JJ	JJ	_	13	amod	_	_
13	acetylation	acetylation	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	suggest	suggest	VBP	VBP	_	3	conj	_	_
16	a	a	DT	DT	_	17	det	_	_
17	mechanism	mechanism	NN	NN	_	15	dobj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	22	nmod	_	_
20	EKLF	eklf	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	able	able	JJ	JJ	_	17	acl:relcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	alter	alter	VB	VB	_	22	xcomp	_	_
25	chromatin	chromatin	NN	NN	_	26	compound	_	_
26	structure	structure	NN	NN	_	24	dobj	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	induce	induce	VB	VB	_	24	conj	_	_
29	beta-globin	beta-globin	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	28	dobj	_	_
31	within	within	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	beta-like	beta-like	JJ	JJ	_	35	amod	_	_
34	globin	globin	NN	NN	_	35	compound	_	_
35	cluster	cluster	NN	NN	_	24	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
2	virus-transforming	virus-transforming	JJ	JJ	_	7	amod	_	_
3	protein	protein	NN	NN	_	7	compound	_	_
4	latent	latent	JJ	JJ	_	7	amod	_	_
5	infection	infection	NN	NN	_	7	compound	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubj	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	activates	activate	VBZ	VBZ	_	0	root	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	9	dobj	_	_
13	through	through	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	pathway	pathway	NN	NN	_	9	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	includes	include	VBZ	VBZ	_	15	acl:relcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	NF-kappaB-inducing	nf-kappab-inducing	NN	NN	_	20	compound	_	_
20	kinase	kinase	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IkappaB	ikappab	NN	NN	_	24	compound	_	_
24	kinases	kinase	NNS	NNS	_	20	conj	_	_
25	IKKalpha	ikkalpha	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IKKbeta	ikkbeta	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	4	amod	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	oncoprotein	oncoprotein	NN	NN	_	20	nsubj	_	_
5	latent	latent	JJ	JJ	_	8	amod	_	_
6	infection	infection	NN	NN	_	8	compound	_	_
7	membrane	membrane	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	4	dep	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LMP1	lmp1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	20	cop	_	_
14	a	a	DT	DT	_	20	det	_	_
15	constitutively	constitutively	RB	RB	_	16	advmod	_	_
16	aggregated	aggregate	VBN	VBN	_	20	amod	_	_
17	pseudo-tumor	pseudo-tumor	NN	NN	_	20	compound	_	_
18	necrosis	necrosis	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	0	root	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TNFR	tnfr	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	activates	activate	VBZ	VBZ	_	20	acl:relcl	_	_
26	transcription	transcription	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	25	dobj	_	_
29	through	through	IN	IN	_	31	case	_	_
30	two	two	CD	CD	_	31	nummod	_	_
31	sites	site	NNS	NNS	_	25	nmod	_	_
32	in	in	IN	IN	_	36	case	_	_
33	its	its	PRP$	PRP$	_	36	nmod:poss	_	_
34	C-terminal	c-terminal	JJ	JJ	_	36	amod	_	_
35	cytoplasmic	cytoplasmic	JJ	JJ	_	36	amod	_	_
36	domain	domain	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	20	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	site	site	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	similar	similar	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	TNFRII	tnfrii	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	associating	associate	VBG	VBG	_	12	case	_	_
10	with	with	IN	IN	_	12	case	_	_
11	TNFR-associated	tnfr-associated	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	4	dep	_	_
13	TRAF1	traf1	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	TRAF2	traf2	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	4	punct	_	_
17	and	and	CC	CC	_	4	cc	_	_
18	the	the	DT	DT	_	20	det	_	_
19	second	second	JJ	JJ	_	20	amod	_	_
20	site	site	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	similar	similar	JJ	JJ	_	4	conj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	TNFRI	tnfri	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	34	case	_	_
26	associating	associate	VBG	VBG	_	34	case	_	_
27	with	with	IN	IN	_	34	case	_	_
28	the	the	DT	DT	_	34	det	_	_
29	TNFRI	tnfri	NN	NN	_	34	compound	_	_
30	death	death	NN	NN	_	34	compound	_	_
31	domain	domain	NN	NN	_	34	compound	_	_
32	interacting	interact	VBG	VBG	_	34	amod	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	TRADD	tradd	NN	NN	_	22	dep	_	_
35	.	.	.	.	_	4	punct	_	_

1	TNFRI	tnfri	NN	NN	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	been	be	VBN	VBN	_	5	auxpass	_	_
4	recently	recently	RB	RB	_	5	advmod	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	5	xcomp	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	7	dobj	_	_
9	through	through	IN	IN	_	10	case	_	_
10	association	association	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	TRADD	tradd	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	RIP	rip	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	TRAF2	traf2	NN	NN	_	12	conj	_	_
18	;	;	:	:	_	10	punct	_	_
19	activation	activation	NN	NN	_	10	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	NF-kappaB-inducing	nf-kappab-inducing	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	NIK	nik	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	;	;	:	:	_	10	punct	_	_
28	activation	activation	NN	NN	_	10	conj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	IkappaB	ikappab	NN	NN	_	33	compound	_	_
32	alpha	alpha	NN	NN	_	33	compound	_	_
33	kinases	kinase	NNS	NNS	_	28	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	IKKalpha	ikkalpha	NN	NN	_	33	dep	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	IKKbeta	ikkbeta	NN	NN	_	35	conj	_	_
38	)	)	-RRB-	-RRB-	_	35	punct	_	_
39	;	;	:	:	_	10	punct	_	_
40	and	and	CC	CC	_	10	cc	_	_
41	phosphorylation	phosphorylation	NN	NN	_	10	conj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	IkappaB	ikappab	NN	NN	_	44	compound	_	_
44	alpha	alpha	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	5	punct	_	_

1	IkappaB	ikappab	NN	NN	_	3	compound	_	_
2	alpha	alpha	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	9	nsubjpass	_	_
4	on	on	IN	IN	_	5	case	_	_
5	Ser-32	ser-32	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Ser-36	ser-36	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	followed	follow	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	degradation	degradation	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	20	nsubjpass	_	_
10	by	by	IN	IN	_	11	case	_	_
11	LMP1	lmp1	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	by	by	IN	IN	_	14	case	_	_
14	each	each	DT	DT	_	11	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	effector	effector	NN	NN	_	18	compound	_	_
18	sites	site	NNS	NNS	_	14	nmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	mediated	mediate	VBN	VBN	_	6	ccomp	_	_
21	by	by	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	pathway	pathway	NN	NN	_	20	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	includes	include	VBZ	VBZ	_	23	acl:relcl	_	_
26	NIK	nik	NN	NN	_	25	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	IKKalpha	ikkalpha	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	IKKbeta	ikkbeta	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	6	punct	_	_

1	Dominant	dominant	JJ	JJ	_	3	amod	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	mutants	mutant	NNS	NNS	_	12	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NIK	nik	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	IKKalpha	ikkalpha	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	or	or	CC	CC	_	5	cc	_	_
10	IKKbeta	ikkbeta	NN	NN	_	5	conj	_	_
11	substantially	substantially	RB	RB	_	12	advmod	_	_
12	inhibited	inhibit	VBD	VBD	_	0	root	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	12	dobj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	LMP1	lmp1	NN	NN	_	14	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	by	by	IN	IN	_	19	case	_	_
19	each	each	DT	DT	_	16	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	effector	effector	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Dimethyldithiocarbamate	dimethyldithiocarbamate	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	in	in	FW	FW	_	5	amod	_	_
4	vitro	vitro	FW	FW	_	3	dep	_	_
5	activation	activation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	primary	primary	JJ	JJ	_	11	amod	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	CD4+	cd4+	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Dithiocarbamates	dithiocarbamate	NNS	NNS	_	17	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	DTC	dtc	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	diverse	diverse	JJ	JJ	_	8	amod	_	_
8	group	group	NN	NN	_	1	appos	_	_
9	of	of	IN	IN	_	13	case	_	_
10	industrial	industrial	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	therapeutic	therapeutic	JJ	JJ	_	10	conj	_	_
13	chemicals	chemical	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	have	have	VBP	VBP	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	reported	report	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	inhibit	inhibit	VB	VB	_	17	xcomp	_	_
20	,	,	,	,	_	19	punct	_	_
21	enhance	enhance	VBP	VBP	_	19	conj	_	_
22	or	or	CC	CC	_	19	cc	_	_
23	have	have	VBP	VBP	_	19	conj	_	_
24	no	no	DT	DT	_	25	neg	_	_
25	effect	effect	NN	NN	_	19	dobj	_	_
26	on	on	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	system	system	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	apparent	apparent	JJ	JJ	_	3	amod	_	_
3	inconsistencies	inconsistency	NNS	NNS	_	4	nsubj	_	_
4	reflect	reflect	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	complexity	complexity	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	DTCs	dtc	NNS	NNS	_	11	compound	_	_
10	biological	biological	JJ	JJ	_	11	amod	_	_
11	activities	activity	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	are	be	VBP	VBP	_	19	cop	_	_
14	probably	probably	RB	RB	_	19	advmod	_	_
15	due	due	JJ	JJ	_	19	case	_	_
16	in	in	IN	IN	_	17	case	_	_
17	part	part	NN	NN	_	19	dep	_	_
18	to	to	TO	TO	_	19	case	_	_
19	differences	difference	NNS	NNS	_	4	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	dose	dose	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	route	route	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	exposure	exposure	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	animal	animal	JJ	JJ	_	28	amod	_	_
28	species	species	NNS	NNS	_	21	conj	_	_
29	used	use	VBN	VBN	_	28	acl	_	_
30	and/or	and/or	CC	CC	_	21	cc	_	_
31	specific	specific	JJ	JJ	_	32	amod	_	_
32	compound	compound	NN	NN	_	21	conj	_	_
33	tested	test	VBN	VBN	_	32	acl	_	_
34	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	6	nsubjpass	_	_
3	described	describe	VBN	VBN	_	2	acl	_	_
4	herein	herein	RB	RB	_	3	advmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	undertaken	undertake	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	investigate	investigate	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	immunotoxicity	immunotoxicity	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	member	member	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	family	family	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	13	punct	_	_
18	dimethyldithiocarbamate	dimethyldithiocarbamate	NN	NN	_	13	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	DMDTC	dmdtc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	0.1-0.5	0.1-0.5	CD	CD	_	5	dep	_	_
5	microM	microm	NN	NN	_	6	dep	_	_
6	DMDTC	dmdtc	NN	NN	_	7	nsubj	_	_
7	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
8	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	primary	primary	JJ	JJ	_	17	amod	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	CD4+	cd4+	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	accompanied	accompany	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	loss	loss	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	viability	viability	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	DMDTC-treated	dmdtc-treated	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	16	nsubj	_	_
16	retain	retain	VBP	VBP	_	5	conj	_	_
17	other	other	JJ	JJ	_	20	amod	_	_
18	active	active	JJ	JJ	_	20	amod	_	_
19	signaling	signaling	NN	NN	_	20	compound	_	_
20	pathways	pathway	NNS	NNS	_	16	dobj	_	_
21	throughout	throughout	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	exposure	exposure	NN	NN	_	24	compound	_	_
24	duration	duration	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	apparently	apparently	RB	RB	_	7	advmod	_	_
7	permanent	permanent	JJ	JJ	_	0	root	_	_
8	as	as	IN	IN	_	14	mark	_	_
9	DMDTC-treated	dmdtc-treated	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	regain	regain	VB	VB	_	7	advcl	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	7	punct	_	_
19	even	even	RB	RB	_	22	advmod	_	_
20	after	after	IN	IN	_	22	case	_	_
21	72	72	CD	CD	_	22	nummod	_	_
22	h	h	NN	NN	_	7	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	culture	culture	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	DMDTC	dmdtc	NN	NN	_	4	nsubj	_	_
2	does	do	VBZ	VBZ	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	appear	appear	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	alter	alter	VB	VB	_	4	xcomp	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	6	dobj	_	_
8	directly	directly	RB	RB	_	6	advmod	_	_
9	as	as	IN	IN	_	18	mark	_	_
10	pre-incubation	pre-incubation	NN	NN	_	18	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	extracts	extract	NNS	NNS	_	10	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	DMDTC	dmdtc	NN	NN	_	10	nmod	_	_
16	does	do	VBZ	VBZ	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	diminish	diminish	VB	VB	_	6	advcl	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	this	this	DT	DT	_	23	det	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	0.1-0.5	0.1-0.5	CD	CD	_	6	dep	_	_
6	microM	microm	NN	NN	_	7	dep	_	_
7	DMDTC	dmdtc	NN	NN	_	8	nsubj	_	_
8	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
9	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	8	dobj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	decreases	decrease	VBZ	VBZ	_	8	conj	_	_
14	surface	surface	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CD25	cd25	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	alpha	alpha	NN	NN	_	21	compound	_	_
21	subunit	subunit	NN	NN	_	17	dep	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	IL-2	il-2	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	21	nmod	_	_
26	)	)	-RRB-	-RRB-	_	21	punct	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	15	nmod	_	_
30	stimulated	stimulate	VBN	VBN	_	29	acl	_	_
31	with	with	IN	IN	_	33	case	_	_
32	phorbol	phorbol	NN	NN	_	33	compound	_	_
33	ester	ester	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	DMDTC	dmdtc	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	potent	potent	JJ	JJ	_	10	amod	_	_
9	immunosuppressive	immunosuppressive	JJ	JJ	_	10	amod	_	_
10	compound	compound	NN	NN	_	3	ccomp	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	10	advmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	13	nsubj	_	_
4	in	in	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	CD95	cd95	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	APO-1/Fas	apo-1/fas	NN	NN	_	11	compound	_	_
9	)	)	-RRB-	-RRB-	_	11	punct	_	_
10	ligand	ligand	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	3	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	essential	essential	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	15	case	_	_
15	responsiveness	responsiveness	NN	NN	_	13	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	TCR-mediated	tcr-mediated	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Expression	expression	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	CD95	cd95	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	APO-1/Fas	apo-1/fas	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	ligand	ligand	NN	NN	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CD95L	cd95l	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	1	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	major	major	JJ	JJ	_	19	amod	_	_
19	cause	cause	NN	NN	_	0	root	_	_
20	of	of	IN	IN	_	24	case	_	_
21	T	t	NN	NN	_	23	nmod:npmod	_	_
22	cell	cell	NN	NN	_	23	nmod:npmod	_	_
23	activation-induced	activation-induced	JJ	JJ	_	24	amod	_	_
24	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	17	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	control	control	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	CD95L	cd95l	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	investigated	investigate	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	21	det	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	CD95L	cd95l	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	Jurkat	jurkat	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	17	punct	_	_

1	Deletion	deletion	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	CD95L	cd95l	NN	NN	_	9	compound	_	_
7	proximal	proximal	JJ	JJ	_	9	amod	_	_
8	promoter	promoter	NN	NN	_	9	compound	_	_
9	sequence	sequence	NN	NN	_	18	nsubj	_	_
10	from	from	IN	IN	_	11	case	_	_
11	-220	-220	CD	CD	_	9	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	start	start	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	9	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	essential	essential	JJ	JJ	_	3	ccomp	_	_
19	for	for	IN	IN	_	23	case	_	_
20	T	t	NN	NN	_	22	nmod:npmod	_	_
21	cell	cell	NN	NN	_	22	nmod:npmod	_	_
22	stimulation-induced	stimulation-induced	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	CD95L	cd95l	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	discovered	discover	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	novel	novel	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	6	dobj	_	_
11	located	located	JJ	JJ	_	10	amod	_	_
12	at	at	IN	IN	_	13	case	_	_
13	-120	-120	CD	CD	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CD95L	cd95l	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	contains	contain	VBZ	VBZ	_	10	acl:relcl	_	_
20	DNA	dna	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	sites	site	NNS	NNS	_	19	dobj	_	_
23	for	for	IN	IN	_	24	case	_	_
24	SP-1	sp-1	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	a	a	DT	DT	_	30	det	_	_
27	yet	yet	RB	RB	_	28	advmod	_	_
28	unknown	unknown	JJ	JJ	_	30	amod	_	_
29	inducible	inducible	JJ	JJ	_	30	amod	_	_
30	factor	factor	NN	NN	_	24	conj	_	_
31	.	.	.	.	_	6	punct	_	_

1	Mutation	mutation	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	binding	binding	NN	NN	_	15	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	inducible	inducible	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	5	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	-120	-120	CD	CD	_	13	nummod	_	_
13	region	region	NN	NN	_	5	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	crucial	crucial	JJ	JJ	_	3	ccomp	_	_
16	for	for	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	biological	biological	JJ	JJ	_	19	amod	_	_
19	function	function	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	CD95L	cd95l	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	upon	upon	IN	IN	_	27	case	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	stimulation	stimulation	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	7	nsubj	_	_
4	at	at	IN	IN	_	5	case	_	_
5	-120	-120	CD	CD	_	3	nmod	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	contains	contain	VBZ	VBZ	_	0	root	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	motifs	motif	NNS	NNS	_	7	dobj	_	_
11	homologous	homologous	JJ	JJ	_	10	amod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	binding	bind	VBG	VBG	_	15	amod	_	_
15	site	site	NN	NN	_	11	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	NF-AT	nf-at	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	NF-AT	nf-at	NN	NN	_	5	nsubj	_	_
2	does	do	VBZ	VBZ	_	5	aux	_	_
3	not	not	RB	RB	_	5	neg	_	_
4	directly	directly	RB	RB	_	5	advmod	_	_
5	bind	bind	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	element	element	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	cotransfection	cotransfection	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	10	nsubj	_	_
5	with	with	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	NF-AT	nf-at	NN	NN	_	9	compound	_	_
8	expression	expression	NN	NN	_	9	compound	_	_
9	vector	vector	NN	NN	_	4	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	NF-AT	nf-at	NN	NN	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	confer	confer	VB	VB	_	10	ccomp	_	_
15	a	a	DT	DT	_	18	det	_	_
16	strong	strong	JJ	JJ	_	18	amod	_	_
17	inducible	inducible	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	14	dobj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	CD95L	cd95l	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	14	nmod	_	_
23	at	at	IN	IN	_	26	case	_	_
24	this	this	DT	DT	_	26	det	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	region	region	NN	NN	_	14	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	immunosuppressive	immunosuppressive	JJ	JJ	_	10	amod	_	_
8	agent	agent	NN	NN	_	10	compound	_	_
9	cyclosporin	cyclosporin	NN	NN	_	10	compound	_	_
10	A	a	NN	NN	_	11	nsubj	_	_
11	down-regulates	down-regulate	VBZ	VBZ	_	4	ccomp	_	_
12	CD95L	cd95l	NN	NN	_	13	compound	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	inhibiting	inhibit	VBG	VBG	_	11	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	function	function	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	this	this	DT	DT	_	22	det	_	_
20	positive	positive	JJ	JJ	_	22	amod	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	element	element	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Highly	highly	RB	RB	_	2	advmod	_	_
2	polarized	polarize	VBN	VBN	_	7	amod	_	_
3	HLA	hla	NN	NN	_	7	compound	_	_
4	class	class	NN	NN	_	7	compound	_	_
5	II	ii	CD	CD	_	7	nummod	_	_
6	antigen	antigen	NN	NN	_	7	compound	_	_
7	processing	processing	NN	NN	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	presentation	presentation	NN	NN	_	7	conj	_	_
10	by	by	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	intestinal	intestinal	JJ	JJ	_	14	amod	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	high	high	JJ	JJ	_	3	amod	_	_
3	concentration	concentration	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	foreign	foreign	JJ	JJ	_	6	amod	_	_
6	antigen	antigen	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	lumen	lumen	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	gastrointestinal	gastrointestinal	JJ	JJ	_	13	amod	_	_
13	tract	tract	NN	NN	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	separated	separate	VBN	VBN	_	0	root	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	underlying	underlie	VBG	VBG	_	19	amod	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
20	by	by	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	single	single	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	layer	layer	NN	NN	_	15	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	polarized	polarize	VBN	VBN	_	27	amod	_	_
27	epithelium	epithelium	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	Intestinal	intestinal	JJ	JJ	_	3	amod	_	_
2	epithelial	epithelial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	express	express	VB	VB	_	0	root	_	_
6	HLA	hla	NN	NN	_	9	compound	_	_
7	class	class	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	antigens	antigen	NNS	NNS	_	5	dobj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	function	function	VB	VB	_	5	conj	_	_
13	as	as	IN	IN	_	19	case	_	_
14	antigen-presenting	antigen-presenting	JJ	JJ	_	19	amod	_	_
15	cells	cell	NNS	NNS	_	19	compound	_	_
16	to	to	TO	TO	_	19	dep	_	_
17	CD4(+)	cd4(+)	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	within	within	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	intestinal	intestinal	JJ	JJ	_	23	amod	_	_
23	mucosa	mucosa	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	tetanus	tetanus	NN	NN	_	3	compound	_	_
3	toxoid	toxoid	NN	NN	_	1	dobj	_	_
4	specific	specific	JJ	JJ	_	3	amod	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	HLA-DR-restricted	hla-dr-restricted	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	3	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	show	show	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	23	mark	_	_
13	polarized	polarize	VBN	VBN	_	16	amod	_	_
14	intestinal	intestinal	JJ	JJ	_	16	amod	_	_
15	epithelial	epithelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	23	nsubj	_	_
17	directed	direct	VBN	VBN	_	16	acl	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	express	express	VB	VB	_	17	xcomp	_	_
20	HLA-DR	hla-dr	NN	NN	_	21	compound	_	_
21	molecules	molecule	NNS	NNS	_	19	dobj	_	_
22	are	be	VBP	VBP	_	23	cop	_	_
23	able	able	JJ	JJ	_	11	ccomp	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	initiate	initiate	VB	VB	_	23	xcomp	_	_
26	class	class	NN	NN	_	28	compound	_	_
27	II	ii	CD	CD	_	28	nummod	_	_
28	processing	processing	NN	NN	_	25	dobj	_	_
29	only	only	RB	RB	_	25	advcl	_	_
30	after	after	IN	IN	_	31	case	_	_
31	internalization	internalization	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	antigen	antigen	NN	NN	_	31	nmod	_	_
34	from	from	IN	IN	_	37	case	_	_
35	their	they	PRP$	PRP$	_	37	nmod:poss	_	_
36	apical	apical	JJ	JJ	_	37	amod	_	_
37	surface	surface	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	11	punct	_	_

1	Coexpression	coexpression	NN	NN	_	37	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	class	class	NN	NN	_	7	compound	_	_
5	II	ii	CD	CD	_	7	nummod	_	_
6	transactivator	transactivator	NN	NN	_	7	compound	_	_
7	CIITA	ciita	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	stimulates	stimulate	VBZ	VBZ	_	1	acl:relcl	_	_
14	highly	highly	RB	RB	_	18	advmod	_	_
15	efficient	efficient	JJ	JJ	_	18	amod	_	_
16	class	class	NN	NN	_	18	compound	_	_
17	II	ii	CD	CD	_	18	nummod	_	_
18	processing	processing	NN	NN	_	13	dobj	_	_
19	without	without	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	characteristic	characteristic	JJ	JJ	_	22	amod	_	_
22	decline	decline	NN	NN	_	13	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	barrier	barrier	NN	NN	_	25	compound	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	seen	see	VBN	VBN	_	25	acl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	polarized	polarize	VBN	VBN	_	29	amod	_	_
29	monolayers	monolayer	NNS	NNS	_	26	nmod	_	_
30	treated	treat	VBN	VBN	_	29	acl	_	_
31	with	with	IN	IN	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	proinflammatory	proinflammatory	JJ	JJ	_	35	amod	_	_
34	cytokine	cytokine	NN	NN	_	35	compound	_	_
35	gamma-IFN	gamma-ifn	NN	NN	_	30	nmod	_	_
36	,	,	,	,	_	37	punct	_	_
37	facilitates	facilitate	VBZ	VBZ	_	0	root	_	_
38	antigen	antigen	NN	NN	_	39	compound	_	_
39	processing	processing	NN	NN	_	37	dobj	_	_
40	from	from	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	basolateral	basolateral	JJ	JJ	_	43	amod	_	_
43	surface	surface	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	37	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	both	both	DT	DT	_	3	det	_	_
3	cases	case	NNS	NNS	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	peptide	peptide	NN	NN	_	6	compound	_	_
6	presentation	presentation	NN	NN	_	15	nsubj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	via	via	IN	IN	_	13	case	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	molecules	molecule	NNS	NNS	_	6	nmod	_	_
14	was	be	VBD	VBD	_	15	aux	_	_
15	restricted	restricted	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	basolateral	basolateral	JJ	JJ	_	19	amod	_	_
19	surface	surface	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	highly	highly	RB	RB	_	8	advmod	_	_
6	polarized	polarize	VBN	VBN	_	8	amod	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	architecture	architecture	NN	NN	_	3	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	antigen	antigen	NN	NN	_	11	compound	_	_
11	processing	processing	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	presentation	presentation	NN	NN	_	11	conj	_	_
14	by	by	IN	IN	_	17	case	_	_
15	intestinal	intestinal	JJ	JJ	_	17	amod	_	_
16	epithelial	epithelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	33	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	functional	functional	JJ	JJ	_	24	amod	_	_
24	outcome	outcome	NN	NN	_	33	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	antigen	antigen	NN	NN	_	27	compound	_	_
27	processing	processing	NN	NN	_	24	nmod	_	_
28	by	by	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	intestinal	intestinal	JJ	JJ	_	31	amod	_	_
31	epithelium	epithelium	NN	NN	_	27	nmod	_	_
32	is	be	VBZ	VBZ	_	33	cop	_	_
33	both	both	CC	CC	_	20	ccomp	_	_
34	dependent	dependent	JJ	JJ	_	33	dep	_	_
35	on	on	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	cellular	cellular	JJ	JJ	_	38	amod	_	_
38	surface	surface	NN	NN	_	34	nmod	_	_
39	at	at	IN	IN	_	40	case	_	_
40	which	which	WDT	WDT	_	45	nmod	_	_
41	the	the	DT	DT	_	43	det	_	_
42	foreign	foreign	JJ	JJ	_	43	amod	_	_
43	antigen	antigen	NN	NN	_	45	nsubjpass	_	_
44	is	be	VBZ	VBZ	_	45	auxpass	_	_
45	internalized	internalize	VBN	VBN	_	38	acl:relcl	_	_
46	and	and	CC	CC	_	33	cc	_	_
47	by	by	IN	IN	_	50	case	_	_
48	the	the	DT	DT	_	50	det	_	_
49	underlying	underlying	JJ	JJ	_	50	amod	_	_
50	degree	degree	NN	NN	_	33	conj	_	_
51	of	of	IN	IN	_	53	case	_	_
52	mucosal	mucosal	JJ	JJ	_	53	amod	_	_
53	inflammation	inflammation	NN	NN	_	50	nmod	_	_
54	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	small	small	JJ	JJ	_	5	amod	_	_
3	GTP-binding	gtp-binding	JJ	JJ	_	5	amod	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	Rho	rho	NN	NN	_	6	nsubj	_	_
6	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Rho	rho	NN	NN	_	3	compound	_	_
3	family	family	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	small	small	JJ	JJ	_	7	amod	_	_
6	GTP-binding	gtp-binding	JJ	JJ	_	7	amod	_	_
7	proteins	protein	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	regulation	regulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cytoskeletal	cytoskeletal	JJ	JJ	_	15	amod	_	_
15	structure	structure	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	specific	specific	JJ	JJ	_	23	amod	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	fate	fate	NN	NN	_	23	compound	_	_
23	development	development	NN	NN	_	15	conj	_	_
24	,	,	,	,	_	15	punct	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	transformation	transformation	NN	NN	_	15	conj	_	_
27	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	report	report	NN	NN	_	2	nmod	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	overexpression	overexpression	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	activated	activated	JJ	JJ	_	11	amod	_	_
11	form	form	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Rho	rho	NN	NN	_	11	nmod	_	_
14	enhances	enhance	VBZ	VBZ	_	2	ccomp	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	Jurkat	jurkat	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	presence	presence	NN	NN	_	14	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	phorbol	phorbol	NN	NN	_	27	compound	_	_
26	myristate	myristate	NN	NN	_	27	compound	_	_
27	acetate	acetate	NN	NN	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	PMA	pma	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	14	punct	_	_
32	but	but	CC	CC	_	14	cc	_	_
33	activated	activate	VBN	VBN	_	34	amod	_	_
34	Rho	rho	NN	NN	_	38	nsubj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	V14Rho	v14rho	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	has	have	VBZ	VBZ	_	14	conj	_	_
39	little	little	JJ	JJ	_	42	amod	_	_
40	or	or	CC	CC	_	39	cc	_	_
41	no	no	DT	DT	_	39	conj	_	_
42	effect	effect	NN	NN	_	38	dobj	_	_
43	on	on	IN	IN	_	52	case	_	_
44	NFAT	nfat	NN	NN	_	52	compound	_	_
45	,	,	,	,	_	44	punct	_	_
46	Oct-1	oct-1	NN	NN	_	44	conj	_	_
47	,	,	,	,	_	44	punct	_	_
48	and	and	CC	CC	_	44	cc	_	_
49	NF-kappaB	nf-kappab	NN	NN	_	51	compound	_	_
50	enhancer	enhancer	NN	NN	_	51	compound	_	_
51	element	element	NN	NN	_	44	conj	_	_
52	activities	activity	NNS	NNS	_	42	nmod	_	_
53	under	under	IN	IN	_	55	case	_	_
54	similar	similar	JJ	JJ	_	55	amod	_	_
55	conditions	condition	NNS	NNS	_	38	nmod	_	_
56	.	.	.	.	_	2	punct	_	_

1	Overexpression	overexpression	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	V14Rho	v14rho	NN	NN	_	5	compound	_	_
5	construct	construct	NN	NN	_	1	nmod	_	_
6	incapable	incapable	JJ	JJ	_	5	amod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	localization	localization	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CAAX	caax	NN	NN	_	9	appos	_	_
12	deleted	delete	VBN	VBN	_	11	acl	_	_
13	)	)	-RRB-	-RRB-	_	11	punct	_	_
14	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
15	PMA-induced	pma-induced	JJ	JJ	_	18	amod	_	_
16	AP-1	ap-1	NN	NN	_	18	compound	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Rho	rho	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	6	case	_	_
6	AP-1	ap-1	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	independent	independent	JJ	JJ	_	0	root	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	mitogen-activated	mitogen-activated	JJ	JJ	_	14	amod	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	as	as	IN	IN	_	29	mark	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dominant-negative	dominant-negative	JJ	JJ	_	19	amod	_	_
19	MEK	mek	NN	NN	_	29	nsubj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	MEK	mek	NN	NN	_	23	compound	_	_
23	inhibitor	inhibitor	NN	NN	_	19	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PD98059	pd98059	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	did	do	VBD	VBD	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	affect	affect	VB	VB	_	8	advcl	_	_
30	Rho-induced	rho-induced	JJ	JJ	_	32	amod	_	_
31	AP-1	ap-1	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	V14Rho	v14rho	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	strongly	strongly	RB	RB	_	2	advmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	Calpha	calpha	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PKCalpha	pkcalpha	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	2	advmod	_	_
13	;	;	:	:	_	2	punct	_	_
14	however	however	RB	RB	_	2	advmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	deletion	deletion	NN	NN	_	24	nsubj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	CAAX	caax	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	16	nmod	_	_
21	on	on	IN	IN	_	22	case	_	_
22	V14Rho	v14rho	NN	NN	_	20	nmod	_	_
23	severely	severely	RB	RB	_	24	advmod	_	_
24	diminished	diminish	VBD	VBD	_	2	dep	_	_
25	this	this	DT	DT	_	26	det	_	_
26	association	association	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	2	punct	_	_

1	Evidence	evidence	NN	NN	_	13	nsubjpass	_	_
2	for	for	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	PKCalpha	pkcalpha	NN	NN	_	4	nmod	_	_
7	as	as	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	effector	effector	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Rho	rho	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	obtained	obtain	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	observation	observation	NN	NN	_	13	nmod	_	_
17	that	that	IN	IN	_	25	mark	_	_
18	coexpression	coexpression	NN	NN	_	25	nsubj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	N-terminal	n-terminal	JJ	JJ	_	22	amod	_	_
22	domain	domain	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	PKCalpha	pkcalpha	NN	NN	_	22	nmod	_	_
25	blocked	block	VBD	VBD	_	16	dep	_	_
26	the	the	DT	DT	_	27	det	_	_
27	effects	effect	NNS	NNS	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	activated	activate	VBN	VBN	_	30	amod	_	_
30	Rho	rho	NN	NN	_	27	nmod	_	_
31	plus	plus	CC	CC	_	30	cc	_	_
32	PMA	pma	NN	NN	_	30	conj	_	_
33	on	on	IN	IN	_	36	case	_	_
34	AP-1	ap-1	NN	NN	_	36	compound	_	_
35	transcriptional	transcriptional	JJ	JJ	_	36	amod	_	_
36	activity	activity	NN	NN	_	27	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Rho	rho	NN	NN	_	6	nsubj	_	_
6	potentiates	potentiate	VBZ	VBZ	_	3	ccomp	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	during	during	IN	IN	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	8	amod	_	_
2	T-cell	t-cell	NN	NN	_	8	compound	_	_
3	leukemia	leukemia	NN	NN	_	8	compound	_	_
4	virus	virus	NN	NN	_	8	compound	_	_
5	type	type	NN	NN	_	8	compound	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	Tax	tax	NN	NN	_	8	compound	_	_
8	induction	induction	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	involves	involve	VBZ	VBZ	_	0	root	_	_
12	activation	activation	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	IkappaB	ikappab	NN	NN	_	17	compound	_	_
16	kinase	kinase	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	IKKalpha	ikkalpha	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	IKKbeta	ikkbeta	NN	NN	_	17	conj	_	_
23	cellular	cellular	JJ	JJ	_	24	amod	_	_
24	kinases	kinase	NNS	NNS	_	22	dep	_	_
25	.	.	.	.	_	11	punct	_	_

1	Tax	tax	NN	NN	_	2	nsubj	_	_
2	corresponds	correspond	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	40-kDa	40-kda	JJ	JJ	_	7	amod	_	_
6	transforming	transform	VBG	VBG	_	7	amod	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	from	from	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	det	_	_
10	pathogenic	pathogenic	JJ	JJ	_	16	amod	_	_
11	retrovirus	retrovirus	NN	NN	_	16	compound	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	T-cell	t-cell	NN	NN	_	16	compound	_	_
14	leukemia	leukemia	NN	NN	_	16	compound	_	_
15	virus	virus	NN	NN	_	16	compound	_	_
16	type	type	NN	NN	_	7	nmod	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HTLV-1	htlv-1	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	activates	activate	VBZ	VBZ	_	16	acl:relcl	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	28	compound	_	_
28	family	family	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factors	factor	NNS	NNS	_	28	nmod	_	_
32	by	by	IN	IN	_	35	case	_	_
33	an	a	DT	DT	_	35	det	_	_
34	unknown	unknown	JJ	JJ	_	35	amod	_	_
35	mechanism	mechanism	NN	NN	_	22	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Tax	tax	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	promotes	promote	VBZ	VBZ	_	0	root	_	_
4	N-terminal	n-terminal	JJ	JJ	_	5	amod	_	_
5	phosphorylation	phosphorylation	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	degradation	degradation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IkappaB	ikappab	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	15	det	_	_
13	principal	principal	JJ	JJ	_	15	amod	_	_
14	cytoplasmic	cytoplasmic	JJ	JJ	_	15	amod	_	_
15	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	HTLV-1	htlv-1	NN	NN	_	8	nsubj	_	_
7	Tax	tax	NN	NN	_	6	dep	_	_
8	activates	activate	VBZ	VBZ	_	4	ccomp	_	_
9	the	the	DT	DT	_	13	det	_	_
10	recently	recently	RB	RB	_	11	advmod	_	_
11	identified	identify	VBN	VBN	_	13	amod	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	kinases	kinase	NNS	NNS	_	8	dobj	_	_
14	IkappaB	ikappab	NN	NN	_	16	compound	_	_
15	kinase	kinase	NN	NN	_	16	compound	_	_
16	alpha	alpha	NN	NN	_	13	dep	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IKKalpha	ikkalpha	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	IKKbeta	ikkbeta	NN	NN	_	16	conj	_	_
22	,	,	,	,	_	13	punct	_	_
23	which	which	WDT	WDT	_	25	nsubj	_	_
24	normally	normally	RB	RB	_	25	advmod	_	_
25	phosphorylate	phosphorylate	VBP	VBP	_	13	acl:relcl	_	_
26	IkappaB	ikappab	NN	NN	_	27	compound	_	_
27	alpha	alpha	NN	NN	_	25	dobj	_	_
28	on	on	IN	IN	_	29	case	_	_
29	both	both	DT	DT	_	25	nmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
32	N-terminal	n-terminal	JJ	JJ	_	34	amod	_	_
33	regulatory	regulatory	JJ	JJ	_	34	amod	_	_
34	serines	serine	NNS	NNS	_	29	nmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	response	response	NN	NN	_	25	nmod	_	_
37	to	to	TO	TO	_	41	case	_	_
38	tumor	tumor	NN	NN	_	41	compound	_	_
39	necrosis	necrosis	NN	NN	_	41	compound	_	_
40	factor	factor	NN	NN	_	41	compound	_	_
41	alpha	alpha	NN	NN	_	36	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	TNF-alpha	tnf-alpha	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	and	and	CC	CC	_	41	cc	_	_
46	interleukin-1	interleukin-1	NN	NN	_	50	compound	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	IL-1	il-1	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	stimulation	stimulation	NN	NN	_	41	conj	_	_
51	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	a	a	DT	DT	_	5	det	_	_
5	mutant	mutant	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	termed	term	VBN	VBN	_	7	acl	_	_
9	M22	m22	NN	NN	_	8	xcomp	_	_
10	,	,	,	,	_	5	punct	_	_
11	which	which	WDT	WDT	_	14	nsubj	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	induce	induce	VB	VB	_	5	acl:relcl	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	17	punct	_	_
17	fails	fail	VBZ	VBZ	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	activate	activate	VB	VB	_	17	xcomp	_	_
20	either	either	CC	CC	_	21	cc:preconj	_	_
21	IKKalpha	ikkalpha	NN	NN	_	19	dobj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	IKKbeta	ikkbeta	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	17	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	endogenous	endogenous	JJ	JJ	_	6	amod	_	_
4	IKK	ikk	NN	NN	_	5	nmod:npmod	_	_
5	enzymatic	enzymatic	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	9	nsubj	_	_
7	was	be	VBD	VBD	_	9	aux	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	elevated	elevated	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	HTLV-1-infected	htlv-1-infected	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Tax-expressing	tax-expressing	JJ	JJ	_	11	conj	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Transfection	transfection	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	kinase-deficient	kinase-deficient	JJ	JJ	_	4	amod	_	_
4	mutants	mutant	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IKKalpha	ikkalpha	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IKKbeta	ikkbeta	NN	NN	_	6	conj	_	_
9	into	into	IN	IN	_	13	case	_	_
10	either	either	CC	CC	_	13	cc:preconj	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	Jurkat	jurkat	NN	NN	_	13	compound	_	_
13	T	t	NN	NN	_	1	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	293	293	CD	CD	_	13	conj	_	_
16	cells	cell	NNS	NNS	_	13	dep	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
19	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	22	amod	_	_
20	reporter	reporter	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	dobj	_	_
23	induced	induce	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	Tax	tax	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	Similarly	similarly	RB	RB	_	32	advmod	_	_
2	,	,	,	,	_	32	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	kinase-deficient	kinase-deficient	JJ	JJ	_	5	amod	_	_
5	mutant	mutant	NN	NN	_	32	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NIK	nik	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	NF-kappaB-inducing	nf-kappab-inducing	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	5	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	represents	represent	VBZ	VBZ	_	5	acl:relcl	_	_
15	an	a	DT	DT	_	17	det	_	_
16	upstream	upstream	JJ	JJ	_	17	amod	_	_
17	kinase	kinase	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	TNF-alpha	tnf-alpha	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IL-1	il-1	NN	NN	_	20	conj	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathways	pathway	NNS	NNS	_	20	dep	_	_
25	leading	lead	VBG	VBG	_	20	acl	_	_
26	to	to	TO	TO	_	27	case	_	_
27	IKKalpha	ikkalpha	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	IKKbeta	ikkbeta	NN	NN	_	27	conj	_	_
30	activation	activation	NN	NN	_	27	dep	_	_
31	,	,	,	,	_	32	punct	_	_
32	blocks	block	VBZ	VBZ	_	0	root	_	_
33	Tax	tax	NN	NN	_	34	compound	_	_
34	induction	induction	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	NF-kappaB	nf-kappab	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	32	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	plasma	plasma	NN	NN	_	5	compound	_	_
4	membrane-proximal	membrane-proximal	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	14	nsubjpass	_	_
6	in	in	IN	IN	_	10	case	_	_
7	these	these	DT	DT	_	10	det	_	_
8	proinflammatory	proinflammatory	JJ	JJ	_	10	amod	_	_
9	cytokine	cytokine	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	5	nmod	_	_
11	are	be	VBP	VBP	_	14	auxpass	_	_
12	apparently	apparently	RB	RB	_	14	advmod	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	involved	involve	VBN	VBN	_	0	root	_	_
15	since	since	IN	IN	_	45	mark	_	_
16	dominant	dominant	JJ	JJ	_	18	amod	_	_
17	negative	negative	JJ	JJ	_	18	amod	_	_
18	mutants	mutant	NNS	NNS	_	45	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	TRAF2	traf2	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	TRAF6	traf6	NN	NN	_	21	conj	_	_
24	adaptors	adaptor	NNS	NNS	_	21	dep	_	_
25	,	,	,	,	_	18	punct	_	_
26	which	which	WDT	WDT	_	28	nsubj	_	_
27	effectively	effectively	RB	RB	_	28	advmod	_	_
28	block	block	VBP	VBP	_	18	acl:relcl	_	_
29	signaling	signaling	NN	NN	_	28	dobj	_	_
30	through	through	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	cytoplasmic	cytoplasmic	JJ	JJ	_	33	amod	_	_
33	tails	tail	NNS	NNS	_	28	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	TNF-alpha	tnf-alpha	NN	NN	_	33	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	IL-1	il-1	NN	NN	_	36	conj	_	_
39	receptors	receptor	NNS	NNS	_	36	dep	_	_
40	,	,	,	,	_	45	punct	_	_
41	respectively	respectively	RB	RB	_	45	advmod	_	_
42	,	,	,	,	_	45	punct	_	_
43	do	do	VBP	VBP	_	45	aux	_	_
44	not	not	RB	RB	_	45	neg	_	_
45	inhibit	inhibit	VB	VB	_	14	advcl	_	_
46	Tax	tax	NN	NN	_	47	compound	_	_
47	induction	induction	NN	NN	_	45	dobj	_	_
48	of	of	IN	IN	_	49	case	_	_
49	NF-kappaB	nf-kappab	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	14	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	HTLV-1	htlv-1	NN	NN	_	9	nsubj	_	_
8	Tax	tax	NN	NN	_	7	dep	_	_
9	exploits	exploit	VBZ	VBZ	_	5	ccomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	distal	distal	JJ	JJ	_	12	amod	_	_
12	part	part	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	proinflammatory	proinflammatory	JJ	JJ	_	18	amod	_	_
16	cytokine	cytokine	NN	NN	_	18	compound	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	cascade	cascade	NN	NN	_	12	nmod	_	_
19	leading	lead	VBG	VBG	_	18	acl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	induction	induction	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	pathological	pathological	JJ	JJ	_	3	amod	_	_
3	alteration	alteration	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	3	nmod	_	_
8	leading	lead	VBG	VBG	_	7	acl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Tax	tax	NN	NN	_	11	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	play	play	VB	VB	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	central	central	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	HTLV-1-mediated	htlv-1-mediated	JJ	JJ	_	21	amod	_	_
21	transformation	transformation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	clinically	clinically	RB	RB	_	28	advmod	_	_
28	manifested	manifest	VBN	VBN	_	21	acl	_	_
29	as	as	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	adult	adult	JJ	JJ	_	33	amod	_	_
32	T-cell	t-cell	NN	NN	_	33	compound	_	_
33	leukemia	leukemia	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	Class	class	NN	NN	_	3	nmod:npmod	_	_
2	II	ii	CD	CD	_	3	compound	_	_
3	transactivator-independent	transactivator-independent	JJ	JJ	_	10	amod	_	_
4	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
5	cell	cell	NN	NN	_	10	compound	_	_
6	MHC	mhc	NN	NN	_	10	compound	_	_
7	class	class	NN	NN	_	10	compound	_	_
8	II	ii	CD	CD	_	10	nummod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	0	root	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	adhesion	adhesion	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	NK	nk	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	induce	induce	VBP	VBP	_	0	root	_	_
4	MHC	mhc	NN	NN	_	7	compound	_	_
5	class	class	NN	NN	_	7	compound	_	_
6	II	ii	CD	CD	_	7	nummod	_	_
7	molecules	molecule	NNS	NNS	_	3	dobj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	surface	surface	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	allogeneic	allogeneic	JJ	JJ	_	14	amod	_	_
13	endothelial	endothelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	an	a	DT	DT	_	20	det	_	_
17	adhesion-dependent	adhesion-dependent	JJ	JJ	_	20	amod	_	_
18	,	,	,	,	_	17	punct	_	_
19	IFN-gamma-independent	ifn-gamma-independent	JJ	JJ	_	17	dep	_	_
20	manner	manner	NN	NN	_	3	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	NK	nk	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	induce	induce	VBP	VBP	_	4	ccomp	_	_
9	HLA-DR	hla-dr	NN	NN	_	8	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	surface	surface	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	mutant	mutant	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	12	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	defective	defective	JJ	JJ	_	17	acl:relcl	_	_
21	in	in	IN	IN	_	26	case	_	_
22	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	26	amod	_	_
23	MHC	mhc	NN	NN	_	26	compound	_	_
24	class	class	NN	NN	_	26	compound	_	_
25	II	ii	CD	CD	_	26	nummod	_	_
26	expression	expression	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	RNA	rna	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	21	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	5	conj	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	defective	defective	JJ	JJ	_	10	acl:relcl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	class	class	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	17	nummod	_	_
17	transactivator	transactivator	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CIITA	ciita	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
22	that	that	IN	IN	_	31	mark	_	_
23	NK	nk	NN	NN	_	24	nmod:npmod	_	_
24	cell-induced	cell-induced	JJ	JJ	_	28	amod	_	_
25	HLA-DR	hla-dr	NN	NN	_	28	compound	_	_
26	alpha	alpha	NN	NN	_	28	compound	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	31	nsubj	_	_
29	is	be	VBZ	VBZ	_	31	cop	_	_
30	also	also	RB	RB	_	31	advmod	_	_
31	CIITA-independent	ciita-independent	JJ	JJ	_	21	ccomp	_	_
32	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	Janus	janus	NN	NN	_	6	compound	_	_
3	kinase-1-deficient	kinase-1-deficient	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	U4A	u4a	NN	NN	_	7	nsubj	_	_
7	expresses	express	VBZ	VBZ	_	0	root	_	_
8	HLA-DR	hla-dr	NN	NN	_	10	compound	_	_
9	alpha	alpha	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	16	case	_	_
12	response	response	NN	NN	_	16	dep	_	_
13	to	to	TO	TO	_	16	case	_	_
14	NK	nk	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	HLA-DR	hla-dr	NN	NN	_	22	compound	_	_
20	alpha	alpha	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	28	nsubjpass	_	_
23	transfected	transfect	VBN	VBN	_	22	acl	_	_
24	into	into	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	are	be	VBP	VBP	_	28	auxpass	_	_
28	induced	induce	VBN	VBN	_	7	conj	_	_
29	by	by	IN	IN	_	31	case	_	_
30	NK	nk	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	31	cc	_	_
34	IFN-gamma	ifn-gamma	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IFN-gamma-independent	ifn-gamma-independent	JJ	JJ	_	7	amod	_	_
7	component	component	NN	NN	_	18	nsubj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	target	target	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	HLA-DR	hla-dr	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	7	nmod	_	_
14	induced	induce	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	adhesion	adhesion	NN	NN	_	14	nmod	_	_
18	uses	use	VBZ	VBZ	_	3	ccomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	signaling	signaling	NN	NN	_	21	compound	_	_
21	pathway	pathway	NN	NN	_	18	dobj	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	distinct	distinct	JJ	JJ	_	21	acl:relcl	_	_
25	from	from	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	IFN-gamma-dependent	ifn-gamma-dependent	JJ	JJ	_	28	amod	_	_
28	mechanism	mechanism	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	3	cc	_	_
30	also	also	RB	RB	_	3	advmod	_	_
31	suggest	suggest	VBP	VBP	_	3	dep	_	_
32	that	that	IN	IN	_	36	mark	_	_
33	CIITA	ciita	NN	NN	_	36	nsubjpass	_	_
34	is	be	VBD	VBD	_	36	auxpass	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	required	require	VBN	VBN	_	31	ccomp	_	_
37	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	CD28-associated	cd28-associated	JJ	JJ	_	4	amod	_	_
3	signaling	signaling	NN	NN	_	4	compound	_	_
4	pathway	pathway	NN	NN	_	0	root	_	_
5	leading	lead	VBG	VBG	_	4	acl	_	_
6	to	to	TO	TO	_	9	case	_	_
7	cytokine	cytokine	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	9	conj	_	_
14	without	without	IN	IN	_	16	case	_	_
15	TCR	tcr	NN	NN	_	16	compound	_	_
16	engagement	engagement	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	resting	rest	VBG	VBG	_	6	amod	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	CD28-specific	cd28-specific	JJ	JJ	_	11	amod	_	_
10	mAb	mab	NN	NN	_	11	compound	_	_
11	BW	bw	NN	NN	_	6	nmod	_	_
12	828	828	CD	CD	_	11	nummod	_	_
13	induces	induce	VBZ	VBZ	_	0	root	_	_
14	proliferation	proliferation	NN	NN	_	13	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cytokine	cytokine	NN	NN	_	17	compound	_	_
17	synthesis	synthesis	NN	NN	_	14	conj	_	_
18	without	without	IN	IN	_	20	case	_	_
19	further	further	JJ	JJ	_	20	amod	_	_
20	requirement	requirement	NN	NN	_	13	nmod	_	_
21	for	for	IN	IN	_	23	case	_	_
22	TCR	tcr	NN	NN	_	23	compound	_	_
23	coengagement	coengagement	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	3	nsubj	_	_
3	prompted	prompt	VBD	VBD	_	0	root	_	_
4	us	we	PRP	PRP	_	3	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	postulate	postulate	VB	VB	_	3	advcl	_	_
7	that	that	IN	IN	_	23	mark	_	_
8	signal	signal	NN	NN	_	23	nsubj	_	_
9	2	2	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	costimulatory	costimulatory	JJ	JJ	_	12	amod	_	_
12	signal	signal	NN	NN	_	8	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	alone	alone	RB	RB	_	8	amod	_	_
15	without	without	IN	IN	_	16	case	_	_
16	signal	signal	NN	NN	_	8	nmod	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	TCR	tcr	NN	NN	_	20	compound	_	_
20	signal	signal	NN	NN	_	16	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	activate	activate	VB	VB	_	6	ccomp	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	23	dobj	_	_
26	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	18	advcl	_	_
3	whether	whether	IN	IN	_	10	mark	_	_
4	this	this	DT	DT	_	6	det	_	_
5	putative	putative	JJ	JJ	_	6	amod	_	_
6	function	function	NN	NN	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CD28	cd28	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
11	via	via	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	particular	particular	JJ	JJ	_	15	amod	_	_
14	signaling	signaling	NN	NN	_	15	compound	_	_
15	pathway	pathway	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	compared	compare	VBD	VBD	_	0	root	_	_
19	early	early	JJ	JJ	_	21	amod	_	_
20	signaling	signaling	NN	NN	_	21	compound	_	_
21	events	event	NNS	NNS	_	18	dobj	_	_
22	initiated	initiate	VBN	VBN	_	21	acl	_	_
23	in	in	IN	IN	_	26	case	_	_
24	resting	rest	VBG	VBG	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	by	by	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	stimulatory	stimulatory	JJ	JJ	_	31	amod	_	_
30	mAb	mab	NN	NN	_	31	compound	_	_
31	BW	bw	NN	NN	_	22	nmod	_	_
32	828	828	CD	CD	_	31	nummod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	signals	signal	NNS	NNS	_	18	nmod	_	_
35	triggered	trigger	VBN	VBN	_	34	acl	_	_
36	by	by	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	nonstimulating	nonstimulating	JJ	JJ	_	40	amod	_	_
39	CD28	cd28	NN	NN	_	40	compound	_	_
40	mAb	mab	NN	NN	_	35	nmod	_	_
41	9.3	9.3	CD	CD	_	40	nummod	_	_
42	.	.	.	.	_	18	punct	_	_

1	Stimulation	stimulation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	BW	bw	NN	NN	_	4	nmod	_	_
7	828	828	CD	CD	_	6	nummod	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
13	Ca2+	ca2+	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	but	but	CC	CC	_	8	cc	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	lead	lead	VB	VB	_	8	conj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	detectable	detectable	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	kinases	kinase	NNS	NNS	_	21	nmod	_	_
26	p56(lck)	p56(lck)	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	c-Raf-1	c-raf-1	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pathway	pathway	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	induction	induction	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	6	nmod	_	_
11	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	NF-AT	nf-at	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	proteins	protein	NNS	NNS	_	12	conj	_	_
18	binding	bind	VBG	VBG	_	17	acl	_	_
19	to	to	TO	TO	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	CD28	cd28	NN	NN	_	23	compound	_	_
22	response	response	NN	NN	_	23	compound	_	_
23	element	element	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IL-2	il-2	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	stimulation	stimulation	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	mAb	mab	NN	NN	_	9	nmod	_	_
12	9.3	9.3	CD	CD	_	11	nummod	_	_
13	increased	increase	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	level	level	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	Ca2+	ca2+	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	triggered	trigger	VBD	VBD	_	13	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activation	activation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p56(lck)	p56(lck)	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	c-Raf-1	c-raf-1	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	13	punct	_	_
28	but	but	CC	CC	_	13	cc	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	unable	unable	JJ	JJ	_	13	conj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	induce	induce	VB	VB	_	30	xcomp	_	_
33	the	the	DT	DT	_	34	det	_	_
34	binding	binding	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	transcription	transcription	NN	NN	_	37	compound	_	_
37	factors	factor	NNS	NNS	_	34	nmod	_	_
38	to	to	TO	TO	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	IL-2	il-2	NN	NN	_	41	compound	_	_
41	promoter	promoter	NN	NN	_	34	nmod	_	_
42	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	differential	differential	JJ	JJ	_	6	amod	_	_
6	signaling	signaling	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	BW	bw	NN	NN	_	6	nmod	_	_
9	828	828	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	9.3	9.3	CD	CD	_	8	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	resting	rest	VBG	VBG	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	mAbs	mab	NNS	NNS	_	20	nsubj	_	_
20	exhibited	exhibit	VBD	VBD	_	0	root	_	_
21	a	a	DT	DT	_	23	det	_	_
22	similar	similar	JJ	JJ	_	23	amod	_	_
23	pattern	pattern	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	early	early	JJ	JJ	_	27	amod	_	_
26	signaling	signaling	NN	NN	_	27	compound	_	_
27	events	event	NNS	NNS	_	23	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	activated	activate	VBN	VBN	_	31	amod	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	Jurkat	jurkat	NN	NN	_	37	compound	_	_
34	cells	cell	NNS	NNS	_	37	compound	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	p56(lck)	p56(lck)	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	31	conj	_	_
38	,	,	,	,	_	37	punct	_	_
39	association	association	NN	NN	_	37	appos	_	_
40	of	of	IN	IN	_	42	case	_	_
41	phosphatidylinositol	phosphatidylinositol	NN	NN	_	42	compound	_	_
42	3-kinase	3-kinase	NN	NN	_	39	nmod	_	_
43	with	with	IN	IN	_	44	case	_	_
44	CD28	cd28	NN	NN	_	39	nmod	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	,	,	,	,	_	20	punct	_	_
47	indicating	indicate	VBG	VBG	_	20	advcl	_	_
48	that	that	IN	IN	_	54	mark	_	_
49	the	the	DT	DT	_	51	det	_	_
50	signaling	signaling	NN	NN	_	51	compound	_	_
51	capacity	capacity	NN	NN	_	54	nsubj	_	_
52	of	of	IN	IN	_	53	case	_	_
53	CD28	cd28	NN	NN	_	51	nmod	_	_
54	changes	change	VBZ	VBZ	_	47	ccomp	_	_
55	with	with	IN	IN	_	56	case	_	_
56	activation	activation	NN	NN	_	54	nmod	_	_
57	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	view	view	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	stimulation	stimulation	NN	NN	_	11	nsubj	_	_
8	through	through	IN	IN	_	9	case	_	_
9	CD28	cd28	NN	NN	_	7	nmod	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	induce	induce	VB	VB	_	5	dep	_	_
12	some	some	DT	DT	_	14	det	_	_
13	effector	effector	NN	NN	_	14	compound	_	_
14	functions	function	NNS	NNS	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	suggest	suggest	VBP	VBP	_	3	conj	_	_
20	that	that	IN	IN	_	24	mark	_	_
21	this	this	DT	DT	_	22	det	_	_
22	capacity	capacity	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	associated	associate	VBN	VBN	_	19	ccomp	_	_
25	with	with	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	particular	particular	JJ	JJ	_	28	amod	_	_
28	pattern	pattern	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	early	early	JJ	JJ	_	32	amod	_	_
31	signaling	signaling	NN	NN	_	32	compound	_	_
32	events	event	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Cyclosporin	cyclosporin	NN	NN	_	3	compound	_	_
2	A-resistant	a-resistant	JJ	JJ	_	3	amod	_	_
3	transactivation	transactivation	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	activity	activity	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	okadaic	okadaic	JJ	JJ	_	14	amod	_	_
12	acid-sensitive	acid-sensitive	JJ	JJ	_	14	amod	_	_
13	serine/threonine	serine/threonine	NN	NN	_	14	compound	_	_
14	phosphatases	phosphatase	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Expression	expression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	1	nmod	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	activation	activation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	through	through	IN	IN	_	12	case	_	_
12	stimulation	stimulation	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	TCR	tcr	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	costimulation	costimulation	NN	NN	_	7	conj	_	_
18	through	through	IN	IN	_	20	case	_	_
19	accessory	accessory	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	recently	recently	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	okadaic	okadaic	JJ	JJ	_	9	amod	_	_
7	acid-sensitive	acid-sensitive	JJ	JJ	_	9	amod	_	_
8	Ser/Thr	ser/thr	NN	NN	_	9	compound	_	_
9	phosphatases	phosphatase	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	involved	involve	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	cyclosporin	cyclosporin	NN	NN	_	16	compound	_	_
15	A-insensitive	a-insensitive	JJ	JJ	_	16	amod	_	_
16	pathway	pathway	NN	NN	_	11	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	selectively	selectively	RB	RB	_	19	advmod	_	_
19	transmits	transmit	VBZ	VBZ	_	16	acl:relcl	_	_
20	costimulatory	costimulatory	JJ	JJ	_	21	amod	_	_
21	signals	signal	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	analyzed	analyze	VBD	VBD	_	0	root	_	_
7	whether	whether	IN	IN	_	13	mark	_	_
8	activities	activity	NNS	NNS	_	13	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	phosphatases	phosphatase	NNS	NNS	_	8	nmod	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	necessary	necessary	JJ	JJ	_	6	ccomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	both	both	CC	CC	_	7	cc:preconj	_	_
3	activated	activate	VBN	VBN	_	7	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	activated	activate	VBN	VBN	_	13	amod	_	_
10	tumorigenic	tumorigenic	JJ	JJ	_	13	amod	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	7	conj	_	_
14	,	,	,	,	_	19	punct	_	_
15	IL-2	il-2	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	blocked	block	VBN	VBN	_	0	root	_	_
20	at	at	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	level	level	NN	NN	_	19	nmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	okadaic	okadaic	JJ	JJ	_	26	amod	_	_
26	acid	acid	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	11	nsubjpass	_	_
4	active	active	JJ	JJ	_	3	amod	_	_
5	at	at	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	were	be	VBD	VBD	_	11	auxpass	_	_
10	differentially	differentially	RB	RB	_	11	advmod	_	_
11	influenced	influence	VBN	VBN	_	0	root	_	_
12	:	:	:	:	_	11	punct	_	_
13	upon	upon	IN	IN	_	14	case	_	_
14	down-modulation	down-modulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	okadaic	okadaic	JJ	JJ	_	18	amod	_	_
17	acid-sensitive	acid-sensitive	JJ	JJ	_	18	amod	_	_
18	phosphatases	phosphatase	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	transactivation	transactivation	NN	NN	_	14	appos	_	_
21	by	by	IN	IN	_	25	case	_	_
22	octamer	octamer	NN	NN	_	25	compound	_	_
23	,	,	,	,	_	25	punct	_	_
24	NF-kappa	nf-kappa	NN	NN	_	25	dep	_	_
25	B	b	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	11	punct	_	_
27	and	and	CC	CC	_	11	cc	_	_
28	NF	nf	NN	NN	_	33	compound	_	_
29	of	of	IN	IN	_	33	amod	_	_
30	activated	activate	VBN	VBN	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cells	cell	NNS	NNS	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	35	nsubjpass	_	_
34	was	be	VBD	VBD	_	35	auxpass	_	_
35	abrogated	abrogate	VBN	VBN	_	11	conj	_	_
36	,	,	,	,	_	35	punct	_	_
37	while	while	IN	IN	_	44	mark	_	_
38	transactivation	transactivation	NN	NN	_	44	nsubjpass	_	_
39	by	by	IN	IN	_	41	case	_	_
40	AP-1	ap-1	NN	NN	_	41	compound	_	_
41	proteins	protein	NNS	NNS	_	38	nmod	_	_
42	was	be	VBD	VBD	_	44	auxpass	_	_
43	even	even	RB	RB	_	44	advmod	_	_
44	enhanced	enhance	VBN	VBN	_	35	advcl	_	_
45	.	.	.	.	_	11	punct	_	_

1	Inducible	inducible	JJ	JJ	_	3	amod	_	_
2	nitric	nitric	JJ	JJ	_	3	amod	_	_
3	oxide	oxide	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	an	a	DT	DT	_	8	det	_	_
6	autoregulatory	autoregulatory	JJ	JJ	_	8	amod	_	_
7	feedback	feedback	NN	NN	_	8	compound	_	_
8	inhibitor	inhibitor	NN	NN	_	3	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	vascular	vascular	JJ	JJ	_	11	amod	_	_
11	inflammation	inflammation	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Inducible	inducible	JJ	JJ	_	3	amod	_	_
2	nitric	nitric	JJ	JJ	_	3	amod	_	_
3	oxide	oxide	NN	NN	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	iNO	ino	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	produced	produce	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	10	case	_	_
10	sites	site	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	vascular	vascular	JJ	JJ	_	13	amod	_	_
13	inflammation	inflammation	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	20	case	_	_
15	resident	resident	JJ	JJ	_	20	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	nonresident	nonresident	JJ	JJ	_	15	conj	_	_
18	vascular	vascular	JJ	JJ	_	20	amod	_	_
19	wall	wall	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	8	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	but	but	CC	CC	_	8	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	role	role	NN	NN	_	31	nsubjpass	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	inflammatory	inflammatory	JJ	JJ	_	28	amod	_	_
28	process	process	NN	NN	_	24	nmod	_	_
29	is	be	VBZ	VBZ	_	31	auxpass	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	known	know	VBN	VBN	_	8	conj	_	_
32	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	function	function	NN	NN	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	iNO	ino	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	6	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	terminate	terminate	VB	VB	_	13	xcomp	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	processes	process	NNS	NNS	_	15	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	iNO	ino	NN	NN	_	14	nsubj	_	_
5	produced	produce	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	murine	murine	JJ	JJ	_	9	amod	_	_
8	macrophage-like	macrophage-like	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	RAW264.7	raw264.7	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	14	punct	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
15	cytokine-induced	cytokine-induced	JJ	JJ	_	18	amod	_	_
16	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	14	dobj	_	_
19	in	in	IN	IN	_	26	case	_	_
20	a	a	DT	DT	_	26	det	_	_
21	separated	separated	JJ	JJ	_	26	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	mixed	mixed	JJ	JJ	_	21	conj	_	_
24	endothelial-RAW264.7	endothelial-raw264.7	NN	NN	_	26	compound	_	_
25	coculture	coculture	NN	NN	_	26	compound	_	_
26	system	system	NN	NN	_	14	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	iNO	ino	NN	NN	_	3	compound	_	_
3	production	production	NN	NN	_	9	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
6	VCAM-1	vcam-1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	simultaneously	simultaneously	RB	RB	_	9	advmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	bacterial	bacterial	JJ	JJ	_	13	amod	_	_
13	LPS	lps	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	murine-specific	murine-specific	JJ	JJ	_	16	amod	_	_
16	IFN-gamma	ifn-gamma	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	Inhibition	inhibition	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	iNO	ino	NN	NN	_	4	compound	_	_
4	synthase	synthase	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	iNOS	inos	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	activity	activity	NN	NN	_	1	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	N	n	NN	NN	_	11	compound	_	_
11	omega-monomethyl-L-arginine	omega-monomethyl-l-arginine	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	endothelial-RAW264.7	endothelial-raw264.7	NN	NN	_	14	compound	_	_
14	cocultures	coculture	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	16	punct	_	_
16	stimulated	stimulate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	murine-specific	murine-specific	JJ	JJ	_	19	amod	_	_
19	IFN-gamma	ifn-gamma	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	LPS	lps	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	16	punct	_	_
23	decreased	decrease	VBD	VBD	_	16	conj	_	_
24	iNO	ino	NN	NN	_	25	compound	_	_
25	production	production	NN	NN	_	23	dobj	_	_
26	by	by	IN	IN	_	28	case	_	_
27	86	86	CD	CD	_	28	nummod	_	_
28	%	%	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	16	punct	_	_
30	augmented	augment	VBD	VBD	_	16	conj	_	_
31	VCAM-1	vcam-1	NN	NN	_	30	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	iNOS	inos	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	conj	_	_
35	in	in	IN	IN	_	36	case	_	_
36	endothelial	endothelial	JJ	JJ	_	30	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	RAW264.7	raw264.7	NN	NN	_	36	conj	_	_
39	cells	cell	NNS	NNS	_	36	dep	_	_
40	,	,	,	,	_	30	punct	_	_
41	respectively	respectively	RB	RB	_	30	advmod	_	_
42	,	,	,	,	_	16	punct	_	_
43	and	and	CC	CC	_	16	cc	_	_
44	increased	increase	VBD	VBD	_	16	conj	_	_
45	monocyte	monocyte	NN	NN	_	46	compound	_	_
46	adhesion	adhesion	NN	NN	_	44	dobj	_	_
47	to	to	TO	TO	_	51	case	_	_
48	the	the	DT	DT	_	51	det	_	_
49	endothelial	endothelial	JJ	JJ	_	51	amod	_	_
50	cell	cell	NN	NN	_	51	compound	_	_
51	surface	surface	NN	NN	_	46	nmod	_	_
52	.	.	.	.	_	16	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	9	nsubj	_	_
4	using	use	VBG	VBG	_	3	acl	_	_
5	various	various	JJ	JJ	_	8	amod	_	_
6	VCAM-1	vcam-1	NN	NN	_	8	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	constructs	construct	NNS	NNS	_	4	dobj	_	_
9	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	20	mark	_	_
11	inhibitory	inhibitory	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	20	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	iNO	ino	NN	NN	_	12	nmod	_	_
15	on	on	IN	IN	_	16	case	_	_
16	VCAM-1	vcam-1	NN	NN	_	12	nmod	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	16	dep	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	mediated	mediate	VBN	VBN	_	9	ccomp	_	_
21	,	,	,	,	_	20	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	part	part	NN	NN	_	20	advmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	by	by	IN	IN	_	27	case	_	_
26	inhibitory	inhibitory	JJ	JJ	_	27	amod	_	_
27	effects	effect	NNS	NNS	_	20	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	iNO	ino	NN	NN	_	27	nmod	_	_
30	on	on	IN	IN	_	34	case	_	_
31	kappa	kappa	NN	NN	_	34	compound	_	_
32	B	b	NN	NN	_	34	compound	_	_
33	cis-acting	cis-acting	JJ	JJ	_	34	amod	_	_
34	elements	element	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	Immunofluorescence	immunofluorescence	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	17	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	an	a	DT	DT	_	5	det	_	_
5	Ab	ab	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	RelA	rela	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	p65	p65	NN	NN	_	12	compound	_	_
11	)	)	-RRB-	-RRB-	_	12	punct	_	_
12	subunit	subunit	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	factor-kappa	factor-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	12	nmod	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	iNO	ino	NN	NN	_	20	nsubj	_	_
20	inhibited	inhibit	VBD	VBD	_	17	ccomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	activation	activation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
25	factor-kappa	factor-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	iNO	ino	NN	NN	_	6	nsubj	_	_
6	attenuates	attenuate	VBZ	VBZ	_	3	ccomp	_	_
7	iNOS	inos	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	inhibits	inhibit	VBZ	VBZ	_	6	conj	_	_
13	monocyte	monocyte	NN	NN	_	14	compound	_	_
14	adhesion	adhesion	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	endothelial	endothelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	suggest	suggest	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	30	mark	_	_
22	endogenously	endogenously	RB	RB	_	23	advmod	_	_
23	derived	derive	VBN	VBN	_	24	amod	_	_
24	iNO	ino	NN	NN	_	30	nsubj	_	_
25	may	may	MD	MD	_	30	aux	_	_
26	be	be	VB	VB	_	30	cop	_	_
27	an	a	DT	DT	_	30	det	_	_
28	important	important	JJ	JJ	_	30	amod	_	_
29	autoregulatory	autoregulatory	JJ	JJ	_	30	amod	_	_
30	inhibitor	inhibitor	NN	NN	_	20	ccomp	_	_
31	of	of	IN	IN	_	33	case	_	_
32	vascular	vascular	JJ	JJ	_	33	amod	_	_
33	inflammation	inflammation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	peroxisome	peroxisome	NN	NN	_	5	compound	_	_
3	proliferator-activated	proliferator-activated	JJ	JJ	_	5	amod	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	alpha	alpha	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PPARalpha	pparalpha	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	ligand	ligand	NN	NN	_	14	nsubj	_	_
10	WY	wy	NN	NN	_	9	dep	_	_
11	14,643	14,643	CD	CD	_	10	nummod	_	_
12	does	do	VBZ	VBZ	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	interfere	interfere	VB	VB	_	0	root	_	_
15	with	with	IN	IN	_	19	case	_	_
16	leukotriene	leukotriene	NN	NN	_	19	compound	_	_
17	B4	b4	NN	NN	_	19	compound	_	_
18	induced	induced	JJ	JJ	_	19	amod	_	_
19	adhesion	adhesion	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	neutrophils	neutrophil	NNS	NNS	_	19	acl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	endothelial	endothelial	JJ	JJ	_	24	case	_	_
24	cells	cell	NNS	NNS	_	19	acl	_	_
25	.	.	.	.	_	14	punct	_	_

1	Peroxisome	peroxisome	NN	NN	_	3	compound	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	3	amod	_	_
3	receptors	receptor	NNS	NNS	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PPAR	ppar	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	control	control	VBP	VBP	_	0	root	_	_
8	discrete	discrete	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	7	dobj	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	fatty	fatty	JJ	JJ	_	13	amod	_	_
13	acid	acid	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	lipid	lipid	NN	NN	_	16	compound	_	_
16	metabolism	metabolism	NN	NN	_	13	conj	_	_
17	.	.	.	.	_	7	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	suggested	suggest	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	24	mark	_	_
7	activation	activation	NN	NN	_	24	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	isoform	isoform	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PPAR	ppar	NNS	NNS	_	11	nmod	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	potent	potent	JJ	JJ	_	18	amod	_	_
17	proinflammatory	proinflammatory	JJ	JJ	_	18	amod	_	_
18	mediator	mediator	NN	NN	_	7	nmod	_	_
19	leukotriene	leukotriene	NN	NN	_	20	compound	_	_
20	B4	b4	NN	NN	_	18	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	LTB4	ltb4	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	enhanced	enhance	VBD	VBD	_	5	ccomp	_	_
25	degradation	degradation	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	eicosanoid	eicosanoid	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	offersuggesting	offersuggest	VBG	VBG	_	24	advcl	_	_
31	a	a	DT	DT	_	33	det	_	_
32	new	new	JJ	JJ	_	33	amod	_	_
33	aspect	aspect	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	down-regulation	down-regulation	NN	NN	_	37	compound	_	_
36	of	of	IN	IN	_	37	amod	_	_
37	inflammation	inflammation	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	30	mark	_	_
6	PPARalpha	pparalpha	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	30	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	by	by	IN	IN	_	10	case	_	_
10	means	means	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	selective	selective	JJ	JJ	_	14	amod	_	_
14	agonist	agonist	NN	NN	_	10	nmod	_	_
15	WY	wy	NN	NN	_	14	dep	_	_
16	14,643	14,643	CD	CD	_	15	nummod	_	_
17	)	)	-RRB-	-RRB-	_	10	punct	_	_
18	of	of	IN	IN	_	20	case	_	_
19	endothelial	endothelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	7	nmod	_	_
21	,	,	,	,	_	7	punct	_	_
22	pivotal	pivotal	JJ	JJ	_	7	amod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	regulation	regulation	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	inflammatory	inflammatory	JJ	JJ	_	28	amod	_	_
28	responses	response	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	30	punct	_	_
30	interfered	interfere	VBN	VBN	_	4	ccomp	_	_
31	with	with	IN	IN	_	34	case	_	_
32	LTB4	ltb4	NN	NN	_	34	compound	_	_
33	induced	induce	VBD	VBD	_	34	amod	_	_
34	adhesion	adhesion	NN	NN	_	30	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	PMN	pmn	NN	NN	_	38	compound	_	_
37	neutrophil	neutrophil	NN	NN	_	38	compound	_	_
38	granulocytes	granulocyte	NNS	NNS	_	34	nmod	_	_
39	in	in	FW	FW	_	40	compound	_	_
40	vitro	vitro	FW	FW	_	30	advmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	endothelial	endothelial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	treated	treat	VBN	VBN	_	28	advcl	_	_
6	with	with	IN	IN	_	7	case	_	_
7	WY	wy	NN	NN	_	5	nmod	_	_
8	14,643	14,643	CD	CD	_	7	nummod	_	_
9	prior	prior	RB	RB	_	7	amod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	LTB4	ltb4	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	or	or	CC	CC	_	16	cc	_	_
16	fMLP	fmlp	NN	NN	_	13	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	IL-1beta	il-1beta	NN	NN	_	16	conj	_	_
19	or	or	CC	CC	_	16	cc	_	_
20	TNFalpha	tnfalpha	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	as	as	IN	IN	_	23	case	_	_
23	controls	control	NNS	NNS	_	16	nmod	_	_
24	)	)	-RRB-	-RRB-	_	16	punct	_	_
25	we	we	PRP	PRP	_	28	nsubj	_	_
26	could	could	MD	MD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	document	document	VB	VB	_	0	root	_	_
29	any	any	DT	DT	_	30	det	_	_
30	effect	effect	NN	NN	_	28	dobj	_	_
31	on	on	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	number	number	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	adhering	adhering	JJ	JJ	_	36	amod	_	_
36	PMN	pmn	NN	NN	_	33	nmod	_	_
37	or	or	CC	CC	_	33	cc	_	_
38	duration	duration	NN	NN	_	33	conj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	response	response	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	28	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	5	nsubj	_	_
5	provides	provide	VBZ	VBZ	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	evidence	evidence	NN	NN	_	5	dobj	_	_
8	indicating	indicate	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	11	det	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	function	function	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PPARalpha	pparalpha	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	LTB4	ltb4	NN	NN	_	18	compound	_	_
16	induced	induced	JJ	JJ	_	18	amod	_	_
17	adhesive	adhesive	JJ	JJ	_	18	amod	_	_
18	interactions	interaction	NNS	NNS	_	13	nmod	_	_
19	between	between	IN	IN	_	21	case	_	_
20	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	neutrophils	neutrophil	NNS	NNS	_	21	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	B	b	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	T	t	NN	NN	_	3	conj	_	_
6	cells	cell	NNS	NNS	_	3	dep	_	_
7	activates	activate	VBZ	VBZ	_	0	root	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	differentiation	differentiation	NN	NN	_	10	conj	_	_
13	factors	factor	NNS	NNS	_	10	dep	_	_
14	.	.	.	.	_	7	punct	_	_

1	During	during	IN	IN	_	2	case	_	_
2	B	b	NN	NN	_	12	nmod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	T	t	NN	NN	_	2	conj	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	differentiation	differentiation	NN	NN	_	2	dep	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	proliferation	proliferation	NN	NN	_	2	conj	_	_
9	many	many	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	repressed	repress	VBN	VBN	_	12	conj	_	_
15	while	while	IN	IN	_	20	mark	_	_
16	certain	certain	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	20	nsubjpass	_	_
18	are	be	VBP	VBP	_	20	auxpass	_	_
19	constitutively	constitutively	RB	RB	_	20	advmod	_	_
20	expressed	express	VBN	VBN	_	12	advcl	_	_
21	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	24	advcl	_	_
3	processes	process	NNS	NNS	_	2	dobj	_	_
4	related	related	JJ	JJ	_	3	dep	_	_
5	to	to	TO	TO	_	6	case	_	_
6	B	b	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	T	t	NN	NN	_	6	conj	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	dep	_	_
11	,	,	,	,	_	24	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	24	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	stimulated	stimulate	VBN	VBN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	nonstimulated	nonstimulated	JJ	JJ	_	16	conj	_	_
19	Ramos	ramos	NN	NN	_	16	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Jurkat	jurkat	NN	NN	_	19	conj	_	_
22	cells	cell	NNS	NNS	_	19	dep	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	studied	study	VBN	VBN	_	0	root	_	_
25	using	use	VBG	VBG	_	24	xcomp	_	_
26	cDNA	cdna	NN	NN	_	28	compound	_	_
27	microarray	microarray	NN	NN	_	28	compound	_	_
28	technology	technology	NN	NN	_	25	dobj	_	_
29	.	.	.	.	_	24	punct	_	_

1	Simultaneous	simultaneous	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	close	close	JJ	JJ	_	6	advmod	_	_
5	to	to	TO	TO	_	6	dep	_	_
6	600	600	CD	CD	_	7	nummod	_	_
7	genes	gene	NNS	NNS	_	2	nmod	_	_
8	indicated	indicate	VBD	VBD	_	0	root	_	_
9	highest	highest	JJS	JJS	_	10	amod	_	_
10	increase	increase	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	certain	certain	JJ	JJ	_	16	amod	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	differentiation	differentiation	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	proliferation	proliferation	NN	NN	_	16	conj	_	_
21	factors	factor	NNS	NNS	_	16	dep	_	_
22	.	.	.	.	_	8	punct	_	_

1	Many	many	JJ	JJ	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	have	have	VBP	VBP	_	9	aux	_	_
6	not	not	RB	RB	_	9	neg	_	_
7	previously	previously	RB	RB	_	9	advmod	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	funcion	funcion	VB	VB	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	stimulated	stimulate	VBN	VBN	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Also	also	RB	RB	_	16	advmod	_	_
2	genes	gene	NNS	NNS	_	4	compound	_	_
3	encoding	encode	VBG	VBG	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	16	nsubjpass	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	replication	replication	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	binding	binding	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	transcription	transcription	NN	NN	_	8	conj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	translation	translation	NN	NN	_	8	conj	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Large	large	JJ	JJ	_	2	amod	_	_
2	part	part	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	activated	activate	VBN	VBN	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	2	nmod	_	_
7	were	be	VBD	VBD	_	13	cop	_	_
8	under	under	IN	IN	_	11	case	_	_
9	very	very	RB	RB	_	10	advmod	_	_
10	stringent	stringent	JJ	JJ	_	11	amod	_	_
11	regulation	regulation	NN	NN	_	13	nmod	_	_
12	being	be	VBG	VBG	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	0	root	_	_
14	only	only	RB	RB	_	13	advcl	_	_
15	after	after	IN	IN	_	16	case	_	_
16	stimulation	stimulation	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	16	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	function	function	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	expressed	express	VBN	VBN	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	during	during	IN	IN	_	11	case	_	_
10	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	in	in	IN	IN	_	14	case	_	_
14	disorders	disorder	NNS	NNS	_	11	conj	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	discussed	discuss	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	cytokine	cytokine	NN	NN	_	5	compound	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	induction	induction	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT	stat	NN	NN	_	8	compound	_	_
8	complexes	complex	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	T	t	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NK	nk	NN	NN	_	12	conj	_	_
15	cells	cell	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	1	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	17	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	IL-2	il-2	NN	NN	_	1	appos	_	_
4	,	,	,	,	_	3	punct	_	_
5	IL-4	il-4	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	IL-6	il-6	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	IL-7	il-7	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	IL-12	il-12	NN	NN	_	3	conj	_	_
12	,	,	,	,	_	3	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	IL-15	il-15	NN	NN	_	3	conj	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	key	key	JJ	JJ	_	17	amod	_	_
17	regulators	regulator	NNS	NNS	_	0	root	_	_
18	of	of	IN	IN	_	25	case	_	_
19	human	human	JJ	JJ	_	25	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
21	blood	blood	NN	NN	_	25	compound	_	_
22	T	t	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	NK	nk	NN	NN	_	22	conj	_	_
25	cell	cell	NN	NN	_	17	nmod	_	_
26	activation	activation	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	differentiation	differentiation	NN	NN	_	26	conj	_	_
29	but	but	CC	CC	_	17	cc	_	_
30	the	the	DT	DT	_	32	det	_	_
31	precise	precise	JJ	JJ	_	32	amod	_	_
32	mechanisms	mechanism	NNS	NNS	_	45	nsubj	_	_
33	that	that	WDT	WDT	_	34	nsubj	_	_
34	give	give	VBP	VBP	_	32	acl:relcl	_	_
35	rise	rise	VBP	VBP	_	34	dobj	_	_
36	to	to	TO	TO	_	39	case	_	_
37	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
38	differential	differential	JJ	JJ	_	39	amod	_	_
39	activities	activity	NNS	NNS	_	35	nmod	_	_
40	within	within	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	are	be	VBP	VBP	_	45	cop	_	_
44	not	not	RB	RB	_	45	neg	_	_
45	clear	clear	JJ	JJ	_	17	conj	_	_
46	.	.	.	.	_	17	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	family	family	NN	NN	_	21	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	signal	signal	NN	NN	_	12	compound	_	_
12	transducers	transducer	NNS	NNS	_	9	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	activators	activator	NNS	NNS	_	16	compound	_	_
15	of	of	IN	IN	_	16	amod	_	_
16	transcription	transcription	NN	NN	_	12	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	STATs	stats	NNS	NNS	_	12	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	directly	directly	RB	RB	_	21	advmod	_	_
21	mediate	mediate	VB	VB	_	3	ccomp	_	_
22	many	many	JJ	JJ	_	24	amod	_	_
23	cytokine	cytokine	NN	NN	_	24	compound	_	_
24	signals	signal	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	activation	activation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STATs	stats	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	T	t	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NK	nk	NN	NN	_	10	conj	_	_
13	cells	cell	NNS	NNS	_	10	dep	_	_
14	by	by	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	variety	variety	NN	NN	_	2	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	specific	specific	JJ	JJ	_	19	amod	_	_
19	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	IL-12	il-12	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
6	STAT4	stat4	NN	NN	_	5	dobj	_	_
7	only	only	RB	RB	_	5	advcl	_	_
8	in	in	IN	IN	_	13	case	_	_
9	freshly	freshly	RB	RB	_	10	advmod	_	_
10	isolated	isolate	VBN	VBN	_	13	amod	_	_
11	primary	primary	JJ	JJ	_	13	amod	_	_
12	NK	nk	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	but	but	CC	CC	_	13	cc	_	_
16	not	not	RB	RB	_	20	neg	_	_
17	in	in	IN	IN	_	20	case	_	_
18	primary	primary	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	13	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	consistent	consistent	JJ	JJ	_	20	amod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	lack	lack	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IL-12	il-12	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	25	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	resting	rest	VBG	VBG	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IL-4	il-4	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	different	different	JJ	JJ	_	12	amod	_	_
7	C	c	NN	NN	_	12	compound	_	_
8	epsilon	epsilon	NN	NN	_	12	compound	_	_
9	GAS	gas	NN	NN	_	12	compound	_	_
10	DNA-protein	dna-protein	JJ	JJ	_	12	amod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	complexes	complex	NNS	NNS	_	5	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	T	t	NN	NN	_	5	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NK	nk	NN	NN	_	15	conj	_	_
18	cells	cell	NNS	NNS	_	15	dep	_	_
19	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	IL-4	il-4	NN	NN	_	4	compound	_	_
4	costimulation	costimulation	NN	NN	_	11	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IL-2	il-2	NN	NN	_	4	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	IL-12	il-12	NN	NN	_	6	conj	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	alter	alter	VB	VB	_	0	root	_	_
12	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
13	own	own	JJ	JJ	_	18	amod	_	_
14	preferential	preferential	JJ	JJ	_	18	amod	_	_
15	GAS-like	gas-like	JJ	JJ	_	18	amod	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	patterns	pattern	NNS	NNS	_	11	dobj	_	_
19	when	when	WRB	WRB	_	35	advmod	_	_
20	C	c	NN	NN	_	21	compound	_	_
21	epsilon-	epsilon-	NN	NN	_	35	nsubjpass	_	_
22	,	,	,	,	_	21	punct	_	_
23	Fc	fc	NN	NN	_	25	compound	_	_
24	gamma	gamma	NN	NN	_	25	compound	_	_
25	RI-	ri-	NN	NN	_	21	conj	_	_
26	,	,	,	,	_	21	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	SIE	sie	NN	NN	_	29	compound	_	_
29	GAS	gas	NN	NN	_	21	conj	_	_
30	motif	motif	NN	NN	_	21	dep	_	_
31	containing	contain	VBG	VBG	_	21	acl	_	_
32	oligonucleotide	oligonucleotide	NN	NN	_	33	compound	_	_
33	probes	probe	NNS	NNS	_	31	dobj	_	_
34	are	be	VBP	VBP	_	35	auxpass	_	_
35	compared	compare	VBN	VBN	_	11	dep	_	_
36	,	,	,	,	_	11	punct	_	_
37	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
38	that	that	IN	IN	_	54	mark	_	_
39	induction	induction	NN	NN	_	54	nsubj	_	_
40	of	of	IN	IN	_	44	case	_	_
41	GAS-like	gas-like	JJ	JJ	_	44	amod	_	_
42	DNA-protein	dna-protein	JJ	JJ	_	44	amod	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	complexes	complex	NNS	NNS	_	39	nmod	_	_
45	by	by	IN	IN	_	46	case	_	_
46	IL-2	il-2	NN	NN	_	39	nmod	_	_
47	,	,	,	,	_	46	punct	_	_
48	IL-4	il-4	NN	NN	_	46	conj	_	_
49	,	,	,	,	_	46	punct	_	_
50	and	and	CC	CC	_	46	cc	_	_
51	IL-12	il-12	NN	NN	_	46	conj	_	_
52	is	be	VBZ	VBZ	_	54	cop	_	_
53	highly	highly	RB	RB	_	54	advmod	_	_
54	selective	selective	JJ	JJ	_	37	ccomp	_	_
55	and	and	CC	CC	_	54	cc	_	_
56	represents	represent	VBZ	VBZ	_	54	conj	_	_
57	one	one	CD	CD	_	59	nummod	_	_
58	important	important	JJ	JJ	_	59	amod	_	_
59	factor	factor	NN	NN	_	56	dobj	_	_
60	in	in	IN	IN	_	61	mark	_	_
61	determining	determine	VBG	VBG	_	59	acl	_	_
62	specific	specific	JJ	JJ	_	64	amod	_	_
63	gene	gene	NN	NN	_	64	compound	_	_
64	activation	activation	NN	NN	_	61	dobj	_	_
65	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	IL-6	il-6	NN	NN	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-2	il-2	NN	NN	_	4	conj	_	_
7	synergistically	synergistically	RB	RB	_	8	advmod	_	_
8	induce	induce	VBP	VBP	_	0	root	_	_
9	homo-	homo-	JJ	JJ	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	heterodimerized	heterodimerized	JJ	JJ	_	9	conj	_	_
12	STAT1	stat1	NN	NN	_	13	compound	_	_
13	alpha	alpha	NN	NN	_	8	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	STAT3	stat3	NN	NN	_	13	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	NK	nk	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	T	t	NN	NN	_	18	conj	_	_
21	cells	cell	NNS	NNS	_	18	dep	_	_
22	,	,	,	,	_	13	punct	_	_
23	consistent	consistent	JJ	JJ	_	13	amod	_	_
24	with	with	IN	IN	_	27	case	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	reported	report	VBN	VBN	_	27	amod	_	_
27	synergism	synergism	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	29	mark	_	_
29	modulating	modulate	VBG	VBG	_	27	acl	_	_
30	perforin	perforin	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	IL-2	il-2	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	-7	-7	CD	CD	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	-15	-15	CD	CD	_	5	conj	_	_
11	induce	induce	VBP	VBP	_	3	ccomp	_	_
12	multiple	multiple	JJ	JJ	_	14	amod	_	_
13	STAT	stat	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	17	case	_	_
17	STAT5a	stat5a	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	STAT5b	stat5b	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	STAT1	stat1	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	17	conj	_	_
23	,	,	,	,	_	17	punct	_	_
24	STAT3	stat3	NN	NN	_	17	conj	_	_
25	,	,	,	,	_	17	punct	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	another	another	DT	DT	_	34	det	_	_
28	unidentified	unidentified	JJ	JJ	_	34	amod	_	_
29	Fc	fc	NN	NN	_	34	compound	_	_
30	gamma	gamma	NN	NN	_	34	compound	_	_
31	RI	ri	NN	NN	_	34	compound	_	_
32	GAS	gas	NN	NN	_	34	compound	_	_
33	DNA-binding	dna-binding	NN	NN	_	34	compound	_	_
34	protein	protein	NN	NN	_	17	conj	_	_
35	.	.	.	.	_	3	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observed	observe	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	STAT5a	stat5a	NN	NN	_	11	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	STAT5b	stat5b	NN	NN	_	7	conj	_	_
10	proteins	protein	NNS	NNS	_	7	dep	_	_
11	form	form	VBP	VBP	_	4	ccomp	_	_
12	distinct	distinct	JJ	JJ	_	18	amod	_	_
13	Fc	fc	NN	NN	_	18	compound	_	_
14	gamma	gamma	NN	NN	_	18	compound	_	_
15	RI	ri	NN	NN	_	18	compound	_	_
16	GAS	gas	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	patterns	pattern	NNS	NNS	_	11	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	T	t	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NK	nk	NN	NN	_	20	conj	_	_
23	cells	cell	NNS	NNS	_	20	dep	_	_
24	,	,	,	,	_	11	punct	_	_
25	suggesting	suggest	VBG	VBG	_	11	advcl	_	_
26	that	that	IN	IN	_	29	mark	_	_
27	they	they	PRP	PRP	_	29	nsubj	_	_
28	might	might	MD	MD	_	29	aux	_	_
29	have	have	VB	VB	_	25	ccomp	_	_
30	different	different	JJ	JJ	_	31	amod	_	_
31	roles	role	NNS	NNS	_	29	dobj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	regulation	regulation	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	32	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	differential	differential	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	32	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	conj	_	_
15	seen	see	VBN	VBN	_	11	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	primary	primary	JJ	JJ	_	18	amod	_	_
18	NK	nk	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	T	t	NN	NN	_	18	conj	_	_
21	cells	cell	NNS	NNS	_	18	dep	_	_
22	on	on	IN	IN	_	24	case	_	_
23	direct	direct	JJ	JJ	_	24	amod	_	_
24	stimulation	stimulation	NN	NN	_	8	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	different	different	JJ	JJ	_	27	amod	_	_
27	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
28	may	may	MD	MD	_	32	aux	_	_
29	be	be	VB	VB	_	32	cop	_	_
30	a	a	DT	DT	_	32	det	_	_
31	direct	direct	JJ	JJ	_	32	amod	_	_
32	result	result	NN	NN	_	4	dep	_	_
33	of	of	IN	IN	_	35	case	_	_
34	distinct	distinct	JJ	JJ	_	35	amod	_	_
35	activation	activation	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	STAT	stat	NN	NN	_	39	compound	_	_
38	transcription	transcription	NN	NN	_	39	compound	_	_
39	factors	factor	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HIV-1	hiv-1	NN	NN	_	4	compound	_	_
4	replication	replication	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	combination	combination	NN	NN	_	1	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	inhibitor	inhibitor	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	AZT	azt	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	small	small	JJ	JJ	_	4	amod	_	_
3	molecule	molecule	NN	NN	_	4	compound	_	_
4	S9a	s9a	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	derived	derive	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	16	case	_	_
8	an	a	DT	DT	_	16	det	_	_
9	established	established	JJ	JJ	_	16	amod	_	_
10	tumor	tumor	NN	NN	_	12	compound	_	_
11	necrosis	necrosis	NN	NN	_	12	compound	_	_
12	factor-alpha	factor-alpha	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	inhibitor	inhibitor	NN	NN	_	6	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Canventol	canventol	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	by	by	IN	IN	_	21	case	_	_
21	replacement	replacement	NN	NN	_	6	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	isopropylidine	isopropylidine	NN	NN	_	25	compound	_	_
25	group	group	NN	NN	_	21	nmod	_	_
26	with	with	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	phenyl	phenyl	NN	NN	_	29	compound	_	_
29	ring	ring	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	S9a	s9a	NN	NN	_	7	nsubj	_	_
2	at	at	IN	IN	_	6	case	_	_
3	10	10	CD	CD	_	5	compound	_	_
4	to	to	TO	TO	_	5	dep	_	_
5	100	100	CD	CD	_	6	nummod	_	_
6	nM	nm	NN	NN	_	1	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	HIV	hiv	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	as	as	RB	RB	_	11	advmod	_	_
11	potently	potently	RB	RB	_	7	advmod	_	_
12	as	as	IN	IN	_	13	case	_	_
13	3'-azido-3'-deoxythymidine	3'-azido-3'-deoxythymidine	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	AZT	azt	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	an	a	DT	DT	_	19	det	_	_
19	inhibitor	inhibitor	NN	NN	_	13	appos	_	_
20	of	of	IN	IN	_	23	case	_	_
21	viral	viral	JJ	JJ	_	23	amod	_	_
22	reverse	reverse	JJ	JJ	_	23	amod	_	_
23	transcriptase	transcriptase	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	S9a	s9a	NN	NN	_	13	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	AZT	azt	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	combination	combination	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	at	at	IN	IN	_	11	case	_	_
10	noncytoxic	noncytoxic	JJ	JJ	_	11	amod	_	_
11	concentrations	concentration	NNS	NNS	_	13	nmod	_	_
12	strongly	strongly	RB	RB	_	13	advmod	_	_
13	inhibited	inhibit	VBD	VBD	_	0	root	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	replication	replication	NN	NN	_	13	dobj	_	_
16	that	that	WDT	WDT	_	20	nsubj	_	_
17	was	be	VBD	VBD	_	20	cop	_	_
18	more	more	RBR	RBR	_	20	advmod	_	_
19	than	than	IN	IN	_	18	case	_	_
20	additive	additive	JJ	JJ	_	15	ccomp	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	substantially	substantially	RB	RB	_	23	advmod	_	_
23	prolonged	prolong	VBD	VBD	_	20	conj	_	_
24	the	the	DT	DT	_	25	det	_	_
25	appearance	appearance	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	virus	virus	NN	NN	_	25	nmod	_	_
28	both	both	CC	CC	_	33	cc:preconj	_	_
29	in	in	IN	IN	_	33	case	_	_
30	acutely	acutely	RB	RB	_	33	advmod	_	_
31	infected	infected	JJ	JJ	_	33	amod	_	_
32	CD4+	cd4+	JJ	JJ	_	33	amod	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	SupT	supt	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	in	in	IN	IN	_	38	case	_	_
38	culture	culture	NN	NN	_	33	nmod	_	_
39	and	and	CC	CC	_	33	cc	_	_
40	in	in	IN	IN	_	44	case	_	_
41	peripheral	peripheral	JJ	JJ	_	44	amod	_	_
42	blood	blood	NN	NN	_	44	compound	_	_
43	mononuclear	mononuclear	JJ	JJ	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	33	conj	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	PBMCs	pbmc	NNS	NNS	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	infected	infect	VBN	VBN	_	44	acl	_	_
49	with	with	IN	IN	_	53	case	_	_
50	a	a	DT	DT	_	53	det	_	_
51	primary	primary	JJ	JJ	_	53	amod	_	_
52	HIV-1	hiv-1	NN	NN	_	53	compound	_	_
53	isolate	isolate	NN	NN	_	48	nmod	_	_
54	.	.	.	.	_	13	punct	_	_

1	S9a	s9a	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	TNF-alpha	tnf-alpha	NN	NN	_	7	compound	_	_
4	promoter-driven	promoter-driven	JJ	JJ	_	7	amod	_	_
5	reporter	reporter	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	dobj	_	_
8	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	proposed	propose	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	antiviral	antiviral	JJ	JJ	_	9	amod	_	_
9	action	action	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	S9a	s9a	NN	NN	_	9	nmod	_	_
12	was	be	VBD	VBD	_	16	cop	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	host	host	NN	NN	_	16	compound	_	_
16	cell	cell	NN	NN	_	3	ccomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	blocking	block	VBG	VBG	_	16	advcl	_	_
20	TNF-alpha	tnf-alpha	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	19	dobj	_	_
22	via	via	IN	IN	_	26	case	_	_
23	a	a	DT	DT	_	26	det	_	_
24	Tat-induced	tat-induced	JJ	JJ	_	26	amod	_	_
25	tar-independent	tar-independent	JJ	JJ	_	26	amod	_	_
26	loop	loop	NN	NN	_	19	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	decreases	decrease	VBZ	VBZ	_	26	acl:relcl	_	_
30	downstream	downstream	JJ	JJ	_	32	amod	_	_
31	NF-kappaB	nf-kappab	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	29	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	HIV-1	hiv-1	NN	NN	_	37	compound	_	_
35	long	long	JJ	JJ	_	37	amod	_	_
36	terminal	terminal	JJ	JJ	_	37	amod	_	_
37	repeat	repeat	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	LTR	ltr	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	3	punct	_	_

1	S9a	s9a	NN	NN	_	3	nsubj	_	_
2	was	be	VBD	VBD	_	3	cop	_	_
3	superior	superior	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	first	first	JJ	JJ	_	7	amod	_	_
7	generation	generation	NN	NN	_	3	nmod	_	_
8	compound	compound	JJ	JJ	_	7	amod	_	_
9	Canventol	canventol	NN	NN	_	7	dep	_	_
10	,	,	,	,	_	7	punct	_	_
11	which	which	WDT	WDT	_	13	nsubj	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	superior	superior	JJ	JJ	_	7	acl:relcl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	natural	natural	JJ	JJ	_	17	amod	_	_
17	compound	compound	NN	NN	_	13	nmod	_	_
18	sarcophytol	sarcophytol	NN	NN	_	19	compound	_	_
19	A	a	NN	NN	_	17	dep	_	_
20	,	,	,	,	_	3	punct	_	_
21	demonstrating	demonstrate	VBG	VBG	_	3	dep	_	_
22	that	that	IN	IN	_	32	mark	_	_
23	further	further	JJ	JJ	_	25	amod	_	_
24	structure-based	structure-based	JJ	JJ	_	25	amod	_	_
25	enhancement	enhancement	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	potency	potency	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	compounds	compound	NNS	NNS	_	27	nmod	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	feasible	feasible	JJ	JJ	_	21	ccomp	_	_
33	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	therapeutic	therapeutic	JJ	JJ	_	6	amod	_	_
6	approach	approach	NN	NN	_	3	dobj	_	_
7	against	against	IN	IN	_	8	case	_	_
8	AIDS	aids	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	application	application	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	two	two	CD	CD	_	13	nummod	_	_
13	drugs	drug	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	one	one	CD	CD	_	13	appos	_	_
16	against	against	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	cellular	cellular	JJ	JJ	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	the	the	DT	DT	_	21	det	_	_
21	other	other	JJ	JJ	_	15	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	target	target	NN	NN	_	21	dep	_	_
25	,	,	,	,	_	6	punct	_	_
26	which	which	WDT	WDT	_	28	nsubj	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	provide	provide	VB	VB	_	6	acl:relcl	_	_
29	an	a	DT	DT	_	30	det	_	_
30	approach	approach	NN	NN	_	28	dobj	_	_
31	to	to	TO	TO	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	problem	problem	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	frequent	frequent	JJ	JJ	_	36	amod	_	_
36	emergence	emergence	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	resistant	resistant	JJ	JJ	_	39	amod	_	_
39	variants	variant	NNS	NNS	_	36	nmod	_	_
40	to	to	TO	TO	_	41	case	_	_
41	combinations	combination	NNS	NNS	_	39	nmod	_	_
42	of	of	IN	IN	_	43	case	_	_
43	drugs	drug	NNS	NNS	_	41	nmod	_	_
44	that	that	WDT	WDT	_	45	nsubj	_	_
45	target	target	VBP	VBP	_	43	acl:relcl	_	_
46	only	only	RB	RB	_	45	advmod	_	_
47	HIV	hiv	NN	NN	_	48	compound	_	_
48	genes	gene	NNS	NNS	_	45	dobj	_	_
49	.	.	.	.	_	3	punct	_	_

1	Specific	specific	JJ	JJ	_	3	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	different	different	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	motor	motor	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	number	number	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	dissociation	dissociation	NN	NN	_	10	compound	_	_
10	constant	constant	NN	NN	_	4	conj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	isolated	isolate	VBN	VBN	_	14	amod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
15	as	as	RB	RB	_	19	advmod	_	_
16	well	well	RB	RB	_	19	advmod	_	_
17	as	as	IN	IN	_	19	case	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	concentrations	concentration	NNS	NNS	_	4	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	hormones	hormone	NNS	NNS	_	19	nmod	_	_
22	produced	produce	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	hypothalamic-hypophyseal-adrenocortical	hypothalamic-hypophyseal-adrenocortical	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	three	three	CD	CD	_	30	nummod	_	_
29	experimental	experimental	JJ	JJ	_	30	amod	_	_
30	series	series	NNS	NNS	_	2	nmod	_	_
31	:	:	:	:	_	30	punct	_	_
32	at	at	IN	IN	_	62	case	_	_
33	normal	normal	JJ	JJ	_	62	amod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	17	17	CD	CD	_	36	nummod	_	_
36	subjects	subject	NNS	NNS	_	33	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	,	,	,	,	_	33	punct	_	_
39	decreased	decrease	VBN	VBN	_	33	conj	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	10	10	CD	CD	_	42	nummod	_	_
42	subjects	subject	NNS	NNS	_	39	dep	_	_
43	,	,	,	,	_	42	punct	_	_
44	a	a	DT	DT	_	48	det	_	_
45	360-d	360-d	JJ	JJ	_	48	amod	_	_
46	head-down	head-down	JJ	JJ	_	48	amod	_	_
47	bed	bed	NN	NN	_	48	compound	_	_
48	rest	rest	NN	NN	_	42	dep	_	_
49	)	)	-RRB-	-RRB-	_	42	punct	_	_
50	and	and	CC	CC	_	33	cc	_	_
51	increased	increase	VBN	VBN	_	33	conj	_	_
52	(	(	-LRB-	-LRB-	_	57	punct	_	_
53	8	8	CD	CD	_	57	dep	_	_
54	subjects	subject	NNS	NNS	_	57	dep	_	_
55	,	,	,	,	_	57	punct	_	_
56	physical	physical	JJ	JJ	_	57	amod	_	_
57	exercise	exercise	NN	NN	_	51	dep	_	_
58	on	on	IN	IN	_	60	case	_	_
59	bicycle	bicycle	NN	NN	_	60	compound	_	_
60	ergometer	ergometer	NN	NN	_	57	nmod	_	_
61	)	)	-RRB-	-RRB-	_	57	punct	_	_
62	levels	level	NNS	NNS	_	30	nmod	_	_
63	of	of	IN	IN	_	65	case	_	_
64	motor	motor	NN	NN	_	65	compound	_	_
65	activity	activity	NN	NN	_	62	nmod	_	_
66	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	first	first	JJ	JJ	_	4	amod	_	_
4	series	series	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	found	find	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	number	number	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	dissociation	dissociation	NN	NN	_	15	compound	_	_
15	constant	constant	NN	NN	_	12	conj	_	_
16	did	do	VBD	VBD	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	depend	depend	VB	VB	_	6	ccomp	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	season	season	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	on	on	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	age	age	NN	NN	_	21	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	subjects	subject	NNS	NNS	_	25	nmod	_	_
28	nor	nor	CC	CC	_	21	cc	_	_
29	on	on	IN	IN	_	31	case	_	_
30	cortisol	cortisol	NN	NN	_	31	compound	_	_
31	concentrations	concentration	NNS	NNS	_	21	conj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	blood	blood	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	second	second	JJ	JJ	_	4	amod	_	_
4	series	series	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	observed	observe	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	following	following	NN	NN	_	6	dobj	_	_
9	:	:	:	:	_	8	punct	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	end	end	NN	NN	_	29	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	first	first	JJ	JJ	_	16	amod	_	_
16	month	month	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	bed	bed	NN	NN	_	19	compound	_	_
19	rest	rest	NN	NN	_	16	nmod	_	_
20	the	the	DT	DT	_	21	det	_	_
21	number	number	NN	NN	_	29	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	receptor	receptor	NN	NN	_	27	compound	_	_
27	affinity	affinity	NN	NN	_	24	conj	_	_
28	significantly	significantly	RB	RB	_	29	advmod	_	_
29	increased	increase	VBD	VBD	_	8	dep	_	_
30	;	;	:	:	_	29	punct	_	_
31	at	at	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	beginning	beginning	NN	NN	_	45	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	third	third	JJ	JJ	_	37	amod	_	_
37	month	month	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	bed	bed	NN	NN	_	40	compound	_	_
40	rest	rest	NN	NN	_	37	nmod	_	_
41	specific	specific	JJ	JJ	_	43	amod	_	_
42	glucocorticoid	glucocorticoid	NN	NN	_	43	compound	_	_
43	binding	binding	NN	NN	_	45	nsubj	_	_
44	significantly	significantly	RB	RB	_	45	advmod	_	_
45	decreased	decrease	VBD	VBD	_	29	parataxis	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	circadian	circadian	JJ	JJ	_	48	amod	_	_
48	rhythms	rhythm	NNS	NNS	_	55	nsubj	_	_
49	of	of	IN	IN	_	50	case	_	_
50	adrenocorticotropin	adrenocorticotropin	NN	NN	_	48	nmod	_	_
51	and	and	CC	CC	_	50	cc	_	_
52	cortisol	cortisol	NN	NN	_	50	conj	_	_
53	in	in	IN	IN	_	54	case	_	_
54	blood	blood	NN	NN	_	52	acl	_	_
55	varied	vary	VBD	VBD	_	45	conj	_	_
56	markedly	markedly	RB	RB	_	55	advmod	_	_
57	;	;	:	:	_	29	punct	_	_
58	at	at	IN	IN	_	60	case	_	_
59	the	the	DT	DT	_	60	det	_	_
60	end	end	NN	NN	_	73	nmod	_	_
61	of	of	IN	IN	_	64	case	_	_
62	the	the	DT	DT	_	64	det	_	_
63	sixth	sixth	JJ	JJ	_	64	amod	_	_
64	month	month	NN	NN	_	60	nmod	_	_
65	of	of	IN	IN	_	67	case	_	_
66	bed	bed	NN	NN	_	67	compound	_	_
67	rest	rest	NN	NN	_	64	nmod	_	_
68	the	the	DT	DT	_	69	det	_	_
69	number	number	NN	NN	_	73	nsubj	_	_
70	of	of	IN	IN	_	72	case	_	_
71	glucocorticoid	glucocorticoid	NN	NN	_	72	dep	_	_
72	receptors	receptor	NNS	NNS	_	69	acl	_	_
73	returned	return	VBD	VBD	_	29	parataxis	_	_
74	to	to	TO	TO	_	77	case	_	_
75	prebed	prebed	JJ	JJ	_	77	amod	_	_
76	rest	rest	NN	NN	_	77	compound	_	_
77	levels	level	NNS	NNS	_	73	nmod	_	_
78	and	and	CC	CC	_	73	cc	_	_
79	dissociation	dissociation	NN	NN	_	80	compound	_	_
80	constant	constant	NN	NN	_	81	nsubj	_	_
81	decreased	decrease	VBD	VBD	_	73	conj	_	_
82	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	third	third	JJ	JJ	_	4	amod	_	_
4	series	series	NN	NN	_	31	nmod	_	_
5	physical	physical	JJ	JJ	_	6	amod	_	_
6	exercises	exercise	NNS	NNS	_	4	dep	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	induced	induce	VBD	VBD	_	31	csubj	_	_
9	an	a	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	hypothalamic-hypophyseal-adrenocortical	hypothalamic-hypophyseal-adrenocortical	JJ	JJ	_	14	amod	_	_
14	system	system	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	maximal	maximal	JJ	JJ	_	18	amod	_	_
17	physical	physical	JJ	JJ	_	18	amod	_	_
18	exercises	exercise	NNS	NNS	_	14	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	prolonged	prolonged	JJ	JJ	_	22	amod	_	_
21	submaximal	submaximal	JJ	JJ	_	22	amod	_	_
22	exercises	exercise	NNS	NNS	_	18	conj	_	_
23	at	at	IN	IN	_	25	case	_	_
24	70	70	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	maximal	maximal	JJ	JJ	_	29	amod	_	_
28	oxygen	oxygen	NN	NN	_	29	compound	_	_
29	uptake	uptake	NN	NN	_	25	nmod	_	_
30	)	)	-RRB-	-RRB-	_	18	punct	_	_
31	led	lead	VBD	VBD	_	0	root	_	_
32	to	to	TO	TO	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	significant	significant	JJ	JJ	_	35	amod	_	_
35	increase	increase	NN	NN	_	31	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	number	number	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	glucocorticoid	glucocorticoid	NN	NN	_	41	dep	_	_
41	receptors	receptor	NNS	NNS	_	38	acl	_	_
42	without	without	IN	IN	_	43	case	_	_
43	changes	change	NNS	NNS	_	31	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	dissociation	dissociation	NN	NN	_	46	compound	_	_
46	constant	constant	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	31	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	a	a	DT	DT	_	7	det	_	_
7	decrease	decrease	NN	NN	_	15	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	case	_	_
13	motor	motor	NN	NN	_	14	dep	_	_
14	activity	activity	NN	NN	_	7	acl	_	_
15	resulted	result	VBD	VBD	_	3	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	significant	significant	JJ	JJ	_	18	amod	_	_
18	changes	change	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	specific	specific	JJ	JJ	_	22	amod	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	18	nmod	_	_
23	which	which	WDT	WDT	_	26	nsubjpass	_	_
24	were	be	VBD	VBD	_	26	auxpass	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	influenced	influence	VBN	VBN	_	18	acl:relcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	changes	change	NNS	NNS	_	26	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	circulating	circulate	VBG	VBG	_	32	amod	_	_
31	hormone	hormone	NN	NN	_	32	compound	_	_
32	concentrations	concentration	NNS	NNS	_	28	nmod	_	_
33	in	in	IN	IN	_	34	case	_	_
34	blood	blood	NN	NN	_	32	nmod	_	_
35	but	but	CC	CC	_	28	cc	_	_
36	by	by	IN	IN	_	39	case	_	_
37	some	some	DT	DT	_	39	det	_	_
38	other	other	JJ	JJ	_	39	amod	_	_
39	factors	factor	NNS	NNS	_	28	conj	_	_
40	affected	affect	VBN	VBN	_	39	acl	_	_
41	by	by	IN	IN	_	43	case	_	_
42	physical	physical	JJ	JJ	_	43	case	_	_
43	activity	activity	NN	NN	_	40	advcl	_	_
44	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	CD40	cd40	NN	NN	_	3	dobj	_	_
5	+	+	CC	CC	_	4	cc	_	_
6	interleukin-4-mediated	interleukin-4-mediated	JJ	JJ	_	8	amod	_	_
7	IgE	ige	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	4	conj	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	3	advmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	elucidate	elucidate	VB	VB	_	31	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RA	ra	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	anti-CD40	anti-cd40	NN	NN	_	4	nmod	_	_
13	+	+	CC	CC	_	12	cc	_	_
14	interleukin-4	interleukin-4	NN	NN	_	20	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-4	il-4	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	-mediated	-mediated	JJ	JJ	_	20	amod	_	_
19	B-cell	b-cell	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	12	conj	_	_
21	,	,	,	,	_	31	punct	_	_
22	the	the	DT	DT	_	23	det	_	_
23	effect	effect	NN	NN	_	31	nsubjpass	_	_
24	of	of	IN	IN	_	29	case	_	_
25	10(-12)	10(-12)	CD	CD	_	27	compound	_	_
26	to	to	TO	TO	_	27	dep	_	_
27	10(-6)	10(-6)	CD	CD	_	29	nummod	_	_
28	mol/L	mol/l	NN	NN	_	29	compound	_	_
29	RA	ra	NN	NN	_	23	nmod	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	studied	study	VBN	VBN	_	0	root	_	_
32	in	in	IN	IN	_	33	case	_	_
33	anti-CD40	anti-cd40	NN	NN	_	31	nmod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	1	1	CD	CD	_	36	nummod	_	_
36	microgram/mL	microgram/ml	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	+	+	CC	CC	_	33	cc	_	_
39	IL-4	il-4	NN	NN	_	45	compound	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	5	5	CD	CD	_	42	nummod	_	_
42	ng/mL	ng/ml	NN	NN	_	39	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	-mediated	-mediated	JJ	JJ	_	45	amod	_	_
45	proliferation	proliferation	NN	NN	_	33	conj	_	_
46	and	and	CC	CC	_	33	cc	_	_
47	Ig	ig	NN	NN	_	48	compound	_	_
48	synthesis	synthesis	NN	NN	_	33	conj	_	_
49	by	by	IN	IN	_	54	case	_	_
50	human	human	JJ	JJ	_	54	amod	_	_
51	peripheral	peripheral	JJ	JJ	_	54	amod	_	_
52	blood	blood	NN	NN	_	54	compound	_	_
53	mononuclear	mononuclear	JJ	JJ	_	54	amod	_	_
54	cells	cell	NNS	NNS	_	31	nmod	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	PBMC	pbmc	NNS	NNS	_	54	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	and	and	CC	CC	_	54	cc	_	_
59	B	b	NN	NN	_	60	compound	_	_
60	cells	cell	NNS	NNS	_	54	conj	_	_
61	in	in	IN	IN	_	63	case	_	_
62	healthy	healthy	JJ	JJ	_	63	amod	_	_
63	donors	donor	NNS	NNS	_	54	nmod	_	_
64	.	.	.	.	_	31	punct	_	_

1	Anti-CD40	anti-cd40	NN	NN	_	4	compound	_	_
2	+	+	CC	CC	_	1	cc	_	_
3	IL-4-mediated	il-4-mediated	JJ	JJ	_	1	conj	_	_
4	proliferation	proliferation	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PBMC	pbmc	NNS	NNS	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	conj	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	RA	ra	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	dose-dependent	dose-dependent	JJ	JJ	_	17	amod	_	_
17	manner	manner	NN	NN	_	11	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	maximal	maximal	JJ	JJ	_	21	amod	_	_
21	inhibition	inhibition	NN	NN	_	11	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	62	62	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	21	nmod	_	_
25	+/-	+/-	CC	CC	_	24	cc	_	_
26	5	5	CD	CD	_	27	nummod	_	_
27	%	%	NN	NN	_	24	conj	_	_
28	in	in	IN	IN	_	29	case	_	_
29	PBMC	pbmc	NNS	NNS	_	24	nmod	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	55	55	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	24	conj	_	_
33	+/-	+/-	CC	CC	_	32	cc	_	_
34	4.4	4.4	CD	CD	_	35	nummod	_	_
35	%	%	NN	NN	_	32	conj	_	_
36	in	in	IN	IN	_	38	case	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	by	by	IN	IN	_	41	case	_	_
40	all-trans	all-trans	JJ	JJ	_	41	amod	_	_
41	RA	ra	NN	NN	_	24	nmod	_	_
42	,	,	,	,	_	24	punct	_	_
43	and	and	CC	CC	_	24	cc	_	_
44	58	58	CD	CD	_	45	nummod	_	_
45	%	%	NN	NN	_	24	conj	_	_
46	+/-	+/-	CC	CC	_	45	cc	_	_
47	6.7	6.7	CD	CD	_	48	nummod	_	_
48	%	%	NN	NN	_	45	conj	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	51	51	CD	CD	_	51	nummod	_	_
51	%	%	NN	NN	_	45	conj	_	_
52	+/-	+/-	CC	CC	_	51	cc	_	_
53	4.7	4.7	CD	CD	_	54	nummod	_	_
54	%	%	NN	NN	_	51	conj	_	_
55	,	,	,	,	_	45	punct	_	_
56	respectively	respectively	RB	RB	_	45	nmod	_	_
57	by	by	IN	IN	_	59	case	_	_
58	13-cis	13-cis	JJ	JJ	_	59	amod	_	_
59	RA	ra	NN	NN	_	56	nmod	_	_
60	.	.	.	.	_	11	punct	_	_

1	IgE	ige	NN	NN	_	2	compound	_	_
2	synthesis	synthesis	NN	NN	_	7	nsubjpass	_	_
3	was	be	VBD	VBD	_	7	auxpass	_	_
4	even	even	RB	RB	_	6	advmod	_	_
5	more	more	RBR	RBR	_	6	advmod	_	_
6	markedly	markedly	RB	RB	_	7	advmod	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	RA	ra	NN	NN	_	7	nmod	_	_
10	starting	start	VBG	VBG	_	7	xcomp	_	_
11	at	at	IN	IN	_	12	case	_	_
12	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	16	mark	_	_
14	&gt;	&gt;	JJR	JJR	_	16	dep	_	_
15	10(-14)	10(-14)	CD	CD	_	16	nummod	_	_
16	mol/L	mol/l	NN	NN	_	12	acl	_	_
17	for	for	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	&gt;	&gt;	JJR	JJR	_	23	dep	_	_
22	10(-10)	10(-10)	CD	CD	_	23	nummod	_	_
23	mol/L	mol/l	NN	NN	_	16	conj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	PBMC	pbmc	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Maximal	maximal	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IgE	ige	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	12	cop	_	_
10	at	at	IN	IN	_	12	case	_	_
11	10(-8)	10(-8)	CD	CD	_	12	nummod	_	_
12	mol/L	mol/l	NN	NN	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	all-trans	all-trans	JJ	JJ	_	15	amod	_	_
15	RA	ra	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	94	94	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	12	dep	_	_
19	+/-	+/-	CC	CC	_	18	cc	_	_
20	1.8	1.8	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	18	conj	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	96	96	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	12	conj	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	3.2	3.2	CD	CD	_	28	nummod	_	_
28	%	%	NN	NN	_	25	conj	_	_
29	for	for	IN	IN	_	31	case	_	_
30	13-cis	13-cis	JJ	JJ	_	31	amod	_	_
31	RA	ra	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Low	low	JJ	JJ	_	2	amod	_	_
2	concentrations	concentration	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	RA	ra	NN	NN	_	2	nmod	_	_
5	inhibiting	inhibit	VBG	VBG	_	4	acl	_	_
6	IgE	ige	NN	NN	_	7	compound	_	_
7	synthesis	synthesis	NN	NN	_	5	dobj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	10(-10)	10(-10)	CD	CD	_	10	nummod	_	_
10	mol/L	mol/l	NN	NN	_	2	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	affected	affect	VBD	VBD	_	0	root	_	_
13	neither	neither	CC	CC	_	15	cc:preconj	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	12	dobj	_	_
16	nor	nor	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	production	production	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	IgA	iga	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	IgG	igg	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	IgM	igm	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	Elucidation	elucidation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	1	nmod	_	_
5	involved	involve	VBN	VBN	_	1	acl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	inhibition	inhibition	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IgE	ige	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	8	nmod	_	_
12	shows	show	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	epsilon	epsilon	NN	NN	_	16	compound	_	_
15	germline	germline	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	decreased	decrease	VBN	VBN	_	12	ccomp	_	_
19	by	by	IN	IN	_	20	case	_	_
20	RA	ra	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	18	punct	_	_
22	whereas	whereas	IN	IN	_	31	mark	_	_
23	production	production	NN	NN	_	31	nsubjpass	_	_
24	of	of	IN	IN	_	25	case	_	_
25	interferon-gamma	interferon-gamma	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IFN-gamma	ifn-gamma	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	was	be	VBD	VBD	_	31	auxpass	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	enhanced	enhance	VBN	VBN	_	18	advcl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	presence	presence	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	RA	ra	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	differentiate	differentiate	VB	VB	_	30	advcl	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	RA	ra	NN	NN	_	6	compound	_	_
6	effect	effect	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
9	by	by	IN	IN	_	11	case	_	_
10	RA	ra	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	alpha	alpha	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	beta	beta	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	gamma	gamma	NN	NN	_	12	conj	_	_
18	,	,	,	,	_	30	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	30	nsubjpass	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	retinoic	retinoic	JJ	JJ	_	25	amod	_	_
24	acid	acid	NN	NN	_	25	compound	_	_
25	receptors	receptor	NNS	NNS	_	20	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	RAR	rar	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	examined	examine	VBN	VBN	_	0	root	_	_
31	by	by	IN	IN	_	35	case	_	_
32	reverse	reverse	JJ	JJ	_	35	amod	_	_
33	transcriptase-polymerase	transcriptase-polymerase	JJ	JJ	_	35	amod	_	_
34	chain	chain	NN	NN	_	35	compound	_	_
35	reaction	reaction	NN	NN	_	30	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	RT-PCR	rt-pcr	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	30	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	unstimulated	unstimulated	JJ	JJ	_	9	amod	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	10	nsubj	_	_
10	express	express	VBP	VBP	_	3	ccomp	_	_
11	mRNA	mrna	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	RA	ra	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	alpha	alpha	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	beta	beta	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	gamma	gamma	NN	NN	_	16	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	24	advcl	_	_
2	retinoids	retinoid	NNS	NNS	_	1	dobj	_	_
3	with	with	IN	IN	_	7	case	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	receptor	receptor	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	specificity	specificity	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	CD336	cd336	NN	NN	_	7	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	CD437	cd437	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	CD2019	cd2019	NN	NN	_	9	appos	_	_
14	,	,	,	,	_	9	punct	_	_
15	CD367	cd367	NN	NN	_	9	appos	_	_
16	)	)	-RRB-	-RRB-	_	9	punct	_	_
17	,	,	,	,	_	24	punct	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	inhibition	inhibition	NN	NN	_	24	nsubjpass	_	_
20	of	of	IN	IN	_	22	case	_	_
21	IgE	ige	NN	NN	_	22	compound	_	_
22	synthesis	synthesis	NN	NN	_	19	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	shown	show	VBN	VBN	_	0	root	_	_
25	by	by	IN	IN	_	28	case	_	_
26	all	all	DT	DT	_	28	det	_	_
27	four	four	CD	CD	_	28	nummod	_	_
28	derivates	derivate	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	but	but	CC	CC	_	24	cc	_	_
31	was	be	VBD	VBD	_	33	auxpass	_	_
32	most	most	RBS	RBS	_	33	advmod	_	_
33	marked	mark	VBN	VBN	_	24	conj	_	_
34	by	by	IN	IN	_	36	case	_	_
35	an	a	DT	DT	_	36	det	_	_
36	RA	ra	NN	NN	_	33	nmod	_	_
37	binding	bind	VBG	VBG	_	36	acl	_	_
38	the	the	DT	DT	_	40	det	_	_
39	alpha	alpha	NN	NN	_	40	compound	_	_
40	receptor	receptor	NN	NN	_	37	dobj	_	_
41	with	with	IN	IN	_	43	case	_	_
42	high	high	JJ	JJ	_	43	amod	_	_
43	specificity	specificity	NN	NN	_	37	nmod	_	_
44	.	.	.	.	_	24	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	6	nsubj	_	_
6	shows	show	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	RA	ra	NN	NN	_	9	nsubj	_	_
9	inhibits	inhibit	VBZ	VBZ	_	6	ccomp	_	_
10	IgE	ige	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	anti-CD40	anti-cd40	NN	NN	_	17	compound	_	_
14	+	+	CC	CC	_	13	cc	_	_
15	IL-4-stimulated	il-4-stimulated	JJ	JJ	_	13	conj	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	9	advmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Copyright	copyright	NN	NN	_	0	root	_	_
2	1998	1998	CD	CD	_	1	nummod	_	_
3	by	by	IN	IN	_	6	case	_	_
4	The	The	NNP	NNP	_	6	compound	_	_
5	American	American	NNP	NNP	_	6	compound	_	_
6	Society	Society	NNP	NNP	_	1	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Hematology	Hematology	NNP	NNP	_	6	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	CIITA	ciita	NN	NN	_	4	compound	_	_
2	B-cell-specific	b-cell-specific	JJ	JJ	_	4	amod	_	_
3	promoter	promoter	NN	NN	_	4	compound	_	_
4	suppression	suppression	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	MHC	mhc	NN	NN	_	10	compound	_	_
7	class	class	NN	NN	_	10	compound	_	_
8	II-silenced	ii-silenced	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	hybrids	hybrid	NNS	NNS	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	26	nmod	_	_
4	,	,	,	,	_	26	punct	_	_
5	various	various	JJ	JJ	_	6	amod	_	_
6	sets	set	NNS	NNS	_	26	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	somatic	somatic	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	hybrids	hybrid	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	generated	generate	VBN	VBN	_	6	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	fusion	fusion	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	epithelial	epithelial	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	15	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	B-lymphoblastoid	b-lymphoblastoid	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	15	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	were	be	VBD	VBD	_	26	auxpass	_	_
26	analyzed	analyze	VBN	VBN	_	0	root	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	expression	expression	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	39	case	_	_
31	major	major	JJ	JJ	_	33	amod	_	_
32	histocompatibility	histocompatibility	NN	NN	_	33	compound	_	_
33	complex	complex	NN	NN	_	39	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	MHC	mhc	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	class	class	NN	NN	_	39	compound	_	_
38	II	ii	CD	CD	_	39	nummod	_	_
39	antigens	antigen	NNS	NNS	_	29	nmod	_	_
40	.	.	.	.	_	26	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	first	first	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	10	case	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mouse	mouse	NN	NN	_	6	conj	_	_
9	intraspecies	intraspecy	NNS	NNS	_	10	compound	_	_
10	hybrids	hybrid	NNS	NNS	_	3	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	coordinate	coordinate	JJ	JJ	_	14	amod	_	_
14	suppression	suppression	NN	NN	_	3	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	MHC	mhc	NN	NN	_	17	compound	_	_
17	class	class	NN	NN	_	14	nmod	_	_
18	II	ii	CD	CD	_	17	nummod	_	_
19	,	,	,	,	_	17	punct	_	_
20	Ii	ii	NN	NN	_	17	conj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	invariant	invariant	JJ	JJ	_	23	amod	_	_
23	chain	chain	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	HLA-DM	hla-dm	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	transcription	transcription	NN	NN	_	17	conj	_	_
29	,	,	,	,	_	14	punct	_	_
30	and	and	CC	CC	_	14	cc	_	_
31	the	the	DT	DT	_	32	det	_	_
32	release	release	NN	NN	_	14	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	silencing	silencing	NN	NN	_	32	nmod	_	_
36	by	by	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	addition	addition	NN	NN	_	32	nmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	interferon	interferon	NN	NN	_	41	compound	_	_
41	gamma	gamma	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	10	advcl	_	_
2	interspecies	interspecy	NNS	NNS	_	3	compound	_	_
3	hybrids	hybrid	NNS	NNS	_	1	dobj	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	segregation	segregation	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	chromosomes	chromosome	NNS	NNS	_	6	nmod	_	_
10	allowed	allow	VBD	VBD	_	0	root	_	_
11	us	we	PRP	PRP	_	10	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	establish	establish	VB	VB	_	10	xcomp	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	MHC	mhc	NN	NN	_	18	compound	_	_
16	class	class	NN	NN	_	18	compound	_	_
17	II	ii	CD	CD	_	18	nummod	_	_
18	extinction	extinction	NN	NN	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	linked	link	VBN	VBN	_	13	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	presence	presence	NN	NN	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	hybrids	hybrid	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	chromosomes	chromosome	NNS	NNS	_	26	nmod	_	_
30	from	from	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	epithelial	epithelial	JJ	JJ	_	34	amod	_	_
33	fusion	fusion	NN	NN	_	34	compound	_	_
34	partner	partner	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	expression	expression	NN	NN	_	10	compound	_	_
10	pattern	pattern	NN	NN	_	17	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	MHC	mhc	NN	NN	_	15	compound	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	mRNA	mrna	NN	NN	_	10	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	correlated	correlate	VBN	VBN	_	6	dep	_	_
18	with	with	IN	IN	_	19	case	_	_
19	that	that	DT	DT	_	17	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	class	class	NN	NN	_	24	compound	_	_
23	II	ii	CD	CD	_	24	nummod	_	_
24	transactivator	transactivator	NN	NN	_	19	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CIITA	ciita	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	17	punct	_	_
29	suggesting	suggest	VBG	VBG	_	17	xcomp	_	_
30	that	that	IN	IN	_	35	mark	_	_
31	CIITA	ciita	NN	NN	_	35	nsubj	_	_
32	is	be	VBZ	VBZ	_	35	cop	_	_
33	the	the	DT	DT	_	35	det	_	_
34	actual	actual	JJ	JJ	_	35	amod	_	_
35	target	target	NN	NN	_	29	ccomp	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	silencing	silencing	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	10	dep	_	_
3	further	further	JJ	JJ	_	4	amod	_	_
4	insight	insight	NN	NN	_	2	dobj	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	suppression	suppression	NN	NN	_	8	compound	_	_
8	phenomenon	phenomenon	NN	NN	_	4	nmod	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	performed	perform	VBD	VBD	_	0	root	_	_
11	luciferase	luciferase	NN	NN	_	12	compound	_	_
12	assays	assay	NNS	NNS	_	10	dobj	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	show	show	VBP	VBP	_	12	acl:relcl	_	_
15	that	that	IN	IN	_	17	mark	_	_
16	silencing	silencing	NN	NN	_	17	nsubj	_	_
17	affects	affect	VBZ	VBZ	_	14	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activity	activity	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	B-cell-specific	b-cell-specific	JJ	JJ	_	23	amod	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	CIITA	ciita	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	11	det	_	_
7	MHC	mhc	NN	NN	_	11	compound	_	_
8	class	class	NN	NN	_	11	compound	_	_
9	II	ii	CD	CD	_	11	nummod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	silencing	silencing	NN	NN	_	17	nsubj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	somatic	somatic	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	hybrids	hybrid	NNS	NNS	_	11	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	due	due	JJ	JJ	_	4	ccomp	_	_
18	to	to	TO	TO	_	21	case	_	_
19	an	a	DT	DT	_	21	det	_	_
20	active	active	JJ	JJ	_	21	amod	_	_
21	suppression	suppression	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	one	one	CD	CD	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	promoters	promoter	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	CIITA	ciita	NN	NN	_	30	compound	_	_
30	gene	gene	NN	NN	_	26	nmod	_	_
31	,	,	,	,	_	21	punct	_	_
32	mediated	mediate	VBN	VBN	_	21	acl	_	_
33	by	by	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	epithelial	epithelial	JJ	JJ	_	38	amod	_	_
36	cell	cell	NN	NN	_	38	compound	_	_
37	fusion	fusion	NN	NN	_	38	compound	_	_
38	partner	partner	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	8	nsubj	_	_
4	c-myb	c-myb	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	C/EBP	c/ebp	NN	NN	_	7	compound	_	_
7	alpha	alpha	NN	NN	_	4	conj	_	_
8	regulate	regulate	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	monocytic/myeloic	monocytic/myeloic	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	8	dobj	_	_
12	MRP14	mrp14	NN	NN	_	11	dep	_	_
13	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	entry	entry	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	microorganisms	microorganism	NNS	NNS	_	2	nmod	_	_
5	into	into	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	body	body	NN	NN	_	2	nmod	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
10	processes	process	NNS	NNS	_	8	dobj	_	_
11	.	.	.	.	_	8	punct	_	_

1	During	during	IN	IN	_	3	mark	_	_
2	this	this	DT	DT	_	3	nsubj	_	_
3	process	process	NN	NN	_	16	advcl	_	_
4	a	a	DT	DT	_	5	det	_	_
5	sequence	sequence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cellular	cellular	JJ	JJ	_	5	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	humoral	humoral	JJ	JJ	_	16	nsubjpass	_	_
10	,	,	,	,	_	9	punct	_	_
11	non-specific	non-specific	JJ	JJ	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	specific	specific	JJ	JJ	_	9	conj	_	_
14	actions	action	NNS	NNS	_	9	dep	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	evoked	evoke	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	combat	combat	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	20	det	_	_
20	infection	infection	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	16	punct	_	_

1	Macrophages	macrophage	NNS	NNS	_	17	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	granulocytes	granulocyte	NNS	NNS	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	which	which	WDT	WDT	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	developed	develop	VBN	VBN	_	1	acl:relcl	_	_
8	from	from	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	common	common	JJ	JJ	_	12	amod	_	_
11	progenitor	progenitor	NN	NN	_	12	compound	_	_
12	cell	cell	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	17	punct	_	_
14	are	be	VBP	VBP	_	17	cop	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	components	component	NNS	NNS	_	0	root	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	specific	specific	JJ	JJ	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	non-specific	non-specific	JJ	JJ	_	20	conj	_	_
23	immunoreaction	immunoreaction	NN	NN	_	20	dep	_	_
24	.	.	.	.	_	17	punct	_	_

1	MRP14	mrp14	NN	NN	_	7	compound	_	_
2	(	(	-LRB-	-LRB-	_	7	punct	_	_
3	Macrophage	macrophage	NN	NN	_	7	compound	_	_
4	migration	migration	NN	NN	_	7	compound	_	_
5	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
6	related	related	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	24	nsubj	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	MRP8	mrp8	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	7	punct	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	S-100	s-100	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	7	appos	_	_
15	contained	contain	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	concentrations	concentration	NNS	NNS	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	obviously	obviously	RB	RB	_	24	advmod	_	_
24	essential	essential	JJ	JJ	_	0	root	_	_
25	for	for	IN	IN	_	26	case	_	_
26	adhesion	adhesion	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	migration	migration	NN	NN	_	26	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	monocytes	monocyte	NNS	NNS	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	granulocytes	granulocyte	NNS	NNS	_	30	conj	_	_
33	.	.	.	.	_	24	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	10	dep	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	regulation	regulation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	cotransfected	cotransfect	VBD	VBD	_	0	root	_	_
11	constructs	construct	NNS	NNS	_	10	dobj	_	_
12	expressing	express	VBG	VBG	_	11	acl	_	_
13	CAT	cat	NN	NN	_	12	dobj	_	_
14	under	under	IN	IN	_	15	case	_	_
15	control	control	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	MRP14	mrp14	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	11	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	C/EBP	c/ebp	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	v-myb	v-myb	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	two	two	CD	CD	_	31	nummod	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factors	factor	NNS	NNS	_	25	appos	_	_
32	involved	involve	VBN	VBN	_	31	acl	_	_
33	in	in	IN	IN	_	35	case	_	_
34	myeloid/monocytic	myeloid/monocytic	JJ	JJ	_	35	amod	_	_
35	differentiation	differentiation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	Transfection	transfection	NN	NN	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	C/EBP	c/ebp	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	1	nmod	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	massive	massive	JJ	JJ	_	8	amod	_	_
8	enhancement	enhancement	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	MRP14	mrp14	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	18	case	_	_
14	both	both	CC	CC	_	18	cc:preconj	_	_
15	,	,	,	,	_	18	punct	_	_
16	HL	hl	NN	NN	_	18	compound	_	_
17	60	60	CD	CD	_	18	nummod	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	granulocytic	granulocytic	JJ	JJ	_	21	dep	_	_
21	differentiated	differentiate	VBN	VBN	_	18	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	L132	l132	NN	NN	_	25	compound	_	_
25	fibroblasts	fibroblast	NNS	NNS	_	18	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	v-myb	v-myb	NN	NN	_	5	nsubj	_	_
5	reduces	reduce	VBZ	VBZ	_	0	root	_	_
6	MRP14	mrp14	NN	NN	_	8	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	L132	l132	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	transfected	transfect	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	C/EBP	c/ebp	NN	NN	_	13	compound	_	_
11	alpha	alpha	NN	NN	_	13	compound	_	_
12	expression	expression	NN	NN	_	13	compound	_	_
13	vector	vector	NN	NN	_	7	nmod	_	_
14	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	C/EBP	c/ebp	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	sufficient	sufficient	JJ	JJ	_	14	ccomp	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	enhance	enhance	VB	VB	_	19	xcomp	_	_
22	MRP14	mrp14	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	context	context	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	whole	whole	JJ	JJ	_	30	amod	_	_
30	genome	genome	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappaB	factor-kappab	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	CD45RO+	cd45ro+	JJ	JJ	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	CD45RA+	cd45ra+	JJ	JJ	_	5	conj	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	subsets	subset	NNS	NNS	_	5	dep	_	_
11	during	during	IN	IN	_	12	case	_	_
12	aging	aging	NN	NN	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	14	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	ratio	ratio	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	memory	memory	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	11	case	_	_
9	naive	naive	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	postulated	postulate	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	underlie	underlie	VB	VB	_	14	xcomp	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	hyporesponsiveness	hyporesponsiveness	NN	NN	_	16	dobj	_	_
19	accompanying	accompany	VBG	VBG	_	18	acl	_	_
20	aging	aging	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	14	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	analyses	analysis	NNS	NNS	_	32	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	induction	induction	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	factor-kappaB	factor-kappab	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	NFkappaB	nfkappab	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	activated	activate	VBN	VBN	_	14	amod	_	_
14	memory	memory	NN	NN	_	8	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	CD45RO+	cd45ro+	JJ	JJ	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	naive	naive	JJ	JJ	_	14	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CD45RA+	cd45ra+	JJ	JJ	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	T	t	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	subsets	subset	NNS	NNS	_	14	dep	_	_
26	from	from	IN	IN	_	27	case	_	_
27	young	young	JJ	JJ	_	14	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	elderly	elderly	JJ	JJ	_	27	conj	_	_
30	donors	donor	NNS	NNS	_	27	dep	_	_
31	has	have	VBZ	VBZ	_	32	aux	_	_
32	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
33	that	that	IN	IN	_	46	mark	_	_
34	,	,	,	,	_	46	punct	_	_
35	regardless	regardless	RB	RB	_	46	advmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	donor	donor	NN	NN	_	38	compound	_	_
38	age	age	NN	NN	_	35	nmod	_	_
39	,	,	,	,	_	46	punct	_	_
40	memory	memory	NN	NN	_	42	compound	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	46	nsubjpass	_	_
43	are	be	VBP	VBP	_	46	auxpass	_	_
44	not	not	RB	RB	_	46	neg	_	_
45	significantly	significantly	RB	RB	_	46	advmod	_	_
46	altered	alter	VBN	VBN	_	32	ccomp	_	_
47	in	in	IN	IN	_	49	case	_	_
48	their	they	PRP$	PRP$	_	49	nmod:poss	_	_
49	responsiveness	responsiveness	NN	NN	_	46	nmod	_	_
50	to	to	TO	TO	_	52	case	_	_
51	TNF-alpha-mediated	tnf-alpha-mediated	JJ	JJ	_	52	amod	_	_
52	induction	induction	NN	NN	_	49	nmod	_	_
53	of	of	IN	IN	_	54	case	_	_
54	NFkappaB	nfkappab	NN	NN	_	52	nmod	_	_
55	.	.	.	.	_	32	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	treatment	treatment	NN	NN	_	5	nsubj	_	_
3	with	with	IN	IN	_	4	case	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	2	nmod	_	_
5	induced	induce	VBD	VBD	_	34	advcl	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	localization	localization	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NFkappaB	nfkappab	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	memory	memory	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	naive	naive	JJ	JJ	_	12	conj	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	subsets	subset	NNS	NNS	_	12	dep	_	_
18	,	,	,	,	_	5	punct	_	_
19	irrespective	irrespective	RB	RB	_	5	advmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	age	age	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	donor	donor	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	34	punct	_	_
27	the	the	DT	DT	_	28	det	_	_
28	levels	level	NNS	NNS	_	34	nsubj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	induced	induce	VBN	VBN	_	31	amod	_	_
31	NFkappaB	nfkappab	NN	NN	_	28	nmod	_	_
32	were	be	VBD	VBD	_	34	cop	_	_
33	significantly	significantly	RB	RB	_	34	advmod	_	_
34	lower	lower	JJR	JJR	_	0	root	_	_
35	in	in	IN	IN	_	37	case	_	_
36	both	both	DT	DT	_	37	dep	_	_
37	subsets	subset	NNS	NNS	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	37	nmod	_	_
41	obtained	obtain	VBN	VBN	_	37	acl	_	_
42	from	from	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	elderly	elderly	JJ	JJ	_	41	nmod	_	_
45	,	,	,	,	_	34	punct	_	_
46	when	when	WRB	WRB	_	47	advmod	_	_
47	compared	compare	VBN	VBN	_	34	ccomp	_	_
48	to	to	TO	TO	_	49	case	_	_
49	those	those	DT	DT	_	47	nmod	_	_
50	in	in	IN	IN	_	51	case	_	_
51	young	young	JJ	JJ	_	49	nmod	_	_
52	.	.	.	.	_	34	punct	_	_

1	Examination	examination	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IkappaB	ikappab	NN	NN	_	5	compound	_	_
4	alpha	alpha	NN	NN	_	5	compound	_	_
5	regulation	regulation	NN	NN	_	1	nmod	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	25	mark	_	_
8	TNF-alpha-mediated	tnf-alpha-mediated	JJ	JJ	_	9	amod	_	_
9	degradation	degradation	NN	NN	_	25	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IkappaB	ikappab	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	memory	memory	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	naive	naive	JJ	JJ	_	15	conj	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	dep	_	_
20	from	from	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	elderly	elderly	JJ	JJ	_	15	nmod	_	_
23	was	be	VBD	VBD	_	25	aux	_	_
24	severely	severely	RB	RB	_	25	advmod	_	_
25	impaired	impaired	JJ	JJ	_	6	ccomp	_	_
26	,	,	,	,	_	25	punct	_	_
27	thus	thus	RB	RB	_	28	advmod	_	_
28	contributing	contribute	VBG	VBG	_	25	ccomp	_	_
29	to	to	TO	TO	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	lowered	lowered	JJ	JJ	_	32	amod	_	_
32	induction	induction	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	observed	observe	VBN	VBN	_	36	amod	_	_
36	NFkappaB	nfkappab	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	this	this	DT	DT	_	6	det	_	_
5	age-related	age-related	JJ	JJ	_	6	amod	_	_
6	decrease	decrease	NN	NN	_	12	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	induction	induction	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	NFkappaB	nfkappab	NN	NN	_	8	nmod	_	_
12	correlated	correlate	VBD	VBD	_	0	root	_	_
13	with	with	IN	IN	_	14	case	_	_
14	decrease	decrease	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	intracellular	intracellular	JJ	JJ	_	19	amod	_	_
17	IL-2	il-2	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	22	amod	_	_
22	proliferation	proliferation	NN	NN	_	19	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	memory	memory	NN	NN	_	19	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	naive	naive	JJ	JJ	_	25	conj	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cells	cell	NNS	NNS	_	30	compound	_	_
30	subsets	subset	NNS	NNS	_	25	dep	_	_
31	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	age-related	age-related	JJ	JJ	_	10	amod	_	_
10	hyporesponsiveness	hyporesponsiveness	NN	NN	_	14	nsubjpass	_	_
11	can	can	MD	MD	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	attributed	attribute	VBN	VBN	_	6	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	skewing	skewing	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	population	population	NN	NN	_	17	nmod	_	_
23	towards	towards	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	memory	memory	NN	NN	_	26	compound	_	_
26	phenotype	phenotype	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	elderly	elderly	JJ	JJ	_	26	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	E2F-mediated	e2f-mediated	JJ	JJ	_	4	amod	_	_
4	transcription	transcription	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	13	case	_	_
6	human	human	JJ	JJ	_	13	amod	_	_
7	T-cell	t-cell	NN	NN	_	13	compound	_	_
8	leukemia	leukemia	NN	NN	_	13	compound	_	_
9	virus	virus	NN	NN	_	13	compound	_	_
10	type	type	NN	NN	_	13	compound	_	_
11	I	i	CD	CD	_	13	nummod	_	_
12	Tax	tax	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	1	nmod	_	_
14	in	in	IN	IN	_	22	case	_	_
15	a	a	DT	DT	_	22	det	_	_
16	p16	p16	NN	NN	_	22	compound	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	INK4A	ink4a	NN	NN	_	22	compound	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	-negative	-negative	JJ	JJ	_	22	amod	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	line	line	NN	NN	_	13	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	T-cell	t-cell	NN	NN	_	6	compound	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type	type	NN	NN	_	14	nsubj	_	_
7	I	i	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	causative	causative	JJ	JJ	_	14	amod	_	_
14	agent	agent	NN	NN	_	0	root	_	_
15	of	of	IN	IN	_	18	case	_	_
16	adult	adult	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	leukemia	leukemia	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	exact	exact	NN	NN	_	4	compound	_	_
4	mechanism	mechanism	NN	NN	_	13	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	HTLV-I	htlv-i	NN	NN	_	8	nsubj	_	_
8	contributes	contribute	VBZ	VBZ	_	4	acl:relcl	_	_
9	to	to	TO	TO	_	10	case	_	_
10	leukemogenesis	leukemogenesis	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	still	still	RB	RB	_	13	advmod	_	_
13	unclear	unclear	JJ	JJ	_	19	advcl	_	_
14	,	,	,	,	_	19	punct	_	_
15	the	the	DT	DT	_	17	det	_	_
16	Tax	tax	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	thought	think	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	play	play	VB	VB	_	19	xcomp	_	_
22	a	a	DT	DT	_	24	det	_	_
23	major	major	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	process	process	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	40-kDa	40-kda	JJ	JJ	_	3	amod	_	_
3	polypeptide	polypeptide	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	interact	interact	VB	VB	_	5	xcomp	_	_
8	with	with	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	tumor	tumor	NN	NN	_	14	compound	_	_
11	suppressor	suppressor	NN	NN	_	14	compound	_	_
12	p16	p16	NN	NN	_	14	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	INK4A	ink4a	NN	NN	_	7	nmod	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	5	punct	_	_

1	Consequently	consequently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Tax	tax	NN	NN	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	activate	activate	VB	VB	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	lead	lead	VBP	VBP	_	8	acl:relcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	release	release	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	E2F	e2f	NN	NN	_	13	nmod	_	_
16	that	that	WDT	WDT	_	19	nsubj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	turn	turn	NN	NN	_	19	nmod	_	_
19	induces	induce	VBZ	VBZ	_	15	acl:relcl	_	_
20	expression	expression	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	factors	factor	NNS	NNS	_	20	nmod	_	_
23	required	require	VBN	VBN	_	22	acl	_	_
24	for	for	IN	IN	_	27	case	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	cycle	cycle	NN	NN	_	27	compound	_	_
27	progression	progression	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	Tax	tax	NN	NN	_	11	nsubj	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	activate	activate	VB	VB	_	6	ccomp	_	_
12	E2F-mediated	e2f-mediated	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	independently	independently	RB	RB	_	11	advmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	p16	p16	NN	NN	_	18	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	INK4A	ink4a	NN	NN	_	14	nmod	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	6	punct	_	_

1	Indeed	indeed	RB	RB	_	27	advmod	_	_
2	,	,	,	,	_	27	punct	_	_
3	when	when	WRB	WRB	_	6	advmod	_	_
4	Tax	tax	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	coexpressed	coexpress	VBN	VBN	_	27	advcl	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	E2F-1	e2f-1	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	CEM	cem	NN	NN	_	14	compound	_	_
14	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	lack	lack	VBP	VBP	_	14	acl:relcl	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	p16	p16	NN	NN	_	22	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	INK4A	ink4a	NN	NN	_	18	nmod	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	27	punct	_	_
25	it	it	PRP	PRP	_	27	nsubj	_	_
26	strongly	strongly	RB	RB	_	27	advmod	_	_
27	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
28	the	the	DT	DT	_	30	det	_	_
29	E2F-dependent	e2f-dependent	JJ	JJ	_	30	amod	_	_
30	activation	activation	NN	NN	_	27	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	reporter	reporter	NN	NN	_	34	compound	_	_
34	construct	construct	NN	NN	_	30	nmod	_	_
35	driven	drive	VBN	VBN	_	34	acl	_	_
36	by	by	IN	IN	_	38	case	_	_
37	a	a	DT	DT	_	38	det	_	_
38	promoter	promoter	NN	NN	_	35	nmod	_	_
39	containing	contain	VBG	VBG	_	38	acl	_	_
40	E2F	e2f	NN	NN	_	42	compound	_	_
41	binding	binding	NN	NN	_	42	compound	_	_
42	sites	site	NNS	NNS	_	39	dobj	_	_
43	.	.	.	.	_	27	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	stimulation	stimulation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	abrogated	abrogate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	mutations	mutation	NNS	NNS	_	4	nmod	_	_
7	affecting	affect	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	E2F-binding	e2f-binding	JJ	JJ	_	10	amod	_	_
10	sites	site	NNS	NNS	_	7	dobj	_	_
11	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	Tax	tax	NN	NN	_	6	nsubj	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	E2F-1	e2f-1	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	itself	itself	PRP	PRP	_	8	nmod:npmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	24	advcl	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	1	dobj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	fail	fail	VBP	VBP	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	5	xcomp	_	_
8	either	either	CC	CC	_	9	cc:preconj	_	_
9	ATF-	atf-	NN	NN	_	12	amod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	9	conj	_	_
12	promoters	promoter	NNS	NNS	_	7	dobj	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	different	different	JJ	JJ	_	17	amod	_	_
15	5'	5'	JJ	JJ	_	17	amod	_	_
16	truncation	truncation	NN	NN	_	17	compound	_	_
17	mutants	mutant	NNS	NNS	_	3	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	E2F-1	e2f-1	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	show	show	VBP	VBP	_	0	root	_	_
25	that	that	IN	IN	_	34	mark	_	_
26	the	the	DT	DT	_	29	det	_	_
27	Tax-dependent	tax-dependent	JJ	JJ	_	29	amod	_	_
28	transcriptional	transcriptional	JJ	JJ	_	29	amod	_	_
29	control	control	NN	NN	_	34	nsubj	_	_
30	of	of	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	E2F1	e2f1	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	involves	involve	VBZ	VBZ	_	24	ccomp	_	_
35	,	,	,	,	_	34	punct	_	_
36	at	at	IN	IN	_	39	advmod	_	_
37	least	least	JJS	JJS	_	36	mwe	_	_
38	in	in	IN	IN	_	39	case	_	_
39	part	part	NN	NN	_	34	nmod	_	_
40	,	,	,	,	_	34	punct	_	_
41	the	the	DT	DT	_	44	det	_	_
42	ATF	atf	NN	NN	_	44	compound	_	_
43	binding	binding	NN	NN	_	44	compound	_	_
44	site	site	NN	NN	_	34	dobj	_	_
45	located	located	JJ	JJ	_	44	amod	_	_
46	in	in	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	E2F-1	e2f-1	NN	NN	_	49	compound	_	_
49	promoter	promoter	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	MHC	mhc	NN	NN	_	5	compound	_	_
3	class	class	NN	NN	_	5	compound	_	_
4	II	ii	CD	CD	_	5	nummod	_	_
5	transactivator	transactivator	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	CIITA	ciita	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	conserved	conserve	VBN	VBN	_	13	amod	_	_
11	leucine	leucine	NN	NN	_	13	compound	_	_
12	charged	charged	JJ	JJ	_	13	amod	_	_
13	domains	domain	NNS	NNS	_	9	dobj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	interactions	interaction	NNS	NNS	_	9	nmod	_	_
16	with	with	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	conserved	conserve	VBN	VBN	_	22	amod	_	_
19	W	w	NN	NN	_	22	compound	_	_
20	box	box	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	element	element	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	class	class	NN	NN	_	5	compound	_	_
3	II	ii	CD	CD	_	5	nummod	_	_
4	transactivator	transactivator	NN	NN	_	5	compound	_	_
5	CIITA	ciita	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	21	case	_	_
12	the	the	DT	DT	_	21	det	_	_
13	major	major	JJ	JJ	_	21	amod	_	_
14	histocompatibility	histocompatibility	NN	NN	_	21	compound	_	_
15	complex	complex	NN	NN	_	21	compound	_	_
16	(	(	-LRB-	-LRB-	_	21	punct	_	_
17	MHC	mhc	NN	NN	_	21	compound	_	_
18	)	)	-RRB-	-RRB-	_	21	punct	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	genes	gene	NNS	NNS	_	10	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Aside	aside	IN	IN	_	8	case	_	_
2	from	from	IN	IN	_	8	case	_	_
3	an	a	DT	DT	_	8	det	_	_
4	N-terminal	n-terminal	JJ	JJ	_	8	amod	_	_
5	acidic	acidic	JJ	JJ	_	8	amod	_	_
6	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
7	activation	activation	NN	NN	_	8	compound	_	_
8	domain	domain	NN	NN	_	12	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	little	little	JJ	JJ	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	known	know	VBN	VBN	_	0	root	_	_
13	about	about	IN	IN	_	17	mark	_	_
14	how	how	WRB	WRB	_	17	advmod	_	_
15	this	this	DT	DT	_	16	det	_	_
16	factor	factor	NN	NN	_	17	nsubj	_	_
17	functions	function	VBZ	VBZ	_	12	advcl	_	_
18	.	.	.	.	_	12	punct	_	_

1	Extensive	extensive	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CIITA	ciita	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	undertaken	undertake	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	xcomp	_	_
9	structural	structural	JJ	JJ	_	10	amod	_	_
10	motifs	motif	NNS	NNS	_	8	dobj	_	_
11	required	require	VBN	VBN	_	10	acl	_	_
12	for	for	IN	IN	_	13	case	_	_
13	function	function	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	24	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	mutants	mutant	NNS	NNS	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	activate	activate	VB	VB	_	2	acl	_	_
7	a	a	DT	DT	_	9	det	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	6	dobj	_	_
10	under	under	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	control	control	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	MHC	mhc	NN	NN	_	17	nmod:npmod	_	_
15	class	class	NN	NN	_	17	nmod:npmod	_	_
16	II	ii	CD	CD	_	17	compound	_	_
17	conserved	conserved	JJ	JJ	_	18	amod	_	_
18	W-X-Y	w-x-y	NN	NN	_	12	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	X-Y	x-y	NN	NN	_	22	compound	_	_
21	regulatory	regulatory	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	18	conj	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	determined	determine	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	mutants	mutant	NNS	NNS	_	3	nsubj	_	_
3	displayed	display	VBD	VBD	_	0	root	_	_
4	differential	differential	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	promoters	promoter	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	activating	activate	VBG	VBG	_	3	advcl	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	W-X-Y	w-x-y	NN	NN	_	12	nmod	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	15	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	X-Y	x-y	NN	NN	_	15	conj	_	_
20	elements	element	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	mutants	mutant	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	tested	test	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	their	they	PRP$	PRP$	_	7	nmod:poss	_	_
7	ability	ability	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	interfere	interfere	VB	VB	_	7	acl	_	_
10	with	with	IN	IN	_	13	case	_	_
11	wild-type	wild-type	JJ	JJ	_	13	amod	_	_
12	CIITA	ciita	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Five	five	CD	CD	_	4	nummod	_	_
2	CIITA	ciita	NN	NN	_	4	compound	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	constructions	construction	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	able	able	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	down-regulate	down-regulate	VB	VB	_	6	xcomp	_	_
9	wild-type	wild-type	JJ	JJ	_	11	amod	_	_
10	CIITA	ciita	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	6	punct	_	_

1	Three	three	CD	CD	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	mutants	mutant	NNS	NNS	_	1	nmod	_	_
5	contained	contain	VBD	VBD	_	0	root	_	_
6	targeted	target	VBN	VBN	_	7	amod	_	_
7	disruptions	disruption	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	potential	potential	JJ	JJ	_	11	amod	_	_
10	functional	functional	JJ	JJ	_	11	amod	_	_
11	motifs	motif	NNS	NNS	_	7	nmod	_	_
12	:	:	:	:	_	11	punct	_	_
13	the	the	DT	DT	_	16	det	_	_
14	acidic	acidic	JJ	JJ	_	16	amod	_	_
15	activation	activation	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	11	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	21	det	_	_
19	putative	putative	JJ	JJ	_	21	amod	_	_
20	GTP-binding	gtp-binding	JJ	JJ	_	21	amod	_	_
21	motif	motif	NN	NN	_	16	conj	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	two	two	CD	CD	_	26	nummod	_	_
24	leucine	leucine	NN	NN	_	26	compound	_	_
25	charged	charged	JJ	JJ	_	26	amod	_	_
26	domains	domain	NNS	NNS	_	16	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	LCD	lcd	NNS	NNS	_	29	compound	_	_
29	motifs	motif	NNS	NNS	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	two	two	CD	CD	_	4	nsubj	_	_
4	contained	contain	VBD	VBD	_	0	root	_	_
5	mutations	mutation	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	regions	region	NNS	NNS	_	4	nmod	_	_
8	that	that	WDT	WDT	_	11	nsubj	_	_
9	do	do	VBP	VBP	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	have	have	VB	VB	_	7	acl:relcl	_	_
12	homology	homology	NN	NN	_	11	dobj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	described	describe	VBN	VBN	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	characterization	characterization	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CIITA	ciita	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	2	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	able	able	JJ	JJ	_	5	acl:relcl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	discriminate	discriminate	VB	VB	_	8	xcomp	_	_
11	between	between	IN	IN	_	12	case	_	_
12	promoters	promoter	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	18	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	without	without	IN	IN	_	13	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	W	w	NN	NN	_	18	compound	_	_
18	box	box	NN	NN	_	12	nmod	_	_
19	strongly	strongly	RB	RB	_	20	advmod	_	_
20	suggests	suggest	VBZ	VBZ	_	0	root	_	_
21	that	that	IN	IN	_	23	mark	_	_
22	CIITA	ciita	NN	NN	_	23	nsubj	_	_
23	requires	require	VBZ	VBZ	_	20	ccomp	_	_
24	such	such	JJ	JJ	_	25	amod	_	_
25	interactions	interaction	NNS	NNS	_	23	dobj	_	_
26	for	for	IN	IN	_	27	case	_	_
27	function	function	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	LCD	lcd	NNS	NNS	_	5	compound	_	_
5	motifs	motif	NNS	NNS	_	2	nmod	_	_
6	required	require	VBN	VBN	_	5	acl	_	_
7	for	for	IN	IN	_	9	case	_	_
8	CIITA	ciita	NN	NN	_	9	compound	_	_
9	function	function	NN	NN	_	6	nmod	_	_
10	brings	bring	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	light	light	NN	NN	_	10	nmod	_	_
13	a	a	DT	DT	_	16	det	_	_
14	previously	previously	RB	RB	_	15	advmod	_	_
15	undefined	undefine	VBN	VBN	_	16	amod	_	_
16	role	role	NN	NN	_	10	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	motifs	motif	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	CIITA	ciita	NN	NN	_	22	compound	_	_
22	function	function	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	Calcineurin	calcineurin	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	5	det	_	_
4	biological	biological	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	1	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cyclosporine	cyclosporine	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	tacrolimus	tacrolimus	NN	NN	_	7	conj	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	immunosuppressive	immunosuppressive	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CyA	cya	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	FK	fk	NN	NN	_	8	conj	_	_
11	506	506	CD	CD	_	10	nummod	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	monitored	monitor	VBN	VBN	_	0	root	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vivo	vivo	FW	FW	_	14	advmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	humans	human	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	picture	picture	NN	NN	_	8	nsubj	_	_
3	emerging	emerge	VBG	VBG	_	2	acl	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	close	close	JJ	JJ	_	8	amod	_	_
8	relationship	relationship	NN	NN	_	0	root	_	_
9	between	between	IN	IN	_	11	case	_	_
10	drug	drug	NN	NN	_	11	compound	_	_
11	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CN	cn	NN	NN	_	14	compound	_	_
14	inhibition	inhibition	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	8	punct	_	_

1	But	but	CC	CC	_	7	cc	_	_
2	many	many	JJ	JJ	_	3	amod	_	_
3	puzzles	puzzle	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	drugs	drug	NNS	NNS	_	3	nmod	_	_
7	remain	remain	VBP	VBP	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	What	what	WP	WP	_	0	root	_	_
2	is	be	VBZ	VBZ	_	1	cop	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CyA	cya	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	transforming	transform	VBG	VBG	_	13	amod	_	_
12	growth	growth	NN	NN	_	13	compound	_	_
13	factor-beta	factor-beta	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TGF-beta	tgf-beta	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	4	punct	_	_
18	particularly	particularly	RB	RB	_	20	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	relationship	relationship	NN	NN	_	4	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	nephrotoxicity	nephrotoxicity	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	fibrogenesis	fibrogenesis	NN	NN	_	22	conj	_	_
25	?	?	.	.	_	1	punct	_	_

1	How	how	WRB	WRB	_	2	advmod	_	_
2	important	important	JJ	JJ	_	3	dep	_	_
3	are	be	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	10	det	_	_
5	anti-inflammatory	anti-inflammatory	JJ	JJ	_	10	amod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	non	non	JJ	JJ	_	8	dep	_	_
8	T	t	NN	NN	_	5	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	effects	effect	NNS	NNS	_	3	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CyA	cya	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	which	which	WDT	WDT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	19	nmod	_	_
17	do	do	VBP	VBP	_	19	aux	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	operate	operate	VB	VB	_	3	conj	_	_
20	in	in	IN	IN	_	16	case	_	_
21	?	?	.	.	_	3	punct	_	_

1	Are	be	VBP	VBP	_	0	root	_	_
2	there	there	EX	EX	_	1	expl	_	_
3	effects	effect	NNS	NNS	_	1	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CyA	cya	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	FK	fk	NN	NN	_	5	conj	_	_
8	506	506	CD	CD	_	7	nummod	_	_
9	all	all	DT	DT	_	10	nmod:npmod	_	_
10	attributable	attributable	JJ	JJ	_	3	amod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	CN	cn	NN	NN	_	13	compound	_	_
13	inhibition	inhibition	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	1	punct	_	_
15	and	and	CC	CC	_	1	cc	_	_
16	how	how	WRB	WRB	_	17	advmod	_	_
17	much	much	JJ	JJ	_	21	nsubjpass	_	_
18	of	of	IN	IN	_	19	case	_	_
19	them	they	PRP	PRP	_	17	nmod	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	mediated	mediate	VBN	VBN	_	1	conj	_	_
22	through	through	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	NFATC	nfatc	NN	NN	_	25	compound	_	_
25	family	family	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	?	?	.	.	_	1	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	would	would	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	useful	useful	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	know	know	VB	VB	_	6	xcomp	_	_
9	what	what	WP	WP	_	17	dobj	_	_
10	the	the	DT	DT	_	12	det	_	_
11	inhibitory	inhibitory	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	17	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CyA	cya	NN	NN	_	12	nmod	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	on	on	IN	IN	_	17	case	_	_
17	tolerance	tolerance	NN	NN	_	8	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	negative	negative	JJ	JJ	_	21	amod	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	events	event	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	vitellogenin	vitellogenin	NN	NN	_	7	compound	_	_
5	gene	gene	NN	NN	_	7	compound	_	_
6	B1	b1	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	1	nmod	_	_
8	after	after	IN	IN	_	9	case	_	_
9	transfer	transfer	NN	NN	_	1	nmod	_	_
10	into	into	IN	IN	_	11	case	_	_
11	hepatocytes	hepatocyte	NNS	NNS	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	primary	primary	JJ	JJ	_	14	amod	_	_
14	cultures	culture	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	estrogen-dependent	estrogen-dependent	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	tissue-specific	tissue-specific	JJ	JJ	_	2	conj	_	_
5	regulation	regulation	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	Xenopus	xenopus	NN	NN	_	9	compound	_	_
9	laevis	laevis	NN	NN	_	5	nmod	_	_
10	vitellogenin	vitellogenin	NN	NN	_	13	compound	_	_
11	gene	gene	NN	NN	_	13	compound	_	_
12	B1	b1	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	dep	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	studied	study	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	20	case	_	_
18	lipid-mediated	lipid-mediated	JJ	JJ	_	20	amod	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	transfer	transfer	NN	NN	_	16	nmod	_	_
21	into	into	IN	IN	_	23	case	_	_
22	Xenopus	xenopus	NN	NN	_	23	compound	_	_
23	hepatocytes	hepatocyte	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	primary	primary	JJ	JJ	_	26	amod	_	_
26	culture	culture	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Hepatocytes	hepatocyte	NNS	NNS	_	2	nsubj	_	_
2	achieve	achieve	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	6	det	_	_
4	efficient	efficient	JJ	JJ	_	6	amod	_	_
5	hormonal	hormonal	JJ	JJ	_	6	amod	_	_
6	control	control	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	promoter	promoter	NN	NN	_	6	nmod	_	_
10	through	through	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	functional	functional	JJ	JJ	_	13	amod	_	_
13	interaction	interaction	NN	NN	_	2	nmod	_	_
14	between	between	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	estrogen	estrogen	NN	NN	_	18	compound	_	_
17	responsive	responsive	JJ	JJ	_	18	amod	_	_
18	elements	element	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	a	a	DT	DT	_	23	det	_	_
21	promoter	promoter	NN	NN	_	23	compound	_	_
22	proximal	proximal	JJ	JJ	_	23	amod	_	_
23	region	region	NN	NN	_	18	conj	_	_
24	upstream	upstream	JJ	JJ	_	23	amod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	TATA	tata	NN	NN	_	28	compound	_	_
28	box	box	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	23	punct	_	_
30	which	which	WDT	WDT	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	characterized	characterize	VBN	VBN	_	23	acl:relcl	_	_
33	by	by	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	high	high	JJ	JJ	_	36	amod	_	_
36	density	density	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	binding	bind	VBG	VBG	_	39	amod	_	_
39	sites	site	NNS	NNS	_	36	nmod	_	_
40	for	for	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	transcription	transcription	NN	NN	_	43	compound	_	_
43	factors	factor	NNS	NNS	_	39	nmod	_	_
44	CTF/NF-1	ctf/nf-1	NN	NN	_	43	dep	_	_
45	,	,	,	,	_	44	punct	_	_
46	C/EBP	c/ebp	NN	NN	_	44	conj	_	_
47	and	and	CC	CC	_	44	cc	_	_
48	HNF3	hnf3	NN	NN	_	44	conj	_	_
49	.	.	.	.	_	2	punct	_	_

1	DNA	dna	NN	NN	_	2	compound	_	_
2	accessibility	accessibility	NN	NN	_	16	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	restriction	restriction	NN	NN	_	5	compound	_	_
5	enzymes	enzyme	NNS	NNS	_	2	nmod	_	_
6	within	within	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	chromosomal	chromosomal	JJ	JJ	_	9	amod	_	_
9	copy	copy	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	vitellogenin	vitellogenin	NN	NN	_	15	compound	_	_
13	gene	gene	NN	NN	_	15	compound	_	_
14	B1	b1	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	9	nmod	_	_
16	shows	show	VBZ	VBZ	_	0	root	_	_
17	that	that	IN	IN	_	28	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	estrogen	estrogen	NN	NN	_	21	compound	_	_
20	responsive	responsive	JJ	JJ	_	21	amod	_	_
21	unit	unit	NN	NN	_	28	nsubj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	promoter	promoter	NN	NN	_	26	compound	_	_
25	proximal	proximal	JJ	JJ	_	26	amod	_	_
26	region	region	NN	NN	_	21	conj	_	_
27	are	be	VBP	VBP	_	28	cop	_	_
28	sensitive	sensitive	JJ	JJ	_	16	ccomp	_	_
29	to	to	TO	TO	_	30	case	_	_
30	digestion	digestion	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	35	case	_	_
32	uninduced	uninduced	JJ	JJ	_	35	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	estrogen-induced	estrogen-induced	JJ	JJ	_	32	conj	_	_
35	hepatocytes	hepatocyte	NNS	NNS	_	30	nmod	_	_
36	but	but	CC	CC	_	35	cc	_	_
37	not	not	RB	RB	_	40	neg	_	_
38	in	in	IN	IN	_	40	case	_	_
39	erythrocyte	erythrocyte	NN	NN	_	40	compound	_	_
40	nuclei	nucleus	NNS	NNS	_	35	conj	_	_
41	.	.	.	.	_	16	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	support	support	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	notion	notion	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	19	mark	_	_
9	chromatin	chromatin	NN	NN	_	10	compound	_	_
10	configuration	configuration	NN	NN	_	19	nsubj	_	_
11	as	as	RB	RB	_	10	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	the	the	DT	DT	_	15	det	_	_
15	interplay	interplay	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	elements	element	NNS	NNS	_	15	nmod	_	_
19	mediate	mediate	VBP	VBP	_	7	dep	_	_
20	proper	proper	JJ	JJ	_	24	amod	_	_
21	hormone-dependent	hormone-dependent	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	tissue-specific	tissue-specific	JJ	JJ	_	21	conj	_	_
24	expression	expression	NN	NN	_	19	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	B1	b1	NN	NN	_	29	compound	_	_
28	vitellogenin	vitellogenin	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	regulation	regulation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	human	human	JJ	JJ	_	12	amod	_	_
10	leukemic	leukemic	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	glucocorticoid-sensitive	glucocorticoid-sensitive	JJ	JJ	_	7	amod	_	_
7	6TG1.1	6tg1.1	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	resistant	resistant	JJ	JJ	_	10	amod	_	_
10	ICR27TK.3	icr27tk.3	NN	NN	_	7	conj	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	leukemic	leukemic	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	dep	_	_
15	.	.	.	.	_	4	punct	_	_

1	Following	follow	VBG	VBG	_	3	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	6TG1.1	6tg1.1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	chromatin	chromatin	NN	NN	_	9	compound	_	_
9	fragmentation	fragmentation	NN	NN	_	6	appos	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	after	after	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	delay	delay	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	24	24	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Fragmentation	fragmentation	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	ICR27TK.3	icr27tk.3	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	mutant	mutant	JJ	JJ	_	11	amod	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	L753F	l753f	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	activation-deficient	activation-deficient	JJ	JJ	_	11	acl:relcl	_	_
18	but	but	CC	CC	_	17	cc	_	_
19	retain	retain	VBP	VBP	_	17	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	ability	ability	NN	NN	_	19	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	repress	repress	VB	VB	_	21	acl	_	_
24	AP-1	ap-1	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	4	punct	_	_

1	Nor	nor	CC	CC	_	4	cc	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	fragmentation	fragmentation	NN	NN	_	4	nsubjpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	after	after	IN	IN	_	6	case	_	_
6	treatment	treatment	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	RU38486	ru38486	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	indicating	indicate	VBG	VBG	_	4	xcomp	_	_
11	that	that	IN	IN	_	18	mark	_	_
12	repression	repression	NN	NN	_	18	nsubjpass	_	_
13	of	of	IN	IN	_	15	case	_	_
14	AP-1	ap-1	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	involved	involve	VBN	VBN	_	10	ccomp	_	_
19	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	described	describe	VBN	VBN	_	8	advcl	_	_
3	in	in	IN	IN	_	5	case	_	_
4	other	other	JJ	JJ	_	5	amod	_	_
5	systems	system	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	fragmentation	fragmentation	NN	NN	_	8	nsubj	_	_
8	required	require	VBD	VBD	_	0	root	_	_
9	ongoing	ongoing	JJ	JJ	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	synthesis	synthesis	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	inhibition	inhibition	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	cycloheximide	cycloheximide	NN	NN	_	3	nmod	_	_
9	anytime	anytime	RB	RB	_	3	nmod	_	_
10	during	during	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	first	first	JJ	JJ	_	14	amod	_	_
13	18	18	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	steroid	steroid	NN	NN	_	17	compound	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	was	be	VBD	VBD	_	20	cop	_	_
19	as	as	IN	IN	_	20	dep	_	_
20	effective	effective	JJ	JJ	_	0	root	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	blocking	block	VBG	VBG	_	20	advcl	_	_
23	chromatin	chromatin	NN	NN	_	24	compound	_	_
24	fragmentation	fragmentation	NN	NN	_	22	dobj	_	_
25	as	as	IN	IN	_	26	case	_	_
26	inhibition	inhibition	NN	NN	_	20	nmod	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	entire	entire	JJ	JJ	_	30	amod	_	_
30	period	period	NN	NN	_	26	nmod	_	_
31	,	,	,	,	_	20	punct	_	_
32	suggesting	suggest	VBG	VBG	_	20	xcomp	_	_
33	that	that	IN	IN	_	44	mark	_	_
34	synthesis	synthesis	NN	NN	_	44	nsubjpass	_	_
35	of	of	IN	IN	_	37	case	_	_
36	a	a	DT	DT	_	37	det	_	_
37	component	component	NN	NN	_	34	nmod	_	_
38	with	with	IN	IN	_	42	case	_	_
39	a	a	DT	DT	_	42	det	_	_
40	rapid	rapid	JJ	JJ	_	42	amod	_	_
41	turnover	turnover	NN	NN	_	42	compound	_	_
42	rate	rate	NN	NN	_	34	nmod	_	_
43	is	be	VBZ	VBZ	_	44	auxpass	_	_
44	required	require	VBN	VBN	_	32	ccomp	_	_
45	.	.	.	.	_	20	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	4	nsubj	_	_
3	completely	completely	RB	RB	_	4	advmod	_	_
4	blocked	block	VBD	VBD	_	0	root	_	_
5	12-O-tetradecanoylphorbol	12-o-tetradecanoylphorbol	NN	NN	_	7	compound	_	_
6	13-acetate	13-acetate	NN	NN	_	7	compound	_	_
7	induction	induction	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	factor-kappaB	factor-kappab	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	activity	activity	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	elicited	elicit	VBD	VBD	_	4	conj	_	_
17	an	a	DT	DT	_	18	det	_	_
18	increase	increase	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	amount	amount	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	immunoreactive	immunoreactive	JJ	JJ	_	25	amod	_	_
24	IkappaB	ikappab	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	sensitive	sensitive	JJ	JJ	_	29	amod	_	_
28	6TG1.1	6tg1.1	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	but	but	CC	CC	_	29	cc	_	_
31	not	not	RB	RB	_	35	neg	_	_
32	in	in	IN	IN	_	35	case	_	_
33	resistant	resistant	JJ	JJ	_	35	amod	_	_
34	ICR27TK.3	icr27tk.3	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	29	conj	_	_
36	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	mild	mild	JJ	JJ	_	6	amod	_	_
5	detergent	detergent	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	extracts	extract	NNS	NNS	_	6	nmod	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	19	mark	_	_
12	a	a	DT	DT	_	14	det	_	_
13	substantial	substantial	JJ	JJ	_	14	amod	_	_
14	amount	amount	NN	NN	_	19	nsubjpass	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	14	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	complexed	complex	VBN	VBN	_	10	ccomp	_	_
20	with	with	IN	IN	_	22	case	_	_
21	IkappaB	ikappab	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	19	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	some	some	DT	DT	_	27	det	_	_
25	other	other	JJ	JJ	_	27	amod	_	_
26	inhibitory	inhibitory	JJ	JJ	_	27	amod	_	_
27	factor	factor	NN	NN	_	22	conj	_	_
28	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	induction	induction	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	labile	labile	JJ	JJ	_	10	amod	_	_
9	inhibitory	inhibitory	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	5	nmod	_	_
11	such	such	JJ	JJ	_	14	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	IkappaB	ikappab	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	10	nmod	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	contribute	contribute	VB	VB	_	3	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	19	amod	_	_
19	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	9	nsubj	_	_
4	from	from	IN	IN	_	5	case	_	_
5	women	woman	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	breast	breast	NN	NN	_	8	compound	_	_
8	cancer	cancer	NN	NN	_	5	nmod	_	_
9	exhibit	exhibit	VBP	VBP	_	0	root	_	_
10	abnormal	abnormal	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	several	several	JJ	JJ	_	16	amod	_	_
15	signaling	signal	VBG	VBG	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	signaling	signal	VBG	VBG	_	4	amod	_	_
4	molecules	molecule	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
7	blood	blood	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
10	obtained	obtain	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	12	case	_	_
12	women	woman	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	breast	breast	NN	NN	_	15	compound	_	_
15	cancer	cancer	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	6	6	CD	CD	_	9	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	14	14	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	9	nsubj	_	_
9	displayed	display	VBD	VBD	_	0	root	_	_
10	an	a	DT	DT	_	12	det	_	_
11	impaired	impaired	JJ	JJ	_	12	amod	_	_
12	ability	ability	NN	NN	_	9	dobj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	translocate	translocate	VB	VB	_	12	acl	_	_
15	NFeB	nfeb	NN	NN	_	21	compound	_	_
16	p65	p65	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	Rel-A	rel-a	NN	NN	_	21	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	following	follow	VBG	VBG	_	21	amod	_	_
21	activation	activation	NN	NN	_	14	dobj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	anti-CD3	anti-cd3	NN	NN	_	14	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	IL-2	il-2	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	made	make	VBN	VBN	_	0	root	_	_
5	despite	despite	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	cytoplasmic	cytoplasmic	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Rel-A	rel-a	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	detected	detect	VBD	VBD	_	0	root	_	_
4	abnormally	abnormally	RB	RB	_	3	advmod	_	_
5	low	low	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	signaling	signal	VBG	VBG	_	10	amod	_	_
10	molecules	molecule	NNS	NNS	_	6	nmod	_	_
11	T-cell	t-cell	NN	NN	_	16	compound	_	_
12	receptor	receptor	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	TCR	tcr	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	-zeta	-zeta	NN	NN	_	10	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	ZAP-70	zap-70	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	p56lck	p56lck	NN	NN	_	16	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	4	4	CD	CD	_	10	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	14	14	CD	CD	_	27	nummod	_	_
25	breast	breast	NN	NN	_	27	compound	_	_
26	cancer	cancer	NN	NN	_	27	compound	_	_
27	patients	patient	NNS	NNS	_	22	nmod	_	_
28	,	,	,	,	_	3	punct	_	_
29	i.e.	i.e.	FW	FW	_	3	advcl	_	_
30	,	,	,	,	_	3	punct	_	_
31	defects	defect	NNS	NNS	_	3	dobj	_	_
32	in	in	IN	IN	_	35	case	_	_
33	T-cell	t-cell	NN	NN	_	35	compound	_	_
34	signaling	signal	VBG	VBG	_	35	amod	_	_
35	molecules	molecule	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	6	6	CD	CD	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	14	14	CD	CD	_	8	nummod	_	_
8	patients	patient	NNS	NNS	_	4	nmod	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	exhibited	exhibit	VBD	VBD	_	0	root	_	_
11	an	a	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	dual	dual	JJ	JJ	_	18	amod	_	_
17	specificity	specificity	NN	NN	_	18	compound	_	_
18	phosphatase	phosphatase	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	map	map	NN	NN	_	22	compound	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	phosphatase-1	phosphatase-1	NN	NN	_	18	appos	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	MKP-1	mkp-1	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	10	punct	_	_

1	MKP-1	mkp-1	NN	NN	_	2	nsubj	_	_
2	inactivates	inactivate	VBZ	VBZ	_	0	root	_	_
3	MAP	map	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	therefore	therefore	RB	RB	_	8	advmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	interfere	interfere	VB	VB	_	2	conj	_	_
9	with	with	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	c-jun	c-jun	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	c-fos	c-fos	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	I	i	CD	CD	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	more	more	RBR	RBR	_	3	conj	_	_
6	signaling	signal	VBG	VBG	_	7	amod	_	_
7	molecules	molecule	NNS	NNS	_	3	dep	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	9	9	CD	CD	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	14	14	CD	CD	_	14	nummod	_	_
14	patients	patient	NNS	NNS	_	11	nmod	_	_
15	;	;	:	:	_	9	punct	_	_
16	however	however	RB	RB	_	9	advmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	only	only	RB	RB	_	19	advmod	_	_
19	3	3	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	21	nsubj	_	_
21	had	have	VBD	VBD	_	9	dep	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	21	dobj	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	exhibited	exhibit	VBD	VBD	_	23	acl:relcl	_	_
26	all	all	DT	DT	_	27	advmod	_	_
27	5	5	CD	CD	_	28	nummod	_	_
28	defects	defect	NNS	NNS	_	25	dobj	_	_
29	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	have	have	VBP	VBP	_	0	root	_	_
4	implications	implication	NNS	NNS	_	3	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	detection	detection	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	potentially	potentially	RB	RB	_	10	advmod	_	_
10	dysfunctional	dysfunctional	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	cancer	cancer	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	example	example	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	analysis	analysis	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	only	only	RB	RB	_	8	advmod	_	_
8	1	1	CD	CD	_	10	nummod	_	_
9	signaling	signal	VBG	VBG	_	10	amod	_	_
10	molecule	molecule	NN	NN	_	5	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	allow	allow	VB	VB	_	0	root	_	_
13	patients	patient	NNS	NNS	_	12	dobj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	significant	significant	JJ	JJ	_	16	amod	_	_
16	defects	defect	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	signaling	signaling	NN	NN	_	16	nmod	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	go	go	VB	VB	_	12	xcomp	_	_
22	unnoticed	unnoticed	JJ	JJ	_	21	xcomp	_	_
23	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	despite	despite	IN	IN	_	6	case	_	_
4	impaired	impaired	JJ	JJ	_	6	amod	_	_
5	Rel-A	rel-a	NN	NN	_	6	compound	_	_
6	translocation	translocation	NN	NN	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	11	nsubj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	capable	capable	JJ	JJ	_	0	root	_	_
12	of	of	IN	IN	_	13	mark	_	_
13	transcribing	transcribe	VBG	VBG	_	11	advcl	_	_
14	IL-2	il-2	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	11	punct	_	_

1	Impairments	impairment	NNS	NNS	_	10	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	translocation	translocation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Rel-B	rel-b	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-Rel	c-rel	NN	NN	_	6	conj	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	suggest	suggest	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	23	mark	_	_
12	the	the	DT	DT	_	15	det	_	_
13	NFKB	nfkb	NN	NN	_	15	compound	_	_
14	family	family	NN	NN	_	15	compound	_	_
15	members	member	NNS	NNS	_	23	nsubjpass	_	_
16	Rel-A	rel-a	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	Rel-B	rel-b	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	c-Rel	c-rel	NN	NN	_	16	conj	_	_
21	are	be	VBP	VBP	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	required	require	VBN	VBN	_	10	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	transcription	transcription	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	peripheral	peripheral	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	26	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	patients	patient	NNS	NNS	_	33	nmod	_	_
36	with	with	IN	IN	_	38	case	_	_
37	breast	breast	NN	NN	_	38	compound	_	_
38	cancer	cancer	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	4	nsubj	_	_
4	regulates	regulate	VBZ	VBZ	_	0	root	_	_
5	Fas	fas	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	CD95/APO-1	cd95/apo-1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	expression	expression	NN	NN	_	4	dobj	_	_
10	.	.	.	.	_	4	punct	_	_

1	Fas	fas	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CD95/APO-1	cd95/apo-1	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	transmembrane	transmembrane	JJ	JJ	_	8	amod	_	_
8	protein	protein	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	TNF/neuron	tnf/neuron	NN	NN	_	15	compound	_	_
12	growth	growth	NN	NN	_	15	compound	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Ligation	ligation	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Fas	fas	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	Abs	ab	NNS	NNS	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	Fas	fas	NN	NN	_	9	compound	_	_
9	ligand	ligand	NN	NN	_	6	conj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	FasL/CD95	fasl/cd95	NN	NN	_	12	compound	_	_
12	ligand	ligand	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	induces	induce	VBZ	VBZ	_	0	root	_	_
15	rapid	rapid	JJ	JJ	_	18	amod	_	_
16	apoptotic	apoptotic	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	death	death	NN	NN	_	14	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	variety	variety	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	types	type	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Despite	despite	IN	IN	_	2	case	_	_
2	progress	progress	NN	NN	_	15	nmod	_	_
3	in	in	IN	IN	_	4	mark	_	_
4	understanding	understand	VBG	VBG	_	2	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	death	death	NN	NN	_	7	compound	_	_
7	signals	signal	NNS	NNS	_	4	dobj	_	_
8	transduced	transduce	VBN	VBN	_	10	case	_	_
9	from	from	IN	IN	_	10	case	_	_
10	Fas	fas	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	little	little	JJ	JJ	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	known	know	VBN	VBN	_	0	root	_	_
16	with	with	IN	IN	_	17	case	_	_
17	regard	regard	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	26	nmod	_	_
23	Fas	fas	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	26	nsubjpass	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	regulated	regulate	VBN	VBN	_	20	acl:relcl	_	_
27	.	.	.	.	_	15	punct	_	_

1	Using	use	VBG	VBG	_	13	advcl	_	_
2	our	we	PRP$	PRP$	_	10	nmod:poss	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	established	established	JJ	JJ	_	10	amod	_	_
5	murine	murine	JJ	JJ	_	10	amod	_	_
6	T	t	NN	NN	_	10	compound	_	_
7	cell	cell	NN	NN	_	10	compound	_	_
8	hybridoma	hybridoma	NN	NN	_	10	compound	_	_
9	model	model	NN	NN	_	10	compound	_	_
10	A1.1	a1.1	NN	NN	_	1	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	show	show	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	24	mark	_	_
15	specific	specific	JJ	JJ	_	22	amod	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	C	c	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PKC	pkc	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	inhibitors	inhibitor	NNS	NNS	_	24	nsubj	_	_
23	could	could	MD	MD	_	24	aux	_	_
24	block	block	VB	VB	_	13	ccomp	_	_
25	activation-induced	activation-induced	JJ	JJ	_	27	amod	_	_
26	Fas	fas	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	apoptosis	apoptosis	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PKC	pkc	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PMA	pma	NN	NN	_	2	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	1-oleoyl-2-acetyl-sn-glycerol	1-oleoyl-2-acetyl-sn-glycerol	NN	NN	_	6	conj	_	_
9	could	could	MD	MD	_	10	aux	_	_
10	mimic	mimic	VB	VB	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	TCR	tcr	NN	NN	_	13	compound	_	_
13	signal	signal	NN	NN	_	10	dobj	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	10	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Fas	fas	NN	NN	_	17	nmod	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	not	not	RB	RB	_	19	cc	_	_
22	FasL	fasl	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	PKC-dependent	pkc-dependent	JJ	JJ	_	3	amod	_	_
2	Fas	fas	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	14	case	_	_
8	several	several	JJ	JJ	_	14	amod	_	_
9	murine	murine	JJ	JJ	_	14	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	human	human	JJ	JJ	_	9	conj	_	_
12	tumor	tumor	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	Since	since	IN	IN	_	18	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	inhibition	inhibition	NN	NN	_	18	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Ca2+	ca2+	NN	NN	_	6	compound	_	_
6	redistribution	redistribution	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	inhibitor	inhibitor	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	intracellular	intracellular	JJ	JJ	_	13	amod	_	_
12	Ca2+	ca2+	NN	NN	_	13	compound	_	_
13	mobilization	mobilization	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate	8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate	NN	NN	_	16	compound	_	_
16	hydrochloride	hydrochloride	NN	NN	_	9	appos	_	_
17	,	,	,	,	_	9	punct	_	_
18	inhibited	inhibit	VBD	VBD	_	29	advcl	_	_
19	TCR-induced	tcr-induced	JJ	JJ	_	20	amod	_	_
20	FasL	fasl	NN	NN	_	18	dobj	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	20	cc	_	_
23	Fas	fas	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	29	punct	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	29	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	Fas	fas	NN	NN	_	26	nmod	_	_
29	appears	appear	VBZ	VBZ	_	0	root	_	_
30	to	to	TO	TO	_	32	mark	_	_
31	be	be	VB	VB	_	32	cop	_	_
32	independent	independent	JJ	JJ	_	29	xcomp	_	_
33	of	of	IN	IN	_	35	case	_	_
34	Ca2+	ca2+	NN	NN	_	35	compound	_	_
35	mobilization	mobilization	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	29	punct	_	_

1	Significantly	significantly	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	expression	expression	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	newly	newly	RB	RB	_	7	advmod	_	_
7	identified	identify	VBN	VBN	_	9	amod	_	_
8	Fas-regulatory	fas-regulatory	JJ	JJ	_	9	amod	_	_
9	gene	gene	NN	NN	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	TDAG51	tdag51	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	dependent	dependent	JJ	JJ	_	14	xcomp	_	_
18	upon	upon	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	PKC	pkc	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	PKC	pkc	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	4	nsubj	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	Fas	fas	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	expressing	express	VBG	VBG	_	8	acl	_	_
10	wild-type	wild-type	JJ	JJ	_	11	amod	_	_
11	TDAG51	tdag51	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	Fas	fas	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	likely	likely	RB	RB	_	7	advmod	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	PKC	pkc	NN	NN	_	7	nmod	_	_
10	through	through	IN	IN	_	11	case	_	_
11	TDAG51	tdag51	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Transcription	transcription	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	minimal	minimal	JJ	JJ	_	5	amod	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	from	from	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	NF-IL6	nf-il6	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	1	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	CREB/ATF	creb/atf	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	SP1	sp1	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	13	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	U937	u937	NN	NN	_	20	compound	_	_
19	promonocytic	promonocytic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	NF-IL6	nf-il6	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	important	important	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	regulator	regulator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	genes	gene	NNS	NNS	_	6	nmod	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	NF-IL6	nf-il6	NN	NN	_	25	nsubj	_	_
16	is	be	VBZ	VBZ	_	25	cop	_	_
17	the	the	DT	DT	_	25	det	_	_
18	only	only	RB	RB	_	25	advmod	_	_
19	CCAAT/enhancer-binding	ccaat/enhancer-binding	JJ	JJ	_	25	amod	_	_
20	protein	protein	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	C/EBP	c/ebp	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	family	family	NN	NN	_	25	compound	_	_
25	member	member	NN	NN	_	6	conj	_	_
26	whose	whose	WP$	WP$	_	29	nmod:poss	_	_
27	steady-state	steady-state	JJ	JJ	_	29	amod	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	levels	level	NNS	NNS	_	30	nsubj	_	_
30	increase	increase	VBP	VBP	_	25	acl:relcl	_	_
31	upon	upon	IN	IN	_	32	case	_	_
32	activation	activation	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	1	1	CD	CD	_	25	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	NF-IL6	nf-il6	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
12	,	,	,	,	_	11	punct	_	_
13	at	at	IN	IN	_	16	advmod	_	_
14	least	least	JJS	JJS	_	13	mwe	_	_
15	in	in	IN	IN	_	16	case	_	_
16	part	part	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	for	for	IN	IN	_	19	case	_	_
19	induction	induction	NN	NN	_	11	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-IL6	nf-il6	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	19	nmod	_	_
23	following	follow	VBG	VBG	_	24	case	_	_
24	activation	activation	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	U937	u937	NN	NN	_	28	compound	_	_
27	promonocytic	promonocytic	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	104-bp	104-bp	JJ	JJ	_	8	amod	_	_
6	minimal	minimal	JJ	JJ	_	8	amod	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	region	region	NN	NN	_	3	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	NF-IL6	nf-il6	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	sufficient	sufficient	JJ	JJ	_	12	acl:relcl	_	_
16	for	for	IN	IN	_	20	case	_	_
17	basal	basal	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	activation-dependent	activation-dependent	JJ	JJ	_	17	conj	_	_
20	induction	induction	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	U937	u937	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	cAMP	camp	NN	NN	_	13	compound	_	_
9	response	response	NN	NN	_	13	compound	_	_
10	element-binding	element-binding	JJ	JJ	_	13	amod	_	_
11	protein/activation	protein/activation	NN	NN	_	13	compound	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	5	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CREB/ATF	creb/atf	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	Sp1	sp1	NN	NN	_	19	compound	_	_
19	families	family	NNS	NNS	_	13	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Each	each	JJ	JJ	_	2	amod	_	_
2	site	site	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	contributes	contribute	VBZ	VBZ	_	5	conj	_	_
8	independently	independently	RB	RB	_	7	advmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	transcription	transcription	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-IL6	nf-il6	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	U937	u937	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	p130	p130	NN	NN	_	9	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	p107	p107	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	pRb	prb	NN	NN	_	1	conj	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	differentially	differentially	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	proliferating	proliferate	VBG	VBG	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	during	during	IN	IN	_	17	case	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	cycle	cycle	NN	NN	_	17	compound	_	_
17	arrest	arrest	NN	NN	_	12	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	alpha-interferon	alpha-interferon	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	how	how	WRB	WRB	_	20	advmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	phosphorylation	phosphorylation	NN	NN	_	20	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	retinoblastoma	retinoblastoma	NN	NN	_	10	compound	_	_
10	family	family	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	pRb	prb	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	p107	p107	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	p130	p130	NN	NN	_	12	conj	_	_
18	)	)	-RRB-	-RRB-	_	12	punct	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	governed	govern	VBN	VBN	_	3	ccomp	_	_
21	in	in	IN	IN	_	25	case	_	_
22	individual	individual	JJ	JJ	_	25	amod	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	cycle	cycle	NN	NN	_	25	compound	_	_
25	phases	phase	NNS	NNS	_	20	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	Daudi	daudi	NN	NN	_	28	compound	_	_
28	B-cells	b-cell	NNS	NNS	_	25	nmod	_	_
29	during	during	IN	IN	_	32	case	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	cycle	cycle	NN	NN	_	32	compound	_	_
32	exit	exit	NN	NN	_	20	nmod	_	_
33	triggered	trigger	VBN	VBN	_	32	acl	_	_
34	by	by	IN	IN	_	35	case	_	_
35	alpha-interferon	alpha-interferon	NN	NN	_	33	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	alpha-IFN	alpha-ifn	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	3	punct	_	_

1	alpha-IFN	alpha-ifn	NN	NN	_	2	nsubj	_	_
2	causes	cause	VBZ	VBZ	_	0	root	_	_
3	dephosphorylation	dephosphorylation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	pRb	prb	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	3	cc	_	_
7	loss	loss	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	p130	p130	NN	NN	_	11	compound	_	_
10	phosphorylated	phosphorylated	JJ	JJ	_	11	amod	_	_
11	Form	form	NN	NN	_	7	nmod	_	_
12	3	3	CD	CD	_	11	nummod	_	_
13	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	change	change	NN	NN	_	12	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	p130	p130	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	response	response	NN	NN	_	11	dep	_	_
10	to	to	TO	TO	_	11	case	_	_
11	alpha-IFN	alpha-ifn	NN	NN	_	4	nmod	_	_
12	occurs	occur	VBZ	VBZ	_	0	root	_	_
13	before	before	IN	IN	_	18	mark	_	_
14	dephosphorylation	dephosphorylation	NN	NN	_	18	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	pRb	prb	NN	NN	_	14	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	complete	complete	JJ	JJ	_	12	advcl	_	_
19	because	because	IN	IN	_	25	mark	_	_
20	loss	loss	NN	NN	_	25	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	p130	p130	NN	NN	_	23	compound	_	_
23	Form	form	NN	NN	_	20	nmod	_	_
24	3	3	CD	CD	_	23	nummod	_	_
25	occurs	occur	VBZ	VBZ	_	12	advcl	_	_
26	throughout	throughout	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	cycle	cycle	NN	NN	_	25	nmod	_	_
30	prior	prior	JJ	JJ	_	33	case	_	_
31	to	to	TO	TO	_	30	mwe	_	_
32	complete	complete	JJ	JJ	_	33	amod	_	_
33	arrest	arrest	NN	NN	_	25	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	G1	g1	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	25	punct	_	_
37	whereas	whereas	IN	IN	_	25	dep	_	_
38	pRb	prb	NN	NN	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	dephosphorylated	dephosphorylate	VBN	VBN	_	25	parataxis	_	_
41	only	only	RB	RB	_	43	advmod	_	_
42	in	in	IN	IN	_	43	case	_	_
43	G1	g1	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	p107	p107	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	dephosphorylated	dephosphorylate	VBN	VBN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	then	then	RB	RB	_	10	advmod	_	_
10	depleted	deplete	VBN	VBN	_	6	conj	_	_
11	from	from	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	as	as	IN	IN	_	15	mark	_	_
14	they	they	PRP	PRP	_	15	nsubj	_	_
15	exit	exit	VBP	VBP	_	10	advcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	cycle	cycle	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	6	punct	_	_

1	p130	p130	NN	NN	_	11	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	predominantly	predominantly	RB	RB	_	5	advmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	Form	form	NN	NN	_	1	nmod	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	,	,	,	,	_	1	punct	_	_
8	and	and	CC	CC	_	1	cc	_	_
9	hypophosphorylated	hypophosphorylate	VBN	VBN	_	10	amod	_	_
10	pRb	prb	NN	NN	_	1	conj	_	_
11	bind	bind	VBP	VBP	_	0	root	_	_
12	an	a	DT	DT	_	16	det	_	_
13	E2F	e2f	NN	NN	_	16	compound	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	dobj	_	_
17	;	;	:	:	_	11	punct	_	_
18	p130	p130	NN	NN	_	19	nsubj	_	_
19	complexes	complex	NNS	NNS	_	11	parataxis	_	_
20	E2F-4	e2f-4	NN	NN	_	19	dobj	_	_
21	,	,	,	,	_	19	punct	_	_
22	whereas	whereas	IN	IN	_	19	dep	_	_
23	pRb	prb	NN	NN	_	24	nsubj	_	_
24	binds	bind	VBZ	VBZ	_	19	parataxis	_	_
25	both	both	CC	CC	_	26	cc:preconj	_	_
26	E2F-4	e2f-4	NN	NN	_	24	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	E2F-1	e2f-1	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	phosphorylated	phosphorylated	JJ	JJ	_	3	amod	_	_
3	forms	form	NNS	NNS	_	14	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	E2F-4	e2f-4	NN	NN	_	3	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	bind	bind	VBP	VBP	_	3	acl:relcl	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	E2F	e2f	NN	NN	_	12	compound	_	_
11	DNA	dna	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	different	different	JJ	JJ	_	0	root	_	_
15	from	from	IN	IN	_	17	case	_	_
16	hyperphosphorylated	hyperphosphorylate	VBN	VBN	_	17	amod	_	_
17	E2F-4	e2f-4	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	predominates	predominate	VBZ	VBZ	_	17	acl:relcl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	primary	primary	JJ	JJ	_	24	amod	_	_
23	hemopoietic	hemopoietic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	in	in	IN	IN	_	26	case	_	_
26	G0	g0	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	29	mark	_	_
4	although	although	IN	IN	_	13	mark	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	cycle	cycle	NN	NN	_	7	compound	_	_
7	arrest	arrest	NN	NN	_	13	nsubjpass	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	alpha-IFN	alpha-ifn	NN	NN	_	8	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	29	advcl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	part	part	NN	NN	_	17	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	formation	formation	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	complex	complex	NN	NN	_	17	nmod	_	_
21	containing	contain	VBG	VBG	_	20	acl	_	_
22	p130	p130	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	E2F-4	e2f-4	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	29	punct	_	_
26	alpha-IFN	alpha-ifn	NN	NN	_	29	nsubj	_	_
27	does	do	VBZ	VBZ	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	induce	induce	VB	VB	_	2	ccomp	_	_
30	hyperphosphorylation	hyperphosphorylation	NN	NN	_	29	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	E2F-4	e2f-4	NN	NN	_	30	nmod	_	_
33	,	,	,	,	_	30	punct	_	_
34	which	which	WDT	WDT	_	35	nsubj	_	_
35	characterizes	characterize	VBZ	VBZ	_	30	acl:relcl	_	_
36	primary	primary	JJ	JJ	_	38	amod	_	_
37	hemopoietic	hemopoietic	JJ	JJ	_	38	amod	_	_
38	cells	cell	NNS	NNS	_	35	dobj	_	_
39	in	in	IN	IN	_	40	case	_	_
40	G0	g0	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	Two-site	two-site	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
5	factor	factor	NN	NN	_	9	compound	_	_
6	of	of	IN	IN	_	9	amod	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	calcineurin	calcineurin	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	16	nsubj	_	_
3	belonging	belong	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	15	case	_	_
5	the	the	DT	DT	_	15	det	_	_
6	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
7	factor	factor	NN	NN	_	15	compound	_	_
8	of	of	IN	IN	_	15	amod	_	_
9	activated	activate	VBN	VBN	_	15	amod	_	_
10	T	t	NN	NN	_	15	compound	_	_
11	cells	cell	NNS	NNS	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	NFAT	nfat	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	family	family	NN	NN	_	3	nmod	_	_
16	regulate	regulate	VBP	VBP	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	other	other	JJ	JJ	_	25	amod	_	_
24	inducible	inducible	JJ	JJ	_	25	amod	_	_
25	genes	gene	NNS	NNS	_	21	conj	_	_
26	during	during	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	response	response	NN	NN	_	16	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	functions	function	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NFAT	nfat	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	directly	directly	RB	RB	_	8	advmod	_	_
8	controlled	control	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	calcium-	calcium-	NN	NN	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	calmodulin-dependent	calmodulin-dependent	JJ	JJ	_	11	conj	_	_
14	phosphatase	phosphatase	NN	NN	_	15	compound	_	_
15	calcineurin	calcineurin	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	binding	binding	NN	NN	_	13	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	calcineurin	calcineurin	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	NFAT	nfat	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	substantially	substantially	RB	RB	_	13	advmod	_	_
13	increased	increase	VBN	VBN	_	3	ccomp	_	_
14	when	when	WRB	WRB	_	17	advmod	_	_
15	calcineurin	calcineurin	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	activated	activate	VBN	VBN	_	13	advcl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	calmodulin	calmodulin	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	calcium	calcium	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	FK506.FKBP12	fk506.fkbp12	NN	NN	_	3	compound	_	_
2	drug-immunophilin	drug-immunophilin	NN	NN	_	3	compound	_	_
3	complexes	complex	NNS	NNS	_	4	nsubj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	interaction	interaction	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NFAT	nfat	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	activated	activate	VBN	VBN	_	11	amod	_	_
11	calcineurin	calcineurin	NN	NN	_	6	nmod	_	_
12	much	much	RB	RB	_	13	advmod	_	_
13	more	more	RBR	RBR	_	14	advmod	_	_
14	effectively	effectively	RB	RB	_	4	advmod	_	_
15	than	than	IN	IN	_	17	mark	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	inhibited	inhibit	VBD	VBD	_	14	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	interaction	interaction	NN	NN	_	17	dobj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	inactive	inactive	JJ	JJ	_	22	amod	_	_
22	calcineurin	calcineurin	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	4	punct	_	_
24	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
25	that	that	IN	IN	_	33	mark	_	_
26	part	part	NN	NN	_	33	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	interaction	interaction	NN	NN	_	26	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	activated	activate	VBN	VBN	_	32	amod	_	_
32	calcineurin	calcineurin	NN	NN	_	29	nmod	_	_
33	involved	involve	VBD	VBD	_	24	ccomp	_	_
34	the	the	DT	DT	_	37	det	_	_
35	enzyme	enzyme	NN	NN	_	37	compound	_	_
36	active	active	JJ	JJ	_	37	amod	_	_
37	site	site	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	NFAT	nfat	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	targeted	target	VBN	VBN	_	4	ccomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	inactive	inactive	JJ	JJ	_	11	amod	_	_
11	calcineurin	calcineurin	NN	NN	_	8	nmod	_	_
12	at	at	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	region	region	NN	NN	_	11	nmod	_	_
15	distinct	distinct	JJ	JJ	_	14	amod	_	_
16	from	from	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	calcineurin	calcineurin	NN	NN	_	20	compound	_	_
19	active	active	JJ	JJ	_	20	amod	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	Aramburu	Aramburu	NNP	NNP	_	24	compound	_	_
23	,	,	,	,	_	24	punct	_	_
24	J.	J.	NNP	NNP	_	8	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	Garcia-Cozar	Garcia-Cozar	NNP	NNP	_	29	compound	_	_
27	,	,	,	,	_	29	punct	_	_
28	F.	F.	NNP	NNP	_	29	appos	_	_
29	J.	J.	NNP	NNP	_	24	conj	_	_
30	,	,	,	,	_	24	punct	_	_
31	Raghavan	Raghavan	NNP	NNP	_	33	compound	_	_
32	,	,	,	,	_	33	punct	_	_
33	A.	A.	NNP	NNP	_	24	conj	_	_
34	,	,	,	,	_	24	punct	_	_
35	Okamura	Okamura	NNP	NNP	_	37	compound	_	_
36	,	,	,	,	_	37	punct	_	_
37	H.	H.	NNP	NNP	_	24	conj	_	_
38	,	,	,	,	_	24	punct	_	_
39	Rao	Rao	NNP	NNP	_	41	compound	_	_
40	,	,	,	,	_	41	punct	_	_
41	A.	A.	NNP	NNP	_	24	conj	_	_
42	,	,	,	,	_	24	punct	_	_
43	and	and	CC	CC	_	24	cc	_	_
44	Hogan	Hogan	NNP	NNP	_	47	compound	_	_
45	,	,	,	,	_	47	punct	_	_
46	P.	P.	NNP	NNP	_	47	appos	_	_
47	G.	G.	NNP	NNP	_	24	conj	_	_
48	(	(	-LRB-	-LRB-	_	24	punct	_	_
49	1998	1998	CD	CD	_	24	dep	_	_
50	)	)	-RRB-	-RRB-	_	24	punct	_	_
51	Mol.	Mol.	NNP	NNP	_	52	compound	_	_
52	Cell	Cell	NNP	NNP	_	24	dep	_	_
53	1	1	CD	CD	_	52	nummod	_	_
54	,	,	,	,	_	24	punct	_	_
55	627-637	627-637	CD	CD	_	24	amod	_	_
56	)	)	-RRB-	-RRB-	_	24	punct	_	_
57	;	;	:	:	_	4	punct	_	_
58	this	this	DT	DT	_	59	det	_	_
59	region	region	NN	NN	_	62	nsubjpass	_	_
60	is	be	VBZ	VBZ	_	62	auxpass	_	_
61	also	also	RB	RB	_	62	advmod	_	_
62	involved	involve	VBN	VBN	_	4	parataxis	_	_
63	in	in	IN	IN	_	65	case	_	_
64	NFAT	nfat	NN	NN	_	65	compound	_	_
65	binding	binding	NN	NN	_	62	nmod	_	_
66	to	to	TO	TO	_	68	case	_	_
67	activated	activate	VBN	VBN	_	68	amod	_	_
68	calcineurin	calcineurin	NN	NN	_	65	nmod	_	_
69	,	,	,	,	_	62	punct	_	_
70	since	since	IN	IN	_	73	mark	_	_
71	binding	binding	NN	NN	_	73	nsubjpass	_	_
72	is	be	VBZ	VBZ	_	73	auxpass	_	_
73	inhibited	inhibit	VBN	VBN	_	62	advcl	_	_
74	by	by	IN	IN	_	77	case	_	_
75	an	a	DT	DT	_	77	det	_	_
76	NFAT	nfat	NN	NN	_	77	compound	_	_
77	peptide	peptide	NN	NN	_	73	nmod	_	_
78	spanning	span	VBG	VBG	_	77	acl	_	_
79	the	the	DT	DT	_	82	det	_	_
80	calcineurin	calcineurin	NN	NN	_	82	compound	_	_
81	docking	docking	NN	NN	_	82	compound	_	_
82	site	site	NN	NN	_	78	dobj	_	_
83	on	on	IN	IN	_	84	case	_	_
84	NFAT	nfat	NN	NN	_	82	nmod	_	_
85	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	interacting	interact	VBG	VBG	_	3	amod	_	_
3	surfaces	surface	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	located	located	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	catalytic	catalytic	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	calcineurin	calcineurin	NN	NN	_	14	compound	_	_
13	A	a	NN	NN	_	14	compound	_	_
14	chain	chain	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	on	on	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	86-amino	86-amino	NN	NN	_	20	compound	_	_
19	acid	acid	NN	NN	_	20	compound	_	_
20	fragment	fragment	NN	NN	_	9	conj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	NFAT	nfat	NN	NN	_	25	compound	_	_
24	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
25	domain	domain	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	NFAT	nfat	NN	NN	_	9	nsubjpass	_	_
2	binding	binding	NN	NN	_	1	dep	_	_
3	to	to	TO	TO	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	calcineurin	calcineurin	NN	NN	_	7	compound	_	_
6	catalytic	catalytic	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	calcineurin	calcineurin	NN	NN	_	14	compound	_	_
13	autoinhibitory	autoinhibitory	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	RII	rii	NN	NN	_	19	compound	_	_
18	substrate	substrate	NN	NN	_	19	compound	_	_
19	peptide	peptide	NN	NN	_	14	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	bind	bind	VBP	VBP	_	14	acl:relcl	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	calcineurin	calcineurin	NN	NN	_	27	compound	_	_
26	active	active	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	14	punct	_	_
29	as	as	RB	RB	_	14	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	by	by	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	NFAT	nfat	NN	NN	_	37	compound	_	_
35	docking	docking	NN	NN	_	37	compound	_	_
36	site	site	NN	NN	_	37	compound	_	_
37	peptide	peptide	NN	NN	_	14	conj	_	_
38	,	,	,	,	_	37	punct	_	_
39	which	which	WDT	WDT	_	40	nsubj	_	_
40	binds	bind	VBZ	VBZ	_	37	acl:relcl	_	_
41	to	to	TO	TO	_	43	case	_	_
42	a	a	DT	DT	_	43	det	_	_
43	region	region	NN	NN	_	40	nmod	_	_
44	of	of	IN	IN	_	45	case	_	_
45	calcineurin	calcineurin	NN	NN	_	43	nmod	_	_
46	distinct	distinct	JJ	JJ	_	43	amod	_	_
47	from	from	IN	IN	_	50	case	_	_
48	the	the	DT	DT	_	50	det	_	_
49	active	active	JJ	JJ	_	50	amod	_	_
50	site	site	NN	NN	_	46	nmod	_	_
51	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	,	,	,	,	_	11	punct	_	_
5	in	in	IN	IN	_	7	case	_	_
6	resting	rest	VBG	VBG	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	NFAT	nfat	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	targeted	target	VBN	VBN	_	2	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	region	region	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	calcineurin	calcineurin	NN	NN	_	19	compound	_	_
18	catalytic	catalytic	JJ	JJ	_	19	amod	_	_
19	domain	domain	NN	NN	_	14	nmod	_	_
20	that	that	WDT	WDT	_	23	nsubj	_	_
21	does	do	VBZ	VBZ	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	overlap	overlap	VB	VB	_	14	acl:relcl	_	_
24	the	the	DT	DT	_	27	det	_	_
25	calcineurin	calcineurin	NN	NN	_	27	compound	_	_
26	active	active	JJ	JJ	_	27	amod	_	_
27	site	site	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	2	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	13	nmod	_	_
4	,	,	,	,	_	13	punct	_	_
5	displacement	displacement	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	autoinhibitory	autoinhibitory	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	calmodulin	calmodulin	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	5	nmod	_	_
13	allows	allow	VBZ	VBZ	_	0	root	_	_
14	NFAT	nfat	NN	NN	_	13	dobj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	bind	bind	VB	VB	_	13	xcomp	_	_
17	additionally	additionally	RB	RB	_	16	advmod	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	calcineurin	calcineurin	NN	NN	_	22	compound	_	_
21	active	active	JJ	JJ	_	22	amod	_	_
22	site	site	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	thus	thus	RB	RB	_	25	advmod	_	_
25	positioning	position	VBG	VBG	_	13	xcomp	_	_
26	NFAT	nfat	NN	NN	_	25	dobj	_	_
27	for	for	IN	IN	_	29	case	_	_
28	immediate	immediate	JJ	JJ	_	29	amod	_	_
29	dephosphorylation	dephosphorylation	NN	NN	_	25	nmod	_	_
30	at	at	IN	IN	_	33	case	_	_
31	functional	functional	JJ	JJ	_	33	amod	_	_
32	phosphoserine	phosphoserine	NN	NN	_	33	compound	_	_
33	residues	residue	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	p56lck-independent	p56lck-independent	JJ	JJ	_	3	amod	_	_
3	pathway	pathway	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	CD2	cd2	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	3	nmod	_	_
7	involves	involve	VBZ	VBZ	_	3	dep	_	_
8	Jun	jun	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	7	dobj	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	p56	p56	NN	NN	_	7	compound	_	_
3	Src	src	NN	NN	_	7	compound	_	_
4	family	family	NN	NN	_	7	compound	_	_
5	non-receptor	non-receptor	JJ	JJ	_	7	amod	_	_
6	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	10	nsubjpass	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	shown	show	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	critical	critical	JJ	JJ	_	10	xcomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocyte	lymphocyte	NN	NN	_	13	nmod	_	_
17	differentiation	differentiation	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	activation	activation	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	10	punct	_	_

1	Hence	hence	RB	RB	_	15	advmod	_	_
2	in	in	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	dep	_	_
4	absence	absence	NN	NN	_	6	dep	_	_
5	of	of	IN	IN	_	6	case	_	_
6	p56	p56	NN	NN	_	15	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	11	nmod:npmod	_	_
11	triggered	triggered	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	15	nsubj	_	_
13	does	do	VBZ	VBZ	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	occur	occur	VB	VB	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	for	for	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	CD2-based	cd2-based	JJ	JJ	_	9	amod	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	4	nmod	_	_
10	which	which	WDT	WDT	_	23	nsubj	_	_
11	,	,	,	,	_	23	punct	_	_
12	in	in	IN	IN	_	15	case	_	_
13	contrast	contrast	NN	NN	_	15	dep	_	_
14	to	to	TO	TO	_	15	case	_	_
15	that	that	DT	DT	_	23	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	T	t	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	independent	independent	JJ	JJ	_	9	acl:relcl	_	_
24	of	of	IN	IN	_	25	case	_	_
25	p56	p56	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	CD2-mediated	cd2-mediated	JJ	JJ	_	3	amod	_	_
2	interleukin-2	interleukin-2	NN	NN	_	3	compound	_	_
3	production	production	NN	NN	_	4	nsubj	_	_
4	occurs	occur	VBZ	VBZ	_	0	root	_	_
5	via	via	IN	IN	_	6	case	_	_
6	activation	activation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Jun	jun	NN	NN	_	9	compound	_	_
9	kinase	kinase	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	9	nmod	_	_
13	lacking	lack	VBG	VBG	_	12	acl	_	_
14	p56	p56	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Jun	jun	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	4	nsubj	_	_
3	then	then	RB	RB	_	4	advmod	_	_
4	facilitates	facilitate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	binding	binding	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	c-Jun/c-Fos	c-jun/c-fos	NN	NN	_	9	compound	_	_
9	heterodimers	heterodimer	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	AP-1	ap-1	NN	NN	_	14	compound	_	_
13	consensus	consensus	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	subsequent	subsequent	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	6	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	interleukin-2	interleukin-2	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	elucidate	elucidate	VBP	VBP	_	0	root	_	_
4	differences	difference	NNS	NNS	_	3	dobj	_	_
5	between	between	IN	IN	_	10	case	_	_
6	TCR	tcr	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD2	cd2	NN	NN	_	6	conj	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	4	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	same	same	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	4	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Interleukin-6	interleukin-6	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	hemorrhagic	hemorrhagic	JJ	JJ	_	5	amod	_	_
5	shock	shock	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	accompanied	accompany	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	neutrophil	neutrophil	NN	NN	_	10	compound	_	_
10	recruitment	recruitment	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	lung	lung	NN	NN	_	13	compound	_	_
13	injury	injury	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	Hemorrhagic	hemorrhagic	JJ	JJ	_	2	amod	_	_
2	shock	shock	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	HS	hs	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	initiates	initiate	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	inflammatory	inflammatory	JJ	JJ	_	9	amod	_	_
9	cascade	cascade	NN	NN	_	6	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	includes	include	VBZ	VBZ	_	9	acl:relcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cytokines	cytokine	NNS	NNS	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	recruitment	recruitment	NN	NN	_	13	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	17	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMN	pmn	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	6	cc	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	progress	progress	VB	VB	_	6	conj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	organ	organ	JJ	JJ	_	28	amod	_	_
28	failure	failure	NN	NN	_	25	nmod	_	_
29	,	,	,	,	_	25	punct	_	_
30	inducing	induce	VBG	VBG	_	25	xcomp	_	_
31	acute	acute	JJ	JJ	_	34	amod	_	_
32	respiratory	respiratory	JJ	JJ	_	34	amod	_	_
33	distress	distress	NN	NN	_	34	compound	_	_
34	syndrome	syndrome	NN	NN	_	30	dobj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	ARDS	ards	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	21	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	interleukin-6	interleukin-6	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-6	il-6	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	contributes	contribute	VBZ	VBZ	_	4	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	PMN	pmn	NN	NN	_	13	compound	_	_
13	infiltration	infiltration	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	lung	lung	NN	NN	_	16	compound	_	_
16	damage	damage	NN	NN	_	13	conj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	HS	hs	NN	NN	_	10	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	examined	examine	VBD	VBD	_	0	root	_	_
22	the	the	DT	DT	_	23	det	_	_
23	lungs	lung	NNS	NNS	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	rats	rat	NNS	NNS	_	23	nmod	_	_
26	subjected	subject	VBN	VBN	_	25	acl	_	_
27	to	to	TO	TO	_	31	case	_	_
28	unresuscitated	unresuscitated	JJ	JJ	_	31	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	resuscitated	resuscitate	VBN	VBN	_	28	conj	_	_
31	HS	hs	NN	NN	_	26	nmod	_	_
32	for	for	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	production	production	NN	NN	_	21	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	IL-6	il-6	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	34	cc	_	_
38	activation	activation	NN	NN	_	34	conj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	Stat3	stat3	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	21	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	semiquantitative	semiquantitative	JJ	JJ	_	3	amod	_	_
3	RT-PCR	rt-pcr	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	found	find	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	striking	striking	JJ	JJ	_	9	amod	_	_
9	increase	increase	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	IL-6	il-6	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	9	nmod	_	_
14	only	only	RB	RB	_	17	advmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	resuscitated	resuscitated	JJ	JJ	_	17	amod	_	_
17	HS	hs	NN	NN	_	6	nmod	_	_
18	,	,	,	,	_	6	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	peak	peak	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	6	nmod	_	_
22	observed	observe	VBN	VBN	_	21	acl	_	_
23	1	1	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	22	nmod	_	_
25	after	after	IN	IN	_	24	case	_	_
26	initiation	initiation	NN	NN	_	24	dep	_	_
27	of	of	IN	IN	_	28	case	_	_
28	resuscitation	resuscitation	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	IL-6	il-6	NN	NN	_	4	compound	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	11	case	_	_
8	bronchial	bronchial	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	alveolar	alveolar	JJ	JJ	_	8	conj	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	extracts	extract	NNS	NNS	_	4	nmod	_	_
8	from	from	IN	IN	_	10	case	_	_
9	shock	shock	NN	NN	_	10	compound	_	_
10	lungs	lung	NNS	NNS	_	7	nmod	_	_
11	exhibited	exhibit	VBD	VBD	_	0	root	_	_
12	an	a	DT	DT	_	13	det	_	_
13	increase	increase	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	Stat3	stat3	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	kinetics	kinetics	NN	NN	_	11	nmod	_	_
19	similar	similar	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	IL-6	il-6	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	In	in	FW	FW	_	5	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	DNA	dna	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	6	nsubj	_	_
6	determined	determine	VBD	VBD	_	0	root	_	_
7	Stat3	stat3	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	predominantly	predominantly	RB	RB	_	6	advmod	_	_
10	within	within	IN	IN	_	11	case	_	_
11	alveoli	alveolus	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Intratracheal	intratracheal	JJ	JJ	_	2	amod	_	_
2	instillation	instillation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IL-6	il-6	NN	NN	_	2	nmod	_	_
5	alone	alone	RB	RB	_	4	advmod	_	_
6	into	into	IN	IN	_	8	case	_	_
7	normal	normal	JJ	JJ	_	8	amod	_	_
8	rats	rat	NNS	NNS	_	2	nmod	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	PMN	pmn	NN	NN	_	12	compound	_	_
12	infiltration	infiltration	NN	NN	_	9	nmod	_	_
13	into	into	IN	IN	_	15	case	_	_
14	lung	lung	NN	NN	_	15	compound	_	_
15	interstitium	interstitium	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	alveoli	alveolus	NNS	NNS	_	15	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	marked	marked	JJ	JJ	_	20	amod	_	_
20	elevation	elevation	NN	NN	_	12	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	bronchoalveolar	bronchoalveolar	JJ	JJ	_	24	amod	_	_
23	lavage	lavage	NN	NN	_	24	compound	_	_
24	cellularity	cellularity	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	and	and	CC	CC	_	12	cc	_	_
27	increased	increase	VBN	VBN	_	29	amod	_	_
28	wet-to-dry	wet-to-dry	JJ	JJ	_	29	amod	_	_
29	ratio	ratio	NN	NN	_	12	conj	_	_
30	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	IL-6	il-6	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Stat3	stat3	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	conj	_	_
10	occur	occur	VBP	VBP	_	3	ccomp	_	_
11	early	early	RB	RB	_	10	advmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	HS	hs	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	contribute	contribute	VB	VB	_	10	conj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	PMN-mediated	pmn-mediated	JJ	JJ	_	20	amod	_	_
19	lung	lung	NN	NN	_	20	compound	_	_
20	injury	injury	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	including	include	VBG	VBG	_	23	case	_	_
23	ARDS	ards	NN	NN	_	20	nmod	_	_
24	after	after	IN	IN	_	25	case	_	_
25	HS	hs	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	CD30	cd30	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	CD40-inducible	cd40-inducible	JJ	JJ	_	5	amod	_	_
5	molecule	molecule	NN	NN	_	0	root	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	negatively	negatively	RB	RB	_	8	advmod	_	_
8	regulates	regulate	VBZ	VBZ	_	5	acl:relcl	_	_
9	CD40-mediated	cd40-mediated	JJ	JJ	_	12	amod	_	_
10	immunoglobulin	immunoglobulin	NN	NN	_	12	compound	_	_
11	class	class	NN	NN	_	12	compound	_	_
12	switching	switching	NN	NN	_	8	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	non-antigen-selected	non-antigen-selected	JJ	JJ	_	17	amod	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
4	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
5	model	model	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	germinal	germinal	JJ	JJ	_	9	amod	_	_
8	center	center	NN	NN	_	9	compound	_	_
9	maturation	maturation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	CL-01	cl-01	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	appos	_	_
14	,	,	,	,	_	9	punct	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	investigate	investigate	VB	VB	_	2	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	CD30	cd30	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	differentiation	differentiation	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	CL-01	cl-01	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	IgM+	igm+	JJ	JJ	_	6	amod	_	_
5	IgD+	igd+	JJ	JJ	_	6	amod	_	_
6	CD30+	cd30+	JJ	JJ	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	switch	switch	VBP	VBP	_	6	conj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	IgG	igg	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	IgA	iga	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	IgE	ige	NN	NN	_	10	conj	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	exposed	expose	VBN	VBN	_	8	advcl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	CD40L	cd40l	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-4	il-4	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	Switching	switching	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	hampered	hamper	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	CD30	cd30	NN	NN	_	6	compound	_	_
6	coengagement	coengagement	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	possibly	possibly	RB	RB	_	10	advmod	_	_
9	through	through	IN	IN	_	10	case	_	_
10	interference	interference	NN	NN	_	3	nmod	_	_
11	with	with	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	CD40-mediated	cd40-mediated	JJ	JJ	_	16	amod	_	_
14	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	16	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	downstream	downstream	JJ	JJ	_	20	amod	_	_
19	C(H)	c(h)	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	physiological	physiological	JJ	JJ	_	3	amod	_	_
3	relevance	relevance	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	phenomenon	phenomenon	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	emphasized	emphasize	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	similar	similar	JJ	JJ	_	12	amod	_	_
11	CD30-mediated	cd30-mediated	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	naive	naive	JJ	JJ	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Expression	expression	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD30	cd30	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	CD40L	cd40l	NN	NN	_	8	nmod	_	_
11	but	but	CC	CC	_	8	cc	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	inhibited	inhibit	VBN	VBN	_	8	conj	_	_
14	by	by	IN	IN	_	18	case	_	_
15	B	b	NN	NN	_	18	compound	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	coengagement	coengagement	NN	NN	_	13	nmod	_	_
19	and/or	and/or	CC	CC	_	18	cc	_	_
20	exposure	exposure	NN	NN	_	18	conj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	IL-6	il-6	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-12	il-12	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CD30	cd30	NN	NN	_	7	nsubj	_	_
6	critically	critically	RB	RB	_	7	advmod	_	_
7	regulates	regulate	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD40-mediated	cd40-mediated	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	non-antigen-selected	non-antigen-selected	JJ	JJ	_	15	amod	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Mn	mn	NN	NN	_	4	compound	_	_
4	SOD	sod	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
8	without	without	IN	IN	_	11	case	_	_
9	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	1	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	mutant	mutant	JJ	JJ	_	15	amod	_	_
15	endotoxin	endotoxin	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Endotoxin	endotoxin	NN	NN	_	3	nsubj	_	_
2	selectively	selectively	RB	RB	_	3	advmod	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	monocyte	monocyte	NN	NN	_	7	compound	_	_
5	Mn	mn	NN	NN	_	7	compound	_	_
6	superoxide	superoxide	NN	NN	_	7	compound	_	_
7	dismutase	dismutase	NN	NN	_	3	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	SOD	sod	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	without	without	IN	IN	_	12	mark	_	_
12	affecting	affect	VBG	VBG	_	3	advcl	_	_
13	levels	level	NNS	NNS	_	12	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Cu	cu	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	Zn	zn	NN	NN	_	18	compound	_	_
18	SOD	sod	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	catalase	catalase	NN	NN	_	15	conj	_	_
21	,	,	,	,	_	15	punct	_	_
22	or	or	CC	CC	_	15	cc	_	_
23	glutathione	glutathione	NN	NN	_	24	compound	_	_
24	peroxidase	peroxidase	NN	NN	_	15	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	about	about	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	structure-activity	structure-activity	JJ	JJ	_	9	amod	_	_
9	relationship	relationship	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mechanism	mechanism	NN	NN	_	9	conj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	which	which	WDT	WDT	_	16	nmod	_	_
15	endotoxin	endotoxin	NN	NN	_	16	nsubj	_	_
16	induces	induce	VBZ	VBZ	_	12	acl:relcl	_	_
17	Mn	mn	JJ	JJ	_	18	amod	_	_
18	SOD	sod	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	26	mark	_	_
7	a	a	DT	DT	_	11	det	_	_
8	mutant	mutant	JJ	JJ	_	11	amod	_	_
9	Escherichia	escherichia	FW	FW	_	11	compound	_	_
10	coli	coli	FW	FW	_	11	compound	_	_
11	endotoxin	endotoxin	NN	NN	_	26	nsubj	_	_
12	lacking	lack	VBG	VBG	_	11	acl	_	_
13	myristoyl	myristoyl	NN	NN	_	15	compound	_	_
14	fatty	fatty	NN	NN	_	15	compound	_	_
15	acid	acid	NN	NN	_	12	dobj	_	_
16	at	at	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	3'	3'	JJ	JJ	_	20	amod	_	_
19	R-3-hydroxymyristate	r-3-hydroxymyristate	NN	NN	_	20	compound	_	_
20	position	position	NN	NN	_	12	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	lipid	lipid	NN	NN	_	25	compound	_	_
24	A	a	NN	NN	_	25	compound	_	_
25	moiety	moiety	NN	NN	_	20	nmod	_	_
26	retained	retain	VBD	VBD	_	5	ccomp	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	full	full	JJ	JJ	_	29	amod	_	_
29	capacity	capacity	NN	NN	_	26	dobj	_	_
30	to	to	TO	TO	_	29	acl	_	_
31	coagulate	coagulate	VB	VB	_	30	dep	_	_
32	Limulus	limulus	JJ	JJ	_	34	amod	_	_
33	amoebocyte	amoebocyte	NN	NN	_	34	compound	_	_
34	lysate	lysate	NN	NN	_	30	dobj	_	_
35	compared	compare	VBN	VBN	_	41	case	_	_
36	with	with	IN	IN	_	41	case	_	_
37	the	the	DT	DT	_	41	det	_	_
38	wild-type	wild-type	JJ	JJ	_	41	amod	_	_
39	E.	e.	FW	FW	_	41	compound	_	_
40	coli	coli	FW	FW	_	41	compound	_	_
41	endotoxin	endotoxin	NN	NN	_	26	advcl	_	_
42	and	and	CC	CC	_	26	cc	_	_
43	markedly	markedly	RB	RB	_	44	advmod	_	_
44	stimulated	stimulate	VBD	VBD	_	26	conj	_	_
45	the	the	DT	DT	_	46	det	_	_
46	activation	activation	NN	NN	_	44	dobj	_	_
47	of	of	IN	IN	_	51	case	_	_
48	human	human	JJ	JJ	_	51	amod	_	_
49	monocyte	monocyte	NN	NN	_	51	compound	_	_
50	nuclear	nuclear	JJ	JJ	_	51	amod	_	_
51	factor-kappaB	factor-kappab	NN	NN	_	46	nmod	_	_
52	and	and	CC	CC	_	46	cc	_	_
53	the	the	DT	DT	_	54	det	_	_
54	induction	induction	NN	NN	_	46	conj	_	_
55	of	of	IN	IN	_	58	case	_	_
56	Mn	mn	NN	NN	_	58	compound	_	_
57	SOD	sod	NN	NN	_	58	compound	_	_
58	mRNA	mrna	NN	NN	_	54	nmod	_	_
59	and	and	CC	CC	_	46	cc	_	_
60	enzyme	enzyme	NN	NN	_	61	compound	_	_
61	activity	activity	NN	NN	_	46	conj	_	_
62	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	in	in	IN	IN	_	8	case	_	_
4	contrast	contrast	NN	NN	_	8	dep	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	wild-type	wild-type	JJ	JJ	_	8	amod	_	_
8	endotoxin	endotoxin	NN	NN	_	11	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	it	it	PRP	PRP	_	11	nsubj	_	_
11	failed	fail	VBD	VBD	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	induce	induce	VB	VB	_	11	xcomp	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	production	production	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	tumor	tumor	NN	NN	_	19	compound	_	_
18	necrosis	necrosis	NN	NN	_	19	compound	_	_
19	factor-alpha	factor-alpha	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	macrophage	macrophage	NN	NN	_	23	compound	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	protein-1alpha	protein-1alpha	NN	NN	_	19	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
26	and	and	CC	CC	_	11	cc	_	_
27	did	do	VBD	VBD	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	induce	induce	VB	VB	_	11	conj	_	_
30	the	the	DT	DT	_	31	det	_	_
31	phosphorylation	phosphorylation	NN	NN	_	29	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	translocation	translocation	NN	NN	_	31	conj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	mitogen-activated	mitogen-activated	JJ	JJ	_	38	amod	_	_
37	protein	protein	NN	NN	_	38	compound	_	_
38	kinase	kinase	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	30	mark	_	_
5	1	1	LS	LS	_	30	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	lipid	lipid	NN	NN	_	11	compound	_	_
8	A	a	NN	NN	_	11	compound	_	_
9	myristoyl	myristoyl	NN	NN	_	11	compound	_	_
10	fatty	fatty	NN	NN	_	11	compound	_	_
11	acid	acid	NN	NN	_	30	nsubj	_	_
12	,	,	,	,	_	30	punct	_	_
13	although	although	IN	IN	_	16	mark	_	_
14	it	it	PRP	PRP	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	important	important	JJ	JJ	_	30	dep	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	induction	induction	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	amod	_	_
21	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
22	cytokine	cytokine	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	19	dep	_	_
24	by	by	IN	IN	_	26	case	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
27	,	,	,	,	_	30	punct	_	_
28	is	be	VBZ	VBZ	_	30	cop	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
31	for	for	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	induction	induction	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	Mn	mn	NN	NN	_	36	compound	_	_
36	SOD	sod	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	30	punct	_	_
38	2	2	CD	CD	_	49	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	endotoxin-mediated	endotoxin-mediated	JJ	JJ	_	41	amod	_	_
41	induction	induction	NN	NN	_	49	nsubjpass	_	_
42	of	of	IN	IN	_	44	case	_	_
43	Mn	mn	NN	NN	_	44	compound	_	_
44	SOD	sod	NN	NN	_	41	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	inflammatory	inflammatory	JJ	JJ	_	47	amod	_	_
47	cytokines	cytokine	NNS	NNS	_	44	conj	_	_
48	are	be	VBP	VBP	_	49	auxpass	_	_
49	regulated	regulate	VBN	VBN	_	30	ccomp	_	_
50	,	,	,	,	_	49	punct	_	_
51	at	at	IN	IN	_	54	advmod	_	_
52	least	least	JJS	JJS	_	51	mwe	_	_
53	in	in	IN	IN	_	54	case	_	_
54	part	part	NN	NN	_	49	nmod	_	_
55	,	,	,	,	_	49	punct	_	_
56	through	through	IN	IN	_	60	case	_	_
57	different	different	JJ	JJ	_	60	amod	_	_
58	signal	signal	NN	NN	_	60	compound	_	_
59	transduction	transduction	NN	NN	_	60	compound	_	_
60	pathways	pathway	NNS	NNS	_	49	nmod	_	_
61	,	,	,	,	_	30	punct	_	_
62	and	and	CC	CC	_	30	cc	_	_
63	3	3	CD	CD	_	81	dep	_	_
64	)	)	-RRB-	-RRB-	_	63	punct	_	_
65	failure	failure	NN	NN	_	81	nsubj	_	_
66	of	of	IN	IN	_	69	case	_	_
67	the	the	DT	DT	_	69	dep	_	_
68	mutant	mutant	JJ	JJ	_	69	amod	_	_
69	endotoxin	endotoxin	NN	NN	_	65	nmod	_	_
70	to	to	TO	TO	_	71	mark	_	_
71	induce	induce	VB	VB	_	65	acl	_	_
72	tumor	tumor	NN	NN	_	75	compound	_	_
73	necrosis	necrosis	NN	NN	_	75	compound	_	_
74	factor-alpha	factor-alpha	NN	NN	_	75	compound	_	_
75	production	production	NN	NN	_	71	dobj	_	_
76	is	be	VBZ	VBZ	_	81	cop	_	_
77	,	,	,	,	_	81	punct	_	_
78	at	at	IN	IN	_	81	advmod	_	_
79	least	least	JJS	JJS	_	78	mwe	_	_
80	in	in	IN	IN	_	81	case	_	_
81	part	part	NN	NN	_	30	conj	_	_
82	,	,	,	,	_	81	punct	_	_
83	due	due	JJ	JJ	_	86	case	_	_
84	to	to	TO	TO	_	83	mwe	_	_
85	its	its	PRP$	PRP$	_	86	nmod:poss	_	_
86	inability	inability	NN	NN	_	81	nmod	_	_
87	to	to	TO	TO	_	88	mark	_	_
88	activate	activate	VB	VB	_	86	acl	_	_
89	mitogen-activated	mitogen-activated	JJ	JJ	_	91	amod	_	_
90	protein	protein	NN	NN	_	91	compound	_	_
91	kinase	kinase	NN	NN	_	88	dobj	_	_
92	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	allosteric	allosteric	JJ	JJ	_	3	amod	_	_
3	drug	drug	NN	NN	_	9	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	o,o'-bismyristoyl	o,o'-bismyristoyl	NN	NN	_	7	compound	_	_
6	thiamine	thiamine	NN	NN	_	7	compound	_	_
7	disulfide	disulfide	NN	NN	_	3	appos	_	_
8	,	,	,	,	_	3	punct	_	_
9	suppresses	suppress	VBZ	VBZ	_	0	root	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	replication	replication	NN	NN	_	9	dobj	_	_
12	through	through	IN	IN	_	13	case	_	_
13	prevention	prevention	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	translocation	translocation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
20	Tat	tat	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	efficacy	efficacy	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	o	o	NN	NN	_	8	compound	_	_
5	,	,	,	,	_	8	punct	_	_
6	o'-bismyristoyl	o'-bismyristoyl	NN	NN	_	8	dep	_	_
7	thiamine	thiamine	NN	NN	_	8	compound	_	_
8	disulfide	disulfide	NN	NN	_	2	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	BMT	bmt	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	detail	detail	NN	NN	_	13	nmod	_	_
16	against	against	IN	IN	_	19	case	_	_
17	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
18	laboratory	laboratory	JJ	JJ	_	19	amod	_	_
19	isolates	isolate	NNS	NNS	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	HTLV-IIIB	htlv-iiib	NN	NN	_	19	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	JRFL	JRFL	NNP	NNP	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	MN	mn	NN	NN	_	21	conj	_	_
27	)	)	-RRB-	-RRB-	_	21	punct	_	_
28	,	,	,	,	_	19	punct	_	_
29	primary	primary	JJ	JJ	_	30	amod	_	_
30	isolates	isolate	NNS	NNS	_	19	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	KMT	kmt	NN	NN	_	30	dep	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	KMO	kmo	NN	NN	_	32	conj	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	,	,	,	,	_	19	punct	_	_
37	and	and	CC	CC	_	19	cc	_	_
38	simian	simian	JJ	JJ	_	40	amod	_	_
39	immunodeficiency	immunodeficiency	NN	NN	_	40	compound	_	_
40	virus	virus	NN	NN	_	19	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	SIVmac251	sivmac251	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	in	in	FW	FW	_	45	compound	_	_
45	vitro	vitro	FW	FW	_	13	advmod	_	_
46	.	.	.	.	_	13	punct	_	_

1	BMT	bmt	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	replication	replication	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HIV-1	hiv-1	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	laboratory	laboratory	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	primary	primary	JJ	JJ	_	9	conj	_	_
12	isolates	isolate	NNS	NNS	_	2	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	2	advmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	BMT	bmt	NN	NN	_	5	nsubj	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	antiviral	antiviral	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	5	dobj	_	_
8	against	against	IN	IN	_	9	case	_	_
9	SIVmac251	sivmac251	NN	NN	_	7	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Minimizing	minimize	VBG	VBG	_	3	amod	_	_
2	energy	energy	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	BMT	bmt	NN	NN	_	6	compound	_	_
6	structure	structure	NN	NN	_	3	nmod	_	_
7	reveal	reveal	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	25	mark	_	_
9	a	a	DT	DT	_	10	det	_	_
10	trans-disulfide	trans-disulfide	NN	NN	_	25	nsubjpass	_	_
11	of	of	IN	IN	_	17	case	_	_
12	thiamine	thiamine	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	holo	holo	NN	NN	_	15	compound	_	_
15	drug	drug	NN	NN	_	12	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	disulfide	disulfide	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TDS	tds	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	19	punct	_	_
21	protodrug	protodrug	NN	NN	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	allosterically	allosterically	RB	RB	_	25	advmod	_	_
25	transited	transit	VBN	VBN	_	7	ccomp	_	_
26	to	to	TO	TO	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	reactive	reactive	JJ	JJ	_	30	amod	_	_
29	twisted	twisted	JJ	JJ	_	30	amod	_	_
30	disulfide	disulfide	NN	NN	_	25	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	BMT	bmt	NN	NN	_	30	nmod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	allo	allo	NN	NN	_	35	compound	_	_
35	drug	drug	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	by	by	IN	IN	_	41	case	_	_
38	o	o	NN	NN	_	41	compound	_	_
39	,	,	,	,	_	41	punct	_	_
40	o'-bismyristoyl	o'-bismyristoyl	JJ	JJ	_	41	amod	_	_
41	esterification	esterification	NN	NN	_	25	nmod	_	_
42	of	of	IN	IN	_	43	case	_	_
43	TDS	tds	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	7	punct	_	_

1	BMT	bmt	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	translocation	translocation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	transactivator	transactivator	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	TAT	tat	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	17	det	_	_
14	cellular	cellular	JJ	JJ	_	17	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factor-KB	factor-kb	NN	NN	_	8	conj	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	2	punct	_	_
23	resulting	result	VBG	VBG	_	2	advcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	suppression	suppression	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	HIV-1	hiv-1	NN	NN	_	29	compound	_	_
29	replication	replication	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Retinoid	retinoid	NN	NN	_	3	compound	_	_
2	X	x	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	c-cerbA/thyroid	c-cerba/thyroid	NN	NN	_	7	compound	_	_
6	hormone	hormone	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	3	conj	_	_
8	regulate	regulate	VBP	VBP	_	0	root	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	cell	cell	NN	NN	_	8	dobj	_	_
11	growth	growth	NN	NN	_	10	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	differentiation	differentiation	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	8	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	receptors	receptor	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	regulators	regulator	NNS	NNS	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	impact	impact	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	retinoid	retinoid	NN	NN	_	9	compound	_	_
8	X	x	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	RXR	rxr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	retinoic	retinoic	JJ	JJ	_	16	amod	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	9	appos	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	RAR	rar	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	of	of	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	c-erbA/thyroid	c-erba/thyroid	NN	NN	_	29	compound	_	_
25	hormone	hormone	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	T3	t3	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	receptor	receptor	NN	NN	_	9	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	c-erbA/TR	c-erba/tr	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	on	on	IN	IN	_	34	case	_	_
34	growth	growth	NN	NN	_	5	nmod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	differentiation	differentiation	NN	NN	_	34	conj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	erythroid	erythroid	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	34	nmod	_	_
40	using	use	VBG	VBG	_	3	xcomp	_	_
41	an	a	DT	DT	_	45	det	_	_
42	in	in	FW	FW	_	45	amod	_	_
43	vitro	vitro	FW	FW	_	42	dep	_	_
44	culture	culture	NN	NN	_	45	compound	_	_
45	system	system	NN	NN	_	40	dobj	_	_
46	of	of	IN	IN	_	51	case	_	_
47	stem	stem	NN	NN	_	51	compound	_	_
48	cell	cell	NN	NN	_	51	compound	_	_
49	factor-dependent	factor-dependent	JJ	JJ	_	51	amod	_	_
50	erythroid	erythroid	JJ	JJ	_	51	amod	_	_
51	progenitors	progenitor	NNS	NNS	_	45	nmod	_	_
52	.	.	.	.	_	3	punct	_	_

1	RXR	rxr	NN	NN	_	9	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	RAR	rar	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	c-erbA/TR-specific	c-erba/tr-specific	JJ	JJ	_	7	amod	_	_
7	ligands	ligand	NNS	NNS	_	1	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	9	ccomp	_	_
12	erythroid-specific	erythroid-specific	JJ	JJ	_	14	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	accelerate	accelerate	VB	VB	_	11	conj	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	culture	culture	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	with	with	IN	IN	_	27	mark	_	_
24	T3	t3	NN	NN	_	27	nsubj	_	_
25	being	be	VBG	VBG	_	27	cop	_	_
26	most	most	RBS	RBS	_	27	advmod	_	_
27	effective	effective	JJ	JJ	_	17	advcl	_	_
28	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	while	while	IN	IN	_	6	mark	_	_
4	ligand-activated	ligand-activated	JJ	JJ	_	5	amod	_	_
5	c-erbA/TR	c-erba/tr	NN	NN	_	6	nsubj	_	_
6	accelerated	accelerate	VBD	VBD	_	12	advcl	_	_
7	differentiation	differentiation	NN	NN	_	6	dobj	_	_
8	,	,	,	,	_	12	punct	_	_
9	unliganded	unliganded	JJ	JJ	_	10	amod	_	_
10	c-erbA/TR	c-erba/tr	NN	NN	_	12	nsubj	_	_
11	effectively	effectively	RB	RB	_	12	advmod	_	_
12	blocked	block	VBD	VBD	_	0	root	_	_
13	differentiation	differentiation	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	supported	support	VBD	VBD	_	12	conj	_	_
16	sustained	sustained	JJ	JJ	_	18	amod	_	_
17	progenitor	progenitor	NN	NN	_	18	compound	_	_
18	growth	growth	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	culture	culture	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	c-erbA/TR	c-erba/tr	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	act	act	VB	VB	_	4	xcomp	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	binary	binary	JJ	JJ	_	10	amod	_	_
10	switch	switch	NN	NN	_	6	nmod	_	_
11	affecting	affect	VBG	VBG	_	10	acl	_	_
12	erythroid	erythroid	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	fate	fate	NN	NN	_	11	dobj	_	_
15	:	:	:	:	_	4	punct	_	_
16	unliganded	unliganded	JJ	JJ	_	17	amod	_	_
17	c-erbA/TR	c-erba/tr	NN	NN	_	18	nsubj	_	_
18	supports	support	VBZ	VBZ	_	4	parataxis	_	_
19	growth	growth	NN	NN	_	18	dobj	_	_
20	while	while	IN	IN	_	23	mark	_	_
21	ligand-activated	ligand-activated	JJ	JJ	_	22	amod	_	_
22	c-erbA/TR	c-erba/tr	NN	NN	_	23	nsubj	_	_
23	induces	induce	VBZ	VBZ	_	18	advcl	_	_
24	differentiation	differentiation	NN	NN	_	23	dobj	_	_
25	.	.	.	.	_	18	punct	_	_

1	Additionally	additionally	RB	RB	_	39	advmod	_	_
2	,	,	,	,	_	39	punct	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	39	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	impact	impact	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	RXR	rxr	NN	NN	_	6	nmod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	39	punct	_	_
14	dominant	dominant	JJ	JJ	_	15	dep	_	_
15	interfering	interfere	VBG	VBG	_	17	amod	_	_
16	mutant	mutant	JJ	JJ	_	17	amod	_	_
17	RXRs	rxr	NNS	NNS	_	39	nsubjpass	_	_
18	,	,	,	,	_	17	punct	_	_
19	lacking	lack	VBG	VBG	_	17	acl	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
22	activator	activator	NN	NN	_	23	compound	_	_
23	functions	function	NNS	NNS	_	19	dobj	_	_
24	AF-1	af-1	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	AF-2	af-2	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	or	or	CC	CC	_	24	cc	_	_
29	AF-2	af-2	NN	NN	_	24	conj	_	_
30	only	only	RB	RB	_	29	advmod	_	_
31	,	,	,	,	_	23	punct	_	_
32	or	or	CC	CC	_	23	cc	_	_
33	the	the	DT	DT	_	36	det	_	_
34	entire	entire	JJ	JJ	_	36	amod	_	_
35	DNA-binding	dna-binding	JJ	JJ	_	36	amod	_	_
36	domain	domain	NN	NN	_	23	conj	_	_
37	,	,	,	,	_	17	punct	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	introduced	introduce	VBN	VBN	_	0	root	_	_
40	into	into	IN	IN	_	43	case	_	_
41	erythroid	erythroid	JJ	JJ	_	43	amod	_	_
42	progenitor	progenitor	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	nmod	_	_
44	via	via	IN	IN	_	47	case	_	_
45	recombinant	recombinant	JJ	JJ	_	47	amod	_	_
46	retrovirus	retrovirus	NN	NN	_	47	compound	_	_
47	vectors	vector	NNS	NNS	_	43	nmod	_	_
48	and	and	CC	CC	_	39	cc	_	_
49	analyzed	analyze	VBN	VBN	_	39	conj	_	_
50	for	for	IN	IN	_	52	case	_	_
51	RXR-specific	rxr-specific	JJ	JJ	_	52	amod	_	_
52	effects	effect	NNS	NNS	_	49	nmod	_	_
53	.	.	.	.	_	39	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	expression	expression	NN	NN	_	19	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	wild-type	wild-type	JJ	JJ	_	8	amod	_	_
8	RXR	rxr	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	RXR	rxr	NN	NN	_	13	compound	_	_
13	mutants	mutant	NNS	NNS	_	8	conj	_	_
14	devoid	devoid	JJ	JJ	_	13	amod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	AF-1	af-1	NN	NN	_	14	nmod	_	_
17	and/or	and/or	CC	CC	_	16	cc	_	_
18	AF-2	af-2	NN	NN	_	16	conj	_	_
19	supported	support	VBD	VBD	_	3	ccomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	transient	transient	JJ	JJ	_	22	amod	_	_
22	outgrowth	outgrowth	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	erythroid	erythroid	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	marked	marked	JJ	JJ	_	3	amod	_	_
3	contrast	contrast	NN	NN	_	24	nmod	_	_
4	,	,	,	,	_	24	punct	_	_
5	expression	expression	NN	NN	_	24	nsubj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	dominant	dominant	JJ	JJ	_	12	amod	_	_
9	interfering	interfere	VBG	VBG	_	12	amod	_	_
10	deltaDNA-binding	deltadna-binding	JJ	JJ	_	12	amod	_	_
11	domain	domain	NN	NN	_	12	compound	_	_
12	RXR	rxr	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	containing	contain	VBG	VBG	_	12	acl	_	_
15	a	a	DT	DT	_	16	det	_	_
16	deletion	deletion	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	entire	entire	JJ	JJ	_	21	amod	_	_
20	DNA-binding	dna-binding	JJ	JJ	_	21	amod	_	_
21	domain	domain	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	incompatible	incompatible	JJ	JJ	_	0	root	_	_
25	with	with	IN	IN	_	28	case	_	_
26	erythroid	erythroid	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	growth	growth	NN	NN	_	24	nmod	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vitro	vitro	FW	FW	_	24	advmod	_	_
31	,	,	,	,	_	24	punct	_	_
32	suggesting	suggest	VBG	VBG	_	24	xcomp	_	_
33	a	a	DT	DT	_	35	det	_	_
34	pivotal	pivotal	JJ	JJ	_	35	amod	_	_
35	role	role	NN	NN	_	32	dobj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	RXR	rxr	NN	NN	_	35	nmod	_	_
38	for	for	IN	IN	_	41	case	_	_
39	erythroid	erythroid	JJ	JJ	_	41	amod	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	development	development	NN	NN	_	35	nmod	_	_
42	.	.	.	.	_	24	punct	_	_

1	Phosphatidylinositides	phosphatidylinositide	NNS	NNS	_	2	nsubj	_	_
2	bind	bind	VBP	VBP	_	0	root	_	_
3	to	to	TO	TO	_	6	case	_	_
4	plasma	plasma	NN	NN	_	6	compound	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	CD14	cd14	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	prevent	prevent	VB	VB	_	2	conj	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	by	by	IN	IN	_	14	case	_	_
13	bacterial	bacterial	JJ	JJ	_	14	amod	_	_
14	lipopolysaccharide	lipopolysaccharide	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	13	mark	_	_
2	bacterial	bacterial	JJ	JJ	_	3	amod	_	_
3	lipopolysaccharides	lipopolysaccharide	NNS	NNS	_	13	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	LPS	lp	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	several	several	JJ	JJ	_	11	amod	_	_
9	other	other	JJ	JJ	_	11	amod	_	_
10	microbial	microbial	JJ	JJ	_	11	amod	_	_
11	agonists	agonist	NNS	NNS	_	3	conj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	bind	bind	VB	VB	_	36	advcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	mCD14	mcd14	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	membrane	membrane	NN	NN	_	18	compound	_	_
18	CD14	cd14	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	15	punct	_	_
21	a	a	DT	DT	_	23	det	_	_
22	cell-surface	cell-surface	JJ	JJ	_	23	amod	_	_
23	receptor	receptor	NN	NN	_	15	appos	_	_
24	found	find	VBN	VBN	_	23	acl	_	_
25	principally	principally	RB	RB	_	27	advmod	_	_
26	on	on	IN	IN	_	27	case	_	_
27	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	neutrophils	neutrophil	NNS	NNS	_	27	conj	_	_
30	,	,	,	,	_	36	punct	_	_
31	host-derived	host-derived	JJ	JJ	_	33	amod	_	_
32	mCD14	mcd14	NN	NN	_	33	compound	_	_
33	ligands	ligand	NNS	NNS	_	36	nsubjpass	_	_
34	are	be	VBP	VBP	_	36	auxpass	_	_
35	poorly	poorly	RB	RB	_	36	advmod	_	_
36	defined	define	VBN	VBN	_	0	root	_	_
37	.	.	.	.	_	36	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	phosphatidylinositol	phosphatidylinositol	NN	NN	_	16	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PtdIns	ptdins	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	phosphatidylinositol-4-phosphate	phosphatidylinositol-4-phosphate	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	5	punct	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	other	other	JJ	JJ	_	14	amod	_	_
14	phosphatidylinositides	phosphatidylinositide	NNS	NNS	_	5	conj	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	bind	bind	VB	VB	_	2	ccomp	_	_
17	to	to	TO	TO	_	18	case	_	_
18	mCD14	mcd14	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Phosphatidylserine	phosphatidylserine	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	PS	ps	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	another	another	DT	DT	_	8	det	_	_
7	anionic	anionic	JJ	JJ	_	8	amod	_	_
8	glycerophospholipid	glycerophospholipid	NN	NN	_	1	appos	_	_
9	,	,	,	,	_	1	punct	_	_
10	binds	bind	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	mCD14	mcd14	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	lower	lower	JJR	JJR	_	16	amod	_	_
15	apparent	apparent	JJ	JJ	_	16	amod	_	_
16	affinity	affinity	NN	NN	_	10	nmod	_	_
17	than	than	IN	IN	_	18	dep	_	_
18	does	do	VBZ	VBZ	_	16	dep	_	_
19	PtdIns	ptdins	NN	NN	_	18	nsubj	_	_
20	.	.	.	.	_	10	punct	_	_

1	LPS-binding	lps-binding	JJ	JJ	_	2	amod	_	_
2	protein	protein	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	lipid	lipid	NN	NN	_	7	compound	_	_
6	transfer	transfer	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	appos	_	_
8	found	find	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	serum	serum	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	facilitates	facilitate	VBZ	VBZ	_	0	root	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	PS-	ps-	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	PtdIns-mCD14	ptdins-mcd14	NN	NN	_	14	conj	_	_
17	binding	binding	NN	NN	_	12	dobj	_	_
18	.	.	.	.	_	12	punct	_	_

1	PtdIns	ptdins	NN	NN	_	7	nsubjpass	_	_
2	binding	bind	VBG	VBG	_	1	acl	_	_
3	to	to	TO	TO	_	4	case	_	_
4	mCD14	mcd14	NN	NN	_	2	nmod	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	anti-CD14	anti-cd14	JJ	JJ	_	11	amod	_	_
10	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
11	antibodies	antibody	NNS	NNS	_	7	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	inhibit	inhibit	VBP	VBP	_	11	acl:relcl	_	_
14	LPS-mCD14	lps-mcd14	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	7	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	PtdIns	ptdins	NN	NN	_	20	nsubj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	inhibit	inhibit	VB	VB	_	7	conj	_	_
21	both	both	CC	CC	_	23	cc:preconj	_	_
22	LPS-mCD14	lps-mcd14	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	LPS-induced	lps-induced	JJ	JJ	_	26	amod	_	_
26	responses	response	NNS	NNS	_	23	conj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Serum-equilibrated	serum-equilibrated	JJ	JJ	_	2	amod	_	_
2	PtdIns	ptdins	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	mCD14-expressing	mcd14-expressing	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	raising	raise	VBG	VBG	_	4	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	possibility	possibility	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	endogenous	endogenous	JJ	JJ	_	14	amod	_	_
14	PtdIns	ptdins	NN	NN	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	modulate	modulate	VB	VB	_	11	ccomp	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	responses	response	NNS	NNS	_	16	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	LPS	lp	NNS	NNS	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	other	other	JJ	JJ	_	24	amod	_	_
23	mCD14	mcd14	NN	NN	_	24	compound	_	_
24	ligands	ligand	NNS	NNS	_	20	conj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	16	advmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	Rta	rta	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	0	root	_	_
7	lytic	lytic	JJ	JJ	_	9	amod	_	_
8	cycle	cycle	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	6	dobj	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	disrupt	disrupt	VB	VB	_	6	conj	_	_
13	latency	latency	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	transition	transition	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
5	virus	virus	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EBV	ebv	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	from	from	IN	IN	_	10	case	_	_
10	latency	latency	NN	NN	_	2	nmod	_	_
11	into	into	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	lytic	lytic	JJ	JJ	_	14	amod	_	_
14	cycle	cycle	NN	NN	_	2	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	two	two	CD	CD	_	24	nummod	_	_
22	immediate-early	immediate-early	JJ	JJ	_	24	amod	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	19	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	BZLF1	bzlf1	NN	NN	_	24	appos	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	BRLF1	brlf1	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	16	punct	_	_

1	Overexpression	overexpression	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ZEBRA	zebra	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	product	product	NN	NN	_	3	appos	_	_
7	of	of	IN	IN	_	8	case	_	_
8	BZLF1	bzlf1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	disrupt	disrupt	VB	VB	_	11	xcomp	_	_
14	latency	latency	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	epithelial	epithelial	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	stimulating	stimulate	VBG	VBG	_	13	advcl	_	_
23	expression	expression	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	lytic	lytic	JJ	JJ	_	27	amod	_	_
26	cycle	cycle	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	including	include	VBG	VBG	_	30	case	_	_
30	BRLF1	brlf1	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	BRLF1	brlf1	NN	NN	_	4	compound	_	_
3	product	product	NN	NN	_	4	compound	_	_
4	Rta	rta	NN	NN	_	5	nsubj	_	_
5	functions	function	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activator	activator	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	epithelial	epithelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	Rta	rta	NN	NN	_	7	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	7	aux	_	_
5	recently	recently	RB	RB	_	7	advmod	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	reported	report	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	disrupt	disrupt	VB	VB	_	7	xcomp	_	_
10	latency	latency	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	an	a	DT	DT	_	15	det	_	_
13	epithelial	epithelial	JJ	JJ	_	15	amod	_	_
14	specific	specific	JJ	JJ	_	15	amod	_	_
15	manner	manner	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	S.	S.	NNP	NNP	_	18	compound	_	_
18	Zalani	Zalani	NNP	NNP	_	7	dep	_	_
19	,	,	,	,	_	18	punct	_	_
20	E.	E.	NNP	NNP	_	21	compound	_	_
21	Holley-Guthrie	Holley-Guthrie	NNP	NNP	_	18	conj	_	_
22	,	,	,	,	_	18	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	S.	S.	NNP	NNP	_	25	compound	_	_
25	Kenney	Kenney	NNP	NNP	_	18	conj	_	_
26	,	,	,	,	_	18	punct	_	_
27	Proc.	Proc.	NNP	NNP	_	31	compound	_	_
28	Natl.	Natl.	NNP	NNP	_	31	compound	_	_
29	Acad.	Acad.	NNP	NNP	_	31	compound	_	_
30	Sci.	Sci.	NNP	NNP	_	31	compound	_	_
31	USA	USA	NNP	NNP	_	18	appos	_	_
32	93	93	CD	CD	_	31	nummod	_	_
33	:	:	:	:	_	31	punct	_	_
34	9194-9199	9194-9199	CD	CD	_	31	dep	_	_
35	,	,	,	,	_	18	punct	_	_
36	1996	1996	CD	CD	_	18	amod	_	_
37	)	)	-RRB-	-RRB-	_	18	punct	_	_
38	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Rta	rta	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
11	for	for	IN	IN	_	12	case	_	_
12	disruption	disruption	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	latency	latency	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	permissive	permissive	JJ	JJ	_	19	amod	_	_
18	B-cell	b-cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	HH514-16	hh514-16	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	transfection	transfection	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Rta	rta	NN	NN	_	5	nmod	_	_
8	leads	lead	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	synthesis	synthesis	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ZEBRA	zebra	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	viral	viral	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	10	conj	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	late	late	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	10	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	Rta	rta	NN	NN	_	8	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	itself	itself	PRP	PRP	_	8	nmod	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	less	less	RBR	RBR	_	8	advmod	_	_
8	potent	potent	JJ	JJ	_	0	root	_	_
9	than	than	IN	IN	_	10	case	_	_
10	ZEBRA	zebra	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	8	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	activate	activate	VB	VB	_	13	acl	_	_
16	most	most	RBS	RBS	_	22	advmod	_	_
17	early	early	JJ	JJ	_	22	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	late	late	JJ	JJ	_	17	conj	_	_
20	lytic	lytic	JJ	JJ	_	22	amod	_	_
21	cycle	cycle	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	15	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	light	light	NN	NN	_	5	dep	_	_
3	of	of	IN	IN	_	5	case	_	_
4	previous	previous	JJ	JJ	_	5	amod	_	_
5	work	work	NN	NN	_	15	nmod	_	_
6	implicating	implicate	VBG	VBG	_	5	acl	_	_
7	ZEBRA	zebra	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Rta	rta	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	suggest	suggest	VBP	VBP	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	cooperative	cooperative	JJ	JJ	_	18	amod	_	_
18	model	model	NN	NN	_	15	dobj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	EBV	ebv	NN	NN	_	21	compound	_	_
21	entry	entry	NN	NN	_	18	nmod	_	_
22	into	into	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	lytic	lytic	JJ	JJ	_	25	amod	_	_
25	cycle	cycle	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Expression	expression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	either	either	CC	CC	_	4	cc:preconj	_	_
4	BZLF1	bzlf1	NN	NN	_	1	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	BRLF1	brlf1	NN	NN	_	4	conj	_	_
7	triggers	trigger	VBZ	VBZ	_	0	root	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	immediate-early	immediate-early	JJ	JJ	_	13	amod	_	_
13	factor	factor	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	together	together	RB	RB	_	19	advmod	_	_
17	these	these	DT	DT	_	18	det	_	_
18	activators	activator	NNS	NNS	_	19	nsubj	_	_
19	act	act	VBP	VBP	_	7	conj	_	_
20	individually	individually	RB	RB	_	21	advmod	_	_
21	or	or	CC	CC	_	19	advmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	synergy	synergy	NN	NN	_	21	conj	_	_
24	on	on	IN	IN	_	26	case	_	_
25	downstream	downstream	JJ	JJ	_	26	amod	_	_
26	targets	target	NNS	NNS	_	23	nmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	activate	activate	VB	VB	_	19	xcomp	_	_
29	the	the	DT	DT	_	32	det	_	_
30	viral	viral	JJ	JJ	_	32	amod	_	_
31	lytic	lytic	JJ	JJ	_	32	amod	_	_
32	cycle	cycle	NN	NN	_	28	dobj	_	_
33	.	.	.	.	_	7	punct	_	_

1	Molecular	molecular	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cellular	cellular	JJ	JJ	_	1	conj	_	_
4	analysis	analysis	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	8	nmod:npmod	_	_
8	virus-induced	virus-induced	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	17	case	_	_
11	lymphoblastoid	lymphoblastoid	JJ	JJ	_	17	amod	_	_
12	T-cell-line-expressing	t-cell-line-expressing	JJ	JJ	_	17	amod	_	_
13	wild-type	wild-type	JJ	JJ	_	17	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	mutated	mutate	VBN	VBN	_	13	conj	_	_
16	CD4	cd4	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	4	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	presence	presence	NN	NN	_	14	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	CD4	cd4	NN	NN	_	12	compound	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
12	tail	tail	NN	NN	_	7	nmod	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	critical	critical	JJ	JJ	_	4	ccomp	_	_
15	for	for	IN	IN	_	23	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
18	virus	virus	NN	NN	_	22	nmod:npmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HIV	hiv	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	-induced	-induced	JJ	JJ	_	23	amod	_	_
23	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	J.Corbeil	J.Corbeil	NNP	NNP	_	14	dep	_	_
26	,	,	,	,	_	25	punct	_	_
27	M.Tremblay	M.Tremblay	NNP	NNP	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	D.D.Richman	D.D.Richman	NNP	NNP	_	25	conj	_	_
31	,	,	,	,	_	25	punct	_	_
32	J.Exp.Med.183	J.Exp.Med.183	NNP	NNP	_	25	appos	_	_
33	:	:	:	:	_	32	punct	_	_
34	39-48	39-48	CD	CD	_	32	nummod	_	_
35	,	,	,	,	_	25	punct	_	_
36	1996	1996	CD	CD	_	25	amod	_	_
37	)	)	-RRB-	-RRB-	_	25	punct	_	_
38	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	pursued	pursue	VBN	VBN	_	0	root	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	investigation	investigation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	CD4	cd4	NN	NN	_	13	compound	_	_
12	transduction	transduction	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	HIV-induced	hiv-induced	JJ	JJ	_	16	amod	_	_
16	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	do	do	VBP	VBP	_	16	advcl	_	_
3	this	this	DT	DT	_	2	dobj	_	_
4	,	,	,	,	_	16	punct	_	_
5	wild-type	wild-type	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	mutant	mutant	JJ	JJ	_	5	conj	_	_
8	forms	form	NNS	NNS	_	16	nsubjpass	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	CD4	cd4	NN	NN	_	13	compound	_	_
12	cytoplasmic	cytoplasmic	JJ	JJ	_	13	amod	_	_
13	tail	tail	NN	NN	_	8	nmod	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	stably	stably	RB	RB	_	16	advmod	_	_
16	expressed	express	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	lymphoblastoid	lymphoblastoid	JJ	JJ	_	22	amod	_	_
20	T-cell	t-cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	A2.01	a2.01	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	prevented	prevent	VBN	VBN	_	0	root	_	_
4	when	when	WRB	WRB	_	11	advmod	_	_
5	CD4	cd4	NN	NN	_	11	nsubjpass	_	_
6	truncated	truncate	VBN	VBN	_	5	acl	_	_
7	at	at	IN	IN	_	8	case	_	_
8	residue	residue	NN	NN	_	6	nmod	_	_
9	402	402	CD	CD	_	8	nummod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	3	advcl	_	_
12	;	;	:	:	_	3	punct	_	_
13	however	however	RB	RB	_	46	advmod	_	_
14	,	,	,	,	_	46	punct	_	_
15	cells	cell	NNS	NNS	_	46	nsubj	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	mutated	mutate	VBN	VBN	_	18	amod	_	_
18	receptors	receptor	NNS	NNS	_	16	dobj	_	_
19	that	that	WDT	WDT	_	22	nsubj	_	_
20	do	do	VBP	VBP	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	associate	associate	VB	VB	_	18	acl:relcl	_	_
23	with	with	IN	IN	_	24	case	_	_
24	p56(lck)	p56(lck)	NN	NN	_	22	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	mutated	mutate	VBN	VBN	_	24	dep	_	_
27	at	at	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	dicysteine	dicysteine	NN	NN	_	30	compound	_	_
30	motif	motif	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	truncated	truncate	VBN	VBN	_	26	conj	_	_
33	at	at	IN	IN	_	34	case	_	_
34	residue	residue	NN	NN	_	32	nmod	_	_
35	418	418	CD	CD	_	34	nummod	_	_
36	)	)	-RRB-	-RRB-	_	26	punct	_	_
37	but	but	CC	CC	_	22	cc	_	_
38	which	which	WDT	WDT	_	39	nsubj	_	_
39	conserved	conserve	VBD	VBD	_	22	conj	_	_
40	proximal	proximal	JJ	JJ	_	41	amod	_	_
41	domains	domain	NNS	NNS	_	39	dobj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	cytoplasmic	cytoplasmic	JJ	JJ	_	45	amod	_	_
45	tail	tail	NN	NN	_	41	nmod	_	_
46	underwent	undergo	VBD	VBD	_	3	parataxis	_	_
47	apoptosis	apoptosis	NN	NN	_	46	dobj	_	_
48	like	like	IN	IN	_	50	case	_	_
49	wild-type	wild-type	JJ	JJ	_	50	amod	_	_
50	CD4	cd4	NN	NN	_	46	nmod	_	_
51	.	.	.	.	_	46	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	15	nsubj	_	_
3	between	between	IN	IN	_	7	case	_	_
4	wild-type	wild-type	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	mutated	mutate	VBN	VBN	_	4	conj	_	_
7	receptors	receptor	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	apoptosis	apoptosis	NN	NN	_	10	nmod	_	_
13	were	be	VBD	VBD	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	related	related	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	levels	level	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	p56(lck)	p56(lck)	NN	NN	_	22	compound	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	19	conj	_	_
22	activation	activation	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Initial	initial	JJ	JJ	_	2	amod	_	_
2	signaling	signaling	NN	NN	_	7	nsubj	_	_
3	through	through	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD4	cd4	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	nmod	_	_
7	played	play	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	major	major	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	sensitization	sensitization	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	HIV-infected	hiv-infected	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	undergo	undergo	VB	VB	_	7	advcl	_	_
20	apoptosis	apoptosis	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	Incubation	incubation	NN	NN	_	27	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HIV-infected	hiv-infected	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	11	case	_	_
6	monoclonal	monoclonal	JJ	JJ	_	11	amod	_	_
7	antibody	antibody	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	MAb	mab	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	13B8-2	13b8-2	NN	NN	_	1	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	11	acl:relcl	_	_
15	to	to	TO	TO	_	16	case	_	_
16	CD4	cd4	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	region	region	NN	NN	_	14	nmod	_	_
20	critical	critical	JJ	JJ	_	19	amod	_	_
21	for	for	IN	IN	_	22	case	_	_
22	dimerization	dimerization	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	receptor	receptor	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	11	punct	_	_
27	prevented	prevent	VBD	VBD	_	0	root	_	_
28	apoptosis	apoptosis	NN	NN	_	27	dobj	_	_
29	without	without	IN	IN	_	30	mark	_	_
30	inhibiting	inhibit	VBG	VBG	_	27	advcl	_	_
31	HIV	hiv	NN	NN	_	32	compound	_	_
32	replication	replication	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	27	punct	_	_

1	Moreover	moreover	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	apoptotic	apoptotic	JJ	JJ	_	5	amod	_	_
5	process	process	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	related	related	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	Fas-Fas	fas-fas	JJ	JJ	_	12	amod	_	_
11	ligand	ligand	NN	NN	_	12	compound	_	_
12	interaction	interaction	NN	NN	_	8	nmod	_	_
13	;	;	:	:	_	8	punct	_	_
14	however	however	RB	RB	_	23	advmod	_	_
15	,	,	,	,	_	23	punct	_	_
16	an	a	DT	DT	_	19	det	_	_
17	antagonistic	antagonistic	JJ	JJ	_	19	amod	_	_
18	anti-Fas	anti-fas	JJ	JJ	_	19	amod	_	_
19	MAb	mab	NN	NN	_	23	nsubj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ZB-4	zb-4	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	enhanced	enhance	VBD	VBD	_	8	parataxis	_	_
24	apoptosis	apoptosis	NN	NN	_	23	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	HIV-infected	hiv-infected	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	without	without	IN	IN	_	29	mark	_	_
29	inducing	induce	VBG	VBG	_	23	advcl	_	_
30	apoptosis	apoptosis	NN	NN	_	29	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	uninfected	uninfected	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	23	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CD4	cd4	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	7	nsubj	_	_
7	mediates	mediate	VBZ	VBZ	_	3	ccomp	_	_
8	HIV-induced	hiv-induced	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	mechanism	mechanism	NN	NN	_	7	nmod	_	_
13	independent	independent	JJ	JJ	_	12	amod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	Fas-Fas	fas-fas	JJ	JJ	_	17	amod	_	_
16	ligand	ligand	NN	NN	_	17	compound	_	_
17	interaction	interaction	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	does	do	VBZ	VBZ	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	require	require	VB	VB	_	7	conj	_	_
22	p56(lck)	p56(lck)	NN	NN	_	23	compound	_	_
23	signaling	signaling	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	7	punct	_	_
25	and	and	CC	CC	_	7	cc	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	involve	involve	VB	VB	_	7	conj	_	_
28	a	a	DT	DT	_	30	det	_	_
29	critical	critical	JJ	JJ	_	30	amod	_	_
30	region	region	NN	NN	_	27	dobj	_	_
31	for	for	IN	IN	_	33	case	_	_
32	CD4	cd4	NN	NN	_	33	compound	_	_
33	dimerization	dimerization	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Establishment	establishment	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	characterization	characterization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	12	case	_	_
5	EBV-positive	ebv-positive	JJ	JJ	_	12	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	EBV-negative	ebv-negative	JJ	JJ	_	5	conj	_	_
8	primary	primary	JJ	JJ	_	12	amod	_	_
9	effusion	effusion	NN	NN	_	12	compound	_	_
10	lymphoma	lymphoma	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	1	nmod	_	_
13	harbouring	harbour	VBG	VBG	_	12	acl	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	herpesvirus	herpesvirus	NN	NN	_	16	compound	_	_
16	type-8	type-8	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	report	report	VBP	VBP	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	establishment	establishment	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	characterization	characterization	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	two	two	CD	CD	_	16	nummod	_	_
13	novel	novel	JJ	JJ	_	16	amod	_	_
14	lymphoma	lymphoma	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	8	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CRO-AP/3	cro-ap/3	NN	NN	_	16	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CRO-AP/5	cro-ap/5	NN	NN	_	18	conj	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	carry	carry	VBP	VBP	_	16	acl:relcl	_	_
24	infection	infection	NN	NN	_	23	dobj	_	_
25	by	by	IN	IN	_	28	case	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	herpesvirus	herpesvirus	NN	NN	_	28	compound	_	_
28	type-8	type-8	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HHV-8	hhv-8	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	23	cc	_	_
33	have	have	VBP	VBP	_	34	aux	_	_
34	derived	derive	VBN	VBN	_	23	conj	_	_
35	from	from	IN	IN	_	39	case	_	_
36	AIDS-related	aids-related	JJ	JJ	_	39	amod	_	_
37	primary	primary	JJ	JJ	_	39	amod	_	_
38	effusion	effusion	NN	NN	_	39	compound	_	_
39	lymphoma	lymphoma	NN	NN	_	34	nmod	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	PEL	pel	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	two	two	CD	CD	_	4	nummod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	representative	representative	JJ	JJ	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	different	different	JJ	JJ	_	10	amod	_	_
9	virologic	virologic	JJ	JJ	_	10	amod	_	_
10	subtypes	subtype	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	PEL	pel	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	i.e.	i.e.	FW	FW	_	16	dep	_	_
15	HHV-8+/EBV-	hhv-8+/ebv-	JJ	JJ	_	16	amod	_	_
16	PEL	pel	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	case	case	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CRO-AP/3	cro-ap/3	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	HHV-8+/EBV+	hhv-8+/ebv+	JJ	JJ	_	24	amod	_	_
24	PEL	pel	NN	NN	_	16	conj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	case	case	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	CRO-AP/5	cro-ap/5	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	Consistent	consistent	JJ	JJ	_	12	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	diagnosis	diagnosis	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PEL	pel	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	CRO-AP/3	cro-ap/3	NN	NN	_	12	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	CRO-AP/5	cro-ap/5	NN	NN	_	9	conj	_	_
12	expressed	express	VBD	VBD	_	0	root	_	_
13	indeterminate	indeterminate	JJ	JJ	_	20	amod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	i.e.	i.e.	FW	FW	_	16	dep	_	_
16	non-B	non-b	JJ	JJ	_	20	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	non-T	non-t	JJ	JJ	_	16	dep	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	phenotypes	phenotype	NNS	NNS	_	12	dobj	_	_
21	although	although	IN	IN	_	24	mark	_	_
22	immunogenotypic	immunogenotypic	JJ	JJ	_	23	amod	_	_
23	studies	study	NNS	NNS	_	24	nsubj	_	_
24	documented	document	VBD	VBD	_	12	advcl	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	B-cell	b-cell	NN	NN	_	27	compound	_	_
27	origin	origin	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	12	punct	_	_

1	Both	both	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	devoid	devoid	JJ	JJ	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	genetic	genetic	JJ	JJ	_	8	amod	_	_
8	lesions	lesion	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-MYC	c-myc	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	BCL-2	bcl-2	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	p53	p53	NN	NN	_	10	conj	_	_
15	as	as	RB	RB	_	8	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	gross	gross	JJ	JJ	_	19	amod	_	_
19	rearrangements	rearrangement	NNS	NNS	_	8	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	BCL-6	bcl-6	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Detailed	detailed	JJ	JJ	_	3	amod	_	_
2	histogenetic	histogenetic	JJ	JJ	_	3	amod	_	_
3	characterization	characterization	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	these	these	DT	DT	_	9	det	_	_
6	novel	novel	JJ	JJ	_	9	amod	_	_
7	PEL	pel	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	3	nmod	_	_
10	suggests	suggest	VBZ	VBZ	_	0	root	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	PEL	pel	NN	NN	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	derive	derive	VB	VB	_	10	ccomp	_	_
15	from	from	IN	IN	_	20	case	_	_
16	a	a	DT	DT	_	20	det	_	_
17	post-germinal	post-germinal	JJ	JJ	_	20	amod	_	_
18	centre	centre	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cell	cell	NN	NN	_	14	nmod	_	_
21	which	which	WDT	WDT	_	23	nsubj	_	_
22	has	have	VBZ	VBZ	_	23	aux	_	_
23	undergone	undergo	VBN	VBN	_	20	acl:relcl	_	_
24	pre-terminal	pre-terminal	JJ	JJ	_	25	amod	_	_
25	differentiation	differentiation	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	CRO-AP/3	cro-ap/3	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CRO-AP/5	cro-ap/5	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	2	conj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	provide	provide	VB	VB	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	valuable	valuable	JJ	JJ	_	11	amod	_	_
11	model	model	NN	NN	_	8	dobj	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	clarifying	clarify	VBG	VBG	_	8	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	pathogenesis	pathogenesis	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	PEL	pel	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	8	advcl	_	_
3	,	,	,	,	_	8	punct	_	_
4	these	these	DT	DT	_	6	det	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	help	help	VB	VB	_	0	root	_	_
9	understand	understand	VB	VB	_	8	ccomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	relative	relative	JJ	JJ	_	12	amod	_	_
12	contribution	contribution	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HHV-8	hhv-8	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	EBV	ebv	NN	NN	_	14	conj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	PEL	pel	NN	NN	_	12	nmod	_	_
19	growth	growth	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	development	development	NN	NN	_	19	conj	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	facilitate	facilitate	VB	VB	_	8	conj	_	_
25	the	the	DT	DT	_	26	det	_	_
26	identification	identification	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	recurrent	recurrent	JJ	JJ	_	30	amod	_	_
29	cytogenetic	cytogenetic	JJ	JJ	_	30	amod	_	_
30	abnormalities	abnormality	NNS	NNS	_	26	nmod	_	_
31	highlighting	highlight	VBG	VBG	_	30	acl	_	_
32	putative	putative	JJ	JJ	_	34	amod	_	_
33	novel	novel	JJ	JJ	_	34	amod	_	_
34	cancer	cancer	NN	NN	_	35	nmod:npmod	_	_
35	related	related	JJ	JJ	_	36	amod	_	_
36	loci	locus	NNS	NNS	_	31	dobj	_	_
37	relevant	relevant	JJ	JJ	_	36	amod	_	_
38	to	to	TO	TO	_	39	case	_	_
39	PEL	pel	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	Interferon-gamma-induced	interferon-gamma-induced	JJ	JJ	_	2	amod	_	_
2	factor	factor	NN	NN	_	0	root	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	interleukin-4-responsive	interleukin-4-responsive	JJ	JJ	_	7	amod	_	_
7	element	element	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CD23b	cd23b	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	tonsillar	tonsillar	JJ	JJ	_	15	amod	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	:	:	:	:	_	2	punct	_	_
17	role	role	NN	NN	_	2	dep	_	_
18	in	in	IN	IN	_	20	case	_	_
19	transient	transient	JJ	JJ	_	20	amod	_	_
20	up-regulation	up-regulation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	interleukin-4-induced	interleukin-4-induced	JJ	JJ	_	25	amod	_	_
24	CD23b	cd23b	NN	NN	_	25	compound	_	_
25	mRNA	mrna	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	tonsillar	tonsillar	JJ	JJ	_	6	amod	_	_
5	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	interleukin-4	interleukin-4	NN	NN	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-4	il-4	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	interferon-gamma	interferon-gamma	NN	NN	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	rapidly	rapidly	RB	RB	_	18	advmod	_	_
18	induced	induce	VBD	VBD	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activation	activation	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	distinct	distinct	JJ	JJ	_	24	amod	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	factors	factor	NNS	NNS	_	20	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	different	different	JJ	JJ	_	27	amod	_	_
27	mobilities	mobility	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	both	both	DT	DT	_	32	nsubj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	which	which	WDT	WDT	_	29	nmod	_	_
32	bind	bind	VBP	VBP	_	24	acl:relcl	_	_
33	the	the	DT	DT	_	36	det	_	_
34	IL-4	il-4	NN	NN	_	36	compound	_	_
35	response	response	NN	NN	_	36	compound	_	_
36	element	element	NN	NN	_	32	dobj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	IL-4RE	il-4re	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	of	of	IN	IN	_	42	case	_	_
41	CD23b	cd23b	NN	NN	_	42	compound	_	_
42	promoter	promoter	NN	NN	_	36	nmod	_	_
43	as	as	IN	IN	_	44	mark	_	_
44	examined	examine	VBN	VBN	_	32	advcl	_	_
45	by	by	IN	IN	_	49	case	_	_
46	electrophoretic	electrophoretic	JJ	JJ	_	49	amod	_	_
47	mobility	mobility	NN	NN	_	49	compound	_	_
48	shift	shift	NN	NN	_	49	compound	_	_
49	assays	assay	NNS	NNS	_	44	nmod	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	EMSA	emsa	NNS	NNS	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	18	punct	_	_

1	Co-treatment	co-treatment	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-4	il-4	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IFN-gamma	ifn-gamma	NN	NN	_	3	conj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	in	in	IN	IN	_	14	case	_	_
9	addition	addition	NN	NN	_	14	dep	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	two	two	CD	CD	_	14	nummod	_	_
13	distinct	distinct	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	6	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	new	new	JJ	JJ	_	18	amod	_	_
18	complex	complex	NN	NN	_	6	dobj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	intermediate	intermediate	JJ	JJ	_	22	amod	_	_
22	mobility	mobility	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-4-induced	il-4-induced	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	reacted	react	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	anti-STAT	anti-stat	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	signal	signal	NN	NN	_	9	compound	_	_
9	transducers	transducer	NNS	NNS	_	6	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activators	activator	NNS	NNS	_	9	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	transcription	transcription	NN	NN	_	11	nmod	_	_
14	)	)	-RRB-	-RRB-	_	9	punct	_	_
15	6	6	CD	CD	_	6	nummod	_	_
16	,	,	,	,	_	4	punct	_	_
17	resulting	result	VBG	VBG	_	4	xcomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	supershift	supershift	NN	NN	_	17	nmod	_	_
21	whereas	whereas	IN	IN	_	4	dep	_	_
22	the	the	DT	DT	_	23	det	_	_
23	formation	formation	NN	NN	_	29	nsubjpass	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	27	amod	_	_
27	complex	complex	NN	NN	_	23	nmod	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	inhibited	inhibit	VBN	VBN	_	4	parataxis	_	_
30	by	by	IN	IN	_	31	case	_	_
31	anti-STAT	anti-stat	NN	NN	_	29	nmod	_	_
32	1	1	CD	CD	_	31	nummod	_	_
33	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	intermediate	intermediate	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	4	nsubj	_	_
4	appeared	appear	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	react	react	VB	VB	_	4	xcomp	_	_
7	with	with	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	anti-STAT	anti-stat	NN	NN	_	6	nmod	_	_
10	6	6	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	anti-STAT	anti-stat	NN	NN	_	9	conj	_	_
13	1	1	CD	CD	_	12	nummod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	IFN-gamma	ifn-gamma	NN	NN	_	6	nsubj	_	_
3	alone	alone	RB	RB	_	2	advmod	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	induce	induce	VB	VB	_	14	advcl	_	_
7	CD23	cd23	NN	NN	_	9	compound	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	14	punct	_	_
11	Northern	northern	NN	NN	_	13	compound	_	_
12	blot	blot	NN	NN	_	13	compound	_	_
13	analysis	analysis	NN	NN	_	14	nsubj	_	_
14	revealed	reveal	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	17	det	_	_
16	transient	transient	JJ	JJ	_	17	amod	_	_
17	up-regulation	up-regulation	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	IL-4-induced	il-4-induced	JJ	JJ	_	22	amod	_	_
21	CD23	cd23	NN	NN	_	22	compound	_	_
22	mRNA	mrna	NN	NN	_	17	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	IFN-gamma	ifn-gamma	NN	NN	_	17	nmod	_	_
25	within	within	IN	IN	_	27	case	_	_
26	2	2	CD	CD	_	27	nummod	_	_
27	h	h	NN	NN	_	17	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	IFN-gamma	ifn-gamma	NN	NN	_	30	compound	_	_
30	treatment	treatment	NN	NN	_	27	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	these	these	DT	DT	_	34	det	_	_
33	tonsillar	tonsillar	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	IL-4RE	il-4re	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IL-4-inducible	il-4-inducible	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	accommodate	accommodate	VB	VB	_	3	ccomp	_	_
13	both	both	CC	CC	_	17	dep	_	_
14	IL-4-	il-4-	NN	NN	_	17	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	14	conj	_	_
17	factors	factor	NNS	NNS	_	12	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	such	such	JJ	JJ	_	21	case	_	_
20	as	as	IN	IN	_	19	mwe	_	_
21	STAT	stat	NNS	NNS	_	17	nmod	_	_
22	6	6	CD	CD	_	21	nummod	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	STAT	stat	NN	NN	_	21	conj	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	,	,	,	,	_	17	punct	_	_
27	either	either	CC	CC	_	32	dep	_	_
28	in	in	IN	IN	_	32	case	_	_
29	homodimeric	homodimeric	JJ	JJ	_	32	amod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	heterodimeric	heterodimeric	JJ	JJ	_	29	conj	_	_
32	forms	form	NNS	NNS	_	17	nmod	_	_
33	and	and	CC	CC	_	12	cc	_	_
34	the	the	DT	DT	_	35	det	_	_
35	binding	binding	NN	NN	_	45	nsubj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	these	these	DT	DT	_	39	det	_	_
38	different	different	JJ	JJ	_	39	amod	_	_
39	proteins	protein	NNS	NNS	_	35	nmod	_	_
40	to	to	TO	TO	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	respective	respective	JJ	JJ	_	43	amod	_	_
43	promoter	promoter	NN	NN	_	35	nmod	_	_
44	may	may	MD	MD	_	45	aux	_	_
45	play	play	VB	VB	_	12	conj	_	_
46	a	a	DT	DT	_	49	det	_	_
47	potential	potential	JJ	JJ	_	49	amod	_	_
48	regulatory	regulatory	JJ	JJ	_	49	amod	_	_
49	role	role	NN	NN	_	45	dobj	_	_
50	in	in	IN	IN	_	54	case	_	_
51	the	the	DT	DT	_	54	det	_	_
52	IL-4-inducible	il-4-inducible	JJ	JJ	_	54	amod	_	_
53	gene	gene	NN	NN	_	54	compound	_	_
54	expression	expression	NN	NN	_	45	nmod	_	_
55	.	.	.	.	_	3	punct	_	_

1	Models	model	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	lineage	lineage	NN	NN	_	4	compound	_	_
4	switching	switching	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
7	development	development	NN	NN	_	1	nmod	_	_
8	:	:	:	:	_	1	punct	_	_
9	a	a	DT	DT	_	14	det	_	_
10	new	new	JJ	JJ	_	14	amod	_	_
11	myeloid-committed	myeloid-committed	JJ	JJ	_	14	amod	_	_
12	eosinophil	eosinophil	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	18	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	YJ	yj	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	demonstrates	demonstrate	VBZ	VBZ	_	1	dep	_	_
19	trilineage	trilineage	NN	NN	_	20	compound	_	_
20	potential	potential	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	new	new	JJ	JJ	_	6	amod	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	leukemia	leukemia	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	16	nsubjpass	_	_
7	with	with	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	eosinophilic	eosinophilic	JJ	JJ	_	10	amod	_	_
10	phenotype	phenotype	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	designated	designate	VBN	VBN	_	6	acl	_	_
13	YJ	yj	NN	NN	_	12	xcomp	_	_
14	,	,	,	,	_	6	punct	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	established	establish	VBN	VBN	_	0	root	_	_
17	from	from	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	patient	patient	NN	NN	_	21	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	chronic	chronic	JJ	JJ	_	28	amod	_	_
27	myelomonocytic	myelomonocytic	JJ	JJ	_	28	amod	_	_
28	leukemia	leukemia	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CMMoL	cmmol	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	with	with	IN	IN	_	33	case	_	_
33	eosinophilia	eosinophilia	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	cultured	culture	VBN	VBN	_	18	advcl	_	_
3	in	in	IN	IN	_	6	case	_	_
4	RPMI	rpmi	NN	NN	_	6	compound	_	_
5	1640	1640	CD	CD	_	6	nummod	_	_
6	medium	medium	NN	NN	_	2	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	10	10	CD	CD	_	9	compound	_	_
9	%	%	NN	NN	_	12	amod	_	_
10	fetal	fetal	JJ	JJ	_	12	amod	_	_
11	bovine	bovine	JJ	JJ	_	12	amod	_	_
12	serum	serum	NN	NN	_	7	dobj	_	_
13	,	,	,	,	_	18	punct	_	_
14	most	most	JJS	JJS	_	16	amod	_	_
15	YJ	yj	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	myeloblastoid	myeloblastoid	JJ	JJ	_	0	root	_	_
19	with	with	IN	IN	_	26	mark	_	_
20	a	a	DT	DT	_	22	det	_	_
21	small	small	JJ	JJ	_	22	amod	_	_
22	number	number	NN	NN	_	26	nsubj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	having	have	VBG	VBG	_	18	advcl	_	_
27	eosinophilic	eosinophilic	JJ	JJ	_	28	amod	_	_
28	granules	granule	NNS	NNS	_	26	dobj	_	_
29	.	.	.	.	_	18	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	surface	surface	NN	NN	_	3	compound	_	_
3	markers	marker	NNS	NNS	_	9	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	YJ	yj	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	positive	positive	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	CD33	cd33	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	negative	negative	JJ	JJ	_	9	conj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	CD34	cd34	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	CD16	cd16	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	CD23	cd23	NN	NN	_	16	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	eosinophilic	eosinophilic	JJ	JJ	_	3	amod	_	_
3	characteristics	characteristic	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	YJ	yj	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	confirmed	confirm	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	histochemical	histochemical	JJ	JJ	_	11	amod	_	_
11	staining	staining	NN	NN	_	8	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Fast-Green/Neutral-Red	fast-green/neutral-red	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	expression	expression	NN	NN	_	11	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	mRNAs	mrna	NNS	NNS	_	17	nmod	_	_
20	for	for	IN	IN	_	23	case	_	_
21	eosinophil-associated	eosinophil-associated	JJ	JJ	_	23	amod	_	_
22	granule	granule	NN	NN	_	23	compound	_	_
23	proteins	protein	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	eosinophil	eosinophil	NN	NN	_	27	compound	_	_
26	cationic	cationic	JJ	JJ	_	27	amod	_	_
27	protein	protein	NN	NN	_	23	conj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	ECP	ecp	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	23	punct	_	_
32	eosinophil-derived	eosinophil-derived	JJ	JJ	_	33	amod	_	_
33	neurotoxin	neurotoxin	NN	NN	_	23	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	EDN	edn	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	,	,	,	,	_	23	punct	_	_
38	eosinophil	eosinophil	NN	NN	_	39	compound	_	_
39	peroxidase	peroxidase	NN	NN	_	23	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	EPO	epo	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	,	,	,	,	_	23	punct	_	_
44	and	and	CC	CC	_	23	cc	_	_
45	major	major	JJ	JJ	_	47	amod	_	_
46	basic	basic	JJ	JJ	_	47	amod	_	_
47	protein	protein	NN	NN	_	23	conj	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	MBP	mbp	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	,	,	,	,	_	23	punct	_	_
52	and	and	CC	CC	_	23	cc	_	_
53	for	for	IN	IN	_	60	case	_	_
54	the	the	DT	DT	_	60	det	_	_
55	Charcot-Leyden	charcot-leyden	NN	NN	_	60	compound	_	_
56	crystal	crystal	NN	NN	_	60	compound	_	_
57	(	(	-LRB-	-LRB-	_	60	punct	_	_
58	CLC	clc	NN	NN	_	60	compound	_	_
59	)	)	-RRB-	-RRB-	_	60	punct	_	_
60	protein	protein	NN	NN	_	23	conj	_	_
61	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	YJ	yj	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	6	nsubjpass	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	towards	towards	IN	IN	_	9	case	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	stimulation	stimulation	NN	NN	_	6	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	phorbol	phorbol	NN	NN	_	15	compound	_	_
14	12-myristate	12-myristate	NN	NN	_	15	compound	_	_
15	13-acetate	13-acetate	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMA	pma	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	monocytic	monocytic	JJ	JJ	_	3	amod	_	_
3	characteristics	characteristic	NNS	NNS	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	YJ	yj	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	treated	treat	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	PMA	pma	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	confirmed	confirm	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	morphological	morphological	JJ	JJ	_	14	amod	_	_
14	analysis	analysis	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	alpha-naphthyl	alpha-naphthyl	NN	NN	_	19	compound	_	_
17	butyrate	butyrate	NN	NN	_	19	compound	_	_
18	esterase	esterase	NN	NN	_	19	compound	_	_
19	staining	staining	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	14	punct	_	_
21	by	by	IN	IN	_	23	case	_	_
22	CD14	cd14	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	14	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	by	by	IN	IN	_	28	case	_	_
27	increased	increase	VBN	VBN	_	28	amod	_	_
28	expression	expression	NN	NN	_	14	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	Egr-1	egr-1	NN	NN	_	31	compound	_	_
31	mRNA	mrna	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	11	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	YJ	yj	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
5	could	could	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	differentiated	differentiate	VBN	VBN	_	0	root	_	_
8	towards	towards	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	neutrophil	neutrophil	NN	NN	_	11	compound	_	_
11	lineage	lineage	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	stimulation	stimulation	NN	NN	_	7	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	all-trans	all-trans	JJ	JJ	_	17	amod	_	_
16	retinoic	retinoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	RA	ra	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	7	punct	_	_

1	YJ	yj	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	10	nsubj	_	_
3	treated	treat	VBN	VBN	_	2	acl	_	_
4	in	in	FW	FW	_	5	compound	_	_
5	vitro	vitro	FW	FW	_	3	advmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	2	2	CD	CD	_	8	compound	_	_
8	microM	microm	NN	NN	_	9	amod	_	_
9	RA	ra	NN	NN	_	3	nmod	_	_
10	differentiated	differentiate	VBD	VBD	_	0	root	_	_
11	into	into	IN	IN	_	12	case	_	_
12	metamyelocytes	metamyelocyte	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	band	band	NN	NN	_	15	compound	_	_
15	neutrophils	neutrophil	NNS	NNS	_	12	conj	_	_
16	,	,	,	,	_	10	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	increased	increase	VBD	VBD	_	10	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	number	number	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	28	case	_	_
22	nitroblue	nitroblue	JJ	JJ	_	28	amod	_	_
23	tetrazolium	tetrazolium	NN	NN	_	28	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	NBT	nbt	NN	NN	_	28	compound	_	_
26	)	)	-RRB-	-RRB-	_	28	punct	_	_
27	-positive	-positive	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	20	nmod	_	_
29	and	and	CC	CC	_	10	cc	_	_
30	increased	increase	VBD	VBD	_	10	conj	_	_
31	gp91phox	gp91phox	NN	NN	_	33	compound	_	_
32	mRNA	mrna	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	YJ	yj	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	7	nsubj	_	_
7	exhibited	exhibit	VBD	VBD	_	0	root	_	_
8	eosinophilic	eosinophilic	JJ	JJ	_	9	amod	_	_
9	characteristics	characteristic	NNS	NNS	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	was	be	VBD	VBD	_	13	cop	_	_
13	able	able	JJ	JJ	_	7	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	differentiate	differentiate	VB	VB	_	13	xcomp	_	_
16	to	to	TO	TO	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	neutrophilic	neutrophilic	JJ	JJ	_	18	conj	_	_
21	lineages	lineage	NNS	NNS	_	15	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	response	response	NN	NN	_	25	dep	_	_
24	to	to	TO	TO	_	25	case	_	_
25	PMA	pma	NN	NN	_	15	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	RA	ra	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	respectively	respectively	RB	RB	_	25	advmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	genes	gene	NNS	NNS	_	2	nmod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	evaluated	evaluate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	17	case	_	_
15	Northern	northern	NN	NN	_	17	compound	_	_
16	blot	blot	NN	NN	_	17	compound	_	_
17	analysis	analysis	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Egr-1	egr-1	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	macrophage	macrophage	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	increased	increase	VBN	VBN	_	5	amod	_	_
5	expressions	expression	NNS	NNS	_	11	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	C/EBPbeta	c/ebpbeta	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	MZF-1	mzf-1	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	conj	_	_
11	occurred	occur	VBD	VBD	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	neutrophilic	neutrophilic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	YJ	yj	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	line	line	NN	NN	_	7	nsubj	_	_
5	should	should	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	useful	useful	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	9	mark	_	_
9	elucidating	elucidate	VBG	VBG	_	7	advcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	molecular	molecular	JJ	JJ	_	12	amod	_	_
12	mechanisms	mechanism	NNS	NNS	_	9	dobj	_	_
13	governing	govern	VBG	VBG	_	12	acl	_	_
14	lineage	lineage	NN	NN	_	15	compound	_	_
15	switching	switching	NN	NN	_	13	dobj	_	_
16	from	from	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	eosinophil	eosinophil	NN	NN	_	15	nmod	_	_
19	to	to	TO	TO	_	20	case	_	_
20	monocytic	monocytic	JJ	JJ	_	15	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	neutrophil	neutrophil	NN	NN	_	20	conj	_	_
23	lineages	lineage	NNS	NNS	_	15	dep	_	_
24	.	.	.	.	_	7	punct	_	_

1	Low	low	JJ	JJ	_	4	amod	_	_
2	CD3+CD28-induced	cd3+cd28-induced	JJ	JJ	_	4	amod	_	_
3	interleukin-2	interleukin-2	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	5	nsubj	_	_
5	correlates	correlate	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	11	case	_	_
7	decreased	decrease	VBN	VBN	_	11	amod	_	_
8	reactive	reactive	JJ	JJ	_	11	amod	_	_
9	oxygen	oxygen	NN	NN	_	11	compound	_	_
10	intermediate	intermediate	JJ	JJ	_	11	amod	_	_
11	formation	formation	NN	NN	_	5	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	neonatal	neonatal	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	capacity	capacity	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	neonatal	neonatal	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	secrete	secrete	VB	VB	_	2	acl	_	_
9	interleukin-2	interleukin-2	NN	NN	_	8	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-2	il-2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	reported	report	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	variable	variable	JJ	JJ	_	15	xcomp	_	_
19	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analysed	analyse	VBD	VBD	_	0	root	_	_
3	IL-2	il-2	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	11	case	_	_
6	purified	purify	VBN	VBN	_	11	amod	_	_
7	neonatal	neonatal	JJ	JJ	_	11	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	adult	adult	JJ	JJ	_	7	conj	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	using	use	VBG	VBG	_	2	xcomp	_	_
13	polyclonal	polyclonal	JJ	JJ	_	16	amod	_	_
14	activator	activator	NN	NN	_	16	compound	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	12	dobj	_	_
17	+	+	CC	CC	_	16	cc	_	_
18	calcium	calcium	NN	NN	_	19	compound	_	_
19	ionophore	ionophore	NN	NN	_	16	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PDBu	pdbu	NN	NN	_	16	appos	_	_
22	+	+	CC	CC	_	21	cc	_	_
23	iono	iono	NN	NN	_	21	conj	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	or	or	CC	CC	_	16	cc	_	_
26	receptor-mediated	receptor-mediated	JJ	JJ	_	29	amod	_	_
27	anti-CD3/anti-CD3+	anti-cd3/anti-cd3+	JJ	JJ	_	29	amod	_	_
28	anti-CD28	anti-cd28	JJ	JJ	_	29	amod	_	_
29	stimulation	stimulation	NN	NN	_	16	conj	_	_
30	.	.	.	.	_	2	punct	_	_

1	PDBu	pdbu	NN	NN	_	4	nsubj	_	_
2	+	+	CC	CC	_	1	cc	_	_
3	iono	iono	NN	NN	_	1	conj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	equally	equally	RB	RB	_	6	advmod	_	_
6	high	high	JJ	JJ	_	8	amod	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	both	both	DT	DT	_	11	det	_	_
11	groups	group	NNS	NNS	_	4	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	,	,	,	,	_	4	punct	_	_
14	when	when	WRB	WRB	_	15	advmod	_	_
15	stimulated	stimulate	VBN	VBN	_	32	advcl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	plate-bound	plate-bound	JJ	JJ	_	20	amod	_	_
18	anti-CD3	anti-cd3	JJ	JJ	_	20	amod	_	_
19	monoclonal	monoclonal	JJ	JJ	_	20	amod	_	_
20	antibody	antibody	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	mAb	mab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	32	punct	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IL-2	il-2	NN	NN	_	27	compound	_	_
27	secretion	secretion	NN	NN	_	32	nsubj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	neonatal	neonatal	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	was	be	VBD	VBD	_	32	cop	_	_
32	undetectable	undetectable	JJ	JJ	_	4	conj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	adult	adult	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	36	nsubj	_	_
36	produced	produce	VBD	VBD	_	32	conj	_	_
37	low	low	JJ	JJ	_	38	amod	_	_
38	amounts	amount	NNS	NNS	_	36	dobj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	IL-2	il-2	NN	NN	_	38	nmod	_	_
41	(	(	-LRB-	-LRB-	_	46	punct	_	_
42	mean	mean	NN	NN	_	46	dep	_	_
43	331	331	CD	CD	_	46	nummod	_	_
44	+/-	+/-	CC	CC	_	43	cc	_	_
45	86	86	CD	CD	_	43	conj	_	_
46	pg/ml	pg/ml	NN	NN	_	38	dep	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	.	.	.	.	_	32	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	anti-CD28	anti-cd28	JJ	JJ	_	5	amod	_	_
5	mAb	mab	NN	NN	_	2	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	anti-CD3-stimulated	anti-cd3-stimulated	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	increased	increase	VBD	VBD	_	0	root	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	both	both	DT	DT	_	16	det	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	types	type	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	but	but	CC	CC	_	10	cc	_	_
19	levels	level	NNS	NNS	_	26	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-2	il-2	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	neonatal	neonatal	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	remained	remain	VBD	VBD	_	10	conj	_	_
27	clearly	clearly	RB	RB	_	26	advmod	_	_
28	lower	lower	JJR	JJR	_	26	xcomp	_	_
29	than	than	IN	IN	_	30	case	_	_
30	those	those	DT	DT	_	28	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	adult	adult	JJ	JJ	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	(	(	-LRB-	-LRB-	_	43	punct	_	_
36	respective	respective	JJ	JJ	_	38	amod	_	_
37	mean	mean	JJ	JJ	_	38	amod	_	_
38	values	value	NNS	NNS	_	43	dep	_	_
39	:	:	:	:	_	43	punct	_	_
40	385	385	CD	CD	_	43	nummod	_	_
41	+/-	+/-	CC	CC	_	40	cc	_	_
42	109	109	CD	CD	_	40	conj	_	_
43	pg/ml	pg/ml	NN	NN	_	26	parataxis	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	4494	4494	CD	CD	_	48	nummod	_	_
46	+/-	+/-	CC	CC	_	45	cc	_	_
47	1199	1199	CD	CD	_	45	conj	_	_
48	pg/ml	pg/ml	NN	NN	_	43	conj	_	_
49	)	)	-RRB-	-RRB-	_	43	punct	_	_
50	.	.	.	.	_	26	punct	_	_

1	As	as	IN	IN	_	8	mark	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	critical	critical	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	18	advcl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	control	control	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	IL-2	il-2	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	next	next	RB	RB	_	18	advmod	_	_
18	analysed	analyse	VBD	VBD	_	0	root	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	translocation	translocation	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	27	case	_	_
23	neonatal	neonatal	JJ	JJ	_	27	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	adult	adult	JJ	JJ	_	23	conj	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	21	nmod	_	_
28	using	use	VBG	VBG	_	18	xcomp	_	_
29	the	the	DT	DT	_	33	det	_	_
30	electrophoretic	electrophoretic	JJ	JJ	_	33	amod	_	_
31	mobility	mobility	NN	NN	_	33	compound	_	_
32	shift	shift	NN	NN	_	33	compound	_	_
33	assay	assay	NN	NN	_	28	dobj	_	_
34	and	and	CC	CC	_	18	cc	_	_
35	,	,	,	,	_	18	punct	_	_
36	because	because	IN	IN	_	46	mark	_	_
37	induction	induction	NN	NN	_	46	nsubjpass	_	_
38	of	of	IN	IN	_	41	case	_	_
39	reactive	reactive	JJ	JJ	_	41	amod	_	_
40	oxygen	oxygen	NN	NN	_	41	compound	_	_
41	intermediates	intermediate	NNS	NNS	_	37	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	ROI	rous	NNS	NNS	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	is	be	VBZ	VBZ	_	46	auxpass	_	_
46	required	require	VBN	VBN	_	56	advcl	_	_
47	for	for	IN	IN	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	activation	activation	NN	NN	_	46	nmod	_	_
50	of	of	IN	IN	_	52	case	_	_
51	NF-kappa	nf-kappa	NN	NN	_	52	compound	_	_
52	B	b	NN	NN	_	49	nmod	_	_
53	,	,	,	,	_	56	punct	_	_
54	we	we	PRP	PRP	_	56	nsubj	_	_
55	also	also	RB	RB	_	56	advmod	_	_
56	analysed	analyse	VBD	VBD	_	18	conj	_	_
57	levels	level	NNS	NNS	_	56	dobj	_	_
58	of	of	IN	IN	_	60	case	_	_
59	intracellular	intracellular	JJ	JJ	_	60	amod	_	_
60	ROI	rous	NNS	NNS	_	57	nmod	_	_
61	in	in	IN	IN	_	63	case	_	_
62	these	these	DT	DT	_	63	det	_	_
63	cells	cell	NNS	NNS	_	57	nmod	_	_
64	using	use	VBG	VBG	_	56	xcomp	_	_
65	the	the	DT	DT	_	68	det	_	_
66	ROI-reactive	roi-reactive	JJ	JJ	_	68	amod	_	_
67	fluorochrome	fluorochrome	NN	NN	_	68	compound	_	_
68	DCFH-DA	dcfh-da	NN	NN	_	64	dobj	_	_
69	and	and	CC	CC	_	68	cc	_	_
70	flow	flow	NN	NN	_	71	compound	_	_
71	cytometry	cytometry	NN	NN	_	68	conj	_	_
72	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	neonatal	neonatal	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	15	nmod	_	_
5	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	15	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ROI	rous	NNS	NNS	_	10	compound	_	_
10	formation	formation	NN	NN	_	7	conj	_	_
11	after	after	IN	IN	_	13	case	_	_
12	anti-CD3	anti-cd3	JJ	JJ	_	13	amod	_	_
13	stimulation	stimulation	NN	NN	_	7	nmod	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	low	low	JJ	JJ	_	0	root	_	_
16	compared	compare	VBN	VBN	_	20	case	_	_
17	with	with	IN	IN	_	20	case	_	_
18	adult	adult	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	advcl	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	,	,	,	,	_	15	punct	_	_
23	although	although	IN	IN	_	28	mark	_	_
24	addition	addition	NN	NN	_	28	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	anti-CD28	anti-cd28	JJ	JJ	_	27	amod	_	_
27	mAb	mab	NN	NN	_	24	nmod	_	_
28	increased	increase	VBD	VBD	_	45	advcl	_	_
29	induction	induction	NN	NN	_	28	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	ROI	rous	NNS	NNS	_	35	compound	_	_
35	formation	formation	NN	NN	_	29	conj	_	_
36	,	,	,	,	_	45	punct	_	_
37	levels	level	NNS	NNS	_	45	nsubjpass	_	_
38	similar	similar	JJ	JJ	_	37	amod	_	_
39	to	to	TO	TO	_	40	case	_	_
40	those	those	DT	DT	_	38	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	adults	adult	NNS	NNS	_	40	nmod	_	_
43	were	be	VBD	VBD	_	45	auxpass	_	_
44	not	not	RB	RB	_	45	neg	_	_
45	achieved	achieve	VBN	VBN	_	15	conj	_	_
46	.	.	.	.	_	45	punct	_	_

1	After	after	IN	IN	_	5	case	_	_
2	PDBu	pdbu	NN	NN	_	5	compound	_	_
3	+	+	CC	CC	_	2	cc	_	_
4	iono	iono	NN	NN	_	2	conj	_	_
5	stimulation	stimulation	NN	NN	_	9	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	similar	similar	JJ	JJ	_	12	amod	_	_
11	ROI	rous	NNS	NNS	_	12	compound	_	_
12	formation	formation	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	secretion	secretion	NN	NN	_	12	conj	_	_
16	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	reduced	reduce	VBN	VBN	_	7	amod	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	13	nsubj	_	_
8	by	by	IN	IN	_	11	case	_	_
9	neonatal	neonatal	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	specific	specific	JJ	JJ	_	3	ccomp	_	_
14	for	for	IN	IN	_	19	case	_	_
15	anti-CD3	anti-cd3	JJ	JJ	_	18	nmod:npmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	anti-CD3+	anti-cd3+	JJ	JJ	_	15	conj	_	_
18	anti-CD28-mediated	anti-cd28-mediated	JJ	JJ	_	19	amod	_	_
19	stimulation	stimulation	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	that	that	IN	IN	_	27	mark	_	_
22	these	these	DT	DT	_	23	det	_	_
23	activators	activator	NNS	NNS	_	27	nsubj	_	_
24	can	can	MD	MD	_	27	aux	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	effectively	effectively	RB	RB	_	27	advmod	_	_
27	activate	activate	VB	VB	_	13	conj	_	_
28	the	the	DT	DT	_	32	det	_	_
29	ROI-NF-kappa	roi-nf-kappa	NN	NN	_	32	compound	_	_
30	B	b	NN	NN	_	32	compound	_	_
31	signalling	signalling	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	27	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	neonatal	neonatal	JJ	JJ	_	36	amod	_	_
35	T	t	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	AD1	ad1	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	AD2	ad2	NN	NN	_	6	compound	_	_
5	transactivation	transactivation	NN	NN	_	6	compound	_	_
6	domains	domain	NNS	NNS	_	2	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	E2A	e2a	NN	NN	_	2	nmod	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	essential	essential	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	antiapoptotic	antiapoptotic	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	chimeric	chimeric	JJ	JJ	_	19	amod	_	_
18	oncoprotein	oncoprotein	NN	NN	_	19	compound	_	_
19	E2A-HLF	e2a-hlf	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	chimeric	chimeric	JJ	JJ	_	4	amod	_	_
3	oncoprotein	oncoprotein	NN	NN	_	4	compound	_	_
4	E2A-HLF	e2a-hlf	NN	NN	_	18	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	generated	generate	VBN	VBN	_	4	acl	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	t(17;19)	t(17;19)	NN	NN	_	11	compound	_	_
10	chromosomal	chromosomal	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	pro-B-cell	pro-b-cell	JJ	JJ	_	16	amod	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	lymphoblastic	lymphoblastic	JJ	JJ	_	16	amod	_	_
16	leukemia	leukemia	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	incorporates	incorporate	VBZ	VBZ	_	0	root	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transactivation	transactivation	NN	NN	_	21	compound	_	_
21	domains	domain	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	E2A	e2a	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	the	the	DT	DT	_	32	det	_	_
26	basic	basic	JJ	JJ	_	28	amod	_	_
27	leucine	leucine	NN	NN	_	28	compound	_	_
28	zipper	zipper	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	bZIP	bzip	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	DNA-binding	dna-binding	NN	NN	_	21	conj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	protein	protein	NN	NN	_	36	compound	_	_
35	dimerization	dimerization	NN	NN	_	36	compound	_	_
36	domain	domain	NN	NN	_	32	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	HLF	hlf	NN	NN	_	32	nmod	_	_
39	(	(	-LRB-	-LRB-	_	42	punct	_	_
40	hepatic	hepatic	JJ	JJ	_	42	amod	_	_
41	leukemic	leukemic	JJ	JJ	_	42	amod	_	_
42	factor	factor	NN	NN	_	38	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E2A-HLF	e2a-hlf	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	prolong	prolong	VB	VB	_	2	acl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	survival	survival	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	17	case	_	_
10	interleukin-3	interleukin-3	NN	NN	_	17	compound	_	_
11	(	(	-LRB-	-LRB-	_	17	punct	_	_
12	IL-3	il-3	NN	NN	_	17	compound	_	_
13	)	)	-RRB-	-RRB-	_	17	punct	_	_
14	-dependent	-dependent	JJ	JJ	_	17	amod	_	_
15	murine	murine	JJ	JJ	_	17	amod	_	_
16	pro-B	pro-b	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	8	nmod	_	_
18	after	after	IN	IN	_	20	case	_	_
19	IL-3	il-3	NN	NN	_	20	compound	_	_
20	withdrawal	withdrawal	NN	NN	_	8	nmod	_	_
21	suggests	suggest	VBZ	VBZ	_	0	root	_	_
22	that	that	IN	IN	_	24	mark	_	_
23	it	it	PRP	PRP	_	24	nsubj	_	_
24	disrupts	disrupt	VBZ	VBZ	_	21	ccomp	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	pathways	pathway	NNS	NNS	_	24	dobj	_	_
27	normally	normally	RB	RB	_	28	advmod	_	_
28	responsible	responsible	JJ	JJ	_	26	amod	_	_
29	for	for	IN	IN	_	31	case	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	suicide	suicide	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	24	punct	_	_
33	allowing	allow	VBG	VBG	_	24	advcl	_	_
34	the	the	DT	DT	_	35	det	_	_
35	cells	cell	NNS	NNS	_	33	dobj	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	accumulate	accumulate	VB	VB	_	33	xcomp	_	_
38	as	as	IN	IN	_	40	case	_	_
39	transformed	transform	VBN	VBN	_	40	amod	_	_
40	lymphoblasts	lymphoblast	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	21	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	14	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	structural	structural	JJ	JJ	_	5	amod	_	_
5	motifs	motif	NNS	NNS	_	2	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	contribute	contribute	VBP	VBP	_	5	acl:relcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	this	this	DT	DT	_	11	det	_	_
10	antiapoptotic	antiapoptotic	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	constructed	construct	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	16	det	_	_
16	panel	panel	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	E2A-HLF	e2a-hlf	NN	NN	_	19	compound	_	_
19	mutants	mutant	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	programmed	program	VBD	VBD	_	14	conj	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	IL-3-dependent	il-3-dependent	JJ	JJ	_	28	amod	_	_
26	murine	murine	JJ	JJ	_	28	amod	_	_
27	pro-B	pro-b	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	FL5.12	fl5.12	NN	NN	_	31	compound	_	_
31	line	line	NN	NN	_	28	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	21	punct	_	_
34	using	use	VBG	VBG	_	21	advcl	_	_
35	a	a	DT	DT	_	37	det	_	_
36	zinc-inducible	zinc-inducible	JJ	JJ	_	37	amod	_	_
37	vector	vector	NN	NN	_	34	dobj	_	_
38	.	.	.	.	_	14	punct	_	_

1	Neither	neither	RB	RB	_	3	advmod	_	_
2	the	the	DT	DT	_	3	det	_	_
3	E12	e12	NN	NN	_	18	nsubj	_	_
4	nor	nor	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	6	det	_	_
6	E47	e47	NN	NN	_	3	conj	_	_
7	product	product	NN	NN	_	3	dep	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	E2A	e2a	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	nor	nor	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	16	det	_	_
14	wild-type	wild-type	JJ	JJ	_	16	amod	_	_
15	HLF	hlf	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	11	conj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	able	able	JJ	JJ	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	protect	protect	VB	VB	_	18	xcomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cells	cell	NNS	NNS	_	20	dobj	_	_
23	from	from	IN	IN	_	24	case	_	_
24	apoptosis	apoptosis	NN	NN	_	20	nmod	_	_
25	induced	induce	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	IL-3	il-3	NN	NN	_	28	compound	_	_
28	deprivation	deprivation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	18	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	different	different	JJ	JJ	_	4	amod	_	_
4	combinations	combination	NNS	NNS	_	13	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	disabling	disable	VBG	VBG	_	7	amod	_	_
7	mutations	mutation	NNS	NNS	_	4	nmod	_	_
8	within	within	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	HLF	hlf	NN	NN	_	12	compound	_	_
11	bZIP	bzip	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	7	nmod	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	little	little	JJ	JJ	_	15	amod	_	_
15	effect	effect	NN	NN	_	13	dobj	_	_
16	on	on	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	antiapoptotic	antiapoptotic	JJ	JJ	_	19	amod	_	_
19	property	property	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	chimeric	chimeric	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	13	punct	_	_
25	so	so	RB	RB	_	26	advmod	_	_
26	long	long	RB	RB	_	13	advmod	_	_
27	as	as	IN	IN	_	33	mark	_	_
28	the	the	DT	DT	_	30	det	_	_
29	amino-terminal	amino-terminal	JJ	JJ	_	30	amod	_	_
30	portion	portion	NN	NN	_	33	nsubj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	E2A	e2a	NN	NN	_	30	nmod	_	_
33	remained	remain	VBD	VBD	_	26	advcl	_	_
34	intact	intact	JJ	JJ	_	33	xcomp	_	_
35	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	the	the	DT	DT	_	7	dep	_	_
3	context	context	NN	NN	_	7	dep	_	_
4	of	of	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	bZIP	bzip	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	24	nmod	_	_
8	defective	defective	JJ	JJ	_	7	amod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	DNA	dna	NN	NN	_	11	compound	_	_
11	binding	binding	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	24	punct	_	_
13	mutants	mutant	NNS	NNS	_	24	nsubj	_	_
14	retaining	retain	VBG	VBG	_	13	acl	_	_
15	either	either	DT	DT	_	14	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	two	two	CD	CD	_	20	nummod	_	_
19	transactivation	transactivation	NN	NN	_	20	compound	_	_
20	domains	domain	NNS	NNS	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	E2A	e2a	NN	NN	_	20	nmod	_	_
23	were	be	VBD	VBD	_	24	cop	_	_
24	able	able	JJ	JJ	_	0	root	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	extend	extend	VB	VB	_	24	xcomp	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	survival	survival	NN	NN	_	26	dobj	_	_
29	after	after	IN	IN	_	32	case	_	_
30	growth	growth	NN	NN	_	32	compound	_	_
31	factor	factor	NN	NN	_	32	compound	_	_
32	deprivation	deprivation	NN	NN	_	26	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	Thus	thus	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	block	block	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	apoptosis	apoptosis	NN	NN	_	4	nmod	_	_
7	imposed	impose	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	E2A-HLF	e2a-hlf	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	pro-B	pro-b	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	depends	depend	VBZ	VBZ	_	0	root	_	_
14	critically	critically	RB	RB	_	18	advmod	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transactivating	transactivating	JJ	JJ	_	18	amod	_	_
18	regions	region	NNS	NNS	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	E2A	e2a	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Since	since	IN	IN	_	15	mark	_	_
2	neither	neither	CC	CC	_	4	cc:preconj	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	15	nsubjpass	_	_
5	nor	nor	CC	CC	_	4	cc	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	dimerization	dimerization	NN	NN	_	4	conj	_	_
8	through	through	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	bZIP	bzip	NN	NN	_	11	compound	_	_
11	domain	domain	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HLF	hlf	NN	NN	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	21	advcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	propose	propose	VBP	VBP	_	0	root	_	_
22	mechanisms	mechanism	NNS	NNS	_	21	dobj	_	_
23	whereby	whereby	IN	IN	_	32	advmod	_	_
24	protein-protein	protein-protein	JJ	JJ	_	25	amod	_	_
25	interactions	interaction	NNS	NNS	_	32	nsubj	_	_
26	with	with	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	amino-terminal	amino-terminal	JJ	JJ	_	29	amod	_	_
29	region	region	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	E2A	e2a	NN	NN	_	29	nmod	_	_
32	allow	allow	VBP	VBP	_	22	dep	_	_
33	the	the	DT	DT	_	34	det	_	_
34	chimera	chimera	NN	NN	_	32	dobj	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	act	act	VB	VB	_	32	xcomp	_	_
37	as	as	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	cofactor	cofactor	NN	NN	_	36	nmod	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	alter	alter	VB	VB	_	40	acl	_	_
43	the	the	DT	DT	_	44	det	_	_
44	expression	expression	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	46	case	_	_
46	genes	gene	NNS	NNS	_	44	nmod	_	_
47	regulating	regulate	VBG	VBG	_	46	acl	_	_
48	the	the	DT	DT	_	50	det	_	_
49	apoptotic	apoptotic	JJ	JJ	_	50	amod	_	_
50	machinery	machinery	NN	NN	_	47	dobj	_	_
51	in	in	IN	IN	_	53	case	_	_
52	pro-B	pro-b	JJ	JJ	_	53	amod	_	_
53	cells	cell	NNS	NNS	_	44	nmod	_	_
54	.	.	.	.	_	21	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T	t	NN	NN	_	5	compound	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	leukemia	leukemia	NN	NN	_	5	compound	_	_
5	virus-I	virus-i	NN	NN	_	9	nmod:npmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HTLV-I	htlv-i	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	Tax-mediated	tax-mediated	JJ	JJ	_	10	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	15	nsubj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	an	a	DT	DT	_	20	det	_	_
17	enhanced	enhance	VBN	VBN	_	20	amod	_	_
18	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
19	prooxidant	prooxidant	JJ	JJ	_	20	amod	_	_
20	state	state	NN	NN	_	15	dobj	_	_
21	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	an	a	DT	DT	_	7	det	_	_
6	estradiol-dependent	estradiol-dependent	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	15	nsubj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	human	human	JJ	JJ	_	14	amod	_	_
10	T	t	NN	NN	_	14	compound	_	_
11	cell	cell	NN	NN	_	14	compound	_	_
12	leukemia	leukemia	NN	NN	_	14	compound	_	_
13	virus-I	virus-i	NN	NN	_	14	compound	_	_
14	Tax	tax	NN	NN	_	7	nmod	_	_
15	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	inhibition	inhibition	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	proliferation	proliferation	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	induction	induction	NN	NN	_	18	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	apoptosis	apoptosis	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	a	a	DT	DT	_	8	det	_	_
7	hormone-dependent	hormone-dependent	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Tax	tax	NN	NN	_	8	nmod	_	_
11	promotes	promote	VBZ	VBZ	_	4	ccomp	_	_
12	an	a	DT	DT	_	15	det	_	_
13	enhanced	enhance	VBN	VBN	_	15	amod	_	_
14	prooxidant	prooxidant	JJ	JJ	_	15	amod	_	_
15	state	state	NN	NN	_	11	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	stably	stably	RB	RB	_	20	advmod	_	_
18	transfected	transfect	VBN	VBN	_	20	amod	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	as	as	IN	IN	_	22	mark	_	_
22	measured	measure	VBN	VBN	_	11	advcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	changes	change	NNS	NNS	_	22	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	intracellular	intracellular	JJ	JJ	_	28	amod	_	_
28	levels	level	NNS	NNS	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	glutathione	glutathione	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	H2O2	h2o2	NN	NN	_	30	conj	_	_
33	;	;	:	:	_	4	punct	_	_
34	these	these	DT	DT	_	35	det	_	_
35	changes	change	NNS	NNS	_	37	nsubjpass	_	_
36	are	be	VBP	VBP	_	37	auxpass	_	_
37	followed	follow	VBN	VBN	_	4	parataxis	_	_
38	by	by	IN	IN	_	41	case	_	_
39	apoptotic	apoptotic	JJ	JJ	_	41	amod	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	death	death	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	4	punct	_	_

1	Additional	additional	JJ	JJ	_	2	amod	_	_
2	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD3/TCR	cd3/tcr	NN	NN	_	6	compound	_	_
6	pathway	pathway	NN	NN	_	2	nmod	_	_
7	enhances	enhance	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	12	det	_	_
9	oxidative	oxidative	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	apoptotic	apoptotic	JJ	JJ	_	9	conj	_	_
12	effects	effect	NNS	NNS	_	7	dobj	_	_
13	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	Tax-mediated	tax-mediated	JJ	JJ	_	3	amod	_	_
3	apoptosis	apoptosis	NN	NN	_	10	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	oxidative	oxidative	JJ	JJ	_	6	amod	_	_
6	stress	stress	NN	NN	_	3	conj	_	_
7	can	can	MD	MD	_	10	aux	_	_
8	be	be	VB	VB	_	10	auxpass	_	_
9	potently	potently	RB	RB	_	10	advmod	_	_
10	suppressed	suppress	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	antioxidants	antioxidant	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	as	as	IN	IN	_	16	mark	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	seen	see	VBN	VBN	_	10	advcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	administration	administration	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	recombinant	recombinant	JJ	JJ	_	22	amod	_	_
22	thioredoxin	thioredoxin	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	28	punct	_	_
24	adult	adult	JJ	JJ	_	28	amod	_	_
25	T	t	NN	NN	_	28	compound	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	leukemia-derived	leukemia-derived	JJ	JJ	_	28	amod	_	_
28	factor	factor	NN	NN	_	22	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	or	or	CC	CC	_	22	cc	_	_
31	pyrrolidine	pyrrolidine	NN	NN	_	32	compound	_	_
32	dithiocarbamate	dithiocarbamate	NN	NN	_	22	conj	_	_
33	.	.	.	.	_	10	punct	_	_

1	Hormone-induced	hormone-induced	JJ	JJ	_	3	amod	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	long-lasting	long-lasting	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	15	nsubj	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	major	major	JJ	JJ	_	15	amod	_	_
15	target	target	NN	NN	_	9	acl:relcl	_	_
16	of	of	IN	IN	_	19	case	_	_
17	reactive	reactive	JJ	JJ	_	19	amod	_	_
18	oxygen	oxygen	NN	NN	_	19	compound	_	_
19	intermediates	intermediate	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	long-term	long-term	JJ	JJ	_	3	amod	_	_
3	exposure	exposure	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	Jurkat	jurkat	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	hormone	hormone	NN	NN	_	3	nmod	_	_
9	eventually	eventually	RB	RB	_	10	advmod	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	selection	selection	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	clones	clone	NNS	NNS	_	13	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	have	have	VBP	VBP	_	19	aux	_	_
19	lost	lose	VBN	VBN	_	16	acl:relcl	_	_
20	Tax	tax	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	subsequent	subsequent	JJ	JJ	_	3	amod	_	_
3	transfection	transfection	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	these	these	DT	DT	_	9	det	_	_
6	apparently	apparently	RB	RB	_	8	advmod	_	_
7	``	``	``	``	_	8	punct	_	_
8	nonresponsive	nonresponsive	JJ	JJ	_	9	amod	_	_
9	clones	clone	NNS	NNS	_	3	nmod	_	_
10	allows	allow	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	recovery	recovery	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Tax	tax	NN	NN	_	15	compound	_	_
15	responses	response	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	changes	change	NNS	NNS	_	15	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
9	redox	redox	NN	NN	_	10	compound	_	_
10	status	status	NN	NN	_	5	nmod	_	_
11	may	may	MD	MD	_	15	aux	_	_
12	be	be	VB	VB	_	15	cop	_	_
13	a	a	DT	DT	_	15	det	_	_
14	determining	determine	VBG	VBG	_	15	amod	_	_
15	factor	factor	NN	NN	_	3	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	Tax-mediated	tax-mediated	JJ	JJ	_	19	amod	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	damage	damage	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	apoptosis	apoptosis	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	selection	selection	NN	NN	_	19	conj	_	_
25	against	against	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	long-term	long-term	JJ	JJ	_	28	amod	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	Tax	tax	NN	NN	_	31	compound	_	_
31	function	function	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	platelets	platelet	NNS	NNS	_	3	nsubj	_	_
3	induce	induce	VBP	VBP	_	0	root	_	_
4	monocyte	monocyte	NN	NN	_	7	compound	_	_
5	chemotactic	chemotactic	JJ	JJ	_	7	amod	_	_
6	protein-1	protein-1	NN	NN	_	7	compound	_	_
7	secretion	secretion	NN	NN	_	3	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	intercellular	intercellular	JJ	JJ	_	14	amod	_	_
13	adhesion	adhesion	NN	NN	_	14	compound	_	_
14	molecule-1	molecule-1	NN	NN	_	10	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	endothelial	endothelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	3	nmod	_	_
18	-LSB-	-lsb-	-LRB-	-LRB-	_	19	punct	_	_
19	see	see	VB	VB	_	3	parataxis	_	_
20	comments	comment	NNS	NNS	_	19	dobj	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	19	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Platelet/endothelium	platelet/endothelium	NN	NN	_	4	compound	_	_
4	interaction	interaction	NN	NN	_	5	nsubj	_	_
5	plays	play	VBZ	VBZ	_	1	appos	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	pathophysiology	pathophysiology	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	inflammation	inflammation	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	atherosclerosis	atherosclerosis	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	28	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	platelets	platelet	NNS	NNS	_	2	nmod	_	_
5	for	for	IN	IN	_	12	case	_	_
6	monocyte	monocyte	NN	NN	_	8	compound	_	_
7	chemotactic	chemotactic	JJ	JJ	_	8	amod	_	_
8	protein-1	protein-1	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MCP-1	mcp-1	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	secretion	secretion	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	surface	surface	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	intercellular	intercellular	JJ	JJ	_	19	amod	_	_
18	adhesion	adhesion	NN	NN	_	19	compound	_	_
19	molecule-1	molecule-1	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ICAM-1	icam-1	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	on	on	IN	IN	_	25	case	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	2	nmod	_	_
26	has	have	VBZ	VBZ	_	28	aux	_	_
27	been	be	VBN	VBN	_	28	auxpass	_	_
28	assessed	assess	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	METHODS	method	NNS	NNS	_	13	dep	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	RESULTS	result	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	13	punct	_	_
5	Monolayers	monolayer	NNS	NNS	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	11	case	_	_
7	human	human	JJ	JJ	_	11	amod	_	_
8	umbilical	umbilical	JJ	JJ	_	11	amod	_	_
9	vein	vein	NN	NN	_	11	compound	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	incubated	incubate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	18	case	_	_
15	nonstimulated	nonstimulated	JJ	JJ	_	18	amod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	ADP-activated	adp-activated	JJ	JJ	_	15	conj	_	_
18	platelets	platelet	NNS	NNS	_	13	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	6	6	CD	CD	_	21	nummod	_	_
21	hours	hour	NNS	NNS	_	13	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	secretion	secretion	NN	NN	_	33	nsubjpass	_	_
25	of	of	IN	IN	_	26	case	_	_
26	MCP-1	mcp-1	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	surface	surface	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	24	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	ICAM-1	icam-1	NN	NN	_	29	nmod	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	determined	determine	VBN	VBN	_	13	conj	_	_
34	by	by	IN	IN	_	35	case	_	_
35	ELISA	elisa	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	flow	flow	NN	NN	_	38	compound	_	_
38	cytometry	cytometry	NN	NN	_	35	conj	_	_
39	,	,	,	,	_	33	punct	_	_
40	respectively	respectively	RB	RB	_	33	advmod	_	_
41	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	dep	_	_
3	presence	presence	NN	NN	_	6	dep	_	_
4	of	of	IN	IN	_	6	case	_	_
5	ADP-activated	adp-activated	JJ	JJ	_	6	amod	_	_
6	platelets	platelet	NNS	NNS	_	17	nmod	_	_
7	,	,	,	,	_	17	punct	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	MCP-1	mcp-1	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	17	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	ICAM-1	icam-1	NN	NN	_	14	compound	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	conj	_	_
15	were	be	VBD	VBD	_	17	auxpass	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	increased	increase	VBN	VBN	_	0	root	_	_
18	compared	compare	VBN	VBN	_	21	case	_	_
19	with	with	IN	IN	_	21	case	_	_
20	nonstimulated	nonstimulated	JJ	JJ	_	21	amod	_	_
21	platelets	platelet	NNS	NNS	_	17	advcl	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	P	p	NN	NN	_	24	dep	_	_
24	&lt;	&lt;	JJR	JJR	_	21	dep	_	_
25	0.02	0.02	CD	CD	_	24	nummod	_	_
26	)	)	-RRB-	-RRB-	_	24	punct	_	_
27	.	.	.	.	_	17	punct	_	_

1	Activation	activation	NN	NN	_	22	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	transcription	transcription	NN	NN	_	7	compound	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor-kappaB	factor-kappab	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	determined	determine	VBN	VBN	_	1	acl	_	_
12	by	by	IN	IN	_	16	case	_	_
13	electrophoretic	electrophoretic	JJ	JJ	_	16	amod	_	_
14	mobility	mobility	NN	NN	_	16	compound	_	_
15	shift	shift	NN	NN	_	16	compound	_	_
16	assay	assay	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	kappaB-dependent	kappab-dependent	JJ	JJ	_	20	amod	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	16	conj	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	enhanced	enhance	VBN	VBN	_	0	root	_	_
23	in	in	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	dep	_	_
25	presence	presence	NN	NN	_	28	dep	_	_
26	of	of	IN	IN	_	28	case	_	_
27	activated	activate	VBN	VBN	_	28	amod	_	_
28	platelets	platelet	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	ADP-activated	adp-activated	JJ	JJ	_	5	amod	_	_
5	platelets	platelet	NNS	NNS	_	6	nsubj	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	MCP-1	mcp-1	NN	NN	_	11	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ICAM-1	icam-1	NN	NN	_	7	conj	_	_
10	promoter-dependent	promoter-dependent	JJ	JJ	_	11	amod	_	_
11	transcription	transcription	NN	NN	_	6	dobj	_	_
12	.	.	.	.	_	6	punct	_	_

1	Liposomal	liposomal	JJ	JJ	_	2	amod	_	_
2	transfection	transfection	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	a	a	DT	DT	_	8	det	_	_
5	double-stranded	double-stranded	JJ	JJ	_	8	amod	_	_
6	kappaB	kappab	NN	NN	_	8	compound	_	_
7	phosphorothioate	phosphorothioate	NN	NN	_	8	compound	_	_
8	oligonucleotide	oligonucleotide	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	8	cc	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	mutated	mutated	JJ	JJ	_	15	amod	_	_
15	form	form	NN	NN	_	8	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	inhibited	inhibit	VBD	VBD	_	0	root	_	_
18	MCP-1	mcp-1	NN	NN	_	19	compound	_	_
19	secretion	secretion	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	surface	surface	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	ICAM-1	icam-1	NN	NN	_	22	nmod	_	_
25	on	on	IN	IN	_	27	case	_	_
26	activated	activate	VBN	VBN	_	27	amod	_	_
27	endothelium	endothelium	NN	NN	_	19	nmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	P	p	NN	NN	_	30	dep	_	_
30	&lt;	&lt;	JJR	JJR	_	27	dep	_	_
31	0.05	0.05	CD	CD	_	30	nummod	_	_
32	)	)	-RRB-	-RRB-	_	30	punct	_	_
33	.	.	.	.	_	17	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	5	det	_	_
4	present	present	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	6	nsubj	_	_
6	indicates	indicate	VBZ	VBZ	_	1	appos	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	activated	activate	VBN	VBN	_	9	amod	_	_
9	platelets	platelet	NNS	NNS	_	10	nsubj	_	_
10	modulate	modulate	VBP	VBP	_	6	ccomp	_	_
11	chemotactic	chemotactic	JJ	JJ	_	20	amod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	MCP-1	mcp-1	NN	NN	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	adhesive	adhesive	JJ	JJ	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ICAM-1	icam-1	NN	NN	_	16	dep	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	properties	property	NNS	NNS	_	10	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	via	via	IN	IN	_	27	case	_	_
25	an	a	DT	DT	_	27	det	_	_
26	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	27	amod	_	_
27	mechanism	mechanism	NN	NN	_	10	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	Platelet-induced	platelet-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	system	system	NN	NN	_	2	nmod	_	_
7	might	might	MD	MD	_	8	aux	_	_
8	contribute	contribute	VB	VB	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	early	early	JJ	JJ	_	12	amod	_	_
11	inflammatory	inflammatory	JJ	JJ	_	12	amod	_	_
12	events	event	NNS	NNS	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	atherogenesis	atherogenesis	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Upregulation	upregulation	NN	NN	_	23	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	interleukin	interleukin	NN	NN	_	1	nmod	_	_
4	6	6	CD	CD	_	3	nummod	_	_
5	and	and	CC	CC	_	3	cc	_	_
6	granulocyte	granulocyte	NN	NN	_	9	compound	_	_
7	colony-stimulating	colony-stimulating	JJ	JJ	_	9	amod	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	3	conj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	1	nmod	_	_
13	CCAAT	ccaat	NN	NN	_	17	compound	_	_
14	enhancer	enhancer	NN	NN	_	17	compound	_	_
15	binding	binding	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	dep	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	C/EBP	c/ebp	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	critical	critical	JJ	JJ	_	0	root	_	_
24	for	for	IN	IN	_	25	case	_	_
25	granulopoiesis	granulopoiesis	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	23	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	2	nsubj	_	_
2	stimulate	stimulate	VBP	VBP	_	0	root	_	_
3	granulopoiesis	granulopoiesis	NN	NN	_	2	dobj	_	_
4	through	through	IN	IN	_	5	case	_	_
5	signaling	signaling	NN	NN	_	2	nmod	_	_
6	via	via	IN	IN	_	7	case	_	_
7	receptors	receptor	NNS	NNS	_	5	nmod	_	_
8	whose	whose	WP$	WP$	_	9	nmod:poss	_	_
9	expression	expression	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	controlled	control	VBN	VBN	_	7	acl:relcl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	lineage-specific	lineage-specific	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Previously	previously	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	granulocyte	granulocyte	NN	NN	_	13	compound	_	_
7	colony-stimulating	colony-stimulating	JJ	JJ	_	13	amod	_	_
8	factor	factor	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	G-CSF	g-csf	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	mRNA	mrna	NN	NN	_	15	nsubj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	undetectable	undetectable	JJ	JJ	_	4	ccomp	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	granulocyte	granulocyte	NN	NN	_	18	compound	_	_
18	maturation	maturation	NN	NN	_	19	nsubj	_	_
19	blocked	block	VBN	VBN	_	15	conj	_	_
20	in	in	IN	IN	_	30	case	_	_
21	CCAAT	ccaat	NN	NN	_	25	compound	_	_
22	enhancer	enhancer	NN	NN	_	25	compound	_	_
23	binding	binding	NN	NN	_	25	compound	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	alpha	alpha	NN	NN	_	29	nmod:npmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	C/EBPalpha	c/ebpalpha	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	-deficient	-deficient	JJ	JJ	_	30	amod	_	_
30	mice	mouse	NNS	NNS	_	19	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenotype	phenotype	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	distinct	distinct	JJ	JJ	_	0	root	_	_
5	from	from	IN	IN	_	6	case	_	_
6	that	that	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	G-CSF	g-csf	NN	NN	_	10	compound	_	_
9	receptor-/-	receptor-/-	JJ	JJ	_	10	amod	_	_
10	mice	mouse	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	suggesting	suggest	VBG	VBG	_	4	xcomp	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	likely	likely	JJ	JJ	_	12	ccomp	_	_
18	to	to	TO	TO	_	21	mark	_	_
19	be	be	VB	VB	_	21	auxpass	_	_
20	adversely	adversely	RB	RB	_	21	advmod	_	_
21	affected	affect	VBN	VBN	_	17	xcomp	_	_
22	by	by	IN	IN	_	23	case	_	_
23	loss	loss	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	C/EBPalpha	c/ebpalpha	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	loss	loss	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	interleukin	interleukin	NN	NN	_	11	compound	_	_
7	6	6	CD	CD	_	11	nummod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	IL-6	il-6	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	receptor	receptor	NN	NN	_	4	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	IL-6-responsive	il-6-responsive	JJ	JJ	_	15	amod	_	_
14	colony-forming	colony-forming	JJ	JJ	_	15	amod	_	_
15	units	unit	NNS	NNS	_	4	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CFU-IL6	cfu-il6	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	in	in	IN	IN	_	21	case	_	_
20	C/EBPalpha-/-	c/ebpalpha-/-	JJ	JJ	_	21	amod	_	_
21	mice	mouse	NNS	NNS	_	4	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	observed	observe	VBN	VBN	_	3	amod	_	_
3	failure	failure	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	granulopoiesis	granulopoiesis	NN	NN	_	3	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	rescued	rescue	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	addition	addition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	soluble	soluble	JJ	JJ	_	15	amod	_	_
14	IL-6	il-6	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IL-6	il-6	NN	NN	_	15	conj	_	_
18	or	or	CC	CC	_	11	cc	_	_
19	by	by	IN	IN	_	21	case	_	_
20	retroviral	retroviral	JJ	JJ	_	21	amod	_	_
21	transduction	transduction	NN	NN	_	11	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	G-CSF	g-csf	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	8	punct	_	_
26	demonstrating	demonstrate	VBG	VBG	_	8	xcomp	_	_
27	that	that	IN	IN	_	34	mark	_	_
28	loss	loss	NN	NN	_	34	nsubj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	both	both	DT	DT	_	28	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	these	these	DT	DT	_	33	det	_	_
33	receptors	receptor	NNS	NNS	_	30	nmod	_	_
34	contributes	contribute	VBZ	VBZ	_	26	ccomp	_	_
35	to	to	TO	TO	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	absolute	absolute	JJ	JJ	_	38	amod	_	_
38	block	block	NN	NN	_	34	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	granulocyte	granulocyte	NN	NN	_	41	compound	_	_
41	maturation	maturation	NN	NN	_	38	nmod	_	_
42	observed	observe	VBN	VBN	_	38	acl	_	_
43	in	in	IN	IN	_	46	case	_	_
44	C/EBPalpha-deficient	c/ebpalpha-deficient	JJ	JJ	_	46	amod	_	_
45	hematopoietic	hematopoietic	JJ	JJ	_	46	amod	_	_
46	cells	cell	NNS	NNS	_	42	nmod	_	_
47	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	these	these	DT	DT	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	other	other	JJ	JJ	_	4	conj	_	_
7	studies	study	NNS	NNS	_	4	dep	_	_
8	suggest	suggest	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	22	mark	_	_
10	additional	additional	JJ	JJ	_	13	amod	_	_
11	C/EBPalpha	c/ebpalpha	NN	NN	_	13	compound	_	_
12	target	target	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	22	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	possibly	possibly	RB	RB	_	18	advmod	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	cytokine	cytokine	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	13	appos	_	_
19	,	,	,	,	_	13	punct	_	_
20	are	be	VBP	VBP	_	22	cop	_	_
21	also	also	RB	RB	_	22	advmod	_	_
22	important	important	JJ	JJ	_	8	ccomp	_	_
23	for	for	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	block	block	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	granulocyte	granulocyte	NN	NN	_	28	compound	_	_
28	differentiation	differentiation	NN	NN	_	25	nmod	_	_
29	observed	observe	VBN	VBN	_	25	acl	_	_
30	in	in	FW	FW	_	31	compound	_	_
31	vivo	vivo	FW	FW	_	29	advmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	C/EBPalpha-deficient	c/ebpalpha-deficient	JJ	JJ	_	34	amod	_	_
34	mice	mouse	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Altered	altered	JJ	JJ	_	4	amod	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	4	amod	_	_
3	specificity	specificity	NN	NN	_	4	compound	_	_
4	mutants	mutant	NNS	NNS	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	EKLF	eklf	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Sp1	sp1	NN	NN	_	6	conj	_	_
9	show	show	VBP	VBP	_	0	root	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	EKLF	eklf	NN	NN	_	14	nsubj	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	an	a	DT	DT	_	14	det	_	_
14	activator	activator	NN	NN	_	9	ccomp	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	beta-globin	beta-globin	NN	NN	_	20	compound	_	_
18	locus	locus	NN	NN	_	20	compound	_	_
19	control	control	NN	NN	_	20	compound	_	_
20	region	region	NN	NN	_	14	nmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	14	advmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	locus	locus	NN	NN	_	4	compound	_	_
3	control	control	NN	NN	_	4	compound	_	_
4	region	region	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	beta-globin	beta-globin	NN	NN	_	8	compound	_	_
8	cluster	cluster	NN	NN	_	4	nmod	_	_
9	contains	contain	VBZ	VBZ	_	0	root	_	_
10	five	five	CD	CD	_	14	nummod	_	_
11	DNase	dnase	NN	NN	_	14	compound	_	_
12	I	i	CD	CD	_	14	nummod	_	_
13	hypersensitive	hypersensitive	JJ	JJ	_	14	amod	_	_
14	sites	site	NNS	NNS	_	9	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	5'HS1-5	5'hs1-5	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	required	require	VBN	VBN	_	14	acl	_	_
19	for	for	IN	IN	_	21	case	_	_
20	locus	locus	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	5'HS3	5'hs3	NN	NN	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	six	six	CD	CD	_	5	nummod	_	_
4	G-rich	g-rich	JJ	JJ	_	5	amod	_	_
5	motifs	motif	NNS	NNS	_	2	dobj	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	essential	essential	JJ	JJ	_	5	acl:relcl	_	_
9	for	for	IN	IN	_	11	case	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Members	member	NNS	NNS	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	family	family	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	characterized	characterize	VBN	VBN	_	5	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	zinc	zinc	NN	NN	_	11	compound	_	_
11	fingers	finger	NNS	NNS	_	7	nmod	_	_
12	highly	highly	RB	RB	_	13	advmod	_	_
13	homologous	homologous	JJ	JJ	_	11	amod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	those	those	DT	DT	_	13	nmod	_	_
16	found	find	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	20	case	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	Sp1	sp1	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	interact	interact	VBP	VBP	_	0	root	_	_
23	with	with	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	motifs	motif	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	22	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	point	point	NN	NN	_	3	compound	_	_
3	mutagenesis	mutagenesis	NN	NN	_	6	nsubj	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	distinguish	distinguish	VB	VB	_	14	advcl	_	_
7	between	between	IN	IN	_	9	case	_	_
8	family	family	NN	NN	_	9	compound	_	_
9	members	member	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	it	it	PRP	PRP	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	known	know	VBN	VBN	_	0	root	_	_
15	which	which	WDT	WDT	_	16	det	_	_
16	protein	protein	NN	NN	_	17	nsubj	_	_
17	activates	activate	VBZ	VBZ	_	14	ccomp	_	_
18	5'HS3	5'hs3	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	function	function	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	such	such	JJ	JJ	_	10	amod	_	_
8	closely	closely	RB	RB	_	9	advmod	_	_
9	related	related	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	5	nmod	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	distinguished	distinguish	VBN	VBN	_	2	ccomp	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	13	advmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	matching	match	VBG	VBG	_	13	advcl	_	_
18	point	point	NN	NN	_	19	compound	_	_
19	mutations	mutation	NNS	NNS	_	17	dobj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	5'HS3	5'hs3	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	amino	amino	NN	NN	_	25	compound	_	_
24	acid	acid	NN	NN	_	25	compound	_	_
25	changes	change	NNS	NNS	_	17	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	zinc	zinc	NN	NN	_	29	compound	_	_
29	fingers	finger	NNS	NNS	_	25	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	Sp1	sp1	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	EKLF	eklf	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	2	punct	_	_

1	Testing	test	VBG	VBG	_	7	csubj	_	_
2	their	they	PRP$	PRP$	_	3	nmod:poss	_	_
3	activity	activity	NN	NN	_	1	dobj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	transgenic	transgenic	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	3	nmod	_	_
7	shows	show	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	EKLF	eklf	NN	NN	_	13	nsubj	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	direct	direct	JJ	JJ	_	13	amod	_	_
13	activator	activator	NN	NN	_	7	ccomp	_	_
14	of	of	IN	IN	_	15	case	_	_
15	5'HS3	5'hs3	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	status	status	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BCL-6	bcl-6	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	syndecan-1	syndecan-1	NN	NN	_	4	conj	_	_
7	identifies	identify	VBZ	VBZ	_	0	root	_	_
8	distinct	distinct	JJ	JJ	_	10	amod	_	_
9	histogenetic	histogenetic	JJ	JJ	_	10	amod	_	_
10	subtypes	subtype	NNS	NNS	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	Hodgkin	hodgkin	NN	NN	_	14	nmod:poss	_	_
13	's	's	POS	POS	_	12	case	_	_
14	disease	disease	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	tumor	tumor	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	most	most	JJS	JJS	_	6	amod	_	_
6	cases	case	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	Hodgkin	hodgkin	NN	NN	_	10	nmod:poss	_	_
9	's	's	POS	POS	_	8	case	_	_
10	disease	disease	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	HD	hd	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	have	have	VBP	VBP	_	17	aux	_	_
15	been	be	VBN	VBN	_	17	auxpass	_	_
16	recently	recently	RB	RB	_	17	advmod	_	_
17	recognized	recognize	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	originate	originate	VB	VB	_	17	xcomp	_	_
20	from	from	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	B-cell	b-cell	NN	NN	_	23	compound	_	_
23	lineage	lineage	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	17	punct	_	_
25	but	but	CC	CC	_	17	cc	_	_
26	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
27	precise	precise	JJ	JJ	_	29	amod	_	_
28	differentiation	differentiation	NN	NN	_	29	compound	_	_
29	stage	stage	NN	NN	_	33	nsubjpass	_	_
30	is	be	VBZ	VBZ	_	33	auxpass	_	_
31	not	not	RB	RB	_	33	neg	_	_
32	fully	fully	RB	RB	_	33	advmod	_	_
33	clarified	clarify	VBN	VBN	_	17	conj	_	_
34	.	.	.	.	_	17	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	reported	report	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	14	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	histogenesis	histogenesis	NN	NN	_	14	nsubjpass	_	_
9	of	of	IN	IN	_	11	case	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	lymphomas	lymphoma	NNS	NNS	_	8	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	assessed	assess	VBN	VBN	_	5	ccomp	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	monitoring	monitor	VBG	VBG	_	14	advcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	expression	expression	NN	NN	_	19	compound	_	_
19	pattern	pattern	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	BCL-6	bcl-6	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	21	appos	_	_
26	expressed	express	VBN	VBN	_	25	acl	_	_
27	in	in	IN	IN	_	34	case	_	_
28	germinal	germinal	JJ	JJ	_	34	amod	_	_
29	center	center	NN	NN	_	34	compound	_	_
30	(	(	-LRB-	-LRB-	_	34	punct	_	_
31	GC	gc	NN	NN	_	34	compound	_	_
32	)	)	-RRB-	-RRB-	_	34	punct	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	26	nmod	_	_
35	,	,	,	,	_	21	punct	_	_
36	and	and	CC	CC	_	21	cc	_	_
37	CD138/syndecan-1	cd138/syndecan-1	NN	NN	_	21	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	syn-1	syn-1	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	,	,	,	,	_	37	punct	_	_
42	a	a	DT	DT	_	43	det	_	_
43	proteoglycan	proteoglycan	NN	NN	_	37	appos	_	_
44	associated	associate	VBN	VBN	_	43	acl	_	_
45	with	with	IN	IN	_	50	case	_	_
46	post-GC	post-gc	JJ	JJ	_	50	amod	_	_
47	,	,	,	,	_	46	punct	_	_
48	terminal	terminal	JJ	JJ	_	46	dep	_	_
49	B-cell	b-cell	NN	NN	_	50	compound	_	_
50	differentiation	differentiation	NN	NN	_	44	nmod	_	_
51	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	applied	apply	VBN	VBN	_	0	root	_	_
8	these	these	DT	DT	_	10	det	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	markers	marker	NNS	NNS	_	7	dobj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	study	study	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HD	hd	NN	NN	_	16	compound	_	_
16	histogenesis	histogenesis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	in	in	IN	IN	_	9	case	_	_
6	nodular	nodular	JJ	JJ	_	9	amod	_	_
7	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
8	predominance	predominance	NN	NN	_	9	compound	_	_
9	HD	hd	NN	NN	_	16	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NLPHD	nlphd	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	tumor	tumor	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	16	nsubj	_	_
15	consistently	consistently	RB	RB	_	16	advmod	_	_
16	display	display	VBP	VBP	_	3	ccomp	_	_
17	the	the	DT	DT	_	19	det	_	_
18	BCL-6(+)/syn-1(-)	bcl-6(+)/syn-1(-)	JJ	JJ	_	19	amod	_	_
19	phenotype	phenotype	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	16	punct	_	_
21	indicating	indicate	VBG	VBG	_	16	advcl	_	_
22	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
23	derivation	derivation	NN	NN	_	21	dobj	_	_
24	from	from	IN	IN	_	27	case	_	_
25	GC	gc	NN	NN	_	27	compound	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Conversely	conversely	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	classic	classic	JJ	JJ	_	4	amod	_	_
4	HD	hd	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CHD	chd	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	heterogeneous	heterogeneous	JJ	JJ	_	0	root	_	_
10	because	because	IN	IN	_	19	mark	_	_
11	the	the	DT	DT	_	13	det	_	_
12	tumor	tumor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	19	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	fraction	fraction	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CHD	chd	NN	NN	_	16	nmod	_	_
19	display	display	VBP	VBP	_	9	advcl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	BCL-6(-)/syn-1(+)	bcl-6(-)/syn-1(+)	JJ	JJ	_	22	amod	_	_
22	phenotype	phenotype	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	post-GC	post-gc	JJ	JJ	_	25	amod	_	_
25	B-cells	b-cell	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	9	punct	_	_
27	whereas	whereas	IN	IN	_	9	dep	_	_
28	another	another	DT	DT	_	29	det	_	_
29	fraction	fraction	NN	NN	_	33	nsubjpass	_	_
30	of	of	IN	IN	_	31	case	_	_
31	CHD	chd	NN	NN	_	29	nmod	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	constituted	constitute	VBN	VBN	_	9	parataxis	_	_
34	by	by	IN	IN	_	36	case	_	_
35	a	a	DT	DT	_	36	det	_	_
36	mixture	mixture	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	tumor	tumor	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	reflecting	reflect	VBG	VBG	_	33	xcomp	_	_
41	the	the	DT	DT	_	51	det	_	_
42	GC	gc	NN	NN	_	51	compound	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	BCL-6(+)/syn-1(-)	bcl-6(+)/syn-1(-)	JJ	JJ	_	42	dep	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	or	or	CC	CC	_	42	cc	_	_
47	post-GC	post-gc	JJ	JJ	_	42	conj	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	BCL-6(-)/syn-1(+)	bcl-6(-)/syn-1(+)	JJ	JJ	_	47	dep	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	phenotypes	phenotype	NNS	NNS	_	40	dobj	_	_
52	.	.	.	.	_	9	punct	_	_

1	BCL-6(-)/syn-1(+)	bcl-6(-)/syn-1(+)	JJ	JJ	_	3	amod	_	_
2	tumor	tumor	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CHD	chd	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	mostly	mostly	RB	RB	_	8	advmod	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	surrounded	surround	VBN	VBN	_	8	dep	_	_
10	by	by	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	expressing	express	VBG	VBG	_	12	acl	_	_
14	CD40L	cd40l	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	8	punct	_	_
16	consistent	consistent	JJ	JJ	_	8	xcomp	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	observation	observation	NN	NN	_	16	nmod	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	CD40	cd40	NN	NN	_	22	compound	_	_
22	signaling	signaling	NN	NN	_	23	nsubj	_	_
23	downregulates	downregulate	VBZ	VBZ	_	19	ccomp	_	_
24	BCL-6	bcl-6	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	tumor	tumor	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	10	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NLPHD	nlphd	NN	NN	_	6	nmod	_	_
9	uniformly	uniformly	RB	RB	_	10	advmod	_	_
10	display	display	VBP	VBP	_	3	ccomp	_	_
11	a	a	DT	DT	_	14	det	_	_
12	GC	gc	NN	NN	_	14	compound	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	phenotype	phenotype	NN	NN	_	10	dobj	_	_
15	,	,	,	,	_	10	punct	_	_
16	whereas	whereas	IN	IN	_	10	dep	_	_
17	the	the	DT	DT	_	18	det	_	_
18	phenotype	phenotype	NN	NN	_	24	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	tumor	tumor	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	CHD	chd	NN	NN	_	21	nmod	_	_
24	appears	appear	VBZ	VBZ	_	10	parataxis	_	_
25	to	to	TO	TO	_	27	mark	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	modulated	modulate	VBN	VBN	_	24	xcomp	_	_
28	by	by	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	surrounding	surrounding	JJ	JJ	_	32	amod	_	_
31	cellular	cellular	JJ	JJ	_	32	amod	_	_
32	background	background	NN	NN	_	27	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	particularly	particularly	RB	RB	_	38	advmod	_	_
35	CD40L+	cd40l+	JJ	JJ	_	38	amod	_	_
36	reactive	reactive	JJ	JJ	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	appos	_	_
39	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	novel	novel	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	19	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	coding	code	VBG	VBG	_	7	amod	_	_
7	sequence	sequence	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	FY*B	fy*b	NN	NN	_	11	compound	_	_
11	allele	allele	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	Duffy	duffy	NN	NN	_	17	compound	_	_
15	chemokine	chemokine	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	11	nmod	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	associated	associate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	24	case	_	_
21	an	a	DT	DT	_	24	det	_	_
22	altered	altered	JJ	JJ	_	24	amod	_	_
23	erythrocyte	erythrocyte	NN	NN	_	24	compound	_	_
24	phenotype	phenotype	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Duffy	duffy	NN	NN	_	5	compound	_	_
3	blood	blood	NN	NN	_	5	compound	_	_
4	group	group	NN	NN	_	5	compound	_	_
5	system	system	NN	NN	_	11	nsubj	_	_
6	is	be	VBZ	VBZ	_	11	cop	_	_
7	of	of	IN	IN	_	11	case	_	_
8	clinical	clinical	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	biological	biological	JJ	JJ	_	8	conj	_	_
11	significance	significance	NN	NN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Antibodies	antibody	NNS	NNS	_	6	nsubj	_	_
2	to	to	TO	TO	_	4	case	_	_
3	Duffy	duffy	NN	NN	_	4	compound	_	_
4	antigens	antigen	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	responsible	responsible	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	some	some	DT	DT	_	9	det	_	_
9	cases	case	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transfusion	transfusion	NN	NN	_	12	compound	_	_
12	incompatibility	incompatibility	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	newborn	newborn	JJ	JJ	_	16	amod	_	_
15	hemolytic	hemolytic	JJ	JJ	_	16	amod	_	_
16	disease	disease	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Duffy	duffy	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	receptor	receptor	NN	NN	_	0	root	_	_
7	for	for	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	Plasmodium	plasmodium	NN	NN	_	12	compound	_	_
10	vivax	vivax	NN	NN	_	12	compound	_	_
11	erythrocyte-binding	erythrocyte-binding	JJ	JJ	_	12	amod	_	_
12	protein	protein	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	also	also	RB	RB	_	17	advmod	_	_
16	a	a	DT	DT	_	17	det	_	_
17	receptor	receptor	NN	NN	_	6	conj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	various	various	JJ	JJ	_	20	amod	_	_
20	chemokines	chemokine	NNS	NNS	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	17	punct	_	_
22	thus	thus	RB	RB	_	23	advmod	_	_
23	renamed	rename	VBN	VBN	_	17	dep	_	_
24	Duffy	duffy	NN	NN	_	28	compound	_	_
25	Antigen	antigen	NN	NN	_	28	compound	_	_
26	Receptor	receptor	NN	NN	_	28	compound	_	_
27	for	for	IN	IN	_	28	amod	_	_
28	Chemokines	chemokine	NNS	NNS	_	23	xcomp	_	_
29	-LSB-	-lsb-	-LRB-	-LRB-	_	30	punct	_	_
30	DARC	darc	NN	NN	_	28	appos	_	_
31	-RSB-	-rsb-	-RRB-	-RRB-	_	30	punct	_	_
32	)	)	-RRB-	-RRB-	_	17	punct	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	two	two	CD	CD	_	5	nummod	_	_
3	Duffy	duffy	NN	NN	_	5	compound	_	_
4	polymorphic	polymorphic	JJ	JJ	_	5	amod	_	_
5	antigens	antigen	NNS	NNS	_	21	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	Fya	fya	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Fyb	fyb	NN	NN	_	7	conj	_	_
10	(	(	-LRB-	-LRB-	_	7	punct	_	_
11	coded	code	VBN	VBN	_	7	acl	_	_
12	by	by	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	FY*A	fy*a	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	FY*B	fy*b	NN	NN	_	14	conj	_	_
17	alleles	allele	NNS	NNS	_	11	nmod	_	_
18	)	)	-RRB-	-RRB-	_	7	punct	_	_
19	,	,	,	,	_	5	punct	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	present	present	JJ	JJ	_	0	root	_	_
22	on	on	IN	IN	_	24	case	_	_
23	erythrocyte	erythrocyte	NN	NN	_	24	compound	_	_
24	membranes	membrane	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Fy(a-b-)	fy(a-b-)	NN	NN	_	3	compound	_	_
3	phenotype	phenotype	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	the	the	DT	DT	_	7	det	_	_
6	predominant	predominant	JJ	JJ	_	7	amod	_	_
7	one	one	CD	CD	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	populations	population	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	black	black	JJ	JJ	_	12	amod	_	_
12	people	people	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	also	also	RB	RB	_	7	advmod	_	_
15	occurs	occur	VBZ	VBZ	_	7	dep	_	_
16	in	in	IN	IN	_	18	case	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	populations	population	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	24	case	_	_
21	some	some	DT	DT	_	24	det	_	_
22	non-Ashkenazi	non-ashkenazi	JJ	JJ	_	23	amod	_	_
23	Jewish	jewish	JJ	JJ	_	24	amod	_	_
24	groups	group	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Fy(a-b-)	fy(a-b-)	NN	NN	_	3	compound	_	_
3	phenotype	phenotype	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	associated	associate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	mutation	mutation	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	FY*B	fy*b	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	GATA	gata	NN	NN	_	17	compound	_	_
17	box	box	NN	NN	_	13	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	abolishes	abolish	VBZ	VBZ	_	9	acl:relcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	erythrocyte	erythrocyte	NN	NN	_	25	compound	_	_
24	Duffy	duffy	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	mutation	mutation	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	present	present	JJ	JJ	_	6	amod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	FY*B	fy*b	NN	NN	_	13	compound	_	_
12	coding	code	VBG	VBG	_	13	amod	_	_
13	sequence	sequence	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	271C	271c	NN	NN	_	17	compound	_	_
16	--&gt;	--&gt;	TO	TO	_	17	dep	_	_
17	T	t	NN	NN	_	13	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	6	punct	_	_
20	that	that	WDT	WDT	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	6	acl:relcl	_	_
23	with	with	IN	IN	_	26	case	_	_
24	some	some	DT	DT	_	26	det	_	_
25	Fy(b-)	fy(b-)	NN	NN	_	26	compound	_	_
26	phenotypes	phenotype	NNS	NNS	_	22	nmod	_	_
27	among	among	IN	IN	_	29	case	_	_
28	non-Ashkenazi	non-ashkenazi	JJ	JJ	_	29	amod	_	_
29	Jews	jew	NNS	NNS	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	among	among	IN	IN	_	33	case	_	_
32	Brazilian	brazilian	JJ	JJ	_	33	amod	_	_
33	blacks	black	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mutation	mutation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Fy(b-)	fy(b-)	NN	NN	_	7	compound	_	_
7	individuals	individual	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	who	who	WP	WP	_	10	nsubj	_	_
10	have	have	VBP	VBP	_	7	acl:relcl	_	_
11	wild-type	wild-type	JJ	JJ	_	13	amod	_	_
12	FY*B	fy*b	NN	NN	_	13	compound	_	_
13	GATA	gata	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	carry	carry	VBP	VBP	_	10	conj	_	_
16	the	the	DT	DT	_	22	det	_	_
17	previously	previously	RB	RB	_	18	advmod	_	_
18	described	describe	VBN	VBN	_	22	amod	_	_
19	304G	304g	NN	NN	_	22	compound	_	_
20	--&gt;	--&gt;	TO	TO	_	22	dep	_	_
21	A	a	NN	NN	_	22	compound	_	_
22	substitution	substitution	NN	NN	_	15	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	271C	271c	NN	NN	_	4	compound	_	_
3	--&gt;	--&gt;	TO	TO	_	4	dep	_	_
4	T	t	NN	NN	_	11	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	304G	304g	NN	NN	_	8	compound	_	_
7	--&gt;	--&gt;	TO	TO	_	8	dep	_	_
8	A	a	NN	NN	_	4	conj	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	18	case	_	_
13	restriction	restriction	NN	NN	_	18	compound	_	_
14	enzyme-generated	enzyme-generated	JJ	JJ	_	18	amod	_	_
15	restriction	restriction	NN	NN	_	18	compound	_	_
16	fragment	fragment	NN	NN	_	18	compound	_	_
17	length	length	NN	NN	_	18	compound	_	_
18	polymorphisms	polymorphism	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	271C	271c	NN	NN	_	5	compound	_	_
3	--&gt;	--&gt;	TO	TO	_	5	dep	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	substitution	substitution	NN	NN	_	6	nsubj	_	_
6	represents	represent	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	considerable	considerable	JJ	JJ	_	9	amod	_	_
9	change	change	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	chemical	chemical	JJ	JJ	_	12	amod	_	_
12	nature	nature	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	Arg91	arg91	NN	NN	_	16	compound	_	_
15	--&gt;	--&gt;	TO	TO	_	16	dep	_	_
16	Cys	cys	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	9	punct	_	_
19	one	one	CD	CD	_	9	appos	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	affect	affect	VB	VB	_	19	acl:relcl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	antigenic	antigenic	JJ	JJ	_	25	amod	_	_
25	determinants	determinant	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	DARC	darc	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	22	punct	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	thus	thus	RB	RB	_	22	advmod	_	_
31	be	be	VB	VB	_	34	cop	_	_
32	of	of	IN	IN	_	34	case	_	_
33	clinical	clinical	JJ	JJ	_	34	amod	_	_
34	significance	significance	NN	NN	_	22	dep	_	_
35	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mutation	mutation	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	implications	implication	NNS	NNS	_	4	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	some	some	DT	DT	_	9	det	_	_
8	physiological	physiological	JJ	JJ	_	9	amod	_	_
9	roles	role	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	DARC	darc	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	be	be	VB	VB	_	15	cop	_	_
14	of	of	IN	IN	_	15	case	_	_
15	interest	interest	NN	NN	_	4	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	malaria	malaria	NN	NN	_	18	compound	_	_
18	research	research	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	21	case	_	_
21	studies	study	NNS	NNS	_	18	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	population	population	NN	NN	_	24	compound	_	_
24	genetics	genetics	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	-13	-13	CD	CD	_	1	conj	_	_
4	induce	induce	VBP	VBP	_	0	root	_	_
5	upregulation	upregulation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	murine	murine	JJ	JJ	_	11	amod	_	_
9	macrophage	macrophage	NN	NN	_	11	compound	_	_
10	12/15-lipoxygenase	12/15-lipoxygenase	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	5	nmod	_	_
12	:	:	:	:	_	4	punct	_	_
13	evidence	evidence	NN	NN	_	4	dep	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	involvement	involvement	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	STAT6	stat6	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	When	when	WRB	WRB	_	8	advmod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	8	nsubjpass	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	alveolar	alveolar	JJ	JJ	_	6	amod	_	_
6	macrophages	macrophage	NNS	NNS	_	3	conj	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	cultured	culture	VBN	VBN	_	28	advcl	_	_
9	in	in	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	dep	_	_
11	presence	presence	NN	NN	_	15	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	interleukin	interleukin	NN	NN	_	15	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL	il	NN	NN	_	8	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-4	-4	CD	CD	_	15	nummod	_	_
18	or	or	CC	CC	_	15	cc	_	_
19	IL-13	il-13	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	28	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	28	nsubjpass	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	reticulocyte-type	reticulocyte-type	JJ	JJ	_	26	amod	_	_
26	15-lipoxygenase	15-lipoxygenase	NN	NN	_	22	nmod	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	induced	induce	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	mice	mouse	NNS	NNS	_	7	nmod	_	_
3	a	a	DT	DT	_	4	det	_	_
4	15-lipoxygenase	15-lipoxygenase	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	expressed	express	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	7	cc	_	_
10	a	a	DT	DT	_	12	det	_	_
11	leukocyte-type	leukocyte-type	NN	NN	_	12	compound	_	_
12	12-lipoxygenase	12-lipoxygenase	NN	NN	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	present	present	JJ	JJ	_	7	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	peritoneal	peritoneal	JJ	JJ	_	17	amod	_	_
17	macrophages	macrophage	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	17	advcl	_	_
3	whether	whether	IN	IN	_	7	mark	_	_
4	both	both	CC	CC	_	6	dep	_	_
5	lipoxygenase	lipoxygenase	NN	NN	_	6	compound	_	_
6	isoforms	isoform	NNS	NNS	_	7	nsubj	_	_
7	exhibit	exhibit	VBP	VBP	_	2	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	similar	similar	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	7	dobj	_	_
12	toward	toward	IN	IN	_	14	case	_	_
13	cytokine	cytokine	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	studied	study	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	leukocyte-type	leukocyte-type	NN	NN	_	23	compound	_	_
23	12-lipoxygenase	12-lipoxygenase	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	murine	murine	JJ	JJ	_	27	amod	_	_
26	peritoneal	peritoneal	JJ	JJ	_	27	amod	_	_
27	macrophages	macrophage	NNS	NNS	_	23	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	interleukins	interleukin	NNS	NNS	_	19	nmod	_	_
30	and	and	CC	CC	_	17	cc	_	_
31	found	find	VBD	VBD	_	17	conj	_	_
32	that	that	IN	IN	_	39	mark	_	_
33	the	the	DT	DT	_	34	det	_	_
34	activity	activity	NN	NN	_	39	nsubjpass	_	_
35	of	of	IN	IN	_	37	case	_	_
36	this	this	DT	DT	_	37	det	_	_
37	enzyme	enzyme	NN	NN	_	34	nmod	_	_
38	is	be	VBZ	VBZ	_	39	auxpass	_	_
39	upregulated	upregulate	VBN	VBN	_	31	ccomp	_	_
40	in	in	IN	IN	_	43	case	_	_
41	a	a	DT	DT	_	43	det	_	_
42	dose-dependent	dose-dependent	JJ	JJ	_	43	amod	_	_
43	manner	manner	NN	NN	_	39	nmod	_	_
44	when	when	WRB	WRB	_	48	advmod	_	_
45	the	the	DT	DT	_	46	det	_	_
46	cells	cell	NNS	NNS	_	48	nsubjpass	_	_
47	were	be	VBD	VBD	_	48	auxpass	_	_
48	cultured	culture	VBN	VBN	_	39	advcl	_	_
49	in	in	IN	IN	_	54	case	_	_
50	the	the	DT	DT	_	54	dep	_	_
51	presence	presence	NN	NN	_	54	dep	_	_
52	of	of	IN	IN	_	54	case	_	_
53	the	the	DT	DT	_	54	det	_	_
54	IL-4	il-4	NN	NN	_	48	nmod	_	_
55	or	or	CC	CC	_	54	cc	_	_
56	IL-13	il-13	NN	NN	_	54	conj	_	_
57	but	but	CC	CC	_	58	cc	_	_
58	not	not	RB	RB	_	54	cc	_	_
59	by	by	IN	IN	_	60	case	_	_
60	IL-10	il-10	NN	NN	_	54	conj	_	_
61	.	.	.	.	_	17	punct	_	_

1	When	when	WRB	WRB	_	12	advmod	_	_
2	peripheral	peripheral	JJ	JJ	_	4	amod	_	_
3	murine	murine	JJ	JJ	_	4	amod	_	_
4	monocytes	monocyte	NNS	NNS	_	12	nsubjpass	_	_
5	that	that	WDT	WDT	_	8	nsubj	_	_
6	do	do	VBP	VBP	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	express	express	VB	VB	_	4	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	lipoxygenase	lipoxygenase	NN	NN	_	8	dobj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	treated	treat	VBN	VBN	_	20	advcl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	IL-4	il-4	NN	NN	_	12	nmod	_	_
15	expression	expression	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	12/15-lipoxygenase	12/15-lipoxygenase	NN	NN	_	18	compound	_	_
18	mRNA	mrna	NN	NN	_	15	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	induced	induce	VBN	VBN	_	0	root	_	_
21	,	,	,	,	_	20	punct	_	_
22	suggesting	suggest	VBG	VBG	_	20	xcomp	_	_
23	pretranslational	pretranslational	JJ	JJ	_	25	amod	_	_
24	control	control	NN	NN	_	25	compound	_	_
25	mechanisms	mechanism	NNS	NNS	_	22	dobj	_	_
26	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	no	no	DT	DT	_	5	neg	_	_
5	upregulation	upregulation	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	lipoxygenase	lipoxygenase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	when	when	WRB	WRB	_	16	advmod	_	_
13	the	the	DT	DT	_	14	det	_	_
14	macrophages	macrophage	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	prepared	prepare	VBN	VBN	_	11	advcl	_	_
17	from	from	IN	IN	_	20	case	_	_
18	homozygous	homozygous	JJ	JJ	_	20	amod	_	_
19	STAT6-deficient	stat6-deficient	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Peritoneal	peritoneal	JJ	JJ	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transgenic	transgenic	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	2	nmod	_	_
6	that	that	WDT	WDT	_	8	nsubj	_	_
7	systemically	systemically	RB	RB	_	8	advmod	_	_
8	overexpress	overexpress	VBP	VBP	_	2	acl:relcl	_	_
9	IL-4	il-4	NN	NN	_	8	dobj	_	_
10	exhibited	exhibit	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	17	det	_	_
12	threefold	threefold	RB	RB	_	15	advmod	_	_
13	to	to	TO	TO	_	12	dep	_	_
14	fourfold	fourfold	RB	RB	_	12	advmod	_	_
15	higher	higher	JJR	JJR	_	17	amod	_	_
16	12-lipoxygenase	12-lipoxygenase	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	10	dobj	_	_
18	than	than	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	prepared	prepare	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	control	control	JJ	JJ	_	23	amod	_	_
23	animals	animal	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	similar	similar	JJ	JJ	_	3	amod	_	_
3	upregulation	upregulation	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	12-lipoxygenase	12-lipoxygenase	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	heart	heart	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	spleen	spleen	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	lung	lung	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	transgenic	transgenic	JJ	JJ	_	19	amod	_	_
19	animals	animal	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	strong	strong	JJ	JJ	_	5	amod	_	_
5	induction	induction	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	enzyme	enzyme	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	red	red	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	during	during	IN	IN	_	16	case	_	_
15	experimental	experimental	JJ	JJ	_	16	amod	_	_
16	anemia	anemia	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	mice	mouse	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	presented	present	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	17	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	12-lipoxygenase	12-lipoxygenase	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	17	nsubjpass	_	_
13	of	of	IN	IN	_	15	case	_	_
14	murine	murine	JJ	JJ	_	15	amod	_	_
15	macrophages	macrophage	NNS	NNS	_	12	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	upregulated	upregulate	VBN	VBN	_	5	ccomp	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	20	advmod	_	_
20	and	and	CC	CC	_	17	advmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	20	advmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	IL-4	il-4	NN	NN	_	17	nmod	_	_
25	and/or	and/or	CC	CC	_	24	cc	_	_
26	IL-13	il-13	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	17	punct	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	2	2	LS	LS	_	33	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	this	this	DT	DT	_	32	det	_	_
32	upregulation	upregulation	NN	NN	_	33	nsubj	_	_
33	requires	require	VBZ	VBZ	_	17	ccomp	_	_
34	expression	expression	NN	NN	_	33	dobj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	transcription	transcription	NN	NN	_	39	compound	_	_
38	factor	factor	NN	NN	_	39	compound	_	_
39	STAT6	stat6	NN	NN	_	34	nmod	_	_
40	,	,	,	,	_	17	punct	_	_
41	and	and	CC	CC	_	17	cc	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	3	3	LS	LS	_	51	dep	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	the	the	DT	DT	_	47	det	_	_
46	constitutive	constitutive	JJ	JJ	_	47	amod	_	_
47	expression	expression	NN	NN	_	51	nsubj	_	_
48	of	of	IN	IN	_	50	case	_	_
49	the	the	DT	DT	_	50	det	_	_
50	enzyme	enzyme	NN	NN	_	47	nmod	_	_
51	appears	appear	VBZ	VBZ	_	17	conj	_	_
52	to	to	TO	TO	_	55	mark	_	_
53	be	be	VB	VB	_	55	cop	_	_
54	STAT6	stat6	NN	NN	_	55	nmod:npmod	_	_
55	independent	independent	JJ	JJ	_	51	xcomp	_	_
56	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytokine-dependent	cytokine-dependent	JJ	JJ	_	3	amod	_	_
3	upregulation	upregulation	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	murine	murine	JJ	JJ	_	8	amod	_	_
7	macrophage	macrophage	NN	NN	_	8	compound	_	_
8	12-lipoxygenase	12-lipoxygenase	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
11	induction	induction	NN	NN	_	8	conj	_	_
12	during	during	IN	IN	_	14	case	_	_
13	experimental	experimental	JJ	JJ	_	14	amod	_	_
14	anemia	anemia	NN	NN	_	11	nmod	_	_
15	suggests	suggest	VBZ	VBZ	_	0	root	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	close	close	JJ	JJ	_	18	amod	_	_
18	relatedness	relatedness	NN	NN	_	15	dobj	_	_
19	with	with	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	reticulocyte-type	reticulocyte-type	NN	NN	_	23	compound	_	_
23	15-lipoxygenase	15-lipoxygenase	NN	NN	_	18	nmod	_	_
24	despite	despite	IN	IN	_	26	case	_	_
25	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
26	differences	difference	NNS	NNS	_	15	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	positional	positional	JJ	JJ	_	30	amod	_	_
30	specificity	specificity	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	arachidonic	arachidonic	JJ	JJ	_	34	amod	_	_
33	acid	acid	NN	NN	_	34	compound	_	_
34	oxygenation	oxygenation	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	4	nsubj	_	_
2	only	only	RB	RB	_	3	advmod	_	_
3	partially	partially	RB	RB	_	4	advmod	_	_
4	mediates	mediate	VBZ	VBZ	_	0	root	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
6	virus	virus	NN	NN	_	11	compound	_	_
7	latent	latent	JJ	JJ	_	11	amod	_	_
8	membrane	membrane	NN	NN	_	11	compound	_	_
9	protein	protein	NN	NN	_	11	compound	_	_
10	1	1	CD	CD	_	11	nummod	_	_
11	activation	activation	NN	NN	_	4	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	latent	latent	JJ	JJ	_	4	amod	_	_
3	membrane	membrane	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	16	nsubjpass	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LMP1	lmp1	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	11	case	_	_
10	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
11	virus	virus	NN	NN	_	4	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	EBV	ebv	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	required	require	VBN	VBN	_	0	root	_	_
17	for	for	IN	IN	_	19	case	_	_
18	EBV-induced	ebv-induced	JJ	JJ	_	19	amod	_	_
19	immortalization	immortalization	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	causes	cause	VBZ	VBZ	_	16	conj	_	_
26	tumorigenic	tumorigenic	JJ	JJ	_	27	amod	_	_
27	transformation	transformation	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	LMP1	lmp1	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	phenotypic	phenotypic	JJ	JJ	_	5	amod	_	_
5	changes	change	NNS	NNS	_	3	dobj	_	_
6	resembling	resemble	VBG	VBG	_	5	acl	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	xcomp	_	_
10	,	,	,	,	_	5	punct	_	_
11	such	such	JJ	JJ	_	15	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	size	size	NN	NN	_	15	compound	_	_
15	increase	increase	NN	NN	_	5	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	up-regulation	up-regulation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	cell	cell	NN	NN	_	22	compound	_	_
20	surface	surface	NN	NN	_	22	compound	_	_
21	activation	activation	NN	NN	_	22	compound	_	_
22	markers	marker	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	LMP1	lmp1	NN	NN	_	2	nsubj	_	_
2	contains	contain	VBZ	VBZ	_	0	root	_	_
3	two	two	CD	CD	_	4	nummod	_	_
4	domains	domain	NNS	NNS	_	2	dobj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	activate	activate	VBP	VBP	_	4	acl:relcl	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	6	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	one	one	CD	CD	_	4	appos	_	_
13	through	through	IN	IN	_	14	case	_	_
14	interactions	interaction	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	TRAF	traf	NN	NN	_	17	compound	_	_
17	proteins	protein	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	other	other	JJ	JJ	_	12	conj	_	_
21	with	with	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	TRADD	tradd	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	investigate	investigate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	importance	importance	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	up-regulation	up-regulation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	B	b	NN	NN	_	23	compound	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	activation	activation	NN	NN	_	23	compound	_	_
23	markers	marker	NNS	NNS	_	17	nmod	_	_
24	ICAM-1	icam-1	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	CD71	cd71	NN	NN	_	24	conj	_	_
27	by	by	IN	IN	_	28	case	_	_
28	LMP1	lmp1	NN	NN	_	17	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	expression	expression	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	LMP1	lmp1	NN	NN	_	5	nmod	_	_
8	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	from	from	IN	IN	_	14	case	_	_
11	p50/p65-	p50/p65-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	c-Rel-responsive	c-rel-responsive	JJ	JJ	_	11	conj	_	_
14	promoters	promoter	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	this	this	DT	DT	_	19	det	_	_
19	activity	activity	NN	NN	_	23	nsubjpass	_	_
20	can	can	MD	MD	_	23	aux	_	_
21	be	be	VB	VB	_	23	auxpass	_	_
22	completely	completely	RB	RB	_	23	advmod	_	_
23	inhibited	inhibit	VBN	VBN	_	8	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	expression	expression	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	a	a	DT	DT	_	31	det	_	_
28	dominant	dominant	JJ	JJ	_	31	amod	_	_
29	inhibitory	inhibitory	JJ	JJ	_	31	amod	_	_
30	IkappaB	ikappab	NN	NN	_	31	compound	_	_
31	mutant	mutant	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	ICAM-1	icam-1	NN	NN	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CD71	cd71	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	6	auxpass	_	_
5	nevertheless	nevertheless	RB	RB	_	6	advmod	_	_
6	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	LMP1	lmp1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	8	conj	_	_
16	expressing	express	VBG	VBG	_	15	acl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	dominant	dominant	JJ	JJ	_	19	amod	_	_
19	IkappaB	ikappab	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	LMP1-induced	lmp1-induced	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	size	size	NN	NN	_	6	compound	_	_
6	increase	increase	NN	NN	_	12	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	unaffected	unaffect	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	IkappaB	ikappab	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	even	even	RB	RB	_	6	advmod	_	_
6	when	when	WRB	WRB	_	9	advmod	_	_
7	LMP1	lmp1	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	unable	unable	JJ	JJ	_	17	advcl	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	activate	activate	VB	VB	_	9	xcomp	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	17	punct	_	_
14	it	it	PRP	PRP	_	17	nsubj	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	still	still	RB	RB	_	17	advmod	_	_
17	capable	capable	JJ	JJ	_	3	ccomp	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	inducing	induce	VBG	VBG	_	17	advcl	_	_
20	certain	certain	JJ	JJ	_	21	amod	_	_
21	characteristics	characteristic	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	B	b	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	strongly	strongly	RB	RB	_	28	advmod	_	_
28	suggesting	suggest	VBG	VBG	_	17	xcomp	_	_
29	that	that	IN	IN	_	33	mark	_	_
30	LMP1	lmp1	NN	NN	_	33	nsubj	_	_
31	can	can	MD	MD	_	33	aux	_	_
32	also	also	RB	RB	_	33	advmod	_	_
33	activate	activate	VB	VB	_	28	ccomp	_	_
34	cells	cell	NNS	NNS	_	33	dobj	_	_
35	independently	independently	RB	RB	_	33	advmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	NF-kappaB	nf-kappab	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	distinct	distinct	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	neutrophils	neutrophil	NNS	NNS	_	5	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	bacterial	bacterial	JJ	JJ	_	10	amod	_	_
10	LPS	lps	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	interferon-gamma	interferon-gamma	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	GM-CSF	gm-csf	NN	NN	_	10	conj	_	_
16	and	and	CC	CC	_	1	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	necessity	necessity	NN	NN	_	1	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	overcome	overcome	VB	VB	_	18	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	action	action	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	endogenous	endogenous	JJ	JJ	_	25	amod	_	_
25	proteases	protease	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	neutrophils	neutrophil	NNS	NNS	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	actively	actively	RB	RB	_	8	advmod	_	_
8	transcribe	transcribe	VB	VB	_	5	ccomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	early-response	early-response	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	particular	particular	JJ	JJ	_	17	nmod	_	_
17	those	those	DT	DT	_	8	dep	_	_
18	encoding	encode	VBG	VBG	_	17	acl	_	_
19	cytokines	cytokine	NNS	NNS	_	18	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	chemokines	chemokine	NNS	NNS	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	the	the	DT	DT	_	27	det	_	_
25	high-affinity	high-affinity	JJ	JJ	_	27	amod	_	_
26	surface	surface	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	19	conj	_	_
28	for	for	IN	IN	_	29	case	_	_
29	IgG	igg	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	FcgammaRI	fcgammari	NN	NN	_	29	appos	_	_
32	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	little	little	JJ	JJ	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	known	know	VBN	VBN	_	18	advcl	_	_
5	to	to	TO	TO	_	6	case	_	_
6	date	date	NN	NN	_	4	nmod	_	_
7	about	about	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	regulation	regulation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	several	several	JJ	JJ	_	17	amod	_	_
17	indications	indication	NNS	NNS	_	18	nsubj	_	_
18	point	point	VBP	VBP	_	0	root	_	_
19	to	to	TO	TO	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	18	nmod	_	_
22	for	for	IN	IN	_	25	case	_	_
23	distinct	distinct	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	such	such	JJ	JJ	_	29	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	members	member	NNS	NNS	_	25	nmod	_	_
30	of	of	IN	IN	_	35	case	_	_
31	the	the	DT	DT	_	35	det	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	35	compound	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	STAT	stat	NN	NN	_	32	conj	_	_
35	families	family	NNS	NNS	_	29	nmod	_	_
36	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	whether	whether	IN	IN	_	11	mark	_	_
8	these	these	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	11	nsubj	_	_
11	become	become	VBP	VBP	_	6	ccomp	_	_
12	activated	activate	VBN	VBN	_	11	xcomp	_	_
13	under	under	IN	IN	_	15	case	_	_
14	stimulatory	stimulatory	JJ	JJ	_	15	amod	_	_
15	conditions	condition	NNS	NNS	_	11	nmod	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	known	know	VBN	VBN	_	15	acl:relcl	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	induce	induce	VB	VB	_	18	xcomp	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	neutrophils	neutrophil	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	conventional	conventional	JJ	JJ	_	7	amod	_	_
7	procedures	procedure	NNS	NNS	_	13	nsubj	_	_
8	employed	employ	VBN	VBN	_	7	acl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	prepare	prepare	VB	VB	_	8	xcomp	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	extracts	extract	NNS	NNS	_	10	dobj	_	_
13	cause	cause	VBP	VBP	_	4	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	release	release	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	proteolytic	proteolytic	JJ	JJ	_	18	amod	_	_
18	activities	activity	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	22	nsubjpass	_	_
20	are	be	VBP	VBP	_	22	auxpass	_	_
21	normally	normally	RB	RB	_	22	advmod	_	_
22	stored	store	VBN	VBN	_	18	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	intracellular	intracellular	JJ	JJ	_	25	amod	_	_
25	granules	granule	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	13	punct	_	_
27	resulting	result	VBG	VBG	_	13	advcl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	degradation	degradation	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	various	various	JJ	JJ	_	33	amod	_	_
33	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	STAT	stat	NN	NN	_	36	compound	_	_
36	proteins	protein	NNS	NNS	_	33	conj	_	_
37	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	circumvent	circumvent	VB	VB	_	7	advcl	_	_
3	this	this	DT	DT	_	4	det	_	_
4	problem	problem	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	developed	develop	VBD	VBD	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	alternative	alternative	JJ	JJ	_	10	amod	_	_
10	procedure	procedure	NN	NN	_	7	dobj	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	allowed	allow	VBD	VBD	_	10	acl:relcl	_	_
13	us	we	PRP	PRP	_	12	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	show	show	VB	VB	_	12	xcomp	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	in	in	IN	IN	_	18	case	_	_
18	neutrophils	neutrophil	NNS	NNS	_	23	nmod	_	_
19	,	,	,	,	_	23	punct	_	_
20	LPS	lps	NN	NN	_	23	nsubj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	TNFalpha	tnfalpha	NN	NN	_	20	conj	_	_
23	induce	induce	VBP	VBP	_	15	ccomp	_	_
24	a	a	DT	DT	_	27	det	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	27	compound	_	_
26	DNA-binding	dna-binding	JJ	JJ	_	27	amod	_	_
27	activity	activity	NN	NN	_	23	dobj	_	_
28	which	which	WDT	WDT	_	30	nsubj	_	_
29	essentially	essentially	RB	RB	_	30	advmod	_	_
30	consists	consist	VBZ	VBZ	_	27	acl:relcl	_	_
31	of	of	IN	IN	_	33	case	_	_
32	p50/RelA	p50/rela	NN	NN	_	33	compound	_	_
33	dimers	dimer	NNS	NNS	_	30	nmod	_	_
34	,	,	,	,	_	23	punct	_	_
35	and	and	CC	CC	_	23	cc	_	_
36	that	that	IN	IN	_	38	mark	_	_
37	IFNgamma	ifngamma	NN	NN	_	38	nsubj	_	_
38	promotes	promote	VBZ	VBZ	_	23	conj	_	_
39	the	the	DT	DT	_	40	det	_	_
40	binding	binding	NN	NN	_	38	dobj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	STAT1	stat1	NN	NN	_	43	compound	_	_
43	homodimers	homodimer	NNS	NNS	_	40	nmod	_	_
44	to	to	TO	TO	_	48	case	_	_
45	the	the	DT	DT	_	48	det	_	_
46	IFNgamma	ifngamma	NN	NN	_	48	compound	_	_
47	response	response	NN	NN	_	48	compound	_	_
48	region	region	NN	NN	_	40	nmod	_	_
49	of	of	IN	IN	_	52	case	_	_
50	the	the	DT	DT	_	52	det	_	_
51	FcgammaRI	fcgammari	NN	NN	_	52	compound	_	_
52	promoter	promoter	NN	NN	_	48	nmod	_	_
53	.	.	.	.	_	7	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	neutrophil	neutrophil	NN	NN	_	7	compound	_	_
7	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
8	with	with	IN	IN	_	9	case	_	_
9	GM-CSF	gm-csf	NN	NN	_	7	nmod	_	_
10	results	result	VBZ	VBZ	_	4	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	formation	formation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	STAT5-containing	stat5-containing	JJ	JJ	_	18	amod	_	_
17	DNA-binding	dna-binding	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Collectively	collectively	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	current	current	JJ	JJ	_	5	amod	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	open	open	VBP	VBP	_	0	root	_	_
7	new	new	JJ	JJ	_	8	amod	_	_
8	perspectives	perspective	NNS	NNS	_	6	dobj	_	_
9	about	about	IN	IN	_	10	case	_	_
10	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	likely	likely	JJ	JJ	_	10	acl:relcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	regulate	regulate	VB	VB	_	13	xcomp	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	procedure	procedure	NN	NN	_	9	nsubj	_	_
6	described	describe	VBN	VBN	_	5	acl	_	_
7	herein	herein	RB	RB	_	6	advmod	_	_
8	could	could	MD	MD	_	9	aux	_	_
9	prove	prove	VB	VB	_	0	root	_	_
10	useful	useful	JJ	JJ	_	9	xcomp	_	_
11	in	in	IN	IN	_	14	case	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	types	type	NNS	NNS	_	9	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	express	express	VBP	VBP	_	14	acl:relcl	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	levels	level	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	endogenous	endogenous	JJ	JJ	_	21	amod	_	_
21	proteases	protease	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	BCL-6	bcl-6	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	8	case	_	_
4	normal	normal	JJ	JJ	_	8	amod	_	_
5	germinal	germinal	JJ	JJ	_	8	amod	_	_
6	center	center	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	evidence	evidence	NN	NN	_	2	dep	_	_
11	of	of	IN	IN	_	13	case	_	_
12	somatic	somatic	JJ	JJ	_	13	amod	_	_
13	hypermutation	hypermutation	NN	NN	_	10	nmod	_	_
14	acting	act	VBG	VBG	_	13	acl	_	_
15	outside	outside	IN	IN	_	17	case	_	_
16	Ig	ig	NN	NN	_	17	compound	_	_
17	loci	locus	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
4	involved	involve	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	process	process	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	antigen-driven	antigen-driven	JJ	JJ	_	11	amod	_	_
10	somatic	somatic	JJ	JJ	_	11	amod	_	_
11	hypermutation	hypermutation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Ig	ig	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	unknown	unknown	JJ	JJ	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	but	but	CC	CC	_	16	cc	_	_
19	it	it	PRP	PRP	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	commonly	commonly	RB	RB	_	22	advmod	_	_
22	believed	believe	VBN	VBN	_	16	conj	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	this	this	DT	DT	_	25	det	_	_
25	mechanism	mechanism	NN	NN	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	aux	_	_
27	restricted	restricted	JJ	JJ	_	22	ccomp	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	Ig	ig	NN	NN	_	31	compound	_	_
31	loci	locus	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	B	b	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lymphomas	lymphoma	NNS	NNS	_	5	nsubj	_	_
4	commonly	commonly	RB	RB	_	5	advmod	_	_
5	display	display	VBP	VBP	_	0	root	_	_
6	multiple	multiple	JJ	JJ	_	8	amod	_	_
7	somatic	somatic	JJ	JJ	_	8	amod	_	_
8	mutations	mutation	NNS	NNS	_	5	dobj	_	_
9	clustering	cluster	VBG	VBG	_	8	acl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	5'-regulatory	5'-regulatory	JJ	JJ	_	13	amod	_	_
13	region	region	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	BCL-6	bcl-6	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	a	a	DT	DT	_	18	det	_	_
18	proto-oncogene	proto-oncogene	NN	NN	_	15	appos	_	_
19	encoding	encode	VBG	VBG	_	18	acl	_	_
20	for	for	IN	IN	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	POZ/Zinc	poz/zinc	NN	NN	_	25	compound	_	_
23	finger	finger	NN	NN	_	25	compound	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	repressor	repressor	NN	NN	_	19	nmod	_	_
26	expressed	express	VBN	VBN	_	25	dep	_	_
27	in	in	IN	IN	_	34	case	_	_
28	germinal	germinal	JJ	JJ	_	34	amod	_	_
29	center	center	NN	NN	_	34	compound	_	_
30	(	(	-LRB-	-LRB-	_	34	punct	_	_
31	GC	gc	NN	NN	_	34	compound	_	_
32	)	)	-RRB-	-RRB-	_	34	punct	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	26	nmod	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	required	require	VBN	VBN	_	26	conj	_	_
37	for	for	IN	IN	_	39	case	_	_
38	GC	gc	NN	NN	_	39	compound	_	_
39	formation	formation	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	17	advcl	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	BCL-6	bcl-6	NN	NN	_	5	compound	_	_
5	mutations	mutation	NNS	NNS	_	6	nsubj	_	_
6	represent	represent	VBP	VBP	_	2	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	tumor-associated	tumor-associated	JJ	JJ	_	9	amod	_	_
9	phenomenon	phenomenon	NN	NN	_	6	dobj	_	_
10	or	or	CC	CC	_	6	cc	_	_
11	reflect	reflect	VBP	VBP	_	6	conj	_	_
12	a	a	DT	DT	_	14	det	_	_
13	physiologic	physiologic	JJ	JJ	_	14	amod	_	_
14	mechanism	mechanism	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	screened	screen	VBD	VBD	_	0	root	_	_
18	single	single	JJ	JJ	_	23	amod	_	_
19	human	human	JJ	JJ	_	23	amod	_	_
20	tonsillar	tonsillar	JJ	JJ	_	23	amod	_	_
21	GC	gc	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	dobj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	mutations	mutation	NNS	NNS	_	23	nmod	_	_
26	occurring	occur	VBG	VBG	_	25	acl	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	BCL-6	bcl-6	NN	NN	_	31	compound	_	_
30	5'-noncoding	5'-noncoding	JJ	JJ	_	31	amod	_	_
31	region	region	NN	NN	_	26	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	in	in	IN	IN	_	39	case	_	_
34	the	the	DT	DT	_	39	det	_	_
35	Ig	ig	NN	NN	_	39	compound	_	_
36	variable	variable	JJ	JJ	_	39	amod	_	_
37	heavy	heavy	JJ	JJ	_	39	amod	_	_
38	chain	chain	NN	NN	_	39	compound	_	_
39	sequences	sequence	NNS	NNS	_	31	conj	_	_
40	.	.	.	.	_	17	punct	_	_

1	Thirty	thirty	CD	CD	_	2	nummod	_	_
2	percent	percent	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	GC	gc	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	6	cc	_	_
10	naive	naive	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	displayed	display	VBD	VBD	_	0	root	_	_
15	mutations	mutation	NNS	NNS	_	14	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	742	742	CD	CD	_	20	nummod	_	_
19	bp	bp	NN	NN	_	20	compound	_	_
20	region	region	NN	NN	_	15	nmod	_	_
21	analyzed	analyze	VBN	VBN	_	20	acl	_	_
22	within	within	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	first	first	JJ	JJ	_	25	amod	_	_
25	intron	intron	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	BCL-6	bcl-6	NN	NN	_	25	nmod	_	_
28	(	(	-LRB-	-LRB-	_	32	punct	_	_
29	overall	overall	JJ	JJ	_	30	amod	_	_
30	frequency	frequency	NN	NN	_	32	dep	_	_
31	:	:	:	:	_	32	punct	_	_
32	5	5	CD	CD	_	14	parataxis	_	_
33	x	x	CC	CC	_	32	cc	_	_
34	10(-4)/bp	10(-4)/bp	NN	NN	_	32	conj	_	_
35	)	)	-RRB-	-RRB-	_	32	punct	_	_
36	.	.	.	.	_	14	punct	_	_

1	Accordingly	accordingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	expanded	expand	VBN	VBN	_	5	amod	_	_
5	survey	survey	NN	NN	_	9	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	malignancies	malignancy	NNS	NNS	_	5	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	BCL-6	bcl-6	NN	NN	_	12	compound	_	_
12	mutations	mutation	NNS	NNS	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	aux	_	_
14	restricted	restricted	JJ	JJ	_	9	ccomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	tumors	tumor	NNS	NNS	_	14	nmod	_	_
19	displaying	display	VBG	VBG	_	18	dep	_	_
20	GC	gc	NN	NN	_	23	compound	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	post-GC	post-gc	JJ	JJ	_	20	conj	_	_
23	phenotype	phenotype	NN	NN	_	19	dobj	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	carrying	carry	VBG	VBG	_	19	conj	_	_
26	mutated	mutate	VBN	VBN	_	31	amod	_	_
27	Ig	ig	NN	NN	_	31	compound	_	_
28	variable	variable	JJ	JJ	_	31	amod	_	_
29	heavy	heavy	JJ	JJ	_	31	amod	_	_
30	chain	chain	NN	NN	_	31	compound	_	_
31	sequences	sequence	NNS	NNS	_	25	dobj	_	_
32	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	somatic	somatic	JJ	JJ	_	8	amod	_	_
7	hypermutation	hypermutation	NN	NN	_	8	compound	_	_
8	mechanism	mechanism	NN	NN	_	15	nsubj	_	_
9	active	active	JJ	JJ	_	8	amod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	GC	gc	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	physiologically	physiologically	RB	RB	_	15	advmod	_	_
15	targets	target	VBZ	VBZ	_	3	ccomp	_	_
16	non-Ig	non-ig	JJ	JJ	_	17	amod	_	_
17	sequences	sequence	NNS	NNS	_	15	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	PEBP2betaMYH11	pebp2betamyh11	NN	NN	_	3	compound	_	_
3	fusion	fusion	NN	NN	_	10	nsubj	_	_
4	created	create	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	6	case	_	_
6	Inv(16)(p13;q22)	inv(16)(p13;q22)	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
9	leukemia	leukemia	NN	NN	_	4	nmod	_	_
10	impairs	impair	VBZ	VBZ	_	0	root	_	_
11	neutrophil	neutrophil	NN	NN	_	12	compound	_	_
12	maturation	maturation	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	contributes	contribute	VBZ	VBZ	_	10	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	granulocytic	granulocytic	JJ	JJ	_	17	amod	_	_
17	dysplasia	dysplasia	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Chromosomal	chromosomal	JJ	JJ	_	2	amod	_	_
2	translocations	translocation	NNS	NNS	_	19	nsubjpass	_	_
3	involving	involve	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	genes	gene	NNS	NNS	_	3	dobj	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	11	det	_	_
8	alpha	alpha	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	beta	beta	NN	NN	_	8	conj	_	_
11	subunits	subunit	NNS	NNS	_	6	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	Pebp2/Cbf	pebp2/cbf	NN	NN	_	16	compound	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	11	nmod	_	_
17	have	have	VBP	VBP	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	associated	associate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	acute	acute	JJ	JJ	_	24	amod	_	_
23	myeloid	myeloid	JJ	JJ	_	24	amod	_	_
24	leukemia	leukemia	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	preleukemic	preleukemic	JJ	JJ	_	28	amod	_	_
28	condition	condition	NN	NN	_	24	conj	_	_
29	,	,	,	,	_	28	punct	_	_
30	myelodysplasia	myelodysplasia	NN	NN	_	28	appos	_	_
31	.	.	.	.	_	19	punct	_	_

1	Inv(16)(p13;q22)	inv(16)(p13;q22)	NN	NN	_	2	nsubj	_	_
2	fuses	fuse	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	gene	gene	NN	NN	_	2	dobj	_	_
5	encoding	encode	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	beta	beta	NN	NN	_	8	compound	_	_
8	subunit	subunit	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Pebp2	pebp2	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	MYH11	myh11	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	2	nmod	_	_
15	encoding	encode	VBG	VBG	_	14	acl	_	_
16	a	a	DT	DT	_	21	det	_	_
17	smooth	smooth	JJ	JJ	_	21	amod	_	_
18	muscle	muscle	NN	NN	_	21	compound	_	_
19	myosin	myosin	NN	NN	_	21	compound	_	_
20	heavy	heavy	NN	NN	_	21	compound	_	_
21	chain	chain	NN	NN	_	15	dobj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	Smmhc	smmhc	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	12	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	inv(16)(p13;q22)	inv(16)(p13;q22)	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	9	case	_	_
9	myelopoiesis	myelopoiesis	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	used	use	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	16	det	_	_
14	hMRP8	hmrp8	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	12	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	generate	generate	VB	VB	_	12	advcl	_	_
19	transgenic	transgenic	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	18	dobj	_	_
21	expressing	express	VBG	VBG	_	20	acl	_	_
22	the	the	DT	DT	_	27	det	_	_
23	Pebp2beta	pebp2beta	NN	NN	_	27	compound	_	_
24	Smmhc	smmhc	NN	NN	_	27	compound	_	_
25	chimeric	chimeric	JJ	JJ	_	27	amod	_	_
26	fusion	fusion	NN	NN	_	27	compound	_	_
27	protein	protein	NN	NN	_	21	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	myeloid	myeloid	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	21	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	2	compound	_	_
2	maturation	maturation	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	aux	_	_
4	impaired	impaired	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	PEBP2betaMYH11	pebp2betamyh11	NN	NN	_	8	compound	_	_
7	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	transgenic	transgenic	JJ	JJ	_	4	amod	_	_
4	mice	mouse	NNS	NNS	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	15	advcl	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	numbers	number	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	circulating	circulate	VBG	VBG	_	10	amod	_	_
10	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
13	bone	bone	NN	NN	_	14	compound	_	_
14	marrow	marrow	NN	NN	_	15	nsubj	_	_
15	contained	contain	VBD	VBD	_	0	root	_	_
16	increased	increase	VBN	VBN	_	17	amod	_	_
17	numbers	number	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	immature	immature	JJ	JJ	_	21	amod	_	_
20	neutrophilic	neutrophilic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	exhibited	exhibit	VBD	VBD	_	21	acl:relcl	_	_
25	abnormal	abnormal	JJ	JJ	_	26	amod	_	_
26	characteristics	characteristic	NNS	NNS	_	24	dobj	_	_
27	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	PEBP2betaMYH11	pebp2betamyh11	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	neutrophilic	neutrophilic	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	colonies	colony	NNS	NNS	_	7	nmod	_	_
10	derived	derive	VBN	VBN	_	9	acl	_	_
11	from	from	IN	IN	_	13	case	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
13	progenitors	progenitor	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Coexpression	coexpression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	PEBP2betaMYH11	pebp2betamyh11	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	NRAS	nra	NNS	NNS	_	4	conj	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	severe	severe	JJ	JJ	_	12	amod	_	_
12	phenotype	phenotype	NN	NN	_	8	dobj	_	_
13	characterized	characterize	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	17	case	_	_
15	abnormal	abnormal	JJ	JJ	_	17	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	morphology	morphology	NN	NN	_	13	nmod	_	_
18	indicative	indicative	JJ	JJ	_	17	amod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	granulocytic	granulocytic	JJ	JJ	_	21	amod	_	_
21	dysplasia	dysplasia	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PEBP2betaMYH11	pebp2betamyh11	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	impair	impair	VB	VB	_	3	ccomp	_	_
8	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	provide	provide	VBP	VBP	_	7	conj	_	_
12	evidence	evidence	NN	NN	_	11	dobj	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	alterations	alteration	NNS	NNS	_	18	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Pebp2	pebp2	NN	NN	_	14	nmod	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	contribute	contribute	VB	VB	_	12	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	genesis	genesis	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	myelodysplasia	myelodysplasia	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	lymphokine	lymphokine	NN	NN	_	6	nmod:npmod	_	_
6	activated	activated	JJ	JJ	_	8	amod	_	_
7	killer	killer	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	8	conj	_	_
11	from	from	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	8	nmod	_	_
13	receiving	receive	VBG	VBG	_	12	acl	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	immunotherapy	immunotherapy	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Administration	administration	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cytokine	cytokine	NN	NN	_	1	nmod	_	_
5	interleukin-2	interleukin-2	NN	NN	_	4	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-2	il-2	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	result	result	VB	VB	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	therapeutic	therapeutic	JJ	JJ	_	13	amod	_	_
13	benefits	benefit	NNS	NNS	_	10	nmod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	individuals	individual	NNS	NNS	_	13	nmod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	renal	renal	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	carcinoma	carcinoma	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	melanoma	melanoma	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	analysis	analysis	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	families	family	NNS	NNS	_	5	nmod	_	_
11	AP-1	ap-1	NN	NN	_	10	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	Sp1	sp1	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	11	appos	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	signal	signal	NN	NN	_	19	compound	_	_
19	transducers	transducer	NNS	NNS	_	10	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	activators	activator	NNS	NNS	_	19	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	transcription	transcription	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	STAT	stat	NN	NN	_	19	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	31	case	_	_
28	cancer	cancer	NN	NN	_	31	compound	_	_
29	patients	patient	NNS	NNS	_	31	nmod:poss	_	_
30	'	'	POS	POS	_	31	case	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
32	before	before	IN	IN	_	36	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	after	after	IN	IN	_	32	conj	_	_
35	IL-2	il-2	NN	NN	_	36	compound	_	_
36	immunotherapy	immunotherapy	NN	NN	_	10	nmod	_	_
37	,	,	,	,	_	3	punct	_	_
38	as	as	IN	IN	_	39	mark	_	_
39	assessed	assess	VBN	VBN	_	3	advcl	_	_
40	by	by	IN	IN	_	43	case	_	_
41	a	a	DT	DT	_	43	det	_	_
42	gel-shift	gel-shift	JJ	JJ	_	43	amod	_	_
43	assay	assay	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	surrogate	surrogate	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	immunotherapy	immunotherapy	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	the	the	DT	DT	_	10	det	_	_
10	incubation	incubation	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	16	case	_	_
12	fresh	fresh	JJ	JJ	_	16	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	10	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PBMC	pbmc	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	from	from	IN	IN	_	22	case	_	_
21	healthy	healthy	JJ	JJ	_	22	amod	_	_
22	individuals	individual	NNS	NNS	_	16	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	IL-2	il-2	NN	NN	_	10	nmod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	several	several	JJ	JJ	_	27	amod	_	_
27	days	day	NNS	NNS	_	10	nmod	_	_
28	,	,	,	,	_	10	punct	_	_
29	resulting	result	VBG	VBG	_	10	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	production	production	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	39	case	_	_
34	lymphokine-activated	lymphokine-activated	JJ	JJ	_	35	amod	_	_
35	killer	killer	NN	NN	_	39	compound	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	LAK	lak	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	activity	activity	NN	NN	_	32	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	cultures	culture	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	10	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	describe	describe	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	profile	profile	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	these	these	DT	DT	_	18	det	_	_
17	different	different	JJ	JJ	_	18	amod	_	_
18	populations	population	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	assess	assess	VB	VB	_	8	conj	_	_
22	whether	whether	IN	IN	_	26	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	patterns	pattern	NNS	NNS	_	26	nsubj	_	_
25	observed	observe	VBN	VBN	_	24	acl	_	_
26	correlated	correlate	VBD	VBD	_	21	ccomp	_	_
27	with	with	IN	IN	_	29	case	_	_
28	functional	functional	JJ	JJ	_	29	amod	_	_
29	differences	difference	NNS	NNS	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	Prior	prior	JJ	JJ	_	6	case	_	_
2	to	to	TO	TO	_	1	mwe	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vivo	vivo	FW	FW	_	3	dep	_	_
5	IL-2	il-2	NN	NN	_	6	compound	_	_
6	administration	administration	NN	NN	_	19	nmod	_	_
7	,	,	,	,	_	19	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	typical	typical	JJ	JJ	_	11	amod	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	pattern	pattern	NN	NN	_	19	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	PBMC	pbmc	NNS	NNS	_	14	nmod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	patients	patient	NNS	NNS	_	16	nmod	_	_
19	resembled	resemble	VBD	VBD	_	0	root	_	_
20	that	that	DT	DT	_	19	xcomp	_	_
21	seen	see	VBN	VBN	_	20	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	fresh	fresh	JJ	JJ	_	24	amod	_	_
24	PBMC	pbmc	NNS	NNS	_	21	nmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	healthy	healthy	JJ	JJ	_	27	amod	_	_
27	individuals	individual	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	Over	over	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	3-week	3-week	JJ	JJ	_	4	amod	_	_
4	course	course	NN	NN	_	23	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	therapy	therapy	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	23	punct	_	_
9	in	in	IN	IN	_	11	case	_	_
10	most	most	JJS	JJS	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	23	nmod	_	_
12	the	the	DT	DT	_	14	det	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	patterns	pattern	NNS	NNS	_	23	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	AP-1	ap-1	NN	NN	_	18	compound	_	_
17	,	,	,	,	_	18	punct	_	_
18	Sp1	sp1	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	and	and	CC	CC	_	18	cc	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
22	proteins	protein	NNS	NNS	_	18	conj	_	_
23	changed	change	VBD	VBD	_	0	root	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	resemble	resemble	VB	VB	_	23	xcomp	_	_
26	those	those	DT	DT	_	25	xcomp	_	_
27	seen	see	VBN	VBN	_	26	acl	_	_
28	in	in	IN	IN	_	29	case	_	_
29	PBMC	pbmc	NNS	NNS	_	27	nmod	_	_
30	activated	activate	VBN	VBN	_	29	acl	_	_
31	by	by	IN	IN	_	32	case	_	_
32	IL-2	il-2	NN	NN	_	30	nmod	_	_
33	in	in	FW	FW	_	34	compound	_	_
34	vitro	vitro	FW	FW	_	30	advmod	_	_
35	.	.	.	.	_	23	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	cells	cell	NNS	NNS	_	11	nsubj	_	_
5	obtained	obtain	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	8	case	_	_
7	IL-2-treated	il-2-treated	JJ	JJ	_	8	amod	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	have	have	VB	VB	_	0	root	_	_
12	low-level	low-level	JJ	JJ	_	14	amod	_	_
13	constitutive	constitutive	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	STAT	stat	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	14	nmod	_	_
19	as	as	IN	IN	_	20	dep	_	_
20	did	do	VBD	VBD	_	11	advcl	_	_
21	LAK	lak	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	20	nsubj	_	_
23	.	.	.	.	_	11	punct	_	_

1	When	when	WRB	WRB	_	7	advmod	_	_
2	these	these	DT	DT	_	4	det	_	_
3	patient	patient	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubjpass	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	further	further	RB	RB	_	7	advmod	_	_
7	stimulated	stimulate	VBN	VBN	_	20	advcl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IL-2	il-2	NN	NN	_	7	nmod	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	7	advmod	_	_
12	,	,	,	,	_	20	punct	_	_
13	additional	additional	JJ	JJ	_	14	amod	_	_
14	differences	difference	NNS	NNS	_	20	nsubjpass	_	_
15	in	in	IN	IN	_	18	case	_	_
16	STAT	stat	NN	NN	_	18	compound	_	_
17	induction	induction	NN	NN	_	18	compound	_	_
18	patterns	pattern	NNS	NNS	_	14	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	noted	note	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	further	further	JJ	JJ	_	5	amod	_	_
5	information	information	NN	NN	_	3	dobj	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	events	event	NNS	NNS	_	5	nmod	_	_
10	occurring	occur	VBG	VBG	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	generated	generate	VBN	VBN	_	13	acl	_	_
15	through	through	IN	IN	_	21	case	_	_
16	in	in	FW	FW	_	21	amod	_	_
17	vivo	vivo	FW	FW	_	16	dep	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	in	in	FW	FW	_	16	conj	_	_
20	vitro	vitro	FW	FW	_	19	dep	_	_
21	administration	administration	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	5	punct	_	_
25	and	and	CC	CC	_	5	cc	_	_
26	further	further	RB	RB	_	5	conj	_	_
27	document	document	VBP	VBP	_	26	dep	_	_
28	that	that	IN	IN	_	30	mark	_	_
29	there	there	EX	EX	_	30	expl	_	_
30	is	be	VBZ	VBZ	_	26	dep	_	_
31	not	not	RB	RB	_	30	neg	_	_
32	a	a	DT	DT	_	34	det	_	_
33	precise	precise	JJ	JJ	_	34	amod	_	_
34	congruence	congruence	NN	NN	_	30	nsubj	_	_
35	between	between	IN	IN	_	36	case	_	_
36	PBMC	pbmc	NNS	NNS	_	34	nmod	_	_
37	activated	activate	VBN	VBN	_	36	acl	_	_
38	in	in	FW	FW	_	39	compound	_	_
39	vivo	vivo	FW	FW	_	40	advmod	_	_
40	and	and	CC	CC	_	37	advmod	_	_
41	in	in	FW	FW	_	42	compound	_	_
42	vitro	vitro	FW	FW	_	40	advmod	_	_
43	by	by	IN	IN	_	44	case	_	_
44	IL-2	il-2	NN	NN	_	37	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	anergy	anergy	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	high	high	JJ	JJ	_	8	amod	_	_
8	concentrations	concentration	NNS	NNS	_	1	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	immunodominant	immunodominant	JJ	JJ	_	12	amod	_	_
11	native	native	JJ	JJ	_	12	amod	_	_
12	peptide	peptide	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	accompanied	accompany	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	17	case	_	_
16	IL-10	il-10	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	a	a	DT	DT	_	20	det	_	_
20	block	block	NN	NN	_	17	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	JNK	jnk	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	10	nsubj	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	induce	induce	VB	VB	_	2	acl	_	_
5	anergy	anergy	NN	NN	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	antigen-specific	antigen-specific	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	has	have	VBZ	VBZ	_	0	root	_	_
11	potential	potential	JJ	JJ	_	13	amod	_	_
12	therapeutic	therapeutic	JJ	JJ	_	13	amod	_	_
13	value	value	NN	NN	_	10	dobj	_	_
14	for	for	IN	IN	_	15	mark	_	_
15	altering	alter	VBG	VBG	_	13	acl	_	_
16	pathologic	pathologic	JJ	JJ	_	18	amod	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	responses	response	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	undertaken	undertake	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	further	further	RB	RB	_	7	advmod	_	_
7	analyze	analyze	VB	VB	_	4	xcomp	_	_
8	changes	change	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	signaling	signaling	NN	NN	_	11	conj	_	_
15	during	during	IN	IN	_	17	case	_	_
16	anergy	anergy	NN	NN	_	17	compound	_	_
17	induction	induction	NN	NN	_	8	nmod	_	_
18	using	use	VBG	VBG	_	7	xcomp	_	_
19	high	high	JJ	JJ	_	20	amod	_	_
20	concentrations	concentration	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	native	native	JJ	JJ	_	24	amod	_	_
23	peptide	peptide	NN	NN	_	24	compound	_	_
24	ligand	ligand	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	43	case	_	_
26	tetanus	tetanus	NN	NN	_	27	compound	_	_
27	toxoid	toxoid	NN	NN	_	43	amod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	TT	tt	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	-	-	:	:	_	27	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	myelin	myelin	JJ	JJ	_	35	amod	_	_
34	basic	basic	JJ	JJ	_	35	amod	_	_
35	protein	protein	NN	NN	_	39	nmod:npmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	MBP	mbp	NN	NN	_	35	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	-specific	-specific	JJ	JJ	_	27	conj	_	_
40	human	human	JJ	JJ	_	43	amod	_	_
41	T	t	NN	NN	_	43	compound	_	_
42	cell	cell	NN	NN	_	43	compound	_	_
43	lines	line	NNS	NNS	_	24	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	TT-selected	tt-selected	JJ	JJ	_	5	amod	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	8	nsubjpass	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	rendered	render	VBN	VBN	_	0	root	_	_
9	unresponsive	unresponsive	JJ	JJ	_	8	xcomp	_	_
10	to	to	TO	TO	_	13	case	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	dominant	dominant	JJ	JJ	_	13	amod	_	_
13	epitope	epitope	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	dose-dependent	dose-dependent	JJ	JJ	_	17	amod	_	_
17	manner	manner	NN	NN	_	9	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	IC50	ic50	NN	NN	_	20	nsubj	_	_
20	=	=	JJ	JJ	_	9	dep	_	_
21	0.03	0.03	CD	CD	_	22	nummod	_	_
22	microg/ml	microg/ml	NN	NN	_	20	dobj	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TT-selected	tt-selected	JJ	JJ	_	3	amod	_	_
3	line	line	NN	NN	_	17	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	as	as	RB	RB	_	3	cc	_	_
6	well	well	RB	RB	_	5	mwe	_	_
7	as	as	IN	IN	_	5	mwe	_	_
8	three	three	CD	CD	_	11	nummod	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	clones	clone	NNS	NNS	_	3	conj	_	_
12	established	establish	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	line	line	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	3	punct	_	_
17	continued	continue	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	produce	produce	VB	VB	_	17	xcomp	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	significantly	significantly	RB	RB	_	23	advmod	_	_
23	increased	increase	VBD	VBD	_	17	conj	_	_
24	IL-4	il-4	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	IL-10	il-10	NN	NN	_	24	conj	_	_
27	production	production	NN	NN	_	23	dobj	_	_
28	when	when	WRB	WRB	_	31	advmod	_	_
29	anergy	anergy	NN	NN	_	31	nsubjpass	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	induced	induce	VBN	VBN	_	17	advcl	_	_
32	with	with	IN	IN	_	34	case	_	_
33	high	high	JJ	JJ	_	34	amod	_	_
34	concentrations	concentration	NNS	NNS	_	31	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	immunodominant	immunodominant	JJ	JJ	_	38	amod	_	_
38	epitope	epitope	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	17	punct	_	_

1	JNK	jnk	NN	NN	_	3	compound	_	_
2	enzymatic	enzymatic	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	blocked	block	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	anergized	anergize	VBN	VBN	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	MBP-selected	mbp-selected	JJ	JJ	_	3	amod	_	_
3	line	line	NN	NN	_	7	nsubjpass	_	_
4	could	could	MD	MD	_	7	aux	_	_
5	likewise	likewise	RB	RB	_	7	advmod	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	rendered	render	VBN	VBN	_	0	root	_	_
8	unresponsive	unresponsive	JJ	JJ	_	7	xcomp	_	_
9	by	by	IN	IN	_	10	case	_	_
10	incubation	incubation	NN	NN	_	7	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	supraoptimal	supraoptimal	JJ	JJ	_	13	amod	_	_
13	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	immunodominant	immunodominant	JJ	JJ	_	16	amod	_	_
16	peptide	peptide	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	anergy	anergy	NN	NN	_	19	compound	_	_
19	induction	induction	NN	NN	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	accompanied	accompany	VBN	VBN	_	7	conj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	IL-10	il-10	NN	NN	_	24	compound	_	_
24	release	release	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Both	both	DT	DT	_	4	det	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	7	nsubjpass	_	_
5	could	could	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	anergized	anergize	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	autopresentation	autopresentation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	native	native	JJ	JJ	_	13	amod	_	_
13	peptide	peptide	NN	NN	_	10	nmod	_	_
14	since	since	IN	IN	_	17	mark	_	_
15	anergy	anergy	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	7	advcl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cultures	culture	NNS	NNS	_	17	nmod	_	_
20	lacking	lack	VBG	VBG	_	19	acl	_	_
21	fresh	fresh	JJ	JJ	_	23	amod	_	_
22	antigen-presenting	antigen-presenting	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	mitogen-activated	mitogen-activated	JJ	JJ	_	9	amod	_	_
7	protein	protein	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	cascade	cascade	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	blocked	block	VBN	VBN	_	3	ccomp	_	_
12	when	when	WRB	WRB	_	15	advmod	_	_
13	anergy	anergy	NN	NN	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	induced	induce	VBN	VBN	_	11	advcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	concentrations	concentration	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	soluble	soluble	JJ	JJ	_	21	amod	_	_
21	peptide	peptide	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	4	amod	_	_
2	15-amino	15-amino	JJ	JJ	_	4	amod	_	_
3	acid	acid	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NFATx1	nfatx1	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	possibly	possibly	RB	RB	_	9	advmod	_	_
9	created	create	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	tissue-specific	tissue-specific	JJ	JJ	_	12	amod	_	_
12	splicing	splicing	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	essential	essential	JJ	JJ	_	9	conj	_	_
16	for	for	IN	IN	_	18	case	_	_
17	transactivation	transactivation	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	NFAT	nfat	NN	NN	_	2	nsubj	_	_
2	regulates	regulate	VBZ	VBZ	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	cytokine	cytokine	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	other	other	JJ	JJ	_	12	amod	_	_
11	immunoregulatory	immunoregulatory	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	8	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	NFATx	nfatx	NN	NN	_	3	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	one	one	CD	CD	_	4	acl:relcl	_	_
9	of	of	IN	IN	_	11	case	_	_
10	four	four	CD	CD	_	11	nummod	_	_
11	members	member	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	NFAT	nfat	NN	NN	_	15	compound	_	_
15	family	family	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	preferentially	preferentially	RB	RB	_	22	advmod	_	_
22	expressed	express	VBN	VBN	_	8	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	thymus	thymus	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	peripheral	peripheral	JJ	JJ	_	29	amod	_	_
28	blood	blood	NN	NN	_	29	compound	_	_
29	leukocytes	leukocyte	NNS	NNS	_	25	conj	_	_
30	,	,	,	,	_	4	punct	_	_
31	and	and	CC	CC	_	4	cc	_	_
32	an	a	DT	DT	_	33	det	_	_
33	isoform	isoform	NN	NN	_	4	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	NFATx	nfatx	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	33	punct	_	_
37	NFATx1	nfatx1	NN	NN	_	33	appos	_	_
38	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	showing	show	VBG	VBG	_	4	acl	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	15	15	CD	CD	_	9	nummod	_	_
8	amino	amino	NN	NN	_	9	compound	_	_
9	acids	acid	NNS	NNS	_	17	nsubjpass	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	13	amod	_	_
13	end	end	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NFATx1	nfatx1	NN	NN	_	13	nmod	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	required	require	VBN	VBN	_	5	ccomp	_	_
18	for	for	IN	IN	_	22	case	_	_
19	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
20	maximum	maximum	JJ	JJ	_	22	amod	_	_
21	transactivation	transactivation	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	Jurkat	jurkat	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	fusion	fusion	NN	NN	_	15	nsubj	_	_
3	between	between	IN	IN	_	7	case	_	_
4	these	these	DT	DT	_	7	det	_	_
5	15	15	CD	CD	_	7	nummod	_	_
6	amino	amino	NN	NN	_	7	compound	_	_
7	acids	acid	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	13	det	_	_
10	GAL4	gal4	NN	NN	_	13	compound	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	7	conj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	capable	capable	JJ	JJ	_	0	root	_	_
16	of	of	IN	IN	_	17	mark	_	_
17	transactivating	transactivate	VBG	VBG	_	15	advcl	_	_
18	reporters	reporter	NNS	NNS	_	17	dobj	_	_
19	driven	drive	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	GAL4	gal4	NN	NN	_	25	compound	_	_
23	DNA	dna	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	this	this	DT	DT	_	7	det	_	_
4	15-amino	15-amino	JJ	JJ	_	7	amod	_	_
5	acid	acid	NN	NN	_	7	compound	_	_
6	transactivation	transactivation	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	well	well	RB	RB	_	10	advmod	_	_
10	conserved	conserve	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	NFAT	nfat	NN	NN	_	14	compound	_	_
13	family	family	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	although	although	IN	IN	_	31	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	sequences	sequence	NNS	NNS	_	31	nsubjpass	_	_
19	contiguous	contiguous	JJ	JJ	_	18	amod	_	_
20	to	to	TO	TO	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	23	amod	_	_
23	regions	region	NNS	NNS	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	NFAT	nfat	NN	NN	_	27	compound	_	_
27	family	family	NN	NN	_	23	nmod	_	_
28	are	be	VBP	VBP	_	31	auxpass	_	_
29	much	much	JJ	JJ	_	30	advmod	_	_
30	less	less	RBR	RBR	_	31	advmod	_	_
31	conserved	conserve	VBN	VBN	_	10	advcl	_	_
32	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	three	three	CD	CD	_	6	nummod	_	_
5	additional	additional	JJ	JJ	_	6	amod	_	_
6	isoforms	isoform	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NFATx	nfatx	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	designated	designate	VBN	VBN	_	6	acl	_	_
11	NFATx2	nfatx2	NN	NN	_	10	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	NFATx3	nfatx3	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	NFATx4	nfatx4	NN	NN	_	11	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	transactivation	transactivation	NN	NN	_	3	compound	_	_
3	sequence	sequence	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	altered	alter	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	tissue-specific	tissue-specific	JJ	JJ	_	9	amod	_	_
8	alternative	alternative	JJ	JJ	_	9	amod	_	_
9	splicing	splicing	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	newly	newly	RB	RB	_	12	advmod	_	_
12	isolated	isolate	VBN	VBN	_	14	amod	_	_
13	NFATx	nfatx	NN	NN	_	14	compound	_	_
14	isoforms	isoform	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	resulting	result	VBG	VBG	_	5	xcomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	lower	lower	JJR	JJR	_	20	amod	_	_
19	transactivation	transactivation	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	Jurkat	jurkat	NN	NN	_	24	compound	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	NFATx1	nfatx1	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	predominantly	predominantly	RB	RB	_	3	advmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	thymus	thymus	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	leukocyte	leukocyte	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	3	punct	_	_
13	while	while	IN	IN	_	17	mark	_	_
14	the	the	DT	DT	_	16	det	_	_
15	skeletal	skeletal	JJ	JJ	_	16	amod	_	_
16	muscle	muscle	NN	NN	_	17	nsubj	_	_
17	expressed	express	VBD	VBD	_	3	advcl	_	_
18	primarily	primarily	RB	RB	_	17	advmod	_	_
19	NFATx2	nfatx2	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	transcription	transcription	NN	NN	_	15	nsubjpass	_	_
6	from	from	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	NFAT	nfat	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	activated	activate	VBN	VBN	_	0	root	_	_
16	strongly	strongly	RB	RB	_	15	advmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	NFATx1	nfatx1	NN	NN	_	15	nmod	_	_
19	but	but	CC	CC	_	15	cc	_	_
20	only	only	RB	RB	_	21	advmod	_	_
21	weakly	weakly	RB	RB	_	15	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	NFATx2	nfatx2	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	15-amino	15-amino	JJ	JJ	_	8	amod	_	_
7	acid	acid	NN	NN	_	8	compound	_	_
8	sequence	sequence	NN	NN	_	15	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NFATx1	nfatx1	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	15	cop	_	_
12	a	a	DT	DT	_	15	det	_	_
13	major	major	JJ	JJ	_	15	amod	_	_
14	transactivation	transactivation	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	3	ccomp	_	_
16	required	require	VBN	VBN	_	15	acl	_	_
17	for	for	IN	IN	_	18	case	_	_
18	induction	induction	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	genes	gene	NNS	NNS	_	18	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	NFATx1	nfatx1	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	18	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	possibly	possibly	RB	RB	_	28	advmod	_	_
28	regulates	regulate	VBZ	VBZ	_	15	conj	_	_
29	NFAT	nfat	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	28	dobj	_	_
31	through	through	IN	IN	_	34	case	_	_
32	tissue-specific	tissue-specific	JJ	JJ	_	34	amod	_	_
33	alternative	alternative	JJ	JJ	_	34	amod	_	_
34	splicing	splicing	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	critical	critical	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	10	case	_	_
5	the	the	DT	DT	_	10	det	_	_
6	p75	p75	NN	NN	_	10	compound	_	_
7	tumor	tumor	NN	NN	_	10	compound	_	_
8	necrosis	necrosis	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	3	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	p75TNF-R	p75tnf-r	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	organ	organ	NN	NN	_	16	compound	_	_
16	inflammation	inflammation	NN	NN	_	3	nmod	_	_
17	independent	independent	JJ	JJ	_	16	amod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	TNF	tnf	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	lymphotoxin	lymphotoxin	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	or	or	CC	CC	_	19	cc	_	_
25	the	the	DT	DT	_	26	det	_	_
26	p55TNF-R	p55tnf-r	NN	NN	_	19	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	overwhelming	overwhelming	JJ	JJ	_	3	amod	_	_
3	evidence	evidence	NN	NN	_	49	nmod	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	enhanced	enhance	VBN	VBN	_	6	amod	_	_
6	production	production	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	p75	p75	NN	NN	_	13	compound	_	_
10	tumor	tumor	NN	NN	_	13	compound	_	_
11	necrosis	necrosis	NN	NN	_	13	compound	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	p75TNF-R	p75tnf-r	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	accompanies	accompany	VBZ	VBZ	_	3	ccomp	_	_
18	development	development	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	specific	specific	JJ	JJ	_	23	amod	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	pathologies	pathology	NNS	NNS	_	18	nmod	_	_
24	such	such	JJ	JJ	_	27	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	multi-organ	multi-organ	JJ	JJ	_	27	amod	_	_
27	failure	failure	NN	NN	_	23	nmod	_	_
28	during	during	IN	IN	_	29	case	_	_
29	sepsis	sepsis	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	inflammatory	inflammatory	JJ	JJ	_	33	amod	_	_
32	liver	liver	NN	NN	_	33	compound	_	_
33	disease	disease	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	pancreatitis	pancreatitis	NN	NN	_	29	conj	_	_
36	,	,	,	,	_	29	punct	_	_
37	respiratory	respiratory	JJ	JJ	_	39	amod	_	_
38	distress	distress	NN	NN	_	39	compound	_	_
39	syndrome	syndrome	NN	NN	_	29	conj	_	_
40	,	,	,	,	_	29	punct	_	_
41	or	or	CC	CC	_	29	cc	_	_
42	AIDS	aids	NN	NN	_	29	conj	_	_
43	,	,	,	,	_	49	punct	_	_
44	the	the	DT	DT	_	45	det	_	_
45	function	function	NN	NN	_	49	nsubj	_	_
46	of	of	IN	IN	_	48	case	_	_
47	this	this	DT	DT	_	48	det	_	_
48	receptor	receptor	NN	NN	_	45	nmod	_	_
49	remains	remain	VBZ	VBZ	_	0	root	_	_
50	poorly	poorly	RB	RB	_	51	advmod	_	_
51	defined	define	VBN	VBN	_	49	xcomp	_	_
52	in	in	FW	FW	_	53	compound	_	_
53	vivo	vivo	FW	FW	_	49	advmod	_	_
54	.	.	.	.	_	49	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	at	at	IN	IN	_	6	case	_	_
6	levels	level	NNS	NNS	_	20	nmod	_	_
7	relevant	relevant	JJ	JJ	_	6	amod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	disease	disease	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	20	punct	_	_
12	production	production	NN	NN	_	20	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	p75TNF-R	p75tnf-r	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	transgenic	transgenic	JJ	JJ	_	19	amod	_	_
19	mice	mouse	NNS	NNS	_	12	nmod	_	_
20	results	result	VBZ	VBZ	_	2	ccomp	_	_
21	in	in	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	severe	severe	JJ	JJ	_	25	amod	_	_
24	inflammatory	inflammatory	JJ	JJ	_	25	amod	_	_
25	syndrome	syndrome	NN	NN	_	20	nmod	_	_
26	involving	involve	VBG	VBG	_	25	dep	_	_
27	mainly	mainly	RB	RB	_	26	advmod	_	_
28	the	the	DT	DT	_	29	det	_	_
29	pancreas	pancreas	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	29	punct	_	_
31	liver	liver	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	kidney	kidney	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	lung	lung	NN	NN	_	29	conj	_	_
37	,	,	,	,	_	26	punct	_	_
38	and	and	CC	CC	_	26	cc	_	_
39	characterized	characterize	VBN	VBN	_	26	conj	_	_
40	by	by	IN	IN	_	44	case	_	_
41	constitutively	constitutively	RB	RB	_	42	advmod	_	_
42	increased	increase	VBN	VBN	_	44	amod	_	_
43	NF-kappaB	nf-kappab	NN	NN	_	44	compound	_	_
44	activity	activity	NN	NN	_	39	nmod	_	_
45	in	in	IN	IN	_	51	case	_	_
46	the	the	DT	DT	_	51	det	_	_
47	peripheral	peripheral	JJ	JJ	_	51	amod	_	_
48	blood	blood	NN	NN	_	51	compound	_	_
49	mononuclear	mononuclear	JJ	JJ	_	51	amod	_	_
50	cell	cell	NN	NN	_	51	compound	_	_
51	compartment	compartment	NN	NN	_	44	nmod	_	_
52	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	process	process	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	evolve	evolve	VB	VB	_	4	xcomp	_	_
7	independently	independently	RB	RB	_	6	advmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TNF	tnf	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	lymphotoxin	lymphotoxin	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	12	conj	_	_
16	,	,	,	,	_	12	punct	_	_
17	or	or	CC	CC	_	12	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	p55TNF-R	p55tnf-r	NN	NN	_	12	conj	_	_
20	,	,	,	,	_	6	punct	_	_
21	although	although	IN	IN	_	28	mark	_	_
22	coexpression	coexpression	NN	NN	_	28	nsubj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	human	human	JJ	JJ	_	27	amod	_	_
26	TNF	tnf	NN	NN	_	27	compound	_	_
27	transgene	transgene	NN	NN	_	22	nmod	_	_
28	accelerated	accelerate	VBD	VBD	_	6	advcl	_	_
29	pathology	pathology	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	independent	independent	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	enhanced	enhance	VBN	VBN	_	10	amod	_	_
9	p75TNF-R	p75tnf-r	NN	NN	_	10	compound	_	_
10	production	production	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	pathogenesis	pathogenesis	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	disease	disease	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	implicate	implicate	VBP	VBP	_	3	conj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	direct	direct	JJ	JJ	_	21	amod	_	_
21	involvement	involvement	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	receptor	receptor	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	wide	wide	JJ	JJ	_	28	amod	_	_
28	range	range	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	inflammatory	inflammatory	JJ	JJ	_	32	amod	_	_
32	pathologies	pathology	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	interleukin	interleukin	NN	NN	_	7	compound	_	_
3	2	2	CD	CD	_	7	nummod	_	_
4	receptor	receptor	NN	NN	_	7	compound	_	_
5	alpha	alpha	NN	NN	_	7	compound	_	_
6	chain/CD25	chain/cd25	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	10	nsubj	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	a	a	DT	DT	_	10	det	_	_
10	target	target	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	17	case	_	_
12	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
13	factor	factor	NN	NN	_	17	compound	_	_
14	of	of	IN	IN	_	17	amod	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	13	case	_	_
4	the	the	DT	DT	_	13	det	_	_
5	murine	murine	JJ	JJ	_	13	amod	_	_
6	interleukin	interleukin	NN	NN	_	13	compound	_	_
7	(	(	-LRB-	-LRB-	_	13	punct	_	_
8	IL	il	NN	NN	_	13	compound	_	_
9	)	)	-RRB-	-RRB-	_	13	punct	_	_
10	-2	-2	CD	CD	_	13	nummod	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	alpha	alpha	NN	NN	_	13	compound	_	_
13	chain/CD25	chain/cd25	NN	NN	_	2	nmod	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	strongly	strongly	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	0	root	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	level	level	NN	NN	_	16	nmod	_	_
21	after	after	IN	IN	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
6	factor	factor	NN	NN	_	14	compound	_	_
7	of	of	IN	IN	_	14	amod	_	_
8	activated	activate	VBN	VBN	_	14	amod	_	_
9	T	t	NN	NN	_	14	compound	_	_
10	cell	cell	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	NF-AT	nf-at	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	factors	factor	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	2	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	control	control	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	CD25	cd25	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	induction	induction	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	NF-ATp	nf-atp	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	NF-ATc	nf-atc	NN	NN	_	1	conj	_	_
4	bind	bind	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	sites	site	NNS	NNS	_	4	nmod	_	_
8	around	around	IN	IN	_	9	case	_	_
9	positions	position	NNS	NNS	_	7	nmod	_	_
10	-585	-585	CD	CD	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	-650	-650	CD	CD	_	10	conj	_	_
13	located	located	JJ	JJ	_	9	amod	_	_
14	upstream	upstream	JJ	JJ	_	13	advmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	proximal	proximal	JJ	JJ	_	19	amod	_	_
18	CD25	cd25	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Immediately	immediately	RB	RB	_	2	advmod	_	_
2	3'	3'	JJ	JJ	_	11	nsubj	_	_
3	from	from	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	NF-AT	nf-at	NN	NN	_	6	compound	_	_
6	motifs	motif	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	nonconsensus	nonconsensus	JJ	JJ	_	9	amod	_	_
9	sites	site	NNS	NNS	_	11	nsubj	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	located	located	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	binding	binding	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	AP-1-like	ap-1-like	JJ	JJ	_	17	amod	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Mutations	mutation	NNS	NNS	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	sites	site	NNS	NNS	_	1	nmod	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	suppress	suppress	VBP	VBP	_	3	acl:relcl	_	_
6	NF-AT	nf-at	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	5	dobj	_	_
8	impair	impair	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	strong	strong	JJ	JJ	_	14	amod	_	_
13	NF-ATp-mediated	nf-atp-mediated	JJ	JJ	_	14	amod	_	_
14	transactivation	transactivation	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CD25	cd25	NN	NN	_	18	compound	_	_
18	promoter	promoter	NN	NN	_	10	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
4	from	from	IN	IN	_	6	case	_	_
5	NF-ATp-deficient	nf-atp-deficient	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	14	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	14	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	CD25	cd25	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	14	aux	_	_
13	severely	severely	RB	RB	_	14	advmod	_	_
14	impaired	impaired	JJ	JJ	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	leading	lead	VBG	VBG	_	14	advcl	_	_
17	to	to	TO	TO	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	delayed	delay	VBN	VBN	_	22	amod	_	_
20	IL-2	il-2	NN	NN	_	22	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	16	nmod	_	_
23	after	after	IN	IN	_	22	dep	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	31	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	TCR	tcr	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	/CD3	/cd3	NN	NN	_	31	compound	_	_
31	stimulation	stimulation	NN	NN	_	23	dep	_	_
32	.	.	.	.	_	14	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	NF-AT	nf-at	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	faithful	faithful	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	high	high	JJ	JJ	_	17	amod	_	_
15	affinity	affinity	NN	NN	_	17	compound	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	a	a	DT	DT	_	21	det	_	_
20	close	close	JJ	JJ	_	21	amod	_	_
21	link	link	NN	NN	_	6	conj	_	_
22	between	between	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	TCR-mediated	tcr-mediated	JJ	JJ	_	25	amod	_	_
25	induction	induction	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	33	case	_	_
27	IL-2	il-2	NN	NN	_	33	compound	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	IL-2	il-2	NN	NN	_	27	conj	_	_
30	receptor	receptor	NN	NN	_	33	compound	_	_
31	alpha	alpha	NN	NN	_	33	compound	_	_
32	chain	chain	NN	NN	_	33	compound	_	_
33	promoters	promoter	NNS	NNS	_	25	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	both	both	DT	DT	_	39	nsubjpass	_	_
36	of	of	IN	IN	_	37	case	_	_
37	which	which	WDT	WDT	_	35	nmod	_	_
38	are	be	VBP	VBP	_	39	auxpass	_	_
39	regulated	regulate	VBN	VBN	_	33	acl:relcl	_	_
40	by	by	IN	IN	_	42	case	_	_
41	NF-AT	nf-at	NN	NN	_	42	compound	_	_
42	factors	factor	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Position	position	NN	NN	_	2	compound	_	_
2	effect	effect	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	translocations	translocation	NNS	NNS	_	2	nmod	_	_
5	involving	involve	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	inactive	inactive	JJ	JJ	_	9	amod	_	_
8	X	x	NN	NN	_	9	compound	_	_
9	chromosome	chromosome	NN	NN	_	5	dobj	_	_
10	:	:	:	:	_	2	punct	_	_
11	physical	physical	JJ	JJ	_	12	amod	_	_
12	linkage	linkage	NN	NN	_	17	nsubj	_	_
13	to	to	TO	TO	_	14	case	_	_
14	XIC/XIST	xic/xist	NN	NN	_	12	nmod	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	lead	lead	VB	VB	_	2	dep	_	_
18	to	to	TO	TO	_	22	case	_	_
19	long-range	long-range	JJ	JJ	_	22	amod	_	_
20	de	de	FW	FW	_	22	amod	_	_
21	novo	novo	FW	FW	_	20	dep	_	_
22	inactivation	inactivation	NN	NN	_	17	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	differentiated	differentiate	VBN	VBN	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Given	give	VBN	VBN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	reported	report	VBN	VBN	_	6	amod	_	_
4	long-range	long-range	JJ	JJ	_	6	amod	_	_
5	cis-inactivating	cis-inactivating	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	30	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	XIST	xist	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	early	early	JJ	JJ	_	14	amod	_	_
13	embryonic	embryonic	JJ	JJ	_	14	amod	_	_
14	development	development	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	lack	lack	NN	NN	_	6	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	requirement	requirement	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	X-chromosome-specific	x-chromosome-specific	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	19	nmod	_	_
23	for	for	IN	IN	_	24	mark	_	_
24	propagating	propagate	VBG	VBG	_	22	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	inactive	inactive	JJ	JJ	_	27	amod	_	_
27	state	state	NN	NN	_	24	dobj	_	_
28	,	,	,	,	_	30	punct	_	_
29	there	there	EX	EX	_	30	expl	_	_
30	exists	exist	VBZ	VBZ	_	0	root	_	_
31	the	the	DT	DT	_	32	det	_	_
32	possibility	possibility	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	cis	cis	JJ	JJ	_	35	amod	_	_
35	inactivation	inactivation	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	autosomal	autosomal	JJ	JJ	_	38	amod	_	_
38	material	material	JJ	JJ	_	35	nmod	_	_
39	after	after	IN	IN	_	42	case	_	_
40	de	de	FW	FW	_	42	amod	_	_
41	novo	novo	FW	FW	_	40	dep	_	_
42	translocation	translocation	NN	NN	_	30	nmod	_	_
43	to	to	TO	TO	_	47	case	_	_
44	an	a	DT	DT	_	47	det	_	_
45	inactive	inactive	JJ	JJ	_	47	amod	_	_
46	X	x	NN	NN	_	47	compound	_	_
47	chromosome	chromosome	NN	NN	_	42	nmod	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	Xi	xi	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	in	in	IN	IN	_	53	case	_	_
52	differentiated	differentiate	VBN	VBN	_	53	amod	_	_
53	cells	cell	NNS	NNS	_	47	nmod	_	_
54	.	.	.	.	_	30	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	de	de	FW	FW	_	7	amod	_	_
5	novo	novo	FW	FW	_	4	dep	_	_
6	radiation-induced	radiation-induced	JJ	JJ	_	7	amod	_	_
7	translocations	translocation	NNS	NNS	_	3	dobj	_	_
8	between	between	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	Xi	xi	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	autosomes	autosome	NNS	NNS	_	10	conj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	study	study	VB	VB	_	3	advcl	_	_
15	the	the	DT	DT	_	16	det	_	_
16	maintenance	maintenance	NN	NN	_	14	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	spreading	spreading	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	X-chromosome	x-chromosome	NN	NN	_	21	compound	_	_
21	inactivation	inactivation	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	X	x	NN	NN	_	24	compound	_	_
24	inactivation	inactivation	NN	NN	_	21	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	in	in	IN	IN	_	30	case	_	_
27	relation	relation	NN	NN	_	30	dep	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	position	position	NN	NN	_	16	nmod	_	_
31	of	of	IN	IN	_	38	case	_	_
32	the	the	DT	DT	_	38	det	_	_
33	X-inactivation	x-inactivation	NN	NN	_	34	compound	_	_
34	center	center	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	XIC	xic	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	/XIST	/xist	NN	NN	_	30	nmod	_	_
39	in	in	IN	IN	_	41	case	_	_
40	differentiated	differentiate	VBN	VBN	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	30	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Autosome/Xi	autosome/xi	NN	NN	_	2	compound	_	_
2	translocations	translocation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	fluorescence	fluorescence	NN	NN	_	9	compound	_	_
7	in	in	FW	FW	_	9	amod	_	_
8	situ	situ	FW	FW	_	7	dep	_	_
9	hybridization	hybridization	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	FISH	fish	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	activation	activation	NN	NN	_	3	compound	_	_
3	status	status	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	chromosomes	chromosome	NNS	NNS	_	3	nmod	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	translocation	translocation	NN	NN	_	7	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	determined	determine	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	simultaneous	simultaneous	JJ	JJ	_	16	amod	_	_
15	immunocytogenetic	immunocytogenetic	JJ	JJ	_	16	amod	_	_
16	studies	study	NNS	NNS	_	12	nmod	_	_
17	using	use	VBG	VBG	_	16	acl	_	_
18	antibodies	antibody	NNS	NNS	_	17	dobj	_	_
19	against	against	IN	IN	_	21	case	_	_
20	either	either	CC	CC	_	21	cc:preconj	_	_
21	BrdU	brdu	NN	NN	_	18	nmod	_	_
22	incorporated	incorporate	VBN	VBN	_	21	acl	_	_
23	at	at	IN	IN	_	26	case	_	_
24	late	late	JJ	JJ	_	26	amod	_	_
25	S	s	NN	NN	_	26	compound	_	_
26	phase	phase	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	21	cc	_	_
28	acetylated	acetylate	VBN	VBN	_	30	amod	_	_
29	histone	histone	NN	NN	_	30	compound	_	_
30	H4	h4	NN	NN	_	21	conj	_	_
31	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	position	position	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	XIC/XIST	xic/xist	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	reciprocal	reciprocal	JJ	JJ	_	8	amod	_	_
8	products	product	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	translocation	translocation	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	determined	determine	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	XIST-specific	xist-specific	JJ	JJ	_	16	amod	_	_
16	FISH	fish	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	computer	computer	NN	NN	_	19	compound	_	_
19	enhancement	enhancement	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	experiments	experiment	NNS	NNS	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Xq13	xq13	NN	NN	_	7	compound	_	_
7	region	region	NN	NN	_	11	nsubjpass	_	_
8	carrying	carry	VBG	VBG	_	7	acl	_	_
9	XIC/XIST	xic/xist	NN	NN	_	8	dobj	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	localized	localize	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	computer	computer	NN	NN	_	14	compound	_	_
14	enhancement	enhancement	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	DAPI	dapi	NN	NN	_	19	compound	_	_
18	banding	banding	NN	NN	_	19	compound	_	_
19	pattern	pattern	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	study	study	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	differentiated	differentiate	VBN	VBN	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	provides	provide	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	visual	visual	JJ	JJ	_	9	amod	_	_
9	demonstration	demonstration	NN	NN	_	6	dobj	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	physical	physical	JJ	JJ	_	12	amod	_	_
12	separation	separation	NN	NN	_	17	nsubj	_	_
13	from	from	IN	IN	_	14	case	_	_
14	XIC/XIST	xic/xist	NN	NN	_	12	nmod	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	result	result	VB	VB	_	9	ccomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	reactivation	reactivation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	inactive	inactive	JJ	JJ	_	23	amod	_	_
22	X-chromosome	x-chromosome	NN	NN	_	23	compound	_	_
23	material	material	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	that	that	IN	IN	_	30	mark	_	_
26	X	x	NN	NN	_	27	compound	_	_
27	inactivation	inactivation	NN	NN	_	30	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	30	auxpass	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	spread	spread	VBN	VBN	_	17	conj	_	_
31	to	to	TO	TO	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	translocated	translocate	VBN	VBN	_	34	amod	_	_
34	autosomes	autosome	NNS	NNS	_	30	nmod	_	_
35	irrespective	irrespective	RB	RB	_	38	advmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	position	position	NN	NN	_	30	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	XIC/XIST	xic/xist	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	physical	physical	JJ	JJ	_	6	amod	_	_
6	linkage	linkage	NN	NN	_	11	nsubj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	XIC/XIST	xic/xist	NN	NN	_	6	nmod	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	lead	lead	VB	VB	_	3	ccomp	_	_
12	to	to	TO	TO	_	15	case	_	_
13	de	de	FW	FW	_	15	amod	_	_
14	novo	novo	FW	FW	_	13	dep	_	_
15	inactivation	inactivation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	autosomal	autosomal	JJ	JJ	_	18	amod	_	_
18	material	material	JJ	JJ	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Potent	potent	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	HIV	hiv	NN	NN	_	7	compound	_	_
5	type	type	NN	NN	_	7	compound	_	_
6	1	1	CD	CD	_	7	nummod	_	_
7	replication	replication	NN	NN	_	2	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	antiinflammatory	antiinflammatory	JJ	JJ	_	11	amod	_	_
11	alkaloid	alkaloid	NN	NN	_	2	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	cepharanthine	cepharanthine	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	in	in	IN	IN	_	19	case	_	_
16	chronically	chronically	RB	RB	_	19	advmod	_	_
17	infected	infected	JJ	JJ	_	19	amod	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	2	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Cepharanthine	cepharanthine	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	biscoclaurine	biscoclaurine	JJ	JJ	_	5	amod	_	_
5	alkaloid	alkaloid	NN	NN	_	0	root	_	_
6	isolated	isolate	VBN	VBN	_	5	acl	_	_
7	from	from	IN	IN	_	10	case	_	_
8	Stephania	stephania	FW	FW	_	10	compound	_	_
9	cepharantha	cepharantha	FW	FW	_	10	compound	_	_
10	Hayata	hayata	FW	FW	_	6	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	5	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	have	have	VB	VB	_	14	xcomp	_	_
17	antiinflammatory	antiinflammatory	JJ	JJ	_	23	amod	_	_
18	,	,	,	,	_	17	punct	_	_
19	antiallergic	antiallergic	JJ	JJ	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	immunomodulatory	immunomodulatory	JJ	JJ	_	17	conj	_	_
23	activities	activity	NNS	NNS	_	16	dobj	_	_
24	in	in	FW	FW	_	25	compound	_	_
25	vivo	vivo	FW	FW	_	16	advmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	9	mark	_	_
2	several	several	JJ	JJ	_	4	amod	_	_
3	inflammatory	inflammatory	JJ	JJ	_	4	amod	_	_
4	cytokines	cytokine	NNS	NNS	_	9	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	oxidative	oxidative	JJ	JJ	_	7	amod	_	_
7	stresses	stress	NNS	NNS	_	4	conj	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	involved	involve	VBN	VBN	_	18	advcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	pathogenesis	pathogenesis	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	infection	infection	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	investigated	investigate	VBD	VBD	_	0	root	_	_
19	the	the	DT	DT	_	21	det	_	_
20	inhibitory	inhibitory	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	cepharanthine	cepharanthine	NN	NN	_	21	nmod	_	_
24	on	on	IN	IN	_	42	case	_	_
25	tumor	tumor	NN	NN	_	28	compound	_	_
26	necrosis	necrosis	NN	NN	_	28	compound	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	alpha	alpha	NN	NN	_	40	nmod:npmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TNF-alpha	tnf-alpha	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	-	-	CC	CC	_	28	cc	_	_
33	and	and	CC	CC	_	28	cc	_	_
34	phorbol	phorbol	NN	NN	_	36	compound	_	_
35	12-myristate	12-myristate	NN	NN	_	36	compound	_	_
36	13-acetate	13-acetate	NN	NN	_	28	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	PMA	pma	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	-induced	-induced	JJ	JJ	_	42	amod	_	_
41	HIV-1	hiv-1	NN	NN	_	42	compound	_	_
42	replication	replication	NN	NN	_	21	nmod	_	_
43	in	in	IN	IN	_	47	case	_	_
44	chronically	chronically	RB	RB	_	47	advmod	_	_
45	infected	infected	JJ	JJ	_	47	amod	_	_
46	cell	cell	NN	NN	_	47	compound	_	_
47	lines	line	NNS	NNS	_	21	nmod	_	_
48	.	.	.	.	_	18	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	chronically	chronically	RB	RB	_	5	advmod	_	_
3	HIV-1-infected	hiv-1-infected	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	19	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	U1	u1	NN	NN	_	5	appos	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	monocytic	monocytic	JJ	JJ	_	7	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	ACH-2	ach-2	NN	NN	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	T	t	NN	NN	_	15	nmod:npmod	_	_
15	lymphocytic	lymphocytic	JJ	JJ	_	12	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	5	punct	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	stimulated	stimulate	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	21	case	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	19	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	PMA	pma	NN	NN	_	21	conj	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	cultured	culture	VBN	VBN	_	19	conj	_	_
26	in	in	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	dep	_	_
28	presence	presence	NN	NN	_	31	dep	_	_
29	of	of	IN	IN	_	31	case	_	_
30	various	various	JJ	JJ	_	31	amod	_	_
31	concentrations	concentration	NNS	NNS	_	25	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	compound	compound	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	19	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	replication	replication	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	p24	p24	NN	NN	_	8	compound	_	_
7	antigen	antigen	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	27	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cepharanthine	cepharanthine	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	16	case	_	_
7	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
8	long	long	JJ	JJ	_	10	amod	_	_
9	terminal	terminal	JJ	JJ	_	10	amod	_	_
10	repeat	repeat	NN	NN	_	14	nmod:npmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	LTR	ltr	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-driven	-driven	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	3	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	kappaB	kappab	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	activation	activation	NN	NN	_	16	conj	_	_
25	were	be	VBD	VBD	_	27	auxpass	_	_
26	also	also	RB	RB	_	27	advmod	_	_
27	examined	examine	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	Cepharanthine	cepharanthine	NN	NN	_	2	compound	_	_
2	dose	dose	NN	NN	_	4	nsubj	_	_
3	dependently	dependently	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	12	case	_	_
8	TNF-alpha-	tnf-alpha-	NN	NN	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	PMA-stimulated	pma-stimulated	JJ	JJ	_	8	conj	_	_
11	U1	u1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	12	cc	_	_
15	in	in	IN	IN	_	17	case	_	_
16	ACH-2	ach-2	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Its	its	PRP$	PRP$	_	7	nmod:poss	_	_
2	50	50	CD	CD	_	3	compound	_	_
3	%	%	NN	NN	_	7	amod	_	_
4	effective	effective	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cytotoxic	cytotoxic	JJ	JJ	_	4	conj	_	_
7	concentrations	concentration	NNS	NNS	_	12	nsubj	_	_
8	were	be	VBD	VBD	_	12	cop	_	_
9	0.016	0.016	CD	CD	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	2.2	2.2	CD	CD	_	9	conj	_	_
12	microg/ml	microg/ml	NN	NN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	PMA-stimulated	pma-stimulated	JJ	JJ	_	16	amod	_	_
15	U1	u1	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	respectively	respectively	RB	RB	_	12	advmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Cepharanthine	cepharanthine	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	suppress	suppress	VB	VB	_	3	xcomp	_	_
6	HIV-1	hiv-1	NN	NN	_	7	nmod:npmod	_	_
7	LTR-driven	ltr-driven	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	dobj	_	_
10	through	through	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	inhibition	inhibition	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	cepharanthine	cepharanthine	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	a	a	DT	DT	_	10	det	_	_
8	highly	highly	RB	RB	_	9	advmod	_	_
9	potent	potent	JJ	JJ	_	10	amod	_	_
10	inhibitor	inhibitor	NN	NN	_	3	ccomp	_	_
11	of	of	IN	IN	_	13	case	_	_
12	HIV-1	hiv-1	NN	NN	_	13	compound	_	_
13	replication	replication	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	20	case	_	_
15	a	a	DT	DT	_	20	det	_	_
16	chronically	chronically	RB	RB	_	20	advmod	_	_
17	infected	infected	JJ	JJ	_	20	amod	_	_
18	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Since	since	IN	IN	_	14	mark	_	_
2	biscoclaurine	biscoclaurine	NN	NN	_	3	compound	_	_
3	alkaloids	alkaloid	NNS	NNS	_	14	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	containing	contain	VBG	VBG	_	3	acl	_	_
6	cepharanthine	cepharanthine	NN	NN	_	5	dobj	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	major	major	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	are	be	VBP	VBP	_	14	auxpass	_	_
13	widely	widely	RB	RB	_	14	advmod	_	_
14	used	use	VBN	VBN	_	31	advcl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	23	case	_	_
21	various	various	JJ	JJ	_	23	amod	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	diseases	disease	NNS	NNS	_	19	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	Japan	Japan	NNP	NNP	_	14	nmod	_	_
26	,	,	,	,	_	31	punct	_	_
27	cepharanthine	cepharanthine	NN	NN	_	31	nsubjpass	_	_
28	should	should	MD	MD	_	31	aux	_	_
29	be	be	VB	VB	_	31	auxpass	_	_
30	further	further	RB	RB	_	31	advmod	_	_
31	pursued	pursue	VBN	VBN	_	0	root	_	_
32	for	for	IN	IN	_	35	case	_	_
33	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
34	chemotherapeutic	chemotherapeutic	JJ	JJ	_	35	amod	_	_
35	potential	potential	NN	NN	_	31	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	HIV-1-infected	hiv-1-infected	JJ	JJ	_	38	amod	_	_
38	patients	patient	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	31	punct	_	_

1	Prostaglandin	prostaglandin	NN	NN	_	2	compound	_	_
2	E2	e2	NN	NN	_	3	nsubj	_	_
3	Up-regulates	up-regulate	VBZ	VBZ	_	0	root	_	_
4	HIV-1	hiv-1	NN	NN	_	7	nmod:npmod	_	_
5	long	long	JJ	JJ	_	7	amod	_	_
6	terminal	terminal	JJ	JJ	_	7	amod	_	_
7	repeat-driven	repeat-driven	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	3	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	via	via	IN	IN	_	18	case	_	_
14	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	-independent	-independent	JJ	JJ	_	14	conj	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	3	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Replication	replication	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
5	virus	virus	NN	NN	_	6	compound	_	_
6	type-1	type-1	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV-1	hiv-1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	dependent	dependent	JJ	JJ	_	0	root	_	_
13	on	on	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	state	state	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	infected	infected	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	modulated	modulate	VBN	VBN	_	12	conj	_	_
25	by	by	IN	IN	_	26	case	_	_
26	interactions	interaction	NNS	NNS	_	24	nmod	_	_
27	between	between	IN	IN	_	32	case	_	_
28	viral	viral	JJ	JJ	_	32	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	host	host	NN	NN	_	31	nmod:npmod	_	_
31	cellular	cellular	JJ	JJ	_	28	conj	_	_
32	factors	factor	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Prostaglandin	prostaglandin	NN	NN	_	2	compound	_	_
2	E2	e2	NN	NN	_	13	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PGE2	pge2	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	a	a	DT	DT	_	10	det	_	_
8	pleiotropic	pleiotropic	JJ	JJ	_	10	amod	_	_
9	immunomodulatory	immunomodulatory	JJ	JJ	_	10	amod	_	_
10	molecule	molecule	NN	NN	_	2	appos	_	_
11	,	,	,	,	_	2	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	at	at	IN	IN	_	16	case	_	_
15	elevated	elevated	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	13	nmod	_	_
17	during	during	IN	IN	_	19	case	_	_
18	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
19	infection	infection	NN	NN	_	13	nmod	_	_
20	as	as	RB	RB	_	19	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	during	during	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	course	course	NN	NN	_	19	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	other	other	JJ	JJ	_	29	amod	_	_
28	pathogenic	pathogenic	JJ	JJ	_	29	amod	_	_
29	infections	infection	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	1G5	1g5	NN	NN	_	26	nmod	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	8	det	_	_
5	Jurkat-derived	jurkat-derived	JJ	JJ	_	8	amod	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	2	appos	_	_
9	stably	stably	RB	RB	_	10	advmod	_	_
10	transfected	transfect	VBN	VBN	_	8	acl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	luciferase	luciferase	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	driven	drive	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	20	case	_	_
17	HIV-1	hiv-1	NN	NN	_	20	compound	_	_
18	long	long	JJ	JJ	_	20	amod	_	_
19	terminal	terminal	JJ	JJ	_	20	amod	_	_
20	repeat	repeat	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	LTR	ltr	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	found	find	VBD	VBD	_	0	root	_	_
27	that	that	IN	IN	_	30	mark	_	_
28	PGE2	pge2	NN	NN	_	30	nsubj	_	_
29	markedly	markedly	RB	RB	_	30	advmod	_	_
30	enhanced	enhance	VBD	VBD	_	26	ccomp	_	_
31	HIV-1	hiv-1	NN	NN	_	32	nmod:npmod	_	_
32	LTR-mediated	ltr-mediated	JJ	JJ	_	35	amod	_	_
33	reporter	reporter	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	30	dobj	_	_
36	.	.	.	.	_	26	punct	_	_

1	Experiments	experiment	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	conducted	conduct	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	identify	identify	VB	VB	_	4	xcomp	_	_
7	second	second	JJ	JJ	_	8	amod	_	_
8	messengers	messenger	NNS	NNS	_	6	dobj	_	_
9	involved	involve	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	14	case	_	_
11	this	this	DT	DT	_	14	det	_	_
12	PGE2-dependent	pge2-dependent	JJ	JJ	_	14	amod	_	_
13	up-regulating	up-regulate	VBG	VBG	_	14	amod	_	_
14	effect	effect	NN	NN	_	9	nmod	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	element	element	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	HIV-1	hiv-1	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	present	present	VBP	VBP	_	0	root	_	_
7	evidence	evidence	NN	NN	_	6	dobj	_	_
8	indicating	indicate	VBG	VBG	_	7	acl	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	signal	signal	NN	NN	_	12	compound	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	16	nsubj	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	PGE2	pge2	NN	NN	_	13	nmod	_	_
16	necessitate	necessitate	VBP	VBP	_	8	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	participation	participation	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cyclic	cyclic	JJ	JJ	_	21	amod	_	_
21	AMP	amp	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	protein	protein	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	A	a	NN	NN	_	21	conj	_	_
26	,	,	,	,	_	21	punct	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	Ca2+	ca2+	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Experiments	experiment	NNS	NNS	_	8	nsubj	_	_
2	conducted	conduct	VBN	VBN	_	1	acl	_	_
3	with	with	IN	IN	_	7	case	_	_
4	different	different	JJ	JJ	_	7	amod	_	_
5	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
6	LTR-based	ltr-based	NN	NN	_	7	compound	_	_
7	vectors	vector	NNS	NNS	_	2	nmod	_	_
8	suggested	suggest	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	17	mark	_	_
10	PGE2-mediated	pge2-mediated	JJ	JJ	_	12	amod	_	_
11	activation	activation	NN	NN	_	12	compound	_	_
12	effect	effect	NN	NN	_	17	nsubjpass	_	_
13	on	on	IN	IN	_	15	case	_	_
14	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	transduced	transduce	VBN	VBN	_	8	ccomp	_	_
18	via	via	IN	IN	_	24	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	24	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	-independent	-independent	JJ	JJ	_	20	conj	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathways	pathway	NNS	NNS	_	17	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	PGE2-dependent	pge2-dependent	JJ	JJ	_	9	amod	_	_
8	activating	activate	VBG	VBG	_	9	amod	_	_
9	effect	effect	NN	NN	_	2	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	9	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	further	further	RB	RB	_	15	advmod	_	_
15	confirmed	confirm	VBN	VBN	_	0	root	_	_
16	using	use	VBG	VBG	_	15	dep	_	_
17	a	a	DT	DT	_	21	det	_	_
18	kappaB-regulated	kappab-regulated	JJ	JJ	_	21	amod	_	_
19	luciferase	luciferase	NN	NN	_	21	compound	_	_
20	encoding	encoding	NN	NN	_	21	compound	_	_
21	vector	vector	NN	NN	_	16	dobj	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	by	by	IN	IN	_	27	case	_	_
24	electrophoretic	electrophoretic	JJ	JJ	_	27	amod	_	_
25	mobility	mobility	NN	NN	_	27	compound	_	_
26	shift	shift	NN	NN	_	27	compound	_	_
27	assays	assay	NNS	NNS	_	16	conj	_	_
28	.	.	.	.	_	15	punct	_	_

1	Results	result	NNS	NNS	_	19	nsubj	_	_
2	from	from	IN	IN	_	8	case	_	_
3	Northern	northern	NN	NN	_	4	compound	_	_
4	blot	blot	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	flow	flow	NN	NN	_	7	nmod:npmod	_	_
7	cytometric	cytometric	JJ	JJ	_	4	conj	_	_
8	analyses	analysis	NNS	NNS	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	as	as	RB	RB	_	8	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	the	the	DT	DT	_	14	det	_	_
14	use	use	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	selective	selective	JJ	JJ	_	18	amod	_	_
18	antagonist	antagonist	NN	NN	_	14	nmod	_	_
19	indicated	indicate	VBD	VBD	_	0	root	_	_
20	that	that	IN	IN	_	35	mark	_	_
21	PGE2	pge2	NN	NN	_	22	compound	_	_
22	modulation	modulation	NN	NN	_	35	nsubjpass	_	_
23	of	of	IN	IN	_	28	case	_	_
24	HIV-1	hiv-1	NN	NN	_	25	nmod:npmod	_	_
25	LTR-driven	ltr-driven	JJ	JJ	_	28	amod	_	_
26	reporter	reporter	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	22	nmod	_	_
29	in	in	IN	IN	_	33	case	_	_
30	studied	study	VBN	VBN	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	lymphoid	lymphoid	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	28	nmod	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	transduced	transduce	VBN	VBN	_	19	ccomp	_	_
36	via	via	IN	IN	_	40	case	_	_
37	the	the	DT	DT	_	40	det	_	_
38	EP4	ep4	NN	NN	_	40	compound	_	_
39	receptor	receptor	NN	NN	_	40	compound	_	_
40	subtype	subtype	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	secretion	secretion	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	PGE2	pge2	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	macrophages	macrophage	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	16	case	_	_
11	response	response	NN	NN	_	16	dep	_	_
12	to	to	TO	TO	_	16	case	_	_
13	infection	infection	NN	NN	_	16	compound	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	inflammatory	inflammatory	JJ	JJ	_	13	conj	_	_
16	activators	activator	NNS	NNS	_	5	nmod	_	_
17	could	could	MD	MD	_	18	aux	_	_
18	induce	induce	VB	VB	_	3	ccomp	_	_
19	signaling	signaling	NN	NN	_	20	compound	_	_
20	events	event	NNS	NNS	_	18	dobj	_	_
21	resulting	result	VBG	VBG	_	20	acl	_	_
22	in	in	IN	IN	_	23	case	_	_
23	activation	activation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	proviral	proviral	JJ	JJ	_	26	amod	_	_
26	DNA	dna	NN	NN	_	23	nmod	_	_
27	present	present	JJ	JJ	_	26	amod	_	_
28	into	into	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	latently	latently	RB	RB	_	32	advmod	_	_
32	infected	infect	VBN	VBN	_	30	acl	_	_
33	with	with	IN	IN	_	34	case	_	_
34	HIV-1	hiv-1	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Fcgamma	fcgamma	NN	NN	_	2	nmod:npmod	_	_
2	receptor-mediated	receptor-mediated	JJ	JJ	_	6	amod	_	_
3	mitogen-activated	mitogen-activated	JJ	JJ	_	6	amod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	independent	independent	JJ	JJ	_	0	root	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Ras	ras	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	Receptors	receptor	NNS	NNS	_	17	nsubj	_	_
2	for	for	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	Fc	fc	NN	NN	_	5	compound	_	_
5	portion	portion	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	immunoglobulin	immunoglobulin	NN	NN	_	8	compound	_	_
8	molecules	molecule	NNS	NNS	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	FcR	fcr	NNS	NNS	_	1	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	present	present	JJ	JJ	_	1	amod	_	_
13	on	on	IN	IN	_	16	case	_	_
14	leukocyte	leukocyte	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	membranes	membrane	NNS	NNS	_	12	nmod	_	_
17	mediate	mediate	VBP	VBP	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	large	large	JJ	JJ	_	20	amod	_	_
20	number	number	NN	NN	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	20	nmod	_	_
24	that	that	WDT	WDT	_	27	nsubj	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	very	very	RB	RB	_	27	advmod	_	_
27	important	important	JJ	JJ	_	23	acl:relcl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	host	host	NN	NN	_	30	compound	_	_
30	defense	defense	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	including	include	VBG	VBG	_	33	case	_	_
33	phagocytosis	phagocytosis	NN	NN	_	30	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	cytotoxicity	cytotoxicity	NN	NN	_	33	conj	_	_
37	,	,	,	,	_	33	punct	_	_
38	production	production	NN	NN	_	33	conj	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	secretion	secretion	NN	NN	_	38	conj	_	_
41	of	of	IN	IN	_	43	case	_	_
42	inflammatory	inflammatory	JJ	JJ	_	43	amod	_	_
43	mediators	mediator	NNS	NNS	_	38	nmod	_	_
44	,	,	,	,	_	33	punct	_	_
45	and	and	CC	CC	_	33	cc	_	_
46	modulation	modulation	NN	NN	_	33	conj	_	_
47	of	of	IN	IN	_	50	case	_	_
48	the	the	DT	DT	_	50	det	_	_
49	immune	immune	JJ	JJ	_	50	amod	_	_
50	response	response	NN	NN	_	46	nmod	_	_
51	.	.	.	.	_	17	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	FcR	fcr	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	immune	immune	JJ	JJ	_	6	amod	_	_
6	complexes	complex	NNS	NNS	_	1	nmod	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	first	first	RB	RB	_	7	advmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	protein-tyrosine	protein-tyrosine	JJ	JJ	_	14	amod	_	_
14	kinases	kinase	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	events	event	NNS	NNS	_	19	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	follow	follow	VBP	VBP	_	3	acl:relcl	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	transduce	transduce	VBP	VBP	_	5	conj	_	_
9	signals	signal	NNS	NNS	_	8	dobj	_	_
10	from	from	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	receptors	receptor	NNS	NNS	_	8	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	8	nmod	_	_
16	are	be	VBP	VBP	_	19	auxpass	_	_
17	still	still	RB	RB	_	19	advmod	_	_
18	poorly	poorly	RB	RB	_	19	advmod	_	_
19	defined	define	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	signal	signal	NN	NN	_	7	compound	_	_
6	transduction	transduction	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	3	dobj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	Fc	fc	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	7	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	leads	lead	VBZ	VBZ	_	7	acl:relcl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	production	production	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cytokines	cytokine	NNS	NNS	_	17	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	FcR	fcr	NNS	NNS	_	1	nmod	_	_
4	,	,	,	,	_	1	punct	_	_
5	on	on	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	THP-1	thp-1	NN	NN	_	10	compound	_	_
8	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	by	by	IN	IN	_	14	case	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	1	nmod	_	_
15	resulted	result	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	interleukin	interleukin	NN	NN	_	27	compound	_	_
26	1	1	CD	CD	_	27	nummod	_	_
27	production	production	NN	NN	_	18	conj	_	_
28	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	responses	response	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	completely	completely	RB	RB	_	5	advmod	_	_
5	blocked	block	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	inhibitors	inhibitor	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	20	nmod	_	_
3	,	,	,	,	_	20	punct	_	_
4	expression	expression	NN	NN	_	20	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	dominant	dominant	JJ	JJ	_	8	amod	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	mutants	mutant	NNS	NNS	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Ras	ras	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Raf-1	raf-1	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	4	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	did	do	VBD	VBD	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	have	have	VB	VB	_	0	root	_	_
21	any	any	DT	DT	_	22	det	_	_
22	effect	effect	NN	NN	_	20	dobj	_	_
23	on	on	IN	IN	_	27	case	_	_
24	FcR-mediated	fcr-mediated	JJ	JJ	_	27	amod	_	_
25	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
26	factor	factor	NN	NN	_	27	compound	_	_
27	activation	activation	NN	NN	_	20	nmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	suggesting	suggest	VBG	VBG	_	20	advcl	_	_
30	that	that	IN	IN	_	42	mark	_	_
31	the	the	DT	DT	_	34	det	_	_
32	mitogen-activated	mitogen-activated	JJ	JJ	_	34	amod	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	kinase	kinase	NN	NN	_	39	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	MAPK	mapk	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	signaling	signaling	NN	NN	_	39	compound	_	_
39	pathway	pathway	NN	NN	_	42	nsubjpass	_	_
40	was	be	VBD	VBD	_	42	auxpass	_	_
41	not	not	RB	RB	_	42	neg	_	_
42	used	use	VBN	VBN	_	29	ccomp	_	_
43	by	by	IN	IN	_	45	case	_	_
44	these	these	DT	DT	_	45	det	_	_
45	receptors	receptor	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	20	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	MAPK	mapk	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	easily	easily	RB	RB	_	7	advmod	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	in	in	FW	FW	_	12	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	assays	assay	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	after	after	IN	IN	_	16	case	_	_
15	FcR	fcr	NNS	NNS	_	16	compound	_	_
16	cross-linking	cross-linking	NN	NN	_	7	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Using	use	VBG	VBG	_	16	advcl	_	_
2	the	the	DT	DT	_	13	det	_	_
3	specific	specific	JJ	JJ	_	13	amod	_	_
4	MAPK/extracellular	mapk/extracellular	JJ	JJ	_	5	amod	_	_
5	signal-regulated	signal-regulated	JJ	JJ	_	7	amod	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	MAPK	mapk	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	inhibitor	inhibitor	NN	NN	_	13	compound	_	_
13	PD98059	pd98059	NN	NN	_	1	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	found	find	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	MAPK	mapk	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	21	nsubj	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	necessary	necessary	JJ	JJ	_	16	ccomp	_	_
22	for	for	IN	IN	_	24	case	_	_
23	FcR-dependent	fcr-dependent	JJ	JJ	_	24	amod	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	NF-kappaB	nf-kappab	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	23	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	pathway	pathway	NN	NN	_	23	nsubj	_	_
9	from	from	IN	IN	_	11	case	_	_
10	Fc	fc	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	leading	lead	VBG	VBG	_	11	acl	_	_
13	to	to	TO	TO	_	14	case	_	_
14	expression	expression	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	different	different	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	important	important	JJ	JJ	_	17	amod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	leukocyte	leukocyte	NN	NN	_	21	compound	_	_
21	biology	biology	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	8	punct	_	_
23	initiates	initiate	VBZ	VBZ	_	4	ccomp	_	_
24	with	with	IN	IN	_	26	case	_	_
25	tyrosine	tyrosine	NN	NN	_	26	compound	_	_
26	kinases	kinase	NNS	NNS	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	requires	require	VBZ	VBZ	_	23	conj	_	_
29	MAPK	mapk	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	28	dobj	_	_
31	;	;	:	:	_	23	punct	_	_
32	but	but	CC	CC	_	23	cc	_	_
33	in	in	IN	IN	_	39	case	_	_
34	contrast	contrast	NN	NN	_	39	dep	_	_
35	to	to	TO	TO	_	39	case	_	_
36	other	other	JJ	JJ	_	39	amod	_	_
37	tyrosine	tyrosine	NN	NN	_	39	compound	_	_
38	kinase	kinase	NN	NN	_	39	compound	_	_
39	receptors	receptor	NNS	NNS	_	46	nmod	_	_
40	,	,	,	,	_	46	punct	_	_
41	FcR-mediated	fcr-mediated	JJ	JJ	_	43	amod	_	_
42	MAPK	mapk	NN	NN	_	43	compound	_	_
43	activation	activation	NN	NN	_	46	nsubj	_	_
44	does	do	VBZ	VBZ	_	46	aux	_	_
45	not	not	RB	RB	_	46	neg	_	_
46	involve	involve	VB	VB	_	23	conj	_	_
47	Ras	ras	NN	NN	_	46	dobj	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	Raf	raf	NN	NN	_	47	conj	_	_
50	.	.	.	.	_	4	punct	_	_

1	CD4	cd4	NN	NN	_	3	compound	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	transactivation	transactivation	NN	NN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	herpesvirus	herpesvirus	NN	NN	_	3	nmod	_	_
7	6	6	CD	CD	_	6	nummod	_	_
8	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	21	nsubjpass	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	herpesvirus	herpesvirus	NN	NN	_	11	nsubj	_	_
6	6	6	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HHV-6	hhv-6	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	induce	induce	VB	VB	_	2	ccomp	_	_
12	CD4	cd4	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	11	dobj	_	_
14	transcription	transcription	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	expression	expression	NN	NN	_	14	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	CD4(-)	cd4(-)	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	reported	report	VBN	VBN	_	0	root	_	_
22	several	several	JJ	JJ	_	23	amod	_	_
23	years	year	NNS	NNS	_	24	nmod:npmod	_	_
24	ago	ago	RB	RB	_	21	advmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	P.Lusso	P.Lusso	NNP	NNP	_	21	dep	_	_
27	,	,	,	,	_	26	punct	_	_
28	A.De	A.De	NNP	NNP	_	29	compound	_	_
29	Maria	Maria	NNP	NNP	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	M.Malnati	M.Malnati	NNP	NNP	_	26	conj	_	_
32	,	,	,	,	_	26	punct	_	_
33	F.Lori	F.Lori	NNP	NNP	_	26	conj	_	_
34	,	,	,	,	_	26	punct	_	_
35	S.E.DeRocco	S.E.DeRocco	NNP	NNP	_	26	conj	_	_
36	,	,	,	,	_	26	punct	_	_
37	M.	M.	NNP	NNP	_	38	compound	_	_
38	Baseler	Baseler	NNP	NNP	_	26	conj	_	_
39	,	,	,	,	_	26	punct	_	_
40	and	and	CC	CC	_	26	cc	_	_
41	R.C.Gallo	R.C.Gallo	NNP	NNP	_	26	conj	_	_
42	,	,	,	,	_	26	punct	_	_
43	Nature	Nature	NNP	NNP	_	26	dep	_	_
44	349	349	CD	CD	_	43	nummod	_	_
45	:	:	:	:	_	43	punct	_	_
46	533-535	533-535	CD	CD	_	43	dep	_	_
47	,	,	,	,	_	26	punct	_	_
48	1991	1991	CD	CD	_	26	dep	_	_
49	)	)	-RRB-	-RRB-	_	26	punct	_	_
50	and	and	CC	CC	_	21	cc	_	_
51	subsequently	subsequently	RB	RB	_	52	advmod	_	_
52	confirmed	confirm	VBN	VBN	_	21	conj	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	P.Lusso	P.Lusso	NNP	NNP	_	52	dep	_	_
55	,	,	,	,	_	54	punct	_	_
56	M.S.Malnati	M.S.Malnati	NNP	NNP	_	54	conj	_	_
57	,	,	,	,	_	54	punct	_	_
58	A.Garzino-Demo	A.Garzino-Demo	NNP	NNP	_	54	conj	_	_
59	,	,	,	,	_	54	punct	_	_
60	R.W.Crowley	R.W.Crowley	NNP	NNP	_	54	conj	_	_
61	,	,	,	,	_	54	punct	_	_
62	E.	E.	NNP	NNP	_	63	compound	_	_
63	O.Long	O.Long	NNP	NNP	_	54	conj	_	_
64	,	,	,	,	_	54	punct	_	_
65	and	and	CC	CC	_	54	cc	_	_
66	R.C.Gallo	R.C.Gallo	NNP	NNP	_	54	conj	_	_
67	,	,	,	,	_	54	punct	_	_
68	Nature	Nature	NNP	NNP	_	54	appos	_	_
69	362	362	CD	CD	_	68	nummod	_	_
70	:	:	:	:	_	68	punct	_	_
71	458-462	458-462	CD	CD	_	68	dep	_	_
72	,	,	,	,	_	54	punct	_	_
73	1993	1993	CD	CD	_	54	amod	_	_
74	;	;	:	:	_	54	punct	_	_
75	G.Furlini	G.Furlini	NNP	NNP	_	54	dep	_	_
76	,	,	,	,	_	75	punct	_	_
77	M.	M.	NNP	NNP	_	78	compound	_	_
78	Vignoli	Vignoli	NNP	NNP	_	75	conj	_	_
79	,	,	,	,	_	75	punct	_	_
80	E.Ramazzotti	E.Ramazzotti	NNP	NNP	_	75	conj	_	_
81	,	,	,	,	_	75	punct	_	_
82	M.C.Re	M.C.Re	NNP	NNP	_	75	conj	_	_
83	,	,	,	,	_	75	punct	_	_
84	G.Visani	G.Visani	NNP	NNP	_	75	conj	_	_
85	,	,	,	,	_	75	punct	_	_
86	and	and	CC	CC	_	75	cc	_	_
87	M.LaPlaca	M.LaPlaca	NNP	NNP	_	75	conj	_	_
88	,	,	,	,	_	75	punct	_	_
89	Blood	Blood	NNP	NNP	_	75	appos	_	_
90	87	87	CD	CD	_	89	nummod	_	_
91	:	:	:	:	_	89	punct	_	_
92	4737-4745	4737-4745	CD	CD	_	89	dep	_	_
93	,	,	,	,	_	75	punct	_	_
94	1996	1996	CD	CD	_	75	amod	_	_
95	)	)	-RRB-	-RRB-	_	54	punct	_	_
96	.	.	.	.	_	21	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	objective	objective	JJ	JJ	_	3	nsubj	_	_
3	was	be	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	identify	identify	VB	VB	_	3	xcomp	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanisms	mechanism	NNS	NNS	_	5	dobj	_	_
8	underlying	underlie	VBG	VBG	_	7	acl	_	_
9	such	such	JJ	JJ	_	10	amod	_	_
10	phenomena	phenomenon	NNS	NNS	_	8	dobj	_	_
11	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	12	advcl	_	_
2	reporter	reporter	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	constructs	construct	NNS	NNS	_	1	dobj	_	_
5	driven	drive	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CD4	cd4	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	report	report	VBP	VBP	_	0	root	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	HHV-6	hhv-6	NN	NN	_	17	nsubj	_	_
15	can	can	MD	MD	_	17	aux	_	_
16	efficiently	efficiently	RB	RB	_	17	advmod	_	_
17	transactivate	transactivate	VB	VB	_	12	ccomp	_	_
18	such	such	JJ	JJ	_	20	amod	_	_
19	genetic	genetic	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	17	dobj	_	_
21	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CD4	cd4	NN	NN	_	5	compound	_	_
5	promoter	promoter	NN	NN	_	1	nmod	_	_
6	occurs	occur	VBZ	VBZ	_	0	root	_	_
7	in	in	IN	IN	_	17	case	_	_
8	the	the	DT	DT	_	17	dep	_	_
9	presence	presence	NN	NN	_	17	dep	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	viral	viral	JJ	JJ	_	17	amod	_	_
13	DNA	dna	NN	NN	_	17	compound	_	_
14	polymerase	polymerase	NN	NN	_	17	compound	_	_
15	inhibitor	inhibitor	NN	NN	_	17	compound	_	_
16	phosphonoformic	phosphonoformic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	6	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	limits	limit	VBZ	VBZ	_	17	acl:relcl	_	_
21	expression	expression	NN	NN	_	20	dobj	_	_
22	to	to	TO	TO	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	immediate-early	immediate-early	JJ	JJ	_	27	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	early	early	JJ	JJ	_	24	conj	_	_
27	classes	class	NNS	NNS	_	20	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	viral	viral	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	1	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	specific	specific	JJ	JJ	_	8	amod	_	_
6	CD4	cd4	NN	NN	_	8	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	mutants	mutant	NNS	NNS	_	3	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	identified	identify	VBD	VBD	_	0	root	_	_
12	an	a	DT	DT	_	15	det	_	_
13	ATF/CRE	atf/cre	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	11	dobj	_	_
16	located	located	JJ	JJ	_	15	amod	_	_
17	at	at	IN	IN	_	18	case	_	_
18	nucleotides	nucleotide	NNS	NNS	_	16	nmod	_	_
19	-67	-67	CD	CD	_	18	dep	_	_
20	to	to	TO	TO	_	19	dep	_	_
21	-60	-60	CD	CD	_	19	dep	_	_
22	upstream	upstream	JJ	JJ	_	18	advmod	_	_
23	of	of	IN	IN	_	29	case	_	_
24	the	the	DT	DT	_	29	det	_	_
25	CD4	cd4	NN	NN	_	29	compound	_	_
26	gene	gene	NN	NN	_	29	compound	_	_
27	transcription	transcription	NN	NN	_	29	compound	_	_
28	start	start	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	22	nmod	_	_
30	that	that	WDT	WDT	_	32	nsubj	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	important	important	JJ	JJ	_	29	acl:relcl	_	_
33	for	for	IN	IN	_	35	case	_	_
34	HHV-6	hhv-6	NN	NN	_	35	compound	_	_
35	transactivation	transactivation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	ATF/CRE	atf/cre	NN	NN	_	3	compound	_	_
3	site	site	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	essential	essential	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	CD4	cd4	NN	NN	_	10	compound	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	forskolin	forskolin	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	an	a	DT	DT	_	15	det	_	_
15	activator	activator	NN	NN	_	12	appos	_	_
16	of	of	IN	IN	_	18	case	_	_
17	adenylate	adenylate	NN	NN	_	18	compound	_	_
18	cyclase	cyclase	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	antibodies	antibody	NNS	NNS	_	5	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	CREB-1	creb-1	NN	NN	_	14	nsubj	_	_
14	binds	bind	VBZ	VBZ	_	11	ccomp	_	_
15	specifically	specifically	RB	RB	_	14	advmod	_	_
16	to	to	TO	TO	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	-79	-79	CD	CD	_	21	nummod	_	_
19	to	to	TO	TO	_	21	dep	_	_
20	-52	-52	CD	CD	_	21	nummod	_	_
21	region	region	NN	NN	_	14	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	CD4	cd4	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Last	last	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	open	open	JJ	JJ	_	9	amod	_	_
8	reading	reading	NN	NN	_	9	compound	_	_
9	frames	frame	NNS	NNS	_	5	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	ORFs	orf	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	of	of	IN	IN	_	14	case	_	_
14	HHV-6	hhv-6	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	U86	u86	NN	NN	_	9	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	U89	u89	NN	NN	_	16	conj	_	_
19	from	from	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	immediate-early	immediate-early	JJ	JJ	_	23	amod	_	_
22	locus	locus	NN	NN	_	23	compound	_	_
23	A	a	NN	NN	_	5	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	can	can	MD	MD	_	27	aux	_	_
27	transactivate	transactivate	VB	VB	_	23	acl:relcl	_	_
28	the	the	DT	DT	_	30	det	_	_
29	CD4	cd4	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	HeLa	hela	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	transactivation	transactivation	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CD4	cd4	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	ORFs	orf	NNS	NNS	_	3	nmod	_	_
10	U86	u86	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	U89	u89	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	independent	independent	JJ	JJ	_	0	root	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CRE	cre	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	additional	additional	JJ	JJ	_	24	amod	_	_
23	HHV-6	hhv-6	NN	NN	_	24	compound	_	_
24	ORFs	orf	NNS	NNS	_	26	nsubj	_	_
25	are	be	VBP	VBP	_	26	cop	_	_
26	likely	likely	JJ	JJ	_	20	ccomp	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	contribute	contribute	VB	VB	_	26	xcomp	_	_
29	to	to	TO	TO	_	32	case	_	_
30	CD4	cd4	NN	NN	_	32	compound	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Taken	take	VBN	VBN	_	7	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	7	nsubj	_	_
6	will	will	MD	MD	_	7	aux	_	_
7	help	help	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	understand	understand	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	complex	complex	JJ	JJ	_	12	amod	_	_
12	interactions	interaction	NNS	NNS	_	9	dobj	_	_
13	occurring	occur	VBG	VBG	_	12	acl	_	_
14	between	between	IN	IN	_	15	case	_	_
15	HHV-6	hhv-6	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	CD4	cd4	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	conj	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	provide	provide	VB	VB	_	9	conj	_	_
22	additional	additional	JJ	JJ	_	23	amod	_	_
23	information	information	NN	NN	_	21	dobj	_	_
24	regarding	regard	VBG	VBG	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	class	class	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	26	nmod	_	_
30	involved	involve	VBN	VBN	_	26	acl	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	control	control	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	CD4	cd4	NN	NN	_	37	compound	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	suppressor	suppressor	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	0	root	_	_
4	as	as	IN	IN	_	5	case	_	_
5	regulators	regulator	NNS	NNS	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	products	product	NNS	NNS	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	suppressor	suppressor	NN	NN	_	7	compound	_	_
7	genes	gene	NNS	NNS	_	2	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	considered	consider	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	function	function	VB	VB	_	9	xcomp	_	_
12	as	as	IN	IN	_	14	case	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	inhibitors	inhibitor	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	tumor	tumor	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	growth	growth	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	communication	communication	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	present	present	VBP	VBP	_	0	root	_	_
7	evidence	evidence	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	show	show	VB	VB	_	7	acl	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	these	these	DT	DT	_	12	det	_	_
12	proteins	protein	NNS	NNS	_	13	nsubj	_	_
13	inhibit	inhibit	VBP	VBP	_	9	ccomp	_	_
14	tumor	tumor	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	proliferation	proliferation	NN	NN	_	13	dobj	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	participating	participate	VBG	VBG	_	13	advcl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	tumor	tumor	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	differentiation	differentiation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	ML-1	ml-1	NN	NN	_	6	compound	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	myeloblastic	myeloblastic	JJ	JJ	_	6	amod	_	_
5	leukemia	leukemia	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	11	nsubj	_	_
7	used	use	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	this	this	DT	DT	_	10	det	_	_
10	study	study	NN	NN	_	7	nmod	_	_
11	proliferate	proliferate	VBP	VBP	_	0	root	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	treated	treat	VBN	VBN	_	11	advcl	_	_
14	with	with	IN	IN	_	17	case	_	_
15	insulin-like	insulin-like	JJ	JJ	_	17	amod	_	_
16	growth	growth	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	I	i	CD	CD	_	17	nummod	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	transferrin	transferrin	NN	NN	_	17	conj	_	_
21	but	but	CC	CC	_	11	cc	_	_
22	differentiate	differentiate	VBP	VBP	_	11	conj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	monocytes	monocyte	NNS	NNS	_	22	nmod	_	_
25	when	when	WRB	WRB	_	26	advmod	_	_
26	exposed	expose	VBN	VBN	_	22	advcl	_	_
27	to	to	TO	TO	_	31	case	_	_
28	tumor	tumor	NN	NN	_	31	compound	_	_
29	necrosis	necrosis	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	alpha	alpha	NN	NN	_	26	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	transforming	transform	VBG	VBG	_	36	amod	_	_
34	growth	growth	NN	NN	_	36	compound	_	_
35	factor	factor	NN	NN	_	36	compound	_	_
36	beta1	beta1	NN	NN	_	31	conj	_	_
37	,	,	,	,	_	22	punct	_	_
38	or	or	CC	CC	_	22	cc	_	_
39	to	to	TO	TO	_	41	case	_	_
40	macrophage-like	macrophage-like	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	22	conj	_	_
42	when	when	WRB	WRB	_	43	advmod	_	_
43	treated	treat	VBN	VBN	_	41	advcl	_	_
44	with	with	IN	IN	_	47	case	_	_
45	both	both	DT	DT	_	47	det:predet	_	_
46	these	these	DT	DT	_	47	det	_	_
47	cytokines	cytokine	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	11	punct	_	_

1	Initiation	initiation	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	proliferation	proliferation	NN	NN	_	1	nmod	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	3	cc	_	_
6	of	of	IN	IN	_	7	case	_	_
7	differentiation	differentiation	NN	NN	_	3	conj	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	followed	follow	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	20-	20-	CD	CD	_	14	compound	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	25-fold	25-fold	JJ	JJ	_	15	amod	_	_
15	increase	increase	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	level	level	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	DNA	dna	NN	NN	_	26	compound	_	_
23	polymerase-associated	polymerase-associated	JJ	JJ	_	26	amod	_	_
24	processivity	processivity	NN	NN	_	26	compound	_	_
25	factor	factor	NN	NN	_	26	compound	_	_
26	PCNA	pcna	NN	NN	_	19	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	of	of	IN	IN	_	33	case	_	_
29	the	the	DT	DT	_	33	det	_	_
30	proliferation-specific	proliferation-specific	JJ	JJ	_	33	amod	_	_
31	transcription	transcription	NN	NN	_	33	compound	_	_
32	factor	factor	NN	NN	_	33	compound	_	_
33	E2F1	e2f1	NN	NN	_	26	conj	_	_
34	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	induction	induction	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	differentiation	differentiation	NN	NN	_	4	nmod	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	6	cc	_	_
9	of	of	IN	IN	_	10	case	_	_
10	proliferation	proliferation	NN	NN	_	6	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	followed	follow	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	25-	25-	CD	CD	_	17	compound	_	_
16	to	to	TO	TO	_	17	dep	_	_
17	30-fold	30-fold	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	12	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	suppressor	suppressor	NN	NN	_	27	compound	_	_
27	proteins	protein	NNS	NNS	_	22	nmod	_	_
28	p53	p53	NN	NN	_	27	dep	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	wild	wild	JJ	JJ	_	31	amod	_	_
31	type	type	NN	NN	_	28	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	28	punct	_	_
34	pRb	prb	NN	NN	_	28	conj	_	_
35	,	,	,	,	_	28	punct	_	_
36	and	and	CC	CC	_	28	cc	_	_
37	p130/Rb2	p130/rb2	NN	NN	_	28	conj	_	_
38	and	and	CC	CC	_	27	cc	_	_
39	of	of	IN	IN	_	45	case	_	_
40	the	the	DT	DT	_	45	det	_	_
41	p53-dependent	p53-dependent	JJ	JJ	_	45	amod	_	_
42	cyclin	cyclin	NN	NN	_	45	compound	_	_
43	kinase	kinase	NN	NN	_	45	compound	_	_
44	inhibitor	inhibitor	NN	NN	_	45	compound	_	_
45	p21/Cip1	p21/cip1	NN	NN	_	27	conj	_	_
46	.	.	.	.	_	12	punct	_	_

1	p53	p53	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p21/Cip1	p21/cip1	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	7	punct	_	_
5	respectively	respectively	RB	RB	_	7	advmod	_	_
6	,	,	,	,	_	7	punct	_	_
7	inhibit	inhibit	VBP	VBP	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activation	activation	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PCNA	pcna	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	whereas	whereas	IN	IN	_	22	mark	_	_
16	p130	p130	NN	NN	_	22	nsubj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	pRb	prb	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	22	punct	_	_
20	respectively	respectively	RB	RB	_	22	advmod	_	_
21	,	,	,	,	_	22	punct	_	_
22	inhibit	inhibit	VBP	VBP	_	7	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	activation	activation	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	E2F1	e2f1	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	result	result	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	G1-S-associated	g1-s-associated	JJ	JJ	_	6	amod	_	_
6	DNA	dna	NN	NN	_	11	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	synthesis	synthesis	NN	NN	_	6	conj	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	growth	growth	NN	NN	_	14	nsubj	_	_
14	uncoupled	uncouple	VBD	VBD	_	11	ccomp	_	_
15	from	from	IN	IN	_	16	case	_	_
16	differentiation	differentiation	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	maturation	maturation	NN	NN	_	20	nsubj	_	_
20	enabled	enable	VBD	VBD	_	11	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	proceed	proceed	VB	VB	_	20	xcomp	_	_
23	.	.	.	.	_	11	punct	_	_

1	Where	where	WRB	WRB	_	10	advmod	_	_
2	this	this	DT	DT	_	3	det	_	_
3	function	function	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	tumor	tumor	NN	NN	_	8	compound	_	_
7	suppressor	suppressor	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	aux	_	_
10	impaired	impaired	JJ	JJ	_	17	advcl	_	_
11	,	,	,	,	_	17	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	capacity	capacity	NN	NN	_	17	nsubj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	13	nmod	_	_
16	is	be	VBZ	VBZ	_	17	aux	_	_
17	lost	lose	VBN	VBN	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	leads	lead	VBZ	VBZ	_	17	ccomp	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	sustained	sustained	JJ	JJ	_	24	amod	_	_
24	proliferation	proliferation	NN	NN	_	20	nmod	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	characteristic	characteristic	JJ	JJ	_	24	acl:relcl	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	cancer	cancer	NN	NN	_	31	compound	_	_
31	cell	cell	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	17	punct	_	_

1	musculin	musculin	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	9	det	_	_
4	murine	murine	JJ	JJ	_	9	amod	_	_
5	basic	basic	JJ	JJ	_	9	amod	_	_
6	helix-loop-helix	helix-loop-helix	JJ	JJ	_	9	amod	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	1	dep	_	_
10	expressed	express	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	embryonic	embryonic	JJ	JJ	_	14	amod	_	_
13	skeletal	skeletal	JJ	JJ	_	14	amod	_	_
14	muscle	muscle	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	embryonic	embryonic	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	musculin	musculin	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	12	det	_	_
10	new	new	JJ	JJ	_	12	amod	_	_
11	murine	murine	JJ	JJ	_	12	amod	_	_
12	member	member	NN	NN	_	7	appos	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	bHLH	bhlh	JJ	JJ	_	16	amod	_	_
16	family	family	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Musculin	musculin	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	closely	closely	RB	RB	_	5	advmod	_	_
5	related	related	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	ABF-1	abf-1	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	8	acl:relcl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	to	to	TO	TO	_	20	case	_	_
20	epicardin/capsulin/Pod-1	epicardin/capsulin/pod-1	NN	NN	_	8	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	expressed	express	VBN	VBN	_	20	acl:relcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	branchial	branchial	JJ	JJ	_	27	amod	_	_
27	myoblasts	myoblast	NNS	NNS	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	visceral	visceral	JJ	JJ	_	32	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	urogenital	urogenital	JJ	JJ	_	29	conj	_	_
32	mesoderm	mesoderm	NN	NN	_	27	appos	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	epicardium	epicardium	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	5	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	hybridisation	hybridisation	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	musculin	musculin	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	11	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	embryos	embryo	NNS	NNS	_	6	nmod	_	_
9	was	be	VBD	VBD	_	11	aux	_	_
10	largely	largely	RB	RB	_	11	advmod	_	_
11	restricted	restricted	JJ	JJ	_	4	ccomp	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	embryonic	embryonic	JJ	JJ	_	17	amod	_	_
15	skeletal	skeletal	JJ	JJ	_	17	amod	_	_
16	muscle	muscle	NN	NN	_	17	compound	_	_
17	lineage	lineage	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	all	all	DT	DT	_	4	det	_	_
3	skeletal	skeletal	JJ	JJ	_	4	amod	_	_
4	muscles	muscle	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	18	advcl	_	_
6	the	the	DT	DT	_	7	det	_	_
7	gene	gene	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	18	punct	_	_
9	only	only	RB	RB	_	11	advmod	_	_
10	a	a	DT	DT	_	11	det	_	_
11	subset	subset	NN	NN	_	18	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	myocytes	myocyte	NNS	NNS	_	11	nmod	_	_
14	within	within	IN	IN	_	16	case	_	_
15	each	each	DT	DT	_	16	det	_	_
16	muscle	muscle	NN	NN	_	13	nmod	_	_
17	were	be	VBD	VBD	_	18	cop	_	_
18	positive	positive	JJ	JJ	_	0	root	_	_
19	,	,	,	,	_	18	punct	_	_
20	indicating	indicate	VBG	VBG	_	18	xcomp	_	_
21	molecular	molecular	JJ	JJ	_	22	amod	_	_
22	heterogeneity	heterogeneity	NN	NN	_	20	dobj	_	_
23	within	within	IN	IN	_	25	case	_	_
24	fetal	fetal	JJ	JJ	_	25	amod	_	_
25	muscle	muscle	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	18	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Elsevier	Elsevier	NNP	NNP	_	6	compound	_	_
4	Science	Science	NNP	NNP	_	6	compound	_	_
5	Ireland	Ireland	NNP	NNP	_	6	compound	_	_
6	Ltd	Ltd	NNP	NNP	_	2	dep	_	_
7	.	.	.	.	_	2	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	Rights	rights	NNS	NNS	_	3	nsubj	_	_
3	Reserved	reserve	VBN	VBN	_	0	root	_	_
4	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	signaling	signaling	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	extrinsic	extrinsic	JJ	JJ	_	9	amod	_	_
9	asthma	asthma	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	hyperimmunoglobulin	hyperimmunoglobulin	NN	NN	_	12	compound	_	_
12	E	e	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Recent	recent	JJ	JJ	_	4	amod	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	appos	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	17	nsubjpass	_	_
9	of	of	IN	IN	_	11	case	_	_
10	class	class	NN	NN	_	11	compound	_	_
11	switching	switching	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	IgE	ige	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	5	ccomp	_	_
18	by	by	IN	IN	_	21	case	_	_
19	STAT	stat	NN	NN	_	21	compound	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IgE	ige	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-13	il-13	NN	NN	_	6	conj	_	_
9	occurs	occur	VBZ	VBZ	_	0	root	_	_
10	through	through	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
16	signal-transducing	signal-transducing	JJ	JJ	_	18	amod	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	Stat6	stat6	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	whereas	whereas	IN	IN	_	9	dep	_	_
21	the	the	DT	DT	_	22	det	_	_
22	inhibition	inhibition	NN	NN	_	32	nsubj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	IgE	ige	NN	NN	_	26	compound	_	_
25	class	class	NN	NN	_	26	compound	_	_
26	switching	switching	NN	NN	_	22	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	interferon-y	interferon-y	NN	NN	_	22	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	IFN-gamma	ifn-gamma	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	occurs	occur	VBZ	VBZ	_	9	parataxis	_	_
33	through	through	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	activation	activation	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	Statl	statl	NN	NN	_	35	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	hypothesized	hypothesize	VBD	VBD	_	1	appos	_	_
5	that	that	IN	IN	_	31	mark	_	_
6	in	in	IN	IN	_	8	case	_	_
7	extrinsic	extrinsic	JJ	JJ	_	8	amod	_	_
8	asthma	asthma	NN	NN	_	31	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cases	case	NNS	NNS	_	8	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	markedly	markedly	RB	RB	_	14	advmod	_	_
14	elevated	elevated	JJ	JJ	_	15	amod	_	_
15	IgE	ige	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	ie	ie	NN	NN	_	20	advmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	hyperimmunoglobulin	hyperimmunoglobulin	NN	NN	_	20	compound	_	_
20	E	e	NN	NN	_	15	dep	_	_
21	-LSB-	-lsb-	-LRB-	-LRB-	_	22	punct	_	_
22	HIE	hie	NN	NN	_	20	appos	_	_
23	-RSB-	-rsb-	-RRB-	-RRB-	_	22	punct	_	_
24	)	)	-RRB-	-RRB-	_	20	punct	_	_
25	increased	increase	VBN	VBN	_	26	amod	_	_
26	levels	level	NNS	NNS	_	31	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IgE	ige	NN	NN	_	26	nmod	_	_
29	may	may	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	associated	associate	VBN	VBN	_	4	ccomp	_	_
32	with	with	IN	IN	_	33	case	_	_
33	alterations	alteration	NNS	NNS	_	31	nmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	cytokine	cytokine	NN	NN	_	37	compound	_	_
37	levels	level	NNS	NNS	_	33	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	the	the	DT	DT	_	40	det	_	_
40	activation	activation	NN	NN	_	37	conj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	Stat6	stat6	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	PBMCs	pbmc	NNS	NNS	_	45	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	sera	serum	NNS	NNS	_	3	conj	_	_
6	from	from	IN	IN	_	8	case	_	_
7	8	8	CD	CD	_	8	nummod	_	_
8	patients	patient	NNS	NNS	_	3	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	extrinsic	extrinsic	JJ	JJ	_	11	amod	_	_
11	asthma	asthma	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	mean	mean	JJ	JJ	_	14	amod	_	_
14	IgE	ige	NN	NN	_	17	dep	_	_
15	,	,	,	,	_	17	punct	_	_
16	285+/-100	285+/-100	CD	CD	_	17	nummod	_	_
17	IU/mL	iu/ml	NN	NN	_	8	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	8	punct	_	_
20	3	3	CD	CD	_	21	nummod	_	_
21	patients	patient	NNS	NNS	_	8	conj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	HIE	hie	NN	NN	_	21	nmod	_	_
24	(	(	-LRB-	-LRB-	_	29	punct	_	_
25	mean	mean	JJ	JJ	_	26	amod	_	_
26	IgE	ige	NN	NN	_	29	dep	_	_
27	,	,	,	,	_	29	punct	_	_
28	7050+/-1122	7050+/-1122	CD	CD	_	29	nummod	_	_
29	IU/mL	iu/ml	NN	NN	_	21	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	8	punct	_	_
32	and	and	CC	CC	_	8	cc	_	_
33	14	14	CD	CD	_	36	nummod	_	_
34	nonatopic	nonatopic	JJ	JJ	_	36	amod	_	_
35	control	control	JJ	JJ	_	36	amod	_	_
36	subjects	subject	NNS	NNS	_	8	conj	_	_
37	(	(	-LRB-	-LRB-	_	42	punct	_	_
38	mean	mean	JJ	JJ	_	39	amod	_	_
39	IgE	ige	NN	NN	_	42	dep	_	_
40	,	,	,	,	_	42	punct	_	_
41	112+/-28	112+/-28	CD	CD	_	42	nummod	_	_
42	IU/mL	iu/ml	NN	NN	_	36	dep	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	were	be	VBD	VBD	_	45	auxpass	_	_
45	analyzed	analyze	VBN	VBN	_	1	appos	_	_
46	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	mean	mean	JJ	JJ	_	6	amod	_	_
5	IL-4	il-4	NN	NN	_	6	compound	_	_
6	level	level	NN	NN	_	12	nsubj	_	_
7	detected	detect	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	ELISA	elisa	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	much	much	RB	RB	_	12	advmod	_	_
12	greater	greater	JJR	JJR	_	1	appos	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	HIE	hie	NN	NN	_	14	nmod	_	_
17	than	than	IN	IN	_	19	case	_	_
18	control	control	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	12	nmod	_	_
20	(	(	-LRB-	-LRB-	_	28	punct	_	_
21	88.6+/-11.5	88.6+/-11.5	CD	CD	_	22	nummod	_	_
22	pg/mL	pg/ml	NN	NN	_	28	dep	_	_
23	vs	vs	CC	CC	_	22	cc	_	_
24	11.5+/-7.1	11.5+/-7.1	CD	CD	_	25	nummod	_	_
25	pg/mL	pg/ml	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	28	punct	_	_
27	P	p	NN	NN	_	28	nsubj	_	_
28	=	=	JJ	JJ	_	12	parataxis	_	_
29	.005	.005	NN	NN	_	28	dobj	_	_
30	)	)	-RRB-	-RRB-	_	28	punct	_	_
31	,	,	,	,	_	12	punct	_	_
32	and	and	CC	CC	_	12	cc	_	_
33	increased	increase	VBN	VBN	_	35	amod	_	_
34	IL-4	il-4	NN	NN	_	35	compound	_	_
35	levels	level	NNS	NNS	_	12	conj	_	_
36	among	among	IN	IN	_	37	case	_	_
37	patients	patient	NNS	NNS	_	35	nmod	_	_
38	with	with	IN	IN	_	40	case	_	_
39	both	both	CC	CC	_	40	cc:preconj	_	_
40	asthma	asthma	NN	NN	_	37	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	HIE	hie	NN	NN	_	40	conj	_	_
43	correlated	correlate	VBD	VBD	_	48	dep	_	_
44	with	with	IN	IN	_	48	case	_	_
45	the	the	DT	DT	_	48	det	_	_
46	increased	increase	VBN	VBN	_	48	amod	_	_
47	IgE	ige	NN	NN	_	48	compound	_	_
48	levels	level	NNS	NNS	_	35	advcl	_	_
49	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	IL-13	il-13	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	8	nsubj	_	_
6	were	be	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	elevated	elevated	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Levels	level	NNS	NNS	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Stat6	stat6	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	1	nmod	_	_
5	present	present	JJ	JJ	_	4	amod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	PBMCs	pbmc	NNS	NNS	_	5	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	differ	differ	VB	VB	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	patients	patient	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	control	control	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	10	punct	_	_

1	Examination	examination	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Stat6	stat6	NN	NN	_	5	compound	_	_
4	DNA-binding	dna-binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IL-4	il-4	NN	NN	_	11	compound	_	_
11	signaling	signaling	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	6	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	either	either	CC	CC	_	16	cc:preconj	_	_
16	HIE	hie	NN	NN	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	acute	acute	JJ	JJ	_	19	amod	_	_
19	asthma	asthma	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Interestingly	interestingly	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	evidence	evidence	NN	NN	_	17	nsubjpass	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	13	nsubj	_	_
11	have	have	VBP	VBP	_	13	aux	_	_
12	already	already	RB	RB	_	13	advmod	_	_
13	switched	switch	VBN	VBN	_	9	acl:relcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	IgE	ige	NN	NN	_	13	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	seen	see	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	PBMCs	pbmc	NNS	NNS	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	patients	patient	NNS	NNS	_	19	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	asthma	asthma	NN	NN	_	22	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	HIE	hie	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	17	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	5	dep	_	_
2	:	:	:	:	_	5	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	1	1	LS	LS	_	18	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	IgE	ige	NN	NN	_	11	compound	_	_
11	production	production	NN	NN	_	18	nsubjpass	_	_
12	in	in	IN	IN	_	13	case	_	_
13	asthma	asthma	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HIE	hie	NN	NN	_	13	conj	_	_
16	usually	usually	RB	RB	_	18	advmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	associated	associate	VBN	VBN	_	5	ccomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	elevated	elevated	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-4	il-4	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	but	but	CC	CC	_	26	cc	_	_
26	not	not	RB	RB	_	23	cc	_	_
27	IL-13	il-13	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
32	blood	blood	NN	NN	_	21	nmod	_	_
33	;	;	:	:	_	18	punct	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	2	2	LS	LS	_	48	dep	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	the	the	DT	DT	_	41	det	_	_
38	increased	increase	VBN	VBN	_	41	amod	_	_
39	sera	serum	NNS	NNS	_	41	compound	_	_
40	IL-4	il-4	NN	NN	_	41	compound	_	_
41	levels	level	NNS	NNS	_	48	nsubj	_	_
42	in	in	IN	IN	_	43	case	_	_
43	asthma	asthma	NN	NN	_	41	nmod	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	HIE	hie	NN	NN	_	43	conj	_	_
46	are	be	VBP	VBP	_	48	cop	_	_
47	not	not	RB	RB	_	48	neg	_	_
48	sufficient	sufficient	JJ	JJ	_	18	conj	_	_
49	to	to	TO	TO	_	50	mark	_	_
50	induce	induce	VB	VB	_	48	xcomp	_	_
51	Stat6	stat6	NN	NN	_	52	compound	_	_
52	activation	activation	NN	NN	_	50	dobj	_	_
53	in	in	IN	IN	_	54	case	_	_
54	PBMCs	pbmc	NNS	NNS	_	52	nmod	_	_
55	;	;	:	:	_	18	punct	_	_
56	and	and	CC	CC	_	18	cc	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	3	3	LS	LS	_	68	dep	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	evidence	evidence	NN	NN	_	68	nsubjpass	_	_
61	of	of	IN	IN	_	63	case	_	_
62	switch	switch	NN	NN	_	63	compound	_	_
63	recombination	recombination	NN	NN	_	60	nmod	_	_
64	to	to	TO	TO	_	65	case	_	_
65	epsilon	epsilon	NN	NN	_	63	nmod	_	_
66	may	may	MD	MD	_	68	aux	_	_
67	be	be	VB	VB	_	68	auxpass	_	_
68	detected	detect	VBN	VBN	_	18	conj	_	_
69	in	in	IN	IN	_	71	case	_	_
70	isolated	isolate	VBN	VBN	_	71	amod	_	_
71	cases	case	NNS	NNS	_	68	nmod	_	_
72	of	of	IN	IN	_	74	case	_	_
73	elevated	elevated	JJ	JJ	_	74	amod	_	_
74	IgE	ige	NN	NN	_	71	nmod	_	_
75	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	implies	imply	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IgE	ige	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	patients	patient	NNS	NNS	_	7	nmod	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	results	result	VBZ	VBZ	_	2	ccomp	_	_
13	from	from	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	19	nsubj	_	_
17	have	have	VBP	VBP	_	19	aux	_	_
18	already	already	RB	RB	_	19	advmod	_	_
19	undergone	undergo	VBN	VBN	_	15	acl:relcl	_	_
20	class	class	NN	NN	_	21	compound	_	_
21	switching	switching	NN	NN	_	19	dobj	_	_
22	,	,	,	,	_	12	punct	_	_
23	from	from	IN	IN	_	26	case	_	_
24	Ig	ig	NN	NN	_	26	compound	_	_
25	class	class	NN	NN	_	26	compound	_	_
26	switching	switching	NN	NN	_	12	dep	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	is	be	VBZ	VBZ	_	29	aux	_	_
29	localized	localized	JJ	JJ	_	26	acl:relcl	_	_
30	to	to	TO	TO	_	32	case	_	_
31	target	target	NN	NN	_	32	compound	_	_
32	tissues	tissue	NNS	NNS	_	29	nmod	_	_
33	,	,	,	,	_	12	punct	_	_
34	or	or	CC	CC	_	12	cc	_	_
35	both	both	DT	DT	_	12	conj	_	_
36	.	.	.	.	_	2	punct	_	_

1	Cross-priming	cross-priming	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CTL	ctl	NN	NN	_	4	compound	_	_
4	responses	response	NNS	NNS	_	1	nmod	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vivo	vivo	FW	FW	_	1	advmod	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	require	require	VB	VB	_	0	root	_	_
10	antigenic	antigenic	JJ	JJ	_	11	amod	_	_
11	peptides	peptide	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	endoplasmic	endoplasmic	JJ	JJ	_	15	amod	_	_
15	reticulum	reticulum	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	immunizing	immunizing	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	proposed	propose	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	cross-priming	cross-priming	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CTL	ctl	NN	NN	_	10	compound	_	_
10	responses	response	NNS	NNS	_	7	nmod	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vivo	vivo	FW	FW	_	7	advmod	_	_
13	involves	involve	VBZ	VBZ	_	4	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	transfer	transfer	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	host	host	NN	NN	_	18	compound	_	_
18	APCs	apc	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	26	case	_	_
20	heat	heat	NN	NN	_	24	nmod:npmod	_	_
21	shock	shock	NN	NN	_	24	nmod:npmod	_	_
22	protein	protein	NN	NN	_	24	nmod:npmod	_	_
23	glycoprotein	glycoprotein	NN	NN	_	24	nmod:npmod	_	_
24	96-chaperoned	96-chaperoned	JJ	JJ	_	26	amod	_	_
25	antigenic	antigenic	JJ	JJ	_	26	amod	_	_
26	peptides	peptide	NNS	NNS	_	18	nmod	_	_
27	released	release	VBN	VBN	_	26	acl	_	_
28	from	from	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	endoplasmic	endoplasmic	JJ	JJ	_	31	amod	_	_
31	reticulum	reticulum	NN	NN	_	27	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ER	er	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	of	of	IN	IN	_	39	case	_	_
36	dying	die	VBG	VBG	_	39	amod	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	infected	infected	JJ	JJ	_	36	conj	_	_
39	cells	cell	NNS	NNS	_	31	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	tested	test	VBN	VBN	_	0	root	_	_
4	this	this	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	directly	directly	RB	RB	_	7	advmod	_	_
7	using	use	VBG	VBG	_	3	xcomp	_	_
8	TAP-deficient	tap-deficient	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	7	dobj	_	_
11	lacking	lack	VBG	VBG	_	10	acl	_	_
12	antigenic	antigenic	JJ	JJ	_	14	amod	_	_
13	ER	er	NN	NN	_	14	compound	_	_
14	peptides	peptide	NNS	NNS	_	11	dobj	_	_
15	derived	derive	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	19	case	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	model	model	NN	NN	_	19	compound	_	_
19	Ags	ag	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	the	the	DT	DT	_	27	det	_	_
22	human	human	JJ	JJ	_	27	amod	_	_
23	adenovirus	adenovirus	NN	NN	_	27	compound	_	_
24	type	type	NN	NN	_	27	compound	_	_
25	5	5	CD	CD	_	27	nummod	_	_
26	early	early	JJ	JJ	_	27	amod	_	_
27	regions	region	NNS	NNS	_	19	appos	_	_
28	E1A	e1a	NN	NN	_	27	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	E1B	e1b	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	both	both	DT	DT	_	3	det	_	_
3	proteins	protein	NNS	NNS	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	well	well	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	12	advcl	_	_
7	,	,	,	,	_	12	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	recognized	recognize	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	E1A-	e1a-	NN	NN	_	17	amod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	E1B-specific	e1b-specific	JJ	JJ	_	14	conj	_	_
17	CTLs	ctl	NNS	NNS	_	12	nmod	_	_
18	unless	unless	IN	IN	_	24	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	relevant	relevant	JJ	JJ	_	21	amod	_	_
21	epitope	epitope	NN	NN	_	24	nsubjpass	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	either	either	CC	CC	_	24	cc:preconj	_	_
24	provided	provide	VBN	VBN	_	12	advcl	_	_
25	exogenously	exogenously	RB	RB	_	24	advmod	_	_
26	as	as	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	synthetic	synthetic	JJ	JJ	_	29	amod	_	_
29	peptide	peptide	NN	NN	_	24	nmod	_	_
30	or	or	CC	CC	_	24	cc	_	_
31	targeted	target	VBN	VBN	_	24	conj	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	ER	er	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	a	a	DT	DT	_	38	det	_	_
37	TAP-independent	tap-independent	JJ	JJ	_	38	amod	_	_
38	fashion	fashion	NN	NN	_	31	nmod	_	_
39	.	.	.	.	_	12	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	13	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	these	these	DT	DT	_	7	det	_	_
6	ER	er	NN	NN	_	7	compound	_	_
7	peptides	peptide	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	TAP1-/-	tap1-/-	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	13	nsubj	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	able	able	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	efficiently	efficiently	RB	RB	_	16	advmod	_	_
16	cross-prime	cross-prime	VB	VB	_	13	xcomp	_	_
17	E1A-	e1a-	NN	NN	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	E1B-specific	e1b-specific	JJ	JJ	_	17	conj	_	_
20	CTLs	ctl	NNS	NNS	_	16	dobj	_	_
21	following	follow	VBG	VBG	_	22	case	_	_
22	immunization	immunization	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	syngeneic	syngeneic	JJ	JJ	_	25	amod	_	_
25	mice	mouse	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	,	,	,	,	_	24	punct	_	_
6	although	although	IN	IN	_	13	mark	_	_
7	purified	purify	VBN	VBN	_	10	amod	_	_
8	peptide/glycoprotein	peptide/glycoprotein	NN	NN	_	10	compound	_	_
9	96	96	CD	CD	_	10	nummod	_	_
10	complexes	complex	NNS	NNS	_	13	nsubj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	potent	potent	JJ	JJ	_	13	amod	_	_
13	immunogens	immunogen	NNS	NNS	_	24	advcl	_	_
14	,	,	,	,	_	24	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mechanism	mechanism	NN	NN	_	24	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	CTL	ctl	NN	NN	_	19	compound	_	_
19	cross-priming	cross-priming	NN	NN	_	16	nmod	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	19	advmod	_	_
22	does	do	VBZ	VBZ	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	depend	depend	VB	VB	_	3	ccomp	_	_
25	upon	upon	IN	IN	_	27	case	_	_
26	antigenic	antigenic	JJ	JJ	_	27	amod	_	_
27	peptides	peptide	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	ER	er	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	immunizing	immunizing	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	responsiveness	responsiveness	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	IL-5	il-5	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-4	il-4	NN	NN	_	5	conj	_	_
8	genes	gene	NNS	NNS	_	2	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	GATA-3	gata-3	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	9	nsubjpass	_	_
3	IL-4	il-4	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-5	il-5	NN	NN	_	3	conj	_	_
6	are	be	VBP	VBP	_	9	auxpass	_	_
7	often	often	RB	RB	_	9	advmod	_	_
8	coordinately	coordinately	RB	RB	_	9	advmod	_	_
9	produced	produce	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	Th2	th2	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	in	in	IN	IN	_	15	case	_	_
15	asthma	asthma	NN	NN	_	12	acl	_	_
16	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	unclear	unclear	JJ	JJ	_	0	root	_	_
6	whether	whether	IN	IN	_	10	mark	_	_
7	similar	similar	JJ	JJ	_	9	amod	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	10	nsubj	_	_
10	underlie	underlie	VBP	VBP	_	5	ccomp	_	_
11	transcription	transcription	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	genes	gene	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	GATA-3	gata-3	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	4	ccomp	_	_
12	in	in	IN	IN	_	17	case	_	_
13	Th2	th2	NN	NN	_	17	compound	_	_
14	but	but	CC	CC	_	13	cc	_	_
15	not	not	RB	RB	_	13	conj	_	_
16	Th1	th1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	crucial	crucial	JJ	JJ	_	11	conj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	activation	activation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IL-5	il-5	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	22	nmod	_	_
27	by	by	IN	IN	_	29	case	_	_
28	different	different	JJ	JJ	_	29	amod	_	_
29	stimuli	stimulus	NNS	NNS	_	22	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	different	different	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	GATA-3	gata-3	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	8	xcomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-4	il-4	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	other	other	JJ	JJ	_	21	amod	_	_
19	Th2	th2	NN	NN	_	21	compound	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	16	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	ectopic	ectopic	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GATA-3	gata-3	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	sufficient	sufficient	JJ	JJ	_	4	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	drive	drive	VB	VB	_	11	xcomp	_	_
14	IL-5	il-5	NN	NN	_	19	compound	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	14	conj	_	_
17	IL-4	il-4	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	13	dobj	_	_
20	.	.	.	.	_	4	punct	_	_

1	Also	also	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	Th2	th2	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	antisense	antisense	JJ	JJ	_	9	amod	_	_
8	GATA-3	gata-3	NN	NN	_	9	compound	_	_
9	RNA	rna	NN	NN	_	10	nsubj	_	_
10	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
11	IL-5	il-5	NN	NN	_	16	compound	_	_
12	but	but	CC	CC	_	11	cc	_	_
13	not	not	RB	RB	_	11	conj	_	_
14	IL-4	il-4	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	10	dobj	_	_
17	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	IL-5	il-5	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	GATA-3	gata-3	NN	NN	_	2	nmod	_	_
9	involves	involve	VBZ	VBZ	_	0	root	_	_
10	high	high	JJ	JJ	_	12	amod	_	_
11	affinity	affinity	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GATA-3	gata-3	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	inverted	inverted	JJ	JJ	_	19	amod	_	_
18	GATA	gata	NN	NN	_	19	compound	_	_
19	repeat	repeat	NN	NN	_	12	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	IL-5	il-5	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	GATA-3-dependent	gata-3-dependent	JJ	JJ	_	3	amod	_	_
2	enhancer	enhancer	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	IL-4	il-4	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	Previously	previously	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	analyzed	analyze	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	proximal	proximal	JJ	JJ	_	8	amod	_	_
7	IL-4	il-4	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	directing	direct	VBG	VBG	_	8	acl	_	_
11	Th2-specific	th2-specific	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	800-base	800-base	JJ	JJ	_	5	amod	_	_
3	pair	pair	NN	NN	_	5	compound	_	_
4	proximal	proximal	JJ	JJ	_	5	amod	_	_
5	promoter	promoter	NN	NN	_	6	nsubj	_	_
6	conferred	confer	VBD	VBD	_	0	root	_	_
7	some	some	DT	DT	_	9	det	_	_
8	Th2-selective	th2-selective	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	transgenic	transgenic	JJ	JJ	_	12	amod	_	_
12	mice	mouse	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	region	region	NN	NN	_	5	nsubj	_	_
5	directed	direct	VBD	VBD	_	0	root	_	_
6	extremely	extremely	RB	RB	_	7	advmod	_	_
7	low	low	JJ	JJ	_	10	amod	_	_
8	reporter	reporter	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	5	dobj	_	_
11	relative	relative	JJ	JJ	_	10	advmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
14	IL-4	il-4	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	full	full	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	22	nsubj	_	_
22	requires	require	VBZ	VBZ	_	17	ccomp	_	_
23	additional	additional	JJ	JJ	_	25	amod	_	_
24	enhancer	enhancer	NN	NN	_	25	compound	_	_
25	elements	element	NNS	NNS	_	22	dobj	_	_
26	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	analyzed	analyze	VBD	VBD	_	0	root	_	_
5	large	large	JJ	JJ	_	8	amod	_	_
6	genomic	genomic	JJ	JJ	_	8	amod	_	_
7	IL-4	il-4	NN	NN	_	8	compound	_	_
8	regions	region	NNS	NNS	_	4	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	enhancer	enhancer	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	interaction	interaction	NN	NN	_	11	conj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	proximal	proximal	JJ	JJ	_	4	amod	_	_
3	IL-4	il-4	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	8	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	8	auxpass	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	moderately	moderately	RB	RB	_	8	advmod	_	_
8	augmented	augment	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	GATA-3	gata-3	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	but	but	CC	CC	_	8	cc	_	_
13	certain	certain	JJ	JJ	_	15	amod	_	_
14	genomic	genomic	JJ	JJ	_	15	amod	_	_
15	regions	region	NNS	NNS	_	17	nsubj	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	enhanced	enhance	VBD	VBD	_	8	conj	_	_
18	GATA-3	gata-3	NN	NN	_	20	compound	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	transactivation	transactivation	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	8	punct	_	_

1	Some	some	DT	DT	_	3	det	_	_
2	enhancing	enhance	VBG	VBG	_	3	amod	_	_
3	regions	region	NNS	NNS	_	4	nsubj	_	_
4	contained	contain	VBD	VBD	_	0	root	_	_
5	consensus	consensus	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	GATA	gata	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	5	appos	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	bound	bind	VBD	VBD	_	8	acl:relcl	_	_
11	Th2-specific	th2-specific	JJ	JJ	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	10	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	retroviral	retroviral	JJ	JJ	_	4	amod	_	_
4	transduction	transduction	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	GATA-3	gata-3	NN	NN	_	4	nmod	_	_
7	into	into	IN	IN	_	10	case	_	_
8	developing	develop	VBG	VBG	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	induced	induce	VBD	VBD	_	0	root	_	_
12	IL-5	il-5	NN	NN	_	11	dobj	_	_
13	to	to	TO	TO	_	16	case	_	_
14	full	full	JJ	JJ	_	16	amod	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	levels	level	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	but	but	CC	CC	_	11	cc	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	partially	partially	RB	RB	_	21	advmod	_	_
21	restored	restore	VBD	VBD	_	11	conj	_	_
22	IL-4	il-4	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	propose	propose	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	GATA-3	gata-3	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	permissive	permissive	JJ	JJ	_	4	ccomp	_	_
9	,	,	,	,	_	8	punct	_	_
10	but	but	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	8	cc	_	_
12	sufficient	sufficient	JJ	JJ	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	for	for	IN	IN	_	17	case	_	_
15	full	full	JJ	JJ	_	17	amod	_	_
16	IL-4	il-4	NN	NN	_	17	compound	_	_
17	enhancement	enhancement	NN	NN	_	8	nmod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	act	act	VB	VB	_	8	conj	_	_
21	through	through	IN	IN	_	23	case	_	_
22	GATA	gata	NN	NN	_	23	compound	_	_
23	elements	element	NNS	NNS	_	20	nmod	_	_
24	surrounding	surround	VBG	VBG	_	23	acl	_	_
25	the	the	DT	DT	_	28	det	_	_
26	IL-13/IL-4	il-13/il-4	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	locus	locus	NN	NN	_	24	dobj	_	_
29	.	.	.	.	_	4	punct	_	_

1	Seminoma	seminoma	NN	NN	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	postmenopausal	postmenopausal	JJ	JJ	_	5	amod	_	_
5	woman	woman	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	Y;15	y;15	NN	NN	_	9	compound	_	_
9	translocation	translocation	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	a	a	DT	DT	_	19	det	_	_
16	t(Y;15)/45,X	t(y;15)/45,x	NN	NN	_	19	compound	_	_
17	Turner	turner	NN	NN	_	19	compound	_	_
18	mosaic	mosaic	JJ	JJ	_	19	amod	_	_
19	pattern	pattern	NN	NN	_	9	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	skin	skin	NN	NN	_	22	compound	_	_
22	fibroblasts	fibroblast	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	unusual	unusual	JJ	JJ	_	5	amod	_	_
5	case	case	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	55	55	CD	CD	_	10	compound	_	_
9	year	year	NN	NN	_	10	nmod:npmod	_	_
10	old	old	JJ	JJ	_	12	amod	_	_
11	Japanese	japanese	NN	NN	_	12	compound	_	_
12	woman	woman	NN	NN	_	5	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	seminoma	seminoma	NN	NN	_	12	nmod	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	relatively	relatively	RB	RB	_	18	advmod	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	menses	menses	NNS	NNS	_	15	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	patient	patient	NN	NN	_	6	nsubj	_	_
3	was	be	VBD	VBD	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	phenotypic	phenotypic	JJ	JJ	_	6	amod	_	_
6	female	female	NN	NN	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	late	late	JJ	JJ	_	10	amod	_	_
9	onset	onset	NN	NN	_	10	compound	_	_
10	menarche	menarche	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	18	18	CD	CD	_	13	nummod	_	_
13	years	year	NNS	NNS	_	10	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	age	age	NN	NN	_	13	nmod	_	_
16	)	)	-RRB-	-RRB-	_	13	punct	_	_
17	,	,	,	,	_	6	punct	_	_
18	who	who	WP	WP	_	20	nsubj	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	amenorrhoeic	amenorrhoeic	JJ	JJ	_	6	acl:relcl	_	_
21	for	for	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	first	first	JJ	JJ	_	24	amod	_	_
24	year	year	NN	NN	_	20	nmod	_	_
25	,	,	,	,	_	20	punct	_	_
26	followed	follow	VBN	VBN	_	20	dep	_	_
27	by	by	IN	IN	_	28	case	_	_
28	menses	menses	NNS	NNS	_	26	nmod	_	_
29	of	of	IN	IN	_	36	case	_	_
30	one	one	CD	CD	_	32	compound	_	_
31	to	to	TO	TO	_	32	dep	_	_
32	three	three	CD	CD	_	33	nummod	_	_
33	days	day	NNS	NNS	_	36	nmod:poss	_	_
34	'	'	POS	POS	_	33	case	_	_
35	slight	slight	JJ	JJ	_	36	amod	_	_
36	flow	flow	NN	NN	_	28	nmod	_	_
37	with	with	IN	IN	_	38	case	_	_
38	dysmenorrhoea	dysmenorrhoea	NN	NN	_	36	nmod	_	_
39	,	,	,	,	_	28	punct	_	_
40	but	but	CC	CC	_	28	cc	_	_
41	an	a	DT	DT	_	45	det	_	_
42	otherwise	otherwise	RB	RB	_	43	advmod	_	_
43	normal	normal	JJ	JJ	_	45	amod	_	_
44	menstrual	menstrual	JJ	JJ	_	45	amod	_	_
45	history	history	NN	NN	_	28	conj	_	_
46	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	typical	typical	JJ	JJ	_	3	amod	_	_
3	seminoma	seminoma	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	removed	remove	VBN	VBN	_	0	root	_	_
6	from	from	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	left	left	JJ	JJ	_	10	amod	_	_
9	adnexal	adnexal	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	an	a	DT	DT	_	14	det	_	_
13	immature	immature	JJ	JJ	_	14	amod	_	_
14	testis	testis	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	5	conj	_	_
17	separately	separately	RB	RB	_	16	advmod	_	_
18	as	as	IN	IN	_	23	case	_	_
19	an	a	DT	DT	_	23	det	_	_
20	associated	associate	VBN	VBN	_	23	amod	_	_
21	right	right	JJ	JJ	_	23	amod	_	_
22	adnexal	adnexal	JJ	JJ	_	23	amod	_	_
23	mass	mass	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Repeated	repeated	JJ	JJ	_	3	amod	_	_
2	karyotypic	karyotypic	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	9	nsubj	_	_
4	on	on	IN	IN	_	8	case	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	8	compound	_	_
8	cultures	culture	NNS	NNS	_	3	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	only	only	RB	RB	_	11	advmod	_	_
11	46,X,-Y,t(Y;15)(q12;p13)	46,x,-y,t(y;15)(q12;p13)	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	Cytogenetic	cytogenetic	JJ	JJ	_	2	amod	_	_
2	examination	examination	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	patient	patient	NN	NN	_	8	nmod:poss	_	_
6	's	's	POS	POS	_	5	case	_	_
7	younger	younger	JJR	JJR	_	8	amod	_	_
8	brother	brother	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	who	who	WP	WP	_	12	nsubj	_	_
11	had	have	VBD	VBD	_	12	aux	_	_
12	fathered	father	VBN	VBN	_	8	acl:relcl	_	_
13	three	three	CD	CD	_	15	nummod	_	_
14	healthy	healthy	JJ	JJ	_	15	amod	_	_
15	children	child	NNS	NNS	_	12	dobj	_	_
16	,	,	,	,	_	8	punct	_	_
17	showed	show	VBD	VBD	_	0	root	_	_
18	an	a	DT	DT	_	20	det	_	_
19	identical	identical	JJ	JJ	_	20	amod	_	_
20	karyotype	karyotype	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	17	punct	_	_

1	Mosaicism	mosaicism	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	46,X,-Y,t(Y;15)(q12;p13)/45,X	46,x,-y,t(y;15)(q12;p13)/45,x	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	skin	skin	NN	NN	_	10	compound	_	_
10	samples	sample	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	patient	patient	NN	NN	_	18	nmod:poss	_	_
14	's	's	POS	POS	_	13	case	_	_
15	elbow	elbow	NN	NN	_	18	compound	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	genital	genital	JJ	JJ	_	15	conj	_	_
18	regions	region	NNS	NNS	_	10	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	although	although	IN	IN	_	22	mark	_	_
21	there	there	EX	EX	_	22	expl	_	_
22	were	be	VBD	VBD	_	7	advcl	_	_
23	no	no	DT	DT	_	25	neg	_	_
24	clinical	clinical	JJ	JJ	_	25	amod	_	_
25	stigmata	stigmata	NN	NN	_	22	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	Turner	turner	NN	NN	_	28	compound	_	_
28	syndrome	syndrome	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	An	a	DT	DT	_	5	det	_	_
2	androgen	androgen	NN	NN	_	5	compound	_	_
3	receptor	receptor	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	cultured	culture	VBN	VBN	_	10	amod	_	_
8	genital	genital	JJ	JJ	_	10	amod	_	_
9	skin	skin	NN	NN	_	10	compound	_	_
10	fibroblasts	fibroblast	NNS	NNS	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	negative	negative	JJ	JJ	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	14	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	Southern	southern	NN	NN	_	6	compound	_	_
5	blot	blot	NN	NN	_	6	compound	_	_
6	hybridisation	hybridisation	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	PCR	pcr	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	direct	direct	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	sequencing	sequencing	NN	NN	_	6	conj	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	22	mark	_	_
16	neither	neither	CC	CC	_	18	cc:preconj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	patient	patient	NN	NN	_	22	nsubj	_	_
19	nor	nor	CC	CC	_	18	cc	_	_
20	her	she	PRP$	PRP$	_	21	nmod:poss	_	_
21	brother	brother	NN	NN	_	18	conj	_	_
22	had	have	VBD	VBD	_	14	ccomp	_	_
23	a	a	DT	DT	_	25	det	_	_
24	detectable	detectable	JJ	JJ	_	25	amod	_	_
25	deletion	deletion	NN	NN	_	22	dobj	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	other	other	JJ	JJ	_	28	amod	_	_
28	abnormalities	abnormality	NNS	NNS	_	25	conj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	Y	y	NN	NN	_	32	compound	_	_
31	chromosome	chromosome	NN	NN	_	32	compound	_	_
32	sequences	sequence	NNS	NNS	_	25	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	including	include	VBG	VBG	_	47	case	_	_
35	the	the	DT	DT	_	47	det	_	_
36	SRY	sry	NN	NN	_	47	compound	_	_
37	(	(	-LRB-	-LRB-	_	47	punct	_	_
38	sex	sex	NN	NN	_	47	compound	_	_
39	determining	determining	NN	NN	_	47	compound	_	_
40	region	region	NN	NN	_	47	compound	_	_
41	of	of	IN	IN	_	47	amod	_	_
42	the	the	DT	DT	_	47	det	_	_
43	Y	y	NN	NN	_	47	compound	_	_
44	chromosome	chromosome	NN	NN	_	47	compound	_	_
45	)	)	-RRB-	-RRB-	_	47	punct	_	_
46	gene	gene	NN	NN	_	47	compound	_	_
47	sequence	sequence	NN	NN	_	32	nmod	_	_
48	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	Turner	turner	NN	NN	_	6	compound	_	_
6	mosaicism	mosaicism	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	45,X	45,x	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	6	nmod	_	_
12	may	may	MD	MD	_	14	aux	_	_
13	have	have	VB	VB	_	14	aux	_	_
14	contributed	contribute	VBN	VBN	_	3	ccomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	this	this	DT	DT	_	18	det	_	_
17	atypical	atypical	JJ	JJ	_	18	amod	_	_
18	presentation	presentation	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	XY	xy	NN	NN	_	22	compound	_	_
22	female	female	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	14	punct	_	_
24	although	although	IN	IN	_	28	mark	_	_
25	we	we	PRP	PRP	_	28	nsubj	_	_
26	can	can	MD	MD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	exclude	exclude	VB	VB	_	14	advcl	_	_
29	abnormalities	abnormality	NNS	NNS	_	28	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	other	other	JJ	JJ	_	32	amod	_	_
32	genes	gene	NNS	NNS	_	29	nmod	_	_
33	related	related	JJ	JJ	_	32	amod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	sex	sex	NN	NN	_	36	compound	_	_
36	differentiation	differentiation	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	3	amod	_	_
2	RNA	rna	NN	NN	_	3	compound	_	_
3	display	display	NN	NN	_	4	nsubj	_	_
4	identifies	identify	VBZ	VBZ	_	0	root	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	4	dobj	_	_
7	associated	associate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	13	case	_	_
9	decreased	decrease	VBN	VBN	_	13	amod	_	_
10	vitamin	vitamin	NN	NN	_	13	compound	_	_
11	D	d	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	18	advcl	_	_
3	further	further	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	function	function	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
9	vitamin	vitamin	NN	NN	_	11	compound	_	_
10	D	d	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	VDR	vdr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	developed	develop	VBN	VBN	_	0	root	_	_
19	stable	stable	JJ	JJ	_	21	amod	_	_
20	transfectant	transfectant	JJ	JJ	_	21	amod	_	_
21	variants	variant	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	vitamin	vitamin	NN	NN	_	27	compound	_	_
25	D-responsive	d-responsive	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	line	line	NN	NN	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	U937	u937	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	express	express	VBP	VBP	_	21	acl:relcl	_	_
33	either	either	CC	CC	_	34	cc:preconj	_	_
34	decreased	decrease	VBN	VBN	_	37	amod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	increased	increase	VBN	VBN	_	34	conj	_	_
37	numbers	number	NNS	NNS	_	32	dobj	_	_
38	of	of	IN	IN	_	39	case	_	_
39	VDR	vdr	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	analyzed	analyze	VBN	VBN	_	0	root	_	_
7	changes	change	NNS	NNS	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	associated	associate	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	16	case	_	_
13	this	this	DT	DT	_	16	det	_	_
14	variable	variable	JJ	JJ	_	16	amod	_	_
15	VDR	vdr	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Initial	initial	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	50	50	CD	CD	_	7	compound	_	_
7	%	%	NN	NN	_	8	amod	_	_
8	decrease	decrease	NN	NN	_	13	nsubjpass	_	_
9	in	in	IN	IN	_	11	case	_	_
10	VDR	vdr	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	3	ccomp	_	_
14	with	with	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	2-fold	2-fold	JJ	JJ	_	17	amod	_	_
17	increase	increase	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	proliferation	proliferation	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	a	a	DT	DT	_	24	det	_	_
23	similar	similar	JJ	JJ	_	24	amod	_	_
24	rise	rise	NN	NN	_	17	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	c-myc	c-myc	NN	NN	_	28	compound	_	_
27	mRNA	mrna	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	carried	carry	VBN	VBN	_	0	root	_	_
5	out	out	RP	RP	_	4	compound:prt	_	_
6	using	use	VBG	VBG	_	4	xcomp	_	_
7	differential	differential	JJ	JJ	_	9	amod	_	_
8	RNA	rna	NN	NN	_	9	compound	_	_
9	display	display	NN	NN	_	6	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	DD	dd	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	4	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DD	dd	NN	NN	_	5	compound	_	_
5	products	product	NNS	NNS	_	2	nmod	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	cDNAs	cdna	NNS	NNS	_	6	dobj	_	_
9	with	with	IN	IN	_	10	case	_	_
10	identity	identity	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	known	know	VBN	VBN	_	14	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	products	product	NNS	NNS	_	10	nmod	_	_
15	:	:	:	:	_	8	punct	_	_
16	the	the	DT	DT	_	21	det	_	_
17	catalytic	catalytic	JJ	JJ	_	21	amod	_	_
18	sub-unit	sub-unit	NN	NN	_	21	compound	_	_
19	of	of	IN	IN	_	21	amod	_	_
20	DNA-protein	dna-protein	JJ	JJ	_	21	amod	_	_
21	kinase	kinase	NN	NN	_	8	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	DNA-PK(CS)	dna-pk(cs)	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	the	the	DT	DT	_	32	det	_	_
28	peroxisomal	peroxisomal	JJ	JJ	_	32	amod	_	_
29	enzyme	enzyme	NN	NN	_	32	compound	_	_
30	17beta-hydroxysteroid	17beta-hydroxysteroid	NN	NN	_	32	compound	_	_
31	dehydrogenase	dehydrogenase	NN	NN	_	32	compound	_	_
32	type	type	NN	NN	_	21	conj	_	_
33	IV	iv	CD	CD	_	32	nummod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	17beta-HSD	17beta-hsd	NN	NN	_	32	appos	_	_
36	IV	iv	CD	CD	_	35	nummod	_	_
37	)	)	-RRB-	-RRB-	_	35	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	confirmed	confirm	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	expression	expression	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	both	both	DT	DT	_	8	det	_	_
8	mRNAs	mrna	NNS	NNS	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	reduced	reduce	VBN	VBN	_	3	ccomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	decreased	decrease	VBN	VBN	_	15	amod	_	_
15	numbers	number	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	VDR	vdr	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Down-regulation	down-regulation	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	17beta-HSD	17beta-hsd	NN	NN	_	6	compound	_	_
4	IV	iv	CD	CD	_	6	nummod	_	_
5	mRNA	mrna	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	enhanced	enhance	VBN	VBN	_	12	amod	_	_
11	estradiol	estradiol	NN	NN	_	12	compound	_	_
12	inactivation	inactivation	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
18	a	a	DT	DT	_	19	det	_	_
19	link	link	NN	NN	_	17	dobj	_	_
20	between	between	IN	IN	_	22	case	_	_
21	estrogenic	estrogenic	JJ	JJ	_	22	amod	_	_
22	pathways	pathway	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	proliferation	proliferation	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Further	further	JJ	JJ	_	3	amod	_	_
2	Northern	northern	NN	NN	_	3	compound	_	_
3	analyses	analysis	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	there	there	EX	EX	_	7	expl	_	_
7	was	be	VBD	VBD	_	4	ccomp	_	_
8	no	no	DT	DT	_	10	neg	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	change	change	NN	NN	_	7	nsubj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	17beta-HSD	17beta-hsd	NN	NN	_	10	nmod	_	_
13	IV	iv	CD	CD	_	12	nummod	_	_
14	or	or	CC	CC	_	12	cc	_	_
15	DNA-PK(CS)	dna-pk(cs)	NN	NN	_	17	compound	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	12	conj	_	_
18	following	follow	VBG	VBG	_	19	case	_	_
19	treatment	treatment	NN	NN	_	7	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	7	punct	_	_
23	although	although	IN	IN	_	28	mark	_	_
24	expression	expression	NN	NN	_	28	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	both	both	DT	DT	_	27	det	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	varied	vary	VBD	VBD	_	7	advcl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	changes	change	NNS	NNS	_	28	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	proliferation	proliferation	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	,	,	,	,	_	19	punct	_	_
6	in	in	IN	IN	_	11	case	_	_
7	addition	addition	NN	NN	_	11	dep	_	_
8	to	to	TO	TO	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	established	established	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	19	nmod	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	hormone-dependent	hormone-dependent	JJ	JJ	_	15	amod	_	_
15	trans-activator	trans-activator	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	VDR	vdr	NN	NN	_	19	nsubj	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	influence	influence	VB	VB	_	3	ccomp	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	ligand-independent	ligand-independent	JJ	JJ	_	24	amod	_	_
24	mechanisms	mechanism	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	c-fos	c-fos	NN	NN	_	5	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	c-jun	c-jun	NN	NN	_	1	conj	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	activated	activate	VBN	VBN	_	11	amod	_	_
8	cord	cord	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	adult	adult	JJ	JJ	_	8	conj	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
12	:	:	:	:	_	5	punct	_	_
13	an	a	DT	DT	_	14	det	_	_
14	analysis	analysis	NN	NN	_	5	dep	_	_
15	by	by	IN	IN	_	17	case	_	_
16	Northern	northern	NN	NN	_	17	compound	_	_
17	hybridization	hybridization	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	OBJECTIVES	objective	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	To	to	TO	TO	_	7	mark	_	_
6	further	further	RB	RB	_	7	advmod	_	_
7	analyze	analyze	VB	VB	_	27	advcl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	neonatal	neonatal	JJ	JJ	_	11	amod	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	7	dobj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	antigenic	antigenic	JJ	JJ	_	15	amod	_	_
15	challenge	challenge	NN	NN	_	11	nmod	_	_
16	such	such	JJ	JJ	_	19	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	blood	blood	NN	NN	_	19	compound	_	_
19	transfusion	transfusion	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	27	punct	_	_
21	c-fos	c-fos	NN	NN	_	25	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	c-jun	c-jun	NN	NN	_	21	conj	_	_
24	mRNA	mrna	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	27	nsubjpass	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	analyzed	analyze	VBN	VBN	_	1	dep	_	_
28	in	in	IN	IN	_	33	case	_	_
29	twelve	twelve	CD	CD	_	33	nummod	_	_
30	in-vitro-stimulated	in-vitro-stimulated	JJ	JJ	_	33	amod	_	_
31	normal	normal	JJ	JJ	_	33	amod	_	_
32	cord	cord	NN	NN	_	33	compound	_	_
33	blood	blood	NN	NN	_	27	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	ten	ten	CD	CD	_	40	nummod	_	_
36	in-vitro-stimulated	in-vitro-stimulated	JJ	JJ	_	40	amod	_	_
37	normal	normal	JJ	JJ	_	40	amod	_	_
38	adult	adult	JJ	JJ	_	40	amod	_	_
39	peripheral	peripheral	JJ	JJ	_	40	amod	_	_
40	blood	blood	NN	NN	_	33	conj	_	_
41	lymphocyte	lymphocyte	NN	NN	_	42	compound	_	_
42	samples	sample	NNS	NNS	_	33	dep	_	_
43	.	.	.	.	_	1	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	samples	sample	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	stimulated	stimulate	VBN	VBN	_	1	dep	_	_
9	by	by	IN	IN	_	13	case	_	_
10	either	either	CC	CC	_	13	cc:preconj	_	_
11	the	the	DT	DT	_	13	det	_	_
12	mitogen	mitogen	NN	NN	_	13	compound	_	_
13	phytohemagglutinin	phytohemagglutinin	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PHA	pha	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	or	or	CC	CC	_	13	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	monoclonal	monoclonal	JJ	JJ	_	21	amod	_	_
20	antibody	antibody	NN	NN	_	21	compound	_	_
21	alphaCD3	alphacd3	NN	NN	_	13	conj	_	_
22	.	.	.	.	_	1	punct	_	_

1	Proliferation	proliferation	NN	NN	_	2	compound	_	_
2	rate	rate	NN	NN	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Northern	northern	NN	NN	_	6	compound	_	_
5	blot	blot	NN	NN	_	6	compound	_	_
6	hybridization	hybridization	NN	NN	_	2	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	employed	employ	VBN	VBN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Cord	cord	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	1	appos	_	_
6	a	a	DT	DT	_	9	det	_	_
7	greater	greater	JJR	JJR	_	9	amod	_	_
8	proliferation	proliferation	NN	NN	_	9	compound	_	_
9	rate	rate	NN	NN	_	5	dobj	_	_
10	with	with	IN	IN	_	11	case	_	_
11	PHA	pha	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	alphaCD3	alphacd3	NN	NN	_	11	conj	_	_
14	than	than	IN	IN	_	16	case	_	_
15	adult	adult	JJ	JJ	_	16	amod	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	p	p	NN	NN	_	19	nsubj	_	_
19	=	=	JJ	JJ	_	9	dep	_	_
20	0.0081	0.0081	CD	CD	_	19	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	0.0023	0.0023	CD	CD	_	20	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	respectively	respectively	RB	RB	_	19	advmod	_	_
25	)	)	-RRB-	-RRB-	_	19	punct	_	_
26	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	Northern	northern	NN	NN	_	6	compound	_	_
5	blot	blot	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	cord	cord	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	adult	adult	JJ	JJ	_	8	conj	_	_
11	samples	sample	NNS	NNS	_	8	dep	_	_
12	revealed	reveal	VBD	VBD	_	0	root	_	_
13	similar	similar	JJ	JJ	_	15	amod	_	_
14	maximal	maximal	JJ	JJ	_	15	amod	_	_
15	increases	increase	NNS	NNS	_	12	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	c-fos	c-fos	NN	NN	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	25	punct	_	_
19	99+/-15	99+/-15	CD	CD	_	22	nummod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	126+/-11	126+/-11	CD	CD	_	19	conj	_	_
22	%	%	NN	NN	_	25	dep	_	_
23	,	,	,	,	_	25	punct	_	_
24	p	p	NN	NN	_	25	nsubj	_	_
25	=	=	JJ	JJ	_	17	dep	_	_
26	0.0126	0.0126	CD	CD	_	25	dobj	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	c-jun	c-jun	NN	NN	_	41	compound	_	_
30	(	(	-LRB-	-LRB-	_	37	punct	_	_
31	123+/-9	123+/-9	CD	CD	_	34	nummod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	185+/-38	185+/-38	CD	CD	_	31	conj	_	_
34	%	%	NN	NN	_	37	dep	_	_
35	,	,	,	,	_	37	punct	_	_
36	p	p	NN	NN	_	37	nsubj	_	_
37	=	=	JJ	JJ	_	41	dep	_	_
38	0.0291	0.0291	CD	CD	_	37	dobj	_	_
39	)	)	-RRB-	-RRB-	_	37	punct	_	_
40	mRNA	mrna	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	17	conj	_	_
42	,	,	,	,	_	12	punct	_	_
43	respectively	respectively	RB	RB	_	12	advmod	_	_
44	,	,	,	,	_	12	punct	_	_
45	as	as	RB	RB	_	46	advmod	_	_
46	early	early	RB	RB	_	12	advmod	_	_
47	as	as	IN	IN	_	51	case	_	_
48	15	15	CD	CD	_	49	compound	_	_
49	min	min	NN	NN	_	51	amod	_	_
50	post-alphaCD3	post-alphacd3	JJ	JJ	_	51	amod	_	_
51	stimulation	stimulation	NN	NN	_	46	nmod	_	_
52	.	.	.	.	_	12	punct	_	_

1	Adult	adult	JJ	JJ	_	2	amod	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	equivalent	equivalent	JJ	JJ	_	6	amod	_	_
6	increase	increase	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	mRNA	mrna	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	c-fos	c-fos	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	c-jun	c-jun	NN	NN	_	11	conj	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	140+/-25	140+/-25	CD	CD	_	18	nummod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	155+/-31	155+/-31	CD	CD	_	15	conj	_	_
18	%	%	NN	NN	_	9	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	at	at	IN	IN	_	24	case	_	_
21	30	30	CD	CD	_	22	compound	_	_
22	min	min	NN	NN	_	24	amod	_	_
23	post-PHA	post-pha	JJ	JJ	_	24	amod	_	_
24	stimulation	stimulation	NN	NN	_	3	nmod	_	_
25	,	,	,	,	_	3	punct	_	_
26	while	while	IN	IN	_	40	mark	_	_
27	cord	cord	NN	NN	_	30	compound	_	_
28	lymphocyte	lymphocyte	NN	NN	_	30	compound	_	_
29	maximum	maximum	NN	NN	_	30	compound	_	_
30	c-fos	c-fos	NN	NN	_	40	nsubj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	c-jun	c-jun	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	30	conj	_	_
34	(	(	-LRB-	-LRB-	_	38	punct	_	_
35	82+/-6	82+/-6	CD	CD	_	38	nummod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	142+/-12	142+/-12	CD	CD	_	35	conj	_	_
38	%	%	NN	NN	_	30	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	occurred	occur	VBD	VBD	_	3	advcl	_	_
41	at	at	IN	IN	_	45	case	_	_
42	15	15	CD	CD	_	43	compound	_	_
43	min	min	NN	NN	_	45	amod	_	_
44	post-PHA	post-pha	JJ	JJ	_	45	amod	_	_
45	stimulation	stimulation	NN	NN	_	40	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	c-fos	c-fos	NN	NN	_	40	dep	_	_
48	,	,	,	,	_	47	punct	_	_
49	p	p	NN	NN	_	50	nsubj	_	_
50	=	=	JJ	JJ	_	47	dep	_	_
51	0.0354	0.0354	CD	CD	_	50	dobj	_	_
52	;	;	:	:	_	47	punct	_	_
53	c-jun	c-jun	NN	NN	_	47	dep	_	_
54	,	,	,	,	_	53	punct	_	_
55	p	p	NN	NN	_	56	nsubj	_	_
56	=	=	JJ	JJ	_	53	dep	_	_
57	0.0112	0.0112	CD	CD	_	56	dobj	_	_
58	)	)	-RRB-	-RRB-	_	47	punct	_	_
59	.	.	.	.	_	3	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Although	although	IN	IN	_	10	mark	_	_
4	cord	cord	JJ	JJ	_	7	amod	_	_
5	lymphocyte	lymphocyte	NN	NN	_	7	compound	_	_
6	proliferation	proliferation	NN	NN	_	7	compound	_	_
7	rates	rate	NNS	NNS	_	10	nsubj	_	_
8	were	be	VBD	VBD	_	10	cop	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	greater	greater	JJR	JJR	_	31	advcl	_	_
11	than	than	IN	IN	_	12	case	_	_
12	those	those	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	adult	adult	JJ	JJ	_	15	amod	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
16	following	follow	VBG	VBG	_	17	case	_	_
17	stimulation	stimulation	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	31	punct	_	_
19	lymphocyte	lymphocyte	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	31	nsubj	_	_
21	,	,	,	,	_	31	punct	_	_
22	as	as	IN	IN	_	23	mark	_	_
23	analyzed	analyze	VBN	VBN	_	31	dep	_	_
24	by	by	IN	IN	_	29	case	_	_
25	c-fos	c-fos	NN	NN	_	29	compound	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	c-jun	c-jun	NN	NN	_	25	conj	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	23	nmod	_	_
30	,	,	,	,	_	31	punct	_	_
31	appears	appear	VBZ	VBZ	_	1	appos	_	_
32	similar	similar	JJ	JJ	_	31	xcomp	_	_
33	in	in	IN	IN	_	38	case	_	_
34	both	both	CC	CC	_	38	cc:preconj	_	_
35	cord	cord	NN	NN	_	38	compound	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	adult	adult	JJ	JJ	_	35	conj	_	_
38	samples	sample	NNS	NNS	_	31	nmod	_	_
39	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	cord	cord	NN	NN	_	6	compound	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	7	nsubj	_	_
7	exhibits	exhibit	VBZ	VBZ	_	2	ccomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	adult-type	adult-type	JJ	JJ	_	10	amod	_	_
10	profile	profile	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	2	punct	_	_

1	Downstream	downstream	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	TATA-less	tata-less	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	Oct-2	oct-2	NN	NN	_	2	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	Bob1	bob1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	8	conj	_	_
14	directs	direct	VBZ	VBZ	_	0	root	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	homing	homing	JJ	JJ	_	20	amod	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	BLR1	blr1	NN	NN	_	15	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	mature	mature	JJ	JJ	_	24	amod	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chemokine	chemokine	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	10	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	BLR1	blr1	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	major	major	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	microenvironmental	microenvironmental	JJ	JJ	_	14	amod	_	_
14	homing	homing	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	lymphoid	lymphoid	JJ	JJ	_	20	amod	_	_
20	organs	organ	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	identify	identify	VBP	VBP	_	0	root	_	_
5	three	three	CD	CD	_	7	nummod	_	_
6	essential	essential	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	TATA-less	tata-less	JJ	JJ	_	13	amod	_	_
11	blr1	blr1	NN	NN	_	13	compound	_	_
12	core	core	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	7	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	confer	confer	VBP	VBP	_	7	acl:relcl	_	_
16	cell	cell	NN	NN	_	17	dep	_	_
17	type-	type-	NN	NN	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	differentiation-specific	differentiation-specific	JJ	JJ	_	17	conj	_	_
20	expression	expression	NN	NN	_	15	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	humans	human	NNS	NNS	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	mice	mouse	NNS	NNS	_	27	conj	_	_
30	,	,	,	,	_	7	punct	_	_
31	a	a	DT	DT	_	34	det	_	_
32	functional	functional	JJ	JJ	_	34	amod	_	_
33	promoter	promoter	NN	NN	_	34	compound	_	_
34	region	region	NN	NN	_	7	appos	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	-36	-36	CD	CD	_	34	dep	_	_
37	with	with	IN	IN	_	43	case	_	_
38	respect	respect	NN	NN	_	43	dep	_	_
39	to	to	TO	TO	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	transcription	transcription	NN	NN	_	43	compound	_	_
42	start	start	NN	NN	_	43	compound	_	_
43	site	site	NN	NN	_	36	nmod	_	_
44	)	)	-RRB-	-RRB-	_	36	punct	_	_
45	,	,	,	,	_	34	punct	_	_
46	a	a	DT	DT	_	48	det	_	_
47	NF-kappaB	nf-kappab	NN	NN	_	48	compound	_	_
48	motif	motif	NN	NN	_	34	conj	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	+44	+44	CD	CD	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	,	,	,	,	_	34	punct	_	_
53	and	and	CC	CC	_	34	cc	_	_
54	a	a	DT	DT	_	57	det	_	_
55	noncanonical	noncanonical	JJ	JJ	_	57	amod	_	_
56	octamer	octamer	NN	NN	_	57	compound	_	_
57	motif	motif	NN	NN	_	34	conj	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	+157	+157	CD	CD	_	57	appos	_	_
60	)	)	-RRB-	-RRB-	_	59	punct	_	_
61	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	sites	site	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vivo	vivo	FW	FW	_	9	dep	_	_
11	studies	study	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	gene-targeted	gene-targeted	JJ	JJ	_	14	amod	_	_
14	mice	mouse	NNS	NNS	_	11	nmod	_	_
15	deficient	deficient	JJ	JJ	_	14	amod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	either	either	CC	CC	_	18	cc:preconj	_	_
18	Oct-2	oct-2	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	Bob1	bob1	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	or	or	CC	CC	_	18	cc	_	_
23	both	both	CC	CC	_	25	cc:preconj	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	25	compound	_	_
25	subunits	subunit	NNS	NNS	_	18	conj	_	_
26	p50	p50	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	p52	p52	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	all	all	DT	DT	_	12	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	animals	animal	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	BLR1	blr1	NN	NN	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	reduced	reduce	VBN	VBN	_	0	root	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	absent	absent	JJ	JJ	_	12	conj	_	_
15	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	mice	mouse	NNS	NNS	_	11	nmod	_	_
3	deficient	deficient	JJ	JJ	_	2	amod	_	_
4	only	only	RB	RB	_	6	advmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	p52/NF-kappaB	p52/nf-kappab	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	BLR1	blr1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	unaffected	unaffected	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	data	datum	NNS	NNS	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	BLR1	blr1	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	4	ccomp	_	_
11	for	for	IN	IN	_	12	case	_	_
12	Oct-2	oct-2	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	Bob1	bob1	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	members	member	NNS	NNS	_	12	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	21	compound	_	_
21	family	family	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	10	cc	_	_
23	provides	provide	VBZ	VBZ	_	10	conj	_	_
24	a	a	DT	DT	_	25	det	_	_
25	link	link	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	impaired	impaired	JJ	JJ	_	31	amod	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	functions	function	NNS	NNS	_	25	nmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	mice	mouse	NNS	NNS	_	31	nmod	_	_
34	deficient	deficient	JJ	JJ	_	33	amod	_	_
35	for	for	IN	IN	_	37	case	_	_
36	these	these	DT	DT	_	37	det	_	_
37	factors	factor	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	coproporphyrinogen	coproporphyrinogen	NN	NN	_	6	compound	_	_
5	oxidase	oxidase	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	between	between	IN	IN	_	11	case	_	_
8	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	nonerythroid	nonerythroid	JJ	JJ	_	8	conj	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Coproporphyrinogen	coproporphyrinogen	NN	NN	_	2	compound	_	_
2	oxidase	oxidase	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	CPO	cpo	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	catalyzes	catalyze	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	sixth	sixth	JJ	JJ	_	9	amod	_	_
9	step	step	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	heme	heme	NN	NN	_	14	compound	_	_
13	biosynthetic	biosynthetic	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	assess	assess	VB	VB	_	19	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	tissue-specific	tissue-specific	JJ	JJ	_	5	amod	_	_
5	regulation	regulation	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	CPO	cpo	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	19	punct	_	_
12	mouse	mouse	NN	NN	_	15	compound	_	_
13	genomic	genomic	JJ	JJ	_	15	amod	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	clones	clone	NNS	NNS	_	19	nsubjpass	_	_
16	for	for	IN	IN	_	17	case	_	_
17	CPO	cpo	NN	NN	_	15	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	isolated	isolate	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Structural	structural	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	mouse	mouse	NN	NN	_	8	compound	_	_
7	CPO	cpo	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	9	nsubj	_	_
9	spans	span	VBZ	VBZ	_	3	ccomp	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	11	11	CD	CD	_	12	nummod	_	_
12	kb	kb	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	consists	consist	VBZ	VBZ	_	9	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	seven	seven	CD	CD	_	17	nummod	_	_
17	exons	exon	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	just	just	RB	RB	_	23	advmod	_	_
20	like	like	IN	IN	_	23	case	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	counterpart	counterpart	NN	NN	_	9	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	promoter	promoter	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	transient	transient	JJ	JJ	_	9	amod	_	_
8	transfection	transfection	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	2	nmod	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	41	mark	_	_
12	synergistic	synergistic	JJ	JJ	_	13	amod	_	_
13	action	action	NN	NN	_	41	nsubj	_	_
14	between	between	IN	IN	_	17	case	_	_
15	an	a	DT	DT	_	17	det	_	_
16	SP-1-like	sp-1-like	JJ	JJ	_	17	amod	_	_
17	element	element	NN	NN	_	13	nmod	_	_
18	at	at	IN	IN	_	19	case	_	_
19	-21/-12	-21/-12	CD	CD	_	17	nmod	_	_
20	,	,	,	,	_	17	punct	_	_
21	a	a	DT	DT	_	23	det	_	_
22	GATA	gata	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	17	appos	_	_
24	at	at	IN	IN	_	25	case	_	_
25	-59/-54	-59/-54	CD	CD	_	23	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	and	and	CC	CC	_	17	cc	_	_
28	a	a	DT	DT	_	31	det	_	_
29	novel	novel	JJ	JJ	_	31	amod	_	_
30	regulatory	regulatory	JJ	JJ	_	31	amod	_	_
31	element	element	NN	NN	_	17	conj	_	_
32	,	,	,	,	_	31	punct	_	_
33	CPRE	cpre	NN	NN	_	31	appos	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	-GGACTACAG-	-ggactacag-	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	at	at	IN	IN	_	38	case	_	_
38	-49/-41	-49/-41	CD	CD	_	33	nmod	_	_
39	,	,	,	,	_	31	punct	_	_
40	is	be	VBZ	VBZ	_	41	cop	_	_
41	essential	essential	JJ	JJ	_	10	ccomp	_	_
42	for	for	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	promoter	promoter	NN	NN	_	45	compound	_	_
45	activity	activity	NN	NN	_	41	nmod	_	_
46	in	in	IN	IN	_	52	case	_	_
47	murine	murine	JJ	JJ	_	52	amod	_	_
48	erythroleukemia	erythroleukemia	NN	NN	_	52	compound	_	_
49	(	(	-LRB-	-LRB-	_	52	punct	_	_
50	MEL	mel	NN	NN	_	52	compound	_	_
51	)	)	-RRB-	-RRB-	_	52	punct	_	_
52	cells	cell	NNS	NNS	_	45	nmod	_	_
53	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	nonerythroid	nonerythroid	JJ	JJ	_	4	amod	_	_
3	NIH3T3	nih3t3	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	however	however	RB	RB	_	13	advmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	required	require	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	specific	specific	JJ	JJ	_	9	amod	_	_
8	DNA-protein	dna-protein	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	12	nsubjpass	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	formed	form	VBN	VBN	_	5	ccomp	_	_
13	with	with	IN	IN	_	15	case	_	_
14	each	each	DT	DT	_	15	det	_	_
15	element	element	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	there	there	EX	EX	_	20	expl	_	_
20	are	be	VBP	VBP	_	12	conj	_	_
21	cell-specific	cell-specific	JJ	JJ	_	22	amod	_	_
22	differences	difference	NNS	NNS	_	20	nsubj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	factors	factor	NNS	NNS	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	bind	bind	VBP	VBP	_	24	acl:relcl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	SP-1-like	sp-1-like	JJ	JJ	_	31	amod	_	_
31	element	element	NN	NN	_	27	nmod	_	_
32	between	between	IN	IN	_	36	case	_	_
33	MEL	mel	NN	NN	_	36	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	NIH3T3	nih3t3	NN	NN	_	33	conj	_	_
36	cells	cell	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	CPO	cpo	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	11	nmod	_	_
15	between	between	IN	IN	_	19	case	_	_
16	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	nonerythroid	nonerythroid	JJ	JJ	_	16	conj	_	_
19	cells	cell	NNS	NNS	_	7	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	by	by	IN	IN	_	6	case	_	_
4	The	The	NNP	NNP	_	6	compound	_	_
5	American	American	NNP	NNP	_	6	compound	_	_
6	Society	Society	NNP	NNP	_	2	dep	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Hematology	Hematology	NNP	NNP	_	6	nmod	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	RNA	rna	NN	NN	_	6	compound	_	_
4	polymerase	polymerase	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	transcription	transcription	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	synthetic	synthetic	JJ	JJ	_	13	amod	_	_
12	DNA-binding	dna-binding	JJ	JJ	_	13	amod	_	_
13	ligands	ligand	NNS	NNS	_	1	nmod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	see	see	VB	VB	_	1	dep	_	_
16	comments	comment	NNS	NNS	_	15	dobj	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_

1	Sequence-specific	sequence-specific	JJ	JJ	_	4	amod	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	4	amod	_	_
3	small	small	JJ	JJ	_	4	amod	_	_
4	molecules	molecule	NNS	NNS	_	12	nsubj	_	_
5	that	that	WDT	WDT	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	permeate	permeate	VB	VB	_	4	acl:relcl	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	7	dobj	_	_
10	potentially	potentially	RB	RB	_	12	advmod	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	regulate	regulate	VB	VB	_	0	root	_	_
13	transcription	transcription	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Multiple	multiple	JJ	JJ	_	5	amod	_	_
2	cellular	cellular	JJ	JJ	_	5	amod	_	_
3	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factors	factor	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	type	type	NN	NN	_	7	nmod	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	RNA	rna	NN	NN	_	14	compound	_	_
14	synthesis	synthesis	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	pyrrole-imidazole	pyrrole-imidazole	JJ	JJ	_	3	amod	_	_
3	polyamides	polyamide	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	designed	design	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	bind	bind	VB	VB	_	5	xcomp	_	_
8	DNA	dna	NN	NN	_	9	compound	_	_
9	sequences	sequence	NNS	NNS	_	7	dobj	_	_
10	immediately	immediately	RB	RB	_	11	advmod	_	_
11	adjacent	adjacent	JJ	JJ	_	9	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	sites	site	NNS	NNS	_	11	nmod	_	_
15	for	for	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	transcription	transcription	NN	NN	_	19	compound	_	_
18	factors	factor	NNS	NNS	_	19	compound	_	_
19	Ets-1	ets-1	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	lymphoid-enhancer	lymphoid-enhancer	JJ	JJ	_	23	amod	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	19	conj	_	_
24	1	1	CD	CD	_	23	nummod	_	_
25	,	,	,	,	_	19	punct	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	TATA-box	tata-box	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	19	conj	_	_
30	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	synthetic	synthetic	JJ	JJ	_	3	amod	_	_
3	ligands	ligand	NNS	NNS	_	5	nsubj	_	_
4	specifically	specifically	RB	RB	_	5	advmod	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	DNA-binding	dna-binding	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	each	each	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	HIV	hiv	NN	NN	_	15	compound	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	transcription	transcription	NN	NN	_	6	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	cell-free	cell-free	JJ	JJ	_	18	amod	_	_
18	assays	assay	NNS	NNS	_	5	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	used	use	VBN	VBN	_	8	advcl	_	_
3	in	in	IN	IN	_	4	case	_	_
4	combination	combination	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	polyamides	polyamide	NNS	NNS	_	8	nsubj	_	_
8	inhibit	inhibit	VBP	VBP	_	0	root	_	_
9	virus	virus	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	&gt;	&gt;	JJR	JJR	_	13	advmod	_	_
13	99	99	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	8	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	isolated	isolate	VBN	VBN	_	20	amod	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	with	with	IN	IN	_	26	case	_	_
23	no	no	DT	DT	_	26	neg	_	_
24	detectable	detectable	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	toxicity	toxicity	NN	NN	_	8	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	small	small	JJ	JJ	_	5	amod	_	_
5	molecules	molecule	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	target	target	VB	VB	_	2	acl	_	_
8	predetermined	predetermined	JJ	JJ	_	10	amod	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	sequences	sequence	NNS	NNS	_	7	dobj	_	_
11	located	located	JJ	JJ	_	10	amod	_	_
12	within	within	IN	IN	_	16	case	_	_
13	RNA	rna	NN	NN	_	16	compound	_	_
14	polymerase	polymerase	NN	NN	_	16	compound	_	_
15	II	ii	CD	CD	_	16	nummod	_	_
16	promoters	promoter	NNS	NNS	_	11	nmod	_	_
17	suggests	suggest	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	general	general	JJ	JJ	_	20	amod	_	_
20	approach	approach	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	regulation	regulation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	as	as	RB	RB	_	20	cc	_	_
28	well	well	RB	RB	_	27	mwe	_	_
29	as	as	IN	IN	_	27	mwe	_	_
30	a	a	DT	DT	_	31	det	_	_
31	mechanism	mechanism	NN	NN	_	20	conj	_	_
32	for	for	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	inhibition	inhibition	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	viral	viral	JJ	JJ	_	37	amod	_	_
37	replication	replication	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	caspases	caspase	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	control	control	NN	NN	_	2	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	responsible	responsible	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	removal	removal	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	potentially	potentially	RB	RB	_	9	advmod	_	_
9	autoreactive	autoreactive	JJ	JJ	_	13	amod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	useless	useless	JJ	JJ	_	9	conj	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	during	during	IN	IN	_	16	case	_	_
15	thymic	thymic	JJ	JJ	_	16	amod	_	_
16	selection	selection	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	13	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	periphery	periphery	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	families	family	NNS	NNS	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	receptors	receptor	NNS	NNS	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	kinases	kinase	NNS	NNS	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	4	conj	_	_
10	,	,	,	,	_	4	punct	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	cysteine	cysteine	NN	NN	_	13	compound	_	_
13	proteases	protease	NNS	NNS	_	4	conj	_	_
14	,	,	,	,	_	13	punct	_	_
15	termed	term	VBN	VBN	_	13	acl	_	_
16	caspases	caspase	NNS	NNS	_	15	xcomp	_	_
17	,	,	,	,	_	13	punct	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	involved	involve	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	apoptotic	apoptotic	JJ	JJ	_	23	amod	_	_
23	cascade	cascade	NN	NN	_	19	nmod	_	_
24	leading	lead	VBG	VBG	_	23	acl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	proteolysis	proteolysis	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	specific	specific	JJ	JJ	_	29	amod	_	_
29	substrates	substrate	NNS	NNS	_	26	nmod	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	to	to	TO	TO	_	33	case	_	_
32	morphological	morphological	JJ	JJ	_	33	amod	_	_
33	changes	change	NNS	NNS	_	26	conj	_	_
34	associated	associate	VBN	VBN	_	33	acl	_	_
35	with	with	IN	IN	_	38	case	_	_
36	programmed	program	VBN	VBN	_	38	amod	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	death	death	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	19	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	common	common	JJ	JJ	_	3	amod	_	_
3	members	member	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	apoptotic	apoptotic	JJ	JJ	_	7	amod	_	_
7	cascade	cascade	NN	NN	_	3	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	shared	share	VBN	VBN	_	16	advcl	_	_
10	between	between	IN	IN	_	13	case	_	_
11	different	different	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	types	type	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	appears	appear	VBZ	VBZ	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
19	factors	factor	NNS	NNS	_	21	nsubj	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	influence	influence	VB	VB	_	16	ccomp	_	_
22	the	the	DT	DT	_	23	det	_	_
23	response	response	NN	NN	_	21	dobj	_	_
24	to	to	TO	TO	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	given	given	JJ	JJ	_	28	amod	_	_
27	apoptotic	apoptotic	JJ	JJ	_	28	amod	_	_
28	stimuli	stimulus	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	16	punct	_	_

1	Characterization	characterization	NN	NN	_	20	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	understanding	understanding	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	basic	basic	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	1	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	pathways	pathway	NNS	NNS	_	8	nmod	_	_
13	protecting	protect	VBG	VBG	_	12	dep	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	leading	lead	VBG	VBG	_	13	conj	_	_
16	to	to	TO	TO	_	15	nmod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	death	death	NN	NN	_	13	dobj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	provide	provide	VB	VB	_	0	root	_	_
21	novel	novel	JJ	JJ	_	22	amod	_	_
22	ways	way	NNS	NNS	_	20	dobj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	control	control	VB	VB	_	22	acl	_	_
25	inappropriate	inappropriate	JJ	JJ	_	26	amod	_	_
26	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
27	involved	involve	VBN	VBN	_	26	acl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	several	several	JJ	JJ	_	30	amod	_	_
30	diseases	disease	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	20	punct	_	_

1	Interleukin	interleukin	NN	NN	_	2	compound	_	_
2	1beta	1beta	NN	NN	_	3	nsubj	_	_
3	mediates	mediate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	modulatory	modulatory	JJ	JJ	_	6	amod	_	_
6	effects	effect	NNS	NNS	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	on	on	IN	IN	_	14	case	_	_
10	LNCaP	lncap	NN	NN	_	14	compound	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	prostate	prostate	NN	NN	_	14	compound	_	_
13	cancer	cancer	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Proliferative	proliferative	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	secretory	secretory	JJ	JJ	_	1	conj	_	_
4	responses	response	NNS	NNS	_	12	nsubjpass	_	_
5	in	in	IN	IN	_	10	case	_	_
6	androgen-sensitive	androgen-sensitive	JJ	JJ	_	10	amod	_	_
7	prostate	prostate	NN	NN	_	10	compound	_	_
8	cancer	cancer	NN	NN	_	10	compound	_	_
9	LNCaP	lncap	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	steroid	steroid	NN	NN	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	peptide	peptide	NN	NN	_	14	conj	_	_
17	hormones	hormone	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	by	by	IN	IN	_	21	case	_	_
20	differentiation-promoting	differentiation-promoting	JJ	JJ	_	21	amod	_	_
21	substances	substance	NNS	NNS	_	17	conj	_	_
22	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	evaluated	evaluate	VBD	VBD	_	0	root	_	_
8	whether	whether	IN	IN	_	21	mark	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	monocytes	monocyte	NNS	NNS	_	21	nsubj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	exhibit	exhibit	VBP	VBP	_	11	acl:relcl	_	_
14	anti-tumour	anti-tumour	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	haematopoietic	haematopoietic	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	solid	solid	JJ	JJ	_	17	conj	_	_
20	tumours	tumour	NNS	NNS	_	15	nmod	_	_
21	influence	influence	VBP	VBP	_	7	ccomp	_	_
22	growth	growth	NN	NN	_	21	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	secretion	secretion	NN	NN	_	22	conj	_	_
25	in	in	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	LNCaP	lncap	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	LNCaP	lncap	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	incubated	incubate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	monocyte-conditioned	monocyte-conditioned	JJ	JJ	_	11	amod	_	_
11	medium	medium	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	MCM	mcm	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	proliferation	proliferation	NN	NN	_	37	nsubjpass	_	_
18	as	as	RB	RB	_	17	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	expression	expression	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	androgen	androgen	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	17	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	AR	ar	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	17	cc	_	_
29	secretion	secretion	NN	NN	_	17	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	prostate-specific	prostate-specific	JJ	JJ	_	32	amod	_	_
32	antigen	antigen	NN	NN	_	29	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PSA	psa	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	were	be	VBD	VBD	_	37	auxpass	_	_
37	assessed	assess	VBN	VBN	_	8	conj	_	_
38	.	.	.	.	_	8	punct	_	_

1	Conditioned	conditioned	JJ	JJ	_	2	amod	_	_
2	medium	medium	NN	NN	_	5	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
5	reduced	reduce	VBD	VBD	_	0	root	_	_
6	proliferation	proliferation	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dose-dependent	dose-dependent	JJ	JJ	_	10	amod	_	_
10	manner	manner	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Incubation	incubation	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	40	40	CD	CD	_	4	compound	_	_
4	%	%	NN	NN	_	5	amod	_	_
5	MCM	mcm	NN	NN	_	1	nmod	_	_
6	caused	cause	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	50	50	CD	CD	_	9	compound	_	_
9	%	%	NN	NN	_	10	amod	_	_
10	reduction	reduction	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	AR	ar	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	decreased	decrease	VBD	VBD	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	70	70	CD	CD	_	6	nummod	_	_
6	%	%	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	PSA	psa	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	16	nsubjpass	_	_
10	in	in	IN	IN	_	11	case	_	_
11	supernatants	supernatant	NNS	NNS	_	9	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	LNCaP	lncap	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	reduced	reduce	VBN	VBN	_	3	conj	_	_
17	by	by	IN	IN	_	20	case	_	_
18	approximately	approximately	RB	RB	_	19	advmod	_	_
19	80	80	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	16	nmod	_	_
21	following	follow	VBG	VBG	_	22	case	_	_
22	treatment	treatment	NN	NN	_	16	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	MCM	mcm	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	focused	focus	VBD	VBD	_	0	root	_	_
3	on	on	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	contribution	contribution	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	major	major	JJ	JJ	_	9	amod	_	_
9	products	product	NNS	NNS	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	prostaglandin	prostaglandin	NN	NN	_	15	compound	_	_
15	E2	e2	NN	NN	_	9	appos	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	interleukin	interleukin	NN	NN	_	18	compound	_	_
18	1beta	1beta	NN	NN	_	15	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IL-1beta	il-1beta	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	9	punct	_	_
23	to	to	TO	TO	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	MCM	mcm	NN	NN	_	27	compound	_	_
26	modulatory	modulatory	JJ	JJ	_	27	amod	_	_
27	action	action	NN	NN	_	5	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	LNCaP	lncap	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	7	nsubj	_	_
3	treated	treat	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	6	case	_	_
5	prostaglandin	prostaglandin	NN	NN	_	6	compound	_	_
6	E2	e2	NN	NN	_	3	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	neither	neither	CC	CC	_	10	cc:preconj	_	_
9	a	a	DT	DT	_	10	det	_	_
10	reduction	reduction	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	proliferation	proliferation	NN	NN	_	10	nmod	_	_
13	nor	nor	CC	CC	_	10	cc	_	_
14	a	a	DT	DT	_	15	det	_	_
15	down-regulation	down-regulation	NN	NN	_	10	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	AR	ar	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	PSA	psa	NN	NN	_	17	conj	_	_
20	levels	level	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	MCM	mcm	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	proliferation	proliferation	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	AR	ar	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	PSA	psa	NN	NN	_	13	compound	_	_
13	secretion	secretion	NN	NN	_	7	conj	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	abolished	abolish	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	pretreatment	pretreatment	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	MCM	mcm	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	neutralizing	neutralize	VBG	VBG	_	24	amod	_	_
23	anti-IL-1beta	anti-il-1beta	NN	NN	_	24	compound	_	_
24	antibody	antibody	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	recombinant	recombinant	JJ	JJ	_	5	amod	_	_
5	IL-1beta	il-1beta	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	replace	replace	VB	VB	_	7	xcomp	_	_
10	MCM	mcm	NN	NN	_	9	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	inhibition	inhibition	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	proliferation	proliferation	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	down-regulation	down-regulation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	AR	ar	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	PSA	psa	NN	NN	_	19	conj	_	_
22	proteins	protein	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	LNCaP	lncap	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	express	express	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	10	det	_	_
8	IL-1beta	il-1beta	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	type	type	NN	NN	_	6	dobj	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	10	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	transduces	transduce	VBZ	VBZ	_	10	acl:relcl	_	_
15	IL-1beta	il-1beta	NN	NN	_	16	compound	_	_
16	signal	signal	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	monocyte-derived	monocyte-derived	JJ	JJ	_	6	amod	_	_
6	IL-1beta	il-1beta	NN	NN	_	7	nsubj	_	_
7	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	proliferation	proliferation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	androgen-responsive	androgen-responsive	JJ	JJ	_	14	amod	_	_
12	prostate	prostate	NN	NN	_	14	compound	_	_
13	tumour	tumour	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	reduces	reduce	VBZ	VBZ	_	7	conj	_	_
17	AR	ar	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	PSA	psa	NN	NN	_	17	conj	_	_
20	levels	level	NNS	NNS	_	16	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factors	factor	NNS	NNS	_	1	nmod	_	_
5	expressed	express	VBN	VBN	_	4	acl	_	_
6	during	during	IN	IN	_	9	case	_	_
7	ATRA-induced	atra-induced	JJ	JJ	_	9	amod	_	_
8	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HL60	hl60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	recent	recent	JJ	JJ	_	5	amod	_	_
3	clinical	clinical	JJ	JJ	_	5	amod	_	_
4	therapeutic	therapeutic	JJ	JJ	_	5	amod	_	_
5	initiative	initiative	NN	NN	_	9	nsubj	_	_
6	has	have	VBZ	VBZ	_	9	aux	_	_
7	been	be	VBN	VBN	_	9	cop	_	_
8	the	the	DT	DT	_	9	det	_	_
9	use	use	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	chemical	chemical	JJ	JJ	_	12	amod	_	_
12	agents	agent	NNS	NNS	_	9	nmod	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	induce	induce	VBP	VBP	_	12	acl:relcl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	leukaemic	leukaemic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	dobj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	overcome	overcome	VB	VB	_	14	xcomp	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	block	block	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	differentiation	differentiation	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	understand	understand	VB	VB	_	12	advcl	_	_
5	this	this	DT	DT	_	6	det	_	_
6	block	block	NN	NN	_	4	dobj	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cascade	cascade	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	events	event	NNS	NNS	_	8	nmod	_	_
12	needs	need	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	characterized	characterize	VBN	VBN	_	12	xcomp	_	_
16	.	.	.	.	_	12	punct	_	_

1	Haemopoietic	haemopoietic	JJ	JJ	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	ultimately	ultimately	RB	RB	_	5	advmod	_	_
5	controlled	control	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	level	level	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	8	nmod	_	_
12	which	which	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	11	acl:relcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	an	a	DT	DT	_	17	det	_	_
17	array	array	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Many	many	JJ	JJ	_	3	amod	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	contain	contain	VBP	VBP	_	0	root	_	_
5	similar	similar	JJ	JJ	_	8	amod	_	_
6	structural	structural	JJ	JJ	_	8	amod	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	sequences	sequence	NNS	NNS	_	4	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	used	use	VBN	VBN	_	4	conj	_	_
14	an	a	DT	DT	_	16	det	_	_
15	RT-PCR-based	rt-pcr-based	JJ	JJ	_	16	amod	_	_
16	approach	approach	NN	NN	_	13	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	isolate	isolate	VB	VB	_	13	advcl	_	_
19	sequences	sequence	NNS	NNS	_	18	dobj	_	_
20	,	,	,	,	_	18	punct	_	_
21	from	from	IN	IN	_	25	case	_	_
22	transcription	transcription	NN	NN	_	25	compound	_	_
23	factor	factor	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	families	family	NNS	NNS	_	18	nmod	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	share	share	VBP	VBP	_	25	acl:relcl	_	_
28	similar	similar	JJ	JJ	_	29	amod	_	_
29	domains	domain	NNS	NNS	_	27	dobj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Degenerate	degenerate	NN	NN	_	2	compound	_	_
2	primers	primer	NNS	NNS	_	20	nsubjpass	_	_
3	corresponding	correspond	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	TFIIIA	tfiiia	NN	NN	_	11	compound	_	_
7	zinc-finger	zinc-finger	JJ	JJ	_	11	amod	_	_
8	consensus	consensus	NN	NN	_	11	compound	_	_
9	amino	amino	NN	NN	_	11	compound	_	_
10	acid	acid	NN	NN	_	11	compound	_	_
11	sequences	sequence	NNS	NNS	_	3	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	POU-homeodomain	pou-homeodomain	NN	NN	_	11	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	POU-specific	pou-specific	JJ	JJ	_	18	amod	_	_
18	domain	domain	NN	NN	_	15	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	used	use	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	amplify	amplify	VB	VB	_	20	xcomp	_	_
23	genes	gene	NNS	NNS	_	22	dobj	_	_
24	on	on	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	basis	basis	NN	NN	_	20	nmod	_	_
27	that	that	IN	IN	_	29	mark	_	_
28	they	they	PRP	PRP	_	29	nsubj	_	_
29	contained	contain	VBD	VBD	_	26	ccomp	_	_
30	similarities	similarity	NNS	NNS	_	29	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	structural	structural	JJ	JJ	_	33	amod	_	_
33	motifs	motif	NNS	NNS	_	30	nmod	_	_
34	shared	share	VBN	VBN	_	33	acl	_	_
35	within	within	IN	IN	_	37	case	_	_
36	these	these	DT	DT	_	37	det	_	_
37	families	family	NNS	NNS	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	transcription	transcription	NN	NN	_	40	compound	_	_
40	factors	factor	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	20	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	serum-independent	serum-independent	JJ	JJ	_	5	amod	_	_
3	HL60	hl60	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	induced	induce	VBN	VBN	_	0	root	_	_
8	towards	towards	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	neutrophil	neutrophil	NN	NN	_	11	compound	_	_
11	lineage	lineage	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	treatment	treatment	NN	NN	_	7	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	all-trans	all-trans	JJ	JJ	_	17	amod	_	_
16	retinoic	retinoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATRA	atra	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	for	for	IN	IN	_	23	case	_	_
22	24	24	CD	CD	_	23	nummod	_	_
23	h	h	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	CD38+	cd38+	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	8	nsubj	_	_
3	committed	commit	VBN	VBN	_	2	acl	_	_
4	towards	towards	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	lineage	lineage	NN	NN	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	aux	_	_
8	enriched	enriched	JJ	JJ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	11	det	_	_
11	population	population	NN	NN	_	15	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	these	these	DT	DT	_	14	det	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	treated	treat	VBN	VBN	_	8	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	18	compound	_	_
18	D3	d3	NN	NN	_	15	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	induce	induce	VB	VB	_	15	xcomp	_	_
21	neutrophil	neutrophil	NN	NN	_	22	compound	_	_
22	maturation	maturation	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	RNA	rna	NN	NN	_	18	nsubjpass	_	_
2	extracted	extract	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	8	case	_	_
4	uninduced	uninduced	JJ	JJ	_	8	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	ATRA-induced	atra-induced	JJ	JJ	_	4	dep	_	_
7	CD38+	cd38+	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	vitamin	vitamin	NN	NN	_	16	compound	_	_
12	D3	d3	NN	NN	_	16	compound	_	_
13	treated	treated	JJ	JJ	_	16	amod	_	_
14	maturing	maturing	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	cultures	culture	NNS	NNS	_	1	conj	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	amplified	amplify	VBN	VBN	_	0	root	_	_
19	using	use	VBG	VBG	_	18	xcomp	_	_
20	the	the	DT	DT	_	22	det	_	_
21	degenerate	degenerate	NN	NN	_	22	compound	_	_
22	primers	primer	NNS	NNS	_	19	dobj	_	_
23	.	.	.	.	_	18	punct	_	_

1	PCR	pcr	NN	NN	_	2	compound	_	_
2	fragments	fragment	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	aux	_	_
4	cloned	clone	VBN	VBN	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	sequenced	sequence	VBN	VBN	_	4	dep	_	_
7	,	,	,	,	_	4	punct	_	_
8	clustered	cluster	VBN	VBN	_	4	dep	_	_
9	into	into	IN	IN	_	11	case	_	_
10	homologous	homologous	JJ	JJ	_	11	amod	_	_
11	groups	group	NNS	NNS	_	4	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	group	group	NN	NN	_	16	compound	_	_
16	sequences	sequence	NNS	NNS	_	17	nsubj	_	_
17	searched	search	VBN	VBN	_	4	conj	_	_
18	on	on	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	GenBank	genbank	NN	NN	_	21	compound	_	_
21	database	database	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Oct	oct	NN	NN	_	5	compound	_	_
3	1	1	CD	CD	_	5	nummod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	16	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	a	a	DT	DT	_	11	det	_	_
9	very	very	RB	RB	_	10	advmod	_	_
10	close	close	JJ	JJ	_	11	amod	_	_
11	homologue	homologue	NN	NN	_	5	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	KIAA0144	kiaa0144	NN	NN	_	11	appos	_	_
14	,	,	,	,	_	11	punct	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	0	root	_	_
17	using	use	VBG	VBG	_	16	xcomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	POU	pou	NN	NN	_	21	compound	_	_
20	family	family	NN	NN	_	21	compound	_	_
21	primers	primer	NNS	NNS	_	17	dobj	_	_
22	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	zinc-finger	zinc-finger	JJ	JJ	_	3	amod	_	_
3	primers	primer	NNS	NNS	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	0	root	_	_
5	three	three	CD	CD	_	7	nummod	_	_
6	zinc-finger	zinc-finger	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	4	dobj	_	_
8	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	suggested	suggest	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	clones	clone	NNS	NNS	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	each	each	DT	DT	_	15	det	_	_
15	group	group	NN	NN	_	12	nmod	_	_
16	at	at	IN	IN	_	17	case	_	_
17	neutrophil	neutrophil	NN	NN	_	15	nmod	_	_
18	commitment	commitment	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	maturation	maturation	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	differential	differential	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	genes	gene	NNS	NNS	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	zinc	zinc	NN	NN	_	10	compound	_	_
10	finger	finger	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	POU	pou	NN	NN	_	13	compound	_	_
13	families	family	NNS	NNS	_	6	conj	_	_
14	will	will	MD	MD	_	15	aux	_	_
15	lead	lead	VB	VB	_	0	root	_	_
16	to	to	TO	TO	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	better	better	JJR	JJR	_	19	amod	_	_
19	understanding	understanding	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cascade	cascade	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	occurs	occur	VBZ	VBZ	_	25	acl:relcl	_	_
28	following	follow	VBG	VBG	_	30	case	_	_
29	ATRA-induced	atra-induced	JJ	JJ	_	30	amod	_	_
30	differentiation	differentiation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	15	punct	_	_

1	Relationship	relationship	NN	NN	_	0	root	_	_
2	between	between	IN	IN	_	5	case	_	_
3	IkappaBalpha	ikappabalpha	NN	NN	_	5	compound	_	_
4	constitutive	constitutive	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	1	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	TNFalpha	tnfalpha	NN	NN	_	8	compound	_	_
8	synthesis	synthesis	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	EBV-infected	ebv-infected	JJ	JJ	_	15	amod	_	_
14	lymphoblastoid	lymphoblastoid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	understand	understand	VB	VB	_	14	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	EBV	ebv	NN	NN	_	11	compound	_	_
11	transformation	transformation	NN	NN	_	6	nmod	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	established	establish	VBN	VBN	_	0	root	_	_
15	stably	stably	RB	RB	_	16	advmod	_	_
16	transfected	transfect	VBN	VBN	_	17	amod	_	_
17	IkappaBalpha	ikappabalpha	NN	NN	_	14	dobj	_	_
18	into	into	IN	IN	_	20	case	_	_
19	lymphoblastoid	lymphoblastoid	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	clones	clone	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	13	nmod	_	_
7	the	the	DT	DT	_	8	det	_	_
8	loss	loss	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	correlated	correlate	VBD	VBD	_	4	dobj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	transgenic	transgenic	JJ	JJ	_	21	amod	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	latency	latency	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	determined	determine	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	immunocytochemistry	immunocytochemistry	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	23	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	surface	surface	NN	NN	_	4	compound	_	_
4	markers	marker	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	intracytoplasmic	intracytoplasmic	JJ	JJ	_	7	amod	_	_
7	content	content	NN	NN	_	1	conj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	cytokines	cytokine	NNS	NNS	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	cycle	cycle	NN	NN	_	12	compound	_	_
12	analysis	analysis	NN	NN	_	7	nmod	_	_
13	after	after	IN	IN	_	15	case	_	_
14	BrdU	brdu	NN	NN	_	15	compound	_	_
15	incorporation	incorporation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	1	cc	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	staining	staining	NN	NN	_	1	conj	_	_
19	with	with	IN	IN	_	21	case	_	_
20	propidium	propidium	NN	NN	_	21	compound	_	_
21	iodide	iodide	NN	NN	_	18	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	studied	study	VBN	VBN	_	0	root	_	_
24	by	by	IN	IN	_	26	case	_	_
25	flow	flow	NN	NN	_	26	compound	_	_
26	cytometry	cytometry	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	23	punct	_	_

1	Percentage	percentage	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	apoptotic	apoptotic	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	determined	determine	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	in-situ	in-situ	FW	FW	_	9	compound	_	_
9	labelling	labelling	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	strand	strand	NN	NN	_	13	compound	_	_
13	breaks	break	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	significative	significative	JJ	JJ	_	3	amod	_	_
3	changes	change	NNS	NNS	_	14	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	EBV	ebv	NN	NN	_	6	compound	_	_
6	latency	latency	NN	NN	_	3	nmod	_	_
7	nor	nor	CC	CC	_	6	cc	_	_
8	in	in	IN	IN	_	12	case	_	_
9	cell	cell	NN	NN	_	12	compound	_	_
10	surface	surface	NN	NN	_	12	compound	_	_
11	marker	marker	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	6	conj	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	intracytoplasmic	intracytoplasmic	JJ	JJ	_	6	amod	_	_
5	TNFalpha	tnfalpha	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	strongly	strongly	RB	RB	_	9	advmod	_	_
9	reduced	reduce	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	transfected	transfect	VBN	VBN	_	12	amod	_	_
12	clones	clone	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	30	30	CD	CD	_	4	nummod	_	_
4	%	%	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IkappaBalpha	ikappabalpha	NN	NN	_	8	compound	_	_
7	transfected	transfected	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	apoptotic	apoptotic	JJ	JJ	_	0	root	_	_
11	after	after	IN	IN	_	13	case	_	_
12	8	8	CD	CD	_	13	nummod	_	_
13	h	h	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	TNFalpha	tnfalpha	NN	NN	_	16	compound	_	_
16	treatment	treatment	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	correlated	correlate	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	strong	strong	JJ	JJ	_	6	amod	_	_
6	reduction	reduction	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	BrdU	brdu	NN	NN	_	9	compound	_	_
9	incorporation	incorporation	NN	NN	_	6	nmod	_	_
10	after	after	IN	IN	_	12	case	_	_
11	24	24	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNFalpha	tnfalpha	NN	NN	_	15	compound	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	effect	effect	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	seen	see	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	non	non	JJ	JJ	_	7	amod	_	_
7	transfected	transfected	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	with	with	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	transfected	transfect	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	control	control	JJ	JJ	_	16	amod	_	_
16	plasmid	plasmid	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	TNFalpha	tnfalpha	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	10	nsubj	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	one	one	CD	CD	_	3	ccomp	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	targets	target	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	EBV	ebv	NN	NN	_	18	nmod:npmod	_	_
18	infected	infected	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	and	and	CC	CC	_	10	cc	_	_
21	that	that	IN	IN	_	23	mark	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	nsubj	_	_
23	protects	protect	VBZ	VBZ	_	10	conj	_	_
24	EBV-infected	ebv-infected	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	23	dobj	_	_
26	from	from	IN	IN	_	27	case	_	_
27	apoptosis	apoptosis	NN	NN	_	23	nmod	_	_
28	induced	induce	VBN	VBN	_	27	acl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	TNFalpha	tnfalpha	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	which	which	WDT	WDT	_	34	nsubj	_	_
33	may	may	MD	MD	_	34	aux	_	_
34	favour	favour	VB	VB	_	30	acl:relcl	_	_
35	the	the	DT	DT	_	37	det	_	_
36	proliferative	proliferative	JJ	JJ	_	37	amod	_	_
37	effect	effect	NN	NN	_	34	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	this	this	DT	DT	_	40	det	_	_
40	cytokine	cytokine	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	Signalling	signalling	NN	NN	_	0	root	_	_
2	into	into	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	nucleus	nucleus	NN	NN	_	1	nmod	_	_
6	:	:	:	:	_	1	punct	_	_
7	NFAT	nfat	NN	NN	_	8	compound	_	_
8	regulation	regulation	NN	NN	_	1	dep	_	_
9	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
3	factor	factor	NN	NN	_	7	compound	_	_
4	of	of	IN	IN	_	7	amod	_	_
5	activated	activate	VBN	VBN	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	11	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NFAT	nfat	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	plays	play	VBZ	VBZ	_	0	root	_	_
12	an	a	DT	DT	_	14	det	_	_
13	important	important	JJ	JJ	_	14	amod	_	_
14	role	role	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	biology	biology	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	results	result	VBZ	VBZ	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	rapid	rapid	JJ	JJ	_	10	amod	_	_
9	calcineurin-dependent	calcineurin-dependent	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	NFAT	nfat	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	nucleus	nucleus	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	translocation	translocation	NN	NN	_	3	compound	_	_
3	process	process	NN	NN	_	17	nsubj	_	_
4	coupled	couple	VBN	VBN	_	3	acl	_	_
5	to	to	TO	TO	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	subsequent	subsequent	JJ	JJ	_	9	amod	_	_
8	active	active	JJ	JJ	_	9	amod	_	_
9	maintenance	maintenance	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NFAT	nfat	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	nucleus	nucleus	NN	NN	_	15	compound	_	_
15	compartment	compartment	NN	NN	_	3	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	critical	critical	JJ	JJ	_	0	root	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	induction	induction	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	expression	expression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	several	several	JJ	JJ	_	25	amod	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	encoding	encode	VBG	VBG	_	25	acl	_	_
27	cytokines	cytokine	NNS	NNS	_	26	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	membrane	membrane	NN	NN	_	30	compound	_	_
30	proteins	protein	NNS	NNS	_	27	conj	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	modulate	modulate	VBP	VBP	_	27	acl:relcl	_	_
33	immune	immune	JJ	JJ	_	34	amod	_	_
34	responses	response	NNS	NNS	_	32	dobj	_	_
35	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	cloning	cloning	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	NFAT	nfat	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	has	have	VBZ	VBZ	_	12	aux	_	_
12	facilitated	facilitate	VBN	VBN	_	0	root	_	_
13	rapid	rapid	JJ	JJ	_	14	amod	_	_
14	progress	progress	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	understanding	understanding	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	signalling	signalling	NN	NN	_	21	compound	_	_
21	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
22	that	that	WDT	WDT	_	23	nsubj	_	_
23	control	control	VBP	VBP	_	21	acl:relcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	activity	activity	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	NFAT	nfat	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	Uncoupling	uncouple	VBG	VBG	_	4	amod	_	_
2	activation-dependent	activation-dependent	JJ	JJ	_	4	amod	_	_
3	HS1	hs1	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	0	root	_	_
5	from	from	IN	IN	_	13	case	_	_
6	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
7	factor	factor	NN	NN	_	11	compound	_	_
8	of	of	IN	IN	_	11	amod	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	13	compound	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	4	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	Jurkat	jurkat	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	4	nmod	_	_
18	:	:	:	:	_	4	punct	_	_
19	differential	differential	JJ	JJ	_	20	amod	_	_
20	signaling	signaling	NN	NN	_	4	dep	_	_
21	through	through	IN	IN	_	22	case	_	_
22	CD3	cd3	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	costimulatory	costimulatory	JJ	JJ	_	26	amod	_	_
26	receptors	receptor	NNS	NNS	_	22	conj	_	_
27	CD2	cd2	NN	NN	_	26	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD28	cd28	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	CD3	cd3	NN	NN	_	10	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	CD2	cd2	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	CD28	cd28	NN	NN	_	1	conj	_	_
7	are	be	VBP	VBP	_	10	cop	_	_
8	functionally	functionally	RB	RB	_	9	advmod	_	_
9	distinct	distinct	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	10	punct	_	_

1	Engagement	engagement	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	any	any	DT	DT	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	receptors	receptor	NNS	NNS	_	3	nmod	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	rapid	rapid	JJ	JJ	_	11	amod	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	phosphorylation	phosphorylation	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	shared	shared	JJ	JJ	_	15	amod	_	_
15	group	group	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	intracellular	intracellular	JJ	JJ	_	19	amod	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	22	case	_	_
22	Vav	vav	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	Cbl	cbl	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	p85	p85	NN	NN	_	28	compound	_	_
27	phosphoinositide	phosphoinositide	NN	NN	_	28	compound	_	_
28	3-kinase	3-kinase	NN	NN	_	22	conj	_	_
29	,	,	,	,	_	22	punct	_	_
30	and	and	CC	CC	_	22	cc	_	_
31	the	the	DT	DT	_	34	det	_	_
32	Src	src	NN	NN	_	34	compound	_	_
33	family	family	NN	NN	_	34	compound	_	_
34	kinases	kinase	NNS	NNS	_	22	conj	_	_
35	Lck	lck	NN	NN	_	34	dep	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	Fyn	fyn	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	7	punct	_	_

1	Ligation	ligation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD3	cd3	NN	NN	_	1	nmod	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	HS1	hs1	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	18	det	_	_
13	75-kDa	75-kda	JJ	JJ	_	18	amod	_	_
14	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
15	cell-specific	cell-specific	JJ	JJ	_	18	amod	_	_
16	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	10	appos	_	_
19	of	of	IN	IN	_	21	case	_	_
20	unknown	unknown	JJ	JJ	_	21	amod	_	_
21	function	function	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	changes	change	NNS	NNS	_	3	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	HS1	hs1	NN	NN	_	7	compound	_	_
7	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
8	after	after	IN	IN	_	10	case	_	_
9	differential	differential	JJ	JJ	_	10	amod	_	_
10	stimulation	stimulation	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD3	cd3	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	CD2	cd2	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	CD28	cd28	NN	NN	_	12	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	elucidate	elucidate	VB	VB	_	3	dep	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	further	further	RB	RB	_	28	advmod	_	_
28	delineate	delineate	VB	VB	_	19	conj	_	_
29	the	the	DT	DT	_	31	det	_	_
30	signaling	signaling	NN	NN	_	31	compound	_	_
31	pathways	pathway	NNS	NNS	_	28	dobj	_	_
32	recruited	recruit	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	receptors	receptor	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	ligation	ligation	NN	NN	_	22	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CD3	cd3	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	22	punct	_	_
6	stimulation	stimulation	NN	NN	_	22	nsubj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	anti-CD28	anti-cd28	JJ	JJ	_	9	amod	_	_
9	mAb	mab	NN	NN	_	6	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	CHO	cho	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	conj	_	_
13	expressing	express	VBG	VBG	_	9	acl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CD28	cd28	NN	NN	_	16	compound	_	_
16	ligands	ligand	NNS	NNS	_	13	dobj	_	_
17	CD80	cd80	NN	NN	_	16	dep	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	CD86	cd86	NN	NN	_	17	conj	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	lead	lead	VB	VB	_	0	root	_	_
23	to	to	TO	TO	_	25	case	_	_
24	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
25	phosphorylation	phosphorylation	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HS1	hs1	NN	NN	_	25	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	Jurkat	jurkat	NN	NN	_	31	compound	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	22	punct	_	_

1	Additionally	additionally	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HS1	hs1	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	mitogenic	mitogenic	JJ	JJ	_	12	amod	_	_
12	pairs	pair	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	anti-CD2	anti-cd2	JJ	JJ	_	15	amod	_	_
15	mAbs	mab	NNS	NNS	_	12	nmod	_	_
16	capable	capable	JJ	JJ	_	12	amod	_	_
17	of	of	IN	IN	_	18	mark	_	_
18	activating	activate	VBG	VBG	_	16	advcl	_	_
19	the	the	DT	DT	_	22	det	_	_
20	transcription	transcription	NN	NN	_	22	compound	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	NFAT	nfat	NN	NN	_	18	dobj	_	_
23	(	(	-LRB-	-LRB-	_	29	punct	_	_
24	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
25	factor	factor	NN	NN	_	29	compound	_	_
26	of	of	IN	IN	_	29	amod	_	_
27	activated	activate	VBN	VBN	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	22	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	9	punct	_	_

1	Costimulation	costimulation	NN	NN	_	8	nsubj	_	_
2	through	through	IN	IN	_	3	case	_	_
3	CD28	cd28	NN	NN	_	1	nmod	_	_
4	and/or	and/or	CC	CC	_	3	cc	_	_
5	CD2	cd2	NN	NN	_	3	conj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	modulate	modulate	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CD3-dependent	cd3-dependent	JJ	JJ	_	11	amod	_	_
11	phosphorylation	phosphorylation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	HS1	hs1	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	4	nsubj	_	_
4	indicated	indicate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	CD3-induced	cd3-induced	JJ	JJ	_	8	amod	_	_
7	HSI	hsi	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	10	nsubj	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	4	ccomp	_	_
11	upon	upon	IN	IN	_	18	case	_	_
12	both	both	CC	CC	_	18	cc:preconj	_	_
13	the	the	DT	DT	_	18	det	_	_
14	Src	src	NN	NN	_	18	compound	_	_
15	family	family	NN	NN	_	18	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	Lck	lck	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
22	phosphatase	phosphatase	NN	NN	_	23	compound	_	_
23	CD45	cd45	NN	NN	_	18	conj	_	_
24	,	,	,	,	_	10	punct	_	_
25	did	do	VBD	VBD	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	require	require	VB	VB	_	10	conj	_	_
28	MEK1	mek1	NN	NN	_	30	compound	_	_
29	kinase	kinase	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	27	dobj	_	_
31	,	,	,	,	_	10	punct	_	_
32	and	and	CC	CC	_	10	cc	_	_
33	was	be	VBD	VBD	_	34	auxpass	_	_
34	regulated	regulate	VBN	VBN	_	10	conj	_	_
35	by	by	IN	IN	_	39	case	_	_
36	protein	protein	NN	NN	_	39	compound	_	_
37	kinase	kinase	NN	NN	_	39	compound	_	_
38	C	c	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	34	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	although	although	IN	IN	_	10	mark	_	_
4	CD3	cd3	NN	NN	_	10	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	CD28	cd28	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	CD2	cd2	NN	NN	_	4	conj	_	_
10	activate	activate	VBP	VBP	_	19	advcl	_	_
11	many	many	JJ	JJ	_	10	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	same	same	JJ	JJ	_	16	amod	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	molecules	molecule	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	they	they	PRP	PRP	_	19	nsubj	_	_
19	differed	differ	VBD	VBD	_	0	root	_	_
20	in	in	IN	IN	_	22	case	_	_
21	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
22	capacity	capacity	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	induce	induce	VB	VB	_	22	acl	_	_
25	the	the	DT	DT	_	27	det	_	_
26	tyrosine	tyrosine	NN	NN	_	27	compound	_	_
27	phosphorylation	phosphorylation	NN	NN	_	24	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	HSI	hsi	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	19	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	activation-dependent	activation-dependent	JJ	JJ	_	5	amod	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HS1	hs1	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	NFAT	nfat	NN	NN	_	14	compound	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	mouse	mouse	NN	NN	_	0	root	_	_
3	carrying	carry	VBG	VBG	_	2	acl	_	_
4	genetic	genetic	JJ	JJ	_	5	amod	_	_
5	defect	defect	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	choice	choice	NN	NN	_	3	nmod	_	_
9	between	between	IN	IN	_	13	case	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	B	b	NN	NN	_	10	conj	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Transgenic	transgenic	JJ	JJ	_	2	amod	_	_
2	mice	mouse	NNS	NNS	_	9	nsubjpass	_	_
3	with	with	IN	IN	_	6	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	CD3epsilon	cd3epsilon	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	shown	show	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	exhibit	exhibit	VB	VB	_	9	xcomp	_	_
12	early	early	JJ	JJ	_	13	amod	_	_
13	arrest	arrest	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	thymus	thymus	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	shows	show	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	,	,	,	,	_	15	punct	_	_
7	instead	instead	RB	RB	_	10	case	_	_
8	of	of	IN	IN	_	7	mwe	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	15	nmod	_	_
11	,	,	,	,	_	15	punct	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	generated	generate	VBN	VBN	_	4	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	thymus	thymus	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	a	a	DT	DT	_	21	det	_	_
21	line	line	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	tg	tg	NN	NN	_	24	compound	_	_
24	epsilon26	epsilon26	NN	NN	_	21	appos	_	_
25	,	,	,	,	_	21	punct	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	human	human	JJ	JJ	_	31	amod	_	_
29	CD3epsilon	cd3epsilon	NN	NN	_	31	compound	_	_
30	transgenic	transgenic	JJ	JJ	_	31	amod	_	_
31	mice	mouse	NNS	NNS	_	21	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	accumulation	accumulation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	mature	mature	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	thymus	thymus	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	only	only	RB	RB	_	16	advmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	tg	tg	NN	NN	_	16	compound	_	_
15	epsilon26	epsilon26	NN	NN	_	16	compound	_	_
16	mice	mouse	NNS	NNS	_	11	advcl	_	_
17	,	,	,	,	_	16	punct	_	_
18	not	not	RB	RB	_	25	neg	_	_
19	in	in	IN	IN	_	25	case	_	_
20	other	other	JJ	JJ	_	25	amod	_	_
21	human	human	JJ	JJ	_	25	amod	_	_
22	CD3epsilon	cd3epsilon	NN	NN	_	25	compound	_	_
23	transgenic	transgenic	JJ	JJ	_	25	amod	_	_
24	mouse	mouse	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	16	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	other	other	JJ	JJ	_	30	amod	_	_
28	T	t	NN	NN	_	29	nmod:npmod	_	_
29	cell-deficient	cell-deficient	JJ	JJ	_	30	amod	_	_
30	mice	mouse	NNS	NNS	_	25	conj	_	_
31	,	,	,	,	_	30	punct	_	_
32	including	include	VBG	VBG	_	35	case	_	_
33	CD3-epsilon	cd3-epsilon	NN	NN	_	35	compound	_	_
34	knockout	knockout	JJ	JJ	_	35	amod	_	_
35	mice	mouse	NNS	NNS	_	30	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	TCR-beta/TCR-delta	tcr-beta/tcr-delta	NN	NN	_	40	compound	_	_
38	double	double	JJ	JJ	_	40	amod	_	_
39	knockout	knockout	JJ	JJ	_	40	amod	_	_
40	mice	mouse	NNS	NNS	_	35	conj	_	_
41	.	.	.	.	_	11	punct	_	_

1	Hanging	hang	VBG	VBG	_	3	amod	_	_
2	drop-mediated	drop-mediated	JJ	JJ	_	3	amod	_	_
3	transfer	transfer	NN	NN	_	8	nsubj	_	_
4	into	into	IN	IN	_	7	case	_	_
5	2-deoxyguanosine-treated	2-deoxyguanosine-treated	JJ	JJ	_	7	amod	_	_
6	thymus	thymus	NN	NN	_	7	compound	_	_
7	lobes	lobe	NNS	NNS	_	3	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	19	mark	_	_
10	lymphoid	lymphoid	JJ	JJ	_	12	amod	_	_
11	progenitor	progenitor	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	19	nsubj	_	_
13	rather	rather	RB	RB	_	12	cc	_	_
14	than	than	IN	IN	_	13	mwe	_	_
15	thymus	thymus	NN	NN	_	17	compound	_	_
16	stromal	stromal	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	conj	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	responsible	responsible	JJ	JJ	_	8	ccomp	_	_
20	for	for	IN	IN	_	24	case	_	_
21	abnormal	abnormal	JJ	JJ	_	24	amod	_	_
22	B	b	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	tg	tg	NN	NN	_	28	compound	_	_
27	epsilon26	epsilon26	NN	NN	_	28	compound	_	_
28	thymus	thymus	NN	NN	_	19	nmod	_	_
29	,	,	,	,	_	19	punct	_	_
30	and	and	CC	CC	_	19	cc	_	_
31	that	that	IN	IN	_	38	mark	_	_
32	tg	tg	NN	NN	_	36	compound	_	_
33	epsilon26	epsilon26	NN	NN	_	36	compound	_	_
34	fetal	fetal	JJ	JJ	_	36	amod	_	_
35	liver	liver	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	38	nsubjpass	_	_
37	were	be	VBD	VBD	_	38	auxpass	_	_
38	destined	destine	VBN	VBN	_	19	conj	_	_
39	to	to	TO	TO	_	40	mark	_	_
40	become	become	VB	VB	_	38	xcomp	_	_
41	B	b	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	40	xcomp	_	_
43	in	in	IN	IN	_	45	case	_	_
44	normal	normal	JJ	JJ	_	45	amod	_	_
45	thymus	thymus	NN	NN	_	40	nmod	_	_
46	even	even	RB	RB	_	53	advmod	_	_
47	in	in	IN	IN	_	53	case	_	_
48	the	the	DT	DT	_	53	dep	_	_
49	presence	presence	NN	NN	_	53	dep	_	_
50	of	of	IN	IN	_	53	case	_	_
51	normal	normal	JJ	JJ	_	53	amod	_	_
52	progenitor	progenitor	NN	NN	_	53	compound	_	_
53	cells	cell	NNS	NNS	_	40	nmod	_	_
54	undergoing	undergo	VBG	VBG	_	53	acl	_	_
55	T	t	NN	NN	_	57	compound	_	_
56	cell	cell	NN	NN	_	57	compound	_	_
57	development	development	NN	NN	_	54	dobj	_	_
58	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
6	progenitor	progenitor	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	14	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	tg	tg	NN	NN	_	11	compound	_	_
10	epsilon26	epsilon26	NN	NN	_	11	compound	_	_
11	mice	mouse	NNS	NNS	_	7	nmod	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	genetically	genetically	RB	RB	_	14	advmod	_	_
14	defective	defective	JJ	JJ	_	3	ccomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	thymic	thymic	JJ	JJ	_	17	amod	_	_
17	choice	choice	NN	NN	_	14	nmod	_	_
18	between	between	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	generating	generate	VBG	VBG	_	14	xcomp	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	25	dobj	_	_
28	even	even	RB	RB	_	32	advmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	normal	normal	JJ	JJ	_	32	amod	_	_
31	thymus	thymus	NN	NN	_	32	compound	_	_
32	environment	environment	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	tg	tg	NN	NN	_	5	compound	_	_
4	epsilon26	epsilon26	NN	NN	_	5	compound	_	_
5	thymocytes	thymocyte	NNS	NNS	_	6	nsubj	_	_
6	expressed	express	VBD	VBD	_	0	root	_	_
7	GATA-3	gata-3	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	TCF-1	tcf-1	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	7	cc	_	_
13	LEF-1	lef-1	NN	NN	_	7	conj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	PEBP-2alpha	pebp-2alpha	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	among	among	IN	IN	_	21	case	_	_
18	T	t	NN	NN	_	21	compound	_	_
19	cell-specific	cell-specific	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	6	nmod	_	_
22	that	that	WDT	WDT	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	involved	involve	VBN	VBN	_	21	acl:relcl	_	_
25	in	in	IN	IN	_	29	case	_	_
26	early	early	JJ	JJ	_	29	amod	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	development	development	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	6	punct	_	_
31	indicating	indicate	VBG	VBG	_	6	advcl	_	_
32	that	that	IN	IN	_	43	mark	_	_
33	GATA-3	gata-3	NN	NN	_	43	nsubj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	TCF-1	tcf-1	NN	NN	_	33	conj	_	_
36	expressed	express	VBN	VBN	_	33	acl	_	_
37	during	during	IN	IN	_	39	case	_	_
38	thymocyte	thymocyte	NN	NN	_	39	compound	_	_
39	development	development	NN	NN	_	36	nmod	_	_
40	do	do	VBP	VBP	_	43	aux	_	_
41	not	not	RB	RB	_	43	neg	_	_
42	necessarily	necessarily	RB	RB	_	43	advmod	_	_
43	determine	determine	VB	VB	_	31	ccomp	_	_
44	the	the	DT	DT	_	46	det	_	_
45	cell	cell	NN	NN	_	46	compound	_	_
46	fate	fate	NN	NN	_	43	dobj	_	_
47	into	into	IN	IN	_	50	case	_	_
48	T	t	NN	NN	_	50	compound	_	_
49	cell	cell	NN	NN	_	50	compound	_	_
50	lineage	lineage	NN	NN	_	43	nmod	_	_
51	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	tg	tg	NN	NN	_	5	compound	_	_
4	epsilon26	epsilon26	NN	NN	_	5	compound	_	_
5	mice	mouse	NNS	NNS	_	6	nsubj	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	novel	novel	JJ	JJ	_	10	amod	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	model	model	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	22	mark	_	_
12	that	that	IN	IN	_	22	mark	_	_
13	lineage	lineage	NN	NN	_	14	compound	_	_
14	choice	choice	NN	NN	_	22	nsubj	_	_
15	between	between	IN	IN	_	19	case	_	_
16	T	t	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	B	b	NN	NN	_	16	conj	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	genetically	genetically	RB	RB	_	22	advmod	_	_
22	defective	defective	JJ	JJ	_	6	advcl	_	_
23	.	.	.	.	_	6	punct	_	_

1	IL-7	il-7	NN	NN	_	2	nsubj	_	_
2	reconstitutes	reconstitute	VBZ	VBZ	_	0	root	_	_
3	multiple	multiple	JJ	JJ	_	4	amod	_	_
4	aspects	aspect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	v-Abl-mediated	v-abl-mediated	JJ	JJ	_	7	amod	_	_
7	signaling	signaling	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	15	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	10	nmod	_	_
5	early	early	JJ	JJ	_	7	amod	_	_
6	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	selectively	selectively	RB	RB	_	10	advmod	_	_
10	transformed	transform	VBN	VBN	_	2	acl:relcl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	v-Abl	v-abl	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	currently	currently	RB	RB	_	15	advmod	_	_
15	unknown	unknown	JJ	JJ	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	IL-4	il-4	NN	NN	_	12	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	IL-7	il-7	NN	NN	_	8	conj	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	measured	measure	VBN	VBN	_	4	advcl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	Janus	janus	NN	NN	_	23	compound	_	_
20	protein	protein	NN	NN	_	23	compound	_	_
21	kinase	kinase	NN	NN	_	23	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	JAK	jak	NN	NN	_	17	nmod	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	1	1	CD	CD	_	23	nummod	_	_
26	,	,	,	,	_	23	punct	_	_
27	JAK3	jak3	NN	NN	_	23	conj	_	_
28	,	,	,	,	_	23	punct	_	_
29	STAT5	stat5	NN	NN	_	23	conj	_	_
30	,	,	,	,	_	23	punct	_	_
31	and	and	CC	CC	_	23	cc	_	_
32	STAT6	stat6	NN	NN	_	23	conj	_	_
33	,	,	,	,	_	17	punct	_	_
34	in	in	IN	IN	_	36	case	_	_
35	pre-B	pre-b	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	17	nmod	_	_
37	transformed	transform	VBN	VBN	_	36	acl	_	_
38	by	by	IN	IN	_	39	case	_	_
39	v-Abl	v-abl	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	42	advcl	_	_
3	whether	whether	IN	IN	_	13	mark	_	_
4	activation	activation	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	these	these	DT	DT	_	9	det	_	_
7	cytokine	cytokine	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	4	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	v-Abl	v-abl	NN	NN	_	4	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	important	important	JJ	JJ	_	2	ccomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	events	event	NNS	NNS	_	13	nmod	_	_
18	induced	induce	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	Abelson	abelson	NN	NN	_	24	compound	_	_
22	murine	murine	JJ	JJ	_	24	amod	_	_
23	leukemia	leukemia	NN	NN	_	24	compound	_	_
24	virus	virus	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	42	punct	_	_
26	the	the	DT	DT	_	27	det	_	_
27	effects	effect	NNS	NNS	_	42	nsubjpass	_	_
28	of	of	IN	IN	_	29	case	_	_
29	IL-4	il-4	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	IL-7	il-7	NN	NN	_	29	conj	_	_
32	on	on	IN	IN	_	34	case	_	_
33	pre-B	pre-b	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	27	nmod	_	_
35	transformed	transform	VBN	VBN	_	34	acl	_	_
36	with	with	IN	IN	_	40	case	_	_
37	a	a	DT	DT	_	40	det	_	_
38	temperature-sensitive	temperature-sensitive	JJ	JJ	_	40	amod	_	_
39	v-Abl	v-abl	NN	NN	_	40	compound	_	_
40	mutant	mutant	NN	NN	_	35	nmod	_	_
41	were	be	VBD	VBD	_	42	auxpass	_	_
42	examined	examine	VBN	VBN	_	0	root	_	_
43	.	.	.	.	_	42	punct	_	_

1	Whereas	whereas	IN	IN	_	3	mark	_	_
2	IL-4	il-4	NN	NN	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	10	advcl	_	_
4	little	little	JJ	JJ	_	3	dobj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	no	no	DT	DT	_	4	conj	_	_
7	effect	effect	NN	NN	_	4	dep	_	_
8	,	,	,	,	_	10	punct	_	_
9	IL-7	il-7	NN	NN	_	10	nsubj	_	_
10	delayed	delay	VBD	VBD	_	0	root	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	the	the	DT	DT	_	13	dep	_	_
13	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	cycle	cycle	NN	NN	_	17	compound	_	_
17	arrest	arrest	NN	NN	_	13	conj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	occur	occur	VBP	VBP	_	13	acl:relcl	_	_
20	upon	upon	IN	IN	_	23	case	_	_
21	v-Abl	v-abl	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	inactivation	inactivation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	IL-7	il-7	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	delayed	delay	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	decreases	decrease	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	levels	level	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	c-Myc	c-myc	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	Bcl-2	bcl-2	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	Bcl-xL	bcl-xl	NN	NN	_	10	conj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	occur	occur	VBP	VBP	_	10	acl:relcl	_	_
18	upon	upon	IN	IN	_	19	case	_	_
19	loss	loss	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	v-Abl	v-abl	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	IL-7	il-7	NN	NN	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	maintain	maintain	VB	VB	_	0	root	_	_
5	v-Abl-mediated	v-abl-mediated	JJ	JJ	_	7	amod	_	_
6	differentiation	differentiation	NN	NN	_	7	compound	_	_
7	arrest	arrest	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	pre-B	pre-b	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	as	as	IN	IN	_	22	mark	_	_
14	activation	activation	NN	NN	_	22	nsubj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	RAG	rag	NN	NN	_	16	conj	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	14	nmod	_	_
21	was	be	VBD	VBD	_	22	aux	_	_
22	unaffected	unaffected	JJ	JJ	_	4	advcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	IL-7	il-7	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	IL-7	il-7	NN	NN	_	10	compound	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	transformation	transformation	NN	NN	_	6	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	v-Abl	v-abl	NN	NN	_	12	nmod	_	_
15	while	while	IN	IN	_	16	mark	_	_
16	demonstrating	demonstrate	VBG	VBG	_	3	advcl	_	_
17	that	that	IN	IN	_	27	mark	_	_
18	a	a	DT	DT	_	19	det	_	_
19	combination	combination	NN	NN	_	27	nsubj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	IL-4	il-4	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IL-7	il-7	NN	NN	_	21	conj	_	_
24	signaling	signaling	NN	NN	_	19	nmod	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	substitute	substitute	VB	VB	_	16	ccomp	_	_
28	for	for	IN	IN	_	32	case	_	_
29	an	a	DT	DT	_	32	det	_	_
30	active	active	JJ	JJ	_	32	amod	_	_
31	v-Abl	v-abl	NN	NN	_	32	compound	_	_
32	kinase	kinase	NN	NN	_	27	nmod	_	_
33	in	in	IN	IN	_	36	case	_	_
34	transformed	transform	VBN	VBN	_	36	amod	_	_
35	pre-B	pre-b	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	protein	protein	NN	NN	_	7	compound	_	_
5	kinase	kinase	NN	NN	_	7	compound	_	_
6	C	c	NN	NN	_	7	compound	_	_
7	signaling	signaling	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	DRA	dra	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	8	case	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	MHC	mhc	NN	NN	_	8	compound	_	_
5	HLA-DRA	hla-dra	NN	NN	_	8	compound	_	_
6	class	class	NN	NN	_	8	compound	_	_
7	II	ii	CD	CD	_	8	nummod	_	_
8	gene	gene	NN	NN	_	1	nmod	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	Ig	ig	NN	NN	_	17	compound	_	_
17	cross-linking	cross-linking	NN	NN	_	11	nmod	_	_
18	as	as	RB	RB	_	17	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	by	by	IN	IN	_	23	case	_	_
22	phorbol	phorbol	NN	NN	_	23	compound	_	_
23	esters	ester	NNS	NNS	_	17	conj	_	_
24	such	such	JJ	JJ	_	28	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	28	compound	_	_
27	phorbol	phorbol	NN	NN	_	28	compound	_	_
28	13-acetate	13-acetate	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TPA	tpa	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	11	punct	_	_

1	Induced	induce	VBN	VBN	_	3	amod	_	_
2	DRA	dra	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	involves	involve	VBZ	VBZ	_	0	root	_	_
5	activation	activation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	14	case	_	_
7	restricted	restricted	JJ	JJ	_	14	amod	_	_
8	protein	protein	NN	NN	_	14	compound	_	_
9	kinase	kinase	NN	NN	_	14	compound	_	_
10	C	c	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	PKC	pkc	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	isoforms	isoform	NNS	NNS	_	5	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	resulting	result	VBG	VBG	_	4	advcl	_	_
17	in	in	IN	IN	_	21	case	_	_
18	activated	activate	VBN	VBN	_	21	amod	_	_
19	activator	activator	NN	NN	_	21	compound	_	_
20	protein-1-dependent	protein-1-dependent	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	11	nmod	_	_
4	expression	expression	NN	NN	_	5	compound	_	_
5	profiles	profile	NNS	NNS	_	11	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activation	activation	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PKC	pkc	NN	NN	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	Raji	raji	NN	NN	_	17	compound	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	lymphoblastoid	lymphoblastoid	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	20	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	target	target	NN	NN	_	6	compound	_	_
6	plasmids	plasmid	NNS	NNS	_	3	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	either	either	CC	CC	_	10	cc:preconj	_	_
9	DRA	dra	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	7	dobj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	wild-type	wild-type	JJ	JJ	_	10	dep	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	mutated	mutate	VBN	VBN	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	or	or	CC	CC	_	10	cc	_	_
17	TPA	tpa	NN	NN	_	19	compound	_	_
18	response	response	NN	NN	_	19	compound	_	_
19	elements	element	NNS	NNS	_	10	conj	_	_
20	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
21	that	that	IN	IN	_	30	mark	_	_
22	pretreatment	pretreatment	NN	NN	_	30	nsubj	_	_
23	with	with	IN	IN	_	29	case	_	_
24	the	the	DT	DT	_	29	det	_	_
25	selective	selective	JJ	JJ	_	29	amod	_	_
26	PKC	pkc	NN	NN	_	29	compound	_	_
27	inhibitor	inhibitor	NN	NN	_	29	compound	_	_
28	GF	gf	NN	NN	_	29	compound	_	_
29	109203X	109203x	NN	NN	_	22	nmod	_	_
30	repressed	repress	VBD	VBD	_	20	ccomp	_	_
31	TPA-mediated	tpa-mediated	JJ	JJ	_	32	amod	_	_
32	activation	activation	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	20	punct	_	_

1	Western	western	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	14	nsubj	_	_
3	performed	perform	VBN	VBN	_	2	acl	_	_
4	on	on	IN	IN	_	6	case	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	fractions	fraction	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	resting	rest	VBG	VBG	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	of	of	IN	IN	_	13	case	_	_
12	TPA-activated	tpa-activated	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	conj	_	_
14	revealed	reveal	VBD	VBD	_	0	root	_	_
15	abundant	abundant	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	29	case	_	_
18	classical	classical	JJ	JJ	_	19	amod	_	_
19	PKC-alpha	pkc-alpha	NN	NN	_	29	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	cPKC-alpha	cpkc-alpha	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	19	punct	_	_
24	cPKC-betaII	cpkc-betaii	NN	NN	_	19	conj	_	_
25	,	,	,	,	_	19	punct	_	_
26	and	and	CC	CC	_	19	cc	_	_
27	atypical	atypical	JJ	JJ	_	28	amod	_	_
28	PKC-zeta	pkc-zeta	NN	NN	_	19	conj	_	_
29	isoforms	isoform	NNS	NNS	_	16	nmod	_	_
30	and	and	CC	CC	_	14	cc	_	_
31	identified	identify	VBD	VBD	_	14	conj	_	_
32	a	a	DT	DT	_	34	det	_	_
33	sustained	sustained	JJ	JJ	_	34	amod	_	_
34	translocation	translocation	NN	NN	_	31	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	cPKC-alpha	cpkc-alpha	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	cPKC-betaII	cpkc-betaii	NN	NN	_	36	conj	_	_
39	from	from	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	cytosolic	cytosolic	JJ	JJ	_	42	amod	_	_
42	compartment	compartment	NN	NN	_	34	nmod	_	_
43	to	to	TO	TO	_	44	case	_	_
44	membranes	membrane	NNS	NNS	_	34	nmod	_	_
45	.	.	.	.	_	14	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	10	advcl	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	distribution	distribution	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	atypical	atypical	JJ	JJ	_	8	amod	_	_
8	PKC-zeta	pkc-zeta	NN	NN	_	5	nmod	_	_
9	was	be	VBD	VBD	_	10	aux	_	_
10	unaffected	unaffected	JJ	JJ	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	TPA	tpa	NN	NN	_	13	compound	_	_
13	treatment	treatment	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	displayed	display	VBD	VBD	_	10	conj	_	_
16	an	a	DT	DT	_	18	det	_	_
17	even	even	JJ	JJ	_	18	amod	_	_
18	distribution	distribution	NN	NN	_	15	dobj	_	_
19	between	between	IN	IN	_	20	case	_	_
20	cytosol	cytosol	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	membranes	membrane	NNS	NNS	_	20	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	confirmed	confirm	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	immunofluorescence	immunofluorescence	NN	NN	_	7	compound	_	_
7	microscopy	microscopy	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	TPA-mediated	tpa-mediated	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	cPKC-alpha	cpkc-alpha	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cPKC-betaII	cpkc-betaii	NN	NN	_	5	conj	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	influenced	influence	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	pretreatment	pretreatment	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	GF	gf	NN	NN	_	15	compound	_	_
15	109203X	109203x	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Finally	finally	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	functional	functional	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	translocation	translocation	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PKC	pkc	NN	NN	_	4	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	investigated	investigate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	17	case	_	_
12	a	a	DT	DT	_	17	det	_	_
13	selective	selective	JJ	JJ	_	17	amod	_	_
14	in	in	FW	FW	_	17	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	kinase	kinase	NN	NN	_	17	compound	_	_
17	assay	assay	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	activated	activate	VBN	VBN	_	9	amod	_	_
8	HLA-DRA	hla-dra	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	17	nsubj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	response	response	NN	NN	_	14	dep	_	_
12	to	to	TO	TO	_	14	case	_	_
13	TPA	tpa	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	9	nmod	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	strictly	strictly	RB	RB	_	17	advmod	_	_
17	dependent	dependent	JJ	JJ	_	5	ccomp	_	_
18	on	on	IN	IN	_	20	case	_	_
19	PKC	pkc	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	acting	act	VBG	VBG	_	20	acl	_	_
22	on	on	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	X2	x2	NN	NN	_	25	compound	_	_
25	box	box	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	DRA	dra	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	17	cc	_	_
31	that	that	IN	IN	_	40	mark	_	_
32	selective	selective	JJ	JJ	_	33	amod	_	_
33	inhibition	inhibition	NN	NN	_	40	nsubj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	PKC	pkc	NN	NN	_	37	compound	_	_
36	enzymatic	enzymatic	JJ	JJ	_	37	amod	_	_
37	activity	activity	NN	NN	_	33	nmod	_	_
38	does	do	VBZ	VBZ	_	40	aux	_	_
39	not	not	RB	RB	_	40	neg	_	_
40	influence	influence	VB	VB	_	17	conj	_	_
41	subcellular	subcellular	JJ	JJ	_	42	amod	_	_
42	localization	localization	NN	NN	_	40	dobj	_	_
43	of	of	IN	IN	_	46	case	_	_
44	expressed	express	VBN	VBN	_	46	amod	_	_
45	PKC	pkc	NN	NN	_	46	compound	_	_
46	isoenzymes	isoenzyme	NNS	NNS	_	42	nmod	_	_
47	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	translocation	translocation	NN	NN	_	5	compound	_	_
5	event	event	NN	NN	_	8	nsubj	_	_
6	per	per	FW	FW	_	7	compound	_	_
7	se	se	FW	FW	_	8	advmod	_	_
8	occurs	occur	VBZ	VBZ	_	0	root	_	_
9	independently	independently	RB	RB	_	8	advmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	PKC	pkc	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Attenuation	attenuation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HLA-DR	hla-dr	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	phagocytes	phagocyte	NNS	NNS	_	1	nmod	_	_
8	infected	infect	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	11	case	_	_
10	Mycobacterium	mycobacterium	NN	NN	_	11	compound	_	_
11	tuberculosis	tuberculosis	NN	NN	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	related	related	JJ	JJ	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	intracellular	intracellular	JJ	JJ	_	16	amod	_	_
16	sequestration	sequestration	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	immature	immature	JJ	JJ	_	21	amod	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	heterodimers	heterodimer	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	MHC	mhc	NN	NN	_	4	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	examined	examine	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	macrophages	macrophage	NNS	NNS	_	6	nmod	_	_
9	infected	infect	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	Mycobacterium	mycobacterium	NN	NN	_	12	compound	_	_
12	tuberculosis	tuberculosis	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	surface	surface	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	class	class	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	molecules	molecule	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	THP-1	thp-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	this	this	DT	DT	_	17	nsubjpass	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	markedly	markedly	RB	RB	_	17	advmod	_	_
17	reduced	reduce	VBN	VBN	_	2	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	infected	infect	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	23	case	_	_
22	M.	m.	NN	NN	_	23	compound	_	_
23	tuberculosis	tuberculosis	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	effect	effect	NN	NN	_	20	nmod	_	_
4	,	,	,	,	_	20	punct	_	_
5	steady	steady	JJ	JJ	_	7	amod	_	_
6	state	state	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	20	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	HLA-DRalpha	hla-dralpha	NN	NN	_	11	compound	_	_
10	,	,	,	,	_	11	punct	_	_
11	HLA-DRbeta	hla-drbeta	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	invariant	invariant	JJ	JJ	_	18	amod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	Ii	ii	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	chains	chain	NNS	NNS	_	11	conj	_	_
19	were	be	VBD	VBD	_	20	cop	_	_
20	equivalent	equivalent	JJ	JJ	_	0	root	_	_
21	in	in	IN	IN	_	25	case	_	_
22	control	control	JJ	JJ	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	infected	infected	JJ	JJ	_	22	conj	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	20	punct	_	_

1	Metabolic	metabolic	JJ	JJ	_	2	amod	_	_
2	labeling	labeling	NN	NN	_	10	nsubj	_	_
3	combined	combine	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	6	case	_	_
5	pulse-chase	pulse-chase	JJ	JJ	_	6	amod	_	_
6	experiments	experiment	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	biochemical	biochemical	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	6	conj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	21	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	majority	majority	NN	NN	_	21	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	class	class	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	17	nummod	_	_
17	molecules	molecule	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	infected	infected	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	became	become	VBD	VBD	_	10	ccomp	_	_
22	resistant	resistant	JJ	JJ	_	21	xcomp	_	_
23	to	to	TO	TO	_	25	case	_	_
24	endoglycosidase	endoglycosidase	NN	NN	_	25	compound	_	_
25	H	h	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	21	punct	_	_
27	consistent	consistent	JJ	JJ	_	21	xcomp	_	_
28	with	with	IN	IN	_	31	case	_	_
29	normal	normal	JJ	JJ	_	31	amod	_	_
30	Golgi	golgi	NN	NN	_	31	compound	_	_
31	processing	processing	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	results	result	NNS	NNS	_	12	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
6	staining	staining	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	dual	dual	JJ	JJ	_	11	amod	_	_
9	color	color	NN	NN	_	11	compound	_	_
10	confocal	confocal	JJ	JJ	_	11	amod	_	_
11	microscopy	microscopy	NN	NN	_	6	conj	_	_
12	revealed	reveal	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	significant	significant	JJ	JJ	_	15	amod	_	_
15	defect	defect	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	case	_	_
17	transport	transport	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	newly	newly	RB	RB	_	20	advmod	_	_
20	synthesized	synthesize	VBN	VBN	_	23	amod	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	II	ii	CD	CD	_	23	nummod	_	_
23	molecules	molecule	NNS	NNS	_	17	nmod	_	_
24	through	through	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	endocytic	endocytic	JJ	JJ	_	27	amod	_	_
27	compartment	compartment	NN	NN	_	12	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	compared	compare	VBN	VBN	_	5	case	_	_
4	with	with	IN	IN	_	5	case	_	_
5	findings	finding	NNS	NNS	_	16	advcl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	control	control	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	molecules	molecule	NNS	NNS	_	16	nsubj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	infected	infected	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	colocalized	colocalize	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	minimal	minimal	JJ	JJ	_	20	amod	_	_
20	extent	extent	NN	NN	_	16	nmod	_	_
21	with	with	IN	IN	_	27	case	_	_
22	a	a	DT	DT	_	27	det	_	_
23	lysosomal-associated	lysosomal-associated	JJ	JJ	_	27	amod	_	_
24	membrane	membrane	NN	NN	_	27	compound	_	_
25	protein-1+	protein-1+	JJ	JJ	_	27	amod	_	_
26	endosomal	endosomal	JJ	JJ	_	27	amod	_	_
27	compartment	compartment	NN	NN	_	16	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	in	in	IN	IN	_	8	case	_	_
5	contrast	contrast	NN	NN	_	8	dep	_	_
6	to	to	TO	TO	_	8	case	_	_
7	control	control	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	16	nmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	molecules	molecule	NNS	NNS	_	16	nsubj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	infected	infected	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	failed	fail	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	colocalize	colocalize	VB	VB	_	16	xcomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	endocytosed	endocytose	VBN	VBN	_	21	amod	_	_
21	BSA	bsa	NN	NN	_	18	nmod	_	_
22	under	under	IN	IN	_	23	case	_	_
23	conditions	condition	NNS	NNS	_	18	nmod	_	_
24	where	where	WRB	WRB	_	28	advmod	_	_
25	this	this	DT	DT	_	26	det	_	_
26	marker	marker	NN	NN	_	28	nsubjpass	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	known	know	VBN	VBN	_	23	acl:relcl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	label	label	VB	VB	_	28	xcomp	_	_
31	late	late	JJ	JJ	_	32	amod	_	_
32	endosomes	endosome	NNS	NNS	_	30	dobj	_	_
33	,	,	,	,	_	32	punct	_	_
34	lysosomes	lysosome	NNS	NNS	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	the	the	DT	DT	_	41	det	_	_
38	MHC	mhc	NN	NN	_	41	compound	_	_
39	class	class	NN	NN	_	41	compound	_	_
40	II	ii	CD	CD	_	41	nummod	_	_
41	compartment	compartment	NN	NN	_	32	conj	_	_
42	.	.	.	.	_	16	punct	_	_

1	Consistent	consistent	JJ	JJ	_	41	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	defective	defective	JJ	JJ	_	4	amod	_	_
4	transport	transport	NN	NN	_	1	nmod	_	_
5	along	along	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	endocytic	endocytic	JJ	JJ	_	8	amod	_	_
8	pathway	pathway	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	41	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	maturation	maturation	NN	NN	_	41	nsubj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	SDS-stable	sds-stable	JJ	JJ	_	17	amod	_	_
14	class	class	NN	NN	_	17	compound	_	_
15	II	ii	CD	CD	_	17	nummod	_	_
16	alphabeta	alphabeta	NN	NN	_	17	compound	_	_
17	dimers	dimer	NNS	NNS	_	11	nmod	_	_
18	--	--	:	:	_	11	punct	_	_
19	dependent	dependent	JJ	JJ	_	11	amod	_	_
20	upon	upon	IN	IN	_	21	case	_	_
21	removal	removal	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	Ii	ii	NN	NN	_	24	compound	_	_
24	chain	chain	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	peptide	peptide	NN	NN	_	27	compound	_	_
27	loading	loading	NN	NN	_	21	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	class	class	NN	NN	_	31	compound	_	_
30	II	ii	CD	CD	_	31	nummod	_	_
31	dimers	dimer	NNS	NNS	_	27	nmod	_	_
32	in	in	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	MHC	mhc	NN	NN	_	37	compound	_	_
35	class	class	NN	NN	_	37	compound	_	_
36	II	ii	CD	CD	_	37	nummod	_	_
37	compartment	compartment	NN	NN	_	27	nmod	_	_
38	--	--	:	:	_	11	punct	_	_
39	was	be	VBD	VBD	_	41	aux	_	_
40	markedly	markedly	RB	RB	_	41	advmod	_	_
41	impaired	impaired	JJ	JJ	_	0	root	_	_
42	in	in	IN	IN	_	45	case	_	_
43	M.	m.	NN	NN	_	44	nmod:npmod	_	_
44	tuberculosis-infected	tuberculosis-infected	JJ	JJ	_	45	amod	_	_
45	cells	cell	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	41	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	defective	defective	JJ	JJ	_	6	amod	_	_
6	transport	transport	NN	NN	_	18	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	processing	processing	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	molecules	molecule	NNS	NNS	_	6	nmod	_	_
13	through	through	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	endosomal/lysosomal	endosomal/lysosomal	JJ	JJ	_	16	amod	_	_
16	system	system	NN	NN	_	6	nmod	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
19	for	for	IN	IN	_	23	case	_	_
20	diminished	diminish	VBN	VBN	_	23	amod	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	surface	surface	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	MHC	mhc	NN	NN	_	28	compound	_	_
26	class	class	NN	NN	_	28	compound	_	_
27	II	ii	CD	CD	_	28	nummod	_	_
28	molecules	molecule	NNS	NNS	_	23	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	cells	cell	NNS	NNS	_	23	nmod	_	_
31	infected	infect	VBN	VBN	_	30	acl	_	_
32	with	with	IN	IN	_	34	case	_	_
33	M.	m.	NN	NN	_	34	compound	_	_
34	tuberculosis	tuberculosis	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	PPARgamma	ppargamma	NN	NN	_	0	root	_	_
5	-	-	:	:	_	4	punct	_	_
6	bigger	bigger	JJR	JJR	_	4	amod	_	_
7	than	than	IN	IN	_	8	case	_	_
8	fat	fat	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Work	work	NN	NN	_	8	nsubj	_	_
2	reported	report	VBD	VBD	_	1	acl	_	_
3	over	over	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	past	past	JJ	JJ	_	6	amod	_	_
6	year	year	NN	NN	_	2	nmod	_	_
7	has	have	VBZ	VBZ	_	8	aux	_	_
8	provided	provide	VBN	VBN	_	0	root	_	_
9	insights	insight	NNS	NNS	_	8	dobj	_	_
10	into	into	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
13	whereby	whereby	WRB	WRB	_	27	advmod	_	_
14	ligand	ligand	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	27	nsubj	_	_
16	of	of	IN	IN	_	23	case	_	_
17	the	the	DT	DT	_	23	det	_	_
18	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
19	receptor	receptor	NN	NN	_	23	compound	_	_
20	peroxisome	peroxisome	NN	NN	_	23	compound	_	_
21	proliferator-activated	proliferator-activated	JJ	JJ	_	23	amod	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	gamma	gamma	NN	NN	_	15	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PPARgamma	ppargamma	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	regulates	regulate	VBZ	VBZ	_	12	acl:relcl	_	_
28	systemic	systemic	JJ	JJ	_	29	amod	_	_
29	glucose	glucose	NN	NN	_	27	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	lipid	lipid	NN	NN	_	32	compound	_	_
32	homeostasis	homeostasis	NN	NN	_	29	conj	_	_
33	.	.	.	.	_	8	punct	_	_

1	PPARgamma	ppargamma	NN	NN	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	implicated	implicate	VBN	VBN	_	0	root	_	_
6	recently	recently	RB	RB	_	5	advmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	biology	biology	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cell-cycle	cell-cycle	JJ	JJ	_	15	amod	_	_
15	regulation	regulation	NN	NN	_	9	conj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cancer	cancer	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	Polyunsaturated	polyunsaturated	JJ	JJ	_	3	amod	_	_
2	fatty	fatty	JJ	JJ	_	3	amod	_	_
3	acids	acid	NNS	NNS	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	eicosanoids	eicosanoid	NNS	NNS	_	3	conj	_	_
6	bind	bind	VBP	VBP	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	activate	activate	VBP	VBP	_	6	conj	_	_
9	PPARgamma	ppargamma	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	these	these	DT	DT	_	14	det	_	_
14	lipids	lipid	NNS	NNS	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	serve	serve	VB	VB	_	11	ccomp	_	_
17	as	as	IN	IN	_	19	case	_	_
18	hormonal	hormonal	JJ	JJ	_	19	amod	_	_
19	regulators	regulator	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	variety	variety	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	biological	biological	JJ	JJ	_	25	amod	_	_
25	processes	process	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	p21ras	p21ras	NN	NN	_	2	nsubj	_	_
2	initiates	initiate	VBZ	VBZ	_	0	root	_	_
3	Rac-1	rac-1	NN	NN	_	2	dobj	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	3	cc	_	_
6	phosphatidyl	phosphatidyl	NN	NN	_	9	compound	_	_
7	inositol	inositol	NN	NN	_	9	compound	_	_
8	3	3	CD	CD	_	9	nummod	_	_
9	kinase/PKB	kinase/pkb	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	9	punct	_	_
11	mediated	mediate	VBN	VBN	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	appos	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	p21ras	p21ras	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	activated	activate	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	T	t	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TCR	tcr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	3	cc	_	_
14	then	then	RB	RB	_	15	advmod	_	_
15	co-ordinates	co-ordinate	VBZ	VBZ	_	3	conj	_	_
16	important	important	JJ	JJ	_	18	amod	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	15	dobj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	lymphocyte	lymphocyte	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Effector	effector	NN	NN	_	2	compound	_	_
2	pathways	pathway	NNS	NNS	_	13	nsubjpass	_	_
3	for	for	IN	IN	_	8	case	_	_
4	this	this	DT	DT	_	8	det	_	_
5	guanine	guanine	NN	NN	_	8	compound	_	_
6	nucleotide	nucleotide	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	serine/threonine	serine/threonine	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	Raf-1	raf-1	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	23	det	_	_
21	Ras-related	ras-related	JJ	JJ	_	23	amod	_	_
22	GTPase	gtpase	NN	NN	_	23	compound	_	_
23	Rac-1	rac-1	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fibroblasts	fibroblast	NNS	NNS	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	effector	effector	NN	NN	_	13	nsubj	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Ras	ras	NN	NN	_	10	compound	_	_
10	oncogene	oncogene	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	Phosphatidylinositol	phosphatidylinositol	NN	NN	_	13	compound	_	_
13	3-kinase	3-kinase	NN	NN	_	0	root	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	PtdIns	ptdins	NN	NN	_	16	compound	_	_
16	3-kinase	3-kinase	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	lipid	lipid	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	able	able	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	critical	critical	JJ	JJ	_	13	amod	_	_
11	Rac-1	rac-1	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	dobj	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	couple	couple	VB	VB	_	7	conj	_	_
17	p21ras	p21ras	NN	NN	_	16	dobj	_	_
18	to	to	TO	TO	_	21	case	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	survival	survival	NN	NN	_	21	compound	_	_
21	mechanisms	mechanism	NNS	NNS	_	16	nmod	_	_
22	via	via	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	serine/threonine	serine/threonine	NN	NN	_	26	compound	_	_
25	kinase	kinase	NN	NN	_	26	compound	_	_
26	Akt/PKB	akt/pkb	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PtdIns	ptdins	NN	NN	_	5	compound	_	_
5	3-kinase	3-kinase	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	Ras	ras	NN	NN	_	8	compound	_	_
8	signaling	signaling	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	explored	explore	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	PtdIns	ptdins	NN	NN	_	12	compound	_	_
12	3-kinase	3-kinase	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	initiate	initiate	VB	VB	_	9	acl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Rac-1	rac-1	NN	NN	_	18	compound	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathways	pathway	NNS	NNS	_	14	dobj	_	_
19	important	important	JJ	JJ	_	18	amod	_	_
20	for	for	IN	IN	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Akt/PKB	akt/pkb	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	5	ccomp	_	_
10	by	by	IN	IN	_	13	case	_	_
11	Ras	ras	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Ras	ras	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	initiate	initiate	VB	VB	_	3	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	Rac-1	rac-1	NN	NN	_	11	compound	_	_
10	mediated	mediated	JJ	JJ	_	11	amod	_	_
11	pathway	pathway	NN	NN	_	7	dobj	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	regulates	regulate	VBZ	VBZ	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	function	function	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	AP-1	ap-1	NN	NN	_	19	compound	_	_
19	complexes	complex	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	PtdIns	ptdins	NN	NN	_	3	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	3	compound	_	_
3	signals	signal	NNS	NNS	_	6	nsubj	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	mimic	mimic	VB	VB	_	0	root	_	_
7	p21ras	p21ras	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	induce	induce	VB	VB	_	6	conj	_	_
10	the	the	DT	DT	_	13	det	_	_
11	Rac	rac	NN	NN	_	12	nmod:npmod	_	_
12	mediated	mediated	JJ	JJ	_	13	amod	_	_
13	responses	response	NNS	NNS	_	9	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	neither	neither	CC	CC	_	4	cc:preconj	_	_
4	TCR	tcr	NN	NN	_	11	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	Ras	ras	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	AP-1	ap-1	NN	NN	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	dependent	dependent	JJ	JJ	_	0	root	_	_
12	on	on	IN	IN	_	14	case	_	_
13	PtdIns	ptdins	NN	NN	_	14	compound	_	_
14	3-kinase	3-kinase	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	PKB	pkb	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	activated	activate	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	response	response	NN	NN	_	7	dep	_	_
6	to	to	TO	TO	_	7	case	_	_
7	triggering	triggering	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	antigen	antigen	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	7	nmod	_	_
14	;	;	:	:	_	3	punct	_	_
15	PtdIns	ptdins	NN	NN	_	17	compound	_	_
16	3-kinase	3-kinase	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	both	both	CC	CC	_	3	parataxis	_	_
20	required	require	VBN	VBN	_	19	dep	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	sufficient	sufficient	JJ	JJ	_	19	conj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	this	this	DT	DT	_	26	det	_	_
25	TCR	tcr	NN	NN	_	26	compound	_	_
26	response	response	NN	NN	_	19	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	p21ras	p21ras	NN	NN	_	5	compound	_	_
5	signals	signal	NNS	NNS	_	7	nsubj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	unable	unable	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	Akt/PKB	akt/pkb	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cell	cell	NN	NN	_	11	nmod	_	_
15	nor	nor	CC	CC	_	7	cc	_	_
16	is	be	VBZ	VBZ	_	19	auxpass	_	_
17	Ras	ras	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	19	nsubjpass	_	_
19	required	require	VBN	VBN	_	7	conj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	Akt/PKB	akt/pkb	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	response	response	NN	NN	_	27	dep	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	TCR	tcr	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	5	nsubj	_	_
4	thus	thus	RB	RB	_	5	advmod	_	_
5	highlight	highlight	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	PtdIns	ptdins	NN	NN	_	8	compound	_	_
8	3-kinase	3-kinase	NN	NN	_	16	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Akt/PKB	akt/pkb	NN	NN	_	8	conj	_	_
11	are	be	VBP	VBP	_	16	cop	_	_
12	not	not	RB	RB	_	16	neg	_	_
13	universal	universal	JJ	JJ	_	16	amod	_	_
14	Ras	ras	NN	NN	_	16	compound	_	_
15	effector	effector	NN	NN	_	16	compound	_	_
16	molecules	molecule	NNS	NNS	_	5	ccomp	_	_
17	.	.	.	.	_	5	punct	_	_

1	Ras	ras	NN	NN	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	initiate	initiate	VB	VB	_	0	root	_	_
4	Rac-1	rac-1	NN	NN	_	5	nmod:npmod	_	_
5	regulated	regulated	JJ	JJ	_	7	amod	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	pathways	pathway	NNS	NNS	_	3	dobj	_	_
8	in	in	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	dep	_	_
10	context	context	NN	NN	_	16	dep	_	_
11	of	of	IN	IN	_	16	case	_	_
12	T	t	NN	NN	_	16	compound	_	_
13	cell	cell	NN	NN	_	16	compound	_	_
14	antigen	antigen	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	function	function	NN	NN	_	3	nmod	_	_
17	independently	independently	RB	RB	_	3	advmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	PtdIns	ptdins	NN	NN	_	21	compound	_	_
20	3-kinase	3-kinase	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Signal	signal	NN	NN	_	3	compound	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	abnormalities	abnormality	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	advanced	advanced	JJ	JJ	_	12	amod	_	_
11	renal	renal	JJ	JJ	_	12	amod	_	_
12	carcinoma	carcinoma	NN	NN	_	8	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	clinical	clinical	JJ	JJ	_	15	amod	_	_
15	relevance	relevance	NN	NN	_	3	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	effects	effect	NNS	NNS	_	15	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	therapy	therapy	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Studies	study	NNS	NNS	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	abnormalities	abnormality	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	CD3/T-cell	cd3/t-cell	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TCR	tcr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	4	cc	_	_
14	pathways	pathway	NNS	NNS	_	4	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	animals	animal	NNS	NNS	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	patients	patient	NNS	NNS	_	22	conj	_	_
25	with	with	IN	IN	_	27	case	_	_
26	advanced	advanced	JJ	JJ	_	27	amod	_	_
27	malignancy	malignancy	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Diminished	diminish	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	29	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TCRzeta	tcrzeta	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p56(lck)	p56(lck)	NN	NN	_	4	conj	_	_
7	that	that	WDT	WDT	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	4	acl:relcl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	TCR	tcr	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	reduced	reduce	VBN	VBN	_	16	amod	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	localization	localization	NN	NN	_	2	conj	_	_
17	of	of	IN	IN	_	26	case	_	_
18	RelA	rela	NN	NN	_	26	compound	_	_
19	containing	contain	VBG	VBG	_	26	amod	_	_
20	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
21	factor	factor	NN	NN	_	26	compound	_	_
22	kappaB	kappab	NN	NN	_	26	compound	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	NFkappaB	nfkappab	NN	NN	_	26	compound	_	_
25	)	)	-RRB-	-RRB-	_	26	punct	_	_
26	complexes	complex	NNS	NNS	_	16	nmod	_	_
27	have	have	VBP	VBP	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	noted	note	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	defects	defect	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	described	describe	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	malignant	malignant	JJ	JJ	_	13	amod	_	_
13	melanoma	melanoma	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	renal	renal	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	carcinoma	carcinoma	NN	NN	_	13	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	RCC	rcc	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	13	punct	_	_
22	ovarian	ovarian	JJ	JJ	_	23	amod	_	_
23	cancer	cancer	NN	NN	_	13	conj	_	_
24	,	,	,	,	_	13	punct	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	colorectal	colorectal	JJ	JJ	_	27	amod	_	_
27	cancer	cancer	NN	NN	_	13	conj	_	_
28	.	.	.	.	_	5	punct	_	_

1	Preliminary	preliminary	JJ	JJ	_	2	amod	_	_
2	observations	observation	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	indicate	indicate	VBP	VBP	_	0	root	_	_
5	possible	possible	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	4	dobj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	clinical	clinical	JJ	JJ	_	9	amod	_	_
9	variables	variable	NNS	NNS	_	6	nmod	_	_
10	such	such	JJ	JJ	_	12	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	stage	stage	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	selected	select	VBN	VBN	_	15	amod	_	_
15	instances	instance	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	characterize	characterize	VB	VB	_	20	advcl	_	_
4	altered	altered	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	TCRzeta	tcrzeta	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	p56(lck)	p56(lck)	NN	NN	_	7	appos	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	impaired	impaired	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	5	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NFkappaB	nfkappab	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	20	punct	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	obtained	obtain	VBN	VBN	_	0	root	_	_
21	from	from	IN	IN	_	23	case	_	_
22	65	65	CD	CD	_	23	nummod	_	_
23	patients	patient	NNS	NNS	_	20	nmod	_	_
24	with	with	IN	IN	_	25	case	_	_
25	RCC	rcc	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	23	punct	_	_
27	the	the	DT	DT	_	28	det	_	_
28	majority	majority	NN	NN	_	32	nsubj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	whom	whom	WP	WP	_	28	nmod	_	_
31	were	be	VBD	VBD	_	32	aux	_	_
32	receiving	receive	VBG	VBG	_	23	acl:relcl	_	_
33	combination	combination	NN	NN	_	35	compound	_	_
34	cytokine	cytokine	NN	NN	_	35	compound	_	_
35	therapy	therapy	NN	NN	_	32	dobj	_	_
36	-LSB-	-lsb-	-LRB-	-LRB-	_	45	punct	_	_
37	interleukin	interleukin	NN	NN	_	44	nmod:npmod	_	_
38	(	(	-LRB-	-LRB-	_	44	punct	_	_
39	IL	il	NN	NN	_	44	nmod:npmod	_	_
40	)	)	-RRB-	-RRB-	_	44	punct	_	_
41	-2	-2	CD	CD	_	44	compound	_	_
42	,	,	,	,	_	44	punct	_	_
43	IFN	ifn	NN	NN	_	44	nmod:npmod	_	_
44	alpha-containing	alpha-containing	JJ	JJ	_	45	amod	_	_
45	regimens	regimen	NNS	NNS	_	35	appos	_	_
46	-RSB-	-rsb-	-RRB-	-RRB-	_	45	punct	_	_
47	and	and	CC	CC	_	23	cc	_	_
48	37	37	CD	CD	_	50	nummod	_	_
49	control	control	JJ	JJ	_	50	amod	_	_
50	individuals	individual	NNS	NNS	_	23	conj	_	_
51	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	29	29	CD	CD	_	13	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	13	punct	_	_
7	levels	level	NNS	NNS	_	13	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TCRzeta	tcrzeta	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p56(lck)	p56(lck)	NN	NN	_	9	conj	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	determined	determine	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	Western	western	NN	NN	_	16	compound	_	_
16	blots	blot	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	lysates	lysate	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	semiquantitated	semiquantitate	VBN	VBN	_	13	conj	_	_
22	using	use	VBG	VBG	_	21	xcomp	_	_
23	densitometry	densitometry	NN	NN	_	22	dobj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Relative	relative	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	then	then	RB	RB	_	5	advmod	_	_
5	correlated	correlate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	series	series	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	variables	variable	NNS	NNS	_	8	nmod	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	response	response	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	therapy	therapy	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	performance	performance	NN	NN	_	18	compound	_	_
18	status	status	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	13	punct	_	_
20	survival	survival	NN	NN	_	13	conj	_	_
21	,	,	,	,	_	13	punct	_	_
22	disease	disease	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	13	conj	_	_
24	,	,	,	,	_	13	punct	_	_
25	age	age	NN	NN	_	13	conj	_	_
26	,	,	,	,	_	13	punct	_	_
27	and	and	CC	CC	_	13	cc	_	_
28	others	other	NNS	NNS	_	13	conj	_	_
29	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	another	another	DT	DT	_	3	det	_	_
3	group	group	NN	NN	_	23	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	28	28	CD	CD	_	6	nummod	_	_
6	patients	patient	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	three	three	CD	CD	_	9	nummod	_	_
9	individuals	individual	NNS	NNS	_	6	dep	_	_
10	from	from	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	first	first	JJ	JJ	_	13	amod	_	_
13	group	group	NN	NN	_	9	nmod	_	_
14	)	)	-RRB-	-RRB-	_	9	punct	_	_
15	,	,	,	,	_	23	punct	_	_
16	the	the	DT	DT	_	17	det	_	_
17	frequency	frequency	NN	NN	_	23	nsubjpass	_	_
18	of	of	IN	IN	_	21	case	_	_
19	abnormal	abnormal	JJ	JJ	_	21	amod	_	_
20	NFkappaB	nfkappab	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	17	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	studied	study	VBN	VBN	_	0	root	_	_
24	using	use	VBG	VBG	_	23	xcomp	_	_
25	electrophoretic	electrophoretic	JJ	JJ	_	28	amod	_	_
26	mobility	mobility	NN	NN	_	28	compound	_	_
27	shift	shift	NN	NN	_	28	compound	_	_
28	assays	assay	NNS	NNS	_	24	dobj	_	_
29	after	after	IN	IN	_	30	case	_	_
30	activation	activation	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	with	with	IN	IN	_	37	case	_	_
35	phorbol	phorbol	NN	NN	_	37	compound	_	_
36	myristate	myristate	NN	NN	_	37	compound	_	_
37	acetate/ionomycin	acetate/ionomycin	NN	NN	_	30	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	anti-CD3	anti-cd3	JJ	JJ	_	41	amod	_	_
40	monoclonal	monoclonal	JJ	JJ	_	41	amod	_	_
41	antibody	antibody	NN	NN	_	37	conj	_	_
42	.	.	.	.	_	23	punct	_	_

1	Changes	change	NNS	NNS	_	11	nsubjpass	_	_
2	in	in	IN	IN	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	signaling	signal	VBG	VBG	_	5	amod	_	_
5	molecules	molecule	NNS	NNS	_	1	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	treatment	treatment	NN	NN	_	1	nmod	_	_
9	were	be	VBD	VBD	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	investigated	investigate	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	TCRzeta	tcrzeta	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	p56(lck)	p56(lck)	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	detected	detect	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	27	27	CD	CD	_	15	compound	_	_
14	of	of	IN	IN	_	15	advmod	_	_
15	29	29	CD	CD	_	16	nummod	_	_
16	patients	patient	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	overall	overall	RB	RB	_	24	advmod	_	_
20	,	,	,	,	_	24	punct	_	_
21	reduced	reduce	VBN	VBN	_	22	amod	_	_
22	levels	level	NNS	NNS	_	24	nsubjpass	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	noted	note	VBN	VBN	_	5	conj	_	_
25	visually	visually	RB	RB	_	24	advmod	_	_
26	in	in	IN	IN	_	42	case	_	_
27	12	12	CD	CD	_	29	compound	_	_
28	of	of	IN	IN	_	29	advmod	_	_
29	29	29	CD	CD	_	42	nummod	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	41	41	CD	CD	_	32	nummod	_	_
32	%	%	NN	NN	_	29	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	13	13	CD	CD	_	37	compound	_	_
36	of	of	IN	IN	_	37	advmod	_	_
37	29	29	CD	CD	_	29	conj	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	45	45	CD	CD	_	40	nummod	_	_
40	%	%	NN	NN	_	37	dep	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	individuals	individual	NNS	NNS	_	24	nmod	_	_
43	,	,	,	,	_	24	punct	_	_
44	respectively	respectively	RB	RB	_	24	advmod	_	_
45	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	levels	level	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	semiquantitated	semiquantitate	VBN	VBN	_	39	advcl	_	_
5	using	use	VBG	VBG	_	4	xcomp	_	_
6	densitometry	densitometry	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	39	punct	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	decreases	decrease	NNS	NNS	_	39	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TCRzeta	tcrzeta	NN	NN	_	9	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	P	p	NN	NN	_	14	nsubj	_	_
14	=	=	JJ	JJ	_	11	dep	_	_
15	0.029	0.029	CD	CD	_	14	dobj	_	_
16	)	)	-RRB-	-RRB-	_	14	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	p56(lck)	p56(lck)	NN	NN	_	11	conj	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	P	p	NN	NN	_	21	nsubj	_	_
21	=	=	JJ	JJ	_	18	dep	_	_
22	0.029	0.029	CD	CD	_	21	dobj	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	but	but	CC	CC	_	25	cc	_	_
25	not	not	RB	RB	_	11	cc	_	_
26	CD3epsilon	cd3epsilon	NN	NN	_	11	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	P	p	NN	NN	_	29	nsubj	_	_
29	=	=	JJ	JJ	_	26	dep	_	_
30	0.131	0.131	CD	CD	_	29	dobj	_	_
31	)	)	-RRB-	-RRB-	_	29	punct	_	_
32	,	,	,	,	_	39	punct	_	_
33	compared	compare	VBN	VBN	_	36	case	_	_
34	with	with	IN	IN	_	36	case	_	_
35	control	control	NN	NN	_	36	compound	_	_
36	levels	level	NNS	NNS	_	39	advcl	_	_
37	,	,	,	,	_	39	punct	_	_
38	were	be	VBD	VBD	_	39	auxpass	_	_
39	found	find	VBN	VBN	_	0	root	_	_
40	.	.	.	.	_	39	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	13	nmod	_	_
3	treated	treat	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	7	case	_	_
5	IL-2/IFN	il-2/ifn	NN	NN	_	6	nmod:npmod	_	_
6	alpha-based	alpha-based	JJ	JJ	_	7	amod	_	_
7	therapy	therapy	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	relative	relative	JJ	JJ	_	10	amod	_	_
10	levels	level	NNS	NNS	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	TCRzeta	tcrzeta	NN	NN	_	10	nmod	_	_
13	increased	increase	VBD	VBD	_	0	root	_	_
14	significantly	significantly	RB	RB	_	13	advmod	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	P	p	NN	NN	_	17	nsubj	_	_
17	=	=	JJ	JJ	_	13	parataxis	_	_
18	0.002	0.002	CD	CD	_	17	dobj	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	on	on	IN	IN	_	21	case	_	_
21	day	day	NN	NN	_	13	nmod	_	_
22	15	15	CD	CD	_	21	nummod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	cycle	cycle	NN	NN	_	21	nmod	_	_
25	one	one	CD	CD	_	24	nummod	_	_
26	compared	compare	VBN	VBN	_	29	case	_	_
27	with	with	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	baseline	baseline	NN	NN	_	13	advcl	_	_
30	.	.	.	.	_	13	punct	_	_

1	Correlations	correlation	NNS	NNS	_	32	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	TCRzeta	tcrzeta	NN	NN	_	6	compound	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	p56(lck)	p56(lck)	NN	NN	_	3	conj	_	_
6	levels	level	NNS	NNS	_	1	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	response	response	NN	NN	_	11	compound	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	disease	disease	NN	NN	_	8	conj	_	_
11	variables	variable	NNS	NNS	_	1	nmod	_	_
12	,	,	,	,	_	1	punct	_	_
13	except	except	IN	IN	_	17	case	_	_
14	for	for	IN	IN	_	17	case	_	_
15	lower	lower	JJR	JJR	_	17	amod	_	_
16	TCRzeta	tcrzeta	NN	NN	_	17	compound	_	_
17	levels	level	NNS	NNS	_	1	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	P	p	NN	NN	_	20	dep	_	_
20	&lt;	&lt;	JJR	JJR	_	17	dep	_	_
21	0.001	0.001	CD	CD	_	20	nummod	_	_
22	)	)	-RRB-	-RRB-	_	20	punct	_	_
23	in	in	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	dep	_	_
25	presence	presence	NN	NN	_	28	dep	_	_
26	of	of	IN	IN	_	28	case	_	_
27	bone	bone	NN	NN	_	28	compound	_	_
28	metastases	metastase	NNS	NNS	_	17	nmod	_	_
29	,	,	,	,	_	1	punct	_	_
30	were	be	VBD	VBD	_	32	auxpass	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	found	find	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	3	amod	_	_
2	NFkappaB	nfkappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	15	nsubjpass	_	_
4	after	after	IN	IN	_	5	case	_	_
5	stimulation	stimulation	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	phorbol	phorbol	NN	NN	_	9	compound	_	_
8	myristate	myristate	NN	NN	_	9	compound	_	_
9	acetate/ionomycin	acetate/ionomycin	NN	NN	_	5	nmod	_	_
10	and/or	and/or	CC	CC	_	9	cc	_	_
11	anti-CD3	anti-cd3	JJ	JJ	_	13	amod	_	_
12	monoclonal	monoclonal	JJ	JJ	_	13	amod	_	_
13	antibody	antibody	NN	NN	_	9	conj	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	59	59	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	18	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	17	17	CD	CD	_	24	compound	_	_
23	of	of	IN	IN	_	24	advmod	_	_
24	28	28	CD	CD	_	18	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	was	be	VBD	VBD	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	accounted	account	VBN	VBN	_	15	conj	_	_
30	for	for	IN	IN	_	29	nmod	_	_
31	by	by	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	advanced	advanced	JJ	JJ	_	34	amod	_	_
34	age	age	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	study	study	NN	NN	_	38	compound	_	_
38	cohort	cohort	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NFkappaB	nfkappab	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	8	case	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	inducible	inducible	JJ	JJ	_	0	root	_	_
11	during	during	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	therapy	therapy	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	four	four	CD	CD	_	17	compound	_	_
16	of	of	IN	IN	_	17	advmod	_	_
17	six	six	CD	CD	_	18	nummod	_	_
18	individuals	individual	NNS	NNS	_	13	nmod	_	_
19	who	who	WP	WP	_	20	nsubj	_	_
20	displayed	display	VBD	VBD	_	18	acl:relcl	_	_
21	impaired	impaired	JJ	JJ	_	23	amod	_	_
22	NFkappaB	nfkappab	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	prior	prior	RB	RB	_	26	case	_	_
25	to	to	TO	TO	_	24	mwe	_	_
26	therapy	therapy	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	impaired	impaired	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NFkappaB	nfkappab	NN	NN	_	4	nmod	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	appear	appear	VB	VB	_	0	root	_	_
10	linked	link	VBN	VBN	_	9	dep	_	_
11	to	to	TO	TO	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	reduction	reduction	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	TCRzeta	tcrzeta	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	because	because	IN	IN	_	27	mark	_	_
19	in	in	IN	IN	_	21	case	_	_
20	five	five	CD	CD	_	21	nummod	_	_
21	patients	patient	NNS	NNS	_	27	nmod	_	_
22	,	,	,	,	_	27	punct	_	_
23	normal	normal	JJ	JJ	_	25	amod	_	_
24	TCRzeta	tcrzeta	NN	NN	_	25	compound	_	_
25	levels	level	NNS	NNS	_	27	nsubj	_	_
26	were	be	VBD	VBD	_	27	cop	_	_
27	present	present	JJ	JJ	_	9	advcl	_	_
28	although	although	IN	IN	_	33	mark	_	_
29	kappaB	kappab	NN	NN	_	30	compound	_	_
30	binding	binding	NN	NN	_	33	nsubj	_	_
31	was	be	VBD	VBD	_	33	cop	_	_
32	not	not	RB	RB	_	33	neg	_	_
33	inducible	inducible	JJ	JJ	_	27	advcl	_	_
34	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	majority	majority	NN	NN	_	14	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	advanced	advanced	JJ	JJ	_	8	amod	_	_
8	RCC	rcc	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	14	punct	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	14	nsubj	_	_
14	express	express	VBP	VBP	_	0	root	_	_
15	TCRzeta	tcrzeta	NN	NN	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	p56(lck)	p56(lck)	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	subset	subset	NN	NN	_	32	nmod	_	_
23	,	,	,	,	_	32	punct	_	_
24	reduced	reduce	VBN	VBN	_	25	amod	_	_
25	levels	level	NNS	NNS	_	32	nsubjpass	_	_
26	of	of	IN	IN	_	30	case	_	_
27	these	these	DT	DT	_	30	det	_	_
28	TCRzeta	tcrzeta	NN	NN	_	30	compound	_	_
29	associated	associated	JJ	JJ	_	30	amod	_	_
30	molecules	molecule	NNS	NNS	_	25	nmod	_	_
31	are	be	VBP	VBP	_	32	auxpass	_	_
32	seen	see	VBN	VBN	_	14	conj	_	_
33	that	that	WDT	WDT	_	35	nsubj	_	_
34	may	may	MD	MD	_	35	aux	_	_
35	increase	increase	VB	VB	_	32	ccomp	_	_
36	during	during	IN	IN	_	38	case	_	_
37	cytokine-based	cytokine-based	JJ	JJ	_	38	amod	_	_
38	therapy	therapy	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NFkappaB	nfkappab	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	present	present	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	&gt;	&gt;	JJR	JJR	_	10	advmod	_	_
10	50	50	CD	CD	_	11	nummod	_	_
11	%	%	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	revert	revert	VB	VB	_	7	conj	_	_
18	to	to	TO	TO	_	19	case	_	_
19	normal	normal	JJ	JJ	_	17	nmod	_	_
20	during	during	IN	IN	_	23	case	_	_
21	IL-2/IFN	il-2/ifn	NN	NN	_	22	nmod:npmod	_	_
22	alpha-based	alpha-based	JJ	JJ	_	23	amod	_	_
23	treatment	treatment	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	alteration	alteration	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	NFkappaB	nfkappab	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	occurred	occur	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	dep	_	_
9	presence	presence	NN	NN	_	12	dep	_	_
10	of	of	IN	IN	_	12	case	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	TCRzeta-associated	tcrzeta-associated	JJ	JJ	_	16	amod	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	elements	element	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	clinical	clinical	JJ	JJ	_	3	amod	_	_
3	significance	significance	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	findings	finding	NNS	NNS	_	3	nmod	_	_
7	remains	remain	VBZ	VBZ	_	0	root	_	_
8	unclear	unclear	JJ	JJ	_	7	xcomp	_	_
9	.	.	.	.	_	7	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	lysosomal	lysosomal	JJ	JJ	_	6	amod	_	_
5	acid	acid	NN	NN	_	6	compound	_	_
6	lipase	lipase	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	differentiating	differentiate	VBG	VBG	_	2	acl	_	_
9	monocytes	monocyte	NNS	NNS	_	8	dobj	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	Sp1	sp1	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	AP-2	ap-2	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	lysosomal	lysosomal	JJ	JJ	_	4	amod	_	_
3	acid	acid	NN	NN	_	4	compound	_	_
4	lipase	lipase	NN	NN	_	10	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LAL	lal	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	a	a	DT	DT	_	10	det	_	_
10	hydrolase	hydrolase	NN	NN	_	0	root	_	_
11	required	require	VBN	VBN	_	10	acl	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	cleavage	cleavage	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cholesteryl	cholesteryl	NN	NN	_	17	compound	_	_
17	esters	ester	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	triglycerides	triglyceride	NNS	NNS	_	17	conj	_	_
20	derived	derive	VBN	VBN	_	17	acl	_	_
21	from	from	IN	IN	_	23	case	_	_
22	plasma	plasma	NN	NN	_	23	compound	_	_
23	lipoproteins	lipoprotein	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	during	during	IN	IN	_	10	case	_	_
7	monocyte	monocyte	NN	NN	_	10	compound	_	_
8	to	to	TO	TO	_	7	dep	_	_
9	macrophage	macrophage	NN	NN	_	7	dep	_	_
10	differentiation	differentiation	NN	NN	_	17	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	17	nsubjpass	_	_
14	of	of	IN	IN	_	15	case	_	_
15	LAL-mRNA	lal-mrna	NN	NN	_	13	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	3	ccomp	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	dependent	dependent	JJ	JJ	_	0	root	_	_
5	on	on	IN	IN	_	9	case	_	_
6	protein	protein	NN	NN	_	9	compound	_	_
7	kinase	kinase	NN	NN	_	9	compound	_	_
8	C	c	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	3	nmod:npmod	_	_
3	type-specific	type-specific	JJ	JJ	_	4	amod	_	_
4	increase	increase	NN	NN	_	10	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	LAL	lal	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	investigated	investigate	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	THP-1	thp-1	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	10	nmod	_	_
16	with	with	IN	IN	_	20	case	_	_
17	respect	respect	NN	NN	_	20	dep	_	_
18	to	to	TO	TO	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	human	human	JJ	JJ	_	7	amod	_	_
3	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
4	leukemia	leukemia	NN	NN	_	7	compound	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	line	line	NN	NN	_	7	compound	_	_
7	THP-1	thp-1	NN	NN	_	8	nsubj	_	_
8	differentiates	differentiate	VBZ	VBZ	_	0	root	_	_
9	into	into	IN	IN	_	11	case	_	_
10	macrophage-like	macrophage-like	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	when	when	WRB	WRB	_	13	advmod	_	_
13	treated	treat	VBN	VBN	_	8	advcl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	esters	ester	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	determine	determine	VB	VB	_	24	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cis-acting	cis-acting	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	4	dobj	_	_
8	necessary	necessary	JJ	JJ	_	7	amod	_	_
9	for	for	IN	IN	_	21	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	basal	basal	JJ	JJ	_	21	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	phorbol	phorbol	NN	NN	_	19	nmod:npmod	_	_
14	12-myristate-13	12-myristate-13	JJ	JJ	_	19	amod	_	_
15	acetate	acetate	NN	NN	_	19	nmod:npmod	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	PMA	pma	NN	NN	_	19	nmod:npmod	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	-enhanced	-enhanced	JJ	JJ	_	11	conj	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	8	nmod	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	performed	perform	VBD	VBD	_	0	root	_	_
25	deletion	deletion	NN	NN	_	26	compound	_	_
26	analysis	analysis	NN	NN	_	24	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	reporter	reporter	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	assays	assay	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	24	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	PMA	pma	NN	NN	_	4	compound	_	_
3	responsive	responsive	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	between	between	IN	IN	_	10	case	_	_
9	-182	-182	CD	CD	_	10	nummod	_	_
10	bp	bp	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	-107	-107	CD	CD	_	13	nummod	_	_
13	bp	bp	NN	NN	_	10	conj	_	_
14	upstream	upstream	RB	RB	_	10	advmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	major	major	JJ	JJ	_	20	amod	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	start	start	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	binding	binding	NN	NN	_	17	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Sp1	sp1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	AP-2	ap-2	NN	NN	_	9	conj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	LAL	lal	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	7	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	increased	increase	VBN	VBN	_	5	ccomp	_	_
18	by	by	IN	IN	_	19	case	_	_
19	PMA	pma	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	THP-1	thp-1	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Co-transfections	co-transfection	NNS	NNS	_	10	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	plasmids	plasmid	NNS	NNS	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	Sp1	sp1	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-2	ap-2	NN	NN	_	6	conj	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	emphasized	emphasize	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	these	these	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	24	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	basal	basal	JJ	JJ	_	24	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	PMA-enhanced	pma-enhanced	JJ	JJ	_	20	conj	_	_
23	LAL	lal	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	13	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	differentiation	differentiation	NN	NN	_	6	nmod:npmod	_	_
6	dependent	dependent	JJ	JJ	_	7	amod	_	_
7	increase	increase	NN	NN	_	20	nsubjpass	_	_
8	of	of	IN	IN	_	15	case	_	_
9	lysosomal	lysosomal	JJ	JJ	_	11	amod	_	_
10	acid	acid	NN	NN	_	11	compound	_	_
11	lipase	lipase	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	LAL	lal	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	expression	expression	NN	NN	_	7	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	THP-1	thp-1	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	7	nmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
21	by	by	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	concerted	concerted	JJ	JJ	_	24	amod	_	_
24	action	action	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Sp1	sp1	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	AP-2	ap-2	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	3	punct	_	_
2	Molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	cytokine	cytokine	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	Th1	th1	NN	NN	_	3	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Th2	th2	NN	NN	_	9	conj	_	_
12	-RSB-	-rsb-	-RRB-	-RRB-	_	3	punct	_	_

1	Upon	upon	IN	IN	_	2	case	_	_
2	activation	activation	NN	NN	_	9	nmod	_	_
3	by	by	IN	IN	_	4	case	_	_
4	antigens	antigen	NNS	NNS	_	2	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	helper	helper	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	differentiate	differentiate	VBP	VBP	_	0	root	_	_
10	into	into	IN	IN	_	11	case	_	_
11	one	one	CD	CD	_	9	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	several	several	JJ	JJ	_	14	amod	_	_
14	subsets	subset	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	characterized	characterize	VBN	VBN	_	14	acl	_	_
17	by	by	IN	IN	_	21	case	_	_
18	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
19	distinct	distinct	JJ	JJ	_	21	amod	_	_
20	cytokine-production	cytokine-production	NN	NN	_	21	amod	_	_
21	patterns	pattern	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	subsets	subset	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	Th1	th1	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	known	know	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	activate	activate	VB	VB	_	8	xcomp	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	immunity	immunity	NN	NN	_	10	dobj	_	_
13	resulting	result	VBG	VBG	_	12	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	whereas	whereas	IN	IN	_	8	dep	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	21	nsubj	_	_
21	induce	induce	VBP	VBP	_	8	parataxis	_	_
22	humoral	humoral	JJ	JJ	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	allergic	allergic	JJ	JJ	_	22	conj	_	_
25	responses	response	NNS	NNS	_	21	dobj	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	suppress	suppress	VBP	VBP	_	21	conj	_	_
28	inflammation	inflammation	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	8	punct	_	_

1	Th1	th1	NN	NN	_	5	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Th2	th2	NN	NN	_	1	conj	_	_
4	effector	effector	NN	NN	_	5	compound	_	_
5	functions	function	NNS	NNS	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
8	development	development	NN	NN	_	5	conj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	attributable	attributable	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	16	case	_	_
12	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
13	distinct	distinct	JJ	JJ	_	16	amod	_	_
14	cytokine	cytokine	NN	NN	_	16	compound	_	_
15	expression	expression	NN	NN	_	16	compound	_	_
16	patterns	pattern	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	22	mark	_	_
6	differential	differential	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	22	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	surface	surface	NN	NN	_	11	compound	_	_
11	molecules	molecule	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	such	such	JJ	JJ	_	16	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	adhesion	adhesion	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	chemokine	chemokine	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	11	punct	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	involved	involve	VBN	VBN	_	4	ccomp	_	_
23	in	in	IN	IN	_	25	case	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	recruitment	recruitment	NN	NN	_	22	nmod	_	_
26	into	into	IN	IN	_	28	case	_	_
27	target	target	NN	NN	_	28	compound	_	_
28	tissues	tissue	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	6	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	6	auxpass	_	_
3	,	,	,	,	_	6	punct	_	_
4	therefore	therefore	RB	RB	_	6	advmod	_	_
5	,	,	,	,	_	6	punct	_	_
6	suggested	suggest	VBN	VBN	_	0	root	_	_
7	that	that	IN	IN	_	19	mark	_	_
8	clarification	clarification	NN	NN	_	19	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	mechanisms	mechanism	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	differential	differential	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	Th1/Th2	th1/th2	NN	NN	_	11	nmod	_	_
18	should	should	MD	MD	_	19	aux	_	_
19	lead	lead	VB	VB	_	6	ccomp	_	_
20	to	to	TO	TO	_	22	case	_	_
21	rational	rational	JJ	JJ	_	22	amod	_	_
22	strategies	strategy	NNS	NNS	_	19	nmod	_	_
23	for	for	IN	IN	_	24	mark	_	_
24	manipulating	manipulate	VBG	VBG	_	22	acl	_	_
25	pathological	pathological	JJ	JJ	_	27	amod	_	_
26	immune	immune	JJ	JJ	_	27	amod	_	_
27	responses	response	NNS	NNS	_	24	dobj	_	_
28	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	helper	helper	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	mediated	mediate	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	6	nmod	_	_
12	induces	induce	VBZ	VBZ	_	0	root	_	_
13	a	a	DT	DT	_	14	det	_	_
14	series	series	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	biochemical	biochemical	JJ	JJ	_	17	amod	_	_
17	events	event	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Among	among	IN	IN	_	2	case	_	_
2	them	they	PRP	PRP	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	both	both	CC	CC	_	6	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	PKC/Ras-	pkc/ras-	NN	NN	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CaM/CN-mediated	cam/cn-mediated	JJ	JJ	_	8	conj	_	_
11	pathways	pathway	NNS	NNS	_	6	nmod	_	_
12	play	play	VBP	VBP	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	central	central	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	signal	signal	NN	NN	_	19	compound	_	_
19	transduction	transduction	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	cytokine	cytokine	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Closer	closer	JJR	JJR	_	2	amod	_	_
2	examination	examination	NN	NN	_	10	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	non-transformed	non-transformed	JJ	JJ	_	6	amod	_	_
5	murine	murine	JJ	JJ	_	6	amod	_	_
6	Th1	th1	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Th2	th2	NN	NN	_	9	compound	_	_
9	clones	clone	NNS	NNS	_	6	conj	_	_
10	suggested	suggest	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	22	mark	_	_
12	a	a	DT	DT	_	13	det	_	_
13	balance	balance	NN	NN	_	22	nsubj	_	_
14	between	between	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	activities	activity	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	two	two	CD	CD	_	21	nummod	_	_
20	signaling	signaling	NN	NN	_	21	compound	_	_
21	pathways	pathway	NNS	NNS	_	16	nmod	_	_
22	contributes	contribute	VBZ	VBZ	_	10	ccomp	_	_
23	to	to	TO	TO	_	26	case	_	_
24	cytokine	cytokine	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	one	one	CD	CD	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	targets	target	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PGE2	pge2	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	whose	whose	WP$	WP$	_	12	nmod:poss	_	_
12	effect	effect	NN	NN	_	13	nsubj	_	_
13	distinguishes	distinguish	VBZ	VBZ	_	9	acl:relcl	_	_
14	Th1	th1	NN	NN	_	13	dobj	_	_
15	from	from	IN	IN	_	16	case	_	_
16	Th2	th2	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	resides	reside	VBZ	VBZ	_	2	ccomp	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	downstream	downstream	JJ	JJ	_	23	amod	_	_
22	PKC/Ras-mediated	pkc/ras-mediated	JJ	JJ	_	23	amod	_	_
23	pathway	pathway	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	GATA-3	gata-3	NN	NN	_	2	nsubj	_	_
2	represses	repress	VBZ	VBZ	_	0	root	_	_
3	gp91phox	gp91phox	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	eosinophil-committed	eosinophil-committed	JJ	JJ	_	9	amod	_	_
8	HL-60-C15	hl-60-c15	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	15	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	gp91phox	gp91phox	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	eosinophils	eosinophil	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	transiently	transiently	RB	RB	_	15	advmod	_	_
15	transfected	transfect	VBD	VBD	_	0	root	_	_
16	eosinophil-committed	eosinophil-committed	JJ	JJ	_	18	amod	_	_
17	HL-60-C15	hl-60-c15	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	dobj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	gp91phox	gp91phox	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	constructs	construct	NNS	NNS	_	15	nmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	identified	identify	VBD	VBD	_	15	conj	_	_
26	a	a	DT	DT	_	28	det	_	_
27	negative	negative	JJ	JJ	_	28	amod	_	_
28	element	element	NN	NN	_	25	dobj	_	_
29	from	from	IN	IN	_	30	case	_	_
30	bp	bp	NN	NN	_	28	nmod	_	_
31	-267	-267	CD	CD	_	30	dep	_	_
32	to	to	TO	TO	_	31	dep	_	_
33	-246	-246	CD	CD	_	31	dep	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	gp91phox	gp91phox	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	30	nmod	_	_
38	,	,	,	,	_	37	punct	_	_
39	the	the	DT	DT	_	40	det	_	_
40	deletion	deletion	NN	NN	_	43	nsubj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	which	which	WDT	WDT	_	40	nmod	_	_
43	caused	cause	VBD	VBD	_	37	acl:relcl	_	_
44	an	a	DT	DT	_	47	det	_	_
45	83	83	CD	CD	_	46	compound	_	_
46	%	%	NN	NN	_	47	amod	_	_
47	increase	increase	NN	NN	_	43	dobj	_	_
48	in	in	IN	IN	_	50	case	_	_
49	promoter	promoter	NN	NN	_	50	compound	_	_
50	activity	activity	NN	NN	_	47	nmod	_	_
51	.	.	.	.	_	15	punct	_	_

1	Electrophoresis	electrophoresis	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	GATA-3	gata-3	NN	NN	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	5	ccomp	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	GATA	gata	NN	NN	_	12	compound	_	_
11	consensus	consensus	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	from	from	IN	IN	_	14	case	_	_
14	bp	bp	NN	NN	_	12	nmod	_	_
15	-256	-256	CD	CD	_	14	dep	_	_
16	to	to	TO	TO	_	15	dep	_	_
17	-250	-250	CD	CD	_	15	dep	_	_
18	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	81	81	CD	CD	_	3	compound	_	_
3	%	%	NN	NN	_	4	amod	_	_
4	increment	increment	NN	NN	_	9	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	obtained	obtain	VBN	VBN	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	a	a	DT	DT	_	12	det	_	_
12	mutation	mutation	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	introduced	introduce	VBN	VBN	_	9	advcl	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	GATA-3	gata-3	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	bp	bp	NN	NN	_	26	compound	_	_
23	-267	-267	CD	CD	_	26	nummod	_	_
24	to	to	TO	TO	_	26	dep	_	_
25	+12	+12	CD	CD	_	26	nummod	_	_
26	construct	construct	NN	NN	_	19	nmod	_	_
27	,	,	,	,	_	19	punct	_	_
28	which	which	WDT	WDT	_	30	nsubj	_	_
29	is	be	VBZ	VBZ	_	30	cop	_	_
30	comparable	comparable	JJ	JJ	_	19	acl:relcl	_	_
31	to	to	TO	TO	_	32	case	_	_
32	that	that	DT	DT	_	30	nmod	_	_
33	of	of	IN	IN	_	39	case	_	_
34	the	the	DT	DT	_	39	det	_	_
35	bp	bp	NN	NN	_	39	compound	_	_
36	-245	-245	CD	CD	_	39	nummod	_	_
37	to	to	TO	TO	_	39	dep	_	_
38	+12	+12	CD	CD	_	39	nummod	_	_
39	construct	construct	NN	NN	_	32	nmod	_	_
40	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	GATA-3	gata-3	NN	NN	_	13	nsubj	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	binding	bind	VBG	VBG	_	5	acl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	GATA	gata	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	nmod	_	_
12	negatively	negatively	RB	RB	_	13	advmod	_	_
13	regulates	regulate	VBZ	VBZ	_	3	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	expression	expression	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	gene	gene	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	HL-60-C15	hl-60-c15	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	nongenomic	nongenomic	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	0	root	_	_
4	for	for	IN	IN	_	6	case	_	_
5	progesterone-mediated	progesterone-mediated	JJ	JJ	_	6	amod	_	_
6	immunosuppression	immunosuppression	NN	NN	_	3	nmod	_	_
7	:	:	:	:	_	3	punct	_	_
8	inhibition	inhibition	NN	NN	_	3	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	K+	k+	NN	NN	_	11	compound	_	_
11	channels	channel	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	Ca2+	ca2+	NN	NN	_	14	compound	_	_
14	signaling	signaling	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	8	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	progesterone	progesterone	NN	NN	_	6	nsubj	_	_
6	causes	cause	VBZ	VBZ	_	2	acl:relcl	_	_
7	localized	localized	JJ	JJ	_	8	amod	_	_
8	suppression	suppression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	response	response	NN	NN	_	8	nmod	_	_
13	during	during	IN	IN	_	14	case	_	_
14	pregnancy	pregnancy	NN	NN	_	6	nmod	_	_
15	has	have	VBZ	VBZ	_	16	aux	_	_
16	remained	remain	VBN	VBN	_	0	root	_	_
17	elusive	elusive	JJ	JJ	_	16	xcomp	_	_
18	.	.	.	.	_	16	punct	_	_

1	Using	use	VBG	VBG	_	11	advcl	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	4	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	show	show	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	25	mark	_	_
13	progesterone	progesterone	NN	NN	_	25	nsubj	_	_
14	,	,	,	,	_	25	punct	_	_
15	at	at	IN	IN	_	16	case	_	_
16	concentrations	concentration	NNS	NNS	_	25	nmod	_	_
17	found	find	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	placenta	placenta	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	25	punct	_	_
22	rapidly	rapidly	RB	RB	_	23	advmod	_	_
23	and	and	CC	CC	_	25	advmod	_	_
24	reversibly	reversibly	RB	RB	_	23	advmod	_	_
25	blocks	block	VBZ	VBZ	_	11	ccomp	_	_
26	voltage-gated	voltage-gated	JJ	JJ	_	30	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	calcium-activated	calcium-activated	JJ	JJ	_	26	conj	_	_
29	K+	k+	NN	NN	_	30	compound	_	_
30	channels	channel	NNS	NNS	_	25	dobj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	KV	kv	NN	NN	_	30	dep	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	KCa	kca	NN	NN	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	respectively	respectively	RB	RB	_	32	advmod	_	_
37	)	)	-RRB-	-RRB-	_	32	punct	_	_
38	,	,	,	,	_	25	punct	_	_
39	resulting	result	VBG	VBG	_	25	advcl	_	_
40	in	in	IN	IN	_	41	case	_	_
41	depolarization	depolarization	NN	NN	_	39	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	membrane	membrane	NN	NN	_	45	compound	_	_
45	potential	potential	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	11	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	result	result	NN	NN	_	21	nmod	_	_
4	,	,	,	,	_	21	punct	_	_
5	Ca2+	ca2+	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	21	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
9	factor	factor	NN	NN	_	13	compound	_	_
10	of	of	IN	IN	_	13	amod	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	17	nmod:npmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NF-AT	nf-at	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-driven	-driven	JJ	JJ	_	19	amod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	6	conj	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	inhibited	inhibit	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	Progesterone	progesterone	NN	NN	_	2	nsubj	_	_
2	acts	act	VBZ	VBZ	_	0	root	_	_
3	distally	distally	RB	RB	_	2	advmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	initial	initial	JJ	JJ	_	7	amod	_	_
7	steps	step	NNS	NNS	_	2	nmod	_	_
8	of	of	IN	IN	_	17	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	15	nmod:npmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TCR	tcr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	-mediated	-mediated	JJ	JJ	_	17	amod	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transduction	transduction	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	since	since	IN	IN	_	21	mark	_	_
20	it	it	PRP	PRP	_	21	nsubj	_	_
21	blocks	block	VBZ	VBZ	_	2	advcl	_	_
22	sustained	sustained	JJ	JJ	_	24	amod	_	_
23	Ca2+	ca2+	NN	NN	_	24	compound	_	_
24	signals	signal	NNS	NNS	_	21	dobj	_	_
25	after	after	IN	IN	_	27	case	_	_
26	thapsigargin	thapsigargin	NN	NN	_	27	compound	_	_
27	stimulation	stimulation	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	as	as	RB	RB	_	24	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	oscillatory	oscillatory	JJ	JJ	_	34	amod	_	_
33	Ca2+	ca2+	NN	NN	_	34	compound	_	_
34	signals	signal	NNS	NNS	_	24	conj	_	_
35	,	,	,	,	_	24	punct	_	_
36	but	but	CC	CC	_	37	cc	_	_
37	not	not	RB	RB	_	24	cc	_	_
38	the	the	DT	DT	_	39	det	_	_
39	Ca2+	ca2+	NN	NN	_	24	conj	_	_
40	transient	transient	JJ	JJ	_	39	amod	_	_
41	after	after	IN	IN	_	43	case	_	_
42	TCR	tcr	NN	NN	_	43	compound	_	_
43	stimulation	stimulation	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	2	punct	_	_

1	K+	k+	NN	NN	_	3	compound	_	_
2	channel	channel	NN	NN	_	3	compound	_	_
3	blockade	blockade	NN	NN	_	7	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	progesterone	progesterone	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	specific	specific	JJ	JJ	_	0	root	_	_
8	;	;	:	:	_	7	punct	_	_
9	other	other	JJ	JJ	_	11	amod	_	_
10	steroid	steroid	NN	NN	_	11	compound	_	_
11	hormones	hormone	NNS	NNS	_	12	nsubj	_	_
12	had	have	VBD	VBD	_	7	parataxis	_	_
13	little	little	JJ	JJ	_	12	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	no	no	DT	DT	_	13	conj	_	_
16	effect	effect	NN	NN	_	13	dep	_	_
17	,	,	,	,	_	12	punct	_	_
18	although	although	IN	IN	_	25	mark	_	_
19	the	the	DT	DT	_	22	det	_	_
20	progesterone	progesterone	NN	NN	_	22	compound	_	_
21	antagonist	antagonist	NN	NN	_	22	compound	_	_
22	RU	ru	NN	NN	_	25	nsubj	_	_
23	486	486	CD	CD	_	22	nummod	_	_
24	also	also	RB	RB	_	25	advmod	_	_
25	blocked	block	VBD	VBD	_	12	advcl	_	_
26	KV	kv	NN	NN	_	29	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	KCa	kca	NN	NN	_	26	conj	_	_
29	channels	channel	NNS	NNS	_	25	dobj	_	_
30	.	.	.	.	_	7	punct	_	_

1	Progesterone	progesterone	NN	NN	_	3	nsubj	_	_
2	effectively	effectively	RB	RB	_	3	advmod	_	_
3	blocked	block	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	broad	broad	JJ	JJ	_	6	amod	_	_
6	spectrum	spectrum	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	K+	k+	NN	NN	_	9	compound	_	_
9	channels	channel	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	reducing	reduce	VBG	VBG	_	3	dep	_	_
12	both	both	CC	CC	_	16	dep	_	_
13	Kv1.3	kv1.3	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	charybdotoxin-resistant	charybdotoxin-resistant	JJ	JJ	_	12	conj	_	_
16	components	component	NNS	NNS	_	11	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	KV	kv	NN	NN	_	19	compound	_	_
19	current	current	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	KCa	kca	NN	NN	_	22	compound	_	_
22	current	current	NN	NN	_	19	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	,	,	,	,	_	11	punct	_	_
27	as	as	RB	RB	_	11	cc	_	_
28	well	well	RB	RB	_	27	mwe	_	_
29	as	as	IN	IN	_	27	mwe	_	_
30	blocking	block	VBG	VBG	_	11	conj	_	_
31	several	several	JJ	JJ	_	34	amod	_	_
32	cloned	clone	VBN	VBN	_	34	amod	_	_
33	KV	kv	NN	NN	_	34	compound	_	_
34	channels	channel	NNS	NNS	_	30	dobj	_	_
35	expressed	express	VBN	VBN	_	34	acl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Progesterone	progesterone	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	little	little	JJ	JJ	_	2	dobj	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	no	no	DT	DT	_	3	conj	_	_
6	effect	effect	NN	NN	_	3	dep	_	_
7	on	on	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	cloned	clone	VBN	VBN	_	12	amod	_	_
10	voltage-gated	voltage-gated	JJ	JJ	_	12	amod	_	_
11	Na+	na+	NN	NN	_	12	compound	_	_
12	channel	channel	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	an	a	DT	DT	_	18	det	_	_
15	inward	inward	JJ	JJ	_	18	amod	_	_
16	rectifier	rectifier	NN	NN	_	18	compound	_	_
17	K+	k+	NN	NN	_	18	compound	_	_
18	channel	channel	NN	NN	_	12	appos	_	_
19	,	,	,	,	_	12	punct	_	_
20	or	or	CC	CC	_	12	cc	_	_
21	on	on	IN	IN	_	26	case	_	_
22	lymphocyte	lymphocyte	NN	NN	_	26	compound	_	_
23	Ca2+	ca2+	NN	NN	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Cl-	cl-	NN	NN	_	23	conj	_	_
26	channels	channel	NNS	NNS	_	12	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	inhibition	inhibition	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	K+	k+	NN	NN	_	8	compound	_	_
8	channels	channel	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	progesterone	progesterone	NN	NN	_	5	nmod	_	_
14	contributes	contribute	VBZ	VBZ	_	2	ccomp	_	_
15	to	to	TO	TO	_	17	case	_	_
16	progesterone-induced	progesterone-induced	JJ	JJ	_	17	amod	_	_
17	immunosuppression	immunosuppression	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IKK1	ikk1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IKK2	ikk2	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	lipopolysaccharide	lipopolysaccharide	NN	NN	_	8	compound	_	_
8	signaling	signaling	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Mononuclear	mononuclear	JJ	JJ	_	2	amod	_	_
2	phagocytes	phagocyte	NNS	NNS	_	3	nsubj	_	_
3	play	play	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	major	major	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	immune	immune	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	inflammatory	inflammatory	JJ	JJ	_	8	conj	_	_
11	responses	response	NNS	NNS	_	3	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	LPS	lps	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	monocytes	monocyte	NNS	NNS	_	6	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	express	express	VB	VB	_	6	xcomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	genes	gene	NNS	NNS	_	11	nmod	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	activating	activate	VBG	VBG	_	6	advcl	_	_
16	the	the	DT	DT	_	20	det	_	_
17	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	20	compound	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	15	dobj	_	_
21	.	.	.	.	_	6	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	reported	report	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	tumor	tumor	NN	NN	_	10	compound	_	_
9	necrosis	necrosis	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	16	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	interleukin	interleukin	NN	NN	_	15	compound	_	_
13	1	1	CD	CD	_	15	nummod	_	_
14	signaling	signaling	NN	NN	_	15	compound	_	_
15	pathways	pathway	NNS	NNS	_	10	conj	_	_
16	activate	activate	VBP	VBP	_	5	ccomp	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	kinases	kinase	NNS	NNS	_	16	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	IKK1	ikk1	NN	NN	_	18	appos	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	IKK2	ikk2	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	IkappaB	ikappab	NN	NN	_	6	compound	_	_
5	cytoplasmic	cytoplasmic	JJ	JJ	_	6	amod	_	_
6	inhibitors	inhibitor	NNS	NNS	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	IkappaBalpha	ikappabalpha	NN	NN	_	6	appos	_	_
9	,	,	,	,	_	8	punct	_	_
10	IkappaBbeta	ikappabbeta	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	IkappaBepsilon	ikappabepsilon	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	by	by	IN	IN	_	17	case	_	_
16	these	these	DT	DT	_	17	det	_	_
17	kinases	kinase	NNS	NNS	_	1	nmod	_	_
18	triggers	trigger	VBZ	VBZ	_	0	root	_	_
19	proteolytic	proteolytic	JJ	JJ	_	20	amod	_	_
20	degradation	degradation	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	23	det	_	_
23	release	release	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	23	nmod	_	_
27	into	into	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	nucleus	nucleus	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	present	present	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	IKKs	ikk	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	LPS	lps	NN	NN	_	11	compound	_	_
11	signaling	signaling	NN	NN	_	5	nmod	_	_
12	has	have	VBZ	VBZ	_	15	aux	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	investigated	investigate	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	LPS	lps	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
8	IKK	ikk	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	THP-1	thp-1	NN	NN	_	16	compound	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	kinetics	kinetics	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	kinase	kinase	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	relatively	relatively	RB	RB	_	13	advmod	_	_
13	slow	slow	JJ	JJ	_	0	root	_	_
14	with	with	IN	IN	_	17	mark	_	_
15	maximal	maximal	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	17	nsubj	_	_
17	observed	observe	VBN	VBN	_	13	advcl	_	_
18	at	at	IN	IN	_	20	case	_	_
19	60	60	CD	CD	_	20	nummod	_	_
20	min	min	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	coincides	coincide	VBZ	VBZ	_	17	ccomp	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	degradation	degradation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IkappaBs	ikappab	NNS	NNS	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	the	the	DT	DT	_	32	det	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	translocation	translocation	NN	NN	_	26	conj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	NF-kappaB	nf-kappab	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	26	nmod	_	_
4	,	,	,	,	_	26	punct	_	_
5	overexpression	overexpression	NN	NN	_	26	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	wild	wild	JJ	JJ	_	9	amod	_	_
8	type	type	NN	NN	_	9	compound	_	_
9	IKK1	ikk1	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	15	det	_	_
12	dominant	dominant	JJ	JJ	_	15	amod	_	_
13	negative	negative	JJ	JJ	_	15	amod	_	_
14	mutant	mutant	JJ	JJ	_	15	amod	_	_
15	IKK1	ikk1	NN	NN	_	9	appos	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	K44M	k44m	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	9	punct	_	_
20	or	or	CC	CC	_	9	cc	_	_
21	wild	wild	JJ	JJ	_	23	amod	_	_
22	type	type	NN	NN	_	23	compound	_	_
23	IKK2	ikk2	NN	NN	_	9	conj	_	_
24	did	do	VBD	VBD	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	affect	affect	VB	VB	_	0	root	_	_
27	LPS-induced	lps-induced	JJ	JJ	_	29	amod	_	_
28	kappaB-dependent	kappab-dependent	JJ	JJ	_	29	amod	_	_
29	transcription	transcription	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	monocytic	monocytic	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	26	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	dominant	dominant	JJ	JJ	_	7	amod	_	_
6	negative	negative	JJ	JJ	_	7	amod	_	_
7	mutant	mutant	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IKK2	ikk2	NN	NN	_	7	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	LPS	lps	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	kappaB-dependent	kappab-dependent	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	manner	manner	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	LPS	lps	NN	NN	_	6	compound	_	_
6	induction	induction	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	kappaB-dependent	kappab-dependent	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	requires	require	VBZ	VBZ	_	3	ccomp	_	_
16	activation	activation	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IKK2	ikk2	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	overexpression	overexpression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	IL-1	il-1	NN	NN	_	7	compound	_	_
6	receptor-associated	receptor-associated	JJ	JJ	_	7	amod	_	_
7	kinase	kinase	NN	NN	_	3	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	NFkappaB	nfkappab	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	conj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	stress-activated	stress-activated	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	kinases	kinase	NNS	NNS	_	10	conj	_	_
18	in	in	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	murine	murine	JJ	JJ	_	24	amod	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	line	line	NN	NN	_	24	compound	_	_
24	EL4	el4	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	association	association	NN	NN	_	20	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activation	activation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	IL-1	il-1	NN	NN	_	10	compound	_	_
8	receptor-associated	receptor-associated	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IRAK	irak	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	IL-1	il-1	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	2	nmod	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	one	one	CD	CD	_	0	root	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	earliest	earliest	JJS	JJS	_	24	amod	_	_
24	events	event	NNS	NNS	_	20	nmod	_	_
25	detectable	detectable	JJ	JJ	_	24	amod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	IL-1	il-1	NN	NN	_	29	compound	_	_
28	signal	signal	NN	NN	_	29	compound	_	_
29	transduction	transduction	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	generated	generate	VBD	VBD	_	0	root	_	_
3	permanent	permanent	JJ	JJ	_	4	amod	_	_
4	clones	clone	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	murine	murine	JJ	JJ	_	11	amod	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	line	line	NN	NN	_	11	compound	_	_
11	EL4	el4	NN	NN	_	4	nmod	_	_
12	6.1	6.1	CD	CD	_	11	nummod	_	_
13	overexpressing	overexpress	VBG	VBG	_	11	acl	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	h	h	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	IRAK	irak	NN	NN	_	13	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	evaluate	evaluate	VB	VB	_	2	advcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	role	role	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	kinase	kinase	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	IL-1	il-1	NN	NN	_	28	compound	_	_
28	signaling	signaling	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	hIRAK	hirak	NN	NN	_	1	nmod	_	_
4	enhanced	enhance	VBD	VBD	_	0	root	_	_
5	IL-1-stimulated	il-1-stimulated	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	NFkappaB	nfkappab	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	whereas	whereas	IN	IN	_	4	dep	_	_
14	a	a	DT	DT	_	16	det	_	_
15	truncated	truncate	VBN	VBN	_	16	amod	_	_
16	form	form	NN	NN	_	21	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	N-IRAK	n-irak	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	specifically	specifically	RB	RB	_	21	advmod	_	_
21	inhibited	inhibit	VBD	VBD	_	4	parataxis	_	_
22	IL-1-dependent	il-1-dependent	JJ	JJ	_	24	amod	_	_
23	NFkappaB	nfkappab	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	clones	clone	NNS	NNS	_	9	dep	_	_
3	stably	stably	RB	RB	_	4	advmod	_	_
4	overexpressing	overexpress	VBG	VBG	_	2	acl	_	_
5	hIRAK	hirak	NN	NN	_	4	dobj	_	_
6	a	a	DT	DT	_	9	det	_	_
7	weak	weak	JJ	JJ	_	9	amod	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NFkappaB	nfkappab	NN	NN	_	9	nmod	_	_
12	correlated	correlate	VBD	VBD	_	18	dep	_	_
13	with	with	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	low	low	JJ	JJ	_	18	amod	_	_
16	basal	basal	JJ	JJ	_	18	amod	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	production	production	NN	NN	_	9	advcl	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	enhanced	enhance	VBN	VBN	_	18	acl:relcl	_	_
22	in	in	IN	IN	_	25	case	_	_
23	an	a	DT	DT	_	25	det	_	_
24	IL-1-dependent	il-1-dependent	JJ	JJ	_	25	amod	_	_
25	manner	manner	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Compared	compare	VBN	VBN	_	6	case	_	_
2	to	to	TO	TO	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	parental	parental	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	15	advcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	dose-response	dose-response	JJ	JJ	_	9	amod	_	_
9	curve	curve	NN	NN	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	13	case	_	_
11	IL-1-induced	il-1-induced	JJ	JJ	_	13	amod	_	_
12	IL-2	il-2	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	9	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	shifted	shift	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	potency	potency	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	efficacy	efficacy	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IRAK	irak	NN	NN	_	7	nsubj	_	_
6	directly	directly	RB	RB	_	7	advmod	_	_
7	triggers	trigger	VBZ	VBZ	_	3	ccomp	_	_
8	NFkappaB-mediated	nfkappab-mediated	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	EL4	el4	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Qualitatively	qualitatively	RB	RB	_	5	advmod	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-1-induced	il-1-induced	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	16	case	_	_
11	stress-activated	stress-activated	JJ	JJ	_	16	amod	_	_
12	protein	protein	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	SAP	sap	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	kinases	kinase	NNS	NNS	_	9	nmod	_	_
17	:	:	:	:	_	5	punct	_	_
18	permanent	permanent	JJ	JJ	_	19	amod	_	_
19	overexpression	overexpression	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IRAK	irak	NN	NN	_	19	nmod	_	_
22	did	do	VBD	VBD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	affect	affect	VB	VB	_	5	parataxis	_	_
25	the	the	DT	DT	_	27	det	_	_
26	dose	dose	NN	NN	_	27	compound	_	_
27	dependence	dependence	NN	NN	_	24	dobj	_	_
28	but	but	CC	CC	_	24	cc	_	_
29	prolonged	prolong	VBD	VBD	_	24	conj	_	_
30	the	the	DT	DT	_	31	det	_	_
31	kinetics	kinetics	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	IL-1-induced	il-1-induced	JJ	JJ	_	34	amod	_	_
34	activation	activation	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	SAP	sap	NN	NN	_	37	compound	_	_
37	kinases	kinase	NNS	NNS	_	34	nmod	_	_
38	,	,	,	,	_	24	punct	_	_
39	suggesting	suggest	VBG	VBG	_	24	advcl	_	_
40	that	that	IN	IN	_	46	mark	_	_
41	this	this	DT	DT	_	43	det	_	_
42	signaling	signal	VBG	VBG	_	43	amod	_	_
43	branch	branch	NN	NN	_	46	nsubjpass	_	_
44	may	may	MD	MD	_	46	aux	_	_
45	be	be	VB	VB	_	46	auxpass	_	_
46	regulated	regulate	VBN	VBN	_	39	ccomp	_	_
47	by	by	IN	IN	_	49	case	_	_
48	distinct	distinct	JJ	JJ	_	49	amod	_	_
49	mechanisms	mechanism	NNS	NNS	_	46	nmod	_	_
50	.	.	.	.	_	5	punct	_	_

1	Decreased	decrease	VBN	VBN	_	3	amod	_	_
2	IL-12	il-12	NN	NN	_	3	compound	_	_
3	production	production	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Th1	th1	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	development	development	NN	NN	_	3	conj	_	_
8	by	by	IN	IN	_	12	case	_	_
9	acetyl	acetyl	NN	NN	_	11	nmod:npmod	_	_
10	salicylic	salicylic	JJ	JJ	_	11	amod	_	_
11	acid-mediated	acid-mediated	JJ	JJ	_	12	amod	_	_
12	inhibition	inhibition	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	IL-12	il-12	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	75-kDa	75-kda	JJ	JJ	_	6	amod	_	_
5	heterodimeric	heterodimeric	JJ	JJ	_	6	amod	_	_
6	cytokine	cytokine	NN	NN	_	0	root	_	_
7	composed	compose	VBN	VBN	_	6	acl	_	_
8	of	of	IN	IN	_	12	case	_	_
9	two	two	CD	CD	_	12	nummod	_	_
10	covalently	covalently	RB	RB	_	11	advmod	_	_
11	linked	link	VBN	VBN	_	12	amod	_	_
12	p35	p35	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	p40	p40	NN	NN	_	15	compound	_	_
15	chains	chain	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	pro-inflammatory	pro-inflammatory	JJ	JJ	_	3	amod	_	_
3	cytokine	cytokine	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	prominent	prominent	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	development	development	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	Th1	th1	NN	NN	_	13	nmod:npmod	_	_
13	cell-mediated	cell-mediated	JJ	JJ	_	15	amod	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	responses	response	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Th1	th1	NN	NN	_	2	nmod:npmod	_	_
2	cell-mediated	cell-mediated	JJ	JJ	_	4	amod	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	responses	response	NNS	NNS	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	implicated	implicate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	pathogenesis	pathogenesis	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	chronic	chronic	JJ	JJ	_	15	amod	_	_
13	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
14	autoimmune	autoimmune	JJ	JJ	_	15	amod	_	_
15	diseases	disease	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-12	il-12	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	9	mark	_	_
6	be	be	VB	VB	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	critical	critical	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	4	xcomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	generation	generation	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	maintenance	maintenance	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	chronic	chronic	JJ	JJ	_	18	amod	_	_
17	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
18	conditions	condition	NNS	NNS	_	12	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	commonly	commonly	RB	RB	_	12	advmod	_	_
12	prescribed	prescribe	VBN	VBN	_	14	amod	_	_
13	anti-inflammatory	anti-inflammatory	JJ	JJ	_	14	amod	_	_
14	drug	drug	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	acetyl	acetyl	NN	NN	_	18	compound	_	_
17	salicylic	salicylic	JJ	JJ	_	18	amod	_	_
18	acid	acid	NN	NN	_	14	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	ASA	asa	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	14	punct	_	_
23	on	on	IN	IN	_	25	case	_	_
24	IL-12	il-12	NN	NN	_	25	compound	_	_
25	production	production	NN	NN	_	8	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	Th1	th1	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	development	development	NN	NN	_	25	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	ASA	asa	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	inhibit	inhibit	VB	VB	_	3	xcomp	_	_
6	secretion	secretion	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IL-12	il-12	NN	NN	_	10	compound	_	_
10	heterodimer	heterodimer	NN	NN	_	6	nmod	_	_
11	as	as	RB	RB	_	10	cc	_	_
12	well	well	RB	RB	_	11	mwe	_	_
13	as	as	IN	IN	_	11	mwe	_	_
14	p40	p40	NN	NN	_	15	compound	_	_
15	monomer	monomer	NN	NN	_	10	conj	_	_
16	by	by	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	6	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	associated	associate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	down-regulation	down-regulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	IL-12p40	il-12p40	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	p40	p40	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	4	nmod	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	13	mark	_	_
12	ASA	asa	NN	NN	_	13	nsubj	_	_
13	inhibited	inhibit	VBD	VBD	_	10	ccomp	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	13	dobj	_	_
15	activation	activation	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	binding	binding	NN	NN	_	15	conj	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	p40-kappaB	p40-kappab	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	p40	p40	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	13	punct	_	_
27	leading	lead	VBG	VBG	_	13	advcl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	repression	repression	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	p40	p40	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	Addition	addition	NN	NN	_	25	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ASA	asa	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	12	case	_	_
5	an	a	DT	DT	_	12	det	_	_
6	in	in	FW	FW	_	12	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	T	t	NN	NN	_	12	compound	_	_
9	helper	helper	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	system	system	NN	NN	_	1	nmod	_	_
13	,	,	,	,	_	25	punct	_	_
14	at	at	IN	IN	_	15	case	_	_
15	concentrations	concentration	NNS	NNS	_	25	nmod	_	_
16	compatible	compatible	JJ	JJ	_	15	amod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	plasma	plasma	NN	NN	_	19	compound	_	_
19	levels	level	NNS	NNS	_	16	nmod	_	_
20	reached	reach	VBN	VBN	_	19	acl	_	_
21	during	during	IN	IN	_	23	case	_	_
22	anti-inflammatory	anti-inflammatory	JJ	JJ	_	23	amod	_	_
23	therapy	therapy	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	25	punct	_	_
25	resulted	result	VBD	VBD	_	0	root	_	_
26	in	in	IN	IN	_	28	case	_	_
27	reduced	reduce	VBN	VBN	_	28	amod	_	_
28	development	development	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	Th1	th1	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ASA	asa	NN	NN	_	6	nmod	_	_
12	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
13	to	to	TO	TO	_	14	case	_	_
14	down-regulation	down-regulation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IL-12	il-12	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	inhibition	inhibition	NN	NN	_	14	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	Th1	th1	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	development	development	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	YM268	ym268	NN	NN	_	2	nsubj	_	_
2	increases	increase	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	glucose	glucose	NN	NN	_	5	compound	_	_
5	uptake	uptake	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	5	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	glucose	glucose	NN	NN	_	15	compound	_	_
15	transporter	transporter	NN	NN	_	5	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	3T3-L1	3t3-l1	NN	NN	_	18	compound	_	_
18	adipocytes	adipocyte	NNS	NNS	_	5	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	examine	examine	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	bis-LSB-4--LSB-2,4-dioxo-5-thiazolidinyl)methyl-RSB-phenyl-RSB-	bis-lsb-4--lsb-2,4-dioxo-5-thiazolidinyl)methyl-rsb-phenyl-rsb-	NN	NN	_	13	compound	_	_
13	methane	methane	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	YM-268	ym-268	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	13	punct	_	_
18	a	a	DT	DT	_	20	det	_	_
19	thiazolidinedione	thiazolidinedione	JJ	JJ	_	20	amod	_	_
20	derivative	derivative	NN	NN	_	13	appos	_	_
21	,	,	,	,	_	13	punct	_	_
22	on	on	IN	IN	_	24	case	_	_
23	glucose	glucose	NN	NN	_	24	compound	_	_
24	uptake	uptake	NN	NN	_	10	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	adipocyte	adipocyte	NN	NN	_	27	compound	_	_
27	differentiation	differentiation	NN	NN	_	24	conj	_	_
28	through	through	IN	IN	_	32	case	_	_
29	peroxisome	peroxisome	NN	NN	_	32	compound	_	_
30	proliferator-activated	proliferator-activated	JJ	JJ	_	32	amod	_	_
31	receptor	receptor	NN	NN	_	32	compound	_	_
32	gamma	gamma	NN	NN	_	27	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PPARgamma	ppargamma	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	,	,	,	,	_	24	punct	_	_
37	and	and	CC	CC	_	24	cc	_	_
38	phosphatidylinositol	phosphatidylinositol	NN	NN	_	39	compound	_	_
39	3-kinase	3-kinase	NN	NN	_	44	compound	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	PI	pi	NN	NN	_	42	compound	_	_
42	3-kinase	3-kinase	NN	NN	_	39	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	activity	activity	NN	NN	_	24	conj	_	_
45	in	in	IN	IN	_	47	case	_	_
46	cultured	culture	VBN	VBN	_	47	amod	_	_
47	cells	cell	NNS	NNS	_	44	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	YM268	ym268	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	pioglitazone	pioglitazone	NN	NN	_	1	conj	_	_
4	dose-dependently	dose-dependently	RB	RB	_	5	advmod	_	_
5	increased	increase	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	2-deoxyglucose	2-deoxyglucose	NN	NN	_	8	compound	_	_
8	uptake	uptake	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	3T3-L1	3t3-l1	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	YM268	ym268	NN	NN	_	2	nsubj	_	_
2	facilitated	facilitate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	insulin-stimulated	insulin-stimulated	JJ	JJ	_	6	amod	_	_
5	triglyceride	triglyceride	NN	NN	_	6	compound	_	_
6	accumulation	accumulation	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	3T3-L1	3t3-l1	NN	NN	_	9	compound	_	_
9	adipocytes	adipocyte	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	increased	increase	VBD	VBD	_	2	conj	_	_
12	the	the	DT	DT	_	14	det	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	fatty	fatty	JJ	JJ	_	18	amod	_	_
17	acid-binding	acid-binding	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	YM268	ym268	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	8	punct	_	_
3	with	with	IN	IN	_	6	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	without	without	IN	IN	_	3	conj	_	_
6	insulin	insulin	NN	NN	_	8	nmod	_	_
7	,	,	,	,	_	8	punct	_	_
8	increased	increase	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	glucose	glucose	NN	NN	_	15	compound	_	_
14	transporter	transporter	NN	NN	_	15	compound	_	_
15	isoforms	isoform	NNS	NNS	_	11	nmod	_	_
16	such	such	JJ	JJ	_	18	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	GLUT1	glut1	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	GLUT4	glut4	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	8	punct	_	_
22	indicating	indicate	VBG	VBG	_	8	advcl	_	_
23	enhancement	enhancement	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	adipocyte	adipocyte	NN	NN	_	26	compound	_	_
26	differentiation	differentiation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Additionally	additionally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	YM268	ym268	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	pioglitazone	pioglitazone	NN	NN	_	3	conj	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	activity	activity	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	PPARgamma	ppargamma	NN	NN	_	11	compound	_	_
11	ligand	ligand	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	member	member	NN	NN	_	11	appos	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	superfamily	superfamily	NN	NN	_	14	nmod	_	_
20	responsible	responsible	JJ	JJ	_	19	amod	_	_
21	for	for	IN	IN	_	22	case	_	_
22	adipogenesis	adipogenesis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	22	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	possible	possible	JJ	JJ	_	5	amod	_	_
5	involvement	involvement	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	PI	pi	NN	NN	_	12	compound	_	_
12	3-kinase	3-kinase	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	YM268-stimulated	ym268-stimulated	JJ	JJ	_	16	amod	_	_
15	glucose	glucose	NN	NN	_	16	compound	_	_
16	uptake	uptake	NN	NN	_	5	nmod	_	_
17	,	,	,	,	_	22	punct	_	_
18	the	the	DT	DT	_	20	det	_	_
19	enzyme	enzyme	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	estimated	estimate	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	measuring	measure	VBG	VBG	_	22	advcl	_	_
25	the	the	DT	DT	_	30	det	_	_
26	phosphatidylinositol-3,4,5-trisphosphate	phosphatidylinositol-3,4,5-trisphosphate	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PI-3,4,5-P3	pi-3,4,5-p3	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	concentration	concentration	NN	NN	_	24	dobj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	monocytic	monocytic	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	22	punct	_	_

1	Insulin	insulin	NN	NN	_	3	nsubj	_	_
2	dose-dependently	dose-dependently	RB	RB	_	3	advmod	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	PI-3,4,5-P3	pi-3,4,5-p3	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	3	dobj	_	_
7	but	but	CC	CC	_	3	cc	_	_
8	YM268	ym268	NN	NN	_	9	nsubj	_	_
9	had	have	VBD	VBD	_	3	conj	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	9	dobj	_	_
13	on	on	IN	IN	_	20	case	_	_
14	the	the	DT	DT	_	20	det	_	_
15	insulin-dependent	insulin-dependent	JJ	JJ	_	20	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	-independent	-independent	JJ	JJ	_	15	conj	_	_
18	PI	pi	NN	NN	_	20	compound	_	_
19	3-kinase	3-kinase	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	9	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	16	nsubjpass	_	_
7	by	by	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	10	nmod	_	_
9	YM268	ym268	NN	NN	_	10	nsubj	_	_
10	increased	increase	VBD	VBD	_	6	acl:relcl	_	_
11	glucose	glucose	NN	NN	_	12	compound	_	_
12	uptake	uptake	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	16	punct	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	accounted	account	VBN	VBN	_	3	ccomp	_	_
17	for	for	IN	IN	_	16	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	22	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	enhancement	enhancement	NN	NN	_	16	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	GLUT1	glut1	NN	NN	_	27	compound	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	GLUT4	glut4	NN	NN	_	24	conj	_	_
27	expression	expression	NN	NN	_	22	nmod	_	_
28	through	through	IN	IN	_	30	case	_	_
29	PPARgamma	ppargamma	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	22	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	oestrogen	oestrogen	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	variants	variant	NNS	NNS	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	endometrium	endometrium	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	myometrium	myometrium	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	leiomyoma	leiomyoma	NN	NN	_	7	conj	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	7	conj	_	_
17	:	:	:	:	_	1	punct	_	_
18	comparison	comparison	NN	NN	_	1	dep	_	_
19	to	to	TO	TO	_	20	case	_	_
20	variants	variant	NNS	NNS	_	18	nmod	_	_
21	present	present	JJ	JJ	_	20	amod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	breast	breast	NN	NN	_	24	compound	_	_
24	cancer	cancer	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Oestradiol	oestradiol	NN	NN	_	2	nsubj	_	_
2	has	have	VBZ	VBZ	_	0	root	_	_
3	mitogenic	mitogenic	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	regulatory	regulatory	JJ	JJ	_	3	conj	_	_
6	effects	effect	NNS	NNS	_	2	dobj	_	_
7	on	on	IN	IN	_	9	case	_	_
8	various	various	JJ	JJ	_	9	amod	_	_
9	organs	organ	NNS	NNS	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	cells	cell	NNS	NNS	_	9	conj	_	_
12	,	,	,	,	_	2	punct	_	_
13	mediated	mediate	VBN	VBN	_	2	advcl	_	_
14	mainly	mainly	RB	RB	_	18	advmod	_	_
15	by	by	IN	IN	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	receptor	receptor	NN	NN	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	ER	er	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	aberrant	aberrant	JJ	JJ	_	6	amod	_	_
5	ER	er	NN	NN	_	6	compound	_	_
6	forms	form	NNS	NNS	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	Oestrogen-dependent	oestrogen-dependent	JJ	JJ	_	9	amod	_	_
9	tumours	tumour	NNS	NNS	_	2	nmod	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	discussed	discuss	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	correlation	correlation	NN	NN	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	tumour	tumour	NN	NN	_	17	compound	_	_
17	progression	progression	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	ER	er	NN	NN	_	2	compound	_	_
2	variants	variant	NNS	NNS	_	11	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	generated	generate	VBN	VBN	_	2	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	alternative	alternative	JJ	JJ	_	7	amod	_	_
7	splicing	splicing	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	2	punct	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	detected	detect	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	breast	breast	NN	NN	_	15	compound	_	_
15	cancer	cancer	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	15	cc	_	_
18	also	also	RB	RB	_	22	advmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	normal	normal	JJ	JJ	_	22	amod	_	_
21	mammary	mammary	JJ	JJ	_	22	amod	_	_
22	glands	gland	NNS	NNS	_	15	conj	_	_
23	,	,	,	,	_	11	punct	_	_
24	therefore	therefore	RB	RB	_	11	advmod	_	_
25	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
26	role	role	NN	NN	_	31	nsubjpass	_	_
27	in	in	IN	IN	_	28	case	_	_
28	tumorigenesis	tumorigenesis	NN	NN	_	26	nmod	_	_
29	has	have	VBZ	VBZ	_	31	aux	_	_
30	been	be	VBN	VBN	_	31	auxpass	_	_
31	questioned	question	VBN	VBN	_	11	parataxis	_	_
32	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	by	by	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	det	_	_
10	reverse	reverse	JJ	JJ	_	16	amod	_	_
11	transcription	transcription	NN	NN	_	16	compound	_	_
12	polymerase	polymerase	NN	NN	_	16	compound	_	_
13	chain	chain	NN	NN	_	16	compound	_	_
14	reaction	reaction	NN	NN	_	16	compound	_	_
15	amplification	amplification	NN	NN	_	16	compound	_	_
16	technique	technique	NN	NN	_	7	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	the	the	DT	DT	_	20	det	_	_
19	possible	possible	JJ	JJ	_	20	amod	_	_
20	existence	existence	NN	NN	_	3	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	ER	er	NN	NN	_	23	compound	_	_
23	variants	variant	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	other	other	JJ	JJ	_	28	amod	_	_
26	normal	normal	JJ	JJ	_	28	amod	_	_
27	oestrogen	oestrogen	NN	NN	_	28	compound	_	_
28	target	target	NN	NN	_	20	nmod	_	_
29	organs	organ	NNS	NNS	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	cells	cell	NNS	NNS	_	29	conj	_	_
32	,	,	,	,	_	28	punct	_	_
33	such	such	JJ	JJ	_	35	case	_	_
34	as	as	IN	IN	_	33	mwe	_	_
35	uterus	uterus	NN	NN	_	28	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	myometrium	myometrium	NN	NN	_	35	dep	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	endometrium	endometrium	NN	NN	_	37	conj	_	_
40	)	)	-RRB-	-RRB-	_	37	punct	_	_
41	,	,	,	,	_	28	punct	_	_
42	in	in	IN	IN	_	46	case	_	_
43	peripheral	peripheral	JJ	JJ	_	46	amod	_	_
44	blood	blood	NN	NN	_	46	compound	_	_
45	mononuclear	mononuclear	JJ	JJ	_	46	amod	_	_
46	cells	cell	NNS	NNS	_	28	conj	_	_
47	and	and	CC	CC	_	28	cc	_	_
48	in	in	IN	IN	_	52	case	_	_
49	a	a	DT	DT	_	52	det	_	_
50	benign	benign	JJ	JJ	_	52	amod	_	_
51	uterus	uterus	NN	NN	_	52	compound	_	_
52	tumour	tumour	NN	NN	_	28	conj	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	leiomyoma	leiomyoma	NN	NN	_	52	appos	_	_
55	)	)	-RRB-	-RRB-	_	54	punct	_	_
56	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	detected	detect	VBN	VBN	_	0	root	_	_
4	variant	variant	JJ	JJ	_	5	amod	_	_
5	ER	er	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	samples	sample	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	have	have	VBP	VBP	_	11	aux	_	_
11	compared	compare	VBN	VBN	_	3	conj	_	_
12	the	the	DT	DT	_	14	det	_	_
13	variant	variant	JJ	JJ	_	14	amod	_	_
14	profile	profile	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	that	that	DT	DT	_	11	nmod	_	_
17	observed	observe	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	breast	breast	NN	NN	_	20	compound	_	_
20	cancer	cancer	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	tissues	tissue	NNS	NNS	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cells	cell	NNS	NNS	_	2	conj	_	_
5	studied	study	VBN	VBN	_	2	acl	_	_
6	expressed	express	VBD	VBD	_	0	root	_	_
7	both	both	CC	CC	_	9	cc:preconj	_	_
8	wild-type	wild-type	JJ	JJ	_	9	amod	_	_
9	ER	er	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	variant	variant	JJ	JJ	_	12	amod	_	_
12	species	species	NNS	NNS	_	9	conj	_	_
13	.	.	.	.	_	6	punct	_	_

1	Variant	variant	JJ	JJ	_	2	amod	_	_
2	forms	form	NNS	NNS	_	3	nsubj	_	_
3	encompassed	encompass	VBD	VBD	_	0	root	_	_
4	ER	er	NN	NN	_	3	dobj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	deletions	deletion	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	exons	exon	NNS	NNS	_	6	nmod	_	_
9	2	2	CD	CD	_	8	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	5	5	CD	CD	_	9	conj	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	7	7	CD	CD	_	9	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Variants	variant	NNS	NNS	_	7	nsubjpass	_	_
2	with	with	IN	IN	_	5	mark	_	_
3	exon	exon	NN	NN	_	5	nsubj	_	_
4	5	5	CD	CD	_	3	nummod	_	_
5	deleted	delete	VBN	VBN	_	1	acl:relcl	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	only	only	RB	RB	_	7	advcl	_	_
9	in	in	IN	IN	_	13	case	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	in	in	IN	IN	_	17	case	_	_
16	breast	breast	NN	NN	_	17	compound	_	_
17	cancer	cancer	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Variants	variant	NNS	NNS	_	9	nsubj	_	_
2	with	with	IN	IN	_	7	mark	_	_
3	exons	exon	NNS	NNS	_	7	nsubj	_	_
4	2	2	CD	CD	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	7	7	CD	CD	_	4	conj	_	_
7	deleted	delete	VBN	VBN	_	1	acl:relcl	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	present	present	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	all	all	DT	DT	_	12	det	_	_
12	specimens	specimen	NNS	NNS	_	9	nmod	_	_
13	tested	test	VBN	VBN	_	12	acl	_	_
14	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	corroborate	corroborate	VBP	VBP	_	0	root	_	_
4	previous	previous	JJ	JJ	_	5	amod	_	_
5	findings	finding	NNS	NNS	_	3	dobj	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	15	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ER	er	NN	NN	_	11	compound	_	_
11	variants	variant	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	15	cop	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	a	a	DT	DT	_	15	det	_	_
15	characteristic	characteristic	NN	NN	_	5	ccomp	_	_
16	of	of	IN	IN	_	18	case	_	_
17	breast	breast	NN	NN	_	18	compound	_	_
18	cancer	cancer	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	physiological	physiological	JJ	JJ	_	3	amod	_	_
3	significance	significance	NN	NN	_	13	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	possible	possible	JJ	JJ	_	7	amod	_	_
6	clinical	clinical	JJ	JJ	_	7	amod	_	_
7	relevance	relevance	NN	NN	_	3	conj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	variant	variant	JJ	JJ	_	12	amod	_	_
11	ER	er	NN	NN	_	12	compound	_	_
12	forms	form	NNS	NNS	_	3	nmod	_	_
13	remain	remain	VBP	VBP	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	elucidated	elucidate	VBN	VBN	_	13	xcomp	_	_
17	.	.	.	.	_	13	punct	_	_

1	Interaction	interaction	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	sickle	sickle	NN	NN	_	4	compound	_	_
4	erythrocytes	erythrocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	dep	_	_
10	presence	presence	NN	NN	_	15	dep	_	_
11	of	of	IN	IN	_	15	case	_	_
12	endothelial	endothelial	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	nmod:npmod	_	_
14	conditioned	conditioned	JJ	JJ	_	15	amod	_	_
15	medium	medium	NN	NN	_	1	nmod	_	_
16	induces	induce	VBZ	VBZ	_	0	root	_	_
17	oxidant	oxidant	JJ	JJ	_	18	amod	_	_
18	stress	stress	NN	NN	_	16	dobj	_	_
19	leading	lead	VBG	VBG	_	18	acl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	transendothelial	transendothelial	JJ	JJ	_	22	amod	_	_
22	migration	migration	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	monocytes	monocyte	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	abnormal	abnormal	JJ	JJ	_	3	amod	_	_
3	adherence	adherence	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	sickle	sickle	NN	NN	_	8	compound	_	_
6	red	red	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	SS	ss	NN	NN	_	11	compound	_	_
11	RBC	rbc	NNS	NNS	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	to	to	TO	TO	_	15	case	_	_
14	endothelial	endothelial	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	3	nmod	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	thought	think	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	contribute	contribute	VB	VB	_	18	xcomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	vascular	vascular	JJ	JJ	_	23	amod	_	_
23	occlusion	occlusion	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	a	a	DT	DT	_	27	det	_	_
26	major	major	JJ	JJ	_	27	amod	_	_
27	cause	cause	NN	NN	_	23	appos	_	_
28	of	of	IN	IN	_	29	case	_	_
29	morbidity	morbidity	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	sickle	sickle	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	disease	disease	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	SCD	scd	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	determined	determine	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	interaction	interaction	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	SS	ss	NN	NN	_	8	compound	_	_
8	RBC	rbc	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	cultured	culture	VBN	VBN	_	12	amod	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	induced	induce	VBD	VBD	_	2	ccomp	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	oxidant	oxidant	JJ	JJ	_	16	amod	_	_
16	stress	stress	NN	NN	_	13	dobj	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	would	would	MD	MD	_	19	aux	_	_
19	culminate	culminate	VB	VB	_	16	acl:relcl	_	_
20	in	in	IN	IN	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	adhesion	adhesion	NN	NN	_	25	compound	_	_
25	molecules	molecule	NNS	NNS	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CAMs	cam	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	involved	involve	VBN	VBN	_	25	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	adhesion	adhesion	NN	NN	_	29	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	diapedesis	diapedesis	NN	NN	_	32	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
37	and	and	CC	CC	_	32	cc	_	_
38	the	the	DT	DT	_	39	det	_	_
39	adherence	adherence	NN	NN	_	32	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	SS	ss	NN	NN	_	42	compound	_	_
42	reticulocytes	reticulocyte	NNS	NNS	_	39	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	showed	show	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	46	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	interaction	interaction	NN	NN	_	46	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	SS	ss	NN	NN	_	8	compound	_	_
8	RBC	rbc	NNS	NNS	_	5	nmod	_	_
9	at	at	IN	IN	_	12	case	_	_
10	2	2	CD	CD	_	11	compound	_	_
11	%	%	NN	NN	_	12	amod	_	_
12	concentration	concentration	NN	NN	_	5	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	dep	_	_
15	presence	presence	NN	NN	_	17	dep	_	_
16	of	of	IN	IN	_	17	case	_	_
17	multimers	multimer	NNS	NNS	_	5	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	von	von	NN	NN	_	21	compound	_	_
20	Willebrand	willebrand	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	vWf	vwf	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	17	punct	_	_
26	derived	derive	VBN	VBN	_	17	acl	_	_
27	from	from	IN	IN	_	31	case	_	_
28	endothelial	endothelial	JJ	JJ	_	29	amod	_	_
29	cell-derived	cell-derived	JJ	JJ	_	31	amod	_	_
30	conditioned	condition	VBN	VBN	_	31	amod	_	_
31	medium	medium	NN	NN	_	26	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	E-CM	e-cm	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	with	with	IN	IN	_	41	case	_	_
36	cultured	culture	VBN	VBN	_	41	amod	_	_
37	human	human	JJ	JJ	_	41	amod	_	_
38	umbilical	umbilical	JJ	JJ	_	41	amod	_	_
39	vein	vein	NN	NN	_	41	compound	_	_
40	endothelial	endothelial	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	31	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	HUVEC	huvec	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	17	punct	_	_
46	resulted	result	VBD	VBD	_	2	ccomp	_	_
47	in	in	IN	IN	_	51	case	_	_
48	a	a	DT	DT	_	51	det	_	_
49	fivefold	fivefold	RB	RB	_	51	advmod	_	_
50	increased	increase	VBN	VBN	_	51	amod	_	_
51	formation	formation	NN	NN	_	46	nmod	_	_
52	of	of	IN	IN	_	55	case	_	_
53	thiobarbituric	thiobarbituric	JJ	JJ	_	55	amod	_	_
54	acid-reactive	acid-reactive	JJ	JJ	_	55	amod	_	_
55	substances	substance	NNS	NNS	_	51	nmod	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	TBARS	tbar	NNS	NNS	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	and	and	CC	CC	_	51	cc	_	_
60	activation	activation	NN	NN	_	51	conj	_	_
61	of	of	IN	IN	_	65	case	_	_
62	the	the	DT	DT	_	65	det	_	_
63	transcription	transcription	NN	NN	_	65	compound	_	_
64	factor	factor	NN	NN	_	65	compound	_	_
65	NF-kB	nf-kb	NN	NN	_	60	nmod	_	_
66	,	,	,	,	_	51	punct	_	_
67	both	both	DT	DT	_	68	advmod	_	_
68	indicators	indicator	NNS	NNS	_	51	appos	_	_
69	of	of	IN	IN	_	72	case	_	_
70	cellular	cellular	JJ	JJ	_	72	amod	_	_
71	oxidant	oxidant	JJ	JJ	_	72	amod	_	_
72	stress	stress	NN	NN	_	68	nmod	_	_
73	.	.	.	.	_	2	punct	_	_

1	Normal	normal	JJ	JJ	_	2	amod	_	_
2	RBC	rbc	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	none	none	DT	DT	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	phenomena	phenomenon	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	oxidant	oxidant	JJ	JJ	_	3	amod	_	_
3	stress-induced	stress-induced	JJ	JJ	_	4	amod	_	_
4	signaling	signaling	NN	NN	_	5	nsubj	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	an	a	DT	DT	_	10	det	_	_
8	increased	increase	VBN	VBN	_	10	amod	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	subset	subset	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	CAMs	cam	NNS	NNS	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	ICAM-1	icam-1	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	17	punct	_	_
19	E-selectin	e-selectin	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	VCAM-1	vcam-1	NN	NN	_	17	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	HUVEC	huvec	NN	NN	_	10	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	oxygen	oxygen	NN	NN	_	7	compound	_	_
5	radical	radical	JJ	JJ	_	7	amod	_	_
6	scavenger	scavenger	NN	NN	_	7	compound	_	_
7	enzymes	enzyme	NNS	NNS	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	catalase	catalase	NN	NN	_	7	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	superoxide	superoxide	NN	NN	_	12	compound	_	_
12	dismutase	dismutase	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	antioxidant	antioxidant	NN	NN	_	7	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	probucol	probucol	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	inhibited	inhibit	VBD	VBD	_	0	root	_	_
20	these	these	DT	DT	_	21	det	_	_
21	events	event	NNS	NNS	_	19	dobj	_	_
22	.	.	.	.	_	19	punct	_	_

1	Additionally	additionally	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	preincubation	preincubation	NN	NN	_	21	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HUVEC	huvec	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	synthetic	synthetic	JJ	JJ	_	10	amod	_	_
9	peptide	peptide	NN	NN	_	10	compound	_	_
10	Arg-Gly-Asp	arg-gly-asp	NN	NN	_	3	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RGD	rgd	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	prevents	prevent	VBZ	VBZ	_	10	acl:relcl	_	_
16	vWf-mediated	vwf-mediated	JJ	JJ	_	17	amod	_	_
17	adhesion	adhesion	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	SS	ss	NN	NN	_	20	compound	_	_
20	RBC	rbc	NNS	NNS	_	17	nmod	_	_
21	reduced	reduce	VBD	VBD	_	0	root	_	_
22	the	the	DT	DT	_	24	det	_	_
23	surface	surface	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	VCAM-1	vcam-1	NN	NN	_	29	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	NF-kB	nf-kb	NN	NN	_	26	conj	_	_
29	activation	activation	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	21	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	SS	ss	NN	NN	_	4	nmod:npmod	_	_
4	RBC-induced	rbc-induced	JJ	JJ	_	6	amod	_	_
5	oxidant	oxidant	JJ	JJ	_	6	amod	_	_
6	stress	stress	NN	NN	_	7	nsubj	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	twofold	twofold	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transendothelial	transendothelial	JJ	JJ	_	15	amod	_	_
15	migration	migration	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	both	both	CC	CC	_	20	cc:preconj	_	_
18	monocyte-like	monocyte-like	JJ	JJ	_	20	amod	_	_
19	HL-60	hl-60	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
24	blood	blood	NN	NN	_	25	compound	_	_
25	monocytes	monocyte	NNS	NNS	_	20	conj	_	_
26	,	,	,	,	_	11	punct	_	_
27	and	and	CC	CC	_	11	cc	_	_
28	approximately	approximately	RB	RB	_	31	advmod	_	_
29	a	a	DT	DT	_	31	det	_	_
30	sixfold	sixfold	JJ	JJ	_	31	amod	_	_
31	increase	increase	NN	NN	_	11	conj	_	_
32	in	in	IN	IN	_	40	case	_	_
33	platelet-endothelial	platelet-endothelial	JJ	JJ	_	36	amod	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	adhesion	adhesion	NN	NN	_	36	compound	_	_
36	molecule-1	molecule-1	NN	NN	_	40	compound	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	PECAM-1	pecam-1	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	phosphorylation	phosphorylation	NN	NN	_	31	nmod	_	_
41	,	,	,	,	_	11	punct	_	_
42	each	each	DT	DT	_	46	nsubjpass	_	_
43	of	of	IN	IN	_	44	case	_	_
44	which	which	WDT	WDT	_	42	nmod	_	_
45	was	be	VBD	VBD	_	46	auxpass	_	_
46	blocked	block	VBN	VBN	_	11	acl:relcl	_	_
47	by	by	IN	IN	_	51	case	_	_
48	protein	protein	NN	NN	_	51	compound	_	_
49	kinase	kinase	NN	NN	_	51	compound	_	_
50	C	c	NN	NN	_	51	compound	_	_
51	inhibitor	inhibitor	NN	NN	_	46	nmod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	antioxidants	antioxidant	NNS	NNS	_	51	conj	_	_
54	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	adherence/contact	adherence/contact	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	SS	ss	NN	NN	_	9	compound	_	_
9	RBC	rbc	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	large	large	JJ	JJ	_	15	amod	_	_
15	vessel	vessel	NN	NN	_	12	nmod	_	_
16	can	can	MD	MD	_	17	aux	_	_
17	generate	generate	VB	VB	_	3	ccomp	_	_
18	enhanced	enhance	VBN	VBN	_	20	amod	_	_
19	oxidant	oxidant	JJ	JJ	_	20	amod	_	_
20	stress	stress	NN	NN	_	17	dobj	_	_
21	leading	lead	VBG	VBG	_	20	acl	_	_
22	to	to	TO	TO	_	24	case	_	_
23	increased	increase	VBN	VBN	_	24	amod	_	_
24	adhesion	adhesion	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	diapedesis	diapedesis	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	as	as	RB	RB	_	20	cc	_	_
31	well	well	RB	RB	_	30	mwe	_	_
32	as	as	IN	IN	_	30	mwe	_	_
33	heightened	heighten	VBN	VBN	_	34	amod	_	_
34	adherence	adherence	NN	NN	_	20	conj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	SS	ss	NN	NN	_	37	compound	_	_
37	reticulocytes	reticulocyte	NNS	NNS	_	34	nmod	_	_
38	,	,	,	,	_	17	punct	_	_
39	indicating	indicate	VBG	VBG	_	17	advcl	_	_
40	that	that	IN	IN	_	45	mark	_	_
41	injury/activation	injury/activation	NN	NN	_	45	nsubj	_	_
42	of	of	IN	IN	_	43	case	_	_
43	endothelium	endothelium	NN	NN	_	41	nmod	_	_
44	can	can	MD	MD	_	45	aux	_	_
45	contribute	contribute	VB	VB	_	39	ccomp	_	_
46	to	to	TO	TO	_	47	case	_	_
47	vaso-occlusion	vaso-occlusion	NN	NN	_	45	nmod	_	_
48	in	in	IN	IN	_	49	case	_	_
49	SCD	scd	NN	NN	_	47	nmod	_	_
50	.	.	.	.	_	3	punct	_	_

1	Interleukin	interleukin	NN	NN	_	5	nsubj	_	_
2	2	2	CD	CD	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	15	15	CD	CD	_	2	conj	_	_
5	activate	activate	VBP	VBP	_	0	root	_	_
6	Stat3alpha	stat3alpha	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Signal	signal	NN	NN	_	14	nsubjpass	_	_
2	transducer	transducer	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activator	activator	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	transcription	transcription	NN	NN	_	1	nmod	_	_
7	3	3	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	Stat3	stat3	NN	NN	_	1	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	has	have	VBZ	VBZ	_	14	aux	_	_
12	recently	recently	RB	RB	_	14	advmod	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	exist	exist	VB	VB	_	14	xcomp	_	_
17	in	in	IN	IN	_	21	case	_	_
18	two	two	CD	CD	_	21	nummod	_	_
19	alternatively	alternatively	RB	RB	_	20	advmod	_	_
20	spliced	splice	VBN	VBN	_	21	amod	_	_
21	isoforms	isoform	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	25	det	_	_
24	short	short	JJ	JJ	_	25	amod	_	_
25	form	form	NN	NN	_	21	appos	_	_
26	,	,	,	,	_	25	punct	_	_
27	Stat3beta	stat3beta	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	a	a	DT	DT	_	32	det	_	_
31	longer	longer	JJR	JJR	_	32	amod	_	_
32	form	form	NN	NN	_	25	conj	_	_
33	,	,	,	,	_	32	punct	_	_
34	Stat3alpha	stat3alpha	NN	NN	_	32	appos	_	_
35	,	,	,	,	_	32	punct	_	_
36	displaying	display	VBG	VBG	_	21	acl	_	_
37	differences	difference	NNS	NNS	_	36	dobj	_	_
38	in	in	IN	IN	_	40	case	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	14	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	unknown	unknown	JJ	JJ	_	0	root	_	_
4	which	which	WDT	WDT	_	8	det	_	_
5	Stat3	stat3	NN	NN	_	8	compound	_	_
6	isoform	isoform	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	11	nsubjpass	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	activated	activate	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	17	case	_	_
13	response	response	NN	NN	_	17	dep	_	_
14	to	to	TO	TO	_	17	case	_	_
15	interleukin	interleukin	NN	NN	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IL	il	NN	NN	_	11	nmod	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	-2	-2	CD	CD	_	17	nummod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	IL-15	il-15	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	cytokine-induced	cytokine-induced	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	15	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Stat3	stat3	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	13	case	_	_
8	previously	previously	RB	RB	_	9	advmod	_	_
9	activated	activate	VBN	VBN	_	13	amod	_	_
10	CD4(+)	cd4(+)	JJ	JJ	_	13	amod	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	examined	examine	VBN	VBN	_	0	root	_	_
16	using	use	VBG	VBG	_	15	xcomp	_	_
17	Stat3	stat3	NN	NN	_	18	compound	_	_
18	antibodies	antibody	NNS	NNS	_	16	dobj	_	_
19	directed	direct	VBN	VBN	_	18	acl	_	_
20	against	against	IN	IN	_	22	case	_	_
21	different	different	JJ	JJ	_	22	amod	_	_
22	regions	region	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Stat3	stat3	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	determined	determine	VBN	VBN	_	19	advcl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	translocation	translocation	NN	NN	_	5	conj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	binding	bind	VBG	VBG	_	5	conj	_	_
11	to	to	TO	TO	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	hSIE-oligonucleotide	hsie-oligonucleotide	NN	NN	_	14	compound	_	_
14	probe	probe	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	IL-2	il-2	NN	NN	_	19	nsubj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-15	il-15	NN	NN	_	16	conj	_	_
19	activated	activate	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	23	det	_	_
21	slowly	slowly	RB	RB	_	22	advmod	_	_
22	migrating	migrate	VBG	VBG	_	23	amod	_	_
23	isoform	isoform	NN	NN	_	19	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	Stat3alpha	stat3alpha	NN	NN	_	23	appos	_	_
26	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	minimal	minimal	JJ	JJ	_	11	nsubjpass	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	no	no	DT	DT	_	4	conj	_	_
7	activation	activation	NN	NN	_	4	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Stat3beta	stat3beta	NN	NN	_	4	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	IL-2	il-2	NN	NN	_	19	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IL-15	il-15	NN	NN	_	15	conj	_	_
18	predominantly	predominantly	RB	RB	_	19	advmod	_	_
19	activate	activate	VBP	VBP	_	13	ccomp	_	_
20	Stat3alpha	stat3alpha	NN	NN	_	19	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	human	human	JJ	JJ	_	25	amod	_	_
23	CD4(+)	cd4(+)	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	way	way	NN	NN	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	diversity	diversity	NN	NN	_	15	nsubj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	activation	activation	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Stat3	stat3	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	8	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	provide	provide	VB	VB	_	0	root	_	_
16	additional	additional	JJ	JJ	_	17	amod	_	_
17	means	means	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	regulating	regulate	VBG	VBG	_	17	acl	_	_
20	cytokine-induced	cytokine-induced	JJ	JJ	_	23	amod	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	responses	response	NNS	NNS	_	19	dobj	_	_
24	.	.	.	.	_	15	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	sequence	sequence	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	exon:intron	exon:intron	JJ	JJ	_	5	amod	_	_
5	structure	structure	NN	NN	_	2	conj	_	_
6	,	,	,	,	_	2	punct	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	synteny	synteny	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	genetic	genetic	JJ	JJ	_	11	amod	_	_
11	location	location	NN	NN	_	8	nmod	_	_
12	show	show	VBP	VBP	_	0	root	_	_
13	that	that	IN	IN	_	22	mark	_	_
14	a	a	DT	DT	_	16	det	_	_
15	chicken	chicken	NN	NN	_	16	compound	_	_
16	cytokine	cytokine	NN	NN	_	22	nsubj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	T-cell	t-cell	NN	NN	_	20	compound	_	_
19	proliferative	proliferative	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	IL2	il2	NN	NN	_	12	ccomp	_	_
23	and	and	CC	CC	_	24	cc	_	_
24	not	not	RB	RB	_	22	cc	_	_
25	IL15	il15	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	12	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	chicken	chicken	NN	NN	_	6	compound	_	_
6	cytokine	cytokine	NN	NN	_	3	dobj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	T-cell	t-cell	NN	NN	_	10	compound	_	_
9	proliferative	proliferative	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	cloned	clone	VBN	VBN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	sequenced	sequence	VBN	VBN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	mapped	map	VBN	VBN	_	12	conj	_	_
18	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	cytokine	cytokine	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	chicken	chicken	NN	NN	_	9	compound	_	_
9	IL2	il2	NN	NN	_	3	ccomp	_	_
10	and	and	CC	CC	_	11	cc	_	_
11	not	not	RB	RB	_	9	cc	_	_
12	IL15	il15	NN	NN	_	9	conj	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	exon:intron	exon:intron	JJ	JJ	_	3	amod	_	_
3	structure	structure	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	chicken	chicken	NN	NN	_	6	compound	_	_
6	IL2	il2	NN	NN	_	3	nmod	_	_
7	corresponds	correspond	VBZ	VBZ	_	0	root	_	_
8	almost	almost	RB	RB	_	9	advmod	_	_
9	exactly	exactly	RB	RB	_	7	advmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	those	those	DT	DT	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	mammalian	mammalian	JJ	JJ	_	14	amod	_	_
14	IL2s	il2	NNS	NNS	_	11	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	exceptions	exception	NNS	NNS	_	7	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	exon	exon	NN	NN	_	17	nmod	_	_
20	2	2	CD	CD	_	19	nummod	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	introns	intron	NNS	NNS	_	19	conj	_	_
23	2	2	CD	CD	_	22	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	3	3	CD	CD	_	23	conj	_	_
26	which	which	WDT	WDT	_	28	nsubj	_	_
27	are	be	VBP	VBP	_	28	cop	_	_
28	shorter	shorter	JJR	JJR	_	19	acl:relcl	_	_
29	.	.	.	.	_	7	punct	_	_

1	Chicken	chicken	NN	NN	_	2	compound	_	_
2	IL2	il2	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	five	five	CD	CD	_	5	nummod	_	_
5	repeats	repeat	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	``	``	``	``	_	11	punct	_	_
9	instability	instability	NN	NN	_	11	compound	_	_
10	motif	motif	NN	NN	_	11	compound	_	_
11	ATTTA	attta	NN	NN	_	5	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	3'	3'	JJ	JJ	_	16	amod	_	_
15	untranslated	untranslated	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	3	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	exon	exon	NN	NN	_	16	nmod	_	_
19	4	4	CD	CD	_	18	nummod	_	_
20	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	single-copy	single-copy	JJ	JJ	_	5	amod	_	_
5	gene	gene	NN	NN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	with	with	IN	IN	_	18	mark	_	_
8	neither	neither	CC	CC	_	17	dep	_	_
9	structural	structural	JJ	JJ	_	8	dep	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	amino	amino	NN	NN	_	12	compound	_	_
12	acid	acid	NN	NN	_	9	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	nor	nor	CC	CC	_	8	cc	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	sequence	sequence	NN	NN	_	8	conj	_	_
17	polymorphisms	polymorphism	NNS	NNS	_	18	nsubj	_	_
18	identified	identify	VBN	VBN	_	5	acl:relcl	_	_
19	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	predicted	predict	VBN	VBN	_	7	amod	_	_
5	amino	amino	NN	NN	_	7	compound	_	_
6	acid	acid	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	suggests	suggest	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	overall	overall	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	structure	structure	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	conserved	conserve	VBN	VBN	_	8	ccomp	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	the	the	DT	DT	_	20	det	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	21	nsubj	_	_
21	are	be	VBP	VBP	_	14	conj	_	_
22	not	not	RB	RB	_	21	neg	_	_
23	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	potential	potential	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	sequences	sequence	NNS	NNS	_	2	nmod	_	_
7	similar	similar	JJ	JJ	_	6	amod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	those	those	DT	DT	_	7	nmod	_	_
10	found	find	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	mammals	mammal	NNS	NNS	_	10	nmod	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	identified	identify	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	promoter	promoter	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	include	include	VBP	VBP	_	0	root	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	5'-3'	5'-3'	JJ	JJ	_	2	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	a	a	DT	DT	_	11	det	_	_
7	composite	composite	JJ	JJ	_	11	amod	_	_
8	NF-AT/	nf-at/	JJ	JJ	_	11	amod	_	_
9	``	``	``	``	_	11	punct	_	_
10	AP-1	ap-1	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	2	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	16	det	_	_
14	CD28	cd28	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	11	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	an	a	DT	DT	_	20	det	_	_
19	AP-1	ap-1	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	11	conj	_	_
21	,	,	,	,	_	11	punct	_	_
22	an	a	DT	DT	_	24	det	_	_
23	NF-AT	nf-at	NN	NN	_	24	compound	_	_
24	element	element	NN	NN	_	11	conj	_	_
25	,	,	,	,	_	11	punct	_	_
26	and	and	CC	CC	_	11	cc	_	_
27	the	the	DT	DT	_	34	det	_	_
28	AP-1	ap-1	NN	NN	_	34	compound	_	_
29	part	part	NN	NN	_	34	compound	_	_
30	of	of	IN	IN	_	34	amod	_	_
31	an	a	DT	DT	_	34	det	_	_
32	AP-1/octamer	ap-1/octamer	NN	NN	_	34	compound	_	_
33	composite	composite	JJ	JJ	_	34	amod	_	_
34	element	element	NN	NN	_	11	conj	_	_
35	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mammalian	mammalian	JJ	JJ	_	3	amod	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	octamer	octamer	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	3	conj	_	_
8	seem	seem	VBP	VBP	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	absent	absent	JJ	JJ	_	8	xcomp	_	_
12	,	,	,	,	_	11	punct	_	_
13	although	although	IN	IN	_	15	mark	_	_
14	there	there	EX	EX	_	15	expl	_	_
15	are	be	VBP	VBP	_	11	advcl	_	_
16	alternative	alternative	JJ	JJ	_	21	amod	_	_
17	potential	potential	JJ	JJ	_	21	amod	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	21	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	octamer-binding	octamer-binding	JJ	JJ	_	18	conj	_	_
21	elements	element	NNS	NNS	_	15	nsubj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	chicken	chicken	NN	NN	_	26	compound	_	_
25	IL2	il2	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	15	nmod	_	_
27	,	,	,	,	_	15	punct	_	_
28	in	in	IN	IN	_	30	case	_	_
29	close	close	JJ	JJ	_	30	amod	_	_
30	proximity	proximity	NN	NN	_	15	nmod	_	_
31	to	to	TO	TO	_	34	case	_	_
32	their	they	PRP$	PRP$	_	34	nmod:poss	_	_
33	mammalian	mammalian	JJ	JJ	_	34	amod	_	_
34	homologues	homologue	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	comparisons	comparison	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	predict	predict	VBP	VBP	_	0	root	_	_
5	other	other	JJ	JJ	_	10	amod	_	_
6	potential	potential	JJ	JJ	_	10	amod	_	_
7	transcription	transcription	NN	NN	_	9	dep	_	_
8	factor	factor	NN	NN	_	9	dep	_	_
9	binding	binding	NN	NN	_	10	amod	_	_
10	sites	site	NNS	NNS	_	4	dobj	_	_
11	as	as	IN	IN	_	12	case	_	_
12	yet	yet	RB	RB	_	13	advmod	_	_
13	undescribed	undescribed	JJ	JJ	_	10	dep	_	_
14	in	in	IN	IN	_	17	case	_	_
15	mammalian	mammalian	JJ	JJ	_	17	amod	_	_
16	IL2	il2	NN	NN	_	17	compound	_	_
17	promoters	promoter	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	Taq	taq	NN	NN	_	4	compound	_	_
3	I	i	CD	CD	_	4	nummod	_	_
4	polymorphism	polymorphism	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	enabled	enable	VBD	VBD	_	6	ccomp	_	_
9	chicken	chicken	NN	NN	_	10	compound	_	_
10	IL2	il2	NN	NN	_	8	dobj	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mapped	map	VBN	VBN	_	8	xcomp	_	_
14	to	to	TO	TO	_	15	case	_	_
15	chromosome	chromosome	NN	NN	_	13	nmod	_	_
16	4	4	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	15	punct	_	_
18	linked	link	VBN	VBN	_	15	acl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	ANX5	anx5	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	with	with	IN	IN	_	23	case	_	_
23	synteny	synteny	NN	NN	_	13	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	mouse	mouse	NN	NN	_	26	compound	_	_
26	chromosome	chromosome	NN	NN	_	23	nmod	_	_
27	3	3	CD	CD	_	26	nummod	_	_
28	and	and	CC	CC	_	26	cc	_	_
29	human	human	JJ	JJ	_	30	amod	_	_
30	chromosome	chromosome	NN	NN	_	26	conj	_	_
31	4	4	CD	CD	_	30	nummod	_	_
32	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	the	the	DT	DT	_	7	det	_	_
4	first	first	JJ	JJ	_	7	amod	_	_
5	non-mammalian	non-mammalian	JJ	JJ	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	0	root	_	_
8	to	to	TO	TO	_	10	mark	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	mapped	map	VBN	VBN	_	7	acl	_	_
11	.	.	.	.	_	7	punct	_	_

1	Tobacco	tobacco	NN	NN	_	2	compound	_	_
2	smoke	smoke	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	coordinate	coordinate	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HSF	hsf	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	inhibition	inhibition	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NFkappaB	nfkappab	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
15	:	:	:	:	_	3	punct	_	_
16	effects	effect	NNS	NNS	_	3	dep	_	_
17	on	on	IN	IN	_	19	case	_	_
18	TNFalpha	tnfalpha	NN	NN	_	19	compound	_	_
19	release	release	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Tobacco	tobacco	NN	NN	_	2	compound	_	_
2	smoke	smoke	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	TS	ts	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	exposure	exposure	NN	NN	_	11	nsubj	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	risk	risk	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	disease	disease	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	macrophages	macrophage	NNS	NNS	_	21	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	healthy	healthy	JJ	JJ	_	20	amod	_	_
20	smokers	smoker	NNS	NNS	_	17	nmod	_	_
21	have	have	VBP	VBP	_	11	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	depressed	depress	VBN	VBN	_	24	amod	_	_
24	capacity	capacity	NN	NN	_	21	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	release	release	VB	VB	_	24	acl	_	_
27	cytokines	cytokine	NNS	NNS	_	26	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	including	include	VBG	VBG	_	36	case	_	_
30	tumor	tumor	NN	NN	_	36	compound	_	_
31	necrosis	necrosis	NN	NN	_	36	compound	_	_
32	factor	factor	NN	NN	_	36	compound	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	TNF	tnf	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	alpha	alpha	NN	NN	_	27	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	TS	ts	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	synthesis	synthesis	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	12	case	_	_
6	heat	heat	NN	NN	_	12	compound	_	_
7	shock	shock	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	HS	hs	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	/stress	/stress	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	4	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HSP	hsp	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	,	,	,	,	_	12	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	particular	particular	JJ	JJ	_	23	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Hsp70	hsp70	NN	NN	_	12	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	determined	determine	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	Hsp70	hsp70	NN	NN	_	5	compound	_	_
5	induction	induction	NN	NN	_	9	nsubjpass	_	_
6	by	by	IN	IN	_	7	case	_	_
7	TS	ts	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	HS	hs	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	HSF	hsf	NN	NN	_	17	appos	_	_
20	.	.	.	.	_	2	punct	_	_

1	HSF	hsf	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	inhibit	inhibit	VB	VB	_	5	xcomp	_	_
8	NFkappaB	nfkappab	NN	NN	_	7	dobj	_	_
9	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	determined	determine	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TS	ts	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	11	case	_	_
11	NFkappaB	nfkappab	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	U937	u937	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	monocytes	monocyte	NNS	NNS	_	2	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	exposed	expose	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	TS	ts	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activities	activity	NNS	NNS	_	21	nsubjpass	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	respective	respective	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	14	nmod	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	analyzed	analyze	VBN	VBN	_	9	ccomp	_	_
22	,	,	,	,	_	9	punct	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	Hsp70	hsp70	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	30	nsubjpass	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	TNFalpha	tnfalpha	NN	NN	_	28	compound	_	_
28	release	release	NN	NN	_	25	conj	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	determined	determine	VBN	VBN	_	9	conj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	parallel	parallel	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	TS	ts	NN	NN	_	2	nsubj	_	_
2	activated	activate	VBD	VBD	_	0	root	_	_
3	HSF	hsf	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	2	punct	_	_
5	which	which	WDT	WDT	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	2	ccomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	Hsp70	hsp70	NN	NN	_	10	compound	_	_
10	overexpression	overexpression	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	inhibition	inhibition	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	NFkappaB	nfkappab	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	TNFalpha	tnfalpha	NN	NN	_	19	compound	_	_
19	release	release	NN	NN	_	10	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	altered	altered	JJ	JJ	_	4	amod	_	_
3	cytokine	cytokine	NN	NN	_	4	compound	_	_
4	profile	profile	NN	NN	_	9	nsubj	_	_
5	observed	observe	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	7	case	_	_
7	smokers	smoker	NNS	NNS	_	5	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	relate	relate	VB	VB	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	HSF/Hsp70-mediated	hsf/hsp70-mediated	JJ	JJ	_	13	amod	_	_
13	inhibition	inhibition	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NFkappaB	nfkappab	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	function	function	NN	NN	_	19	nsubj	_	_
4	of	of	IN	IN	_	18	case	_	_
5	an	a	DT	DT	_	18	det	_	_
6	interleukin	interleukin	NN	NN	_	10	compound	_	_
7	2	2	CD	CD	_	10	nummod	_	_
8	receptor	receptor	NN	NN	_	10	compound	_	_
9	beta	beta	NN	NN	_	10	compound	_	_
10	chain	chain	NN	NN	_	18	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-2Rbeta	il-2rbeta	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	/	/	:	:	_	18	punct	_	_
15	IL-4Ralpha	il-4ralpha	NN	NN	_	18	compound	_	_
16	cytokine	cytokine	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	chimera	chimera	NN	NN	_	3	nmod	_	_
19	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
20	allergic	allergic	JJ	JJ	_	22	amod	_	_
21	airway	airway	NN	NN	_	22	compound	_	_
22	disease	disease	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	19	punct	_	_

1	Strength	strength	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	9	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TCR	tcr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	signaling	signaling	NN	NN	_	1	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	coreceptors	coreceptor	NNS	NNS	_	1	conj	_	_
12	,	,	,	,	_	1	punct	_	_
13	costimulation	costimulation	NN	NN	_	1	conj	_	_
14	,	,	,	,	_	1	punct	_	_
15	antigen-presenting	antigen-presenting	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	type	type	NN	NN	_	1	conj	_	_
18	,	,	,	,	_	1	punct	_	_
19	and	and	CC	CC	_	1	cc	_	_
20	cytokines	cytokine	NNS	NNS	_	1	conj	_	_
21	all	all	DT	DT	_	1	advmod	_	_
22	play	play	VBP	VBP	_	0	root	_	_
23	crucial	crucial	JJ	JJ	_	24	amod	_	_
24	roles	role	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	26	mark	_	_
26	determining	determine	VBG	VBG	_	22	advcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	efficiency	efficiency	NN	NN	_	26	dobj	_	_
29	with	with	IN	IN	_	30	case	_	_
30	which	which	WDT	WDT	_	40	nmod	_	_
31	type	type	NN	NN	_	34	compound	_	_
32	2	2	CD	CD	_	34	nummod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	lymphocytes	lymphocyte	NNS	NNS	_	40	nsubj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	Th2	th2	NN	NN	_	34	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	Tc2	tc2	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	36	punct	_	_
40	develop	develop	VBP	VBP	_	28	acl:relcl	_	_
41	from	from	IN	IN	_	43	case	_	_
42	uncommitted	uncommitted	JJ	JJ	_	43	amod	_	_
43	precursors	precursor	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	22	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	22	advcl	_	_
3	in	in	FW	FW	_	6	amod	_	_
4	vivo	vivo	FW	FW	_	3	dep	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	control	control	VBP	VBP	_	6	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	population	population	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	type	type	NN	NN	_	15	compound	_	_
13	2	2	CD	CD	_	15	nummod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	disease	disease	NN	NN	_	18	compound	_	_
18	susceptibility	susceptibility	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	22	punct	_	_
20	we	we	PRP	PRP	_	22	nsubj	_	_
21	have	have	VBP	VBP	_	22	aux	_	_
22	created	create	VBN	VBN	_	0	root	_	_
23	lines	line	NNS	NNS	_	22	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transgenic	transgenic	JJ	JJ	_	26	amod	_	_
26	mice	mouse	NNS	NNS	_	23	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	57	nmod	_	_
29	expression	expression	NN	NN	_	57	nsubjpass	_	_
30	of	of	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	chimeric	chimeric	JJ	JJ	_	34	amod	_	_
33	cytokine	cytokine	NN	NN	_	34	compound	_	_
34	receptor	receptor	NN	NN	_	29	nmod	_	_
35	(	(	-LRB-	-LRB-	_	47	punct	_	_
36	the	the	DT	DT	_	47	det	_	_
37	mouse	mouse	NN	NN	_	47	compound	_	_
38	interleukin	interleukin	NN	NN	_	47	compound	_	_
39	2	2	CD	CD	_	47	nummod	_	_
40	receptor	receptor	NN	NN	_	47	compound	_	_
41	beta	beta	NN	NN	_	47	compound	_	_
42	chain	chain	NN	NN	_	47	compound	_	_
43	-LSB-	-lsb-	-LRB-	-LRB-	_	47	punct	_	_
44	IL-2Rbeta	il-2rbeta	NN	NN	_	47	compound	_	_
45	-RSB-	-rsb-	-RRB-	-RRB-	_	47	punct	_	_
46	extracellular	extracellular	JJ	JJ	_	47	amod	_	_
47	domain	domain	NN	NN	_	34	dep	_	_
48	fused	fuse	VBN	VBN	_	47	acl	_	_
49	to	to	TO	TO	_	52	case	_	_
50	the	the	DT	DT	_	52	det	_	_
51	cytoplasmic	cytoplasmic	JJ	JJ	_	52	amod	_	_
52	tail	tail	NN	NN	_	48	nmod	_	_
53	of	of	IN	IN	_	54	case	_	_
54	IL-4Ralpha	il-4ralpha	NN	NN	_	52	nmod	_	_
55	)	)	-RRB-	-RRB-	_	47	punct	_	_
56	is	be	VBZ	VBZ	_	57	auxpass	_	_
57	targeted	target	VBN	VBN	_	23	acl:relcl	_	_
58	to	to	TO	TO	_	62	case	_	_
59	the	the	DT	DT	_	62	det	_	_
60	T	t	NN	NN	_	62	compound	_	_
61	lymphoid	lymphoid	JJ	JJ	_	62	amod	_	_
62	lineage	lineage	NN	NN	_	57	nmod	_	_
63	using	use	VBG	VBG	_	57	xcomp	_	_
64	the	the	DT	DT	_	67	det	_	_
65	proximal	proximal	JJ	JJ	_	67	amod	_	_
66	lck	lck	NN	NN	_	67	compound	_	_
67	promoter	promoter	NN	NN	_	63	dobj	_	_
68	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	chimera	chimera	NN	NN	_	3	nsubj	_	_
3	transduced	transduce	VBD	VBD	_	0	root	_	_
4	IL-4-specific	il-4-specific	JJ	JJ	_	5	amod	_	_
5	signals	signal	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	response	response	NN	NN	_	10	dep	_	_
8	to	to	TO	TO	_	10	case	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	binding	binding	NN	NN	_	3	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	dramatically	dramatically	RB	RB	_	13	advmod	_	_
13	enhanced	enhance	VBD	VBD	_	3	conj	_	_
14	type	type	NN	NN	_	16	compound	_	_
15	2	2	CD	CD	_	16	nummod	_	_
16	responses	response	NNS	NNS	_	13	dobj	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	IL-4	il-4	NN	NN	_	20	compound	_	_
19	,	,	,	,	_	20	punct	_	_
20	IL-5	il-5	NN	NN	_	16	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	immunoglobulin	immunoglobulin	NN	NN	_	25	compound	_	_
24	E	e	NN	NN	_	25	compound	_	_
25	production	production	NN	NN	_	20	conj	_	_
26	)	)	-RRB-	-RRB-	_	20	punct	_	_
27	upon	upon	IN	IN	_	31	case	_	_
28	in	in	FW	FW	_	31	amod	_	_
29	vitro	vitro	FW	FW	_	28	dep	_	_
30	TCR	tcr	NN	NN	_	31	compound	_	_
31	stimulation	stimulation	NN	NN	_	13	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	in	in	FW	FW	_	36	amod	_	_
34	vivo	vivo	FW	FW	_	33	dep	_	_
35	antigen	antigen	NN	NN	_	36	compound	_	_
36	challenge	challenge	NN	NN	_	31	conj	_	_
37	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	type	type	NN	NN	_	6	compound	_	_
4	2	2	CD	CD	_	6	nummod	_	_
5	effector	effector	NN	NN	_	6	compound	_	_
6	function	function	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	augmented	augment	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	IL-4	il-4	NN	NN	_	11	compound	_	_
11	signals	signal	NNS	NNS	_	8	nmod	_	_
12	transduced	transduce	VBN	VBN	_	11	acl	_	_
13	through	through	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	chimeric	chimeric	JJ	JJ	_	16	amod	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	expressed	express	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell-specific	cell-specific	JJ	JJ	_	22	amod	_	_
22	manner	manner	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	influence	influence	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	sufficient	sufficient	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	6	case	_	_
6	establishment	establishment	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	antigen-induced	antigen-induced	JJ	JJ	_	11	amod	_	_
9	allergic	allergic	JJ	JJ	_	11	amod	_	_
10	airway	airway	NN	NN	_	11	compound	_	_
11	hyperresponsiveness	hyperresponsiveness	NN	NN	_	6	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	disease-resistant	disease-resistant	JJ	JJ	_	15	amod	_	_
15	background	background	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	C57BL/6	c57bl/6	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	4	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	2	amod	_	_
2	study	study	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-fos-positive	c-fos-positive	JJ	JJ	_	5	amod	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	infiltrated	infiltrate	VBN	VBN	_	5	acl	_	_
7	into	into	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	squamous	squamous	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	carcinomas	carcinoma	NNS	NNS	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	head	head	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	neck	neck	NN	NN	_	14	conj	_	_
17	during	during	IN	IN	_	19	case	_	_
18	radiation	radiation	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	6	nmod	_	_
20	and	and	CC	CC	_	2	cc	_	_
21	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
22	clinical	clinical	JJ	JJ	_	23	amod	_	_
23	significance	significance	NN	NN	_	2	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	C-fos	c-fos	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	one	one	CD	CD	_	4	xcomp	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	immediate	immediate	JJ	JJ	_	12	amod	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	signal	signal	NN	NN	_	16	compound	_	_
15	transduction	transduction	NN	NN	_	16	compound	_	_
16	systems	system	NNS	NNS	_	12	nmod	_	_
17	after	after	IN	IN	_	19	case	_	_
18	many	many	JJ	JJ	_	19	amod	_	_
19	kinds	kind	NNS	NNS	_	7	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	stresses	stress	NNS	NNS	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	including	include	VBG	VBG	_	25	case	_	_
24	ionizing	ionize	VBG	VBG	_	25	amod	_	_
25	radiation	radiation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Changes	change	NNS	NNS	_	16	nsubjpass	_	_
2	in	in	IN	IN	_	4	case	_	_
3	c-fos	c-fos	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	induced	induce	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	8	case	_	_
7	radiation	radiation	NN	NN	_	8	compound	_	_
8	therapy	therapy	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	tumor	tumor	NN	NN	_	11	compound	_	_
11	tissues	tissue	NNS	NNS	_	4	nmod	_	_
12	have	have	VBP	VBP	_	16	aux	_	_
13	not	not	RB	RB	_	16	neg	_	_
14	yet	yet	RB	RB	_	16	advmod	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	reported	report	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	attempted	attempt	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	determine	determine	VB	VB	_	7	ccomp	_	_
10	whether	whether	IN	IN	_	14	mark	_	_
11	c-fos	c-fos	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	9	ccomp	_	_
15	by	by	IN	IN	_	16	case	_	_
16	radiotherapy	radiotherapy	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	human	human	JJ	JJ	_	21	amod	_	_
19	squamous	squamous	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	carcinomas	carcinoma	NNS	NNS	_	14	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	head	head	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	neck	neck	NN	NN	_	24	conj	_	_
27	and	and	CC	CC	_	9	cc	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	establish	establish	VB	VB	_	9	conj	_	_
30	a	a	DT	DT	_	32	det	_	_
31	possible	possible	JJ	JJ	_	32	amod	_	_
32	correlation	correlation	NN	NN	_	29	dobj	_	_
33	between	between	IN	IN	_	35	case	_	_
34	c-fos	c-fos	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	therapeutic	therapeutic	JJ	JJ	_	39	amod	_	_
39	effects	effect	NNS	NNS	_	35	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	radiation	radiation	NN	NN	_	42	compound	_	_
42	therapy	therapy	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Twenty-seven	twenty-seven	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	16	nsubjpass	_	_
3	with	with	IN	IN	_	4	case	_	_
4	tumors	tumor	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	oral	oral	JJ	JJ	_	8	amod	_	_
8	cavity	cavity	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	oropharynx	oropharynx	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	maxillary	maxillary	JJ	JJ	_	14	amod	_	_
14	sinus	sinus	NN	NN	_	8	conj	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	all	all	DT	DT	_	22	nsubjpass	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	confirmed	confirm	VBN	VBN	_	16	ccomp	_	_
23	as	as	IN	IN	_	26	case	_	_
24	squamous	squamous	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	carcinomas	carcinoma	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	After	after	IN	IN	_	2	mark	_	_
2	obtaining	obtain	VBG	VBG	_	11	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	patients	patient	NNS	NNS	_	7	nmod:poss	_	_
5	'	'	POS	POS	_	4	case	_	_
6	informed	inform	VBN	VBN	_	7	amod	_	_
7	consent	consent	NN	NN	_	2	dobj	_	_
8	,	,	,	,	_	11	punct	_	_
9	biopsies	biopsy	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	performed	perform	VBN	VBN	_	0	root	_	_
12	before	before	IN	IN	_	13	case	_	_
13	treatment	treatment	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	at	at	IN	IN	_	16	case	_	_
16	doses	dose	NNS	NNS	_	13	conj	_	_
17	of	of	IN	IN	_	24	case	_	_
18	4	4	CD	CD	_	20	nummod	_	_
19	,	,	,	,	_	20	punct	_	_
20	10	10	CD	CD	_	24	nummod	_	_
21	,	,	,	,	_	20	punct	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	20	20	CD	CD	_	20	conj	_	_
24	Gy	gy	NN	NN	_	16	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	radiotherapy	radiotherapy	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	11	punct	_	_
28	and	and	CC	CC	_	11	cc	_	_
29	the	the	DT	DT	_	30	det	_	_
30	specimens	specimen	NNS	NNS	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	preserved	preserve	VBN	VBN	_	11	conj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	liquid	liquid	JJ	JJ	_	35	amod	_	_
35	nitrogen	nitrogen	NN	NN	_	32	nmod	_	_
36	for	for	IN	IN	_	38	case	_	_
37	further	further	JJ	JJ	_	38	amod	_	_
38	examination	examination	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	Serial	serial	JJ	JJ	_	2	amod	_	_
2	sectioning	sectioning	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	6	6	CD	CD	_	5	nummod	_	_
5	micrometer	micrometer	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	performed	perform	VBN	VBN	_	0	root	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	cryostat	cryostat	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	samples	sample	NNS	NNS	_	16	nsubjpass	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	immunohistochemically	immunohistochemically	RB	RB	_	16	advmod	_	_
16	stained	stain	VBN	VBN	_	7	conj	_	_
17	using	use	VBG	VBG	_	16	xcomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	streptoavidin-biotin	streptoavidin-biotin	JJ	JJ	_	20	dep	_	_
20	peroxidase	peroxidase	NN	NN	_	21	amod	_	_
21	method	method	NN	NN	_	17	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	a	a	DT	DT	_	25	det	_	_
24	monoclonal	monoclonal	JJ	JJ	_	25	amod	_	_
25	antibody	antibody	NN	NN	_	21	conj	_	_
26	against	against	IN	IN	_	27	case	_	_
27	c-fos	c-fos	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Three	three	CD	CD	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	27	27	CD	CD	_	5	nummod	_	_
5	patients	patient	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	squamous	squamous	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	carcinoma	carcinoma	NN	NN	_	5	nmod	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	slight	slight	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	c-fos	c-fos	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
17	tumor	tumor	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	before	before	IN	IN	_	27	nmod	_	_
20	and/or	and/or	CC	CC	_	19	cc	_	_
21	at	at	IN	IN	_	25	case	_	_
22	4	4	CD	CD	_	25	nummod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	10	10	CD	CD	_	22	conj	_	_
25	Gy	gy	NN	NN	_	19	conj	_	_
26	of	of	IN	IN	_	25	acl	_	_
27	radiotherapy	radiotherapy	NN	NN	_	10	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	tumors	tumor	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	radiosensitivity	radiosensitivity	NN	NN	_	3	dobj	_	_
6	.	.	.	.	_	3	punct	_	_

1	Concerning	concern	VBG	VBG	_	3	case	_	_
2	tumor-infiltrating	tumor-infiltrating	JJ	JJ	_	3	amod	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	38	nmod	_	_
4	,	,	,	,	_	38	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	rate	rate	NN	NN	_	38	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	moderate	moderate	JJ	JJ	_	11	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	remarkable	remarkable	JJ	JJ	_	8	conj	_	_
11	grades	grade	NNS	NNS	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	c-fos-positive	c-fos-positive	JJ	JJ	_	14	amod	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	before	before	IN	IN	_	16	case	_	_
16	radiotherapy	radiotherapy	NN	NN	_	6	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	at	at	IN	IN	_	20	case	_	_
19	radiation	radiation	NN	NN	_	20	compound	_	_
20	doses	dose	NNS	NNS	_	16	conj	_	_
21	of	of	IN	IN	_	28	case	_	_
22	4	4	CD	CD	_	24	nummod	_	_
23	,	,	,	,	_	24	punct	_	_
24	10	10	CD	CD	_	28	nummod	_	_
25	,	,	,	,	_	24	punct	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	20	20	CD	CD	_	24	conj	_	_
28	Gy	gy	NN	NN	_	20	nmod	_	_
29	was	be	VBD	VBD	_	38	cop	_	_
30	8.0	8.0	CD	CD	_	34	nummod	_	_
31	,	,	,	,	_	34	punct	_	_
32	29.2	29.2	CD	CD	_	34	nummod	_	_
33	,	,	,	,	_	34	punct	_	_
34	4.8	4.8	CD	CD	_	38	nummod	_	_
35	,	,	,	,	_	34	punct	_	_
36	and	and	CC	CC	_	34	cc	_	_
37	0	0	CD	CD	_	34	conj	_	_
38	%	%	NN	NN	_	0	root	_	_
39	,	,	,	,	_	38	punct	_	_
40	respectively	respectively	RB	RB	_	38	advmod	_	_
41	.	.	.	.	_	38	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	relationship	relationship	NN	NN	_	19	nsubjpass	_	_
3	between	between	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	immunohistochemical	immunohistochemical	JJ	JJ	_	6	amod	_	_
6	findings	finding	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	10	det	_	_
9	antitumor	antitumor	NN	NN	_	10	compound	_	_
10	effect	effect	NN	NN	_	6	conj	_	_
11	at	at	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	radiation	radiation	NN	NN	_	14	compound	_	_
14	dose	dose	NN	NN	_	6	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	20	20	CD	CD	_	17	nummod	_	_
17	Gy	gy	NN	NN	_	14	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	examined	examine	VBN	VBN	_	0	root	_	_
20	on	on	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	corresponding	corresponding	JJ	JJ	_	26	amod	_	_
23	H	h	NN	NN	_	26	amod	_	_
24	&amp;	&amp;	CC	CC	_	23	cc	_	_
25	E-stained	e-stained	JJ	JJ	_	23	conj	_	_
26	sections	section	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	23	nmod	_	_
3	whose	whose	WP$	WP$	_	4	nmod:poss	_	_
4	infiltration	infiltration	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	c-fos-positive	c-fos-positive	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
8	into	into	IN	IN	_	10	case	_	_
9	tumor	tumor	NN	NN	_	10	compound	_	_
10	tissues	tissue	NNS	NNS	_	4	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	moderate	moderate	JJ	JJ	_	2	acl:relcl	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	remarkable	remarkable	JJ	JJ	_	12	conj	_	_
15	at	at	IN	IN	_	17	case	_	_
16	4	4	CD	CD	_	17	nummod	_	_
17	Gy	gy	NN	NN	_	12	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	radiotherapy	radiotherapy	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	23	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	tumors	tumor	NNS	NNS	_	23	nsubj	_	_
23	responded	respond	VBD	VBD	_	0	root	_	_
24	significantly	significantly	RB	RB	_	25	advmod	_	_
25	well	well	RB	RB	_	23	advmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	radiation	radiation	NN	NN	_	28	compound	_	_
28	therapy	therapy	NN	NN	_	23	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	P	p	NN	NN	_	31	dep	_	_
31	&lt;	&lt;	JJR	JJR	_	23	parataxis	_	_
32	0.025	0.025	CD	CD	_	31	nummod	_	_
33	,	,	,	,	_	31	punct	_	_
34	chi2	chi2	NN	NN	_	35	compound	_	_
35	test	test	NN	NN	_	31	dep	_	_
36	)	)	-RRB-	-RRB-	_	31	punct	_	_
37	,	,	,	,	_	23	punct	_	_
38	and	and	CC	CC	_	23	cc	_	_
39	the	the	DT	DT	_	40	det	_	_
40	patients	patient	NNS	NNS	_	41	nsubj	_	_
41	took	take	VBD	VBD	_	23	conj	_	_
42	a	a	DT	DT	_	46	det	_	_
43	significantly	significantly	RB	RB	_	44	advmod	_	_
44	favorable	favorable	JJ	JJ	_	46	amod	_	_
45	clinical	clinical	JJ	JJ	_	46	amod	_	_
46	course	course	NN	NN	_	41	dobj	_	_
47	(	(	-LRB-	-LRB-	_	49	punct	_	_
48	P	p	NN	NN	_	49	dep	_	_
49	&lt;	&lt;	JJR	JJR	_	41	parataxis	_	_
50	0.05	0.05	CD	CD	_	49	nummod	_	_
51	,	,	,	,	_	49	punct	_	_
52	chi2	chi2	NN	NN	_	53	compound	_	_
53	test	test	NN	NN	_	49	dep	_	_
54	)	)	-RRB-	-RRB-	_	49	punct	_	_
55	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	sample	sample	NN	NN	_	13	nmod	_	_
4	from	from	IN	IN	_	5	case	_	_
5	one	one	CD	CD	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	c-fos-positive	c-fos-positive	JJ	JJ	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	13	nsubjpass	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	identified	identify	VBN	VBN	_	0	root	_	_
14	as	as	IN	IN	_	16	case	_	_
15	CD4	cd4	NN	NN	_	16	nmod:npmod	_	_
16	positive	positive	JJ	JJ	_	13	advcl	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CD8	cd8	NN	NN	_	19	nmod:npmod	_	_
19	negative	negative	JJ	JJ	_	16	conj	_	_
20	.	.	.	.	_	13	punct	_	_

1	Therefore	therefore	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	radiosensitivity	radiosensitivity	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	squamous	squamous	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	carcinomas	carcinoma	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	our	we	PRP$	PRP$	_	12	nmod:poss	_	_
12	samples	sample	NNS	NNS	_	9	nmod	_	_
13	could	could	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	explained	explain	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	an	a	DT	DT	_	18	det	_	_
18	overexpression	overexpression	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	c-fos	c-fos	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	tumor-infiltrating	tumor-infiltrating	JJ	JJ	_	24	amod	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
25	induced	induce	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	small	small	JJ	JJ	_	28	amod	_	_
28	doses	dose	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	radiation	radiation	NN	NN	_	31	compound	_	_
31	therapy	therapy	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	15	punct	_	_
33	and	and	CC	CC	_	15	cc	_	_
34	these	these	DT	DT	_	36	det	_	_
35	activated	activate	VBN	VBN	_	36	amod	_	_
36	lymphocytes	lymphocyte	NNS	NNS	_	37	nsubj	_	_
37	exerted	exert	VBD	VBD	_	15	conj	_	_
38	a	a	DT	DT	_	40	det	_	_
39	cytotoxic	cytotoxic	JJ	JJ	_	40	amod	_	_
40	effect	effect	NN	NN	_	37	dobj	_	_
41	against	against	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	cancer	cancer	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	15	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	beta-casein	beta-casein	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	cytokines	cytokine	NNS	NNS	_	2	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	cross-talk	cross-talk	NN	NN	_	2	dep	_	_
11	between	between	IN	IN	_	12	case	_	_
12	STAT5	stat5	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	signaling	signal	VBG	VBG	_	16	amod	_	_
16	molecules	molecule	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	beta-casein	beta-casein	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	7	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	7	aux	_	_
5	been	be	VBN	VBN	_	7	auxpass	_	_
6	widely	widely	RB	RB	_	7	advmod	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	monitor	monitor	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	STAT	stat	NN	NN	_	16	compound	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	signal	signal	NN	NN	_	16	compound	_	_
16	transducer	transducer	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activator	activator	NN	NN	_	20	compound	_	_
19	of	of	IN	IN	_	20	amod	_	_
20	transcription	transcription	NN	NN	_	16	conj	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	5	5	CD	CD	_	20	nummod	_	_
23	since	since	IN	IN	_	27	mark	_	_
24	STAT5	stat5	NN	NN	_	27	nsubjpass	_	_
25	was	be	VBD	VBD	_	27	auxpass	_	_
26	originally	originally	RB	RB	_	27	advmod	_	_
27	found	find	VBN	VBN	_	7	advcl	_	_
28	as	as	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	mediator	mediator	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	PRL-inducible	prl-inducible	JJ	JJ	_	34	amod	_	_
33	beta-casein	beta-casein	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	only	only	RB	RB	_	11	cc:preconj	_	_
5	is	be	VBZ	VBZ	_	11	auxpass	_	_
6	expression	expression	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	beta-casein	beta-casein	NN	NN	_	10	compound	_	_
10	gene	gene	NN	NN	_	6	nmod	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	STAT5	stat5	NN	NN	_	11	nmod	_	_
14	but	but	CC	CC	_	11	cc	_	_
15	it	it	PRP	PRP	_	18	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	affected	affect	VBN	VBN	_	11	conj	_	_
19	by	by	IN	IN	_	21	case	_	_
20	other	other	JJ	JJ	_	21	amod	_	_
21	molecules	molecule	NNS	NNS	_	18	nmod	_	_
22	such	such	JJ	JJ	_	24	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Ras	ras	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	beta-casein	beta-casein	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	beta-casein	beta-casein	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	3	ccomp	_	_
10	in	in	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	cytotoxic	cytotoxic	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	CTLL-2	ctll-2	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	15	punct	_	_
19	in	in	IN	IN	_	22	case	_	_
20	response	response	NN	NN	_	22	dep	_	_
21	to	to	TO	TO	_	22	case	_	_
22	interleukin-2	interleukin-2	NN	NN	_	9	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	IL-2	il-2	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	22	punct	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	activates	activate	VBZ	VBZ	_	22	acl:relcl	_	_
29	STAT5	stat5	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	While	while	IN	IN	_	5	mark	_	_
2	IL-4	il-4	NN	NN	_	5	nsubj	_	_
3	does	do	VBZ	VBZ	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	activate	activate	VB	VB	_	9	advcl	_	_
6	STAT5	stat5	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	9	punct	_	_
8	it	it	PRP	PRP	_	9	nsubj	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	expression	expression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	STAT5-regulated	stat5-regulated	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	CTLL-2	ctll-2	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	i.e.	i.e.	FW	FW	_	18	dep	_	_
18	beta-casein	beta-casein	NN	NN	_	13	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	23	det	_	_
21	cytokine-inducible	cytokine-inducible	JJ	JJ	_	23	amod	_	_
22	SH2-containing	sh2-containing	JJ	JJ	_	23	amod	_	_
23	protein	protein	NN	NN	_	18	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CIS	cis	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	18	punct	_	_
28	and	and	CC	CC	_	18	cc	_	_
29	oncostatin	oncostatin	NN	NN	_	30	compound	_	_
30	M	m	NN	NN	_	18	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	OSM	osm	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	9	punct	_	_
35	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
36	that	that	IN	IN	_	41	mark	_	_
37	STAT6	stat6	NN	NN	_	41	nsubj	_	_
38	activated	activate	VBN	VBN	_	37	acl	_	_
39	by	by	IN	IN	_	40	case	_	_
40	IL-4	il-4	NN	NN	_	38	nmod	_	_
41	substitutes	substitute	VBZ	VBZ	_	35	ccomp	_	_
42	for	for	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	function	function	NN	NN	_	41	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	STAT5	stat5	NN	NN	_	44	nmod	_	_
47	in	in	IN	IN	_	49	case	_	_
48	T	t	NN	NN	_	49	compound	_	_
49	cells	cell	NNS	NNS	_	44	nmod	_	_
50	.	.	.	.	_	9	punct	_	_

1	IL-2-induced	il-2-induced	JJ	JJ	_	3	amod	_	_
2	beta-casein	beta-casein	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	enhanced	enhance	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	dexamethasone	dexamethasone	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	this	this	DT	DT	_	12	det	_	_
11	synergistic	synergistic	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	15	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	Dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	requires	require	VBZ	VBZ	_	5	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	sequence	sequence	NN	NN	_	15	dobj	_	_
18	between	between	IN	IN	_	19	case	_	_
19	-155	-155	CD	CD	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	-193	-193	CD	CD	_	19	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	beta-casein	beta-casein	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Coincidentally	coincidentally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	deletion	deletion	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	region	region	NN	NN	_	4	nmod	_	_
8	enhanced	enhance	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2-induced	il-2-induced	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	beta-casein	beta-casein	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Expression	expression	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	an	a	DT	DT	_	5	det	_	_
4	active	active	JJ	JJ	_	5	amod	_	_
5	form	form	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Ras	ras	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	Ras(G12V)	ras(g12v)	NN	NN	_	5	appos	_	_
10	,	,	,	,	_	5	punct	_	_
11	suppressed	suppress	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	18	det	_	_
13	IL-2-induced	il-2-induced	JJ	JJ	_	18	amod	_	_
14	beta-casein	beta-casein	NN	NN	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	OSM	osm	NN	NN	_	14	conj	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	11	dobj	_	_
19	,	,	,	,	_	11	punct	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	negative	negative	JJ	JJ	_	23	amod	_	_
23	effect	effect	NN	NN	_	27	nsubjpass	_	_
24	of	of	IN	IN	_	25	case	_	_
25	Ras	ras	NN	NN	_	23	nmod	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	mediated	mediate	VBN	VBN	_	11	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	region	region	NN	NN	_	27	nmod	_	_
31	between	between	IN	IN	_	32	case	_	_
32	-105	-105	CD	CD	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	-193	-193	CD	CD	_	32	conj	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	beta-casein	beta-casein	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	30	nmod	_	_
39	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	apparent	apparent	JJ	JJ	_	3	amod	_	_
3	contradiction	contradiction	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	expression	expression	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	dominant	dominant	JJ	JJ	_	10	amod	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	form	form	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Ras	ras	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	RasN17	rasn17	NN	NN	_	10	appos	_	_
15	,	,	,	,	_	10	punct	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	inhibited	inhibit	VBD	VBD	_	0	root	_	_
18	IL-2-induced	il-2-induced	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	promoter	promoter	NN	NN	_	19	nmod	_	_
23	containing	contain	VBG	VBG	_	22	acl	_	_
24	the	the	DT	DT	_	28	det	_	_
25	minimal	minimal	JJ	JJ	_	28	amod	_	_
26	beta-casein	beta-casein	NN	NN	_	28	compound	_	_
27	STAT5	stat5	NN	NN	_	28	compound	_	_
28	element	element	NN	NN	_	23	dobj	_	_
29	as	as	RB	RB	_	22	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	the	the	DT	DT	_	33	det	_	_
33	promoters	promoter	NNS	NNS	_	22	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	CIS	cis	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	OSM	osm	NN	NN	_	35	conj	_	_
38	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	Ras(G12V)	ras(g12v)	NN	NN	_	5	nsubj	_	_
5	complemented	complement	VBD	VBD	_	0	root	_	_
6	signaling	signaling	NN	NN	_	5	dobj	_	_
7	by	by	IN	IN	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	erythropoietin	erythropoietin	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	mutant	mutant	NN	NN	_	5	nmod	_	_
12	defective	defective	JJ	JJ	_	11	amod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	Ras	ras	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	augmented	augment	VBD	VBD	_	5	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	beta-casein	beta-casein	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	19	nmod	_	_
24	by	by	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	mutant	mutant	JJ	JJ	_	29	amod	_	_
27	erythropoietin	erythropoietin	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	signaling	signaling	NN	NN	_	17	nmod	_	_
30	,	,	,	,	_	5	punct	_	_
31	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
32	a	a	DT	DT	_	34	det	_	_
33	possible	possible	JJ	JJ	_	34	amod	_	_
34	role	role	NN	NN	_	31	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	Ras	ras	NN	NN	_	34	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	Stat5-mediated	stat5-mediated	JJ	JJ	_	40	amod	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	collectively	collectively	RB	RB	_	4	advmod	_	_
4	reveal	reveal	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	complex	complex	JJ	JJ	_	7	amod	_	_
7	interaction	interaction	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	STAT5	stat5	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	illustrate	illustrate	VBP	VBP	_	4	conj	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	regulation	regulation	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	requires	require	VBZ	VBZ	_	15	ccomp	_	_
22	integration	integration	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	opposing	opposing	JJ	JJ	_	25	amod	_	_
25	signals	signal	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Transcription	transcription	NN	NN	_	4	compound	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	regulation	regulation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	renal	renal	JJ	JJ	_	7	amod	_	_
7	fibrosis	fibrosis	NN	NN	_	4	nmod	_	_
8	during	during	IN	IN	_	10	case	_	_
9	ureteral	ureteral	JJ	JJ	_	10	amod	_	_
10	obstruction	obstruction	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Irrespective	irrespective	RB	RB	_	4	advmod	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	etiology	etiology	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	many	many	JJ	JJ	_	8	amod	_	_
7	kidney	kidney	NN	NN	_	8	compound	_	_
8	diseases	disease	NNS	NNS	_	9	nsubj	_	_
9	result	result	VBP	VBP	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	inflammation	inflammation	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	fibrosis	fibrosis	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	tubulointerstitium	tubulointerstitium	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	subsequent	subsequent	JJ	JJ	_	21	amod	_	_
21	loss	loss	NN	NN	_	9	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	renal	renal	JJ	JJ	_	24	amod	_	_
24	function	function	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	initiate	initiate	VB	VB	_	17	dep	_	_
3	any	any	DT	DT	_	5	det	_	_
4	disease	disease	NN	NN	_	5	compound	_	_
5	process	process	NN	NN	_	2	dobj	_	_
6	or	or	CC	CC	_	2	cc	_	_
7	for	for	IN	IN	_	12	mark	_	_
8	any	any	DT	DT	_	10	det	_	_
9	disease	disease	NN	NN	_	10	compound	_	_
10	process	process	NN	NN	_	12	nsubj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	progress	progress	VB	VB	_	2	conj	_	_
13	,	,	,	,	_	17	punct	_	_
14	there	there	EX	EX	_	17	expl	_	_
15	must	must	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	changes	change	NNS	NNS	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	transcription	transcription	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	genes	gene	NNS	NNS	_	20	nmod	_	_
23	within	within	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	affected	affect	VBN	VBN	_	26	amod	_	_
26	tissue	tissue	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
3	factor-kappa	factor-kappa	NN	NN	_	8	compound	_	_
4	B	b	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	family	family	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	8	nmod	_	_
12	regulates	regulate	VBZ	VBZ	_	0	root	_	_
13	genes	gene	NNS	NNS	_	12	dobj	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	inflammation	inflammation	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	proliferation	proliferation	NN	NN	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	differentiation	differentiation	NN	NN	_	16	conj	_	_
24	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	discusses	discuss	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
6	transcription	transcription	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	family	family	NN	NN	_	3	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	general	general	JJ	JJ	_	8	acl	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	association	association	NN	NN	_	8	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	cellular/molecular	cellular/molecular	JJ	JJ	_	19	amod	_	_
19	events	event	NNS	NNS	_	13	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	renal	renal	JJ	JJ	_	22	amod	_	_
22	inflammation	inflammation	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	fibrosis	fibrosis	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	TAL1	tal1	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	LIM-only	lim-only	JJ	JJ	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	1	conj	_	_
5	synergistically	synergistically	RB	RB	_	6	advmod	_	_
6	induce	induce	VBP	VBP	_	0	root	_	_
7	retinaldehyde	retinaldehyde	NN	NN	_	10	compound	_	_
8	dehydrogenase	dehydrogenase	NN	NN	_	10	compound	_	_
9	2	2	CD	CD	_	10	nummod	_	_
10	expression	expression	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	T-cell	t-cell	NN	NN	_	15	compound	_	_
13	acute	acute	JJ	JJ	_	15	amod	_	_
14	lymphoblastic	lymphoblastic	JJ	JJ	_	15	amod	_	_
15	leukemia	leukemia	NN	NN	_	6	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	acting	act	VBG	VBG	_	6	advcl	_	_
18	as	as	IN	IN	_	19	case	_	_
19	cofactors	cofactor	NNS	NNS	_	17	nmod	_	_
20	for	for	IN	IN	_	21	case	_	_
21	GATA3	gata3	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Previously	previously	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	TAL1	tal1	NN	NN	_	18	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	12	det	_	_
10	LIM-only	lim-only	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LMO	lmo	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	are	be	VBP	VBP	_	18	auxpass	_	_
17	regularly	regularly	RB	RB	_	18	advmod	_	_
18	coactivated	coactivate	VBN	VBN	_	5	ccomp	_	_
19	in	in	IN	IN	_	23	case	_	_
20	T-cell	t-cell	NN	NN	_	23	compound	_	_
21	acute	acute	JJ	JJ	_	23	amod	_	_
22	lymphoblastic	lymphoblastic	JJ	JJ	_	23	amod	_	_
23	leukemia	leukemia	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	T-ALL	t-all	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	likely	likely	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	relate	relate	VB	VB	_	4	xcomp	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	findings	finding	NNS	NNS	_	6	nmod	_	_
10	that	that	IN	IN	_	16	mark	_	_
11	TAL1	tal1	NN	NN	_	16	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	LMO	lmo	NN	NN	_	11	conj	_	_
14	are	be	VBP	VBP	_	16	cop	_	_
15	highly	highly	RB	RB	_	16	advmod	_	_
16	synergistic	synergistic	JJ	JJ	_	9	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	tumorigenesis	tumorigenesis	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	double-transgenic	double-transgenic	JJ	JJ	_	22	amod	_	_
22	mice	mouse	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	20	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	functional	functional	JJ	JJ	_	8	amod	_	_
8	synergy	synergy	NN	NN	_	5	nmod	_	_
9	between	between	IN	IN	_	10	case	_	_
10	TAL1	tal1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	LMO	lmo	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	tumorigenesis	tumorigenesis	NN	NN	_	5	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	regulation	regulation	NN	NN	_	14	conj	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	tried	try	VBD	VBD	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	identify	identify	VB	VB	_	20	xcomp	_	_
23	downstream	downstream	JJ	JJ	_	25	amod	_	_
24	target	target	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	22	dobj	_	_
26	regulated	regulate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	TAL1	tal1	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	LMO	lmo	NN	NN	_	28	conj	_	_
31	by	by	IN	IN	_	35	case	_	_
32	a	a	DT	DT	_	35	det	_	_
33	subtractive	subtractive	JJ	JJ	_	35	amod	_	_
34	PCR	pcr	NN	NN	_	35	compound	_	_
35	method	method	NN	NN	_	26	nmod	_	_
36	.	.	.	.	_	20	punct	_	_

1	One	one	CD	CD	_	18	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	isolated	isolate	VBN	VBN	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	that	that	DT	DT	_	1	appos	_	_
8	for	for	IN	IN	_	10	case	_	_
9	retinaldehyde	retinaldehyde	NN	NN	_	10	compound	_	_
10	dehydrogenase	dehydrogenase	NN	NN	_	7	nmod	_	_
11	2	2	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	RALDH2	raldh2	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	1	punct	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	regularly	regularly	RB	RB	_	18	advmod	_	_
18	expressed	express	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	most	most	JJS	JJS	_	18	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	T-ALL	t-all	NN	NN	_	25	compound	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	20	nmod	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	coexpressed	coexpress	VBD	VBD	_	25	acl:relcl	_	_
28	TAL1	tal1	NN	NN	_	27	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	LMO	lmo	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	18	punct	_	_

1	Exogenously	exogenously	RB	RB	_	2	advmod	_	_
2	transfected	transfect	VBN	VBN	_	3	amod	_	_
3	TAL1	tal1	NN	NN	_	12	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	LMO	lmo	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	3	cc	_	_
9	either	either	DT	DT	_	3	conj	_	_
10	alone	alone	RB	RB	_	9	advmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	RALDH2	raldh2	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	T-ALL	t-all	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	HPB-ALL	hpb-all	NN	NN	_	19	appos	_	_
22	,	,	,	,	_	19	punct	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	expressing	express	VBG	VBG	_	12	xcomp	_	_
25	endogeneous	endogeneous	JJ	JJ	_	26	amod	_	_
26	TAL1	tal1	NN	NN	_	24	dobj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	LMO	lmo	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	RALDH2	raldh2	NN	NN	_	3	compound	_	_
3	transcripts	transcript	NNS	NNS	_	11	nsubjpass	_	_
4	in	in	IN	IN	_	5	case	_	_
5	T-ALL	t-all	NN	NN	_	3	nmod	_	_
6	were	be	VBD	VBD	_	11	auxpass	_	_
7	,	,	,	,	_	11	punct	_	_
8	however	however	RB	RB	_	11	advmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	mostly	mostly	RB	RB	_	11	advmod	_	_
11	initiated	initiate	VBN	VBN	_	0	root	_	_
12	within	within	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	second	second	JJ	JJ	_	15	amod	_	_
15	intron	intron	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	GATA	gata	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	17	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	cryptic	cryptic	JJ	JJ	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	second	second	JJ	JJ	_	15	amod	_	_
15	intron	intron	NN	NN	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	essential	essential	JJ	JJ	_	3	ccomp	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	sufficient	sufficient	JJ	JJ	_	17	conj	_	_
20	for	for	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	TAL1-	tal1-	NN	NN	_	26	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	LMO-dependent	lmo-dependent	JJ	JJ	_	22	conj	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	17	nmod	_	_
27	,	,	,	,	_	3	punct	_	_
28	and	and	CC	CC	_	3	cc	_	_
29	GATA3	gata3	NN	NN	_	30	nsubj	_	_
30	binds	bind	VBZ	VBZ	_	3	conj	_	_
31	to	to	TO	TO	_	33	case	_	_
32	this	this	DT	DT	_	33	det	_	_
33	site	site	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	forced	force	VBN	VBN	_	5	amod	_	_
5	expression	expression	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GATA3	gata3	NN	NN	_	5	nmod	_	_
8	potentiated	potentiate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	RALDH2	raldh2	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	TAL1	tal1	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	LMO	lmo	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	these	these	DT	DT	_	21	det	_	_
20	three	three	CD	CD	_	21	nummod	_	_
21	factors	factor	NNS	NNS	_	22	nsubj	_	_
22	formed	form	VBD	VBD	_	8	conj	_	_
23	a	a	DT	DT	_	24	det	_	_
24	complex	complex	NN	NN	_	22	dobj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	22	advmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	TAL1	tal1	NN	NN	_	5	compound	_	_
5	mutant	mutant	NN	NN	_	11	nsubj	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	binding	bind	VBG	VBG	_	5	acl	_	_
8	to	to	TO	TO	_	9	case	_	_
9	DNA	dna	NN	NN	_	7	nmod	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	activated	activate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	RALDH2	raldh2	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	dep	_	_
18	presence	presence	NN	NN	_	20	dep	_	_
19	of	of	IN	IN	_	20	case	_	_
20	LMO	lmo	NN	NN	_	11	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	GATA3	gata3	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	11	punct	_	_

1	Collectively	collectively	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	RALDH2	raldh2	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	5	dobj	_	_
9	as	as	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	first	first	JJ	JJ	_	12	amod	_	_
12	example	example	NN	NN	_	5	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	direct	direct	JJ	JJ	_	17	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
16	target	target	NN	NN	_	17	compound	_	_
17	genes	gene	NNS	NNS	_	12	nmod	_	_
18	regulated	regulate	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	TAL1	tal1	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	LMO	lmo	NN	NN	_	20	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	T-ALL	t-all	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	TAL1	tal1	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	LMO	lmo	NN	NN	_	5	conj	_	_
8	act	act	VBP	VBP	_	0	root	_	_
9	as	as	IN	IN	_	10	case	_	_
10	cofactors	cofactor	NNS	NNS	_	8	nmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	GATA3	gata3	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	activate	activate	VB	VB	_	8	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	transcription	transcription	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	RALDH2	raldh2	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	oncogenic	oncogenic	JJ	JJ	_	5	amod	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	HOX11	hox11	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	0	root	_	_
7	Aldh1	aldh1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	NIH	nih	NN	NN	_	12	compound	_	_
11	3T3	3t3	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	but	but	CC	CC	_	6	cc	_	_
14	represses	repress	VBZ	VBZ	_	6	conj	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	mouse	mouse	NN	NN	_	20	compound	_	_
19	spleen	spleen	NN	NN	_	20	compound	_	_
20	development	development	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Hox11	hox11	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	homeobox	homeobox	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	0	root	_	_
6	essential	essential	JJ	JJ	_	5	amod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	spleen	spleen	NN	NN	_	9	compound	_	_
9	formation	formation	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	mice	mouse	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	since	since	IN	IN	_	22	mark	_	_
14	atrophy	atrophy	NN	NN	_	22	nsubj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	anlage	anlage	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	developing	develop	VBG	VBG	_	21	amod	_	_
21	spleen	spleen	NN	NN	_	17	nmod	_	_
22	occurs	occur	VBZ	VBZ	_	5	advcl	_	_
23	in	in	IN	IN	_	26	case	_	_
24	early	early	JJ	JJ	_	26	amod	_	_
25	embryonic	embryonic	JJ	JJ	_	26	amod	_	_
26	development	development	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	Hox11	hox11	NN	NN	_	30	compound	_	_
29	null	null	JJ	JJ	_	30	amod	_	_
30	mice	mouse	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	HOX11	hox11	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	subset	subset	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	T-cell	t-cell	NN	NN	_	11	compound	_	_
10	acute	acute	JJ	JJ	_	11	amod	_	_
11	leukemias	leukemia	NNS	NNS	_	7	nmod	_	_
12	after	after	IN	IN	_	15	case	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	chromosomal	chromosomal	JJ	JJ	_	15	amod	_	_
15	translocations	translocation	NNS	NNS	_	4	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	14	advcl	_	_
5	a	a	DT	DT	_	6	det	_	_
6	homeodomain	homeodomain	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	activate	activate	VB	VB	_	4	conj	_	_
10	transcription	transcription	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	14	punct	_	_
12	it	it	PRP	PRP	_	14	nsubj	_	_
13	probably	probably	RB	RB	_	14	advmod	_	_
14	exerts	exert	VBZ	VBZ	_	0	root	_	_
15	at	at	IN	IN	_	14	advmod	_	_
16	least	least	JJS	JJS	_	15	mwe	_	_
17	some	some	DT	DT	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	effects	effect	NNS	NNS	_	17	nmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vivo	vivo	FW	FW	_	14	advmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	regulation	regulation	NN	NN	_	14	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	target	target	NN	NN	_	27	compound	_	_
27	genes	gene	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	14	punct	_	_

1	Representational	representational	JJ	JJ	_	3	amod	_	_
2	difference	difference	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	isolate	isolate	VB	VB	_	6	xcomp	_	_
9	cDNA	cdna	NN	NN	_	10	compound	_	_
10	clones	clone	NNS	NNS	_	8	dobj	_	_
11	corresponding	correspond	VBG	VBG	_	10	acl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	species	species	NNS	NNS	_	11	nmod	_	_
15	activated	activate	VBN	VBN	_	14	acl	_	_
16	following	follow	VBG	VBG	_	18	case	_	_
17	stable	stable	JJ	JJ	_	18	amod	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	HOX11	hox11	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	NIH	nih	NN	NN	_	24	compound	_	_
23	3T3	3t3	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	20	nsubjpass	_	_
3	encoding	encode	VBG	VBG	_	2	acl	_	_
4	the	the	DT	DT	_	7	det	_	_
5	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
6	acid-synthesizing	acid-synthesizing	JJ	JJ	_	7	amod	_	_
7	enzyme	enzyme	NN	NN	_	3	dobj	_	_
8	aldehyde	aldehyde	NN	NN	_	9	compound	_	_
9	dehydrogenase	dehydrogenase	NN	NN	_	7	dep	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Aldh1	aldh1	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	2	punct	_	_
15	initially	initially	RB	RB	_	16	advmod	_	_
16	called	call	VBN	VBN	_	2	acl	_	_
17	Hdg-1	hdg-1	NN	NN	_	16	xcomp	_	_
18	,	,	,	,	_	2	punct	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	to	to	TO	TO	_	24	mark	_	_
22	be	be	VB	VB	_	24	auxpass	_	_
23	ectopically	ectopically	RB	RB	_	24	advmod	_	_
24	activated	activate	VBN	VBN	_	20	xcomp	_	_
25	by	by	IN	IN	_	26	case	_	_
26	HOX11	hox11	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	system	system	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	Study	study	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Aldh1	aldh1	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	spleen	spleen	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	5	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	17	nsubj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Aldh1	aldh1	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	12	nmod	_	_
16	inversely	inversely	RB	RB	_	17	advmod	_	_
17	correlated	correlate	VBD	VBD	_	9	ccomp	_	_
18	with	with	IN	IN	_	19	case	_	_
19	Hox11	hox11	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Hox11	hox11	NN	NN	_	4	compound	_	_
2	null	null	JJ	JJ	_	4	amod	_	_
3	mouse	mouse	NN	NN	_	4	compound	_	_
4	embryos	embryo	NNS	NNS	_	5	nsubj	_	_
5	have	have	VBP	VBP	_	0	root	_	_
6	elevated	elevated	JJ	JJ	_	8	amod	_	_
7	Aldh1	aldh1	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	spleen	spleen	NN	NN	_	11	compound	_	_
11	primordia	primordia	NN	NN	_	5	nmod	_	_
12	prior	prior	JJ	JJ	_	14	case	_	_
13	to	to	TO	TO	_	12	mwe	_	_
14	atrophy	atrophy	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	while	while	IN	IN	_	18	mark	_	_
17	Aldh1	aldh1	NN	NN	_	18	nsubj	_	_
18	seems	seem	VBZ	VBZ	_	5	advcl	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	repressed	repress	VBN	VBN	_	18	xcomp	_	_
22	by	by	IN	IN	_	23	case	_	_
23	Hox11	hox11	NN	NN	_	21	nmod	_	_
24	during	during	IN	IN	_	25	case	_	_
25	organogenesis	organogenesis	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	spleens	spleen	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	wild-type	wild-type	JJ	JJ	_	31	amod	_	_
31	mice	mouse	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	expression	expression	NN	NN	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Aldh1	aldh1	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	negatively	negatively	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	Hox11	hox11	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	that	that	IN	IN	_	25	mark	_	_
16	abnormal	abnormal	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	25	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Aldh1	aldh1	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	Hox11	hox11	NN	NN	_	23	compound	_	_
22	null	null	JJ	JJ	_	23	amod	_	_
23	mice	mouse	NNS	NNS	_	17	nmod	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	cause	cause	VB	VB	_	11	conj	_	_
26	loss	loss	NN	NN	_	25	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	splenic	splenic	JJ	JJ	_	30	amod	_	_
29	precursor	precursor	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	by	by	IN	IN	_	35	case	_	_
32	aberrant	aberrant	JJ	JJ	_	35	amod	_	_
33	retinoic	retinoic	JJ	JJ	_	35	amod	_	_
34	acid	acid	NN	NN	_	35	compound	_	_
35	metabolism	metabolism	NN	NN	_	26	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Granulocyte	granulocyte	NN	NN	_	3	compound	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	72-kDa	72-kda	JJ	JJ	_	7	amod	_	_
7	isoform	isoform	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	STAT3	stat3	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Granulocyte	granulocyte	NN	NN	_	3	compound	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	G-CSF	g-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	signaling	signaling	NN	NN	_	8	nsubj	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	activation	activation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	STATs	stats	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	proteins	protein	NNS	NNS	_	11	appos	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	serve	serve	VBP	VBP	_	13	acl:relcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	dual	dual	JJ	JJ	_	18	amod	_	_
18	function	function	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	signal	signal	NN	NN	_	21	compound	_	_
21	transduction	transduction	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	activation	activation	NN	NN	_	21	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	transcription	transcription	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	G-CSF	g-csf	NN	NN	_	6	nsubj	_	_
6	activated	activate	VBD	VBD	_	3	ccomp	_	_
7	a	a	DT	DT	_	10	det	_	_
8	distinct	distinct	JJ	JJ	_	10	amod	_	_
9	Stat3-like	stat3-like	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	6	dobj	_	_
11	in	in	IN	IN	_	17	case	_	_
12	immature	immature	JJ	JJ	_	17	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	mature	mature	JJ	JJ	_	12	conj	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	StatG	statg	NN	NN	_	10	appos	_	_
20	.	.	.	.	_	3	punct	_	_

1	StatG	statg	NN	NN	_	17	nsubjpass	_	_
2	in	in	IN	IN	_	7	case	_	_
3	normal	normal	JJ	JJ	_	7	amod	_	_
4	immature	immature	JJ	JJ	_	7	amod	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	i.e.	i.e.	FW	FW	_	14	dep	_	_
10	adult	adult	JJ	JJ	_	14	amod	_	_
11	CD34+	cd34+	JJ	JJ	_	14	amod	_	_
12	bone	bone	NN	NN	_	14	compound	_	_
13	marrow	marrow	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	composed	compose	VBN	VBN	_	0	root	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Stat3beta	stat3beta	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	investigation	investigation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	undertaken	undertake	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	determine	determine	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	composition	composition	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	StatG	statg	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	mature	mature	JJ	JJ	_	16	amod	_	_
13	normal	normal	JJ	JJ	_	16	amod	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	i.e.	i.e.	FW	FW	_	21	dep	_	_
19	polymorphonuclear	polymorphonuclear	JJ	JJ	_	21	amod	_	_
20	neutrophilic	neutrophilic	JJ	JJ	_	21	amod	_	_
21	granulocytes	granulocyte	NNS	NNS	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PMN	pmn	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	27	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	major	major	JJ	JJ	_	7	amod	_	_
7	protein	protein	NN	NN	_	27	nsubj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	extracts	extract	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PMN	pmn	NN	NN	_	9	nmod	_	_
12	activated	activate	VBN	VBN	_	7	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	G-CSF	g-csf	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	bind	bind	VB	VB	_	12	xcomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	high-affinity	high-affinity	JJ	JJ	_	20	amod	_	_
19	serum-inducible	serum-inducible	JJ	JJ	_	20	amod	_	_
20	element	element	NN	NN	_	16	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	hSIE	hsie	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	is	be	VBZ	VBZ	_	27	cop	_	_
25	a	a	DT	DT	_	27	det	_	_
26	72-kDa	72-kda	JJ	JJ	_	27	amod	_	_
27	protein	protein	NN	NN	_	3	ccomp	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	cross-reacts	cross-react	VBZ	VBZ	_	27	acl:relcl	_	_
30	with	with	IN	IN	_	33	case	_	_
31	Stat3	stat3	NN	NN	_	33	compound	_	_
32	monoclonal	monoclonal	JJ	JJ	_	33	amod	_	_
33	antibody	antibody	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	which	which	WDT	WDT	_	39	dobj	_	_
36	we	we	PRP	PRP	_	38	nsubj	_	_
37	have	have	VBP	VBP	_	38	aux	_	_
38	designated	designate	VBN	VBN	_	33	acl:relcl	_	_
39	Stat3gamma	stat3gamma	NN	NN	_	38	xcomp	_	_
40	.	.	.	.	_	3	punct	_	_

1	Stat3gamma	stat3gamma	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	derived	derive	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	5	case	_	_
5	Stat3alpha	stat3alpha	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	limited	limited	JJ	JJ	_	8	amod	_	_
8	proteolysis	proteolysis	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	lacks	lack	VBZ	VBZ	_	3	conj	_	_
11	the	the	DT	DT	_	13	det	_	_
12	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	13	amod	_	_
13	portion	portion	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Stat3alpha	stat3alpha	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	this	this	DT	DT	_	3	det	_	_
3	region	region	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Stat3alpha	stat3alpha	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	14	advcl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	our	we	PRP$	PRP$	_	13	nmod:poss	_	_
13	findings	finding	NNS	NNS	_	14	nsubj	_	_
14	suggest	suggest	VBP	VBP	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	possibility	possibility	NN	NN	_	14	dobj	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	Stat3gamma	stat3gamma	NN	NN	_	22	nsubj	_	_
19	may	may	MD	MD	_	22	aux	_	_
20	be	be	VB	VB	_	22	cop	_	_
21	transcriptionally	transcriptionally	RB	RB	_	22	advmod	_	_
22	inactive	inactive	JJ	JJ	_	16	ccomp	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	compete	compete	VB	VB	_	22	conj	_	_
26	with	with	IN	IN	_	27	case	_	_
27	Stat3alpha	stat3alpha	NN	NN	_	25	nmod	_	_
28	for	for	IN	IN	_	31	case	_	_
29	Stat3	stat3	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	25	nmod	_	_
32	in	in	IN	IN	_	37	case	_	_
33	these	these	DT	DT	_	37	det	_	_
34	terminally	terminally	RB	RB	_	37	advmod	_	_
35	differentiated	differentiate	VBN	VBN	_	37	amod	_	_
36	myeloid	myeloid	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	25	nmod	_	_
38	.	.	.	.	_	14	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	protein	protein	NN	NN	_	7	compound	_	_
5	kinase	kinase	NN	NN	_	7	compound	_	_
6	C	c	NN	NN	_	7	compound	_	_
7	inhibitors	inhibitor	NNS	NNS	_	2	nmod	_	_
8	on	on	IN	IN	_	12	case	_	_
9	fibronectin-induced	fibronectin-induced	JJ	JJ	_	12	amod	_	_
10	interleukin-beta	interleukin-beta	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	transcription	transcription	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	synthesis	synthesis	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	secretion	secretion	NN	NN	_	12	conj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	12	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	monocytic	monocytic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	express	express	VBP	VBP	_	0	root	_	_
5	interleukin-1beta	interleukin-1beta	NN	NN	_	4	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-1beta	il-1beta	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	stimulated	stimulate	VBN	VBN	_	4	advcl	_	_
11	with	with	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	extracellular	extracellular	JJ	JJ	_	15	amod	_	_
14	matrix	matrix	NN	NN	_	15	compound	_	_
15	glycoprotein	glycoprotein	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	fibronectin	fibronectin	NN	NN	_	15	appos	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	FN	fn	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	4	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PKC	pkc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	activation	activation	NN	NN	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	considered	consider	VBN	VBN	_	0	root	_	_
10	important	important	JJ	JJ	_	9	xcomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	process	process	NN	NN	_	10	nmod	_	_
14	;	;	:	:	_	9	punct	_	_
15	however	however	RB	RB	_	9	advmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	metabolic	metabolic	JJ	JJ	_	19	amod	_	_
19	steps	step	NNS	NNS	_	31	nsubj	_	_
20	at	at	IN	IN	_	21	case	_	_
21	which	which	WDT	WDT	_	23	nmod	_	_
22	PKC	pkc	NN	NN	_	23	nsubj	_	_
23	acts	act	VBZ	VBZ	_	19	acl:relcl	_	_
24	upon	upon	IN	IN	_	23	compound:prt	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	mediate	mediate	VB	VB	_	23	xcomp	_	_
27	the	the	DT	DT	_	30	det	_	_
28	FN-induced	fn-induced	JJ	JJ	_	30	amod	_	_
29	IL-1beta	il-1beta	NN	NN	_	30	compound	_	_
30	response	response	NN	NN	_	26	dobj	_	_
31	remain	remain	VBP	VBP	_	9	dep	_	_
32	unclear	unclear	JJ	JJ	_	31	xcomp	_	_
33	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	performed	perform	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	analysis	analysis	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	19	nmod	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	PKC	pkc	NN	NN	_	12	compound	_	_
12	inhibitors	inhibitor	NNS	NNS	_	19	nsubj	_	_
13	,	,	,	,	_	12	punct	_	_
14	Calphostin	calphostin	NN	NN	_	15	compound	_	_
15	C	c	NN	NN	_	12	appos	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Staurosporine	staurosporine	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	prevent	prevent	VBP	VBP	_	7	acl:relcl	_	_
20	the	the	DT	DT	_	23	det	_	_
21	FN-induced	fn-induced	JJ	JJ	_	23	amod	_	_
22	IL-1beta	il-1beta	NN	NN	_	23	compound	_	_
23	response	response	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	inhibitors	inhibitor	NNS	NNS	_	3	nsubj	_	_
3	blocked	block	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	secretion	secretion	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	IL-1beta	il-1beta	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	into	into	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	media	media	NNS	NNS	_	5	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	exposed	expose	VBN	VBN	_	16	acl	_	_
18	to	to	TO	TO	_	19	case	_	_
19	FN	fn	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Immunoprecipitation	immunoprecipitation	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	under	under	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	circumstances	circumstance	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	Calphostin	calphostin	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	11	nsubj	_	_
11	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	IL-1beta	il-1beta	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	whereas	whereas	IN	IN	_	20	mark	_	_
19	Staurosporine	staurosporine	NN	NN	_	20	nsubj	_	_
20	allowed	allow	VBD	VBD	_	11	advcl	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	20	punct	_	_
24	but	but	CC	CC	_	20	cc	_	_
25	inhibited	inhibit	VBD	VBD	_	20	conj	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	secretion	secretion	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	11	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	responsible	responsible	JJ	JJ	_	4	amod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	differences	difference	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	turned	turn	VBD	VBD	_	0	root	_	_
12	to	to	TO	TO	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	U937	u937	NN	NN	_	16	compound	_	_
15	promonocytic	promonocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	U937	u937	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	17	nsubjpass	_	_
3	transfected	transfect	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	full-length	full-length	JJ	JJ	_	9	amod	_	_
8	IL-1beta	il-1beta	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	3	nmod	_	_
10	connected	connect	VBN	VBN	_	9	acl	_	_
11	to	to	TO	TO	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	luciferase	luciferase	NN	NN	_	15	compound	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	submitted	submit	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	assays	assay	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	Northern	northern	NN	NN	_	23	compound	_	_
23	blotting	blotting	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	DNA	dna	NN	NN	_	31	compound	_	_
27	electrophoresis	electrophoresis	NN	NN	_	31	compound	_	_
28	mobility	mobility	NN	NN	_	31	compound	_	_
29	gel	gel	NN	NN	_	31	compound	_	_
30	shift	shift	NN	NN	_	31	compound	_	_
31	assays	assay	NNS	NNS	_	20	conj	_	_
32	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Calphostin	calphostin	NN	NN	_	6	compound	_	_
6	C	c	NN	NN	_	7	nsubj	_	_
7	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	transcription	transcription	NN	NN	_	16	compound	_	_
14	factor	factor	NN	NN	_	16	compound	_	_
15	activator	activator	NN	NN	_	16	compound	_	_
16	protein-1	protein-1	NN	NN	_	10	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	AP-1	ap-1	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	which	which	WDT	WDT	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	considered	consider	VBN	VBN	_	16	acl:relcl	_	_
23	necessary	necessary	JJ	JJ	_	22	xcomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	FN	fn	NN	NN	_	26	compound	_	_
26	induction	induction	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	IL-1beta	il-1beta	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	transcription	transcription	NN	NN	_	26	nmod	_	_
31	,	,	,	,	_	7	punct	_	_
32	and	and	CC	CC	_	7	cc	_	_
33	prevented	prevent	VBD	VBD	_	7	conj	_	_
34	the	the	DT	DT	_	35	det	_	_
35	transcription	transcription	NN	NN	_	33	dobj	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	IL-1beta	il-1beta	NN	NN	_	39	compound	_	_
39	gene	gene	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	Staurosporine	staurosporine	NN	NN	_	6	nsubj	_	_
5	alone	alone	RB	RB	_	4	advmod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	translocation	translocation	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	stimulation	stimulation	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	gene	gene	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Overall	overall	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Calphostin	calphostin	NN	NN	_	8	compound	_	_
8	C	c	NN	NN	_	9	nsubj	_	_
9	prevents	prevent	VBZ	VBZ	_	5	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-1beta	il-1beta	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	thereby	thereby	RB	RB	_	17	advmod	_	_
17	inhibiting	inhibit	VBG	VBG	_	9	xcomp	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	synthesis	synthesis	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Based	base	VBN	VBN	_	5	case	_	_
2	on	on	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	specificity	specificity	NN	NN	_	13	advcl	_	_
6	of	of	IN	IN	_	8	case	_	_
7	this	this	DT	DT	_	8	det	_	_
8	compound	compound	NN	NN	_	5	nmod	_	_
9	for	for	IN	IN	_	10	case	_	_
10	PKC	pkc	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	conclude	conclude	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	PKC	pkc	NN	NN	_	17	nsubj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	necessary	necessary	JJ	JJ	_	13	ccomp	_	_
18	for	for	IN	IN	_	22	case	_	_
19	FN-induced	fn-induced	JJ	JJ	_	22	amod	_	_
20	IL-1beta	il-1beta	NN	NN	_	22	compound	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	Staurosporine	staurosporine	NN	NN	_	5	nsubj	_	_
5	prevented	prevent	VBD	VBD	_	0	root	_	_
6	secretion	secretion	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-1beta	il-1beta	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	unknown	unknown	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Membrane-associated	membrane-associated	JJ	JJ	_	2	amod	_	_
2	lymphotoxin	lymphotoxin	NN	NN	_	7	nsubj	_	_
3	on	on	IN	IN	_	6	case	_	_
4	natural	natural	JJ	JJ	_	6	amod	_	_
5	killer	killer	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	activates	activate	VBZ	VBZ	_	0	root	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	7	dobj	_	_
10	via	via	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	13	amod	_	_
13	pathway	pathway	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Inhibition	inhibition	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	complement	complement	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	small	small	JJ	JJ	_	9	amod	_	_
8	animal	animal	NN	NN	_	9	compound	_	_
9	models	model	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	xenotransplantation	xenotransplantation	NN	NN	_	9	nmod	_	_
12	has	have	VBZ	VBZ	_	13	aux	_	_
13	demonstrated	demonstrate	VBN	VBN	_	1	appos	_	_
14	graft	graft	NN	NN	_	15	compound	_	_
15	infiltration	infiltration	NN	NN	_	13	dobj	_	_
16	with	with	IN	IN	_	22	case	_	_
17	natural	natural	JJ	JJ	_	22	amod	_	_
18	killer	killer	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	NK	nk	NN	NN	_	22	compound	_	_
21	)	)	-RRB-	-RRB-	_	22	punct	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	monocytes	monocyte	NNS	NNS	_	22	conj	_	_
25	associated	associate	VBN	VBN	_	22	acl	_	_
26	with	with	IN	IN	_	32	case	_	_
27	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
28	cell	cell	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	EC	ec	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	activation	activation	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	NK	nk	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	9	nsubj	_	_
9	activate	activate	VBP	VBP	_	4	ccomp	_	_
10	porcine	porcine	NN	NN	_	11	compound	_	_
11	EC	ec	NN	NN	_	9	dobj	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	9	advmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	results	result	VBZ	VBZ	_	9	ccomp	_	_
17	in	in	IN	IN	_	20	case	_	_
18	adhesion	adhesion	NN	NN	_	20	compound	_	_
19	molecule	molecule	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	cytokine	cytokine	NN	NN	_	23	compound	_	_
23	secretion	secretion	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	used	use	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	11	det	_	_
8	NK	nk	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	line	line	NN	NN	_	11	compound	_	_
11	NK92	nk92	NN	NN	_	6	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	define	define	VB	VB	_	6	advcl	_	_
14	the	the	DT	DT	_	18	det	_	_
15	molecular	molecular	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cellular	cellular	JJ	JJ	_	15	conj	_	_
18	basis	basis	NN	NN	_	13	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	NK	nk	NN	NN	_	21	nmod:npmod	_	_
21	cell-mediated	cell-mediated	JJ	JJ	_	23	amod	_	_
22	EC	ec	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	EC	ec	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	transfected	transfect	VBN	VBN	_	1	appos	_	_
6	with	with	IN	IN	_	9	case	_	_
7	either	either	CC	CC	_	9	dep	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	constructs	construct	NNS	NNS	_	5	nmod	_	_
10	containing	contain	VBG	VBG	_	9	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	luciferase	luciferase	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	10	dobj	_	_
14	driven	drive	VBN	VBN	_	13	acl	_	_
15	either	either	CC	CC	_	24	dep	_	_
16	by	by	IN	IN	_	24	case	_	_
17	E-selectin	e-selectin	NN	NN	_	24	compound	_	_
18	or	or	CC	CC	_	24	cc	_	_
19	interleukin	interleukin	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	IL	il	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	-8	-8	CD	CD	_	24	nummod	_	_
24	promoters	promoter	NNS	NNS	_	14	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	a	a	DT	DT	_	29	det	_	_
27	synthetic	synthetic	JJ	JJ	_	29	amod	_	_
28	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	29	amod	_	_
29	promoter	promoter	NN	NN	_	24	conj	_	_
30	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	a	a	DT	DT	_	16	det	_	_
5	dominant-negative	dominant-negative	JJ	JJ	_	16	amod	_	_
6	mutant	mutant	JJ	JJ	_	16	amod	_	_
7	tumor	tumor	NN	NN	_	16	compound	_	_
8	necrosis	necrosis	NN	NN	_	16	compound	_	_
9	factor	factor	NN	NN	_	16	compound	_	_
10	receptor	receptor	NN	NN	_	16	compound	_	_
11	I	i	CD	CD	_	16	nummod	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	TNFRI	tnfri	NN	NN	_	16	compound	_	_
14	)	)	-RRB-	-RRB-	_	16	punct	_	_
15	expression	expression	NN	NN	_	16	compound	_	_
16	vector	vector	NN	NN	_	18	nsubjpass	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	co-transfected	co-transfect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	inhibition	inhibition	NN	NN	_	21	compound	_	_
21	studies	study	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	18	punct	_	_

1	Forty-eight	forty-eight	CD	CD	_	2	nummod	_	_
2	hours	hour	NNS	NNS	_	8	nmod	_	_
3	after	after	IN	IN	_	2	case	_	_
4	transfection	transfection	NN	NN	_	2	dep	_	_
5	,	,	,	,	_	8	punct	_	_
6	EC	ec	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	stimulated	stimulate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	NK	nk	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	NK	nk	NN	NN	_	16	compound	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	membrane	membrane	NN	NN	_	16	compound	_	_
16	extracts	extract	NNS	NNS	_	11	conj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	7	7	CD	CD	_	19	nummod	_	_
19	hr	hr	NN	NN	_	8	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	activation	activation	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	measured	measure	VBN	VBN	_	8	conj	_	_
24	by	by	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	luciferase	luciferase	NN	NN	_	27	compound	_	_
27	assay	assay	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Co-culture	co-culture	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NK	nk	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	transfected	transfect	VBN	VBN	_	9	amod	_	_
9	EC	ec	NN	NN	_	3	nmod	_	_
10	enhanced	enhance	VBD	VBD	_	1	appos	_	_
11	E-selectin	e-selectin	NN	NN	_	13	compound	_	_
12	,	,	,	,	_	13	punct	_	_
13	IL-8	il-8	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	18	amod	_	_
17	promoter	promoter	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	1	punct	_	_

1	NK	nk	NN	NN	_	4	compound	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	membrane	membrane	NN	NN	_	4	compound	_	_
4	extracts	extract	NNS	NNS	_	5	nsubj	_	_
5	retained	retain	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	capacity	capacity	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	acl	_	_
10	EC	ec	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	induced	induce	VBD	VBD	_	5	conj	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	translocation	translocation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	p50	p50	NN	NN	_	16	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p65	p65	NN	NN	_	18	conj	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	.	.	.	.	_	5	punct	_	_

1	Western	western	NN	NN	_	2	compound	_	_
2	blotting	blotting	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NK	nk	NN	NN	_	5	compound	_	_
5	cell	cell	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	membrane	membrane	NN	NN	_	8	compound	_	_
8	extracts	extract	NNS	NNS	_	5	conj	_	_
9	detected	detect	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Lymphotoxin-alpha	lymphotoxin-alpha	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	LTalpha	ltalpha	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	13	cc	_	_
19	tumor	tumor	NN	NN	_	21	compound	_	_
20	necrosis	necrosis	NN	NN	_	21	compound	_	_
21	factor-alpha	factor-alpha	NN	NN	_	13	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	LTalpha	ltalpha	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	secreted	secrete	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	NK:EC	nk:ec	NN	NN	_	8	compound	_	_
8	co-cultures	co-culture	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	Co-transfection	co-transfection	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	dominant-negative	dominant-negative	JJ	JJ	_	5	amod	_	_
4	mutant	mutant	JJ	JJ	_	5	amod	_	_
5	TNFRI	tnfri	NN	NN	_	1	nmod	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	EC	ec	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	by	by	IN	IN	_	13	case	_	_
10	NK	nk	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	membrane	membrane	NN	NN	_	13	compound	_	_
13	extracts	extract	NNS	NNS	_	6	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	by	by	IN	IN	_	17	case	_	_
16	NK	nk	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	conj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	80	80	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	6	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	47	47	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	respectively	respectively	RB	RB	_	20	advmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	same	same	JJ	JJ	_	3	amod	_	_
3	pattern	pattern	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	inhibition	inhibition	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	anti-human	anti-human	JJ	JJ	_	11	amod	_	_
10	LT	lt	NN	NN	_	11	compound	_	_
11	sera	serum	NNS	NNS	_	8	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Human	human	JJ	JJ	_	6	amod	_	_
4	NK	nk	NN	NN	_	6	nmod:npmod	_	_
5	cell	cell	NN	NN	_	6	nmod:npmod	_	_
6	membrane-bound	membrane-bound	JJ	JJ	_	7	amod	_	_
7	LT	lt	NN	NN	_	8	nsubj	_	_
8	signals	signal	VBZ	VBZ	_	1	appos	_	_
9	across	across	IN	IN	_	10	case	_	_
10	species	species	NNS	NNS	_	8	nmod	_	_
11	via	via	IN	IN	_	12	case	_	_
12	TNFRI	tnfri	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	leading	lead	VBG	VBG	_	8	xcomp	_	_
15	to	to	TO	TO	_	18	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	translocation	translocation	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	transcription	transcription	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	E-selectin	e-selectin	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-8	il-8	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	results	result	VBZ	VBZ	_	20	acl:relcl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	EC	ec	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	discrepancy	discrepancy	NN	NN	_	17	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	degree	degree	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	inhibition	inhibition	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	membrane	membrane	NN	NN	_	10	compound	_	_
10	extracts	extract	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NK	nk	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	mutant	mutant	JJ	JJ	_	16	amod	_	_
16	TNFRI	tnfri	NN	NN	_	7	nmod	_	_
17	suggests	suggest	VBZ	VBZ	_	0	root	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	additional	additional	JJ	JJ	_	20	amod	_	_
20	pathways	pathway	NNS	NNS	_	22	nsubjpass	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	utilized	utilize	VBN	VBN	_	17	ccomp	_	_
23	by	by	IN	IN	_	25	case	_	_
24	NK	nk	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	activate	activate	VB	VB	_	22	xcomp	_	_
28	EC	ec	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	17	punct	_	_

1	Triptolide	triptolide	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	apoptotic	apoptotic	JJ	JJ	_	4	amod	_	_
4	death	death	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Extract	extract	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	Tripterygium	tripterygium	FW	FW	_	6	compound	_	_
4	wilfordii	wilfordii	FW	FW	_	6	compound	_	_
5	Hook.	hook.	FW	FW	_	6	compound	_	_
6	f	f	FW	FW	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TWHf	twhf	FW	FW	_	6	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	has	have	VBZ	VBZ	_	0	root	_	_
11	immunosuppressive	immunosuppressive	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	used	use	VBN	VBN	_	10	conj	_	_
17	as	as	IN	IN	_	19	case	_	_
18	anti-inflammatory	anti-inflammatory	JJ	JJ	_	19	amod	_	_
19	agent	agent	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	traditional	traditional	JJ	JJ	_	23	amod	_	_
22	Chinese	chinese	JJ	JJ	_	23	amod	_	_
23	medicine	medicine	NN	NN	_	19	nmod	_	_
24	for	for	IN	IN	_	25	case	_	_
25	centuries	century	NNS	NNS	_	16	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	triptolide	triptolide	NN	NN	_	11	nsubj	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	the	the	DT	DT	_	11	det	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	active	active	JJ	JJ	_	11	amod	_	_
11	component	component	NN	NN	_	4	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	extract	extract	NN	NN	_	11	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	inhibits	inhibit	VBZ	VBZ	_	11	acl:relcl	_	_
17	antigen	antigen	NN	NN	_	22	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	mitogen-induced	mitogen-induced	JJ	JJ	_	17	conj	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	proliferation	proliferation	NN	NN	_	16	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	attempting	attempt	VBG	VBG	_	14	advcl	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	investigate	investigate	VB	VB	_	2	xcomp	_	_
5	its	its	PRP$	PRP$	_	6	nmod:poss	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	on	on	IN	IN	_	8	case	_	_
8	activation	activation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	found	find	VBD	VBD	_	0	root	_	_
15	triptolide	triptolide	NN	NN	_	16	nsubj	_	_
16	induces	induce	VBZ	VBZ	_	14	ccomp	_	_
17	apoptotic	apoptotic	JJ	JJ	_	18	amod	_	_
18	death	death	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	hybridomas	hybridoma	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	conj	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	18	cc	_	_
29	that	that	DT	DT	_	18	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	thymocytes	thymocyte	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	triptolide-induced	triptolide-induced	JJ	JJ	_	3	amod	_	_
3	apoptosis	apoptosis	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	accompanied	accompany	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	increase	increase	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	DEVD-cleavable	devd-cleavable	JJ	JJ	_	11	amod	_	_
10	caspases	caspase	NNS	NNS	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	degradation	degradation	NN	NN	_	7	conj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	caspase	caspase	NN	NN	_	21	compound	_	_
16	substrate	substrate	NN	NN	_	21	compound	_	_
17	poly	poly	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	ADP-ribose	adp-ribose	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	polymerase	polymerase	NN	NN	_	13	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PARP	parp	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	inhibitor	inhibitor	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	caspases	caspase	NNS	NNS	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	zVAD-FMK	zvad-fmk	NN	NN	_	3	appos	_	_
8	,	,	,	,	_	3	punct	_	_
9	prevents	prevent	VBZ	VBZ	_	0	root	_	_
10	triptolide-induced	triptolide-induced	JJ	JJ	_	12	amod	_	_
11	PARP	parp	NN	NN	_	12	compound	_	_
12	degradation	degradation	NN	NN	_	9	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	fragmentation	fragmentation	NN	NN	_	12	conj	_	_
16	but	but	CC	CC	_	17	cc	_	_
17	not	not	RB	RB	_	12	cc	_	_
18	growth	growth	NN	NN	_	19	compound	_	_
19	arrest	arrest	NN	NN	_	12	conj	_	_
20	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	enforced	enforce	VBN	VBN	_	4	amod	_	_
4	expression	expression	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Bcl-2	bcl-2	NN	NN	_	4	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	triptolide-induced	triptolide-induced	JJ	JJ	_	9	amod	_	_
9	degradation	degradation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	PARP	parp	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	apoptosis	apoptosis	NN	NN	_	9	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	triptolide	triptolide	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	apoptosis	apoptosis	NN	NN	_	6	dobj	_	_
10	through	through	IN	IN	_	11	mark	_	_
11	activating	activate	VBG	VBG	_	6	advcl	_	_
12	caspases	caspase	NNS	NNS	_	11	dep	_	_
13	,	,	,	,	_	3	punct	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	suggest	suggest	VBP	VBP	_	3	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	growth	growth	NN	NN	_	18	compound	_	_
18	arrest	arrest	NN	NN	_	25	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	apoptotic	apoptotic	JJ	JJ	_	21	amod	_	_
21	effect	effect	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	triptolide	triptolide	NN	NN	_	18	nmod	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	contribute	contribute	VB	VB	_	15	ccomp	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	immunosuppressive	immunosuppressive	JJ	JJ	_	29	amod	_	_
29	activity	activity	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	TWHf	twhf	FW	FW	_	32	compound	_	_
32	extract	extract	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	2	compound	_	_
2	proto-oncogene	proto-oncogene	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	opposite	opposite	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	on	on	IN	IN	_	10	case	_	_
7	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	erythroid	erythroid	JJ	JJ	_	7	conj	_	_
10	differentiation	differentiation	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	K562	k562	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Spi-1/PU.1	spi-1/pu.1	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	hematopoietic	hematopoietic	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Ets	ets	NN	NN	_	10	compound	_	_
10	family	family	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	analyze	analyze	VB	VB	_	23	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	ectopic	ectopic	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	spi-1	spi-1	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	proliferation/differentiation	proliferation/differentiation	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
16	leukemia	leukemia	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	23	punct	_	_
19	K562	k562	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	23	nsubjpass	_	_
21	were	be	VBD	VBD	_	23	auxpass	_	_
22	stably	stably	RB	RB	_	23	advmod	_	_
23	transfected	transfect	VBN	VBN	_	0	root	_	_
24	with	with	IN	IN	_	28	case	_	_
25	a	a	DT	DT	_	28	det	_	_
26	spi-1	spi-1	NN	NN	_	28	compound	_	_
27	expression	expression	NN	NN	_	28	compound	_	_
28	vector	vector	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transfected	transfect	VBN	VBN	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	elevated	elevated	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	spi-1	spi-1	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	high	high	JJ	JJ	_	17	amod	_	_
15	Spi-1-DNA	spi-1-dna	JJ	JJ	_	17	amod	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	7	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	spi-1	spi-1	NN	NN	_	4	compound	_	_
3	transfected	transfected	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	reduced	reduce	VBN	VBN	_	8	amod	_	_
7	growth	growth	NN	NN	_	8	compound	_	_
8	rates	rate	NNS	NNS	_	5	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	reduced	reduce	VBN	VBN	_	13	amod	_	_
11	clonogenic	clonogenic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	growth	growth	NN	NN	_	8	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	9	advmod	_	_
2	the	the	DT	DT	_	7	det	_	_
3	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	monocytic	monocytic	JJ	JJ	_	3	conj	_	_
6	differentiation	differentiation	NN	NN	_	7	compound	_	_
7	markers	marker	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	analyzed	analyze	VBN	VBN	_	13	advcl	_	_
10	,	,	,	,	_	13	punct	_	_
11	spi-1	spi-1	NN	NN	_	12	compound	_	_
12	overexpression	overexpression	NN	NN	_	13	nsubj	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	opposite	opposite	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	13	nmod	_	_
17	:	:	:	:	_	13	punct	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	22	nsubjpass	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	inhibited	inhibit	VBN	VBN	_	13	parataxis	_	_
23	in	in	IN	IN	_	25	case	_	_
24	spi-1	spi-1	NN	NN	_	25	compound	_	_
25	transfectants	transfectant	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	22	punct	_	_
27	while	while	IN	IN	_	30	mark	_	_
28	spi-1	spi-1	NN	NN	_	29	compound	_	_
29	overexpression	overexpression	NN	NN	_	30	nsubj	_	_
30	increased	increase	VBD	VBD	_	22	advcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	monocytic	monocytic	JJ	JJ	_	33	amod	_	_
33	differentiation	differentiation	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	cells	cell	NNS	NNS	_	33	nmod	_	_
36	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	differential	differential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Spi-1	spi-1	NN	NN	_	6	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	differentiation	differentiation	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
15	leukemia	leukemia	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	gene	gene	NN	NN	_	16	nsubj	_	_
4	encoding	encode	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	9	det	_	_
6	lectin-type	lectin-type	JJ	JJ	_	9	amod	_	_
7	oxidized	oxidize	VBN	VBN	_	9	amod	_	_
8	LDL	ldl	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	4	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	OLR1	olr1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	novel	novel	JJ	JJ	_	16	amod	_	_
16	member	member	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	natural	natural	JJ	JJ	_	22	amod	_	_
20	killer	killer	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	complex	complex	NN	NN	_	16	nmod	_	_
23	with	with	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	unique	unique	JJ	JJ	_	27	amod	_	_
26	expression	expression	NN	NN	_	27	compound	_	_
27	profile	profile	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	LOX-1	lox-1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	an	a	DT	DT	_	5	det	_	_
4	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
5	receptor	receptor	NN	NN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	oxidized	oxidize	VBN	VBN	_	9	amod	_	_
8	low-density	low-density	JJ	JJ	_	9	amod	_	_
9	lipoprotein	lipoprotein	NN	NN	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	plays	play	VBZ	VBZ	_	9	acl:relcl	_	_
12	essential	essential	JJ	JJ	_	13	amod	_	_
13	roles	role	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	atherogenesis	atherogenesis	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	LOX-1	lox-1	NN	NN	_	2	nsubj	_	_
2	has	have	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	highest	highest	JJS	JJS	_	5	amod	_	_
5	homology	homology	NN	NN	_	2	dobj	_	_
6	with	with	IN	IN	_	9	case	_	_
7	C-type	c-type	JJ	JJ	_	9	amod	_	_
8	lectin	lectin	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	5	nmod	_	_
10	expressed	express	VBN	VBN	_	9	acl	_	_
11	on	on	IN	IN	_	14	case	_	_
12	natural	natural	JJ	JJ	_	14	amod	_	_
13	killer	killer	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	cloned	clone	VBD	VBD	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	characterized	characterize	VBD	VBD	_	7	conj	_	_
10	the	the	DT	DT	_	13	det	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	LOX-1	lox-1	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	7	dobj	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	HGMW-approved	hgmw-approved	JJ	JJ	_	17	amod	_	_
16	symbol	symbol	NN	NN	_	17	compound	_	_
17	OLR1	olr1	NN	NN	_	13	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	structure	structure	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	LOX-1	lox-1	NN	NN	_	3	nmod	_	_
6	resembles	resemble	VBZ	VBZ	_	0	root	_	_
7	that	that	DT	DT	_	6	xcomp	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	natural	natural	JJ	JJ	_	13	amod	_	_
11	killer	killer	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Fluorescence	fluorescence	NN	NN	_	4	compound	_	_
2	in	in	FW	FW	_	4	amod	_	_
3	situ	situ	FW	FW	_	2	dep	_	_
4	hybridization	hybridization	NN	NN	_	13	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	analyses	analysis	NNS	NNS	_	4	conj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	yeast	yeast	NN	NN	_	12	compound	_	_
10	artificial	artificial	JJ	JJ	_	12	amod	_	_
11	chromosome	chromosome	NN	NN	_	12	compound	_	_
12	contig	contig	NN	NN	_	6	nmod	_	_
13	revealed	reveal	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	20	mark	_	_
15	the	the	DT	DT	_	18	det	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	LOX-1	lox-1	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	located	located	JJ	JJ	_	13	ccomp	_	_
21	in	in	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	natural	natural	JJ	JJ	_	26	amod	_	_
24	killer	killer	NN	NN	_	26	compound	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	complex	complex	NN	NN	_	20	nmod	_	_
27	on	on	IN	IN	_	29	case	_	_
28	chromosome	chromosome	NN	NN	_	29	compound	_	_
29	12p12-p13	12p12-p13	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	where	where	WRB	WRB	_	40	advmod	_	_
32	the	the	DT	DT	_	33	det	_	_
33	genes	gene	NNS	NNS	_	40	nsubj	_	_
34	of	of	IN	IN	_	39	case	_	_
35	the	the	DT	DT	_	39	det	_	_
36	natural	natural	JJ	JJ	_	39	amod	_	_
37	killer	killer	NN	NN	_	39	compound	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	receptors	receptor	NNS	NNS	_	33	nmod	_	_
40	cluster	cluster	VBP	VBP	_	29	acl:relcl	_	_
41	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	expression	expression	NN	NN	_	6	compound	_	_
6	pattern	pattern	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	LOX-1	lox-1	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	different	different	JJ	JJ	_	0	root	_	_
11	from	from	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	natural	natural	JJ	JJ	_	18	amod	_	_
16	killer	killer	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	receptors	receptor	NNS	NNS	_	12	nmod	_	_
19	;	;	:	:	_	10	punct	_	_
20	LOX-1	lox-1	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	10	parataxis	_	_
23	in	in	IN	IN	_	25	case	_	_
24	vascular-rich	vascular-rich	JJ	JJ	_	25	amod	_	_
25	organs	organ	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	25	cc	_	_
29	in	in	IN	IN	_	30	case	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	25	conj	_	_
31	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	1753-bp	1753-bp	JJ	JJ	_	3	amod	_	_
3	fragment	fragment	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	5'	5'	JJ	JJ	_	8	amod	_	_
7	flanking	flanking	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	LOX-1	lox-1	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	had	have	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	functional	functional	JJ	JJ	_	17	amod	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	several	several	JJ	JJ	_	9	amod	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	STAT	stat	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	NF-IL6	nf-il6	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	3	punct	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	24	nsubjpass	_	_
21	of	of	IN	IN	_	22	case	_	_
22	LOX-1	lox-1	NN	NN	_	20	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	upregulated	upregulate	VBN	VBN	_	3	conj	_	_
25	by	by	IN	IN	_	27	case	_	_
26	several	several	JJ	JJ	_	27	amod	_	_
27	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	LOX-1	lox-1	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	member	member	NN	NN	_	3	ccomp	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	natural	natural	JJ	JJ	_	18	amod	_	_
16	killer	killer	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	12	nmod	_	_
19	with	with	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	unique	unique	JJ	JJ	_	23	amod	_	_
22	expression	expression	NN	NN	_	23	compound	_	_
23	profile	profile	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Cloning	cloning	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	ARE-containing	are-containing	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	AU-motif-directed	au-motif-directed	JJ	JJ	_	7	amod	_	_
7	display	display	NN	NN	_	1	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	procedure	procedure	NN	NN	_	13	nsubjpass	_	_
3	suitable	suitable	JJ	JJ	_	2	amod	_	_
4	for	for	IN	IN	_	7	case	_	_
5	cloning	clone	VBG	VBG	_	7	amod	_	_
6	labile	labile	JJ	JJ	_	7	amod	_	_
7	mRNAs	mrna	NNS	NNS	_	3	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	contain	contain	VBP	VBP	_	7	acl:relcl	_	_
10	AU	au	NN	NN	_	11	compound	_	_
11	motifs	motif	NNS	NNS	_	9	dobj	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	presented	present	VBN	VBN	_	0	root	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	AU-DD	au-dd	NN	NN	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	motifs	motif	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	sequences	sequence	NNS	NNS	_	0	root	_	_
6	within	within	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	so-called	so-called	JJ	JJ	_	10	amod	_	_
9	AU-rich	au-rich	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	AREs	are	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	often	often	RB	RB	_	15	advmod	_	_
15	found	find	VBN	VBN	_	10	acl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	3'	3'	JJ	JJ	_	19	amod	_	_
18	untranslated	untranslated	JJ	JJ	_	19	amod	_	_
19	regions	region	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	genes	gene	NNS	NNS	_	19	nmod	_	_
22	such	such	JJ	JJ	_	24	case	_	_
23	as	as	IN	IN	_	22	mwe	_	_
24	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	proto-oncogenes	proto-oncogene	NNS	NNS	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	24	conj	_	_
31	.	.	.	.	_	5	punct	_	_

1	AU-DD	au-dd	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	an	a	DT	DT	_	6	det	_	_
4	AU-motif-directed	au-motif-directed	JJ	JJ	_	6	amod	_	_
5	differential	differential	JJ	JJ	_	6	amod	_	_
6	display	display	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	permits	permit	VBZ	VBZ	_	6	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	identification	identification	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	ARE-containing	are-containing	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	differentially	differentially	RB	RB	_	15	advmod	_	_
15	expressed	express	VBN	VBN	_	13	acl	_	_
16	after	after	IN	IN	_	18	case	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	applied	apply	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	clone	clone	NN	NN	_	8	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	isolate	isolate	VB	VB	_	4	xcomp	_	_
16	59	59	CD	CD	_	18	nummod	_	_
17	cDNA	cdna	NN	NN	_	18	compound	_	_
18	fragments	fragment	NNS	NNS	_	15	dobj	_	_
19	associated	associate	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	activation	activation	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Fourteen	fourteen	CD	CD	_	2	nummod	_	_
2	percent	percent	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	isolated	isolate	VBN	VBN	_	5	amod	_	_
5	fragments	fragment	NNS	NNS	_	2	nmod	_	_
6	belong	belong	VBP	VBP	_	0	root	_	_
7	to	to	TO	TO	_	10	case	_	_
8	already	already	RB	RB	_	9	advmod	_	_
9	known	known	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	14	nsubj	_	_
12	certainly	certainly	RB	RB	_	14	advmod	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	cytokines	cytokine	NNS	NNS	_	10	acl:relcl	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	transduction/transcription	transduction/transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	remaining	remain	VBG	VBG	_	4	amod	_	_
3	86	86	CD	CD	_	4	nummod	_	_
4	%	%	NN	NN	_	5	nsubj	_	_
5	correspond	correspond	VBP	VBP	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	unknown	unknown	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	15	nmod	_	_
11	92	92	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	15	nsubjpass	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	confirmed	confirm	VBN	VBN	_	8	acl:relcl	_	_
16	to	to	TO	TO	_	19	mark	_	_
17	be	be	VB	VB	_	19	auxpass	_	_
18	differentially	differentially	RB	RB	_	19	advmod	_	_
19	expressed	express	VBN	VBN	_	15	xcomp	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	efficiency	efficiency	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	system	system	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	support	support	VBP	VBP	_	3	conj	_	_
11	the	the	DT	DT	_	12	det	_	_
12	notion	notion	NN	NN	_	10	dobj	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	numerous	numerous	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	20	nsubj	_	_
16	falling	fall	VBG	VBG	_	15	acl	_	_
17	into	into	IN	IN	_	19	case	_	_
18	those	those	DT	DT	_	19	det	_	_
19	categories	category	NNS	NNS	_	16	nmod	_	_
20	remain	remain	VBP	VBP	_	12	ccomp	_	_
21	unidentified	unidentified	JJ	JJ	_	20	xcomp	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	they	they	PRP	PRP	_	27	nsubjpass	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	cloned	clone	VBN	VBN	_	20	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	this	this	DT	DT	_	30	det	_	_
30	method	method	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	receptor	receptor	NN	NN	_	1	conj	_	_
5	.	.	.	.	_	1	punct	_	_

1	Thrombopoietin	thrombopoietin	NN	NN	_	16	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	TPO	tpo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	physiological	physiological	JJ	JJ	_	9	amod	_	_
9	regulator	regulator	NN	NN	_	1	appos	_	_
10	of	of	IN	IN	_	12	case	_	_
11	platelet	platelet	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	1	punct	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	initially	initially	RB	RB	_	16	advmod	_	_
16	thought	think	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	21	mark	_	_
18	be	be	VB	VB	_	21	cop	_	_
19	a	a	DT	DT	_	21	det	_	_
20	lineage-specific	lineage-specific	JJ	JJ	_	21	amod	_	_
21	factor	factor	NN	NN	_	16	xcomp	_	_
22	acting	act	VBG	VBG	_	21	acl	_	_
23	predominantly	predominantly	RB	RB	_	22	advmod	_	_
24	on	on	IN	IN	_	25	case	_	_
25	megakaryocytopoiesis	megakaryocytopoiesis	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	Detailed	detailed	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	cytokine	cytokine	NN	NN	_	7	nsubj	_	_
7	mediates	mediate	VBZ	VBZ	_	3	ccomp	_	_
8	biological	biological	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	7	dobj	_	_
10	on	on	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	broad	broad	JJ	JJ	_	13	amod	_	_
13	spectrum	spectrum	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	hematopoietic	hematopoietic	JJ	JJ	_	17	amod	_	_
16	progenitor	progenitor	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	including	include	VBG	VBG	_	21	case	_	_
20	stem	stem	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	TPO	tpo	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	hormone	hormone	NN	NN	_	0	root	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	produced	produce	VBN	VBN	_	4	acl	_	_
7	mainly	mainly	RB	RB	_	10	advmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	liver	liver	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	kidney	kidney	NN	NN	_	10	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Plasma	plasma	NN	NN	_	3	compound	_	_
2	TPO	tpo	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	regulated	regulate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	platelet	platelet	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	megakaryocyte	megakaryocyte	NN	NN	_	8	conj	_	_
11	mass	mass	NN	NN	_	5	nmod	_	_
12	through	through	IN	IN	_	14	case	_	_
13	Mpl	mpl	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	5	nmod	_	_
15	binding	binding	NN	NN	_	14	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	internalization	internalization	NN	NN	_	15	conj	_	_
18	and	and	CC	CC	_	15	cc	_	_
19	degradation	degradation	NN	NN	_	15	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Mpl	mpl	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	member	member	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	hematopoietin	hematopoietin	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	superfamily	superfamily	NN	NN	_	6	nmod	_	_
12	lacking	lack	VBG	VBG	_	11	acl	_	_
13	intrinsic	intrinsic	JJ	JJ	_	15	amod	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	6	punct	_	_

1	Upon	upon	IN	IN	_	4	case	_	_
2	ligand-induced	ligand-induced	JJ	JJ	_	4	amod	_	_
3	Mpl	mpl	NN	NN	_	4	compound	_	_
4	homodimerization	homodimerization	NN	NN	_	13	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	major	major	JJ	JJ	_	9	amod	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	events	event	NNS	NNS	_	13	nsubjpass	_	_
10	for	for	IN	IN	_	11	case	_	_
11	proliferation	proliferation	NN	NN	_	9	nmod	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	0	root	_	_
14	through	through	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	JAK2/STAT5	jak2/stat5	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	while	while	IN	IN	_	22	mark	_	_
20	differentiation	differentiation	NN	NN	_	22	nsubj	_	_
21	might	might	MD	MD	_	22	aux	_	_
22	occur	occur	VB	VB	_	13	advcl	_	_
23	through	through	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	prolonged	prolonged	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	MAPK	mapk	NN	NN	_	30	compound	_	_
30	pathway	pathway	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	13	punct	_	_

1	Preclinical	preclinical	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	clinical	clinical	JJ	JJ	_	1	conj	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	potential	potential	JJ	JJ	_	8	amod	_	_
8	use	use	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	TPO	tpo	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	variety	variety	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	contexts	context	NNS	NNS	_	13	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	but	but	CC	CC	_	5	cc	_	_
18	it	it	PRP	PRP	_	21	nsubj	_	_
19	is	be	VBZ	VBZ	_	21	cop	_	_
20	too	too	RB	RB	_	21	advmod	_	_
21	early	early	JJ	JJ	_	5	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	evaluate	evaluate	VB	VB	_	21	xcomp	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	benefit	benefit	NN	NN	_	23	dobj	_	_
26	in	in	IN	IN	_	27	mark	_	_
27	reducing	reduce	VBG	VBG	_	25	acl	_	_
28	platelet	platelet	NN	NN	_	29	compound	_	_
29	transfusion	transfusion	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	5	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	distinct	distinct	JJ	JJ	_	7	amod	_	_
6	STAT5	stat5	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	2	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	IL-5	il-5	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	GM-CSF	gm-csf	NN	NN	_	9	conj	_	_
12	during	during	IN	IN	_	16	case	_	_
13	eosinophil	eosinophil	NN	NN	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	neutrophil	neutrophil	NN	NN	_	13	conj	_	_
16	differentiation	differentiation	NN	NN	_	2	nmod	_	_
17	from	from	IN	IN	_	22	case	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	CD34+	cd34+	JJ	JJ	_	22	amod	_	_
20	hematopoietic	hematopoietic	JJ	JJ	_	22	amod	_	_
21	stem	stem	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Interleukin-5	interleukin-5	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-5	il-5	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	granulocyte	granulocyte	NN	NN	_	9	compound	_	_
7	macrophage-colony	macrophage-colony	NN	NN	_	9	compound	_	_
8	stimulating	stimulating	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	1	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GM-CSF	gm-csf	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	proliferation	proliferation	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	differentiation	differentiation	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	activation	activation	NN	NN	_	18	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
26	lineages	lineage	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	JAK/STAT	jak/stat	NN	NN	_	3	compound	_	_
3	pathway	pathway	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	one	one	CD	CD	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	5	nmod	_	_
10	implicated	implicate	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	mediating	mediate	VBG	VBG	_	10	advcl	_	_
13	biological	biological	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	12	dobj	_	_
15	induced	induce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cytokines	cytokine	NNS	NNS	_	9	nsubj	_	_
8	predominantly	predominantly	RB	RB	_	9	advmod	_	_
9	activate	activate	VBP	VBP	_	4	ccomp	_	_
10	an	a	DT	DT	_	14	det	_	_
11	80	80	CD	CD	_	14	nummod	_	_
12	kDa	kda	NN	NN	_	14	compound	_	_
13	STAT5	stat5	NN	NN	_	14	compound	_	_
14	isoform	isoform	NN	NN	_	9	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	mature	mature	JJ	JJ	_	17	amod	_	_
17	granulocytes	granulocyte	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	17	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT	stat	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	during	during	IN	IN	_	10	case	_	_
10	growth	growth	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	differentiation	differentiation	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	granulocytes	granulocyte	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	evaluated	evaluate	VBD	VBD	_	0	root	_	_
18	differentiation	differentiation	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	human	human	JJ	JJ	_	24	amod	_	_
21	CD34+	cd34+	JJ	JJ	_	24	amod	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	24	amod	_	_
23	stem	stem	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	18	nmod	_	_
25	ex	ex	FW	FW	_	26	compound	_	_
26	vivo	vivo	FW	FW	_	18	advmod	_	_
27	toward	toward	IN	IN	_	28	case	_	_
28	eosinophils	eosinophil	NNS	NNS	_	18	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	neutrophils	neutrophil	NNS	NNS	_	28	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	Bandshift	bandshift	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	early	early	JJ	JJ	_	8	amod	_	_
8	stage	stage	NN	NN	_	24	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	both	both	DT	DT	_	12	det	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	14	14	CD	CD	_	15	nummod	_	_
15	days	day	NNS	NNS	_	8	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	24	punct	_	_
18	the	the	DT	DT	_	22	det	_	_
19	94	94	CD	CD	_	20	compound	_	_
20	kDa	kda	NN	NN	_	22	amod	_	_
21	STAT5B	stat5b	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	activated	activate	VBN	VBN	_	3	ccomp	_	_
25	by	by	IN	IN	_	27	case	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	IL-5	il-5	NN	NN	_	24	nmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	eosinophil	eosinophil	NN	NN	_	30	compound	_	_
30	lineage	lineage	NN	NN	_	27	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	GM-CSF	gm-csf	NN	NN	_	27	conj	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	neutrophil	neutrophil	NN	NN	_	36	compound	_	_
36	lineage	lineage	NN	NN	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	26	advmod	_	_
2	,	,	,	,	_	26	punct	_	_
3	during	during	IN	IN	_	4	case	_	_
4	maturation	maturation	NN	NN	_	26	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	both	both	DT	DT	_	7	det	_	_
7	lineages	lineage	NNS	NNS	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	days	day	NNS	NNS	_	4	appos	_	_
10	21	21	CD	CD	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	28	28	CD	CD	_	10	conj	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	,	,	,	,	_	26	punct	_	_
15	increased	increase	VBN	VBN	_	16	amod	_	_
16	expression	expression	NN	NN	_	26	nsubjpass	_	_
17	of	of	IN	IN	_	24	case	_	_
18	a	a	DT	DT	_	24	det	_	_
19	functionally	functionally	RB	RB	_	20	advmod	_	_
20	distinct	distinct	JJ	JJ	_	24	amod	_	_
21	80	80	CD	CD	_	24	nummod	_	_
22	kDa	kda	NN	NN	_	24	compound	_	_
23	STAT5	stat5	NN	NN	_	24	compound	_	_
24	isoform	isoform	NN	NN	_	16	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	observed	observe	VBN	VBN	_	0	root	_	_
27	,	,	,	,	_	26	punct	_	_
28	resulting	result	VBG	VBG	_	26	xcomp	_	_
29	in	in	IN	IN	_	32	case	_	_
30	heterodimer	heterodimer	NN	NN	_	32	compound	_	_
31	DNA-binding	dna-binding	JJ	JJ	_	32	amod	_	_
32	complexes	complex	NNS	NNS	_	28	nmod	_	_
33	containing	contain	VBG	VBG	_	32	acl	_	_
34	both	both	CC	CC	_	41	dep	_	_
35	the	the	DT	DT	_	41	det	_	_
36	94	94	CD	CD	_	39	compound	_	_
37	and	and	CC	CC	_	39	cc	_	_
38	80	80	CD	CD	_	39	conj	_	_
39	kDa	kda	NN	NN	_	41	amod	_	_
40	STAT5	stat5	NN	NN	_	41	compound	_	_
41	proteins	protein	NNS	NNS	_	33	dobj	_	_
42	.	.	.	.	_	26	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	20	nsubj	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	distinct	distinct	JJ	JJ	_	6	amod	_	_
6	isoforms	isoform	NNS	NNS	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT5	stat5	NN	NN	_	6	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	activated	activate	VBN	VBN	_	2	ccomp	_	_
11	during	during	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	det	_	_
13	early	early	JJ	JJ	_	17	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	late	late	JJ	JJ	_	13	conj	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	stages	stage	NNS	NNS	_	10	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	granulocytes	granulocyte	NNS	NNS	_	17	nmod	_	_
20	suggests	suggest	VBZ	VBZ	_	0	root	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	they	they	PRP	PRP	_	25	nsubjpass	_	_
23	might	might	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	involved	involve	VBN	VBN	_	20	ccomp	_	_
26	in	in	IN	IN	_	27	mark	_	_
27	regulating	regulate	VBG	VBG	_	25	advcl	_	_
28	different	different	JJ	JJ	_	30	amod	_	_
29	biological	biological	JJ	JJ	_	30	amod	_	_
30	functions	function	NNS	NNS	_	27	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	these	these	DT	DT	_	33	det	_	_
33	cells	cell	NNS	NNS	_	27	nmod	_	_
34	.	.	.	.	_	20	punct	_	_

1	BASH	bash	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	signaling	signal	VBG	VBG	_	6	amod	_	_
6	molecule	molecule	NN	NN	_	1	appos	_	_
7	preferentially	preferentially	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	bursa	bursa	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Fabricius	fabricius	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	bursa	bursa	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Fabricius	fabricius	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	gut-associated	gut-associated	JJ	JJ	_	9	amod	_	_
8	lymphoid	lymphoid	JJ	JJ	_	9	amod	_	_
9	organ	organ	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	essential	essential	JJ	JJ	_	9	acl:relcl	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	generation	generation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	diversified	diversified	JJ	JJ	_	21	amod	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	repertoire	repertoire	NN	NN	_	15	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	chicken	chicken	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	gene	gene	NN	NN	_	2	dobj	_	_
7	preferentially	preferentially	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	6	acl	_	_
9	in	in	IN	IN	_	12	case	_	_
10	bursal	bursal	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	gene	gene	NN	NN	_	3	nsubj	_	_
3	encodes	encode	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	85-kDa	85-kda	JJ	JJ	_	6	amod	_	_
6	protein	protein	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	designated	designate	VBN	VBN	_	6	acl	_	_
9	BASH	bash	NN	NN	_	8	xcomp	_	_
10	(	(	-LRB-	-LRB-	_	16	punct	_	_
11	B	b	NN	NN	_	16	compound	_	_
12	cell	cell	NN	NN	_	16	compound	_	_
13	adaptor	adaptor	NN	NN	_	16	compound	_	_
14	containing	contain	VBG	VBG	_	16	amod	_	_
15	SH2	sh2	NN	NN	_	16	compound	_	_
16	domain	domain	NN	NN	_	9	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	6	punct	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	contains	contain	VBZ	VBZ	_	6	acl:relcl	_	_
21	N-terminal	n-terminal	JJ	JJ	_	23	amod	_	_
22	acidic	acidic	JJ	JJ	_	23	amod	_	_
23	domains	domain	NNS	NNS	_	20	dobj	_	_
24	with	with	IN	IN	_	28	case	_	_
25	SH2	sh2	NN	NN	_	28	compound	_	_
26	domain-binding	domain-binding	JJ	JJ	_	28	amod	_	_
27	phosphotyrosine-based	phosphotyrosine-based	JJ	JJ	_	28	amod	_	_
28	motifs	motif	NNS	NNS	_	23	nmod	_	_
29	,	,	,	,	_	23	punct	_	_
30	a	a	DT	DT	_	32	det	_	_
31	proline-rich	proline-rich	JJ	JJ	_	32	amod	_	_
32	domain	domain	NN	NN	_	23	conj	_	_
33	,	,	,	,	_	23	punct	_	_
34	and	and	CC	CC	_	23	cc	_	_
35	a	a	DT	DT	_	38	det	_	_
36	C-terminal	c-terminal	JJ	JJ	_	38	amod	_	_
37	SH2	sh2	NN	NN	_	38	compound	_	_
38	domain	domain	NN	NN	_	23	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	BASH	bash	NN	NN	_	2	nsubj	_	_
2	shows	show	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	substantial	substantial	JJ	JJ	_	6	amod	_	_
5	sequence	sequence	NN	NN	_	6	compound	_	_
6	similarity	similarity	NN	NN	_	2	dobj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	SLP-76	slp-76	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	an	a	DT	DT	_	12	det	_	_
11	adaptor	adaptor	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	8	appos	_	_
13	functioning	function	VBG	VBG	_	12	acl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	TCR-signal	tcr-signal	JJ	JJ	_	16	amod	_	_
16	transduction	transduction	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	BASH	bash	NN	NN	_	2	nsubj	_	_
2	becomes	become	VBZ	VBZ	_	0	root	_	_
3	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	2	xcomp	_	_
4	with	with	IN	IN	_	13	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	B	b	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	Ag	ag	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	BCR	bcr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	cross-link	cross-link	NN	NN	_	2	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	by	by	IN	IN	_	16	case	_	_
16	coexpression	coexpression	NN	NN	_	13	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	Syk	syk	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	Lyn	lyn	NN	NN	_	18	conj	_	_
21	and	and	CC	CC	_	2	cc	_	_
22	associates	associate	VBZ	VBZ	_	2	conj	_	_
23	with	with	IN	IN	_	25	case	_	_
24	signaling	signal	VBG	VBG	_	25	amod	_	_
25	molecules	molecule	NNS	NNS	_	22	nmod	_	_
26	including	include	VBG	VBG	_	27	case	_	_
27	Syk	syk	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	a	a	DT	DT	_	33	det	_	_
30	putative	putative	JJ	JJ	_	33	amod	_	_
31	chicken	chicken	NN	NN	_	33	compound	_	_
32	Shc	shc	NN	NN	_	33	compound	_	_
33	homologue	homologue	NN	NN	_	27	conj	_	_
34	.	.	.	.	_	2	punct	_	_

1	Overexpression	overexpression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	BASH	bash	NN	NN	_	1	nmod	_	_
4	results	result	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	suppression	suppression	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	NF-AT	nf-at	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	BCR-cross-linking	bcr-cross-linking	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	BASH	bash	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	BCR-mediated	bcr-mediated	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	could	could	MD	MD	_	14	aux	_	_
14	play	play	VB	VB	_	7	conj	_	_
15	a	a	DT	DT	_	17	det	_	_
16	critical	critical	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	development	development	NN	NN	_	14	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	bursa	bursa	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Signaling	signaling	NN	NN	_	2	compound	_	_
2	pathways	pathway	NNS	NNS	_	10	nsubj	_	_
3	mediated	mediate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	TNF-	tnf-	NN	NN	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	cytokine-receptor	cytokine-receptor	JJ	JJ	_	6	conj	_	_
9	families	family	NNS	NNS	_	3	nmod	_	_
10	target	target	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	common	common	JJ	JJ	_	13	amod	_	_
13	cis-element	cis-element	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	IFN	ifn	NN	NN	_	20	compound	_	_
17	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
18	factor	factor	NN	NN	_	20	compound	_	_
19	1	1	CD	CD	_	20	nummod	_	_
20	promoter	promoter	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	strongly	strongly	RB	RB	_	8	advmod	_	_
8	influenced	influence	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	presence	presence	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	16	nsubjpass	_	_
6	for	for	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interplay	interplay	NN	NN	_	5	nmod	_	_
9	between	between	IN	IN	_	12	case	_	_
10	these	these	DT	DT	_	12	det	_	_
11	distinct	distinct	JJ	JJ	_	12	amod	_	_
12	stimuli	stimulus	NNS	NNS	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	16	auxpass	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	clearly	clearly	RB	RB	_	16	advmod	_	_
16	delineated	delineate	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	IFN	ifn	NN	NN	_	3	compound	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	11	nsubj	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IRF-1	irf-1	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	0	root	_	_
12	activated	activate	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	either	either	CC	CC	_	15	cc:preconj	_	_
15	CD40	cd40	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	cytokines	cytokine	NNS	NNS	_	15	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	these	these	DT	DT	_	7	det	_	_
6	different	different	JJ	JJ	_	7	amod	_	_
7	sets	set	NNS	NNS	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	signals	signal	NNS	NNS	_	7	nmod	_	_
10	target	target	VBP	VBP	_	3	ccomp	_	_
11	a	a	DT	DT	_	14	det	_	_
12	common	common	JJ	JJ	_	14	amod	_	_
13	cis-acting	cis-acting	JJ	JJ	_	14	amod	_	_
14	element	element	NN	NN	_	10	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	promoter	promoter	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	gene	gene	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	the	the	DT	DT	_	25	det	_	_
23	IRF-1	irf-1	NN	NN	_	25	compound	_	_
24	gamma-activated	gamma-activated	JJ	JJ	_	25	amod	_	_
25	site	site	NN	NN	_	20	appos	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	GAS	gas	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	3	punct	_	_

1	Targeting	targeting	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	IRF-1	irf-1	NN	NN	_	5	compound	_	_
5	GAS	gas	NN	NN	_	1	nmod	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	confined	confine	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	via	via	IN	IN	_	12	case	_	_
12	CD40	cd40	NN	NN	_	10	nmod	_	_
13	but	but	CC	CC	_	8	cc	_	_
14	extends	extend	VBZ	VBZ	_	8	conj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	stimuli	stimulus	NNS	NNS	_	14	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	mimic	mimic	VBP	VBP	_	17	acl:relcl	_	_
20	the	the	DT	DT	_	23	det	_	_
21	CD40	cd40	NN	NN	_	23	compound	_	_
22	signaling	signaling	NN	NN	_	23	compound	_	_
23	cascade	cascade	NN	NN	_	19	dobj	_	_
24	,	,	,	,	_	17	punct	_	_
25	like	like	IN	IN	_	26	case	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	17	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	EBV	ebv	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	contrast	contrast	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	induction	induction	NN	NN	_	22	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STATs	stats	NNS	NNS	_	4	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	22	punct	_	_
10	the	the	DT	DT	_	13	det	_	_
11	IRF-1	irf-1	NN	NN	_	12	nmod:npmod	_	_
12	GAS-binding	gas-binding	JJ	JJ	_	13	amod	_	_
13	complex	complex	NN	NN	_	22	nsubj	_	_
14	activated	activate	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	CD40	cd40	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	EBV	ebv	NN	NN	_	16	conj	_	_
22	contains	contain	VBZ	VBZ	_	0	root	_	_
23	Rel	rel	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	22	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	specifically	specifically	RB	RB	_	27	advmod	_	_
27	p50	p50	NN	NN	_	24	appos	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	p65	p65	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	system	system	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	simultaneous	simultaneous	JJ	JJ	_	6	amod	_	_
6	exposure	exposure	NN	NN	_	17	nsubj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	CD40L	cd40l	NN	NN	_	6	nmod	_	_
9	together	together	RB	RB	_	12	advmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	IL-4	il-4	NN	NN	_	6	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	conj	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	lead	lead	VB	VB	_	0	root	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	novel	novel	JJ	JJ	_	24	amod	_	_
23	Rel/STAT	rel/stat	NN	NN	_	24	compound	_	_
24	complexes	complex	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	Given	give	VBN	VBN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	importance	importance	NN	NN	_	19	nmod	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IRF-1	irf-1	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	variety	variety	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	biologic	biologic	JJ	JJ	_	11	amod	_	_
11	functions	function	NNS	NNS	_	8	nmod	_	_
12	from	from	IN	IN	_	13	case	_	_
13	proliferation	proliferation	NN	NN	_	8	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	our	we	PRP$	PRP$	_	18	nmod:poss	_	_
18	findings	finding	NNS	NNS	_	19	nsubj	_	_
19	support	support	VBP	VBP	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	notion	notion	NN	NN	_	19	dobj	_	_
22	that	that	IN	IN	_	32	mark	_	_
23	modulation	modulation	NN	NN	_	32	nsubj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	IRF-1	irf-1	NN	NN	_	26	compound	_	_
26	levels	level	NNS	NNS	_	23	nmod	_	_
27	may	may	MD	MD	_	32	aux	_	_
28	be	be	VB	VB	_	32	cop	_	_
29	a	a	DT	DT	_	32	det	_	_
30	critical	critical	JJ	JJ	_	32	amod	_	_
31	control	control	NN	NN	_	32	compound	_	_
32	point	point	NN	NN	_	21	ccomp	_	_
33	in	in	IN	IN	_	36	case	_	_
34	B	b	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	19	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
4	B	b	NN	NN	_	8	compound	_	_
5	,	,	,	,	_	8	punct	_	_
6	AP-1	ap-1	NN	NN	_	8	dep	_	_
7	,	,	,	,	_	8	punct	_	_
8	NFAT	nfat	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	STAT1	stat1	NN	NN	_	13	compound	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	import	import	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	noninvasive	noninvasive	JJ	JJ	_	19	amod	_	_
19	delivery	delivery	NN	NN	_	1	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	peptide	peptide	NN	NN	_	19	nmod	_	_
22	carrying	carry	VBG	VBG	_	21	acl	_	_
23	the	the	DT	DT	_	26	det	_	_
24	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
25	localization	localization	NN	NN	_	26	compound	_	_
26	sequence	sequence	NN	NN	_	22	dobj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	NF-kappa	nf-kappa	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	p50	p50	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	Ags	ag	NNS	NNS	_	1	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	cytokines	cytokine	NNS	NNS	_	6	conj	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	translocation	translocation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	NF-kappa	nf-kappa	NN	NN	_	17	compound	_	_
17	B	b	NN	NN	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	AP-1	ap-1	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	NFAT	nfat	NN	NN	_	17	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	STAT	stat	NN	NN	_	17	conj	_	_
25	from	from	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	cytoplasm	cytoplasm	NN	NN	_	11	nmod	_	_
28	into	into	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	11	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	step	step	NN	NN	_	10	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	import	import	NN	NN	_	8	compound	_	_
8	process	process	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	recognition	recognition	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	localization	localization	NN	NN	_	15	compound	_	_
15	sequence	sequence	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	NLS	nls	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	within	within	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	karyophilic	karyophilic	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	15	nmod	_	_
23	by	by	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	cytoplasmic	cytoplasmic	JJ	JJ	_	26	amod	_	_
26	receptor	receptor	NN	NN	_	15	nmod	_	_
27	such	such	JJ	JJ	_	35	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	the	the	DT	DT	_	35	det	_	_
30	importin	importin	NN	NN	_	35	compound	_	_
31	(	(	-LRB-	-LRB-	_	35	punct	_	_
32	karyopherin	karyopherin	NN	NN	_	35	compound	_	_
33	)	)	-RRB-	-RRB-	_	35	punct	_	_
34	-alpha	-alpha	NN	NN	_	35	compound	_	_
35	subunit	subunit	NN	NN	_	26	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	NLSs	nlss	NNS	NNS	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	AP-1	ap-1	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	NFAT	nfat	NN	NN	_	5	conj	_	_
11	differ	differ	VBP	VBP	_	0	root	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	NLS	nls	NN	NN	_	21	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	STAT1	stat1	NN	NN	_	14	nmod	_	_
17	has	have	VBZ	VBZ	_	21	aux	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	yet	yet	RB	RB	_	21	advmod	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	identified	identify	VBN	VBN	_	11	conj	_	_
22	.	.	.	.	_	11	punct	_	_

1	Herein	herein	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	25	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	inducible	inducible	JJ	JJ	_	8	amod	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	import	import	NN	NN	_	25	nsubjpass	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	B	b	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	AP-1	ap-1	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	NFAT	nfat	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	STAT1	stat1	NN	NN	_	11	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	Jurkat	jurkat	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	significantly	significantly	RB	RB	_	25	advmod	_	_
25	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
26	by	by	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	cell-permeable	cell-permeable	JJ	JJ	_	29	amod	_	_
29	peptide	peptide	NN	NN	_	25	nmod	_	_
30	carrying	carry	VBG	VBG	_	29	acl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	NLS	nls	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
36	B	b	NN	NN	_	38	compound	_	_
37	p50	p50	NN	NN	_	38	compound	_	_
38	subunit	subunit	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	NLS	nls	NN	NN	_	2	nmod:npmod	_	_
2	peptide-mediated	peptide-mediated	JJ	JJ	_	3	amod	_	_
3	disruption	disruption	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	import	import	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	these	these	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	inhibition	inhibition	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	I	i	NN	NN	_	19	compound	_	_
17	kappa	kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	alpha	alpha	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	IL-2	il-2	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	14	conj	_	_
24	,	,	,	,	_	14	punct	_	_
25	processes	process	NNS	NNS	_	14	appos	_	_
26	dependent	dependent	JJ	JJ	_	25	amod	_	_
27	on	on	IN	IN	_	29	case	_	_
28	NF-kappa	nf-kappa	NN	NN	_	29	compound	_	_
29	B	b	NN	NN	_	26	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	32	det	_	_
32	combination	combination	NN	NN	_	29	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	NF-kappa	nf-kappa	NN	NN	_	35	compound	_	_
35	B	b	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	AP-1	ap-1	NN	NN	_	35	conj	_	_
38	,	,	,	,	_	35	punct	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	NFAT	nfat	NN	NN	_	35	conj	_	_
41	.	.	.	.	_	12	punct	_	_

1	Further	further	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	inhibitory	inhibitory	JJ	JJ	_	8	amod	_	_
7	NLS	nls	NN	NN	_	8	compound	_	_
8	peptide	peptide	NN	NN	_	9	nsubj	_	_
9	interacts	interact	VBZ	VBZ	_	4	ccomp	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	with	with	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	cytoplasmic	cytoplasmic	JJ	JJ	_	17	amod	_	_
15	NLS	nls	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	9	nmod	_	_
18	comprised	comprise	VBN	VBN	_	17	acl	_	_
19	of	of	IN	IN	_	26	case	_	_
20	the	the	DT	DT	_	26	det	_	_
21	Rch1/importin	rch1/importin	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	karyopherin	karyopherin	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	-beta	-beta	NN	NN	_	26	compound	_	_
26	heterodimer	heterodimer	NN	NN	_	18	nmod	_	_
27	expressed	express	VBN	VBN	_	26	acl	_	_
28	in	in	IN	IN	_	31	case	_	_
29	Jurkat	jurkat	NN	NN	_	31	compound	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	28	mark	_	_
8	the	the	DT	DT	_	11	det	_	_
9	inducible	inducible	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	import	import	NN	NN	_	28	nsubjpass	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	AP-1	ap-1	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	NFAT	nfat	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	STAT1	stat1	NN	NN	_	14	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	Jurkat	jurkat	NN	NN	_	25	compound	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	11	nmod	_	_
26	can	can	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	regulated	regulate	VBN	VBN	_	6	ccomp	_	_
29	by	by	IN	IN	_	31	case	_	_
30	NLS	nls	NN	NN	_	31	compound	_	_
31	peptide	peptide	NN	NN	_	28	nmod	_	_
32	delivered	deliver	VBN	VBN	_	31	acl	_	_
33	noninvasively	noninvasively	RB	RB	_	32	advmod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	cytoplasm	cytoplasm	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	Jurkat	jurkat	NN	NN	_	40	compound	_	_
39	T	t	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	36	nmod	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	target	target	NN	NN	_	32	xcomp	_	_
43	members	member	NNS	NNS	_	42	dobj	_	_
44	of	of	IN	IN	_	54	case	_	_
45	the	the	DT	DT	_	54	det	_	_
46	importin	importin	NN	NN	_	54	compound	_	_
47	(	(	-LRB-	-LRB-	_	54	punct	_	_
48	karyopherin	karyopherin	NN	NN	_	54	compound	_	_
49	)	)	-RRB-	-RRB-	_	54	punct	_	_
50	-alpha	-alpha	NN	NN	_	54	compound	_	_
51	beta	beta	NN	NN	_	54	compound	_	_
52	NLS	nls	NN	NN	_	54	compound	_	_
53	receptor	receptor	NN	NN	_	54	compound	_	_
54	complex	complex	NN	NN	_	43	nmod	_	_
55	.	.	.	.	_	6	punct	_	_

1	Epithelial	epithelial	JJ	JJ	_	2	amod	_	_
2	cell-initiated	cell-initiated	JJ	JJ	_	3	amod	_	_
3	inflammation	inflammation	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	crucial	crucial	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	early	early	JJ	JJ	_	11	amod	_	_
10	tissue	tissue	NN	NN	_	11	compound	_	_
11	damage	damage	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	amebic	amebic	JJ	JJ	_	14	amod	_	_
14	infection	infection	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	intestine	intestine	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	&amp;	&amp;	CC	CC	_	1	cc	_	_
3	AIMS	aim	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Entamoeba	entamoeba	FW	FW	_	7	compound	_	_
6	histolytica	histolytica	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	intestine	intestine	NN	NN	_	7	nmod	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	induce	induce	VB	VB	_	1	dep	_	_
13	severe	severe	JJ	JJ	_	15	amod	_	_
14	gut	gut	NN	NN	_	15	compound	_	_
15	inflammation	inflammation	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aims	aim	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	assess	assess	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	host	host	NN	NN	_	15	compound	_	_
14	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	10	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	tissue	tissue	NN	NN	_	19	compound	_	_
19	damage	damage	NN	NN	_	10	nmod	_	_
20	observed	observe	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	amebiasis	amebiasis	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	role	role	NN	NN	_	10	conj	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	intestinal	intestinal	JJ	JJ	_	30	amod	_	_
29	epithelial	epithelial	JJ	JJ	_	30	amod	_	_
30	cell	cell	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	32	mark	_	_
32	initiating	initiate	VBG	VBG	_	25	acl	_	_
33	that	that	DT	DT	_	34	det	_	_
34	response	response	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	6	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	E.	e.	FW	FW	_	5	compound	_	_
4	histolytica	histolytica	NN	NN	_	5	compound	_	_
5	infection	infection	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	established	establish	VBN	VBN	_	1	appos	_	_
8	in	in	IN	IN	_	19	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	intestinal	intestinal	JJ	JJ	_	11	amod	_	_
11	xenografts	xenograft	NNS	NNS	_	19	compound	_	_
12	in	in	IN	IN	_	15	case	_	_
13	severe	severe	JJ	JJ	_	15	amod	_	_
14	combined	combined	JJ	JJ	_	15	amod	_	_
15	immunodeficient	immunodeficient	JJ	JJ	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	SCID-HU-INT	scid-hu-int	JJ	JJ	_	11	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	mice	mouse	NNS	NNS	_	7	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	intestinal	intestinal	JJ	JJ	_	6	amod	_	_
3	epithelial	epithelial	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	inflammatory	inflammatory	JJ	JJ	_	6	amod	_	_
6	responses	response	NNS	NNS	_	11	nsubjpass	_	_
7	to	to	TO	TO	_	9	case	_	_
8	amebic	amebic	JJ	JJ	_	9	amod	_	_
9	infection	infection	NN	NN	_	6	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	intraluminal	intraluminal	JJ	JJ	_	15	amod	_	_
15	administration	administration	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	antisense	antisense	JJ	JJ	_	19	amod	_	_
19	oligonucleotide	oligonucleotide	NN	NN	_	15	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	p65	p65	NN	NN	_	24	compound	_	_
24	subunit	subunit	NN	NN	_	15	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
27	factor	factor	NN	NN	_	28	compound	_	_
28	kappaB	kappab	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	11	punct	_	_
30	and	and	CC	CC	_	11	cc	_	_
31	the	the	DT	DT	_	32	det	_	_
32	role	role	NN	NN	_	42	nsubjpass	_	_
33	of	of	IN	IN	_	34	case	_	_
34	neutrophils	neutrophil	NNS	NNS	_	32	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	tissue	tissue	NN	NN	_	37	compound	_	_
37	damage	damage	NN	NN	_	32	nmod	_	_
38	observed	observe	VBN	VBN	_	37	acl	_	_
39	with	with	IN	IN	_	40	case	_	_
40	amebiasis	amebiasis	NN	NN	_	38	nmod	_	_
41	was	be	VBD	VBD	_	42	auxpass	_	_
42	studied	study	VBN	VBN	_	11	conj	_	_
43	by	by	IN	IN	_	44	mark	_	_
44	depleting	deplete	VBG	VBG	_	42	advcl	_	_
45	neutrophils	neutrophil	NNS	NNS	_	44	dobj	_	_
46	from	from	IN	IN	_	48	case	_	_
47	SCID-HU-INT	scid-hu-int	JJ	JJ	_	48	amod	_	_
48	mice	mouse	NNS	NNS	_	44	nmod	_	_
49	.	.	.	.	_	11	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Administration	administration	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	antisense	antisense	JJ	JJ	_	7	amod	_	_
7	oligonucleotide	oligonucleotide	NN	NN	_	3	nmod	_	_
8	blocked	block	VBD	VBD	_	1	appos	_	_
9	the	the	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	interleukin	interleukin	NN	NN	_	14	compound	_	_
14	1beta	1beta	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	interleukin	interleukin	NN	NN	_	14	conj	_	_
17	8	8	CD	CD	_	16	nummod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	intestinal	intestinal	JJ	JJ	_	21	amod	_	_
20	epithelial	epithelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	10	nmod	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	inhibited	inhibit	VBD	VBD	_	8	conj	_	_
24	neutrophil	neutrophil	NN	NN	_	25	compound	_	_
25	influx	influx	NN	NN	_	23	dobj	_	_
26	into	into	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	E.	e.	FW	FW	_	29	dep	_	_
29	histolytica-infected	histolytica-infected	JJ	JJ	_	31	amod	_	_
30	intestinal	intestinal	JJ	JJ	_	31	amod	_	_
31	xenografts	xenograft	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	Inhibition	inhibition	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	gut	gut	NN	NN	_	6	compound	_	_
5	inflammatory	inflammatory	JJ	JJ	_	6	amod	_	_
6	response	response	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	antisense	antisense	JJ	JJ	_	10	amod	_	_
10	oligonucleotide	oligonucleotide	NN	NN	_	1	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	depletion	depletion	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	neutrophils	neutrophil	NNS	NNS	_	13	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	SCID-HU-INT	scid-hu-int	JJ	JJ	_	18	amod	_	_
18	mice	mouse	NNS	NNS	_	13	nmod	_	_
19	blocked	block	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	intestinal	intestinal	JJ	JJ	_	24	amod	_	_
24	permeability	permeability	NN	NN	_	21	nmod	_	_
25	observed	observe	VBN	VBN	_	24	acl	_	_
26	with	with	IN	IN	_	28	case	_	_
27	amebic	amebic	JJ	JJ	_	28	amod	_	_
28	infection	infection	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	19	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Intestinal	intestinal	JJ	JJ	_	5	amod	_	_
4	epithelial	epithelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	initiate	initiate	VBP	VBP	_	1	appos	_	_
7	an	a	DT	DT	_	9	det	_	_
8	inflammatory	inflammatory	JJ	JJ	_	9	amod	_	_
9	response	response	NN	NN	_	6	dobj	_	_
10	with	with	IN	IN	_	6	dep	_	_
11	resulting	result	VBG	VBG	_	14	amod	_	_
12	neutrophil-mediated	neutrophil-mediated	JJ	JJ	_	14	amod	_	_
13	tissue	tissue	NN	NN	_	14	compound	_	_
14	damage	damage	NN	NN	_	6	dobj	_	_
15	in	in	IN	IN	_	20	case	_	_
16	response	response	NN	NN	_	20	dep	_	_
17	to	to	TO	TO	_	20	case	_	_
18	E.	e.	FW	FW	_	20	compound	_	_
19	histolytica	histolytica	NN	NN	_	20	compound	_	_
20	infection	infection	NN	NN	_	6	nmod	_	_
21	;	;	:	:	_	1	punct	_	_
22	this	this	DT	DT	_	24	det	_	_
23	inflammatory	inflammatory	JJ	JJ	_	24	amod	_	_
24	cascade	cascade	NN	NN	_	27	nsubjpass	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	blocked	block	VBN	VBN	_	1	dep	_	_
28	by	by	IN	IN	_	29	mark	_	_
29	inhibiting	inhibit	VBG	VBG	_	27	advcl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	transcription	transcription	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	genes	gene	NNS	NNS	_	31	nmod	_	_
34	regulated	regulate	VBN	VBN	_	33	acl	_	_
35	by	by	IN	IN	_	38	case	_	_
36	nuclear	nuclear	JJ	JJ	_	38	amod	_	_
37	factor	factor	NN	NN	_	38	compound	_	_
38	kappaB	kappab	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	1	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	suppression	suppression	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	programmed	program	VBN	VBN	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	death	death	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	tissue	tissue	NN	NN	_	13	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	3	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	metalloproteinases-1	metalloproteinases-1	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	pathways	pathway	NNS	NNS	_	14	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	induction	induction	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	programmed	program	VBN	VBN	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	death	death	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PCD	pcd	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	have	have	VBP	VBP	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	but	but	CC	CC	_	14	cc	_	_
17	little	little	JJ	JJ	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	known	know	VBN	VBN	_	14	conj	_	_
20	about	about	IN	IN	_	24	case	_	_
21	specific	specific	JJ	JJ	_	24	amod	_	_
22	extracellular	extracellular	JJ	JJ	_	24	amod	_	_
23	matrix	matrix	NN	NN	_	24	compound	_	_
24	processes	process	NNS	NNS	_	19	nmod	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	may	may	MD	MD	_	27	aux	_	_
27	affect	affect	VB	VB	_	24	acl:relcl	_	_
28	apoptosis	apoptosis	NN	NN	_	27	dobj	_	_
29	along	along	IN	IN	_	31	case	_	_
30	those	those	DT	DT	_	31	det	_	_
31	pathways	pathway	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	17	nmod	_	_
4	,	,	,	,	_	17	punct	_	_
5	a	a	DT	DT	_	6	det	_	_
6	series	series	NN	NN	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	15	case	_	_
8	Burkitt	burkitt	NN	NN	_	15	nmod:poss	_	_
9	's	's	POS	POS	_	15	case	_	_
10	lymphoma	lymphoma	NN	NN	_	15	compound	_	_
11	(	(	-LRB-	-LRB-	_	15	punct	_	_
12	BL	bl	NN	NN	_	15	compound	_	_
13	)	)	-RRB-	-RRB-	_	15	punct	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	6	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	assayed	assay	VBN	VBN	_	0	root	_	_
18	for	for	IN	IN	_	20	case	_	_
19	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
20	expression	expression	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	27	case	_	_
22	tissue	tissue	NN	NN	_	27	compound	_	_
23	inhibitor	inhibitor	NN	NN	_	27	compound	_	_
24	of	of	IN	IN	_	27	amod	_	_
25	metalloproteinases	metalloproteinase	NNS	NNS	_	27	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	TIMP	timp	NNS	NNS	_	20	nmod	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	-1	-1	CD	CD	_	27	nummod	_	_
30	.	.	.	.	_	17	punct	_	_

1	Results	result	NNS	NNS	_	2	nsubj	_	_
2	indicate	indicate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	TIMP-1-positive	timp-1-positive	JJ	JJ	_	6	amod	_	_
5	BL	bl	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	7	nsubj	_	_
7	show	show	VBP	VBP	_	2	ccomp	_	_
8	resistance	resistance	NN	NN	_	7	dobj	_	_
9	to	to	TO	TO	_	11	case	_	_
10	cold-shock-induced	cold-shock-induced	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	recombinant	recombinant	JJ	JJ	_	4	amod	_	_
4	TIMP-1	timp-1	NN	NN	_	18	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	but	but	CC	CC	_	7	cc	_	_
7	not	not	RB	RB	_	4	cc	_	_
8	TIMP-2	timp-2	NN	NN	_	4	conj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	synthetic	synthetic	JJ	JJ	_	13	amod	_	_
12	metalloproteinase	metalloproteinase	NN	NN	_	13	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	8	conj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	BB-94	bb-94	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	4	punct	_	_
18	confers	confer	VBZ	VBZ	_	0	root	_	_
19	resistance	resistance	NN	NN	_	18	dobj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
22	induced	induce	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	38	case	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	CD95-dependent	cd95-dependent	JJ	JJ	_	38	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	-independent	-independent	JJ	JJ	_	25	conj	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	cold	cold	JJ	JJ	_	30	amod	_	_
30	shock	shock	NN	NN	_	38	dep	_	_
31	,	,	,	,	_	30	punct	_	_
32	serum	serum	NN	NN	_	33	compound	_	_
33	deprivation	deprivation	NN	NN	_	30	conj	_	_
34	,	,	,	,	_	30	punct	_	_
35	and	and	CC	CC	_	30	cc	_	_
36	gamma-radiation	gamma-radiation	NN	NN	_	30	conj	_	_
37	)	)	-RRB-	-RRB-	_	30	punct	_	_
38	pathways	pathway	NNS	NNS	_	22	nmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	TIMP-1-negative	timp-1-negative	JJ	JJ	_	42	amod	_	_
41	BL	bl	NN	NN	_	42	compound	_	_
42	lines	line	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	18	punct	_	_

1	TIMP-1	timp-1	NN	NN	_	2	compound	_	_
2	suppression	suppression	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PCD	pcd	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	10	cop	_	_
6	not	not	RB	RB	_	10	neg	_	_
7	due	due	JJ	JJ	_	10	case	_	_
8	to	to	TO	TO	_	7	mwe	_	_
9	metalloproteinase	metalloproteinase	NN	NN	_	10	compound	_	_
10	inhibition	inhibition	NN	NN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	as	as	IN	IN	_	21	mark	_	_
13	reduction	reduction	NN	NN	_	21	nsubj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	alkylation	alkylation	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	TIMP-1	timp-1	NN	NN	_	13	nmod	_	_
19	did	do	VBD	VBD	_	21	aux	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	abolish	abolish	VB	VB	_	10	dep	_	_
22	this	this	DT	DT	_	23	det	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	10	punct	_	_

1	Retroviral	retroviral	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TIMP-1	timp-1	NN	NN	_	2	nmod	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	only	only	RB	RB	_	7	dep	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	survival	survival	NN	NN	_	7	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	also	also	RB	RB	_	16	advmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	continued	continued	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	synthesis	synthesis	NN	NN	_	10	conj	_	_
17	for	for	IN	IN	_	21	case	_	_
18	up	up	RB	RB	_	20	advmod	_	_
19	to	to	TO	TO	_	20	dep	_	_
20	5	5	CD	CD	_	21	nummod	_	_
21	d	d	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	dep	_	_
24	absence	absence	NN	NN	_	26	dep	_	_
25	of	of	IN	IN	_	26	case	_	_
26	serum	serum	NN	NN	_	7	nmod	_	_
27	,	,	,	,	_	7	punct	_	_
28	while	while	IN	IN	_	30	mark	_	_
29	controls	control	NNS	NNS	_	30	nsubj	_	_
30	underwent	undergo	VBD	VBD	_	7	advcl	_	_
31	apoptosis	apoptosis	NN	NN	_	30	dobj	_	_
32	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	resistance	resistance	NN	NN	_	6	nsubjpass	_	_
3	to	to	TO	TO	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	reversed	reverse	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	anti-TIMP-1	anti-timp-1	JJ	JJ	_	9	amod	_	_
9	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	demonstrating	demonstrate	VBG	VBG	_	6	xcomp	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	secreted	secrete	VBN	VBN	_	14	amod	_	_
14	TIMP-1	timp-1	NN	NN	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	active	active	JJ	JJ	_	11	ccomp	_	_
17	in	in	IN	IN	_	18	mark	_	_
18	blocking	block	VBG	VBG	_	16	advcl	_	_
19	apoptosis	apoptosis	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	TIMP-1	timp-1	NN	NN	_	4	compound	_	_
4	upregulation	upregulation	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Bcl-XL	bcl-xl	NN	NN	_	6	nmod	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	Bcl-2	bcl-2	NN	NN	_	8	conj	_	_
12	as	as	RB	RB	_	5	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	decreased	decrease	VBN	VBN	_	5	conj	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	15	dobj	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	compared	compare	VBN	VBN	_	15	advcl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	controls	control	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TIMP-1	timp-1	NN	NN	_	6	nsubj	_	_
6	suppresses	suppress	VBZ	VBZ	_	3	ccomp	_	_
7	apoptosis	apoptosis	NN	NN	_	6	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	suggests	suggest	VBZ	VBZ	_	6	conj	_	_
13	a	a	DT	DT	_	15	det	_	_
14	novel	novel	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	TIMP-1	timp-1	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	tissue	tissue	NN	NN	_	20	compound	_	_
20	homeostasis	homeostasis	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Interleukin-12	interleukin-12	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	transformation	transformation	NN	NN	_	2	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	Epstein-Barr	epstein-barr	JJ	JJ	_	10	amod	_	_
10	virus	virus	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	interleukin	interleukin	NN	NN	_	4	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL	il	NN	NN	_	9	nsubjpass	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	-12	-12	CD	CD	_	4	nummod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	originally	originally	RB	RB	_	9	advmod	_	_
9	purified	purify	VBN	VBN	_	37	advcl	_	_
10	from	from	IN	IN	_	19	case	_	_
11	an	a	DT	DT	_	19	det	_	_
12	Epstein-Barr	epstein-barr	JJ	JJ	_	19	amod	_	_
13	(	(	-LRB-	-LRB-	_	19	punct	_	_
14	EBV	ebv	NN	NN	_	19	compound	_	_
15	)	)	-RRB-	-RRB-	_	19	punct	_	_
16	-transformed	-transformed	JJ	JJ	_	19	amod	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	line	line	NN	NN	_	9	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	high	high	JJ	JJ	_	23	amod	_	_
23	correlation	correlation	NN	NN	_	32	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	EBV	ebv	NN	NN	_	26	compound	_	_
26	infection	infection	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	IL-12	il-12	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	conj	_	_
30	has	have	VBZ	VBZ	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	suggested	suggest	VBN	VBN	_	9	conj	_	_
33	,	,	,	,	_	37	punct	_	_
34	no	no	DT	DT	_	35	neg	_	_
35	study	study	NN	NN	_	37	nsubj	_	_
36	has	have	VBZ	VBZ	_	37	aux	_	_
37	reported	report	VBN	VBN	_	0	root	_	_
38	whether	whether	IN	IN	_	43	mark	_	_
39	EBV	ebv	NN	NN	_	40	compound	_	_
40	infection	infection	NN	NN	_	43	nsubjpass	_	_
41	is	be	VBZ	VBZ	_	43	auxpass	_	_
42	directly	directly	RB	RB	_	43	advmod	_	_
43	linked	link	VBN	VBN	_	37	ccomp	_	_
44	to	to	TO	TO	_	46	case	_	_
45	IL-12	il-12	NN	NN	_	46	compound	_	_
46	expression	expression	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	37	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	8	advcl	_	_
3	this	this	DT	DT	_	4	det	_	_
4	issue	issue	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	IL-12	il-12	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	during	during	IN	IN	_	17	case	_	_
15	in	in	FW	FW	_	17	amod	_	_
16	vitro	vitro	FW	FW	_	15	dep	_	_
17	transformation	transformation	NN	NN	_	10	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	EBV	ebv	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	peripheral	peripheral	JJ	JJ	_	4	amod	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	became	become	VBD	VBD	_	0	root	_	_
6	capable	capable	JJ	JJ	_	5	xcomp	_	_
7	of	of	IN	IN	_	9	mark	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	producing	produce	VBG	VBG	_	6	advcl	_	_
10	p40	p40	NN	NN	_	9	dobj	_	_
11	by	by	IN	IN	_	14	case	_	_
12	in	in	FW	FW	_	14	amod	_	_
13	vitro	vitro	FW	FW	_	12	dep	_	_
14	transformation	transformation	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	EBV	ebv	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	coincident	coincident	JJ	JJ	_	5	xcomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	latent	latent	JJ	JJ	_	25	amod	_	_
24	membrane	membrane	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	LMP1	lmp1	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	of	of	IN	IN	_	31	case	_	_
31	EBV	ebv	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	expressed	express	VBD	VBD	_	0	root	_	_
5	p40	p40	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p35	p35	NN	NN	_	5	conj	_	_
8	mRNA	mrna	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	phorbol	phorbol	NN	NN	_	13	compound	_	_
12	myristate	myristate	NN	NN	_	13	compound	_	_
13	acetate	acetate	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PMA	pma	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	stimulation	stimulation	NN	NN	_	19	nsubj	_	_
18	strongly	strongly	RB	RB	_	19	advmod	_	_
19	enhanced	enhance	VBD	VBD	_	4	conj	_	_
20	p40	p40	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	p70	p70	NN	NN	_	20	conj	_	_
23	production	production	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	transfection	transfection	NN	NN	_	18	nsubj	_	_
4	with	with	IN	IN	_	7	case	_	_
5	LMP1	lmp1	NN	NN	_	7	compound	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	vector	vector	NN	NN	_	3	nmod	_	_
8	into	into	IN	IN	_	14	case	_	_
9	a	a	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	lymphoma	lymphoma	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	3	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	Daudi	daudi	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	14	punct	_	_
18	led	lead	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	21	case	_	_
20	p40	p40	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	nmod	_	_
22	with	with	IN	IN	_	29	case	_	_
23	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
24	factor	factor	NN	NN	_	29	compound	_	_
25	(	(	-LRB-	-LRB-	_	29	punct	_	_
26	NF	nf	NN	NN	_	29	compound	_	_
27	)	)	-RRB-	-RRB-	_	29	punct	_	_
28	-kappaB	-kappab	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	18	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	transformation	transformation	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	EBV	ebv	NN	NN	_	5	nmod	_	_
12	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
13	IL-12	il-12	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	potentially	potentially	RB	RB	_	12	advmod	_	_
16	through	through	IN	IN	_	18	case	_	_
17	LMP1	lmp1	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Conserved	conserve	VBN	VBN	_	2	amod	_	_
2	elements	element	NNS	NNS	_	11	nsubjpass	_	_
3	containing	contain	VBG	VBG	_	2	acl	_	_
4	NF-E2	nf-e2	NN	NN	_	9	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	tandem	tandem	JJ	JJ	_	4	conj	_	_
7	GATA	gata	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	3	dobj	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	16	case	_	_
13	erythroid-specific	erythroid-specific	JJ	JJ	_	16	amod	_	_
14	chromatin	chromatin	NN	NN	_	16	compound	_	_
15	structure	structure	NN	NN	_	16	compound	_	_
16	reorganization	reorganization	NN	NN	_	11	nmod	_	_
17	within	within	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	human	human	JJ	JJ	_	23	amod	_	_
20	beta-globin	beta-globin	NN	NN	_	23	compound	_	_
21	locus	locus	NN	NN	_	23	compound	_	_
22	control	control	NN	NN	_	23	compound	_	_
23	region	region	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	Proper	proper	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	beta-globin	beta-globin	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	locus	locus	NN	NN	_	5	nmod	_	_
12	requires	require	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	17	det	_	_
14	associated	associate	VBN	VBN	_	17	amod	_	_
15	locus	locus	NN	NN	_	17	compound	_	_
16	control	control	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	12	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	LCR	lcr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	12	punct	_	_

1	Structurally	structurally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	LCR	lcr	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	defined	define	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	presence	presence	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	four	four	CD	CD	_	12	nummod	_	_
12	domains	domain	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	erythroid-specific	erythroid-specific	JJ	JJ	_	16	amod	_	_
15	chromatin	chromatin	NN	NN	_	16	compound	_	_
16	structure	structure	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	domains	domain	NNS	NNS	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	characterized	characterize	VBN	VBN	_	2	acl:relcl	_	_
8	as	as	IN	IN	_	12	case	_	_
9	DNase	dnase	NN	NN	_	12	compound	_	_
10	I	i	CD	CD	_	12	nummod	_	_
11	hypersensitive	hypersensitive	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HSs	hss	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	2	punct	_	_
17	comprise	comprise	VBP	VBP	_	0	root	_	_
18	the	the	DT	DT	_	20	det	_	_
19	active	active	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	17	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	LCR	lcr	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	major	major	JJ	JJ	_	3	amod	_	_
3	focus	focus	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	research	research	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	define	define	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cis-acting	cis-acting	JJ	JJ	_	12	amod	_	_
12	elements	element	NNS	NNS	_	9	dobj	_	_
13	which	which	WDT	WDT	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	required	require	VBN	VBN	_	12	acl:relcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	formation	formation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	domains	domain	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	unique	unique	JJ	JJ	_	25	amod	_	_
24	chromatin	chromatin	NN	NN	_	25	compound	_	_
25	structure	structure	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	investigations	investigation	NNS	NNS	_	10	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	formation	formation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	LCR	lcr	NN	NN	_	9	compound	_	_
9	HS4	hs4	NN	NN	_	6	nmod	_	_
10	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	21	mark	_	_
12	NF-E2	nf-e2	NN	NN	_	19	compound	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	tandem	tandem	JJ	JJ	_	12	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	inverted	inverted	JJ	JJ	_	14	dep	_	_
17	GATA	gata	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	sites	site	NNS	NNS	_	21	nsubjpass	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	required	require	VBN	VBN	_	10	ccomp	_	_
22	for	for	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	formation	formation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	native	native	JJ	JJ	_	28	amod	_	_
28	HS	hs	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	Similarly	similarly	RB	RB	_	2	advmod	_	_
2	arranged	arrange	VBN	VBN	_	3	amod	_	_
3	NF-E2	nf-e2	NN	NN	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tandem	tandem	JJ	JJ	_	7	amod	_	_
6	GATA	gata	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	3	conj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	present	present	JJ	JJ	_	0	root	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	core	core	NN	NN	_	13	compound	_	_
13	regions	region	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	other	other	JJ	JJ	_	19	amod	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	LCR	lcr	NN	NN	_	19	compound	_	_
19	HSs	hss	NNS	NNS	_	13	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	are	be	VBP	VBP	_	23	auxpass	_	_
22	evolutionarily	evolutionarily	RB	RB	_	23	advmod	_	_
23	conserved	conserve	VBN	VBN	_	9	conj	_	_
24	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	12	dep	_	_
2	site-directed	site-directed	JJ	JJ	_	3	amod	_	_
3	mutagenesis	mutagenesis	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	HSs	hss	NNS	NNS	_	3	nmod	_	_
7	2	2	CD	CD	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	3	3	CD	CD	_	7	conj	_	_
10	we	we	PRP	PRP	_	12	nsubj	_	_
11	have	have	VBP	VBP	_	12	aux	_	_
12	tested	test	VBN	VBN	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	hypothesis	hypothesis	NN	NN	_	12	dobj	_	_
15	that	that	IN	IN	_	23	mark	_	_
16	these	these	DT	DT	_	20	det	_	_
17	NF-E2	nf-e2	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	GATA	gata	NN	NN	_	17	conj	_	_
20	sites	site	NNS	NNS	_	23	nsubj	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	common	common	JJ	JJ	_	23	amod	_	_
23	requirements	requirement	NNS	NNS	_	14	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	formation	formation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	all	all	DT	DT	_	30	det	_	_
29	LCR	lcr	NN	NN	_	30	compound	_	_
30	HSs	hss	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	mutation	mutation	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	elements	element	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	particularly	particularly	RB	RB	_	13	advmod	_	_
11	the	the	DT	DT	_	13	det	_	_
12	GATA	gata	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	7	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	results	result	VBZ	VBZ	_	2	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	decrease	decrease	NN	NN	_	15	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	complete	complete	JJ	JJ	_	21	amod	_	_
21	loss	loss	NN	NN	_	18	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	DNase	dnase	NN	NN	_	25	compound	_	_
24	I	i	CD	CD	_	25	nummod	_	_
25	hypersensitivity	hypersensitivity	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	common	common	JJ	JJ	_	9	amod	_	_
8	structural	structural	JJ	JJ	_	9	amod	_	_
9	elements	element	NNS	NNS	_	5	nmod	_	_
10	within	within	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	core	core	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	each	each	DT	DT	_	16	det	_	_
15	LCR	lcr	NN	NN	_	16	compound	_	_
16	HS	hs	NN	NN	_	12	nmod	_	_
17	which	which	WDT	WDT	_	19	nsubjpass	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	required	require	VBN	VBN	_	9	acl:relcl	_	_
20	for	for	IN	IN	_	24	case	_	_
21	erythroid-specific	erythroid-specific	JJ	JJ	_	24	amod	_	_
22	chromatin	chromatin	NN	NN	_	24	compound	_	_
23	structure	structure	NN	NN	_	24	compound	_	_
24	reorganization	reorganization	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Anaphylatoxins	anaphylatoxin	NNS	NNS	_	5	nsubj	_	_
2	C5a	c5a	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	C3a	c3a	NN	NN	_	2	conj	_	_
5	induce	induce	VBP	VBP	_	0	root	_	_
6	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	kappaB	kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	anaphylatoxins	anaphylatoxin	NNS	NNS	_	7	nsubjpass	_	_
3	C5a	c5a	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	C3a	c3a	NN	NN	_	3	conj	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	16	nmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	capability	capability	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	C5a	c5a	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	C3a	c3a	NN	NN	_	7	conj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	5	acl	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	dobj	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	C5a	c5a	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	C3a	c3a	NN	NN	_	1	conj	_	_
4	stimulation	stimulation	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
8	blood	blood	NN	NN	_	9	compound	_	_
9	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
10	resulted	result	VBD	VBD	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	13	nmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	specificity	specificity	NN	NN	_	13	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	kappaB	kappab	NN	NN	_	24	compound	_	_
24	sequence	sequence	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	p50	p50	NN	NN	_	5	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	p65	p65	NN	NN	_	2	conj	_	_
5	proteins	protein	NNS	NNS	_	16	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	constituents	constituent	NNS	NNS	_	5	appos	_	_
8	of	of	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	prototypic	prototypic	JJ	JJ	_	13	amod	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	factor	factor	NN	NN	_	13	compound	_	_
13	kappaB	kappab	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	0	root	_	_
17	as	as	IN	IN	_	18	case	_	_
18	components	component	NNS	NNS	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	DNA-protein	dna-protein	JJ	JJ	_	22	amod	_	_
22	complexes	complex	NNS	NNS	_	18	nmod	_	_
23	by	by	IN	IN	_	25	case	_	_
24	anti-peptide	anti-peptide	JJ	JJ	_	25	amod	_	_
25	antibodies	antibody	NNS	NNS	_	16	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	gel	gel	NN	NN	_	29	compound	_	_
28	supershift	supershift	NN	NN	_	29	compound	_	_
29	assays	assay	NNS	NNS	_	16	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	C5a	c5a	NN	NN	_	2	nmod:npmod	_	_
2	induced	induced	JJ	JJ	_	5	amod	_	_
3	kappaB	kappab	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	15	15	CD	CD	_	9	nummod	_	_
9	min	min	NN	NN	_	7	nmod	_	_
10	after	after	IN	IN	_	9	case	_	_
11	agonist	agonist	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	9	dep	_	_
13	,	,	,	,	_	7	punct	_	_
14	peaked	peak	VBD	VBD	_	7	conj	_	_
15	at	at	IN	IN	_	17	case	_	_
16	30-40	30-40	CD	CD	_	17	nummod	_	_
17	min	min	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	remained	remain	VBD	VBD	_	7	conj	_	_
21	detectable	detectable	JJ	JJ	_	20	xcomp	_	_
22	at	at	IN	IN	_	24	case	_	_
23	2	2	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	7	punct	_	_

1	Binding	binding	NN	NN	_	6	nsubjpass	_	_
2	to	to	TO	TO	_	4	case	_	_
3	kappaB	kappab	NN	NN	_	4	compound	_	_
4	sequence	sequence	NN	NN	_	1	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	accompanied	accompany	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	an	a	DT	DT	_	10	det	_	_
9	initial	initial	JJ	JJ	_	10	amod	_	_
10	decrease	decrease	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	subsequent	subsequent	JJ	JJ	_	13	amod	_	_
13	increase	increase	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	18	amod	_	_
17	IkappaBalpha	ikappabalpha	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	10	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	as	as	IN	IN	_	21	mark	_	_
21	detected	detect	VBN	VBN	_	6	advcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	Western	western	NN	NN	_	24	compound	_	_
24	blotting	blotting	NN	NN	_	21	nmod	_	_
25	using	use	VBG	VBG	_	24	acl	_	_
26	an	a	DT	DT	_	28	det	_	_
27	anti-IkappaBalpha	anti-ikappabalpha	JJ	JJ	_	28	amod	_	_
28	antibody	antibody	NN	NN	_	25	dobj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Pertussis	pertussis	NN	NN	_	3	compound	_	_
2	toxin	toxin	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	5	nsubj	_	_
4	markedly	markedly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBD	VBD	_	0	root	_	_
6	kappaB	kappab	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activities	activity	NNS	NNS	_	5	dobj	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	C5a	c5a	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	C3a	c3a	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	whereas	whereas	IN	IN	_	19	mark	_	_
17	cholera	cholera	NN	NN	_	18	compound	_	_
18	toxin	toxin	NN	NN	_	19	nsubj	_	_
19	displayed	display	VBD	VBD	_	5	advcl	_	_
20	no	no	DT	DT	_	22	neg	_	_
21	inhibitory	inhibitory	JJ	JJ	_	22	amod	_	_
22	effect	effect	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Neither	neither	DT	DT	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	toxins	toxin	NNS	NNS	_	1	nmod	_	_
6	affected	affect	VBD	VBD	_	0	root	_	_
7	kappaB	kappab	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	induced	induce	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	TNFalpha	tnfalpha	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	same	same	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	anaphylatoxins	anaphylatoxin	NNS	NNS	_	6	nmod	_	_
10	C5a	c5a	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	C3a	c3a	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	regulating	regulate	VBG	VBG	_	6	acl	_	_
15	leukocytes	leukocyte	NNS	NNS	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	through	through	IN	IN	_	23	case	_	_
19	G	g	NN	NN	_	20	nmod:npmod	_	_
20	protein-coupled	protein-coupled	JJ	JJ	_	23	amod	_	_
21	transcription	transcription	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Tpl-2	tpl-2	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	IL-2	il-2	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	triggering	trigger	VBG	VBG	_	2	advcl	_	_
10	multiple	multiple	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	9	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	activate	activate	VBP	VBP	_	12	acl:relcl	_	_
15	NFAT	nfat	NN	NN	_	14	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tpl-2	tpl-2	NN	NN	_	3	compound	_	_
3	kinase	kinase	NN	NN	_	4	nsubj	_	_
4	activates	activate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	11	det	_	_
6	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
7	factor	factor	NN	NN	_	11	compound	_	_
8	of	of	IN	IN	_	11	amod	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NFAT	nfat	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	4	cc	_	_
16	induces	induce	VBZ	VBZ	_	4	conj	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	Tpl-2	tpl-2	NN	NN	_	6	nmod	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	inhibited	inhibit	VBN	VBN	_	3	ccomp	_	_
15	by	by	IN	IN	_	18	case	_	_
16	mutant	mutant	JJ	JJ	_	18	amod	_	_
17	signaling	signal	VBG	VBG	_	18	amod	_	_
18	molecules	molecule	NNS	NNS	_	14	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	inhibit	inhibit	VBP	VBP	_	18	acl:relcl	_	_
21	the	the	DT	DT	_	24	det	_	_
22	mitogen-activated	mitogen-activated	JJ	JJ	_	24	amod	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	kinase	kinase	NN	NN	_	20	dobj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	MAPK	mapk	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	or	or	CC	CC	_	24	cc	_	_
29	the	the	DT	DT	_	31	det	_	_
30	calcineurin/NFAT	calcineurin/nfat	NN	NN	_	31	compound	_	_
31	pathways	pathway	NNS	NNS	_	24	conj	_	_
32	and	and	CC	CC	_	14	cc	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	promoted	promote	VBN	VBN	_	14	conj	_	_
35	by	by	IN	IN	_	36	case	_	_
36	combinations	combination	NNS	NNS	_	34	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	signaling	signal	VBG	VBG	_	39	amod	_	_
39	molecules	molecule	NNS	NNS	_	36	nmod	_	_
40	that	that	WDT	WDT	_	41	nsubj	_	_
41	activate	activate	VBP	VBP	_	39	acl:relcl	_	_
42	these	these	DT	DT	_	43	det	_	_
43	pathways	pathway	NNS	NNS	_	41	dobj	_	_
44	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	5	nsubj	_	_
2	,	,	,	,	_	5	punct	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	,	,	,	,	_	5	punct	_	_
5	conclude	conclude	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	20	mark	_	_
7	signals	signal	NNS	NNS	_	20	nsubj	_	_
8	generated	generate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	convergence	convergence	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	MAPK	mapk	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	calcineurin/NFAT	calcineurin/nfat	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	11	conj	_	_
19	are	be	VBP	VBP	_	20	cop	_	_
20	necessary	necessary	JJ	JJ	_	5	ccomp	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	sufficient	sufficient	JJ	JJ	_	20	conj	_	_
23	for	for	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	activation	activation	NN	NN	_	20	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	Tpl-2	tpl-2	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	both	both	CC	CC	_	7	cc:preconj	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	an	a	DT	DT	_	12	det	_	_
10	NFAT-driven	nfat-driven	JJ	JJ	_	12	amod	_	_
11	minimal	minimal	JJ	JJ	_	12	amod	_	_
12	promoter	promoter	NN	NN	_	7	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	depend	depend	VB	VB	_	14	xcomp	_	_
17	on	on	IN	IN	_	18	case	_	_
18	signals	signal	NNS	NNS	_	16	nmod	_	_
19	transduced	transduce	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	21	case	_	_
21	Raf1	raf1	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	it	it	PRP	PRP	_	8	nsubj	_	_
4	was	be	VBD	VBD	_	8	cop	_	_
5	only	only	RB	RB	_	8	advmod	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IL-2	il-2	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	0	root	_	_
9	whose	whose	WP$	WP$	_	10	nmod:poss	_	_
10	activation	activation	NN	NN	_	15	nsubjpass	_	_
11	by	by	IN	IN	_	12	case	_	_
12	Tpl-2	tpl-2	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	fully	fully	RB	RB	_	15	advmod	_	_
15	blocked	block	VBN	VBN	_	8	dep	_	_
16	by	by	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	dominant	dominant	JJ	JJ	_	21	amod	_	_
19	negative	negative	JJ	JJ	_	21	amod	_	_
20	mutant	mutant	JJ	JJ	_	21	amod	_	_
21	MEK1S218/222A	mek1s218/222a	NN	NN	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	MEK1/MEK2	mek1/mek2	NN	NN	_	26	compound	_	_
25	inhibitor	inhibitor	NN	NN	_	26	compound	_	_
26	PD098059	pd098059	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	8	punct	_	_

1	Since	since	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	activation	activation	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NFAT	nfat	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	MAPK-dependent	mapk-dependent	JJ	JJ	_	10	advcl	_	_
8	these	these	DT	DT	_	9	det	_	_
9	findings	finding	NNS	NNS	_	10	nsubj	_	_
10	suggested	suggest	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	20	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activation	activation	NN	NN	_	20	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	MAPK	mapk	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	Tpl-2	tpl-2	NN	NN	_	13	nmod	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	either	either	CC	CC	_	20	cc:preconj	_	_
20	independent	independent	JJ	JJ	_	10	ccomp	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	only	only	RB	RB	_	23	advmod	_	_
23	partially	partially	RB	RB	_	24	advmod	_	_
24	dependent	dependent	JJ	JJ	_	20	conj	_	_
25	on	on	IN	IN	_	26	case	_	_
26	MEK1	mek1	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	MEK2	mek2	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	they	they	PRP	PRP	_	5	nsubj	_	_
5	suggested	suggest	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	under	under	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	control	control	NN	NN	_	5	ccomp	_	_
17	of	of	IN	IN	_	20	case	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	only	only	RB	RB	_	20	cc:preconj	_	_
20	NFAT	nfat	NN	NN	_	16	nmod	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	also	also	RB	RB	_	25	advmod	_	_
23	a	a	DT	DT	_	25	det	_	_
24	second	second	JJ	JJ	_	25	amod	_	_
25	factor	factor	NN	NN	_	20	conj	_	_
26	whose	whose	WP$	WP$	_	27	nmod:poss	_	_
27	activation	activation	NN	NN	_	29	nsubj	_	_
28	is	be	VBZ	VBZ	_	29	cop	_	_
29	MEK-dependent	mek-dependent	JJ	JJ	_	25	acl:relcl	_	_
30	.	.	.	.	_	5	punct	_	_

1	Experiments	experiment	NNS	NNS	_	7	nsubj	_	_
2	in	in	IN	IN	_	6	case	_	_
3	COS-1	cos-1	NN	NN	_	6	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	EL-4	el-4	NN	NN	_	3	conj	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	confirmed	confirm	VBD	VBD	_	0	root	_	_
8	both	both	DT	DT	_	9	det	_	_
9	hypotheses	hypothesis	NNS	NNS	_	7	dobj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	revealed	reveal	VBD	VBD	_	7	conj	_	_
12	that	that	IN	IN	_	20	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	second	second	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	20	nsubj	_	_
16	activated	activate	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	Tpl-2	tpl-2	NN	NN	_	16	nmod	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	11	ccomp	_	_
21	.	.	.	.	_	7	punct	_	_

1	While	while	IN	IN	_	17	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	activation	activation	NN	NN	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	an	a	DT	DT	_	12	det	_	_
10	NFAT-driven	nfat-driven	JJ	JJ	_	12	amod	_	_
11	minimal	minimal	JJ	JJ	_	12	amod	_	_
12	promoter	promoter	NN	NN	_	7	conj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	Tpl-2	tpl-2	NN	NN	_	3	nmod	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	fully	fully	RB	RB	_	17	advmod	_	_
17	blocked	block	VBN	VBN	_	30	advcl	_	_
18	by	by	IN	IN	_	24	case	_	_
19	the	the	DT	DT	_	24	det	_	_
20	dominant	dominant	JJ	JJ	_	24	amod	_	_
21	negative	negative	JJ	JJ	_	24	amod	_	_
22	mutant	mutant	JJ	JJ	_	24	amod	_	_
23	NFAT	nfat	NN	NN	_	24	compound	_	_
24	delta418	delta418	NN	NN	_	17	nmod	_	_
25	,	,	,	,	_	30	punct	_	_
26	it	it	PRP	PRP	_	30	nsubjpass	_	_
27	was	be	VBD	VBD	_	30	auxpass	_	_
28	only	only	RB	RB	_	29	advmod	_	_
29	partially	partially	RB	RB	_	30	advmod	_	_
30	blocked	block	VBN	VBN	_	0	root	_	_
31	by	by	IN	IN	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	calcineurin	calcineurin	NN	NN	_	36	compound	_	_
34	inhibitor	inhibitor	NN	NN	_	36	compound	_	_
35	cyclosporin	cyclosporin	NN	NN	_	36	compound	_	_
36	A	a	NN	NN	_	30	nmod	_	_
37	suggesting	suggest	VBG	VBG	_	30	xcomp	_	_
38	that	that	IN	IN	_	46	mark	_	_
39	the	the	DT	DT	_	42	det	_	_
40	Tpl-2-mediated	tpl-2-mediated	JJ	JJ	_	42	amod	_	_
41	NFAT	nfat	NN	NN	_	42	compound	_	_
42	activation	activation	NN	NN	_	46	nsubj	_	_
43	is	be	VBZ	VBZ	_	46	cop	_	_
44	under	under	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	control	control	NN	NN	_	37	ccomp	_	_
47	of	of	IN	IN	_	49	case	_	_
48	a	a	DT	DT	_	49	det	_	_
49	combination	combination	NN	NN	_	46	nmod	_	_
50	of	of	IN	IN	_	54	case	_	_
51	calcineurin-dependent	calcineurin-dependent	JJ	JJ	_	54	amod	_	_
52	and	and	CC	CC	_	51	cc	_	_
53	independent	independent	JJ	JJ	_	51	conj	_	_
54	pathways	pathway	NNS	NNS	_	49	nmod	_	_
55	.	.	.	.	_	30	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	pathways	pathway	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	fully	fully	RB	RB	_	5	advmod	_	_
5	blocked	block	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	Bcl-2	bcl-2	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	Bcl-X(L)	bcl-x(l)	NN	NN	_	7	conj	_	_
10	.	.	.	.	_	5	punct	_	_

1	Heterogeneous	heterogeneous	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	lipocalin	lipocalin	NN	NN	_	6	compound	_	_
6	NGAL	ngal	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	primary	primary	JJ	JJ	_	10	amod	_	_
9	breast	breast	NN	NN	_	10	compound	_	_
10	cancers	cancer	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	neu	neu	NN	NN	_	7	nmod:npmod	_	_
7	oncogene-initiated	oncogene-initiated	JJ	JJ	_	10	amod	_	_
8	rat	rat	NN	NN	_	10	compound	_	_
9	mammary	mammary	JJ	JJ	_	10	amod	_	_
10	carcinomas	carcinoma	NNS	NNS	_	12	nsubj	_	_
11	uniquely	uniquely	RB	RB	_	12	advmod	_	_
12	over-express	over-express	VBP	VBP	_	4	ccomp	_	_
13	neu-related	neu-related	JJ	JJ	_	14	amod	_	_
14	lipocalin	lipocalin	NN	NN	_	12	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NRL	nrl	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	a	a	DT	DT	_	20	det	_	_
20	member	member	NN	NN	_	14	appos	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	calycin	calycin	NN	NN	_	25	compound	_	_
24	protein	protein	NN	NN	_	25	compound	_	_
25	superfamily	superfamily	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	characterize	characterize	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	8	det	_	_
6	putative	putative	JJ	JJ	_	8	amod	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	homolog	homolog	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NRL	nrl	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	neutrophil	neutrophil	NN	NN	_	14	compound	_	_
13	gelatinase-associated	gelatinase-associated	JJ	JJ	_	14	amod	_	_
14	lipocalin	lipocalin	NN	NN	_	8	appos	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NGAL	ngal	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	4	punct	_	_

1	ngal	ngal	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	8	case	_	_
7	moderate	moderate	JJ	JJ	_	8	amod	_	_
8	levels	level	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	15	case	_	_
10	only	only	RB	RB	_	13	advmod	_	_
11	2	2	CD	CD	_	13	compound	_	_
12	of	of	IN	IN	_	13	advmod	_	_
13	17	17	CD	CD	_	15	nummod	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	tissues	tissue	NNS	NNS	_	5	nmod	_	_
16	examined	examine	VBN	VBN	_	15	acl	_	_
17	,	,	,	,	_	15	punct	_	_
18	breast	breast	NN	NN	_	15	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	lung	lung	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	5	advmod	_	_
2	breast	breast	NN	NN	_	3	compound	_	_
3	cancers	cancer	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	15	advcl	_	_
6	for	for	IN	IN	_	8	case	_	_
7	NGAL	ngal	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	15	punct	_	_
13	they	they	PRP	PRP	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	exhibit	exhibit	VB	VB	_	15	xcomp	_	_
18	heterogeneous	heterogeneous	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	15	punct	_	_

1	NGAL	ngal	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	3	nsubj	_	_
3	varied	vary	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	these	these	DT	DT	_	6	det	_	_
6	tumors	tumor	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	8	case	_	_
8	undetectable	undetectable	JJ	JJ	_	3	dep	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	exceeding	exceed	VBG	VBG	_	8	nmod	_	_
11	those	those	DT	DT	_	10	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	normal	normal	JJ	JJ	_	15	amod	_	_
14	breast	breast	NN	NN	_	15	compound	_	_
15	parenchyma	parenchyma	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Immuno-histochemical	immuno-histochemical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	confirmed	confirm	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NGAL	ngal	NN	NN	_	5	nmod	_	_
8	within	within	IN	IN	_	11	case	_	_
9	breast	breast	NN	NN	_	11	compound	_	_
10	carcinoma	carcinoma	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	but	but	CC	CC	_	3	cc	_	_
13	detected	detect	VBD	VBD	_	3	conj	_	_
14	only	only	RB	RB	_	16	advmod	_	_
15	low	low	JJ	JJ	_	16	amod	_	_
16	levels	level	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	protein	protein	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	normal	normal	JJ	JJ	_	23	amod	_	_
22	ductal	ductal	JJ	JJ	_	23	amod	_	_
23	epithelium	epithelium	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	large	large	JJ	JJ	_	5	amod	_	_
5	amounts	amount	NNS	NNS	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	aux	_	_
10	localized	localized	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	lumen	lumen	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	breast	breast	NN	NN	_	17	compound	_	_
17	ducts	duct	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	vicinity	vicinity	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	NGAL-expressing	ngal-expressing	JJ	JJ	_	23	amod	_	_
23	tumors	tumor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Interestingly	interestingly	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	unlike	unlike	IN	IN	_	4	case	_	_
4	NRL	nrl	NN	NN	_	20	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	rat	rat	NN	NN	_	8	compound	_	_
7	mammary	mammary	JJ	JJ	_	8	amod	_	_
8	carcinomas	carcinoma	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	20	punct	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	association	association	NN	NN	_	20	nsubjpass	_	_
13	between	between	IN	IN	_	15	case	_	_
14	NGAL	ngal	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	HER-2/neu	her-2/neu	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	conj	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	found	find	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	breast	breast	NN	NN	_	24	compound	_	_
24	tumors	tumor	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	14	nsubjpass	_	_
7	between	between	IN	IN	_	9	case	_	_
8	NGAL	ngal	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	breast	breast	NN	NN	_	12	compound	_	_
12	cancer	cancer	NN	NN	_	9	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	18	case	_	_
16	several	several	JJ	JJ	_	18	amod	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	markers	marker	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	poor	poor	JJ	JJ	_	21	amod	_	_
21	prognosis	prognosis	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	including	include	VBG	VBG	_	28	case	_	_
24	estrogen	estrogen	NN	NN	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	progesterone	progesterone	NN	NN	_	27	nmod:npmod	_	_
27	receptor-negative	receptor-negative	JJ	JJ	_	24	conj	_	_
28	status	status	NN	NN	_	18	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	high	high	JJ	JJ	_	31	amod	_	_
31	proliferation	proliferation	NN	NN	_	28	conj	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	S-phase	s-phase	NN	NN	_	34	compound	_	_
34	fraction	fraction	NN	NN	_	31	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	14	punct	_	_

1	NGAL	ngal	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	stratified	stratify	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	6	case	_	_
6	high	high	JJ	JJ	_	4	advcl	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	low	low	JJ	JJ	_	6	conj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	breast	breast	NN	NN	_	11	compound	_	_
11	cancers	cancer	NNS	NNS	_	4	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	cohort	cohort	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	node-positive	node-positive	JJ	JJ	_	17	amod	_	_
17	patients	patient	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	known	known	JJ	JJ	_	20	amod	_	_
20	outcome	outcome	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	association	association	NN	NN	_	13	nsubjpass	_	_
4	between	between	IN	IN	_	6	case	_	_
5	NGAL	ngal	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	disease-free	disease-free	JJ	JJ	_	11	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	overall	overall	JJ	JJ	_	8	conj	_	_
11	survival	survival	NN	NN	_	6	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	macrophages	macrophage	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	mechanical	mechanical	JJ	JJ	_	7	amod	_	_
7	ventilation	ventilation	NN	NN	_	1	nmod	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	7	advmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Positive-pressure	positive-pressure	JJ	JJ	_	3	amod	_	_
2	mechanical	mechanical	JJ	JJ	_	3	amod	_	_
3	ventilation	ventilation	NN	NN	_	4	nsubj	_	_
4	supports	support	VBZ	VBZ	_	0	root	_	_
5	gas	gas	NN	NN	_	6	compound	_	_
6	exchange	exchange	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	patients	patient	NNS	NNS	_	6	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	respiratory	respiratory	JJ	JJ	_	11	amod	_	_
11	failure	failure	NN	NN	_	8	nmod	_	_
12	but	but	CC	CC	_	4	cc	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	responsible	responsible	JJ	JJ	_	4	conj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	significant	significant	JJ	JJ	_	19	amod	_	_
18	lung	lung	NN	NN	_	19	compound	_	_
19	injury	injury	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	developed	develop	VBN	VBN	_	0	root	_	_
8	an	a	DT	DT	_	11	det	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	model	model	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	which	which	WDT	WDT	_	19	nmod	_	_
14	isolated	isolate	VBN	VBN	_	16	amod	_	_
15	lung	lung	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	19	nsubjpass	_	_
17	can	can	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	submitted	submit	VBN	VBN	_	11	acl:relcl	_	_
20	to	to	TO	TO	_	25	case	_	_
21	a	a	DT	DT	_	25	det	_	_
22	prolonged	prolonged	JJ	JJ	_	25	amod	_	_
23	cyclic	cyclic	JJ	JJ	_	25	amod	_	_
24	pressure-stretching	pressure-stretching	JJ	JJ	_	25	amod	_	_
25	strain	strain	NN	NN	_	19	nmod	_	_
26	resembling	resemble	VBG	VBG	_	11	acl	_	_
27	that	that	DT	DT	_	26	xcomp	_	_
28	of	of	IN	IN	_	31	case	_	_
29	conventional	conventional	JJ	JJ	_	31	amod	_	_
30	mechanical	mechanical	JJ	JJ	_	31	amod	_	_
31	ventilation	ventilation	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	model	model	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	cells	cell	NNS	NNS	_	12	nsubjpass	_	_
6	cultured	culture	VBN	VBN	_	5	acl	_	_
7	on	on	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	Silastic	silastic	JJ	JJ	_	10	amod	_	_
10	membrane	membrane	NN	NN	_	6	nmod	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	elongated	elongate	VBN	VBN	_	0	root	_	_
13	up	up	RB	RB	_	16	advmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	7	7	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
19	initial	initial	JJ	JJ	_	20	amod	_	_
20	diameter	diameter	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	corresponding	correspond	VBG	VBG	_	12	xcomp	_	_
23	to	to	TO	TO	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	12	12	CD	CD	_	26	compound	_	_
26	%	%	NN	NN	_	27	amod	_	_
27	increase	increase	NN	NN	_	22	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	surface	surface	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	lung	lung	NN	NN	_	3	compound	_	_
3	macrophage	macrophage	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	as	as	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	main	main	JJ	JJ	_	10	amod	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	source	source	NN	NN	_	5	nmod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	critical	critical	JJ	JJ	_	14	amod	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	mediators	mediator	NNS	NNS	_	10	nmod	_	_
15	such	such	JJ	JJ	_	19	case	_	_
16	as	as	IN	IN	_	15	mwe	_	_
17	tumor	tumor	NN	NN	_	19	compound	_	_
18	necrosis	necrosis	NN	NN	_	19	compound	_	_
19	factor-alpha	factor-alpha	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	chemokines	chemokine	NNS	NNS	_	10	conj	_	_
23	interleukin	interleukin	NN	NN	_	22	dep	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	IL	il	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	-8	-8	CD	CD	_	23	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	-6	-6	CD	CD	_	27	conj	_	_
30	,	,	,	,	_	10	punct	_	_
31	and	and	CC	CC	_	10	cc	_	_
32	matrix	matrix	NN	NN	_	33	compound	_	_
33	metalloproteinase-9	metalloproteinase-9	NN	NN	_	10	conj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	this	this	DT	DT	_	37	det	_	_
36	model	model	JJ	JJ	_	37	amod	_	_
37	system	system	NN	NN	_	5	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	mechanical	mechanical	JJ	JJ	_	40	amod	_	_
40	ventilation	ventilation	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	mediators	mediator	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	measured	measure	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	supernatants	supernatant	NNS	NNS	_	4	nmod	_	_
7	from	from	IN	IN	_	10	case	_	_
8	ventilated	ventilate	VBN	VBN	_	10	amod	_	_
9	alveolar	alveolar	JJ	JJ	_	10	amod	_	_
10	macrophages	macrophage	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	monocyte-derived	monocyte-derived	JJ	JJ	_	13	amod	_	_
13	macrophages	macrophage	NNS	NNS	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	promonocytic	promonocytic	JJ	JJ	_	18	amod	_	_
17	THP-1	thp-1	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor-kappaB	factor-kappab	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	activated	activate	VBN	VBN	_	4	xcomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	ventilated	ventilate	VBN	VBN	_	10	amod	_	_
10	macrophages	macrophage	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Synergistic	synergistic	JJ	JJ	_	3	amod	_	_
2	proinflammatory	proinflammatory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	mechanical	mechanical	JJ	JJ	_	6	amod	_	_
6	stress	stress	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	molecules	molecule	NNS	NNS	_	6	conj	_	_
9	such	such	JJ	JJ	_	12	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	bacterial	bacterial	JJ	JJ	_	12	amod	_	_
12	endotoxin	endotoxin	NN	NN	_	8	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	observed	observe	VBN	VBN	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	mechanical	mechanical	JJ	JJ	_	19	amod	_	_
19	ventilation	ventilation	NN	NN	_	23	nsubj	_	_
20	might	might	MD	MD	_	23	aux	_	_
21	be	be	VB	VB	_	23	cop	_	_
22	particularly	particularly	RB	RB	_	23	advmod	_	_
23	deleterious	deleterious	JJ	JJ	_	16	ccomp	_	_
24	in	in	IN	IN	_	28	case	_	_
25	preinjured	preinjured	JJ	JJ	_	28	amod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	infected	infected	JJ	JJ	_	25	conj	_	_
28	lungs	lung	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	14	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	prevented	prevent	VBD	VBD	_	0	root	_	_
3	IL-8	il-8	NN	NN	_	8	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tumor	tumor	NN	NN	_	3	conj	_	_
6	necrosis	necrosis	NN	NN	_	8	compound	_	_
7	factor-alpha	factor-alpha	NN	NN	_	8	compound	_	_
8	secretion	secretion	NN	NN	_	2	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	ventilated	ventilate	VBN	VBN	_	11	amod	_	_
11	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Mechanical	mechanical	JJ	JJ	_	2	amod	_	_
2	ventilation	ventilation	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	low	low	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	IL-8	il-8	NN	NN	_	8	compound	_	_
8	secretion	secretion	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	13	case	_	_
10	alveolar	alveolar	JJ	JJ	_	13	amod	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	II-like	ii-like	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Other	other	JJ	JJ	_	4	amod	_	_
2	lung	lung	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	types	type	NNS	NNS	_	15	nsubj	_	_
5	such	such	JJ	JJ	_	8	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	bronchial	bronchial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	8	conj	_	_
15	failed	fail	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	produce	produce	VB	VB	_	15	xcomp	_	_
18	IL-8	il-8	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	26	case	_	_
20	response	response	NN	NN	_	26	dep	_	_
21	to	to	TO	TO	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	prolonged	prolonged	JJ	JJ	_	25	amod	_	_
24	cyclic	cyclic	JJ	JJ	_	25	amod	_	_
25	pressure-stretching	pressure-stretching	JJ	JJ	_	26	amod	_	_
26	load	load	NN	NN	_	17	nmod	_	_
27	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	model	model	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	of	of	IN	IN	_	6	case	_	_
5	particular	particular	JJ	JJ	_	6	amod	_	_
6	value	value	NN	NN	_	0	root	_	_
7	for	for	IN	IN	_	8	mark	_	_
8	exploring	explore	VBG	VBG	_	6	dep	_	_
9	physical	physical	JJ	JJ	_	10	amod	_	_
10	stress-induced	stress-induced	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	8	dobj	_	_
13	,	,	,	,	_	8	punct	_	_
14	as	as	RB	RB	_	8	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	for	for	IN	IN	_	18	mark	_	_
18	testing	test	VBG	VBG	_	8	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effects	effect	NNS	NNS	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	novel	novel	JJ	JJ	_	24	amod	_	_
23	ventilatory	ventilatory	JJ	JJ	_	24	amod	_	_
24	strategies	strategy	NNS	NNS	_	20	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	adjunctive	adjunctive	JJ	JJ	_	27	amod	_	_
27	substances	substance	NNS	NNS	_	24	conj	_	_
28	aimed	aim	VBN	VBN	_	27	acl	_	_
29	at	at	IN	IN	_	30	mark	_	_
30	modulating	modulate	VBG	VBG	_	28	advcl	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	33	nsubj	_	_
33	induced	induce	VBN	VBN	_	30	dep	_	_
34	by	by	IN	IN	_	36	case	_	_
35	mechanical	mechanical	JJ	JJ	_	36	amod	_	_
36	ventilation	ventilation	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	6	punct	_	_

1	Host	host	NN	NN	_	2	compound	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
5	parasitism	parasitism	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
12	factor	factor	NN	NN	_	16	compound	_	_
13	of	of	IN	IN	_	16	amod	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	2	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Post	post	IN	IN	_	3	amod	_	_
2	HIV-1	hiv-1	NN	NN	_	3	compound	_	_
3	entry	entry	NN	NN	_	12	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	productive	productive	JJ	JJ	_	7	amod	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	3	appos	_	_
8	of	of	IN	IN	_	11	case	_	_
9	primary	primary	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	requires	require	VBZ	VBZ	_	0	root	_	_
13	overcoming	overcome	VBG	VBG	_	12	xcomp	_	_
14	several	several	JJ	JJ	_	16	amod	_	_
15	cellular	cellular	JJ	JJ	_	16	amod	_	_
16	blocks	block	NNS	NNS	_	13	dobj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	provirus	provirus	NN	NN	_	16	nmod	_	_
19	establishment	establishment	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	replication	replication	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	unknown	unknown	JJ	JJ	_	6	amod	_	_
4	host	host	NN	NN	_	6	compound	_	_
5	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
6	events	event	NNS	NNS	_	1	nmod	_	_
7	overcomes	overcome	VBZ	VBZ	_	0	root	_	_
8	such	such	JJ	JJ	_	10	amod	_	_
9	inhibitory	inhibitory	JJ	JJ	_	10	amod	_	_
10	steps	step	NNS	NNS	_	7	dobj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	concomitant	concomitant	JJ	JJ	_	7	conj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	the	the	DT	DT	_	7	det	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	NFATc	nfatc	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	sufficient	sufficient	JJ	JJ	_	2	ccomp	_	_
10	as	as	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	cellular	cellular	JJ	JJ	_	13	amod	_	_
13	factor	factor	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	induce	induce	VB	VB	_	13	acl	_	_
16	a	a	DT	DT	_	19	det	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	permissive	permissive	JJ	JJ	_	19	amod	_	_
19	state	state	NN	NN	_	15	dobj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	HIV-1	hiv-1	NN	NN	_	22	compound	_	_
22	replication	replication	NN	NN	_	19	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	primary	primary	JJ	JJ	_	27	amod	_	_
25	CD4+	cd4+	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	NFATc	nfatc	NN	NN	_	2	nsubj	_	_
2	overcame	overcome	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	blockade	blockade	NN	NN	_	2	dobj	_	_
5	at	at	IN	IN	_	7	case	_	_
6	reverse	reverse	JJ	JJ	_	7	amod	_	_
7	transcription	transcription	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	permitted	permit	VBD	VBD	_	2	conj	_	_
10	active	active	JJ	JJ	_	12	amod	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	replication	replication	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	2	punct	_	_

1	Pharmacologic	pharmacologic	JJ	JJ	_	2	amod	_	_
2	blockade	blockade	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	endogenous	endogenous	JJ	JJ	_	6	amod	_	_
5	NFAT	nfat	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	FK506	fk506	NN	NN	_	6	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	CsA	csa	NN	NN	_	8	conj	_	_
11	inhibited	inhibit	VBD	VBD	_	0	root	_	_
12	synthesis	synthesis	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	reverse	reverse	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	also	also	RB	RB	_	11	advmod	_	_
18	potently	potently	RB	RB	_	19	advmod	_	_
19	blocked	block	VBD	VBD	_	11	dep	_	_
20	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
21	replication	replication	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	11	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	5	nsubj	_	_
3	therefore	therefore	RB	RB	_	5	advmod	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	become	become	VB	VB	_	0	root	_	_
6	competent	competent	JJ	JJ	_	5	xcomp	_	_
7	for	for	IN	IN	_	9	case	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	replication	replication	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	control	control	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	regulated	regulate	VBN	VBN	_	15	amod	_	_
14	host	host	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	such	such	JJ	JJ	_	21	case	_	_
17	as	as	IN	IN	_	16	mwe	_	_
18	the	the	DT	DT	_	21	det	_	_
19	NFATc	nfatc	NN	NN	_	21	compound	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	host	host	NN	NN	_	3	compound	_	_
3	mechanisms	mechanism	NNS	NNS	_	11	nsubj	_	_
4	regulated	regulate	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	such	such	JJ	JJ	_	8	amod	_	_
7	permissivity	permissivity	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	4	nmod	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	potential	potential	JJ	JJ	_	11	amod	_	_
11	targets	target	NNS	NNS	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	anti-HIV-1	anti-hiv-1	JJ	JJ	_	14	amod	_	_
14	therapy	therapy	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Stat6	stat6	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	interleukin-4	interleukin-4	NN	NN	_	6	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	differentiation	differentiation	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	naive	naive	JJ	JJ	_	9	amod	_	_
5	T-helper	t-helper	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	Th	th	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	into	into	IN	IN	_	14	case	_	_
11	cytokine-secreting	cytokine-secreting	JJ	JJ	_	14	amod	_	_
12	effector	effector	NN	NN	_	14	compound	_	_
13	Th	th	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	2	nmod	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	exposure	exposure	NN	NN	_	15	dobj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	multiple	multiple	JJ	JJ	_	19	amod	_	_
19	signals	signal	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	exogenous	exogenous	JJ	JJ	_	23	amod	_	_
23	cytokines	cytokine	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Interleukin-4	interleukin-4	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-4	il-4	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	plays	play	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	major	major	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	process	process	NN	NN	_	5	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	promoting	promote	VBG	VBG	_	5	advcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	differentiation	differentiation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	IL-4-secreting	il-4-secreting	JJ	JJ	_	19	amod	_	_
18	Th2	th2	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Th2	th2	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	IL-4	il-4	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	tightly	tightly	RB	RB	_	10	advmod	_	_
10	controlled	control	VBN	VBN	_	0	root	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	transcription	transcription	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	coordinated	coordinate	VBN	VBN	_	19	amod	_	_
19	binding	binding	NN	NN	_	10	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	multiple	multiple	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	regulatory	regulatory	JJ	JJ	_	26	amod	_	_
26	elements	element	NNS	NNS	_	19	nmod	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	proximal	proximal	JJ	JJ	_	31	amod	_	_
30	promoter	promoter	NN	NN	_	31	compound	_	_
31	region	region	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	11	amod	_	_
2	factor	factor	NN	NN	_	11	compound	_	_
3	of	of	IN	IN	_	11	amod	_	_
4	activated	activate	VBN	VBN	_	11	amod	_	_
5	T	t	NN	NN	_	11	compound	_	_
6	cell	cell	NN	NN	_	11	compound	_	_
7	(	(	-LRB-	-LRB-	_	11	punct	_	_
8	NFAT	nfat	NN	NN	_	11	compound	_	_
9	)	)	-RRB-	-RRB-	_	11	punct	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	12	nsubj	_	_
12	play	play	VBP	VBP	_	0	root	_	_
13	a	a	DT	DT	_	15	det	_	_
14	critical	critical	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	17	mark	_	_
17	regulating	regulate	VBG	VBG	_	12	advcl	_	_
18	IL-4	il-4	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	17	dobj	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	interact	interact	VBP	VBP	_	12	conj	_	_
22	with	with	IN	IN	_	26	case	_	_
23	up	up	RB	RB	_	25	advmod	_	_
24	to	to	TO	TO	_	25	dep	_	_
25	five	five	CD	CD	_	26	nummod	_	_
26	sequences	sequence	NNS	NNS	_	21	nmod	_	_
27	(	(	-LRB-	-LRB-	_	26	punct	_	_
28	termed	term	VBN	VBN	_	26	acl	_	_
29	P0	p0	NN	NN	_	28	xcomp	_	_
30	through	through	IN	IN	_	29	amod	_	_
31	P4	p4	NN	NN	_	29	dep	_	_
32	)	)	-RRB-	-RRB-	_	26	punct	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	IL-4	il-4	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	26	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	15	nsubjpass	_	_
4	by	by	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	7	nmod	_	_
6	IL-4	il-4	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	3	acl:relcl	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-4	il-4	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	known	know	VBN	VBN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	although	although	IN	IN	_	33	mark	_	_
18	the	the	DT	DT	_	21	det	_	_
19	IL-4-activated	il-4-activated	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	33	nsubjpass	_	_
22	signal	signal	NN	NN	_	23	compound	_	_
23	transducer	transducer	NN	NN	_	21	dep	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	activator	activator	NN	NN	_	23	conj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	transcription	transcription	NN	NN	_	25	nmod	_	_
28	6	6	CD	CD	_	27	nummod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	Stat6	stat6	NN	NN	_	21	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	is	be	VBZ	VBZ	_	33	auxpass	_	_
33	required	require	VBN	VBN	_	15	advcl	_	_
34	for	for	IN	IN	_	36	case	_	_
35	this	this	DT	DT	_	36	det	_	_
36	effect	effect	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Stat6	stat6	NN	NN	_	6	nsubj	_	_
6	interacts	interact	VBZ	VBZ	_	2	ccomp	_	_
7	with	with	IN	IN	_	10	case	_	_
8	three	three	CD	CD	_	10	nummod	_	_
9	binding	bind	VBG	VBG	_	10	amod	_	_
10	sites	site	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	IL-4	il-4	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	10	nmod	_	_
16	by	by	IN	IN	_	20	case	_	_
17	electrophoretic	electrophoretic	JJ	JJ	_	20	amod	_	_
18	mobility	mobility	NN	NN	_	20	compound	_	_
19	shift	shift	NN	NN	_	20	compound	_	_
20	assays	assay	NNS	NNS	_	6	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	sites	site	NNS	NNS	_	3	nsubj	_	_
3	overlap	overlap	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	P1	p1	NN	NN	_	7	compound	_	_
6	,	,	,	,	_	7	punct	_	_
7	P2	p2	NN	NN	_	3	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	P4	p4	NN	NN	_	12	compound	_	_
11	NFAT	nfat	NN	NN	_	12	compound	_	_
12	elements	element	NNS	NNS	_	7	conj	_	_
13	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Stat6	stat6	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	regulating	regulate	VBG	VBG	_	4	acl	_	_
9	IL-4	il-4	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	used	use	VBD	VBD	_	0	root	_	_
14	Stat6-deficient	stat6-deficient	JJ	JJ	_	17	amod	_	_
15	Jurkat	jurkat	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	dobj	_	_
18	with	with	IN	IN	_	23	case	_	_
19	different	different	JJ	JJ	_	23	amod	_	_
20	intact	intact	JJ	JJ	_	23	amod	_	_
21	IL-4	il-4	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	constructs	construct	NNS	NNS	_	17	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	cotransfection	cotransfection	NN	NN	_	26	compound	_	_
26	assays	assay	NNS	NNS	_	13	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	31	mark	_	_
4	,	,	,	,	_	31	punct	_	_
5	whereas	whereas	IN	IN	_	17	mark	_	_
6	a	a	DT	DT	_	9	det	_	_
7	multimerized	multimerized	JJ	JJ	_	9	amod	_	_
8	response	response	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	17	nsubjpass	_	_
10	from	from	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	germline	germline	NN	NN	_	14	compound	_	_
13	IgE	ige	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	9	nmod	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	highly	highly	RB	RB	_	17	advmod	_	_
17	induced	induce	VBN	VBN	_	31	advcl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	IL-4	il-4	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	Stat6-expressing	stat6-expressing	JJ	JJ	_	23	amod	_	_
22	Jurkat	jurkat	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	31	punct	_	_
25	the	the	DT	DT	_	29	det	_	_
26	intact	intact	JJ	JJ	_	29	amod	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	IL-4	il-4	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	31	nsubjpass	_	_
30	was	be	VBD	VBD	_	31	auxpass	_	_
31	repressed	repress	VBN	VBN	_	2	ccomp	_	_
32	under	under	IN	IN	_	34	case	_	_
33	similar	similar	JJ	JJ	_	34	amod	_	_
34	conditions	condition	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	function	function	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Stat6	stat6	NN	NN	_	5	nmod	_	_
8	is	be	VBZ	VBZ	_	10	cop	_	_
9	highly	highly	RB	RB	_	10	advmod	_	_
10	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
11	on	on	IN	IN	_	13	case	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	context	context	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	factor	factor	NN	NN	_	18	nsubj	_	_
18	promotes	promote	VBZ	VBZ	_	10	conj	_	_
19	IL-4	il-4	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	dobj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	an	a	DT	DT	_	25	det	_	_
24	indirect	indirect	JJ	JJ	_	25	amod	_	_
25	manner	manner	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Adaptor	adaptor	NN	NN	_	2	compound	_	_
2	function	function	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	Syk	syk	NN	NN	_	8	compound	_	_
6	kinases-interacting	kinases-interacting	JJ	JJ	_	8	amod	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	3BP2	3bp2	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	IL-2	il-2	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	2	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Syk-family	syk-family	JJ	JJ	_	3	amod	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	kinases	kinase	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	lymphocyte	lymphocyte	NN	NN	_	5	nmod	_	_
8	development	development	NN	NN	_	7	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	activation	activation	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	16	advcl	_	_
2	a	a	DT	DT	_	5	det	_	_
3	yeast	yeast	NN	NN	_	5	compound	_	_
4	two-hybrid	two-hybrid	JJ	JJ	_	5	amod	_	_
5	screen	screen	NN	NN	_	1	dobj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	identify	identify	VB	VB	_	1	advcl	_	_
8	Syk	syk	NN	NN	_	10	compound	_	_
9	kinases-interacting	kinases-interacting	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	dobj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	SKIPs	skip	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	isolated	isolate	VBD	VBD	_	0	root	_	_
17	3BP2	3bp2	NN	NN	_	16	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	an	a	DT	DT	_	22	det	_	_
20	Abl	abl	NN	NN	_	22	compound	_	_
21	SH3-interacting	sh3-interacting	JJ	JJ	_	22	amod	_	_
22	protein	protein	NN	NN	_	17	appos	_	_
23	of	of	IN	IN	_	25	case	_	_
24	unknown	unknown	JJ	JJ	_	25	amod	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	3BP2	3bp2	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	selectively	selectively	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	hematopoietic/lymphoid	hematopoietic/lymphoid	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	bound	bind	VBD	VBD	_	4	conj	_	_
10	via	via	IN	IN	_	16	case	_	_
11	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
12	SH2	sh2	NN	NN	_	16	compound	_	_
13	domain	domain	NN	NN	_	16	compound	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	Syk-family	syk-family	JJ	JJ	_	16	amod	_	_
16	kinases	kinase	NNS	NNS	_	9	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	mammalian	mammalian	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	including	include	VBG	VBG	_	26	case	_	_
22	in	in	IN	IN	_	26	case	_	_
23	antigen	antigen	NN	NN	_	26	compound	_	_
24	receptor-stimulated	receptor-stimulated	JJ	JJ	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	addition	addition	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	Zap-70	zap-70	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	3BP2	3bp2	NN	NN	_	9	compound	_	_
8	SH2	sh2	NN	NN	_	9	compound	_	_
9	domain	domain	NN	NN	_	10	nsubj	_	_
10	associated	associate	VBD	VBD	_	0	root	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	10	advmod	_	_
13	with	with	IN	IN	_	14	case	_	_
14	LAT	lat	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	Grb2	grb2	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	PLCgamma1	plcgamma1	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	Cbl	cbl	NN	NN	_	14	conj	_	_
22	from	from	IN	IN	_	26	case	_	_
23	activated	activate	VBN	VBN	_	26	amod	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lysates	lysate	NNS	NNS	_	14	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	3BP2	3bp2	NN	NN	_	3	compound	_	_
3	overexpression	overexpression	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	NFAT	nfat	NN	NN	_	10	conj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	AP-1	ap-1	NN	NN	_	16	compound	_	_
16	elements	element	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	dependent	dependent	JJ	JJ	_	0	root	_	_
5	on	on	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	SH2	sh2	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	pleckstrin-homology	pleckstrin-homology	JJ	JJ	_	7	conj	_	_
10	domains	domain	NNS	NNS	_	4	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	3BP2	3bp2	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	required	require	VBD	VBD	_	4	conj	_	_
16	functional	functional	JJ	JJ	_	18	amod	_	_
17	Syk	syk	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	15	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	Ras	ras	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	18	punct	_	_
22	and	and	CC	CC	_	18	cc	_	_
23	calcineurin	calcineurin	NN	NN	_	18	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	3BP2	3bp2	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	an	a	DT	DT	_	7	det	_	_
6	important	important	JJ	JJ	_	7	amod	_	_
7	adaptor	adaptor	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	couple	couple	VB	VB	_	7	acl:relcl	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	Zap-70/Syk	zap-70/syk	NN	NN	_	10	dobj	_	_
13	to	to	TO	TO	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	LAT-containing	lat-containing	JJ	JJ	_	17	amod	_	_
16	signaling	signal	VBG	VBG	_	17	amod	_	_
17	complex	complex	NN	NN	_	10	nmod	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	TCR-mediated	tcr-mediated	JJ	JJ	_	22	amod	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	PAK	pak	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	the	the	DT	DT	_	9	det	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	cytoskeleton	cytoskeleton	NN	NN	_	1	conj	_	_
10	by	by	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	linker	linker	NN	NN	_	14	compound	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	SLP-76	slp-76	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	linker	linker	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	nmod	_	_
6	enables	enable	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	18	det	_	_
8	T	t	NN	NN	_	18	compound	_	_
9	cell	cell	NN	NN	_	18	compound	_	_
10	antigen	antigen	NN	NN	_	18	compound	_	_
11	receptor	receptor	NN	NN	_	18	compound	_	_
12	(	(	-LRB-	-LRB-	_	18	punct	_	_
13	TCR	tcr	NN	NN	_	18	compound	_	_
14	)	)	-RRB-	-RRB-	_	18	punct	_	_
15	-associated	-associated	JJ	JJ	_	18	amod	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	6	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	phosphorylate	phosphorylate	VB	VB	_	6	xcomp	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	regulate	regulate	VB	VB	_	20	conj	_	_
23	effector	effector	NN	NN	_	24	compound	_	_
24	molecules	molecule	NNS	NNS	_	20	dobj	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	generate	generate	VBP	VBP	_	24	acl:relcl	_	_
27	second	second	JJ	JJ	_	28	amod	_	_
28	messengers	messenger	NNS	NNS	_	26	dobj	_	_
29	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	SLP-76	slp-76	NN	NN	_	8	compound	_	_
7	linker	linker	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	9	nsubj	_	_
9	interacts	interact	VBZ	VBZ	_	2	ccomp	_	_
10	with	with	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	nck	nck	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	an	a	DT	DT	_	16	det	_	_
15	adaptor	adaptor	NN	NN	_	16	compound	_	_
16	protein	protein	NN	NN	_	12	appos	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	Vav	vav	NN	NN	_	12	conj	_	_
20	,	,	,	,	_	19	punct	_	_
21	a	a	DT	DT	_	25	det	_	_
22	guanine	guanine	JJ	JJ	_	25	amod	_	_
23	nucleotide	nucleotide	NN	NN	_	25	compound	_	_
24	exchange	exchange	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	19	appos	_	_
26	for	for	IN	IN	_	28	case	_	_
27	Rho-family	rho-family	JJ	JJ	_	28	amod	_	_
28	GTPases	gtpase	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	assembly	assembly	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	tri-molecular	tri-molecular	JJ	JJ	_	6	amod	_	_
6	complex	complex	NN	NN	_	2	nmod	_	_
7	permits	permit	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	Rho-family	rho-family	JJ	JJ	_	11	amod	_	_
11	GTPases	gtpase	NNS	NNS	_	7	dobj	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	regulate	regulate	VB	VB	_	7	xcomp	_	_
14	target	target	NN	NN	_	15	compound	_	_
15	effectors	effector	NNS	NNS	_	13	dobj	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	interact	interact	VBP	VBP	_	15	acl:relcl	_	_
18	through	through	IN	IN	_	19	case	_	_
19	nck	nck	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	turn	turn	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	assembly	assembly	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	complex	complex	NN	NN	_	4	nmod	_	_
8	mediates	mediate	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	enzymatic	enzymatic	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	p21-activated	p21-activated	JJ	JJ	_	16	amod	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	kinase	kinase	NN	NN	_	11	nmod	_	_
17	1	1	CD	CD	_	16	nummod	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	facilitates	facilitate	VBZ	VBZ	_	8	conj	_	_
20	actin	actin	NN	NN	_	21	compound	_	_
21	polymerization	polymerization	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	8	punct	_	_

1	Hence	hence	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	phosphorylation	phosphorylation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	linker	linker	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	3	nmod	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	only	only	RB	RB	_	9	cc:preconj	_	_
9	bridges	bridge	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TCR-associated	tcr-associated	JJ	JJ	_	12	amod	_	_
12	PTK	ptk	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	ZAP-70	zap-70	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	with	with	IN	IN	_	19	case	_	_
17	downstream	downstream	JJ	JJ	_	19	amod	_	_
18	effector	effector	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	9	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	but	but	CC	CC	_	9	cc	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	provides	provide	VBZ	VBZ	_	9	conj	_	_
24	a	a	DT	DT	_	25	det	_	_
25	scaffold	scaffold	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	integrate	integrate	VB	VB	_	25	acl	_	_
28	distinct	distinct	JJ	JJ	_	30	amod	_	_
29	signaling	signal	VBG	VBG	_	30	amod	_	_
30	complexes	complex	NNS	NNS	_	27	dobj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	regulate	regulate	VB	VB	_	23	advcl	_	_
33	T	t	NN	NN	_	35	compound	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	function	function	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	9	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Th1	th1	NN	NN	_	4	compound	_	_
4	development	development	NN	NN	_	1	nmod	_	_
5	mediated	mediate	VBN	VBN	_	1	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	GATA-3	gata-3	NN	NN	_	5	nmod	_	_
8	through	through	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	IL-4-independent	il-4-independent	JJ	JJ	_	11	amod	_	_
11	mechanism	mechanism	NN	NN	_	5	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Recently	recently	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	GATA-3	gata-3	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	auxpass	_	_
11	selectively	selectively	RB	RB	_	12	advmod	_	_
12	expressed	express	VBN	VBN	_	8	ccomp	_	_
13	in	in	IN	IN	_	18	case	_	_
14	Th2	th2	NN	NN	_	18	compound	_	_
15	but	but	CC	CC	_	14	cc	_	_
16	not	not	RB	RB	_	14	conj	_	_
17	Th1	th1	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	12	nmod	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	augment	augment	VB	VB	_	12	conj	_	_
22	Th2-specific	th2-specific	JJ	JJ	_	23	amod	_	_
23	cytokines	cytokine	NNS	NNS	_	21	dobj	_	_
24	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	loss	loss	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	GATA-3	gata-3	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	developing	develop	VBG	VBG	_	13	amod	_	_
12	Th1	th1	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	requires	require	VBZ	VBZ	_	4	ccomp	_	_
15	IL-12	il-12	NN	NN	_	16	compound	_	_
16	signaling	signaling	NN	NN	_	14	dobj	_	_
17	through	through	IN	IN	_	18	case	_	_
18	Stat4	stat4	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	does	do	VBZ	VBZ	_	23	aux	_	_
21	not	not	RB	RB	_	23	neg	_	_
22	simply	simply	RB	RB	_	23	advmod	_	_
23	result	result	VB	VB	_	14	conj	_	_
24	from	from	IN	IN	_	26	case	_	_
25	an	a	DT	DT	_	26	det	_	_
26	absence	absence	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	IL-4	il-4	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	GATA-3	gata-3	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	mark	_	_
11	directly	directly	RB	RB	_	12	advmod	_	_
12	repressing	repress	VBG	VBG	_	7	acl	_	_
13	Th1	th1	NN	NN	_	14	compound	_	_
14	development	development	NN	NN	_	12	dobj	_	_
15	distinct	distinct	JJ	JJ	_	7	amod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	positive	positive	JJ	JJ	_	19	amod	_	_
19	actions	action	NNS	NNS	_	15	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	Th2-specific	th2-specific	JJ	JJ	_	22	amod	_	_
22	cytokines	cytokine	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	GATA-3	gata-3	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	Th1	th1	NN	NN	_	4	compound	_	_
4	cytokines	cytokine	NNS	NNS	_	2	dobj	_	_
5	by	by	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	cell-intrinsic	cell-intrinsic	JJ	JJ	_	8	amod	_	_
8	mechanism	mechanism	NN	NN	_	2	nmod	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	dependent	dependent	JJ	JJ	_	8	acl:relcl	_	_
13	on	on	IN	IN	_	14	case	_	_
14	IL-4	il-4	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	involve	involve	VB	VB	_	12	conj	_	_
19	repression	repression	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	IL-12	il-12	NN	NN	_	22	compound	_	_
22	signaling	signaling	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	GATA-3	gata-3	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-12	il-12	NN	NN	_	7	compound	_	_
7	signaling	signaling	NN	NN	_	4	conj	_	_
8	are	be	VBP	VBP	_	10	cop	_	_
9	mutually	mutually	RB	RB	_	10	advmod	_	_
10	antagonistic	antagonistic	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	which	which	WDT	WDT	_	13	nsubj	_	_
13	facilitates	facilitate	VBZ	VBZ	_	10	ccomp	_	_
14	rapid	rapid	JJ	JJ	_	15	amod	_	_
15	dominance	dominance	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	one	one	CD	CD	_	18	nummod	_	_
18	pathway	pathway	NN	NN	_	15	nmod	_	_
19	during	during	IN	IN	_	22	case	_	_
20	early	early	JJ	JJ	_	22	amod	_	_
21	Th	th	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	13	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	producing	produce	VBG	VBG	_	13	advcl	_	_
25	a	a	DT	DT	_	27	det	_	_
26	stable	stable	JJ	JJ	_	27	amod	_	_
27	divergence	divergence	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	cytokine	cytokine	NN	NN	_	30	compound	_	_
30	profiles	profile	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	7	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	transforming	transform	VBG	VBG	_	1	conj	_	_
4	growth	growth	NN	NN	_	7	compound	_	_
5	factor-beta	factor-beta	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	polymorphisms	polymorphism	NNS	NNS	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	allergies	allergy	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	asthma	asthma	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	7	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	14	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-10	il-10	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	transforming	transform	VBG	VBG	_	9	amod	_	_
7	growth	growth	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	beta	beta	NN	NN	_	1	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TGF-beta	tgf-beta	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	inhibitory	inhibitory	JJ	JJ	_	0	root	_	_
15	for	for	IN	IN	_	19	case	_	_
16	B	b	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	T	t	NN	NN	_	16	conj	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	IgE	ige	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	mast	mast	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	proliferation	proliferation	NN	NN	_	19	conj	_	_
28	,	,	,	,	_	14	punct	_	_
29	and	and	CC	CC	_	14	cc	_	_
30	they	they	PRP	PRP	_	31	nsubj	_	_
31	induce	induce	VBP	VBP	_	14	conj	_	_
32	apoptosis	apoptosis	NN	NN	_	31	dobj	_	_
33	in	in	IN	IN	_	34	case	_	_
34	eosinophils	eosinophil	NNS	NNS	_	32	nmod	_	_
35	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cytokines	cytokine	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	therefore	therefore	RB	RB	_	6	advmod	_	_
5	candidate	candidate	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	0	root	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	could	could	MD	MD	_	9	aux	_	_
9	contribute	contribute	VB	VB	_	6	acl:relcl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	development	development	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	asthma	asthma	NN	NN	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	allergies	allergy	NNS	NNS	_	14	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	hypothesis	hypothesis	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	polymorphic	polymorphic	JJ	JJ	_	7	amod	_	_
7	nucleotides	nucleotide	NNS	NNS	_	16	nsubj	_	_
8	within	within	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	IL-10	il-10	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	TGF-beta	tgf-beta	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	promoters	promoter	NNS	NNS	_	10	conj	_	_
15	would	would	MD	MD	_	16	aux	_	_
16	link	link	VB	VB	_	4	ccomp	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	allergies	allergy	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	asthma	asthma	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	DNA	dna	NN	NN	_	10	nsubjpass	_	_
2	taken	take	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	4	case	_	_
4	families	family	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	an	a	DT	DT	_	8	det	_	_
7	asthmatic	asthmatic	JJ	JJ	_	8	amod	_	_
8	proband	proband	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	examined	examine	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	13	case	_	_
12	base	base	NN	NN	_	13	compound	_	_
13	exchanges	exchange	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	single-stranded	single-stranded	JJ	JJ	_	17	amod	_	_
16	conformational	conformational	JJ	JJ	_	17	amod	_	_
17	polymorphism	polymorphism	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SSCP	sscp	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	polymorphism	polymorphism	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IL-10	il-10	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	four	four	CD	CD	_	7	conj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	TGF-beta	tgf-beta	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	promoters	promoter	NNS	NNS	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	3	3	CD	CD	_	17	dep	_	_
25	in	in	IN	IN	_	26	case	_	_
26	TGF-beta1	tgf-beta1	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	24	cc	_	_
28	1	1	CD	CD	_	24	conj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	TGF-beta2	tgf-beta2	NN	NN	_	28	nmod	_	_
31	)	)	-RRB-	-RRB-	_	24	punct	_	_
32	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IL-10	il-10	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	polymorphism	polymorphism	NN	NN	_	11	nsubj	_	_
5	was	be	VBD	VBD	_	11	cop	_	_
6	a	a	DT	DT	_	11	det	_	_
7	C-to-A	c-to-a	JJ	JJ	_	11	amod	_	_
8	exchange	exchange	NN	NN	_	11	compound	_	_
9	571	571	CD	CD	_	11	nummod	_	_
10	base	base	NN	NN	_	11	compound	_	_
11	pairs	pair	NNS	NNS	_	0	root	_	_
12	upstream	upstream	JJ	JJ	_	17	advmod	_	_
13	from	from	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	translation	translation	NN	NN	_	17	compound	_	_
16	start	start	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	was	be	VBD	VBD	_	20	cop	_	_
20	present	present	JJ	JJ	_	11	conj	_	_
21	between	between	IN	IN	_	24	case	_	_
22	consensus	consensus	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	sequences	sequence	NNS	NNS	_	20	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	Sp1	sp1	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	elevated	elevated	JJ	JJ	_	30	amod	_	_
29	total	total	JJ	JJ	_	30	amod	_	_
30	serum	serum	NN	NN	_	26	conj	_	_
31	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	polymorphism	polymorphism	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	9	case	_	_
6	elevated	elevated	JJ	JJ	_	9	amod	_	_
7	total	total	JJ	JJ	_	9	amod	_	_
8	serum	serum	NN	NN	_	9	compound	_	_
9	IgE	ige	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	subjects	subject	NNS	NNS	_	9	nmod	_	_
12	heterozygotic	heterozygotic	JJ	JJ	_	11	amod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	homozygotic	homozygotic	JJ	JJ	_	12	conj	_	_
15	for	for	IN	IN	_	18	case	_	_
16	this	this	DT	DT	_	18	det	_	_
17	base	base	NN	NN	_	18	compound	_	_
18	exchange	exchange	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	p	p	NN	NN	_	21	dep	_	_
21	&lt;	&lt;	JJR	JJR	_	4	parataxis	_	_
22	0.009	0.009	CD	CD	_	21	nummod	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	base	base	NN	NN	_	3	compound	_	_
3	exchange	exchange	NN	NN	_	18	nsubj	_	_
4	at	at	IN	IN	_	5	case	_	_
5	-509	-509	CD	CD	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	from	from	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	initiation	initiation	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	5	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	TGF-beta	tgf-beta	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	5	nmod	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	linked	link	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	22	case	_	_
20	elevated	elevated	JJ	JJ	_	22	amod	_	_
21	total	total	JJ	JJ	_	22	amod	_	_
22	IgE	ige	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	25	punct	_	_
24	p	p	NN	NN	_	25	dep	_	_
25	&lt;	&lt;	JJR	JJR	_	18	parataxis	_	_
26	0.01	0.01	CD	CD	_	25	nummod	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	.	.	.	.	_	18	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	polymorphism	polymorphism	NN	NN	_	3	nsubj	_	_
3	represented	represent	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	C-to-T	c-to-t	JJ	JJ	_	7	amod	_	_
6	base	base	NN	NN	_	7	compound	_	_
7	exchange	exchange	NN	NN	_	3	dobj	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	induced	induce	VBD	VBD	_	7	acl:relcl	_	_
10	a	a	DT	DT	_	13	det	_	_
11	YY1	yy1	NN	NN	_	13	compound	_	_
12	consensus	consensus	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	9	dobj	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	present	present	JJ	JJ	_	9	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	region	region	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	promoter	promoter	NN	NN	_	19	nmod	_	_
23	associated	associate	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	27	case	_	_
25	negative	negative	JJ	JJ	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	regulation	regulation	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Accessing	access	VBG	VBG	_	0	root	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus-specific	virus-specific	JJ	JJ	_	5	amod	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	memory	memory	NN	NN	_	1	dobj	_	_
6	with	with	IN	IN	_	9	case	_	_
7	peptide-loaded	peptide-loaded	JJ	JJ	_	9	amod	_	_
8	dendritic	dendritic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	conventional	conventional	JJ	JJ	_	3	amod	_	_
3	means	means	NNS	NNS	_	35	nsubj	_	_
4	of	of	IN	IN	_	5	mark	_	_
5	studying	study	VBG	VBG	_	3	acl	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	11	nmod:npmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EBV	ebv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	-induced	-induced	JJ	JJ	_	17	amod	_	_
12	cytotoxic	cytotoxic	JJ	JJ	_	13	amod	_	_
13	T-lymphocyte	t-lymphocyte	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	CTL	ctl	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	memory	memory	NN	NN	_	5	dobj	_	_
18	,	,	,	,	_	5	punct	_	_
19	by	by	IN	IN	_	22	case	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	vitro	vitro	FW	FW	_	20	dep	_	_
22	stimulation	stimulation	NN	NN	_	5	nmod	_	_
23	with	with	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	det	_	_
25	latently	latently	RB	RB	_	26	advmod	_	_
26	infected	infected	JJ	JJ	_	30	amod	_	_
27	autologous	autologous	JJ	JJ	_	30	amod	_	_
28	lymphoblastoid	lymphoblastoid	JJ	JJ	_	30	amod	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	line	line	NN	NN	_	22	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	LCL	lcl	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	,	,	,	,	_	5	punct	_	_
35	has	have	VBZ	VBZ	_	0	root	_	_
36	important	important	JJ	JJ	_	37	amod	_	_
37	limitations	limitation	NNS	NNS	_	35	dobj	_	_
38	.	.	.	.	_	35	punct	_	_

1	First	first	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	gives	give	VBZ	VBZ	_	0	root	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	information	information	NN	NN	_	4	dobj	_	_
7	on	on	IN	IN	_	8	case	_	_
8	memory	memory	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	lytic	lytic	JJ	JJ	_	12	amod	_	_
11	cycle	cycle	NN	NN	_	12	compound	_	_
12	antigens	antigen	NNS	NNS	_	4	nmod	_	_
13	;	;	:	:	_	4	punct	_	_
14	second	second	RB	RB	_	18	advmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	it	it	PRP	PRP	_	18	nsubj	_	_
17	preferentially	preferentially	RB	RB	_	18	advmod	_	_
18	amplifies	amplify	VBZ	VBZ	_	4	parataxis	_	_
19	the	the	DT	DT	_	21	det	_	_
20	dominant	dominant	JJ	JJ	_	21	amod	_	_
21	components	component	NNS	NNS	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	latent	latent	JJ	JJ	_	25	amod	_	_
24	antigen-specific	antigen-specific	JJ	JJ	_	25	amod	_	_
25	memory	memory	NN	NN	_	21	nmod	_	_
26	at	at	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	expense	expense	NN	NN	_	18	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	key	key	JJ	JJ	_	32	amod	_	_
31	subdominant	subdominant	JJ	JJ	_	32	amod	_	_
32	reactivities	reactivity	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	alternative	alternative	JJ	JJ	_	6	amod	_	_
6	approach	approach	NN	NN	_	3	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	based	base	VBN	VBN	_	12	case	_	_
9	on	on	IN	IN	_	12	case	_	_
10	in	in	FW	FW	_	12	amod	_	_
11	vitro	vitro	FW	FW	_	10	dep	_	_
12	stimulation	stimulation	NN	NN	_	6	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	epitope	epitope	NN	NN	_	17	compound	_	_
15	peptide-loaded	peptide-loaded	JJ	JJ	_	17	amod	_	_
16	dendritic	dendritic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	DCs	dc	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	6	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	allows	allow	VBZ	VBZ	_	6	acl:relcl	_	_
24	one	one	PRP	PRP	_	23	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	probe	probe	VB	VB	_	23	xcomp	_	_
27	the	the	DT	DT	_	29	det	_	_
28	CTL	ctl	NN	NN	_	29	compound	_	_
29	repertoire	repertoire	NN	NN	_	26	dobj	_	_
30	for	for	IN	IN	_	33	case	_	_
31	any	any	DT	DT	_	33	det	_	_
32	individual	individual	JJ	JJ	_	33	amod	_	_
33	reactivity	reactivity	NN	NN	_	26	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	choice	choice	NN	NN	_	33	nmod	_	_
36	;	;	:	:	_	3	punct	_	_
37	this	this	DT	DT	_	38	det	_	_
38	method	method	NN	NN	_	39	nsubj	_	_
39	proved	prove	VBD	VBD	_	3	parataxis	_	_
40	significantly	significantly	RB	RB	_	42	advmod	_	_
41	more	more	RBR	RBR	_	42	advmod	_	_
42	efficient	efficient	JJ	JJ	_	39	xcomp	_	_
43	than	than	IN	IN	_	44	case	_	_
44	stimulation	stimulation	NN	NN	_	42	nmod	_	_
45	with	with	IN	IN	_	46	case	_	_
46	peptide	peptide	NN	NN	_	44	nmod	_	_
47	alone	alone	RB	RB	_	46	advmod	_	_
48	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	6	dep	_	_
2	this	this	DT	DT	_	3	det	_	_
3	approach	approach	NN	NN	_	1	dobj	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	first	first	RB	RB	_	6	advmod	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	27	mark	_	_
8	reactivities	reactivity	NNS	NNS	_	27	nsubj	_	_
9	to	to	TO	TO	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	immunodominant	immunodominant	JJ	JJ	_	16	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	subdominant	subdominant	JJ	JJ	_	11	conj	_	_
14	lytic	lytic	JJ	JJ	_	16	amod	_	_
15	cycle	cycle	NN	NN	_	16	compound	_	_
16	epitopes	epitope	NNS	NNS	_	8	nmod	_	_
17	identified	identify	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	during	during	IN	IN	_	24	case	_	_
22	primary	primary	JJ	JJ	_	24	amod	_	_
23	EBV	ebv	NN	NN	_	24	compound	_	_
24	infection	infection	NN	NN	_	17	nmod	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	regularly	regularly	RB	RB	_	27	advmod	_	_
27	detectable	detectable	JJ	JJ	_	6	ccomp	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	CTL	ctl	NN	NN	_	31	compound	_	_
31	memory	memory	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	virus	virus	NN	NN	_	34	compound	_	_
34	carriers	carrier	NNS	NNS	_	31	nmod	_	_
35	;	;	:	:	_	6	punct	_	_
36	this	this	DT	DT	_	37	nsubj	_	_
37	implies	imply	VBZ	VBZ	_	6	parataxis	_	_
38	that	that	IN	IN	_	45	mark	_	_
39	in	in	IN	IN	_	41	case	_	_
40	such	such	JJ	JJ	_	41	amod	_	_
41	carriers	carrier	NNS	NNS	_	45	nmod	_	_
42	chronic	chronic	JJ	JJ	_	44	amod	_	_
43	virus	virus	NN	NN	_	44	compound	_	_
44	replication	replication	NN	NN	_	45	nsubj	_	_
45	remains	remain	VBZ	VBZ	_	37	ccomp	_	_
46	under	under	IN	IN	_	49	case	_	_
47	direct	direct	JJ	JJ	_	49	amod	_	_
48	T-cell	t-cell	NN	NN	_	49	compound	_	_
49	control	control	NN	NN	_	45	nmod	_	_
50	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	27	mark	_	_
5	subdominant	subdominant	JJ	JJ	_	8	amod	_	_
6	latent	latent	JJ	JJ	_	8	amod	_	_
7	cycle	cycle	NN	NN	_	8	compound	_	_
8	reactivities	reactivity	NNS	NNS	_	27	nsubjpass	_	_
9	to	to	TO	TO	_	10	case	_	_
10	epitopes	epitope	NNS	NNS	_	8	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	latent	latent	JJ	JJ	_	16	amod	_	_
14	membrane	membrane	NN	NN	_	16	compound	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	LMP2	lmp2	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	27	punct	_	_
18	though	though	IN	IN	_	20	mark	_	_
19	rarely	rarely	RB	RB	_	20	dep	_	_
20	undetectable	undetectable	JJ	JJ	_	27	dep	_	_
21	in	in	IN	IN	_	23	case	_	_
22	LCL-stimulated	lcl-stimulated	JJ	JJ	_	23	amod	_	_
23	populations	population	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	27	punct	_	_
25	can	can	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	auxpass	_	_
27	reactivated	reactivate	VBN	VBN	_	3	ccomp	_	_
28	by	by	IN	IN	_	30	case	_	_
29	DC	dc	NN	NN	_	30	compound	_	_
30	stimulation	stimulation	NN	NN	_	27	nmod	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	selectively	selectively	RB	RB	_	33	advmod	_	_
33	expanded	expand	VBN	VBN	_	27	conj	_	_
34	as	as	IN	IN	_	37	case	_	_
35	polyclonal	polyclonal	JJ	JJ	_	37	amod	_	_
36	CTL	ctl	NN	NN	_	37	compound	_	_
37	lines	line	NNS	NNS	_	33	nmod	_	_
38	;	;	:	:	_	3	punct	_	_
39	the	the	DT	DT	_	41	det	_	_
40	adoptive	adoptive	JJ	JJ	_	41	amod	_	_
41	transfer	transfer	NN	NN	_	48	nsubj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	such	such	JJ	JJ	_	44	amod	_	_
44	preparations	preparation	NNS	NNS	_	41	nmod	_	_
45	may	may	MD	MD	_	48	aux	_	_
46	be	be	VB	VB	_	48	cop	_	_
47	of	of	IN	IN	_	48	case	_	_
48	value	value	NN	NN	_	3	parataxis	_	_
49	in	in	IN	IN	_	50	mark	_	_
50	targeting	target	VBG	VBG	_	48	advcl	_	_
51	certain	certain	JJ	JJ	_	53	amod	_	_
52	EBV-positive	ebv-positive	JJ	JJ	_	53	amod	_	_
53	malignancies	malignancy	NNS	NNS	_	50	dobj	_	_
54	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	on	on	IN	IN	_	5	case	_	_
4	mononuclear	mononuclear	JJ	JJ	_	5	amod	_	_
5	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	polycystic	polycystic	JJ	JJ	_	9	amod	_	_
8	ovary	ovary	JJ	JJ	_	9	amod	_	_
9	syndrome	syndrome	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Many	many	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	suggested	suggest	VBN	VBN	_	1	appos	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	there	there	EX	EX	_	9	expl	_	_
9	is	be	VBZ	VBZ	_	6	ccomp	_	_
10	a	a	DT	DT	_	13	det	_	_
11	possible	possible	JJ	JJ	_	13	amod	_	_
12	hormonal	hormonal	JJ	JJ	_	13	amod	_	_
13	dysregulation	dysregulation	NN	NN	_	9	nsubj	_	_
14	of	of	IN	IN	_	19	case	_	_
15	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	19	amod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	HPA	hpa	JJ	JJ	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	axis	axis	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	an	a	DT	DT	_	24	det	_	_
22	increased	increase	VBN	VBN	_	24	amod	_	_
23	cortisol	cortisol	NN	NN	_	24	compound	_	_
24	clearance	clearance	NN	NN	_	13	conj	_	_
25	in	in	IN	IN	_	26	case	_	_
26	patients	patient	NNS	NNS	_	24	nmod	_	_
27	with	with	IN	IN	_	30	case	_	_
28	polycystic	polycystic	JJ	JJ	_	30	amod	_	_
29	ovary	ovary	JJ	JJ	_	30	amod	_	_
30	syndrome	syndrome	NN	NN	_	26	nmod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	PCOS	pcos	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	1	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	in	in	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	examined	examine	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	17	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	receptor/s	receptor/s	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GR	gr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	characteristics	characteristic	NNS	NNS	_	10	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	developing	developing	NN	NN	_	10	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	these	these	DT	DT	_	23	det	_	_
23	abnormalities	abnormality	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	patients	patient	NNS	NNS	_	23	nmod	_	_
26	with	with	IN	IN	_	27	case	_	_
27	PCOS	pcos	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	METHOD	method	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	For	for	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	purpose	purpose	NN	NN	_	33	nmod	_	_
6	,	,	,	,	_	33	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	33	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	affinity	affinity	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	GR	gr	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	leukocytes	leukocyte	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	MNL	mnl	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	of	of	IN	IN	_	22	case	_	_
21	10	10	CD	CD	_	22	nummod	_	_
22	patients	patient	NNS	NNS	_	16	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	PCOS	pcos	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	10	10	CD	CD	_	28	nummod	_	_
27	healthy	healthy	JJ	JJ	_	28	amod	_	_
28	women	woman	NNS	NNS	_	22	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	controls	control	NNS	NNS	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	determined	determine	VBN	VBN	_	1	appos	_	_
34	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	There	there	EX	EX	_	4	expl	_	_
4	were	be	VBD	VBD	_	1	appos	_	_
5	no	no	DT	DT	_	7	neg	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	differences	difference	NNS	NNS	_	4	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	21	punct	_	_
12	6500+/-1001	6500+/-1001	CD	CD	_	13	nummod	_	_
13	sites/cell	sites/cell	NNS	NNS	_	21	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	6352+/-1697	6352+/-1697	CD	CD	_	16	nummod	_	_
16	sites/cell	sites/cell	NNS	NNS	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	respectively	respectively	RB	RB	_	13	advmod	_	_
19	;	;	:	:	_	21	punct	_	_
20	P	p	NN	NN	_	21	dep	_	_
21	&gt;	&gt;	JJR	JJR	_	10	dep	_	_
22	0.05	0.05	CD	CD	_	21	nummod	_	_
23	)	)	-RRB-	-RRB-	_	21	punct	_	_
24	and	and	CC	CC	_	10	cc	_	_
25	affinity	affinity	NN	NN	_	10	conj	_	_
26	(	(	-LRB-	-LRB-	_	36	punct	_	_
27	3.93+/-0.89	3.93+/-0.89	CD	CD	_	28	nummod	_	_
28	nM	nm	NN	NN	_	36	dep	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	4.49+/-0.71	4.49+/-0.71	CD	CD	_	31	nummod	_	_
31	nM	nm	NN	NN	_	28	conj	_	_
32	,	,	,	,	_	28	punct	_	_
33	respectively	respectively	RB	RB	_	28	advmod	_	_
34	;	;	:	:	_	36	punct	_	_
35	P	p	NN	NN	_	36	dep	_	_
36	&gt;	&gt;	JJR	JJR	_	25	dep	_	_
37	0.05	0.05	CD	CD	_	36	nummod	_	_
38	)	)	-RRB-	-RRB-	_	36	punct	_	_
39	of	of	IN	IN	_	40	case	_	_
40	GR	gr	NN	NN	_	10	nmod	_	_
41	between	between	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	PCOS	pcos	NN	NN	_	44	compound	_	_
44	patients	patient	NNS	NNS	_	7	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	the	the	DT	DT	_	47	det	_	_
47	controls	control	NNS	NNS	_	44	conj	_	_
48	.	.	.	.	_	1	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	appos	_	_
6	that	that	IN	IN	_	23	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	alterations	alteration	NNS	NNS	_	23	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	HPA	hpa	JJ	JJ	_	12	amod	_	_
12	axis	axis	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cortisol	cortisol	NN	NN	_	17	compound	_	_
17	metabolism	metabolism	NN	NN	_	12	conj	_	_
18	observed	observe	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	20	case	_	_
20	PCOS	pcos	NN	NN	_	18	nmod	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	related	related	JJ	JJ	_	5	ccomp	_	_
24	to	to	TO	TO	_	26	case	_	_
25	GR	gr	NN	NN	_	26	compound	_	_
26	deficiency	deficiency	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	association	association	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	JAK1	jak1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	STAT5	stat5	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	pro-B	pro-b	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	dissolved	dissolve	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	interleukin-4-induced	interleukin-4-induced	JJ	JJ	_	15	amod	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	DT	DT	_	18	det	_	_
18	proteins	protein	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	bipartite	bipartite	JJ	JJ	_	8	amod	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	interleukin-4	interleukin-4	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	IL-4	il-4	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	receptor	receptor	NN	NN	_	11	nsubjpass	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	functionally	functionally	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	murine	murine	JJ	JJ	_	15	amod	_	_
14	pro-B	pro-b	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	activated	activate	VBN	VBN	_	11	conj	_	_
18	by	by	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	IL-4	il-4	NN	NN	_	17	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	evoke	evoke	VB	VB	_	17	xcomp	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	signaling	signaling	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	11	punct	_	_

1	Mutual	mutual	JJ	JJ	_	2	amod	_	_
2	association	association	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	signal	signal	NN	NN	_	6	compound	_	_
5	transducing	transducing	NN	NN	_	6	compound	_	_
6	proteins	protein	NNS	NNS	_	2	nmod	_	_
7	within	within	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	6	nmod	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	then	then	RB	RB	_	13	advmod	_	_
13	studied	study	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	15	case	_	_
15	dependence	dependence	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	ligand	ligand	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Besides	besides	IN	IN	_	4	case	_	_
2	ligand-induced	ligand-induced	JJ	JJ	_	4	amod	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	heterodimerization	heterodimerization	NN	NN	_	37	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	contacts	contact	NNS	NNS	_	4	conj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	two	two	CD	CD	_	12	nummod	_	_
10	IL-4	il-4	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	subunits	subunit	NNS	NNS	_	6	nmod	_	_
13	alpha	alpha	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	gamma	gamma	NN	NN	_	13	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	Janus	janus	NN	NN	_	18	compound	_	_
18	kinases	kinase	NNS	NNS	_	6	nmod	_	_
19	JAK1	jak1	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	JAK3	jak3	NN	NN	_	19	conj	_	_
22	a	a	DT	DT	_	25	det	_	_
23	prominent	prominent	JJ	JJ	_	25	amod	_	_
24	constitutive	constitutive	JJ	JJ	_	25	amod	_	_
25	binding	binding	NN	NN	_	37	nsubjpass	_	_
26	between	between	IN	IN	_	27	case	_	_
27	JAK1	jak1	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	signal	signal	NN	NN	_	30	compound	_	_
30	transducer	transducer	NN	NN	_	27	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	activator	activator	NN	NN	_	35	compound	_	_
33	of	of	IN	IN	_	35	amod	_	_
34	transcription	transcription	NN	NN	_	35	compound	_	_
35	STAT5	stat5	NN	NN	_	30	conj	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	detected	detect	VBN	VBN	_	0	root	_	_
38	.	.	.	.	_	37	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	both	both	DT	DT	_	4	det:predet	_	_
3	these	these	DT	DT	_	4	det	_	_
4	proteins	protein	NNS	NNS	_	5	nsubj	_	_
5	become	become	VBP	VBP	_	24	advcl	_	_
6	phosphorylated	phosphorylate	VBN	VBN	_	5	xcomp	_	_
7	in	in	IN	IN	_	12	case	_	_
8	response	response	NN	NN	_	12	dep	_	_
9	to	to	TO	TO	_	12	case	_	_
10	IL-4	il-4	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	5	nmod	_	_
13	,	,	,	,	_	24	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	influence	influence	NN	NN	_	24	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	22	case	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	mutual	mutual	JJ	JJ	_	22	amod	_	_
22	contact	contact	NN	NN	_	15	nmod	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	analyzed	analyze	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Association	association	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	JAK1	jak1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	STAT5	stat5	NN	NN	_	3	conj	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	occur	occur	VB	VB	_	7	xcomp	_	_
10	exclusively	exclusively	RB	RB	_	13	advmod	_	_
11	between	between	IN	IN	_	13	case	_	_
12	unphosphorylated	unphosphorylated	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	linkage	linkage	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	8	case	_	_
4	T-cell	t-cell	NN	NN	_	8	compound	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	dendritic	dendritic	JJ	JJ	_	4	conj	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	mouse	mouse	NN	NN	_	12	compound	_	_
12	thymus	thymus	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Thymic	thymic	JJ	JJ	_	3	amod	_	_
2	dendritic	dendritic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	DC	dc	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	mediate	mediate	VBP	VBP	_	0	root	_	_
8	negative	negative	JJ	JJ	_	9	amod	_	_
9	selection	selection	NN	NN	_	7	dobj	_	_
10	at	at	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	relatively	relatively	RB	RB	_	13	advmod	_	_
13	late	late	JJ	JJ	_	14	amod	_	_
14	stage	stage	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	developmental	developmental	JJ	JJ	_	19	amod	_	_
19	pathway	pathway	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	development	development	NN	NN	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	thymic	thymic	JJ	JJ	_	9	amod	_	_
9	DC	dc	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	of	of	IN	IN	_	13	case	_	_
12	T-lineage	t-lineage	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	conj	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	linked	link	VBN	VBN	_	3	ccomp	_	_
16	via	via	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	common	common	JJ	JJ	_	19	amod	_	_
19	precursor	precursor	NN	NN	_	15	nmod	_	_
20	at	at	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	early	early	JJ	JJ	_	23	amod	_	_
23	stage	stage	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	thymocyte	thymocyte	NN	NN	_	26	compound	_	_
26	development	development	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	T-lineage	t-lineage	NN	NN	_	3	compound	_	_
2	precursor	precursor	NN	NN	_	3	compound	_	_
3	populations	population	NNS	NNS	_	17	nsubj	_	_
4	from	from	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	adult	adult	JJ	JJ	_	8	amod	_	_
7	mouse	mouse	NN	NN	_	8	compound	_	_
8	thymus	thymus	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	prior	prior	JJ	JJ	_	15	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	T-cell	t-cell	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	rearrangement	rearrangement	NN	NN	_	17	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	display	display	VBP	VBP	_	0	root	_	_
18	a	a	DT	DT	_	19	det	_	_
19	capacity	capacity	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	produce	produce	VB	VB	_	19	acl	_	_
22	DC	dc	NNS	NNS	_	27	compound	_	_
23	as	as	RB	RB	_	27	advmod	_	_
24	well	well	RB	RB	_	27	advmod	_	_
25	as	as	IN	IN	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	21	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	thymus	thymus	NN	NN	_	21	nmod	_	_
31	,	,	,	,	_	17	punct	_	_
32	and	and	CC	CC	_	17	cc	_	_
33	are	be	VBP	VBP	_	36	cop	_	_
34	very	very	RB	RB	_	35	advmod	_	_
35	efficient	efficient	JJ	JJ	_	36	amod	_	_
36	precursors	precursor	NNS	NNS	_	17	conj	_	_
37	of	of	IN	IN	_	38	case	_	_
38	DC	dc	NNS	NNS	_	36	nmod	_	_
39	in	in	IN	IN	_	40	case	_	_
40	culture	culture	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	lymphoid/DC	lymphoid/dc	JJ	JJ	_	3	amod	_	_
3	precursors	precursor	NNS	NNS	_	4	nsubj	_	_
4	have	have	VBP	VBP	_	0	root	_	_
5	little	little	JJ	JJ	_	6	amod	_	_
6	capacity	capacity	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	form	form	VB	VB	_	6	acl	_	_
9	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	8	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	indicating	indicate	VBG	VBG	_	4	advcl	_	_
13	that	that	IN	IN	_	22	mark	_	_
14	thymic	thymic	JJ	JJ	_	15	amod	_	_
15	DC	dc	NNS	NNS	_	22	nsubj	_	_
16	are	be	VBP	VBP	_	22	cop	_	_
17	a	a	DT	DT	_	22	det	_	_
18	lymphoid-related	lymphoid-related	JJ	JJ	_	22	amod	_	_
19	rather	rather	RB	RB	_	18	cc	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	myeloid-related	myeloid-related	JJ	JJ	_	18	conj	_	_
22	lineage	lineage	NN	NN	_	12	ccomp	_	_
23	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	contrast	contrast	NN	NN	_	5	dep	_	_
3	to	to	TO	TO	_	5	case	_	_
4	myeloid-related	myeloid-related	JJ	JJ	_	5	amod	_	_
5	DC	dc	NNS	NNS	_	12	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	9	amod	_	_
8	colony-stimulating	colony-stimulating	JJ	JJ	_	9	amod	_	_
9	factor	factor	NN	NN	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	required	require	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	development	development	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	these	these	DT	DT	_	19	det	_	_
18	lymphoid-related	lymphoid-related	JJ	JJ	_	19	amod	_	_
19	DC	dc	NNS	NNS	_	15	nmod	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	22	advmod	_	_
22	or	or	CC	CC	_	12	advmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	22	advmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	DC	dc	NNS	NNS	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	develop	develop	VB	VB	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	mutant	mutant	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	3	nmod	_	_
7	lacking	lack	VBG	VBG	_	6	acl	_	_
8	mature	mature	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	dobj	_	_
11	,	,	,	,	_	3	punct	_	_
12	provided	provide	VBN	VBN	_	17	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	common	common	JJ	JJ	_	15	amod	_	_
15	precursors	precursor	NNS	NNS	_	17	nsubj	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	present	present	JJ	JJ	_	3	advcl	_	_
18	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	in	in	IN	IN	_	5	case	_	_
4	mutant	mutant	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	13	nmod	_	_
6	lacking	lack	VBG	VBG	_	5	acl	_	_
7	functional	functional	JJ	JJ	_	10	amod	_	_
8	Ikaros	ikaros	NN	NN	_	10	compound	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	6	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	there	there	EX	EX	_	13	expl	_	_
13	are	be	VBP	VBP	_	0	root	_	_
14	deficiencies	deficiency	NNS	NNS	_	13	nsubj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
17	precursor	precursor	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	in	in	IN	IN	_	23	case	_	_
21	mature	mature	JJ	JJ	_	23	amod	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	18	conj	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	in	in	IN	IN	_	26	case	_	_
26	DC	dc	NNS	NNS	_	18	conj	_	_
27	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	involvement	involvement	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	13	case	_	_
4	multiple	multiple	JJ	JJ	_	13	amod	_	_
5	tumor	tumor	NN	NN	_	13	compound	_	_
6	necrosis	necrosis	NN	NN	_	13	compound	_	_
7	factor	factor	NN	NN	_	13	compound	_	_
8	receptor	receptor	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	TNFR	tnfr	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	-associated	-associated	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	2	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	signaling	signaling	NN	NN	_	17	compound	_	_
17	mechanisms	mechanism	NNS	NNS	_	2	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	activator	activator	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	a	a	DT	DT	_	25	det	_	_
25	member	member	NN	NN	_	22	appos	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	TNFR	tnfr	NN	NN	_	29	compound	_	_
29	superfamily	superfamily	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Receptor	receptor	NN	NN	_	4	compound	_	_
2	activator	activator	NN	NN	_	4	compound	_	_
3	of	of	IN	IN	_	4	amod	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	RANK	rank	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	recently	recently	RB	RB	_	11	advmod	_	_
11	identified	identify	VBN	VBN	_	12	amod	_	_
12	member	member	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	tumor	tumor	NN	NN	_	19	compound	_	_
16	necrosis	necrosis	NN	NN	_	19	compound	_	_
17	factor	factor	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	superfamily	superfamily	NN	NN	_	12	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	12	conj	_	_
23	on	on	IN	IN	_	26	case	_	_
24	activated	activate	VBN	VBN	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	dendritic	dendritic	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	conj	_	_
30	.	.	.	.	_	12	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	cognate	cognate	JJ	JJ	_	3	amod	_	_
3	ligand	ligand	NN	NN	_	7	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	RANKL	rankl	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	plays	play	VBZ	VBZ	_	0	root	_	_
8	significant	significant	JJ	JJ	_	9	amod	_	_
9	roles	role	NNS	NNS	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	dendritic	dendritic	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	function	function	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	osteoclast	osteoclast	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	interaction	interaction	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	RANK	rank	NN	NN	_	5	nmod	_	_
8	with	with	IN	IN	_	13	case	_	_
9	tumor	tumor	NN	NN	_	12	nmod:npmod	_	_
10	necrosis	necrosis	NN	NN	_	12	nmod:npmod	_	_
11	factor	factor	NN	NN	_	12	nmod:npmod	_	_
12	receptor-associated	receptor-associated	JJ	JJ	_	13	amod	_	_
13	factors	factor	NNS	NNS	_	5	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TRAFs	traf	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	1	1	CD	CD	_	13	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	2	2	CD	CD	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	3	3	CD	CD	_	17	conj	_	_
22	,	,	,	,	_	17	punct	_	_
23	5	5	CD	CD	_	17	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	6	6	CD	CD	_	17	conj	_	_
27	both	both	CC	CC	_	2	dep	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vitro	vitro	FW	FW	_	27	dep	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	in	in	IN	IN	_	32	case	_	_
32	cells	cell	NNS	NNS	_	27	conj	_	_
33	.	.	.	.	_	2	punct	_	_

1	Mapping	mapping	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	structural	structural	JJ	JJ	_	5	amod	_	_
5	requirements	requirement	NNS	NNS	_	1	nmod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	TRAF/RANK	traf/rank	NN	NN	_	8	compound	_	_
8	interaction	interaction	NN	NN	_	5	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	multiple	multiple	JJ	JJ	_	13	amod	_	_
11	TRAF	traf	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	9	dobj	_	_
14	clustered	cluster	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	two	two	CD	CD	_	18	nummod	_	_
17	distinct	distinct	JJ	JJ	_	18	amod	_	_
18	domains	domain	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	RANK	rank	NN	NN	_	23	compound	_	_
22	cytoplasmic	cytoplasmic	JJ	JJ	_	23	amod	_	_
23	tail	tail	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	TRAF	traf	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	domains	domain	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	10	mark	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	functionally	functionally	RB	RB	_	10	advmod	_	_
10	important	important	JJ	JJ	_	6	xcomp	_	_
11	for	for	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	RANK-dependent	rank-dependent	JJ	JJ	_	14	amod	_	_
14	induction	induction	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	21	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	c-Jun	c-jun	NN	NN	_	16	conj	_	_
19	NH2-terminal	nh2-terminal	JJ	JJ	_	21	amod	_	_
20	kinase	kinase	NN	NN	_	21	compound	_	_
21	activities	activity	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	these	these	DT	DT	_	8	det	_	_
6	TRAF	traf	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	9	nsubj	_	_
9	exhibited	exhibit	VBD	VBD	_	3	ccomp	_	_
10	selective	selective	JJ	JJ	_	11	amod	_	_
11	binding	binding	NN	NN	_	9	dobj	_	_
12	for	for	IN	IN	_	15	case	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	TRAF	traf	NN	NN	_	15	compound	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	TRAF6	traf6	NN	NN	_	5	nsubj	_	_
5	interacted	interact	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	membrane-proximal	membrane-proximal	JJ	JJ	_	8	amod	_	_
8	determinants	determinant	NNS	NNS	_	5	nmod	_	_
9	distinct	distinct	JJ	JJ	_	8	amod	_	_
10	from	from	IN	IN	_	13	case	_	_
11	those	those	DT	DT	_	13	det	_	_
12	binding	bind	VBG	VBG	_	13	amod	_	_
13	TRAFs	traf	NNS	NNS	_	9	nmod	_	_
14	1	1	CD	CD	_	13	dep	_	_
15	,	,	,	,	_	14	punct	_	_
16	2	2	CD	CD	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	3	3	CD	CD	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	5	5	CD	CD	_	14	conj	_	_
22	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	8	advmod	_	_
2	this	this	DT	DT	_	6	det	_	_
3	membrane-proximal	membrane-proximal	JJ	JJ	_	6	amod	_	_
4	TRAF6	traf6	NN	NN	_	6	compound	_	_
5	interaction	interaction	NN	NN	_	6	compound	_	_
6	domain	domain	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	deleted	delete	VBN	VBN	_	15	advcl	_	_
9	,	,	,	,	_	15	punct	_	_
10	RANK-mediated	rank-mediated	JJ	JJ	_	12	amod	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	15	nsubjpass	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	completely	completely	RB	RB	_	15	advmod	_	_
15	inhibited	inhibit	VBN	VBN	_	0	root	_	_
16	while	while	IN	IN	_	23	mark	_	_
17	c-Jun	c-jun	NN	NN	_	20	compound	_	_
18	NH2-terminal	nh2-terminal	JJ	JJ	_	20	amod	_	_
19	kinase	kinase	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	23	nsubjpass	_	_
21	was	be	VBD	VBD	_	23	auxpass	_	_
22	partially	partially	RB	RB	_	23	advmod	_	_
23	inhibited	inhibit	VBN	VBN	_	15	advcl	_	_
24	.	.	.	.	_	15	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	NH2-terminal	nh2-terminal	JJ	JJ	_	4	amod	_	_
3	truncation	truncation	NN	NN	_	4	compound	_	_
4	mutant	mutant	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	TRAF6	traf6	NN	NN	_	4	nmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	RANKL-mediated	rankl-mediated	JJ	JJ	_	10	amod	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	but	but	CC	CC	_	7	cc	_	_
13	failed	fail	VBD	VBD	_	7	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	affect	affect	VB	VB	_	13	xcomp	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	signaling	signaling	NN	NN	_	15	dobj	_	_
18	induced	induce	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	overexpression	overexpression	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	revealing	reveal	VBG	VBG	_	13	xcomp	_	_
24	a	a	DT	DT	_	26	det	_	_
25	selective	selective	JJ	JJ	_	26	amod	_	_
26	role	role	NN	NN	_	23	dobj	_	_
27	for	for	IN	IN	_	28	case	_	_
28	TRAF6	traf6	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	ligand-induced	ligand-induced	JJ	JJ	_	32	amod	_	_
31	activation	activation	NN	NN	_	32	compound	_	_
32	events	event	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	control	control	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	lytic	lytic	JJ	JJ	_	5	amod	_	_
5	replication	replication	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Review	review	NN	NN	_	2	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	2	punct	_	_

1	Uncontrolled	uncontrolled	JJ	JJ	_	2	amod	_	_
2	replication	replication	NN	NN	_	15	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	a	a	DT	DT	_	5	det	_	_
5	virus	virus	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	harmful	harmful	JJ	JJ	_	5	acl:relcl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	host	host	NN	NN	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	15	cop	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	disadvantageous	disadvantageous	JJ	JJ	_	0	root	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	virus	virus	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	viruses	virus	NNS	NNS	_	5	nsubj	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	compete	compete	VB	VB	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	various	various	JJ	JJ	_	10	amod	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	mechanisms	mechanism	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	become	become	VBP	VBP	_	5	conj	_	_
13	eliminated	eliminate	VBN	VBN	_	12	xcomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	course	course	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	infection	infection	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Therefore	therefore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	only	only	RB	RB	_	5	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	time	time	NN	NN	_	10	nsubj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	infection	infection	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	eradication	eradication	NN	NN	_	7	conj	_	_
10	remains	remain	VBZ	VBZ	_	0	root	_	_
11	for	for	IN	IN	_	15	mark	_	_
12	these	these	DT	DT	_	13	det	_	_
13	viruses	virus	NNS	NNS	_	15	nsubj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	proliferate	proliferate	VB	VB	_	10	advcl	_	_
16	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	few	few	JJ	JJ	_	3	amod	_	_
3	viruses	virus	NNS	NNS	_	15	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	like	like	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	Herpesviruses	herpesvirus	NNS	NNS	_	3	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	10	det	_	_
10	papillomaviruses	papillomavirus	NNS	NNS	_	7	conj	_	_
11	,	,	,	,	_	15	punct	_	_
12	however	however	RB	RB	_	15	advmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	developed	develop	VBN	VBN	_	0	root	_	_
16	a	a	DT	DT	_	18	det	_	_
17	sophisticated	sophisticated	JJ	JJ	_	18	amod	_	_
18	strategy	strategy	NN	NN	_	15	dobj	_	_
19	for	for	IN	IN	_	20	mark	_	_
20	persisting	persist	VBG	VBG	_	18	acl	_	_
21	lifelong	lifelong	RB	RB	_	20	advmod	_	_
22	,	,	,	,	_	20	punct	_	_
23	usually	usually	RB	RB	_	24	advmod	_	_
24	asymptomatically	asymptomatically	RB	RB	_	20	advmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	dep	_	_
27	host	host	NN	NN	_	24	advcl	_	_
28	,	,	,	,	_	20	punct	_	_
29	hiding	hide	VBG	VBG	_	20	ccomp	_	_
30	from	from	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	immune	immune	JJ	JJ	_	33	amod	_	_
33	system	system	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	producing	produce	VBG	VBG	_	29	conj	_	_
36	infectious	infectious	JJ	JJ	_	37	amod	_	_
37	progeny	progeny	NN	NN	_	35	dobj	_	_
38	at	at	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	same	same	JJ	JJ	_	41	amod	_	_
41	time	time	NN	NN	_	29	nmod	_	_
42	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	strategy	strategy	NN	NN	_	3	nsubj	_	_
3	depends	depend	VBZ	VBZ	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	separation	separation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	latency	latency	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	lytic	lytic	JJ	JJ	_	12	amod	_	_
12	replication	replication	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	either	either	CC	CC	_	16	cc:preconj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	time	time	NN	NN	_	6	nmod	_	_
17	due	due	JJ	JJ	_	20	case	_	_
18	to	to	TO	TO	_	17	mwe	_	_
19	differentiation-dependent	differentiation-dependent	JJ	JJ	_	20	amod	_	_
20	mechanisms	mechanism	NNS	NNS	_	16	nmod	_	_
21	or	or	CC	CC	_	16	cc	_	_
22	by	by	IN	IN	_	24	case	_	_
23	spatial	spatial	JJ	JJ	_	24	amod	_	_
24	separation	separation	NN	NN	_	16	conj	_	_
25	as	as	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	result	result	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	different	different	JJ	JJ	_	32	amod	_	_
30	host	host	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	types	type	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Both	both	DT	DT	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	cop	_	_
3	true	true	JJ	JJ	_	0	root	_	_
4	for	for	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EBV	ebv	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	.	.	.	.	_	3	punct	_	_

1	B	b	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	epithelial	epithelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	conj	_	_
6	have	have	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	pivotal	pivotal	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	life	life	NN	NN	_	13	compound	_	_
13	cycle	cycle	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	virus	virus	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	former	former	JJ	JJ	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	become	become	VB	VB	_	0	root	_	_
5	latently	latently	RB	RB	_	6	advmod	_	_
6	infected	infected	JJ	JJ	_	4	xcomp	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	thought	think	VBN	VBN	_	4	conj	_	_
10	to	to	TO	TO	_	14	mark	_	_
11	be	be	VB	VB	_	14	cop	_	_
12	the	the	DT	DT	_	14	det	_	_
13	virus	virus	NN	NN	_	14	compound	_	_
14	reservoir	reservoir	NN	NN	_	9	xcomp	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vivo	vivo	FW	FW	_	14	advmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	whereas	whereas	IN	IN	_	4	dep	_	_
19	the	the	DT	DT	_	20	det	_	_
20	latter	latter	JJ	JJ	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	4	parataxis	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	cop	_	_
25	permissive	permissive	JJ	JJ	_	22	xcomp	_	_
26	for	for	IN	IN	_	28	case	_	_
27	lytic	lytic	JJ	JJ	_	28	amod	_	_
28	replication	replication	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	replication	replication	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	EBV	ebv	NN	NN	_	3	nmod	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vivo	vivo	FW	FW	_	3	advmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	0	root	_	_
10	primarily	primarily	RB	RB	_	14	advmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	host	host	NN	NN	_	14	compound	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
15	selecting	select	VBG	VBG	_	14	acl	_	_
16	for	for	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	that	that	WDT	WDT	_	21	nsubj	_	_
19	are	be	VBP	VBP	_	21	cop	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	permissive	permissive	JJ	JJ	_	17	acl:relcl	_	_
22	for	for	IN	IN	_	24	case	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	replication	replication	NN	NN	_	21	nmod	_	_
25	as	as	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	result	result	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	particular	particular	JJ	JJ	_	31	amod	_	_
31	set	set	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	factors	factor	NNS	NNS	_	3	nsubj	_	_
3	control	control	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
9	immediate-early	immediate-early	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	,	,	,	,	_	3	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	addition	addition	NN	NN	_	23	nmod	_	_
15	,	,	,	,	_	23	punct	_	_
16	lytic	lytic	JJ	JJ	_	21	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	latent	latent	JJ	JJ	_	16	conj	_	_
19	cycle	cycle	NN	NN	_	21	compound	_	_
20	regulatory	regulatory	JJ	JJ	_	21	amod	_	_
21	genes	gene	NNS	NNS	_	23	nsubj	_	_
22	negatively	negatively	RB	RB	_	23	advmod	_	_
23	interfere	interfere	VBP	VBP	_	3	conj	_	_
24	with	with	IN	IN	_	26	case	_	_
25	each	each	DT	DT	_	26	det	_	_
26	other	other	JJ	JJ	_	23	nmod	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	thus	thus	RB	RB	_	23	advmod	_	_
29	link	link	VBP	VBP	_	23	dep	_	_
30	cellular	cellular	JJ	JJ	_	35	amod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	viral	viral	JJ	JJ	_	30	conj	_	_
33	gene	gene	NN	NN	_	35	compound	_	_
34	regulatory	regulatory	JJ	JJ	_	35	amod	_	_
35	mechanisms	mechanism	NNS	NNS	_	29	dobj	_	_
36	.	.	.	.	_	3	punct	_	_

1	Disturbance	disturbance	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	both	both	CC	CC	_	6	dep	_	_
4	the	the	DT	DT	_	6	det	_	_
5	immune	immune	JJ	JJ	_	6	amod	_	_
6	surveillance	surveillance	NN	NN	_	1	nmod	_	_
7	as	as	RB	RB	_	6	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	viral	viral	JJ	JJ	_	12	amod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	regulation	regulation	NN	NN	_	6	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	result	result	VB	VB	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	EBV-associated	ebv-associated	JJ	JJ	_	17	amod	_	_
17	disease	disease	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	5	compound	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	type-1	type-1	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	0	root	_	_
6	:	:	:	:	_	5	punct	_	_
7	role	role	NN	NN	_	5	dep	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	5'-untranslated	5'-untranslated	JJ	JJ	_	12	amod	_	_
11	leader	leader	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	review	review	NN	NN	_	7	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	type-1	type-1	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIV-1	hiv-1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	transcription	transcription	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	interaction	interaction	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	host-cell	host-cell	JJ	JJ	_	17	amod	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	13	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	cis-regulatory	cis-regulatory	JJ	JJ	_	21	amod	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	13	nmod	_	_
22	within	within	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	viral	viral	JJ	JJ	_	27	amod	_	_
25	long	long	JJ	JJ	_	27	amod	_	_
26	terminal	terminal	JJ	JJ	_	27	amod	_	_
27	repeat	repeat	NN	NN	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	LTR	ltr	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	10	punct	_	_

1	Much	much	JJ	JJ	_	2	amod	_	_
2	attention	attention	NN	NN	_	4	nsubj	_	_
3	has	have	VBZ	VBZ	_	4	aux	_	_
4	focused	focus	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	series	series	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	sequence	sequence	NN	NN	_	10	compound	_	_
10	elements	element	NNS	NNS	_	7	nmod	_	_
11	upstream	upstream	JJ	JJ	_	10	advmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
15	initiation	initiation	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	U3	u3	NN	NN	_	20	compound	_	_
20	region	region	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	LTR	ltr	NN	NN	_	20	nmod	_	_
24	including	include	VBG	VBG	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	Sp1	sp1	NN	NN	_	16	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	sites	site	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	6	nsubj	_	_
3	,	,	,	,	_	6	punct	_	_
4	however	however	RB	RB	_	6	advmod	_	_
5	,	,	,	,	_	6	punct	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	12	det	_	_
9	transcribed	transcribe	VBN	VBN	_	12	amod	_	_
10	5'-untranslated	5'-untranslated	JJ	JJ	_	12	amod	_	_
11	leader	leader	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	17	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	5'-UTR	5'-utr	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	contains	contain	VBZ	VBZ	_	6	ccomp	_	_
18	important	important	JJ	JJ	_	20	amod	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	17	dobj	_	_
21	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	regulatory	regulatory	JJ	JJ	_	3	amod	_	_
3	elements	element	NNS	NNS	_	8	nsubj	_	_
4	situated	situated	JJ	JJ	_	3	amod	_	_
5	downstream	downstream	JJ	JJ	_	4	advmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	transcription	transcription	NN	NN	_	5	nmod	_	_
8	interact	interact	VBP	VBP	_	0	root	_	_
9	with	with	IN	IN	_	14	case	_	_
10	constitutive	constitutive	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	inducible	inducible	JJ	JJ	_	10	conj	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	mediate	mediate	VBP	VBP	_	8	conj	_	_
17	transmission	transmission	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	cellular	cellular	JJ	JJ	_	21	amod	_	_
20	activation	activation	NN	NN	_	21	compound	_	_
21	signals	signal	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	8	punct	_	_
23	and	and	CC	CC	_	8	cc	_	_
24	are	be	VBP	VBP	_	25	cop	_	_
25	important	important	JJ	JJ	_	8	conj	_	_
26	for	for	IN	IN	_	28	case	_	_
27	efficient	efficient	JJ	JJ	_	28	amod	_	_
28	HIV-1	hiv-1	NN	NN	_	25	nmod	_	_
29	transcription	transcription	NN	NN	_	28	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	replication	replication	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	5'-UTR	5'-utr	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	AP-1	ap-1	NN	NN	_	9	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	NF-AT	nf-at	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	IRF	irf	NN	NN	_	10	conj	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	Sp1	sp1	NN	NN	_	10	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Mutations	mutation	NNS	NNS	_	7	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	these	these	DT	DT	_	5	det	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	1	nmod	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	interfere	interfere	VB	VB	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	viral	viral	JJ	JJ	_	11	amod	_	_
11	response	response	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	cell	cell	NN	NN	_	15	compound	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	signals	signal	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	decrease	decrease	VB	VB	_	7	conj	_	_
18	LTR	ltr	NN	NN	_	19	compound	_	_
19	transcription	transcription	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	7	punct	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	inhibit	inhibit	VB	VB	_	7	conj	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	replication	replication	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	5'-UTR	5'-utr	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	interacts	interact	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	nucleosome	nucleosome	NN	NN	_	4	nmod	_	_
9	that	that	WDT	WDT	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	displaced	displace	VBN	VBN	_	8	acl:relcl	_	_
13	during	during	IN	IN	_	15	case	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	latent	latent	JJ	JJ	_	19	amod	_	_
19	provirus	provirus	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	9	det	_	_
5	inducible	inducible	JJ	JJ	_	9	amod	_	_
6	transcription	transcription	NN	NN	_	9	compound	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sites	site	NNS	NNS	_	13	nsubj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	5'-UTR	5'-utr	NN	NN	_	9	nmod	_	_
13	comprise	comprise	VBP	VBP	_	2	ccomp	_	_
14	a	a	DT	DT	_	17	det	_	_
15	downstream	downstream	JJ	JJ	_	17	amod	_	_
16	enhancer	enhancer	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	13	dobj	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	function	function	VB	VB	_	17	acl:relcl	_	_
21	independent	independent	JJ	JJ	_	20	dep	_	_
22	of	of	IN	IN	_	21	nmod	_	_
23	,	,	,	,	_	21	punct	_	_
24	or	or	CC	CC	_	21	cc	_	_
25	in	in	IN	IN	_	27	case	_	_
26	concert	concert	NN	NN	_	27	dep	_	_
27	with	with	IN	IN	_	21	conj	_	_
28	,	,	,	,	_	21	punct	_	_
29	the	the	DT	DT	_	31	det	_	_
30	LTR	ltr	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	21	dep	_	_
32	to	to	TO	TO	_	34	mark	_	_
33	rapidly	rapidly	RB	RB	_	34	advmod	_	_
34	increase	increase	VB	VB	_	20	xcomp	_	_
35	latent	latent	JJ	JJ	_	37	amod	_	_
36	proviral	proviral	JJ	JJ	_	37	amod	_	_
37	transcription	transcription	NN	NN	_	34	dobj	_	_
38	in	in	IN	IN	_	43	case	_	_
39	response	response	NN	NN	_	43	dep	_	_
40	to	to	TO	TO	_	43	case	_	_
41	cell	cell	NN	NN	_	43	compound	_	_
42	activation	activation	NN	NN	_	43	compound	_	_
43	signals	signal	NNS	NNS	_	34	nmod	_	_
44	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	describe	describe	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	host-cell	host-cell	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	6	dobj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	interact	interact	VBP	VBP	_	10	acl:relcl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	5'-UTR	5'-utr	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	discuss	discuss	VBP	VBP	_	6	conj	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	role	role	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	regulation	regulation	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	cloning	cloning	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	FKHRL1P2	fkhrl1p2	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	member	member	NN	NN	_	4	appos	_	_
8	of	of	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	developmentally	developmentally	RB	RB	_	11	advmod	_	_
11	regulated	regulate	VBN	VBN	_	17	amod	_	_
12	fork	fork	NN	NN	_	17	compound	_	_
13	head	head	NN	NN	_	17	compound	_	_
14	domain	domain	NN	NN	_	17	compound	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	factor	factor	NN	NN	_	17	compound	_	_
17	family	family	NN	NN	_	7	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	fork	fork	NN	NN	_	11	compound	_	_
9	head	head	NN	NN	_	11	compound	_	_
10	domain	domain	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	5	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	helper	helper	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	5	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	cloned	clone	VBD	VBD	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	characterized	characterize	VBD	VBD	_	2	conj	_	_
5	a	a	DT	DT	_	8	det	_	_
6	fork	fork	NN	NN	_	8	compound	_	_
7	head	head	NN	NN	_	8	compound	_	_
8	cDNA	cdna	NN	NN	_	2	dobj	_	_
9	from	from	IN	IN	_	14	case	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	helper	helper	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	8	nmod	_	_
15	using	use	VBG	VBG	_	2	xcomp	_	_
16	differential	differential	JJ	JJ	_	18	amod	_	_
17	display	display	NN	NN	_	18	compound	_	_
18	RT-PCR	rt-pcr	NN	NN	_	15	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cDNA	cdna	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	11	det	_	_
5	546-nucleotide	546-nucleotide	JJ	JJ	_	11	amod	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	nt	nt	NN	NN	_	11	compound	_	_
8	)	)	-RRB-	-RRB-	_	11	punct	_	_
9	open	open	JJ	JJ	_	11	amod	_	_
10	reading	reading	NN	NN	_	11	compound	_	_
11	frame	frame	NN	NN	_	3	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	ORF	orf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	codes	code	VBZ	VBZ	_	11	acl:relcl	_	_
17	for	for	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	carboxyl-terminal	carboxyl-terminal	JJ	JJ	_	22	amod	_	_
20	180	180	CD	CD	_	22	nummod	_	_
21	amino	amino	NN	NN	_	22	compound	_	_
22	acids	acid	NNS	NNS	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	aa	aa	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	recently	recently	RB	RB	_	29	advmod	_	_
29	identified	identify	VBN	VBN	_	31	amod	_	_
30	fkhrl1	fkhrl1	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	22	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	ORF	orf	NN	NN	_	5	nsubj	_	_
3	does	do	VBZ	VBZ	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	contain	contain	VB	VB	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	characteristic	characteristic	JJ	JJ	_	9	amod	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	domain	domain	NN	NN	_	5	dobj	_	_
10	found	find	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	members	member	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	forkhead	forkhead	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	family	family	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	In-vitro	in-vitro	FW	FW	_	2	compound	_	_
2	transcription/translation	transcription/translation	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	cDNA	cdna	NN	NN	_	2	nmod	_	_
6	expressed	express	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	approximately	approximately	RB	RB	_	11	advmod	_	_
11	20	20	CD	CD	_	12	nummod	_	_
12	kDa	kda	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	antibodies	antibody	NNS	NNS	_	3	dobj	_	_
5	that	that	WDT	WDT	_	7	nsubj	_	_
6	specifically	specifically	RB	RB	_	7	advmod	_	_
7	immunoprecipitated	immunoprecipitate	VBD	VBD	_	4	acl:relcl	_	_
8	the	the	DT	DT	_	11	det	_	_
9	in-vitro-translated	in-vitro-translated	JJ	JJ	_	11	amod	_	_
10	20-kDa	20-kda	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	antibody	antibody	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	recognizes	recognize	VBZ	VBZ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	a	a	DT	DT	_	11	det	_	_
10	70-kDa	70-kda	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	4	dobj	_	_
12	corresponding	correspond	VBG	VBG	_	11	acl	_	_
13	in	in	IN	IN	_	14	case	_	_
14	size	size	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	that	that	DT	DT	_	12	nmod	_	_
17	predicted	predict	VBN	VBN	_	16	acl	_	_
18	for	for	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	fkhrl1	fkhrl1	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	product	product	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	7	nsubj	_	_
4	for	for	IN	IN	_	5	case	_	_
5	fkhrl1	fkhrl1	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	aux	_	_
7	elevated	elevated	JJ	JJ	_	0	root	_	_
8	in	in	IN	IN	_	11	case	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	helper-induced	helper-induced	JJ	JJ	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	comparison	comparison	NN	NN	_	7	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	PHA-stimulated	pha-stimulated	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	characterization	characterization	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	FKHRL1	fkhrl1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
7	related	related	JJ	JJ	_	9	amod	_	_
8	family	family	NN	NN	_	9	compound	_	_
9	members	member	NNS	NNS	_	4	conj	_	_
10	should	should	MD	MD	_	11	aux	_	_
11	shed	shed	VB	VB	_	0	root	_	_
12	light	light	NN	NN	_	11	dobj	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	mechanisms	mechanism	NNS	NNS	_	11	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	this	this	DT	DT	_	22	det	_	_
19	fork	fork	NN	NN	_	22	compound	_	_
20	head	head	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	subfamily	subfamily	NN	NN	_	16	nmod	_	_
23	and	and	CC	CC	_	16	cc	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	role	role	NN	NN	_	16	conj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	helper	helper	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	differentiation	differentiation	NN	NN	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	regulation	regulation	NN	NN	_	30	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	growth	growth	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	11	punct	_	_

1	Isolation	isolation	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	utilization	utilization	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	dendritic	dendritic	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	from	from	IN	IN	_	10	case	_	_
9	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
10	blood	blood	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	assay	assay	VB	VB	_	1	acl	_	_
13	an	a	DT	DT	_	18	det	_	_
14	in	in	FW	FW	_	18	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	primary	primary	JJ	JJ	_	18	amod	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	12	dobj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	varicella-zoster	varicella-zoster	NN	NN	_	22	compound	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	peptides	peptide	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	dendritic	dendritic	JJ	JJ	_	4	amod	_	_
4	cell-based	cell-based	JJ	JJ	_	5	amod	_	_
5	assay	assay	NN	NN	_	20	nsubjpass	_	_
6	used	use	VBN	VBN	_	5	acl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	monitor	monitor	VB	VB	_	6	xcomp	_	_
9	a	a	DT	DT	_	13	det	_	_
10	T	t	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	proliferation	proliferation	NN	NN	_	13	compound	_	_
13	response	response	NN	NN	_	8	dobj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	viral	viral	JJ	JJ	_	16	amod	_	_
16	peptides	peptide	NNS	NNS	_	13	nmod	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	13	advmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	described	describe	VBN	VBN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	Dendritic	dendritic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	autologous	autologous	JJ	JJ	_	7	amod	_	_
5	CD4+	cd4+	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	2	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	isolated	isolate	VBN	VBN	_	0	root	_	_
10	from	from	IN	IN	_	12	case	_	_
11	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
12	blood	blood	NN	NN	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	series	series	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	density-gradient	density-gradient	JJ	JJ	_	18	amod	_	_
18	centrifugations	centrifugation	NNS	NNS	_	15	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	magnetic	magnetic	JJ	JJ	_	22	amod	_	_
21	bead	bead	NN	NN	_	22	compound	_	_
22	separations	separation	NNS	NNS	_	18	conj	_	_
23	(	(	-LRB-	-LRB-	_	18	punct	_	_
24	or	or	CC	CC	_	18	cc	_	_
25	both	both	DT	DT	_	18	conj	_	_
26	)	)	-RRB-	-RRB-	_	18	punct	_	_
27	.	.	.	.	_	9	punct	_	_

1	Peptides	peptide	NNS	NNS	_	20	nsubjpass	_	_
2	corresponding	correspond	VBG	VBG	_	1	acl	_	_
3	to	to	TO	TO	_	4	case	_	_
4	residues	residue	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	immediate	immediate	JJ	JJ	_	9	amod	_	_
8	early	early	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	IE62	ie62	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	of	of	IN	IN	_	15	case	_	_
14	varicella-zoster	varicella-zoster	NN	NN	_	15	compound	_	_
15	virus	virus	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	VZV	vzv	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	used	use	VBN	VBN	_	0	root	_	_
21	as	as	IN	IN	_	23	case	_	_
22	stimulating	stimulate	VBG	VBG	_	23	amod	_	_
23	antigens	antigen	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	20	punct	_	_
25	and	and	CC	CC	_	20	cc	_	_
26	persons	person	NNS	NNS	_	40	nsubj	_	_
27	with	with	IN	IN	_	29	case	_	_
28	no	no	DT	DT	_	29	neg	_	_
29	history	history	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	varicella	varicella	NN	NN	_	29	nmod	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	no	no	DT	DT	_	37	neg	_	_
34	humoral	humoral	JJ	JJ	_	37	amod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	cellular	cellular	JJ	JJ	_	34	conj	_	_
37	immunity	immunity	NN	NN	_	29	conj	_	_
38	to	to	TO	TO	_	39	case	_	_
39	VZV	vzv	NN	NN	_	37	nmod	_	_
40	served	serve	VBD	VBD	_	20	conj	_	_
41	as	as	IN	IN	_	43	case	_	_
42	naive	naive	JJ	JJ	_	43	amod	_	_
43	donors	donor	NNS	NNS	_	40	nmod	_	_
44	for	for	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	assays	assay	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	20	punct	_	_

1	Three	three	CD	CD	_	3	nummod	_	_
2	VZV-susceptible	vzv-susceptible	JJ	JJ	_	3	amod	_	_
3	donors	donor	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	tested	test	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	all	all	DT	DT	_	9	nsubj	_	_
9	demonstrated	demonstrate	VBD	VBD	_	5	conj	_	_
10	an	a	DT	DT	_	13	det	_	_
11	in	in	FW	FW	_	13	amod	_	_
12	vitro	vitro	FW	FW	_	11	dep	_	_
13	response	response	NN	NN	_	9	dobj	_	_
14	to	to	TO	TO	_	17	case	_	_
15	multiple	multiple	JJ	JJ	_	17	amod	_	_
16	VZV	vzv	NN	NN	_	17	compound	_	_
17	peptides	peptide	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	assay	assay	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	potential	potential	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	screen	screen	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	establish	establish	VB	VB	_	4	acl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	immunogenicity	immunogenicity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	viral	viral	JJ	JJ	_	14	amod	_	_
14	antigens	antigen	NNS	NNS	_	11	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	9	advmod	_	_
17	using	use	VBG	VBG	_	9	xcomp	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	17	dobj	_	_
20	from	from	IN	IN	_	22	case	_	_
21	naive	naive	JJ	JJ	_	22	amod	_	_
22	donors	donor	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	modulation	modulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	content	content	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	3-O-methyl-D-glucose	3-o-methyl-d-glucose	NN	NN	_	9	compound	_	_
9	transport	transport	NN	NN	_	2	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	leukocyte	leukocyte	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	obesity	obesity	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	14	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GR	gr	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	3-O-methyl-D	3-o-methyl-d	JJ	JJ	_	8	amod	_	_
8	glucose	glucose	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	3-O-MG	3-o-mg	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	transport	transport	NN	NN	_	2	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	determined	determine	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
17	leukocytes	leukocyte	NNS	NNS	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	MNL	mnl	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	from	from	IN	IN	_	25	case	_	_
22	11	11	CD	CD	_	25	nummod	_	_
23	abdominal	abdominal	JJ	JJ	_	25	amod	_	_
24	obese	obese	JJ	JJ	_	25	amod	_	_
25	subjects	subject	NNS	NNS	_	17	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	10	10	CD	CD	_	31	nummod	_	_
28	pituitary-dependent	pituitary-dependent	JJ	JJ	_	31	amod	_	_
29	Cushing	cushing	NN	NN	_	31	nmod:poss	_	_
30	's	's	POS	POS	_	29	case	_	_
31	syndrome	syndrome	NN	NN	_	25	conj	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	Cushing	cushing	NN	NN	_	35	nmod:poss	_	_
34	's	's	POS	POS	_	33	case	_	_
35	disease	disease	NN	NN	_	31	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	and	and	CC	CC	_	25	cc	_	_
38	10	10	CD	CD	_	40	nummod	_	_
39	healthy	healthy	JJ	JJ	_	40	amod	_	_
40	controls	control	NNS	NNS	_	25	conj	_	_
41	.	.	.	.	_	14	punct	_	_

1	Using	use	VBG	VBG	_	18	advcl	_	_
2	a	a	DT	DT	_	6	det	_	_
3	whole-cell	whole-cell	JJ	JJ	_	6	amod	_	_
4	competitive	competitive	JJ	JJ	_	6	amod	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	assay	assay	NN	NN	_	1	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	3H-dexamethasone	3h-dexamethasone	NN	NN	_	6	conj	_	_
9	as	as	IN	IN	_	10	case	_	_
10	tracer	tracer	NN	NN	_	1	nmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	MNL	mnl	NNS	NNS	_	18	nsubjpass	_	_
13	of	of	IN	IN	_	16	case	_	_
14	abdominal	abdominal	JJ	JJ	_	16	amod	_	_
15	obese	obese	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	12	nmod	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	have	have	VB	VB	_	18	xcomp	_	_
21	4855	4855	CD	CD	_	24	nummod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	1389	1389	CD	CD	_	21	conj	_	_
24	sites/cell	sites/cell	NNS	NNS	_	20	dobj	_	_
25	which	which	WDT	WDT	_	28	nsubj	_	_
26	was	be	VBD	VBD	_	28	cop	_	_
27	significantly	significantly	RB	RB	_	28	advmod	_	_
28	lower	lower	JJR	JJR	_	24	acl:relcl	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	p	p	NN	NN	_	31	dep	_	_
31	&lt;	&lt;	JJR	JJR	_	28	dep	_	_
32	0.05	0.05	CD	CD	_	31	nummod	_	_
33	)	)	-RRB-	-RRB-	_	31	punct	_	_
34	than	than	IN	IN	_	35	case	_	_
35	controls	control	NNS	NNS	_	28	nmod	_	_
36	(	(	-LRB-	-LRB-	_	40	punct	_	_
37	6234	6234	CD	CD	_	40	nummod	_	_
38	+/-	+/-	CC	CC	_	37	cc	_	_
39	1568	1568	CD	CD	_	37	conj	_	_
40	sites/cell	sites/cell	NNS	NNS	_	35	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	20	punct	_	_
43	although	although	IN	IN	_	48	mark	_	_
44	no	no	DT	DT	_	46	neg	_	_
45	significant	significant	JJ	JJ	_	46	amod	_	_
46	difference	difference	NN	NN	_	48	nsubjpass	_	_
47	was	be	VBD	VBD	_	48	auxpass	_	_
48	found	find	VBN	VBN	_	20	advcl	_	_
49	in	in	IN	IN	_	54	case	_	_
50	the	the	DT	DT	_	54	det	_	_
51	mean	mean	JJ	JJ	_	54	amod	_	_
52	serum	serum	NN	NN	_	54	compound	_	_
53	cortisol	cortisol	NN	NN	_	54	compound	_	_
54	level	level	NN	NN	_	48	nmod	_	_
55	.	.	.	.	_	18	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	mean	mean	JJ	JJ	_	3	amod	_	_
3	Kd	kd	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	affinity	affinity	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	was	be	VBD	VBD	_	10	cop	_	_
8	also	also	RB	RB	_	10	advmod	_	_
9	significantly	significantly	RB	RB	_	10	advmod	_	_
10	lower	lower	JJR	JJR	_	0	root	_	_
11	than	than	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	found	find	VBN	VBN	_	12	acl	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	healthy	healthy	JJ	JJ	_	17	amod	_	_
17	controls	control	NNS	NNS	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	25	punct	_	_
19	obese	obese	JJ	JJ	_	20	amod	_	_
20	Kd	kd	NN	NN	_	25	dep	_	_
21	:	:	:	:	_	25	punct	_	_
22	2.92	2.92	CD	CD	_	25	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	0.84	0.84	CD	CD	_	22	conj	_	_
25	nmol/l	nmol/l	NN	NN	_	10	parataxis	_	_
26	,	,	,	,	_	25	punct	_	_
27	control	control	JJ	JJ	_	28	amod	_	_
28	Kd	kd	NN	NN	_	33	dep	_	_
29	:	:	:	:	_	33	punct	_	_
30	4.55	4.55	CD	CD	_	33	nummod	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	0.67	0.67	CD	CD	_	30	conj	_	_
33	nM	nm	NN	NN	_	25	parataxis	_	_
34	,	,	,	,	_	25	punct	_	_
35	p	p	NN	NN	_	36	dep	_	_
36	&lt;	&lt;	JJR	JJR	_	25	parataxis	_	_
37	0.05	0.05	CD	CD	_	36	nummod	_	_
38	)	)	-RRB-	-RRB-	_	25	punct	_	_
39	.	.	.	.	_	10	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	18	nmod	_	_
5	,	,	,	,	_	18	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	characteristics	characteristic	NNS	NNS	_	18	nsubj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	Cushing	cushing	NN	NN	_	13	nmod:poss	_	_
11	's	's	POS	POS	_	10	case	_	_
12	disease	disease	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	8	nmod	_	_
14	were	be	VBD	VBD	_	18	cop	_	_
15	within	within	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	range	range	NN	NN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	At	at	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	same	same	JJ	JJ	_	4	amod	_	_
4	time	time	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	3-O-MG	3-o-mg	NN	NN	_	7	compound	_	_
7	transport	transport	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	determined	determine	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	same	same	JJ	JJ	_	13	amod	_	_
13	subjects	subject	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	Cushing	cushing	NN	NN	_	4	nmod:poss	_	_
3	's	's	POS	POS	_	2	case	_	_
4	disease	disease	NN	NN	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	3-O-MG	3-o-mg	NN	NN	_	7	compound	_	_
7	transport	transport	NN	NN	_	12	nsubj	_	_
8	was	be	VBD	VBD	_	12	cop	_	_
9	within	within	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	range	range	NN	NN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	whereas	whereas	IN	IN	_	12	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	abdominal	abdominal	JJ	JJ	_	17	amod	_	_
17	obesity	obesity	NN	NN	_	22	nmod	_	_
18	this	this	DT	DT	_	19	det	_	_
19	value	value	NN	NN	_	22	nsubj	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	lower	lower	JJR	JJR	_	12	parataxis	_	_
23	than	than	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	healthy	healthy	JJ	JJ	_	26	amod	_	_
26	controls	control	NNS	NNS	_	22	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	abdominal	abdominal	JJ	JJ	_	29	amod	_	_
29	obese	obese	JJ	JJ	_	22	dep	_	_
30	:	:	:	:	_	29	punct	_	_
31	31.90	31.90	CD	CD	_	29	dep	_	_
32	+/-	+/-	CC	CC	_	31	cc	_	_
33	8.20	8.20	CD	CD	_	31	conj	_	_
34	;	;	:	:	_	29	punct	_	_
35	control	control	NN	NN	_	29	dep	_	_
36	:	:	:	:	_	35	punct	_	_
37	46.26	46.26	CD	CD	_	43	nummod	_	_
38	+/-	+/-	CC	CC	_	37	cc	_	_
39	12.91	12.91	CD	CD	_	37	conj	_	_
40	fmol/10(6)	fmol/10(6)	NN	NN	_	43	compound	_	_
41	cell	cell	NN	NN	_	43	compound	_	_
42	,	,	,	,	_	43	punct	_	_
43	min	min	NN	NN	_	35	dep	_	_
44	,	,	,	,	_	29	punct	_	_
45	p	p	NN	NN	_	46	dep	_	_
46	&lt;	&lt;	JJR	JJR	_	29	dep	_	_
47	0.05	0.05	CD	CD	_	46	nummod	_	_
48	)	)	-RRB-	-RRB-	_	29	punct	_	_
49	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	positive	positive	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	3	dobj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	3-O-MG	3-o-mg	JJ	JJ	_	9	amod	_	_
9	transport	transport	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	GR	gr	NNS	NNS	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	capacity	capacity	NN	NN	_	9	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	abdominal	abdominal	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	6	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	r	r	NN	NN	_	19	nsubj	_	_
19	=	=	JJ	JJ	_	3	parataxis	_	_
20	0.89	0.89	CD	CD	_	19	dobj	_	_
21	,	,	,	,	_	19	punct	_	_
22	p	p	NN	NN	_	23	dep	_	_
23	&lt;	&lt;	JJR	JJR	_	19	parataxis	_	_
24	0.001	0.001	CD	CD	_	23	nummod	_	_
25	)	)	-RRB-	-RRB-	_	19	punct	_	_
26	,	,	,	,	_	3	punct	_	_
27	however	however	RB	RB	_	3	advmod	_	_
28	we	we	PRP	PRP	_	31	nsubj	_	_
29	did	do	VBD	VBD	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	find	find	VB	VB	_	3	parataxis	_	_
32	such	such	JJ	JJ	_	34	amod	_	_
33	a	a	DT	DT	_	34	det	_	_
34	correlation	correlation	NN	NN	_	31	dobj	_	_
35	in	in	IN	IN	_	38	case	_	_
36	Cushing	cushing	NN	NN	_	38	nmod:poss	_	_
37	's	's	POS	POS	_	36	case	_	_
38	disease	disease	NN	NN	_	34	nmod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	r	r	NN	NN	_	41	nsubj	_	_
41	=	=	JJ	JJ	_	31	parataxis	_	_
42	0.60	0.60	CD	CD	_	41	dobj	_	_
43	,	,	,	,	_	41	punct	_	_
44	p	p	NN	NN	_	45	dep	_	_
45	&gt;	&gt;	JJR	JJR	_	41	parataxis	_	_
46	0.05	0.05	CD	CD	_	45	nummod	_	_
47	)	)	-RRB-	-RRB-	_	41	punct	_	_
48	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	,	,	,	,	_	17	punct	_	_
6	in	in	IN	IN	_	8	case	_	_
7	abdominal	abdominal	JJ	JJ	_	8	amod	_	_
8	obesity	obesity	NN	NN	_	17	nmod	_	_
9	,	,	,	,	_	17	punct	_	_
10	the	the	DT	DT	_	13	det	_	_
11	GR	gr	NNS	NNS	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	capacity	capacity	NN	NN	_	17	nsubjpass	_	_
14	in	in	IN	IN	_	15	case	_	_
15	MNL	mnl	NNS	NNS	_	13	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	influenced	influence	VBN	VBN	_	3	ccomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	changes	change	NNS	NNS	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	glucose	glucose	NN	NN	_	23	compound	_	_
23	transport	transport	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Down-regulation	down-regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	granzyme	granzyme	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	binding	bind	VBG	VBG	_	2	dobj	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	Ikaros	ikaros	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1	ap-1	NN	NN	_	10	compound	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	6	conj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	granzyme	granzyme	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	6	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	serine	serine	NN	NN	_	5	compound	_	_
3	protease	protease	NN	NN	_	5	compound	_	_
4	granzyme	granzyme	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	an	a	DT	DT	_	9	det	_	_
8	essential	essential	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	granule	granule	NN	NN	_	14	compound	_	_
13	exocytosis	exocytosis	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	a	a	DT	DT	_	19	det	_	_
17	major	major	JJ	JJ	_	19	amod	_	_
18	apoptotic	apoptotic	JJ	JJ	_	19	amod	_	_
19	mechanism	mechanism	NN	NN	_	14	appos	_	_
20	used	use	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	cytotoxic	cytotoxic	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	natural	natural	JJ	JJ	_	28	amod	_	_
27	killer	killer	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	conj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	induce	induce	VB	VB	_	20	xcomp	_	_
31	target	target	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	apoptosis	apoptosis	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	9	punct	_	_

1	Granzyme	granzyme	NN	NN	_	4	compound	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	transcription	transcription	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	activated	activate	VBN	VBN	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
10	upon	upon	IN	IN	_	12	case	_	_
11	antigenic	antigenic	JJ	JJ	_	12	amod	_	_
12	stimulation	stimulation	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	several	several	JJ	JJ	_	17	amod	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	regions	region	NNS	NNS	_	29	nsubjpass	_	_
18	including	include	VBG	VBG	_	21	case	_	_
19	CBF	cbf	NN	NN	_	21	compound	_	_
20	,	,	,	,	_	21	punct	_	_
21	AP-1	ap-1	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	Ikaros	ikaros	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	21	conj	_	_
27	have	have	VBP	VBP	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	shown	show	VBN	VBN	_	6	conj	_	_
30	to	to	TO	TO	_	32	mark	_	_
31	be	be	VB	VB	_	32	cop	_	_
32	essential	essential	JJ	JJ	_	29	xcomp	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	control	control	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	40	case	_	_
37	granzyme	granzyme	NN	NN	_	40	compound	_	_
38	B	b	NN	NN	_	40	compound	_	_
39	promoter	promoter	NN	NN	_	40	compound	_	_
40	activation	activation	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	16	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	1	appos	_	_
5	that	that	WDT	WDT	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	widely	widely	RB	RB	_	8	advmod	_	_
8	used	use	VBN	VBN	_	4	acl:relcl	_	_
9	as	as	IN	IN	_	14	case	_	_
10	an	a	DT	DT	_	14	det	_	_
11	immunomodulatory	immunomodulatory	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	anti-inflammatory	anti-inflammatory	JJ	JJ	_	11	conj	_	_
14	agent	agent	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	1	punct	_	_
16	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
17	granzyme	granzyme	NN	NN	_	20	compound	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	mRNA	mrna	NN	NN	_	20	compound	_	_
20	transcript	transcript	NN	NN	_	16	dobj	_	_
21	in	in	IN	IN	_	26	case	_	_
22	phytohemagglutinin-activated	phytohemagglutinin-activated	JJ	JJ	_	26	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	20	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Transfection	transfection	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	reporter	reporter	NN	NN	_	5	compound	_	_
5	construct	construct	NN	NN	_	1	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	11	det	_	_
8	-148	-148	CD	CD	_	11	nummod	_	_
9	to	to	TO	TO	_	11	dep	_	_
10	+60	+60	CD	CD	_	11	nummod	_	_
11	region	region	NN	NN	_	6	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	granzyme	granzyme	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	11	nmod	_	_
18	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	this	this	DT	DT	_	21	det	_	_
21	region	region	NN	NN	_	24	nsubj	_	_
22	was	be	VBD	VBD	_	24	cop	_	_
23	the	the	DT	DT	_	24	det	_	_
24	target	target	NN	NN	_	18	ccomp	_	_
25	for	for	IN	IN	_	27	case	_	_
26	dexamethasone	dexamethasone	NN	NN	_	27	compound	_	_
27	repression	repression	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	Mutation	mutation	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	Ikaros	ikaros	NN	NN	_	7	compound	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	AP-1	ap-1	NN	NN	_	3	conj	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	sites	site	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	15	case	_	_
9	the	the	DT	DT	_	15	dep	_	_
10	context	context	NN	NN	_	15	dep	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	granzyme	granzyme	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	1	nmod	_	_
16	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	both	both	DT	DT	_	19	det	_	_
19	sites	site	NNS	NNS	_	20	nsubj	_	_
20	participate	participate	VBP	VBP	_	16	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	dexamethasone-mediated	dexamethasone-mediated	JJ	JJ	_	23	amod	_	_
23	inhibition	inhibition	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	granzyme	granzyme	NN	NN	_	29	compound	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	promoter	promoter	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	16	punct	_	_

1	Electromobility	electromobility	NN	NN	_	3	compound	_	_
2	shift	shift	NN	NN	_	3	compound	_	_
3	assay	assay	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	dexamethasone	dexamethasone	NN	NN	_	7	nsubj	_	_
7	abolished	abolish	VBD	VBD	_	4	ccomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	nmod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Ikaros	ikaros	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	9	nmod	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	reduced	reduce	VBD	VBD	_	7	conj	_	_
21	AP-1	ap-1	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	dexamethasone	dexamethasone	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	able	able	JJ	JJ	_	3	ccomp	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	abrogate	abrogate	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	human	human	JJ	JJ	_	19	amod	_	_
16	granzyme	granzyme	NN	NN	_	19	compound	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	12	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	inhibiting	inhibit	VBG	VBG	_	9	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	binding	binding	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	at	at	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	AP-1	ap-1	NN	NN	_	32	compound	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Ikaros	ikaros	NN	NN	_	29	conj	_	_
32	sites	site	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	delta-globin	delta-globin	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	primary	primary	JJ	JJ	_	12	amod	_	_
10	adult	adult	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	1	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Restoration	restoration	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CCAAT	ccaat	NN	NN	_	5	compound	_	_
5	box	box	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	1	cc	_	_
7	insertion	insertion	NN	NN	_	1	conj	_	_
8	of	of	IN	IN	_	17	case	_	_
9	an	a	DT	DT	_	17	det	_	_
10	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
11	Kruppel-like	kruppel-like	JJ	JJ	_	17	amod	_	_
12	factor	factor	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	EKLF	eklf	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	7	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	delta	delta	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	1	nmod	_	_
22	activates	activate	VBZ	VBZ	_	0	root	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	29	case	_	_
26	several	several	JJ	JJ	_	29	amod	_	_
27	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	extended	extend	VBD	VBD	_	0	root	_	_
3	these	these	DT	DT	_	4	det	_	_
4	studies	study	NNS	NNS	_	2	dobj	_	_
5	using	use	VBG	VBG	_	2	xcomp	_	_
6	a	a	DT	DT	_	16	det	_	_
7	novel	novel	JJ	JJ	_	16	amod	_	_
8	primary	primary	JJ	JJ	_	16	amod	_	_
9	human	human	JJ	JJ	_	16	amod	_	_
10	adult	adult	JJ	JJ	_	16	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
12	cell	cell	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	hAEC	haec	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	system	system	NN	NN	_	5	dobj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	investigate	investigate	VB	VB	_	2	advcl	_	_
19	these	these	DT	DT	_	20	det	_	_
20	effects	effect	NNS	NNS	_	18	dobj	_	_
21	at	at	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	late	late	JJ	JJ	_	25	amod	_	_
24	erythroblast	erythroblast	NN	NN	_	25	compound	_	_
25	stage	stage	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Restoration	restoration	NN	NN	_	27	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	CCAAT	ccaat	NN	NN	_	5	compound	_	_
5	box	box	NN	NN	_	1	nmod	_	_
6	at	at	IN	IN	_	8	case	_	_
7	-70	-70	CD	CD	_	8	nummod	_	_
8	bp	bp	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	or	or	CC	CC	_	1	cc	_	_
11	insertion	insertion	NN	NN	_	1	conj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	EKLF	eklf	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	-85	-85	CD	CD	_	19	nummod	_	_
19	bp	bp	NN	NN	_	11	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	-95	-95	CD	CD	_	22	nummod	_	_
22	bp	bp	NN	NN	_	19	conj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	promoter	promoter	NN	NN	_	1	nmod	_	_
26	significantly	significantly	RB	RB	_	27	advmod	_	_
27	increased	increase	VBD	VBD	_	0	root	_	_
28	delta	delta	NN	NN	_	31	compound	_	_
29	globin	globin	NN	NN	_	31	compound	_	_
30	gene	gene	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	27	dobj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	hAEC	haec	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	27	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	altered	altered	JJ	JJ	_	8	amod	_	_
7	CCAAT	ccaat	NN	NN	_	8	compound	_	_
8	box	box	NN	NN	_	22	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CCAAC	ccaac	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	lack	lack	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	EKLF	eklf	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	delta-globin	delta-globin	NN	NN	_	8	nmod	_	_
22	contribute	contribute	VBP	VBP	_	3	ccomp	_	_
23	to	to	TO	TO	_	26	case	_	_
24	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
25	low	low	JJ	JJ	_	26	amod	_	_
26	level	level	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	expression	expression	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	hAEC	haec	NN	NN	_	32	compound	_	_
32	model	model	NN	NN	_	28	nmod	_	_
33	as	as	RB	RB	_	22	advmod	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	B29	b29	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	7	compound	_	_
5	beta-chain	beta-chain	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	gene	gene	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	genetic	genetic	JJ	JJ	_	11	amod	_	_
11	target	target	NN	NN	_	0	root	_	_
12	for	for	IN	IN	_	15	case	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	B-cell	b-cell	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	Early	early	JJ	JJ	_	3	amod	_	_
2	B-cell	b-cell	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	10	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBF	ebf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	0	root	_	_
11	suggested	suggest	VBN	VBN	_	10	acl	_	_
12	as	as	IN	IN	_	13	case	_	_
13	essential	essential	JJ	JJ	_	11	advcl	_	_
14	for	for	IN	IN	_	17	case	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	B-lymphocyte	b-lymphocyte	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	13	nmod	_	_
18	by	by	IN	IN	_	19	case	_	_
19	findings	finding	NNS	NNS	_	11	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	mice	mouse	NNS	NNS	_	19	nmod	_	_
22	where	where	WRB	WRB	_	28	advmod	_	_
23	the	the	DT	DT	_	25	det	_	_
24	coding	code	VBG	VBG	_	25	amod	_	_
25	gene	gene	NN	NN	_	28	nsubjpass	_	_
26	has	have	VBZ	VBZ	_	28	aux	_	_
27	been	be	VBN	VBN	_	28	auxpass	_	_
28	inactivated	inactivate	VBN	VBN	_	21	acl:relcl	_	_
29	by	by	IN	IN	_	31	case	_	_
30	homologous	homologous	JJ	JJ	_	31	amod	_	_
31	disruption	disruption	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	makes	make	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	identification	identification	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	genetic	genetic	JJ	JJ	_	7	amod	_	_
7	targets	target	NNS	NNS	_	4	nmod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	this	this	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	pertinent	pertinent	JJ	JJ	_	2	xcomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	understanding	understanding	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	early	early	JJ	JJ	_	19	amod	_	_
18	B-cell	b-cell	NN	NN	_	19	compound	_	_
19	development	development	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	lack	lack	NN	NN	_	24	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	B29	b29	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	coding	code	VBG	VBG	_	5	acl	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	beta	beta	NN	NN	_	11	compound	_	_
11	subunit	subunit	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	B-cell	b-cell	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	complex	complex	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	pro-B	pro-b	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	2	nmod	_	_
21	from	from	IN	IN	_	23	case	_	_
22	EBF-deficient	ebf-deficient	JJ	JJ	_	23	amod	_	_
23	mice	mouse	NNS	NNS	_	20	nmod	_	_
24	suggested	suggest	VBD	VBD	_	0	root	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	B29	b29	NN	NN	_	31	nsubj	_	_
27	might	might	MD	MD	_	31	aux	_	_
28	be	be	VB	VB	_	31	cop	_	_
29	a	a	DT	DT	_	31	det	_	_
30	genetic	genetic	JJ	JJ	_	31	amod	_	_
31	target	target	NN	NN	_	24	ccomp	_	_
32	for	for	IN	IN	_	33	case	_	_
33	EBF	ebf	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	24	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	here	here	RB	RB	_	3	advmod	_	_
3	present	present	VBP	VBP	_	0	root	_	_
4	data	datum	NNS	NNS	_	3	dobj	_	_
5	suggesting	suggest	VBG	VBG	_	4	acl	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	EBF	ebf	NN	NN	_	8	nsubj	_	_
8	interacts	interact	VBZ	VBZ	_	5	ccomp	_	_
9	with	with	IN	IN	_	12	case	_	_
10	three	three	CD	CD	_	12	nummod	_	_
11	independent	independent	JJ	JJ	_	12	amod	_	_
12	sites	site	NNS	NNS	_	8	nmod	_	_
13	within	within	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	mouse	mouse	NN	NN	_	17	compound	_	_
16	B29	b29	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	ectopic	ectopic	JJ	JJ	_	4	amod	_	_
4	expression	expression	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	EBF	ebf	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	HeLa	hela	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	activated	activate	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	B29	b29	NN	NN	_	15	compound	_	_
13	promoter-controlled	promoter-controlled	JJ	JJ	_	15	amod	_	_
14	reporter	reporter	NN	NN	_	15	compound	_	_
15	construct	construct	NN	NN	_	10	dobj	_	_
16	13-fold	13-fold	RB	RB	_	10	advmod	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	induced	induce	VBD	VBD	_	10	conj	_	_
19	a	a	DT	DT	_	21	det	_	_
20	low	low	JJ	JJ	_	21	amod	_	_
21	level	level	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	expression	expression	NN	NN	_	21	nmod	_	_
24	from	from	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	endogenous	endogenous	JJ	JJ	_	28	amod	_	_
27	B29	b29	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	Finally	finally	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	mutations	mutation	NNS	NNS	_	9	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	EBF	ebf	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	3	nmod	_	_
9	diminished	diminish	VBD	VBD	_	0	root	_	_
10	B29	b29	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	pre-B	pre-b	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	while	while	IN	IN	_	22	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	same	same	JJ	JJ	_	19	amod	_	_
19	mutations	mutation	NNS	NNS	_	22	nsubj	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	have	have	VB	VB	_	9	advcl	_	_
23	as	as	IN	IN	_	24	dep	_	_
24	striking	striking	JJ	JJ	_	26	amod	_	_
25	an	a	DT	DT	_	26	det	_	_
26	effect	effect	NN	NN	_	22	dobj	_	_
27	on	on	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	function	function	NN	NN	_	22	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	B-cell	b-cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	22	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	later	later	JJ	JJ	_	37	amod	_	_
36	differentiation	differentiation	NN	NN	_	37	compound	_	_
37	stages	stage	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	B29	b29	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	genetic	genetic	JJ	JJ	_	11	amod	_	_
11	target	target	NN	NN	_	3	ccomp	_	_
12	for	for	IN	IN	_	13	case	_	_
13	EBF	ebf	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	early	early	JJ	JJ	_	17	amod	_	_
16	B-cell	b-cell	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Interactions	interaction	NNS	NNS	_	11	nsubj	_	_
2	between	between	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	transactivator	transactivator	NN	NN	_	1	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CREB	creb	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	6	conj	_	_
11	increase	increase	VBP	VBP	_	0	root	_	_
12	transcription	transcription	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	19	case	_	_
14	major	major	JJ	JJ	_	19	amod	_	_
15	histocompatibility	histocompatibility	NN	NN	_	19	compound	_	_
16	complex	complex	NN	NN	_	19	compound	_	_
17	class	class	NN	NN	_	19	compound	_	_
18	II	ii	CD	CD	_	19	nummod	_	_
19	genes	gene	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Class	class	NN	NN	_	9	compound	_	_
2	II	ii	CD	CD	_	9	nummod	_	_
3	major	major	JJ	JJ	_	9	amod	_	_
4	histocompatibility	histocompatibility	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	class	class	NN	NN	_	9	compound	_	_
7	II	ii	CD	CD	_	9	nummod	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	genes	gene	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	18	case	_	_
13	a	a	DT	DT	_	18	det	_	_
14	B-cell-specific	b-cell-specific	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	gamma	gamma	NN	NN	_	17	nmod:npmod	_	_
17	interferon-inducible	interferon-inducible	JJ	JJ	_	14	conj	_	_
18	fashion	fashion	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	master	master	JJ	JJ	_	3	amod	_	_
3	switch	switch	NN	NN	_	14	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	the	the	DT	DT	_	14	det	_	_
12	class	class	NN	NN	_	14	compound	_	_
13	II	ii	CD	CD	_	14	nummod	_	_
14	transactivator	transactivator	NN	NN	_	0	root	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	CIITA	ciita	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	one	one	CD	CD	_	14	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	functions	function	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CIITA	ciita	NN	NN	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	6	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	recruit	recruit	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	CREB	creb	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	protein	protein	NN	NN	_	16	dobj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	CBP	cbp	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	to	to	TO	TO	_	27	case	_	_
25	class	class	NN	NN	_	27	compound	_	_
26	II	ii	CD	CD	_	27	nummod	_	_
27	promoters	promoter	NNS	NNS	_	16	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Not	not	RB	RB	_	2	neg	_	_
2	only	only	RB	RB	_	3	cc:preconj	_	_
3	functional	functional	JJ	JJ	_	8	amod	_	_
4	but	but	CC	CC	_	3	cc	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	specific	specific	JJ	JJ	_	3	conj	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	interactions	interaction	NNS	NNS	_	14	nsubjpass	_	_
9	between	between	IN	IN	_	10	case	_	_
10	CIITA	ciita	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CBP	cbp	NN	NN	_	10	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Moreover	moreover	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	dominant	dominant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	form	form	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CBP	cbp	NN	NN	_	6	nmod	_	_
9	decreased	decrease	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	class	class	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	promoters	promoter	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	levels	level	NNS	NNS	_	11	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	determinants	determinant	NNS	NNS	_	17	nmod	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	surface	surface	NN	NN	_	11	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	cells	cell	NNS	NNS	_	24	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	inhibition	inhibition	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	9	case	_	_
6	class	class	NN	NN	_	9	compound	_	_
7	II	ii	CD	CD	_	9	nummod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	hormone	hormone	NN	NN	_	4	nmod	_	_
14	could	could	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	attributed	attribute	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	squelching	squelching	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CBP	cbp	NN	NN	_	19	nmod	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	glucocorticoid	glucocorticoid	NN	NN	_	25	compound	_	_
25	receptor	receptor	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	CBP	cbp	NN	NN	_	10	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	histone	histone	NN	NN	_	8	compound	_	_
8	acetyltransferase	acetyltransferase	NN	NN	_	4	appos	_	_
9	,	,	,	,	_	4	punct	_	_
10	plays	play	VBZ	VBZ	_	2	ccomp	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	transcription	transcription	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	class	class	NN	NN	_	20	compound	_	_
19	II	ii	CD	CD	_	20	nummod	_	_
20	genes	gene	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Interdomain	interdomain	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	ZAP-70	zap-70	NN	NN	_	2	nmod	_	_
5	regulates	regulate	VBZ	VBZ	_	0	root	_	_
6	but	but	CC	CC	_	5	cc	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	required	require	VBN	VBN	_	5	conj	_	_
10	for	for	IN	IN	_	9	nmod	_	_
11	ZAP-70	zap-70	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	function	function	NN	NN	_	5	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	protein	protein	NN	NN	_	5	compound	_	_
3	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	ZAP-70	zap-70	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	T-cell	t-cell	NN	NN	_	6	nmod	_	_
12	activation	activation	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	development	development	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	6	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	T-cell	t-cell	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	stimulation	stimulation	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	ZAP-70	zap-70	NN	NN	_	7	nsubj	_	_
7	associates	associate	VBZ	VBZ	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	receptor	receptor	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	phosphorylated	phosphorylate	VBN	VBN	_	7	conj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	tyrosines	tyrosine	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	19	case	_	_
19	Y292	y292	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	Y315	y315	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	Y319	y319	NN	NN	_	19	conj	_	_
25	within	within	IN	IN	_	27	case	_	_
26	interdomain	interdomain	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	13	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	Previously	previously	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	Y292	y292	NN	NN	_	8	nsubj	_	_
7	negatively	negatively	RB	RB	_	8	advmod	_	_
8	regulates	regulate	VBZ	VBZ	_	4	ccomp	_	_
9	ZAP-70	zap-70	NN	NN	_	10	compound	_	_
10	function	function	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	that	that	IN	IN	_	15	mark	_	_
13	Y315	y315	NN	NN	_	15	nsubj	_	_
14	positively	positively	RB	RB	_	15	advmod	_	_
15	regulates	regulate	VBZ	VBZ	_	8	conj	_	_
16	ZAP-70	zap-70	NN	NN	_	17	compound	_	_
17	function	function	NN	NN	_	15	dobj	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	interacting	interact	VBG	VBG	_	15	advcl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	Vav	vav	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	Y319	y319	NN	NN	_	9	nsubj	_	_
7	also	also	RB	RB	_	9	advmod	_	_
8	positively	positively	RB	RB	_	9	advmod	_	_
9	regulate	regulate	VBP	VBP	_	4	ccomp	_	_
10	ZAP-70	zap-70	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Paradoxically	paradoxically	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	removal	removal	NN	NN	_	28	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	interdomain	interdomain	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	6	punct	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	create	create	VB	VB	_	6	acl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	construct	construct	NN	NN	_	9	dobj	_	_
12	designated	designate	VBN	VBN	_	11	acl	_	_
13	Delta	delta	NN	NN	_	12	xcomp	_	_
14	)	)	-RRB-	-RRB-	_	6	punct	_	_
15	,	,	,	,	_	6	punct	_	_
16	containing	contain	VBG	VBG	_	6	acl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	Y292	y292	NN	NN	_	20	compound	_	_
19	,	,	,	,	_	20	punct	_	_
20	Y315	y315	NN	NN	_	16	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	Y319	y319	NN	NN	_	24	compound	_	_
24	sites	site	NNS	NNS	_	20	conj	_	_
25	,	,	,	,	_	6	punct	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	eliminate	eliminate	VB	VB	_	0	root	_	_
29	the	the	DT	DT	_	30	det	_	_
30	ability	ability	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	ZAP-70	zap-70	NN	NN	_	30	nmod	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	induce	induce	VB	VB	_	30	acl	_	_
35	multiple	multiple	JJ	JJ	_	37	amod	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	reporters	reporter	NNS	NNS	_	34	dobj	_	_
38	in	in	IN	IN	_	42	case	_	_
39	Syk-deficient	syk-deficient	JJ	JJ	_	42	amod	_	_
40	DT-40	dt-40	NN	NN	_	42	compound	_	_
41	B	b	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	34	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	ZAP-70/Syk-deficient	zap-70/syk-deficient	JJ	JJ	_	46	amod	_	_
45	Jurkat	jurkat	NN	NN	_	46	compound	_	_
46	cells	cell	NNS	NNS	_	42	conj	_	_
47	.	.	.	.	_	28	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Delta	delta	NN	NN	_	7	nsubj	_	_
6	still	still	RB	RB	_	7	advmod	_	_
7	utilizes	utilize	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	10	det	_	_
9	same	same	JJ	JJ	_	10	amod	_	_
10	pathways	pathway	NNS	NNS	_	7	dobj	_	_
11	as	as	IN	IN	_	13	case	_	_
12	wild-type	wild-type	JJ	JJ	_	13	amod	_	_
13	ZAP-70	zap-70	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	mediate	mediate	VB	VB	_	7	advcl	_	_
16	NF-AT	nf-at	NN	NN	_	17	compound	_	_
17	induction	induction	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	manifested	manifest	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ability	ability	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Delta	delta	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	restore	restore	VB	VB	_	6	acl	_	_
11	induction	induction	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	calcium	calcium	NN	NN	_	14	compound	_	_
14	fluxes	flux	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	mitogen-activated	mitogen-activated	JJ	JJ	_	19	amod	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	11	conj	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	by	by	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	ability	ability	NN	NN	_	6	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	dominant	dominant	JJ	JJ	_	27	amod	_	_
26	negative	negative	JJ	JJ	_	27	amod	_	_
27	Ras	ra	NNS	NNS	_	23	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	FK506	fk506	NN	NN	_	27	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	block	block	VB	VB	_	23	acl	_	_
32	the	the	DT	DT	_	33	det	_	_
33	induction	induction	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	NF-AT	nf-at	NN	NN	_	36	compound	_	_
36	activity	activity	NN	NN	_	33	nmod	_	_
37	mediated	mediate	VBN	VBN	_	36	acl	_	_
38	by	by	IN	IN	_	39	case	_	_
39	Delta	delta	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Biochemically	biochemically	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	stimulated	stimulate	VBN	VBN	_	8	amod	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	18	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Vav	vav	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	Shc	shc	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	ZAP-70	zap-70	NN	NN	_	10	conj	_	_
16	itself	itself	PRP	PRP	_	15	nmod:npmod	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	diminished	diminish	VBN	VBN	_	3	ccomp	_	_
19	,	,	,	,	_	18	punct	_	_
20	whereas	whereas	IN	IN	_	18	dep	_	_
21	that	that	DT	DT	_	25	nsubjpass	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Slp-76	slp-76	NN	NN	_	21	nmod	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	increased	increase	VBN	VBN	_	18	parataxis	_	_
26	in	in	IN	IN	_	27	case	_	_
27	cells	cell	NNS	NNS	_	25	nmod	_	_
28	reconstituted	reconstitute	VBN	VBN	_	27	acl	_	_
29	with	with	IN	IN	_	30	case	_	_
30	Delta	delta	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Deletion	deletion	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	interdomain	interdomain	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	affect	affect	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	ZAP-70	zap-70	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	9	acl	_	_
13	bind	bind	VB	VB	_	12	dobj	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	receptor	receptor	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	in	in	FW	FW	_	5	amod	_	_
3	vitro	vitro	FW	FW	_	2	dep	_	_
4	kinase	kinase	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ZAP-70	zap-70	NN	NN	_	5	nmod	_	_
8	lacking	lack	VBG	VBG	_	7	acl	_	_
9	interdomain	interdomain	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	8	dobj	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	markedly	markedly	RB	RB	_	13	advmod	_	_
13	reduced	reduce	VBN	VBN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	but	but	CC	CC	_	13	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	still	still	RB	RB	_	21	advmod	_	_
21	required	require	VBN	VBN	_	13	conj	_	_
22	for	for	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	protein	protein	NN	NN	_	28	nmod:poss	_	_
25	's	's	POS	POS	_	24	case	_	_
26	in	in	FW	FW	_	28	amod	_	_
27	vivo	vivo	FW	FW	_	26	dep	_	_
28	activity	activity	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	7	advcl	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	concluded	conclude	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	interdomain	interdomain	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	11	nsubj	_	_
11	regulates	regulate	VBZ	VBZ	_	7	ccomp	_	_
12	but	but	CC	CC	_	11	cc	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	required	require	VBN	VBN	_	11	conj	_	_
16	for	for	IN	IN	_	15	nmod	_	_
17	ZAP-70	zap-70	NN	NN	_	19	compound	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	function	function	NN	NN	_	11	dobj	_	_
20	leading	lead	VBG	VBG	_	19	acl	_	_
21	to	to	TO	TO	_	23	case	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	RT-PCR	rt-pcr	NN	NN	_	4	compound	_	_
4	detection	detection	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	9	case	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	9	amod	_	_
7	virus	virus	NN	NN	_	9	compound	_	_
8	immediate-early	immediate-early	JJ	JJ	_	9	amod	_	_
9	transcripts	transcript	NNS	NNS	_	4	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	CD4+	cd4+	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	CD8+	cd8+	JJ	JJ	_	11	conj	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	AIDS-related	aids-related	JJ	JJ	_	10	amod	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus	virus	NN	NN	_	7	nmod:npmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBV	ebv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-associated	-associated	JJ	JJ	_	10	amod	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lymphomas	lymphoma	NNS	NNS	_	12	nsubj	_	_
11	are	be	VBP	VBP	_	12	aux	_	_
12	emerging	emerge	VBG	VBG	_	0	root	_	_
13	as	as	IN	IN	_	19	case	_	_
14	a	a	DT	DT	_	19	det	_	_
15	new	new	JJ	JJ	_	19	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	distinct	distinct	JJ	JJ	_	15	dep	_	_
18	histopathological	histopathological	JJ	JJ	_	19	amod	_	_
19	entity	entity	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pathway	pathway	NN	NN	_	22	nsubjpass	_	_
3	whereby	whereby	WRB	WRB	_	5	advmod	_	_
4	EBV	ebv	NN	NN	_	5	nsubj	_	_
5	infects	infect	VBZ	VBZ	_	2	acl:relcl	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	5	dobj	_	_
8	as	as	RB	RB	_	2	cc	_	_
9	well	well	RB	RB	_	8	mwe	_	_
10	as	as	IN	IN	_	8	mwe	_	_
11	the	the	DT	DT	_	15	det	_	_
12	initial	initial	JJ	JJ	_	15	amod	_	_
13	EBV	ebv	NN	NN	_	15	compound	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	program	program	NN	NN	_	2	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	has	have	VBZ	VBZ	_	22	aux	_	_
20	not	not	RB	RB	_	22	neg	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	established	establish	VBN	VBN	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	shed	shed	VB	VB	_	20	advcl	_	_
5	light	light	NN	NN	_	4	dobj	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	early	early	JJ	JJ	_	9	amod	_	_
9	events	event	NNS	NNS	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	EBV	ebv	NN	NN	_	13	compound	_	_
13	infection	infection	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	20	punct	_	_
18	we	we	PRP	PRP	_	20	nsubj	_	_
19	have	have	VBP	VBP	_	20	aux	_	_
20	used	use	VBN	VBN	_	0	root	_	_
21	in	in	FW	FW	_	28	amod	_	_
22	situ	situ	FW	FW	_	21	dep	_	_
23	reverse	reverse	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	nmod:npmod	_	_
25	based	based	JJ	JJ	_	28	amod	_	_
26	polymerase	polymerase	NN	NN	_	28	compound	_	_
27	chain	chain	NN	NN	_	28	compound	_	_
28	reaction	reaction	NN	NN	_	20	dobj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	RT-PCR	rt-pcr	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	study	study	VB	VB	_	20	advcl	_	_
34	the	the	DT	DT	_	38	det	_	_
35	initial	initial	JJ	JJ	_	38	amod	_	_
36	EBV	ebv	NN	NN	_	38	compound	_	_
37	transcriptional	transcriptional	JJ	JJ	_	38	amod	_	_
38	program	program	NN	NN	_	33	dobj	_	_
39	in	in	IN	IN	_	44	case	_	_
40	homogeneous	homogeneous	JJ	JJ	_	44	amod	_	_
41	CD4+	cd4+	JJ	JJ	_	44	amod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	CD8+	cd8+	JJ	JJ	_	41	conj	_	_
44	lymphocytes	lymphocyte	NNS	NNS	_	38	nmod	_	_
45	.	.	.	.	_	20	punct	_	_

1	Following	follow	VBG	VBG	_	3	case	_	_
2	EBV	ebv	NN	NN	_	3	compound	_	_
3	infection	infection	NN	NN	_	14	nmod	_	_
4	,	,	,	,	_	14	punct	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	antigen	antigen	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EBNA	ebna	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	expression	expression	NN	NN	_	14	nsubjpass	_	_
12	could	could	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	22	case	_	_
16	T	t	NN	NN	_	22	compound	_	_
17	rosetting	rosetting	NN	NN	_	22	compound	_	_
18	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CD8+	cd8+	JJ	JJ	_	18	conj	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Only	only	RB	RB	_	3	advmod	_	_
2	a	a	DT	DT	_	3	det	_	_
3	few	few	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	viral	viral	JJ	JJ	_	8	amod	_	_
7	capsid	capsid	NN	NN	_	8	compound	_	_
8	antigen	antigen	NN	NN	_	5	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VCA	vca	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	.	.	.	.	_	5	punct	_	_

1	EBV	ebv	NN	NN	_	4	compound	_	_
2	immediate-early	immediate-early	JJ	JJ	_	4	amod	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	transcripts	transcript	NNS	NNS	_	26	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	BZLF1	bzlf1	NN	NN	_	4	dep	_	_
7	,	,	,	,	_	6	punct	_	_
8	BRLF1	brlf1	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	BMLF1	bmlf1	NN	NN	_	6	conj	_	_
12	)	)	-RRB-	-RRB-	_	6	punct	_	_
13	encoded	encode	VBN	VBN	_	4	acl	_	_
14	in	in	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	BamHI	bamhi	NN	NN	_	19	compound	_	_
17	Z	z	NN	NN	_	19	compound	_	_
18	,	,	,	,	_	19	punct	_	_
19	R	r	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	M	m	NN	NN	_	23	compound	_	_
23	fragments	fragment	NNS	NNS	_	19	conj	_	_
24	could	could	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	detected	detect	VBN	VBN	_	0	root	_	_
27	by	by	IN	IN	_	30	case	_	_
28	in	in	FW	FW	_	30	amod	_	_
29	situ	situ	FW	FW	_	28	dep	_	_
30	RT-PCR	rt-pcr	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	37	case	_	_
32	the	the	DT	DT	_	37	det	_	_
33	EBV	ebv	NN	NN	_	37	compound	_	_
34	producer	producer	NN	NN	_	37	compound	_	_
35	cell	cell	NN	NN	_	37	compound	_	_
36	line	line	NN	NN	_	37	compound	_	_
37	B95.8	b95.8	NN	NN	_	30	nmod	_	_
38	.	.	.	.	_	26	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	BZLF1	bzlf1	NN	NN	_	15	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	BRLF1	brlf1	NN	NN	_	6	compound	_	_
5	immediate-early	immediate-early	JJ	JJ	_	6	amod	_	_
6	transcripts	transcript	NNS	NNS	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	2	cc	_	_
10	BMLF1	bmlf1	NN	NN	_	11	compound	_	_
11	transcript	transcript	NN	NN	_	2	conj	_	_
12	,	,	,	,	_	2	punct	_	_
13	could	could	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	detected	detect	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	22	case	_	_
17	individual	individual	JJ	JJ	_	22	amod	_	_
18	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	CD8+	cd8+	JJ	JJ	_	18	conj	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	infected	infect	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	25	case	_	_
25	EBV	ebv	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Demonstration	demonstration	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	EBV	ebv	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	transcripts	transcript	NNS	NNS	_	1	nmod	_	_
6	encoding	encode	VBG	VBG	_	5	acl	_	_
7	immediate-early	immediate-early	JJ	JJ	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	transactivators	transactivator	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	EBV-infected	ebv-infected	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	provides	provide	VBZ	VBZ	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	first	first	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	14	dobj	_	_
18	for	for	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	possible	possible	JJ	JJ	_	21	amod	_	_
21	mechanism	mechanism	NN	NN	_	14	nmod	_	_
22	whereby	whereby	IN	IN	_	25	advmod	_	_
23	EBV	ebv	NN	NN	_	25	nsubj	_	_
24	could	could	MD	MD	_	25	aux	_	_
25	contribute	contribute	VB	VB	_	21	dep	_	_
26	to	to	TO	TO	_	29	case	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	proliferation	proliferation	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	EBV-associated	ebv-associated	JJ	JJ	_	34	amod	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	malignancies	malignancy	NNS	NNS	_	29	conj	_	_
35	.	.	.	.	_	14	punct	_	_

1	Enhanced	enhance	VBN	VBN	_	2	amod	_	_
2	differentiation	differentiation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HL-60	hl-60	NN	NN	_	6	compound	_	_
5	leukemia	leukemia	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ciprofibrate	ciprofibrate	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Ciprofibrate	ciprofibrate	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	6	det	_	_
4	hypolipidaemic	hypolipidaemic	JJ	JJ	_	6	amod	_	_
5	peroxisome	peroxisome	NN	NN	_	6	compound	_	_
6	proliferator	proliferator	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	1	punct	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	differentiation	differentiation	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HL-60	hl-60	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	greatly	greatly	RB	RB	_	5	advmod	_	_
5	potentiated	potentiate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	phorbol	phorbol	NN	NN	_	9	compound	_	_
8	12-myristate	12-myristate	NN	NN	_	9	compound	_	_
9	13-acetate	13-acetate	NN	NN	_	5	nmod	_	_
10	at	at	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	concentration	concentration	NN	NN	_	5	nmod	_	_
13	where	where	WRB	WRB	_	20	advmod	_	_
14	neither	neither	CC	CC	_	16	cc:preconj	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	20	nsubj	_	_
17	nor	nor	CC	CC	_	16	cc	_	_
18	ciprofibrate	ciprofibrate	NN	NN	_	16	conj	_	_
19	alone	alone	RB	RB	_	16	advmod	_	_
20	had	have	VBD	VBD	_	12	acl:relcl	_	_
21	any	any	DT	DT	_	22	det	_	_
22	effect	effect	NN	NN	_	20	dobj	_	_
23	on	on	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	occurs	occur	VBZ	VBZ	_	22	advcl	_	_
3	for	for	IN	IN	_	6	case	_	_
4	HL-60	hl-60	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	differentiation	differentiation	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	12	case	_	_
9	high	high	JJ	JJ	_	12	amod	_	_
10	phorbol	phorbol	NN	NN	_	12	compound	_	_
11	ester	ester	NN	NN	_	12	compound	_	_
12	concentration	concentration	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	22	punct	_	_
14	the	the	DT	DT	_	18	det	_	_
15	ciprofibrate-induced	ciprofibrate-induced	JJ	JJ	_	18	amod	_	_
16	phorbol	phorbol	NN	NN	_	17	nmod:npmod	_	_
17	ester-dependent	ester-dependent	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	22	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	HL-60	hl-60	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	proceeded	proceed	VBD	VBD	_	0	root	_	_
23	through	through	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	monocytic/macrophage	monocytic/macrophage	JJ	JJ	_	26	amod	_	_
26	pathway	pathway	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	induced	induce	VBD	VBD	_	22	conj	_	_
29	the	the	DT	DT	_	30	det	_	_
30	phosphorylation	phosphorylation	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	proteins	protein	NNS	NNS	_	30	nmod	_	_
33	with	with	IN	IN	_	36	case	_	_
34	similar	similar	JJ	JJ	_	36	amod	_	_
35	molecular	molecular	JJ	JJ	_	36	amod	_	_
36	weights	weight	NNS	NNS	_	32	nmod	_	_
37	suggesting	suggest	VBG	VBG	_	22	xcomp	_	_
38	that	that	IN	IN	_	46	mark	_	_
39	increased	increase	VBN	VBN	_	43	amod	_	_
40	protein	protein	NN	NN	_	43	compound	_	_
41	kinase	kinase	NN	NN	_	43	compound	_	_
42	C	c	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	46	nsubjpass	_	_
44	may	may	MD	MD	_	46	aux	_	_
45	be	be	VB	VB	_	46	auxpass	_	_
46	involved	involve	VBN	VBN	_	37	ccomp	_	_
47	in	in	IN	IN	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	effect	effect	NN	NN	_	46	nmod	_	_
50	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	peroxisome	peroxisome	NN	NN	_	4	compound	_	_
3	proliferator-activated	proliferator-activated	JJ	JJ	_	4	amod	_	_
4	receptor	receptor	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PPARalpha	pparalpha	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	expressed	express	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	HL-60	hl-60	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	but	but	CC	CC	_	11	cc	_	_
17	no	no	DT	DT	_	18	neg	_	_
18	changes	change	NNS	NNS	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	observed	observe	VBN	VBN	_	11	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	its	its	PRP$	PRP$	_	23	nmod:poss	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	upon	upon	IN	IN	_	27	case	_	_
25	HL-60	hl-60	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	differentiation	differentiation	NN	NN	_	20	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	6	amod	_	_
2	factor	factor	NN	NN	_	6	compound	_	_
3	of	of	IN	IN	_	6	amod	_	_
4	activated	activate	VBN	VBN	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	AP-1	ap-1	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	insufficient	insufficient	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	14	case	_	_
12	IL-2	il-2	NN	NN	_	14	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	10	nmod	_	_
15	:	:	:	:	_	10	punct	_	_
16	requirement	requirement	NN	NN	_	10	dep	_	_
17	for	for	IN	IN	_	19	case	_	_
18	CD28	cd28	NN	NN	_	19	compound	_	_
19	up-regulation	up-regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	RE/AP	re/ap	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	IL-2	il-2	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	7	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	both	both	CC	CC	_	12	dep	_	_
9	TCR	tcr	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	costimulatory	costimulatory	JJ	JJ	_	8	conj	_	_
12	signals	signal	NNS	NNS	_	7	dobj	_	_
13	.	.	.	.	_	7	punct	_	_

1	IL-2	il-2	NN	NN	_	3	compound	_	_
2	promoter	promoter	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	16	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	Jurkat	jurkat	NN	NN	_	7	compound	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	stimulated	stimulate	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	superantigen	superantigen	NN	NN	_	8	nmod	_	_
11	presented	present	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	Raji	raji	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	requires	require	VBZ	VBZ	_	0	root	_	_
17	CD28	cd28	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	rCTLA4Ig	rctla4ig	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	blocks	block	VBZ	VBZ	_	4	acl:relcl	_	_
8	CD28	cd28	NN	NN	_	9	compound	_	_
9	binding	binding	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	ligand	ligand	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cultures	culture	NNS	NNS	_	2	nmod	_	_
17	decreased	decrease	VBD	VBD	_	0	root	_	_
18	IL-2	il-2	NN	NN	_	20	compound	_	_
19	promoter	promoter	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	dobj	_	_
21	by	by	IN	IN	_	24	case	_	_
22	&gt;	&gt;	JJR	JJR	_	23	advmod	_	_
23	80	80	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	Interestingly	interestingly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	CTLA4Ig	ctla4ig	NN	NN	_	7	nsubj	_	_
4	did	do	VBD	VBD	_	7	aux	_	_
5	not	not	RB	RB	_	7	neg	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	inhibit	inhibit	VB	VB	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	either	either	CC	CC	_	16	cc:preconj	_	_
12	NF	nf	NN	NN	_	16	compound	_	_
13	of	of	IN	IN	_	16	amod	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	NFAT	nfat	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	or	or	CC	CC	_	16	cc	_	_
21	AP-1	ap-1	NN	NN	_	22	compound	_	_
22	reporters	reporter	NNS	NNS	_	16	conj	_	_
23	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	activation	activation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NFAT	nfat	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	AP-1	ap-1	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	insufficient	insufficient	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	13	case	_	_
11	IL-2	il-2	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	an	a	DT	DT	_	6	det	_	_
5	RE/AP	re/ap	NN	NN	_	6	compound	_	_
6	reporter	reporter	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	blocked	block	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	CTLA4Ig	ctla4ig	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	&gt;	&gt;	JJR	JJR	_	13	advmod	_	_
13	90	90	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	requirement	requirement	NN	NN	_	11	nsubj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	CD28	cd28	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	IL-2	il-2	NN	NN	_	10	compound	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	4	nmod	_	_
11	appears	appear	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	16	mark	_	_
13	be	be	VB	VB	_	16	cop	_	_
14	due	due	JJ	JJ	_	16	case	_	_
15	to	to	TO	TO	_	14	mwe	_	_
16	RE/AP	re/ap	NN	NN	_	11	xcomp	_	_
17	and	and	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	16	cc	_	_
19	the	the	DT	DT	_	23	det	_	_
20	NFAT	nfat	NN	NN	_	23	compound	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	AP-1	ap-1	NN	NN	_	20	conj	_	_
23	sites	site	NNS	NNS	_	16	conj	_	_
24	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	14	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	RE/AP	re/ap	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	mediated	mediate	VBN	VBN	_	6	ccomp	_	_
15	by	by	IN	IN	_	16	case	_	_
16	NFAT	nfat	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	because	because	IN	IN	_	26	mark	_	_
19	activation	activation	NN	NN	_	26	nsubjpass	_	_
20	of	of	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	NFAT	nfat	NN	NN	_	23	compound	_	_
23	reporter	reporter	NN	NN	_	19	nmod	_	_
24	is	be	VBZ	VBZ	_	26	auxpass	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	affected	affect	VBN	VBN	_	14	advcl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	addition	addition	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	CTLA4Ig	ctla4ig	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	CD27/CD70	cd27/cd70	NN	NN	_	2	compound	_	_
2	interaction	interaction	NN	NN	_	3	nsubj	_	_
3	augments	augment	VBZ	VBZ	_	0	root	_	_
4	IgE	ige	NN	NN	_	5	compound	_	_
5	secretion	secretion	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	promoting	promote	VBG	VBG	_	3	advcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	differentiation	differentiation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	memory	memory	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	into	into	IN	IN	_	16	case	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IgE	ige	NN	NN	_	5	compound	_	_
5	switching	switching	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	several	several	JJ	JJ	_	11	amod	_	_
11	signals	signal	NNS	NNS	_	9	dobj	_	_
12	given	give	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cell	cell	NN	NN	_	17	nmod:npmod	_	_
17	contact-delivered	contact-delivered	JJ	JJ	_	18	amod	_	_
18	signals	signal	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CD27/CD70	cd27/cd70	NN	NN	_	9	compound	_	_
9	interaction	interaction	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	B	b	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	IgE	ige	NN	NN	_	14	compound	_	_
14	synthesis	synthesis	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	CD27	cd27	NN	NN	_	9	compound	_	_
5	ligand	ligand	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	CD70	cd70	NN	NN	_	9	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	transfectants	transfectant	NNS	NNS	_	2	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	cultures	culture	NNS	NNS	_	2	nmod	_	_
14	increased	increase	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	IgE	ige	NN	NN	_	17	compound	_	_
17	synthesis	synthesis	NN	NN	_	14	dobj	_	_
18	synergistically	synergistically	RB	RB	_	23	advmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	dep	_	_
21	presence	presence	NN	NN	_	23	dep	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-4	il-4	NN	NN	_	14	nmod	_	_
24	plus	plus	CC	CC	_	23	cc	_	_
25	anti-CD40	anti-cd40	JJ	JJ	_	26	amod	_	_
26	mAb	mab	NN	NN	_	23	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	anti-CD40	anti-cd40	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CD70	cd70	NN	NN	_	5	compound	_	_
5	transfectants	transfectant	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	dose	dose	NN	NN	_	8	nmod:npmod	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	completely	completely	RB	RB	_	12	advmod	_	_
12	blocked	block	VBN	VBN	_	8	conj	_	_
13	by	by	IN	IN	_	15	case	_	_
14	anti-CD70	anti-cd70	JJ	JJ	_	15	amod	_	_
15	mAb	mab	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	CD27+	cd27+	JJ	JJ	_	3	amod	_	_
2	B	b	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	had	have	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ability	ability	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	produce	produce	VB	VB	_	6	acl	_	_
9	IgE	ige	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	increased	increase	VBN	VBN	_	9	acl:relcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	contact	contact	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	CD70	cd70	NN	NN	_	18	compound	_	_
18	transfectants	transfectant	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	whereas	whereas	IN	IN	_	4	dep	_	_
21	CD27-	cd27-	JJ	JJ	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	26	nsubj	_	_
24	did	do	VBD	VBD	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	produce	produce	VB	VB	_	4	parataxis	_	_
27	IgE	ige	NN	NN	_	26	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	CD27/CD70	cd27/cd70	NN	NN	_	2	compound	_	_
2	interaction	interaction	NN	NN	_	3	nsubj	_	_
3	enhanced	enhance	VBD	VBD	_	0	root	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	dep	_	_
9	presence	presence	NN	NN	_	11	dep	_	_
10	of	of	IN	IN	_	11	case	_	_
11	IL-4	il-4	NN	NN	_	3	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	IL-4	il-4	NN	NN	_	11	conj	_	_
14	plus	plus	CC	CC	_	13	cc	_	_
15	anti-CD40	anti-cd40	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	augmentation	augmentation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	9	case	_	_
8	CD70	cd70	NN	NN	_	9	compound	_	_
9	transfectants	transfectant	NNS	NNS	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	apparent	apparent	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	CD27+	cd27+	JJ	JJ	_	15	amod	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	but	but	CC	CC	_	11	cc	_	_
18	was	be	VBD	VBD	_	19	cop	_	_
19	mild	mild	JJ	JJ	_	11	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	CD27-	cd27-	JJ	JJ	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	helper	helper	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	13	nsubj	_	_
4	for	for	IN	IN	_	6	case	_	_
5	IgE	ige	NN	NN	_	6	compound	_	_
6	synthesis	synthesis	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	CD27/CD70	cd27/cd70	NN	NN	_	10	compound	_	_
10	interaction	interaction	NN	NN	_	3	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	contribute	contribute	VB	VB	_	0	root	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	enhancement	enhancement	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	germline	germline	NN	NN	_	20	compound	_	_
19	epsilon	epsilon	NN	NN	_	20	compound	_	_
20	transcripts	transcript	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Flow	flow	NN	NN	_	2	nmod:npmod	_	_
2	cytometric	cytometric	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	morphological	morphological	JJ	JJ	_	2	conj	_	_
5	analyses	analysis	NNS	NNS	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	addition	addition	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CD70	cd70	NN	NN	_	12	compound	_	_
12	transfectants	transfectant	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	cultures	culture	NNS	NNS	_	9	nmod	_	_
17	remarkably	remarkably	RB	RB	_	18	advmod	_	_
18	promoted	promote	VBD	VBD	_	6	ccomp	_	_
19	differentiation	differentiation	NN	NN	_	18	dobj	_	_
20	into	into	IN	IN	_	22	case	_	_
21	plasma	plasma	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	30	case	_	_
24	the	the	DT	DT	_	30	dep	_	_
25	presence	presence	NN	NN	_	30	dep	_	_
26	of	of	IN	IN	_	30	case	_	_
27	IL-4	il-4	NN	NN	_	30	compound	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	CD40	cd40	NN	NN	_	27	conj	_	_
30	signaling	signaling	NN	NN	_	18	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CD27	cd27	NN	NN	_	4	compound	_	_
4	cross-linking	cross-linking	NN	NN	_	5	nsubj	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	up-regulation	up-regulation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	positive	positive	JJ	JJ	_	14	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
12	domain	domain	NN	NN	_	14	compound	_	_
13	I-binding	i-binding	JJ	JJ	_	14	amod	_	_
14	factor-1	factor-1	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	signaling	signaling	NN	NN	_	14	nsubj	_	_
9	via	via	IN	IN	_	10	case	_	_
10	CD27	cd27	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	induces	induce	VBZ	VBZ	_	6	ccomp	_	_
15	IgE	ige	NN	NN	_	16	compound	_	_
16	synthesis	synthesis	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	14	punct	_	_
18	in	in	IN	IN	_	24	case	_	_
19	cooperation	cooperation	NN	NN	_	24	dep	_	_
20	with	with	IN	IN	_	24	case	_	_
21	IL-4	il-4	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	CD40	cd40	NN	NN	_	21	conj	_	_
24	signaling	signaling	NN	NN	_	14	nmod	_	_
25	,	,	,	,	_	14	punct	_	_
26	by	by	IN	IN	_	27	mark	_	_
27	promoting	promote	VBG	VBG	_	14	advcl	_	_
28	the	the	DT	DT	_	29	det	_	_
29	generation	generation	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	plasma	plasma	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	through	through	IN	IN	_	34	case	_	_
34	up-regulation	up-regulation	NN	NN	_	27	nmod	_	_
35	of	of	IN	IN	_	40	case	_	_
36	positive	positive	JJ	JJ	_	40	amod	_	_
37	regulatory	regulatory	JJ	JJ	_	40	amod	_	_
38	domain	domain	NN	NN	_	40	compound	_	_
39	I-binding	i-binding	JJ	JJ	_	40	amod	_	_
40	factor-1	factor-1	NN	NN	_	34	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Stat4	stat4	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	species-specific	species-specific	JJ	JJ	_	7	amod	_	_
7	regulation	regulation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	Th	th	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	development	development	NN	NN	_	7	nmod	_	_
12	by	by	IN	IN	_	15	case	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	I	i	CD	CD	_	15	nummod	_	_
15	IFNs	ifn	NNS	NNS	_	7	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Type	type	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	3	nummod	_	_
3	IFNs	ifn	NNS	NNS	_	15	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	in	in	IN	IN	_	3	cc	_	_
9	addition	addition	NN	NN	_	8	dep	_	_
10	to	to	TO	TO	_	8	dep	_	_
11	IL-12	il-12	NN	NN	_	3	conj	_	_
12	,	,	,	,	_	3	punct	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	play	play	VB	VB	_	15	xcomp	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	differentiation	differentiation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	32	case	_	_
25	human	human	JJ	JJ	_	32	amod	_	_
26	,	,	,	,	_	25	punct	_	_
27	but	but	CC	CC	_	28	cc	_	_
28	not	not	RB	RB	_	25	cc	_	_
29	mouse	mouse	NN	NN	_	25	conj	_	_
30	,	,	,	,	_	25	punct	_	_
31	Th	th	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	23	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	6	nsubj	_	_
6	act	act	VBP	VBP	_	2	ccomp	_	_
7	directly	directly	RB	RB	_	6	advmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	drive	drive	VB	VB	_	6	xcomp	_	_
14	Th1	th1	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	13	punct	_	_
17	bypassing	bypass	VBG	VBG	_	13	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	need	need	NN	NN	_	17	dobj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	IL-12-induced	il-12-induced	JJ	JJ	_	22	amod	_	_
22	signaling	signaling	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	whereas	whereas	IN	IN	_	6	dep	_	_
25	IFN-alpha	ifn-alpha	NN	NN	_	28	nsubj	_	_
26	can	can	MD	MD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	substitute	substitute	VB	VB	_	6	parataxis	_	_
29	IL-12	il-12	NN	NN	_	28	dobj	_	_
30	for	for	IN	IN	_	33	case	_	_
31	mouse	mouse	NN	NN	_	33	compound	_	_
32	Th1	th1	NN	NN	_	33	compound	_	_
33	development	development	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	8	nsubj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	this	this	DT	DT	_	7	det	_	_
6	species	species	NNS	NNS	_	7	compound	_	_
7	specificity	specificity	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	11	nsubj	_	_
11	activate	activate	VBP	VBP	_	8	ccomp	_	_
12	Stat4	stat4	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	differentiating	differentiate	VBG	VBG	_	11	advcl	_	_
15	human	human	JJ	JJ	_	22	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	15	cc	_	_
19	mouse	mouse	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	Th	th	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	14	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	IL-12	il-12	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	acts	act	VBZ	VBZ	_	2	acl:relcl	_	_
6	only	only	RB	RB	_	9	advmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	Th1	th1	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	13	nsubj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	activate	activate	VB	VB	_	0	root	_	_
14	Stat4	stat4	NN	NN	_	13	dobj	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	only	only	RB	RB	_	19	cc:preconj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	Th1	th1	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	but	but	CC	CC	_	19	cc	_	_
22	also	also	RB	RB	_	25	advmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	Th2	th2	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	19	conj	_	_
26	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	restimulation	restimulation	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	Th2	th2	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	clones	clone	NNS	NNS	_	7	conj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	dep	_	_
12	presence	presence	NN	NN	_	14	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IFN-alpha	ifn-alpha	NN	NN	_	3	nmod	_	_
15	does	do	VBZ	VBZ	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	induce	induce	VB	VB	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	production	production	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	26	mark	_	_
5	activation	activation	NN	NN	_	26	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Stat4	stat4	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	necessary	necessary	JJ	JJ	_	5	acl:relcl	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	differentiation	differentiation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	naive	naive	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	into	into	IN	IN	_	22	case	_	_
20	polarized	polarize	VBN	VBN	_	22	amod	_	_
21	Th1	th1	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	14	nmod	_	_
23	,	,	,	,	_	5	punct	_	_
24	is	be	VBZ	VBZ	_	26	cop	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	induce	induce	VB	VB	_	26	xcomp	_	_
29	phenotype	phenotype	NN	NN	_	30	compound	_	_
30	reversal	reversal	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	Th2	th2	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Phenylarsine	phenylarsine	NN	NN	_	2	compound	_	_
2	oxide	oxide	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	ex	ex	FW	FW	_	7	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	dobj	_	_
8	.	.	.	.	_	3	punct	_	_

1	Phenylarsine	phenylarsine	NN	NN	_	2	compound	_	_
2	oxide	oxide	NN	NN	_	18	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	PAO	pao	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	described	describe	VBN	VBN	_	2	acl:relcl	_	_
10	as	as	IN	IN	_	12	case	_	_
11	an	a	DT	DT	_	12	det	_	_
12	inhibitor	inhibitor	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
15	phosphatase	phosphatase	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
19	H2O2	h2o2	NN	NN	_	20	compound	_	_
20	release	release	NN	NN	_	18	dobj	_	_
21	from	from	IN	IN	_	26	case	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
24	blood	blood	NN	NN	_	26	compound	_	_
25	mononuclear	mononuclear	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	20	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	PBMCs	pbmc	NNS	NNS	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	as	as	IN	IN	_	31	mark	_	_
31	measured	measure	VBN	VBN	_	18	advcl	_	_
32	by	by	IN	IN	_	33	case	_	_
33	electrochemistry	electrochemistry	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	Since	since	IN	IN	_	12	mark	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	10	compound	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV-1	hiv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	replication	replication	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	known	know	VBN	VBN	_	38	advcl	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	favored	favor	VBN	VBN	_	12	xcomp	_	_
16	under	under	IN	IN	_	19	case	_	_
17	oxidative	oxidative	JJ	JJ	_	19	amod	_	_
18	stress	stress	NN	NN	_	19	compound	_	_
19	conditions	condition	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	38	punct	_	_
21	ex	ex	FW	FW	_	23	amod	_	_
22	vivo	vivo	FW	FW	_	21	dep	_	_
23	experiments	experiment	NNS	NNS	_	38	nsubj	_	_
24	using	use	VBG	VBG	_	23	acl	_	_
25	uninfected	uninfected	JJ	JJ	_	26	amod	_	_
26	PBMCs	pbmc	NNS	NNS	_	24	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	primary	primary	JJ	JJ	_	29	amod	_	_
29	monocytes	monocyte	NNS	NNS	_	26	conj	_	_
30	or	or	CC	CC	_	26	cc	_	_
31	a	a	DT	DT	_	37	det	_	_
32	latently	latently	RB	RB	_	33	advmod	_	_
33	infected	infected	JJ	JJ	_	37	amod	_	_
34	promonocytic	promonocytic	JJ	JJ	_	37	amod	_	_
35	U1	u1	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	line	line	NN	NN	_	26	conj	_	_
38	show	show	VBP	VBP	_	0	root	_	_
39	that	that	IN	IN	_	52	mark	_	_
40	HIV-1	hiv-1	NN	NN	_	52	nsubjpass	_	_
41	replication	replication	NN	NN	_	40	dep	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	reactivation	reactivation	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	40	punct	_	_
45	monitored	monitor	VBN	VBN	_	40	acl	_	_
46	by	by	IN	IN	_	49	case	_	_
47	p24	p24	NN	NN	_	49	compound	_	_
48	antigen	antigen	NN	NN	_	49	compound	_	_
49	measurement	measurement	NN	NN	_	45	nmod	_	_
50	,	,	,	,	_	40	punct	_	_
51	are	be	VBP	VBP	_	52	auxpass	_	_
52	inhibited	inhibit	VBN	VBN	_	38	ccomp	_	_
53	by	by	IN	IN	_	54	case	_	_
54	PAO	pao	NN	NN	_	52	nmod	_	_
55	in	in	IN	IN	_	60	case	_	_
56	a	a	DT	DT	_	60	det	_	_
57	time-	time-	NN	NN	_	60	amod	_	_
58	and	and	CC	CC	_	57	cc	_	_
59	concentration-dependent	concentration-dependent	JJ	JJ	_	57	conj	_	_
60	manner	manner	NN	NN	_	52	nmod	_	_
61	.	.	.	.	_	38	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	linked	link	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	inhibition	inhibition	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	8	nmod	_	_
13	when	when	WRB	WRB	_	17	advmod	_	_
14	uninfected	uninfected	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	induced	induce	VBN	VBN	_	5	advcl	_	_
18	by	by	IN	IN	_	23	case	_	_
19	either	either	CC	CC	_	23	cc:preconj	_	_
20	tumor	tumor	NN	NN	_	23	compound	_	_
21	necrosis	necrosis	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	17	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	phorbol	phorbol	NN	NN	_	29	compound	_	_
28	12-myristate	12-myristate	NN	NN	_	29	compound	_	_
29	13-acetate	13-acetate	NN	NN	_	23	dep	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PMA	pma	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	or	or	CC	CC	_	23	cc	_	_
34	lipopolysaccharide	lipopolysaccharide	NN	NN	_	23	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	LPS	lps	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	5	punct	_	_

1	Mechanism	mechanism	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	interleukin-10	interleukin-10	NN	NN	_	4	compound	_	_
4	inhibition	inhibition	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	T-helper	t-helper	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	superantigen	superantigen	NN	NN	_	4	nmod	_	_
11	at	at	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	level	level	NN	NN	_	4	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	cycle	cycle	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	interleukin-10	interleukin-10	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IL-10	il-10	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	entry	entry	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	quiescent	quiescent	JJ	JJ	_	18	amod	_	_
16	CD4(+)	cd4(+)	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	into	into	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	cycle	cycle	NN	NN	_	13	nmod	_	_
23	upon	upon	IN	IN	_	24	case	_	_
24	stimulation	stimulation	NN	NN	_	13	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	superantigen	superantigen	NN	NN	_	24	nmod	_	_
28	staphylococcal	staphylococcal	JJ	JJ	_	30	amod	_	_
29	enterotoxin	enterotoxin	NN	NN	_	30	compound	_	_
30	B	b	NN	NN	_	27	dep	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	SEB	seb	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	arrested	arrest	VBD	VBD	_	0	root	_	_
3	cells	cell	NNS	NNS	_	2	dobj	_	_
4	at	at	IN	IN	_	5	case	_	_
5	G0/G1	g0/g1	NN	NN	_	2	nmod	_	_
6	.	.	.	.	_	2	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	prevented	prevent	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	downregulation	downregulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p27(Kip1)	p27(kip1)	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	an	a	DT	DT	_	11	det	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	7	appos	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	controls	control	VBZ	VBZ	_	11	acl:relcl	_	_
14	progression	progression	NN	NN	_	13	dobj	_	_
15	out	out	IN	IN	_	19	case	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	G0	g0	NN	NN	_	19	compound	_	_
19	phase	phase	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	cycle	cycle	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	IL-10	il-10	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	prevented	prevent	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	upregulation	upregulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	G1	g1	NN	NN	_	9	compound	_	_
9	cyclins	cyclin	NNS	NNS	_	5	nmod	_	_
10	D2	d2	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	D3	d3	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	proteins	protein	NNS	NNS	_	9	appos	_	_
15	necessary	necessary	JJ	JJ	_	14	amod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	entry	entry	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	progression	progression	NN	NN	_	17	conj	_	_
20	through	through	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	G1	g1	NN	NN	_	23	compound	_	_
23	phase	phase	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	cycle	cycle	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Associated	associate	VBN	VBN	_	11	advcl	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	inhibition	inhibition	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	cycle	cycle	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	IL-10	il-10	NN	NN	_	11	nsubj	_	_
11	suppressed	suppress	VBD	VBD	_	0	root	_	_
12	SEB	seb	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	interleukin-2	interleukin-2	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IL-2	il-2	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	11	punct	_	_

1	Addition	addition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	exogenous	exogenous	JJ	JJ	_	4	amod	_	_
4	IL-2	il-2	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	IL-10-treated	il-10-treated	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	reversed	reverse	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	antiproliferative	antiproliferative	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-10	il-10	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	IL-10	il-10	NN	NN	_	4	compound	_	_
4	effects	effect	NNS	NNS	_	16	nsubjpass	_	_
5	on	on	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	early	early	JJ	JJ	_	9	amod	_	_
8	G1	g1	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	4	nmod	_	_
10	p27(Kip1)	p27(kip1)	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cyclin	cyclin	NN	NN	_	13	compound	_	_
13	D2	d2	NN	NN	_	10	conj	_	_
14	were	be	VBD	VBD	_	16	auxpass	_	_
15	similarly	similarly	RB	RB	_	16	advmod	_	_
16	reversed	reverse	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	exogenous	exogenous	JJ	JJ	_	19	amod	_	_
19	IL-2	il-2	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	this	this	DT	DT	_	3	det	_	_
3	reversal	reversal	NN	NN	_	7	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	aux	_	_
7	pronounced	pronounced	JJ	JJ	_	12	advcl	_	_
8	,	,	,	,	_	12	punct	_	_
9	it	it	PRP	PRP	_	12	nsubj	_	_
10	was	be	VBD	VBD	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	complete	complete	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	suggesting	suggest	VBG	VBG	_	12	xcomp	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	IL-10	il-10	NN	NN	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	have	have	VB	VB	_	14	ccomp	_	_
19	some	some	DT	DT	_	20	det	_	_
20	effects	effect	NNS	NNS	_	18	dobj	_	_
21	not	not	RB	RB	_	22	dep	_	_
22	directly	directly	RB	RB	_	23	advmod	_	_
23	related	relate	VBN	VBN	_	20	amod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	suppression	suppression	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	production	production	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	separation	separation	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	IL-10	il-10	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	effect	effect	VB	VB	_	4	ccomp	_	_
9	purified	purify	VBN	VBN	_	12	amod	_	_
10	CD4(+)	cd4(+)	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	dobj	_	_
13	directly	directly	RB	RB	_	8	advmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	providing	provide	VBG	VBG	_	8	advcl	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	15	dobj	_	_
18	for	for	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	IL-10	il-10	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	on	on	IN	IN	_	27	case	_	_
25	CD4(+)	cd4(+)	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	IL-10	il-10	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	expression	expression	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	IL-2	il-2	NN	NN	_	8	compound	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	regulators	regulator	NNS	NNS	_	4	nmod	_	_
9	c-fos	c-fos	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	c-jun	c-jun	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	inhibit	inhibit	VBP	VBP	_	8	acl:relcl	_	_
16	other	other	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	functions	function	NNS	NNS	_	15	dobj	_	_
19	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	IL-10	il-10	NN	NN	_	9	compound	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	quiescent	quiescent	JJ	JJ	_	14	amod	_	_
12	CD4(+)	cd4(+)	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	9	nmod	_	_
15	is	be	VBZ	VBZ	_	18	cop	_	_
16	mainly	mainly	RB	RB	_	18	advmod	_	_
17	by	by	IN	IN	_	18	mark	_	_
18	blocking	block	VBG	VBG	_	3	ccomp	_	_
19	induction	induction	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-2	il-2	NN	NN	_	19	nmod	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	critical	critical	JJ	JJ	_	19	acl:relcl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	downregulation	downregulation	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	p27(Kip1)	p27(kip1)	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	upregulation	upregulation	NN	NN	_	26	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	D	d	NN	NN	_	33	compound	_	_
33	cyclins	cyclin	NNS	NNS	_	30	nmod	_	_
34	in	in	IN	IN	_	35	case	_	_
35	T-cell	t-cell	NN	NN	_	26	nmod	_	_
36	activation	activation	NN	NN	_	35	dep	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	entry	entry	NN	NN	_	36	conj	_	_
39	into	into	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	cycle	cycle	NN	NN	_	35	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Effect	effect	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	environmental	environmental	JJ	JJ	_	4	amod	_	_
4	estrogens	estrogen	NNS	NNS	_	1	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	IL-1beta	il-1beta	NN	NN	_	8	compound	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	macrophage	macrophage	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Environmental	environmental	JJ	JJ	_	2	amod	_	_
2	estrogens	estrogen	NNS	NNS	_	8	nsubj	_	_
3	or	or	CC	CC	_	2	cc	_	_
4	estrogen	estrogen	NN	NN	_	5	compound	_	_
5	disrupters	disrupter	NNS	NNS	_	2	conj	_	_
6	have	have	VBP	VBP	_	8	aux	_	_
7	recently	recently	RB	RB	_	8	advmod	_	_
8	received	receive	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	great	great	JJ	JJ	_	11	amod	_	_
11	deal	deal	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	attention	attention	NN	NN	_	11	nmod	_	_
14	because	because	IN	IN	_	19	case	_	_
15	of	of	IN	IN	_	14	mwe	_	_
16	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
17	potential	potential	JJ	JJ	_	19	amod	_	_
18	health	health	NN	NN	_	19	compound	_	_
19	impact	impact	NN	NN	_	8	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	reproductive	reproductive	JJ	JJ	_	22	amod	_	_
22	tissues	tissue	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Few	few	JJ	JJ	_	6	amod	_	_
2	,	,	,	,	_	4	punct	_	_
3	if	if	IN	IN	_	4	mark	_	_
4	any	any	DT	DT	_	6	dep	_	_
5	,	,	,	,	_	4	punct	_	_
6	studies	study	NNS	NNS	_	9	nsubjpass	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	made	make	VBN	VBN	_	0	root	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	impact	impact	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	compounds	compound	NNS	NNS	_	12	nmod	_	_
16	on	on	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	system	system	NN	NN	_	12	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	sought	seek	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	2	xcomp	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activities	activity	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	various	various	JJ	JJ	_	10	amod	_	_
9	environmental	environmental	JJ	JJ	_	10	amod	_	_
10	estrogens	estrogen	NNS	NNS	_	6	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	modulation	modulation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	interleukin-1beta	interleukin-1beta	NN	NN	_	20	compound	_	_
17	(	(	-LRB-	-LRB-	_	20	punct	_	_
18	IL-1beta	il-1beta	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	gene	gene	NN	NN	_	13	nmod	_	_
21	in	in	IN	IN	_	26	case	_	_
22	a	a	DT	DT	_	26	det	_	_
23	model	model	NN	NN	_	26	compound	_	_
24	monocytic	monocytic	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	6	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	hER+IL-1beta-CAT+	her+il-1beta-cat+	NN	NN	_	26	appos	_	_
29	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	line	line	NN	NN	_	23	nsubj	_	_
4	stably	stably	RB	RB	_	5	advmod	_	_
5	transfected	transfect	VBN	VBN	_	3	acl	_	_
6	with	with	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	estrogen	estrogen	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	an	a	DT	DT	_	16	det	_	_
14	IL-1beta	il-1beta	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	construct	construct	NN	NN	_	10	conj	_	_
17	fused	fuse	VBN	VBN	_	16	acl	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	CAT	cat	NN	NN	_	22	compound	_	_
21	reporter	reporter	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	17	nmod	_	_
23	allows	allow	VBZ	VBZ	_	0	root	_	_
24	us	we	PRP	PRP	_	23	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	monitor	monitor	VB	VB	_	23	xcomp	_	_
27	the	the	DT	DT	_	28	det	_	_
28	effect	effect	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	estrogenic	estrogenic	JJ	JJ	_	31	amod	_	_
31	compounds	compound	NNS	NNS	_	28	nmod	_	_
32	on	on	IN	IN	_	35	case	_	_
33	IL-1beta	il-1beta	NN	NN	_	35	compound	_	_
34	promoter	promoter	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	23	punct	_	_

1	17beta-estradiol	17beta-estradiol	NN	NN	_	3	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	E2	e2	NN	NN	_	6	nsubj	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	markedly	markedly	RB	RB	_	6	advmod	_	_
6	enhanced	enhance	VBD	VBD	_	0	root	_	_
7	lipopolysaccharide-	lipopolysaccharide-	NN	NN	_	11	nmod:npmod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	LPS	lps	NN	NN	_	11	nmod:npmod	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	induced	induced	JJ	JJ	_	15	amod	_	_
12	IL-1beta	il-1beta	NN	NN	_	13	nmod:npmod	_	_
13	promoter-driven	promoter-driven	JJ	JJ	_	15	amod	_	_
14	CAT	cat	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	6	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	manner	manner	NN	NN	_	6	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mycotoxins	mycotoxin	NNS	NNS	_	7	nsubj	_	_
3	alpha-zearalenol	alpha-zearalenol	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	zearalenone	zearalenone	NN	NN	_	3	conj	_	_
6	both	both	DT	DT	_	2	dep	_	_
7	exhibited	exhibit	VBD	VBD	_	0	root	_	_
8	full	full	JJ	JJ	_	10	amod	_	_
9	agonist	agonist	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	but	but	CC	CC	_	7	cc	_	_
13	at	at	IN	IN	_	15	case	_	_
14	lower	lower	JJR	JJR	_	15	amod	_	_
15	potencies	potency	NNS	NNS	_	28	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	with	with	IN	IN	_	19	case	_	_
18	EC50	ec50	NN	NN	_	19	compound	_	_
19	values	value	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	1.8	1.8	CD	CD	_	24	nummod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	54	54	CD	CD	_	21	conj	_	_
24	nM	nm	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	respectively	respectively	RB	RB	_	24	advmod	_	_
27	,	,	,	,	_	15	punct	_	_
28	compared	compare	VBN	VBN	_	7	conj	_	_
29	with	with	IN	IN	_	30	case	_	_
30	E2	e2	NN	NN	_	28	nmod	_	_
31	at	at	IN	IN	_	33	case	_	_
32	0.5	0.5	CD	CD	_	33	nummod	_	_
33	nM	nm	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	genistein	genistein	NN	NN	_	9	nsubj	_	_
5	was	be	VBD	VBD	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	low-potency	low-potency	JJ	JJ	_	9	amod	_	_
9	agonist	agonist	NN	NN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	having	have	VBG	VBG	_	9	advcl	_	_
12	an	a	DT	DT	_	13	det	_	_
13	EC50	ec50	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	1.5	1.5	CD	CD	_	16	nummod	_	_
16	microM	microm	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	20	ccomp	_	_
2	to	to	TO	TO	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	E2	e2	NN	NN	_	5	compound	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	20	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	slope	slope	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	20	nsubj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	alpha-zearalenol	alpha-zearalenol	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	zearalenone	zearalenone	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	genistein	genistein	NN	NN	_	11	conj	_	_
17	were	be	VBD	VBD	_	20	cop	_	_
18	close	close	JJ	JJ	_	20	advmod	_	_
19	to	to	TO	TO	_	20	dep	_	_
20	3.0	3.0	CD	CD	_	0	root	_	_
21	,	,	,	,	_	20	punct	_	_
22	suggesting	suggest	VBG	VBG	_	20	advcl	_	_
23	positive	positive	JJ	JJ	_	24	amod	_	_
24	cooperativity	cooperativity	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	estrogenic	estrogenic	JJ	JJ	_	28	amod	_	_
28	response	response	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mycotoxins	mycotoxin	NNS	NNS	_	2	nmod	_	_
6	appeared	appear	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	6	xcomp	_	_
10	through	through	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	estrogen	estrogen	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	since	since	IN	IN	_	26	mark	_	_
16	both	both	CC	CC	_	18	cc:preconj	_	_
17	the	the	DT	DT	_	18	det	_	_
18	antiestrogens	antiestrogen	NNS	NNS	_	26	nsubj	_	_
19	H1285	h1285	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	ICI	ici	NN	NN	_	19	conj	_	_
22	182	182	CD	CD	_	21	nummod	_	_
23	,	,	,	,	_	21	punct	_	_
24	780	780	CD	CD	_	21	nummod	_	_
25	effectively	effectively	RB	RB	_	26	advmod	_	_
26	inhibited	inhibit	VBD	VBD	_	9	advcl	_	_
27	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
28	agonist	agonist	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	dose-dependent	dose-dependent	JJ	JJ	_	33	amod	_	_
33	manner	manner	NN	NN	_	26	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Representative	representative	JJ	JJ	_	4	amod	_	_
2	environmental	environmental	JJ	JJ	_	4	amod	_	_
3	estrogenic	estrogenic	JJ	JJ	_	4	amod	_	_
4	compounds	compound	NNS	NNS	_	13	nsubjpass	_	_
5	both	both	CC	CC	_	4	nmod	_	_
6	from	from	IN	IN	_	5	case	_	_
7	plant	plant	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	industrial	industrial	JJ	JJ	_	7	conj	_	_
10	sources	source	NNS	NNS	_	5	dep	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	tested	test	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	Unlike	unlike	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	mycoestrogens	mycoestrogen	NNS	NNS	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	none	none	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	compounds	compound	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	16	punct	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	exception	exception	NN	NN	_	16	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	genistein	genistein	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	16	punct	_	_
16	synergized	synergize	VBD	VBD	_	0	root	_	_
17	with	with	IN	IN	_	18	case	_	_
18	LPS	lps	NN	NN	_	16	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	enhance	enhance	VB	VB	_	16	xcomp	_	_
21	IL-1beta	il-1beta	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	tested	test	VBN	VBN	_	12	advcl	_	_
3	for	for	IN	IN	_	5	case	_	_
4	antiestrogenic	antiestrogenic	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	the	the	DT	DT	_	10	det	_	_
8	industrial	industrial	JJ	JJ	_	10	amod	_	_
9	compound	compound	NN	NN	_	10	compound	_	_
10	4-octylphenol	4-octylphenol	NN	NN	_	12	nsubj	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	able	able	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	antagonize	antagonize	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	response	response	NN	NN	_	14	dobj	_	_
17	to	to	TO	TO	_	18	case	_	_
18	E2	e2	NN	NN	_	16	nmod	_	_
19	;	;	:	:	_	12	punct	_	_
20	however	however	RB	RB	_	12	advmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	the	the	DT	DT	_	23	det	_	_
23	response	response	NN	NN	_	26	nsubj	_	_
24	was	be	VBD	VBD	_	26	cop	_	_
25	three	three	CD	CD	_	26	nummod	_	_
26	orders	order	NNS	NNS	_	12	dep	_	_
27	of	of	IN	IN	_	28	case	_	_
28	magnitude	magnitude	NN	NN	_	26	nmod	_	_
29	less	less	RBR	RBR	_	30	advmod	_	_
30	potent	potent	JJ	JJ	_	26	amod	_	_
31	than	than	IN	IN	_	32	case	_	_
32	H	h	NN	NN	_	30	nmod	_	_
33	1285	1285	CD	CD	_	32	nummod	_	_
34	.	.	.	.	_	12	punct	_	_

1	Naringenin	naringenin	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	plant	plant	NN	NN	_	5	compound	_	_
5	flavonoid	flavonoid	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	little	little	JJ	JJ	_	7	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	no	no	DT	DT	_	8	conj	_	_
11	ability	ability	NN	NN	_	8	dep	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	antagonize	antagonize	VB	VB	_	11	acl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	response	response	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	E2	e2	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Overall	overall	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	some	some	DT	DT	_	9	det	_	_
8	environmental	environmental	JJ	JJ	_	9	amod	_	_
9	estrogens	estrogen	NNS	NNS	_	18	nsubj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	display	display	VBP	VBP	_	9	acl:relcl	_	_
12	agonist	agonist	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	reproductive	reproductive	JJ	JJ	_	16	amod	_	_
16	tissue	tissue	NN	NN	_	11	nmod	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	have	have	VBP	VBP	_	5	ccomp	_	_
19	an	a	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	24	case	_	_
22	IL-1	il-1	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	18	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	hemopoietic-derived	hemopoietic-derived	JJ	JJ	_	27	amod	_	_
27	tissue	tissue	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	position	position	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	ZEBRA	zebra	NN	NN	_	7	compound	_	_
6	activation	activation	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	2	nmod	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	influence	influence	VB	VB	_	0	root	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	biological	biological	JJ	JJ	_	13	amod	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	10	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	herpesvirus	herpesvirus	NN	NN	_	0	root	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	latently	latently	RB	RB	_	12	advmod	_	_
12	infects	infect	VBZ	VBZ	_	9	acl:relcl	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	12	dobj	_	_
15	.	.	.	.	_	9	punct	_	_

1	EBV	ebv	NN	NN	_	2	nsubj	_	_
2	encodes	encode	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	unique	unique	JJ	JJ	_	6	amod	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	known	know	VBN	VBN	_	6	acl	_	_
9	as	as	IN	IN	_	10	case	_	_
10	ZEBRA	zebra	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	disrupt	disrupt	VB	VB	_	6	acl:relcl	_	_
15	viral	viral	JJ	JJ	_	16	amod	_	_
16	latency	latency	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	induce	induce	VB	VB	_	14	conj	_	_
22	lytic	lytic	JJ	JJ	_	24	amod	_	_
23	viral	viral	JJ	JJ	_	24	amod	_	_
24	replication	replication	NN	NN	_	21	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	ZEBRA	zebra	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	bind	bind	VB	VB	_	6	xcomp	_	_
9	at	at	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	EBV	ebv	NN	NN	_	12	compound	_	_
12	origin	origin	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	lytic	lytic	JJ	JJ	_	15	amod	_	_
15	replication	replication	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	necessary	necessary	JJ	JJ	_	6	conj	_	_
20	for	for	IN	IN	_	25	mark	_	_
21	viral	viral	JJ	JJ	_	23	amod	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	replication	replication	NN	NN	_	25	nsubj	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	occur	occur	VB	VB	_	19	advcl	_	_
26	.	.	.	.	_	6	punct	_	_

1	Previously	previously	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	heterologous	heterologous	JJ	JJ	_	7	amod	_	_
6	activation	activation	NN	NN	_	7	compound	_	_
7	domains	domain	NNS	NNS	_	10	nsubj	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	fully	fully	RB	RB	_	10	advmod	_	_
10	substitute	substitute	VB	VB	_	3	ccomp	_	_
11	for	for	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	ZEBRA	zebra	NN	NN	_	15	compound	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	extend	extend	VBP	VBP	_	0	root	_	_
4	those	those	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	3	dobj	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	showing	show	VBG	VBG	_	3	advcl	_	_
8	that	that	IN	IN	_	23	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	position	position	NN	NN	_	23	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	ZEBRA	zebra	NN	NN	_	15	compound	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	10	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	a	a	DT	DT	_	20	det	_	_
18	heterologous	heterologous	JJ	JJ	_	20	amod	_	_
19	replacement	replacement	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	15	conj	_	_
21	does	do	VBZ	VBZ	_	23	aux	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	influence	influence	VB	VB	_	7	ccomp	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	ability	ability	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	function	function	VB	VB	_	25	acl	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	disruption	disruption	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	EBV	ebv	NN	NN	_	33	compound	_	_
33	latency	latency	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	8	nmod	_	_
4	three	three	CD	CD	_	6	nummod	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	clones	clone	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	constructed	construct	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	16	nmod	_	_
11	the	the	DT	DT	_	14	det	_	_
12	ZEBRA	zebra	NN	NN	_	14	compound	_	_
13	activation	activation	NN	NN	_	14	compound	_	_
14	region	region	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	repositioned	reposition	VBN	VBN	_	8	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	carboxy	carboxy	NN	NN	_	20	compound	_	_
20	terminus	terminus	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	mutants	mutant	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	demonstrate	demonstrate	VB	VB	_	4	xcomp	_	_
7	that	that	IN	IN	_	28	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	28	nsubjpass	_	_
10	of	of	IN	IN	_	15	case	_	_
11	ZEBRA	zebra	NN	NN	_	15	nmod:poss	_	_
12	's	's	POS	POS	_	11	case	_	_
13	wild	wild	JJ	JJ	_	15	amod	_	_
14	type	type	NN	NN	_	15	compound	_	_
15	domain	domain	NN	NN	_	9	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	function	function	VB	VB	_	9	acl	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	complex	complex	JJ	JJ	_	22	amod	_	_
21	biological	biological	JJ	JJ	_	22	amod	_	_
22	process	process	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	is	be	VBZ	VBZ	_	28	auxpass	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	compromised	compromise	VBN	VBN	_	6	ccomp	_	_
29	by	by	IN	IN	_	30	mark	_	_
30	altering	alter	VBG	VBG	_	28	advcl	_	_
31	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
32	position	position	NN	NN	_	30	dobj	_	_
33	within	within	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	protein	protein	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	2	nsubj	_	_
2	stabilizes	stabilize	VBZ	VBZ	_	0	root	_	_
3	inhibitory	inhibitory	JJ	JJ	_	4	amod	_	_
4	kappaB-alpha	kappab-alpha	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-10	il-10	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	protects	protect	VBZ	VBZ	_	0	root	_	_
6	animals	animal	NNS	NNS	_	5	dobj	_	_
7	from	from	IN	IN	_	9	case	_	_
8	lethal	lethal	JJ	JJ	_	9	amod	_	_
9	endotoxemia	endotoxemia	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	beneficial	beneficial	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	mediated	mediate	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	in	in	IN	IN	_	8	case	_	_
8	part	part	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	by	by	IN	IN	_	11	case	_	_
11	inhibition	inhibition	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	including	include	VBG	VBG	_	20	case	_	_
18	tumor	tumor	NN	NN	_	20	compound	_	_
19	necrosis	necrosis	NN	NN	_	20	compound	_	_
20	factor-alpha	factor-alpha	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	5	punct	_	_

1	Evidence	evidence	NN	NN	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	IL-10	il-10	NN	NN	_	6	nsubj	_	_
5	may	may	MD	MD	_	6	aux	_	_
6	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
7	activation	activation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor-kappaB	factor-kappab	NN	NN	_	11	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	through	through	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	unknown	unknown	JJ	JJ	_	20	amod	_	_
20	mechanism	mechanism	NN	NN	_	6	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	9	nsubj	_	_
3	in	in	IN	IN	_	7	case	_	_
4	response	response	NN	NN	_	7	dep	_	_
5	to	to	TO	TO	_	7	case	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	signals	signal	NNS	NNS	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	dependent	dependent	JJ	JJ	_	0	root	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	degradation	degradation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
14	associated	associate	VBN	VBN	_	16	amod	_	_
15	inhibitory	inhibitory	JJ	JJ	_	16	amod	_	_
16	peptide	peptide	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
19	kappaB-alpha	kappab-alpha	NN	NN	_	16	appos	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	IkappaB-alpha	ikappab-alpha	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	IL-10	il-10	NN	NN	_	5	nsubj	_	_
5	prevents	prevent	VBZ	VBZ	_	2	ccomp	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	monocyte	monocyte	NN	NN	_	9	compound	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	resultant	resultant	JJ	JJ	_	13	amod	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	9	conj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	stabilization	stabilization	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IkappaB-alpha	ikappab-alpha	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IL-10	il-10	NN	NN	_	10	nmod	_	_
13	on	on	IN	IN	_	22	case	_	_
14	lipopolysaccharide	lipopolysaccharide	NN	NN	_	18	nmod:npmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	LPS	lps	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	-induced	-induced	JJ	JJ	_	22	amod	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	monocyte	monocyte	NN	NN	_	22	compound	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	10	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	conj	_	_
26	,	,	,	,	_	22	punct	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	IkappaB-alpha	ikappab-alpha	NN	NN	_	29	compound	_	_
29	degradation	degradation	NN	NN	_	22	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	from	from	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	donors	donor	NNS	NNS	_	3	nmod	_	_
7	.	.	.	.	_	3	punct	_	_

1	Cells	cell	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	stimulated	stimulate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	5	case	_	_
5	endotoxin	endotoxin	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	LPS	lps	NN	NN	_	5	dep	_	_
8	,	,	,	,	_	7	punct	_	_
9	100	100	CD	CD	_	10	nummod	_	_
10	ng/mL	ng/ml	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	7	punct	_	_
12	with	with	IN	IN	_	16	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	without	without	IN	IN	_	12	conj	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	IL-10	il-10	NN	NN	_	5	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	10	10	CD	CD	_	19	nummod	_	_
19	ng/mL	ng/ml	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	3	punct	_	_

1	Following	follow	VBG	VBG	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	measured	measure	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	supernatants	supernatant	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	ELISA	elisa	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	6	ccomp	_	_
15	by	by	IN	IN	_	19	case	_	_
16	electrophoretic	electrophoretic	JJ	JJ	_	19	amod	_	_
17	mobility	mobility	NN	NN	_	19	compound	_	_
18	shift	shift	NN	NN	_	19	compound	_	_
19	assay	assay	NN	NN	_	14	dep	_	_
20	,	,	,	,	_	6	punct	_	_
21	and	and	CC	CC	_	6	cc	_	_
22	IkappaB-alpha	ikappab-alpha	NN	NN	_	23	compound	_	_
23	levels	level	NNS	NNS	_	6	conj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	Western	western	NN	NN	_	26	compound	_	_
26	blot	blot	NN	NN	_	23	dep	_	_
27	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	after	after	IN	IN	_	6	case	_	_
5	LPS	lps	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	12	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	12	nsubj	_	_
12	increased	increase	VBD	VBD	_	2	ccomp	_	_
13	to	to	TO	TO	_	15	case	_	_
14	798+/-67	798+/-67	CD	CD	_	15	nummod	_	_
15	pg/mL	pg/ml	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	p	p	NN	NN	_	18	dep	_	_
18	&lt;	&lt;	JJR	JJR	_	15	dep	_	_
19	.001	.001	CD	CD	_	18	nummod	_	_
20	versus	versus	CC	CC	_	21	case	_	_
21	control	control	NN	NN	_	18	dep	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	.	.	.	.	_	2	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	attenuated	attenuate	VBD	VBD	_	0	root	_	_
3	LPS-stimulated	lps-stimulated	JJ	JJ	_	5	amod	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	297+/-54	297+/-54	CD	CD	_	2	dep	_	_
8	;	;	:	:	_	7	punct	_	_
9	p	p	NN	NN	_	10	dep	_	_
10	&lt;	&lt;	JJR	JJR	_	7	dep	_	_
11	.001	.001	CD	CD	_	10	nummod	_	_
12	versus	versus	CC	CC	_	13	case	_	_
13	LPS	lps	NN	NN	_	10	dep	_	_
14	alone	alone	RB	RB	_	13	advmod	_	_
15	)	)	-RRB-	-RRB-	_	7	punct	_	_
16	.	.	.	.	_	2	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	LPS	lps	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	11	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	IkappaB-alpha	ikappab-alpha	NN	NN	_	10	compound	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	11	nsubj	_	_
11	decreased	decrease	VBD	VBD	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	17	nsubj	_	_
17	increased	increase	VBD	VBD	_	11	conj	_	_
18	.	.	.	.	_	11	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	pretreatment	pretreatment	NN	NN	_	3	nsubj	_	_
3	prevented	prevent	VBD	VBD	_	0	root	_	_
4	LPS-induced	lps-induced	JJ	JJ	_	5	amod	_	_
5	decreases	decrease	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	IkappaB-alpha	ikappab-alpha	NN	NN	_	9	compound	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	attenuated	attenuate	VBD	VBD	_	3	conj	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	binding	binding	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	prevent	prevent	VB	VB	_	2	xcomp	_	_
5	activation	activation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	preserving	preserve	VBG	VBG	_	4	advcl	_	_
10	IkappaB-alpha	ikappab-alpha	NN	NN	_	12	compound	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	9	dobj	_	_
13	,	,	,	,	_	4	punct	_	_
14	leading	lead	VBG	VBG	_	4	advcl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	reduction	reduction	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	20	compound	_	_
20	release	release	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Functional	functional	JJ	JJ	_	3	amod	_	_
2	testosterone	testosterone	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	plasma	plasma	NN	NN	_	6	compound	_	_
6	membranes	membrane	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	considered	consider	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	unresponsive	unresponsive	JJ	JJ	_	4	xcomp	_	_
8	to	to	TO	TO	_	9	case	_	_
9	testosterone	testosterone	NN	NN	_	7	nmod	_	_
10	due	due	JJ	JJ	_	13	case	_	_
11	to	to	TO	TO	_	10	mwe	_	_
12	the	the	DT	DT	_	13	det	_	_
13	absence	absence	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	androgen	androgen	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	AR	ar	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	testosterone	testosterone	NN	NN	_	7	compound	_	_
7	responsiveness	responsiveness	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	murine	murine	JJ	JJ	_	12	amod	_	_
10	splenic	splenic	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	7	advmod	_	_
15	as	as	RB	RB	_	7	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	the	the	DT	DT	_	19	det	_	_
19	presence	presence	NN	NN	_	7	conj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	unconventional	unconventional	JJ	JJ	_	24	amod	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	surface	surface	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	19	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	testosterone	testosterone	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	classical	classical	JJ	JJ	_	30	amod	_	_
29	intracellular	intracellular	JJ	JJ	_	30	amod	_	_
30	AR	ar	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	Binding	bind	VBG	VBG	_	2	amod	_	_
2	sites	site	NNS	NNS	_	19	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	testosterone	testosterone	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	surface	surface	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	CD4(+)	cd4(+)	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CD8(+)	cd8(+)	JJ	JJ	_	10	conj	_	_
13	subsets	subset	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	are	be	VBP	VBP	_	19	auxpass	_	_
18	directly	directly	RB	RB	_	19	advmod	_	_
19	revealed	reveal	VBN	VBN	_	0	root	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	impeded	impeded	JJ	JJ	_	24	amod	_	_
23	ligand	ligand	NN	NN	_	24	compound	_	_
24	testosterone-BSA-FITC	testosterone-bsa-fitc	NN	NN	_	19	nmod	_	_
25	by	by	IN	IN	_	29	case	_	_
26	confocal	confocal	JJ	JJ	_	29	amod	_	_
27	laser	laser	NN	NN	_	29	compound	_	_
28	scanning	scanning	NN	NN	_	29	compound	_	_
29	microscopy	microscopy	NN	NN	_	19	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CLSM	clsm	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	flow	flow	NN	NN	_	35	compound	_	_
35	cytometry	cytometry	NN	NN	_	29	conj	_	_
36	,	,	,	,	_	19	punct	_	_
37	respectively	respectively	RB	RB	_	19	advmod	_	_
38	.	.	.	.	_	19	punct	_	_

1	Binding	binding	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	plasma	plasma	NN	NN	_	8	compound	_	_
5	membrane	membrane	NN	NN	_	8	compound	_	_
6	impermeable	impermeable	JJ	JJ	_	8	amod	_	_
7	testosterone-BSA	testosterone-bsa	NN	NN	_	8	compound	_	_
8	conjugate	conjugate	NN	NN	_	1	nmod	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	rapid	rapid	JJ	JJ	_	12	amod	_	_
12	rise	rise	NN	NN	_	9	dobj	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	&lt;	&lt;	JJR	JJR	_	15	advmod	_	_
15	5	5	CD	CD	_	16	nummod	_	_
16	s	s	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	-LSB-Ca2+-RSB-i	-lsb-ca2+-rsb-i	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	Fura-2-loaded	fura-2-loaded	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	rise	rise	NN	NN	_	3	nsubj	_	_
3	reflects	reflect	VBZ	VBZ	_	0	root	_	_
4	influx	influx	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	extracellular	extracellular	JJ	JJ	_	7	amod	_	_
7	Ca2+	ca2+	NN	NN	_	4	nmod	_	_
8	through	through	IN	IN	_	13	case	_	_
9	non-voltage-gated	non-voltage-gated	JJ	JJ	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Ni2+-blockable	ni2+-blockable	JJ	JJ	_	9	conj	_	_
12	Ca2+	ca2+	NN	NN	_	13	compound	_	_
13	channels	channel	NNS	NNS	_	4	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	plasma	plasma	NN	NN	_	17	compound	_	_
17	membrane	membrane	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	testosterone-BSA-induced	testosterone-bsa-induced	JJ	JJ	_	4	amod	_	_
3	Ca2+	ca2+	NN	NN	_	4	compound	_	_
4	import	import	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	affected	affect	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	cyproterone	cyproterone	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	blocker	blocker	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	AR	ar	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	AR	ar	NNS	NNS	_	7	nsubj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	detectable	detectable	JJ	JJ	_	0	root	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	surface	surface	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	intact	intact	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	when	when	WRB	WRB	_	16	advmod	_	_
16	using	use	VBG	VBG	_	7	advcl	_	_
17	anti-AR	anti-ar	JJ	JJ	_	18	amod	_	_
18	antibodies	antibody	NNS	NNS	_	16	dobj	_	_
19	directed	direct	VBN	VBN	_	18	acl	_	_
20	against	against	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	amino	amino	NN	NN	_	25	amod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	carboxy	carboxy	NN	NN	_	22	conj	_	_
25	terminus	terminus	NN	NN	_	19	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	AR	ar	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	7	punct	_	_
30	although	although	IN	IN	_	33	mark	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	33	nsubj	_	_
33	contain	contain	VBP	VBP	_	7	advcl	_	_
34	AR	ar	NNS	NNS	_	33	dobj	_	_
35	,	,	,	,	_	33	punct	_	_
36	as	as	IN	IN	_	37	mark	_	_
37	revealed	reveal	VBN	VBN	_	33	advcl	_	_
38	by	by	IN	IN	_	42	case	_	_
39	reverse	reverse	JJ	JJ	_	42	amod	_	_
40	transcription-polymerase	transcription-polymerase	JJ	JJ	_	42	amod	_	_
41	chain	chain	NN	NN	_	42	compound	_	_
42	reactions	reaction	NNS	NNS	_	37	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	Western	western	NN	NN	_	45	compound	_	_
45	blotting	blotting	NN	NN	_	42	conj	_	_
46	.	.	.	.	_	7	punct	_	_

1	AR	ar	NN	NN	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	visualized	visualize	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	anti-AR	anti-ar	JJ	JJ	_	8	amod	_	_
8	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cytoplasm	cytoplasm	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	permeabilized	permeabilized	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	4	advcl	_	_
18	CLSM	clsm	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	4	punct	_	_
20	though	though	IN	IN	_	24	mark	_	_
21	AR	ar	NNS	NNS	_	24	nsubj	_	_
22	are	be	VBP	VBP	_	24	cop	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	detectable	detectable	JJ	JJ	_	4	advcl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cytosol	cytosol	NN	NN	_	27	compound	_	_
27	fractions	fraction	NNS	NNS	_	24	nmod	_	_
28	when	when	WRB	WRB	_	29	advmod	_	_
29	using	use	VBG	VBG	_	24	advcl	_	_
30	the	the	DT	DT	_	33	det	_	_
31	charcoal	charcoal	NN	NN	_	33	compound	_	_
32	binding	binding	NN	NN	_	33	compound	_	_
33	assay	assay	NN	NN	_	29	dobj	_	_
34	with	with	IN	IN	_	35	case	_	_
35	3H-R1881	3h-r1881	NN	NN	_	33	nmod	_	_
36	as	as	IN	IN	_	37	case	_	_
37	ligand	ligand	NN	NN	_	29	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	Cytoplasmic	cytoplasmic	JJ	JJ	_	2	amod	_	_
2	AR	ar	NNS	NNS	_	5	nsubj	_	_
3	do	do	VBP	VBP	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	translocate	translocate	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nucleus	nucleus	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	dep	_	_
14	presence	presence	NN	NN	_	16	dep	_	_
15	of	of	IN	IN	_	16	case	_	_
16	testosterone	testosterone	NN	NN	_	5	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	in	in	IN	IN	_	22	case	_	_
19	contrast	contrast	NN	NN	_	22	dep	_	_
20	to	to	TO	TO	_	22	case	_	_
21	cytoplasmic	cytoplasmic	JJ	JJ	_	22	amod	_	_
22	AR	ar	NNS	NNS	_	5	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	human	human	JJ	JJ	_	27	amod	_	_
25	cancer	cancer	NN	NN	_	27	compound	_	_
26	LNCaP	lncap	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	classical	classical	JJ	JJ	_	7	amod	_	_
7	AR	ar	NNS	NNS	_	15	nsubj	_	_
8	present	present	JJ	JJ	_	7	amod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	splenic	splenic	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	active	active	JJ	JJ	_	3	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	genomic	genomic	JJ	JJ	_	19	amod	_	_
19	pathway	pathway	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	surface	surface	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	15	nsubj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	testosterone	testosterone	NN	NN	_	7	nmod	_	_
10	are	be	VBP	VBP	_	15	cop	_	_
11	in	in	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	functionally	functionally	RB	RB	_	14	advmod	_	_
14	active	active	JJ	JJ	_	15	amod	_	_
15	state	state	NN	NN	_	0	root	_	_
16	,	,	,	,	_	15	punct	_	_
17	enabling	enable	VBG	VBG	_	15	xcomp	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	22	nsubj	_	_
20	a	a	DT	DT	_	22	det	_	_
21	nongenomic	nongenomic	JJ	JJ	_	22	amod	_	_
22	response	response	NN	NN	_	17	xcomp	_	_
23	to	to	TO	TO	_	24	case	_	_
24	testosterone	testosterone	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	fas-ligand	fas-ligand	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	during	during	IN	IN	_	8	case	_	_
6	activation-induced	activation-induced	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	death	death	NN	NN	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	via	via	IN	IN	_	15	case	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	kappaB	kappab	NN	NN	_	1	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	T	t	NN	NN	_	4	compound	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	engagement	engagement	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	5	dobj	_	_
8	important	important	JJ	JJ	_	7	amod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	cytokine	cytokine	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	regulation	regulation	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Additionally	additionally	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	signaling	signaling	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	activation-induced	activation-induced	JJ	JJ	_	10	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	dependent	dependent	JJ	JJ	_	10	acl:relcl	_	_
17	on	on	IN	IN	_	18	case	_	_
18	FasL	fasl	NN	NN	_	16	nmod	_	_
19	transcription	transcription	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	expression	expression	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	29	mark	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	kappaB	kappab	NN	NN	_	29	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	which	which	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	involved	involve	VBN	VBN	_	7	acl:relcl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	regulation	regulation	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	many	many	JJ	JJ	_	22	amod	_	_
21	cytokine	cytokine	NN	NN	_	22	compound	_	_
22	genes	gene	NNS	NNS	_	18	nmod	_	_
23	expressed	express	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	activated	activate	VBN	VBN	_	26	amod	_	_
26	lymphocytes	lymphocyte	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	7	punct	_	_
28	also	also	RB	RB	_	29	advmod	_	_
29	plays	play	VBZ	VBZ	_	3	ccomp	_	_
30	a	a	DT	DT	_	31	det	_	_
31	role	role	NN	NN	_	29	dobj	_	_
32	in	in	IN	IN	_	37	case	_	_
33	T	t	NN	NN	_	35	nmod:npmod	_	_
34	cell	cell	NN	NN	_	35	nmod:npmod	_	_
35	activation-induced	activation-induced	JJ	JJ	_	37	amod	_	_
36	FasL	fasl	NN	NN	_	37	compound	_	_
37	expression	expression	NN	NN	_	29	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	hybridoma	hybridoma	NN	NN	_	4	nmod	_	_
10	leads	lead	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	decreased	decrease	VBN	VBN	_	13	amod	_	_
13	FasL	fasl	NN	NN	_	10	nmod	_	_
14	expression	expression	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	apoptosis	apoptosis	NN	NN	_	14	conj	_	_
17	upon	upon	IN	IN	_	21	case	_	_
18	T	t	NN	NN	_	21	compound	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	10	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	FasL	fasl	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	2	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	contributes	contribute	VBZ	VBZ	_	9	acl:relcl	_	_
12	to	to	TO	TO	_	14	case	_	_
13	such	such	JJ	JJ	_	14	amod	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Co-expression	co-expression	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	p65	p65	NN	NN	_	6	compound	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	Rel	rel	NN	NN	_	6	compound	_	_
6	A	a	NN	NN	_	1	nmod	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	with	with	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	FasL	fasl	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	1	nmod	_	_
12	enhanced	enhance	VBD	VBD	_	0	root	_	_
13	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	co-expression	co-expression	NN	NN	_	21	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IkappaB	ikappab	NN	NN	_	17	nmod	_	_
20	dramatically	dramatically	RB	RB	_	21	advmod	_	_
21	inhibited	inhibit	VBD	VBD	_	12	conj	_	_
22	the	the	DT	DT	_	25	det	_	_
23	inducible	inducible	JJ	JJ	_	25	amod	_	_
24	promoter	promoter	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	AP-1	ap-1	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	15	case	_	_
12	activation-induced	activation-induced	JJ	JJ	_	15	amod	_	_
13	FasL	fasl	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	define	define	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	mediating	mediate	VBG	VBG	_	5	acl	_	_
10	FasL	fasl	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	during	during	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	X-rays-induced	x-rays-induced	JJ	JJ	_	2	amod	_	_
2	secretion	secretion	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	cellular	cellular	JJ	JJ	_	7	amod	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	s	s	NNS	NNS	_	2	nmod	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	that	that	WDT	WDT	_	16	nsubj	_	_
10	enhance	enhance	VBP	VBP	_	16	dep	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	s	be	VBZ	VBZ	_	16	cop	_	_
13	)	)	-RRB-	-RRB-	_	16	punct	_	_
14	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	transcription	transcription	NN	NN	_	7	acl:relcl	_	_
17	in	in	IN	IN	_	22	case	_	_
18	various	various	JJ	JJ	_	22	amod	_	_
19	non-irradiated	non-irradiated	JJ	JJ	_	22	amod	_	_
20	transfected	transfect	VBN	VBN	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Various	various	JJ	JJ	_	4	amod	_	_
2	cellular	cellular	JJ	JJ	_	4	amod	_	_
3	stress	stress	NN	NN	_	4	compound	_	_
4	agents	agent	NNS	NNS	_	10	nsubj	_	_
5	like	like	IN	IN	_	8	case	_	_
6	ionizing	ionize	VBG	VBG	_	8	amod	_	_
7	radiation	radiation	NN	NN	_	8	compound	_	_
8	exposure	exposure	NN	NN	_	4	nmod	_	_
9	could	could	MD	MD	_	10	aux	_	_
10	activate	activate	VB	VB	_	0	root	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	immunodeficiency	immunodeficiency	NN	NN	_	14	compound	_	_
13	virus	virus	NN	NN	_	14	compound	_	_
14	type	type	NN	NN	_	19	compound	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	HIV-1	hiv-1	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	replication	replication	NN	NN	_	10	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	reporter	reporter	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	conj	_	_
24	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	extracellular	extracellular	JJ	JJ	_	7	amod	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	s	s	NNS	NNS	_	21	nsubj	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	released	release	VBN	VBN	_	7	acl	_	_
10	by	by	IN	IN	_	16	case	_	_
11	X-ray-treated	x-ray-treated	JJ	JJ	_	16	amod	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	colonic	colonic	JJ	JJ	_	16	amod	_	_
14	carcinoma	carcinoma	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	HT29	ht29	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	might	might	MD	MD	_	21	aux	_	_
21	activate	activate	VB	VB	_	0	root	_	_
22	the	the	DT	DT	_	25	det	_	_
23	long	long	JJ	JJ	_	25	amod	_	_
24	terminal	terminal	JJ	JJ	_	25	amod	_	_
25	repeat	repeat	NN	NN	_	21	dobj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	LTR	ltr	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	of	of	IN	IN	_	30	case	_	_
30	HIV-1	hiv-1	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	non-irradiated	non-irradiated	JJ	JJ	_	34	amod	_	_
33	HT29	ht29	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	25	nmod	_	_
35	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	19	mark	_	_
8	in	in	IN	IN	_	15	case	_	_
9	various	various	JJ	JJ	_	15	amod	_	_
10	transiently	transiently	RB	RB	_	11	advmod	_	_
11	or	or	CC	CC	_	13	advmod	_	_
12	stably	stably	RB	RB	_	11	advmod	_	_
13	transfected	transfect	VBN	VBN	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	19	nmod	_	_
16	,	,	,	,	_	19	punct	_	_
17	X-ray	x-ray	NN	NN	_	18	compound	_	_
18	irradiation	irradiation	NN	NN	_	19	nsubj	_	_
19	up-regulates	up-regulate	VBZ	VBZ	_	6	ccomp	_	_
20	HIV-1	hiv-1	NN	NN	_	22	compound	_	_
21	LTR	ltr	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	19	dobj	_	_
23	through	through	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	kappaB	kappab	NN	NN	_	27	compound	_	_
26	regulatory	regulatory	JJ	JJ	_	27	amod	_	_
27	elements	element	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	factor	factor	NN	NN	_	4	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	s	s	NNS	NNS	_	21	nsubjpass	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	4	punct	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	processed	process	VBN	VBN	_	4	acl:relcl	_	_
10	by	by	IN	IN	_	9	nmod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	acts	act	VBZ	VBZ	_	9	conj	_	_
13	upon	upon	IN	IN	_	12	nmod	_	_
14	a	a	DT	DT	_	15	det	_	_
15	variety	variety	NN	NN	_	9	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	types	type	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	detected	detect	VBN	VBN	_	0	root	_	_
22	by	by	IN	IN	_	23	case	_	_
23	addition	addition	NN	NN	_	21	nmod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	non-irradiated	non-irradiated	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	either	either	CC	CC	_	30	cc:preconj	_	_
29	X-ray-treated	x-ray-treated	JJ	JJ	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	a	a	DT	DT	_	34	det	_	_
33	conditioned	conditioned	JJ	JJ	_	34	amod	_	_
34	medium	medium	NN	NN	_	30	conj	_	_
35	taken	take	VBN	VBN	_	34	acl	_	_
36	from	from	IN	IN	_	38	case	_	_
37	irradiated	irradiated	JJ	JJ	_	38	amod	_	_
38	cultures	culture	NNS	NNS	_	35	nmod	_	_
39	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	responsiveness	responsiveness	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	cell	cell	NN	NN	_	8	nmod:npmod	_	_
7	type	type	NN	NN	_	8	nmod:npmod	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	X-ray	x-ray	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	17	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	LTR	ltr	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	15	case	_	_
10	transiently	transiently	RB	RB	_	11	advmod	_	_
11	or	or	CC	CC	_	13	advmod	_	_
12	stably	stably	RB	RB	_	11	advmod	_	_
13	transfected	transfect	VBN	VBN	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	8	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	inhibited	inhibit	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	potent	potent	JJ	JJ	_	22	amod	_	_
21	antioxidant	antioxidant	JJ	JJ	_	22	amod	_	_
22	drug	drug	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	pyrrolidine	pyrrolidine	NN	NN	_	25	compound	_	_
25	dithiocarbamate	dithiocarbamate	NN	NN	_	22	appos	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	by	by	IN	IN	_	29	case	_	_
28	another	another	DT	DT	_	29	det	_	_
29	drug	drug	NN	NN	_	22	conj	_	_
30	,	,	,	,	_	29	punct	_	_
31	known	know	VBN	VBN	_	29	acl	_	_
32	for	for	IN	IN	_	34	case	_	_
33	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
34	role	role	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	trapping	trapping	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	growth	growth	NN	NN	_	40	compound	_	_
40	factors	factor	NNS	NNS	_	37	nmod	_	_
41	,	,	,	,	_	29	punct	_	_
42	suramin	suramin	NN	NN	_	29	dep	_	_
43	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	observations	observation	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	pathophysiology	pathophysiology	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	AIDS-related	aids-related	JJ	JJ	_	13	amod	_	_
13	cancers	cancer	NNS	NNS	_	10	nmod	_	_
14	treated	treat	VBN	VBN	_	10	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	radiotherapy	radiotherapy	NN	NN	_	14	nmod	_	_
17	remains	remain	VBZ	VBZ	_	0	root	_	_
18	to	to	TO	TO	_	20	mark	_	_
19	be	be	VB	VB	_	20	auxpass	_	_
20	established	establish	VBN	VBN	_	17	xcomp	_	_
21	.	.	.	.	_	17	punct	_	_

1	Characterisation	characterisation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	sequences	sequence	NNS	NNS	_	1	nmod	_	_
5	at	at	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	11	amod	_	_
8	virus	virus	NN	NN	_	11	compound	_	_
9	BamHI	bamhi	NN	NN	_	11	compound	_	_
10	W	w	NN	NN	_	11	compound	_	_
11	promoter	promoter	NN	NN	_	4	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	8	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	gammaherpesvirus	gammaherpesvirus	NN	NN	_	2	appos	_	_
7	,	,	,	,	_	2	punct	_	_
8	possesses	possess	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	unique	unique	JJ	JJ	_	11	amod	_	_
11	set	set	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	latent	latent	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	whose	whose	WP$	WP$	_	17	nmod:poss	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	21	nsubj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	leads	lead	VBZ	VBZ	_	14	acl:relcl	_	_
22	to	to	TO	TO	_	25	case	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	growth	growth	NN	NN	_	25	compound	_	_
25	transformation	transformation	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	initiation	initiation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	this	this	DT	DT	_	7	det	_	_
5	growth	growth	NN	NN	_	7	compound	_	_
6	transforming	transforming	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	2	nmod	_	_
8	depends	depend	VBZ	VBZ	_	0	root	_	_
9	on	on	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	viral	viral	JJ	JJ	_	12	amod	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	BamHI	bamhi	NN	NN	_	15	compound	_	_
15	W	w	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Wp	wp	NN	NN	_	12	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	whose	whose	WP$	WP$	_	20	nmod:poss	_	_
20	regulation	regulation	NN	NN	_	23	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	poorly	poorly	RB	RB	_	23	advmod	_	_
23	understood	understand	VBN	VBN	_	12	acl:relcl	_	_
24	.	.	.	.	_	8	punct	_	_

1	Using	use	VBG	VBG	_	12	advcl	_	_
2	Wp	wp	NN	NN	_	4	compound	_	_
3	reporter	reporter	NN	NN	_	4	compound	_	_
4	constructs	construct	NNS	NNS	_	1	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	in	in	FW	FW	_	9	amod	_	_
7	vitro	vitro	FW	FW	_	6	dep	_	_
8	transfection	transfection	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	1	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	found	find	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	20	mark	_	_
14	Wp	wp	NN	NN	_	20	nsubj	_	_
15	was	be	VBD	VBD	_	20	cop	_	_
16	11-	11-	CD	CD	_	19	nmod:npmod	_	_
17	to	to	TO	TO	_	16	dep	_	_
18	190-fold	190-fold	RB	RB	_	16	dep	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	active	active	JJ	JJ	_	12	ccomp	_	_
21	in	in	IN	IN	_	23	case	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cell	cell	NN	NN	_	20	nmod	_	_
24	than	than	IN	IN	_	28	case	_	_
25	in	in	IN	IN	_	28	case	_	_
26	non-B	non-b	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	20	advcl	_	_
29	and	and	CC	CC	_	20	cc	_	_
30	that	that	IN	IN	_	45	mark	_	_
31	three	three	CD	CD	_	32	nummod	_	_
32	regions	region	NNS	NNS	_	45	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	promoter	promoter	NN	NN	_	32	nmod	_	_
36	(	(	-LRB-	-LRB-	_	32	punct	_	_
37	termed	term	VBN	VBN	_	32	acl	_	_
38	UAS1	uas1	NN	NN	_	37	xcomp	_	_
39	,	,	,	,	_	38	punct	_	_
40	UAS2	uas2	NN	NN	_	38	conj	_	_
41	,	,	,	,	_	38	punct	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	UAS3	uas3	NN	NN	_	38	conj	_	_
44	)	)	-RRB-	-RRB-	_	32	punct	_	_
45	contributed	contribute	VBD	VBD	_	20	conj	_	_
46	to	to	TO	TO	_	48	case	_	_
47	transcriptional	transcriptional	JJ	JJ	_	48	amod	_	_
48	activation	activation	NN	NN	_	45	nmod	_	_
49	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	upstream	upstream	JJ	JJ	_	3	amod	_	_
3	regions	region	NNS	NNS	_	18	nsubj	_	_
4	UAS3	uas3	NN	NN	_	3	dep	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	-1168	-1168	CD	CD	_	8	compound	_	_
7	to	to	TO	TO	_	8	dep	_	_
8	-440	-440	CD	CD	_	4	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	UAS2	uas2	NN	NN	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	-352	-352	CD	CD	_	15	compound	_	_
14	to	to	TO	TO	_	15	dep	_	_
15	-264	-264	CD	CD	_	11	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	both	both	DT	DT	_	3	dep	_	_
18	functioned	function	VBD	VBD	_	0	root	_	_
19	in	in	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	cell	cell	NN	NN	_	22	nmod:npmod	_	_
22	lineage-independent	lineage-independent	JJ	JJ	_	23	amod	_	_
23	manner	manner	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	were	be	VBD	VBD	_	27	cop	_	_
26	together	together	RB	RB	_	27	advmod	_	_
27	responsible	responsible	JJ	JJ	_	18	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	bulk	bulk	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	Wp	wp	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	30	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	non-B	non-b	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	;	;	:	:	_	18	punct	_	_
38	mutational	mutational	JJ	JJ	_	39	amod	_	_
39	analysis	analysis	NN	NN	_	40	nsubj	_	_
40	indicated	indicate	VBD	VBD	_	18	parataxis	_	_
41	the	the	DT	DT	_	42	det	_	_
42	importance	importance	NN	NN	_	40	dobj	_	_
43	of	of	IN	IN	_	47	case	_	_
44	a	a	DT	DT	_	47	det	_	_
45	YY1	yy1	NN	NN	_	47	compound	_	_
46	binding	binding	NN	NN	_	47	compound	_	_
47	site	site	NN	NN	_	42	nmod	_	_
48	in	in	IN	IN	_	49	case	_	_
49	UAS2	uas2	NN	NN	_	42	nmod	_	_
50	in	in	IN	IN	_	52	case	_	_
51	that	that	DT	DT	_	52	det	_	_
52	context	context	NN	NN	_	42	nmod	_	_
53	.	.	.	.	_	18	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	UAS1	uas1	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	-140	-140	CD	CD	_	8	compound	_	_
7	to	to	TO	TO	_	8	dep	_	_
8	-87	-87	CD	CD	_	4	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	was	be	VBD	VBD	_	13	cop	_	_
11	B	b	NN	NN	_	13	nmod:npmod	_	_
12	cell	cell	NN	NN	_	13	nmod:npmod	_	_
13	specific	specific	JJ	JJ	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	was	be	VBD	VBD	_	18	cop	_	_
16	the	the	DT	DT	_	18	det	_	_
17	key	key	JJ	JJ	_	18	amod	_	_
18	determinant	determinant	NN	NN	_	13	conj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	promoter	promoter	NN	NN	_	24	nmod:poss	_	_
22	's	's	POS	POS	_	21	case	_	_
23	increased	increase	VBN	VBN	_	24	amod	_	_
24	activity	activity	NN	NN	_	18	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	B	b	NN	NN	_	28	compound	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	lines	line	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	UAS1	uas1	NN	NN	_	5	compound	_	_
5	sequences	sequence	NNS	NNS	_	2	nmod	_	_
6	combined	combine	VBN	VBN	_	2	acl	_	_
7	with	with	IN	IN	_	11	case	_	_
8	in	in	FW	FW	_	11	amod	_	_
9	vitro	vitro	FW	FW	_	8	dep	_	_
10	bandshift	bandshift	NN	NN	_	11	compound	_	_
11	assays	assay	NNS	NNS	_	6	nmod	_	_
12	revealed	reveal	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	three	three	CD	CD	_	18	nummod	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	14	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	factors	factor	NNS	NNS	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	this	this	DT	DT	_	24	det	_	_
24	region	region	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	When	when	WRB	WRB	_	11	advmod	_	_
2	mutations	mutation	NNS	NNS	_	11	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	abolished	abolish	VBD	VBD	_	2	acl:relcl	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	bandshift	bandshift	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	4	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	introduced	introduce	VBN	VBN	_	30	advcl	_	_
12	into	into	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	Wp	wp	NN	NN	_	16	compound	_	_
15	reporter	reporter	NN	NN	_	16	compound	_	_
16	construct	construct	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	30	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	loss	loss	NN	NN	_	30	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	any	any	DT	DT	_	22	det	_	_
22	one	one	CD	CD	_	19	nmod	_	_
23	of	of	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	three	three	CD	CD	_	28	nummod	_	_
26	UAS1	uas1	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	sites	site	NNS	NNS	_	22	nmod	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	sufficient	sufficient	JJ	JJ	_	0	root	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	reduce	reduce	VB	VB	_	30	xcomp	_	_
33	promoter	promoter	NN	NN	_	34	compound	_	_
34	activity	activity	NN	NN	_	32	dobj	_	_
35	by	by	IN	IN	_	36	case	_	_
36	10-	10-	CD	CD	_	32	nmod	_	_
37	to	to	TO	TO	_	36	dep	_	_
38	30-fold	30-fold	RB	RB	_	36	dep	_	_
39	in	in	IN	IN	_	41	case	_	_
40	B	b	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	32	nmod	_	_
42	.	.	.	.	_	30	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	two	two	CD	CD	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	these	these	DT	DT	_	5	nmod	_	_
8	appear	appear	VBP	VBP	_	0	root	_	_
9	to	to	TO	TO	_	15	mark	_	_
10	be	be	VB	VB	_	15	cop	_	_
11	novel	novel	JJ	JJ	_	15	amod	_	_
12	transcription	transcription	NN	NN	_	15	compound	_	_
13	factor	factor	NN	NN	_	15	compound	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	sites	site	NNS	NNS	_	8	xcomp	_	_
16	,	,	,	,	_	8	punct	_	_
17	whereas	whereas	IN	IN	_	8	dep	_	_
18	the	the	DT	DT	_	19	det	_	_
19	third	third	JJ	JJ	_	21	nsubjpass	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	identified	identify	VBN	VBN	_	8	parataxis	_	_
22	as	as	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	cyclic	cyclic	JJ	JJ	_	27	amod	_	_
25	AMP	amp	NN	NN	_	27	compound	_	_
26	response	response	NN	NN	_	27	compound	_	_
27	element	element	NN	NN	_	21	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	CRE	cre	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	CRE	cre	NN	NN	_	7	nsubj	_	_
7	interacts	interact	VBZ	VBZ	_	3	ccomp	_	_
8	with	with	IN	IN	_	12	case	_	_
9	CREB	creb	NN	NN	_	12	compound	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	ATF1	atf1	NN	NN	_	9	conj	_	_
12	proteins	protein	NNS	NNS	_	7	nmod	_	_
13	present	present	JJ	JJ	_	12	amod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	B	b	NN	NN	_	18	compound	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	that	that	IN	IN	_	24	mark	_	_
21	this	this	DT	DT	_	22	det	_	_
22	interaction	interaction	NN	NN	_	24	nsubj	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	important	important	JJ	JJ	_	7	conj	_	_
25	for	for	IN	IN	_	27	case	_	_
26	Wp	wp	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factor	factor	NN	NN	_	0	root	_	_
3	binding	bind	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	core	core	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	monoamine	monoamine	NN	NN	_	14	compound	_	_
12	oxidase	oxidase	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	7	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	cerebral	cerebral	JJ	JJ	_	18	amod	_	_
18	cortex	cortex	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	blood	blood	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	2	punct	_	_

1	Many	many	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	monoamine	monoamine	NN	NN	_	7	compound	_	_
6	oxidase	oxidase	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	14	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	biological	biological	JJ	JJ	_	14	amod	_	_
14	marker	marker	NN	NN	_	3	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	personality	personality	NN	NN	_	17	compound	_	_
17	characteristics	characteristic	NNS	NNS	_	14	nmod	_	_
18	such	such	JJ	JJ	_	21	case	_	_
19	as	as	IN	IN	_	18	mwe	_	_
20	sensation	sensation	NN	NN	_	21	compound	_	_
21	seeking	seeking	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	10	nsubjpass	_	_
3	underlying	underlie	VBG	VBG	_	2	acl	_	_
4	this	this	DT	DT	_	5	det	_	_
5	association	association	NN	NN	_	3	dobj	_	_
6	is	be	VBZ	VBZ	_	10	auxpass	_	_
7	so	so	RB	RB	_	8	advmod	_	_
8	far	far	RB	RB	_	10	advmod	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	explored	explore	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	performed	perform	VBN	VBN	_	0	root	_	_
8	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
9	mobility-shift	mobility-shift	JJ	JJ	_	10	amod	_	_
10	assays	assay	NNS	NNS	_	7	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	investigate	investigate	VB	VB	_	7	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pattern	pattern	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	binding	binding	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	150	150	CD	CD	_	22	nummod	_	_
21	bp	bp	NN	NN	_	22	compound	_	_
22	fragment	fragment	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	proximal	proximal	JJ	JJ	_	27	amod	_	_
26	5'-flanking	5'-flanking	JJ	JJ	_	27	amod	_	_
27	region	region	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	34	case	_	_
29	the	the	DT	DT	_	34	det	_	_
30	human	human	JJ	JJ	_	34	amod	_	_
31	monoamine	monoamine	NN	NN	_	34	compound	_	_
32	oxidase	oxidase	NN	NN	_	34	compound	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	gene	gene	NN	NN	_	27	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	compared	compare	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	pattern	pattern	NN	NN	_	2	dobj	_	_
5	using	use	VBG	VBG	_	2	xcomp	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	5	dobj	_	_
8	from	from	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	brain	brain	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	10	conj	_	_
13	.	.	.	.	_	2	punct	_	_

1	Interestingly	interestingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	correlation	correlation	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	between	between	IN	IN	_	12	case	_	_
8	monoamine	monoamine	NN	NN	_	12	compound	_	_
9	oxidase	oxidase	NN	NN	_	12	compound	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	enzyme	enzyme	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	platelets	platelet	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	pattern	pattern	NN	NN	_	12	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	two	two	CD	CD	_	27	nummod	_	_
25	uncharacterized	uncharacterized	JJ	JJ	_	27	amod	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	6	nsubj	_	_
3	are	be	VBP	VBP	_	6	cop	_	_
4	well	well	RB	RB	_	6	advmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	line	line	NN	NN	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	long-standing	long-standing	JJ	JJ	_	10	amod	_	_
10	notion	notion	NN	NN	_	6	nmod	_	_
11	that	that	IN	IN	_	19	mark	_	_
12	interindividual	interindividual	JJ	JJ	_	13	amod	_	_
13	differences	difference	NNS	NNS	_	19	nsubj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	platelet	platelet	NN	NN	_	17	compound	_	_
16	monoamine	monoamine	NN	NN	_	17	compound	_	_
17	oxidase	oxidase	NN	NN	_	13	nmod	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	represent	represent	VB	VB	_	10	ccomp	_	_
20	differences	difference	NNS	NNS	_	19	dobj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	expression	expression	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	enzyme	enzyme	NN	NN	_	22	nmod	_	_
26	rather	rather	RB	RB	_	22	cc	_	_
27	than	than	IN	IN	_	26	mwe	_	_
28	genotypic	genotypic	JJ	JJ	_	29	amod	_	_
29	variation	variation	NN	NN	_	22	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Reactivation	reactivation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	Kaposi	kaposi	NN	NN	_	5	nmod:npmod	_	_
4	's	's	POS	POS	_	3	case	_	_
5	sarcoma-associated	sarcoma-associated	JJ	JJ	_	7	amod	_	_
6	herpesvirus	herpesvirus	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	1	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	latency	latency	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	expression	expression	NN	NN	_	1	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	ORF	orf	NN	NN	_	16	compound	_	_
15	50	50	CD	CD	_	16	nummod	_	_
16	transactivator	transactivator	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	19	det	_	_
19	homolog	homolog	NN	NN	_	16	appos	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	EBV	ebv	NN	NN	_	24	compound	_	_
23	R	r	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Kaposi	kaposi	NN	NN	_	3	nmod:poss	_	_
2	's	's	POS	POS	_	1	case	_	_
3	sarcoma	sarcoma	NN	NN	_	7	dep	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	KS	ks	NN	NN	_	7	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-associated	-associated	JJ	JJ	_	8	amod	_	_
8	herpesvirus	herpesvirus	NN	NN	_	21	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	KSHV	kshv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	or	or	CC	CC	_	8	cc	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	herpesvirus	herpesvirus	NN	NN	_	8	conj	_	_
16	8	8	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	8	punct	_	_
18	is	be	VBZ	VBZ	_	21	cop	_	_
19	a	a	DT	DT	_	21	det	_	_
20	lymphotropic	lymphotropic	JJ	JJ	_	21	amod	_	_
21	virus	virus	NN	NN	_	0	root	_	_
22	strongly	strongly	RB	RB	_	23	advmod	_	_
23	linked	link	VBN	VBN	_	21	acl	_	_
24	to	to	TO	TO	_	27	case	_	_
25	several	several	JJ	JJ	_	27	amod	_	_
26	AIDS-related	aids-related	JJ	JJ	_	27	amod	_	_
27	neoplasms	neoplasm	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	primary	primary	JJ	JJ	_	3	amod	_	_
3	reservoir	reservoir	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	infection	infection	NN	NN	_	3	nmod	_	_
6	consists	consist	VBZ	VBZ	_	0	root	_	_
7	of	of	IN	IN	_	11	case	_	_
8	latently	latently	RB	RB	_	9	advmod	_	_
9	infected	infected	JJ	JJ	_	11	amod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	possibly	possibly	RB	RB	_	16	advmod	_	_
14	other	other	JJ	JJ	_	16	amod	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	6	conj	_	_
17	.	.	.	.	_	6	punct	_	_

1	Viral	viral	JJ	JJ	_	2	amod	_	_
2	reactivation	reactivation	NN	NN	_	13	nsubjpass	_	_
3	from	from	IN	IN	_	4	case	_	_
4	latency	latency	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	spread	spread	NN	NN	_	4	conj	_	_
7	from	from	IN	IN	_	10	case	_	_
8	this	this	DT	DT	_	10	det	_	_
9	lymphoid	lymphoid	JJ	JJ	_	10	amod	_	_
10	reservoir	reservoir	NN	NN	_	4	nmod	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	presumably	presumably	RB	RB	_	13	advmod	_	_
13	required	require	VBN	VBN	_	0	root	_	_
14	for	for	IN	IN	_	15	case	_	_
15	development	development	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	nonlymphoid	nonlymphoid	JJ	JJ	_	18	amod	_	_
18	tumors	tumor	NNS	NNS	_	15	nmod	_	_
19	like	like	IN	IN	_	20	case	_	_
20	KS	ks	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	28	mark	_	_
5	deregulated	deregulate	VBN	VBN	_	6	amod	_	_
6	expression	expression	NN	NN	_	28	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	single	single	JJ	JJ	_	11	amod	_	_
10	viral	viral	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	ORF	orf	NN	NN	_	11	appos	_	_
14	50	50	CD	CD	_	13	nummod	_	_
15	,	,	,	,	_	11	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	encodes	encode	VBZ	VBZ	_	11	acl:relcl	_	_
18	a	a	DT	DT	_	19	det	_	_
19	transactivator	transactivator	NN	NN	_	17	dobj	_	_
20	able	able	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	selectively	selectively	RB	RB	_	23	advmod	_	_
23	upregulate	upregulate	VB	VB	_	20	xcomp	_	_
24	delayed-early	delayed-early	JJ	JJ	_	26	amod	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	genes	gene	NNS	NNS	_	23	dobj	_	_
27	,	,	,	,	_	11	punct	_	_
28	suffices	suffice	VBZ	VBZ	_	3	ccomp	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	disrupt	disrupt	VB	VB	_	28	xcomp	_	_
31	latency	latency	NN	NN	_	30	dobj	_	_
32	and	and	CC	CC	_	30	cc	_	_
33	induce	induce	VB	VB	_	30	conj	_	_
34	the	the	DT	DT	_	37	det	_	_
35	lytic	lytic	JJ	JJ	_	37	amod	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	cascade	cascade	NN	NN	_	33	dobj	_	_
38	in	in	IN	IN	_	42	case	_	_
39	latently	latently	RB	RB	_	42	advmod	_	_
40	infected	infected	JJ	JJ	_	42	amod	_	_
41	B	b	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	identification	identification	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	gene	gene	NN	NN	_	2	nmod	_	_
6	opens	open	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	way	way	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	10	case	_	_
10	studies	study	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	15	mark	_	_
12	the	the	DT	DT	_	14	det	_	_
13	physiologic	physiologic	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	15	nsubj	_	_
15	controlling	control	VBG	VBG	_	10	acl	_	_
16	reactvation	reactvation	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	KSHV	kshv	NN	NN	_	16	nmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	latency	latency	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	interleukin-1beta	interleukin-1beta	NN	NN	_	4	compound	_	_
4	transcription	transcription	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	1	nmod	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	latent	latent	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	10	nmod	_	_
14	via	via	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	interaction	interaction	NN	NN	_	8	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	RBP	rbp	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	2	amod	_	_
2	virus	virus	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	EBV	ebv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	infects	infect	VBZ	VBZ	_	0	root	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	resulting	result	VBG	VBG	_	6	advcl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	outgrowth	outgrowth	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	immortalised	immortalised	JJ	JJ	_	18	amod	_	_
16	lymphoblastoid	lymphoblastoid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	LCLs	lcl	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	through	through	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	intracellular	intracellular	JJ	JJ	_	10	amod	_	_
10	staining	staining	NN	NN	_	7	nmod	_	_
11	that	that	IN	IN	_	17	mark	_	_
12	interleukin-1beta	interleukin-1beta	NN	NN	_	17	nsubjpass	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IL-1beta	il-1beta	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	4	ccomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	LCLs	lcl	NNS	NNS	_	17	nmod	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	investigate	investigate	VBP	VBP	_	4	conj	_	_
22	the	the	DT	DT	_	23	det	_	_
23	influence	influence	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	individual	individual	JJ	JJ	_	28	amod	_	_
27	latent	latent	JJ	JJ	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	23	nmod	_	_
29	on	on	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	expression	expression	NN	NN	_	23	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	IL-1beta	il-1beta	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	RT-PCR	rt-pcr	NN	NN	_	1	dobj	_	_
3	,	,	,	,	_	6	punct	_	_
4	IL-1beta	il-1beta	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	up-regulated	up-regulate	VBN	VBN	_	6	xcomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	EBV-transformed	ebv-transformed	JJ	JJ	_	12	amod	_	_
12	LCLs	lcl	NNS	NNS	_	9	nmod	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	in	in	IN	IN	_	26	case	_	_
17	group	group	NN	NN	_	26	compound	_	_
18	III	iii	CD	CD	_	26	nummod	_	_
19	Burkitt	burkitt	NN	NN	_	26	nmod:poss	_	_
20	's	's	POS	POS	_	26	case	_	_
21	lymphoma	lymphoma	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	BL	bl	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	12	conj	_	_
27	,	,	,	,	_	9	punct	_	_
28	compared	compare	VBN	VBN	_	34	case	_	_
29	with	with	IN	IN	_	34	case	_	_
30	group	group	NN	NN	_	34	compound	_	_
31	I	i	CD	CD	_	34	nummod	_	_
32	BL	bl	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	lines	line	NNS	NNS	_	9	advcl	_	_
35	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	up-regulation	up-regulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IL-1beta	il-1beta	NN	NN	_	5	compound	_	_
5	message	message	NN	NN	_	2	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	mediated	mediate	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	latent	latent	JJ	JJ	_	13	amod	_	_
12	membrane	membrane	NN	NN	_	13	compound	_	_
13	protein-1	protein-1	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	EBV	ebv	NN	NN	_	13	dep	_	_
16	nuclear	nuclear	JJ	JJ	_	15	dep	_	_
17	proteins	protein	NNS	NNS	_	15	dep	_	_
18	2	2	CD	CD	_	15	dep	_	_
19	,	,	,	,	_	15	punct	_	_
20	3	3	CD	CD	_	15	dep	_	_
21	,	,	,	,	_	15	punct	_	_
22	4	4	CD	CD	_	15	dep	_	_
23	,	,	,	,	_	15	punct	_	_
24	and	and	CC	CC	_	15	cc	_	_
25	6	6	CD	CD	_	15	conj	_	_
26	genes	gene	NNS	NNS	_	15	dep	_	_
27	.	.	.	.	_	8	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSAs	emsa	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	29	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	-300	-300	CD	CD	_	12	nummod	_	_
12	region	region	NN	NN	_	29	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	IL-1beta	il-1beta	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	contains	contain	VBZ	VBZ	_	12	acl:relcl	_	_
20	a	a	DT	DT	_	27	det	_	_
21	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
22	factor-kappaB	factor-kappab	NN	NN	_	27	compound	_	_
23	(	(	-LRB-	-LRB-	_	27	punct	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	27	compound	_	_
25	)	)	-RRB-	-RRB-	_	27	punct	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	site	site	NN	NN	_	19	dobj	_	_
28	,	,	,	,	_	12	punct	_	_
29	contained	contain	VBD	VBD	_	8	ccomp	_	_
30	a	a	DT	DT	_	34	det	_	_
31	functional	functional	JJ	JJ	_	34	amod	_	_
32	RBP	rbp	NN	NN	_	34	compound	_	_
33	binding	binding	NN	NN	_	34	compound	_	_
34	site	site	NN	NN	_	29	dobj	_	_
35	.	.	.	.	_	8	punct	_	_

1	Binding	binding	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	RBP	rbp	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	site	site	NN	NN	_	1	nmod	_	_
7	could	could	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	addition	addition	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	EBV	ebv	NN	NN	_	15	compound	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	3	3	CD	CD	_	15	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	6	6	CD	CD	_	16	conj	_	_
19	,	,	,	,	_	9	punct	_	_
20	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	these	these	DT	DT	_	23	det	_	_
23	proteins	protein	NNS	NNS	_	24	nsubj	_	_
24	displace	displace	VBP	VBP	_	20	ccomp	_	_
25	RBP	rbp	NN	NN	_	24	dobj	_	_
26	from	from	IN	IN	_	29	case	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	recognition	recognition	NN	NN	_	29	compound	_	_
29	sequence	sequence	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	24	punct	_	_
31	removing	remove	VBG	VBG	_	24	dep	_	_
32	transcriptional	transcriptional	JJ	JJ	_	33	amod	_	_
33	repression	repression	NN	NN	_	31	dobj	_	_
34	and	and	CC	CC	_	31	cc	_	_
35	allowing	allow	VBG	VBG	_	31	conj	_	_
36	gene	gene	NN	NN	_	37	compound	_	_
37	transcription	transcription	NN	NN	_	35	dobj	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	occur	occur	VB	VB	_	35	xcomp	_	_
40	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	group	group	NN	NN	_	5	compound	_	_
3	I	i	CD	CD	_	5	nummod	_	_
4	BL	bl	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	17	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	containing	contain	VBG	VBG	_	5	acl	_	_
8	low	low	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	only	only	RB	RB	_	15	advmod	_	_
14	RBP	rbp	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	observed	observe	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	EMSAs	emsa	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	17	punct	_	_
21	whereas	whereas	IN	IN	_	17	dep	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	26	nsubjpass	_	_
24	could	could	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	demonstrated	demonstrate	VBN	VBN	_	17	parataxis	_	_
27	in	in	IN	IN	_	31	case	_	_
28	EBV-transformed	ebv-transformed	JJ	JJ	_	31	amod	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	lines	line	NNS	NNS	_	26	nmod	_	_
32	containing	contain	VBG	VBG	_	31	acl	_	_
33	high	high	JJ	JJ	_	34	amod	_	_
34	levels	level	NNS	NNS	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	activated	activate	VBN	VBN	_	37	amod	_	_
37	NF-kappaB	nf-kappab	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	latent	latent	JJ	JJ	_	9	amod	_	_
8	membrane	membrane	NN	NN	_	9	compound	_	_
9	protein-1	protein-1	NN	NN	_	5	nmod	_	_
10	led	lead	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	that	that	WDT	WDT	_	17	nsubj	_	_
16	was	be	VBD	VBD	_	17	cop	_	_
17	capable	capable	JJ	JJ	_	14	acl:relcl	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	binding	bind	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IL-1beta	il-1beta	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	EBV	ebv	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	up-regulate	up-regulate	VB	VB	_	3	ccomp	_	_
8	IL-1beta	il-1beta	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	possibly	possibly	RB	RB	_	13	advmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	using	use	VBG	VBG	_	7	advcl	_	_
14	RBP	rbp	NN	NN	_	13	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	or	or	CC	CC	_	14	cc	_	_
19	both	both	DT	DT	_	14	conj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	X	x	NN	NN	_	4	compound	_	_
2	chromosome	chromosome	NN	NN	_	4	compound	_	_
3	inactivation	inactivation	NN	NN	_	4	compound	_	_
4	patterns	pattern	NNS	NNS	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	females	female	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	10	mark	_	_
2	one	one	CD	CD	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	X	x	NN	NN	_	7	compound	_	_
7	chromosomes	chromosome	NNS	NNS	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	randomly	randomly	RB	RB	_	10	advmod	_	_
10	inactivated	inactivate	VBN	VBN	_	24	advcl	_	_
11	at	at	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	early	early	JJ	JJ	_	14	amod	_	_
14	stage	stage	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	female	female	NN	NN	_	18	compound	_	_
17	embryonic	embryonic	JJ	JJ	_	18	amod	_	_
18	development	development	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	24	punct	_	_
20	X-linked	x-linked	JJ	JJ	_	21	amod	_	_
21	markers	marker	NNS	NNS	_	24	nsubjpass	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	used	use	VBN	VBN	_	0	root	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	study	study	VB	VB	_	24	xcomp	_	_
27	the	the	DT	DT	_	28	det	_	_
28	origin	origin	NN	NN	_	26	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	development	development	NN	NN	_	28	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	various	various	JJ	JJ	_	34	amod	_	_
33	neoplastic	neoplastic	JJ	JJ	_	34	amod	_	_
34	disorders	disorder	NNS	NNS	_	28	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	affected	affect	VBN	VBN	_	38	amod	_	_
37	heterozygous	heterozygous	JJ	JJ	_	38	amod	_	_
38	women	woman	NNS	NNS	_	34	nmod	_	_
39	;	;	:	:	_	24	punct	_	_
40	clonality	clonality	NN	NN	_	41	compound	_	_
41	assays	assay	NNS	NNS	_	43	nsubj	_	_
42	have	have	VBP	VBP	_	43	aux	_	_
43	provided	provide	VBN	VBN	_	24	parataxis	_	_
44	a	a	DT	DT	_	46	det	_	_
45	useful	useful	JJ	JJ	_	46	amod	_	_
46	tool	tool	NN	NN	_	43	dobj	_	_
47	to	to	TO	TO	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	understanding	understanding	NN	NN	_	43	nmod	_	_
50	of	of	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	mechanisms	mechanism	NNS	NNS	_	49	nmod	_	_
53	underlying	underlie	VBG	VBG	_	52	acl	_	_
54	the	the	DT	DT	_	55	det	_	_
55	development	development	NN	NN	_	53	dobj	_	_
56	of	of	IN	IN	_	57	case	_	_
57	neoplasia	neoplasia	NN	NN	_	55	nmod	_	_
58	.	.	.	.	_	24	punct	_	_

1	Recently	recently	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	technique	technique	NN	NN	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	clonal	clonal	JJ	JJ	_	7	amod	_	_
7	analysis	analysis	NN	NN	_	4	nmod	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	devised	devise	VBN	VBN	_	0	root	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	takes	take	VBZ	VBZ	_	10	ccomp	_	_
13	advantage	advantage	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	a	a	DT	DT	_	20	det	_	_
16	highly	highly	RB	RB	_	17	advmod	_	_
17	polymorphic	polymorphic	JJ	JJ	_	20	amod	_	_
18	short	short	JJ	JJ	_	20	amod	_	_
19	tandem	tandem	JJ	JJ	_	20	amod	_	_
20	repeat	repeat	NN	NN	_	13	nmod	_	_
21	within	within	IN	IN	_	30	case	_	_
22	the	the	DT	DT	_	30	det	_	_
23	X-linked	x-linked	JJ	JJ	_	30	amod	_	_
24	human	human	JJ	JJ	_	30	amod	_	_
25	androgen	androgen	NN	NN	_	30	compound	_	_
26	receptor	receptor	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	AR	ar	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	gene	gene	NN	NN	_	20	nmod	_	_
31	,	,	,	,	_	20	punct	_	_
32	resulting	result	VBG	VBG	_	20	acl	_	_
33	in	in	IN	IN	_	36	case	_	_
34	a	a	DT	DT	_	36	det	_	_
35	heterozygosity	heterozygosity	NN	NN	_	36	compound	_	_
36	rate	rate	NN	NN	_	32	nmod	_	_
37	approaching	approach	VBG	VBG	_	36	acl	_	_
38	90	90	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	37	dobj	_	_
40	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	rapid	rapid	JJ	JJ	_	3	amod	_	_
3	expansion	expansion	NN	NN	_	17	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	number	number	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	women	woman	NNS	NNS	_	6	nmod	_	_
9	now	now	RB	RB	_	10	advmod	_	_
10	suitable	suitable	JJ	JJ	_	8	amod	_	_
11	for	for	IN	IN	_	14	case	_	_
12	X	x	NN	NN	_	14	compound	_	_
13	inactivation	inactivation	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	10	nmod	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	however	however	RB	RB	_	17	advmod	_	_
17	given	give	VBN	VBN	_	0	root	_	_
18	rise	rise	NN	NN	_	17	dobj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	new	new	JJ	JJ	_	21	amod	_	_
21	controversies	controversy	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	one	one	CD	CD	_	30	nsubj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	troublesome	troublesome	JJ	JJ	_	23	nmod	_	_
28	being	be	VBG	VBG	_	30	cop	_	_
29	the	the	DT	DT	_	30	det	_	_
30	possibility	possibility	NN	NN	_	17	advcl	_	_
31	of	of	IN	IN	_	33	case	_	_
32	a	a	DT	DT	_	33	det	_	_
33	modification	modification	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	pattern	pattern	NN	NN	_	33	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	X-chromosome	x-chromosome	NN	NN	_	40	compound	_	_
39	inactivation	inactivation	NN	NN	_	40	compound	_	_
40	pattern	pattern	NN	NN	_	36	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	blood	blood	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	of	of	IN	IN	_	46	case	_	_
45	elderly	elderly	JJ	JJ	_	46	amod	_	_
46	women	woman	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	analyze	analyze	VBP	VBP	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	AR	ar	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	6	nmod	_	_
11	a	a	DT	DT	_	12	det	_	_
12	group	group	NN	NN	_	6	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	166	166	CD	CD	_	16	nummod	_	_
15	healthy	healthy	JJ	JJ	_	16	amod	_	_
16	females	female	NNS	NNS	_	12	nmod	_	_
17	aged	aged	JJ	JJ	_	16	amod	_	_
18	between	between	IN	IN	_	19	amod	_	_
19	8	8	CD	CD	_	22	nummod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	94	94	CD	CD	_	19	conj	_	_
22	years	year	NNS	NNS	_	17	nmod:tmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	with	with	IN	IN	_	26	case	_	_
25	no	no	DT	DT	_	26	neg	_	_
26	history	history	NN	NN	_	16	nmod	_	_
27	of	of	IN	IN	_	32	case	_	_
28	genetic	genetic	JJ	JJ	_	32	amod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	neoplastic	neoplastic	JJ	JJ	_	28	conj	_	_
31	familial	familial	JJ	JJ	_	32	amod	_	_
32	disorders	disorder	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	failed	fail	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	find	find	VB	VB	_	2	xcomp	_	_
5	any	any	DT	DT	_	6	det	_	_
6	correlation	correlation	NN	NN	_	4	dobj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	age	age	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	X-chromosome	x-chromosome	NN	NN	_	12	compound	_	_
11	inactivation	inactivation	NN	NN	_	12	compound	_	_
12	pattern	pattern	NN	NN	_	8	conj	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	r	r	NN	NN	_	15	nsubj	_	_
15	=	=	JJ	JJ	_	4	parataxis	_	_
16	0.17	0.17	CD	CD	_	15	dobj	_	_
17	)	)	-RRB-	-RRB-	_	15	punct	_	_
18	,	,	,	,	_	2	punct	_	_
19	even	even	RB	RB	_	20	advmod	_	_
20	subdividing	subdivide	VBG	VBG	_	2	ccomp	_	_
21	the	the	DT	DT	_	22	det	_	_
22	subjects	subject	NNS	NNS	_	20	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	different	different	JJ	JJ	_	26	amod	_	_
25	age	age	NN	NN	_	26	compound	_	_
26	groups	group	NNS	NNS	_	20	nmod	_	_
27	according	accord	VBG	VBG	_	30	case	_	_
28	to	to	TO	TO	_	27	mwe	_	_
29	the	the	DT	DT	_	30	det	_	_
30	criteria	criterion	NNS	NNS	_	20	nmod	_	_
31	used	use	VBN	VBN	_	30	acl	_	_
32	by	by	IN	IN	_	34	case	_	_
33	other	other	JJ	JJ	_	34	amod	_	_
34	researchers	researcher	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	2	punct	_	_
36	and	and	CC	CC	_	2	cc	_	_
37	therefore	therefore	RB	RB	_	2	advmod	_	_
38	reaffirm	reaffirm	VBP	VBP	_	2	dep	_	_
39	that	that	IN	IN	_	61	mark	_	_
40	,	,	,	,	_	61	punct	_	_
41	when	when	WRB	WRB	_	42	advmod	_	_
42	tested	test	VBN	VBN	_	61	advcl	_	_
43	for	for	IN	IN	_	42	nmod	_	_
44	with	with	IN	IN	_	48	case	_	_
45	well-standardized	well-standardized	JJ	JJ	_	48	amod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	accurate	accurate	JJ	JJ	_	45	conj	_	_
48	criteria	criterion	NNS	NNS	_	42	nmod	_	_
49	,	,	,	,	_	61	punct	_	_
50	extremely	extremely	RB	RB	_	51	advmod	_	_
51	unbalanced	unbalanced	JJ	JJ	_	52	amod	_	_
52	inactivation	inactivation	NN	NN	_	61	nsubj	_	_
53	of	of	IN	IN	_	56	case	_	_
54	the	the	DT	DT	_	56	det	_	_
55	X	x	NN	NN	_	56	compound	_	_
56	chromosome	chromosome	NN	NN	_	52	nmod	_	_
57	is	be	VBZ	VBZ	_	61	cop	_	_
58	a	a	DT	DT	_	61	det	_	_
59	truly	truly	RB	RB	_	60	advmod	_	_
60	uncommon	uncommon	JJ	JJ	_	61	amod	_	_
61	phenomenon	phenomenon	NN	NN	_	38	ccomp	_	_
62	in	in	IN	IN	_	64	case	_	_
63	normal	normal	JJ	JJ	_	64	amod	_	_
64	women	woman	NNS	NNS	_	61	nmod	_	_
65	.	.	.	.	_	2	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1998	1998	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	elk-1	elk-1	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Potential	potential	JJ	JJ	_	2	amod	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	a	a	DT	DT	_	7	det	_	_
5	downstream	downstream	JJ	JJ	_	7	amod	_	_
6	intronic	intronic	JJ	JJ	_	7	amod	_	_
7	sequence	sequence	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	11	case	_	_
9	elk-1	elk-1	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	2	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	characterize	characterize	VB	VB	_	9	advcl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	elk-1	elk-1	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	mapped	map	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	13	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
12	start	start	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	9	dobj	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	isolated	isolate	VBD	VBD	_	9	conj	_	_
16	elk-1-specific	elk-1-specific	JJ	JJ	_	19	amod	_	_
17	genomic	genomic	JJ	JJ	_	19	amod	_	_
18	phage	phage	NN	NN	_	19	compound	_	_
19	clones	clone	NNS	NNS	_	15	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	contained	contain	VBD	VBD	_	19	acl:relcl	_	_
22	extensive	extensive	JJ	JJ	_	26	amod	_	_
23	upstream	upstream	JJ	JJ	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	downstream	downstream	JJ	JJ	_	23	conj	_	_
26	sequences	sequence	NNS	NNS	_	21	dobj	_	_
27	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	TATA-like	tata-like	JJ	JJ	_	3	amod	_	_
3	motif	motif	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	identified	identify	VBN	VBN	_	0	root	_	_
6	immediately	immediately	RB	RB	_	7	advmod	_	_
7	upstream	upstream	RB	RB	_	5	advmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
11	start	start	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analyses	analysis	NNS	NNS	_	30	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	DNA	dna	NN	NN	_	5	compound	_	_
5	fragments	fragment	NNS	NNS	_	2	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	TATA	tata	NN	NN	_	9	compound	_	_
9	element	element	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	2	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	identification	identification	NN	NN	_	2	conj	_	_
13	of	of	IN	IN	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	DNase	dnase	NN	NN	_	18	compound	_	_
16	I-hypersensitive	i-hypersensitive	JJ	JJ	_	18	amod	_	_
17	chromatin	chromatin	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HS	hs	NN	NN	_	18	appos	_	_
21	1	1	CD	CD	_	20	nummod	_	_
22	)	)	-RRB-	-RRB-	_	20	punct	_	_
23	in	in	IN	IN	_	25	case	_	_
24	close	close	JJ	JJ	_	25	amod	_	_
25	proximity	proximity	NN	NN	_	18	nmod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	TATA	tata	NN	NN	_	29	compound	_	_
29	box	box	NN	NN	_	25	nmod	_	_
30	suggest	suggest	VBP	VBP	_	0	root	_	_
31	that	that	IN	IN	_	37	mark	_	_
32	the	the	DT	DT	_	35	det	_	_
33	identified	identify	VBN	VBN	_	35	amod	_	_
34	TATA	tata	NN	NN	_	35	compound	_	_
35	motif	motif	NN	NN	_	37	nsubj	_	_
36	is	be	VBZ	VBZ	_	37	cop	_	_
37	important	important	JJ	JJ	_	30	ccomp	_	_
38	for	for	IN	IN	_	40	case	_	_
39	elk-1	elk-1	NN	NN	_	40	compound	_	_
40	transcription	transcription	NN	NN	_	37	nmod	_	_
41	in	in	FW	FW	_	42	compound	_	_
42	vivo	vivo	FW	FW	_	40	advmod	_	_
43	.	.	.	.	_	30	punct	_	_

1	Sequences	sequence	NNS	NNS	_	10	nsubjpass	_	_
2	upstream	upstream	JJ	JJ	_	3	advmod	_	_
3	and	and	CC	CC	_	1	advmod	_	_
4	downstream	downstream	JJ	JJ	_	3	advmod	_	_
5	from	from	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TATA	tata	NN	NN	_	8	compound	_	_
8	box	box	NN	NN	_	3	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	contribute	contribute	VB	VB	_	10	xcomp	_	_
13	to	to	TO	TO	_	16	case	_	_
14	elk-1	elk-1	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	second	second	JJ	JJ	_	4	amod	_	_
3	hypersensitive	hypersensitive	JJ	JJ	_	4	amod	_	_
4	site	site	NN	NN	_	10	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HS	hs	NN	NN	_	4	appos	_	_
7	2	2	CD	CD	_	6	nummod	_	_
8	)	)	-RRB-	-RRB-	_	6	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	within	within	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	first	first	JJ	JJ	_	14	amod	_	_
14	intron	intron	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	pre-monocytic	pre-monocytic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	express	express	VBP	VBP	_	17	acl:relcl	_	_
21	Elk-1	elk-1	NN	NN	_	20	dobj	_	_
22	only	only	RB	RB	_	23	advmod	_	_
23	when	when	WRB	WRB	_	24	advmod	_	_
24	differentiating	differentiate	VBG	VBG	_	20	advcl	_	_
25	to	to	TO	TO	_	26	case	_	_
26	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	variety	variety	NN	NN	_	20	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	other	other	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	types	type	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	display	display	VBP	VBP	_	7	acl:relcl	_	_
11	a	a	DT	DT	_	14	det	_	_
12	constitutive	constitutive	JJ	JJ	_	14	amod	_	_
13	Elk-1	elk-1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	dobj	_	_
15	,	,	,	,	_	20	punct	_	_
16	HS	hs	NN	NN	_	20	nsubj	_	_
17	2	2	CD	CD	_	16	nummod	_	_
18	did	do	VBD	VBD	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	exist	exist	VB	VB	_	0	root	_	_
21	,	,	,	,	_	20	punct	_	_
22	suggesting	suggest	VBG	VBG	_	20	xcomp	_	_
23	that	that	IN	IN	_	29	mark	_	_
24	inducibility	inducibility	NN	NN	_	29	nsubjpass	_	_
25	of	of	IN	IN	_	27	case	_	_
26	elk-1	elk-1	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	associated	associate	VBN	VBN	_	22	ccomp	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	presence	presence	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	HS	hs	NN	NN	_	32	nmod	_	_
35	2	2	CD	CD	_	34	nummod	_	_
36	.	.	.	.	_	20	punct	_	_

1	Egr-1	egr-1	NN	NN	_	8	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	6	det	_	_
4	serum	serum	NN	NN	_	6	compound	_	_
5	response	response	NN	NN	_	6	compound	_	_
6	factor	factor	NN	NN	_	1	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	interact	interact	VB	VB	_	8	xcomp	_	_
11	specifically	specifically	RB	RB	_	15	advmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	intronic	intronic	JJ	JJ	_	15	amod	_	_
15	sequence	sequence	NN	NN	_	10	nmod	_	_
16	at	at	IN	IN	_	17	case	_	_
17	+265	+265	CD	CD	_	10	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	+448	+448	CD	CD	_	17	conj	_	_
20	,	,	,	,	_	10	punct	_	_
21	respectively	respectively	RB	RB	_	10	advmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Because	because	IN	IN	_	8	mark	_	_
2	Egr-1	egr-1	NN	NN	_	3	compound	_	_
3	mRNA	mrna	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	19	advcl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	increase	increase	VB	VB	_	8	xcomp	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	before	before	IN	IN	_	13	case	_	_
13	induction	induction	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	elk-1	elk-1	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	propose	propose	VBP	VBP	_	0	root	_	_
20	that	that	IN	IN	_	23	mark	_	_
21	Egr-1	egr-1	NN	NN	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	important	important	JJ	JJ	_	19	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regulation	regulation	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	elk-1	elk-1	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	differentiating	differentiate	VBG	VBG	_	32	amod	_	_
32	monocytes	monocyte	NNS	NNS	_	26	nmod	_	_
33	.	.	.	.	_	19	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	suppression	suppression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Stat1	stat1	NN	NN	_	5	compound	_	_
5	function	function	NN	NN	_	2	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	adenoviral	adenoviral	JJ	JJ	_	8	amod	_	_
8	infection	infection	NN	NN	_	2	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	action	action	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	adenoviral	adenoviral	JJ	JJ	_	6	amod	_	_
5	E1A	e1a	NN	NN	_	6	compound	_	_
6	oncoprotein	oncoprotein	NN	NN	_	2	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	host	host	NN	NN	_	10	compound	_	_
9	immune-response	immune-response	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	2	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	attributed	attribute	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	case	_	_
15	interaction	interaction	NN	NN	_	13	nmod	_	_
16	with	with	IN	IN	_	19	case	_	_
17	p300/CBP-type	p300/cbp-type	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	coactivators	coactivator	NNS	NNS	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	competition	competition	NN	NN	_	15	nmod	_	_
22	with	with	IN	IN	_	25	case	_	_
23	endogenous	endogenous	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	21	nmod	_	_
26	such	such	JJ	JJ	_	29	case	_	_
27	as	as	IN	IN	_	26	mwe	_	_
28	signal	signal	NN	NN	_	29	compound	_	_
29	transducer	transducer	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	activator	activator	NN	NN	_	29	conj	_	_
32	of	of	IN	IN	_	37	case	_	_
33	transcription	transcription	NN	NN	_	37	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	STAT	stat	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	proteins	protein	NNS	NNS	_	29	nmod	_	_
38	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	mutant	mutant	JJ	JJ	_	7	amod	_	_
7	forms	form	NNS	NNS	_	17	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	E1A	e1a	NN	NN	_	7	nmod	_	_
10	that	that	WDT	WDT	_	13	nsubj	_	_
11	no	no	RB	RB	_	12	neg	_	_
12	longer	longer	RBR	RBR	_	13	advmod	_	_
13	bind	bind	VBP	VBP	_	7	acl:relcl	_	_
14	p300/CBP	p300/cbp	NN	NN	_	13	dobj	_	_
15	can	can	MD	MD	_	17	aux	_	_
16	still	still	RB	RB	_	17	advmod	_	_
17	interact	interact	VB	VB	_	4	ccomp	_	_
18	directly	directly	RB	RB	_	17	advmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	Stat1	stat1	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	17	punct	_	_
22	via	via	IN	IN	_	28	case	_	_
23	E1A	e1a	NN	NN	_	24	nmod:npmod	_	_
24	N-terminal	n-terminal	JJ	JJ	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	Stat1	stat1	NN	NN	_	27	nmod:npmod	_	_
27	C-terminal	c-terminal	JJ	JJ	_	24	conj	_	_
28	residues	residue	NNS	NNS	_	17	nmod	_	_
29	)	)	-RRB-	-RRB-	_	17	punct	_	_
30	and	and	CC	CC	_	17	cc	_	_
31	block	block	VB	VB	_	17	conj	_	_
32	IFNgamma-driven	ifngamma-driven	JJ	JJ	_	36	amod	_	_
33	,	,	,	,	_	32	punct	_	_
34	Stat1-dependent	stat1-dependent	JJ	JJ	_	32	dep	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	31	dobj	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	consequent	consequent	JJ	JJ	_	39	amod	_	_
39	function	function	NN	NN	_	36	conj	_	_
40	during	during	IN	IN	_	42	case	_	_
41	early-phase	early-phase	JJ	JJ	_	42	amod	_	_
42	infection	infection	NN	NN	_	39	nmod	_	_
43	in	in	IN	IN	_	47	case	_	_
44	the	the	DT	DT	_	47	det	_	_
45	natural	natural	JJ	JJ	_	47	amod	_	_
46	host	host	NN	NN	_	47	compound	_	_
47	cell	cell	NN	NN	_	42	nmod	_	_
48	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	9	det	_	_
5	distinct	distinct	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	more	more	RBR	RBR	_	8	advmod	_	_
8	specific	specific	JJ	JJ	_	5	conj	_	_
9	mechanism	mechanism	NN	NN	_	3	dobj	_	_
10	for	for	IN	IN	_	13	case	_	_
11	E1A-mediated	e1a-mediated	JJ	JJ	_	13	amod	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	suppression	suppression	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	an	a	DT	DT	_	17	det	_	_
16	alternative	alternative	JJ	JJ	_	17	amod	_	_
17	model	model	NN	NN	_	9	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	IFNgamma-driven	ifngamma-driven	JJ	JJ	_	21	amod	_	_
20	enhanceosome	enhanceosome	NN	NN	_	21	compound	_	_
21	formation	formation	NN	NN	_	17	nmod	_	_
22	that	that	WDT	WDT	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	allow	allow	VB	VB	_	17	acl:relcl	_	_
25	for	for	IN	IN	_	35	mark	_	_
26	other	other	JJ	JJ	_	27	amod	_	_
27	adaptors	adaptor	NNS	NNS	_	35	nsubj	_	_
28	(	(	-LRB-	-LRB-	_	27	punct	_	_
29	in	in	IN	IN	_	27	cc	_	_
30	addition	addition	NN	NN	_	29	dep	_	_
31	to	to	TO	TO	_	29	dep	_	_
32	p300/CBP	p300/cbp	NN	NN	_	27	conj	_	_
33	)	)	-RRB-	-RRB-	_	27	punct	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	link	link	VB	VB	_	24	advcl	_	_
36	Stat1	stat1	NN	NN	_	35	dobj	_	_
37	to	to	TO	TO	_	41	case	_	_
38	the	the	DT	DT	_	41	det	_	_
39	basal	basal	JJ	JJ	_	41	amod	_	_
40	transcription	transcription	NN	NN	_	41	compound	_	_
41	complex	complex	NN	NN	_	35	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	8	amod	_	_
2	T-cell	t-cell	NN	NN	_	8	compound	_	_
3	leukemia	leukemia	NN	NN	_	8	compound	_	_
4	virus	virus	NN	NN	_	8	compound	_	_
5	type	type	NN	NN	_	8	compound	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	tax	tax	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	9	nsubj	_	_
9	abrogates	abrogate	VBZ	VBZ	_	0	root	_	_
10	interleukin-2	interleukin-2	NN	NN	_	11	compound	_	_
11	dependence	dependence	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	a	a	DT	DT	_	16	det	_	_
14	mouse	mouse	NN	NN	_	16	compound	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	line	line	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	13	nsubj	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-1	htlv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	the	the	DT	DT	_	13	det	_	_
12	etiologic	etiologic	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	17	case	_	_
15	adult	adult	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Tax	tax	NN	NN	_	8	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	viral	viral	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	thought	think	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	crucial	crucial	JJ	JJ	_	8	xcomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	development	development	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	disease	disease	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	since	since	IN	IN	_	21	mark	_	_
20	it	it	PRP	PRP	_	21	nsubj	_	_
21	transforms	transform	VBZ	VBZ	_	8	advcl	_	_
22	healthy	healthy	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	dobj	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vitro	vitro	FW	FW	_	21	advmod	_	_
27	and	and	CC	CC	_	21	cc	_	_
28	induces	induce	VBZ	VBZ	_	21	conj	_	_
29	tumors	tumor	NNS	NNS	_	28	dobj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	transgenic	transgenic	JJ	JJ	_	32	amod	_	_
32	animals	animal	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Tax	tax	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	growth	growth	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	20	case	_	_
12	the	the	DT	DT	_	20	det	_	_
13	interleukin-2	interleukin-2	NN	NN	_	20	compound	_	_
14	(	(	-LRB-	-LRB-	_	20	punct	_	_
15	IL-2	il-2	NN	NN	_	20	compound	_	_
16	)	)	-RRB-	-RRB-	_	20	punct	_	_
17	-dependent	-dependent	JJ	JJ	_	20	amod	_	_
18	T-cell	t-cell	NN	NN	_	20	compound	_	_
19	line	line	NN	NN	_	20	compound	_	_
20	CTLL-2	ctll-2	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Stable	stable	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Tax	tax	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	CTLL-2	ctll-2	NN	NN	_	2	nmod	_	_
7	transformed	transform	VBD	VBD	_	0	root	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	7	dobj	_	_
10	from	from	IN	IN	_	13	mark	_	_
11	being	be	VBG	VBG	_	13	cop	_	_
12	IL-2	il-2	NN	NN	_	13	nmod:npmod	_	_
13	dependent	dependent	JJ	JJ	_	7	advcl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	IL-2	il-2	NN	NN	_	16	nmod:npmod	_	_
16	independent	independent	JJ	JJ	_	7	advcl	_	_
17	.	.	.	.	_	7	punct	_	_

1	Tax	tax	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	transcription	transcription	NN	NN	_	2	dobj	_	_
4	through	through	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	11	det	_	_
8	cyclic	cyclic	JJ	JJ	_	11	amod	_	_
9	AMP-responsive	amp-responsive	JJ	JJ	_	11	amod	_	_
10	element-like	element-like	JJ	JJ	_	11	amod	_	_
11	sequence	sequence	NN	NN	_	5	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HTLV-1	htlv-1	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	Tax	tax	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	2	nmod	_	_
6	segregating	segregate	VBG	VBG	_	5	acl	_	_
7	these	these	DT	DT	_	9	det	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	pathways	pathway	NNS	NNS	_	6	dobj	_	_
10	suggested	suggest	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	16	nsubj	_	_
15	was	be	VBD	VBD	_	16	cop	_	_
16	essential	essential	JJ	JJ	_	10	ccomp	_	_
17	for	for	IN	IN	_	19	case	_	_
18	IL-2-independent	il-2-independent	JJ	JJ	_	19	amod	_	_
19	growth	growth	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	CTLL-2	ctll-2	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	while	while	IN	IN	_	28	mark	_	_
24	the	the	DT	DT	_	26	det	_	_
25	CRE	cre	NN	NN	_	26	compound	_	_
26	pathway	pathway	NN	NN	_	28	nsubj	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	unnecessary	unnecessary	JJ	JJ	_	16	advcl	_	_
29	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	both	both	DT	DT	_	4	det	_	_
4	pathways	pathway	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	necessary	necessary	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	another	another	DT	DT	_	10	det	_	_
9	transformation-related	transformation-related	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	colony	colony	NN	NN	_	13	compound	_	_
13	formation	formation	NN	NN	_	10	dep	_	_
14	in	in	IN	IN	_	16	case	_	_
15	soft	soft	JJ	JJ	_	16	amod	_	_
16	agar	agar	NN	NN	_	13	nmod	_	_
17	)	)	-RRB-	-RRB-	_	13	punct	_	_
18	of	of	IN	IN	_	19	case	_	_
19	CTLL-2/Tax	ctll-2/tax	NN	NN	_	10	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Tax	tax	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	3	ccomp	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	activities	activity	NNS	NNS	_	6	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	suggest	suggest	VBP	VBP	_	3	conj	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	Tax	tax	NN	NN	_	20	nsubj	_	_
20	plays	play	VBZ	VBZ	_	17	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	crucial	crucial	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	IL-2-independent	il-2-independent	JJ	JJ	_	27	amod	_	_
26	T-cell	t-cell	NN	NN	_	27	compound	_	_
27	transformation	transformation	NN	NN	_	20	nmod	_	_
28	induced	induce	VBN	VBN	_	27	acl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	HTLV-1	htlv-1	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	27	punct	_	_
32	in	in	IN	IN	_	27	cc	_	_
33	addition	addition	NN	NN	_	32	dep	_	_
34	to	to	TO	TO	_	32	dep	_	_
35	its	its	PRP$	PRP$	_	39	nmod:poss	_	_
36	well-known	well-known	JJ	JJ	_	39	amod	_	_
37	IL-2-dependent	il-2-dependent	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	transformation	transformation	NN	NN	_	27	conj	_	_
40	.	.	.	.	_	3	punct	_	_

1	Mildly	mildly	RB	RB	_	2	advmod	_	_
2	oxidized	oxidize	VBN	VBN	_	4	amod	_	_
3	low-density	low-density	JJ	JJ	_	4	amod	_	_
4	lipoproteins	lipoprotein	NNS	NNS	_	5	nsubj	_	_
5	decrease	decrease	VBP	VBP	_	0	root	_	_
6	early	early	JJ	JJ	_	7	amod	_	_
7	production	production	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	interleukin	interleukin	NN	NN	_	7	nmod	_	_
10	2	2	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	kappaB	kappab	NN	NN	_	9	conj	_	_
15	binding	bind	VBG	VBG	_	14	amod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	DNA	dna	NN	NN	_	9	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	activated	activate	VBN	VBN	_	20	amod	_	_
20	T-lymphocytes	t-lymphocyte	NNS	NNS	_	5	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Activated	activate	VBN	VBN	_	2	amod	_	_
2	T-lymphocytes	t-lymphocyte	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	early	early	RB	RB	_	4	advmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	atherosclerosis	atherosclerosis	NN	NN	_	8	compound	_	_
8	lesions	lesion	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	but	but	CC	CC	_	4	cc	_	_
11	little	little	JJ	JJ	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	known	know	VBN	VBN	_	4	conj	_	_
14	about	about	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	role	role	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Oxidized	oxidize	VBN	VBN	_	3	amod	_	_
2	low-density	low-density	JJ	JJ	_	3	amod	_	_
3	lipoproteins	lipoprotein	NNS	NNS	_	8	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	oxLDLs	oxldl	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	considered	consider	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	involved	involve	VBN	VBN	_	8	xcomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pathogenesis	pathogenesis	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	lesions	lesion	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	we	we	PRP	PRP	_	23	nsubj	_	_
21	have	have	VBP	VBP	_	23	aux	_	_
22	previously	previously	RB	RB	_	23	advmod	_	_
23	demonstrated	demonstrate	VBN	VBN	_	8	conj	_	_
24	that	that	IN	IN	_	26	mark	_	_
25	oxLDLs	oxldl	NNS	NNS	_	26	nsubj	_	_
26	inhibit	inhibit	VBP	VBP	_	23	ccomp	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	only	only	RB	RB	_	34	cc:preconj	_	_
29	interleukin	interleukin	NN	NN	_	34	compound	_	_
30	(	(	-LRB-	-LRB-	_	34	punct	_	_
31	IL	il	NN	NN	_	34	compound	_	_
32	)	)	-RRB-	-RRB-	_	34	punct	_	_
33	-2-receptor	-2-receptor	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	26	dobj	_	_
35	on	on	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	surface	surface	NN	NN	_	34	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	in	in	FW	FW	_	40	dep	_	_
40	vitro-activated	vitro-activated	JJ	JJ	_	41	amod	_	_
41	T-lymphocytes	t-lymphocyte	NNS	NNS	_	37	nmod	_	_
42	but	but	CC	CC	_	34	cc	_	_
43	also	also	RB	RB	_	45	advmod	_	_
44	their	they	PRP$	PRP$	_	45	nmod:poss	_	_
45	proliferation	proliferation	NN	NN	_	34	conj	_	_
46	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	oxLDLs	oxldl	NNS	NNS	_	6	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	blast	blast	NN	NN	_	11	compound	_	_
11	differentiation	differentiation	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	on	on	IN	IN	_	15	case	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	synthesis	synthesis	NN	NN	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	on	on	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	11	conj	_	_
20	of	of	IN	IN	_	28	case	_	_
21	the	the	DT	DT	_	28	det	_	_
22	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
23	factor	factor	NN	NN	_	24	compound	_	_
24	kappaB	kappab	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	system	system	NN	NN	_	19	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	activated	activate	VBN	VBN	_	31	amod	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Mildly	mildly	RB	RB	_	2	advmod	_	_
2	oxLDLs	oxldl	NNS	NNS	_	9	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	50	50	CD	CD	_	7	nummod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	100	100	CD	CD	_	4	conj	_	_
7	microgram/ml	microgram/ml	NN	NN	_	2	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	decreased	decrease	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	number	number	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	lymphoblasts	lymphoblast	NNS	NNS	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	level	level	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	IL-2	il-2	NN	NN	_	19	compound	_	_
19	concentration	concentration	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	culture	culture	NN	NN	_	23	compound	_	_
23	supernatants	supernatant	NNS	NNS	_	11	nmod	_	_
24	after	after	IN	IN	_	25	case	_	_
25	activation	activation	NN	NN	_	9	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	25	nmod	_	_
28	by	by	IN	IN	_	29	case	_	_
29	phytohaemagglutinin	phytohaemagglutinin	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	PMA+ionomycin	pma+ionomycin	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	CD3(+)	cd3(+)	JJ	JJ	_	12	amod	_	_
11	T-lymphocyte	t-lymphocyte	NN	NN	_	12	compound	_	_
12	cytoplasm	cytoplasm	NN	NN	_	7	nmod	_	_
13	as	as	RB	RB	_	16	advmod	_	_
14	early	early	RB	RB	_	16	advmod	_	_
15	as	as	IN	IN	_	16	advmod	_	_
16	4	4	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	7	nmod	_	_
18	after	after	IN	IN	_	17	case	_	_
19	activation	activation	NN	NN	_	17	dep	_	_
20	by	by	IN	IN	_	21	case	_	_
21	PMA+ionomycin	pma+ionomycin	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	oxLDLs	oxldl	NNS	NNS	_	8	nsubj	_	_
8	led	lead	VBD	VBD	_	5	ccomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	decrease	decrease	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	activation-induced	activation-induced	JJ	JJ	_	17	amod	_	_
14	p65/p50	p65/p50	NN	NN	_	17	compound	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
16	heterodimer	heterodimer	NN	NN	_	17	compound	_	_
17	binding	binding	NN	NN	_	11	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	DNA	dna	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	whereas	whereas	IN	IN	_	33	mark	_	_
22	the	the	DT	DT	_	23	det	_	_
23	presence	presence	NN	NN	_	33	nsubj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	constitutive	constitutive	JJ	JJ	_	28	amod	_	_
27	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
28	form	form	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	p50	p50	NN	NN	_	31	compound	_	_
31	dimer	dimer	NN	NN	_	28	nmod	_	_
32	was	be	VBD	VBD	_	33	cop	_	_
33	unchanged	unchanged	JJ	JJ	_	8	advcl	_	_
34	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	correlated	correlate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	unchanged	unchanged	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	active	active	JJ	JJ	_	11	amod	_	_
11	form	form	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	cytosolic	cytosolic	JJ	JJ	_	17	amod	_	_
15	inhibitor	inhibitor	NN	NN	_	17	compound	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	IkappaB-alpha	ikappab-alpha	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	observations	observation	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VB	VB	_	0	root	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immunosuppressive	immunosuppressive	JJ	JJ	_	10	amod	_	_
10	effect	effect	NN	NN	_	14	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	oxLDLs	oxldl	NNS	NNS	_	10	nmod	_	_
13	might	might	MD	MD	_	14	aux	_	_
14	operate	operate	VB	VB	_	6	ccomp	_	_
15	via	via	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	dysregulation	dysregulation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	T-lymphocyte	t-lymphocyte	NN	NN	_	22	compound	_	_
21	activation	activation	NN	NN	_	22	compound	_	_
22	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	Binding	binding	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HMG-I(Y)	hmg-i(y)	NN	NN	_	1	nmod	_	_
4	elicits	elicit	VBZ	VBZ	_	0	root	_	_
5	structural	structural	JJ	JJ	_	6	amod	_	_
6	changes	change	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	silencer	silencer	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	beta-globin	beta-globin	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Proteins	protein	NNS	NNS	_	12	nsubj	_	_
2	involved	involve	VBN	VBN	_	1	acl	_	_
3	in	in	IN	IN	_	4	case	_	_
4	repression	repression	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	beta-globin	beta-globin	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	may	may	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	cop	_	_
12	useful	useful	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	sickle	sickle	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	anemia	anemia	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	in	in	IN	IN	_	24	case	_	_
22	conjunction	conjunction	NN	NN	_	24	dep	_	_
23	with	with	IN	IN	_	24	case	_	_
24	therapy	therapy	NN	NN	_	12	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	reactivate	reactivate	VB	VB	_	24	acl	_	_
27	fetal	fetal	JJ	JJ	_	29	amod	_	_
28	globin	globin	NN	NN	_	29	compound	_	_
29	genes	gene	NNS	NNS	_	26	dobj	_	_
30	.	.	.	.	_	12	punct	_	_

1	If	if	IN	IN	_	3	mark	_	_
2	there	there	EX	EX	_	3	expl	_	_
3	is	be	VBZ	VBZ	_	17	advcl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	reciprocal	reciprocal	JJ	JJ	_	6	amod	_	_
6	elevation	elevation	NN	NN	_	3	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	gamma-globin	gamma-globin	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	repression	repression	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	17	punct	_	_
13	this	this	DT	DT	_	14	det	_	_
14	approach	approach	NN	NN	_	17	nsubj	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	useful	useful	JJ	JJ	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	additional	additional	JJ	JJ	_	20	amod	_	_
20	hemoglobinopathies	hemoglobinopathy	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	repression	repression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	beta-globin	beta-globin	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	appears	appear	VBZ	VBZ	_	3	ccomp	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	10	xcomp	_	_
14	through	through	IN	IN	_	17	case	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	DNA	dna	NN	NN	_	17	compound	_	_
17	sequences	sequence	NNS	NNS	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	silencers	silencer	NNS	NNS	_	17	appos	_	_
20	I	i	CD	CD	_	19	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	II	ii	CD	CD	_	20	conj	_	_
23	,	,	,	,	_	3	punct	_	_
24	and	and	CC	CC	_	3	cc	_	_
25	identified	identify	VBD	VBD	_	3	conj	_	_
26	a	a	DT	DT	_	27	det	_	_
27	protein	protein	NN	NN	_	25	dobj	_	_
28	termed	term	VBN	VBN	_	27	acl	_	_
29	BP1	bp1	NN	NN	_	28	xcomp	_	_
30	which	which	WDT	WDT	_	31	nsubj	_	_
31	binds	bind	VBZ	VBZ	_	27	acl:relcl	_	_
32	to	to	TO	TO	_	35	case	_	_
33	both	both	DT	DT	_	35	det	_	_
34	silencer	silencer	JJ	JJ	_	35	amod	_	_
35	sequences	sequence	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	cloned	clone	VBD	VBD	_	0	root	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	cDNAs	cdna	NNS	NNS	_	6	dobj	_	_
9	encoding	encoding	NN	NN	_	8	dep	_	_
10	proteins	protein	NNS	NNS	_	9	dobj	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	bind	bind	VBP	VBP	_	10	acl:relcl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	oligonucleotide	oligonucleotide	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	silencer	silencer	NN	NN	_	15	nmod	_	_
18	I	i	CD	CD	_	17	nummod	_	_
19	containing	contain	VBG	VBG	_	17	acl	_	_
20	a	a	DT	DT	_	23	det	_	_
21	BP1	bp1	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cDNAs	cdna	NNS	NNS	_	3	nsubj	_	_
3	correspond	correspond	VBP	VBP	_	0	root	_	_
4	to	to	TO	TO	_	5	case	_	_
5	HMG-I	hmg-i	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	HMG-Y	hmg-y	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	isoforms	isoform	NNS	NNS	_	5	appos	_	_
10	regarded	regard	VBN	VBN	_	9	dep	_	_
11	as	as	IN	IN	_	13	case	_	_
12	architectural	architectural	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	binding	binding	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HMG-I(Y)	hmg-i(y)	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	oligonucleotide	oligonucleotide	NN	NN	_	4	nmod	_	_
10	causes	cause	VBZ	VBZ	_	2	ccomp	_	_
11	bending/flexure	bending/flexure	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	DNA	dna	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	HMG-I(Y)	hmg-i(y)	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	binds	bind	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	second	second	JJ	JJ	_	7	amod	_	_
7	oligonucleotide	oligonucleotide	NN	NN	_	3	nmod	_	_
8	containing	contain	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	BP1	bp1	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	8	dobj	_	_
13	located	located	JJ	JJ	_	12	amod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	negative	negative	JJ	JJ	_	18	amod	_	_
17	control	control	NN	NN	_	18	compound	_	_
18	region	region	NN	NN	_	13	nmod	_	_
19	upstream	upstream	JJ	JJ	_	18	advmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	delta-globin	delta-globin	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	suggesting	suggest	VBG	VBG	_	3	xcomp	_	_
26	a	a	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	for	for	IN	IN	_	29	case	_	_
29	HMG-I(Y)	hmg-i(y)	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	repression	repression	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	adult	adult	JJ	JJ	_	35	amod	_	_
34	globin	globin	NN	NN	_	35	compound	_	_
35	genes	gene	NNS	NNS	_	31	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	HMG-I(Y)	hmg-i(y)	NN	NN	_	8	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	8	auxpass	_	_
7	ubiquitously	ubiquitously	RB	RB	_	8	advmod	_	_
8	expressed	express	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	tissues	tissue	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	15	nsubj	_	_
13	do	do	VBP	VBP	_	15	aux	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	express	express	VB	VB	_	11	acl:relcl	_	_
16	beta-globin	beta-globin	NN	NN	_	15	dobj	_	_
17	,	,	,	,	_	8	punct	_	_
18	being	be	VBG	VBG	_	19	cop	_	_
19	present	present	JJ	JJ	_	8	xcomp	_	_
20	in	in	IN	IN	_	24	case	_	_
21	48	48	CD	CD	_	23	compound	_	_
22	of	of	IN	IN	_	23	advmod	_	_
23	50	50	CD	CD	_	24	nummod	_	_
24	tissues	tissue	NNS	NNS	_	19	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	six	six	CD	CD	_	29	nummod	_	_
27	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	24	conj	_	_
30	examined	examine	VBN	VBN	_	24	acl	_	_
31	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	HMG-I(Y)	hmg-i(y)	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
7	during	during	IN	IN	_	8	case	_	_
8	differentiation	differentiation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	primary	primary	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	present	present	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	HMG-I(Y)	hmg-i(y)	NN	NN	_	8	nsubj	_	_
8	alters	alter	VBZ	VBZ	_	4	acl:relcl	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	conformation	conformation	NN	NN	_	8	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	allow	allow	VB	VB	_	8	advcl	_	_
13	binding	binding	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	repressor	repressor	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	26	nmod	_	_
21	the	the	DT	DT	_	23	det	_	_
22	relative	relative	JJ	JJ	_	23	amod	_	_
23	amount	amount	NN	NN	_	26	nsubj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	HMG-I(Y)	hmg-i(y)	NN	NN	_	23	nmod	_	_
26	helps	help	VBZ	VBZ	_	8	conj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	determine	determine	VB	VB	_	26	xcomp	_	_
29	the	the	DT	DT	_	31	det	_	_
30	repressive	repressive	JJ	JJ	_	31	amod	_	_
31	state	state	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	beta-globin	beta-globin	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	pro-myelocytic	pro-myelocytic	JJ	JJ	_	6	amod	_	_
5	leukaemia	leukaemia	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	type	type	NN	NN	_	1	nmod	_	_
9	I	i	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	interferons	interferon	NNS	NNS	_	8	conj	_	_
14	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	physiological	physiological	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	12	case	_	_
5	the	the	DT	DT	_	12	det	_	_
6	pro-myelocytic	pro-myelocytic	JJ	JJ	_	12	amod	_	_
7	leukaemia	leukaemia	NN	NN	_	12	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	PML	pml	NN	NN	_	12	compound	_	_
10	)	)	-RRB-	-RRB-	_	12	punct	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	product	product	NN	NN	_	3	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	poorly	poorly	RB	RB	_	15	advmod	_	_
15	defined	define	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	other	other	JJ	JJ	_	3	amod	_	_
3	functions	function	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	PML	pml	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	haematopoietic	haematopoietic	JJ	JJ	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	in	in	IN	IN	_	13	case	_	_
13	control	control	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	growth	growth	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	tumorigenesis	tumorigenesis	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	PML	pml	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	interferons	interferon	NNS	NNS	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IFNs	ifn	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	IL-1	il-1	NN	NN	_	10	conj	_	_
16	in	in	IN	IN	_	20	case	_	_
17	various	various	JJ	JJ	_	20	amod	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	haematopoietic	haematopoietic	JJ	JJ	_	20	amod	_	_
20	lines	line	NNS	NNS	_	8	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	U937	u937	NN	NN	_	20	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	THP1	thp1	NN	NN	_	22	appos	_	_
25	,	,	,	,	_	22	punct	_	_
26	HL60	hl60	NN	NN	_	22	appos	_	_
27	,	,	,	,	_	22	punct	_	_
28	NB4	nb4	NN	NN	_	22	appos	_	_
29	)	)	-RRB-	-RRB-	_	22	punct	_	_
30	,	,	,	,	_	20	punct	_	_
31	in	in	IN	IN	_	34	case	_	_
32	human	human	JJ	JJ	_	34	amod	_	_
33	diploid	diploid	JJ	JJ	_	34	amod	_	_
34	fibroblasts	fibroblast	NNS	NNS	_	20	conj	_	_
35	and	and	CC	CC	_	20	cc	_	_
36	in	in	IN	IN	_	40	case	_	_
37	human	human	JJ	JJ	_	40	amod	_	_
38	peripheral	peripheral	JJ	JJ	_	40	amod	_	_
39	blood	blood	NN	NN	_	40	compound	_	_
40	leukocytes	leukocyte	NNS	NNS	_	20	conj	_	_
41	.	.	.	.	_	2	punct	_	_

1	Cytokine-induced	cytokine-induced	JJ	JJ	_	2	amod	_	_
2	modulation	modulation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PML	pml	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	assessed	assess	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	Northern	northern	NN	NN	_	11	compound	_	_
10	blot	blot	NN	NN	_	11	compound	_	_
11	analyses	analysis	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	flow	flow	NN	NN	_	15	compound	_	_
14	cytometry	cytometry	NN	NN	_	15	compound	_	_
15	studies	study	NNS	NNS	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	in	in	FW	FW	_	19	amod	_	_
18	situ	situ	FW	FW	_	17	dep	_	_
19	immunolabelling	immunolabelling	NN	NN	_	11	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	IFNs	ifn	NNS	NNS	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-1	il-1	NN	NN	_	5	conj	_	_
8	upregulate	upregulate	VBP	VBP	_	3	ccomp	_	_
9	PML	pml	NN	NN	_	10	compound	_	_
10	transcript	transcript	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	time	time	NN	NN	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	16	conj	_	_
19	manner	manner	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	situ	situ	FW	FW	_	1	dep	_	_
3	immunolabelling	immunolabelling	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	upregulation	upregulation	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IFN-alpha	ifn-alpha	NN	NN	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	a	a	DT	DT	_	14	det	_	_
14	consequence	consequence	NN	NN	_	4	ccomp	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	marked	marked	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	number	number	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	intensity	intensity	NN	NN	_	22	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	staining	staining	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	so-called	so-called	JJ	JJ	_	33	amod	_	_
31	PML	pml	NN	NN	_	33	compound	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	bodies	body	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	stimulation	stimulation	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	PML	pml	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	interferons	interferon	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IL-1	il-1	NN	NN	_	10	conj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	account	account	VB	VB	_	3	ccomp	_	_
15	for	for	IN	IN	_	16	case	_	_
16	upregulation	upregulation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	PML	pml	NN	NN	_	19	compound	_	_
19	proteins	protein	NNS	NNS	_	16	nmod	_	_
20	observed	observe	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	23	case	_	_
22	inflammatory	inflammatory	JJ	JJ	_	23	amod	_	_
23	tissues	tissue	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	in	in	IN	IN	_	27	case	_	_
26	proliferative	proliferative	JJ	JJ	_	27	amod	_	_
27	states	state	NNS	NNS	_	23	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	CCAAT-box	ccaat-box	NN	NN	_	8	compound	_	_
6	binding	binding	NN	NN	_	8	compound	_	_
7	factor	factor	NN	NN	_	8	compound	_	_
8	NF-Y	nf-y	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	modulated	modulate	VBN	VBN	_	0	root	_	_
11	through	through	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	regulated	regulate	VBN	VBN	_	14	amod	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	A	a	NN	NN	_	18	compound	_	_
18	subunit	subunit	NN	NN	_	14	nmod	_	_
19	during	during	IN	IN	_	23	case	_	_
20	monocyte	monocyte	NN	NN	_	23	compound	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	macrophage	macrophage	NN	NN	_	20	dep	_	_
23	differentiation	differentiation	NN	NN	_	10	nmod	_	_
24	:	:	:	:	_	10	punct	_	_
25	regulation	regulation	NN	NN	_	10	dep	_	_
26	of	of	IN	IN	_	28	case	_	_
27	tissue-specific	tissue-specific	JJ	JJ	_	28	amod	_	_
28	genes	gene	NNS	NNS	_	25	nmod	_	_
29	through	through	IN	IN	_	33	case	_	_
30	a	a	DT	DT	_	33	det	_	_
31	ubiquitous	ubiquitous	JJ	JJ	_	33	amod	_	_
32	transcription	transcription	NN	NN	_	33	compound	_	_
33	factor	factor	NN	NN	_	25	nmod	_	_
34	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	analyzed	analyze	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-Y	nf-y	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	during	during	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	monocyte	monocyte	NN	NN	_	17	compound	_	_
15	to	to	TO	TO	_	14	dep	_	_
16	macrophage	macrophage	NN	NN	_	14	dep	_	_
17	maturation	maturation	NN	NN	_	6	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	NF-Y	nf-y	NN	NN	_	9	nsubj	_	_
2	is	be	VBZ	VBZ	_	9	cop	_	_
3	a	a	DT	DT	_	9	det	_	_
4	ubiquitous	ubiquitous	JJ	JJ	_	9	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	evolutionarily	evolutionarily	RB	RB	_	7	advmod	_	_
7	conserved	conserve	VBN	VBN	_	4	conj	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	binds	bind	VBZ	VBZ	_	9	acl:relcl	_	_
12	specifically	specifically	RB	RB	_	11	advmod	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	CCAAT	ccaat	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	11	nmod	_	_
17	present	present	JJ	JJ	_	16	amod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	5'	5'	JJ	JJ	_	22	amod	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	region	region	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	wide	wide	JJ	JJ	_	26	amod	_	_
26	variety	variety	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	genes	gene	NNS	NNS	_	26	nmod	_	_
29	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	in	in	IN	IN	_	7	case	_	_
6	circulating	circulate	VBG	VBG	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	NF-Y	nf-y	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	detected	detect	VBN	VBN	_	2	ccomp	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	CCAAT	ccaat	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	14	nmod	_	_
19	present	present	JJ	JJ	_	18	amod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	promoters	promoter	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	genes	gene	NNS	NNS	_	22	nmod	_	_
25	such	such	JJ	JJ	_	33	case	_	_
26	as	as	IN	IN	_	25	mwe	_	_
27	major	major	JJ	JJ	_	33	amod	_	_
28	histocompatibility	histocompatibility	NN	NN	_	33	compound	_	_
29	complex	complex	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	MHC	mhc	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	class	class	NN	NN	_	22	nmod	_	_
34	II	ii	CD	CD	_	33	nummod	_	_
35	,	,	,	,	_	33	punct	_	_
36	gp91-phox	gp91-phox	NN	NN	_	33	conj	_	_
37	,	,	,	,	_	33	punct	_	_
38	mig	mig	NN	NN	_	33	conj	_	_
39	,	,	,	,	_	33	punct	_	_
40	and	and	CC	CC	_	33	cc	_	_
41	fibronectin	fibronectin	NN	NN	_	33	conj	_	_
42	,	,	,	,	_	14	punct	_	_
43	whereas	whereas	IN	IN	_	56	mark	_	_
44	during	during	IN	IN	_	46	case	_	_
45	macrophage	macrophage	NN	NN	_	46	compound	_	_
46	differentiation	differentiation	NN	NN	_	56	nmod	_	_
47	,	,	,	,	_	56	punct	_	_
48	a	a	DT	DT	_	50	det	_	_
49	progressive	progressive	JJ	JJ	_	50	amod	_	_
50	increase	increase	NN	NN	_	56	nsubjpass	_	_
51	in	in	IN	IN	_	54	case	_	_
52	NF-Y	nf-y	NN	NN	_	54	compound	_	_
53	binding	binding	NN	NN	_	54	compound	_	_
54	activity	activity	NN	NN	_	50	nmod	_	_
55	is	be	VBZ	VBZ	_	56	auxpass	_	_
56	observed	observe	VBN	VBN	_	14	advcl	_	_
57	on	on	IN	IN	_	59	case	_	_
58	these	these	DT	DT	_	59	det	_	_
59	promoters	promoter	NNS	NNS	_	56	nmod	_	_
60	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-Y	nf-y	NN	NN	_	5	compound	_	_
4	subunit	subunit	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	indicates	indicate	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	absence	absence	NN	NN	_	17	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	NF-Y	nf-y	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	circulating	circulate	VBG	VBG	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	caused	cause	VBN	VBN	_	6	ccomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	lack	lack	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	A	a	NN	NN	_	24	compound	_	_
24	subunit	subunit	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	addition	addition	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	recombinant	recombinant	JJ	JJ	_	8	amod	_	_
7	NF-YA	nf-ya	NN	NN	_	8	compound	_	_
8	subunit	subunit	NN	NN	_	3	nmod	_	_
9	restores	restore	VBZ	VBZ	_	0	root	_	_
10	NF-Y	nf-y	NN	NN	_	11	compound	_	_
11	binding	binding	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	lack	lack	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-YA	nf-ya	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	due	due	JJ	JJ	_	13	case	_	_
11	to	to	TO	TO	_	13	case	_	_
12	posttranscriptional	posttranscriptional	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	2	ccomp	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	not	not	RB	RB	_	20	neg	_	_
16	to	to	TO	TO	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	proteolytic	proteolytic	JJ	JJ	_	20	amod	_	_
20	activity	activity	NN	NN	_	13	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	fact	fact	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	NF-YA	nf-ya	NN	NN	_	5	compound	_	_
5	mRNA	mrna	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	present	present	JJ	JJ	_	0	root	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	same	same	JJ	JJ	_	11	amod	_	_
11	level	level	NN	NN	_	7	nmod	_	_
12	at	at	IN	IN	_	14	case	_	_
13	all	all	DT	DT	_	14	det	_	_
14	days	day	NNS	NNS	_	7	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	monocyte	monocyte	NN	NN	_	17	compound	_	_
17	cultivation	cultivation	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	whereas	whereas	IN	IN	_	7	dep	_	_
20	the	the	DT	DT	_	21	det	_	_
21	protein	protein	NN	NN	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	absent	absent	JJ	JJ	_	7	parataxis	_	_
24	in	in	IN	IN	_	27	case	_	_
25	freshly	freshly	RB	RB	_	27	advmod	_	_
26	isolated	isolate	VBN	VBN	_	27	amod	_	_
27	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
28	but	but	CC	CC	_	23	cc	_	_
29	is	be	VBZ	VBZ	_	31	auxpass	_	_
30	progressively	progressively	RB	RB	_	31	advmod	_	_
31	synthesized	synthesize	VBN	VBN	_	23	conj	_	_
32	during	during	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	maturation	maturation	NN	NN	_	35	compound	_	_
35	process	process	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	thus	thus	RB	RB	_	3	advmod	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	NF-YA	nf-ya	NN	NN	_	7	compound	_	_
7	subunit	subunit	NN	NN	_	8	nsubj	_	_
8	plays	play	VBZ	VBZ	_	3	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	relevant	relevant	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	activating	activate	VBG	VBG	_	8	advcl	_	_
14	transcription	transcription	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	genes	gene	NNS	NNS	_	14	nmod	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	expressed	express	VBN	VBN	_	16	acl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	mature	mature	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	line	line	NN	NN	_	8	nmod	_	_
3	with	with	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	conclusion	conclusion	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	show	show	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	32	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cut/CDP	cut/cdp	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	32	nsubj	_	_
13	,	,	,	,	_	12	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	repressor	repressor	NN	NN	_	12	appos	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	inhibits	inhibit	VBZ	VBZ	_	16	acl:relcl	_	_
19	gpc91-phox	gpc91-phox	JJ	JJ	_	21	amod	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	dobj	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	preventing	prevent	VBG	VBG	_	18	advcl	_	_
24	NF-Y	nf-y	NN	NN	_	25	compound	_	_
25	binding	binding	NN	NN	_	23	dobj	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	CAAT	caat	NN	NN	_	29	compound	_	_
29	box	box	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	12	punct	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	absent	absent	JJ	JJ	_	8	ccomp	_	_
33	in	in	IN	IN	_	34	case	_	_
34	monocytes	monocyte	NNS	NNS	_	32	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Mice	mouse	NNS	NNS	_	0	root	_	_
2	lacking	lack	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	CIITA	ciita	NN	NN	_	2	dobj	_	_
7	--	--	:	:	_	1	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	second	second	JJ	JJ	_	10	amod	_	_
10	look	look	NN	NN	_	1	dep	_	_
11	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	generated	generate	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	second	second	JJ	JJ	_	6	amod	_	_
6	line	line	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	mice	mouse	NNS	NNS	_	6	nmod	_	_
9	lacking	lack	VBG	VBG	_	8	acl	_	_
10	a	a	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	9	dobj	_	_
13	thought	think	VBN	VBN	_	12	acl	_	_
14	to	to	TO	TO	_	18	mark	_	_
15	be	be	VB	VB	_	18	cop	_	_
16	a	a	DT	DT	_	18	det	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	regulator	regulator	NN	NN	_	13	xcomp	_	_
19	of	of	IN	IN	_	24	case	_	_
20	MHC	mhc	NN	NN	_	24	compound	_	_
21	class	class	NN	NN	_	24	compound	_	_
22	II	ii	CD	CD	_	24	nummod	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	CIITA	ciita	NN	NN	_	24	appos	_	_
27	(	(	-LRB-	-LRB-	_	31	punct	_	_
28	for	for	IN	IN	_	31	case	_	_
29	class	class	NN	NN	_	31	compound	_	_
30	II	ii	CD	CD	_	31	nummod	_	_
31	transactivator	transactivator	NN	NN	_	26	nmod	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	5	det	_	_
4	previously	previously	RB	RB	_	5	advmod	_	_
5	published	publish	VBN	VBN	_	1	conj	_	_
6	lines	line	NNS	NNS	_	1	dep	_	_
7	differ	differ	VBP	VBP	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	deletion	deletion	NN	NN	_	7	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	engineered	engineer	VBN	VBN	_	10	acl:relcl	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	fact	fact	NN	NN	_	10	conj	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	removed	remove	VBD	VBD	_	17	ccomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	neomycin-resistance	neomycin-resistance	JJ	JJ	_	23	amod	_	_
23	promoter	promoter	NN	NN	_	20	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	structural	structural	JJ	JJ	_	26	amod	_	_
26	gene	gene	NN	NN	_	23	conj	_	_
27	via	via	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	cre-loxP	cre-loxp	JJ	JJ	_	31	amod	_	_
30	recombination	recombination	NN	NN	_	31	compound	_	_
31	system	system	NN	NN	_	20	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	Characterization	characterization	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	line	line	NN	NN	_	1	nmod	_	_
5	led	lead	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	two	two	CD	CD	_	9	nummod	_	_
8	new	new	JJ	JJ	_	9	amod	_	_
9	findings	finding	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	First	first	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	substantial	substantial	JJ	JJ	_	5	amod	_	_
5	number	number	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	5	nmod	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	express	express	VB	VB	_	0	root	_	_
10	class	class	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	molecules	molecule	NNS	NNS	_	9	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	dep	_	_
15	absence	absence	NN	NN	_	17	dep	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CIITA	ciita	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	albeit	albeit	IN	IN	_	23	mark	_	_
20	at	at	IN	IN	_	23	case	_	_
21	5-fold	5-fold	RB	RB	_	23	advmod	_	_
22	reduced	reduce	VBN	VBN	_	23	amod	_	_
23	levels	level	NNS	NNS	_	9	advcl	_	_
24	,	,	,	,	_	9	punct	_	_
25	most	most	RBS	RBS	_	26	advmod	_	_
26	notably	notably	RB	RB	_	28	advmod	_	_
27	dendritic	dendritic	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	9	dobj	_	_
29	in	in	IN	IN	_	32	case	_	_
30	s.c.	s.c.	NN	NN	_	32	compound	_	_
31	lymph	lymph	NN	NN	_	32	compound	_	_
32	nodes	node	NNS	NNS	_	28	nmod	_	_
33	;	;	:	:	_	9	punct	_	_
34	therefore	therefore	RB	RB	_	46	advmod	_	_
35	,	,	,	,	_	46	punct	_	_
36	the	the	DT	DT	_	38	det	_	_
37	CIITA	ciita	NN	NN	_	38	compound	_	_
38	gene	gene	NN	NN	_	46	nsubj	_	_
39	can	can	MD	MD	_	46	aux	_	_
40	not	not	RB	RB	_	46	neg	_	_
41	be	be	VB	VB	_	46	cop	_	_
42	an	a	DT	DT	_	46	det	_	_
43	absolute	absolute	JJ	JJ	_	46	amod	_	_
44	'	'	``	``	_	46	punct	_	_
45	master	master	NN	NN	_	46	compound	_	_
46	gene	gene	NN	NN	_	9	parataxis	_	_
47	'	'	''	''	_	46	punct	_	_
48	controlling	control	VBG	VBG	_	46	acl	_	_
49	the	the	DT	DT	_	50	det	_	_
50	expression	expression	NN	NN	_	48	dobj	_	_
51	of	of	IN	IN	_	54	case	_	_
52	class	class	NN	NN	_	54	compound	_	_
53	II	ii	CD	CD	_	54	nummod	_	_
54	molecules	molecule	NNS	NNS	_	50	nmod	_	_
55	,	,	,	,	_	46	punct	_	_
56	as	as	IN	IN	_	59	mark	_	_
57	had	have	VBD	VBD	_	59	aux	_	_
58	been	be	VBN	VBN	_	59	auxpass	_	_
59	thought	think	VBN	VBN	_	46	advcl	_	_
60	.	.	.	.	_	9	punct	_	_

1	Second	second	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	in	in	IN	IN	_	7	case	_	_
4	contrast	contrast	NN	NN	_	7	dep	_	_
5	to	to	TO	TO	_	7	case	_	_
6	recent	recent	JJ	JJ	_	7	amod	_	_
7	results	result	NNS	NNS	_	17	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	17	punct	_	_
13	CIITA	ciita	NN	NN	_	17	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	17	auxpass	_	_
15	not	not	RB	RB	_	17	neg	_	_
16	critically	critically	RB	RB	_	17	advmod	_	_
17	involved	involve	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	21	amod	_	_
21	up-regulation	up-regulation	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	MHC	mhc	NN	NN	_	26	compound	_	_
24	class	class	NN	NN	_	26	compound	_	_
25	I	i	CD	CD	_	26	nummod	_	_
26	genes	gene	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	17	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-6	il-6	NN	NN	_	4	compound	_	_
4	synthesis	synthesis	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	10	case	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
8	blood	blood	NN	NN	_	10	compound	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	C3a	c3a	NN	NN	_	1	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	C3a(desArg)	c3a(desarg)	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	anaphylatoxin	anaphylatoxin	NN	NN	_	3	compound	_	_
3	C3a	c3a	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	reported	report	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	have	have	VB	VB	_	6	xcomp	_	_
9	immunomodulatory	immunomodulatory	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	number	number	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	different	different	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	types	type	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	C3a	c3a	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	C3a(desArg)	c3a(desarg)	NN	NN	_	9	conj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	secretion	secretion	NN	NN	_	14	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-6	il-6	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	PBMCs	pbmc	NNS	NNS	_	14	nmod	_	_
23	,	,	,	,	_	5	punct	_	_
24	either	either	CC	CC	_	5	dep	_	_
25	alone	alone	RB	RB	_	24	dep	_	_
26	or	or	CC	CC	_	24	cc	_	_
27	in	in	IN	IN	_	28	case	_	_
28	combination	combination	NN	NN	_	24	conj	_	_
29	with	with	IN	IN	_	30	case	_	_
30	LPS	lps	NN	NN	_	28	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	IL-1beta	il-1beta	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	5	punct	_	_

1	C3a	c3a	NN	NN	_	5	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	C3a(desArg)	c3a(desarg)	NN	NN	_	1	conj	_	_
4	alone	alone	RB	RB	_	1	advmod	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	on	on	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	secretion	secretion	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-6	il-6	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	when	when	WRB	WRB	_	6	advmod	_	_
4	PBMC	pbmc	NN	NN	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	stimulated	stimulate	VBN	VBN	_	17	advcl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	LPS	lps	NN	NN	_	6	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	IL-1beta	il-1beta	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	17	punct	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	C3a	c3a	NN	NN	_	17	nsubjpass	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	C3a(desArg)	c3a(desarg)	NN	NN	_	13	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	enhance	enhance	VB	VB	_	17	xcomp	_	_
20	IL-6	il-6	NN	NN	_	21	compound	_	_
21	release	release	NN	NN	_	19	dobj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	PBMC	pbmc	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	dose-dependent	dose-dependent	JJ	JJ	_	27	amod	_	_
27	manner	manner	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	17	punct	_	_

1	Since	since	IN	IN	_	5	mark	_	_
2	C3a	c3a	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	24	advcl	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	induce	induce	VB	VB	_	5	xcomp	_	_
8	PGE2	pge2	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	by	by	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	PGE2	pge2	NN	NN	_	17	nsubjpass	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	shown	show	VBN	VBN	_	5	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	influence	influence	VB	VB	_	17	xcomp	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	19	dobj	_	_
22	,	,	,	,	_	24	punct	_	_
23	we	we	PRP	PRP	_	24	nsubj	_	_
24	investigated	investigate	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	27	det	_	_
26	potential	potential	JJ	JJ	_	27	amod	_	_
27	role	role	NN	NN	_	24	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	PGE2	pge2	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	C3a-mediated	c3a-mediated	JJ	JJ	_	32	amod	_	_
32	enhancement	enhancement	NN	NN	_	27	nmod	_	_
33	of	of	IN	IN	_	38	case	_	_
34	LPS-	lps-	NN	NN	_	38	amod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	IL-1beta-induced	il-1beta-induced	JJ	JJ	_	34	conj	_	_
37	IL-6	il-6	NN	NN	_	38	compound	_	_
38	production	production	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	24	punct	_	_

1	Indomethacin	indomethacin	NN	NN	_	2	nsubj	_	_
2	blocked	block	VBD	VBD	_	0	root	_	_
3	PGE2	pge2	NN	NN	_	4	compound	_	_
4	release	release	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	2	punct	_	_
6	but	but	CC	CC	_	2	cc	_	_
7	had	have	VBD	VBD	_	2	conj	_	_
8	no	no	DT	DT	_	9	neg	_	_
9	influence	influence	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	observed	observe	VBN	VBN	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	C3a	c3a	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	suggesting	suggest	VBG	VBG	_	2	advcl	_	_
18	that	that	IN	IN	_	27	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	effects	effect	NNS	NNS	_	27	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	C3a	c3a	NN	NN	_	20	nmod	_	_
23	on	on	IN	IN	_	25	case	_	_
24	IL-6	il-6	NN	NN	_	25	compound	_	_
25	production	production	NN	NN	_	20	nmod	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	independent	independent	JJ	JJ	_	17	ccomp	_	_
28	of	of	IN	IN	_	30	case	_	_
29	PGE2	pge2	NN	NN	_	30	compound	_	_
30	formation	formation	NN	NN	_	27	nmod	_	_
31	by	by	IN	IN	_	32	case	_	_
32	monocytes	monocyte	NNS	NNS	_	30	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	DT	DT	_	11	mark	_	_
6	C3a	c3a	NN	NN	_	11	nsubj	_	_
7	as	as	RB	RB	_	6	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	C3a(desArg)	c3a(desarg)	NN	NN	_	6	conj	_	_
11	enhanced	enhance	VBD	VBD	_	4	ccomp	_	_
12	LPS-induced	lps-induced	JJ	JJ	_	14	amod	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	11	dobj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	IL-6	il-6	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PBMCs	pbmc	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	6	case	_	_
5	pertussis	pertussis	NN	NN	_	6	compound	_	_
6	toxin	toxin	NN	NN	_	1	nmod	_	_
7	blocked	block	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	functions	function	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	C3a	c3a	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	C3a(desArg)	c3a(desarg)	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	7	punct	_	_
15	indicating	indicate	VBG	VBG	_	7	advcl	_	_
16	that	that	IN	IN	_	24	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	actions	action	NNS	NNS	_	24	nsubjpass	_	_
19	of	of	IN	IN	_	22	case	_	_
20	these	these	DT	DT	_	22	det	_	_
21	two	two	CD	CD	_	22	nummod	_	_
22	molecules	molecule	NNS	NNS	_	18	nmod	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	mediated	mediate	VBN	VBN	_	15	ccomp	_	_
25	by	by	IN	IN	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	G	g	NN	NN	_	28	nmod:npmod	_	_
28	protein-coupled	protein-coupled	JJ	JJ	_	29	amod	_	_
29	pathway	pathway	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	C3a	c3a	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	C3a(desArg)	c3a(desarg)	NN	NN	_	8	conj	_	_
11	on	on	IN	IN	_	12	case	_	_
12	induction	induction	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	activating	activate	VBG	VBG	_	14	conj	_	_
17	protein-1	protein-1	NN	NN	_	18	compound	_	_
18	binding	binding	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	molecules	molecule	NNS	NNS	_	3	nsubj	_	_
3	enhanced	enhance	VBD	VBD	_	0	root	_	_
4	LPS-induced	lps-induced	JJ	JJ	_	5	amod	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activating	activating	NN	NN	_	10	compound	_	_
8	protein-1	protein-1	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	5	conj	_	_
11	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	capacity	capacity	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	intact	intact	JJ	JJ	_	8	amod	_	_
8	C3a	c3a	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
11	circulating	circulate	VBG	VBG	_	13	amod	_	_
12	des-Arg	des-arg	JJ	JJ	_	13	amod	_	_
13	form	form	NN	NN	_	8	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	exert	exert	VB	VB	_	5	acl	_	_
16	immunmodulatory	immunmodulatory	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	15	dobj	_	_
18	in	in	FW	FW	_	19	compound	_	_
19	vitro	vitro	FW	FW	_	15	advmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Comparison	comparison	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	primary	primary	JJ	JJ	_	4	amod	_	_
4	sensitization	sensitization	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	naive	naive	JJ	JJ	_	9	amod	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	varicella-zoster	varicella-zoster	NN	NN	_	13	compound	_	_
12	virus	virus	NN	NN	_	13	compound	_	_
13	peptides	peptide	NNS	NNS	_	4	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	dendritic	dendritic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	4	nmod	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	4	advmod	_	_
19	with	with	IN	IN	_	20	case	_	_
20	responses	response	NNS	NNS	_	1	nmod	_	_
21	elicited	elicit	VBN	VBN	_	20	acl	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vivo	vivo	FW	FW	_	21	advmod	_	_
24	by	by	IN	IN	_	26	case	_	_
25	varicella	varicella	NN	NN	_	26	compound	_	_
26	vaccination	vaccination	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	Dendritic	dendritic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	8	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	DC	dc	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	APC	apc	NN	NN	_	0	root	_	_
9	during	during	IN	IN	_	14	case	_	_
10	primary	primary	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	secondary	secondary	JJ	JJ	_	10	conj	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	objective	objective	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	study	study	NN	NN	_	3	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	determine	determine	VB	VB	_	7	xcomp	_	_
10	whether	whether	IN	IN	_	13	mark	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	DC	dc	NNS	NNS	_	13	nsubj	_	_
13	mediate	mediate	VBP	VBP	_	9	ccomp	_	_
14	in	in	FW	FW	_	16	amod	_	_
15	vitro	vitro	FW	FW	_	14	dep	_	_
16	sensitization	sensitization	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	naive	naive	JJ	JJ	_	21	amod	_	_
19	CD4+	cd4+	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	epitopes	epitope	NNS	NNS	_	16	nmod	_	_
24	of	of	IN	IN	_	32	case	_	_
25	the	the	DT	DT	_	32	det	_	_
26	immediate	immediate	JJ	JJ	_	32	amod	_	_
27	early	early	JJ	JJ	_	32	amod	_	_
28	62	62	CD	CD	_	32	nummod	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	IE62	ie62	NN	NN	_	32	compound	_	_
31	)	)	-RRB-	-RRB-	_	32	punct	_	_
32	protein	protein	NN	NN	_	23	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	varicella	varicella	NN	NN	_	36	compound	_	_
35	zoster	zoster	NN	NN	_	36	compound	_	_
36	virus	virus	NN	NN	_	32	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	VZV	vzv	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	23	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	CD4+	cd4+	JJ	JJ	_	8	amod	_	_
5	T	t	NN	NN	_	8	compound	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	proliferative	proliferative	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	2	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	eight	eight	CD	CD	_	12	nummod	_	_
11	synthetic	synthetic	JJ	JJ	_	12	amod	_	_
12	peptides	peptide	NNS	NNS	_	8	nmod	_	_
13	representing	represent	VBG	VBG	_	12	acl	_	_
14	amino	amino	NN	NN	_	16	compound	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	sequences	sequence	NNS	NNS	_	13	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	VZV	vzv	NN	NN	_	21	compound	_	_
20	IE62	ie62	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	16	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	assessed	assess	VBN	VBN	_	0	root	_	_
24	using	use	VBG	VBG	_	23	xcomp	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	24	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	DC	dc	NNS	NNS	_	26	conj	_	_
29	from	from	IN	IN	_	31	case	_	_
30	VZV-susceptible	vzv-susceptible	JJ	JJ	_	31	amod	_	_
31	donors	donor	NNS	NNS	_	26	nmod	_	_
32	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	objective	objective	NN	NN	_	4	nsubj	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	compare	compare	VB	VB	_	4	xcomp	_	_
7	in	in	FW	FW	_	9	amod	_	_
8	vitro	vitro	FW	FW	_	7	dep	_	_
9	responses	response	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	naive	naive	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	responses	response	NNS	NNS	_	6	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	VZV	vzv	NN	NN	_	18	compound	_	_
18	peptides	peptide	NNS	NNS	_	15	nmod	_	_
19	induced	induce	VBN	VBN	_	15	acl	_	_
20	in	in	FW	FW	_	21	compound	_	_
21	vivo	vivo	FW	FW	_	19	advmod	_	_
22	after	after	IN	IN	_	23	case	_	_
23	immunization	immunization	NN	NN	_	19	nmod	_	_
24	with	with	IN	IN	_	26	case	_	_
25	varicella	varicella	NN	NN	_	26	compound	_	_
26	vaccine	vaccine	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	proliferation	proliferation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	three	three	CD	CD	_	8	nummod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	P1	p1	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	10	punct	_	_
12	P4	p4	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	P7	p7	NN	NN	_	10	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	71-100	71-100	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	5	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	donors	donor	NNS	NNS	_	19	nmod	_	_
23	tested	test	VBN	VBN	_	22	acl	_	_
24	before	before	IN	IN	_	27	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	after	after	IN	IN	_	24	conj	_	_
27	vaccination	vaccination	NN	NN	_	23	nmod	_	_
28	using	use	VBG	VBG	_	27	acl	_	_
29	DC	dc	NNS	NNS	_	28	dobj	_	_
30	as	as	IN	IN	_	31	case	_	_
31	APC	apc	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	4	nsubj	_	_
2	were	be	VBD	VBD	_	4	cop	_	_
3	effective	effective	JJ	JJ	_	4	amod	_	_
4	APC	apc	NN	NN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	VZV	vzv	NN	NN	_	7	compound	_	_
7	peptides	peptide	NNS	NNS	_	4	nmod	_	_
8	only	only	RB	RB	_	10	advmod	_	_
9	after	after	IN	IN	_	10	case	_	_
10	immunization	immunization	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	peptides	peptide	NNS	NNS	_	8	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	P2	p2	NN	NN	_	2	appos	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	P8	p8	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	naive	naive	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	proliferation	proliferation	NN	NN	_	8	dobj	_	_
13	less	less	RBR	RBR	_	14	advmod	_	_
14	effectively	effectively	RB	RB	_	8	advmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	were	be	VBD	VBD	_	19	cop	_	_
17	also	also	RB	RB	_	19	advmod	_	_
18	less	less	RBR	RBR	_	19	advmod	_	_
19	immunogenic	immunogenic	JJ	JJ	_	8	conj	_	_
20	for	for	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	from	from	IN	IN	_	28	case	_	_
24	vaccinated	vaccinate	VBN	VBN	_	28	amod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	naturally	naturally	RB	RB	_	27	advmod	_	_
27	immune	immune	JJ	JJ	_	24	conj	_	_
28	donors	donor	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	recognition	recognition	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	peptides	peptide	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	concordant	concordant	JJ	JJ	_	0	root	_	_
9	between	between	IN	IN	_	13	case	_	_
10	naive	naive	JJ	JJ	_	13	amod	_	_
11	,	,	,	,	_	10	punct	_	_
12	DC-mediated	dc-mediated	JJ	JJ	_	10	dep	_	_
13	responses	response	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	postvaccine	postvaccine	JJ	JJ	_	17	amod	_	_
17	responses	response	NNS	NNS	_	13	conj	_	_
18	using	use	VBG	VBG	_	17	acl	_	_
19	monocytes	monocyte	NNS	NNS	_	18	dobj	_	_
20	as	as	IN	IN	_	21	case	_	_
21	APC	apc	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	69	69	CD	CD	_	24	nummod	_	_
24	%	%	NN	NN	_	8	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	comparisons	comparison	NNS	NNS	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	p	p	NN	NN	_	29	nsubj	_	_
29	=	=	JJ	JJ	_	8	parataxis	_	_
30	0.05	0.05	CD	CD	_	29	dobj	_	_
31	;	;	:	:	_	29	punct	_	_
32	chi2	chi2	NN	NN	_	29	dep	_	_
33	)	)	-RRB-	-RRB-	_	29	punct	_	_
34	;	;	:	:	_	8	punct	_	_
35	the	the	DT	DT	_	37	det	_	_
36	predictive	predictive	JJ	JJ	_	37	amod	_	_
37	value	value	NN	NN	_	56	nsubj	_	_
38	of	of	IN	IN	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	positive	positive	JJ	JJ	_	41	amod	_	_
41	response	response	NN	NN	_	37	nmod	_	_
42	to	to	TO	TO	_	45	case	_	_
43	an	a	DT	DT	_	45	det	_	_
44	IE62	ie62	NN	NN	_	45	compound	_	_
45	peptide	peptide	NN	NN	_	41	nmod	_	_
46	before	before	IN	IN	_	47	case	_	_
47	immunization	immunization	NN	NN	_	41	nmod	_	_
48	for	for	IN	IN	_	51	case	_	_
49	T	t	NN	NN	_	51	compound	_	_
50	cell	cell	NN	NN	_	51	compound	_	_
51	sensitization	sensitization	NN	NN	_	47	nmod	_	_
52	in	in	FW	FW	_	53	compound	_	_
53	vivo	vivo	FW	FW	_	51	advmod	_	_
54	was	be	VBD	VBD	_	56	cop	_	_
55	82	82	CD	CD	_	56	nummod	_	_
56	%	%	NN	NN	_	8	parataxis	_	_
57	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	primary	primary	JJ	JJ	_	8	amod	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	responses	response	NNS	NNS	_	18	nsubj	_	_
9	detected	detect	VBN	VBN	_	8	acl	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	using	use	VBG	VBG	_	8	acl	_	_
13	DC	dc	NNS	NNS	_	12	dobj	_	_
14	as	as	IN	IN	_	15	case	_	_
15	APC	apc	NN	NN	_	12	nmod	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	useful	useful	JJ	JJ	_	3	ccomp	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	characterize	characterize	VB	VB	_	18	xcomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	potential	potential	JJ	JJ	_	23	amod	_	_
23	immunogenicity	immunogenicity	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	viral	viral	JJ	JJ	_	27	amod	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	epitopes	epitope	NNS	NNS	_	23	nmod	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vivo	vivo	FW	FW	_	23	advmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	3	amod	_	_
2	monocyte	monocyte	NN	NN	_	3	compound	_	_
3	adhesion	adhesion	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	adhesion	adhesion	NN	NN	_	7	compound	_	_
6	molecule	molecule	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	conj	_	_
8	in	in	IN	IN	_	13	case	_	_
9	venous	venous	JJ	JJ	_	13	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	arterial	arterial	JJ	JJ	_	9	conj	_	_
12	endothelial	endothelial	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	compared	compare	VBD	VBD	_	0	root	_	_
3	U-937	u-937	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	adhesion	adhesion	NN	NN	_	2	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	adhesion	adhesion	NN	NN	_	9	compound	_	_
8	molecule	molecule	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	conj	_	_
10	in	in	IN	IN	_	23	case	_	_
11	human	human	JJ	JJ	_	23	amod	_	_
12	umbilical	umbilical	JJ	JJ	_	23	amod	_	_
13	venous	venous	JJ	JJ	_	23	amod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HUVECs	huvec	NNS	NNS	_	13	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	arterial	arterial	JJ	JJ	_	13	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HUAECs	huaec	NNS	NNS	_	13	dep	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	2	nmod	_	_
24	exposed	expose	VBN	VBN	_	23	acl	_	_
25	to	to	TO	TO	_	28	case	_	_
26	tumor	tumor	NN	NN	_	28	compound	_	_
27	necrosis	necrosis	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	TNF	tnf	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	28	punct	_	_
33	interleukin-1	interleukin-1	NN	NN	_	28	conj	_	_
34	,	,	,	,	_	28	punct	_	_
35	and	and	CC	CC	_	28	cc	_	_
36	lipopolysaccharide	lipopolysaccharide	NN	NN	_	28	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	LPS	lps	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	2	punct	_	_

1	TNF	tnf	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	LPS	lps	NN	NN	_	1	conj	_	_
4	stimulated	stimulate	VBD	VBD	_	0	root	_	_
5	vascular	vascular	JJ	JJ	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecule	molecule	NN	NN	_	14	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VCAM	vcam	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	-1	-1	CD	CD	_	14	nummod	_	_
13	surface	surface	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	4	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	adhesion	adhesion	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	U-937	u-937	NN	NN	_	20	compound	_	_
19	monocyte-like	monocyte-like	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	16	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	HUVECs	huvec	NNS	NNS	_	16	nmod	_	_
23	but	but	CC	CC	_	24	cc	_	_
24	not	not	RB	RB	_	22	cc	_	_
25	to	to	TO	TO	_	26	case	_	_
26	HUAECs	huaec	NNS	NNS	_	22	conj	_	_
27	.	.	.	.	_	4	punct	_	_

1	Antibody	antibody	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	HUVECs	huvec	NNS	NNS	_	17	nmod	_	_
7	at	at	IN	IN	_	8	case	_	_
8	least	least	JJS	JJS	_	9	nmod:npmod	_	_
9	75	75	CD	CD	_	10	nummod	_	_
10	%	%	NN	NN	_	17	nsubjpass	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	adhesion	adhesion	NN	NN	_	14	compound	_	_
14	response	response	NN	NN	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	VCAM-1	vcam-1	NN	NN	_	17	dep	_	_
17	mediated	mediate	VBN	VBN	_	3	ccomp	_	_
18	.	.	.	.	_	3	punct	_	_

1	Interleukin-1	interleukin-1	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	U-937	u-937	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	adhesion	adhesion	NN	NN	_	2	dobj	_	_
6	to	to	TO	TO	_	5	acl	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	VCAM-1	vcam-1	NN	NN	_	10	compound	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	5	conj	_	_
11	in	in	IN	IN	_	10	acl	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	HUVECs	huvec	NNS	NNS	_	5	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	HUAECs	huaec	NNS	NNS	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NN	NN	_	7	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	the	the	DT	DT	_	6	det	_	_
4	proteasome	proteasome	NN	NN	_	6	compound	_	_
5	inhibitor	inhibitor	NN	NN	_	6	compound	_	_
6	MG-132	mg-132	NN	NN	_	1	conj	_	_
7	blocked	block	VBD	VBD	_	0	root	_	_
8	TNF-	tnf-	NN	NN	_	13	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	LPS-stimulated	lps-stimulated	JJ	JJ	_	8	conj	_	_
11	U-937	u-937	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	adhesion	adhesion	NN	NN	_	7	dobj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	HUVECs	huvec	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	agents	agent	NNS	NNS	_	5	nsubj	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	significantly	significantly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBD	VBD	_	0	root	_	_
6	TNF-	tnf-	NN	NN	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	LPS-stimulated	lps-stimulated	JJ	JJ	_	6	conj	_	_
9	increases	increase	NNS	NNS	_	5	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	HUVEC	huvec	NN	NN	_	13	compound	_	_
12	surface	surface	NN	NN	_	13	compound	_	_
13	VCAM-1	vcam-1	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	TNF	tnf	NN	NN	_	2	nsubj	_	_
2	increased	increase	VBD	VBD	_	0	root	_	_
3	VCAM-1	vcam-1	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	mRNA	mrna	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	HUVECs	huvec	NNS	NNS	_	4	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	blocked	block	VBN	VBN	_	2	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	neither	neither	CC	CC	_	4	cc:preconj	_	_
4	TNF	tnf	NN	NN	_	7	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	LPS	lps	NN	NN	_	4	conj	_	_
7	stimulated	stimulate	VBD	VBD	_	0	root	_	_
8	VCAM-1	vcam-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	HUAECs	huaec	NNS	NNS	_	9	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	TNF	tnf	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	both	both	CC	CC	_	8	cc:preconj	_	_
6	intercellular	intercellular	JJ	JJ	_	8	amod	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	E-selectin	e-selectin	NN	NN	_	8	conj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	HUVECs	huvec	NNS	NNS	_	3	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	but	but	CC	CC	_	2	cc	_	_
15	in	in	IN	IN	_	16	case	_	_
16	HUAECs	huaec	NNS	NNS	_	23	nmod	_	_
17	,	,	,	,	_	23	punct	_	_
18	only	only	RB	RB	_	21	advmod	_	_
19	intercellular	intercellular	JJ	JJ	_	21	amod	_	_
20	adhesion	adhesion	NN	NN	_	21	compound	_	_
21	molecule-1	molecule-1	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	increased	increase	VBN	VBN	_	2	conj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	difference	difference	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	pattern	pattern	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	TNF-stimulated	tnf-stimulated	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	factor-kappaB	factor-kappab	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	10	nmod	_	_
16	between	between	IN	IN	_	17	case	_	_
17	HUVECs	huvec	NNS	NNS	_	7	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	HUAECs	huaec	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	novel	novel	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	striking	striking	JJ	JJ	_	5	conj	_	_
8	insensitivity	insensitivity	NN	NN	_	3	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	arterial	arterial	JJ	JJ	_	11	amod	_	_
11	endothelium	endothelium	NN	NN	_	8	nmod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	effects	effect	NNS	NNS	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	TNF	tnf	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	LPS	lps	NN	NN	_	16	conj	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	indicate	indicate	VBP	VBP	_	3	conj	_	_
21	a	a	DT	DT	_	22	det	_	_
22	dissociation	dissociation	NN	NN	_	20	dobj	_	_
23	between	between	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ability	ability	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HUAECs	huaec	NNS	NNS	_	25	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	upregulate	upregulate	VB	VB	_	25	acl	_	_
30	nuclear	nuclear	JJ	JJ	_	31	amod	_	_
31	factor-kappaB	factor-kappab	NN	NN	_	29	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	VCAM-1	vcam-1	NN	NN	_	31	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	Tissue	tissue	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	suppressed	suppress	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	lysophosphatidylcholine	lysophosphatidylcholine	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	17	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	tissue	tissue	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	TF	tf	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	principal	principal	JJ	JJ	_	12	amod	_	_
12	initiator	initiator	NN	NN	_	5	appos	_	_
13	of	of	IN	IN	_	14	case	_	_
14	coagulation	coagulation	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	increased	increase	VBN	VBN	_	0	root	_	_
18	during	during	IN	IN	_	19	case	_	_
19	inflammation	inflammation	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	atherosclerosis	atherosclerosis	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	17	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	conditions	condition	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	promoted	promote	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	lysophosphatidylcholine	lysophosphatidylcholine	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	lysoPC	lysopc	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	lysoPC	lysopc	NN	NN	_	16	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	1	1	CD	CD	_	12	compound	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	10	10	CD	CD	_	13	nummod	_	_
13	micromol/L	micromol/l	NN	NN	_	8	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	dose-dependently	dose-dependently	RB	RB	_	16	advmod	_	_
16	reduced	reduce	VBD	VBD	_	2	ccomp	_	_
17	TF	tf	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	16	punct	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	elicited	elicit	VBN	VBN	_	16	advcl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	lipopolysaccharide	lipopolysaccharide	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	LPS	lps	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	2	punct	_	_

1	Lysophosphatidylethanolamine	lysophosphatidylethanolamine	NN	NN	_	10	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	lysoPE	lysope	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	other	other	JJ	JJ	_	7	amod	_	_
7	lysophospholipids	lysophospholipid	NNS	NNS	_	1	conj	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affect	affect	VB	VB	_	0	root	_	_
11	LPS-induced	lps-induced	JJ	JJ	_	13	amod	_	_
12	TF	tf	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	TF	tf	NN	NN	_	3	compound	_	_
2	antigen	antigen	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	10	nsubjpass	_	_
4	as	as	IN	IN	_	5	mark	_	_
5	elicited	elicit	VBN	VBN	_	10	dep	_	_
6	by	by	IN	IN	_	7	case	_	_
7	LPS	lps	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	lowered	lower	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	lysoPC	lysopc	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	Phospholipid	phospholipid	NN	NN	_	2	compound	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	selective	selective	JJ	JJ	_	6	amod	_	_
6	increase	increase	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	lysoPC	lysopc	NN	NN	_	10	compound	_	_
10	content	content	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
14	after	after	IN	IN	_	15	case	_	_
15	preincubation	preincubation	NN	NN	_	3	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	lysophospholipid	lysophospholipid	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	LysoPC	lysopc	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TF	tf	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	Mono	mono	NN	NN	_	9	compound	_	_
8	Mac-6	mac-6	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	similar	similar	JJ	JJ	_	13	amod	_	_
13	extent	extent	NN	NN	_	2	nmod	_	_
14	as	as	IN	IN	_	17	case	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	monocytes	monocyte	NNS	NNS	_	13	acl	_	_
18	.	.	.	.	_	2	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	binding	binding	NN	NN	_	15	nsubjpass	_	_
3	to	to	TO	TO	_	6	case	_	_
4	plasma	plasma	NN	NN	_	6	compound	_	_
5	membrane	membrane	NN	NN	_	6	compound	_	_
6	receptors	receptor	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	internalization	internalization	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	LPS	lps	NN	NN	_	8	nmod	_	_
11	into	into	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
13	were	be	VBD	VBD	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	affected	affect	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	lysoPC	lysopc	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	LPS-mediated	lps-mediated	JJ	JJ	_	6	amod	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	binding	binding	NN	NN	_	16	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor-kappaB/Rel	factor-kappab/rel	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	TF-specific	tf-specific	JJ	JJ	_	14	amod	_	_
13	kappaB	kappab	NN	NN	_	14	compound	_	_
14	site	site	NN	NN	_	6	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	inhibited	inhibit	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	lysoPC	lysopc	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	16	punct	_	_

1	Induction	induction	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	TF	tf	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	LPS	lps	NN	NN	_	1	nmod	_	_
8	tended	tend	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	auxpass	_	_
11	partially	partially	RB	RB	_	12	advmod	_	_
12	reduced	reduce	VBN	VBN	_	8	xcomp	_	_
13	by	by	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	lysophospholipid	lysophospholipid	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Preincubation	preincubation	NN	NN	_	4	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	lysoPC	lysopc	NN	NN	_	1	nmod	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	monocytic	monocytic	JJ	JJ	_	7	amod	_	_
6	cAMP	camp	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	4	dobj	_	_
8	.	.	.	.	_	4	punct	_	_

1	Inhibition	inhibition	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	adenylyl	adenylyl	JJ	JJ	_	4	amod	_	_
4	cyclase	cyclase	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	pretreatment	pretreatment	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	2'-deoxy-3'-adenosine	2'-deoxy-3'-adenosine	JJ	JJ	_	9	amod	_	_
9	monophosphate	monophosphate	NN	NN	_	6	nmod	_	_
10	partially	partially	RB	RB	_	11	advmod	_	_
11	reversed	reverse	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	inhibition	inhibition	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	TF	tf	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	nmod	_	_
17	promoted	promote	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	lysoPC	lysopc	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	lysoPC	lysopc	NN	NN	_	6	nsubj	_	_
5	markedly	markedly	RB	RB	_	6	advmod	_	_
6	decreases	decrease	VBZ	VBZ	_	0	root	_	_
7	LPS-mediated	lps-mediated	JJ	JJ	_	9	amod	_	_
8	TF	tf	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effect	effect	NN	NN	_	6	dobj	_	_
16	probably	probably	RB	RB	_	18	advmod	_	_
17	being	be	VBG	VBG	_	18	auxpass	_	_
18	mediated	mediate	VBN	VBN	_	15	acl	_	_
19	by	by	IN	IN	_	24	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	posttranscriptional	posttranscriptional	JJ	JJ	_	21	conj	_	_
24	mechanisms	mechanism	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	LysoPC	lysopc	NN	NN	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	attenuate	attenuate	VB	VB	_	0	root	_	_
5	activation	activation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	coagulation	coagulation	NN	NN	_	5	nmod	_	_
8	during	during	IN	IN	_	9	case	_	_
9	inflammation	inflammation	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	atherosclerosis	atherosclerosis	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Intranuclear	intranuclear	JJ	JJ	_	3	amod	_	_
2	targeted	target	VBN	VBN	_	3	amod	_	_
3	delivery	delivery	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	12	case	_	_
8	70	70	CD	CD	_	12	nummod	_	_
9	kDa	kda	NN	NN	_	12	compound	_	_
10	heat	heat	NN	NN	_	12	compound	_	_
11	shock	shock	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	70	70	CD	CD	_	6	nummod	_	_
3	kDa	kda	NN	NN	_	6	compound	_	_
4	heat	heat	NN	NN	_	6	compound	_	_
5	shock	shock	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	16	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	Hsp70	hsp70	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	16	cop	_	_
11	a	a	DT	DT	_	16	det	_	_
12	highly	highly	RB	RB	_	13	advmod	_	_
13	conserved	conserve	VBN	VBN	_	16	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	ubiquitous	ubiquitous	JJ	JJ	_	13	dep	_	_
16	protein	protein	NN	NN	_	0	root	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	chaperoning	chaperon	VBG	VBG	_	17	advcl	_	_
20	proteins	protein	NNS	NNS	_	19	dobj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	various	various	JJ	JJ	_	24	amod	_	_
23	cellular	cellular	JJ	JJ	_	24	amod	_	_
24	organelles	organelle	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	when	when	WRB	WRB	_	6	advmod	_	_
6	added	add	VBN	VBN	_	14	advcl	_	_
7	exogenously	exogenously	RB	RB	_	6	advmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	Hsp70	hsp70	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	readily	readily	RB	RB	_	14	advmod	_	_
14	imported	import	VBN	VBN	_	3	ccomp	_	_
15	into	into	IN	IN	_	20	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	cytoplasmic	cytoplasmic	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	nuclear	nuclear	JJ	JJ	_	17	conj	_	_
20	compartments	compartment	NNS	NNS	_	14	nmod	_	_
21	in	in	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	cell-type-specific	cell-type-specific	JJ	JJ	_	24	amod	_	_
24	fashion	fashion	NN	NN	_	14	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	exploited	exploit	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Hsp70	hsp70	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	deliver	deliver	VB	VB	_	4	acl	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	14	det	_	_
12	key	key	JJ	JJ	_	14	amod	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	regulator	regulator	NN	NN	_	9	appos	_	_
15	of	of	IN	IN	_	17	case	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	responses	response	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	20	mark	_	_
4	a	a	DT	DT	_	6	det	_	_
5	fusion	fusion	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	20	nsubjpass	_	_
7	composed	compose	VBN	VBN	_	6	acl	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	C-terminal	c-terminal	JJ	JJ	_	12	amod	_	_
11	Hsp70	hsp70	NN	NN	_	12	compound	_	_
12	peptide	peptide	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	16	det	_	_
15	p50	p50	NN	NN	_	16	compound	_	_
16	subunit	subunit	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	16	nmod	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	directed	direct	VBN	VBN	_	2	ccomp	_	_
21	into	into	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	nucleus	nucleus	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	cells	cell	NNS	NNS	_	23	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	could	could	MD	MD	_	28	aux	_	_
28	bind	bind	VB	VB	_	20	conj	_	_
29	DNA	dna	NN	NN	_	28	dobj	_	_
30	specifically	specifically	RB	RB	_	28	advmod	_	_
31	,	,	,	,	_	20	punct	_	_
32	and	and	CC	CC	_	20	cc	_	_
33	activated	activate	VBD	VBD	_	20	conj	_	_
34	Igkappa	igkappa	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	33	dobj	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	TNFalpha	tnfalpha	NN	NN	_	38	compound	_	_
38	production	production	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	propose	propose	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	Hsp70	hsp70	NN	NN	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	3	ccomp	_	_
9	as	as	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	vehicle	vehicle	NN	NN	_	8	nmod	_	_
12	for	for	IN	IN	_	16	case	_	_
13	intracytoplasmic	intracytoplasmic	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	intranuclear	intranuclear	JJ	JJ	_	13	conj	_	_
16	delivery	delivery	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	proteins	protein	NNS	NNS	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	DNA	dna	NN	NN	_	18	conj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	modulate	modulate	VB	VB	_	8	xcomp	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	thereby	thereby	RB	RB	_	22	advmod	_	_
27	control	control	VB	VB	_	22	dep	_	_
28	immune	immune	JJ	JJ	_	29	amod	_	_
29	responses	response	NNS	NNS	_	27	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-4	il-4	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	JunB	junb	NN	NN	_	1	nmod	_	_
10	during	during	IN	IN	_	14	case	_	_
11	T	t	NN	NN	_	14	compound	_	_
12	helper	helper	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	differentiation	differentiation	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	24	nsubj	_	_
4	for	for	IN	IN	_	7	case	_	_
5	restricted	restricted	JJ	JJ	_	7	amod	_	_
6	cytokine	cytokine	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	22	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	helper	helper	NN	NN	_	22	compound	_	_
11	1	1	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Th1	th1	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	and	and	CC	CC	_	22	cc	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	helper	helper	NN	NN	_	22	compound	_	_
18	2	2	CD	CD	_	17	nummod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	Th2	th2	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	cells	cell	NNS	NNS	_	7	nmod	_	_
23	is	be	VBZ	VBZ	_	24	cop	_	_
24	unclear	unclear	JJ	JJ	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	P1	p1	NN	NN	_	22	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	an	a	DT	DT	_	8	det	_	_
8	element	element	NN	NN	_	5	appos	_	_
9	of	of	IN	IN	_	16	case	_	_
10	the	the	DT	DT	_	16	det	_	_
11	interleukin	interleukin	NN	NN	_	16	compound	_	_
12	4	4	CD	CD	_	16	nummod	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	IL-4	il-4	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	promoter	promoter	NN	NN	_	8	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	binds	bind	VBZ	VBZ	_	16	acl:relcl	_	_
19	AP-1	ap-1	NN	NN	_	18	dobj	_	_
20	,	,	,	,	_	5	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	important	important	JJ	JJ	_	3	ccomp	_	_
23	for	for	IN	IN	_	26	case	_	_
24	Th2-restricted	th2-restricted	JJ	JJ	_	26	amod	_	_
25	IL-4	il-4	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	JunB	junb	NN	NN	_	17	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	the	the	DT	DT	_	13	det	_	_
10	other	other	JJ	JJ	_	13	amod	_	_
11	Jun	jun	NN	NN	_	13	compound	_	_
12	family	family	NN	NN	_	13	compound	_	_
13	members	member	NNS	NNS	_	5	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	selectively	selectively	RB	RB	_	17	advmod	_	_
17	induced	induce	VBN	VBN	_	3	ccomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	not	not	RB	RB	_	25	neg	_	_
23	in	in	IN	IN	_	25	case	_	_
24	Th1	th1	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	conj	_	_
26	during	during	IN	IN	_	27	case	_	_
27	differentiation	differentiation	NN	NN	_	17	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	JunB	junb	NN	NN	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	previously	previously	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	considered	consider	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	10	mark	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	5	xcomp	_	_
11	of	of	IN	IN	_	12	case	_	_
12	transcription	transcription	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	JunB	junb	NN	NN	_	7	nsubj	_	_
7	binds	bind	VBZ	VBZ	_	4	ccomp	_	_
8	directly	directly	RB	RB	_	12	advmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	P1	p1	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	synergizes	synergize	VBZ	VBZ	_	7	conj	_	_
15	with	with	IN	IN	_	16	case	_	_
16	c-Maf	c-maf	NN	NN	_	14	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	activate	activate	VB	VB	_	7	xcomp	_	_
19	an	a	DT	DT	_	23	det	_	_
20	IL-4	il-4	NN	NN	_	23	compound	_	_
21	luciferase	luciferase	NN	NN	_	23	compound	_	_
22	reporter	reporter	NN	NN	_	23	compound	_	_
23	gene	gene	NN	NN	_	18	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	JunB-control	junb-control	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-4	il-4	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	JunB	junb	NN	NN	_	9	nmod	_	_
12	at	at	IN	IN	_	13	case	_	_
13	Thr102	thr102	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-104	-104	CD	CD	_	13	conj	_	_
16	by	by	IN	IN	_	19	case	_	_
17	JNK	jnk	NN	NN	_	19	compound	_	_
18	MAP	map	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	synergy	synergy	NN	NN	_	9	nsubjpass	_	_
3	between	between	IN	IN	_	4	case	_	_
4	c-Maf	c-maf	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	JunB	junb	NN	NN	_	4	conj	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	attributed	attribute	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	13	case	_	_
11	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
12	DNA	dna	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	facilitated	facilitate	VBN	VBN	_	13	acl:relcl	_	_
18	by	by	IN	IN	_	20	case	_	_
19	JunB	junb	NN	NN	_	20	compound	_	_
20	phosphorylation	phosphorylation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	transgenic	transgenic	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	elevated	elevated	JJ	JJ	_	7	amod	_	_
6	JunB	junb	NN	NN	_	7	compound	_	_
7	levels	level	NNS	NNS	_	8	nsubj	_	_
8	caused	cause	VBD	VBD	_	0	root	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	several	several	JJ	JJ	_	14	amod	_	_
13	Th2	th2	NN	NN	_	14	compound	_	_
14	cytokines	cytokine	NNS	NNS	_	10	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	developing	develop	VBG	VBG	_	18	amod	_	_
17	Th1	th1	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	10	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	JunB	junb	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	upregulated	upregulate	VBD	VBD	_	0	root	_	_
4	IL-4	il-4	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	response	response	NN	NN	_	9	dep	_	_
8	to	to	TO	TO	_	9	case	_	_
9	immunization	immunization	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	early	early	JJ	JJ	_	5	amod	_	_
5	increase	increase	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	JunB	junb	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Th2	th2	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	provide	provide	VB	VB	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	specificity	specificity	NN	NN	_	13	dobj	_	_
16	for	for	IN	IN	_	17	case	_	_
17	c-Maf	c-maf	NN	NN	_	15	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	IL-4	il-4	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	15	nmod	_	_
21	during	during	IN	IN	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	13	nmod	_	_
25	and	and	CC	CC	_	13	cc	_	_
26	directs	direct	VBZ	VBZ	_	13	conj	_	_
27	thereby	thereby	RB	RB	_	26	advmod	_	_
28	Th2	th2	NN	NN	_	29	compound	_	_
29	differentiation	differentiation	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	13	punct	_	_

1	CD2	cd2	NN	NN	_	2	compound	_	_
2	signalling	signalling	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	phosphorylation	phosphorylation	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CREB	creb	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	primary	primary	JJ	JJ	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	sequences	sequence	NNS	NNS	_	11	nsubjpass	_	_
3	responsive	responsive	JJ	JJ	_	2	amod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	cyclic	cyclic	JJ	JJ	_	6	amod	_	_
6	AMP	amp	NN	NN	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	cAMP	camp	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	bind	bind	VBP	VBP	_	11	conj	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	20	dobj	_	_
23	of	of	IN	IN	_	40	case	_	_
24	the	the	DT	DT	_	40	det	_	_
25	cAMP	camp	NN	NN	_	29	compound	_	_
26	response	response	NN	NN	_	29	compound	_	_
27	element	element	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	40	compound	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CREB	creb	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	/	/	:	:	_	40	punct	_	_
34	activating	activating	JJ	JJ	_	36	amod	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factor-1	factor-1	NN	NN	_	40	compound	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	ATF-1	atf-1	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	family	family	NN	NN	_	22	nmod	_	_
41	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	13	det	_	_
5	human	human	JJ	JJ	_	8	amod	_	_
6	T-lymphotropic	t-lymphotropic	JJ	JJ	_	8	amod	_	_
7	virus	virus	NN	NN	_	8	compound	_	_
8	type	type	NN	NN	_	13	compound	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HTLV-1	htlv-1	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	model	model	NN	NN	_	3	dobj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	cAMP	camp	NN	NN	_	17	compound	_	_
16	response	response	NN	NN	_	17	compound	_	_
17	element	element	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CRE	cre	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	transcription	transcription	NN	NN	_	13	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	investigate	investigate	VB	VB	_	3	advcl	_	_
24	the	the	DT	DT	_	25	det	_	_
25	influence	influence	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	lymphocyte	lymphocyte	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	25	nmod	_	_
29	on	on	IN	IN	_	30	case	_	_
30	transcription	transcription	NN	NN	_	25	nmod	_	_
31	from	from	IN	IN	_	33	case	_	_
32	homologous	homologous	JJ	JJ	_	33	amod	_	_
33	regions	region	NNS	NNS	_	30	nmod	_	_
34	in	in	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	viral	viral	JJ	JJ	_	37	amod	_	_
37	promoter	promoter	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	increased	increase	VBN	VBN	_	6	amod	_	_
5	HTLV-1	htlv-1	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	3	dobj	_	_
7	following	follow	VBG	VBG	_	13	case	_	_
8	CD2	cd2	NN	NN	_	13	compound	_	_
9	but	but	CC	CC	_	10	cc	_	_
10	not	not	RB	RB	_	8	cc	_	_
11	CD3	cd3	NN	NN	_	8	conj	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	cross-linking	cross-linking	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	this	this	DT	DT	_	7	det	_	_
5	increased	increase	VBN	VBN	_	7	amod	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	transcription	transcription	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	in	in	IN	IN	_	12	case	_	_
12	part	part	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	through	through	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CREB	creb	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	CD2	cd2	NN	NN	_	8	dep	_	_
6	and	and	CC	CC	_	8	cc	_	_
7	CD3	cd3	NN	NN	_	8	conj	_	_
8	receptor-mediated	receptor-mediated	JJ	JJ	_	9	amod	_	_
9	signalling	signalling	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	16	case	_	_
11	primary	primary	JJ	JJ	_	16	amod	_	_
12	human	human	JJ	JJ	_	16	amod	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PBMC	pbmc	NNS	NNS	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	4	punct	_	_

1	CD2	cd2	NN	NN	_	7	compound	_	_
2	,	,	,	,	_	1	punct	_	_
3	but	but	CC	CC	_	4	cc	_	_
4	not	not	RB	RB	_	1	cc	_	_
5	CD3	cd3	NN	NN	_	1	conj	_	_
6	,	,	,	,	_	1	punct	_	_
7	cross-linking	cross-linking	NN	NN	_	8	nsubj	_	_
8	increased	increase	VBD	VBD	_	0	root	_	_
9	cAMP	camp	NN	NN	_	8	dobj	_	_
10	detected	detect	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	15	case	_	_
12	competitive	competitive	JJ	JJ	_	15	amod	_	_
13	enzyme-linked	enzyme-linked	JJ	JJ	_	15	amod	_	_
14	immunosorbent	immunosorbent	JJ	JJ	_	15	amod	_	_
15	assay	assay	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	ELISA	elisa	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	approximately	approximately	RB	RB	_	20	advmod	_	_
20	fourfold	fourfold	RB	RB	_	8	advmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	CD2	cd2	NN	NN	_	2	compound	_	_
2	cross-linking	cross-linking	NN	NN	_	4	nsubj	_	_
3	concurrently	concurrently	RB	RB	_	4	advmod	_	_
4	increased	increase	VBD	VBD	_	0	root	_	_
5	phosphorylation	phosphorylation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CREB	creb	NN	NN	_	5	nmod	_	_
8	detected	detect	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	immunoblot	immunoblot	NN	NN	_	11	compound	_	_
11	assay	assay	NN	NN	_	8	nmod	_	_
12	eightfold	eightfold	RB	RB	_	4	advmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Consistent	consistent	JJ	JJ	_	15	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	post-translational	post-translational	JJ	JJ	_	4	amod	_	_
4	regulation	regulation	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	change	change	NN	NN	_	15	nsubjpass	_	_
8	in	in	IN	IN	_	10	case	_	_
9	total	total	JJ	JJ	_	10	amod	_	_
10	level	level	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CREB	creb	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	10	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	observed	observe	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CREB	creb	NN	NN	_	1	nmod	_	_
4	occurred	occur	VBD	VBD	_	0	root	_	_
5	through	through	IN	IN	_	11	case	_	_
6	a	a	DT	DT	_	11	det	_	_
7	herbimycin	herbimycin	NN	NN	_	8	compound	_	_
8	A	a	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Rp-cAMP-sensitive	rp-camp-sensitive	JJ	JJ	_	8	conj	_	_
11	pathway	pathway	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	suggesting	suggest	VBG	VBG	_	4	xcomp	_	_
14	phosphorylation	phosphorylation	NN	NN	_	15	nsubj	_	_
15	required	require	VBD	VBD	_	13	ccomp	_	_
16	antecedent	antecedent	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	both	both	CC	CC	_	22	cc:preconj	_	_
20	protein	protein	NN	NN	_	22	compound	_	_
21	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
22	kinases	kinase	NNS	NNS	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PTK	ptk	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	protein	protein	NN	NN	_	29	compound	_	_
28	kinase	kinase	NN	NN	_	29	compound	_	_
29	A	a	NN	NN	_	22	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PKA	pka	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	CD2	cd2	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CD3	cd3	NN	NN	_	5	compound	_	_
5	cross-linking	cross-linking	NN	NN	_	2	conj	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	binding	binding	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	proteins	protein	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	16	case	_	_
12	a	a	DT	DT	_	16	det	_	_
13	radiolabelled	radiolabelled	JJ	JJ	_	16	amod	_	_
14	CRE	cre	NN	NN	_	16	compound	_	_
15	oligonucleotide	oligonucleotide	NN	NN	_	16	compound	_	_
16	probe	probe	NN	NN	_	7	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	electrophoretic	electrophoretic	JJ	JJ	_	21	amod	_	_
19	mobility	mobility	NN	NN	_	21	compound	_	_
20	shift	shift	NN	NN	_	21	compound	_	_
21	assays	assay	NNS	NNS	_	6	nmod	_	_
22	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	lymphocyte	lymphocyte	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	26	nsubj	_	_
26	enhances	enhance	VBZ	VBZ	_	22	ccomp	_	_
27	binding	binding	NN	NN	_	26	dobj	_	_
28	independently	independently	RB	RB	_	26	advmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	phosphorylation	phosphorylation	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	CREB	creb	NN	NN	_	30	nmod	_	_
33	at	at	IN	IN	_	34	case	_	_
34	serine	serine	NN	NN	_	26	nmod	_	_
35	133	133	CD	CD	_	34	nummod	_	_
36	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	modulation	modulation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CREB/ATF-1	creb/atf-1	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	CD2	cd2	NN	NN	_	17	compound	_	_
16	signalling	signalling	NN	NN	_	17	compound	_	_
17	pathway	pathway	NN	NN	_	5	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	suggest	suggest	VBP	VBP	_	3	conj	_	_
20	CD2	cd2	NN	NN	_	22	compound	_	_
21	receptor	receptor	NN	NN	_	22	compound	_	_
22	modulation	modulation	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	CRE-mediated	cre-mediated	JJ	JJ	_	25	amod	_	_
25	transcription	transcription	NN	NN	_	22	nmod	_	_
26	following	follow	VBG	VBG	_	28	case	_	_
27	ligand	ligand	NN	NN	_	28	compound	_	_
28	engagement	engagement	NN	NN	_	25	nmod	_	_
29	(	(	-LRB-	-LRB-	_	28	punct	_	_
30	e.g.	e.g.	FW	FW	_	32	dep	_	_
31	cell-to-cell	cell-to-cell	JJ	JJ	_	32	amod	_	_
32	contact	contact	NN	NN	_	28	nmod	_	_
33	)	)	-RRB-	-RRB-	_	28	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	Anoxia/reoxygenation-induced	anoxia/reoxygenation-induced	JJ	JJ	_	2	amod	_	_
2	tolerance	tolerance	NN	NN	_	0	root	_	_
3	with	with	IN	IN	_	8	case	_	_
4	respect	respect	NN	NN	_	8	dep	_	_
5	to	to	TO	TO	_	8	case	_	_
6	polymorphonuclear	polymorphonuclear	JJ	JJ	_	8	amod	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	adhesion	adhesion	NN	NN	_	2	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	cultured	culture	VBN	VBN	_	12	amod	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	factor-kappaB-mediated	factor-kappab-mediated	JJ	JJ	_	4	amod	_	_
4	phenomenon	phenomenon	NN	NN	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Exposing	expose	VBG	VBG	_	15	csubj	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	umbilical	umbilical	JJ	JJ	_	6	amod	_	_
4	vein	vein	NN	NN	_	6	compound	_	_
5	endothelial	endothelial	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	1	dobj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HUVECs	huvec	NNS	NNS	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	to	to	TO	TO	_	11	case	_	_
11	anoxia/reoxygenation	anoxia/reoxygenation	NN	NN	_	1	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	A/R	a/r	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	results	result	VBZ	VBZ	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	an	a	DT	DT	_	18	det	_	_
18	increase	increase	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	25	case	_	_
20	polymorphonuclear	polymorphonuclear	JJ	JJ	_	21	amod	_	_
21	leukocyte	leukocyte	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PMN	pmn	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	adhesion	adhesion	NN	NN	_	18	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	HUVECs	huvec	NNS	NNS	_	25	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	A/R-induced	a/r-induced	JJ	JJ	_	3	amod	_	_
3	hyperadhesion	hyperadhesion	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	completely	completely	RB	RB	_	6	advmod	_	_
6	prevented	prevent	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	15	case	_	_
8	a	a	DT	DT	_	15	det	_	_
9	previous	previous	JJ	JJ	_	15	amod	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	24	24	CD	CD	_	12	nummod	_	_
12	hours	hour	NNS	NNS	_	13	nmod:npmod	_	_
13	earlier	earlier	RBR	RBR	_	15	dep	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	exposure	exposure	NN	NN	_	6	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HUVECs	huvec	NNS	NNS	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	A/R	a/r	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenomenon	phenomenon	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	termed	term	VBN	VBN	_	0	root	_	_
6	``	``	``	``	_	8	punct	_	_
7	A/R	a/r	NN	NN	_	8	compound	_	_
8	tolerance	tolerance	NN	NN	_	5	xcomp	_	_
9	.	.	.	.	_	5	punct	_	_

1	Exposing	expose	VBG	VBG	_	5	csubj	_	_
2	HUVECs	huvec	NNS	NNS	_	1	dobj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	A/R	a/r	NN	NN	_	1	nmod	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	an	a	DT	DT	_	7	det	_	_
7	increase	increase	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	kappaB	kappab	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	HUVEC	huvec	NN	NN	_	17	compound	_	_
17	nuclei	nucleus	NNS	NNS	_	11	nmod	_	_
18	within	within	IN	IN	_	20	case	_	_
19	4	4	CD	CD	_	20	nummod	_	_
20	hours	hour	NNS	NNS	_	5	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Interfering	interfere	VBG	VBG	_	20	csubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	either	either	CC	CC	_	5	cc:preconj	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	proteasome	proteasome	NN	NN	_	8	compound	_	_
8	inhibitor	inhibitor	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	or	or	CC	CC	_	5	cc	_	_
11	translocation	translocation	NN	NN	_	5	conj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	double-stranded	double-stranded	JJ	JJ	_	14	amod	_	_
14	oligonucleotides	oligonucleotide	NNS	NNS	_	11	dep	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	15	dobj	_	_
19	)	)	-RRB-	-RRB-	_	14	punct	_	_
20	prevents	prevent	VBZ	VBZ	_	0	root	_	_
21	the	the	DT	DT	_	22	det	_	_
22	development	development	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	A/R	a/r	NN	NN	_	25	compound	_	_
25	tolerance	tolerance	NN	NN	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	39	punct	_	_
27	ie	ie	FW	FW	_	39	advmod	_	_
28	,	,	,	,	_	39	punct	_	_
29	the	the	DT	DT	_	30	det	_	_
30	increase	increase	NN	NN	_	39	nsubj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	A/R-induced	a/r-induced	JJ	JJ	_	34	amod	_	_
33	PMN	pmn	NN	NN	_	34	compound	_	_
34	adhesion	adhesion	NN	NN	_	30	nmod	_	_
35	to	to	TO	TO	_	36	case	_	_
36	HUVECs	huvec	NNS	NNS	_	34	nmod	_	_
37	is	be	VBZ	VBZ	_	39	cop	_	_
38	the	the	DT	DT	_	39	det	_	_
39	same	same	JJ	JJ	_	20	parataxis	_	_
40	after	after	IN	IN	_	46	case	_	_
41	the	the	DT	DT	_	46	det	_	_
42	first	first	JJ	JJ	_	46	amod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	second	second	JJ	JJ	_	42	conj	_	_
45	A/R	a/r	NN	NN	_	46	compound	_	_
46	challenges	challenge	NNS	NNS	_	39	nmod	_	_
47	)	)	-RRB-	-RRB-	_	39	punct	_	_
48	.	.	.	.	_	20	punct	_	_

1	NO	no	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	6	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	HUVECs	huvec	NNS	NNS	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	increased	increase	VBN	VBN	_	0	root	_	_
7	after	after	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	second	second	JJ	JJ	_	11	amod	_	_
10	A/R	a/r	NN	NN	_	11	compound	_	_
11	challenge	challenge	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	11	cc	_	_
15	after	after	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	first	first	JJ	JJ	_	19	amod	_	_
18	A/R	a/r	NN	NN	_	19	compound	_	_
19	challenge	challenge	NN	NN	_	11	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NO	no	DT	DT	_	4	neg	_	_
4	synthase	synthase	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NOS	nos	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	during	during	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	second	second	JJ	JJ	_	12	amod	_	_
11	A/R	a/r	NN	NN	_	12	compound	_	_
12	challenge	challenge	NN	NN	_	1	nmod	_	_
13	prevents	prevent	VBZ	VBZ	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	development	development	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	A/R	a/r	NN	NN	_	18	compound	_	_
18	tolerance	tolerance	NN	NN	_	15	nmod	_	_
19	with	with	IN	IN	_	23	case	_	_
20	respect	respect	NN	NN	_	23	dep	_	_
21	to	to	TO	TO	_	23	case	_	_
22	PMN	pmn	NN	NN	_	23	compound	_	_
23	adhesion	adhesion	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	while	while	IN	IN	_	5	mark	_	_
4	HUVECs	huvec	NNS	NNS	_	5	nsubj	_	_
5	contained	contain	VBD	VBD	_	14	advcl	_	_
6	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
7	NOS	nos	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	14	punct	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	inducible	inducible	JJ	JJ	_	12	amod	_	_
12	NOS	nos	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	20	case	_	_
16	either	either	CC	CC	_	17	cc:preconj	_	_
17	tolerant	tolerant	JJ	JJ	_	20	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	nontolerant	nontolerant	JJ	JJ	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	27	mark	_	_
5	inhibition	inhibition	NN	NN	_	27	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GTP-cyclohydrolase	gtp-cyclohydrolase	NN	NN	_	5	nmod	_	_
8	I	i	CD	CD	_	7	nummod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	an	a	DT	DT	_	11	det	_	_
11	enzyme	enzyme	NN	NN	_	7	appos	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	16	case	_	_
14	de	de	FW	FW	_	16	amod	_	_
15	novo	novo	FW	FW	_	14	dep	_	_
16	synthesis	synthesis	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	cofactor	cofactor	NN	NN	_	16	nmod	_	_
21	for	for	IN	IN	_	23	case	_	_
22	NOS	nos	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	11	punct	_	_
25	tetrahydrobiopterin	tetrahydrobiopterin	NN	NN	_	11	dep	_	_
26	)	)	-RRB-	-RRB-	_	11	punct	_	_
27	prevented	prevent	VBD	VBD	_	3	ccomp	_	_
28	the	the	DT	DT	_	29	det	_	_
29	generation	generation	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	NO	no	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	A/R-tolerant	a/r-tolerant	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Extracellular	extracellular	JJ	JJ	_	2	amod	_	_
2	generation	generation	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NO	no	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	NO	no	NN	NN	_	7	compound	_	_
7	donor	donor	NN	NN	_	2	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	effect	effect	VB	VB	_	0	root	_	_
12	the	the	DT	DT	_	14	det	_	_
13	hyperadhesion	hyperadhesion	NN	NN	_	14	compound	_	_
14	response	response	NN	NN	_	11	dobj	_	_
15	induced	induce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	initial	initial	JJ	JJ	_	20	amod	_	_
19	A/R	a/r	NN	NN	_	20	compound	_	_
20	challenge	challenge	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	A/R	a/r	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	oxidant	oxidant	JJ	JJ	_	6	amod	_	_
6	stress	stress	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	naive	naive	JJ	JJ	_	9	amod	_	_
9	HUVECs	huvec	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	but	but	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	in	in	IN	IN	_	15	case	_	_
14	A/R-tolerant	a/r-tolerant	JJ	JJ	_	15	amod	_	_
15	HUVECs	huvec	NNS	NNS	_	9	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NOS	nos	NN	NN	_	1	nmod	_	_
4	during	during	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	second	second	JJ	JJ	_	8	amod	_	_
7	A/R	a/r	NN	NN	_	8	compound	_	_
8	insult	insult	NN	NN	_	1	nmod	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	generation	generation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	an	a	DT	DT	_	16	det	_	_
15	oxidant	oxidant	JJ	JJ	_	16	amod	_	_
16	stress	stress	NN	NN	_	12	nmod	_	_
17	similar	similar	JJ	JJ	_	16	amod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	that	that	DT	DT	_	17	nmod	_	_
20	observed	observe	VBN	VBN	_	19	acl	_	_
21	after	after	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	first	first	JJ	JJ	_	25	amod	_	_
24	A/R	a/r	NN	NN	_	25	compound	_	_
25	challenge	challenge	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Taken	take	VBN	VBN	_	11	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	11	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	present	present	JJ	JJ	_	9	amod	_	_
9	study	study	NN	NN	_	5	nmod	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	consistent	consistent	JJ	JJ	_	0	root	_	_
12	with	with	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	role	role	NN	NN	_	11	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	development	development	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	A/R	a/r	NN	NN	_	22	compound	_	_
22	tolerance	tolerance	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	22	punct	_	_
24	with	with	IN	IN	_	28	case	_	_
25	respect	respect	NN	NN	_	28	dep	_	_
26	to	to	TO	TO	_	28	case	_	_
27	PMN	pmn	NN	NN	_	28	compound	_	_
28	adhesion	adhesion	NN	NN	_	22	nmod	_	_
29	)	)	-RRB-	-RRB-	_	22	punct	_	_
30	,	,	,	,	_	11	punct	_	_
31	perhaps	perhaps	RB	RB	_	34	advmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	transcriptional	transcriptional	JJ	JJ	_	34	amod	_	_
34	regulation	regulation	NN	NN	_	11	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	GTP-cyclohydrolase	gtp-cyclohydrolase	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	increased	increase	VBN	VBN	_	4	amod	_	_
3	NO	no	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	10	nsubj	_	_
5	during	during	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	second	second	JJ	JJ	_	9	amod	_	_
8	A/R	a/r	NN	NN	_	9	compound	_	_
9	insult	insult	NN	NN	_	4	nmod	_	_
10	reduces	reduce	VBZ	VBZ	_	0	root	_	_
11	PMN	pmn	NN	NN	_	12	compound	_	_
12	adhesion	adhesion	NN	NN	_	10	dobj	_	_
13	most	most	RBS	RBS	_	14	advmod	_	_
14	likely	likely	RB	RB	_	10	advmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	reducing	reduce	VBG	VBG	_	10	advcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	intracellular	intracellular	JJ	JJ	_	20	amod	_	_
19	oxidant	oxidant	JJ	JJ	_	20	amod	_	_
20	stress	stress	NN	NN	_	21	nsubj	_	_
21	induced	induce	VBN	VBN	_	16	dep	_	_
22	by	by	IN	IN	_	23	case	_	_
23	A/R	a/r	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	CD80	cd80	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CD86	cd86	NN	NN	_	1	conj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	equivalent	equivalent	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
9	ability	ability	NN	NN	_	6	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	9	acl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CD28	cd28	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Ligation	ligation	NN	NN	_	21	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	either	either	CC	CC	_	4	cc:preconj	_	_
4	CD80	cd80	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	B7-1	b7-1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	or	or	CC	CC	_	4	cc	_	_
9	CD86	cd86	NN	NN	_	4	conj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	B7-2	b7-2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	4	punct	_	_
14	two	two	CD	CD	_	16	nummod	_	_
15	principal	principal	JJ	JJ	_	16	amod	_	_
16	ligands	ligand	NNS	NNS	_	4	appos	_	_
17	for	for	IN	IN	_	18	case	_	_
18	CD28	cd28	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	thought	think	VBN	VBN	_	0	root	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	skew	skew	VB	VB	_	21	xcomp	_	_
24	the	the	DT	DT	_	26	det	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	response	response	NN	NN	_	23	dobj	_	_
27	toward	toward	IN	IN	_	31	case	_	_
28	Th1	th1	NN	NN	_	31	compound	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	Th2	th2	NN	NN	_	28	conj	_	_
31	differentiation	differentiation	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	early	early	JJ	JJ	_	7	amod	_	_
5	signal	signal	NN	NN	_	7	compound	_	_
6	transduction	transduction	NN	NN	_	7	compound	_	_
7	pathways	pathway	NNS	NNS	_	3	dobj	_	_
8	recruited	recruit	VBN	VBN	_	7	acl	_	_
9	following	follow	VBG	VBG	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	8	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	either	either	CC	CC	_	15	cc:preconj	_	_
15	CD80	cd80	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	CD86	cd86	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Purified	purify	VBN	VBN	_	5	amod	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	11	nsubjpass	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	Jurkat	jurkat	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	conj	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	stimulated	stimulate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	19	case	_	_
13	Chinese	chinese	JJ	JJ	_	15	dep	_	_
14	hamster	hamster	NN	NN	_	15	dep	_	_
15	ovary	ovary	NN	NN	_	19	amod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CHO	cho	NN	NN	_	15	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	expressing	express	VBG	VBG	_	19	acl	_	_
21	either	either	CC	CC	_	23	cc:preconj	_	_
22	human	human	JJ	JJ	_	23	amod	_	_
23	CD80	cd80	NN	NN	_	20	dobj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	CHO-CD80	cho-cd80	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	human	human	JJ	JJ	_	29	amod	_	_
29	CD86	cd86	NN	NN	_	23	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	CHO-CD86	cho-cd86	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	or	or	CC	CC	_	19	cc	_	_
34	with	with	IN	IN	_	37	case	_	_
35	anti-CD28	anti-cd28	JJ	JJ	_	37	amod	_	_
36	monoclonal	monoclonal	JJ	JJ	_	37	amod	_	_
37	antibody	antibody	NN	NN	_	19	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	mAb	mab	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	7	case	_	_
2	the	the	DT	DT	_	7	dep	_	_
3	presence	presence	NN	NN	_	7	dep	_	_
4	of	of	IN	IN	_	7	case	_	_
5	phorbol	phorbol	NN	NN	_	7	compound	_	_
6	12-myristate	12-myristate	NN	NN	_	7	compound	_	_
7	13-acetate	13-acetate	NN	NN	_	19	nmod	_	_
8	,	,	,	,	_	19	punct	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	CHO-CD80	cho-cd80	NN	NN	_	19	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	CHO-CD86	cho-cd86	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	19	punct	_	_
14	like	like	IN	IN	_	16	case	_	_
15	anti-CD28	anti-cd28	JJ	JJ	_	16	amod	_	_
16	mAb	mab	NN	NN	_	19	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	capable	capable	JJ	JJ	_	0	root	_	_
20	of	of	IN	IN	_	21	mark	_	_
21	stimulating	stimulate	VBG	VBG	_	19	advcl	_	_
22	cytokine	cytokine	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	21	dobj	_	_
24	from	from	IN	IN	_	29	case	_	_
25	both	both	CC	CC	_	29	cc:preconj	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	peripheral	peripheral	JJ	JJ	_	29	amod	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	23	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Jurkat	jurkat	NN	NN	_	33	compound	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	19	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	CHO-CD80	cho-cd80	NN	NN	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	CHO-CD86	cho-cd86	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	13	punct	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	dep	_	_
8	presence	presence	NN	NN	_	11	dep	_	_
9	of	of	IN	IN	_	11	case	_	_
10	anti-CD3	anti-cd3	JJ	JJ	_	11	amod	_	_
11	mAb	mab	NN	NN	_	13	nmod	_	_
12	,	,	,	,	_	13	punct	_	_
13	costimulated	costimulate	VBD	VBD	_	0	root	_	_
14	NFAT-dependent	nfat-dependent	JJ	JJ	_	16	amod	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	13	punct	_	_

1	Several	several	JJ	JJ	_	4	amod	_	_
2	intracellular	intracellular	JJ	JJ	_	4	amod	_	_
3	signaling	signal	VBG	VBG	_	4	amod	_	_
4	proteins	protein	NNS	NNS	_	13	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	such	such	JJ	JJ	_	8	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	CBL	cbl	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	VAV	vav	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
14	on	on	IN	IN	_	15	case	_	_
15	tyrosine	tyrosine	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	response	response	NN	NN	_	19	dep	_	_
18	to	to	TO	TO	_	19	case	_	_
19	CD80	cd80	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	CD86	cd86	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	19	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	anti-CD28	anti-cd28	JJ	JJ	_	25	amod	_	_
25	mAb	mab	NN	NN	_	19	conj	_	_
26	.	.	.	.	_	13	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	28	advmod	_	_
2	,	,	,	,	_	28	punct	_	_
3	although	although	IN	IN	_	15	mark	_	_
4	stimulation	stimulation	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	Jurkat	jurkat	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	either	either	CC	CC	_	11	cc:preconj	_	_
11	CHO-CD80	cho-cd80	NN	NN	_	4	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	anti-CD28	anti-cd28	JJ	JJ	_	14	amod	_	_
14	mAb	mab	NN	NN	_	11	conj	_	_
15	resulted	result	VBD	VBD	_	28	advcl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	robust	robust	JJ	JJ	_	19	amod	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CD28	cd28	NN	NN	_	19	nmod	_	_
22	itself	itself	PRP	PRP	_	21	nmod:npmod	_	_
23	,	,	,	,	_	28	punct	_	_
24	ligation	ligation	NN	NN	_	28	nsubj	_	_
25	with	with	IN	IN	_	26	case	_	_
26	CHO-CD86	cho-cd86	NN	NN	_	24	nmod	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	unable	unable	JJ	JJ	_	0	root	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	induce	induce	VB	VB	_	28	xcomp	_	_
31	detectable	detectable	JJ	JJ	_	34	amod	_	_
32	CD28	cd28	NN	NN	_	34	compound	_	_
33	tyrosyl	tyrosyl	NN	NN	_	34	compound	_	_
34	phosphorylation	phosphorylation	NN	NN	_	30	dobj	_	_
35	over	over	IN	IN	_	37	case	_	_
36	a	a	DT	DT	_	37	det	_	_
37	range	range	NN	NN	_	30	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	stimulation	stimulation	NN	NN	_	40	compound	_	_
40	conditions	condition	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	28	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	19	nmod	_	_
3	,	,	,	,	_	19	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	association	association	NN	NN	_	19	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	phosphoinositide	phosphoinositide	NN	NN	_	8	compound	_	_
8	3-kinase	3-kinase	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	CD28	cd28	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	enhanced	enhance	VBN	VBN	_	14	amod	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	5	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	phospholipase	phospholipase	NN	NN	_	17	compound	_	_
17	Cgamma	cgamma	NN	NN	_	14	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	seen	see	VBN	VBN	_	0	root	_	_
20	after	after	IN	IN	_	22	case	_	_
21	anti-CD28	anti-cd28	JJ	JJ	_	22	amod	_	_
22	mAb	mab	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	CHO-CD80	cho-cd80	NN	NN	_	25	compound	_	_
25	stimulation	stimulation	NN	NN	_	22	conj	_	_
26	but	but	CC	CC	_	19	cc	_	_
27	to	to	TO	TO	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	much	much	RB	RB	_	30	advmod	_	_
30	lesser	lesser	JJR	JJR	_	31	amod	_	_
31	extent	extent	NN	NN	_	19	conj	_	_
32	after	after	IN	IN	_	34	case	_	_
33	CHO-CD86	cho-cd86	NN	NN	_	34	compound	_	_
34	stimulation	stimulation	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	19	punct	_	_

1	Thus	thus	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	ligation	ligation	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CD28	cd28	NN	NN	_	3	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	either	either	CC	CC	_	8	cc:preconj	_	_
8	CD80	cd80	NN	NN	_	3	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	CD86	cd86	NN	NN	_	8	conj	_	_
11	leads	lead	VBZ	VBZ	_	0	root	_	_
12	to	to	TO	TO	_	17	case	_	_
13	shared	shared	JJ	JJ	_	17	amod	_	_
14	early	early	JJ	JJ	_	17	amod	_	_
15	signal	signal	NN	NN	_	17	compound	_	_
16	transduction	transduction	NN	NN	_	17	compound	_	_
17	events	event	NNS	NNS	_	11	nmod	_	_
18	such	such	JJ	JJ	_	22	case	_	_
19	as	as	IN	IN	_	18	mwe	_	_
20	the	the	DT	DT	_	22	det	_	_
21	tyrosine	tyrosine	NN	NN	_	22	compound	_	_
22	phosphorylation	phosphorylation	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	CBL	cbl	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	VAV	vav	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	17	punct	_	_
28	to	to	TO	TO	_	31	case	_	_
29	NFAT-mediated	nfat-mediated	JJ	JJ	_	31	amod	_	_
30	transcriptional	transcriptional	JJ	JJ	_	31	amod	_	_
31	activation	activation	NN	NN	_	17	conj	_	_
32	,	,	,	,	_	17	punct	_	_
33	and	and	CC	CC	_	17	cc	_	_
34	to	to	TO	TO	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	costimulation	costimulation	NN	NN	_	17	conj	_	_
37	of	of	IN	IN	_	43	case	_	_
38	interleukin-2	interleukin-2	NN	NN	_	43	compound	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	38	conj	_	_
41	colony-stimulating	colony-stimulating	JJ	JJ	_	43	amod	_	_
42	factor	factor	NN	NN	_	43	compound	_	_
43	production	production	NN	NN	_	36	nmod	_	_
44	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	CD80	cd80	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	CD86	cd86	NN	NN	_	3	conj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	induce	induce	VBP	VBP	_	0	root	_	_
8	distinct	distinct	JJ	JJ	_	11	amod	_	_
9	signal	signal	NN	NN	_	11	compound	_	_
10	transduction	transduction	NN	NN	_	11	compound	_	_
11	pathways	pathway	NNS	NNS	_	7	dobj	_	_
12	including	include	VBG	VBG	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CD28	cd28	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	phospholipase	phospholipase	NN	NN	_	20	compound	_	_
20	Cgamma1	cgamma1	NN	NN	_	17	conj	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	SH2-dependent	sh2-dependent	JJ	JJ	_	24	amod	_	_
24	association	association	NN	NN	_	15	conj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	phosphoinositide	phosphoinositide	NN	NN	_	27	compound	_	_
27	3-kinase	3-kinase	NN	NN	_	24	nmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	CD28	cd28	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	8	det	_	_
2	quantitative	quantitative	JJ	JJ	_	8	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	if	if	IN	IN	_	5	dep	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	qualitative	qualitative	JJ	JJ	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	differences	difference	NNS	NNS	_	19	nsubj	_	_
9	between	between	IN	IN	_	10	case	_	_
10	signaling	signaling	NN	NN	_	8	nmod	_	_
11	initiated	initiate	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	ligands	ligand	NNS	NNS	_	11	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	CD28	cd28	NN	NN	_	15	nmod	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	contribute	contribute	VB	VB	_	0	root	_	_
20	to	to	TO	TO	_	22	case	_	_
21	functional	functional	JJ	JJ	_	22	amod	_	_
22	differences	difference	NNS	NNS	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	22	punct	_	_
24	e.g.	e.g.	FW	FW	_	28	dep	_	_
25	Th1	th1	NN	NN	_	28	compound	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	Th2	th2	NN	NN	_	25	conj	_	_
28	differentiation	differentiation	NN	NN	_	22	nmod	_	_
29	)	)	-RRB-	-RRB-	_	22	punct	_	_
30	in	in	IN	IN	_	33	case	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	responses	response	NNS	NNS	_	22	nmod	_	_
34	.	.	.	.	_	19	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Egr-2	egr-2	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	5	case	_	_
5	up-regulation	up-regulation	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Fas	fas	NN	NN	_	8	compound	_	_
8	ligand	ligand	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	normal	normal	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	aberrant	aberrant	JJ	JJ	_	16	amod	_	_
15	double-negative	double-negative	JJ	JJ	_	16	amod	_	_
16	lpr	lpr	NN	NN	_	12	conj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	gld	gld	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	Fas	fas	NN	NN	_	8	compound	_	_
6	ligand	ligand	NN	NN	_	8	compound	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	element	element	NN	NN	_	3	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	FLRE	flre	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	Fas	fas	NN	NN	_	19	compound	_	_
15	ligand	ligand	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	fasL	fasl	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	promoter	promoter	NN	NN	_	8	nmod	_	_
20	that	that	IN	IN	_	21	nsubj	_	_
21	binds	bind	VBZ	VBZ	_	8	acl:relcl	_	_
22	Egr	egr	NN	NN	_	24	compound	_	_
23	family	family	NN	NN	_	24	compound	_	_
24	proteins	protein	NNS	NNS	_	21	dobj	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	demonstrated	demonstrate	VBD	VBD	_	3	conj	_	_
27	that	that	IN	IN	_	45	mark	_	_
28	Egr-3	egr-3	NN	NN	_	45	nsubj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PILOT	pilot	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	but	but	CC	CC	_	33	cc	_	_
33	not	not	RB	RB	_	28	cc	_	_
34	Egr-1	egr-1	NN	NN	_	28	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	NGFI-A	ngfi-a	NN	NN	_	34	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	Krox-24	krox-24	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	Tis-8	tis-8	NN	NN	_	36	conj	_	_
41	,	,	,	,	_	36	punct	_	_
42	and	and	CC	CC	_	36	cc	_	_
43	Zif-268	zif-268	NN	NN	_	36	conj	_	_
44	)	)	-RRB-	-RRB-	_	36	punct	_	_
45	induces	induce	VBZ	VBZ	_	26	ccomp	_	_
46	transcription	transcription	NN	NN	_	45	dobj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	fasL	fasl	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	aberrant	aberrant	JJ	JJ	_	6	amod	_	_
3	CD4(-)	cd4(-)	JJ	JJ	_	6	amod	_	_
4	CD8(-)	cd8(-)	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	26	nsubj	_	_
7	from	from	IN	IN	_	11	case	_	_
8	lpr/lpr	lpr/lpr	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	gld/gld	gld/gld	NN	NN	_	8	conj	_	_
11	mice	mouse	NNS	NNS	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	have	have	VBP	VBP	_	11	acl:relcl	_	_
15	mutations	mutation	NNS	NNS	_	14	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	genes	gene	NNS	NNS	_	14	nmod	_	_
19	encoding	encode	VBG	VBG	_	20	case	_	_
20	Fas	fas	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	FasL	fasl	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	14	punct	_	_
24	respectively	respectively	RB	RB	_	14	advmod	_	_
25	,	,	,	,	_	11	punct	_	_
26	have	have	VBP	VBP	_	0	root	_	_
27	an	a	DT	DT	_	29	det	_	_
28	activated	activate	VBN	VBN	_	29	amod	_	_
29	phenotype	phenotype	NN	NN	_	26	dobj	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	constitutively	constitutively	RB	RB	_	32	advmod	_	_
32	express	express	VBP	VBP	_	26	conj	_	_
33	high	high	JJ	JJ	_	34	amod	_	_
34	levels	level	NNS	NNS	_	32	dobj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	fasL	fasl	NN	NN	_	37	compound	_	_
37	mRNA	mrna	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	26	punct	_	_
39	prompting	prompt	VBG	VBG	_	26	advcl	_	_
40	us	we	PRP	PRP	_	39	dobj	_	_
41	to	to	TO	TO	_	42	mark	_	_
42	ask	ask	VB	VB	_	39	xcomp	_	_
43	what	what	WP	WP	_	44	det	_	_
44	role	role	NN	NN	_	53	dobj	_	_
45	if	if	IN	IN	_	46	mark	_	_
46	any	any	DT	DT	_	53	advcl	_	_
47	the	the	DT	DT	_	48	det	_	_
48	FLRE	flre	NN	NN	_	53	nsubj	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	Egr	egr	NN	NN	_	52	compound	_	_
51	family	family	NN	NN	_	52	compound	_	_
52	proteins	protein	NNS	NNS	_	48	conj	_	_
53	have	have	VBP	VBP	_	42	ccomp	_	_
54	in	in	IN	IN	_	57	case	_	_
55	this	this	DT	DT	_	57	det	_	_
56	aberrant	aberrant	JJ	JJ	_	57	amod	_	_
57	expression	expression	NN	NN	_	53	nmod	_	_
58	of	of	IN	IN	_	59	case	_	_
59	fasL	fasl	NN	NN	_	57	nmod	_	_
60	.	.	.	.	_	26	punct	_	_

1	Unstimulated	unstimulated	JJ	JJ	_	8	amod	_	_
2	MRL-lpr/lpr	mrl-lpr/lpr	NN	NN	_	8	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	C3H-gld/gld	c3h-gld/gld	JJ	JJ	_	2	conj	_	_
5	CD4(-)	cd4(-)	JJ	JJ	_	8	amod	_	_
6	CD8(-)	cd8(-)	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	10	nsubj	_	_
9	constitutively	constitutively	RB	RB	_	10	advmod	_	_
10	contained	contain	VBD	VBD	_	0	root	_	_
11	high	high	JJ	JJ	_	12	amod	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	proteins	protein	NNS	NNS	_	12	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	bound	bind	VBD	VBD	_	15	acl:relcl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	FLRE	flre	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Supershift	supershift	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	these	these	DT	DT	_	5	det	_	_
5	proteins	protein	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	Egr-1	egr-1	NN	NN	_	3	xcomp	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Egr-2	egr-2	NN	NN	_	8	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Krox-20	krox-20	NN	NN	_	8	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	;	;	:	:	_	3	punct	_	_
15	Egr-3	egr-3	NN	NN	_	18	nsubjpass	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	detected	detect	VBN	VBN	_	3	parataxis	_	_
19	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	normal	normal	JJ	JJ	_	6	amod	_	_
4	lymph	lymph	NN	NN	_	6	compound	_	_
5	node	node	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Egr-1	egr-1	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	-2	-2	CD	CD	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	-3	-3	CD	CD	_	12	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	with	with	IN	IN	_	3	case	_	_
3	egr-3	egr-3	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	expression	expression	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	egr-2	egr-2	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	overexpressed	overexpress	VBN	VBN	_	3	amod	_	_
3	Egr-1	egr-1	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	ineffective	ineffective	JJ	JJ	_	11	advcl	_	_
6	,	,	,	,	_	11	punct	_	_
7	overexpressed	overexpress	VBN	VBN	_	8	amod	_	_
8	Egr-2	egr-2	NN	NN	_	11	nsubj	_	_
9	was	be	VBD	VBD	_	11	cop	_	_
10	as	as	RB	RB	_	11	advmod	_	_
11	potent	potent	JJ	JJ	_	0	root	_	_
12	as	as	IN	IN	_	13	case	_	_
13	Egr-3	egr-3	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	11	advcl	_	_
16	fasL	fasl	NN	NN	_	19	compound	_	_
17	promoter-dependent	promoter-dependent	JJ	JJ	_	19	amod	_	_
18	reporter	reporter	NN	NN	_	19	compound	_	_
19	constructs	construct	NNS	NNS	_	15	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	T	t	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	hybridomas	hybridoma	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	HeLa	hela	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	conj	_	_
27	,	,	,	,	_	11	punct	_	_
28	and	and	CC	CC	_	11	cc	_	_
29	both	both	DT	DT	_	30	nsubj	_	_
30	up-regulated	up-regulate	VBN	VBN	_	11	conj	_	_
31	endogenous	endogenous	JJ	JJ	_	33	amod	_	_
32	fasL	fasl	NN	NN	_	33	compound	_	_
33	mRNA	mrna	NN	NN	_	30	dobj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	HeLa	hela	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	11	punct	_	_

1	FasL-dependent	fasl-dependent	JJ	JJ	_	3	amod	_	_
2	reporter	reporter	NN	NN	_	3	compound	_	_
3	constructs	construct	NNS	NNS	_	14	nsubj	_	_
4	in	in	IN	IN	_	11	case	_	_
5	MRL-lpr/lpr	mrl-lpr/lpr	NN	NN	_	11	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	C3H-gld/gld	c3h-gld/gld	JJ	JJ	_	5	conj	_	_
8	CD4(-)	cd4(-)	JJ	JJ	_	11	amod	_	_
9	CD8(-)	cd8(-)	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	were	be	VBD	VBD	_	14	cop	_	_
13	constitutively	constitutively	RB	RB	_	14	advmod	_	_
14	active	active	JJ	JJ	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	this	this	DT	DT	_	18	det	_	_
18	activity	activity	NN	NN	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	largely	largely	RB	RB	_	21	advmod	_	_
21	prevented	prevent	VBN	VBN	_	14	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	mutation	mutation	NN	NN	_	21	nmod	_	_
24	of	of	IN	IN	_	30	case	_	_
25	the	the	DT	DT	_	30	det	_	_
26	critical	critical	JJ	JJ	_	30	amod	_	_
27	Egr	egr	NN	NN	_	30	compound	_	_
28	family	family	NN	NN	_	30	compound	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	element	element	NN	NN	_	23	nmod	_	_
31	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	Egr-2	egr-2	NN	NN	_	10	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	3	cc	_	_
6	addition	addition	NN	NN	_	5	dep	_	_
7	to	to	TO	TO	_	5	dep	_	_
8	Egr-3	egr-3	NN	NN	_	3	conj	_	_
9	,	,	,	,	_	3	punct	_	_
10	regulates	regulate	VBZ	VBZ	_	0	root	_	_
11	FasL	fasl	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	activated	activate	VBN	VBN	_	17	amod	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	Egr-2	egr-2	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	likely	likely	JJ	JJ	_	10	conj	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	play	play	VB	VB	_	22	xcomp	_	_
25	a	a	DT	DT	_	27	det	_	_
26	direct	direct	JJ	JJ	_	27	amod	_	_
27	role	role	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	aberrant	aberrant	NN	NN	_	31	compound	_	_
30	fasL	fasl	NN	NN	_	31	compound	_	_
31	up-regulation	up-regulation	NN	NN	_	24	nmod	_	_
32	in	in	IN	IN	_	39	case	_	_
33	lpr/lpr	lpr/lpr	NN	NN	_	39	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	gld/gld	gld/gld	NN	NN	_	33	conj	_	_
36	CD4(-)	cd4(-)	JJ	JJ	_	39	amod	_	_
37	CD8(-)	cd8(-)	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	31	nmod	_	_
40	.	.	.	.	_	10	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	mitogen-activated	mitogen-activated	JJ	JJ	_	6	amod	_	_
4	protein	protein	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	pathways	pathway	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	interleukin-8	interleukin-8	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	1	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	polymorphonuclear	polymorphonuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	stimulated	stimulate	VBN	VBN	_	12	acl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	lipopolysaccharide	lipopolysaccharide	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	Mycoplasma	mycoplasma	NN	NN	_	23	compound	_	_
21	fermentans	fermentan	NNS	NNS	_	23	compound	_	_
22	membrane	membrane	NN	NN	_	23	compound	_	_
23	lipoproteins	lipoprotein	NNS	NNS	_	18	conj	_	_
24	.	.	.	.	_	1	punct	_	_

1	Interleukin-8	interleukin-8	NN	NN	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-8	il-8	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	a	a	DT	DT	_	7	det	_	_
7	chemokine	chemokine	NN	NN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	belongs	belong	VBZ	VBZ	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	alpha-chemokine	alpha-chemokine	NN	NN	_	9	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	CXC	cxc	NN	NN	_	15	compound	_	_
15	subfamily	subfamily	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	produced	produce	VBN	VBN	_	9	conj	_	_
19	by	by	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	wide	wide	JJ	JJ	_	22	amod	_	_
22	variety	variety	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	including	include	VBG	VBG	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	polymorphonuclear	polymorphonuclear	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	PMN	pmn	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	7	punct	_	_

1	IL-8	il-8	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	secreted	secrete	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	response	response	NN	NN	_	8	dep	_	_
6	to	to	TO	TO	_	8	case	_	_
7	inflammatory	inflammatory	JJ	JJ	_	8	amod	_	_
8	stimuli	stimulus	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	notably	notably	RB	RB	_	12	advmod	_	_
11	bacterial	bacterial	JJ	JJ	_	12	amod	_	_
12	products	product	NNS	NNS	_	8	appos	_	_
13	such	such	JJ	JJ	_	15	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	lipopolysaccharide	lipopolysaccharide	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LPS	lps	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	3	punct	_	_
20	but	but	CC	CC	_	3	cc	_	_
21	little	little	JJ	JJ	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	known	know	VBN	VBN	_	3	conj	_	_
24	about	about	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	mechanisms	mechanism	NNS	NNS	_	23	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	which	which	WDT	WDT	_	31	nmod	_	_
29	these	these	DT	DT	_	30	det	_	_
30	agents	agent	NNS	NNS	_	31	nsubj	_	_
31	mediate	mediate	VBP	VBP	_	26	acl:relcl	_	_
32	IL-8	il-8	NN	NN	_	33	compound	_	_
33	induction	induction	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	Mycoplasma	mycoplasma	NN	NN	_	12	compound	_	_
9	fermentans	fermentan	NNS	NNS	_	12	compound	_	_
10	lipid-associated	lipid-associated	JJ	JJ	_	12	amod	_	_
11	membrane	membrane	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	16	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	LAMPf	lampf	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	induce	induce	VBP	VBP	_	6	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	production	production	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	high	high	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-8	il-8	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	30	case	_	_
25	THP-1	thp-1	NN	NN	_	30	compound	_	_
26	(	(	-LRB-	-LRB-	_	30	punct	_	_
27	human	human	JJ	JJ	_	30	amod	_	_
28	monocyte	monocyte	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	cells	cell	NNS	NNS	_	18	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	PMN	pmn	NN	NN	_	30	conj	_	_
33	at	at	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	same	same	JJ	JJ	_	36	amod	_	_
36	extent	extent	NN	NN	_	16	nmod	_	_
37	as	as	IN	IN	_	38	case	_	_
38	LPS	lps	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	stimulation	stimulation	NN	NN	_	15	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	monocytic	monocytic	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	either	either	CC	CC	_	12	cc:preconj	_	_
12	LPS	lps	NN	NN	_	6	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	LAMPf	lampf	NN	NN	_	12	conj	_	_
15	led	lead	VBD	VBD	_	4	ccomp	_	_
16	to	to	TO	TO	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	series	series	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	common	common	JJ	JJ	_	23	amod	_	_
21	downstream	downstream	JJ	JJ	_	23	amod	_	_
22	signaling	signaling	NN	NN	_	23	compound	_	_
23	events	event	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	including	include	VBG	VBG	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	protein	protein	NN	NN	_	31	compound	_	_
30	tyrosine	tyrosine	NN	NN	_	31	compound	_	_
31	kinase	kinase	NN	NN	_	27	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	of	of	IN	IN	_	37	case	_	_
34	mitogen-activated	mitogen-activated	JJ	JJ	_	37	amod	_	_
35	protein	protein	NN	NN	_	37	compound	_	_
36	kinase	kinase	NN	NN	_	37	compound	_	_
37	cascades	cascade	NNS	NNS	_	31	conj	_	_
38	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	28	advcl	_	_
3	PD-98059	pd-98059	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	SB203580	sb203580	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	two	two	CD	CD	_	11	nummod	_	_
8	potent	potent	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	selective	selective	JJ	JJ	_	8	conj	_	_
11	inhibitors	inhibitor	NNS	NNS	_	3	appos	_	_
12	of	of	IN	IN	_	13	case	_	_
13	MEK1	mek1	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	kinase	kinase	NN	NN	_	13	dep	_	_
17	upstream	upstream	RB	RB	_	16	advmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	ERK1/2	erk1/2	NN	NN	_	17	nmod	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	and	and	CC	CC	_	13	cc	_	_
22	p38	p38	NN	NN	_	13	conj	_	_
23	,	,	,	,	_	3	punct	_	_
24	respectively	respectively	RB	RB	_	2	advmod	_	_
25	,	,	,	,	_	28	punct	_	_
26	we	we	PRP	PRP	_	28	nsubj	_	_
27	have	have	VBP	VBP	_	28	aux	_	_
28	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
29	that	that	IN	IN	_	35	mark	_	_
30	both	both	CC	CC	_	31	cc:preconj	_	_
31	ERK1/2	erk1/2	NN	NN	_	35	nsubj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	p38	p38	NN	NN	_	34	compound	_	_
34	cascades	cascade	NNS	NNS	_	31	conj	_	_
35	play	play	VBP	VBP	_	28	ccomp	_	_
36	a	a	DT	DT	_	38	det	_	_
37	key	key	JJ	JJ	_	38	amod	_	_
38	role	role	NN	NN	_	35	dobj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	production	production	NN	NN	_	35	nmod	_	_
42	of	of	IN	IN	_	43	case	_	_
43	IL-8	il-8	NN	NN	_	41	nmod	_	_
44	by	by	IN	IN	_	45	case	_	_
45	monocytes	monocyte	NNS	NNS	_	41	nmod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	PMN	pmn	NN	NN	_	45	conj	_	_
48	stimulated	stimulate	VBN	VBN	_	45	acl	_	_
49	with	with	IN	IN	_	51	case	_	_
50	bacterial	bacterial	JJ	JJ	_	51	amod	_	_
51	fractions	fraction	NNS	NNS	_	48	nmod	_	_
52	.	.	.	.	_	28	punct	_	_

1	Protective	protective	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	notch-1	notch-1	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	TCR-induced	tcr-induced	JJ	JJ	_	7	amod	_	_
7	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	Notch	notch	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	originally	originally	RB	RB	_	7	advmod	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	Drosophila	drosophila	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	known	know	VBN	VBN	_	7	conj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	mediate	mediate	VB	VB	_	12	xcomp	_	_
15	cell	cell	NN	NN	_	18	compound	_	_
16	to	to	TO	TO	_	15	dep	_	_
17	cell	cell	NN	NN	_	15	dep	_	_
18	communication	communication	NN	NN	_	14	dobj	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	influence	influence	VB	VB	_	14	conj	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	fate	fate	NN	NN	_	23	compound	_	_
23	decisions	decision	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	7	punct	_	_

1	Members	member	NNS	NNS	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	family	family	NN	NN	_	1	nmod	_	_
5	have	have	VBP	VBP	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	isolated	isolate	VBN	VBN	_	0	root	_	_
8	from	from	IN	IN	_	9	case	_	_
9	invertebrates	invertebrate	NNS	NNS	_	7	nmod	_	_
10	as	as	RB	RB	_	9	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	vertebrates	vertebrate	NNS	NNS	_	9	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	isolated	isolate	VBD	VBD	_	0	root	_	_
3	mouse	mouse	NN	NN	_	4	compound	_	_
4	Notch-1	notch-1	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	yeast	yeast	NN	NN	_	9	compound	_	_
8	two-hybrid	two-hybrid	JJ	JJ	_	9	amod	_	_
9	screen	screen	NN	NN	_	4	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	Nur77	nur77	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	protein	protein	NN	NN	_	11	acl:relcl	_	_
17	that	that	WDT	WDT	_	20	nsubjpass	_	_
18	has	have	VBZ	VBZ	_	20	aux	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	shown	show	VBN	VBN	_	16	acl:relcl	_	_
21	previously	previously	RB	RB	_	20	advmod	_	_
22	to	to	TO	TO	_	24	mark	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	20	xcomp	_	_
25	for	for	IN	IN	_	26	case	_	_
26	apoptosis	apoptosis	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	T	t	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	lines	line	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	presented	present	VBN	VBN	_	2	acl	_	_
4	below	below	IN	IN	_	3	advmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	Notch-1	notch-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	9	nsubj	_	_
9	provides	provide	VBZ	VBZ	_	5	ccomp	_	_
10	significant	significant	JJ	JJ	_	11	amod	_	_
11	protection	protection	NN	NN	_	9	dobj	_	_
12	to	to	TO	TO	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	9	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	TCR-mediated	tcr-mediated	JJ	JJ	_	18	amod	_	_
18	apoptosis	apoptosis	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	new	new	JJ	JJ	_	7	amod	_	_
6	antiapoptotic	antiapoptotic	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	3	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	Notch-1	notch-1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	providing	provide	VBG	VBG	_	3	advcl	_	_
12	evidence	evidence	NN	NN	_	11	dobj	_	_
13	that	that	IN	IN	_	25	mark	_	_
14	,	,	,	,	_	25	punct	_	_
15	in	in	IN	IN	_	18	case	_	_
16	addition	addition	NN	NN	_	18	dep	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	regulating	regulate	VBG	VBG	_	25	advcl	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	fate	fate	NN	NN	_	21	compound	_	_
21	decisions	decision	NNS	NNS	_	18	dobj	_	_
22	,	,	,	,	_	25	punct	_	_
23	Notch-1	notch-1	NN	NN	_	25	nsubj	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	play	play	VB	VB	_	12	ccomp	_	_
26	a	a	DT	DT	_	28	det	_	_
27	critical	critical	JJ	JJ	_	28	amod	_	_
28	role	role	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	30	mark	_	_
30	controlling	control	VBG	VBG	_	25	advcl	_	_
31	levels	level	NNS	NNS	_	30	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	death	death	NN	NN	_	31	nmod	_	_
35	in	in	IN	IN	_	37	case	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	priming	priming	NN	NN	_	4	nsubj	_	_
4	enhances	enhance	VBZ	VBZ	_	0	root	_	_
5	IL-4	il-4	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	increasing	increase	VBG	VBG	_	4	advcl	_	_
10	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	of	of	IN	IN	_	15	amod	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	repetitive	repetitive	JJ	JJ	_	3	amod	_	_
3	activation	activation	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	priming	priming	NN	NN	_	3	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	enhances	enhance	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	many	many	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	such	such	JJ	JJ	_	19	case	_	_
18	as	as	IN	IN	_	17	mwe	_	_
19	IL-4	il-4	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	but	but	CC	CC	_	22	cc	_	_
22	not	not	RB	RB	_	15	cc	_	_
23	others	other	NNS	NNS	_	15	conj	_	_
24	,	,	,	,	_	23	punct	_	_
25	such	such	JJ	JJ	_	27	case	_	_
26	as	as	IN	IN	_	25	mwe	_	_
27	IL-2	il-2	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	11	nsubj	_	_
3	underlying	underlie	VBG	VBG	_	2	acl	_	_
4	selective	selective	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
8	by	by	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	remain	remain	VBP	VBP	_	0	root	_	_
12	poorly	poorly	RB	RB	_	13	advmod	_	_
13	understood	understand	VBN	VBN	_	11	xcomp	_	_
14	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	priming	priming	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	CD4	cd4	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	selectively	selectively	RB	RB	_	11	advmod	_	_
11	enhances	enhance	VBZ	VBZ	_	3	ccomp	_	_
12	IL-4	il-4	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	relative	relative	JJ	JJ	_	17	case	_	_
15	to	to	TO	TO	_	17	case	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	11	nmod	_	_
18	by	by	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	mechanism	mechanism	NN	NN	_	11	nmod	_	_
22	involving	involve	VBG	VBG	_	21	acl	_	_
23	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
24	factor	factor	NN	NN	_	32	compound	_	_
25	of	of	IN	IN	_	32	amod	_	_
26	activated	activate	VBN	VBN	_	32	amod	_	_
27	T	t	NN	NN	_	32	compound	_	_
28	cells	cell	NNS	NNS	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	NFAT	nfat	NN	NN	_	32	compound	_	_
31	)	)	-RRB-	-RRB-	_	32	punct	_	_
32	proteins	protein	NNS	NNS	_	22	dobj	_	_
33	.	.	.	.	_	3	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	detected	detect	VBN	VBN	_	10	advcl	_	_
3	by	by	IN	IN	_	6	case	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vivo	vivo	FW	FW	_	4	dep	_	_
6	footprinting	footprinting	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	priming	priming	NN	NN	_	10	nsubj	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	increases	increase	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	activation-dependent	activation-dependent	JJ	JJ	_	13	amod	_	_
13	engagement	engagement	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	P0	p0	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	P1	p1	NN	NN	_	20	compound	_	_
19	NFAT-binding	nfat-binding	JJ	JJ	_	20	amod	_	_
20	elements	element	NNS	NNS	_	16	conj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IL-4	il-4	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	16	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	Moreover	moreover	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	each	each	DT	DT	_	6	det	_	_
4	proximal	proximal	JJ	JJ	_	6	amod	_	_
5	P	p	NN	NN	_	6	compound	_	_
6	element	element	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	essential	essential	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	13	case	_	_
10	optimal	optimal	JJ	JJ	_	13	amod	_	_
11	IL-4	il-4	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Activated	activate	VBN	VBN	_	5	amod	_	_
2	primed	prime	VBN	VBN	_	5	amod	_	_
3	CD4	cd4	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	6	nsubj	_	_
6	contain	contain	VBP	VBP	_	0	root	_	_
7	more	more	JJR	JJR	_	8	amod	_	_
8	NFAT1	nfat1	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	support	support	VBP	VBP	_	6	conj	_	_
11	greater	greater	JJR	JJR	_	13	amod	_	_
12	NFAT-directed	nfat-directed	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	10	dobj	_	_
14	than	than	IN	IN	_	18	case	_	_
15	unprimed	unprimed	JJ	JJ	_	18	amod	_	_
16	CD4	cd4	NN	NN	_	18	compound	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	6	nmod	_	_
19	,	,	,	,	_	6	punct	_	_
20	while	while	IN	IN	_	35	mark	_	_
21	activator	activator	NN	NN	_	24	dep	_	_
22	protein	protein	NN	NN	_	24	dep	_	_
23	1	1	CD	CD	_	24	compound	_	_
24	binding	binding	NN	NN	_	29	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	activator	activator	NN	NN	_	28	nmod:npmod	_	_
27	protein	protein	NN	NN	_	28	nmod:npmod	_	_
28	1-mediated	1-mediated	JJ	JJ	_	24	conj	_	_
29	transcription	transcription	NN	NN	_	35	nsubj	_	_
30	by	by	IN	IN	_	33	case	_	_
31	both	both	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	types	type	NNS	NNS	_	29	nmod	_	_
34	is	be	VBZ	VBZ	_	35	cop	_	_
35	similar	similar	JJ	JJ	_	6	advcl	_	_
36	.	.	.	.	_	6	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	wild-type	wild-type	JJ	JJ	_	5	amod	_	_
5	NFAT1	nfat1	NN	NN	_	2	nmod	_	_
6	substantially	substantially	RB	RB	_	7	advmod	_	_
7	increases	increase	VBZ	VBZ	_	0	root	_	_
8	IL-4	il-4	NN	NN	_	10	compound	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	15	case	_	_
12	unprimed	unprimed	JJ	JJ	_	15	amod	_	_
13	CD4	cd4	NN	NN	_	15	compound	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	suggesting	suggest	VBG	VBG	_	7	advcl	_	_
18	NFAT1	nfat1	NN	NN	_	21	nsubj	_	_
19	may	may	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	cop	_	_
21	limiting	limit	VBG	VBG	_	17	ccomp	_	_
22	for	for	IN	IN	_	25	case	_	_
23	IL-4	il-4	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	this	this	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	type	type	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	truncated	truncated	JJ	JJ	_	5	amod	_	_
5	form	form	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NFAT1	nfat1	NN	NN	_	5	nmod	_	_
8	acts	act	VBZ	VBZ	_	0	root	_	_
9	as	as	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	dominant-negative	dominant-negative	JJ	JJ	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	reducing	reduce	VBG	VBG	_	8	ccomp	_	_
14	IL-4	il-4	NN	NN	_	16	compound	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	primed	prime	VBN	VBN	_	21	amod	_	_
19	CD4	cd4	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	confirming	confirm	VBG	VBG	_	13	conj	_	_
24	the	the	DT	DT	_	25	det	_	_
25	importance	importance	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	endogenous	endogenous	JJ	JJ	_	28	amod	_	_
28	NFAT	nfat	NN	NN	_	25	nmod	_	_
29	to	to	TO	TO	_	33	case	_	_
30	increased	increase	VBN	VBN	_	33	amod	_	_
31	IL-4	il-4	NN	NN	_	33	compound	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	25	nmod	_	_
34	by	by	IN	IN	_	37	case	_	_
35	effector	effector	NN	NN	_	37	compound	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	NFAT1	nfat1	NN	NN	_	2	nsubj	_	_
2	appears	appear	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	9	mark	_	_
4	be	be	VB	VB	_	9	cop	_	_
5	the	the	DT	DT	_	9	det	_	_
6	major	major	JJ	JJ	_	9	amod	_	_
7	NFAT	nfat	NN	NN	_	9	compound	_	_
8	family	family	NN	NN	_	9	compound	_	_
9	member	member	NN	NN	_	2	xcomp	_	_
10	responsible	responsible	JJ	JJ	_	9	amod	_	_
11	for	for	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	initial	initial	JJ	JJ	_	15	amod	_	_
14	increased	increase	VBN	VBN	_	15	amod	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IL-4	il-4	NN	NN	_	15	nmod	_	_
18	by	by	IN	IN	_	22	case	_	_
19	primed	prime	VBN	VBN	_	22	amod	_	_
20	CD4	cd4	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Requirement	requirement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	GATA-1	gata-1	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	p45	p45	NN	NN	_	3	conj	_	_
6	NF-E2	nf-e2	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	butyric	butyric	JJ	JJ	_	10	amod	_	_
10	acid-induced	acid-induced	JJ	JJ	_	12	amod	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Butyric	butyric	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	BA	ba	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	induce	induce	VB	VB	_	7	xcomp	_	_
10	overexpression	overexpression	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	fetal	fetal	JJ	JJ	_	13	amod	_	_
13	hemoglobin	hemoglobin	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	then	then	RB	RB	_	17	advmod	_	_
16	erythroid	erythroid	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	10	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	BA	ba	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	currently	currently	RB	RB	_	8	advmod	_	_
6	under	under	IN	IN	_	8	case	_	_
7	clinical	clinical	JJ	JJ	_	8	amod	_	_
8	investigation	investigation	NN	NN	_	0	root	_	_
9	as	as	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	potential	potential	JJ	JJ	_	12	amod	_	_
12	therapy	therapy	NN	NN	_	8	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	treatment	treatment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	sickle	sickle	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	disease	disease	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	cancer	cancer	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	8	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	10	nsubj	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	BA-induced	ba-induced	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	remain	remain	VBP	VBP	_	0	root	_	_
11	largely	largely	RB	RB	_	12	advmod	_	_
12	unknown	unknown	JJ	JJ	_	10	xcomp	_	_
13	.	.	.	.	_	10	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	BA-induced	ba-induced	JJ	JJ	_	7	amod	_	_
7	overexpression	overexpression	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
10	genes	gene	NNS	NNS	_	7	nmod	_	_
11	occurred	occur	VBD	VBD	_	4	ccomp	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	involvement	involvement	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	erythroid	erythroid	JJ	JJ	_	23	amod	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	intend	intend	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	demonstrate	demonstrate	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	requirement	requirement	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	GATA-1	gata-1	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-E2	nf-e2	NN	NN	_	10	conj	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	8	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	BA-induced	ba-induced	JJ	JJ	_	19	amod	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	8	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
23	K562	k562	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Time-course	time-course	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	13	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	GATA-1	gata-1	NN	NN	_	12	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	p45	p45	NN	NN	_	8	conj	_	_
11	NF-E2	nf-e2	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	6	nmod	_	_
13	increased	increase	VBD	VBD	_	3	ccomp	_	_
14	during	during	IN	IN	_	16	case	_	_
15	BA	ba	NN	NN	_	16	compound	_	_
16	treatment	treatment	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	antisense	antisense	JJ	JJ	_	4	amod	_	_
4	oligodeoxynucleotides	oligodeoxynucleotide	NNS	NNS	_	12	nsubj	_	_
5	targeting	target	VBG	VBG	_	4	acl	_	_
6	either	either	CC	CC	_	7	cc:preconj	_	_
7	GATA-1	gata-1	NN	NN	_	5	dobj	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	p45	p45	NN	NN	_	11	compound	_	_
10	NF-E2	nf-e2	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	7	conj	_	_
12	inhibited	inhibit	VBD	VBD	_	0	root	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	BA-induced	ba-induced	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	BA-induced	ba-induced	JJ	JJ	_	7	amod	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	growth	growth	NN	NN	_	7	compound	_	_
7	inhibition	inhibition	NN	NN	_	10	nsubjpass	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	affected	affect	VBN	VBN	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	first	first	JJ	JJ	_	7	amod	_	_
6	direct	direct	JJ	JJ	_	7	amod	_	_
7	evidence	evidence	NN	NN	_	3	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	requirement	requirement	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	GATA-1	gata-1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-E2	nf-e2	NN	NN	_	12	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	BA-induced	ba-induced	JJ	JJ	_	18	amod	_	_
17	differentiation	differentiation	NN	NN	_	18	compound	_	_
18	process	process	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	1	nmod	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	8	advmod	_	_
8	and	and	CC	CC	_	1	advmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vivo	vivo	FW	FW	_	8	advmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	role	role	NN	NN	_	1	dep	_	_
13	of	of	IN	IN	_	15	case	_	_
14	26S	26s	NN	NN	_	15	compound	_	_
15	proteasome	proteasome	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	aux	_	_
3	becoming	become	VBG	VBG	_	0	root	_	_
4	increasingly	increasingly	RB	RB	_	5	advmod	_	_
5	apparent	apparent	JJ	JJ	_	3	xcomp	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	9	nsubj	_	_
9	plays	play	VBZ	VBZ	_	3	ccomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	critical	critical	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	regulating	regulate	VBG	VBG	_	12	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	14	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Data	datum	NNS	NNS	_	8	nsubj	_	_
2	obtained	obtain	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	4	case	_	_
4	studies	study	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
7	laboratories	laboratory	NNS	NNS	_	4	nmod	_	_
8	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
9	that	that	IN	IN	_	12	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	proteasome	proteasome	NN	NN	_	12	nsubj	_	_
12	plays	play	VBZ	VBZ	_	8	ccomp	_	_
13	an	a	DT	DT	_	15	det	_	_
14	important	important	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	inflammatory	inflammatory	JJ	JJ	_	19	amod	_	_
19	cascade	cascade	NN	NN	_	12	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	regulating	regulate	VBG	VBG	_	12	advcl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activation	activation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NF-kappa	nf-kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Indeed	indeed	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	availability	availability	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	selective	selective	JJ	JJ	_	11	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	orally	orally	RB	RB	_	9	advmod	_	_
9	active	active	JJ	JJ	_	6	conj	_	_
10	proteasome	proteasome	NN	NN	_	11	compound	_	_
11	inhibitors	inhibitor	NNS	NNS	_	4	nmod	_	_
12	should	should	MD	MD	_	13	aux	_	_
13	prove	prove	VB	VB	_	0	root	_	_
14	useful	useful	JJ	JJ	_	13	xcomp	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	delineating	delineate	VBG	VBG	_	13	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	roles	role	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	proteasome	proteasome	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	21	conj	_	_
25	in	in	IN	IN	_	28	case	_	_
26	other	other	JJ	JJ	_	28	amod	_	_
27	pathophysiological	pathophysiological	JJ	JJ	_	28	amod	_	_
28	conditions	condition	NNS	NNS	_	18	nmod	_	_
29	such	such	JJ	JJ	_	31	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	cancer	cancer	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	heart	heart	NN	NN	_	34	compound	_	_
34	disease	disease	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	13	punct	_	_

1	Imbalanced	imbalanced	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	isoforms	isoform	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cultured	culture	VBN	VBN	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	patient	patient	NN	NN	_	10	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	systemic	systemic	JJ	JJ	_	17	amod	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	resistance	resistance	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	chronic	chronic	JJ	JJ	_	21	amod	_	_
20	lymphocytic	lymphocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	receptor	receptor	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GR	gr	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	14	case	_	_
11	two	two	CD	CD	_	14	nummod	_	_
12	alternatively	alternatively	RB	RB	_	13	advmod	_	_
13	spliced	splice	VBN	VBN	_	14	amod	_	_
14	isoforms	isoform	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	GRalpha	gralpha	NN	NN	_	14	appos	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	GRbeta	grbeta	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Whereas	whereas	IN	IN	_	7	mark	_	_
2	GRalpha	gralpha	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	a	a	DT	DT	_	7	det	_	_
5	hormone-activated	hormone-activated	JJ	JJ	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	12	advcl	_	_
8	,	,	,	,	_	12	punct	_	_
9	GRbeta	grbeta	NN	NN	_	12	nsubj	_	_
10	does	do	VBZ	VBZ	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	bind	bind	VB	VB	_	0	root	_	_
13	glucocorticoids	glucocorticoid	NNS	NNS	_	12	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GCs	gc	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	12	punct	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	transcriptionally	transcriptionally	RB	RB	_	20	advmod	_	_
20	inactive	inactive	JJ	JJ	_	12	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	and	and	CC	CC	_	12	cc	_	_
23	is	be	VBZ	VBZ	_	26	cop	_	_
24	a	a	DT	DT	_	26	det	_	_
25	potential	potential	JJ	JJ	_	26	amod	_	_
26	inhibitor	inhibitor	NN	NN	_	12	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	activated	activate	VBN	VBN	_	29	amod	_	_
29	GRalpha	gralpha	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	12	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	isoforms	isoform	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	play	play	VB	VB	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	15	case	_	_
11	generalized	generalize	VBN	VBN	_	15	amod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	tissue-specific	tissue-specific	JJ	JJ	_	11	conj	_	_
14	GC	gc	NN	NN	_	15	compound	_	_
15	resistance	resistance	NN	NN	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	GCs	gc	NNS	NNS	_	2	nsubj	_	_
2	induce	induce	VBP	VBP	_	0	root	_	_
3	apoptosis	apoptosis	NN	NN	_	2	dobj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	neoplastic	neoplastic	JJ	JJ	_	7	amod	_	_
6	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	;	;	:	:	_	2	punct	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	,	,	,	,	_	2	punct	_	_
11	defective	defective	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	implicated	implicate	VBN	VBN	_	2	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	genesis	genesis	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	chronic	chronic	JJ	JJ	_	21	amod	_	_
20	lymphocytic	lymphocytic	JJ	JJ	_	21	amod	_	_
21	leukemia	leukemia	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	CLL	cll	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	patient	patient	NN	NN	_	2	dobj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	generalized	generalize	VBN	VBN	_	8	amod	_	_
7	GC	gc	NN	NN	_	8	compound	_	_
8	resistance	resistance	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CLL	cll	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	2	punct	_	_

1	GR	gr	NN	NN	_	2	compound	_	_
2	number	number	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	patient	patient	NN	NN	_	8	nmod:poss	_	_
6	's	's	POS	POS	_	5	case	_	_
7	transformed	transform	VBN	VBN	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	12	cop	_	_
10	approximately	approximately	RB	RB	_	12	advmod	_	_
11	one	one	CD	CD	_	12	compound	_	_
12	half	half	NN	NN	_	0	root	_	_
13	that	that	DT	DT	_	12	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	control	control	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	with	with	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	approximately	approximately	RB	RB	_	20	advmod	_	_
20	10-fold	10-fold	JJ	JJ	_	21	nummod	_	_
21	reduction	reduction	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	affinity	affinity	NN	NN	_	21	nmod	_	_
25	for	for	IN	IN	_	26	case	_	_
26	dexamethasone	dexamethasone	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	In	in	FW	FW	_	4	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	apoptosis	apoptosis	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	9	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	CLL	cll	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	delayed	delay	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	response	response	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	GCs	gc	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	but	but	CC	CC	_	16	cc	_	_
16	not	not	RB	RB	_	13	cc	_	_
17	to	to	TO	TO	_	20	case	_	_
18	other	other	JJ	JJ	_	20	amod	_	_
19	apoptosis	apoptosis	NN	NN	_	20	compound	_	_
20	inducers	inducer	NNS	NNS	_	13	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	Sequencing	sequencing	NN	NN	_	30	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	GR	gr	NN	NN	_	5	compound	_	_
5	cDNA	cdna	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	gene	gene	NN	NN	_	5	conj	_	_
8	including	include	VBG	VBG	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	2.3-kb	2.3-kb	JJ	JJ	_	12	amod	_	_
11	coding	coding	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	intron/exon	intron/exon	NN	NN	_	16	compound	_	_
16	junctions	junction	NNS	NNS	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	the	the	DT	DT	_	21	det	_	_
19	known	known	JJ	JJ	_	21	amod	_	_
20	5'-regulatory	5'-regulatory	JJ	JJ	_	21	amod	_	_
21	region	region	NN	NN	_	12	conj	_	_
22	,	,	,	,	_	12	punct	_	_
23	and	and	CC	CC	_	12	cc	_	_
24	approximately	approximately	RB	RB	_	25	advmod	_	_
25	300	300	CD	CD	_	26	nummod	_	_
26	bp	bp	NN	NN	_	12	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	3'-region	3'-region	NN	NN	_	26	nmod	_	_
30	revealed	reveal	VBD	VBD	_	0	root	_	_
31	no	no	DT	DT	_	32	neg	_	_
32	alterations	alteration	NNS	NNS	_	30	dobj	_	_
33	.	.	.	.	_	30	punct	_	_

1	Western	western	NN	NN	_	2	compound	_	_
2	blot	blot	NN	NN	_	7	nsubj	_	_
3	with	with	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	N-terminal	n-terminal	JJ	JJ	_	6	amod	_	_
6	antibody	antibody	NN	NN	_	2	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	normal	normal	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	immunoreactive	immunoreactive	JJ	JJ	_	12	amod	_	_
12	GR	gr	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	but	but	CC	CC	_	7	cc	_	_
15	quantitative	quantitative	JJ	JJ	_	16	amod	_	_
16	analysis	analysis	NN	NN	_	21	nsubj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	isoform-specific	isoform-specific	JJ	JJ	_	20	amod	_	_
19	C-terminal	c-terminal	JJ	JJ	_	20	amod	_	_
20	antibodies	antibody	NNS	NNS	_	16	nmod	_	_
21	revealed	reveal	VBD	VBD	_	7	conj	_	_
22	a	a	DT	DT	_	26	det	_	_
23	markedly	markedly	RB	RB	_	24	advmod	_	_
24	reduced	reduce	VBN	VBN	_	26	amod	_	_
25	GRalpha	gralpha	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	21	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	and	and	CC	CC	_	26	cc	_	_
29	high	high	JJ	JJ	_	31	amod	_	_
30	GRbeta	grbeta	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	imbalanced	imbalanced	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	GR	gr	NN	NN	_	10	compound	_	_
10	isoforms	isoform	NNS	NNS	_	6	nmod	_	_
11	may	may	MD	MD	_	14	aux	_	_
12	be	be	VB	VB	_	14	cop	_	_
13	a	a	DT	DT	_	14	det	_	_
14	mechanism	mechanism	NN	NN	_	3	ccomp	_	_
15	of	of	IN	IN	_	17	case	_	_
16	GC	gc	NN	NN	_	17	compound	_	_
17	resistance	resistance	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	may	may	MD	MD	_	21	aux	_	_
21	have	have	VB	VB	_	14	conj	_	_
22	implications	implication	NNS	NNS	_	21	dobj	_	_
23	for	for	IN	IN	_	24	case	_	_
24	tumorigenesis	tumorigenesis	NN	NN	_	22	nmod	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	enhancing	enhance	VBG	VBG	_	21	advcl	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	survival	survival	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	3	compound	_	_
2	D3	d3	NN	NN	_	3	compound	_	_
3	receptors	receptor	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	renal	renal	JJ	JJ	_	13	amod	_	_
13	insufficiency	insufficiency	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	reduced	reduce	VBN	VBN	_	3	amod	_	_
3	expression	expression	NN	NN	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	vitamin	vitamin	NN	NN	_	8	compound	_	_
7	D	d	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VDR	vdr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	parathyroid	parathyroid	JJ	JJ	_	14	amod	_	_
14	glands	gland	NNS	NNS	_	3	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	uremic	uremic	JJ	JJ	_	17	amod	_	_
17	animals	animal	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	humans	human	NNS	NNS	_	17	conj	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	observed	observe	VBN	VBN	_	0	root	_	_
23	.	.	.	.	_	22	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	obtained	obtain	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	our	we	PRP$	PRP$	_	9	nmod:poss	_	_
8	own	own	JJ	JJ	_	9	amod	_	_
9	group	group	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	5	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	PBMC	pbmc	NNS	NNS	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	from	from	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	14	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	secondary	secondary	JJ	JJ	_	22	amod	_	_
22	hyperparathyroidism	hyperparathyroidism	NN	NN	_	19	nmod	_	_
23	to	to	TO	TO	_	26	case	_	_
24	chronic	chronic	JJ	JJ	_	26	amod	_	_
25	renal	renal	JJ	JJ	_	26	amod	_	_
26	failure	failure	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	reasons	reason	NNS	NNS	_	10	nsubj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	changes	change	NNS	NNS	_	4	nmod	_	_
8	are	be	VBP	VBP	_	10	cop	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	clear	clear	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	specific	specific	JJ	JJ	_	11	amod	_	_
11	uptake	uptake	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	-LSB-3H-RSB-1,25(OH)2D3	-lsb-3h-rsb-1,25(oh)2d3	NN	NN	_	11	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	PBMC	pbmc	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	11	11	CD	CD	_	18	nummod	_	_
18	women	woman	NNS	NNS	_	15	nmod	_	_
19	with	with	IN	IN	_	23	case	_	_
20	advanced	advanced	JJ	JJ	_	23	amod	_	_
21	chronic	chronic	JJ	JJ	_	23	amod	_	_
22	renal	renal	JJ	JJ	_	23	amod	_	_
23	failure	failure	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	A-CRF	a-crf	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	18	punct	_	_
28	6	6	CD	CD	_	29	nummod	_	_
29	women	woman	NNS	NNS	_	18	conj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	mild-moderate	mild-moderate	JJ	JJ	_	33	amod	_	_
32	renal	renal	JJ	JJ	_	33	amod	_	_
33	insufficiency	insufficiency	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	M-CRF	m-crf	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	,	,	,	,	_	18	punct	_	_
38	and	and	CC	CC	_	18	cc	_	_
39	23	23	CD	CD	_	41	nummod	_	_
40	healthy	healthy	JJ	JJ	_	41	amod	_	_
41	women	woman	NNS	NNS	_	18	conj	_	_
42	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	mean	mean	JJ	JJ	_	4	amod	_	_
3	dissociation	dissociation	NN	NN	_	4	compound	_	_
4	constant	constant	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	KD	kd	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	similar	similar	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	CC	CC	_	12	dep	_	_
12	groups	group	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	in	in	IN	IN	_	18	case	_	_
17	healthy	healthy	JJ	JJ	_	18	amod	_	_
18	women	woman	NNS	NNS	_	12	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	A-CRF	a-crf	NN	NN	_	9	dep	_	_
21	:	:	:	:	_	20	punct	_	_
22	0.7	0.7	CD	CD	_	27	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	0.5	0.5	CD	CD	_	22	conj	_	_
25	x	x	CC	CC	_	24	cc	_	_
26	10(-10)	10(-10)	CD	CD	_	24	conj	_	_
27	M	m	NN	NN	_	20	dep	_	_
28	;	;	:	:	_	20	punct	_	_
29	M-CRF	m-crf	NN	NN	_	20	dep	_	_
30	:	:	:	:	_	29	punct	_	_
31	1.1	1.1	CD	CD	_	36	nummod	_	_
32	+/-	+/-	CC	CC	_	31	cc	_	_
33	0.9	0.9	CD	CD	_	31	conj	_	_
34	x	x	CC	CC	_	33	cc	_	_
35	10(-10)	10(-10)	CD	CD	_	33	conj	_	_
36	M	m	NN	NN	_	29	dep	_	_
37	;	;	:	:	_	20	punct	_	_
38	controls	control	NNS	NNS	_	20	dep	_	_
39	:	:	:	:	_	38	punct	_	_
40	1.0	1.0	CD	CD	_	45	nummod	_	_
41	+/-	+/-	CC	CC	_	40	cc	_	_
42	0.6	0.6	CD	CD	_	40	conj	_	_
43	x	x	CC	CC	_	42	cc	_	_
44	10(-10)	10(-10)	CD	CD	_	42	conj	_	_
45	M	m	NN	NN	_	38	dep	_	_
46	)	)	-RRB-	-RRB-	_	20	punct	_	_
47	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	VDR	vdr	NN	NN	_	4	compound	_	_
4	concentration	concentration	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	decreased	decrease	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	A-CRF	a-crf	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	0.8	0.8	CD	CD	_	15	nummod	_	_
12	+/-	+/-	CC	CC	_	11	cc	_	_
13	0.5	0.5	CD	CD	_	11	conj	_	_
14	fmol/10(7)	fmol/10(7)	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	dep	_	_
16	vs.	vs.	CC	CC	_	15	cc	_	_
17	2.3	2.3	CD	CD	_	21	nummod	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	0.9	0.9	CD	CD	_	17	conj	_	_
20	fmol/10(7)	fmol/10(7)	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	conj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	controls	control	NNS	NNS	_	15	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	p	p	NN	NN	_	26	dep	_	_
26	&lt;	&lt;	JJR	JJR	_	15	dep	_	_
27	0.001	0.001	CD	CD	_	26	nummod	_	_
28	)	)	-RRB-	-RRB-	_	15	punct	_	_
29	,	,	,	,	_	7	punct	_	_
30	whereas	whereas	IN	IN	_	7	dep	_	_
31	no	no	DT	DT	_	32	neg	_	_
32	changes	change	NNS	NNS	_	34	nsubjpass	_	_
33	were	be	VBD	VBD	_	34	auxpass	_	_
34	seen	see	VBN	VBN	_	7	parataxis	_	_
35	in	in	IN	IN	_	36	case	_	_
36	M-CRF	m-crf	NN	NN	_	34	nmod	_	_
37	(	(	-LRB-	-LRB-	_	42	punct	_	_
38	1.7	1.7	CD	CD	_	42	nummod	_	_
39	+/-	+/-	CC	CC	_	38	cc	_	_
40	0.7	0.7	CD	CD	_	38	conj	_	_
41	fmol/10(7)	fmol/10(7)	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	34	dep	_	_
43	vs.	vs.	CC	CC	_	42	cc	_	_
44	2.3	2.3	CD	CD	_	48	nummod	_	_
45	+/-	+/-	CC	CC	_	44	cc	_	_
46	0.9	0.9	CD	CD	_	44	conj	_	_
47	fmol/10(7)	fmol/10(7)	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	42	conj	_	_
49	in	in	IN	IN	_	50	case	_	_
50	controls	control	NNS	NNS	_	42	nmod	_	_
51	)	)	-RRB-	-RRB-	_	42	punct	_	_
52	.	.	.	.	_	7	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlation	correlation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	seen	see	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	9	case	_	_
6	VDR	vdr	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	serum	serum	NN	NN	_	6	conj	_	_
9	calcitriol	calcitriol	NN	NN	_	4	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	PTH	pth	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	when	when	WRB	WRB	_	15	advmod	_	_
15	considering	consider	VBG	VBG	_	4	advcl	_	_
16	both	both	DT	DT	_	17	det	_	_
17	groups	group	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	together	together	RB	RB	_	21	advmod	_	_
21	or	or	CC	CC	_	15	advmod	_	_
22	separately	separately	RB	RB	_	21	advmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Conversely	conversely	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	significant	significant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	between	between	IN	IN	_	14	case	_	_
10	VDR	vdr	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	serum	serum	NN	NN	_	10	conj	_	_
13	creatinine	creatinine	NN	NN	_	14	compound	_	_
14	values	value	NNS	NNS	_	8	nmod	_	_
15	when	when	WRB	WRB	_	20	advmod	_	_
16	A-CRF	a-crf	NN	NN	_	20	nsubjpass	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	M-CRF	m-crf	NN	NN	_	16	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	considered	consider	VBN	VBN	_	8	advcl	_	_
21	altogether	altogether	RB	RB	_	20	advmod	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	r	r	NN	NN	_	24	nsubj	_	_
24	=	=	JJ	JJ	_	20	parataxis	_	_
25	-0.63	-0.63	CD	CD	_	24	dobj	_	_
26	;	;	:	:	_	24	punct	_	_
27	p	p	NN	NN	_	28	dep	_	_
28	&lt;	&lt;	JJR	JJR	_	24	parataxis	_	_
29	0.01	0.01	CD	CD	_	28	nummod	_	_
30	)	)	-RRB-	-RRB-	_	24	punct	_	_
31	.	.	.	.	_	8	punct	_	_

1	Treatment	treatment	NN	NN	_	30	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	different	different	JJ	JJ	_	5	amod	_	_
5	schedules	schedule	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	oral	oral	JJ	JJ	_	8	amod	_	_
8	calcitriol	calcitriol	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	5	punct	_	_
10	five	five	CD	CD	_	11	nummod	_	_
11	patients	patient	NNS	NNS	_	5	dep	_	_
12	with	with	IN	IN	_	14	case	_	_
13	0.5	0.5	CD	CD	_	14	nummod	_	_
14	microgram/day	microgram/day	NNS	NNS	_	11	nmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	1	1	CD	CD	_	17	nummod	_	_
17	month	month	NN	NN	_	11	nmod	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	four	four	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	11	conj	_	_
21	with	with	IN	IN	_	23	case	_	_
22	2	2	CD	CD	_	23	nummod	_	_
23	micrograms/day	micrograms/day	NN	NN	_	20	nmod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	7	7	CD	CD	_	26	nummod	_	_
26	days	day	NNS	NNS	_	20	nmod	_	_
27	)	)	-RRB-	-RRB-	_	5	punct	_	_
28	did	do	VBD	VBD	_	30	aux	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	change	change	VB	VB	_	0	root	_	_
31	VDR	vdr	NN	NN	_	32	compound	_	_
32	concentrations	concentration	NNS	NNS	_	30	dobj	_	_
33	.	.	.	.	_	30	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	low	low	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	14	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	serum	serum	NN	NN	_	9	compound	_	_
9	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	uremia	uremia	NN	NN	_	9	nmod	_	_
12	are	be	VBP	VBP	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	responsible	responsible	JJ	JJ	_	2	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	decrease	decrease	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	VDR	vdr	NN	NN	_	20	compound	_	_
20	concentration	concentration	NN	NN	_	17	nmod	_	_
21	found	find	VBN	VBN	_	17	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	patients	patient	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	novel	novel	JJ	JJ	_	6	amod	_	_
3	growth-factor-dependent	growth-factor-dependent	JJ	JJ	_	6	amod	_	_
4	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	line	line	NN	NN	_	13	nsubj	_	_
7	derived	derive	VBN	VBN	_	6	acl	_	_
8	from	from	IN	IN	_	12	case	_	_
9	mouse	mouse	NN	NN	_	12	compound	_	_
10	bone	bone	NN	NN	_	12	compound	_	_
11	marrow	marrow	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	contains	contain	VBZ	VBZ	_	0	root	_	_
14	progenitors	progenitor	NNS	NNS	_	13	dobj	_	_
15	endowed	endowed	JJ	JJ	_	14	dep	_	_
16	with	with	IN	IN	_	19	case	_	_
17	high	high	JJ	JJ	_	19	amod	_	_
18	proliferative	proliferative	JJ	JJ	_	19	amod	_	_
19	potential	potential	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	colony-stimulating	colony-stimulating	JJ	JJ	_	7	amod	_	_
6	factor-1	factor-1	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	CSF-1R	csf-1r	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	confers	confer	VBZ	VBZ	_	0	root	_	_
12	long-lasting	long-lasting	JJ	JJ	_	14	amod	_	_
13	CSF-1-dependent	csf-1-dependent	JJ	JJ	_	14	amod	_	_
14	proliferation	proliferation	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	19	case	_	_
16	mouse	mouse	NN	NN	_	19	compound	_	_
17	myeloid	myeloid	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	developed	develop	VBD	VBD	_	0	root	_	_
3	mice	mouse	NNS	NNS	_	2	dobj	_	_
4	transgenic	transgenic	JJ	JJ	_	3	amod	_	_
5	for	for	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	CSF-1R	csf-1r	NN	NN	_	4	nmod	_	_
8	because	because	IN	IN	_	13	mark	_	_
9	mouse	mouse	NN	NN	_	10	compound	_	_
10	CSF-1	csf-1	NN	NN	_	13	nsubj	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	activate	activate	VB	VB	_	2	advcl	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	CSF-1R	csf-1r	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Then	then	RB	RB	_	9	advmod	_	_
2	bone	bone	NN	NN	_	4	compound	_	_
3	marrow	marrow	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	9	nsubjpass	_	_
5	from	from	IN	IN	_	7	case	_	_
6	transgenic	transgenic	JJ	JJ	_	7	amod	_	_
7	mice	mouse	NNS	NNS	_	4	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	plated	plate	VBN	VBN	_	0	root	_	_
10	onto	onto	IN	IN	_	13	case	_	_
11	MS-5	ms-5	NN	NN	_	13	compound	_	_
12	stromal	stromal	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	expressing	express	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	17	det	_	_
16	membrane	membrane	NN	NN	_	17	compound	_	_
17	form	form	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	CSF-1	csf-1	NN	NN	_	17	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	2M-1	2m-1	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	in	in	IN	IN	_	28	mark	_	_
26	order	order	NN	NN	_	25	mwe	_	_
27	to	to	TO	TO	_	28	dep	_	_
28	combine	combine	VB	VB	_	9	advcl	_	_
29	the	the	DT	DT	_	32	det	_	_
30	hematopoietic	hematopoietic	JJ	JJ	_	32	amod	_	_
31	supporting	supporting	NN	NN	_	32	compound	_	_
32	properties	property	NNS	NNS	_	28	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	stromal	stromal	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	the	the	DT	DT	_	39	det	_	_
38	proliferative	proliferative	JJ	JJ	_	39	amod	_	_
39	effects	effect	NNS	NNS	_	32	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	CSF-1	csf-1	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	9	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	derive	derive	VB	VB	_	5	xcomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	called	call	VBN	VBN	_	11	acl	_	_
14	47.10	47.10	CD	CD	_	13	xcomp	_	_
15	,	,	,	,	_	11	punct	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	grew	grow	VBD	VBD	_	11	acl:relcl	_	_
18	indefinitely	indefinitely	RB	RB	_	17	advmod	_	_
19	under	under	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	conditions	condition	NNS	NNS	_	17	nmod	_	_
22	,	,	,	,	_	5	punct	_	_
23	whereas	whereas	IN	IN	_	5	dep	_	_
24	no	no	DT	DT	_	26	neg	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	29	nsubjpass	_	_
27	could	could	MD	MD	_	29	aux	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	developed	develop	VBN	VBN	_	5	parataxis	_	_
30	from	from	IN	IN	_	32	case	_	_
31	nontransgenic	nontransgenic	JJ	JJ	_	32	amod	_	_
32	mice	mouse	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Proliferation	proliferation	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	47.10	47.10	CD	CD	_	4	nummod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	severely	severely	RB	RB	_	7	advmod	_	_
7	affected	affect	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	neutralizing	neutralize	VBG	VBG	_	7	advcl	_	_
10	anti-CSF-1R	anti-csf-1r	JJ	JJ	_	12	amod	_	_
11	monoclonal	monoclonal	JJ	JJ	_	12	amod	_	_
12	antibodies	antibody	NNS	NNS	_	9	dobj	_	_
13	.	.	.	.	_	7	punct	_	_

1	Morphologic	morphologic	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	cytofluorometry	cytofluorometry	NN	NN	_	1	conj	_	_
4	analysis	analysis	NN	NN	_	5	nsubj	_	_
5	established	establish	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	most	most	JJS	JJS	_	9	amod	_	_
8	47.10	47.10	CD	CD	_	9	nummod	_	_
9	cells	cell	NNS	NNS	_	13	nsubj	_	_
10	are	be	VBP	VBP	_	13	cop	_	_
11	immature	immature	JJ	JJ	_	13	amod	_	_
12	myelomonocytic	myelomonocytic	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	5	ccomp	_	_
14	.	.	.	.	_	5	punct	_	_

1	Consistent	consistent	JJ	JJ	_	21	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	phenotype	phenotype	NN	NN	_	1	nmod	_	_
5	,	,	,	,	_	21	punct	_	_
6	the	the	DT	DT	_	10	det	_	_
7	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	PU.1	pu.1	NN	NN	_	21	nsubjpass	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	10	cc	_	_
14	the	the	DT	DT	_	18	det	_	_
15	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
16	transcription	transcription	NN	NN	_	18	compound	_	_
17	factor	factor	NN	NN	_	18	compound	_	_
18	GATA-1	gata-1	NN	NN	_	10	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	expressed	express	VBN	VBN	_	0	root	_	_
22	in	in	IN	IN	_	24	case	_	_
23	47.10	47.10	CD	CD	_	24	nummod	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	21	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	few	few	JJ	JJ	_	4	amod	_	_
3	47.10	47.10	CD	CD	_	4	nummod	_	_
4	cells	cell	NNS	NNS	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	3-5	3-5	CD	CD	_	7	nummod	_	_
7	%	%	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	do	do	VBP	VBP	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	express	express	VB	VB	_	0	root	_	_
12	lineage	lineage	NN	NN	_	14	compound	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	markers	marker	NNS	NNS	_	11	dobj	_	_
15	;	;	:	:	_	11	punct	_	_
16	they	they	PRP	PRP	_	17	nsubj	_	_
17	differentiate	differentiate	VBP	VBP	_	11	parataxis	_	_
18	spontaneously	spontaneously	RB	RB	_	17	advmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	lineage-positive	lineage-positive	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	after	after	IN	IN	_	23	mark	_	_
23	replating	replate	VBG	VBG	_	17	advcl	_	_
24	on	on	IN	IN	_	26	case	_	_
25	2M-1	2m-1	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	agar	agar	NN	NN	_	3	compound	_	_
3	cultures	culture	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	47.10	47.10	CD	CD	_	6	nummod	_	_
6	cells	cell	NNS	NNS	_	7	nsubj	_	_
7	form	form	VBP	VBP	_	0	root	_	_
8	7-	7-	CD	CD	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	14-day	14-day	JJ	JJ	_	8	conj	_	_
11	colonies	colony	NNS	NNS	_	7	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	response	response	NN	NN	_	16	dep	_	_
14	to	to	TO	TO	_	16	case	_	_
15	a	a	DT	DT	_	16	det	_	_
16	cocktail	cocktail	NN	NN	_	7	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	granulocyte/macrophage	granulocyte/macrophage	NN	NN	_	20	compound	_	_
19	colony-stimulating	colony-stimulating	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	2.5	2.5	CD	CD	_	23	nummod	_	_
23	ng/mL	ng/ml	NN	NN	_	20	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	20	punct	_	_
26	interleukin-3	interleukin-3	NN	NN	_	20	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	1	1	CD	CD	_	29	nummod	_	_
29	ng/mL	ng/ml	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	20	punct	_	_
32	and	and	CC	CC	_	20	cc	_	_
33	mouse	mouse	NN	NN	_	34	compound	_	_
34	CSF-1	csf-1	NN	NN	_	20	conj	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	10	10	CD	CD	_	37	nummod	_	_
37	ng/mL	ng/ml	NN	NN	_	34	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	.	.	.	.	_	7	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	about	about	RB	RB	_	6	advmod	_	_
6	0.5	0.5	CD	CD	_	7	nummod	_	_
7	%	%	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	47.10	47.10	CD	CD	_	10	nummod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	formed	form	VBD	VBD	_	0	root	_	_
12	large	large	JJ	JJ	_	14	amod	_	_
13	14-day	14-day	JJ	JJ	_	14	amod	_	_
14	colonies	colony	NNS	NNS	_	11	dobj	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	&gt;	&gt;	JJR	JJR	_	17	advmod	_	_
17	1	1	CD	CD	_	18	nummod	_	_
18	mm	mm	NN	NN	_	14	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	composed	compose	VBN	VBN	_	14	acl	_	_
21	of	of	IN	IN	_	23	case	_	_
22	mature	mature	JJ	JJ	_	23	amod	_	_
23	monocytes	monocyte	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	granulocytes	granulocyte	NNS	NNS	_	23	conj	_	_
26	,	,	,	,	_	11	punct	_	_
27	reflecting	reflect	VBG	VBG	_	11	advcl	_	_
28	the	the	DT	DT	_	29	det	_	_
29	presence	presence	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	progenitors	progenitor	NNS	NNS	_	29	nmod	_	_
32	endowed	endowed	JJ	JJ	_	31	dep	_	_
33	with	with	IN	IN	_	36	case	_	_
34	high	high	JJ	JJ	_	36	amod	_	_
35	proliferative	proliferative	JJ	JJ	_	36	amod	_	_
36	potential	potential	NN	NN	_	32	nmod	_	_
37	(	(	-LRB-	-LRB-	_	39	punct	_	_
38	HPP-47.10	hpp-47.10	CD	CD	_	39	nummod	_	_
39	cells	cell	NNS	NNS	_	36	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	12	det	_	_
8	novel	novel	JJ	JJ	_	12	amod	_	_
9	continuous	continuous	JJ	JJ	_	12	amod	_	_
10	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	6	dobj	_	_
13	presenting	present	VBG	VBG	_	12	acl	_	_
14	a	a	DT	DT	_	16	det	_	_
15	hierarchical	hierarchical	JJ	JJ	_	16	amod	_	_
16	structure	structure	NN	NN	_	13	dobj	_	_
17	similar	similar	JJ	JJ	_	16	amod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	that	that	DT	DT	_	17	nmod	_	_
20	of	of	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	bone	bone	NN	NN	_	26	compound	_	_
23	marrow	marrow	NN	NN	_	26	compound	_	_
24	progenitor	progenitor	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	compartment	compartment	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	effects	effect	NNS	NNS	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	chromosome	chromosome	NN	NN	_	6	compound	_	_
6	constitution	constitution	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	hybrids	hybrid	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	9	advmod	_	_
2	immunoglobulin	immunoglobulin	NN	NN	_	7	compound	_	_
3	(	(	-LRB-	-LRB-	_	7	punct	_	_
4	Ig	ig	NN	NN	_	7	compound	_	_
5	)	)	-RRB-	-RRB-	_	7	punct	_	_
6	-secreting	-secreting	JJ	JJ	_	7	amod	_	_
7	plasmacytomas	plasmacytoma	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	fused	fuse	VBN	VBN	_	18	advcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	lymphoma	lymphoma	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	Ig	ig	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	18	nsubj	_	_
18	ceases	cease	VBZ	VBZ	_	0	root	_	_
19	in	in	IN	IN	_	23	case	_	_
20	greater	greater	JJR	JJR	_	22	advmod	_	_
21	than	than	IN	IN	_	22	advmod	_	_
22	95	95	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	resulting	result	VBG	VBG	_	27	amod	_	_
27	hybrids	hybrid	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	rare	rare	JJ	JJ	_	4	amod	_	_
4	hybrids	hybrid	NNS	NNS	_	18	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	continue	continue	VBP	VBP	_	4	acl:relcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	express	express	VB	VB	_	6	xcomp	_	_
9	Ig	ig	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	18	punct	_	_
11	all	all	DT	DT	_	16	det	_	_
12	other	other	JJ	JJ	_	16	amod	_	_
13	tested	test	VBN	VBN	_	16	amod	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	16	amod	_	_
16	genes	gene	NNS	NNS	_	18	nsubj	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	remain	remain	VBP	VBP	_	0	root	_	_
19	active	active	JJ	JJ	_	18	xcomp	_	_
20	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	low	low	JJ	JJ	_	3	amod	_	_
3	frequency	frequency	NN	NN	_	25	nsubj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	10	nmod	_	_
6	these	these	DT	DT	_	8	det	_	_
7	Ig-expressing	ig-expressing	JJ	JJ	_	8	amod	_	_
8	hybrids	hybrid	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	recovered	recover	VBN	VBN	_	3	acl:relcl	_	_
11	,	,	,	,	_	3	punct	_	_
12	along	along	IN	IN	_	3	cc	_	_
13	with	with	IN	IN	_	12	dep	_	_
14	the	the	DT	DT	_	15	det	_	_
15	fact	fact	NN	NN	_	3	conj	_	_
16	that	that	IN	IN	_	20	mark	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	fusions	fusion	NNS	NNS	_	20	nsubj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	lead	lead	VB	VB	_	15	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	chromosome	chromosome	NN	NN	_	23	compound	_	_
23	loss	loss	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	3	punct	_	_
25	led	lead	VBD	VBD	_	0	root	_	_
26	us	we	PRP	PRP	_	25	dobj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	propose	propose	VB	VB	_	25	xcomp	_	_
29	that	that	IN	IN	_	36	mark	_	_
30	this	this	DT	DT	_	32	det	_	_
31	rare	rare	JJ	JJ	_	32	amod	_	_
32	phenotype	phenotype	NN	NN	_	36	nsubj	_	_
33	was	be	VBD	VBD	_	36	cop	_	_
34	due	due	JJ	JJ	_	36	case	_	_
35	to	to	TO	TO	_	34	mwe	_	_
36	loss	loss	NN	NN	_	28	ccomp	_	_
37	of	of	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	T-cell-derived	t-cell-derived	JJ	JJ	_	40	amod	_	_
40	chromosome	chromosome	NN	NN	_	36	nmod	_	_
41	encoding	encode	VBG	VBG	_	40	acl	_	_
42	a	a	DT	DT	_	43	det	_	_
43	factor	factor	NN	NN	_	41	dobj	_	_
44	or	or	CC	CC	_	43	cc	_	_
45	factors	factor	NNS	NNS	_	43	conj	_	_
46	with	with	IN	IN	_	49	case	_	_
47	gene	gene	NN	NN	_	49	compound	_	_
48	silencing	silencing	NN	NN	_	49	compound	_	_
49	activity	activity	NN	NN	_	43	nmod	_	_
50	.	.	.	.	_	25	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	identify	identify	VB	VB	_	9	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	relevant	relevant	JJ	JJ	_	5	amod	_	_
5	chromosome	chromosome	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	9	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	used	use	VBN	VBN	_	0	root	_	_
10	a	a	DT	DT	_	18	det	_	_
11	polymerase	polymerase	NN	NN	_	13	compound	_	_
12	chain	chain	NN	NN	_	13	compound	_	_
13	reaction	reaction	NN	NN	_	17	nmod:npmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PCR	pcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-assisted	-assisted	JJ	JJ	_	18	amod	_	_
18	method	method	NN	NN	_	9	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	chromosome	chromosome	NN	NN	_	21	compound	_	_
21	mapping	mapping	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	analyze	analyze	VB	VB	_	9	advcl	_	_
24	both	both	CC	CC	_	25	cc:preconj	_	_
25	Ig-silenced	ig-silenced	JJ	JJ	_	34	amod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	common	common	JJ	JJ	_	25	dep	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	Ig-expressing	ig-expressing	JJ	JJ	_	25	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	rare	rare	JJ	JJ	_	30	dep	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	hybrids	hybrid	NNS	NNS	_	23	dobj	_	_
35	.	.	.	.	_	9	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	no	no	DT	DT	_	4	neg	_	_
3	single	single	JJ	JJ	_	4	amod	_	_
4	chromosome	chromosome	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	15	advcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	correlate	correlate	VB	VB	_	6	xcomp	_	_
9	with	with	IN	IN	_	12	case	_	_
10	Ig	ig	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	silencing	silencing	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	discovered	discover	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	19	det	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	types	type	NNS	NNS	_	23	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	hybrids	hybrid	NNS	NNS	_	19	nmod	_	_
22	had	have	VBD	VBD	_	23	aux	_	_
23	undergone	undergo	VBN	VBN	_	15	ccomp	_	_
24	distinct	distinct	JJ	JJ	_	25	amod	_	_
25	patterns	pattern	NNS	NNS	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	chromosome	chromosome	NN	NN	_	28	compound	_	_
28	loss	loss	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	17	mark	_	_
6	ectopic	ectopic	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	B-cell-specific	b-cell-specific	JJ	JJ	_	12	amod	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	Oct-2	oct-2	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	dramatically	dramatically	RB	RB	_	17	advmod	_	_
17	altered	alter	VBD	VBD	_	4	ccomp	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	phenotype	phenotype	NN	NN	_	17	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	chromosome	chromosome	NN	NN	_	23	compound	_	_
23	constitution	constitution	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	hybrids	hybrid	NNS	NNS	_	20	nmod	_	_
26	arising	arise	VBG	VBG	_	25	acl	_	_
27	in	in	IN	IN	_	30	case	_	_
28	these	these	DT	DT	_	30	det	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	fusions	fusion	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HTLV-I	htlv-i	NN	NN	_	1	nmod	_	_
4	basal	basal	JJ	JJ	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	3	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	expression	expression	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	CREB/ATF-1/CREM	creb/atf-1/crem	NN	NN	_	11	compound	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	members	member	NNS	NNS	_	3	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	peripheral	peripheral	JJ	JJ	_	16	amod	_	_
14	blood	blood	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	3	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Jurkat	jurkat	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	1	punct	_	_

1	HTLV-I	htlv-i	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	etiologic	etiologic	JJ	JJ	_	5	amod	_	_
5	agent	agent	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	adult	adult	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	leukemia/lymphoma	leukemia/lymphoma	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	5	conj	_	_
13	with	with	IN	IN	_	17	case	_	_
14	tropical	tropical	JJ	JJ	_	17	amod	_	_
15	spastic	spastic	JJ	JJ	_	17	amod	_	_
16	paraparesis/HTLV-I-associated	paraparesis/htlv-i-associated	JJ	JJ	_	17	amod	_	_
17	myelopathy	myelopathy	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Following	follow	VBG	VBG	_	2	case	_	_
2	integration	integration	NN	NN	_	12	nmod	_	_
3	into	into	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	host	host	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	genome	genome	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	regulated	regulate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	18	case	_	_
14	both	both	CC	CC	_	18	dep	_	_
15	host	host	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	viral	viral	JJ	JJ	_	14	conj	_	_
18	mechanisms	mechanism	NNS	NNS	_	12	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	control	control	VBP	VBP	_	18	acl:relcl	_	_
21	transcription	transcription	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	12	punct	_	_

1	Low	low	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	viral	viral	JJ	JJ	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	basal	basal	JJ	JJ	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	occur	occur	VBP	VBP	_	0	root	_	_
11	before	before	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	virally	virally	RB	RB	_	18	advmod	_	_
16	encoded	encode	VBN	VBN	_	18	amod	_	_
17	Tax	tax	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	Tax-mediated	tax-mediated	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	10	punct	_	_

1	Members	member	NNS	NNS	_	27	nsubj	_	_
2	of	of	IN	IN	_	23	case	_	_
3	the	the	DT	DT	_	23	det	_	_
4	cyclic	cyclic	JJ	JJ	_	23	amod	_	_
5	adenosine	adenosine	NN	NN	_	23	compound	_	_
6	monophosphate	monophosphate	NN	NN	_	23	compound	_	_
7	(	(	-LRB-	-LRB-	_	23	punct	_	_
8	cAMP	camp	NN	NN	_	23	compound	_	_
9	)	)	-RRB-	-RRB-	_	23	punct	_	_
10	response	response	VBP	VBP	_	23	dep	_	_
11	element	element	NN	NN	_	23	compound	_	_
12	binding	binding	NN	NN	_	23	compound	_	_
13	(	(	-LRB-	-LRB-	_	23	punct	_	_
14	CREB	creb	NN	NN	_	23	compound	_	_
15	)	)	-RRB-	-RRB-	_	23	punct	_	_
16	/activating	/activating	VBG	VBG	_	23	amod	_	_
17	transcription	transcription	NN	NN	_	23	compound	_	_
18	factor	factor	NN	NN	_	23	compound	_	_
19	1	1	CD	CD	_	23	nummod	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	ATF-1	atf-1	NN	NN	_	23	compound	_	_
22	)	)	-RRB-	-RRB-	_	23	punct	_	_
23	family	family	NN	NN	_	1	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	bind	bind	VBP	VBP	_	0	root	_	_
28	three	three	CD	CD	_	30	nummod	_	_
29	21-bp	21-bp	JJ	JJ	_	30	amod	_	_
30	repeats	repeat	NNS	NNS	_	27	dobj	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	Tax-responsive	tax-responsive	JJ	JJ	_	33	amod	_	_
33	element-1	element-1	NN	NN	_	30	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	or	or	CC	CC	_	33	cc	_	_
36	TRE-1	tre-1	NN	NN	_	33	conj	_	_
37	)	)	-RRB-	-RRB-	_	33	punct	_	_
38	within	within	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	viral	viral	JJ	JJ	_	41	amod	_	_
41	promoter	promoter	NN	NN	_	30	nmod	_	_
42	and	and	CC	CC	_	27	cc	_	_
43	are	be	VBP	VBP	_	44	cop	_	_
44	important	important	JJ	JJ	_	27	conj	_	_
45	for	for	IN	IN	_	49	case	_	_
46	basal	basal	JJ	JJ	_	49	amod	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	Tax-mediated	tax-mediated	JJ	JJ	_	46	conj	_	_
49	transcription	transcription	NN	NN	_	44	nmod	_	_
50	.	.	.	.	_	27	punct	_	_

1	Using	use	VBG	VBG	_	18	advcl	_	_
2	mitogen	mitogen	NN	NN	_	3	nmod:npmod	_	_
3	stimulated	stimulated	JJ	JJ	_	9	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	quiescent	quiescent	JJ	JJ	_	3	conj	_	_
6	peripheral	peripheral	JJ	JJ	_	9	amod	_	_
7	blood	blood	NN	NN	_	9	compound	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	PBMC	pbmc	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	Jurkat	jurkat	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	conj	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	compared	compare	VBD	VBD	_	0	root	_	_
19	differences	difference	NNS	NNS	_	18	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	basal	basal	JJ	JJ	_	22	amod	_	_
22	transcription	transcription	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	amounts	amount	NNS	NNS	_	22	conj	_	_
25	and	and	CC	CC	_	22	cc	_	_
26	binding	binding	NN	NN	_	22	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factors	factor	NNS	NNS	_	22	nmod	_	_
30	with	with	IN	IN	_	31	case	_	_
31	TRE-1	tre-1	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	amounts	amount	NNS	NNS	_	14	nsubj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	transcriptionally	transcriptionally	RB	RB	_	7	advmod	_	_
7	active	active	JJ	JJ	_	10	amod	_	_
8	phosphorylated	phosphorylate	VBN	VBN	_	10	amod	_	_
9	CREB	creb	NN	NN	_	10	compound	_	_
10	protein	protein	NN	NN	_	4	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	P-CREB	p-creb	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	differ	differ	VBP	VBP	_	2	ccomp	_	_
15	between	between	IN	IN	_	17	case	_	_
16	activated	activate	VBN	VBN	_	17	amod	_	_
17	PBMC	pbmc	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Following	follow	VBG	VBG	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	P-CREB	p-creb	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	6	nsubj	_	_
6	remain	remain	VBP	VBP	_	0	root	_	_
7	elevated	elevated	JJ	JJ	_	6	xcomp	_	_
8	in	in	IN	IN	_	9	case	_	_
9	PBMC	pbmc	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	14	case	_	_
11	up	up	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	24	24	CD	CD	_	14	nummod	_	_
14	hours	hour	NNS	NNS	_	6	nmod	_	_
15	whereas	whereas	IN	IN	_	6	dep	_	_
16	CREB	creb	NN	NN	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	dephosphorylated	dephosphorylate	VBN	VBN	_	6	parataxis	_	_
19	in	in	IN	IN	_	21	case	_	_
20	Jurkat	jurkat	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	within	within	IN	IN	_	24	case	_	_
23	4	4	CD	CD	_	24	nummod	_	_
24	hours	hour	NNS	NNS	_	18	nmod	_	_
25	following	follow	VBG	VBG	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	differences	difference	NNS	NNS	_	13	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	P-CREB	p-creb	NN	NN	_	5	compound	_	_
5	levels	level	NNS	NNS	_	2	nmod	_	_
6	between	between	IN	IN	_	7	case	_	_
7	PBMC	pbmc	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Jurkat	jurkat	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	conj	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	directly	directly	RB	RB	_	13	advmod	_	_
13	correlated	correlate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	basal	basal	JJ	JJ	_	16	amod	_	_
16	transcription	transcription	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	HTLV-I	htlv-i	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	two	two	CD	CD	_	23	nummod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	types	type	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	Using	use	VBG	VBG	_	8	advcl	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	determined	determine	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	pattern	pattern	NN	NN	_	15	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	band	band	NN	NN	_	14	compound	_	_
14	migration	migration	NN	NN	_	11	nmod	_	_
15	differed	differ	VBD	VBD	_	8	ccomp	_	_
16	between	between	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	two	two	CD	CD	_	20	nummod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	types	type	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PBMC	pbmc	NN	NN	_	7	nsubj	_	_
6	differentially	differentially	RB	RB	_	7	advmod	_	_
7	regulate	regulate	VBP	VBP	_	3	ccomp	_	_
8	basal	basal	JJ	JJ	_	10	amod	_	_
9	HTLV-I	htlv-i	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	7	dobj	_	_
11	compared	compare	VBN	VBN	_	15	case	_	_
12	with	with	IN	IN	_	15	case	_	_
13	Jurkat	jurkat	NN	NN	_	15	compound	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	advcl	_	_
16	,	,	,	,	_	3	punct	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	this	this	DT	DT	_	20	det	_	_
19	differential	differential	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	25	nsubj	_	_
21	is	be	VBZ	VBZ	_	25	cop	_	_
22	due	due	JJ	JJ	_	25	case	_	_
23	,	,	,	,	_	25	punct	_	_
24	in	in	IN	IN	_	25	case	_	_
25	part	part	NN	NN	_	3	conj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	differential	differential	JJ	JJ	_	28	amod	_	_
28	phosphorylation	phosphorylation	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	binding	binding	NN	NN	_	28	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	CREB/ATF-1	creb/atf-1	NN	NN	_	30	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	TRE-1	tre-1	NN	NN	_	30	nmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	HTLV-I	htlv-i	NN	NN	_	38	compound	_	_
38	promoter	promoter	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	utility	utility	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	mark	_	_
6	using	use	VBG	VBG	_	4	acl	_	_
7	primary	primary	JJ	JJ	_	9	amod	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	models	model	NNS	NNS	_	6	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	study	study	VB	VB	_	6	advcl	_	_
12	HTLV-I	htlv-i	NN	NN	_	13	compound	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	dep	_	_
16	context	context	NN	NN	_	19	dep	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	signaling	signaling	NN	NN	_	11	nmod	_	_
20	and	and	CC	CC	_	2	cc	_	_
21	suggest	suggest	VBP	VBP	_	2	conj	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	activated	activate	VBN	VBN	_	24	amod	_	_
24	PBMC	pbmc	NN	NN	_	25	nsubj	_	_
25	maintain	maintain	VBP	VBP	_	21	ccomp	_	_
26	elevated	elevated	JJ	JJ	_	27	amod	_	_
27	levels	level	NNS	NNS	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	P-CREB	p-creb	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	27	punct	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	promote	promote	VBP	VBP	_	27	acl:relcl	_	_
33	basal	basal	JJ	JJ	_	35	amod	_	_
34	HTLV-I	htlv-i	NN	NN	_	35	compound	_	_
35	transcription	transcription	NN	NN	_	32	dobj	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	enhance	enhance	VBP	VBP	_	32	conj	_	_
38	viral	viral	JJ	JJ	_	39	amod	_	_
39	persistence	persistence	NN	NN	_	37	dobj	_	_
40	in	in	FW	FW	_	41	compound	_	_
41	vivo	vivo	FW	FW	_	37	advmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	Heterogeneity	heterogeneity	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	clonal	clonal	JJ	JJ	_	4	amod	_	_
4	development	development	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	chronic	chronic	JJ	JJ	_	8	amod	_	_
7	myeloproliferative	myeloproliferative	JJ	JJ	_	8	amod	_	_
8	disorders	disorder	NNS	NNS	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	previously	previously	RB	RB	_	7	advmod	_	_
7	unexpected	unexpected	JJ	JJ	_	8	amod	_	_
8	variability	variability	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	dominant	dominant	JJ	JJ	_	16	amod	_	_
15	neoplastic	neoplastic	JJ	JJ	_	16	amod	_	_
16	clone	clone	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	myeloproliferative	myeloproliferative	JJ	JJ	_	19	amod	_	_
19	disorders	disorder	NNS	NNS	_	11	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MPD	mpd	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	49	49	CD	CD	_	5	nummod	_	_
4	female	female	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	2	dobj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	MPD	mpd	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	informative	informative	JJ	JJ	_	7	conj	_	_
10	at	at	IN	IN	_	18	case	_	_
11	the	the	DT	DT	_	18	det	_	_
12	X-linked	x-linked	JJ	JJ	_	18	amod	_	_
13	androgen	androgen	NN	NN	_	18	compound	_	_
14	receptor	receptor	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	AR	ar	NNS	NNS	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	locus	locus	NN	NN	_	9	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	establish	establish	VB	VB	_	2	advcl	_	_
21	the	the	DT	DT	_	25	det	_	_
22	X	x	NN	NN	_	25	compound	_	_
23	chromosome	chromosome	NN	NN	_	25	compound	_	_
24	inactivation	inactivation	NN	NN	_	25	compound	_	_
25	pattern	pattern	NN	NN	_	20	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	hemopoietic	hemopoietic	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Whereas	whereas	IN	IN	_	18	mark	_	_
2	in	in	IN	IN	_	5	case	_	_
3	chronic	chronic	JJ	JJ	_	5	amod	_	_
4	myelogenous	myelogenous	JJ	JJ	_	5	amod	_	_
5	leukemia	leukemia	NN	NN	_	18	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	CML	cml	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	granulocytes	granulocyte	NNS	NNS	_	18	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PMN	pmn	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	were	be	VBD	VBD	_	18	cop	_	_
15	uniformly	uniformly	RB	RB	_	18	advmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	monoclonal	monoclonal	JJ	JJ	_	18	amod	_	_
18	origin	origin	NN	NN	_	27	advcl	_	_
19	,	,	,	,	_	27	punct	_	_
20	a	a	DT	DT	_	22	det	_	_
21	striking	striking	JJ	JJ	_	22	amod	_	_
22	heterogeneity	heterogeneity	NN	NN	_	27	nsubjpass	_	_
23	of	of	IN	IN	_	25	case	_	_
24	clonal	clonal	JJ	JJ	_	25	amod	_	_
25	development	development	NN	NN	_	22	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	found	find	VBN	VBN	_	0	root	_	_
28	in	in	IN	IN	_	29	case	_	_
29	PMN	pmn	NN	NN	_	27	nmod	_	_
30	from	from	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	29	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	other	other	JJ	JJ	_	34	amod	_	_
34	MPD	mpd	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	27	punct	_	_
36	with	with	IN	IN	_	43	mark	_	_
37	up	up	IN	IN	_	39	dep	_	_
38	to	to	TO	TO	_	37	mwe	_	_
39	50	50	CD	CD	_	40	nummod	_	_
40	%	%	NN	NN	_	43	nsubj	_	_
41	of	of	IN	IN	_	42	case	_	_
42	them	they	PRP	PRP	_	40	nmod	_	_
43	expressing	express	VBG	VBG	_	27	advcl	_	_
44	a	a	DT	DT	_	46	det	_	_
45	polyclonal	polyclonal	JJ	JJ	_	46	amod	_	_
46	pattern	pattern	NN	NN	_	43	dobj	_	_
47	of	of	IN	IN	_	49	case	_	_
48	X	x	NN	NN	_	49	compound	_	_
49	inactivation	inactivation	NN	NN	_	46	nmod	_	_
50	.	.	.	.	_	27	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	6	nsubj	_	_
3	is	be	VBZ	VBZ	_	6	cop	_	_
4	a	a	DT	DT	_	6	det	_	_
5	critical	critical	JJ	JJ	_	6	amod	_	_
6	regulator	regulator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	granulocyte	granulocyte	NN	NN	_	10	compound	_	_
10	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
11	in	in	FW	FW	_	12	compound	_	_
12	vitro	vitro	FW	FW	_	10	advmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	beneficial	beneficial	JJ	JJ	_	3	amod	_	_
3	inflammation	inflammation	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	potentially	potentially	RB	RB	_	7	advmod	_	_
6	tissue-damaging	tissue-damaging	JJ	JJ	_	7	amod	_	_
7	granulocytes	granulocyte	NNS	NNS	_	8	nsubj	_	_
8	undergo	undergo	VBP	VBP	_	0	root	_	_
9	apoptosis	apoptosis	NN	NN	_	8	dobj	_	_
10	before	before	IN	IN	_	12	mark	_	_
11	being	be	VBG	VBG	_	12	auxpass	_	_
12	cleared	clear	VBN	VBN	_	8	advcl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	phagocytes	phagocyte	NNS	NNS	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	non-phlogistic	non-phlogistic	JJ	JJ	_	18	amod	_	_
18	manner	manner	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	rate	rate	NN	NN	_	17	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	neutrophils	neutrophil	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	eosinophils	eosinophil	NNS	NNS	_	12	conj	_	_
15	is	be	VBZ	VBZ	_	17	auxpass	_	_
16	greatly	greatly	RB	RB	_	17	advmod	_	_
17	accelerated	accelerate	VBN	VBN	_	3	ccomp	_	_
18	in	in	IN	IN	_	24	case	_	_
19	both	both	CC	CC	_	24	dep	_	_
20	a	a	DT	DT	_	24	det	_	_
21	rapid	rapid	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	concentration-dependent	concentration-dependent	JJ	JJ	_	21	conj	_	_
24	manner	manner	NN	NN	_	17	nmod	_	_
25	by	by	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	fungal	fungal	JJ	JJ	_	29	amod	_	_
28	metabolite	metabolite	NN	NN	_	29	compound	_	_
29	gliotoxin	gliotoxin	NN	NN	_	17	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	but	but	CC	CC	_	32	cc	_	_
32	not	not	RB	RB	_	29	cc	_	_
33	by	by	IN	IN	_	37	case	_	_
34	its	its	PRP$	PRP$	_	37	nmod:poss	_	_
35	inactive	inactive	JJ	JJ	_	37	amod	_	_
36	analog	analog	NN	NN	_	37	compound	_	_
37	methylthiogliotoxin	methylthiogliotoxin	NN	NN	_	29	conj	_	_
38	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	abolished	abolish	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	caspase	caspase	NN	NN	_	11	compound	_	_
10	inhibitor	inhibitor	NN	NN	_	11	compound	_	_
11	zVAD-fmk	zvad-fmk	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	correlated	correlate	VBN	VBN	_	6	conj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	inhibition	inhibition	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	factor-kappa	factor-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	6	punct	_	_
25	and	and	CC	CC	_	6	cc	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	mimicked	mimic	VBN	VBN	_	6	conj	_	_
28	by	by	IN	IN	_	33	case	_	_
29	a	a	DT	DT	_	33	det	_	_
30	cell	cell	NN	NN	_	33	compound	_	_
31	permeable	permeable	JJ	JJ	_	33	amod	_	_
32	inhibitory	inhibitory	JJ	JJ	_	33	amod	_	_
33	peptide	peptide	NN	NN	_	27	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	NF-kappaB	nf-kappab	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	33	punct	_	_
37	SN-50	sn-50	NN	NN	_	33	appos	_	_
38	;	;	:	:	_	33	punct	_	_
39	other	other	JJ	JJ	_	41	amod	_	_
40	NF-kappaB	nf-kappab	NN	NN	_	41	compound	_	_
41	inhibitors	inhibitor	NNS	NNS	_	33	conj	_	_
42	,	,	,	,	_	41	punct	_	_
43	curcumin	curcumin	NN	NN	_	41	appos	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	pyrrolidine	pyrrolidine	NN	NN	_	46	compound	_	_
46	dithiocarbamate	dithiocarbamate	NN	NN	_	43	conj	_	_
47	;	;	:	:	_	33	punct	_	_
48	and	and	CC	CC	_	33	cc	_	_
49	the	the	DT	DT	_	51	det	_	_
50	proteasome	proteasome	NN	NN	_	51	compound	_	_
51	inhibitor	inhibitor	NN	NN	_	33	conj	_	_
52	,	,	,	,	_	51	punct	_	_
53	MG-132	mg-132	NN	NN	_	51	appos	_	_
54	.	.	.	.	_	6	punct	_	_

1	Gliotoxin	gliotoxin	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	augmented	augment	VBD	VBD	_	0	root	_	_
4	dramatically	dramatically	RB	RB	_	3	advmod	_	_
5	the	the	DT	DT	_	12	det	_	_
6	early	early	JJ	JJ	_	12	amod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	2-6	2-6	CD	CD	_	9	nummod	_	_
9	h	h	NN	NN	_	12	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	pro-apoptotic	pro-apoptotic	JJ	JJ	_	12	amod	_	_
12	effects	effect	NNS	NNS	_	3	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	tumor	tumor	NN	NN	_	16	compound	_	_
15	necrosis	necrosis	NN	NN	_	16	compound	_	_
16	factor-alpha	factor-alpha	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	in	in	IN	IN	_	21	case	_	_
21	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
22	and	and	CC	CC	_	3	cc	_	_
23	unmasked	unmask	VBD	VBD	_	3	conj	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ability	ability	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	TNF-alpha	tnf-alpha	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	induce	induce	VB	VB	_	25	acl	_	_
30	eosinophil	eosinophil	NN	NN	_	31	compound	_	_
31	apoptosis	apoptosis	NN	NN	_	29	dobj	_	_
32	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	neutrophils	neutrophil	NNS	NNS	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	5	nsubj	_	_
5	caused	cause	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	gliotoxin-inhibitable	gliotoxin-inhibitable	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	an	a	DT	DT	_	12	det	_	_
11	inducible	inducible	JJ	JJ	_	12	amod	_	_
12	form	form	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	a	a	DT	DT	_	17	det	_	_
17	response	response	NN	NN	_	8	appos	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	underlie	underlie	VB	VB	_	17	acl:relcl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	ability	ability	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	22	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	delay	delay	VB	VB	_	22	acl	_	_
27	apoptosis	apoptosis	NN	NN	_	26	dobj	_	_
28	at	at	IN	IN	_	30	case	_	_
29	later	later	JJ	JJ	_	30	amod	_	_
30	times	time	NNS	NNS	_	26	nmod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	12-24	12-24	CD	CD	_	33	nummod	_	_
33	h	h	NN	NN	_	30	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	limit	limit	VB	VB	_	26	conj	_	_
37	its	its	PRP$	PRP$	_	40	nmod:poss	_	_
38	early	early	JJ	JJ	_	40	amod	_	_
39	killing	killing	NN	NN	_	40	compound	_	_
40	effect	effect	NN	NN	_	36	dobj	_	_
41	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	cycloheximide	cycloheximide	NN	NN	_	4	nsubj	_	_
4	displayed	display	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	similar	similar	JJ	JJ	_	7	amod	_	_
7	capacity	capacity	NN	NN	_	4	dobj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	enhance	enhance	VB	VB	_	7	acl	_	_
10	TNF-alpha	tnf-alpha	NN	NN	_	11	dep	_	_
11	induced	induce	VBN	VBN	_	13	amod	_	_
12	neutrophil	neutrophil	NN	NN	_	13	compound	_	_
13	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
14	even	even	RB	RB	_	17	advmod	_	_
15	at	at	IN	IN	_	17	case	_	_
16	time	time	NN	NN	_	17	compound	_	_
17	points	point	NNS	NNS	_	9	nmod	_	_
18	when	when	WRB	WRB	_	21	advmod	_	_
19	cycloheximide	cycloheximide	NN	NN	_	21	nsubj	_	_
20	alone	alone	RB	RB	_	19	advmod	_	_
21	had	have	VBD	VBD	_	17	acl:relcl	_	_
22	no	no	DT	DT	_	24	neg	_	_
23	pro-apoptotic	pro-apoptotic	JJ	JJ	_	24	amod	_	_
24	effect	effect	NN	NN	_	21	dobj	_	_
25	,	,	,	,	_	4	punct	_	_
26	suggesting	suggest	VBG	VBG	_	4	advcl	_	_
27	that	that	IN	IN	_	30	mark	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	30	nsubj	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	regulate	regulate	VB	VB	_	26	ccomp	_	_
31	the	the	DT	DT	_	32	det	_	_
32	production	production	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	protein	protein	NN	NN	_	36	compound	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	s	s	NNS	NNS	_	32	nmod	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	which	which	WDT	WDT	_	39	nsubj	_	_
39	protect	protect	VBP	VBP	_	36	acl:relcl	_	_
40	neutrophils	neutrophil	NNS	NNS	_	39	dobj	_	_
41	from	from	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	cytotoxic	cytotoxic	JJ	JJ	_	44	amod	_	_
44	effects	effect	NNS	NNS	_	39	nmod	_	_
45	of	of	IN	IN	_	46	case	_	_
46	TNF-alpha	tnf-alpha	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	shed	shed	VBD	VBD	_	0	root	_	_
4	light	light	NN	NN	_	3	dobj	_	_
5	on	on	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	biochemical	biochemical	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	molecular	molecular	JJ	JJ	_	7	conj	_	_
10	mechanisms	mechanism	NNS	NNS	_	3	nmod	_	_
11	regulating	regulate	VBG	VBG	_	10	acl	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	granulocyte	granulocyte	NN	NN	_	14	compound	_	_
14	apoptosis	apoptosis	NN	NN	_	11	dobj	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	,	,	,	,	_	3	punct	_	_
17	in	in	IN	IN	_	18	case	_	_
18	particular	particular	JJ	JJ	_	20	nmod	_	_
19	,	,	,	,	_	20	punct	_	_
20	indicate	indicate	VBP	VBP	_	3	conj	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	the	the	DT	DT	_	25	det	_	_
23	transcription	transcription	NN	NN	_	25	compound	_	_
24	factor	factor	NN	NN	_	25	compound	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	26	nsubj	_	_
26	plays	play	VBZ	VBZ	_	20	ccomp	_	_
27	a	a	DT	DT	_	29	det	_	_
28	crucial	crucial	JJ	JJ	_	29	amod	_	_
29	role	role	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	31	mark	_	_
31	regulating	regulate	VBG	VBG	_	26	advcl	_	_
32	the	the	DT	DT	_	36	det	_	_
33	physiological	physiological	JJ	JJ	_	36	amod	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	death	death	NN	NN	_	36	compound	_	_
36	pathway	pathway	NN	NN	_	31	dobj	_	_
37	in	in	IN	IN	_	38	case	_	_
38	granulocytes	granulocyte	NNS	NNS	_	36	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	Stat3-activation	stat3-activation	JJ	JJ	_	6	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Stat3-independent	stat3-independent	JJ	JJ	_	2	conj	_	_
5	BCL2	bcl2	NN	NN	_	6	compound	_	_
6	downregulation	downregulation	NN	NN	_	8	nsubj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	important	important	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	interleukin-6-induced	interleukin-6-induced	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	1A9-M	1a9-m	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	unique	unique	JJ	JJ	_	3	amod	_	_
3	subclone	subclone	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	10	case	_	_
5	a	a	DT	DT	_	10	det	_	_
6	bone	bone	NN	NN	_	10	compound	_	_
7	marrow-derived	marrow-derived	JJ	JJ	_	10	amod	_	_
8	stromal	stromal	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	3	nmod	_	_
11	,	,	,	,	_	3	punct	_	_
12	BMS2.4	bms2.4	NN	NN	_	3	appos	_	_
13	,	,	,	,	_	3	punct	_	_
14	produces	produce	VBZ	VBZ	_	0	root	_	_
15	soluble	soluble	JJ	JJ	_	16	amod	_	_
16	factors	factor	NNS	NNS	_	14	dobj	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	inhibit	inhibit	VBP	VBP	_	16	acl:relcl	_	_
19	proliferation	proliferation	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	several	several	JJ	JJ	_	22	amod	_	_
22	types	type	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	hematopoietic	hematopoietic	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	22	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	understanding	understanding	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	molecules	molecule	NNS	NNS	_	2	nmod	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	informative	informative	JJ	JJ	_	0	root	_	_
9	about	about	IN	IN	_	12	case	_	_
10	negative	negative	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	circuits	circuit	NNS	NNS	_	8	nmod	_	_
13	that	that	WDT	WDT	_	16	nsubj	_	_
14	can	can	MD	MD	_	16	aux	_	_
15	potentially	potentially	RB	RB	_	16	advmod	_	_
16	limit	limit	VB	VB	_	12	acl:relcl	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	formation	formation	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	cloning	clone	VBG	VBG	_	3	amod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	identify	identify	VB	VB	_	2	advcl	_	_
7	interleukin-6	interleukin-6	NN	NN	_	6	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	IL-6	il-6	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	as	as	IN	IN	_	13	case	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	factor	factor	NN	NN	_	6	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	suppressed	suppress	VBD	VBD	_	13	acl:relcl	_	_
16	growth	growth	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	pre-B-cell	pre-b-cell	NN	NN	_	21	compound	_	_
20	variant	variant	JJ	JJ	_	21	amod	_	_
21	line	line	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	1A9-M	1a9-m	NN	NN	_	21	appos	_	_
24	.	.	.	.	_	2	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IL-6	il-6	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	macrophage-differentiation	macrophage-differentiation	NN	NN	_	4	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	1A9-M	1a9-m	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	During	during	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	process	process	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	IL-6	il-6	NN	NN	_	6	nsubj	_	_
6	downregulated	downregulate	VBD	VBD	_	0	root	_	_
7	expression	expression	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	BCL2	bcl2	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	1A9-M	1a9-m	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	stimulated	stimulate	VBD	VBD	_	6	conj	_	_
15	BCL-XL	bcl-xl	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	6	punct	_	_
18	but	but	CC	CC	_	6	cc	_	_
19	had	have	VBD	VBD	_	6	conj	_	_
20	no	no	DT	DT	_	21	neg	_	_
21	effect	effect	NN	NN	_	19	dobj	_	_
22	on	on	IN	IN	_	25	case	_	_
23	p53	p53	NN	NN	_	25	compound	_	_
24	,	,	,	,	_	25	punct	_	_
25	Bax	bax	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	or	or	CC	CC	_	25	cc	_	_
28	Bak	bak	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	25	conj	_	_
31	.	.	.	.	_	6	punct	_	_

1	Mechanisms	mechanism	NNS	NNS	_	9	nsubjpass	_	_
2	for	for	IN	IN	_	3	case	_	_
3	transduction	transduction	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	IL-6-induced	il-6-induced	JJ	JJ	_	6	amod	_	_
6	signals	signal	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	then	then	RB	RB	_	9	advmod	_	_
9	evaluated	evaluate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	IL-6-stimulated	il-6-stimulated	JJ	JJ	_	13	amod	_	_
12	1A9-M	1a9-m	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Whereas	whereas	IN	IN	_	14	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transducer	transducer	NN	NN	_	14	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	activator	activator	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	transcription	transcription	NN	NN	_	4	nmod	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Stat3	stat3	NN	NN	_	4	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	phosphorylated	phosphorylate	VBN	VBN	_	19	advcl	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	activated	activate	VBN	VBN	_	14	conj	_	_
17	,	,	,	,	_	19	punct	_	_
18	there	there	EX	EX	_	19	expl	_	_
19	was	be	VBD	VBD	_	0	root	_	_
20	no	no	DT	DT	_	21	neg	_	_
21	effect	effect	NN	NN	_	19	nsubj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	either	either	CC	CC	_	24	cc:preconj	_	_
24	Stat1	stat1	NN	NN	_	21	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	Stat5	stat5	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BCL2	bcl2	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Stat3	stat3	NN	NN	_	4	conj	_	_
7	on	on	IN	IN	_	9	case	_	_
8	IL-6-induced	il-6-induced	JJ	JJ	_	9	amod	_	_
9	macrophage-differentiation	macrophage-differentiation	NN	NN	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	apoptosis	apoptosis	NN	NN	_	9	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	studied	study	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	1A9-M	1a9-m	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	expressing	express	VBG	VBG	_	16	acl	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	BCL2	bcl2	NN	NN	_	17	dobj	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	dominant-negative	dominant-negative	JJ	JJ	_	23	amod	_	_
23	form	form	NN	NN	_	19	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	Stat3	stat3	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	respectively	respectively	RB	RB	_	17	advmod	_	_
28	.	.	.	.	_	13	punct	_	_

1	IL-6-induced	il-6-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	9	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	but	but	CC	CC	_	5	cc	_	_
5	not	not	RB	RB	_	2	cc	_	_
6	macrophage-differentiation	macrophage-differentiation	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	blocked	block	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	continuously	continuously	RB	RB	_	12	advmod	_	_
12	expressed	express	VBN	VBN	_	13	amod	_	_
13	BCL2	bcl2	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	dominant-negative	dominant-negative	JJ	JJ	_	5	amod	_	_
3	form	form	NN	NN	_	5	compound	_	_
4	of	of	IN	IN	_	5	amod	_	_
5	Stat3	stat3	NN	NN	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	macrophage-differentiation	macrophage-differentiation	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	apoptosis	apoptosis	NN	NN	_	8	conj	_	_
11	induced	induce	VBN	VBN	_	8	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	IL-6	il-6	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	diminished	diminish	VBN	VBN	_	5	amod	_	_
4	Stat3	stat3	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	prevent	prevent	VB	VB	_	0	root	_	_
9	IL-6-induced	il-6-induced	JJ	JJ	_	10	amod	_	_
10	downregulation	downregulation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	BCL2	bcl2	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	activation	activation	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Stat3	stat3	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	essential	essential	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	IL-6-induced	il-6-induced	JJ	JJ	_	10	amod	_	_
10	macrophage-differentiation	macrophage-differentiation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	programmed	program	VBN	VBN	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	death	death	NN	NN	_	10	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	model	model	NN	NN	_	7	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Whereas	whereas	IN	IN	_	5	mark	_	_
2	overexpression	overexpression	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BCL2	bcl2	NN	NN	_	2	nmod	_	_
5	abrogates	abrogate	VBZ	VBZ	_	12	advcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	apoptotic	apoptotic	JJ	JJ	_	8	amod	_	_
8	response	response	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	12	punct	_	_
10	Stat3-independent	stat3-independent	JJ	JJ	_	11	amod	_	_
11	signals	signal	NNS	NNS	_	12	nsubj	_	_
12	appear	appear	VBP	VBP	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	downregulate	downregulate	VB	VB	_	12	xcomp	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	BCL2	bcl2	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Granulosa	granulosa	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	tumor	tumor	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ovary	ovary	NN	NN	_	3	nmod	_	_
7	.	.	.	.	_	3	punct	_	_

1	Immunohistochemical	immunohistochemical	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	low	low	JJ	JJ	_	6	amod	_	_
5	proliferative	proliferative	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	virtual	virtual	JJ	JJ	_	9	amod	_	_
9	absence	absence	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	mutation	mutation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	p53	p53	NN	NN	_	16	compound	_	_
15	tumor-suppressor	tumor-suppressor	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Because	because	IN	IN	_	24	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	24	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	immunohistochemistry	immunohistochemistry	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	diagnosis	diagnosis	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	granulosa	granulosa	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	tumor	tumor	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	GCT	gct	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	has	have	VBZ	VBZ	_	24	aux	_	_
21	not	not	RB	RB	_	24	neg	_	_
22	been	be	VBN	VBN	_	24	auxpass	_	_
23	fully	fully	RB	RB	_	24	advmod	_	_
24	explored	explore	VBN	VBN	_	42	advcl	_	_
25	,	,	,	,	_	42	punct	_	_
26	routinely	routinely	RB	RB	_	27	advmod	_	_
27	processed	process	VBN	VBN	_	33	amod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	formalin-fixed	formalin-fixed	JJ	JJ	_	27	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	paraffin-embedded	paraffin-embedded	JJ	JJ	_	29	dep	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	tissue	tissue	NN	NN	_	42	nsubjpass	_	_
34	from	from	IN	IN	_	36	case	_	_
35	11	11	CD	CD	_	36	nummod	_	_
36	GCT	gct	NN	NN	_	33	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	adult	adult	JJ	JJ	_	39	amod	_	_
39	type	type	NN	NN	_	36	appos	_	_
40	,	,	,	,	_	36	punct	_	_
41	was	be	VBD	VBD	_	42	auxpass	_	_
42	investigated	investigate	VBN	VBN	_	1	dep	_	_
43	immunohistochemically	immunohistochemically	RB	RB	_	42	advmod	_	_
44	(	(	-LRB-	-LRB-	_	46	punct	_	_
45	ABC	abc	NN	NN	_	46	compound	_	_
46	method	method	NN	NN	_	42	dep	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	with	with	IN	IN	_	51	case	_	_
49	a	a	DT	DT	_	51	det	_	_
50	broad	broad	JJ	JJ	_	51	amod	_	_
51	spectrum	spectrum	NN	NN	_	42	nmod	_	_
52	of	of	IN	IN	_	53	case	_	_
53	antibodies	antibody	NNS	NNS	_	51	nmod	_	_
54	against	against	IN	IN	_	56	case	_	_
55	various	various	JJ	JJ	_	56	amod	_	_
56	markers	marker	NNS	NNS	_	53	nmod	_	_
57	,	,	,	,	_	56	punct	_	_
58	including	include	VBG	VBG	_	59	case	_	_
59	p53	p53	NN	NN	_	56	nmod	_	_
60	and	and	CC	CC	_	59	cc	_	_
61	Ki-67	ki-67	NN	NN	_	59	conj	_	_
62	.	.	.	.	_	1	punct	_	_

1	All	all	DT	DT	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	tumors	tumor	NNS	NNS	_	1	nmod	_	_
5	exhibited	exhibit	VBD	VBD	_	0	root	_	_
6	typical	typical	JJ	JJ	_	7	amod	_	_
7	morphology	morphology	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	5	punct	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	limited	limit	VBN	VBN	_	5	dep	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ovary	ovary	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	stage	stage	NN	NN	_	10	dep	_	_
16	I	i	CD	CD	_	15	nummod	_	_
17	)	)	-RRB-	-RRB-	_	15	punct	_	_
18	,	,	,	,	_	5	punct	_	_
19	and	and	CC	CC	_	5	cc	_	_
20	7	7	CD	CD	_	21	nummod	_	_
21	cases	case	NNS	NNS	_	22	nsubj	_	_
22	followed	follow	VBD	VBD	_	5	conj	_	_
23	a	a	DT	DT	_	26	det	_	_
24	benign	benign	JJ	JJ	_	26	amod	_	_
25	clinical	clinical	JJ	JJ	_	26	amod	_	_
26	course	course	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	5	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	All	all	PDT	PDT	_	5	det:predet	_	_
4	the	the	DT	DT	_	5	det	_	_
5	tumors	tumor	NNS	NNS	_	6	nsubj	_	_
6	exhibited	exhibit	VBD	VBD	_	1	appos	_	_
7	strong	strong	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	vimentin	vimentin	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	most	most	JJS	JJS	_	15	amod	_	_
14	other	other	JJ	JJ	_	15	amod	_	_
15	antigens	antigen	NNS	NNS	_	23	nsubjpass	_	_
16	(	(	-LRB-	-LRB-	_	15	punct	_	_
17	including	include	VBG	VBG	_	20	case	_	_
18	smooth	smooth	JJ	JJ	_	20	amod	_	_
19	muscle	muscle	NN	NN	_	20	compound	_	_
20	actin	actin	NN	NN	_	15	nmod	_	_
21	)	)	-RRB-	-RRB-	_	15	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	expressed	express	VBN	VBN	_	6	conj	_	_
24	infrequently	infrequently	RB	RB	_	23	advmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	minority	minority	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	tumor	tumor	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	or	or	CC	CC	_	23	cc	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	at	at	IN	IN	_	34	case	_	_
34	all	all	DT	DT	_	23	conj	_	_
35	.	.	.	.	_	1	punct	_	_

1	Tumor	tumor	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	9	9	CD	CD	_	5	nummod	_	_
5	GCT	gct	NN	NN	_	2	nmod	_	_
6	expressed	express	VBD	VBD	_	0	root	_	_
7	inhibin	inhibin	NN	NN	_	8	compound	_	_
8	A	a	NN	NN	_	6	dobj	_	_
9	.	.	.	.	_	6	punct	_	_

1	All	all	PDT	PDT	_	3	det:predet	_	_
2	the	the	DT	DT	_	3	det	_	_
3	tumors	tumor	NNS	NNS	_	4	nsubj	_	_
4	exhibited	exhibit	VBD	VBD	_	0	root	_	_
5	very	very	RB	RB	_	6	advmod	_	_
6	low	low	JJ	JJ	_	8	amod	_	_
7	proliferative	proliferative	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	4	punct	_	_
10	fewer	fewer	JJR	JJR	_	12	advmod	_	_
11	than	than	IN	IN	_	12	advmod	_	_
12	10	10	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	20	nsubjpass	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	tumor	tumor	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	nuclei	nucleus	NNS	NNS	_	13	nmod	_	_
19	being	be	VBG	VBG	_	20	auxpass	_	_
20	stained	stain	VBN	VBN	_	4	advcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	antibody	antibody	NN	NN	_	24	compound	_	_
24	MIB-1	mib-1	NN	NN	_	20	nmod	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	Ki-67	ki-67	NN	NN	_	27	compound	_	_
27	antigen	antigen	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	antibody	antibody	NN	NN	_	4	nsubj	_	_
3	D07	d07	RB	RB	_	2	advmod	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	overexpression	overexpression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	p53	p53	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	tumor	tumor	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Clinical	clinical	JJ	JJ	_	2	amod	_	_
2	outcome	outcome	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	related	related	JJ	JJ	_	5	xcomp	_	_
9	to	to	TO	TO	_	11	case	_	_
10	immunophenotypic	immunophenotypic	JJ	JJ	_	11	amod	_	_
11	differences	difference	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	diagnosis	diagnosis	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	GCT	gct	NN	NN	_	4	nmod	_	_
7	should	should	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	based	base	VBN	VBN	_	1	appos	_	_
10	primarily	primarily	RB	RB	_	14	advmod	_	_
11	on	on	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	typical	typical	JJ	JJ	_	14	amod	_	_
14	morphology	morphology	NN	NN	_	9	nmod	_	_
15	revealed	reveal	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	18	case	_	_
17	conventional	conventional	JJ	JJ	_	18	amod	_	_
18	stains	stain	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	but	but	CC	CC	_	9	cc	_	_
21	additional	additional	JJ	JJ	_	23	amod	_	_
22	immunohistochemical	immunohistochemical	JJ	JJ	_	23	amod	_	_
23	staining	staining	NN	NN	_	46	nsubj	_	_
24	with	with	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	small	small	JJ	JJ	_	27	amod	_	_
27	panel	panel	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	selected	select	VBN	VBN	_	30	amod	_	_
30	antibodies	antibody	NNS	NNS	_	27	nmod	_	_
31	(	(	-LRB-	-LRB-	_	30	punct	_	_
32	for	for	IN	IN	_	33	case	_	_
33	example	example	NN	NN	_	36	nmod	_	_
34	,	,	,	,	_	36	punct	_	_
35	against	against	IN	IN	_	36	case	_	_
36	keratin	keratin	NN	NN	_	30	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	vimentin	vimentin	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	inhibin	inhibin	NN	NN	_	42	compound	_	_
42	A	a	NN	NN	_	36	conj	_	_
43	)	)	-RRB-	-RRB-	_	30	punct	_	_
44	may	may	MD	MD	_	46	aux	_	_
45	be	be	VB	VB	_	46	cop	_	_
46	helpful	helpful	JJ	JJ	_	9	conj	_	_
47	in	in	IN	IN	_	50	case	_	_
48	a	a	DT	DT	_	50	det	_	_
49	few	few	JJ	JJ	_	50	amod	_	_
50	cases	case	NNS	NNS	_	46	nmod	_	_
51	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	very	very	RB	RB	_	3	advmod	_	_
3	low	low	JJ	JJ	_	5	amod	_	_
4	proliferative	proliferative	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	15	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	8	det	_	_
8	lack	lack	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	overexpression	overexpression	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	p53	p53	NN	NN	_	13	compound	_	_
13	protein	protein	NN	NN	_	10	nmod	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	consistent	consistent	JJ	JJ	_	0	root	_	_
16	with	with	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	benign	benign	JJ	JJ	_	20	amod	_	_
19	clinical	clinical	JJ	JJ	_	20	amod	_	_
20	behavior	behavior	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	majority	majority	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	GCT	gct	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	Lactobacilli	lactobacilli	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	vaginal	vaginal	JJ	JJ	_	5	amod	_	_
4	host	host	NN	NN	_	5	compound	_	_
5	defense	defense	NN	NN	_	1	conj	_	_
6	:	:	:	:	_	1	punct	_	_
7	activation	activation	NN	NN	_	1	dep	_	_
8	of	of	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	human	human	JJ	JJ	_	17	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	17	compound	_	_
12	virus	virus	NN	NN	_	17	compound	_	_
13	type	type	NN	NN	_	17	compound	_	_
14	1	1	CD	CD	_	17	nummod	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	repeat	repeat	NN	NN	_	7	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	17	conj	_	_
21	,	,	,	,	_	17	punct	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	17	conj	_	_
24	.	.	.	.	_	1	punct	_	_

1	Lactobacilli	lactobacilli	NN	NN	_	12	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	component	component	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	vaginal	vaginal	JJ	JJ	_	9	amod	_	_
9	flora	flora	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	activate	activate	VB	VB	_	0	root	_	_
13	the	the	DT	DT	_	23	det	_	_
14	human	human	JJ	JJ	_	23	amod	_	_
15	immunodeficiency	immunodeficiency	NN	NN	_	23	compound	_	_
16	virus	virus	NN	NN	_	23	compound	_	_
17	(	(	-LRB-	-LRB-	_	23	punct	_	_
18	HIV	hiv	NN	NN	_	23	compound	_	_
19	)	)	-RRB-	-RRB-	_	23	punct	_	_
20	-1	-1	CD	CD	_	23	nummod	_	_
21	long	long	JJ	JJ	_	23	amod	_	_
22	terminal	terminal	JJ	JJ	_	23	amod	_	_
23	repeat	repeat	NN	NN	_	12	dobj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	LTR	ltr	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	31	case	_	_
28	the	the	DT	DT	_	31	det	_	_
29	Jurkat	jurkat	NN	NN	_	31	compound	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	lymphocyte	lymphocyte	NN	NN	_	23	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	THP-1	thp-1	NN	NN	_	36	compound	_	_
34	macrophage	macrophage	NN	NN	_	36	compound	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	31	conj	_	_
37	.	.	.	.	_	12	punct	_	_

1	Activation	activation	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	LTR	ltr	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Jurkat	jurkat	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	strongly	strongly	RB	RB	_	10	advmod	_	_
10	enhanced	enhance	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	12	case	_	_
12	vanadate	vanadate	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	inhibited	inhibit	VBN	VBN	_	10	conj	_	_
15	by	by	IN	IN	_	16	case	_	_
16	catalase	catalase	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	implicating	implicate	VBG	VBG	_	14	xcomp	_	_
19	H2O2	h2o2	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	activation	activation	NN	NN	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	THP-1	thp-1	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	occurred	occur	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	dep	_	_
11	absence	absence	NN	NN	_	13	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	vanadate	vanadate	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	unaffected	unaffect	VBN	VBN	_	8	conj	_	_
17	by	by	IN	IN	_	18	case	_	_
18	catalase	catalase	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	material	material	NN	NN	_	4	nsubj	_	_
4	partitioned	partition	VBD	VBD	_	0	root	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	phenol	phenol	NN	NN	_	8	compound	_	_
8	layer	layer	NN	NN	_	4	nmod	_	_
9	on	on	IN	IN	_	13	case	_	_
10	hot	hot	JJ	JJ	_	13	amod	_	_
11	aqueous	aqueous	JJ	JJ	_	13	amod	_	_
12	phenol	phenol	NN	NN	_	13	compound	_	_
13	extraction	extraction	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Lactobacilli	lactobacilli	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	increased	increase	VBD	VBD	_	0	root	_	_
4	tumor	tumor	NN	NN	_	6	compound	_	_
5	necrosis	necrosis	NN	NN	_	6	compound	_	_
6	factor-alpha	factor-alpha	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	interleukin-1beta	interleukin-1beta	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	6	conj	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	activated	activate	VBD	VBD	_	3	conj	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	THP-1	thp-1	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	increased	increase	VBD	VBD	_	3	conj	_	_
18	tumor	tumor	NN	NN	_	21	compound	_	_
19	necrosis	necrosis	NN	NN	_	21	compound	_	_
20	factor-alpha	factor-alpha	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	17	dobj	_	_
22	by	by	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	4	amod	_	_
2	vaginal	vaginal	JJ	JJ	_	4	amod	_	_
3	fluid	fluid	NN	NN	_	4	compound	_	_
4	specimens	specimen	NNS	NNS	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	comparable	comparable	JJ	JJ	_	7	amod	_	_
7	properties	property	NNS	NNS	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	correlated	correlate	VBD	VBD	_	7	acl:relcl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
13	bacterial	bacterial	JJ	JJ	_	14	amod	_	_
14	content	content	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	vaginal	vaginal	JJ	JJ	_	8	amod	_	_
8	fluid	fluid	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	agent	agent	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	s	s	NNS	NNS	_	5	nmod	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	derived	derive	VBN	VBN	_	12	acl	_	_
15	from	from	IN	IN	_	17	case	_	_
16	indigenous	indigenous	JJ	JJ	_	17	amod	_	_
17	bacteria	bacterium	NNS	NNS	_	14	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	activate	activate	VB	VB	_	17	acl:relcl	_	_
21	the	the	DT	DT	_	23	det	_	_
22	HIV-1	hiv-1	NN	NN	_	23	compound	_	_
23	LTR	ltr	NN	NN	_	20	dobj	_	_
24	,	,	,	,	_	23	punct	_	_
25	cytokine	cytokine	NN	NN	_	26	compound	_	_
26	production	production	NN	NN	_	23	conj	_	_
27	,	,	,	,	_	23	punct	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	NF-kappaB	nf-kappab	NN	NN	_	23	conj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	cells	cell	NNS	NNS	_	23	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	macrophage	macrophage	NN	NN	_	34	compound	_	_
34	lineage	lineage	NN	NN	_	31	nmod	_	_
35	,	,	,	,	_	20	punct	_	_
36	with	with	IN	IN	_	38	case	_	_
37	possible	possible	JJ	JJ	_	38	amod	_	_
38	influence	influence	NN	NN	_	20	nmod	_	_
39	on	on	IN	IN	_	41	case	_	_
40	vaginal	vaginal	JJ	JJ	_	41	amod	_	_
41	physiology	physiology	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	host	host	NN	NN	_	44	compound	_	_
44	defense	defense	NN	NN	_	41	conj	_	_
45	.	.	.	.	_	3	punct	_	_

1	Tuberculosis	tuberculosis	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	chronic	chronic	JJ	JJ	_	7	amod	_	_
4	hepatitis	hepatitis	NN	NN	_	7	compound	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	virus	virus	NN	NN	_	7	compound	_	_
7	infection	infection	NN	NN	_	1	conj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	Africans	african	NNS	NNS	_	1	nmod	_	_
10	and	and	CC	CC	_	1	cc	_	_
11	variation	variation	NN	NN	_	1	conj	_	_
12	in	in	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	vitamin	vitamin	NN	NN	_	17	compound	_	_
15	D	d	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	metabolite	metabolite	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	vitamin	vitamin	NN	NN	_	6	compound	_	_
6	D	d	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	1,25	1,25	CD	CD	_	10	nummod	_	_
9	dihydroxyvitamin	dihydroxyvitamin	NN	NN	_	10	compound	_	_
10	D3	d3	NN	NN	_	3	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	is	be	VBZ	VBZ	_	16	cop	_	_
13	an	a	DT	DT	_	16	det	_	_
14	important	important	JJ	JJ	_	16	amod	_	_
15	immunoregulatory	immunoregulatory	JJ	JJ	_	16	amod	_	_
16	hormone	hormone	NN	NN	_	0	root	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	16	punct	_	_
18	1	1	CD	CD	_	16	nummod	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	16	punct	_	_
20	.	.	.	.	_	16	punct	_	_

1	Its	its	PRP$	PRP$	_	2	nmod:poss	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	exerted	exert	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	interaction	interaction	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	vitamin	vitamin	NN	NN	_	11	compound	_	_
10	D	d	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	present	present	JJ	JJ	_	11	acl:relcl	_	_
16	on	on	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	activated	activate	VBN	VBN	_	21	amod	_	_
21	T	t	NN	NN	_	18	conj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	B	b	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	Variation	variation	NN	NN	_	9	nsubjpass	_	_
2	in	in	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	vitamin	vitamin	NN	NN	_	7	compound	_	_
5	D	d	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	1	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	typed	type	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	2015	2015	CD	CD	_	12	nummod	_	_
12	subjects	subject	NNS	NNS	_	9	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	large	large	JJ	JJ	_	16	amod	_	_
15	case-control	case-control	JJ	JJ	_	16	amod	_	_
16	studies	study	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	three	three	CD	CD	_	21	nummod	_	_
19	major	major	JJ	JJ	_	21	amod	_	_
20	infectious	infectious	JJ	JJ	_	21	amod	_	_
21	diseases	disease	NNS	NNS	_	16	nmod	_	_
22	:	:	:	:	_	21	punct	_	_
23	tuberculosis	tuberculosis	NN	NN	_	21	dep	_	_
24	,	,	,	,	_	23	punct	_	_
25	malaria	malaria	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	hepatitis	hepatitis	NN	NN	_	30	compound	_	_
29	B	b	NN	NN	_	30	compound	_	_
30	virus	virus	NN	NN	_	23	conj	_	_
31	.	.	.	.	_	9	punct	_	_

1	Homozygotes	homozygote	NNS	NNS	_	14	nsubj	_	_
2	for	for	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	polymorphism	polymorphism	NN	NN	_	1	nmod	_	_
5	at	at	IN	IN	_	6	case	_	_
6	codon	codon	NN	NN	_	4	nmod	_	_
7	352	352	CD	CD	_	6	nummod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	genotype	genotype	NN	NN	_	10	compound	_	_
10	tt	tt	NN	NN	_	1	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	were	be	VBD	VBD	_	14	aux	_	_
13	significantly	significantly	RB	RB	_	14	advmod	_	_
14	underrepresented	underrepresented	JJ	JJ	_	0	root	_	_
15	among	among	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	14	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	tuberculosis	tuberculosis	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	21	punct	_	_
20	chi2	chi2	NN	NN	_	21	nsubj	_	_
21	=	=	JJ	JJ	_	18	dep	_	_
22	6.22	6.22	CD	CD	_	21	dobj	_	_
23	,	,	,	,	_	21	punct	_	_
24	1	1	CD	CD	_	25	nummod	_	_
25	df	df	NN	NN	_	21	dep	_	_
26	,	,	,	,	_	21	punct	_	_
27	P	p	NN	NN	_	28	nsubj	_	_
28	=	=	JJ	JJ	_	21	parataxis	_	_
29	.01	.01	CD	CD	_	28	dobj	_	_
30	)	)	-RRB-	-RRB-	_	21	punct	_	_
31	and	and	CC	CC	_	18	cc	_	_
32	persistent	persistent	JJ	JJ	_	35	amod	_	_
33	hepatitis	hepatitis	NN	NN	_	35	compound	_	_
34	B	b	NN	NN	_	35	compound	_	_
35	infection	infection	NN	NN	_	18	conj	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	chi2	chi2	NN	NN	_	38	nsubj	_	_
38	=	=	JJ	JJ	_	35	dep	_	_
39	6.25	6.25	CD	CD	_	38	dobj	_	_
40	,	,	,	,	_	38	punct	_	_
41	1	1	CD	CD	_	42	nummod	_	_
42	df	df	NN	NN	_	38	dep	_	_
43	,	,	,	,	_	38	punct	_	_
44	P	p	NN	NN	_	45	nsubj	_	_
45	=	=	JJ	JJ	_	38	parataxis	_	_
46	.01	.01	CD	CD	_	45	dobj	_	_
47	)	)	-RRB-	-RRB-	_	38	punct	_	_
48	but	but	CC	CC	_	16	cc	_	_
49	not	not	RB	RB	_	51	neg	_	_
50	in	in	IN	IN	_	51	case	_	_
51	subjects	subject	NNS	NNS	_	16	conj	_	_
52	with	with	IN	IN	_	54	case	_	_
53	clinical	clinical	JJ	JJ	_	54	amod	_	_
54	malaria	malaria	NN	NN	_	51	nmod	_	_
55	compared	compare	VBN	VBN	_	59	case	_	_
56	with	with	IN	IN	_	59	case	_	_
57	the	the	DT	DT	_	59	det	_	_
58	other	other	JJ	JJ	_	59	amod	_	_
59	genotypes	genotype	NNS	NNS	_	14	advcl	_	_
60	.	.	.	.	_	14	punct	_	_

1	Therefore	therefore	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	genetic	genetic	JJ	JJ	_	5	amod	_	_
5	variant	variant	NN	NN	_	19	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	8	nsubj	_	_
8	predisposes	predispose	VBZ	VBZ	_	5	acl:relcl	_	_
9	to	to	TO	TO	_	13	case	_	_
10	low	low	JJ	JJ	_	13	amod	_	_
11	bone	bone	NN	NN	_	13	compound	_	_
12	mineral	mineral	JJ	JJ	_	13	amod	_	_
13	density	density	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	populations	population	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	may	may	MD	MD	_	19	aux	_	_
19	confer	confer	VB	VB	_	0	root	_	_
20	resistance	resistance	NN	NN	_	19	dobj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	certain	certain	JJ	JJ	_	24	amod	_	_
23	infectious	infectious	JJ	JJ	_	24	amod	_	_
24	diseases	disease	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	High-level	high-level	JJ	JJ	_	2	amod	_	_
2	replication	replication	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	human	human	JJ	JJ	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	virus	virus	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	thymocytes	thymocyte	NNS	NNS	_	6	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	through	through	IN	IN	_	13	case	_	_
13	interaction	interaction	NN	NN	_	11	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	thymic	thymic	JJ	JJ	_	17	amod	_	_
16	epithelial	epithelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	interaction	interaction	NN	NN	_	20	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	infected	infected	JJ	JJ	_	9	amod	_	_
9	thymocytes	thymocyte	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	14	case	_	_
11	autologous	autologous	JJ	JJ	_	14	amod	_	_
12	thymic	thymic	JJ	JJ	_	14	amod	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TEC	tec	NNS	NNS	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	is	be	VBZ	VBZ	_	20	cop	_	_
19	a	a	DT	DT	_	20	det	_	_
20	prerequisite	prerequisite	NN	NN	_	4	ccomp	_	_
21	for	for	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	high	high	JJ	JJ	_	24	amod	_	_
24	level	level	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	34	case	_	_
26	human	human	JJ	JJ	_	29	amod	_	_
27	immunodeficiency	immunodeficiency	NN	NN	_	29	compound	_	_
28	virus	virus	NN	NN	_	29	compound	_	_
29	type	type	NN	NN	_	34	compound	_	_
30	1	1	CD	CD	_	29	nummod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	HIV-1	hiv-1	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	replication	replication	NN	NN	_	24	nmod	_	_
35	in	in	IN	IN	_	36	case	_	_
36	thymocytes	thymocyte	NNS	NNS	_	34	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	M.Rothe	M.Rothe	NNP	NNP	_	20	dep	_	_
39	,	,	,	,	_	38	punct	_	_
40	L.Chene	L.Chene	NNP	NNP	_	38	conj	_	_
41	,	,	,	,	_	38	punct	_	_
42	M.Nugeyre	M.Nugeyre	NNP	NNP	_	38	conj	_	_
43	,	,	,	,	_	38	punct	_	_
44	F.Barre-Sinoussi	F.Barre-Sinoussi	NNP	NNP	_	38	conj	_	_
45	,	,	,	,	_	38	punct	_	_
46	and	and	CC	CC	_	38	cc	_	_
47	N.Israel	N.Israel	NNP	NNP	_	38	conj	_	_
48	,	,	,	,	_	38	punct	_	_
49	J.Virol.72	J.Virol.72	NNP	NNP	_	38	dep	_	_
50	:	:	:	:	_	38	punct	_	_
51	5852-5861	5852-5861	CD	CD	_	38	dep	_	_
52	,	,	,	,	_	38	punct	_	_
53	1998	1998	CD	CD	_	38	dep	_	_
54	)	)	-RRB-	-RRB-	_	38	punct	_	_
55	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	activation	activation	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	HIV	hiv	NN	NN	_	9	compound	_	_
9	replication	replication	NN	NN	_	6	nmod	_	_
10	takes	take	VBZ	VBZ	_	2	ccomp	_	_
11	place	place	NN	NN	_	10	dobj	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	10	nmod	_	_
16	through	through	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	Rel/NF-kappaB	rel/nf-kappab	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	first	first	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	an	a	DT	DT	_	7	det	_	_
6	HIV-1	hiv-1	NN	NN	_	7	compound	_	_
7	provirus	provirus	NN	NN	_	14	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	SF-2	sf-2	NN	NN	_	10	compound	_	_
10	strain	strain	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	effectively	effectively	RB	RB	_	14	advmod	_	_
14	replicates	replicate	VBZ	VBZ	_	3	ccomp	_	_
15	in	in	IN	IN	_	16	case	_	_
16	thymocytes	thymocyte	NNS	NNS	_	14	nmod	_	_
17	cocultured	coculture	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	TEC	tec	NNS	NNS	_	17	nmod	_	_
20	whereas	whereas	IN	IN	_	14	dep	_	_
21	this	this	DT	DT	_	22	det	_	_
22	provirus	provirus	NN	NN	_	29	nsubj	_	_
23	,	,	,	,	_	22	punct	_	_
24	with	with	IN	IN	_	27	mark	_	_
25	kappaB	kappab	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	27	nsubj	_	_
27	deleted	delete	VBN	VBN	_	22	acl:relcl	_	_
28	,	,	,	,	_	22	punct	_	_
29	fails	fail	VBZ	VBZ	_	14	parataxis	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	replicate	replicate	VB	VB	_	29	xcomp	_	_
32	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	complexes	complex	NNS	NNS	_	10	nsubjpass	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	constitutively	constitutively	RB	RB	_	10	advmod	_	_
10	found	find	VBN	VBN	_	3	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	nuclei	nucleus	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
16	either	either	CC	CC	_	18	cc:preconj	_	_
17	freshly	freshly	RB	RB	_	18	advmod	_	_
18	isolated	isolate	VBN	VBN	_	15	dep	_	_
19	from	from	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	thymus	thymus	NN	NN	_	18	nmod	_	_
22	or	or	CC	CC	_	18	cc	_	_
23	maintained	maintain	VBN	VBN	_	18	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	coculture	coculture	NN	NN	_	23	nmod	_	_
26	with	with	IN	IN	_	30	case	_	_
27	autologous	autologous	JJ	JJ	_	30	amod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	heterologous	heterologous	JJ	JJ	_	27	conj	_	_
30	TEC	tec	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	prevalent	prevalent	JJ	JJ	_	3	amod	_	_
3	complex	complex	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	the	the	DT	DT	_	7	det	_	_
6	heterodimer	heterodimer	NN	NN	_	7	compound	_	_
7	p50-p65	p50-p65	NN	NN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	tightly	tightly	RB	RB	_	5	advmod	_	_
5	correlated	correlate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	long	long	JJ	JJ	_	14	amod	_	_
13	terminal	terminal	JJ	JJ	_	14	amod	_	_
14	repeat	repeat	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	LTR	ltr	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HIV-1	hiv-1	NN	NN	_	14	nmod	_	_
20	transfected	transfect	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	22	case	_	_
22	thymocytes	thymocyte	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cotransfection	cotransfection	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	LTR	ltr	NN	NN	_	2	nmod	_	_
6	with	with	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	mutated	mutate	VBN	VBN	_	10	amod	_	_
9	IkappaBalpha	ikappabalpha	NN	NN	_	10	compound	_	_
10	molecule	molecule	NN	NN	_	2	nmod	_	_
11	formally	formally	RB	RB	_	12	advmod	_	_
12	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	LTR	ltr	NN	NN	_	15	compound	_	_
15	transactivation	transactivation	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	regulated	regulate	VBN	VBN	_	12	ccomp	_	_
18	by	by	IN	IN	_	19	case	_	_
19	members	member	NNS	NNS	_	17	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	Rel/NF-kappaB	rel/nf-kappab	NN	NN	_	23	compound	_	_
23	family	family	NN	NN	_	19	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	thymocytes	thymocyte	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	tumor	tumor	NN	NN	_	7	compound	_	_
6	necrosis	necrosis	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	3	ccomp	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	TNF	tnf	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	to	to	TO	TO	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	lesser	lesser	JJR	JJR	_	15	amod	_	_
15	extent	extent	NN	NN	_	26	nmod	_	_
16	interleukin-1	interleukin-1	NN	NN	_	26	nsubj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL-1	il-1	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	16	punct	_	_
21	secreted	secrete	VBN	VBN	_	16	acl	_	_
22	within	within	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	coculture	coculture	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	16	punct	_	_
26	induce	induce	VBP	VBP	_	7	conj	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	26	dobj	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	a	a	DT	DT	_	33	det	_	_
31	correlative	correlative	JJ	JJ	_	33	amod	_	_
32	LTR	ltr	NN	NN	_	33	compound	_	_
33	transactivation	transactivation	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	IL-7	il-7	NN	NN	_	19	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	6	det	_	_
5	crucial	crucial	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	2	appos	_	_
7	for	for	IN	IN	_	8	case	_	_
8	thymopoiesis	thymopoiesis	NN	NN	_	6	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	secreted	secrete	VBN	VBN	_	6	acl:relcl	_	_
12	mainly	mainly	RB	RB	_	14	advmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	TEC	tec	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	necessary	necessary	JJ	JJ	_	19	amod	_	_
19	cofactor	cofactor	NN	NN	_	0	root	_	_
20	for	for	IN	IN	_	22	case	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	elicited	elicit	VBN	VBN	_	22	acl	_	_
24	by	by	IN	IN	_	25	case	_	_
25	TNF	tnf	NN	NN	_	23	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	IL-1	il-1	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	19	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	22	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	required	require	VBN	VBN	_	8	acl	_	_
11	for	for	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	level	level	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HIV	hiv	NN	NN	_	17	compound	_	_
17	replication	replication	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	thymocytes	thymocyte	NNS	NNS	_	17	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	regulated	regulate	VBN	VBN	_	5	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	specific	specific	JJ	JJ	_	26	amod	_	_
26	manner	manner	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	thymic	thymic	JJ	JJ	_	30	amod	_	_
30	microenvironment	microenvironment	NN	NN	_	22	nmod	_	_
31	which	which	WDT	WDT	_	32	nsubj	_	_
32	provides	provide	VBZ	VBZ	_	30	acl:relcl	_	_
33	the	the	DT	DT	_	35	det	_	_
34	necessary	necessary	JJ	JJ	_	35	amod	_	_
35	cytokines	cytokine	NNS	NNS	_	32	dobj	_	_
36	:	:	:	:	_	35	punct	_	_
37	TNF	tnf	NN	NN	_	35	dep	_	_
38	,	,	,	,	_	37	punct	_	_
39	IL-1	il-1	NN	NN	_	37	conj	_	_
40	,	,	,	,	_	37	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	IL-7	il-7	NN	NN	_	37	conj	_	_
43	.	.	.	.	_	5	punct	_	_

1	Cutting	cutting	JJ	JJ	_	2	amod	_	_
2	edge	edge	NN	NN	_	0	root	_	_
3	:	:	:	:	_	2	punct	_	_
4	dominant	dominant	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	2	dep	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Ile50Val	ile50val	NN	NN	_	8	compound	_	_
8	variant	variant	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	IL-4	il-4	NN	NN	_	14	compound	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	alpha-chain	alpha-chain	NN	NN	_	8	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	IgE	ige	NN	NN	_	17	compound	_	_
17	synthesis	synthesis	NN	NN	_	5	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	variants	variant	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	IL-4R	il-4r	NN	NN	_	10	compound	_	_
6	alpha-chain	alpha-chain	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	10	punct	_	_
8	IL-4Ralpha	il-4ralpha	NN	NN	_	10	compound	_	_
9	)	)	-RRB-	-RRB-	_	10	punct	_	_
10	gene	gene	NN	NN	_	2	nmod	_	_
11	have	have	VBP	VBP	_	14	aux	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	recently	recently	RB	RB	_	14	advmod	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	16	case	_	_
16	association	association	NN	NN	_	14	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	different	different	JJ	JJ	_	20	amod	_	_
19	atopic	atopic	JJ	JJ	_	20	amod	_	_
20	disorders	disorder	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	12	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	etiological	etiological	JJ	JJ	_	5	amod	_	_
5	relationship	relationship	NN	NN	_	2	dobj	_	_
6	between	between	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	variants	variant	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	analyzed	analyze	VBD	VBD	_	0	root	_	_
13	responsiveness	responsiveness	NN	NN	_	12	dobj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	IL-4	il-4	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	transfectants	transfectant	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	four	four	CD	CD	_	20	nummod	_	_
20	kinds	kind	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IL-4Ralpha	il-4ralpha	NN	NN	_	20	nmod	_	_
23	carrying	carry	VBG	VBG	_	20	dep	_	_
24	either	either	CC	CC	_	25	cc:preconj	_	_
25	Val	val	NN	NN	_	23	dobj	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	Ile	ile	NN	NN	_	25	conj	_	_
28	at	at	IN	IN	_	29	case	_	_
29	50	50	CD	CD	_	23	nmod	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	either	either	CC	CC	_	32	cc:preconj	_	_
32	Gln	gln	NN	NN	_	23	conj	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	Arg	arg	NN	NN	_	32	conj	_	_
35	at	at	IN	IN	_	36	case	_	_
36	551	551	CD	CD	_	32	nmod	_	_
37	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	substitution	substitution	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Ile	ile	NN	NN	_	2	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	Val	val	NN	NN	_	2	nmod	_	_
7	augmented	augment	VBD	VBD	_	0	root	_	_
8	STAT6	stat6	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	proliferation	proliferation	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	9	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Iepsilon	iepsilon	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	9	nmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	IL-4	il-4	NN	NN	_	9	nmod	_	_
22	,	,	,	,	_	7	punct	_	_
23	whereas	whereas	IN	IN	_	7	dep	_	_
24	that	that	DT	DT	_	31	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	Arg	arg	NN	NN	_	24	nmod	_	_
27	for	for	IN	IN	_	28	case	_	_
28	Gln	gln	NN	NN	_	24	nmod	_	_
29	did	do	VBD	VBD	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	change	change	VB	VB	_	7	parataxis	_	_
32	these	these	DT	DT	_	34	det	_	_
33	IL-4	il-4	NN	NN	_	34	compound	_	_
34	signals	signal	NNS	NNS	_	31	dobj	_	_
35	.	.	.	.	_	7	punct	_	_

1	Arg551	arg551	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	atopic	atopic	JJ	JJ	_	7	amod	_	_
7	asthma	asthma	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	Japanese	japanese	JJ	JJ	_	11	amod	_	_
11	population	population	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	CD23	cd23	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	9	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	IgE	ige	NN	NN	_	5	compound	_	_
5	synthesis	synthesis	NN	NN	_	2	conj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IL-4	il-4	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	aux	_	_
9	augmented	augmented	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	Ile50-bearing	ile50-bearing	JJ	JJ	_	12	amod	_	_
12	PBMC	pbmc	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	compared	compare	VBN	VBN	_	16	case	_	_
15	with	with	IN	IN	_	16	case	_	_
16	those	those	DT	DT	_	9	advcl	_	_
17	bearing	bear	VBG	VBG	_	16	acl	_	_
18	Val50	val50	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Taken	take	VBN	VBN	_	0	root	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	1	punct	_	_
4	substitution	substitution	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Arg551	arg551	NN	NN	_	4	nmod	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	enhance	enhance	VB	VB	_	1	parataxis	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-4	il-4	NN	NN	_	12	compound	_	_
12	signal	signal	NN	NN	_	9	dobj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	generation	generation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	germline	germline	NN	NN	_	18	compound	_	_
17	epsilon	epsilon	NN	NN	_	18	compound	_	_
18	transcript	transcript	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	whereas	whereas	IN	IN	_	9	dep	_	_
21	the	the	DT	DT	_	22	det	_	_
22	substitution	substitution	NN	NN	_	25	nsubj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Ile50	ile50	NN	NN	_	22	nmod	_	_
25	contributes	contribute	VBZ	VBZ	_	9	parataxis	_	_
26	to	to	TO	TO	_	27	case	_	_
27	enhancement	enhancement	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	IgE	ige	NN	NN	_	30	compound	_	_
30	synthesis	synthesis	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	3	case	_	_
3	repression	repression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	IL-2	il-2	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	anergic	anergic	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	clonal	clonal	JJ	JJ	_	5	amod	_	_
5	anergy	anergy	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cell	cell	NN	NN	_	2	nmod	_	_
10	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	secretion	secretion	NN	NN	_	10	dobj	_	_
13	because	because	IN	IN	_	16	case	_	_
14	of	of	IN	IN	_	13	mwe	_	_
15	the	the	DT	DT	_	16	det	_	_
16	development	development	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	proximal	proximal	JJ	JJ	_	22	amod	_	_
20	signal	signal	NN	NN	_	22	compound	_	_
21	transduction	transduction	NN	NN	_	22	compound	_	_
22	defect	defect	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	Fusion	fusion	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	anergic	anergic	JJ	JJ	_	6	amod	_	_
4	murine	murine	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	to	to	TO	TO	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	Jurkat	jurkat	NN	NN	_	12	compound	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	leukemia	leukemia	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	1	nmod	_	_
13	and	and	CC	CC	_	1	cc	_	_
14	formation	formation	NN	NN	_	1	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	heterokaryons	heterokaryon	NNS	NNS	_	14	nmod	_	_
17	failed	fail	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	result	result	VB	VB	_	17	xcomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	a	a	DT	DT	_	22	det	_	_
22	complementation	complementation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	this	this	DT	DT	_	26	det	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	defect	defect	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	restoration	restoration	NN	NN	_	22	conj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	murine	murine	JJ	JJ	_	33	amod	_	_
31	IL-2	il-2	NN	NN	_	33	compound	_	_
32	mRNA	mrna	NN	NN	_	33	compound	_	_
33	inducibility	inducibility	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	Instead	instead	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transduction	transduction	NN	NN	_	10	nsubj	_	_
5	to	to	TO	TO	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	4	nmod	_	_
10	became	become	VBD	VBD	_	0	root	_	_
11	disrupted	disrupt	VBN	VBN	_	10	xcomp	_	_
12	.	.	.	.	_	10	punct	_	_

1	Heterokaryons	heterokaryon	NNS	NNS	_	17	nsubj	_	_
2	formed	form	VBN	VBN	_	1	acl	_	_
3	by	by	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	fusion	fusion	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	anergic	anergic	JJ	JJ	_	10	amod	_	_
8	murine	murine	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	to	to	TO	TO	_	15	case	_	_
12	normal	normal	JJ	JJ	_	15	amod	_	_
13	murine	murine	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	failed	fail	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	accumulate	accumulate	VB	VB	_	17	xcomp	_	_
20	intracellular	intracellular	JJ	JJ	_	22	amod	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	protein	protein	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	response	response	NN	NN	_	26	dep	_	_
25	to	to	TO	TO	_	26	case	_	_
26	stimulation	stimulation	NN	NN	_	17	nmod	_	_
27	either	either	CC	CC	_	30	cc:preconj	_	_
28	with	with	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	combination	combination	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	35	case	_	_
32	CD3	cd3	NN	NN	_	35	compound	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	CD28	cd28	NN	NN	_	32	conj	_	_
35	mAbs	mab	NNS	NNS	_	30	nmod	_	_
36	or	or	CC	CC	_	30	cc	_	_
37	with	with	IN	IN	_	38	case	_	_
38	ionomycin	ionomycin	NN	NN	_	30	conj	_	_
39	plus	plus	CC	CC	_	38	cc	_	_
40	a	a	DT	DT	_	45	det	_	_
41	protein	protein	NN	NN	_	43	nmod:npmod	_	_
42	kinase	kinase	NN	NN	_	43	nmod:npmod	_	_
43	C-activating	c-activating	JJ	JJ	_	45	amod	_	_
44	phorbol	phorbol	NN	NN	_	45	compound	_	_
45	ester	ester	NN	NN	_	38	conj	_	_
46	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	argue	argue	VBP	VBP	_	0	root	_	_
4	against	against	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	loss-of-function	loss-of-function	JJ	JJ	_	8	amod	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	defect	defect	NN	NN	_	3	nmod	_	_
9	as	as	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	sole	sole	JJ	JJ	_	12	amod	_	_
12	basis	basis	NN	NN	_	8	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	clonal	clonal	JJ	JJ	_	16	amod	_	_
15	anergy	anergy	NN	NN	_	16	compound	_	_
16	induction	induction	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	3	cc	_	_
18	document	document	VBP	VBP	_	3	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	dominant-acting	dominant-acting	JJ	JJ	_	25	amod	_	_
24	repressor	repressor	NN	NN	_	25	compound	_	_
25	molecule	molecule	NN	NN	_	20	nmod	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	inhibits	inhibit	VBZ	VBZ	_	25	acl:relcl	_	_
28	signal	signal	NN	NN	_	29	compound	_	_
29	transduction	transduction	NN	NN	_	27	dobj	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	IL-2	il-2	NN	NN	_	33	compound	_	_
33	gene	gene	NN	NN	_	29	nmod	_	_
34	within	within	IN	IN	_	38	case	_	_
35	viable	viable	JJ	JJ	_	38	amod	_	_
36	anergic	anergic	JJ	JJ	_	38	amod	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	29	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Fas	fas	NN	NN	_	3	compound	_	_
2	ligand	ligand	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	9	nsubjpass	_	_
4	in	in	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	NK	nk	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	redox	redox	NN	NN	_	9	nmod	_	_
12	through	through	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	calcineurin-nuclear	calcineurin-nuclear	JJ	JJ	_	15	amod	_	_
15	factors	factor	NNS	NNS	_	9	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	activated	activate	VBN	VBN	_	19	dep	_	_
18	T	t	NN	NN	_	19	nmod:npmod	_	_
19	cell-dependent	cell-dependent	JJ	JJ	_	20	amod	_	_
20	pathway	pathway	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Fas	fas	NN	NN	_	2	compound	_	_
2	ligand	ligand	NN	NN	_	10	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	FasL	fasl	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	on	on	IN	IN	_	8	case	_	_
7	cytotoxic	cytotoxic	JJ	JJ	_	8	amod	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	important	important	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	12	mark	_	_
12	mediating	mediate	VBG	VBG	_	10	advcl	_	_
13	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	activated	activate	VBN	VBN	_	16	amod	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	other	other	JJ	JJ	_	20	amod	_	_
19	target	target	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	reported	report	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	NK	nk	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	functions	function	NNS	NNS	_	21	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	such	such	JJ	JJ	_	11	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	proliferation	proliferation	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	death	death	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	killing	killing	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	11	conj	_	_
19	,	,	,	,	_	7	punct	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	subject	subject	JJ	JJ	_	3	ccomp	_	_
22	to	to	TO	TO	_	23	case	_	_
23	regulation	regulation	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	27	case	_	_
25	cellular	cellular	JJ	JJ	_	27	amod	_	_
26	redox	redox	NN	NN	_	27	compound	_	_
27	status	status	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	18	mark	_	_
6	expression	expression	NN	NN	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	FasL	fasl	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	mRNA	mrna	NN	NN	_	9	conj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	NK	nk	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	regulated	regulate	VBN	VBN	_	4	ccomp	_	_
19	by	by	IN	IN	_	20	case	_	_
20	redox	redox	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Ligation	ligation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD16	cd16	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	7	case	_	_
5	IL-2-preactivated	il-2-preactivated	JJ	JJ	_	7	amod	_	_
6	NK	nk	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	reduction	reduction	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
13	peroxide	peroxide	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	10	nmod	_	_
15	as	as	RB	RB	_	10	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	induction	induction	NN	NN	_	10	conj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	FasL	fasl	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	CD16-induced	cd16-induced	JJ	JJ	_	4	amod	_	_
3	FasL	fasl	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	suppressed	suppress	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	oxidative	oxidative	JJ	JJ	_	9	amod	_	_
9	stress	stress	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	13	case	_	_
12	thiol	thiol	NN	NN	_	13	compound	_	_
13	deprivation	deprivation	NN	NN	_	9	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	treatment	treatment	NN	NN	_	13	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	hydrogen	hydrogen	NN	NN	_	18	compound	_	_
18	peroxide	peroxide	NN	NN	_	15	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	H2O2	h2o2	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	6	punct	_	_

1	Addition	addition	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	thiol-reducing	thiol-reducing	JJ	JJ	_	4	amod	_	_
4	compounds	compound	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	such	such	JJ	JJ	_	8	case	_	_
7	as	as	IN	IN	_	6	mwe	_	_
8	L-cystine	l-cystine	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	2-ME	2-me	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	N-acetyl	n-acetyl	JJ	JJ	_	14	amod	_	_
14	cysteine	cysteine	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	4	punct	_	_
16	restored	restore	VBD	VBD	_	0	root	_	_
17	FasL	fasl	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CD16	cd16	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
7	requires	require	VBZ	VBZ	_	3	ccomp	_	_
8	cellular	cellular	JJ	JJ	_	10	amod	_	_
9	reducing	reduce	VBG	VBG	_	10	amod	_	_
10	status	status	NN	NN	_	7	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	FasL	fasl	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	7	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	NK	nk	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	9	mark	_	_
2	FasL	fasl	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	9	nsubjpass	_	_
5	following	follow	VBG	VBG	_	7	case	_	_
6	CD16	cd16	NN	NN	_	7	compound	_	_
7	cross-linking	cross-linking	NN	NN	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	22	advcl	_	_
10	by	by	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	NF	nf	NN	NN	_	16	compound	_	_
13	of	of	IN	IN	_	16	amod	_	_
14	activated	activate	VBN	VBN	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	NFAT	nfat	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	22	punct	_	_
21	we	we	PRP	PRP	_	22	nsubj	_	_
22	examined	examine	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	oxidative	oxidative	JJ	JJ	_	27	amod	_	_
27	stresses	stress	NNS	NNS	_	24	nmod	_	_
28	on	on	IN	IN	_	30	case	_	_
29	NFAT	nfat	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	22	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	both	both	CC	CC	_	9	cc:preconj	_	_
8	thiol	thiol	NN	NN	_	9	compound	_	_
9	insufficiency	insufficiency	NN	NN	_	13	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	H2O2	h2o2	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	9	conj	_	_
13	suppressed	suppress	VBD	VBD	_	5	ccomp	_	_
14	DNA-binding	dna-binding	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NFAT	nfat	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	addition	addition	NN	NN	_	24	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	thiol-reducing	thiol-reducing	JJ	JJ	_	23	amod	_	_
23	compounds	compound	NNS	NNS	_	20	nmod	_	_
24	reversed	reverse	VBD	VBD	_	13	conj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	even	even	RB	RB	_	27	advmod	_	_
27	enhanced	enhance	VBD	VBD	_	24	conj	_	_
28	it	it	PRP	PRP	_	24	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	these	these	DT	DT	_	5	det	_	_
4	oxidative	oxidative	JJ	JJ	_	5	amod	_	_
5	stresses	stress	NNS	NNS	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	activity	activity	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	calcineurin	calcineurin	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	13	det	_	_
12	serine/threonine	serine/threonine	NN	NN	_	13	compound	_	_
13	phosphatase	phosphatase	NN	NN	_	9	appos	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	regulates	regulate	VBZ	VBZ	_	13	acl:relcl	_	_
16	NFAT	nfat	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	suppression	suppression	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	calcineurin	calcineurin	NN	NN	_	10	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NFAT	nfat	NN	NN	_	7	conj	_	_
10	activation	activation	NN	NN	_	5	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	a	a	DT	DT	_	13	det	_	_
13	mechanism	mechanism	NN	NN	_	3	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	18	nmod	_	_
16	oxidative	oxidative	JJ	JJ	_	17	amod	_	_
17	stress	stress	NN	NN	_	18	nsubj	_	_
18	inhibits	inhibit	VBZ	VBZ	_	13	acl:relcl	_	_
19	FasL	fasl	NN	NN	_	20	compound	_	_
20	induction	induction	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	activated	activate	VBN	VBN	_	24	amod	_	_
23	NK	nk	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	further	further	RB	RB	_	27	advmod	_	_
27	support	support	VBP	VBP	_	3	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	hypothesis	hypothesis	NN	NN	_	27	dobj	_	_
30	that	that	IN	IN	_	35	mark	_	_
31	thiol-reducing	thiol-reducing	JJ	JJ	_	32	amod	_	_
32	compounds	compound	NNS	NNS	_	35	nsubjpass	_	_
33	might	might	MD	MD	_	35	aux	_	_
34	be	be	VB	VB	_	35	auxpass	_	_
35	required	require	VBN	VBN	_	29	ccomp	_	_
36	for	for	IN	IN	_	37	case	_	_
37	maintenance	maintenance	NN	NN	_	35	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	optimal	optimal	JJ	JJ	_	41	amod	_	_
40	NK	nk	NN	NN	_	41	compound	_	_
41	functions	function	NNS	NNS	_	37	nmod	_	_
42	under	under	IN	IN	_	45	case	_	_
43	physiologic	physiologic	JJ	JJ	_	45	amod	_	_
44	oxidative	oxidative	JJ	JJ	_	45	amod	_	_
45	conditions	condition	NNS	NNS	_	35	nmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	Cross-linking	cross-linking	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD44	cd44	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	7	case	_	_
5	rheumatoid	rheumatoid	JJ	JJ	_	7	amod	_	_
6	synovial	synovial	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	up-regulates	up-regulate	VBZ	VBZ	_	0	root	_	_
9	VCAM-1	vcam-1	NN	NN	_	8	dobj	_	_
10	.	.	.	.	_	8	punct	_	_

1	CD44	cd44	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	ubiquitous	ubiquitous	JJ	JJ	_	5	amod	_	_
5	molecule	molecule	NN	NN	_	0	root	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	known	know	VBN	VBN	_	5	acl	_	_
8	as	as	IN	IN	_	10	case	_	_
9	hyaluronic	hyaluronic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	homing	homing	JJ	JJ	_	13	amod	_	_
13	receptor	receptor	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	20	advmod	_	_
2	,	,	,	,	_	20	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	cellular	cellular	JJ	JJ	_	5	amod	_	_
5	functions	function	NNS	NNS	_	20	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	role	role	NN	NN	_	5	conj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	inflammation	inflammation	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	for	for	IN	IN	_	16	case	_	_
13	example	example	NN	NN	_	16	dep	_	_
14	,	,	,	,	_	16	punct	_	_
15	rheumatoid	rheumatoid	JJ	JJ	_	16	amod	_	_
16	synovitis	synovitis	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	currently	currently	RB	RB	_	20	advmod	_	_
20	unknown	unknown	JJ	JJ	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	propose	propose	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	function	function	NN	NN	_	6	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	CD44	cd44	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	13	advcl	_	_
2	synovial	synovial	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	1	dobj	_	_
4	from	from	IN	IN	_	10	case	_	_
5	rheumatoid	rheumatoid	JJ	JJ	_	6	amod	_	_
6	arthritis	arthritis	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	RA	ra	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	patients	patient	NNS	NNS	_	3	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	21	mark	_	_
15	CD44	cd44	NN	NN	_	21	nsubj	_	_
16	cross-linking	cross-linking	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	binding	bind	VBG	VBG	_	16	conj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	hyaluronan	hyaluronan	NN	NN	_	18	nmod	_	_
21	augmented	augment	VBD	VBD	_	13	ccomp	_	_
22	VCAM-1	vcam-1	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	subsequently	subsequently	RB	RB	_	28	advmod	_	_
26	VCAM-1-mediated	vcam-1-mediated	JJ	JJ	_	28	amod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	adhesion	adhesion	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	Briefly	briefly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	1	1	LS	LS	_	12	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	rheumatoid	rheumatoid	JJ	JJ	_	10	amod	_	_
9	synovial	synovial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	12	nsubj	_	_
11	highly	highly	RB	RB	_	12	advmod	_	_
12	expressed	express	VBD	VBD	_	4	ccomp	_	_
13	CD44	cd44	NN	NN	_	12	dobj	_	_
14	;	;	:	:	_	12	punct	_	_
15	2	2	LS	LS	_	23	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	cross-linking	cross-linking	NN	NN	_	23	nsubj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	CD44	cd44	NN	NN	_	17	nmod	_	_
20	markedly	markedly	RB	RB	_	21	advmod	_	_
21	but	but	CC	CC	_	23	advmod	_	_
22	transiently	transiently	RB	RB	_	21	advmod	_	_
23	augmented	augment	VBD	VBD	_	12	conj	_	_
24	VCAM-1	vcam-1	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
28	mRNA	mrna	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	25	conj	_	_
30	much	much	RB	RB	_	31	advmod	_	_
31	more	more	JJR	JJR	_	23	advmod	_	_
32	than	than	IN	IN	_	33	dep	_	_
33	did	do	VBD	VBD	_	31	advcl	_	_
34	IL-1beta	il-1beta	NN	NN	_	33	nsubj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	TNF-alpha	tnf-alpha	NN	NN	_	34	conj	_	_
37	;	;	:	:	_	12	punct	_	_
38	3	3	LS	LS	_	47	dep	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	hyaluronan	hyaluronan	NN	NN	_	47	nsubj	_	_
41	,	,	,	,	_	47	punct	_	_
42	especially	especially	RB	RB	_	43	advmod	_	_
43	when	when	WRB	WRB	_	44	advmod	_	_
44	fragmented	fragmented	JJ	JJ	_	47	advcl	_	_
45	,	,	,	,	_	47	punct	_	_
46	also	also	RB	RB	_	47	advmod	_	_
47	up-regulated	up-regulate	VBD	VBD	_	12	conj	_	_
48	VCAM-1	vcam-1	NN	NN	_	47	dobj	_	_
49	;	;	:	:	_	12	punct	_	_
50	4	4	LS	LS	_	53	dep	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	CD44	cd44	NN	NN	_	53	nsubj	_	_
53	activated	activate	VBD	VBD	_	12	conj	_	_
54	the	the	DT	DT	_	57	det	_	_
55	transcription	transcription	NN	NN	_	57	compound	_	_
56	factor	factor	NN	NN	_	57	compound	_	_
57	AP-1	ap-1	NN	NN	_	53	dobj	_	_
58	;	;	:	:	_	12	punct	_	_
59	and	and	CC	CC	_	12	cc	_	_
60	5	5	LS	LS	_	75	dep	_	_
61	)	)	-RRB-	-RRB-	_	60	punct	_	_
62	the	the	DT	DT	_	65	det	_	_
63	integrin-dependent	integrin-dependent	JJ	JJ	_	65	amod	_	_
64	adhesive	adhesive	JJ	JJ	_	65	amod	_	_
65	function	function	NN	NN	_	75	nsubjpass	_	_
66	of	of	IN	IN	_	69	case	_	_
67	RA	ra	NN	NN	_	69	compound	_	_
68	synovial	synovial	JJ	JJ	_	69	amod	_	_
69	cells	cell	NNS	NNS	_	65	nmod	_	_
70	to	to	TO	TO	_	72	case	_	_
71	T	t	NN	NN	_	72	compound	_	_
72	cells	cell	NNS	NNS	_	65	nmod	_	_
73	was	be	VBD	VBD	_	75	auxpass	_	_
74	also	also	RB	RB	_	75	advmod	_	_
75	amplified	amplify	VBD	VBD	_	12	conj	_	_
76	by	by	IN	IN	_	78	case	_	_
77	CD44	cd44	NN	NN	_	78	compound	_	_
78	cross-linking	cross-linking	NN	NN	_	75	nmod	_	_
79	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	adhesion	adhesion	NN	NN	_	20	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	RA	ra	NN	NN	_	10	compound	_	_
9	synovial	synovial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	matrices	matrix	NNS	NNS	_	6	nmod	_	_
13	such	such	JJ	JJ	_	16	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	hyaluronic	hyaluronic	JJ	JJ	_	16	amod	_	_
16	acid	acid	NN	NN	_	12	nmod	_	_
17	through	through	IN	IN	_	18	case	_	_
18	CD44	cd44	NN	NN	_	6	nmod	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	up-regulate	up-regulate	VB	VB	_	3	ccomp	_	_
21	VCAM-1	vcam-1	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	VCAM-1-mediated	vcam-1-mediated	JJ	JJ	_	25	amod	_	_
25	adhesion	adhesion	NN	NN	_	22	conj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	which	which	WDT	WDT	_	34	nsubj	_	_
31	might	might	MD	MD	_	34	aux	_	_
32	in	in	IN	IN	_	33	case	_	_
33	turn	turn	NN	NN	_	34	nmod	_	_
34	cause	cause	VB	VB	_	20	ccomp	_	_
35	activation	activation	NN	NN	_	34	dobj	_	_
36	of	of	IN	IN	_	38	case	_	_
37	T	t	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	35	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	synovial	synovial	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	38	conj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	RA	ra	NN	NN	_	44	compound	_	_
44	synovitis	synovitis	NN	NN	_	38	nmod	_	_
45	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	propose	propose	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	such	such	JJ	JJ	_	6	amod	_	_
6	cross-talking	cross-talking	NN	NN	_	13	nsubjpass	_	_
7	among	among	IN	IN	_	10	case	_	_
8	distinct	distinct	JJ	JJ	_	10	amod	_	_
9	adhesion	adhesion	NN	NN	_	10	compound	_	_
10	molecules	molecule	NNS	NNS	_	6	nmod	_	_
11	may	may	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	involved	involve	VBN	VBN	_	3	ccomp	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	pathogenesis	pathogenesis	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	inflammation	inflammation	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	22	case	_	_
21	RA	ra	NN	NN	_	22	compound	_	_
22	synovitis	synovitis	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Oleic	oleic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	:	:	:	:	_	3	punct	_	_
7	A	a	DT	DT	_	11	det	_	_
8	direct	direct	JJ	JJ	_	11	amod	_	_
9	vascular	vascular	JJ	JJ	_	11	amod	_	_
10	antiatherogenic	antiatherogenic	JJ	JJ	_	11	amod	_	_
11	mechanism	mechanism	NN	NN	_	3	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	nutritional	nutritional	JJ	JJ	_	15	amod	_	_
15	component	component	NN	NN	_	11	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	mediterranean	mediterranean	JJ	JJ	_	19	amod	_	_
19	diet	diet	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	oleic	oleic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	implicated	implicate	VBN	VBN	_	17	advcl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	antiatherogenic	antiatherogenic	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	5	nmod	_	_
10	attributed	attribute	VBN	VBN	_	9	acl	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	Mediterranean	mediterranean	JJ	JJ	_	14	amod	_	_
14	diet	diet	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	investigated	investigate	VBD	VBD	_	0	root	_	_
18	whether	whether	IN	IN	_	23	mark	_	_
19	this	this	DT	DT	_	21	det	_	_
20	fatty	fatty	JJ	JJ	_	21	amod	_	_
21	acid	acid	NN	NN	_	23	nsubj	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	modulate	modulate	VB	VB	_	17	ccomp	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	activation	activation	NN	NN	_	23	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	ie	ie	FW	FW	_	31	advmod	_	_
28	,	,	,	,	_	31	punct	_	_
29	the	the	DT	DT	_	31	det	_	_
30	concerted	concerted	JJ	JJ	_	31	amod	_	_
31	expression	expression	NN	NN	_	25	appos	_	_
32	of	of	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	products	product	NNS	NNS	_	31	nmod	_	_
35	involved	involve	VBN	VBN	_	34	acl	_	_
36	in	in	IN	IN	_	38	case	_	_
37	leukocyte	leukocyte	NN	NN	_	38	compound	_	_
38	recruitment	recruitment	NN	NN	_	35	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	early	early	JJ	JJ	_	41	amod	_	_
41	atherogenesis	atherogenesis	NN	NN	_	38	conj	_	_
42	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	incubated	incubate	VBD	VBD	_	0	root	_	_
3	sodium	sodium	NN	NN	_	4	compound	_	_
4	oleate	oleate	NN	NN	_	2	dobj	_	_
5	with	with	IN	IN	_	10	case	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	umbilical	umbilical	JJ	JJ	_	10	amod	_	_
8	vein	vein	NN	NN	_	10	compound	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	for	for	IN	IN	_	15	case	_	_
12	0	0	CD	CD	_	14	compound	_	_
13	to	to	TO	TO	_	14	dep	_	_
14	72	72	CD	CD	_	15	nummod	_	_
15	hours	hour	NNS	NNS	_	2	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	followed	follow	VBN	VBN	_	2	advcl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	coincubation	coincubation	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	oleate	oleate	NN	NN	_	19	nmod	_	_
22	with	with	IN	IN	_	27	case	_	_
23	human	human	JJ	JJ	_	27	amod	_	_
24	recombinant	recombinant	JJ	JJ	_	27	amod	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	19	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	interleukin	interleukin	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	IL	il	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	-1alpha	-1alpha	NN	NN	_	27	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	IL-1beta	il-1beta	NN	NN	_	27	conj	_	_
36	,	,	,	,	_	27	punct	_	_
37	IL-4	il-4	NN	NN	_	27	conj	_	_
38	,	,	,	,	_	27	punct	_	_
39	Escherichia	escherichia	FW	FW	_	41	compound	_	_
40	coli	coli	FW	FW	_	41	dep	_	_
41	lipopolysaccharide	lipopolysaccharide	NN	NN	_	27	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	LPS	lps	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	27	punct	_	_
46	or	or	CC	CC	_	27	cc	_	_
47	phorbol	phorbol	NN	NN	_	49	compound	_	_
48	12-myristate	12-myristate	NN	NN	_	49	compound	_	_
49	13-acetate	13-acetate	NN	NN	_	27	conj	_	_
50	for	for	IN	IN	_	56	case	_	_
51	a	a	DT	DT	_	56	det	_	_
52	further	further	JJ	JJ	_	56	amod	_	_
53	6	6	CD	CD	_	55	compound	_	_
54	to	to	TO	TO	_	55	dep	_	_
55	24	24	CD	CD	_	56	nummod	_	_
56	hours	hour	NNS	NNS	_	19	nmod	_	_
57	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	endothelial	endothelial	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	20	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	vascular	vascular	JJ	JJ	_	8	amod	_	_
6	cell	cell	NN	NN	_	8	compound	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	VCAM-1	vcam-1	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	8	punct	_	_
13	E-selectin	e-selectin	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	8	punct	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	intercellular	intercellular	JJ	JJ	_	18	amod	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecule-1	molecule-1	NN	NN	_	8	conj	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	monitored	monitor	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	25	case	_	_
22	cell	cell	NN	NN	_	25	compound	_	_
23	surface	surface	NN	NN	_	25	compound	_	_
24	enzyme	enzyme	NN	NN	_	25	compound	_	_
25	immunoassays	immunoassay	NNS	NNS	_	20	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	flow	flow	NN	NN	_	28	compound	_	_
28	cytometry	cytometry	NN	NN	_	25	conj	_	_
29	,	,	,	,	_	20	punct	_	_
30	and	and	CC	CC	_	20	cc	_	_
31	steady-state	steady-state	JJ	JJ	_	32	amod	_	_
32	levels	level	NNS	NNS	_	37	nsubjpass	_	_
33	of	of	IN	IN	_	35	case	_	_
34	VCAM-1	vcam-1	NN	NN	_	35	compound	_	_
35	mRNA	mrna	NN	NN	_	32	nmod	_	_
36	were	be	VBD	VBD	_	37	auxpass	_	_
37	assessed	assess	VBN	VBN	_	20	conj	_	_
38	by	by	IN	IN	_	41	case	_	_
39	Northern	northern	NN	NN	_	41	compound	_	_
40	blot	blot	NN	NN	_	41	compound	_	_
41	analysis	analysis	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	20	punct	_	_

1	At	at	IN	IN	_	5	case	_	_
2	10	10	CD	CD	_	4	compound	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	100	100	CD	CD	_	5	nummod	_	_
5	micromol/L	micromol/l	NN	NN	_	12	nmod	_	_
6	for	for	IN	IN	_	9	case	_	_
7	&gt;	&gt;	JJR	JJR	_	8	advmod	_	_
8	24	24	CD	CD	_	9	nummod	_	_
9	hours	hour	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	oleate	oleate	NN	NN	_	12	nsubj	_	_
12	inhibited	inhibit	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	all	all	DT	DT	_	18	det	_	_
17	adhesion	adhesion	NN	NN	_	18	compound	_	_
18	molecules	molecule	NNS	NNS	_	14	nmod	_	_
19	tested	test	VBN	VBN	_	18	acl	_	_
20	.	.	.	.	_	12	punct	_	_

1	After	after	IN	IN	_	4	case	_	_
2	a	a	DT	DT	_	4	det	_	_
3	72-hour	72-hour	JJ	JJ	_	4	amod	_	_
4	incubation	incubation	NN	NN	_	22	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	oleate	oleate	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	a	a	DT	DT	_	11	det	_	_
9	further	further	JJ	JJ	_	11	amod	_	_
10	16-hour	16-hour	JJ	JJ	_	11	amod	_	_
11	incubation	incubation	NN	NN	_	4	conj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	oleate	oleate	NN	NN	_	11	nmod	_	_
14	plus	plus	CC	CC	_	13	cc	_	_
15	1	1	CD	CD	_	16	compound	_	_
16	microg/mL	microg/ml	NN	NN	_	17	amod	_	_
17	LPS	lps	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	22	punct	_	_
19	VCAM-1	vcam-1	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	reduced	reduce	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	26	case	_	_
24	&gt;	&gt;	JJR	JJR	_	25	advmod	_	_
25	40	40	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	22	nmod	_	_
27	compared	compare	VBN	VBN	_	29	case	_	_
28	with	with	IN	IN	_	29	case	_	_
29	control	control	NN	NN	_	22	advcl	_	_
30	.	.	.	.	_	22	punct	_	_

1	Adhesion	adhesion	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	monocytoid	monocytoid	JJ	JJ	_	5	amod	_	_
4	U937	u937	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	LPS-treated	lps-treated	JJ	JJ	_	9	amod	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	1	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	reduced	reduce	VBN	VBN	_	0	root	_	_
12	concomitantly	concomitantly	RB	RB	_	11	advmod	_	_
13	.	.	.	.	_	11	punct	_	_

1	Oleate	oleate	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	produced	produce	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	quantitatively	quantitatively	RB	RB	_	6	advmod	_	_
6	similar	similar	JJ	JJ	_	7	amod	_	_
7	reduction	reduction	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	VCAM-1	vcam-1	NN	NN	_	11	compound	_	_
10	mRNA	mrna	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	7	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	Northern	northern	NN	NN	_	15	compound	_	_
14	blot	blot	NN	NN	_	15	compound	_	_
15	analysis	analysis	NN	NN	_	3	nmod	_	_
16	and	and	CC	CC	_	3	cc	_	_
17	inhibited	inhibit	VBD	VBD	_	3	conj	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	factor-kappaB	factor-kappab	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	dobj	_	_
21	on	on	IN	IN	_	25	case	_	_
22	electrophoretic	electrophoretic	JJ	JJ	_	25	amod	_	_
23	mobility	mobility	NN	NN	_	25	compound	_	_
24	shift	shift	NN	NN	_	25	compound	_	_
25	assays	assay	NNS	NNS	_	17	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Incubation	incubation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	endothelial	endothelial	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	oleate	oleate	NN	NN	_	1	nmod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	72	72	CD	CD	_	9	nummod	_	_
9	hours	hour	NNS	NNS	_	1	nmod	_	_
10	decreased	decrease	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	relative	relative	JJ	JJ	_	13	amod	_	_
13	proportions	proportion	NNS	NNS	_	10	dobj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	saturated	saturated	JJ	JJ	_	21	amod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	palmitic	palmitic	JJ	JJ	_	15	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	stearic	stearic	JJ	JJ	_	17	conj	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	acids	acid	NNS	NNS	_	13	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	total	total	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	lipids	lipid	NNS	NNS	_	10	nmod	_	_
26	and	and	CC	CC	_	10	cc	_	_
27	increased	increase	VBD	VBD	_	10	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	proportions	proportion	NNS	NNS	_	27	dobj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	oleate	oleate	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	total	total	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lipids	lipid	NNS	NNS	_	29	nmod	_	_
36	without	without	IN	IN	_	38	mark	_	_
37	significantly	significantly	RB	RB	_	38	advmod	_	_
38	changing	change	VBG	VBG	_	27	advcl	_	_
39	the	the	DT	DT	_	41	det	_	_
40	relative	relative	JJ	JJ	_	41	amod	_	_
41	proportions	proportion	NNS	NNS	_	38	dobj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	polyunsaturated	polyunsaturated	JJ	JJ	_	45	amod	_	_
44	fatty	fatty	JJ	JJ	_	45	amod	_	_
45	acids	acid	NNS	NNS	_	41	nmod	_	_
46	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	less	less	JJR	JJR	_	3	dep	_	_
3	potent	potent	JJ	JJ	_	16	advcl	_	_
4	than	than	IN	IN	_	7	case	_	_
5	polyunsaturated	polyunsaturated	JJ	JJ	_	7	amod	_	_
6	fatty	fatty	JJ	JJ	_	7	amod	_	_
7	acids	acid	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	inhibiting	inhibit	VBG	VBG	_	3	advcl	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	,	,	,	,	_	16	punct	_	_
13	oleic	oleic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	16	nsubj	_	_
15	may	may	MD	MD	_	16	aux	_	_
16	contribute	contribute	VB	VB	_	0	root	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	prevention	prevention	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	atherogenesis	atherogenesis	NN	NN	_	19	nmod	_	_
22	through	through	IN	IN	_	24	case	_	_
23	selective	selective	JJ	JJ	_	24	amod	_	_
24	displacement	displacement	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	saturated	saturated	JJ	JJ	_	28	amod	_	_
27	fatty	fatty	JJ	JJ	_	28	amod	_	_
28	acids	acid	NNS	NNS	_	24	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	membrane	membrane	NN	NN	_	32	compound	_	_
32	phospholipids	phospholipid	NNS	NNS	_	24	nmod	_	_
33	and	and	CC	CC	_	19	cc	_	_
34	a	a	DT	DT	_	36	det	_	_
35	consequent	consequent	JJ	JJ	_	36	amod	_	_
36	modulation	modulation	NN	NN	_	19	conj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	gene	gene	NN	NN	_	39	compound	_	_
39	expression	expression	NN	NN	_	36	nmod	_	_
40	for	for	IN	IN	_	41	case	_	_
41	molecules	molecule	NNS	NNS	_	36	nmod	_	_
42	involved	involve	VBN	VBN	_	41	acl	_	_
43	in	in	IN	IN	_	45	case	_	_
44	monocyte	monocyte	JJ	JJ	_	45	amod	_	_
45	recruitment	recruitment	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	association	association	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Nmi	nmi	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	Stat5	stat5	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Stat1	stat1	NN	NN	_	6	conj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	IL-2-	il-2-	NN	NN	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	IFNgamma-mediated	ifngamma-mediated	JJ	JJ	_	10	conj	_	_
13	signaling	signaling	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	17	advcl	_	_
2	the	the	DT	DT	_	4	det	_	_
3	coiled-coil	coiled-coil	JJ	JJ	_	4	amod	_	_
4	region	region	NN	NN	_	1	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Stat5b	stat5b	NN	NN	_	4	nmod	_	_
7	as	as	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	bait	bait	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	yeast	yeast	NN	NN	_	14	compound	_	_
13	two-hybrid	two-hybrid	JJ	JJ	_	14	amod	_	_
14	screen	screen	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	identified	identify	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	association	association	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Nmi	nmi	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	24	det	_	_
24	protein	protein	NN	NN	_	21	appos	_	_
25	of	of	IN	IN	_	27	case	_	_
26	unknown	unknown	JJ	JJ	_	27	amod	_	_
27	function	function	NN	NN	_	24	nmod	_	_
28	previously	previously	RB	RB	_	29	advmod	_	_
29	reported	report	VBN	VBN	_	27	acl	_	_
30	as	as	IN	IN	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	N-Myc	n-myc	NN	NN	_	33	compound	_	_
33	interactor	interactor	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Nmi	nmi	NN	NN	_	6	nsubj	_	_
6	interacts	interact	VBZ	VBZ	_	3	ccomp	_	_
7	with	with	IN	IN	_	9	case	_	_
8	all	all	DT	DT	_	9	det	_	_
9	STATs	stats	NNS	NNS	_	6	nmod	_	_
10	except	except	IN	IN	_	11	case	_	_
11	Stat2	stat2	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	two	two	CD	CD	_	5	nummod	_	_
4	cytokine	cytokine	NN	NN	_	5	compound	_	_
5	systems	system	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	IL-2	il-2	NN	NN	_	5	appos	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IFNgamma	ifngamma	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	2	punct	_	_
11	and	and	CC	CC	_	2	cc	_	_
12	demonstrate	demonstrate	VBP	VBP	_	2	conj	_	_
13	that	that	IN	IN	_	15	mark	_	_
14	Nmi	nmi	NN	NN	_	15	nsubj	_	_
15	augments	augment	VBZ	VBZ	_	12	ccomp	_	_
16	STAT-mediated	stat-mediated	JJ	JJ	_	17	amod	_	_
17	transcription	transcription	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	response	response	NN	NN	_	22	dep	_	_
20	to	to	TO	TO	_	22	case	_	_
21	these	these	DT	DT	_	22	det	_	_
22	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Interestingly	interestingly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Nmi	nmi	NN	NN	_	4	nsubj	_	_
4	lacks	lack	VBZ	VBZ	_	0	root	_	_
5	an	a	DT	DT	_	9	det	_	_
6	intrinsic	intrinsic	JJ	JJ	_	9	amod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	activation	activation	NN	NN	_	9	compound	_	_
9	domain	domain	NN	NN	_	4	dobj	_	_
10	;	;	:	:	_	4	punct	_	_
11	instead	instead	RB	RB	_	14	advmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	Nmi	nmi	NN	NN	_	14	nsubj	_	_
14	enhances	enhance	VBZ	VBZ	_	4	parataxis	_	_
15	the	the	DT	DT	_	16	det	_	_
16	association	association	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	CBP/p300	cbp/p300	NN	NN	_	20	compound	_	_
19	coactivator	coactivator	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	16	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	Stat1	stat1	NN	NN	_	16	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Stat5	stat5	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	14	punct	_	_
26	and	and	CC	CC	_	14	cc	_	_
27	together	together	RB	RB	_	29	advmod	_	_
28	with	with	IN	IN	_	29	case	_	_
29	CBP/p300	cbp/p300	NN	NN	_	31	nmod	_	_
30	can	can	MD	MD	_	31	aux	_	_
31	augment	augment	VB	VB	_	14	conj	_	_
32	IL-2-	il-2-	NN	NN	_	35	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	IFNgamma-dependent	ifngamma-dependent	JJ	JJ	_	32	conj	_	_
35	transcription	transcription	NN	NN	_	31	dobj	_	_
36	.	.	.	.	_	4	punct	_	_

1	Therefore	therefore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	7	nsubj	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	only	only	RB	RB	_	7	cc:preconj	_	_
7	reveal	reveal	VBP	VBP	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	Nmi	nmi	NN	NN	_	11	nsubj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	potentiate	potentiate	VB	VB	_	7	ccomp	_	_
12	STAT-dependent	stat-dependent	JJ	JJ	_	13	amod	_	_
13	transcription	transcription	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	7	punct	_	_
15	but	but	CC	CC	_	7	cc	_	_
16	also	also	RB	RB	_	17	advmod	_	_
17	suggest	suggest	VBP	VBP	_	7	conj	_	_
18	that	that	IN	IN	_	21	mark	_	_
19	it	it	PRP	PRP	_	21	nsubj	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	augment	augment	VB	VB	_	17	ccomp	_	_
22	coactivator	coactivator	NN	NN	_	24	compound	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	recruitment	recruitment	NN	NN	_	21	dobj	_	_
25	to	to	TO	TO	_	29	case	_	_
26	at	at	IN	IN	_	27	case	_	_
27	least	least	JJS	JJS	_	29	advmod	_	_
28	some	some	DT	DT	_	29	det	_	_
29	members	member	NNS	NNS	_	21	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	group	group	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	36	case	_	_
34	sequence-specific	sequence-specific	JJ	JJ	_	36	amod	_	_
35	transcription	transcription	NN	NN	_	36	compound	_	_
36	factors	factor	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	7	punct	_	_

1	GA-binding	ga-binding	JJ	JJ	_	3	amod	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	12	case	_	_
6	concert	concert	NN	NN	_	12	dep	_	_
7	with	with	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	coactivator	coactivator	NN	NN	_	12	compound	_	_
10	CREB	creb	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	protein/p300	protein/p300	NN	NN	_	3	nmod	_	_
13	,	,	,	,	_	3	punct	_	_
14	control	control	VBP	VBP	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	induction	induction	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	interleukin	interleukin	NN	NN	_	21	compound	_	_
20	16	16	CD	CD	_	21	nummod	_	_
21	promoter	promoter	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	Interleukin	interleukin	NN	NN	_	9	nsubj	_	_
2	16	16	CD	CD	_	1	nummod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	IL-16	il-16	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	chemotactic	chemotactic	JJ	JJ	_	9	amod	_	_
9	cytokine	cytokine	NN	NN	_	0	root	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	binds	bind	VBZ	VBZ	_	9	acl:relcl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CD4	cd4	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	affects	affect	VBZ	VBZ	_	11	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	replication	replication	NN	NN	_	19	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	HIV	hiv	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	as	as	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	large	large	JJ	JJ	_	9	amod	_	_
7	67-kDa	67-kda	JJ	JJ	_	9	amod	_	_
8	precursor	precursor	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	pro-IL-16	pro-il-16	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	macrophages	macrophage	NNS	NNS	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	mast	mast	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	as	as	RB	RB	_	14	cc	_	_
23	well	well	RB	RB	_	22	mwe	_	_
24	as	as	IN	IN	_	22	mwe	_	_
25	in	in	IN	IN	_	28	case	_	_
26	airway	airway	NN	NN	_	28	compound	_	_
27	epithelial	epithelial	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	14	conj	_	_
29	from	from	IN	IN	_	30	case	_	_
30	asthmatics	asthmatic	NNS	NNS	_	28	nmod	_	_
31	after	after	IN	IN	_	32	case	_	_
32	challenge	challenge	NN	NN	_	30	nmod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	allergen	allergen	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pro-IL-16	pro-il-16	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	subsequently	subsequently	RB	RB	_	5	advmod	_	_
5	processed	process	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	mature	mature	JJ	JJ	_	9	amod	_	_
9	cytokine	cytokine	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	13	13	CD	CD	_	12	nummod	_	_
12	kDa	kda	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	study	study	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-16	il-16	NN	NN	_	4	nmod	_	_
7	at	at	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	level	level	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	cloned	clone	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	chromosomal	chromosomal	JJ	JJ	_	18	amod	_	_
17	IL-16	il-16	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	13	dobj	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	analyzed	analyze	VBD	VBD	_	13	conj	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	promoter	promoter	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	IL-16	il-16	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	5	nsubj	_	_
5	consists	consist	VBZ	VBZ	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	seven	seven	CD	CD	_	8	nummod	_	_
8	exons	exon	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	six	six	CD	CD	_	11	nummod	_	_
11	introns	intron	NNS	NNS	_	8	conj	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	5'	5'	JJ	JJ	_	3	amod	_	_
3	sequences	sequence	NNS	NNS	_	15	nsubj	_	_
4	up	up	RP	RP	_	6	dep	_	_
5	to	to	TO	TO	_	6	case	_	_
6	nucleotide	nucleotide	NN	NN	_	3	nmod	_	_
7	-120	-120	CD	CD	_	6	nummod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	human	human	JJ	JJ	_	14	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	murine	murine	JJ	JJ	_	10	conj	_	_
13	IL-16	il-16	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	6	nmod	_	_
15	share	share	VBP	VBP	_	0	root	_	_
16	&gt;	&gt;	JJR	JJR	_	17	advmod	_	_
17	84	84	CD	CD	_	18	nummod	_	_
18	%	%	NN	NN	_	15	dobj	_	_
19	sequence	sequence	NN	NN	_	20	compound	_	_
20	homology	homology	NN	NN	_	18	dep	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	harbor	harbor	VBP	VBP	_	15	conj	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	elements	element	NNS	NNS	_	22	dobj	_	_
25	for	for	IN	IN	_	29	case	_	_
26	constitutive	constitutive	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	inducible	inducible	JJ	JJ	_	26	conj	_	_
29	transcription	transcription	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	both	both	DT	DT	_	3	det	_	_
3	promoters	promoter	NNS	NNS	_	4	nsubj	_	_
4	lack	lack	VBP	VBP	_	10	advcl	_	_
5	any	any	DT	DT	_	7	det	_	_
6	TATA	tata	NN	NN	_	7	compound	_	_
7	box	box	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	10	punct	_	_
9	they	they	PRP	PRP	_	10	nsubj	_	_
10	contain	contain	VBP	VBP	_	0	root	_	_
11	two	two	CD	CD	_	14	nummod	_	_
12	CAAT	caat	NN	NN	_	14	compound	_	_
13	box-like	box-like	JJ	JJ	_	14	amod	_	_
14	motifs	motif	NNS	NNS	_	10	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	three	three	CD	CD	_	18	nummod	_	_
17	binding	bind	VBG	VBG	_	18	amod	_	_
18	sites	site	NNS	NNS	_	14	conj	_	_
19	of	of	IN	IN	_	26	case	_	_
20	GA-binding	ga-binding	JJ	JJ	_	26	amod	_	_
21	protein	protein	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	GABP	gabp	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	14	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Two	two	CD	CD	_	6	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	motifs	motif	NNS	NNS	_	1	nmod	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	part	part	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	15	case	_	_
8	a	a	DT	DT	_	15	det	_	_
9	highly	highly	RB	RB	_	10	advmod	_	_
10	conserved	conserve	VBN	VBN	_	15	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	inducible	inducible	JJ	JJ	_	10	conj	_	_
13	dyad	dyad	NN	NN	_	15	compound	_	_
14	symmetry	symmetry	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	6	nmod	_	_
16	shown	show	VBN	VBN	_	15	acl	_	_
17	previously	previously	RB	RB	_	16	advmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	control	control	VB	VB	_	16	xcomp	_	_
20	a	a	DT	DT	_	23	det	_	_
21	remote	remote	JJ	JJ	_	23	amod	_	_
22	IL-2	il-2	NN	NN	_	23	compound	_	_
23	enhancer	enhancer	NN	NN	_	19	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	27	det	_	_
26	CD18	cd18	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	23	conj	_	_
28	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	8	case	_	_
2	concert	concert	NN	NN	_	8	dep	_	_
3	with	with	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	coactivator	coactivator	NN	NN	_	8	compound	_	_
6	CREB	creb	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	protein/p300	protein/p300	NN	NN	_	26	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	interacts	interact	VBZ	VBZ	_	8	acl:relcl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	GABPalpha	gabpalpha	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	26	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	binding	binding	NN	NN	_	26	nsubj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	GABPalpha	gabpalpha	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-beta	-beta	NN	NN	_	18	conj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	dyad	dyad	NN	NN	_	25	compound	_	_
24	symmetry	symmetry	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	16	nmod	_	_
26	controls	control	VBZ	VBZ	_	0	root	_	_
27	the	the	DT	DT	_	28	det	_	_
28	induction	induction	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	IL-16	il-16	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	28	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	26	punct	_	_

1	Supplementing	supplement	VBG	VBG	_	12	advcl	_	_
2	the	the	DT	DT	_	3	det	_	_
3	data	datum	NNS	NNS	_	1	dobj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	processing	processing	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	pro-IL-16	pro-il-16	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	our	we	PRP$	PRP$	_	11	nmod:poss	_	_
11	results	result	NNS	NNS	_	12	nsubj	_	_
12	indicate	indicate	VBP	VBP	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	complexity	complexity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IL-16	il-16	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	22	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	22	auxpass	_	_
21	tightly	tightly	RB	RB	_	22	advmod	_	_
22	controlled	control	VBN	VBN	_	17	acl:relcl	_	_
23	at	at	IN	IN	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	posttranslational	posttranslational	JJ	JJ	_	25	conj	_	_
28	levels	level	NNS	NNS	_	22	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	22	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	resistance	resistance	NN	NN	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	squirrel	squirrel	NN	NN	_	6	compound	_	_
6	monkey	monkey	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	associated	associate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	overexpression	overexpression	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	immunophilin	immunophilin	NN	NN	_	14	compound	_	_
14	FKBP51	fkbp51	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Squirrel	squirrel	NN	NN	_	2	compound	_	_
2	monkeys	monkey	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	neotropical	neotropical	JJ	JJ	_	5	amod	_	_
5	primates	primate	NNS	NNS	_	0	root	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	have	have	VBP	VBP	_	5	acl:relcl	_	_
8	high	high	JJ	JJ	_	10	amod	_	_
9	circulating	circulate	VBG	VBG	_	10	amod	_	_
10	cortisol	cortisol	NN	NN	_	7	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	compensate	compensate	VB	VB	_	10	acl	_	_
13	for	for	IN	IN	_	14	case	_	_
14	expression	expression	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	glucocorticoid	glucocorticoid	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	GRs	gr	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	with	with	IN	IN	_	23	case	_	_
22	reduced	reduce	VBN	VBN	_	23	amod	_	_
23	affinity	affinity	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	low	low	JJ	JJ	_	4	amod	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	affinity	affinity	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	squirrel	squirrel	NN	NN	_	8	compound	_	_
7	monkey	monkey	NN	NN	_	8	compound	_	_
8	GR	gr	NN	NN	_	4	nmod	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	result	result	VB	VB	_	0	root	_	_
12	from	from	IN	IN	_	13	case	_	_
13	substitutions	substitution	NNS	NNS	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	receptor	receptor	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	because	because	IN	IN	_	25	mark	_	_
19	squirrel	squirrel	NN	NN	_	21	compound	_	_
20	monkey	monkey	NN	NN	_	21	compound	_	_
21	GR	gr	NN	NN	_	25	nsubj	_	_
22	expressed	express	VBN	VBN	_	21	acl	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	22	advmod	_	_
25	exhibits	exhibit	VBZ	VBZ	_	11	advcl	_	_
26	high	high	JJ	JJ	_	27	amod	_	_
27	affinity	affinity	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	11	punct	_	_

1	Rather	rather	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	squirrel	squirrel	NN	NN	_	4	compound	_	_
4	monkeys	monkey	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	soluble	soluble	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	5	dobj	_	_
9	that	that	WDT	WDT	_	28	nsubj	_	_
10	,	,	,	,	_	28	punct	_	_
11	in	in	IN	IN	_	13	case	_	_
12	mixing	mixing	JJ	JJ	_	13	amod	_	_
13	studies	study	NNS	NNS	_	28	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cytosol	cytosol	NN	NN	_	13	nmod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	squirrel	squirrel	NN	NN	_	19	compound	_	_
18	monkey	monkey	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	SML	sml	NNS	NNS	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	mouse	mouse	NN	NN	_	26	compound	_	_
25	L929	l929	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	19	conj	_	_
27	,	,	,	,	_	28	punct	_	_
28	reduced	reduce	VBD	VBD	_	8	acl:relcl	_	_
29	GR	gr	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	affinity	affinity	NN	NN	_	28	dobj	_	_
32	by	by	IN	IN	_	33	case	_	_
33	11-fold	11-fold	JJ	JJ	_	28	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	an	a	DT	DT	_	3	det	_	_
3	effort	effort	NN	NN	_	27	nmod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	identify	identify	VB	VB	_	3	acl	_	_
6	this	this	DT	DT	_	7	det	_	_
7	factor	factor	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	27	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	levels	level	NNS	NNS	_	27	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	components	component	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	GR	gr	NN	NN	_	17	compound	_	_
17	heterocomplex	heterocomplex	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	SML	sml	NNS	NNS	_	11	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	HL	hl	NNS	NNS	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	compared	compare	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunophilin	immunophilin	NN	NN	_	3	compound	_	_
3	FKBP51	fkbp51	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	13-fold	13-fold	RB	RB	_	6	advmod	_	_
6	higher	higher	JJR	JJR	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	SML	sml	NNS	NNS	_	6	nmod	_	_
9	than	than	IN	IN	_	12	case	_	_
10	in	in	IN	IN	_	12	case	_	_
11	HL	hl	NNS	NNS	_	12	compound	_	_
12	cytosol	cytosol	NN	NN	_	6	nmod	_	_
13	;	;	:	:	_	6	punct	_	_
14	FKBP52	fkbp52	NN	NN	_	19	nsubj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	SML	sml	NNS	NNS	_	14	nmod	_	_
17	was	be	VBD	VBD	_	19	cop	_	_
18	42	42	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	6	parataxis	_	_
20	of	of	IN	IN	_	21	case	_	_
21	that	that	DT	DT	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	HL	hl	NNS	NNS	_	24	compound	_	_
24	cytosol	cytosol	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	16	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	changes	change	NNS	NNS	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	immunophilins	immunophilin	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	causing	cause	VBG	VBG	_	2	dep	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	resistance	resistance	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	neotropical	neotropical	JJ	JJ	_	13	amod	_	_
13	primates	primate	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	2	punct	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	supported	support	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	following	following	NN	NN	_	16	nmod	_	_
20	:	:	:	:	_	19	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	changes	change	NNS	NNS	_	28	nsubjpass	_	_
23	in	in	IN	IN	_	24	case	_	_
24	FKBP51	fkbp51	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	FKBP52	fkbp52	NN	NN	_	24	conj	_	_
27	were	be	VBD	VBD	_	28	auxpass	_	_
28	observed	observe	VBN	VBN	_	19	dep	_	_
29	in	in	IN	IN	_	30	case	_	_
30	cells	cell	NNS	NNS	_	28	nmod	_	_
31	from	from	IN	IN	_	34	case	_	_
32	other	other	JJ	JJ	_	34	amod	_	_
33	neotropical	neotropical	JJ	JJ	_	34	amod	_	_
34	primates	primate	NNS	NNS	_	30	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	glucocorticoid	glucocorticoid	NN	NN	_	37	compound	_	_
37	resistance	resistance	NN	NN	_	34	nmod	_	_
38	;	;	:	:	_	28	punct	_	_
39	the	the	DT	DT	_	41	det	_	_
40	elevated	elevated	JJ	JJ	_	41	amod	_	_
41	level	level	NN	NN	_	45	nsubjpass	_	_
42	of	of	IN	IN	_	43	case	_	_
43	FKBP51	fkbp51	NN	NN	_	41	nmod	_	_
44	was	be	VBD	VBD	_	45	auxpass	_	_
45	reflected	reflect	VBN	VBN	_	28	conj	_	_
46	in	in	IN	IN	_	48	case	_	_
47	an	a	DT	DT	_	48	det	_	_
48	abundance	abundance	NN	NN	_	45	nmod	_	_
49	of	of	IN	IN	_	50	case	_	_
50	FKBP51	fkbp51	NN	NN	_	48	nmod	_	_
51	in	in	IN	IN	_	56	case	_	_
52	heat	heat	NN	NN	_	56	compound	_	_
53	shock	shock	NN	NN	_	56	compound	_	_
54	protein	protein	NN	NN	_	56	compound	_	_
55	90	90	CD	CD	_	56	nummod	_	_
56	complexes	complex	NNS	NNS	_	48	nmod	_	_
57	in	in	IN	IN	_	58	case	_	_
58	SML	sml	NNS	NNS	_	56	nmod	_	_
59	;	;	:	:	_	28	punct	_	_
60	when	when	WRB	WRB	_	68	advmod	_	_
61	cytosols	cytosol	NNS	NNS	_	68	nsubjpass	_	_
62	of	of	IN	IN	_	63	case	_	_
63	SML	sml	NNS	NNS	_	61	nmod	_	_
64	and	and	CC	CC	_	61	cc	_	_
65	L929	l929	NN	NN	_	66	compound	_	_
66	cells	cell	NNS	NNS	_	61	conj	_	_
67	were	be	VBD	VBD	_	68	auxpass	_	_
68	mixed	mix	VBN	VBN	_	76	advcl	_	_
69	,	,	,	,	_	76	punct	_	_
70	the	the	DT	DT	_	71	det	_	_
71	decrease	decrease	NN	NN	_	76	nsubjpass	_	_
72	in	in	IN	IN	_	74	case	_	_
73	GR	gr	NN	NN	_	74	compound	_	_
74	binding	binding	NN	NN	_	71	nmod	_	_
75	was	be	VBD	VBD	_	76	auxpass	_	_
76	associated	associate	VBN	VBN	_	28	conj	_	_
77	with	with	IN	IN	_	78	case	_	_
78	incorporation	incorporation	NN	NN	_	76	nmod	_	_
79	of	of	IN	IN	_	80	case	_	_
80	FKBP51	fkbp51	NN	NN	_	78	nmod	_	_
81	into	into	IN	IN	_	83	case	_	_
82	GR	gr	NN	NN	_	83	compound	_	_
83	heterocomplexes	heterocomplex	NNS	NNS	_	78	nmod	_	_
84	;	;	:	:	_	28	punct	_	_
85	the	the	DT	DT	_	86	det	_	_
86	effect	effect	NN	NN	_	94	nsubjpass	_	_
87	of	of	IN	IN	_	89	case	_	_
88	SML	sml	NNS	NNS	_	89	compound	_	_
89	cytosol	cytosol	NN	NN	_	86	nmod	_	_
90	on	on	IN	IN	_	92	case	_	_
91	GR	gr	NN	NN	_	92	compound	_	_
92	binding	binding	NN	NN	_	86	nmod	_	_
93	was	be	VBD	VBD	_	94	auxpass	_	_
94	reproduced	reproduce	VBN	VBN	_	28	conj	_	_
95	with	with	IN	IN	_	96	case	_	_
96	cytosol	cytosol	NN	NN	_	94	nmod	_	_
97	from	from	IN	IN	_	99	case	_	_
98	COS	cos	NN	NN	_	99	compound	_	_
99	cells	cell	NNS	NNS	_	96	nmod	_	_
100	expressing	express	VBG	VBG	_	99	acl	_	_
101	squirrel	squirrel	NN	NN	_	103	compound	_	_
102	monkey	monkey	NN	NN	_	103	compound	_	_
103	FKBP51	fkbp51	NN	NN	_	100	dobj	_	_
104	;	;	:	:	_	28	punct	_	_
105	and	and	CC	CC	_	28	cc	_	_
106	both	both	CC	CC	_	108	cc:preconj	_	_
107	the	the	DT	DT	_	108	det	_	_
108	effect	effect	NN	NN	_	124	nsubjpass	_	_
109	of	of	IN	IN	_	111	case	_	_
110	SML	sml	NNS	NNS	_	111	compound	_	_
111	cytosol	cytosol	NN	NN	_	108	nmod	_	_
112	on	on	IN	IN	_	114	case	_	_
113	GR	gr	NN	NN	_	114	compound	_	_
114	binding	binding	NN	NN	_	108	nmod	_	_
115	and	and	CC	CC	_	108	cc	_	_
116	the	the	DT	DT	_	117	det	_	_
117	incorporation	incorporation	NN	NN	_	108	conj	_	_
118	of	of	IN	IN	_	119	case	_	_
119	FKBP51	fkbp51	NN	NN	_	117	nmod	_	_
120	into	into	IN	IN	_	122	case	_	_
121	GR	gr	NN	NN	_	122	compound	_	_
122	heterocomplexes	heterocomplex	NNS	NNS	_	117	nmod	_	_
123	were	be	VBD	VBD	_	124	auxpass	_	_
124	blocked	block	VBN	VBN	_	28	conj	_	_
125	by	by	IN	IN	_	126	case	_	_
126	FK506	fk506	NN	NN	_	124	nmod	_	_
127	.	.	.	.	_	16	punct	_	_

1	Regulation	regulation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	GR	gr	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	FKBP51	fkbp51	NN	NN	_	1	nmod	_	_
7	represents	represent	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	previously	previously	RB	RB	_	10	advmod	_	_
10	unrecognized	unrecognized	JJ	JJ	_	11	amod	_	_
11	mechanism	mechanism	NN	NN	_	7	dobj	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	regulating	regulate	VBG	VBG	_	11	acl	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	sensitivity	sensitivity	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	7	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	nmod:npmod	_	_
3	intermediate-dependent	intermediate-dependent	JJ	JJ	_	5	amod	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	8	nsubj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	interleukin-1beta	interleukin-1beta	NN	NN	_	5	nmod	_	_
8	requires	require	VBZ	VBZ	_	0	root	_	_
9	5-lipoxygenase	5-lipoxygenase	NN	NN	_	13	compound	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	NADPH	nadph	NN	NN	_	9	conj	_	_
12	oxidase	oxidase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	dobj	_	_
14	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	reactive	reactive	JJ	JJ	_	10	amod	_	_
9	oxygen	oxygen	NN	NN	_	10	compound	_	_
10	intermediates	intermediate	NNS	NNS	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	ROIs	roi	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	16	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	6	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	proinflammatory	proinflammatory	JJ	JJ	_	19	amod	_	_
19	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
20	was	be	VBD	VBD	_	22	cop	_	_
21	cell	cell	NN	NN	_	22	nmod:npmod	_	_
22	specific	specific	JJ	JJ	_	3	ccomp	_	_
23	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	sources	source	NNS	NNS	_	11	nsubj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	ROIs	roi	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	various	various	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	types	type	NNS	NNS	_	4	nmod	_	_
11	are	be	VBP	VBP	_	0	root	_	_
12	yet	yet	RB	RB	_	11	advmod	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	determined	determine	VBN	VBN	_	11	xcomp	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	might	might	MD	MD	_	18	aux	_	_
18	include	include	VB	VB	_	11	conj	_	_
19	5-lipoxygenase	5-lipoxygenase	NN	NN	_	18	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	5-LOX	5-lox	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	NADPH	nadph	NN	NN	_	25	compound	_	_
25	oxidase	oxidase	NN	NN	_	19	conj	_	_
26	.	.	.	.	_	11	punct	_	_

1	5-LOX	5-lox	NN	NN	_	10	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	5-LOX	5-lox	NN	NN	_	5	compound	_	_
4	activating	activating	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	1	conj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	FLAP	flap	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	coexpressed	coexpress	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	but	but	CC	CC	_	15	cc	_	_
15	not	not	RB	RB	_	13	cc	_	_
16	in	in	IN	IN	_	20	case	_	_
17	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	epithelial	epithelial	JJ	JJ	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	13	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	Stimulation	stimulation	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	interleukin-1beta	interleukin-1beta	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IL-1beta	il-1beta	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	led	lead	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	13	case	_	_
12	ROI	roi	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	which	which	WDT	WDT	_	22	nsubjpass	_	_
19	could	could	MD	MD	_	22	aux	_	_
20	both	both	DT	DT	_	22	dobj	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	blocked	block	VBN	VBN	_	13	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	antioxidants	antioxidant	NNS	NNS	_	22	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	FLAP	flap	NN	NN	_	27	compound	_	_
27	inhibitors	inhibitor	NNS	NNS	_	24	conj	_	_
28	,	,	,	,	_	10	punct	_	_
29	confirming	confirm	VBG	VBG	_	10	xcomp	_	_
30	that	that	IN	IN	_	34	mark	_	_
31	5-LOX	5-lox	NN	NN	_	34	nsubj	_	_
32	was	be	VBD	VBD	_	34	cop	_	_
33	the	the	DT	DT	_	34	det	_	_
34	source	source	NN	NN	_	29	ccomp	_	_
35	of	of	IN	IN	_	36	case	_	_
36	ROIs	roi	NNS	NNS	_	34	nmod	_	_
37	and	and	CC	CC	_	34	cc	_	_
38	was	be	VBD	VBD	_	39	auxpass	_	_
39	required	require	VBN	VBN	_	34	conj	_	_
40	for	for	IN	IN	_	42	case	_	_
41	NF-kappaB	nf-kappab	NN	NN	_	42	compound	_	_
42	activation	activation	NN	NN	_	39	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	these	these	DT	DT	_	45	det	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	10	punct	_	_

1	IL-1beta	il-1beta	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	epithelial	epithelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	generate	generate	VB	VB	_	0	root	_	_
9	any	any	DT	DT	_	10	det	_	_
10	ROIs	roi	NNS	NNS	_	8	dobj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	16	nsubjpass	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	influenced	influence	VBN	VBN	_	8	conj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	5-LOX	5-lox	NN	NN	_	19	compound	_	_
19	inhibitors	inhibitor	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	reintroduction	reintroduction	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	functional	functional	JJ	JJ	_	8	amod	_	_
7	5-LOX	5-lox	NN	NN	_	8	compound	_	_
8	system	system	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	allowed	allow	VBD	VBD	_	0	root	_	_
13	ROI	roi	NN	NN	_	14	compound	_	_
14	production	production	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	5-LOX-dependent	5-lox-dependent	JJ	JJ	_	18	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	14	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	monocytic	monocytic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	IL-1beta	il-1beta	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	7	nsubj	_	_
7	led	lead	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ROIs	roi	NNS	NNS	_	10	nmod	_	_
13	which	which	WDT	WDT	_	15	nsubj	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	independent	independent	JJ	JJ	_	10	acl:relcl	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	5-LOX	5-lox	NN	NN	_	19	compound	_	_
19	enzyme	enzyme	NN	NN	_	15	nmod	_	_
20	but	but	CC	CC	_	15	cc	_	_
21	requires	require	VBZ	VBZ	_	15	conj	_	_
22	the	the	DT	DT	_	25	det	_	_
23	NADPH	nadph	NN	NN	_	25	compound	_	_
24	oxidase	oxidase	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pathway	pathway	NN	NN	_	3	nsubj	_	_
3	involves	involve	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	Rac1	rac1	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Cdc42	cdc42	NN	NN	_	5	conj	_	_
8	GTPases	gtpases	NN	NN	_	3	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	enzymes	enzyme	NNS	NNS	_	8	appos	_	_
12	which	which	WDT	WDT	_	15	nsubjpass	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	required	require	VBN	VBN	_	11	acl:relcl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	20	case	_	_
20	IL-1beta	il-1beta	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	epithelial	epithelial	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	three	three	CD	CD	_	7	nummod	_	_
5	different	different	JJ	JJ	_	7	amod	_	_
6	cell-specific	cell-specific	JJ	JJ	_	7	amod	_	_
7	pathways	pathway	NNS	NNS	_	8	nsubj	_	_
8	lead	lead	VBP	VBP	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	IL-1beta	il-1beta	NN	NN	_	11	nmod	_	_
14	:	:	:	:	_	8	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	pathway	pathway	NN	NN	_	8	dobj	_	_
17	dependent	dependent	JJ	JJ	_	16	amod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	ROI	roi	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	5-LOX	5-lox	NN	NN	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	,	,	,	,	_	16	punct	_	_
27	an	a	DT	DT	_	31	det	_	_
28	ROI-	roi-	NN	NN	_	31	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	5-LOX-independent	5-lox-independent	JJ	JJ	_	28	conj	_	_
31	pathway	pathway	NN	NN	_	16	conj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	epithelial	epithelial	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	16	punct	_	_
36	and	and	CC	CC	_	16	cc	_	_
37	a	a	DT	DT	_	38	det	_	_
38	pathway	pathway	NN	NN	_	16	conj	_	_
39	requiring	require	VBG	VBG	_	38	acl	_	_
40	ROI	roi	NN	NN	_	41	compound	_	_
41	production	production	NN	NN	_	39	dobj	_	_
42	by	by	IN	IN	_	44	case	_	_
43	NADPH	nadph	NN	NN	_	44	compound	_	_
44	oxidase	oxidase	NN	NN	_	41	nmod	_	_
45	in	in	IN	IN	_	47	case	_	_
46	monocytic	monocytic	JJ	JJ	_	47	amod	_	_
47	cells	cell	NNS	NNS	_	41	nmod	_	_
48	.	.	.	.	_	8	punct	_	_

1	Activation-dependent	activation-dependent	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	Fas	fas	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	requires	require	VBZ	VBZ	_	0	root	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
11	p50-p65	p50-p65	NN	NN	_	12	compound	_	_
12	recruitment	recruitment	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	9	punct	_	_

1	Fas	fas	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CD95	cd95	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	Fas	fas	NN	NN	_	7	compound	_	_
7	ligand	ligand	NN	NN	_	1	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	CD95L	cd95l	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	are	be	VBP	VBP	_	15	cop	_	_
12	an	a	DT	DT	_	15	det	_	_
13	interacting	interact	VBG	VBG	_	15	amod	_	_
14	receptor-ligand	receptor-ligand	JJ	JJ	_	15	amod	_	_
15	pair	pair	NN	NN	_	0	root	_	_
16	required	require	VBN	VBN	_	15	acl	_	_
17	for	for	IN	IN	_	19	case	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	homeostasis	homeostasis	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Lymphocyte	lymphocyte	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	results	result	VBZ	VBZ	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	upregulation	upregulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Fas	fas	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	the	the	DT	DT	_	12	det	_	_
12	acquisition	acquisition	NN	NN	_	6	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	sensitivity	sensitivity	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	FasL-mediated	fasl-mediated	JJ	JJ	_	17	amod	_	_
17	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	Fas	fas	NN	NN	_	3	compound	_	_
3	upregulation	upregulation	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	central	central	JJ	JJ	_	15	advcl	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	preservation	preservation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	immunologic	immunologic	JJ	JJ	_	11	amod	_	_
11	tolerance	tolerance	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	little	little	JJ	JJ	_	15	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	known	know	VBN	VBN	_	0	root	_	_
16	about	about	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	molecular	molecular	JJ	JJ	_	19	amod	_	_
19	machinery	machinery	NN	NN	_	15	nmod	_	_
20	underlying	underlie	VBG	VBG	_	19	acl	_	_
21	this	this	DT	DT	_	22	det	_	_
22	process	process	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	events	event	NNS	NNS	_	2	dobj	_	_
5	involved	involve	VBN	VBN	_	4	acl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	activation-induced	activation-induced	JJ	JJ	_	9	amod	_	_
8	Fas	fas	NN	NN	_	9	compound	_	_
9	upregulation	upregulation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	13	punct	_	_
11	we	we	PRP	PRP	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	accumulation	accumulation	NN	NN	_	13	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	fas	fas	NN	NN	_	19	compound	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	15	conj	_	_
24	in	in	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	Jurkat	jurkat	NN	NN	_	28	compound	_	_
27	T-cell	t-cell	NN	NN	_	28	compound	_	_
28	line	line	NN	NN	_	15	nmod	_	_
29	treated	treat	VBN	VBN	_	28	acl	_	_
30	with	with	IN	IN	_	33	case	_	_
31	phorbol	phorbol	NN	NN	_	33	compound	_	_
32	myristate	myristate	NN	NN	_	33	compound	_	_
33	acetate	acetate	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	ionomycin	ionomycin	NN	NN	_	33	conj	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	P/I	p/i	NN	NN	_	33	appos	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	,	,	,	,	_	33	punct	_	_
40	pharmacological	pharmacological	JJ	JJ	_	41	amod	_	_
41	mimics	mimic	NNS	NNS	_	33	appos	_	_
42	of	of	IN	IN	_	45	case	_	_
43	T-cell	t-cell	NN	NN	_	45	compound	_	_
44	receptor	receptor	NN	NN	_	45	compound	_	_
45	activation	activation	NN	NN	_	41	nmod	_	_
46	.	.	.	.	_	13	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	resting	rest	VBG	VBG	_	4	amod	_	_
3	Jurkat	jurkat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	11	advcl	_	_
6	Fas	fas	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	11	punct	_	_
8	Fas	fas	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	0	root	_	_
12	approximately	approximately	RB	RB	_	13	advmod	_	_
13	10-fold	10-fold	RB	RB	_	11	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	2	2	CD	CD	_	16	nummod	_	_
16	h	h	NN	NN	_	11	nmod	_	_
17	upon	upon	IN	IN	_	19	case	_	_
18	P/I	p/i	NN	NN	_	19	compound	_	_
19	stimulation	stimulation	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Using	use	VBG	VBG	_	16	advcl	_	_
2	sequential	sequential	JJ	JJ	_	4	amod	_	_
3	deletion	deletion	NN	NN	_	4	compound	_	_
4	mutants	mutant	NNS	NNS	_	1	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	fas	fas	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	transient	transient	JJ	JJ	_	13	amod	_	_
12	transfection	transfection	NN	NN	_	13	compound	_	_
13	assays	assay	NNS	NNS	_	1	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	identified	identify	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	47-bp	47-bp	JJ	JJ	_	19	amod	_	_
19	sequence	sequence	NN	NN	_	16	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	positions	position	NNS	NNS	_	19	appos	_	_
22	-306	-306	CD	CD	_	21	dep	_	_
23	to	to	TO	TO	_	22	dep	_	_
24	-260	-260	CD	CD	_	22	dep	_	_
25	relative	relative	JJ	JJ	_	28	case	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	ATG	atg	NN	NN	_	21	nmod	_	_
29	)	)	-RRB-	-RRB-	_	21	punct	_	_
30	required	require	VBN	VBN	_	19	acl	_	_
31	for	for	IN	IN	_	34	case	_	_
32	activation-driven	activation-driven	JJ	JJ	_	34	amod	_	_
33	fas	fas	NN	NN	_	34	compound	_	_
34	upregulation	upregulation	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	16	punct	_	_

1	Sequence	sequence	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	12	case	_	_
7	a	a	DT	DT	_	12	det	_	_
8	previously	previously	RB	RB	_	12	advmod	_	_
9	unrecognized	unrecognized	JJ	JJ	_	12	amod	_	_
10	composite	composite	JJ	JJ	_	12	amod	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	5	nmod	_	_
13	for	for	IN	IN	_	16	case	_	_
14	both	both	CC	CC	_	16	cc:preconj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	Sp1	sp1	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	16	conj	_	_
21	at	at	IN	IN	_	22	case	_	_
22	positions	position	NNS	NNS	_	16	nmod	_	_
23	-295	-295	CD	CD	_	22	dep	_	_
24	to	to	TO	TO	_	23	dep	_	_
25	-286	-286	CD	CD	_	23	dep	_	_
26	.	.	.	.	_	3	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	14	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSA	emsa	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	supershift	supershift	NN	NN	_	10	compound	_	_
10	analyses	analysis	NNS	NNS	_	4	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	this	this	DT	DT	_	13	det	_	_
13	region	region	NN	NN	_	10	nmod	_	_
14	documented	document	VBD	VBD	_	0	root	_	_
15	constitutive	constitutive	JJ	JJ	_	16	amod	_	_
16	binding	binding	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Sp1	sp1	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	unactivated	unactivated	JJ	JJ	_	22	amod	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	extracts	extract	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	16	cc	_	_
24	inducible	inducible	JJ	JJ	_	25	amod	_	_
25	binding	binding	NN	NN	_	16	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	p50-p65	p50-p65	NN	NN	_	29	compound	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	29	compound	_	_
29	heterodimers	heterodimer	NNS	NNS	_	25	nmod	_	_
30	after	after	IN	IN	_	32	case	_	_
31	P/I	p/i	NN	NN	_	32	compound	_	_
32	activation	activation	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Sp1	sp1	NN	NN	_	6	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	1	conj	_	_
4	transcription	transcription	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	12	mark	_	_
10	be	be	VB	VB	_	12	cop	_	_
11	mutually	mutually	RB	RB	_	12	advmod	_	_
12	exclusive	exclusive	JJ	JJ	_	8	xcomp	_	_
13	by	by	IN	IN	_	16	case	_	_
14	EMSA	emsa	NN	NN	_	16	compound	_	_
15	displacement	displacement	NN	NN	_	16	compound	_	_
16	studies	study	NNS	NNS	_	8	nmod	_	_
17	with	with	IN	IN	_	16	dep	_	_
18	purified	purify	VBN	VBN	_	20	amod	_	_
19	recombinant	recombinant	JJ	JJ	_	20	amod	_	_
20	Sp1	sp1	NN	NN	_	17	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	recombinant	recombinant	JJ	JJ	_	23	amod	_	_
23	p50	p50	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	contribution	contribution	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	kappaB-Sp1	kappab-sp1	NN	NN	_	8	compound	_	_
7	composite	composite	JJ	JJ	_	8	amod	_	_
8	site	site	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	P/I-inducible	p/i-inducible	JJ	JJ	_	13	amod	_	_
11	fas	fas	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	3	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	verified	verify	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	15	advcl	_	_
18	kappaB-Sp1	kappab-sp1	NN	NN	_	19	compound	_	_
19	concatamers	concatamer	NNS	NNS	_	17	dobj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	-295	-295	CD	CD	_	19	dep	_	_
22	to	to	TO	TO	_	21	dep	_	_
23	-286	-286	CD	CD	_	21	dep	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	in	in	IN	IN	_	31	case	_	_
26	a	a	DT	DT	_	31	det	_	_
27	thymidine	thymidine	NN	NN	_	31	compound	_	_
28	kinase	kinase	NN	NN	_	31	compound	_	_
29	promoter-driven	promoter-driven	JJ	JJ	_	31	amod	_	_
30	reporter	reporter	NN	NN	_	31	compound	_	_
31	construct	construct	NN	NN	_	19	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	native	native	JJ	JJ	_	35	amod	_	_
34	promoter	promoter	NN	NN	_	35	compound	_	_
35	constructs	construct	NNS	NNS	_	31	conj	_	_
36	in	in	IN	IN	_	38	case	_	_
37	Jurkat	jurkat	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	31	nmod	_	_
39	overexpressing	overexpress	VBG	VBG	_	38	acl	_	_
40	IkappaB-alpha	ikappab-alpha	NN	NN	_	39	dobj	_	_
41	.	.	.	.	_	15	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	critical	critical	JJ	JJ	_	7	amod	_	_
6	guanine	guanine	NN	NN	_	7	compound	_	_
7	nucleotides	nucleotide	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	kappaB-Sp1	kappab-sp1	NN	NN	_	11	compound	_	_
11	element	element	NN	NN	_	7	nmod	_	_
12	documented	document	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	essential	essential	JJ	JJ	_	15	amod	_	_
15	role	role	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	site	site	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	activation-dependent	activation-dependent	JJ	JJ	_	23	amod	_	_
21	fas	fas	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	induction	induction	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	RFLAT-1	rflat-1	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	a	a	DT	DT	_	8	det	_	_
4	new	new	JJ	JJ	_	8	amod	_	_
5	zinc	zinc	NN	NN	_	8	compound	_	_
6	finger	finger	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	dep	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	activates	activate	VBZ	VBZ	_	8	acl:relcl	_	_
11	RANTES	rantes	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	RANTES	rantes	NN	NN	_	17	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	9	punct	_	_
3	Regulated	regulate	VBN	VBN	_	9	amod	_	_
4	upon	upon	IN	IN	_	5	case	_	_
5	Activation	activation	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	Normal	normal	JJ	JJ	_	3	dep	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cell	cell	NN	NN	_	1	dep	_	_
10	Expressed	express	VBN	VBN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Secreted	secrete	VBN	VBN	_	10	conj	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	chemoattractant	chemoattractant	NN	NN	_	17	compound	_	_
17	cytokine	cytokine	NN	NN	_	0	root	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	chemokine	chemokine	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	important	important	JJ	JJ	_	17	amod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	generation	generation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
27	infiltrate	infiltrate	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	human	human	JJ	JJ	_	32	amod	_	_
30	immunodeficiency	immunodeficiency	NN	NN	_	32	compound	_	_
31	virus	virus	NN	NN	_	32	compound	_	_
32	entry	entry	NN	NN	_	24	conj	_	_
33	into	into	IN	IN	_	35	case	_	_
34	immune	immune	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	RANTES	rantes	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	late	late	RB	RB	_	3	advmod	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	3-5	3-5	CD	CD	_	7	nummod	_	_
7	days	day	NNS	NNS	_	4	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	after	after	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	3	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	cloning	cloning	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	15	det	_	_
8	first	first	JJ	JJ	_	15	amod	_	_
9	``	``	``	``	_	15	punct	_	_
10	late	late	JJ	JJ	_	15	amod	_	_
11	T	t	NN	NN	_	15	compound	_	_
12	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
13	associated	associated	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	6	dobj	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	named	name	VBD	VBD	_	6	conj	_	_
18	it	it	PRP	PRP	_	26	nsubj	_	_
19	``	``	``	``	_	26	punct	_	_
20	RANTES	rantes	NN	NN	_	26	compound	_	_
21	Factor	factor	NN	NN	_	26	compound	_	_
22	of	of	IN	IN	_	26	amod	_	_
23	Late	late	JJ	JJ	_	26	amod	_	_
24	Activated	activate	VBN	VBN	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	Lymphocytes-1	lymphocytes-1	NNS	NNS	_	17	xcomp	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	RFLAT-1	rflat-1	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	6	punct	_	_

1	RFLAT-1	rflat-1	NN	NN	_	11	nsubj	_	_
2	is	be	VBZ	VBZ	_	11	cop	_	_
3	a	a	DT	DT	_	11	det	_	_
4	novel	novel	JJ	JJ	_	11	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	phosphorylated	phosphorylate	VBN	VBN	_	4	dep	_	_
7	,	,	,	,	_	4	punct	_	_
8	zinc	zinc	NN	NN	_	9	compound	_	_
9	finger	finger	NN	NN	_	4	dep	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	expressed	express	VBN	VBN	_	11	acl:relcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	3	3	CD	CD	_	19	nummod	_	_
19	days	day	NNS	NNS	_	14	nmod	_	_
20	after	after	IN	IN	_	19	case	_	_
21	activation	activation	NN	NN	_	19	dep	_	_
22	,	,	,	,	_	14	punct	_	_
23	coincident	coincident	JJ	JJ	_	14	xcomp	_	_
24	with	with	IN	IN	_	26	case	_	_
25	RANTES	rantes	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	While	while	IN	IN	_	4	mark	_	_
2	Rel	rel	NN	NN	_	3	compound	_	_
3	proteins	protein	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	19	advcl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	dominant	dominant	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	RANTES	rantes	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	fibroblasts	fibroblast	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	RFLAT-1	rflat-1	NN	NN	_	19	nsubj	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	strong	strong	JJ	JJ	_	19	amod	_	_
19	transactivator	transactivator	NN	NN	_	0	root	_	_
20	for	for	IN	IN	_	21	case	_	_
21	RANTES	rantes	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	Daidzein	daidzein	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	genistein	genistein	NN	NN	_	1	conj	_	_
4	glucuronides	glucuronide	NNS	NNS	_	9	nsubj	_	_
5	in	in	FW	FW	_	6	compound	_	_
6	vitro	vitro	FW	FW	_	4	advmod	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	weakly	weakly	RB	RB	_	9	advmod	_	_
9	estrogenic	estrogenic	JJ	JJ	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	activate	activate	VBP	VBP	_	9	conj	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	natural	natural	JJ	JJ	_	15	amod	_	_
14	killer	killer	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	dobj	_	_
16	at	at	IN	IN	_	19	case	_	_
17	nutritionally	nutritionally	RB	RB	_	18	advmod	_	_
18	relevant	relevant	JJ	JJ	_	19	amod	_	_
19	concentrations	concentration	NNS	NNS	_	11	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Daidzein	daidzein	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	genistein	genistein	NN	NN	_	1	conj	_	_
4	glucuronides	glucuronide	NNS	NNS	_	18	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	DG	dg	NNS	NNS	_	4	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	GG	gg	NNS	NNS	_	6	conj	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	,	,	,	,	_	4	punct	_	_
11	major	major	JJ	JJ	_	13	amod	_	_
12	isoflavone	isoflavone	NN	NN	_	13	compound	_	_
13	metabolites	metabolite	NNS	NNS	_	4	appos	_	_
14	,	,	,	,	_	4	punct	_	_
15	may	may	MD	MD	_	18	aux	_	_
16	be	be	VB	VB	_	18	cop	_	_
17	partly	partly	RB	RB	_	18	advmod	_	_
18	responsible	responsible	JJ	JJ	_	0	root	_	_
19	for	for	IN	IN	_	21	case	_	_
20	biological	biological	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	isoflavones	isoflavone	NNS	NNS	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	such	such	JJ	JJ	_	29	case	_	_
26	as	as	IN	IN	_	25	mwe	_	_
27	estrogen	estrogen	NN	NN	_	29	compound	_	_
28	receptor	receptor	NN	NN	_	29	compound	_	_
29	binding	binding	NN	NN	_	21	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	natural	natural	JJ	JJ	_	33	amod	_	_
32	killer	killer	NN	NN	_	33	compound	_	_
33	cell	cell	NN	NN	_	29	conj	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	NK	nk	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	activation	activation	NN	NN	_	33	dep	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	inhibition	inhibition	NN	NN	_	37	conj	_	_
40	.	.	.	.	_	18	punct	_	_

1	DG	dg	NNS	NNS	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	GG	gg	NNS	NNS	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	synthesized	synthesize	VBN	VBN	_	0	root	_	_
6	using	use	VBG	VBG	_	5	xcomp	_	_
7	3-methylcholanthrene-induced	3-methylcholanthrene-induced	JJ	JJ	_	10	amod	_	_
8	rat	rat	NN	NN	_	10	compound	_	_
9	liver	liver	NN	NN	_	10	compound	_	_
10	microsomes	microsome	NNS	NNS	_	6	dobj	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	Km	km	NN	NN	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	Vmax	vmax	NN	NN	_	2	conj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	daidzein	daidzein	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	genistein	genistein	NN	NN	_	6	conj	_	_
9	were	be	VBD	VBD	_	13	cop	_	_
10	9.0	9.0	CD	CD	_	13	nummod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	7.7	7.7	CD	CD	_	10	conj	_	_
13	micromol/L	micromol/l	NN	NN	_	0	root	_	_
14	,	,	,	,	_	13	punct	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	0.7	0.7	CD	CD	_	23	nummod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	1.6	1.6	CD	CD	_	16	conj	_	_
19	micromol/	micromol/	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	23	punct	_	_
21	mg	mg	NN	NN	_	23	compound	_	_
22	protein.	protein.	NN	NN	_	23	compound	_	_
23	min	min	NN	NN	_	13	conj	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	13	punct	_	_
26	respectively	respectively	RB	RB	_	13	advmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	absence	absence	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	ultraviolet	ultraviolet	JJ	JJ	_	7	amod	_	_
5	absorbance	absorbance	NN	NN	_	7	compound	_	_
6	maxima	maximum	NNS	NNS	_	7	compound	_	_
7	shifts	shift	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	dep	_	_
10	presence	presence	NN	NN	_	13	dep	_	_
11	of	of	IN	IN	_	13	case	_	_
12	sodium	sodium	NN	NN	_	13	compound	_	_
13	acetate	acetate	NN	NN	_	2	nmod	_	_
14	confirmed	confirm	VBD	VBD	_	0	root	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	the	the	DT	DT	_	18	det	_	_
17	synthesized	synthesize	VBN	VBN	_	18	amod	_	_
18	products	product	NNS	NNS	_	20	nsubj	_	_
19	were	be	VBD	VBD	_	20	cop	_	_
20	7-O-glucuronides	7-o-glucuronide	NNS	NNS	_	14	ccomp	_	_
21	.	.	.	.	_	14	punct	_	_

1	DG	dg	NNS	NNS	_	6	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	GG	gg	NNS	NNS	_	1	conj	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	further	further	RB	RB	_	6	advmod	_	_
6	purified	purify	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	Sephadex	sephadex	NN	NN	_	11	compound	_	_
10	LH-20	lh-20	NN	NN	_	11	compound	_	_
11	column	column	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	DG	dg	NNS	NNS	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	GG	gg	NNS	NNS	_	1	conj	_	_
4	competed	compete	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	17beta-(3H)	17beta-(3h)	JJ	JJ	_	10	amod	_	_
10	estradiol	estradiol	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	estrogen	estrogen	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	B6D2F1	b6d2f1	NN	NN	_	18	compound	_	_
16	mouse	mouse	NN	NN	_	18	compound	_	_
17	uterine	uterine	NN	NN	_	18	compound	_	_
18	cytosol	cytosol	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentrations	concentration	NNS	NNS	_	16	nsubj	_	_
3	required	require	VBN	VBN	_	2	acl	_	_
4	for	for	IN	IN	_	7	case	_	_
5	50	50	CD	CD	_	6	compound	_	_
6	%	%	NN	NN	_	7	amod	_	_
7	displacement	displacement	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	17beta-(3H)	17beta-(3h)	JJ	JJ	_	10	amod	_	_
10	estradiol	estradiol	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	CB50	cb50	NN	NN	_	7	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	were	be	VBD	VBD	_	16	cop	_	_
15	:	:	:	:	_	16	punct	_	_
16	17beta-estradiol	17beta-estradiol	NN	NN	_	0	root	_	_
17	,	,	,	,	_	16	punct	_	_
18	1.34	1.34	CD	CD	_	19	nummod	_	_
19	nmol/L	nmol/l	NN	NN	_	16	appos	_	_
20	;	;	:	:	_	16	punct	_	_
21	diethylstilbestrol	diethylstilbestrol	NN	NN	_	16	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	1.46	1.46	CD	CD	_	24	nummod	_	_
24	nmol/L	nmol/l	NN	NN	_	21	appos	_	_
25	;	;	:	:	_	16	punct	_	_
26	daidzein	daidzein	NN	NN	_	16	dep	_	_
27	,	,	,	,	_	26	punct	_	_
28	1.6	1.6	CD	CD	_	29	nummod	_	_
29	micromol/L	micromol/l	NN	NN	_	26	appos	_	_
30	;	;	:	:	_	16	punct	_	_
31	DG	dg	NNS	NNS	_	16	dep	_	_
32	,	,	,	,	_	31	punct	_	_
33	14.7	14.7	CD	CD	_	34	nummod	_	_
34	micromol/L	micromol/l	NN	NN	_	31	appos	_	_
35	;	;	:	:	_	16	punct	_	_
36	genistein	genistein	NN	NN	_	16	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	0.154	0.154	CD	CD	_	39	nummod	_	_
39	micromol/L	micromol/l	NN	NN	_	36	appos	_	_
40	;	;	:	:	_	16	punct	_	_
41	GG	gg	NNS	NNS	_	16	dep	_	_
42	,	,	,	,	_	41	punct	_	_
43	7.27	7.27	CD	CD	_	44	nummod	_	_
44	micromol/L	micromol/l	NN	NN	_	41	appos	_	_
45	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
4	blood	blood	NN	NN	_	6	compound	_	_
5	NK	nk	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	20	nmod	_	_
7	,	,	,	,	_	20	punct	_	_
8	genistein	genistein	NN	NN	_	20	nsubj	_	_
9	at	at	IN	IN	_	12	case	_	_
10	&lt;	&lt;	JJR	JJR	_	11	advmod	_	_
11	0.5	0.5	CD	CD	_	12	nummod	_	_
12	micromol/L	micromol/l	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	DG	dg	NNS	NNS	_	8	conj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	GG	gg	NNS	NNS	_	14	conj	_	_
17	at	at	IN	IN	_	19	case	_	_
18	0.1-10	0.1-10	CD	CD	_	19	nummod	_	_
19	micromol/L	micromol/l	NN	NN	_	14	nmod	_	_
20	enhanced	enhance	VBD	VBD	_	0	root	_	_
21	NK	nk	NN	NN	_	22	nmod:npmod	_	_
22	cell-mediated	cell-mediated	JJ	JJ	_	26	amod	_	_
23	K562	k562	NN	NN	_	26	compound	_	_
24	cancer	cancer	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	killing	killing	NN	NN	_	20	dobj	_	_
27	significantly	significantly	RB	RB	_	20	advmod	_	_
28	(	(	-LRB-	-LRB-	_	30	punct	_	_
29	P	p	NN	NN	_	30	dep	_	_
30	&lt;	&lt;	JJR	JJR	_	20	parataxis	_	_
31	0.05	0.05	CD	CD	_	30	nummod	_	_
32	)	)	-RRB-	-RRB-	_	30	punct	_	_
33	.	.	.	.	_	20	punct	_	_

1	At	at	IN	IN	_	4	case	_	_
2	&gt;	&gt;	JJR	JJR	_	3	advmod	_	_
3	0.5	0.5	CD	CD	_	4	nummod	_	_
4	micromol/L	micromol/l	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	genistein	genistein	NN	NN	_	7	nsubj	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	NK	nk	NN	NN	_	9	compound	_	_
9	cytotoxicity	cytotoxicity	NN	NN	_	7	dobj	_	_
10	significantly	significantly	RB	RB	_	7	advmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	P	p	NN	NN	_	13	dep	_	_
13	&lt;	&lt;	JJR	JJR	_	7	parataxis	_	_
14	0.05	0.05	CD	CD	_	13	nummod	_	_
15	)	)	-RRB-	-RRB-	_	13	punct	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	glucuronides	glucuronide	NNS	NNS	_	4	nsubj	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	NK	nk	NN	NN	_	6	compound	_	_
6	cytotoxicity	cytotoxicity	NN	NN	_	4	dobj	_	_
7	at	at	IN	IN	_	9	case	_	_
8	50	50	CD	CD	_	9	nummod	_	_
9	micromol/L	micromol/l	NN	NN	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Isoflavones	isoflavone	NNS	NNS	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	and	and	CC	CC	_	1	cc	_	_
4	especially	especially	RB	RB	_	7	advmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	isoflavone	isoflavone	NN	NN	_	7	compound	_	_
7	glucuronides	glucuronide	NNS	NNS	_	1	conj	_	_
8	,	,	,	,	_	1	punct	_	_
9	enhanced	enhance	VBD	VBD	_	0	root	_	_
10	activation	activation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	NK	nk	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	15	case	_	_
15	interleukin-2	interleukin-2	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IL-2	il-2	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	9	punct	_	_
20	additively	additively	RB	RB	_	9	advmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	At	at	IN	IN	_	3	case	_	_
2	physiological	physiological	JJ	JJ	_	3	amod	_	_
3	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	DG	dg	NNS	NNS	_	10	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	GG	gg	NNS	NNS	_	5	conj	_	_
8	were	be	VBD	VBD	_	10	cop	_	_
9	weakly	weakly	RB	RB	_	10	advmod	_	_
10	estrogenic	estrogenic	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	they	they	PRP	PRP	_	14	nsubj	_	_
14	activated	activate	VBD	VBD	_	10	conj	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	NK	nk	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	nutritionally	nutritionally	RB	RB	_	20	advmod	_	_
20	relevant	relevant	JJ	JJ	_	21	amod	_	_
21	concentrations	concentration	NNS	NNS	_	14	nmod	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vitro	vitro	FW	FW	_	21	advmod	_	_
24	,	,	,	,	_	14	punct	_	_
25	probably	probably	RB	RB	_	28	advmod	_	_
26	at	at	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	site	site	NN	NN	_	14	nmod	_	_
29	different	different	JJ	JJ	_	28	amod	_	_
30	from	from	IN	IN	_	32	case	_	_
31	IL-2	il-2	NN	NN	_	32	compound	_	_
32	action	action	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	10	punct	_	_

1	Osteoclast	osteoclast	NN	NN	_	2	compound	_	_
2	markers	marker	NNS	NNS	_	3	nsubj	_	_
3	accumulate	accumulate	VBP	VBP	_	0	root	_	_
4	on	on	IN	IN	_	5	case	_	_
5	cells	cell	NNS	NNS	_	3	nmod	_	_
6	developing	develop	VBG	VBG	_	5	acl	_	_
7	from	from	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	precursors	precursor	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	osteoclasts	osteoclast	NNS	NNS	_	7	nsubj	_	_
7	develop	develop	VBP	VBP	_	3	ccomp	_	_
8	in	in	FW	FW	_	9	compound	_	_
9	vitro	vitro	FW	FW	_	7	advmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	;	;	:	:	_	3	punct	_	_
14	however	however	RB	RB	_	3	advmod	_	_
15	,	,	,	,	_	3	punct	_	_
16	special	special	JJ	JJ	_	18	amod	_	_
17	cultures	culture	NNS	NNS	_	18	compound	_	_
18	conditions	condition	NNS	NNS	_	26	nsubjpass	_	_
19	and/or	and/or	CC	CC	_	18	cc	_	_
20	cytokine	cytokine	NN	NN	_	21	dep	_	_
21	mobilized	mobilize	VBN	VBN	_	23	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
23	blood	blood	NN	NN	_	18	conj	_	_
24	are	be	VBP	VBP	_	26	auxpass	_	_
25	apparently	apparently	RB	RB	_	26	advmod	_	_
26	required	require	VBN	VBN	_	3	dep	_	_
27	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	cells	cell	NNS	NNS	_	10	nsubj	_	_
7	expressing	express	VBG	VBG	_	6	acl	_	_
8	osteoclast	osteoclast	NN	NN	_	9	compound	_	_
9	markers	marker	NNS	NNS	_	7	dobj	_	_
10	differentiate	differentiate	VBP	VBP	_	4	ccomp	_	_
11	from	from	IN	IN	_	12	case	_	_
12	precursors	precursor	NNS	NNS	_	10	nmod	_	_
13	present	present	JJ	JJ	_	12	amod	_	_
14	in	in	IN	IN	_	19	case	_	_
15	nonmobilized	nonmobilized	JJ	JJ	_	19	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
17	blood	blood	NN	NN	_	19	compound	_	_
18	mononuclear	mononuclear	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PBMC	pbmc	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	10	punct	_	_
24	without	without	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	addition	addition	NN	NN	_	10	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	stromal	stromal	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	growth	growth	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	29	conj	_	_
33	,	,	,	,	_	29	punct	_	_
34	cytokines	cytokine	NNS	NNS	_	29	conj	_	_
35	or	or	CC	CC	_	29	cc	_	_
36	steroids	steroid	NNS	NNS	_	29	conj	_	_
37	;	;	:	:	_	10	punct	_	_
38	and	and	CC	CC	_	10	cc	_	_
39	characterize	characterize	VBP	VBP	_	10	conj	_	_
40	their	they	PRP$	PRP$	_	41	nmod:poss	_	_
41	phenotype	phenotype	NN	NN	_	39	dobj	_	_
42	.	.	.	.	_	4	punct	_	_

1	Three	three	CD	CD	_	2	nummod	_	_
2	days	day	NNS	NNS	_	32	dep	_	_
3	after	after	IN	IN	_	2	mark	_	_
4	establishing	establish	VBG	VBG	_	2	dep	_	_
5	high-density	high-density	JJ	JJ	_	7	amod	_	_
6	PBMC	pbmc	NN	NN	_	7	compound	_	_
7	cultures	culture	NNS	NNS	_	4	dobj	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	1.5	1.5	CD	CD	_	12	nummod	_	_
10	x	x	CC	CC	_	9	cc	_	_
11	10(6)	10(6)	CD	CD	_	9	conj	_	_
12	cells/cm2	cells/cm2	NNS	NNS	_	7	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	4	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	serum-containing	serum-containing	JJ	JJ	_	17	amod	_	_
17	medium	medium	JJ	JJ	_	4	nmod	_	_
18	,	,	,	,	_	32	punct	_	_
19	small	small	JJ	JJ	_	21	amod	_	_
20	adherent	adherent	JJ	JJ	_	21	amod	_	_
21	colonies	colony	NNS	NNS	_	32	nsubj	_	_
22	of	of	IN	IN	_	31	case	_	_
23	tartrate	tartrate	JJ	JJ	_	31	amod	_	_
24	resistant	resistant	JJ	JJ	_	31	amod	_	_
25	acid	acid	NN	NN	_	31	compound	_	_
26	phosphatase	phosphatase	NN	NN	_	31	compound	_	_
27	positive	positive	JJ	JJ	_	31	amod	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	TRAP+	trap+	JJ	JJ	_	31	amod	_	_
30	)	)	-RRB-	-RRB-	_	31	punct	_	_
31	cells	cell	NNS	NNS	_	21	nmod	_	_
32	emerge	emerge	VBP	VBP	_	0	root	_	_
33	,	,	,	,	_	32	punct	_	_
34	amidst	amidst	IN	IN	_	38	case	_	_
35	massive	massive	JJ	JJ	_	38	amod	_	_
36	monocyte	monocyte	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	death	death	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	32	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	adherent	adherent	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	have	have	VBP	VBP	_	0	root	_	_
5	an	a	DT	DT	_	10	det	_	_
6	eccentrically	eccentrically	RB	RB	_	7	advmod	_	_
7	placed	placed	JJ	JJ	_	10	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	round	round	JJ	JJ	_	7	dep	_	_
10	nucleus	nucleus	NN	NN	_	4	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	express	express	VB	VB	_	4	conj	_	_
14	low	low	JJ	JJ	_	15	amod	_	_
15	levels	level	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	TRAP	trap	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	sodium	sodium	NN	NN	_	20	compound	_	_
20	fluoride-resistant-alpha-naphthyl-acetate-esterase	fluoride-resistant-alpha-naphthyl-acetate-esterase	NN	NN	_	17	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NaF-R-NSE	naf-r-nse	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	4	punct	_	_

1	Over	over	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	next	next	JJ	JJ	_	4	amod	_	_
4	week	week	NN	NN	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	this	this	DT	DT	_	8	det	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	population	population	NN	NN	_	9	nsubj	_	_
9	accumulates	accumulate	VBZ	VBZ	_	0	root	_	_
10	phenotypic	phenotypic	JJ	JJ	_	11	amod	_	_
11	markers	marker	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	osteoclasts	osteoclast	NNS	NNS	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	vitronectin	vitronectin	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	13	dep	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	VR	vr	NN	NN	_	16	appos	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	16	punct	_	_
21	calcitonin	calcitonin	NN	NN	_	22	compound	_	_
22	receptor	receptor	NN	NN	_	16	conj	_	_
23	,	,	,	,	_	16	punct	_	_
24	TRAP	trap	NN	NN	_	16	conj	_	_
25	,	,	,	,	_	16	punct	_	_
26	cathepsin	cathepsin	NN	NN	_	28	compound	_	_
27	K	k	NN	NN	_	28	compound	_	_
28	protein	protein	NN	NN	_	16	conj	_	_
29	,	,	,	,	_	16	punct	_	_
30	and	and	CC	CC	_	16	cc	_	_
31	mRNA	mrna	NN	NN	_	16	conj	_	_
32	)	)	-RRB-	-RRB-	_	16	punct	_	_
33	with	with	IN	IN	_	35	case	_	_
34	increased	increase	VBN	VBN	_	35	amod	_	_
35	nuclearity	nuclearity	NN	NN	_	13	nmod	_	_
36	,	,	,	,	_	9	punct	_	_
37	covering	cover	VBG	VBG	_	9	advcl	_	_
38	the	the	DT	DT	_	40	det	_	_
39	entire	entire	JJ	JJ	_	40	amod	_	_
40	surface	surface	NN	NN	_	37	dobj	_	_
41	by	by	IN	IN	_	43	case	_	_
42	15	15	CD	CD	_	43	nummod	_	_
43	days	day	NNS	NNS	_	37	nmod	_	_
44	.	.	.	.	_	9	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	cultured	culture	VBN	VBN	_	13	advcl	_	_
3	on	on	IN	IN	_	4	case	_	_
4	bone	bone	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	13	punct	_	_
6	VR+	vr+	JJ	JJ	_	9	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	TRAP+	trap+	JJ	JJ	_	6	dep	_	_
9	cells	cell	NNS	NNS	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	multinuclearity	multinuclearity	NN	NN	_	9	nmod	_	_
13	appear	appear	VBP	VBP	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cover	cover	VBP	VBP	_	13	conj	_	_
16	up	up	RB	RB	_	18	advmod	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	50	50	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	15	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	surface	surface	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Resorption	resorption	NN	NN	_	2	compound	_	_
2	lacunae	lacuna	NNS	NNS	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	day	day	NN	NN	_	5	nmod	_	_
8	22	22	CD	CD	_	7	nummod	_	_
9	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	these	these	DT	DT	_	3	det	_	_
3	pits	pit	NNS	NNS	_	8	nsubj	_	_
4	are	be	VBP	VBP	_	8	cop	_	_
5	not	not	RB	RB	_	8	neg	_	_
6	nearly	nearly	RB	RB	_	8	advmod	_	_
7	as	as	IN	IN	_	8	dep	_	_
8	numerous	numerous	JJ	JJ	_	18	advcl	_	_
9	as	as	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	preosteoclast	preosteoclast	JJ	JJ	_	14	amod	_	_
14	phenotype	phenotype	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	18	punct	_	_
16	they	they	PRP	PRP	_	18	nsubj	_	_
17	do	do	VBP	VBP	_	18	aux	_	_
18	represent	represent	VB	VB	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	subset	subset	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	osteoclast-like	osteoclast-like	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	has	have	VBZ	VBZ	_	29	aux	_	_
29	achieved	achieve	VBN	VBN	_	23	acl:relcl	_	_
30	osteoclastic	osteoclastic	JJ	JJ	_	31	amod	_	_
31	maturity	maturity	NN	NN	_	29	dobj	_	_
32	under	under	IN	IN	_	35	case	_	_
33	these	these	DT	DT	_	35	det	_	_
34	culture	culture	NN	NN	_	35	compound	_	_
35	conditions	condition	NNS	NNS	_	29	nmod	_	_
36	.	.	.	.	_	18	punct	_	_

1	Transcripts	transcript	NNS	NNS	_	22	nsubjpass	_	_
2	for	for	IN	IN	_	4	case	_	_
3	osteoprotegerin	osteoprotegerin	NN	NN	_	4	compound	_	_
4	ligand	ligand	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	OPGL	opgl	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	an	a	DT	DT	_	12	det	_	_
10	osteoclast	osteoclast	JJ	JJ	_	12	amod	_	_
11	differentiation	differentiation	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	4	appos	_	_
13	(	(	-LRB-	-LRB-	_	12	punct	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	known	know	VBN	VBN	_	12	acl	_	_
16	as	as	IN	IN	_	17	case	_	_
17	RANKL	rankl	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	TRANCE	trance	NN	NN	_	17	conj	_	_
20	)	)	-RRB-	-RRB-	_	12	punct	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	expressed	express	VBN	VBN	_	0	root	_	_
23	,	,	,	,	_	22	punct	_	_
24	likely	likely	RB	RB	_	27	advmod	_	_
25	by	by	IN	IN	_	27	case	_	_
26	adherent	adherent	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	22	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	adherent	adherent	JJ	JJ	_	5	amod	_	_
5	population	population	NN	NN	_	14	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	with	with	IN	IN	_	12	case	_	_
10	preosteoclast/osteoclast	preosteoclast/osteoclast	JJ	JJ	_	12	amod	_	_
11	phenotypic	phenotypic	JJ	JJ	_	12	amod	_	_
12	properties	property	NNS	NNS	_	14	nmod	_	_
13	,	,	,	,	_	14	punct	_	_
14	arises	arise	VBZ	VBZ	_	0	root	_	_
15	selectively	selectively	RB	RB	_	14	advmod	_	_
16	under	under	IN	IN	_	19	case	_	_
17	simple	simple	JJ	JJ	_	19	amod	_	_
18	culture	culture	NN	NN	_	19	compound	_	_
19	conditions	condition	NNS	NNS	_	14	nmod	_	_
20	from	from	IN	IN	_	22	case	_	_
21	normal	normal	JJ	JJ	_	22	amod	_	_
22	PBMC	pbmc	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Further	further	JJ	JJ	_	2	amod	_	_
2	characterization	characterization	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	should	should	MD	MD	_	7	aux	_	_
7	identify	identify	VB	VB	_	0	root	_	_
8	factors	factor	NNS	NNS	_	7	dobj	_	_
9	involved	involve	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	growth	growth	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	activation	activation	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	osteoclasts	osteoclast	NNS	NNS	_	12	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Phenotypic	phenotypic	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	functional	functional	JJ	JJ	_	1	conj	_	_
4	studies	study	NNS	NNS	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	endometrium	endometrium	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	endometriosis	endometriosis	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aetiology	aetiology	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	endometriosis	endometriosis	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	10	det	_	_
7	common	common	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	disabling	disable	VBG	VBG	_	7	conj	_	_
10	disorder	disorder	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	4	punct	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	presently	presently	RB	RB	_	14	advmod	_	_
14	unknown	unknown	JJ	JJ	_	0	root	_	_
15	,	,	,	,	_	14	punct	_	_
16	although	although	IN	IN	_	20	mark	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	dysfunction	dysfunction	NN	NN	_	20	nsubj	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	allow	allow	VB	VB	_	14	advcl	_	_
21	ectopic	ectopic	JJ	JJ	_	23	amod	_	_
22	endometrial	endometrial	JJ	JJ	_	23	amod	_	_
23	fragments	fragment	NNS	NNS	_	20	dobj	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	survive	survive	VB	VB	_	20	xcomp	_	_
26	outside	outside	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	uterine	uterine	JJ	JJ	_	29	amod	_	_
29	cavity	cavity	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	investigate	investigate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	relationship	relationship	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	populations	population	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	steroid	steroid	NN	NN	_	13	compound	_	_
11	hormone	hormone	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	conj	_	_
14	,	,	,	,	_	8	punct	_	_
15	proliferative	proliferative	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	8	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	bcl-2	bcl-2	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	8	conj	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	apoptosis	apoptosis	NN	NN	_	8	conj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	eutopic	eutopic	JJ	JJ	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	ectopic	ectopic	JJ	JJ	_	23	conj	_	_
26	endometrium	endometrium	NN	NN	_	8	nmod	_	_
27	from	from	IN	IN	_	28	case	_	_
28	women	woman	NNS	NNS	_	26	nmod	_	_
29	with	with	IN	IN	_	30	case	_	_
30	endometriosis	endometriosis	NN	NN	_	28	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	adenomyosis	adenomyosis	NN	NN	_	30	conj	_	_
33	at	at	IN	IN	_	35	case	_	_
34	different	different	JJ	JJ	_	35	amod	_	_
35	phases	phase	NNS	NNS	_	28	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	menstrual	menstrual	JJ	JJ	_	39	amod	_	_
39	cycle	cycle	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	3	punct	_	_

1	Significantly	significantly	RB	RB	_	2	advmod	_	_
2	increased	increase	VBN	VBN	_	5	amod	_	_
3	oestrogen	oestrogen	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	15	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	bcl-2	bcl-2	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	conj	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	numbers	number	NNS	NNS	_	5	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD8+	cd8+	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	10	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	found	find	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	ectopic	ectopic	JJ	JJ	_	15	nmod	_	_
18	compared	compare	VBN	VBN	_	21	case	_	_
19	with	with	IN	IN	_	21	case	_	_
20	eutopic	eutopic	JJ	JJ	_	21	amod	_	_
21	endometrium	endometrium	NN	NN	_	15	advcl	_	_
22	in	in	IN	IN	_	23	case	_	_
23	endometriosis	endometriosis	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	CD56+	cd56+	JJ	JJ	_	29	amod	_	_
27	endometrial	endometrial	JJ	JJ	_	29	amod	_	_
28	granulated	granulated	JJ	JJ	_	29	amod	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	35	nsubjpass	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	eGLs	egl	NNS	NNS	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	were	be	VBD	VBD	_	35	auxpass	_	_
34	significantly	significantly	RB	RB	_	35	advmod	_	_
35	reduced	reduce	VBN	VBN	_	15	conj	_	_
36	in	in	IN	IN	_	38	case	_	_
37	ectopic	ectopic	JJ	JJ	_	38	amod	_	_
38	endometrium	endometrium	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	15	punct	_	_

1	Apoptotic	apoptotic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
3	were	be	VBD	VBD	_	5	auxpass	_	_
4	rarely	rarely	RB	RB	_	5	advmod	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	control	control	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	subject	subject	NN	NN	_	7	conj	_	_
10	endometria	endometria	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	with	with	IN	IN	_	4	case	_	_
4	endometriosis	endometriosis	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	adenomyotic	adenomyotic	JJ	JJ	_	7	amod	_	_
7	lesions	lesion	NNS	NNS	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	identical	identical	JJ	JJ	_	13	amod	_	_
10	steroid	steroid	NN	NN	_	13	compound	_	_
11	hormone	hormone	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	proliferative	proliferative	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	bcl-2	bcl-2	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	13	conj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	leukocyte	leukocyte	NN	NN	_	22	compound	_	_
22	subpopulations	subpopulation	NNS	NNS	_	13	conj	_	_
23	to	to	TO	TO	_	25	case	_	_
24	eutopic	eutopic	JJ	JJ	_	25	amod	_	_
25	endometrium	endometrium	NN	NN	_	8	nmod	_	_
26	,	,	,	,	_	8	punct	_	_
27	indicating	indicate	VBG	VBG	_	8	advcl	_	_
28	different	different	JJ	JJ	_	29	amod	_	_
29	aetiologies	aetiology	NNS	NNS	_	27	dobj	_	_
30	for	for	IN	IN	_	32	case	_	_
31	these	these	DT	DT	_	32	det	_	_
32	disorders	disorder	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	unusual	unusual	JJ	JJ	_	5	amod	_	_
3	CD56+	cd56+	JJ	JJ	_	5	amod	_	_
4	CD16-	cd16-	JJ	JJ	_	5	amod	_	_
5	eGLs	egl	NNS	NNS	_	18	nsubjpass	_	_
6	present	present	JJ	JJ	_	5	amod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	large	large	JJ	JJ	_	9	amod	_	_
9	numbers	number	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	late	late	JJ	JJ	_	15	amod	_	_
12	secretory	secretory	JJ	JJ	_	15	amod	_	_
13	phase	phase	NN	NN	_	15	compound	_	_
14	eutopic	eutopic	JJ	JJ	_	15	amod	_	_
15	endometrium	endometrium	NN	NN	_	6	nmod	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	purified	purify	VBN	VBN	_	0	root	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	&gt;	&gt;	JJR	JJR	_	21	advmod	_	_
21	98	98	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	18	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	by	by	IN	IN	_	26	case	_	_
25	immunomagnetic	immunomagnetic	JJ	JJ	_	26	amod	_	_
26	separation	separation	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	18	punct	_	_

1	Except	except	IN	IN	_	6	case	_	_
2	for	for	IN	IN	_	6	case	_	_
3	a	a	DT	DT	_	6	det	_	_
4	negligible	negligible	JJ	JJ	_	6	amod	_	_
5	cytotoxic	cytotoxic	JJ	JJ	_	6	amod	_	_
6	activity	activity	NN	NN	_	26	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	eGLs	egl	NNS	NNS	_	6	nmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	early	early	JJ	JJ	_	12	amod	_	_
11	proliferative	proliferative	JJ	JJ	_	12	amod	_	_
12	samples	sample	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	26	punct	_	_
14	cytotoxic	cytotoxic	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	26	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	eGLs	egl	NNS	NNS	_	15	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	non-pregnant	non-pregnant	JJ	JJ	_	20	amod	_	_
20	endometrium	endometrium	NN	NN	_	17	nmod	_	_
21	during	during	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	menstrual	menstrual	JJ	JJ	_	24	amod	_	_
24	cycle	cycle	NN	NN	_	20	nmod	_	_
25	was	be	VBD	VBD	_	26	cop	_	_
26	comparable	comparable	JJ	JJ	_	0	root	_	_
27	with	with	IN	IN	_	28	case	_	_
28	those	those	DT	DT	_	26	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	peripheral	peripheral	JJ	JJ	_	31	amod	_	_
31	blood	blood	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	28	punct	_	_
33	predominantly	predominantly	RB	RB	_	38	advmod	_	_
34	CD56+	cd56+	JJ	JJ	_	38	amod	_	_
35	CD16+	cd16+	JJ	JJ	_	38	amod	_	_
36	natural	natural	JJ	JJ	_	38	amod	_	_
37	killer	killer	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	28	appos	_	_
39	.	.	.	.	_	26	punct	_	_

1	eGLs	egl	NNS	NNS	_	8	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	non-pregnant	non-pregnant	JJ	JJ	_	4	amod	_	_
4	endometrium	endometrium	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	early	early	JJ	JJ	_	7	amod	_	_
7	pregnancy	pregnancy	NN	NN	_	4	conj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	variable	variable	JJ	JJ	_	12	amod	_	_
11	proliferative	proliferative	JJ	JJ	_	12	amod	_	_
12	response	response	NN	NN	_	8	dobj	_	_
13	to	to	TO	TO	_	18	case	_	_
14	5	5	CD	CD	_	17	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	100	100	CD	CD	_	14	conj	_	_
17	U/ml	u/ml	NN	NN	_	18	dep	_	_
18	interleukin-2	interleukin-2	NN	NN	_	12	nmod	_	_
19	over	over	IN	IN	_	24	case	_	_
20	48-h	48-h	JJ	JJ	_	24	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	120-h	120-h	JJ	JJ	_	20	conj	_	_
23	time	time	NN	NN	_	24	compound	_	_
24	courses	course	NNS	NNS	_	8	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	eGLs	egl	NNS	NNS	_	5	nsubj	_	_
2	are	be	VBP	VBP	_	5	cop	_	_
3	evidently	evidently	RB	RB	_	5	advmod	_	_
4	functionally	functionally	RB	RB	_	5	advmod	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	eutopic	eutopic	JJ	JJ	_	9	amod	_	_
9	endometrium	endometrium	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Their	they	PRP$	PRP$	_	2	nmod:poss	_	_
2	absence	absence	NN	NN	_	20	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	endometriotic	endometriotic	JJ	JJ	_	5	amod	_	_
5	lesions	lesion	NNS	NNS	_	2	nmod	_	_
6	together	together	RB	RB	_	11	advmod	_	_
7	with	with	IN	IN	_	11	case	_	_
8	increased	increase	VBN	VBN	_	11	amod	_	_
9	CD+8	cd+8	JJ	JJ	_	11	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	numbers	number	NNS	NNS	_	2	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	increased	increase	VBN	VBN	_	15	amod	_	_
14	oestrogen	oestrogen	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	conj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	bcl-2	bcl-2	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	11	conj	_	_
19	may	may	MD	MD	_	20	aux	_	_
20	have	have	VB	VB	_	0	root	_	_
21	significant	significant	JJ	JJ	_	22	amod	_	_
22	effects	effect	NNS	NNS	_	20	dobj	_	_
23	on	on	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	development	development	NN	NN	_	20	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	progression	progression	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	endometriosis	endometriosis	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	interferon	interferon	NN	NN	_	7	dep	_	_
7	alpha-	alpha-	NN	NN	_	11	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	interferon	interferon	NN	NN	_	10	nmod:npmod	_	_
10	gamma-induced	gamma-induced	JJ	JJ	_	7	conj	_	_
11	genes	gene	NNS	NNS	_	3	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	suppressing	suppress	VBG	VBG	_	2	advcl	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	STAT1	stat1	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Interleukin-10	interleukin-10	NN	NN	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL-10	il-10	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	helps	help	VBZ	VBZ	_	0	root	_	_
6	maintain	maintain	VB	VB	_	5	ccomp	_	_
7	polarized	polarize	VBN	VBN	_	9	amod	_	_
8	T-helper	t-helper	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	18	case	_	_
11	a	a	DT	DT	_	18	det	_	_
12	T-helper	t-helper	NN	NN	_	18	compound	_	_
13	lymphocyte	lymphocyte	NN	NN	_	18	compound	_	_
14	2	2	CD	CD	_	18	nummod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	Th2	th2	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	phenotype	phenotype	NN	NN	_	6	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Part	part	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	process	process	NN	NN	_	1	nmod	_	_
5	involves	involve	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	prevention	prevention	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	development	development	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Th1	th1	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	19	nsubj	_	_
16	are	be	VBP	VBP	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	primary	primary	JJ	JJ	_	19	amod	_	_
19	source	source	NN	NN	_	13	acl:relcl	_	_
20	of	of	IN	IN	_	22	case	_	_
21	interferon	interferon	NN	NN	_	22	compound	_	_
22	gamma	gamma	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	IFNgamma	ifngamma	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	22	punct	_	_
27	a	a	DT	DT	_	29	det	_	_
28	potent	potent	JJ	JJ	_	29	amod	_	_
29	activator	activator	NN	NN	_	22	appos	_	_
30	of	of	IN	IN	_	31	case	_	_
31	monocytes	monocyte	NNS	NNS	_	29	nmod	_	_
32	and	and	CC	CC	_	29	cc	_	_
33	an	a	DT	DT	_	34	det	_	_
34	inhibitor	inhibitor	NN	NN	_	29	conj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	Th2	th2	NN	NN	_	37	compound	_	_
37	proliferation	proliferation	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	Because	because	IN	IN	_	7	mark	_	_
2	monocytes	monocyte	NNS	NNS	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	macrophages	macrophage	NNS	NNS	_	2	conj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	important	important	JJ	JJ	_	7	amod	_	_
7	mediators	mediator	NNS	NNS	_	18	advcl	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Th1-type	th1-type	JJ	JJ	_	10	amod	_	_
10	responses	response	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	such	such	JJ	JJ	_	15	case	_	_
13	as	as	IN	IN	_	12	mwe	_	_
14	delayed-type	delayed-type	JJ	JJ	_	15	amod	_	_
15	hypersensitivity	hypersensitivity	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	we	we	PRP	PRP	_	18	nsubj	_	_
18	sought	seek	VBD	VBD	_	0	root	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	determine	determine	VB	VB	_	18	xcomp	_	_
21	if	if	IN	IN	_	25	mark	_	_
22	IL-10	il-10	NN	NN	_	25	nsubj	_	_
23	could	could	MD	MD	_	25	aux	_	_
24	directly	directly	RB	RB	_	25	advmod	_	_
25	mediate	mediate	VB	VB	_	20	advcl	_	_
26	inhibition	inhibition	NN	NN	_	25	dobj	_	_
27	of	of	IN	IN	_	32	case	_	_
28	IFNgamma-	ifngamma-	NN	NN	_	32	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	IFNalpha-induced	ifnalpha-induced	JJ	JJ	_	28	conj	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	26	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	18	punct	_	_

1	Highly	highly	RB	RB	_	2	advmod	_	_
2	purified	purify	VBN	VBN	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	incubated	incubate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	IL-10	il-10	NN	NN	_	5	nmod	_	_
8	for	for	IN	IN	_	12	case	_	_
9	60	60	CD	CD	_	11	compound	_	_
10	to	to	TO	TO	_	11	dep	_	_
11	90	90	CD	CD	_	12	nummod	_	_
12	minutes	minute	NNS	NNS	_	5	nmod	_	_
13	before	before	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	addition	addition	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IFNgamma	ifngamma	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	IFNalpha	ifnalpha	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	IL-10	il-10	NN	NN	_	2	compound	_	_
2	preincubation	preincubation	NN	NN	_	3	nsubj	_	_
3	resulted	result	VBD	VBD	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	inhibition	inhibition	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	nmod	_	_
10	for	for	IN	IN	_	13	case	_	_
11	several	several	JJ	JJ	_	13	amod	_	_
12	IFN-induced	ifn-induced	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	such	such	JJ	JJ	_	17	case	_	_
16	as	as	IN	IN	_	15	mwe	_	_
17	IP-10	ip-10	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	ISG54	isg54	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	intercellular	intercellular	JJ	JJ	_	24	amod	_	_
23	adhesion	adhesion	NN	NN	_	24	compound	_	_
24	molecule-1	molecule-1	NN	NN	_	17	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	from	from	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ability	ability	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	IL-10	il-10	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	suppress	suppress	VB	VB	_	9	acl	_	_
14	IFN-induced	ifn-induced	JJ	JJ	_	15	amod	_	_
15	assembly	assembly	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	26	case	_	_
17	signal	signal	NN	NN	_	18	compound	_	_
18	transducer	transducer	NN	NN	_	26	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	activator	activator	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	transcription	transcription	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	STAT	stat	NN	NN	_	26	compound	_	_
25	)	)	-RRB-	-RRB-	_	26	punct	_	_
26	factors	factor	NNS	NNS	_	15	nmod	_	_
27	to	to	TO	TO	_	30	case	_	_
28	specific	specific	JJ	JJ	_	30	amod	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	motifs	motif	NNS	NNS	_	15	nmod	_	_
31	on	on	IN	IN	_	35	case	_	_
32	IFNalpha-	ifnalpha-	NN	NN	_	35	amod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	IFNgamma-inducible	ifngamma-inducible	JJ	JJ	_	32	conj	_	_
35	genes	gene	NNS	NNS	_	30	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	accomplished	accomplish	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	5	mark	_	_
5	preventing	prevent	VBG	VBG	_	3	advcl	_	_
6	the	the	DT	DT	_	9	det	_	_
7	IFN-induced	ifn-induced	JJ	JJ	_	9	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	STAT1	stat1	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	component	component	NN	NN	_	11	appos	_	_
15	of	of	IN	IN	_	22	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	IFNalpha-	ifnalpha-	NN	NN	_	22	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IFNgamma-induced	ifngamma-induced	JJ	JJ	_	17	conj	_	_
20	DNA	dna	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	complexes	complex	NNS	NNS	_	14	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Therefore	therefore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	IL-10	il-10	NN	NN	_	6	nsubj	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	directly	directly	RB	RB	_	6	advmod	_	_
6	inhibit	inhibit	VB	VB	_	0	root	_	_
7	STAT-dependent	stat-dependent	JJ	JJ	_	11	amod	_	_
8	early	early	JJ	JJ	_	11	amod	_	_
9	response	response	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	6	dobj	_	_
12	induced	induce	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	IFNalpha	ifnalpha	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IFNgamma	ifngamma	NN	NN	_	15	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	suppressing	suppress	VBG	VBG	_	6	advcl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	tyrosine	tyrosine	NN	NN	_	24	compound	_	_
24	phosphorylation	phosphorylation	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	STAT1	stat1	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	occur	occur	VB	VB	_	0	root	_	_
4	through	through	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ability	ability	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-10	il-10	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	induce	induce	VB	VB	_	6	acl	_	_
11	expression	expression	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	gene	gene	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	suppressor	suppressor	NN	NN	_	14	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	signaling	signaling	NN	NN	_	16	nmod	_	_
20	3	3	CD	CD	_	19	nummod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	SOCS3	socs3	NN	NN	_	16	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Megakaryocyte/Platelet-specific	megakaryocyte/platelet-specific	JJ	JJ	_	3	amod	_	_
3	enhancer	enhancer	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	alpha2beta1	alpha2beta1	NN	NN	_	8	compound	_	_
7	integrin	integrin	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	:	:	:	:	_	3	punct	_	_
10	two	two	CD	CD	_	13	nummod	_	_
11	tandem	tandem	JJ	JJ	_	13	amod	_	_
12	AP1	ap1	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	3	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	the	the	DT	DT	_	20	det	_	_
16	mitogen-activated	mitogen-activated	JJ	JJ	_	20	amod	_	_
17	protein	protein	NN	NN	_	20	compound	_	_
18	kinase	kinase	NN	NN	_	20	compound	_	_
19	signaling	signaling	NN	NN	_	20	compound	_	_
20	cascade	cascade	NN	NN	_	13	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	alpha2beta1	alpha2beta1	NN	NN	_	3	compound	_	_
3	integrin	integrin	NN	NN	_	14	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	collagen	collagen	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	3	appos	_	_
8	on	on	IN	IN	_	9	case	_	_
9	platelets	platelet	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	megakaryocytes	megakaryocyte	NNS	NNS	_	9	conj	_	_
12	,	,	,	,	_	3	punct	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	0	root	_	_
15	for	for	IN	IN	_	18	case	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	platelet	platelet	NN	NN	_	18	compound	_	_
18	function	function	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	alpha2	alpha2	NN	NN	_	7	compound	_	_
6	integrin	integrin	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	undergoing	undergo	VBG	VBG	_	9	acl	_	_
11	megakaryocytic	megakaryocytic	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	10	dobj	_	_
13	requires	require	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	core	core	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	13	dobj	_	_
17	between	between	IN	IN	_	18	case	_	_
18	bp	bp	NN	NN	_	16	nmod	_	_
19	-30	-30	CD	CD	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	-92	-92	CD	CD	_	19	conj	_	_
22	,	,	,	,	_	16	punct	_	_
23	a	a	DT	DT	_	24	det	_	_
24	silencer	silencer	NN	NN	_	16	conj	_	_
25	between	between	IN	IN	_	26	case	_	_
26	bp	bp	NN	NN	_	24	nmod	_	_
27	-92	-92	CD	CD	_	26	dep	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	-351	-351	CD	CD	_	27	conj	_	_
30	,	,	,	,	_	16	punct	_	_
31	and	and	CC	CC	_	16	cc	_	_
32	megakaryocytic	megakaryocytic	JJ	JJ	_	33	amod	_	_
33	enhancers	enhancer	NNS	NNS	_	16	conj	_	_
34	in	in	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	distal	distal	JJ	JJ	_	38	amod	_	_
37	5'	5'	JJ	JJ	_	38	amod	_	_
38	flank	flank	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	229-bp	229-bp	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	distal	distal	JJ	JJ	_	12	amod	_	_
11	5'	5'	JJ	JJ	_	12	amod	_	_
12	flank	flank	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	alpha2	alpha2	CD	CD	_	17	nummod	_	_
16	integrin	integrin	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	12	nmod	_	_
18	required	require	VBN	VBN	_	7	acl	_	_
19	for	for	IN	IN	_	24	case	_	_
20	high-level	high-level	JJ	JJ	_	24	amod	_	_
21	enhancer	enhancer	NN	NN	_	24	compound	_	_
22	activity	activity	NN	NN	_	24	compound	_	_
23	in	in	IN	IN	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	18	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	megakaryocytic	megakaryocytic	JJ	JJ	_	27	amod	_	_
27	features	feature	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Two	two	CD	CD	_	5	nummod	_	_
2	tandem	tandem	JJ	JJ	_	5	amod	_	_
3	AP1	ap1	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	10	nsubjpass	_	_
6	with	with	IN	IN	_	8	case	_	_
7	dyad	dyad	NN	NN	_	8	compound	_	_
8	symmetry	symmetry	NN	NN	_	5	nmod	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	13	case	_	_
12	enhancer	enhancer	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	for	for	IN	IN	_	18	case	_	_
16	DNA-protein	dna-protein	JJ	JJ	_	18	amod	_	_
17	complex	complex	NN	NN	_	18	compound	_	_
18	formation	formation	NN	NN	_	13	conj	_	_
19	with	with	IN	IN	_	20	case	_	_
20	members	member	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	c-fos/c-jun	c-fos/c-jun	NN	NN	_	24	compound	_	_
24	family	family	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	requirement	requirement	NN	NN	_	6	nsubj	_	_
3	for	for	IN	IN	_	5	case	_	_
4	AP1	ap1	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	for	for	IN	IN	_	18	case	_	_
10	the	the	DT	DT	_	18	det	_	_
11	mitogen-activated	mitogen-activated	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MAPK	mapk	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	8	nmod	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	regulating	regulate	VBG	VBG	_	8	acl	_	_
21	alpha2	alpha2	NN	NN	_	24	compound	_	_
22	integrin	integrin	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	20	dobj	_	_
25	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	18	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	MAP	map	NN	NN	_	6	compound	_	_
5	kinase	kinase	NN	NN	_	6	compound	_	_
6	cascade	cascade	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	PD98059	pd98059	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	12	det	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	inhibitor	inhibitor	NN	NN	_	8	appos	_	_
13	of	of	IN	IN	_	15	case	_	_
14	MAPK	mapk	NN	NN	_	15	compound	_	_
15	kinase	kinase	NN	NN	_	12	nmod	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	,	,	,	,	_	8	punct	_	_
18	prevented	prevent	VBD	VBD	_	0	root	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	alpha2	alpha2	NN	NN	_	25	compound	_	_
24	integrin	integrin	NN	NN	_	25	compound	_	_
25	subunit	subunit	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	cells	cell	NNS	NNS	_	20	nmod	_	_
28	induced	induce	VBN	VBN	_	27	acl	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	become	become	VB	VB	_	28	xcomp	_	_
31	megakaryocytic	megakaryocytic	JJ	JJ	_	30	xcomp	_	_
32	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	megakaryocytic	megakaryocytic	JJ	JJ	_	7	amod	_	_
7	differentiation	differentiation	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	which	which	WDT	WDT	_	16	nmod	_	_
10	expression	expression	NN	NN	_	16	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	alpha2	alpha2	NN	NN	_	15	compound	_	_
14	integrin	integrin	NN	NN	_	15	compound	_	_
15	gene	gene	NN	NN	_	10	nmod	_	_
16	requires	require	VBZ	VBZ	_	4	acl:relcl	_	_
17	signaling	signal	VBG	VBG	_	16	dobj	_	_
18	via	via	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	MAP	map	NN	NN	_	22	compound	_	_
21	kinase	kinase	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	17	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	activate	activate	VB	VB	_	16	xcomp	_	_
25	two	two	CD	CD	_	29	nummod	_	_
26	tandem	tandem	JJ	JJ	_	29	amod	_	_
27	AP1	ap1	NN	NN	_	29	compound	_	_
28	binding	binding	NN	NN	_	29	compound	_	_
29	sites	site	NNS	NNS	_	24	dobj	_	_
30	in	in	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	alpha2	alpha2	NN	NN	_	34	compound	_	_
33	integrin	integrin	NN	NN	_	34	compound	_	_
34	enhancer	enhancer	NN	NN	_	24	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	Clonality	clonality	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	isolated	isolate	VBN	VBN	_	4	amod	_	_
4	eosinophils	eosinophil	NNS	NNS	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	hypereosinophilic	hypereosinophilic	JJ	JJ	_	8	amod	_	_
8	syndrome	syndrome	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	idiopathic	idiopathic	JJ	JJ	_	4	amod	_	_
3	hypereosinophilic	hypereosinophilic	JJ	JJ	_	4	amod	_	_
4	syndrome	syndrome	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IHES	ihes	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	rare	rare	JJ	JJ	_	11	amod	_	_
11	disorder	disorder	NN	NN	_	0	root	_	_
12	characterized	characterize	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	17	case	_	_
14	unexplained	unexplained	JJ	JJ	_	17	amod	_	_
15	,	,	,	,	_	14	punct	_	_
16	persistent	persistent	JJ	JJ	_	14	dep	_	_
17	eosinophilia	eosinophilia	NN	NN	_	12	nmod	_	_
18	associated	associate	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	22	case	_	_
20	multiple	multiple	JJ	JJ	_	22	amod	_	_
21	organ	organ	NN	NN	_	22	compound	_	_
22	dysfunction	dysfunction	NN	NN	_	18	nmod	_	_
23	due	due	JJ	JJ	_	27	case	_	_
24	to	to	TO	TO	_	23	mwe	_	_
25	eosinophilic	eosinophilic	JJ	JJ	_	27	amod	_	_
26	tissue	tissue	NN	NN	_	27	compound	_	_
27	infiltration	infiltration	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	dep	_	_
3	absence	absence	NN	NN	_	6	dep	_	_
4	of	of	IN	IN	_	6	case	_	_
5	karyotypic	karyotypic	JJ	JJ	_	6	amod	_	_
6	abnormalities	abnormality	NNS	NNS	_	9	nmod	_	_
7	,	,	,	,	_	9	punct	_	_
8	there	there	EX	EX	_	9	expl	_	_
9	is	be	VBZ	VBZ	_	0	root	_	_
10	no	no	DT	DT	_	12	neg	_	_
11	specific	specific	JJ	JJ	_	12	amod	_	_
12	test	test	NN	NN	_	9	nsubj	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	detect	detect	VB	VB	_	12	acl	_	_
15	clonal	clonal	JJ	JJ	_	16	amod	_	_
16	eosinophilia	eosinophilia	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	18	case	_	_
18	IHES	ihes	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	X-chromosome	x-chromosome	NN	NN	_	5	compound	_	_
4	inactivation	inactivation	NN	NN	_	5	compound	_	_
5	patterns	pattern	NNS	NNS	_	1	nmod	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	determine	determine	VB	VB	_	8	xcomp	_	_
11	whether	whether	IN	IN	_	15	mark	_	_
12	proliferative	proliferative	JJ	JJ	_	13	amod	_	_
13	disorders	disorder	NNS	NNS	_	15	nsubj	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	clonal	clonal	JJ	JJ	_	10	ccomp	_	_
16	in	in	IN	IN	_	17	case	_	_
17	origin	origin	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Methylation	methylation	NN	NN	_	24	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	HpaII	hpaii	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Hha	hha	NN	NN	_	3	conj	_	_
6	I	i	CD	CD	_	7	nummod	_	_
7	sites	site	NNS	NNS	_	1	nmod	_	_
8	near	near	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	polymorphic	polymorphic	JJ	JJ	_	12	amod	_	_
11	trinucleotide	trinucleotide	NN	NN	_	12	compound	_	_
12	repeat	repeat	NN	NN	_	1	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	androgen	androgen	NN	NN	_	18	compound	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HUMARA	humara	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	shown	show	VBN	VBN	_	0	root	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	correlate	correlate	VB	VB	_	24	xcomp	_	_
27	with	with	IN	IN	_	28	case	_	_
28	X-inactivation	x-inactivation	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	polymerase	polymerase	NN	NN	_	11	compound	_	_
10	chain	chain	NN	NN	_	11	compound	_	_
11	reaction	reaction	NN	NN	_	7	dobj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PCR	pcr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	with	with	IN	IN	_	17	case	_	_
16	nested	nested	JJ	JJ	_	17	amod	_	_
17	primers	primer	NNS	NNS	_	11	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	analyze	analyze	VB	VB	_	7	advcl	_	_
20	X-inactivation	x-inactivation	JJ	JJ	_	21	amod	_	_
21	patterns	pattern	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	HUMARA	humara	NN	NN	_	25	compound	_	_
25	loci	locus	NNS	NNS	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	purified	purify	VBN	VBN	_	28	amod	_	_
28	eosinophils	eosinophil	NNS	NNS	_	25	nmod	_	_
29	from	from	IN	IN	_	31	case	_	_
30	female	female	JJ	JJ	_	31	amod	_	_
31	patients	patient	NNS	NNS	_	28	nmod	_	_
32	with	with	IN	IN	_	33	case	_	_
33	eosinophilia	eosinophilia	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	eosinophils	eosinophil	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	isolated	isolate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
8	autofluoresence	autofluoresence	NN	NN	_	5	nmod	_	_
9	using	use	VBG	VBG	_	5	xcomp	_	_
10	flow	flow	NN	NN	_	12	compound	_	_
11	cytometric	cytometric	JJ	JJ	_	12	amod	_	_
12	sorting	sorting	NN	NN	_	9	dobj	_	_
13	.	.	.	.	_	5	punct	_	_

1	Eosinophils	eosinophil	NNS	NNS	_	11	nsubjpass	_	_
2	purified	purify	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	female	female	JJ	JJ	_	6	amod	_	_
6	patient	patient	NN	NN	_	2	nmod	_	_
7	presenting	present	VBG	VBG	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	IHES	ihes	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	show	show	VB	VB	_	11	xcomp	_	_
14	a	a	DT	DT	_	16	det	_	_
15	clonal	clonal	JJ	JJ	_	16	amod	_	_
16	pattern	pattern	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	X-inactivation	x-inactivation	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	Eosinophil-depleted	eosinophil-depleted	JJ	JJ	_	2	amod	_	_
2	leukocytes	leukocyte	NNS	NNS	_	7	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	patient	patient	NN	NN	_	2	nmod	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	polyclonal	polyclonal	JJ	JJ	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	HUMARA	humara	NN	NN	_	10	compound	_	_
10	analysis	analysis	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	7	punct	_	_
12	thus	thus	RB	RB	_	13	advmod	_	_
13	excluding	exclude	VBG	VBG	_	7	xcomp	_	_
14	skewedness	skewedness	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	random	random	JJ	JJ	_	17	amod	_	_
17	X-inactivation	x-inactivation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	corticosteroid	corticosteroid	NN	NN	_	3	compound	_	_
3	suppression	suppression	NN	NN	_	18	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	her	she	PRP$	PRP$	_	7	nmod:poss	_	_
6	blood	blood	NN	NN	_	7	compound	_	_
7	eosinophilia	eosinophilia	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	18	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	clonal	clonal	JJ	JJ	_	11	amod	_	_
11	population	population	NN	NN	_	18	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	eosinophils	eosinophil	NNS	NNS	_	11	nmod	_	_
14	could	could	MD	MD	_	18	aux	_	_
15	no	no	RB	RB	_	16	neg	_	_
16	longer	longer	RB	RB	_	18	advmod	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	detected	detect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	purified	purified	JJ	JJ	_	21	amod	_	_
21	eosinophils	eosinophil	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	29	nmod	_	_
3	,	,	,	,	_	29	punct	_	_
4	eosinophils	eosinophil	NNS	NNS	_	29	nsubj	_	_
5	purified	purify	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	patient	patient	NN	NN	_	5	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	Churg-Strauss	churg-strauss	JJ	JJ	_	11	amod	_	_
11	syndrome	syndrome	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	from	from	IN	IN	_	15	case	_	_
14	six	six	CD	CD	_	15	nummod	_	_
15	patients	patient	NNS	NNS	_	8	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	reactive	reactive	JJ	JJ	_	18	amod	_	_
18	eosinophilias	eosinophilia	NNS	NNS	_	15	nmod	_	_
19	attributed	attribute	VBN	VBN	_	18	acl	_	_
20	to	to	TO	TO	_	21	case	_	_
21	allergy	allergy	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	parasitic	parasitic	JJ	JJ	_	24	amod	_	_
24	infection	infection	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	or	or	CC	CC	_	21	cc	_	_
27	drug	drug	NN	NN	_	28	compound	_	_
28	reaction	reaction	NN	NN	_	21	conj	_	_
29	showed	show	VBD	VBD	_	0	root	_	_
30	a	a	DT	DT	_	32	det	_	_
31	polyclonal	polyclonal	JJ	JJ	_	32	amod	_	_
32	pattern	pattern	NN	NN	_	29	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	X-inactivation	x-inactivation	NN	NN	_	32	nmod	_	_
35	by	by	IN	IN	_	37	case	_	_
36	HUMARA	humara	NN	NN	_	37	compound	_	_
37	analysis	analysis	NN	NN	_	29	nmod	_	_
38	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	clonal	clonal	JJ	JJ	_	5	amod	_	_
5	eosinophilia	eosinophilia	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	patient	patient	NN	NN	_	2	nmod	_	_
9	presenting	present	VBG	VBG	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	IHES	ihes	NN	NN	_	9	nmod	_	_
12	indicates	indicate	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	such	such	JJ	JJ	_	15	amod	_	_
15	patients	patient	NNS	NNS	_	17	nsubj	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	have	have	VB	VB	_	12	ccomp	_	_
18	,	,	,	,	_	17	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	reality	reality	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	a	a	DT	DT	_	25	det	_	_
23	low-grade	low-grade	JJ	JJ	_	25	amod	_	_
24	clonal	clonal	JJ	JJ	_	25	amod	_	_
25	disorder	disorder	NN	NN	_	17	dobj	_	_
26	that	that	WDT	WDT	_	29	nsubjpass	_	_
27	can	can	MD	MD	_	29	aux	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	distinguished	distinguish	VBN	VBN	_	25	acl:relcl	_	_
30	from	from	IN	IN	_	32	case	_	_
31	reactive	reactive	JJ	JJ	_	32	amod	_	_
32	eosinophilias	eosinophilia	NNS	NNS	_	29	nmod	_	_
33	by	by	IN	IN	_	35	case	_	_
34	HUMARA	humara	NN	NN	_	35	compound	_	_
35	analysis	analysis	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	12	punct	_	_

1	Further	further	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	method	method	NN	NN	_	8	nsubjpass	_	_
5	described	describe	VBN	VBN	_	4	acl	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	monitor	monitor	VB	VB	_	8	xcomp	_	_
11	disease	disease	NN	NN	_	12	compound	_	_
12	progression	progression	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CTCF	ctcf	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	11	det	_	_
9	c-myc	c-myc	NN	NN	_	11	compound	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	6	appos	_	_
12	,	,	,	,	_	6	punct	_	_
13	during	during	IN	IN	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	2	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	CTCF	ctcf	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	repressor	repressor	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	c-myc	c-myc	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	CTCF	ctcf	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	characterized	characterize	VBN	VBN	_	11	advcl	_	_
6	in	in	IN	IN	_	8	case	_	_
7	some	some	DT	DT	_	8	det	_	_
8	detail	detail	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	there	there	EX	EX	_	11	expl	_	_
11	is	be	VBZ	VBZ	_	0	root	_	_
12	very	very	RB	RB	_	13	advmod	_	_
13	little	little	JJ	JJ	_	14	amod	_	_
14	information	information	NN	NN	_	11	nsubj	_	_
15	about	about	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regulation	regulation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	CTCF	ctcf	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	CTCF	ctcf	NN	NN	_	3	dobj	_	_
5	expression	expression	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	phosphorylation	phosphorylation	NN	NN	_	5	conj	_	_
8	during	during	IN	IN	_	10	case	_	_
9	induced	induce	VBN	VBN	_	10	amod	_	_
10	differentiation	differentiation	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
14	leukemia	leukemia	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	:	:	:	:	_	14	punct	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	i	i	LS	LS	_	14	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	CTCF	ctcf	NN	NN	_	14	nsubjpass	_	_
10	mRNA	mrna	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	protein	protein	NN	NN	_	10	conj	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	down-regulated	down-regulate	VBN	VBN	_	2	ccomp	_	_
15	during	during	IN	IN	_	17	case	_	_
16	terminal	terminal	JJ	JJ	_	17	amod	_	_
17	differentiation	differentiation	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	most	most	JJS	JJS	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	14	nmod	_	_
22	tested	test	VBN	VBN	_	21	acl	_	_
23	;	;	:	:	_	14	punct	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	ii	ii	LS	LS	_	30	dep	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	CTCF	ctcf	NN	NN	_	28	compound	_	_
28	down-regulation	down-regulation	NN	NN	_	30	nsubjpass	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	retarded	retard	VBN	VBN	_	14	parataxis	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	less	less	RBR	RBR	_	33	advmod	_	_
33	pronounced	pronounced	JJ	JJ	_	30	conj	_	_
34	than	than	IN	IN	_	35	case	_	_
35	that	that	DT	DT	_	33	nmod	_	_
36	of	of	IN	IN	_	37	case	_	_
37	c-myc	c-myc	NN	NN	_	35	nmod	_	_
38	;	;	:	:	_	14	punct	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	iii	iii	LS	LS	_	46	dep	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	CTCF	ctcf	NN	NN	_	43	compound	_	_
43	protein	protein	NN	NN	_	46	nsubjpass	_	_
44	is	be	VBZ	VBZ	_	46	auxpass	_	_
45	differentially	differentially	RB	RB	_	46	advmod	_	_
46	phosphorylated	phosphorylate	VBN	VBN	_	14	parataxis	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	the	the	DT	DT	_	50	det	_	_
49	phosphorylation	phosphorylation	NN	NN	_	50	compound	_	_
50	profiles	profile	NNS	NNS	_	51	nsubj	_	_
51	depend	depend	VBP	VBP	_	46	conj	_	_
52	on	on	IN	IN	_	55	case	_	_
53	the	the	DT	DT	_	55	det	_	_
54	differentiation	differentiation	NN	NN	_	55	compound	_	_
55	pathway	pathway	NN	NN	_	51	nmod	_	_
56	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	concluded	conclude	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	CTCF	ctcf	NN	NN	_	9	nsubjpass	_	_
5	expression	expression	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	activity	activity	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	controlled	control	VBN	VBN	_	2	ccomp	_	_
10	at	at	IN	IN	_	14	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	post-transcriptional	post-transcriptional	JJ	JJ	_	11	conj	_	_
14	levels	level	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	T-cell	t-cell	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	GATA-3	gata-3	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	non-lineage-specific	non-lineage-specific	JJ	JJ	_	13	amod	_	_
13	silencer	silencer	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GATA-3	gata-3	NN	NN	_	4	compound	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	required	require	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	development	development	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	T-cell	t-cell	NN	NN	_	12	compound	_	_
12	lineage	lineage	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	Th2	th2	NN	NN	_	17	compound	_	_
15	cytokine	cytokine	NN	NN	_	17	compound	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	8	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	CD4	cd4	NN	NN	_	20	compound	_	_
20	T-cells	t-cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	mapped	map	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	9	det	_	_
5	DNase-I-hypersensitive	dnase-i-hypersensitive	JJ	JJ	_	9	amod	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	HS	hs	JJ	JJ	_	9	amod	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	regions	region	NNS	NNS	_	3	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	GATA-3	gata-3	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	9	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	T-cells	t-cell	NNS	NNS	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	non-T-cells	non-t-cell	NNS	NNS	_	16	conj	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	studied	study	VBD	VBD	_	3	conj	_	_
21	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activities	activity	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	HS	hs	NN	NN	_	13	nsubjpass	_	_
2	I-III	i-iii	CD	CD	_	1	nummod	_	_
3	,	,	,	,	_	1	punct	_	_
4	located	located	JJ	JJ	_	1	amod	_	_
5	5'	5'	RB	RB	_	4	nmod	_	_
6	from	from	IN	IN	_	5	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
9	initiation	initiation	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	dep	_	_
11	,	,	,	,	_	1	punct	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	non-hematopoietic	non-hematopoietic	JJ	JJ	_	15	conj	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	whereas	whereas	IN	IN	_	13	dep	_	_
21	HS	hs	NN	NN	_	34	nsubjpass	_	_
22	IV-VII	iv-vii	CD	CD	_	21	nummod	_	_
23	,	,	,	,	_	21	punct	_	_
24	located	located	JJ	JJ	_	21	amod	_	_
25	3'	3'	RB	RB	_	24	nmod	_	_
26	from	from	IN	IN	_	25	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
29	start	start	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	25	dep	_	_
31	,	,	,	,	_	21	punct	_	_
32	were	be	VBD	VBD	_	34	auxpass	_	_
33	exclusively	exclusively	RB	RB	_	34	advmod	_	_
34	observed	observe	VBN	VBN	_	13	parataxis	_	_
35	in	in	IN	IN	_	36	case	_	_
36	T-cells	t-cell	NNS	NNS	_	34	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	Among	among	IN	IN	_	4	case	_	_
2	these	these	DT	DT	_	4	det	_	_
3	hypersensitive	hypersensitive	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
8	control	control	NN	NN	_	9	compound	_	_
9	elements	element	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	one	one	CD	CD	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	first	first	JJ	JJ	_	17	amod	_	_
17	intron	intron	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	GATA-3	gata-3	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	17	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	the	the	DT	DT	_	24	det	_	_
24	other	other	JJ	JJ	_	13	conj	_	_
25	between	between	IN	IN	_	29	case	_	_
26	8.3	8.3	CD	CD	_	29	nummod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	5.9	5.9	CD	CD	_	26	conj	_	_
29	kilobases	kilobase	NNS	NNS	_	24	nmod	_	_
30	5'	5'	JJ	JJ	_	29	nmod	_	_
31	from	from	IN	IN	_	30	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	GATA-3	gata-3	NN	NN	_	36	compound	_	_
34	transcriptional	transcriptional	JJ	JJ	_	36	amod	_	_
35	initiation	initiation	NN	NN	_	36	compound	_	_
36	site	site	NN	NN	_	30	dep	_	_
37	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	intron	intron	NN	NN	_	4	nsubj	_	_
4	acted	act	VBD	VBD	_	0	root	_	_
5	as	as	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	strong	strong	JJ	JJ	_	9	amod	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activator	activator	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	position-dependent	position-dependent	JJ	JJ	_	13	amod	_	_
13	manner	manner	NN	NN	_	4	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	with	with	IN	IN	_	18	case	_	_
16	no	no	DT	DT	_	18	neg	_	_
17	cell-type	cell-type	JJ	JJ	_	18	amod	_	_
18	specificity	specificity	NN	NN	_	13	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	upstream	upstream	JJ	JJ	_	4	amod	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	6	nsubj	_	_
5	could	could	MD	MD	_	6	aux	_	_
6	confer	confer	VB	VB	_	0	root	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	specificity	specificity	NN	NN	_	6	dobj	_	_
9	to	to	TO	TO	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	GATA-3	gata-3	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	analysis	analysis	NN	NN	_	20	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	region	region	NN	NN	_	16	nmod	_	_
20	revealed	reveal	VBD	VBD	_	6	conj	_	_
21	a	a	DT	DT	_	24	det	_	_
22	707-base	707-base	JJ	JJ	_	24	amod	_	_
23	pair	pair	NN	NN	_	24	compound	_	_
24	silencer	silencer	NN	NN	_	20	dobj	_	_
25	that	that	WDT	WDT	_	27	nsubj	_	_
26	drastically	drastically	RB	RB	_	27	advmod	_	_
27	inhibited	inhibit	VBD	VBD	_	24	acl:relcl	_	_
28	GATA-3	gata-3	NN	NN	_	30	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	32	case	_	_
32	non-T-cells	non-t-cell	NNS	NNS	_	30	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	CAGGTG	caggtg	NN	NN	_	3	compound	_	_
3	E-boxes	e-box	NNS	NNS	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	located	located	JJ	JJ	_	3	amod	_	_
6	at	at	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	5'-	5'-	JJ	JJ	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	3'-ends	3'-end	NNS	NNS	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	silencer	silencer	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	were	be	VBD	VBD	_	16	cop	_	_
16	necessary	necessary	JJ	JJ	_	0	root	_	_
17	for	for	IN	IN	_	20	case	_	_
18	this	this	DT	DT	_	20	det	_	_
19	silencer	silencer	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	3'-CAGGTG	3'-caggtg	NN	NN	_	3	compound	_	_
3	E-box	e-box	NN	NN	_	5	nsubj	_	_
4	could	could	MD	MD	_	5	aux	_	_
5	bind	bind	VB	VB	_	0	root	_	_
6	USF	usf	NN	NN	_	7	compound	_	_
7	proteins	protein	NNS	NNS	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	the	the	DT	DT	_	12	det	_	_
10	ubiquitous	ubiquitous	JJ	JJ	_	12	amod	_	_
11	repressor	repressor	NN	NN	_	12	compound	_	_
12	ZEB	zeb	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	7	punct	_	_
14	or	or	CC	CC	_	7	cc	_	_
15	the	the	DT	DT	_	18	det	_	_
16	basic	basic	JJ	JJ	_	18	amod	_	_
17	helix-loop-helix	helix-loop-helix	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	7	conj	_	_
19	E2A	e2a	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	HEB	heb	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	5	punct	_	_
23	and	and	CC	CC	_	5	cc	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	showed	show	VBD	VBD	_	5	conj	_	_
26	that	that	IN	IN	_	35	mark	_	_
27	a	a	DT	DT	_	28	det	_	_
28	competition	competition	NN	NN	_	35	nsubjpass	_	_
29	between	between	IN	IN	_	30	case	_	_
30	ZEB	zeb	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	E2A/HEB	e2a/heb	NN	NN	_	33	compound	_	_
33	proteins	protein	NNS	NNS	_	30	conj	_	_
34	is	be	VBZ	VBZ	_	35	auxpass	_	_
35	involved	involve	VBN	VBN	_	25	ccomp	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	silencer	silencer	NN	NN	_	39	compound	_	_
39	activity	activity	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	Clonality	clonality	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	refractory	refractory	JJ	JJ	_	5	amod	_	_
5	anemia	anemia	NN	NN	_	2	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	ring	ring	NN	NN	_	8	compound	_	_
8	sideroblasts	sideroblast	NNS	NNS	_	5	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	simultaneous	simultaneous	JJ	JJ	_	11	amod	_	_
11	study	study	NN	NN	_	2	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	clonality	clonality	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cytochemistry	cytochemistry	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	bone	bone	NN	NN	_	19	compound	_	_
18	marrow	marrow	NN	NN	_	19	compound	_	_
19	progenitors	progenitor	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	X	x	NN	NN	_	3	compound	_	_
2	chromosome	chromosome	NN	NN	_	3	compound	_	_
3	inactivation	inactivation	NN	NN	_	17	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	polymorphism	polymorphism	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	14	case	_	_
7	the	the	DT	DT	_	14	det	_	_
8	human	human	JJ	JJ	_	14	amod	_	_
9	androgen	androgen	NN	NN	_	14	compound	_	_
10	receptor	receptor	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	HUMARA	humara	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	gene	gene	NN	NN	_	3	nmod	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	applied	apply	VBN	VBN	_	0	root	_	_
18	for	for	IN	IN	_	19	mark	_	_
19	analyzing	analyze	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	clonality	clonality	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	blood	blood	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	clonal	clonal	JJ	JJ	_	8	amod	_	_
8	relationship	relationship	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	investigated	investigate	VBN	VBN	_	0	root	_	_
11	between	between	IN	IN	_	15	case	_	_
12	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	polymorphonuclear	polymorphonuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PMNCs	pmnc	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	marrow	marrow	JJ	JJ	_	22	amod	_	_
21	progenitor	progenitor	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	conj	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	the	the	DT	DT	_	25	det	_	_
25	origin	origin	NN	NN	_	15	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	ringed	ringed	JJ	JJ	_	28	amod	_	_
28	sideroblasts	sideroblast	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	30	case	_	_
30	patients	patient	NNS	NNS	_	28	nmod	_	_
31	with	with	IN	IN	_	33	case	_	_
32	refractory	refractory	JJ	JJ	_	33	amod	_	_
33	anemia	anemia	NN	NN	_	30	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	ring	ring	NN	NN	_	36	compound	_	_
36	sideroblasts	sideroblast	NNS	NNS	_	33	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	RARS	rars	NN	NN	_	33	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	by	by	IN	IN	_	43	case	_	_
41	polymerase	polymerase	NN	NN	_	43	compound	_	_
42	chain	chain	NN	NN	_	43	compound	_	_
43	reaction	reaction	NN	NN	_	10	nmod	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	PCR	pcr	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	of	of	IN	IN	_	49	case	_	_
48	HUMARA	humara	NN	NN	_	49	compound	_	_
49	gene	gene	NN	NN	_	43	nmod	_	_
50	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	X-inactivation	x-inactivation	NN	NN	_	3	compound	_	_
3	patterns	pattern	NNS	NNS	_	24	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	circulating	circulate	VBG	VBG	_	6	amod	_	_
6	PMNCs	pmnc	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	6	conj	_	_
10	as	as	RB	RB	_	6	cc	_	_
11	well	well	RB	RB	_	10	mwe	_	_
12	as	as	IN	IN	_	10	mwe	_	_
13	individual	individual	JJ	JJ	_	15	amod	_	_
14	granulocyte	granulocyte	NN	NN	_	15	compound	_	_
15	colonies	colony	NNS	NNS	_	6	conj	_	_
16	grown	grow	VBN	VBN	_	15	acl	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	16	advmod	_	_
19	from	from	IN	IN	_	22	case	_	_
20	bone	bone	NN	NN	_	22	compound	_	_
21	marrow	marrow	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	6	nmod	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	analyzed	analyze	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	development	development	NN	NN	_	18	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	ringed	ringed	JJ	JJ	_	5	amod	_	_
5	sideroblasts	sideroblast	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
8	colonies	colony	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	iron	iron	NN	NN	_	11	compound	_	_
11	staining	staining	NN	NN	_	2	nmod	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
14	X-inactivation	x-inactivation	NN	NN	_	15	compound	_	_
15	pattern	pattern	NN	NN	_	2	conj	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	also	also	RB	RB	_	18	advmod	_	_
18	examined	examine	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	All	all	DT	DT	_	4	det	_	_
2	three	three	CD	CD	_	4	nummod	_	_
3	RARS	rar	NNS	NNS	_	4	compound	_	_
4	patients	patient	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	PMNCs	pmnc	NNS	NNS	_	5	dobj	_	_
8	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	granulocyte	granulocyte	NN	NN	_	3	compound	_	_
3	colonies	colony	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	however	however	RB	RB	_	12	advmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	two	two	CD	CD	_	10	nummod	_	_
8	different	different	JJ	JJ	_	10	amod	_	_
9	X-inactivation	x-inactivation	NN	NN	_	10	compound	_	_
10	patterns	pattern	NNS	NNS	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	all	all	DT	DT	_	15	det	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	indicating	indicate	VBG	VBG	_	12	xcomp	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	non-clonal	non-clonal	JJ	JJ	_	21	amod	_	_
20	progenitor	progenitor	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	22	nsubj	_	_
22	remained	remain	VBD	VBD	_	17	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	bone	bone	NN	NN	_	26	compound	_	_
26	marrow	marrow	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	erythroid	erythroid	JJ	JJ	_	3	amod	_	_
3	colonies	colony	NNS	NNS	_	9	nsubj	_	_
4	consisted	consist	VBN	VBN	_	3	acl	_	_
5	of	of	IN	IN	_	7	case	_	_
6	ringed	ringed	JJ	JJ	_	7	amod	_	_
7	sideroblasts	sideroblast	NNS	NNS	_	4	nmod	_	_
8	exclusively	exclusively	RB	RB	_	9	advmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	one	one	CD	CD	_	11	nummod	_	_
11	pattern	pattern	NN	NN	_	9	dobj	_	_
12	dominant	dominant	JJ	JJ	_	11	amod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	PMNCs	pmnc	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	non-clonal	non-clonal	JJ	JJ	_	7	amod	_	_
6	progenitor	progenitor	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	persist	persist	VBP	VBP	_	3	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	some	some	DT	DT	_	12	det	_	_
11	RARS	rars	NN	NN	_	12	compound	_	_
12	cases	case	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	that	that	IN	IN	_	17	mark	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	progenitors	progenitor	NNS	NNS	_	17	nsubj	_	_
17	show	show	VBP	VBP	_	8	conj	_	_
18	mosaicism	mosaicism	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	8	punct	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	ringed	ringed	JJ	JJ	_	23	amod	_	_
23	sideroblasts	sideroblast	NNS	NNS	_	26	nsubjpass	_	_
24	may	may	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	derived	derive	VBN	VBN	_	8	conj	_	_
27	from	from	IN	IN	_	30	case	_	_
28	an	a	DT	DT	_	30	det	_	_
29	abnormal	abnormal	JJ	JJ	_	30	amod	_	_
30	clone	clone	NN	NN	_	26	nmod	_	_
31	involved	involve	VBN	VBN	_	30	acl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	pathogenesis	pathogenesis	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	this	this	DT	DT	_	37	det	_	_
37	disease	disease	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-Rel	c-rel	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	7	case	_	_
5	STAT5	stat5	NN	NN	_	7	compound	_	_
6	target	target	NN	NN	_	7	compound	_	_
7	sequences	sequence	NNS	NNS	_	1	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	type	type	NN	NN	_	7	compound	_	_
3	I	i	CD	CD	_	7	nummod	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	T-cell	t-cell	NN	NN	_	7	compound	_	_
6	leukemia	leukemia	NN	NN	_	7	compound	_	_
7	virus	virus	NN	NN	_	11	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HTLV-I	htlv-i	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	abnormal	abnormal	JJ	JJ	_	13	amod	_	_
13	growth	growth	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	subsequent	subsequent	JJ	JJ	_	16	amod	_	_
16	transformation	transformation	NN	NN	_	13	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	associated	associate	VBN	VBN	_	13	acl:relcl	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	development	development	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	31	case	_	_
28	an	a	DT	DT	_	31	det	_	_
29	acute	acute	JJ	JJ	_	31	amod	_	_
30	T-cell	t-cell	NN	NN	_	31	compound	_	_
31	malignancy	malignancy	NN	NN	_	26	nmod	_	_
32	termed	term	VBD	VBD	_	31	acl	_	_
33	adult	adult	JJ	JJ	_	35	amod	_	_
34	T-cell	t-cell	NN	NN	_	35	compound	_	_
35	leukemia	leukemia	NN	NN	_	32	xcomp	_	_
36	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	characteristic	characteristic	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	the	the	DT	DT	_	11	det	_	_
9	constitutive	constitutive	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factors	factor	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	appears	appear	VBZ	VBZ	_	11	acl:relcl	_	_
21	to	to	TO	TO	_	23	mark	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	essential	essential	JJ	JJ	_	20	xcomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	growth	growth	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	these	these	DT	DT	_	30	det	_	_
29	transformed	transform	VBN	VBN	_	30	amod	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	11	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	22	advcl	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	induce	induce	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	T-cell	t-cell	NN	NN	_	16	compound	_	_
12	growth	growth	NN	NN	_	16	compound	_	_
13	factor	factor	NN	NN	_	16	compound	_	_
14	interleukin	interleukin	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL	il	NN	NN	_	9	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	-2	-2	CD	CD	_	16	nummod	_	_
19	,	,	,	,	_	22	punct	_	_
20	it	it	PRP	PRP	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	unclear	unclear	JJ	JJ	_	0	root	_	_
23	how	how	WRB	WRB	_	25	advmod	_	_
24	they	they	PRP	PRP	_	25	nsubj	_	_
25	participate	participate	VBP	VBP	_	22	ccomp	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IL-2-independent	il-2-independent	JJ	JJ	_	29	amod	_	_
29	growth	growth	NN	NN	_	25	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	certain	certain	JJ	JJ	_	10	amod	_	_
9	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	10	compound	_	_
10	members	member	NNS	NNS	_	15	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	predominantly	predominantly	RB	RB	_	13	advmod	_	_
13	c-Rel	c-rel	NN	NN	_	10	appos	_	_
14	,	,	,	,	_	10	punct	_	_
15	interact	interact	VBP	VBP	_	6	ccomp	_	_
16	with	with	IN	IN	_	18	case	_	_
17	enhancer	enhancer	NN	NN	_	18	compound	_	_
18	sequences	sequence	NNS	NNS	_	15	nmod	_	_
19	for	for	IN	IN	_	20	case	_	_
20	STAT5	stat5	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	a	a	DT	DT	_	25	det	_	_
23	key	key	JJ	JJ	_	25	amod	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	20	appos	_	_
26	mediating	mediate	VBG	VBG	_	25	acl	_	_
27	IL-2-induced	il-2-induced	JJ	JJ	_	29	amod	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	proliferation	proliferation	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Reporter	reporter	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	reveal	reveal	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	binding	binding	NN	NN	_	20	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	c-Rel	c-rel	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	STAT5	stat5	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	7	nmod	_	_
14	present	present	JJ	JJ	_	13	amod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	Fc	fc	NN	NN	_	19	compound	_	_
18	gammaR1	gammar1	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	14	nmod	_	_
20	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	potent	potent	JJ	JJ	_	23	amod	_	_
23	transactivation	transactivation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	enhancer	enhancer	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Binding	binding	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	c-Rel	c-rel	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Fc	fc	NN	NN	_	9	compound	_	_
7	gammaR1	gammar1	NN	NN	_	9	compound	_	_
8	STAT	stat	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	1	nmod	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	occurs	occur	VBZ	VBZ	_	0	root	_	_
12	in	in	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
15	blood	blood	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	immortalized	immortalize	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	20	case	_	_
20	HTLV-I	htlv-i	NN	NN	_	18	nmod	_	_
21	in	in	FW	FW	_	22	compound	_	_
22	vitro	vitro	FW	FW	_	18	advmod	_	_
23	and	and	CC	CC	_	11	cc	_	_
24	is	be	VBZ	VBZ	_	25	auxpass	_	_
25	correlated	correlate	VBN	VBN	_	11	conj	_	_
26	with	with	IN	IN	_	28	case	_	_
27	enhanced	enhance	VBN	VBN	_	28	amod	_	_
28	levels	level	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	proliferation	proliferation	NN	NN	_	28	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	these	these	DT	DT	_	33	det	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	raise	raise	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	NF-kappaB/Rel	nf-kappab/rel	NN	NN	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	participate	participate	VB	VB	_	5	ccomp	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	growth	growth	NN	NN	_	13	compound	_	_
13	control	control	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	HTLV-I-transformed	htlv-i-transformed	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	regulating	regulate	VBG	VBG	_	9	advcl	_	_
20	genes	gene	NNS	NNS	_	19	dobj	_	_
21	driven	drive	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	both	both	CC	CC	_	24	cc:preconj	_	_
24	kappaB	kappab	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	certain	certain	JJ	JJ	_	28	amod	_	_
27	STAT	stat	NN	NN	_	28	compound	_	_
28	enhancers	enhancer	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Crossreactive	crossreactive	JJ	JJ	_	2	amod	_	_
2	recognition	recognition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	11	case	_	_
4	viral	viral	JJ	JJ	_	11	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	self	self	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	bacterial	bacterial	JJ	JJ	_	4	conj	_	_
10	peptide	peptide	NN	NN	_	11	compound	_	_
11	ligands	ligand	NNS	NNS	_	2	nmod	_	_
12	by	by	IN	IN	_	19	case	_	_
13	human	human	JJ	JJ	_	19	amod	_	_
14	class	class	NN	NN	_	19	compound	_	_
15	I-restricted	i-restricted	JJ	JJ	_	19	amod	_	_
16	cytotoxic	cytotoxic	JJ	JJ	_	19	amod	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	clonotypes	clonotype	NNS	NNS	_	2	nmod	_	_
20	:	:	:	:	_	2	punct	_	_
21	implications	implication	NNS	NNS	_	2	dep	_	_
22	for	for	IN	IN	_	24	case	_	_
23	molecular	molecular	JJ	JJ	_	24	amod	_	_
24	mimicry	mimicry	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	autoimmune	autoimmune	JJ	JJ	_	27	amod	_	_
27	disease	disease	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	11	det	_	_
2	immunodominant	immunodominant	JJ	JJ	_	11	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	CD8(+)	cd8(+)	JJ	JJ	_	2	dep	_	_
5	cytotoxic	cytotoxic	JJ	JJ	_	11	amod	_	_
6	T	t	NN	NN	_	11	compound	_	_
7	lymphocyte	lymphocyte	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	CTL	ctl	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	response	response	NN	NN	_	30	nsubjpass	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	HLA-B8-restricted	hla-b8-restricted	JJ	JJ	_	15	amod	_	_
15	peptide	peptide	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	RAKFKQLL	rakfkqll	NN	NN	_	15	appos	_	_
18	,	,	,	,	_	15	punct	_	_
19	located	located	JJ	JJ	_	15	amod	_	_
20	in	in	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	Epstein-Barr	epstein-barr	JJ	JJ	_	25	amod	_	_
23	virus	virus	NN	NN	_	25	compound	_	_
24	immediate-early	immediate-early	JJ	JJ	_	25	amod	_	_
25	antigen	antigen	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	BZLF1	bzlf1	NN	NN	_	25	appos	_	_
28	,	,	,	,	_	25	punct	_	_
29	is	be	VBZ	VBZ	_	30	auxpass	_	_
30	characterized	characterize	VBN	VBN	_	0	root	_	_
31	by	by	IN	IN	_	40	case	_	_
32	a	a	DT	DT	_	40	det	_	_
33	diverse	diverse	JJ	JJ	_	40	amod	_	_
34	T	t	NN	NN	_	40	compound	_	_
35	cell	cell	NN	NN	_	40	compound	_	_
36	receptor	receptor	NN	NN	_	40	compound	_	_
37	(	(	-LRB-	-LRB-	_	40	punct	_	_
38	TCR	tcr	NN	NN	_	40	compound	_	_
39	)	)	-RRB-	-RRB-	_	40	punct	_	_
40	repertoire	repertoire	NN	NN	_	30	nmod	_	_
41	.	.	.	.	_	30	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	this	this	DT	DT	_	7	det	_	_
7	diversity	diversity	NN	NN	_	10	nsubjpass	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	partitioned	partition	VBN	VBN	_	4	ccomp	_	_
11	on	on	IN	IN	_	17	case	_	_
12	the	the	DT	DT	_	17	dep	_	_
13	basis	basis	NN	NN	_	17	dep	_	_
14	of	of	IN	IN	_	17	case	_	_
15	crossreactive	crossreactive	JJ	JJ	_	17	amod	_	_
16	cytotoxicity	cytotoxicity	NN	NN	_	17	compound	_	_
17	patterns	pattern	NNS	NNS	_	10	nmod	_	_
18	involving	involve	VBG	VBG	_	17	acl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	recognition	recognition	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	self	self	NN	NN	_	24	compound	_	_
24	peptide	peptide	NN	NN	_	20	nmod	_	_
25	-	-	:	:	_	24	punct	_	_
26	RSKFRQIV	rskfrqiv	NN	NN	_	24	dep	_	_
27	-	-	:	:	_	24	punct	_	_
28	located	located	JJ	JJ	_	24	amod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	serine/threonine	serine/threonine	NN	NN	_	32	compound	_	_
32	kinase	kinase	NN	NN	_	28	nmod	_	_
33	and	and	CC	CC	_	24	cc	_	_
34	a	a	DT	DT	_	36	det	_	_
35	bacterial	bacterial	JJ	JJ	_	36	amod	_	_
36	peptide	peptide	NN	NN	_	24	conj	_	_
37	-	-	:	:	_	36	punct	_	_
38	RRKYKQII	rrkykqii	NN	NN	_	36	dep	_	_
39	-	-	:	:	_	36	punct	_	_
40	located	located	JJ	JJ	_	36	amod	_	_
41	in	in	IN	IN	_	46	case	_	_
42	Staphylococcus	staphylococcus	FW	FW	_	46	compound	_	_
43	aureus	aureus	FW	FW	_	46	compound	_	_
44	replication	replication	NN	NN	_	46	compound	_	_
45	initiation	initiation	NN	NN	_	46	compound	_	_
46	protein	protein	NN	NN	_	40	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	CTL	ctl	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	14	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	recognized	recognize	VBD	VBD	_	3	acl:relcl	_	_
6	the	the	DT	DT	_	13	det	_	_
7	viral	viral	JJ	JJ	_	13	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	self	self	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	bacterial	bacterial	JJ	JJ	_	7	conj	_	_
13	peptides	peptide	NNS	NNS	_	5	dobj	_	_
14	expressed	express	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	20	det	_	_
16	highly	highly	RB	RB	_	17	advmod	_	_
17	restricted	restricted	JJ	JJ	_	20	amod	_	_
18	alphabeta	alphabeta	NN	NN	_	20	compound	_	_
19	TCR	tcr	NN	NN	_	20	compound	_	_
20	phenotype	phenotype	NN	NN	_	14	dobj	_	_
21	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	CTL	ctl	NN	NN	_	3	compound	_	_
3	clones	clone	NNS	NNS	_	12	nsubj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	recognized	recognize	VBD	VBD	_	3	acl:relcl	_	_
6	viral	viral	JJ	JJ	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	self	self	NN	NN	_	6	conj	_	_
9	peptides	peptide	NNS	NNS	_	5	dobj	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	oligoclonal	oligoclonal	JJ	JJ	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	whereas	whereas	IN	IN	_	12	dep	_	_
15	clones	clone	NNS	NNS	_	22	nsubj	_	_
16	that	that	WDT	WDT	_	18	nsubj	_	_
17	strictly	strictly	RB	RB	_	18	advmod	_	_
18	recognized	recognize	VBD	VBD	_	15	acl:relcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	viral	viral	JJ	JJ	_	21	amod	_	_
21	peptide	peptide	NN	NN	_	18	dobj	_	_
22	displayed	display	VBD	VBD	_	12	parataxis	_	_
23	a	a	DT	DT	_	26	det	_	_
24	diverse	diverse	JJ	JJ	_	26	amod	_	_
25	TCR	tcr	NN	NN	_	26	compound	_	_
26	profile	profile	NN	NN	_	22	dobj	_	_
27	.	.	.	.	_	12	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	self	self	NN	NN	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	bacterial	bacterial	JJ	JJ	_	4	conj	_	_
7	peptides	peptide	NNS	NNS	_	12	nsubj	_	_
8	equally	equally	RB	RB	_	12	advmod	_	_
9	were	be	VBD	VBD	_	12	cop	_	_
10	substantially	substantially	RB	RB	_	11	advmod	_	_
11	less	less	RBR	RBR	_	12	advmod	_	_
12	effective	effective	JJ	JJ	_	0	root	_	_
13	than	than	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	cognate	cognate	JJ	JJ	_	17	amod	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	peptide	peptide	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	sensitizing	sensitize	VBG	VBG	_	12	advcl	_	_
20	target	target	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lysis	lysis	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	12	punct	_	_
24	and	and	CC	CC	_	12	cc	_	_
25	also	also	RB	RB	_	12	advmod	_	_
26	resulted	result	VBD	VBD	_	12	dep	_	_
27	only	only	RB	RB	_	31	advmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	weak	weak	JJ	JJ	_	31	amod	_	_
31	reactivation	reactivation	NN	NN	_	26	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	memory	memory	NN	NN	_	34	compound	_	_
34	CTLs	ctl	NNS	NNS	_	31	nmod	_	_
35	in	in	IN	IN	_	36	mark	_	_
36	limiting	limit	VBG	VBG	_	26	advcl	_	_
37	dilution	dilution	NN	NN	_	38	compound	_	_
38	assays	assay	NNS	NNS	_	36	dobj	_	_
39	,	,	,	,	_	12	punct	_	_
40	whereas	whereas	IN	IN	_	12	dep	_	_
41	the	the	DT	DT	_	43	det	_	_
42	cognate	cognate	JJ	JJ	_	43	amod	_	_
43	peptide	peptide	NN	NN	_	46	nsubj	_	_
44	was	be	VBD	VBD	_	46	cop	_	_
45	highly	highly	RB	RB	_	46	advmod	_	_
46	immunogenic	immunogenic	JJ	JJ	_	12	parataxis	_	_
47	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	described	describe	VBN	VBN	_	3	amod	_	_
3	crossreactions	crossreaction	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	human	human	JJ	JJ	_	11	amod	_	_
7	antiviral	antiviral	JJ	JJ	_	11	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	CD8(+)	cd8(+)	JJ	JJ	_	7	dep	_	_
10	CTL	ctl	NN	NN	_	11	compound	_	_
11	responses	response	NNS	NNS	_	14	nsubjpass	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	shaped	shape	VBN	VBN	_	4	ccomp	_	_
15	by	by	IN	IN	_	17	case	_	_
16	peptide	peptide	NN	NN	_	17	compound	_	_
17	ligands	ligand	NNS	NNS	_	14	nmod	_	_
18	derived	derive	VBN	VBN	_	17	acl	_	_
19	from	from	IN	IN	_	20	case	_	_
20	autoantigens	autoantigen	NNS	NNS	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	environmental	environmental	JJ	JJ	_	24	amod	_	_
23	bacterial	bacterial	JJ	JJ	_	24	amod	_	_
24	antigens	antigen	NNS	NNS	_	20	conj	_	_
25	,	,	,	,	_	4	punct	_	_
26	thereby	thereby	RB	RB	_	27	advmod	_	_
27	providing	provide	VBG	VBG	_	4	xcomp	_	_
28	a	a	DT	DT	_	31	det	_	_
29	firm	firm	JJ	JJ	_	31	amod	_	_
30	structural	structural	JJ	JJ	_	31	amod	_	_
31	basis	basis	NN	NN	_	27	dobj	_	_
32	for	for	IN	IN	_	34	case	_	_
33	molecular	molecular	JJ	JJ	_	34	amod	_	_
34	mimicry	mimicry	NN	NN	_	31	nmod	_	_
35	involving	involve	VBG	VBG	_	34	acl	_	_
36	class	class	NN	NN	_	38	compound	_	_
37	I-restricted	i-restricted	JJ	JJ	_	38	amod	_	_
38	CTLs	ctl	NNS	NNS	_	35	dobj	_	_
39	in	in	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	pathogenesis	pathogenesis	NN	NN	_	38	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	autoimmune	autoimmune	JJ	JJ	_	44	amod	_	_
44	disease	disease	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	AML	aml	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Ets	ets	NN	NN	_	1	conj	_	_
4	proteins	protein	NNS	NNS	_	5	nsubj	_	_
5	regulate	regulate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	10	det	_	_
7	I	i	NN	NN	_	10	compound	_	_
8	alpha1	alpha1	NN	NN	_	10	compound	_	_
9	germ-line	germ-line	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	5	dobj	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	10	det	_	_
2	immunoglobulin	immunoglobulin	NN	NN	_	4	compound	_	_
3	heavy	heavy	JJ	JJ	_	4	amod	_	_
4	chain	chain	NN	NN	_	10	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IgH	igh	JJ	JJ	_	4	dep	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	class	class	NN	NN	_	10	compound	_	_
9	switch	switch	NN	NN	_	10	compound	_	_
10	recombination	recombination	NN	NN	_	15	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	preferentially	preferentially	RB	RB	_	15	advmod	_	_
15	targets	target	VBZ	VBZ	_	0	root	_	_
16	unrearranged	unrearranged	JJ	JJ	_	18	amod	_	_
17	IgH	igh	JJ	JJ	_	18	amod	_	_
18	genes	gene	NNS	NNS	_	15	dobj	_	_
19	that	that	WDT	WDT	_	23	nsubjpass	_	_
20	have	have	VBP	VBP	_	23	aux	_	_
21	already	already	RB	RB	_	23	advmod	_	_
22	been	be	VBN	VBN	_	23	auxpass	_	_
23	rendered	render	VBN	VBN	_	18	acl:relcl	_	_
24	transcriptionally	transcriptionally	RB	RB	_	25	advmod	_	_
25	active	active	JJ	JJ	_	23	xcomp	_	_
26	.	.	.	.	_	15	punct	_	_

1	Transcription	transcription	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	germ-line	germ-line	NN	NN	_	6	compound	_	_
5	IgH	igh	JJ	JJ	_	6	amod	_	_
6	genes	gene	NNS	NNS	_	1	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	controlled	control	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	14	case	_	_
10	intervening	intervene	VBG	VBG	_	14	amod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	I	i	CD	CD	_	14	nummod	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	regions	region	NNS	NNS	_	8	nmod	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	switch	switch	NN	NN	_	19	compound	_	_
19	regions	region	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	I	i	NN	NN	_	4	compound	_	_
3	alpha1	alpha1	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	nsubj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	human	human	JJ	JJ	_	13	amod	_	_
10	germ-line	germ-line	NN	NN	_	13	compound	_	_
11	C	c	NN	NN	_	13	compound	_	_
12	alpha1	alpha1	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	6	nmod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	IgA1	iga1	NN	NN	_	6	nmod	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	mediates	mediate	VBZ	VBZ	_	5	conj	_	_
18	the	the	DT	DT	_	26	det	_	_
19	transforming	transform	VBG	VBG	_	26	amod	_	_
20	growth	growth	NN	NN	_	26	compound	_	_
21	factor	factor	NN	NN	_	26	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	TGF	tgf	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	-beta1	-beta1	NN	NN	_	26	compound	_	_
26	responsiveness	responsiveness	NN	NN	_	17	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	locus	locus	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	I	i	NN	NN	_	8	compound	_	_
7	alpha1	alpha1	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	9	nsubj	_	_
9	contains	contain	VBZ	VBZ	_	3	ccomp	_	_
10	several	several	JJ	JJ	_	12	amod	_	_
11	binding	bind	VBG	VBG	_	12	amod	_	_
12	sites	site	NNS	NNS	_	9	dobj	_	_
13	for	for	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	AML/PEBP2/CBF	aml/pebp2/cbf	NN	NN	_	19	compound	_	_
16	family	family	NN	NN	_	19	compound	_	_
17	of	of	IN	IN	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	12	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	AML	aml	NN	NN	_	25	compound	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	Ets	ets	NN	NN	_	22	conj	_	_
25	proteins	protein	NNS	NNS	_	28	nsubj	_	_
26	are	be	VBP	VBP	_	28	cop	_	_
27	major	major	JJ	JJ	_	28	amod	_	_
28	regulators	regulator	NNS	NNS	_	9	conj	_	_
29	of	of	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	basal	basal	JJ	JJ	_	35	amod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	TGF-beta-inducible	tgf-beta-inducible	JJ	JJ	_	31	conj	_	_
34	promoter	promoter	NN	NN	_	35	compound	_	_
35	activity	activity	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	constitute	constitute	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	starting	start	VBG	VBG	_	6	amod	_	_
6	point	point	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	10	mark	_	_
8	studies	study	NNS	NNS	_	10	nsubj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	elucidate	elucidate	VB	VB	_	6	acl	_	_
11	the	the	DT	DT	_	13	det	_	_
12	molecular	molecular	JJ	JJ	_	13	amod	_	_
13	mechanism	mechanism	NN	NN	_	10	dobj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	which	which	WDT	WDT	_	17	nmod	_	_
16	TGF-beta	tgf-beta	NN	NN	_	17	nsubj	_	_
17	regulates	regulate	VBZ	VBZ	_	13	acl:relcl	_	_
18	IgA	iga	NN	NN	_	19	compound	_	_
19	production	production	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	4	amod	_	_
2	blood	blood	NN	NN	_	4	compound	_	_
3	mononuclear	mononuclear	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	11	nsubj	_	_
5	isolated	isolate	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	diabetic	diabetic	JJ	JJ	_	10	amod	_	_
10	nephropathy	nephropathy	NN	NN	_	7	nmod	_	_
11	show	show	VBP	VBP	_	0	root	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	oxidative-stress	oxidative-stress	NN	NN	_	20	compound	_	_
17	sensitive	sensitive	JJ	JJ	_	20	amod	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Increased	increase	VBN	VBN	_	3	amod	_	_
2	oxidative	oxidative	JJ	JJ	_	3	amod	_	_
3	stress	stress	NN	NN	_	14	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	subsequent	subsequent	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	6	nmod	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	linked	link	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	development	development	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	late	late	JJ	JJ	_	21	amod	_	_
20	diabetic	diabetic	JJ	JJ	_	21	amod	_	_
21	complications	complication	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	17	dep	_	_
3	whether	whether	IN	IN	_	10	mark	_	_
4	oxidative	oxidative	JJ	JJ	_	6	amod	_	_
5	stress	stress	NN	NN	_	6	nmod:npmod	_	_
6	dependent	dependent	JJ	JJ	_	8	amod	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	evident	evident	JJ	JJ	_	2	ccomp	_	_
11	in	in	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	diabetic	diabetic	JJ	JJ	_	15	amod	_	_
15	nephropathy	nephropathy	NN	NN	_	12	nmod	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	used	use	VBD	VBD	_	0	root	_	_
18	an	a	DT	DT	_	26	det	_	_
19	Electrophoretic	electrophoretic	JJ	JJ	_	23	amod	_	_
20	Mobility	mobility	NN	NN	_	23	nmod:npmod	_	_
21	Shift	shift	NN	NN	_	23	nmod:npmod	_	_
22	Assay	assay	NN	NN	_	23	nmod:npmod	_	_
23	based	based	JJ	JJ	_	26	amod	_	_
24	semiquantitative	semiquantitative	JJ	JJ	_	26	amod	_	_
25	detection	detection	NN	NN	_	26	compound	_	_
26	system	system	NN	NN	_	17	dobj	_	_
27	which	which	WDT	WDT	_	28	nsubj	_	_
28	enabled	enable	VBD	VBD	_	26	acl:relcl	_	_
29	us	we	PRP	PRP	_	28	dobj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	determine	determine	VB	VB	_	28	xcomp	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	31	dobj	_	_
34	in	in	IN	IN	_	41	case	_	_
35	ex	ex	FW	FW	_	41	amod	_	_
36	vivo	vivo	FW	FW	_	35	dep	_	_
37	isolated	isolate	VBN	VBN	_	41	amod	_	_
38	peripheral	peripheral	JJ	JJ	_	41	amod	_	_
39	blood	blood	NN	NN	_	41	compound	_	_
40	mononuclear	mononuclear	JJ	JJ	_	41	amod	_	_
41	cells	cell	NNS	NNS	_	33	nmod	_	_
42	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	33	33	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	2	dobj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	diabetes	diabetes	NN	NN	_	7	compound	_	_
7	mellitus	mellitus	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	Type	type	NN	NN	_	7	dep	_	_
10	I	i	CD	CD	_	9	nummod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	Type	type	NN	NN	_	9	conj	_	_
13	II	ii	CD	CD	_	12	nummod	_	_
14	)	)	-RRB-	-RRB-	_	9	punct	_	_
15	.	.	.	.	_	2	punct	_	_

1	Patients	patient	NNS	NNS	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	diabetic	diabetic	JJ	JJ	_	4	amod	_	_
4	nephropathy	nephropathy	NN	NN	_	1	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	higher	higher	JJR	JJR	_	9	amod	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	Electrophoretic	electrophoretic	JJ	JJ	_	14	amod	_	_
12	Mobility	mobility	NN	NN	_	14	compound	_	_
13	Shift	shift	NN	NN	_	14	compound	_	_
14	Assays	assay	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	stronger	stronger	JJR	JJR	_	18	amod	_	_
17	immunohistological	immunohistological	JJ	JJ	_	18	amod	_	_
18	staining	staining	NN	NN	_	9	conj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	activated	activate	VBN	VBN	_	21	amod	_	_
21	NF-kappaBp65	nf-kappabp65	NN	NN	_	18	nmod	_	_
22	than	than	IN	IN	_	23	case	_	_
23	patients	patient	NNS	NNS	_	9	nmod	_	_
24	without	without	IN	IN	_	26	case	_	_
25	renal	renal	JJ	JJ	_	26	amod	_	_
26	complications	complication	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	4	nsubj	_	_
4	correlated	correlate	VBD	VBD	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	degree	degree	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	albuminuria	albuminuria	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	r	r	NN	NN	_	12	nsubj	_	_
12	=	=	JJ	JJ	_	7	dep	_	_
13	0.316	0.316	CD	CD	_	12	dobj	_	_
14	)	)	-RRB-	-RRB-	_	12	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	with	with	IN	IN	_	19	case	_	_
17	thrombomodulin	thrombomodulin	NN	NN	_	19	compound	_	_
18	plasma	plasma	NN	NN	_	19	compound	_	_
19	concentrations	concentration	NNS	NNS	_	7	conj	_	_
20	(	(	-LRB-	-LRB-	_	22	punct	_	_
21	r	r	NN	NN	_	22	nsubj	_	_
22	=	=	JJ	JJ	_	19	dep	_	_
23	0.33	0.33	CD	CD	_	22	dobj	_	_
24	)	)	-RRB-	-RRB-	_	22	punct	_	_
25	,	,	,	,	_	4	punct	_	_
26	indicative	indicative	JJ	JJ	_	4	xcomp	_	_
27	for	for	IN	IN	_	31	case	_	_
28	albuminuria	albuminuria	NN	NN	_	29	nmod:npmod	_	_
29	associated	associated	JJ	JJ	_	31	amod	_	_
30	endothelial	endothelial	JJ	JJ	_	31	amod	_	_
31	dysfunction	dysfunction	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	a	a	DT	DT	_	6	det	_	_
3	3	3	CD	CD	_	4	compound	_	_
4	day	day	NN	NN	_	6	amod	_	_
5	intervention	intervention	NN	NN	_	6	compound	_	_
6	study	study	NN	NN	_	36	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	23	nmod	_	_
9	600	600	CD	CD	_	10	nummod	_	_
10	mg	mg	NN	NN	_	23	nsubjpass	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	antioxidant	antioxidant	JJ	JJ	_	15	amod	_	_
14	thioctic	thioctic	JJ	JJ	_	15	amod	_	_
15	acid	acid	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	18	punct	_	_
17	alpha-lipoic	alpha-lipoic	JJ	JJ	_	18	amod	_	_
18	acid	acid	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	per	per	IN	IN	_	21	case	_	_
21	day	day	NN	NN	_	10	nmod	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	given	give	VBN	VBN	_	6	acl:relcl	_	_
24	to	to	TO	TO	_	26	case	_	_
25	nine	nine	CD	CD	_	26	nummod	_	_
26	patients	patient	NNS	NNS	_	23	nmod	_	_
27	with	with	IN	IN	_	29	case	_	_
28	diabetic	diabetic	JJ	JJ	_	29	amod	_	_
29	nephropathy	nephropathy	NN	NN	_	26	nmod	_	_
30	oxidative	oxidative	JJ	JJ	_	31	amod	_	_
31	stress	stress	NN	NN	_	36	nsubjpass	_	_
32	in	in	IN	IN	_	34	case	_	_
33	plasma	plasma	NN	NN	_	34	compound	_	_
34	samples	sample	NNS	NNS	_	31	nmod	_	_
35	was	be	VBD	VBD	_	36	auxpass	_	_
36	decreased	decrease	VBN	VBN	_	0	root	_	_
37	by	by	IN	IN	_	39	case	_	_
38	48	48	CD	CD	_	39	nummod	_	_
39	%	%	NN	NN	_	36	nmod	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	NF-kappaB	nf-kappab	NN	NN	_	43	compound	_	_
42	binding	binding	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	36	conj	_	_
44	in	in	IN	IN	_	51	case	_	_
45	ex	ex	FW	FW	_	51	amod	_	_
46	vivo	vivo	FW	FW	_	45	dep	_	_
47	isolated	isolate	VBN	VBN	_	51	amod	_	_
48	peripheral	peripheral	JJ	JJ	_	51	amod	_	_
49	blood	blood	NN	NN	_	51	compound	_	_
50	mononuclear	mononuclear	JJ	JJ	_	51	amod	_	_
51	cells	cell	NNS	NNS	_	43	nmod	_	_
52	by	by	IN	IN	_	54	case	_	_
53	38	38	CD	CD	_	54	nummod	_	_
54	%	%	NN	NN	_	43	dep	_	_
55	.	.	.	.	_	36	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	23	nmod	_	_
3	,	,	,	,	_	23	punct	_	_
4	activation	activation	NN	NN	_	23	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	17	case	_	_
11	ex	ex	FW	FW	_	17	amod	_	_
12	vivo	vivo	FW	FW	_	11	dep	_	_
13	isolated	isolate	VBN	VBN	_	17	amod	_	_
14	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
15	blood	blood	NN	NN	_	17	compound	_	_
16	mononuclear	mononuclear	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	4	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	diabetes	diabetes	NN	NN	_	22	compound	_	_
22	mellitus	mellitus	NN	NN	_	19	nmod	_	_
23	correlates	correlate	VBZ	VBZ	_	0	root	_	_
24	with	with	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	degree	degree	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	diabetic	diabetic	JJ	JJ	_	29	amod	_	_
29	nephropathy	nephropathy	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	8	nsubj	_	_
3	is	be	VBZ	VBZ	_	8	cop	_	_
4	at	at	IN	IN	_	7	advmod	_	_
5	least	least	JJS	JJS	_	4	mwe	_	_
6	in	in	IN	IN	_	7	case	_	_
7	part	part	NN	NN	_	8	nmod	_	_
8	dependent	dependent	JJ	JJ	_	0	root	_	_
9	on	on	IN	IN	_	11	case	_	_
10	oxidative	oxidative	JJ	JJ	_	11	amod	_	_
11	stress	stress	NN	NN	_	8	nmod	_	_
12	since	since	IN	IN	_	19	mark	_	_
13	thioctic	thioctic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	19	nsubj	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	alpha-lipoic	alpha-lipoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	reduced	reduce	VBD	VBD	_	8	advcl	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	human	human	JJ	JJ	_	8	amod	_	_
4	immunodeficiency	immunodeficiency	NN	NN	_	8	compound	_	_
5	virus	virus	NN	NN	_	8	compound	_	_
6	type	type	NN	NN	_	8	compound	_	_
7	1	1	CD	CD	_	8	nummod	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	Gardnerella	gardnerella	FW	FW	_	11	compound	_	_
11	vaginalis	vaginalis	FW	FW	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	vaginosis	vaginosis	NN	NN	_	7	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	BV	bv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	rate	rate	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	sexual	sexual	JJ	JJ	_	14	amod	_	_
14	transmission	transmission	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	22	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
18	virus	virus	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	HIV	hiv	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	type	type	NN	NN	_	14	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	,	,	,	,	_	7	punct	_	_
25	and	and	CC	CC	_	7	cc	_	_
26	Gardnerella	gardnerella	FW	FW	_	27	compound	_	_
27	vaginalis	vaginalis	FW	FW	_	30	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	30	auxpass	_	_
29	frequently	frequently	RB	RB	_	30	advmod	_	_
30	isolated	isolate	VBN	VBN	_	7	conj	_	_
31	from	from	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	genital	genital	JJ	JJ	_	34	amod	_	_
34	tracts	tract	NNS	NNS	_	30	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	women	woman	NNS	NNS	_	34	nmod	_	_
37	with	with	IN	IN	_	38	case	_	_
38	BV	bv	NN	NN	_	36	nmod	_	_
39	.	.	.	.	_	7	punct	_	_

1	G.	g.	FW	FW	_	3	compound	_	_
2	vaginalis	vaginalis	FW	FW	_	3	compound	_	_
3	lysates	lysate	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	stimulate	stimulate	VB	VB	_	5	xcomp	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	monocytoid	monocytoid	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	4	nsubj	_	_
2	was	be	VBD	VBD	_	4	cop	_	_
3	significantly	significantly	RB	RB	_	4	advmod	_	_
4	higher	higher	JJR	JJR	_	0	root	_	_
5	when	when	WRB	WRB	_	8	advmod	_	_
6	lysates	lysate	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	heated	heat	VBN	VBN	_	4	advcl	_	_
9	at	at	IN	IN	_	11	case	_	_
10	100	100	CD	CD	_	11	nummod	_	_
11	degrees	degree	NNS	NNS	_	8	nmod	_	_
12	C	c	NN	NN	_	11	amod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	5	5	CD	CD	_	15	nummod	_	_
15	min	min	NN	NN	_	8	nmod	_	_
16	but	but	CC	CC	_	4	cc	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	reduced	reduce	VBN	VBN	_	4	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	treatment	treatment	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	lysozyme	lysozyme	NN	NN	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	protease	protease	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	G.	g.	FW	FW	_	3	compound	_	_
2	vaginalis	vaginalis	FW	FW	_	3	compound	_	_
3	lysates	lysate	NNS	NNS	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	activated	activate	VBD	VBD	_	0	root	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	certain	certain	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	lines	line	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	G.	g.	FW	FW	_	3	compound	_	_
2	vaginalis	vaginalis	FW	FW	_	3	compound	_	_
3	lysates	lysate	NNS	NNS	_	4	nsubj	_	_
4	activated	activate	VBD	VBD	_	0	root	_	_
5	HIV	hiv	NN	NN	_	8	compound	_	_
6	long-terminal	long-terminal	JJ	JJ	_	8	amod	_	_
7	repeat	repeat	NN	NN	_	8	compound	_	_
8	transcription	transcription	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	HIV-infected	hiv-infected	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	increased	increase	VBD	VBD	_	4	conj	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	4	punct	_	_
18	indicating	indicate	VBG	VBG	_	4	advcl	_	_
19	an	a	DT	DT	_	20	det	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	by	by	IN	IN	_	23	case	_	_
22	G.	g.	FW	FW	_	23	compound	_	_
23	vaginalis	vaginalis	FW	FW	_	20	nmod	_	_
24	on	on	IN	IN	_	26	case	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	HIV	hiv	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	G.	g.	FW	FW	_	8	compound	_	_
8	vaginalis	vaginalis	FW	FW	_	2	nmod	_	_
9	suggests	suggest	VBZ	VBZ	_	0	root	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	genital	genital	JJ	JJ	_	13	amod	_	_
12	tract	tract	NN	NN	_	13	compound	_	_
13	infection	infection	NN	NN	_	17	nsubj	_	_
14	with	with	IN	IN	_	16	case	_	_
15	G.	g.	FW	FW	_	16	compound	_	_
16	vaginalis	vaginalis	FW	FW	_	13	nmod	_	_
17	increases	increase	VBZ	VBZ	_	9	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	risk	risk	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	HIV	hiv	NN	NN	_	22	compound	_	_
22	transmission	transmission	NN	NN	_	19	nmod	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	increasing	increase	VBG	VBG	_	17	advcl	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	genital	genital	JJ	JJ	_	30	amod	_	_
30	tract	tract	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	explain	explain	VB	VB	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	at	at	IN	IN	_	8	advmod	_	_
6	least	least	JJS	JJS	_	5	mwe	_	_
7	in	in	IN	IN	_	8	case	_	_
8	part	part	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	the	the	DT	DT	_	12	det	_	_
11	increased	increase	VBN	VBN	_	12	amod	_	_
12	rate	rate	NN	NN	_	3	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	HIV	hiv	NN	NN	_	15	compound	_	_
15	transmission	transmission	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	women	woman	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	BV	bv	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interferon-alpha	interferon-alpha	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	multiple	multiple	JJ	JJ	_	5	amod	_	_
4	STAT	stat	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	2	dobj	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	upregulates	upregulate	VBZ	VBZ	_	2	conj	_	_
8	proliferation-associated	proliferation-associated	JJ	JJ	_	9	amod	_	_
9	IL-2Ralpha	il-2ralpha	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	c-myc	c-myc	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	pim-1	pim-1	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	9	conj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	9	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Interferon-alpha	interferon-alpha	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFN-alpha	ifn-alpha	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	pleiotropic	pleiotropic	JJ	JJ	_	8	amod	_	_
8	cytokine	cytokine	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	has	have	VBZ	VBZ	_	8	acl:relcl	_	_
11	antiviral	antiviral	JJ	JJ	_	17	amod	_	_
12	,	,	,	,	_	11	punct	_	_
13	antiproliferative	antiproliferative	JJ	JJ	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	immunoregulatory	immunoregulatory	JJ	JJ	_	11	conj	_	_
17	functions	function	NNS	NNS	_	10	dobj	_	_
18	.	.	.	.	_	8	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	increasing	increase	VBG	VBG	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	2	nsubj	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	4	ccomp	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	biology	biology	NN	NN	_	7	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	analyzed	analyze	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-2Ralpha	il-2ralpha	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	c-myc	c-myc	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	pim-1	pim-1	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	7	conj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	anti-CD3-activated	anti-cd3-activated	JJ	JJ	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	induction	induction	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	genes	gene	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	15	case	_	_
9	interleukin-2	interleukin-2	NN	NN	_	13	nmod:npmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-2	il-2	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	-induced	-induced	JJ	JJ	_	15	amod	_	_
14	T-cell	t-cell	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	7	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IFN-alpha	ifn-alpha	NN	NN	_	1	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	IL-2	il-2	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	IL-12	il-12	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	IL-15	il-15	NN	NN	_	6	conj	_	_
14	upregulated	upregulate	VBD	VBD	_	0	root	_	_
15	IL-2Ralpha	il-2ralpha	NN	NN	_	17	compound	_	_
16	,	,	,	,	_	17	punct	_	_
17	c-myc	c-myc	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	pim-1	pim-1	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	14	punct	_	_

1	IFN-alpha	ifn-alpha	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	sensitized	sensitize	VBD	VBD	_	0	root	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	3	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	IL-2-induced	il-2-induced	JJ	JJ	_	8	amod	_	_
8	proliferation	proliferation	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	further	further	RBR	RBR	_	11	advmod	_	_
11	suggesting	suggest	VBG	VBG	_	3	advcl	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	IFN-alpha	ifn-alpha	NN	NN	_	16	nsubjpass	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	11	ccomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T-cell	t-cell	NN	NN	_	22	compound	_	_
22	mitogenesis	mitogenesis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	When	when	WRB	WRB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	analyzed	analyze	VBD	VBD	_	26	advcl	_	_
4	the	the	DT	DT	_	5	det	_	_
5	nature	nature	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT	stat	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	capable	capable	JJ	JJ	_	8	amod	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	binding	bind	VBG	VBG	_	9	advcl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	IL-2Ralpha	il-2ralpha	NN	NN	_	15	compound	_	_
14	,	,	,	,	_	15	punct	_	_
15	pim-1	pim-1	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	and	and	CC	CC	_	15	cc	_	_
18	IRF-1	irf-1	NN	NN	_	20	compound	_	_
19	GAS	gas	NN	NN	_	20	compound	_	_
20	elements	element	NNS	NNS	_	15	conj	_	_
21	after	after	IN	IN	_	23	case	_	_
22	cytokine	cytokine	NN	NN	_	23	compound	_	_
23	stimulation	stimulation	NN	NN	_	5	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	observed	observe	VBD	VBD	_	0	root	_	_
27	IFN-alpha-induced	ifn-alpha-induced	JJ	JJ	_	28	amod	_	_
28	binding	binding	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	STAT1	stat1	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	STAT3	stat3	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	30	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	STAT4	stat4	NN	NN	_	30	conj	_	_
36	,	,	,	,	_	30	punct	_	_
37	but	but	CC	CC	_	38	cc	_	_
38	not	not	RB	RB	_	30	cc	_	_
39	STAT5	stat5	NN	NN	_	30	conj	_	_
40	to	to	TO	TO	_	41	case	_	_
41	all	all	DT	DT	_	28	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	these	these	DT	DT	_	44	det	_	_
44	elements	element	NNS	NNS	_	41	nmod	_	_
45	.	.	.	.	_	26	punct	_	_

1	Yet	yet	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	IFN-alpha	ifn-alpha	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	activate	activate	VB	VB	_	5	xcomp	_	_
8	binding	binding	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT5	stat5	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	high-affinity	high-affinity	JJ	JJ	_	16	amod	_	_
14	IFP53	ifp53	NN	NN	_	16	compound	_	_
15	GAS	gas	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	8	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	IFN-alpha	ifn-alpha	NN	NN	_	2	nsubj	_	_
2	enhanced	enhance	VBD	VBD	_	0	root	_	_
3	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
4	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STAT1	stat1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	STAT3	stat3	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	STAT4	stat4	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	STAT5a	stat5a	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	STAT5b	stat5b	NN	NN	_	6	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	IL-12	il-12	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	STAT4	stat4	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	2	cc	_	_
5	IL-2	il-2	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-15	il-15	NN	NN	_	5	conj	_	_
8	induced	induce	VBD	VBD	_	2	conj	_	_
9	STAT5	stat5	NN	NN	_	8	dobj	_	_
10	binding	binding	NN	NN	_	2	dep	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	GAS	gas	NN	NN	_	14	compound	_	_
14	elements	element	NNS	NNS	_	2	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	16	mark	_	_
8	IFN-alpha	ifn-alpha	NN	NN	_	16	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	IL-2	il-2	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	IL-12	il-12	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	IL-15	il-15	NN	NN	_	8	conj	_	_
16	have	have	VBP	VBP	_	6	ccomp	_	_
17	overlapping	overlap	VBG	VBG	_	18	amod	_	_
18	activities	activity	NNS	NNS	_	16	dobj	_	_
19	on	on	IN	IN	_	22	case	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	emphasize	emphasize	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	importance	importance	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IFN-alpha	ifn-alpha	NN	NN	_	6	nmod	_	_
9	as	as	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	T-cell	t-cell	NN	NN	_	13	compound	_	_
12	regulatory	regulatory	JJ	JJ	_	13	amod	_	_
13	cytokine	cytokine	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Anti-rheumatic	anti-rheumatic	JJ	JJ	_	3	amod	_	_
2	compound	compound	NN	NN	_	3	compound	_	_
3	aurothioglucose	aurothioglucose	NN	NN	_	4	nsubj	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	tumor	tumor	NN	NN	_	7	nmod:npmod	_	_
6	necrosis	necrosis	NN	NN	_	7	nmod:npmod	_	_
7	factor-alpha-induced	factor-alpha-induced	JJ	JJ	_	9	amod	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	replication	replication	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	latently	latently	RB	RB	_	12	advmod	_	_
12	infected	infected	JJ	JJ	_	13	amod	_	_
13	OM10.1	om10.1	NN	NN	_	4	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	Ach2	ach2	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	10	case	_	_
8	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Down-regulation	down-regulation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	inhibit	inhibit	VB	VB	_	6	xcomp	_	_
9	HIV	hiv	NN	NN	_	10	compound	_	_
10	replication	replication	NN	NN	_	8	dobj	_	_
11	from	from	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	latently	latently	RB	RB	_	15	advmod	_	_
14	infected	infected	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Gold	gold	NN	NN	_	2	compound	_	_
2	compounds	compound	NNS	NNS	_	6	nsubjpass	_	_
3	have	have	VBP	VBP	_	6	aux	_	_
4	been	be	VBN	VBN	_	6	auxpass	_	_
5	effectively	effectively	RB	RB	_	6	advmod	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	many	many	JJ	JJ	_	9	amod	_	_
9	decades	decade	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	treatment	treatment	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	rheumatoid	rheumatoid	JJ	JJ	_	15	amod	_	_
15	arthritis	arthritis	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	gold	gold	NN	NN	_	6	compound	_	_
6	compounds	compound	NNS	NNS	_	18	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	especially	especially	RB	RB	_	9	advmod	_	_
9	aurothioglucose	aurothioglucose	NN	NN	_	6	appos	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AuTG	autg	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	containing	contain	VBG	VBG	_	9	acl	_	_
14	monovalent	monovalent	JJ	JJ	_	16	amod	_	_
15	gold	gold	NN	NN	_	16	compound	_	_
16	ion	ion	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	6	punct	_	_
18	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
19	the	the	DT	DT	_	20	det	_	_
20	DNA-binding	dna-binding	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	nmod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	18	advmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	examined	examine	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	efficacy	efficacy	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	gold	gold	NN	NN	_	13	compound	_	_
12	compound	compound	NN	NN	_	13	compound	_	_
13	AuTG	autg	NN	NN	_	8	nmod	_	_
14	as	as	IN	IN	_	16	case	_	_
15	an	a	DT	DT	_	16	det	_	_
16	inhibitor	inhibitor	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	latently	latently	RB	RB	_	22	advmod	_	_
22	infected	infected	JJ	JJ	_	23	amod	_	_
23	OM10.1	om10.1	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Ach2	ach2	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Tumor	tumor	NN	NN	_	7	nmod:npmod	_	_
2	necrosis	necrosis	NN	NN	_	7	nmod:npmod	_	_
3	factor	factor	NN	NN	_	7	nmod:npmod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	TNF	tnf	NN	NN	_	7	nmod:npmod	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	-alpha-induced	-alpha-induced	JJ	JJ	_	9	amod	_	_
8	HIV-1	hiv-1	NN	NN	_	9	compound	_	_
9	replication	replication	NN	NN	_	17	nsubjpass	_	_
10	in	in	IN	IN	_	14	case	_	_
11	OM10.1	om10.1	NN	NN	_	14	compound	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	Ach2	ach2	NN	NN	_	11	conj	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	inhibited	inhibit	VBN	VBN	_	0	root	_	_
18	by	by	IN	IN	_	20	case	_	_
19	non-cytotoxic	non-cytotoxic	JJ	JJ	_	20	amod	_	_
20	doses	dose	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	AuTG	autg	NN	NN	_	20	nmod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	&gt;	&gt;	JJR	JJR	_	25	advmod	_	_
25	10	10	CD	CD	_	26	nummod	_	_
26	microM	microm	NN	NN	_	20	dep	_	_
27	in	in	IN	IN	_	29	case	_	_
28	OM10.1	om10.1	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	&gt;	&gt;	JJR	JJR	_	32	advmod	_	_
32	25	25	CD	CD	_	33	nummod	_	_
33	F.M	f.m	NN	NN	_	26	conj	_	_
34	in	in	IN	IN	_	36	case	_	_
35	Ach2	ach2	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	nmod	_	_
37	)	)	-RRB-	-RRB-	_	26	punct	_	_
38	,	,	,	,	_	17	punct	_	_
39	while	while	IN	IN	_	59	mark	_	_
40	25	25	CD	CD	_	41	nummod	_	_
41	microM	microm	NN	NN	_	59	nsubj	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	counter-anion	counter-anion	JJ	JJ	_	45	amod	_	_
45	thioglucose	thioglucose	NN	NN	_	41	nmod	_	_
46	(	(	-LRB-	-LRB-	_	47	punct	_	_
47	TG	tg	NN	NN	_	45	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	or	or	CC	CC	_	45	cc	_	_
50	gold	gold	NN	NN	_	51	compound	_	_
51	compound	compound	NN	NN	_	45	conj	_	_
52	containing	contain	VBG	VBG	_	51	acl	_	_
53	divalent	divalent	JJ	JJ	_	55	amod	_	_
54	gold	gold	NN	NN	_	55	compound	_	_
55	ion	ion	NN	NN	_	52	dobj	_	_
56	,	,	,	,	_	51	punct	_	_
57	HAuCl3	haucl3	NN	NN	_	51	appos	_	_
58	,	,	,	,	_	51	punct	_	_
59	had	have	VBD	VBD	_	17	advcl	_	_
60	no	no	DT	DT	_	61	neg	_	_
61	effect	effect	NN	NN	_	59	dobj	_	_
62	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AuTG	autg	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	8	case	_	_
6	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	8	amod	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	2	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	confirmed	confirm	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	transient	transient	JJ	JJ	_	15	amod	_	_
14	CAT	cat	NN	NN	_	15	compound	_	_
15	assay	assay	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	staining	staining	NN	NN	_	9	nsubj	_	_
3	as	as	RB	RB	_	2	cc	_	_
4	well	well	RB	RB	_	3	mwe	_	_
5	as	as	IN	IN	_	3	mwe	_	_
6	electron	electron	NN	NN	_	8	compound	_	_
7	microscopic	microscopic	JJ	JJ	_	8	amod	_	_
8	examinations	examination	NNS	NNS	_	2	conj	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	accumulation	accumulation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	metal	metal	NN	NN	_	14	compound	_	_
14	gold	gold	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	supporting	support	VBG	VBG	_	9	advcl	_	_
20	our	we	PRP$	PRP$	_	22	nmod:poss	_	_
21	previous	previous	JJ	JJ	_	22	amod	_	_
22	hypothesis	hypothesis	NN	NN	_	19	dobj	_	_
23	that	that	IN	IN	_	27	mark	_	_
24	gold	gold	NN	NN	_	25	compound	_	_
25	ions	ion	NNS	NNS	_	27	nsubj	_	_
26	could	could	MD	MD	_	27	aux	_	_
27	block	block	VB	VB	_	22	ccomp	_	_
28	NF-kappaB-DNA	nf-kappab-dna	JJ	JJ	_	29	amod	_	_
29	binding	binding	NN	NN	_	27	dobj	_	_
30	by	by	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	redox	redox	NN	NN	_	33	compound	_	_
33	mechanism	mechanism	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	9	det	_	_
6	monovalent	monovalent	JJ	JJ	_	9	amod	_	_
7	gold	gold	NN	NN	_	9	compound	_	_
8	compound	compound	NN	NN	_	9	compound	_	_
9	AuTG	autg	NN	NN	_	14	nsubj	_	_
10	is	be	VBZ	VBZ	_	14	cop	_	_
11	a	a	DT	DT	_	14	det	_	_
12	potentially	potentially	RB	RB	_	13	advmod	_	_
13	useful	useful	JJ	JJ	_	14	amod	_	_
14	drug	drug	NN	NN	_	3	ccomp	_	_
15	for	for	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	treatment	treatment	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	patients	patient	NNS	NNS	_	17	nmod	_	_
20	infected	infect	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	HIV	hiv	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	4	case	_	_
3	suppressed	suppress	VBN	VBN	_	4	amod	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	NFAT1	nfat1	NN	NN	_	4	nmod	_	_
10	at	at	IN	IN	_	15	case	_	_
11	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
12	proximal	proximal	JJ	JJ	_	15	amod	_	_
13	binding	binding	NN	NN	_	15	compound	_	_
14	element	element	NN	NN	_	15	compound	_	_
15	P0	p0	NN	NN	_	4	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-4	il-4	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	associated	associate	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	25	case	_	_
22	enhanced	enhance	VBN	VBN	_	25	amod	_	_
23	IL-4	il-4	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	atopic	atopic	JJ	JJ	_	31	amod	_	_
31	patients	patient	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	Allergen-specific	allergen-specific	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	11	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	atopic	atopic	JJ	JJ	_	6	amod	_	_
6	patients	patient	NNS	NNS	_	3	nmod	_	_
7	are	be	VBP	VBP	_	11	cop	_	_
8	polarized	polarize	VBN	VBN	_	11	amod	_	_
9	IL-4-producing	il-4-producing	JJ	JJ	_	11	amod	_	_
10	Th2	th2	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	promoting	promote	VBG	VBG	_	11	advcl	_	_
14	IgE	ige	NN	NN	_	15	compound	_	_
15	synthesis	synthesis	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	18	case	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	14	nsubjpass	_	_
4	for	for	IN	IN	_	8	case	_	_
5	increased	increase	VBN	VBN	_	8	amod	_	_
6	IL-4	il-4	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	3	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	atopy	atopy	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	14	auxpass	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	fully	fully	RB	RB	_	14	advmod	_	_
14	understood	understand	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	IL-4	il-4	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	regulation	regulation	NN	NN	_	6	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	general	general	JJ	JJ	_	6	nmod	_	_
6	involves	involve	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	17	det	_	_
8	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
9	factor	factor	NN	NN	_	17	compound	_	_
10	of	of	IN	IN	_	17	amod	_	_
11	activated	activate	VBN	VBN	_	17	amod	_	_
12	T	t	NN	NN	_	17	compound	_	_
13	cells	cell	NNS	NNS	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	NFAT	nfat	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	family	family	NN	NN	_	6	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcription	transcription	NN	NN	_	20	compound	_	_
20	factors	factor	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	of	of	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	29	nmod	_	_
24	NFAT1	nfat1	NN	NN	_	29	nsubj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	NFAT2	nfat2	NN	NN	_	24	conj	_	_
27	are	be	VBP	VBP	_	29	cop	_	_
28	most	most	RBS	RBS	_	29	advmod	_	_
29	prominent	prominent	JJ	JJ	_	20	acl:relcl	_	_
30	in	in	IN	IN	_	33	case	_	_
31	peripheral	peripheral	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Recently	recently	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	unique	unique	JJ	JJ	_	6	amod	_	_
5	inhibitory	inhibitory	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	14	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NFAT1	nfat1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	IL-4	il-4	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	control	control	NN	NN	_	6	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	shown	show	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mouse	mouse	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	series	series	NN	NN	_	25	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
6	mobility	mobility	NN	NN	_	8	compound	_	_
7	shift	shift	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	3	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	extracts	extract	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	highly	highly	RB	RB	_	16	advmod	_	_
14	polarized	polarize	VBN	VBN	_	16	amod	_	_
15	Th2	th2	NN	NN	_	16	compound	_	_
16	clones	clone	NNS	NNS	_	11	nmod	_	_
17	from	from	IN	IN	_	18	case	_	_
18	atopics	atopic	NNS	NNS	_	16	nmod	_	_
19	and	and	CC	CC	_	16	cc	_	_
20	Th1	th1	NN	NN	_	21	compound	_	_
21	clones	clone	NNS	NNS	_	16	conj	_	_
22	from	from	IN	IN	_	23	case	_	_
23	controls	control	NNS	NNS	_	21	nmod	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	compared	compare	VBD	VBD	_	0	root	_	_
26	DNA-binding	dna-binding	NN	NN	_	27	compound	_	_
27	activities	activity	NNS	NNS	_	25	dobj	_	_
28	at	at	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	two	two	CD	CD	_	32	nummod	_	_
31	NFAT-binding	nfat-binding	JJ	JJ	_	32	amod	_	_
32	elements	element	NNS	NNS	_	27	nmod	_	_
33	P0	p0	NN	NN	_	32	dep	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	P1	p1	NN	NN	_	33	conj	_	_
36	of	of	IN	IN	_	42	case	_	_
37	the	the	DT	DT	_	42	det	_	_
38	crucial	crucial	JJ	JJ	_	42	amod	_	_
39	proximal	proximal	JJ	JJ	_	42	amod	_	_
40	human	human	JJ	JJ	_	42	amod	_	_
41	IL-4	il-4	NN	NN	_	42	compound	_	_
42	promoter	promoter	NN	NN	_	32	nmod	_	_
43	.	.	.	.	_	25	punct	_	_

1	At	at	IN	IN	_	6	case	_	_
2	the	the	DT	DT	_	6	det	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	proximal	proximal	JJ	JJ	_	6	amod	_	_
5	P0	p0	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	15	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	NFAT-containing	nfat-containing	JJ	JJ	_	9	amod	_	_
9	complexes	complex	NNS	NNS	_	15	nsubj	_	_
10	devoid	devoid	JJ	JJ	_	9	amod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NFAT2	nfat2	NN	NN	_	10	nmod	_	_
13	were	be	VBD	VBD	_	15	cop	_	_
14	readily	readily	RB	RB	_	15	advmod	_	_
15	inducible	inducible	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Th1	th1	NN	NN	_	19	compound	_	_
19	clones	clone	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	but	but	CC	CC	_	15	cc	_	_
22	hardly	hardly	RB	RB	_	23	advmod	_	_
23	or	or	CC	CC	_	15	conj	_	_
24	not	not	RB	RB	_	23	advmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	Th2	th2	NN	NN	_	28	compound	_	_
28	clones	clone	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	both	both	CC	CC	_	14	nmod	_	_
5	in	in	IN	IN	_	4	case	_	_
6	Th1	th1	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Th2	th2	NN	NN	_	6	conj	_	_
9	clones	clone	NNS	NNS	_	4	dep	_	_
10	NFAT-containing	nfat-containing	JJ	JJ	_	11	amod	_	_
11	complexes	complex	NNS	NNS	_	14	nsubj	_	_
12	were	be	VBD	VBD	_	14	cop	_	_
13	strongly	strongly	RB	RB	_	14	advmod	_	_
14	inducible	inducible	JJ	JJ	_	0	root	_	_
15	at	at	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	P1	p1	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	14	punct	_	_
20	consisting	consist	VBG	VBG	_	14	xcomp	_	_
21	of	of	IN	IN	_	22	case	_	_
22	NFAT2	nfat2	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	a	a	DT	DT	_	27	det	_	_
25	P0-compatible	p0-compatible	JJ	JJ	_	27	amod	_	_
26	NFAT	nfat	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	22	conj	_	_
28	,	,	,	,	_	14	punct	_	_
29	without	without	IN	IN	_	31	case	_	_
30	apparent	apparent	JJ	JJ	_	31	amod	_	_
31	differences	difference	NNS	NNS	_	14	nmod	_	_
32	between	between	IN	IN	_	36	case	_	_
33	Th1	th1	NN	NN	_	36	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	Th2	th2	NN	NN	_	33	conj	_	_
36	clones	clone	NNS	NNS	_	31	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	Like	like	IN	IN	_	4	case	_	_
2	in	in	IN	IN	_	4	case	_	_
3	Th2	th2	NN	NN	_	4	compound	_	_
4	clones	clone	NNS	NNS	_	11	advcl	_	_
5	,	,	,	,	_	11	punct	_	_
6	suppressed	suppress	VBN	VBN	_	9	amod	_	_
7	NFAT-P0	nfat-p0	NN	NN	_	9	compound	_	_
8	complex	complex	NN	NN	_	9	compound	_	_
9	formation	formation	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	also	also	RB	RB	_	16	advmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	polyclonal	polyclonal	JJ	JJ	_	16	amod	_	_
16	level	level	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
19	blood	blood	NN	NN	_	21	compound	_	_
20	mononuclear	mononuclear	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	11	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	PBMC	pbmc	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	of	of	IN	IN	_	32	case	_	_
26	three	three	CD	CD	_	28	compound	_	_
27	of	of	IN	IN	_	28	advmod	_	_
28	five	five	CD	CD	_	32	nummod	_	_
29	severe	severe	JJ	JJ	_	32	amod	_	_
30	atopic	atopic	JJ	JJ	_	32	amod	_	_
31	dermatitis	dermatitis	NN	NN	_	32	compound	_	_
32	patients	patient	NNS	NNS	_	21	nmod	_	_
33	with	with	IN	IN	_	38	case	_	_
34	strongly	strongly	RB	RB	_	35	advmod	_	_
35	elevated	elevated	JJ	JJ	_	38	amod	_	_
36	serum	serum	NN	NN	_	38	compound	_	_
37	IgE	ige	NN	NN	_	38	compound	_	_
38	levels	level	NNS	NNS	_	32	nmod	_	_
39	,	,	,	,	_	21	punct	_	_
40	but	but	CC	CC	_	41	cc	_	_
41	not	not	RB	RB	_	21	cc	_	_
42	in	in	IN	IN	_	44	case	_	_
43	control	control	JJ	JJ	_	44	amod	_	_
44	PBMC	pbmc	NN	NN	_	21	conj	_	_
45	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	high-level	high-level	JJ	JJ	_	7	amod	_	_
6	IL-4	il-4	NN	NN	_	7	compound	_	_
7	production	production	NN	NN	_	13	nsubjpass	_	_
8	in	in	IN	IN	_	11	case	_	_
9	atopic	atopic	JJ	JJ	_	11	amod	_	_
10	Th2	th2	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	3	ccomp	_	_
14	with	with	IN	IN	_	16	case	_	_
15	selective	selective	JJ	JJ	_	16	amod	_	_
16	reduction	reduction	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	suppressive	suppressive	JJ	JJ	_	20	amod	_	_
19	NFAT1	nfat1	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	16	nmod	_	_
21	at	at	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	IL-4	il-4	NN	NN	_	25	compound	_	_
24	P0	p0	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	16	nmod	_	_
26	and	and	CC	CC	_	13	cc	_	_
27	that	that	IN	IN	_	35	mark	_	_
28	some	some	DT	DT	_	29	det	_	_
29	patients	patient	NNS	NNS	_	35	nsubj	_	_
30	with	with	IN	IN	_	33	case	_	_
31	this	this	DT	DT	_	33	det	_	_
32	multifactorial	multifactorial	JJ	JJ	_	33	amod	_	_
33	disease	disease	NN	NN	_	29	nmod	_	_
34	may	may	MD	MD	_	35	aux	_	_
35	have	have	VB	VB	_	13	conj	_	_
36	a	a	DT	DT	_	39	det	_	_
37	putative	putative	JJ	JJ	_	39	amod	_	_
38	systemic	systemic	JJ	JJ	_	39	amod	_	_
39	disorder	disorder	NN	NN	_	35	dobj	_	_
40	at	at	IN	IN	_	42	case	_	_
41	this	this	DT	DT	_	42	det	_	_
42	level	level	NN	NN	_	35	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	factor-kappa	factor-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	rheumatic	rheumatic	JJ	JJ	_	12	amod	_	_
12	diseases	disease	NNS	NNS	_	9	nmod	_	_
13	:	:	:	:	_	4	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	preliminary	preliminary	JJ	JJ	_	16	amod	_	_
16	report	report	NN	NN	_	4	dep	_	_
17	.	.	.	.	_	4	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B/Rel	b/rel	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	6	nmod	_	_
10	regulates	regulate	VBZ	VBZ	_	1	appos	_	_
11	the	the	DT	DT	_	12	det	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	many	many	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	involved	involve	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	immune	immune	JJ	JJ	_	22	amod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	inflammatory	inflammatory	JJ	JJ	_	19	conj	_	_
22	response	response	NN	NN	_	16	nmod	_	_
23	at	at	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	level	level	NN	NN	_	12	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	17	mark	_	_
10	distinctive	distinctive	JJ	JJ	_	11	amod	_	_
11	patterns	pattern	NNS	NNS	_	17	nsubjpass	_	_
12	of	of	IN	IN	_	15	case	_	_
13	NF-kappa	nf-kappa	NN	NN	_	15	compound	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	seen	see	VBN	VBN	_	8	ccomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	different	different	JJ	JJ	_	20	amod	_	_
20	forms	form	NNS	NNS	_	17	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	joint	joint	NN	NN	_	23	compound	_	_
23	disease	disease	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	nucleoproteins	nucleoprotein	NNS	NNS	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	examined	examine	VBN	VBN	_	1	appos	_	_
12	in	in	IN	IN	_	18	case	_	_
13	purified	purify	VBN	VBN	_	18	amod	_	_
14	synovial	synovial	JJ	JJ	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	peripheral	peripheral	JJ	JJ	_	14	conj	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	11	nmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	18	nmod	_	_
21	with	with	IN	IN	_	25	case	_	_
22	various	various	JJ	JJ	_	25	amod	_	_
23	chronic	chronic	JJ	JJ	_	25	amod	_	_
24	rheumatic	rheumatic	JJ	JJ	_	25	amod	_	_
25	diseases	disease	NNS	NNS	_	20	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	12	12	CD	CD	_	20	dep	_	_
28	:	:	:	:	_	27	punct	_	_
29	four	four	CD	CD	_	27	dep	_	_
30	with	with	IN	IN	_	32	case	_	_
31	rheumatoid	rheumatoid	JJ	JJ	_	32	amod	_	_
32	arthritis	arthritis	NN	NN	_	29	nmod	_	_
33	;	;	:	:	_	29	punct	_	_
34	five	five	CD	CD	_	29	conj	_	_
35	with	with	IN	IN	_	36	case	_	_
36	spondyloarthropathies	spondyloarthropathy	NNS	NNS	_	34	nmod	_	_
37	;	;	:	:	_	29	punct	_	_
38	and	and	CC	CC	_	29	cc	_	_
39	three	three	CD	CD	_	29	conj	_	_
40	with	with	IN	IN	_	41	case	_	_
41	osteoarthritis	osteoarthritis	NN	NN	_	39	nmod	_	_
42	)	)	-RRB-	-RRB-	_	27	punct	_	_
43	.	.	.	.	_	1	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Electrophoretic	electrophoretic	JJ	JJ	_	6	amod	_	_
4	mobility	mobility	NN	NN	_	6	compound	_	_
5	shift	shift	NN	NN	_	6	compound	_	_
6	assays	assay	NNS	NNS	_	7	nsubj	_	_
7	disclosed	disclose	VBD	VBD	_	1	appos	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	7	dobj	_	_
11	bound	bind	VBN	VBN	_	10	acl	_	_
12	to	to	TO	TO	_	18	case	_	_
13	a	a	DT	DT	_	18	det	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	nmod:npmod	_	_
15	B	b	NN	NN	_	16	nmod:npmod	_	_
16	specific	specific	JJ	JJ	_	18	amod	_	_
17	32P-labelled	32p-labelled	JJ	JJ	_	18	amod	_	_
18	oligonucleotide	oligonucleotide	NN	NN	_	11	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	nucleoproteins	nucleoprotein	NNS	NNS	_	10	nmod	_	_
21	extracted	extract	VBN	VBN	_	20	acl	_	_
22	from	from	IN	IN	_	25	case	_	_
23	purified	purify	VBN	VBN	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	isolated	isolate	VBN	VBN	_	25	acl	_	_
27	from	from	IN	IN	_	29	case	_	_
28	synovial	synovial	JJ	JJ	_	29	amod	_	_
29	fluid	fluid	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
32	blood	blood	NN	NN	_	29	conj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	patients	patient	NNS	NNS	_	32	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	rheumatoid	rheumatoid	JJ	JJ	_	37	amod	_	_
37	arthritis	arthritis	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	complexes	complex	NNS	NNS	_	3	nsubj	_	_
3	consisted	consist	VBD	VBD	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	p50/p50	p50/p50	NN	NN	_	6	compound	_	_
6	homodimers	homodimer	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p50/p65	p50/p65	NN	NN	_	9	compound	_	_
9	heterodimers	heterodimer	NNS	NNS	_	6	conj	_	_
10	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	12	nsubjpass	_	_
5	to	to	TO	TO	_	6	case	_	_
6	DNA	dna	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	synovial	synovial	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	relative	relative	JJ	JJ	_	17	case	_	_
14	to	to	TO	TO	_	17	case	_	_
15	peripheral	peripheral	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	non-rheumatoid	non-rheumatoid	JJ	JJ	_	3	amod	_	_
3	arthritis	arthritis	NN	NN	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	binding	binding	NN	NN	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
8	B	b	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	synovial	synovial	JJ	JJ	_	12	amod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	exclusively	exclusively	RB	RB	_	15	advmod	_	_
15	mediated	mediate	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	p50/p50	p50/p50	NN	NN	_	18	compound	_	_
18	homodimers	homodimer	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Overall	overall	RB	RB	_	7	advmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	results	result	NNS	NNS	_	7	nsubj	_	_
7	suggest	suggest	VBP	VBP	_	1	appos	_	_
8	that	that	IN	IN	_	12	mark	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	play	play	VB	VB	_	7	ccomp	_	_
13	a	a	DT	DT	_	15	det	_	_
14	central	central	JJ	JJ	_	15	amod	_	_
15	part	part	NN	NN	_	12	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activation	activation	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	infiltrating	infiltrate	VBG	VBG	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	chronic	chronic	JJ	JJ	_	26	amod	_	_
25	rheumatoid	rheumatoid	JJ	JJ	_	26	amod	_	_
26	arthritis	arthritis	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	qualitatively	qualitatively	RB	RB	_	9	advmod	_	_
9	different	different	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	14	case	_	_
11	rheumatoid	rheumatoid	JJ	JJ	_	14	amod	_	_
12	synovial	synovial	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	that	that	DT	DT	_	9	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	other	other	JJ	JJ	_	19	amod	_	_
19	forms	form	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	non-rheumatoid	non-rheumatoid	JJ	JJ	_	22	amod	_	_
22	arthritis	arthritis	NN	NN	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	19	punct	_	_
24	for	for	IN	IN	_	27	case	_	_
25	example	example	NN	NN	_	27	dep	_	_
26	,	,	,	,	_	27	punct	_	_
27	osteoarthritis	osteoarthritis	NN	NN	_	19	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	spondyloarthropathies	spondyloarthropathy	NNS	NNS	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	19	punct	_	_
31	.	.	.	.	_	9	punct	_	_

1	High	high	JJ	JJ	_	2	amod	_	_
2	frequency	frequency	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	germ-line	germ-line	NN	NN	_	6	compound	_	_
5	BRCA2	brca2	NN	NN	_	6	compound	_	_
6	mutations	mutation	NNS	NNS	_	2	nmod	_	_
7	among	among	IN	IN	_	12	case	_	_
8	Hungarian	hungarian	JJ	JJ	_	12	amod	_	_
9	male	male	JJ	JJ	_	12	amod	_	_
10	breast	breast	NN	NN	_	12	compound	_	_
11	cancer	cancer	NN	NN	_	12	compound	_	_
12	patients	patient	NNS	NNS	_	2	nmod	_	_
13	without	without	IN	IN	_	15	case	_	_
14	family	family	NN	NN	_	15	compound	_	_
15	history	history	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	48	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	contribution	contribution	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	BRCA1	brca1	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	BRCA2	brca2	NN	NN	_	6	conj	_	_
9	mutations	mutation	NNS	NNS	_	4	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	pathogenesis	pathogenesis	NN	NN	_	4	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	male	male	JJ	JJ	_	16	amod	_	_
15	breast	breast	NN	NN	_	16	compound	_	_
16	cancer	cancer	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	Hungary	Hungary	NNP	NNP	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	the	the	DT	DT	_	21	det	_	_
21	country	country	NN	NN	_	18	appos	_	_
22	with	with	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	highest	highest	JJS	JJS	_	29	amod	_	_
25	male	male	JJ	JJ	_	29	amod	_	_
26	breast	breast	NN	NN	_	29	compound	_	_
27	cancer	cancer	NN	NN	_	29	compound	_	_
28	mortality	mortality	NN	NN	_	29	compound	_	_
29	rates	rate	NNS	NNS	_	21	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	continental	continental	JJ	JJ	_	32	amod	_	_
32	Europe	europe	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	48	punct	_	_
34	a	a	DT	DT	_	35	det	_	_
35	series	series	NN	NN	_	48	nsubjpass	_	_
36	of	of	IN	IN	_	41	case	_	_
37	18	18	CD	CD	_	41	nummod	_	_
38	male	male	JJ	JJ	_	41	amod	_	_
39	breast	breast	NN	NN	_	41	compound	_	_
40	cancer	cancer	NN	NN	_	41	compound	_	_
41	patients	patient	NNS	NNS	_	35	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	three	three	CD	CD	_	44	nummod	_	_
44	patients	patient	NNS	NNS	_	41	conj	_	_
45	with	with	IN	IN	_	46	case	_	_
46	gynecomastia	gynecomastia	NN	NN	_	44	nmod	_	_
47	was	be	VBD	VBD	_	48	auxpass	_	_
48	analyzed	analyze	VBN	VBN	_	0	root	_	_
49	for	for	IN	IN	_	51	case	_	_
50	germ-line	germ-line	NN	NN	_	51	compound	_	_
51	mutations	mutation	NNS	NNS	_	48	nmod	_	_
52	in	in	IN	IN	_	54	case	_	_
53	both	both	CC	CC	_	54	cc:preconj	_	_
54	BRCA1	brca1	NN	NN	_	51	nmod	_	_
55	and	and	CC	CC	_	54	cc	_	_
56	BRCA2	brca2	NN	NN	_	54	conj	_	_
57	.	.	.	.	_	48	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	no	no	DT	DT	_	5	neg	_	_
3	germ-line	germ-line	NN	NN	_	5	compound	_	_
4	BRCA1	brca1	NN	NN	_	5	compound	_	_
5	mutation	mutation	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	21	advcl	_	_
8	,	,	,	,	_	21	punct	_	_
9	6	6	CD	CD	_	21	nsubj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	18	18	CD	CD	_	16	nummod	_	_
13	male	male	JJ	JJ	_	16	amod	_	_
14	breast	breast	NN	NN	_	16	compound	_	_
15	cancer	cancer	NN	NN	_	16	compound	_	_
16	cases	case	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	33	33	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	9	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	carried	carry	VBD	VBD	_	0	root	_	_
22	truncating	truncating	JJ	JJ	_	23	amod	_	_
23	mutations	mutation	NNS	NNS	_	21	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	BRCA2	brca2	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	21	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	none	none	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	them	they	PRP	PRP	_	3	nmod	_	_
6	reported	report	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	family	family	NN	NN	_	9	compound	_	_
9	history	history	NN	NN	_	6	dobj	_	_
10	for	for	IN	IN	_	12	case	_	_
11	breast/ovarian	breast/ovarian	JJ	JJ	_	12	amod	_	_
12	cancer	cancer	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Four	four	CD	CD	_	3	compound	_	_
2	of	of	IN	IN	_	3	advmod	_	_
3	six	six	CD	CD	_	5	nummod	_	_
4	truncating	truncating	JJ	JJ	_	5	amod	_	_
5	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	novel	novel	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	mutations	mutation	NNS	NNS	_	13	nsubj	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	recurrent	recurrent	JJ	JJ	_	7	conj	_	_
14	.	.	.	.	_	7	punct	_	_

1	Four	four	CD	CD	_	2	nummod	_	_
2	patients	patient	NNS	NNS	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	5	punct	_	_
4	22	22	CD	CD	_	5	nummod	_	_
5	%	%	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	had	have	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	history	history	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	breast/ovarian	breast/ovarian	JJ	JJ	_	13	amod	_	_
13	cancer	cancer	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	21	case	_	_
15	at	at	IN	IN	_	16	case	_	_
16	least	least	JJS	JJS	_	17	nmod:npmod	_	_
17	one	one	CD	CD	_	21	nummod	_	_
18	first-	first-	JJ	JJ	_	21	amod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	second-degree	second-degree	JJ	JJ	_	18	conj	_	_
21	relative	relative	JJ	JJ	_	7	nmod	_	_
22	;	;	:	:	_	7	punct	_	_
23	however	however	RB	RB	_	7	advmod	_	_
24	,	,	,	,	_	7	punct	_	_
25	no	no	DT	DT	_	27	neg	_	_
26	BRCA2	brca2	NN	NN	_	27	compound	_	_
27	mutation	mutation	NN	NN	_	29	nsubjpass	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	identified	identify	VBN	VBN	_	7	dep	_	_
30	among	among	IN	IN	_	31	case	_	_
31	them	they	PRP	PRP	_	29	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	mutation	mutation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	identified	identify	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	either	either	DT	DT	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	gynecomastias	gynecomastia	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	for	for	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	strong	strong	JJ	JJ	_	9	amod	_	_
8	genetic	genetic	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	male	male	JJ	JJ	_	13	amod	_	_
12	breast	breast	NN	NN	_	13	compound	_	_
13	cancer	cancer	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	Hungary	Hungary	NNP	NNP	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	RFX-B	rfx-b	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	the	the	DT	DT	_	4	det	_	_
4	gene	gene	NN	NN	_	0	root	_	_
5	responsible	responsible	JJ	JJ	_	4	amod	_	_
6	for	for	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	common	common	JJ	JJ	_	10	amod	_	_
10	cause	cause	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	bare	bare	JJ	JJ	_	15	amod	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	syndrome	syndrome	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	an	a	DT	DT	_	21	det	_	_
18	MHC	mhc	NN	NN	_	21	compound	_	_
19	class	class	NN	NN	_	21	compound	_	_
20	II	ii	CD	CD	_	21	nummod	_	_
21	immunodeficiency	immunodeficiency	NN	NN	_	15	appos	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	25	punct	_	_
23	published	publish	VBN	VBN	_	24	amod	_	_
24	erratum	erratum	NN	NN	_	25	nsubj	_	_
25	appears	appear	VBZ	VBZ	_	4	parataxis	_	_
26	in	in	IN	IN	_	27	case	_	_
27	Immunity	immunity	NN	NN	_	25	nmod	_	_
28	1999	1999	CD	CD	_	29	nummod	_	_
29	Mar	Mar	NNP	NNP	_	27	dep	_	_
30	;	;	:	:	_	27	punct	_	_
31	10	10	CD	CD	_	33	nummod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	3	3	CD	CD	_	27	dep	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	:	:	:	:	_	27	punct	_	_
36	399	399	CD	CD	_	27	dep	_	_
37	-RSB-	-rsb-	-RRB-	-RRB-	_	25	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	bare	bare	JJ	JJ	_	4	amod	_	_
3	lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
4	syndrome	syndrome	NN	NN	_	9	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	BLS	bls	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	characterized	characterize	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	absence	absence	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	MHC	mhc	NN	NN	_	17	compound	_	_
15	class	class	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	17	nummod	_	_
17	transcription	transcription	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	humoral-	humoral-	JJ	JJ	_	23	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	cellular-mediated	cellular-mediated	JJ	JJ	_	19	conj	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	responses	response	NNS	NNS	_	17	conj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	foreign	foreign	JJ	JJ	_	26	amod	_	_
26	antigens	antigen	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	Three	three	CD	CD	_	9	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	four	four	CD	CD	_	8	nummod	_	_
5	BLS	bls	NN	NN	_	8	compound	_	_
6	genetic	genetic	JJ	JJ	_	8	amod	_	_
7	complementation	complementation	NN	NN	_	8	compound	_	_
8	groups	group	NNS	NNS	_	1	nmod	_	_
9	have	have	VBP	VBP	_	0	root	_	_
10	defects	defect	NNS	NNS	_	9	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	MHC	mhc	NN	NN	_	21	compound	_	_
17	class	class	NN	NN	_	21	compound	_	_
18	II	ii	CD	CD	_	21	nummod	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	factor	factor	NN	NN	_	21	compound	_	_
21	RFX	rfx	NN	NN	_	13	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	purified	purify	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	RFX	rfx	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	sequenced	sequence	VBN	VBN	_	3	conj	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	three	three	CD	CD	_	11	nummod	_	_
11	subunits	subunit	NNS	NNS	_	8	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	sequence	sequence	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	smallest	smallest	JJS	JJS	_	6	amod	_	_
6	subunit	subunit	NN	NN	_	2	nmod	_	_
7	describes	describe	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	novel	novel	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	termed	term	VBN	VBN	_	10	acl	_	_
13	RFX-B	rfx-b	NN	NN	_	12	xcomp	_	_
14	.	.	.	.	_	7	punct	_	_

1	RFX-B	rfx-b	NN	NN	_	2	nsubj	_	_
2	complements	complement	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	7	det	_	_
4	predominant	predominant	JJ	JJ	_	7	amod	_	_
5	BLS	bls	NN	NN	_	7	compound	_	_
6	complementation	complementation	NN	NN	_	7	compound	_	_
7	group	group	NN	NN	_	2	dobj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	group	group	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	2	conj	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	cop	_	_
17	mutant	mutant	JJ	JJ	_	14	xcomp	_	_
18	in	in	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	17	nmod	_	_
21	from	from	IN	IN	_	24	case	_	_
22	this	this	DT	DT	_	24	det	_	_
23	BLS	bls	NN	NN	_	24	compound	_	_
24	group	group	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	protein	protein	NN	NN	_	3	nsubj	_	_
3	has	have	VBZ	VBZ	_	0	root	_	_
4	no	no	DT	DT	_	7	neg	_	_
5	known	known	JJ	JJ	_	7	amod	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	3	dobj	_	_
8	but	but	CC	CC	_	3	cc	_	_
9	does	do	VBZ	VBZ	_	10	aux	_	_
10	contain	contain	VB	VB	_	3	conj	_	_
11	three	three	CD	CD	_	13	nummod	_	_
12	ankyrin	ankyrin	NN	NN	_	13	compound	_	_
13	repeats	repeat	NNS	NNS	_	10	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	likely	likely	JJ	JJ	_	13	acl:relcl	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	cop	_	_
19	important	important	JJ	JJ	_	16	xcomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	protein-protein	protein-protein	JJ	JJ	_	22	amod	_	_
22	interactions	interaction	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Alternative	alternative	JJ	JJ	_	3	amod	_	_
2	polyadenylation	polyadenylation	NN	NN	_	3	compound	_	_
3	events	event	NNS	NNS	_	4	nsubj	_	_
4	contribute	contribute	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	induction	induction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NF-ATc	nf-atc	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	effector	effector	NN	NN	_	13	compound	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	NF-ATc	nf-atc	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	synthesized	synthesize	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	three	three	CD	CD	_	10	nummod	_	_
9	prominent	prominent	JJ	JJ	_	10	amod	_	_
10	isoforms	isoform	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	differ	differ	VBP	VBP	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	length	length	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
8	C	c	NN	NN	_	10	compound	_	_
9	terminal	terminal	JJ	JJ	_	10	amod	_	_
10	peptides	peptide	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	mode	mode	NN	NN	_	5	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	synthesis	synthesis	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Due	due	JJ	JJ	_	4	case	_	_
2	to	to	TO	TO	_	1	mwe	_	_
3	a	a	DT	DT	_	4	det	_	_
4	switch	switch	NN	NN	_	22	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	use	use	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	3'	3'	JJ	JJ	_	12	amod	_	_
11	polyA	polya	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	7	nmod	_	_
13	to	to	TO	TO	_	18	case	_	_
14	a	a	DT	DT	_	18	det	_	_
15	more	more	RBR	RBR	_	18	advmod	_	_
16	proximal	proximal	JJ	JJ	_	18	amod	_	_
17	polyA	polya	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	4	nmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	NF-ATc	nf-atc	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	22	nsubj	_	_
22	switches	switch	VBZ	VBZ	_	0	root	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	synthesis	synthesis	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	two	two	CD	CD	_	30	nummod	_	_
29	longer	longer	JJR	JJR	_	30	amod	_	_
30	isoforms	isoform	NNS	NNS	_	25	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	naive	naive	JJ	JJ	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	30	nmod	_	_
35	to	to	TO	TO	_	36	case	_	_
36	that	that	DT	DT	_	22	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	short	short	JJ	JJ	_	40	amod	_	_
39	isoform	isoform	NN	NN	_	40	compound	_	_
40	A	a	NN	NN	_	36	nmod	_	_
41	in	in	IN	IN	_	44	case	_	_
42	T	t	NN	NN	_	44	compound	_	_
43	effector	effector	NN	NN	_	44	compound	_	_
44	cells	cell	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	relative	relative	JJ	JJ	_	3	amod	_	_
3	low	low	JJ	JJ	_	5	amod	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	affinity	affinity	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	cleavage	cleavage	NN	NN	_	10	compound	_	_
8	stimulation	stimulation	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	CstF-64	cstf-64	NN	NN	_	5	nmod	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	proximal	proximal	JJ	JJ	_	15	amod	_	_
14	polyA	polya	NN	NN	_	15	compound	_	_
15	site	site	NN	NN	_	5	nmod	_	_
16	seems	seem	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	contribute	contribute	VB	VB	_	16	xcomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	neglect	neglect	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	naive	naive	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	alternative	alternative	JJ	JJ	_	4	amod	_	_
3	polyadenylation	polyadenylation	NN	NN	_	4	compound	_	_
4	events	event	NNS	NNS	_	5	nsubj	_	_
5	ensure	ensure	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	rapid	rapid	JJ	JJ	_	8	amod	_	_
8	accumulation	accumulation	NN	NN	_	14	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	high	high	JJ	JJ	_	11	amod	_	_
11	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-ATc	nf-atc	NN	NN	_	11	nmod	_	_
14	necessary	necessary	JJ	JJ	_	5	xcomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	exceed	exceed	VB	VB	_	14	xcomp	_	_
17	critical	critical	JJ	JJ	_	19	amod	_	_
18	threshold	threshold	JJ	JJ	_	19	amod	_	_
19	levels	level	NNS	NNS	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NF-ATc	nf-atc	NN	NN	_	19	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	induction	induction	NN	NN	_	19	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	effector	effector	NN	NN	_	28	compound	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	primary	primary	JJ	JJ	_	7	amod	_	_
4	human	human	JJ	JJ	_	7	amod	_	_
5	T	t	NN	NN	_	7	compound	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	responses	response	NNS	NNS	_	2	dobj	_	_
8	at	at	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	dendritic	dendritic	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	level	level	NN	NN	_	2	nmod	_	_
13	:	:	:	:	_	2	punct	_	_
14	association	association	NN	NN	_	2	dep	_	_
15	with	with	IN	IN	_	17	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	inhibition	inhibition	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	NAC	nac	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	antioxidant	antioxidant	JJ	JJ	_	8	amod	_	_
8	molecule	molecule	NN	NN	_	0	root	_	_
9	endowed	endowed	JJ	JJ	_	8	dep	_	_
10	with	with	IN	IN	_	12	case	_	_
11	immunomodulatory	immunomodulatory	JJ	JJ	_	12	amod	_	_
12	properties	property	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	17	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NAC	nac	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	induction	induction	NN	NN	_	10	compound	_	_
10	phase	phase	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	responses	response	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	we	we	PRP	PRP	_	17	nsubj	_	_
17	analyzed	analyze	VBD	VBD	_	0	root	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	action	action	NN	NN	_	17	dobj	_	_
20	on	on	IN	IN	_	23	case	_	_
21	human	human	JJ	JJ	_	23	amod	_	_
22	dendritic	dendritic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	DC	dc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	derived	derive	VBN	VBN	_	23	acl	_	_
28	from	from	IN	IN	_	30	case	_	_
29	adherent	adherent	JJ	JJ	_	30	amod	_	_
30	PBMC	pbmc	NN	NN	_	27	nmod	_	_
31	cultured	culture	VBN	VBN	_	30	acl	_	_
32	with	with	IN	IN	_	33	case	_	_
33	IL-4	il-4	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	36	amod	_	_
36	CSF	csf	NN	NN	_	33	conj	_	_
37	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	first	first	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	NAC	nac	NN	NN	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	3	ccomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	constitutive	constitutive	JJ	JJ	_	6	dobj	_	_
9	as	as	RB	RB	_	8	cc	_	_
10	well	well	RB	RB	_	9	mwe	_	_
11	as	as	IN	IN	_	9	mwe	_	_
12	the	the	DT	DT	_	13	det	_	_
13	LPS-induced	lps-induced	JJ	JJ	_	8	conj	_	_
14	activity	activity	NN	NN	_	8	dep	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	transcription	transcription	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	NAC	nac	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	shown	show	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	down-regulate	down-regulate	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	cytokines	cytokine	NNS	NNS	_	10	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	DC	dc	NN	NN	_	10	nmod	_	_
15	as	as	RB	RB	_	10	cc	_	_
16	well	well	RB	RB	_	15	mwe	_	_
17	as	as	IN	IN	_	15	mwe	_	_
18	their	they	PRP$	PRP$	_	20	nmod:poss	_	_
19	surface	surface	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	10	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	HLA-DR	hla-dr	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	CD86	cd86	NN	NN	_	22	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	B7-2	b7-2	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	22	punct	_	_
29	and	and	CC	CC	_	22	cc	_	_
30	CD40	cd40	NN	NN	_	31	compound	_	_
31	molecules	molecule	NNS	NNS	_	22	conj	_	_
32	both	both	CC	CC	_	36	cc:preconj	_	_
33	at	at	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	basal	basal	JJ	JJ	_	36	amod	_	_
36	state	state	NN	NN	_	8	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	upon	upon	IN	IN	_	40	case	_	_
39	LPS	lps	NN	NN	_	40	compound	_	_
40	activation	activation	NN	NN	_	36	conj	_	_
41	.	.	.	.	_	6	punct	_	_

1	NAC	nac	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	DC	dc	NN	NN	_	5	compound	_	_
5	responses	response	NNS	NNS	_	3	dobj	_	_
6	induced	induce	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	9	case	_	_
8	CD40	cd40	NN	NN	_	9	compound	_	_
9	engagement	engagement	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NAC	nac	NN	NN	_	3	nmod	_	_
6	were	be	VBD	VBD	_	11	cop	_	_
7	not	not	RB	RB	_	11	neg	_	_
8	due	due	JJ	JJ	_	11	case	_	_
9	to	to	TO	TO	_	8	mwe	_	_
10	nonspecific	nonspecific	JJ	JJ	_	11	amod	_	_
11	toxicity	toxicity	NN	NN	_	0	root	_	_
12	as	as	IN	IN	_	24	mark	_	_
13	neither	neither	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	det	_	_
15	viability	viability	NN	NN	_	24	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	DC	dc	NN	NN	_	15	nmod	_	_
18	nor	nor	CC	CC	_	15	cc	_	_
19	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
20	mannose	mannose	NN	NN	_	21	nmod:npmod	_	_
21	receptor-mediated	receptor-mediated	JJ	JJ	_	22	amod	_	_
22	endocytosis	endocytosis	NN	NN	_	15	conj	_	_
23	were	be	VBD	VBD	_	24	auxpass	_	_
24	modified	modify	VBN	VBN	_	11	advcl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	NAC	nac	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	addition	addition	NN	NN	_	19	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	NAC	nac	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	case	_	_
11	MLR	mlr	NN	NN	_	7	nmod	_	_
12	between	between	IN	IN	_	15	case	_	_
13	naive	naive	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	allogeneic	allogeneic	JJ	JJ	_	18	amod	_	_
18	DC	dc	NN	NN	_	15	conj	_	_
19	resulted	result	VBD	VBD	_	4	ccomp	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	profound	profound	JJ	JJ	_	23	amod	_	_
23	inhibition	inhibition	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	alloreactive	alloreactive	JJ	JJ	_	26	amod	_	_
26	responses	response	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	23	punct	_	_
28	which	which	WDT	WDT	_	31	nsubjpass	_	_
29	could	could	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	attributed	attribute	VBN	VBN	_	23	acl:relcl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	defect	defect	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	DC	dc	NN	NN	_	34	nmod	_	_
37	as	as	IN	IN	_	44	mark	_	_
38	APC-independent	apc-independent	JJ	JJ	_	41	amod	_	_
39	T	t	NN	NN	_	41	compound	_	_
40	cell	cell	NN	NN	_	41	compound	_	_
41	responses	response	NNS	NNS	_	44	nsubjpass	_	_
42	were	be	VBD	VBD	_	44	auxpass	_	_
43	not	not	RB	RB	_	44	neg	_	_
44	inhibited	inhibit	VBN	VBN	_	19	advcl	_	_
45	by	by	IN	IN	_	46	case	_	_
46	NAC	nac	NN	NN	_	44	nmod	_	_
47	.	.	.	.	_	4	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	NAC	nac	NN	NN	_	9	nsubj	_	_
8	might	might	MD	MD	_	9	aux	_	_
9	impair	impair	VB	VB	_	5	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	generation	generation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	primary	primary	JJ	JJ	_	15	amod	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	responses	response	NNS	NNS	_	11	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	humans	human	NNS	NNS	_	11	nmod	_	_
18	through	through	IN	IN	_	21	case	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	inhibitory	inhibitory	JJ	JJ	_	21	amod	_	_
21	action	action	NN	NN	_	9	nmod	_	_
22	on	on	IN	IN	_	23	case	_	_
23	DC	dc	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	NF-ATc	nf-atc	NN	NN	_	2	compound	_	_
2	isoforms	isoform	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	aux	_	_
4	differentially	differentially	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	regulated	regulate	VBN	VBN	_	5	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	murine	murine	JJ	JJ	_	10	amod	_	_
10	T	t	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	mast	mast	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	NF	nf	NN	NN	_	5	compound	_	_
2	of	of	IN	IN	_	5	amod	_	_
3	activated	activate	VBN	VBN	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	NF-AT	nf-at	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	denotes	denote	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	11	det	_	_
11	family	family	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	regulate	regulate	VBP	VBP	_	14	acl:relcl	_	_
17	the	the	DT	DT	_	19	det	_	_
18	activation-dependent	activation-dependent	JJ	JJ	_	19	amod	_	_
19	expression	expression	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	24	case	_	_
21	many	many	JJ	JJ	_	24	amod	_	_
22	immunologically	immunologically	RB	RB	_	24	advmod	_	_
23	important	important	JJ	JJ	_	24	amod	_	_
24	proteins	protein	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	nmod:npmod	_	_
3	four	four	CD	CD	_	5	nummod	_	_
4	distinct	distinct	JJ	JJ	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	6	nsubj	_	_
6	encode	encode	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	10	det	_	_
8	various	various	JJ	JJ	_	10	amod	_	_
9	family	family	NN	NN	_	10	compound	_	_
10	members	member	NNS	NNS	_	6	dobj	_	_
11	,	,	,	,	_	6	punct	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	several	several	JJ	JJ	_	14	amod	_	_
14	isoforms	isoform	NNS	NNS	_	19	nsubjpass	_	_
15	of	of	IN	IN	_	16	case	_	_
16	these	these	DT	DT	_	14	nmod	_	_
17	have	have	VBP	VBP	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	identified	identify	VBN	VBN	_	6	conj	_	_
20	as	as	RB	RB	_	19	advmod	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	overlapping	overlap	VBG	VBG	_	4	amod	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	patterns	pattern	NNS	NNS	_	20	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	similar	similar	JJ	JJ	_	9	amod	_	_
7	in	in	FW	FW	_	9	amod	_	_
8	vitro	vitro	FW	FW	_	7	dep	_	_
9	binding	binding	NN	NN	_	4	conj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	trans-activation	trans-activation	JJ	JJ	_	12	amod	_	_
12	activities	activity	NNS	NNS	_	9	conj	_	_
13	on	on	IN	IN	_	16	case	_	_
14	various	various	JJ	JJ	_	16	amod	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	elements	element	NNS	NNS	_	4	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-AT-regulated	nf-at-regulated	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	16	nmod	_	_
20	suggest	suggest	VBP	VBP	_	0	root	_	_
21	some	some	DT	DT	_	22	det	_	_
22	redundancy	redundancy	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	function	function	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	proteins	protein	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	phenotypic	phenotypic	JJ	JJ	_	5	amod	_	_
5	analysis	analysis	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-AT-deficient	nf-at-deficient	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	5	nmod	_	_
9	supports	support	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	idea	idea	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	14	mark	_	_
13	there	there	EX	EX	_	14	expl	_	_
14	are	be	VBP	VBP	_	11	ccomp	_	_
15	tissue-	tissue-	NN	NN	_	18	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	gene-specific	gene-specific	JJ	JJ	_	15	conj	_	_
18	functions	function	NNS	NNS	_	14	nsubj	_	_
19	as	as	RB	RB	_	14	advmod	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	characterized	characterize	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-AT	nf-at	NN	NN	_	11	compound	_	_
11	cDNAs	cdna	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	murine	murine	JJ	JJ	_	15	amod	_	_
14	mast	mast	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	majority	majority	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	clones	clone	NNS	NNS	_	2	nmod	_	_
5	identified	identify	VBN	VBN	_	4	acl	_	_
6	correspond	correspond	VBP	VBP	_	0	root	_	_
7	to	to	TO	TO	_	10	case	_	_
8	two	two	CD	CD	_	10	nummod	_	_
9	NF-ATc	nf-atc	NN	NN	_	10	compound	_	_
10	isoforms	isoform	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	differ	differ	VBP	VBP	_	10	acl:relcl	_	_
13	only	only	RB	RB	_	17	advmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	amino-terminal	amino-terminal	JJ	JJ	_	17	amod	_	_
17	sequence	sequence	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	minimal	minimal	JJ	JJ	_	3	amod	_	_
3	discrepancies	discrepancy	NNS	NNS	_	10	nmod	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	coding	code	VBG	VBG	_	7	amod	_	_
7	region	region	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	there	there	EX	EX	_	10	expl	_	_
10	are	be	VBP	VBP	_	0	root	_	_
11	striking	striking	JJ	JJ	_	16	amod	_	_
12	tissue-	tissue-	NN	NN	_	16	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	cell	cell	NN	NN	_	15	nmod:npmod	_	_
15	type-specific	type-specific	JJ	JJ	_	12	conj	_	_
16	differences	difference	NNS	NNS	_	10	nsubj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	isoform	isoform	NN	NN	_	20	compound	_	_
19	expression	expression	NN	NN	_	20	compound	_	_
20	patterns	pattern	NNS	NNS	_	10	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	Detection	detection	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-ATc.alpha	nf-atc.alpha	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	strictly	strictly	RB	RB	_	7	advmod	_	_
7	dependent	dependent	JJ	JJ	_	0	root	_	_
8	on	on	IN	IN	_	11	case	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	activation	activation	NN	NN	_	11	compound	_	_
11	signals	signal	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	T	t	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	mast	mast	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	conj	_	_
19	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	beta	beta	NN	NN	_	6	compound	_	_
6	isoform	isoform	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	0	root	_	_
9	at	at	IN	IN	_	13	case	_	_
10	very	very	RB	RB	_	11	advmod	_	_
11	low	low	JJ	JJ	_	13	amod	_	_
12	constitutive	constitutive	JJ	JJ	_	13	amod	_	_
13	levels	level	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	both	both	DT	DT	_	17	det	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	types	type	NNS	NNS	_	8	nmod	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	is	be	VBZ	VBZ	_	21	auxpass	_	_
20	only	only	RB	RB	_	21	advmod	_	_
21	up-regulated	up-regulate	VBN	VBN	_	8	conj	_	_
22	in	in	IN	IN	_	28	case	_	_
23	response	response	NN	NN	_	28	dep	_	_
24	to	to	TO	TO	_	28	case	_	_
25	mast	mast	NN	NN	_	28	compound	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	activation	activation	NN	NN	_	28	compound	_	_
28	signals	signal	NNS	NNS	_	21	nmod	_	_
29	delivered	deliver	VBN	VBN	_	28	acl	_	_
30	through	through	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	FcepsilonRI	fcepsilonri	NN	NN	_	29	nmod	_	_
33	or	or	CC	CC	_	32	cc	_	_
34	via	via	IN	IN	_	36	case	_	_
35	calcium	calcium	NN	NN	_	36	compound	_	_
36	ionophores	ionophore	NNS	NNS	_	32	conj	_	_
37	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	another	another	DT	DT	_	5	det	_	_
5	level	level	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	regulation	regulation	NN	NN	_	5	nmod	_	_
8	within	within	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	NF-AT	nf-at	NN	NN	_	11	compound	_	_
11	family	family	NN	NN	_	5	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	contribute	contribute	VB	VB	_	5	acl:relcl	_	_
15	to	to	TO	TO	_	19	case	_	_
16	cell	cell	NN	NN	_	17	nmod:npmod	_	_
17	type-specific	type-specific	JJ	JJ	_	19	amod	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	direct	direct	JJ	JJ	_	3	amod	_	_
3	interaction	interaction	NN	NN	_	13	nsubj	_	_
4	between	between	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	adaptor	adaptor	NN	NN	_	8	compound	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	Cbl-b	cbl-b	NN	NN	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	zap-70	zap-70	NN	NN	_	8	conj	_	_
13	induces	induce	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	positive	positive	JJ	JJ	_	16	amod	_	_
16	signal	signal	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	13	punct	_	_

1	Engagement	engagement	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	T-cell	t-cell	NN	NN	_	10	compound	_	_
5	receptor	receptor	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	TCR	tcr	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	-CD3	-cd3	JJ	JJ	_	10	amod	_	_
10	complex	complex	NN	NN	_	1	nmod	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	rapid	rapid	JJ	JJ	_	14	amod	_	_
14	increase	increase	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	activities	activity	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	Src-family	src-family	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	Syk/Zap-70-family	syk/zap-70-family	NN	NN	_	19	conj	_	_
22	kinases	kinase	NNS	NNS	_	17	nmod	_	_
23	-LSB-	-lsb-	-LRB-	-LRB-	_	24	punct	_	_
24	1	1	CD	CD	_	11	dep	_	_
25	-RSB-	-rsb-	-RRB-	-RRB-	_	24	punct	_	_
26	-LSB-	-lsb-	-LRB-	-LRB-	_	27	punct	_	_
27	2	2	CD	CD	_	24	dep	_	_
28	-RSB-	-rsb-	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	activated	activate	VBN	VBN	_	3	amod	_	_
3	kinases	kinase	NNS	NNS	_	5	nsubj	_	_
4	then	then	RB	RB	_	5	advmod	_	_
5	induce	induce	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	multiple	multiple	JJ	JJ	_	12	amod	_	_
11	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
12	proteins	protein	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	eventually	eventually	RB	RB	_	15	advmod	_	_
15	leading	lead	VBG	VBG	_	5	advcl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	One	one	CD	CD	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	prominent	prominent	JJ	JJ	_	5	amod	_	_
5	substrates	substrate	NNS	NNS	_	1	nmod	_	_
6	for	for	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	kinases	kinase	NNS	NNS	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	the	the	DT	DT	_	13	det	_	_
11	adaptor	adaptor	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	Cbl	cbl	NN	NN	_	0	root	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	3	3	CD	CD	_	13	dep	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	recent	recent	JJ	JJ	_	19	amod	_	_
19	studies	study	NNS	NNS	_	20	nsubj	_	_
20	suggest	suggest	VBP	VBP	_	13	conj	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	Cbl	cbl	NN	NN	_	24	nsubj	_	_
23	negatively	negatively	RB	RB	_	24	advmod	_	_
24	regulates	regulate	VBZ	VBZ	_	20	ccomp	_	_
25	upstream	upstream	JJ	JJ	_	26	amod	_	_
26	kinases	kinase	NNS	NNS	_	24	dobj	_	_
27	such	such	JJ	JJ	_	29	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	Syk	syk	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	Zap-70	zap-70	NN	NN	_	29	conj	_	_
32	-LSB-	-lsb-	-LRB-	-LRB-	_	33	punct	_	_
33	4	4	CD	CD	_	24	dep	_	_
34	-RSB-	-rsb-	-RRB-	-RRB-	_	33	punct	_	_
35	-LSB-	-lsb-	-LRB-	-LRB-	_	36	punct	_	_
36	5	5	CD	CD	_	33	dep	_	_
37	-RSB-	-rsb-	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	13	punct	_	_

1	Cbl-b	cbl-b	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	homologue	homologue	NN	NN	_	1	appos	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Cbl	cbl	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	1	punct	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	widely	widely	RB	RB	_	10	advmod	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	many	many	JJ	JJ	_	13	amod	_	_
13	tissues	tissue	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	cells	cell	NNS	NNS	_	13	conj	_	_
16	including	include	VBG	VBG	_	18	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	-LSB-	-lsb-	-LRB-	-LRB-	_	20	punct	_	_
20	6	6	CD	CD	_	10	dep	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	20	punct	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
23	7	7	CD	CD	_	20	dep	_	_
24	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	10	punct	_	_

1	Cbl-b	cbl-b	NN	NN	_	2	nsubj	_	_
2	undergoes	undergo	VBZ	VBZ	_	0	root	_	_
3	rapid	rapid	JJ	JJ	_	5	amod	_	_
4	tyrosine	tyrosine	NN	NN	_	5	compound	_	_
5	phosphorylation	phosphorylation	NN	NN	_	2	dobj	_	_
6	upon	upon	IN	IN	_	7	case	_	_
7	stimulation	stimulation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	TCR	tcr	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	receptors	receptor	NNS	NNS	_	10	conj	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	8	8	CD	CD	_	2	dep	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	9	9	CD	CD	_	15	dep	_	_
19	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Cbl-b	cbl-b	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	unclear	unclear	JJ	JJ	_	0	root	_	_
7	,	,	,	,	_	6	punct	_	_
8	however	however	RB	RB	_	6	advmod	_	_
9	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	overexpression	overexpression	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Cbl-b	cbl-b	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	induced	induce	VBD	VBD	_	4	ccomp	_	_
13	the	the	DT	DT	_	15	det	_	_
14	constitutive	constitutive	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	25	case	_	_
17	the	the	DT	DT	_	25	det	_	_
18	transcription	transcription	NN	NN	_	25	compound	_	_
19	factor	factor	NN	NN	_	25	compound	_	_
20	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
21	factor	factor	NN	NN	_	25	compound	_	_
22	of	of	IN	IN	_	25	amod	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	15	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	NFAT	nfat	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	loss-of-function	loss-of-function	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	6	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	Cbl-b	cbl-b	NN	NN	_	3	nmod	_	_
6	disrupted	disrupt	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	6	dobj	_	_
9	between	between	IN	IN	_	10	case	_	_
10	Cbl-b	cbl-b	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Zap-70	zap-70	NN	NN	_	10	conj	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	nearly	nearly	RB	RB	_	15	advmod	_	_
15	completely	completely	RB	RB	_	16	advmod	_	_
16	abrogated	abrogate	VBD	VBD	_	6	conj	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Cbl-b-mediated	cbl-b-mediated	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	NFAT	nfat	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Unlike	unlike	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	proposed	proposed	JJ	JJ	_	4	amod	_	_
4	role	role	NN	NN	_	14	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Cbl	cbl	NN	NN	_	4	nmod	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	negative	negative	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	14	punct	_	_
12	our	we	PRP$	PRP$	_	13	nmod:poss	_	_
13	results	result	NNS	NNS	_	14	nsubj	_	_
14	suggest	suggest	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	20	mark	_	_
16	the	the	DT	DT	_	19	det	_	_
17	Cbl	cbl	NN	NN	_	19	compound	_	_
18	homologue	homologue	NN	NN	_	19	compound	_	_
19	Cbl-b	cbl-b	NN	NN	_	20	nsubj	_	_
20	has	have	VBZ	VBZ	_	14	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	positive	positive	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	T-cell	t-cell	NN	NN	_	26	compound	_	_
26	signaling	signaling	NN	NN	_	20	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	most	most	RBS	RBS	_	29	advmod	_	_
29	likely	likely	RB	RB	_	33	advmod	_	_
30	via	via	IN	IN	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	direct	direct	JJ	JJ	_	33	amod	_	_
33	interaction	interaction	NN	NN	_	20	nmod	_	_
34	with	with	IN	IN	_	38	case	_	_
35	the	the	DT	DT	_	38	det	_	_
36	upstream	upstream	JJ	JJ	_	38	amod	_	_
37	kinase	kinase	NN	NN	_	38	compound	_	_
38	Zap-70	zap-70	NN	NN	_	33	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	lipopolysaccharide	lipopolysaccharide	NN	NN	_	3	nsubj	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor-kappaB	factor-kappab	NN	NN	_	3	dobj	_	_
6	through	through	IN	IN	_	9	case	_	_
7	interleukin-1	interleukin-1	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	mediators	mediator	NNS	NNS	_	3	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	cultured	culture	VBN	VBN	_	15	amod	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	dermal	dermal	JJ	JJ	_	15	amod	_	_
14	endothelial	endothelial	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	3	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	phagocytes	phagocyte	NNS	NNS	_	15	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nmod:npmod	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	LPS	lps	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	-mediated	-mediated	JJ	JJ	_	8	amod	_	_
7	immune	immune	JJ	JJ	_	8	amod	_	_
8	responses	response	NNS	NNS	_	21	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	11	case	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	macrophages	macrophage	NNS	NNS	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	endothelial	endothelial	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	13	conj	_	_
20	,	,	,	,	_	8	punct	_	_
21	play	play	VBP	VBP	_	0	root	_	_
22	an	a	DT	DT	_	24	det	_	_
23	important	important	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	pathogenesis	pathogenesis	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	32	case	_	_
29	Gram-negative	gram-negative	JJ	JJ	_	32	amod	_	_
30	bacteria-induced	bacteria-induced	JJ	JJ	_	32	amod	_	_
31	sepsis	sepsis	NN	NN	_	32	compound	_	_
32	syndrome	syndrome	NN	NN	_	27	nmod	_	_
33	.	.	.	.	_	21	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	thought	think	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	5	xcomp	_	_
9	for	for	IN	IN	_	11	case	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	release	release	NN	NN	_	8	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	LPS-responsive	lps-responsive	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	critical	critical	JJ	JJ	_	18	amod	_	_
18	step	step	NN	NN	_	14	appos	_	_
19	for	for	IN	IN	_	21	case	_	_
20	endotoxic	endotoxic	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	involvement	involvement	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	22	case	_	_
9	interleukin-1	interleukin-1	NN	NN	_	22	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-1	il-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	and	and	CC	CC	_	22	cc	_	_
14	tumor	tumor	NN	NN	_	16	compound	_	_
15	necrosis	necrosis	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	22	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	signal	signal	NN	NN	_	22	compound	_	_
21	transducer	transducer	NN	NN	_	22	compound	_	_
22	molecules	molecule	NNS	NNS	_	5	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	LPS	lps	NN	NN	_	25	compound	_	_
25	signaling	signaling	NN	NN	_	5	nmod	_	_
26	in	in	IN	IN	_	31	case	_	_
27	human	human	JJ	JJ	_	31	amod	_	_
28	dermal	dermal	JJ	JJ	_	31	amod	_	_
29	microvessel	microvessel	NN	NN	_	31	compound	_	_
30	endothelial	endothelial	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	25	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	HDMEC	hdmec	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	THP-1	thp-1	NN	NN	_	38	compound	_	_
37	monocytic	monocytic	JJ	JJ	_	38	amod	_	_
38	cells	cell	NNS	NNS	_	31	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HDMEC	hdmec	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	THP-1	thp-1	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	conj	_	_
8	initiated	initiate	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	14	det	_	_
10	IL-1	il-1	NN	NN	_	11	nmod:npmod	_	_
11	receptor-like	receptor-like	JJ	JJ	_	14	amod	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	cascade	cascade	NN	NN	_	8	dobj	_	_
15	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	cotransfection	cotransfection	NN	NN	_	4	compound	_	_
4	experiments	experiment	NNS	NNS	_	24	nmod	_	_
5	,	,	,	,	_	24	punct	_	_
6	dominant	dominant	JJ	JJ	_	8	amod	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	mutants	mutant	NNS	NNS	_	24	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	IL-1	il-1	NN	NN	_	13	compound	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	including	include	VBG	VBG	_	16	case	_	_
16	MyD88	myd88	NN	NN	_	8	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	IRAK	irak	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	IRAK2	irak2	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	TRAF6	traf6	NN	NN	_	16	conj	_	_
24	inhibited	inhibit	VBD	VBD	_	0	root	_	_
25	both	both	CC	CC	_	26	cc:preconj	_	_
26	IL-1-	il-1-	NN	NN	_	30	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	LPS-induced	lps-induced	JJ	JJ	_	26	conj	_	_
29	NF-kappaB-luciferase	nf-kappab-luciferase	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	24	dobj	_	_
31	.	.	.	.	_	24	punct	_	_

1	LPS-induced	lps-induced	JJ	JJ	_	3	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	inhibited	inhibit	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	dominant	dominant	JJ	JJ	_	11	amod	_	_
10	negative	negative	JJ	JJ	_	11	amod	_	_
11	mutant	mutant	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	TRAF2	traf2	NN	NN	_	11	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	11	acl:relcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	TNF	tnf	NN	NN	_	19	compound	_	_
19	signaling	signaling	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	LPS-induced	lps-induced	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappaB-responsive	nf-kappab-responsive	JJ	JJ	_	6	amod	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	13	case	_	_
11	IL-1	il-1	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	antagonist	antagonist	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	TLR2	tlr2	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	TLR4	tlr4	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	surface	surface	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	HDMEC	hdmec	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	THP-1	thp-1	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	signal	signal	NN	NN	_	8	compound	_	_
7	transduction	transduction	NN	NN	_	8	compound	_	_
8	molecule	molecule	NN	NN	_	15	nsubj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	LPS	lps	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	8	nmod	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	belong	belong	VB	VB	_	3	ccomp	_	_
16	to	to	TO	TO	_	25	case	_	_
17	the	the	DT	DT	_	25	det	_	_
18	IL-1	il-1	NN	NN	_	25	compound	_	_
19	receptor/toll-like	receptor/toll-like	JJ	JJ	_	25	amod	_	_
20	receptor	receptor	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TLR	tlr	NN	NN	_	25	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	super	super	JJ	JJ	_	25	amod	_	_
25	family	family	NN	NN	_	15	nmod	_	_
26	,	,	,	,	_	15	punct	_	_
27	and	and	CC	CC	_	15	cc	_	_
28	the	the	DT	DT	_	31	det	_	_
29	LPS	lps	NN	NN	_	31	compound	_	_
30	signaling	signaling	NN	NN	_	31	compound	_	_
31	cascade	cascade	NN	NN	_	32	nsubj	_	_
32	uses	use	VBZ	VBZ	_	15	conj	_	_
33	an	a	DT	DT	_	36	det	_	_
34	analogous	analogous	JJ	JJ	_	36	amod	_	_
35	molecular	molecular	JJ	JJ	_	36	amod	_	_
36	framework	framework	NN	NN	_	32	dobj	_	_
37	for	for	IN	IN	_	38	case	_	_
38	signaling	signaling	NN	NN	_	36	nmod	_	_
39	as	as	IN	IN	_	40	case	_	_
40	IL-1	il-1	NN	NN	_	32	nmod	_	_
41	in	in	IN	IN	_	43	case	_	_
42	mononuclear	mononuclear	JJ	JJ	_	43	amod	_	_
43	phagocytes	phagocyte	NNS	NNS	_	32	nmod	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	endothelial	endothelial	JJ	JJ	_	46	amod	_	_
46	cells	cell	NNS	NNS	_	43	conj	_	_
47	.	.	.	.	_	3	punct	_	_

1	Detection	detection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
4	phosphorylated	phosphorylate	VBN	VBN	_	5	amod	_	_
5	STAT-1	stat-1	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	flow	flow	NN	NN	_	8	compound	_	_
8	cytometry	cytometry	NN	NN	_	1	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	applied	apply	VBN	VBN	_	0	root	_	_
4	flow	flow	NN	NN	_	5	compound	_	_
5	cytometry	cytometry	NN	NN	_	3	dobj	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	investigation	investigation	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	interferon-gamma	interferon-gamma	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	approach	approach	NN	NN	_	3	nsubj	_	_
3	uses	use	VBZ	VBZ	_	0	root	_	_
4	monoclonal	monoclonal	JJ	JJ	_	5	amod	_	_
5	antibodies	antibody	NNS	NNS	_	3	dobj	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	distinguish	distinguish	VBP	VBP	_	5	acl:relcl	_	_
8	between	between	IN	IN	_	13	case	_	_
9	the	the	DT	DT	_	13	det	_	_
10	native	native	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	phosphorylated	phosphorylated	JJ	JJ	_	10	conj	_	_
13	forms	form	NNS	NNS	_	7	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	STAT-1	stat-1	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	2	nsubj	_	_
2	enables	enable	VBZ	VBZ	_	0	root	_	_
3	rapid	rapid	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	quantitative	quantitative	JJ	JJ	_	3	conj	_	_
6	assessment	assessment	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	STAT-1	stat-1	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
10	on	on	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	discrete	discrete	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	basis	basis	NN	NN	_	2	nmod	_	_
15	and	and	CC	CC	_	2	cc	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	sensitive	sensitive	JJ	JJ	_	2	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	less	less	JJR	JJR	_	23	dep	_	_
22	time	time	NN	NN	_	23	nmod:npmod	_	_
23	consuming	consuming	JJ	JJ	_	19	conj	_	_
24	than	than	IN	IN	_	25	case	_	_
25	immunoblotting	immunoblotting	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	allows	allow	VBZ	VBZ	_	0	root	_	_
5	for	for	IN	IN	_	6	case	_	_
6	discrimination	discrimination	NN	NN	_	4	nmod	_	_
7	between	between	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	mixture	mixture	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	9	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	differ	differ	VBP	VBP	_	11	acl:relcl	_	_
14	in	in	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	response	response	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	interferon-gamma	interferon-gamma	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	approach	approach	NN	NN	_	4	nsubj	_	_
3	should	should	MD	MD	_	4	aux	_	_
4	allow	allow	VB	VB	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	evaluation	evaluation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	different	different	JJ	JJ	_	12	amod	_	_
10	intracellular	intracellular	JJ	JJ	_	12	amod	_	_
11	signaling	signaling	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	7	nmod	_	_
13	using	use	VBG	VBG	_	4	xcomp	_	_
14	a	a	DT	DT	_	15	det	_	_
15	combination	combination	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	monoclonal	monoclonal	JJ	JJ	_	18	amod	_	_
18	reagents	reagent	NNS	NNS	_	15	nmod	_	_
19	that	that	WDT	WDT	_	21	nsubj	_	_
20	are	be	VBP	VBP	_	21	cop	_	_
21	specific	specific	JJ	JJ	_	18	acl:relcl	_	_
22	for	for	IN	IN	_	27	case	_	_
23	native	native	JJ	JJ	_	27	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	activation	activation	NN	NN	_	26	nmod:npmod	_	_
26	modified	modified	JJ	JJ	_	23	conj	_	_
27	proteins	protein	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Application	application	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	form	form	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	testing	testing	NN	NN	_	4	nmod	_	_
7	should	should	MD	MD	_	8	aux	_	_
8	prove	prove	VB	VB	_	0	root	_	_
9	valuable	valuable	JJ	JJ	_	8	xcomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	screening	screen	VBG	VBG	_	8	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	signaling	signal	VBG	VBG	_	14	amod	_	_
14	defects	defect	NNS	NNS	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	selected	select	VBN	VBN	_	17	amod	_	_
17	patients	patient	NNS	NNS	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	recurrent	recurrent	JJ	JJ	_	20	amod	_	_
20	infections	infection	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	this	this	DT	DT	_	5	det	_	_
5	technique	technique	NN	NN	_	7	nsubj	_	_
6	should	should	MD	MD	_	7	aux	_	_
7	permit	permit	VB	VB	_	0	root	_	_
8	dissection	dissection	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	full	full	JJ	JJ	_	12	amod	_	_
12	range	range	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	cellular	cellular	JJ	JJ	_	16	amod	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	12	nmod	_	_
17	at	at	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	level	level	NN	NN	_	8	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	hormone	hormone	NN	NN	_	3	compound	_	_
3	suppression	suppression	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	neutrophil-mediated	neutrophil-mediated	JJ	JJ	_	9	amod	_	_
7	tumor	tumor	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	cytostasis	cytostasis	NN	NN	_	3	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effect	effect	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
13	hormones	hormone	NNS	NNS	_	10	nmod	_	_
14	on	on	IN	IN	_	18	case	_	_
15	neutrophil-mediated	neutrophil-mediated	JJ	JJ	_	18	amod	_	_
16	tumor	tumor	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	cytostasis	cytostasis	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	found	find	VBN	VBN	_	8	conj	_	_
21	that	that	IN	IN	_	33	mark	_	_
22	hydrocortisone	hydrocortisone	NN	NN	_	33	nsubj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	a	a	DT	DT	_	26	det	_	_
25	synthetic	synthetic	JJ	JJ	_	26	amod	_	_
26	hormone	hormone	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	dexamethasone	dexamethasone	NN	NN	_	26	appos	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	Dex	dex	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	26	punct	_	_
33	inhibited	inhibit	VBD	VBD	_	20	ccomp	_	_
34	cytostasis	cytostasis	NN	NN	_	33	dobj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	presence	presence	NN	NN	_	33	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	absence	absence	NN	NN	_	37	conj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	tumor	tumor	NN	NN	_	43	compound	_	_
42	necrosis	necrosis	NN	NN	_	43	compound	_	_
43	factor-alpha	factor-alpha	NN	NN	_	37	nmod	_	_
44	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Dex	dex	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	completely	completely	RB	RB	_	7	advmod	_	_
7	reversed	reverse	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	glucocorticoid	glucocorticoid	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	antagonist	antagonist	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	RU38486	ru38486	NN	NN	_	12	appos	_	_
15	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	clarify	clarify	VB	VB	_	8	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	underlying	underlying	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	examined	examine	VBD	VBD	_	0	root	_	_
9	effects	effect	NNS	NNS	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Dex	dex	NN	NN	_	9	nmod	_	_
12	on	on	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	binding	binding	NN	NN	_	15	compound	_	_
15	avidity	avidity	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	beta2	beta2	NN	NN	_	18	compound	_	_
18	integrin	integrin	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	neutrophil	neutrophil	NN	NN	_	22	compound	_	_
22	surface	surface	NN	NN	_	15	nmod	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	how	how	WRB	WRB	_	29	advmod	_	_
25	these	these	DT	DT	_	29	nsubj	_	_
26	might	might	MD	MD	_	29	aux	_	_
27	in	in	IN	IN	_	28	case	_	_
28	turn	turn	NN	NN	_	29	nmod	_	_
29	affect	affect	VB	VB	_	9	conj	_	_
30	neutrophil-to-tumor	neutrophil-to-tumor	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	binding	binding	NN	NN	_	29	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	Dex	dex	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	inhibit	inhibit	VB	VB	_	3	xcomp	_	_
6	these	these	DT	DT	_	8	det	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	properties	property	NNS	NNS	_	5	dobj	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	RU38486	ru38486	NN	NN	_	13	nsubj	_	_
12	completely	completely	RB	RB	_	13	advmod	_	_
13	suppressed	suppress	VBD	VBD	_	3	conj	_	_
14	both	both	DT	DT	_	15	det	_	_
15	forms	form	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	Dex	dex	NN	NN	_	18	compound	_	_
18	inhibition	inhibition	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	23	mark	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
9	hormone	hormone	NN	NN	_	10	compound	_	_
10	inhibition	inhibition	NN	NN	_	23	nsubj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	neutrophil-mediated	neutrophil-mediated	JJ	JJ	_	15	amod	_	_
13	tumor	tumor	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	cytostasis	cytostasis	NN	NN	_	10	nmod	_	_
16	is	be	VBZ	VBZ	_	23	cop	_	_
17	at	at	IN	IN	_	19	advmod	_	_
18	least	least	JJS	JJS	_	17	mwe	_	_
19	partially	partially	RB	RB	_	23	advmod	_	_
20	due	due	JJ	JJ	_	23	case	_	_
21	to	to	TO	TO	_	20	mwe	_	_
22	a	a	DT	DT	_	23	det	_	_
23	lowering	lowering	NN	NN	_	6	ccomp	_	_
24	of	of	IN	IN	_	28	case	_	_
25	the	the	DT	DT	_	28	det	_	_
26	ligand	ligand	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	avidity	avidity	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	beta2	beta2	NN	NN	_	31	compound	_	_
31	integrin	integrin	NN	NN	_	28	nmod	_	_
32	on	on	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	neutrophil	neutrophil	NN	NN	_	35	compound	_	_
35	surface	surface	NN	NN	_	28	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	Abnormalities	abnormality	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	cyclic	cyclic	JJ	JJ	_	6	amod	_	_
4	adenosine	adenosine	NN	NN	_	6	compound	_	_
5	monophosphate	monophosphate	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	platelets	platelet	NNS	NNS	_	6	nmod	_	_
9	from	from	IN	IN	_	11	case	_	_
10	untreated	untreated	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	with	with	IN	IN	_	14	case	_	_
13	bipolar	bipolar	JJ	JJ	_	14	amod	_	_
14	disorder	disorder	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Abnormalities	abnormality	NNS	NNS	_	18	nsubjpass	_	_
4	in	in	IN	IN	_	14	case	_	_
5	the	the	DT	DT	_	14	det	_	_
6	cyclic	cyclic	JJ	JJ	_	8	amod	_	_
7	adenosine	adenosine	NN	NN	_	8	compound	_	_
8	monophosphate	monophosphate	NN	NN	_	12	nmod:npmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	cAMP	camp	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	-dependent	-dependent	JJ	JJ	_	14	amod	_	_
13	phosphorylation	phosphorylation	NN	NN	_	14	compound	_	_
14	system	system	NN	NN	_	3	nmod	_	_
15	have	have	VBP	VBP	_	18	aux	_	_
16	been	be	VBN	VBN	_	18	auxpass	_	_
17	recently	recently	RB	RB	_	18	advmod	_	_
18	reported	report	VBN	VBN	_	1	appos	_	_
19	in	in	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	18	nmod	_	_
21	with	with	IN	IN	_	23	case	_	_
22	bipolar	bipolar	JJ	JJ	_	23	amod	_	_
23	disorder	disorder	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	immunoreactivity	immunoreactivity	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	catalytic	catalytic	JJ	JJ	_	7	conj	_	_
10	subunits	subunit	NNS	NNS	_	4	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	cAMP-dependent	camp-dependent	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	10	nmod	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	A	a	NN	NN	_	14	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	1	1	CD	CD	_	14	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	substrates	substrate	NNS	NNS	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	Rap1	rap1	NN	NN	_	21	appos	_	_
27	,	,	,	,	_	21	punct	_	_
28	in	in	IN	IN	_	29	case	_	_
29	platelets	platelet	NNS	NNS	_	10	nmod	_	_
30	from	from	IN	IN	_	38	case	_	_
31	untreated	untreated	JJ	JJ	_	38	amod	_	_
32	euthymic	euthymic	JJ	JJ	_	38	amod	_	_
33	,	,	,	,	_	32	punct	_	_
34	manic	manic	JJ	JJ	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	depressed	depressed	JJ	JJ	_	32	conj	_	_
38	patients	patient	NNS	NNS	_	29	nmod	_	_
39	with	with	IN	IN	_	41	case	_	_
40	bipolar	bipolar	JJ	JJ	_	41	amod	_	_
41	disorder	disorder	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	healthy	healthy	JJ	JJ	_	44	amod	_	_
44	subjects	subject	NNS	NNS	_	38	conj	_	_
45	.	.	.	.	_	2	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Platelets	platelet	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	collected	collect	VBN	VBN	_	1	appos	_	_
6	from	from	IN	IN	_	9	case	_	_
7	112	112	CD	CD	_	9	nummod	_	_
8	drug-free	drug-free	JJ	JJ	_	9	amod	_	_
9	patients	patient	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	bipolar	bipolar	JJ	JJ	_	12	amod	_	_
12	disorder	disorder	NN	NN	_	9	nmod	_	_
13	(	(	-LRB-	-LRB-	_	15	punct	_	_
14	52	52	CD	CD	_	15	nummod	_	_
15	euthymic	euthymic	JJ	JJ	_	9	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	29	29	CD	CD	_	18	nummod	_	_
18	depressed	depressed	JJ	JJ	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	31	31	CD	CD	_	22	nummod	_	_
22	manic	manic	JJ	JJ	_	15	conj	_	_
23	)	)	-RRB-	-RRB-	_	15	punct	_	_
24	and	and	CC	CC	_	9	cc	_	_
25	62	62	CD	CD	_	27	nummod	_	_
26	healthy	healthy	JJ	JJ	_	27	amod	_	_
27	subjects	subject	NNS	NNS	_	9	conj	_	_
28	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	levels	level	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cAMP-dependent	camp-dependent	JJ	JJ	_	6	amod	_	_
5	protein	protein	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Rap1	rap1	NN	NN	_	6	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	assessed	assess	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	14	case	_	_
12	Western	western	NN	NN	_	14	compound	_	_
13	blot	blot	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	immunostaining	immunostaining	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	computer-assisted	computer-assisted	JJ	JJ	_	20	amod	_	_
20	imaging	imaging	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	immunolabeling	immunolabeling	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	catalytic	catalytic	JJ	JJ	_	8	amod	_	_
8	subunit	subunit	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	cAMP-dependent	camp-dependent	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	kinase	kinase	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	15	cop	_	_
14	significantly	significantly	RB	RB	_	15	advmod	_	_
15	different	different	JJ	JJ	_	1	appos	_	_
16	among	among	IN	IN	_	17	case	_	_
17	groups	group	NNS	NNS	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	P	p	NN	NN	_	20	dep	_	_
20	&lt;	&lt;	JJR	JJR	_	15	parataxis	_	_
21	.001	.001	CD	CD	_	20	nummod	_	_
22	)	)	-RRB-	-RRB-	_	20	punct	_	_
23	,	,	,	,	_	15	punct	_	_
24	with	with	IN	IN	_	26	case	_	_
25	higher	higher	JJR	JJR	_	26	amod	_	_
26	values	value	NNS	NNS	_	15	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	untreated	untreated	JJ	JJ	_	32	amod	_	_
29	depressed	depressed	JJ	JJ	_	32	amod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	manic	manic	JJ	JJ	_	29	conj	_	_
32	patients	patient	NNS	NNS	_	26	nmod	_	_
33	with	with	IN	IN	_	35	case	_	_
34	bipolar	bipolar	JJ	JJ	_	35	amod	_	_
35	disorder	disorder	NN	NN	_	32	nmod	_	_
36	compared	compare	VBN	VBN	_	40	case	_	_
37	with	with	IN	IN	_	40	case	_	_
38	untreated	untreated	JJ	JJ	_	40	amod	_	_
39	euthymic	euthymic	JJ	JJ	_	40	amod	_	_
40	patients	patient	NNS	NNS	_	26	nmod	_	_
41	with	with	IN	IN	_	43	case	_	_
42	bipolar	bipolar	JJ	JJ	_	43	amod	_	_
43	disorder	disorder	NN	NN	_	40	nmod	_	_
44	and	and	CC	CC	_	40	cc	_	_
45	healthy	healthy	JJ	JJ	_	46	amod	_	_
46	subjects	subject	NNS	NNS	_	40	conj	_	_
47	.	.	.	.	_	1	punct	_	_

1	No	no	DT	DT	_	3	neg	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	differences	difference	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	immunolabeling	immunolabeling	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	subunits	subunit	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	type	type	NN	NN	_	12	dep	_	_
15	I	i	CD	CD	_	14	nummod	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	type	type	NN	NN	_	14	conj	_	_
18	II	ii	CD	CD	_	17	nummod	_	_
19	)	)	-RRB-	-RRB-	_	14	punct	_	_
20	of	of	IN	IN	_	23	case	_	_
21	cAMP-dependent	camp-dependent	JJ	JJ	_	23	amod	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	kinase	kinase	NN	NN	_	12	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	immunolabeling	immunolabeling	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Rap1	rap1	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	significantly	significantly	RB	RB	_	7	advmod	_	_
7	higher	higher	JJR	JJR	_	0	root	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	P	p	NN	NN	_	10	dep	_	_
10	&lt;	&lt;	JJR	JJR	_	7	dep	_	_
11	.001	.001	CD	CD	_	10	nummod	_	_
12	)	)	-RRB-	-RRB-	_	10	punct	_	_
13	in	in	IN	IN	_	21	case	_	_
14	untreated	untreated	JJ	JJ	_	21	amod	_	_
15	euthymic	euthymic	JJ	JJ	_	21	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	depressed	depressed	JJ	JJ	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	manic	manic	JJ	JJ	_	15	conj	_	_
21	patients	patient	NNS	NNS	_	7	nmod	_	_
22	than	than	IN	IN	_	25	case	_	_
23	in	in	IN	IN	_	25	case	_	_
24	healthy	healthy	JJ	JJ	_	25	amod	_	_
25	persons	person	NNS	NNS	_	7	advcl	_	_
26	.	.	.	.	_	7	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Levels	level	NNS	NNS	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Rap1	rap1	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	the	the	DT	DT	_	9	det	_	_
8	catalytic	catalytic	JJ	JJ	_	9	amod	_	_
9	subunit	subunit	NN	NN	_	5	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	cAMP-dependent	camp-dependent	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	9	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	altered	alter	VBN	VBN	_	1	appos	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	platelets	platelet	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	bipolar	bipolar	JJ	JJ	_	21	amod	_	_
21	patients	patient	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	provide	provide	VB	VB	_	0	root	_	_
5	clues	clue	NNS	NNS	_	4	dobj	_	_
6	toward	toward	IN	IN	_	7	mark	_	_
7	understanding	understand	VBG	VBG	_	5	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	involvement	involvement	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cAMP	camp	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	pathogenesis	pathogenesis	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	bipolar	bipolar	JJ	JJ	_	18	amod	_	_
18	disorder	disorder	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	functional	functional	JJ	JJ	_	5	amod	_	_
5	significance	significance	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	p38alpha	p38alpha	NN	NN	_	10	compound	_	_
8	mitogen-activated	mitogen-activated	JJ	JJ	_	10	amod	_	_
9	protein	protein	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	2	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	13	amod	_	_
13	neutrophils	neutrophil	NNS	NNS	_	2	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	leukocytes	leukocyte	NNS	NNS	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	proinflammatory	proinflammatory	JJ	JJ	_	6	amod	_	_
6	stimuli	stimulus	NNS	NNS	_	1	nmod	_	_
7	selectively	selectively	RB	RB	_	8	advmod	_	_
8	initiates	initiate	VBZ	VBZ	_	0	root	_	_
9	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	8	dobj	_	_
12	via	via	IN	IN	_	14	case	_	_
13	sequential	sequential	JJ	JJ	_	14	amod	_	_
14	phosphorylation	phosphorylation	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	kinases	kinase	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	LPS	lps	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	stimulation	stimulation	NN	NN	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	neutrophils	neutrophil	NNS	NNS	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	known	know	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	result	result	VB	VB	_	10	xcomp	_	_
13	in	in	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	p38	p38	NN	NN	_	19	compound	_	_
17	mitogen-activated	mitogen-activated	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MAPk	mapk	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	;	;	:	:	_	10	punct	_	_
24	however	however	RB	RB	_	10	advmod	_	_
25	,	,	,	,	_	10	punct	_	_
26	the	the	DT	DT	_	30	det	_	_
27	upstream	upstream	JJ	JJ	_	30	amod	_	_
28	activator	activator	NN	NN	_	30	compound	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	s	s	NNS	NNS	_	36	nsubj	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	of	of	IN	IN	_	34	case	_	_
33	p38	p38	NN	NN	_	34	compound	_	_
34	MAPk	mapk	NN	NN	_	30	nmod	_	_
35	is	be	VBZ	VBZ	_	36	cop	_	_
36	unknown	unknown	JJ	JJ	_	10	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	and	and	CC	CC	_	36	cc	_	_
39	consequences	consequence	NNS	NNS	_	44	nsubj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	p38	p38	NN	NN	_	43	compound	_	_
42	MAPk	mapk	NN	NN	_	43	compound	_	_
43	activation	activation	NN	NN	_	39	nmod	_	_
44	remain	remain	VBP	VBP	_	36	conj	_	_
45	largely	largely	RB	RB	_	46	advmod	_	_
46	undefined	undefined	JJ	JJ	_	44	xcomp	_	_
47	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	MAPk	mapk	NN	NN	_	5	compound	_	_
5	kinase	kinase	NN	NN	_	2	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MKK	mkk	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	activates	activate	VBZ	VBZ	_	5	acl:relcl	_	_
11	p38	p38	NN	NN	_	12	compound	_	_
12	MAPk	mapk	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	response	response	NN	NN	_	16	dep	_	_
15	to	to	TO	TO	_	16	case	_	_
16	LPS	lps	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	the	the	DT	DT	_	21	det	_	_
19	p38	p38	NN	NN	_	21	compound	_	_
20	MAPk	mapk	NN	NN	_	21	compound	_	_
21	isoforms	isoform	NNS	NNS	_	5	conj	_	_
22	that	that	WDT	WDT	_	24	nsubjpass	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	activated	activate	VBN	VBN	_	21	acl:relcl	_	_
25	as	as	IN	IN	_	26	case	_	_
26	part	part	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	pathway	pathway	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	5	punct	_	_
31	and	and	CC	CC	_	5	cc	_	_
32	the	the	DT	DT	_	34	det	_	_
33	functional	functional	JJ	JJ	_	34	amod	_	_
34	responses	response	NNS	NNS	_	5	conj	_	_
35	affected	affect	VBN	VBN	_	34	acl	_	_
36	by	by	IN	IN	_	39	case	_	_
37	p38	p38	NN	NN	_	39	compound	_	_
38	MAPk	mapk	NN	NN	_	39	compound	_	_
39	activation	activation	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	MKK3	mkk3	NN	NN	_	9	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	MKK4	mkk4	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	MKK6	mkk6	NN	NN	_	2	conj	_	_
8	all	all	DT	DT	_	2	advmod	_	_
9	activated	activate	VBD	VBD	_	19	advcl	_	_
10	p38	p38	NN	NN	_	11	compound	_	_
11	MAPk	mapk	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	experimental	experimental	JJ	JJ	_	14	amod	_	_
14	models	model	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	19	punct	_	_
16	only	only	RB	RB	_	17	advmod	_	_
17	MKK3	mkk3	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	activate	activate	VB	VB	_	19	xcomp	_	_
22	recombinant	recombinant	JJ	JJ	_	24	amod	_	_
23	p38	p38	NN	NN	_	24	compound	_	_
24	MAPk	mapk	NN	NN	_	21	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	LPS-treated	lps-treated	JJ	JJ	_	27	amod	_	_
27	neutrophils	neutrophil	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	19	punct	_	_

1	Of	of	IN	IN	_	4	case	_	_
2	p38	p38	NN	NN	_	4	compound	_	_
3	MAPk	mapk	NN	NN	_	4	compound	_	_
4	isoforms	isoform	NNS	NNS	_	12	nmod	_	_
5	studied	study	VBN	VBN	_	4	acl	_	_
6	,	,	,	,	_	12	punct	_	_
7	only	only	RB	RB	_	8	advmod	_	_
8	p38alpha	p38alpha	NN	NN	_	12	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	p38delta	p38delta	NN	NN	_	8	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	12	punct	_	_

1	LPS	lps	NN	NN	_	2	compound	_	_
2	stimulation	stimulation	NN	NN	_	4	nsubj	_	_
3	selectively	selectively	RB	RB	_	4	advmod	_	_
4	activated	activate	VBD	VBD	_	0	root	_	_
5	p38alpha	p38alpha	NN	NN	_	4	dobj	_	_
6	.	.	.	.	_	4	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	inhibitors	inhibitor	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	p38alpha	p38alpha	NN	NN	_	5	compound	_	_
5	MAPk	mapk	NN	NN	_	2	nmod	_	_
6	blocked	block	VBD	VBD	_	0	root	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	8	amod	_	_
8	adhesion	adhesion	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	factor-kappa	factor-kappa	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	16	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	activation	activation	NN	NN	_	8	conj	_	_
17	,	,	,	,	_	8	punct	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	synthesis	synthesis	NN	NN	_	8	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	necrosis	necrosis	NN	NN	_	23	compound	_	_
23	factor-alpha	factor-alpha	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	p38alpha	p38alpha	NN	NN	_	4	compound	_	_
4	MAPk	mapk	NN	NN	_	1	nmod	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	transient	transient	JJ	JJ	_	9	amod	_	_
9	decrease	decrease	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	accumulation	accumulation	NN	NN	_	9	nmod	_	_
14	but	but	CC	CC	_	9	cc	_	_
15	persistent	persistent	JJ	JJ	_	16	amod	_	_
16	loss	loss	NN	NN	_	9	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	19	compound	_	_
19	synthesis	synthesis	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	pathway	pathway	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	12	nmod	_	_
8	LPS	lps	NN	NN	_	9	compound	_	_
9	stimulation	stimulation	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	neutrophils	neutrophil	NNS	NNS	_	9	nmod	_	_
12	results	result	VBZ	VBZ	_	5	acl:relcl	_	_
13	in	in	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	MKK3	mkk3	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	21	nsubj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	turn	turn	NN	NN	_	21	nmod	_	_
21	activates	activate	VBZ	VBZ	_	16	acl:relcl	_	_
22	p38alpha	p38alpha	NN	NN	_	23	compound	_	_
23	MAPk	mapk	NN	NN	_	21	dobj	_	_
24	,	,	,	,	_	21	punct	_	_
25	ultimately	ultimately	RB	RB	_	26	advmod	_	_
26	regulating	regulate	VBG	VBG	_	21	advcl	_	_
27	adhesion	adhesion	NN	NN	_	26	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	NF-kappaB	nf-kappab	NN	NN	_	30	compound	_	_
30	activation	activation	NN	NN	_	27	conj	_	_
31	,	,	,	,	_	27	punct	_	_
32	enhanced	enhance	VBN	VBN	_	34	amod	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	27	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	TNF-alpha	tnf-alpha	NN	NN	_	34	nmod	_	_
37	,	,	,	,	_	27	punct	_	_
38	and	and	CC	CC	_	27	cc	_	_
39	regulation	regulation	NN	NN	_	27	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	TNF-alpha	tnf-alpha	NN	NN	_	42	compound	_	_
42	synthesis	synthesis	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IL-4-inducible	il-4-inducible	JJ	JJ	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	type	type	NN	NN	_	1	nmod	_	_
11	I	i	CD	CD	_	10	nummod	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	II	ii	CD	CD	_	15	nummod	_	_
15	interferons	interferon	NNS	NNS	_	10	conj	_	_
16	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Th2-type	th2-type	JJ	JJ	_	3	amod	_	_
3	cytokines	cytokine	NNS	NNS	_	15	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	interleukin-4	interleukin-4	NN	NN	_	3	appos	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-4	il-4	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	interleukin-13	interleukin-13	NN	NN	_	5	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL-13	il-13	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	3	punct	_	_
15	induce	induce	VBP	VBP	_	0	root	_	_
16	expression	expression	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	distinct	distinct	JJ	JJ	_	20	amod	_	_
20	subset	subset	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	genes	gene	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	human	human	JJ	JJ	_	25	amod	_	_
25	monocytes	monocyte	NNS	NNS	_	20	nmod	_	_
26	,	,	,	,	_	20	punct	_	_
27	including	include	VBG	VBG	_	28	case	_	_
28	FcepsilonRIIb	fcepsilonriib	NN	NN	_	20	nmod	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	CD23	cd23	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	28	punct	_	_
33	15-lipoxygenase	15-lipoxygenase	NN	NN	_	28	conj	_	_
34	,	,	,	,	_	28	punct	_	_
35	IL-1	il-1	NN	NN	_	37	compound	_	_
36	receptor	receptor	NN	NN	_	37	compound	_	_
37	antagonist	antagonist	NN	NN	_	28	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	IL-1ra	il-1ra	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	,	,	,	,	_	28	punct	_	_
42	and	and	CC	CC	_	28	cc	_	_
43	type	type	NN	NN	_	44	compound	_	_
44	I	i	CD	CD	_	28	conj	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	type	type	NN	NN	_	44	conj	_	_
47	II	ii	CD	CD	_	49	nummod	_	_
48	IL-1	il-1	NN	NN	_	49	compound	_	_
49	receptors	receptor	NNS	NNS	_	44	dep	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	IL-1R	il-1r	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	.	.	.	.	_	15	punct	_	_

1	Type	type	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	3	nummod	_	_
3	interferons	interferon	NNS	NNS	_	16	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IFN-alpha	ifn-alpha	NN	NN	_	3	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IFN-beta	ifn-beta	NN	NN	_	5	conj	_	_
8	)	)	-RRB-	-RRB-	_	5	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	type	type	NN	NN	_	12	compound	_	_
11	II	ii	CD	CD	_	12	nummod	_	_
12	interferon	interferon	NN	NN	_	3	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	inhibit	inhibit	VBP	VBP	_	0	root	_	_
17	induction	induction	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	genes	gene	NNS	NNS	_	17	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	IL-4	il-4	NN	NN	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-13	il-13	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	14	nsubjpass	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	IFNs	ifn	NNS	NNS	_	8	nsubj	_	_
8	mediate	mediate	VBP	VBP	_	4	acl:relcl	_	_
9	this	this	DT	DT	_	10	det	_	_
10	inhibition	inhibition	NN	NN	_	8	dobj	_	_
11	has	have	VBZ	VBZ	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	defined	define	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	overview	overview	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	discuss	discuss	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	STAT6	stat6	NN	NN	_	12	appos	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	signal	signal	NN	NN	_	17	compound	_	_
17	transducer	transducer	NN	NN	_	14	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	activator	activator	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	transcription-6	transcription-6	NN	NN	_	17	nmod	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	in	in	IN	IN	_	24	mark	_	_
24	mediating	mediate	VBG	VBG	_	8	acl	_	_
25	IL-4-	il-4-	NN	NN	_	29	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IL-13-induced	il-13-induced	JJ	JJ	_	25	conj	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	24	dobj	_	_
30	in	in	IN	IN	_	31	case	_	_
31	monocytes	monocyte	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	discuss	discuss	VB	VB	_	0	root	_	_
4	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
5	recent	recent	JJ	JJ	_	6	amod	_	_
6	findings	finding	NNS	NNS	_	3	dobj	_	_
7	that	that	IN	IN	_	14	mark	_	_
8	type	type	NN	NN	_	14	nsubj	_	_
9	I	i	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	type	type	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	IFNs	ifn	NNS	NNS	_	8	conj	_	_
14	suppress	suppress	VBP	VBP	_	6	ccomp	_	_
15	IL-4/IL-13-inducible	il-4/il-13-inducible	JJ	JJ	_	17	amod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	inhibiting	inhibit	VBG	VBG	_	14	advcl	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	19	dobj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	translocation	translocation	NN	NN	_	21	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	STAT6	stat6	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	type	type	NN	NN	_	2	nmod	_	_
5	I	i	CD	CD	_	4	nummod	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	type	type	NN	NN	_	9	compound	_	_
8	II	ii	CD	CD	_	9	nummod	_	_
9	IFNs	ifn	NNS	NNS	_	4	conj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	inhibit	inhibit	VB	VB	_	2	acl	_	_
12	IL-4/IL-13-induced	il-4/il-13-induced	JJ	JJ	_	14	amod	_	_
13	STAT6	stat6	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	dobj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	dose-	dose-	NN	NN	_	0	root	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	time-dependent	time-dependent	JJ	JJ	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	unique	unique	JJ	JJ	_	16	conj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
26	because	because	IN	IN	_	28	mark	_	_
27	IFNs	ifn	NNS	NNS	_	28	nsubj	_	_
28	induce	induce	VBP	VBP	_	16	advcl	_	_
29	the	the	DT	DT	_	31	det	_	_
30	same	same	JJ	JJ	_	31	amod	_	_
31	effects	effect	NNS	NNS	_	28	dobj	_	_
32	in	in	IN	IN	_	33	case	_	_
33	fibroblasts	fibroblast	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	16	punct	_	_

1	Inhibition	inhibition	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	STAT6	stat6	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	is	be	VBZ	VBZ	_	7	cop	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	evident	evident	JJ	JJ	_	0	root	_	_
8	unless	unless	IN	IN	_	11	mark	_	_
9	cells	cell	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	preincubated	preincubate	VBN	VBN	_	7	advcl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	IFN	ifn	NN	NN	_	11	nmod	_	_
14	for	for	IN	IN	_	18	case	_	_
15	at	at	IN	IN	_	16	case	_	_
16	least	least	JJS	JJS	_	17	nmod:npmod	_	_
17	1	1	CD	CD	_	18	nummod	_	_
18	h	h	NN	NN	_	11	nmod	_	_
19	before	before	IN	IN	_	21	case	_	_
20	IL-4	il-4	NN	NN	_	21	compound	_	_
21	stimulation	stimulation	NN	NN	_	11	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	inhibition	inhibition	NN	NN	_	6	nsubjpass	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	actinomycin	actinomycin	NN	NN	_	9	compound	_	_
9	D	d	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	indicating	indicate	VBG	VBG	_	6	xcomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	requirement	requirement	NN	NN	_	11	dobj	_	_
14	for	for	IN	IN	_	17	case	_	_
15	de	de	FW	FW	_	17	amod	_	_
16	novo	novo	FW	FW	_	15	dep	_	_
17	transcription	transcription	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	12	nmod	_	_
7	stimulation	stimulation	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IFN	ifn	NN	NN	_	7	nmod	_	_
12	activates	activate	VBZ	VBZ	_	4	acl:relcl	_	_
13	de	de	FW	FW	_	15	amod	_	_
14	novo	novo	FW	FW	_	13	dep	_	_
15	synthesis	synthesis	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	possibly	possibly	RB	RB	_	25	advmod	_	_
22	one	one	CD	CD	_	25	nummod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	more	more	JJR	JJR	_	22	conj	_	_
25	members	member	NNS	NNS	_	19	appos	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	SOCS/SSI/CIS	socs/ssi/cis	NN	NN	_	30	compound	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	family	family	NN	NN	_	25	nmod	_	_
31	,	,	,	,	_	19	punct	_	_
32	capable	capable	JJ	JJ	_	19	amod	_	_
33	of	of	IN	IN	_	34	mark	_	_
34	suppressing	suppress	VBG	VBG	_	32	advcl	_	_
35	activation	activation	NN	NN	_	34	dobj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	STAT6	stat6	NN	NN	_	35	nmod	_	_
38	by	by	IN	IN	_	39	case	_	_
39	IL-4	il-4	NN	NN	_	35	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	IL-13	il-13	NN	NN	_	39	conj	_	_
42	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	4	mark	_	_
2	STAT6	stat6	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	plays	play	VBZ	VBZ	_	23	advcl	_	_
5	an	a	DT	DT	_	7	det	_	_
6	essential	essential	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	IL-4/IL-13-induced	il-4/il-13-induced	JJ	JJ	_	11	amod	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	4	nmod	_	_
12	,	,	,	,	_	23	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	23	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IFN-beta	ifn-beta	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IFN-gamma	ifn-gamma	NN	NN	_	16	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	inhibit	inhibit	VB	VB	_	14	acl	_	_
21	STAT6	stat6	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	provides	provide	VBZ	VBZ	_	0	root	_	_
24	an	a	DT	DT	_	25	det	_	_
25	explanation	explanation	NN	NN	_	23	dobj	_	_
26	for	for	IN	IN	_	30	mark	_	_
27	how	how	WRB	WRB	_	30	advmod	_	_
28	IFNs	ifn	NNS	NNS	_	30	nsubj	_	_
29	can	can	MD	MD	_	30	aux	_	_
30	suppress	suppress	VB	VB	_	25	acl	_	_
31	IL-4/IL-13-inducible	il-4/il-13-inducible	JJ	JJ	_	33	amod	_	_
32	gene	gene	NN	NN	_	33	compound	_	_
33	expression	expression	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	23	punct	_	_

1	Lineage-specific	lineage-specific	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT3	stat3	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	interferon-gamma	interferon-gamma	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	neutrophils	neutrophil	NNS	NNS	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	Binding	binding	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	interferon-gamma	interferon-gamma	NN	NN	_	1	nmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IFN-gamma	ifn-gamma	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	to	to	TO	TO	_	10	case	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	heterodimeric	heterodimeric	JJ	JJ	_	10	amod	_	_
10	receptor	receptor	NN	NN	_	1	nmod	_	_
11	induces	induce	VBZ	VBZ	_	0	root	_	_
12	activation	activation	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	kinases	kinase	NNS	NNS	_	12	nmod	_	_
17	JAK1	jak1	NN	NN	_	16	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	JAK2	jak2	NN	NN	_	17	conj	_	_
20	followed	follow	VBN	VBN	_	12	acl	_	_
21	by	by	IN	IN	_	23	case	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	STAT1alpha	stat1alpha	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT1alpha	stat1alpha	NN	NN	_	2	nmod	_	_
5	at	at	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	achieved	achieve	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	interaction	interaction	NN	NN	_	10	nmod	_	_
14	between	between	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	cytosolic	cytosolic	JJ	JJ	_	18	amod	_	_
17	tyrosine	tyrosine	NN	NN	_	18	compound	_	_
18	motif	motif	NN	NN	_	13	nmod	_	_
19	including	include	VBG	VBG	_	20	case	_	_
20	Y440	y440	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	IFN-gamma	ifn-gamma	NN	NN	_	25	compound	_	_
24	receptor	receptor	NN	NN	_	25	compound	_	_
25	alpha-chain	alpha-chain	NN	NN	_	18	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	the	the	DT	DT	_	29	det	_	_
28	SH2	sh2	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	25	conj	_	_
30	of	of	IN	IN	_	31	case	_	_
31	STAT1alpha	stat1alpha	NN	NN	_	25	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	,	,	,	,	_	13	punct	_	_
5	in	in	IN	IN	_	6	case	_	_
6	addition	addition	NN	NN	_	13	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	STAT1alpha	stat1alpha	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	STAT3	stat3	NN	NN	_	13	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	activated	activate	VBN	VBN	_	2	ccomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	neutrophils	neutrophil	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT3	stat3	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	eosinophils	eosinophil	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	monocytes	monocyte	NNS	NNS	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	HL-60	hl-60	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	10	conj	_	_
17	,	,	,	,	_	7	punct	_	_
18	although	although	IN	IN	_	23	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	STAT3	stat3	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	expressed	express	VBN	VBN	_	7	advcl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	type-specific	type-specific	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STAT3	stat3	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	observed	observe	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	neutrophils	neutrophil	NNS	NNS	_	11	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	differentiated	differentiate	VBN	VBN	_	13	acl:relcl	_	_
17	in	in	FW	FW	_	18	compound	_	_
18	vitro	vitro	FW	FW	_	16	advmod	_	_
19	from	from	IN	IN	_	24	case	_	_
20	human	human	JJ	JJ	_	24	amod	_	_
21	CD34+	cd34+	JJ	JJ	_	24	amod	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	24	amod	_	_
23	stem	stem	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	16	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	single	single	JJ	JJ	_	8	amod	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	10	nsubj	_	_
9	can	can	MD	MD	_	10	aux	_	_
10	activate	activate	VB	VB	_	3	ccomp	_	_
11	different	different	JJ	JJ	_	14	amod	_	_
12	STAT	stat	NN	NN	_	14	compound	_	_
13	family	family	NN	NN	_	14	compound	_	_
14	members	member	NNS	NNS	_	10	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	cell-specific	cell-specific	JJ	JJ	_	18	amod	_	_
18	manner	manner	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	which	which	WDT	WDT	_	22	nsubj	_	_
21	might	might	MD	MD	_	22	aux	_	_
22	result	result	VB	VB	_	10	ccomp	_	_
23	in	in	IN	IN	_	26	case	_	_
24	cell-specific	cell-specific	JJ	JJ	_	26	amod	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	transcription	transcription	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
4	p50/p65	p50/p65	NN	NN	_	5	compound	_	_
5	heterodimer	heterodimer	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	activation	activation	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	pro-interleukin-1beta	pro-interleukin-1beta	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	at	at	IN	IN	_	15	case	_	_
14	two	two	CD	CD	_	15	nummod	_	_
15	subregions	subregion	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	upstream	upstream	JJ	JJ	_	20	amod	_	_
19	enhancer	enhancer	NN	NN	_	20	compound	_	_
20	element	element	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	region	region	NN	NN	_	23	nsubjpass	_	_
3	between	between	IN	IN	_	7	case	_	_
4	-3134	-3134	CD	CD	_	7	nummod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	-2729	-2729	CD	CD	_	4	conj	_	_
7	bp	bp	NN	NN	_	2	nmod	_	_
8	upstream	upstream	RB	RB	_	2	advmod	_	_
9	from	from	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	21	case	_	_
14	the	the	DT	DT	_	21	det	_	_
15	human	human	JJ	JJ	_	21	amod	_	_
16	pro-interleukin	pro-interleukin	NN	NN	_	21	compound	_	_
17	1beta	1beta	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	proIL-1beta	proil-1beta	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	gene	gene	NN	NN	_	12	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	identified	identify	VBN	VBN	_	0	root	_	_
24	as	as	IN	IN	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	LPS-responsive	lps-responsive	JJ	JJ	_	28	amod	_	_
27	enhancer	enhancer	NN	NN	_	28	compound	_	_
28	element	element	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	29	nmod	_	_
4	,	,	,	,	_	29	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	influence	influence	NN	NN	_	29	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	sequences	sequence	NNS	NNS	_	6	nmod	_	_
10	located	located	JJ	JJ	_	9	amod	_	_
11	between	between	IN	IN	_	12	case	_	_
12	-3134	-3134	CD	CD	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	-2987	-2987	CD	CD	_	12	conj	_	_
15	on	on	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activity	activity	NN	NN	_	6	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	proIL-1beta	proil-1beta	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	LPS-stimulated	lps-stimulated	JJ	JJ	_	27	amod	_	_
25	Raw	raw	NN	NN	_	27	compound	_	_
26	264.7	264.7	CD	CD	_	27	nummod	_	_
27	cells	cell	NNS	NNS	_	6	nmod	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	examined	examine	VBN	VBN	_	0	root	_	_
30	in	in	IN	IN	_	31	case	_	_
31	detail	detail	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	29	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	15	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	6	case	_	_
5	transient	transient	JJ	JJ	_	6	amod	_	_
6	transfection	transfection	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	fos-CAT	fos-cat	JJ	JJ	_	9	amod	_	_
9	constructs	construct	NNS	NNS	_	6	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	contained	contain	VBD	VBD	_	9	acl:relcl	_	_
12	serial	serial	JJ	JJ	_	14	amod	_	_
13	5'-deletion	5'-deletion	JJ	JJ	_	14	amod	_	_
14	mutations	mutation	NNS	NNS	_	11	dobj	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	region	region	NN	NN	_	23	nsubj	_	_
19	between	between	IN	IN	_	20	case	_	_
20	-3134	-3134	CD	CD	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	-3059	-3059	CD	CD	_	20	conj	_	_
23	appears	appear	VBZ	VBZ	_	15	ccomp	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	required	require	VBN	VBN	_	23	xcomp	_	_
27	for	for	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	induction	induction	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	transcription	transcription	NN	NN	_	29	nmod	_	_
32	by	by	IN	IN	_	33	case	_	_
33	LPS	lps	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	15	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	shift	shift	NN	NN	_	4	compound	_	_
3	assay	assay	NN	NN	_	4	compound	_	_
4	studies	study	NNS	NNS	_	22	nsubj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	synthetic	synthetic	JJ	JJ	_	7	amod	_	_
7	oligonucleotides	oligonucleotide	NNS	NNS	_	4	nmod	_	_
8	corresponding	correspond	VBG	VBG	_	7	acl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	partial	partial	JJ	JJ	_	11	amod	_	_
11	sequences	sequence	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	latter	latter	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	11	conj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	stimulated	stimulate	VBN	VBN	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	revealed	reveal	VBD	VBD	_	0	root	_	_
23	specific	specific	JJ	JJ	_	26	amod	_	_
24	protein	protein	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	sites	site	NNS	NNS	_	22	dobj	_	_
27	between	between	IN	IN	_	28	case	_	_
28	-3110	-3110	CD	CD	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	-3090	-3090	CD	CD	_	28	conj	_	_
31	and	and	CC	CC	_	28	cc	_	_
32	between	between	IN	IN	_	33	case	_	_
33	-3079	-3079	CD	CD	_	28	conj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	-3059	-3059	CD	CD	_	33	conj	_	_
36	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	bindings	binding	NNS	NNS	_	9	nsubj	_	_
4	were	be	VBD	VBD	_	9	cop	_	_
5	time	time	NN	NN	_	9	nmod:npmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	LPS	lps	NN	NN	_	8	compound	_	_
8	dose	dose	NN	NN	_	5	conj	_	_
9	dependent	dependent	JJ	JJ	_	0	root	_	_
10	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	supershift	supershift	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	2	nmod	_	_
6	using	use	VBG	VBG	_	5	acl	_	_
7	specific	specific	JJ	JJ	_	8	amod	_	_
8	antibodies	antibody	NNS	NNS	_	6	dobj	_	_
9	against	against	IN	IN	_	11	case	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	8	nmod	_	_
12	suggested	suggest	VBD	VBD	_	0	root	_	_
13	that	that	IN	IN	_	17	mark	_	_
14	both	both	DT	DT	_	16	det	_	_
15	binding	bind	VBG	VBG	_	16	amod	_	_
16	complexes	complex	NNS	NNS	_	17	nsubj	_	_
17	contained	contain	VBD	VBD	_	12	ccomp	_	_
18	the	the	DT	DT	_	20	det	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	components	component	NNS	NNS	_	17	dobj	_	_
21	p50	p50	NN	NN	_	20	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	p65	p65	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	did	do	VBD	VBD	_	28	aux	_	_
27	not	not	RB	RB	_	28	neg	_	_
28	contain	contain	VB	VB	_	17	conj	_	_
29	other	other	JJ	JJ	_	31	amod	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	proteins	protein	NNS	NNS	_	28	dobj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	p52	p52	NN	NN	_	31	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	c-Rel	c-rel	NN	NN	_	33	appos	_	_
36	,	,	,	,	_	33	punct	_	_
37	Rel	rel	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	33	appos	_	_
39	)	)	-RRB-	-RRB-	_	33	punct	_	_
40	,	,	,	,	_	31	punct	_	_
41	AP-1	ap-1	NN	NN	_	42	compound	_	_
42	proteins	protein	NNS	NNS	_	31	appos	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	c-Fos	c-fos	NN	NN	_	42	dep	_	_
45	,	,	,	,	_	44	punct	_	_
46	C-Jun	c-jun	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	44	punct	_	_
48	,	,	,	,	_	31	punct	_	_
49	CREB	creb	NN	NN	_	31	appos	_	_
50	or	or	CC	CC	_	49	cc	_	_
51	C/EBPbeta	c/ebpbeta	NN	NN	_	49	conj	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	NF-IL6	nf-il6	NN	NN	_	49	appos	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	.	.	.	.	_	12	punct	_	_

1	Mutation	mutation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	either	either	DT	DT	_	1	nmod	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	putative	putative	JJ	JJ	_	8	amod	_	_
7	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	8	amod	_	_
8	sites	site	NNS	NNS	_	3	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	enhancer	enhancer	NN	NN	_	12	compound	_	_
12	element	element	NN	NN	_	8	nmod	_	_
13	decreased	decrease	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	17	det	_	_
15	LPS-stimulated	lps-stimulated	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	7	amod	_	_
7	sites	site	NNS	NNS	_	18	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	11	nsubj	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	located	located	JJ	JJ	_	7	acl:relcl	_	_
12	between	between	IN	IN	_	13	case	_	_
13	-3134	-3134	CD	CD	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	-3059	-3059	CD	CD	_	13	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	critical	critical	JJ	JJ	_	3	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	proIL-1beta	proil-1beta	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Analysis	analysis	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	modulation	modulation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	myelopoiesis	myelopoiesis	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	leukemogenesis	leukemogenesis	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	1	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	myeloid	myeloid	JJ	JJ	_	3	amod	_	_
3	leukemia	leukemia	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	AML	aml	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	still	still	RB	RB	_	9	advmod	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	mortality	mortality	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	60	60	CD	CD	_	16	compound	_	_
15	to	to	TO	TO	_	16	dep	_	_
16	80	80	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	AML	aml	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	characterized	characterize	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	block	block	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	myeloid	myeloid	JJ	JJ	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	8	nsubj	_	_
4	PU.1	pu.1	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	C/EBPalpha	c/ebpalpha	NN	NN	_	4	conj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	responsible	responsible	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	12	case	_	_
10	normal	normal	JJ	JJ	_	12	amod	_	_
11	myeloid	myeloid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	8	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	stem	stem	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	granulocytes	granulocyte	NNS	NNS	_	17	conj	_	_
20	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	PU.1	pu.1	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	expression	expression	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	15	case	_	_
8	the	the	DT	DT	_	15	det	_	_
9	macrophage	macrophage	NN	NN	_	15	compound	_	_
10	colony-stimulating	colony-stimulating	JJ	JJ	_	15	amod	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	M-CSF	m-csf	NN	NN	_	15	compound	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	receptor	receptor	NN	NN	_	6	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	development	development	NN	NN	_	6	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	whereas	whereas	IN	IN	_	5	dep	_	_
23	C/EBPalpha	c/ebpalpha	NN	NN	_	24	nsubj	_	_
24	increases	increase	VBZ	VBZ	_	5	parataxis	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	35	case	_	_
28	the	the	DT	DT	_	35	det	_	_
29	granulocyte	granulocyte	NN	NN	_	35	compound	_	_
30	colony-stimulating	colony-stimulating	JJ	JJ	_	35	amod	_	_
31	factor	factor	NN	NN	_	35	compound	_	_
32	(	(	-LRB-	-LRB-	_	35	punct	_	_
33	G-CSF	g-csf	NN	NN	_	35	compound	_	_
34	)	)	-RRB-	-RRB-	_	35	punct	_	_
35	receptor	receptor	NN	NN	_	26	nmod	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	leads	lead	VBZ	VBZ	_	24	conj	_	_
38	to	to	TO	TO	_	40	case	_	_
39	mature	mature	JJ	JJ	_	40	amod	_	_
40	granulocytes	granulocyte	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	AML	aml	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	chromosomal	chromosomal	JJ	JJ	_	5	amod	_	_
5	aberrations	aberration	NNS	NNS	_	6	nsubj	_	_
6	result	result	VBP	VBP	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	oncoproteins	oncoprotein	NNS	NNS	_	6	nmod	_	_
9	such	such	JJ	JJ	_	11	case	_	_
10	as	as	IN	IN	_	9	mwe	_	_
11	AML1/ETO	aml1/eto	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	PML/RARalpha	pml/raralpha	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	activated	activate	VBN	VBN	_	17	amod	_	_
17	Ras	ras	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	8	punct	_	_
19	which	which	WDT	WDT	_	21	nsubj	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	deregulate	deregulate	VB	VB	_	8	acl:relcl	_	_
22	genes	gene	NNS	NNS	_	21	dobj	_	_
23	important	important	JJ	JJ	_	22	amod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	normal	normal	JJ	JJ	_	26	amod	_	_
26	myelopoiesis	myelopoiesis	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	AML1/ETO	aml1/eto	NN	NN	_	5	nsubj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	bind	bind	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	C/EBPalpha	c/ebpalpha	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	inhibit	inhibit	VB	VB	_	5	conj	_	_
13	C/EBPalpha-dependent	c/ebpalpha-dependent	JJ	JJ	_	14	amod	_	_
14	transcription	transcription	NN	NN	_	12	dobj	_	_
15	,	,	,	,	_	5	punct	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	block	block	VB	VB	_	5	conj	_	_
18	granulocytic	granulocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	AML1/ETO	aml1/eto	NN	NN	_	6	nsubj	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	synergize	synergize	VB	VB	_	0	root	_	_
7	with	with	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	AML1	aml1	NN	NN	_	6	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	enhance	enhance	VB	VB	_	6	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	M-CSF	m-csf	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	9	det	_	_
7	PML/RARalpha	pml/raralpha	NN	NN	_	9	compound	_	_
8	fusion	fusion	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	10	nsubj	_	_
10	causes	cause	VBZ	VBZ	_	0	root	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	repression	repression	NN	NN	_	10	dobj	_	_
13	by	by	IN	IN	_	14	mark	_	_
14	recruiting	recruit	VBG	VBG	_	10	advcl	_	_
15	the	the	DT	DT	_	23	det	_	_
16	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
17	corepressor	corepressor	NN	NN	_	23	compound	_	_
18	(	(	-LRB-	-LRB-	_	23	punct	_	_
19	N-CoR	n-cor	NN	NN	_	23	compound	_	_
20	)	)	-RRB-	-RRB-	_	23	punct	_	_
21	histone	histone	NN	NN	_	23	compound	_	_
22	deacetylase	deacetylase	NN	NN	_	23	compound	_	_
23	complex	complex	NN	NN	_	14	dobj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	DNA	dna	NN	NN	_	14	nmod	_	_
27	,	,	,	,	_	10	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	results	result	VBZ	VBZ	_	10	ccomp	_	_
30	in	in	IN	IN	_	33	case	_	_
31	decreased	decrease	VBN	VBN	_	33	amod	_	_
32	histone	histone	NN	NN	_	33	compound	_	_
33	acetylation	acetylation	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	a	a	DT	DT	_	38	det	_	_
36	repressive	repressive	JJ	JJ	_	38	amod	_	_
37	chromatin	chromatin	NN	NN	_	38	compound	_	_
38	organization	organization	NN	NN	_	33	conj	_	_
39	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	describe	describe	VBP	VBP	_	0	root	_	_
4	methods	method	NNS	NNS	_	3	dobj	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	investigate	investigate	VB	VB	_	4	acl	_	_
7	whether	whether	IN	IN	_	12	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	how	how	WRB	WRB	_	7	conj	_	_
10	signaling	signaling	JJ	JJ	_	11	amod	_	_
11	agonists	agonist	NNS	NNS	_	12	nsubj	_	_
12	induce	induce	VBP	VBP	_	6	dep	_	_
13	myeloid	myeloid	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	how	how	WRB	WRB	_	19	advmod	_	_
17	oncoproteins	oncoprotein	NNS	NNS	_	19	nsubj	_	_
18	might	might	MD	MD	_	19	aux	_	_
19	cause	cause	VB	VB	_	12	conj	_	_
20	AML	aml	NN	NN	_	19	dobj	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	modulating	modulate	VBG	VBG	_	6	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activity	activity	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	transcription	transcription	NN	NN	_	27	compound	_	_
27	factors	factor	NNS	NNS	_	24	nmod	_	_
28	that	that	WDT	WDT	_	30	nsubj	_	_
29	are	be	VBP	VBP	_	30	cop	_	_
30	pivotal	pivotal	JJ	JJ	_	27	acl:relcl	_	_
31	for	for	IN	IN	_	34	case	_	_
32	normal	normal	JJ	JJ	_	34	amod	_	_
33	myeloid	myeloid	JJ	JJ	_	34	amod	_	_
34	development	development	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Phosphorylation	phosphorylation	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TRAF2	traf2	NN	NN	_	1	nmod	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	binding	binding	NN	NN	_	4	dobj	_	_
6	to	to	TO	TO	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	CD40	cd40	NN	NN	_	10	compound	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	TRAF2	traf2	NN	NN	_	7	nsubj	_	_
2	is	be	VBZ	VBZ	_	7	cop	_	_
3	a	a	DT	DT	_	7	det	_	_
4	signal	signal	NN	NN	_	7	compound	_	_
5	transducing	transducing	NN	NN	_	7	compound	_	_
6	adaptor	adaptor	NN	NN	_	7	compound	_	_
7	molecule	molecule	NN	NN	_	0	root	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	CD40	cd40	NN	NN	_	14	compound	_	_
13	cytoplasmic	cytoplasmic	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	it	it	PRP	PRP	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	aux	_	_
7	phosphorylated	phosphorylated	JJ	JJ	_	3	ccomp	_	_
8	,	,	,	,	_	7	punct	_	_
9	predominantly	predominantly	RB	RB	_	12	advmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	serine	serine	NN	NN	_	12	compound	_	_
12	residues	residue	NNS	NNS	_	7	nmod	_	_
13	,	,	,	,	_	7	punct	_	_
14	when	when	WRB	WRB	_	16	advmod	_	_
15	transiently	transiently	RB	RB	_	16	advmod	_	_
16	overexpressed	overexpress	VBN	VBN	_	7	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	293	293	CD	CD	_	19	nummod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	phosphorylation	phosphorylation	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	cop	_	_
6	related	related	JJ	JJ	_	3	xcomp	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	signaling	signaling	NN	NN	_	10	compound	_	_
10	events	event	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	activated	activate	VBN	VBN	_	10	acl:relcl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	TRAF2	traf2	NN	NN	_	13	nmod	_	_
16	under	under	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	circumstances	circumstance	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	3	punct	_	_
20	since	since	IN	IN	_	25	mark	_	_
21	two	two	CD	CD	_	23	nummod	_	_
22	nonfunctional	nonfunctional	JJ	JJ	_	23	amod	_	_
23	mutants	mutant	NNS	NNS	_	25	nsubjpass	_	_
24	were	be	VBD	VBD	_	25	auxpass	_	_
25	found	find	VBN	VBN	_	3	advcl	_	_
26	to	to	TO	TO	_	28	mark	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	phosphorylated	phosphorylate	VBN	VBN	_	25	xcomp	_	_
29	significantly	significantly	RB	RB	_	30	advmod	_	_
30	less	less	RBR	RBR	_	28	advmod	_	_
31	than	than	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	wild-type	wild-type	JJ	JJ	_	34	amod	_	_
34	protein	protein	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	phosphorylation	phosphorylation	NN	NN	_	5	compound	_	_
5	status	status	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	TRAF2	traf2	NN	NN	_	5	nmod	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	bind	bind	VB	VB	_	13	acl	_	_
19	to	to	TO	TO	_	20	case	_	_
20	CD40	cd40	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	as	as	IN	IN	_	23	mark	_	_
23	evidenced	evidence	VBN	VBN	_	8	advcl	_	_
24	by	by	IN	IN	_	26	case	_	_
25	our	we	PRP$	PRP$	_	26	nmod:poss	_	_
26	observations	observation	NNS	NNS	_	23	nmod	_	_
27	that	that	IN	IN	_	32	mark	_	_
28	the	the	DT	DT	_	29	det	_	_
29	CD40	cd40	NN	NN	_	32	nsubj	_	_
30	cytoplasmic	cytoplasmic	JJ	JJ	_	29	amod	_	_
31	domain	domain	JJ	JJ	_	29	amod	_	_
32	interacted	interact	VBD	VBD	_	26	ccomp	_	_
33	preferentially	preferentially	RB	RB	_	32	advmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	underphosphorylated	underphosphorylate	VBN	VBN	_	36	amod	_	_
36	TRAF2	traf2	NN	NN	_	32	nmod	_	_
37	and	and	CC	CC	_	32	cc	_	_
38	that	that	IN	IN	_	42	mark	_	_
39	phosphatase	phosphatase	NN	NN	_	40	compound	_	_
40	treatment	treatment	NN	NN	_	42	nsubj	_	_
41	significantly	significantly	RB	RB	_	42	advmod	_	_
42	enhanced	enhance	VBD	VBD	_	32	conj	_	_
43	the	the	DT	DT	_	44	det	_	_
44	binding	binding	NN	NN	_	42	dobj	_	_
45	of	of	IN	IN	_	46	case	_	_
46	TRAF2	traf2	NN	NN	_	44	nmod	_	_
47	to	to	TO	TO	_	48	case	_	_
48	CD40	cd40	NN	NN	_	44	nmod	_	_
49	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	from	from	IN	IN	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	studies	study	NNS	NNS	_	2	nmod	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	phosphorylation	phosphorylation	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	TRAF2	traf2	NN	NN	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	likely	likely	JJ	JJ	_	2	ccomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	play	play	VB	VB	_	12	xcomp	_	_
15	an	a	DT	DT	_	17	det	_	_
16	important	important	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	19	mark	_	_
19	regulating	regulate	VBG	VBG	_	14	advcl	_	_
20	signaling	signaling	NN	NN	_	19	dobj	_	_
21	by	by	IN	IN	_	25	case	_	_
22	virtue	virtue	NN	NN	_	25	dep	_	_
23	of	of	IN	IN	_	25	case	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	ability	ability	NN	NN	_	19	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	influence	influence	VB	VB	_	25	acl	_	_
28	the	the	DT	DT	_	30	det	_	_
29	CD40-TRAF2	cd40-traf2	JJ	JJ	_	30	amod	_	_
30	interaction	interaction	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	2	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Cobalt	cobalt	NN	NN	_	2	nmod:npmod	_	_
2	chloride-induced	chloride-induced	JJ	JJ	_	3	amod	_	_
3	signaling	signaling	NN	NN	_	24	nsubjpass	_	_
4	in	in	IN	IN	_	5	case	_	_
5	endothelium	endothelium	NN	NN	_	3	nmod	_	_
6	leading	lead	VBG	VBG	_	5	acl	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	augmented	augmented	JJ	JJ	_	10	amod	_	_
10	adherence	adherence	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	sickle	sickle	JJ	JJ	_	15	amod	_	_
13	red	red	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	transendothelial	transendothelial	JJ	JJ	_	18	amod	_	_
18	migration	migration	NN	NN	_	10	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	monocyte-like	monocyte-like	JJ	JJ	_	22	amod	_	_
21	HL-60	hl-60	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	blocked	block	VBN	VBN	_	0	root	_	_
25	by	by	IN	IN	_	27	case	_	_
26	PAF-receptor	paf-receptor	NN	NN	_	27	compound	_	_
27	antagonist	antagonist	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	24	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	response	response	NN	NN	_	4	dep	_	_
3	to	to	TO	TO	_	4	case	_	_
4	hypoxia	hypoxia	NN	NN	_	16	nmod	_	_
5	,	,	,	,	_	16	punct	_	_
6	sickle	sickle	JJ	JJ	_	9	amod	_	_
7	red	red	JJ	JJ	_	9	amod	_	_
8	blood	blood	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	16	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	SS	ss	NN	NN	_	12	compound	_	_
12	RBC	rbc	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	leukocytes	leukocyte	NNS	NNS	_	9	conj	_	_
16	exhibit	exhibit	VBP	VBP	_	0	root	_	_
17	increased	increase	VBN	VBN	_	18	amod	_	_
18	adherence	adherence	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	vascular	vascular	JJ	JJ	_	22	amod	_	_
22	endothelium	endothelium	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	16	punct	_	_
24	while	while	IN	IN	_	32	mark	_	_
25	diapedesis	diapedesis	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	leukocytes	leukocyte	NNS	NNS	_	25	nmod	_	_
28	through	through	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	blood	blood	NN	NN	_	31	compound	_	_
31	vessel	vessel	NN	NN	_	25	nmod	_	_
32	increases	increase	VBZ	VBZ	_	16	advcl	_	_
33	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	8	det	_	_
4	cellular	cellular	JJ	JJ	_	8	amod	_	_
5	signaling	signaling	NN	NN	_	8	compound	_	_
6	pathway	pathway	NN	NN	_	8	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	15	nsubjpass	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	caused	cause	VBN	VBN	_	8	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	hypoxia	hypoxia	NN	NN	_	10	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	poorly	poorly	RB	RB	_	15	advmod	_	_
15	understood	understand	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	utilized	utilize	VBD	VBD	_	0	root	_	_
3	CoCl2	cocl2	NN	NN	_	2	dobj	_	_
4	as	as	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	mimetic	mimetic	JJ	JJ	_	7	amod	_	_
7	molecule	molecule	NN	NN	_	2	nmod	_	_
8	for	for	IN	IN	_	9	case	_	_
9	hypoxia	hypoxia	NN	NN	_	7	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	study	study	VB	VB	_	2	advcl	_	_
12	cellular	cellular	JJ	JJ	_	14	amod	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	pathways	pathway	NNS	NNS	_	11	dobj	_	_
15	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	19	mark	_	_
4	in	in	IN	IN	_	9	case	_	_
5	human	human	JJ	JJ	_	9	amod	_	_
6	umbilical	umbilical	JJ	JJ	_	9	amod	_	_
7	vein	vein	NN	NN	_	9	compound	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	19	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	HUVEC	huvec	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	19	punct	_	_
14	CoCl2	cocl2	NN	NN	_	19	nsubj	_	_
15	at	at	IN	IN	_	18	case	_	_
16	2	2	CD	CD	_	17	compound	_	_
17	mM	mm	NN	NN	_	18	amod	_	_
18	concentration	concentration	NN	NN	_	14	nmod	_	_
19	induced	induce	VBD	VBD	_	2	ccomp	_	_
20	the	the	DT	DT	_	22	det	_	_
21	surface	surface	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	subset	subset	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	CAMs	cam	NNS	NNS	_	25	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	VCAM-1	vcam-1	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	22	cc	_	_
32	activation	activation	NN	NN	_	22	conj	_	_
33	of	of	IN	IN	_	36	case	_	_
34	transcription	transcription	NN	NN	_	36	compound	_	_
35	factor	factor	NN	NN	_	36	compound	_	_
36	NF-kappaB	nf-kappab	NN	NN	_	32	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	nuclear	nuclear	JJ	JJ	_	40	amod	_	_
40	extracts	extract	NNS	NNS	_	36	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	HUVEC	huvec	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CoCl2	cocl2	NN	NN	_	5	nsubj	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	caused	cause	VBD	VBD	_	0	root	_	_
6	time-dependent	time-dependent	JJ	JJ	_	8	amod	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	17	case	_	_
10	mitogen-activated	mitogen-activated	JJ	JJ	_	17	amod	_	_
11	protein	protein	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	MAP	map	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	kinase	kinase	NN	NN	_	17	compound	_	_
16	isoform	isoform	NN	NN	_	17	compound	_	_
17	ERK2	erk2	NN	NN	_	8	nmod	_	_
18	without	without	IN	IN	_	20	mark	_	_
19	significantly	significantly	RB	RB	_	20	advmod	_	_
20	affecting	affect	VBG	VBG	_	5	advcl	_	_
21	ERK1	erk1	NN	NN	_	20	dobj	_	_
22	,	,	,	,	_	5	punct	_	_
23	indicating	indicate	VBG	VBG	_	5	advcl	_	_
24	ERK2	erk2	NN	NN	_	28	nsubj	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	the	the	DT	DT	_	28	det	_	_
27	preferred	preferred	JJ	JJ	_	28	amod	_	_
28	substrate	substrate	NN	NN	_	23	ccomp	_	_
29	for	for	IN	IN	_	31	case	_	_
30	upstream	upstream	JJ	JJ	_	31	amod	_	_
31	kinase	kinase	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	MAPK	mapk	NN	NN	_	35	compound	_	_
35	pathway	pathway	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Inhibitors	inhibitor	NNS	NNS	_	19	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	MAP	map	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PD98059	pd98059	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	or	or	CC	CC	_	4	cc	_	_
9	platelet-activating	platelet-activating	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	14	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PAF	paf	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-receptor	-receptor	NN	NN	_	15	amod	_	_
15	antagonist	antagonist	NN	NN	_	4	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CV3988	cv3988	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	inhibited	inhibit	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	23	det	_	_
21	CoCl2-induced	cocl2-induced	JJ	JJ	_	23	amod	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
23	activation	activation	NN	NN	_	19	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	VCAM-1	vcam-1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	19	punct	_	_

1	Augmented	augmented	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	VCAM-1	vcam-1	NN	NN	_	2	nmod	_	_
5	led	lead	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	10	case	_	_
7	increased	increase	VBN	VBN	_	10	amod	_	_
8	SS	ss	NN	NN	_	10	compound	_	_
9	RBC	rbc	NN	NN	_	10	compound	_	_
10	adhesion	adhesion	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	inhibitable	inhibitable	JJ	JJ	_	10	amod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	VCAM-1	vcam-1	NN	NN	_	16	compound	_	_
16	antibody	antibody	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Additionally	additionally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	CoCl2	cocl2	NN	NN	_	4	nsubj	_	_
4	caused	cause	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	two-	two-	CD	CD	_	9	nummod	_	_
7	to	to	TO	TO	_	6	dep	_	_
8	threefold	threefold	JJ	JJ	_	6	advmod	_	_
9	increase	increase	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	rate	rate	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	transendothelial	transendothelial	JJ	JJ	_	15	amod	_	_
15	migration	migration	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	monocyte-like	monocyte-like	JJ	JJ	_	19	amod	_	_
18	HL-60	hl-60	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	a	a	DT	DT	_	23	det	_	_
22	twentyfold	twentyfold	JJ	JJ	_	23	amod	_	_
23	increase	increase	NN	NN	_	9	conj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	phosphorylation	phosphorylation	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	31	case	_	_
27	platelet	platelet	NN	NN	_	31	compound	_	_
28	endothelial	endothelial	JJ	JJ	_	31	amod	_	_
29	cell	cell	NN	NN	_	31	compound	_	_
30	adhesion	adhesion	NN	NN	_	31	compound	_	_
31	molecules	molecule	NNS	NNS	_	25	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	PECAM-1	pecam-1	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transendothelial	transendothelial	JJ	JJ	_	3	amod	_	_
3	migration	migration	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	antibody	antibody	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	PECAM-1	pecam-1	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	phosphorylation	phosphorylation	NN	NN	_	15	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PECAM-1	pecam-1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	transendothelial	transendothelial	JJ	JJ	_	7	amod	_	_
7	migration	migration	NN	NN	_	2	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	response	response	NN	NN	_	13	dep	_	_
12	to	to	TO	TO	_	13	case	_	_
13	CoCl2	cocl2	NN	NN	_	2	nmod	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	inhibited	inhibit	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	inhibitor	inhibitor	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	GF109203X	gf109203x	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	augmented	augment	VBN	VBN	_	15	conj	_	_
25	by	by	IN	IN	_	28	case	_	_
26	protein	protein	NN	NN	_	28	compound	_	_
27	phosphatase	phosphatase	NN	NN	_	28	compound	_	_
28	inhibitor	inhibitor	NN	NN	_	24	nmod	_	_
29	(	(	-LRB-	-LRB-	_	31	punct	_	_
30	Calyculin	calyculin	NN	NN	_	31	compound	_	_
31	A	a	NN	NN	_	28	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	15	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	CoCl2-induced	cocl2-induced	JJ	JJ	_	7	amod	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	signals	signal	NNS	NNS	_	15	nsubj	_	_
8	directing	direct	VBG	VBG	_	7	acl	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	VCAM-1	vcam-1	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	HUVEC	huvec	NN	NN	_	10	nmod	_	_
15	involve	involve	VBP	VBP	_	3	ccomp	_	_
16	downstream	downstream	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	MAP	map	NN	NN	_	20	compound	_	_
20	kinase	kinase	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	15	punct	_	_
24	while	while	IN	IN	_	29	mark	_	_
25	the	the	DT	DT	_	26	det	_	_
26	phosphorylation	phosphorylation	NN	NN	_	29	nsubj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	PECAM-1	pecam-1	NN	NN	_	26	nmod	_	_
29	occurs	occur	VBZ	VBZ	_	15	advcl	_	_
30	as	as	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	result	result	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	34	case	_	_
34	activation	activation	NN	NN	_	32	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	PKC	pkc	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	PAF-receptor	paf-receptor	NN	NN	_	5	compound	_	_
5	antagonist	antagonist	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	2	ccomp	_	_
7	the	the	DT	DT	_	11	det	_	_
8	CoCl2-	cocl2-	NN	NN	_	11	amod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	hypoxia-induced	hypoxia-induced	JJ	JJ	_	8	conj	_	_
11	increase	increase	NN	NN	_	6	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	adhesion	adhesion	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	SS	ss	NN	NN	_	17	compound	_	_
17	RBC	rbc	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	PECAM-1	pecam-1	NN	NN	_	20	compound	_	_
20	phosphorylation	phosphorylation	NN	NN	_	11	conj	_	_
21	,	,	,	,	_	11	punct	_	_
22	and	and	CC	CC	_	11	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	concomitant	concomitant	JJ	JJ	_	26	amod	_	_
25	transendothelial	transendothelial	JJ	JJ	_	26	amod	_	_
26	migration	migration	NN	NN	_	11	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	26	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Impaired	impaired	JJ	JJ	_	2	amod	_	_
2	binding	binding	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	10	case	_	_
4	a	a	DT	DT	_	10	det	_	_
5	DQ2	dq2	NN	NN	_	10	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	DQ8-binding	dq8-binding	JJ	JJ	_	5	conj	_	_
8	HSV	hsv	NN	NN	_	10	compound	_	_
9	VP16	vp16	NN	NN	_	10	compound	_	_
10	peptide	peptide	NN	NN	_	2	nmod	_	_
11	to	to	TO	TO	_	17	case	_	_
12	a	a	DT	DT	_	17	det	_	_
13	DQA1*0501/DQB1*0302	dqa1*0501/dqb1*0302	NN	NN	_	17	compound	_	_
14	trans	trans	JJ	JJ	_	17	amod	_	_
15	class	class	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	17	nummod	_	_
17	heterodimer	heterodimer	NN	NN	_	2	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	DQalpha	dqalpha	NN	NN	_	7	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	DQbeta	dqbeta	NN	NN	_	1	conj	_	_
4	trans	trans	JJ	JJ	_	7	amod	_	_
5	heterodimeric	heterodimeric	JJ	JJ	_	7	amod	_	_
6	HLA-DQ	hla-dq	NN	NN	_	7	compound	_	_
7	molecules	molecule	NNS	NNS	_	8	nsubj	_	_
8	form	form	VBP	VBP	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	individuals	individual	NNS	NNS	_	8	nmod	_	_
11	heterozygous	heterozygous	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	DQ2	dq2	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	DQ8	dq8	NN	NN	_	14	conj	_	_
17	specificities	specificity	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Unique	unique	JJ	JJ	_	2	amod	_	_
2	functions	function	NNS	NNS	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	disease	disease	NN	NN	_	5	compound	_	_
5	associations	association	NNS	NNS	_	2	conj	_	_
6	have	have	VBP	VBP	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	aux	_	_
8	postulated	postulate	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	such	such	JJ	JJ	_	11	amod	_	_
11	trans-dimers	trans-dimer	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	which	which	WDT	WDT	_	16	nsubj	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	different	different	JJ	JJ	_	8	ccomp	_	_
17	from	from	IN	IN	_	20	case	_	_
18	cis-encoded	cis-encoded	JJ	JJ	_	20	amod	_	_
19	DQ	dq	NN	NN	_	20	compound	_	_
20	molecules	molecule	NNS	NNS	_	16	nmod	_	_
21	encoded	encode	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	corresponding	corresponding	JJ	JJ	_	25	amod	_	_
25	haplotypes	haplotype	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	analyzed	analyze	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	trans-dimer	trans-dimer	NN	NN	_	4	nmod	_	_
8	encoded	encode	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	HLA-DQA1*0501/DQB1*0302	hla-dqa1*0501/dqb1*0302	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	bind	bind	VB	VB	_	4	acl	_	_
13	a	a	DT	DT	_	15	det	_	_
14	peptide	peptide	NN	NN	_	15	compound	_	_
15	antigen	antigen	NN	NN	_	12	dobj	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	interacts	interact	VBZ	VBZ	_	15	acl:relcl	_	_
18	with	with	IN	IN	_	20	case	_	_
19	DQ	dq	NN	NN	_	20	compound	_	_
20	molecules	molecule	NNS	NNS	_	17	nmod	_	_
21	encoded	encode	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	25	case	_	_
23	both	both	DT	DT	_	25	det	_	_
24	parental	parental	JJ	JJ	_	25	amod	_	_
25	haplotypes	haplotype	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Markedly	markedly	RB	RB	_	2	advmod	_	_
2	impaired	impaired	JJ	JJ	_	3	amod	_	_
3	binding	binding	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	consistent	consistent	JJ	JJ	_	5	xcomp	_	_
8	with	with	IN	IN	_	7	nmod	_	_
9	both	both	CC	CC	_	8	dep	_	_
10	the	the	DT	DT	_	11	det	_	_
11	use	use	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	different	different	JJ	JJ	_	15	amod	_	_
14	anchor	anchor	NN	NN	_	15	compound	_	_
15	residues	residue	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	with	with	IN	IN	_	18	case	_	_
18	changes	change	NNS	NNS	_	8	conj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	levels	level	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	DQ	dq	NN	NN	_	24	compound	_	_
23	cis-dimer	cis-dimer	JJ	JJ	_	24	amod	_	_
24	availability	availability	NN	NN	_	20	nmod	_	_
25	for	for	IN	IN	_	28	case	_	_
26	peptide	peptide	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	interactions	interaction	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	neutrophil-endothelial	neutrophil-endothelial	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	adhesion	adhesion	NN	NN	_	2	nmod	_	_
7	induced	induce	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	redox	redox	NN	NN	_	10	compound	_	_
10	imbalance	imbalance	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	intracellular	intracellular	JJ	JJ	_	9	amod	_	_
9	thiols	thiol	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	factor-kappaB	factor-kappab	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	regulation	regulation	NN	NN	_	12	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	adhesion	adhesion	NN	NN	_	23	compound	_	_
23	molecules	molecule	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	designed	design	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	determine	determine	VB	VB	_	4	ccomp	_	_
7	whether	whether	IN	IN	_	23	mark	_	_
8	changes	change	NNS	NNS	_	23	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	glutathione	glutathione	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	GSH	gsh	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	or	or	CC	CC	_	12	cc	_	_
17	oxidized	oxidize	VBN	VBN	_	18	amod	_	_
18	glutathione	glutathione	NN	NN	_	12	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	GSSG	gssg	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	can	can	MD	MD	_	23	aux	_	_
23	alter	alter	VB	VB	_	6	ccomp	_	_
24	neutrophil	neutrophil	NN	NN	_	25	compound	_	_
25	adhesivity	adhesivity	NN	NN	_	23	dobj	_	_
26	and	and	CC	CC	_	6	cc	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	define	define	VB	VB	_	6	conj	_	_
29	the	the	DT	DT	_	31	det	_	_
30	molecular	molecular	JJ	JJ	_	31	amod	_	_
31	mechanism	mechanism	NN	NN	_	28	dobj	_	_
32	that	that	WDT	WDT	_	33	nsubj	_	_
33	underlies	underlie	VBZ	VBZ	_	31	acl:relcl	_	_
34	this	this	DT	DT	_	37	det	_	_
35	GSSG/GSH-induced	gssg/gsh-induced	JJ	JJ	_	37	amod	_	_
36	adhesion	adhesion	NN	NN	_	37	compound	_	_
37	response	response	NN	NN	_	33	dobj	_	_
38	.	.	.	.	_	4	punct	_	_

1	Treatment	treatment	NN	NN	_	27	nsubj	_	_
2	of	of	IN	IN	_	11	case	_	_
3	human	human	JJ	JJ	_	11	amod	_	_
4	umbilical	umbilical	JJ	JJ	_	11	amod	_	_
5	vein	vein	NN	NN	_	11	compound	_	_
6	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
7	cell	cell	NN	NN	_	11	compound	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	HUVEC	huvec	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	monolayers	monolayer	NNS	NNS	_	1	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	6	6	CD	CD	_	14	nummod	_	_
14	hours	hour	NNS	NNS	_	1	nmod	_	_
15	with	with	IN	IN	_	18	case	_	_
16	0.2	0.2	CD	CD	_	17	compound	_	_
17	mmol/L	mmol/l	NN	NN	_	18	amod	_	_
18	diamide	diamide	NN	NN	_	1	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	1	1	CD	CD	_	21	compound	_	_
21	mmol/L	mmol/l	NN	NN	_	23	amod	_	_
22	buthionine	buthionine	NN	NN	_	23	compound	_	_
23	sulfoximine	sulfoximine	NN	NN	_	18	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	BSO	bso	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	decreased	decrease	VBD	VBD	_	0	root	_	_
28	GSH	gsh	NN	NN	_	29	compound	_	_
29	levels	level	NNS	NNS	_	27	dobj	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	increased	increase	VBD	VBD	_	27	conj	_	_
32	the	the	DT	DT	_	33	det	_	_
33	ratio	ratio	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	GSSG	gssg	NN	NN	_	33	nmod	_	_
36	to	to	TO	TO	_	37	case	_	_
37	GSH	gsh	NN	NN	_	33	nmod	_	_
38	without	without	IN	IN	_	40	case	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	toxicity	toxicity	NN	NN	_	31	nmod	_	_
41	.	.	.	.	_	27	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	redox	redox	NN	NN	_	3	compound	_	_
3	changes	change	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	similar	similar	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	case	_	_
7	those	those	DT	DT	_	5	nmod	_	_
8	observed	observe	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	10	case	_	_
10	anoxia/reoxygenation	anoxia/reoxygenation	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	Diamide	diamide	NN	NN	_	5	compound	_	_
2	plus	plus	CC	CC	_	1	cc	_	_
3	BSO-induced	bso-induced	JJ	JJ	_	1	conj	_	_
4	thiol/disulfide	thiol/disulfide	NN	NN	_	5	compound	_	_
5	imbalance	imbalance	NN	NN	_	7	nsubjpass	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	biphasic	biphasic	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	neutrophil	neutrophil	NN	NN	_	14	compound	_	_
14	adhesion	adhesion	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	HUVECs	huvec	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	20	mark	_	_
18	peak	peak	JJ	JJ	_	19	amod	_	_
19	responses	response	NNS	NNS	_	20	nsubj	_	_
20	observed	observe	VBN	VBN	_	11	acl	_	_
21	at	at	IN	IN	_	23	case	_	_
22	15	15	CD	CD	_	23	nummod	_	_
23	minutes	minute	NNS	NNS	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	phase	phase	NN	NN	_	23	appos	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	)	)	-RRB-	-RRB-	_	25	punct	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	240	240	CD	CD	_	30	nummod	_	_
30	minutes	minute	NNS	NNS	_	23	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	phase	phase	NN	NN	_	30	appos	_	_
33	2	2	CD	CD	_	32	nummod	_	_
34	)	)	-RRB-	-RRB-	_	32	punct	_	_
35	.	.	.	.	_	7	punct	_	_

1	N-Acetylcysteine	n-acetylcysteine	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	attenuated	attenuate	VBD	VBD	_	0	root	_	_
4	neutrophil	neutrophil	NN	NN	_	5	compound	_	_
5	adhesion	adhesion	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	both	both	DT	DT	_	8	det	_	_
8	phases	phase	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	indicated	indicate	VBD	VBD	_	3	ccomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	for	for	IN	IN	_	15	case	_	_
15	GSH	gsh	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	adhesion	adhesion	NN	NN	_	19	compound	_	_
19	responses	response	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	phase	phase	NN	NN	_	5	compound	_	_
4	1	1	CD	CD	_	5	nummod	_	_
5	adhesion	adhesion	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	inversely	inversely	RB	RB	_	8	advmod	_	_
8	correlated	correlate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	GSH	gsh	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	8	nmod	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	11	cc	_	_
14	with	with	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	GSSG/GSH	gssg/gsh	NN	NN	_	17	compound	_	_
17	ratio	ratio	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	8	punct	_	_
19	whereas	whereas	IN	IN	_	8	dep	_	_
20	phase	phase	NN	NN	_	23	compound	_	_
21	2	2	CD	CD	_	23	nummod	_	_
22	neutrophil	neutrophil	NN	NN	_	23	compound	_	_
23	adhesion	adhesion	NN	NN	_	26	nsubjpass	_	_
24	was	be	VBD	VBD	_	26	auxpass	_	_
25	positively	positively	RB	RB	_	26	advmod	_	_
26	correlated	correlate	VBN	VBN	_	8	parataxis	_	_
27	with	with	IN	IN	_	29	case	_	_
28	GSSG/GSH	gssg/gsh	NN	NN	_	29	compound	_	_
29	ratio	ratio	NN	NN	_	26	nmod	_	_
30	but	but	CC	CC	_	31	cc	_	_
31	not	not	RB	RB	_	29	cc	_	_
32	with	with	IN	IN	_	34	case	_	_
33	GSH	gsh	NN	NN	_	34	compound	_	_
34	levels	level	NNS	NNS	_	29	conj	_	_
35	.	.	.	.	_	8	punct	_	_

1	Intercellular	intercellular	JJ	JJ	_	3	amod	_	_
2	adhesion	adhesion	NN	NN	_	3	compound	_	_
3	molecule-1	molecule-1	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	P-selectin-specific	p-selectin-specific	JJ	JJ	_	7	amod	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	antibodies	antibody	NNS	NNS	_	3	conj	_	_
8	attenuated	attenuate	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	12	det	_	_
10	increased	increase	VBN	VBN	_	12	amod	_	_
11	neutrophil	neutrophil	NN	NN	_	12	compound	_	_
12	adhesion	adhesion	NN	NN	_	8	dobj	_	_
13	during	during	IN	IN	_	15	case	_	_
14	both	both	DT	DT	_	15	det	_	_
15	phases	phase	NNS	NNS	_	8	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	whereas	whereas	IN	IN	_	8	dep	_	_
18	an	a	DT	DT	_	21	det	_	_
19	anti-E-selectin	anti-e-selectin	JJ	JJ	_	21	amod	_	_
20	monoclonal	monoclonal	JJ	JJ	_	21	amod	_	_
21	antibody	antibody	NN	NN	_	23	nsubj	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	attenuated	attenuate	VBD	VBD	_	8	parataxis	_	_
24	the	the	DT	DT	_	27	det	_	_
25	phase	phase	NN	NN	_	27	compound	_	_
26	2	2	CD	CD	_	27	nummod	_	_
27	response	response	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	8	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	22	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	actinomycin	actinomycin	NN	NN	_	4	compound	_	_
4	D	d	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	cycloheximide	cycloheximide	NN	NN	_	4	conj	_	_
7	or	or	CC	CC	_	4	cc	_	_
8	with	with	IN	IN	_	10	case	_	_
9	competing	compete	VBG	VBG	_	10	amod	_	_
10	ds-oligonucleotides	ds-oligonucleotide	NNS	NNS	_	4	conj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	contained	contain	VBD	VBD	_	10	acl:relcl	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	factor-kappaB	factor-kappab	NN	NN	_	12	dobj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	activator	activator	NN	NN	_	20	compound	_	_
17	protein-1	protein-1	NN	NN	_	20	compound	_	_
18	cognate	cognate	NN	NN	_	20	compound	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	sequences	sequence	NNS	NNS	_	14	conj	_	_
21	significantly	significantly	RB	RB	_	22	advmod	_	_
22	attenuated	attenuate	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	26	det	_	_
24	phase	phase	NN	NN	_	26	compound	_	_
25	2	2	CD	CD	_	26	nummod	_	_
26	response	response	NN	NN	_	22	dobj	_	_
27	,	,	,	,	_	22	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	implicated	implicate	VBD	VBD	_	22	ccomp	_	_
30	a	a	DT	DT	_	31	det	_	_
31	role	role	NN	NN	_	29	dobj	_	_
32	for	for	IN	IN	_	36	case	_	_
33	de	de	FW	FW	_	36	amod	_	_
34	novo	novo	FW	FW	_	33	dep	_	_
35	protein	protein	NN	NN	_	36	compound	_	_
36	synthesis	synthesis	NN	NN	_	31	nmod	_	_
37	.	.	.	.	_	22	punct	_	_

1	Surface	surface	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	intercellular	intercellular	JJ	JJ	_	6	amod	_	_
5	adhesion	adhesion	NN	NN	_	6	compound	_	_
6	molecule-1	molecule-1	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	P-selectin	p-selectin	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	E-selectin	e-selectin	NN	NN	_	6	conj	_	_
12	on	on	IN	IN	_	13	case	_	_
13	HUVECs	huvec	NNS	NNS	_	2	nmod	_	_
14	correlated	correlate	VBD	VBD	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	phase	phase	NN	NN	_	14	nmod	_	_
18	1	1	CD	CD	_	17	nummod	_	_
19	and	and	CC	CC	_	17	cc	_	_
20	2	2	CD	CD	_	23	nummod	_	_
21	neutrophil	neutrophil	NN	NN	_	23	compound	_	_
22	adhesion	adhesion	NN	NN	_	23	compound	_	_
23	responses	response	NNS	NNS	_	17	conj	_	_
24	.	.	.	.	_	14	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	changes	change	NNS	NNS	_	10	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	GSSG/GSH	gssg/gsh	NN	NN	_	5	nmod	_	_
10	cause	cause	VBP	VBP	_	3	ccomp	_	_
11	transcription-independent	transcription-independent	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	transcription-dependent	transcription-dependent	JJ	JJ	_	11	conj	_	_
14	surface	surface	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	10	dobj	_	_
16	of	of	IN	IN	_	21	case	_	_
17	different	different	JJ	JJ	_	21	amod	_	_
18	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	adhesion	adhesion	NN	NN	_	21	compound	_	_
21	molecules	molecule	NNS	NNS	_	15	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	leads	lead	VBZ	VBZ	_	15	acl:relcl	_	_
25	to	to	TO	TO	_	30	case	_	_
26	a	a	DT	DT	_	30	det	_	_
27	2-phase	2-phase	JJ	JJ	_	30	amod	_	_
28	neutrophil-endothelial	neutrophil-endothelial	JJ	JJ	_	30	amod	_	_
29	adhesion	adhesion	NN	NN	_	30	compound	_	_
30	response	response	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	MDS1/EVI1	mds1/evi1	NN	NN	_	2	nsubj	_	_
2	enhances	enhance	VBZ	VBZ	_	0	root	_	_
3	TGF-beta1	tgf-beta1	NN	NN	_	4	compound	_	_
4	signaling	signaling	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	strengthens	strengthen	VBZ	VBZ	_	2	conj	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	growth-inhibitory	growth-inhibitory	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	but	but	CC	CC	_	2	cc	_	_
11	the	the	DT	DT	_	15	det	_	_
12	leukemia-associated	leukemia-associated	JJ	JJ	_	15	amod	_	_
13	fusion	fusion	NN	NN	_	15	compound	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	22	nsubj	_	_
16	,	,	,	,	_	15	punct	_	_
17	product	product	NN	NN	_	15	appos	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	t(3;21)	t(3;21)	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	abrogates	abrogate	VBZ	VBZ	_	2	conj	_	_
23	growth-inhibition	growth-inhibition	NN	NN	_	22	dobj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	response	response	NN	NN	_	27	dep	_	_
26	to	to	TO	TO	_	27	case	_	_
27	TGF-beta1	tgf-beta1	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	MDS1/EVI1	mds1/evi1	NN	NN	_	10	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	located	located	JJ	JJ	_	1	amod	_	_
4	on	on	IN	IN	_	8	case	_	_
5	chromosome	chromosome	NN	NN	_	8	compound	_	_
6	3	3	CD	CD	_	8	nummod	_	_
7	band	band	NN	NN	_	8	compound	_	_
8	q26	q26	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	1	punct	_	_
10	encodes	encode	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	15	det	_	_
12	zinc-finger	zinc-finger	JJ	JJ	_	15	amod	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	activator	activator	NN	NN	_	10	dobj	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	detected	detect	VBN	VBN	_	15	dep	_	_
18	in	in	IN	IN	_	21	case	_	_
19	normal	normal	JJ	JJ	_	21	amod	_	_
20	hematopoietic	hematopoietic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	but	but	CC	CC	_	17	cc	_	_
23	expressed	express	VBN	VBN	_	17	conj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	several	several	JJ	JJ	_	27	amod	_	_
26	normal	normal	JJ	JJ	_	27	amod	_	_
27	tissues	tissue	NNS	NNS	_	23	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	MDS1/EVI1	mds1/evi1	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	inappropriately	inappropriately	RB	RB	_	4	advmod	_	_
4	activated	activate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	myeloid	myeloid	JJ	JJ	_	7	amod	_	_
7	leukemias	leukemia	NNS	NNS	_	4	nmod	_	_
8	following	follow	VBG	VBG	_	10	case	_	_
9	chromosomal	chromosomal	JJ	JJ	_	10	amod	_	_
10	rearrangements	rearrangement	NNS	NNS	_	4	nmod	_	_
11	involving	involve	VBG	VBG	_	10	acl	_	_
12	band	band	NN	NN	_	13	compound	_	_
13	3q26	3q26	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	rearrangements	rearrangement	NNS	NNS	_	3	nsubj	_	_
3	lead	lead	VBP	VBP	_	0	root	_	_
4	either	either	RB	RB	_	3	advmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	truncation	truncation	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	to	to	TO	TO	_	11	case	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	repressor	repressor	NN	NN	_	16	compound	_	_
16	EVI1	evi1	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	seen	see	VBN	VBN	_	3	advcl	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	t(3;3)(q21;q26)	t(3;3)(q21;q26)	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	inv(3)(q21q26)	inv(3)(q21q26)	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	3	punct	_	_
26	or	or	CC	CC	_	3	cc	_	_
27	to	to	TO	TO	_	29	case	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	fusion	fusion	NN	NN	_	3	conj	_	_
30	,	,	,	,	_	29	punct	_	_
31	as	as	IN	IN	_	32	mark	_	_
32	seen	see	VBN	VBN	_	29	advcl	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	t(3;21)(q26;q22)	t(3;21)(q26;q22)	NN	NN	_	32	nmod	_	_
36	which	which	WDT	WDT	_	37	nsubj	_	_
37	results	result	VBZ	VBZ	_	29	ccomp	_	_
38	in	in	IN	IN	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	fusion	fusion	NN	NN	_	42	compound	_	_
41	protein	protein	NN	NN	_	42	compound	_	_
42	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	37	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	fusion	fusion	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	4	nsubj	_	_
4	contains	contain	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	domain	domain	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	transcription	transcription	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	AML1	aml1	NN	NN	_	7	nmod	_	_
13	fused	fuse	VBN	VBN	_	12	acl	_	_
14	in-frame	in-frame	RB	RB	_	13	advmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	entire	entire	JJ	JJ	_	18	amod	_	_
18	MDS1/EVI1	mds1/evi1	NN	NN	_	13	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	exclusion	exclusion	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	27	case	_	_
23	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
24	first	first	JJ	JJ	_	27	amod	_	_
25	12	12	CD	CD	_	27	nummod	_	_
26	amino	amino	NN	NN	_	27	compound	_	_
27	acids	acid	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	analyzed	analyze	VBN	VBN	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	response	response	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	16	amod	_	_
13	precursor	precursor	NN	NN	_	16	compound	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	line	line	NN	NN	_	16	compound	_	_
16	32Dcl3	32dcl3	NN	NN	_	9	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	expressing	express	VBG	VBG	_	16	acl	_	_
19	either	either	CC	CC	_	23	cc:preconj	_	_
20	the	the	DT	DT	_	23	det	_	_
21	normal	normal	JJ	JJ	_	23	amod	_	_
22	protein	protein	NN	NN	_	23	compound	_	_
23	MDS1/EVI1	mds1/evi1	NN	NN	_	18	dobj	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	the	the	DT	DT	_	28	det	_	_
26	fusion	fusion	NN	NN	_	28	compound	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	23	conj	_	_
29	,	,	,	,	_	16	punct	_	_
30	to	to	TO	TO	_	31	case	_	_
31	factors	factor	NNS	NNS	_	9	nmod	_	_
32	that	that	WDT	WDT	_	33	nsubj	_	_
33	control	control	VBP	VBP	_	31	acl:relcl	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	differentiation	differentiation	NN	NN	_	33	dobj	_	_
36	or	or	CC	CC	_	35	cc	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	replication	replication	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	32Dcl3	32dcl3	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	5	nsubj	_	_
4	are	be	VBP	VBP	_	5	cop	_	_
5	IL-3-dependent	il-3-dependent	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	growth	growth	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	they	they	PRP	PRP	_	10	nsubj	_	_
10	differentiate	differentiate	VBP	VBP	_	5	conj	_	_
11	into	into	IN	IN	_	12	case	_	_
12	granulocytes	granulocyte	NNS	NNS	_	10	nmod	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	exposed	expose	VBN	VBN	_	10	advcl	_	_
15	to	to	TO	TO	_	16	case	_	_
16	G-CSF	g-csf	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	They	they	PRP	PRP	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	growth-inhibited	growth-inhibit	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	5	case	_	_
5	TGF-beta1	tgf-beta1	NN	NN	_	3	nmod	_	_
6	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	22	mark	_	_
4	whereas	whereas	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	MDS1/EVI1	mds1/evi1	NN	NN	_	6	nmod	_	_
9	has	have	VBZ	VBZ	_	22	advcl	_	_
10	no	no	DT	DT	_	11	neg	_	_
11	effect	effect	NN	NN	_	9	dobj	_	_
12	on	on	IN	IN	_	14	case	_	_
13	granulocytic	granulocytic	JJ	JJ	_	14	amod	_	_
14	differentiation	differentiation	NN	NN	_	9	nmod	_	_
15	induced	induce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	G-CSF	g-csf	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	expression	expression	NN	NN	_	22	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	19	nmod	_	_
22	blocks	block	VBZ	VBZ	_	2	ccomp	_	_
23	differentiation	differentiation	NN	NN	_	22	dobj	_	_
24	resulting	result	VBG	VBG	_	23	acl	_	_
25	in	in	IN	IN	_	27	case	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	death	death	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	similar	similar	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	that	that	DT	DT	_	4	nmod	_	_
7	previously	previously	RB	RB	_	8	advmod	_	_
8	described	describe	VBN	VBN	_	6	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	others	other	NNS	NNS	_	8	nmod	_	_
11	for	for	IN	IN	_	13	case	_	_
12	32Dcl3	32dcl3	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	express	express	VBP	VBP	_	13	acl:relcl	_	_
16	transgenic	transgenic	JJ	JJ	_	17	amod	_	_
17	Evil	evil	NN	NN	_	15	dobj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	34	mark	_	_
6	whereas	whereas	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	15	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	fusion	fusion	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	8	nmod	_	_
14	completely	completely	RB	RB	_	15	advmod	_	_
15	abrogates	abrogate	VBZ	VBZ	_	34	advcl	_	_
16	the	the	DT	DT	_	18	det	_	_
17	growth-inhibitory	growth-inhibitory	JJ	JJ	_	18	amod	_	_
18	effect	effect	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	TGF-beta1	tgf-beta1	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	allows	allow	VBZ	VBZ	_	15	conj	_	_
23	32Dcl3	32dcl3	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	22	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	proliferate	proliferate	VB	VB	_	22	xcomp	_	_
27	,	,	,	,	_	34	punct	_	_
28	expression	expression	NN	NN	_	34	nsubj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	normal	normal	JJ	JJ	_	33	amod	_	_
32	protein	protein	NN	NN	_	33	compound	_	_
33	MDS1/EVI1	mds1/evi1	NN	NN	_	28	nmod	_	_
34	has	have	VBZ	VBZ	_	4	ccomp	_	_
35	the	the	DT	DT	_	37	det	_	_
36	opposite	opposite	JJ	JJ	_	37	amod	_	_
37	effect	effect	NN	NN	_	34	dobj	_	_
38	,	,	,	,	_	34	punct	_	_
39	and	and	CC	CC	_	34	cc	_	_
40	it	it	PRP	PRP	_	41	nsubj	_	_
41	strengthens	strengthen	VBZ	VBZ	_	34	conj	_	_
42	the	the	DT	DT	_	43	det	_	_
43	response	response	NN	NN	_	41	dobj	_	_
44	of	of	IN	IN	_	45	case	_	_
45	cells	cell	NNS	NNS	_	43	nmod	_	_
46	to	to	TO	TO	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	growth-inhibitory	growth-inhibitory	JJ	JJ	_	49	amod	_	_
49	effect	effect	NN	NN	_	43	nmod	_	_
50	of	of	IN	IN	_	51	case	_	_
51	TGF-beta1	tgf-beta1	NN	NN	_	49	nmod	_	_
52	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	10	advcl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	yeast	yeast	NN	NN	_	6	compound	_	_
5	two-hybrid	two-hybrid	JJ	JJ	_	6	amod	_	_
6	system	system	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	10	punct	_	_
8	we	we	PRP	PRP	_	10	nsubj	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	24	mark	_	_
12	EVI1	evi1	NN	NN	_	24	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	12	punct	_	_
14	contained	contain	VBN	VBN	_	12	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	entirety	entirety	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	MDS1/EVI1	mds1/evi1	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	AML1/MDS1/EVI1	aml1/mds1/evi1	NN	NN	_	19	conj	_	_
22	)	)	-RRB-	-RRB-	_	12	punct	_	_
23	physically	physically	RB	RB	_	24	advmod	_	_
24	interacts	interact	VBZ	VBZ	_	10	ccomp	_	_
25	with	with	IN	IN	_	26	case	_	_
26	SMAD3	smad3	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	32	nsubj	_	_
29	is	be	VBZ	VBZ	_	32	cop	_	_
30	an	a	DT	DT	_	32	det	_	_
31	intracellular	intracellular	JJ	JJ	_	32	amod	_	_
32	mediator	mediator	NN	NN	_	26	acl:relcl	_	_
33	of	of	IN	IN	_	35	case	_	_
34	TGF-beta1	tgf-beta1	NN	NN	_	35	compound	_	_
35	signaling	signaling	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	correlated	correlate	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	response	response	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	G-CSF	g-csf	NN	NN	_	7	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	TGF-beta1	tgf-beta1	NN	NN	_	12	conj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	ability	ability	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	normal	normal	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	fusion	fusion	NN	NN	_	20	conj	_	_
23	proteins	protein	NNS	NNS	_	17	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	activate	activate	VB	VB	_	17	acl	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	repress	repress	VB	VB	_	25	conj	_	_
28	promoters	promoter	NNS	NNS	_	25	dobj	_	_
29	which	which	WDT	WDT	_	33	dobj	_	_
30	they	they	PRP	PRP	_	33	nsubj	_	_
31	can	can	MD	MD	_	33	aux	_	_
32	directly	directly	RB	RB	_	33	advmod	_	_
33	regulate	regulate	VB	VB	_	28	acl:relcl	_	_
34	by	by	IN	IN	_	35	case	_	_
35	binding	binding	NN	NN	_	33	advcl	_	_
36	to	to	TO	TO	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	promoter	promoter	NN	NN	_	39	compound	_	_
39	site	site	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	23	mark	_	_
4	mutations	mutation	NNS	NNS	_	23	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	MDS1/EVI1	mds1/evi1	NN	NN	_	4	nmod	_	_
7	either	either	CC	CC	_	10	cc:preconj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	truncation	truncation	NN	NN	_	4	nmod	_	_
11	resulting	result	VBG	VBG	_	10	acl	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	repressor	repressor	NN	NN	_	16	compound	_	_
16	EVI1	evi1	NN	NN	_	11	nmod	_	_
17	or	or	CC	CC	_	10	cc	_	_
18	by	by	IN	IN	_	20	case	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	fusion	fusion	NN	NN	_	10	conj	_	_
21	to	to	TO	TO	_	22	case	_	_
22	AML1	aml1	NN	NN	_	20	nmod	_	_
23	lead	lead	VBP	VBP	_	2	ccomp	_	_
24	to	to	TO	TO	_	28	case	_	_
25	an	a	DT	DT	_	28	det	_	_
26	altered	altered	JJ	JJ	_	28	amod	_	_
27	cellular	cellular	JJ	JJ	_	28	amod	_	_
28	response	response	NN	NN	_	23	nmod	_	_
29	to	to	TO	TO	_	33	case	_	_
30	growth	growth	NN	NN	_	33	compound	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	differentiation	differentiation	NN	NN	_	30	conj	_	_
33	factors	factor	NNS	NNS	_	28	nmod	_	_
34	that	that	WDT	WDT	_	36	nsubj	_	_
35	could	could	MD	MD	_	36	aux	_	_
36	result	result	VB	VB	_	33	acl:relcl	_	_
37	in	in	IN	IN	_	39	case	_	_
38	leukemic	leukemic	JJ	JJ	_	39	amod	_	_
39	transformation	transformation	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	20	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	ectopically	ectopically	RB	RB	_	8	advmod	_	_
8	expressing	express	VBG	VBG	_	6	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	normal	normal	JJ	JJ	_	8	dobj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	fusion	fusion	NN	NN	_	10	conj	_	_
14	protein	protein	NN	NN	_	10	dep	_	_
15	to	to	TO	TO	_	16	case	_	_
16	G-CSF	g-csf	NN	NN	_	3	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	TGF-beta1	tgf-beta1	NN	NN	_	16	conj	_	_
19	could	could	MD	MD	_	20	aux	_	_
20	depend	depend	VB	VB	_	0	root	_	_
21	on	on	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	different	different	JJ	JJ	_	25	amod	_	_
24	transactivation	transactivation	NN	NN	_	25	compound	_	_
25	properties	property	NNS	NNS	_	20	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	proteins	protein	NNS	NNS	_	25	nmod	_	_
29	resulting	result	VBG	VBG	_	25	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	divergent	divergent	JJ	JJ	_	32	amod	_	_
32	expression	expression	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	downstream	downstream	JJ	JJ	_	35	amod	_	_
35	genes	gene	NNS	NNS	_	32	nmod	_	_
36	regulated	regulate	VBN	VBN	_	32	acl	_	_
37	by	by	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	two	two	CD	CD	_	40	nummod	_	_
40	proteins	protein	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	20	punct	_	_

1	Interferon-alpha	interferon-alpha	NN	NN	_	2	compound	_	_
2	induction	induction	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	STATs1	stats1	NN	NN	_	8	compound	_	_
5	,	,	,	,	_	8	punct	_	_
6	-3	-3	CD	CD	_	8	nummod	_	_
7	DNA	dna	NN	NN	_	8	compound	_	_
8	binding	binding	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	growth	growth	NN	NN	_	11	compound	_	_
11	arrest	arrest	NN	NN	_	8	conj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	independent	independent	JJ	JJ	_	0	root	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Lck	lck	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	active	active	JJ	JJ	_	19	amod	_	_
18	mitogen-activated	mitogen-activated	JJ	JJ	_	19	amod	_	_
19	kinase	kinase	NN	NN	_	15	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Type	type	NN	NN	_	9	nsubj	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	interferons	interferon	NNS	NNS	_	1	dep	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IFNs	ifn	NNS	NNS	_	1	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	are	be	VBP	VBP	_	9	cop	_	_
8	a	a	DT	DT	_	9	det	_	_
9	family	family	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	have	have	VBP	VBP	_	11	acl:relcl	_	_
14	antiviral	antiviral	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	antiproliferative	antiproliferative	JJ	JJ	_	14	conj	_	_
17	effects	effect	NNS	NNS	_	13	dobj	_	_
18	.	.	.	.	_	9	punct	_	_

1	Data	datum	NNS	NNS	_	19	nsubj	_	_
2	regarding	regard	VBG	VBG	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	processes	process	NNS	NNS	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	9	nmod	_	_
7	these	these	DT	DT	_	8	det	_	_
8	cytokines	cytokine	NNS	NNS	_	9	nsubj	_	_
9	transduce	transduce	VBP	VBP	_	4	acl:relcl	_	_
10	signals	signal	NNS	NNS	_	9	dobj	_	_
11	from	from	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	membrane	membrane	NN	NN	_	10	nmod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	10	nmod	_	_
18	are	be	VBP	VBP	_	19	aux	_	_
19	becoming	become	VBG	VBG	_	0	root	_	_
20	increasingly	increasingly	RB	RB	_	21	advmod	_	_
21	complex	complex	JJ	JJ	_	19	xcomp	_	_
22	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	most	most	JJS	JJS	_	3	dep	_	_
3	characterized	characterize	VBN	VBN	_	4	amod	_	_
4	pathway	pathway	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	via	via	IN	IN	_	7	dep	_	_
7	JAK-STAT	jak-stat	NN	NN	_	8	amod	_	_
8	signaling	signaling	NN	NN	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	established	establish	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	potential	potential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	Src-family	src-family	NN	NN	_	11	compound	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	Lck	lck	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	JAK-STAT	jak-stat	NN	NN	_	14	amod	_	_
14	signaling	signaling	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Therefore	therefore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	designed	design	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	analyze	analyze	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	Lck	lck	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	IFN-alpha	ifn-alpha	NN	NN	_	15	compound	_	_
15	signaling	signaling	NN	NN	_	10	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	8	advcl	_	_
18	the	the	DT	DT	_	19	det	_	_
19	Jurkat	jurkat	NN	NN	_	17	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	JCam	jcam	NN	NN	_	19	conj	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	an	a	DT	DT	_	26	det	_	_
24	Lck-defective	lck-defective	JJ	JJ	_	26	amod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	21	dep	_	_
27	derived	derive	VBN	VBN	_	26	acl	_	_
28	from	from	IN	IN	_	29	case	_	_
29	Jurkat	jurkat	NN	NN	_	27	nmod	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	,	,	,	,	_	19	punct	_	_
32	and	and	CC	CC	_	19	cc	_	_
33	JCam/Lck	jcam/lck	NN	NN	_	19	conj	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	JCam	jcam	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	appos	_	_
37	with	with	IN	IN	_	39	mark	_	_
38	Lck	lck	NN	NN	_	39	nsubj	_	_
39	restored	restore	VBN	VBN	_	36	acl:relcl	_	_
40	)	)	-RRB-	-RRB-	_	36	punct	_	_
41	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	IFN-alpha	ifn-alpha	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	induce	induce	VB	VB	_	3	ccomp	_	_
8	MAPK	mapk	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	only	only	RB	RB	_	14	advmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	cells	cell	NNS	NNS	_	7	conj	_	_
15	containing	contain	VBG	VBG	_	14	acl	_	_
16	Lck	lck	NN	NN	_	15	dobj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	STATs1	stats1	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	-3	-3	CD	CD	_	3	conj	_	_
6	are	be	VBP	VBP	_	8	aux	_	_
7	effectively	effectively	RB	RB	_	8	advmod	_	_
8	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	activated	activate	VBN	VBN	_	8	conj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	bind	bind	VB	VB	_	8	xcomp	_	_
13	DNA	dna	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	dep	_	_
16	absence	absence	NN	NN	_	19	dep	_	_
17	of	of	IN	IN	_	19	case	_	_
18	Lck	lck	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	12	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	IFN-alpha-treated	ifn-alpha-treated	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	IFN-alpha	ifn-alpha	NN	NN	_	8	nsubj	_	_
8	exerts	exert	VBZ	VBZ	_	5	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	antiproliferative	antiproliferative	JJ	JJ	_	11	amod	_	_
11	effect	effect	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	all	all	DT	DT	_	16	det	_	_
14	three	three	CD	CD	_	16	nummod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lines	line	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	Lck	lck	NN	NN	_	11	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	active	active	JJ	JJ	_	8	amod	_	_
8	MAPK	mapk	NN	NN	_	5	conj	_	_
9	do	do	VBP	VBP	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	affect	affect	VB	VB	_	3	ccomp	_	_
12	IFN-alpha-induced	ifn-alpha-induced	JJ	JJ	_	14	amod	_	_
13	growth	growth	NN	NN	_	14	compound	_	_
14	arrest	arrest	NN	NN	_	11	dobj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	induction	induction	NN	NN	_	14	conj	_	_
17	of	of	IN	IN	_	23	case	_	_
18	STAT1s1	stat1s1	NN	NN	_	23	compound	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	-3	-3	CD	CD	_	18	conj	_	_
21	DNA	dna	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	ability	ability	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Decreased	decrease	VBN	VBN	_	3	amod	_	_
2	proteasome-mediated	proteasome-mediated	JJ	JJ	_	3	amod	_	_
3	degradation	degradation	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	from	from	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	elderly	elderly	JJ	JJ	_	6	nmod	_	_
10	:	:	:	:	_	3	punct	_	_
11	A	a	DT	DT	_	12	det	_	_
12	role	role	NN	NN	_	3	dep	_	_
13	in	in	IN	IN	_	15	case	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	senescence	senescence	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NFkappaB	nfkappab	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	regulated	regulate	VBN	VBN	_	8	amod	_	_
8	process	process	NN	NN	_	0	root	_	_
9	requiring	require	VBG	VBG	_	8	acl	_	_
10	phosphorylation	phosphorylation	NN	NN	_	9	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	ubiquitination	ubiquitination	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	proteasome-mediated	proteasome-mediated	JJ	JJ	_	16	amod	_	_
16	degradation	degradation	NN	NN	_	10	conj	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	cytosolic	cytosolic	JJ	JJ	_	21	amod	_	_
20	inhibitor	inhibitor	NN	NN	_	21	compound	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	10	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	Analyses	analysis	NNS	NNS	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	regulation	regulation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IkappaBalpha	ikappabalpha	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	TNF-alpha-treated	tnf-alpha-treated	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	from	from	IN	IN	_	15	case	_	_
12	young	young	JJ	JJ	_	15	amod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	elderly	elderly	JJ	JJ	_	12	conj	_	_
15	donors	donor	NNS	NNS	_	10	nmod	_	_
16	revealed	reveal	VBD	VBD	_	0	root	_	_
17	severely	severely	RB	RB	_	18	advmod	_	_
18	compromised	compromise	VBN	VBN	_	19	amod	_	_
19	degradation	degradation	NN	NN	_	16	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	from	from	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	elderly	elderly	JJ	JJ	_	24	nmod	_	_
28	.	.	.	.	_	16	punct	_	_

1	Examination	examination	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	activation-induced	activation-induced	JJ	JJ	_	4	amod	_	_
4	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	ubiquitination	ubiquitination	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IkappaBalpha	ikappabalpha	NN	NN	_	4	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	demonstrate	demonstrate	VB	VB	_	0	root	_	_
12	any	any	DT	DT	_	15	det	_	_
13	significant	significant	JJ	JJ	_	15	amod	_	_
14	age-related	age-related	JJ	JJ	_	15	amod	_	_
15	alterations	alteration	NNS	NNS	_	11	dobj	_	_
16	.	.	.	.	_	11	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	examination	examination	NN	NN	_	15	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	proteasome	proteasome	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	these	these	DT	DT	_	10	det	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	using	use	VBG	VBG	_	3	acl	_	_
12	fluorogenic	fluorogenic	JJ	JJ	_	14	amod	_	_
13	peptide	peptide	NN	NN	_	14	compound	_	_
14	assays	assay	NNS	NNS	_	11	dobj	_	_
15	revealed	reveal	VBD	VBD	_	0	root	_	_
16	a	a	DT	DT	_	19	det	_	_
17	significant	significant	JJ	JJ	_	19	amod	_	_
18	age-related	age-related	JJ	JJ	_	19	amod	_	_
19	decline	decline	NN	NN	_	15	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	chymotryptic	chymotryptic	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	a	a	DT	DT	_	6	det	_	_
6	decline	decline	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	proteasome	proteasome	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	results	result	VBZ	VBZ	_	3	ccomp	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	failure	failure	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	fully	fully	RB	RB	_	16	advmod	_	_
16	degrade	degrade	VB	VB	_	13	acl	_	_
17	IkappaBalpha	ikappabalpha	NN	NN	_	16	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	elderly	elderly	JJ	JJ	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	failure	failure	NN	NN	_	7	nsubj	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	degrade	degrade	VB	VB	_	2	acl	_	_
5	IkappaBalpha	ikappabalpha	NN	NN	_	4	dobj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	underlie	underlie	VB	VB	_	0	root	_	_
8	both	both	CC	CC	_	11	cc:preconj	_	_
9	the	the	DT	DT	_	11	det	_	_
10	observed	observe	VBN	VBN	_	11	amod	_	_
11	decrease	decrease	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	NFkappaB	nfkappab	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	the	the	DT	DT	_	19	det	_	_
17	IL-2	il-2	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	11	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	TNF-treated	tnf-treated	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	during	during	IN	IN	_	25	case	_	_
25	aging	aging	NN	NN	_	11	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	decreased	decrease	VBN	VBN	_	5	amod	_	_
4	proteasome-mediated	proteasome-mediated	JJ	JJ	_	5	amod	_	_
5	degradation	degradation	NN	NN	_	8	nsubj	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	central	central	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	dysfunction	dysfunction	NN	NN	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	accompanies	accompany	VBZ	VBZ	_	11	acl:relcl	_	_
14	aging	aging	NN	NN	_	13	dobj	_	_
15	.	.	.	.	_	8	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	helper	helper	NN	NN	_	3	compound	_	_
3	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
4	proceeds	proceed	VBZ	VBZ	_	0	root	_	_
5	through	through	IN	IN	_	11	case	_	_
6	Stat1-dependent	stat1-dependent	JJ	JJ	_	11	amod	_	_
7	,	,	,	,	_	6	punct	_	_
8	Stat4-dependent	stat4-dependent	JJ	JJ	_	6	conj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	Stat4-independent	stat4-independent	JJ	JJ	_	6	conj	_	_
11	phases	phase	NNS	NNS	_	4	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Much	much	JJ	JJ	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	focus	focus	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	understanding	understand	VBG	VBG	_	4	acl	_	_
7	Th1/Th2	th1/th2	NN	NN	_	8	compound	_	_
8	development	development	NN	NN	_	6	dobj	_	_
9	has	have	VBZ	VBZ	_	13	aux	_	_
10	been	be	VBN	VBN	_	13	cop	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	signals	signal	NNS	NNS	_	0	root	_	_
14	delivered	deliver	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	IL-12	il-12	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-4	il-4	NN	NN	_	16	conj	_	_
19	as	as	IN	IN	_	21	case	_	_
20	final	final	JJ	JJ	_	21	amod	_	_
21	determinants	determinant	NNS	NNS	_	14	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	terminal	terminal	JJ	JJ	_	26	amod	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	differentiation	differentiation	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	13	punct	_	_

1	Because	because	IN	IN	_	13	mark	_	_
2	extinction	extinction	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	IL-12	il-12	NN	NN	_	5	compound	_	_
5	signaling	signaling	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	early	early	JJ	JJ	_	9	amod	_	_
8	Th2	th2	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	2	nmod	_	_
10	could	could	MD	MD	_	13	aux	_	_
11	potentially	potentially	RB	RB	_	13	advmod	_	_
12	be	be	VB	VB	_	13	cop	_	_
13	important	important	JJ	JJ	_	31	advcl	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	imprinting	imprint	VBG	VBG	_	13	advcl	_	_
16	a	a	DT	DT	_	20	det	_	_
17	more	more	RBR	RBR	_	18	advmod	_	_
18	permanent	permanent	JJ	JJ	_	20	amod	_	_
19	Th2	th2	NN	NN	_	20	compound	_	_
20	phenotype	phenotype	NN	NN	_	15	dobj	_	_
21	on	on	IN	IN	_	23	case	_	_
22	a	a	DT	DT	_	23	det	_	_
23	population	population	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	,	,	,	,	_	31	punct	_	_
28	we	we	PRP	PRP	_	31	nsubj	_	_
29	have	have	VBP	VBP	_	31	aux	_	_
30	also	also	RB	RB	_	31	advmod	_	_
31	examined	examine	VBN	VBN	_	0	root	_	_
32	various	various	JJ	JJ	_	33	amod	_	_
33	parameters	parameter	NNS	NNS	_	31	dobj	_	_
34	regulating	regulate	VBG	VBG	_	33	acl	_	_
35	the	the	DT	DT	_	38	det	_	_
36	IL-12	il-12	NN	NN	_	38	compound	_	_
37	signaling	signaling	NN	NN	_	38	compound	_	_
38	pathway	pathway	NN	NN	_	34	dobj	_	_
39	.	.	.	.	_	31	punct	_	_

1	Whereas	whereas	IN	IN	_	3	mark	_	_
2	IL-4	il-4	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	27	advcl	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	repress	repress	VB	VB	_	3	xcomp	_	_
6	functional	functional	JJ	JJ	_	8	amod	_	_
7	IL-12	il-12	NN	NN	_	8	compound	_	_
8	signaling	signaling	NN	NN	_	5	dobj	_	_
9	through	through	IN	IN	_	10	case	_	_
10	inhibition	inhibition	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	IL-12R	il-12r	NN	NN	_	15	compound	_	_
13	beta	beta	NN	NN	_	15	compound	_	_
14	2	2	CD	CD	_	15	nummod	_	_
15	expression	expression	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	27	punct	_	_
17	IFN-gamma	ifn-gamma	NN	NN	_	27	nsubj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	mouse	mouse	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	IFN-alpha	ifn-alpha	NN	NN	_	17	conj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	human	human	JJ	JJ	_	23	nmod	_	_
27	appear	appear	VBP	VBP	_	0	root	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	induce	induce	VB	VB	_	27	xcomp	_	_
30	IL-12R	il-12r	NN	NN	_	33	compound	_	_
31	beta	beta	NN	NN	_	33	compound	_	_
32	2	2	CD	CD	_	33	nummod	_	_
33	expression	expression	NN	NN	_	29	dobj	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	promote	promote	VBP	VBP	_	29	conj	_	_
36	IL-12	il-12	NN	NN	_	37	compound	_	_
37	responsiveness	responsiveness	NN	NN	_	35	dobj	_	_
38	.	.	.	.	_	27	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	Th1	th1	NN	NN	_	5	compound	_	_
5	development	development	NN	NN	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	considered	consider	VBN	VBN	_	2	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	stages	stage	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	capacitance	capacitance	NN	NN	_	11	appos	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	development	development	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Capacitance	capacitance	NN	NN	_	4	nsubj	_	_
2	would	would	MD	MD	_	4	aux	_	_
3	simply	simply	RB	RB	_	4	advmod	_	_
4	involve	involve	VB	VB	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	IL-12R	il-12r	NN	NN	_	13	compound	_	_
8	beta	beta	NN	NN	_	13	compound	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	beta	beta	NN	NN	_	8	conj	_	_
12	2	2	CD	CD	_	11	nummod	_	_
13	subunits	subunit	NNS	NNS	_	5	nmod	_	_
14	,	,	,	,	_	15	punct	_	_
15	regulated	regulate	VBN	VBN	_	13	dep	_	_
16	by	by	IN	IN	_	17	case	_	_
17	TCR	tcr	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	15	punct	_	_
19	IL-4	il-4	NN	NN	_	13	conj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	IFNs	ifn	NNS	NNS	_	13	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	stage	stage	NN	NN	_	8	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	development	development	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	propose	propose	VBP	VBP	_	0	root	_	_
9	is	be	VBZ	VBZ	_	15	cop	_	_
10	the	the	DT	DT	_	15	det	_	_
11	true	true	JJ	JJ	_	15	amod	_	_
12	IL-12	il-12	NN	NN	_	15	compound	_	_
13	induced	induced	JJ	JJ	_	15	amod	_	_
14	developmental	developmental	JJ	JJ	_	15	amod	_	_
15	stage	stage	NN	NN	_	8	ccomp	_	_
16	,	,	,	,	_	15	punct	_	_
17	involving	involve	VBG	VBG	_	18	case	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	Stat4	stat4	NN	NN	_	22	compound	_	_
21	inducible	inducible	JJ	JJ	_	22	amod	_	_
22	proteins	protein	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	human	human	JJ	JJ	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	this	this	DT	DT	_	8	nsubj	_	_
6	may	may	MD	MD	_	8	aux	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	occur	occur	VB	VB	_	0	root	_	_
9	via	via	IN	IN	_	10	case	_	_
10	IFN-alpha	ifn-alpha	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	is	be	VBZ	VBZ	_	14	cop	_	_
14	able	able	JJ	JJ	_	8	ccomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	activate	activate	VB	VB	_	14	xcomp	_	_
17	Stat4	stat4	NN	NN	_	16	dobj	_	_
18	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	perhaps	perhaps	RB	RB	_	4	advmod	_	_
4	possible	possible	JJ	JJ	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	all	all	DT	DT	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	Stat4	stat4	NN	NN	_	9	compound	_	_
9	actions	action	NNS	NNS	_	6	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	Th1	th1	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	9	nmod	_	_
13	may	may	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	exert	exert	VBN	VBN	_	4	ccomp	_	_
16	directly	directly	RB	RB	_	15	advmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	Stat4	stat4	NN	NN	_	15	nmod	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	gene	gene	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	4	punct	_	_
24	however	however	RB	RB	_	26	advmod	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	suggest	suggest	VBP	VBP	_	4	parataxis	_	_
27	that	that	IN	IN	_	34	mark	_	_
28	,	,	,	,	_	34	punct	_	_
29	more	more	RBR	RBR	_	30	advmod	_	_
30	likely	likely	JJ	JJ	_	34	advmod	_	_
31	,	,	,	,	_	34	punct	_	_
32	Stat4	stat4	NN	NN	_	34	nsubj	_	_
33	may	may	MD	MD	_	34	aux	_	_
34	act	act	VB	VB	_	26	ccomp	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	induce	induce	VB	VB	_	34	xcomp	_	_
37	Th1	th1	NN	NN	_	38	compound	_	_
38	development	development	NN	NN	_	36	dobj	_	_
39	through	through	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	induction	induction	NN	NN	_	36	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	other	other	JJ	JJ	_	45	amod	_	_
44	non-cytokine	non-cytokine	JJ	JJ	_	45	amod	_	_
45	genes	gene	NNS	NNS	_	41	nmod	_	_
46	,	,	,	,	_	45	punct	_	_
47	whose	whose	WP$	WP$	_	49	nmod:poss	_	_
48	stable	stable	JJ	JJ	_	49	amod	_	_
49	expression	expression	NN	NN	_	50	nsubj	_	_
50	maintains	maintain	VBZ	VBZ	_	45	acl:relcl	_	_
51	the	the	DT	DT	_	53	det	_	_
52	transcriptional	transcriptional	JJ	JJ	_	53	amod	_	_
53	state	state	NN	NN	_	50	dobj	_	_
54	of	of	IN	IN	_	57	case	_	_
55	a	a	DT	DT	_	57	det	_	_
56	Th1	th1	NN	NN	_	57	compound	_	_
57	cell	cell	NN	NN	_	53	nmod	_	_
58	.	.	.	.	_	4	punct	_	_

1	Identification	identification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	upstream	upstream	JJ	JJ	_	5	amod	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	repress	repress	VBP	VBP	_	5	acl:relcl	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	adult	adult	JJ	JJ	_	13	amod	_	_
11	beta-like	beta-like	JJ	JJ	_	13	amod	_	_
12	globin	globin	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	8	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	primitive	primitive	JJ	JJ	_	18	amod	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	environment	environment	NN	NN	_	8	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	investigations	investigation	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	focused	focus	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	6	mark	_	_
6	localizing	localize	VBG	VBG	_	4	advcl	_	_
7	cis-elements	cis-element	NNS	NNS	_	6	dobj	_	_
8	responsible	responsible	JJ	JJ	_	7	amod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	down	down	JJ	JJ	_	12	amod	_	_
12	regulation	regulation	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	adult	adult	JJ	JJ	_	18	amod	_	_
16	beta-like	beta-like	JJ	JJ	_	18	amod	_	_
17	globin	globin	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	delta	delta	NN	NN	_	18	dep	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	beta	beta	NN	NN	_	20	conj	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	in	in	IN	IN	_	30	case	_	_
25	immature	immature	JJ	JJ	_	30	amod	_	_
26	,	,	,	,	_	25	punct	_	_
27	or	or	CC	CC	_	25	cc	_	_
28	primitive	primitive	JJ	JJ	_	25	conj	_	_
29	erythroid	erythroid	JJ	JJ	_	30	amod	_	_
30	tissues	tissue	NNS	NNS	_	18	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	studied	study	VBD	VBD	_	0	root	_	_
3	their	they	PRP$	PRP$	_	4	nmod:poss	_	_
4	activity	activity	NN	NN	_	2	dobj	_	_
5	after	after	IN	IN	_	6	case	_	_
6	transfection	transfection	NN	NN	_	2	nmod	_	_
7	into	into	IN	IN	_	9	case	_	_
8	K562	k562	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	an	a	DT	DT	_	14	det	_	_
12	erythroleukemia	erythroleukemia	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	9	appos	_	_
15	with	with	IN	IN	_	18	case	_	_
16	an	a	DT	DT	_	18	det	_	_
17	embryonic-fetal	embryonic-fetal	JJ	JJ	_	18	amod	_	_
18	phenotype	phenotype	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Analyzed	analyze	VBN	VBN	_	3	amod	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	sequences	sequence	NNS	NNS	_	4	nsubj	_	_
4	included	include	VBD	VBD	_	0	root	_	_
5	delta	delta	NN	NN	_	10	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	beta	beta	NN	NN	_	5	conj	_	_
8	5'	5'	JJ	JJ	_	10	amod	_	_
9	flanking	flanking	NN	NN	_	10	compound	_	_
10	regions	region	NNS	NNS	_	4	dobj	_	_
11	extending	extend	VBG	VBG	_	10	acl	_	_
12	from	from	IN	IN	_	14	case	_	_
13	approximately	approximately	RB	RB	_	14	advmod	_	_
14	-500	-500	CD	CD	_	11	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	+50bp	+50bp	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	regions	region	NNS	NNS	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	4	punct	_	_
22	truncated	truncated	JJ	JJ	_	4	dep	_	_
23	delta	delta	NN	NN	_	28	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	beta	beta	NN	NN	_	23	conj	_	_
26	5'	5'	JJ	JJ	_	28	amod	_	_
27	flanking	flanking	NN	NN	_	28	compound	_	_
28	regions	region	NNS	NNS	_	22	dobj	_	_
29	extending	extend	VBG	VBG	_	28	acl	_	_
30	from	from	IN	IN	_	32	case	_	_
31	approximately	approximately	RB	RB	_	32	advmod	_	_
32	-250	-250	CD	CD	_	29	nmod	_	_
33	to	to	TO	TO	_	35	case	_	_
34	+50	+50	CD	CD	_	35	nummod	_	_
35	bp	bp	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	28	punct	_	_
37	and	and	CC	CC	_	28	cc	_	_
38	chimeric	chimeric	JJ	JJ	_	40	amod	_	_
39	promoter	promoter	NN	NN	_	40	compound	_	_
40	constructions	construction	NNS	NNS	_	28	conj	_	_
41	,	,	,	,	_	40	punct	_	_
42	which	which	WDT	WDT	_	43	nsubj	_	_
43	consisted	consist	VBD	VBD	_	40	acl:relcl	_	_
44	of	of	IN	IN	_	47	case	_	_
45	a	a	DT	DT	_	47	det	_	_
46	distal	distal	JJ	JJ	_	47	amod	_	_
47	delta	delta	NN	NN	_	43	nmod	_	_
48	or	or	CC	CC	_	47	cc	_	_
49	beta	beta	NN	NN	_	50	compound	_	_
50	fragment	fragment	NN	NN	_	47	conj	_	_
51	fused	fuse	VBN	VBN	_	47	acl	_	_
52	to	to	TO	TO	_	55	case	_	_
53	a	a	DT	DT	_	55	det	_	_
54	proximal	proximal	JJ	JJ	_	55	amod	_	_
55	beta	beta	NN	NN	_	51	nmod	_	_
56	or	or	CC	CC	_	55	cc	_	_
57	delta	delta	NN	NN	_	58	compound	_	_
58	sequence	sequence	NN	NN	_	55	conj	_	_
59	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	CAT	cat	NN	NN	_	4	compound	_	_
3	reporter	reporter	NN	NN	_	4	compound	_	_
4	constructions	construction	NNS	NNS	_	12	nmod	_	_
5	no	no	DT	DT	_	7	neg	_	_
6	appreciable	appreciable	JJ	JJ	_	7	amod	_	_
7	level	level	NN	NN	_	12	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	CAT	cat	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	supported	support	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	beta	beta	NN	NN	_	17	compound	_	_
16	globin	globin	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	only	only	RB	RB	_	23	advmod	_	_
21	low	low	JJ	JJ	_	22	dep	_	_
22	level	level	NN	NN	_	23	amod	_	_
23	activity	activity	NN	NN	_	12	conj	_	_
24	by	by	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	delta	delta	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	23	dep	_	_
28	.	.	.	.	_	12	punct	_	_

1	Truncation	truncation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	beta	beta	NN	NN	_	6	compound	_	_
5	globin	globin	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	1	nmod	_	_
7	led	lead	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	a	a	DT	DT	_	12	det	_	_
10	2-3	2-3	CD	CD	_	11	compound	_	_
11	fold	fold	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	deletion	deletion	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	upstream	upstream	JJ	JJ	_	8	amod	_	_
8	portion	portion	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	delta	delta	NN	NN	_	12	compound	_	_
12	promoter	promoter	NN	NN	_	8	nmod	_	_
13	led	lead	VBD	VBD	_	0	root	_	_
14	to	to	TO	TO	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	10	10	CD	CD	_	17	compound	_	_
17	fold	fold	JJ	JJ	_	18	amod	_	_
18	decrease	decrease	NN	NN	_	13	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	expression	expression	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Coupling	coupling	NN	NN	_	20	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	upstream	upstream	JJ	JJ	_	7	amod	_	_
5	beta	beta	NN	NN	_	7	compound	_	_
6	globin	globin	NN	NN	_	7	compound	_	_
7	sequence	sequence	NN	NN	_	1	nmod	_	_
8	from	from	IN	IN	_	12	advmod	_	_
9	approximately	approximately	RB	RB	_	12	advmod	_	_
10	-500	-500	CD	CD	_	12	compound	_	_
11	to	to	TO	TO	_	12	dep	_	_
12	-250	-250	CD	CD	_	13	nummod	_	_
13	bp	bp	NN	NN	_	7	dep	_	_
14	to	to	TO	TO	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	truncated	truncate	VBN	VBN	_	19	amod	_	_
17	delta	delta	NN	NN	_	19	compound	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	fragment	fragment	NN	NN	_	1	nmod	_	_
20	led	lead	VBD	VBD	_	0	root	_	_
21	to	to	TO	TO	_	23	case	_	_
22	complete	complete	JJ	JJ	_	23	amod	_	_
23	extinction	extinction	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	20	punct	_	_
28	consistent	consistent	JJ	JJ	_	20	xcomp	_	_
29	with	with	IN	IN	_	33	case	_	_
30	a	a	DT	DT	_	33	det	_	_
31	negative	negative	JJ	JJ	_	33	amod	_	_
32	regulatory	regulatory	JJ	JJ	_	33	amod	_	_
33	effect	effect	NN	NN	_	28	nmod	_	_
34	of	of	IN	IN	_	42	case	_	_
35	the	the	DT	DT	_	42	det	_	_
36	beta	beta	NN	NN	_	42	compound	_	_
37	globin	globin	NN	NN	_	42	compound	_	_
38	gene	gene	NN	NN	_	42	compound	_	_
39	upstream	upstream	JJ	JJ	_	42	amod	_	_
40	element	element	NN	NN	_	42	compound	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	s	s	NNS	NNS	_	33	nmod	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	20	punct	_	_

1	Fusion	fusion	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	upstream	upstream	JJ	JJ	_	5	amod	_	_
5	portion	portion	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	delta	delta	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	to	to	TO	TO	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	truncated	truncate	VBN	VBN	_	15	amod	_	_
13	beta	beta	NN	NN	_	15	compound	_	_
14	globin	globin	NN	NN	_	15	compound	_	_
15	promoter	promoter	NN	NN	_	1	nmod	_	_
16	yielded	yield	VBD	VBD	_	0	root	_	_
17	a	a	DT	DT	_	19	det	_	_
18	modest	modest	JJ	JJ	_	19	amod	_	_
19	increase	increase	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	strength	strength	NN	NN	_	19	nmod	_	_
23	relative	relative	JJ	JJ	_	29	case	_	_
24	to	to	TO	TO	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	truncated	truncate	VBN	VBN	_	29	amod	_	_
27	beta	beta	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	19	nmod	_	_
30	,	,	,	,	_	16	punct	_	_
31	indicating	indicate	VBG	VBG	_	16	advcl	_	_
32	the	the	DT	DT	_	33	det	_	_
33	presence	presence	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	40	case	_	_
35	a	a	DT	DT	_	40	det	_	_
36	positive	positive	JJ	JJ	_	40	amod	_	_
37	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
38	element	element	NN	NN	_	40	compound	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	s	s	NNS	NNS	_	33	nmod	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	in	in	IN	IN	_	48	case	_	_
43	the	the	DT	DT	_	48	det	_	_
44	upstream	upstream	JJ	JJ	_	48	amod	_	_
45	delta	delta	NN	NN	_	48	compound	_	_
46	globin	globin	NN	NN	_	48	compound	_	_
47	regulatory	regulatory	JJ	JJ	_	48	amod	_	_
48	region	region	NN	NN	_	33	nmod	_	_
49	.	.	.	.	_	16	punct	_	_

1	Site-directed	site-directed	JJ	JJ	_	2	amod	_	_
2	mutagenesis	mutagenesis	NN	NN	_	24	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	2	nmod	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	repressor	repressor	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	5	nmod	_	_
10	BP1	bp1	NN	NN	_	9	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	BP2	bp2	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	upstream	upstream	JJ	JJ	_	16	amod	_	_
16	portion	portion	NN	NN	_	2	nmod	_	_
17	of	of	IN	IN	_	23	case	_	_
18	the	the	DT	DT	_	23	det	_	_
19	beta	beta	NN	NN	_	23	compound	_	_
20	globin	globin	NN	NN	_	23	compound	_	_
21	gene	gene	NN	NN	_	23	compound	_	_
22	flanking	flanking	NN	NN	_	23	compound	_	_
23	region	region	NN	NN	_	16	nmod	_	_
24	led	lead	VBD	VBD	_	0	root	_	_
25	to	to	TO	TO	_	29	case	_	_
26	a	a	DT	DT	_	29	det	_	_
27	4-6	4-6	CD	CD	_	28	compound	_	_
28	fold	fold	JJ	JJ	_	29	amod	_	_
29	increase	increase	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	promoter	promoter	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	DNase	dnase	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	3	nummod	_	_
3	footprinting	footprinting	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	upstream	upstream	JJ	JJ	_	8	amod	_	_
7	delta-globin	delta-globin	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	3	nmod	_	_
9	revealed	reveal	VBD	VBD	_	0	root	_	_
10	protected	protected	JJ	JJ	_	11	amod	_	_
11	sequences	sequence	NNS	NNS	_	9	dobj	_	_
12	corresponding	correspond	VBG	VBG	_	11	acl	_	_
13	to	to	TO	TO	_	16	case	_	_
14	consensus	consensus	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	12	nmod	_	_
17	for	for	IN	IN	_	18	case	_	_
18	GATA-1	gata-1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	BP2	bp2	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	confirm	confirm	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	sequences	sequence	NNS	NNS	_	17	nsubj	_	_
6	in	in	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	upstream	upstream	JJ	JJ	_	10	amod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	region	region	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	adult	adult	JJ	JJ	_	16	amod	_	_
14	beta	beta	NN	NN	_	16	compound	_	_
15	globin	globin	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	contribute	contribute	VBP	VBP	_	3	ccomp	_	_
18	to	to	TO	TO	_	21	case	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	factor-mediated	factor-mediated	JJ	JJ	_	21	amod	_	_
21	suppression	suppression	NN	NN	_	17	nmod	_	_
22	early	early	JJ	JJ	_	24	advmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	development	development	NN	NN	_	17	nmod	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	then	then	RB	RB	_	28	advmod	_	_
27	may	may	MD	MD	_	28	aux	_	_
28	modulate	modulate	VB	VB	_	17	conj	_	_
29	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
30	expression	expression	NN	NN	_	28	dobj	_	_
31	at	at	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	later	later	JJ	JJ	_	34	amod	_	_
34	stage	stage	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Reduction	reduction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	tumour	tumour	NN	NN	_	6	compound	_	_
4	necrosis	necrosis	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	1	nmod	_	_
7	expression	expression	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	signalling	signalling	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
12	blood	blood	NN	NN	_	14	compound	_	_
13	mononuclear	mononuclear	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	6	nmod	_	_
15	from	from	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	thalassaemia	thalassaemia	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	sickle	sickle	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	anaemia	anaemia	NN	NN	_	18	conj	_	_
23	upon	upon	IN	IN	_	24	case	_	_
24	treatment	treatment	NN	NN	_	1	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	desferrioxamine	desferrioxamine	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	1	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	rate	rate	NN	NN	_	15	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	progression	progression	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	HIV-1	hiv-1	NN	NN	_	12	compound	_	_
12	disease	disease	NN	NN	_	8	nmod	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	significantly	significantly	RB	RB	_	15	advmod	_	_
15	reduced	reduce	VBN	VBN	_	3	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	thalassaemia	thalassaemia	NN	NN	_	19	compound	_	_
18	major	major	JJ	JJ	_	19	amod	_	_
19	patients	patient	NNS	NNS	_	15	nmod	_	_
20	upon	upon	IN	IN	_	21	case	_	_
21	treatment	treatment	NN	NN	_	15	nmod	_	_
22	with	with	IN	IN	_	24	case	_	_
23	high	high	JJ	JJ	_	24	amod	_	_
24	doses	dose	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	desferrioxamine	desferrioxamine	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	DFX	dfx	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	authors	author	NNS	NNS	_	5	nsubj	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	previously	previously	RB	RB	_	5	advmod	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	in	in	FW	FW	_	9	amod	_	_
8	vitro	vitro	FW	FW	_	7	dep	_	_
9	exposure	exposure	NN	NN	_	15	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	DFX	dfx	NN	NN	_	9	nmod	_	_
15	decreases	decrease	VBZ	VBZ	_	5	ccomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	bioavailability	bioavailability	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	tumour	tumour	NN	NN	_	22	compound	_	_
20	necrosis	necrosis	NN	NN	_	22	compound	_	_
21	factor	factor	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	17	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	which	which	WDT	WDT	_	27	nsubj	_	_
27	has	have	VBZ	VBZ	_	22	acl:relcl	_	_
28	a	a	DT	DT	_	30	det	_	_
29	stimulatory	stimulatory	JJ	JJ	_	30	amod	_	_
30	effect	effect	NN	NN	_	27	dobj	_	_
31	on	on	IN	IN	_	33	case	_	_
32	HIV-1	hiv-1	NN	NN	_	33	compound	_	_
33	replication	replication	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	32	nmod	_	_
4	,	,	,	,	_	32	punct	_	_
5	therefore	therefore	RB	RB	_	32	advmod	_	_
6	,	,	,	,	_	32	punct	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	8	compound	_	_
8	bioavailability	bioavailability	NN	NN	_	32	nsubjpass	_	_
9	from	from	IN	IN	_	11	case	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	isolated	isolate	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	10	10	CD	CD	_	15	nummod	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	thalassaemia	thalassaemia	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	sickle	sickle	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	anaemia	anaemia	NN	NN	_	17	conj	_	_
22	given	give	VBN	VBN	_	15	acl	_	_
23	DFX	dfx	NN	NN	_	22	dobj	_	_
24	as	as	IN	IN	_	25	mark	_	_
25	compared	compare	VBN	VBN	_	8	dep	_	_
26	to	to	TO	TO	_	29	case	_	_
27	10	10	CD	CD	_	29	nummod	_	_
28	untreated	untreated	JJ	JJ	_	29	amod	_	_
29	subjects	subject	NNS	NNS	_	25	nmod	_	_
30	has	have	VBZ	VBZ	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	evaluated	evaluate	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	Evidence	evidence	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	presented	present	VBN	VBN	_	0	root	_	_
4	showing	show	VBG	VBG	_	3	xcomp	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	DFX	dfx	NN	NN	_	7	compound	_	_
7	treatment	treatment	NN	NN	_	8	nsubj	_	_
8	reduces	reduce	VBZ	VBZ	_	4	ccomp	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	compound	_	_
10	bioavailability	bioavailability	NN	NN	_	8	dobj	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	P	p	NN	NN	_	13	dep	_	_
13	&lt;	&lt;	JJR	JJR	_	8	parataxis	_	_
14	0.05	0.05	CD	CD	_	13	nummod	_	_
15	)	)	-RRB-	-RRB-	_	13	punct	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	inhibiting	inhibit	VBG	VBG	_	8	dep	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	steady	steady	JJ	JJ	_	20	amod	_	_
20	state	state	NN	NN	_	17	dobj	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	P	p	NN	NN	_	23	dep	_	_
23	&lt;	&lt;	JJR	JJR	_	17	parataxis	_	_
24	0.05	0.05	CD	CD	_	23	nummod	_	_
25	)	)	-RRB-	-RRB-	_	23	punct	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	enhancing	enhance	VBG	VBG	_	17	conj	_	_
29	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
30	inactivation	inactivation	NN	NN	_	28	dobj	_	_
31	through	through	IN	IN	_	32	case	_	_
32	binding	binding	NN	NN	_	28	nmod	_	_
33	to	to	TO	TO	_	37	case	_	_
34	soluble	soluble	JJ	JJ	_	37	amod	_	_
35	TNF-alpha	tnf-alpha	NN	NN	_	37	compound	_	_
36	receptor	receptor	NN	NN	_	37	compound	_	_
37	type	type	NN	NN	_	32	nmod	_	_
38	II	ii	CD	CD	_	37	nummod	_	_
39	(	(	-LRB-	-LRB-	_	41	punct	_	_
40	P	p	NN	NN	_	41	dep	_	_
41	&lt;	&lt;	JJR	JJR	_	28	parataxis	_	_
42	0.05	0.05	CD	CD	_	41	nummod	_	_
43	)	)	-RRB-	-RRB-	_	41	punct	_	_
44	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	DFX	dfx	NN	NN	_	6	compound	_	_
6	treatment	treatment	NN	NN	_	7	nsubj	_	_
7	limits	limit	VBZ	VBZ	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vivo	vivo	FW	FW	_	9	dep	_	_
11	activation	activation	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	appos	_	_
18	involved	involve	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	23	case	_	_
20	both	both	CC	CC	_	23	cc:preconj	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	26	compound	_	_
26	signalling	signalling	NN	NN	_	23	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	P	p	NN	NN	_	29	dep	_	_
29	&lt;	&lt;	JJR	JJR	_	7	parataxis	_	_
30	0.005	0.005	CD	CD	_	29	nummod	_	_
31	)	)	-RRB-	-RRB-	_	29	punct	_	_
32	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	9	nsubj	_	_
5	bioavailability	bioavailability	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	signalling	signalling	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	9	aux	_	_
9	impaired	impaired	JJ	JJ	_	2	ccomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	9	nmod	_	_
12	upon	upon	IN	IN	_	14	case	_	_
13	DFX	dfx	NN	NN	_	14	compound	_	_
14	treatment	treatment	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	contribute	contribute	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	delayed	delay	VBN	VBN	_	7	amod	_	_
7	progression	progression	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	HIV-1	hiv-1	NN	NN	_	11	compound	_	_
11	infection	infection	NN	NN	_	7	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	4	advmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Copyright	copyright	NN	NN	_	2	dep	_	_
2	1999	1999	CD	CD	_	0	root	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	2	dep	_	_
5	.	.	.	.	_	2	punct	_	_

1	Involvement	involvement	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	adenylate	adenylate	JJ	JJ	_	4	amod	_	_
4	cyclase	cyclase	NN	NN	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	p70(S6)-kinase	p70(s6)-kinase	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	IL-10	il-10	NN	NN	_	10	compound	_	_
10	up-regulation	up-regulation	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	gp41	gp41	NN	NN	_	17	compound	_	_
16	envelope	envelope	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	immunodeficiency	immunodeficiency	NN	NN	_	22	compound	_	_
21	virus	virus	NN	NN	_	22	compound	_	_
22	type	type	NN	NN	_	17	nmod	_	_
23	1	1	CD	CD	_	22	nummod	_	_
24	.	.	.	.	_	1	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	20	mark	_	_
6	recombinant	recombinant	JJ	JJ	_	7	amod	_	_
7	gp41	gp41	NN	NN	_	20	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	aa565-647	aa565-647	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	extracellular	extracellular	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	7	appos	_	_
15	of	of	IN	IN	_	18	case	_	_
16	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
17	transmembrane	transmembrane	JJ	JJ	_	18	amod	_	_
18	glycoprotein	glycoprotein	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	stimulates	stimulate	VBZ	VBZ	_	4	ccomp	_	_
21	interleukin-10	interleukin-10	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	IL-10	il-10	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	production	production	NN	NN	_	20	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	human	human	JJ	JJ	_	28	amod	_	_
28	monocytes	monocyte	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	cascade	cascade	NN	NN	_	10	nsubj	_	_
4	transducing	transduce	VBG	VBG	_	3	acl	_	_
5	this	this	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	yet	yet	RB	RB	_	10	advmod	_	_
10	clear	clear	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	whether	whether	IN	IN	_	12	mark	_	_
8	gp41-induced	gp41-induced	JJ	JJ	_	10	amod	_	_
9	IL-10	il-10	NN	NN	_	10	compound	_	_
10	up-regulation	up-regulation	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	6	ccomp	_	_
13	by	by	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	previously	previously	RB	RB	_	16	advmod	_	_
16	described	describe	VBN	VBN	_	18	amod	_	_
17	synergistic	synergistic	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	12	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	cAMP	camp	NN	NN	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	conj	_	_
23	pathways	pathway	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	gp41	gp41	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	cAMP	camp	NN	NN	_	4	compound	_	_
4	accumulation	accumulation	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	time-	time-	NN	NN	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	concentration-dependent	concentration-dependent	JJ	JJ	_	9	conj	_	_
12	manner	manner	NN	NN	_	2	nmod	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	the	the	DT	DT	_	18	det	_	_
15	adenylate	adenylate	JJ	JJ	_	18	amod	_	_
16	cyclase	cyclase	NN	NN	_	18	compound	_	_
17	inhibitor	inhibitor	NN	NN	_	18	compound	_	_
18	SQ	sq	NN	NN	_	20	nsubj	_	_
19	22536	22536	CD	CD	_	18	nummod	_	_
20	suppressed	suppress	VBD	VBD	_	2	conj	_	_
21	gp41-induced	gp41-induced	JJ	JJ	_	23	amod	_	_
22	IL-10	il-10	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	gp41	gp41	NN	NN	_	5	nsubj	_	_
5	failed	fail	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	stimulate	stimulate	VB	VB	_	5	xcomp	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	17	mark	_	_
12	as	as	RB	RB	_	17	advmod	_	_
13	much	much	JJ	JJ	_	17	dep	_	_
14	as	as	IN	IN	_	17	mark	_	_
15	no	no	DT	DT	_	16	neg	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	nsubj	_	_
17	bound	bind	VBD	VBD	_	7	advcl	_	_
18	to	to	TO	TO	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	main	main	JJ	JJ	_	22	amod	_	_
21	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	22	amod	_	_
22	site	site	NN	NN	_	17	nmod	_	_
23	2	2	CD	CD	_	22	nummod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	IL-10	il-10	NN	NN	_	27	compound	_	_
27	promoter	promoter	NN	NN	_	22	nmod	_	_
28	after	after	IN	IN	_	29	case	_	_
29	addition	addition	NN	NN	_	17	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	gp41	gp41	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	involvement	involvement	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	other	other	JJ	JJ	_	10	amod	_	_
8	signal	signal	NN	NN	_	10	compound	_	_
9	transduction	transduction	NN	NN	_	10	compound	_	_
10	pathways	pathway	NNS	NNS	_	5	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	Specific	specific	JJ	JJ	_	2	amod	_	_
2	inhibitors	inhibitor	NNS	NNS	_	17	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	p70(S6)-kinase	p70(s6)-kinase	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	rapamycin	rapamycin	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	Gi	gi	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	pertussis	pertussis	NN	NN	_	14	compound	_	_
14	toxin	toxin	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	4	punct	_	_
17	prevented	prevent	VBD	VBD	_	0	root	_	_
18	induction	induction	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	IL-10	il-10	NN	NN	_	21	compound	_	_
21	production	production	NN	NN	_	18	nmod	_	_
22	by	by	IN	IN	_	23	case	_	_
23	gp41	gp41	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
26	,	,	,	,	_	17	punct	_	_
27	while	while	IN	IN	_	52	mark	_	_
28	inhibitors	inhibitor	NNS	NNS	_	52	nsubj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	phosphatidylinositol	phosphatidylinositol	NN	NN	_	32	compound	_	_
32	3-kinase	3-kinase	NN	NN	_	28	nmod	_	_
33	(	(	-LRB-	-LRB-	_	35	punct	_	_
34	PI	pi	NN	NN	_	35	compound	_	_
35	3-kinase	3-kinase	NN	NN	_	32	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	wortmannin	wortmannin	NN	NN	_	32	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	and	and	CC	CC	_	32	cc	_	_
41	mitogen-activated	mitogen-activated	JJ	JJ	_	43	amod	_	_
42	protein	protein	NN	NN	_	43	compound	_	_
43	kinase	kinase	NN	NN	_	47	compound	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	MAPK	mapk	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	pathway	pathway	NN	NN	_	32	conj	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	PD	pd	NN	NN	_	47	appos	_	_
50	98059	98059	CD	CD	_	49	nummod	_	_
51	)	)	-RRB-	-RRB-	_	49	punct	_	_
52	did	do	VBD	VBD	_	17	advcl	_	_
53	not	not	RB	RB	_	52	neg	_	_
54	.	.	.	.	_	17	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	HIV-1	hiv-1	NN	NN	_	5	compound	_	_
3	gp41-induced	gp41-induced	JJ	JJ	_	5	amod	_	_
4	IL-10	il-10	NN	NN	_	5	compound	_	_
5	up-regulation	up-regulation	NN	NN	_	10	nsubj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	involve	involve	VB	VB	_	0	root	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
12	,	,	,	,	_	13	punct	_	_
13	MAPK	mapk	NN	NN	_	10	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	or	or	CC	CC	_	13	cc	_	_
16	PI	pi	NN	NN	_	18	compound	_	_
17	3-kinase	3-kinase	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	10	punct	_	_
20	but	but	CC	CC	_	21	cc	_	_
21	rather	rather	RB	RB	_	10	cc	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	operate	operate	VB	VB	_	10	conj	_	_
24	through	through	IN	IN	_	25	case	_	_
25	activation	activation	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	adenylate	adenylate	JJ	JJ	_	28	amod	_	_
28	cyclase	cyclase	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	pertussis-toxin-sensitive	pertussis-toxin-sensitive	JJ	JJ	_	32	amod	_	_
31	Gi/Go	gi/go	NN	NN	_	32	compound	_	_
32	protein	protein	NN	NN	_	28	conj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	effect	effect	VB	VB	_	23	xcomp	_	_
35	p70(S6)-kinase	p70(s6)-kinase	NN	NN	_	36	compound	_	_
36	activation	activation	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	10	punct	_	_

1	Estrone	estrone	NN	NN	_	2	nsubj	_	_
2	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
3	myeloid	myeloid	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	differentiation	differentiation	NN	NN	_	2	dobj	_	_
6	:	:	:	:	_	2	punct	_	_
7	a	a	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	2	dep	_	_
9	for	for	IN	IN	_	12	case	_	_
10	17	17	CD	CD	_	12	nummod	_	_
11	beta-hydroxysteroid	beta-hydroxysteroid	NN	NN	_	12	compound	_	_
12	dehydrogenase	dehydrogenase	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	modulating	modulate	VBG	VBG	_	8	acl	_	_
15	hemopoiesis	hemopoiesis	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Hormones	hormone	NNS	NNS	_	20	nsubj	_	_
2	such	such	JJ	JJ	_	7	case	_	_
3	as	as	IN	IN	_	2	mwe	_	_
4	1	1	CD	CD	_	7	nummod	_	_
5	alpha,25-dihydroxy	alpha,25-dihydroxy	NN	NN	_	7	compound	_	_
6	vitamin	vitamin	NN	NN	_	7	compound	_	_
7	D3	d3	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	D3	d3	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	all-trans	all-trans	JJ	JJ	_	14	amod	_	_
13	retinoic	retinoic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	7	conj	_	_
15	,	,	,	,	_	7	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	9-cis	9-cis	JJ	JJ	_	19	amod	_	_
18	retinoic	retinoic	JJ	JJ	_	19	amod	_	_
19	acid	acid	NN	NN	_	7	conj	_	_
20	stimulate	stimulate	VBP	VBP	_	0	root	_	_
21	differentiation	differentiation	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	myeloid	myeloid	JJ	JJ	_	25	amod	_	_
24	progenitor	progenitor	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	via	via	IN	IN	_	28	case	_	_
27	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
28	interaction	interaction	NN	NN	_	20	nmod	_	_
29	with	with	IN	IN	_	32	case	_	_
30	specific	specific	JJ	JJ	_	32	amod	_	_
31	hormone	hormone	NN	NN	_	32	compound	_	_
32	receptors	receptor	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	20	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	sensitivity	sensitivity	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	cells	cell	NNS	NNS	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	agents	agent	NNS	NNS	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	13	auxpass	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	merely	merely	RB	RB	_	13	advmod	_	_
13	governed	govern	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
19	receptors	receptor	NNS	NNS	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	availability	availability	NN	NN	_	16	conj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	ligand	ligand	NN	NN	_	22	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	bind	bind	VB	VB	_	24	acl	_	_
27	them	they	PRP	PRP	_	26	dobj	_	_
28	.	.	.	.	_	13	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	6	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	group	group	NN	NN	_	2	nmod	_	_
6	suggested	suggest	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	actions	action	NNS	NNS	_	18	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	D3	d3	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	retinoids	retinoid	NNS	NNS	_	11	conj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	myelopoiesis	myelopoiesis	NN	NN	_	9	nmod	_	_
16	also	also	RB	RB	_	18	advmod	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	influenced	influence	VBN	VBN	_	6	ccomp	_	_
19	by	by	IN	IN	_	21	case	_	_
20	endogenous	endogenous	JJ	JJ	_	21	amod	_	_
21	mechanisms	mechanism	NNS	NNS	_	18	nmod	_	_
22	involving	involve	VBG	VBG	_	21	acl	_	_
23	other	other	JJ	JJ	_	25	amod	_	_
24	steroid	steroid	NN	NN	_	25	compound	_	_
25	hormones	hormone	NNS	NNS	_	22	dobj	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	examined	examine	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	influence	influence	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	local	local	JJ	JJ	_	11	amod	_	_
10	estrogen	estrogen	NN	NN	_	11	compound	_	_
11	metabolism	metabolism	NN	NN	_	7	nmod	_	_
12	on	on	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	differentiation	differentiation	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	HL60	hl60	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	normal	normal	JJ	JJ	_	23	amod	_	_
20	primitive	primitive	JJ	JJ	_	23	amod	_	_
21	myeloid	myeloid	JJ	JJ	_	23	amod	_	_
22	progenitor	progenitor	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	17	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Quantitative	quantitative	JJ	JJ	_	7	amod	_	_
2	thin-layer	thin-layer	JJ	JJ	_	3	amod	_	_
3	chromatography	chromatography	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TLC	tlc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	analyses	analysis	NNS	NNS	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	HL60	hl60	NN	NN	_	13	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	normal	normal	JJ	JJ	_	10	conj	_	_
13	cells	cell	NNS	NNS	_	15	nsubj	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	able	able	JJ	JJ	_	8	ccomp	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	generate	generate	VB	VB	_	15	xcomp	_	_
18	estrone	estrone	NN	NN	_	17	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	E1	e1	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	from	from	IN	IN	_	23	case	_	_
23	estradiol	estradiol	NN	NN	_	17	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	E2	e2	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	8	punct	_	_

1	Neither	neither	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	population	population	NN	NN	_	4	nsubj	_	_
4	generated	generate	VBD	VBD	_	0	root	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	amounts	amount	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	E2	e2	NN	NN	_	6	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	E1	e1	NN	NN	_	4	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Reverse	reverse	NN	NN	_	5	compound	_	_
2	transcriptase	transcriptase	NN	NN	_	5	compound	_	_
3	polymerase	polymerase	NN	NN	_	5	compound	_	_
4	chain	chain	NN	NN	_	5	compound	_	_
5	reaction	reaction	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Northern	northern	NN	NN	_	8	compound	_	_
8	analyses	analysis	NNS	NNS	_	5	conj	_	_
9	confirmed	confirm	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	normal	normal	JJ	JJ	_	16	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	leukemic	leukemic	JJ	JJ	_	15	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	progenitor	progenitor	NN	NN	_	11	conj	_	_
16	cells	cell	NNS	NNS	_	17	nsubj	_	_
17	expressed	express	VBD	VBD	_	9	ccomp	_	_
18	mRNA	mrna	NN	NN	_	17	dobj	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	type	type	NN	NN	_	18	nmod	_	_
22	I	i	CD	CD	_	21	nummod	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	IV	iv	CD	CD	_	25	nummod	_	_
25	isoforms	isoform	NNS	NNS	_	21	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	17	17	CD	CD	_	29	nummod	_	_
28	beta-hydroxysteroid	beta-hydroxysteroid	NN	NN	_	29	compound	_	_
29	dehydrogenase	dehydrogenase	NN	NN	_	21	nmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	Conversion	conversion	NN	NN	_	7	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	E2	e2	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	5	case	_	_
5	E1	e1	NN	NN	_	1	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	upregulated	upregulate	VBN	VBN	_	0	root	_	_
8	within	within	IN	IN	_	10	case	_	_
9	24	24	CD	CD	_	10	nummod	_	_
10	hours	hour	NNS	NNS	_	7	nmod	_	_
11	when	when	WRB	WRB	_	15	advmod	_	_
12	HL60	hl60	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	15	nsubjpass	_	_
14	were	be	VBD	VBD	_	15	auxpass	_	_
15	treated	treat	VBN	VBN	_	7	advcl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	either	either	CC	CC	_	20	cc:preconj	_	_
18	all-trans	all-trans	JJ	JJ	_	20	amod	_	_
19	retinoic	retinoic	JJ	JJ	_	20	amod	_	_
20	acid	acid	NN	NN	_	15	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	D3	d3	NN	NN	_	20	conj	_	_
23	at	at	IN	IN	_	24	case	_	_
24	doses	dose	NNS	NNS	_	15	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	induce	induce	VBP	VBP	_	24	acl:relcl	_	_
27	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
28	differentiation	differentiation	NN	NN	_	26	dobj	_	_
29	toward	toward	IN	IN	_	30	case	_	_
30	neutrophils	neutrophil	NNS	NNS	_	28	nmod	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	monocytes	monocyte	NNS	NNS	_	30	conj	_	_
33	,	,	,	,	_	26	punct	_	_
34	respectively	respectively	RB	RB	_	26	advmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	Similarly	similarly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	D3-induced	d3-induced	JJ	JJ	_	5	amod	_	_
4	monocyte	monocyte	NN	NN	_	5	compound	_	_
5	differentiation	differentiation	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	normal	normal	JJ	JJ	_	10	amod	_	_
8	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
9	progenitor	progenitor	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	increased	increase	VBN	VBN	_	15	amod	_	_
15	capacity	capacity	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	generate	generate	VB	VB	_	15	acl	_	_
18	E1	e1	NN	NN	_	17	dobj	_	_
19	from	from	IN	IN	_	20	case	_	_
20	E2	e2	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	When	when	WRB	WRB	_	10	advmod	_	_
2	HL60	hl60	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	normal	normal	JJ	JJ	_	8	amod	_	_
6	myeloid	myeloid	JJ	JJ	_	8	amod	_	_
7	progenitor	progenitor	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	exposed	expose	VBN	VBN	_	15	advcl	_	_
11	to	to	TO	TO	_	13	case	_	_
12	exogenous	exogenous	JJ	JJ	_	13	amod	_	_
13	E1	e1	NN	NN	_	10	nmod	_	_
14	they	they	PRP	PRP	_	15	nsubj	_	_
15	became	become	VBD	VBD	_	0	root	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	sensitive	sensitive	JJ	JJ	_	15	xcomp	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	differentiation-inducing	differentiation-inducing	JJ	JJ	_	21	amod	_	_
21	effects	effect	NNS	NNS	_	17	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	D3	d3	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Data	datum	NNS	NNS	_	3	nsubj	_	_
2	presented	present	VBN	VBN	_	1	acl	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	further	further	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	local	local	JJ	JJ	_	9	amod	_	_
9	modulation	modulation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	myelopoiesis	myelopoiesis	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	intracrine	intracrine	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	particular	particular	JJ	JJ	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	local	local	JJ	JJ	_	9	amod	_	_
9	metabolism	metabolism	NN	NN	_	20	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	steroids	steroid	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	normal	normal	JJ	JJ	_	9	acl	_	_
14	as	as	RB	RB	_	13	cc	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	as	as	IN	IN	_	14	mwe	_	_
17	leukemic	leukemic	JJ	JJ	_	18	amod	_	_
18	myeloid	myeloid	JJ	JJ	_	13	conj	_	_
19	cells	cell	NNS	NNS	_	13	dep	_	_
20	influences	influence	VBZ	VBZ	_	6	ccomp	_	_
21	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
22	responsiveness	responsiveness	NN	NN	_	20	dobj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	D3	d3	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	retinoids	retinoid	NNS	NNS	_	24	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	relationship	relationship	NN	NN	_	0	root	_	_
3	between	between	IN	IN	_	4	case	_	_
4	Ca2+-ATPase	ca2+-atpase	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	freely	freely	RB	RB	_	7	advmod	_	_
7	exchangeable	exchangeable	JJ	JJ	_	8	amod	_	_
8	Ca2+	ca2+	NN	NN	_	4	conj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	dense	dense	JJ	JJ	_	12	amod	_	_
12	tubules	tubule	NNS	NNS	_	8	nmod	_	_
13	:	:	:	:	_	2	punct	_	_
14	a	a	DT	DT	_	15	det	_	_
15	study	study	NN	NN	_	2	dep	_	_
16	in	in	IN	IN	_	17	case	_	_
17	platelets	platelet	NNS	NNS	_	15	nmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	women	woman	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	main	main	JJ	JJ	_	3	amod	_	_
3	aims	aim	NNS	NNS	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	this	this	DT	DT	_	6	det	_	_
6	work	work	NN	NN	_	3	nmod	_	_
7	were	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	examine	examine	VB	VB	_	7	xcomp	_	_
10	in	in	IN	IN	_	11	case	_	_
11	women	woman	NNS	NNS	_	9	nmod	_	_
12	:	:	:	:	_	9	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	relationship	relationship	NN	NN	_	9	dobj	_	_
15	between	between	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	freely	freely	RB	RB	_	18	advmod	_	_
18	exchangeable	exchangeable	JJ	JJ	_	19	amod	_	_
19	Ca2+	ca2+	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	FECa2+	feca2+	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	dense	dense	JJ	JJ	_	26	amod	_	_
26	tubules	tubule	NNS	NNS	_	19	nmod	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	the	the	DT	DT	_	29	det	_	_
29	activity	activity	NN	NN	_	19	conj	_	_
30	of	of	IN	IN	_	43	case	_	_
31	the	the	DT	DT	_	43	det	_	_
32	sarco	sarco	NN	NN	_	43	compound	_	_
33	(	(	-LRB-	-LRB-	_	43	punct	_	_
34	endo	endo	NN	NN	_	43	compound	_	_
35	)	)	-RRB-	-RRB-	_	43	punct	_	_
36	plasmic	plasmic	JJ	JJ	_	43	amod	_	_
37	reticulum	reticulum	NN	NN	_	43	compound	_	_
38	(	(	-LRB-	-LRB-	_	43	punct	_	_
39	SER	ser	NN	NN	_	43	compound	_	_
40	)	)	-RRB-	-RRB-	_	43	punct	_	_
41	Ca2+-ATPase	ca2+-atpase	NN	NN	_	43	compound	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	SERCA	serca	NN	NN	_	29	nmod	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	in	in	IN	IN	_	46	case	_	_
46	platelets	platelet	NNS	NNS	_	29	nmod	_	_
47	,	,	,	,	_	14	punct	_	_
48	and	and	CC	CC	_	14	cc	_	_
49	the	the	DT	DT	_	50	det	_	_
50	relationship	relationship	NN	NN	_	14	conj	_	_
51	of	of	IN	IN	_	53	case	_	_
52	these	these	DT	DT	_	53	det	_	_
53	parameters	parameter	NNS	NNS	_	50	nmod	_	_
54	with	with	IN	IN	_	56	case	_	_
55	blood	blood	NN	NN	_	56	compound	_	_
56	pressure	pressure	NN	NN	_	50	nmod	_	_
57	and	and	CC	CC	_	56	cc	_	_
58	serum	serum	NN	NN	_	59	compound	_	_
59	lipoproteins	lipoprotein	NNS	NNS	_	56	conj	_	_
60	.	.	.	.	_	7	punct	_	_

1	Platelets	platelet	NNS	NNS	_	13	nsubjpass	_	_
2	from	from	IN	IN	_	4	case	_	_
3	14	14	CD	CD	_	4	nummod	_	_
4	white	white	JJ	JJ	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	13	13	CD	CD	_	7	nummod	_	_
7	black	black	JJ	JJ	_	4	conj	_	_
8	women	woman	NNS	NNS	_	4	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	good	good	JJ	JJ	_	11	amod	_	_
11	health	health	NN	NN	_	4	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	studied	study	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	FECa2+	feca2+	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	measured	measure	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	ionomycin-evoked	ionomycin-evoked	JJ	JJ	_	9	amod	_	_
8	Ca2+	ca2+	NN	NN	_	9	compound	_	_
9	release	release	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	in	in	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	dep	_	_
13	presence	presence	NN	NN	_	15	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	thapsigargin	thapsigargin	NN	NN	_	9	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	Ca2+-free	ca2+-free	JJ	JJ	_	19	amod	_	_
19	medium	medium	NN	NN	_	9	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	SERCA	serca	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	measured	measure	VBN	VBN	_	0	root	_	_
5	as	as	IN	IN	_	17	case	_	_
6	the	the	DT	DT	_	17	det	_	_
7	thapsigargin	thapsigargin	NN	NN	_	8	nmod:npmod	_	_
8	sensitive	sensitive	JJ	JJ	_	17	amod	_	_
9	,	,	,	,	_	8	punct	_	_
10	Ca2+	ca2+	NN	NN	_	11	nmod:npmod	_	_
11	dependent	dependent	JJ	JJ	_	8	conj	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	ouabain	ouabain	NN	NN	_	14	nmod:npmod	_	_
14	resistant	resistant	JJ	JJ	_	8	conj	_	_
15	,	,	,	,	_	8	punct	_	_
16	ATP	atp	NN	NN	_	17	compound	_	_
17	hydrolyses	hydrolys	NNS	NNS	_	4	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	platelet	platelet	NN	NN	_	20	compound	_	_
20	membranes	membrane	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Relative	relative	JJ	JJ	_	2	amod	_	_
2	expressions	expression	NNS	NNS	_	20	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SERCA	serca	NN	NN	_	2	nmod	_	_
5	2	2	CD	CD	_	4	nummod	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	3	3	CD	CD	_	8	nummod	_	_
8	isoforms	isoform	NNS	NNS	_	4	conj	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	Ras-related	ras-related	JJ	JJ	_	13	amod	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Rap	rap	NN	NN	_	4	conj	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	1	1	CD	CD	_	13	nummod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	platelet	platelet	NN	NN	_	18	compound	_	_
18	membranes	membrane	NNS	NNS	_	2	nmod	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	determined	determine	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	Western	western	NN	NN	_	23	compound	_	_
23	immunoblots	immunoblot	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	Highly	highly	RB	RB	_	2	advmod	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	correlations	correlation	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	FECa2+	feca2+	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	dense	dense	JJ	JJ	_	11	amod	_	_
11	tubules	tubule	NNS	NNS	_	7	nmod	_	_
12	with	with	IN	IN	_	19	case	_	_
13	:	:	:	:	_	19	punct	_	_
14	1	1	LS	LS	_	19	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	the	the	DT	DT	_	19	det	_	_
17	maximal	maximal	JJ	JJ	_	19	amod	_	_
18	reaction	reaction	NN	NN	_	19	compound	_	_
19	velocity	velocity	NN	NN	_	11	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	Vmax	vmax	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	SERCA	serca	NN	NN	_	19	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	r	r	NN	NN	_	28	nsubj	_	_
28	=	=	JJ	JJ	_	19	dep	_	_
29	0.592	0.592	CD	CD	_	28	dobj	_	_
30	,	,	,	,	_	28	punct	_	_
31	P	p	NN	NN	_	32	nsubj	_	_
32	=	=	JJ	JJ	_	28	parataxis	_	_
33	.0014	.0014	CD	CD	_	32	dobj	_	_
34	)	)	-RRB-	-RRB-	_	28	punct	_	_
35	,	,	,	,	_	19	punct	_	_
36	and	and	CC	CC	_	19	cc	_	_
37	2	2	LS	LS	_	39	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	Rapl	rapl	NN	NN	_	19	conj	_	_
40	(	(	-LRB-	-LRB-	_	42	punct	_	_
41	r	r	NN	NN	_	42	nsubj	_	_
42	=	=	JJ	JJ	_	39	dep	_	_
43	0.551	0.551	CD	CD	_	42	dobj	_	_
44	,	,	,	,	_	42	punct	_	_
45	P	p	NN	NN	_	46	nsubj	_	_
46	=	=	JJ	JJ	_	42	parataxis	_	_
47	.0035	.0035	CD	CD	_	46	dobj	_	_
48	)	)	-RRB-	-RRB-	_	42	punct	_	_
49	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	correlations	correlation	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	between	between	IN	IN	_	9	case	_	_
9	FECa2+	feca2+	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	dense	dense	JJ	JJ	_	13	amod	_	_
13	tubules	tubule	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	age	age	NN	NN	_	9	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlations	correlation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	variables	variable	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	pressure	pressure	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	serum	serum	NN	NN	_	13	compound	_	_
13	lipoproteins	lipoprotein	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	FECa2+	feca2+	NN	NN	_	13	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	the	the	DT	DT	_	7	det	_	_
7	Vmax	vmax	NN	NN	_	4	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	SERCA	serca	NN	NN	_	7	nmod	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	reliable	reliable	JJ	JJ	_	13	amod	_	_
13	indicators	indicator	NNS	NNS	_	2	ccomp	_	_
14	of	of	IN	IN	_	16	case	_	_
15	Ca2+	ca2+	NN	NN	_	16	compound	_	_
16	load	load	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	platelets	platelet	NNS	NNS	_	16	nmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	women	woman	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	women	woman	NNS	NNS	_	17	nmod	_	_
5	,	,	,	,	_	17	punct	_	_
6	unlike	unlike	IN	IN	_	8	case	_	_
7	previous	previous	JJ	JJ	_	8	amod	_	_
8	observations	observation	NNS	NNS	_	17	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	men	man	NNS	NNS	_	8	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	these	these	DT	DT	_	14	det	_	_
13	platelet	platelet	NN	NN	_	14	compound	_	_
14	parameters	parameter	NNS	NNS	_	17	nsubjpass	_	_
15	are	be	VBP	VBP	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	correlated	correlate	VBN	VBN	_	0	root	_	_
18	with	with	IN	IN	_	20	case	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	pressure	pressure	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	serum	serum	NN	NN	_	23	compound	_	_
23	lipoproteins	lipoprotein	NNS	NNS	_	20	conj	_	_
24	.	.	.	.	_	17	punct	_	_

1	Nonimmunoglobulin	nonimmunoglobulin	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	hypermutation	hypermutation	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	germinal	germinal	JJ	JJ	_	8	amod	_	_
6	center	center	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	Somatic	somatic	JJ	JJ	_	2	amod	_	_
2	hypermutation	hypermutation	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	the	the	DT	DT	_	7	det	_	_
5	most	most	RBS	RBS	_	6	advmod	_	_
6	critical	critical	JJ	JJ	_	7	amod	_	_
7	mechanism	mechanism	NN	NN	_	0	root	_	_
8	underlying	underlie	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	diversification	diversification	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Ig	ig	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	mutation	mutation	NN	NN	_	3	nsubj	_	_
3	occurs	occur	VBZ	VBZ	_	15	advcl	_	_
4	specifically	specifically	RB	RB	_	7	advmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	B	b	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	during	during	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	germinal	germinal	JJ	JJ	_	12	amod	_	_
11	center	center	NN	NN	_	12	compound	_	_
12	reaction	reaction	NN	NN	_	3	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	it	it	PRP	PRP	_	15	nsubj	_	_
15	remains	remain	VBZ	VBZ	_	0	root	_	_
16	a	a	DT	DT	_	17	det	_	_
17	matter	matter	NN	NN	_	15	xcomp	_	_
18	of	of	IN	IN	_	19	case	_	_
19	debate	debate	NN	NN	_	17	nmod	_	_
20	whether	whether	IN	IN	_	25	mark	_	_
21	the	the	DT	DT	_	23	det	_	_
22	mutation	mutation	NN	NN	_	23	compound	_	_
23	machinery	machinery	NN	NN	_	25	nsubj	_	_
24	also	also	RB	RB	_	25	advmod	_	_
25	targets	target	VBZ	VBZ	_	15	ccomp	_	_
26	non-Ig	non-ig	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	25	dobj	_	_
28	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	mutations	mutation	NNS	NNS	_	3	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	5'	5'	JJ	JJ	_	9	amod	_	_
8	noncoding	noncoding	JJ	JJ	_	9	amod	_	_
9	region	region	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	Bcl6	bcl6	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	different	different	JJ	JJ	_	16	amod	_	_
16	subtypes	subtype	NNS	NNS	_	4	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	lymphomas	lymphoma	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	frequent	frequent	JJ	JJ	_	4	amod	_	_
4	hypermutation	hypermutation	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	follicular	follicular	JJ	JJ	_	7	amod	_	_
7	lymphoma	lymphoma	NN	NN	_	2	nmod	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	25	25	CD	CD	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	59	59	CD	CD	_	9	nmod	_	_
12	=	=	JJ	JJ	_	7	dep	_	_
13	42	42	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	12	dobj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	(	(	-LRB-	-LRB-	_	20	punct	_	_
17	germinal	germinal	JJ	JJ	_	20	amod	_	_
18	center	center	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	origin	origin	NN	NN	_	7	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	and	and	CC	CC	_	7	cc	_	_
23	mucosa-associated	mucosa-associated	JJ	JJ	_	25	amod	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	tissue	tissue	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	MALT	malt	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	lymphoma	lymphoma	NN	NN	_	7	conj	_	_
30	(	(	-LRB-	-LRB-	_	34	punct	_	_
31	19	19	CD	CD	_	34	nsubj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	45	45	CD	CD	_	31	nmod	_	_
34	=	=	JJ	JJ	_	29	dep	_	_
35	42	42	CD	CD	_	36	nummod	_	_
36	%	%	NN	NN	_	34	dobj	_	_
37	)	)	-RRB-	-RRB-	_	34	punct	_	_
38	(	(	-LRB-	-LRB-	_	40	punct	_	_
39	postgerminal	postgerminal	JJ	JJ	_	40	amod	_	_
40	center	center	NN	NN	_	29	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	7	punct	_	_
43	but	but	CC	CC	_	7	cc	_	_
44	only	only	RB	RB	_	45	advmod	_	_
45	occasionally	occasionally	RB	RB	_	49	advmod	_	_
46	in	in	IN	IN	_	49	case	_	_
47	mantle	mantle	NN	NN	_	49	compound	_	_
48	cell	cell	NN	NN	_	49	compound	_	_
49	lymphoma	lymphoma	NN	NN	_	7	conj	_	_
50	(	(	-LRB-	-LRB-	_	54	punct	_	_
51	1	1	CD	CD	_	54	nsubj	_	_
52	of	of	IN	IN	_	53	case	_	_
53	21	21	CD	CD	_	51	nmod	_	_
54	=	=	JJ	JJ	_	49	dep	_	_
55	4.8	4.8	CD	CD	_	56	nummod	_	_
56	%	%	NN	NN	_	54	dobj	_	_
57	)	)	-RRB-	-RRB-	_	54	punct	_	_
58	(	(	-LRB-	-LRB-	_	60	punct	_	_
59	pregerminal	pregerminal	JJ	JJ	_	60	amod	_	_
60	center	center	NN	NN	_	49	appos	_	_
61	)	)	-RRB-	-RRB-	_	60	punct	_	_
62	.	.	.	.	_	2	punct	_	_

1	Most	most	JJS	JJS	_	2	amod	_	_
2	mutations	mutation	NNS	NNS	_	6	nsubj	_	_
3	were	be	VBD	VBD	_	6	cop	_	_
4	outside	outside	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	motifs	motif	NNS	NNS	_	0	root	_	_
7	potentially	potentially	RB	RB	_	8	advmod	_	_
8	important	important	JJ	JJ	_	6	amod	_	_
9	for	for	IN	IN	_	10	case	_	_
10	transcription	transcription	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
13	they	they	PRP	PRP	_	16	nsubj	_	_
14	were	be	VBD	VBD	_	16	cop	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	important	important	JJ	JJ	_	12	ccomp	_	_
17	in	in	IN	IN	_	18	case	_	_
18	lymphomagenesis	lymphomagenesis	NN	NN	_	16	nmod	_	_
19	but	but	CC	CC	_	16	cc	_	_
20	may	may	MD	MD	_	26	aux	_	_
21	,	,	,	,	_	26	punct	_	_
22	like	like	IN	IN	_	24	case	_	_
23	Ig	ig	NN	NN	_	24	compound	_	_
24	mutation	mutation	NN	NN	_	26	nmod	_	_
25	,	,	,	,	_	26	punct	_	_
26	represent	represent	VB	VB	_	16	conj	_	_
27	an	a	DT	DT	_	29	det	_	_
28	inherent	inherent	JJ	JJ	_	29	amod	_	_
29	feature	feature	NN	NN	_	26	dobj	_	_
30	of	of	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	lymphoma	lymphoma	NN	NN	_	34	compound	_	_
33	precursor	precursor	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	29	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	their	they	PRP$	PRP$	_	8	nmod:poss	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	counterparts	counterpart	NNS	NNS	_	4	dobj	_	_
9	microdissected	microdissect	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	reactive	reactive	JJ	JJ	_	13	amod	_	_
13	tonsil	tonsil	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Bcl6	bcl6	NN	NN	_	2	compound	_	_
2	mutation	mutation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	13	case	_	_
6	13	13	CD	CD	_	8	compound	_	_
7	of	of	IN	IN	_	8	advmod	_	_
8	24	24	CD	CD	_	13	nummod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	54	54	CD	CD	_	11	nummod	_	_
11	%	%	NN	NN	_	13	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	clones	clone	NNS	NNS	_	4	nmod	_	_
14	from	from	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	germinal	germinal	JJ	JJ	_	17	amod	_	_
17	centre	centre	NN	NN	_	13	nmod	_	_
18	but	but	CC	CC	_	13	cc	_	_
19	only	only	RB	RB	_	28	advmod	_	_
20	in	in	IN	IN	_	28	case	_	_
21	1	1	CD	CD	_	23	compound	_	_
22	of	of	IN	IN	_	23	advmod	_	_
23	24	24	CD	CD	_	28	nummod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	4	4	CD	CD	_	26	nummod	_	_
26	%	%	NN	NN	_	28	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	clones	clone	NNS	NNS	_	13	conj	_	_
29	from	from	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	naive	naive	JJ	JJ	_	33	amod	_	_
32	B	b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	mantle	mantle	NN	NN	_	37	compound	_	_
37	zone	zone	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	frequency	frequency	NN	NN	_	12	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	distribution	distribution	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	nature	nature	NN	NN	_	2	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	mutations	mutation	NNS	NNS	_	2	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	similar	similar	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	those	those	DT	DT	_	12	nmod	_	_
15	resulting	result	VBG	VBG	_	14	acl	_	_
16	from	from	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	Ig	ig	NN	NN	_	20	compound	_	_
19	hypermutation	hypermutation	NN	NN	_	20	compound	_	_
20	process	process	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	unequivocal	unequivocal	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	non-Ig	non-ig	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	hypermutation	hypermutation	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	germinal	germinal	JJ	JJ	_	14	amod	_	_
12	center	center	NN	NN	_	14	compound	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	3	cc	_	_
16	provide	provide	VBP	VBP	_	3	conj	_	_
17	fresh	fresh	JJ	JJ	_	18	amod	_	_
18	insights	insight	NNS	NNS	_	16	dobj	_	_
19	into	into	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	process	process	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	hypermutation	hypermutation	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	lymphomagenesis	lymphomagenesis	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	3	punct	_	_

1	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	2	compound	_	_
2	D3	d3	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	differentiation	differentiation	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	13	case	_	_
6	a	a	DT	DT	_	13	det	_	_
7	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
8	acid-resistant	acid-resistant	JJ	JJ	_	13	amod	_	_
9	acute	acute	JJ	JJ	_	13	amod	_	_
10	promyelocytic	promyelocytic	JJ	JJ	_	13	amod	_	_
11	leukemia	leukemia	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	4	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	UF-1	uf-1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	associated	associate	VBN	VBN	_	13	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	expression	expression	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	p27(KIP1)	p27(kip1)	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	resistance	resistance	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	serious	serious	JJ	JJ	_	10	amod	_	_
10	problem	problem	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	promyelocytic	promyelocytic	JJ	JJ	_	16	amod	_	_
16	leukemia	leukemia	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	APL	apl	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	who	who	WP	WP	_	22	nsubj	_	_
21	are	be	VBP	VBP	_	22	aux	_	_
22	receiving	receive	VBG	VBG	_	12	acl:relcl	_	_
23	all-trans	all-trans	JJ	JJ	_	24	amod	_	_
24	RA	ra	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	16	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	strategies	strategy	NNS	NNS	_	4	conj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	overcome	overcome	VB	VB	_	4	acl	_	_
9	RA	ra	NN	NN	_	10	compound	_	_
10	resistance	resistance	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	13	case	_	_
12	APL	apl	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	are	be	VBP	VBP	_	16	cop	_	_
15	still	still	RB	RB	_	16	advmod	_	_
16	unclear	unclear	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biologic	biologic	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	RA	ra	NN	NN	_	3	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	families	family	NNS	NNS	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	factors	factor	NNS	NNS	_	11	nmod	_	_
15	:	:	:	:	_	11	punct	_	_
16	RA	ra	NN	NN	_	17	compound	_	_
17	receptors	receptor	NNS	NNS	_	11	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	RARs	rar	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	retinoid	retinoid	NN	NN	_	24	compound	_	_
23	X	x	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	17	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	RXRs	rxr	NNS	NNS	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	7	punct	_	_

1	RXRs	rxr	NNS	NNS	_	2	nsubj	_	_
2	heterodimerize	heterodimerize	VBP	VBP	_	0	root	_	_
3	with	with	IN	IN	_	9	case	_	_
4	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	9	compound	_	_
5	D3	d3	NN	NN	_	9	compound	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	9	punct	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	9	compound	_	_
8	-RSB-	-rsb-	-RRB-	-RRB-	_	9	punct	_	_
9	receptor	receptor	NN	NN	_	2	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	VDR	vdr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	2	punct	_	_
14	enabling	enable	VBG	VBG	_	2	xcomp	_	_
15	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
16	efficient	efficient	JJ	JJ	_	18	amod	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	14	dobj	_	_
19	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	8	det	_	_
2	cyclin-dependent	cyclin-dependent	JJ	JJ	_	8	amod	_	_
3	kinase	kinase	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	cdk	cdk	NN	NN	_	8	compound	_	_
6	)	)	-RRB-	-RRB-	_	8	punct	_	_
7	inhibitor	inhibitor	NN	NN	_	8	compound	_	_
8	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	9	nsubj	_	_
9	has	have	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	vitamin	vitamin	NN	NN	_	13	compound	_	_
12	D3-responsive	d3-responsive	JJ	JJ	_	13	amod	_	_
13	element	element	NN	NN	_	9	dobj	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	VDRE	vdre	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
19	promoter	promoter	NN	NN	_	9	nmod	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	23	nsubj	_	_
23	enhances	enhance	VBZ	VBZ	_	9	conj	_	_
24	the	the	DT	DT	_	25	det	_	_
25	expression	expression	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	induces	induce	VBZ	VBZ	_	23	conj	_	_
30	differentiation	differentiation	NN	NN	_	29	dobj	_	_
31	of	of	IN	IN	_	36	case	_	_
32	selected	select	VBN	VBN	_	36	amod	_	_
33	myeloid	myeloid	JJ	JJ	_	36	amod	_	_
34	leukemic	leukemic	JJ	JJ	_	36	amod	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	30	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	established	establish	VBN	VBN	_	0	root	_	_
5	a	a	DT	DT	_	9	det	_	_
6	novel	novel	JJ	JJ	_	9	amod	_	_
7	APL	apl	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	4	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	UF-1	uf-1	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	with	with	IN	IN	_	14	case	_	_
14	features	feature	NNS	NNS	_	9	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	RA	ra	NN	NN	_	17	compound	_	_
17	resistance	resistance	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	induce	induce	VB	VB	_	0	root	_	_
4	growth	growth	NN	NN	_	5	compound	_	_
5	inhibition	inhibition	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	G1	g1	NN	NN	_	8	compound	_	_
8	arrest	arrest	NN	NN	_	5	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	UF-1	uf-1	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	resulting	result	VBG	VBG	_	5	acl	_	_
14	in	in	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	toward	toward	IN	IN	_	20	case	_	_
20	granulocytes	granulocyte	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	1,25(OH)2D3-induced	1,25(oh)2d3-induced	JJ	JJ	_	4	amod	_	_
3	G1	g1	NN	NN	_	4	compound	_	_
4	arrest	arrest	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	enhanced	enhance	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	all-trans	all-trans	JJ	JJ	_	9	amod	_	_
9	RA	ra	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Also	also	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	15	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	8	punct	_	_
5	10(-10)	10(-10)	CD	CD	_	7	compound	_	_
6	to	to	TO	TO	_	7	dep	_	_
7	10(-7)	10(-7)	CD	CD	_	8	nummod	_	_
8	mol/L	mol/l	NN	NN	_	3	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	in	in	IN	IN	_	11	case	_	_
11	combination	combination	NN	NN	_	3	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	RA	ra	NN	NN	_	11	nmod	_	_
14	markedly	markedly	RB	RB	_	15	advmod	_	_
15	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	proliferation	proliferation	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	23	case	_	_
19	a	a	DT	DT	_	23	det	_	_
20	dose-	dose-	NN	NN	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	time-dependent	time-dependent	JJ	JJ	_	20	conj	_	_
23	manner	manner	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Associated	associate	VBN	VBN	_	15	advcl	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	15	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	levels	level	NNS	NNS	_	15	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p27(KIP1)	p27(kip1)	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	conj	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	protein	protein	NN	NN	_	9	conj	_	_
15	increased	increase	VBD	VBD	_	0	root	_	_
16	in	in	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	15	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	12	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p27(KIP1)	p27(kip1)	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	6	conj	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	protein	protein	NN	NN	_	6	conj	_	_
12	increased	increase	VBD	VBD	_	4	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	these	these	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	Northern	northern	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	p27(KIP1)	p27(kip1)	NN	NN	_	6	conj	_	_
9	transcripts	transcript	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	4	ccomp	_	_
12	after	after	IN	IN	_	16	case	_	_
13	6	6	CD	CD	_	14	nummod	_	_
14	hours	hour	NNS	NNS	_	16	nmod:poss	_	_
15	'	'	POS	POS	_	14	case	_	_
16	exposure	exposure	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	then	then	RB	RB	_	21	advmod	_	_
21	decreased	decrease	VBD	VBD	_	11	conj	_	_
22	to	to	TO	TO	_	24	case	_	_
23	basal	basal	JJ	JJ	_	24	amod	_	_
24	levels	level	NNS	NNS	_	21	nmod	_	_
25	over	over	IN	IN	_	27	case	_	_
26	48	48	CD	CD	_	27	nummod	_	_
27	hours	hour	NNS	NNS	_	21	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	8	compound	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	levels	level	NNS	NNS	_	9	nsubj	_	_
9	increased	increase	VBD	VBD	_	4	ccomp	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	became	become	VBD	VBD	_	9	conj	_	_
12	detectable	detectable	JJ	JJ	_	11	xcomp	_	_
13	after	after	IN	IN	_	15	case	_	_
14	12	12	CD	CD	_	15	nummod	_	_
15	hours	hour	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	18	compound	_	_
18	treatment	treatment	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	9	cc	_	_
20	induction	induction	NN	NN	_	27	nsubj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	p27(KIP1)	p27(kip1)	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	20	nmod	_	_
24	was	be	VBD	VBD	_	27	cop	_	_
25	much	much	RB	RB	_	26	advmod	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	gradual	gradual	JJ	JJ	_	9	conj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	sustained	sustained	JJ	JJ	_	27	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	UF-1	uf-1	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Interestingly	interestingly	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	combination	combination	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	RA	ra	NN	NN	_	6	conj	_	_
9	markedly	markedly	RB	RB	_	10	advmod	_	_
10	enhanced	enhance	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	levels	level	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	p27(KIP1)	p27(kip1)	NN	NN	_	12	nmod	_	_
15	transcript	transcript	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	protein	protein	NN	NN	_	15	conj	_	_
18	as	as	IN	IN	_	19	mark	_	_
19	compared	compare	VBN	VBN	_	10	advcl	_	_
20	with	with	IN	IN	_	21	case	_	_
21	levels	level	NNS	NNS	_	19	nmod	_	_
22	induced	induce	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	22	nmod	_	_
25	alone	alone	RB	RB	_	24	advmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	exogenous	exogenous	JJ	JJ	_	6	amod	_	_
5	p27(KIP1)	p27(kip1)	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	enhance	enhance	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	level	level	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	CD11b	cd11b	NN	NN	_	13	compound	_	_
13	antigen	antigen	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	myeloid	myeloid	JJ	JJ	_	17	amod	_	_
16	leukemic	leukemic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	RA	ra	NN	NN	_	7	nsubj	_	_
5	alone	alone	RB	RB	_	4	advmod	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	induce	induce	VB	VB	_	0	root	_	_
8	G1	g1	NN	NN	_	9	compound	_	_
9	arrest	arrest	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	UF-1	uf-1	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	;	;	:	:	_	7	punct	_	_
14	however	however	RB	RB	_	7	advmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	it	it	PRP	PRP	_	19	nsubj	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	result	result	VB	VB	_	7	dep	_	_
20	in	in	IN	IN	_	22	case	_	_
21	an	a	DT	DT	_	22	det	_	_
22	increase	increase	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	p21(WAF1/CIP1)	p21(waf1/cip1)	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	p27(KIP1)	p27(kip1)	NN	NN	_	27	compound	_	_
27	transcript	transcript	NN	NN	_	24	conj	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	24	conj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	RA-resistant	ra-resistant	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	22	nmod	_	_
34	.	.	.	.	_	7	punct	_	_

1	Taken	take	VBN	VBN	_	5	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	conclude	conclude	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	5	ccomp	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cdk	cdk	NN	NN	_	13	compound	_	_
13	inhibitors	inhibitor	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	mediates	mediate	VBZ	VBZ	_	10	acl:relcl	_	_
17	a	a	DT	DT	_	19	det	_	_
18	G1	g1	NN	NN	_	19	compound	_	_
19	arrest	arrest	NN	NN	_	16	dobj	_	_
20	,	,	,	,	_	5	punct	_	_
21	and	and	CC	CC	_	5	cc	_	_
22	this	this	DT	DT	_	25	nsubjpass	_	_
23	may	may	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	associated	associate	VBN	VBN	_	5	conj	_	_
26	with	with	IN	IN	_	27	case	_	_
27	differentiation	differentiation	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	RA-resistant	ra-resistant	JJ	JJ	_	31	amod	_	_
30	UF-1	uf-1	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	toward	toward	IN	IN	_	34	case	_	_
33	mature	mature	JJ	JJ	_	34	amod	_	_
34	granulocytes	granulocyte	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	nmod:npmod	_	_
3	virus-associated	virus-associated	JJ	JJ	_	6	amod	_	_
4	Hodgkin	hodgkin	NN	NN	_	6	nmod:poss	_	_
5	's	's	POS	POS	_	4	case	_	_
6	disease	disease	NN	NN	_	7	nsubj	_	_
7	derives	derive	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	12	case	_	_
9	post-germinal	post-germinal	JJ	JJ	_	12	amod	_	_
10	center	center	JJ	JJ	_	12	amod	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	immunodeficiency	immunodeficiency	NN	NN	_	3	nmod:npmod	_	_
3	virus-associated	virus-associated	JJ	JJ	_	6	amod	_	_
4	Hodgkin	hodgkin	NN	NN	_	6	nmod:poss	_	_
5	's	's	POS	POS	_	4	case	_	_
6	disease	disease	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HIV-HD	hiv-hd	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	displays	display	VBZ	VBZ	_	0	root	_	_
11	several	several	JJ	JJ	_	12	amod	_	_
12	peculiarities	peculiarity	NNS	NNS	_	10	dobj	_	_
13	when	when	WRB	WRB	_	14	advmod	_	_
14	compared	compare	VBN	VBN	_	10	advcl	_	_
15	with	with	IN	IN	_	16	case	_	_
16	HD	hd	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	general	general	JJ	JJ	_	20	amod	_	_
20	population	population	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	include	include	VBP	VBP	_	0	root	_	_
3	overrepresentation	overrepresentation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	clinically	clinically	RB	RB	_	6	advmod	_	_
6	aggressive	aggressive	JJ	JJ	_	8	amod	_	_
7	histologic	histologic	JJ	JJ	_	8	amod	_	_
8	types	type	NNS	NNS	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	frequent	frequent	JJ	JJ	_	11	amod	_	_
11	infection	infection	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	Reed-Sternberg	reed-sternberg	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	RS	rs	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	cells	cell	NNS	NNS	_	8	nmod	_	_
18	by	by	IN	IN	_	20	case	_	_
19	Epstein-Barr	epstein-barr	JJ	JJ	_	20	amod	_	_
20	virus	virus	NN	NN	_	3	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	EBV	ebv	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	2	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	reported	report	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	histogenesis	histogenesis	NN	NN	_	17	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	HD	hd	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	general	general	JJ	JJ	_	14	amod	_	_
14	population	population	NN	NN	_	10	nmod	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	assessed	assess	VBN	VBN	_	5	ccomp	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	monitoring	monitor	VBG	VBG	_	17	advcl	_	_
20	the	the	DT	DT	_	22	det	_	_
21	expression	expression	NN	NN	_	22	compound	_	_
22	pattern	pattern	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	BCL-6	bcl-6	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	a	a	DT	DT	_	28	det	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	24	appos	_	_
29	expressed	express	VBN	VBN	_	28	acl	_	_
30	in	in	IN	IN	_	37	case	_	_
31	germinal	germinal	JJ	JJ	_	37	amod	_	_
32	center	center	NN	NN	_	37	compound	_	_
33	(	(	-LRB-	-LRB-	_	37	punct	_	_
34	GC	gc	NN	NN	_	37	compound	_	_
35	)	)	-RRB-	-RRB-	_	37	punct	_	_
36	B	b	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	29	nmod	_	_
38	,	,	,	,	_	24	punct	_	_
39	and	and	CC	CC	_	24	cc	_	_
40	of	of	IN	IN	_	41	case	_	_
41	CD138/syndecan-1	cd138/syndecan-1	NN	NN	_	24	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	syn-1	syn-1	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	41	punct	_	_
46	a	a	DT	DT	_	47	det	_	_
47	proteoglycan	proteoglycan	NN	NN	_	41	appos	_	_
48	associated	associate	VBN	VBN	_	47	acl	_	_
49	with	with	IN	IN	_	54	case	_	_
50	post-GC	post-gc	JJ	JJ	_	54	amod	_	_
51	,	,	,	,	_	50	punct	_	_
52	terminal	terminal	JJ	JJ	_	50	dep	_	_
53	B-cell	b-cell	NN	NN	_	54	compound	_	_
54	differentiation	differentiation	NN	NN	_	48	nmod	_	_
55	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	applied	apply	VBN	VBN	_	0	root	_	_
8	these	these	DT	DT	_	10	det	_	_
9	two	two	CD	CD	_	10	nummod	_	_
10	markers	marker	NNS	NNS	_	7	dobj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	study	study	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HIV-HD	hiv-hd	NN	NN	_	16	compound	_	_
16	histogenesis	histogenesis	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	correlated	correlate	VBN	VBN	_	7	conj	_	_
19	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	status	status	NN	NN	_	18	dobj	_	_
22	to	to	TO	TO	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	virologic	virologic	JJ	JJ	_	25	amod	_	_
25	features	feature	NNS	NNS	_	18	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	this	this	DT	DT	_	28	det	_	_
28	disease	disease	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	RS	rs	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	all	all	DT	DT	_	10	det	_	_
9	histologic	histologic	JJ	JJ	_	10	amod	_	_
10	categories	category	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HIV-HD	hiv-hd	NN	NN	_	10	nmod	_	_
13	consistently	consistently	RB	RB	_	14	advmod	_	_
14	display	display	VBP	VBP	_	3	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	BCL-6(-)/syn-1(+)	bcl-6(-)/syn-1(+)	JJ	JJ	_	17	amod	_	_
17	phenotype	phenotype	NN	NN	_	14	dobj	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	thus	thus	RB	RB	_	14	advmod	_	_
20	reflect	reflect	VBP	VBP	_	14	dep	_	_
21	post-GC	post-gc	JJ	JJ	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	BCL-6(-)/syn-1(+)	bcl-6(-)/syn-1(+)	JJ	JJ	_	4	amod	_	_
3	RS	rs	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	HIV-HD	hiv-hd	NN	NN	_	4	nmod	_	_
7	express	express	VBP	VBP	_	13	advcl	_	_
8	CD40	cd40	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	13	punct	_	_
10	they	they	PRP	PRP	_	13	nsubjpass	_	_
11	are	be	VBP	VBP	_	13	auxpass	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	surrounded	surround	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	22	case	_	_
15	CD40	cd40	NN	NN	_	22	compound	_	_
16	ligand-positive	ligand-positive	JJ	JJ	_	22	amod	_	_
17	(	(	-LRB-	-LRB-	_	22	punct	_	_
18	CD40L+	cd40l+	JJ	JJ	_	22	amod	_	_
19	)	)	-RRB-	-RRB-	_	22	punct	_	_
20	reactive	reactive	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	34	nsubjpass	_	_
25	,	,	,	,	_	34	punct	_	_
26	in	in	IN	IN	_	27	case	_	_
27	HD	hd	NN	NN	_	34	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	general	general	JJ	JJ	_	31	amod	_	_
31	population	population	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	34	punct	_	_
33	are	be	VBP	VBP	_	34	auxpass	_	_
34	thought	think	VBN	VBN	_	22	acl:relcl	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	regulate	regulate	VB	VB	_	34	xcomp	_	_
37	the	the	DT	DT	_	39	det	_	_
38	disease	disease	NN	NN	_	39	compound	_	_
39	phenotype	phenotype	NN	NN	_	36	dobj	_	_
40	through	through	IN	IN	_	42	case	_	_
41	CD40/CD40L	cd40/cd40l	NN	NN	_	42	amod	_	_
42	interactions	interaction	NNS	NNS	_	36	nmod	_	_
43	.	.	.	.	_	13	punct	_	_

1	Conversely	conversely	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	RS	rs	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	virtually	virtually	RB	RB	_	7	advmod	_	_
7	all	all	DT	DT	_	8	amod	_	_
8	HIV-HD	hiv-hd	NN	NN	_	4	nmod	_	_
9	express	express	VBP	VBP	_	0	root	_	_
10	the	the	DT	DT	_	14	det	_	_
11	EBV-encoded	ebv-encoded	JJ	JJ	_	14	amod	_	_
12	latent	latent	JJ	JJ	_	14	amod	_	_
13	membrane	membrane	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	9	dobj	_	_
15	1	1	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	LMP1	lmp1	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	14	punct	_	_
20	which	which	WDT	WDT	_	29	nsubj	_	_
21	,	,	,	,	_	29	punct	_	_
22	being	be	VBG	VBG	_	24	cop	_	_
23	functionally	functionally	RB	RB	_	24	advmod	_	_
24	homologous	homologous	JJ	JJ	_	29	dep	_	_
25	to	to	TO	TO	_	26	case	_	_
26	CD40	cd40	NN	NN	_	24	nmod	_	_
27	,	,	,	,	_	29	punct	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	contribute	contribute	VB	VB	_	14	acl:relcl	_	_
30	,	,	,	,	_	29	punct	_	_
31	at	at	IN	IN	_	34	advmod	_	_
32	least	least	JJS	JJS	_	31	mwe	_	_
33	in	in	IN	IN	_	34	case	_	_
34	part	part	NN	NN	_	29	nmod	_	_
35	,	,	,	,	_	29	punct	_	_
36	to	to	TO	TO	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	modulation	modulation	NN	NN	_	29	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	HIV-HD	hiv-hd	NN	NN	_	42	compound	_	_
42	phenotype	phenotype	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	9	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	10	case	_	_
6	primary	primary	JJ	JJ	_	10	amod	_	_
7	adult	adult	JJ	JJ	_	10	amod	_	_
8	T-cell	t-cell	NN	NN	_	10	compound	_	_
9	leukemia	leukemia	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	13	nsubj	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-I	htlv-i	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	etiologic	etiologic	JJ	JJ	_	13	amod	_	_
13	agent	agent	NN	NN	_	0	root	_	_
14	of	of	IN	IN	_	17	case	_	_
15	adult	adult	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATL	atl	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	viral	viral	JJ	JJ	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	Tax	tax	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	activation	activation	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocalization	translocalization	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	7	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	proposed	propose	VBN	VBN	_	14	acl:relcl	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	play	play	VB	VB	_	18	xcomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	crucial	crucial	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	transformation	transformation	NN	NN	_	20	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	HTLV-I	htlv-i	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	HTLV-I	htlv-i	NN	NN	_	5	compound	_	_
5	genes	gene	NNS	NNS	_	10	nsubjpass	_	_
6	including	include	VBG	VBG	_	7	case	_	_
7	Tax	tax	NN	NN	_	5	nmod	_	_
8	are	be	VBP	VBP	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	primary	primary	JJ	JJ	_	15	amod	_	_
14	leukemic	leukemic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	from	from	IN	IN	_	18	case	_	_
17	ATL	atl	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	basis	basis	NN	NN	_	6	dobj	_	_
9	for	for	IN	IN	_	11	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	freshly	freshly	RB	RB	_	16	advmod	_	_
14	isolated	isolate	VBN	VBN	_	16	amod	_	_
15	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	ATL	atl	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	leukemic	leukemic	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	15	nsubj	_	_
6	from	from	IN	IN	_	8	case	_	_
7	ATL	atl	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	15	punct	_	_
10	like	like	IN	IN	_	13	case	_	_
11	HTLV-I-infected	htlv-i-infected	JJ	JJ	_	13	amod	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	15	nmod	_	_
14	,	,	,	,	_	15	punct	_	_
15	display	display	VBP	VBP	_	2	ccomp	_	_
16	constitutive	constitutive	JJ	JJ	_	20	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
18	DNA	dna	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	15	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	increased	increase	VBN	VBN	_	23	amod	_	_
23	degradation	degradation	NN	NN	_	20	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	IkappaBalpha	ikappabalpha	NN	NN	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	an	a	DT	DT	_	28	det	_	_
28	inhibitor	inhibitor	NN	NN	_	25	dep	_	_
29	of	of	IN	IN	_	30	case	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	28	nmod	_	_
31	)	)	-RRB-	-RRB-	_	28	punct	_	_
32	.	.	.	.	_	2	punct	_	_

1	Whereas	whereas	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	5	det	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
4	binding	binding	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	10	nsubj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	Tax-expressing	tax-expressing	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	lines	line	NNS	NNS	_	5	nmod	_	_
10	consisted	consist	VBD	VBD	_	18	advcl	_	_
11	mostly	mostly	RB	RB	_	13	advmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p50/c-Rel	p50/c-rel	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	fresh	fresh	JJ	JJ	_	17	amod	_	_
16	ATL	atl	NN	NN	_	17	compound	_	_
17	samples	sample	NNS	NNS	_	18	nsubj	_	_
18	contained	contain	VBD	VBD	_	0	root	_	_
19	p50/p50	p50/p50	NN	NN	_	22	compound	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	p50/p65	p50/p65	NN	NN	_	19	conj	_	_
22	heterodimers	heterodimer	NNS	NNS	_	18	dobj	_	_
23	.	.	.	.	_	18	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	line	line	NN	NN	_	12	nsubj	_	_
4	derived	derive	VBN	VBN	_	3	acl	_	_
5	from	from	IN	IN	_	8	case	_	_
6	ATL	atl	NN	NN	_	8	compound	_	_
7	leukemic	leukemic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	TL-Om1	tl-om1	NN	NN	_	3	appos	_	_
11	,	,	,	,	_	3	punct	_	_
12	displayed	display	VBD	VBD	_	0	root	_	_
13	constitutive	constitutive	JJ	JJ	_	15	amod	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	as	as	RB	RB	_	15	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	enhanced	enhance	VBN	VBN	_	21	amod	_	_
21	degradation	degradation	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IkappaBalpha	ikappabalpha	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	15	punct	_	_
25	despite	despite	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	lack	lack	NN	NN	_	12	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	detectable	detectable	JJ	JJ	_	31	amod	_	_
30	Tax	tax	NN	NN	_	31	compound	_	_
31	expression	expression	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	Interestingly	interestingly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	7	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	TL-Om1	tl-om1	NN	NN	_	4	nmod	_	_
7	consists	consist	VBZ	VBZ	_	0	root	_	_
8	of	of	IN	IN	_	9	case	_	_
9	p50/p50	p50/p50	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p50/p65	p50/p65	NN	NN	_	9	conj	_	_
12	like	like	IN	IN	_	13	case	_	_
13	that	that	DT	DT	_	7	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	fresh	fresh	JJ	JJ	_	18	amod	_	_
16	primary	primary	JJ	JJ	_	18	amod	_	_
17	leukemic	leukemic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	activation	activation	NN	NN	_	8	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	occurs	occur	VBZ	VBZ	_	3	ccomp	_	_
9	through	through	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	Tax-independent	tax-independent	JJ	JJ	_	12	amod	_	_
12	mechanism	mechanism	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	leukemic	leukemic	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	ATL	atl	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	possibly	possibly	RB	RB	_	26	advmod	_	_
21	due	due	JJ	JJ	_	26	case	_	_
22	to	to	TO	TO	_	21	mwe	_	_
23	differential	differential	JJ	JJ	_	26	amod	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
25	subunit	subunit	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	8	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Apoptosis-resistant	apoptosis-resistant	JJ	JJ	_	3	amod	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	have	have	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	deficiency	deficiency	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	9	amod	_	_
9	induction	induction	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	Fas	fas	NN	NN	_	13	compound	_	_
12	ligand	ligand	NN	NN	_	13	compound	_	_
13	transcription	transcription	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	12	nsubjpass	_	_
2	induced	induce	VBN	VBN	_	1	acl	_	_
3	through	through	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	TCR	tcr	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	CD4+	cd4+	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	mostly	mostly	RB	RB	_	12	advmod	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	inducible	inducible	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	Fas	fas	NN	NN	_	19	compound	_	_
19	ligand	ligand	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	FasL	fasl	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	as	as	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	primary	primary	JJ	JJ	_	26	amod	_	_
26	event	event	NN	NN	_	12	nmod	_	_
27	leading	lead	VBG	VBG	_	26	acl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	commitment	commitment	NN	NN	_	27	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	death	death	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	16	advcl	_	_
3	a	a	DT	DT	_	5	det	_	_
4	better	better	JJR	JJR	_	5	amod	_	_
5	understanding	understanding	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	events	event	NNS	NNS	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	regulate	regulate	VBP	VBP	_	9	acl:relcl	_	_
12	this	this	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	took	take	VBD	VBD	_	0	root	_	_
17	advantage	advantage	NN	NN	_	16	dobj	_	_
18	of	of	IN	IN	_	24	case	_	_
19	our	we	PRP$	PRP$	_	24	nmod:poss	_	_
20	previously	previously	RB	RB	_	21	advmod	_	_
21	described	describe	VBN	VBN	_	24	amod	_	_
22	mutant	mutant	JJ	JJ	_	24	amod	_	_
23	Jurkat	jurkat	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	17	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	deficient	deficient	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	FasL	fasl	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	apoptosis	apoptosis	NN	NN	_	7	conj	_	_
10	induced	induce	VBN	VBN	_	9	acl	_	_
11	upon	upon	IN	IN	_	13	case	_	_
12	TCR	tcr	NN	NN	_	13	compound	_	_
13	triggering	triggering	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	4	punct	_	_
15	although	although	IN	IN	_	25	mark	_	_
16	their	they	PRP$	PRP$	_	23	nmod:poss	_	_
17	cytokine	cytokine	NN	NN	_	23	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	IL-2	il-2	NN	NN	_	17	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	19	conj	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	production	production	NN	NN	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	normal	normal	JJ	JJ	_	4	advcl	_	_
26	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	both	both	CC	CC	_	7	cc:preconj	_	_
6	a	a	DT	DT	_	7	det	_	_
7	FasL-	fasl-	NN	NN	_	15	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	a	a	DT	DT	_	11	det	_	_
10	consensus	consensus	NN	NN	_	11	compound	_	_
11	NF-kappaB-reporter	nf-kappab-reporter	NN	NN	_	7	conj	_	_
12	construct	construct	NN	NN	_	7	dep	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	inefficiently	inefficiently	RB	RB	_	15	advmod	_	_
15	induced	induce	VBN	VBN	_	3	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	these	these	DT	DT	_	18	det	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	compared	compare	VBN	VBN	_	22	case	_	_
20	to	to	TO	TO	_	22	case	_	_
21	wild-type	wild-type	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	15	advcl	_	_
23	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	inducible	inducible	JJ	JJ	_	10	amod	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activity	activity	NN	NN	_	16	nsubjpass	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	FasL	fasl	NN	NN	_	14	compound	_	_
14	reporter	reporter	NN	NN	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	abolished	abolish	VBN	VBN	_	5	ccomp	_	_
17	by	by	IN	IN	_	19	case	_	_
18	specific	specific	JJ	JJ	_	19	amod	_	_
19	inhibitors	inhibitor	NNS	NNS	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	could	could	MD	MD	_	5	aux	_	_
5	trace	trace	VB	VB	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	deficit	deficit	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	mutant	mutant	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	inefficient	inefficient	JJ	JJ	_	16	amod	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	5	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	evidencing	evidence	VBG	VBG	_	5	advcl	_	_
19	a	a	DT	DT	_	21	det	_	_
20	relevant	relevant	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	regulation	regulation	NN	NN	_	21	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	FasL	fasl	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	33	case	_	_
31	activated	activate	VBN	VBN	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	induction	induction	NN	NN	_	17	nsubj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	FasL	fasl	NN	NN	_	14	compound	_	_
11	versus	versus	CC	CC	_	10	cc	_	_
12	cytokine	cytokine	NN	NN	_	10	conj	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	8	nmod	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	differentially	differentially	RB	RB	_	17	advmod	_	_
17	sensitive	sensitive	JJ	JJ	_	5	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	deprivation	deprivation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	nsubj	_	_
2	regulates	regulate	VBZ	VBZ	_	0	root	_	_
3	Fas/APO-1/CD95-	fas/apo-1/cd95-	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	TCR-mediated	tcr-mediated	JJ	JJ	_	6	amod	_	_
6	apoptosis	apoptosis	NN	NN	_	3	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	maintenance	maintenance	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	lymphocyte	lymphocyte	NN	NN	_	5	compound	_	_
5	homeostasis	homeostasis	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	12	cop	_	_
9	a	a	DT	DT	_	12	det	_	_
10	critical	critical	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	mechanism	mechanism	NN	NN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	system	system	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	transcription	transcription	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	play	play	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	protecting	protect	VBG	VBG	_	9	advcl	_	_
14	cells	cell	NNS	NNS	_	13	dobj	_	_
15	against	against	IN	IN	_	16	case	_	_
16	death	death	NN	NN	_	13	nmod	_	_
17	mediated	mediate	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	TNF	tnf	NN	NN	_	17	nmod	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	has	have	VBZ	VBZ	_	2	ccomp	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	11	mark	_	_
11	regulating	regulate	VBG	VBG	_	7	advcl	_	_
12	Fas/APO-1/CD95-mediated	fas/apo-1/cd95-mediated	JJ	JJ	_	13	amod	_	_
13	death	death	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	major	major	JJ	JJ	_	17	amod	_	_
17	pathway	pathway	NN	NN	_	13	appos	_	_
18	of	of	IN	IN	_	22	case	_	_
19	peripheral	peripheral	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	death	death	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Transfection	transfection	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Jurkat	jurkat	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	8	amod	_	_
6	the	the	DT	DT	_	8	det	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	subunits	subunit	NNS	NNS	_	1	dep	_	_
9	p50	p50	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	p65	p65	NN	NN	_	9	conj	_	_
12	confers	confer	VBZ	VBZ	_	0	root	_	_
13	resistance	resistance	NN	NN	_	12	dobj	_	_
14	against	against	IN	IN	_	16	case	_	_
15	Fas-mediated	fas-mediated	JJ	JJ	_	16	amod	_	_
16	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Reciprocally	reciprocally	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	inhibition	inhibition	NN	NN	_	23	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	soluble	soluble	JJ	JJ	_	11	amod	_	_
10	peptide	peptide	NN	NN	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	3	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	a	a	DT	DT	_	15	det	_	_
14	dominant	dominant	JJ	JJ	_	15	amod	_	_
15	form	form	NN	NN	_	11	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	inhibitor	inhibitor	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	IkappaB	ikappab	NN	NN	_	15	appos	_	_
22	,	,	,	,	_	15	punct	_	_
23	makes	make	VBZ	VBZ	_	0	root	_	_
24	the	the	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	27	nsubj	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	susceptible	susceptible	JJ	JJ	_	23	xcomp	_	_
28	to	to	TO	TO	_	30	case	_	_
29	Fas-mediated	fas-mediated	JJ	JJ	_	30	amod	_	_
30	apoptosis	apoptosis	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	23	punct	_	_

1	Furthermore	furthermore	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	soluble	soluble	JJ	JJ	_	11	amod	_	_
10	peptide	peptide	NN	NN	_	11	compound	_	_
11	inhibitor	inhibitor	NN	NN	_	3	nmod	_	_
12	rendered	render	VBD	VBD	_	0	root	_	_
13	a	a	DT	DT	_	16	det	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	hybridoma	hybridoma	NN	NN	_	18	nsubj	_	_
17	more	more	RBR	RBR	_	18	advmod	_	_
18	susceptible	susceptible	JJ	JJ	_	12	xcomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	TCR-mediated	tcr-mediated	JJ	JJ	_	21	amod	_	_
21	apoptosis	apoptosis	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Correspondingly	correspondingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	transfection	transfection	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	p50	p50	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p65	p65	NN	NN	_	5	conj	_	_
8	provided	provide	VBD	VBD	_	0	root	_	_
9	considerable	considerable	JJ	JJ	_	10	amod	_	_
10	protection	protection	NN	NN	_	8	dobj	_	_
11	from	from	IN	IN	_	13	case	_	_
12	TCR-mediated	tcr-mediated	JJ	JJ	_	13	amod	_	_
13	apoptosis	apoptosis	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	corroborated	corroborate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	studies	study	NNS	NNS	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	Fas-mediated	fas-mediated	JJ	JJ	_	9	amod	_	_
9	death	death	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	primary	primary	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Concanavalin	concanavalin	NN	NN	_	6	compound	_	_
2	A-activated	a-activated	JJ	JJ	_	6	amod	_	_
3	cycling	cycling	NN	NN	_	6	compound	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	blasts	blast	NNS	NNS	_	18	nsubj	_	_
7	from	from	IN	IN	_	8	case	_	_
8	mice	mouse	NNS	NNS	_	6	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubj	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	transgenic	transgenic	JJ	JJ	_	8	acl:relcl	_	_
12	for	for	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	dominant	dominant	JJ	JJ	_	16	amod	_	_
15	IkappaB	ikappab	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	11	nmod	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	increased	increase	VBN	VBN	_	0	root	_	_
19	sensitivity	sensitivity	NN	NN	_	18	dobj	_	_
20	to	to	TO	TO	_	22	case	_	_
21	Fas-mediated	fas-mediated	JJ	JJ	_	22	amod	_	_
22	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	18	punct	_	_
24	associated	associate	VBN	VBN	_	18	advcl	_	_
25	with	with	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	down-regulation	down-regulation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	NF-kappaB	nf-kappab	NN	NN	_	30	compound	_	_
30	complexes	complex	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	nucleus	nucleus	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	17	nmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	blocking	block	VBG	VBG	_	17	csubj	_	_
5	TNF	tnf	NN	NN	_	4	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	itself	itself	PRP	PRP	_	5	appos	_	_
8	a	a	DT	DT	_	10	det	_	_
9	positive	positive	JJ	JJ	_	10	amod	_	_
10	regulator	regulator	NN	NN	_	7	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	with	with	IN	IN	_	16	case	_	_
15	neutralizing	neutralize	VBG	VBG	_	16	amod	_	_
16	antibodies	antibody	NNS	NNS	_	4	nmod	_	_
17	renders	render	VBZ	VBZ	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	21	nsubj	_	_
20	more	more	RBR	RBR	_	21	advmod	_	_
21	susceptible	susceptible	JJ	JJ	_	17	xcomp	_	_
22	to	to	TO	TO	_	24	case	_	_
23	anti-Fas-mediated	anti-fas-mediated	JJ	JJ	_	24	amod	_	_
24	apoptosis	apoptosis	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	compelling	compelling	JJ	JJ	_	8	amod	_	_
8	evidence	evidence	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	nsubj	_	_
11	protects	protect	VBZ	VBZ	_	8	ccomp	_	_
12	against	against	IN	IN	_	14	case	_	_
13	Fas-mediated	fas-mediated	JJ	JJ	_	14	amod	_	_
14	death	death	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	likely	likely	JJ	JJ	_	11	conj	_	_
18	to	to	TO	TO	_	22	mark	_	_
19	be	be	VB	VB	_	22	cop	_	_
20	an	a	DT	DT	_	22	det	_	_
21	important	important	JJ	JJ	_	22	amod	_	_
22	regulator	regulator	NN	NN	_	17	xcomp	_	_
23	of	of	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	homeostasis	homeostasis	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	tolerance	tolerance	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Interferon-beta	interferon-beta	NN	NN	_	2	nsubj	_	_
2	mediates	mediate	VBZ	VBZ	_	0	root	_	_
3	stromal	stromal	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	rescue	rescue	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	resolution	resolution	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	responses	response	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	characterized	characterize	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	extensive	extensive	JJ	JJ	_	10	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	generate	generate	VB	VB	_	15	advcl	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	maintain	maintain	VB	VB	_	4	conj	_	_
7	immunological	immunological	JJ	JJ	_	8	amod	_	_
8	memory	memory	NN	NN	_	4	dobj	_	_
9	,	,	,	,	_	15	punct	_	_
10	some	some	DT	DT	_	13	det	_	_
11	antigen-specific	antigen-specific	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	15	nsubj	_	_
14	must	must	MD	MD	_	15	aux	_	_
15	survive	survive	VB	VB	_	0	root	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	revert	revert	VB	VB	_	15	conj	_	_
18	to	to	TO	TO	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	resting	resting	JJ	JJ	_	22	amod	_	_
21	G0/G1	g0/g1	NN	NN	_	22	compound	_	_
22	state	state	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Cytokines	cytokine	NNS	NNS	_	13	nsubj	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	bind	bind	VBP	VBP	_	1	acl:relcl	_	_
4	to	to	TO	TO	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	common	common	JJ	JJ	_	8	amod	_	_
7	gamma	gamma	NN	NN	_	8	compound	_	_
8	chain	chain	NN	NN	_	3	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	receptor	receptor	NN	NN	_	8	nmod	_	_
13	promote	promote	VBP	VBP	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	survival	survival	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	blasts	blast	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	but	but	CC	CC	_	13	cc	_	_
22	also	also	RB	RB	_	23	advmod	_	_
23	induce	induce	VBP	VBP	_	13	conj	_	_
24	proliferation	proliferation	NN	NN	_	23	dobj	_	_
25	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	soluble	soluble	JJ	JJ	_	5	amod	_	_
5	factors	factor	NNS	NNS	_	10	nsubj	_	_
6	secreted	secrete	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	9	case	_	_
8	stromal	stromal	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	induce	induce	VBP	VBP	_	0	root	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	survival	survival	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	resting	resting	JJ	JJ	_	18	amod	_	_
17	G0/G1	g0/g1	NN	NN	_	18	compound	_	_
18	state	state	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	interferon-beta	interferon-beta	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	the	the	DT	DT	_	9	det	_	_
8	principal	principal	JJ	JJ	_	9	amod	_	_
9	mediator	mediator	NN	NN	_	3	ccomp	_	_
10	of	of	IN	IN	_	15	case	_	_
11	stromal	stromal	JJ	JJ	_	12	amod	_	_
12	cell-mediated	cell-mediated	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	rescue	rescue	NN	NN	_	9	nmod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	apoptosis	apoptosis	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Interferon-alpha	interferon-alpha	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	-beta	-beta	NN	NN	_	1	conj	_	_
4	promote	promote	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	reversion	reversion	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	blast	blast	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	to	to	TO	TO	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	resting	rest	VBG	VBG	_	15	amod	_	_
14	G0/G1	g0/g1	NN	NN	_	15	compound	_	_
15	configuration	configuration	NN	NN	_	6	nmod	_	_
16	with	with	IN	IN	_	20	case	_	_
17	all	all	PDT	PDT	_	20	det:predet	_	_
18	the	the	DT	DT	_	20	det	_	_
19	characteristic	characteristic	JJ	JJ	_	20	amod	_	_
20	features	feature	NNS	NNS	_	15	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	stromal	stromal	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	rescue	rescue	NN	NN	_	20	nmod	_	_
25	;	;	:	:	_	20	punct	_	_
26	such	such	JJ	JJ	_	30	case	_	_
27	as	as	IN	IN	_	26	mwe	_	_
28	high	high	JJ	JJ	_	30	amod	_	_
29	Bcl-XL	bcl-xl	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	20	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	low	low	JJ	JJ	_	33	amod	_	_
33	Bcl-2	bcl-2	NN	NN	_	30	conj	_	_
34	.	.	.	.	_	4	punct	_	_

1	Type	type	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	3	nummod	_	_
3	interferons	interferon	NNS	NNS	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	stromal	stromal	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	conj	_	_
7	stimulate	stimulate	VBP	VBP	_	0	root	_	_
8	apparently	apparently	RB	RB	_	9	advmod	_	_
9	identical	identical	JJ	JJ	_	11	amod	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathways	pathway	NNS	NNS	_	7	dobj	_	_
12	,	,	,	,	_	7	punct	_	_
13	leading	lead	VBG	VBG	_	7	advcl	_	_
14	to	to	TO	TO	_	16	case	_	_
15	STAT-1	stat-1	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	play	play	VB	VB	_	3	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	fundamental	fundamental	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	persistence	persistence	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	at	at	IN	IN	_	19	case	_	_
19	sites	site	NNS	NNS	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	chronic	chronic	JJ	JJ	_	22	amod	_	_
22	inflammation	inflammation	NN	NN	_	19	nmod	_	_
23	;	;	:	:	_	8	punct	_	_
24	suggesting	suggest	VBG	VBG	_	8	parataxis	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	chronic	chronic	JJ	JJ	_	27	amod	_	_
27	inflammation	inflammation	NN	NN	_	31	nsubj	_	_
28	is	be	VBZ	VBZ	_	31	cop	_	_
29	an	a	DT	DT	_	31	det	_	_
30	aberrant	aberrant	JJ	JJ	_	31	amod	_	_
31	consequence	consequence	NN	NN	_	24	ccomp	_	_
32	of	of	IN	IN	_	34	case	_	_
33	immunological	immunological	JJ	JJ	_	34	amod	_	_
34	memory	memory	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	6	case	_	_
3	distinct	distinct	JJ	JJ	_	6	amod	_	_
4	intracellular	intracellular	JJ	JJ	_	6	amod	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	pathways	pathway	NNS	NNS	_	1	nmod	_	_
7	in	in	IN	IN	_	13	case	_	_
8	CD34+	cd34+	JJ	JJ	_	9	amod	_	_
9	progenitor	progenitor	NN	NN	_	13	compound	_	_
10	to	to	TO	TO	_	9	dep	_	_
11	dendritic	dendritic	JJ	JJ	_	12	amod	_	_
12	cell	cell	NN	NN	_	9	dep	_	_
13	differentiation	differentiation	NN	NN	_	1	nmod	_	_
14	from	from	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	line	line	NN	NN	_	19	compound	_	_
19	model	model	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Intracellular	intracellular	JJ	JJ	_	2	amod	_	_
2	signals	signal	NNS	NNS	_	18	nsubj	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	mediate	mediate	VBP	VBP	_	2	acl:relcl	_	_
5	differentiation	differentiation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	pluripotent	pluripotent	JJ	JJ	_	9	amod	_	_
8	hemopoietic	hemopoietic	JJ	JJ	_	9	amod	_	_
9	progenitors	progenitor	NNS	NNS	_	5	nmod	_	_
10	to	to	TO	TO	_	12	case	_	_
11	dendritic	dendritic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	DC	dc	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	are	be	VBP	VBP	_	18	cop	_	_
17	largely	largely	RB	RB	_	18	advmod	_	_
18	undefined	undefined	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	23	mark	_	_
6	protein	protein	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	C	c	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PKC	pkc	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	activation	activation	NN	NN	_	23	nsubj	_	_
13	(	(	-LRB-	-LRB-	_	12	punct	_	_
14	with	with	IN	IN	_	16	case	_	_
15	phorbol	phorbol	NN	NN	_	16	compound	_	_
16	ester	ester	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PMA	pma	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	alone	alone	RB	RB	_	16	advmod	_	_
21	)	)	-RRB-	-RRB-	_	12	punct	_	_
22	specifically	specifically	RB	RB	_	23	advmod	_	_
23	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
24	differentiation	differentiation	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	31	case	_	_
26	primary	primary	JJ	JJ	_	31	amod	_	_
27	human	human	JJ	JJ	_	31	amod	_	_
28	CD34+	cd34+	JJ	JJ	_	31	amod	_	_
29	hemopoietic	hemopoietic	JJ	JJ	_	31	amod	_	_
30	progenitor	progenitor	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	24	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	HPC	hpc	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	to	to	TO	TO	_	37	case	_	_
36	mature	mature	JJ	JJ	_	37	amod	_	_
37	DC	dc	NN	NN	_	24	nmod	_	_
38	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	find	find	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	cytokine-driven	cytokine-driven	JJ	JJ	_	16	amod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	8	amod	_	_
8	CSF	csf	NN	NN	_	16	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	TNF-alpha	tnf-alpha	NN	NN	_	8	conj	_	_
11	)	)	-RRB-	-RRB-	_	8	punct	_	_
12	CD34+	cd34+	JJ	JJ	_	13	amod	_	_
13	HPC	hpc	NN	NN	_	16	compound	_	_
14	--&gt;	--&gt;	TO	TO	_	13	dep	_	_
15	DC	dc	NN	NN	_	13	dep	_	_
16	differentiation	differentiation	NN	NN	_	19	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	19	auxpass	_	_
18	preferentially	preferentially	RB	RB	_	19	advmod	_	_
19	blocked	block	VBN	VBN	_	3	ccomp	_	_
20	by	by	IN	IN	_	21	case	_	_
21	inhibitors	inhibitor	NNS	NNS	_	19	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	PKC	pkc	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	identify	identify	VB	VB	_	18	dep	_	_
4	intracellular	intracellular	JJ	JJ	_	5	amod	_	_
5	signals	signal	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	downstream	downstream	JJ	JJ	_	8	amod	_	_
8	events	event	NNS	NNS	_	5	conj	_	_
9	important	important	JJ	JJ	_	5	amod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	CD34+	cd34+	JJ	JJ	_	12	amod	_	_
12	HPC	hpc	NN	NN	_	15	compound	_	_
13	--&gt;	--&gt;	TO	TO	_	12	dep	_	_
14	DC	dc	NN	NN	_	12	dep	_	_
15	differentiation	differentiation	NN	NN	_	9	nmod	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	characterized	characterize	VBN	VBN	_	0	root	_	_
19	a	a	DT	DT	_	24	det	_	_
20	human	human	JJ	JJ	_	24	amod	_	_
21	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	line	line	NN	NN	_	24	compound	_	_
24	model	model	NN	NN	_	18	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	process	process	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	CD34+	cd34+	JJ	JJ	_	6	amod	_	_
3	myelomonocytic	myelomonocytic	JJ	JJ	_	6	amod	_	_
4	cell	cell	NN	NN	_	6	compound	_	_
5	line	line	NN	NN	_	6	compound	_	_
6	KG1	kg1	NN	NN	_	7	nsubj	_	_
7	differentiates	differentiate	VBZ	VBZ	_	0	root	_	_
8	into	into	IN	IN	_	10	case	_	_
9	dendritic-like	dendritic-like	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	response	response	NN	NN	_	15	dep	_	_
13	to	to	TO	TO	_	15	case	_	_
14	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	15	amod	_	_
15	CSF	csf	NN	NN	_	7	nmod	_	_
16	plus	plus	CC	CC	_	15	cc	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	or	or	CC	CC	_	15	cc	_	_
20	PMA	pma	NN	NN	_	15	conj	_	_
21	(	(	-LRB-	-LRB-	_	20	punct	_	_
22	with	with	IN	IN	_	28	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	without	without	IN	IN	_	22	conj	_	_
25	the	the	DT	DT	_	28	det	_	_
26	calcium	calcium	NN	NN	_	28	compound	_	_
27	ionophore	ionophore	NN	NN	_	28	compound	_	_
28	ionomycin	ionomycin	NN	NN	_	20	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	or	or	CC	CC	_	28	cc	_	_
31	TNF-alpha	tnf-alpha	NN	NN	_	28	conj	_	_
32	)	)	-RRB-	-RRB-	_	20	punct	_	_
33	,	,	,	,	_	7	punct	_	_
34	with	with	IN	IN	_	37	mark	_	_
35	different	different	JJ	JJ	_	36	amod	_	_
36	stimuli	stimulus	NNS	NNS	_	37	nsubj	_	_
37	mediating	mediate	VBG	VBG	_	7	advcl	_	_
38	different	different	JJ	JJ	_	39	amod	_	_
39	aspects	aspect	NNS	NNS	_	37	dobj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	process	process	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Phenotypic	phenotypic	JJ	JJ	_	3	amod	_	_
2	DC	dc	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	KG1	kg1	NN	NN	_	7	compound	_	_
6	dendritic-like	dendritic-like	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	include	include	VBP	VBP	_	0	root	_	_
9	morphology	morphology	NN	NN	_	8	dobj	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	loosely	loosely	RB	RB	_	13	advmod	_	_
12	adherent	adherent	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	dep	_	_
14	with	with	IN	IN	_	17	case	_	_
15	long	long	JJ	JJ	_	17	amod	_	_
16	neurite	neurite	NN	NN	_	17	compound	_	_
17	processes	process	NNS	NNS	_	13	nmod	_	_
18	)	)	-RRB-	-RRB-	_	13	punct	_	_
19	,	,	,	,	_	9	punct	_	_
20	MHC	mhc	NN	NN	_	25	compound	_	_
21	I+/MHC	i+/mhc	JJ	JJ	_	25	amod	_	_
22	IIbright/CD83+/CD86+/CD14-	iibright/cd83+/cd86+/cd14-	JJ	JJ	_	25	amod	_	_
23	surface	surface	NN	NN	_	25	compound	_	_
24	Ag	ag	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	9	conj	_	_
26	,	,	,	,	_	9	punct	_	_
27	and	and	CC	CC	_	9	cc	_	_
28	RelB	relb	NN	NN	_	32	compound	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	DC-CK1	dc-ck1	NN	NN	_	28	conj	_	_
31	gene	gene	NN	NN	_	32	compound	_	_
32	expression	expression	NN	NN	_	9	conj	_	_
33	.	.	.	.	_	8	punct	_	_

1	Functional	functional	JJ	JJ	_	3	amod	_	_
2	DC	dc	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	4	nsubj	_	_
4	include	include	VBP	VBP	_	0	root	_	_
5	fluid	fluid	NN	NN	_	8	compound	_	_
6	phase	phase	NN	NN	_	8	compound	_	_
7	macromolecule	macromolecule	NN	NN	_	8	compound	_	_
8	uptake	uptake	NN	NN	_	4	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	FITC-dextran	fitc-dextran	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	activation	activation	NN	NN	_	8	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	resting	rest	VBG	VBG	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	KG1	kg1	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	PMA-unresponsive	pma-unresponsive	JJ	JJ	_	8	amod	_	_
7	subline	subline	NN	NN	_	8	compound	_	_
8	KG1a	kg1a	NN	NN	_	1	nmod	_	_
9	reveals	reveal	VBZ	VBZ	_	0	root	_	_
10	differences	difference	NNS	NNS	_	9	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNF	tnf	NN	NN	_	15	compound	_	_
15	receptors	receptor	NNS	NNS	_	12	nmod	_	_
16	1	1	CD	CD	_	15	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	2	2	CD	CD	_	16	conj	_	_
19	;	;	:	:	_	15	punct	_	_
20	PKC	pkc	NN	NN	_	21	compound	_	_
21	isoforms	isoform	NNS	NNS	_	15	conj	_	_
22	alpha	alpha	NN	NN	_	21	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	beta	beta	NN	NN	_	22	conj	_	_
25	I	i	CD	CD	_	24	nummod	_	_
26	,	,	,	,	_	22	punct	_	_
27	beta	beta	NN	NN	_	22	conj	_	_
28	II	ii	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	22	punct	_	_
30	and	and	CC	CC	_	22	cc	_	_
31	mu	mu	NN	NN	_	22	conj	_	_
32	;	;	:	:	_	15	punct	_	_
33	and	and	CC	CC	_	15	cc	_	_
34	RelB	relb	NN	NN	_	15	conj	_	_
35	,	,	,	,	_	9	punct	_	_
36	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
37	that	that	IN	IN	_	41	mark	_	_
38	these	these	DT	DT	_	39	det	_	_
39	components/pathways	components/pathways	NNS	NNS	_	41	nsubj	_	_
40	are	be	VBP	VBP	_	41	cop	_	_
41	important	important	JJ	JJ	_	36	ccomp	_	_
42	for	for	IN	IN	_	44	case	_	_
43	DC	dc	NN	NN	_	44	compound	_	_
44	differentiation	differentiation	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	9	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	16	mark	_	_
7	cytokine	cytokine	NN	NN	_	11	compound	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	phorbol	phorbol	NN	NN	_	7	conj	_	_
10	ester	ester	NN	NN	_	11	compound	_	_
11	stimulation	stimulation	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	KG1	kg1	NN	NN	_	11	nmod	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	model	model	NN	NN	_	5	ccomp	_	_
17	of	of	IN	IN	_	23	case	_	_
18	human	human	JJ	JJ	_	20	amod	_	_
19	CD34+	cd34+	JJ	JJ	_	20	amod	_	_
20	HPC	hpc	NN	NN	_	23	compound	_	_
21	to	to	TO	TO	_	20	dep	_	_
22	DC	dc	NN	NN	_	20	dep	_	_
23	differentiation	differentiation	NN	NN	_	16	nmod	_	_
24	and	and	CC	CC	_	5	cc	_	_
25	suggest	suggest	VBP	VBP	_	5	conj	_	_
26	that	that	IN	IN	_	31	mark	_	_
27	specific	specific	JJ	JJ	_	30	amod	_	_
28	intracellular	intracellular	JJ	JJ	_	30	amod	_	_
29	signaling	signaling	NN	NN	_	30	compound	_	_
30	pathways	pathway	NNS	NNS	_	31	nsubj	_	_
31	mediate	mediate	VBP	VBP	_	25	ccomp	_	_
32	specific	specific	JJ	JJ	_	33	amod	_	_
33	events	event	NNS	NNS	_	31	dobj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	DC	dc	NN	NN	_	37	compound	_	_
36	lineage	lineage	NN	NN	_	37	compound	_	_
37	commitment	commitment	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	IL-2-mediated	il-2-mediated	JJ	JJ	_	4	amod	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	cycle	cycle	NN	NN	_	4	compound	_	_
4	progression	progression	NN	NN	_	11	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	inhibition	inhibition	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	require	require	VB	VB	_	0	root	_	_
12	NF-kappa	nf-kappa	NN	NN	_	13	compound	_	_
13	B	b	NN	NN	_	11	dobj	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	activating	activate	VBG	VBG	_	17	amod	_	_
16	protein-1	protein-1	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	conj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	primary	primary	JJ	JJ	_	22	amod	_	_
20	human	human	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	13	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	IL-2	il-2	NN	NN	_	4	compound	_	_
3	growth	growth	NN	NN	_	4	compound	_	_
4	hormone	hormone	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	the	the	DT	DT	_	9	det	_	_
7	major	major	JJ	JJ	_	9	amod	_	_
8	growth	growth	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	activated	activate	VBN	VBN	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
14	during	during	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	developing	develop	VBG	VBG	_	18	amod	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	9	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	IL-2	il-2	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	required	require	VBN	VBN	_	0	root	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	only	only	RB	RB	_	3	dep	_	_
6	for	for	IN	IN	_	9	case	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	cycle	cycle	NN	NN	_	9	compound	_	_
9	progression	progression	NN	NN	_	5	dep	_	_
10	but	but	CC	CC	_	5	cc	_	_
11	also	also	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	protect	protect	VB	VB	_	5	conj	_	_
14	Ag-activated	ag-activated	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	dobj	_	_
17	from	from	IN	IN	_	20	case	_	_
18	programmed	program	VBN	VBN	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	death	death	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	several	several	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	types	type	NNS	NNS	_	18	nmod	_	_
5	,	,	,	,	_	18	punct	_	_
6	activation	activation	NN	NN	_	18	nsubjpass	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	and/or	and/or	CC	CC	_	9	cc	_	_
11	activating	activate	VBG	VBG	_	12	amod	_	_
12	protein-1	protein-1	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	AP-1	ap-1	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
19	to	to	TO	TO	_	22	mark	_	_
20	be	be	VB	VB	_	22	cop	_	_
21	extremely	extremely	RB	RB	_	22	advmod	_	_
22	important	important	JJ	JJ	_	18	xcomp	_	_
23	in	in	IN	IN	_	24	mark	_	_
24	blocking	block	VBG	VBG	_	22	advcl	_	_
25	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
26	.	.	.	.	_	18	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	35	advcl	_	_
3	whether	whether	IN	IN	_	12	mark	_	_
4	either	either	DT	DT	_	12	nsubjpass	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	both	both	DT	DT	_	4	conj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	these	these	DT	DT	_	10	det	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	4	nmod	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	2	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	survival	survival	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	cycle	cycle	NN	NN	_	19	compound	_	_
19	progression	progression	NN	NN	_	15	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	response	response	NN	NN	_	23	dep	_	_
22	to	to	TO	TO	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	15	nmod	_	_
24	,	,	,	,	_	35	punct	_	_
25	primary	primary	JJ	JJ	_	28	amod	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	35	nsubjpass	_	_
29	responsive	responsive	JJ	JJ	_	28	amod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	growth	growth	NN	NN	_	33	compound	_	_
33	factor	factor	NN	NN	_	29	nmod	_	_
34	were	be	VBD	VBD	_	35	auxpass	_	_
35	analyzed	analyze	VBN	VBN	_	0	root	_	_
36	for	for	IN	IN	_	38	case	_	_
37	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
38	B	b	NN	NN	_	35	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	AP-1	ap-1	NN	NN	_	41	compound	_	_
41	activation	activation	NN	NN	_	38	conj	_	_
42	.	.	.	.	_	35	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	5	nsubj	_	_
4	clearly	clearly	RB	RB	_	5	advmod	_	_
5	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	IL-2	il-2	NN	NN	_	10	nsubj	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	induce	induce	VB	VB	_	5	ccomp	_	_
11	I	i	NN	NN	_	15	compound	_	_
12	kappa	kappa	NN	NN	_	15	compound	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	alpha	alpha	NN	NN	_	15	compound	_	_
15	degradation	degradation	NN	NN	_	10	dobj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	15	conj	_	_
20	in	in	IN	IN	_	24	case	_	_
21	primary	primary	JJ	JJ	_	24	amod	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	15	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	respond	respond	VBP	VBP	_	24	acl:relcl	_	_
27	to	to	TO	TO	_	28	case	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	by	by	IN	IN	_	30	mark	_	_
30	entering	enter	VBG	VBG	_	26	advcl	_	_
31	the	the	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	cycle	cycle	NN	NN	_	30	dobj	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	avoiding	avoid	VBG	VBG	_	30	conj	_	_
36	apoptosis	apoptosis	NN	NN	_	35	dobj	_	_
37	.	.	.	.	_	5	punct	_	_

1	Similarly	similarly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	IL-2	il-2	NN	NN	_	5	nsubj	_	_
4	neither	neither	CC	CC	_	5	cc:preconj	_	_
5	activates	activate	VBZ	VBZ	_	0	root	_	_
6	JNK	jnk	NN	NN	_	5	dobj	_	_
7	nor	nor	CC	CC	_	5	cc	_	_
8	increases	increase	VBZ	VBZ	_	5	conj	_	_
9	AP-1	ap-1	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	to	to	TO	TO	_	21	case	_	_
13	a	a	DT	DT	_	21	det	_	_
14	consensus	consensus	NN	NN	_	21	compound	_	_
15	o-tetradecanoylphorbol	o-tetradecanoylphorbol	NN	NN	_	21	compound	_	_
16	13-acetate	13-acetate	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	21	punct	_	_
18	TPA	tpa	NN	NN	_	21	compound	_	_
19	)	)	-RRB-	-RRB-	_	21	punct	_	_
20	response	response	NN	NN	_	21	compound	_	_
21	element	element	NN	NN	_	11	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	growth	growth	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	10	nsubj	_	_
9	does	do	VBZ	VBZ	_	10	aux	_	_
10	induce	induce	VB	VB	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activation	activation	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	STAT3	stat3	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	STAT5	stat5	NN	NN	_	14	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	cells	cell	NNS	NNS	_	12	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	as	as	IN	IN	_	25	mark	_	_
22	has	have	VBZ	VBZ	_	25	aux	_	_
23	been	be	VBN	VBN	_	25	auxpass	_	_
24	previously	previously	RB	RB	_	25	advmod	_	_
25	demonstrated	demonstrate	VBN	VBN	_	10	advcl	_	_
26	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	neither	neither	CC	CC	_	7	cc:preconj	_	_
6	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
7	B	b	NN	NN	_	12	nsubjpass	_	_
8	nor	nor	CC	CC	_	7	cc	_	_
9	AP-1	ap-1	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	conj	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	3	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	IL-2-mediated	il-2-mediated	JJ	JJ	_	15	amod	_	_
15	survival	survival	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	cell	cell	NN	NN	_	19	compound	_	_
18	cycle	cycle	NN	NN	_	19	compound	_	_
19	progression	progression	NN	NN	_	15	conj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	activated	activate	VBN	VBN	_	25	amod	_	_
22	primary	primary	JJ	JJ	_	25	amod	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	15	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Impaired	impaired	JJ	JJ	_	4	amod	_	_
2	fetal	fetal	JJ	JJ	_	4	amod	_	_
3	thymocyte	thymocyte	NN	NN	_	4	compound	_	_
4	development	development	NN	NN	_	0	root	_	_
5	after	after	IN	IN	_	8	case	_	_
6	efficient	efficient	JJ	JJ	_	8	amod	_	_
7	adenovirus-mediated	adenovirus-mediated	JJ	JJ	_	8	amod	_	_
8	inhibition	inhibition	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	introduce	introduce	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	6	det	_	_
4	new	new	JJ	JJ	_	6	amod	_	_
5	experimental	experimental	JJ	JJ	_	6	amod	_	_
6	system	system	NN	NN	_	2	dobj	_	_
7	combining	combine	VBG	VBG	_	6	acl	_	_
8	adenovirus-mediated	adenovirus-mediated	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transfer	transfer	NN	NN	_	7	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	fetal	fetal	JJ	JJ	_	15	amod	_	_
13	thymic	thymic	JJ	JJ	_	15	amod	_	_
14	organ	organ	NN	NN	_	15	compound	_	_
15	culture	culture	NN	NN	_	10	conj	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	FTOC	ftoc	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	system	system	NN	NN	_	3	nsubj	_	_
3	allowed	allow	VBD	VBD	_	0	root	_	_
4	us	we	PRP	PRP	_	7	nsubj	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	efficiently	efficiently	RB	RB	_	7	advmod	_	_
7	express	express	VB	VB	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	developing	develop	VBG	VBG	_	10	amod	_	_
10	thymocytes	thymocyte	NNS	NNS	_	7	nmod	_	_
11	a	a	DT	DT	_	13	det	_	_
12	mutant	mutant	JJ	JJ	_	13	amod	_	_
13	form	form	NN	NN	_	7	dobj	_	_
14	of	of	IN	IN	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
17	B	b	NN	NN	_	22	compound	_	_
18	inhibitor	inhibitor	NN	NN	_	22	compound	_	_
19	I	i	NN	NN	_	22	compound	_	_
20	kappa	kappa	NN	NN	_	22	compound	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	alpha	alpha	NN	NN	_	13	nmod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	mut-I	mut-i	NN	NN	_	26	compound	_	_
25	kappa	kappa	NN	NN	_	26	compound	_	_
26	B	b	NN	NN	_	13	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	7	cc	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	study	study	VB	VB	_	7	conj	_	_
31	the	the	DT	DT	_	33	det	_	_
32	maturation	maturation	NN	NN	_	33	compound	_	_
33	defects	defect	NNS	NNS	_	30	dobj	_	_
34	occurring	occur	VBG	VBG	_	33	acl	_	_
35	when	when	WRB	WRB	_	40	advmod	_	_
36	NF-kappa	nf-kappa	NN	NN	_	38	compound	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	activation	activation	NN	NN	_	40	nsubjpass	_	_
39	is	be	VBZ	VBZ	_	40	auxpass	_	_
40	inhibited	inhibit	VBN	VBN	_	34	advcl	_	_
41	during	during	IN	IN	_	43	case	_	_
42	fetal	fetal	JJ	JJ	_	43	amod	_	_
43	development	development	NN	NN	_	40	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	Fetal	fetal	JJ	JJ	_	2	amod	_	_
2	thymocytes	thymocyte	NNS	NNS	_	11	nsubjpass	_	_
3	infected	infect	VBN	VBN	_	2	acl	_	_
4	with	with	IN	IN	_	5	case	_	_
5	adenovirus	adenovirus	NN	NN	_	3	nmod	_	_
6	containing	contain	VBG	VBG	_	5	acl	_	_
7	mut-I	mut-i	NN	NN	_	9	compound	_	_
8	kappa	kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	dobj	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	develop	develop	VB	VB	_	11	xcomp	_	_
14	normally	normally	RB	RB	_	13	advmod	_	_
15	until	until	IN	IN	_	21	case	_	_
16	the	the	DT	DT	_	21	det	_	_
17	CD44-CD25+	cd44-cd25+	JJ	JJ	_	21	amod	_	_
18	,	,	,	,	_	17	punct	_	_
19	CD4-CD8-	cd4-cd8-	JJ	JJ	_	20	amod	_	_
20	double-negative	double-negative	JJ	JJ	_	17	dep	_	_
21	stage	stage	NN	NN	_	13	nmod	_	_
22	,	,	,	,	_	11	punct	_	_
23	while	while	IN	IN	_	34	mark	_	_
24	production	production	NN	NN	_	34	nsubjpass	_	_
25	of	of	IN	IN	_	31	case	_	_
26	more	more	RBR	RBR	_	27	advmod	_	_
27	mature	mature	JJ	JJ	_	31	amod	_	_
28	double-positive	double-positive	JJ	JJ	_	31	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	single-positive	single-positive	JJ	JJ	_	28	conj	_	_
31	populations	population	NNS	NNS	_	24	nmod	_	_
32	was	be	VBD	VBD	_	34	auxpass	_	_
33	strongly	strongly	RB	RB	_	34	advmod	_	_
34	decreased	decrease	VBN	VBN	_	11	advcl	_	_
35	.	.	.	.	_	11	punct	_	_

1	Proliferation	proliferation	NN	NN	_	12	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	as	as	IN	IN	_	4	mark	_	_
4	measured	measure	VBN	VBN	_	1	dep	_	_
5	by	by	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	percentage	percentage	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	cycle	cycle	NN	NN	_	9	nmod	_	_
12	appeared	appear	VBD	VBD	_	0	root	_	_
13	normal	normal	JJ	JJ	_	12	xcomp	_	_
14	,	,	,	,	_	12	punct	_	_
15	as	as	IN	IN	_	16	dep	_	_
16	did	do	VBD	VBD	_	12	advcl	_	_
17	rearrangement	rearrangement	NN	NN	_	16	nsubj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	expression	expression	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	TCR	tcr	NN	NN	_	23	compound	_	_
23	beta-chain	beta-chain	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	apoptosis	apoptosis	NN	NN	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	much	much	RB	RB	_	6	advmod	_	_
6	higher	higher	JJR	JJR	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	FTOC	ftoc	NN	NN	_	6	nmod	_	_
9	infected	infect	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	11	case	_	_
11	adenovirus	adenovirus	NN	NN	_	9	nmod	_	_
12	containing	contain	VBG	VBG	_	11	acl	_	_
13	mut-I	mut-i	NN	NN	_	15	compound	_	_
14	kappa	kappa	NN	NN	_	15	compound	_	_
15	B	b	NN	NN	_	12	dobj	_	_
16	than	than	IN	IN	_	18	case	_	_
17	in	in	IN	IN	_	18	case	_	_
18	FTOC	ftoc	NN	NN	_	6	advcl	_	_
19	infected	infect	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	control	control	JJ	JJ	_	23	amod	_	_
23	virus	virus	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	10	nsubj	_	_
10	plays	play	VBZ	VBZ	_	6	ccomp	_	_
11	a	a	DT	DT	_	13	det	_	_
12	crucial	crucial	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	15	mark	_	_
15	ensuring	ensure	VBG	VBG	_	10	advcl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	differentiation	differentiation	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	survival	survival	NN	NN	_	17	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	thymocytes	thymocyte	NNS	NNS	_	17	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	early	early	JJ	JJ	_	25	amod	_	_
25	stages	stage	NNS	NNS	_	17	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	their	they	PRP$	PRP$	_	28	nmod:poss	_	_
28	development	development	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	4E-BP1	4e-bp1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	4E-BP2	4e-bp2	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	repressors	repressor	NNS	NNS	_	4	appos	_	_
10	of	of	IN	IN	_	12	case	_	_
11	translation	translation	NN	NN	_	12	compound	_	_
12	initiation	initiation	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	during	during	IN	IN	_	18	case	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	differentiation	differentiation	NN	NN	_	2	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	myeloid	myeloid	JJ	JJ	_	3	amod	_	_
3	differentiation	differentiation	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	accompanied	accompany	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	decrease	decrease	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	proliferation	proliferation	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Because	because	IN	IN	_	8	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	translation	translation	NN	NN	_	4	compound	_	_
4	rate	rate	NN	NN	_	8	nsubj	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	determinant	determinant	NN	NN	_	15	advcl	_	_
9	of	of	IN	IN	_	11	case	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	proliferation	proliferation	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	we	we	PRP	PRP	_	15	nsubj	_	_
14	have	have	VBP	VBP	_	15	aux	_	_
15	investigated	investigate	VBN	VBN	_	0	root	_	_
16	translation	translation	NN	NN	_	17	compound	_	_
17	initiation	initiation	NN	NN	_	15	dobj	_	_
18	during	during	IN	IN	_	22	case	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	myeloid	myeloid	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	differentiation	differentiation	NN	NN	_	17	nmod	_	_
23	using	use	VBG	VBG	_	15	xcomp	_	_
24	the	the	DT	DT	_	29	det	_	_
25	HL-60	hl-60	NN	NN	_	29	compound	_	_
26	promyelocytic	promyelocytic	JJ	JJ	_	29	amod	_	_
27	leukemia	leukemia	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	line	line	NN	NN	_	23	dobj	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	the	the	DT	DT	_	35	det	_	_
32	U-937	u-937	NN	NN	_	35	compound	_	_
33	monoblastic	monoblastic	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	line	line	NN	NN	_	29	conj	_	_
36	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	translation	translation	NN	NN	_	6	compound	_	_
6	rate	rate	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	13	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	13	nsubjpass	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	8	advcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	differentiate	differentiate	VB	VB	_	13	xcomp	_	_
16	along	along	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	monocytic/macrophage	monocytic/macrophage	NN	NN	_	19	compound	_	_
19	pathway	pathway	NN	NN	_	15	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	along	along	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	granulocytic	granulocytic	JJ	JJ	_	24	amod	_	_
24	pathway	pathway	NN	NN	_	19	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	protein	protein	NN	NN	_	5	compound	_	_
5	synthesis	synthesis	NN	NN	_	2	nmod	_	_
6	correlates	correlate	VBZ	VBZ	_	0	root	_	_
7	with	with	IN	IN	_	9	case	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	two	two	CD	CD	_	12	nummod	_	_
12	repressors	repressor	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	translation	translation	NN	NN	_	15	compound	_	_
15	initiation	initiation	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	4E-BP1	4e-bp1	NN	NN	_	12	appos	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	4E-BP2	4e-bp2	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Induction	induction	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	HL-60	hl-60	NN	NN	_	7	compound	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	U-937	u-937	NN	NN	_	3	conj	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	1	nmod	_	_
8	into	into	IN	IN	_	9	case	_	_
9	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IFN-gamma	ifn-gamma	NN	NN	_	1	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	PMA	pma	NN	NN	_	11	conj	_	_
14	results	result	VBZ	VBZ	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	dephosphorylation	dephosphorylation	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	consequent	consequent	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	4E-BP1	4e-bp1	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Dephosphorylation	dephosphorylation	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	4E-BP1	4e-bp1	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	when	when	WRB	WRB	_	11	advmod	_	_
8	U-937	u-937	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	6	advcl	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	differentiate	differentiate	VB	VB	_	11	xcomp	_	_
14	into	into	IN	IN	_	15	case	_	_
15	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	13	nmod	_	_
16	following	follow	VBG	VBG	_	17	case	_	_
17	treatment	treatment	NN	NN	_	13	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	retinoic	retinoic	JJ	JJ	_	20	amod	_	_
20	acid	acid	NN	NN	_	17	nmod	_	_
21	or	or	CC	CC	_	20	cc	_	_
22	DMSO	dmso	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	24	nmod	_	_
3	,	,	,	,	_	24	punct	_	_
4	treatment	treatment	NN	NN	_	24	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	HL-60	hl-60	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	retinoic	retinoic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	4	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	DMSO	dmso	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	results	result	VBZ	VBZ	_	4	acl:relcl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	granulocytic	granulocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	these	these	DT	DT	_	22	det	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	4	punct	_	_
24	decreases	decrease	VBZ	VBZ	_	0	root	_	_
25	4E-BP1	4e-bp1	NN	NN	_	26	compound	_	_
26	amount	amount	NN	NN	_	24	dobj	_	_
27	without	without	IN	IN	_	28	mark	_	_
28	affecting	affect	VBG	VBG	_	24	advcl	_	_
29	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
30	phosphorylation	phosphorylation	NN	NN	_	28	dobj	_	_
31	and	and	CC	CC	_	24	cc	_	_
32	strongly	strongly	RB	RB	_	33	advmod	_	_
33	increases	increase	VBZ	VBZ	_	24	conj	_	_
34	4E-BP2	4e-bp2	NN	NN	_	35	compound	_	_
35	amount	amount	NN	NN	_	33	dobj	_	_
36	.	.	.	.	_	24	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	provide	provide	VBP	VBP	_	0	root	_	_
7	evidence	evidence	NN	NN	_	6	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	differential	differential	JJ	JJ	_	10	amod	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	translational	translational	JJ	JJ	_	14	amod	_	_
14	machinery	machinery	NN	NN	_	10	nmod	_	_
15	during	during	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	specific	specific	JJ	JJ	_	10	amod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	monocytic/macrophage	monocytic/macrophage	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	granulocytic	granulocytic	JJ	JJ	_	29	amod	_	_
29	pathway	pathway	NN	NN	_	24	conj	_	_
30	.	.	.	.	_	6	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	2	nsubj	_	_
2	promote	promote	VBP	VBP	_	0	root	_	_
3	nonphlogistic	nonphlogistic	JJ	JJ	_	4	amod	_	_
4	phagocytosis	phagocytosis	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	apoptotic	apoptotic	JJ	JJ	_	7	amod	_	_
7	leukocytes	leukocyte	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Phagocyte	phagocyte	NN	NN	_	2	compound	_	_
2	recognition	recognition	NN	NN	_	16	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	uptake	uptake	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	nonphlogistic	nonphlogistic	JJ	JJ	_	8	amod	_	_
8	degradation	degradation	NN	NN	_	2	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	neutrophils	neutrophil	NNS	NNS	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	other	other	JJ	JJ	_	13	amod	_	_
13	leukocytes	leukocyte	NNS	NNS	_	10	conj	_	_
14	undergoing	undergo	VBG	VBG	_	13	acl	_	_
15	apoptosis	apoptosis	NN	NN	_	14	dobj	_	_
16	promote	promote	VBP	VBP	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	resolution	resolution	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	inflammation	inflammation	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	assessed	assess	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	anti-inflammatory	anti-inflammatory	JJ	JJ	_	8	amod	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	13	case	_	_
10	this	this	DT	DT	_	13	det	_	_
11	leukocyte	leukocyte	NN	NN	_	13	compound	_	_
12	clearance	clearance	NN	NN	_	13	compound	_	_
13	mechanism	mechanism	NN	NN	_	5	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	36	nsubj	_	_
2	of	of	IN	IN	_	8	case	_	_
3	``	``	``	``	_	8	punct	_	_
4	semimature	semimature	JJ	JJ	_	8	amod	_	_
5	5-day	5-day	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	monocyte-derived	monocyte-derived	JJ	JJ	_	8	amod	_	_
8	macrophages	macrophage	NNS	NNS	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	M	m	NN	NN	_	11	compound	_	_
11	phi	phi	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	for	for	IN	IN	_	15	case	_	_
14	24	24	CD	CD	_	15	nummod	_	_
15	h	h	NN	NN	_	1	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	methylprednisolone	methylprednisolone	NN	NN	_	1	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	dexamethasone	dexamethasone	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	hydrocortisone	hydrocortisone	NN	NN	_	17	conj	_	_
23	,	,	,	,	_	17	punct	_	_
24	but	but	CC	CC	_	25	cc	_	_
25	not	not	RB	RB	_	17	cc	_	_
26	the	the	DT	DT	_	28	det	_	_
27	nonglucocorticoid	nonglucocorticoid	NN	NN	_	28	compound	_	_
28	steroids	steroid	NNS	NNS	_	17	conj	_	_
29	aldosterone	aldosterone	NN	NN	_	28	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	estradiol	estradiol	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	progesterone	progesterone	NN	NN	_	29	conj	_	_
35	,	,	,	,	_	17	punct	_	_
36	potentiated	potentiate	VBD	VBD	_	0	root	_	_
37	phagocytosis	phagocytosis	NN	NN	_	36	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	apoptotic	apoptotic	JJ	JJ	_	40	amod	_	_
40	neutrophils	neutrophil	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	36	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	specific	specific	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	15	mark	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	potentiated	potentiated	JJ	JJ	_	9	amod	_	_
9	phagocytosis	phagocytosis	NN	NN	_	15	nsubjpass	_	_
10	of	of	IN	IN	_	12	case	_	_
11	apoptotic	apoptotic	JJ	JJ	_	12	amod	_	_
12	neutrophils	neutrophil	NNS	NNS	_	9	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	completely	completely	RB	RB	_	15	advmod	_	_
15	blocked	block	VBN	VBN	_	4	advcl	_	_
16	by	by	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
19	receptor	receptor	NN	NN	_	21	compound	_	_
20	antagonist	antagonist	NN	NN	_	21	compound	_	_
21	RU38486	ru38486	NN	NN	_	15	nmod	_	_
22	,	,	,	,	_	4	punct	_	_
23	and	and	CC	CC	_	4	cc	_	_
24	glucocorticoids	glucocorticoid	NNS	NNS	_	27	nsubj	_	_
25	did	do	VBD	VBD	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	promote	promote	VB	VB	_	4	conj	_	_
28	5-day	5-day	JJ	JJ	_	31	amod	_	_
29	M	m	NN	NN	_	31	compound	_	_
30	phi	phi	NN	NN	_	31	compound	_	_
31	ingestion	ingestion	NN	NN	_	27	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	opsonized	opsonize	VBN	VBN	_	34	amod	_	_
34	erythrocytes	erythrocyte	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	Similar	similar	JJ	JJ	_	3	amod	_	_
2	glucocorticoid-mediated	glucocorticoid-mediated	JJ	JJ	_	3	amod	_	_
3	potentiation	potentiation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	5-day	5-day	JJ	JJ	_	10	amod	_	_
8	M	m	NN	NN	_	10	compound	_	_
9	phi	phi	NN	NN	_	10	compound	_	_
10	uptake	uptake	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	alternative	alternative	JJ	JJ	_	15	amod	_	_
13	apoptotic	apoptotic	JJ	JJ	_	15	amod	_	_
14	``	``	``	``	_	15	punct	_	_
15	targets	target	NNS	NNS	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	eosinophils	eosinophil	NNS	NNS	_	15	dep	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	Jurkat	jurkat	NN	NN	_	21	compound	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	conj	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	and	and	CC	CC	_	10	cc	_	_
24	in	in	IN	IN	_	25	case	_	_
25	uptake	uptake	NN	NN	_	10	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	apoptotic	apoptotic	JJ	JJ	_	28	amod	_	_
28	neutrophils	neutrophil	NNS	NNS	_	25	nmod	_	_
29	by	by	IN	IN	_	31	case	_	_
30	alternative	alternative	JJ	JJ	_	31	amod	_	_
31	phagocytes	phagocyte	NNS	NNS	_	25	nmod	_	_
32	(	(	-LRB-	-LRB-	_	36	punct	_	_
33	human	human	JJ	JJ	_	36	amod	_	_
34	glomerular	glomerular	JJ	JJ	_	36	amod	_	_
35	mesangial	mesangial	JJ	JJ	_	36	amod	_	_
36	cells	cell	NNS	NNS	_	31	dep	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	murine	murine	JJ	JJ	_	40	amod	_	_
39	M	m	NN	NN	_	40	compound	_	_
40	phi	phi	NN	NN	_	36	conj	_	_
41	elicited	elicit	VBN	VBN	_	36	dep	_	_
42	into	into	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	det	_	_
44	peritoneum	peritoneum	NN	NN	_	41	nmod	_	_
45	or	or	CC	CC	_	41	cc	_	_
46	derived	derive	VBN	VBN	_	41	conj	_	_
47	from	from	IN	IN	_	49	case	_	_
48	bone	bone	NN	NN	_	49	compound	_	_
49	marrow	marrow	NN	NN	_	46	nmod	_	_
50	)	)	-RRB-	-RRB-	_	36	punct	_	_
51	.	.	.	.	_	5	punct	_	_

1	Importantly	importantly	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	methylprednisolone-mediated	methylprednisolone-mediated	JJ	JJ	_	4	amod	_	_
4	enhancement	enhancement	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	uptake	uptake	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	apoptotic	apoptotic	JJ	JJ	_	10	amod	_	_
10	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	trigger	trigger	VB	VB	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	release	release	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	chemokines	chemokine	NNS	NNS	_	15	nmod	_	_
19	IL-8	il-8	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	monocyte	monocyte	NN	NN	_	23	compound	_	_
22	chemoattractant	chemoattractant	NN	NN	_	23	compound	_	_
23	protein-1	protein-1	NN	NN	_	19	conj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	longer-term	longer-term	JJ	JJ	_	4	amod	_	_
4	potentiation	potentiation	NN	NN	_	8	nsubjpass	_	_
5	by	by	IN	IN	_	6	case	_	_
6	methylprednisolone	methylprednisolone	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	maturing	mature	VBG	VBG	_	14	amod	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	monocyte-derived	monocyte-derived	JJ	JJ	_	14	amod	_	_
13	M	m	NN	NN	_	14	compound	_	_
14	phi	phi	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	with	with	IN	IN	_	28	mark	_	_
17	greater	greater	JJR	JJR	_	18	amod	_	_
18	increases	increase	NNS	NNS	_	28	nsubjpass	_	_
19	in	in	IN	IN	_	23	case	_	_
20	5-day	5-day	JJ	JJ	_	23	amod	_	_
21	M	m	NN	NN	_	23	compound	_	_
22	phi	phi	NN	NN	_	23	compound	_	_
23	uptake	uptake	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	apoptotic	apoptotic	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	being	be	VBG	VBG	_	28	auxpass	_	_
28	observed	observe	VBN	VBN	_	33	advcl	_	_
29	the	the	DT	DT	_	31	det	_	_
30	earlier	earlier	JJR	JJR	_	31	amod	_	_
31	glucocorticoids	glucocorticoid	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	added	add	VBN	VBN	_	8	parataxis	_	_
34	during	during	IN	IN	_	36	case	_	_
35	monocyte	monocyte	NN	NN	_	36	compound	_	_
36	maturation	maturation	NN	NN	_	33	nmod	_	_
37	into	into	IN	IN	_	39	case	_	_
38	M	m	NN	NN	_	39	compound	_	_
39	phi	phi	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	potentiation	potentiation	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	nonphlogistic	nonphlogistic	JJ	JJ	_	7	amod	_	_
7	clearance	clearance	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	apoptotic	apoptotic	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	phagocytes	phagocyte	NNS	NNS	_	4	nmod	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	a	a	DT	DT	_	17	det	_	_
15	hitherto	hitherto	RB	RB	_	16	advmod	_	_
16	unrecognized	unrecognized	JJ	JJ	_	17	amod	_	_
17	property	property	NN	NN	_	2	ccomp	_	_
18	of	of	IN	IN	_	19	case	_	_
19	glucocorticoids	glucocorticoid	NNS	NNS	_	17	nmod	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	has	have	VBZ	VBZ	_	17	acl:relcl	_	_
22	potential	potential	JJ	JJ	_	23	amod	_	_
23	implications	implication	NNS	NNS	_	21	dobj	_	_
24	for	for	IN	IN	_	25	case	_	_
25	therapies	therapy	NNS	NNS	_	23	nmod	_	_
26	aimed	aim	VBN	VBN	_	25	acl	_	_
27	at	at	IN	IN	_	28	mark	_	_
28	promoting	promote	VBG	VBG	_	26	advcl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	resolution	resolution	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	inflammatory	inflammatory	JJ	JJ	_	33	amod	_	_
33	diseases	disease	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD40	cd40	NN	NN	_	1	nmod	_	_
4	on	on	IN	IN	_	8	case	_	_
5	immunogenic	immunogenic	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	malignant	malignant	JJ	JJ	_	8	amod	_	_
8	melanomas	melanoma	NNS	NNS	_	1	nmod	_	_
9	augments	augment	VBZ	VBZ	_	0	root	_	_
10	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
11	cytotoxic	cytotoxic	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	nmod:npmod	_	_
13	lymphocyte-mediated	lymphocyte-mediated	JJ	JJ	_	14	amod	_	_
14	lysis	lysis	NN	NN	_	9	dobj	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	induces	induce	VBZ	VBZ	_	9	conj	_	_
17	apoptosis	apoptosis	NN	NN	_	16	dobj	_	_
18	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CD40	cd40	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	malignant	malignant	JJ	JJ	_	13	amod	_	_
13	melanomas	melanoma	NNS	NNS	_	7	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MMs	mm	NNS	NNS	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	4	punct	_	_

1	Comparison	comparison	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	tumor	tumor	NN	NN	_	4	compound	_	_
4	specimen	specimen	NN	NN	_	1	nmod	_	_
5	from	from	IN	IN	_	8	case	_	_
6	MM	mm	NN	NN	_	8	compound	_	_
7	precursor	precursor	NN	NN	_	8	compound	_	_
8	lesions	lesion	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	primary	primary	JJ	JJ	_	11	amod	_	_
11	tumors	tumor	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	metastases	metastase	NNS	NNS	_	8	conj	_	_
15	revealed	reveal	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	21	mark	_	_
17	CD40	cd40	NN	NN	_	19	compound	_	_
18	surface	surface	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	down-regulated	down-regulate	VBN	VBN	_	15	ccomp	_	_
22	during	during	IN	IN	_	24	case	_	_
23	tumor	tumor	NN	NN	_	24	compound	_	_
24	progression	progression	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	confirmed	confirm	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	7	7	CD	CD	_	10	nummod	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	MM	mm	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	lines	line	NNS	NNS	_	4	nmod	_	_
11	established	establish	VBN	VBN	_	10	acl	_	_
12	from	from	IN	IN	_	15	case	_	_
13	immunogenic	immunogenic	JJ	JJ	_	15	amod	_	_
14	primary	primary	JJ	JJ	_	15	amod	_	_
15	tumors	tumor	NNS	NNS	_	11	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	metastases	metastase	NNS	NNS	_	15	conj	_	_
18	,	,	,	,	_	4	punct	_	_
19	whereas	whereas	IN	IN	_	4	dep	_	_
20	11	11	CD	CD	_	22	nummod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	29	nsubj	_	_
23	established	establish	VBN	VBN	_	22	acl	_	_
24	from	from	IN	IN	_	26	case	_	_
25	advanced	advanced	JJ	JJ	_	26	amod	_	_
26	stages	stage	NNS	NNS	_	23	nmod	_	_
27	were	be	VBD	VBD	_	29	cop	_	_
28	CD40	cd40	NN	NN	_	29	nmod:npmod	_	_
29	negative	negative	JJ	JJ	_	4	parataxis	_	_
30	.	.	.	.	_	4	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	5	nsubjpass	_	_
3	could	could	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	enhanced	enhance	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	CD40-positive	cd40-positive	JJ	JJ	_	8	amod	_	_
8	MM	mm	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	5	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	IFN-gamma	ifn-gamma	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	tumor	tumor	NN	NN	_	16	compound	_	_
15	necrosis	necrosis	NN	NN	_	16	compound	_	_
16	factor-alpha	factor-alpha	NN	NN	_	12	conj	_	_
17	but	but	CC	CC	_	18	cc	_	_
18	not	not	RB	RB	_	10	cc	_	_
19	by	by	IN	IN	_	24	case	_	_
20	interleukin	interleukin	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	IL	il	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	-1beta	-1beta	NN	NN	_	10	conj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	CD40	cd40	NN	NN	_	27	compound	_	_
27	triggering	triggering	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	5	punct	_	_

1	CD40	cd40	NN	NN	_	2	compound	_	_
2	ligation	ligation	NN	NN	_	16	nsubj	_	_
3	on	on	IN	IN	_	4	case	_	_
4	MM	mm	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	CD40L-transfected	cd40l-transfected	JJ	JJ	_	8	amod	_	_
7	murine	murine	JJ	JJ	_	8	amod	_	_
8	L-cells	l-cell	NNS	NNS	_	2	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	by	by	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	soluble	soluble	JJ	JJ	_	15	amod	_	_
13	CD40L	cd40l	NN	NN	_	15	compound	_	_
14	fusion	fusion	NN	NN	_	15	compound	_	_
15	protein	protein	NN	NN	_	8	conj	_	_
16	up-regulated	up-regulate	VBD	VBD	_	0	root	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	intercellular	intercellular	JJ	JJ	_	22	amod	_	_
21	adhesion	adhesion	NN	NN	_	22	compound	_	_
22	molecule-1	molecule-1	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	MHC	mhc	NN	NN	_	25	compound	_	_
25	class	class	NN	NN	_	22	conj	_	_
26	I	i	CD	CD	_	25	nummod	_	_
27	and	and	CC	CC	_	25	cc	_	_
28	class	class	NN	NN	_	30	compound	_	_
29	II	ii	CD	CD	_	30	nummod	_	_
30	molecules	molecule	NNS	NNS	_	25	conj	_	_
31	and	and	CC	CC	_	18	cc	_	_
32	their	they	PRP$	PRP$	_	33	nmod:poss	_	_
33	secretion	secretion	NN	NN	_	18	conj	_	_
34	of	of	IN	IN	_	35	case	_	_
35	IL-6	il-6	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	IL-8	il-8	NN	NN	_	35	conj	_	_
38	,	,	,	,	_	35	punct	_	_
39	tumor	tumor	NN	NN	_	41	compound	_	_
40	necrosis	necrosis	NN	NN	_	41	compound	_	_
41	factor-a	factor-a	NN	NN	_	35	conj	_	_
42	,	,	,	,	_	35	punct	_	_
43	and	and	CC	CC	_	35	cc	_	_
44	granulocyte	granulocyte	NN	NN	_	47	compound	_	_
45	macrophage	macrophage	NN	NN	_	47	compound	_	_
46	colony-stimulating	colony-stimulating	JJ	JJ	_	47	amod	_	_
47	factor	factor	NN	NN	_	35	conj	_	_
48	and	and	CC	CC	_	16	cc	_	_
49	also	also	RB	RB	_	16	advmod	_	_
50	induced	induce	VBD	VBD	_	16	dep	_	_
51	a	a	DT	DT	_	53	det	_	_
52	rapid	rapid	JJ	JJ	_	53	amod	_	_
53	activation	activation	NN	NN	_	50	dobj	_	_
54	of	of	IN	IN	_	60	case	_	_
55	the	the	DT	DT	_	60	det	_	_
56	transcription	transcription	NN	NN	_	60	compound	_	_
57	factor	factor	NN	NN	_	60	compound	_	_
58	nuclear	nuclear	JJ	JJ	_	60	amod	_	_
59	factor	factor	NN	NN	_	60	compound	_	_
60	kappaB	kappab	NN	NN	_	53	nmod	_	_
61	.	.	.	.	_	16	punct	_	_

1	Furthermore	furthermore	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	CD40	cd40	NN	NN	_	4	compound	_	_
4	ligation	ligation	NN	NN	_	13	nsubj	_	_
5	of	of	IN	IN	_	12	case	_	_
6	a	a	DT	DT	_	12	det	_	_
7	HLA-A2+	hla-a2+	JJ	JJ	_	12	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	MelanA/MART1+	melana/mart1+	JJ	JJ	_	7	dep	_	_
10	MM	mm	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	line	line	NN	NN	_	4	nmod	_	_
13	enhanced	enhance	VBD	VBD	_	0	root	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	susceptibility	susceptibility	NN	NN	_	13	dobj	_	_
16	to	to	TO	TO	_	18	case	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	lysis	lysis	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	25	case	_	_
20	a	a	DT	DT	_	25	det	_	_
21	HLA-A2-restricted	hla-a2-restricted	JJ	JJ	_	25	amod	_	_
22	,	,	,	,	_	21	punct	_	_
23	MelanA/MART-1-specific	melana/mart-1-specific	JJ	JJ	_	21	dep	_	_
24	CTL	ctl	NN	NN	_	25	compound	_	_
25	clone	clone	NN	NN	_	13	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CD40	cd40	NN	NN	_	4	compound	_	_
4	ligation	ligation	NN	NN	_	5	nsubj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	growth	growth	NN	NN	_	7	compound	_	_
7	inhibition	inhibition	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	apoptosis	apoptosis	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	11	case	_	_
11	MM	mm	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	CD40-CD40L	cd40-cd40l	NN	NN	_	6	compound	_	_
6	interactions	interaction	NNS	NNS	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	play	play	VB	VB	_	3	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	augmenting	augment	VBG	VBG	_	8	advcl	_	_
14	antitumor	antitumor	NN	NN	_	15	compound	_	_
15	immunity	immunity	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	inducing	induce	VBG	VBG	_	13	conj	_	_
18	apoptosis	apoptosis	NN	NN	_	17	dobj	_	_
19	in	in	IN	IN	_	24	case	_	_
20	some	some	DT	DT	_	24	det	_	_
21	CD40-positive	cd40-positive	JJ	JJ	_	24	amod	_	_
22	immunogenic	immunogenic	JJ	JJ	_	24	amod	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	MMs	mm	NNS	NNS	_	17	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	death	death	NN	NN	_	4	nsubj	_	_
4	requires	require	VBZ	VBZ	_	0	root	_	_
5	autoinduction	autoinduction	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	leukemic	leukemic	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	5	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	contrast	contrast	NN	NN	_	6	dep	_	_
3	to	to	TO	TO	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	autoregulation	autoregulation	NN	NN	_	25	nmod	_	_
7	of	of	IN	IN	_	13	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GR	gr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	expression	expression	NN	NN	_	6	nmod	_	_
14	seen	see	VBN	VBN	_	6	acl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	most	most	JJS	JJS	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	tissues	tissue	NNS	NNS	_	17	conj	_	_
20	,	,	,	,	_	25	punct	_	_
21	GR	gr	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	25	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	25	auxpass	_	_
24	positively	positively	RB	RB	_	25	advmod	_	_
25	autoregulated	autoregulate	VBN	VBN	_	0	root	_	_
26	in	in	IN	IN	_	30	case	_	_
27	human	human	JJ	JJ	_	30	amod	_	_
28	leukemic	leukemic	JJ	JJ	_	30	amod	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	25	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	in	in	IN	IN	_	34	case	_	_
33	other	other	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	30	conj	_	_
35	sensitive	sensitive	JJ	JJ	_	34	amod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	39	amod	_	_
38	cell	cell	NN	NN	_	39	compound	_	_
39	death	death	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	25	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	28	advcl	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	positive	positive	JJ	JJ	_	5	amod	_	_
5	autoregulation	autoregulation	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	necessary	necessary	JJ	JJ	_	9	amod	_	_
9	component	component	NN	NN	_	2	ccomp	_	_
10	of	of	IN	IN	_	13	case	_	_
11	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	death	death	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	28	punct	_	_
15	a	a	DT	DT	_	18	det	_	_
16	wild-type	wild-type	JJ	JJ	_	18	amod	_	_
17	GR	gr	NN	NN	_	18	compound	_	_
18	gene	gene	NN	NN	_	28	nsubjpass	_	_
19	under	under	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	control	control	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	tetracycline-regulated	tetracycline-regulated	JJ	JJ	_	25	amod	_	_
25	promoter	promoter	NN	NN	_	21	nmod	_	_
26	was	be	VBD	VBD	_	28	auxpass	_	_
27	stably	stably	RB	RB	_	28	advmod	_	_
28	transfected	transfect	VBN	VBN	_	0	root	_	_
29	into	into	IN	IN	_	31	case	_	_
30	glucocorticoid-resistant	glucocorticoid-resistant	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	lacking	lack	VBG	VBG	_	31	acl	_	_
33	endogenous	endogenous	JJ	JJ	_	35	amod	_	_
34	functional	functional	JJ	JJ	_	35	amod	_	_
35	receptor	receptor	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	28	punct	_	_

1	Transfectants	transfectant	NNS	NNS	_	8	nsubj	_	_
2	grown	grow	VBN	VBN	_	1	acl	_	_
3	in	in	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	dep	_	_
5	presence	presence	NN	NN	_	7	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	tetracycline	tetracycline	NN	NN	_	2	nmod	_	_
8	contained	contain	VBD	VBD	_	0	root	_	_
9	about	about	RB	RB	_	10	advmod	_	_
10	15,000	15,000	CD	CD	_	11	nummod	_	_
11	receptors/cell	receptors/cell	NNS	NNS	_	8	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	a	a	DT	DT	_	14	det	_	_
14	value	value	NN	NN	_	11	appos	_	_
15	approximately	approximately	RB	RB	_	16	advmod	_	_
16	equal	equal	JJ	JJ	_	14	amod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	basal	basal	JJ	JJ	_	21	amod	_	_
19	level	level	NN	NN	_	21	compound	_	_
20	GR	gr	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	16	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	glucocorticoid-sensitive	glucocorticoid-sensitive	JJ	JJ	_	25	amod	_	_
24	6TG1.1	6tg1.1	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	21	nmod	_	_
26	before	before	IN	IN	_	28	case	_	_
27	steroid	steroid	NN	NN	_	28	compound	_	_
28	treatment	treatment	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	dexamethasone	dexamethasone	NN	NN	_	6	nsubj	_	_
6	had	have	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	minimal	minimal	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	on	on	IN	IN	_	12	case	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	growth	growth	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	elicited	elicit	VBD	VBD	_	6	conj	_	_
15	little	little	JJ	JJ	_	18	amod	_	_
16	internucleosomal	internucleosomal	JJ	JJ	_	18	amod	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	fragmentation	fragmentation	NN	NN	_	14	dobj	_	_
19	,	,	,	,	_	6	punct	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	induced	induce	VBD	VBD	_	6	conj	_	_
22	no	no	DT	DT	_	25	neg	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	cycle	cycle	NN	NN	_	25	compound	_	_
25	perturbation	perturbation	NN	NN	_	21	dobj	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	dep	_	_
3	absence	absence	NN	NN	_	5	dep	_	_
4	of	of	IN	IN	_	5	case	_	_
5	tetracycline	tetracycline	NN	NN	_	12	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	GR	gr	NN	NN	_	8	compound	_	_
8	mRNA	mrna	NN	NN	_	12	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	8	conj	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	2-3-fold	2-3-fold	RB	RB	_	12	advmod	_	_
14	,	,	,	,	_	12	punct	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	cells	cell	NNS	NNS	_	17	nsubj	_	_
17	expressed	express	VBD	VBD	_	12	conj	_	_
18	48,000	48,000	CD	CD	_	19	nummod	_	_
19	receptors	receptor	NNS	NNS	_	17	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	a	a	DT	DT	_	22	det	_	_
22	level	level	NN	NN	_	19	appos	_	_
23	nearly	nearly	RB	RB	_	24	advmod	_	_
24	equivalent	equivalent	JJ	JJ	_	22	amod	_	_
25	to	to	TO	TO	_	26	case	_	_
26	that	that	DT	DT	_	24	nmod	_	_
27	present	present	JJ	JJ	_	26	amod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	6TG1.1	6tg1.1	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	after	after	IN	IN	_	33	case	_	_
32	18	18	CD	CD	_	33	nummod	_	_
33	h	h	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	autoinduction	autoinduction	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	12	punct	_	_

1	Under	under	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	conditions	condition	NNS	NNS	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	dexamethasone	dexamethasone	NN	NN	_	7	nsubj	_	_
6	markedly	markedly	RB	RB	_	7	advmod	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	growth	growth	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	7	punct	_	_
11	caused	cause	VBD	VBD	_	7	conj	_	_
12	G1	g1	NN	NN	_	13	compound	_	_
13	arrest	arrest	NN	NN	_	11	dobj	_	_
14	,	,	,	,	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	induced	induce	VBD	VBD	_	7	conj	_	_
17	significant	significant	JJ	JJ	_	20	amod	_	_
18	internucleosomal	internucleosomal	JJ	JJ	_	20	amod	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	fragmentation	fragmentation	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	basal	basal	JJ	JJ	_	9	amod	_	_
7	level	level	NN	NN	_	9	compound	_	_
8	GR	gr	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	inadequate	inadequate	JJ	JJ	_	4	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	mediate	mediate	VB	VB	_	11	xcomp	_	_
14	glucocorticoid-induced	glucocorticoid-induced	JJ	JJ	_	15	amod	_	_
15	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	glucocorticoid-sensitive	glucocorticoid-sensitive	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	that	that	IN	IN	_	27	mark	_	_
22	positive	positive	JJ	JJ	_	23	amod	_	_
23	autoregulation	autoregulation	NN	NN	_	27	nsubj	_	_
24	is	be	VBZ	VBZ	_	27	cop	_	_
25	a	a	DT	DT	_	27	det	_	_
26	necessary	necessary	JJ	JJ	_	27	amod	_	_
27	component	component	NN	NN	_	11	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	this	this	DT	DT	_	30	det	_	_
30	process	process	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Jeg-3	jeg-3	NN	NN	_	3	nmod:npmod	_	_
2	human	human	JJ	JJ	_	3	amod	_	_
3	choriocarcinoma-induced	choriocarcinoma-induced	JJ	JJ	_	4	amod	_	_
4	immunosuppression	immunosuppression	NN	NN	_	0	root	_	_
5	:	:	:	:	_	4	punct	_	_
6	downregulation	downregulation	NN	NN	_	4	dep	_	_
7	of	of	IN	IN	_	8	case	_	_
8	interleukin-2	interleukin-2	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	interleukin-2	interleukin-2	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	alpha-chain	alpha-chain	NN	NN	_	6	conj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
16	Jak/Stat	jak/stat	NN	NN	_	18	compound	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	6	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	PROBLEM	problem	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	25	nsubjpass	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	immunosuppressive	immunosuppressive	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immunosuppression-inducing	immunosuppression-inducing	JJ	JJ	_	7	conj	_	_
10	capacities	capacity	NNS	NNS	_	4	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	Jeg-3	jeg-3	NN	NN	_	17	compound	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	choriocarcinoma	choriocarcinoma	NN	NN	_	17	compound	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	line	line	NN	NN	_	17	compound	_	_
17	supernatants	supernatant	NNS	NNS	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HCSs	hcss	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	are	be	VBP	VBP	_	25	auxpass	_	_
22	not	not	RB	RB	_	25	neg	_	_
23	yet	yet	RB	RB	_	25	advmod	_	_
24	completely	completely	RB	RB	_	25	advmod	_	_
25	understood	understand	VBN	VBN	_	1	appos	_	_
26	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	influence	influence	NN	NN	_	62	nsubjpass	_	_
3	on	on	IN	IN	_	17	case	_	_
4	interleukin	interleukin	NN	NN	_	17	compound	_	_
5	(	(	-LRB-	-LRB-	_	17	punct	_	_
6	IL	il	NN	NN	_	17	compound	_	_
7	)	)	-RRB-	-RRB-	_	17	punct	_	_
8	-2	-2	CD	CD	_	17	compound	_	_
9	,	,	,	,	_	8	punct	_	_
10	IL-4	il-4	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	interferon	interferon	NN	NN	_	8	conj	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	IFN	ifn	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	-gamma	-gamma	NN	NN	_	17	compound	_	_
17	production	production	NN	NN	_	2	nmod	_	_
18	;	;	:	:	_	17	punct	_	_
19	IL-2	il-2	NN	NN	_	22	compound	_	_
20	receptor	receptor	NN	NN	_	22	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IL-2R	il-2r	NN	NN	_	17	conj	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	alpha-	alpha-	NN	NN	_	22	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	beta-	beta-	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	gamma-chain	gamma-chain	NN	NN	_	24	conj	_	_
30	;	;	:	:	_	17	punct	_	_
31	and	and	CC	CC	_	17	cc	_	_
32	the	the	DT	DT	_	35	det	_	_
33	signaling	signaling	NN	NN	_	35	compound	_	_
34	pathway	pathway	NN	NN	_	35	compound	_	_
35	molecules	molecule	NNS	NNS	_	17	conj	_	_
36	Janus	janus	NN	NN	_	37	compound	_	_
37	kinase	kinase	NN	NN	_	35	dep	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	Jak	jak	NN	NN	_	37	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	1	1	CD	CD	_	39	nummod	_	_
42	,	,	,	,	_	39	punct	_	_
43	Jak3	jak3	NN	NN	_	39	appos	_	_
44	,	,	,	,	_	37	punct	_	_
45	signal	signal	NN	NN	_	46	compound	_	_
46	transducers	transducer	NNS	NNS	_	37	appos	_	_
47	and	and	CC	CC	_	46	cc	_	_
48	activators	activator	NNS	NNS	_	50	compound	_	_
49	of	of	IN	IN	_	50	amod	_	_
50	transcription	transcription	NN	NN	_	46	conj	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	Stat	stat	NN	NN	_	46	dep	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	1	1	CD	CD	_	52	nummod	_	_
55	,	,	,	,	_	52	punct	_	_
56	Stat3	stat3	NN	NN	_	52	conj	_	_
57	,	,	,	,	_	52	punct	_	_
58	and	and	CC	CC	_	52	cc	_	_
59	Stat5	stat5	NN	NN	_	52	conj	_	_
60	should	should	MD	MD	_	62	aux	_	_
61	be	be	VB	VB	_	62	auxpass	_	_
62	investigated	investigate	VBN	VBN	_	0	root	_	_
63	.	.	.	.	_	62	punct	_	_

1	METHOD	method	NN	NN	_	0	root	_	_
2	OF	of	IN	IN	_	3	case	_	_
3	STUDY	study	NN	NN	_	1	nmod	_	_
4	:	:	:	:	_	1	punct	_	_
5	For	for	IN	IN	_	6	case	_	_
6	assessment	assessment	NN	NN	_	19	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	IL	il	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	19	punct	_	_
11	whole	whole	JJ	JJ	_	14	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	venous	venous	JJ	JJ	_	14	amod	_	_
14	blood	blood	NN	NN	_	19	nsubjpass	_	_
15	from	from	IN	IN	_	17	case	_	_
16	healthy	healthy	JJ	JJ	_	17	amod	_	_
17	donors	donor	NNS	NNS	_	14	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	stimulated	stimulate	VBN	VBN	_	1	dep	_	_
20	with	with	IN	IN	_	21	case	_	_
21	phorbol-myristate-acetate	phorbol-myristate-acetate	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	ionomycine	ionomycine	NN	NN	_	21	conj	_	_
24	.	.	.	.	_	1	punct	_	_

1	Secretion	secretion	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ILs	il	NNS	NNS	_	1	nmod	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	blocked	block	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	monensine	monensine	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	Intracellular	intracellular	JJ	JJ	_	2	amod	_	_
2	ILs	il	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	analyzed	analyze	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	flow	flow	NN	NN	_	7	compound	_	_
7	cytometry	cytometry	NN	NN	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	For	for	IN	IN	_	7	case	_	_
2	IL-2R	il-2r	NN	NN	_	7	compound	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	signaling	signaling	NN	NN	_	2	conj	_	_
5	pathway	pathway	NN	NN	_	7	compound	_	_
6	molecule	molecule	NN	NN	_	7	compound	_	_
7	analysis	analysis	NN	NN	_	13	nmod	_	_
8	,	,	,	,	_	13	punct	_	_
9	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
10	blood	blood	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	13	nsubjpass	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	stimulated	stimulate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	15	case	_	_
15	phytohemagglutinin	phytohemagglutinin	NN	NN	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	PHA	pha	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	13	punct	_	_

1	IL-2R	il-2r	NN	NN	_	2	compound	_	_
2	chains	chain	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	measured	measure	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	flow	flow	NN	NN	_	7	compound	_	_
7	cytometry	cytometry	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	Jaks/Stats	jaks/stats	NN	NN	_	4	conj	_	_
11	by	by	IN	IN	_	17	case	_	_
12	sodium	sodium	NN	NN	_	17	compound	_	_
13	dodecyl	dodecyl	NN	NN	_	17	compound	_	_
14	sulfate	sulfate	NN	NN	_	17	compound	_	_
15	polyacrylamide	polyacrylamide	NN	NN	_	17	compound	_	_
16	gel	gel	NN	NN	_	17	compound	_	_
17	electrophoresis	electrophoresis	NN	NN	_	10	dep	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SDS-PAGE	sds-page	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	Western	western	NN	NN	_	23	compound	_	_
23	blot	blot	NN	NN	_	17	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Phorbol-myristate-acetate	phorbol-myristate-acetate	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	ionomycine	ionomycine	NN	NN	_	3	conj	_	_
6	strongly	strongly	RB	RB	_	7	advmod	_	_
7	increase	increase	VBP	VBP	_	1	appos	_	_
8	the	the	DT	DT	_	9	det	_	_
9	percent-age	percent-age	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-2+	il-2+	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	;	;	:	:	_	1	punct	_	_
14	an	a	DT	DT	_	18	det	_	_
15	additional	additional	JJ	JJ	_	18	amod	_	_
16	50	50	CD	CD	_	17	compound	_	_
17	%	%	NN	NN	_	18	amod	_	_
18	HCSs	hcss	NNS	NNS	_	20	nsubj	_	_
19	significantly	significantly	RB	RB	_	20	advmod	_	_
20	suppresses	suppress	VBZ	VBZ	_	1	dep	_	_
21	the	the	DT	DT	_	22	det	_	_
22	percentage	percentage	NN	NN	_	20	dobj	_	_
23	to	to	TO	TO	_	28	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	or	or	CC	CC	_	23	cc	_	_
26	below	below	IN	IN	_	23	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	level	level	NN	NN	_	20	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	unstimulated	unstimulated	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	IFN-gamma	ifn-gamma	NN	NN	_	2	compound	_	_
2	production	production	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	strongly	strongly	RB	RB	_	5	advmod	_	_
5	decreased	decrease	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	HCSs	hcss	NNS	NNS	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	some	some	DT	DT	_	10	det	_	_
10	cases	case	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	13	cc	_	_
13	not	not	RB	RB	_	10	cc	_	_
14	in	in	IN	IN	_	15	case	_	_
15	others	other	NNS	NNS	_	10	conj	_	_
16	.	.	.	.	_	5	punct	_	_

1	PHA	pha	NN	NN	_	2	nsubj	_	_
2	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
3	IL-2R	il-2r	NN	NN	_	6	compound	_	_
4	alpha-	alpha-	NN	NN	_	6	compound	_	_
5	,	,	,	,	_	6	punct	_	_
6	beta-	beta-	NN	NN	_	2	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	gamma-chain	gamma-chain	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	conj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
13	signaling	signaling	NN	NN	_	15	compound	_	_
14	pathway	pathway	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	6	conj	_	_
16	Jak1	jak1	NN	NN	_	15	dep	_	_
17	,	,	,	,	_	16	punct	_	_
18	Jak3	jak3	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	Stat1	stat1	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	Stat3	stat3	NN	NN	_	16	conj	_	_
23	,	,	,	,	_	16	punct	_	_
24	and	and	CC	CC	_	16	cc	_	_
25	Stat5	stat5	NN	NN	_	16	conj	_	_
26	.	.	.	.	_	2	punct	_	_

1	50	50	CD	CD	_	2	compound	_	_
2	%	%	NN	NN	_	3	amod	_	_
3	HCS	hcs	NN	NN	_	4	nsubj	_	_
4	downregulates	downregulate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	alpha-chain	alpha-chain	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	slightly	slightly	RB	RB	_	9	advmod	_	_
9	upregulates	upregulate	VBZ	VBZ	_	4	conj	_	_
10	the	the	DT	DT	_	11	det	_	_
11	beta-chain	beta-chain	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	4	punct	_	_

1	Jak1	jak1	NN	NN	_	7	compound	_	_
2	,	,	,	,	_	7	punct	_	_
3	Jak3	jak3	NN	NN	_	7	dep	_	_
4	,	,	,	,	_	7	punct	_	_
5	Stat1	stat1	NN	NN	_	7	dep	_	_
6	,	,	,	,	_	7	punct	_	_
7	Stat3	stat3	NN	NN	_	13	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	Stat5	stat5	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	suppressed	suppress	VBN	VBN	_	0	root	_	_
14	approximately	approximately	RB	RB	_	20	advmod	_	_
15	to	to	TO	TO	_	20	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	or	or	CC	CC	_	15	cc	_	_
18	below	below	IN	IN	_	15	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	level	level	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	unstimulated	unstimulated	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	13	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	HCS	hcs	NN	NN	_	5	nsubj	_	_
4	forcefully	forcefully	RB	RB	_	5	advmod	_	_
5	blocks	block	VBZ	VBZ	_	1	appos	_	_
6	the	the	DT	DT	_	7	det	_	_
7	production	production	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IL-2	il-2	NN	NN	_	7	nmod	_	_
10	;	;	:	:	_	7	punct	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-2R	il-2r	NN	NN	_	13	compound	_	_
13	alpha-chain	alpha-chain	NN	NN	_	7	conj	_	_
14	;	;	:	:	_	7	punct	_	_
15	and	and	CC	CC	_	7	cc	_	_
16	Jak1	jak1	NN	NN	_	22	compound	_	_
17	,	,	,	,	_	22	punct	_	_
18	Jak3	jak3	NN	NN	_	22	dep	_	_
19	,	,	,	,	_	22	punct	_	_
20	Stat1	stat1	NN	NN	_	22	dep	_	_
21	,	,	,	,	_	22	punct	_	_
22	Stat3	stat3	NN	NN	_	7	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	and	and	CC	CC	_	22	cc	_	_
25	Stat5	stat5	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	observed	observe	VBN	VBN	_	3	amod	_	_
3	phenomena	phenomenon	NNS	NNS	_	6	nsubjpass	_	_
4	might	might	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	caused	cause	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	downregulation	downregulation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	an	a	DT	DT	_	13	det	_	_
11	IL-2R	il-2r	NN	NN	_	13	compound	_	_
12	regulation	regulation	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	might	might	MD	MD	_	17	aux	_	_
17	play	play	VB	VB	_	6	conj	_	_
18	a	a	DT	DT	_	20	det	_	_
19	key	key	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expansion	expansion	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	choriocarcinoma	choriocarcinoma	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	possibly	possibly	RB	RB	_	31	advmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	survival	survival	NN	NN	_	23	conj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	fetal	fetal	JJ	JJ	_	35	amod	_	_
35	allograft	allograft	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	Characterization	characterization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	expression	expression	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	gene	gene	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	14	case	_	_
8	human	human	JJ	JJ	_	14	amod	_	_
9	pterin	pterin	NN	NN	_	14	compound	_	_
10	carbinolamine	carbinolamine	NN	NN	_	14	compound	_	_
11	dehydratase/dimerization	dehydratase/dimerization	NN	NN	_	14	compound	_	_
12	cofactor	cofactor	NN	NN	_	14	compound	_	_
13	of	of	IN	IN	_	14	amod	_	_
14	HNF1	hnf1	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Pterin	pterin	NN	NN	_	6	compound	_	_
2	carbinolamine	carbinolamine	NN	NN	_	6	compound	_	_
3	dehydratase/dimerization	dehydratase/dimerization	NN	NN	_	6	compound	_	_
4	cofactor	cofactor	NN	NN	_	6	compound	_	_
5	of	of	IN	IN	_	6	amod	_	_
6	HNF1	hnf1	NN	NN	_	13	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PCD/DCoH	pcd/dcoh	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	a	a	DT	DT	_	13	det	_	_
12	dual-function	dual-function	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	cytoplasm	cytoplasm	NN	NN	_	5	nmod	_	_
4	it	it	PRP	PRP	_	5	nsubj	_	_
5	acts	act	VBZ	VBZ	_	0	root	_	_
6	as	as	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	dehydratase	dehydratase	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	regeneration	regeneration	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	tetrahydrobiopterin	tetrahydrobiopterin	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cofactor	cofactor	NN	NN	_	13	appos	_	_
17	for	for	IN	IN	_	21	case	_	_
18	aromatic	aromatic	JJ	JJ	_	21	amod	_	_
19	amino	amino	NN	NN	_	21	compound	_	_
20	acid	acid	NN	NN	_	21	compound	_	_
21	hydroxylases	hydroxylase	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	nucleus	nucleus	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	it	it	PRP	PRP	_	6	nsubj	_	_
6	functions	function	VBZ	VBZ	_	0	root	_	_
7	as	as	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dimerization	dimerization	NN	NN	_	10	compound	_	_
10	cofactor	cofactor	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HNF1	hnf1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	increases	increase	VBZ	VBZ	_	6	conj	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HNF1	hnf1	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	deepen	deepen	VB	VB	_	10	advcl	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	understanding	understanding	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	protein	protein	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	characterized	characterize	VBD	VBD	_	0	root	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	expression	expression	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	tissues	tissue	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cells	cell	NNS	NNS	_	15	conj	_	_
18	.	.	.	.	_	10	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	PCD/DCoH	pcd/dcoh	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	predominantly	predominantly	RB	RB	_	4	advcl	_	_
6	in	in	IN	IN	_	7	case	_	_
7	liver	liver	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	kidney	kidney	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	with	with	IN	IN	_	13	case	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	amounts	amount	NNS	NNS	_	5	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	testis	testis	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	ovary	ovary	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	trace	trace	NN	NN	_	20	compound	_	_
20	amounts	amount	NNS	NNS	_	13	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	lung	lung	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	and	and	CC	CC	_	13	cc	_	_
25	undetectable	undetectable	JJ	JJ	_	26	amod	_	_
26	levels	level	NNS	NNS	_	13	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	whole	whole	JJ	JJ	_	29	amod	_	_
29	brain	brain	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	heart	heart	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	and	and	CC	CC	_	29	cc	_	_
34	spleen	spleen	NN	NN	_	29	conj	_	_
35	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	expressed	express	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	5	case	_	_
5	all	all	DT	DT	_	3	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	that	that	WDT	WDT	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	examined	examine	VBN	VBN	_	8	acl:relcl	_	_
12	.	.	.	.	_	3	punct	_	_

1	Importantly	importantly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	it	it	PRP	PRP	_	6	nsubj	_	_
4	was	be	VBD	VBD	_	6	cop	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	HeLa	hela	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	lack	lack	VBP	VBP	_	12	acl:relcl	_	_
16	HNF1	hnf1	NN	NN	_	15	dobj	_	_
17	,	,	,	,	_	9	punct	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	cytoplasm	cytoplasm	NN	NN	_	9	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	fibroblasts	fibroblast	NNS	NNS	_	21	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	have	have	VBP	VBP	_	23	acl:relcl	_	_
26	little	little	JJ	JJ	_	29	amod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	no	no	DT	DT	_	26	conj	_	_
29	tetrahydrobiopterin	tetrahydrobiopterin	NN	NN	_	25	dobj	_	_
30	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	PCD/DCoH	pcd/dcoh	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	liver	liver	NN	NN	_	2	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	nonhepatic	nonhepatic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	compared	compare	VBN	VBN	_	0	root	_	_
14	at	at	IN	IN	_	20	case	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	mRNA	mrna	NN	NN	_	20	compound	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	protein	protein	NN	NN	_	17	conj	_	_
20	levels	level	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Although	although	IN	IN	_	10	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	mRNA	mrna	NN	NN	_	4	compound	_	_
4	level	level	NN	NN	_	10	nsubj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	liver	liver	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	10	cop	_	_
8	only	only	RB	RB	_	10	advmod	_	_
9	fourfold	fourfold	RB	RB	_	10	advmod	_	_
10	higher	higher	JJR	JJR	_	25	advcl	_	_
11	than	than	IN	IN	_	12	case	_	_
12	that	that	DT	DT	_	10	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	keratinocytes	keratinocyte	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	fibroblasts	fibroblast	NNS	NNS	_	14	conj	_	_
17	,	,	,	,	_	25	punct	_	_
18	the	the	DT	DT	_	22	det	_	_
19	hepatic	hepatic	JJ	JJ	_	22	amod	_	_
20	PCD/DCoH	pcd/dcoh	NN	NN	_	22	compound	_	_
21	protein	protein	NN	NN	_	22	compound	_	_
22	level	level	NN	NN	_	25	nsubj	_	_
23	was	be	VBD	VBD	_	25	cop	_	_
24	20-fold	20-fold	RB	RB	_	25	advmod	_	_
25	higher	higher	JJR	JJR	_	0	root	_	_
26	than	than	IN	IN	_	27	case	_	_
27	that	that	DT	DT	_	25	nmod	_	_
28	in	in	IN	IN	_	32	case	_	_
29	normal	normal	JJ	JJ	_	32	amod	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	epidermal	epidermal	JJ	JJ	_	32	amod	_	_
32	keratinocytes	keratinocyte	NNS	NNS	_	27	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	dermal	dermal	JJ	JJ	_	35	amod	_	_
35	fibroblasts	fibroblast	NNS	NNS	_	32	conj	_	_
36	.	.	.	.	_	25	punct	_	_

1	Cloning	cloning	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	5'	5'	JJ	JJ	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	3'	3'	JJ	JJ	_	8	amod	_	_
7	untranslated	untranslated	JJ	JJ	_	8	amod	_	_
8	region	region	NN	NN	_	4	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	UTR	utr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	of	of	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	keratinocyte	keratinocyte	NN	NN	_	15	compound	_	_
15	PCD/DCoH	pcd/dcoh	NN	NN	_	4	nmod	_	_
16	revealed	reveal	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	19	mark	_	_
18	it	it	PRP	PRP	_	19	nsubj	_	_
19	has	have	VBZ	VBZ	_	16	ccomp	_	_
20	53	53	CD	CD	_	22	nummod	_	_
21	bp	bp	NN	NN	_	22	dep	_	_
22	more	more	JJR	JJR	_	19	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	GC-rich	gc-rich	JJ	JJ	_	27	amod	_	_
25	5'	5'	JJ	JJ	_	27	amod	_	_
26	untranslated	untranslated	JJ	JJ	_	27	amod	_	_
27	sequence	sequence	NN	NN	_	22	nmod	_	_
28	than	than	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	published	publish	VBN	VBN	_	32	amod	_	_
31	liver	liver	NN	NN	_	32	compound	_	_
32	PCD/DCoH	pcd/dcoh	NN	NN	_	19	nmod	_	_
33	.	.	.	.	_	16	punct	_	_

1	In	in	FW	FW	_	3	compound	_	_
2	vitro	vitro	FW	FW	_	3	compound	_	_
3	transcription	transcription	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	translation	translation	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	3	conj	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	13	mark	_	_
9	the	the	DT	DT	_	12	det	_	_
10	longer	longer	JJR	JJR	_	12	amod	_	_
11	5'	5'	JJ	JJ	_	12	amod	_	_
12	UTR	utr	NN	NN	_	13	nsubj	_	_
13	resulted	result	VBD	VBD	_	7	ccomp	_	_
14	in	in	IN	IN	_	19	case	_	_
15	about	about	RB	RB	_	17	advmod	_	_
16	a	a	DT	DT	_	17	advmod	_	_
17	35	35	CD	CD	_	19	nummod	_	_
18	%	%	NN	NN	_	19	compound	_	_
19	decrease	decrease	NN	NN	_	13	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	translation	translation	NN	NN	_	22	compound	_	_
22	efficiency	efficiency	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	PCD/DCoH	pcd/dcoh	NN	NN	_	7	nsubj	_	_
7	is	be	VBZ	VBZ	_	3	ccomp	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	only	only	RB	RB	_	7	dep	_	_
10	present	present	JJ	JJ	_	7	conj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	where	where	WRB	WRB	_	16	advmod	_	_
14	tetrahydrobiopterin	tetrahydrobiopterin	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	synthesized	synthesize	VBN	VBN	_	12	acl:relcl	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	HNF1	hnf1	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	present	present	JJ	JJ	_	16	conj	_	_
21	but	but	CC	CC	_	7	cc	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	a	a	DT	DT	_	26	det	_	_
24	widely	widely	RB	RB	_	26	advmod	_	_
25	distributed	distribute	VBN	VBN	_	26	amod	_	_
26	protein	protein	NN	NN	_	7	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Its	its	PRP$	PRP$	_	3	nmod:poss	_	_
2	differential	differential	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	10	nsubjpass	_	_
4	in	in	IN	IN	_	6	case	_	_
5	different	different	JJ	JJ	_	6	amod	_	_
6	tissues	tissue	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	cells	cell	NNS	NNS	_	6	conj	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	regulated	regulate	VBN	VBN	_	0	root	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	only	only	RB	RB	_	16	cc:preconj	_	_
13	at	at	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	level	level	NN	NN	_	10	nmod	_	_
17	but	but	CC	CC	_	16	cc	_	_
18	also	also	RB	RB	_	22	advmod	_	_
19	at	at	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	translational	translational	JJ	JJ	_	22	amod	_	_
22	level	level	NN	NN	_	16	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	Essential	essential	JJ	JJ	_	2	amod	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	alveolar	alveolar	JJ	JJ	_	5	amod	_	_
5	macrophages	macrophage	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	intrapulmonary	intrapulmonary	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Acute	acute	JJ	JJ	_	3	amod	_	_
2	inflammatory	inflammatory	JJ	JJ	_	3	amod	_	_
3	injury	injury	NN	NN	_	15	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	rat	rat	NN	NN	_	6	compound	_	_
6	lung	lung	NN	NN	_	3	nmod	_	_
7	induced	induce	VBN	VBN	_	3	acl	_	_
8	by	by	IN	IN	_	9	case	_	_
9	deposition	deposition	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	immunoglobulin	immunoglobulin	NN	NN	_	14	compound	_	_
12	G	g	NN	NN	_	14	compound	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	9	nmod	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	expression	expression	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	chemokines	chemokine	NNS	NNS	_	18	conj	_	_
21	as	as	RB	RB	_	16	cc	_	_
22	well	well	RB	RB	_	21	mwe	_	_
23	as	as	IN	IN	_	21	mwe	_	_
24	activation	activation	NN	NN	_	16	conj	_	_
25	of	of	IN	IN	_	34	case	_	_
26	the	the	DT	DT	_	34	det	_	_
27	transcription	transcription	NN	NN	_	34	compound	_	_
28	factor	factor	NN	NN	_	34	compound	_	_
29	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
30	factor	factor	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	34	punct	_	_
32	NF	nf	NN	NN	_	34	compound	_	_
33	)	)	-RRB-	-RRB-	_	34	punct	_	_
34	-kappaB	-kappab	NN	NN	_	24	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	little	little	JJ	JJ	_	5	amod	_	_
4	direct	direct	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	2	nsubj	_	_
6	regarding	regard	VBG	VBG	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	alveolar	alveolar	JJ	JJ	_	11	amod	_	_
11	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	activation	activation	NN	NN	_	15	compound	_	_
15	events	event	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	studies	study	NNS	NNS	_	9	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	rat	rat	NN	NN	_	7	compound	_	_
7	lungs	lung	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	depleted	deplete	VBN	VBN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	alveolar	alveolar	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	airway	airway	NN	NN	_	15	compound	_	_
15	instillation	instillation	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	liposome-encapsulated	liposome-encapsulated	JJ	JJ	_	19	amod	_	_
18	dichloromethylene	dichloromethylene	NN	NN	_	19	compound	_	_
19	diphosphonate	diphosphonate	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	procedures	procedure	NNS	NNS	_	14	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	6	nsubj	_	_
5	greatly	greatly	RB	RB	_	6	advmod	_	_
6	reduced	reduce	VBD	VBD	_	2	acl:relcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	number	number	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	retrievable	retrievable	JJ	JJ	_	12	amod	_	_
11	alveolar	alveolar	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	suppressed	suppress	VBD	VBD	_	0	root	_	_
15	activation	activation	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	lung	lung	NN	NN	_	18	compound	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	inflammatory	inflammatory	JJ	JJ	_	22	amod	_	_
22	model	model	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	25	nmod	_	_
3	,	,	,	,	_	25	punct	_	_
4	bronchoalveolar	bronchoalveolar	JJ	JJ	_	6	amod	_	_
5	lavage	lavage	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	25	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	tumor	tumor	NN	NN	_	10	compound	_	_
9	necrosis	necrosis	NN	NN	_	10	compound	_	_
10	factor-alpha	factor-alpha	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CXC	cxc	NN	NN	_	17	compound	_	_
17	chemokine	chemokine	NN	NN	_	10	conj	_	_
18	,	,	,	,	_	17	punct	_	_
19	macrophage	macrophage	NN	NN	_	21	compound	_	_
20	inflammatory	inflammatory	JJ	JJ	_	21	amod	_	_
21	protein-2	protein-2	NN	NN	_	17	appos	_	_
22	,	,	,	,	_	17	punct	_	_
23	were	be	VBD	VBD	_	25	auxpass	_	_
24	substantially	substantially	RB	RB	_	25	advmod	_	_
25	reduced	reduce	VBN	VBN	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	parallel	parallel	NN	NN	_	18	nmod	_	_
3	,	,	,	,	_	18	punct	_	_
4	upregulation	upregulation	NN	NN	_	18	nsubjpass	_	_
5	of	of	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	lung	lung	NN	NN	_	10	compound	_	_
8	vascular	vascular	JJ	JJ	_	10	amod	_	_
9	adhesion	adhesion	NN	NN	_	10	compound	_	_
10	molecule	molecule	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	intercellular	intercellular	JJ	JJ	_	14	amod	_	_
13	adhesion	adhesion	NN	NN	_	14	compound	_	_
14	molecule-1	molecule-1	NN	NN	_	10	appos	_	_
15	,	,	,	,	_	10	punct	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	greatly	greatly	RB	RB	_	18	advmod	_	_
18	reduced	reduce	VBN	VBN	_	0	root	_	_
19	by	by	IN	IN	_	21	case	_	_
20	intrapulmonary	intrapulmonary	JJ	JJ	_	21	amod	_	_
21	instillation	instillation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	phosphonate-containing	phosphonate-containing	JJ	JJ	_	24	amod	_	_
24	liposomes	liposome	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	18	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	2	compound	_	_
2	accumulation	accumulation	NN	NN	_	11	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	development	development	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	lung	lung	NN	NN	_	7	compound	_	_
7	injury	injury	NN	NN	_	4	nmod	_	_
8	were	be	VBD	VBD	_	11	auxpass	_	_
9	also	also	RB	RB	_	11	advmod	_	_
10	substantially	substantially	RB	RB	_	11	advmod	_	_
11	diminished	diminish	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Lung	lung	NN	NN	_	2	compound	_	_
2	instillation	instillation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	TNF-alpha	tnf-alpha	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	alveolar	alveolar	JJ	JJ	_	8	amod	_	_
7	macrophage-depleted	macrophage-depleted	JJ	JJ	_	8	amod	_	_
8	rats	rat	NNS	NNS	_	2	nmod	_	_
9	restored	restore	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	13	det	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
12	activation	activation	NN	NN	_	13	compound	_	_
13	response	response	NN	NN	_	9	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	whole	whole	JJ	JJ	_	16	amod	_	_
16	lung	lung	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	,	,	,	,	_	15	punct	_	_
6	in	in	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	inflammatory	inflammatory	JJ	JJ	_	9	amod	_	_
9	model	model	NN	NN	_	15	nmod	_	_
10	,	,	,	,	_	15	punct	_	_
11	initial	initial	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	15	nsubj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	occurs	occur	VBZ	VBZ	_	3	ccomp	_	_
16	in	in	IN	IN	_	18	case	_	_
17	alveolar	alveolar	JJ	JJ	_	18	amod	_	_
18	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	ensuing	ensue	VBG	VBG	_	22	amod	_	_
22	production	production	NN	NN	_	26	nsubj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	22	nmod	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	propagate	propagate	VB	VB	_	15	conj	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	28	compound	_	_
28	activation	activation	NN	NN	_	26	dobj	_	_
29	to	to	TO	TO	_	32	case	_	_
30	other	other	JJ	JJ	_	32	amod	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	types	type	NNS	NNS	_	26	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	lung	lung	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cyclooxygenase-2	cyclooxygenase-2	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	4-trifluoromethyl	4-trifluoromethyl	NN	NN	_	7	compound	_	_
7	derivatives	derivative	NNS	NNS	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	salicylate	salicylate	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	triflusal	triflusal	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	deacetylated	deacetylate	VBN	VBN	_	16	amod	_	_
16	metabolite	metabolite	NN	NN	_	9	conj	_	_
17	,	,	,	,	_	16	punct	_	_
18	2-hydroxy-4-trifluoromethylbenzoic	2-hydroxy-4-trifluoromethylbenzoic	JJ	JJ	_	19	amod	_	_
19	acid	acid	NN	NN	_	16	appos	_	_
20	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	therapeutic	therapeutic	JJ	JJ	_	3	amod	_	_
3	potential	potential	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	drugs	drug	NNS	NNS	_	3	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	block	block	VBP	VBP	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	induction	induction	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cyclooxygenase-2	cyclooxygenase-2	NN	NN	_	9	nmod	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	emphasized	emphasize	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	When	when	WRB	WRB	_	23	advmod	_	_
2	two	two	CD	CD	_	5	nummod	_	_
3	4-trifluoromethyl	4-trifluoromethyl	NN	NN	_	5	compound	_	_
4	salicylate	salicylate	NN	NN	_	5	compound	_	_
5	derivatives	derivative	NNS	NNS	_	23	nsubjpass	_	_
6	-LSB-	-lsb-	-LRB-	-LRB-	_	8	punct	_	_
7	2-acetoxy-4-trifluoromethyl-benzoic	2-acetoxy-4-trifluoromethyl-benzoic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	5	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	triflusal	triflusal	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
14	deacetylated	deacetylate	VBN	VBN	_	17	amod	_	_
15	metabolite	metabolite	NN	NN	_	17	compound	_	_
16	2-hydroxy-4-trifluoromethylbenzoic	2-hydroxy-4-trifluoromethylbenzoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	8	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HTB	htb	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	8	punct	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	compared	compare	VBN	VBN	_	37	advcl	_	_
24	with	with	IN	IN	_	25	case	_	_
25	aspirin	aspirin	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	sodium	sodium	NN	NN	_	28	compound	_	_
28	salicylate	salicylate	NN	NN	_	25	conj	_	_
29	as	as	IN	IN	_	34	case	_	_
30	cyclooxygenase-2	cyclooxygenase-2	NN	NN	_	34	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	COX-2	cox-2	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	inhibitors	inhibitor	NNS	NNS	_	23	nmod	_	_
35	,	,	,	,	_	37	punct	_	_
36	we	we	PRP	PRP	_	37	nsubj	_	_
37	observed	observe	VBD	VBD	_	0	root	_	_
38	that	that	IN	IN	_	57	mark	_	_
39	in	in	IN	IN	_	43	case	_	_
40	bacterial	bacterial	JJ	JJ	_	41	amod	_	_
41	lipopolysaccharide-activated	lipopolysaccharide-activated	JJ	JJ	_	43	amod	_	_
42	human	human	JJ	JJ	_	43	amod	_	_
43	blood	blood	NN	NN	_	57	nmod	_	_
44	,	,	,	,	_	57	punct	_	_
45	triflusal	triflusal	NN	NN	_	57	nsubj	_	_
46	,	,	,	,	_	45	punct	_	_
47	aspirin	aspirin	NN	NN	_	45	conj	_	_
48	,	,	,	,	_	45	punct	_	_
49	and	and	CC	CC	_	45	cc	_	_
50	HTB	htb	NN	NN	_	45	conj	_	_
51	,	,	,	,	_	45	punct	_	_
52	but	but	CC	CC	_	53	cc	_	_
53	not	not	RB	RB	_	45	cc	_	_
54	sodium	sodium	NN	NN	_	55	compound	_	_
55	salicylate	salicylate	NN	NN	_	45	conj	_	_
56	,	,	,	,	_	45	punct	_	_
57	inhibited	inhibit	VBD	VBD	_	37	ccomp	_	_
58	COX-2-mediated	cox-2-mediated	JJ	JJ	_	64	amod	_	_
59	prostaglandin	prostaglandin	NN	NN	_	60	compound	_	_
60	E2	e2	NN	NN	_	64	compound	_	_
61	(	(	-LRB-	-LRB-	_	62	punct	_	_
62	PGE2	pge2	NN	NN	_	60	appos	_	_
63	)	)	-RRB-	-RRB-	_	62	punct	_	_
64	production	production	NN	NN	_	57	dobj	_	_
65	(	(	-LRB-	-LRB-	_	67	punct	_	_
66	IC50	ic50	NN	NN	_	67	nsubj	_	_
67	=	=	JJ	JJ	_	57	parataxis	_	_
68	0.16	0.16	CD	CD	_	72	nummod	_	_
69	,	,	,	,	_	72	punct	_	_
70	0.18	0.18	CD	CD	_	72	nummod	_	_
71	,	,	,	,	_	72	punct	_	_
72	0.39	0.39	CD	CD	_	77	nummod	_	_
73	,	,	,	,	_	72	punct	_	_
74	and	and	CC	CC	_	72	cc	_	_
75	&gt;	&gt;	JJR	JJR	_	72	conj	_	_
76	10	10	CD	CD	_	75	nummod	_	_
77	mM	mm	NN	NN	_	67	dobj	_	_
78	,	,	,	,	_	67	punct	_	_
79	respectively	respectively	RB	RB	_	67	advmod	_	_
80	)	)	-RRB-	-RRB-	_	67	punct	_	_
81	.	.	.	.	_	37	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	triflusal	triflusal	NN	NN	_	7	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	aspirin	aspirin	NN	NN	_	4	conj	_	_
7	inhibited	inhibit	VBD	VBD	_	0	root	_	_
8	purified	purify	VBN	VBN	_	10	amod	_	_
9	COX-2	cox-2	NN	NN	_	10	compound	_	_
10	enzyme	enzyme	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	8	advcl	_	_
3	this	this	DT	DT	_	5	det	_	_
4	apparent	apparent	JJ	JJ	_	5	amod	_	_
5	discrepancy	discrepancy	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	realized	realize	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	20	mark	_	_
10	HTB	htb	NN	NN	_	20	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	triflusal	triflusal	NN	NN	_	10	conj	_	_
13	(	(	-LRB-	-LRB-	_	10	punct	_	_
14	but	but	CC	CC	_	10	cc	_	_
15	neither	neither	CC	CC	_	16	cc:preconj	_	_
16	aspirin	aspirin	NN	NN	_	10	conj	_	_
17	nor	nor	CC	CC	_	16	cc	_	_
18	salicylate	salicylate	NN	NN	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	10	punct	_	_
20	produced	produce	VBD	VBD	_	8	ccomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	concentration-dependent	concentration-dependent	JJ	JJ	_	23	amod	_	_
23	inhibition	inhibition	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	COX-2	cox-2	NN	NN	_	27	compound	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	expression	expression	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	32	case	_	_
29	peripheral	peripheral	JJ	JJ	_	32	amod	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	mononuclear	mononuclear	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	27	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	confirmed	confirm	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	11	case	_	_
7	a	a	DT	DT	_	11	det	_	_
8	rat	rat	NN	NN	_	11	compound	_	_
9	air	air	NN	NN	_	11	compound	_	_
10	pouch	pouch	NN	NN	_	11	compound	_	_
11	model	model	NN	NN	_	5	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	11	advmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	which	which	WDT	WDT	_	21	nmod	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	aspirin	aspirin	NN	NN	_	21	nsubj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	triflusal	triflusal	NN	NN	_	18	conj	_	_
21	inhibited	inhibit	VBD	VBD	_	11	acl:relcl	_	_
22	PGE2	pge2	NN	NN	_	23	compound	_	_
23	production	production	NN	NN	_	21	dobj	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	ID50	id50	NN	NN	_	26	nsubj	_	_
26	=	=	JJ	JJ	_	21	parataxis	_	_
27	18.9	18.9	CD	CD	_	31	nummod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	11.4	11.4	CD	CD	_	27	conj	_	_
30	mg/kg	mg/kg	NN	NN	_	31	compound	_	_
31	p.o.	p.o.	NN	NN	_	26	dobj	_	_
32	,	,	,	,	_	26	punct	_	_
33	respectively	respectively	RB	RB	_	26	advmod	_	_
34	)	)	-RRB-	-RRB-	_	26	punct	_	_
35	but	but	CC	CC	_	21	cc	_	_
36	only	only	RB	RB	_	38	advmod	_	_
37	triflusal-treated	triflusal-treated	JJ	JJ	_	38	amod	_	_
38	animals	animal	NNS	NNS	_	39	nsubj	_	_
39	showed	show	VBD	VBD	_	21	conj	_	_
40	a	a	DT	DT	_	41	det	_	_
41	decrease	decrease	NN	NN	_	39	dobj	_	_
42	in	in	IN	IN	_	44	case	_	_
43	COX-2	cox-2	NN	NN	_	44	compound	_	_
44	expression	expression	NN	NN	_	41	nmod	_	_
45	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	different	different	JJ	JJ	_	3	amod	_	_
3	behavior	behavior	NN	NN	_	10	nsubj	_	_
4	may	may	MD	MD	_	10	aux	_	_
5	be	be	VB	VB	_	10	cop	_	_
6	,	,	,	,	_	10	punct	_	_
7	at	at	IN	IN	_	10	advmod	_	_
8	least	least	JJS	JJS	_	7	mwe	_	_
9	in	in	IN	IN	_	10	case	_	_
10	part	part	NN	NN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	due	due	JJ	JJ	_	15	case	_	_
13	to	to	TO	TO	_	12	mwe	_	_
14	the	the	DT	DT	_	15	det	_	_
15	ability	ability	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	HTB	htb	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	triflusal	triflusal	NN	NN	_	17	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	block	block	VB	VB	_	15	acl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	activation	activation	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	transcription	transcription	NN	NN	_	29	compound	_	_
27	factor	factor	NN	NN	_	29	compound	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	factor-kappaB	factor-kappab	NN	NN	_	23	nmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	a	a	DT	DT	_	33	det	_	_
32	higher	higher	JJR	JJR	_	33	amod	_	_
33	extent	extent	NN	NN	_	21	nmod	_	_
34	than	than	IN	IN	_	35	case	_	_
35	aspirin	aspirin	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	sodium	sodium	NN	NN	_	38	compound	_	_
38	salicylate	salicylate	NN	NN	_	35	conj	_	_
39	.	.	.	.	_	10	punct	_	_

1	Thus	thus	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	in	in	IN	IN	_	6	case	_	_
4	addition	addition	NN	NN	_	6	dep	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibiting	inhibit	VBG	VBG	_	16	advcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	COX-2	cox-2	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	at	at	IN	IN	_	12	case	_	_
11	therapeutic	therapeutic	JJ	JJ	_	12	amod	_	_
12	concentrations	concentration	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	triflusal	triflusal	NN	NN	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	able	able	JJ	JJ	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	block	block	VB	VB	_	16	xcomp	_	_
19	through	through	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	metabolite	metabolite	NN	NN	_	22	compound	_	_
22	HTB	htb	NN	NN	_	18	nmod	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	18	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	new	new	JJ	JJ	_	27	amod	_	_
27	enzyme	enzyme	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	24	punct	_	_
29	and	and	CC	CC	_	24	cc	_	_
30	hence	hence	RB	RB	_	24	advmod	_	_
31	the	the	DT	DT	_	32	det	_	_
32	resumption	resumption	NN	NN	_	24	dep	_	_
33	of	of	IN	IN	_	35	case	_	_
34	PGE2	pge2	NN	NN	_	35	compound	_	_
35	synthesis	synthesis	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	Triflusal	triflusal	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	HTB	htb	NN	NN	_	1	conj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	exert	exert	VB	VB	_	0	root	_	_
6	beneficial	beneficial	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	processes	process	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	17	nmod	_	_
12	de	de	FW	FW	_	15	amod	_	_
13	novo	novo	FW	FW	_	12	dep	_	_
14	COX-2	cox-2	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	17	nsubjpass	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	involved	involve	VBN	VBN	_	9	acl:relcl	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	,	,	,	,	_	9	punct	_	_
20	in	in	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	broader	broader	JJR	JJR	_	23	amod	_	_
23	sense	sense	NN	NN	_	27	nmod	_	_
24	,	,	,	,	_	27	punct	_	_
25	in	in	IN	IN	_	27	case	_	_
26	pathological	pathological	JJ	JJ	_	27	amod	_	_
27	situations	situation	NNS	NNS	_	9	conj	_	_
28	in	in	IN	IN	_	29	case	_	_
29	which	which	WDT	WDT	_	36	nmod	_	_
30	genes	gene	NNS	NNS	_	36	nsubjpass	_	_
31	under	under	IN	IN	_	34	case	_	_
32	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
33	factor-kappaB	factor-kappab	NN	NN	_	34	compound	_	_
34	control	control	NN	NN	_	30	nmod	_	_
35	are	be	VBP	VBP	_	36	auxpass	_	_
36	up-regulated	up-regulate	VBN	VBN	_	27	acl:relcl	_	_
37	.	.	.	.	_	5	punct	_	_

1	Vitamin	vitamin	NN	NN	_	6	compound	_	_
2	D	d	NN	NN	_	6	compound	_	_
3	receptor	receptor	NN	NN	_	6	compound	_	_
4	3'-untranslated	3'-untranslated	JJ	JJ	_	6	amod	_	_
5	region	region	NN	NN	_	6	compound	_	_
6	polymorphisms	polymorphism	NNS	NNS	_	0	root	_	_
7	:	:	:	:	_	6	punct	_	_
8	lack	lack	NN	NN	_	6	dep	_	_
9	of	of	IN	IN	_	10	case	_	_
10	effect	effect	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	stability	stability	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Allelic	allelic	JJ	JJ	_	2	amod	_	_
2	variation	variation	NN	NN	_	17	nsubjpass	_	_
3	at	at	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	3'-end	3'-end	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	14	case	_	_
7	the	the	DT	DT	_	14	det	_	_
8	vitamin	vitamin	NN	NN	_	14	compound	_	_
9	D	d	NN	NN	_	14	compound	_	_
10	receptor	receptor	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	VDR	vdr	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	gene	gene	NN	NN	_	5	nmod	_	_
15	has	have	VBZ	VBZ	_	17	aux	_	_
16	been	be	VBN	VBN	_	17	auxpass	_	_
17	associated	associate	VBN	VBN	_	0	root	_	_
18	with	with	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	3-5-fold	3-5-fold	RB	RB	_	21	advmod	_	_
21	increased	increase	VBN	VBN	_	22	amod	_	_
22	risk	risk	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	24	mark	_	_
24	developing	develop	VBG	VBG	_	22	acl	_	_
25	prostate	prostate	NN	NN	_	26	compound	_	_
26	cancer	cancer	NN	NN	_	24	dobj	_	_
27	and	and	CC	CC	_	22	cc	_	_
28	with	with	IN	IN	_	29	case	_	_
29	differences	difference	NNS	NNS	_	22	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	bone	bone	NN	NN	_	32	compound	_	_
32	mineralization	mineralization	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	genetic	genetic	JJ	JJ	_	3	amod	_	_
3	diversity	diversity	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	alter	alter	VB	VB	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	VDR	vdr	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	6	dobj	_	_
10	structurally	structurally	RB	RB	_	6	advmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	but	but	CC	CC	_	6	cc	_	_
13	instead	instead	RB	RB	_	6	advmod	_	_
14	may	may	MD	MD	_	19	aux	_	_
15	be	be	VB	VB	_	19	cop	_	_
16	a	a	DT	DT	_	19	det	_	_
17	marker	marker	NN	NN	_	19	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	s	s	NNS	NNS	_	6	dep	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	of	of	IN	IN	_	25	case	_	_
22	other	other	JJ	JJ	_	25	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	nearby	nearby	JJ	JJ	_	22	dep	_	_
25	polymorphisms	polymorphism	NNS	NNS	_	19	nmod	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	influence	influence	VBP	VBP	_	25	acl:relcl	_	_
28	message	message	NN	NN	_	27	dobj	_	_
29	stability	stability	NN	NN	_	28	dep	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	translation	translation	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	work	work	NN	NN	_	6	nsubjpass	_	_
3	reported	report	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	instigated	instigate	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	ccomp	_	_
9	additional	additional	JJ	JJ	_	12	amod	_	_
10	VDR	vdr	NN	NN	_	12	compound	_	_
11	3'-UTR	3'-utr	NN	NN	_	12	compound	_	_
12	polymorphisms	polymorphism	NNS	NNS	_	8	dobj	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	may	may	MD	MD	_	15	aux	_	_
15	have	have	VB	VB	_	12	acl:relcl	_	_
16	functional	functional	JJ	JJ	_	17	amod	_	_
17	significance	significance	NN	NN	_	15	dobj	_	_
18	and	and	CC	CC	_	8	cc	_	_
19	to	to	TO	TO	_	21	mark	_	_
20	then	then	RB	RB	_	21	advmod	_	_
21	test	test	VB	VB	_	8	conj	_	_
22	whether	whether	IN	IN	_	26	mark	_	_
23	these	these	DT	DT	_	25	det	_	_
24	genetic	genetic	JJ	JJ	_	25	amod	_	_
25	variants	variant	NNS	NNS	_	26	nsubj	_	_
26	alter	alter	VBP	VBP	_	21	ccomp	_	_
27	message	message	NN	NN	_	28	compound	_	_
28	stability	stability	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	6	punct	_	_

1	Initially	initially	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	four	four	CD	CD	_	9	nummod	_	_
4	novel	novel	JJ	JJ	_	9	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	frequently	frequently	RB	RB	_	7	advmod	_	_
7	occurring	occur	VBG	VBG	_	4	dep	_	_
8	sequence	sequence	NN	NN	_	9	compound	_	_
9	variants	variant	NNS	NNS	_	11	nsubjpass	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	identified	identify	VBN	VBN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	associated	associate	VBD	VBD	_	11	ccomp	_	_
14	with	with	IN	IN	_	17	case	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	common	common	JJ	JJ	_	17	amod	_	_
17	haplotypes	haplotype	NNS	NNS	_	13	nmod	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	described	describe	VBN	VBN	_	17	acl:relcl	_	_
21	previously	previously	RB	RB	_	20	advmod	_	_
22	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	common	common	JJ	JJ	_	4	amod	_	_
3	sequence	sequence	NN	NN	_	4	compound	_	_
4	variants	variant	NNS	NNS	_	7	nsubjpass	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	within	within	IN	IN	_	11	case	_	_
9	three	three	CD	CD	_	11	nummod	_	_
10	message-destabilizing	message-destabilizing	JJ	JJ	_	11	amod	_	_
11	elements	element	NNS	NNS	_	7	nmod	_	_
12	that	that	WDT	WDT	_	14	dobj	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	mapped	map	VBD	VBD	_	11	acl:relcl	_	_
15	within	within	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	3'-UTR	3'-utr	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	vitamin	vitamin	NN	NN	_	23	compound	_	_
21	D	d	NN	NN	_	23	compound	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	mRNA	mrna	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	two	two	CD	CD	_	7	nummod	_	_
5	VDR	vdr	NN	NN	_	7	compound	_	_
6	3'-UTR	3'-utr	NN	NN	_	7	compound	_	_
7	haplotypes	haplotype	NNS	NNS	_	8	nsubj	_	_
8	conferred	confer	VBD	VBD	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	identical	identical	JJ	JJ	_	11	amod	_	_
11	half-life	half-life	NN	NN	_	8	dobj	_	_
12	on	on	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	heterologous	heterologous	JJ	JJ	_	17	amod	_	_
15	beta-globin	beta-globin	NN	NN	_	17	compound	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	gene	gene	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	in	in	IN	IN	_	23	case	_	_
20	an	a	DT	DT	_	23	det	_	_
21	in	in	FW	FW	_	23	amod	_	_
22	vitro	vitro	FW	FW	_	21	dep	_	_
23	assay	assay	NN	NN	_	8	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	therefore	therefore	RB	RB	_	3	advmod	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	common	common	JJ	JJ	_	6	amod	_	_
6	polymorphisms	polymorphism	NNS	NNS	_	13	nsubj	_	_
7	within	within	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	VDR	vdr	NN	NN	_	10	compound	_	_
10	3'-UTR	3'-utr	NN	NN	_	6	nmod	_	_
11	do	do	VBP	VBP	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	influence	influence	VB	VB	_	3	ccomp	_	_
14	message	message	NN	NN	_	15	compound	_	_
15	stability	stability	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Induction	induction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	glucocorticoids	glucocorticoid	NNS	NNS	_	2	nmod	_	_
9	:	:	:	:	_	2	punct	_	_
10	between	between	IN	IN	_	11	case	_	_
11	physiology	physiology	NN	NN	_	2	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	pharmacology	pharmacology	NN	NN	_	11	conj	_	_
14	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	physiological	physiological	JJ	JJ	_	4	amod	_	_
4	molecules	molecule	NNS	NNS	_	0	root	_	_
5	that	that	WDT	WDT	_	9	nsubjpass	_	_
6	are	be	VBP	VBP	_	9	auxpass	_	_
7	also	also	RB	RB	_	9	advmod	_	_
8	extensively	extensively	RB	RB	_	9	advmod	_	_
9	used	use	VBN	VBN	_	4	acl:relcl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	clinics	clinic	NNS	NNS	_	9	nmod	_	_
12	as	as	IN	IN	_	18	case	_	_
13	anti-inflammatory	anti-inflammatory	JJ	JJ	_	18	amod	_	_
14	,	,	,	,	_	13	punct	_	_
15	immunosuppressive	immunosuppressive	JJ	JJ	_	13	conj	_	_
16	or	or	CC	CC	_	13	cc	_	_
17	anti-tumoral	anti-tumoral	JJ	JJ	_	13	conj	_	_
18	agents	agent	NNS	NNS	_	9	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	induce	induce	VB	VB	_	0	root	_	_
4	apoptosis	apoptosis	NN	NN	_	3	dobj	_	_
5	on	on	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	play	play	VB	VB	_	3	conj	_	_
11	a	a	DT	DT	_	13	det	_	_
12	key	key	JJ	JJ	_	13	amod	_	_
13	role	role	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	physiology	physiology	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	thymic	thymic	JJ	JJ	_	19	amod	_	_
19	selection	selection	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	clinics	clinic	NNS	NNS	_	7	nmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	molecules	molecule	NNS	NNS	_	7	nsubjpass	_	_
5	are	be	VBP	VBP	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	used	use	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
10	potencies	potency	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	inducing	induce	VBG	VBG	_	10	acl	_	_
13	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	malignant	malignant	JJ	JJ	_	17	amod	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	3	nsubj	_	_
2	are	be	VBP	VBP	_	3	aux	_	_
3	mediating	mediate	VBG	VBG	_	0	root	_	_
4	their	they	PRP$	PRP$	_	5	nmod:poss	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	after	after	IN	IN	_	7	mark	_	_
7	binding	bind	VBG	VBG	_	3	advcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	intracellular	intracellular	JJ	JJ	_	11	amod	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	belonging	belong	VBG	VBG	_	11	acl	_	_
13	to	to	TO	TO	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	steroid	steroid	NN	NN	_	17	compound	_	_
16	receptor	receptor	NN	NN	_	17	compound	_	_
17	superfamily	superfamily	NN	NN	_	12	nmod	_	_
18	:	:	:	:	_	11	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	glucocorticoid	glucocorticoid	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	11	dep	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	GR	gr	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	3	punct	_	_

1	Once	once	IN	IN	_	2	mark	_	_
2	activated	activate	VBN	VBN	_	8	advcl	_	_
3	,	,	,	,	_	8	punct	_	_
4	the	the	DT	DT	_	5	det	_	_
5	GR	gr	NN	NN	_	8	nsubj	_	_
6	,	,	,	,	_	8	punct	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	mediate	mediate	VB	VB	_	0	root	_	_
9	his	he	PRP$	PRP$	_	10	nmod:poss	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	through	through	IN	IN	_	13	case	_	_
12	direct	direct	JJ	JJ	_	13	amod	_	_
13	binding	binding	NN	NN	_	8	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	DNA	dna	NN	NN	_	13	nmod	_	_
17	or	or	CC	CC	_	13	cc	_	_
18	via	via	IN	IN	_	20	case	_	_
19	protein/protein	protein/protein	NN	NN	_	20	compound	_	_
20	interactions	interaction	NNS	NNS	_	13	conj	_	_
21	with	with	IN	IN	_	23	case	_	_
22	transcription	transcription	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Depending	depend	VBG	VBG	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	type	type	NN	NN	_	15	advcl	_	_
5	of	of	IN	IN	_	6	case	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
7	,	,	,	,	_	15	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	mechanism	mechanism	NN	NN	_	15	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
12	induced	induce	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	12	nmod	_	_
15	fall	fall	VBP	VBP	_	0	root	_	_
16	roughly	roughly	RB	RB	_	19	advmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	two	two	CD	CD	_	19	nummod	_	_
19	categories	category	NNS	NNS	_	15	nmod	_	_
20	:	:	:	:	_	19	punct	_	_
21	induction	induction	NN	NN	_	19	dep	_	_
22	of	of	IN	IN	_	25	case	_	_
23	``	``	``	``	_	25	punct	_	_
24	death	death	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	21	nmod	_	_
26	by	by	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	activated	activate	VBN	VBN	_	29	amod	_	_
29	GR	gr	NN	NN	_	21	nmod	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	I	i	NN	NN	_	33	compound	_	_
32	kappa	kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	29	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	c-jun	c-jun	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	or	or	CC	CC	_	21	cc	_	_
38	repression	repression	NN	NN	_	21	conj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	survival	survival	NN	NN	_	41	compound	_	_
41	factors	factor	NNS	NNS	_	38	nmod	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	AP-1	ap-1	NN	NN	_	41	dep	_	_
44	,	,	,	,	_	43	punct	_	_
45	c-Myc	c-myc	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	43	punct	_	_
47	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	case	case	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	thymic	thymic	JJ	JJ	_	6	amod	_	_
6	selection	selection	NN	NN	_	3	nmod	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	more	more	RBR	RBR	_	11	advmod	_	_
11	subtle	subtle	JJ	JJ	_	0	root	_	_
12	depending	depend	VBG	VBG	_	16	case	_	_
13	on	on	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	mutual	mutual	JJ	JJ	_	16	amod	_	_
16	repression	repression	NN	NN	_	11	advcl	_	_
17	of	of	IN	IN	_	18	case	_	_
18	Nur77	nur77	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	GR	gr	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	11	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IkappaBalpha	ikappabalpha	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	nucleus	nucleus	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	According	accord	VBG	VBG	_	4	case	_	_
2	to	to	TO	TO	_	1	mwe	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	models	model	NNS	NNS	_	19	nmod	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inhibitory	inhibitory	JJ	JJ	_	7	amod	_	_
7	capacity	capacity	NN	NN	_	19	nsubjpass	_	_
8	of	of	IN	IN	_	15	case	_	_
9	I	i	NN	NN	_	15	compound	_	_
10	(	(	-LRB-	-LRB-	_	15	punct	_	_
11	kappa	kappa	NN	NN	_	15	compound	_	_
12	)	)	-RRB-	-RRB-	_	15	punct	_	_
13	B	b	NN	NN	_	15	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	alpha	alpha	NN	NN	_	7	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	would	would	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	mediated	mediate	VBN	VBN	_	0	root	_	_
20	through	through	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	retention	retention	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Rel/NF-kappaB	rel/nf-kappab	NN	NN	_	25	compound	_	_
25	proteins	protein	NNS	NNS	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	cytosol	cytosol	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	19	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	I	i	NN	NN	_	9	compound	_	_
4	(	(	-LRB-	-LRB-	_	9	punct	_	_
5	kappa	kappa	NN	NN	_	9	compound	_	_
6	)	)	-RRB-	-RRB-	_	9	punct	_	_
7	B	b	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	alpha	alpha	NN	NN	_	14	nsubjpass	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	has	have	VBZ	VBZ	_	14	aux	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	14	dep	_	_
18	of	of	IN	IN	_	20	case	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	when	when	WRB	WRB	_	23	advmod	_	_
23	overexpressed	overexpress	VBN	VBN	_	17	conj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	transient	transient	JJ	JJ	_	26	amod	_	_
26	transfection	transfection	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	14	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	25	dep	_	_
3	better	better	JJR	JJR	_	4	amod	_	_
4	insight	insight	NN	NN	_	2	dobj	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	potential	potential	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	17	case	_	_
10	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
11	I	i	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	kappa	kappa	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	alpha	alpha	NN	NN	_	8	nmod	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	in	in	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	physiological	physiological	JJ	JJ	_	22	amod	_	_
22	context	context	NN	NN	_	8	nmod	_	_
23	we	we	PRP	PRP	_	25	nsubj	_	_
24	have	have	VBP	VBP	_	25	aux	_	_
25	analysed	analyse	VBN	VBN	_	0	root	_	_
26	its	its	PRP$	PRP$	_	27	nmod:poss	_	_
27	presence	presence	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	nucleus	nucleus	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	36	case	_	_
32	human	human	JJ	JJ	_	36	amod	_	_
33	peripheral	peripheral	JJ	JJ	_	36	amod	_	_
34	blood	blood	NN	NN	_	36	compound	_	_
35	T	t	NN	NN	_	36	compound	_	_
36	lymphocytes	lymphocyte	NNS	NNS	_	30	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	PBL	pbl	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	25	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	localization	localization	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	I	i	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	kappa	kappa	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	alpha	alpha	NN	NN	_	5	nmod	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	PBL	pbl	NN	NN	_	5	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	different	different	JJ	JJ	_	19	amod	_	_
19	techniques	technique	NNS	NNS	_	2	nmod	_	_
20	:	:	:	:	_	19	punct	_	_
21	Western	western	NN	NN	_	22	compound	_	_
22	blot	blot	NN	NN	_	19	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	indirect	indirect	JJ	JJ	_	25	amod	_	_
25	immunofluorescence	immunofluorescence	NN	NN	_	22	conj	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	electron	electron	NN	NN	_	28	compound	_	_
28	microscopy	microscopy	NN	NN	_	22	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	Low	low	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	11	case	_	_
4	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
5	I	i	NN	NN	_	11	compound	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	kappa	kappa	NN	NN	_	11	compound	_	_
8	)	)	-RRB-	-RRB-	_	11	punct	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	alpha	alpha	NN	NN	_	2	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	17	case	_	_
16	resting	rest	VBG	VBG	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	whereas	whereas	IN	IN	_	14	dep	_	_
19	a	a	DT	DT	_	20	det	_	_
20	superinduction	superinduction	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	obtained	obtain	VBN	VBN	_	14	parataxis	_	_
23	after	after	IN	IN	_	25	case	_	_
24	PMA	pma	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	pool	pool	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	11	case	_	_
5	I	i	NN	NN	_	11	compound	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	kappa	kappa	NN	NN	_	11	compound	_	_
8	)	)	-RRB-	-RRB-	_	11	punct	_	_
9	B	b	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	alpha	alpha	NN	NN	_	3	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	showed	show	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	16	det	_	_
15	higher	higher	JJR	JJR	_	16	amod	_	_
16	stability	stability	NN	NN	_	13	dobj	_	_
17	than	than	IN	IN	_	25	case	_	_
18	cytosolic	cytosolic	JJ	JJ	_	25	amod	_	_
19	I	i	NN	NN	_	25	compound	_	_
20	(	(	-LRB-	-LRB-	_	25	punct	_	_
21	kappa	kappa	NN	NN	_	25	compound	_	_
22	)	)	-RRB-	-RRB-	_	25	punct	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	alpha	alpha	NN	NN	_	16	nmod	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	and	and	CC	CC	_	13	cc	_	_
28	was	be	VBD	VBD	_	30	cop	_	_
29	partially	partially	RB	RB	_	30	advmod	_	_
30	independent	independent	JJ	JJ	_	13	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	resynthesis	resynthesis	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	protein	protein	NN	NN	_	33	nmod	_	_
37	.	.	.	.	_	13	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	17	advmod	_	_
2	,	,	,	,	_	17	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	17	nsubj	_	_
5	of	of	IN	IN	_	13	case	_	_
6	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
7	I	i	NN	NN	_	13	compound	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	kappa	kappa	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	alpha	alpha	NN	NN	_	4	nmod	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	inhibit	inhibit	VB	VB	_	0	root	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	19	compound	_	_
19	binding	binding	NN	NN	_	17	dobj	_	_
20	to	to	TO	TO	_	21	case	_	_
21	DNA	dna	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	this	this	DT	DT	_	24	det	_	_
24	phenomenon	phenomenon	NN	NN	_	30	nsubj	_	_
25	was	be	VBD	VBD	_	30	cop	_	_
26	not	not	RB	RB	_	30	neg	_	_
27	due	due	JJ	JJ	_	30	case	_	_
28	to	to	TO	TO	_	27	mwe	_	_
29	the	the	DT	DT	_	30	det	_	_
30	presence	presence	NN	NN	_	17	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	IkappaBbeta	ikappabbeta	NN	NN	_	30	nmod	_	_
33	at	at	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
36	level	level	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	17	punct	_	_

1	Immunoprecipitation	immunoprecipitation	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	failed	fail	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	demonstrate	demonstrate	VB	VB	_	3	xcomp	_	_
6	an	a	DT	DT	_	7	det	_	_
7	association	association	NN	NN	_	5	dobj	_	_
8	between	between	IN	IN	_	16	case	_	_
9	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
10	I	i	NN	NN	_	16	compound	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	kappa	kappa	NN	NN	_	16	compound	_	_
13	)	)	-RRB-	-RRB-	_	16	punct	_	_
14	B	b	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	alpha	alpha	NN	NN	_	7	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	proteins	protein	NNS	NNS	_	16	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	in	in	IN	IN	_	10	case	_	_
6	resting	rest	VBG	VBG	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	PMA-activated	pma-activated	JJ	JJ	_	6	conj	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	PBL	pbl	NN	NN	_	21	nmod	_	_
11	,	,	,	,	_	21	punct	_	_
12	I	i	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	kappa	kappa	NN	NN	_	18	compound	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	B	b	NN	NN	_	18	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	alpha	alpha	NN	NN	_	21	nsubj	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	present	present	JJ	JJ	_	3	ccomp	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	nucleus	nucleus	NN	NN	_	21	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	an	a	DT	DT	_	29	det	_	_
27	apparently	apparently	RB	RB	_	28	advmod	_	_
28	inactive	inactive	JJ	JJ	_	29	amod	_	_
29	form	form	NN	NN	_	21	nmod	_	_
30	unable	unable	JJ	JJ	_	29	amod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	disrupt	disrupt	VB	VB	_	30	xcomp	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
34	binding	binding	NN	NN	_	32	dobj	_	_
35	from	from	IN	IN	_	36	case	_	_
36	DNA	dna	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	9	case	_	_
7	progesterone-induced	progesterone-induced	JJ	JJ	_	9	amod	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Rat	rat	NN	NN	_	2	compound	_	_
2	spleen	spleen	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	conj	_	_
7	express	express	VBP	VBP	_	0	root	_	_
8	progesterone	progesterone	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	7	dobj	_	_
10	whose	whose	WP$	WP$	_	11	nmod:poss	_	_
11	concentration	concentration	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	increased	increase	VBN	VBN	_	9	acl:relcl	_	_
14	greatly	greatly	RB	RB	_	13	advmod	_	_
15	during	during	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	early	early	JJ	JJ	_	18	amod	_	_
18	phase	phase	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	pregnancy	pregnancy	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	stimulation	stimulation	NN	NN	_	10	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	progesterone	progesterone	NN	NN	_	2	nmod	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	receptors	receptor	NNS	NNS	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	aux	_	_
10	augmented	augmented	JJ	JJ	_	0	root	_	_
11	2-3	2-3	CD	CD	_	12	dep	_	_
12	times	time	NNS	NNS	_	10	advmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	cultured	culture	VBN	VBN	_	11	advcl	_	_
5	in	in	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	dep	_	_
7	presence	presence	NN	NN	_	9	dep	_	_
8	of	of	IN	IN	_	9	case	_	_
9	progesterone	progesterone	NN	NN	_	4	nmod	_	_
10	they	they	PRP	PRP	_	11	nsubj	_	_
11	released	release	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	soluble	soluble	JJ	JJ	_	14	amod	_	_
14	factor	factor	NN	NN	_	11	dobj	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	inhibited	inhibit	VBD	VBD	_	14	acl:relcl	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	immunoreactions	immunoreaction	NNS	NNS	_	16	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	MLR	mlr	NN	NN	_	18	dep	_	_
21	,	,	,	,	_	20	punct	_	_
22	CRC	crc	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	and	and	CC	CC	_	18	cc	_	_
25	cellular	cellular	JJ	JJ	_	26	amod	_	_
26	proliferation	proliferation	NN	NN	_	18	conj	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	measured	measure	VBN	VBN	_	16	advcl	_	_
29	by	by	IN	IN	_	31	case	_	_
30	thymidine	thymidine	NN	NN	_	31	compound	_	_
31	incorporation	incorporation	NN	NN	_	28	nmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	spleen-cell	spleen-cell	JJ	JJ	_	34	amod	_	_
34	culture	culture	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	factor	factor	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	synthesis	synthesis	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	anti-DNP	anti-dnp	JJ	JJ	_	9	amod	_	_
9	antibodies	antibody	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	mouse	mouse	NN	NN	_	13	compound	_	_
13	hybridoma	hybridoma	NN	NN	_	6	nmod	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	diminished	diminish	VBD	VBD	_	4	conj	_	_
16	the	the	DT	DT	_	17	det	_	_
17	proportion	proportion	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	cells	cell	NNS	NNS	_	17	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	phase	phase	NN	NN	_	22	compound	_	_
22	S	s	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	percentage	percentage	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	asymmetric	asymmetric	JJ	JJ	_	7	amod	_	_
7	molecules	molecule	NNS	NNS	_	4	nmod	_	_
8	produced	produce	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	hybridoma	hybridoma	NN	NN	_	8	nmod	_	_
12	remained	remain	VBD	VBD	_	0	root	_	_
13	unaltered	unaltered	JJ	JJ	_	12	xcomp	_	_
14	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	soluble	soluble	JJ	JJ	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	13	nsubj	_	_
9	released	release	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	rat	rat	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	modulate	modulate	VBP	VBP	_	5	ccomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	response	response	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	mother	mother	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	participate	participate	VBP	VBP	_	13	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	mechanism	mechanism	NN	NN	_	21	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	protects	protect	VBZ	VBZ	_	24	acl:relcl	_	_
27	the	the	DT	DT	_	28	det	_	_
28	fetus	fetus	NN	NN	_	26	dobj	_	_
29	against	against	IN	IN	_	31	case	_	_
30	antipaternal	antipaternal	JJ	JJ	_	31	amod	_	_
31	antibodies	antibody	NNS	NNS	_	26	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	PGG-glucan	pgg-glucan	NN	NN	_	7	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	soluble	soluble	JJ	JJ	_	5	amod	_	_
5	beta-(1,3)-glucan	beta-(1,3)-glucan	NN	NN	_	1	appos	_	_
6	,	,	,	,	_	1	punct	_	_
7	enhances	enhance	VBZ	VBZ	_	0	root	_	_
8	the	the	DT	DT	_	11	det	_	_
9	oxidative	oxidative	JJ	JJ	_	11	amod	_	_
10	burst	burst	NN	NN	_	11	compound	_	_
11	response	response	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	microbicidal	microbicidal	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	11	appos	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	activates	activate	VBZ	VBZ	_	7	conj	_	_
18	an	a	DT	DT	_	21	det	_	_
19	NF-kappa	nf-kappa	NN	NN	_	21	compound	_	_
20	B-like	b-like	JJ	JJ	_	21	amod	_	_
21	factor	factor	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	human	human	JJ	JJ	_	24	amod	_	_
24	PMN	pmn	NN	NN	_	21	nmod	_	_
25	:	:	:	:	_	7	punct	_	_
26	evidence	evidence	NN	NN	_	7	dep	_	_
27	for	for	IN	IN	_	31	case	_	_
28	a	a	DT	DT	_	31	det	_	_
29	glycosphingolipid	glycosphingolipid	NN	NN	_	31	compound	_	_
30	beta-(1,3)-glucan	beta-(1,3)-glucan	NN	NN	_	31	compound	_	_
31	receptor	receptor	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	PGG-Glucan	pgg-glucan	NN	NN	_	22	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	8	det	_	_
4	soluble	soluble	JJ	JJ	_	8	amod	_	_
5	beta-(1,6)-branched	beta-(1,6)-branched	JJ	JJ	_	8	amod	_	_
6	beta-(1,3)-linked	beta-(1,3)-linked	JJ	JJ	_	8	amod	_	_
7	glucose	glucose	NN	NN	_	8	compound	_	_
8	homopolymer	homopolymer	NN	NN	_	1	appos	_	_
9	derived	derive	VBN	VBN	_	8	acl	_	_
10	from	from	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	wall	wall	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	yeast	yeast	NN	NN	_	13	nmod	_	_
17	Saccharomyces	saccharomyces	FW	FW	_	16	compound	_	_
18	cerevisiae	cerevisiae	FW	FW	_	16	dep	_	_
19	,	,	,	,	_	1	punct	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	an	a	DT	DT	_	22	det	_	_
22	immunomodulator	immunomodulator	NN	NN	_	0	root	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	enhances	enhance	VBZ	VBZ	_	22	acl:relcl	_	_
25	leukocyte	leukocyte	NN	NN	_	27	compound	_	_
26	anti-infective	anti-infective	JJ	JJ	_	27	amod	_	_
27	activity	activity	NN	NN	_	24	dobj	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	enhances	enhance	VBZ	VBZ	_	24	conj	_	_
30	myeloid	myeloid	JJ	JJ	_	34	amod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	megakaryocyte	megakaryocyte	NN	NN	_	33	compound	_	_
33	progenitor	progenitor	NN	NN	_	30	conj	_	_
34	proliferation	proliferation	NN	NN	_	29	dobj	_	_
35	.	.	.	.	_	22	punct	_	_

1	Incubation	incubation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	whole	whole	JJ	JJ	_	5	amod	_	_
5	blood	blood	NN	NN	_	1	nmod	_	_
6	with	with	IN	IN	_	7	case	_	_
7	PGG-Glucan	pgg-glucan	NN	NN	_	1	nmod	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	enhanced	enhance	VBD	VBD	_	0	root	_	_
10	the	the	DT	DT	_	13	det	_	_
11	oxidative	oxidative	JJ	JJ	_	13	amod	_	_
12	burst	burst	NN	NN	_	13	compound	_	_
13	response	response	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	subsequently	subsequently	RB	RB	_	18	advmod	_	_
16	isolated	isolate	VBN	VBN	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	leukocytes	leukocyte	NNS	NNS	_	13	nmod	_	_
19	to	to	TO	TO	_	24	case	_	_
20	both	both	CC	CC	_	21	cc:preconj	_	_
21	soluble	soluble	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	particulate	particulate	JJ	JJ	_	21	conj	_	_
24	activators	activator	NNS	NNS	_	13	nmod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	dose-dependent	dose-dependent	JJ	JJ	_	28	amod	_	_
28	manner	manner	NN	NN	_	9	nmod	_	_
29	,	,	,	,	_	9	punct	_	_
30	and	and	CC	CC	_	9	cc	_	_
31	increased	increase	VBD	VBD	_	9	conj	_	_
32	leukocyte	leukocyte	NN	NN	_	34	compound	_	_
33	microbicidal	microbicidal	JJ	JJ	_	34	amod	_	_
34	activity	activity	NN	NN	_	31	dobj	_	_
35	.	.	.	.	_	9	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	evidence	evidence	NN	NN	_	8	nsubjpass	_	_
3	for	for	IN	IN	_	6	case	_	_
4	inflammatory	inflammatory	JJ	JJ	_	6	amod	_	_
5	cytokine	cytokine	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	obtained	obtain	VBN	VBN	_	0	root	_	_
9	under	under	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	conditions	condition	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	PGG-Glucan	pgg-glucan	NN	NN	_	8	nsubj	_	_
8	induced	induce	VBD	VBD	_	5	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	16	case	_	_
12	an	a	DT	DT	_	16	det	_	_
13	NF-kappaB-like	nf-kappab-like	JJ	JJ	_	16	amod	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	10	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	purified	purify	VBN	VBN	_	20	amod	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	neutrophils	neutrophil	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	3H-PGG-Glucan	3h-pgg-glucan	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	membranes	membrane	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	specific	specific	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	concentration-dependent	concentration-dependent	JJ	JJ	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	saturable	saturable	JJ	JJ	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	high	high	JJ	JJ	_	18	amod	_	_
18	affinity	affinity	NN	NN	_	10	conj	_	_
19	(	(	-LRB-	-LRB-	_	23	punct	_	_
20	Kd	kd	NN	NN	_	23	dep	_	_
21	approximately	approximately	RB	RB	_	22	advmod	_	_
22	6	6	CD	CD	_	23	nummod	_	_
23	nM	nm	NN	NN	_	18	dep	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	monoclonal	monoclonal	JJ	JJ	_	3	amod	_	_
3	antibody	antibody	NN	NN	_	10	nsubj	_	_
4	specific	specific	JJ	JJ	_	3	amod	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	glycosphingolipid	glycosphingolipid	NN	NN	_	8	compound	_	_
8	lactosylceramide	lactosylceramide	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	10	cop	_	_
10	able	able	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	inhibit	inhibit	VB	VB	_	10	xcomp	_	_
13	activation	activation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	NF-kappaB-like	nf-kappab-like	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	by	by	IN	IN	_	19	case	_	_
19	PGG-Glucan	pgg-glucan	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	ligand	ligand	NN	NN	_	24	compound	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	data	datum	NNS	NNS	_	30	nsubj	_	_
25	,	,	,	,	_	24	punct	_	_
26	including	include	VBG	VBG	_	28	case	_	_
27	polysaccharide	polysaccharide	NN	NN	_	28	compound	_	_
28	specificity	specificity	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	24	punct	_	_
30	suggested	suggest	VBD	VBD	_	10	conj	_	_
31	that	that	IN	IN	_	37	mark	_	_
32	the	the	DT	DT	_	35	det	_	_
33	PGG-Glucan	pgg-glucan	NN	NN	_	35	compound	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	moiety	moiety	NN	NN	_	37	nsubj	_	_
36	was	be	VBD	VBD	_	37	cop	_	_
37	lactosylceramide	lactosylceramide	NN	NN	_	30	ccomp	_	_
38	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	PGG-Glucan	pgg-glucan	NN	NN	_	6	nsubj	_	_
6	enhances	enhance	VBZ	VBZ	_	3	ccomp	_	_
7	neutrophil	neutrophil	NN	NN	_	9	compound	_	_
8	anti-microbial	anti-microbial	JJ	JJ	_	9	amod	_	_
9	functions	function	NNS	NNS	_	6	dobj	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	that	that	IN	IN	_	20	mark	_	_
12	interaction	interaction	NN	NN	_	20	nsubjpass	_	_
13	between	between	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	beta-glucan	beta-glucan	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	neutrophils	neutrophil	NNS	NNS	_	15	conj	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	mediated	mediate	VBN	VBN	_	6	conj	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	glycosphingolipid	glycosphingolipid	NN	NN	_	24	compound	_	_
24	lactosylceramide	lactosylceramide	NN	NN	_	20	nmod	_	_
25	present	present	JJ	JJ	_	24	amod	_	_
26	at	at	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	surface	surface	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Cleavage	cleavage	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	transcription	transcription	NN	NN	_	5	compound	_	_
4	factor	factor	NN	NN	_	5	compound	_	_
5	SP1	sp1	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	caspases	caspase	NNS	NNS	_	1	nmod	_	_
8	during	during	IN	IN	_	11	case	_	_
9	anti-IgM-induced	anti-igm-induced	JJ	JJ	_	11	amod	_	_
10	B-cell	b-cell	NN	NN	_	11	compound	_	_
11	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	instrumental	instrumental	JJ	JJ	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	processes	process	NNS	NNS	_	3	nmod	_	_
7	generating	generate	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	diversity	diversity	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	B-cell	b-cell	NN	NN	_	13	compound	_	_
13	repertoire	repertoire	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Autoreactive	autoreactive	JJ	JJ	_	2	amod	_	_
2	B-cells	b-cell	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	eliminated	eliminate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	anti-IgM	anti-igm	JJ	JJ	_	7	amod	_	_
7	crosslinking	crosslinking	NN	NN	_	4	nmod	_	_
8	after	after	IN	IN	_	9	mark	_	_
9	encountering	encounter	VBG	VBG	_	4	advcl	_	_
10	self-antigens	self-antigen	NNS	NNS	_	9	dobj	_	_
11	,	,	,	,	_	4	punct	_	_
12	but	but	CC	CC	_	4	cc	_	_
13	precise	precise	JJ	JJ	_	14	amod	_	_
14	mechanisms	mechanism	NNS	NNS	_	23	nsubjpass	_	_
15	leading	lead	VBG	VBG	_	14	acl	_	_
16	to	to	TO	TO	_	18	case	_	_
17	B-cell	b-cell	NN	NN	_	18	compound	_	_
18	apoptosis	apoptosis	NN	NN	_	15	nmod	_	_
19	are	be	VBP	VBP	_	23	auxpass	_	_
20	still	still	RB	RB	_	23	advmod	_	_
21	not	not	RB	RB	_	22	dep	_	_
22	well	well	RB	RB	_	23	advmod	_	_
23	understood	understand	VBN	VBN	_	4	conj	_	_
24	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cleavage	cleavage	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	SP1	sp1	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	18	case	_	_
12	the	the	DT	DT	_	18	det	_	_
13	human	human	JJ	JJ	_	18	amod	_	_
14	Burkitt	burkitt	NN	NN	_	18	compound	_	_
15	lymphoma	lymphoma	NN	NN	_	18	compound	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	line	line	NN	NN	_	18	compound	_	_
18	BL60	bl60	NN	NN	_	10	nmod	_	_
19	during	during	IN	IN	_	21	case	_	_
20	anti-IgM-induced	anti-igm-induced	JJ	JJ	_	21	amod	_	_
21	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	two	two	CD	CD	_	7	nummod	_	_
6	cleavage	cleavage	NN	NN	_	7	compound	_	_
7	products	product	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	14	case	_	_
9	approximately	approximately	RB	RB	_	11	advmod	_	_
10	68	68	CD	CD	_	11	nummod	_	_
11	kDa	kda	NN	NN	_	14	nummod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	45	45	CD	CD	_	11	conj	_	_
14	kDa	kda	NN	NN	_	7	nmod	_	_
15	after	after	IN	IN	_	16	case	_	_
16	induction	induction	NN	NN	_	7	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Cleavage	cleavage	NN	NN	_	5	nsubjpass	_	_
2	could	could	MD	MD	_	5	aux	_	_
3	be	be	VB	VB	_	5	auxpass	_	_
4	completely	completely	RB	RB	_	5	advmod	_	_
5	inhibited	inhibit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	zDEVD-fmk	zdevd-fmk	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	an	a	DT	DT	_	10	det	_	_
10	inhibitor	inhibitor	NN	NN	_	7	appos	_	_
11	specific	specific	JJ	JJ	_	10	amod	_	_
12	for	for	IN	IN	_	15	case	_	_
13	caspase	caspase	NN	NN	_	15	compound	_	_
14	3-like	3-like	JJ	JJ	_	15	amod	_	_
15	proteases	protease	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	In-vitro	in-vitro	FW	FW	_	2	compound	_	_
2	cleavage	cleavage	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	recombinant	recombinant	JJ	JJ	_	5	amod	_	_
5	SP1	sp1	NN	NN	_	2	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	recombinant	recombinant	JJ	JJ	_	8	amod	_	_
8	caspase	caspase	NN	NN	_	2	nmod	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CPP32	cpp32	NN	NN	_	8	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	or	or	CC	CC	_	8	cc	_	_
14	caspase	caspase	NN	NN	_	8	conj	_	_
15	7	7	CD	CD	_	14	nummod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Mch	mch	NN	NN	_	14	appos	_	_
18	3	3	CD	CD	_	17	nummod	_	_
19	)	)	-RRB-	-RRB-	_	17	punct	_	_
20	results	result	VBZ	VBZ	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	similar	similar	JJ	JJ	_	24	amod	_	_
23	cleavage	cleavage	NN	NN	_	24	compound	_	_
24	products	product	NNS	NNS	_	20	nmod	_	_
25	as	as	IN	IN	_	26	case	_	_
26	those	those	DT	DT	_	24	nmod	_	_
27	observed	observe	VBN	VBN	_	26	acl	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vivo	vivo	FW	FW	_	27	advmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	Recombinant	recombinant	JJ	JJ	_	2	amod	_	_
2	caspase	caspase	NN	NN	_	9	nsubj	_	_
3	6	6	CD	CD	_	2	nummod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	Mch	mch	NN	NN	_	2	appos	_	_
6	2	2	CD	CD	_	5	nummod	_	_
7	)	)	-RRB-	-RRB-	_	5	punct	_	_
8	primarily	primarily	RB	RB	_	9	advmod	_	_
9	generates	generate	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	13	det	_	_
11	68-kDa	68-kda	JJ	JJ	_	13	amod	_	_
12	cleavage	cleavage	NN	NN	_	13	compound	_	_
13	product	product	NN	NN	_	9	dobj	_	_
14	,	,	,	,	_	9	punct	_	_
15	as	as	IN	IN	_	16	mark	_	_
16	observed	observe	VBN	VBN	_	9	advcl	_	_
17	after	after	IN	IN	_	23	mark	_	_
18	calcium	calcium	NN	NN	_	19	compound	_	_
19	ionophore	ionophore	NN	NN	_	23	nmod:npmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	CaI	cai	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	induced	induced	JJ	JJ	_	16	advcl	_	_
24	B-cell	b-cell	NN	NN	_	23	dep	_	_
25	apoptosis	apoptosis	NN	NN	_	23	dep	_	_
26	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	caspase	caspase	NN	NN	_	11	nsubj	_	_
5	1	1	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	ICE	ice	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	cleave	cleave	VB	VB	_	0	root	_	_
12	SP1	sp1	NN	NN	_	11	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	vitro	vitro	FW	FW	_	11	advmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	time	time	NN	NN	_	3	compound	_	_
3	course	course	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	SP1	sp1	NN	NN	_	6	compound	_	_
6	cleavage	cleavage	NN	NN	_	3	nmod	_	_
7	during	during	IN	IN	_	9	case	_	_
8	anti-IgM-induced	anti-igm-induced	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	paralleled	parallel	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	an	a	DT	DT	_	14	det	_	_
14	increase	increase	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	caspase	caspase	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	14	nmod	_	_
18	measured	measure	VBN	VBN	_	14	acl	_	_
19	by	by	IN	IN	_	24	case	_	_
20	DEVD-p-nitroanilide	devd-p-nitroanilide	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	DEVD-pNA	devd-pna	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	cleavage	cleavage	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	DNA	dna	NN	NN	_	3	compound	_	_
2	band-shift	band-shift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	decrease	decrease	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	intensity	intensity	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	full	full	JJ	JJ	_	13	dep	_	_
13	length	length	NN	NN	_	15	amod	_	_
14	SP1/DNA	sp1/dna	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	an	a	DT	DT	_	18	det	_	_
18	increase	increase	NN	NN	_	6	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	intensity	intensity	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	smaller	smaller	JJR	JJR	_	25	amod	_	_
25	complex	complex	NN	NN	_	21	nmod	_	_
26	due	due	JJ	JJ	_	29	case	_	_
27	to	to	TO	TO	_	26	mwe	_	_
28	the	the	DT	DT	_	29	det	_	_
29	binding	binding	NN	NN	_	6	nmod	_	_
30	of	of	IN	IN	_	34	case	_	_
31	one	one	CD	CD	_	34	nummod	_	_
32	SP1	sp1	NN	NN	_	34	compound	_	_
33	cleavage	cleavage	NN	NN	_	34	compound	_	_
34	product	product	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	Edman	edman	NN	NN	_	3	compound	_	_
3	sequencing	sequencing	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	could	could	MD	MD	_	6	aux	_	_
6	identify	identify	VB	VB	_	0	root	_	_
7	a	a	DT	DT	_	11	det	_	_
8	caspase	caspase	NN	NN	_	11	compound	_	_
9	3	3	CD	CD	_	11	nummod	_	_
10	cleavage	cleavage	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	6	dobj	_	_
12	after	after	IN	IN	_	13	case	_	_
13	Asp584	asp584	NN	NN	_	6	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	D584AQPQAGR	d584aqpqagr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	6	punct	_	_
18	generating	generate	VBG	VBG	_	6	advcl	_	_
19	a	a	DT	DT	_	24	det	_	_
20	22-kDa	22-kda	JJ	JJ	_	24	amod	_	_
21	C-terminal	c-terminal	JJ	JJ	_	24	amod	_	_
22	SP1	sp1	NN	NN	_	24	compound	_	_
23	protein	protein	NN	NN	_	24	compound	_	_
24	fragment	fragment	NN	NN	_	18	dobj	_	_
25	which	which	WDT	WDT	_	27	nsubj	_	_
26	still	still	RB	RB	_	27	advmod	_	_
27	contains	contain	VBZ	VBZ	_	24	acl:relcl	_	_
28	the	the	DT	DT	_	31	det	_	_
29	DNA	dna	NN	NN	_	31	compound	_	_
30	binding	binding	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	27	dobj	_	_
32	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cleavage	cleavage	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	transcription	transcription	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	SP1	sp1	NN	NN	_	5	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	14	advmod	_	_
14	and	and	CC	CC	_	3	advmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vitro	vitro	FW	FW	_	14	advmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	underlining	underline	VBG	VBG	_	3	advcl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	central	central	JJ	JJ	_	21	amod	_	_
21	role	role	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	caspase	caspase	NN	NN	_	25	compound	_	_
24	3-like	3-like	JJ	JJ	_	25	amod	_	_
25	proteases	protease	NNS	NNS	_	21	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	process	process	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	anti-IgM-induced	anti-igm-induced	JJ	JJ	_	31	amod	_	_
31	apoptosis	apoptosis	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Spi-C	spi-c	NN	NN	_	0	root	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	novel	novel	JJ	JJ	_	6	amod	_	_
5	Ets	ets	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	appos	_	_
7	that	that	WDT	WDT	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	temporally	temporally	RB	RB	_	10	advmod	_	_
10	regulated	regulate	VBN	VBN	_	6	acl:relcl	_	_
11	during	during	IN	IN	_	14	case	_	_
12	B	b	NN	NN	_	14	compound	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	development	development	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	Ets	ets	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	isolated	isolate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	yeast	yeast	NN	NN	_	10	compound	_	_
9	one-hybrid	one-hybrid	JJ	JJ	_	10	amod	_	_
10	screening	screening	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cDNA	cdna	NN	NN	_	14	compound	_	_
14	library	library	NN	NN	_	10	nmod	_	_
15	made	make	VBN	VBN	_	14	acl	_	_
16	from	from	IN	IN	_	21	case	_	_
17	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	21	amod	_	_
18	mouse	mouse	NN	NN	_	21	compound	_	_
19	splenic	splenic	JJ	JJ	_	21	amod	_	_
20	B	b	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	,	,	,	,	_	6	punct	_	_
23	using	use	VBG	VBG	_	6	xcomp	_	_
24	the	the	DT	DT	_	29	det	_	_
25	SP6	sp6	NN	NN	_	29	compound	_	_
26	kappa	kappa	NN	NN	_	29	compound	_	_
27	promoter	promoter	NN	NN	_	29	compound	_	_
28	kappaY	kappay	NN	NN	_	29	compound	_	_
29	element	element	NN	NN	_	23	dobj	_	_
30	as	as	IN	IN	_	32	case	_	_
31	a	a	DT	DT	_	32	det	_	_
32	bait	bait	NN	NN	_	23	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	Ets	et	NNS	NNS	_	4	compound	_	_
4	protein	protein	NN	NN	_	8	nsubj	_	_
5	was	be	VBD	VBD	_	8	cop	_	_
6	most	most	RBS	RBS	_	7	advmod	_	_
7	closely	closely	RB	RB	_	8	advmod	_	_
8	related	related	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	PU.1	pu.1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Spi-B	spi-b	NN	NN	_	10	conj	_	_
13	within	within	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	DNA	dna	NN	NN	_	18	compound	_	_
16	binding	binding	NN	NN	_	18	compound	_	_
17	Ets	ets	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	therefore	therefore	RB	RB	_	22	advmod	_	_
22	named	name	VBN	VBN	_	8	conj	_	_
23	Spi-C	spi-c	NN	NN	_	22	xcomp	_	_
24	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	Spi-C	spi-c	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	represent	represent	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	novel	novel	JJ	JJ	_	8	amod	_	_
8	subgroup	subgroup	NN	NN	_	5	dobj	_	_
9	within	within	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	Ets	ets	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	family	family	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	5	punct	_	_
15	as	as	IN	IN	_	17	mark	_	_
16	it	it	PRP	PRP	_	17	nsubj	_	_
17	differed	differ	VBD	VBD	_	5	advcl	_	_
18	significantly	significantly	RB	RB	_	17	advmod	_	_
19	from	from	IN	IN	_	20	case	_	_
20	Spi-B	spi-b	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	PU.1	pu.1	NN	NN	_	20	conj	_	_
23	within	within	IN	IN	_	24	case	_	_
24	helix	helix	NN	NN	_	20	nmod	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	Ets	ets	NN	NN	_	29	compound	_	_
29	domain	domain	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	Spi-C	spi-c	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	encoded	encode	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	single-copy	single-copy	JJ	JJ	_	7	amod	_	_
7	gene	gene	NN	NN	_	3	nmod	_	_
8	that	that	WDT	WDT	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	mapped	map	VBN	VBN	_	7	acl:relcl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	chromosome	chromosome	NN	NN	_	10	nmod	_	_
13	10	10	CD	CD	_	12	nummod	_	_
14	,	,	,	,	_	12	punct	_	_
15	region	region	NN	NN	_	16	compound	_	_
16	C	c	NN	NN	_	12	appos	_	_
17	.	.	.	.	_	3	punct	_	_

1	Spi-C	spi-c	NN	NN	_	2	nsubj	_	_
2	interacted	interact	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	DNA	dna	NN	NN	_	2	nmod	_	_
5	similarly	similarly	RB	RB	_	2	advmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	PU.1	pu.1	NN	NN	_	5	nmod	_	_
8	as	as	IN	IN	_	9	mark	_	_
9	judged	judge	VBN	VBN	_	2	advcl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	methylation	methylation	NN	NN	_	12	compound	_	_
12	interference	interference	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	band-shift	band-shift	NN	NN	_	18	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	site	site	NN	NN	_	17	compound	_	_
17	selection	selection	NN	NN	_	14	conj	_	_
18	analysis	analysis	NN	NN	_	12	appos	_	_
19	,	,	,	,	_	2	punct	_	_
20	and	and	CC	CC	_	2	cc	_	_
21	activated	activate	VBN	VBN	_	2	conj	_	_
22	transcription	transcription	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	28	case	_	_
24	a	a	DT	DT	_	28	det	_	_
25	kappaY	kappay	NN	NN	_	28	compound	_	_
26	element	element	NN	NN	_	28	compound	_	_
27	reporter	reporter	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	22	nmod	_	_
29	upon	upon	IN	IN	_	30	case	_	_
30	co-transfection	co-transfection	NN	NN	_	21	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	HeLa	hela	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	Spi-C	spi-c	NN	NN	_	2	compound	_	_
2	RNA	rna	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	mature	mature	JJ	JJ	_	8	amod	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	at	at	IN	IN	_	12	case	_	_
11	lower	lower	JJR	JJR	_	12	amod	_	_
12	levels	level	NNS	NNS	_	8	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	macrophages	macrophage	NNS	NNS	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	pre-B	pre-b	JJ	JJ	_	4	dep	_	_
4	cell	cell	NN	NN	_	8	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	plasma	plasma	NN	NN	_	7	compound	_	_
7	cell	cell	NN	NN	_	4	conj	_	_
8	lines	line	NNS	NNS	_	10	nsubj	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	Spi-C-negative	spi-c-negative	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	Spi-C	spi-c	NN	NN	_	19	nsubj	_	_
15	might	might	MD	MD	_	19	aux	_	_
16	be	be	VB	VB	_	19	cop	_	_
17	a	a	DT	DT	_	19	det	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	molecule	molecule	NN	NN	_	12	ccomp	_	_
20	during	during	IN	IN	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	specific	specific	JJ	JJ	_	23	amod	_	_
23	phase	phase	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	B	b	NN	NN	_	27	compound	_	_
26	lymphoid	lymphoid	JJ	JJ	_	27	amod	_	_
27	development	development	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	10	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	2	punct	_	_
2	Corticoids	corticoid	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	allergy	allergy	NN	NN	_	2	conj	_	_
5	-RSB-	-rsb-	-RRB-	-RRB-	_	2	punct	_	_

1	Inflammation	inflammation	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	constantly	constantly	RB	RB	_	4	advmod	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	allergic	allergic	JJ	JJ	_	7	amod	_	_
7	reactions	reaction	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	4	punct	_	_

1	Corticosteroids	corticosteroid	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	most	most	RBS	RBS	_	4	advmod	_	_
4	effective	effective	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	6	mark	_	_
6	preventing	prevent	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	late	late	JJ	JJ	_	9	amod	_	_
9	phase	phase	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	allergic	allergic	JJ	JJ	_	12	amod	_	_
12	reaction	reaction	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	action	action	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	glucocorticosteroids	glucocorticosteroid	NNS	NNS	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	mediated	mediate	VBN	VBN	_	0	root	_	_
7	through	through	IN	IN	_	9	case	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptors	receptor	NNS	NNS	_	6	nmod	_	_
10	present	present	JJ	JJ	_	9	amod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	cellular	cellular	JJ	JJ	_	14	amod	_	_
14	cytoplasm	cytoplasm	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	activated	activate	VBN	VBN	_	6	advcl	_	_
3	,	,	,	,	_	6	punct	_	_
4	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	6	nsubj	_	_
6	form	form	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	dimer	dimer	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	bind	bind	VBP	VBP	_	6	conj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	DNA	dna	NN	NN	_	10	nmod	_	_
13	after	after	IN	IN	_	14	case	_	_
14	migration	migration	NN	NN	_	10	nmod	_	_
15	into	into	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Interaction	interaction	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	DNA	dna	NN	NN	_	1	nmod	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	changes	change	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	rate	rate	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	leading	lead	VBG	VBG	_	5	acl	_	_
12	to	to	TO	TO	_	15	case	_	_
13	either	either	CC	CC	_	15	cc:preconj	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	11	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	repression	repression	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	interact	interact	VB	VB	_	5	xcomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	factors	factor	NNS	NNS	_	7	nmod	_	_
11	such	such	JJ	JJ	_	13	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	AP-1	ap-1	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	activator	activator	NN	NN	_	16	compound	_	_
16	protein-1	protein-1	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	of	of	IN	IN	_	20	case	_	_
19	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
20	B	b	NN	NN	_	13	nmod	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
23	factor-kappa	factor-kappa	NN	NN	_	24	compound	_	_
24	B	b	NN	NN	_	20	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	5	punct	_	_

1	Through	through	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	actions	action	NNS	NNS	_	6	nmod	_	_
4	glucocorticosteroids	glucocorticosteroid	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	susceptible	susceptible	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	modify	modify	VB	VB	_	6	xcomp	_	_
9	functions	function	NNS	NNS	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	cells	cell	NNS	NNS	_	9	nmod	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	allergic	allergic	JJ	JJ	_	17	amod	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	They	they	PRP	PRP	_	5	nsubj	_	_
2	are	be	VBP	VBP	_	5	cop	_	_
3	in	in	IN	IN	_	4	case	_	_
4	particular	particular	JJ	JJ	_	5	nmod	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	inhibit	inhibit	VB	VB	_	5	xcomp	_	_
8	most	most	JJS	JJS	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	pro-inflammatory	pro-inflammatory	JJ	JJ	_	12	amod	_	_
12	functions	function	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	eosinophils	eosinophil	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	IFNGR1	ifngr1	NN	NN	_	6	compound	_	_
4	small	small	JJ	JJ	_	6	amod	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	hotspot	hotspot	NN	NN	_	0	root	_	_
7	associated	associate	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	10	case	_	_
9	dominant	dominant	JJ	JJ	_	10	amod	_	_
10	susceptibility	susceptibility	NN	NN	_	7	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	mycobacterial	mycobacterial	JJ	JJ	_	13	amod	_	_
13	infection	infection	NN	NN	_	10	nmod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	15	punct	_	_
15	see	see	VB	VB	_	6	dep	_	_
16	comments	comment	NNS	NNS	_	15	dobj	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	immunogenetic	immunogenetic	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	severe	severe	JJ	JJ	_	6	amod	_	_
6	infections	infection	NNS	NNS	_	3	nmod	_	_
7	caused	cause	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	bacille	bacille	FW	FW	_	11	compound	_	_
10	Calmette-Guerin	calmette-guerin	FW	FW	_	11	compound	_	_
11	vaccine	vaccine	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	environmental	environmental	JJ	JJ	_	14	amod	_	_
14	mycobacteria	mycobacterium	NNS	NNS	_	11	conj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	humans	human	NNS	NNS	_	11	nmod	_	_
17	remains	remain	VBZ	VBZ	_	16	dep	_	_
18	largely	largely	RB	RB	_	19	advmod	_	_
19	unknown	unknown	JJ	JJ	_	3	amod	_	_
20	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	18	18	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	2	dobj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	several	several	JJ	JJ	_	7	amod	_	_
7	generations	generation	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	12	12	CD	CD	_	11	nummod	_	_
10	unrelated	unrelated	JJ	JJ	_	11	amod	_	_
11	families	family	NNS	NNS	_	7	nmod	_	_
12	who	who	WP	WP	_	14	nsubj	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	heterozygous	heterozygous	JJ	JJ	_	11	acl:relcl	_	_
15	for	for	IN	IN	_	23	case	_	_
16	1	1	CD	CD	_	18	compound	_	_
17	to	to	TO	TO	_	18	dep	_	_
18	5	5	CD	CD	_	23	nummod	_	_
19	overlapping	overlap	VBG	VBG	_	23	amod	_	_
20	IFNGR1	ifngr1	NN	NN	_	23	compound	_	_
21	frameshift	frameshift	NN	NN	_	23	compound	_	_
22	small	small	JJ	JJ	_	23	amod	_	_
23	deletions	deletion	NNS	NNS	_	14	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	a	a	DT	DT	_	28	det	_	_
26	wild-type	wild-type	JJ	JJ	_	28	amod	_	_
27	IFNGR1	ifngr1	NN	NN	_	28	compound	_	_
28	allele	allele	NN	NN	_	23	conj	_	_
29	.	.	.	.	_	2	punct	_	_

1	There	there	EX	EX	_	13	expl	_	_
2	were	be	VBD	VBD	_	13	cop	_	_
3	12	12	CD	CD	_	6	nummod	_	_
4	independent	independent	JJ	JJ	_	6	amod	_	_
5	mutation	mutation	NN	NN	_	6	compound	_	_
6	events	event	NNS	NNS	_	13	nsubj	_	_
7	at	at	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	dep	_	_
9	single	single	JJ	JJ	_	11	case	_	_
10	mutation	mutation	NN	NN	_	11	dep	_	_
11	site	site	NN	NN	_	13	advcl	_	_
12	,	,	,	,	_	13	punct	_	_
13	defining	define	VBG	VBG	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	small	small	JJ	JJ	_	17	amod	_	_
16	deletion	deletion	NN	NN	_	17	compound	_	_
17	hotspot	hotspot	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	13	punct	_	_

1	Neighbouring	neighbour	VBG	VBG	_	3	amod	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	favours	favour	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	small	small	JJ	JJ	_	8	amod	_	_
7	deletion	deletion	NN	NN	_	8	compound	_	_
8	model	model	NN	NN	_	4	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	slipped	slipped	JJ	JJ	_	12	amod	_	_
11	mispairing	mispairing	NN	NN	_	12	compound	_	_
12	events	event	NNS	NNS	_	8	nmod	_	_
13	during	during	IN	IN	_	14	case	_	_
14	replication	replication	NN	NN	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	mutant	mutant	JJ	JJ	_	3	amod	_	_
3	alleles	allele	NNS	NNS	_	4	nsubj	_	_
4	encode	encode	VBP	VBP	_	0	root	_	_
5	cell-surface	cell-surface	JJ	JJ	_	7	amod	_	_
6	IFNgamma	ifngamma	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	dobj	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	lack	lack	VBP	VBP	_	7	acl:relcl	_	_
10	the	the	DT	DT	_	12	det	_	_
11	intra-cytoplasmic	intra-cytoplasmic	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	4	punct	_	_
14	which	which	WDT	WDT	_	30	dep	_	_
15	,	,	,	,	_	30	punct	_	_
16	through	through	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	combination	combination	NN	NN	_	30	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	impaired	impaired	JJ	JJ	_	21	amod	_	_
21	recycling	recycling	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	30	punct	_	_
23	abrogated	abrogate	VBD	VBD	_	24	amod	_	_
24	signalling	signalling	NN	NN	_	30	nsubj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	normal	normal	JJ	JJ	_	27	amod	_	_
27	binding	binding	NN	NN	_	24	conj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	IFNgamma	ifngamma	NN	NN	_	27	nmod	_	_
30	exert	exert	VBP	VBP	_	4	dep	_	_
31	a	a	DT	DT	_	33	det	_	_
32	dominant-negative	dominant-negative	JJ	JJ	_	33	amod	_	_
33	effect	effect	NN	NN	_	30	dobj	_	_
34	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	thus	thus	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	hotspot	hotspot	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	IFNGR1	ifngr1	NN	NN	_	10	compound	_	_
9	small	small	JJ	JJ	_	10	amod	_	_
10	deletions	deletion	NNS	NNS	_	5	nmod	_	_
11	that	that	IN	IN	_	12	nsubj	_	_
12	confer	confer	VBP	VBP	_	5	acl:relcl	_	_
13	dominant	dominant	JJ	JJ	_	14	amod	_	_
14	susceptibility	susceptibility	NN	NN	_	12	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	infections	infection	NNS	NNS	_	14	nmod	_	_
17	caused	cause	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	21	case	_	_
19	poorly	poorly	RB	RB	_	21	advmod	_	_
20	virulent	virulent	JJ	JJ	_	21	amod	_	_
21	mycobacteria	mycobacterium	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Erythroid	erythroid	JJ	JJ	_	3	amod	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	differentially	differentially	RB	RB	_	6	advmod	_	_
6	regulated	regulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	erythropoietin	erythropoietin	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	haemin	haemin	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	delta-aminolaevulinic	delta-aminolaevulinic	JJ	JJ	_	13	amod	_	_
13	acid	acid	NN	NN	_	8	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	UT-7	ut-7	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Erythropoietin	erythropoietin	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Epo	epo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	essential	essential	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	later	later	JJR	JJR	_	10	amod	_	_
10	stages	stage	NNS	NNS	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	erythropoiesis	erythropoiesis	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	acting	act	VBG	VBG	_	6	xcomp	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	promote	promote	VB	VB	_	14	xcomp	_	_
17	cell	cell	NN	NN	_	16	dobj	_	_
18	survival	survival	NN	NN	_	17	dep	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	proliferation	proliferation	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	6	punct	_	_
22	but	but	CC	CC	_	6	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	role	role	NN	NN	_	27	nsubj	_	_
25	in	in	IN	IN	_	26	case	_	_
26	differentiation	differentiation	NN	NN	_	24	nmod	_	_
27	remains	remain	VBZ	VBZ	_	6	conj	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	defined	define	VBN	VBN	_	27	xcomp	_	_
31	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	UT-7	ut-7	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	line	line	NN	NN	_	5	nsubj	_	_
5	exhibits	exhibit	VBZ	VBZ	_	0	root	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	megakaryocytic	megakaryocytic	JJ	JJ	_	7	conj	_	_
10	characteristics	characteristic	NNS	NNS	_	5	dobj	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	induced	induce	VBN	VBN	_	5	conj	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	differentiate	differentiate	VB	VB	_	14	xcomp	_	_
17	along	along	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
20	pathway	pathway	NN	NN	_	16	nmod	_	_
21	by	by	IN	IN	_	22	case	_	_
22	Epo	epo	NN	NN	_	14	nmod	_	_
23	or	or	CC	CC	_	14	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	megakaryocytic	megakaryocytic	JJ	JJ	_	26	amod	_	_
26	pathway	pathway	NN	NN	_	14	conj	_	_
27	by	by	IN	IN	_	30	case	_	_
28	phorbol	phorbol	NN	NN	_	30	compound	_	_
29	myristic	myristic	JJ	JJ	_	30	amod	_	_
30	acetate	acetate	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	compared	compare	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Epo	epo	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	chemical	chemical	JJ	JJ	_	11	amod	_	_
11	inducers	inducer	NNS	NNS	_	7	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	delta-aminolaevulinic	delta-aminolaevulinic	JJ	JJ	_	14	amod	_	_
14	acid	acid	NN	NN	_	11	appos	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	delta-ALA	delta-ala	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	haemin	haemin	NN	NN	_	14	conj	_	_
20	on	on	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	differentiation	differentiation	NN	NN	_	23	compound	_	_
23	capacity	capacity	NN	NN	_	5	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	UT-7	ut-7	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Epo	epo	NN	NN	_	3	nsubj	_	_
2	alone	alone	RB	RB	_	1	advmod	_	_
3	promoted	promote	VBD	VBD	_	0	root	_	_
4	relatively	relatively	RB	RB	_	5	advmod	_	_
5	early	early	JJ	JJ	_	6	amod	_	_
6	events	event	NNS	NNS	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
9	maturation	maturation	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	without	without	IN	IN	_	13	case	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	changes	change	NNS	NNS	_	3	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	haemoglobin	haemoglobin	NN	NN	_	13	nmod	_	_
16	production	production	NN	NN	_	15	dep	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	morphology	morphology	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	GATA-2	gata-2	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	c-myb	c-myb	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	Epo	epo	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	GATA-2	gata-2	NN	NN	_	13	nsubjpass	_	_
11	was	be	VBD	VBD	_	13	auxpass	_	_
12	further	further	RB	RB	_	13	advmod	_	_
13	down-modulated	down-modulate	VBN	VBN	_	5	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	inducers	inducer	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Conversely	conversely	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	SCL	scl	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	case	_	_
8	Epo	epo	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	further	further	RB	RB	_	11	advmod	_	_
11	increased	increase	VBN	VBN	_	6	conj	_	_
12	by	by	IN	IN	_	13	case	_	_
13	haemin	haemin	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	delta-ALA	delta-ala	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	6	punct	_	_

1	Epo	epo	NN	NN	_	2	nsubj	_	_
2	caused	cause	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	proportion	proportion	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	expressing	express	VBG	VBG	_	9	acl	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	surface	surface	NN	NN	_	10	dobj	_	_
13	glycophorin	glycophorin	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	12	dep	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	GPA	gpa	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	2	cc	_	_
19	up-regulated	up-regulate	VBD	VBD	_	2	conj	_	_
20	beta-	beta-	NN	NN	_	19	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	gamma-globin	gamma-globin	NN	NN	_	20	conj	_	_
23	by	by	IN	IN	_	25	case	_	_
24	several	several	JJ	JJ	_	25	amod	_	_
25	fold	fold	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	haemin	haemin	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	delta-ALA	delta-ala	NN	NN	_	2	conj	_	_
5	caused	cause	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	de	de	FW	FW	_	9	amod	_	_
8	novo	novo	FW	FW	_	7	dep	_	_
9	increase	increase	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	alpha-globin	alpha-globin	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	enhancing	enhance	VBG	VBG	_	17	dep	_	_
17	Epo-induced	epo-induced	JJ	JJ	_	19	amod	_	_
18	beta-globin	beta-globin	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	12	conj	_	_
20	,	,	,	,	_	9	punct	_	_
21	leading	lead	VBG	VBG	_	9	acl	_	_
22	to	to	TO	TO	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	marked	marked	JJ	JJ	_	25	amod	_	_
25	increase	increase	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	haemoglobin	haemoglobin	NN	NN	_	28	compound	_	_
28	production	production	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	haemoglobin	haemoglobin	NN	NN	_	6	compound	_	_
6	production	production	NN	NN	_	11	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	UT-7	ut-7	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	limited	limit	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	deficiency	deficiency	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	23	case	_	_
16	erythroid-specific	erythroid-specific	JJ	JJ	_	19	amod	_	_
17	aminolaevulinic	aminolaevulinic	JJ	JJ	_	19	amod	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	synthase	synthase	NN	NN	_	23	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ALAS-E	alas-e	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	activity	activity	NN	NN	_	14	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	globin	globin	NN	NN	_	26	compound	_	_
26	synthesis	synthesis	NN	NN	_	23	conj	_	_
27	as	as	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	consequence	consequence	NN	NN	_	14	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
32	immaturity	immaturity	NN	NN	_	29	nmod	_	_
33	as	as	IN	IN	_	37	case	_	_
34	a	a	DT	DT	_	37	det	_	_
35	multipotential	multipotential	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	line	line	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Evidence	evidence	NN	NN	_	0	root	_	_
2	for	for	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	polyclonal	polyclonal	JJ	JJ	_	5	amod	_	_
5	etiology	etiology	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	palmar	palmar	JJ	JJ	_	8	amod	_	_
8	fibromatosis	fibromatosis	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	1	punct	_	_

1	X	x	NN	NN	_	4	compound	_	_
2	chromosome	chromosome	NN	NN	_	4	compound	_	_
3	inactivation	inactivation	NN	NN	_	4	compound	_	_
4	patterns	pattern	NNS	NNS	_	11	nsubjpass	_	_
5	at	at	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	androgen	androgen	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	locus	locus	NN	NN	_	4	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	evaluated	evaluate	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	determine	determine	VB	VB	_	11	xcomp	_	_
14	clonality	clonality	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	microdissected	microdissected	JJ	JJ	_	18	amod	_	_
17	lesional	lesional	JJ	JJ	_	18	amod	_	_
18	tissue	tissue	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	21	case	_	_
21	leukocytes	leukocyte	NNS	NNS	_	18	conj	_	_
22	from	from	IN	IN	_	24	case	_	_
23	2	2	CD	CD	_	24	nummod	_	_
24	women	woman	NNS	NNS	_	21	nmod	_	_
25	with	with	IN	IN	_	28	case	_	_
26	Dupuytren	dupuytren	NN	NN	_	28	nmod:poss	_	_
27	's	's	POS	POS	_	26	case	_	_
28	disease	disease	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	tissue	tissue	NN	NN	_	6	nsubj	_	_
3	from	from	IN	IN	_	5	case	_	_
4	both	both	DT	DT	_	5	det	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	generated	generate	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	polyclonal	polyclonal	JJ	JJ	_	9	amod	_	_
9	pattern	pattern	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	X	x	NN	NN	_	13	compound	_	_
12	chromosome	chromosome	NN	NN	_	13	compound	_	_
13	inactivation	inactivation	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	androgen	androgen	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	3	nsubj	_	_
3	supports	support	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	polyclonal	polyclonal	JJ	JJ	_	7	amod	_	_
6	reactive	reactive	JJ	JJ	_	7	amod	_	_
7	process	process	NN	NN	_	3	dobj	_	_
8	as	as	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	underlying	underlying	JJ	JJ	_	11	amod	_	_
11	etiology	etiology	NN	NN	_	3	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	palmar	palmar	JJ	JJ	_	14	amod	_	_
14	fibromatosis	fibromatosis	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	9	case	_	_
5	Mycobacterium	mycobacterium	NN	NN	_	6	nmod:npmod	_	_
6	tuberculosis-induced	tuberculosis-induced	JJ	JJ	_	9	amod	_	_
7	interleukin-2	interleukin-2	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	1	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	phagocytes	phagocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Soluble	soluble	JJ	JJ	_	3	amod	_	_
2	interleukin-2	interleukin-2	NN	NN	_	3	compound	_	_
3	receptor-alpha	receptor-alpha	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL-2Ralpha	il-2ralpha	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	reported	report	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	increased	increase	VBN	VBN	_	9	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	sera	serum	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	advanced	advanced	JJ	JJ	_	20	amod	_	_
20	tuberculosis	tuberculosis	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	levels	level	NNS	NNS	_	24	nsubj	_	_
24	decline	decline	VBP	VBP	_	9	conj	_	_
25	after	after	IN	IN	_	26	case	_	_
26	therapy	therapy	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	accordance	accordance	NN	NN	_	30	dep	_	_
29	with	with	IN	IN	_	30	case	_	_
30	improvement	improvement	NN	NN	_	24	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	radiologic	radiologic	JJ	JJ	_	33	amod	_	_
33	findings	finding	NNS	NNS	_	30	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	IL-2Ralpha	il-2ralpha	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	13	case	_	_
8	bronchoalveolar	bronchoalveolar	JJ	JJ	_	13	amod	_	_
9	lavage	lavage	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	BAL	bal	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	cells	cell	NNS	NNS	_	6	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	active	active	JJ	JJ	_	17	amod	_	_
16	pulmonary	pulmonary	JJ	JJ	_	17	amod	_	_
17	tuberculosis	tuberculosis	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	and	and	CC	CC	_	2	cc	_	_
20	evaluated	evaluate	VBD	VBD	_	2	conj	_	_
21	the	the	DT	DT	_	22	det	_	_
22	mechanism	mechanism	NN	NN	_	20	dobj	_	_
23	Mycobacterium	mycobacterium	NN	NN	_	24	compound	_	_
24	tuberculosis	tuberculosis	NN	NN	_	25	dep	_	_
25	induces	induce	VBZ	VBZ	_	22	dep	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	IL-2Ralpha	il-2ralpha	NN	NN	_	25	nmod	_	_
29	using	use	VBG	VBG	_	20	xcomp	_	_
30	the	the	DT	DT	_	35	det	_	_
31	THP-1	thp-1	NN	NN	_	35	compound	_	_
32	mononuclear	mononuclear	JJ	JJ	_	35	amod	_	_
33	phagocyte	phagocyte	NN	NN	_	35	compound	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	line	line	NN	NN	_	29	dobj	_	_
36	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	IL-2Ralpha	il-2ralpha	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	to	to	TO	TO	_	7	mark	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	increased	increase	VBN	VBN	_	2	xcomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	BAL	bal	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	from	from	IN	IN	_	13	case	_	_
12	involved	involve	VBN	VBN	_	13	amod	_	_
13	sites	site	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	active	active	JJ	JJ	_	17	amod	_	_
16	pulmonary	pulmonary	JJ	JJ	_	17	amod	_	_
17	tuberculosis	tuberculosis	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	15	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	alpha-chain	alpha-chain	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-2Ralpha	il-2ralpha	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PBM	pbm	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	18	case	_	_
17	M.	m.	NN	NN	_	18	compound	_	_
18	tuberculosis	tuberculosis	NN	NN	_	15	nmod	_	_
19	by	by	IN	IN	_	22	case	_	_
20	flow	flow	NN	NN	_	22	compound	_	_
21	cytometry	cytometry	NN	NN	_	22	compound	_	_
22	evaluation	evaluation	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	15	punct	_	_

1	Northern	northern	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	increased	increase	VBN	VBN	_	7	amod	_	_
5	IL-2Ralpha	il-2ralpha	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	dobj	_	_
8	after	after	IN	IN	_	9	case	_	_
9	stimulation	stimulation	NN	NN	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	M.	m.	NN	NN	_	12	compound	_	_
12	tuberculosis	tuberculosis	NN	NN	_	9	nmod	_	_
13	which	which	WDT	WDT	_	16	nsubjpass	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	further	further	RBR	RBR	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	7	acl:relcl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	interferon-gamma	interferon-gamma	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	IL-2Ralpha	il-2ralpha	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	16	nsubjpass	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	13	det	_	_
6	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
7	factor	factor	NN	NN	_	13	compound	_	_
8	kappa	kappa	NN	NN	_	13	compound	_	_
9	B	b	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	site	site	NN	NN	_	4	dobj	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	transcriptionally	transcriptionally	RB	RB	_	16	advmod	_	_
16	induced	induce	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	19	case	_	_
18	M.	m.	NN	NN	_	19	compound	_	_
19	tuberculosis	tuberculosis	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	this	this	DT	DT	_	23	det	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	25	nsubj	_	_
24	could	could	MD	MD	_	25	aux	_	_
25	confer	confer	VB	VB	_	16	conj	_	_
26	inducibility	inducibility	NN	NN	_	25	dobj	_	_
27	to	to	TO	TO	_	36	case	_	_
28	a	a	DT	DT	_	36	det	_	_
29	heterologous	heterologous	JJ	JJ	_	36	amod	_	_
30	herpes	herpes	NN	NN	_	36	compound	_	_
31	thymidine	thymidine	NN	NN	_	36	compound	_	_
32	kinase	kinase	NN	NN	_	36	compound	_	_
33	(	(	-LRB-	-LRB-	_	36	punct	_	_
34	TK	tk	NN	NN	_	36	compound	_	_
35	)	)	-RRB-	-RRB-	_	36	punct	_	_
36	promoter	promoter	NN	NN	_	25	nmod	_	_
37	by	by	IN	IN	_	39	case	_	_
38	M.	m.	NN	NN	_	39	compound	_	_
39	tuberculosis	tuberculosis	NN	NN	_	25	nmod	_	_
40	.	.	.	.	_	16	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSAs	emsa	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	revealed	reveal	VBD	VBD	_	0	root	_	_
9	specific	specific	JJ	JJ	_	10	amod	_	_
10	binding	binding	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	10	nmod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	10	nmod	_	_
18	upon	upon	IN	IN	_	19	case	_	_
19	induction	induction	NN	NN	_	10	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	M.	m.	NN	NN	_	22	compound	_	_
22	tuberculosis	tuberculosis	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	Using	use	VBG	VBG	_	24	advcl	_	_
2	antibodies	antibody	NNS	NNS	_	1	dobj	_	_
3	against	against	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	p50	p50	NN	NN	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	p65	p65	NN	NN	_	5	conj	_	_
8	subunits	subunit	NNS	NNS	_	1	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	EMSAs	emsa	NNS	NNS	_	1	nmod	_	_
13	,	,	,	,	_	24	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	involvement	involvement	NN	NN	_	24	nsubjpass	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	p50	p50	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	p65	p65	NN	NN	_	21	compound	_	_
21	proteins	protein	NNS	NNS	_	18	conj	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	further	further	RBR	RBR	_	24	advmod	_	_
24	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
25	.	.	.	.	_	24	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	IL-2Ralpha	il-2ralpha	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	phagocytes	phagocyte	NNS	NNS	_	2	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	M.	m.	NN	NN	_	12	compound	_	_
11	tuberculosis	tuberculosis	NN	NN	_	12	compound	_	_
12	infection	infection	NN	NN	_	2	nmod	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	play	play	VB	VB	_	0	root	_	_
15	an	a	DT	DT	_	18	det	_	_
16	important	important	JJ	JJ	_	18	amod	_	_
17	immunomodulatory	immunomodulatory	JJ	JJ	_	18	amod	_	_
18	role	role	NN	NN	_	14	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	host	host	NN	NN	_	22	compound	_	_
22	response	response	NN	NN	_	14	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	megakaryocytic	megakaryocytic	JJ	JJ	_	7	amod	_	_
5	glycoprotein	glycoprotein	NN	NN	_	7	compound	_	_
6	IX	ix	CD	CD	_	7	nummod	_	_
7	promoter	promoter	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	14	case	_	_
9	the	the	DT	DT	_	14	det	_	_
10	oncogenic	oncogenic	JJ	JJ	_	14	amod	_	_
11	Ets	ets	NN	NN	_	14	compound	_	_
12	transcription	transcription	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	Fli-1	fli-1	NN	NN	_	1	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Glycoprotein	glycoprotein	NN	NN	_	3	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GP	gp	NN	NN	_	8	nsubj	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	IX	ix	CD	CD	_	3	nummod	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	a	a	DT	DT	_	8	det	_	_
8	subunit	subunit	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	von	von	NN	NN	_	13	compound	_	_
12	Willebrand	willebrand	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	GPIb-V-IX	gpib-v-ix	NN	NN	_	13	appos	_	_
16	,	,	,	,	_	13	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	mediates	mediate	VBZ	VBZ	_	13	acl:relcl	_	_
19	adhesion	adhesion	NN	NN	_	18	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	platelets	platelet	NNS	NNS	_	19	nmod	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	subendothelium	subendothelium	NN	NN	_	19	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	damaged	damage	VBN	VBN	_	28	amod	_	_
27	blood	blood	NN	NN	_	28	compound	_	_
28	vessels	vessel	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	characterization	characterization	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	GPIX	gpix	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	11	det	_	_
9	functional	functional	JJ	JJ	_	11	amod	_	_
10	Ets	ets	NN	NN	_	11	compound	_	_
11	site	site	NN	NN	_	7	dobj	_	_
12	that	that	WDT	WDT	_	17	dep	_	_
13	,	,	,	,	_	17	punct	_	_
14	when	when	WRB	WRB	_	15	advmod	_	_
15	disrupted	disrupt	VBN	VBN	_	17	advcl	_	_
16	,	,	,	,	_	17	punct	_	_
17	reduced	reduce	VBD	VBD	_	11	acl:relcl	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	7	det	_	_
4	Ets	ets	NN	NN	_	7	compound	_	_
5	protein	protein	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	s	s	NNS	NNS	_	15	nsubj	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	regulated	regulate	VBD	VBD	_	7	acl:relcl	_	_
11	GPIX	gpix	NN	NN	_	13	compound	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	unknown	unknown	JJ	JJ	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	21	nmod	_	_
4	,	,	,	,	_	21	punct	_	_
5	transient	transient	JJ	JJ	_	6	amod	_	_
6	cotransfection	cotransfection	NN	NN	_	21	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	several	several	JJ	JJ	_	11	amod	_	_
9	GPIX	gpix	NN	NN	_	11	compound	_	_
10	promoter/reporter	promoter/reporter	NN	NN	_	11	compound	_	_
11	constructs	construct	NNS	NNS	_	6	nmod	_	_
12	into	into	IN	IN	_	15	case	_	_
13	293T	293t	NN	NN	_	15	compound	_	_
14	kidney	kidney	NN	NN	_	15	compound	_	_
15	fibroblasts	fibroblast	NNS	NNS	_	6	nmod	_	_
16	with	with	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	Fli-1	fli-1	NN	NN	_	20	compound	_	_
19	expression	expression	NN	NN	_	20	compound	_	_
20	vector	vector	NN	NN	_	15	nmod	_	_
21	shows	show	VBZ	VBZ	_	0	root	_	_
22	that	that	IN	IN	_	28	mark	_	_
23	the	the	DT	DT	_	26	det	_	_
24	oncogenic	oncogenic	JJ	JJ	_	26	amod	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	Fli-1	fli-1	NN	NN	_	28	nsubj	_	_
27	can	can	MD	MD	_	28	aux	_	_
28	transactivate	transactivate	VB	VB	_	21	ccomp	_	_
29	the	the	DT	DT	_	31	det	_	_
30	GPIX	gpix	NN	NN	_	31	compound	_	_
31	promoter	promoter	NN	NN	_	28	dobj	_	_
32	when	when	WRB	WRB	_	39	advmod	_	_
33	an	a	DT	DT	_	37	det	_	_
34	intact	intact	JJ	JJ	_	37	amod	_	_
35	GPIX	gpix	NN	NN	_	37	compound	_	_
36	Ets	ets	NN	NN	_	37	compound	_	_
37	site	site	NN	NN	_	39	nsubj	_	_
38	is	be	VBZ	VBZ	_	39	cop	_	_
39	present	present	JJ	JJ	_	28	advcl	_	_
40	.	.	.	.	_	21	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	Fli-1	fli-1	NN	NN	_	5	compound	_	_
5	binding	binding	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	GPIX	gpix	NN	NN	_	10	compound	_	_
9	Ets	ets	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	antibody	antibody	NN	NN	_	16	compound	_	_
15	supershift	supershift	NN	NN	_	16	compound	_	_
16	experiments	experiment	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
19	extracts	extract	NNS	NNS	_	12	nmod	_	_
20	derived	derive	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	25	case	_	_
22	hematopoietic	hematopoietic	JJ	JJ	_	25	amod	_	_
23	human	human	JJ	JJ	_	25	amod	_	_
24	erythroleukemia	erythroleukemia	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	12	punct	_	_

1	Comparative	comparative	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	Fli-1	fli-1	NN	NN	_	8	nsubj	_	_
6	was	be	VBD	VBD	_	8	cop	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	able	able	JJ	JJ	_	3	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	transactivate	transactivate	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	12	det	_	_
12	GPIbalpha	gpibalpha	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	,	,	,	,	_	10	punct	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	lesser	lesser	JJR	JJR	_	18	amod	_	_
18	extent	extent	NN	NN	_	22	nmod	_	_
19	,	,	,	,	_	22	punct	_	_
20	the	the	DT	DT	_	22	det	_	_
21	GPIIb	gpiib	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	10	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Immunoblot	immunoblot	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	Fli-1	fli-1	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	lysates	lysate	NNS	NNS	_	3	nmod	_	_
8	derived	derive	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	10	case	_	_
10	platelets	platelet	NNS	NNS	_	8	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	expression	expression	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Fli-1	fli-1	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	immunohistochemically	immunohistochemically	RB	RB	_	8	advmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	megakaryocytes	megakaryocyte	NNS	NNS	_	8	nmod	_	_
12	derived	derive	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	CD34(+)	cd34(+)	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	treated	treat	VBN	VBN	_	15	acl	_	_
17	with	with	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	megakaryocyte	megakaryocyte	NN	NN	_	20	compound	_	_
20	differentiation	differentiation	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	proliferation	proliferation	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	20	conj	_	_
24	,	,	,	,	_	20	punct	_	_
25	thrombopoietin	thrombopoietin	NN	NN	_	20	appos	_	_
26	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Fli-1	fli-1	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	likely	likely	JJ	JJ	_	3	ccomp	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	regulate	regulate	VB	VB	_	7	xcomp	_	_
10	lineage-specific	lineage-specific	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	9	dobj	_	_
12	during	during	IN	IN	_	13	case	_	_
13	megakaryocytopoiesis	megakaryocytopoiesis	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	pseudo-hypoaldosteronism	pseudo-hypoaldosteronism	NN	NN	_	0	root	_	_
3	following	follow	VBG	VBG	_	4	case	_	_
4	resection	resection	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	ileum	ileum	NN	NN	_	4	nmod	_	_
8	:	:	:	:	_	2	punct	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	level	level	NN	NN	_	2	dep	_	_
11	of	of	IN	IN	_	14	case	_	_
12	lymphocytic	lymphocytic	JJ	JJ	_	14	amod	_	_
13	aldosterone	aldosterone	NN	NN	_	14	compound	_	_
14	receptors	receptor	NNS	NNS	_	10	nmod	_	_
15	outside	outside	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	acute	acute	JJ	JJ	_	18	amod	_	_
18	phase	phase	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Pseudo-hypoaldosteronism	pseudo-hypoaldosteronism	NN	NN	_	9	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	PHA	pha	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	due	due	JJ	JJ	_	9	case	_	_
7	to	to	TO	TO	_	6	mwe	_	_
8	mineralocorticoid	mineralocorticoid	NN	NN	_	9	compound	_	_
9	resistance	resistance	NN	NN	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	manifests	manifest	VBZ	VBZ	_	9	conj	_	_
12	as	as	IN	IN	_	13	case	_	_
13	hyponatremia	hyponatremia	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	hyperkalemia	hyperkalemia	NN	NN	_	13	conj	_	_
16	with	with	IN	IN	_	20	case	_	_
17	increased	increase	VBN	VBN	_	20	amod	_	_
18	plasma	plasma	NN	NN	_	20	compound	_	_
19	aldosterone	aldosterone	NN	NN	_	20	compound	_	_
20	levels	level	NNS	NNS	_	13	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	may	may	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	cop	_	_
4	familial	familial	JJ	JJ	_	0	root	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	secondary	secondary	JJ	JJ	_	4	conj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	abnormal	abnormal	JJ	JJ	_	11	amod	_	_
9	renal	renal	JJ	JJ	_	11	amod	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	handling	handling	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	case	case	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	54-year-old	54-year-old	JJ	JJ	_	8	amod	_	_
8	woman	woman	NN	NN	_	4	nmod	_	_
9	with	with	IN	IN	_	11	case	_	_
10	multifocal	multifocal	JJ	JJ	_	11	amod	_	_
11	cancer	cancer	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	colon	colon	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	who	who	WP	WP	_	17	nsubj	_	_
17	developed	develop	VBD	VBD	_	8	acl:relcl	_	_
18	PHA	pha	NN	NN	_	17	dobj	_	_
19	after	after	IN	IN	_	21	case	_	_
20	subtotal	subtotal	JJ	JJ	_	21	amod	_	_
21	colectomy	colectomy	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	ileal	ileal	JJ	JJ	_	24	amod	_	_
24	resection	resection	NN	NN	_	21	conj	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	jejunostomy	jejunostomy	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	She	she	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	treated	treat	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	6	6	CD	CD	_	6	nummod	_	_
6	g	g	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	salt	salt	NN	NN	_	6	nmod	_	_
9	daily	daily	RB	RB	_	3	advmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	prevent	prevent	VB	VB	_	3	xcomp	_	_
12	dehydration	dehydration	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	which	which	WDT	WDT	_	16	dobj	_	_
15	she	she	PRP	PRP	_	16	nsubj	_	_
16	stopped	stop	VBD	VBD	_	12	acl:relcl	_	_
17	herself	herself	PRP	PRP	_	16	dobj	_	_
18	because	because	IN	IN	_	22	case	_	_
19	of	of	IN	IN	_	18	mwe	_	_
20	reduced	reduce	VBN	VBN	_	22	amod	_	_
21	fecal	fecal	JJ	JJ	_	22	amod	_	_
22	losses	loss	NNS	NNS	_	16	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	month	month	NN	NN	_	3	nmod:npmod	_	_
3	later	later	RB	RB	_	6	advmod	_	_
4	she	she	PRP	PRP	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	admitted	admit	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	8	case	_	_
8	signs	sign	NNS	NNS	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	adrenal	adrenal	JJ	JJ	_	12	amod	_	_
12	failure	failure	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	i.e.	i.e.	FW	FW	_	15	advmod	_	_
15	fatigue	fatigue	NN	NN	_	8	appos	_	_
16	,	,	,	,	_	15	punct	_	_
17	severe	severe	JJ	JJ	_	18	amod	_	_
18	nausea	nausea	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	blood	blood	NN	NN	_	21	compound	_	_
21	pressure	pressure	NN	NN	_	15	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	80/60	80/60	CD	CD	_	24	nummod	_	_
24	mmHg	mmhg	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	15	punct	_	_
26	extracellular	extracellular	JJ	JJ	_	27	amod	_	_
27	dehydration	dehydration	NN	NN	_	15	conj	_	_
28	,	,	,	,	_	15	punct	_	_
29	hyponatremia	hyponatremia	NN	NN	_	15	conj	_	_
30	(	(	-LRB-	-LRB-	_	32	punct	_	_
31	118	118	CD	CD	_	32	nummod	_	_
32	mmol/l	mmol/l	NN	NN	_	29	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	;	;	:	:	_	15	punct	_	_
35	hyperkalemia	hyperkalemia	NN	NN	_	15	conj	_	_
36	(	(	-LRB-	-LRB-	_	38	punct	_	_
37	7.6	7.6	CD	CD	_	38	nummod	_	_
38	mmol/l	mmol/l	NN	NN	_	35	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	,	,	,	,	_	15	punct	_	_
41	increased	increase	VBN	VBN	_	44	amod	_	_
42	blood	blood	NN	NN	_	44	compound	_	_
43	urea	urea	NN	NN	_	44	compound	_	_
44	nitrogen	nitrogen	NN	NN	_	15	conj	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	BUN	bun	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	(	(	-LRB-	-LRB-	_	50	punct	_	_
49	200	200	CD	CD	_	50	nummod	_	_
50	mg/dl	mg/dl	NN	NN	_	44	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	and	and	CC	CC	_	44	cc	_	_
53	creatininemia	creatininemia	NN	NN	_	44	conj	_	_
54	(	(	-LRB-	-LRB-	_	56	punct	_	_
55	2.5	2.5	CD	CD	_	56	nummod	_	_
56	mg/dl	mg/dl	NN	NN	_	53	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	,	,	,	,	_	15	punct	_	_
59	and	and	CC	CC	_	15	cc	_	_
60	decreased	decrease	VBN	VBN	_	63	amod	_	_
61	plasma	plasma	NN	NN	_	63	compound	_	_
62	bicarbonates	bicarbonate	NNS	NNS	_	63	compound	_	_
63	level	level	NN	NN	_	15	conj	_	_
64	(	(	-LRB-	-LRB-	_	68	punct	_	_
65	HCO3-	hco3-	JJ	JJ	_	68	dep	_	_
66	:	:	:	:	_	68	punct	_	_
67	16	16	CD	CD	_	68	nummod	_	_
68	mmol/l	mmol/l	NN	NN	_	63	dep	_	_
69	;	;	:	:	_	68	punct	_	_
70	N	n	NN	NN	_	72	dep	_	_
71	:	:	:	:	_	72	punct	_	_
72	27-30	27-30	CD	CD	_	68	parataxis	_	_
73	)	)	-RRB-	-RRB-	_	68	punct	_	_
74	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	plasma	plasma	NN	NN	_	5	compound	_	_
5	cortisol	cortisol	NN	NN	_	7	nsubj	_	_
6	was	be	VBD	VBD	_	7	cop	_	_
7	high	high	JJ	JJ	_	0	root	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	66	66	CD	CD	_	11	nummod	_	_
10	microg/100	microg/100	NN	NN	_	11	compound	_	_
11	ml	ml	NN	NN	_	7	dep	_	_
12	at	at	IN	IN	_	14	case	_	_
13	10:00	10:00	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	11	nmod	_	_
15	;	;	:	:	_	11	punct	_	_
16	N	n	NN	NN	_	18	dep	_	_
17	:	:	:	:	_	18	punct	_	_
18	8-15	8-15	CD	CD	_	11	dep	_	_
19	)	)	-RRB-	-RRB-	_	11	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	ACTH	acth	NN	NN	_	24	nsubj	_	_
23	was	be	VBD	VBD	_	24	cop	_	_
24	normal	normal	JJ	JJ	_	7	conj	_	_
25	(	(	-LRB-	-LRB-	_	27	punct	_	_
26	13	13	CD	CD	_	27	nummod	_	_
27	pg/ml	pg/ml	NN	NN	_	24	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	N	n	NN	NN	_	31	dep	_	_
30	:	:	:	:	_	31	punct	_	_
31	10-60	10-60	CD	CD	_	27	dep	_	_
32	)	)	-RRB-	-RRB-	_	27	punct	_	_
33	;	;	:	:	_	7	punct	_	_
34	there	there	EX	EX	_	35	expl	_	_
35	was	be	VBD	VBD	_	7	parataxis	_	_
36	a	a	DT	DT	_	38	det	_	_
37	marked	marked	JJ	JJ	_	38	amod	_	_
38	increase	increase	NN	NN	_	35	nsubj	_	_
39	in	in	IN	IN	_	42	case	_	_
40	plasma	plasma	NN	NN	_	42	compound	_	_
41	renin	renin	NN	NN	_	42	compound	_	_
42	activity	activity	NN	NN	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	46	punct	_	_
44	&gt;	&gt;	JJR	JJR	_	45	advmod	_	_
45	37	37	CD	CD	_	46	nummod	_	_
46	ng/ml/h	ng/ml/h	NN	NN	_	42	dep	_	_
47	;	;	:	:	_	46	punct	_	_
48	N	n	NN	NN	_	49	compound	_	_
49	supine	supine	NN	NN	_	51	dep	_	_
50	&lt;	&lt;	JJR	JJR	_	51	advmod	_	_
51	3	3	CD	CD	_	46	dep	_	_
52	)	)	-RRB-	-RRB-	_	46	punct	_	_
53	,	,	,	,	_	42	punct	_	_
54	active	active	JJ	JJ	_	55	amod	_	_
55	renin	renin	NN	NN	_	42	conj	_	_
56	(	(	-LRB-	-LRB-	_	58	punct	_	_
57	869	869	CD	CD	_	58	nummod	_	_
58	pg/ml	pg/ml	NN	NN	_	55	dep	_	_
59	;	;	:	:	_	58	punct	_	_
60	N	n	NN	NN	_	61	compound	_	_
61	supine	supine	NN	NN	_	63	dep	_	_
62	:	:	:	:	_	63	punct	_	_
63	1.120	1.120	CD	CD	_	58	dep	_	_
64	)	)	-RRB-	-RRB-	_	58	punct	_	_
65	,	,	,	,	_	42	punct	_	_
66	aldosterone	aldosterone	NN	NN	_	42	conj	_	_
67	(	(	-LRB-	-LRB-	_	70	punct	_	_
68	&gt;	&gt;	JJR	JJR	_	69	advmod	_	_
69	2000	2000	CD	CD	_	70	nummod	_	_
70	pg/ml	pg/ml	NN	NN	_	66	dep	_	_
71	;	;	:	:	_	70	punct	_	_
72	N	n	NN	NN	_	73	compound	_	_
73	supine	supine	NN	NN	_	75	dep	_	_
74	&lt;	&lt;	JJR	JJR	_	75	advmod	_	_
75	150	150	CD	CD	_	70	dep	_	_
76	)	)	-RRB-	-RRB-	_	70	punct	_	_
77	and	and	CC	CC	_	42	cc	_	_
78	plasma	plasma	NN	NN	_	79	compound	_	_
79	AVP	avp	NN	NN	_	42	conj	_	_
80	(	(	-LRB-	-LRB-	_	82	punct	_	_
81	20	20	CD	CD	_	82	nummod	_	_
82	pmol/l	pmol/l	NN	NN	_	79	dep	_	_
83	;	;	:	:	_	82	punct	_	_
84	N	n	NN	NN	_	86	dep	_	_
85	:	:	:	:	_	86	punct	_	_
86	0.5-2.5	0.5-2.5	CD	CD	_	82	dep	_	_
87	)	)	-RRB-	-RRB-	_	82	punct	_	_
88	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	plasma	plasma	NN	NN	_	4	compound	_	_
3	ANH	anh	NN	NN	_	4	compound	_	_
4	level	level	NN	NN	_	7	nsubj	_	_
5	was	be	VBD	VBD	_	7	cop	_	_
6	38	38	CD	CD	_	7	nummod	_	_
7	pmol/l	pmol/l	NN	NN	_	0	root	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	N	n	NN	NN	_	10	compound	_	_
10	supine	supine	NN	NN	_	12	dep	_	_
11	:	:	:	:	_	12	punct	_	_
12	5-25	5-25	CD	CD	_	7	parataxis	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	urinary	urinary	JJ	JJ	_	3	amod	_	_
3	steroidogram	steroidogram	NN	NN	_	4	nsubj	_	_
4	resulted	result	VBD	VBD	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	highly	highly	RB	RB	_	7	advmod	_	_
7	elevated	elevated	JJ	JJ	_	8	amod	_	_
8	tetrahydrocortisol	tetrahydrocortisol	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	THF	thf	NN	NN	_	13	dep	_	_
11	:	:	:	:	_	13	punct	_	_
12	13.3	13.3	CD	CD	_	13	nummod	_	_
13	mg/24h	mg/24h	NN	NN	_	8	dep	_	_
14	;	;	:	:	_	13	punct	_	_
15	N	n	NN	NN	_	17	dep	_	_
16	:	:	:	:	_	17	punct	_	_
17	1.4+/-0.8	1.4+/-0.8	CD	CD	_	13	parataxis	_	_
18	)	)	-RRB-	-RRB-	_	13	punct	_	_
19	with	with	IN	IN	_	21	case	_	_
20	no	no	DT	DT	_	21	neg	_	_
21	increase	increase	NN	NN	_	4	nmod	_	_
22	in	in	IN	IN	_	34	case	_	_
23	tetrahydrocortisone	tetrahydrocortisone	NN	NN	_	34	compound	_	_
24	(	(	-LRB-	-LRB-	_	28	punct	_	_
25	THE	the	DT	DT	_	28	dep	_	_
26	:	:	:	:	_	28	punct	_	_
27	3.16	3.16	CD	CD	_	28	nummod	_	_
28	mg/24h	mg/24h	NN	NN	_	34	dep	_	_
29	;	;	:	:	_	28	punct	_	_
30	N	n	NN	NN	_	32	dep	_	_
31	:	:	:	:	_	32	punct	_	_
32	2.7+/-2.0	2.7+/-2.0	CD	CD	_	28	parataxis	_	_
33	)	)	-RRB-	-RRB-	_	28	punct	_	_
34	excretion	excretion	NN	NN	_	21	nmod	_	_
35	,	,	,	,	_	21	punct	_	_
36	and	and	CC	CC	_	21	cc	_	_
37	with	with	IN	IN	_	39	case	_	_
38	low	low	JJ	JJ	_	39	amod	_	_
39	THE/THF	the/thf	NN	NN	_	21	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	0.24	0.24	CD	CD	_	39	dep	_	_
42	;	;	:	:	_	41	punct	_	_
43	N	n	NN	NN	_	45	dep	_	_
44	:	:	:	:	_	45	punct	_	_
45	1.87+/-0.36	1.87+/-0.36	CD	CD	_	41	dep	_	_
46	)	)	-RRB-	-RRB-	_	41	punct	_	_
47	and	and	CC	CC	_	39	cc	_	_
48	alpha	alpha	NN	NN	_	49	compound	_	_
49	THF/THF	thf/thf	NN	NN	_	39	conj	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	0.35	0.35	CD	CD	_	49	dep	_	_
52	;	;	:	:	_	51	punct	_	_
53	N	n	NN	NN	_	55	dep	_	_
54	:	:	:	:	_	55	punct	_	_
55	0.92+/-0.42	0.92+/-0.42	CD	CD	_	51	dep	_	_
56	)	)	-RRB-	-RRB-	_	51	punct	_	_
57	ratios	ratio	NNS	NNS	_	39	dep	_	_
58	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	number	number	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	mineralocorticoid	mineralocorticoid	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	leukocytes	leukocyte	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	14	cop	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	lower	lower	JJR	JJR	_	13	dep	_	_
13	normal	normal	JJ	JJ	_	14	amod	_	_
14	range	range	NN	NN	_	0	root	_	_
15	for	for	IN	IN	_	16	case	_	_
16	age	age	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	while	while	IN	IN	_	25	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	number	number	NN	NN	_	25	nsubjpass	_	_
21	of	of	IN	IN	_	23	case	_	_
22	glucocorticoid	glucocorticoid	NN	NN	_	23	compound	_	_
23	receptors	receptor	NNS	NNS	_	20	nmod	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	reduced	reduce	VBN	VBN	_	14	advcl	_	_
26	.	.	.	.	_	14	punct	_	_

1	Small-bowel	small-bowel	JJ	JJ	_	2	amod	_	_
2	resection	resection	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	ileostomized	ileostomized	JJ	JJ	_	5	amod	_	_
5	patients	patient	NNS	NNS	_	2	nmod	_	_
6	causes	cause	VBZ	VBZ	_	0	root	_	_
7	excessive	excessive	JJ	JJ	_	10	amod	_	_
8	fecal	fecal	JJ	JJ	_	10	amod	_	_
9	sodium	sodium	NN	NN	_	10	compound	_	_
10	losses	loss	NNS	NNS	_	6	dobj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	results	result	VBZ	VBZ	_	6	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	chronic	chronic	JJ	JJ	_	16	amod	_	_
15	sodium	sodium	NN	NN	_	16	compound	_	_
16	depletion	depletion	NN	NN	_	12	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	contraction	contraction	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	plasma	plasma	NN	NN	_	22	compound	_	_
22	volume	volume	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	severe	severe	JJ	JJ	_	26	amod	_	_
25	secondary	secondary	JJ	JJ	_	26	amod	_	_
26	hyperaldosteronism	hyperaldosteronism	NN	NN	_	18	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	hyperaldosteronism	hyperaldosteronism	NN	NN	_	7	nsubjpass	_	_
5	may	may	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	hyponatremia	hyponatremia	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	hyperkalemia	hyperkalemia	NN	NN	_	9	conj	_	_
12	suggesting	suggest	VBG	VBG	_	9	acl	_	_
13	PHA	pha	NN	NN	_	12	dobj	_	_
14	related	related	JJ	JJ	_	13	amod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	major	major	JJ	JJ	_	18	amod	_	_
18	importance	importance	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	colon	colon	NN	NN	_	18	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	absorption	absorption	NN	NN	_	18	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	sodium	sodium	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	this	this	DT	DT	_	6	det	_	_
5	case	case	NN	NN	_	6	compound	_	_
6	report	report	NN	NN	_	7	nsubj	_	_
7	emphasizes	emphasize	VBZ	VBZ	_	0	root	_	_
8	1	1	LS	LS	_	11	dep	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	the	the	DT	DT	_	11	det	_	_
11	possibility	possibility	NN	NN	_	7	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	syndrome	syndrome	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	acquired	acquire	VBN	VBN	_	17	amod	_	_
17	PHA	pha	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	severe	severe	JJ	JJ	_	20	amod	_	_
20	hyperkalemia	hyperkalemia	NN	NN	_	17	nmod	_	_
21	after	after	IN	IN	_	22	case	_	_
22	resection	resection	NN	NN	_	14	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	ileum	ileum	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	colon	colon	NN	NN	_	25	conj	_	_
28	responding	respond	VBG	VBG	_	25	acl	_	_
29	to	to	TO	TO	_	32	case	_	_
30	oral	oral	JJ	JJ	_	32	amod	_	_
31	salt	salt	NN	NN	_	32	compound	_	_
32	supplementation	supplementation	NN	NN	_	28	nmod	_	_
33	;	;	:	:	_	11	punct	_	_
34	2	2	LS	LS	_	38	dep	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	the	the	DT	DT	_	38	det	_	_
37	major	major	JJ	JJ	_	38	amod	_	_
38	increase	increase	NN	NN	_	11	dep	_	_
39	in	in	IN	IN	_	40	case	_	_
40	AVP	avp	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	38	cc	_	_
42	the	the	DT	DT	_	44	det	_	_
43	small	small	JJ	JJ	_	44	amod	_	_
44	increase	increase	NN	NN	_	38	conj	_	_
45	in	in	IN	IN	_	46	case	_	_
46	ANH	anh	NN	NN	_	44	nmod	_	_
47	;	;	:	:	_	11	punct	_	_
48	3	3	LS	LS	_	52	dep	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	the	the	DT	DT	_	52	det	_	_
51	strong	strong	JJ	JJ	_	52	amod	_	_
52	increase	increase	NN	NN	_	11	dep	_	_
53	in	in	IN	IN	_	55	case	_	_
54	urinary	urinary	JJ	JJ	_	55	amod	_	_
55	THF	thf	NN	NN	_	52	nmod	_	_
56	with	with	IN	IN	_	58	case	_	_
57	low	low	JJ	JJ	_	58	amod	_	_
58	THE/THF	the/thf	NN	NN	_	52	nmod	_	_
59	and	and	CC	CC	_	58	cc	_	_
60	alpha	alpha	NN	NN	_	61	compound	_	_
61	THF/THF	thf/thf	NN	NN	_	58	conj	_	_
62	ratios	ratio	NNS	NNS	_	58	dep	_	_
63	;	;	:	:	_	11	punct	_	_
64	4	4	LS	LS	_	68	dep	_	_
65	)	)	-RRB-	-RRB-	_	64	punct	_	_
66	the	the	DT	DT	_	68	det	_	_
67	normal	normal	JJ	JJ	_	68	amod	_	_
68	number	number	NN	NN	_	11	dep	_	_
69	of	of	IN	IN	_	72	case	_	_
70	lymphocytic	lymphocytic	JJ	JJ	_	72	amod	_	_
71	mineralocorticoid	mineralocorticoid	NN	NN	_	72	compound	_	_
72	receptors	receptor	NNS	NNS	_	68	nmod	_	_
73	outside	outside	IN	IN	_	76	case	_	_
74	the	the	DT	DT	_	76	det	_	_
75	acute	acute	JJ	JJ	_	76	amod	_	_
76	episode	episode	NN	NN	_	72	nmod	_	_
77	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	5	amod	_	_
3	virus	virus	NN	NN	_	5	compound	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	antigen	antigen	NN	NN	_	19	nsubj	_	_
6	2	2	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	EBNA2	ebna2	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	5	punct	_	_
11	a	a	DT	DT	_	12	det	_	_
12	protein	protein	NN	NN	_	5	appos	_	_
13	required	require	VBN	VBN	_	12	acl	_	_
14	for	for	IN	IN	_	17	case	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	lymphocyte	lymphocyte	NN	NN	_	17	compound	_	_
17	immortalization	immortalization	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	induces	induce	VBZ	VBZ	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	synthesis	synthesis	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	type	type	NN	NN	_	25	compound	_	_
24	I	i	CD	CD	_	25	nummod	_	_
25	interferon	interferon	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	31	case	_	_
27	Burkitt	burkitt	NN	NN	_	31	nmod:poss	_	_
28	's	's	POS	POS	_	31	case	_	_
29	lymphoma	lymphoma	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	lines	line	NNS	NNS	_	21	nmod	_	_
32	.	.	.	.	_	19	punct	_	_

1	Epstein-Barr	epstein-barr	JJ	JJ	_	4	amod	_	_
2	virus	virus	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	antigen	antigen	NN	NN	_	17	nsubj	_	_
5	2	2	CD	CD	_	4	nummod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	EBNA2	ebna2	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	4	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	protein	protein	NN	NN	_	4	appos	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	transformation	transformation	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	interferes	interfere	VBZ	VBZ	_	0	root	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	response	response	NN	NN	_	17	nmod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	type	type	NN	NN	_	25	compound	_	_
24	I	i	CD	CD	_	25	nummod	_	_
25	interferons	interferon	NNS	NNS	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IFN-alpha/beta	ifn-alpha/beta	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	17	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	function	function	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	conditionally	conditionally	RB	RB	_	7	advmod	_	_
7	expressed	express	VBN	VBN	_	8	amod	_	_
8	EBNA2	ebna2	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	dep	_	_
11	context	context	NN	NN	_	15	dep	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	IFN	ifn	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	4	nmod	_	_
16	in	in	IN	IN	_	21	case	_	_
17	Burkitt	burkitt	NN	NN	_	21	nmod:poss	_	_
18	's	's	POS	POS	_	21	case	_	_
19	lymphoma	lymphoma	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	EBNA2	ebna2	NN	NN	_	1	nmod	_	_
4	led	lead	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	15	case	_	_
10	both	both	DT	DT	_	11	cc:preconj	_	_
11	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	transfected	transfect	VBN	VBN	_	11	conj	_	_
14	IFN-stimulated	ifn-stimulated	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	8	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	ISGs	isg	NNS	NNS	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	genes	gene	NNS	NNS	_	15	appos	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	contain	contain	VBP	VBP	_	20	acl:relcl	_	_
23	within	within	IN	IN	_	25	case	_	_
24	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
25	promoters	promoter	NNS	NNS	_	22	nmod	_	_
26	either	either	CC	CC	_	30	cc:preconj	_	_
27	the	the	DT	DT	_	30	det	_	_
28	interferon-stimulated	interferon-stimulated	JJ	JJ	_	30	amod	_	_
29	response	response	NN	NN	_	30	compound	_	_
30	element	element	NN	NN	_	22	dobj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	ISRE	isre	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	or	or	CC	CC	_	30	cc	_	_
35	the	the	DT	DT	_	39	det	_	_
36	gamma	gamma	NN	NN	_	39	compound	_	_
37	interferon	interferon	NN	NN	_	39	compound	_	_
38	activation	activation	NN	NN	_	39	compound	_	_
39	site	site	NN	NN	_	30	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	GAS	gas	NN	NN	_	39	appos	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	search	search	NN	NN	_	15	nmod	_	_
3	of	of	IN	IN	_	6	case	_	_
4	a	a	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	2	nmod	_	_
7	for	for	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	induction	induction	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ISGs	isg	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	observed	observe	VBD	VBD	_	0	root	_	_
16	an	a	DT	DT	_	18	det	_	_
17	EBNA2-dependent	ebna2-dependent	JJ	JJ	_	18	amod	_	_
18	synthesis	synthesis	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	IFN-beta	ifn-beta	NN	NN	_	21	compound	_	_
21	mRNA	mrna	NN	NN	_	18	nmod	_	_
22	at	at	IN	IN	_	24	case	_	_
23	low	low	JJ	JJ	_	24	amod	_	_
24	levels	level	NNS	NNS	_	18	nmod	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	the	the	DT	DT	_	27	det	_	_
27	secretion	secretion	NN	NN	_	18	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	low	low	JJ	JJ	_	30	amod	_	_
30	amounts	amount	NNS	NNS	_	27	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	IFN	ifn	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	transfected	transfect	VBN	VBN	_	4	amod	_	_
3	IFN-beta	ifn-beta	NN	NN	_	4	compound	_	_
4	promoter	promoter	NN	NN	_	5	nsubj	_	_
5	responded	respond	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	EBNA2	ebna2	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	a	a	DT	DT	_	12	det	_	_
12	sequence	sequence	NN	NN	_	20	nsubjpass	_	_
13	closely	closely	RB	RB	_	14	advmod	_	_
14	resembling	resemble	VBG	VBG	_	12	acl	_	_
15	a	a	DT	DT	_	18	det	_	_
16	RBP-Jkappa	rbp-jkappa	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	site	site	NN	NN	_	14	xcomp	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	pinpointed	pinpoint	VBN	VBN	_	5	conj	_	_
21	as	as	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	potential	potential	JJ	JJ	_	24	amod	_	_
24	target	target	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	EBNA2	ebna2	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	EBNA2-dependent	ebna2-dependent	JJ	JJ	_	3	amod	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	IFN-beta	ifn-beta	NN	NN	_	7	compound	_	_
7	promoter	promoter	NN	NN	_	3	nmod	_	_
8	occurred	occur	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	EBV-negative	ebv-negative	JJ	JJ	_	14	amod	_	_
11	Burkitt	burkitt	NN	NN	_	14	nmod:poss	_	_
12	's	's	POS	POS	_	14	case	_	_
13	lymphoma	lymphoma	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	indicating	indicate	VBG	VBG	_	8	xcomp	_	_
17	that	that	IN	IN	_	23	mark	_	_
18	other	other	JJ	JJ	_	20	amod	_	_
19	EBV	ebv	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	23	nsubjpass	_	_
21	were	be	VBD	VBD	_	23	auxpass	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	required	require	VBN	VBN	_	16	ccomp	_	_
24	for	for	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	induction	induction	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	IFN-beta	ifn-beta	NN	NN	_	29	compound	_	_
29	synthesis	synthesis	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	cellular	cellular	JJ	JJ	_	8	amod	_	_
4	tumor	tumor	NN	NN	_	8	compound	_	_
5	necrosis	necrosis	NN	NN	_	8	compound	_	_
6	factor	factor	IN	IN	_	8	amod	_	_
7	receptor-associated	receptor-associated	JJ	JJ	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	1	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	1	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	lymphocyte	lymphocyte	NN	NN	_	14	compound	_	_
14	transformation	transformation	NN	NN	_	11	conj	_	_
15	by	by	IN	IN	_	18	case	_	_
16	herpesvirus	herpesvirus	NN	NN	_	18	compound	_	_
17	Saimiri	saimiri	NN	NN	_	18	compound	_	_
18	STP	stp	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	STP	stp	NN	NN	_	3	compound	_	_
3	oncoproteins	oncoprotein	NNS	NNS	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	herpesvirus	herpesvirus	NN	NN	_	7	compound	_	_
7	saimiri	saimiri	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	HVS	hvs	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	subgroup	subgroup	NN	NN	_	13	compound	_	_
12	A	a	NN	NN	_	13	compound	_	_
13	strain	strain	NN	NN	_	7	dep	_	_
14	11	11	CD	CD	_	13	nummod	_	_
15	and	and	CC	CC	_	13	cc	_	_
16	subgroup	subgroup	NN	NN	_	18	compound	_	_
17	C	c	NN	NN	_	18	compound	_	_
18	strain	strain	NN	NN	_	13	conj	_	_
19	488	488	CD	CD	_	18	nummod	_	_
20	are	be	VBP	VBP	_	22	auxpass	_	_
21	now	now	RB	RB	_	22	advmod	_	_
22	found	find	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	26	mark	_	_
24	be	be	VB	VB	_	26	auxpass	_	_
25	stably	stably	RB	RB	_	26	advmod	_	_
26	associated	associate	VBN	VBN	_	22	xcomp	_	_
27	with	with	IN	IN	_	32	case	_	_
28	tumor	tumor	NN	NN	_	31	nmod:npmod	_	_
29	necrosis	necrosis	NN	NN	_	31	nmod:npmod	_	_
30	factor	factor	NN	NN	_	31	nmod:npmod	_	_
31	receptor-associated	receptor-associated	JJ	JJ	_	32	amod	_	_
32	factor	factor	NN	NN	_	26	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	TRAF	traf	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	1	1	CD	CD	_	32	dep	_	_
37	,	,	,	,	_	36	punct	_	_
38	2	2	CD	CD	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	or	or	CC	CC	_	36	cc	_	_
41	3	3	CD	CD	_	36	conj	_	_
42	.	.	.	.	_	22	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	analyses	analysis	NNS	NNS	_	3	nsubj	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	residues	residue	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	PXQXT/S	pxqxt/s	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	case	_	_
8	STP-A11	stp-a11	NN	NN	_	3	nmod	_	_
9	as	as	IN	IN	_	10	case	_	_
10	critical	critical	JJ	JJ	_	3	advcl	_	_
11	for	for	IN	IN	_	13	case	_	_
12	TRAF	traf	NN	NN	_	13	compound	_	_
13	association	association	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	somewhat	somewhat	RB	RB	_	6	advmod	_	_
6	divergent	divergent	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	11	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	STP-C488	stp-c488	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	critical	critical	JJ	JJ	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	TRAF	traf	NN	NN	_	14	compound	_	_
14	association	association	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Mutational	mutational	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	STP-C488	stp-c488	NN	NN	_	7	nsubj	_	_
7	induced	induce	VBD	VBD	_	4	ccomp	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	correlated	correlate	VBN	VBN	_	9	acl:relcl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	ability	ability	NN	NN	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	associate	associate	VB	VB	_	15	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	TRAFs	traf	NNS	NNS	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	HVS	hvs	NN	NN	_	7	compound	_	_
3	STP-C488	stp-c488	NN	NN	_	7	compound	_	_
4	P10	p10	NN	NN	_	7	compound	_	_
5	--&gt;	--&gt;	TO	TO	_	7	dep	_	_
6	R	r	NN	NN	_	7	compound	_	_
7	mutant	mutant	NN	NN	_	9	nsubj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	deficient	deficient	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	T-lymphocyte	t-lymphocyte	NN	NN	_	13	compound	_	_
13	transformation	transformation	NN	NN	_	9	nmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	interleukin-2-independent	interleukin-2-independent	JJ	JJ	_	16	amod	_	_
16	growth	growth	NN	NN	_	13	nmod	_	_
17	but	but	CC	CC	_	9	cc	_	_
18	showed	show	VBD	VBD	_	9	conj	_	_
19	wild-type	wild-type	JJ	JJ	_	20	amod	_	_
20	phenotype	phenotype	NN	NN	_	18	dobj	_	_
21	for	for	IN	IN	_	24	case	_	_
22	marmoset	marmoset	NN	NN	_	24	compound	_	_
23	T-lymphocyte	t-lymphocyte	NN	NN	_	24	compound	_	_
24	transformation	transformation	NN	NN	_	20	nmod	_	_
25	in	in	FW	FW	_	26	compound	_	_
26	vitro	vitro	FW	FW	_	27	advmod	_	_
27	and	and	CC	CC	_	18	advmod	_	_
28	in	in	FW	FW	_	29	compound	_	_
29	vivo	vivo	FW	FW	_	27	advmod	_	_
30	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	STP-C488	stp-c488	NN	NN	_	6	compound	_	_
3	P10	p10	NN	NN	_	6	compound	_	_
4	--&gt;	--&gt;	TO	TO	_	6	dep	_	_
5	R	r	NN	NN	_	6	compound	_	_
6	mutant	mutant	NN	NN	_	9	nsubj	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	defective	defective	JJ	JJ	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	Rat-1	rat-1	NN	NN	_	13	compound	_	_
12	fibroblast	fibroblast	NN	NN	_	13	compound	_	_
13	transformation	transformation	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	9	punct	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	fibroblast	fibroblast	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	transformation	transformation	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	blocked	block	VBN	VBN	_	9	conj	_	_
21	by	by	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	TRAF2	traf2	NN	NN	_	25	compound	_	_
24	dominant-negative	dominant-negative	JJ	JJ	_	25	amod	_	_
25	mutant	mutant	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	implicate	implicate	VBP	VBP	_	0	root	_	_
4	TRAFs	traf	NNS	NNS	_	3	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	STP-C488-mediated	stp-c488-mediated	JJ	JJ	_	7	amod	_	_
7	transformation	transformation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	rodent	rodent	JJ	JJ	_	13	amod	_	_
13	fibroblasts	fibroblast	NNS	NNS	_	10	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Other	other	JJ	JJ	_	2	amod	_	_
2	factors	factor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	immortalization	immortalization	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	common	common	JJ	JJ	_	11	amod	_	_
9	marmoset	marmoset	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	may	may	MD	MD	_	16	aux	_	_
14	also	also	RB	RB	_	16	advmod	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	critical	critical	JJ	JJ	_	4	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	transformation	transformation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	rodent	rodent	JJ	JJ	_	25	amod	_	_
25	fibroblasts	fibroblast	NNS	NNS	_	22	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	Studies	study	NNS	NNS	_	0	root	_	_
2	into	into	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	10	case	_	_
6	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
7	phosphatase	phosphatase	NN	NN	_	10	compound	_	_
8	inhibitor	inhibitor	NN	NN	_	10	compound	_	_
9	phenylarsine	phenylarsine	NN	NN	_	10	compound	_	_
10	oxide	oxide	NN	NN	_	4	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	NFkappaB	nfkappab	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	4	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
17	during	during	IN	IN	_	18	case	_	_
18	aging	aging	NN	NN	_	13	nmod	_	_
19	:	:	:	:	_	1	punct	_	_
20	evidence	evidence	NN	NN	_	1	dep	_	_
21	for	for	IN	IN	_	23	case	_	_
22	altered	altered	JJ	JJ	_	23	amod	_	_
23	IkappaB-alpha	ikappab-alpha	NN	NN	_	20	nmod	_	_
24	phosphorylation	phosphorylation	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	degradation	degradation	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	1	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	4	amod	_	_
2	Factor	factor	NN	NN	_	4	compound	_	_
3	kappa	kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	11	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NFkappaB	nfkappab	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	critical	critical	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	several	several	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	involved	involve	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	20	case	_	_
17	immune	immune	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	inflammatory	inflammatory	JJ	JJ	_	17	conj	_	_
20	responses	response	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Treatment	treatment	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	variety	variety	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	stimuli	stimulus	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	12	case	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	9	punct	_	_
14	leads	lead	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	translocation	translocation	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	active	active	JJ	JJ	_	22	amod	_	_
21	p65-50	p65-50	NN	NN	_	22	compound	_	_
22	heterodimer	heterodimer	NN	NN	_	17	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	nucleus	nucleus	NN	NN	_	17	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	albeit	albeit	IN	IN	_	31	mark	_	_
28	at	at	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	lower	lower	JJR	JJR	_	31	amod	_	_
31	level	level	NN	NN	_	14	advcl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	from	from	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	elderly	elderly	JJ	JJ	_	34	nmod	_	_
38	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	pretreatment	pretreatment	NN	NN	_	8	nsubj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	PAO	pao	NN	NN	_	5	nmod	_	_
8	results	result	VBZ	VBZ	_	2	ccomp	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	inhibition	inhibition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NFkappaB	nfkappab	NN	NN	_	14	compound	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	17	nmod:npmod	_	_
17	treated	treated	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	suggesting	suggest	VBG	VBG	_	8	xcomp	_	_
22	a	a	DT	DT	_	23	det	_	_
23	role	role	NN	NN	_	21	dobj	_	_
24	for	for	IN	IN	_	26	case	_	_
25	PAO-sensitive	pao-sensitive	JJ	JJ	_	26	amod	_	_
26	phosphatase	phosphatase	NN	NN	_	23	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	activation	activation	NN	NN	_	23	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	NFkappaB	nfkappab	NN	NN	_	29	nmod	_	_
33	via	via	IN	IN	_	35	case	_	_
34	this	this	DT	DT	_	35	det	_	_
35	pathway	pathway	NN	NN	_	29	nmod	_	_
36	in	in	IN	IN	_	39	case	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	aging	aging	NN	NN	_	9	nsubj	_	_
7	does	do	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	influence	influence	VB	VB	_	4	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	sensitivity	sensitivity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	phosphatase	phosphatase	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Treatment	treatment	NN	NN	_	11	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	DMP	dmp	NN	NN	_	1	nmod	_	_
4	prior	prior	RB	RB	_	6	case	_	_
5	to	to	TO	TO	_	4	mwe	_	_
6	treatment	treatment	NN	NN	_	1	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	PAO	pao	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	TNF	tnf	NN	NN	_	8	conj	_	_
11	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	inhibition	inhibition	NN	NN	_	11	dobj	_	_
14	induced	induce	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PAO	pao	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	14	punct	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	from	from	IN	IN	_	26	case	_	_
22	both	both	CC	CC	_	23	cc:preconj	_	_
23	young	young	JJ	JJ	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	old	old	JJ	JJ	_	23	conj	_	_
26	donors	donor	NNS	NNS	_	20	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	alike	alike	RB	RB	_	26	advmod	_	_
29	.	.	.	.	_	11	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	a	a	DT	DT	_	7	det	_	_
7	failure	failure	NN	NN	_	24	nsubj	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	degrade	degrade	VB	VB	_	7	acl	_	_
10	IkappaB-alpha	ikappab-alpha	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cytosols	cytosol	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	TNF-treated	tnf-treated	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	pretreated	pretreat	VBN	VBN	_	16	acl	_	_
18	with	with	IN	IN	_	19	case	_	_
19	PAO	pao	NN	NN	_	17	nmod	_	_
20	is	be	VBZ	VBZ	_	24	cop	_	_
21	due	due	JJ	JJ	_	24	case	_	_
22	to	to	TO	TO	_	21	mwe	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	interference	interference	NN	NN	_	4	ccomp	_	_
25	with	with	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	phosphorylation	phosphorylation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	IkappaB-alpha	ikappab-alpha	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	24	cc	_	_
31	not	not	RB	RB	_	36	neg	_	_
32	due	due	JJ	JJ	_	36	case	_	_
33	to	to	TO	TO	_	32	mwe	_	_
34	its	its	PRP$	PRP$	_	36	nmod:poss	_	_
35	inhibitory	inhibitory	JJ	JJ	_	36	amod	_	_
36	effect	effect	NN	NN	_	24	conj	_	_
37	on	on	IN	IN	_	39	case	_	_
38	proteasomal	proteasomal	JJ	JJ	_	39	amod	_	_
39	degradation	degradation	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	collectively	collectively	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	PAO	pao	NN	NN	_	7	nsubj	_	_
7	interferes	interfere	VBZ	VBZ	_	4	ccomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	phosphorylation	phosphorylation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	regulated	regulate	VBN	VBN	_	14	amod	_	_
14	degradation	degradation	NN	NN	_	10	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IkappaB-alpha	ikappab-alpha	NN	NN	_	10	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	induced	induce	VBN	VBN	_	10	acl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	TNF	tnf	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	10	punct	_	_
22	without	without	IN	IN	_	23	mark	_	_
23	affecting	affect	VBG	VBG	_	7	advcl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	chymotryptic	chymotryptic	JJ	JJ	_	26	amod	_	_
26	activity	activity	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	proteasome	proteasome	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	7	punct	_	_
31	independent	independent	JJ	JJ	_	7	xcomp	_	_
32	of	of	IN	IN	_	33	case	_	_
33	age	age	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	modulation	modulation	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
6	receptor	receptor	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	inhaled	inhale	VBN	VBN	_	11	amod	_	_
10	fluticasone	fluticasone	NN	NN	_	11	compound	_	_
11	propionate	propionate	NN	NN	_	3	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	bronchial	bronchial	JJ	JJ	_	14	amod	_	_
14	mucosa	mucosa	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	blood	blood	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	subjects	subject	NNS	NNS	_	14	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	mild	mild	JJ	JJ	_	22	amod	_	_
22	asthma	asthma	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	FW	FW	_	5	amod	_	_
4	vivo	vivo	FW	FW	_	3	dep	_	_
5	regulation	regulation	NN	NN	_	15	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GR	gr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	by	by	IN	IN	_	14	case	_	_
14	glucocorticoids	glucocorticoid	NNS	NNS	_	5	nmod	_	_
15	provides	provide	VBZ	VBZ	_	1	appos	_	_
16	a	a	DT	DT	_	17	det	_	_
17	means	means	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	mark	_	_
19	modulating	modulate	VBG	VBG	_	17	acl	_	_
20	sensitivity	sensitivity	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	targeted	target	VBN	VBN	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	sought	seek	VBD	VBD	_	1	appos	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	determine	determine	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	10	det	_	_
8	in	in	FW	FW	_	10	amod	_	_
9	vivo	vivo	FW	FW	_	8	dep	_	_
10	modulation	modulation	NN	NN	_	6	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	GR	gr	NN	NN	_	14	compound	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	17	case	_	_
16	fluticasone	fluticasone	NN	NN	_	17	compound	_	_
17	propionate	propionate	NN	NN	_	10	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	FP	fp	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	subjects	subject	NNS	NNS	_	17	nmod	_	_
23	with	with	IN	IN	_	25	case	_	_
24	mild	mild	JJ	JJ	_	25	amod	_	_
25	asthma	asthma	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Ten	ten	CD	CD	_	6	nummod	_	_
4	atopic	atopic	JJ	JJ	_	5	amod	_	_
5	asthmatic	asthmatic	JJ	JJ	_	6	amod	_	_
6	subjects	subject	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	treated	treat	VBN	VBN	_	1	appos	_	_
9	with	with	IN	IN	_	12	case	_	_
10	FP	fp	NN	NN	_	12	compound	_	_
11	250	250	CD	CD	_	12	nummod	_	_
12	microg	microg	NN	NN	_	8	nmod	_	_
13	twice	twice	RB	RB	_	8	advmod	_	_
14	daily	daily	RB	RB	_	8	advmod	_	_
15	for	for	IN	IN	_	17	case	_	_
16	4	4	CD	CD	_	17	nummod	_	_
17	weeks	week	NNS	NNS	_	8	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Before	before	IN	IN	_	4	nmod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	after	after	IN	IN	_	1	conj	_	_
4	treatment	treatment	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	patients	patient	NNS	NNS	_	8	nsubj	_	_
8	underwent	undergo	VBD	VBD	_	0	root	_	_
9	fiberoptic	fiberoptic	JJ	JJ	_	10	amod	_	_
10	bronchoscopy	bronchoscopy	NN	NN	_	8	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	endobronchial	endobronchial	JJ	JJ	_	13	amod	_	_
13	biopsy	biopsy	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	sampling	sampling	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	venous	venous	JJ	JJ	_	18	amod	_	_
18	blood	blood	NN	NN	_	15	nmod	_	_
19	for	for	IN	IN	_	20	case	_	_
20	measurements	measurement	NNS	NNS	_	10	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	GR	gr	NN	NN	_	24	compound	_	_
23	mRNA	mrna	NN	NN	_	24	compound	_	_
24	levels	level	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	solution	solution	NN	NN	_	4	compound	_	_
3	hybridization	hybridization	NN	NN	_	4	compound	_	_
4	assay	assay	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	used	use	VBN	VBN	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	quantitative	quantitative	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	GR	gr	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	21	nmod	_	_
3	,	,	,	,	_	21	punct	_	_
4	a	a	DT	DT	_	8	det	_	_
5	24-hour	24-hour	JJ	JJ	_	8	amod	_	_
6	urinary	urinary	JJ	JJ	_	8	amod	_	_
7	cortisol	cortisol	NN	NN	_	8	compound	_	_
8	excretion	excretion	NN	NN	_	21	nsubjpass	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	an	a	DT	DT	_	13	det	_	_
11	adrenocorticotropic	adrenocorticotropic	JJ	JJ	_	13	amod	_	_
12	hormone	hormone	NN	NN	_	13	compound	_	_
13	test	test	NN	NN	_	8	conj	_	_
14	before	before	IN	IN	_	17	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	after	after	IN	IN	_	14	conj	_	_
17	treatment	treatment	NN	NN	_	8	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	FP	fp	NN	NN	_	17	nmod	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	performed	perform	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	A	a	DT	DT	_	6	det	_	_
4	high	high	JJ	JJ	_	6	amod	_	_
5	interindividual	interindividual	JJ	JJ	_	6	amod	_	_
6	variation	variation	NN	NN	_	12	nsubjpass	_	_
7	in	in	IN	IN	_	10	case	_	_
8	GR	gr	NN	NN	_	10	compound	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	seen	see	VBN	VBN	_	1	appos	_	_
13	.	.	.	.	_	1	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	detected	detect	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	significant	significant	JJ	JJ	_	7	amod	_	_
7	reduction	reduction	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	GR	gr	NN	NN	_	12	compound	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	7	nmod	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	endobronchial	endobronchial	JJ	JJ	_	17	amod	_	_
16	biopsy	biopsy	NN	NN	_	17	compound	_	_
17	specimens	specimen	NNS	NNS	_	7	nmod	_	_
18	after	after	IN	IN	_	20	case	_	_
19	FP	fp	NN	NN	_	20	compound	_	_
20	treatment	treatment	NN	NN	_	4	nmod	_	_
21	(	(	-LRB-	-LRB-	_	32	punct	_	_
22	36.6	36.6	CD	CD	_	32	nummod	_	_
23	+/-	+/-	CC	CC	_	22	cc	_	_
24	23.1	23.1	CD	CD	_	22	conj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	25.0	25.0	CD	CD	_	24	conj	_	_
27	+/-	+/-	CC	CC	_	26	cc	_	_
28	10.9	10.9	CD	CD	_	26	conj	_	_
29	amol	amol	NN	NN	_	32	compound	_	_
30	GR	gr	NN	NN	_	32	compound	_	_
31	mRNA/microg	mrna/microg	NN	NN	_	32	compound	_	_
32	RNA	rna	NN	NN	_	4	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	respectively	respectively	RB	RB	_	32	advmod	_	_
35	;	;	:	:	_	32	punct	_	_
36	P	p	NN	NN	_	37	dep	_	_
37	&lt;	&lt;	JJR	JJR	_	32	dep	_	_
38	.01	.01	CD	CD	_	37	nummod	_	_
39	)	)	-RRB-	-RRB-	_	32	punct	_	_
40	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
4	blood	blood	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	19	nmod	_	_
6	an	a	DT	DT	_	10	det	_	_
7	even	even	RB	RB	_	8	advmod	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	striking	striking	JJ	JJ	_	10	amod	_	_
10	downregulation	downregulation	NN	NN	_	19	nsubjpass	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	GR	gr	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	17	case	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	cognate	cognate	JJ	JJ	_	17	amod	_	_
17	ligand	ligand	NN	NN	_	10	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	documented	document	VBN	VBN	_	0	root	_	_
20	(	(	-LRB-	-LRB-	_	31	punct	_	_
21	30.3	30.3	CD	CD	_	31	nummod	_	_
22	+/-	+/-	CC	CC	_	21	cc	_	_
23	26.5	26.5	CD	CD	_	21	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	8.8	8.8	CD	CD	_	23	conj	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	5	5	CD	CD	_	25	conj	_	_
28	amol	amol	NN	NN	_	31	compound	_	_
29	GR	gr	NN	NN	_	31	compound	_	_
30	mRNA/microg	mrna/microg	NN	NN	_	31	compound	_	_
31	RNA	rna	NN	NN	_	19	dep	_	_
32	,	,	,	,	_	31	punct	_	_
33	respectively	respectively	RB	RB	_	31	advmod	_	_
34	;	;	:	:	_	31	punct	_	_
35	P	p	NN	NN	_	36	dep	_	_
36	&lt;	&lt;	JJR	JJR	_	31	dep	_	_
37	.001	.001	CD	CD	_	36	nummod	_	_
38	)	)	-RRB-	-RRB-	_	31	punct	_	_
39	,	,	,	,	_	19	punct	_	_
40	possibly	possibly	RB	RB	_	41	advmod	_	_
41	reflecting	reflect	VBG	VBG	_	19	xcomp	_	_
42	differences	difference	NNS	NNS	_	41	dobj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	glucocorticoid	glucocorticoid	NN	NN	_	45	compound	_	_
45	sensitivity	sensitivity	NN	NN	_	42	nmod	_	_
46	between	between	IN	IN	_	47	case	_	_
47	tissues	tissue	NNS	NNS	_	42	nmod	_	_
48	.	.	.	.	_	19	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	small	small	JJ	JJ	_	5	amod	_	_
3	but	but	CC	CC	_	2	cc	_	_
4	significant	significant	JJ	JJ	_	2	conj	_	_
5	reduction	reduction	NN	NN	_	13	nsubjpass	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	24-hour	24-hour	JJ	JJ	_	11	amod	_	_
9	urinary	urinary	JJ	JJ	_	11	amod	_	_
10	cortisol	cortisol	NN	NN	_	11	compound	_	_
11	excretion	excretion	NN	NN	_	5	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	(	(	-LRB-	-LRB-	_	27	punct	_	_
15	233	233	CD	CD	_	22	nummod	_	_
16	+/-	+/-	CC	CC	_	15	cc	_	_
17	109	109	CD	CD	_	15	conj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	157	157	CD	CD	_	17	conj	_	_
20	+/-	+/-	CC	CC	_	19	cc	_	_
21	66	66	CD	CD	_	19	conj	_	_
22	nmol/L	nmol/l	NN	NN	_	27	dep	_	_
23	,	,	,	,	_	22	punct	_	_
24	respectively	respectively	RB	RB	_	22	advmod	_	_
25	;	;	:	:	_	27	punct	_	_
26	P	p	NN	NN	_	27	dep	_	_
27	&lt;	&lt;	JJR	JJR	_	13	parataxis	_	_
28	.01	.01	CD	CD	_	27	nummod	_	_
29	)	)	-RRB-	-RRB-	_	27	punct	_	_
30	,	,	,	,	_	13	punct	_	_
31	whereas	whereas	IN	IN	_	13	dep	_	_
32	the	the	DT	DT	_	34	det	_	_
33	feedback	feedback	NN	NN	_	34	compound	_	_
34	regulation	regulation	NN	NN	_	51	nsubj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	glucocorticoid	glucocorticoid	NN	NN	_	37	compound	_	_
37	synthesis	synthesis	NN	NN	_	34	nmod	_	_
38	by	by	IN	IN	_	43	case	_	_
39	means	means	NNS	NNS	_	43	dep	_	_
40	of	of	IN	IN	_	43	case	_	_
41	the	the	DT	DT	_	43	det	_	_
42	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	43	amod	_	_
43	axis	axis	NN	NN	_	34	nmod	_	_
44	as	as	IN	IN	_	45	mark	_	_
45	assessed	assess	VBN	VBN	_	34	dep	_	_
46	by	by	IN	IN	_	50	case	_	_
47	the	the	DT	DT	_	50	det	_	_
48	adrenocorticotropic	adrenocorticotropic	JJ	JJ	_	50	amod	_	_
49	hormone	hormone	NN	NN	_	50	compound	_	_
50	test	test	NN	NN	_	45	nmod	_	_
51	remained	remain	VBD	VBD	_	13	parataxis	_	_
52	normal	normal	JJ	JJ	_	51	xcomp	_	_
53	after	after	IN	IN	_	54	case	_	_
54	treatment	treatment	NN	NN	_	51	nmod	_	_
55	with	with	IN	IN	_	56	case	_	_
56	FP	fp	NN	NN	_	54	nmod	_	_
57	.	.	.	.	_	13	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	study	study	NN	NN	_	4	nmod	_	_
8	confirm	confirm	VBP	VBP	_	1	appos	_	_
9	the	the	DT	DT	_	10	det	_	_
10	potency	potency	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	inhaled	inhale	VBN	VBN	_	15	amod	_	_
14	corticosteroid	corticosteroid	NN	NN	_	15	compound	_	_
15	FP	fp	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	provide	provide	VBP	VBP	_	8	conj	_	_
18	evidence	evidence	NN	NN	_	17	dobj	_	_
19	for	for	IN	IN	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	considerable	considerable	JJ	JJ	_	24	amod	_	_
22	tissue-specific	tissue-specific	JJ	JJ	_	24	amod	_	_
23	interindividual	interindividual	JJ	JJ	_	24	amod	_	_
24	variation	variation	NN	NN	_	18	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	expression	expression	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	GR	gr	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	1	punct	_	_

1	A	a	DT	DT	_	5	det	_	_
2	novel	novel	JJ	JJ	_	5	amod	_	_
3	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	5	amod	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	regulating	regulate	VBG	VBG	_	5	acl	_	_
7	tumor	tumor	NN	NN	_	12	compound	_	_
8	necrosis	necrosis	NN	NN	_	12	compound	_	_
9	factor	factor	NN	NN	_	12	compound	_	_
10	alpha	alpha	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	6	dobj	_	_
13	:	:	:	:	_	5	punct	_	_
14	molecular	molecular	JJ	JJ	_	15	amod	_	_
15	cloning	cloning	NN	NN	_	5	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	sequencing	sequencing	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	characterization	characterization	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	chromosomal	chromosomal	JJ	JJ	_	23	amod	_	_
23	assignment	assignment	NN	NN	_	15	conj	_	_
24	.	.	.	.	_	5	punct	_	_

1	Lipopolysaccharide	lipopolysaccharide	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	LPS	lps	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	potent	potent	JJ	JJ	_	8	amod	_	_
8	stimulator	stimulator	NN	NN	_	0	root	_	_
9	of	of	IN	IN	_	10	case	_	_
10	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	macrophages	macrophage	NNS	NNS	_	10	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	causing	cause	VBG	VBG	_	8	acl	_	_
15	secretion	secretion	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	tumor	tumor	NN	NN	_	20	compound	_	_
18	necrosis	necrosis	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	15	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	TNF-alpha	tnf-alpha	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	other	other	JJ	JJ	_	27	amod	_	_
26	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
27	mediators	mediator	NNS	NNS	_	20	conj	_	_
28	.	.	.	.	_	8	punct	_	_

1	Given	given	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	deleterious	deleterious	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	14	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	host	host	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	it	it	PRP	PRP	_	14	nsubjpass	_	_
12	has	have	VBZ	VBZ	_	14	aux	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	postulated	postulate	VBN	VBN	_	0	root	_	_
15	that	that	IN	IN	_	22	mark	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	22	nsubjpass	_	_
19	must	must	MD	MD	_	22	aux	_	_
20	be	be	VB	VB	_	22	auxpass	_	_
21	tightly	tightly	RB	RB	_	22	advmod	_	_
22	regulated	regulate	VBN	VBN	_	14	ccomp	_	_
23	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	nature	nature	NN	NN	_	17	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	s	s	NNS	NNS	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	control	control	VBP	VBP	_	6	acl:relcl	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	humans	human	NNS	NNS	_	14	nmod	_	_
17	remains	remain	VBZ	VBZ	_	0	root	_	_
18	obscure	obscure	JJ	JJ	_	17	xcomp	_	_
19	,	,	,	,	_	17	punct	_	_
20	although	although	IN	IN	_	24	mark	_	_
21	NF-kappaB	nf-kappab	NN	NN	_	24	nsubjpass	_	_
22	has	have	VBZ	VBZ	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	suggested	suggest	VBN	VBN	_	17	dep	_	_
25	.	.	.	.	_	17	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	10	nsubj	_	_
4	pertaining	pertain	VBG	VBG	_	3	acl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	macrophage	macrophage	NN	NN	_	7	compound	_	_
7	response	response	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	LPS	lps	NN	NN	_	7	nmod	_	_
10	identified	identify	VBD	VBD	_	0	root	_	_
11	a	a	DT	DT	_	14	det	_	_
12	novel	novel	JJ	JJ	_	14	amod	_	_
13	DNA-binding	dna-binding	JJ	JJ	_	14	amod	_	_
14	domain	domain	NN	NN	_	10	dobj	_	_
15	located	located	JJ	JJ	_	14	amod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	-550	-550	CD	CD	_	15	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	-487	-487	CD	CD	_	17	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	TNF-alpha	tnf-alpha	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	15	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	contains	contain	VBZ	VBZ	_	14	acl:relcl	_	_
27	transcriptional	transcriptional	JJ	JJ	_	28	amod	_	_
28	activity	activity	NN	NN	_	26	dobj	_	_
29	,	,	,	,	_	26	punct	_	_
30	but	but	CC	CC	_	26	cc	_	_
31	lacks	lack	VBZ	VBZ	_	26	conj	_	_
32	any	any	DT	DT	_	35	det	_	_
33	known	known	JJ	JJ	_	35	amod	_	_
34	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	35	amod	_	_
35	sites	site	NNS	NNS	_	31	dobj	_	_
36	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	this	this	DT	DT	_	6	det	_	_
5	DNA	dna	NN	NN	_	6	compound	_	_
6	fragment	fragment	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	isolate	isolate	VB	VB	_	3	advcl	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	purify	purify	VB	VB	_	8	conj	_	_
11	a	a	DT	DT	_	13	det	_	_
12	60-kDa	60-kda	JJ	JJ	_	13	amod	_	_
13	protein	protein	NN	NN	_	8	dobj	_	_
14	binding	bind	VBG	VBG	_	13	acl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	this	this	DT	DT	_	17	det	_	_
17	fragment	fragment	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	3	cc	_	_
19	obtained	obtain	VBN	VBN	_	3	conj	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	amino-terminal	amino-terminal	JJ	JJ	_	22	amod	_	_
22	sequence	sequence	NN	NN	_	19	dobj	_	_
23	,	,	,	,	_	19	punct	_	_
24	which	which	WDT	WDT	_	26	nsubjpass	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	used	use	VBN	VBN	_	19	dep	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	design	design	VB	VB	_	26	xcomp	_	_
29	degenerate	degenerate	JJ	JJ	_	30	amod	_	_
30	probes	probe	NNS	NNS	_	28	dobj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	screen	screen	VB	VB	_	30	acl	_	_
33	a	a	DT	DT	_	35	det	_	_
34	cDNA	cdna	NN	NN	_	35	compound	_	_
35	library	library	NN	NN	_	32	dobj	_	_
36	from	from	IN	IN	_	38	case	_	_
37	THP-1	thp-1	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	32	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	novel	novel	JJ	JJ	_	4	amod	_	_
3	cDNA	cdna	NN	NN	_	4	compound	_	_
4	clone	clone	NN	NN	_	10	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	1.8	1.8	CD	CD	_	7	nummod	_	_
7	kb	kb	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	isolated	isolate	VBN	VBN	_	0	root	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	fully	fully	RB	RB	_	13	advmod	_	_
13	sequenced	sequence	VBN	VBN	_	10	conj	_	_
14	.	.	.	.	_	10	punct	_	_

1	Characterization	characterization	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	this	this	DT	DT	_	5	det	_	_
4	cDNA	cdna	NN	NN	_	5	compound	_	_
5	clone	clone	NN	NN	_	1	nmod	_	_
6	revealed	reveal	VBD	VBD	_	22	dep	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
9	induction	induction	NN	NN	_	11	nsubj	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	dependent	dependent	JJ	JJ	_	6	ccomp	_	_
12	on	on	IN	IN	_	14	case	_	_
13	LPS	lps	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	THP-1	thp-1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	;	;	:	:	_	6	punct	_	_
19	hence	hence	RB	RB	_	22	advmod	_	_
20	,	,	,	,	_	22	punct	_	_
21	the	the	DT	DT	_	22	det	_	_
22	name	name	NN	NN	_	0	root	_	_
23	LPS-induced	lps-induced	JJ	JJ	_	25	amod	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	22	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	LITAF	litaf	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	22	punct	_	_

1	Inhibition	inhibition	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	LITAF	litaf	NN	NN	_	5	compound	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	THP-1	thp-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	resulted	result	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	reduction	reduction	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	15	compound	_	_
15	transcripts	transcript	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	level	level	NN	NN	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	expression	expression	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	LITAF	litaf	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	5	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	observed	observe	VBN	VBN	_	0	root	_	_
13	predominantly	predominantly	RB	RB	_	12	advmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	placenta	placenta	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	peripheral	peripheral	JJ	JJ	_	20	amod	_	_
19	blood	blood	NN	NN	_	20	compound	_	_
20	leukocytes	leukocyte	NNS	NNS	_	16	conj	_	_
21	,	,	,	,	_	16	punct	_	_
22	lymph	lymph	NN	NN	_	23	compound	_	_
23	nodes	node	NNS	NNS	_	16	conj	_	_
24	,	,	,	,	_	16	punct	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	the	the	DT	DT	_	27	det	_	_
27	spleen	spleen	NN	NN	_	16	conj	_	_
28	.	.	.	.	_	12	punct	_	_

1	Finally	finally	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	chromosomal	chromosomal	JJ	JJ	_	4	amod	_	_
4	localization	localization	NN	NN	_	10	nsubj	_	_
5	using	use	VBG	VBG	_	4	acl	_	_
6	fluorescence	fluorescence	NN	NN	_	9	compound	_	_
7	in	in	FW	FW	_	9	compound	_	_
8	situ	situ	FW	FW	_	9	compound	_	_
9	hybridization	hybridization	NN	NN	_	5	dobj	_	_
10	revealed	reveal	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	13	mark	_	_
12	LITAF	litaf	NN	NN	_	13	nsubj	_	_
13	mapped	map	VBD	VBD	_	10	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	chromosome	chromosome	NN	NN	_	16	compound	_	_
16	16p12-16p13.3	16p12-16p13.3	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	LITAF	litaf	NN	NN	_	8	nsubj	_	_
8	plays	play	VBZ	VBZ	_	5	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	human	human	JJ	JJ	_	19	amod	_	_
18	TNF-alpha	tnf-alpha	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	proposes	propose	VBZ	VBZ	_	8	conj	_	_
22	a	a	DT	DT	_	24	det	_	_
23	new	new	JJ	JJ	_	24	amod	_	_
24	mechanism	mechanism	NN	NN	_	21	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	control	control	VB	VB	_	24	acl	_	_
27	TNF-alpha	tnf-alpha	NN	NN	_	29	compound	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	expression	expression	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	5	punct	_	_

1	p38	p38	NN	NN	_	4	compound	_	_
2	mitogen-activated	mitogen-activated	JJ	JJ	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	kinase	kinase	NN	NN	_	5	nsubj	_	_
5	mediates	mediate	VBZ	VBZ	_	0	root	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	integration	integration	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	TCR/CD28	tcr/cd28	NN	NN	_	10	compound	_	_
10	costimulation	costimulation	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	primary	primary	JJ	JJ	_	15	amod	_	_
13	murine	murine	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Optimal	optimal	JJ	JJ	_	4	amod	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	5	nsubj	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	two	two	CD	CD	_	7	nummod	_	_
7	signals	signal	NNS	NNS	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	one	one	CD	CD	_	7	appos	_	_
10	generated	generate	VBN	VBN	_	9	acl	_	_
11	by	by	IN	IN	_	12	case	_	_
12	TCR	tcr	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	another	another	DT	DT	_	9	conj	_	_
15	by	by	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	CD28	cd28	NN	NN	_	19	compound	_	_
18	costimulatory	costimulatory	JJ	JJ	_	19	amod	_	_
19	receptor	receptor	NN	NN	_	14	dep	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	regulation	regulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	17	case	_	_
10	costimulation-induced	costimulation-induced	JJ	JJ	_	17	amod	_	_
11	mitogen-activated	mitogen-activated	JJ	JJ	_	17	amod	_	_
12	protein	protein	NN	NN	_	17	compound	_	_
13	kinase	kinase	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	MAPK	mapk	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	activation	activation	NN	NN	_	8	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	primary	primary	JJ	JJ	_	22	amod	_	_
20	mouse	mouse	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	8	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	that	that	DT	DT	_	2	nmod	_	_
5	reported	report	VBN	VBN	_	4	acl	_	_
6	for	for	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	Jurkat	jurkat	NN	NN	_	10	compound	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	found	find	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	29	mark	_	_
15	p38	p38	NN	NN	_	16	compound	_	_
16	MAPK	mapk	NN	NN	_	29	nsubjpass	_	_
17	,	,	,	,	_	16	punct	_	_
18	but	but	CC	CC	_	16	cc	_	_
19	not	not	RB	RB	_	22	neg	_	_
20	Jun	jun	NN	NN	_	22	compound	_	_
21	NH2-terminal	nh2-terminal	JJ	JJ	_	22	amod	_	_
22	kinase	kinase	NN	NN	_	16	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	JNK	jnk	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	,	,	,	,	_	29	punct	_	_
27	is	be	VBZ	VBZ	_	29	auxpass	_	_
28	weakly	weakly	RB	RB	_	29	advmod	_	_
29	activated	activate	VBN	VBN	_	13	ccomp	_	_
30	upon	upon	IN	IN	_	31	case	_	_
31	stimulation	stimulation	NN	NN	_	29	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	either	either	CC	CC	_	34	cc:preconj	_	_
34	anti-CD3	anti-cd3	NN	NN	_	31	nmod	_	_
35	or	or	CC	CC	_	34	cc	_	_
36	anti-CD28	anti-cd28	NN	NN	_	34	conj	_	_
37	in	in	IN	IN	_	39	case	_	_
38	murine	murine	JJ	JJ	_	39	amod	_	_
39	thymocytes	thymocyte	NNS	NNS	_	29	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	splenic	splenic	JJ	JJ	_	43	amod	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	39	conj	_	_
44	.	.	.	.	_	13	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	p38	p38	NN	NN	_	4	compound	_	_
4	MAPK	mapk	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	activated	activate	VBN	VBN	_	0	root	_	_
7	strongly	strongly	RB	RB	_	8	advmod	_	_
8	and	and	CC	CC	_	6	advmod	_	_
9	synergistically	synergistically	RB	RB	_	8	advmod	_	_
10	by	by	IN	IN	_	13	case	_	_
11	either	either	CC	CC	_	13	cc:preconj	_	_
12	CD3/CD28	cd3/cd28	NN	NN	_	13	compound	_	_
13	coligation	coligation	NN	NN	_	6	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	PMA/Ca2+	pma/ca2+	NN	NN	_	17	compound	_	_
16	ionophore	ionophore	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	mimics	mimic	VBZ	VBZ	_	13	acl:relcl	_	_
21	TCR-CD3/CD28-mediated	tcr-cd3/cd28-mediated	JJ	JJ	_	22	amod	_	_
22	signaling	signaling	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	6	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	p38	p38	NN	NN	_	4	compound	_	_
4	MAPK	mapk	NN	NN	_	1	nmod	_	_
5	correlates	correlate	VBZ	VBZ	_	0	root	_	_
6	closely	closely	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	stimulation	stimulation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	proliferation	proliferation	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	PMA-induced	pma-induced	NN	NN	_	6	compound	_	_
5	JNK	jnk	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	Ca2+	ca2+	NN	NN	_	11	compound	_	_
11	ionophore	ionophore	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	proliferation	proliferation	NN	NN	_	32	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	production	production	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-2	il-2	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-4	il-4	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	IFN-gamma	ifn-gamma	NN	NN	_	7	conj	_	_
13	induced	induce	VBN	VBN	_	7	acl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	both	both	CC	CC	_	16	cc:preconj	_	_
16	CD3	cd3	NN	NN	_	13	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CD3/CD28	cd3/cd28	NN	NN	_	19	compound	_	_
19	ligation	ligation	NN	NN	_	16	conj	_	_
20	and	and	CC	CC	_	3	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	expression	expression	NN	NN	_	3	conj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	dep	_	_
26	c-Jun	c-jun	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	ATF-2	atf-2	NN	NN	_	26	conj	_	_
29	proteins	protein	NNS	NNS	_	26	dep	_	_
30	are	be	VBP	VBP	_	32	auxpass	_	_
31	each	each	DT	DT	_	32	advmod	_	_
32	blocked	block	VBN	VBN	_	0	root	_	_
33	by	by	IN	IN	_	38	case	_	_
34	the	the	DT	DT	_	38	det	_	_
35	p38	p38	NN	NN	_	38	compound	_	_
36	MAPK	mapk	NN	NN	_	38	compound	_	_
37	inhibitor	inhibitor	NN	NN	_	38	compound	_	_
38	SB203580	sb203580	NN	NN	_	32	nmod	_	_
39	.	.	.	.	_	32	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	p38	p38	NN	NN	_	6	compound	_	_
6	MAPK	mapk	NN	NN	_	9	nsubj	_	_
7	1	1	LS	LS	_	9	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	plays	play	VBZ	VBZ	_	3	ccomp	_	_
10	an	a	DT	DT	_	12	det	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	integration	integration	NN	NN	_	9	nmod	_	_
16	during	during	IN	IN	_	17	case	_	_
17	costimulation	costimulation	NN	NN	_	9	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	primary	primary	JJ	JJ	_	22	amod	_	_
20	mouse	mouse	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	17	nmod	_	_
23	,	,	,	,	_	9	punct	_	_
24	2	2	LS	LS	_	28	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	may	may	MD	MD	_	28	aux	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	involved	involve	VBN	VBN	_	9	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	dep	_	_
31	induction	induction	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	34	case	_	_
33	c-Jun	c-jun	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	31	nmod	_	_
35	and	and	CC	CC	_	31	cc	_	_
36	augmentation	augmentation	NN	NN	_	31	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	AP-1	ap-1	NN	NN	_	40	compound	_	_
39	transcriptional	transcriptional	JJ	JJ	_	40	amod	_	_
40	activity	activity	NN	NN	_	36	nmod	_	_
41	,	,	,	,	_	9	punct	_	_
42	and	and	CC	CC	_	9	cc	_	_
43	3	3	LS	LS	_	45	dep	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	regulates	regulate	VBZ	VBZ	_	9	conj	_	_
46	whether	whether	IN	IN	_	49	mark	_	_
47	T	t	NN	NN	_	48	compound	_	_
48	cells	cell	NNS	NNS	_	49	nsubj	_	_
49	enter	enter	VBP	VBP	_	45	ccomp	_	_
50	a	a	DT	DT	_	51	det	_	_
51	state	state	NN	NN	_	49	dobj	_	_
52	of	of	IN	IN	_	54	case	_	_
53	functional	functional	JJ	JJ	_	54	amod	_	_
54	unresponsiveness	unresponsiveness	NN	NN	_	51	nmod	_	_
55	.	.	.	.	_	3	punct	_	_

1	Engagement	engagement	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	natural	natural	JJ	JJ	_	5	amod	_	_
4	cytotoxicity	cytotoxicity	NN	NN	_	5	compound	_	_
5	programs	program	NNS	NNS	_	1	nmod	_	_
6	regulates	regulate	VBZ	VBZ	_	0	root	_	_
7	AP-1	ap-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	NKL	nkl	NN	NN	_	15	compound	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	NK	nk	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	NK	nk	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	cytotoxicity	cytotoxicity	NN	NN	_	9	nsubj	_	_
4	is	be	VBZ	VBZ	_	9	cop	_	_
5	a	a	DT	DT	_	9	det	_	_
6	fast	fast	JJ	JJ	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	efficient	efficient	JJ	JJ	_	6	conj	_	_
9	mechanism	mechanism	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	target	target	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	lysis	lysis	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	Using	use	VBG	VBG	_	12	advcl	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	such	such	JJ	JJ	_	9	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	multiplex	multiplex	JJ	JJ	_	9	amod	_	_
8	messenger	messenger	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	show	show	VBP	VBP	_	0	root	_	_
13	here	here	RB	RB	_	12	advmod	_	_
14	that	that	IN	IN	_	24	mark	_	_
15	natural	natural	JJ	JJ	_	16	amod	_	_
16	cytotoxicity	cytotoxicity	NN	NN	_	24	nsubj	_	_
17	exerted	exert	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	human	human	JJ	JJ	_	23	amod	_	_
21	NKL	nkl	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	line	line	NN	NN	_	17	nmod	_	_
24	correlates	correlate	VBZ	VBZ	_	12	ccomp	_	_
25	with	with	IN	IN	_	27	case	_	_
26	mRNA	mrna	NN	NN	_	27	compound	_	_
27	accumulation	accumulation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	39	case	_	_
29	very	very	RB	RB	_	39	advmod	_	_
30	early	early	JJ	JJ	_	39	amod	_	_
31	activator	activator	NN	NN	_	39	compound	_	_
32	protein	protein	NN	NN	_	39	compound	_	_
33	(	(	-LRB-	-LRB-	_	39	punct	_	_
34	AP	ap	NN	NN	_	39	compound	_	_
35	)	)	-RRB-	-RRB-	_	39	punct	_	_
36	-1	-1	CD	CD	_	39	nummod	_	_
37	transcription	transcription	NN	NN	_	39	compound	_	_
38	factor	factor	NN	NN	_	39	compound	_	_
39	genes	gene	NNS	NNS	_	27	nmod	_	_
40	such	such	JJ	JJ	_	42	case	_	_
41	as	as	IN	IN	_	40	mwe	_	_
42	JunB	junb	NN	NN	_	39	nmod	_	_
43	,	,	,	,	_	42	punct	_	_
44	FosB	fosb	NN	NN	_	42	conj	_	_
45	and	and	CC	CC	_	42	cc	_	_
46	c-Fos	c-fos	NN	NN	_	42	conj	_	_
47	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	DNA-binding	dna-binding	JJ	JJ	_	5	amod	_	_
5	activities	activity	NNS	NNS	_	10	nsubjpass	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Jun-Fos	jun-fos	NN	NN	_	8	compound	_	_
8	heterodimers	heterodimer	NNS	NNS	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	observed	observe	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	15	case	_	_
12	electrophoretic	electrophoretic	JJ	JJ	_	15	amod	_	_
13	mobility	mobility	NN	NN	_	15	compound	_	_
14	shift	shift	NN	NN	_	15	compound	_	_
15	assays	assay	NNS	NNS	_	10	nmod	_	_
16	during	during	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	course	course	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	natural	natural	JJ	JJ	_	21	amod	_	_
21	cytotoxicity	cytotoxicity	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Interaction	interaction	NN	NN	_	16	nsubj	_	_
2	between	between	IN	IN	_	6	case	_	_
3	immunoglobulin-like	immunoglobulin-like	JJ	JJ	_	6	amod	_	_
4	transcript-2/leukocyte	transcript-2/leukocyte	NN	NN	_	6	compound	_	_
5	Ig-like	ig-like	JJ	JJ	_	6	amod	_	_
6	receptor	receptor	NN	NN	_	1	nmod	_	_
7	1	1	CD	CD	_	6	nummod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	NKL	nkl	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	HLA-B27	hla-b27	NN	NN	_	6	conj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	target	target	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	leads	lead	VBZ	VBZ	_	0	root	_	_
17	to	to	TO	TO	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	impairment	impairment	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	NKL	nkl	NN	NN	_	23	compound	_	_
22	natural	natural	JJ	JJ	_	23	amod	_	_
23	cytotoxicity	cytotoxicity	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	19	punct	_	_
25	which	which	WDT	WDT	_	26	nsubj	_	_
26	correlates	correlate	VBZ	VBZ	_	19	acl:relcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	an	a	DT	DT	_	29	det	_	_
29	absence	absence	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	JunB	junb	NN	NN	_	33	compound	_	_
32	,	,	,	,	_	33	punct	_	_
33	FosB	fosb	NN	NN	_	29	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	and	and	CC	CC	_	33	cc	_	_
36	c-Fos	c-fos	NN	NN	_	37	compound	_	_
37	transcription	transcription	NN	NN	_	33	conj	_	_
38	,	,	,	,	_	29	punct	_	_
39	as	as	RB	RB	_	29	cc	_	_
40	well	well	RB	RB	_	39	mwe	_	_
41	as	as	IN	IN	_	39	mwe	_	_
42	an	a	DT	DT	_	43	det	_	_
43	absence	absence	NN	NN	_	29	conj	_	_
44	of	of	IN	IN	_	47	case	_	_
45	their	they	PRP$	PRP$	_	47	nmod:poss	_	_
46	DNA-binding	dna-binding	JJ	JJ	_	47	amod	_	_
47	activity	activity	NN	NN	_	43	nmod	_	_
48	.	.	.	.	_	16	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	thus	thus	RB	RB	_	4	advmod	_	_
4	indicate	indicate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	19	mark	_	_
6	,	,	,	,	_	19	punct	_	_
7	despite	despite	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	rapidity	rapidity	NN	NN	_	19	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	NK	nk	NN	NN	_	12	nmod:npmod	_	_
12	cell-mediated	cell-mediated	JJ	JJ	_	13	amod	_	_
13	lysis	lysis	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	AP-1	ap-1	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	activated	activate	VBN	VBN	_	4	ccomp	_	_
20	during	during	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	early	early	JJ	JJ	_	23	amod	_	_
23	stage	stage	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	NK	nk	NN	NN	_	28	compound	_	_
26	cell	cell	NN	NN	_	28	compound	_	_
27	cytolytic	cytolytic	JJ	JJ	_	28	amod	_	_
28	programs	program	NNS	NNS	_	23	nmod	_	_
29	and	and	CC	CC	_	19	cc	_	_
30	that	that	IN	IN	_	42	mark	_	_
31	engagement	engagement	NN	NN	_	42	nsubj	_	_
32	of	of	IN	IN	_	36	case	_	_
33	NK	nk	NN	NN	_	36	compound	_	_
34	cell	cell	NN	NN	_	36	compound	_	_
35	inhibitory	inhibitory	JJ	JJ	_	36	amod	_	_
36	receptors	receptor	NNS	NNS	_	31	nmod	_	_
37	for	for	IN	IN	_	41	case	_	_
38	MHC	mhc	NN	NN	_	41	compound	_	_
39	class	class	NN	NN	_	41	compound	_	_
40	I	i	CD	CD	_	41	nummod	_	_
41	molecules	molecule	NNS	NNS	_	36	nmod	_	_
42	impairs	impair	VBZ	VBZ	_	19	conj	_	_
43	the	the	DT	DT	_	46	det	_	_
44	very	very	RB	RB	_	45	advmod	_	_
45	early	early	JJ	JJ	_	46	amod	_	_
46	activation	activation	NN	NN	_	42	dobj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	AP-1	ap-1	NN	NN	_	46	nmod	_	_
49	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	synergy	synergy	NN	NN	_	8	nsubj	_	_
4	between	between	IN	IN	_	5	case	_	_
5	IL-12	il-12	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-2	il-2	NN	NN	_	5	conj	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	p38	p38	NN	NN	_	12	compound	_	_
10	mitogen-activated	mitogen-activated	JJ	JJ	_	12	amod	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	kinase	kinase	NN	NN	_	8	dobj	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	associated	associate	VBN	VBN	_	8	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	augmentation	augmentation	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	STAT	stat	NN	NN	_	22	compound	_	_
21	serine	serine	NN	NN	_	22	compound	_	_
22	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	IL-12	il-12	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-2	il-2	NN	NN	_	1	conj	_	_
4	can	can	MD	MD	_	5	aux	_	_
5	stimulate	stimulate	VB	VB	_	0	root	_	_
6	mitogen-	mitogen-	NN	NN	_	10	amod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	CD3-activated	cd3-activated	JJ	JJ	_	6	conj	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	5	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	proliferate	proliferate	VB	VB	_	5	xcomp	_	_
13	,	,	,	,	_	5	punct	_	_
14	produce	produce	VB	VB	_	5	conj	_	_
15	IFN-gamma	ifn-gamma	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	kill	kill	VB	VB	_	5	conj	_	_
19	tumor	tumor	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	18	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	magnitude	magnitude	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	these	these	DT	DT	_	6	det	_	_
5	functional	functional	JJ	JJ	_	6	amod	_	_
6	responses	response	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	aux	_	_
8	greatly	greatly	RB	RB	_	9	advmod	_	_
9	augmented	augmented	JJ	JJ	_	0	root	_	_
10	when	when	WRB	WRB	_	14	advmod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	activated	activate	VBN	VBN	_	9	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	combination	combination	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-12	il-12	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-2	il-2	NN	NN	_	19	conj	_	_
22	.	.	.	.	_	9	punct	_	_

1	Although	although	IN	IN	_	8	mark	_	_
2	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
3	blood	blood	NN	NN	_	5	compound	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	8	nsubj	_	_
6	are	be	VBP	VBP	_	8	cop	_	_
7	largely	largely	RB	RB	_	8	advmod	_	_
8	unresponsive	unresponsive	JJ	JJ	_	28	advcl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
12	without	without	IN	IN	_	14	case	_	_
13	prior	prior	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	28	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	small	small	JJ	JJ	_	18	amod	_	_
18	subset	subset	NN	NN	_	28	nsubjpass	_	_
19	of	of	IN	IN	_	22	case	_	_
20	CD8+	cd8+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	CD8+CD18bright	cd8+cd18bright	NN	NN	_	18	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	is	be	VBZ	VBZ	_	28	auxpass	_	_
27	strongly	strongly	RB	RB	_	28	advmod	_	_
28	activated	activate	VBN	VBN	_	0	root	_	_
29	by	by	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	combination	combination	NN	NN	_	28	nmod	_	_
32	of	of	IN	IN	_	33	case	_	_
33	IL-12	il-12	NN	NN	_	31	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	IL-2	il-2	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	28	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	synergy	synergy	NN	NN	_	18	nsubj	_	_
10	between	between	IN	IN	_	11	case	_	_
11	IL-12	il-12	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-2	il-2	NN	NN	_	11	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	CD8+CD18bright	cd8+cd18bright	NN	NN	_	17	compound	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	9	nmod	_	_
18	correlates	correlate	VBZ	VBZ	_	5	ccomp	_	_
19	with	with	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	stress	stress	NN	NN	_	25	compound	_	_
25	kinases	kinase	NNS	NNS	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	p38	p38	NN	NN	_	33	compound	_	_
28	mitogen-activated	mitogen-activated	JJ	JJ	_	33	amod	_	_
29	protein	protein	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	MAP	map	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	kinase	kinase	NN	NN	_	25	conj	_	_
34	and	and	CC	CC	_	25	cc	_	_
35	stress-activated	stress-activated	JJ	JJ	_	43	amod	_	_
36	protein	protein	NN	NN	_	43	compound	_	_
37	kinase	kinase	NN	NN	_	43	compound	_	_
38	(	(	-LRB-	-LRB-	_	43	punct	_	_
39	SAPK	sapk	NN	NN	_	43	compound	_	_
40	)	)	-RRB-	-RRB-	_	43	punct	_	_
41	/Jun	/jun	NN	NN	_	43	compound	_	_
42	N-terminal	n-terminal	JJ	JJ	_	43	amod	_	_
43	kinase	kinase	NN	NN	_	25	conj	_	_
44	,	,	,	,	_	21	punct	_	_
45	but	but	CC	CC	_	46	cc	_	_
46	not	not	RB	RB	_	21	cc	_	_
47	with	with	IN	IN	_	49	case	_	_
48	the	the	DT	DT	_	49	det	_	_
49	activation	activation	NN	NN	_	21	conj	_	_
50	of	of	IN	IN	_	54	case	_	_
51	the	the	DT	DT	_	54	det	_	_
52	extracellular	extracellular	JJ	JJ	_	54	amod	_	_
53	signal-regulated	signal-regulated	JJ	JJ	_	54	amod	_	_
54	kinases	kinase	NNS	NNS	_	49	nmod	_	_
55	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	synergy	synergy	NN	NN	_	10	nsubjpass	_	_
4	between	between	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	IL-12	il-12	NN	NN	_	5	conj	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	prominent	prominent	JJ	JJ	_	14	amod	_	_
14	increase	increase	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	20	case	_	_
16	STAT1	stat1	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	STAT3	stat3	NN	NN	_	16	conj	_	_
19	serine	serine	NN	NN	_	20	compound	_	_
20	phosphorylation	phosphorylation	NN	NN	_	14	nmod	_	_
21	over	over	IN	IN	_	22	case	_	_
22	that	that	DT	DT	_	14	nmod	_	_
23	observed	observe	VBN	VBN	_	22	acl	_	_
24	with	with	IN	IN	_	25	case	_	_
25	IL-12	il-12	NN	NN	_	23	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	IL-2	il-2	NN	NN	_	25	conj	_	_
28	alone	alone	RB	RB	_	25	advmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	STAT	stat	NN	NN	_	6	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	9	nsubj	_	_
7	is	be	VBZ	VBZ	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	augmented	augmented	JJ	JJ	_	0	root	_	_
10	over	over	IN	IN	_	11	case	_	_
11	that	that	DT	DT	_	9	nmod	_	_
12	seen	see	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	either	either	DT	DT	_	15	det	_	_
15	cytokine	cytokine	NN	NN	_	12	nmod	_	_
16	alone	alone	RB	RB	_	15	advmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	specific	specific	JJ	JJ	_	3	amod	_	_
3	inhibitor	inhibitor	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	p38	p38	NN	NN	_	7	compound	_	_
6	MAP	map	NN	NN	_	7	compound	_	_
7	kinase	kinase	NN	NN	_	3	nmod	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	serine	serine	JJ	JJ	_	12	amod	_	_
12	phosphorylation	phosphorylation	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	STAT1	stat1	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	STAT3	stat3	NN	NN	_	14	conj	_	_
17	induced	induce	VBN	VBN	_	14	acl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	IL-12	il-12	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IL-2	il-2	NN	NN	_	19	conj	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	abrogates	abrogate	VBZ	VBZ	_	9	conj	_	_
24	the	the	DT	DT	_	26	det	_	_
25	functional	functional	JJ	JJ	_	26	amod	_	_
26	synergy	synergy	NN	NN	_	23	dobj	_	_
27	between	between	IN	IN	_	28	case	_	_
28	IL-12	il-12	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	IL-2	il-2	NN	NN	_	28	conj	_	_
31	without	without	IN	IN	_	32	mark	_	_
32	affecting	affect	VBG	VBG	_	23	advcl	_	_
33	STAT	stat	NN	NN	_	35	compound	_	_
34	tyrosine	tyrosine	NN	NN	_	35	compound	_	_
35	phosphorylation	phosphorylation	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	p38	p38	NN	NN	_	6	compound	_	_
5	MAP	map	NN	NN	_	6	compound	_	_
6	kinase	kinase	NN	NN	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	play	play	VB	VB	_	2	ccomp	_	_
9	an	a	DT	DT	_	11	det	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	regulating	regulate	VBG	VBG	_	8	advcl	_	_
14	STAT	stat	NN	NN	_	16	compound	_	_
15	serine	serine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	response	response	NN	NN	_	21	dep	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	combination	combination	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	IL-12	il-12	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	IL-2	il-2	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	optimal	optimal	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	18	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	IL-12	il-12	NN	NN	_	9	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-2	il-2	NN	NN	_	14	conj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	depend	depend	VB	VB	_	5	ccomp	_	_
19	on	on	IN	IN	_	21	case	_	_
20	an	a	DT	DT	_	21	det	_	_
21	interaction	interaction	NN	NN	_	18	nmod	_	_
22	between	between	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	p38	p38	NN	NN	_	26	compound	_	_
25	MAP	map	NN	NN	_	26	compound	_	_
26	kinase	kinase	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	Janus	janus	NN	NN	_	31	compound	_	_
29	kinase/STAT	kinase/stat	NN	NN	_	31	compound	_	_
30	signaling	signaling	NN	NN	_	31	compound	_	_
31	pathways	pathway	NNS	NNS	_	26	conj	_	_
32	.	.	.	.	_	5	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	cytomegalovirus	cytomegalovirus	NN	NN	_	7	nsubj	_	_
3	binding	bind	VBG	VBG	_	2	amod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	immunoregulatory	immunoregulatory	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	dobj	_	_
11	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	continue	continue	VB	VB	_	20	advcl	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	investigation	investigation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	events	event	NNS	NNS	_	4	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	occur	occur	VBP	VBP	_	8	acl:relcl	_	_
11	following	follow	VBG	VBG	_	17	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	CMV	cmv	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	HCMV	hcmv	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	infection	infection	NN	NN	_	10	nmod	_	_
18	,	,	,	,	_	20	punct	_	_
19	we	we	PRP	PRP	_	20	nsubj	_	_
20	focused	focus	VBD	VBD	_	0	root	_	_
21	on	on	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	regulation	regulation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	cellular	cellular	JJ	JJ	_	26	amod	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	following	follow	VBG	VBG	_	29	case	_	_
28	viral	viral	JJ	JJ	_	29	amod	_	_
29	binding	binding	NN	NN	_	26	nmod	_	_
30	to	to	TO	TO	_	32	case	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	monocytes	monocyte	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	20	punct	_	_

1	First	first	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	viral	viral	JJ	JJ	_	7	amod	_	_
7	binding	binding	NN	NN	_	8	nsubj	_	_
8	induced	induce	VBD	VBD	_	4	ccomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	number	number	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	immunoregulatory	immunoregulatory	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	IL-1beta	il-1beta	NN	NN	_	13	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	A20	a20	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	NF-kappaB-p105/p50	nf-kappab-p105/p50	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	15	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	IkappaBalpha	ikappabalpha	NN	NN	_	15	conj	_	_
23	)	)	-RRB-	-RRB-	_	15	punct	_	_
24	in	in	IN	IN	_	26	case	_	_
25	unactivated	unactivated	JJ	JJ	_	26	amod	_	_
26	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
27	and	and	CC	CC	_	8	cc	_	_
28	that	that	IN	IN	_	47	mark	_	_
29	neutralizing	neutralize	VBG	VBG	_	30	amod	_	_
30	Abs	ab	NNS	NNS	_	47	nsubj	_	_
31	to	to	TO	TO	_	35	case	_	_
32	the	the	DT	DT	_	35	det	_	_
33	major	major	JJ	JJ	_	35	amod	_	_
34	HCMV	hcmv	NN	NN	_	35	compound	_	_
35	glycoproteins	glycoprotein	NNS	NNS	_	30	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	gB	gb	NN	NN	_	35	appos	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	UL55	ul55	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	gH	gh	NN	NN	_	37	conj	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	UL75	ul75	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	,	,	,	,	_	35	punct	_	_
47	inhibited	inhibit	VBD	VBD	_	8	conj	_	_
48	the	the	DT	DT	_	49	det	_	_
49	induction	induction	NN	NN	_	47	dobj	_	_
50	of	of	IN	IN	_	52	case	_	_
51	these	these	DT	DT	_	52	det	_	_
52	genes	gene	NNS	NNS	_	49	nmod	_	_
53	.	.	.	.	_	4	punct	_	_

1	Next	next	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	these	these	DT	DT	_	8	det	_	_
7	viral	viral	JJ	JJ	_	8	amod	_	_
8	ligands	ligand	NNS	NNS	_	10	nsubj	_	_
9	directly	directly	RB	RB	_	10	advmod	_	_
10	up-regulated	up-regulate	VBD	VBD	_	4	ccomp	_	_
11	monocyte	monocyte	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	upon	upon	IN	IN	_	16	case	_	_
15	their	they	PRP$	PRP$	_	16	nmod:poss	_	_
16	binding	binding	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	21	case	_	_
18	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
19	appropriate	appropriate	JJ	JJ	_	21	amod	_	_
20	cellular	cellular	JJ	JJ	_	21	amod	_	_
21	receptors	receptor	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	then	then	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	if	if	IN	IN	_	8	mark	_	_
5	HCMV	hcmv	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	resulted	result	VBD	VBD	_	3	advcl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	translation	translation	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	secretion	secretion	NN	NN	_	11	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cytokines	cytokine	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	HCMV	hcmv	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	9	nsubj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	resulted	result	VBD	VBD	_	3	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	production	production	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	release	release	NN	NN	_	12	conj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IL-1beta	il-1beta	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Because	because	IN	IN	_	6	mark	_	_
2	these	these	DT	DT	_	5	det	_	_
3	induced	induce	VBN	VBN	_	5	amod	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	products	product	NNS	NNS	_	6	nsubj	_	_
6	have	have	VBP	VBP	_	16	advcl	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	sites	site	NNS	NNS	_	6	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	regions	region	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	next	next	RB	RB	_	16	advmod	_	_
16	examined	examine	VBD	VBD	_	0	root	_	_
17	whether	whether	IN	IN	_	19	mark	_	_
18	there	there	EX	EX	_	19	expl	_	_
19	was	be	VBD	VBD	_	16	ccomp	_	_
20	an	a	DT	DT	_	21	det	_	_
21	up-regulation	up-regulation	NN	NN	_	19	nsubj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	nuclear	nuclear	JJ	JJ	_	25	amod	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	25	compound	_	_
25	levels	level	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	,	,	,	,	_	11	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	fact	fact	NN	NN	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	translocated	translocate	VBN	VBN	_	3	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	nucleus	nucleus	NN	NN	_	11	nmod	_	_
15	following	follow	VBG	VBG	_	17	case	_	_
16	viral	viral	JJ	JJ	_	17	amod	_	_
17	binding	binding	NN	NN	_	11	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	purified	purify	VBN	VBN	_	22	amod	_	_
20	viral	viral	JJ	JJ	_	22	amod	_	_
21	ligand	ligand	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Changes	change	NNS	NNS	_	5	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	IkappaBalpha	ikappabalpha	NN	NN	_	4	compound	_	_
4	levels	level	NNS	NNS	_	1	nmod	_	_
5	correlated	correlate	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	changes	change	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	translocation	translocation	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Lastly	lastly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	p38	p38	NN	NN	_	8	compound	_	_
7	kinase	kinase	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	9	nsubj	_	_
9	played	play	VBD	VBD	_	4	ccomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	central	central	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	IL-1beta	il-1beta	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	it	it	PRP	PRP	_	21	nsubjpass	_	_
19	was	be	VBD	VBD	_	21	auxpass	_	_
20	rapidly	rapidly	RB	RB	_	21	advmod	_	_
21	up-regulated	up-regulate	VBN	VBN	_	9	conj	_	_
22	following	follow	VBG	VBG	_	23	case	_	_
23	infection	infection	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	HCMV	hcmv	NN	NN	_	8	nsubj	_	_
8	initiates	initiate	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	signal	signal	NN	NN	_	12	compound	_	_
11	transduction	transduction	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	8	dobj	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	leads	lead	VBZ	VBZ	_	12	acl:relcl	_	_
15	to	to	TO	TO	_	17	case	_	_
16	monocyte	monocyte	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	pinpoints	pinpoint	VBZ	VBZ	_	14	conj	_	_
20	a	a	DT	DT	_	22	det	_	_
21	potential	potential	JJ	JJ	_	22	amod	_	_
22	mechanism	mechanism	NN	NN	_	19	dobj	_	_
23	whereby	whereby	RB	RB	_	29	advmod	_	_
24	HCMV	hcmv	NN	NN	_	25	compound	_	_
25	infection	infection	NN	NN	_	29	nsubj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	monocytes	monocyte	NNS	NNS	_	25	nmod	_	_
28	can	can	MD	MD	_	29	aux	_	_
29	result	result	VB	VB	_	22	dep	_	_
30	in	in	IN	IN	_	32	case	_	_
31	profound	profound	JJ	JJ	_	32	amod	_	_
32	pathogenesis	pathogenesis	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	29	punct	_	_
34	especially	especially	RB	RB	_	38	advmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	chronic	chronic	JJ	JJ	_	38	amod	_	_
37	inflammatory-type	inflammatory-type	JJ	JJ	_	38	amod	_	_
38	conditions	condition	NNS	NNS	_	29	nmod	_	_
39	.	.	.	.	_	3	punct	_	_

1	Signal	signal	NN	NN	_	3	compound	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	0	root	_	_
4	activated	activate	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	endothelial	endothelial	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	following	follow	VBG	VBG	_	9	case	_	_
9	infection	infection	NN	NN	_	4	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	Chlamydia	chlamydia	NN	NN	_	9	nmod	_	_
12	pneumoniae	pneumoniae	FW	FW	_	11	dep	_	_
13	.	.	.	.	_	3	punct	_	_

1	Chlamydia	chlamydia	NN	NN	_	7	nsubj	_	_
2	pneumoniae	pneumoniae	FW	FW	_	1	dep	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	an	a	DT	DT	_	7	det	_	_
5	important	important	JJ	JJ	_	7	amod	_	_
6	respiratory	respiratory	JJ	JJ	_	7	amod	_	_
7	pathogen	pathogen	NN	NN	_	0	root	_	_
8	.	.	.	.	_	7	punct	_	_

1	Recently	recently	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	its	its	PRP$	PRP$	_	4	nmod:poss	_	_
4	presence	presence	NN	NN	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	atherosclerotic	atherosclerotic	JJ	JJ	_	10	amod	_	_
10	lesions	lesion	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	characterized	characterize	VBD	VBD	_	0	root	_	_
7	C.	c.	FW	FW	_	8	dep	_	_
8	pneumoniae-mediated	pneumoniae-mediated	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	demonstrated	demonstrate	VBD	VBD	_	6	conj	_	_
15	an	a	DT	DT	_	17	det	_	_
16	enhanced	enhance	VBN	VBN	_	17	amod	_	_
17	expression	expression	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	endothelial	endothelial	JJ	JJ	_	21	amod	_	_
20	adhesion	adhesion	NN	NN	_	21	compound	_	_
21	molecules	molecule	NNS	NNS	_	17	nmod	_	_
22	followed	follow	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	subsequent	subsequent	JJ	JJ	_	25	amod	_	_
25	rolling	rolling	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	adhesion	adhesion	NN	NN	_	25	conj	_	_
28	,	,	,	,	_	25	punct	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	transmigration	transmigration	NN	NN	_	25	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	leukocytes	leukocyte	NNS	NNS	_	25	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	monocytes	monocyte	NNS	NNS	_	32	appos	_	_
35	,	,	,	,	_	34	punct	_	_
36	granulocytes	granulocyte	NNS	NNS	_	34	dep	_	_
37	)	)	-RRB-	-RRB-	_	34	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	blocked	block	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	mAbs	mab	NNS	NNS	_	4	nmod	_	_
7	against	against	IN	IN	_	12	case	_	_
8	endothelial	endothelial	JJ	JJ	_	12	amod	_	_
9	and/or	and/or	CC	CC	_	8	cc	_	_
10	leukocyte	leukocyte	NN	NN	_	8	conj	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	beta1	beta1	NN	NN	_	17	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	beta2	beta2	NN	NN	_	14	conj	_	_
17	integrins	integrin	NNS	NNS	_	12	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	4	punct	_	_

1	Additionally	additionally	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	activation	activation	NN	NN	_	15	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	different	different	JJ	JJ	_	8	amod	_	_
6	signal	signal	NN	NN	_	8	compound	_	_
7	transduction	transduction	NN	NN	_	8	compound	_	_
8	pathways	pathway	NNS	NNS	_	3	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	C.	c.	FW	FW	_	13	compound	_	_
11	pneumoniae-infected	pneumoniae-infected	JJ	JJ	_	13	amod	_	_
12	endothelial	endothelial	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	3	nmod	_	_
14	was	be	VBD	VBD	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	0	root	_	_
16	:	:	:	:	_	15	punct	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
19	phosphorylation	phosphorylation	NN	NN	_	32	nsubj	_	_
20	,	,	,	,	_	19	punct	_	_
21	up-regulation	up-regulation	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	27	case	_	_
23	phosphorylated	phosphorylate	VBN	VBN	_	27	amod	_	_
24	p42/p44	p42/p44	NN	NN	_	27	compound	_	_
25	mitogen-activated	mitogen-activated	JJ	JJ	_	27	amod	_	_
26	protein	protein	NN	NN	_	27	compound	_	_
27	kinase	kinase	NN	NN	_	21	nmod	_	_
28	,	,	,	,	_	19	punct	_	_
29	and	and	CC	CC	_	19	cc	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	activation/translocation	activation/translocation	NN	NN	_	19	conj	_	_
32	occurred	occur	VBD	VBD	_	15	parataxis	_	_
33	within	within	IN	IN	_	35	case	_	_
34	10-15	10-15	CD	CD	_	35	nummod	_	_
35	min	min	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	15	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	mRNA	mrna	NN	NN	_	14	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	surface	surface	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	E-selectin	e-selectin	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	ICAM-1	icam-1	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	VCAM-1	vcam-1	NN	NN	_	7	conj	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	noted	note	VBN	VBN	_	0	root	_	_
15	within	within	IN	IN	_	16	case	_	_
16	hours	hour	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	14	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	C.	c.	FW	FW	_	4	compound	_	_
4	pneumoniae	pneumoniae	FW	FW	_	5	nsubj	_	_
5	triggers	trigger	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	cascade	cascade	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	events	event	NNS	NNS	_	7	nmod	_	_
10	that	that	WDT	WDT	_	12	nsubj	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	lead	lead	VB	VB	_	7	acl:relcl	_	_
13	to	to	TO	TO	_	15	case	_	_
14	endothelial	endothelial	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	inflammation	inflammation	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	thrombosis	thrombosis	NN	NN	_	15	conj	_	_
21	,	,	,	,	_	15	punct	_	_
22	which	which	WDT	WDT	_	26	nsubj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	turn	turn	NN	NN	_	26	nmod	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	result	result	VB	VB	_	15	acl:relcl	_	_
27	in	in	IN	IN	_	24	case	_	_
28	or	or	CC	CC	_	26	cc	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	promote	promote	VB	VB	_	26	conj	_	_
31	atherosclerosis	atherosclerosis	NN	NN	_	26	dobj	_	_
32	.	.	.	.	_	5	punct	_	_

1	Extracellular-regulated	extracellular-regulated	JJ	JJ	_	2	amod	_	_
2	kinase	kinase	NN	NN	_	12	nsubjpass	_	_
3	1/2	1/2	CD	CD	_	2	nummod	_	_
4	,	,	,	,	_	2	punct	_	_
5	Jun	jun	NN	NN	_	7	compound	_	_
6	N-terminal	n-terminal	JJ	JJ	_	7	amod	_	_
7	kinase	kinase	NN	NN	_	2	conj	_	_
8	,	,	,	,	_	2	punct	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	c-Jun	c-jun	NN	NN	_	2	conj	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	involved	involve	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	17	case	_	_
14	NF-kappa	nf-kappa	NN	NN	_	15	nmod:npmod	_	_
15	B-dependent	b-dependent	JJ	JJ	_	17	amod	_	_
16	IL-6	il-6	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	6	nmod	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigated	investigate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	possible	possible	JJ	JJ	_	9	amod	_	_
9	involvement	involvement	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	16	case	_	_
11	the	the	DT	DT	_	16	det	_	_
12	mitogen-activated	mitogen-activated	JJ	JJ	_	16	amod	_	_
13	protein	protein	NN	NN	_	16	compound	_	_
14	kinase	kinase	NN	NN	_	16	compound	_	_
15	family	family	NN	NN	_	16	compound	_	_
16	members	member	NNS	NNS	_	9	nmod	_	_
17	extracellular-regulated	extracellular-regulated	JJ	JJ	_	18	amod	_	_
18	kinase	kinase	NN	NN	_	16	dep	_	_
19	1/2	1/2	CD	CD	_	18	nummod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ERK1/2	erk1/2	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	18	cc	_	_
24	c-Jun	c-jun	NN	NN	_	26	compound	_	_
25	N-terminal	n-terminal	JJ	JJ	_	26	amod	_	_
26	kinase	kinase	NN	NN	_	18	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	JNK	jnk	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	in	in	IN	IN	_	31	case	_	_
31	mediating	mediate	VBG	VBG	_	9	acl	_	_
32	IL-6	il-6	NN	NN	_	34	compound	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	31	dobj	_	_
35	in	in	IN	IN	_	37	case	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	monocytes	monocyte	NNS	NNS	_	34	nmod	_	_
38	,	,	,	,	_	31	punct	_	_
39	in	in	IN	IN	_	40	case	_	_
40	particular	particular	JJ	JJ	_	42	nmod	_	_
41	their	they	PRP$	PRP$	_	42	nmod:poss	_	_
42	role	role	NN	NN	_	31	dep	_	_
43	in	in	IN	IN	_	44	mark	_	_
44	enhancing	enhance	VBG	VBG	_	42	acl	_	_
45	NF-kappa	nf-kappa	NN	NN	_	47	compound	_	_
46	B	b	NN	NN	_	47	compound	_	_
47	activity	activity	NN	NN	_	44	dobj	_	_
48	.	.	.	.	_	6	punct	_	_

1	Freshly	freshly	RB	RB	_	2	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	monocytes	monocyte	NNS	NNS	_	12	nsubj	_	_
4	treated	treat	VBN	VBN	_	3	acl	_	_
5	with	with	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	protein	protein	NN	NN	_	11	compound	_	_
8	phosphatase	phosphatase	NN	NN	_	11	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	11	compound	_	_
10	okadaic	okadaic	JJ	JJ	_	11	amod	_	_
11	acid	acid	NN	NN	_	4	nmod	_	_
12	secreted	secrete	VBD	VBD	_	0	root	_	_
13	high	high	JJ	JJ	_	14	amod	_	_
14	levels	level	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	IL-6	il-6	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	coincided	coincide	VBD	VBD	_	12	ccomp	_	_
21	with	with	IN	IN	_	24	case	_	_
22	enhanced	enhance	VBN	VBN	_	24	amod	_	_
23	binding	binding	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	NF-kappa	nf-kappa	NN	NN	_	27	compound	_	_
27	B	b	NN	NN	_	24	nmod	_	_
28	as	as	RB	RB	_	24	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	with	with	IN	IN	_	32	case	_	_
32	phosphorylation	phosphorylation	NN	NN	_	24	conj	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	activation	activation	NN	NN	_	32	conj	_	_
35	of	of	IN	IN	_	40	case	_	_
36	the	the	DT	DT	_	40	det	_	_
37	ERK1/2	erk1/2	NN	NN	_	40	compound	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	JNK	jnk	NN	NN	_	37	conj	_	_
40	proteins	protein	NNS	NNS	_	32	nmod	_	_
41	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	ERK	erk	NN	NN	_	3	nmod:npmod	_	_
3	pathway-specific	pathway-specific	JJ	JJ	_	5	amod	_	_
4	inhibitor	inhibitor	NN	NN	_	5	compound	_	_
5	PD98059	pd98059	NN	NN	_	6	nsubj	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	IL-6	il-6	NN	NN	_	8	compound	_	_
8	secretion	secretion	NN	NN	_	6	dobj	_	_
9	from	from	IN	IN	_	10	case	_	_
10	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	overexpression	overexpression	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	inactive	inactive	JJ	JJ	_	5	amod	_	_
5	mutants	mutant	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	either	either	CC	CC	_	8	cc:preconj	_	_
8	Raf-1	raf-1	NN	NN	_	5	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	JNK1	jnk1	NN	NN	_	8	conj	_	_
11	showed	show	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	both	both	DT	DT	_	14	det	_	_
14	pathways	pathway	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	11	ccomp	_	_
17	in	in	IN	IN	_	22	case	_	_
18	kappa	kappa	NN	NN	_	19	nmod:npmod	_	_
19	B-dependent	b-dependent	JJ	JJ	_	22	amod	_	_
20	IL-6	il-6	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	6	advcl	_	_
3	PD98059	pd98059	NN	NN	_	2	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Raf1/MEK1/ERK1/2	raf1/mek1/erk1/2	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	13	nsubj	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affect	affect	VB	VB	_	6	ccomp	_	_
14	the	the	DT	DT	_	16	det	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	binding	binding	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NF-kappa	nf-kappa	NN	NN	_	19	compound	_	_
19	B	b	NN	NN	_	16	nmod	_	_
20	but	but	CC	CC	_	13	cc	_	_
21	,	,	,	,	_	13	punct	_	_
22	rather	rather	RB	RB	_	13	advmod	_	_
23	,	,	,	,	_	13	punct	_	_
24	acted	act	VBD	VBD	_	13	dep	_	_
25	at	at	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	level	level	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	transcriptional	transcriptional	JJ	JJ	_	30	amod	_	_
30	activity	activity	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	NF-kappa	nf-kappa	NN	NN	_	33	compound	_	_
33	B	b	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Interestingly	interestingly	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	28	mark	_	_
7	NF-kappa	nf-kappa	NN	NN	_	8	nmod:npmod	_	_
8	B-mediated	b-mediated	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	transcription	transcription	NN	NN	_	28	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	both	both	DT	DT	_	19	dep	_	_
13	in	in	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	dep	_	_
15	context	context	NN	NN	_	19	dep	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-6	il-6	NN	NN	_	19	compound	_	_
19	promoter	promoter	NN	NN	_	10	nmod	_	_
20	as	as	RB	RB	_	19	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	on	on	IN	IN	_	25	case	_	_
24	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
25	own	own	JJ	JJ	_	19	conj	_	_
26	,	,	,	,	_	10	punct	_	_
27	was	be	VBD	VBD	_	28	cop	_	_
28	dependent	dependent	JJ	JJ	_	5	ccomp	_	_
29	on	on	IN	IN	_	33	case	_	_
30	both	both	CC	CC	_	33	cc:preconj	_	_
31	serine	serine	JJ	JJ	_	33	amod	_	_
32	kinase	kinase	NN	NN	_	33	compound	_	_
33	activity	activity	NN	NN	_	28	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	interaction	interaction	NN	NN	_	33	conj	_	_
36	with	with	IN	IN	_	38	case	_	_
37	c-Jun	c-jun	NN	NN	_	38	compound	_	_
38	protein	protein	NN	NN	_	35	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	okadaic	okadaic	JJ	JJ	_	5	amod	_	_
5	acid-induced	acid-induced	JJ	JJ	_	8	amod	_	_
6	IL-6	il-6	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	13	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	13	auxpass	_	_
10	at	at	IN	IN	_	12	advmod	_	_
11	least	least	JJS	JJS	_	10	mwe	_	_
12	partly	partly	RB	RB	_	13	advmod	_	_
13	mediated	mediate	VBN	VBN	_	2	ccomp	_	_
14	through	through	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	ERK1/2	erk1/2	NN	NN	_	19	dep	_	_
17	and	and	CC	CC	_	19	cc	_	_
18	JNK	jnk	NN	NN	_	19	conj	_	_
19	pathway-dependent	pathway-dependent	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	25	compound	_	_
23	B	b	NN	NN	_	25	compound	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	capacity	capacity	NN	NN	_	20	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	JNK	jnk	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	regulate	regulate	VB	VB	_	3	ccomp	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	nmod:npmod	_	_
11	B-mediated	b-mediated	JJ	JJ	_	13	amod	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	transcription	transcription	NN	NN	_	9	dobj	_	_
14	through	through	IN	IN	_	16	case	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	phosphorylation	phosphorylation	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activation	activation	NN	NN	_	16	conj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	c-Jun	c-jun	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	21	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	interferon	interferon	NN	NN	_	9	compound	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	IFN	ifn	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	-inducible	-inducible	JJ	JJ	_	9	amod	_	_
9	protein	protein	NN	NN	_	2	nmod	_	_
10	10	10	CD	CD	_	9	nummod	_	_
11	following	follow	VBG	VBG	_	12	case	_	_
12	differentiation	differentiation	NN	NN	_	2	nmod	_	_
13	of	of	IN	IN	_	19	case	_	_
14	a	a	DT	DT	_	19	det	_	_
15	monocyte	monocyte	NN	NN	_	19	compound	_	_
16	,	,	,	,	_	19	punct	_	_
17	macrophage	macrophage	NN	NN	_	19	dep	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lineage	lineage	NN	NN	_	12	nmod	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	related	related	JJ	JJ	_	0	root	_	_
22	to	to	TO	TO	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	changes	change	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	proteins	protein	NNS	NNS	_	24	nmod	_	_
28	bound	bind	VBN	VBN	_	27	acl	_	_
29	to	to	TO	TO	_	33	case	_	_
30	IFN	ifn	NN	NN	_	33	compound	_	_
31	stimulus	stimulus	NN	NN	_	33	compound	_	_
32	response	response	NN	NN	_	33	compound	_	_
33	element	element	NN	NN	_	28	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	kappaB	kappab	NN	NN	_	36	compound	_	_
36	sites	site	NNS	NNS	_	33	conj	_	_
37	.	.	.	.	_	21	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	chemokine	chemokine	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	following	follow	VBG	VBG	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	differentiation	differentiation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	15	case	_	_
10	a	a	DT	DT	_	15	det	_	_
11	monocyte	monocyte	NN	NN	_	15	compound	_	_
12	,	,	,	,	_	15	punct	_	_
13	macrophage	macrophage	NN	NN	_	15	dep	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lineage	lineage	NN	NN	_	8	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	human	human	JJ	JJ	_	5	amod	_	_
3	monoblastic	monoblastic	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	line	line	NN	NN	_	9	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	U937	u937	NN	NN	_	5	appos	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	differentiated	differentiate	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	treatment	treatment	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	either	either	CC	CC	_	19	cc:preconj	_	_
17	phorbol	phorbol	NN	NN	_	19	compound	_	_
18	12-myristate	12-myristate	NN	NN	_	19	compound	_	_
19	13-acetate	13-acetate	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	19	punct	_	_
24	retinoic	retinoic	JJ	JJ	_	25	amod	_	_
25	acid	acid	NN	NN	_	19	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	RA	ra	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	19	punct	_	_
30	or	or	CC	CC	_	19	cc	_	_
31	vitamin	vitamin	NN	NN	_	32	compound	_	_
32	D3	d3	NN	NN	_	19	conj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	VitD3	vitd3	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	22	nsubjpass	_	_
4	of	of	IN	IN	_	10	case	_	_
5	interferon	interferon	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	IFN	ifn	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	-inducible	-inducible	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	3	nmod	_	_
11	10	10	CD	CD	_	10	nummod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IP-10	ip-10	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	a	a	DT	DT	_	18	det	_	_
17	CXC	cxc	NN	NN	_	18	compound	_	_
18	chemokine	chemokine	NN	NN	_	10	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	was	be	VBD	VBD	_	22	auxpass	_	_
21	markedly	markedly	RB	RB	_	22	advmod	_	_
22	augmented	augment	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	IFNgamma	ifngamma	NN	NN	_	26	compound	_	_
26	treatment	treatment	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	PMA-	pma-	NN	NN	_	32	amod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	RA-differentiated	ra-differentiated	JJ	JJ	_	28	conj	_	_
31	U937	u937	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	22	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	but	but	CC	CC	_	32	cc	_	_
35	only	only	RB	RB	_	36	advmod	_	_
36	marginally	marginally	RB	RB	_	41	advmod	_	_
37	in	in	IN	IN	_	41	case	_	_
38	undifferentiated	undifferentiated	JJ	JJ	_	41	amod	_	_
39	or	or	CC	CC	_	38	cc	_	_
40	VitD3-treated	vitd3-treated	JJ	JJ	_	38	conj	_	_
41	cells	cell	NNS	NNS	_	32	conj	_	_
42	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	38	nmod	_	_
3	,	,	,	,	_	38	punct	_	_
4	another	another	DT	DT	_	7	det	_	_
5	inducible	inducible	JJ	JJ	_	7	amod	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	38	nsubjpass	_	_
8	of	of	IN	IN	_	11	case	_	_
9	monocyte	monocyte	NN	NN	_	11	compound	_	_
10	chemotactic	chemotactic	NN	NN	_	11	compound	_	_
11	protein-1	protein-1	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	a	a	DT	DT	_	15	det	_	_
14	CC	cc	NN	NN	_	15	compound	_	_
15	chemokine	chemokine	NN	NN	_	11	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	activation	activation	NN	NN	_	7	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	factor	factor	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	FcRFgamma	fcrfgamma	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	bound	bind	VBN	VBN	_	23	acl	_	_
28	to	to	TO	TO	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	gamma	gamma	NN	NN	_	32	compound	_	_
31	response	response	NN	NN	_	32	compound	_	_
32	region	region	NN	NN	_	27	nmod	_	_
33	were	be	VBD	VBD	_	38	auxpass	_	_
34	similarly	similarly	RB	RB	_	35	advmod	_	_
35	or	or	CC	CC	_	38	advmod	_	_
36	less	less	RBR	RBR	_	37	advmod	_	_
37	abundantly	abundantly	RB	RB	_	35	advmod	_	_
38	induced	induce	VBN	VBN	_	0	root	_	_
39	by	by	IN	IN	_	41	case	_	_
40	IFNgamma	ifngamma	NN	NN	_	41	compound	_	_
41	treatment	treatment	NN	NN	_	38	nmod	_	_
42	in	in	IN	IN	_	47	case	_	_
43	PMA-	pma-	NN	NN	_	47	amod	_	_
44	or	or	CC	CC	_	43	cc	_	_
45	RA-differentiated	ra-differentiated	JJ	JJ	_	43	conj	_	_
46	U937	u937	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	38	nmod	_	_
48	,	,	,	,	_	38	punct	_	_
49	indicating	indicate	VBG	VBG	_	38	xcomp	_	_
50	that	that	IN	IN	_	61	mark	_	_
51	increased	increase	VBN	VBN	_	54	amod	_	_
52	IP-10	ip-10	NN	NN	_	54	compound	_	_
53	mRNA	mrna	NN	NN	_	54	compound	_	_
54	induction	induction	NN	NN	_	61	nsubj	_	_
55	was	be	VBD	VBD	_	61	cop	_	_
56	not	not	RB	RB	_	61	neg	_	_
57	due	due	JJ	JJ	_	61	case	_	_
58	to	to	TO	TO	_	57	mwe	_	_
59	the	the	DT	DT	_	61	det	_	_
60	augmented	augmented	JJ	JJ	_	61	amod	_	_
61	ability	ability	NN	NN	_	49	ccomp	_	_
62	of	of	IN	IN	_	64	case	_	_
63	the	the	DT	DT	_	64	det	_	_
64	cells	cell	NNS	NNS	_	61	nmod	_	_
65	to	to	TO	TO	_	66	mark	_	_
66	respond	respond	VB	VB	_	61	acl	_	_
67	to	to	TO	TO	_	69	case	_	_
68	the	the	DT	DT	_	69	det	_	_
69	presence	presence	NN	NN	_	66	nmod	_	_
70	of	of	IN	IN	_	71	case	_	_
71	IFNgamma	ifngamma	NN	NN	_	69	nmod	_	_
72	.	.	.	.	_	38	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	IFNgamma-induced	ifngamma-induced	JJ	JJ	_	6	amod	_	_
5	IP-10	ip-10	NN	NN	_	6	compound	_	_
6	mRNA	mrna	NN	NN	_	2	nmod	_	_
7	following	follow	VBG	VBG	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	differentiation	differentiation	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	U937	u937	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	0	root	_	_
15	largely	largely	RB	RB	_	14	advmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	augmented	augmented	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	gene	gene	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	14	cc	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	related	related	JJ	JJ	_	14	conj	_	_
26	to	to	TO	TO	_	28	case	_	_
27	differentiation-dependent	differentiation-dependent	JJ	JJ	_	28	amod	_	_
28	changes	change	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	proteins	protein	NNS	NNS	_	28	nmod	_	_
32	bound	bind	VBN	VBN	_	31	acl	_	_
33	to	to	TO	TO	_	37	case	_	_
34	IFN	ifn	NN	NN	_	37	compound	_	_
35	stimulus	stimulus	NN	NN	_	37	compound	_	_
36	response	response	NN	NN	_	37	compound	_	_
37	element	element	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	ISRE	isre	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	and	and	CC	CC	_	37	cc	_	_
42	kB	kb	NN	NN	_	43	compound	_	_
43	sites	site	NNS	NNS	_	37	conj	_	_
44	,	,	,	,	_	14	punct	_	_
45	suggesting	suggest	VBG	VBG	_	14	advcl	_	_
46	that	that	IN	IN	_	51	mark	_	_
47	these	these	DT	DT	_	49	det	_	_
48	nuclear	nuclear	JJ	JJ	_	49	amod	_	_
49	proteins	protein	NNS	NNS	_	51	nsubj	_	_
50	may	may	MD	MD	_	51	aux	_	_
51	determine	determine	VB	VB	_	45	ccomp	_	_
52	the	the	DT	DT	_	55	det	_	_
53	IP-10	ip-10	NN	NN	_	55	compound	_	_
54	mRNA	mrna	NN	NN	_	55	compound	_	_
55	inducibility	inducibility	NN	NN	_	51	dobj	_	_
56	by	by	IN	IN	_	57	case	_	_
57	IFNgamma	ifngamma	NN	NN	_	55	nmod	_	_
58	.	.	.	.	_	14	punct	_	_

1	Fludarabine-induced	fludarabine-induced	JJ	JJ	_	2	amod	_	_
2	immunosuppression	immunosuppression	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	inhibition	inhibition	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	STAT1	stat1	NN	NN	_	9	compound	_	_
9	signaling	signaling	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	Fludarabine	fludarabine	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	nucleoside	nucleoside	JJ	JJ	_	5	amod	_	_
5	analog	analog	NN	NN	_	0	root	_	_
6	used	use	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	treatment	treatment	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	hematologic	hematologic	JJ	JJ	_	12	amod	_	_
12	malignancies	malignancy	NNS	NNS	_	9	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	induce	induce	VB	VB	_	12	acl:relcl	_	_
16	severe	severe	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	prolonged	prolonged	JJ	JJ	_	16	conj	_	_
19	immunosuppression	immunosuppression	NN	NN	_	15	dobj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	it	it	PRP	PRP	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	incorporated	incorporate	VBN	VBN	_	18	advcl	_	_
6	into	into	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	DNA	dna	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	dividing	divide	VBG	VBG	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	18	punct	_	_
13	fludarabine	fludarabine	NN	NN	_	18	nsubj	_	_
14	is	be	VBZ	VBZ	_	18	cop	_	_
15	also	also	RB	RB	_	18	advmod	_	_
16	a	a	DT	DT	_	18	det	_	_
17	potent	potent	JJ	JJ	_	18	amod	_	_
18	inhibitor	inhibitor	NN	NN	_	0	root	_	_
19	of	of	IN	IN	_	20	case	_	_
20	cells	cell	NNS	NNS	_	18	nmod	_	_
21	with	with	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	low	low	JJ	JJ	_	25	amod	_	_
24	growth	growth	NN	NN	_	25	compound	_	_
25	fraction	fraction	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	18	punct	_	_
27	thus	thus	RB	RB	_	18	advmod	_	_
28	it	it	PRP	PRP	_	30	nsubj	_	_
29	must	must	MD	MD	_	30	aux	_	_
30	have	have	VB	VB	_	18	parataxis	_	_
31	other	other	JJ	JJ	_	32	amod	_	_
32	mechanisms	mechanism	NNS	NNS	_	30	dobj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	action	action	NN	NN	_	32	nmod	_	_
35	.	.	.	.	_	18	punct	_	_

1	STAT1	stat1	NN	NN	_	17	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	which	which	WDT	WDT	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	activated	activate	VBN	VBN	_	1	acl:relcl	_	_
6	in	in	IN	IN	_	11	case	_	_
7	response	response	NN	NN	_	11	dep	_	_
8	to	to	TO	TO	_	11	case	_	_
9	many	many	JJ	JJ	_	11	amod	_	_
10	lymphocyte-activating	lymphocyte-activating	JJ	JJ	_	11	amod	_	_
11	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
12	including	include	VBG	VBG	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	interferons	interferon	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	1	punct	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	essential	essential	JJ	JJ	_	0	root	_	_
18	for	for	IN	IN	_	20	case	_	_
19	cell-mediated	cell-mediated	JJ	JJ	_	20	amod	_	_
20	immunity	immunity	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	as	as	IN	IN	_	29	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	absence	absence	NN	NN	_	29	nsubjpass	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	protein	protein	NN	NN	_	24	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	associated	associate	VBN	VBN	_	17	advcl	_	_
30	with	with	IN	IN	_	32	case	_	_
31	prominent	prominent	JJ	JJ	_	32	amod	_	_
32	defects	defect	NNS	NNS	_	29	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	ability	ability	NN	NN	_	32	nmod	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	control	control	VB	VB	_	35	acl	_	_
38	viral	viral	JJ	JJ	_	39	amod	_	_
39	infections	infection	NNS	NNS	_	37	dobj	_	_
40	.	.	.	.	_	17	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	fludarabine	fludarabine	NN	NN	_	14	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	8	cc	_	_
8	not	not	RB	RB	_	5	cc	_	_
9	the	the	DT	DT	_	12	det	_	_
10	immunosuppressant	immunosuppressant	JJ	JJ	_	12	amod	_	_
11	cyclosporine	cyclosporine	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	5	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	cytokine-induced	cytokine-induced	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	STAT1	stat1	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	STAT1-dependent	stat1-dependent	JJ	JJ	_	23	amod	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	transcription	transcription	NN	NN	_	17	conj	_	_
24	in	in	IN	IN	_	29	case	_	_
25	normal	normal	JJ	JJ	_	29	amod	_	_
26	resting	rest	VBG	VBG	_	29	amod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	activated	activate	VBN	VBN	_	26	conj	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	17	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Fludarabine	fludarabine	NN	NN	_	2	nsubj	_	_
2	caused	cause	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	depletion	depletion	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	STAT1	stat1	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	mRNA	mrna	NN	NN	_	8	conj	_	_
12	)	)	-RRB-	-RRB-	_	8	punct	_	_
13	but	but	CC	CC	_	14	cc	_	_
14	not	not	RB	RB	_	8	cc	_	_
15	of	of	IN	IN	_	17	case	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	STATs	stats	NNS	NNS	_	8	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	loss	loss	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT1	stat1	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	seen	see	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	cells	cell	NNS	NNS	_	7	nmod	_	_
10	from	from	IN	IN	_	11	case	_	_
11	patients	patient	NNS	NNS	_	9	nmod	_	_
12	treated	treat	VBN	VBN	_	11	acl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	fludarabine	fludarabine	NN	NN	_	12	nmod	_	_
15	in	in	FW	FW	_	16	compound	_	_
16	vivo	vivo	FW	FW	_	12	advmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Brief	brief	JJ	JJ	_	2	amod	_	_
2	exposure	exposure	NN	NN	_	5	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	fludarabine	fludarabine	NN	NN	_	2	nmod	_	_
5	led	lead	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	sustained	sustained	JJ	JJ	_	9	amod	_	_
9	loss	loss	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	STAT1	stat1	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	analogous	analogous	JJ	JJ	_	9	amod	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	prolonged	prolonged	JJ	JJ	_	17	amod	_	_
17	period	period	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	immunosuppression	immunosuppression	NN	NN	_	17	nmod	_	_
20	induced	induce	VBN	VBN	_	19	acl	_	_
21	by	by	IN	IN	_	22	case	_	_
22	exposure	exposure	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	drug	drug	NN	NN	_	22	nmod	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vivo	vivo	FW	FW	_	20	advmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	STAT1	stat1	NN	NN	_	8	nsubj	_	_
4	may	may	MD	MD	_	8	aux	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	useful	useful	JJ	JJ	_	8	amod	_	_
8	target	target	NN	NN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	development	development	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	new	new	JJ	JJ	_	17	amod	_	_
14	immunosuppressive	immunosuppressive	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	antineoplastic	antineoplastic	JJ	JJ	_	14	conj	_	_
17	agents	agent	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Suppressive	suppressive	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	anti-inflammatory	anti-inflammatory	JJ	JJ	_	5	amod	_	_
5	agents	agent	NNS	NNS	_	2	nmod	_	_
6	on	on	IN	IN	_	10	case	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	induction	induction	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	heat	heat	NN	NN	_	16	compound	_	_
15	shock	shock	NN	NN	_	16	compound	_	_
16	proteins	protein	NNS	NNS	_	12	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Studies	study	NNS	NNS	_	8	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	laboratory	laboratory	NN	NN	_	3	nmod	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	shown	show	VBN	VBN	_	1	appos	_	_
9	that	that	IN	IN	_	17	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	earliest	earliest	JJS	JJS	_	12	amod	_	_
12	stages	stage	NNS	NNS	_	17	nsubjpass	_	_
13	of	of	IN	IN	_	14	case	_	_
14	atherosclerosis	atherosclerosis	NN	NN	_	12	nmod	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	8	ccomp	_	_
18	by	by	IN	IN	_	21	case	_	_
19	an	a	DT	DT	_	21	det	_	_
20	autoimmune	autoimmune	JJ	JJ	_	21	amod	_	_
21	reaction	reaction	NN	NN	_	17	nmod	_	_
22	against	against	IN	IN	_	25	case	_	_
23	heat	heat	NN	NN	_	25	compound	_	_
24	shock	shock	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	21	nmod	_	_
26	60	60	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	Hsp60	hsp60	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interactions	interaction	NNS	NNS	_	14	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	Hsp60-specific	hsp60-specific	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	arterial	arterial	JJ	JJ	_	10	amod	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	2	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	EC	ec	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	require	require	VBP	VBP	_	0	root	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	Hsp60	hsp60	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	certain	certain	JJ	JJ	_	22	amod	_	_
21	adhesion	adhesion	NN	NN	_	22	compound	_	_
22	molecules	molecule	NNS	NNS	_	18	conj	_	_
23	shown	show	VBN	VBN	_	15	acl	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	induced	induce	VBN	VBN	_	23	xcomp	_	_
27	simultaneously	simultaneously	RB	RB	_	26	advmod	_	_
28	in	in	IN	IN	_	29	case	_	_
29	EC	ec	NN	NN	_	26	nmod	_	_
30	by	by	IN	IN	_	34	case	_	_
31	mechanical	mechanical	JJ	JJ	_	34	amod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	other	other	JJ	JJ	_	31	conj	_	_
34	types	type	NNS	NNS	_	26	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	stress	stress	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	14	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	suppression	suppression	NN	NN	_	19	nsubj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	T	t	NN	NN	_	10	nmod:npmod	_	_
10	cell-mediated	cell-mediated	JJ	JJ	_	12	amod	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	responses	response	NNS	NNS	_	7	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	cyclosporin	cyclosporin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	7	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	CyA	cya	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	enhanced	enhance	VBD	VBD	_	5	ccomp	_	_
20	atherosclerotic	atherosclerotic	JJ	JJ	_	22	amod	_	_
21	lesion	lesion	NN	NN	_	22	compound	_	_
22	formation	formation	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	mice	mouse	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	aspirin	aspirin	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	lower	lower	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	risk	risk	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	myocardial	myocardial	JJ	JJ	_	13	amod	_	_
13	infarction	infarction	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	men	man	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	conflicting	conflict	VBG	VBG	_	3	amod	_	_
3	observations	observation	NNS	NNS	_	9	nsubj	_	_
4	may	may	MD	MD	_	9	aux	_	_
5	be	be	VB	VB	_	9	cop	_	_
6	due	due	JJ	JJ	_	9	case	_	_
7	to	to	TO	TO	_	6	mwe	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	anti-inflammatory	anti-inflammatory	JJ	JJ	_	12	amod	_	_
12	agents	agent	NNS	NNS	_	9	nmod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	adhesion	adhesion	NN	NN	_	15	compound	_	_
15	molecule	molecule	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Hsp	hsp	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	EC	ec	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	respectively	respectively	RB	RB	_	15	advmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	MATERIAL	material	NN	NN	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	In	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	present	present	JJ	JJ	_	8	amod	_	_
8	study	study	NN	NN	_	11	nmod	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	analyzed	analyze	VBD	VBD	_	1	dep	_	_
12	the	the	DT	DT	_	13	det	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	CyA	cya	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	aspirin	aspirin	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	indomethacin	indomethacin	NN	NN	_	15	conj	_	_
21	on	on	IN	IN	_	24	case	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	proliferation	proliferation	NN	NN	_	13	nmod	_	_
25	using	use	VBG	VBG	_	11	xcomp	_	_
26	a	a	DT	DT	_	28	det	_	_
27	proliferation	proliferation	NN	NN	_	28	compound	_	_
28	assay	assay	NN	NN	_	25	dobj	_	_
29	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	explore	explore	VB	VB	_	32	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	adhesion	adhesion	NN	NN	_	7	compound	_	_
7	molecules	molecule	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	monocyte	monocyte	NN	NN	_	11	compound	_	_
10	chemoattractant	chemoattractant	NN	NN	_	11	compound	_	_
11	protein-1	protein-1	NN	NN	_	7	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	MCP-1	mcp-1	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	7	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	Hsp60	hsp60	NN	NN	_	7	conj	_	_
18	in	in	IN	IN	_	23	case	_	_
19	human	human	JJ	JJ	_	23	amod	_	_
20	umbilical	umbilical	JJ	JJ	_	23	amod	_	_
21	vein	vein	NN	NN	_	23	compound	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	4	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	HUVECs	huvec	NNS	NNS	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	32	punct	_	_
28	Northern	northern	NN	NN	_	30	compound	_	_
29	blot	blot	NN	NN	_	30	compound	_	_
30	analyses	analysis	NNS	NNS	_	32	nsubjpass	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	used	use	VBN	VBN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	examine	examine	VB	VB	_	29	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	activation	activation	NN	NN	_	5	compound	_	_
5	status	status	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	kappaB	kappab	NN	NN	_	9	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	heat	heat	NN	NN	_	19	compound	_	_
18	shock	shock	NN	NN	_	19	compound	_	_
19	factor-1	factor-1	NN	NN	_	12	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	HSF-1	hsf-1	NN	NN	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	29	punct	_	_
24	electrophoretic	electrophoretic	JJ	JJ	_	27	amod	_	_
25	mobility	mobility	NN	NN	_	27	compound	_	_
26	shift	shift	NN	NN	_	27	compound	_	_
27	assays	assay	NNS	NNS	_	29	nsubjpass	_	_
28	were	be	VBD	VBD	_	29	auxpass	_	_
29	performed	perform	VBN	VBN	_	0	root	_	_
30	.	.	.	.	_	29	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	With	with	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	exception	exception	NN	NN	_	16	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	indomethacin	indomethacin	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	16	punct	_	_
9	the	the	DT	DT	_	14	det	_	_
10	used	use	VBN	VBN	_	14	amod	_	_
11	immunosuppressive	immunosuppressive	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	anti-inflammatory	anti-inflammatory	JJ	JJ	_	11	conj	_	_
14	agents	agent	NNS	NNS	_	16	nsubj	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	inhibited	inhibit	VBD	VBD	_	1	appos	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	proliferation	proliferation	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	25	case	_	_
21	response	response	NN	NN	_	25	dep	_	_
22	to	to	TO	TO	_	25	case	_	_
23	influenza	influenza	NN	NN	_	25	compound	_	_
24	virus	virus	NN	NN	_	25	compound	_	_
25	antigen	antigen	NN	NN	_	16	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	dose-dependent	dose-dependent	JJ	JJ	_	29	amod	_	_
29	manner	manner	NN	NN	_	16	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	Interestingly	interestingly	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	CyA	cya	NN	NN	_	8	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	indomethacin	indomethacin	NN	NN	_	3	conj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	suppress	suppress	VB	VB	_	0	root	_	_
9	tumor	tumor	NN	NN	_	15	nmod:npmod	_	_
10	necrosis	necrosis	NN	NN	_	15	nmod:npmod	_	_
11	factor-alpha	factor-alpha	NN	NN	_	15	nmod:npmod	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	15	nmod:npmod	_	_
14	)	)	-RRB-	-RRB-	_	15	punct	_	_
15	-induced	-induced	JJ	JJ	_	18	amod	_	_
16	adhesion	adhesion	NN	NN	_	18	compound	_	_
17	molecule	molecule	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	8	dobj	_	_
19	on	on	IN	IN	_	20	case	_	_
20	HUVECs	huvec	NNS	NNS	_	18	nmod	_	_
21	,	,	,	,	_	8	punct	_	_
22	whereas	whereas	IN	IN	_	8	dep	_	_
23	aspirin	aspirin	NN	NN	_	24	nsubj	_	_
24	had	have	VBD	VBD	_	8	parataxis	_	_
25	an	a	DT	DT	_	27	det	_	_
26	inhibitory	inhibitory	JJ	JJ	_	27	amod	_	_
27	effect	effect	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	correlated	correlate	VBD	VBD	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	modulation	modulation	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	EC	ec	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	agents	agent	NNS	NNS	_	4	nsubj	_	_
3	tested	test	VBN	VBN	_	2	acl	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Hsp60	hsp60	NN	NN	_	5	nmod	_	_
8	6	6	CD	CD	_	9	nummod	_	_
9	hr	hr	NN	NN	_	4	nmod	_	_
10	after	after	IN	IN	_	9	case	_	_
11	application	application	NN	NN	_	9	dep	_	_
12	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	aspirin	aspirin	NN	NN	_	12	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	indomethacin	indomethacin	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	but	but	CC	CC	_	9	cc	_	_
9	not	not	RB	RB	_	4	cc	_	_
10	CyA	cya	NN	NN	_	4	conj	_	_
11	,	,	,	,	_	4	punct	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	Hsp70	hsp70	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	HUVECs	huvec	NNS	NNS	_	12	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	correlated	correlate	VBD	VBD	_	16	acl:relcl	_	_
19	with	with	IN	IN	_	20	case	_	_
20	induction	induction	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	HSF-1	hsf-1	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	1	appos	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	tested	test	VBN	VBN	_	9	amod	_	_
9	agents	agent	NNS	NNS	_	15	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	9	punct	_	_
11	except	except	IN	IN	_	12	case	_	_
12	indomethacin	indomethacin	NN	NN	_	9	nmod	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	inhibitors	inhibitor	NNS	NNS	_	5	ccomp	_	_
16	of	of	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	T	t	NN	NN	_	19	nmod:npmod	_	_
19	cell-mediated	cell-mediated	JJ	JJ	_	21	amod	_	_
20	immune	immune	JJ	JJ	_	21	amod	_	_
21	response	response	NN	NN	_	15	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	expected	expect	VBN	VBN	_	15	advcl	_	_
25	,	,	,	,	_	15	punct	_	_
26	that	that	IN	IN	_	31	mark	_	_
27	aspirin	aspirin	NN	NN	_	31	nsubj	_	_
28	is	be	VBZ	VBZ	_	31	cop	_	_
29	an	a	DT	DT	_	31	det	_	_
30	effective	effective	JJ	JJ	_	31	amod	_	_
31	suppressor	suppressor	NN	NN	_	15	conj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	adhesion	adhesion	NN	NN	_	35	compound	_	_
34	molecule	molecule	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	31	nmod	_	_
36	,	,	,	,	_	15	punct	_	_
37	and	and	CC	CC	_	15	cc	_	_
38	that	that	IN	IN	_	43	mark	_	_
39	all	all	DT	DT	_	41	det	_	_
40	three	three	CD	CD	_	41	nummod	_	_
41	agents	agent	NNS	NNS	_	43	nsubj	_	_
42	can	can	MD	MD	_	43	aux	_	_
43	induce	induce	VB	VB	_	15	conj	_	_
44	Hsp60	hsp60	NN	NN	_	43	dobj	_	_
45	in	in	IN	IN	_	46	case	_	_
46	HUVECs	huvec	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	basis	basis	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	notion	notion	NN	NN	_	6	nmod	_	_
10	that	that	IN	IN	_	26	mark	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	1	1	LS	LS	_	26	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	part	part	NN	NN	_	26	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	anti-atherogenic	anti-atherogenic	JJ	JJ	_	18	amod	_	_
18	effect	effect	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	aspirin	aspirin	NN	NN	_	18	nmod	_	_
21	may	may	MD	MD	_	26	aux	_	_
22	be	be	VB	VB	_	26	cop	_	_
23	due	due	JJ	JJ	_	26	case	_	_
24	to	to	TO	TO	_	23	mwe	_	_
25	the	the	DT	DT	_	26	det	_	_
26	prevention	prevention	NN	NN	_	9	ccomp	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	adhesion	adhesion	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	sensitized	sensitize	VBN	VBN	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	stressed	stressed	JJ	JJ	_	36	amod	_	_
36	EC	ec	NN	NN	_	29	nmod	_	_
37	;	;	:	:	_	26	punct	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	2	2	LS	LS	_	54	dep	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	that	that	IN	IN	_	54	mark	_	_
42	part	part	NN	NN	_	54	nsubj	_	_
43	of	of	IN	IN	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	atherosclerosis-promoting	atherosclerosis-promoting	JJ	JJ	_	46	amod	_	_
46	effect	effect	NN	NN	_	42	nmod	_	_
47	of	of	IN	IN	_	48	case	_	_
48	CyA	cya	NN	NN	_	46	nmod	_	_
49	may	may	MD	MD	_	54	aux	_	_
50	be	be	VB	VB	_	54	cop	_	_
51	due	due	JJ	JJ	_	54	case	_	_
52	to	to	TO	TO	_	51	mwe	_	_
53	its	its	PRP$	PRP$	_	54	nmod:poss	_	_
54	potential	potential	NN	NN	_	26	conj	_	_
55	as	as	IN	IN	_	57	case	_	_
56	an	a	DT	DT	_	57	det	_	_
57	inducer	inducer	NN	NN	_	54	nmod	_	_
58	of	of	IN	IN	_	60	case	_	_
59	Hsp60	hsp60	NN	NN	_	60	compound	_	_
60	expression	expression	NN	NN	_	57	nmod	_	_
61	and	and	CC	CC	_	54	cc	_	_
62	its	its	PRP$	PRP$	_	63	nmod:poss	_	_
63	inability	inability	NN	NN	_	54	conj	_	_
64	to	to	TO	TO	_	65	mark	_	_
65	down-regulate	down-regulate	VB	VB	_	63	acl	_	_
66	adhesion	adhesion	NN	NN	_	68	compound	_	_
67	molecule	molecule	NN	NN	_	68	compound	_	_
68	expression	expression	NN	NN	_	65	dobj	_	_
69	on	on	IN	IN	_	70	case	_	_
70	EC	ec	NN	NN	_	68	nmod	_	_
71	;	;	:	:	_	26	punct	_	_
72	and	and	CC	CC	_	26	cc	_	_
73	(	(	-LRB-	-LRB-	_	74	punct	_	_
74	3	3	LS	LS	_	84	dep	_	_
75	)	)	-RRB-	-RRB-	_	74	punct	_	_
76	that	that	IN	IN	_	84	mark	_	_
77	down-regulation	down-regulation	NN	NN	_	84	nsubj	_	_
78	of	of	IN	IN	_	80	case	_	_
79	MCP-1	mcp-1	NN	NN	_	80	compound	_	_
80	expression	expression	NN	NN	_	77	nmod	_	_
81	by	by	IN	IN	_	82	case	_	_
82	aspirin	aspirin	NN	NN	_	77	nmod	_	_
83	may	may	MD	MD	_	84	aux	_	_
84	result	result	VB	VB	_	26	conj	_	_
85	in	in	IN	IN	_	87	case	_	_
86	decreased	decrease	VBN	VBN	_	87	amod	_	_
87	recruitment	recruitment	NN	NN	_	84	nmod	_	_
88	of	of	IN	IN	_	89	case	_	_
89	monocytes	monocyte	NNS	NNS	_	87	nmod	_	_
90	into	into	IN	IN	_	93	case	_	_
91	the	the	DT	DT	_	93	det	_	_
92	arterial	arterial	JJ	JJ	_	93	amod	_	_
93	intima	intima	NN	NN	_	87	nmod	_	_
94	beneath	beneath	IN	IN	_	96	case	_	_
95	stressed	stressed	JJ	JJ	_	96	amod	_	_
96	EC	ec	NN	NN	_	93	nmod	_	_
97	.	.	.	.	_	3	punct	_	_

1	Amelioration	amelioration	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	rat	rat	NN	NN	_	5	compound	_	_
4	cerulein	cerulein	NN	NN	_	5	compound	_	_
5	pancreatitis	pancreatitis	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	8	case	_	_
7	guamerin-derived	guamerin-derived	JJ	JJ	_	8	amod	_	_
8	peptide	peptide	NN	NN	_	1	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	13	det	_	_
11	novel	novel	JJ	JJ	_	13	amod	_	_
12	elastase	elastase	NN	NN	_	13	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	8	appos	_	_
14	.	.	.	.	_	1	punct	_	_

1	Increased	increase	VBN	VBN	_	2	amod	_	_
2	activity	activity	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	various	various	JJ	JJ	_	5	amod	_	_
5	proteases	protease	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	13	case	_	_
9	both	both	CC	CC	_	10	cc:preconj	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	experimental	experimental	JJ	JJ	_	10	conj	_	_
13	pancreatitis	pancreatitis	NN	NN	_	7	nmod	_	_
14	;	;	:	:	_	7	punct	_	_
15	however	however	RB	RB	_	30	advmod	_	_
16	,	,	,	,	_	30	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	information	information	NN	NN	_	30	nsubj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	effects	effect	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	protease	protease	NN	NN	_	25	compound	_	_
25	inhibitors	inhibitor	NNS	NNS	_	21	nmod	_	_
26	on	on	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	disease	disease	NN	NN	_	21	nmod	_	_
29	is	be	VBZ	VBZ	_	30	cop	_	_
30	limited	limited	JJ	JJ	_	7	parataxis	_	_
31	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	a	a	DT	DT	_	10	det	_	_
8	novel	novel	JJ	JJ	_	10	amod	_	_
9	elastase	elastase	NN	NN	_	10	compound	_	_
10	inhibitor	inhibitor	NN	NN	_	19	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	guamerin-derived	guamerin-derived	JJ	JJ	_	14	amod	_	_
13	synthetic	synthetic	JJ	JJ	_	14	amod	_	_
14	peptide	peptide	NN	NN	_	10	appos	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	GDSP	gdsp	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	19	punct	_	_
19	improves	improve	VBZ	VBZ	_	5	ccomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	parameters	parameter	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	cerulein-induced	cerulein-induced	JJ	JJ	_	25	amod	_	_
24	acute	acute	JJ	JJ	_	25	amod	_	_
25	pancreatitis	pancreatitis	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	rat	rat	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	32	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GDSP	gdsp	NN	NN	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	pancreatic	pancreatic	JJ	JJ	_	7	amod	_	_
7	weight	weight	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	serum	serum	NN	NN	_	10	compound	_	_
10	amylase	amylase	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	lipase	lipase	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	7	punct	_	_
14	morphologic	morphologic	JJ	JJ	_	15	amod	_	_
15	changes	change	NNS	NNS	_	7	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	pancreas	pancreas	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	neutrophil	neutrophil	NN	NN	_	21	compound	_	_
21	infiltration	infiltration	NN	NN	_	7	conj	_	_
22	,	,	,	,	_	7	punct	_	_
23	and	and	CC	CC	_	7	cc	_	_
24	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
25	factor	factor	NN	NN	_	30	compound	_	_
26	KB	kb	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	NF-KB	nf-kb	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	activation	activation	NN	NN	_	7	conj	_	_
31	were	be	VBD	VBD	_	32	auxpass	_	_
32	measured	measure	VBN	VBN	_	0	root	_	_
33	in	in	IN	IN	_	34	case	_	_
34	rats	rat	NNS	NNS	_	32	nmod	_	_
35	infused	infuse	VBN	VBN	_	34	acl	_	_
36	with	with	IN	IN	_	38	case	_	_
37	supramaximal	supramaximal	JJ	JJ	_	38	amod	_	_
38	dose	dose	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	cerulein	cerulein	NN	NN	_	38	nmod	_	_
41	(	(	-LRB-	-LRB-	_	44	punct	_	_
42	5	5	CD	CD	_	44	nummod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	g/kg/h	g/kg/h	NN	NN	_	38	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	for	for	IN	IN	_	48	case	_	_
47	6	6	CD	CD	_	48	nummod	_	_
48	h	h	NN	NN	_	35	nmod	_	_
49	.	.	.	.	_	32	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GDSP	gdsp	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	measured	measure	VBN	VBN	_	0	root	_	_
8	on	on	IN	IN	_	10	case	_	_
9	superoxide	superoxide	NN	NN	_	10	compound	_	_
10	formation	formation	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	activated	activate	VBN	VBN	_	14	amod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	neutrophils	neutrophil	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	GDSP	gdsp	NN	NN	_	2	nmod	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	compared	compare	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	8	case	_	_
8	those	those	DT	DT	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	another	another	DT	DT	_	12	det	_	_
11	elastase	elastase	NN	NN	_	12	compound	_	_
12	inhibitor	inhibitor	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	elastatinal	elastatinal	JJ	JJ	_	12	appos	_	_
15	.	.	.	.	_	6	punct	_	_

1	GDSP	gdsp	NN	NN	_	3	nsubj	_	_
2	significantly	significantly	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	19	dep	_	_
4	edema	edema	NN	NN	_	5	compound	_	_
5	formation	formation	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	infiltration	infiltration	NN	NN	_	5	conj	_	_
9	,	,	,	,	_	5	punct	_	_
10	acinar	acinar	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	damage	damage	NN	NN	_	5	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	plasma	plasma	NN	NN	_	16	compound	_	_
16	lipase	lipase	NN	NN	_	5	conj	_	_
17	and	and	CC	CC	_	19	cc	_	_
18	amylase	amylase	NN	NN	_	19	conj	_	_
19	increases	increase	NNS	NNS	_	0	root	_	_
20	caused	cause	VBN	VBN	_	19	dep	_	_
21	by	by	IN	IN	_	22	case	_	_
22	cerulein	cerulein	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	19	punct	_	_

1	GDSP	gdsp	NN	NN	_	4	nsubj	_	_
2	also	also	RB	RB	_	4	advmod	_	_
3	completely	completely	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	superoxide	superoxide	NN	NN	_	6	compound	_	_
6	formation	formation	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	neutrophils	neutrophil	NNS	NNS	_	6	nmod	_	_
11	stimulated	stimulate	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	N-formyl-methionine-leucine-phenyl-alanine	n-formyl-methionine-leucine-phenyl-alanine	NN	NN	_	11	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	fMLP	fmlp	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	or	or	CC	CC	_	13	cc	_	_
18	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	13	conj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TPA	tpa	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	4	punct	_	_

1	Elastatinal	elastatinal	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	some	some	DT	DT	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	same	same	JJ	JJ	_	7	amod	_	_
7	effects	effect	NNS	NNS	_	3	nmod	_	_
8	as	as	IN	IN	_	9	case	_	_
9	GDSP	gdsp	NN	NN	_	7	nmod	_	_
10	but	but	CC	CC	_	2	cc	_	_
11	was	be	VBD	VBD	_	13	cop	_	_
12	less	less	JJR	JJR	_	13	dep	_	_
13	potent	potent	JJ	JJ	_	2	conj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	effective	effective	JJ	JJ	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	beneficial	beneficial	JJ	JJ	_	6	amod	_	_
6	effect	effect	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	GDSP	gdsp	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	14	det	_	_
11	novel	novel	JJ	JJ	_	14	amod	_	_
12	specific	specific	JJ	JJ	_	14	amod	_	_
13	elastase	elastase	NN	NN	_	14	compound	_	_
14	inhibitor	inhibitor	NN	NN	_	8	appos	_	_
15	,	,	,	,	_	6	punct	_	_
16	on	on	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	development	development	NN	NN	_	6	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	rat	rat	NN	NN	_	22	compound	_	_
21	cerulein	cerulein	NN	NN	_	22	compound	_	_
22	pancreatitis	pancreatitis	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	signaling	signaling	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	12	case	_	_
7	mitogen-activated	mitogen-activated	JJ	JJ	_	9	amod	_	_
8	protein	protein	NN	NN	_	9	nmod:npmod	_	_
9	kinase-targeted	kinase-targeted	JJ	JJ	_	12	amod	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	12	amod	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphatase	phosphatase	NN	NN	_	5	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	HePTP	heptp	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	1	punct	_	_

1	Activation	activation	NN	NN	_	9	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	produce	produce	VB	VB	_	4	dep	_	_
7	cytokines	cytokine	NNS	NNS	_	6	dobj	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	counterbalance	counterbalance	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	protein-tyrosine	protein-tyrosine	JJ	JJ	_	15	amod	_	_
15	kinases	kinase	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	protein-tyrosine	protein-tyrosine	JJ	JJ	_	18	amod	_	_
18	phosphatases	phosphatase	NNS	NNS	_	15	conj	_	_
19	,	,	,	,	_	15	punct	_	_
20	many	many	JJ	JJ	_	23	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	20	nmod	_	_
23	have	have	VBP	VBP	_	15	acl:relcl	_	_
24	a	a	DT	DT	_	26	det	_	_
25	high	high	JJ	JJ	_	26	amod	_	_
26	degree	degree	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	substrate	substrate	JJ	JJ	_	29	amod	_	_
29	specificity	specificity	NN	NN	_	26	nmod	_	_
30	because	because	IN	IN	_	33	case	_	_
31	of	of	IN	IN	_	33	case	_	_
32	physical	physical	JJ	JJ	_	33	amod	_	_
33	association	association	NN	NN	_	23	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	their	they	PRP$	PRP$	_	36	nmod:poss	_	_
36	targets	target	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	Overexpression	overexpression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	hematopoietic	hematopoietic	JJ	JJ	_	5	amod	_	_
4	protein-tyrosine	protein-tyrosine	JJ	JJ	_	5	amod	_	_
5	phosphatase	phosphatase	NN	NN	_	1	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HePTP	heptp	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	11	case	_	_
11	suppression	suppression	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	as	as	IN	IN	_	17	case	_	_
17	measured	measure	VBN	VBN	_	9	advcl	_	_
18	by	by	IN	IN	_	23	case	_	_
19	T	t	NN	NN	_	23	compound	_	_
20	cell	cell	NN	NN	_	23	compound	_	_
21	antigen	antigen	NN	NN	_	23	compound	_	_
22	receptor-induced	receptor-induced	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	transcription	transcription	NN	NN	_	26	compound	_	_
26	factors	factor	NNS	NNS	_	23	nmod	_	_
27	binding	bind	VBG	VBG	_	26	acl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	5'	5'	JJ	JJ	_	31	amod	_	_
31	promoter	promoter	NN	NN	_	27	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	interleukin-2	interleukin-2	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	Efforts	effort	NNS	NNS	_	17	nsubj	_	_
2	to	to	TO	TO	_	3	mark	_	_
3	pinpoint	pinpoint	VB	VB	_	1	acl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	exact	exact	JJ	JJ	_	6	amod	_	_
6	site	site	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	action	action	NN	NN	_	6	acl	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	specificity	specificity	NN	NN	_	6	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HePTP	heptp	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	cascade	cascade	NN	NN	_	6	nmod	_	_
17	revealed	reveal	VBD	VBD	_	0	root	_	_
18	that	that	IN	IN	_	20	mark	_	_
19	HePTP	heptp	NN	NN	_	20	nsubj	_	_
20	acts	act	VBZ	VBZ	_	17	ccomp	_	_
21	directly	directly	RB	RB	_	20	advmod	_	_
22	on	on	IN	IN	_	29	case	_	_
23	the	the	DT	DT	_	29	det	_	_
24	mitogen-activated	mitogen-activated	JJ	JJ	_	25	amod	_	_
25	protein	protein	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	MAP	map	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	kinases	kinase	NNS	NNS	_	21	nmod	_	_
30	Erk1	erk1	NN	NN	_	29	dep	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	2	2	CD	CD	_	30	conj	_	_
33	and	and	CC	CC	_	20	cc	_	_
34	consequently	consequently	RB	RB	_	35	advmod	_	_
35	reduces	reduce	VBZ	VBZ	_	20	conj	_	_
36	the	the	DT	DT	_	37	dep	_	_
37	magnitude	magnitude	NN	NN	_	35	dobj	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	duration	duration	NN	NN	_	37	conj	_	_
40	of	of	IN	IN	_	43	case	_	_
41	their	they	PRP$	PRP$	_	43	nmod:poss	_	_
42	catalytic	catalytic	JJ	JJ	_	43	amod	_	_
43	activation	activation	NN	NN	_	37	nmod	_	_
44	in	in	IN	IN	_	47	case	_	_
45	intact	intact	JJ	JJ	_	47	amod	_	_
46	T	t	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	35	nmod	_	_
48	.	.	.	.	_	17	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	advcl	_	_
3	,	,	,	,	_	5	punct	_	_
4	HePTP	heptp	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
10	c-Jun	c-jun	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	7	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	on	on	IN	IN	_	14	case	_	_
14	events	event	NNS	NNS	_	11	conj	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	MAP	map	NN	NN	_	19	compound	_	_
19	kinases	kinase	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	specificity	specificity	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HePTP	heptp	NN	NN	_	2	nmod	_	_
5	correlated	correlate	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	its	its	PRP$	PRP$	_	9	nmod:poss	_	_
8	physical	physical	JJ	JJ	_	9	amod	_	_
9	association	association	NN	NN	_	5	nmod	_	_
10	through	through	IN	IN	_	14	case	_	_
11	its	its	PRP$	PRP$	_	14	dep	_	_
12	noncatalytic	noncatalytic	JJ	JJ	_	14	case	_	_
13	N	n	NN	NN	_	14	compound	_	_
14	terminus	terminus	NN	NN	_	9	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	Erk	erk	NN	NN	_	9	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	another	another	DT	DT	_	20	det	_	_
19	MAP	map	NN	NN	_	20	compound	_	_
20	kinase	kinase	NN	NN	_	16	conj	_	_
21	,	,	,	,	_	20	punct	_	_
22	p38	p38	NN	NN	_	20	appos	_	_
23	,	,	,	,	_	16	punct	_	_
24	but	but	CC	CC	_	16	cc	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	Jnk	jnk	NN	NN	_	16	conj	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	other	other	JJ	JJ	_	29	amod	_	_
29	proteins	protein	NNS	NNS	_	26	conj	_	_
30	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	HePTP	heptp	NN	NN	_	5	nsubj	_	_
5	plays	play	VBZ	VBZ	_	2	ccomp	_	_
6	a	a	DT	DT	_	8	det	_	_
7	negative	negative	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	antigen	antigen	NN	NN	_	12	compound	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	15	mark	_	_
14	specifically	specifically	RB	RB	_	15	advmod	_	_
15	regulating	regulate	VBG	VBG	_	5	advcl	_	_
16	MAP	map	NN	NN	_	17	compound	_	_
17	kinases	kinase	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cytosol	cytosol	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	at	at	IN	IN	_	25	case	_	_
23	early	early	JJ	JJ	_	25	amod	_	_
24	time	time	NN	NN	_	25	compound	_	_
25	points	point	NNS	NNS	_	20	conj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	T	t	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	25	nmod	_	_
30	before	before	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	activation-induced	activation-induced	JJ	JJ	_	33	amod	_	_
33	expression	expression	NN	NN	_	29	nmod	_	_
34	of	of	IN	IN	_	39	case	_	_
35	nuclear	nuclear	JJ	JJ	_	39	amod	_	_
36	dual-specific	dual-specific	JJ	JJ	_	39	amod	_	_
37	MAP	map	NN	NN	_	39	compound	_	_
38	kinase	kinase	NN	NN	_	39	compound	_	_
39	phosphatases	phosphatase	NNS	NNS	_	33	nmod	_	_
40	.	.	.	.	_	2	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	E2F	e2f	NN	NN	_	4	compound	_	_
4	complexes	complex	NNS	NNS	_	1	nmod	_	_
5	during	during	IN	IN	_	10	case	_	_
6	G0	g0	NN	NN	_	10	compound	_	_
7	to	to	TO	TO	_	6	dep	_	_
8	S	s	NN	NN	_	6	dep	_	_
9	phase	phase	NN	NN	_	10	compound	_	_
10	transition	transition	NN	NN	_	1	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	primary	primary	JJ	JJ	_	14	amod	_	_
14	B-lymphocytes	b-lymphocyte	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	pocket	pocket	NN	NN	_	4	compound	_	_
3	protein-E2F	protein-e2f	JJ	JJ	_	4	amod	_	_
4	complexes	complex	NNS	NNS	_	7	nsubj	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	convergence	convergence	NN	NN	_	7	compound	_	_
7	points	point	NNS	NNS	_	0	root	_	_
8	for	for	IN	IN	_	11	case	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	cycle	cycle	NN	NN	_	11	compound	_	_
11	signaling	signaling	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	report	report	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	identified	identify	VBD	VBD	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	monitored	monitor	VBD	VBD	_	7	conj	_	_
10	the	the	DT	DT	_	13	det	_	_
11	pocket	pocket	NN	NN	_	13	compound	_	_
12	protein-E2F	protein-e2f	JJ	JJ	_	13	amod	_	_
13	complexes	complex	NNS	NNS	_	7	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	B-lymphocytes	b-lymphocyte	NNS	NNS	_	13	nmod	_	_
18	after	after	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	7	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	phorbol	phorbol	NN	NN	_	23	compound	_	_
22	12-myristate	12-myristate	NN	NN	_	23	compound	_	_
23	13-acetate	13-acetate	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Consistent	consistent	JJ	JJ	_	16	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	previous	previous	JJ	JJ	_	4	amod	_	_
4	data	datum	NNS	NNS	_	1	nmod	_	_
5	from	from	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	mouse	mouse	NN	NN	_	6	conj	_	_
9	fibroblasts	fibroblast	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	T-lymphocytes	t-lymphocyte	NNS	NNS	_	9	conj	_	_
12	,	,	,	,	_	16	punct	_	_
13	E2F4	e2f4	NN	NN	_	16	nsubj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	DP1	dp1	NN	NN	_	13	conj	_	_
16	form	form	VBP	VBP	_	0	root	_	_
17	the	the	DT	DT	_	20	det	_	_
18	predominant	predominant	JJ	JJ	_	20	amod	_	_
19	E2F	e2f	NN	NN	_	20	compound	_	_
20	heterodimers	heterodimer	NNS	NNS	_	16	dobj	_	_
21	both	both	CC	CC	_	16	nmod	_	_
22	in	in	IN	IN	_	21	case	_	_
23	G0	g0	NN	NN	_	26	compound	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	G1	g1	NN	NN	_	23	conj	_	_
26	phases	phase	NNS	NNS	_	21	dep	_	_
27	of	of	IN	IN	_	32	case	_	_
28	the	the	DT	DT	_	32	det	_	_
29	human	human	JJ	JJ	_	32	amod	_	_
30	B-lymphocyte	b-lymphocyte	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	cycle	cycle	NN	NN	_	26	nmod	_	_
33	,	,	,	,	_	16	punct	_	_
34	whereas	whereas	IN	IN	_	40	mark	_	_
35	E2F1	e2f1	NN	NN	_	40	nsubjpass	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	-3	-3	CD	CD	_	35	conj	_	_
38	are	be	VBP	VBP	_	40	auxpass	_	_
39	first	first	RB	RB	_	40	advmod	_	_
40	detected	detect	VBN	VBN	_	16	advcl	_	_
41	in	in	IN	IN	_	43	case	_	_
42	late	late	JJ	JJ	_	43	amod	_	_
43	G1	g1	NN	NN	_	40	nmod	_	_
44	,	,	,	,	_	16	punct	_	_
45	and	and	CC	CC	_	16	cc	_	_
46	their	they	PRP$	PRP$	_	48	nmod:poss	_	_
47	expression	expression	NN	NN	_	48	compound	_	_
48	levels	level	NNS	NNS	_	49	nsubj	_	_
49	increase	increase	VBP	VBP	_	16	conj	_	_
50	towards	towards	IN	IN	_	52	case	_	_
51	S	s	NN	NN	_	52	compound	_	_
52	phase	phase	NN	NN	_	49	nmod	_	_
53	.	.	.	.	_	16	punct	_	_

1	Intriguingly	intriguingly	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	major	major	JJ	JJ	_	6	amod	_	_
5	E2F	e2f	NN	NN	_	6	compound	_	_
6	complex	complex	NN	NN	_	15	nsubjpass	_	_
7	that	that	WDT	WDT	_	9	dobj	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	detected	detect	VBD	VBD	_	6	acl:relcl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	quiescent	quiescent	JJ	JJ	_	13	amod	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	B-lymphocytes	b-lymphocyte	NNS	NNS	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	consisted	consist	VBN	VBN	_	0	root	_	_
16	of	of	IN	IN	_	17	case	_	_
17	pRB	prb	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	E2F4	e2f4	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	DP1	dp1	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	15	punct	_	_

1	Though	though	IN	IN	_	8	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	levels	level	NNS	NNS	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	DP1	dp1	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	-2	-2	CD	CD	_	5	conj	_	_
8	increase	increase	VBP	VBP	_	23	advcl	_	_
9	when	when	WRB	WRB	_	11	advmod	_	_
10	cells	cell	NNS	NNS	_	11	nsubj	_	_
11	progress	progress	VBP	VBP	_	8	advcl	_	_
12	from	from	IN	IN	_	13	case	_	_
13	G0	g0	NN	NN	_	11	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	S	s	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	23	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	proportion	proportion	NN	NN	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	DP1	dp1	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	DP2	dp2	NN	NN	_	18	nmod	_	_
23	remains	remain	VBZ	VBZ	_	0	root	_	_
24	relatively	relatively	RB	RB	_	25	advmod	_	_
25	constant	constant	JJ	JJ	_	23	xcomp	_	_
26	during	during	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	cycle	cycle	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	increase	increase	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	8	case	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	8	amod	_	_
8	mobility	mobility	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	predominant	predominant	JJ	JJ	_	13	amod	_	_
12	E2F	e2f	NN	NN	_	13	compound	_	_
13	components	component	NNS	NNS	_	8	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	DP1	dp1	NN	NN	_	13	appos	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	E2F4	e2f4	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	as	as	IN	IN	_	21	mark	_	_
20	B-lymphocytes	b-lymphocyte	NNS	NNS	_	21	nsubj	_	_
21	progressed	progress	VBD	VBD	_	3	advcl	_	_
22	from	from	IN	IN	_	23	case	_	_
23	G0	g0	NN	NN	_	21	nmod	_	_
24	into	into	IN	IN	_	26	case	_	_
25	early	early	JJ	JJ	_	26	amod	_	_
26	G1	g1	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	increase	increase	NN	NN	_	6	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	mobility	mobility	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	attributable	attributable	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	dephosphorylation	dephosphorylation	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	as	as	IN	IN	_	15	mark	_	_
11	lambda	lambda	NN	NN	_	13	compound	_	_
12	phosphatase	phosphatase	NN	NN	_	13	compound	_	_
13	treatment	treatment	NN	NN	_	15	nsubj	_	_
14	could	could	MD	MD	_	15	aux	_	_
15	convert	convert	VB	VB	_	6	advcl	_	_
16	the	the	DT	DT	_	19	det	_	_
17	slower	slower	JJR	JJR	_	19	amod	_	_
18	migrating	migrating	JJ	JJ	_	19	amod	_	_
19	forms	form	NNS	NNS	_	15	dobj	_	_
20	into	into	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	corresponding	corresponding	JJ	JJ	_	25	amod	_	_
23	faster	faster	JJR	JJR	_	25	amod	_	_
24	mobility	mobility	NN	NN	_	25	compound	_	_
25	forms	form	NNS	NNS	_	15	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	change	change	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	phosphorylation	phosphorylation	NN	NN	_	9	compound	_	_
9	status	status	NN	NN	_	6	nmod	_	_
10	correlates	correlate	VBZ	VBZ	_	3	ccomp	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	decrease	decrease	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	DNA	dna	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	modulation	modulation	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	mediated	mediate	VBN	VBN	_	2	acl	_	_
8	through	through	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	dephosphorylation	dephosphorylation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	DP1	dp1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	E2F4	e2f4	NN	NN	_	12	conj	_	_
15	could	could	MD	MD	_	16	aux	_	_
16	help	help	VB	VB	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	explain	explain	VB	VB	_	16	xcomp	_	_
19	the	the	DT	DT	_	20	det	_	_
20	lack	lack	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	in	in	FW	FW	_	25	amod	_	_
23	vivo	vivo	FW	FW	_	22	dep	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	footprinting	footprinting	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	late	late	JJ	JJ	_	28	amod	_	_
28	G1	g1	NN	NN	_	20	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	S	s	NN	NN	_	31	compound	_	_
31	phases	phase	NNS	NNS	_	28	conj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	promoters	promoter	NNS	NNS	_	28	nmod	_	_
35	negatively	negatively	RB	RB	_	36	advmod	_	_
36	regulated	regulate	VBN	VBN	_	34	acl	_	_
37	through	through	IN	IN	_	39	case	_	_
38	E2F	e2f	NN	NN	_	39	compound	_	_
39	sites	site	NNS	NNS	_	36	nmod	_	_
40	and	and	CC	CC	_	16	cc	_	_
41	suggests	suggest	VBZ	VBZ	_	16	conj	_	_
42	a	a	DT	DT	_	44	det	_	_
43	novel	novel	JJ	JJ	_	44	amod	_	_
44	mechanism	mechanism	NN	NN	_	41	dobj	_	_
45	for	for	IN	IN	_	46	mark	_	_
46	controlling	control	VBG	VBG	_	44	acl	_	_
47	E2F	e2f	NN	NN	_	49	compound	_	_
48	transcriptional	transcriptional	JJ	JJ	_	49	amod	_	_
49	activity	activity	NN	NN	_	46	dobj	_	_
50	during	during	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	transition	transition	NN	NN	_	46	nmod	_	_
53	from	from	IN	IN	_	54	case	_	_
54	quiescence	quiescence	NN	NN	_	52	nmod	_	_
55	to	to	TO	TO	_	56	case	_	_
56	proliferation	proliferation	NN	NN	_	52	nmod	_	_
57	.	.	.	.	_	16	punct	_	_

1	Retinoid	retinoid	NN	NN	_	3	compound	_	_
2	X	x	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	7	nmod:npmod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	RXR	rxr	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	agonist-induced	agonist-induced	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	18	nsubjpass	_	_
9	of	of	IN	IN	_	15	case	_	_
10	dominant-negative	dominant-negative	JJ	JJ	_	15	amod	_	_
11	RXR-retinoic	rxr-retinoic	JJ	JJ	_	15	amod	_	_
12	acid	acid	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	alpha403	alpha403	NN	NN	_	15	compound	_	_
15	heterodimers	heterodimer	NNS	NNS	_	8	nmod	_	_
16	is	be	VBZ	VBZ	_	18	auxpass	_	_
17	developmentally	developmentally	RB	RB	_	18	advmod	_	_
18	regulated	regulate	VBN	VBN	_	0	root	_	_
19	during	during	IN	IN	_	21	case	_	_
20	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	multiple	multiple	JJ	JJ	_	4	amod	_	_
3	biologic	biologic	JJ	JJ	_	4	amod	_	_
4	activities	activity	NNS	NNS	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	retinoic	retinoic	JJ	JJ	_	7	amod	_	_
7	acid	acid	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RA	ra	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	mediated	mediate	VBN	VBN	_	0	root	_	_
13	through	through	IN	IN	_	23	case	_	_
14	RAR	rar	NN	NN	_	23	compound	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	retinoid	retinoid	NN	NN	_	14	conj	_	_
17	X	x	NN	NN	_	23	compound	_	_
18	receptor	receptor	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	RXR	rxr	NN	NN	_	23	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
23	receptors	receptor	NNS	NNS	_	12	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	interact	interact	VBP	VBP	_	23	acl:relcl	_	_
26	with	with	IN	IN	_	29	case	_	_
27	specific	specific	JJ	JJ	_	29	amod	_	_
28	DNA	dna	NN	NN	_	29	compound	_	_
29	target	target	NN	NN	_	25	nmod	_	_
30	sequences	sequence	VBZ	VBZ	_	29	dep	_	_
31	as	as	IN	IN	_	32	case	_	_
32	heterodimers	heterodimer	NNS	NNS	_	29	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	RXR-RAR	rxr-rar	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	or	or	CC	CC	_	32	cc	_	_
37	homodimers	homodimer	NNS	NNS	_	32	conj	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	RXR-RXR	rxr-rxr	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	12	punct	_	_

1	RA	ra	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	critical	critical	JJ	JJ	_	4	xcomp	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	regulating	regulate	VBG	VBG	_	5	advcl	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	aspects	aspect	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	hematopoiesis	hematopoiesis	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	since	since	IN	IN	_	30	mark	_	_
14	transducing	transduce	VBG	VBG	_	30	csubj	_	_
15	a	a	DT	DT	_	18	det	_	_
16	COOH-terminally	cooh-terminally	RB	RB	_	18	advmod	_	_
17	truncated	truncate	VBN	VBN	_	18	amod	_	_
18	RARalpha	raralpha	NN	NN	_	14	dobj	_	_
19	exhibiting	exhibit	VBG	VBG	_	18	acl	_	_
20	dominant-negative	dominant-negative	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	19	dobj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RARalpha403	raralpha403	NN	NN	_	18	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	into	into	IN	IN	_	29	case	_	_
26	normal	normal	JJ	JJ	_	29	amod	_	_
27	mouse	mouse	NN	NN	_	29	compound	_	_
28	bone	bone	NN	NN	_	29	compound	_	_
29	marrow	marrow	NN	NN	_	14	nmod	_	_
30	generates	generate	VBZ	VBZ	_	4	advcl	_	_
31	hematopoietic	hematopoietic	JJ	JJ	_	35	amod	_	_
32	growth	growth	NN	NN	_	35	compound	_	_
33	factor-dependent	factor-dependent	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	lines	line	NNS	NNS	_	30	dobj	_	_
36	frozen	freeze	VBN	VBN	_	35	acl	_	_
37	at	at	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	multipotent	multipotent	JJ	JJ	_	40	amod	_	_
40	progenitor	progenitor	NN	NN	_	36	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	EML	eml	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	or	or	CC	CC	_	40	cc	_	_
45	committed	commit	VBN	VBN	_	50	amod	_	_
46	promyelocyte	promyelocyte	JJ	JJ	_	50	amod	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	MPRO	mpro	NN	NN	_	50	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	stages	stage	NNS	NNS	_	40	conj	_	_
51	.	.	.	.	_	4	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	relatively	relatively	RB	RB	_	4	advmod	_	_
4	high	high	JJ	JJ	_	7	amod	_	_
5	,	,	,	,	_	4	punct	_	_
6	pharmacological	pharmacological	JJ	JJ	_	4	dep	_	_
7	concentrations	concentration	NNS	NNS	_	19	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	RA	ra	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	17	punct	_	_
11	1	1	CD	CD	_	13	compound	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	10	10	CD	CD	_	17	compound	_	_
14	&amp;	&amp;	CC	CC	_	13	cc	_	_
15	mgr	mgr	NN	NN	_	13	conj	_	_
16	;	;	:	:	_	17	punct	_	_
17	M	m	NN	NN	_	7	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	overcome	overcome	VBP	VBP	_	0	root	_	_
20	these	these	DT	DT	_	22	det	_	_
21	differentiation	differentiation	NN	NN	_	22	compound	_	_
22	blocks	block	NNS	NNS	_	19	dobj	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	induce	induce	VBP	VBP	_	19	conj	_	_
25	terminal	terminal	JJ	JJ	_	27	amod	_	_
26	granulocytic	granulocytic	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	24	dobj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	MPRO	mpro	NN	NN	_	31	compound	_	_
31	promyelocytes	promyelocyte	NNS	NNS	_	27	nmod	_	_
32	while	while	IN	IN	_	33	mark	_	_
33	potentiating	potentiate	VBG	VBG	_	19	advcl	_	_
34	interleukin-3	interleukin-3	NN	NN	_	38	nmod:npmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	IL-3	il-3	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	-induced	-induced	JJ	JJ	_	39	amod	_	_
39	commitment	commitment	NN	NN	_	33	dobj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	EML	eml	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	39	nmod	_	_
43	to	to	TO	TO	_	46	case	_	_
44	the	the	DT	DT	_	46	det	_	_
45	granulocyte/monocyte	granulocyte/monocyte	NN	NN	_	46	compound	_	_
46	lineage	lineage	NN	NN	_	39	nmod	_	_
47	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	utilized	utilize	VBD	VBD	_	0	root	_	_
8	RXR-	rxr-	NN	NN	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	RAR-specific	rar-specific	JJ	JJ	_	8	conj	_	_
11	agonists	agonist	NNS	NNS	_	7	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	antagonists	antagonist	NNS	NNS	_	11	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	determine	determine	VB	VB	_	7	advcl	_	_
16	how	how	WRB	WRB	_	18	advmod	_	_
17	RA	ra	NN	NN	_	18	nsubj	_	_
18	overcomes	overcome	VBZ	VBZ	_	15	ccomp	_	_
19	the	the	DT	DT	_	21	det	_	_
20	dominant-negative	dominant-negative	JJ	JJ	_	21	amod	_	_
21	activity	activity	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	truncated	truncate	VBN	VBN	_	25	amod	_	_
25	RARalpha	raralpha	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	31	case	_	_
27	these	these	DT	DT	_	31	det	_	_
28	different	different	JJ	JJ	_	31	amod	_	_
29	myeloid	myeloid	JJ	JJ	_	31	amod	_	_
30	developmental	developmental	JJ	JJ	_	31	amod	_	_
31	stages	stage	NNS	NNS	_	21	nmod	_	_
32	.	.	.	.	_	7	punct	_	_

1	Unexpectedly	unexpectedly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observed	observe	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	an	a	DT	DT	_	7	det	_	_
7	RXR-specific	rxr-specific	JJ	JJ	_	15	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	rather	rather	RB	RB	_	7	cc	_	_
10	than	than	IN	IN	_	9	mwe	_	_
11	an	a	DT	DT	_	12	det	_	_
12	RAR-specific	rar-specific	JJ	JJ	_	7	conj	_	_
13	,	,	,	,	_	7	punct	_	_
14	agonist	agonist	NN	NN	_	7	dep	_	_
15	induces	induce	VBZ	VBZ	_	4	ccomp	_	_
16	terminal	terminal	JJ	JJ	_	18	amod	_	_
17	granulocytic	granulocytic	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	MPRO	mpro	NN	NN	_	21	compound	_	_
21	promyelocytes	promyelocyte	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	this	this	DT	DT	_	25	det	_	_
25	differentiation	differentiation	NN	NN	_	27	nsubjpass	_	_
26	is	be	VBZ	VBZ	_	27	auxpass	_	_
27	associated	associate	VBN	VBN	_	15	conj	_	_
28	with	with	IN	IN	_	29	case	_	_
29	activation	activation	NN	NN	_	27	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	DNA	dna	NN	NN	_	33	compound	_	_
32	response	response	NN	NN	_	33	compound	_	_
33	elements	element	NNS	NNS	_	29	nmod	_	_
34	corresponding	correspond	VBG	VBG	_	33	acl	_	_
35	to	to	TO	TO	_	37	case	_	_
36	RAR-RXR	rar-rxr	NN	NN	_	37	compound	_	_
37	heterodimers	heterodimer	NNS	NNS	_	34	nmod	_	_
38	rather	rather	RB	RB	_	37	cc	_	_
39	than	than	IN	IN	_	38	mwe	_	_
40	RXR-RXR	rxr-rxr	NN	NN	_	41	compound	_	_
41	homodimers	homodimer	NNS	NNS	_	37	conj	_	_
42	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	RXR	rxr	NN	NN	_	4	compound	_	_
3	agonist	agonist	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	RAR-specific	rar-specific	JJ	JJ	_	9	amod	_	_
9	antagonists	antagonist	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	suggesting	suggest	VBG	VBG	_	6	xcomp	_	_
12	extensive	extensive	JJ	JJ	_	13	amod	_	_
13	cross-talk	cross-talk	NN	NN	_	11	dobj	_	_
14	between	between	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	partners	partner	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	RXR-RARalpha403	rxr-raralpha403	NN	NN	_	20	compound	_	_
20	heterodimer	heterodimer	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	in	in	IN	IN	_	11	case	_	_
5	the	the	DT	DT	_	11	det	_	_
6	more	more	RBR	RBR	_	7	advmod	_	_
7	immature	immature	JJ	JJ	_	11	amod	_	_
8	,	,	,	,	_	7	punct	_	_
9	multipotent	multipotent	JJ	JJ	_	7	dep	_	_
10	EML	eml	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	13	nmod	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	observed	observe	VBD	VBD	_	0	root	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	this	this	DT	DT	_	17	det	_	_
16	RXR-specific	rxr-specific	JJ	JJ	_	17	amod	_	_
17	agonist	agonist	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	inactive	inactive	JJ	JJ	_	13	ccomp	_	_
20	either	either	CC	CC	_	22	cc:preconj	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	potentiating	potentiate	VBG	VBG	_	19	dep	_	_
23	IL-3-mediated	il-3-mediated	JJ	JJ	_	24	amod	_	_
24	commitment	commitment	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	EML	eml	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	to	to	TO	TO	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	granulocyte	granulocyte	NN	NN	_	31	compound	_	_
31	lineage	lineage	NN	NN	_	24	nmod	_	_
32	or	or	CC	CC	_	22	cc	_	_
33	in	in	IN	IN	_	34	mark	_	_
34	transactivating	transactivate	VBG	VBG	_	22	conj	_	_
35	RAR-RXR	rar-rxr	NN	NN	_	37	compound	_	_
36	response	response	NN	NN	_	37	compound	_	_
37	elements	element	NNS	NNS	_	34	dobj	_	_
38	.	.	.	.	_	13	punct	_	_

1	RA-triggered	ra-triggered	JJ	JJ	_	4	amod	_	_
2	GALdbd-RARalpha	galdbd-raralpha	NN	NN	_	4	compound	_	_
3	hybrid	hybrid	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	8	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	indicates	indicate	VBZ	VBZ	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	13	det	_	_
11	multipotent	multipotent	JJ	JJ	_	13	amod	_	_
12	EML	eml	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	14	nsubj	_	_
14	harbor	harbor	VBP	VBP	_	8	ccomp	_	_
15	substantial	substantial	JJ	JJ	_	20	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
17	hormone	hormone	NN	NN	_	20	compound	_	_
18	receptor	receptor	NN	NN	_	20	compound	_	_
19	coactivator	coactivator	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	14	dobj	_	_
21	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	11	det	_	_
4	histone	histone	NN	NN	_	11	compound	_	_
5	deacetylase	deacetylase	NN	NN	_	11	compound	_	_
6	(	(	-LRB-	-LRB-	_	11	punct	_	_
7	HDAC	hdac	NN	NN	_	11	compound	_	_
8	)	)	-RRB-	-RRB-	_	11	punct	_	_
9	inhibitor	inhibitor	NN	NN	_	11	compound	_	_
10	trichostatin	trichostatin	NN	NN	_	11	compound	_	_
11	A	a	NN	NN	_	13	nsubj	_	_
12	readily	readily	RB	RB	_	13	advmod	_	_
13	activates	activate	VBZ	VBZ	_	0	root	_	_
14	an	a	DT	DT	_	17	det	_	_
15	RXR-RAR	rxr-rar	NN	NN	_	17	compound	_	_
16	reporter	reporter	NN	NN	_	17	compound	_	_
17	construct	construct	NN	NN	_	13	dobj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	multipotent	multipotent	JJ	JJ	_	22	amod	_	_
21	EML	eml	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	13	nmod	_	_
23	but	but	CC	CC	_	24	cc	_	_
24	not	not	RB	RB	_	22	cc	_	_
25	in	in	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	committed	commit	VBN	VBN	_	29	amod	_	_
28	MPRO	mpro	NN	NN	_	29	compound	_	_
29	promyelocytes	promyelocyte	NNS	NNS	_	22	conj	_	_
30	,	,	,	,	_	13	punct	_	_
31	indicating	indicate	VBG	VBG	_	13	advcl	_	_
32	that	that	IN	IN	_	48	mark	_	_
33	differences	difference	NNS	NNS	_	48	nsubj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	HDAC-containing	hdac-containing	JJ	JJ	_	37	amod	_	_
36	repressor	repressor	NN	NN	_	37	compound	_	_
37	complexes	complex	NNS	NNS	_	33	nmod	_	_
38	in	in	IN	IN	_	46	case	_	_
39	these	these	DT	DT	_	46	det	_	_
40	two	two	CD	CD	_	46	nummod	_	_
41	closely	closely	RB	RB	_	42	advmod	_	_
42	related	related	JJ	JJ	_	46	amod	_	_
43	but	but	CC	CC	_	42	cc	_	_
44	distinct	distinct	JJ	JJ	_	42	conj	_	_
45	hematopoietic	hematopoietic	JJ	JJ	_	46	amod	_	_
46	lineages	lineage	NNS	NNS	_	37	nmod	_	_
47	might	might	MD	MD	_	48	aux	_	_
48	account	account	VB	VB	_	31	ccomp	_	_
49	for	for	IN	IN	_	52	case	_	_
50	the	the	DT	DT	_	52	det	_	_
51	differential	differential	JJ	JJ	_	52	amod	_	_
52	activation	activation	NN	NN	_	48	nmod	_	_
53	of	of	IN	IN	_	56	case	_	_
54	the	the	DT	DT	_	56	det	_	_
55	RXR-RARalpha403	rxr-raralpha403	NN	NN	_	56	compound	_	_
56	heterodimers	heterodimer	NNS	NNS	_	52	nmod	_	_
57	that	that	WDT	WDT	_	59	dobj	_	_
58	we	we	PRP	PRP	_	59	nsubj	_	_
59	observed	observe	VBD	VBD	_	52	acl:relcl	_	_
60	at	at	IN	IN	_	63	case	_	_
61	these	these	DT	DT	_	63	det	_	_
62	different	different	JJ	JJ	_	63	amod	_	_
63	stages	stage	NNS	NNS	_	59	nmod	_	_
64	of	of	IN	IN	_	66	case	_	_
65	myeloid	myeloid	JJ	JJ	_	66	amod	_	_
66	development	development	NN	NN	_	63	nmod	_	_
67	.	.	.	.	_	13	punct	_	_

1	Bcl-6	bcl-6	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	6	case	_	_
4	reactive	reactive	JJ	JJ	_	6	amod	_	_
5	follicular	follicular	JJ	JJ	_	6	amod	_	_
6	hyperplasia	hyperplasia	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	follicular	follicular	JJ	JJ	_	9	amod	_	_
9	lymphoma	lymphoma	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	angioimmunoblastic	angioimmunoblastic	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	lymphoma	lymphoma	NN	NN	_	6	conj	_	_
15	with	with	IN	IN	_	18	case	_	_
16	hyperplastic	hyperplastic	JJ	JJ	_	18	amod	_	_
17	germinal	germinal	JJ	JJ	_	18	amod	_	_
18	centers	center	NNS	NNS	_	14	nmod	_	_
19	:	:	:	:	_	2	punct	_	_
20	heterogeneity	heterogeneity	NN	NN	_	2	dep	_	_
21	of	of	IN	IN	_	23	case	_	_
22	intrafollicular	intrafollicular	JJ	JJ	_	23	amod	_	_
23	T-cells	t-cell	NNS	NNS	_	20	nmod	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
26	altered	altered	JJ	JJ	_	27	amod	_	_
27	distribution	distribution	NN	NN	_	20	conj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	pathogenesis	pathogenesis	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	angioimmunoblastic	angioimmunoblastic	JJ	JJ	_	34	amod	_	_
33	T-cell	t-cell	NN	NN	_	34	compound	_	_
34	lymphoma	lymphoma	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	6	det	_	_
4	Bcl-6	bcl-6	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	product	product	NN	NN	_	13	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	phosphoprotein	phosphoprotein	NN	NN	_	6	appos	_	_
11	,	,	,	,	_	6	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	expressed	express	VBN	VBN	_	1	appos	_	_
14	independently	independently	RB	RB	_	13	advmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	Bcl-6	bcl-6	NN	NN	_	18	compound	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	rearrangement	rearrangement	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	lymph	lymph	NN	NN	_	3	compound	_	_
3	nodes	node	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	expression	expression	NN	NN	_	10	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Bcl-6	bcl-6	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	10	aux	_	_
10	restricted	restricted	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	17	case	_	_
12	germinal	germinal	JJ	JJ	_	17	amod	_	_
13	center	center	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	GC	gc	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	B-cells	b-cell	NNS	NNS	_	10	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	10	10	CD	CD	_	23	compound	_	_
20	%	%	NN	NN	_	23	dep	_	_
21	to	to	TO	TO	_	23	dep	_	_
22	15	15	CD	CD	_	23	compound	_	_
23	%	%	NN	NN	_	17	conj	_	_
24	of	of	IN	IN	_	28	case	_	_
25	CD3/CD4+	cd3/cd4+	JJ	JJ	_	28	amod	_	_
26	intrafollicular	intrafollicular	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	Interfollicular	interfollicular	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	negative	negative	JJ	JJ	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	Bcl-6	bcl-6	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	except	except	IN	IN	_	14	case	_	_
10	for	for	IN	IN	_	14	case	_	_
11	rare	rare	JJ	JJ	_	14	amod	_	_
12	CD3+/CD4+	cd3+/cd4+	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	4	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	reported	report	VBD	VBD	_	0	root	_	_
5	cases	case	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	angioimmunoblastic	angioimmunoblastic	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	lymphoma	lymphoma	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	AITL	aitl	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	with	with	IN	IN	_	15	case	_	_
14	hyperplastic	hyperplastic	JJ	JJ	_	15	amod	_	_
15	GCs	gc	NNS	NNS	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	AITL/GC	aitl/gc	NN	NN	_	9	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	4	punct	_	_
20	and	and	CC	CC	_	4	cc	_	_
21	observed	observe	VBD	VBD	_	4	conj	_	_
22	that	that	IN	IN	_	29	mark	_	_
23	borders	border	NNS	NNS	_	29	nsubjpass	_	_
24	of	of	IN	IN	_	26	case	_	_
25	enlarged	enlarged	JJ	JJ	_	26	amod	_	_
26	GCs	gc	NNS	NNS	_	23	nmod	_	_
27	were	be	VBD	VBD	_	29	auxpass	_	_
28	ill	ill	RB	RB	_	29	advmod	_	_
29	defined	define	VBN	VBN	_	21	ccomp	_	_
30	,	,	,	,	_	29	punct	_	_
31	with	with	IN	IN	_	32	case	_	_
32	features	feature	NNS	NNS	_	29	nmod	_	_
33	suggestive	suggestive	JJ	JJ	_	32	amod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	an	a	DT	DT	_	37	det	_	_
36	outward	outward	JJ	JJ	_	37	amod	_	_
37	migration	migration	NN	NN	_	33	nmod	_	_
38	of	of	IN	IN	_	40	case	_	_
39	GC	gc	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	37	nmod	_	_
41	to	to	TO	TO	_	44	case	_	_
42	surrounding	surrounding	JJ	JJ	_	44	amod	_	_
43	interfollicular	interfollicular	JJ	JJ	_	44	amod	_	_
44	zones	zone	NNS	NNS	_	37	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	prompted	prompt	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	follicular	follicular	JJ	JJ	_	7	amod	_	_
7	borders	border	NNS	NNS	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	Bcl-6	bcl-6	NN	NN	_	10	compound	_	_
10	staining	staining	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	reactive	reactive	JJ	JJ	_	14	amod	_	_
13	follicular	follicular	JJ	JJ	_	14	amod	_	_
14	hyperplasias	hyperplasias	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	follicular	follicular	JJ	JJ	_	17	amod	_	_
17	lymphomas	lymphoma	NNS	NNS	_	14	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	compare	compare	VB	VB	_	2	xcomp	_	_
20	with	with	IN	IN	_	21	case	_	_
21	AITL/GC	aitl/gc	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Formalin-fixed	formalin-fixed	JJ	JJ	_	7	amod	_	_
6	paraffin	paraffin	NN	NN	_	7	compound	_	_
7	sections	section	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	used	use	VBN	VBN	_	1	dep	_	_
10	for	for	IN	IN	_	11	case	_	_
11	immunostaining	immunostaining	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Bcl-6	bcl-6	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Six	six	CD	CD	_	2	nummod	_	_
2	cases	case	NNS	NNS	_	38	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AITL/GC	aitl/gc	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	12	12	CD	CD	_	10	nummod	_	_
7	nonspecific	nonspecific	JJ	JJ	_	10	amod	_	_
8	reactive	reactive	JJ	JJ	_	10	amod	_	_
9	follicular	follicular	JJ	JJ	_	10	amod	_	_
10	hyperplasia	hyperplasia	NN	NN	_	2	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	FH	fh	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	2	punct	_	_
15	7	7	CD	CD	_	17	nummod	_	_
16	HIV	hiv	NN	NN	_	17	compound	_	_
17	adenopathy	adenopathy	NN	NN	_	2	conj	_	_
18	,	,	,	,	_	2	punct	_	_
19	10	10	CD	CD	_	21	nummod	_	_
20	follicular	follicular	JJ	JJ	_	21	amod	_	_
21	lymphoma	lymphoma	NN	NN	_	2	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	FL	fl	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	2	punct	_	_
26	and	and	CC	CC	_	2	cc	_	_
27	8	8	CD	CD	_	29	nummod	_	_
28	typical	typical	JJ	JJ	_	29	amod	_	_
29	AITL	aitl	NN	NN	_	2	conj	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	ie	ie	FW	FW	_	33	advmod	_	_
32	,	,	,	,	_	33	punct	_	_
33	AITL	aitl	NN	NN	_	29	dep	_	_
34	without	without	IN	IN	_	35	case	_	_
35	GC	gc	NN	NN	_	33	nmod	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	were	be	VBD	VBD	_	38	auxpass	_	_
38	studied	study	VBN	VBN	_	0	root	_	_
39	.	.	.	.	_	38	punct	_	_

1	Double	double	JJ	JJ	_	2	amod	_	_
2	staining	staining	NN	NN	_	11	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	Bcl-6/CD20	bcl-6/cd20	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	Bcl-6/CD3	bcl-6/cd3	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	Bcl-6/CD57	bcl-6/cd57	NN	NN	_	4	conj	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	performed	perform	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	selected	select	VBN	VBN	_	14	amod	_	_
14	cases	case	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	4	case	_	_
4	FH	fh	NN	NN	_	12	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	HIV	hiv	NN	NN	_	7	compound	_	_
7	adenopathy	adenopathy	NN	NN	_	4	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	staining	staining	NN	NN	_	12	nsubj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	Bcl-6	bcl-6	NN	NN	_	9	nmod	_	_
12	revealed	reveal	VBD	VBD	_	1	appos	_	_
13	densely	densely	RB	RB	_	14	advmod	_	_
14	populated	populated	JJ	JJ	_	15	amod	_	_
15	GCs	gc	NNS	NNS	_	12	dobj	_	_
16	with	with	IN	IN	_	21	case	_	_
17	well-defined	well-defined	JJ	JJ	_	21	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	regular	regular	JJ	JJ	_	17	conj	_	_
20	GC	gc	NN	NN	_	21	compound	_	_
21	borders	border	NNS	NNS	_	15	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	whereas	whereas	IN	IN	_	27	mark	_	_
24	Bcl-6+	bcl-6+	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	27	nsubj	_	_
26	were	be	VBD	VBD	_	27	cop	_	_
27	rare	rare	JJ	JJ	_	12	advcl	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	interfollicular	interfollicular	JJ	JJ	_	31	amod	_	_
31	areas	area	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	occasional	occasional	JJ	JJ	_	3	amod	_	_
3	GC	gc	NN	NN	_	10	nsubjpass	_	_
4	with	with	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	ill-defined	ill-defined	JJ	JJ	_	7	amod	_	_
7	border	border	NN	NN	_	3	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	invariably	invariably	RB	RB	_	10	advmod	_	_
10	surrounded	surround	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	broad	broad	JJ	JJ	_	15	amod	_	_
14	mantle	mantle	NN	NN	_	15	compound	_	_
15	zone	zone	NN	NN	_	10	nmod	_	_
16	;	;	:	:	_	10	punct	_	_
17	those	those	DT	DT	_	22	nsubj	_	_
18	with	with	IN	IN	_	21	case	_	_
19	indistinct	indistinct	JJ	JJ	_	21	amod	_	_
20	mantle	mantle	NN	NN	_	21	compound	_	_
21	zones	zone	NNS	NNS	_	17	nmod	_	_
22	had	have	VBD	VBD	_	10	parataxis	_	_
23	well-defined	well-defined	JJ	JJ	_	26	amod	_	_
24	,	,	,	,	_	23	punct	_	_
25	regular	regular	JJ	JJ	_	23	dep	_	_
26	borders	border	NNS	NNS	_	22	dobj	_	_
27	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	FL	fl	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	follicles	follicle	NNS	NNS	_	7	nsubj	_	_
5	were	be	VBD	VBD	_	7	aux	_	_
6	densely	densely	RB	RB	_	7	advmod	_	_
7	populated	populated	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	borders	border	NNS	NNS	_	13	nsubj	_	_
12	were	be	VBD	VBD	_	13	cop	_	_
13	irregular	irregular	JJ	JJ	_	7	conj	_	_
14	,	,	,	,	_	13	punct	_	_
15	with	with	IN	IN	_	18	case	_	_
16	some	some	DT	DT	_	18	det	_	_
17	Bcl-6+	bcl-6+	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	interfollicular	interfollicular	JJ	JJ	_	22	amod	_	_
22	zones	zone	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	AITL/GC	aitl/gc	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	GCs	gc	NNS	NNS	_	7	nsubj	_	_
5	were	be	VBD	VBD	_	7	cop	_	_
6	less	less	RBR	RBR	_	7	advmod	_	_
7	dense	dense	JJ	JJ	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	GC	gc	NN	NN	_	10	compound	_	_
10	borders	border	NNS	NNS	_	13	nsubjpass	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	ill	ill	RB	RB	_	13	advmod	_	_
13	defined	define	VBN	VBN	_	7	ccomp	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	irregular	irregular	JJ	JJ	_	13	conj	_	_
16	,	,	,	,	_	7	punct	_	_
17	and	and	CC	CC	_	7	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	number	number	NN	NN	_	26	nsubjpass	_	_
20	of	of	IN	IN	_	23	case	_	_
21	interfollicular	interfollicular	JJ	JJ	_	23	amod	_	_
22	Bcl-6+	bcl-6+	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	was	be	VBD	VBD	_	26	auxpass	_	_
25	markedly	markedly	RB	RB	_	26	advmod	_	_
26	increased	increase	VBN	VBN	_	7	conj	_	_
27	.	.	.	.	_	7	punct	_	_

1	Double	double	JJ	JJ	_	2	amod	_	_
2	staining	staining	NN	NN	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	these	these	DT	DT	_	8	det	_	_
6	interfollicular	interfollicular	JJ	JJ	_	8	amod	_	_
7	Bcl-6+	bcl-6+	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	14	nsubj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	AITL/GC	aitl/gc	NN	NN	_	8	nmod	_	_
11	were	be	VBD	VBD	_	14	cop	_	_
12	Bcl6+/CD3+/CD20-/CD57-	bcl6+/cd3+/cd20-/cd57-	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	3	ccomp	_	_
15	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	CD3+	cd3+	JJ	JJ	_	6	amod	_	_
4	intrafollicular	intrafollicular	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	depleted	deplete	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	AITL/GC	aitl/gc	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	whereas	whereas	IN	IN	_	15	mark	_	_
13	they	they	PRP	PRP	_	15	nsubj	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	abundant	abundant	JJ	JJ	_	8	advcl	_	_
16	in	in	IN	IN	_	17	case	_	_
17	FH	fh	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Intrafollicular	intrafollicular	JJ	JJ	_	3	amod	_	_
2	CD57+	cd57+	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	stain	stain	VB	VB	_	0	root	_	_
7	for	for	IN	IN	_	8	case	_	_
8	Bcl-6	bcl-6	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	depleted	deplete	VBN	VBN	_	6	conj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	AITL/GC	aitl/gc	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	typical	typical	JJ	JJ	_	3	amod	_	_
3	AITL	aitl	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	some	some	DT	DT	_	7	det	_	_
6	neoplastic	neoplastic	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	positive	positive	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	Bcl-6	bcl-6	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	showing	show	VBG	VBG	_	9	xcomp	_	_
14	variable	variable	JJ	JJ	_	15	amod	_	_
15	degrees	degree	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	staining	staining	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	1	1	LS	LS	_	9	dep	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	GCs	gc	NNS	NNS	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	AITL/GC	aitl/gc	NN	NN	_	6	nmod	_	_
9	differed	differ	VBD	VBD	_	1	appos	_	_
10	from	from	IN	IN	_	11	case	_	_
11	those	those	DT	DT	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	other	other	JJ	JJ	_	16	amod	_	_
14	reactive	reactive	JJ	JJ	_	16	amod	_	_
15	follicular	follicular	JJ	JJ	_	16	amod	_	_
16	hyperplasias	hyperplasias	NN	NN	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	follicular	follicular	JJ	JJ	_	19	amod	_	_
19	lymphomas	lymphoma	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	9	punct	_	_
21	and	and	CC	CC	_	9	cc	_	_
22	staining	stain	VBG	VBG	_	26	nsubj	_	_
23	for	for	IN	IN	_	24	case	_	_
24	Bcl-6	bcl-6	NN	NN	_	22	nmod	_	_
25	was	be	VBD	VBD	_	26	cop	_	_
26	useful	useful	JJ	JJ	_	9	conj	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	discern	discern	VB	VB	_	26	xcomp	_	_
29	them	they	PRP	PRP	_	28	dobj	_	_
30	.	.	.	.	_	1	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	2	2	LS	LS	_	20	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Intrafollicular	intrafollicular	JJ	JJ	_	7	amod	_	_
5	CD3+	cd3+	JJ	JJ	_	7	amod	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	20	nsubjpass	_	_
8	,	,	,	,	_	7	punct	_	_
9	many	many	JJ	JJ	_	14	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	9	nmod	_	_
12	were	be	VBD	VBD	_	14	cop	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	positive	positive	JJ	JJ	_	7	acl:relcl	_	_
15	for	for	IN	IN	_	16	case	_	_
16	Bcl-6	bcl-6	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	7	punct	_	_
18	were	be	VBD	VBD	_	20	auxpass	_	_
19	markedly	markedly	RB	RB	_	20	advmod	_	_
20	depleted	deplete	VBN	VBN	_	0	root	_	_
21	in	in	IN	IN	_	22	case	_	_
22	AITL/GC	aitl/gc	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	20	punct	_	_
24	with	with	IN	IN	_	28	case	_	_
25	increased	increase	VBN	VBN	_	28	amod	_	_
26	interfollicular	interfollicular	JJ	JJ	_	28	amod	_	_
27	Bcl-6+/CD3+	bcl-6+/cd3+	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	20	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	suggesting	suggest	VBG	VBG	_	20	xcomp	_	_
31	an	a	DT	DT	_	33	det	_	_
32	outward	outward	JJ	JJ	_	33	amod	_	_
33	migration	migration	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	intrafollicular	intrafollicular	JJ	JJ	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	33	nmod	_	_
38	in	in	IN	IN	_	40	case	_	_
39	this	this	DT	DT	_	40	det	_	_
40	condition	condition	NN	NN	_	33	nmod	_	_
41	.	.	.	.	_	20	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	3	3	LS	LS	_	11	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Interfollicular	interfollicular	JJ	JJ	_	6	amod	_	_
5	Bcl-6+/CD3+	bcl-6+/cd3+	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	11	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	AITL/GC	aitl/gc	NN	NN	_	6	nmod	_	_
9	were	be	VBD	VBD	_	11	cop	_	_
10	too	too	RB	RB	_	11	advmod	_	_
11	numerous	numerous	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	accounted	account	VBN	VBN	_	11	ccomp	_	_
15	for	for	IN	IN	_	14	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	migration	migration	NN	NN	_	14	nmod	_	_
18	alone	alone	RB	RB	_	17	advmod	_	_
19	,	,	,	,	_	11	punct	_	_
20	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
21	local	local	JJ	JJ	_	22	amod	_	_
22	proliferation	proliferation	NN	NN	_	20	dobj	_	_
23	.	.	.	.	_	11	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	4	4	LS	LS	_	8	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Intrafollicular	intrafollicular	JJ	JJ	_	6	amod	_	_
5	CD57+	cd57+	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	negative	negative	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	10	case	_	_
10	Bcl-6	bcl-6	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	indicating	indicate	VBG	VBG	_	8	xcomp	_	_
13	heterogeneity	heterogeneity	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	intrafollicular	intrafollicular	JJ	JJ	_	18	amod	_	_
17	T-cell	t-cell	NN	NN	_	18	compound	_	_
18	population	population	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	(	(	-LRB-	-LRB-	_	2	punct	_	_
2	5	5	LS	LS	_	9	dep	_	_
3	)	)	-RRB-	-RRB-	_	2	punct	_	_
4	Some	some	DT	DT	_	6	det	_	_
5	neoplastic	neoplastic	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	9	nsubj	_	_
7	in	in	IN	IN	_	8	case	_	_
8	AITL	aitl	NN	NN	_	6	nmod	_	_
9	stained	stain	VBD	VBD	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	Bcl-6	bcl-6	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	9	punct	_	_
13	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
14	up-regulation	up-regulation	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	Bcl-6	bcl-6	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	tumor	tumor	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Angiotensin	angiotensin	NN	NN	_	3	nsubj	_	_
2	II	ii	CD	CD	_	1	nummod	_	_
3	activates	activate	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	9	det	_	_
5	proinflammatory	proinflammatory	JJ	JJ	_	9	amod	_	_
6	transcription	transcription	NN	NN	_	9	compound	_	_
7	factor	factor	NN	NN	_	9	compound	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	factor-kappaB	factor-kappab	NN	NN	_	3	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	9	acl	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	renin-angiotensin	renin-angiotensin	JJ	JJ	_	3	amod	_	_
3	system	system	NN	NN	_	5	nsubj	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	contribute	contribute	VB	VB	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	pathogenesis	pathogenesis	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	atherosclerosis	atherosclerosis	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	common	common	JJ	JJ	_	3	amod	_	_
3	feature	feature	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	all	all	DT	DT	_	6	det	_	_
6	stages	stage	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	atherosclerosis	atherosclerosis	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	inflammation	inflammation	NN	NN	_	0	root	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	vessel	vessel	NN	NN	_	14	compound	_	_
14	wall	wall	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	transcription	transcription	NN	NN	_	5	compound	_	_
3	factor	factor	NN	NN	_	5	compound	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	factor-kappaB	factor-kappab	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	participates	participate	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	13	case	_	_
11	most	most	JJS	JJS	_	13	amod	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	9	nmod	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	inflammation	inflammation	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	examined	examine	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	angiotensin	angiotensin	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	ANG	ang	NN	NN	_	6	nmod	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	II	ii	CD	CD	_	10	nummod	_	_
13	on	on	IN	IN	_	15	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	6	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	23	det	_	_
21	major	major	JJ	JJ	_	23	amod	_	_
22	cellular	cellular	JJ	JJ	_	23	amod	_	_
23	component	component	NN	NN	_	18	appos	_	_
24	of	of	IN	IN	_	26	case	_	_
25	human	human	JJ	JJ	_	26	amod	_	_
26	atheroma	atheroma	NN	NN	_	23	nmod	_	_
27	,	,	,	,	_	4	punct	_	_
28	by	by	IN	IN	_	32	case	_	_
29	electrophoretic	electrophoretic	JJ	JJ	_	32	amod	_	_
30	mobility	mobility	NN	NN	_	32	compound	_	_
31	shift	shift	NN	NN	_	32	compound	_	_
32	assay	assay	NN	NN	_	4	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	ANG	ang	NN	NN	_	7	nsubj	_	_
2	II	ii	CD	CD	_	1	nummod	_	_
3	,	,	,	,	_	7	punct	_	_
4	like	like	IN	IN	_	5	case	_	_
5	TNFalpha	tnfalpha	NN	NN	_	7	nmod	_	_
6	,	,	,	,	_	7	punct	_	_
7	caused	cause	VBD	VBD	_	0	root	_	_
8	rapid	rapid	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	isolated	isolate	VBN	VBN	_	15	acl	_	_
17	from	from	IN	IN	_	19	case	_	_
18	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
19	blood	blood	NN	NN	_	16	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	Ficoll	ficoll	NN	NN	_	23	compound	_	_
22	density	density	NN	NN	_	23	compound	_	_
23	gradient	gradient	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	ANG	ang	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	effect	effect	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	blocked	block	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	13	case	_	_
8	the	the	DT	DT	_	13	det	_	_
9	angiotensin	angiotensin	NN	NN	_	13	compound	_	_
10	AT1	at1	NN	NN	_	13	compound	_	_
11	receptor	receptor	NN	NN	_	13	compound	_	_
12	antagonist	antagonist	NN	NN	_	13	compound	_	_
13	losartan	losartan	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Specificity	specificity	NN	NN	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	6	case	_	_
3	ANG	ang	NN	NN	_	6	compound	_	_
4	II-induced	ii-induced	JJ	JJ	_	6	amod	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	1	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	ascertained	ascertain	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	supershift	supershift	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	competition	competition	NN	NN	_	10	conj	_	_
13	experiments	experiment	NNS	NNS	_	10	dep	_	_
14	.	.	.	.	_	8	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	ANG	ang	NN	NN	_	5	nsubj	_	_
4	II	ii	CD	CD	_	3	nummod	_	_
5	stimulated	stimulate	VBD	VBD	_	0	root	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	10	cc	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	conj	_	_
16	from	from	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	same	same	JJ	JJ	_	19	amod	_	_
19	preparation	preparation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	ability	ability	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	vasoactive	vasoactive	JJ	JJ	_	12	amod	_	_
11	peptide	peptide	NN	NN	_	12	compound	_	_
12	ANG	ang	NN	NN	_	7	nmod	_	_
13	II	ii	CD	CD	_	12	nummod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	activate	activate	VB	VB	_	7	acl	_	_
16	inflammatory	inflammatory	JJ	JJ	_	17	amod	_	_
17	pathways	pathway	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	SHP2-interacting	shp2-interacting	JJ	JJ	_	4	amod	_	_
2	transmembrane	transmembrane	JJ	JJ	_	4	amod	_	_
3	adaptor	adaptor	NN	NN	_	4	compound	_	_
4	protein	protein	NN	NN	_	0	root	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SIT	sit	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	4	punct	_	_
9	a	a	DT	DT	_	12	det	_	_
10	novel	novel	JJ	JJ	_	12	amod	_	_
11	disulfide-linked	disulfide-linked	JJ	JJ	_	12	amod	_	_
12	dimer	dimer	NN	NN	_	4	appos	_	_
13	regulating	regulate	VBG	VBG	_	12	acl	_	_
14	human	human	JJ	JJ	_	17	amod	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	4	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	several	several	JJ	JJ	_	10	amod	_	_
5	low	low	JJ	JJ	_	10	amod	_	_
6	molecular	molecular	JJ	JJ	_	10	amod	_	_
7	weight	weight	NN	NN	_	10	compound	_	_
8	transmembrane	transmembrane	JJ	JJ	_	10	amod	_	_
9	adaptor	adaptor	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	3	dobj	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	recruit	recruit	VBP	VBP	_	10	acl:relcl	_	_
13	src	src	NN	NN	_	21	compound	_	_
14	homology	homology	NN	NN	_	21	compound	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	SH	sh	NN	NN	_	21	compound	_	_
17	)	)	-RRB-	-RRB-	_	21	punct	_	_
18	2	2	CD	CD	_	21	nummod	_	_
19	domain-containing	domain-containing	JJ	JJ	_	21	amod	_	_
20	intracellular	intracellular	JJ	JJ	_	21	amod	_	_
21	molecules	molecule	NNS	NNS	_	12	dobj	_	_
22	to	to	TO	TO	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	membrane	membrane	NN	NN	_	12	nmod	_	_
26	via	via	IN	IN	_	29	case	_	_
27	tyrosine-based	tyrosine-based	JJ	JJ	_	29	amod	_	_
28	signaling	signaling	JJ	JJ	_	29	amod	_	_
29	motifs	motif	NNS	NNS	_	12	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	molecule	molecule	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	group	group	NN	NN	_	6	nmod	_	_
10	termed	term	VBN	VBN	_	9	acl	_	_
11	SIT	sit	NN	NN	_	10	xcomp	_	_
12	(	(	-LRB-	-LRB-	_	17	punct	_	_
13	SHP2	shp2	NN	NN	_	17	compound	_	_
14	interacting	interacting	NN	NN	_	17	compound	_	_
15	transmembrane	transmembrane	JJ	JJ	_	17	amod	_	_
16	adaptor	adaptor	NN	NN	_	17	compound	_	_
17	protein	protein	NN	NN	_	11	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	2	punct	_	_

1	SIT	sit	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	disulfide-linked	disulfide-linked	JJ	JJ	_	6	amod	_	_
5	homodimeric	homodimeric	JJ	JJ	_	6	amod	_	_
6	glycoprotein	glycoprotein	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	6	acl:relcl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	tyrosine	tyrosine	NN	NN	_	3	compound	_	_
3	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
4	by	by	IN	IN	_	5	case	_	_
5	src	src	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	possibly	possibly	RB	RB	_	8	advmod	_	_
8	syk	syk	NN	NN	_	5	conj	_	_
9	protein	protein	NN	NN	_	12	compound	_	_
10	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
11	kinases	kinase	NNS	NNS	_	12	compound	_	_
12	SIT	sit	NN	NN	_	13	nsubj	_	_
13	recruits	recruit	VBZ	VBZ	_	0	root	_	_
14	the	the	DT	DT	_	19	det	_	_
15	SH2	sh2	NN	NN	_	19	compound	_	_
16	domain-containing	domain-containing	JJ	JJ	_	19	amod	_	_
17	tyrosine	tyrosine	NN	NN	_	19	compound	_	_
18	phosphatase	phosphatase	NN	NN	_	19	compound	_	_
19	SHP2	shp2	NN	NN	_	13	dobj	_	_
20	via	via	IN	IN	_	25	case	_	_
21	an	a	DT	DT	_	25	det	_	_
22	immunoreceptor	immunoreceptor	NN	NN	_	25	compound	_	_
23	tyrosine-based	tyrosine-based	JJ	JJ	_	25	amod	_	_
24	inhibition	inhibition	NN	NN	_	25	compound	_	_
25	motif	motif	NN	NN	_	13	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Overexpression	overexpression	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	SIT	sit	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	6	case	_	_
5	Jurkat	jurkat	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	1	nmod	_	_
7	downmodulates	downmodulate	VBZ	VBZ	_	0	root	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	receptor-	receptor-	NN	NN	_	7	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	phytohemagglutinin-mediated	phytohemagglutinin-mediated	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	10	conj	_	_
14	of	of	IN	IN	_	21	case	_	_
15	the	the	DT	DT	_	21	det	_	_
16	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
17	factor	factor	NN	NN	_	21	compound	_	_
18	of	of	IN	IN	_	21	amod	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	10	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NF-AT	nf-at	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	by	by	IN	IN	_	26	mark	_	_
26	interfering	interfere	VBG	VBG	_	7	advcl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	signaling	signaling	NN	NN	_	29	compound	_	_
29	processes	process	NNS	NNS	_	26	nmod	_	_
30	that	that	WDT	WDT	_	33	nsubj	_	_
31	are	be	VBP	VBP	_	33	cop	_	_
32	probably	probably	RB	RB	_	33	advmod	_	_
33	located	located	JJ	JJ	_	29	acl:relcl	_	_
34	upstream	upstream	RB	RB	_	33	advmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	activation	activation	NN	NN	_	34	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	phospholipase	phospholipase	NN	NN	_	39	compound	_	_
39	C	c	NN	NN	_	36	nmod	_	_
40	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	binding	binding	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	SHP2	shp2	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	SIT	sit	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	required	require	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	inhibition	inhibition	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	NF-AT	nf-at	NN	NN	_	15	compound	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	suggesting	suggest	VBG	VBG	_	10	xcomp	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	SIT	sit	NN	NN	_	22	nsubj	_	_
20	not	not	RB	RB	_	21	neg	_	_
21	only	only	RB	RB	_	22	cc:preconj	_	_
22	regulates	regulate	VBZ	VBZ	_	17	ccomp	_	_
23	NF-AT	nf-at	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	22	dobj	_	_
25	but	but	CC	CC	_	22	cc	_	_
26	also	also	RB	RB	_	27	advmod	_	_
27	controls	control	VBZ	VBZ	_	22	conj	_	_
28	NF-AT	nf-at	NN	NN	_	30	compound	_	_
29	unrelated	unrelated	JJ	JJ	_	30	amod	_	_
30	pathways	pathway	NNS	NNS	_	27	dobj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	T	t	NN	NN	_	34	compound	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	activation	activation	NN	NN	_	30	nmod	_	_
35	involving	involve	VBG	VBG	_	36	case	_	_
36	SHP2	shp2	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	GrpL	grpl	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	Grb2-related	grb2-related	JJ	JJ	_	6	amod	_	_
5	adaptor	adaptor	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	8	punct	_	_
8	interacts	interact	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	SLP-76	slp-76	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	regulate	regulate	VB	VB	_	8	xcomp	_	_
13	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
14	factor	factor	NN	NN	_	19	compound	_	_
15	of	of	IN	IN	_	19	amod	_	_
16	activated	activate	VBN	VBN	_	19	amod	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	12	dobj	_	_
20	.	.	.	.	_	8	punct	_	_

1	Propagation	propagation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	signals	signal	NNS	NNS	_	1	nmod	_	_
4	from	from	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	T	t	NN	NN	_	9	compound	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	antigen	antigen	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	TCR	tcr	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	involves	involve	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	number	number	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	adaptor	adaptor	NN	NN	_	18	compound	_	_
18	molecules	molecule	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	SH2	sh2	NN	NN	_	3	compound	_	_
2	domain-containing	domain-containing	JJ	JJ	_	3	amod	_	_
3	protein	protein	NN	NN	_	8	nsubj	_	_
4	76	76	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SLP-76	slp-76	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	interacts	interact	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	15	case	_	_
10	the	the	DT	DT	_	15	det	_	_
11	guanine	guanine	NN	NN	_	15	compound	_	_
12	nucleotide	nucleotide	NN	NN	_	15	compound	_	_
13	exchange	exchange	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	Vav	vav	NN	NN	_	8	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	activate	activate	VB	VB	_	8	xcomp	_	_
18	the	the	DT	DT	_	23	det	_	_
19	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
20	factor	factor	NN	NN	_	23	compound	_	_
21	of	of	IN	IN	_	23	amod	_	_
22	activated	activate	VBN	VBN	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	17	dobj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	NF-AT	nf-at	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	8	punct	_	_
28	and	and	CC	CC	_	8	cc	_	_
29	its	its	PRP$	PRP$	_	30	nmod:poss	_	_
30	expression	expression	NN	NN	_	32	nsubjpass	_	_
31	is	be	VBZ	VBZ	_	32	auxpass	_	_
32	required	require	VBN	VBN	_	8	conj	_	_
33	for	for	IN	IN	_	37	case	_	_
34	normal	normal	JJ	JJ	_	37	amod	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	development	development	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	cloning	cloning	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	characterization	characterization	NN	NN	_	4	conj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	novel	novel	JJ	JJ	_	12	amod	_	_
10	Grb2-like	grb2-like	JJ	JJ	_	12	amod	_	_
11	adaptor	adaptor	NN	NN	_	12	compound	_	_
12	molecule	molecule	NN	NN	_	4	nmod	_	_
13	designated	designate	VBN	VBN	_	12	acl	_	_
14	as	as	IN	IN	_	20	case	_	_
15	Grb2-related	grb2-related	JJ	JJ	_	20	amod	_	_
16	protein	protein	NN	NN	_	20	compound	_	_
17	of	of	IN	IN	_	20	amod	_	_
18	the	the	DT	DT	_	20	det	_	_
19	lymphoid	lymphoid	JJ	JJ	_	20	amod	_	_
20	system	system	NN	NN	_	13	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	GrpL	grpl	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	GrpL	grpl	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	restricted	restrict	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	hematopoietic	hematopoietic	JJ	JJ	_	8	amod	_	_
8	tissues	tissue	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	it	it	PRP	PRP	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	distinguished	distinguish	VBN	VBN	_	5	conj	_	_
14	from	from	IN	IN	_	15	case	_	_
15	Grb2	grb2	NN	NN	_	13	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	having	have	VBG	VBG	_	13	advcl	_	_
18	a	a	DT	DT	_	20	det	_	_
19	proline-rich	proline-rich	JJ	JJ	_	20	amod	_	_
20	region	region	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	5	punct	_	_

1	GrpL	grpl	NN	NN	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	coimmunoprecipitated	coimmunoprecipitate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	SLP-76	slp-76	NN	NN	_	4	nmod	_	_
7	but	but	CC	CC	_	6	cc	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	with	with	IN	IN	_	10	case	_	_
10	Sos1	sos1	NN	NN	_	6	conj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	Sos2	sos2	NN	NN	_	10	conj	_	_
13	from	from	IN	IN	_	16	case	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	lysates	lysate	NNS	NNS	_	4	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	Grb2	grb2	NN	NN	_	7	nsubjpass	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	coimmunoprecipitated	coimmunoprecipitate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	Sos1	sos1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Sos2	sos2	NN	NN	_	9	conj	_	_
12	but	but	CC	CC	_	9	cc	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	with	with	IN	IN	_	15	case	_	_
15	SLP-76	slp-76	NN	NN	_	9	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	Moreover	moreover	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	tyrosine-phosphorylated	tyrosine-phosphorylated	JJ	JJ	_	19	dep	_	_
4	LAT/pp36/38	lat/pp36/38	NN	NN	_	19	dep	_	_
5	in	in	IN	IN	_	19	dep	_	_
6	detergent	detergent	JJ	JJ	_	19	dep	_	_
7	lysates	lysate	NNS	NNS	_	19	dep	_	_
8	prepared	prepare	VBN	VBN	_	19	dep	_	_
9	from	from	IN	IN	_	19	dep	_	_
10	anti-CD3	anti-cd3	NN	NN	_	19	dep	_	_
11	stimulated	stimulate	VBD	VBD	_	19	dep	_	_
12	T	t	NN	NN	_	19	dep	_	_
13	cells	cell	NNS	NNS	_	19	dep	_	_
14	associated	associate	VBN	VBN	_	19	dep	_	_
15	with	with	IN	IN	_	19	dep	_	_
16	Grb2	grb2	NN	NN	_	19	dep	_	_
17	but	but	CC	CC	_	19	cc	_	_
18	not	not	RB	RB	_	19	conj	_	_
19	GrpL	grpl	NN	NN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	presence	presence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	distinct	distinct	JJ	JJ	_	8	amod	_	_
8	complexes	complex	NNS	NNS	_	5	nmod	_	_
9	involving	involve	VBG	VBG	_	10	case	_	_
10	GrpL	grpl	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Grb2	grb2	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	GrpL-SLP-76	grpl-slp-76	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	suggested	suggest	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ability	ability	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	GrpL	grpl	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	act	act	VB	VB	_	12	acl	_	_
17	alone	alone	RB	RB	_	18	advmod	_	_
18	or	or	CC	CC	_	16	advmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	concert	concert	NN	NN	_	18	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	SLP-76	slp-76	NN	NN	_	20	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	augment	augment	VB	VB	_	16	xcomp	_	_
25	NF-AT	nf-at	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	Jurkat	jurkat	NN	NN	_	30	compound	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Unexpected	unexpected	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	coordinated	coordinate	VBN	VBN	_	1	conj	_	_
4	expression	expression	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Spi-1	spi-1	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	Fli-1	fli-1	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	megakaryocytic	megakaryocytic	JJ	JJ	_	12	amod	_	_
12	genes	gene	NNS	NNS	_	6	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	four	four	CD	CD	_	17	nummod	_	_
15	Epo-dependent	epo-dependent	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	4	nmod	_	_
18	established	establish	VBN	VBN	_	17	acl	_	_
19	from	from	IN	IN	_	21	case	_	_
20	transgenic	transgenic	JJ	JJ	_	21	amod	_	_
21	mice	mouse	NNS	NNS	_	18	nmod	_	_
22	displaying	display	VBG	VBG	_	21	acl	_	_
23	erythroid-specific	erythroid-specific	JJ	JJ	_	24	amod	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	30	case	_	_
26	a	a	DT	DT	_	30	det	_	_
27	thermosensitive	thermosensitive	JJ	JJ	_	30	amod	_	_
28	SV40	sv40	NN	NN	_	30	compound	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	antigen	antigen	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Most	most	JJS	JJS	_	4	amod	_	_
2	erythroleukemic	erythroleukemic	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	8	nsubj	_	_
5	established	establish	VBN	VBN	_	4	acl	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	5	advmod	_	_
8	coexpress	coexpress	VBP	VBP	_	0	root	_	_
9	erythrocytic	erythrocytic	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	megakaryocytic	megakaryocytic	JJ	JJ	_	9	conj	_	_
12	markers	marker	NNS	NNS	_	8	dobj	_	_
13	that	that	WDT	WDT	_	16	nsubjpass	_	_
14	often	often	RB	RB	_	16	advmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	12	acl:relcl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	expression	expression	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Spi-1	spi-1	NN	NN	_	18	nmod	_	_
21	and/or	and/or	CC	CC	_	20	cc	_	_
22	Fli-1	fli-1	NN	NN	_	20	conj	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	20	dep	_	_
25	known	know	VBN	VBN	_	20	amod	_	_
26	as	as	IN	IN	_	27	case	_	_
27	transactivators	transactivator	NNS	NNS	_	25	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	megakaryocyte-specific	megakaryocyte-specific	JJ	JJ	_	30	amod	_	_
30	promoters	promoter	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	possibility	possibility	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	establishing	establish	VBG	VBG	_	9	acl	_	_
12	new	new	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	11	dobj	_	_
15	keeping	keep	VBG	VBG	_	14	acl	_	_
16	strictly	strictly	RB	RB	_	15	advmod	_	_
17	erythroid-specific	erythroid-specific	JJ	JJ	_	18	amod	_	_
18	properties	property	NNS	NNS	_	15	dobj	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	11	advmod	_	_
21	through	through	IN	IN	_	26	case	_	_
22	the	the	DT	DT	_	26	det	_	_
23	targeted	target	VBN	VBN	_	26	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	conditional	conditional	JJ	JJ	_	23	conj	_	_
26	immortalization	immortalization	NN	NN	_	11	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	erythrocytic	erythrocytic	JJ	JJ	_	29	amod	_	_
29	progenitors	progenitor	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	7	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	that	that	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	established	establish	VBD	VBD	_	0	root	_	_
7	several	several	JJ	JJ	_	8	amod	_	_
8	lines	line	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	transgenic	transgenic	JJ	JJ	_	11	amod	_	_
11	mice	mouse	NNS	NNS	_	8	nmod	_	_
12	displaying	display	VBG	VBG	_	11	acl	_	_
13	erythroid-specific	erythroid-specific	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	a	a	DT	DT	_	20	det	_	_
17	thermosensitive	thermosensitive	JJ	JJ	_	20	amod	_	_
18	SV40	sv40	NN	NN	_	20	compound	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	antigen	antigen	NN	NN	_	14	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	As	as	IN	IN	_	2	mark	_	_
2	expected	expect	VBN	VBN	_	7	advcl	_	_
3	,	,	,	,	_	7	punct	_	_
4	these	these	DT	DT	_	6	det	_	_
5	transgenic	transgenic	JJ	JJ	_	6	amod	_	_
6	mice	mouse	NNS	NNS	_	7	nsubj	_	_
7	developed	develop	VBD	VBD	_	0	root	_	_
8	splenomegaly	splenomegaly	NN	NN	_	7	dobj	_	_
9	due	due	JJ	JJ	_	13	case	_	_
10	to	to	TO	TO	_	9	mwe	_	_
11	the	the	DT	DT	_	13	det	_	_
12	massive	massive	JJ	JJ	_	13	amod	_	_
13	amplification	amplification	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	20	case	_	_
15	Ter	ter	NN	NN	_	20	compound	_	_
16	119	119	CD	CD	_	20	nummod	_	_
17	positive	positive	JJ	JJ	_	20	amod	_	_
18	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
19	nucleated	nucleated	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	13	nmod	_	_
21	expressing	express	VBG	VBG	_	20	acl	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	antigen	antigen	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	7	punct	_	_

1	Despite	despite	IN	IN	_	4	case	_	_
2	this	this	DT	DT	_	4	det	_	_
3	drastic	drastic	JJ	JJ	_	4	amod	_	_
4	effect	effect	NN	NN	_	17	nmod	_	_
5	in	in	FW	FW	_	4	amod	_	_
6	vivo	vivo	FW	FW	_	5	dep	_	_
7	,	,	,	,	_	17	punct	_	_
8	the	the	DT	DT	_	15	det	_	_
9	in	in	FW	FW	_	15	compound	_	_
10	vitro	vitro	FW	FW	_	15	compound	_	_
11	immortalization	immortalization	NN	NN	_	15	compound	_	_
12	of	of	IN	IN	_	15	amod	_	_
13	erythropoietin-dependent	erythropoietin-dependent	JJ	JJ	_	15	amod	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	17	nsubj	_	_
16	unexpectedly	unexpectedly	RB	RB	_	17	advmod	_	_
17	occurred	occur	VBD	VBD	_	0	root	_	_
18	at	at	IN	IN	_	20	case	_	_
19	low	low	JJ	JJ	_	20	amod	_	_
20	frequency	frequency	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	all	all	DT	DT	_	26	det	_	_
24	four	four	CD	CD	_	26	nummod	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	28	nsubj	_	_
27	established	establish	VBN	VBN	_	26	acl	_	_
28	expressed	express	VBD	VBD	_	17	conj	_	_
29	both	both	CC	CC	_	32	cc:preconj	_	_
30	erythrocytic	erythrocytic	JJ	JJ	_	32	amod	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	globins	globin	NNS	NNS	_	28	dobj	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	and	and	CC	CC	_	32	cc	_	_
35	megakaryocytic	megakaryocytic	JJ	JJ	_	32	conj	_	_
36	markers	marker	NNS	NNS	_	32	dep	_	_
37	(	(	-LRB-	-LRB-	_	39	punct	_	_
38	glycoprotein	glycoprotein	NN	NN	_	39	compound	_	_
39	IIb	iib	NN	NN	_	32	dep	_	_
40	,	,	,	,	_	39	punct	_	_
41	platelet	platelet	NN	NN	_	42	compound	_	_
42	factor	factor	NN	NN	_	39	appos	_	_
43	4	4	CD	CD	_	42	nummod	_	_
44	)	)	-RRB-	-RRB-	_	39	punct	_	_
45	as	as	RB	RB	_	32	cc	_	_
46	well	well	RB	RB	_	45	mwe	_	_
47	as	as	IN	IN	_	45	mwe	_	_
48	Spi-1	spi-1	NN	NN	_	32	conj	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	Fli-1	fli-1	NN	NN	_	48	conj	_	_
51	transcripts	transcript	NNS	NNS	_	48	dep	_	_
52	at	at	IN	IN	_	54	case	_	_
53	permissive	permissive	JJ	JJ	_	54	amod	_	_
54	temperature	temperature	NN	NN	_	28	nmod	_	_
55	.	.	.	.	_	17	punct	_	_

1	Switching	switch	VBG	VBG	_	8	csubj	_	_
2	the	the	DT	DT	_	3	det	_	_
3	cells	cell	NNS	NNS	_	1	dobj	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nonpermissive	nonpermissive	JJ	JJ	_	7	amod	_	_
7	temperature	temperature	NN	NN	_	1	nmod	_	_
8	led	lead	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	marked	marked	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	globin	globin	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	concomitant	concomitant	JJ	JJ	_	19	amod	_	_
19	decrease	decrease	NN	NN	_	12	conj	_	_
20	in	in	IN	IN	_	29	case	_	_
21	expression	expression	NN	NN	_	29	dep	_	_
22	of	of	IN	IN	_	29	case	_	_
23	Spi-1	spi-1	NN	NN	_	29	dep	_	_
24	,	,	,	,	_	29	punct	_	_
25	Fli-1	fli-1	NN	NN	_	29	conj	_	_
26	,	,	,	,	_	29	punct	_	_
27	and	and	CC	CC	_	29	cc	_	_
28	megakaryocytic	megakaryocytic	JJ	JJ	_	29	case	_	_
29	genes	gene	NNS	NNS	_	19	acl	_	_
30	in	in	IN	IN	_	33	case	_	_
31	an	a	DT	DT	_	33	det	_	_
32	erythropoietin-dependent	erythropoietin-dependent	JJ	JJ	_	33	amod	_	_
33	manner	manner	NN	NN	_	8	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	enhanced	enhance	VBN	VBN	_	4	amod	_	_
4	expression	expression	NN	NN	_	12	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Spi-1	spi-1	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Fli-1	fli-1	NN	NN	_	6	conj	_	_
9	genes	gene	NNS	NNS	_	6	dep	_	_
10	already	already	RB	RB	_	12	advmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	Ter	ter	NN	NN	_	19	compound	_	_
16	119	119	CD	CD	_	19	nummod	_	_
17	positive	positive	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	population	population	NN	NN	_	12	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	transgenic	transgenic	JJ	JJ	_	23	amod	_	_
22	mice	mouse	NNS	NNS	_	23	compound	_	_
23	spleen	spleen	NN	NN	_	19	nmod	_	_
24	in	in	FW	FW	_	23	amod	_	_
25	vivo	vivo	FW	FW	_	24	dep	_	_
26	.	.	.	.	_	12	punct	_	_

1	However	however	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	like	like	IN	IN	_	8	case	_	_
4	normal	normal	JJ	JJ	_	8	amod	_	_
5	Ter	ter	NN	NN	_	8	compound	_	_
6	119	119	CD	CD	_	8	nummod	_	_
7	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	19	nmod	_	_
9	,	,	,	,	_	19	punct	_	_
10	these	these	DT	DT	_	14	det	_	_
11	Ter	ter	NN	NN	_	14	compound	_	_
12	119	119	CD	CD	_	14	nummod	_	_
13	positive	positive	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	19	nsubj	_	_
15	from	from	IN	IN	_	17	case	_	_
16	transgenic	transgenic	JJ	JJ	_	17	amod	_	_
17	mice	mouse	NNS	NNS	_	14	nmod	_	_
18	still	still	RB	RB	_	19	advmod	_	_
19	expressed	express	VBD	VBD	_	0	root	_	_
20	high	high	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	beta-globin	beta-globin	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	very	very	RB	RB	_	26	advmod	_	_
26	low	low	JJ	JJ	_	30	amod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	undetectable	undetectable	JJ	JJ	_	26	conj	_	_
29	glycoprotein	glycoprotein	NN	NN	_	30	compound	_	_
30	IIb	iib	NN	NN	_	21	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	platelet	platelet	NN	NN	_	36	compound	_	_
33	factor	factor	NN	NN	_	36	compound	_	_
34	4	4	CD	CD	_	36	nummod	_	_
35	megakaryocytic	megakaryocytic	JJ	JJ	_	36	amod	_	_
36	transcripts	transcript	NNS	NNS	_	30	conj	_	_
37	.	.	.	.	_	19	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	17	mark	_	_
8	the	the	DT	DT	_	10	det	_	_
9	unexpected	unexpected	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	17	nsubj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	megakaryocytic	megakaryocytic	JJ	JJ	_	13	amod	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	17	cop	_	_
15	a	a	DT	DT	_	17	det	_	_
16	specific	specific	JJ	JJ	_	17	amod	_	_
17	property	property	NN	NN	_	6	ccomp	_	_
18	of	of	IN	IN	_	20	case	_	_
19	immortalized	immortalize	VBN	VBN	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	that	that	WDT	WDT	_	25	nsubjpass	_	_
22	can	can	MD	MD	_	25	aux	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	explained	explain	VBN	VBN	_	20	acl:relcl	_	_
26	only	only	RB	RB	_	25	advcl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	enhanced	enhance	VBN	VBN	_	29	amod	_	_
29	expression	expression	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	Spi-1	spi-1	NN	NN	_	29	nmod	_	_
32	and/or	and/or	CC	CC	_	31	cc	_	_
33	Fli-1	fli-1	NN	NN	_	31	conj	_	_
34	genes	gene	NNS	NNS	_	31	dep	_	_
35	.	.	.	.	_	6	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	apoptosis	apoptosis	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	human	human	JJ	JJ	_	10	amod	_	_
7	CD34+	cd34+	JJ	JJ	_	10	amod	_	_
8	hematopoietic	hematopoietic	JJ	JJ	_	10	amod	_	_
9	progenitor	progenitor	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	4	nmod	_	_
11	:	:	:	:	_	3	punct	_	_
12	involvement	involvement	NN	NN	_	21	nsubj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	retinoic	retinoic	JJ	JJ	_	16	amod	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	retinoid	retinoid	NN	NN	_	20	compound	_	_
19	X	x	NN	NN	_	20	compound	_	_
20	receptors	receptor	NNS	NNS	_	16	conj	_	_
21	depends	depend	VBZ	VBZ	_	3	parataxis	_	_
22	on	on	IN	IN	_	24	case	_	_
23	lineage	lineage	NN	NN	_	24	compound	_	_
24	commitment	commitment	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
28	progenitor	progenitor	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Retinoids	retinoid	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	bifunctional	bifunctional	JJ	JJ	_	4	amod	_	_
4	regulators	regulator	NNS	NNS	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	growth	growth	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	differentiation	differentiation	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	explored	explore	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effects	effect	NNS	NNS	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	retinoic	retinoic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RA	ra	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	on	on	IN	IN	_	15	case	_	_
15	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	21	case	_	_
17	human	human	JJ	JJ	_	21	amod	_	_
18	CD34+	cd34+	JJ	JJ	_	21	amod	_	_
19	hematopoietic	hematopoietic	JJ	JJ	_	21	amod	_	_
20	progenitor	progenitor	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	15	nmod	_	_
22	isolated	isolate	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	26	case	_	_
24	normal	normal	JJ	JJ	_	26	amod	_	_
25	bone	bone	NN	NN	_	26	compound	_	_
26	marrow	marrow	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	RA	ra	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	100	100	CD	CD	_	4	nummod	_	_
4	nM	nm	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	an	a	DT	DT	_	8	det	_	_
8	increase	increase	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	percentage	percentage	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	dead	dead	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	24	24	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	8	nmod	_	_
18	to	to	TO	TO	_	20	case	_	_
19	44	44	CD	CD	_	20	nummod	_	_
20	%	%	NN	NN	_	8	nmod	_	_
21	at	at	IN	IN	_	22	case	_	_
22	day	day	NN	NN	_	6	nmod	_	_
23	6	6	CD	CD	_	22	nummod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	p	p	NN	NN	_	26	dep	_	_
26	&lt;	&lt;	JJR	JJR	_	6	parataxis	_	_
27	0.05	0.05	CD	CD	_	26	nummod	_	_
28	,	,	,	,	_	26	punct	_	_
29	n	n	NN	NN	_	30	nsubj	_	_
30	=	=	JJ	JJ	_	26	parataxis	_	_
31	6	6	CD	CD	_	30	dobj	_	_
32	)	)	-RRB-	-RRB-	_	26	punct	_	_
33	as	as	IN	IN	_	34	mark	_	_
34	compared	compare	VBN	VBN	_	6	advcl	_	_
35	to	to	TO	TO	_	37	case	_	_
36	control	control	JJ	JJ	_	37	amod	_	_
37	cells	cell	NNS	NNS	_	34	nmod	_	_
38	cultured	culture	VBN	VBN	_	37	acl	_	_
39	in	in	IN	IN	_	40	case	_	_
40	medium	medium	NN	NN	_	38	nmod	_	_
41	alone	alone	RB	RB	_	40	advmod	_	_
42	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	dose	dose	NN	NN	_	5	nmod:npmod	_	_
5	dependent	dependent	JJ	JJ	_	0	root	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	appeared	appear	VBD	VBD	_	5	conj	_	_
8	relatively	relatively	RB	RB	_	9	advmod	_	_
9	late	late	JJ	JJ	_	7	xcomp	_	_
10	.	.	.	.	_	5	punct	_	_

1	Significant	significant	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	6	case	_	_
6	day	day	NN	NN	_	4	nmod	_	_
7	4	4	CD	CD	_	6	nummod	_	_
8	onward	onward	RB	RB	_	6	advmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	9	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	or	or	CC	CC	_	1	cc	_	_
4	programmed	program	VBN	VBN	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	death	death	NN	NN	_	1	conj	_	_
7	,	,	,	,	_	1	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
10	as	as	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	mode	mode	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	death	death	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	17	mark	_	_
17	using	use	VBG	VBG	_	9	nmod	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TUNEL	tunel	NN	NN	_	20	compound	_	_
20	assay	assay	NN	NN	_	17	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	detects	detect	VBZ	VBZ	_	20	acl:relcl	_	_
24	single	single	JJ	JJ	_	26	amod	_	_
25	strand	strand	NN	NN	_	26	compound	_	_
26	nicks	nick	NNS	NNS	_	23	dobj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	DNA	dna	NN	NN	_	23	nmod	_	_
29	,	,	,	,	_	20	punct	_	_
30	or	or	CC	CC	_	17	cc	_	_
31	by	by	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	Nicoletti	nicoletti	NN	NN	_	34	compound	_	_
34	technique	technique	NN	NN	_	17	conj	_	_
35	demonstrating	demonstrate	VBG	VBG	_	34	acl	_	_
36	a	a	DT	DT	_	38	det	_	_
37	subdiploid	subdiploid	JJ	JJ	_	38	amod	_	_
38	population	population	NN	NN	_	35	dobj	_	_
39	by	by	IN	IN	_	41	case	_	_
40	DNA	dna	NN	NN	_	41	compound	_	_
41	staining	staining	NN	NN	_	35	nmod	_	_
42	.	.	.	.	_	9	punct	_	_

1	RA	ra	NN	NN	_	4	nsubjpass	_	_
2	previously	previously	RB	RB	_	4	advmod	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	inhibit	inhibit	VB	VB	_	4	xcomp	_	_
7	granulocyte	granulocyte	NN	NN	_	9	nmod:npmod	_	_
8	colony-stimulating	colony-stimulating	JJ	JJ	_	9	dep	_	_
9	factor	factor	NN	NN	_	18	amod	_	_
10	--	--	:	:	_	9	punct	_	_
11	and	and	CC	CC	_	12	cc	_	_
12	not	not	RB	RB	_	9	cc	_	_
13	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	17	amod	_	_
14	colony-stimulating	colony-stimulating	JJ	JJ	_	17	amod	_	_
15	factor	factor	NN	NN	_	17	dep	_	_
16	--	--	:	:	_	17	punct	_	_
17	stimulated	stimulate	VBN	VBN	_	9	conj	_	_
18	proliferation	proliferation	NN	NN	_	6	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	CD34+	cd34+	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	RA	ra	NN	NN	_	7	nsubj	_	_
7	opposed	oppose	VBD	VBD	_	4	ccomp	_	_
8	anti-apoptotic	anti-apoptotic	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	G-CSF	g-csf	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	GM-CSF	gm-csf	NN	NN	_	11	conj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	CD34+	cd34+	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	G-CSF	g-csf	NN	NN	_	7	dep	_	_
19	:	:	:	:	_	18	punct	_	_
20	8	8	CD	CD	_	21	nummod	_	_
21	%	%	NN	NN	_	18	dep	_	_
22	dead	dead	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	21	dep	_	_
24	at	at	IN	IN	_	25	case	_	_
25	day	day	NN	NN	_	21	nmod	_	_
26	6	6	CD	CD	_	25	nummod	_	_
27	;	;	:	:	_	18	punct	_	_
28	G-CSF	g-csf	NN	NN	_	18	dep	_	_
29	+	+	CC	CC	_	28	cc	_	_
30	RA	ra	NN	NN	_	28	conj	_	_
31	:	:	:	:	_	28	punct	_	_
32	20	20	CD	CD	_	33	nummod	_	_
33	%	%	NN	NN	_	28	dep	_	_
34	;	;	:	:	_	18	punct	_	_
35	GM-CSF	gm-csf	NN	NN	_	18	dep	_	_
36	:	:	:	:	_	35	punct	_	_
37	12	12	CD	CD	_	38	nummod	_	_
38	%	%	NN	NN	_	35	dep	_	_
39	;	;	:	:	_	18	punct	_	_
40	GM-CSF	gm-csf	NN	NN	_	18	dep	_	_
41	+	+	CC	CC	_	40	cc	_	_
42	RA	ra	NN	NN	_	40	conj	_	_
43	:	:	:	:	_	40	punct	_	_
44	27	27	CD	CD	_	45	nummod	_	_
45	%	%	NN	NN	_	40	dep	_	_
46	)	)	-RRB-	-RRB-	_	18	punct	_	_
47	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	RA	ra	NN	NN	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	apoptosis	apoptosis	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	CD34+	cd34+	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	CD34+CD71+	cd34+cd71+	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	stimulated	stimulate	VBN	VBN	_	8	acl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	erythropoietin	erythropoietin	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	explore	explore	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	6	det	_	_
4	receptor	receptor	NN	NN	_	6	compound	_	_
5	signaling	signaling	NN	NN	_	6	compound	_	_
6	pathways	pathway	NNS	NNS	_	2	dobj	_	_
7	involved	involve	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	RA-induced	ra-induced	JJ	JJ	_	10	amod	_	_
10	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	used	use	VBD	VBD	_	0	root	_	_
14	selective	selective	JJ	JJ	_	15	amod	_	_
15	ligands	ligand	NNS	NNS	_	13	dobj	_	_
16	for	for	IN	IN	_	19	case	_	_
17	retinoic	retinoic	JJ	JJ	_	19	amod	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	RARs	rar	NNS	NNS	_	19	appos	_	_
22	;	;	:	:	_	21	punct	_	_
23	RO13-7410	ro13-7410	NN	NN	_	21	dep	_	_
24	)	)	-RRB-	-RRB-	_	21	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	retinoid	retinoid	NN	NN	_	28	compound	_	_
27	X	x	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	19	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	RXRs	rxr	NNS	NNS	_	28	dep	_	_
31	;	;	:	:	_	30	punct	_	_
32	RO	ro	NN	NN	_	30	dep	_	_
33	25-6603	25-6603	CD	CD	_	32	nummod	_	_
34	)	)	-RRB-	-RRB-	_	30	punct	_	_
35	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	RARs	rar	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	involved	involve	VBN	VBN	_	2	ccomp	_	_
7	in	in	IN	IN	_	9	case	_	_
8	RA-mediated	ra-mediated	JJ	JJ	_	9	amod	_	_
9	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
12	progenitor	progenitor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	whereas	whereas	IN	IN	_	6	dep	_	_
16	RARs	rar	NNS	NNS	_	22	nsubjpass	_	_
17	as	as	RB	RB	_	16	cc	_	_
18	well	well	RB	RB	_	17	mwe	_	_
19	as	as	IN	IN	_	17	mwe	_	_
20	RXRs	rxr	NNS	NNS	_	16	conj	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	involved	involve	VBN	VBN	_	6	parataxis	_	_
23	in	in	IN	IN	_	25	case	_	_
24	RA-mediated	ra-mediated	JJ	JJ	_	25	amod	_	_
25	apoptosis	apoptosis	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	erythroid	erythroid	JJ	JJ	_	29	amod	_	_
28	progenitor	progenitor	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	LPS-Induced	lps-induced	JJ	JJ	_	3	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	14	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	TNF-alpha	tnf-alpha	NN	NN	_	6	compound	_	_
6	release	release	NN	NN	_	3	conj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
10	are	be	VBP	VBP	_	14	cop	_	_
11	protein	protein	NN	NN	_	14	nmod:npmod	_	_
12	tyrosine	tyrosine	NN	NN	_	14	nmod:npmod	_	_
13	kinase	kinase	NN	NN	_	14	nmod:npmod	_	_
14	dependent	dependent	JJ	JJ	_	0	root	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	protein	protein	NN	NN	_	19	nmod:npmod	_	_
17	kinase	kinase	NN	NN	_	19	nmod:npmod	_	_
18	C	c	NN	NN	_	19	nmod:npmod	_	_
19	independent	independent	JJ	JJ	_	14	conj	_	_
20	.	.	.	.	_	14	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Tumor	tumor	NN	NN	_	6	compound	_	_
4	necrosis	necrosis	NN	NN	_	6	compound	_	_
5	factor	factor	NN	NN	_	6	compound	_	_
6	alpha	alpha	NN	NN	_	13	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	an	a	DT	DT	_	13	det	_	_
12	important	important	JJ	JJ	_	13	amod	_	_
13	mediator	mediator	NN	NN	_	1	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	septic	septic	JJ	JJ	_	16	amod	_	_
16	shock	shock	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	Endotoxin	endotoxin	NN	NN	_	6	compound	_	_
2	(	(	-LRB-	-LRB-	_	6	punct	_	_
3	LPS	lps	NN	NN	_	6	compound	_	_
4	)	)	-RRB-	-RRB-	_	6	punct	_	_
5	signal	signal	NN	NN	_	6	compound	_	_
6	transduction	transduction	NN	NN	_	10	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
10	leads	lead	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	factor-kappa	factor-kappa	NN	NN	_	16	compound	_	_
16	B	b	NN	NN	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	TNF-alpha	tnf-alpha	NN	NN	_	22	compound	_	_
22	release	release	NN	NN	_	12	conj	_	_
23	.	.	.	.	_	10	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	implicated	implicate	VBN	VBN	_	0	root	_	_
5	activation	activation	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	both	both	CC	CC	_	10	cc:preconj	_	_
8	protein	protein	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	C	c	NN	NN	_	5	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	PKC	pkc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	protein	protein	NN	NN	_	17	compound	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	kinases	kinase	NNS	NNS	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	PTK	ptk	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	24	case	_	_
22	LPS-induced	lps-induced	JJ	JJ	_	24	amod	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	5	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	hypothesized	hypothesize	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	inhibition	inhibition	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	either	either	CC	CC	_	7	cc:preconj	_	_
7	PKC	pkc	NN	NN	_	4	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	PTK	ptk	NN	NN	_	7	conj	_	_
10	would	would	MD	MD	_	11	aux	_	_
11	decrease	decrease	VB	VB	_	2	ccomp	_	_
12	LPS-induced	lps-induced	JJ	JJ	_	15	amod	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	18	compound	_	_
18	release	release	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	MATERIALS	material	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	Human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	stimulated	stimulate	VBN	VBN	_	1	dep	_	_
9	with	with	IN	IN	_	10	case	_	_
10	PMA	pma	NN	NN	_	8	nmod	_	_
11	(	(	-LRB-	-LRB-	_	13	punct	_	_
12	50	50	CD	CD	_	13	nummod	_	_
13	ng/ml	ng/ml	NN	NN	_	10	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	alone	alone	RB	RB	_	10	advmod	_	_
16	or	or	CC	CC	_	10	cc	_	_
17	LPS	lps	NN	NN	_	10	conj	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	100	100	CD	CD	_	20	nummod	_	_
20	ng/ml	ng/ml	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	with	with	IN	IN	_	30	nmod	_	_
23	and	and	CC	CC	_	30	cc	_	_
24	without	without	IN	IN	_	30	conj	_	_
25	a	a	DT	DT	_	30	det	_	_
26	nonspecific	nonspecific	JJ	JJ	_	30	amod	_	_
27	serine/threonine	serine/threonine	NN	NN	_	30	compound	_	_
28	protein	protein	NN	NN	_	30	compound	_	_
29	kinase	kinase	NN	NN	_	30	compound	_	_
30	inhibitor	inhibitor	NN	NN	_	8	nmod	_	_
31	staurosporine	staurosporine	NN	NN	_	30	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	Stauro	stauro	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	30	punct	_	_
36	a	a	DT	DT	_	40	det	_	_
37	specific	specific	JJ	JJ	_	40	amod	_	_
38	pan-PKC	pan-pkc	NN	NN	_	40	compound	_	_
39	inhibitor	inhibitor	NN	NN	_	40	compound	_	_
40	bisindolylmaleimide	bisindolylmaleimide	NN	NN	_	30	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	Bis	bis	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	30	punct	_	_
45	or	or	CC	CC	_	30	cc	_	_
46	an	a	DT	DT	_	47	det	_	_
47	inhibitor	inhibitor	NN	NN	_	30	conj	_	_
48	of	of	IN	IN	_	49	case	_	_
49	PTK	ptk	NN	NN	_	47	nmod	_	_
50	genistein	genistein	NN	NN	_	47	dep	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	Gen	gen	NN	NN	_	50	appos	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	.	.	.	.	_	1	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	2	compound	_	_
2	release	release	NN	NN	_	7	nsubjpass	_	_
3	in	in	IN	IN	_	5	case	_	_
4	culture	culture	NN	NN	_	5	compound	_	_
5	supernatants	supernatant	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	measured	measure	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	an	a	DT	DT	_	10	det	_	_
10	ELISA	elisa	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
2	DNA	dna	NN	NN	_	3	compound	_	_
3	binding	binding	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	evaluated	evaluate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	electrophoretic	electrophoretic	JJ	JJ	_	10	amod	_	_
8	mobility	mobility	NN	NN	_	10	compound	_	_
9	shift	shift	NN	NN	_	10	compound	_	_
10	assay	assay	NN	NN	_	5	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	LPS	lps	NN	NN	_	4	nsubj	_	_
4	increased	increase	VBD	VBD	_	1	dep	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
6	DNA	dna	NN	NN	_	7	compound	_	_
7	binding	binding	NN	NN	_	4	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	compound	_	_
10	release	release	NN	NN	_	7	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	Nonspecific	nonspecific	JJ	JJ	_	4	amod	_	_
2	protein	protein	NN	NN	_	4	compound	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	inhibition	inhibition	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	10	compound	_	_
10	release	release	NN	NN	_	7	conj	_	_
11	,	,	,	,	_	5	punct	_	_
12	while	while	IN	IN	_	18	mark	_	_
13	specific	specific	JJ	JJ	_	15	amod	_	_
14	PKC	pkc	NN	NN	_	15	compound	_	_
15	inhibition	inhibition	NN	NN	_	18	nsubj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	Bis	bis	NN	NN	_	15	nmod	_	_
18	had	have	VBD	VBD	_	5	advcl	_	_
19	no	no	DT	DT	_	20	neg	_	_
20	effect	effect	NN	NN	_	18	dobj	_	_
21	on	on	IN	IN	_	25	case	_	_
22	LPS-induced	lps-induced	JJ	JJ	_	25	amod	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	25	compound	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	binding	binding	NN	NN	_	18	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	TNF-alpha	tnf-alpha	NN	NN	_	28	compound	_	_
28	release	release	NN	NN	_	25	conj	_	_
29	.	.	.	.	_	5	punct	_	_

1	PTK	ptk	NN	NN	_	2	compound	_	_
2	inhibition	inhibition	NN	NN	_	5	nsubj	_	_
3	with	with	IN	IN	_	4	case	_	_
4	Gen	gen	NN	NN	_	2	nmod	_	_
5	attenuated	attenuate	VBD	VBD	_	0	root	_	_
6	both	both	CC	CC	_	10	cc:preconj	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	10	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	DNA	dna	NN	NN	_	10	compound	_	_
10	binding	binding	NN	NN	_	5	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PKC	pkc	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	PMA	pma	NN	NN	_	2	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	7	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	TNF-alpha	tnf-alpha	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	LPS-induced	lps-induced	JJ	JJ	_	9	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	17	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	12	compound	_	_
12	release	release	NN	NN	_	9	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	independent	independent	JJ	JJ	_	5	ccomp	_	_
18	of	of	IN	IN	_	20	case	_	_
19	PKC	pkc	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	PTK	ptk	NN	NN	_	9	nsubj	_	_
9	plays	play	VBZ	VBZ	_	6	dep	_	_
10	a	a	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	LPS-induced	lps-induced	JJ	JJ	_	15	amod	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	18	compound	_	_
18	release	release	NN	NN	_	15	conj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
22	and	and	CC	CC	_	9	cc	_	_
23	thus	thus	RB	RB	_	29	advmod	_	_
24	could	could	MD	MD	_	29	aux	_	_
25	be	be	VB	VB	_	29	cop	_	_
26	a	a	DT	DT	_	29	det	_	_
27	potential	potential	JJ	JJ	_	29	amod	_	_
28	therapeutic	therapeutic	JJ	JJ	_	29	amod	_	_
29	target	target	NN	NN	_	9	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	inflammatory	inflammatory	JJ	JJ	_	32	amod	_	_
32	states	state	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Dicarba-closo-dodecaboranes	dicarba-closo-dodecaborane	NNS	NNS	_	0	root	_	_
2	as	as	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	pharmacophore	pharmacophore	NN	NN	_	1	nmod	_	_
5	.	.	.	.	_	1	punct	_	_

1	Retinoidal	retinoidal	JJ	JJ	_	2	amod	_	_
2	antagonists	antagonist	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	potential	potential	JJ	JJ	_	5	amod	_	_
5	agonists	agonist	NNS	NNS	_	2	conj	_	_
6	.	.	.	.	_	2	punct	_	_

1	Synthesis	synthesis	NN	NN	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	biological	biological	JJ	JJ	_	1	conj	_	_
4	evaluation	evaluation	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	first	first	JJ	JJ	_	12	amod	_	_
8	dicarba-closo-dodecaborane	dicarba-closo-dodecaborane	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	carborane	carborane	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	derivatives	derivative	NNS	NNS	_	4	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	retinoids	retinoid	NNS	NNS	_	12	nmod	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	described	describe	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Their	they	PRP$	PRP$	_	3	nmod:poss	_	_
2	retinoidal	retinoidal	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	terms	term	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	differentiation-inducing	differentiation-inducing	JJ	JJ	_	11	amod	_	_
11	ability	ability	NN	NN	_	7	nmod	_	_
12	toward	toward	IN	IN	_	17	case	_	_
13	human	human	JJ	JJ	_	17	amod	_	_
14	promyelocytic	promyelocytic	JJ	JJ	_	17	amod	_	_
15	leukemia	leukemia	NN	NN	_	17	compound	_	_
16	HL-60	hl-60	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	High	high	JJ	JJ	_	3	amod	_	_
2	retinoidal	retinoidal	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	15	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	agonist	agonist	NN	NN	_	3	dep	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	antagonist	antagonist	NN	NN	_	5	conj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	retinoic	retinoic	JJ	JJ	_	11	amod	_	_
10	acid	acid	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	RAR	rar	NN	NN	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	5	punct	_	_
15	requires	require	VBZ	VBZ	_	0	root	_	_
16	a	a	DT	DT	_	19	det	_	_
17	carboxylic	carboxylic	JJ	JJ	_	19	amod	_	_
18	acid	acid	NN	NN	_	19	compound	_	_
19	moiety	moiety	NN	NN	_	15	dobj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	an	a	DT	DT	_	24	det	_	_
22	appropriate	appropriate	JJ	JJ	_	24	amod	_	_
23	hydrophobic	hydrophobic	JJ	JJ	_	24	amod	_	_
24	group	group	NN	NN	_	19	conj	_	_
25	located	located	JJ	JJ	_	19	amod	_	_
26	at	at	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	suitable	suitable	JJ	JJ	_	29	amod	_	_
29	position	position	NN	NN	_	25	nmod	_	_
30	on	on	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	molecule	molecule	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	4-carboranyl-substituted	4-carboranyl-substituted	JJ	JJ	_	3	amod	_	_
3	compounds	compound	NNS	NNS	_	9	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	7	7	CD	CD	_	3	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	11	11	CD	CD	_	5	amod	_	_
8	)	)	-RRB-	-RRB-	_	5	punct	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	antagonistic	antagonistic	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	but	but	CC	CC	_	11	cc	_	_
13	no	no	DT	DT	_	15	neg	_	_
14	agonistic	agonistic	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	11	conj	_	_
16	even	even	RB	RB	_	9	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	presence	presence	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	potent	potent	JJ	JJ	_	24	amod	_	_
23	synergist	synergist	NN	NN	_	24	compound	_	_
24	HX630	hx630	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	3-carboranyl-substituted	3-carboranyl-substituted	JJ	JJ	_	8	amod	_	_
8	compounds	compound	NNS	NNS	_	14	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	8	8	CD	CD	_	8	dep	_	_
11	,	,	,	,	_	10	punct	_	_
12	12	12	CD	CD	_	10	amod	_	_
13	)	)	-RRB-	-RRB-	_	10	punct	_	_
14	showed	show	VBD	VBD	_	0	root	_	_
15	potential	potential	JJ	JJ	_	17	amod	_	_
16	agonistic	agonistic	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	14	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	17	cc	_	_
20	no	no	DT	DT	_	22	neg	_	_
21	antagonistic	antagonistic	JJ	JJ	_	22	amod	_	_
22	activity	activity	NN	NN	_	17	conj	_	_
23	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	carboranes	carborane	NNS	NNS	_	7	nsubj	_	_
6	are	be	VBP	VBP	_	7	cop	_	_
7	applicable	applicable	JJ	JJ	_	3	ccomp	_	_
8	as	as	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	hydrophobic	hydrophobic	JJ	JJ	_	11	amod	_	_
11	moiety	moiety	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	biologically	biologically	RB	RB	_	15	advmod	_	_
14	active	active	JJ	JJ	_	15	amod	_	_
15	molecules	molecule	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	dep	_	_
4	immune	immune	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	tumor	tumor	NN	NN	_	8	compound	_	_
8	growth	growth	NN	NN	_	5	conj	_	_
9	by	by	IN	IN	_	11	case	_	_
10	activated	activate	VBN	VBN	_	11	amod	_	_
11	Ras	ras	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	result	result	NN	NN	_	12	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
6	transforming	transform	VBG	VBG	_	7	amod	_	_
7	abilities	ability	NNS	NNS	_	3	nmod	_	_
8	,	,	,	,	_	12	punct	_	_
9	activated	activate	VBN	VBN	_	10	amod	_	_
10	Ras	ras	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	great	great	JJ	JJ	_	16	amod	_	_
16	number	number	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cancers	cancer	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	ras	ras	NN	NN	_	4	compound	_	_
3	mutation	mutation	NN	NN	_	4	compound	_	_
4	frequency	frequency	NN	NN	_	5	nsubj	_	_
5	varies	vary	VBZ	VBZ	_	0	root	_	_
6	between	between	IN	IN	_	8	case	_	_
7	95	95	CD	CD	_	8	nummod	_	_
8	%	%	NN	NN	_	5	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	pancreatic	pancreatic	JJ	JJ	_	11	amod	_	_
11	cancer	cancer	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	5	5	CD	CD	_	14	nummod	_	_
14	%	%	NN	NN	_	8	conj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	breast	breast	NN	NN	_	17	compound	_	_
17	cancer	cancer	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	leukemia	leukemia	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	highest	highest	JJS	JJS	_	6	amod	_	_
6	frequency	frequency	NN	NN	_	12	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	30	30	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	6	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	found	find	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	16	case	_	_
14	acute	acute	JJ	JJ	_	16	amod	_	_
15	myeloid	myeloid	JJ	JJ	_	16	amod	_	_
16	leukemia	leukemia	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	ras	ras	NN	NN	_	5	compound	_	_
5	mutations	mutation	NNS	NNS	_	2	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	correlated	correlate	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	poor	poor	JJ	JJ	_	12	amod	_	_
12	prognosis	prognosis	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	negative	negative	JJ	JJ	_	16	amod	_	_
15	clinical	clinical	JJ	JJ	_	16	amod	_	_
16	outcome	outcome	NN	NN	_	12	conj	_	_
17	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	mutated	mutate	VBN	VBN	_	5	amod	_	_
5	Ras	ras	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	2	ccomp	_	_
7	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	favor	favor	VBP	VBP	_	7	acl:relcl	_	_
11	tumor	tumor	NN	NN	_	12	compound	_	_
12	growth	growth	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	10	punct	_	_
14	enhance	enhance	VBP	VBP	_	10	conj	_	_
15	the	the	DT	DT	_	17	det	_	_
16	metastatic	metastatic	JJ	JJ	_	17	amod	_	_
17	capacity	capacity	NN	NN	_	14	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	tumors	tumor	NNS	NNS	_	17	nmod	_	_
20	or	or	CC	CC	_	10	cc	_	_
21	modulate	modulate	VBP	VBP	_	10	conj	_	_
22	tumor-specific	tumor-specific	JJ	JJ	_	24	amod	_	_
23	immune	immune	JJ	JJ	_	24	amod	_	_
24	responses	response	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Several	several	JJ	JJ	_	3	amod	_	_
2	new	new	JJ	JJ	_	3	amod	_	_
3	functions	function	NNS	NNS	_	28	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Ras	ras	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	such	such	JJ	JJ	_	9	case	_	_
8	as	as	IN	IN	_	7	mwe	_	_
9	downregulation	downregulation	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	major	major	JJ	JJ	_	14	amod	_	_
12	histocompatibility	histocompatibility	NN	NN	_	14	compound	_	_
13	complex	complex	NN	NN	_	14	compound	_	_
14	molecules	molecule	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	upregulation	upregulation	NN	NN	_	9	appos	_	_
17	of	of	IN	IN	_	19	case	_	_
18	certain	certain	JJ	JJ	_	19	amod	_	_
19	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	growth	growth	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	19	conj	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	degradative	degradative	JJ	JJ	_	25	amod	_	_
25	enzymes	enzyme	NNS	NNS	_	19	conj	_	_
26	have	have	VBP	VBP	_	28	aux	_	_
27	been	be	VBN	VBN	_	28	aux	_	_
28	uncovered	uncovered	JJ	JJ	_	0	root	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	last	last	JJ	JJ	_	32	amod	_	_
32	decade	decade	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	28	punct	_	_

1	Additionally	additionally	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	mutated	mutate	VBN	VBN	_	4	amod	_	_
4	Ras	ras	NN	NN	_	7	nsubj	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	serve	serve	VB	VB	_	0	root	_	_
8	as	as	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	primary	primary	JJ	JJ	_	11	amod	_	_
11	target	target	NN	NN	_	7	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	development	development	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	immunotherapy	immunotherapy	NN	NN	_	14	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	drug	drug	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	4	nsubj	_	_
3	will	will	MD	MD	_	4	aux	_	_
4	discuss	discuss	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	which	which	WDT	WDT	_	13	nmod	_	_
9	Ras	ras	NN	NN	_	13	nsubj	_	_
10	expressing	expressing	NN	NN	_	9	dep	_	_
11	tumors	tumor	NNS	NNS	_	10	dobj	_	_
12	are	be	VBP	VBP	_	13	cop	_	_
13	able	able	JJ	JJ	_	6	acl:relcl	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	evade	evade	VB	VB	_	13	xcomp	_	_
16	destruction	destruction	NN	NN	_	15	dobj	_	_
17	by	by	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	immune	immune	JJ	JJ	_	20	amod	_	_
20	system	system	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	enhance	enhance	VBP	VBP	_	15	conj	_	_
23	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
24	growth	growth	NN	NN	_	22	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	metastatic	metastatic	JJ	JJ	_	27	amod	_	_
27	potential	potential	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	4	nsubj	_	_
2	will	will	MD	MD	_	4	aux	_	_
3	further	further	RB	RB	_	4	advmod	_	_
4	elaborate	elaborate	VB	VB	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	attempts	attempt	NNS	NNS	_	4	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	develop	develop	VB	VB	_	7	acl	_	_
10	successful	successful	JJ	JJ	_	11	amod	_	_
11	immunotherapy	immunotherapy	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	drug	drug	NN	NN	_	14	compound	_	_
14	therapy	therapy	NN	NN	_	11	conj	_	_
15	targeting	target	VBG	VBG	_	14	acl	_	_
16	Ras	ras	NN	NN	_	15	dobj	_	_
17	expressing	expressing	NN	NN	_	16	dep	_	_
18	tumors	tumor	NNS	NNS	_	17	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	E2A-HLF	e2a-hlf	NN	NN	_	5	compound	_	_
4	chimeric	chimeric	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	induced	induce	VBD	VBD	_	0	root	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	apoptosis	apoptosis	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	B-cell	b-cell	NN	NN	_	12	compound	_	_
11	maturation	maturation	NN	NN	_	12	compound	_	_
12	arrest	arrest	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	development	development	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	acute	acute	JJ	JJ	_	19	amod	_	_
18	lymphoblastic	lymphoblastic	JJ	JJ	_	19	amod	_	_
19	leukemia	leukemia	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	E2A-HLF	e2a-hlf	NN	NN	_	4	compound	_	_
3	fusion	fusion	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	17	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	generated	generate	VBN	VBN	_	4	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	t(17;19)(q22;p13)	t(17;19)(q22;p13)	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	acute	acute	JJ	JJ	_	12	amod	_	_
11	lymphoblastic	lymphoblastic	JJ	JJ	_	12	amod	_	_
12	leukemia	leukemia	NN	NN	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	ALL	all	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	17	punct	_	_
17	encodes	encode	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	21	det	_	_
19	chimeric	chimeric	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factor	factor	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	30	nmod	_	_
24	the	the	DT	DT	_	26	det	_	_
25	trans-activating	trans-activating	JJ	JJ	_	26	amod	_	_
26	domains	domain	NNS	NNS	_	30	nsubjpass	_	_
27	of	of	IN	IN	_	28	case	_	_
28	E2A	e2a	NN	NN	_	26	nmod	_	_
29	are	be	VBP	VBP	_	30	auxpass	_	_
30	fused	fuse	VBN	VBN	_	21	acl:relcl	_	_
31	to	to	TO	TO	_	36	case	_	_
32	the	the	DT	DT	_	36	det	_	_
33	DNA-binding	dna-binding	JJ	JJ	_	36	compound	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	dimerization	dimerization	NN	NN	_	33	conj	_	_
36	domains	domain	NNS	NNS	_	30	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	hepatic	hepatic	JJ	JJ	_	40	amod	_	_
39	leukemic	leukemic	JJ	JJ	_	40	amod	_	_
40	factor	factor	NN	NN	_	36	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	HLF	hlf	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	.	.	.	.	_	17	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	8	advcl	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	biological	biological	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	generated	generate	VBD	VBD	_	0	root	_	_
9	transgenic	transgenic	JJ	JJ	_	10	amod	_	_
10	mice	mouse	NNS	NNS	_	8	dobj	_	_
11	expressing	express	VBG	VBG	_	10	acl	_	_
12	E2A-HLF	e2a-hlf	NN	NN	_	11	dobj	_	_
13	using	use	VBG	VBG	_	11	advcl	_	_
14	Ig	ig	NN	NN	_	13	dobj	_	_
15	enhancer	enhancer	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	promoter	promoter	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	14	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	direct	direct	VBP	VBP	_	14	acl:relcl	_	_
21	transgene	transgene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	cells	cell	NNS	NNS	_	20	nmod	_	_
25	committed	commit	VBN	VBN	_	24	amod	_	_
26	to	to	TO	TO	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	lymphoid	lymphoid	JJ	JJ	_	29	amod	_	_
29	lineage	lineage	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transgenic	transgenic	JJ	JJ	_	3	amod	_	_
3	mice	mouse	NNS	NNS	_	4	nsubj	_	_
4	exhibited	exhibit	VBD	VBD	_	0	root	_	_
5	abnormal	abnormal	JJ	JJ	_	6	amod	_	_
6	development	development	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	thymus	thymus	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	spleen	spleen	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	were	be	VBD	VBD	_	14	cop	_	_
14	susceptible	susceptible	JJ	JJ	_	4	conj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	infection	infection	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	thymus	thymus	NN	NN	_	3	nsubj	_	_
3	contained	contain	VBD	VBD	_	0	root	_	_
4	small	small	JJ	JJ	_	5	amod	_	_
5	numbers	number	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	thymocytes	thymocyte	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	TUNEL	tunel	NN	NN	_	11	compound	_	_
11	staining	staining	NN	NN	_	12	nsubj	_	_
12	showed	show	VBD	VBD	_	3	conj	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	higher	higher	JJR	JJR	_	15	amod	_	_
15	population	population	NN	NN	_	19	nsubj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	thymocytes	thymocyte	NNS	NNS	_	15	nmod	_	_
18	were	be	VBD	VBD	_	19	aux	_	_
19	undergoing	undergo	VBG	VBG	_	12	ccomp	_	_
20	apoptosis	apoptosis	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	spleen	spleen	NN	NN	_	3	nsubj	_	_
3	exhibited	exhibit	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	reduction	reduction	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	splenic	splenic	JJ	JJ	_	9	amod	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	3	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	the	the	DT	DT	_	14	det	_	_
12	flow	flow	NN	NN	_	14	compound	_	_
13	cytometric	cytometric	JJ	JJ	_	14	amod	_	_
14	analyses	analysis	NNS	NNS	_	22	nsubj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	the	the	DT	DT	_	21	det	_	_
17	in	in	FW	FW	_	21	compound	_	_
18	vitro	vitro	FW	FW	_	21	compound	_	_
19	colony	colony	NN	NN	_	21	compound	_	_
20	formation	formation	NN	NN	_	21	compound	_	_
21	assays	assay	NNS	NNS	_	14	conj	_	_
22	showed	show	VBD	VBD	_	3	conj	_	_
23	that	that	IN	IN	_	28	mark	_	_
24	the	the	DT	DT	_	26	det	_	_
25	B-cell	b-cell	NN	NN	_	26	compound	_	_
26	maturation	maturation	NN	NN	_	28	nsubjpass	_	_
27	was	be	VBD	VBD	_	28	auxpass	_	_
28	blocked	block	VBN	VBN	_	22	ccomp	_	_
29	at	at	IN	IN	_	34	case	_	_
30	a	a	DT	DT	_	34	det	_	_
31	very	very	RB	RB	_	34	advmod	_	_
32	early	early	JJ	JJ	_	34	amod	_	_
33	developmental	developmental	JJ	JJ	_	34	amod	_	_
34	stage	stage	NN	NN	_	28	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicated	indicate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	E2A-HLF	e2a-hlf	NN	NN	_	6	nmod	_	_
9	induced	induce	VBD	VBD	_	3	ccomp	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	B-cell	b-cell	NN	NN	_	15	compound	_	_
14	maturation	maturation	NN	NN	_	15	compound	_	_
15	arrest	arrest	NN	NN	_	11	conj	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vivo	vivo	FW	FW	_	9	advmod	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	that	that	IN	IN	_	31	mark	_	_
20	the	the	DT	DT	_	21	det	_	_
21	susceptibility	susceptibility	NN	NN	_	31	nsubj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transgenic	transgenic	JJ	JJ	_	25	amod	_	_
25	mice	mouse	NNS	NNS	_	21	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	infection	infection	NN	NN	_	21	nmod	_	_
28	was	be	VBD	VBD	_	31	cop	_	_
29	due	due	JJ	JJ	_	31	case	_	_
30	to	to	TO	TO	_	29	mwe	_	_
31	immunodeficiency	immunodeficiency	NN	NN	_	9	conj	_	_
32	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	several	several	JJ	JJ	_	5	amod	_	_
4	transgenic	transgenic	JJ	JJ	_	5	amod	_	_
5	mice	mouse	NNS	NNS	_	6	nsubj	_	_
6	developed	develop	VBD	VBD	_	0	root	_	_
7	acute	acute	JJ	JJ	_	8	amod	_	_
8	leukemia	leukemia	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	classified	classify	VBN	VBN	_	8	acl	_	_
11	as	as	IN	IN	_	12	case	_	_
12	T-ALL	t-all	NN	NN	_	10	nmod	_	_
13	based	base	VBN	VBN	_	18	case	_	_
14	on	on	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	dep	_	_
16	surface	surface	NN	NN	_	18	compound	_	_
17	marker	marker	NN	NN	_	18	compound	_	_
18	analysis	analysis	NN	NN	_	10	advcl	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	DNA	dna	NN	NN	_	21	compound	_	_
21	rearrangements	rearrangement	NNS	NNS	_	18	conj	_	_
22	,	,	,	,	_	6	punct	_	_
23	suggesting	suggest	VBG	VBG	_	6	advcl	_	_
24	that	that	IN	IN	_	29	mark	_	_
25	an	a	DT	DT	_	27	det	_	_
26	additional	additional	JJ	JJ	_	27	amod	_	_
27	event	event	NN	NN	_	29	nsubjpass	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	required	require	VBN	VBN	_	23	ccomp	_	_
30	for	for	IN	IN	_	32	case	_	_
31	malignant	malignant	JJ	JJ	_	32	amod	_	_
32	transformation	transformation	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	lymphoid	lymphoid	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	expressing	express	VBG	VBG	_	35	acl	_	_
37	E2A-HLF	e2a-hlf	NN	NN	_	36	dobj	_	_
38	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	insight	insight	NN	NN	_	3	dobj	_	_
5	into	into	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	biological	biological	JJ	JJ	_	8	amod	_	_
8	function	function	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	E2A-HLF	e2a-hlf	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
13	development	development	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	also	also	RB	RB	_	17	advmod	_	_
16	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
17	role	role	NN	NN	_	4	conj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	leukemogenesis	leukemogenesis	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	disposition	disposition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	sulphamethoxazole	sulphamethoxazole	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
7	metabolites	metabolite	NNS	NNS	_	2	conj	_	_
8	:	:	:	:	_	2	punct	_	_
9	implications	implication	NNS	NNS	_	11	compound	_	_
10	for	for	IN	IN	_	11	amod	_	_
11	hypersensitivity	hypersensitivity	NN	NN	_	2	dep	_	_
12	.	.	.	.	_	2	punct	_	_

1	1.	1.	LS	LS	_	16	dep	_	_
2	Bioactivation	bioactivation	NN	NN	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	sulphamethoxazole	sulphamethoxazole	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	SMX	smx	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	to	to	TO	TO	_	10	case	_	_
9	chemically-reactive	chemically-reactive	JJ	JJ	_	10	amod	_	_
10	metabolites	metabolite	NNS	NNS	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	subsequent	subsequent	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	conjugation	conjugation	NN	NN	_	10	conj	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	thought	think	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	19	mark	_	_
18	be	be	VB	VB	_	19	auxpass	_	_
19	involved	involve	VBN	VBN	_	16	xcomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	SMX	smx	NN	NN	_	22	compound	_	_
22	hypersensitivity	hypersensitivity	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	dep	_	_
6	cellular	cellular	JJ	JJ	_	7	amod	_	_
7	metabolism	metabolism	NN	NN	_	4	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	disposition	disposition	NN	NN	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	conjugation	conjugation	NN	NN	_	7	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	SMX	smx	NN	NN	_	7	nmod	_	_
14	and	and	CC	CC	_	7	cc	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	metabolites	metabolite	NNS	NNS	_	7	conj	_	_
17	in	in	FW	FW	_	16	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	2.	2.	FW	FW	_	4	dep	_	_
2	Flow	flow	NN	NN	_	3	compound	_	_
3	cytometry	cytometry	NN	NN	_	4	nsubj	_	_
4	revealed	reveal	VBD	VBD	_	0	root	_	_
5	binding	binding	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	16	case	_	_
7	N-hydroxy	n-hydroxy	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	SMX-NHOH	smx-nhoh	NN	NN	_	16	compound	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	nitroso	nitroso	NN	NN	_	14	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SMX-NO	smx-no	NN	NN	_	9	conj	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	metabolites	metabolite	NNS	NNS	_	5	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	SMX	smx	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	16	punct	_	_
20	but	but	CC	CC	_	16	cc	_	_
21	not	not	RB	RB	_	23	neg	_	_
22	of	of	IN	IN	_	23	case	_	_
23	SMX	smx	NN	NN	_	16	conj	_	_
24	itself	itself	PRP	PRP	_	23	nmod:npmod	_	_
25	,	,	,	,	_	16	punct	_	_
26	to	to	TO	TO	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	surface	surface	NN	NN	_	5	nmod	_	_
29	of	of	IN	IN	_	33	case	_	_
30	viable	viable	JJ	JJ	_	33	case	_	_
31	white	white	JJ	JJ	_	33	amod	_	_
32	blood	blood	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	haptenation	haptenation	NN	NN	_	6	nsubjpass	_	_
3	by	by	IN	IN	_	4	case	_	_
4	SMX-NO	smx-no	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	reduced	reduce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	exogenous	exogenous	JJ	JJ	_	9	amod	_	_
9	glutathione	glutathione	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	GSH	gsh	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	.	.	.	.	_	6	punct	_	_

1	3.	3.	LS	LS	_	7	dep	_	_
2	SMX-NHOH	smx-nhoh	NN	NN	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	SMX-NO	smx-no	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	rapidly	rapidly	RB	RB	_	7	advmod	_	_
7	reduced	reduce	VBN	VBN	_	0	root	_	_
8	back	back	RB	RB	_	7	advcl	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	parent	parent	JJ	JJ	_	12	amod	_	_
12	compound	compound	NN	NN	_	8	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	cysteine	cysteine	NN	NN	_	7	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	CYS	cys	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	GSH	gsh	NN	NN	_	14	conj	_	_
20	,	,	,	,	_	14	punct	_	_
21	human	human	JJ	JJ	_	24	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
23	blood	blood	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	14	conj	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	plasma	plasma	NN	NN	_	14	conj	_	_
27	,	,	,	,	_	7	punct	_	_
28	suggesting	suggest	VBG	VBG	_	7	advcl	_	_
29	that	that	IN	IN	_	37	mark	_	_
30	this	this	DT	DT	_	37	nsubj	_	_
31	is	be	VBZ	VBZ	_	37	cop	_	_
32	an	a	DT	DT	_	37	det	_	_
33	important	important	JJ	JJ	_	37	amod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	ubiquitous	ubiquitous	JJ	JJ	_	33	conj	_	_
36	bioinactivation	bioinactivation	NN	NN	_	37	compound	_	_
37	mechanism	mechanism	NN	NN	_	28	ccomp	_	_
38	.	.	.	.	_	7	punct	_	_

1	4.	4.	LS	LS	_	4	dep	_	_
2	Fluorescence	fluorescence	NN	NN	_	3	compound	_	_
3	HPLC	hplc	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	SMX-NHOH	smx-nhoh	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	SMX-NO	smx-no	NN	NN	_	6	conj	_	_
9	depleted	deplete	VBD	VBD	_	4	ccomp	_	_
10	CYS	cys	NN	NN	_	9	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	GSH	gsh	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	buffer	buffer	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	9	punct	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	to	to	TO	TO	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	lesser	lesser	JJR	JJR	_	20	amod	_	_
20	extent	extent	NN	NN	_	9	conj	_	_
21	,	,	,	,	_	9	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	cells	cell	NNS	NNS	_	9	conj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	plasma	plasma	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	5.	5.	LS	LS	_	10	dep	_	_
2	Neutrophil	neutrophil	NN	NN	_	3	compound	_	_
3	apoptosis	apoptosis	NN	NN	_	10	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	inhibition	inhibition	NN	NN	_	3	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	function	function	NN	NN	_	5	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	at	at	IN	IN	_	13	case	_	_
12	lower	lower	JJR	JJR	_	13	amod	_	_
13	concentrations	concentration	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	SMX-NHOH	smx-nhoh	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	SMX-NO	smx-no	NN	NN	_	15	conj	_	_
18	than	than	IN	IN	_	19	case	_	_
19	those	those	DT	DT	_	13	nmod	_	_
20	inducing	induce	VBG	VBG	_	19	acl	_	_
21	loss	loss	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	membrane	membrane	NN	NN	_	24	compound	_	_
24	viability	viability	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	10	punct	_	_
26	with	with	IN	IN	_	28	mark	_	_
27	SMX	smx	NN	NN	_	28	nsubj	_	_
28	having	have	VBG	VBG	_	10	advcl	_	_
29	no	no	DT	DT	_	30	neg	_	_
30	effect	effect	NN	NN	_	28	dobj	_	_
31	.	.	.	.	_	10	punct	_	_

1	Lymphocytes	lymphocyte	NNS	NNS	_	10	nsubj	_	_
2	were	be	VBD	VBD	_	10	cop	_	_
3	significantly	significantly	RB	RB	_	10	advmod	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	P	p	NN	NN	_	7	nsubj	_	_
6	&lt;	&lt;	JJR	JJR	_	7	dep	_	_
7	0.05	0.05	CD	CD	_	3	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	more	more	RBR	RBR	_	10	advmod	_	_
10	sensitive	sensitive	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	direct	direct	JJ	JJ	_	15	amod	_	_
14	cytotoxic	cytotoxic	JJ	JJ	_	15	amod	_	_
15	effects	effect	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	SMX-NO	smx-no	NN	NN	_	15	nmod	_	_
18	than	than	IN	IN	_	19	case	_	_
19	neutrophils	neutrophil	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	6.	6.	LS	LS	_	16	dep	_	_
2	Partitioning	partitioning	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SMX-NHOH	smx-nhoh	NN	NN	_	2	nmod	_	_
5	into	into	IN	IN	_	8	case	_	_
6	red	red	JJ	JJ	_	8	amod	_	_
7	blood	blood	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	was	be	VBD	VBD	_	16	cop	_	_
10	significantly	significantly	RB	RB	_	16	advmod	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	P	p	NN	NN	_	14	nsubj	_	_
13	&lt;	&lt;	JJR	JJR	_	14	dep	_	_
14	0.05	0.05	CD	CD	_	10	dep	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	lower	lower	JJR	JJR	_	0	root	_	_
17	than	than	IN	IN	_	20	case	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	hydroxylamine	hydroxylamine	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	dapsone	dapsone	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	16	punct	_	_

1	7.	7.	LS	LS	_	4	dep	_	_
2	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	balance	balance	NN	NN	_	24	nsubj	_	_
8	between	between	IN	IN	_	9	case	_	_
9	oxidation	oxidation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	SMX	smx	NN	NN	_	9	nmod	_	_
12	to	to	TO	TO	_	15	case	_	_
13	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
14	toxic	toxic	JJ	JJ	_	15	amod	_	_
15	metabolites	metabolite	NNS	NNS	_	9	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	reduction	reduction	NN	NN	_	9	conj	_	_
19	is	be	VBZ	VBZ	_	24	cop	_	_
20	an	a	DT	DT	_	24	det	_	_
21	important	important	JJ	JJ	_	24	amod	_	_
22	protective	protective	JJ	JJ	_	24	amod	_	_
23	cellular	cellular	JJ	JJ	_	24	amod	_	_
24	mechanism	mechanism	NN	NN	_	4	ccomp	_	_
25	.	.	.	.	_	4	punct	_	_

1	If	if	IN	IN	_	4	mark	_	_
2	an	a	DT	DT	_	3	det	_	_
3	imbalance	imbalance	NN	NN	_	4	nsubj	_	_
4	exists	exist	VBZ	VBZ	_	21	advcl	_	_
5	,	,	,	,	_	21	punct	_	_
6	haptenation	haptenation	NN	NN	_	21	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	toxic	toxic	JJ	JJ	_	10	amod	_	_
10	metabolites	metabolite	NNS	NNS	_	6	nmod	_	_
11	to	to	TO	TO	_	13	case	_	_
12	bodily	bodily	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	6	nmod	_	_
14	including	include	VBG	VBG	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	surface	surface	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	viable	viable	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	can	can	MD	MD	_	21	aux	_	_
21	occur	occur	VB	VB	_	0	root	_	_
22	,	,	,	,	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	result	result	VB	VB	_	21	conj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	drug	drug	NN	NN	_	28	compound	_	_
28	hypersensitivity	hypersensitivity	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	21	punct	_	_

1	Leukocyte	leukocyte	NN	NN	_	2	compound	_	_
2	populations	population	NNS	NNS	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	hormone	hormone	NN	NN	_	5	compound	_	_
5	receptors	receptor	NNS	NNS	_	2	conj	_	_
6	and	and	CC	CC	_	2	cc	_	_
7	apoptosis	apoptosis	NN	NN	_	2	conj	_	_
8	in	in	IN	IN	_	9	case	_	_
9	eutopic	eutopic	JJ	JJ	_	2	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	ectopic	ectopic	JJ	JJ	_	9	conj	_	_
12	first	first	JJ	JJ	_	15	amod	_	_
13	trimester	trimester	NN	NN	_	15	compound	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	pregnancies	pregnancy	NNS	NNS	_	9	dep	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	implantation	implantation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	trophoblast	trophoblast	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	at	at	IN	IN	_	8	case	_	_
7	extrauterine	extrauterine	JJ	JJ	_	8	amod	_	_
8	sites	site	NNS	NNS	_	2	nmod	_	_
9	still	still	RB	RB	_	10	advmod	_	_
10	results	result	VBZ	VBZ	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	decidualization	decidualization	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	objective	objective	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	present	present	JJ	JJ	_	6	amod	_	_
6	study	study	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	compare	compare	VB	VB	_	7	xcomp	_	_
10	decidualization	decidualization	NN	NN	_	9	dobj	_	_
11	at	at	IN	IN	_	12	case	_	_
12	eutopic	eutopic	JJ	JJ	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	ectopic	ectopic	JJ	JJ	_	12	conj	_	_
15	implantation	implantation	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	12	dep	_	_
17	.	.	.	.	_	7	punct	_	_

1	Tissues	tissue	NNS	NNS	_	17	nsubjpass	_	_
2	from	from	IN	IN	_	3	case	_	_
3	women	woman	NNS	NNS	_	1	nmod	_	_
4	undergoing	undergo	VBG	VBG	_	3	acl	_	_
5	elective	elective	JJ	JJ	_	6	amod	_	_
6	termination	termination	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	uterine	uterine	JJ	JJ	_	9	amod	_	_
9	pregnancy	pregnancy	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	from	from	IN	IN	_	12	case	_	_
12	women	woman	NNS	NNS	_	3	conj	_	_
13	with	with	IN	IN	_	15	case	_	_
14	ectopic	ectopic	JJ	JJ	_	15	amod	_	_
15	pregnancy	pregnancy	NN	NN	_	12	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	used	use	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	detect	detect	VB	VB	_	17	xcomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	cells	cell	NNS	NNS	_	21	nmod	_	_
24	important	important	JJ	JJ	_	23	amod	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	maintenance	maintenance	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	pregnancy	pregnancy	NN	NN	_	27	nmod	_	_
30	,	,	,	,	_	23	punct	_	_
31	such	such	JJ	JJ	_	33	case	_	_
32	as	as	IN	IN	_	31	mwe	_	_
33	BCL-2+	bcl-2+	JJ	JJ	_	23	nmod	_	_
34	,	,	,	,	_	33	punct	_	_
35	CD56+	cd56+	JJ	JJ	_	33	conj	_	_
36	,	,	,	,	_	33	punct	_	_
37	CD3+	cd3+	JJ	JJ	_	33	conj	_	_
38	,	,	,	,	_	33	punct	_	_
39	CD8+	cd8+	JJ	JJ	_	33	conj	_	_
40	and	and	CC	CC	_	33	cc	_	_
41	CD68+	cd68+	JJ	JJ	_	33	conj	_	_
42	cells	cell	NNS	NNS	_	33	dep	_	_
43	,	,	,	,	_	21	punct	_	_
44	and	and	CC	CC	_	21	cc	_	_
45	the	the	DT	DT	_	46	det	_	_
46	presence	presence	NN	NN	_	21	conj	_	_
47	of	of	IN	IN	_	48	case	_	_
48	oestrogen	oestrogen	NN	NN	_	46	nmod	_	_
49	(	(	-LRB-	-LRB-	_	50	punct	_	_
50	ER	er	NN	NN	_	48	appos	_	_
51	)	)	-RRB-	-RRB-	_	50	punct	_	_
52	and	and	CC	CC	_	48	cc	_	_
53	progesterone	progesterone	NN	NN	_	54	compound	_	_
54	receptors	receptor	NNS	NNS	_	48	conj	_	_
55	(	(	-LRB-	-LRB-	_	56	punct	_	_
56	PR	pr	NN	NN	_	54	appos	_	_
57	)	)	-RRB-	-RRB-	_	56	punct	_	_
58	by	by	IN	IN	_	59	case	_	_
59	immunohistochemistry	immunohistochemistry	NN	NN	_	19	nmod	_	_
60	.	.	.	.	_	17	punct	_	_

1	In-situ	in-situ	FW	FW	_	2	compound	_	_
2	detection	detection	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	fragmented	fragmented	JJ	JJ	_	5	amod	_	_
5	DNA	dna	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	performed	perform	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	identify	identify	VB	VB	_	7	xcomp	_	_
10	apoptotic	apoptotic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	9	dobj	_	_
12	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	percentage	percentage	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	CD3+	cd3+	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	among	among	IN	IN	_	9	case	_	_
7	all	all	DT	DT	_	9	det	_	_
8	immunocompetent	immunocompetent	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	tubal	tubal	JJ	JJ	_	13	amod	_	_
13	epithelium	epithelium	NN	NN	_	2	nmod	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	46.6	46.6	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	0	root	_	_
17	(	(	-LRB-	-LRB-	_	24	punct	_	_
18	39.9	39.9	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	24	nsubj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CD3+	cd3+	JJ	JJ	_	19	nmod	_	_
22	were	be	VBD	VBD	_	24	cop	_	_
23	also	also	RB	RB	_	24	advmod	_	_
24	CD8+	cd8+	JJ	JJ	_	16	dep	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	;	;	:	:	_	16	punct	_	_
27	the	the	DT	DT	_	30	det	_	_
28	other	other	JJ	JJ	_	30	amod	_	_
29	53.4	53.4	CD	CD	_	30	nummod	_	_
30	%	%	NN	NN	_	33	nsubj	_	_
31	were	be	VBD	VBD	_	33	cop	_	_
32	CD68+	cd68+	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	16	parataxis	_	_
34	.	.	.	.	_	16	punct	_	_

1	CD56+	cd56+	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	cop	_	_
4	undetectable	undetectable	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	ectopic	ectopic	JJ	JJ	_	7	amod	_	_
7	decidua	decidua	NN	NN	_	4	nmod	_	_
8	at	at	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	feto-maternal	feto-maternal	JJ	JJ	_	11	amod	_	_
11	interface	interface	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	ectopic	ectopic	JJ	JJ	_	14	amod	_	_
14	tissue	tissue	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	uterine	uterine	JJ	JJ	_	3	amod	_	_
3	decidua	decidua	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	found	find	VBD	VBD	_	0	root	_	_
7	29.9	29.9	CD	CD	_	10	nummod	_	_
8	%	%	NN	NN	_	10	compound	_	_
9	CD3+	cd3+	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	dobj	_	_
11	(	(	-LRB-	-LRB-	_	17	punct	_	_
12	2.2	2.2	CD	CD	_	13	nummod	_	_
13	%	%	NN	NN	_	17	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	CD3+	cd3+	JJ	JJ	_	13	nmod	_	_
16	were	be	VBD	VBD	_	17	cop	_	_
17	CD8+	cd8+	JJ	JJ	_	10	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	10	punct	_	_
20	51.6	51.6	CD	CD	_	23	nummod	_	_
21	%	%	NN	NN	_	23	compound	_	_
22	CD56+	cd56+	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	10	conj	_	_
24	and	and	CC	CC	_	10	cc	_	_
25	18.5	18.5	CD	CD	_	28	nummod	_	_
26	%	%	NN	NN	_	28	compound	_	_
27	CD68+	cd68+	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	10	conj	_	_
29	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ratio	ratio	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	BCL2+	bcl2+	JJ	JJ	_	2	nmod	_	_
5	to	to	TO	TO	_	7	case	_	_
6	CD3+	cd3+	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	ectopic	ectopic	JJ	JJ	_	10	amod	_	_
10	pregnancy	pregnancy	NN	NN	_	2	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	0.41	0.41	CD	CD	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	uterine	uterine	JJ	JJ	_	3	amod	_	_
3	pregnancy	pregnancy	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	ratio	ratio	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	BCL-2	bcl-2	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	CD3	cd3	NN	NN	_	6	nmod	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	0.44	0.44	CD	CD	_	0	root	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	0.39	0.39	CD	CD	_	12	conj	_	_
15	for	for	IN	IN	_	16	case	_	_
16	CD56	cd56	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	12	punct	_	_

1	Tissues	tissue	NNS	NNS	_	9	nsubj	_	_
2	from	from	IN	IN	_	4	case	_	_
3	both	both	CC	CC	_	4	cc:preconj	_	_
4	ectopic	ectopic	JJ	JJ	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	uterine	uterine	JJ	JJ	_	4	conj	_	_
7	pregnancies	pregnancy	NNS	NNS	_	4	dep	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	positive	positive	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	PR	pr	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Fewer	fewer	JJR	JJR	_	4	amod	_	_
2	apoptotic	apoptotic	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	bodies	body	NNS	NNS	_	6	nsubj	_	_
5	were	be	VBD	VBD	_	6	cop	_	_
6	present	present	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	ectopic	ectopic	JJ	JJ	_	9	amod	_	_
9	pregnancy	pregnancy	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	use	use	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	tissue	tissue	NN	NN	_	2	nmod	_	_
5	obtained	obtain	VBN	VBN	_	4	acl	_	_
6	from	from	IN	IN	_	8	case	_	_
7	ectopic	ectopic	JJ	JJ	_	8	amod	_	_
8	pregnancy	pregnancy	NN	NN	_	5	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	become	become	VB	VB	_	0	root	_	_
11	an	a	DT	DT	_	13	det	_	_
12	excellent	excellent	JJ	JJ	_	13	amod	_	_
13	model	model	NN	NN	_	10	xcomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	identify	identify	VB	VB	_	13	acl	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mechanism	mechanism	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	trophoblast	trophoblast	NN	NN	_	20	compound	_	_
20	invasion	invasion	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	eutopic	eutopic	JJ	JJ	_	23	amod	_	_
23	pregnancies	pregnancy	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Tcf-1-mediated	tcf-1-mediated	JJ	JJ	_	2	amod	_	_
2	transcription	transcription	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	differential	differential	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	2	dep	_	_
9	for	for	IN	IN	_	12	case	_	_
10	glycogen	glycogen	NN	NN	_	12	compound	_	_
11	synthase	synthase	NN	NN	_	12	compound	_	_
12	kinase-3	kinase-3	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	fibroblasts	fibroblast	NNS	NNS	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Beta-catenin	beta-catenin	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	vertebrate	vertebrate	JJ	JJ	_	5	amod	_	_
5	homolog	homolog	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	12	case	_	_
7	the	the	DT	DT	_	12	det	_	_
8	Drosophila	drosophila	NN	NN	_	12	compound	_	_
9	segment	segment	NN	NN	_	12	compound	_	_
10	polarity	polarity	NN	NN	_	12	compound	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	Armadillo	armadillo	NN	NN	_	5	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	plays	play	VBZ	VBZ	_	5	conj	_	_
15	roles	role	NNS	NNS	_	14	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	both	both	CC	CC	_	19	cc:preconj	_	_
18	cell-cell	cell-cell	JJ	JJ	_	19	amod	_	_
19	adhesion	adhesion	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	transduction	transduction	NN	NN	_	19	conj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	Wnt	wnt	NN	NN	_	26	compound	_	_
25	signaling	signaling	NN	NN	_	26	compound	_	_
26	cascade	cascade	NN	NN	_	19	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Recently	recently	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	members	member	NNS	NNS	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Lef/Tcf	lef/tcf	NN	NN	_	9	compound	_	_
7	transcription	transcription	NN	NN	_	9	compound	_	_
8	factor	factor	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	3	nmod	_	_
10	have	have	VBP	VBP	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	identified	identify	VBN	VBN	_	0	root	_	_
13	as	as	IN	IN	_	15	case	_	_
14	protein	protein	NN	NN	_	15	compound	_	_
15	partners	partner	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	beta-catenin	beta-catenin	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	12	punct	_	_
19	explaining	explain	VBG	VBG	_	12	xcomp	_	_
20	how	how	WRB	WRB	_	22	advmod	_	_
21	beta-catenin	beta-catenin	NN	NN	_	22	nsubj	_	_
22	alters	alter	VBZ	VBZ	_	19	ccomp	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	Tcf-1	tcf-1	NN	NN	_	11	nsubj	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	becomes	become	VBZ	VBZ	_	3	ccomp	_	_
12	transcriptionally	transcriptionally	RB	RB	_	13	advmod	_	_
13	active	active	JJ	JJ	_	11	xcomp	_	_
14	through	through	IN	IN	_	15	case	_	_
15	interaction	interaction	NN	NN	_	11	nmod	_	_
16	with	with	IN	IN	_	17	case	_	_
17	beta-catenin	beta-catenin	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	suggesting	suggest	VBG	VBG	_	11	xcomp	_	_
20	that	that	IN	IN	_	27	mark	_	_
21	the	the	DT	DT	_	25	det	_	_
22	Wnt	wnt	NN	NN	_	25	compound	_	_
23	signal	signal	NN	NN	_	25	compound	_	_
24	transduction	transduction	NN	NN	_	25	compound	_	_
25	pathway	pathway	NN	NN	_	27	nsubj	_	_
26	is	be	VBZ	VBZ	_	27	cop	_	_
27	operational	operational	JJ	JJ	_	19	ccomp	_	_
28	in	in	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	27	nmod	_	_
31	as	as	RB	RB	_	32	advmod	_	_
32	well	well	RB	RB	_	27	advcl	_	_
33	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	33	advmod	_	_
2	,	,	,	,	_	33	punct	_	_
3	although	although	IN	IN	_	7	mark	_	_
4	Wnt	wnt	NN	NN	_	5	compound	_	_
5	signals	signal	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	known	know	VBN	VBN	_	33	advcl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	inhibit	inhibit	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	negative	negative	JJ	JJ	_	17	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	11	nmod	_	_
18	glycogen	glycogen	NN	NN	_	20	compound	_	_
19	synthase	synthase	NN	NN	_	20	compound	_	_
20	kinase-3beta	kinase-3beta	NN	NN	_	17	dep	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	GSK-3beta	gsk-3beta	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	9	punct	_	_
25	resulting	result	VBG	VBG	_	9	advcl	_	_
26	in	in	IN	IN	_	28	case	_	_
27	increased	increase	VBN	VBN	_	28	amod	_	_
28	levels	level	NNS	NNS	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	beta-catenin	beta-catenin	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	33	punct	_	_
32	we	we	PRP	PRP	_	33	nsubj	_	_
33	find	find	VBP	VBP	_	0	root	_	_
34	no	no	DT	DT	_	35	neg	_	_
35	evidence	evidence	NN	NN	_	33	dobj	_	_
36	for	for	IN	IN	_	37	case	_	_
37	involvement	involvement	NN	NN	_	35	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	GSK-3beta	gsk-3beta	NN	NN	_	37	nmod	_	_
40	in	in	IN	IN	_	42	case	_	_
41	Tcf-mediated	tcf-mediated	JJ	JJ	_	42	amod	_	_
42	transcription	transcription	NN	NN	_	37	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	33	punct	_	_

1	That	that	DT	DT	_	13	advmod	_	_
2	is	be	VBZ	VBZ	_	1	mwe	_	_
3	,	,	,	,	_	13	punct	_	_
4	a	a	DT	DT	_	13	dep	_	_
5	dominant	dominant	JJ	JJ	_	13	dep	_	_
6	negative	negative	JJ	JJ	_	13	dep	_	_
7	GSK-3beta	gsk-3beta	NN	NN	_	13	dep	_	_
8	does	do	VBZ	VBZ	_	13	dep	_	_
9	not	not	RB	RB	_	13	neg	_	_
10	specifically	specifically	RB	RB	_	13	advmod	_	_
11	activate	activate	VB	VB	_	13	dep	_	_
12	Tcf	tcf	NN	NN	_	13	dep	_	_
13	transcription	transcription	NN	NN	_	0	root	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	stimuli	stimulus	NNS	NNS	_	31	dep	_	_
16	(	(	-LRB-	-LRB-	_	31	punct	_	_
17	lithium	lithium	NN	NN	_	31	dep	_	_
18	or	or	CC	CC	_	31	cc	_	_
19	phytohemagglutinin	phytohemagglutinin	NN	NN	_	31	conj	_	_
20	)	)	-RRB-	-RRB-	_	31	punct	_	_
21	that	that	WDT	WDT	_	31	dep	_	_
22	inhibit	inhibit	VBP	VBP	_	31	dep	_	_
23	GSK-3beta	gsk-3beta	NN	NN	_	31	dep	_	_
24	activity	activity	NN	NN	_	31	dep	_	_
25	also	also	RB	RB	_	31	advmod	_	_
26	do	do	VBP	VBP	_	31	dep	_	_
27	not	not	RB	RB	_	31	neg	_	_
28	activate	activate	VB	VB	_	31	dep	_	_
29	Tcf	tcf	NN	NN	_	31	dep	_	_
30	reporter	reporter	NN	NN	_	31	dep	_	_
31	genes	gene	NNS	NNS	_	13	conj	_	_
32	.	.	.	.	_	13	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	inhibition	inhibition	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	GSK-3beta	gsk-3beta	NN	NN	_	3	nmod	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	insufficient	insufficient	JJ	JJ	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	xcomp	_	_
10	Tcf-dependent	tcf-dependent	JJ	JJ	_	11	amod	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	in	in	IN	IN	_	7	case	_	_
5	C57MG	c57mg	NN	NN	_	7	compound	_	_
6	fibroblast	fibroblast	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	10	nmod	_	_
8	,	,	,	,	_	10	punct	_	_
9	lithium	lithium	NN	NN	_	10	nsubj	_	_
10	inactivates	inactivate	VBZ	VBZ	_	0	root	_	_
11	GSK-3beta	gsk-3beta	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	10	cc	_	_
13	induces	induce	VBZ	VBZ	_	10	conj	_	_
14	Tcf-controlled	tcf-controlled	JJ	JJ	_	15	amod	_	_
15	transcription	transcription	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	demonstration	demonstration	NN	NN	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	lithium	lithium	NN	NN	_	9	nsubj	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	alter	alter	VB	VB	_	5	dep	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Tcf-responsive	tcf-responsive	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	points	point	VBZ	VBZ	_	5	conj	_	_
18	to	to	TO	TO	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	difference	difference	NN	NN	_	17	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	regulation	regulation	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	Wnt	wnt	NN	NN	_	25	compound	_	_
25	signaling	signaling	NN	NN	_	22	nmod	_	_
26	between	between	IN	IN	_	27	case	_	_
27	fibroblasts	fibroblast	NNS	NNS	_	20	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	27	conj	_	_
30	.	.	.	.	_	5	punct	_	_

1	CIITA-induced	ciita-induced	JJ	JJ	_	2	amod	_	_
2	occupation	occupation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	MHC	mhc	NN	NN	_	7	compound	_	_
5	class	class	NN	NN	_	7	compound	_	_
6	II	ii	CD	CD	_	7	nummod	_	_
7	promoters	promoter	NNS	NNS	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	independent	independent	JJ	JJ	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
13	stabilization	stabilization	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	promoter-bound	promoter-bound	JJ	JJ	_	18	amod	_	_
17	multi-protein	multi-protein	JJ	JJ	_	18	amod	_	_
18	complexes	complex	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Precise	precise	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	MHC	mhc	NN	NN	_	7	compound	_	_
5	class	class	NN	NN	_	7	compound	_	_
6	II	ii	CD	CD	_	7	nummod	_	_
7	expression	expression	NN	NN	_	2	nmod	_	_
8	plays	play	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	crucial	crucial	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	control	control	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transactivator	transactivator	NN	NN	_	3	compound	_	_
3	CIITA	ciita	NN	NN	_	4	nsubj	_	_
4	behaves	behave	VBZ	VBZ	_	0	root	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	master	master	JJ	JJ	_	8	amod	_	_
8	controller	controller	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	17	case	_	_
10	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	inducible	inducible	JJ	JJ	_	10	conj	_	_
13	MHC	mhc	NN	NN	_	17	compound	_	_
14	class	class	NN	NN	_	17	compound	_	_
15	II	ii	CD	CD	_	17	nummod	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	activation	activation	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	but	but	CC	CC	_	4	cc	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	exact	exact	JJ	JJ	_	22	amod	_	_
22	mechanism	mechanism	NN	NN	_	27	nsubjpass	_	_
23	of	of	IN	IN	_	24	case	_	_
24	action	action	NN	NN	_	22	nmod	_	_
25	is	be	VBZ	VBZ	_	27	auxpass	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	known	know	VBN	VBN	_	4	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	MHC	mhc	NN	NN	_	6	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	II	ii	CD	CD	_	6	nummod	_	_
6	promoters	promoter	NNS	NNS	_	1	nmod	_	_
7	requires	require	VBZ	VBZ	_	0	root	_	_
8	binding	binding	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	15	case	_	_
10	at	at	IN	IN	_	11	case	_	_
11	least	least	JJS	JJS	_	12	nmod:npmod	_	_
12	three	three	CD	CD	_	15	nummod	_	_
13	distinct	distinct	JJ	JJ	_	15	amod	_	_
14	multi-protein	multi-protein	JJ	JJ	_	15	amod	_	_
15	complexes	complex	NNS	NNS	_	8	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	RFX	rfx	NN	NN	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	X2BP	x2bp	NN	NN	_	17	conj	_	_
20	and	and	CC	CC	_	17	cc	_	_
21	NF-Y	nf-y	NN	NN	_	17	conj	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	stability	stability	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	this	this	DT	DT	_	9	det	_	_
9	binding	binding	NN	NN	_	6	nmod	_	_
10	results	result	VBZ	VBZ	_	3	ccomp	_	_
11	from	from	IN	IN	_	13	case	_	_
12	cooperative	cooperative	JJ	JJ	_	13	amod	_	_
13	interactions	interaction	NNS	NNS	_	10	nmod	_	_
14	between	between	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	proteins	protein	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	expression	expression	NN	NN	_	12	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CIITA	ciita	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	MHC	mhc	NN	NN	_	11	compound	_	_
10	class	class	NN	NN	_	11	compound	_	_
11	II-cells	ii-cell	NNS	NNS	_	5	nmod	_	_
12	triggers	trigger	VBZ	VBZ	_	2	ccomp	_	_
13	occupation	occupation	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	promoters	promoter	NNS	NNS	_	13	nmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	these	these	DT	DT	_	19	det	_	_
19	complexes	complex	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	3	nsubj	_	_
3	raised	raise	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	possibility	possibility	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effect	effect	NN	NN	_	15	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CIITA	ciita	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	occupation	occupation	NN	NN	_	8	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	5	dep	_	_
16	by	by	IN	IN	_	18	case	_	_
17	an	a	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	15	nmod	_	_
19	on	on	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cooperative	cooperative	JJ	JJ	_	22	amod	_	_
22	stabilization	stabilization	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	DNA-bound	dna-bound	JJ	JJ	_	27	amod	_	_
26	multi-protein	multi-protein	JJ	JJ	_	27	amod	_	_
27	complexes	complex	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	however	however	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	presence	presence	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	CIITA	ciita	NN	NN	_	8	nmod	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affect	affect	VB	VB	_	2	ccomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	stability	stability	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	higher-order	higher-order	JJ	JJ	_	20	amod	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	15	nmod	_	_
21	formed	form	VBN	VBN	_	20	acl	_	_
22	on	on	IN	IN	_	23	case	_	_
23	DNA	dna	NN	NN	_	21	nmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	RFX	rfx	NN	NN	_	21	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	X2BP	x2bp	NN	NN	_	25	conj	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	NF-Y	nf-y	NN	NN	_	25	conj	_	_
30	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	suggests	suggest	VBZ	VBZ	_	0	root	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	for	for	IN	IN	_	8	case	_	_
6	CIITA-induced	ciita-induced	JJ	JJ	_	8	amod	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	occupancy	occupancy	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	4	punct	_	_
10	such	such	JJ	JJ	_	13	case	_	_
11	as	as	IN	IN	_	10	mwe	_	_
12	an	a	DT	DT	_	13	det	_	_
13	effect	effect	NN	NN	_	4	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	chromatin	chromatin	NN	NN	_	16	compound	_	_
16	structure	structure	NN	NN	_	13	nmod	_	_
17	leading	lead	VBG	VBG	_	13	acl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	increased	increase	VBN	VBN	_	20	amod	_	_
20	accessibility	accessibility	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	MHC	mhc	NN	NN	_	25	compound	_	_
23	class	class	NN	NN	_	25	compound	_	_
24	II	ii	CD	CD	_	25	nummod	_	_
25	promoters	promoter	NNS	NNS	_	20	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CIITA	ciita	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	facilitate	facilitate	VB	VB	_	2	acl	_	_
7	promoter	promoter	NN	NN	_	8	compound	_	_
8	occupation	occupation	NN	NN	_	6	dobj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	undissociable	undissociable	JJ	JJ	_	0	root	_	_
11	from	from	IN	IN	_	14	case	_	_
12	its	its	PRP$	PRP$	_	14	nmod:poss	_	_
13	transactivation	transactivation	NN	NN	_	14	compound	_	_
14	potential	potential	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	conclude	conclude	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	this	this	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CIITA	ciita	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	cell-type	cell-type	JJ	JJ	_	12	amod	_	_
12	specific	specific	JJ	JJ	_	4	ccomp	_	_
13	,	,	,	,	_	4	punct	_	_
14	since	since	IN	IN	_	20	mark	_	_
15	expression	expression	NN	NN	_	20	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CIITA	ciita	NN	NN	_	15	nmod	_	_
18	is	be	VBZ	VBZ	_	20	auxpass	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	required	require	VBN	VBN	_	4	advcl	_	_
21	for	for	IN	IN	_	23	case	_	_
22	normal	normal	JJ	JJ	_	23	amod	_	_
23	occupation	occupation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	28	case	_	_
25	MHC	mhc	NN	NN	_	28	compound	_	_
26	class	class	NN	NN	_	28	compound	_	_
27	II	ii	CD	CD	_	28	nummod	_	_
28	promoters	promoter	NNS	NNS	_	23	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	23	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	Immunosuppressant	immunosuppressant	JJ	JJ	_	6	nsubj	_	_
2	PG490	pg490	NN	NN	_	1	dep	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	triptolide	triptolide	NN	NN	_	1	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
7	T-cell	t-cell	NN	NN	_	9	compound	_	_
8	interleukin-2	interleukin-2	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	at	at	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	level	level	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	purine-box/nuclear	purine-box/nuclear	JJ	JJ	_	15	amod	_	_
15	factor	factor	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	activated	activate	VBN	VBN	_	18	amod	_	_
18	T-cells	t-cell	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
21	transcriptional	transcriptional	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	6	punct	_	_

1	PG490	pg490	NN	NN	_	8	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	triptolide	triptolide	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	is	be	VBZ	VBZ	_	8	cop	_	_
6	a	a	DT	DT	_	8	det	_	_
7	diterpene	diterpene	JJ	JJ	_	8	amod	_	_
8	triepoxide	triepoxide	NN	NN	_	0	root	_	_
9	with	with	IN	IN	_	11	case	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	immunosuppressive	immunosuppressive	JJ	JJ	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	antiinflammatory	antiinflammatory	JJ	JJ	_	11	conj	_	_
14	properties	property	NNS	NNS	_	11	dep	_	_
15	.	.	.	.	_	8	punct	_	_

1	PG490	pg490	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	interleukin	interleukin	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	IL	il	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-2	-2	CD	CD	_	8	nummod	_	_
8	expression	expression	NN	NN	_	2	dobj	_	_
9	by	by	IN	IN	_	14	case	_	_
10	normal	normal	JJ	JJ	_	14	amod	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	peripheral	peripheral	JJ	JJ	_	14	amod	_	_
13	blood	blood	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
15	stimulated	stimulate	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	phorbol	phorbol	NN	NN	_	19	compound	_	_
18	12-myristate	12-myristate	NN	NN	_	19	compound	_	_
19	13-acetate	13-acetate	NN	NN	_	15	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	antibody	antibody	NN	NN	_	19	conj	_	_
25	to	to	TO	TO	_	26	case	_	_
26	CD3	cd3	NN	NN	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	IC50	ic50	NN	NN	_	19	dep	_	_
29	of	of	IN	IN	_	31	case	_	_
30	10	10	CD	CD	_	31	nummod	_	_
31	ng/ml	ng/ml	NN	NN	_	28	nmod	_	_
32	)	)	-RRB-	-RRB-	_	28	punct	_	_
33	,	,	,	,	_	19	punct	_	_
34	and	and	CC	CC	_	19	cc	_	_
35	with	with	IN	IN	_	36	case	_	_
36	PMA	pma	NN	NN	_	19	conj	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	ionomycin	ionomycin	NN	NN	_	36	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	Iono	iono	NN	NN	_	36	dep	_	_
41	,	,	,	,	_	40	punct	_	_
42	IC50	ic50	NN	NN	_	40	appos	_	_
43	of	of	IN	IN	_	45	case	_	_
44	40	40	CD	CD	_	45	nummod	_	_
45	ng/ml	ng/ml	NN	NN	_	42	nmod	_	_
46	)	)	-RRB-	-RRB-	_	40	punct	_	_
47	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	Jurkat	jurkat	NN	NN	_	3	compound	_	_
3	T-cells	t-cell	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	PG490	pg490	NN	NN	_	6	nsubj	_	_
6	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
7	PMA/Iono-stimulated	pma/iono-stimulated	JJ	JJ	_	9	amod	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	transcription	transcription	NN	NN	_	6	dobj	_	_
10	.	.	.	.	_	6	punct	_	_

1	PG490	pg490	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	induction	induction	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	4	nmod	_	_
9	at	at	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	purine-box	purine-box	NN	NN	_	2	nmod	_	_
12	/	/	:	:	_	11	punct	_	_
13	antigen	antigen	NN	NN	_	16	compound	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	11	dep	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	ARRE	arre	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	/	/	:	:	_	11	punct	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	30	compound	_	_
23	of	of	IN	IN	_	25	case	_	_
24	activated	activate	VBN	VBN	_	25	amod	_	_
25	T-cells	t-cell	NNS	NNS	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	NF-AT	nf-at	NN	NN	_	22	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	target	target	NN	NN	_	30	compound	_	_
30	sequence	sequence	NN	NN	_	11	dep	_	_
31	but	but	CC	CC	_	11	cc	_	_
32	not	not	RB	RB	_	36	neg	_	_
33	at	at	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	NF-kappaB	nf-kappab	NN	NN	_	36	compound	_	_
36	site	site	NN	NN	_	11	conj	_	_
37	.	.	.	.	_	2	punct	_	_

1	PG490	pg490	NN	NN	_	4	nsubj	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	completely	completely	RB	RB	_	4	advmod	_	_
4	inhibit	inhibit	VB	VB	_	0	root	_	_
5	transcriptional	transcriptional	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	at	at	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	dep	_	_
9	purine-box/ARRE/NF-AT	purine-box/arre/nf-at	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	conj	_	_
12	target	target	NN	NN	_	14	compound	_	_
13	DNA	dna	NN	NN	_	14	compound	_	_
14	sequences	sequence	NNS	NNS	_	9	dep	_	_
15	triggered	trigger	VBN	VBN	_	9	dep	_	_
16	by	by	IN	IN	_	18	case	_	_
17	all	all	DT	DT	_	18	det	_	_
18	stimuli	stimulus	NNS	NNS	_	15	nmod	_	_
19	examined	examine	VBN	VBN	_	18	acl	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	18	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	PMA/Iono	pma/iono	NN	NN	_	21	appos	_	_
24	,	,	,	,	_	21	punct	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor-alpha	factor-alpha	NN	NN	_	21	appos	_	_
28	)	)	-RRB-	-RRB-	_	21	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	PG490	pg490	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	PMA-stimulated	pma-stimulated	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	chimeric	chimeric	JJ	JJ	_	10	amod	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factor	factor	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	22	nmod	_	_
13	the	the	DT	DT	_	17	det	_	_
14	C-terminal	c-terminal	JJ	JJ	_	17	amod	_	_
15	TA1	ta1	NN	NN	_	17	compound	_	_
16	transactivation	transactivation	NN	NN	_	17	compound	_	_
17	domain	domain	NN	NN	_	22	nsubjpass	_	_
18	of	of	IN	IN	_	20	case	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	p65	p65	NN	NN	_	17	nmod	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	fused	fuse	VBN	VBN	_	10	acl:relcl	_	_
23	to	to	TO	TO	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	DNA	dna	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	domain	domain	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	GAL4	gal4	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	16HBE	16hbe	NN	NN	_	6	compound	_	_
3	human	human	JJ	JJ	_	6	amod	_	_
4	bronchial	bronchial	JJ	JJ	_	6	amod	_	_
5	epithelial	epithelial	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	11	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	IL-8	il-8	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	predominantly	predominantly	RB	RB	_	11	advmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	PG490	pg490	NN	NN	_	24	nsubj	_	_
18	but	but	CC	CC	_	17	cc	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	cyclosporin	cyclosporin	NN	NN	_	21	compound	_	_
21	A	a	NN	NN	_	17	conj	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	completely	completely	RB	RB	_	24	advmod	_	_
24	inhibit	inhibit	VB	VB	_	11	conj	_	_
25	expression	expression	NN	NN	_	24	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	IL-8	il-8	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PG490	pg490	NN	NN	_	5	compound	_	_
5	inhibition	inhibition	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	cytokine	cytokine	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	differs	differ	VBZ	VBZ	_	0	root	_	_
11	from	from	IN	IN	_	13	case	_	_
12	cyclosporin	cyclosporin	NN	NN	_	13	compound	_	_
13	A	a	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	involves	involve	VBZ	VBZ	_	10	conj	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	inhibition	inhibition	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	transcriptional	transcriptional	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	17	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	purine-box	purine-box	JJ	JJ	_	26	amod	_	_
26	regulator	regulator	NN	NN	_	17	conj	_	_
27	operating	operate	VBG	VBG	_	26	amod	_	_
28	at	at	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	ARRE/NF-AT	arre/nf-at	NN	NN	_	31	compound	_	_
31	site	site	NN	NN	_	26	nmod	_	_
32	at	at	IN	IN	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	step	step	NN	NN	_	26	nmod	_	_
35	after	after	IN	IN	_	38	case	_	_
36	specific	specific	JJ	JJ	_	38	amod	_	_
37	DNA	dna	NN	NN	_	38	compound	_	_
38	binding	binding	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	10	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Smad6	smad6	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Smad7	smad7	NN	NN	_	4	conj	_	_
7	on	on	IN	IN	_	10	case	_	_
8	bone	bone	NN	NN	_	10	compound	_	_
9	morphogenetic	morphogenetic	JJ	JJ	_	10	amod	_	_
10	protein-	protein-	NN	NN	_	2	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	activin-mediated	activin-mediated	JJ	JJ	_	14	amod	_	_
13	growth	growth	NN	NN	_	14	compound	_	_
14	arrest	arrest	NN	NN	_	10	conj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	apoptosis	apoptosis	NN	NN	_	10	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	10	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Smad6	smad6	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Smad7	smad7	NN	NN	_	1	conj	_	_
4	prevent	prevent	VBP	VBP	_	0	root	_	_
5	ligand-induced	ligand-induced	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	signal-transducing	signal-transducing	JJ	JJ	_	10	amod	_	_
9	Smad	smad	NN	NN	_	10	compound	_	_
10	proteins	protein	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	transforming	transform	VBG	VBG	_	16	amod	_	_
14	growth	growth	NN	NN	_	16	compound	_	_
15	factor-beta	factor-beta	NN	NN	_	16	compound	_	_
16	family	family	NN	NN	_	10	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	Smad6	smad6	NN	NN	_	18	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Smad7	smad7	NN	NN	_	6	conj	_	_
9	are	be	VBP	VBP	_	18	cop	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	bone	bone	NN	NN	_	13	compound	_	_
12	morphogenetic	morphogenetic	JJ	JJ	_	13	amod	_	_
13	protein-2	protein-2	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	hBMP-2	hbmp-2	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	-inducible	-inducible	JJ	JJ	_	18	amod	_	_
18	antagonists	antagonist	NNS	NNS	_	3	ccomp	_	_
19	of	of	IN	IN	_	22	case	_	_
20	hBMP-2-induced	hbmp-2-induced	JJ	JJ	_	22	amod	_	_
21	growth	growth	NN	NN	_	22	compound	_	_
22	arrest	arrest	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	apoptosis	apoptosis	NN	NN	_	22	conj	_	_
25	in	in	IN	IN	_	29	case	_	_
26	mouse	mouse	NN	NN	_	29	compound	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	hybridoma	hybridoma	NN	NN	_	22	nmod	_	_
30	HS-72	hs-72	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	29	dep	_	_
32	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	confirmed	confirm	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	ectopic	ectopic	JJ	JJ	_	8	amod	_	_
8	expressions	expression	NNS	NNS	_	13	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Smad6	smad6	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Smad7	smad7	NN	NN	_	10	conj	_	_
13	inhibited	inhibit	VBD	VBD	_	4	ccomp	_	_
14	the	the	DT	DT	_	17	det	_	_
15	hBMP-2-induced	hbmp-2-induced	JJ	JJ	_	17	amod	_	_
16	Smad1/Smad5	smad1/smad5	NN	NN	_	17	compound	_	_
17	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	previously	previously	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	Smad7	smad7	NN	NN	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	an	a	DT	DT	_	10	det	_	_
8	activin	activin	NN	NN	_	10	compound	_	_
9	A-inducible	a-inducible	JJ	JJ	_	10	amod	_	_
10	antagonist	antagonist	NN	NN	_	3	ccomp	_	_
11	of	of	IN	IN	_	15	case	_	_
12	activin	activin	NN	NN	_	15	compound	_	_
13	A-induced	a-induced	JJ	JJ	_	15	amod	_	_
14	growth	growth	NN	NN	_	15	compound	_	_
15	arrest	arrest	NN	NN	_	10	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	apoptosis	apoptosis	NN	NN	_	15	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	HS-72	hs-72	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Interestingly	interestingly	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	although	although	IN	IN	_	9	mark	_	_
4	mRNA	mrna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Smad6	smad6	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	18	advcl	_	_
10	by	by	IN	IN	_	12	case	_	_
11	activin	activin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	HS-72	hs-72	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	Smad6	smad6	NN	NN	_	18	nsubj	_	_
18	showed	show	VBD	VBD	_	0	root	_	_
19	no	no	DT	DT	_	21	neg	_	_
20	antagonistic	antagonistic	JJ	JJ	_	21	amod	_	_
21	effect	effect	NN	NN	_	18	dobj	_	_
22	on	on	IN	IN	_	26	case	_	_
23	activin	activin	NN	NN	_	26	compound	_	_
24	A-induced	a-induced	JJ	JJ	_	26	amod	_	_
25	growth	growth	NN	NN	_	26	compound	_	_
26	arrest	arrest	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	apoptosis	apoptosis	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	18	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	found	find	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	ectopic	ectopic	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	16	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Smad7	smad7	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	10	cc	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	Smad6	smad6	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	16	punct	_	_
16	inhibited	inhibit	VBD	VBD	_	4	ccomp	_	_
17	the	the	DT	DT	_	21	det	_	_
18	activin	activin	NN	NN	_	21	compound	_	_
19	A-induced	a-induced	JJ	JJ	_	21	amod	_	_
20	Smad2	smad2	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	16	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	HS-72	hs-72	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Thus	thus	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	Smad6	smad6	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Smad7	smad7	NN	NN	_	3	conj	_	_
6	exhibit	exhibit	VBP	VBP	_	0	root	_	_
7	differential	differential	JJ	JJ	_	9	amod	_	_
8	inhibitory	inhibitory	JJ	JJ	_	9	amod	_	_
9	effects	effect	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	bone	bone	NN	NN	_	13	compound	_	_
12	morphogenetic	morphogenetic	JJ	JJ	_	13	amod	_	_
13	protein-2-	protein-2-	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	activin	activin	NN	NN	_	17	compound	_	_
16	A-mediated	a-mediated	JJ	JJ	_	17	amod	_	_
17	signaling	signaling	NN	NN	_	13	conj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	B	b	NN	NN	_	21	compound	_	_
20	lineage	lineage	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	6	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	6	nsubj	_	_
3	Sp1	sp1	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	AP-2	ap-2	NN	NN	_	3	conj	_	_
6	mediate	mediate	VBP	VBP	_	0	root	_	_
7	induction	induction	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	acid	acid	NN	NN	_	10	compound	_	_
10	sphingomyelinase	sphingomyelinase	NN	NN	_	7	nmod	_	_
11	during	during	IN	IN	_	13	case	_	_
12	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Cells	cell	NNS	NNS	_	10	nsubj	_	_
2	from	from	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	monocytic	monocytic	JJ	JJ	_	8	amod	_	_
6	leukemia	leukemia	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	line	line	NN	NN	_	1	nmod	_	_
9	THP-1	thp-1	NN	NN	_	8	dep	_	_
10	differentiate	differentiate	VBP	VBP	_	0	root	_	_
11	towards	towards	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	macrophage-like	macrophage-like	JJ	JJ	_	14	amod	_	_
14	phenotype	phenotype	NN	NN	_	10	nmod	_	_
15	when	when	WRB	WRB	_	16	advmod	_	_
16	stimulated	stimulate	VBN	VBN	_	10	advcl	_	_
17	with	with	IN	IN	_	19	case	_	_
18	phorbol	phorbol	NN	NN	_	19	compound	_	_
19	12-myristate-13-acetate	12-myristate-13-acetate	NN	NN	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	PMA	pma	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	19	punct	_	_
24	1,25-dihydroxy-vitamin	1,25-dihydroxy-vitamin	NN	NN	_	25	compound	_	_
25	D3	d3	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	various	various	JJ	JJ	_	30	amod	_	_
29	other	other	JJ	JJ	_	30	amod	_	_
30	agents	agent	NNS	NNS	_	19	conj	_	_
31	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	19	nsubjpass	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	lysosomal	lysosomal	JJ	JJ	_	10	amod	_	_
10	enzyme	enzyme	NN	NN	_	6	nmod	_	_
11	acid	acid	NN	NN	_	12	compound	_	_
12	sphingomyelinase	sphingomyelinase	NN	NN	_	10	dep	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	ASM	asm	NN	NN	_	10	appos	_	_
15	;	;	:	:	_	14	punct	_	_
16	E.C.3.1.4.12	e.c.3.1.4.12	NN	NN	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	14	punct	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	induced	induce	VBN	VBN	_	2	ccomp	_	_
20	during	during	IN	IN	_	22	case	_	_
21	this	this	DT	DT	_	22	det	_	_
22	process	process	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	is	be	VBZ	VBZ	_	26	aux	_	_
25	strongly	strongly	RB	RB	_	26	advmod	_	_
26	elevated	elevated	JJ	JJ	_	19	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	differentiated	differentiate	VBN	VBN	_	30	amod	_	_
29	THP-1	thp-1	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	advcl	_	_
31	,	,	,	,	_	30	punct	_	_
32	as	as	RB	RB	_	30	dep	_	_
33	well	well	RB	RB	_	30	dep	_	_
34	as	as	IN	IN	_	30	case	_	_
35	in	in	IN	IN	_	39	case	_	_
36	differentiated	differentiate	VBN	VBN	_	39	amod	_	_
37	human	human	JJ	JJ	_	39	amod	_	_
38	mononuclear	mononuclear	JJ	JJ	_	39	amod	_	_
39	phagocytes	phagocyte	NNS	NNS	_	30	dep	_	_
40	.	.	.	.	_	2	punct	_	_

1	Using	use	VBG	VBG	_	15	advcl	_	_
2	Northern	northern	NN	NN	_	3	compound	_	_
3	blotting	blotting	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	3	punct	_	_
5	RNase	rnase	NN	NN	_	7	compound	_	_
6	protection	protection	NN	NN	_	7	compound	_	_
7	assay	assay	NN	NN	_	3	conj	_	_
8	,	,	,	,	_	3	punct	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	run-on	run-on	JJ	JJ	_	12	amod	_	_
12	analyses	analysis	NNS	NNS	_	3	conj	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	show	show	VBP	VBP	_	0	root	_	_
16	that	that	IN	IN	_	23	mark	_	_
17	the	the	DT	DT	_	18	det	_	_
18	up-regulation	up-regulation	NN	NN	_	23	nsubjpass	_	_
19	of	of	IN	IN	_	21	case	_	_
20	ASM	asm	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	18	nmod	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	regulated	regulate	VBN	VBN	_	15	ccomp	_	_
24	mainly	mainly	RB	RB	_	23	advmod	_	_
25	at	at	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	level	level	NN	NN	_	23	nmod	_	_
28	of	of	IN	IN	_	29	case	_	_
29	transcription	transcription	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	that	that	IN	IN	_	36	mark	_	_
32	new	new	JJ	JJ	_	34	amod	_	_
33	protein	protein	NN	NN	_	34	compound	_	_
34	synthesis	synthesis	NN	NN	_	36	nsubjpass	_	_
35	is	be	VBZ	VBZ	_	36	auxpass	_	_
36	required	require	VBN	VBN	_	23	conj	_	_
37	for	for	IN	IN	_	40	case	_	_
38	enhanced	enhance	VBN	VBN	_	40	amod	_	_
39	ASM	asm	NN	NN	_	40	compound	_	_
40	activity	activity	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	cell-type	cell-type	JJ	JJ	_	4	amod	_	_
3	specific	specific	JJ	JJ	_	4	amod	_	_
4	induction	induction	NN	NN	_	10	nsubjpass	_	_
5	by	by	IN	IN	_	7	case	_	_
6	PMA	pma	NN	NN	_	7	compound	_	_
7	treatment	treatment	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	further	further	RB	RB	_	10	advmod	_	_
10	investigated	investigate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	12	case	_	_
12	respect	respect	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	control	control	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	series	series	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	5'	5'	JJ	JJ	_	6	amod	_	_
5	deletion	deletion	NN	NN	_	6	compound	_	_
6	derivatives	derivative	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	upstream	upstream	JJ	JJ	_	11	amod	_	_
10	regulatory	regulatory	JJ	JJ	_	11	amod	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	used	use	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	17	case	_	_
15	transient	transient	JJ	JJ	_	17	amod	_	_
16	transfection	transfection	NN	NN	_	17	compound	_	_
17	assays	assay	NNS	NNS	_	13	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	identify	identify	VB	VB	_	13	xcomp	_	_
20	promoter	promoter	NN	NN	_	21	compound	_	_
21	elements	element	NNS	NNS	_	19	dobj	_	_
22	required	require	VBN	VBN	_	21	acl	_	_
23	for	for	IN	IN	_	28	case	_	_
24	basal	basal	JJ	JJ	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	inducible	inducible	JJ	JJ	_	24	conj	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	22	nmod	_	_
29	.	.	.	.	_	13	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	PMA	pma	NN	NN	_	4	compound	_	_
3	responsive	responsive	JJ	JJ	_	4	amod	_	_
4	element	element	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	aux	_	_
6	localized	localized	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	region	region	NN	NN	_	6	nmod	_	_
10	between	between	IN	IN	_	14	case	_	_
11	-319	-319	CD	CD	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	-219	-219	CD	CD	_	11	conj	_	_
14	bp	bp	NN	NN	_	9	nmod	_	_
15	upstream	upstream	RB	RB	_	14	advmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	initiation	initiation	NN	NN	_	19	compound	_	_
19	codon	codon	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	6	cc	_	_
21	co-transfections	co-transfection	NNS	NNS	_	31	nsubj	_	_
22	with	with	IN	IN	_	26	case	_	_
23	transcription	transcription	NN	NN	_	26	compound	_	_
24	factor	factor	NN	NN	_	26	compound	_	_
25	expression	expression	NN	NN	_	26	compound	_	_
26	plasmids	plasmid	NNS	NNS	_	21	nmod	_	_
27	for	for	IN	IN	_	28	case	_	_
28	AP-2	ap-2	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	Sp1	sp1	NN	NN	_	28	conj	_	_
31	resulted	result	VBD	VBD	_	6	conj	_	_
32	in	in	IN	IN	_	36	case	_	_
33	augmented	augmented	JJ	JJ	_	36	amod	_	_
34	ASM	asm	NN	NN	_	36	compound	_	_
35	promoter	promoter	NN	NN	_	36	compound	_	_
36	activity	activity	NN	NN	_	31	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	which	which	WDT	WDT	_	40	nsubjpass	_	_
39	was	be	VBD	VBD	_	40	auxpass	_	_
40	abolished	abolish	VBN	VBN	_	36	acl:relcl	_	_
41	when	when	WRB	WRB	_	50	advmod	_	_
42	the	the	DT	DT	_	44	det	_	_
43	binding	bind	VBG	VBG	_	44	amod	_	_
44	sites	site	NNS	NNS	_	50	nsubjpass	_	_
45	for	for	IN	IN	_	48	case	_	_
46	these	these	DT	DT	_	48	det	_	_
47	two	two	CD	CD	_	48	nummod	_	_
48	factors	factor	NNS	NNS	_	44	nmod	_	_
49	were	be	VBD	VBD	_	50	auxpass	_	_
50	deleted	delete	VBN	VBN	_	40	advcl	_	_
51	.	.	.	.	_	6	punct	_	_

1	Using	use	VBG	VBG	_	10	dep	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	1	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	supershift	supershift	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	5	conj	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	this	this	DT	DT	_	13	det	_	_
13	region	region	NN	NN	_	16	nsubjpass	_	_
14	is	be	VBZ	VBZ	_	16	auxpass	_	_
15	specifically	specifically	RB	RB	_	16	advmod	_	_
16	bound	bind	VBN	VBN	_	10	ccomp	_	_
17	by	by	IN	IN	_	18	case	_	_
18	Sp1	sp1	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	AP-2	ap-2	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	factors	factor	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	present	present	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	4	nmod	_	_
8	prepared	prepare	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	15	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	induced	induce	VBN	VBN	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	uninduced	uninduced	JJ	JJ	_	11	conj	_	_
14	THP-1	thp-1	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	intensity	intensity	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	complex	complex	NN	NN	_	4	nmod	_	_
8	formed	form	VBN	VBN	_	7	amod	_	_
9	appeared	appear	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	increase	increase	VB	VB	_	9	xcomp	_	_
12	when	when	WRB	WRB	_	19	advmod	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	19	nsubjpass	_	_
15	from	from	IN	IN	_	17	case	_	_
16	PMA-treated	pma-treated	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	used	use	VBN	VBN	_	11	advcl	_	_
20	.	.	.	.	_	9	punct	_	_

1	From	from	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	studies	study	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	conclude	conclude	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	19	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	concerted	concerted	JJ	JJ	_	10	amod	_	_
10	action	action	NN	NN	_	19	nsubj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	AP-2	ap-2	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Sp1	sp1	NN	NN	_	15	conj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	essential	essential	JJ	JJ	_	6	ccomp	_	_
20	for	for	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	up-regulation	up-regulation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	ASM	asm	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	during	during	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	process	process	NN	NN	_	19	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	macrophage	macrophage	NN	NN	_	31	compound	_	_
31	differentiation	differentiation	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	Estrogen	estrogen	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	progesterone	progesterone	NN	NN	_	1	conj	_	_
4	induction	induction	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	survival	survival	NN	NN	_	4	acl	_	_
7	of	of	IN	IN	_	9	case	_	_
8	monoblastoid	monoblastoid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	undergoing	undergo	VBG	VBG	_	9	acl	_	_
11	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Induction	induction	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	mononucleated	mononucleated	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	physiological	physiological	JJ	JJ	_	10	amod	_	_
10	process	process	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	12	mark	_	_
12	regulating	regulate	VBG	VBG	_	10	acl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	intensity	intensity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	female	female	JJ	JJ	_	4	amod	_	_
3	steroid	steroid	NN	NN	_	4	compound	_	_
4	hormones	hormone	NNS	NNS	_	15	nsubjpass	_	_
5	estrogen	estrogen	NN	NN	_	4	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	E2	e2	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	progesterone	progesterone	NN	NN	_	4	conj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	Prog	prog	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	known	know	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	modulate	modulate	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	reactivity	reactivity	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	system	system	NN	NN	_	19	nmod	_	_
24	;	;	:	:	_	15	punct	_	_
25	recently	recently	RB	RB	_	29	advmod	_	_
26	it	it	PRP	PRP	_	29	nsubjpass	_	_
27	has	have	VBZ	VBZ	_	29	aux	_	_
28	been	be	VBN	VBN	_	29	auxpass	_	_
29	demonstrated	demonstrate	VBN	VBN	_	15	parataxis	_	_
30	that	that	IN	IN	_	33	mark	_	_
31	they	they	PRP	PRP	_	33	nsubj	_	_
32	can	can	MD	MD	_	33	aux	_	_
33	regulate	regulate	VB	VB	_	29	ccomp	_	_
34	induction	induction	NN	NN	_	33	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	apoptosis	apoptosis	NN	NN	_	34	nmod	_	_
37	of	of	IN	IN	_	39	case	_	_
38	endothelial	endothelial	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	and	and	CC	CC	_	39	cc	_	_
41	osteoblasts	osteoblast	NNS	NNS	_	39	conj	_	_
42	.	.	.	.	_	15	punct	_	_

1	TNF-alpha-mediated	tnf-alpha-mediated	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	been	be	VBN	VBN	_	8	auxpass	_	_
7	well	well	RB	RB	_	8	advmod	_	_
8	characterized	characterize	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	myeloid	myeloid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	8	mark	_	_
4	E2	e2	NN	NN	_	8	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Prog	prog	NN	NN	_	4	conj	_	_
7	could	could	MD	MD	_	8	aux	_	_
8	interfere	interfere	VB	VB	_	2	ccomp	_	_
9	with	with	IN	IN	_	11	case	_	_
10	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	monoblastoid	monoblastoid	JJ	JJ	_	17	amod	_	_
15	U937	u937	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	line	line	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Treatment	treatment	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	E2	e2	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	Prog	prog	NN	NN	_	3	conj	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	survival	survival	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	prevented	prevent	VBD	VBD	_	6	conj	_	_
10	apoptosis	apoptosis	NN	NN	_	9	dobj	_	_
11	induced	induce	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	21	case	_	_
15	both	both	CC	CC	_	21	dep	_	_
16	undifferentiated	undifferentiated	JJ	JJ	_	21	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	macrophage-like	macrophage-like	JJ	JJ	_	16	conj	_	_
19	PMA-differentiated	pma-differentiated	JJ	JJ	_	21	amod	_	_
20	U937	u937	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	10	nmod	_	_
22	,	,	,	,	_	9	punct	_	_
23	as	as	IN	IN	_	24	mark	_	_
24	assessed	assess	VBN	VBN	_	9	advcl	_	_
25	by	by	IN	IN	_	24	dep	_	_
26	trypan	trypan	NN	NN	_	30	compound	_	_
27	blue	blue	JJ	JJ	_	30	amod	_	_
28	exclusion	exclusion	NN	NN	_	30	compound	_	_
29	cell	cell	NN	NN	_	30	compound	_	_
30	counting	counting	NN	NN	_	24	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	thymidine	thymidine	NN	NN	_	33	compound	_	_
33	incorporation	incorporation	NN	NN	_	30	appos	_	_
34	,	,	,	,	_	30	punct	_	_
35	AnnexinV	annexinv	NN	NN	_	36	compound	_	_
36	labeling	labeling	NN	NN	_	30	appos	_	_
37	,	,	,	,	_	30	punct	_	_
38	followed	follow	VBN	VBN	_	30	acl	_	_
39	by	by	IN	IN	_	41	case	_	_
40	flow	flow	NN	NN	_	41	compound	_	_
41	cytometry	cytometry	NN	NN	_	38	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	DNA	dna	NN	NN	_	45	compound	_	_
44	fragmentation	fragmentation	NN	NN	_	45	compound	_	_
45	studies	study	NNS	NNS	_	41	conj	_	_
46	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	5	nsubjpass	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	specific	specific	JJ	JJ	_	12	amod	_	_
11	hormone	hormone	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	since	since	IN	IN	_	16	mark	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	observed	observe	VBD	VBD	_	5	advcl	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	estrogen	estrogen	NN	NN	_	23	compound	_	_
22	receptor	receptor	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	ER-alpha	er-alpha	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	23	punct	_	_
28	ER-beta	er-beta	NN	NN	_	23	appos	_	_
29	,	,	,	,	_	23	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	progesterone	progesterone	NN	NN	_	32	compound	_	_
32	receptor	receptor	NN	NN	_	36	compound	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	PR	pr	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	mRNAs	mrna	NNS	NNS	_	23	conj	_	_
37	;	;	:	:	_	5	punct	_	_
38	the	the	DT	DT	_	41	det	_	_
39	ER-alpha	er-alpha	NN	NN	_	41	compound	_	_
40	protein	protein	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	43	nsubjpass	_	_
42	was	be	VBD	VBD	_	43	auxpass	_	_
43	confirmed	confirm	VBN	VBN	_	5	parataxis	_	_
44	by	by	IN	IN	_	46	case	_	_
45	immunocytochemical	immunocytochemical	JJ	JJ	_	46	amod	_	_
46	analysis	analysis	NN	NN	_	43	nmod	_	_
47	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	hormone-mediated	hormone-mediated	JJ	JJ	_	5	amod	_	_
5	survival	survival	NN	NN	_	10	nsubjpass	_	_
6	against	against	IN	IN	_	7	case	_	_
7	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	concentration	concentration	NN	NN	_	10	nmod:npmod	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	reaching	reach	VBG	VBG	_	10	conj	_	_
13	the	the	DT	DT	_	15	det	_	_
14	half-maximal	half-maximal	JJ	JJ	_	15	amod	_	_
15	effect	effect	NN	NN	_	12	dobj	_	_
16	at	at	IN	IN	_	18	case	_	_
17	10	10	CD	CD	_	18	nummod	_	_
18	nM	nm	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	blocked	block	VBN	VBN	_	10	conj	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	ER	er	NN	NN	_	24	compound	_	_
24	antagonist	antagonist	NN	NN	_	20	nmod	_	_
25	ICI	ici	NN	NN	_	24	dep	_	_
26	182	182	CD	CD	_	25	nummod	_	_
27	,	,	,	,	_	25	punct	_	_
28	780	780	CD	CD	_	25	nummod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	undifferentiated	undifferentiated	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	24	nmod	_	_
32	,	,	,	,	_	10	punct	_	_
33	further	further	RB	RB	_	10	advmod	_	_
34	supporting	support	VBG	VBG	_	10	dep	_	_
35	a	a	DT	DT	_	37	det	_	_
36	receptor-mediated	receptor-mediated	JJ	JJ	_	37	amod	_	_
37	mechanism	mechanism	NN	NN	_	34	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	cell	cell	NN	NN	_	40	compound	_	_
40	survival	survival	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	10	punct	_	_

1	Other	other	JJ	JJ	_	4	amod	_	_
2	steroid	steroid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	drugs	drug	NNS	NNS	_	20	nsubj	_	_
5	such	such	JJ	JJ	_	7	case	_	_
6	as	as	IN	IN	_	5	mwe	_	_
7	Raloxifene	raloxifene	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	RU486	ru486	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	or	or	CC	CC	_	7	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ICI	ici	NN	NN	_	7	conj	_	_
14	182	182	CD	CD	_	13	nummod	_	_
15	,	,	,	,	_	13	punct	_	_
16	780	780	CD	CD	_	13	nummod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	PMA-differentiated	pma-differentiated	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	7	nmod	_	_
20	displayed	display	VBD	VBD	_	0	root	_	_
21	agonist	agonist	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	by	by	IN	IN	_	24	mark	_	_
24	preventing	prevent	VBG	VBG	_	20	advcl	_	_
25	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	26	amod	_	_
26	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
27	as	as	RB	RB	_	28	advmod	_	_
28	efficiently	efficiently	RB	RB	_	20	advmod	_	_
29	as	as	IN	IN	_	34	mark	_	_
30	the	the	DT	DT	_	31	det	_	_
31	hormones	hormone	NNS	NNS	_	34	nsubj	_	_
32	alone	alone	RB	RB	_	34	advmod	_	_
33	,	,	,	,	_	34	punct	_	_
34	providing	provide	VBG	VBG	_	28	advcl	_	_
35	further	further	JJ	JJ	_	36	amod	_	_
36	evidence	evidence	NN	NN	_	34	dobj	_	_
37	to	to	TO	TO	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	notion	notion	NN	NN	_	34	nmod	_	_
40	that	that	IN	IN	_	45	mark	_	_
41	steroid	steroid	NN	NN	_	43	compound	_	_
42	receptor	receptor	NN	NN	_	43	compound	_	_
43	drugs	drug	NNS	NNS	_	45	nsubj	_	_
44	may	may	MD	MD	_	45	aux	_	_
45	manifest	manifest	VB	VB	_	39	dep	_	_
46	agonist	agonist	NN	NN	_	45	dobj	_	_
47	or	or	CC	CC	_	34	cc	_	_
48	antagonist	antagonist	NN	NN	_	49	compound	_	_
49	activities	activity	NNS	NNS	_	50	nsubj	_	_
50	depending	depend	VBG	VBG	_	34	conj	_	_
51	on	on	IN	IN	_	54	case	_	_
52	the	the	DT	DT	_	54	det	_	_
53	cellular	cellular	JJ	JJ	_	54	amod	_	_
54	context	context	NN	NN	_	50	nmod	_	_
55	in	in	IN	IN	_	56	case	_	_
56	which	which	WDT	WDT	_	59	nmod	_	_
57	they	they	PRP	PRP	_	59	nsubjpass	_	_
58	are	be	VBP	VBP	_	59	auxpass	_	_
59	studied	study	VBN	VBN	_	54	acl:relcl	_	_
60	.	.	.	.	_	20	punct	_	_

1	Treatment	treatment	NN	NN	_	6	nsubjpass	_	_
2	with	with	IN	IN	_	3	case	_	_
3	E2	e2	NN	NN	_	1	nmod	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	associated	associate	VBN	VBN	_	0	root	_	_
7	with	with	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	time-dependent	time-dependent	JJ	JJ	_	10	amod	_	_
10	decrease	decrease	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	proapoptotic	proapoptotic	JJ	JJ	_	19	amod	_	_
18	Nip-2	nip-2	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	supporting	support	VBG	VBG	_	6	xcomp	_	_
22	the	the	DT	DT	_	23	det	_	_
23	hypothesis	hypothesis	NN	NN	_	21	dobj	_	_
24	that	that	IN	IN	_	31	mark	_	_
25	hormone	hormone	NN	NN	_	26	compound	_	_
26	responsiveness	responsiveness	NN	NN	_	31	nsubjpass	_	_
27	of	of	IN	IN	_	29	case	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	is	be	VBZ	VBZ	_	31	auxpass	_	_
31	mediated	mediate	VBN	VBN	_	23	dep	_	_
32	by	by	IN	IN	_	35	case	_	_
33	target	target	NN	NN	_	35	compound	_	_
34	gene	gene	NN	NN	_	35	compound	_	_
35	transcription	transcription	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	ER	er	NN	NN	_	12	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	PR	pr	NN	NN	_	7	conj	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	5	ccomp	_	_
13	by	by	IN	IN	_	17	case	_	_
14	endogenous	endogenous	JJ	JJ	_	17	amod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	exogenous	exogenous	JJ	JJ	_	14	conj	_	_
17	ligands	ligand	NNS	NNS	_	12	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	induce	induce	VB	VB	_	12	xcomp	_	_
20	a	a	DT	DT	_	22	det	_	_
21	genetic	genetic	JJ	JJ	_	22	amod	_	_
22	response	response	NN	NN	_	19	dobj	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	impairs	impair	VBZ	VBZ	_	22	acl:relcl	_	_
25	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	26	amod	_	_
26	apoptosis	apoptosis	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	U937	u937	NN	NN	_	29	compound	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	presented	present	VBN	VBN	_	2	acl	_	_
4	here	here	RB	RB	_	3	advmod	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	10	det	_	_
8	female	female	JJ	JJ	_	10	amod	_	_
9	steroid	steroid	NN	NN	_	10	compound	_	_
10	receptors	receptor	NNS	NNS	_	11	nsubj	_	_
11	play	play	VBP	VBP	_	5	ccomp	_	_
12	a	a	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	15	case	_	_
15	regulation	regulation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	immune	immune	JJ	JJ	_	19	amod	_	_
19	response	response	NN	NN	_	15	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	preventing	prevent	VBG	VBG	_	11	advcl	_	_
22	apoptosis	apoptosis	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	monoblastoid	monoblastoid	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	;	;	:	:	_	11	punct	_	_
27	this	this	DT	DT	_	28	det	_	_
28	effect	effect	NN	NN	_	30	nsubj	_	_
29	might	might	MD	MD	_	30	aux	_	_
30	have	have	VB	VB	_	11	parataxis	_	_
31	important	important	JJ	JJ	_	32	amod	_	_
32	consequences	consequence	NNS	NNS	_	30	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	the	the	DT	DT	_	36	det	_	_
35	clinical	clinical	JJ	JJ	_	36	amod	_	_
36	use	use	NN	NN	_	32	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	steroid	steroid	NN	NN	_	40	compound	_	_
39	receptor	receptor	NN	NN	_	40	compound	_	_
40	drugs	drug	NNS	NNS	_	36	nmod	_	_
41	.	.	.	.	_	5	punct	_	_

1	--	--	:	:	_	4	punct	_	_
2	Vegeto	Vegeto	NNP	NNP	_	4	compound	_	_
3	,	,	,	,	_	4	punct	_	_
4	E.	E.	NNP	NNP	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	Pollio	Pollio	NNP	NNP	_	8	compound	_	_
7	,	,	,	,	_	8	punct	_	_
8	G.	G.	NNP	NNP	_	4	appos	_	_
9	,	,	,	,	_	4	punct	_	_
10	Pellicciari	Pellicciari	NNP	NNP	_	12	compound	_	_
11	,	,	,	,	_	12	punct	_	_
12	C.	C.	NNP	NNP	_	4	appos	_	_
13	,	,	,	,	_	4	punct	_	_
14	Maggi	Maggi	NNP	NNP	_	16	compound	_	_
15	,	,	,	,	_	16	punct	_	_
16	A	A	NNP	NNP	_	4	appos	_	_
17	.	.	.	.	_	4	punct	_	_

1	Estrogen	estrogen	NN	NN	_	4	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	progesterone	progesterone	NN	NN	_	1	conj	_	_
4	induction	induction	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	survival	survival	NN	NN	_	4	acl	_	_
7	of	of	IN	IN	_	9	case	_	_
8	monoblastoid	monoblastoid	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	undergoing	undergo	VBG	VBG	_	9	acl	_	_
11	TNF-alpha-inuced	tnf-alpha-inuced	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Grf40	grf40	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	A	a	DT	DT	_	7	det	_	_
4	novel	novel	JJ	JJ	_	7	amod	_	_
5	Grb2	grb2	NN	NN	_	7	compound	_	_
6	family	family	NN	NN	_	7	compound	_	_
7	member	member	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	10	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	involved	involve	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	signaling	signaling	NN	NN	_	10	nmod	_	_
15	through	through	IN	IN	_	16	case	_	_
16	interaction	interaction	NN	NN	_	10	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	SLP-76	slp-76	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	LAT	lat	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	molecularly	molecularly	RB	RB	_	3	advmod	_	_
3	cloned	clone	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	new	new	JJ	JJ	_	8	amod	_	_
6	Grb2	grb2	NN	NN	_	8	compound	_	_
7	family	family	NN	NN	_	8	compound	_	_
8	member	member	NN	NN	_	3	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	named	name	VBN	VBN	_	8	acl	_	_
11	Grf40	grf40	NN	NN	_	10	xcomp	_	_
12	,	,	,	,	_	8	punct	_	_
13	containing	contain	VBG	VBG	_	8	acl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	common	common	JJ	JJ	_	17	amod	_	_
16	SH3-SH2-SH3	sh3-sh2-sh3	NN	NN	_	17	compound	_	_
17	motif	motif	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	3	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Grf40	grf40	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	predominant	predominant	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	hematopoietic	hematopoietic	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	particularly	particularly	RB	RB	_	12	advmod	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	8	appos	_	_
13	.	.	.	.	_	5	punct	_	_

1	Grf40	grf40	NN	NN	_	2	nsubj	_	_
2	binds	bind	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	SH2	sh2	NN	NN	_	8	compound	_	_
6	domain-containing	domain-containing	JJ	JJ	_	8	amod	_	_
7	leukocyte	leukocyte	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	76	76	CD	CD	_	11	nummod	_	_
11	kD	kd	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	SLP-76	slp-76	NN	NN	_	8	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	via	via	IN	IN	_	18	case	_	_
16	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
17	SH3	sh3	NN	NN	_	18	compound	_	_
18	domain	domain	NN	NN	_	2	nmod	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	tightly	tightly	RB	RB	_	2	advmod	_	_
21	than	than	IN	IN	_	22	case	_	_
22	Grb2	grb2	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Incidentally	incidentally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Grf40	grf40	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	11	case	_	_
6	linker	linker	NN	NN	_	11	compound	_	_
7	for	for	IN	IN	_	11	amod	_	_
8	activation	activation	NN	NN	_	11	compound	_	_
9	of	of	IN	IN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	LAT	lat	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	possibly	possibly	RB	RB	_	4	advcl	_	_
16	via	via	IN	IN	_	19	case	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	SH2	sh2	NN	NN	_	19	compound	_	_
19	domain	domain	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Overexpression	overexpression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	wild-type	wild-type	JJ	JJ	_	4	amod	_	_
4	Grf40	grf40	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Jurkat	jurkat	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	induced	induce	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	significant	significant	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	19	case	_	_
13	SLP-76-dependent	slp-76-dependent	JJ	JJ	_	19	amod	_	_
14	interleukin	interleukin	NN	NN	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	IL	il	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	-2	-2	CD	CD	_	19	nummod	_	_
19	promoter	promoter	NN	NN	_	11	nmod	_	_
20	and	and	CC	CC	_	11	cc	_	_
21	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
22	factor	factor	NN	NN	_	30	compound	_	_
23	of	of	IN	IN	_	30	amod	_	_
24	activated	activate	VBN	VBN	_	30	amod	_	_
25	T	t	NN	NN	_	30	compound	_	_
26	cell	cell	NN	NN	_	30	compound	_	_
27	(	(	-LRB-	-LRB-	_	30	punct	_	_
28	NF-AT	nf-at	NN	NN	_	30	compound	_	_
29	)	)	-RRB-	-RRB-	_	30	punct	_	_
30	activation	activation	NN	NN	_	11	conj	_	_
31	upon	upon	IN	IN	_	38	case	_	_
32	T	t	NN	NN	_	38	compound	_	_
33	cell	cell	NN	NN	_	38	compound	_	_
34	receptor	receptor	NN	NN	_	38	compound	_	_
35	(	(	-LRB-	-LRB-	_	38	punct	_	_
36	TCR	tcr	NN	NN	_	38	compound	_	_
37	)	)	-RRB-	-RRB-	_	38	punct	_	_
38	stimulation	stimulation	NN	NN	_	30	nmod	_	_
39	,	,	,	,	_	8	punct	_	_
40	whereas	whereas	IN	IN	_	8	dep	_	_
41	the	the	DT	DT	_	45	det	_	_
42	COOH-terminal	cooh-terminal	JJ	JJ	_	45	amod	_	_
43	SH3-deleted	sh3-deleted	JJ	JJ	_	45	amod	_	_
44	Grf40	grf40	NN	NN	_	45	compound	_	_
45	mutant	mutant	NN	NN	_	46	nsubj	_	_
46	lacked	lack	VBD	VBD	_	8	parataxis	_	_
47	any	any	DT	DT	_	49	det	_	_
48	recognizable	recognizable	JJ	JJ	_	49	amod	_	_
49	increase	increase	NN	NN	_	46	dobj	_	_
50	in	in	IN	IN	_	53	case	_	_
51	IL-2	il-2	NN	NN	_	53	compound	_	_
52	promoter	promoter	NN	NN	_	53	compound	_	_
53	activity	activity	NN	NN	_	49	nmod	_	_
54	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	SH2-deleted	sh2-deleted	JJ	JJ	_	5	amod	_	_
5	Grf40	grf40	NN	NN	_	7	nsubj	_	_
6	mutant	mutant	JJ	JJ	_	5	amod	_	_
7	led	lead	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	marked	marked	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	activities	activity	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	effect	effect	NN	NN	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	18	nmod	_	_
21	is	be	VBZ	VBZ	_	23	cop	_	_
22	apparently	apparently	RB	RB	_	23	advmod	_	_
23	stronger	stronger	JJR	JJR	_	7	ccomp	_	_
24	than	than	IN	IN	_	25	case	_	_
25	that	that	DT	DT	_	23	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	the	the	DT	DT	_	30	det	_	_
28	SH2-deleted	sh2-deleted	JJ	JJ	_	30	amod	_	_
29	Grb2	grb2	NN	NN	_	30	compound	_	_
30	mutant	mutant	NN	NN	_	25	nmod	_	_
31	.	.	.	.	_	7	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	Grf40	grf40	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	an	a	DT	DT	_	9	det	_	_
8	adaptor	adaptor	NN	NN	_	9	compound	_	_
9	molecule	molecule	NN	NN	_	3	ccomp	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	TCR-mediated	tcr-mediated	JJ	JJ	_	13	amod	_	_
13	signaling	signaling	NN	NN	_	10	nmod	_	_
14	through	through	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	efficient	efficient	JJ	JJ	_	18	amod	_	_
18	interaction	interaction	NN	NN	_	10	nmod	_	_
19	than	than	IN	IN	_	20	case	_	_
20	Grb2	grb2	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	SLP-76	slp-76	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	LAT	lat	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	transduction	transduction	NN	NN	_	0	root	_	_
3	through	through	IN	IN	_	5	case	_	_
4	interferon-gamma	interferon-gamma	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	2	nmod	_	_
6	on	on	IN	IN	_	8	amod	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	eosinophils	eosinophil	NNS	NNS	_	2	dep	_	_
9	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	reported	report	VBD	VBD	_	0	root	_	_
5	on	on	IN	IN	_	13	case	_	_
6	the	the	DT	DT	_	13	det	_	_
7	constitutive	constitutive	JJ	JJ	_	13	amod	_	_
8	interferon-gamma	interferon-gamma	NN	NN	_	9	compound	_	_
9	receptor	receptor	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IFN-gammaR	ifn-gammar	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	expression	expression	NN	NN	_	4	nmod	_	_
14	on	on	IN	IN	_	15	case	_	_
15	eosinophils	eosinophil	NNS	NNS	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	But	but	CC	CC	_	8	advmod	_	_
2	signal	signal	NN	NN	_	3	compound	_	_
3	transduction	transduction	NN	NN	_	8	nsubj	_	_
4	through	through	IN	IN	_	5	case	_	_
5	IFN-gammaR	ifn-gammar	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	7	amod	_	_
7	eosinophils	eosinophil	NNS	NNS	_	3	dep	_	_
8	remains	remain	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	elucidated	elucidate	VBN	VBN	_	8	xcomp	_	_
12	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	involvement	involvement	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	Jak/Stat	jak/stat	NN	NN	_	12	compound	_	_
12	pathway	pathway	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	signaling	signaling	NN	NN	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	eosinophils	eosinophil	NNS	NNS	_	15	nmod	_	_
18	after	after	IN	IN	_	20	case	_	_
19	IFN-gammaR	ifn-gammar	NN	NN	_	20	compound	_	_
20	conjugation	conjugation	NN	NN	_	8	nmod	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	ligand	ligand	NN	NN	_	24	compound	_	_
24	binding	binding	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	METHODS	method	NNS	NNS	_	7	nsubjpass	_	_
2	:	:	:	:	_	7	punct	_	_
3	Purified	purify	VBN	VBN	_	5	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
5	eosinophils	eosinophil	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	stimulated	stimulate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	7	nmod	_	_
10	at	at	IN	IN	_	13	case	_	_
11	37	37	CD	CD	_	13	nummod	_	_
12	degrees	degree	NNS	NNS	_	13	compound	_	_
13	C	c	NN	NN	_	7	nmod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	1-60	1-60	CD	CD	_	16	nummod	_	_
16	min	min	NN	NN	_	7	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IFN-gammaR	ifn-gammar	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	Jak1	jak1	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	Jak2	jak2	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	Stat1alpha	stat1alpha	NN	NN	_	4	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	immunoblotting	immunoblotting	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	Gel-shift	gel-shift	JJ	JJ	_	2	amod	_	_
2	assay	assay	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	also	also	RB	RB	_	5	advmod	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	show	show	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	formation	formation	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	Stat1alpha-DNA	stat1alpha-dna	NN	NN	_	12	compound	_	_
12	complexes	complex	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	RESULTS	result	NNS	NNS	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	binding	binding	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	eosinophils	eosinophil	NNS	NNS	_	6	nmod	_	_
12	initiated	initiate	VBD	VBD	_	4	ccomp	_	_
13	a	a	DT	DT	_	14	det	_	_
14	series	series	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	events	event	NNS	NNS	_	14	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	resulted	result	VBD	VBD	_	14	acl:relcl	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	rapid	rapid	JJ	JJ	_	23	amod	_	_
22	tyrosine	tyrosine	NN	NN	_	23	compound	_	_
23	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
24	of	of	IN	IN	_	29	case	_	_
25	not	not	RB	RB	_	29	neg	_	_
26	only	only	RB	RB	_	29	advmod	_	_
27	the	the	DT	DT	_	29	det	_	_
28	IFN-gammaRalpha	ifn-gammaralpha	NN	NN	_	29	compound	_	_
29	chain	chain	NN	NN	_	23	nmod	_	_
30	but	but	CC	CC	_	29	cc	_	_
31	also	also	RB	RB	_	29	advmod	_	_
32	Jak1	jak1	NN	NN	_	29	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	Jak2	jak2	NN	NN	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	Stat1alpha	stat1alpha	NN	NN	_	32	conj	_	_
38	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IFN-gamma	ifn-gamma	NN	NN	_	5	nsubj	_	_
5	enhanced	enhance	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	DNA-binding	dna-binding	JJ	JJ	_	8	amod	_	_
8	activity	activity	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Stat1alpha	stat1alpha	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	5	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	5	nsubj	_	_
2	:	:	:	:	_	5	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	8	nsubj	_	_
8	affects	affect	VBZ	VBZ	_	5	ccomp	_	_
9	eosinophils	eosinophil	NNS	NNS	_	8	dobj	_	_
10	through	through	IN	IN	_	13	case	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	utilizes	utilize	VBZ	VBZ	_	8	conj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	Jak/Stat	jak/stat	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	15	dobj	_	_
19	as	as	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	mode	mode	NN	NN	_	15	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	signaling	signaling	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor-kappaB	factor-kappab	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	lipopolysaccharide	lipopolysaccharide	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	mononuclear	mononuclear	JJ	JJ	_	9	amod	_	_
9	leukocytes	leukocyte	NNS	NNS	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	prevented	prevent	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	inhibitors	inhibitor	NNS	NNS	_	11	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	cytosolic	cytosolic	JJ	JJ	_	17	amod	_	_
16	phospholipase	phospholipase	NN	NN	_	17	compound	_	_
17	A2	a2	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	synthesis	synthesis	NN	NN	_	5	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	activity	activity	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	85-kDa	85-kda	JJ	JJ	_	14	amod	_	_
12	cytosolic	cytosolic	JJ	JJ	_	14	amod	_	_
13	phospholipase	phospholipase	NN	NN	_	14	compound	_	_
14	A2	a2	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	enzyme	enzyme	NN	NN	_	3	nsubj	_	_
3	releases	release	VBZ	VBZ	_	0	root	_	_
4	arachidonic	arachidonic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	lyso-phospholipids	lyso-phospholipid	NNS	NNS	_	5	conj	_	_
8	from	from	IN	IN	_	9	case	_	_
9	membranes	membrane	NNS	NNS	_	5	nmod	_	_
10	which	which	WDT	WDT	_	12	nsubjpass	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	metabolized	metabolize	VBN	VBN	_	9	acl:relcl	_	_
13	to	to	TO	TO	_	14	case	_	_
14	eicosanoids	eicosanoid	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	platelet-activating-factor	platelet-activating-factor	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	lipid	lipid	NN	NN	_	3	compound	_	_
3	mediators	mediator	NNS	NNS	_	4	nsubj	_	_
4	increase	increase	VBP	VBP	_	0	root	_	_
5	activity	activity	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	expression	expression	NN	NN	_	5	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	indicating	indicate	VBG	VBG	_	4	xcomp	_	_
15	a	a	DT	DT	_	16	det	_	_
16	function	function	NN	NN	_	14	dobj	_	_
17	for	for	IN	IN	_	20	case	_	_
18	cytosolic	cytosolic	JJ	JJ	_	20	amod	_	_
19	phospholipase	phospholipase	NN	NN	_	20	compound	_	_
20	A2	a2	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	signal	signal	NN	NN	_	23	compound	_	_
23	transduction	transduction	NN	NN	_	16	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inflammation	inflammation	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	previously	previously	RB	RB	_	3	advmod	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	trifluoromethylketone	trifluoromethylketone	NN	NN	_	7	compound	_	_
7	inhibitors	inhibitor	NNS	NNS	_	12	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	cytosolic	cytosolic	JJ	JJ	_	11	amod	_	_
10	phospholipase	phospholipase	NN	NN	_	11	compound	_	_
11	A2	a2	NN	NN	_	7	nmod	_	_
12	suppressed	suppress	VBD	VBD	_	3	ccomp	_	_
13	interleukin-1beta	interleukin-1beta	NN	NN	_	14	compound	_	_
14	protein	protein	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	steady-state	steady-state	JJ	JJ	_	18	amod	_	_
17	mRNA	mrna	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	14	conj	_	_
19	in	in	IN	IN	_	25	case	_	_
20	human	human	JJ	JJ	_	25	amod	_	_
21	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	JJ	JJ	_	25	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	25	amod	_	_
23	blood	blood	NN	NN	_	25	compound	_	_
24	mononuclear	mononuclear	JJ	JJ	_	25	amod	_	_
25	leukocytes	leukocyte	NNS	NNS	_	14	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	subcellular	subcellular	JJ	JJ	_	7	amod	_	_
7	mechanisms	mechanism	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	analyzed	analyze	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	13	nmod	_	_
12	trifluoromethylketones	trifluoromethylketone	NNS	NNS	_	13	nsubj	_	_
13	interfere	interfere	VBP	VBP	_	9	ccomp	_	_
14	with	with	IN	IN	_	16	case	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	they	they	PRP	PRP	_	5	nsubj	_	_
5	reduced	reduce	VBD	VBD	_	2	ccomp	_	_
6	the	the	DT	DT	_	11	det	_	_
7	initial	initial	JJ	JJ	_	11	amod	_	_
8	interleukin-1beta	interleukin-1beta	NN	NN	_	11	compound	_	_
9	mRNA	mrna	NN	NN	_	11	compound	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	rate	rate	NN	NN	_	5	dobj	_	_
12	through	through	IN	IN	_	13	case	_	_
13	prevention	prevention	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	degradation	degradation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	inhibitor-kappaB	inhibitor-kappab	NN	NN	_	18	compound	_	_
18	alpha	alpha	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Consequently	consequently	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	cytosolic	cytosolic	JJ	JJ	_	4	amod	_	_
4	activation	activation	NN	NN	_	14	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	4	conj	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	DNA-binding	dna-binding	NN	NN	_	4	conj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	factor-kappaB	factor-kappab	NN	NN	_	4	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	decreased	decrease	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	Trifluoromethylketones	trifluoromethylketone	NNS	NNS	_	2	nsubj	_	_
2	ameliorate	ameliorate	VBP	VBP	_	0	root	_	_
3	chronic	chronic	JJ	JJ	_	4	amod	_	_
4	inflammation	inflammation	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	vivo	vivo	FW	FW	_	2	advmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	this	this	DT	DT	_	5	det	_	_
4	therapeutic	therapeutic	JJ	JJ	_	5	amod	_	_
5	potency	potency	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	reside	reside	VB	VB	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	retention	retention	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	inactive	inactive	JJ	JJ	_	13	amod	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor-kappaB	factor-kappab	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cytosol	cytosol	NN	NN	_	13	nmod	_	_
17	thereby	thereby	RB	RB	_	7	advmod	_	_
18	abrogating	abrogate	VBG	VBG	_	7	xcomp	_	_
19	interleukin-1beta	interleukin-1beta	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	transcription	transcription	NN	NN	_	18	dobj	_	_
22	.	.	.	.	_	7	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	7	case	_	_
4	an	a	DT	DT	_	7	det	_	_
5	epithelial	epithelial	JJ	JJ	_	7	amod	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transducer	transducer	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	activator	activator	NN	NN	_	2	conj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	transcription	transcription	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	STAT	stat	NN	NN	_	15	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	pathway	pathway	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	asthma	asthma	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	effects	effect	NNS	NNS	_	8	nsubj	_	_
3	on	on	IN	IN	_	4	case	_	_
4	immunity	immunity	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	inflammation	inflammation	NN	NN	_	4	conj	_	_
7	often	often	RB	RB	_	8	advmod	_	_
8	depend	depend	VBP	VBP	_	0	root	_	_
9	on	on	IN	IN	_	12	amod	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	8	dobj	_	_
13	termed	term	VBN	VBN	_	12	acl	_	_
14	signal	signal	NN	NN	_	15	compound	_	_
15	transducers	transducer	NNS	NNS	_	13	xcomp	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	activators	activator	NNS	NNS	_	19	compound	_	_
18	of	of	IN	IN	_	19	amod	_	_
19	transcription	transcription	NN	NN	_	15	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	STATs	stats	NNS	NNS	_	15	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	8	punct	_	_
24	so	so	RB	RB	_	8	advmod	_	_
25	STAT	stat	NN	NN	_	27	compound	_	_
26	signaling	signaling	NN	NN	_	27	compound	_	_
27	pathways	pathway	NNS	NNS	_	29	nsubj	_	_
28	are	be	VBP	VBP	_	29	cop	_	_
29	candidates	candidate	NNS	NNS	_	8	parataxis	_	_
30	for	for	IN	IN	_	31	mark	_	_
31	influencing	influence	VBG	VBG	_	29	acl	_	_
32	inflammatory	inflammatory	JJ	JJ	_	33	amod	_	_
33	disease	disease	NN	NN	_	31	dobj	_	_
34	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	reasoned	reason	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	43	mark	_	_
4	selective	selective	JJ	JJ	_	6	amod	_	_
5	IFN	ifn	NN	NN	_	6	compound	_	_
6	responsiveness	responsiveness	NN	NN	_	43	nsubj	_	_
7	of	of	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	first	first	JJ	JJ	_	12	amod	_	_
10	STAT	stat	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	member	member	NN	NN	_	6	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	Stat1	stat1	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	Stat1-dependent	stat1-dependent	JJ	JJ	_	19	amod	_	_
18	immune-response	immune-response	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	12	conj	_	_
20	such	such	JJ	JJ	_	24	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	intercellular	intercellular	JJ	JJ	_	24	amod	_	_
23	adhesion	adhesion	NN	NN	_	24	compound	_	_
24	molecule-1	molecule-1	NN	NN	_	19	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	ICAM-1	icam-1	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	24	punct	_	_
29	IFN	ifn	NN	NN	_	31	compound	_	_
30	regulatory	regulatory	JJ	JJ	_	31	amod	_	_
31	factor-1	factor-1	NN	NN	_	24	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	IRF-1	irf-1	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	24	punct	_	_
36	and	and	CC	CC	_	24	cc	_	_
37	Stat1	stat1	NN	NN	_	24	conj	_	_
38	itself	itself	PRP	PRP	_	37	nmod:npmod	_	_
39	in	in	IN	IN	_	42	case	_	_
40	airway	airway	NN	NN	_	42	compound	_	_
41	epithelial	epithelial	JJ	JJ	_	42	amod	_	_
42	cells	cell	NNS	NNS	_	37	nmod	_	_
43	provides	provide	VBZ	VBZ	_	2	ccomp	_	_
44	a	a	DT	DT	_	45	det	_	_
45	basis	basis	NN	NN	_	43	dobj	_	_
46	for	for	IN	IN	_	47	mark	_	_
47	detecting	detect	VBG	VBG	_	45	acl	_	_
48	cytokine	cytokine	NN	NN	_	50	compound	_	_
49	signaling	signaling	NN	NN	_	50	compound	_	_
50	abnormalities	abnormality	NNS	NNS	_	47	dobj	_	_
51	in	in	IN	IN	_	54	case	_	_
52	inflammatory	inflammatory	JJ	JJ	_	54	amod	_	_
53	airway	airway	NN	NN	_	54	compound	_	_
54	disease	disease	NN	NN	_	47	nmod	_	_
55	.	.	.	.	_	2	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	basis	basis	NN	NN	_	11	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	localization	localization	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	found	find	VBD	VBD	_	0	root	_	_
12	that	that	IN	IN	_	25	mark	_	_
13	epithelial	epithelial	JJ	JJ	_	14	amod	_	_
14	Stat1	stat1	NN	NN	_	25	nsubjpass	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	but	but	CC	CC	_	21	cc	_	_
17	not	not	RB	RB	_	21	dep	_	_
18	other	other	JJ	JJ	_	21	amod	_	_
19	control	control	NN	NN	_	21	compound	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	14	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	was	be	VBD	VBD	_	25	auxpass	_	_
24	invariably	invariably	RB	RB	_	25	advmod	_	_
25	activated	activate	VBN	VBN	_	11	ccomp	_	_
26	in	in	IN	IN	_	27	case	_	_
27	asthmatic	asthmatic	JJ	JJ	_	25	nmod	_	_
28	compared	compare	VBN	VBN	_	25	dep	_	_
29	with	with	IN	IN	_	31	case	_	_
30	normal	normal	JJ	JJ	_	31	amod	_	_
31	control	control	JJ	JJ	_	28	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	chronic	chronic	JJ	JJ	_	35	amod	_	_
34	bronchitis	bronchitis	NN	NN	_	35	compound	_	_
35	subjects	subject	NNS	NNS	_	31	conj	_	_
36	.	.	.	.	_	11	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	epithelial	epithelial	JJ	JJ	_	4	amod	_	_
4	levels	level	NNS	NNS	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	activated	activate	VBN	VBN	_	7	amod	_	_
7	Stat1	stat1	NN	NN	_	4	nmod	_	_
8	correlated	correlate	VBD	VBD	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	levels	level	NNS	NNS	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	epithelial	epithelial	JJ	JJ	_	15	amod	_	_
15	ICAM-1	icam-1	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	IRF-1	irf-1	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	Stat1	stat1	NN	NN	_	15	conj	_	_
21	,	,	,	,	_	8	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	in	in	IN	IN	_	24	case	_	_
24	turn	turn	NN	NN	_	28	nmod	_	_
25	,	,	,	,	_	28	punct	_	_
26	ICAM-1	icam-1	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	28	nsubj	_	_
28	correlated	correlate	VBD	VBD	_	8	conj	_	_
29	with	with	IN	IN	_	31	case	_	_
30	T-cell	t-cell	NN	NN	_	31	compound	_	_
31	accumulation	accumulation	NN	NN	_	28	nmod	_	_
32	in	in	IN	IN	_	33	case	_	_
33	tissue	tissue	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	only	only	RB	RB	_	5	advmod	_	_
4	low	low	JJ	JJ	_	5	amod	_	_
5	levels	level	NNS	NNS	_	12	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	IFN-gamma-producing	ifn-gamma-producing	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	conj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	airway	airway	NN	NN	_	15	compound	_	_
15	tissue	tissue	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	all	all	DT	DT	_	18	det	_	_
18	subjects	subject	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	therefore	therefore	RB	RB	_	4	advmod	_	_
4	provide	provide	VBP	VBP	_	0	root	_	_
5	initial	initial	JJ	JJ	_	6	amod	_	_
6	evidence	evidence	NN	NN	_	4	dobj	_	_
7	linking	link	VBG	VBG	_	6	acl	_	_
8	abnormal	abnormal	JJ	JJ	_	9	amod	_	_
9	behavior	behavior	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	STAT	stat	NN	NN	_	12	compound	_	_
12	pathways	pathway	NNS	NNS	_	9	nmod	_	_
13	for	for	IN	IN	_	15	case	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	signaling	signaling	NN	NN	_	9	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	development	development	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	inflammatory	inflammatory	JJ	JJ	_	22	amod	_	_
22	disease	disease	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	that	that	DT	DT	_	3	det	_	_
3	context	context	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	results	result	NNS	NNS	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	change	change	VBP	VBP	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	current	current	JJ	JJ	_	11	amod	_	_
11	scheme	scheme	NN	NN	_	8	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	asthma	asthma	NN	NN	_	14	compound	_	_
14	pathogenesis	pathogenesis	NN	NN	_	11	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	one	one	CD	CD	_	8	nmod	_	_
17	that	that	WDT	WDT	_	19	nsubj	_	_
18	must	must	MD	MD	_	19	aux	_	_
19	include	include	VB	VB	_	16	acl:relcl	_	_
20	a	a	DT	DT	_	22	det	_	_
21	localized	localized	JJ	JJ	_	22	amod	_	_
22	gain	gain	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	transcriptional	transcriptional	JJ	JJ	_	25	amod	_	_
25	signal	signal	NN	NN	_	22	nmod	_	_
26	ordinarily	ordinarily	RB	RB	_	27	advmod	_	_
27	used	use	VBN	VBN	_	25	dep	_	_
28	for	for	IN	IN	_	33	case	_	_
29	a	a	DT	DT	_	33	det	_	_
30	T	t	NN	NN	_	33	compound	_	_
31	helper	helper	NN	NN	_	33	compound	_	_
32	1-type	1-type	JJ	JJ	_	33	amod	_	_
33	cytokine	cytokine	NN	NN	_	27	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	IFN-gamma	ifn-gamma	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	in	in	IN	IN	_	38	case	_	_
38	combination	combination	NN	NN	_	27	nmod	_	_
39	with	with	IN	IN	_	41	case	_	_
40	allergy-driven	allergy-driven	JJ	JJ	_	41	amod	_	_
41	overproduction	overproduction	NN	NN	_	38	nmod	_	_
42	of	of	IN	IN	_	46	case	_	_
43	T	t	NN	NN	_	46	compound	_	_
44	helper	helper	NN	NN	_	46	compound	_	_
45	2-type	2-type	JJ	JJ	_	46	amod	_	_
46	cytokines	cytokine	NNS	NNS	_	41	nmod	_	_
47	.	.	.	.	_	8	punct	_	_

1	Molecular	molecular	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	cytokine	cytokine	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	2	nmod	_	_
7	during	during	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	by	by	IN	IN	_	6	case	_	_
4	immune	immune	JJ	JJ	_	6	amod	_	_
5	system	system	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	plays	play	VBZ	VBZ	_	0	root	_	_
8	an	a	DT	DT	_	10	det	_	_
9	important	important	JJ	JJ	_	10	amod	_	_
10	role	role	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	immune	immune	JJ	JJ	_	17	amod	_	_
17	response	response	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	first	first	JJ	JJ	_	3	amod	_	_
3	encounter	encounter	NN	NN	_	15	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	antigen	antigen	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	15	punct	_	_
7	naive	naive	JJ	JJ	_	14	amod	_	_
8	CD4+	cd4+	JJ	JJ	_	14	amod	_	_
9	T	t	NN	NN	_	14	compound	_	_
10	helper	helper	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	Th	th	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	cells	cell	NNS	NNS	_	15	nsubj	_	_
15	differentiate	differentiate	VBP	VBP	_	0	root	_	_
16	into	into	IN	IN	_	19	case	_	_
17	cytokine-producing	cytokine-producing	JJ	JJ	_	19	amod	_	_
18	effector	effector	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	Two	two	CD	CD	_	2	nummod	_	_
2	types	type	NNS	NNS	_	16	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	effector	effector	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	characterized	characterize	VBN	VBN	_	2	acl	_	_
7	by	by	IN	IN	_	10	case	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	distinct	distinct	JJ	JJ	_	10	amod	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	profiles	profile	NNS	NNS	_	10	nmod	_	_
14	have	have	VBP	VBP	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	described	describe	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Th1	th1	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	produce	produce	VBP	VBP	_	0	root	_	_
4	IL-2	il-2	NN	NN	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IFN-gamma	ifn-gamma	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	3	punct	_	_
8	whereas	whereas	IN	IN	_	3	dep	_	_
9	Th2	th2	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	11	nsubj	_	_
11	produce	produce	VBP	VBP	_	3	parataxis	_	_
12	IL-4	il-4	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	IL-5	il-5	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	IL-6	il-6	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	IL-10	il-10	NN	NN	_	12	conj	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	IL-13	il-13	NN	NN	_	12	conj	_	_
22	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	many	many	JJ	JJ	_	4	amod	_	_
3	pathological	pathological	JJ	JJ	_	4	amod	_	_
4	situations	situation	NNS	NNS	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	balance	balance	NN	NN	_	14	nsubj	_	_
8	between	between	IN	IN	_	9	case	_	_
9	Th1	th1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Th2	th2	NN	NN	_	9	conj	_	_
12	immune	immune	JJ	JJ	_	13	amod	_	_
13	responses	response	NNS	NNS	_	9	dep	_	_
14	determines	determine	VBZ	VBZ	_	0	root	_	_
15	the	the	DT	DT	_	16	det	_	_
16	outcome	outcome	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	diverse	diverse	JJ	JJ	_	22	amod	_	_
19	immunologically	immunologically	RB	RB	_	22	advmod	_	_
20	mediated	mediate	VBN	VBN	_	22	amod	_	_
21	clinical	clinical	JJ	JJ	_	22	amod	_	_
22	syndromes	syndrome	NNS	NNS	_	16	nmod	_	_
23	including	include	VBG	VBG	_	24	case	_	_
24	infectious	infectious	JJ	JJ	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	autoimmune	autoimmune	JJ	JJ	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	allergic	allergic	JJ	JJ	_	24	conj	_	_
30	diseases	disease	NNS	NNS	_	24	dep	_	_
31	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	14	nsubj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	tissue-specific	tissue-specific	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	Th1/Th2-like	th1/th2-like	JJ	JJ	_	12	amod	_	_
12	cytokines	cytokine	NNS	NNS	_	9	nmod	_	_
13	has	have	VBZ	VBZ	_	14	aux	_	_
14	remained	remain	VBN	VBN	_	0	root	_	_
15	elusive	elusive	JJ	JJ	_	14	xcomp	_	_
16	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	evaluate	evaluate	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	10	det	_	_
7	possible	possible	JJ	JJ	_	10	amod	_	_
8	in	in	FW	FW	_	10	compound	_	_
9	vivo	vivo	FW	FW	_	10	compound	_	_
10	role	role	NN	NN	_	5	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	different	different	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	mechanisms	mechanism	NNS	NNS	_	14	conj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	14	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	25	det	_	_
24	immune	immune	JJ	JJ	_	25	amod	_	_
25	response	response	NN	NN	_	21	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	evolutionarily	evolutionarily	RB	RB	_	4	advmod	_	_
3	conserved	conserve	VBN	VBN	_	4	amod	_	_
4	sequence	sequence	NN	NN	_	19	nsubj	_	_
5	upstream	upstream	RB	RB	_	4	advmod	_	_
6	of	of	IN	IN	_	15	case	_	_
7	the	the	DT	DT	_	15	det	_	_
8	human	human	JJ	JJ	_	15	amod	_	_
9	Ig	ig	NN	NN	_	15	compound	_	_
10	heavy	heavy	JJ	JJ	_	15	amod	_	_
11	chain	chain	NN	NN	_	15	compound	_	_
12	S	s	NN	NN	_	15	compound	_	_
13	gamma	gamma	NN	NN	_	15	compound	_	_
14	3	3	CD	CD	_	15	nummod	_	_
15	region	region	NN	NN	_	4	nmod	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	an	a	DT	DT	_	19	det	_	_
18	inducible	inducible	JJ	JJ	_	19	amod	_	_
19	promoter	promoter	NN	NN	_	0	root	_	_
20	:	:	:	:	_	19	punct	_	_
21	synergistic	synergistic	JJ	JJ	_	22	amod	_	_
22	activation	activation	NN	NN	_	19	dep	_	_
23	by	by	IN	IN	_	25	case	_	_
24	CD40	cd40	NN	NN	_	25	compound	_	_
25	ligand	ligand	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	IL-4	il-4	NN	NN	_	25	conj	_	_
28	via	via	IN	IN	_	31	case	_	_
29	cooperative	cooperative	JJ	JJ	_	31	amod	_	_
30	NF-kappa	nf-kappa	NN	NN	_	31	compound	_	_
31	B	b	NN	NN	_	22	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	STAT-6	stat-6	NN	NN	_	31	conj	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	sites	site	NNS	NNS	_	31	dep	_	_
36	.	.	.	.	_	19	punct	_	_

1	Germline	germline	NN	NN	_	5	compound	_	_
2	C	c	NN	NN	_	5	compound	_	_
3	gamma	gamma	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	transcription	transcription	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	crucial	crucial	JJ	JJ	_	9	amod	_	_
9	event	event	NN	NN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	process	process	NN	NN	_	9	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	leads	lead	VBZ	VBZ	_	12	acl:relcl	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	switch	switch	VB	VB	_	14	xcomp	_	_
17	DNA	dna	NN	NN	_	18	compound	_	_
18	recombination	recombination	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	IgG	igg	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	but	but	CC	CC	_	9	cc	_	_
23	its	its	PRP$	PRP$	_	24	nmod:poss	_	_
24	regulation	regulation	NN	NN	_	30	nsubjpass	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	human	human	JJ	JJ	_	24	nmod	_	_
28	is	be	VBZ	VBZ	_	30	auxpass	_	_
29	poorly	poorly	RB	RB	_	30	advmod	_	_
30	understood	understand	VBN	VBN	_	9	conj	_	_
31	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	took	take	VBD	VBD	_	0	root	_	_
3	advantage	advantage	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
6	monoclonal	monoclonal	JJ	JJ	_	7	amod	_	_
7	model	model	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	13	case	_	_
9	germinal	germinal	JJ	JJ	_	13	amod	_	_
10	center	center	NN	NN	_	13	compound	_	_
11	B	b	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	differentiation	differentiation	NN	NN	_	7	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	IgM+	igm+	JJ	JJ	_	18	amod	_	_
16	IgD+	igd+	JJ	JJ	_	18	amod	_	_
17	CL-01	cl-01	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	appos	_	_
19	,	,	,	,	_	3	punct	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	define	define	VB	VB	_	3	acl	_	_
22	the	the	DT	DT	_	23	det	_	_
23	role	role	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	31	case	_	_
25	the	the	DT	DT	_	31	det	_	_
26	I	i	NN	NN	_	31	compound	_	_
27	gamma	gamma	NN	NN	_	31	compound	_	_
28	3	3	CD	CD	_	31	nummod	_	_
29	evolutionarily	evolutionarily	RB	RB	_	31	advmod	_	_
30	conserved	conserve	VBN	VBN	_	31	amod	_	_
31	sequence	sequence	NN	NN	_	23	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ECS	ecs	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	in	in	IN	IN	_	39	case	_	_
36	the	the	DT	DT	_	39	det	_	_
37	germline	germline	NN	NN	_	39	compound	_	_
38	transcriptional	transcriptional	JJ	JJ	_	39	amod	_	_
39	activation	activation	NN	NN	_	23	nmod	_	_
40	of	of	IN	IN	_	46	case	_	_
41	the	the	DT	DT	_	46	det	_	_
42	human	human	JJ	JJ	_	46	amod	_	_
43	C	c	NN	NN	_	46	compound	_	_
44	gamma	gamma	NN	NN	_	46	compound	_	_
45	3	3	CD	CD	_	46	nummod	_	_
46	gene	gene	NN	NN	_	39	nmod	_	_
47	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	I	i	NN	NN	_	3	compound	_	_
3	gamma	gamma	NN	NN	_	6	nsubj	_	_
4	3	3	CD	CD	_	3	nummod	_	_
5	ECS	ecs	NN	NN	_	3	dep	_	_
6	lies	lie	VBZ	VBZ	_	0	root	_	_
7	upstream	upstream	RB	RB	_	6	advmod	_	_
8	of	of	IN	IN	_	16	case	_	_
9	the	the	DT	DT	_	16	det	_	_
10	major	major	JJ	JJ	_	16	amod	_	_
11	I	i	NN	NN	_	16	compound	_	_
12	gamma	gamma	NN	NN	_	16	compound	_	_
13	3	3	CD	CD	_	16	nummod	_	_
14	transcription	transcription	NN	NN	_	16	compound	_	_
15	initiation	initiation	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	7	nmod	_	_
17	and	and	CC	CC	_	6	cc	_	_
18	displays	display	VBZ	VBZ	_	6	conj	_	_
19	more	more	JJR	JJR	_	22	advmod	_	_
20	than	than	IN	IN	_	19	mwe	_	_
21	90	90	CD	CD	_	22	compound	_	_
22	%	%	NN	NN	_	23	nummod	_	_
23	identity	identity	NN	NN	_	18	dobj	_	_
24	with	with	IN	IN	_	40	case	_	_
25	the	the	DT	DT	_	40	det	_	_
26	corresponding	corresponding	JJ	JJ	_	40	amod	_	_
27	human	human	JJ	JJ	_	29	amod	_	_
28	I	i	NN	NN	_	29	compound	_	_
29	gamma	gamma	NN	NN	_	40	compound	_	_
30	1	1	CD	CD	_	29	nummod	_	_
31	,	,	,	,	_	29	punct	_	_
32	I	i	NN	NN	_	33	compound	_	_
33	gamma	gamma	NN	NN	_	29	conj	_	_
34	2	2	CD	CD	_	33	nummod	_	_
35	,	,	,	,	_	29	punct	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	I	i	NN	NN	_	38	compound	_	_
38	gamma	gamma	NN	NN	_	29	conj	_	_
39	4	4	CD	CD	_	38	nummod	_	_
40	regions	region	NNS	NNS	_	23	nmod	_	_
41	.	.	.	.	_	6	punct	_	_

1	Reporter	reporter	NN	NN	_	4	compound	_	_
2	luciferase	luciferase	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	vectors	vector	NNS	NNS	_	12	nsubjpass	_	_
5	containing	contain	VBG	VBG	_	4	dep	_	_
6	the	the	DT	DT	_	10	det	_	_
7	human	human	JJ	JJ	_	10	amod	_	_
8	gamma	gamma	NN	NN	_	10	compound	_	_
9	3	3	CD	CD	_	10	nummod	_	_
10	ECS	ecs	NN	NN	_	5	dobj	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	transfect	transfect	VB	VB	_	12	xcomp	_	_
15	CL-01	cl-01	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	14	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	21	nsubjpass	_	_
19	have	have	VBP	VBP	_	21	aux	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	shown	show	VBN	VBN	_	16	acl:relcl	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	undergo	undergo	VB	VB	_	21	xcomp	_	_
24	Smu	smu	NN	NN	_	30	compound	_	_
25	--&gt;	--&gt;	TO	TO	_	30	dep	_	_
26	S	s	NN	NN	_	30	compound	_	_
27	gamma	gamma	NN	NN	_	30	compound	_	_
28	3	3	CD	CD	_	30	nummod	_	_
29	DNA	dna	NN	NN	_	30	compound	_	_
30	recombination	recombination	NN	NN	_	23	dobj	_	_
31	,	,	,	,	_	23	punct	_	_
32	upon	upon	IN	IN	_	33	case	_	_
33	engagement	engagement	NN	NN	_	23	nmod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	CD40	cd40	NN	NN	_	33	nmod	_	_
36	by	by	IN	IN	_	38	case	_	_
37	CD40	cd40	NN	NN	_	38	compound	_	_
38	ligand	ligand	NN	NN	_	33	nmod	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	CD40L	cd40l	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	and	and	CC	CC	_	38	cc	_	_
43	exposure	exposure	NN	NN	_	38	conj	_	_
44	to	to	TO	TO	_	45	case	_	_
45	IL-4	il-4	NN	NN	_	43	nmod	_	_
46	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	these	these	DT	DT	_	5	det	_	_
3	transfected	transfect	VBN	VBN	_	5	amod	_	_
4	CL-01	cl-01	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	14	nmod	_	_
6	,	,	,	,	_	14	punct	_	_
7	CD40:CD40L	cd40:cd40l	NN	NN	_	8	compound	_	_
8	engagement	engagement	NN	NN	_	14	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	exposure	exposure	NN	NN	_	8	conj	_	_
11	to	to	TO	TO	_	12	case	_	_
12	IL-4	il-4	NN	NN	_	10	nmod	_	_
13	synergistically	synergistically	RB	RB	_	14	advmod	_	_
14	induced	induce	VBD	VBD	_	0	root	_	_
15	gamma	gamma	NN	NN	_	21	compound	_	_
16	3	3	CD	CD	_	21	nummod	_	_
17	ECS-dependent	ecs-dependent	JJ	JJ	_	21	amod	_	_
18	luciferase	luciferase	NN	NN	_	21	compound	_	_
19	reporter	reporter	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	14	dobj	_	_
22	.	.	.	.	_	14	punct	_	_

1	Targeted	target	VBN	VBN	_	3	amod	_	_
2	mutational	mutational	JJ	JJ	_	3	amod	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	a	a	DT	DT	_	11	det	_	_
7	tandem	tandem	JJ	JJ	_	11	amod	_	_
8	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
9	B/Rel	b/rel	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	motif	motif	NN	NN	_	13	nsubj	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	critical	critical	JJ	JJ	_	4	ccomp	_	_
14	for	for	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	gamma	gamma	NN	NN	_	19	compound	_	_
17	3	3	CD	CD	_	19	nummod	_	_
18	ECS	ecs	NN	NN	_	19	compound	_	_
19	responsiveness	responsiveness	NN	NN	_	13	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	both	both	CC	CC	_	22	cc:preconj	_	_
22	CD40L	cd40l	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-4	il-4	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	13	punct	_	_
26	while	while	IN	IN	_	32	mark	_	_
27	a	a	DT	DT	_	29	det	_	_
28	STAT-6-binding	stat-6-binding	JJ	JJ	_	29	amod	_	_
29	site	site	NN	NN	_	32	nsubjpass	_	_
30	is	be	VBZ	VBZ	_	32	auxpass	_	_
31	additionally	additionally	RB	RB	_	32	advmod	_	_
32	required	require	VBN	VBN	_	13	advcl	_	_
33	for	for	IN	IN	_	35	case	_	_
34	IL-4	il-4	NN	NN	_	35	compound	_	_
35	inducibility	inducibility	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	4	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	p50/p65/c-Rel	p50/p65/c-rel	NN	NN	_	12	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	STAT-6	stat-6	NN	NN	_	7	conj	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	effectively	effectively	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	5	ccomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	CD40L	cd40l	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IL-4	il-4	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	respectively	respectively	RB	RB	_	12	advmod	_	_
19	,	,	,	,	_	12	punct	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	bind	bind	VBP	VBP	_	12	conj	_	_
22	to	to	TO	TO	_	25	case	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	DNA	dna	NN	NN	_	25	compound	_	_
25	motifs	motif	NNS	NNS	_	21	nmod	_	_
26	within	within	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	ECS	ecs	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	4	det	_	_
2	partially	partially	RB	RB	_	3	advmod	_	_
3	overlapping	overlap	VBG	VBG	_	4	amod	_	_
4	CD40L	cd40l	NN	NN	_	11	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	IL-4	il-4	NN	NN	_	4	conj	_	_
7	responsive	responsive	JJ	JJ	_	8	amod	_	_
8	elements	element	NNS	NNS	_	4	dep	_	_
9	are	be	VBP	VBP	_	11	cop	_	_
10	functionally	functionally	RB	RB	_	11	advmod	_	_
11	cooperative	cooperative	JJ	JJ	_	0	root	_	_
12	as	as	IN	IN	_	19	mark	_	_
13	the	the	DT	DT	_	14	det	_	_
14	disruption	disruption	NN	NN	_	19	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	one	one	CD	CD	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	them	they	PRP	PRP	_	16	nmod	_	_
19	prevents	prevent	VBZ	VBZ	_	11	advcl	_	_
20	synergistic	synergistic	JJ	JJ	_	22	amod	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	activation	activation	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	gamma	gamma	NN	NN	_	6	compound	_	_
5	3	3	CD	CD	_	6	nummod	_	_
6	ECS	ecs	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	an	a	DT	DT	_	10	det	_	_
9	inducible	inducible	JJ	JJ	_	10	amod	_	_
10	promoter	promoter	NN	NN	_	0	root	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	cis	cis	NN	NN	_	13	compound	_	_
13	elements	element	NNS	NNS	_	11	dobj	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	critically	critically	RB	RB	_	16	advmod	_	_
16	mediate	mediate	VBP	VBP	_	13	acl:relcl	_	_
17	CD40L	cd40l	NN	NN	_	16	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-4-triggered	il-4-triggered	JJ	JJ	_	21	amod	_	_
20	transcriptional	transcriptional	JJ	JJ	_	21	amod	_	_
21	activation	activation	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	28	case	_	_
23	the	the	DT	DT	_	28	det	_	_
24	human	human	JJ	JJ	_	28	amod	_	_
25	C	c	NN	NN	_	28	compound	_	_
26	gamma	gamma	NN	NN	_	28	compound	_	_
27	3	3	CD	CD	_	28	nummod	_	_
28	gene	gene	NN	NN	_	17	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	HLA	hla	NN	NN	_	4	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	I-mediated	i-mediated	JJ	JJ	_	4	amod	_	_
4	induction	induction	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	proliferation	proliferation	NN	NN	_	4	nmod	_	_
8	involves	involve	VBZ	VBZ	_	0	root	_	_
9	cyclin	cyclin	NN	NN	_	11	compound	_	_
10	E-mediated	e-mediated	JJ	JJ	_	11	amod	_	_
11	inactivation	inactivation	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Rb	rb	NN	NN	_	14	compound	_	_
14	function	function	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	induction	induction	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	E2F	e2f	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Chronic	chronic	JJ	JJ	_	2	amod	_	_
2	rejection	rejection	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transplanted	transplant	VBN	VBN	_	5	amod	_	_
5	organs	organ	NNS	NNS	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	manifested	manifest	VBN	VBN	_	0	root	_	_
8	as	as	IN	IN	_	9	case	_	_
9	atherosclerosis	atherosclerosis	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	blood	blood	NN	NN	_	13	compound	_	_
13	vessels	vessel	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	allograft	allograft	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	HLA	hla	NN	NN	_	4	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	I	i	CD	CD	_	4	nummod	_	_
4	Ags	ag	NNS	NNS	_	7	nsubjpass	_	_
5	have	have	VBP	VBP	_	7	dep	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	implicated	implicate	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	play	play	VB	VB	_	7	xcomp	_	_
10	a	a	DT	DT	_	12	det	_	_
11	major	major	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	this	this	DT	DT	_	15	det	_	_
15	process	process	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	7	punct	_	_
17	since	since	IN	IN	_	25	mark	_	_
18	signaling	signal	VBG	VBG	_	25	nsubj	_	_
19	via	via	IN	IN	_	23	case	_	_
20	HLA	hla	NN	NN	_	23	compound	_	_
21	class	class	NN	NN	_	23	compound	_	_
22	I	i	CD	CD	_	23	nummod	_	_
23	molecules	molecule	NNS	NNS	_	18	nmod	_	_
24	can	can	MD	MD	_	25	aux	_	_
25	induce	induce	VB	VB	_	7	advcl	_	_
26	the	the	DT	DT	_	27	det	_	_
27	proliferation	proliferation	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	aortic	aortic	JJ	JJ	_	30	amod	_	_
30	endothelial	endothelial	NN	NN	_	27	nmod	_	_
31	as	as	RB	RB	_	30	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	smooth	smooth	JJ	JJ	_	36	amod	_	_
35	muscle	muscle	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	30	conj	_	_
37	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	15	mark	_	_
8	HLA	hla	NN	NN	_	11	compound	_	_
9	class	class	NN	NN	_	11	compound	_	_
10	I-mediated	i-mediated	JJ	JJ	_	11	amod	_	_
11	induction	induction	NN	NN	_	15	nsubj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	proliferation	proliferation	NN	NN	_	11	nmod	_	_
15	correlates	correlate	VBZ	VBZ	_	6	ccomp	_	_
16	with	with	IN	IN	_	17	case	_	_
17	inactivation	inactivation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Rb	rb	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	17	nmod	_	_
22	in	in	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	T	t	NN	NN	_	27	compound	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	line	line	NN	NN	_	27	compound	_	_
27	Jurkat	jurkat	NN	NN	_	21	nmod	_	_
28	as	as	RB	RB	_	27	cc	_	_
29	well	well	RB	RB	_	28	mwe	_	_
30	as	as	IN	IN	_	28	mwe	_	_
31	human	human	JJ	JJ	_	34	amod	_	_
32	aortic	aortic	JJ	JJ	_	34	amod	_	_
33	endothelial	endothelial	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	27	conj	_	_
35	.	.	.	.	_	6	punct	_	_

1	HLA	hla	NN	NN	_	4	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	I-mediated	i-mediated	JJ	JJ	_	4	amod	_	_
4	inactivation	inactivation	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Rb	rb	NN	NN	_	4	nmod	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	auxpass	_	_
9	inhibited	inhibit	VBN	VBN	_	0	root	_	_
10	specifically	specifically	RB	RB	_	9	advmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	neutralizing	neutralize	VBG	VBG	_	13	amod	_	_
13	Abs	ab	NNS	NNS	_	9	nmod	_	_
14	to	to	TO	TO	_	18	case	_	_
15	basic	basic	JJ	JJ	_	18	amod	_	_
16	fibroblast	fibroblast	NN	NN	_	18	compound	_	_
17	growth	growth	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	9	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	bFGF	bfgf	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	9	punct	_	_
23	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
24	a	a	DT	DT	_	25	det	_	_
25	role	role	NN	NN	_	23	dobj	_	_
26	for	for	IN	IN	_	28	case	_	_
27	FGF	fgf	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	25	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	signaling	signaling	NN	NN	_	32	compound	_	_
32	process	process	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	Signaling	signal	VBG	VBG	_	7	nsubj	_	_
2	through	through	IN	IN	_	6	case	_	_
3	HLA	hla	NN	NN	_	6	compound	_	_
4	class	class	NN	NN	_	6	compound	_	_
5	I	i	CD	CD	_	6	nummod	_	_
6	molecules	molecule	NNS	NNS	_	1	nmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	cyclin	cyclin	NN	NN	_	11	compound	_	_
9	E-associated	e-associated	JJ	JJ	_	11	amod	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	dobj	_	_
12	within	within	IN	IN	_	14	case	_	_
13	4	4	CD	CD	_	14	nummod	_	_
14	h	h	NN	NN	_	7	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	quiescent	quiescent	JJ	JJ	_	18	amod	_	_
17	endothelial	endothelial	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	7	nmod	_	_
19	,	,	,	,	_	7	punct	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	appeared	appear	VBD	VBD	_	7	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	mediate	mediate	VB	VB	_	21	xcomp	_	_
24	the	the	DT	DT	_	25	det	_	_
25	inactivation	inactivation	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	Rb	rb	NN	NN	_	25	nmod	_	_
28	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	cdk2	cdk2	NN	NN	_	3	compound	_	_
3	inhibitor	inhibitor	NN	NN	_	14	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	Olomoucine	olomoucine	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	as	as	RB	RB	_	3	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	a	a	DT	DT	_	13	det	_	_
11	dominant-negative	dominant-negative	JJ	JJ	_	13	amod	_	_
12	cdk2	cdk2	NN	NN	_	13	compound	_	_
13	construct	construct	NN	NN	_	3	conj	_	_
14	prevented	prevent	VBD	VBD	_	30	dep	_	_
15	HLA	hla	NN	NN	_	18	compound	_	_
16	class	class	NN	NN	_	18	compound	_	_
17	I-mediated	i-mediated	JJ	JJ	_	18	amod	_	_
18	inactivation	inactivation	NN	NN	_	14	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Rb	rb	NN	NN	_	18	nmod	_	_
21	;	;	:	:	_	30	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	contrast	contrast	NN	NN	_	30	nmod	_	_
24	,	,	,	,	_	30	punct	_	_
25	dominant-negative	dominant-negative	JJ	JJ	_	26	amod	_	_
26	cdk4	cdk4	NN	NN	_	30	nsubj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	cdk6	cdk6	NN	NN	_	26	conj	_	_
29	constructs	construct	NNS	NNS	_	26	dep	_	_
30	had	have	VBD	VBD	_	0	root	_	_
31	no	no	DT	DT	_	32	neg	_	_
32	effect	effect	NN	NN	_	30	dobj	_	_
33	.	.	.	.	_	30	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	increase	increase	NN	NN	_	4	nsubj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	cyclin	cyclin	NN	NN	_	11	compound	_	_
9	D-associated	d-associated	JJ	JJ	_	11	amod	_	_
10	kinase	kinase	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	6	nmod	_	_
12	upon	upon	IN	IN	_	16	case	_	_
13	HLA	hla	NN	NN	_	16	compound	_	_
14	class	class	NN	NN	_	16	compound	_	_
15	I	i	CD	CD	_	16	nummod	_	_
16	ligation	ligation	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	suggesting	suggest	VBG	VBG	_	6	dep	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	cyclin	cyclin	NN	NN	_	23	compound	_	_
21	E-dependent	e-dependent	JJ	JJ	_	23	amod	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	24	nsubj	_	_
24	mediates	mediate	VBZ	VBZ	_	18	ccomp	_	_
25	Rb	rb	NN	NN	_	26	compound	_	_
26	inactivation	inactivation	NN	NN	_	24	dobj	_	_
27	,	,	,	,	_	24	punct	_	_
28	leading	lead	VBG	VBG	_	24	advcl	_	_
29	to	to	TO	TO	_	31	case	_	_
30	E2F	e2f	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	proliferation	proliferation	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	4	punct	_	_

1	Thrombin-induced	thrombin-induced	JJ	JJ	_	3	amod	_	_
2	p65	p65	NN	NN	_	3	compound	_	_
3	homodimer	homodimer	NN	NN	_	13	nsubj	_	_
4	binding	binding	NN	NN	_	3	dep	_	_
5	to	to	TO	TO	_	9	case	_	_
6	downstream	downstream	JJ	JJ	_	9	amod	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	promoter	promoter	NN	NN	_	9	nmod	_	_
13	mediates	mediate	VBZ	VBZ	_	0	root	_	_
14	endothelial	endothelial	JJ	JJ	_	16	amod	_	_
15	ICAM-1	icam-1	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	neutrophil	neutrophil	NN	NN	_	19	compound	_	_
19	adhesion	adhesion	NN	NN	_	16	conj	_	_
20	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	20	nmod	_	_
7	proinflammatory	proinflammatory	JJ	JJ	_	8	amod	_	_
8	mediator	mediator	NN	NN	_	20	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	thrombin	thrombin	NN	NN	_	8	appos	_	_
11	,	,	,	,	_	8	punct	_	_
12	released	release	VBN	VBN	_	8	acl	_	_
13	during	during	IN	IN	_	15	case	_	_
14	intravascular	intravascular	JJ	JJ	_	15	amod	_	_
15	coagulation	coagulation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	tissue	tissue	NN	NN	_	18	compound	_	_
18	injury	injury	NN	NN	_	15	conj	_	_
19	,	,	,	,	_	20	punct	_	_
20	induces	induce	VBZ	VBZ	_	4	acl:relcl	_	_
21	ICAM-1	icam-1	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	CD54	cd54	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	expression	expression	NN	NN	_	20	dobj	_	_
26	in	in	IN	IN	_	28	case	_	_
27	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Stimulation	stimulation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	HUVEC	huvec	NN	NN	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	thrombin	thrombin	NN	NN	_	1	nmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	dose-	dose-	NN	NN	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	time-dependent	time-dependent	JJ	JJ	_	8	conj	_	_
11	increases	increase	NNS	NNS	_	6	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	ICAM-1	icam-1	NN	NN	_	14	compound	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	surface	surface	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	14	conj	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	in	in	IN	IN	_	23	case	_	_
21	ICAM-1-dependent	icam-1-dependent	JJ	JJ	_	23	amod	_	_
22	endothelial	endothelial	JJ	JJ	_	23	amod	_	_
23	adhesivity	adhesivity	NN	NN	_	11	conj	_	_
24	toward	toward	IN	IN	_	26	case	_	_
25	polymorphonuclear	polymorphonuclear	JJ	JJ	_	26	amod	_	_
26	leukocytes	leukocyte	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfection	transfection	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	endothelial	endothelial	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	15	case	_	_
7	ICAM-1	icam-1	NN	NN	_	11	compound	_	_
8	promoter	promoter	NN	NN	_	11	compound	_	_
9	luciferase	luciferase	NN	NN	_	11	compound	_	_
10	reporter	reporter	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	11	punct	_	_
13	ICAM-1LUC	icam-1luc	NN	NN	_	11	dep	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	constructs	construct	NNS	NNS	_	2	nmod	_	_
16	indicated	indicate	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	32	mark	_	_
18	deletion	deletion	NN	NN	_	32	nsubj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	upstream	upstream	JJ	JJ	_	23	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	-533	-533	CD	CD	_	26	nummod	_	_
26	bases	basis	NNS	NNS	_	23	dep	_	_
27	from	from	IN	IN	_	30	case	_	_
28	translation	translation	NN	NN	_	30	compound	_	_
29	start	start	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	26	nmod	_	_
31	)	)	-RRB-	-RRB-	_	26	punct	_	_
32	had	have	VBD	VBD	_	16	ccomp	_	_
33	no	no	DT	DT	_	34	neg	_	_
34	effect	effect	NN	NN	_	32	dobj	_	_
35	on	on	IN	IN	_	37	case	_	_
36	thrombin	thrombin	NN	NN	_	37	compound	_	_
37	responsiveness	responsiveness	NN	NN	_	34	nmod	_	_
38	,	,	,	,	_	32	punct	_	_
39	whereas	whereas	IN	IN	_	32	dep	_	_
40	mutation/deletion	mutation/deletion	NN	NN	_	55	nsubj	_	_
41	of	of	IN	IN	_	45	case	_	_
42	downstream	downstream	JJ	JJ	_	45	amod	_	_
43	NF-kappa	nf-kappa	NN	NN	_	45	compound	_	_
44	B	b	NN	NN	_	45	compound	_	_
45	site	site	NN	NN	_	40	nmod	_	_
46	(	(	-LRB-	-LRB-	_	48	punct	_	_
47	-223	-223	CD	CD	_	48	nummod	_	_
48	bases	basis	NNS	NNS	_	45	dep	_	_
49	from	from	IN	IN	_	53	case	_	_
50	the	the	DT	DT	_	53	det	_	_
51	translation	translation	NN	NN	_	53	compound	_	_
52	start	start	NN	NN	_	53	compound	_	_
53	site	site	NN	NN	_	48	nmod	_	_
54	)	)	-RRB-	-RRB-	_	48	punct	_	_
55	prevented	prevent	VBD	VBD	_	32	parataxis	_	_
56	the	the	DT	DT	_	57	det	_	_
57	activation	activation	NN	NN	_	55	dobj	_	_
58	of	of	IN	IN	_	60	case	_	_
59	ICAM-1	icam-1	NN	NN	_	60	compound	_	_
60	promoter	promoter	NN	NN	_	57	nmod	_	_
61	,	,	,	,	_	55	punct	_	_
62	indicating	indicate	VBG	VBG	_	55	advcl	_	_
63	that	that	IN	IN	_	70	mark	_	_
64	the	the	DT	DT	_	68	det	_	_
65	downstream	downstream	JJ	JJ	_	68	amod	_	_
66	NF-kappa	nf-kappa	NN	NN	_	68	compound	_	_
67	B	b	NN	NN	_	68	compound	_	_
68	site	site	NN	NN	_	70	nsubj	_	_
69	is	be	VBZ	VBZ	_	70	cop	_	_
70	critical	critical	JJ	JJ	_	62	ccomp	_	_
71	for	for	IN	IN	_	73	case	_	_
72	thrombin	thrombin	NN	NN	_	73	compound	_	_
73	inducibility	inducibility	NN	NN	_	70	nmod	_	_
74	.	.	.	.	_	16	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
2	B-directed	b-directed	JJ	JJ	_	4	amod	_	_
3	luciferase	luciferase	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	5	nsubj	_	_
5	increased	increase	VBD	VBD	_	0	root	_	_
6	approximately	approximately	RB	RB	_	7	advmod	_	_
7	3-fold	3-fold	RB	RB	_	5	dobj	_	_
8	when	when	WRB	WRB	_	33	advmod	_	_
9	cells	cell	NNS	NNS	_	33	nsubjpass	_	_
10	transfected	transfect	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	plasmid	plasmid	NN	NN	_	15	compound	_	_
14	pNF-kappa	pnf-kappa	NN	NN	_	15	compound	_	_
15	BLUC	bluc	NN	NN	_	10	nmod	_	_
16	containing	contain	VBG	VBG	_	15	acl	_	_
17	five	five	CD	CD	_	18	nummod	_	_
18	copies	copy	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	consensus	consensus	NN	NN	_	23	compound	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	18	nmod	_	_
24	linked	link	VBN	VBN	_	18	acl	_	_
25	to	to	TO	TO	_	31	case	_	_
26	a	a	DT	DT	_	31	det	_	_
27	minimal	minimal	JJ	JJ	_	31	amod	_	_
28	adenovirus	adenovirus	NN	NN	_	31	compound	_	_
29	E1B	e1b	NN	NN	_	31	compound	_	_
30	promoter-luciferase	promoter-luciferase	JJ	JJ	_	31	amod	_	_
31	gene	gene	NN	NN	_	24	nmod	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	exposed	expose	VBN	VBN	_	5	advcl	_	_
34	to	to	TO	TO	_	35	case	_	_
35	thrombin	thrombin	NN	NN	_	33	nmod	_	_
36	,	,	,	,	_	33	punct	_	_
37	indicating	indicate	VBG	VBG	_	33	xcomp	_	_
38	that	that	IN	IN	_	44	mark	_	_
39	activation	activation	NN	NN	_	44	nsubj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	NF-kappa	nf-kappa	NN	NN	_	42	compound	_	_
42	B	b	NN	NN	_	39	nmod	_	_
43	was	be	VBD	VBD	_	44	cop	_	_
44	essential	essential	JJ	JJ	_	37	ccomp	_	_
45	for	for	IN	IN	_	47	case	_	_
46	thrombin	thrombin	NN	NN	_	47	compound	_	_
47	response	response	NN	NN	_	44	nmod	_	_
48	.	.	.	.	_	5	punct	_	_

1	Gel	gel	NN	NN	_	3	compound	_	_
2	supershift	supershift	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	thrombin	thrombin	NN	NN	_	7	nsubj	_	_
7	induced	induce	VBD	VBD	_	4	ccomp	_	_
8	binding	binding	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
11	Bp65	bp65	NN	NN	_	8	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	Rel	rel	NN	NN	_	14	compound	_	_
14	A	a	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	to	to	TO	TO	_	20	case	_	_
17	downstream	downstream	JJ	JJ	_	20	amod	_	_
18	NF-kappa	nf-kappa	NN	NN	_	20	compound	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	7	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	ICAM-1	icam-1	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Thrombin	thrombin	NN	NN	_	4	compound	_	_
2	receptor	receptor	NN	NN	_	4	compound	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	peptide	peptide	NN	NN	_	19	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	14-amino-acid	14-amino-acid	JJ	JJ	_	8	amod	_	_
8	peptide	peptide	NN	NN	_	4	appos	_	_
9	representing	represent	VBG	VBG	_	4	acl	_	_
10	the	the	DT	DT	_	13	det	_	_
11	new	new	JJ	JJ	_	13	amod	_	_
12	NH2	nh2	NN	NN	_	13	compound	_	_
13	terminus	terminus	NN	NN	_	9	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	proteolytically	proteolytically	RB	RB	_	16	advmod	_	_
16	activated	activate	VBN	VBN	_	17	amod	_	_
17	receptor-1	receptor-1	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	19	punct	_	_
19	mimicked	mimic	VBD	VBD	_	0	root	_	_
20	thrombin	thrombin	NN	NN	_	22	nmod:poss	_	_
21	's	's	POS	POS	_	22	case	_	_
22	action	action	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	24	mark	_	_
24	inducing	induce	VBG	VBG	_	19	advcl	_	_
25	ICAM-1	icam-1	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	19	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	thrombin	thrombin	NN	NN	_	6	nsubj	_	_
6	activates	activate	VBZ	VBZ	_	3	ccomp	_	_
7	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
8	ICAM-1	icam-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	polymorphonuclear	polymorphonuclear	JJ	JJ	_	13	amod	_	_
12	leukocyte	leukocyte	NN	NN	_	13	compound	_	_
13	adhesion	adhesion	NN	NN	_	9	conj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
16	Bp65	bp65	NN	NN	_	6	nmod	_	_
17	binding	bind	VBG	VBG	_	16	acl	_	_
18	to	to	TO	TO	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	downstream	downstream	JJ	JJ	_	23	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	site	site	NN	NN	_	17	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	ICAM-1	icam-1	NN	NN	_	26	compound	_	_
26	promoter	promoter	NN	NN	_	23	nmod	_	_
27	after	after	IN	IN	_	31	case	_	_
28	proteolytically	proteolytically	RB	RB	_	29	advmod	_	_
29	activated	activate	VBN	VBN	_	31	amod	_	_
30	receptor-1	receptor-1	JJ	JJ	_	31	amod	_	_
31	activation	activation	NN	NN	_	6	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	4	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	airway	airway	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	glucocorticoid-insensitive	glucocorticoid-insensitive	JJ	JJ	_	10	amod	_	_
10	asthma	asthma	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GC	gc	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	-insensitive	-insensitive	JJ	JJ	_	6	amod	_	_
6	asthma	asthma	NN	NN	_	11	nsubj	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	challenging	challenging	JJ	JJ	_	11	amod	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	problem	problem	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	15	nsubjpass	_	_
13	can	can	MD	MD	_	15	aux	_	_
14	be	be	VB	VB	_	15	auxpass	_	_
15	associated	associate	VBN	VBN	_	11	acl:relcl	_	_
16	with	with	IN	IN	_	19	case	_	_
17	life-threatening	life-threatening	JJ	JJ	_	19	amod	_	_
18	disease	disease	NN	NN	_	19	compound	_	_
19	progression	progression	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	basis	basis	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	GC	gc	NN	NN	_	6	compound	_	_
6	insensitivity	insensitivity	NN	NN	_	3	nmod	_	_
7	is	be	VBZ	VBZ	_	8	aux	_	_
8	unknown	unknown	JJ	JJ	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Alternative	alternative	JJ	JJ	_	2	amod	_	_
2	splicing	splicing	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	10	case	_	_
4	the	the	DT	DT	_	10	det	_	_
5	GC	gc	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	GCR	gcr	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	pre-mRNA	pre-mrna	NN	NN	_	2	nmod	_	_
11	generates	generate	VBZ	VBZ	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	second	second	JJ	JJ	_	14	amod	_	_
14	GCR	gcr	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	14	punct	_	_
16	termed	term	VBN	VBN	_	14	acl	_	_
17	GCRbeta	gcrbeta	NN	NN	_	16	xcomp	_	_
18	,	,	,	,	_	14	punct	_	_
19	which	which	WDT	WDT	_	22	nsubj	_	_
20	does	do	VBZ	VBZ	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	bind	bind	VB	VB	_	14	acl:relcl	_	_
23	GC	gc	NN	NN	_	22	dobj	_	_
24	but	but	CC	CC	_	22	cc	_	_
25	antagonizes	antagonize	VBZ	VBZ	_	22	conj	_	_
26	the	the	DT	DT	_	28	det	_	_
27	transactivating	transactivating	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	classic	classic	JJ	JJ	_	32	amod	_	_
32	GCR	gcr	NN	NN	_	28	nmod	_	_
33	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	increased	increase	VBN	VBN	_	3	amod	_	_
3	expression	expression	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	GCRbeta	gcrbeta	NN	NN	_	3	nmod	_	_
6	could	could	MD	MD	_	7	aux	_	_
7	account	account	VB	VB	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	glucocorticoid	glucocorticoid	NN	NN	_	10	compound	_	_
10	insensitivity	insensitivity	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	7	punct	_	_

1	Bronchoalveolar	bronchoalveolar	JJ	JJ	_	2	amod	_	_
2	lavage	lavage	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	BAL	bal	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	peripheral	peripheral	JJ	JJ	_	11	amod	_	_
9	blood	blood	NN	NN	_	11	compound	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	PBMC	pbmc	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	examined	examine	VBN	VBN	_	0	root	_	_
17	for	for	IN	IN	_	19	case	_	_
18	GCRbeta	gcrbeta	NN	NN	_	19	compound	_	_
19	immunoreactivity	immunoreactivity	NN	NN	_	16	nmod	_	_
20	using	use	VBG	VBG	_	16	xcomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	GCRbeta-specific	gcrbeta-specific	JJ	JJ	_	23	amod	_	_
23	antibody	antibody	NN	NN	_	20	dobj	_	_
24	by	by	IN	IN	_	26	case	_	_
25	immunohistochemical	immunohistochemical	JJ	JJ	_	26	amod	_	_
26	staining	staining	NN	NN	_	16	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	localization	localization	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	GCRbeta	gcrbeta	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	performed	perform	VBN	VBN	_	0	root	_	_
8	using	use	VBG	VBG	_	7	xcomp	_	_
9	a	a	DT	DT	_	12	det	_	_
10	double	double	JJ	JJ	_	12	amod	_	_
11	immunostaining	immunostaining	JJ	JJ	_	12	amod	_	_
12	technique	technique	NN	NN	_	8	dobj	_	_
13	.	.	.	.	_	7	punct	_	_

1	Patients	patient	NNS	NNS	_	5	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	GC-insensitive	gc-insensitive	JJ	JJ	_	4	amod	_	_
4	asthma	asthma	NN	NN	_	1	nmod	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	higher	higher	JJR	JJR	_	9	amod	_	_
9	number	number	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	GCRbeta-immunoreactive	gcrbeta-immunoreactive	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
15	BAL	bal	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	peripheral	peripheral	JJ	JJ	_	15	conj	_	_
18	blood	blood	NN	NN	_	15	dep	_	_
19	than	than	IN	IN	_	21	case	_	_
20	GC-sensitive	gc-sensitive	JJ	JJ	_	21	amod	_	_
21	asthmatics	asthmatic	NNS	NNS	_	9	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	normal	normal	JJ	JJ	_	25	amod	_	_
24	control	control	JJ	JJ	_	25	amod	_	_
25	subjects	subject	NNS	NNS	_	21	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	GCRbeta	gcrbeta	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	10	nsubj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	GC-insensitive	gc-insensitive	JJ	JJ	_	7	amod	_	_
7	asthma	asthma	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	10	cop	_	_
9	particularly	particularly	RB	RB	_	10	advmod	_	_
10	high	high	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	14	case	_	_
12	airway	airway	NN	NN	_	14	compound	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	thought	think	VBN	VBN	_	14	acl:relcl	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	play	play	VB	VB	_	18	xcomp	_	_
21	a	a	DT	DT	_	23	det	_	_
22	major	major	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	pathogenesis	pathogenesis	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	asthma	asthma	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	GCRbeta	gcrbeta	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	9	case	_	_
9	specimens	specimen	NNS	NNS	_	7	nmod	_	_
10	from	from	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	airways	airway	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	12	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	chronic	chronic	JJ	JJ	_	17	amod	_	_
17	bronchitis	bronchitis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	chronic	chronic	JJ	JJ	_	3	amod	_	_
3	bronchitis	bronchitis	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	few	few	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	GCRbeta-positive	gcrbeta-positive	JJ	JJ	_	0	root	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	numbers	number	NNS	NNS	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	differ	differ	VB	VB	_	8	conj	_	_
15	significantly	significantly	RB	RB	_	14	advmod	_	_
16	from	from	IN	IN	_	19	case	_	_
17	normal	normal	JJ	JJ	_	19	amod	_	_
18	control	control	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	GC-insensitive	gc-insensitive	JJ	JJ	_	5	amod	_	_
5	asthma	asthma	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	2	ccomp	_	_
8	with	with	IN	IN	_	10	case	_	_
9	increased	increase	VBN	VBN	_	10	amod	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	GCRbeta	gcrbeta	NN	NN	_	14	compound	_	_
13	in	in	IN	IN	_	14	amod	_	_
14	airway	airway	NN	NN	_	10	nmod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	14	dep	_	_
17	.	.	.	.	_	2	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	Fas	fas	NN	NN	_	5	compound	_	_
4	ligand	ligand	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	death	death	NN	NN	_	5	conj	_	_
9	by	by	IN	IN	_	11	case	_	_
10	apoptosis-linked	apoptosis-linked	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	5	nmod	_	_
12	4	4	CD	CD	_	11	nummod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Programmed	program	VBN	VBN	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	death	death	NN	NN	_	6	nsubj	_	_
4	is	be	VBZ	VBZ	_	6	cop	_	_
5	a	a	DT	DT	_	6	det	_	_
6	process	process	NN	NN	_	0	root	_	_
7	required	require	VBN	VBN	_	6	acl	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	normal	normal	JJ	JJ	_	11	amod	_	_
11	development	development	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	an	a	DT	DT	_	14	det	_	_
14	organism	organism	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	One	one	CD	CD	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	best	best	JJS	JJS	_	5	dep	_	_
5	understood	understand	VBN	VBN	_	7	amod	_	_
6	apoptotic	apoptotic	JJ	JJ	_	7	amod	_	_
7	pathways	pathway	NNS	NNS	_	1	nmod	_	_
8	occurs	occur	VBZ	VBZ	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	mediated	mediate	VBN	VBN	_	8	conj	_	_
15	by	by	IN	IN	_	21	case	_	_
16	Fas/Fas	fas/fas	NN	NN	_	21	compound	_	_
17	ligand	ligand	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	FasL	fasl	NN	NN	_	21	compound	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	interaction	interaction	NN	NN	_	14	nmod	_	_
22	.	.	.	.	_	8	punct	_	_

1	During	during	IN	IN	_	2	case	_	_
2	studies	study	NNS	NNS	_	12	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	apoptosis	apoptosis	NN	NN	_	2	nmod	_	_
5	induced	induce	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell-receptor	cell-receptor	NN	NN	_	9	compound	_	_
9	engagement	engagement	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	identified	identify	VBD	VBD	_	0	root	_	_
13	ALG-4F	alg-4f	NN	NN	_	12	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	17	det	_	_
16	truncated	truncate	VBN	VBN	_	17	amod	_	_
17	transcript	transcript	NN	NN	_	13	appos	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	prevents	prevent	VBZ	VBZ	_	13	acl:relcl	_	_
20	T	t	NN	NN	_	23	compound	_	_
21	cell-receptor-induced	cell-receptor-induced	JJ	JJ	_	23	amod	_	_
22	FasL	fasl	NN	NN	_	23	compound	_	_
23	upregulation	upregulation	NN	NN	_	19	dobj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	death	death	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	12	punct	_	_

1	Overexpression	overexpression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	full-length	full-length	JJ	JJ	_	4	amod	_	_
4	ALG-4	alg-4	NN	NN	_	1	nmod	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	transcription	transcription	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	FasL	fasl	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	,	,	,	,	_	6	punct	_	_
11	consequently	consequently	RB	RB	_	6	advmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	apoptosis	apoptosis	NN	NN	_	6	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	ALG-4	alg-4	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	sufficient	sufficient	JJ	JJ	_	7	conj	_	_
10	for	for	IN	IN	_	12	case	_	_
11	FasL	fasl	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	7	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Fas/FasL	fas/fasl	NN	NN	_	2	compound	_	_
2	interaction	interaction	NN	NN	_	3	nsubj	_	_
3	initiates	initiate	VBZ	VBZ	_	0	root	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	death	death	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	many	many	JJ	JJ	_	9	amod	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	systems	system	NNS	NNS	_	3	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	dysregulation	dysregulation	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	a	a	DT	DT	_	16	det	_	_
16	mechanism	mechanism	NN	NN	_	3	conj	_	_
17	by	by	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	22	nmod	_	_
19	several	several	JJ	JJ	_	21	amod	_	_
20	pathologic	pathologic	JJ	JJ	_	21	amod	_	_
21	conditions	condition	NNS	NNS	_	22	nsubj	_	_
22	arise	arise	VBP	VBP	_	16	acl:relcl	_	_
23	.	.	.	.	_	3	punct	_	_

1	Understanding	understand	VBG	VBG	_	11	csubj	_	_
2	the	the	DT	DT	_	4	det	_	_
3	molecular	molecular	JJ	JJ	_	4	amod	_	_
4	mechanisms	mechanism	NNS	NNS	_	1	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	FasL	fasl	NN	NN	_	7	compound	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	could	could	MD	MD	_	11	aux	_	_
9	be	be	VB	VB	_	11	cop	_	_
10	very	very	RB	RB	_	11	advmod	_	_
11	useful	useful	JJ	JJ	_	0	root	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	elucidating	elucidate	VBG	VBG	_	11	dep	_	_
14	how	how	WRB	WRB	_	17	advmod	_	_
15	these	these	DT	DT	_	16	det	_	_
16	diseases	disease	NNS	NNS	_	17	nsubj	_	_
17	develop	develop	VBP	VBP	_	13	ccomp	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	identifying	identify	VBG	VBG	_	13	conj	_	_
21	potential	potential	JJ	JJ	_	23	amod	_	_
22	therapeutic	therapeutic	JJ	JJ	_	23	amod	_	_
23	targets	target	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	11	punct	_	_

1	High	high	JJ	JJ	_	5	amod	_	_
2	molecular	molecular	JJ	JJ	_	5	amod	_	_
3	weight	weight	NN	NN	_	5	compound	_	_
4	dextran	dextran	NN	NN	_	5	compound	_	_
5	sulfate	sulfate	NN	NN	_	6	nsubj	_	_
6	increases	increase	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	NF-kappaB-regulated	nf-kappab-regulated	JJ	JJ	_	11	amod	_	_
11	promoter	promoter	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	monocyte-derived	monocyte-derived	JJ	JJ	_	14	amod	_	_
14	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	known	know	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	sulfated	sulfated	JJ	JJ	_	6	amod	_	_
6	polysaccharides	polysaccharide	NNS	NNS	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	mimic	mimic	VB	VB	_	3	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	action	action	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	common	common	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	mitogens	mitogen	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	23	advcl	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	basis	basis	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	mitogenic	mitogenic	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	15	case	_	_
11	high	high	JJ	JJ	_	15	amod	_	_
12	molecular	molecular	JJ	JJ	_	15	amod	_	_
13	weight	weight	NN	NN	_	15	compound	_	_
14	dextran	dextran	NN	NN	_	15	compound	_	_
15	sulfate	sulfate	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	HMDS	hmds	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	23	punct	_	_
20	monocyte-derived	monocyte-derived	JJ	JJ	_	21	amod	_	_
21	macrophages	macrophage	NNS	NNS	_	23	nsubjpass	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	transfected	transfect	VBN	VBN	_	0	root	_	_
24	with	with	IN	IN	_	26	case	_	_
25	recombinant	recombinant	JJ	JJ	_	26	amod	_	_
26	plasmid	plasmid	NN	NN	_	23	nmod	_	_
27	containing	contain	VBG	VBG	_	26	dep	_	_
28	chloramphenicol	chloramphenicol	NN	NN	_	30	compound	_	_
29	acetyl	acetyl	NN	NN	_	30	compound	_	_
30	transferase	transferase	NN	NN	_	35	compound	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	CAT	cat	NN	NN	_	30	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	reporter	reporter	NN	NN	_	35	compound	_	_
35	gene	gene	NN	NN	_	27	dobj	_	_
36	under	under	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	control	control	NN	NN	_	23	nmod	_	_
39	of	of	IN	IN	_	48	case	_	_
40	the	the	DT	DT	_	48	det	_	_
41	HIV-1	hiv-1	NN	NN	_	48	compound	_	_
42	long	long	JJ	JJ	_	44	amod	_	_
43	terminal	terminal	JJ	JJ	_	44	amod	_	_
44	repeat	repeat	NN	NN	_	48	compound	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	LTR	ltr	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	promoter	promoter	NN	NN	_	38	nmod	_	_
49	,	,	,	,	_	48	punct	_	_
50	which	which	WDT	WDT	_	52	nsubjpass	_	_
51	is	be	VBZ	VBZ	_	52	auxpass	_	_
52	regulated	regulate	VBN	VBN	_	48	acl:relcl	_	_
53	by	by	IN	IN	_	55	case	_	_
54	transcription	transcription	NN	NN	_	55	compound	_	_
55	factor	factor	NN	NN	_	52	nmod	_	_
56	NF-kappaB	nf-kappab	NN	NN	_	55	dep	_	_
57	.	.	.	.	_	23	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	HMDS	hmds	NN	NN	_	14	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	similar	similar	JJ	JJ	_	4	amod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	bacterial	bacterial	JJ	JJ	_	9	amod	_	_
9	lipopolysaccharide	lipopolysaccharide	NN	NN	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	LPS	lps	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	14	punct	_	_
14	increases	increase	VBZ	VBZ	_	2	ccomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	expression	expression	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	CAT	cat	NN	NN	_	20	compound	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	nmod	_	_
21	suggesting	suggest	VBG	VBG	_	14	xcomp	_	_
22	increased	increase	VBN	VBN	_	23	amod	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activation	activation	NN	NN	_	5	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
5	correlated	correlate	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	increased	increase	VBN	VBN	_	9	amod	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	B7.1	b7.1	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	postulated	postulate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	this	this	DT	DT	_	7	det	_	_
6	NF-kappaB-regulated	nf-kappab-regulated	JJ	JJ	_	7	amod	_	_
7	promoter	promoter	NN	NN	_	9	nsubj	_	_
8	might	might	MD	MD	_	9	aux	_	_
9	play	play	VB	VB	_	3	ccomp	_	_
10	a	a	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	accessory	accessory	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	as	as	RB	RB	_	9	advmod	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	rate	rate	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	replication	replication	NN	NN	_	23	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	HIV-1	hiv-1	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	monocyte-derived	monocyte-derived	JJ	JJ	_	30	amod	_	_
30	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Differences	difference	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	3	case	_	_
3	phosphorylation	phosphorylation	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	IL-2R	il-2r	NN	NN	_	9	compound	_	_
7	associated	associated	JJ	JJ	_	9	amod	_	_
8	JAK/STAT	jak/stat	NN	NN	_	9	compound	_	_
9	proteins	protein	NNS	NNS	_	3	nmod	_	_
10	between	between	IN	IN	_	13	case	_	_
11	HTLV-I(+)	htlv-i(+)	JJ	JJ	_	13	amod	_	_
12	,	,	,	,	_	13	punct	_	_
13	IL-2-independent	il-2-independent	JJ	JJ	_	1	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	IL-2-dependent	il-2-dependent	JJ	JJ	_	13	conj	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	dep	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	uncultured	uncultured	JJ	JJ	_	21	amod	_	_
20	leukemic	leukemic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	conj	_	_
22	from	from	IN	IN	_	23	case	_	_
23	patients	patient	NNS	NNS	_	21	nmod	_	_
24	with	with	IN	IN	_	27	case	_	_
25	adult	adult	JJ	JJ	_	27	amod	_	_
26	T-cell	t-cell	NN	NN	_	27	compound	_	_
27	lymphoma/leukemia	lymphoma/leukemia	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	1	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	19	advcl	_	_
3	activation	activation	NN	NN	_	4	compound	_	_
4	status	status	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	IL-2R-associated	il-2r-associated	JJ	JJ	_	11	amod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	Jak/STAT	jak/stat	NN	NN	_	11	compound	_	_
10	)	)	-RRB-	-RRB-	_	11	punct	_	_
11	pathway	pathway	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	HTLV-I	htlv-i	NN	NN	_	16	compound	_	_
15	infected	infected	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	examined	examine	VBD	VBD	_	0	root	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Jak3	jak3	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	STAT3	stat3	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	STAT5	stat5	NN	NN	_	23	conj	_	_
29	in	in	IN	IN	_	33	case	_	_
30	several	several	JJ	JJ	_	33	amod	_	_
31	HTLV-I(+)	htlv-i(+)	JJ	JJ	_	33	amod	_	_
32	T-cell	t-cell	NN	NN	_	33	compound	_	_
33	lines	line	NNS	NNS	_	23	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	in	in	IN	IN	_	39	case	_	_
36	uncultured	uncultured	JJ	JJ	_	39	amod	_	_
37	leukemic	leukemic	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	33	conj	_	_
40	isolated	isolate	VBN	VBN	_	39	acl	_	_
41	from	from	IN	IN	_	42	case	_	_
42	patients	patient	NNS	NNS	_	40	nmod	_	_
43	with	with	IN	IN	_	46	case	_	_
44	adult	adult	JJ	JJ	_	46	amod	_	_
45	T-cell	t-cell	NN	NN	_	46	compound	_	_
46	lymphoma/leukemia	lymphoma/leukemia	NN	NN	_	42	nmod	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	ATLL	atll	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	.	.	.	.	_	19	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	basal	basal	JJ	JJ	_	3	amod	_	_
3	phosphorylation	phosphorylation	NN	NN	_	14	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Jak3	jak3	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	,	,	,	,	_	5	punct	_	_
8	usually	usually	RB	RB	_	5	advmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	STAT3	stat3	NN	NN	_	5	conj	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	STAT5	stat5	NN	NN	_	5	conj	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	20	case	_	_
16	all	all	DT	DT	_	20	det	_	_
17	four	four	CD	CD	_	20	nummod	_	_
18	IL-2-independent	il-2-independent	JJ	JJ	_	20	amod	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	14	nmod	_	_
21	tested	test	VBN	VBN	_	20	acl	_	_
22	,	,	,	,	_	20	punct	_	_
23	but	but	CC	CC	_	20	cc	_	_
24	in	in	IN	IN	_	25	case	_	_
25	none	none	NN	NN	_	20	conj	_	_
26	of	of	IN	IN	_	31	case	_	_
27	the	the	DT	DT	_	31	det	_	_
28	three	three	CD	CD	_	31	nummod	_	_
29	IL-2-dependent	il-2-dependent	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	lines	line	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	Similarly	similarly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	there	there	EX	EX	_	4	expl	_	_
4	was	be	VBD	VBD	_	0	root	_	_
5	no	no	DT	DT	_	8	neg	_	_
6	detectable	detectable	JJ	JJ	_	8	amod	_	_
7	basal	basal	JJ	JJ	_	8	amod	_	_
8	phosphorylation	phosphorylation	NN	NN	_	4	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Jak3	jak3	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	STAT5	stat5	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	ATLL	atll	NN	NN	_	19	compound	_	_
19	patients	patient	NNS	NNS	_	16	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	0/8	0/8	CD	CD	_	19	dep	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	0/3	0/3	CD	CD	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	respectively	respectively	RB	RB	_	21	dep	_	_
26	)	)	-RRB-	-RRB-	_	21	punct	_	_
27	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	stimulation	stimulation	NN	NN	_	6	nsubj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	IL-2	il-2	NN	NN	_	3	nmod	_	_
6	resulted	result	VBD	VBD	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	Jak3	jak3	NN	NN	_	11	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	STAT5	stat5	NN	NN	_	8	conj	_	_
11	phosphorylation	phosphorylation	NN	NN	_	6	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	both	both	CC	CC	_	16	cc:preconj	_	_
14	leukemic	leukemic	JJ	JJ	_	16	amod	_	_
15	ATLL	atll	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	IL-2-dependent	il-2-dependent	JJ	JJ	_	19	amod	_	_
19	lines	line	NNS	NNS	_	16	conj	_	_
20	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	expression	expression	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	SHP-1	shp-1	NN	NN	_	6	compound	_	_
6	phosphatase	phosphatase	NN	NN	_	3	nmod	_	_
7	which	which	WDT	WDT	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	negative	negative	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	6	acl:relcl	_	_
12	of	of	IN	IN	_	15	case	_	_
13	cytokine	cytokine	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	signaling	signaling	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	18	punct	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	lost	lose	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	24	case	_	_
20	most	most	JJS	JJS	_	24	amod	_	_
21	IL-2	il-2	NN	NN	_	24	compound	_	_
22	independent	independent	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	3/4	3/4	CD	CD	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	but	but	CC	CC	_	24	cc	_	_
29	not	not	RB	RB	_	34	neg	_	_
30	in	in	IN	IN	_	34	case	_	_
31	the	the	DT	DT	_	34	det	_	_
32	leukemic	leukemic	JJ	JJ	_	34	amod	_	_
33	ATLL	atll	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	24	conj	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	0/3	0/3	CD	CD	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	18	punct	_	_

1	Finally	finally	RB	RB	_	19	advmod	_	_
2	,	,	,	,	_	19	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	HTLV-I(+)	htlv-i(+)	JJ	JJ	_	6	amod	_	_
5	T-cell	t-cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	19	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	313	313	CD	CD	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	but	but	CC	CC	_	6	cc	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	the	the	DT	DT	_	13	det	_	_
13	control	control	NN	NN	_	6	conj	_	_
14	,	,	,	,	_	13	punct	_	_
15	HTLV-I(-)	htlv-i(-)	JJ	JJ	_	17	amod	_	_
16	T-cell	t-cell	NN	NN	_	17	compound	_	_
17	lines	line	NNS	NNS	_	13	appos	_	_
18	were	be	VBD	VBD	_	19	cop	_	_
19	resistant	resistant	JJ	JJ	_	0	root	_	_
20	to	to	TO	TO	_	21	case	_	_
21	rapamycin	rapamycin	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	its	its	PRP$	PRP$	_	26	nmod:poss	_	_
24	novel	novel	JJ	JJ	_	26	amod	_	_
25	analog	analog	NN	NN	_	26	compound	_	_
26	RAD	rad	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	1	1	LS	LS	_	13	dep	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	HTLV-I	htlv-i	NN	NN	_	8	compound	_	_
8	infection	infection	NN	NN	_	13	nsubj	_	_
9	per	per	FW	FW	_	10	dep	_	_
10	se	se	FW	FW	_	8	nmod	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	result	result	VB	VB	_	2	ccomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	phosphorylation	phosphorylation	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	Jak3	jak3	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	STAT3	stat3	NN	NN	_	20	conj	_	_
23	,	,	,	,	_	20	punct	_	_
24	and	and	CC	CC	_	20	cc	_	_
25	STAT5	stat5	NN	NN	_	20	conj	_	_
26	proteins	protein	NNS	NNS	_	20	dep	_	_
27	;	;	:	:	_	13	punct	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	2	2	LS	LS	_	13	dep	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	malignant	malignant	JJ	JJ	_	32	amod	_	_
32	transformation	transformation	NN	NN	_	42	nsubj	_	_
33	in	in	IN	IN	_	37	case	_	_
34	at	at	IN	IN	_	35	case	_	_
35	least	least	JJS	JJS	_	37	advmod	_	_
36	some	some	DT	DT	_	37	det	_	_
37	cases	case	NNS	NNS	_	32	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	ATLL	atll	NN	NN	_	37	nmod	_	_
40	does	do	VBZ	VBZ	_	42	aux	_	_
41	not	not	RB	RB	_	42	neg	_	_
42	require	require	VB	VB	_	13	dep	_	_
43	the	the	DT	DT	_	44	det	_	_
44	constitutive	constitutive	JJ	JJ	_	42	dobj	_	_
45	,	,	,	,	_	42	punct	_	_
46	but	but	CC	CC	_	42	cc	_	_
47	may	may	MD	MD	_	48	aux	_	_
48	require	require	VB	VB	_	42	conj	_	_
49	IL-2-induced	il-2-induced	JJ	JJ	_	51	amod	_	_
50	,	,	,	,	_	51	punct	_	_
51	activation	activation	NN	NN	_	48	dobj	_	_
52	of	of	IN	IN	_	56	case	_	_
53	the	the	DT	DT	_	56	det	_	_
54	IL-2R	il-2r	NN	NN	_	56	compound	_	_
55	Jak/STAT	jak/stat	NN	NN	_	56	compound	_	_
56	pathway	pathway	NN	NN	_	51	nmod	_	_
57	;	;	:	:	_	13	punct	_	_
58	and	and	CC	CC	_	13	cc	_	_
59	(	(	-LRB-	-LRB-	_	60	punct	_	_
60	3	3	LS	LS	_	13	conj	_	_
61	)	)	-RRB-	-RRB-	_	60	punct	_	_
62	there	there	EX	EX	_	63	expl	_	_
63	are	be	VBP	VBP	_	13	dep	_	_
64	major	major	JJ	JJ	_	65	amod	_	_
65	differences	difference	NNS	NNS	_	63	nsubj	_	_
66	in	in	IN	IN	_	69	case	_	_
67	T-cell	t-cell	NN	NN	_	69	compound	_	_
68	immortalization	immortalization	NN	NN	_	69	compound	_	_
69	mechanism	mechanism	NN	NN	_	65	nmod	_	_
70	(	(	-LRB-	-LRB-	_	71	punct	_	_
71	s	s	NNS	NNS	_	69	appos	_	_
72	)	)	-RRB-	-RRB-	_	71	punct	_	_
73	which	which	WDT	WDT	_	74	nsubj	_	_
74	appear	appear	VBP	VBP	_	65	acl:relcl	_	_
75	to	to	TO	TO	_	76	mark	_	_
76	involve	involve	VB	VB	_	74	xcomp	_	_
77	SHP-1	shp-1	NN	NN	_	76	dobj	_	_
78	and	and	CC	CC	_	77	cc	_	_
79	target	target	NN	NN	_	80	compound	_	_
80	molecules	molecule	NNS	NNS	_	77	conj	_	_
81	for	for	IN	IN	_	82	case	_	_
82	rapamycin	rapamycin	NN	NN	_	80	nmod	_	_
83	and	and	CC	CC	_	82	cc	_	_
84	RAD	rad	NN	NN	_	82	conj	_	_
85	.	.	.	.	_	2	punct	_	_

1	CTLA-4-Mediated	ctla-4-mediated	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	early	early	JJ	JJ	_	5	amod	_	_
5	events	event	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	proliferation	proliferation	NN	NN	_	5	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	CTLA-4	ctla-4	NN	NN	_	2	compound	_	_
2	engagement	engagement	NN	NN	_	5	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	mAbs	mab	NNS	NNS	_	2	nmod	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	while	while	IN	IN	_	9	dep	_	_
8	CD28	cd28	NN	NN	_	9	dep	_	_
9	enhances	enhance	VBZ	VBZ	_	5	parataxis	_	_
10	,	,	,	,	_	5	punct	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	5	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	proliferation	proliferation	NN	NN	_	12	conj	_	_
15	upon	upon	IN	IN	_	18	case	_	_
16	T	t	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	5	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	analyzed	analyze	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	mechanisms	mechanism	NNS	NNS	_	5	dobj	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	CTLA-4-mediated	ctla-4-mediated	JJ	JJ	_	11	amod	_	_
11	inhibition	inhibition	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	naive	naive	JJ	JJ	_	20	amod	_	_
18	CD4+	cd4+	JJ	JJ	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	using	use	VBG	VBG	_	5	xcomp	_	_
22	Ab	ab	NN	NN	_	23	compound	_	_
23	cross-linking	cross-linking	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	5	punct	_	_

1	CTLA-4	ctla-4	NN	NN	_	2	compound	_	_
2	ligation	ligation	NN	NN	_	3	nsubj	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	CD3/CD28-induced	cd3/cd28-induced	JJ	JJ	_	7	amod	_	_
5	IL-2	il-2	NN	NN	_	7	compound	_	_
6	mRNA	mrna	NN	NN	_	7	compound	_	_
7	accumulation	accumulation	NN	NN	_	3	dobj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	inhibiting	inhibit	VBG	VBG	_	3	advcl	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	transcription	transcription	NN	NN	_	9	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	appears	appear	VBZ	VBZ	_	11	acl:relcl	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	be	be	VB	VB	_	17	auxpass	_	_
17	mediated	mediate	VBN	VBN	_	14	xcomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	17	nmod	_	_
20	through	through	IN	IN	_	21	mark	_	_
21	decreasing	decrease	VBG	VBG	_	17	advcl	_	_
22	NF-AT	nf-at	NN	NN	_	23	compound	_	_
23	accumulation	accumulation	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	nuclei	nucleus	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	CTLA-4	ctla-4	NN	NN	_	4	compound	_	_
4	ligation	ligation	NN	NN	_	7	nsubj	_	_
5	did	do	VBD	VBD	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	appear	appear	VB	VB	_	0	root	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	affect	affect	VB	VB	_	7	xcomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CD28-mediated	cd28-mediated	JJ	JJ	_	12	amod	_	_
12	stabilization	stabilization	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	IL-2	il-2	NN	NN	_	15	compound	_	_
15	mRNA	mrna	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Further	further	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CTLA-4	ctla-4	NN	NN	_	4	compound	_	_
4	engagement	engagement	NN	NN	_	5	nsubj	_	_
5	inhibited	inhibit	VBD	VBD	_	0	root	_	_
6	progression	progression	NN	NN	_	5	dobj	_	_
7	through	through	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	cycle	cycle	NN	NN	_	5	nmod	_	_
11	by	by	IN	IN	_	12	mark	_	_
12	inhibiting	inhibit	VBG	VBG	_	5	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	production	production	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	cyclin	cyclin	NN	NN	_	17	compound	_	_
17	D3	d3	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	cyclin-dependent	cyclin-dependent	JJ	JJ	_	20	amod	_	_
20	kinase	kinase	NN	NN	_	17	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	cdk	cdk	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	4	4	CD	CD	_	20	nummod	_	_
25	,	,	,	,	_	17	punct	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	cdk6	cdk6	NN	NN	_	17	conj	_	_
28	when	when	WRB	WRB	_	33	advmod	_	_
29	the	the	DT	DT	_	31	det	_	_
30	T	t	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	stimulated	stimulate	VBN	VBN	_	5	advcl	_	_
34	with	with	IN	IN	_	35	case	_	_
35	anti-CD3/CD28	anti-cd3/cd28	NN	NN	_	33	nmod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	with	with	IN	IN	_	38	case	_	_
38	anti-CD3	anti-cd3	NN	NN	_	35	conj	_	_
39	alone	alone	RB	RB	_	38	amod	_	_
40	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	CTLA-4	ctla-4	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	7	nsubj	_	_
7	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
8	events	event	NNS	NNS	_	7	dobj	_	_
9	early	early	RB	RB	_	7	advcl	_	_
10	in	in	IN	IN	_	13	case	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	both	both	CC	CC	_	17	cc:preconj	_	_
15	at	at	IN	IN	_	17	case	_	_
16	IL-2	il-2	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	7	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	at	at	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	level	level	NN	NN	_	17	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	IL-2-independent	il-2-independent	JJ	JJ	_	24	amod	_	_
24	events	event	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	cycle	cycle	NN	NN	_	24	nmod	_	_
29	,	,	,	,	_	7	punct	_	_
30	and	and	CC	CC	_	7	cc	_	_
31	does	do	VBZ	VBZ	_	34	aux	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	simply	simply	RB	RB	_	34	advmod	_	_
34	oppose	oppose	VB	VB	_	7	conj	_	_
35	CD28-mediated	cd28-mediated	JJ	JJ	_	36	amod	_	_
36	costimulation	costimulation	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	3	punct	_	_

1	Fibroblast	fibroblast	NN	NN	_	5	compound	_	_
2	growth	growth	NN	NN	_	5	compound	_	_
3	factor-1	factor-1	NN	NN	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	FGF-1	fgf-1	NN	NN	_	0	root	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	enhances	enhance	VBZ	VBZ	_	5	dep	_	_
8	IL-2	il-2	NN	NN	_	5	dep	_	_
9	production	production	NN	NN	_	5	dep	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	nuclear	nuclear	JJ	JJ	_	5	conj	_	_
12	translocation	translocation	NN	NN	_	5	dep	_	_
13	of	of	IN	IN	_	5	dep	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	5	dep	_	_
15	in	in	IN	IN	_	5	dep	_	_
16	FGF	fgf	NN	NN	_	5	dep	_	_
17	receptor-bearing	receptor-bearing	JJ	JJ	_	5	dep	_	_
18	Jurkat	jurkat	NN	NN	_	5	dep	_	_
19	T	t	NN	NN	_	5	dep	_	_
20	cells	cell	NNS	NNS	_	5	dep	_	_
21	.	.	.	.	_	5	punct	_	_

1	Fibroblast	fibroblast	NN	NN	_	11	dep	_	_
2	growth	growth	NN	NN	_	11	dep	_	_
3	factors	factor	NNS	NNS	_	11	dep	_	_
4	(	(	-LRB-	-LRB-	_	11	punct	_	_
5	FGFs	fgf	NNS	NNS	_	11	dep	_	_
6	)	)	-RRB-	-RRB-	_	11	punct	_	_
7	are	be	VBP	VBP	_	11	dep	_	_
8	heparin-binding	heparin-binding	JJ	JJ	_	11	dep	_	_
9	proteins	protein	NNS	NNS	_	11	dep	_	_
10	crucial	crucial	JJ	JJ	_	11	dep	_	_
11	to	to	TO	TO	_	0	root	_	_
12	embryogenesis	embryogenesis	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	11	punct	_	_
14	angiogenesis	angiogenesis	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	wound	wound	NN	NN	_	11	conj	_	_
18	healing	healing	NN	NN	_	11	dep	_	_
19	.	.	.	.	_	11	punct	_	_

1	FGF-1	fgf-1	NN	NN	_	20	dep	_	_
2	is	be	VBZ	VBZ	_	20	dep	_	_
3	abundantly	abundantly	RB	RB	_	20	advmod	_	_
4	expressed	express	VBN	VBN	_	20	dep	_	_
5	in	in	IN	IN	_	20	dep	_	_
6	the	the	DT	DT	_	20	dep	_	_
7	synovium	synovium	NN	NN	_	20	dep	_	_
8	in	in	IN	IN	_	20	dep	_	_
9	rheumatoid	rheumatoid	NN	NN	_	20	dep	_	_
10	arthritis	arthritis	NN	NN	_	20	dep	_	_
11	and	and	CC	CC	_	20	cc	_	_
12	in	in	IN	IN	_	20	conj	_	_
13	rejecting	reject	VBG	VBG	_	20	dep	_	_
14	allografts	allograft	NNS	NNS	_	20	dep	_	_
15	,	,	,	,	_	20	punct	_	_
16	sites	site	NNS	NNS	_	20	dep	_	_
17	of	of	IN	IN	_	20	dep	_	_
18	chronic	chronic	JJ	JJ	_	20	dep	_	_
19	immune-mediated	immune-mediated	JJ	JJ	_	20	dep	_	_
20	inflammation	inflammation	NN	NN	_	0	root	_	_
21	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	32	dep	_	_
2	frequency	frequency	NN	NN	_	32	dep	_	_
3	of	of	IN	IN	_	32	dep	_	_
4	FGF-1-responsive	fgf-1-responsive	JJ	JJ	_	32	dep	_	_
5	T	t	NN	NN	_	32	dep	_	_
6	cells	cell	NNS	NNS	_	32	dep	_	_
7	is	be	VBZ	VBZ	_	32	dep	_	_
8	increased	increase	VBN	VBN	_	32	dep	_	_
9	in	in	IN	IN	_	32	dep	_	_
10	the	the	DT	DT	_	32	dep	_	_
11	peripheral	peripheral	JJ	JJ	_	32	dep	_	_
12	blood	blood	NN	NN	_	32	dep	_	_
13	of	of	IN	IN	_	32	dep	_	_
14	these	these	DT	DT	_	32	dep	_	_
15	disorders	disorder	NNS	NNS	_	32	dep	_	_
16	,	,	,	,	_	32	punct	_	_
17	and	and	CC	CC	_	32	cc	_	_
18	a	a	DT	DT	_	32	conj	_	_
19	high	high	JJ	JJ	_	32	dep	_	_
20	percentage	percentage	NN	NN	_	32	dep	_	_
21	of	of	IN	IN	_	32	dep	_	_
22	infiltrating	infiltrate	VBG	VBG	_	32	dep	_	_
23	T	t	NN	NN	_	32	dep	_	_
24	cells	cell	NNS	NNS	_	32	dep	_	_
25	in	in	IN	IN	_	32	dep	_	_
26	rheumatoid	rheumatoid	JJ	JJ	_	32	dep	_	_
27	arthritis	arthritis	NN	NN	_	32	dep	_	_
28	synovium	synovium	NN	NN	_	32	dep	_	_
29	express	express	VBP	VBP	_	32	dep	_	_
30	receptors	receptor	NNS	NNS	_	32	dep	_	_
31	for	for	IN	IN	_	32	dep	_	_
32	FGF-1	fgf-1	NN	NN	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	To	to	TO	TO	_	0	root	_	_
2	understand	understand	VB	VB	_	1	dep	_	_
3	the	the	DT	DT	_	1	dep	_	_
4	action	action	NN	NN	_	1	dep	_	_
5	of	of	IN	IN	_	1	dep	_	_
6	FGF-1	fgf-1	NN	NN	_	1	dep	_	_
7	in	in	IN	IN	_	1	dep	_	_
8	T	t	NN	NN	_	1	dep	_	_
9	cells	cell	NNS	NNS	_	1	dep	_	_
10	,	,	,	,	_	1	punct	_	_
11	studies	study	NNS	NNS	_	1	dep	_	_
12	were	be	VBD	VBD	_	1	dep	_	_
13	initiated	initiate	VBN	VBN	_	1	dep	_	_
14	in	in	IN	IN	_	1	dep	_	_
15	Jurkat	jurkat	NN	NN	_	1	dep	_	_
16	T	t	NN	NN	_	1	dep	_	_
17	cells	cell	NNS	NNS	_	1	dep	_	_
18	that	that	WDT	WDT	_	1	dep	_	_
19	express	express	VBP	VBP	_	1	dep	_	_
20	the	the	DT	DT	_	1	dep	_	_
21	signaling	signaling	JJ	JJ	_	1	dep	_	_
22	isoform	isoform	NN	NN	_	1	dep	_	_
23	of	of	IN	IN	_	1	dep	_	_
24	FGF	fgf	NN	NN	_	1	dep	_	_
25	receptor-1	receptor-1	NN	NN	_	1	dep	_	_
26	.	.	.	.	_	1	punct	_	_

1	These	these	DT	DT	_	19	dep	_	_
2	experiments	experiment	NNS	NNS	_	19	dep	_	_
3	show	show	VBP	VBP	_	19	dep	_	_
4	that	that	IN	IN	_	19	dep	_	_
5	FGF-1	fgf-1	NN	NN	_	19	dep	_	_
6	stimulation	stimulation	NN	NN	_	19	dep	_	_
7	of	of	IN	IN	_	19	dep	_	_
8	Jurkat	jurkat	NN	NN	_	19	dep	_	_
9	T	t	NN	NN	_	19	dep	_	_
10	cells	cell	NNS	NNS	_	19	dep	_	_
11	provides	provide	VBZ	VBZ	_	19	dep	_	_
12	a	a	DT	DT	_	19	dep	_	_
13	second	second	JJ	JJ	_	19	dep	_	_
14	signal	signal	NN	NN	_	19	dep	_	_
15	that	that	WDT	WDT	_	19	dep	_	_
16	augments	augment	VBZ	VBZ	_	19	dep	_	_
17	TCR-mediated	tcr-mediated	JJ	JJ	_	19	dep	_	_
18	IL-2	il-2	NN	NN	_	19	dep	_	_
19	production	production	NN	NN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Analogous	analogous	JJ	JJ	_	2	dep	_	_
2	to	to	TO	TO	_	0	root	_	_
3	costimulation	costimulation	NN	NN	_	2	dep	_	_
4	via	via	IN	IN	_	2	dep	_	_
5	CD28	cd28	NN	NN	_	2	dep	_	_
6	,	,	,	,	_	2	punct	_	_
7	this	this	DT	DT	_	2	dep	_	_
8	activity	activity	NN	NN	_	2	dep	_	_
9	is	be	VBZ	VBZ	_	2	dep	_	_
10	mediated	mediate	VBN	VBN	_	2	dep	_	_
11	through	through	IN	IN	_	2	dep	_	_
12	activation	activation	NN	NN	_	2	dep	_	_
13	of	of	IN	IN	_	2	dep	_	_
14	Rel/kappaB	rel/kappab	NN	NN	_	2	dep	_	_
15	,	,	,	,	_	2	punct	_	_
16	a	a	DT	DT	_	2	dep	_	_
17	family	family	NN	NN	_	2	dep	_	_
18	of	of	IN	IN	_	2	dep	_	_
19	transcription	transcription	NN	NN	_	2	dep	_	_
20	factors	factor	NNS	NNS	_	2	dep	_	_
21	known	know	VBN	VBN	_	2	dep	_	_
22	to	to	TO	TO	_	2	dep	_	_
23	regulate	regulate	VB	VB	_	2	dep	_	_
24	IL-2	il-2	NN	NN	_	2	dep	_	_
25	and	and	CC	CC	_	2	cc	_	_
26	other	other	JJ	JJ	_	2	conj	_	_
27	activation-inducible	activation-inducible	JJ	JJ	_	2	dep	_	_
28	proteins	protein	NNS	NNS	_	2	dep	_	_
29	.	.	.	.	_	2	punct	_	_

1	FGF-1	fgf-1	NN	NN	_	20	dep	_	_
2	alone	alone	RB	RB	_	20	advmod	_	_
3	induces	induce	VBZ	VBZ	_	20	dep	_	_
4	modest	modest	JJ	JJ	_	20	dep	_	_
5	nuclear	nuclear	JJ	JJ	_	20	dep	_	_
6	translocation	translocation	NN	NN	_	20	dep	_	_
7	of	of	IN	IN	_	20	dep	_	_
8	kappaB-binding	kappab-binding	JJ	JJ	_	20	dep	_	_
9	proteins	protein	NNS	NNS	_	20	dep	_	_
10	,	,	,	,	_	20	punct	_	_
11	and	and	CC	CC	_	20	cc	_	_
12	this	this	DT	DT	_	20	conj	_	_
13	translocation	translocation	NN	NN	_	20	dep	_	_
14	is	be	VBZ	VBZ	_	20	dep	_	_
15	enhanced	enhance	VBN	VBN	_	20	dep	_	_
16	by	by	IN	IN	_	20	dep	_	_
17	the	the	DT	DT	_	20	dep	_	_
18	combination	combination	NN	NN	_	20	dep	_	_
19	of	of	IN	IN	_	20	dep	_	_
20	anti-CD3	anti-cd3	JJ	JJ	_	0	root	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	FGF-1	fgf-1	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	20	punct	_	_

1	This	this	DT	DT	_	33	dep	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	33	dep	_	_
3	binding	binding	NN	NN	_	33	dep	_	_
4	complex	complex	NN	NN	_	33	dep	_	_
5	is	be	VBZ	VBZ	_	33	dep	_	_
6	composed	compose	VBN	VBN	_	33	dep	_	_
7	of	of	IN	IN	_	33	dep	_	_
8	transcriptionally	transcriptionally	RB	RB	_	33	advmod	_	_
9	active	active	JJ	JJ	_	33	dep	_	_
10	p65	p65	NN	NN	_	33	dep	_	_
11	(	(	-LRB-	-LRB-	_	33	punct	_	_
12	RelA	rela	NN	NN	_	33	dep	_	_
13	)	)	-RRB-	-RRB-	_	33	punct	_	_
14	/p50	/p50	NN	NN	_	33	dep	_	_
15	heterodimers	heterodimer	NNS	NNS	_	33	dep	_	_
16	and	and	CC	CC	_	33	cc	_	_
17	results	result	VBZ	VBZ	_	33	conj	_	_
18	primarily	primarily	RB	RB	_	33	advmod	_	_
19	from	from	IN	IN	_	33	dep	_	_
20	the	the	DT	DT	_	33	dep	_	_
21	targeted	target	VBN	VBN	_	33	dep	_	_
22	degradation	degradation	NN	NN	_	33	dep	_	_
23	of	of	IN	IN	_	33	dep	_	_
24	IkappaB-alpha	ikappab-alpha	NN	NN	_	33	dep	_	_
25	,	,	,	,	_	33	punct	_	_
26	an	a	DT	DT	_	33	dep	_	_
27	inhibitor	inhibitor	NN	NN	_	33	dep	_	_
28	that	that	WDT	WDT	_	33	dep	_	_
29	sequesters	sequester	VBZ	VBZ	_	33	dep	_	_
30	Rel/kappaB	rel/kappab	NN	NN	_	33	dep	_	_
31	in	in	IN	IN	_	33	dep	_	_
32	the	the	DT	DT	_	33	dep	_	_
33	cytoplasm	cytoplasm	NN	NN	_	0	root	_	_
34	.	.	.	.	_	33	punct	_	_

1	These	these	DT	DT	_	6	dep	_	_
2	data	datum	NNS	NNS	_	6	dep	_	_
3	are	be	VBP	VBP	_	6	dep	_	_
4	the	the	DT	DT	_	6	dep	_	_
5	first	first	JJ	JJ	_	6	dep	_	_
6	to	to	TO	TO	_	0	root	_	_
7	show	show	VB	VB	_	6	dep	_	_
8	a	a	DT	DT	_	6	dep	_	_
9	connection	connection	NN	NN	_	6	dep	_	_
10	between	between	IN	IN	_	6	dep	_	_
11	FGF-1	fgf-1	NN	NN	_	6	dep	_	_
12	signaling	signaling	NN	NN	_	6	dep	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	6	conj	_	_
15	activation	activation	NN	NN	_	6	dep	_	_
16	outside	outside	IN	IN	_	6	dep	_	_
17	of	of	IN	IN	_	6	dep	_	_
18	embryonic	embryonic	JJ	JJ	_	6	dep	_	_
19	development	development	NN	NN	_	6	dep	_	_
20	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	43	dep	_	_
2	signaling	signaling	NN	NN	_	43	dep	_	_
3	events	event	NNS	NNS	_	43	dep	_	_
4	that	that	WDT	WDT	_	43	dep	_	_
5	link	link	VBP	VBP	_	43	dep	_	_
6	FGF	fgf	NN	NN	_	43	dep	_	_
7	receptor-1	receptor-1	NN	NN	_	43	dep	_	_
8	engagement	engagement	NN	NN	_	43	dep	_	_
9	and	and	CC	CC	_	43	cc	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	43	conj	_	_
11	activation	activation	NN	NN	_	43	dep	_	_
12	in	in	IN	IN	_	43	dep	_	_
13	Jurkat	jurkat	NN	NN	_	43	dep	_	_
14	are	be	VBP	VBP	_	43	dep	_	_
15	probably	probably	RB	RB	_	43	advmod	_	_
16	distinct	distinct	JJ	JJ	_	43	dep	_	_
17	from	from	IN	IN	_	43	dep	_	_
18	the	the	DT	DT	_	43	dep	_	_
19	CD28	cd28	NN	NN	_	43	dep	_	_
20	costimulation	costimulation	NN	NN	_	43	dep	_	_
21	pathway	pathway	NN	NN	_	43	dep	_	_
22	,	,	,	,	_	43	punct	_	_
23	since	since	IN	IN	_	43	dep	_	_
24	FGF-1-induced	fgf-1-induced	JJ	JJ	_	43	dep	_	_
25	Rel/kappaB	rel/kappab	NN	NN	_	43	dep	_	_
26	binding	binding	NN	NN	_	43	dep	_	_
27	proteins	protein	NNS	NNS	_	43	dep	_	_
28	do	do	VBP	VBP	_	43	dep	_	_
29	not	not	RB	RB	_	43	neg	_	_
30	contain	contain	VB	VB	_	43	dep	_	_
31	significant	significant	JJ	JJ	_	43	dep	_	_
32	levels	level	NNS	NNS	_	43	dep	_	_
33	of	of	IN	IN	_	43	dep	_	_
34	c-Rel	c-rel	NN	NN	_	43	dep	_	_
35	and	and	CC	CC	_	43	cc	_	_
36	are	be	VBP	VBP	_	43	conj	_	_
37	not	not	RB	RB	_	43	neg	_	_
38	identical	identical	JJ	JJ	_	43	dep	_	_
39	with	with	IN	IN	_	43	dep	_	_
40	the	the	DT	DT	_	43	dep	_	_
41	CD28	cd28	NN	NN	_	43	dep	_	_
42	response	response	NN	NN	_	43	dep	_	_
43	complex	complex	NN	NN	_	0	root	_	_
44	.	.	.	.	_	43	punct	_	_

1	USF/c-Myc	usf/c-myc	NN	NN	_	2	nsubj	_	_
2	enhances	enhance	VBZ	VBZ	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	while	while	IN	IN	_	7	mark	_	_
5	Yin-Yang	yin-yang	NN	NN	_	7	nsubj	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	suppresses	suppress	VBZ	VBZ	_	2	advcl	_	_
8	,	,	,	,	_	2	punct	_	_
9	the	the	DT	DT	_	11	det	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	2	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	CXCR4	cxcr4	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	coreceptor	coreceptor	NN	NN	_	13	appos	_	_
17	for	for	IN	IN	_	19	case	_	_
18	HIV-1	hiv-1	NN	NN	_	19	compound	_	_
19	entry	entry	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	Transcription	transcription	NN	NN	_	2	compound	_	_
2	factors	factor	NNS	NNS	_	6	nsubj	_	_
3	USF1	usf1	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	USF2	usf2	NN	NN	_	3	conj	_	_
6	up-regulate	up-regulate	VBP	VBP	_	0	root	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	(	(	-LRB-	-LRB-	_	15	punct	_	_
10	i.e.	i.e.	FW	FW	_	15	dep	_	_
11	,	,	,	,	_	15	punct	_	_
12	HIV-1	hiv-1	NN	NN	_	15	compound	_	_
13	long	long	JJ	JJ	_	15	amod	_	_
14	terminal	terminal	JJ	JJ	_	15	amod	_	_
15	repeats	repeat	NNS	NNS	_	8	nmod	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	via	via	IN	IN	_	18	case	_	_
18	interaction	interaction	NN	NN	_	6	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	E	e	NN	NN	_	22	compound	_	_
22	box	box	NN	NN	_	18	nmod	_	_
23	on	on	IN	IN	_	26	case	_	_
24	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
25	target	target	NN	NN	_	26	compound	_	_
26	promoters	promoter	NNS	NNS	_	18	nmod	_	_
27	,	,	,	,	_	18	punct	_	_
28	which	which	WDT	WDT	_	33	nsubj	_	_
29	is	be	VBZ	VBZ	_	33	cop	_	_
30	also	also	RB	RB	_	33	advmod	_	_
31	a	a	DT	DT	_	33	det	_	_
32	binding	bind	VBG	VBG	_	33	amod	_	_
33	site	site	NN	NN	_	18	acl:relcl	_	_
34	for	for	IN	IN	_	35	case	_	_
35	c-Myc	c-myc	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	c-Myc	c-myc	NN	NN	_	3	compound	_	_
3	oncoprotein	oncoprotein	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	control	control	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	proliferation	proliferation	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	differentiation	differentiation	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	5	punct	_	_
14	while	while	IN	IN	_	22	mark	_	_
15	Yin-Yang	yin-yang	NN	NN	_	22	nsubjpass	_	_
16	1	1	CD	CD	_	15	nummod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	YY1	yy1	NN	NN	_	15	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	has	have	VBZ	VBZ	_	22	aux	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	shown	show	VBN	VBN	_	5	advcl	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	control	control	VB	VB	_	22	xcomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	expression	expression	NN	NN	_	24	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	number	number	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	cellular	cellular	JJ	JJ	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	viral	viral	JJ	JJ	_	31	conj	_	_
34	genes	gene	NNS	NNS	_	31	dep	_	_
35	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	two	two	CD	CD	_	3	nummod	_	_
3	proteins	protein	NNS	NNS	_	5	nsubj	_	_
4	physically	physically	RB	RB	_	5	advmod	_	_
5	interact	interact	VBP	VBP	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	each	each	DT	DT	_	8	det	_	_
8	other	other	JJ	JJ	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	mutually	mutually	RB	RB	_	11	advmod	_	_
11	inhibit	inhibit	VBP	VBP	_	5	conj	_	_
12	their	they	PRP$	PRP$	_	15	nmod:poss	_	_
13	respective	respective	JJ	JJ	_	15	amod	_	_
14	biological	biological	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	11	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	USF/c-Myc	usf/c-myc	NN	NN	_	9	nsubj	_	_
9	up-regulates	up-regulate	VBZ	VBZ	_	6	ccomp	_	_
10	,	,	,	,	_	9	punct	_	_
11	while	while	IN	IN	_	13	mark	_	_
12	YY1	yy1	NN	NN	_	13	nsubj	_	_
13	down-regulates	down-regulate	VBZ	VBZ	_	9	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	promoter	promoter	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	9	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	CXCR4	cxcr4	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	21	det	_	_
21	coreceptor	coreceptor	NN	NN	_	18	appos	_	_
22	for	for	IN	IN	_	26	case	_	_
23	T	t	NN	NN	_	26	compound	_	_
24	cell-tropic	cell-tropic	JJ	JJ	_	26	amod	_	_
25	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
26	entry	entry	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	identified	identify	VBN	VBN	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	E	e	NN	NN	_	6	compound	_	_
6	box	box	NN	NN	_	3	dobj	_	_
7	around	around	IN	IN	_	8	case	_	_
8	-260	-260	CD	CD	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	a	a	DT	DT	_	13	det	_	_
11	YY1	yy1	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	6	conj	_	_
14	around	around	IN	IN	_	15	case	_	_
15	-300	-300	CD	CD	_	13	nmod	_	_
16	relative	relative	JJ	JJ	_	21	case	_	_
17	to	to	TO	TO	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	transcription	transcription	NN	NN	_	21	compound	_	_
20	start	start	NN	NN	_	21	compound	_	_
21	site	site	NN	NN	_	3	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Mutation	mutation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	E	e	NN	NN	_	5	compound	_	_
5	box	box	NN	NN	_	1	nmod	_	_
6	abolished	abolish	VBD	VBD	_	0	root	_	_
7	USF/c-Myc-mediated	usf/c-myc-mediated	JJ	JJ	_	8	amod	_	_
8	up-regulation	up-regulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	CXCR4	cxcr4	NN	NN	_	12	compound	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	mutation	mutation	NN	NN	_	22	nsubjpass	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	YY1	yy1	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	site	site	NN	NN	_	15	nmod	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	6	conj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	unresponsiveness	unresponsiveness	NN	NN	_	22	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	YY1-mediated	yy1-mediated	JJ	JJ	_	27	amod	_	_
27	inhibition	inhibition	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	USF/c-Myc	usf/c-myc	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	YY1	yy1	NN	NN	_	5	conj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	play	play	VB	VB	_	3	ccomp	_	_
10	an	a	DT	DT	_	12	det	_	_
11	important	important	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	HIV-1-replicative	hiv-1-replicative	JJ	JJ	_	16	amod	_	_
16	cycle	cycle	NN	NN	_	9	nmod	_	_
17	,	,	,	,	_	9	punct	_	_
18	by	by	IN	IN	_	19	mark	_	_
19	modulating	modulate	VBG	VBG	_	9	advcl	_	_
20	both	both	CC	CC	_	24	cc:preconj	_	_
21	the	the	DT	DT	_	24	dep	_	_
22	viral	viral	JJ	JJ	_	24	amod	_	_
23	fusion/entry	fusion/entry	NN	NN	_	24	compound	_	_
24	process	process	NN	NN	_	19	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	viral	viral	JJ	JJ	_	27	amod	_	_
27	expression	expression	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Signaling	signal	VBG	VBG	_	6	nsubj	_	_
2	through	through	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	lymphotoxin-beta	lymphotoxin-beta	NN	NN	_	5	compound	_	_
5	receptor	receptor	NN	NN	_	1	nmod	_	_
6	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
7	HIV-1	hiv-1	NN	NN	_	8	compound	_	_
8	replication	replication	NN	NN	_	6	dobj	_	_
9	alone	alone	RB	RB	_	10	advmod	_	_
10	and	and	CC	CC	_	6	advmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cooperation	cooperation	NN	NN	_	10	conj	_	_
13	with	with	IN	IN	_	14	case	_	_
14	soluble	soluble	JJ	JJ	_	12	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	membrane-bound	membrane-bound	JJ	JJ	_	17	amod	_	_
17	TNF-alpha	tnf-alpha	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	level	level	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	ongoing	ongoing	JJ	JJ	_	6	amod	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	replication	replication	NN	NN	_	2	nmod	_	_
7	within	within	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	individual	individual	NN	NN	_	2	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	critical	critical	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	14	case	_	_
13	HIV-1	hiv-1	NN	NN	_	14	compound	_	_
14	pathogenesis	pathogenesis	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	Among	among	IN	IN	_	4	case	_	_
2	host	host	NN	NN	_	4	compound	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	factors	factor	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	12	nsubjpass	_	_
9	has	have	VBZ	VBZ	_	12	aux	_	_
10	previously	previously	RB	RB	_	12	advmod	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	shown	show	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	increase	increase	VB	VB	_	12	xcomp	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	replication	replication	NN	NN	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	monocyte	monocyte	NN	NN	_	14	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	T	t	NN	NN	_	24	compound	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	model	model	NN	NN	_	24	compound	_	_
24	systems	system	NNS	NNS	_	19	conj	_	_
25	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	25	mark	_	_
6	signaling	signal	VBG	VBG	_	25	nsubj	_	_
7	through	through	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	TNF	tnf	NN	NN	_	12	compound	_	_
10	receptor	receptor	NN	NN	_	12	compound	_	_
11	family	family	NN	NN	_	12	compound	_	_
12	member	member	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	the	the	DT	DT	_	19	det	_	_
15	lymphotoxin-beta	lymphotoxin-beta	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	LT-beta	lt-beta	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	receptor	receptor	NN	NN	_	12	appos	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	LT-betaR	lt-betar	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	12	punct	_	_
24	also	also	RB	RB	_	25	advmod	_	_
25	regulates	regulate	VBZ	VBZ	_	4	ccomp	_	_
26	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
27	replication	replication	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	HIV-1	hiv-1	NN	NN	_	4	compound	_	_
4	replication	replication	NN	NN	_	7	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	cooperatively	cooperatively	RB	RB	_	7	advmod	_	_
7	stimulated	stimulate	VBN	VBN	_	0	root	_	_
8	when	when	WRB	WRB	_	18	advmod	_	_
9	the	the	DT	DT	_	11	dep	_	_
10	distinct	distinct	JJ	JJ	_	11	amod	_	_
11	LT-betaR	lt-betar	NN	NN	_	18	nsubjpass	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	TNF	tnf	NN	NN	_	15	compound	_	_
14	receptor	receptor	NN	NN	_	15	compound	_	_
15	systems	system	NNS	NNS	_	11	conj	_	_
16	are	be	VBP	VBP	_	18	auxpass	_	_
17	simultaneously	simultaneously	RB	RB	_	18	advmod	_	_
18	engaged	engage	VBN	VBN	_	7	ccomp	_	_
19	by	by	IN	IN	_	22	case	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	ligands	ligand	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Moreover	moreover	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	in	in	IN	IN	_	9	case	_	_
4	a	a	DT	DT	_	9	det	_	_
5	physiological	physiological	JJ	JJ	_	9	amod	_	_
6	coculture	coculture	NN	NN	_	9	compound	_	_
7	cellular	cellular	JJ	JJ	_	9	amod	_	_
8	assay	assay	NN	NN	_	9	compound	_	_
9	system	system	NN	NN	_	12	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	show	show	VBP	VBP	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	membrane-bound	membrane-bound	JJ	JJ	_	15	amod	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	18	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	LT-alpha1beta2	lt-alpha1beta2	NN	NN	_	15	conj	_	_
18	act	act	VBP	VBP	_	12	ccomp	_	_
19	virtually	virtually	RB	RB	_	18	advmod	_	_
20	identically	identically	RB	RB	_	18	advcl	_	_
21	to	to	TO	TO	_	24	case	_	_
22	their	they	PRP$	PRP$	_	24	nmod:poss	_	_
23	soluble	soluble	JJ	JJ	_	24	amod	_	_
24	forms	form	NNS	NNS	_	20	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	regulation	regulation	NN	NN	_	18	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	HIV-1	hiv-1	NN	NN	_	30	compound	_	_
30	replication	replication	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	cosignaling	cosignaling	NN	NN	_	12	nsubjpass	_	_
4	via	via	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	LT-beta	lt-beta	NN	NN	_	9	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	conj	_	_
9	receptors	receptor	NNS	NNS	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	probably	probably	RB	RB	_	12	advmod	_	_
12	involved	involve	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	modulation	modulation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	HIV-1	hiv-1	NN	NN	_	18	compound	_	_
18	replication	replication	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	subsequent	subsequent	JJ	JJ	_	22	amod	_	_
22	determination	determination	NN	NN	_	15	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	HIV-1	hiv-1	NN	NN	_	26	compound	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	burden	burden	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	26	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Intriguingly	intriguingly	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	surface	surface	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	LT-alpha1beta2	lt-alpha1beta2	NN	NN	_	4	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	up-	up-	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	on	on	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	line	line	NN	NN	_	9	nmod	_	_
15	acutely	acutely	RB	RB	_	16	advmod	_	_
16	infected	infect	VBN	VBN	_	14	acl	_	_
17	with	with	IN	IN	_	18	case	_	_
18	HIV-1	hiv-1	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	9	punct	_	_
20	suggesting	suggest	VBG	VBG	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	positive	positive	JJ	JJ	_	24	amod	_	_
23	feedback	feedback	NN	NN	_	24	compound	_	_
24	loop	loop	NN	NN	_	9	nmod	_	_
25	between	between	IN	IN	_	27	case	_	_
26	HIV-1	hiv-1	NN	NN	_	27	compound	_	_
27	infection	infection	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	LT-alpha1beta2	lt-alpha1beta2	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	27	conj	_	_
31	,	,	,	,	_	27	punct	_	_
32	and	and	CC	CC	_	27	cc	_	_
33	HIV-1	hiv-1	NN	NN	_	34	compound	_	_
34	replication	replication	NN	NN	_	27	conj	_	_
35	.	.	.	.	_	9	punct	_	_

1	Given	given	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	critical	critical	JJ	JJ	_	4	amod	_	_
4	role	role	NN	NN	_	13	nmod	_	_
5	that	that	WDT	WDT	_	7	dobj	_	_
6	LT-alpha1beta2	lt-alpha1beta2	NN	NN	_	7	nsubj	_	_
7	plays	play	VBZ	VBZ	_	4	acl:relcl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	lymphoid	lymphoid	JJ	JJ	_	10	amod	_	_
10	architecture	architecture	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	speculate	speculate	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	18	mark	_	_
15	LT-alpha1beta2	lt-alpha1beta2	NN	NN	_	18	nsubjpass	_	_
16	may	may	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	involved	involve	VBN	VBN	_	13	ccomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	HIV-associated	hiv-associated	JJ	JJ	_	21	amod	_	_
21	abnormalities	abnormality	NNS	NNS	_	18	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	lymphoid	lymphoid	JJ	JJ	_	25	amod	_	_
25	organs	organ	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	inflamed	inflamed	JJ	JJ	_	8	amod	_	_
7	colonic	colonic	JJ	JJ	_	8	amod	_	_
8	mucosa	mucosa	NN	NN	_	4	nmod	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	not	not	RB	RB	_	15	neg	_	_
11	in	in	IN	IN	_	15	case	_	_
12	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	mononuclear	mononuclear	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	8	conj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	inflammatory	inflammatory	JJ	JJ	_	21	amod	_	_
20	bowel	bowel	NN	NN	_	21	compound	_	_
21	disease	disease	NN	NN	_	17	nmod	_	_
22	-LSB-	-lsb-	-LRB-	-LRB-	_	23	punct	_	_
23	see	see	VB	VB	_	4	parataxis	_	_
24	comments	comment	NNS	NNS	_	23	dobj	_	_
25	-RSB-	-rsb-	-RRB-	-RRB-	_	23	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Growing	grow	VBG	VBG	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	5	nsubj	_	_
5	indicates	indicate	VBZ	VBZ	_	1	dep	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	15	nsubjpass	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	13	amod	_	_
13	system	system	NN	NN	_	9	conj	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	linked	link	VBN	VBN	_	5	ccomp	_	_
16	by	by	IN	IN	_	18	case	_	_
17	several	several	JJ	JJ	_	18	amod	_	_
18	mechanisms	mechanism	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	for	for	IN	IN	_	21	case	_	_
21	example	example	NN	NN	_	18	nmod	_	_
22	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	receptors	receptor	NNS	NNS	_	18	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	hGR	hgr	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	1	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	5	nsubj	_	_
2	are	be	VBP	VBP	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	standard	standard	JJ	JJ	_	5	amod	_	_
5	treatment	treatment	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	acute	acute	JJ	JJ	_	8	amod	_	_
8	attacks	attack	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	12	amod	_	_
11	bowel	bowel	NN	NN	_	12	compound	_	_
12	disease	disease	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	IBD	ibd	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	5	punct	_	_

1	Binding	binding	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	glucocorticoids	glucocorticoid	NNS	NNS	_	1	nmod	_	_
4	to	to	TO	TO	_	5	case	_	_
5	hGR	hgr	NN	NN	_	1	nmod	_	_
6	down-regulates	down-regulate	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	14	nsubj	_	_
13	can	can	MD	MD	_	14	aux	_	_
14	propagate	propagate	VB	VB	_	11	acl:relcl	_	_
15	IBD	ibd	NN	NN	_	14	dobj	_	_
16	.	.	.	.	_	6	punct	_	_

1	PATIENTS	patient	NNS	NNS	_	0	root	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	METHODS	method	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	1	punct	_	_
5	IBD	ibd	NN	NN	_	6	compound	_	_
6	patients	patient	NNS	NNS	_	9	nsubjpass	_	_
7	were	be	VBD	VBD	_	9	auxpass	_	_
8	either	either	RB	RB	_	9	advmod	_	_
9	treated	treat	VBN	VBN	_	1	dep	_	_
10	with	with	IN	IN	_	12	case	_	_
11	5-60	5-60	CD	CD	_	12	nummod	_	_
12	mg	mg	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	prednisolone	prednisolone	NN	NN	_	12	nmod	_	_
15	for	for	IN	IN	_	19	case	_	_
16	more	more	JJR	JJR	_	18	advmod	_	_
17	than	than	IN	IN	_	16	mwe	_	_
18	1	1	CD	CD	_	19	nummod	_	_
19	week	week	NN	NN	_	9	nmod	_	_
20	or	or	CC	CC	_	9	cc	_	_
21	were	be	VBD	VBD	_	24	cop	_	_
22	without	without	IN	IN	_	24	case	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	treatment	treatment	NN	NN	_	9	conj	_	_
25	for	for	IN	IN	_	29	case	_	_
26	more	more	JJR	JJR	_	28	advmod	_	_
27	than	than	IN	IN	_	26	mwe	_	_
28	4	4	CD	CD	_	29	nummod	_	_
29	weeks	week	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	1	punct	_	_

1	hGR	hgr	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	4	nsubj	_	_
3	were	be	VBD	VBD	_	4	dep	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	isolated	isolate	VBN	VBN	_	7	amod	_	_
7	cytosol	cytosol	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
10	blood	blood	NN	NN	_	12	compound	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	7	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	PBMCs	pbmc	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	or	or	CC	CC	_	7	cc	_	_
17	mucosal	mucosal	JJ	JJ	_	18	amod	_	_
18	biopsies	biopsy	NNS	NNS	_	7	conj	_	_
19	using	use	VBG	VBG	_	18	acl	_	_
20	a	a	DT	DT	_	21	det	_	_
21	radioassay	radioassay	NN	NN	_	19	dobj	_	_
22	with	with	IN	IN	_	23	case	_	_
23	-LSB-3H-RSB--dexamethasone	-lsb-3h-rsb--dexamethasone	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Interleukin	interleukin	NN	NN	_	6	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL	il	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	6	6	CD	CD	_	6	nummod	_	_
6	levels	level	NNS	NNS	_	8	nsubjpass	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	determined	determine	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	12	case	_	_
10	enzyme-linked	enzyme-linked	JJ	JJ	_	12	amod	_	_
11	immunosorbent	immunosorbent	JJ	JJ	_	12	amod	_	_
12	assay	assay	NN	NN	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	ELISA	elisa	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	.	.	.	.	_	8	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	The	the	DT	DT	_	9	det	_	_
4	systemic	systemic	JJ	JJ	_	9	amod	_	_
5	(	(	-LRB-	-LRB-	_	9	punct	_	_
6	PBMC	pbmc	NN	NN	_	9	compound	_	_
7	)	)	-RRB-	-RRB-	_	9	punct	_	_
8	hGR	hgr	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	16	nsubj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	corticosteroid-treated	corticosteroid-treated	JJ	JJ	_	13	amod	_	_
12	IBD	ibd	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	9	nmod	_	_
14	were	be	VBD	VBD	_	16	cop	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	lower	lower	JJR	JJR	_	1	dep	_	_
17	than	than	IN	IN	_	18	case	_	_
18	those	those	DT	DT	_	16	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	control	control	JJ	JJ	_	21	amod	_	_
21	subjects	subject	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	29	punct	_	_
23	59.6	59.6	CD	CD	_	29	compound	_	_
24	+/-	+/-	CC	CC	_	23	cc	_	_
25	57.1	57.1	CD	CD	_	23	conj	_	_
26	dpm	dpm	NN	NN	_	29	compound	_	_
27	mg-1	mg-1	NN	NN	_	29	compound	_	_
28	cytosol	cytosol	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	21	dep	_	_
30	vs.	vs.	CC	CC	_	29	cc	_	_
31	227.0	227.0	CD	CD	_	37	compound	_	_
32	+/-	+/-	CC	CC	_	31	cc	_	_
33	90.8	90.8	CD	CD	_	31	conj	_	_
34	dpm	dpm	NN	NN	_	37	compound	_	_
35	mg-1	mg-1	NN	NN	_	37	compound	_	_
36	cytosol	cytosol	NN	NN	_	37	compound	_	_
37	protein	protein	NN	NN	_	29	conj	_	_
38	,	,	,	,	_	29	punct	_	_
39	P	p	NN	NN	_	40	nsubj	_	_
40	=	=	JJ	JJ	_	29	dep	_	_
41	0.007	0.007	CD	CD	_	40	dobj	_	_
42	)	)	-RRB-	-RRB-	_	29	punct	_	_
43	and	and	CC	CC	_	21	cc	_	_
44	IBD	ibd	NN	NN	_	45	compound	_	_
45	patients	patient	NNS	NNS	_	21	conj	_	_
46	not	not	RB	RB	_	47	neg	_	_
47	receiving	receive	VBG	VBG	_	45	acl	_	_
48	glucocorticoid	glucocorticoid	NN	NN	_	49	compound	_	_
49	treatment	treatment	NN	NN	_	47	dobj	_	_
50	(	(	-LRB-	-LRB-	_	57	punct	_	_
51	179.7	179.7	CD	CD	_	57	compound	_	_
52	+/-	+/-	CC	CC	_	51	cc	_	_
53	171.3	171.3	CD	CD	_	51	conj	_	_
54	dpm	dpm	NN	NN	_	57	compound	_	_
55	mg-1	mg-1	NN	NN	_	57	compound	_	_
56	cytosol	cytosol	NN	NN	_	57	compound	_	_
57	protein	protein	NN	NN	_	45	dep	_	_
58	,	,	,	,	_	57	punct	_	_
59	P	p	NN	NN	_	60	nsubj	_	_
60	=	=	JJ	JJ	_	57	dep	_	_
61	0.002	0.002	CD	CD	_	60	dobj	_	_
62	)	)	-RRB-	-RRB-	_	57	punct	_	_
63	.	.	.	.	_	1	punct	_	_

1	Systemic	systemic	JJ	JJ	_	3	amod	_	_
2	hGR	hgr	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	10	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	untreated	untreated	JJ	JJ	_	7	amod	_	_
6	IBD	ibd	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	3	nmod	_	_
8	did	do	VBD	VBD	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	differ	differ	VB	VB	_	0	root	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	from	from	IN	IN	_	13	case	_	_
13	those	those	DT	DT	_	10	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	control	control	JJ	JJ	_	16	amod	_	_
16	subjects	subject	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	13	nmod	_	_
3	with	with	IN	IN	_	6	case	_	_
4	connective	connective	JJ	JJ	_	6	amod	_	_
5	tissue	tissue	NN	NN	_	6	compound	_	_
6	diseases	disease	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	13	punct	_	_
8	systemic	systemic	JJ	JJ	_	10	amod	_	_
9	hGR	hgr	NN	NN	_	10	compound	_	_
10	levels	level	NNS	NNS	_	13	nsubjpass	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	found	find	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	decreased	decrease	VBN	VBN	_	13	xcomp	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	absence	absence	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	glucocorticoid	glucocorticoid	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	Systemic	systemic	JJ	JJ	_	3	amod	_	_
2	hGR	hgr	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	27	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	patients	patient	NNS	NNS	_	3	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	Crohn	crohn	NN	NN	_	9	nmod:poss	_	_
8	's	's	POS	POS	_	9	case	_	_
9	disease	disease	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	CD	cd	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	treated	treat	VBN	VBN	_	5	acl	_	_
14	with	with	IN	IN	_	15	case	_	_
15	steroids	steroid	NNS	NNS	_	13	nmod	_	_
16	(	(	-LRB-	-LRB-	_	23	punct	_	_
17	66.6	66.6	CD	CD	_	23	compound	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	61.0	61.0	CD	CD	_	17	conj	_	_
20	dpm	dpm	NN	NN	_	23	compound	_	_
21	mg-1	mg-1	NN	NN	_	23	compound	_	_
22	cytosol	cytosol	NN	NN	_	23	compound	_	_
23	protein	protein	NN	NN	_	5	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	were	be	VBD	VBD	_	27	cop	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	different	different	JJ	JJ	_	0	root	_	_
28	from	from	IN	IN	_	29	case	_	_
29	those	those	DT	DT	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	patients	patient	NNS	NNS	_	29	nmod	_	_
32	with	with	IN	IN	_	34	case	_	_
33	ulcerative	ulcerative	JJ	JJ	_	34	amod	_	_
34	colitis	colitis	NN	NN	_	31	nmod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	UC	uc	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	(	(	-LRB-	-LRB-	_	45	punct	_	_
39	56.1	56.1	CD	CD	_	45	compound	_	_
40	+/-	+/-	CC	CC	_	39	cc	_	_
41	51.6	51.6	CD	CD	_	39	conj	_	_
42	dpm	dpm	NN	NN	_	45	compound	_	_
43	mg-1	mg-1	NN	NN	_	45	compound	_	_
44	cytosol	cytosol	NN	NN	_	45	compound	_	_
45	protein	protein	NN	NN	_	31	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	.	.	.	.	_	27	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	mucosal	mucosal	JJ	JJ	_	9	amod	_	_
8	hGR	hgr	NN	NN	_	9	compound	_	_
9	levels	level	NNS	NNS	_	12	nsubjpass	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	decreased	decrease	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	both	both	DT	DT	_	15	cc:preconj	_	_
15	steroid-treated	steroid-treated	JJ	JJ	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	18.0	18.0	CD	CD	_	15	appos	_	_
18	+/-	+/-	CC	CC	_	17	cc	_	_
19	15.5	15.5	CD	CD	_	17	conj	_	_
20	)	)	-RRB-	-RRB-	_	17	punct	_	_
21	and	and	CC	CC	_	15	cc	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	steroid-treated	steroid-treated	JJ	JJ	_	15	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	37.8	37.8	CD	CD	_	23	appos	_	_
26	+/-	+/-	CC	CC	_	25	cc	_	_
27	30.5	30.5	CD	CD	_	25	conj	_	_
28	)	)	-RRB-	-RRB-	_	25	punct	_	_
29	patients	patient	NNS	NNS	_	15	dep	_	_
30	compared	compare	VBN	VBN	_	33	case	_	_
31	with	with	IN	IN	_	33	case	_	_
32	control	control	JJ	JJ	_	33	amod	_	_
33	subjects	subject	NNS	NNS	_	12	advcl	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	125.6	125.6	CD	CD	_	33	dep	_	_
36	+/-	+/-	CC	CC	_	35	cc	_	_
37	97.1	97.1	CD	CD	_	35	conj	_	_
38	;	;	:	:	_	35	punct	_	_
39	P	p	NN	NN	_	40	nsubj	_	_
40	=	=	JJ	JJ	_	35	dep	_	_
41	0.00009	0.00009	CD	CD	_	40	dobj	_	_
42	and	and	CC	CC	_	40	cc	_	_
43	P	p	NN	NN	_	44	nsubj	_	_
44	=	=	JJ	JJ	_	40	conj	_	_
45	0.0008	0.0008	CD	CD	_	44	dobj	_	_
46	respectively	respectively	RB	RB	_	40	advmod	_	_
47	)	)	-RRB-	-RRB-	_	35	punct	_	_
48	.	.	.	.	_	12	punct	_	_

1	IL-6	il-6	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	13	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	all	all	DT	DT	_	6	det	_	_
5	IBD	ibd	NN	NN	_	6	compound	_	_
6	groups	group	NNS	NNS	_	2	nmod	_	_
7	with	with	IN	IN	_	10	nmod	_	_
8	and	and	CC	CC	_	10	cc	_	_
9	without	without	IN	IN	_	10	conj	_	_
10	steroids	steroid	NNS	NNS	_	6	nmod	_	_
11	were	be	VBD	VBD	_	13	cop	_	_
12	significantly	significantly	RB	RB	_	13	advmod	_	_
13	different	different	JJ	JJ	_	0	root	_	_
14	from	from	IN	IN	_	15	case	_	_
15	those	those	DT	DT	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	control	control	JJ	JJ	_	18	amod	_	_
18	subjects	subject	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	In	in	IN	IN	_	4	case	_	_
4	IBD	ibd	NN	NN	_	6	nmod	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	is	be	VBZ	VBZ	_	1	dep	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	difference	difference	NN	NN	_	6	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	systemic	systemic	JJ	JJ	_	12	amod	_	_
11	hGR	hgr	NN	NN	_	12	compound	_	_
12	levels	level	NNS	NNS	_	6	nmod	_	_
13	between	between	IN	IN	_	16	case	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	steroid-treated	steroid-treated	JJ	JJ	_	16	amod	_	_
16	patients	patient	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	control	control	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	6	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	spite	spite	NN	NN	_	6	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	inflammatory	inflammatory	JJ	JJ	_	25	amod	_	_
25	activity	activity	NN	NN	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	IL-6	il-6	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	1	punct	_	_

1	Mucosal	mucosal	JJ	JJ	_	3	amod	_	_
2	hGR	hgr	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	decreased	decrease	VBN	VBN	_	0	root	_	_
6	independently	independently	RB	RB	_	5	advmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	treatment	treatment	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	probably	probably	RB	RB	_	11	advmod	_	_
11	leading	lead	VBG	VBG	_	5	xcomp	_	_
12	to	to	TO	TO	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	decreased	decrease	VBN	VBN	_	15	amod	_	_
15	protection	protection	NN	NN	_	11	nmod	_	_
16	against	against	IN	IN	_	18	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	action	action	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	intestinal	intestinal	JJ	JJ	_	22	amod	_	_
22	mucosa	mucosa	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Resistance	resistance	NN	NN	_	10	nsubj	_	_
2	to	to	TO	TO	_	7	case	_	_
3	tumor	tumor	NN	NN	_	7	compound	_	_
4	necrosis	necrosis	NN	NN	_	7	compound	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	induced	induced	JJ	JJ	_	7	amod	_	_
7	apoptosis	apoptosis	NN	NN	_	1	nmod	_	_
8	in	in	FW	FW	_	7	amod	_	_
9	vitro	vitro	FW	FW	_	8	dep	_	_
10	correlates	correlate	VBZ	VBZ	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	high	high	JJ	JJ	_	14	amod	_	_
13	metastatic	metastatic	JJ	JJ	_	14	amod	_	_
14	capacity	capacity	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	cells	cell	NNS	NNS	_	14	nmod	_	_
17	in	in	FW	FW	_	16	amod	_	_
18	vivo	vivo	FW	FW	_	17	dep	_	_
19	.	.	.	.	_	10	punct	_	_

1	TNF	tnf	NN	NN	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	one	one	CD	CD	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cytokines	cytokine	NNS	NNS	_	3	nmod	_	_
7	secreted	secrete	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	system	system	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	those	those	DT	DT	_	7	det	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	17	nsubj	_	_
8	lacking	lack	VBG	VBG	_	7	acl	_	_
9	capability	capability	NN	NN	_	8	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	form	form	VB	VB	_	9	acl	_	_
12	metastatic	metastatic	JJ	JJ	_	13	amod	_	_
13	tumors	tumor	NNS	NNS	_	11	dobj	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vivo	vivo	FW	FW	_	11	advmod	_	_
16	are	be	VBP	VBP	_	17	cop	_	_
17	susceptible	susceptible	JJ	JJ	_	3	ccomp	_	_
18	to	to	TO	TO	_	21	case	_	_
19	TNF	tnf	NN	NN	_	20	nmod:npmod	_	_
20	induced	induced	JJ	JJ	_	21	amod	_	_
21	apoptosis	apoptosis	NN	NN	_	17	nmod	_	_
22	in	in	FW	FW	_	17	dep	_	_
23	vitro	vitro	FW	FW	_	22	dep	_	_
24	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	10	nsubj	_	_
5	with	with	IN	IN	_	8	case	_	_
6	high	high	JJ	JJ	_	8	amod	_	_
7	metastatic	metastatic	JJ	JJ	_	8	amod	_	_
8	potential	potential	NN	NN	_	4	nmod	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	resistant	resistant	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	case	_	_
12	TNF	tnf	NN	NN	_	10	nmod	_	_
13	in	in	FW	FW	_	12	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	same	same	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lines	line	NNS	NNS	_	8	nsubj	_	_
7	were	be	VBD	VBD	_	8	cop	_	_
8	resistant	resistant	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	cytolytic	cytolytic	JJ	JJ	_	11	amod	_	_
11	action	action	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	other	other	JJ	JJ	_	15	amod	_	_
14	cytotoxic	cytotoxic	JJ	JJ	_	15	amod	_	_
15	proteins	protein	NNS	NNS	_	11	nmod	_	_
16	secreted	secrete	VBN	VBN	_	15	acl	_	_
17	by	by	IN	IN	_	19	case	_	_
18	LAK	lak	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	TNF	tnf	NN	NN	_	6	compound	_	_
6	resistance	resistance	NN	NN	_	9	nsubj	_	_
7	in	in	FW	FW	_	6	amod	_	_
8	vitro	vitro	FW	FW	_	7	dep	_	_
9	correlates	correlate	VBZ	VBZ	_	3	ccomp	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	level	level	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	13	nmod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	16	dep	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	provide	provide	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	tool	tool	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	improve	improve	VB	VB	_	6	acl	_	_
9	current	current	JJ	JJ	_	10	amod	_	_
10	protocols	protocol	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	immunotherapy	immunotherapy	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	insights	insight	NNS	NNS	_	6	conj	_	_
15	to	to	TO	TO	_	19	mark	_	_
16	how	how	WRB	WRB	_	19	advmod	_	_
17	tumor	tumor	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	19	nsubj	_	_
19	are	be	VBP	VBP	_	14	acl	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	are	be	VBP	VBP	_	19	conj	_	_
22	not	not	RB	RB	_	21	neg	_	_
23	killed	kill	VBN	VBN	_	19	dep	_	_
24	by	by	IN	IN	_	26	case	_	_
25	LAK	lak	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	required	require	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	9	case	_	_
6	C5a-induced	c5a-induced	JJ	JJ	_	9	amod	_	_
7	interleukin-8	interleukin-8	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	mononuclear	mononuclear	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	C5a	c5a	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	potent	potent	JJ	JJ	_	6	amod	_	_
5	peptide	peptide	NN	NN	_	6	compound	_	_
6	chemoattractant	chemoattractant	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	8	punct	_	_
8	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
9	interleukin-8	interleukin-8	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	IL-8	il-8	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	secretion	secretion	NN	NN	_	8	dobj	_	_
14	from	from	IN	IN	_	18	case	_	_
15	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
16	blood	blood	NN	NN	_	18	compound	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PBMC	pbmc	NNS	NNS	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	.	.	.	.	_	8	punct	_	_

1	Experiments	experiment	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	conducted	conduct	VBN	VBN	_	4	dep	_	_
4	to	to	TO	TO	_	0	root	_	_
5	understand	understand	VB	VB	_	4	dep	_	_
6	the	the	DT	DT	_	4	dep	_	_
7	mechanisms	mechanism	NNS	NNS	_	4	dep	_	_
8	for	for	IN	IN	_	4	dep	_	_
9	C5a-induced	c5a-induced	JJ	JJ	_	4	dep	_	_
10	IL-8	il-8	NN	NN	_	4	dep	_	_
11	production	production	NN	NN	_	4	dep	_	_
12	,	,	,	,	_	4	punct	_	_
13	which	which	WDT	WDT	_	4	dep	_	_
14	was	be	VBD	VBD	_	4	dep	_	_
15	14-fold	14-fold	JJ	JJ	_	4	dep	_	_
16	greater	greater	JJR	JJR	_	4	dep	_	_
17	than	than	IN	IN	_	4	dep	_	_
18	that	that	DT	DT	_	4	dep	_	_
19	in	in	IN	IN	_	4	dep	_	_
20	unstimulated	unstimulated	JJ	JJ	_	4	dep	_	_
21	cells	cell	NNS	NNS	_	4	dep	_	_
22	by	by	IN	IN	_	4	dep	_	_
23	2	2	CD	CD	_	4	dep	_	_
24	hours	hour	NNS	NNS	_	4	dep	_	_
25	.	.	.	.	_	4	punct	_	_

1	IL-8	il-8	NN	NN	_	2	compound	_	_
2	secretion	secretion	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	accompanied	accompany	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	accumulation	accumulation	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	IL-8	il-8	NN	NN	_	9	compound	_	_
9	mRNA	mrna	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	cytosol	cytosol	NN	NN	_	6	nmod	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	by	by	IN	IN	_	16	case	_	_
15	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
16	expression	expression	NN	NN	_	6	conj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	kappaB	kappab	NN	NN	_	22	compound	_	_
20	DNA	dna	NN	NN	_	22	compound	_	_
21	binding	binding	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	16	nmod	_	_
23	within	within	IN	IN	_	25	case	_	_
24	30	30	CD	CD	_	25	nummod	_	_
25	minutes	minute	NNS	NNS	_	4	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	AP-1	ap-1	NN	NN	_	10	nsubjpass	_	_
2	but	but	CC	CC	_	1	cc	_	_
3	not	not	RB	RB	_	7	neg	_	_
4	NF-IL-6	nf-il-6	NN	NN	_	7	compound	_	_
5	DNA	dna	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	1	conj	_	_
8	was	be	VBD	VBD	_	10	auxpass	_	_
9	also	also	RB	RB	_	10	advmod	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	C5a-stimulated	c5a-stimulated	JJ	JJ	_	13	amod	_	_
13	PBMC	pbmc	NNS	NNS	_	10	nmod	_	_
14	;	;	:	:	_	10	punct	_	_
15	however	however	RB	RB	_	26	advmod	_	_
16	,	,	,	,	_	26	punct	_	_
17	its	its	PRP$	PRP$	_	19	nmod:poss	_	_
18	delayed	delay	VBN	VBN	_	19	amod	_	_
19	expression	expression	NN	NN	_	26	nsubj	_	_
20	(	(	-LRB-	-LRB-	_	24	punct	_	_
21	maximal	maximal	JJ	JJ	_	24	dep	_	_
22	at	at	IN	IN	_	24	case	_	_
23	4	4	CD	CD	_	24	nummod	_	_
24	hours	hour	NNS	NNS	_	19	nmod	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	suggested	suggest	VBD	VBD	_	10	parataxis	_	_
27	a	a	DT	DT	_	30	det	_	_
28	less	less	RBR	RBR	_	30	advmod	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	role	role	NN	NN	_	26	dobj	_	_
31	in	in	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	rapid	rapid	JJ	JJ	_	34	amod	_	_
34	production	production	NN	NN	_	26	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	IL-8	il-8	NN	NN	_	34	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	correlation	correlation	NN	NN	_	13	nsubjpass	_	_
3	between	between	IN	IN	_	7	case	_	_
4	C5a-induced	c5a-induced	JJ	JJ	_	7	amod	_	_
5	kappaB	kappab	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-8	il-8	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	in	in	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	RAW264.7	raw264.7	NN	NN	_	18	compound	_	_
17	macrophage	macrophage	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	using	use	VBG	VBG	_	13	xcomp	_	_
20	reporter	reporter	NN	NN	_	21	compound	_	_
21	genes	gene	NNS	NNS	_	19	dobj	_	_
22	directed	direct	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	kappaB	kappab	NN	NN	_	26	compound	_	_
26	sequence	sequence	NN	NN	_	22	nmod	_	_
27	from	from	IN	IN	_	28	case	_	_
28	IkappaBalpha	ikappabalpha	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	IL-8	il-8	NN	NN	_	32	compound	_	_
31	promoter	promoter	NN	NN	_	32	compound	_	_
32	regions	region	NNS	NNS	_	28	conj	_	_
33	.	.	.	.	_	13	punct	_	_

1	C5a-induced	c5a-induced	JJ	JJ	_	4	amod	_	_
2	reporter	reporter	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	abolished	abolish	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	introducing	introduce	VBG	VBG	_	6	nmod	_	_
9	mutations	mutation	NNS	NNS	_	8	dobj	_	_
10	into	into	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	kappaB	kappab	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	by	by	IN	IN	_	16	case	_	_
16	coexpression	coexpression	NN	NN	_	8	conj	_	_
17	of	of	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	dominant	dominant	JJ	JJ	_	22	amod	_	_
20	negative	negative	JJ	JJ	_	22	amod	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	22	compound	_	_
22	construct	construct	NN	NN	_	16	nmod	_	_
23	resistant	resistant	JJ	JJ	_	22	amod	_	_
24	to	to	TO	TO	_	26	case	_	_
25	agonist-induced	agonist-induced	JJ	JJ	_	26	amod	_	_
26	phosphorylation	phosphorylation	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Pertussis	pertussis	NN	NN	_	2	compound	_	_
2	toxin	toxin	NN	NN	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	ADP-ribosylates	adp-ribosylate	VBZ	VBZ	_	2	acl:relcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Gi	gi	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	dobj	_	_
9	known	know	VBN	VBN	_	8	acl	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	couple	couple	VB	VB	_	9	xcomp	_	_
12	to	to	TO	TO	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	C5a	c5a	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	produced	produce	VBD	VBD	_	0	root	_	_
18	minimal	minimal	JJ	JJ	_	19	amod	_	_
19	inhibition	inhibition	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	C5a-induced	c5a-induced	JJ	JJ	_	23	amod	_	_
22	IL-8	il-8	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	had	have	VBD	VBD	_	17	conj	_	_
26	little	little	JJ	JJ	_	27	amod	_	_
27	effect	effect	NN	NN	_	25	dobj	_	_
28	on	on	IN	IN	_	31	case	_	_
29	C5a-induced	c5a-induced	JJ	JJ	_	31	amod	_	_
30	calcium	calcium	NN	NN	_	31	compound	_	_
31	mobilization	mobilization	NN	NN	_	25	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	RAW264.7	raw264.7	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	3	ccomp	_	_
9	for	for	IN	IN	_	13	case	_	_
10	C5a-induced	c5a-induced	JJ	JJ	_	13	amod	_	_
11	IL-8	il-8	NN	NN	_	13	compound	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	that	that	IN	IN	_	19	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	response	response	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	mediated	mediate	VBN	VBN	_	8	conj	_	_
20	primarily	primarily	RB	RB	_	19	advmod	_	_
21	through	through	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	pertussis	pertussis	NN	NN	_	25	compound	_	_
24	toxin-insensitive	toxin-insensitive	JJ	JJ	_	25	amod	_	_
25	pathway	pathway	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	targeting	targeting	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	retroviral	retroviral	JJ	JJ	_	5	amod	_	_
5	vectors	vector	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	erythroblastic	erythroblastic	JJ	JJ	_	9	amod	_	_
9	progeny	progeny	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	transduced	transduce	VBN	VBN	_	14	amod	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	14	amod	_	_
13	stem	stem	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Targeted	target	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	12	nsubj	_	_
3	to	to	TO	TO	_	5	case	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	tissues	tissue	NNS	NNS	_	2	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lineages	lineage	NNS	NNS	_	5	conj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	necessary	necessary	JJ	JJ	_	12	amod	_	_
12	feature	feature	NN	NN	_	0	root	_	_
13	of	of	IN	IN	_	17	case	_	_
14	a	a	DT	DT	_	17	det	_	_
15	gene	gene	NN	NN	_	17	compound	_	_
16	therapy	therapy	NN	NN	_	17	compound	_	_
17	vector	vector	NN	NN	_	12	nmod	_	_
18	for	for	IN	IN	_	21	case	_	_
19	many	many	JJ	JJ	_	21	amod	_	_
20	clinical	clinical	JJ	JJ	_	21	amod	_	_
21	applications	application	NNS	NNS	_	12	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	such	such	JJ	JJ	_	25	case	_	_
24	as	as	IN	IN	_	23	mwe	_	_
25	correction	correction	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	27	case	_	_
27	hemoglobinopathies	hemoglobinopathy	NNS	NNS	_	25	nmod	_	_
28	or	or	CC	CC	_	27	cc	_	_
29	thalassemias	thalassemia	NNS	NNS	_	27	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	transplantation	transplantation	NN	NN	_	25	nmod	_	_
32	of	of	IN	IN	_	37	case	_	_
33	genetically	genetically	RB	RB	_	37	advmod	_	_
34	modified	modify	VBN	VBN	_	37	amod	_	_
35	hematopoietic	hematopoietic	JJ	JJ	_	37	amod	_	_
36	stem	stem	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	31	nmod	_	_
38	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	developed	develop	VBD	VBD	_	0	root	_	_
3	retroviral	retroviral	JJ	JJ	_	4	amod	_	_
4	vectors	vector	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	20	nmod	_	_
7	the	the	DT	DT	_	10	det	_	_
8	constitutive	constitutive	JJ	JJ	_	10	amod	_	_
9	viral	viral	JJ	JJ	_	10	amod	_	_
10	enhancer	enhancer	NN	NN	_	20	nsubjpass	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	U3	u3	NN	NN	_	14	compound	_	_
14	region	region	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	3'	3'	JJ	JJ	_	18	amod	_	_
18	LTR	ltr	NN	NN	_	14	nmod	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	replaced	replace	VBN	VBN	_	4	acl:relcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	an	a	DT	DT	_	24	det	_	_
23	autoregulatory	autoregulatory	JJ	JJ	_	24	amod	_	_
24	enhancer	enhancer	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	31	case	_	_
26	the	the	DT	DT	_	31	det	_	_
27	erythroid-specific	erythroid-specific	JJ	JJ	_	31	amod	_	_
28	GATA-1	gata-1	NN	NN	_	31	compound	_	_
29	transcription	transcription	NN	NN	_	31	compound	_	_
30	factor	factor	NN	NN	_	31	compound	_	_
31	gene	gene	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	replaced	replace	VBN	VBN	_	3	amod	_	_
3	enhancer	enhancer	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	propagated	propagate	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	5'	5'	JJ	JJ	_	9	amod	_	_
9	LTR	ltr	NN	NN	_	5	nmod	_	_
10	upon	upon	IN	IN	_	11	case	_	_
11	integration	integration	NN	NN	_	5	nmod	_	_
12	into	into	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	target	target	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	genome	genome	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	modified	modify	VBN	VBN	_	3	amod	_	_
3	vectors	vector	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	used	use	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	transduce	transduce	VB	VB	_	5	xcomp	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	7	dobj	_	_
12	,	,	,	,	_	11	punct	_	_
13	cord	cord	NN	NN	_	17	compound	_	_
14	blood-derived	blood-derived	JJ	JJ	_	17	amod	_	_
15	CD34(+)	cd34(+)	JJ	JJ	_	17	amod	_	_
16	stem/progenitor	stem/progenitor	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	murine	murine	JJ	JJ	_	25	amod	_	_
21	bone	bone	NN	NN	_	25	compound	_	_
22	marrow	marrow	NN	NN	_	25	compound	_	_
23	repopulating	repopulate	VBG	VBG	_	25	amod	_	_
24	stem	stem	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	11	conj	_	_
26	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	appropriate	appropriate	JJ	JJ	_	6	amod	_	_
5	reporter	reporter	NN	NN	_	6	compound	_	_
6	genes	gene	NNS	NNS	_	2	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	triangle	triangle	NN	NN	_	9	compound	_	_
9	upLNGFR	uplngfr	NN	NN	_	6	dep	_	_
10	,	,	,	,	_	9	punct	_	_
11	EGFP	egfp	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	analyzed	analyze	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	differentiated	differentiate	VBN	VBN	_	18	amod	_	_
18	progeny	progeny	NN	NN	_	14	dep	_	_
19	of	of	IN	IN	_	22	case	_	_
20	transduced	transduce	VBN	VBN	_	22	amod	_	_
21	stem	stem	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	in	in	FW	FW	_	22	amod	_	_
24	vitro	vitro	FW	FW	_	23	dep	_	_
25	,	,	,	,	_	18	punct	_	_
26	in	in	IN	IN	_	28	case	_	_
27	liquid	liquid	JJ	JJ	_	28	amod	_	_
28	culture	culture	NN	NN	_	18	conj	_	_
29	as	as	RB	RB	_	18	cc	_	_
30	well	well	RB	RB	_	29	mwe	_	_
31	as	as	IN	IN	_	29	mwe	_	_
32	in	in	IN	IN	_	34	case	_	_
33	clonogenic	clonogenic	JJ	JJ	_	34	amod	_	_
34	assay	assay	NN	NN	_	18	conj	_	_
35	,	,	,	,	_	18	punct	_	_
36	and	and	CC	CC	_	18	cc	_	_
37	in	in	FW	FW	_	38	compound	_	_
38	vivo	vivo	FW	FW	_	18	conj	_	_
39	,	,	,	,	_	14	punct	_	_
40	after	after	IN	IN	_	43	case	_	_
41	bone	bone	NN	NN	_	43	compound	_	_
42	marrow	marrow	NN	NN	_	43	compound	_	_
43	transplantation	transplantation	NN	NN	_	14	nmod	_	_
44	in	in	IN	IN	_	47	case	_	_
45	lethally	lethally	RB	RB	_	47	advmod	_	_
46	irradiated	irradiated	JJ	JJ	_	47	amod	_	_
47	mice	mouse	NNS	NNS	_	43	nmod	_	_
48	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	GATA-1	gata-1	NN	NN	_	4	compound	_	_
3	autoregulatory	autoregulatory	JJ	JJ	_	4	amod	_	_
4	enhancer	enhancer	NN	NN	_	6	nsubj	_	_
5	effectively	effectively	RB	RB	_	6	advmod	_	_
6	restricts	restrict	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	LTR-driven	ltr-driven	JJ	JJ	_	14	amod	_	_
12	proviral	proviral	JJ	JJ	_	14	amod	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	unit	unit	NN	NN	_	8	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	erythroblastic	erythroblastic	JJ	JJ	_	18	amod	_	_
18	progeny	progeny	NN	NN	_	6	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	both	both	CC	CC	_	22	cc:preconj	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	progenitors	progenitor	NNS	NNS	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	mouse-repopulating	mouse-repopulating	JJ	JJ	_	26	amod	_	_
25	stem	stem	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	conj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Packaging	packaging	NN	NN	_	20	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	viral	viral	JJ	JJ	_	4	amod	_	_
4	particles	particle	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	integration	integration	NN	NN	_	1	conj	_	_
7	into	into	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	target	target	NN	NN	_	10	compound	_	_
10	genome	genome	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	1	punct	_	_
12	and	and	CC	CC	_	1	cc	_	_
13	stability	stability	NN	NN	_	1	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	integrated	integrated	JJ	JJ	_	17	amod	_	_
17	provirus	provirus	NN	NN	_	13	nmod	_	_
18	are	be	VBP	VBP	_	20	auxpass	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	affected	affect	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	LTR	ltr	NN	NN	_	24	compound	_	_
24	modification	modification	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	Enhancer	enhancer	NN	NN	_	2	compound	_	_
2	replacement	replacement	NN	NN	_	7	nsubj	_	_
3	is	be	VBZ	VBZ	_	7	cop	_	_
4	therefore	therefore	RB	RB	_	7	advmod	_	_
5	an	a	DT	DT	_	7	det	_	_
6	effective	effective	JJ	JJ	_	7	amod	_	_
7	strategy	strategy	NN	NN	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	target	target	VB	VB	_	10	dep	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	retroviral	retroviral	JJ	JJ	_	14	amod	_	_
14	transgene	transgene	NN	NN	_	10	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	specific	specific	JJ	JJ	_	18	amod	_	_
18	progeny	progeny	NN	NN	_	10	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	transduced	transduce	VBN	VBN	_	23	amod	_	_
21	hematopoietic	hematopoietic	JJ	JJ	_	23	amod	_	_
22	stem	stem	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	essential	essential	JJ	JJ	_	3	amod	_	_
3	role	role	NN	NN	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	12	case	_	_
7	human	human	JJ	JJ	_	12	amod	_	_
8	CD34(+)	cd34(+)	JJ	JJ	_	12	amod	_	_
9	bone	bone	NN	NN	_	12	compound	_	_
10	marrow	marrow	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	survival	survival	NN	NN	_	3	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	8	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	appos	_	_
6	,	,	,	,	_	3	punct	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	important	important	JJ	JJ	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	maturation	maturation	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	human	human	JJ	JJ	_	20	amod	_	_
18	immunodeficiency	immunodeficiency	NN	NN	_	20	compound	_	_
19	virus	virus	NN	NN	_	20	compound	_	_
20	transcription	transcription	NN	NN	_	11	conj	_	_
21	and	and	CC	CC	_	8	cc	_	_
22	plays	play	VBZ	VBZ	_	8	conj	_	_
23	a	a	DT	DT	_	24	det	_	_
24	role	role	NN	NN	_	22	dobj	_	_
25	in	in	IN	IN	_	27	mark	_	_
26	alternatively	alternatively	RB	RB	_	27	advmod	_	_
27	mediating	mediate	VBG	VBG	_	22	advcl	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	protecting	protect	VBG	VBG	_	27	conj	_	_
30	against	against	IN	IN	_	31	case	_	_
31	apoptosis	apoptosis	NN	NN	_	29	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	a	a	DT	DT	_	34	det	_	_
34	variety	variety	NN	NN	_	29	nmod	_	_
35	of	of	IN	IN	_	37	case	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	types	type	NNS	NNS	_	34	nmod	_	_
38	.	.	.	.	_	8	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	16	nsubjpass	_	_
5	for	for	IN	IN	_	6	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	12	case	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	CD34(+)	cd34(+)	JJ	JJ	_	12	amod	_	_
10	bone	bone	NN	NN	_	12	compound	_	_
11	marrow	marrow	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	has	have	VBZ	VBZ	_	16	aux	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	described	describe	VBN	VBN	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	here	here	RB	RB	_	2	advmod	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	virtually	virtually	RB	RB	_	13	advmod	_	_
7	all	all	DT	DT	_	12	det	_	_
8	human	human	JJ	JJ	_	12	amod	_	_
9	CD34(+)	cd34(+)	JJ	JJ	_	12	amod	_	_
10	bone	bone	NN	NN	_	12	compound	_	_
11	marrow	marrow	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	13	nsubj	_	_
13	express	express	VBP	VBP	_	2	ccomp	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	13	dobj	_	_
15	that	that	WDT	WDT	_	18	nsubjpass	_	_
16	can	can	MD	MD	_	18	aux	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	14	acl:relcl	_	_
19	by	by	IN	IN	_	20	case	_	_
20	exposure	exposure	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	phorbol	phorbol	NN	NN	_	24	compound	_	_
23	12-myristate	12-myristate	NN	NN	_	24	compound	_	_
24	13-acetate	13-acetate	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	a	a	DT	DT	_	27	det	_	_
27	variety	variety	NN	NN	_	24	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	cytokines	cytokine	NNS	NNS	_	27	nmod	_	_
30	,	,	,	,	_	27	punct	_	_
31	eg	eg	FW	FW	_	36	dep	_	_
32	,	,	,	,	_	36	punct	_	_
33	tumor	tumor	NN	NN	_	36	compound	_	_
34	necrosis	necrosis	NN	NN	_	36	compound	_	_
35	factor	factor	NN	NN	_	36	compound	_	_
36	alpha	alpha	NN	NN	_	27	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	interleukin-3	interleukin-3	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	43	amod	_	_
42	colony-stimulating	colony-stimulating	JJ	JJ	_	43	amod	_	_
43	factor	factor	NN	NN	_	36	conj	_	_
44	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	10	nsubjpass	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	5	ccomp	_	_
11	for	for	IN	IN	_	18	case	_	_
12	human	human	JJ	JJ	_	18	amod	_	_
13	CD34(+)	cd34(+)	JJ	JJ	_	18	amod	_	_
14	bone	bone	NN	NN	_	18	compound	_	_
15	marrow	marrow	NN	NN	_	18	compound	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	clonogenic	clonogenic	JJ	JJ	_	18	amod	_	_
18	function	function	NN	NN	_	10	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	survival	survival	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	offer	offer	VBP	VBP	_	0	root	_	_
4	insight	insight	NN	NN	_	3	dobj	_	_
5	into	into	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	new	new	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	3	nmod	_	_
9	for	for	IN	IN	_	10	case	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	maintaining	maintain	VBG	VBG	_	8	acl	_	_
13	survival	survival	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	function	function	NN	NN	_	13	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	stem	stem	NN	NN	_	12	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	progenitor	progenitor	NN	NN	_	18	conj	_	_
21	cells	cell	NNS	NNS	_	18	dep	_	_
22	and	and	CC	CC	_	3	cc	_	_
23	suggest	suggest	VBP	VBP	_	3	conj	_	_
24	that	that	IN	IN	_	40	mark	_	_
25	proposed	proposed	JJ	JJ	_	26	amod	_	_
26	strategies	strategy	NNS	NNS	_	40	nsubjpass	_	_
27	involving	involve	VBG	VBG	_	26	acl	_	_
28	inhibition	inhibition	NN	NN	_	27	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	activation	activation	NN	NN	_	28	nmod	_	_
32	as	as	IN	IN	_	34	case	_	_
33	an	a	DT	DT	_	34	det	_	_
34	adjunct	adjunct	NN	NN	_	40	nmod	_	_
35	to	to	TO	TO	_	37	case	_	_
36	cancer	cancer	NN	NN	_	37	compound	_	_
37	chemotherapy	chemotherapy	NN	NN	_	34	nmod	_	_
38	should	should	MD	MD	_	40	aux	_	_
39	be	be	VB	VB	_	40	auxpass	_	_
40	approached	approach	VBN	VBN	_	23	ccomp	_	_
41	with	with	IN	IN	_	42	case	_	_
42	caution	caution	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Unicellular-unilineage	unicellular-unilineage	JJ	JJ	_	3	amod	_	_
2	erythropoietic	erythropoietic	JJ	JJ	_	3	amod	_	_
3	cultures	culture	NNS	NNS	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	analysis	analysis	NN	NN	_	3	dep	_	_
7	of	of	IN	IN	_	10	case	_	_
8	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	6	nmod	_	_
11	at	at	IN	IN	_	14	case	_	_
12	sibling	sibling	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	6	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vitro	vitro	FW	FW	_	1	dep	_	_
3	studies	study	NNS	NNS	_	10	nsubjpass	_	_
4	on	on	IN	IN	_	7	case	_	_
5	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
6	control	control	NN	NN	_	7	compound	_	_
7	mechanisms	mechanism	NNS	NNS	_	3	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	hampered	hamper	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	heterogeneity	heterogeneity	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	analyzed	analyze	VBN	VBN	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	populations	population	NNS	NNS	_	13	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	ie	ie	FW	FW	_	22	dep	_	_
21	,	,	,	,	_	22	punct	_	_
22	lack	lack	NN	NN	_	13	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	lineage	lineage	NN	NN	_	25	compound	_	_
25	specificity	specificity	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	developmental	developmental	JJ	JJ	_	29	amod	_	_
28	stage	stage	NN	NN	_	29	compound	_	_
29	homogeneity	homogeneity	NN	NN	_	25	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	progenitor/precursor	progenitor/precursor	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	22	nmod	_	_
33	growing	grow	VBG	VBG	_	32	acl	_	_
34	in	in	IN	IN	_	35	case	_	_
35	culture	culture	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	10	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	developed	develop	VBD	VBD	_	0	root	_	_
3	unicellular	unicellular	JJ	JJ	_	5	amod	_	_
4	culture	culture	NN	NN	_	5	compound	_	_
5	systems	system	NNS	NNS	_	2	dobj	_	_
6	for	for	IN	IN	_	8	case	_	_
7	unilineage	unilineage	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	purified	purify	VBN	VBN	_	13	amod	_	_
11	hematopoietic	hematopoietic	JJ	JJ	_	13	amod	_	_
12	progenitor	progenitor	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	followed	follow	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	18	case	_	_
16	daughter	daughter	NN	NN	_	18	compound	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	analysis	analysis	NN	NN	_	14	nmod	_	_
19	at	at	IN	IN	_	23	case	_	_
20	cellular	cellular	JJ	JJ	_	23	compound	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	molecular	molecular	JJ	JJ	_	20	conj	_	_
23	level	level	NN	NN	_	14	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	culture	culture	NN	NN	_	4	compound	_	_
4	system	system	NN	NN	_	18	nmod	_	_
5	reported	report	VBN	VBN	_	4	acl	_	_
6	here	here	RB	RB	_	5	advmod	_	_
7	,	,	,	,	_	18	punct	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	1	1	LS	LS	_	18	dep	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	the	the	DT	DT	_	17	det	_	_
12	growth	growth	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	GF	gf	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	stimulus	stimulus	NN	NN	_	18	nsubj	_	_
18	induces	induce	VBZ	VBZ	_	0	root	_	_
19	cord	cord	NN	NN	_	25	compound	_	_
20	blood	blood	NN	NN	_	25	compound	_	_
21	(	(	-LRB-	-LRB-	_	25	punct	_	_
22	CB	cb	NN	NN	_	25	compound	_	_
23	)	)	-RRB-	-RRB-	_	25	punct	_	_
24	progenitor	progenitor	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	18	dobj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	proliferate	proliferate	VB	VB	_	18	xcomp	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	differentiate/mature	differentiate/mature	VB	VB	_	27	conj	_	_
30	exclusively	exclusively	RB	RB	_	27	advmod	_	_
31	along	along	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	erythroid	erythroid	JJ	JJ	_	34	amod	_	_
34	lineage	lineage	NN	NN	_	27	nmod	_	_
35	;	;	:	:	_	18	punct	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	2	2	LS	LS	_	43	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	this	this	DT	DT	_	41	det	_	_
40	erythropoietic	erythropoietic	JJ	JJ	_	41	amod	_	_
41	wave	wave	NN	NN	_	43	nsubjpass	_	_
42	is	be	VBZ	VBZ	_	43	auxpass	_	_
43	characterized	characterize	VBN	VBN	_	18	parataxis	_	_
44	by	by	IN	IN	_	50	case	_	_
45	less	less	JJR	JJR	_	47	advmod	_	_
46	than	than	IN	IN	_	45	mwe	_	_
47	4	4	CD	CD	_	50	nummod	_	_
48	%	%	NN	NN	_	50	compound	_	_
49	apoptotic	apoptotic	JJ	JJ	_	50	amod	_	_
50	cells	cell	NNS	NNS	_	43	nmod	_	_
51	;	;	:	:	_	43	punct	_	_
52	(	(	-LRB-	-LRB-	_	53	punct	_	_
53	3	3	LS	LS	_	59	dep	_	_
54	)	)	-RRB-	-RRB-	_	53	punct	_	_
55	asymmetric	asymmetric	JJ	JJ	_	56	amod	_	_
56	divisions	division	NNS	NNS	_	59	nsubj	_	_
57	are	be	VBP	VBP	_	59	cop	_	_
58	virtually	virtually	RB	RB	_	59	advmod	_	_
59	absent	absent	JJ	JJ	_	18	parataxis	_	_
60	,	,	,	,	_	59	punct	_	_
61	ie	ie	FW	FW	_	59	dep	_	_
62	,	,	,	,	_	59	punct	_	_
63	nonresponsive	nonresponsive	JJ	JJ	_	65	amod	_	_
64	hematopoietic	hematopoietic	JJ	JJ	_	65	amod	_	_
65	progenitors	progenitor	NNS	NNS	_	71	nsubjpass	_	_
66	with	with	IN	IN	_	69	case	_	_
67	no	no	DT	DT	_	69	neg	_	_
68	erythropoietic	erythropoietic	JJ	JJ	_	69	amod	_	_
69	potential	potential	NN	NN	_	65	nmod	_	_
70	are	be	VBP	VBP	_	71	auxpass	_	_
71	forced	force	VBN	VBN	_	59	dep	_	_
72	into	into	IN	IN	_	73	case	_	_
73	apoptosis	apoptosis	NN	NN	_	71	nmod	_	_
74	;	;	:	:	_	59	punct	_	_
75	(	(	-LRB-	-LRB-	_	76	punct	_	_
76	4	4	LS	LS	_	83	dep	_	_
77	)	)	-RRB-	-RRB-	_	76	punct	_	_
78	the	the	DT	DT	_	79	det	_	_
79	system	system	NN	NN	_	83	nsubj	_	_
80	is	be	VBZ	VBZ	_	83	cop	_	_
81	cell	cell	NN	NN	_	83	nmod:npmod	_	_
82	division	division	NN	NN	_	83	nmod:npmod	_	_
83	controlled	controlled	JJ	JJ	_	18	parataxis	_	_
84	(	(	-LRB-	-LRB-	_	85	punct	_	_
85	cdc	cdc	NN	NN	_	83	dep	_	_
86	)	)	-RRB-	-RRB-	_	85	punct	_	_
87	,	,	,	,	_	83	punct	_	_
88	ie	ie	FW	FW	_	83	dep	_	_
89	,	,	,	,	_	83	punct	_	_
90	the	the	DT	DT	_	91	det	_	_
91	number	number	NN	NN	_	99	nsubjpass	_	_
92	of	of	IN	IN	_	93	case	_	_
93	divisions	division	NNS	NNS	_	91	nmod	_	_
94	performed	perform	VBN	VBN	_	93	acl	_	_
95	by	by	IN	IN	_	97	case	_	_
96	each	each	DT	DT	_	97	det	_	_
97	cell	cell	NN	NN	_	94	nmod	_	_
98	is	be	VBZ	VBZ	_	99	auxpass	_	_
99	monitored	monitor	VBN	VBN	_	83	parataxis	_	_
100	.	.	.	.	_	18	punct	_	_

1	Single-cell	single-cell	JJ	JJ	_	5	amod	_	_
2	reverse	reverse	NN	NN	_	5	compound	_	_
3	transcriptase-polymerase	transcriptase-polymerase	NN	NN	_	5	compound	_	_
4	chain	chain	NN	NN	_	5	compound	_	_
5	reaction	reaction	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	RT-PCR	rt-pcr	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	analysis	analysis	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	applied	apply	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	15	case	_	_
13	this	this	DT	DT	_	15	det	_	_
14	culture	culture	NN	NN	_	15	compound	_	_
15	system	system	NN	NN	_	11	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	investigate	investigate	VB	VB	_	11	xcomp	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	diverse	diverse	JJ	JJ	_	22	amod	_	_
22	receptors	receptor	NNS	NNS	_	19	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	markers	marker	NNS	NNS	_	26	compound	_	_
25	of	of	IN	IN	_	26	amod	_	_
26	differentiation	differentiation	NN	NN	_	22	conj	_	_
27	,	,	,	,	_	22	punct	_	_
28	and	and	CC	CC	_	22	cc	_	_
29	transcription	transcription	NN	NN	_	30	compound	_	_
30	factors	factor	NNS	NNS	_	22	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	EKLF	eklf	NN	NN	_	30	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	GATA-1	gata-1	NN	NN	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	GATA-2	gata-2	NN	NN	_	32	conj	_	_
37	,	,	,	,	_	32	punct	_	_
38	p45	p45	NN	NN	_	39	compound	_	_
39	NF-E2	nf-e2	NN	NN	_	32	conj	_	_
40	,	,	,	,	_	32	punct	_	_
41	PU.1	pu.1	NN	NN	_	32	conj	_	_
42	,	,	,	,	_	32	punct	_	_
43	and	and	CC	CC	_	32	cc	_	_
44	SCL/Tal1	scl/tal1	NN	NN	_	32	conj	_	_
45	)	)	-RRB-	-RRB-	_	32	punct	_	_
46	at	at	IN	IN	_	48	case	_	_
47	discrete	discrete	JJ	JJ	_	48	amod	_	_
48	stages	stage	NNS	NNS	_	17	nmod	_	_
49	of	of	IN	IN	_	51	case	_	_
50	erythropoietic	erythropoietic	JJ	JJ	_	51	amod	_	_
51	development	development	NN	NN	_	48	nmod	_	_
52	.	.	.	.	_	11	punct	_	_

1	Freshly	freshly	RB	RB	_	2	advmod	_	_
2	isolated	isolate	VBN	VBN	_	4	amod	_	_
3	CD34(+)	cd34(+)	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	expressed	express	VBD	VBD	_	0	root	_	_
6	CD34	cd34	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	c-kit	c-kit	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	PU.1	pu.1	NN	NN	_	6	conj	_	_
11	,	,	,	,	_	6	punct	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	GATA-2	gata-2	NN	NN	_	6	conj	_	_
14	but	but	CC	CC	_	5	cc	_	_
15	did	do	VBD	VBD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	express	express	VB	VB	_	5	conj	_	_
18	CD36	cd36	NN	NN	_	17	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	erythropoietin	erythropoietin	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	18	conj	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	EpoR	epor	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	,	,	,	,	_	18	punct	_	_
26	SCL/Tal1	scl/tal1	NN	NN	_	18	conj	_	_
27	,	,	,	,	_	18	punct	_	_
28	EKLF	eklf	NN	NN	_	18	conj	_	_
29	,	,	,	,	_	18	punct	_	_
30	NF-E2	nf-e2	NN	NN	_	18	conj	_	_
31	,	,	,	,	_	18	punct	_	_
32	GATA-1	gata-1	NN	NN	_	18	conj	_	_
33	,	,	,	,	_	18	punct	_	_
34	or	or	CC	CC	_	18	cc	_	_
35	glyocophorin	glyocophorin	NN	NN	_	36	compound	_	_
36	A	a	NN	NN	_	18	conj	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	GPA	gpa	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	early	early	JJ	JJ	_	10	nmod	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	intermediate	intermediate	JJ	JJ	_	10	dep	_	_
5	stages	stage	NNS	NNS	_	4	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	erythroid	erythroid	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	5	nmod	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	monitored	monitor	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	induction	induction	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CD36	cd36	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	Tal1	tal1	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	EKLF	eklf	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	NF-E2	nf-e2	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	and	and	CC	CC	_	14	cc	_	_
23	GATA-1	gata-1	NN	NN	_	14	conj	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	preceeded	preceed	VBD	VBD	_	14	acl:relcl	_	_
26	expression	expression	NN	NN	_	25	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	EpoR	epor	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	late	late	JJ	JJ	_	3	amod	_	_
3	stages	stage	NNS	NNS	_	10	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	maturation	maturation	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	GPA	gpa	NN	NN	_	10	nsubjpass	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	upregulated	upregulate	VBN	VBN	_	0	root	_	_
11	,	,	,	,	_	10	punct	_	_
12	whereas	whereas	IN	IN	_	10	dep	_	_
13	CD34	cd34	NN	NN	_	10	nsubjpass	_	_
14	,	,	,	,	_	13	punct	_	_
15	c-kit	c-kit	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	PU.1	pu.1	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	and	and	CC	CC	_	13	cc	_	_
20	GATA-2	gata-2	NN	NN	_	13	conj	_	_
21	were	be	VBD	VBD	_	25	auxpass	_	_
22	barely	barely	RB	RB	_	23	advmod	_	_
23	or	or	CC	CC	_	25	advmod	_	_
24	not	not	RB	RB	_	23	advmod	_	_
25	detected	detect	VBN	VBN	_	10	dep	_	_
26	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	competitive	competitive	JJ	JJ	_	6	amod	_	_
5	single-cell	single-cell	JJ	JJ	_	6	amod	_	_
6	RT-PCR	rt-pcr	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	assay	assay	VB	VB	_	8	xcomp	_	_
11	CD34	cd34	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	transcripts	transcript	NNS	NNS	_	10	dobj	_	_
14	in	in	IN	IN	_	18	case	_	_
15	sibling	sibling	NN	NN	_	18	compound	_	_
16	CD34(+)	cd34(+)	JJ	JJ	_	18	amod	_	_
17	CD38(-)	cd38(-)	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	differentiating	differentiate	VBG	VBG	_	18	acl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	unilineage	unilineage	JJ	JJ	_	23	amod	_	_
22	erythroid	erythroid	JJ	JJ	_	23	amod	_	_
23	cultures	culture	NNS	NNS	_	19	nmod	_	_
24	:	:	:	:	_	8	punct	_	_
25	this	this	DT	DT	_	26	det	_	_
26	analysis	analysis	NN	NN	_	27	nsubj	_	_
27	allowed	allow	VBD	VBD	_	8	parataxis	_	_
28	us	we	PRP	PRP	_	27	dobj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	semiquantitate	semiquantitate	VB	VB	_	27	xcomp	_	_
31	the	the	DT	DT	_	33	det	_	_
32	gradual	gradual	JJ	JJ	_	33	amod	_	_
33	downmodulation	downmodulation	NN	NN	_	30	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	CD34	cd34	NN	NN	_	36	compound	_	_
36	mRNA	mrna	NN	NN	_	33	nmod	_	_
37	from	from	IN	IN	_	39	case	_	_
38	progenitor	progenitor	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	33	nmod	_	_
40	through	through	IN	IN	_	44	case	_	_
41	their	they	PRP$	PRP$	_	44	nmod:poss	_	_
42	differentiating	differentiate	VBG	VBG	_	44	amod	_	_
43	erythroid	erythroid	JJ	JJ	_	44	amod	_	_
44	progeny	progeny	NN	NN	_	33	nmod	_	_
45	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	concluded	conclude	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	this	this	DT	DT	_	8	det	_	_
6	novel	novel	JJ	JJ	_	8	amod	_	_
7	culture	culture	NN	NN	_	8	compound	_	_
8	system	system	NN	NN	_	17	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	coupled	couple	VBN	VBN	_	8	acl	_	_
11	with	with	IN	IN	_	14	case	_	_
12	single-cell	single-cell	JJ	JJ	_	14	amod	_	_
13	RT-PCR	rt-pcr	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	eliminate	eliminate	VB	VB	_	3	ccomp	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ambiguities	ambiguity	NNS	NNS	_	17	dobj	_	_
20	intrinsic	intrinsic	JJ	JJ	_	19	amod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	molecular	molecular	JJ	JJ	_	23	amod	_	_
23	studies	study	NNS	NNS	_	20	nmod	_	_
24	on	on	IN	IN	_	26	case	_	_
25	heterogeneous	heterogeneous	JJ	JJ	_	26	amod	_	_
26	populations	population	NNS	NNS	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	hematopoietic	hematopoietic	JJ	JJ	_	29	amod	_	_
29	progenitors/precursors	progenitors/precursors	NNS	NNS	_	26	nmod	_	_
30	growing	grow	VBG	VBG	_	29	acl	_	_
31	in	in	IN	IN	_	32	case	_	_
32	culture	culture	NN	NN	_	30	advcl	_	_
33	,	,	,	,	_	32	punct	_	_
34	particularly	particularly	RB	RB	_	38	advmod	_	_
35	in	in	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	initial	initial	JJ	JJ	_	38	amod	_	_
38	stages	stage	NNS	NNS	_	32	nmod	_	_
39	of	of	IN	IN	_	40	case	_	_
40	development	development	NN	NN	_	38	nmod	_	_
41	.	.	.	.	_	3	punct	_	_

1	Control	control	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	cycle	cycle	NN	NN	_	5	compound	_	_
5	entry	entry	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	B	b	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
11	infected	infect	VBN	VBN	_	10	acl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	Epstein-Barr	epstein-barr	JJ	JJ	_	14	amod	_	_
14	virus	virus	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Infection	infection	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	8	case	_	_
7	Epstein-Barr	epstein-barr	JJ	JJ	_	8	amod	_	_
8	virus	virus	NN	NN	_	1	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	EBV	ebv	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	results	result	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	dep	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	cycle	cycle	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	growth	growth	NN	NN	_	18	conj	_	_
22	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	interpret	interpret	VB	VB	_	14	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanisms	mechanism	NNS	NNS	_	2	dobj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	EBV	ebv	NN	NN	_	8	nsubj	_	_
8	activates	activate	VBZ	VBZ	_	4	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	cell	cell	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	14	punct	_	_
12	we	we	PRP	PRP	_	14	nsubj	_	_
13	have	have	VBP	VBP	_	14	aux	_	_
14	assayed	assay	VBN	VBN	_	0	root	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	proteins	protein	NNS	NNS	_	14	dobj	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	19	case	_	_
19	control	control	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	G0	g0	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	G1	g1	NN	NN	_	22	conj	_	_
25	phases	phase	NNS	NNS	_	22	dep	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	cycle	cycle	NN	NN	_	22	nmod	_	_
30	and	and	CC	CC	_	19	cc	_	_
31	regulation	regulation	NN	NN	_	19	conj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	apoptosis	apoptosis	NN	NN	_	31	nmod	_	_
34	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	EBV	ebv	NN	NN	_	3	compound	_	_
3	infection	infection	NN	NN	_	18	nmod	_	_
4	most	most	JJS	JJS	_	18	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	changes	change	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	including	include	VBG	VBG	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	induction	induction	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cyclin	cyclin	NN	NN	_	15	compound	_	_
15	D2	d2	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	4	punct	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	dependent	dependent	JJ	JJ	_	0	root	_	_
19	on	on	IN	IN	_	20	case	_	_
20	expression	expression	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	EBV	ebv	NN	NN	_	23	compound	_	_
23	genes	gene	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	18	punct	_	_
25	but	but	CC	CC	_	18	cc	_	_
26	an	a	DT	DT	_	27	det	_	_
27	alteration	alteration	NN	NN	_	34	nsubj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	E2F-4	e2f-4	NN	NN	_	31	compound	_	_
31	profile	profile	NN	NN	_	27	nmod	_	_
32	was	be	VBD	VBD	_	34	cop	_	_
33	partly	partly	RB	RB	_	34	advmod	_	_
34	independent	independent	JJ	JJ	_	18	conj	_	_
35	of	of	IN	IN	_	38	case	_	_
36	viral	viral	JJ	JJ	_	38	amod	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	expression	expression	NN	NN	_	34	nmod	_	_
39	,	,	,	,	_	34	punct	_	_
40	presumably	presumably	RB	RB	_	41	advmod	_	_
41	occurring	occur	VBG	VBG	_	34	xcomp	_	_
42	in	in	IN	IN	_	43	case	_	_
43	response	response	NN	NN	_	41	nmod	_	_
44	to	to	TO	TO	_	46	case	_	_
45	signal	signal	NN	NN	_	46	compound	_	_
46	transduction	transduction	NN	NN	_	43	nmod	_	_
47	activated	activate	VBN	VBN	_	46	acl	_	_
48	when	when	WRB	WRB	_	51	advmod	_	_
49	the	the	DT	DT	_	50	det	_	_
50	virus	virus	NN	NN	_	51	nsubj	_	_
51	binds	bind	VBZ	VBZ	_	47	advcl	_	_
52	to	to	TO	TO	_	56	case	_	_
53	its	its	PRP$	PRP$	_	56	nmod:poss	_	_
54	receptor	receptor	NN	NN	_	56	compound	_	_
55	,	,	,	,	_	56	punct	_	_
56	CD21	cd21	NN	NN	_	51	nmod	_	_
57	.	.	.	.	_	18	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	comparing	compare	VBG	VBG	_	37	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	genes	gene	NNS	NNS	_	4	nmod	_	_
7	controlling	control	VBG	VBG	_	6	acl	_	_
8	apoptosis	apoptosis	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	including	include	VBG	VBG	_	11	case	_	_
11	those	those	DT	DT	_	6	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	several	several	JJ	JJ	_	14	amod	_	_
14	members	member	NNS	NNS	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	BCL-2	bcl-2	NN	NN	_	18	compound	_	_
18	family	family	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	proteins	protein	NNS	NNS	_	18	nmod	_	_
21	,	,	,	,	_	37	punct	_	_
22	the	the	DT	DT	_	25	det	_	_
23	known	known	JJ	JJ	_	25	amod	_	_
24	relative	relative	JJ	JJ	_	25	amod	_	_
25	resistance	resistance	NN	NN	_	37	nsubjpass	_	_
26	of	of	IN	IN	_	29	case	_	_
27	EBV-immortalized	ebv-immortalized	JJ	JJ	_	29	amod	_	_
28	B-cell	b-cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	25	nmod	_	_
30	to	to	TO	TO	_	31	case	_	_
31	apoptosis	apoptosis	NN	NN	_	25	nmod	_	_
32	induced	induce	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	low	low	JJ	JJ	_	35	amod	_	_
35	serum	serum	NN	NN	_	32	nmod	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	found	find	VBN	VBN	_	0	root	_	_
38	to	to	TO	TO	_	39	mark	_	_
39	correlate	correlate	VB	VB	_	37	xcomp	_	_
40	with	with	IN	IN	_	41	case	_	_
41	expression	expression	NN	NN	_	39	nmod	_	_
42	of	of	IN	IN	_	44	case	_	_
43	both	both	CC	CC	_	44	cc:preconj	_	_
44	BCL-2	bcl-2	NN	NN	_	41	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	A20	a20	NN	NN	_	44	conj	_	_
47	.	.	.	.	_	37	punct	_	_

1	A20	a20	NN	NN	_	4	nsubjpass	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	be	be	VB	VB	_	4	auxpass	_	_
4	regulated	regulate	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factor	factor	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	known	know	VBN	VBN	_	9	acl:relcl	_	_
14	to	to	TO	TO	_	16	mark	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	activated	activate	VBN	VBN	_	13	xcomp	_	_
17	by	by	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	EBV	ebv	NN	NN	_	21	compound	_	_
20	LMP-1	lmp-1	NN	NN	_	21	compound	_	_
21	protein	protein	NN	NN	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Quantitative	quantitative	JJ	JJ	_	2	amod	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	direct	direct	JJ	JJ	_	7	amod	_	_
6	temporal	temporal	JJ	JJ	_	7	amod	_	_
7	relationship	relationship	NN	NN	_	3	dobj	_	_
8	between	between	IN	IN	_	11	case	_	_
9	LMP-1	lmp-1	JJ	JJ	_	11	amod	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	active	active	JJ	JJ	_	14	amod	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	11	conj	_	_
15	during	during	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	time	time	NN	NN	_	18	compound	_	_
18	course	course	NN	NN	_	7	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	infection	infection	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Immortalization	immortalization	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD4(+)	cd4(+)	JJ	JJ	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	CD8(+)	cd8(+)	JJ	JJ	_	3	conj	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	3	dep	_	_
8	by	by	IN	IN	_	16	case	_	_
9	human	human	JJ	JJ	_	16	amod	_	_
10	T-cell	t-cell	NN	NN	_	16	compound	_	_
11	leukemia	leukemia	NN	NN	_	16	compound	_	_
12	virus	virus	NN	NN	_	16	compound	_	_
13	type	type	NN	NN	_	16	compound	_	_
14	1	1	CD	CD	_	16	nummod	_	_
15	Tax	tax	NN	NN	_	16	compound	_	_
16	mutants	mutant	NNS	NNS	_	1	nmod	_	_
17	expressed	express	VBN	VBN	_	1	acl	_	_
18	in	in	IN	IN	_	22	case	_	_
19	a	a	DT	DT	_	22	det	_	_
20	functional	functional	JJ	JJ	_	22	amod	_	_
21	molecular	molecular	JJ	JJ	_	22	amod	_	_
22	clone	clone	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	13	det	_	_
2	human	human	JJ	JJ	_	13	amod	_	_
3	T-cell	t-cell	NN	NN	_	13	compound	_	_
4	leukemia	leukemia	NN	NN	_	13	compound	_	_
5	virus	virus	NN	NN	_	13	compound	_	_
6	type	type	NN	NN	_	13	compound	_	_
7	1	1	CD	CD	_	13	nummod	_	_
8	(	(	-LRB-	-LRB-	_	13	punct	_	_
9	HTLV-1	htlv-1	NN	NN	_	13	compound	_	_
10	)	)	-RRB-	-RRB-	_	13	punct	_	_
11	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
12	trans-activator	trans-activator	NN	NN	_	13	compound	_	_
13	Tax	tax	NN	NN	_	16	nsubjpass	_	_
14	has	have	VBZ	VBZ	_	16	aux	_	_
15	been	be	VBN	VBN	_	16	auxpass	_	_
16	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	have	have	VB	VB	_	16	xcomp	_	_
19	transforming	transform	VBG	VBG	_	20	amod	_	_
20	activity	activity	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	multiple	multiple	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	culture	culture	NN	NN	_	18	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	transgenic-mouse	transgenic-mouse	JJ	JJ	_	27	amod	_	_
27	models	model	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	34	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	activating	activate	VBG	VBG	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	2	nmod	_	_
6	from	from	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	viral	viral	JJ	JJ	_	11	amod	_	_
9	long	long	JJ	JJ	_	11	amod	_	_
10	terminal	terminal	JJ	JJ	_	11	amod	_	_
11	repeat	repeat	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	LTR	ltr	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	through	through	IN	IN	_	28	case	_	_
16	the	the	DT	DT	_	28	det	_	_
17	cyclic	cyclic	JJ	JJ	_	28	amod	_	_
18	AMP	amp	NN	NN	_	28	compound	_	_
19	response	response	NN	NN	_	28	compound	_	_
20	element	element	NN	NN	_	28	compound	_	_
21	binding	binding	NN	NN	_	28	compound	_	_
22	protein/activating	protein/activating	VBG	VBG	_	28	amod	_	_
23	transcription	transcription	NN	NN	_	28	compound	_	_
24	factor	factor	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	CREB/ATF	creb/atf	NN	NN	_	28	compound	_	_
27	)	)	-RRB-	-RRB-	_	28	punct	_	_
28	family	family	NN	NN	_	5	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	transcription	transcription	NN	NN	_	31	compound	_	_
31	factors	factor	NNS	NNS	_	28	nmod	_	_
32	,	,	,	,	_	34	punct	_	_
33	Tax	tax	NN	NN	_	34	nsubj	_	_
34	activates	activate	VBZ	VBZ	_	0	root	_	_
35	the	the	DT	DT	_	36	det	_	_
36	expression	expression	NN	NN	_	34	dobj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	multiple	multiple	JJ	JJ	_	40	amod	_	_
39	cellular	cellular	JJ	JJ	_	40	amod	_	_
40	promoters	promoter	NNS	NNS	_	36	nmod	_	_
41	through	through	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	NF-kappaB	nf-kappab	NN	NN	_	44	compound	_	_
44	pathway	pathway	NN	NN	_	34	nmod	_	_
45	of	of	IN	IN	_	47	case	_	_
46	transcriptional	transcriptional	JJ	JJ	_	47	amod	_	_
47	activation	activation	NN	NN	_	44	nmod	_	_
48	.	.	.	.	_	34	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Tax	tax	NN	NN	_	3	compound	_	_
3	mutants	mutant	NNS	NNS	_	10	nsubjpass	_	_
4	M22	m22	NN	NN	_	3	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	M47	m47	NN	NN	_	4	conj	_	_
7	have	have	VBP	VBP	_	10	aux	_	_
8	previously	previously	RB	RB	_	10	advmod	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	selectively	selectively	RB	RB	_	13	advmod	_	_
13	abrogate	abrogate	VB	VB	_	10	xcomp	_	_
14	the	the	DT	DT	_	15	det	_	_
15	ability	ability	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Tax	tax	NN	NN	_	15	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	activate	activate	VB	VB	_	15	acl	_	_
20	transcription	transcription	NN	NN	_	19	dobj	_	_
21	through	through	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	dep	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	19	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	CREB/ATF	creb/atf	NN	NN	_	23	conj	_	_
26	pathway	pathway	NN	NN	_	23	dep	_	_
27	,	,	,	,	_	19	punct	_	_
28	respectively	respectively	RB	RB	_	19	advmod	_	_
29	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	mutations	mutation	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	introduced	introduce	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	tax	tax	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	ACH	ach	NN	NN	_	14	compound	_	_
12	functional	functional	JJ	JJ	_	14	amod	_	_
13	molecular	molecular	JJ	JJ	_	14	amod	_	_
14	clone	clone	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	HTLV-1	htlv-1	NN	NN	_	8	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	and	and	CC	CC	_	4	cc	_	_
19	virus	virus	NN	NN	_	27	nsubjpass	_	_
20	produced	produce	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	mutant	mutant	JJ	JJ	_	25	amod	_	_
24	ACH	ach	NN	NN	_	25	compound	_	_
25	clones	clone	NNS	NNS	_	20	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	examined	examine	VBN	VBN	_	4	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	ability	ability	NN	NN	_	27	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	replicate	replicate	VB	VB	_	30	acl	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	immortalize	immortalize	VB	VB	_	32	conj	_	_
35	primary	primary	JJ	JJ	_	37	amod	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	32	dobj	_	_
38	.	.	.	.	_	4	punct	_	_

1	While	while	IN	IN	_	11	mark	_	_
2	virus	virus	NN	NN	_	11	nsubj	_	_
3	derived	derive	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	clone	clone	NN	NN	_	3	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	M47	m47	NN	NN	_	10	compound	_	_
10	mutation	mutation	NN	NN	_	7	dobj	_	_
11	retained	retain	VBD	VBD	_	22	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	ability	ability	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	immortalize	immortalize	VB	VB	_	13	acl	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	15	dobj	_	_
18	,	,	,	,	_	22	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	M22	m22	NN	NN	_	21	compound	_	_
21	mutant	mutant	NN	NN	_	22	nsubj	_	_
22	lost	lose	VBD	VBD	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	ability	ability	NN	NN	_	22	dobj	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	immortalize	immortalize	VB	VB	_	24	acl	_	_
27	infected	infected	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	26	dobj	_	_
29	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	activation	activation	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	CREB/ATF	creb/atf	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	Tax	tax	NN	NN	_	5	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	dispensable	dispensable	JJ	JJ	_	3	ccomp	_	_
14	for	for	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	immortalization	immortalization	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	by	by	IN	IN	_	21	case	_	_
21	HTLV-1	htlv-1	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	13	punct	_	_
23	whereas	whereas	IN	IN	_	13	dep	_	_
24	activation	activation	NN	NN	_	31	nsubj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	NF-kappaB	nf-kappab	NN	NN	_	28	compound	_	_
28	pathway	pathway	NN	NN	_	24	nmod	_	_
29	may	may	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	cop	_	_
31	critical	critical	JJ	JJ	_	13	parataxis	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	oestrogen	oestrogen	NN	NN	_	6	compound	_	_
3	receptor	receptor	NN	NN	_	6	compound	_	_
4	codon	codon	NN	NN	_	6	compound	_	_
5	10	10	CD	CD	_	6	nummod	_	_
6	polymorphism	polymorphism	NN	NN	_	13	nsubj	_	_
7	detected	detect	VBN	VBN	_	6	acl	_	_
8	in	in	IN	IN	_	10	case	_	_
9	breast	breast	NN	NN	_	10	compound	_	_
10	cancer	cancer	NN	NN	_	7	nmod	_	_
11	is	be	VBZ	VBZ	_	13	cop	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	present	present	JJ	JJ	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	non-malignant	non-malignant	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	oestrogens	oestrogen	NNS	NNS	_	2	nmod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	oestrogen-receptive	oestrogen-receptive	JJ	JJ	_	7	amod	_	_
7	organs	organ	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cells	cell	NNS	NNS	_	7	conj	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	0	root	_	_
12	via	via	IN	IN	_	14	case	_	_
13	intracellular	intracellular	JJ	JJ	_	14	amod	_	_
14	receptors	receptor	NNS	NNS	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	ERalpha	eralpha	NN	NN	_	14	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	ERbeta	erbeta	NN	NN	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	.	.	.	.	_	11	punct	_	_

1	Oestrogen	oestrogen	NN	NN	_	4	compound	_	_
2	receptor	receptor	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	polymorphisms	polymorphism	NNS	NNS	_	17	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	region	region	NN	NN	_	4	nmod	_	_
8	encoding	encode	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	N-terminal	n-terminal	JJ	JJ	_	11	amod	_	_
11	portion	portion	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	protein	protein	NN	NN	_	11	nmod	_	_
15	are	be	VBP	VBP	_	17	auxpass	_	_
16	reportedly	reportedly	RB	RB	_	17	advmod	_	_
17	associated	associate	VBN	VBN	_	0	root	_	_
18	with	with	IN	IN	_	20	case	_	_
19	pathological	pathological	JJ	JJ	_	20	amod	_	_
20	conditions	condition	NNS	NNS	_	17	nmod	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	breast	breast	NN	NN	_	23	compound	_	_
23	cancer	cancer	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	hypertension	hypertension	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	spontaneous	spontaneous	JJ	JJ	_	28	amod	_	_
28	abortion	abortion	NN	NN	_	23	conj	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	coronary	coronary	JJ	JJ	_	32	amod	_	_
31	heart	heart	NN	NN	_	32	compound	_	_
32	disease	disease	NN	NN	_	23	conj	_	_
33	.	.	.	.	_	17	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	silent	silent	JJ	JJ	_	3	amod	_	_
3	mutation	mutation	NN	NN	_	35	nsubjpass	_	_
4	in	in	IN	IN	_	5	case	_	_
5	codon	codon	NN	NN	_	3	nmod	_	_
6	10	10	CD	CD	_	5	nummod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	exon	exon	NN	NN	_	5	nmod	_	_
9	1	1	CD	CD	_	8	nummod	_	_
10	,	,	,	,	_	3	punct	_	_
11	detected	detect	VBN	VBN	_	3	acl	_	_
12	in	in	IN	IN	_	13	case	_	_
13	ER-negative	er-negative	JJ	JJ	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	ER-positive	er-positive	JJ	JJ	_	13	conj	_	_
16	human	human	JJ	JJ	_	20	amod	_	_
17	breast	breast	NN	NN	_	20	compound	_	_
18	cancer	cancer	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lines	line	NNS	NNS	_	13	dep	_	_
21	,	,	,	,	_	13	punct	_	_
22	in	in	IN	IN	_	24	case	_	_
23	breast	breast	NN	NN	_	24	compound	_	_
24	tumors	tumor	NNS	NNS	_	13	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	blood	blood	NN	NN	_	27	compound	_	_
27	DNA	dna	NN	NN	_	24	conj	_	_
28	from	from	IN	IN	_	31	case	_	_
29	breast	breast	NN	NN	_	31	compound	_	_
30	cancer	cancer	NN	NN	_	31	compound	_	_
31	patients	patient	NNS	NNS	_	24	nmod	_	_
32	,	,	,	,	_	3	punct	_	_
33	has	have	VBZ	VBZ	_	35	aux	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	recognized	recognize	VBN	VBN	_	0	root	_	_
36	as	as	IN	IN	_	39	case	_	_
37	a	a	DT	DT	_	39	det	_	_
38	polymorphic	polymorphic	JJ	JJ	_	39	amod	_	_
39	site	site	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	35	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	examined	examine	VBD	VBD	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	by	by	IN	IN	_	10	case	_	_
8	denaturing	denature	VBG	VBG	_	10	amod	_	_
9	gradient-gel	gradient-gel	JJ	JJ	_	10	amod	_	_
10	electrophoresis	electrophoresis	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	sequence	sequence	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	possible	possible	JJ	JJ	_	18	amod	_	_
18	presence	presence	NN	NN	_	5	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	codon	codon	NN	NN	_	24	compound	_	_
22	10	10	CD	CD	_	24	nummod	_	_
23	polymorphic	polymorphic	JJ	JJ	_	24	amod	_	_
24	site	site	NN	NN	_	18	nmod	_	_
25	in	in	IN	IN	_	29	case	_	_
26	normal	normal	JJ	JJ	_	29	amod	_	_
27	oestrogen	oestrogen	NN	NN	_	29	compound	_	_
28	target	target	NN	NN	_	29	compound	_	_
29	organs	organ	NNS	NNS	_	18	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	cells	cell	NNS	NNS	_	29	conj	_	_
32	such	such	JJ	JJ	_	35	case	_	_
33	as	as	IN	IN	_	32	mwe	_	_
34	the	the	DT	DT	_	35	det	_	_
35	uterus	uterus	NN	NN	_	29	nmod	_	_
36	(	(	-LRB-	-LRB-	_	37	punct	_	_
37	myometrium	myometrium	NN	NN	_	35	dep	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	endometrium	endometrium	NN	NN	_	37	conj	_	_
40	)	)	-RRB-	-RRB-	_	37	punct	_	_
41	,	,	,	,	_	29	punct	_	_
42	in	in	IN	IN	_	44	case	_	_
43	the	the	DT	DT	_	44	dep	_	_
44	placenta	placenta	NN	NN	_	29	conj	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	peripheral	peripheral	JJ	JJ	_	49	amod	_	_
47	blood	blood	NN	NN	_	49	compound	_	_
48	mononuclear	mononuclear	JJ	JJ	_	49	amod	_	_
49	cells	cell	NNS	NNS	_	44	conj	_	_
50	and	and	CC	CC	_	29	cc	_	_
51	in	in	IN	IN	_	55	case	_	_
52	a	a	DT	DT	_	55	det	_	_
53	benign	benign	JJ	JJ	_	55	amod	_	_
54	uterus	uterus	NN	NN	_	55	compound	_	_
55	tumour	tumour	NN	NN	_	29	conj	_	_
56	(	(	-LRB-	-LRB-	_	57	punct	_	_
57	leiomyoma	leiomyoma	NN	NN	_	55	appos	_	_
58	)	)	-RRB-	-RRB-	_	57	punct	_	_
59	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	detected	detect	VBN	VBN	_	0	root	_	_
4	ER	er	NN	NN	_	7	compound	_	_
5	codon	codon	NN	NN	_	7	compound	_	_
6	10	10	CD	CD	_	7	nummod	_	_
7	polymorphism	polymorphism	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	these	these	DT	DT	_	10	det	_	_
10	samples	sample	NNS	NNS	_	3	nmod	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	compared	compare	VBN	VBN	_	3	conj	_	_
14	them	they	PRP	PRP	_	13	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	those	those	DT	DT	_	13	nmod	_	_
17	observed	observe	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	21	case	_	_
19	breast	breast	NN	NN	_	21	compound	_	_
20	cancer	cancer	NN	NN	_	21	compound	_	_
21	samples	sample	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	2	dep	_	_
2	tissues	tissue	NNS	NNS	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cells	cell	NNS	NNS	_	2	conj	_	_
5	studied	study	VBN	VBN	_	2	acl	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	homozygous	homozygous	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	wild-type	wild-type	JJ	JJ	_	11	amod	_	_
11	gene	gene	NN	NN	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	were	be	VBD	VBD	_	15	cop	_	_
15	heterozygous	heterozygous	JJ	JJ	_	7	conj	_	_
16	as	as	RB	RB	_	15	cc	_	_
17	well	well	RB	RB	_	16	mwe	_	_
18	as	as	IN	IN	_	16	mwe	_	_
19	homozygous	homozygous	JJ	JJ	_	15	conj	_	_
20	for	for	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	codon-10-variant	codon-10-variant	JJ	JJ	_	23	amod	_	_
23	type	type	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	codon-10-variant	codon-10-variant	JJ	JJ	_	10	amod	_	_
10	type	type	NN	NN	_	6	nmod	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	a	a	DT	DT	_	14	det	_	_
14	characteristic	characteristic	NN	NN	_	3	ccomp	_	_
15	of	of	IN	IN	_	17	case	_	_
16	breast	breast	NN	NN	_	17	compound	_	_
17	cancer	cancer	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Out	out	IN	IN	_	3	amod	_	_
2	current	current	JJ	JJ	_	3	amod	_	_
3	findings	finding	NNS	NNS	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	further	further	JJ	JJ	_	7	amod	_	_
7	investigations	investigation	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	warranted	warrant	VBN	VBN	_	4	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	elucidate	elucidate	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	possible	possible	JJ	JJ	_	14	amod	_	_
14	linkage	linkage	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	ER	er	NN	NN	_	19	compound	_	_
17	codon	codon	NN	NN	_	19	compound	_	_
18	10	10	CD	CD	_	19	nummod	_	_
19	polymorphism	polymorphism	NN	NN	_	14	nmod	_	_
20	to	to	TO	TO	_	24	case	_	_
21	physiological	physiological	JJ	JJ	_	24	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	pathological	pathological	JJ	JJ	_	21	conj	_	_
24	conditions	condition	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	reactivation	reactivation	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	8	case	_	_
4	resting	rest	VBG	VBG	_	8	amod	_	_
5	peripheral	peripheral	JJ	JJ	_	8	amod	_	_
6	blood	blood	NN	NN	_	8	compound	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	infected	infected	JJ	JJ	_	11	amod	_	_
11	adults	adult	NNS	NNS	_	8	nmod	_	_
12	upon	upon	IN	IN	_	16	case	_	_
13	in	in	FW	FW	_	16	amod	_	_
14	vitro	vitro	FW	FW	_	13	dep	_	_
15	CD4	cd4	NN	NN	_	16	compound	_	_
16	cross-linking	cross-linking	NN	NN	_	2	nmod	_	_
17	by	by	IN	IN	_	18	case	_	_
18	ligands	ligand	NNS	NNS	_	2	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	CDR2-loop	cdr2-loop	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	extracellular	extracellular	JJ	JJ	_	24	amod	_	_
24	domain	domain	NN	NN	_	2	nmod	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	.	.	.	.	_	2	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	nsubj	_	_
2	infects	infect	VBZ	VBZ	_	0	root	_	_
3	resting	rest	VBG	VBG	_	7	amod	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	dobj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PBMCs	pbmc	NNS	NNS	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	but	but	CC	CC	_	2	cc	_	_
12	remains	remain	VBZ	VBZ	_	2	conj	_	_
13	inactive	inactive	JJ	JJ	_	14	amod	_	_
14	state	state	NN	NN	_	12	xcomp	_	_
15	until	until	IN	IN	_	18	case	_	_
16	subsequent	subsequent	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	cross-linking	cross-linking	NN	NN	_	22	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	surface	surface	NN	NN	_	10	compound	_	_
10	CD4	cd4	NN	NN	_	6	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	gp120-anti-gp120	gp120-anti-gp120	NN	NN	_	14	compound	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	6	nmod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	heat-inactivated	heat-inactivated	JJ	JJ	_	17	amod	_	_
17	HIV-1	hiv-1	NN	NN	_	14	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	iHIV-1	ihiv-1	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	trigger	trigger	VB	VB	_	22	xcomp	_	_
25	activation	activation	NN	NN	_	26	compound	_	_
26	signals	signal	NNS	NNS	_	24	dobj	_	_
27	leading	lead	VBG	VBG	_	26	acl	_	_
28	to	to	TO	TO	_	30	case	_	_
29	virus	virus	NN	NN	_	30	compound	_	_
30	reactivation	reactivation	NN	NN	_	27	nmod	_	_
31	(	(	-LRB-	-LRB-	_	30	punct	_	_
32	9	9	CD	CD	_	30	nummod	_	_
33	)	)	-RRB-	-RRB-	_	30	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	20	nsubjpass	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	stimulation	stimulation	NN	NN	_	10	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	virus	virus	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	17	case	_	_
17	iHIV-1	ihiv-1	NN	NN	_	12	nmod	_	_
18	were	be	VBD	VBD	_	20	auxpass	_	_
19	strictly	strictly	RB	RB	_	20	advmod	_	_
20	linked	link	VBN	VBN	_	6	ccomp	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	concentrations	concentration	NNS	NNS	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	proteins	protein	NNS	NNS	_	23	nmod	_	_
27	used	use	VBN	VBN	_	26	acl	_	_
28	as	as	IN	IN	_	30	case	_	_
29	exogenous	exogenous	JJ	JJ	_	30	amod	_	_
30	stimuli	stimulus	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	further	further	RB	RB	_	5	advmod	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	physiologic	physiologic	JJ	JJ	_	8	amod	_	_
8	relevance	relevance	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	observations	observation	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	submitted	submit	VBN	VBN	_	17	advcl	_	_
3	to	to	TO	TO	_	8	case	_	_
4	an	a	DT	DT	_	8	det	_	_
5	in	in	FW	FW	_	8	compound	_	_
6	vitro	vitro	FW	FW	_	8	compound	_	_
7	CD4	cd4	NN	NN	_	8	compound	_	_
8	cross-linking	cross-linking	NN	NN	_	2	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	iHIV-1	ihiv-1	NN	NN	_	2	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	PBMCs	pbmc	NNS	NNS	_	17	nsubjpass	_	_
13	from	from	IN	IN	_	15	case	_	_
14	HIV-1-infected	hiv-1-infected	JJ	JJ	_	15	amod	_	_
15	patients	patient	NNS	NNS	_	12	nmod	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	produce	produce	VB	VB	_	17	xcomp	_	_
20	virus	virus	NN	NN	_	19	dobj	_	_
21	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	viral	viral	JJ	JJ	_	3	amod	_	_
3	reactivation	reactivation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	associated	associate	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	10	case	_	_
7	increased	increase	VBN	VBN	_	10	amod	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	5	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	patients	patient	NNS	NNS	_	14	nmod:poss	_	_
13	'	'	POS	POS	_	14	case	_	_
14	PBMCs	pbmc	NNS	NNS	_	10	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Additionally	additionally	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	virus	virus	NN	NN	_	4	compound	_	_
4	reactivation	reactivation	NN	NN	_	14	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	resting	rest	VBG	VBG	_	7	amod	_	_
7	PBMCs	pbmc	NNS	NNS	_	4	nmod	_	_
8	infected	infect	VBN	VBN	_	7	acl	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	HIV-1	hiv-1	NN	NN	_	8	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	18	mark	_	_
16	be	be	VB	VB	_	18	auxpass	_	_
17	specifically	specifically	RB	RB	_	18	advmod	_	_
18	induced	induce	VBN	VBN	_	14	xcomp	_	_
19	by	by	IN	IN	_	20	case	_	_
20	ligands	ligand	NNS	NNS	_	18	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	CDR2-loop	cdr2-loop	JJ	JJ	_	20	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	domain	domain	NN	NN	_	20	nmod	_	_
26	1	1	CD	CD	_	25	nummod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	D1	d1	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	of	of	IN	IN	_	31	case	_	_
31	CD4	cd4	NN	NN	_	25	nmod	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	virus	virus	NN	NN	_	34	compound	_	_
34	envelope	envelope	NN	NN	_	20	dep	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	anti-CD4	anti-cd4	JJ	JJ	_	34	conj	_	_
37	monoclonal	monoclonal	JJ	JJ	_	38	amod	_	_
38	antibodies	antibody	NNS	NNS	_	34	dep	_	_
39	)	)	-RRB-	-RRB-	_	34	punct	_	_
40	.	.	.	.	_	14	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	reactivation	reactivation	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	observed	observe	VBN	VBN	_	0	root	_	_
9	following	follow	VBG	VBG	_	11	case	_	_
10	CD4	cd4	NN	NN	_	11	compound	_	_
11	oligomerization	oligomerization	NN	NN	_	8	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	antibodies	antibody	NNS	NNS	_	11	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	bind	bind	VBP	VBP	_	13	acl:relcl	_	_
16	other	other	JJ	JJ	_	17	amod	_	_
17	epitopes	epitope	NNS	NNS	_	15	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	D1	d1	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	13	punct	_	_
21	including	include	VBG	VBG	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	D1/CDR3-loop	d1/cdr3-loop	NN	NN	_	13	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	soluble	soluble	JJ	JJ	_	4	amod	_	_
4	CD4	cd4	NN	NN	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	sCD4	scd4	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	prevented	prevent	VBD	VBD	_	0	root	_	_
9	virus	virus	NN	NN	_	10	compound	_	_
10	reactivation	reactivation	NN	NN	_	8	dobj	_	_
11	by	by	IN	IN	_	13	case	_	_
12	D1/CDR2-loop	d1/cdr2-loop	NN	NN	_	13	compound	_	_
13	ligands	ligand	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	events	event	NNS	NNS	_	19	nsubj	_	_
8	initiated	initiate	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	PBMCs	pbmc	NNS	NNS	_	8	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	oligomerization	oligomerization	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	CD4	cd4	NN	NN	_	12	nmod	_	_
15	at	at	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	D1/CDR2-loop	d1/cdr2-loop	NN	NN	_	12	nmod	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	trigger	trigger	VB	VB	_	3	ccomp	_	_
20	HIV-1	hiv-1	NN	NN	_	21	compound	_	_
21	upregulation	upregulation	NN	NN	_	19	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	infected	infected	JJ	JJ	_	24	amod	_	_
24	individuals	individual	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Bacterial	bacterial	JJ	JJ	_	2	amod	_	_
2	peptidoglycan	peptidoglycan	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	CD14-dependent	cd14-dependent	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factors	factor	NNS	NNS	_	5	nmod	_	_
9	CREB/ATF	creb/atf	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	AP-1	ap-1	NN	NN	_	9	conj	_	_
12	.	.	.	.	_	3	punct	_	_

1	Peptidoglycan	peptidoglycan	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	PGN	pgn	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	the	the	DT	DT	_	10	det	_	_
7	major	major	JJ	JJ	_	10	amod	_	_
8	cell	cell	NN	NN	_	10	compound	_	_
9	wall	wall	NN	NN	_	10	compound	_	_
10	component	component	NN	NN	_	1	appos	_	_
11	of	of	IN	IN	_	13	case	_	_
12	Gram-positive	gram-positive	JJ	JJ	_	13	amod	_	_
13	bacteria	bacterium	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	15	punct	_	_
15	induces	induce	VBZ	VBZ	_	0	root	_	_
16	secretion	secretion	NN	NN	_	15	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cytokines	cytokine	NNS	NNS	_	16	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
21	through	through	IN	IN	_	22	case	_	_
22	CD14	cd14	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	the	the	DT	DT	_	27	det	_	_
25	pattern	pattern	NN	NN	_	27	compound	_	_
26	recognition	recognition	NN	NN	_	27	compound	_	_
27	receptor	receptor	NN	NN	_	22	appos	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	binds	bind	VBZ	VBZ	_	27	acl:relcl	_	_
30	lipopolysaccharide	lipopolysaccharide	NN	NN	_	29	dobj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	other	other	JJ	JJ	_	34	amod	_	_
33	microbial	microbial	JJ	JJ	_	34	amod	_	_
34	products	product	NNS	NNS	_	30	conj	_	_
35	.	.	.	.	_	15	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	begin	begin	VB	VB	_	16	advcl	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	elucidate	elucidate	VB	VB	_	2	xcomp	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanisms	mechanism	NNS	NNS	_	4	dobj	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	regulate	regulate	VBP	VBP	_	6	acl:relcl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	transcription	transcription	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	wanted	want	VBD	VBD	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	determine	determine	VB	VB	_	16	xcomp	_	_
19	which	which	WDT	WDT	_	21	det	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	23	nsubjpass	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	activated	activate	VBN	VBN	_	18	ccomp	_	_
24	by	by	IN	IN	_	25	case	_	_
25	PGN	pgn	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	mouse	mouse	NN	NN	_	28	compound	_	_
28	RAW264.7	raw264.7	NN	NN	_	23	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	human	human	JJ	JJ	_	33	amod	_	_
31	THP-1	thp-1	NN	NN	_	33	compound	_	_
32	macrophage	macrophage	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	conj	_	_
34	.	.	.	.	_	16	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	:	:	:	:	_	10	punct	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	i	i	LS	LS	_	10	dep	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	PGN	pgn	NN	NN	_	10	nsubj	_	_
10	induced	induce	VBD	VBD	_	3	ccomp	_	_
11	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factors	factor	NNS	NNS	_	11	nmod	_	_
16	ATF-1	atf-1	NN	NN	_	15	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	CREB	creb	NN	NN	_	16	conj	_	_
19	;	;	:	:	_	10	punct	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ii	ii	LS	LS	_	26	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	ATF-1	atf-1	NN	NN	_	26	nsubj	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	CREB	creb	NN	NN	_	23	conj	_	_
26	bound	bind	VBD	VBD	_	10	dep	_	_
27	DNA	dna	NN	NN	_	26	dobj	_	_
28	as	as	IN	IN	_	30	case	_	_
29	a	a	DT	DT	_	30	det	_	_
30	dimer	dimer	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	26	cc	_	_
32	induced	induce	VBD	VBD	_	26	conj	_	_
33	transcriptional	transcriptional	JJ	JJ	_	34	amod	_	_
34	activation	activation	NN	NN	_	32	dobj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	a	a	DT	DT	_	39	det	_	_
37	CRE	cre	NN	NN	_	39	compound	_	_
38	reporter	reporter	NN	NN	_	39	compound	_	_
39	plasmid	plasmid	NN	NN	_	34	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	which	which	WDT	WDT	_	43	nsubjpass	_	_
42	was	be	VBD	VBD	_	43	auxpass	_	_
43	inhibited	inhibit	VBN	VBN	_	39	acl:relcl	_	_
44	by	by	IN	IN	_	47	case	_	_
45	dominant	dominant	JJ	JJ	_	47	amod	_	_
46	negative	negative	JJ	JJ	_	47	amod	_	_
47	CREB	creb	NN	NN	_	43	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	ATF-1	atf-1	NN	NN	_	47	conj	_	_
50	;	;	:	:	_	26	punct	_	_
51	(	(	-LRB-	-LRB-	_	52	punct	_	_
52	iii	iii	LS	LS	_	55	dep	_	_
53	)	)	-RRB-	-RRB-	_	52	punct	_	_
54	PGN	pgn	NN	NN	_	55	nsubj	_	_
55	induced	induce	VBD	VBD	_	10	dep	_	_
56	phosphorylation	phosphorylation	NN	NN	_	55	dobj	_	_
57	of	of	IN	IN	_	58	case	_	_
58	c-Jun	c-jun	NN	NN	_	56	nmod	_	_
59	,	,	,	,	_	56	punct	_	_
60	protein	protein	NN	NN	_	61	compound	_	_
61	synthesis	synthesis	NN	NN	_	56	conj	_	_
62	of	of	IN	IN	_	63	case	_	_
63	JunB	junb	NN	NN	_	61	nmod	_	_
64	and	and	CC	CC	_	63	cc	_	_
65	c-Fos	c-fos	NN	NN	_	63	conj	_	_
66	,	,	,	,	_	56	punct	_	_
67	and	and	CC	CC	_	56	cc	_	_
68	transcriptional	transcriptional	JJ	JJ	_	69	amod	_	_
69	activation	activation	NN	NN	_	56	conj	_	_
70	of	of	IN	IN	_	74	case	_	_
71	the	the	DT	DT	_	74	det	_	_
72	AP-1	ap-1	NN	NN	_	74	compound	_	_
73	reporter	reporter	NN	NN	_	74	compound	_	_
74	plasmid	plasmid	NN	NN	_	69	nmod	_	_
75	,	,	,	,	_	74	punct	_	_
76	which	which	WDT	WDT	_	78	nsubjpass	_	_
77	was	be	VBD	VBD	_	78	auxpass	_	_
78	inhibited	inhibit	VBN	VBN	_	74	acl:relcl	_	_
79	by	by	IN	IN	_	82	case	_	_
80	dominant	dominant	JJ	JJ	_	82	amod	_	_
81	negative	negative	JJ	JJ	_	82	amod	_	_
82	c-Fos	c-fos	NN	NN	_	78	nmod	_	_
83	;	;	:	:	_	55	punct	_	_
84	and	and	CC	CC	_	10	cc	_	_
85	(	(	-LRB-	-LRB-	_	86	punct	_	_
86	iv	iv	LS	LS	_	95	dep	_	_
87	)	)	-RRB-	-RRB-	_	86	punct	_	_
88	PGN-induced	pgn-induced	JJ	JJ	_	89	amod	_	_
89	activation	activation	NN	NN	_	95	nsubjpass	_	_
90	of	of	IN	IN	_	91	case	_	_
91	CREB/ATF	creb/atf	NN	NN	_	89	nmod	_	_
92	and	and	CC	CC	_	91	cc	_	_
93	AP-1	ap-1	NN	NN	_	91	conj	_	_
94	was	be	VBD	VBD	_	95	auxpass	_	_
95	mediated	mediate	VBN	VBN	_	10	conj	_	_
96	through	through	IN	IN	_	97	case	_	_
97	CD14	cd14	NN	NN	_	95	nmod	_	_
98	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	activation	activation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	14	case	_	_
10	CREB/ATF	creb/atf	NN	NN	_	14	compound	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	AP-1	ap-1	NN	NN	_	10	conj	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factors	factor	NNS	NNS	_	7	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	PGN	pgn	NN	NN	_	7	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	by	by	IN	IN	_	21	case	_	_
19	any	any	DT	DT	_	21	det	_	_
20	other	other	JJ	JJ	_	21	amod	_	_
21	component	component	NN	NN	_	16	conj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	Gram-positive	gram-positive	JJ	JJ	_	24	amod	_	_
24	bacteria	bacterium	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Defining	define	VBG	VBG	_	0	root	_	_
2	therapeutic	therapeutic	JJ	JJ	_	3	amod	_	_
3	targets	target	NNS	NNS	_	1	dobj	_	_
4	by	by	IN	IN	_	5	mark	_	_
5	using	use	VBG	VBG	_	1	advcl	_	_
6	adenovirus	adenovirus	NN	NN	_	5	dobj	_	_
7	:	:	:	:	_	1	punct	_	_
8	blocking	block	VBG	VBG	_	10	csubj	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	8	dobj	_	_
10	inhibits	inhibit	VBZ	VBZ	_	1	dep	_	_
11	both	both	CC	CC	_	15	dep	_	_
12	inflammatory	inflammatory	JJ	JJ	_	15	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	destructive	destructive	JJ	JJ	_	12	conj	_	_
15	mechanisms	mechanism	NNS	NNS	_	10	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	rheumatoid	rheumatoid	JJ	JJ	_	18	amod	_	_
18	synovium	synovium	NN	NN	_	10	nmod	_	_
19	but	but	CC	CC	_	10	cc	_	_
20	spares	spare	VBZ	VBZ	_	10	conj	_	_
21	anti-inflammatory	anti-inflammatory	JJ	JJ	_	22	amod	_	_
22	mediators	mediator	NNS	NNS	_	20	dobj	_	_
23	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	18	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	transcription	transcription	NN	NN	_	7	compound	_	_
6	factor	factor	NN	NN	_	7	compound	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	pathogenesis	pathogenesis	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	rheumatoid	rheumatoid	JJ	JJ	_	13	amod	_	_
13	arthritis	arthritis	NN	NN	_	10	nmod	_	_
14	has	have	VBZ	VBZ	_	18	aux	_	_
15	long	long	RB	RB	_	18	advmod	_	_
16	been	be	VBN	VBN	_	18	cop	_	_
17	a	a	DT	DT	_	18	det	_	_
18	subject	subject	NN	NN	_	0	root	_	_
19	of	of	IN	IN	_	20	case	_	_
20	controversy	controversy	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	used	use	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	adenoviral	adenoviral	JJ	JJ	_	5	amod	_	_
5	technique	technique	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	mark	_	_
7	blocking	block	VBG	VBG	_	5	acl	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	7	dobj	_	_
9	through	through	IN	IN	_	10	case	_	_
10	overexpression	overexpression	NN	NN	_	5	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	inhibitory	inhibitory	JJ	JJ	_	15	amod	_	_
14	subunit	subunit	NN	NN	_	15	compound	_	_
15	IkappaBalpha	ikappabalpha	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	2	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	has	have	VBZ	VBZ	_	2	dep	_	_
19	the	the	DT	DT	_	20	det	_	_
20	advantage	advantage	NN	NN	_	18	dobj	_	_
21	that	that	IN	IN	_	25	mark	_	_
22	it	it	PRP	PRP	_	25	nsubjpass	_	_
23	can	can	MD	MD	_	25	aux	_	_
24	be	be	VB	VB	_	25	auxpass	_	_
25	used	use	VBN	VBN	_	20	dep	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	diseased	diseased	JJ	JJ	_	29	amod	_	_
29	tissue	tissue	NN	NN	_	25	nmod	_	_
30	itself	itself	PRP	PRP	_	29	nmod:npmod	_	_
31	,	,	,	,	_	25	punct	_	_
32	with	with	IN	IN	_	35	case	_	_
33	&gt;	&gt;	JJR	JJR	_	34	advmod	_	_
34	90	90	CD	CD	_	35	nummod	_	_
35	%	%	NN	NN	_	25	nmod	_	_
36	of	of	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	dep	_	_
38	synovial	synovial	JJ	JJ	_	39	amod	_	_
39	macrophages	macrophage	NNS	NNS	_	35	nmod	_	_
40	,	,	,	,	_	39	punct	_	_
41	fibroblasts	fibroblast	NNS	NNS	_	39	conj	_	_
42	,	,	,	,	_	39	punct	_	_
43	and	and	CC	CC	_	39	cc	_	_
44	T	t	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	39	conj	_	_
46	infected	infect	VBN	VBN	_	45	acl	_	_
47	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	spontaneous	spontaneous	JJ	JJ	_	6	amod	_	_
6	production	production	NN	NN	_	17	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	tumor	tumor	NN	NN	_	11	compound	_	_
9	necrosis	necrosis	NN	NN	_	11	compound	_	_
10	factor	factor	NN	NN	_	11	compound	_	_
11	alpha	alpha	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	other	other	JJ	JJ	_	15	amod	_	_
14	pro-inflammatory	pro-inflammatory	JJ	JJ	_	15	amod	_	_
15	cytokines	cytokine	NNS	NNS	_	11	conj	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	2	ccomp	_	_
18	in	in	IN	IN	_	21	case	_	_
19	rheumatoid	rheumatoid	JJ	JJ	_	21	amod	_	_
20	synovial	synovial	JJ	JJ	_	21	amod	_	_
21	tissue	tissue	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	in	in	IN	IN	_	24	case	_	_
24	contrast	contrast	NN	NN	_	17	nmod	_	_
25	to	to	TO	TO	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	main	main	JJ	JJ	_	29	amod	_	_
28	anti-inflammatory	anti-inflammatory	JJ	JJ	_	29	amod	_	_
29	mediators	mediator	NNS	NNS	_	24	nmod	_	_
30	,	,	,	,	_	17	punct	_	_
31	like	like	IN	IN	_	32	case	_	_
32	IL-10	il-10	NN	NN	_	17	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	-11	-11	CD	CD	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	the	the	DT	DT	_	40	det	_	_
38	IL-1	il-1	NN	NN	_	40	compound	_	_
39	receptor	receptor	NN	NN	_	40	compound	_	_
40	antagonist	antagonist	NN	NN	_	32	conj	_	_
41	.	.	.	.	_	2	punct	_	_

1	Of	of	IN	IN	_	4	case	_	_
2	even	even	RB	RB	_	3	advmod	_	_
3	more	more	JJR	JJR	_	4	amod	_	_
4	interest	interest	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	IkappaBalpha	ikappabalpha	NN	NN	_	7	compound	_	_
7	overexpression	overexpression	NN	NN	_	8	nsubj	_	_
8	inhibited	inhibit	VBD	VBD	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	matrix	matrix	NN	NN	_	13	compound	_	_
13	metalloproteinases	metalloproteinase	NNS	NNS	_	10	nmod	_	_
14	1	1	CD	CD	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	3	3	CD	CD	_	14	conj	_	_
17	while	while	IN	IN	_	19	mark	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	affecting	affect	VBG	VBG	_	8	advcl	_	_
20	their	they	PRP$	PRP$	_	22	nmod:poss	_	_
21	tissue	tissue	NN	NN	_	22	compound	_	_
22	inhibitor	inhibitor	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	8	punct	_	_

1	Blocking	block	VBG	VBG	_	8	csubj	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	1	dobj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	rheumatoid	rheumatoid	JJ	JJ	_	6	amod	_	_
6	joint	joint	NN	NN	_	1	nmod	_	_
7	thus	thus	RB	RB	_	8	advmod	_	_
8	has	have	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	very	very	RB	RB	_	12	advmod	_	_
11	beneficial	beneficial	JJ	JJ	_	12	amod	_	_
12	profile	profile	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	reducing	reduce	VBG	VBG	_	12	dep	_	_
15	both	both	CC	CC	_	18	cc:preconj	_	_
16	the	the	DT	DT	_	18	det	_	_
17	inflammatory	inflammatory	JJ	JJ	_	18	amod	_	_
18	response	response	NN	NN	_	14	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	tissue	tissue	NN	NN	_	22	compound	_	_
22	destruction	destruction	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	adenoviral	adenoviral	JJ	JJ	_	3	amod	_	_
3	technique	technique	NN	NN	_	6	nsubj	_	_
4	described	describe	VBN	VBN	_	3	acl	_	_
5	here	here	RB	RB	_	4	advmod	_	_
6	has	have	VBZ	VBZ	_	0	root	_	_
7	widespread	widespread	JJ	JJ	_	8	amod	_	_
8	applicability	applicability	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	allowing	allow	VBG	VBG	_	6	advcl	_	_
11	rapid	rapid	JJ	JJ	_	12	amod	_	_
12	testing	testing	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effects	effect	NNS	NNS	_	12	nmod	_	_
16	of	of	IN	IN	_	17	mark	_	_
17	blocking	block	VBG	VBG	_	15	acl	_	_
18	a	a	DT	DT	_	21	det	_	_
19	potential	potential	JJ	JJ	_	21	amod	_	_
20	therapeutic	therapeutic	JJ	JJ	_	21	amod	_	_
21	target	target	NN	NN	_	17	dobj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	either	either	CC	CC	_	24	dep	_	_
24	cultures	culture	NNS	NNS	_	17	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	normal	normal	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	or	or	CC	CC	_	24	cc	_	_
29	in	in	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	diseased	diseased	JJ	JJ	_	32	amod	_	_
32	tissue	tissue	NN	NN	_	24	conj	_	_
33	itself	itself	PRP	PRP	_	32	nmod:npmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	factor-90	factor-90	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	5	case	_	_
4	activated	activate	VBN	VBN	_	5	amod	_	_
5	T-cells	t-cell	NNS	NNS	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	A	a	DT	DT	_	10	det	_	_
8	double-stranded	double-stranded	JJ	JJ	_	10	amod	_	_
9	RNA-binding	rna-binding	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	2	dep	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	substrate	substrate	NN	NN	_	10	conj	_	_
13	for	for	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	double-stranded	double-stranded	JJ	JJ	_	18	amod	_	_
16	RNA-dependent	rna-dependent	JJ	JJ	_	18	amod	_	_
17	protein	protein	NN	NN	_	18	compound	_	_
18	kinase	kinase	NN	NN	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	PKR	pkr	NN	NN	_	18	appos	_	_
21	.	.	.	.	_	2	punct	_	_

1	NFAT	nfat	NN	NN	_	3	compound	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	central	central	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	initiating	initiate	VBG	VBG	_	4	advcl	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	9	dobj	_	_
12	through	through	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	immediate-early	immediate-early	JJ	JJ	_	19	amod	_	_
17	T-cell	t-cell	NN	NN	_	19	compound	_	_
18	specific	specific	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	14	nmod	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	interleukin-2	interleukin-2	NN	NN	_	19	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	IL-2	il-2	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	4	punct	_	_

1	NFAT	nfat	NN	NN	_	3	compound	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	bind	bind	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	sequence	sequence	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-2	il-2	NN	NN	_	11	compound	_	_
11	enhancer	enhancer	NN	NN	_	7	nmod	_	_
12	known	know	VBN	VBN	_	11	amod	_	_
13	as	as	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	antigen	antigen	NN	NN	_	18	compound	_	_
16	receptor	receptor	NN	NN	_	18	compound	_	_
17	response	response	NN	NN	_	18	compound	_	_
18	element	element	NN	NN	_	12	nmod	_	_
19	2	2	CD	CD	_	18	nummod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	ARRE-2	arre-2	NN	NN	_	18	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	4	punct	_	_

1	Multiple	multiple	JJ	JJ	_	2	amod	_	_
2	proteins	protein	NNS	NNS	_	9	nsubjpass	_	_
3	exhibiting	exhibit	VBG	VBG	_	2	acl	_	_
4	ARRE-2	arre-2	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	3	dobj	_	_
7	have	have	VBP	VBP	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	isolated	isolate	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	heterodimer	heterodimer	NN	NN	_	9	nmod	_	_
14	from	from	IN	IN	_	18	case	_	_
15	stimulated	stimulate	VBN	VBN	_	18	amod	_	_
16	T-cell	t-cell	NN	NN	_	18	compound	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	extracts	extract	NNS	NNS	_	13	nmod	_	_
19	consisting	consist	VBG	VBG	_	18	acl	_	_
20	of	of	IN	IN	_	36	case	_	_
21	Mr	mr	NN	NN	_	22	nsubj	_	_
22	=	=	JJ	JJ	_	26	dep	_	_
23	90	90	CD	CD	_	24	nummod	_	_
24	000	000	CD	CD	_	22	dobj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	NF90	nf90	NN	NN	_	36	compound	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	26	cc	_	_
29	Mr	mr	NN	NN	_	30	nsubj	_	_
30	=	=	JJ	JJ	_	34	dep	_	_
31	45	45	CD	CD	_	32	nummod	_	_
32	000	000	CD	CD	_	30	dobj	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	NF45	nf45	NN	NN	_	26	conj	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	subunits	subunit	NNS	NNS	_	19	nmod	_	_
37	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	subunits	subunit	NNS	NNS	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	heterodimer	heterodimer	NN	NN	_	2	nmod	_	_
6	have	have	VBP	VBP	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	cloned	clone	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	and	and	CC	CC	_	8	cc	_	_
11	NF90	nf90	NN	NN	_	13	nsubjpass	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	found	find	VBN	VBN	_	8	conj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	encode	encode	VB	VB	_	13	xcomp	_	_
16	a	a	DT	DT	_	17	det	_	_
17	protein	protein	NN	NN	_	15	dobj	_	_
18	containing	contain	VBG	VBG	_	17	acl	_	_
19	two	two	CD	CD	_	20	nummod	_	_
20	domains	domain	NNS	NNS	_	18	dobj	_	_
21	that	that	WDT	WDT	_	23	nsubjpass	_	_
22	are	be	VBP	VBP	_	23	auxpass	_	_
23	predicted	predict	VBN	VBN	_	20	acl:relcl	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	form	form	VB	VB	_	23	xcomp	_	_
26	motifs	motif	NNS	NNS	_	25	dobj	_	_
27	capable	capable	JJ	JJ	_	26	amod	_	_
28	of	of	IN	IN	_	29	mark	_	_
29	binding	bind	VBG	VBG	_	27	advcl	_	_
30	to	to	TO	TO	_	32	case	_	_
31	double-stranded	double-stranded	JJ	JJ	_	32	amod	_	_
32	RNA	rna	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	Using	use	VBG	VBG	_	9	advcl	_	_
2	in	in	FW	FW	_	5	compound	_	_
3	vitro	vitro	FW	FW	_	5	compound	_	_
4	translated	translate	VBN	VBN	_	5	amod	_	_
5	polypeptides	polypeptide	NNS	NNS	_	1	dobj	_	_
6	,	,	,	,	_	9	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	NF90	nf90	NN	NN	_	13	nsubj	_	_
12	specifically	specifically	RB	RB	_	13	advmod	_	_
13	binds	bind	VBZ	VBZ	_	9	ccomp	_	_
14	to	to	TO	TO	_	16	case	_	_
15	double-stranded	double-stranded	JJ	JJ	_	16	amod	_	_
16	RNA	rna	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	NF90	nf90	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	double-stranded	double-stranded	JJ	JJ	_	10	amod	_	_
9	RNA-dependent	rna-dependent	JJ	JJ	_	10	amod	_	_
10	manner	manner	NN	NN	_	5	nmod	_	_
11	likely	likely	RB	RB	_	5	advcl	_	_
12	by	by	IN	IN	_	19	case	_	_
13	the	the	DT	DT	_	19	det	_	_
14	interferon-induced	interferon-induced	JJ	JJ	_	19	amod	_	_
15	,	,	,	,	_	19	punct	_	_
16	double-stranded	double-stranded	JJ	JJ	_	19	amod	_	_
17	RNA-dependent	rna-dependent	JJ	JJ	_	19	amod	_	_
18	protein	protein	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	11	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	PKR	pkr	NN	NN	_	19	appos	_	_
22	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	NF90	nf90	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	5	xcomp	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	only	only	RB	RB	_	12	cc:preconj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	T-cells	t-cell	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	but	but	CC	CC	_	12	cc	_	_
15	also	also	RB	RB	_	19	advmod	_	_
16	in	in	IN	IN	_	19	case	_	_
17	nonimmune	nonimmune	JJ	JJ	_	19	amod	_	_
18	HeLa	hela	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	12	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	HeLa	hela	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	protein	protein	NN	NN	_	10	nsubj	_	_
7	was	be	VBD	VBD	_	10	aux	_	_
8	almost	almost	RB	RB	_	9	advmod	_	_
9	exclusively	exclusively	RB	RB	_	10	advmod	_	_
10	localized	localized	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	ribosome	ribosome	NN	NN	_	16	compound	_	_
14	salt	salt	NN	NN	_	16	compound	_	_
15	wash	wash	NN	NN	_	16	compound	_	_
16	fraction	fraction	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lysates	lysate	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	Control	control	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	lymphocyte	lymphocyte	NN	NN	_	4	compound	_	_
4	development	development	NN	NN	_	1	nmod	_	_
5	by	by	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	Ikaros	ikaros	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	1	nmod	_	_
10	.	.	.	.	_	1	punct	_	_

1	Lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	differentiation	differentiation	NN	NN	_	4	nsubj	_	_
4	relies	rely	VBZ	VBZ	_	0	root	_	_
5	on	on	IN	IN	_	9	case	_	_
6	precisely	precisely	RB	RB	_	7	advmod	_	_
7	orchestrated	orchestrate	VBN	VBN	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	repression	repression	NN	NN	_	12	compound	_	_
12	events	event	NNS	NNS	_	9	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	Gene	gene	NN	NN	_	3	compound	_	_
2	targeting	targeting	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	crucial	crucial	JJ	JJ	_	7	amod	_	_
7	roles	role	NNS	NNS	_	5	dobj	_	_
8	for	for	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	transcription	transcription	NN	NN	_	11	compound	_	_
11	factors	factor	NNS	NNS	_	7	nmod	_	_
12	Ikaros	ikaros	NN	NN	_	11	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Aiolos	aiolos	NN	NN	_	12	conj	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	regulating	regulate	VBG	VBG	_	7	acl	_	_
17	multiple	multiple	JJ	JJ	_	18	amod	_	_
18	stages	stage	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	B	b	NN	NN	_	18	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	T	t	NN	NN	_	20	conj	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	development	development	NN	NN	_	20	dep	_	_
25	.	.	.	.	_	5	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	Ikaros	ikaros	NN	NN	_	8	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Aiolos	aiolos	NN	NN	_	5	conj	_	_
8	set	set	VBP	VBP	_	3	ccomp	_	_
9	B	b	NN	NN	_	13	dep	_	_
10	cell	cell	NN	NN	_	13	dep	_	_
11	antigen-receptor	antigen-receptor	NN	NN	_	13	dep	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	BCR	bcr	NN	NN	_	19	amod	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	-	-	:	:	_	13	punct	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	TCR-mediated	tcr-mediated	JJ	JJ	_	13	conj	_	_
18	signaling	signaling	NN	NN	_	19	compound	_	_
19	thresholds	threshold	NNS	NNS	_	8	dobj	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	the	the	DT	DT	_	23	det	_	_
23	molecules	molecule	NNS	NNS	_	24	nsubj	_	_
24	exist	exist	VBP	VBP	_	8	conj	_	_
25	within	within	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	in	in	IN	IN	_	30	case	_	_
29	nuclear	nuclear	JJ	JJ	_	30	amod	_	_
30	complexes	complex	NNS	NNS	_	27	nmod	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	contain	contain	VBP	VBP	_	30	acl:relcl	_	_
33	nucleosome	nucleosome	JJ	JJ	_	34	amod	_	_
34	remodeling	remodeling	NN	NN	_	32	dobj	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	histone	histone	NN	NN	_	38	compound	_	_
37	deacetylase	deacetylase	NN	NN	_	38	compound	_	_
38	activities	activity	NNS	NNS	_	34	conj	_	_
39	.	.	.	.	_	3	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	growth-regulated	growth-regulated	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	mammalian	mammalian	JJ	JJ	_	6	amod	_	_
6	MCM5	mcm5	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	MCM6	mcm6	NN	NN	_	6	conj	_	_
9	genes	gene	NNS	NNS	_	6	dep	_	_
10	mediated	mediate	VBN	VBN	_	6	acl	_	_
11	by	by	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	E2F	e2f	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Initiation	initiation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	replication	replication	NN	NN	_	1	nmod	_	_
5	requires	require	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	function	function	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	MCM	mcm	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	products	product	NNS	NNS	_	5	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	participate	participate	VBP	VBP	_	11	acl:relcl	_	_
15	in	in	IN	IN	_	16	mark	_	_
16	ensuring	ensure	VBG	VBG	_	14	advcl	_	_
17	that	that	IN	IN	_	20	mark	_	_
18	DNA	dna	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	20	nsubj	_	_
20	occurs	occur	VBZ	VBZ	_	16	ccomp	_	_
21	only	only	RB	RB	_	22	advmod	_	_
22	once	once	RB	RB	_	20	advmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	cycle	cycle	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	all	all	DT	DT	_	5	det	_	_
4	mammalian	mammalian	JJ	JJ	_	5	amod	_	_
5	genes	gene	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	MCM	mcm	NN	NN	_	9	compound	_	_
9	family	family	NN	NN	_	5	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	induced	induce	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	growth	growth	NN	NN	_	14	compound	_	_
14	stimulation	stimulation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	unlike	unlike	IN	IN	_	17	case	_	_
17	yeast	yeast	NN	NN	_	11	nmod	_	_
18	,	,	,	,	_	11	punct	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	the	the	DT	DT	_	22	det	_	_
21	mRNA	mrna	NN	NN	_	22	compound	_	_
22	levels	level	NNS	NNS	_	23	nsubj	_	_
23	peak	peak	VBP	VBP	_	11	conj	_	_
24	at	at	IN	IN	_	26	case	_	_
25	G1/S	g1/s	NN	NN	_	26	compound	_	_
26	boundary	boundary	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	examined	examine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activities	activity	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	isolated	isolate	VBN	VBN	_	15	amod	_	_
12	human	human	JJ	JJ	_	15	amod	_	_
13	MCM	mcm	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	promoters	promoter	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	MCM5	mcm5	NN	NN	_	12	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	MCM6	mcm6	NN	NN	_	5	compound	_	_
5	promoters	promoter	NNS	NNS	_	2	conj	_	_
6	with	with	IN	IN	_	7	case	_	_
7	mutation	mutation	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	E2F	e2f	NN	NN	_	11	compound	_	_
11	sites	site	NNS	NNS	_	7	nmod	_	_
12	failed	fail	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	regulation	regulation	NN	NN	_	12	nmod	_	_
16	following	follow	VBG	VBG	_	15	acl	_	_
17	serum	serum	NN	NN	_	18	compound	_	_
18	stimulation	stimulation	NN	NN	_	16	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	exogenous	exogenous	JJ	JJ	_	22	amod	_	_
21	E2F	e2f	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	identified	identify	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	novel	novel	JJ	JJ	_	9	amod	_	_
8	E2F-like	e2f-like	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	5	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	MCM6	mcm6	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	5	nmod	_	_
14	which	which	WDT	WDT	_	15	nsubj	_	_
15	cooperates	cooperate	VBZ	VBZ	_	13	acl:relcl	_	_
16	with	with	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	authentic	authentic	JJ	JJ	_	20	amod	_	_
19	E2F	e2f	NN	NN	_	20	compound	_	_
20	sites	site	NNS	NNS	_	15	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	E2F-dependent	e2f-dependent	JJ	JJ	_	23	amod	_	_
23	regulation	regulation	NN	NN	_	15	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Forced	forced	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	E2F1	e2f1	NN	NN	_	2	nmod	_	_
5	could	could	MD	MD	_	6	aux	_	_
6	induce	induce	VB	VB	_	0	root	_	_
7	expression	expression	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	all	all	DT	DT	_	10	det	_	_
10	members	member	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	endogenous	endogenous	JJ	JJ	_	15	amod	_	_
14	MCM	mcm	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	10	nmod	_	_
16	in	in	IN	IN	_	21	case	_	_
17	rat	rat	NN	NN	_	21	compound	_	_
18	embryonal	embryonal	JJ	JJ	_	21	amod	_	_
19	fibroblast	fibroblast	NN	NN	_	21	compound	_	_
20	REF52	ref52	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	6	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	23	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	growth-regulated	growth-regulated	JJ	JJ	_	7	amod	_	_
7	expression	expression	NN	NN	_	23	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	mammalian	mammalian	JJ	JJ	_	10	amod	_	_
10	MCM5	mcm5	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	MCM6	mcm6	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	10	dep	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	presumably	presumably	RB	RB	_	19	advmod	_	_
17	other	other	JJ	JJ	_	19	amod	_	_
18	MCM	mcm	NN	NN	_	19	compound	_	_
19	members	member	NNS	NNS	_	10	conj	_	_
20	,	,	,	,	_	23	punct	_	_
21	is	be	VBZ	VBZ	_	23	auxpass	_	_
22	primarily	primarily	RB	RB	_	23	advmod	_	_
23	regulated	regulate	VBN	VBN	_	3	ccomp	_	_
24	by	by	IN	IN	_	25	case	_	_
25	E2F	e2f	NN	NN	_	23	nmod	_	_
26	through	through	IN	IN	_	27	case	_	_
27	binding	binding	NN	NN	_	23	advcl	_	_
28	to	to	TO	TO	_	31	case	_	_
29	multiple	multiple	JJ	JJ	_	31	amod	_	_
30	E2F	e2f	NN	NN	_	31	compound	_	_
31	sites	site	NNS	NNS	_	27	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	promoters	promoter	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	c-Myc	c-myc	NN	NN	_	4	dep	_	_
2	and	and	CC	CC	_	4	cc	_	_
3	E1A	e1a	NN	NN	_	4	conj	_	_
4	induced	induced	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	sensitivity	sensitivity	NN	NN	_	11	nsubj	_	_
7	to	to	TO	TO	_	10	case	_	_
8	activated	activate	VBN	VBN	_	10	amod	_	_
9	NK	nk	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	involves	involve	VBZ	VBZ	_	0	root	_	_
12	cytotoxic	cytotoxic	JJ	JJ	_	13	amod	_	_
13	granules	granule	NNS	NNS	_	11	dobj	_	_
14	as	as	IN	IN	_	16	case	_	_
15	death	death	NN	NN	_	16	compound	_	_
16	effectors	effector	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	contact	contact	NN	NN	_	20	nsubj	_	_
3	of	of	IN	IN	_	9	case	_	_
4	natural	natural	JJ	JJ	_	9	amod	_	_
5	killer	killer	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	NK	nk	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	cells	cell	NNS	NNS	_	20	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	foreign	foreign	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	20	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	with	with	IN	IN	_	16	case	_	_
15	certain	certain	JJ	JJ	_	16	amod	_	_
16	virus-infected	virus-infected	JJ	JJ	_	12	conj	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	tumor	tumor	JJ	JJ	_	16	conj	_	_
19	cells	cell	NNS	NNS	_	16	dep	_	_
20	triggers	trigger	VBZ	VBZ	_	0	root	_	_
21	the	the	DT	DT	_	23	det	_	_
22	cytolytic	cytolytic	JJ	JJ	_	23	amod	_	_
23	machinery	machinery	NN	NN	_	20	dobj	_	_
24	of	of	IN	IN	_	26	case	_	_
25	NK	nk	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	20	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	triggering	triggering	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	5	case	_	_
5	exocytosis	exocytosis	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	cytotoxic	cytotoxic	JJ	JJ	_	11	amod	_	_
9	NK	nk	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	granules	granule	NNS	NNS	_	5	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	oncoproteins	oncoprotein	NNS	NNS	_	6	nsubj	_	_
3	c-Myc	c-myc	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	E1A	e1a	NN	NN	_	3	conj	_	_
6	render	render	VBP	VBP	_	0	root	_	_
7	cells	cell	NNS	NNS	_	8	nsubj	_	_
8	vulnerable	vulnerable	JJ	JJ	_	6	xcomp	_	_
9	to	to	TO	TO	_	13	case	_	_
10	NK	nk	NN	NN	_	13	compound	_	_
11	cell	cell	NN	NN	_	13	compound	_	_
12	mediated	mediated	JJ	JJ	_	13	amod	_	_
13	cytolysis	cytolysis	NN	NN	_	8	nmod	_	_
14	yet	yet	RB	RB	_	6	advmod	_	_
15	the	the	DT	DT	_	16	det	_	_
16	mechanisms	mechanism	NNS	NNS	_	22	nsubjpass	_	_
17	of	of	IN	IN	_	18	case	_	_
18	sensitization	sensitization	NN	NN	_	16	nmod	_	_
19	are	be	VBP	VBP	_	22	auxpass	_	_
20	not	not	RB	RB	_	22	neg	_	_
21	well	well	RB	RB	_	22	advmod	_	_
22	understood	understand	VBN	VBN	_	6	parataxis	_	_
23	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	18	case	_	_
2	a	a	DT	DT	_	18	det	_	_
3	model	model	NN	NN	_	18	compound	_	_
4	where	where	WRB	WRB	_	18	advmod	_	_
5	foreign	foreign	JJ	JJ	_	18	amod	_	_
6	cells	cell	NNS	NNS	_	18	compound	_	_
7	(	(	-LRB-	-LRB-	_	18	punct	_	_
8	rat	rat	NN	NN	_	18	compound	_	_
9	fibroblasts	fibroblast	NNS	NNS	_	18	compound	_	_
10	)	)	-RRB-	-RRB-	_	18	punct	_	_
11	were	be	VBD	VBD	_	18	amod	_	_
12	cocultured	coculture	VBN	VBN	_	18	amod	_	_
13	with	with	IN	IN	_	18	amod	_	_
14	human	human	JJ	JJ	_	18	amod	_	_
15	IL-2	il-2	NN	NN	_	18	compound	_	_
16	activated	activated	JJ	JJ	_	18	amod	_	_
17	NK	nk	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	21	nmod	_	_
19	,	,	,	,	_	21	punct	_	_
20	we	we	PRP	PRP	_	21	nsubj	_	_
21	observed	observe	VBD	VBD	_	0	root	_	_
22	that	that	IN	IN	_	21	dep	_	_
23	NK	nk	NN	NN	_	21	dep	_	_
24	cells	cell	NNS	NNS	_	21	dep	_	_
25	were	be	VBD	VBD	_	21	dep	_	_
26	capable	capable	JJ	JJ	_	21	dep	_	_
27	of	of	IN	IN	_	21	dep	_	_
28	efficiently	efficiently	RB	RB	_	21	advmod	_	_
29	killing	kill	VBG	VBG	_	21	dep	_	_
30	their	they	PRP$	PRP$	_	21	dep	_	_
31	targets	target	NNS	NNS	_	21	dep	_	_
32	only	only	RB	RB	_	21	advmod	_	_
33	if	if	IN	IN	_	21	dep	_	_
34	the	the	DT	DT	_	21	dep	_	_
35	cells	cell	NNS	NNS	_	21	dep	_	_
36	overexpressed	overexpress	VBD	VBD	_	21	dep	_	_
37	the	the	DT	DT	_	21	dep	_	_
38	oncogene	oncogene	NN	NN	_	21	dep	_	_
39	c-Myc	c-myc	NN	NN	_	21	dep	_	_
40	or	or	CC	CC	_	21	cc	_	_
41	E1A	e1a	NN	NN	_	21	conj	_	_
42	.	.	.	.	_	21	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	the	the	DT	DT	_	3	det	_	_
3	parental	parental	JJ	JJ	_	10	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	the	the	DT	DT	_	8	det	_	_
6	oncogene	oncogene	NN	NN	_	8	compound	_	_
7	expressing	expressing	NN	NN	_	8	compound	_	_
8	fibroblasts	fibroblast	NNS	NNS	_	3	conj	_	_
9	similarly	similarly	RB	RB	_	10	advmod	_	_
10	triggered	trigger	VBD	VBD	_	0	root	_	_
11	phosphoinositide	phosphoinositide	NN	NN	_	12	compound	_	_
12	hydrolysis	hydrolysis	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	bound	bind	VBN	VBN	_	17	amod	_	_
16	NK	nk	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	demonstrating	demonstrate	VBG	VBG	_	10	advcl	_	_
20	that	that	IN	IN	_	25	mark	_	_
21	NK	nk	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	25	nsubjpass	_	_
23	were	be	VBD	VBD	_	25	auxpass	_	_
24	cytolytically	cytolytically	RB	RB	_	25	advmod	_	_
25	activated	activate	VBN	VBN	_	19	ccomp	_	_
26	in	in	IN	IN	_	27	case	_	_
27	contact	contact	NN	NN	_	25	nmod	_	_
28	with	with	IN	IN	_	31	case	_	_
29	both	both	CC	CC	_	31	cc:preconj	_	_
30	resistant	resistant	JJ	JJ	_	31	amod	_	_
31	parental	parental	JJ	JJ	_	27	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	oncogene	oncogene	NN	NN	_	37	compound	_	_
34	expressing	expressing	NN	NN	_	37	compound	_	_
35	sensitive	sensitive	JJ	JJ	_	37	amod	_	_
36	target	target	NN	NN	_	37	compound	_	_
37	fibroblasts	fibroblast	NNS	NNS	_	31	conj	_	_
38	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	death	death	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	independent	independent	JJ	JJ	_	0	root	_	_
6	of	of	IN	IN	_	8	case	_	_
7	wild-type	wild-type	JJ	JJ	_	8	amod	_	_
8	p53	p53	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	inhibited	inhibit	VBN	VBN	_	5	conj	_	_
13	by	by	IN	IN	_	17	case	_	_
14	an	a	DT	DT	_	17	det	_	_
15	anti-apoptotic	anti-apoptotic	JJ	JJ	_	17	amod	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	EIB19K	eib19k	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provided	provide	VBD	VBD	_	0	root	_	_
4	evidence	evidence	NN	NN	_	3	dobj	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	c-Myc	c-myc	NN	NN	_	9	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	E1A	e1a	NN	NN	_	6	conj	_	_
9	activated	activate	VBD	VBD	_	4	dep	_	_
10	the	the	DT	DT	_	14	det	_	_
11	NK	nk	NN	NN	_	14	compound	_	_
12	cell	cell	NN	NN	_	14	compound	_	_
13	induced	induced	JJ	JJ	_	14	amod	_	_
14	cytolysis	cytolysis	NN	NN	_	9	dobj	_	_
15	at	at	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	post-triggering	post-triggering	JJ	JJ	_	18	amod	_	_
18	stage	stage	NN	NN	_	9	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	NK	nk	NN	NN	_	23	compound	_	_
21	cell-target	cell-target	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	interaction	interaction	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	consistence	consistence	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	the	the	DT	DT	_	9	det	_	_
5	c-Myc	c-myc	NN	NN	_	8	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	E1A	e1a	NN	NN	_	5	conj	_	_
8	overexpressing	overexpressing	NN	NN	_	9	amod	_	_
9	fibroblasts	fibroblast	NNS	NNS	_	12	nsubj	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	sensitive	sensitive	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	cytolytic	cytolytic	JJ	JJ	_	16	amod	_	_
16	effects	effect	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	isolated	isolate	VBN	VBN	_	21	amod	_	_
19	NK	nk	NN	NN	_	21	compound	_	_
20	cell-derived	cell-derived	JJ	JJ	_	21	amod	_	_
21	granules	granule	NNS	NNS	_	16	nmod	_	_
22	than	than	IN	IN	_	24	case	_	_
23	parental	parental	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	12	nmod	_	_
25	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	oncogenes	oncogene	NNS	NNS	_	6	nsubj	_	_
6	activate	activate	VBP	VBP	_	3	ccomp	_	_
7	the	the	DT	DT	_	8	det	_	_
8	cytotoxicity	cytotoxicity	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NK	nk	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	granules	granule	NNS	NNS	_	8	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	have	have	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	directing	direct	VBG	VBG	_	4	advcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	cytolytic	cytolytic	JJ	JJ	_	11	amod	_	_
11	action	action	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	NK	nk	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	towards	towards	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	virus-infected	virus-infected	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cancer	cancer	NN	NN	_	17	conj	_	_
20	cells	cell	NNS	NNS	_	8	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	growth	growth	NN	NN	_	4	compound	_	_
4	inhibition	inhibition	NN	NN	_	1	conj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	malignant	malignant	JJ	JJ	_	7	amod	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
8	after	after	IN	IN	_	9	case	_	_
9	treatment	treatment	NN	NN	_	1	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	arsenic	arsenic	JJ	JJ	_	12	amod	_	_
12	trioxide	trioxide	NN	NN	_	9	nmod	_	_
13	at	at	IN	IN	_	16	case	_	_
14	clinically	clinically	RB	RB	_	15	advmod	_	_
15	achievable	achievable	JJ	JJ	_	16	amod	_	_
16	concentrations	concentration	NNS	NNS	_	12	nmod	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	see	see	VB	VB	_	1	dep	_	_
19	comments	comment	NNS	NNS	_	18	dobj	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Arsenic	arsenic	JJ	JJ	_	4	amod	_	_
4	trioxide	trioxide	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	As2O3	as2o3	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	can	can	MD	MD	_	9	aux	_	_
9	induce	induce	VB	VB	_	1	dep	_	_
10	clinical	clinical	JJ	JJ	_	11	amod	_	_
11	remission	remission	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	acute	acute	JJ	JJ	_	17	amod	_	_
16	promyelocytic	promyelocytic	JJ	JJ	_	17	amod	_	_
17	leukemia	leukemia	NN	NN	_	13	nmod	_	_
18	via	via	IN	IN	_	19	case	_	_
19	induction	induction	NN	NN	_	9	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	differentiation	differentiation	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	programmed	program	VBN	VBN	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	death	death	NN	NN	_	21	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	apoptosis	apoptosis	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	As2O3	as2o3	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	panel	panel	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	malignant	malignant	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	determine	determine	VB	VB	_	2	advcl	_	_
15	whether	whether	IN	IN	_	24	mark	_	_
16	growth-inhibitory	growth-inhibitory	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	apoptotic	apoptotic	JJ	JJ	_	16	conj	_	_
19	effects	effect	NNS	NNS	_	24	nsubjpass	_	_
20	of	of	IN	IN	_	21	case	_	_
21	As2O3	as2o3	NN	NN	_	19	nmod	_	_
22	can	can	MD	MD	_	24	aux	_	_
23	be	be	VB	VB	_	24	auxpass	_	_
24	observed	observe	VBN	VBN	_	14	ccomp	_	_
25	in	in	IN	IN	_	27	case	_	_
26	these	these	DT	DT	_	27	det	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	at	at	IN	IN	_	31	case	_	_
29	clinically	clinically	RB	RB	_	30	advmod	_	_
30	achievable	achievable	JJ	JJ	_	31	amod	_	_
31	concentrations	concentration	NNS	NNS	_	24	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Eight	eight	CD	CD	_	7	nummod	_	_
4	malignant	malignant	JJ	JJ	_	7	amod	_	_
5	lymphocytic	lymphocytic	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	lines	line	NNS	NNS	_	18	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	primary	primary	JJ	JJ	_	10	amod	_	_
10	cultures	culture	NNS	NNS	_	7	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	lymphocytic	lymphocytic	JJ	JJ	_	13	amod	_	_
13	leukemia	leukemia	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	lymphoma	lymphoma	NN	NN	_	13	conj	_	_
16	cells	cell	NNS	NNS	_	13	dep	_	_
17	were	be	VBD	VBD	_	18	auxpass	_	_
18	treated	treat	VBN	VBN	_	1	dep	_	_
19	with	with	IN	IN	_	20	case	_	_
20	As2O3	as2o3	NN	NN	_	25	nmod	_	_
21	,	,	,	,	_	25	punct	_	_
22	with	with	IN	IN	_	25	conj	_	_
23	or	or	CC	CC	_	25	cc	_	_
24	without	without	IN	IN	_	25	conj	_	_
25	dithiothreitol	dithiothreitol	NN	NN	_	18	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	DTT	dtt	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	or	or	CC	CC	_	25	cc	_	_
30	buthionine	buthionine	NN	NN	_	31	compound	_	_
31	sulfoximine	sulfoximine	NN	NN	_	25	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	BSO	bso	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	(	(	-LRB-	-LRB-	_	37	punct	_	_
36	an	a	DT	DT	_	37	det	_	_
37	inhibitor	inhibitor	NN	NN	_	31	dep	_	_
38	of	of	IN	IN	_	40	case	_	_
39	glutathione	glutathione	NN	NN	_	40	compound	_	_
40	synthesis	synthesis	NN	NN	_	37	nmod	_	_
41	)	)	-RRB-	-RRB-	_	37	punct	_	_
42	.	.	.	.	_	1	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	assessed	assess	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	6	case	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	morphology	morphology	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	flow	flow	NN	NN	_	9	compound	_	_
9	cytometry	cytometry	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	annexin	annexin	NN	NN	_	14	compound	_	_
12	V	v	NN	NN	_	14	compound	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	level	level	NN	NN	_	6	conj	_	_
15	,	,	,	,	_	6	punct	_	_
16	and	and	CC	CC	_	6	cc	_	_
17	terminal	terminal	JJ	JJ	_	20	amod	_	_
18	deoxynucleotidyl	deoxynucleotidyl	NN	NN	_	20	compound	_	_
19	transferase	transferase	NN	NN	_	20	compound	_	_
20	labeling	labeling	NN	NN	_	6	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	fragments	fragment	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Cellular	cellular	JJ	JJ	_	2	amod	_	_
2	proliferation	proliferation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	9	case	_	_
6	5-bromo-2'-deoxyuridine	5-bromo-2'-deoxyuridine	NN	NN	_	9	compound	_	_
7	incorporation	incorporation	NN	NN	_	9	compound	_	_
8	into	into	IN	IN	_	9	amod	_	_
9	DNA	dna	NN	NN	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	flow	flow	NN	NN	_	12	compound	_	_
12	cytometry	cytometry	NN	NN	_	9	conj	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	by	by	IN	IN	_	15	case	_	_
15	use	use	NN	NN	_	9	conj	_	_
16	of	of	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	mitotic	mitotic	JJ	JJ	_	20	amod	_	_
19	arrest	arrest	NN	NN	_	20	compound	_	_
20	assay	assay	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Mitochondrial	mitochondrial	JJ	JJ	_	3	amod	_	_
2	transmembrane	transmembrane	JJ	JJ	_	3	amod	_	_
3	potential	potential	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	delta	delta	NN	NN	_	6	compound	_	_
6	psi(m)	psi(m)	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	measured	measure	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	means	means	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	rhodamine	rhodamine	NN	NN	_	15	compound	_	_
14	123	123	CD	CD	_	15	nummod	_	_
15	staining	staining	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	flow	flow	NN	NN	_	18	compound	_	_
18	cytometry	cytometry	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	9	punct	_	_

1	Protein	protein	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	assessed	assess	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	western	western	NN	NN	_	8	compound	_	_
7	blot	blot	NN	NN	_	8	compound	_	_
8	analysis	analysis	NN	NN	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	immunofluorescence	immunofluorescence	NN	NN	_	8	conj	_	_
11	.	.	.	.	_	4	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Therapeutic	therapeutic	JJ	JJ	_	4	amod	_	_
4	concentrations	concentration	NNS	NNS	_	11	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	As2O3	as2o3	NN	NN	_	4	nmod	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	1-2	1-2	CD	CD	_	9	nummod	_	_
9	microM	microm	NN	NN	_	4	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	had	have	VBD	VBD	_	20	dep	_	_
12	dual	dual	JJ	JJ	_	13	amod	_	_
13	effects	effect	NNS	NNS	_	11	dobj	_	_
14	on	on	IN	IN	_	16	case	_	_
15	malignant	malignant	JJ	JJ	_	16	amod	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
17	:	:	:	:	_	11	punct	_	_
18	1	1	LS	LS	_	20	dep	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	inhibition	inhibition	NN	NN	_	1	dep	_	_
21	of	of	IN	IN	_	22	case	_	_
22	growth	growth	NN	NN	_	20	nmod	_	_
23	through	through	IN	IN	_	29	case	_	_
24	adenosine	adenosine	NN	NN	_	29	compound	_	_
25	triphosphate	triphosphate	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	ATP	atp	NN	NN	_	29	compound	_	_
28	)	)	-RRB-	-RRB-	_	29	punct	_	_
29	depletion	depletion	NN	NN	_	20	nmod	_	_
30	and	and	CC	CC	_	20	cc	_	_
31	prolongation	prolongation	NN	NN	_	20	conj	_	_
32	of	of	IN	IN	_	35	case	_	_
33	cell	cell	NN	NN	_	35	compound	_	_
34	cycle	cycle	NN	NN	_	35	compound	_	_
35	time	time	NN	NN	_	31	nmod	_	_
36	and	and	CC	CC	_	20	cc	_	_
37	2	2	LS	LS	_	39	dep	_	_
38	)	)	-RRB-	-RRB-	_	37	punct	_	_
39	induction	induction	NN	NN	_	20	conj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	apoptosis	apoptosis	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	1	punct	_	_

1	As2O3-induced	as2o3-induced	JJ	JJ	_	2	amod	_	_
2	apoptosis	apoptosis	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	preceded	precede	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	delta	delta	NN	NN	_	8	compound	_	_
7	psi(m)	psi(m)	NN	NN	_	8	compound	_	_
8	collapse	collapse	NN	NN	_	4	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	DTT	dtt	NN	NN	_	2	nsubj	_	_
2	antagonized	antagonize	VBD	VBD	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	BSO	bso	NN	NN	_	5	nsubj	_	_
5	enhanced	enhance	VBD	VBD	_	2	conj	_	_
6	As2O3-induced	as2o3-induced	JJ	JJ	_	8	amod	_	_
7	ATP	atp	NN	NN	_	8	compound	_	_
8	depletion	depletion	NN	NN	_	2	dep	_	_
9	,	,	,	,	_	8	punct	_	_
10	delta	delta	NN	NN	_	12	compound	_	_
11	psi(m)	psi(m)	NN	NN	_	12	compound	_	_
12	collapse	collapse	NN	NN	_	8	conj	_	_
13	,	,	,	,	_	8	punct	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	apoptosis	apoptosis	NN	NN	_	8	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	Caspase-3	caspase-3	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	14	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	usually	usually	RB	RB	_	5	advmod	_	_
5	resulting	result	VBG	VBG	_	2	acl	_	_
6	from	from	IN	IN	_	9	case	_	_
7	delta	delta	NN	NN	_	9	compound	_	_
8	psi(m)	psi(m)	NN	NN	_	9	compound	_	_
9	collapse	collapse	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	2	punct	_	_
11	was	be	VBD	VBD	_	14	auxpass	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	always	always	RB	RB	_	14	advmod	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	17	case	_	_
16	As2O3-induced	as2o3-induced	JJ	JJ	_	17	amod	_	_
17	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	14	punct	_	_

1	As2O3	as2o3	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	PML	pml	NN	NN	_	9	compound	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	promyelocytic	promyelocytic	JJ	JJ	_	6	amod	_	_
6	leukemia	leukemia	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	protein	protein	NN	NN	_	9	compound	_	_
9	degradation	degradation	NN	NN	_	2	dobj	_	_
10	but	but	CC	CC	_	2	cc	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	modulate	modulate	VB	VB	_	2	conj	_	_
14	expression	expression	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	cell	cell	NN	NN	_	18	compound	_	_
17	cycle-related	cycle-related	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	c-myc	c-myc	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	retinoblastoma	retinoblastoma	NN	NN	_	24	compound	_	_
24	protein	protein	NN	NN	_	21	conj	_	_
25	,	,	,	,	_	21	punct	_	_
26	cyclin-dependent	cyclin-dependent	JJ	JJ	_	27	amod	_	_
27	kinase	kinase	NN	NN	_	21	conj	_	_
28	4	4	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	21	punct	_	_
30	cyclin	cyclin	NN	NN	_	31	compound	_	_
31	D1	d1	NN	NN	_	21	conj	_	_
32	,	,	,	,	_	21	punct	_	_
33	and	and	CC	CC	_	21	cc	_	_
34	p53	p53	NN	NN	_	21	conj	_	_
35	,	,	,	,	_	14	punct	_	_
36	or	or	CC	CC	_	14	cc	_	_
37	expression	expression	NN	NN	_	14	conj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	differentiation-related	differentiation-related	JJ	JJ	_	40	amod	_	_
40	antigens	antigen	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	2	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Substantial	substantial	JJ	JJ	_	5	amod	_	_
4	growth	growth	NN	NN	_	5	compound	_	_
5	inhibition	inhibition	NN	NN	_	13	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	apoptosis	apoptosis	NN	NN	_	5	conj	_	_
8	without	without	IN	IN	_	9	case	_	_
9	evidence	evidence	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	differentiation	differentiation	NN	NN	_	9	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	1	dep	_	_
14	in	in	IN	IN	_	18	case	_	_
15	most	most	JJS	JJS	_	18	amod	_	_
16	malignant	malignant	JJ	JJ	_	18	amod	_	_
17	lymphocytic	lymphocytic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	treated	treat	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	1-2	1-2	CD	CD	_	23	nummod	_	_
22	microM	microm	NN	NN	_	23	compound	_	_
23	As2O3	as2o3	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	As2O3	as2o3	NN	NN	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	prove	prove	VB	VB	_	0	root	_	_
4	useful	useful	JJ	JJ	_	3	xcomp	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	treatment	treatment	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	malignant	malignant	JJ	JJ	_	11	amod	_	_
10	lymphoproliferative	lymphoproliferative	JJ	JJ	_	11	amod	_	_
11	disorders	disorder	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Non-steroidal	non-steroidal	JJ	JJ	_	3	amod	_	_
2	anti-inflammatory	anti-inflammatory	JJ	JJ	_	3	amod	_	_
3	drugs	drug	NNS	NNS	_	4	nsubj	_	_
4	inhibit	inhibit	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	cytokines	cytokine	NNS	NNS	_	6	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	induce	induce	VBP	VBP	_	4	conj	_	_
11	HSP70	hsp70	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	non-steroidal	non-steroidal	JJ	JJ	_	9	amod	_	_
8	anti-inflammatory	anti-inflammatory	JJ	JJ	_	9	amod	_	_
9	drugs	drug	NNS	NNS	_	13	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	NSAIDs	nsaid	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	activate	activate	VBP	VBP	_	4	ccomp	_	_
14	heat	heat	NN	NN	_	17	compound	_	_
15	shock	shock	NN	NN	_	17	compound	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	dobj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	HSF1	hsf1	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	from	from	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	latent	latent	JJ	JJ	_	25	amod	_	_
24	cytoplasmic	cytoplasmic	JJ	JJ	_	25	amod	_	_
25	form	form	NN	NN	_	13	nmod	_	_
26	to	to	TO	TO	_	32	case	_	_
27	a	a	DT	DT	_	32	det	_	_
28	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
29	,	,	,	,	_	32	punct	_	_
30	DNA	dna	NN	NN	_	32	dep	_	_
31	binding	binding	NN	NN	_	32	compound	_	_
32	state	state	NN	NN	_	25	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	4	mark	_	_
2	HSF1	hsf1	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	function	function	NN	NN	_	28	advcl	_	_
5	as	as	IN	IN	_	8	case	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	an	a	DT	DT	_	8	det	_	_
8	activator	activator	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	heat	heat	NN	NN	_	12	compound	_	_
11	shock	shock	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	a	a	DT	DT	_	15	det	_	_
15	repressor	repressor	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	non-heat	non-heat	JJ	JJ	_	19	amod	_	_
18	shock	shock	NN	NN	_	19	compound	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	such	such	JJ	JJ	_	22	case	_	_
21	as	as	IN	IN	_	20	mwe	_	_
22	IL1B	il1b	NN	NN	_	8	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	c-fos	c-fos	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	28	punct	_	_
26	we	we	PRP	PRP	_	28	nsubj	_	_
27	have	have	VBP	VBP	_	28	aux	_	_
28	examined	examine	VBN	VBN	_	0	root	_	_
29	the	the	DT	DT	_	31	det	_	_
30	potential	potential	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	HSF1	hsf1	NN	NN	_	31	nmod	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	effects	effect	NNS	NNS	_	28	nmod	_	_
37	of	of	IN	IN	_	38	case	_	_
38	NSAIDs	nsaid	NNS	NNS	_	36	nmod	_	_
39	on	on	IN	IN	_	41	case	_	_
40	gene	gene	NN	NN	_	41	compound	_	_
41	expression	expression	NN	NN	_	36	nmod	_	_
42	in	in	IN	IN	_	48	case	_	_
43	a	a	DT	DT	_	48	det	_	_
44	human	human	JJ	JJ	_	48	amod	_	_
45	monocytic	monocytic	JJ	JJ	_	48	amod	_	_
46	cell	cell	NN	NN	_	48	compound	_	_
47	line	line	NN	NN	_	48	compound	_	_
48	THP-1	thp-1	NN	NN	_	41	nmod	_	_
49	.	.	.	.	_	28	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	two	two	CD	CD	_	5	nummod	_	_
5	members	member	NNS	NNS	_	14	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	NSAIDs	nsaid	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	sodium	sodium	NN	NN	_	11	compound	_	_
11	salicylate	salicylate	NN	NN	_	5	appos	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	sulindac	sulindac	NN	NN	_	11	conj	_	_
14	repress	repress	VBP	VBP	_	2	ccomp	_	_
15	the	the	DT	DT	_	17	det	_	_
16	IL1B	il1b	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	14	dobj	_	_
18	to	to	TO	TO	_	20	case	_	_
19	similar	similar	JJ	JJ	_	20	amod	_	_
20	degree	degree	NN	NN	_	14	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	heat	heat	NN	NN	_	23	compound	_	_
23	shock	shock	NN	NN	_	20	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	HSF1	hsf1	NN	NN	_	26	compound	_	_
26	overexpression	overexpression	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	sodium	sodium	NN	NN	_	5	compound	_	_
5	salicylate	salicylate	NN	NN	_	16	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	additional	additional	JJ	JJ	_	8	amod	_	_
8	NSAIDs	nsaid	NNS	NNS	_	5	conj	_	_
9	used	use	VBN	VBN	_	5	acl	_	_
10	at	at	IN	IN	_	11	case	_	_
11	concentrations	concentration	NNS	NNS	_	9	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	activate	activate	VBP	VBP	_	11	acl:relcl	_	_
14	HSF1	hsf1	NN	NN	_	13	dobj	_	_
15	also	also	RB	RB	_	16	advmod	_	_
16	inhibited	inhibit	VBD	VBD	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	other	other	JJ	JJ	_	22	amod	_	_
21	monocytic	monocytic	JJ	JJ	_	22	amod	_	_
22	genes	gene	NNS	NNS	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	22	dep	_	_
25	,	,	,	,	_	24	punct	_	_
26	IL-1beta	il-1beta	NN	NN	_	24	appos	_	_
27	,	,	,	,	_	24	punct	_	_
28	IL-6	il-6	NN	NN	_	24	appos	_	_
29	,	,	,	,	_	24	punct	_	_
30	IL-8	il-8	NN	NN	_	24	appos	_	_
31	,	,	,	,	_	24	punct	_	_
32	IL-10	il-10	NN	NN	_	24	appos	_	_
33	,	,	,	,	_	24	punct	_	_
34	ICAM-1	icam-1	NN	NN	_	24	appos	_	_
35	)	)	-RRB-	-RRB-	_	24	punct	_	_
36	activated	activate	VBN	VBN	_	22	acl	_	_
37	by	by	IN	IN	_	38	case	_	_
38	exposure	exposure	NN	NN	_	36	nmod	_	_
39	to	to	TO	TO	_	42	case	_	_
40	a	a	DT	DT	_	42	det	_	_
41	pro-inflammatory	pro-inflammatory	JJ	JJ	_	42	amod	_	_
42	stimulus	stimulus	NN	NN	_	38	nmod	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	lipopolysaccharide	lipopolysaccharide	NN	NN	_	42	dep	_	_
45	,	,	,	,	_	44	punct	_	_
46	LPS	lps	NN	NN	_	44	appos	_	_
47	)	)	-RRB-	-RRB-	_	44	punct	_	_
48	.	.	.	.	_	16	punct	_	_

1	At	at	IN	IN	_	14	advcl	_	_
2	least	least	JJS	JJS	_	1	mwe	_	_
3	in	in	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	case	case	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL1B	il1b	NN	NN	_	9	compound	_	_
9	promoter	promoter	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	repression	repression	NN	NN	_	14	nsubj	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	seem	seem	VB	VB	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	involve	involve	VB	VB	_	14	xcomp	_	_
17	another	another	DT	DT	_	18	det	_	_
18	factor	factor	NN	NN	_	16	dobj	_	_
19	whose	whose	WP$	WP$	_	20	nmod:poss	_	_
20	activity	activity	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	affected	affect	VBN	VBN	_	18	acl:relcl	_	_
23	by	by	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	NSAIDs	nsaid	NNS	NNS	_	22	nmod	_	_
26	,	,	,	,	_	14	punct	_	_
27	NFkappaB	nfkappab	NN	NN	_	40	nsubj	_	_
28	as	as	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	IL1B	il1b	NN	NN	_	32	compound	_	_
31	promoter	promoter	NN	NN	_	32	compound	_	_
32	fragment	fragment	NN	NN	_	27	nmod	_	_
33	used	use	VBN	VBN	_	27	acl	_	_
34	in	in	IN	IN	_	36	case	_	_
35	our	we	PRP$	PRP$	_	36	nmod:poss	_	_
36	studies	study	NNS	NNS	_	33	nmod	_	_
37	is	be	VBZ	VBZ	_	40	cop	_	_
38	not	not	RB	RB	_	40	neg	_	_
39	NFkappaB	nfkappab	NN	NN	_	40	nmod:npmod	_	_
40	responsive	responsive	JJ	JJ	_	14	parataxis	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	binds	bind	VBZ	VBZ	_	40	conj	_	_
43	specifically	specifically	RB	RB	_	42	advmod	_	_
44	to	to	TO	TO	_	45	case	_	_
45	HSF1	hsf1	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	14	punct	_	_

1	Exposure	exposure	NN	NN	_	4	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	NSAIDs	nsaid	NNS	NNS	_	1	nmod	_	_
4	had	have	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	complex	complex	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	4	dobj	_	_
8	on	on	IN	IN	_	11	case	_	_
9	HSP	hsp	NN	NN	_	11	compound	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	while	while	IN	IN	_	15	mark	_	_
14	sulindac	sulindac	NN	NN	_	15	nsubj	_	_
15	activated	activate	VBD	VBD	_	4	advcl	_	_
16	the	the	DT	DT	_	20	det	_	_
17	stress	stress	NN	NN	_	20	compound	_	_
18	responsive	responsive	JJ	JJ	_	20	amod	_	_
19	HSP70B	hsp70b	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	15	dobj	_	_
21	,	,	,	,	_	15	punct	_	_
22	sodium	sodium	NN	NN	_	23	compound	_	_
23	salicylate	salicylate	NN	NN	_	24	nsubj	_	_
24	did	do	VBD	VBD	_	15	parataxis	_	_
25	not	not	RB	RB	_	24	neg	_	_
26	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	10	nmod	_	_
3	,	,	,	,	_	10	punct	_	_
4	only	only	RB	RB	_	6	advmod	_	_
5	a	a	DT	DT	_	6	det	_	_
6	subset	subset	NN	NN	_	10	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	NSAIDs	nsaids	NN	NN	_	6	nmod	_	_
10	induced	induce	VBD	VBD	_	0	root	_	_
11	HSP70	hsp70	NN	NN	_	13	compound	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	species	species	NNS	NNS	_	10	dobj	_	_
14	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	reflect	reflect	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	properties	property	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	HSF1	hsf1	NN	NN	_	5	nmod	_	_
8	which	which	WDT	WDT	_	11	nsubjpass	_	_
9	can	can	MD	MD	_	11	aux	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	activated	activate	VBN	VBN	_	7	acl:relcl	_	_
12	to	to	TO	TO	_	18	case	_	_
13	at	at	IN	IN	_	14	case	_	_
14	least	least	JJS	JJS	_	15	nmod:npmod	_	_
15	two	two	CD	CD	_	18	nummod	_	_
16	DNA	dna	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	forms	form	NNS	NNS	_	11	nmod	_	_
19	only	only	RB	RB	_	20	advmod	_	_
20	one	one	CD	CD	_	23	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	20	nmod	_	_
23	activates	activate	VBZ	VBZ	_	18	acl:relcl	_	_
24	heat	heat	NN	NN	_	26	compound	_	_
25	shock	shock	NN	NN	_	26	compound	_	_
26	promoters	promoter	NNS	NNS	_	23	dobj	_	_
27	and	and	CC	CC	_	3	cc	_	_
28	suggest	suggest	VBP	VBP	_	3	conj	_	_
29	that	that	IN	IN	_	36	mark	_	_
30	individual	individual	JJ	JJ	_	33	amod	_	_
31	NSAID	nsaid	NN	NN	_	33	compound	_	_
32	family	family	NN	NN	_	33	compound	_	_
33	members	member	NNS	NNS	_	36	nsubj	_	_
34	may	may	MD	MD	_	36	aux	_	_
35	differentially	differentially	RB	RB	_	36	advmod	_	_
36	induce	induce	VB	VB	_	28	ccomp	_	_
37	one	one	CD	CD	_	36	dobj	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	other	other	JJ	JJ	_	37	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	forms	form	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	3	punct	_	_

1	Overall	overall	RB	RB	_	2	advmod	_	_
2	therefore	therefore	RB	RB	_	7	advmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	exposure	exposure	NN	NN	_	7	nsubj	_	_
5	to	to	TO	TO	_	6	case	_	_
6	NSAIDs	nsaid	NNS	NNS	_	4	nmod	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	profound	profound	JJ	JJ	_	11	amod	_	_
11	switch	switch	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	7	punct	_	_
19	with	with	IN	IN	_	20	case	_	_
20	suppression	suppression	NN	NN	_	7	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	genes	gene	NNS	NNS	_	20	nmod	_	_
23	involved	involve	VBN	VBN	_	22	acl	_	_
24	in	in	IN	IN	_	26	case	_	_
25	macrophage	macrophage	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	20	cc	_	_
28	induction	induction	NN	NN	_	20	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	stress	stress	NN	NN	_	31	compound	_	_
31	genes	gene	NNS	NNS	_	28	nmod	_	_
32	and	and	CC	CC	_	7	cc	_	_
33	HSF1	hsf1	NN	NN	_	34	nsubj	_	_
34	appears	appear	VBZ	VBZ	_	7	conj	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	play	play	VB	VB	_	34	xcomp	_	_
37	a	a	DT	DT	_	39	det	_	_
38	regulatory	regulatory	JJ	JJ	_	39	amod	_	_
39	role	role	NN	NN	_	36	dobj	_	_
40	in	in	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	effects	effect	NNS	NNS	_	36	nmod	_	_
43	.	.	.	.	_	7	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Recognition	recognition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NFATp/AP-1	nfatp/ap-1	NN	NN	_	5	compound	_	_
4	composite	composite	JJ	JJ	_	5	amod	_	_
5	elements	element	NNS	NNS	_	1	nmod	_	_
6	within	within	IN	IN	_	7	case	_	_
7	genes	gene	NNS	NNS	_	5	nmod	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	upon	upon	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	1	punct	_	_

1	Composite	composite	JJ	JJ	_	2	amod	_	_
2	elements	element	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	regulatory	regulatory	JJ	JJ	_	5	amod	_	_
5	modules	module	NNS	NNS	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	promoters	promoter	NNS	NNS	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	enhancers	enhancer	NNS	NNS	_	7	conj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	consist	consist	VBP	VBP	_	5	acl:relcl	_	_
12	of	of	IN	IN	_	14	case	_	_
13	binding	bind	VBG	VBG	_	14	amod	_	_
14	sites	site	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	two	two	CD	CD	_	21	nummod	_	_
17	different	different	JJ	JJ	_	21	amod	_	_
18	but	but	CC	CC	_	17	cc	_	_
19	synergizing	synergize	VBG	VBG	_	17	conj	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	well-studied	well-studied	JJ	JJ	_	3	amod	_	_
3	example	example	NN	NN	_	13	nsubj	_	_
4	is	be	VBZ	VBZ	_	13	cop	_	_
5	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
6	factors	factor	NNS	NNS	_	13	compound	_	_
7	of	of	IN	IN	_	13	amod	_	_
8	activated	activate	VBN	VBN	_	13	amod	_	_
9	T-cell	t-cell	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	NFAT	nfat	NN	NN	_	13	compound	_	_
12	)	)	-RRB-	-RRB-	_	13	punct	_	_
13	sites	site	NNS	NNS	_	0	root	_	_
14	which	which	WDT	WDT	_	17	nsubj	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	composite	composite	JJ	JJ	_	17	amod	_	_
17	elements	element	NNS	NNS	_	13	acl:relcl	_	_
18	of	of	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	NFATp/c	nfatp/c	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	an	a	DT	DT	_	30	det	_	_
23	activating	activate	VBG	VBG	_	24	amod	_	_
24	protein	protein	NN	NN	_	30	compound	_	_
25	1	1	CD	CD	_	24	nummod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	AP-1	ap-1	NN	NN	_	24	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	site	site	NN	NN	_	20	conj	_	_
31	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	developed	develop	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	computational	computational	JJ	JJ	_	6	amod	_	_
6	approach	approach	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	acl	_	_
9	potential	potential	JJ	JJ	_	12	amod	_	_
10	NFAT	nfat	NN	NN	_	12	compound	_	_
11	target	target	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	8	dobj	_	_
13	which	which	WDT	WDT	_	17	dep	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	a	a	LS	LS	_	17	dep	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	comprises	comprise	VBZ	VBZ	_	6	acl:relcl	_	_
18	an	a	DT	DT	_	20	det	_	_
19	improved	improved	JJ	JJ	_	20	amod	_	_
20	method	method	NN	NN	_	17	dobj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	scan	scan	VB	VB	_	20	acl	_	_
23	for	for	IN	IN	_	27	case	_	_
24	individual	individual	JJ	JJ	_	27	amod	_	_
25	NFAT	nfat	NN	NN	_	27	compound	_	_
26	composite	composite	JJ	JJ	_	27	amod	_	_
27	elements	element	NNS	NNS	_	22	nmod	_	_
28	;	;	:	:	_	17	punct	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	b	b	LS	LS	_	17	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	considers	consider	VBZ	VBZ	_	17	dep	_	_
33	positional	positional	JJ	JJ	_	34	amod	_	_
34	effects	effect	NNS	NNS	_	32	dobj	_	_
35	relative	relative	JJ	JJ	_	34	amod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	transcription	transcription	NN	NN	_	39	compound	_	_
38	start	start	NN	NN	_	39	compound	_	_
39	sites	site	NNS	NNS	_	35	nmod	_	_
40	;	;	:	:	_	17	punct	_	_
41	and	and	CC	CC	_	17	cc	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	c	c	LS	LS	_	17	conj	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	involves	involve	VBZ	VBZ	_	17	dep	_	_
46	cluster	cluster	NN	NN	_	47	compound	_	_
47	analysis	analysis	NN	NN	_	45	dobj	_	_
48	of	of	IN	IN	_	52	case	_	_
49	potential	potential	JJ	JJ	_	52	amod	_	_
50	NFAT	nfat	NN	NN	_	52	compound	_	_
51	composite	composite	JJ	JJ	_	52	amod	_	_
52	elements	element	NNS	NNS	_	47	nmod	_	_
53	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	three	three	CD	CD	_	3	nummod	_	_
3	steps	step	NNS	NNS	_	5	nsubj	_	_
4	progressively	progressively	RB	RB	_	5	advmod	_	_
5	helpX?ed	helpx?ed	VBD	VBD	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	discriminate	discriminate	VB	VB	_	5	xcomp	_	_
8	T-cell-specific	t-cell-specific	JJ	JJ	_	10	amod	_	_
9	promoter	promoter	NN	NN	_	10	compound	_	_
10	sequences	sequence	NNS	NNS	_	7	dobj	_	_
11	against	against	IN	IN	_	14	case	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	regions	region	NNS	NNS	_	7	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	coding	coding	NN	NN	_	14	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	intronic	intronic	JJ	JJ	_	16	conj	_	_
19	sequences	sequence	NNS	NNS	_	16	dep	_	_
20	)	)	-RRB-	-RRB-	_	16	punct	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	same	same	JJ	JJ	_	24	amod	_	_
24	genes	gene	NNS	NNS	_	14	nmod	_	_
25	,	,	,	,	_	14	punct	_	_
26	against	against	IN	IN	_	27	case	_	_
27	promoters	promoter	NNS	NNS	_	14	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	muscle-specific	muscle-specific	JJ	JJ	_	30	amod	_	_
30	genes	gene	NNS	NNS	_	27	nmod	_	_
31	or	or	CC	CC	_	14	cc	_	_
32	against	against	IN	IN	_	34	case	_	_
33	random	random	JJ	JJ	_	34	amod	_	_
34	sequences	sequence	NNS	NNS	_	14	conj	_	_
35	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	6	advcl	_	_
2	this	this	DT	DT	_	3	det	_	_
3	approach	approach	NN	NN	_	1	dobj	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	identified	identify	VBD	VBD	_	0	root	_	_
7	potential	potential	JJ	JJ	_	10	amod	_	_
8	NFAT	nfat	NN	NN	_	10	compound	_	_
9	composite	composite	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	6	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	promoters	promoter	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	receptors	receptor	NNS	NNS	_	10	conj	_	_
19	as	as	RB	RB	_	18	cc	_	_
20	well	well	RB	RB	_	19	mwe	_	_
21	as	as	IN	IN	_	19	mwe	_	_
22	in	in	IN	IN	_	23	case	_	_
23	promoters	promoter	NNS	NNS	_	18	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	genes	gene	NNS	NNS	_	23	nmod	_	_
26	for	for	IN	IN	_	29	case	_	_
27	AP-1	ap-1	NN	NN	_	29	compound	_	_
28	family	family	NN	NN	_	29	compound	_	_
29	members	member	NNS	NNS	_	23	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	Ca2+-binding	ca2+-binding	JJ	JJ	_	32	amod	_	_
32	proteins	protein	NNS	NNS	_	29	appos	_	_
33	and	and	CC	CC	_	23	cc	_	_
34	some	some	DT	DT	_	36	det	_	_
35	other	other	JJ	JJ	_	36	amod	_	_
36	components	component	NNS	NNS	_	23	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	regulatory	regulatory	JJ	JJ	_	40	amod	_	_
40	network	network	NN	NN	_	36	nmod	_	_
41	operating	operate	VBG	VBG	_	40	acl	_	_
42	in	in	IN	IN	_	44	case	_	_
43	activated	activate	VBN	VBN	_	44	amod	_	_
44	T-cells	t-cell	NNS	NNS	_	41	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	other	other	JJ	JJ	_	48	amod	_	_
47	immune	immune	JJ	JJ	_	48	amod	_	_
48	cells	cell	NNS	NNS	_	44	conj	_	_
49	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	method	method	NN	NN	_	6	nsubjpass	_	_
3	developed	develop	VBN	VBN	_	2	acl	_	_
4	can	can	MD	MD	_	6	aux	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	adapted	adapt	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	characterize	characterize	VB	VB	_	6	xcomp	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	identify	identify	VB	VB	_	8	conj	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	composite	composite	JJ	JJ	_	13	amod	_	_
13	elements	element	NNS	NNS	_	8	dobj	_	_
14	as	as	RB	RB	_	8	advmod	_	_
15	well	well	RB	RB	_	14	mwe	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	program	program	NN	NN	_	9	nsubj	_	_
3	for	for	IN	IN	_	7	case	_	_
4	recognition	recognition	NN	NN	_	7	compound	_	_
5	NFAT	nfat	NN	NN	_	7	compound	_	_
6	composite	composite	JJ	JJ	_	7	amod	_	_
7	elements	element	NNS	NNS	_	2	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	available	available	JJ	JJ	_	0	root	_	_
10	through	through	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	World	world	NN	NN	_	14	compound	_	_
13	Wide	wide	NN	NN	_	14	compound	_	_
14	Web	web	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	http://compel.bionet.nsc.ru/FunSite/CompelScan.html	http://compel.bionet.nsc.ru/funsite/compelscan.html	NN	NN	_	14	dep	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	http://transfac.gbf.de/dbsearch/funsitep/s_comp.html	http://transfac.gbf.de/dbsearch/funsitep/s_comp.html	NN	NN	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	.	.	.	.	_	9	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Disruption	disruption	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	alpha	alpha	NN	NN	_	4	compound	_	_
4	beta	beta	NN	NN	_	12	nmod	_	_
5	but	but	CC	CC	_	12	cc	_	_
6	not	not	RB	RB	_	9	neg	_	_
7	of	of	IN	IN	_	9	case	_	_
8	gamma	gamma	NN	NN	_	9	compound	_	_
9	delta	delta	NN	NN	_	12	conj	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	1	nmod	_	_
13	by	by	IN	IN	_	14	case	_	_
14	overexpression	overexpression	NN	NN	_	1	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	helix-loop-helix	helix-loop-helix	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	14	nmod	_	_
19	Id3	id3	NN	NN	_	18	dep	_	_
20	in	in	IN	IN	_	24	case	_	_
21	committed	commit	VBN	VBN	_	24	amod	_	_
22	T	t	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	progenitors	progenitor	NNS	NNS	_	14	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	Enforced	enforce	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	39	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Id3	id3	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	2	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	capacity	capacity	NN	NN	_	7	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	inhibit	inhibit	VB	VB	_	9	acl	_	_
12	many	many	JJ	JJ	_	19	amod	_	_
13	basic	basic	JJ	JJ	_	14	amod	_	_
14	helix-loop-helix	helix-loop-helix	JJ	JJ	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	bHLH	bhlh	JJ	JJ	_	14	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	11	dobj	_	_
20	,	,	,	,	_	2	punct	_	_
21	in	in	IN	IN	_	26	case	_	_
22	human	human	JJ	JJ	_	26	amod	_	_
23	CD34(+)	cd34(+)	JJ	JJ	_	26	amod	_	_
24	hematopoietic	hematopoietic	JJ	JJ	_	26	amod	_	_
25	progenitor	progenitor	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	2	nmod	_	_
27	that	that	WDT	WDT	_	30	nsubj	_	_
28	have	have	VBP	VBP	_	30	aux	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	undergone	undergo	VBN	VBN	_	26	acl:relcl	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	receptor	receptor	NN	NN	_	38	compound	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	TCR	tcr	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	gene	gene	NN	NN	_	38	compound	_	_
38	rearrangements	rearrangement	NNS	NNS	_	30	dobj	_	_
39	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
40	development	development	NN	NN	_	39	dobj	_	_
41	of	of	IN	IN	_	44	case	_	_
42	the	the	DT	DT	_	44	det	_	_
43	transduced	transduce	VBN	VBN	_	44	amod	_	_
44	cells	cell	NNS	NNS	_	40	nmod	_	_
45	into	into	IN	IN	_	47	case	_	_
46	TCRalpha	tcralpha	NN	NN	_	47	compound	_	_
47	beta	beta	NN	NN	_	44	nmod	_	_
48	and	and	CC	CC	_	47	cc	_	_
49	gamma	gamma	NN	NN	_	50	compound	_	_
50	delta	delta	NN	NN	_	47	conj	_	_
51	cells	cell	NNS	NNS	_	47	dep	_	_
52	in	in	IN	IN	_	57	case	_	_
53	a	a	DT	DT	_	57	det	_	_
54	fetal	fetal	JJ	JJ	_	57	amod	_	_
55	thymic	thymic	JJ	JJ	_	57	amod	_	_
56	organ	organ	NN	NN	_	57	compound	_	_
57	culture	culture	NN	NN	_	47	nmod	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	FTOC	ftoc	NN	NN	_	57	appos	_	_
60	)	)	-RRB-	-RRB-	_	59	punct	_	_
61	.	.	.	.	_	39	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	document	document	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	overexpression	overexpression	NN	NN	_	22	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Id3	id3	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	5	punct	_	_
9	in	in	IN	IN	_	10	case	_	_
10	progenitors	progenitor	NNS	NNS	_	5	nmod	_	_
11	that	that	WDT	WDT	_	13	nsubj	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	initiated	initiate	VBN	VBN	_	10	acl:relcl	_	_
14	TCR	tcr	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	rearrangements	rearrangement	NNS	NNS	_	13	dobj	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	pre-T	pre-t	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	22	punct	_	_
22	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
23	development	development	NN	NN	_	22	dobj	_	_
24	into	into	IN	IN	_	26	case	_	_
25	TCRalpha	tcralpha	NN	NN	_	26	compound	_	_
26	beta	beta	NN	NN	_	23	nmod	_	_
27	but	but	CC	CC	_	26	cc	_	_
28	not	not	RB	RB	_	33	neg	_	_
29	into	into	IN	IN	_	33	case	_	_
30	TCRgamma	tcrgamma	NN	NN	_	33	compound	_	_
31	delta	delta	NN	NN	_	33	compound	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	26	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Id3	id3	NN	NN	_	4	nsubj	_	_
4	impedes	impede	VBZ	VBZ	_	0	root	_	_
5	expression	expression	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	recombination	recombination	NN	NN	_	9	compound	_	_
8	activating	activating	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	downregulates	downregulate	VBZ	VBZ	_	4	conj	_	_
12	pre-Talpha	pre-talpha	JJ	JJ	_	13	amod	_	_
13	mRNA	mrna	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	possible	possible	JJ	JJ	_	5	amod	_	_
5	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	12	nmod	_	_
8	Id3	id3	NN	NN	_	9	compound	_	_
9	overexpression	overexpression	NN	NN	_	12	nsubj	_	_
10	can	can	MD	MD	_	12	aux	_	_
11	differentially	differentially	RB	RB	_	12	advmod	_	_
12	affect	affect	VB	VB	_	5	acl:relcl	_	_
13	development	development	NN	NN	_	12	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	pre-T	pre-t	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	into	into	IN	IN	_	19	case	_	_
18	TCRalpha	tcralpha	NN	NN	_	19	compound	_	_
19	beta	beta	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	gamma	gamma	NN	NN	_	22	compound	_	_
22	delta	delta	NN	NN	_	19	conj	_	_
23	cells	cell	NNS	NNS	_	19	dep	_	_
24	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	observed	observe	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	cell	cell	NN	NN	_	8	compound	_	_
6	surface	surface	NN	NN	_	8	compound	_	_
7	CD4(-)CD8(-)CD3(-)	cd4(-)cd8(-)cd3(-)	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	13	nsubj	_	_
9	with	with	IN	IN	_	12	case	_	_
10	rearranged	rearrange	VBN	VBN	_	12	amod	_	_
11	TCR	tcr	NN	NN	_	12	compound	_	_
12	genes	gene	NNS	NNS	_	8	nmod	_	_
13	developed	develop	VBD	VBD	_	3	ccomp	_	_
14	from	from	IN	IN	_	15	case	_	_
15	Id3-transduced	id3-transduced	JJ	JJ	_	21	nmod	_	_
16	but	but	CC	CC	_	21	cc	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	from	from	IN	IN	_	19	case	_	_
19	control-transduced	control-transduced	JJ	JJ	_	21	conj	_	_
20	pre-T	pre-t	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	an	a	DT	DT	_	24	det	_	_
24	FTOC	ftoc	NN	NN	_	13	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	had	have	VBD	VBD	_	0	root	_	_
4	properties	property	NNS	NNS	_	3	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	natural	natural	JJ	JJ	_	8	amod	_	_
8	killer	killer	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	NK	nk	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	pre-T	pre-t	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	8	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	bHLH	bhlh	JJ	JJ	_	6	amod	_	_
6	factors	factor	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	3	ccomp	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	control	control	VB	VB	_	8	xcomp	_	_
11	T	t	NN	NN	_	13	compound	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	development	development	NN	NN	_	10	dobj	_	_
14	after	after	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	T/NK	t/nk	NN	NN	_	18	compound	_	_
17	developmental	developmental	JJ	JJ	_	18	amod	_	_
18	checkpoint	checkpoint	NN	NN	_	10	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Rel/NF-kappaB	rel/nf-kappab	NN	NN	_	3	nsubj	_	_
2	can	can	MD	MD	_	3	aux	_	_
3	trigger	trigger	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	7	det	_	_
5	Notch	notch	NN	NN	_	7	compound	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	3	dobj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	inducing	induce	VBG	VBG	_	3	advcl	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	Jagged1	jagged1	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	ligand	ligand	NN	NN	_	13	appos	_	_
17	for	for	IN	IN	_	19	case	_	_
18	Notch	notch	NN	NN	_	19	compound	_	_
19	receptors	receptor	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Jagged1	jagged1	NN	NN	_	2	nsubj	_	_
2	belongs	belong	VBZ	VBZ	_	0	root	_	_
3	to	to	TO	TO	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	DSL	dsl	NN	NN	_	8	compound	_	_
6	family	family	NN	NN	_	8	compound	_	_
7	of	of	IN	IN	_	8	amod	_	_
8	ligands	ligand	NNS	NNS	_	2	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	Notch	notch	NN	NN	_	11	compound	_	_
11	receptors	receptor	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	control	control	VBP	VBP	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	15	det	_	_
15	proliferation	proliferation	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	differentiation	differentiation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	various	various	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lineages	lineage	NNS	NNS	_	15	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	about	about	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	regulate	regulate	VBP	VBP	_	9	acl:relcl	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	Jagged1	jagged1	NN	NN	_	10	nsubj	_	_
7	is	be	VBZ	VBZ	_	10	cop	_	_
8	a	a	DT	DT	_	10	det	_	_
9	Rel/NF-kappaB-responsive	rel/nf-kappab-responsive	JJ	JJ	_	10	amod	_	_
10	gene	gene	NN	NN	_	4	ccomp	_	_
11	.	.	.	.	_	4	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	c-Rel	c-rel	NN	NN	_	5	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	RelA	rela	NN	NN	_	2	conj	_	_
5	induced	induce	VBD	VBD	_	0	root	_	_
6	jagged1	jagged1	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	5	punct	_	_
10	whereas	whereas	IN	IN	_	5	dep	_	_
11	a	a	DT	DT	_	12	det	_	_
12	mutant	mutant	NN	NN	_	16	nsubj	_	_
13	defective	defective	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	15	case	_	_
15	transactivation	transactivation	NN	NN	_	12	nmod	_	_
16	did	do	VBD	VBD	_	5	parataxis	_	_
17	not	not	RB	RB	_	16	neg	_	_
18	.	.	.	.	_	5	punct	_	_

1	Importantly	importantly	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	jagged1	jagged1	NN	NN	_	4	compound	_	_
4	transcripts	transcript	NNS	NNS	_	7	nsubjpass	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	upregulated	upregulate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	11	case	_	_
9	endogenous	endogenous	JJ	JJ	_	11	amod	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	activation	activation	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	this	this	DT	DT	_	14	det	_	_
14	effect	effect	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	inhibited	inhibit	VBN	VBN	_	7	conj	_	_
17	by	by	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	dominant	dominant	JJ	JJ	_	20	amod	_	_
20	mutant	mutant	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IkappaBalpha	ikappabalpha	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	a	a	DT	DT	_	26	det	_	_
25	physiological	physiological	JJ	JJ	_	26	amod	_	_
26	inhibitor	inhibitor	NN	NN	_	22	appos	_	_
27	of	of	IN	IN	_	28	case	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Cell	cell	NN	NN	_	3	compound	_	_
2	surface	surface	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Jagged1	jagged1	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	c-Rel-expressing	c-rel-expressing	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	monolayers	monolayer	NNS	NNS	_	5	nmod	_	_
10	led	lead	VBD	VBD	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	interaction	interaction	NN	NN	_	10	nmod	_	_
15	with	with	IN	IN	_	16	case	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
17	expressing	express	VBG	VBG	_	16	acl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Notch1/TAN-1	notch1/tan-1	NN	NN	_	20	compound	_	_
20	receptor	receptor	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	correlated	correlate	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	initiation	initiation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	signaling	signal	VBG	VBG	_	8	amod	_	_
8	downstream	downstream	RB	RB	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Notch	notch	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	as	as	IN	IN	_	16	case	_	_
13	evidenced	evidence	VBN	VBN	_	16	case	_	_
14	by	by	IN	IN	_	16	case	_	_
15	increased	increase	VBN	VBN	_	16	amod	_	_
16	levels	level	NNS	NNS	_	2	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	HES-1	hes-1	NN	NN	_	19	compound	_	_
19	transcripts	transcript	NNS	NNS	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	co-cultivated	co-cultivated	JJ	JJ	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	19	cc	_	_
25	of	of	IN	IN	_	27	case	_	_
26	CD23	cd23	NN	NN	_	27	compound	_	_
27	transcripts	transcript	NNS	NNS	_	19	conj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	co-cultivated	co-cultivated	JJ	JJ	_	31	amod	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Consistent	consistent	JJ	JJ	_	9	ccomp	_	_
2	with	with	IN	IN	_	5	case	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	Rel/NF-kappaB-dependent	rel/nf-kappab-dependent	JJ	JJ	_	5	amod	_	_
5	induction	induction	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	9	punct	_	_
7	Jagged1	jagged1	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	found	find	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	13	mark	_	_
11	be	be	VB	VB	_	13	auxpass	_	_
12	highly	highly	RB	RB	_	13	advmod	_	_
13	expressed	express	VBN	VBN	_	9	xcomp	_	_
14	in	in	IN	IN	_	17	case	_	_
15	splenic	splenic	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	where	where	WRB	WRB	_	21	advmod	_	_
19	c-Rel	c-rel	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	expressed	express	VBN	VBN	_	17	ccomp	_	_
22	constitutively	constitutively	RB	RB	_	21	advmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	c-Rel	c-rel	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	trigger	trigger	VB	VB	_	3	ccomp	_	_
8	the	the	DT	DT	_	11	det	_	_
9	Notch	notch	NN	NN	_	11	compound	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	neighboring	neighboring	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	inducing	induce	VBG	VBG	_	7	advcl	_	_
17	jagged1	jagged1	NN	NN	_	16	dep	_	_
18	gene	gene	NN	NN	_	16	dep	_	_
19	expression	expression	NN	NN	_	16	dep	_	_
20	,	,	,	,	_	7	punct	_	_
21	and	and	CC	CC	_	7	cc	_	_
22	suggest	suggest	VBP	VBP	_	7	conj	_	_
23	a	a	DT	DT	_	24	det	_	_
24	role	role	NN	NN	_	22	dobj	_	_
25	for	for	IN	IN	_	26	case	_	_
26	Jagged1	jagged1	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	B-cell	b-cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	26	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	differentiation	differentiation	NN	NN	_	29	conj	_	_
32	or	or	CC	CC	_	29	cc	_	_
33	function	function	NN	NN	_	29	conj	_	_
34	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	highlight	highlight	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	potential	potential	NN	NN	_	4	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	interplay	interplay	NN	NN	_	6	nmod	_	_
10	between	between	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	Notch	notch	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	12	conj	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	immune	immune	JJ	JJ	_	20	amod	_	_
20	system	system	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	control	control	NN	NN	_	16	dep	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	IL-5	il-5	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	by	by	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	helper	helper	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	:	:	:	:	_	16	punct	_	_
13	IL-5	il-5	NN	NN	_	14	compound	_	_
14	synthesis	synthesis	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	regulated	regulate	VBN	VBN	_	0	root	_	_
17	independently	independently	RB	RB	_	16	advmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	IL-2	il-2	NN	NN	_	16	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	IL-4	il-4	NN	NN	_	22	compound	_	_
22	synthesis	synthesis	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	16	punct	_	_

1	BACKGROUND	background	NN	NN	_	6	dep	_	_
2	:	:	:	:	_	6	punct	_	_
3	IL-5	il-5	NN	NN	_	6	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	6	auxpass	_	_
5	fundamentally	fundamentally	RB	RB	_	6	advmod	_	_
6	involved	involve	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	eosinophilic	eosinophilic	JJ	JJ	_	9	amod	_	_
9	inflammation	inflammation	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Control	control	NN	NN	_	7	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	IL-5	il-5	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	1	nmod	_	_
5	may	may	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	cop	_	_
7	effective	effective	JJ	JJ	_	0	root	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	management	management	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	allergic	allergic	JJ	JJ	_	13	amod	_	_
13	diseases	disease	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	aimed	aim	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	find	find	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	regulate	regulate	VBP	VBP	_	9	acl:relcl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	IL-5	il-5	NN	NN	_	14	compound	_	_
14	gene	gene	NN	NN	_	11	dobj	_	_
15	to	to	TO	TO	_	17	mark	_	_
16	selectively	selectively	RB	RB	_	17	advmod	_	_
17	control	control	VB	VB	_	14	acl	_	_
18	IL-5	il-5	NN	NN	_	19	compound	_	_
19	synthesis	synthesis	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	4	punct	_	_

1	METHODS	method	NNS	NNS	_	10	dep	_	_
2	:	:	:	:	_	10	punct	_	_
3	Allergen-specific	allergen-specific	JJ	JJ	_	5	amod	_	_
4	T-cell	t-cell	NN	NN	_	5	compound	_	_
5	clones	clone	NNS	NNS	_	10	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	T-cell	t-cell	NN	NN	_	8	compound	_	_
8	hybridomas	hybridoma	NNS	NNS	_	5	conj	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	established	establish	VBN	VBN	_	0	root	_	_
11	from	from	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	19	case	_	_
19	asthma	asthma	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	and	and	CC	CC	_	10	cc	_	_
22	the	the	DT	DT	_	24	det	_	_
23	transcriptional	transcriptional	JJ	JJ	_	24	amod	_	_
24	regulation	regulation	NN	NN	_	30	nsubjpass	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	IL-5	il-5	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	24	nmod	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	investigated	investigate	VBN	VBN	_	10	conj	_	_
31	with	with	IN	IN	_	33	case	_	_
32	transient	transient	JJ	JJ	_	33	amod	_	_
33	transfection	transfection	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	electrophoretic	electrophoretic	JJ	JJ	_	38	amod	_	_
36	mobility	mobility	NN	NN	_	38	compound	_	_
37	shift	shift	NN	NN	_	38	compound	_	_
38	analysis	analysis	NN	NN	_	33	conj	_	_
39	.	.	.	.	_	10	punct	_	_

1	RESULTS	result	NNS	NNS	_	14	nsubjpass	_	_
2	:	:	:	:	_	14	punct	_	_
3	A	a	DT	DT	_	8	det	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	IL-5	il-5	NN	NN	_	8	compound	_	_
6	promoter/enhancer-luciferase	promoter/enhancer-luciferase	NN	NN	_	8	compound	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	construct	construct	NN	NN	_	14	nsubjpass	_	_
9	,	,	,	,	_	8	punct	_	_
10	pIL-5(-511)	pil-5(-511)	NN	NN	_	11	compound	_	_
11	Luc	luc	NN	NN	_	8	appos	_	_
12	,	,	,	,	_	14	punct	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	transcribed	transcribe	VBN	VBN	_	0	root	_	_
15	on	on	IN	IN	_	16	case	_	_
16	activation	activation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	IL-5-producing	il-5-producing	JJ	JJ	_	20	amod	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	clones	clone	NNS	NNS	_	16	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	but	but	CC	CC	_	20	cc	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	IL-5-nonproducing	il-5-nonproducing	JJ	JJ	_	25	amod	_	_
25	clones	clone	NNS	NNS	_	20	conj	_	_
26	.	.	.	.	_	14	punct	_	_

1	pIL-5(-511)	pil-5(-511)	NN	NN	_	2	compound	_	_
2	Luc	luc	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	transcribed	transcribe	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	T-cell	t-cell	NN	NN	_	7	compound	_	_
7	hybridomas	hybridoma	NNS	NNS	_	4	nmod	_	_
8	derived	derive	VBN	VBN	_	7	acl	_	_
9	from	from	IN	IN	_	10	case	_	_
10	fusion	fusion	NN	NN	_	8	nmod	_	_
11	between	between	IN	IN	_	14	case	_	_
12	IL-5-producing	il-5-producing	JJ	JJ	_	14	amod	_	_
13	T-cell	t-cell	NN	NN	_	14	compound	_	_
14	clones	clone	NNS	NNS	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	an	a	DT	DT	_	20	det	_	_
17	IL-5	il-5	NN	NN	_	20	compound	_	_
18	gene-nonexpressing	gene-nonexpressing	JJ	JJ	_	20	amod	_	_
19	T-cell	t-cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	7	punct	_	_
22	but	but	CC	CC	_	7	cc	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	by	by	IN	IN	_	25	case	_	_
25	hybridomas	hybridoma	NNS	NNS	_	7	conj	_	_
26	derived	derive	VBN	VBN	_	25	acl	_	_
27	from	from	IN	IN	_	30	case	_	_
28	IL-5-nonproducing	il-5-nonproducing	JJ	JJ	_	30	amod	_	_
29	T-cell	t-cell	NN	NN	_	30	compound	_	_
30	clones	clone	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	IL-5	il-5	NN	NN	_	2	compound	_	_
2	synthesis	synthesis	NN	NN	_	6	nsubjpass	_	_
3	was	be	VBD	VBD	_	6	auxpass	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	only	only	RB	RB	_	6	cc:preconj	_	_
6	induced	induce	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	T-cell	t-cell	NN	NN	_	10	compound	_	_
9	receptor	receptor	NN	NN	_	10	compound	_	_
10	stimulation	stimulation	NN	NN	_	6	nmod	_	_
11	but	but	CC	CC	_	6	cc	_	_
12	also	also	RB	RB	_	6	conj	_	_
13	by	by	IN	IN	_	16	case	_	_
14	IL-2	il-2	NN	NN	_	16	compound	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	stimulation	stimulation	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Binding	binding	NN	NN	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-AT	nf-at	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	3	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	AP-1	ap-1	NN	NN	_	3	conj	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	17	case	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	receptor	receptor	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	TcR	tcr	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	stimulation	stimulation	NN	NN	_	10	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	although	although	IN	IN	_	21	mark	_	_
20	there	there	EX	EX	_	21	expl	_	_
21	was	be	VBD	VBD	_	10	advcl	_	_
22	no	no	DT	DT	_	24	neg	_	_
23	significant	significant	JJ	JJ	_	24	amod	_	_
24	upregulation	upregulation	NN	NN	_	21	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	binding	binding	NN	NN	_	24	nmod	_	_
27	by	by	IN	IN	_	29	case	_	_
28	IL-2	il-2	NN	NN	_	29	compound	_	_
29	stimulation	stimulation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	10	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	11	dep	_	_
2	:	:	:	:	_	11	punct	_	_
3	IL-5	il-5	NN	NN	_	4	compound	_	_
4	synthesis	synthesis	NN	NN	_	11	nsubjpass	_	_
5	by	by	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	helper	helper	NN	NN	_	9	compound	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	regulated	regulate	VBN	VBN	_	0	root	_	_
12	at	at	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
15	level	level	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	unique	unique	JJ	JJ	_	4	amod	_	_
3	transcriptional	transcriptional	JJ	JJ	_	4	amod	_	_
4	mechanism	mechanism	NN	NN	_	14	nsubj	_	_
5	distinct	distinct	JJ	JJ	_	4	amod	_	_
6	from	from	IN	IN	_	7	case	_	_
7	those	those	DT	DT	_	5	nmod	_	_
8	regulating	regulate	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	IL-2	il-2	NN	NN	_	8	dobj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	IL-4	il-4	NN	NN	_	10	conj	_	_
13	genes	gene	NNS	NNS	_	10	dep	_	_
14	seems	seem	VBZ	VBZ	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	control	control	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-5	il-5	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	14	punct	_	_

1	Selective	selective	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	IL-5	il-5	NN	NN	_	6	compound	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	2	nmod	_	_
7	may	may	MD	MD	_	9	aux	_	_
8	be	be	VB	VB	_	9	cop	_	_
9	useful	useful	JJ	JJ	_	0	root	_	_
10	for	for	IN	IN	_	11	mark	_	_
11	treating	treat	VBG	VBG	_	9	advcl	_	_
12	eosinophlic	eosinophlic	JJ	JJ	_	13	amod	_	_
13	inflammation	inflammation	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	9	punct	_	_

1	Regulation	regulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	8	case	_	_
3	low	low	JJ	JJ	_	8	amod	_	_
4	shear	shear	NN	NN	_	8	compound	_	_
5	flow-induced	flow-induced	JJ	JJ	_	8	amod	_	_
6	HAEC	haec	NNS	NNS	_	8	compound	_	_
7	VCAM-1	vcam-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	1	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	adhesion	adhesion	NN	NN	_	8	conj	_	_
12	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	22	mark	_	_
5	prolonged	prolonged	JJ	JJ	_	6	amod	_	_
6	exposure	exposure	NN	NN	_	22	nsubjpass	_	_
7	of	of	IN	IN	_	11	case	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	aortic	aortic	JJ	JJ	_	11	amod	_	_
10	endothelial	endothelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	HAEC	haec	NNS	NNS	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	to	to	TO	TO	_	20	case	_	_
16	low	low	JJ	JJ	_	20	amod	_	_
17	shear	shear	NN	NN	_	20	compound	_	_
18	stress	stress	NN	NN	_	20	compound	_	_
19	flow	flow	NN	NN	_	20	compound	_	_
20	patterns	pattern	NNS	NNS	_	6	nmod	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	3	ccomp	_	_
23	with	with	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	sustained	sustained	JJ	JJ	_	26	amod	_	_
26	increase	increase	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	activated	activated	JJ	JJ	_	30	amod	_	_
30	form	form	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	transcriptional	transcriptional	JJ	JJ	_	34	amod	_	_
34	regulator	regulator	NN	NN	_	30	nmod	_	_
35	nuclear	nuclear	JJ	JJ	_	36	amod	_	_
36	factor-kappaB	factor-kappab	NN	NN	_	34	dep	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	NF-kappaB	nf-kappab	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigate	investigate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	hypothesis	hypothesis	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	low	low	JJ	JJ	_	9	amod	_	_
8	shear-induced	shear-induced	JJ	JJ	_	9	amod	_	_
9	activation	activation	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	9	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	responsible	responsible	JJ	JJ	_	5	dep	_	_
14	for	for	IN	IN	_	16	case	_	_
15	enhanced	enhance	VBN	VBN	_	16	amod	_	_
16	expression	expression	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	vascular	vascular	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	adhesion	adhesion	NN	NN	_	21	compound	_	_
21	molecule	molecule	NN	NN	_	16	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	VCAM-1	vcam-1	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	resulting	result	VBG	VBG	_	16	acl	_	_
26	in	in	IN	IN	_	33	case	_	_
27	augmented	augmented	JJ	JJ	_	33	amod	_	_
28	endothelial	endothelial	JJ	JJ	_	33	amod	_	_
29	cell-monocyte	cell-monocyte	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	EC-Mn	ec-mn	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	adhesion	adhesion	NN	NN	_	25	nmod	_	_
34	and	and	CC	CC	_	13	cc	_	_
35	that	that	IN	IN	_	39	mark	_	_
36	this	this	DT	DT	_	37	det	_	_
37	activation	activation	NN	NN	_	39	nsubj	_	_
38	is	be	VBZ	VBZ	_	39	cop	_	_
39	dependent	dependent	JJ	JJ	_	13	conj	_	_
40	on	on	IN	IN	_	43	case	_	_
41	intracellular	intracellular	JJ	JJ	_	43	amod	_	_
42	oxidant	oxidant	JJ	JJ	_	43	amod	_	_
43	activity	activity	NN	NN	_	39	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	Before	before	IN	IN	_	2	case	_	_
2	exposure	exposure	NN	NN	_	16	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	low	low	JJ	JJ	_	5	amod	_	_
5	shear	shear	NN	NN	_	2	nmod	_	_
6	(	(	-LRB-	-LRB-	_	8	punct	_	_
7	2	2	CD	CD	_	8	nummod	_	_
8	dyn/cm2	dyn/cm2	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	for	for	IN	IN	_	12	case	_	_
11	6	6	CD	CD	_	12	nummod	_	_
12	h	h	NN	NN	_	2	nmod	_	_
13	,	,	,	,	_	16	punct	_	_
14	HAEC	haec	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	preincubated	preincubate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	23	nmod	_	_
18	or	or	CC	CC	_	23	cc	_	_
19	without	without	IN	IN	_	23	conj	_	_
20	the	the	DT	DT	_	23	dep	_	_
21	antioxidants	antioxidant	NNS	NNS	_	23	compound	_	_
22	pyrrolidine	pyrrolidine	NN	NN	_	23	compound	_	_
23	dithiocarbamate	dithiocarbamate	NN	NN	_	16	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PDTC	pdtc	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	N-acetyl-L-cysteine	n-acetyl-l-cysteine	NN	NN	_	23	conj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	NAC	nac	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	.	.	.	.	_	16	punct	_	_

1	PDTC	pdtc	NN	NN	_	3	nsubj	_	_
2	strongly	strongly	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	low	low	JJ	JJ	_	6	amod	_	_
5	shear-induced	shear-induced	JJ	JJ	_	6	amod	_	_
6	activation	activation	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	6	punct	_	_
10	expression	expression	NN	NN	_	6	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	VCAM-1	vcam-1	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	EC-Mn	ec-mn	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	6	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Paradoxically	paradoxically	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	NAC	nac	NN	NN	_	4	nsubj	_	_
4	exerted	exert	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	positive	positive	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	4	dobj	_	_
8	on	on	IN	IN	_	12	case	_	_
9	low	low	JJ	JJ	_	12	amod	_	_
10	shear-induced	shear-induced	JJ	JJ	_	12	amod	_	_
11	VCAM-1	vcam-1	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	4	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	EC-Mn	ec-mn	NN	NN	_	15	compound	_	_
15	adhesion	adhesion	NN	NN	_	12	conj	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	only	only	RB	RB	_	18	advmod	_	_
18	slightly	slightly	RB	RB	_	19	advmod	_	_
19	downregulated	downregulated	JJ	JJ	_	4	conj	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	cytokine-induced	cytokine-induced	JJ	JJ	_	5	amod	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	10	nsubjpass	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	VCAM-1	vcam-1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	conj	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	blocked	block	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	PDTC	pdtc	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	NAC	nac	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	nsubj	_	_
6	plays	play	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	9	det	_	_
8	key	key	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	14	case	_	_
11	low	low	JJ	JJ	_	14	amod	_	_
12	shear-induced	shear-induced	JJ	JJ	_	14	amod	_	_
13	VCAM-1	vcam-1	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	6	nmod	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	that	that	IN	IN	_	28	mark	_	_
17	pathways	pathway	NNS	NNS	_	28	nsubjpass	_	_
18	mediating	mediate	VBG	VBG	_	17	acl	_	_
19	low	low	JJ	JJ	_	20	amod	_	_
20	shear-	shear-	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	cytokine-induced	cytokine-induced	JJ	JJ	_	24	amod	_	_
23	EC-Mn	ec-mn	NN	NN	_	24	compound	_	_
24	adhesion	adhesion	NN	NN	_	20	conj	_	_
25	may	may	MD	MD	_	28	aux	_	_
26	be	be	VB	VB	_	28	auxpass	_	_
27	differentially	differentially	RB	RB	_	28	advmod	_	_
28	regulated	regulate	VBN	VBN	_	6	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	localization	localization	NN	NN	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	formation	formation	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	10	case	_	_
6	beta-catenin-lymphoid	beta-catenin-lymphoid	JJ	JJ	_	10	amod	_	_
7	enhancer	enhancer	NN	NN	_	10	compound	_	_
8	factor	factor	NN	NN	_	10	compound	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	complexes	complex	NNS	NNS	_	2	nmod	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	sufficient	sufficient	JJ	JJ	_	0	root	_	_
14	for	for	IN	IN	_	15	case	_	_
15	activation	activation	NN	NN	_	13	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	response	response	NN	NN	_	12	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	activation	activation	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	Wnt	wnt	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	beta-catenin	beta-catenin	NN	NN	_	12	nsubj	_	_
12	accumulates	accumulate	VBZ	VBZ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	nucleus	nucleus	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	where	where	WRB	WRB	_	19	advmod	_	_
18	it	it	PRP	PRP	_	19	nsubj	_	_
19	cooperates	cooperate	VBZ	VBZ	_	15	acl:relcl	_	_
20	with	with	IN	IN	_	32	case	_	_
21	LEF/TCF	lef/tcf	NN	NN	_	32	compound	_	_
22	(	(	-LRB-	-LRB-	_	26	punct	_	_
23	for	for	IN	IN	_	26	case	_	_
24	lymphoid	lymphoid	JJ	JJ	_	26	amod	_	_
25	enhancer	enhancer	NN	NN	_	26	compound	_	_
26	factor	factor	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	T-cell	t-cell	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	26	conj	_	_
30	)	)	-RRB-	-RRB-	_	26	punct	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	19	nmod	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	activate	activate	VB	VB	_	19	xcomp	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	expression	expression	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	19	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	beta-catenin	beta-catenin	NN	NN	_	6	nsubj	_	_
6	undergoes	undergo	VBZ	VBZ	_	2	acl:relcl	_	_
7	this	this	DT	DT	_	8	det	_	_
8	shift	shift	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	location	location	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	participates	participate	VBZ	VBZ	_	6	conj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	transcription	transcription	NN	NN	_	14	nmod	_	_
18	are	be	VBP	VBP	_	19	aux	_	_
19	unknown	unknown	JJ	JJ	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	beta-catenin	beta-catenin	NN	NN	_	8	nsubjpass	_	_
6	can	can	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	imported	import	VBN	VBN	_	2	ccomp	_	_
9	into	into	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	nucleus	nucleus	NN	NN	_	8	nmod	_	_
12	independently	independently	RB	RB	_	11	advmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	LEF/TCF	lef/tcf	NN	NN	_	15	compound	_	_
15	binding	binding	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	it	it	PRP	PRP	_	22	nsubjpass	_	_
19	may	may	MD	MD	_	22	aux	_	_
20	also	also	RB	RB	_	22	advmod	_	_
21	be	be	VB	VB	_	22	auxpass	_	_
22	exported	export	VBN	VBN	_	8	conj	_	_
23	from	from	IN	IN	_	24	case	_	_
24	nuclei	nucleus	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	introduced	introduce	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	small	small	JJ	JJ	_	6	amod	_	_
6	deletion	deletion	NN	NN	_	3	dobj	_	_
7	within	within	IN	IN	_	8	case	_	_
8	beta-catenin	beta-catenin	JJ	JJ	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	Delta19	delta19	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	disrupts	disrupt	VBZ	VBZ	_	8	acl:relcl	_	_
14	binding	binding	NN	NN	_	13	dobj	_	_
15	to	to	TO	TO	_	16	case	_	_
16	LEF-1	lef-1	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	E-cadherin	e-cadherin	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	APC	apc	NN	NN	_	16	conj	_	_
22	but	but	CC	CC	_	16	cc	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	axin	axin	NN	NN	_	16	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	4	det	_	_
2	Delta19	delta19	NN	NN	_	4	compound	_	_
3	beta-catenin	beta-catenin	NN	NN	_	4	compound	_	_
4	mutant	mutant	NN	NN	_	5	nsubj	_	_
5	localizes	localize	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	nucleus	nucleus	NN	NN	_	5	nmod	_	_
9	because	because	IN	IN	_	15	mark	_	_
10	it	it	PRP	PRP	_	15	nsubjpass	_	_
11	may	may	MD	MD	_	15	aux	_	_
12	not	not	RB	RB	_	15	neg	_	_
13	be	be	VB	VB	_	15	auxpass	_	_
14	efficiently	efficiently	RB	RB	_	15	advmod	_	_
15	sequestered	sequester	VBN	VBN	_	5	advcl	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cytoplasm	cytoplasm	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	localization	localization	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Delta19	delta19	NN	NN	_	3	nmod	_	_
6	definitively	definitively	RB	RB	_	7	advmod	_	_
7	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	20	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	mechanisms	mechanism	NNS	NNS	_	20	nsubj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	14	nmod	_	_
13	beta-catenin	beta-catenin	NN	NN	_	14	nsubj	_	_
14	localizes	localize	VBZ	VBZ	_	10	acl:relcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	nucleus	nucleus	NN	NN	_	14	nmod	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	completely	completely	RB	RB	_	20	advmod	_	_
20	independent	independent	JJ	JJ	_	7	ccomp	_	_
21	of	of	IN	IN	_	23	case	_	_
22	LEF/TCF	lef/tcf	NN	NN	_	23	compound	_	_
23	factors	factor	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	beta-Catenin	beta-catenin	NN	NN	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	LEF-1	lef-1	NN	NN	_	4	compound	_	_
4	complexes	complex	NNS	NNS	_	1	conj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	activate	activate	VB	VB	_	0	root	_	_
7	reporter	reporter	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	transformed	transform	VBN	VBN	_	15	amod	_	_
13	T-lymphocyte	t-lymphocyte	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	6	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	Jurkat	jurkat	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	but	but	CC	CC	_	15	cc	_	_
20	not	not	RB	RB	_	24	neg	_	_
21	in	in	IN	IN	_	24	case	_	_
22	normal	normal	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	lymphocytes	lymphocyte	NNS	NNS	_	15	conj	_	_
25	,	,	,	,	_	6	punct	_	_
26	even	even	RB	RB	_	31	advmod	_	_
27	though	though	IN	IN	_	31	mark	_	_
28	both	both	DT	DT	_	29	det	_	_
29	factors	factor	NNS	NNS	_	31	nsubj	_	_
30	are	be	VBP	VBP	_	31	cop	_	_
31	nuclear	nuclear	JJ	JJ	_	6	advcl	_	_
32	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	localization	localization	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	both	both	DT	DT	_	6	det	_	_
6	factors	factor	NNS	NNS	_	3	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	sufficient	sufficient	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	14	case	_	_
14	activation	activation	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Excess	excess	JJ	JJ	_	2	amod	_	_
2	beta-catenin	beta-catenin	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	squelch	squelch	VB	VB	_	0	root	_	_
5	reporter	reporter	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	dobj	_	_
8	by	by	IN	IN	_	10	case	_	_
9	LEF-1-beta-catenin	lef-1-beta-catenin	NN	NN	_	10	compound	_	_
10	complexes	complex	NNS	NNS	_	7	nmod	_	_
11	but	but	CC	CC	_	7	cc	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	activation	activation	NN	NN	_	7	conj	_	_
14	by	by	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	VP16	vp16	NN	NN	_	17	dep	_	_
19	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	data	datum	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	third	third	JJ	JJ	_	10	amod	_	_
10	component	component	NN	NN	_	12	nsubj	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	necessary	necessary	JJ	JJ	_	6	ccomp	_	_
13	for	for	IN	IN	_	15	case	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	this	this	DT	DT	_	20	det	_	_
19	third	third	JJ	JJ	_	20	amod	_	_
20	component	component	NN	NN	_	22	nsubj	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	vary	vary	VB	VB	_	12	conj	_	_
23	with	with	IN	IN	_	25	case	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	type	type	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Paradoxical	paradoxical	JJ	JJ	_	3	amod	_	_
2	priming	priming	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	0	root	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-10	il-10	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	cytokine	cytokine	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	3	nmod	_	_
9	.	.	.	.	_	3	punct	_	_

1	IL-10	il-10	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	well-known	well-known	JJ	JJ	_	5	amod	_	_
5	immunosuppressive	immunosuppressive	JJ	JJ	_	0	root	_	_
6	and/or	and/or	CC	CC	_	5	cc	_	_
7	anti-inflammatory	anti-inflammatory	JJ	JJ	_	5	conj	_	_
8	cytokine	cytokine	NN	NN	_	5	dep	_	_
9	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	in	in	FW	FW	_	7	compound	_	_
6	vitro	vitro	FW	FW	_	7	dep	_	_
7	experimental	experimental	JJ	JJ	_	8	amod	_	_
8	studies	study	NNS	NNS	_	4	dobj	_	_
9	in	in	IN	IN	_	10	case	_	_
10	which	which	WDT	WDT	_	12	nmod	_	_
11	IL-10	il-10	NN	NN	_	12	nsubj	_	_
12	primed	prime	VBD	VBD	_	8	acl:relcl	_	_
13	leukocytes	leukocyte	NNS	NNS	_	12	dobj	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	led	lead	VBD	VBD	_	12	conj	_	_
16	to	to	TO	TO	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	enhanced	enhance	VBN	VBN	_	19	amod	_	_
19	production	production	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	tumor	tumor	NN	NN	_	23	compound	_	_
22	necrosis	necrosis	NN	NN	_	23	compound	_	_
23	factor	factor	NN	NN	_	19	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	TNF	tnf	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	upon	upon	IN	IN	_	29	case	_	_
28	further	further	JJ	JJ	_	29	amod	_	_
29	stimulation	stimulation	NN	NN	_	19	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	lipopolysaccharide	lipopolysaccharide	NN	NN	_	29	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	LPS	lps	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	4	punct	_	_

1	Monocytes	monocyte	NNS	NNS	_	29	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
4	blood	blood	NN	NN	_	6	compound	_	_
5	mononuclear	mononuclear	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	1	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	PBMC	pbmc	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	prepared	prepare	VBN	VBN	_	1	acl	_	_
11	from	from	IN	IN	_	13	case	_	_
12	whole	whole	JJ	JJ	_	13	amod	_	_
13	blood	blood	NN	NN	_	10	nmod	_	_
14	maintained	maintain	VBN	VBN	_	13	acl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	20	20	CD	CD	_	17	nummod	_	_
17	h	h	NN	NN	_	14	nmod	_	_
18	at	at	IN	IN	_	21	case	_	_
19	37	37	CD	CD	_	21	nummod	_	_
20	degrees	degree	NNS	NNS	_	21	compound	_	_
21	C	c	NN	NN	_	14	nmod	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	presence	presence	NN	NN	_	14	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	recombinant	recombinant	JJ	JJ	_	28	amod	_	_
27	human	human	JJ	JJ	_	28	amod	_	_
28	IL-10	il-10	NN	NN	_	24	nmod	_	_
29	had	have	VBD	VBD	_	0	root	_	_
30	an	a	DT	DT	_	32	det	_	_
31	enhanced	enhance	VBN	VBN	_	32	amod	_	_
32	capacity	capacity	NN	NN	_	29	dobj	_	_
33	to	to	TO	TO	_	34	mark	_	_
34	produce	produce	VB	VB	_	32	acl	_	_
35	TNF	tnf	NN	NN	_	34	dobj	_	_
36	in	in	IN	IN	_	37	case	_	_
37	response	response	NN	NN	_	34	nmod	_	_
38	to	to	TO	TO	_	39	case	_	_
39	LPS	lps	NN	NN	_	37	nmod	_	_
40	.	.	.	.	_	29	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	14	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	TNF	tnf	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	LPS-induced	lps-induced	JJ	JJ	_	7	amod	_	_
7	IL-6	il-6	NN	NN	_	14	nsubjpass	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	spontaneous	spontaneous	JJ	JJ	_	10	amod	_	_
10	IL-1ra	il-1ra	NN	NN	_	7	conj	_	_
11	production	production	NN	NN	_	7	dep	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	also	also	RB	RB	_	14	advmod	_	_
14	enhanced	enhance	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	When	when	WRB	WRB	_	6	advmod	_	_
2	isolated	isolate	VBN	VBN	_	3	amod	_	_
3	PBMC	pbmc	NN	NN	_	6	nsubjpass	_	_
4	were	be	VBD	VBD	_	6	auxpass	_	_
5	first	first	RB	RB	_	6	advmod	_	_
6	cultured	culture	VBN	VBN	_	51	advcl	_	_
7	for	for	IN	IN	_	9	case	_	_
8	20	20	CD	CD	_	9	nummod	_	_
9	h	h	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-10	il-10	NN	NN	_	12	nmod	_	_
15	on	on	IN	IN	_	16	case	_	_
16	Teflon	teflon	NN	NN	_	6	nmod	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	prevent	prevent	VB	VB	_	6	xcomp	_	_
19	adherence	adherence	NN	NN	_	18	dobj	_	_
20	,	,	,	,	_	6	punct	_	_
21	washed	wash	VBN	VBN	_	6	conj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	remove	remove	VB	VB	_	21	xcomp	_	_
24	IL-10	il-10	NN	NN	_	23	dobj	_	_
25	and	and	CC	CC	_	6	cc	_	_
26	then	then	RB	RB	_	28	advmod	_	_
27	further	further	RB	RB	_	28	advmod	_	_
28	cultured	culture	VBN	VBN	_	6	conj	_	_
29	in	in	IN	IN	_	31	case	_	_
30	plastic	plastic	JJ	JJ	_	31	amod	_	_
31	dishes	dish	NNS	NNS	_	28	nmod	_	_
32	for	for	IN	IN	_	36	case	_	_
33	an	a	DT	DT	_	36	det	_	_
34	additional	additional	JJ	JJ	_	36	amod	_	_
35	20	20	CD	CD	_	36	nummod	_	_
36	h	h	NN	NN	_	28	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	presence	presence	NN	NN	_	28	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	LPS	lps	NN	NN	_	39	nmod	_	_
42	or	or	CC	CC	_	41	cc	_	_
43	IL-1beta	il-1beta	NN	NN	_	41	conj	_	_
44	,	,	,	,	_	51	punct	_	_
45	an	a	DT	DT	_	47	det	_	_
46	enhanced	enhance	VBN	VBN	_	47	amod	_	_
47	release	release	NN	NN	_	51	nsubjpass	_	_
48	of	of	IN	IN	_	49	case	_	_
49	TNF	tnf	NN	NN	_	47	nmod	_	_
50	was	be	VBD	VBD	_	51	auxpass	_	_
51	observed	observe	VBN	VBN	_	0	root	_	_
52	.	.	.	.	_	51	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	was	be	VBD	VBD	_	5	cop	_	_
3	not	not	RB	RB	_	5	neg	_	_
4	the	the	DT	DT	_	5	det	_	_
5	case	case	NN	NN	_	0	root	_	_
6	when	when	WRB	WRB	_	9	advmod	_	_
7	PBMC	pbmc	NN	NN	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	aux	_	_
9	pre-cultured	pre-cultured	JJ	JJ	_	5	acl:relcl	_	_
10	in	in	IN	IN	_	12	case	_	_
11	plastic	plastic	JJ	JJ	_	12	amod	_	_
12	multidishes	multidish	NNS	NNS	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IL-10	il-10	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	TNF	tnf	NN	NN	_	3	compound	_	_
2	mRNA	mrna	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	8	nsubjpass	_	_
4	induced	induce	VBN	VBN	_	3	dep	_	_
5	by	by	IN	IN	_	6	case	_	_
6	LPS	lps	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	decreased	decrease	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	17	advmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	pre-treatment	pre-treatment	NN	NN	_	17	nsubjpass	_	_
12	of	of	IN	IN	_	13	case	_	_
13	PBMC	pbmc	NN	NN	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	IL-10	il-10	NN	NN	_	11	nmod	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	performed	perform	VBN	VBN	_	8	ccomp	_	_
18	on	on	IN	IN	_	19	case	_	_
19	plastic	plastic	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	whereas	whereas	IN	IN	_	8	dep	_	_
22	this	this	DT	DT	_	26	nsubj	_	_
23	was	be	VBD	VBD	_	26	cop	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	the	the	DT	DT	_	26	det	_	_
26	case	case	NN	NN	_	8	parataxis	_	_
27	when	when	WRB	WRB	_	30	advmod	_	_
28	cells	cell	NNS	NNS	_	30	nsubj	_	_
29	were	be	VBD	VBD	_	30	aux	_	_
30	pre-cultured	pre-cultured	JJ	JJ	_	26	acl:relcl	_	_
31	with	with	IN	IN	_	32	case	_	_
32	IL-10	il-10	NN	NN	_	30	nmod	_	_
33	on	on	IN	IN	_	34	case	_	_
34	Teflon	teflon	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	NFkappaB	nfkappab	NN	NN	_	4	compound	_	_
4	translocation	translocation	NN	NN	_	9	nsubj	_	_
5	following	follow	VBG	VBG	_	4	acl	_	_
6	LPS	lps	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	5	dobj	_	_
8	was	be	VBD	VBD	_	9	cop	_	_
9	higher	higher	JJR	JJR	_	0	root	_	_
10	after	after	IN	IN	_	12	case	_	_
11	IL-10	il-10	NN	NN	_	12	compound	_	_
12	pre-treatment	pre-treatment	NN	NN	_	9	nmod	_	_
13	on	on	IN	IN	_	14	case	_	_
14	Teflon	teflon	NN	NN	_	12	nmod	_	_
15	than	than	IN	IN	_	17	case	_	_
16	on	on	IN	IN	_	17	case	_	_
17	plastic	plastic	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Interestingly	interestingly	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	an	a	DT	DT	_	5	det	_	_
4	enhanced	enhance	VBN	VBN	_	5	amod	_	_
5	frequency	frequency	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	CD16	cd16	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	CD68(+)	cd68(+)	JJ	JJ	_	7	conj	_	_
10	cells	cell	NNS	NNS	_	7	dep	_	_
11	among	among	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	CD14(+)	cd14(+)	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	observed	observe	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	presence	presence	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IL-10	il-10	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	independently	independently	RB	RB	_	27	advmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	pre-culture	pre-culture	JJ	JJ	_	27	amod	_	_
27	conditions	condition	NNS	NNS	_	21	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	PBMC	pbmc	NN	NN	_	27	nmod	_	_
31	.	.	.	.	_	16	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-10-induced	il-10-induced	JJ	JJ	_	9	amod	_	_
9	up-regulation	up-regulation	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	nmod	_	_
13	depends	depend	VBZ	VBZ	_	5	ccomp	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	prevention	prevention	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	monocyte	monocyte	NN	NN	_	19	compound	_	_
19	adherence	adherence	NN	NN	_	16	nmod	_	_
20	by	by	IN	IN	_	22	case	_	_
21	red	red	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	in	in	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	whole	whole	JJ	JJ	_	27	amod	_	_
26	blood	blood	NN	NN	_	27	compound	_	_
27	assays	assay	NNS	NNS	_	22	nmod	_	_
28	or	or	CC	CC	_	22	cc	_	_
29	by	by	IN	IN	_	30	case	_	_
30	cultures	culture	NNS	NNS	_	22	conj	_	_
31	of	of	IN	IN	_	32	case	_	_
32	PBMC	pbmc	NN	NN	_	30	nmod	_	_
33	on	on	IN	IN	_	34	case	_	_
34	Teflon	teflon	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	the	the	DT	DT	_	6	det	_	_
5	adherence	adherence	NN	NN	_	6	compound	_	_
6	parameter	parameter	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	0	root	_	_
8	no	no	DT	DT	_	9	neg	_	_
9	effect	effect	NN	NN	_	7	dobj	_	_
10	on	on	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	IL-10-induced	il-10-induced	JJ	JJ	_	13	amod	_	_
13	modulation	modulation	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	some	some	DT	DT	_	18	det	_	_
16	monocyte	monocyte	NN	NN	_	18	compound	_	_
17	surface	surface	NN	NN	_	18	compound	_	_
18	markers	marker	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	4	case	_	_
4	RanBP1	ranbp1	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	release	release	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	CRM1	crm1	NN	NN	_	7	nmod	_	_
10	from	from	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	pore	pore	NN	NN	_	14	compound	_	_
14	complex	complex	NN	NN	_	7	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	terminal	terminal	JJ	JJ	_	18	amod	_	_
18	step	step	NN	NN	_	2	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	export	export	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	developed	develop	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	assay	assay	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	26	nmod	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	export	export	NN	NN	_	26	nsubjpass	_	_
10	of	of	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	shuttling	shuttle	VBG	VBG	_	15	amod	_	_
13	transcription	transcription	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	NFAT	nfat	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	22	punct	_	_
17	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
18	factor	factor	NN	NN	_	22	compound	_	_
19	of	of	IN	IN	_	22	amod	_	_
20	activated	activate	VBN	VBN	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	can	can	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	reconstituted	reconstitute	VBN	VBN	_	5	acl:relcl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	permeabilized	permeabilized	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	with	with	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	GTPase	gtpase	NN	NN	_	29	nmod	_	_
33	Ran	ran	NN	NN	_	32	dep	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	the	the	DT	DT	_	38	det	_	_
36	nuclear	nuclear	JJ	JJ	_	38	amod	_	_
37	export	export	NN	NN	_	38	compound	_	_
38	receptor	receptor	NN	NN	_	29	conj	_	_
39	CRM1	crm1	NN	NN	_	38	dep	_	_
40	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	this	this	DT	DT	_	6	det	_	_
6	assay	assay	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	identify	identify	VB	VB	_	6	acl	_	_
9	another	another	DT	DT	_	11	det	_	_
10	export	export	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	8	dobj	_	_
12	.	.	.	.	_	4	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	preincubation	preincubation	NN	NN	_	20	nmod	_	_
3	of	of	IN	IN	_	5	case	_	_
4	permeabilized	permeabilized	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	Ran	ran	NN	NN	_	9	compound	_	_
9	mutant	mutant	NN	NN	_	2	nmod	_	_
10	that	that	WDT	WDT	_	13	nsubj	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	hydrolyze	hydrolyze	VB	VB	_	9	acl:relcl	_	_
14	GTP	gtp	NN	NN	_	13	dobj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	RanQ69L	ranq69l	NN	NN	_	13	dep	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	20	punct	_	_
19	cytosol	cytosol	NN	NN	_	20	nsubj	_	_
20	supports	support	VBZ	VBZ	_	0	root	_	_
21	NFAT	nfat	NN	NN	_	22	compound	_	_
22	export	export	NN	NN	_	20	dobj	_	_
23	,	,	,	,	_	20	punct	_	_
24	but	but	CC	CC	_	20	cc	_	_
25	CRM1	crm1	NN	NN	_	29	nsubj	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	Ran	ran	NN	NN	_	25	conj	_	_
28	alone	alone	RB	RB	_	25	amod	_	_
29	do	do	VBP	VBP	_	20	conj	_	_
30	not	not	RB	RB	_	29	neg	_	_
31	.	.	.	.	_	20	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	RanQ69L	ranq69l	NN	NN	_	3	compound	_	_
3	preincubation	preincubation	NN	NN	_	0	root	_	_
4	leads	lead	VBZ	VBZ	_	3	dep	_	_
5	to	to	TO	TO	_	6	case	_	_
6	accumulation	accumulation	NN	NN	_	3	dep	_	_
7	of	of	IN	IN	_	8	case	_	_
8	CRM1	crm1	NN	NN	_	6	nmod	_	_
9	at	at	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
12	periphery	periphery	NN	NN	_	6	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
16	pore	pore	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	NPC	npc	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	in	in	IN	IN	_	22	case	_	_
22	association	association	NN	NN	_	6	nmod	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	dep	_	_
25	p62	p62	NN	NN	_	26	compound	_	_
26	complex	complex	NN	NN	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	Can/Nup214	can/nup214	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	3	punct	_	_

1	RanGTP-dependent	rangtp-dependent	JJ	JJ	_	2	amod	_	_
2	association	association	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CRM1	crm1	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	nucleoporins	nucleoporin	NNS	NNS	_	2	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	reconstituted	reconstitute	VBN	VBN	_	0	root	_	_
10	in	in	FW	FW	_	11	compound	_	_
11	vitro	vitro	FW	FW	_	9	advmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	By	by	IN	IN	_	3	case	_	_
2	biochemical	biochemical	JJ	JJ	_	3	amod	_	_
3	fractionation	fractionation	NN	NN	_	8	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	reconstitution	reconstitution	NN	NN	_	3	conj	_	_
6	,	,	,	,	_	8	punct	_	_
7	we	we	PRP	PRP	_	8	nsubj	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	11	mark	_	_
10	RanBP1	ranbp1	NN	NN	_	11	nsubj	_	_
11	restores	restore	VBZ	VBZ	_	8	ccomp	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	export	export	NN	NN	_	11	dobj	_	_
14	after	after	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	RanQ69L	ranq69l	NN	NN	_	17	compound	_	_
17	preincubation	preincubation	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	export	export	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	cells	cell	NNS	NNS	_	3	nmod	_	_
8	that	that	WDT	WDT	_	12	nsubjpass	_	_
9	have	have	VBP	VBP	_	12	aux	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	preincubated	preincubate	VBN	VBN	_	7	acl:relcl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	RanQ69L	ranq69l	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	RanBP1	ranbp1	NN	NN	_	6	compound	_	_
2	as	as	RB	RB	_	6	cc	_	_
3	well	well	RB	RB	_	2	mwe	_	_
4	as	as	IN	IN	_	2	mwe	_	_
5	Ran-binding	ran-binding	JJ	JJ	_	6	amod	_	_
6	domains	domain	NNS	NNS	_	12	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
10	nucleoporin	nucleoporin	NN	NN	_	6	nmod	_	_
11	RanBP2	ranbp2	NN	NN	_	10	dep	_	_
12	promote	promote	VBP	VBP	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	release	release	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CRM1	crm1	NN	NN	_	14	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	NPC	npc	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	indicate	indicate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	RanGTP	rangtp	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	important	important	JJ	JJ	_	6	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	targeting	targeting	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	export	export	NN	NN	_	16	compound	_	_
16	complexes	complex	NNS	NNS	_	13	nmod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cytoplasmic	cytoplasmic	JJ	JJ	_	20	amod	_	_
20	side	side	NN	NN	_	13	nmod	_	_
21	of	of	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	NPC	npc	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	10	cc	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	RanBP1	ranbp1	NN	NN	_	31	nsubjpass	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	probably	probably	RB	RB	_	29	advmod	_	_
29	RanBP2	ranbp2	NN	NN	_	26	conj	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	involved	involve	VBN	VBN	_	10	conj	_	_
32	in	in	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	dissociation	dissociation	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	nuclear	nuclear	JJ	JJ	_	38	amod	_	_
37	export	export	NN	NN	_	38	compound	_	_
38	complexes	complex	NNS	NNS	_	34	nmod	_	_
39	from	from	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	NPC	npc	NN	NN	_	34	nmod	_	_
42	in	in	IN	IN	_	47	case	_	_
43	a	a	DT	DT	_	47	det	_	_
44	terminal	terminal	JJ	JJ	_	47	amod	_	_
45	step	step	NN	NN	_	47	compound	_	_
46	of	of	IN	IN	_	47	amod	_	_
47	transport	transport	NN	NN	_	41	nmod	_	_
48	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Th1	th1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Th2	th2	NN	NN	_	3	conj	_	_
6	type	type	NN	NN	_	7	compound	_	_
7	cytokines	cytokine	NNS	NNS	_	3	dep	_	_
8	responding	respond	VBG	VBG	_	10	case	_	_
9	to	to	TO	TO	_	10	case	_	_
10	HBsAg	hbsag	NN	NN	_	1	acl	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	HBxAg	hbxag	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	17	case	_	_
14	chronic	chronic	JJ	JJ	_	17	amod	_	_
15	hepatitis	hepatitis	NN	NN	_	17	compound	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	1	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	cytokine	cytokine	NN	NN	_	3	compound	_	_
3	pattern	pattern	NN	NN	_	9	nsubjpass	_	_
4	on	on	IN	IN	_	7	case	_	_
5	viral	viral	JJ	JJ	_	7	amod	_	_
6	antigen	antigen	NN	NN	_	7	compound	_	_
7	recognition	recognition	NN	NN	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	believed	believe	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	exert	exert	VB	VB	_	9	xcomp	_	_
12	a	a	DT	DT	_	14	det	_	_
13	profound	profound	JJ	JJ	_	14	amod	_	_
14	influence	influence	NN	NN	_	11	dobj	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	resolution	resolution	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	viral	viral	JJ	JJ	_	20	amod	_	_
20	infections	infection	NNS	NNS	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	viral	viral	JJ	JJ	_	23	amod	_	_
23	clearance	clearance	NN	NN	_	20	conj	_	_
24	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	initiated	initiate	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	investigate	investigate	VB	VB	_	4	xcomp	_	_
7	whether	whether	IN	IN	_	16	mark	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cytokine	cytokine	NN	NN	_	10	compound	_	_
10	imbalance	imbalance	NN	NN	_	16	nsubj	_	_
11	oriented	orient	VBN	VBN	_	10	acl	_	_
12	toward	toward	IN	IN	_	15	case	_	_
13	Th2	th2	NN	NN	_	15	compound	_	_
14	type	type	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	plays	play	VBZ	VBZ	_	6	ccomp	_	_
17	a	a	DT	DT	_	18	det	_	_
18	role	role	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	chronic	chronic	JJ	JJ	_	22	amod	_	_
21	hepatitis	hepatitis	NN	NN	_	22	compound	_	_
22	B	b	NN	NN	_	16	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Cytokine	cytokine	NN	NN	_	2	compound	_	_
2	profiles	profile	NNS	NNS	_	14	nsubjpass	_	_
3	of	of	IN	IN	_	7	case	_	_
4	peripheral	peripheral	JJ	JJ	_	7	amod	_	_
5	blood	blood	NN	NN	_	7	compound	_	_
6	mononuclear	mononuclear	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	2	nmod	_	_
8	associated	associate	VBN	VBN	_	7	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	chronic	chronic	JJ	JJ	_	12	amod	_	_
11	hepatitis	hepatitis	NN	NN	_	12	compound	_	_
12	B	b	NN	NN	_	8	nmod	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	analysed	analyse	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	RT-PCR	rt-pcr	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	14	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	HBsAg	hbsag	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	expression	expression	NN	NN	_	16	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	IL-2	il-2	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	IL-4	il-4	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	IL-10	il-10	NN	NN	_	7	conj	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	detected	detect	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	41	41	CD	CD	_	19	nummod	_	_
19	%	%	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	8	8	CD	CD	_	22	nummod	_	_
22	%	%	NN	NN	_	19	conj	_	_
23	,	,	,	,	_	19	punct	_	_
24	41	41	CD	CD	_	25	nummod	_	_
25	%	%	NN	NN	_	19	conj	_	_
26	,	,	,	,	_	19	punct	_	_
27	and	and	CC	CC	_	19	cc	_	_
28	50	50	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	19	conj	_	_
30	of	of	IN	IN	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	patients	patient	NNS	NNS	_	19	nmod	_	_
33	,	,	,	,	_	16	punct	_	_
34	respectively	respectively	RB	RB	_	16	advmod	_	_
35	.	.	.	.	_	16	punct	_	_

1	Among	among	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	cytokines	cytokine	NNS	NNS	_	10	nmod	_	_
4	,	,	,	,	_	10	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	expression	expression	NN	NN	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	high	high	JJ	JJ	_	13	amod	_	_
13	levels	level	NNS	NNS	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	serum	serum	NN	NN	_	16	compound	_	_
16	AST/ALT	ast/alt	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	we	we	PRP	PRP	_	6	nsubj	_	_
4	could	could	MD	MD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	prove	prove	VB	VB	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	Th2	th2	NN	NN	_	10	compound	_	_
9	type	type	NN	NN	_	10	compound	_	_
10	cytokines	cytokine	NNS	NNS	_	11	nsubj	_	_
11	had	have	VBD	VBD	_	6	ccomp	_	_
12	a	a	DT	DT	_	14	det	_	_
13	protective	protective	JJ	JJ	_	14	amod	_	_
14	effect	effect	NN	NN	_	11	dobj	_	_
15	on	on	IN	IN	_	16	case	_	_
16	hepatocytes	hepatocyte	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	6	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	HBxAg	hbxag	NN	NN	_	3	compound	_	_
3	stimulation	stimulation	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	there	there	EX	EX	_	6	expl	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	no	no	DT	DT	_	9	neg	_	_
8	recognizable	recognizable	JJ	JJ	_	9	amod	_	_
9	association	association	NN	NN	_	6	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	cytokine	cytokine	NN	NN	_	12	compound	_	_
12	patterns	pattern	NNS	NNS	_	9	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	AST/ALT	ast/alt	NN	NN	_	15	compound	_	_
15	levels	level	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	16	nmod	_	_
3	,	,	,	,	_	16	punct	_	_
4	production	production	NN	NN	_	16	nsubjpass	_	_
5	of	of	IN	IN	_	10	case	_	_
6	a	a	DT	DT	_	10	det	_	_
7	Th1	th1	NN	NN	_	10	compound	_	_
8	cytokine	cytokine	NN	NN	_	10	compound	_	_
9	,	,	,	,	_	10	punct	_	_
10	IFN-gamma	ifn-gamma	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	4	punct	_	_
12	by	by	IN	IN	_	14	case	_	_
13	HBsAg-reactive	hbsag-reactive	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	4	nmod	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	19	case	_	_
18	hepatocyte	hepatocyte	NN	NN	_	19	compound	_	_
19	damage	damage	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	chronic	chronic	JJ	JJ	_	23	amod	_	_
22	hepatitis	hepatitis	NN	NN	_	23	compound	_	_
23	B	b	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	16	punct	_	_
25	while	while	IN	IN	_	37	mark	_	_
26	no	no	DT	DT	_	28	neg	_	_
27	counteracting	counteracting	NN	NN	_	28	compound	_	_
28	effect	effect	NN	NN	_	37	nsubjpass	_	_
29	of	of	IN	IN	_	31	case	_	_
30	Th2	th2	NN	NN	_	31	compound	_	_
31	cytokines	cytokine	NNS	NNS	_	28	nmod	_	_
32	produced	produce	VBN	VBN	_	31	acl	_	_
33	by	by	IN	IN	_	35	case	_	_
34	those	those	DT	DT	_	35	det	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	was	be	VBD	VBD	_	37	auxpass	_	_
37	observed	observe	VBN	VBN	_	16	advcl	_	_
38	.	.	.	.	_	16	punct	_	_

1	Different	different	JJ	JJ	_	3	amod	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	requirements	requirement	NNS	NNS	_	0	root	_	_
4	for	for	IN	IN	_	5	case	_	_
5	expression	expression	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	10	case	_	_
7	erythroid	erythroid	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	megakaryocytic	megakaryocytic	JJ	JJ	_	7	conj	_	_
10	cells	cell	NNS	NNS	_	5	nmod	_	_
11	within	within	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	regulatory	regulatory	JJ	JJ	_	14	amod	_	_
14	element	element	NN	NN	_	10	nmod	_	_
15	upstream	upstream	JJ	JJ	_	14	amod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	GATA-1	gata-1	NN	NN	_	19	compound	_	_
19	gene	gene	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	lineage-restricted	lineage-restricted	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	7	nsubjpass	_	_
5	GATA-1	gata-1	NN	NN	_	4	dep	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	differentiation	differentiation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	erythroid	erythroid	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	megakaryocytic	megakaryocytic	JJ	JJ	_	11	conj	_	_
14	cells	cell	NNS	NNS	_	9	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	localized	localize	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	10	det	_	_
5	317	317	CD	CD	_	10	nummod	_	_
6	base	base	NN	NN	_	10	compound	_	_
7	pair	pair	NN	NN	_	10	compound	_	_
8	cis-acting	cis-acting	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	element	element	NN	NN	_	3	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	HS	hs	NN	NN	_	10	appos	_	_
13	I	i	CD	CD	_	12	nummod	_	_
14	,	,	,	,	_	10	punct	_	_
15	associated	associate	VBN	VBN	_	10	acl	_	_
16	with	with	IN	IN	_	22	case	_	_
17	a	a	DT	DT	_	22	det	_	_
18	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	22	amod	_	_
19	DNase	dnase	NN	NN	_	22	compound	_	_
20	I	i	CD	CD	_	22	nummod	_	_
21	hypersensitive	hypersensitive	JJ	JJ	_	22	amod	_	_
22	site	site	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	lies	lie	VBZ	VBZ	_	22	acl:relcl	_	_
26	approx.	approx.	RB	RB	_	27	advmod	_	_
27	3.7	3.7	CD	CD	_	28	nummod	_	_
28	kilobases	kilobase	NNS	NNS	_	29	nmod:npmod	_	_
29	upstream	upstream	RB	RB	_	25	advmod	_	_
30	of	of	IN	IN	_	36	case	_	_
31	the	the	DT	DT	_	36	det	_	_
32	murine	murine	JJ	JJ	_	36	amod	_	_
33	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	36	amod	_	_
34	GATA-1	gata-1	NN	NN	_	36	compound	_	_
35	IE	ie	NN	NN	_	36	compound	_	_
36	promoter	promoter	NN	NN	_	29	nmod	_	_
37	.	.	.	.	_	3	punct	_	_

1	HS	hs	NN	NN	_	3	nsubj	_	_
2	I	i	CD	CD	_	1	nummod	_	_
3	directs	direct	VBZ	VBZ	_	0	root	_	_
4	high-level	high-level	JJ	JJ	_	5	amod	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	reporter	reporter	NN	NN	_	9	compound	_	_
8	GATA-1/lacZ	gata-1/lacz	NN	NN	_	9	compound	_	_
9	genes	gene	NNS	NNS	_	5	nmod	_	_
10	to	to	TO	TO	_	15	case	_	_
11	primitive	primitive	JJ	JJ	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	definitive	definitive	JJ	JJ	_	11	conj	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	3	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	megakaryocytes	megakaryocyte	NNS	NNS	_	15	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	transgenic	transgenic	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Comparative	comparative	JJ	JJ	_	3	amod	_	_
2	sequence	sequence	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	HS	hs	NN	NN	_	3	nmod	_	_
6	I	i	CD	CD	_	5	nummod	_	_
7	between	between	IN	IN	_	8	case	_	_
8	human	human	JJ	JJ	_	3	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	mouse	mouse	NN	NN	_	8	conj	_	_
11	shows	show	VBZ	VBZ	_	0	root	_	_
12	approx.	approx.	RB	RB	_	13	advmod	_	_
13	63	63	CD	CD	_	16	nummod	_	_
14	%	%	NN	NN	_	16	compound	_	_
15	nucleotide	nucleotide	NN	NN	_	16	compound	_	_
16	identity	identity	NN	NN	_	11	dobj	_	_
17	with	with	IN	IN	_	21	case	_	_
18	a	a	DT	DT	_	21	det	_	_
19	more	more	RBR	RBR	_	20	advmod	_	_
20	conserved	conserve	VBN	VBN	_	21	amod	_	_
21	core	core	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	169	169	CD	CD	_	25	nummod	_	_
24	base	base	NN	NN	_	25	compound	_	_
25	pairs	pair	NNS	NNS	_	21	nmod	_	_
26	(	(	-LRB-	-LRB-	_	29	punct	_	_
27	86	86	CD	CD	_	29	nummod	_	_
28	%	%	NN	NN	_	29	compound	_	_
29	identity	identity	NN	NN	_	21	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	11	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	core	core	NN	NN	_	3	nsubj	_	_
3	contains	contain	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	GATA	gata	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	3	dobj	_	_
7	separated	separate	VBN	VBN	_	6	acl	_	_
8	by	by	IN	IN	_	11	case	_	_
9	10	10	CD	CD	_	11	nummod	_	_
10	base	base	NN	NN	_	11	compound	_	_
11	pairs	pair	NNS	NNS	_	7	nmod	_	_
12	from	from	IN	IN	_	15	case	_	_
13	an	a	DT	DT	_	15	det	_	_
14	E-box	e-box	NN	NN	_	15	compound	_	_
15	motif	motif	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	composite	composite	JJ	JJ	_	3	amod	_	_
3	motif	motif	NN	NN	_	4	nsubj	_	_
4	binds	bind	VBZ	VBZ	_	0	root	_	_
5	a	a	DT	DT	_	10	det	_	_
6	multi-protein	multi-protein	JJ	JJ	_	10	amod	_	_
7	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	10	amod	_	_
8	transcription	transcription	NN	NN	_	10	compound	_	_
9	factor	factor	NN	NN	_	10	compound	_	_
10	complex	complex	NN	NN	_	4	dobj	_	_
11	which	which	WDT	WDT	_	12	nsubj	_	_
12	includes	include	VBZ	VBZ	_	10	acl:relcl	_	_
13	GATA-1	gata-1	NN	NN	_	12	dobj	_	_
14	,	,	,	,	_	13	punct	_	_
15	SCL/tal-1	scl/tal-1	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	E2A	e2a	NN	NN	_	13	conj	_	_
18	,	,	,	,	_	13	punct	_	_
19	Lmo2	lmo2	NN	NN	_	13	conj	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	Ldb-1	ldb-1	NN	NN	_	13	conj	_	_
22	.	.	.	.	_	4	punct	_	_

1	Point	point	JJ	JJ	_	2	amod	_	_
2	mutations	mutation	NNS	NNS	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	GATA	gata	NN	NN	_	6	compound	_	_
6	site	site	NN	NN	_	2	nmod	_	_
7	abolishes	abolish	VBZ	VBZ	_	0	root	_	_
8	HS	h	NNS	NNS	_	10	compound	_	_
9	I	i	CD	CD	_	10	nummod	_	_
10	function	function	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	7	punct	_	_
12	whereas	whereas	IN	IN	_	7	dep	_	_
13	mutation	mutation	NN	NN	_	19	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	E-box	e-box	NN	NN	_	17	compound	_	_
17	motif	motif	NN	NN	_	13	nmod	_	_
18	still	still	RB	RB	_	19	advmod	_	_
19	allows	allow	VBZ	VBZ	_	7	parataxis	_	_
20	reporter	reporter	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	both	both	DT	DT	_	25	det	_	_
25	lineages	lineage	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Strict	strict	JJ	JJ	_	2	amod	_	_
2	dependence	dependence	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	HS	hs	NN	NN	_	6	compound	_	_
5	I	i	CD	CD	_	6	nummod	_	_
6	activity	activity	NN	NN	_	2	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	GATA	gata	NN	NN	_	10	compound	_	_
10	site	site	NN	NN	_	2	nmod	_	_
11	implies	imply	VBZ	VBZ	_	0	root	_	_
12	that	that	IN	IN	_	28	mark	_	_
13	assembly	assembly	NN	NN	_	28	nsubj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	protein	protein	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	13	nmod	_	_
18	containing	contain	VBG	VBG	_	17	acl	_	_
19	a	a	DT	DT	_	20	det	_	_
20	GATA-factor	gata-factor	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	20	punct	_	_
22	presumably	presumably	RB	RB	_	23	advmod	_	_
23	GATA-1	gata-1	NN	NN	_	20	appos	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	GATA-2	gata-2	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	28	punct	_	_
27	is	be	VBZ	VBZ	_	28	cop	_	_
28	critical	critical	JJ	JJ	_	11	ccomp	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	activating	activate	VBG	VBG	_	28	advcl	_	_
31	or	or	CC	CC	_	30	cc	_	_
32	maintaining	maintain	VBG	VBG	_	30	conj	_	_
33	its	its	PRP$	PRP$	_	34	nmod:poss	_	_
34	function	function	NN	NN	_	30	dobj	_	_
35	.	.	.	.	_	11	punct	_	_

1	Further	further	RB	RB	_	2	advmod	_	_
2	dissection	dissection	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	the	the	DT	DT	_	8	det	_	_
5	317	317	CD	CD	_	8	nummod	_	_
6	base	base	NN	NN	_	8	compound	_	_
7	pair	pair	NN	NN	_	8	compound	_	_
8	region	region	NN	NN	_	2	nmod	_	_
9	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
10	that	that	IN	IN	_	31	mark	_	_
11	,	,	,	,	_	31	punct	_	_
12	whereas	whereas	IN	IN	_	18	mark	_	_
13	all	all	DT	DT	_	16	det	_	_
14	317	317	CD	CD	_	16	nummod	_	_
15	base	base	NN	NN	_	16	compound	_	_
16	pairs	pair	NNS	NNS	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	31	advcl	_	_
19	for	for	IN	IN	_	20	case	_	_
20	expression	expression	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	megakaryocytes	megakaryocyte	NNS	NNS	_	20	nmod	_	_
23	,	,	,	,	_	31	punct	_	_
24	only	only	RB	RB	_	29	advmod	_	_
25	the	the	DT	DT	_	29	det	_	_
26	5'	5'	JJ	JJ	_	29	amod	_	_
27	62	62	CD	CD	_	29	nummod	_	_
28	base	base	NN	NN	_	29	compound	_	_
29	pairs	pair	NNS	NNS	_	31	nsubjpass	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	needed	need	VBN	VBN	_	9	ccomp	_	_
32	for	for	IN	IN	_	35	case	_	_
33	erythroid-specific	erythroid-specific	JJ	JJ	_	35	amod	_	_
34	reporter	reporter	NN	NN	_	35	compound	_	_
35	expression	expression	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	differential	differential	JJ	JJ	_	6	amod	_	_
5	lineage	lineage	NN	NN	_	6	compound	_	_
6	requirements	requirement	NNS	NNS	_	3	dobj	_	_
7	for	for	IN	IN	_	8	case	_	_
8	expression	expression	NN	NN	_	6	nmod	_	_
9	within	within	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	HS	hs	NN	NN	_	13	compound	_	_
12	I	i	CD	CD	_	13	nummod	_	_
13	element	element	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Monocyte	monocyte	NN	NN	_	2	compound	_	_
2	arrest	arrest	NN	NN	_	12	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	transmigration	transmigration	NN	NN	_	2	conj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	inflamed	inflamed	JJ	JJ	_	7	amod	_	_
7	endothelium	endothelium	NN	NN	_	2	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	shear	shear	NN	NN	_	10	compound	_	_
10	flow	flow	NN	NN	_	2	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	adenovirus-mediated	adenovirus-mediated	JJ	JJ	_	16	amod	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	transfer	transfer	NN	NN	_	12	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	IkappaB-alpha	ikappab-alpha	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	Mobilization	mobilization	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	factor-kappaB	factor-kappab	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	activates	activate	VBZ	VBZ	_	0	root	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	genes	gene	NNS	NNS	_	9	nmod	_	_
12	encoding	encode	VBG	VBG	_	11	acl	_	_
13	endothelial	endothelial	JJ	JJ	_	15	amod	_	_
14	adhesion	adhesion	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	chemokines	chemokine	NNS	NNS	_	15	conj	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	contribute	contribute	VBP	VBP	_	11	acl:relcl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	monocyte	monocyte	NN	NN	_	22	compound	_	_
22	infiltration	infiltration	NN	NN	_	19	nmod	_	_
23	critical	critical	JJ	JJ	_	22	amod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	atherogenesis	atherogenesis	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	6	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	1	nmod	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	achieved	achieve	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	11	case	_	_
8	pharmacological	pharmacological	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	genetic	genetic	JJ	JJ	_	8	conj	_	_
11	approaches	approach	NNS	NNS	_	6	nmod	_	_
12	;	;	:	:	_	6	punct	_	_
13	however	however	RB	RB	_	6	advmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	monocyte	monocyte	NN	NN	_	16	compound	_	_
16	interactions	interaction	NNS	NNS	_	34	nsubjpass	_	_
17	with	with	IN	IN	_	19	case	_	_
18	activated	activate	VBN	VBN	_	19	amod	_	_
19	endothelium	endothelium	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	shear	shear	NN	NN	_	22	compound	_	_
22	flow	flow	NN	NN	_	16	nmod	_	_
23	following	follow	VBG	VBG	_	25	case	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transfer	transfer	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	29	compound	_	_
29	inhibitor	inhibitor	NN	NN	_	25	nmod	_	_
30	IkappaB-alpha	ikappab-alpha	NN	NN	_	29	dep	_	_
31	have	have	VBP	VBP	_	34	aux	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	been	be	VBN	VBN	_	34	auxpass	_	_
34	studied	study	VBN	VBN	_	6	dep	_	_
35	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	14	mark	_	_
4	overexpression	overexpression	NN	NN	_	14	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IkappaB-alpha	ikappab-alpha	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	using	use	VBG	VBG	_	4	dep	_	_
11	a	a	DT	DT	_	13	det	_	_
12	recombinant	recombinant	JJ	JJ	_	13	amod	_	_
13	adenovirus	adenovirus	NN	NN	_	10	dobj	_	_
14	prevented	prevent	VBD	VBD	_	2	ccomp	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	necrosis	necrosis	NN	NN	_	17	compound	_	_
17	factor-alpha	factor-alpha	NN	NN	_	22	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	-induced	-induced	JJ	JJ	_	22	amod	_	_
22	degradation	degradation	NN	NN	_	14	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IkappaB-alpha	ikappab-alpha	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	14	cc	_	_
26	suppressed	suppress	VBD	VBD	_	14	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	upregulation	upregulation	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	vascular	vascular	JJ	JJ	_	33	amod	_	_
31	cell	cell	NN	NN	_	33	compound	_	_
32	adhesion	adhesion	NN	NN	_	33	compound	_	_
33	molecule-1	molecule-1	NN	NN	_	28	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	VCAM-1	vcam-1	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	,	,	,	,	_	33	punct	_	_
38	intercellular	intercellular	JJ	JJ	_	40	amod	_	_
39	adhesion	adhesion	NN	NN	_	40	compound	_	_
40	molecule-1	molecule-1	NN	NN	_	33	conj	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	ICAM-1	icam-1	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	,	,	,	,	_	33	punct	_	_
45	and	and	CC	CC	_	33	cc	_	_
46	E-selectin	e-selectin	NN	NN	_	47	compound	_	_
47	mRNA	mrna	NN	NN	_	33	conj	_	_
48	and	and	CC	CC	_	33	cc	_	_
49	surface	surface	NN	NN	_	51	compound	_	_
50	protein	protein	NN	NN	_	51	compound	_	_
51	expression	expression	NN	NN	_	33	conj	_	_
52	and	and	CC	CC	_	28	cc	_	_
53	the	the	DT	DT	_	54	det	_	_
54	upregulation	upregulation	NN	NN	_	28	conj	_	_
55	of	of	IN	IN	_	56	case	_	_
56	transcripts	transcript	NNS	NNS	_	54	nmod	_	_
57	for	for	IN	IN	_	59	case	_	_
58	the	the	DT	DT	_	59	det	_	_
59	chemokines	chemokine	NNS	NNS	_	56	nmod	_	_
60	monocyte	monocyte	NN	NN	_	62	compound	_	_
61	chemoattractant	chemoattractant	NN	NN	_	62	compound	_	_
62	protein	protein	NN	NN	_	59	dep	_	_
63	1	1	CD	CD	_	62	nummod	_	_
64	(	(	-LRB-	-LRB-	_	65	punct	_	_
65	MCP-1	mcp-1	NN	NN	_	62	appos	_	_
66	)	)	-RRB-	-RRB-	_	65	punct	_	_
67	and	and	CC	CC	_	59	cc	_	_
68	growth-related	growth-related	JJ	JJ	_	69	amod	_	_
69	activity-alpha	activity-alpha	NN	NN	_	59	conj	_	_
70	(	(	-LRB-	-LRB-	_	71	punct	_	_
71	GRO-alpha	gro-alpha	NN	NN	_	69	appos	_	_
72	)	)	-RRB-	-RRB-	_	71	punct	_	_
73	by	by	IN	IN	_	74	case	_	_
74	TNF-alpha	tnf-alpha	NN	NN	_	56	nmod	_	_
75	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	associated	associate	VBN	VBN	_	0	root	_	_
4	with	with	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	reduction	reduction	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
9	MCP-1	mcp-1	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	GRO-alpha	gro-alpha	NN	NN	_	13	compound	_	_
13	immobilization	immobilization	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Adhesion	adhesion	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	8	nsubj	_	_
3	under	under	IN	IN	_	7	case	_	_
4	physiological	physiological	JJ	JJ	_	7	amod	_	_
5	shear	shear	NN	NN	_	7	compound	_	_
6	flow	flow	NN	NN	_	7	compound	_	_
7	conditions	condition	NNS	NNS	_	2	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	24	mark	_	_
10	firm	firm	JJ	JJ	_	11	amod	_	_
11	arrest	arrest	NN	NN	_	24	nsubjpass	_	_
12	,	,	,	,	_	11	punct	_	_
13	spreading	spreading	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	transmigration	transmigration	NN	NN	_	11	conj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
19	on	on	IN	IN	_	21	case	_	_
20	TNF-alpha-activated	tnf-alpha-activated	JJ	JJ	_	21	case	_	_
21	endothelium	endothelium	NN	NN	_	11	acl	_	_
22	was	be	VBD	VBD	_	24	auxpass	_	_
23	markedly	markedly	RB	RB	_	24	advmod	_	_
24	inhibited	inhibit	VBN	VBN	_	8	ccomp	_	_
25	by	by	IN	IN	_	27	case	_	_
26	IkappaB-alpha	ikappab-alpha	NN	NN	_	27	compound	_	_
27	overexpression	overexpression	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	8	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	monoclonal	monoclonal	JJ	JJ	_	4	amod	_	_
4	antibodies	antibody	NNS	NNS	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	peptide	peptide	NN	NN	_	7	compound	_	_
7	antagonists	antagonist	NNS	NNS	_	4	conj	_	_
8	inferred	infer	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	15	mark	_	_
10	this	this	DT	DT	_	15	nsubj	_	_
11	was	be	VBD	VBD	_	15	cop	_	_
12	due	due	JJ	JJ	_	15	case	_	_
13	to	to	TO	TO	_	12	mwe	_	_
14	reduced	reduce	VBN	VBN	_	15	amod	_	_
15	expression	expression	NN	NN	_	8	ccomp	_	_
16	of	of	IN	IN	_	19	case	_	_
17	Ig	ig	NN	NN	_	19	compound	_	_
18	integrin	integrin	NN	NN	_	19	compound	_	_
19	ligand	ligand	NN	NN	_	15	nmod	_	_
20	as	as	RB	RB	_	19	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	of	of	IN	IN	_	24	case	_	_
24	chemokines	chemokine	NNS	NNS	_	19	conj	_	_
25	specifically	specifically	RB	RB	_	26	advmod	_	_
26	involved	involve	VBN	VBN	_	24	dep	_	_
27	in	in	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	events	event	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	rolling	rolling	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	increased	increase	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	IkappaB-alpha	ikappab-alpha	NN	NN	_	11	compound	_	_
11	transfer	transfer	NN	NN	_	8	nmod	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	partly	partly	RB	RB	_	15	advmod	_	_
15	mediated	mediate	VBN	VBN	_	8	conj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	P-selectin	p-selectin	NN	NN	_	15	nmod	_	_
18	;	;	:	:	_	8	punct	_	_
19	however	however	RB	RB	_	8	advmod	_	_
20	,	,	,	,	_	8	punct	_	_
21	it	it	PRP	PRP	_	22	nsubj	_	_
22	appeared	appear	VBD	VBD	_	8	dep	_	_
23	to	to	TO	TO	_	25	mark	_	_
24	be	be	VB	VB	_	25	aux	_	_
25	unaffected	unaffected	JJ	JJ	_	22	xcomp	_	_
26	by	by	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	inhibition	inhibition	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	E-selectin	e-selectin	NN	NN	_	31	compound	_	_
31	induction	induction	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	novel	novel	JJ	JJ	_	7	amod	_	_
7	evidence	evidence	NN	NN	_	5	dobj	_	_
8	that	that	IN	IN	_	18	mark	_	_
9	selective	selective	JJ	JJ	_	10	amod	_	_
10	modulation	modulation	NN	NN	_	18	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	nmod	_	_
13	by	by	IN	IN	_	15	case	_	_
14	adenoviral	adenoviral	JJ	JJ	_	15	amod	_	_
15	transfer	transfer	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	IkappaB-alpha	ikappab-alpha	NN	NN	_	15	nmod	_	_
18	impairs	impair	VBZ	VBZ	_	7	dep	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	multiple	multiple	JJ	JJ	_	25	amod	_	_
23	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	products	product	NNS	NNS	_	20	nmod	_	_
26	required	require	VBN	VBN	_	20	acl	_	_
27	for	for	IN	IN	_	30	case	_	_
28	subsequent	subsequent	JJ	JJ	_	30	amod	_	_
29	monocyte	monocyte	NN	NN	_	30	compound	_	_
30	arrest	arrest	NN	NN	_	26	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	emigration	emigration	NN	NN	_	30	conj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	shear	shear	NN	NN	_	35	compound	_	_
35	flow	flow	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	30	cc	_	_
37	thus	thus	RB	RB	_	40	advmod	_	_
38	for	for	IN	IN	_	40	case	_	_
39	monocyte	monocyte	NN	NN	_	40	compound	_	_
40	infiltration	infiltration	NN	NN	_	30	conj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	atherosclerotic	atherosclerotic	JJ	JJ	_	43	amod	_	_
43	plaques	plaque	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	14	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	c-Akt	c-akt	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	phosphatidylinositol	phosphatidylinositol	NN	NN	_	9	compound	_	_
9	3-kinase	3-kinase	NN	NN	_	3	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	and	and	CC	CC	_	3	cc	_	_
12	STAT5	stat5	NN	NN	_	3	conj	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	activated	activate	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	erythropoietin	erythropoietin	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	EPO	epo	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	in	in	IN	IN	_	23	case	_	_
21	HCD57	hcd57	NN	NN	_	23	compound	_	_
22	erythroid	erythroid	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	but	but	CC	CC	_	14	cc	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	constitutively	constitutively	RB	RB	_	27	advmod	_	_
27	active	active	JJ	JJ	_	14	conj	_	_
28	in	in	IN	IN	_	33	case	_	_
29	an	a	DT	DT	_	33	det	_	_
30	EPO-independent	epo-independent	JJ	JJ	_	33	amod	_	_
31	,	,	,	,	_	33	punct	_	_
32	apoptosis-resistant	apoptosis-resistant	JJ	JJ	_	33	amod	_	_
33	subclone	subclone	NN	NN	_	27	nmod	_	_
34	(	(	-LRB-	-LRB-	_	36	punct	_	_
35	HCD57-SREI	hcd57-srei	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	33	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	15	mark	_	_
4	erythropoietin	erythropoietin	NN	NN	_	15	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EPO	epo	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	stem	stem	VBP	VBP	_	11	dep	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	SCF	scf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	activated	activate	VBD	VBD	_	2	ccomp	_	_
16	protein	protein	NN	NN	_	18	compound	_	_
17	kinase	kinase	NN	NN	_	18	compound	_	_
18	B	b	NN	NN	_	15	dobj	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	PKB/Akt	pkb/akt	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	in	in	IN	IN	_	26	case	_	_
23	EPO-dependent	epo-dependent	JJ	JJ	_	26	amod	_	_
24	HCD57	hcd57	NN	NN	_	26	compound	_	_
25	erythroid	erythroid	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	understand	understand	VB	VB	_	21	advcl	_	_
4	signals	signal	NNS	NNS	_	6	compound	_	_
5	controlling	control	VBG	VBG	_	6	amod	_	_
6	proliferation	proliferation	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	viability	viability	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	21	punct	_	_
10	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	21	nsubjpass	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	resist	resist	VBP	VBP	_	11	acl:relcl	_	_
14	apoptosis	apoptosis	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	absence	absence	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	EPO	epo	NN	NN	_	17	nmod	_	_
20	were	be	VBD	VBD	_	21	auxpass	_	_
21	subcloned	subclon	VBN	VBN	_	0	root	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	characterized	characterize	VBN	VBN	_	21	conj	_	_
24	(	(	-LRB-	-LRB-	_	26	punct	_	_
25	HCD57-SREI	hcd57-srei	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	21	dep	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	21	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	2	amod	_	_
2	activations	activation	NNS	NNS	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	PKB/Akt	pkb/akt	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	STAT5a	stat5a	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	STAT5b	stat5b	NN	NN	_	4	conj	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	noted	note	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	15	case	_	_
13	these	these	DT	DT	_	15	det	_	_
14	EPO-independent	epo-independent	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	PI3-kinase	pi3-kinase	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	6	nsubj	_	_
3	was	be	VBD	VBD	_	6	cop	_	_
4	an	a	DT	DT	_	6	det	_	_
5	upstream	upstream	JJ	JJ	_	6	amod	_	_
6	activator	activator	NN	NN	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PKB/Akt	pkb/akt	NN	NN	_	6	nmod	_	_
9	because	because	IN	IN	_	14	mark	_	_
10	the	the	DT	DT	_	12	det	_	_
11	PI3-kinase	pi3-kinase	NN	NN	_	12	compound	_	_
12	inhibitor	inhibitor	NN	NN	_	14	nsubj	_	_
13	LY294002	ly294002	NN	NN	_	12	dep	_	_
14	blocked	block	VBD	VBD	_	6	advcl	_	_
15	both	both	CC	CC	_	17	cc:preconj	_	_
16	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
17	PKB/Akt	pkb/akt	NN	NN	_	14	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	factor-dependent	factor-dependent	JJ	JJ	_	21	amod	_	_
20	PKB/Akt	pkb/akt	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	LY294002	ly294002	NN	NN	_	3	compound	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	proliferation	proliferation	NN	NN	_	15	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	viability	viability	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	HCD57-SREI	hcd57-srei	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	HCD57	hcd57	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	correlated	correlate	VBD	VBD	_	4	ccomp	_	_
16	with	with	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	PKB/Akt	pkb/akt	NN	NN	_	18	nmod	_	_
21	;	;	:	:	_	15	punct	_	_
22	however	however	RB	RB	_	15	advmod	_	_
23	,	,	,	,	_	15	punct	_	_
24	PKB/Akt	pkb/akt	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	29	nsubj	_	_
26	alone	alone	RB	RB	_	25	amod	_	_
27	did	do	VBD	VBD	_	29	aux	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	protect	protect	VB	VB	_	15	dep	_	_
30	these	these	DT	DT	_	31	det	_	_
31	cells	cell	NNS	NNS	_	29	dobj	_	_
32	from	from	IN	IN	_	33	case	_	_
33	apoptosis	apoptosis	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	Treatment	treatment	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	HCD57	hcd57	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	SCF	scf	NN	NN	_	1	nmod	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	activated	activate	VBD	VBD	_	0	root	_	_
9	PKB/Akt	pkb/akt	NN	NN	_	8	dobj	_	_
10	,	,	,	,	_	8	punct	_	_
11	but	but	CC	CC	_	8	cc	_	_
12	did	do	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	protect	protect	VB	VB	_	8	conj	_	_
15	from	from	IN	IN	_	16	case	_	_
16	apoptosis	apoptosis	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	suggested	suggest	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	PKB/PI3-kinase	pkb/pi3-kinase	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	8	nsubj	_	_
7	is	be	VBZ	VBZ	_	8	cop	_	_
8	necessary	necessary	JJ	JJ	_	3	ccomp	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	not	not	RB	RB	_	8	conj	_	_
11	sufficient	sufficient	JJ	JJ	_	8	dep	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	promote	promote	VB	VB	_	11	xcomp	_	_
14	viability	viability	NN	NN	_	13	dobj	_	_
15	and/or	and/or	CC	CC	_	14	cc	_	_
16	proliferation	proliferation	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	STAT5	stat5	NN	NN	_	3	compound	_	_
3	activity	activity	NN	NN	_	17	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	activated	activate	VBN	VBN	_	3	acl	_	_
6	through	through	IN	IN	_	9	case	_	_
7	an	a	DT	DT	_	9	det	_	_
8	unknown	unknown	JJ	JJ	_	9	amod	_	_
9	pathway	pathway	NN	NN	_	5	nmod	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	including	include	VBG	VBG	_	9	acl	_	_
12	JAK2	jak2	NN	NN	_	11	dobj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	EPOR	epor	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	17	punct	_	_
16	may	may	MD	MD	_	17	aux	_	_
17	act	act	VB	VB	_	0	root	_	_
18	in	in	IN	IN	_	19	case	_	_
19	concert	concert	NN	NN	_	17	nmod	_	_
20	with	with	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	constitutive	constitutive	JJ	JJ	_	24	amod	_	_
23	PI3-kinase/PKB/Akt	pi3-kinase/pkb/akt	NN	NN	_	24	compound	_	_
24	pathway	pathway	NN	NN	_	19	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	protect	protect	VB	VB	_	17	xcomp	_	_
27	the	the	DT	DT	_	30	det	_	_
28	EPO-independent	epo-independent	JJ	JJ	_	30	amod	_	_
29	HCD57-SREI	hcd57-srei	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	dobj	_	_
31	from	from	IN	IN	_	32	case	_	_
32	apoptosis	apoptosis	NN	NN	_	26	nmod	_	_
33	and	and	CC	CC	_	26	cc	_	_
34	promote	promote	VB	VB	_	26	conj	_	_
35	limited	limited	JJ	JJ	_	36	amod	_	_
36	proliferation	proliferation	NN	NN	_	34	dobj	_	_
37	.	.	.	.	_	17	punct	_	_

1	SLP-76	slp-76	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Vav	vav	NN	NN	_	1	conj	_	_
4	function	function	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	separate	separate	JJ	JJ	_	4	nmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	overlapping	overlap	VBG	VBG	_	4	conj	_	_
10	pathways	pathway	NNS	NNS	_	9	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	augment	augment	VB	VB	_	9	advcl	_	_
13	interleukin-2	interleukin-2	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	SLP-76	slp-76	NN	NN	_	12	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	Vav	vav	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	two	two	CD	CD	_	9	nummod	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	9	amod	_	_
7	cell	cell	NN	NN	_	9	compound	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	molecules	molecule	NNS	NNS	_	1	appos	_	_
10	,	,	,	,	_	12	punct	_	_
11	are	be	VBP	VBP	_	12	cop	_	_
12	critical	critical	JJ	JJ	_	0	root	_	_
13	for	for	IN	IN	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	development	development	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	activation	activation	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	Following	follow	VBG	VBG	_	6	case	_	_
2	T	t	NN	NN	_	6	compound	_	_
3	cell	cell	NN	NN	_	6	compound	_	_
4	antigen	antigen	NN	NN	_	6	compound	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	stimulation	stimulation	NN	NN	_	12	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	SLP-76	slp-76	NN	NN	_	12	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Vav	vav	NN	NN	_	8	conj	_	_
11	both	both	DT	DT	_	12	advmod	_	_
12	undergo	undergo	VBP	VBP	_	0	root	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	associate	associate	VBP	VBP	_	12	conj	_	_
17	with	with	IN	IN	_	19	case	_	_
18	each	each	DT	DT	_	19	det	_	_
19	other	other	JJ	JJ	_	16	nmod	_	_
20	via	via	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	SH2	sh2	NN	NN	_	23	compound	_	_
23	domain	domain	NN	NN	_	16	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	Vav	vav	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	23	cc	_	_
27	phosphorylated	phosphorylate	VBN	VBN	_	28	amod	_	_
28	tyrosines	tyrosine	NNS	NNS	_	23	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	SLP-76	slp-76	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	12	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	SLP-76	slp-76	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Vav	vav	NN	NN	_	3	conj	_	_
6	have	have	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	synergistic	synergistic	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	6	dobj	_	_
10	on	on	IN	IN	_	17	case	_	_
11	interleukin	interleukin	NN	NN	_	17	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IL	il	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	-2	-2	CD	CD	_	17	nummod	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	9	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	6	nmod	_	_
21	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	two	two	CD	CD	_	9	nummod	_	_
9	tyrosines	tyrosine	NNS	NNS	_	18	nsubjpass	_	_
10	,	,	,	,	_	11	punct	_	_
11	Tyr-113	tyr-113	NN	NN	_	9	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Tyr-128	tyr-128	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	of	of	IN	IN	_	16	case	_	_
16	SLP-76	slp-76	NN	NN	_	9	nmod	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	required	require	VBN	VBN	_	6	ccomp	_	_
19	for	for	IN	IN	_	21	case	_	_
20	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
21	binding	binding	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	Vav	vav	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	21	punct	_	_
25	both	both	CC	CC	_	21	dep	_	_
26	in	in	FW	FW	_	27	compound	_	_
27	vitro	vitro	FW	FW	_	25	dep	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	in	in	IN	IN	_	31	case	_	_
30	intact	intact	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	25	conj	_	_
32	.	.	.	.	_	6	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	find	find	VBP	VBP	_	0	root	_	_
5	also	also	RB	RB	_	4	advmod	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	interaction	interaction	NN	NN	_	15	nsubjpass	_	_
9	between	between	IN	IN	_	10	case	_	_
10	SLP-76	slp-76	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Vav	vav	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	required	require	VBN	VBN	_	4	ccomp	_	_
16	for	for	IN	IN	_	18	case	_	_
17	their	they	PRP$	PRP$	_	18	nmod:poss	_	_
18	cooperation	cooperation	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	20	mark	_	_
20	augmenting	augment	VBG	VBG	_	18	acl	_	_
21	IL-2	il-2	NN	NN	_	23	compound	_	_
22	promoter	promoter	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	20	dobj	_	_
24	,	,	,	,	_	15	punct	_	_
25	as	as	IN	IN	_	29	mark	_	_
26	the	the	DT	DT	_	28	det	_	_
27	two	two	CD	CD	_	28	nummod	_	_
28	molecules	molecule	NNS	NNS	_	29	nsubj	_	_
29	appear	appear	VBP	VBP	_	15	advcl	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	function	function	VB	VB	_	29	xcomp	_	_
32	in	in	IN	IN	_	35	case	_	_
33	different	different	JJ	JJ	_	35	amod	_	_
34	signaling	signaling	NN	NN	_	35	compound	_	_
35	pathways	pathway	NNS	NNS	_	31	nmod	_	_
36	upstream	upstream	JJ	JJ	_	35	amod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	IL-2	il-2	NN	NN	_	40	compound	_	_
39	gene	gene	NN	NN	_	40	compound	_	_
40	expression	expression	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	Overexpression	overexpression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	SLP-76	slp-76	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	Jurkat	jurkat	NN	NN	_	9	compound	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	1	nmod	_	_
10	potentiates	potentiate	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activities	activity	NNS	NNS	_	10	dobj	_	_
13	of	of	IN	IN	_	20	case	_	_
14	both	both	CC	CC	_	20	cc:preconj	_	_
15	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
16	factor	factor	NN	NN	_	20	compound	_	_
17	of	of	IN	IN	_	20	amod	_	_
18	activated	activate	VBN	VBN	_	20	amod	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	12	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	AP-1	ap-1	NN	NN	_	24	compound	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factors	factor	NNS	NNS	_	20	conj	_	_
25	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	overexpression	overexpression	NN	NN	_	7	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	Vav	vav	NN	NN	_	4	nmod	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	16	case	_	_
9	enhanced	enhance	VBN	VBN	_	16	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
11	factor	factor	NN	NN	_	16	compound	_	_
12	of	of	IN	IN	_	16	amod	_	_
13	activated	activate	VBN	VBN	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cells	cell	NNS	NNS	_	16	compound	_	_
16	activity	activity	NN	NN	_	7	nmod	_	_
17	without	without	IN	IN	_	18	mark	_	_
18	affecting	affect	VBG	VBG	_	7	advcl	_	_
19	AP-1	ap-1	NN	NN	_	18	dobj	_	_
20	.	.	.	.	_	7	punct	_	_

1	Additionally	additionally	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	overexpression	overexpression	NN	NN	_	11	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Vav	vav	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	5	cc	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	SLP-76	slp-76	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	11	punct	_	_
11	augments	augment	VBZ	VBZ	_	0	root	_	_
12	CD28-induced	cd28-induced	JJ	JJ	_	15	amod	_	_
13	IL-2	il-2	NN	NN	_	15	compound	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	3	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	synergy	synergy	NN	NN	_	16	nsubj	_	_
7	between	between	IN	IN	_	8	case	_	_
8	SLP-76	slp-76	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	Vav	vav	NN	NN	_	8	conj	_	_
11	in	in	IN	IN	_	12	mark	_	_
12	regulating	regulate	VBG	VBG	_	6	acl	_	_
13	IL-2	il-2	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	dobj	_	_
16	reflects	reflect	VBZ	VBZ	_	4	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cooperation	cooperation	NN	NN	_	16	dobj	_	_
19	between	between	IN	IN	_	22	case	_	_
20	different	different	JJ	JJ	_	22	amod	_	_
21	signaling	signaling	NN	NN	_	22	compound	_	_
22	pathways	pathway	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	8	amod	_	_
2	T-cell	t-cell	NN	NN	_	8	compound	_	_
3	leukemia	leukemia	NN	NN	_	8	compound	_	_
4	virus	virus	NN	NN	_	8	compound	_	_
5	type	type	NN	NN	_	8	compound	_	_
6	1	1	CD	CD	_	8	nummod	_	_
7	Tax	tax	NN	NN	_	8	compound	_	_
8	protein	protein	NN	NN	_	9	nsubj	_	_
9	induces	induce	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	STAT1	stat1	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	STAT5	stat5	NN	NN	_	13	conj	_	_
16	genes	gene	NNS	NNS	_	13	dep	_	_
17	in	in	IN	IN	_	18	case	_	_
18	T-cells	t-cell	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	10	compound	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-1	htlv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	Tax	tax	NN	NN	_	11	nsubj	_	_
11	transforms	transform	VBZ	VBZ	_	0	root	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	T-cells	t-cell	NNS	NNS	_	11	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	presence	presence	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	interleukin	interleukin	NN	NN	_	16	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IL	il	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	-2	-2	CD	CD	_	18	nummod	_	_
23	in	in	FW	FW	_	24	compound	_	_
24	vitro	vitro	FW	FW	_	18	advmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	STAT	stat	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	family	family	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factors	factor	NNS	NNS	_	4	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	play	play	VBP	VBP	_	7	acl:relcl	_	_
10	a	a	DT	DT	_	12	det	_	_
11	pivotal	pivotal	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	cytokine-induced	cytokine-induced	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	type	type	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	cells	cell	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	involvement	involvement	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	STATs	stats	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	transformation	transformation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	T-cells	t-cell	NNS	NNS	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	HTLV-1	htlv-1	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	HTLV-1-transformed	htlv-1-transformed	JJ	JJ	_	3	amod	_	_
2	T-cell	t-cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	4	nsubj	_	_
4	expressed	express	VBD	VBD	_	0	root	_	_
5	higher	higher	JJR	JJR	_	6	amod	_	_
6	amounts	amount	NNS	NNS	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT1	stat1	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	STAT3	stat3	NN	NN	_	8	conj	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	STAT5	stat5	NN	NN	_	8	conj	_	_
13	RNA	rna	NN	NN	_	8	dep	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	proteins	protein	NNS	NNS	_	8	conj	_	_
16	than	than	IN	IN	_	19	case	_	_
17	virus-negative	virus-negative	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	6	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT1	stat1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	STAT5	stat5	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	T-cell	t-cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	4	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	induced	induce	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	15	case	_	_
15	Tax	tax	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	13	punct	_	_

1	IL-2	il-2	NN	NN	_	2	nsubj	_	_
2	induced	induce	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	6	det	_	_
4	DNA	dna	NN	NN	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	2	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT3	stat3	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	STAT5	stat5	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	HTLV-1-transformed	htlv-1-transformed	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	line	line	NN	NN	_	8	nmod	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	then	then	RB	RB	_	18	advmod	_	_
18	stimulated	stimulate	VBD	VBD	_	2	conj	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	proliferation	proliferation	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IL-2	il-2	NN	NN	_	5	nsubj	_	_
5	did	do	VBD	VBD	_	0	root	_	_
6	neither	neither	DT	DT	_	5	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	line	line	NN	NN	_	5	nmod	_	_
11	lacking	lack	VBG	VBG	_	10	acl	_	_
12	STAT3	stat3	NN	NN	_	11	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	STAT5	stat5	NN	NN	_	12	conj	_	_
15	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT1	stat1	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	STAT3	stat3	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	STAT5	stat5	NN	NN	_	4	conj	_	_
9	mRNAs	mrna	NNS	NNS	_	4	dep	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	induced	induce	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	T-cell	t-cell	NN	NN	_	16	compound	_	_
16	mitogen	mitogen	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	23	case	_	_
18	normal	normal	JJ	JJ	_	23	amod	_	_
19	human	human	JJ	JJ	_	23	amod	_	_
20	peripheral	peripheral	JJ	JJ	_	23	amod	_	_
21	blood	blood	NN	NN	_	23	compound	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	induction	induction	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STAT1	stat1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	STAT5	stat5	NN	NN	_	8	conj	_	_
11	by	by	IN	IN	_	12	case	_	_
12	Tax	tax	NN	NN	_	6	nmod	_	_
13	enhances	enhance	VBZ	VBZ	_	3	ccomp	_	_
14	cytokine-induced	cytokine-induced	JJ	JJ	_	15	amod	_	_
15	functions	function	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	virus-infected	virus-infected	JJ	JJ	_	18	amod	_	_
18	T-cells	t-cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	13	punct	_	_
20	hence	hence	RB	RB	_	24	advmod	_	_
21	the	the	DT	DT	_	22	det	_	_
22	induction	induction	NN	NN	_	24	nsubj	_	_
23	may	may	MD	MD	_	24	aux	_	_
24	play	play	VB	VB	_	13	parataxis	_	_
25	a	a	DT	DT	_	26	det	_	_
26	role	role	NN	NN	_	24	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	IL-2-dependent	il-2-dependent	JJ	JJ	_	30	amod	_	_
29	transformation	transformation	NN	NN	_	30	compound	_	_
30	steps	step	NNS	NNS	_	24	nmod	_	_
31	of	of	IN	IN	_	32	case	_	_
32	T-cells	t-cell	NNS	NNS	_	30	nmod	_	_
33	by	by	IN	IN	_	34	case	_	_
34	HTLV-1	htlv-1	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	Targeted	target	VBN	VBN	_	2	amod	_	_
2	remodeling	remodeling	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	8	case	_	_
4	human	human	JJ	JJ	_	8	amod	_	_
5	beta-globin	beta-globin	NN	NN	_	8	compound	_	_
6	promoter	promoter	NN	NN	_	8	compound	_	_
7	chromatin	chromatin	NN	NN	_	8	compound	_	_
8	structure	structure	NN	NN	_	2	nmod	_	_
9	produces	produce	VBZ	VBZ	_	0	root	_	_
10	increased	increase	VBN	VBN	_	11	amod	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	decreased	decrease	VBN	VBN	_	14	amod	_	_
14	silencing	silencing	NN	NN	_	11	conj	_	_
15	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chromatin	chromatin	NN	NN	_	3	compound	_	_
3	structure	structure	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	beta-globin	beta-globin	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	locus	locus	NN	NN	_	3	nmod	_	_
10	assumes	assume	VBZ	VBZ	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	transcriptionally-active	transcriptionally-active	JJ	JJ	_	13	amod	_	_
13	conformation	conformation	NN	NN	_	10	dobj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	10	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	feature	feature	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	this	this	DT	DT	_	6	det	_	_
5	chromatin	chromatin	NN	NN	_	6	compound	_	_
6	reorganization	reorganization	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	cop	_	_
8	the	the	DT	DT	_	9	det	_	_
9	formation	formation	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	14	case	_	_
11	DNase	dnase	NN	NN	_	14	compound	_	_
12	1	1	CD	CD	_	14	nummod	_	_
13	hypersensitive	hypersensitive	JJ	JJ	_	14	amod	_	_
14	sites	site	NNS	NNS	_	9	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	regions	region	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	active	active	JJ	JJ	_	22	amod	_	_
20	globin	globin	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	promoters	promoter	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	reorganization	reorganization	NN	NN	_	3	nsubj	_	_
3	requires	require	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	8	det	_	_
5	globin	globin	NN	NN	_	8	compound	_	_
6	locus	locus	NN	NN	_	8	compound	_	_
7	control	control	NN	NN	_	8	compound	_	_
8	region	region	NN	NN	_	3	dobj	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	3	conj	_	_
12	with	with	IN	IN	_	14	case	_	_
13	normal	normal	JJ	JJ	_	14	amod	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	beta-like	beta-like	JJ	JJ	_	19	amod	_	_
18	globin	globin	NN	NN	_	19	compound	_	_
19	genes	gene	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	23	advcl	_	_
3	whether	whether	IN	IN	_	6	mark	_	_
4	it	it	PRP	PRP	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	possible	possible	JJ	JJ	_	2	ccomp	_	_
7	to	to	TO	TO	_	9	mark	_	_
8	artificially	artificially	RB	RB	_	9	advmod	_	_
9	enhance	enhance	VB	VB	_	6	xcomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	opening	opening	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	chromatin	chromatin	NN	NN	_	15	compound	_	_
15	structure	structure	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	20	case	_	_
17	a	a	DT	DT	_	20	det	_	_
18	minimal	minimal	JJ	JJ	_	20	amod	_	_
19	beta-globin	beta-globin	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	23	punct	_	_
22	we	we	PRP	PRP	_	23	nsubj	_	_
23	placed	place	VBD	VBD	_	0	root	_	_
24	a	a	DT	DT	_	28	det	_	_
25	101bp	101bp	JJ	JJ	_	28	amod	_	_
26	,	,	,	,	_	28	punct	_	_
27	erythroid-specific	erythroid-specific	JJ	JJ	_	28	amod	_	_
28	DNase	dnase	NN	NN	_	23	dobj	_	_
29	1	1	CD	CD	_	28	nummod	_	_
30	hypersensitive	hypersensitive	JJ	JJ	_	32	amod	_	_
31	site-forming	site-forming	JJ	JJ	_	32	amod	_	_
32	element	element	NN	NN	_	28	dep	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	HSFE	hsfe	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	immediately	immediately	RB	RB	_	23	advmod	_	_
37	upstream	upstream	JJ	JJ	_	23	advmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	beta-globin	beta-globin	NN	NN	_	41	compound	_	_
41	promoter	promoter	NN	NN	_	37	nmod	_	_
42	and	and	CC	CC	_	41	cc	_	_
43	gene	gene	NN	NN	_	41	conj	_	_
44	.	.	.	.	_	23	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	3	nsubj	_	_
3	includes	include	VBZ	VBZ	_	0	root	_	_
4	binding	bind	VBG	VBG	_	5	amod	_	_
5	sites	site	NNS	NNS	_	3	dobj	_	_
6	for	for	IN	IN	_	7	case	_	_
7	NF-E2	nf-e2	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	AP-1	ap-1	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	7	punct	_	_
11	GATA-1	gata-1	NN	NN	_	7	conj	_	_
12	and	and	CC	CC	_	7	cc	_	_
13	Sp-1	sp-1	NN	NN	_	7	conj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Constructs	construct	NNS	NNS	_	4	nsubjpass	_	_
2	were	be	VBD	VBD	_	4	auxpass	_	_
3	stably	stably	RB	RB	_	4	advmod	_	_
4	transfected	transfect	VBN	VBN	_	0	root	_	_
5	into	into	IN	IN	_	8	case	_	_
6	murine	murine	JJ	JJ	_	8	amod	_	_
7	erythroleukemia	erythroleukemia	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	promoter	promoter	NN	NN	_	12	compound	_	_
11	chromatin	chromatin	NN	NN	_	12	compound	_	_
12	structure	structure	NN	NN	_	17	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	12	conj	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	analyzed	analyze	VBN	VBN	_	4	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	HSFE	hsfe	NN	NN	_	3	nsubj	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	an	a	DT	DT	_	5	det	_	_
5	area	area	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	enhanced	enhance	VBN	VBN	_	10	amod	_	_
8	DNase	dnase	NN	NN	_	10	compound	_	_
9	1	1	CD	CD	_	10	nummod	_	_
10	hypersensitivity	hypersensitivity	NN	NN	_	5	nmod	_	_
11	extending	extend	VBG	VBG	_	5	acl	_	_
12	from	from	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
15	start	start	NN	NN	_	16	compound	_	_
16	site	site	NN	NN	_	11	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	-300bp	-300bp	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	artificial	artificial	JJ	JJ	_	22	amod	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	3	cc	_	_
24	significantly	significantly	RB	RB	_	25	advmod	_	_
25	increased	increase	VBD	VBD	_	3	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	proportion	proportion	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	beta-globin	beta-globin	NN	NN	_	30	compound	_	_
30	promoters	promoter	NNS	NNS	_	27	nmod	_	_
31	in	in	IN	IN	_	35	case	_	_
32	an	a	DT	DT	_	35	det	_	_
33	open	open	JJ	JJ	_	35	amod	_	_
34	chromatin	chromatin	NN	NN	_	35	compound	_	_
35	configuration	configuration	NN	NN	_	27	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	remodeling	remodeling	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	promoter	promoter	NN	NN	_	6	compound	_	_
5	chromatin	chromatin	NN	NN	_	6	compound	_	_
6	structure	structure	NN	NN	_	2	nmod	_	_
7	resulted	result	VBD	VBD	_	0	root	_	_
8	in	in	IN	IN	_	10	case	_	_
9	3-fold	3-fold	JJ	JJ	_	10	nummod	_	_
10	increases	increase	NNS	NNS	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	beta-globin	beta-globin	NN	NN	_	14	compound	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	transcription	transcription	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	induction	induction	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	7	punct	_	_
18	and	and	CC	CC	_	7	cc	_	_
19	inhibited	inhibit	VBD	VBD	_	7	conj	_	_
20	long-term	long-term	JJ	JJ	_	23	amod	_	_
21	beta-globin	beta-globin	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	silencing	silencing	NN	NN	_	19	dobj	_	_
24	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	a	a	DT	DT	_	9	det	_	_
6	relatively	relatively	RB	RB	_	7	advmod	_	_
7	small	small	JJ	JJ	_	9	amod	_	_
8	cis-acting	cis-acting	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	11	nsubj	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	able	able	JJ	JJ	_	3	ccomp	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	enhance	enhance	VB	VB	_	11	xcomp	_	_
14	remodeling	remodeling	NN	NN	_	13	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	promoter	promoter	NN	NN	_	18	compound	_	_
17	chromatin	chromatin	NN	NN	_	18	compound	_	_
18	structure	structure	NN	NN	_	14	nmod	_	_
19	resulting	result	VBG	VBG	_	13	xcomp	_	_
20	in	in	IN	IN	_	24	case	_	_
21	increased	increase	VBN	VBN	_	24	amod	_	_
22	beta-globin	beta-globin	NN	NN	_	24	compound	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Selection	selection	NN	NN	_	15	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	long-term	long-term	JJ	JJ	_	4	amod	_	_
4	persistence	persistence	NN	NN	_	1	conj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	reactive	reactive	JJ	JJ	_	8	amod	_	_
7	CTL	ctl	NN	NN	_	8	compound	_	_
8	clones	clone	NNS	NNS	_	1	nmod	_	_
9	during	during	IN	IN	_	13	case	_	_
10	an	a	DT	DT	_	13	det	_	_
11	EBV	ebv	NN	NN	_	13	compound	_	_
12	chronic	chronic	JJ	JJ	_	13	amod	_	_
13	response	response	NN	NN	_	8	nmod	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	determined	determine	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	17	case	_	_
17	avidity	avidity	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	CD8	cd8	NN	NN	_	21	compound	_	_
20	variable	variable	JJ	JJ	_	21	amod	_	_
21	contribution	contribution	NN	NN	_	17	appos	_	_
22	compensating	compensate	VBG	VBG	_	21	acl	_	_
23	for	for	IN	IN	_	24	case	_	_
24	differences	difference	NNS	NNS	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	TCR	tcr	NN	NN	_	27	compound	_	_
27	affinities	affinity	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	15	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	diversity	diversity	NN	NN	_	15	nsubjpass	_	_
8	of	of	IN	IN	_	10	case	_	_
9	TCR	tcr	NN	NN	_	10	compound	_	_
10	repertoire	repertoire	NN	NN	_	7	nmod	_	_
11	after	after	IN	IN	_	13	case	_	_
12	primary	primary	JJ	JJ	_	13	amod	_	_
13	immunization	immunization	NN	NN	_	7	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	conserved	conserve	VBN	VBN	_	4	ccomp	_	_
16	in	in	IN	IN	_	19	case	_	_
17	memory	memory	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	that	that	IN	IN	_	29	mark	_	_
22	a	a	DT	DT	_	24	det	_	_
23	progressive	progressive	JJ	JJ	_	24	amod	_	_
24	narrowing	narrowing	NN	NN	_	29	nsubj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	this	this	DT	DT	_	27	det	_	_
27	repertoire	repertoire	NN	NN	_	24	nmod	_	_
28	may	may	MD	MD	_	29	aux	_	_
29	take	take	VB	VB	_	15	conj	_	_
30	place	place	NN	NN	_	29	dep	_	_
31	during	during	IN	IN	_	33	case	_	_
32	recall	recall	NN	NN	_	33	compound	_	_
33	infections	infection	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	remains	remain	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	investigated	investigate	VBN	VBN	_	3	xcomp	_	_
7	which	which	WDT	WDT	_	8	det	_	_
8	parameters	parameter	NNS	NNS	_	9	nsubj	_	_
9	determine	determine	VBP	VBP	_	6	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	repertoire	repertoire	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	memory	memory	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	possibly	possibly	RB	RB	_	18	advmod	_	_
18	restrict	restrict	VB	VB	_	9	conj	_	_
19	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
20	diversity	diversity	NN	NN	_	18	dobj	_	_
21	after	after	IN	IN	_	24	case	_	_
22	subsequent	subsequent	JJ	JJ	_	24	amod	_	_
23	antigenic	antigenic	JJ	JJ	_	24	amod	_	_
24	challenges	challenge	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	7	advcl	_	_
3	this	this	DT	DT	_	4	det	_	_
4	question	question	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	took	take	VBD	VBD	_	0	root	_	_
8	advantage	advantage	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	panel	panel	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	CD8+	cd8+	JJ	JJ	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	clones	clone	NNS	NNS	_	11	nmod	_	_
17	from	from	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	joint	joint	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	a	a	DT	DT	_	24	det	_	_
22	rheumatoid	rheumatoid	JJ	JJ	_	24	amod	_	_
23	arthritis	arthritis	NN	NN	_	24	compound	_	_
24	patient	patient	NN	NN	_	19	nmod	_	_
25	and	and	CC	CC	_	7	cc	_	_
26	selected	select	VBD	VBD	_	7	conj	_	_
27	for	for	IN	IN	_	29	case	_	_
28	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
29	reactivity	reactivity	NN	NN	_	26	nmod	_	_
30	against	against	IN	IN	_	34	case	_	_
31	a	a	DT	DT	_	34	det	_	_
32	single	single	JJ	JJ	_	34	amod	_	_
33	MHC/peptide	mhc/peptide	NN	NN	_	34	compound	_	_
34	complex	complex	NN	NN	_	29	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	Characterization	characterization	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	both	both	DT	DT	_	5	det	_	_
4	TCR	tcr	NN	NN	_	5	compound	_	_
5	chains	chain	NNS	NNS	_	1	nmod	_	_
6	documented	document	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	great	great	JJ	JJ	_	9	amod	_	_
9	diversity	diversity	NN	NN	_	6	dobj	_	_
10	among	among	IN	IN	_	12	case	_	_
11	those	those	DT	DT	_	12	det	_	_
12	clones	clone	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	persistence	persistence	NN	NN	_	9	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	clonotypes	clonotype	NNS	NNS	_	15	nmod	_	_
18	over	over	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	2-yr	2-yr	JJ	JJ	_	21	amod	_	_
21	period	period	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Strikingly	strikingly	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	despite	despite	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	observed	observe	VBN	VBN	_	7	amod	_	_
6	repertoire	repertoire	NN	NN	_	7	compound	_	_
7	heterogeneity	heterogeneity	NN	NN	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	all	all	DT	DT	_	10	det	_	_
10	clones	clone	NNS	NNS	_	11	nsubj	_	_
11	displayed	display	VBD	VBD	_	0	root	_	_
12	a	a	DT	DT	_	14	det	_	_
13	narrow	narrow	JJ	JJ	_	14	amod	_	_
14	range	range	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	MHC/peptide	mhc/peptide	NN	NN	_	18	compound	_	_
17	density	density	NN	NN	_	18	compound	_	_
18	requirements	requirement	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	cytotoxicity	cytotoxicity	NN	NN	_	21	compound	_	_
21	assays	assay	NNS	NNS	_	11	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	ED50	ed50	NN	NN	_	21	dep	_	_
24	between	between	IN	IN	_	25	case	_	_
25	9	9	CD	CD	_	23	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	36	36	CD	CD	_	25	conj	_	_
28	nM	nm	NN	NN	_	25	dep	_	_
29	)	)	-RRB-	-RRB-	_	23	punct	_	_
30	.	.	.	.	_	11	punct	_	_

1	TCR	tcr	NN	NN	_	2	compound	_	_
2	affinities	affinity	NNS	NNS	_	6	nsubjpass	_	_
3	were	be	VBD	VBD	_	6	auxpass	_	_
4	then	then	RB	RB	_	6	advmod	_	_
5	indirectly	indirectly	RB	RB	_	6	advmod	_	_
6	estimated	estimate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	blocking	block	VBG	VBG	_	6	advcl	_	_
9	CD8	cd8	NN	NN	_	10	compound	_	_
10	interaction	interaction	NN	NN	_	8	dobj	_	_
11	with	with	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	anti-CD8	anti-cd8	JJ	JJ	_	14	amod	_	_
14	mAb	mab	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	wide	wide	JJ	JJ	_	5	amod	_	_
5	range	range	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	TCR	tcr	NN	NN	_	8	compound	_	_
8	affinities	affinity	NNS	NNS	_	5	nmod	_	_
9	among	among	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	clonotypes	clonotype	NNS	NNS	_	2	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	segregated	segregate	VBD	VBD	_	12	acl:relcl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	Vbeta	vbeta	NN	NN	_	17	compound	_	_
17	usage	usage	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	thus	thus	RB	RB	_	3	advmod	_	_
3	propose	propose	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	during	during	IN	IN	_	10	case	_	_
6	an	a	DT	DT	_	10	det	_	_
7	in	in	FW	FW	_	9	compound	_	_
8	vivo	vivo	FW	FW	_	9	dep	_	_
9	chronic	chronic	JJ	JJ	_	10	amod	_	_
10	response	response	NN	NN	_	21	nmod	_	_
11	,	,	,	,	_	21	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	narrow	narrow	JJ	JJ	_	14	amod	_	_
14	range	range	NN	NN	_	21	nsubj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	avidity	avidity	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	TCR-CD8	tcr-cd8	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	16	nmod	_	_
21	conditions	condition	VBZ	VBZ	_	3	ccomp	_	_
22	long-term	long-term	JJ	JJ	_	24	amod	_	_
23	clonotype	clonotype	NN	NN	_	24	compound	_	_
24	persistence	persistence	NN	NN	_	21	dobj	_	_
25	,	,	,	,	_	21	punct	_	_
26	and	and	CC	CC	_	21	cc	_	_
27	that	that	IN	IN	_	34	mark	_	_
28	the	the	DT	DT	_	29	det	_	_
29	level	level	NN	NN	_	34	nsubjpass	_	_
30	of	of	IN	IN	_	32	case	_	_
31	CD8	cd8	NN	NN	_	32	compound	_	_
32	contribution	contribution	NN	NN	_	29	nmod	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	adjusted	adjust	VBN	VBN	_	21	conj	_	_
35	to	to	TO	TO	_	36	mark	_	_
36	keep	keep	VB	VB	_	34	xcomp	_	_
37	clonotypes	clonotype	NNS	NNS	_	36	dobj	_	_
38	with	with	IN	IN	_	41	case	_	_
39	variable	variable	JJ	JJ	_	41	amod	_	_
40	TCR	tcr	NN	NN	_	41	compound	_	_
41	affinities	affinity	NNS	NNS	_	37	nmod	_	_
42	within	within	IN	IN	_	45	case	_	_
43	this	this	DT	DT	_	45	det	_	_
44	avidity	avidity	NN	NN	_	45	compound	_	_
45	window	window	NN	NN	_	36	nmod	_	_
46	.	.	.	.	_	3	punct	_	_

1	In	in	FW	FW	_	3	amod	_	_
2	vivo	vivo	FW	FW	_	1	dep	_	_
3	inhibition	inhibition	NN	NN	_	10	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T-lineage	t-lineage	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	3	nmod	_	_
10	leads	lead	VBZ	VBZ	_	0	root	_	_
11	to	to	TO	TO	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	dramatic	dramatic	JJ	JJ	_	14	amod	_	_
14	decrease	decrease	NN	NN	_	10	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	proliferation	proliferation	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	production	production	NN	NN	_	17	conj	_	_
21	and	and	CC	CC	_	14	cc	_	_
22	to	to	TO	TO	_	25	case	_	_
23	increased	increase	VBN	VBN	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	apoptosis	apoptosis	NN	NN	_	14	conj	_	_
26	in	in	IN	IN	_	27	case	_	_
27	response	response	NN	NN	_	25	nmod	_	_
28	to	to	TO	TO	_	30	case	_	_
29	mitogenic	mitogenic	JJ	JJ	_	30	amod	_	_
30	stimuli	stimulus	NNS	NNS	_	27	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	but	but	CC	CC	_	30	cc	_	_
33	not	not	RB	RB	_	36	neg	_	_
34	to	to	TO	TO	_	36	case	_	_
35	abnormal	abnormal	JJ	JJ	_	36	amod	_	_
36	thymopoiesis	thymopoiesis	NN	NN	_	30	conj	_	_
37	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	18	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	complexes	complex	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	4	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	activation	activation	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	18	punct	_	_
16	we	we	PRP	PRP	_	18	nsubj	_	_
17	have	have	VBP	VBP	_	18	aux	_	_
18	generated	generate	VBN	VBN	_	0	root	_	_
19	transgenic	transgenic	JJ	JJ	_	20	amod	_	_
20	mice	mouse	NNS	NNS	_	18	dobj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	which	which	WDT	WDT	_	29	nmod	_	_
23	RelA	rela	NN	NN	_	29	nsubjpass	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	c-Rel	c-rel	NN	NN	_	26	compound	_	_
26	complexes	complex	NNS	NNS	_	23	conj	_	_
27	were	be	VBD	VBD	_	29	auxpass	_	_
28	selectively	selectively	RB	RB	_	29	advmod	_	_
29	inhibited	inhibit	VBN	VBN	_	20	acl:relcl	_	_
30	in	in	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	T-lineage	t-lineage	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	29	nmod	_	_
34	by	by	IN	IN	_	36	case	_	_
35	specific	specific	JJ	JJ	_	36	amod	_	_
36	expression	expression	NN	NN	_	29	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	trans-dominant	trans-dominant	JJ	JJ	_	40	amod	_	_
40	form	form	NN	NN	_	36	nmod	_	_
41	of	of	IN	IN	_	45	case	_	_
42	I	i	NN	NN	_	45	compound	_	_
43	kappa	kappa	NN	NN	_	45	compound	_	_
44	B	b	NN	NN	_	45	compound	_	_
45	alpha	alpha	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	18	punct	_	_

1	Transgene	transgene	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	5	nsubj	_	_
3	did	do	VBD	VBD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	affect	affect	VB	VB	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	thymic	thymic	JJ	JJ	_	8	amod	_	_
8	development	development	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	5	punct	_	_
10	but	but	CC	CC	_	5	cc	_	_
11	led	lead	VBD	VBD	_	5	conj	_	_
12	to	to	TO	TO	_	14	case	_	_
13	lowered	lowered	JJ	JJ	_	14	amod	_	_
14	numbers	number	NNS	NNS	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	splenic	splenic	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	to	to	TO	TO	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	dramatic	dramatic	JJ	JJ	_	23	amod	_	_
23	decrease	decrease	NN	NN	_	14	conj	_	_
24	in	in	IN	IN	_	29	case	_	_
25	the	the	DT	DT	_	29	det	_	_
26	ex	ex	FW	FW	_	29	compound	_	_
27	vivo	vivo	FW	FW	_	29	compound	_	_
28	proliferative	proliferative	JJ	JJ	_	29	amod	_	_
29	response	response	NN	NN	_	23	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	splenic	splenic	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	lymphocytes	lymphocyte	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	5	punct	_	_

1	Analysis	analysis	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-2R	il-2r	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	conj	_	_
8	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	18	mark	_	_
10	the	the	DT	DT	_	11	det	_	_
11	perturbation	perturbation	NN	NN	_	18	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	proliferation	proliferation	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	11	nmod	_	_
16	was	be	VBD	VBD	_	18	cop	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	attributable	attributable	JJ	JJ	_	8	ccomp	_	_
19	to	to	TO	TO	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	abnormal	abnormal	JJ	JJ	_	22	amod	_	_
22	expression	expression	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	14	nmod	_	_
3	,	,	,	,	_	14	punct	_	_
4	expression	expression	NN	NN	_	14	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	IL-4	il-4	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	IL-10	il-10	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	IFN-gamma	ifn-gamma	NN	NN	_	6	conj	_	_
12	was	be	VBD	VBD	_	14	auxpass	_	_
13	strongly	strongly	RB	RB	_	14	advmod	_	_
14	inhibited	inhibit	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	transgenic	transgenic	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	proliferative	proliferative	JJ	JJ	_	3	amod	_	_
3	deficiency	deficiency	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	associated	associate	VBN	VBN	_	0	root	_	_
11	with	with	IN	IN	_	14	case	_	_
12	an	a	DT	DT	_	14	det	_	_
13	increased	increase	VBN	VBN	_	14	amod	_	_
14	apoptosis	apoptosis	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	point	point	VBP	VBP	_	0	root	_	_
4	out	out	RP	RP	_	3	dep	_	_
5	the	the	DT	DT	_	6	det	_	_
6	involvement	involvement	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	11	compound	_	_
9	B/Rel	b/rel	NN	NN	_	11	compound	_	_
10	family	family	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	6	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	growth	growth	NN	NN	_	15	compound	_	_
14	signaling	signaling	NN	NN	_	15	compound	_	_
15	pathways	pathway	NNS	NNS	_	6	nmod	_	_
16	by	by	IN	IN	_	19	case	_	_
17	either	either	CC	CC	_	19	dep	_	_
18	regulating	regulate	VBG	VBG	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	6	nmod	_	_
20	involved	involve	VBN	VBN	_	19	acl	_	_
21	in	in	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IL-2	il-2	NN	NN	_	24	compound	_	_
24	signaling	signaling	NN	NN	_	20	nmod	_	_
25	or	or	CC	CC	_	19	cc	_	_
26	by	by	IN	IN	_	28	mark	_	_
27	functionally	functionally	RB	RB	_	28	advmod	_	_
28	interfering	interfere	VBG	VBG	_	19	conj	_	_
29	with	with	IN	IN	_	33	case	_	_
30	the	the	DT	DT	_	33	det	_	_
31	cell	cell	NN	NN	_	33	compound	_	_
32	cycle	cycle	NN	NN	_	33	compound	_	_
33	progression	progression	NN	NN	_	28	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	Modulation	modulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	CD28	cd28	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	1	nmod	_	_
5	:	:	:	:	_	1	punct	_	_
6	distinct	distinct	JJ	JJ	_	8	amod	_	_
7	regulatory	regulatory	JJ	JJ	_	8	amod	_	_
8	pathways	pathway	NNS	NNS	_	1	dep	_	_
9	during	during	IN	IN	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	replicative	replicative	JJ	JJ	_	13	amod	_	_
13	senescence	senescence	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	costimulatory	costimulatory	JJ	JJ	_	3	amod	_	_
3	molecule	molecule	NN	NN	_	5	nsubj	_	_
4	CD28	cd28	NN	NN	_	3	dep	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	restricted	restricted	JJ	JJ	_	9	amod	_	_
8	tissue	tissue	NN	NN	_	9	compound	_	_
9	distribution	distribution	NN	NN	_	5	dobj	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	expressed	express	VBN	VBN	_	5	conj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	some	some	DT	DT	_	19	det	_	_
18	plasmacytoma	plasmacytoma	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	conj	_	_
20	.	.	.	.	_	5	punct	_	_

1	Although	although	IN	IN	_	5	mark	_	_
2	CD28	cd28	NN	NN	_	5	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	5	auxpass	_	_
4	constitutively	constitutively	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	11	advcl	_	_
6	,	,	,	,	_	11	punct	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	expression	expression	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	transiently	transiently	RB	RB	_	11	advmod	_	_
11	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
12	following	follow	VBG	VBG	_	15	case	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	activation	activation	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	declines	decline	VBZ	VBZ	_	11	conj	_	_
18	progressively	progressively	RB	RB	_	17	advmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	vitro	vitro	FW	FW	_	20	dep	_	_
22	senescence	senescence	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	17	advmod	_	_
3	,	,	,	,	_	17	punct	_	_
4	CD8+	cd8+	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	17	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	,	,	,	,	_	6	punct	_	_
9	less	less	RBR	RBR	_	10	advmod	_	_
10	frequently	frequently	RB	RB	_	6	advmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	CD4+	cd4+	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	6	conj	_	_
15	may	may	MD	MD	_	17	aux	_	_
16	completely	completely	RB	RB	_	17	advmod	_	_
17	lose	lose	VB	VB	_	0	root	_	_
18	CD28	cd28	NN	NN	_	20	compound	_	_
19	surface	surface	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	17	dobj	_	_
21	during	during	IN	IN	_	23	case	_	_
22	chronic	chronic	JJ	JJ	_	23	amod	_	_
23	infections	infection	NNS	NNS	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	with	with	IN	IN	_	26	case	_	_
26	aging	aging	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	correlates	correlate	VBZ	VBZ	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	changes	change	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	8	case	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	protein-binding	protein-binding	JJ	JJ	_	8	amod	_	_
8	activities	activity	NNS	NNS	_	4	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	motifs	motif	NNS	NNS	_	4	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	site	site	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	appos	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	beta	beta	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	within	within	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	CD28	cd28	NN	NN	_	22	compound	_	_
21	minimal	minimal	JJ	JJ	_	22	amod	_	_
22	promoter	promoter	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	alpha-	alpha-	NN	NN	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	beta-bound	beta-bound	JJ	JJ	_	2	conj	_	_
5	complexes	complex	NNS	NNS	_	2	dep	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	found	find	VBN	VBN	_	0	root	_	_
8	only	only	RB	RB	_	7	advcl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	lymphoid	lymphoid	JJ	JJ	_	11	amod	_	_
11	tissues	tissue	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	11	punct	_	_
13	in	in	IN	IN	_	16	case	_	_
14	CD28+	cd28+	JJ	JJ	_	16	amod	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	11	conj	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	in	in	IN	IN	_	23	case	_	_
20	some	some	DT	DT	_	23	det	_	_
21	transformed	transform	VBN	VBN	_	23	amod	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	11	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	complexes	complex	NNS	NNS	_	5	nsubjpass	_	_
3	are	be	VBP	VBP	_	5	auxpass	_	_
4	coordinately	coordinately	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	0	root	_	_
6	except	except	IN	IN	_	9	case	_	_
7	during	during	IN	IN	_	9	case	_	_
8	replicative	replicative	JJ	JJ	_	9	amod	_	_
9	senescence	senescence	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	which	which	WDT	WDT	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	characterized	characterize	VBN	VBN	_	9	acl:relcl	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	down-modulation	down-modulation	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	site	site	NN	NN	_	19	compound	_	_
19	beta-	beta-	NN	NN	_	16	nmod	_	_
20	but	but	CC	CC	_	19	cc	_	_
21	not	not	RB	RB	_	24	neg	_	_
22	site	site	NN	NN	_	24	compound	_	_
23	alpha-binding	alpha-binding	JJ	JJ	_	24	amod	_	_
24	activities	activity	NNS	NNS	_	19	conj	_	_
25	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	parallel	parallel	JJ	JJ	_	10	amod	_	_
10	decline	decline	NN	NN	_	7	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	both	both	CC	CC	_	14	cc:preconj	_	_
13	site	site	NN	NN	_	14	compound	_	_
14	alpha-	alpha-	NN	NN	_	7	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	beta-binding	beta-binding	JJ	JJ	_	17	amod	_	_
17	activities	activity	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	CD4+	cd4+	JJ	JJ	_	6	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	CD8+	cd8+	JJ	JJ	_	5	amod	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	1	conj	_	_
6	differ	differ	VBP	VBP	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	their	they	PRP$	PRP$	_	10	nmod:poss	_	_
9	beta-binding	beta-binding	JJ	JJ	_	10	amod	_	_
10	profiles	profile	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	may	may	MD	MD	_	14	aux	_	_
14	explain	explain	VB	VB	_	6	ccomp	_	_
15	the	the	DT	DT	_	18	det	_	_
16	more	more	RBR	RBR	_	17	advmod	_	_
17	pronounced	pronounced	JJ	JJ	_	18	amod	_	_
18	down-regulation	down-regulation	NN	NN	_	14	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	CD28	cd28	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	25	case	_	_
22	senescent	senescent	JJ	JJ	_	25	amod	_	_
23	CD8+	cd8+	JJ	JJ	_	25	amod	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	18	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	In	in	FW	FW	_	2	compound	_	_
2	vivo	vivo	FW	FW	_	10	advmod	_	_
3	expanded	expand	VBN	VBN	_	4	amod	_	_
4	CD4+CD28null	cd4+cd28null	JJ	JJ	_	10	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	CD8+CD28null	cd8+cd28null	JJ	JJ	_	4	conj	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	dep	_	_
9	uniformly	uniformly	RB	RB	_	10	advmod	_	_
10	lack	lack	VBP	VBP	_	0	root	_	_
11	alpha-	alpha-	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	beta-bound	beta-bound	JJ	JJ	_	14	amod	_	_
14	complexes	complex	NNS	NNS	_	11	conj	_	_
15	,	,	,	,	_	11	punct	_	_
16	resembling	resemble	VBG	VBG	_	11	dep	_	_
17	the	the	DT	DT	_	18	det	_	_
18	pattern	pattern	NN	NN	_	16	xcomp	_	_
19	seen	see	VBN	VBN	_	18	acl	_	_
20	in	in	IN	IN	_	23	case	_	_
21	chronically	chronically	RB	RB	_	23	advmod	_	_
22	activated	activate	VBN	VBN	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	not	not	RB	RB	_	28	neg	_	_
26	of	of	IN	IN	_	28	case	_	_
27	senescent	senescent	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	23	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	CD28	cd28	NN	NN	_	2	compound	_	_
2	costimulation	costimulation	NN	NN	_	3	nsubj	_	_
3	augments	augment	VBZ	VBZ	_	0	root	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	secretion	secretion	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	11	case	_	_
7	activated	activate	VBN	VBN	_	11	amod	_	_
8	lamina	lamina	NN	NN	_	11	compound	_	_
9	propria	propria	NN	NN	_	11	compound	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	5	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	increasing	increase	VBG	VBG	_	3	advcl	_	_
14	mRNA	mrna	NN	NN	_	15	compound	_	_
15	stability	stability	NN	NN	_	13	dobj	_	_
16	without	without	IN	IN	_	17	mark	_	_
17	enhancing	enhance	VBG	VBG	_	13	advcl	_	_
18	IL-2	il-2	NN	NN	_	20	compound	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	transactivation	transactivation	NN	NN	_	17	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pathways	pathway	NNS	NNS	_	15	nsubj	_	_
3	leading	lead	VBG	VBG	_	2	acl	_	_
4	to	to	TO	TO	_	5	case	_	_
5	activation	activation	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	13	case	_	_
7	lamina	lamina	NN	NN	_	13	compound	_	_
8	propria	propria	NN	NN	_	13	compound	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	LP	lp	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	5	nmod	_	_
14	are	be	VBP	VBP	_	15	cop	_	_
15	different	different	JJ	JJ	_	0	root	_	_
16	from	from	IN	IN	_	19	case	_	_
17	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	LP	lp	NN	NN	_	3	compound	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	4	nsubj	_	_
4	exhibit	exhibit	VBP	VBP	_	0	root	_	_
5	enhanced	enhance	VBN	VBN	_	7	amod	_	_
6	IL-2	il-2	NN	NN	_	7	compound	_	_
7	secretion	secretion	NN	NN	_	4	dobj	_	_
8	when	when	WRB	WRB	_	9	advmod	_	_
9	activated	activate	VBN	VBN	_	4	advcl	_	_
10	through	through	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CD2	cd2	NN	NN	_	13	compound	_	_
13	pathway	pathway	NN	NN	_	9	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Coligation	coligation	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD28	cd28	NN	NN	_	1	nmod	_	_
4	leads	lead	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	synergistic	synergistic	JJ	JJ	_	7	amod	_	_
7	enhancement	enhancement	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	4	punct	_	_

1	Previous	previous	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	characterized	characterize	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CD28	cd28	NN	NN	_	7	compound	_	_
7	augmentation	augmentation	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	TCR-mediated	tcr-mediated	JJ	JJ	_	10	amod	_	_
10	signaling	signaling	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	15	case	_	_
12	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
13	blood	blood	NN	NN	_	15	compound	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	through	through	IN	IN	_	18	case	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	7	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	an	a	DT	DT	_	22	det	_	_
21	IL-2	il-2	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	CD28	cd28	NN	NN	_	25	compound	_	_
24	response	response	NN	NN	_	25	compound	_	_
25	element	element	NN	NN	_	22	dep	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	CD28RE	cd28re	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	,	,	,	,	_	18	punct	_	_
30	along	along	IN	IN	_	34	case	_	_
31	with	with	IN	IN	_	34	case	_	_
32	enhanced	enhance	VBN	VBN	_	34	amod	_	_
33	mRNA	mrna	NN	NN	_	34	compound	_	_
34	stability	stability	NN	NN	_	18	nmod	_	_
35	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	characterized	characterize	VBD	VBD	_	0	root	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	events	event	NNS	NNS	_	3	dobj	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	CD28	cd28	NN	NN	_	9	compound	_	_
9	costimulation	costimulation	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	LP	lp	NN	NN	_	16	compound	_	_
15	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	LPMC	lpmc	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	3	punct	_	_

1	LPMC	lpmc	NN	NN	_	2	nsubj	_	_
2	exhibited	exhibit	VBD	VBD	_	0	root	_	_
3	increased	increase	VBN	VBN	_	5	amod	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	CD28	cd28	NN	NN	_	10	compound	_	_
10	costimulation	costimulation	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	compared	compare	VBN	VBN	_	2	advcl	_	_
13	with	with	IN	IN	_	14	case	_	_
14	cells	cell	NNS	NNS	_	12	nmod	_	_
15	activated	activate	VBN	VBN	_	14	acl	_	_
16	through	through	IN	IN	_	17	case	_	_
17	CD2	cd2	NN	NN	_	15	nmod	_	_
18	alone	alone	RB	RB	_	17	amod	_	_
19	.	.	.	.	_	2	punct	_	_

1	IL-2	il-2	NN	NN	_	2	compound	_	_
2	secretion	secretion	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	paralleled	parallel	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	7	case	_	_
6	increased	increase	VBN	VBN	_	7	amod	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IL-2	il-2	NN	NN	_	10	compound	_	_
10	mRNA	mrna	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	resulting	result	VBG	VBG	_	10	acl	_	_
13	from	from	IN	IN	_	17	case	_	_
14	enhanced	enhance	VBN	VBN	_	17	amod	_	_
15	IL-2	il-2	NN	NN	_	17	compound	_	_
16	mRNA	mrna	NN	NN	_	17	compound	_	_
17	stability	stability	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	33	nmod	_	_
3	to	to	TO	TO	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	7	case	_	_
7	PBMC	pbmc	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	33	punct	_	_
9	EMSA	emsa	NN	NN	_	10	nsubj	_	_
10	revealed	reveal	VBD	VBD	_	33	ccomp	_	_
11	that	that	IN	IN	_	19	mark	_	_
12	CD28	cd28	NN	NN	_	13	compound	_	_
13	coligation	coligation	NN	NN	_	19	nsubj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	CD2-activated	cd2-activated	JJ	JJ	_	16	amod	_	_
16	LPMC	lpmc	NN	NN	_	13	nmod	_	_
17	does	do	VBZ	VBZ	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	result	result	VB	VB	_	10	ccomp	_	_
20	in	in	IN	IN	_	22	case	_	_
21	increased	increase	VBN	VBN	_	22	amod	_	_
22	binding	binding	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	trans-factors	trans-factor	NNS	NNS	_	22	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	CD28RE	cd28re	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	33	punct	_	_
29	nor	nor	CC	CC	_	33	cc	_	_
30	did	do	VBD	VBD	_	33	conj	_	_
31	Western	western	NN	NN	_	32	compound	_	_
32	blots	blot	NNS	NNS	_	33	nsubj	_	_
33	detect	detect	VB	VB	_	0	root	_	_
34	changes	change	NNS	NNS	_	33	dobj	_	_
35	in	in	IN	IN	_	39	case	_	_
36	I-kappaBalpha	i-kappabalpha	NN	NN	_	39	compound	_	_
37	or	or	CC	CC	_	36	cc	_	_
38	I-kappaBbeta	i-kappabbeta	NN	NN	_	36	conj	_	_
39	levels	level	NNS	NNS	_	34	nmod	_	_
40	following	follow	VBG	VBG	_	42	case	_	_
41	CD28	cd28	NN	NN	_	42	compound	_	_
42	coligation	coligation	NN	NN	_	33	nmod	_	_
43	.	.	.	.	_	33	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	CD28	cd28	NN	NN	_	4	compound	_	_
4	coligation	coligation	NN	NN	_	5	nsubj	_	_
5	fails	fail	VBZ	VBZ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	enhance	enhance	VB	VB	_	5	xcomp	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	promoter-reporter	promoter-reporter	NN	NN	_	7	dobj	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	RE/AP	re/ap	NN	NN	_	13	compound	_	_
12	construct	construct	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	9	conj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	CD2-activated	cd2-activated	JJ	JJ	_	16	amod	_	_
16	LPMC	lpmc	NN	NN	_	9	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	5	nsubj	_	_
3	reported	report	VBN	VBN	_	2	acl	_	_
4	herein	herein	RB	RB	_	3	advmod	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	24	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	24	nsubj	_	_
10	involved	involve	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	13	case	_	_
12	CD28	cd28	NN	NN	_	13	compound	_	_
13	cosignaling	cosignaling	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	regulation	regulation	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	IL-2	il-2	NN	NN	_	18	compound	_	_
18	secretion	secretion	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	LP	lp	NN	NN	_	22	compound	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	are	be	VBP	VBP	_	24	cop	_	_
24	unique	unique	JJ	JJ	_	5	ccomp	_	_
25	to	to	TO	TO	_	27	case	_	_
26	that	that	DT	DT	_	27	det	_	_
27	compartment	compartment	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	differ	differ	VBP	VBP	_	24	conj	_	_
30	from	from	IN	IN	_	31	case	_	_
31	those	those	DT	DT	_	29	nmod	_	_
32	seen	see	VBN	VBN	_	31	acl	_	_
33	in	in	IN	IN	_	37	case	_	_
34	peripheral	peripheral	JJ	JJ	_	37	amod	_	_
35	blood	blood	NN	NN	_	37	compound	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	biological	biological	JJ	JJ	_	6	amod	_	_
6	significance	significance	NN	NN	_	3	dobj	_	_
7	for	for	IN	IN	_	9	case	_	_
8	different	different	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	3	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	initiation	initiation	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	maintenance	maintenance	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	cytokine	cytokine	NN	NN	_	20	compound	_	_
20	repertoire	repertoire	NN	NN	_	16	nmod	_	_
21	found	find	VBN	VBN	_	20	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	mucosa	mucosa	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	anorexia	anorexia	NN	NN	_	5	compound	_	_
5	nervosa	nervosa	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Cushing	cushing	NN	NN	_	9	nmod:poss	_	_
8	's	's	POS	POS	_	9	case	_	_
9	disease	disease	NN	NN	_	5	conj	_	_
10	.	.	.	.	_	2	punct	_	_

1	BACKGROUND	background	NN	NN	_	9	dep	_	_
2	:	:	:	:	_	9	punct	_	_
3	Patients	patient	NNS	NNS	_	9	nsubj	_	_
4	with	with	IN	IN	_	6	case	_	_
5	anorexia	anorexia	NN	NN	_	6	compound	_	_
6	nervosa	nervosa	NN	NN	_	3	nmod	_	_
7	do	do	VBP	VBP	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	display	display	VB	VB	_	0	root	_	_
10	cushingoid	cushingoid	JJ	JJ	_	11	amod	_	_
11	features	feature	NNS	NNS	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	spite	spite	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	elevated	elevated	JJ	JJ	_	18	amod	_	_
16	cortisol	cortisol	NN	NN	_	18	compound	_	_
17	plasma	plasma	NN	NN	_	18	compound	_	_
18	levels	level	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Whether	whether	IN	IN	_	21	mark	_	_
2	a	a	DT	DT	_	4	det	_	_
3	cortisol	cortisol	NN	NN	_	4	compound	_	_
4	resistance	resistance	NN	NN	_	21	nsubj	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	a	a	DT	DT	_	8	det	_	_
7	reduced	reduce	VBN	VBN	_	8	amod	_	_
8	availability	availability	NN	NN	_	4	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	metabolic	metabolic	JJ	JJ	_	12	amod	_	_
12	substrates	substrate	NNS	NNS	_	4	nmod	_	_
13	necessary	necessary	JJ	JJ	_	4	amod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	develop	develop	VB	VB	_	13	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	effect	effect	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	glucocorticoids	glucocorticoid	NNS	NNS	_	17	nmod	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	responsible	responsible	JJ	JJ	_	27	csubjpass	_	_
22	for	for	IN	IN	_	23	case	_	_
23	this	this	DT	DT	_	21	nmod	_	_
24	has	have	VBZ	VBZ	_	27	aux	_	_
25	not	not	RB	RB	_	27	neg	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	established	establish	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	METHODS	method	NNS	NNS	_	30	dep	_	_
2	:	:	:	:	_	30	punct	_	_
3	Twenty-two	twenty-two	CD	CD	_	4	nummod	_	_
4	patients	patient	NNS	NNS	_	30	nsubjpass	_	_
5	with	with	IN	IN	_	9	case	_	_
6	severe	severe	JJ	JJ	_	9	amod	_	_
7	restrictive	restrictive	JJ	JJ	_	9	amod	_	_
8	anorexia	anorexia	NN	NN	_	9	compound	_	_
9	nervosa	nervosa	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	4	punct	_	_
11	10	10	CD	CD	_	12	nummod	_	_
12	patients	patient	NNS	NNS	_	4	conj	_	_
13	with	with	IN	IN	_	17	case	_	_
14	active	active	JJ	JJ	_	17	amod	_	_
15	Cushing	cushing	NN	NN	_	17	nmod:poss	_	_
16	's	's	POS	POS	_	17	case	_	_
17	disease	disease	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	4	punct	_	_
19	and	and	CC	CC	_	4	cc	_	_
20	24	24	CD	CD	_	22	nummod	_	_
21	healthy	healthy	JJ	JJ	_	22	amod	_	_
22	volunteers	volunteer	NNS	NNS	_	4	conj	_	_
23	without	without	IN	IN	_	25	case	_	_
24	psychiatric	psychiatric	JJ	JJ	_	25	amod	_	_
25	disorders	disorder	NNS	NNS	_	22	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	mood	mood	NN	NN	_	28	compound	_	_
28	alterations	alteration	NNS	NNS	_	25	conj	_	_
29	were	be	VBD	VBD	_	30	auxpass	_	_
30	investigated	investigate	VBN	VBN	_	0	root	_	_
31	.	.	.	.	_	30	punct	_	_

1	Glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
2	receptor	receptor	NN	NN	_	3	compound	_	_
3	characteristics	characteristic	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	on	on	IN	IN	_	8	case	_	_
7	mononuclear	mononuclear	JJ	JJ	_	8	amod	_	_
8	leukocytes	leukocyte	NNS	NNS	_	5	nmod	_	_
9	by	by	IN	IN	_	10	mark	_	_
10	measuring	measure	VBG	VBG	_	5	advcl	_	_
11	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	12	compound	_	_
12	binding	binding	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	15	det	_	_
15	effect	effect	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	dexamethasone	dexamethasone	NN	NN	_	15	nmod	_	_
18	on	on	IN	IN	_	20	case	_	_
19	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	20	compound	_	_
20	incorporation	incorporation	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	which	which	WDT	WDT	_	23	nsubj	_	_
23	represents	represent	VBZ	VBZ	_	20	acl:relcl	_	_
24	an	a	DT	DT	_	25	det	_	_
25	index	index	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	DNA	dna	NN	NN	_	28	compound	_	_
28	synthesis	synthesis	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	RESULTS	result	NNS	NNS	_	15	nsubj	_	_
2	:	:	:	:	_	15	punct	_	_
3	The	the	DT	DT	_	4	det	_	_
4	number	number	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	7	compound	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	mononuclear	mononuclear	JJ	JJ	_	10	amod	_	_
10	leukocytes	leukocyte	NNS	NNS	_	7	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MNL	mnl	NNS	NNS	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	was	be	VBD	VBD	_	15	cop	_	_
15	comparable	comparable	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	anorexia	anorexia	NN	NN	_	20	compound	_	_
20	nervosa	nervosa	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	17	punct	_	_
22	patients	patient	NNS	NNS	_	17	conj	_	_
23	with	with	IN	IN	_	27	case	_	_
24	active	active	JJ	JJ	_	27	amod	_	_
25	Cushing	cushing	NN	NN	_	27	nmod:poss	_	_
26	's	's	POS	POS	_	27	case	_	_
27	disease	disease	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	17	punct	_	_
29	and	and	CC	CC	_	17	cc	_	_
30	normal	normal	JJ	JJ	_	31	amod	_	_
31	subjects	subject	NNS	NNS	_	17	conj	_	_
32	(	(	-LRB-	-LRB-	_	34	punct	_	_
33	binding	binding	NN	NN	_	34	compound	_	_
34	capacity	capacity	NN	NN	_	31	dep	_	_
35	3.3	3.3	CD	CD	_	34	nummod	_	_
36	+/-	+/-	CC	CC	_	34	cc	_	_
37	0.23	0.23	CD	CD	_	34	conj	_	_
38	vs.	vs.	CC	CC	_	34	cc	_	_
39	3.7	3.7	CD	CD	_	34	conj	_	_
40	+/-	+/-	CC	CC	_	39	cc	_	_
41	0.30	0.30	CD	CD	_	39	conj	_	_
42	and	and	CC	CC	_	39	cc	_	_
43	3.5	3.5	CD	CD	_	39	conj	_	_
44	+/-	+/-	CC	CC	_	43	cc	_	_
45	0.20	0.20	CD	CD	_	43	conj	_	_
46	fmol/10(6)	fmol/10(6)	NN	NN	_	47	compound	_	_
47	cells	cell	NNS	NNS	_	39	dep	_	_
48	)	)	-RRB-	-RRB-	_	34	punct	_	_
49	.	.	.	.	_	15	punct	_	_

1	Conversely	conversely	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	affinity	affinity	NN	NN	_	8	nsubjpass	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	decreased	decrease	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	anorexia	anorexia	NN	NN	_	11	compound	_	_
11	nervosa	nervosa	NN	NN	_	8	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	in	in	IN	IN	_	18	case	_	_
16	Cushing	cushing	NN	NN	_	18	nmod:poss	_	_
17	's	's	POS	POS	_	18	case	_	_
18	patients	patient	NNS	NNS	_	11	conj	_	_
19	compared	compare	VBN	VBN	_	41	case	_	_
20	to	to	TO	TO	_	41	case	_	_
21	control	control	JJ	JJ	_	41	case	_	_
22	subjects	subject	NNS	NNS	_	41	dep	_	_
23	(	(	-LRB-	-LRB-	_	41	punct	_	_
24	dissociation	dissociation	NN	NN	_	25	compound	_	_
25	constant	constant	NN	NN	_	41	dep	_	_
26	4.0	4.0	CD	CD	_	25	dep	_	_
27	+/-	+/-	CC	CC	_	26	cc	_	_
28	0.31	0.31	CD	CD	_	26	conj	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	4.1	4.1	CD	CD	_	26	conj	_	_
31	+/-	+/-	CC	CC	_	30	cc	_	_
32	0.34	0.34	CD	CD	_	30	conj	_	_
33	vs.	vs.	CC	CC	_	25	cc	_	_
34	2.9	2.9	CD	CD	_	37	nummod	_	_
35	+/-	+/-	CC	CC	_	34	cc	_	_
36	0.29	0.29	CD	CD	_	34	conj	_	_
37	nmol/L	nmol/l	NN	NN	_	25	conj	_	_
38	,	,	,	,	_	41	punct	_	_
39	p	p	NN	NN	_	41	nsubj	_	_
40	&lt;	&lt;	JJR	JJR	_	41	dep	_	_
41	.001	.001	CD	CD	_	8	advcl	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	and	and	CC	CC	_	8	cc	_	_
44	inversely	inversely	RB	RB	_	45	advmod	_	_
45	correlated	correlate	VBN	VBN	_	8	conj	_	_
46	with	with	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	levels	level	NNS	NNS	_	45	nmod	_	_
49	of	of	IN	IN	_	52	case	_	_
50	urinary	urinary	JJ	JJ	_	52	amod	_	_
51	free	free	JJ	JJ	_	52	amod	_	_
52	cortisol	cortisol	NN	NN	_	48	nmod	_	_
53	in	in	IN	IN	_	55	case	_	_
54	both	both	DT	DT	_	55	det	_	_
55	groups	group	NNS	NNS	_	48	nmod	_	_
56	of	of	IN	IN	_	57	case	_	_
57	patients	patient	NNS	NNS	_	55	nmod	_	_
58	.	.	.	.	_	8	punct	_	_

1	Basal	basal	JJ	JJ	_	3	amod	_	_
2	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	3	compound	_	_
3	incorporation	incorporation	NN	NN	_	8	nsubjpass	_	_
4	in	in	IN	IN	_	5	case	_	_
5	MNL	mnl	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	8	auxpass	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	reduced	reduce	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	anorexia	anorexia	NN	NN	_	11	compound	_	_
11	nervosa	nervosa	NN	NN	_	8	nmod	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	in	in	IN	IN	_	18	case	_	_
16	Cushing	cushing	NN	NN	_	18	nmod:poss	_	_
17	's	's	POS	POS	_	18	case	_	_
18	patients	patient	NNS	NNS	_	11	conj	_	_
19	compared	compare	VBN	VBN	_	22	case	_	_
20	to	to	TO	TO	_	22	case	_	_
21	control	control	JJ	JJ	_	22	amod	_	_
22	subjects	subject	NNS	NNS	_	8	advcl	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	p	p	NN	NN	_	26	nsubj	_	_
25	&lt;	&lt;	JJR	JJR	_	26	dep	_	_
26	.001	.001	CD	CD	_	8	parataxis	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	8	cc	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	diminished	diminish	VBN	VBN	_	8	conj	_	_
31	by	by	IN	IN	_	32	case	_	_
32	dexamethasone	dexamethasone	NN	NN	_	30	nmod	_	_
33	to	to	TO	TO	_	35	case	_	_
34	an	a	DT	DT	_	35	det	_	_
35	extent	extent	NN	NN	_	30	nmod	_	_
36	similar	similar	JJ	JJ	_	35	dep	_	_
37	to	to	TO	TO	_	39	case	_	_
38	control	control	JJ	JJ	_	39	amod	_	_
39	subjects	subject	NNS	NNS	_	36	nmod	_	_
40	in	in	IN	IN	_	41	case	_	_
41	patients	patient	NNS	NNS	_	39	nmod	_	_
42	with	with	IN	IN	_	44	case	_	_
43	anorexia	anorexia	NN	NN	_	44	compound	_	_
44	nervosa	nervosa	NN	NN	_	41	nmod	_	_
45	,	,	,	,	_	30	punct	_	_
46	but	but	CC	CC	_	30	cc	_	_
47	significantly	significantly	RB	RB	_	53	advmod	_	_
48	(	(	-LRB-	-LRB-	_	51	punct	_	_
49	p	p	NN	NN	_	51	nsubj	_	_
50	&lt;	&lt;	JJR	JJR	_	51	dep	_	_
51	.001	.001	CD	CD	_	53	dep	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	less	less	RBR	RBR	_	30	conj	_	_
54	in	in	IN	IN	_	55	case	_	_
55	those	those	DT	DT	_	53	nmod	_	_
56	with	with	IN	IN	_	59	case	_	_
57	Cushing	cushing	NN	NN	_	59	nmod:poss	_	_
58	's	's	POS	POS	_	59	case	_	_
59	disease	disease	NN	NN	_	55	nmod	_	_
60	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	patients	patient	NNS	NNS	_	16	nmod	_	_
3	with	with	IN	IN	_	5	case	_	_
4	anorexia	anorexia	NN	NN	_	5	compound	_	_
5	nervosa	nervosa	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	16	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	incorporation	incorporation	NN	NN	_	16	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	-LSB-3H-RSB-thymidine	-lsb-3h-rsb-thymidine	NN	NN	_	8	nmod	_	_
11	into	into	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	MNL	mnl	NN	NN	_	8	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	inversely	inversely	RB	RB	_	16	advmod	_	_
16	correlated	correlate	VBN	VBN	_	0	root	_	_
17	with	with	IN	IN	_	21	case	_	_
18	urinary	urinary	JJ	JJ	_	21	amod	_	_
19	free	free	JJ	JJ	_	21	amod	_	_
20	cortisol	cortisol	NN	NN	_	21	compound	_	_
21	levels	level	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	16	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	5	dep	_	_
2	:	:	:	:	_	5	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	19	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	lack	lack	NN	NN	_	19	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	cushingoid	cushingoid	JJ	JJ	_	11	amod	_	_
11	features	feature	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	8	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	anorexia	anorexia	NN	NN	_	16	compound	_	_
16	nervosa	nervosa	NN	NN	_	13	nmod	_	_
17	is	be	VBZ	VBZ	_	19	cop	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	ascribable	ascribable	JJ	JJ	_	5	ccomp	_	_
20	to	to	TO	TO	_	23	case	_	_
21	a	a	DT	DT	_	23	det	_	_
22	reduced	reduce	VBN	VBN	_	23	amod	_	_
23	sensitivity	sensitivity	NN	NN	_	19	nmod	_	_
24	to	to	TO	TO	_	25	case	_	_
25	glucocorticoids	glucocorticoid	NNS	NNS	_	23	nmod	_	_
26	but	but	CC	CC	_	19	cc	_	_
27	is	be	VBZ	VBZ	_	30	cop	_	_
28	more	more	RBR	RBR	_	29	advmod	_	_
29	likely	likely	RB	RB	_	30	advmod	_	_
30	due	due	JJ	JJ	_	19	conj	_	_
31	to	to	TO	TO	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	paucity	paucity	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	36	case	_	_
35	metabolic	metabolic	JJ	JJ	_	36	amod	_	_
36	substrates	substrate	NNS	NNS	_	33	nmod	_	_
37	.	.	.	.	_	5	punct	_	_

1	Latent	latent	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	8	nsubj	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
7	virus	virus	NN	NN	_	3	nmod	_	_
8	interacts	interact	VBZ	VBZ	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	JAK3	jak3	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	activates	activate	VBZ	VBZ	_	8	conj	_	_
13	STAT	stat	NN	NN	_	14	compound	_	_
14	proteins	protein	NNS	NNS	_	12	dobj	_	_
15	.	.	.	.	_	8	punct	_	_

1	Latent	latent	JJ	JJ	_	3	amod	_	_
2	membrane	membrane	NN	NN	_	3	compound	_	_
3	protein	protein	NN	NN	_	8	nsubj	_	_
4	1	1	CD	CD	_	3	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LMP1	lmp1	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	acts	act	VBZ	VBZ	_	0	root	_	_
9	like	like	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	permanently	permanently	RB	RB	_	13	advmod	_	_
12	activated	activate	VBN	VBN	_	13	amod	_	_
13	receptor	receptor	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	23	case	_	_
15	the	the	DT	DT	_	23	det	_	_
16	tumor	tumor	NN	NN	_	18	compound	_	_
17	necrosis	necrosis	NN	NN	_	18	compound	_	_
18	factor	factor	NN	NN	_	23	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	TNF	tnf	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	-receptor	-receptor	NN	NN	_	23	compound	_	_
23	superfamily	superfamily	NN	NN	_	13	nmod	_	_
24	and	and	CC	CC	_	8	cc	_	_
25	is	be	VBZ	VBZ	_	27	auxpass	_	_
26	absolutely	absolutely	RB	RB	_	27	advmod	_	_
27	required	require	VBN	VBN	_	8	conj	_	_
28	for	for	IN	IN	_	31	case	_	_
29	B	b	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	immortalization	immortalization	NN	NN	_	27	nmod	_	_
32	by	by	IN	IN	_	34	case	_	_
33	Epstein-Barr	epstein-barr	JJ	JJ	_	34	amod	_	_
34	virus	virus	NN	NN	_	27	nmod	_	_
35	.	.	.	.	_	8	punct	_	_

1	Molecular	molecular	JJ	JJ	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	biochemical	biochemical	JJ	JJ	_	1	conj	_	_
4	approaches	approach	NNS	NNS	_	5	nsubj	_	_
5	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	LMP1	lmp1	NN	NN	_	8	nsubj	_	_
8	usurps	usurp	VBZ	VBZ	_	5	ccomp	_	_
9	cellular	cellular	JJ	JJ	_	11	amod	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	pathways	pathway	NNS	NNS	_	8	dobj	_	_
12	resulting	result	VBG	VBG	_	11	acl	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	induction	induction	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	AP-1	ap-1	NN	NN	_	17	conj	_	_
20	via	via	IN	IN	_	24	case	_	_
21	two	two	CD	CD	_	24	nummod	_	_
22	C-terminal	c-terminal	JJ	JJ	_	24	amod	_	_
23	activating	activate	VBG	VBG	_	24	amod	_	_
24	regions	region	NNS	NNS	_	15	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	a	a	DT	DT	_	7	det	_	_
6	third	third	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	24	nsubjpass	_	_
8	encompassing	encompass	VBG	VBG	_	7	acl	_	_
9	a	a	DT	DT	_	12	det	_	_
10	proline	proline	NN	NN	_	12	compound	_	_
11	rich	rich	JJ	JJ	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	8	dobj	_	_
13	within	within	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	33	33	CD	CD	_	18	nummod	_	_
16	bp	bp	NN	NN	_	18	compound	_	_
17	repetitive	repetitive	JJ	JJ	_	18	amod	_	_
18	stretch	stretch	NN	NN	_	8	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	LMP1	lmp1	NN	NN	_	22	nmod:poss	_	_
21	's	's	POS	POS	_	20	case	_	_
22	C-terminus	c-terminus	NN	NN	_	18	nmod	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	2	ccomp	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	activation	activation	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	Janus	janus	NN	NN	_	30	compound	_	_
30	kinase	kinase	NN	NN	_	27	nmod	_	_
31	3	3	CD	CD	_	30	nummod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	JAK3	jak3	NN	NN	_	30	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	interaction	interaction	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	LMP1	lmp1	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	JAK3	jak3	NN	NN	_	4	conj	_	_
7	leads	lead	VBZ	VBZ	_	0	root	_	_
8	to	to	TO	TO	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	enhanced	enhance	VBN	VBN	_	12	amod	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	auto/transphosphorylation	auto/transphosphorylation	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	JAK3	jak3	NN	NN	_	12	nmod	_	_
15	within	within	IN	IN	_	16	case	_	_
16	minutes	minute	NNS	NNS	_	7	nmod	_	_
17	after	after	IN	IN	_	18	case	_	_
18	crosslinking	crosslinking	NN	NN	_	16	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	a	a	DT	DT	_	23	det	_	_
21	conditional	conditional	JJ	JJ	_	23	amod	_	_
22	NGF-R:LMP1	ngf-r:lmp1	NN	NN	_	23	compound	_	_
23	chimera	chimera	NN	NN	_	18	nmod	_	_
24	and	and	CC	CC	_	7	cc	_	_
25	is	be	VBZ	VBZ	_	27	cop	_	_
26	a	a	DT	DT	_	27	det	_	_
27	prerequisite	prerequisite	NN	NN	_	7	conj	_	_
28	for	for	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	activation	activation	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	STAT	stat	NN	NN	_	34	compound	_	_
33	transcription	transcription	NN	NN	_	34	compound	_	_
34	factors	factor	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	novel	novel	JJ	JJ	_	7	amod	_	_
6	activating	activate	VBG	VBG	_	7	amod	_	_
7	region	region	NN	NN	_	3	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	LMP1	lmp1	NN	NN	_	11	compound	_	_
11	C-terminus	c-terminus	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	identify	identify	VBP	VBP	_	3	conj	_	_
14	the	the	DT	DT	_	16	det	_	_
15	JAK/STAT	jak/stat	NN	NN	_	16	compound	_	_
16	pathway	pathway	NN	NN	_	13	dobj	_	_
17	as	as	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	target	target	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	25	case	_	_
21	this	this	DT	DT	_	25	det	_	_
22	viral	viral	JJ	JJ	_	25	amod	_	_
23	integral	integral	JJ	JJ	_	25	amod	_	_
24	membrane	membrane	NN	NN	_	25	compound	_	_
25	protein	protein	NN	NN	_	19	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	B	b	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Repression	repression	NN	NN	_	7	nsubjpass	_	_
2	by	by	IN	IN	_	3	case	_	_
3	Ikaros	ikaros	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Aiolos	aiolos	NN	NN	_	3	conj	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	through	through	IN	IN	_	11	case	_	_
9	histone	histone	NN	NN	_	11	compound	_	_
10	deacetylase	deacetylase	NN	NN	_	11	compound	_	_
11	complexes	complex	NNS	NNS	_	7	nmod	_	_
12	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
7	lineage-determining	lineage-determining	JJ	JJ	_	8	amod	_	_
8	factors	factor	NNS	NNS	_	13	nsubj	_	_
9	Ikaros	ikaros	NN	NN	_	8	dep	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Aiolos	aiolos	NN	NN	_	9	conj	_	_
12	can	can	MD	MD	_	13	aux	_	_
13	function	function	VB	VB	_	3	ccomp	_	_
14	as	as	IN	IN	_	17	case	_	_
15	strong	strong	JJ	JJ	_	17	amod	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	repressors	repressor	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	function	function	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	through	through	IN	IN	_	8	case	_	_
6	two	two	CD	CD	_	8	nummod	_	_
7	repression	repression	NN	NN	_	8	compound	_	_
8	domains	domain	NNS	NNS	_	4	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	dependent	dependent	JJ	JJ	_	4	conj	_	_
12	upon	upon	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	dep	_	_
14	promoter	promoter	NN	NN	_	15	compound	_	_
15	context	context	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	type	type	NN	NN	_	15	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	Repression	repression	NN	NN	_	5	nsubj	_	_
2	by	by	IN	IN	_	4	case	_	_
3	Ikaros	ikaros	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	1	nmod	_	_
5	correlates	correlate	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	7	case	_	_
7	hypo-acetylation	hypo-acetylation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	core	core	NN	NN	_	10	compound	_	_
10	histones	histone	NNS	NNS	_	7	nmod	_	_
11	at	at	IN	IN	_	13	case	_	_
12	promoter	promoter	NN	NN	_	13	compound	_	_
13	sites	site	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	relieved	relieve	VBN	VBN	_	5	conj	_	_
17	by	by	IN	IN	_	20	case	_	_
18	histone	histone	NN	NN	_	20	compound	_	_
19	deacetylase	deacetylase	NN	NN	_	20	compound	_	_
20	inhibitors	inhibitor	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	5	punct	_	_

1	Consistent	consistent	JJ	JJ	_	12	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	Ikaros	ikaros	NN	NN	_	12	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	repression	repression	NN	NN	_	10	compound	_	_
10	domains	domain	NNS	NNS	_	6	conj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	interact	interact	VB	VB	_	0	root	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vivo	vivo	FW	FW	_	15	advmod	_	_
15	and	and	CC	CC	_	12	advmod	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	15	advmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	mSin3	msin3	NN	NN	_	21	compound	_	_
21	family	family	NN	NN	_	12	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	co-repressors	co-repressor	NNS	NNS	_	21	nmod	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	bind	bind	VBP	VBP	_	23	acl:relcl	_	_
26	to	to	TO	TO	_	28	case	_	_
27	histone	histone	NN	NN	_	28	compound	_	_
28	deacetylases	deacetylase	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	12	punct	_	_

1	Based	base	VBN	VBN	_	16	advcl	_	_
2	on	on	IN	IN	_	3	case	_	_
3	these	these	DT	DT	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	our	we	PRP$	PRP$	_	7	nmod:poss	_	_
6	recent	recent	JJ	JJ	_	7	amod	_	_
7	findings	finding	NNS	NNS	_	3	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	associations	association	NNS	NNS	_	7	nmod	_	_
10	between	between	IN	IN	_	11	case	_	_
11	Ikaros	ikaros	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Mi-2-HDAC	mi-2-hdac	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	16	punct	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	propose	propose	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	21	mark	_	_
18	Ikaros	ikaros	NN	NN	_	20	compound	_	_
19	family	family	NN	NN	_	20	compound	_	_
20	members	member	NNS	NNS	_	21	nsubj	_	_
21	modulate	modulate	VBP	VBP	_	16	ccomp	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	21	dobj	_	_
24	during	during	IN	IN	_	26	case	_	_
25	lymphocyte	lymphocyte	NN	NN	_	26	compound	_	_
26	development	development	NN	NN	_	21	nmod	_	_
27	by	by	IN	IN	_	28	mark	_	_
28	recruiting	recruit	VBG	VBG	_	21	advcl	_	_
29	distinct	distinct	JJ	JJ	_	32	amod	_	_
30	histone	histone	NN	NN	_	32	compound	_	_
31	deacetylase	deacetylase	NN	NN	_	32	compound	_	_
32	complexes	complex	NNS	NNS	_	28	dobj	_	_
33	to	to	TO	TO	_	35	case	_	_
34	specific	specific	JJ	JJ	_	35	amod	_	_
35	promoters	promoter	NNS	NNS	_	28	nmod	_	_
36	.	.	.	.	_	16	punct	_	_

1	20-Epi	20-epi	NN	NN	_	2	compound	_	_
2	analogues	analogue	NNS	NNS	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	5	compound	_	_
5	D3	d3	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	9	cop	_	_
7	highly	highly	RB	RB	_	8	advmod	_	_
8	potent	potent	JJ	JJ	_	9	amod	_	_
9	inducers	inducer	NNS	NNS	_	0	root	_	_
10	of	of	IN	IN	_	13	case	_	_
11	DRIP	drip	NN	NN	_	13	compound	_	_
12	coactivator	coactivator	NN	NN	_	13	compound	_	_
13	complex	complex	NN	NN	_	9	nmod	_	_
14	binding	binding	NN	NN	_	13	dep	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	vitamin	vitamin	NN	NN	_	19	compound	_	_
18	D3	d3	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	1,25-Dihydroxyvitamin	1,25-dihydroxyvitamin	NN	NN	_	2	compound	_	_
2	D3	d3	NN	NN	_	6	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	plays	play	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	major	major	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	stimulation	stimulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	bone	bone	NN	NN	_	15	compound	_	_
15	growth	growth	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	mineralization	mineralization	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	15	punct	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	intestinal	intestinal	JJ	JJ	_	24	amod	_	_
21	calcium	calcium	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	phosphate	phosphate	NN	NN	_	21	conj	_	_
24	absorption	absorption	NN	NN	_	15	conj	_	_
25	;	;	:	:	_	6	punct	_	_
26	it	it	PRP	PRP	_	28	nsubj	_	_
27	also	also	RB	RB	_	28	advmod	_	_
28	acts	act	VBZ	VBZ	_	6	parataxis	_	_
29	as	as	IN	IN	_	32	case	_	_
30	a	a	DT	DT	_	32	det	_	_
31	general	general	JJ	JJ	_	32	amod	_	_
32	inhibitor	inhibitor	NN	NN	_	28	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	cellular	cellular	JJ	JJ	_	35	amod	_	_
35	proliferation	proliferation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	6	punct	_	_

1	Several	several	JJ	JJ	_	6	amod	_	_
2	new	new	JJ	JJ	_	6	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	clinically	clinically	RB	RB	_	5	advmod	_	_
5	relevant	relevant	JJ	JJ	_	2	dep	_	_
6	compounds	compound	NNS	NNS	_	7	nsubj	_	_
7	dissociate	dissociate	VBP	VBP	_	0	root	_	_
8	antiproliferative	antiproliferative	JJ	JJ	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	calcemic	calcemic	JJ	JJ	_	8	conj	_	_
11	activities	activity	NNS	NNS	_	8	dep	_	_
12	of	of	IN	IN	_	13	case	_	_
13	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	but	but	CC	CC	_	7	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	basis	basis	NN	NN	_	25	nsubjpass	_	_
19	for	for	IN	IN	_	20	case	_	_
20	this	this	DT	DT	_	18	nmod	_	_
21	has	have	VBZ	VBZ	_	25	aux	_	_
22	not	not	RB	RB	_	25	neg	_	_
23	been	be	VBN	VBN	_	25	auxpass	_	_
24	clearly	clearly	RB	RB	_	25	advmod	_	_
25	elucidated	elucidate	VBN	VBN	_	7	conj	_	_
26	.	.	.	.	_	7	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	tested	test	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	28	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	potency	potency	NN	NN	_	28	nsubj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	one	one	CD	CD	_	10	nummod	_	_
10	class	class	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	compounds	compound	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	20-epi	20-epi	NN	NN	_	15	compound	_	_
15	analogues	analogue	NNS	NNS	_	12	dep	_	_
16	,	,	,	,	_	15	punct	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	induce	induce	VB	VB	_	12	acl	_	_
19	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	differentiation	differentiation	NN	NN	_	18	dobj	_	_
22	,	,	,	,	_	28	punct	_	_
23	is	be	VBZ	VBZ	_	28	cop	_	_
24	because	because	IN	IN	_	28	case	_	_
25	of	of	IN	IN	_	24	mwe	_	_
26	direct	direct	JJ	JJ	_	28	amod	_	_
27	molecular	molecular	JJ	JJ	_	28	amod	_	_
28	effects	effect	NNS	NNS	_	4	ccomp	_	_
29	on	on	IN	IN	_	32	case	_	_
30	vitamin	vitamin	NN	NN	_	32	compound	_	_
31	D	d	NN	NN	_	32	compound	_	_
32	receptor	receptor	NN	NN	_	28	nmod	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	VDR	vdr	NN	NN	_	32	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	20-epi	20-epi	NN	NN	_	6	compound	_	_
6	analogues	analogue	NNS	NNS	_	12	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	MC1627	mc1627	NN	NN	_	6	appos	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	MC1288	mc1288	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	12	punct	_	_
12	induced	induce	VBD	VBD	_	2	ccomp	_	_
13	differentiation	differentiation	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	transcription	transcription	NN	NN	_	13	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	p21	p21	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	Waf1	waf1	NN	NN	_	17	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	Cip1	cip1	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	,	,	,	,	_	17	punct	_	_
24	a	a	DT	DT	_	28	det	_	_
25	key	key	JJ	JJ	_	28	amod	_	_
26	VDR	vdr	NN	NN	_	28	compound	_	_
27	target	target	NN	NN	_	28	compound	_	_
28	gene	gene	NN	NN	_	17	appos	_	_
29	involved	involve	VBN	VBN	_	28	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	growth	growth	NN	NN	_	32	compound	_	_
32	inhibition	inhibition	NN	NN	_	29	nmod	_	_
33	,	,	,	,	_	12	punct	_	_
34	at	at	IN	IN	_	36	case	_	_
35	a	a	DT	DT	_	36	det	_	_
36	concentration	concentration	NN	NN	_	12	nmod	_	_
37	100-fold	100-fold	RB	RB	_	38	advmod	_	_
38	lower	lower	JJR	JJR	_	36	amod	_	_
39	than	than	IN	IN	_	40	case	_	_
40	that	that	DT	DT	_	38	nmod	_	_
41	of	of	IN	IN	_	42	case	_	_
42	1,25(OH)2D3	1,25(oh)2d3	NN	NN	_	40	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	compared	compare	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	4	det	_	_
4	sensitivity	sensitivity	NN	NN	_	2	dobj	_	_
5	to	to	TO	TO	_	7	case	_	_
6	analogue	analogue	NN	NN	_	7	compound	_	_
7	effects	effect	NNS	NNS	_	4	nmod	_	_
8	on	on	IN	IN	_	11	case	_	_
9	VDR	vdr	NN	NN	_	11	compound	_	_
10	interacting	interacting	NN	NN	_	11	compound	_	_
11	proteins	protein	NNS	NNS	_	7	nmod	_	_
12	:	:	:	:	_	11	punct	_	_
13	RXR	rxr	NN	NN	_	11	dep	_	_
14	,	,	,	,	_	13	punct	_	_
15	GRIP-1	grip-1	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	DRIP205	drip205	NN	NN	_	13	conj	_	_
19	,	,	,	,	_	18	punct	_	_
20	a	a	DT	DT	_	21	det	_	_
21	subunit	subunit	NN	NN	_	18	appos	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	DRIP	drip	NN	NN	_	26	compound	_	_
25	coactivator	coactivator	NN	NN	_	26	compound	_	_
26	complex	complex	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	Compared	compare	VBN	VBN	_	17	advcl	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	interaction	interaction	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	VDR	vdr	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	RXR	rxr	NN	NN	_	4	nmod	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	GRIP-1	grip-1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	17	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	differentiation	differentiation	NN	NN	_	14	compound	_	_
14	dose-response	dose-response	NN	NN	_	17	nsubj	_	_
15	most	most	JJS	JJS	_	16	dep	_	_
16	closely	closely	RB	RB	_	17	advmod	_	_
17	correlated	correlate	VBD	VBD	_	0	root	_	_
18	to	to	TO	TO	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	ligand-dependent	ligand-dependent	JJ	JJ	_	21	amod	_	_
21	recruitment	recruitment	NN	NN	_	17	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	DRIP	drip	NN	NN	_	26	compound	_	_
25	coactivator	coactivator	NN	NN	_	26	compound	_	_
26	complex	complex	NN	NN	_	21	nmod	_	_
27	to	to	TO	TO	_	28	case	_	_
28	VDR	vdr	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	21	cc	_	_
30	to	to	TO	TO	_	32	case	_	_
31	the	the	DT	DT	_	32	det	_	_
32	ability	ability	NN	NN	_	21	conj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	receptor	receptor	NN	NN	_	32	nmod	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	activate	activate	VB	VB	_	32	acl	_	_
38	transcription	transcription	NN	NN	_	37	dobj	_	_
39	in	in	IN	IN	_	42	case	_	_
40	a	a	DT	DT	_	42	det	_	_
41	cell-free	cell-free	JJ	JJ	_	42	amod	_	_
42	system	system	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	compelling	compelling	JJ	JJ	_	5	amod	_	_
5	links	link	NNS	NNS	_	3	dobj	_	_
6	between	between	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	efficiency	efficiency	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	20-epi	20-epi	NN	NN	_	12	compound	_	_
12	analogue	analogue	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	14	mark	_	_
14	inducing	induce	VBG	VBG	_	8	acl	_	_
15	VDR/DRIP	vdr/drip	NN	NN	_	16	compound	_	_
16	interactions	interaction	NNS	NNS	_	14	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	transactivation	transactivation	NN	NN	_	16	appos	_	_
19	in	in	FW	FW	_	18	amod	_	_
20	vitro	vitro	FW	FW	_	19	dep	_	_
21	,	,	,	,	_	8	punct	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	enhanced	enhance	VBN	VBN	_	25	amod	_	_
25	ability	ability	NN	NN	_	8	conj	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	induce	induce	VB	VB	_	25	acl	_	_
28	cellular	cellular	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	3	punct	_	_

1	New	new	JJ	JJ	_	3	amod	_	_
2	immunosuppressive	immunosuppressive	JJ	JJ	_	3	amod	_	_
3	drug	drug	NN	NN	_	5	nsubj	_	_
4	PNU156804	pnu156804	NN	NN	_	3	dep	_	_
5	blocks	block	VBZ	VBZ	_	0	root	_	_
6	IL-2-dependent	il-2-dependent	JJ	JJ	_	7	amod	_	_
7	proliferation	proliferation	NN	NN	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
10	B	b	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	AP-1	ap-1	NN	NN	_	10	conj	_	_
13	activation	activation	NN	NN	_	10	dep	_	_
14	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	had	have	VBD	VBD	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	drug	drug	NN	NN	_	12	nsubj	_	_
8	undecylprodigiosin	undecylprodigiosin	NN	NN	_	7	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	UP	up	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	blocks	block	VBZ	VBZ	_	4	ccomp	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	12	dobj	_	_
16	in	in	FW	FW	_	17	compound	_	_
17	vitro	vitro	FW	FW	_	12	advmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	now	now	RB	RB	_	4	advmod	_	_
4	investigated	investigate	VBN	VBN	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	mechanism	mechanism	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	action	action	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	analogue	analogue	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	UP	up	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	PNU156804	pnu156804	NN	NN	_	14	appos	_	_
17	,	,	,	,	_	12	punct	_	_
18	which	which	WDT	WDT	_	19	nsubj	_	_
19	shows	show	VBZ	VBZ	_	12	acl:relcl	_	_
20	a	a	DT	DT	_	24	det	_	_
21	more	more	RBR	RBR	_	22	advmod	_	_
22	favorable	favorable	JJ	JJ	_	24	amod	_	_
23	activity	activity	NN	NN	_	24	compound	_	_
24	profile	profile	NN	NN	_	19	dobj	_	_
25	than	than	IN	IN	_	26	case	_	_
26	UP	up	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	mice	mouse	NNS	NNS	_	26	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	biological	biological	JJ	JJ	_	7	amod	_	_
7	effect	effect	NN	NN	_	13	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PNU156804	pnu156804	NN	NN	_	7	nmod	_	_
10	in	in	FW	FW	_	7	amod	_	_
11	vitro	vitro	FW	FW	_	10	dep	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	indistinguishable	indistinguishable	JJ	JJ	_	2	ccomp	_	_
14	from	from	IN	IN	_	15	case	_	_
15	UP	up	NN	NN	_	13	nmod	_	_
16	:	:	:	:	_	13	punct	_	_
17	PNU156804	pnu156804	NN	NN	_	18	nsubj	_	_
18	blocks	block	VBZ	VBZ	_	13	parataxis	_	_
19	human	human	JJ	JJ	_	22	amod	_	_
20	T	t	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	proliferation	proliferation	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	mid-late	mid-late	JJ	JJ	_	25	amod	_	_
25	G1	g1	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	18	punct	_	_
27	as	as	IN	IN	_	28	mark	_	_
28	determined	determine	VBN	VBN	_	18	advcl	_	_
29	by	by	IN	IN	_	32	case	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	cycle	cycle	NN	NN	_	32	compound	_	_
32	analysis	analysis	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	expression	expression	NN	NN	_	32	appos	_	_
35	of	of	IN	IN	_	36	case	_	_
36	cyclins	cyclin	NNS	NNS	_	34	nmod	_	_
37	,	,	,	,	_	34	punct	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	cyclin-dependent	cyclin-dependent	JJ	JJ	_	40	amod	_	_
40	kinases	kinase	NNS	NNS	_	34	conj	_	_
41	and	and	CC	CC	_	34	cc	_	_
42	retinoblastoma	retinoblastoma	NN	NN	_	43	compound	_	_
43	phosphorylation	phosphorylation	NN	NN	_	34	conj	_	_
44	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	PNU156804	pnu156804	NN	NN	_	10	nsubj	_	_
8	does	do	VBZ	VBZ	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	block	block	VB	VB	_	5	ccomp	_	_
11	significantly	significantly	RB	RB	_	10	advmod	_	_
12	the	the	DT	DT	_	13	det	_	_
13	induction	induction	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	either	either	DT	DT	_	16	cc:preconj	_	_
16	IL-2	il-2	NN	NN	_	13	nmod	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	IL-2R	il-2r	NN	NN	_	16	conj	_	_
19	alpha-	alpha-	NN	NN	_	18	dep	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	gamma-chains	gamma-chain	NNS	NNS	_	19	conj	_	_
22	but	but	CC	CC	_	10	cc	_	_
23	inhibits	inhibit	VBZ	VBZ	_	10	conj	_	_
24	IL-2-dependent	il-2-dependent	JJ	JJ	_	27	amod	_	_
25	T	t	NN	NN	_	27	compound	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	proliferation	proliferation	NN	NN	_	23	dobj	_	_
28	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	several	several	JJ	JJ	_	6	amod	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	pathways	pathway	NNS	NNS	_	3	dobj	_	_
7	that	that	WDT	WDT	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	known	know	VBN	VBN	_	6	acl:relcl	_	_
10	to	to	TO	TO	_	12	mark	_	_
11	be	be	VB	VB	_	12	auxpass	_	_
12	activated	activate	VBN	VBN	_	9	xcomp	_	_
13	by	by	IN	IN	_	14	case	_	_
14	IL-2	il-2	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	PNU156804	pnu156804	NN	NN	_	7	nsubj	_	_
5	does	do	VBZ	VBZ	_	7	aux	_	_
6	not	not	RB	RB	_	7	neg	_	_
7	inhibit	inhibit	VB	VB	_	2	ccomp	_	_
8	c-myc	c-myc	NN	NN	_	7	dobj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	bcl-2	bcl-2	NN	NN	_	8	conj	_	_
11	mRNA	mrna	NN	NN	_	12	compound	_	_
12	induction	induction	NN	NN	_	8	dep	_	_
13	.	.	.	.	_	2	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	PNU156804	pnu156804	NN	NN	_	8	nsubj	_	_
7	efficiently	efficiently	RB	RB	_	8	advmod	_	_
8	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
9	the	the	DT	DT	_	10	det	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	NF-kappa	nf-kappa	NN	NN	_	14	compound	_	_
14	B	b	NN	NN	_	10	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	AP-1	ap-1	NN	NN	_	14	conj	_	_
17	transcription	transcription	NN	NN	_	18	compound	_	_
18	factors	factor	NNS	NNS	_	14	dep	_	_
19	.	.	.	.	_	8	punct	_	_

1	PNU156804	pnu156804	NN	NN	_	2	compound	_	_
2	inhibition	inhibition	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	NF-kappa	nf-kappa	NN	NN	_	6	compound	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	due	due	JJ	JJ	_	11	case	_	_
9	to	to	TO	TO	_	8	mwe	_	_
10	the	the	DT	DT	_	11	det	_	_
11	inhibition	inhibition	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	degradation	degradation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	I	i	NN	NN	_	18	compound	_	_
17	kappa	kappa	NN	NN	_	18	compound	_	_
18	B-alpha	b-alpha	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	I	i	NN	NN	_	22	compound	_	_
21	kappa	kappa	NN	NN	_	22	compound	_	_
22	B-beta	b-beta	NN	NN	_	18	conj	_	_
23	.	.	.	.	_	11	punct	_	_

1	PNU156804	pnu156804	NN	NN	_	2	compound	_	_
2	action	action	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	restricted	restricted	JJ	JJ	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	some	some	DT	DT	_	8	det	_	_
7	signaling	signaling	NN	NN	_	8	compound	_	_
8	pathways	pathway	NNS	NNS	_	4	nmod	_	_
9	;	;	:	:	_	4	punct	_	_
10	it	it	PRP	PRP	_	13	nsubj	_	_
11	does	do	VBZ	VBZ	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	affect	affect	VB	VB	_	4	parataxis	_	_
14	NF-kappa	nf-kappa	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	13	dobj	_	_
17	by	by	IN	IN	_	18	case	_	_
18	PMA	pma	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	but	but	CC	CC	_	13	cc	_	_
23	blocks	block	VBZ	VBZ	_	13	conj	_	_
24	that	that	DT	DT	_	23	dobj	_	_
25	induced	induce	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	CD40	cd40	NN	NN	_	28	compound	_	_
28	cross-linking	cross-linking	NN	NN	_	25	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	B	b	NN	NN	_	31	compound	_	_
31	lymphocytes	lymphocyte	NNS	NNS	_	28	nmod	_	_
32	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	12	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	prodigiosin	prodigiosin	NN	NN	_	6	compound	_	_
6	family	family	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	immunosuppressants	immunosuppressant	NNS	NNS	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	new	new	JJ	JJ	_	12	amod	_	_
12	family	family	NN	NN	_	2	ccomp	_	_
13	of	of	IN	IN	_	14	case	_	_
14	molecules	molecule	NNS	NNS	_	12	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	show	show	VBP	VBP	_	14	acl:relcl	_	_
17	a	a	DT	DT	_	20	det	_	_
18	novel	novel	JJ	JJ	_	20	amod	_	_
19	target	target	NN	NN	_	20	compound	_	_
20	specificity	specificity	NN	NN	_	16	dobj	_	_
21	clearly	clearly	RB	RB	_	22	advmod	_	_
22	distinct	distinct	JJ	JJ	_	20	amod	_	_
23	from	from	IN	IN	_	24	case	_	_
24	that	that	DT	DT	_	22	nmod	_	_
25	of	of	IN	IN	_	28	case	_	_
26	other	other	JJ	JJ	_	28	amod	_	_
27	immunosuppressive	immunosuppressive	JJ	JJ	_	28	amod	_	_
28	drugs	drug	NNS	NNS	_	24	nmod	_	_
29	such	such	JJ	JJ	_	32	case	_	_
30	as	as	IN	IN	_	29	mwe	_	_
31	cyclosporin	cyclosporin	NN	NN	_	32	compound	_	_
32	A	a	NN	NN	_	28	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	FK506	fk506	NN	NN	_	32	conj	_	_
35	,	,	,	,	_	32	punct	_	_
36	and	and	CC	CC	_	32	cc	_	_
37	rapamycin	rapamycin	NN	NN	_	32	conj	_	_
38	.	.	.	.	_	2	punct	_	_

1	IL-12	il-12	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	IFN	ifn	NN	NN	_	5	compound	_	_
4	regulating	regulating	NN	NN	_	5	compound	_	_
5	factor-1	factor-1	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IRF-1	irf-1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	2	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	NK	nk	NN	NN	_	2	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	T	t	NN	NN	_	13	conj	_	_
16	cells	cell	NNS	NNS	_	13	dep	_	_
17	.	.	.	.	_	2	punct	_	_

1	IL-12	il-12	NN	NN	_	6	nsubj	_	_
2	is	be	VBZ	VBZ	_	6	cop	_	_
3	a	a	DT	DT	_	6	det	_	_
4	critical	critical	JJ	JJ	_	6	amod	_	_
5	immunoregulatory	immunoregulatory	JJ	JJ	_	6	amod	_	_
6	cytokine	cytokine	NN	NN	_	0	root	_	_
7	that	that	WDT	WDT	_	8	nsubj	_	_
8	promotes	promote	VBZ	VBZ	_	6	acl:relcl	_	_
9	cell-mediated	cell-mediated	JJ	JJ	_	11	amod	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	responses	response	NNS	NNS	_	8	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	14	det	_	_
14	differentiation	differentiation	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	naive	naive	JJ	JJ	_	18	amod	_	_
17	CD4+	cd4+	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	Th1	th1	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	14	nmod	_	_
22	;	;	:	:	_	6	punct	_	_
23	however	however	RB	RB	_	32	advmod	_	_
24	,	,	,	,	_	32	punct	_	_
25	relatively	relatively	RB	RB	_	26	advmod	_	_
26	few	few	JJ	JJ	_	29	amod	_	_
27	IL-12	il-12	NN	NN	_	29	compound	_	_
28	target	target	NN	NN	_	29	compound	_	_
29	genes	gene	NNS	NNS	_	32	nsubjpass	_	_
30	have	have	VBP	VBP	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	identified	identify	VBN	VBN	_	6	parataxis	_	_
33	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	3	mark	_	_
2	better	better	RBR	RBR	_	3	advmod	_	_
3	clarify	clarify	VB	VB	_	12	advcl	_	_
4	the	the	DT	DT	_	6	det	_	_
5	molecular	molecular	JJ	JJ	_	6	amod	_	_
6	basis	basis	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	IL-12	il-12	NN	NN	_	9	compound	_	_
9	action	action	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	set	set	VBD	VBD	_	0	root	_	_
13	out	out	RP	RP	_	12	dep	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	characterize	characterize	VB	VB	_	12	xcomp	_	_
16	genes	gene	NNS	NNS	_	15	dobj	_	_
17	up-regulated	up-regulate	VBN	VBN	_	16	acl	_	_
18	by	by	IN	IN	_	19	case	_	_
19	IL-12	il-12	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	first	first	RB	RB	_	23	advmod	_	_
22	by	by	IN	IN	_	23	mark	_	_
23	contrasting	contrast	VBG	VBG	_	15	advcl	_	_
24	IL-12-	il-12-	NN	NN	_	23	dobj	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	IFN-alpha-inducible	ifn-alpha-inducible	JJ	JJ	_	27	amod	_	_
27	genes	gene	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	several	several	JJ	JJ	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	2	dobj	_	_
5	up-regulated	up-regulate	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	IL-12	il-12	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	namely	namely	RB	RB	_	7	advmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	MIP-1alpha	mip-1alpha	NN	NN	_	7	appos	_	_
12	,	,	,	,	_	11	punct	_	_
13	MIP-1beta	mip-1beta	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	IL-1RA	il-1ra	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	IFN	ifn	NN	NN	_	20	compound	_	_
19	regulatory	regulatory	JJ	JJ	_	20	amod	_	_
20	factor-1	factor-1	NN	NN	_	11	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	IRF-1	irf-1	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	.	.	.	.	_	2	punct	_	_

1	IRF-1	irf-1	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	transcription	transcription	NN	NN	_	5	compound	_	_
5	factor	factor	NN	NN	_	0	root	_	_
6	regulated	regulate	VBN	VBN	_	5	acl	_	_
7	by	by	IN	IN	_	8	case	_	_
8	IFNs	ifns	NN	NN	_	6	nmod	_	_
9	that	that	WDT	WDT	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	essential	essential	JJ	JJ	_	8	acl:relcl	_	_
13	for	for	IN	IN	_	15	case	_	_
14	Th1	th1	NN	NN	_	15	compound	_	_
15	responses	response	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	IL-12	il-12	NN	NN	_	6	nsubj	_	_
5	directly	directly	RB	RB	_	6	advmod	_	_
6	up-regulates	up-regulate	VBZ	VBZ	_	2	ccomp	_	_
7	IRF-1	irf-1	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	same	same	JJ	JJ	_	11	amod	_	_
11	extent	extent	NN	NN	_	6	nmod	_	_
12	as	as	IN	IN	_	13	case	_	_
13	IFN-alpha	ifn-alpha	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	normal	normal	JJ	JJ	_	18	amod	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	in	in	IN	IN	_	22	case	_	_
21	NK	nk	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	conj	_	_
23	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	showed	show	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	IL-12	il-12	NN	NN	_	5	nsubj	_	_
5	had	have	VBD	VBD	_	2	ccomp	_	_
6	a	a	DT	DT	_	8	det	_	_
7	direct	direct	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	5	dobj	_	_
9	on	on	IN	IN	_	10	case	_	_
10	IRF-1	irf-1	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	an	a	DT	DT	_	13	det	_	_
13	effect	effect	NN	NN	_	8	appos	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	mediated	mediate	VBN	VBN	_	13	acl	_	_
16	indirectly	indirectly	RB	RB	_	15	advmod	_	_
17	by	by	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	induction	induction	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	production	production	NN	NN	_	19	nmod	_	_
23	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	IL-2	il-2	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	IL-12	il-12	NN	NN	_	3	conj	_	_
6	synergistically	synergistically	RB	RB	_	7	advmod	_	_
7	induced	induce	VBD	VBD	_	0	root	_	_
8	IRF-1	irf-1	NN	NN	_	7	dobj	_	_
9	,	,	,	,	_	7	punct	_	_
10	whereas	whereas	IN	IN	_	7	dep	_	_
11	IFN-alpha	ifn-alpha	NN	NN	_	14	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-12	il-12	NN	NN	_	11	conj	_	_
14	did	do	VBD	VBD	_	7	parataxis	_	_
15	not	not	RB	RB	_	14	neg	_	_
16	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	participation	participation	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT4	stat4	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	regulation	regulation	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IRF-1	irf-1	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	two	two	CD	CD	_	14	nummod	_	_
14	ways	way	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	11	punct	_	_

1	First	first	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	STAT4	stat4	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	required	require	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	IL-12-dependent	il-12-dependent	JJ	JJ	_	9	amod	_	_
9	transactivation	transactivation	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	an	a	DT	DT	_	14	det	_	_
12	IRF-1	irf-1	NN	NN	_	14	compound	_	_
13	reporter	reporter	NN	NN	_	14	compound	_	_
14	construct	construct	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	5	punct	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	second	second	RB	RB	_	5	advmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	STAT4	stat4	NN	NN	_	26	nsubjpass	_	_
20	binding	bind	VBG	VBG	_	19	acl	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	IRF-1	irf-1	NN	NN	_	24	compound	_	_
24	promoter	promoter	NN	NN	_	20	nmod	_	_
25	was	be	VBD	VBD	_	26	auxpass	_	_
26	shown	show	VBN	VBN	_	5	ccomp	_	_
27	using	use	VBG	VBG	_	26	xcomp	_	_
28	EMSA	emsa	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	11	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	IL-12	il-12	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	no	no	DT	DT	_	7	neg	_	_
7	up-regulation	up-regulation	NN	NN	_	11	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	IRF-1	irf-1	NN	NN	_	7	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	IL-4-stimulated	il-4-stimulated	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	IL-4	il-4	NN	NN	_	20	nsubj	_	_
18	did	do	VBD	VBD	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	block	block	VB	VB	_	11	conj	_	_
21	IL-12-dependent	il-12-dependent	JJ	JJ	_	22	amod	_	_
22	up-regulation	up-regulation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IRF-1	irf-1	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	Therefore	therefore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	IRF-1	irf-1	NN	NN	_	8	nsubj	_	_
4	may	may	MD	MD	_	8	aux	_	_
5	be	be	VB	VB	_	8	cop	_	_
6	an	a	DT	DT	_	8	det	_	_
7	important	important	JJ	JJ	_	8	amod	_	_
8	contributor	contributor	NN	NN	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	IL-12	il-12	NN	NN	_	11	compound	_	_
11	signaling	signaling	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	speculate	speculate	VBP	VBP	_	8	conj	_	_
16	that	that	IN	IN	_	27	mark	_	_
17	the	the	DT	DT	_	20	det	_	_
18	defective	defective	JJ	JJ	_	20	amod	_	_
19	IL-12	il-12	NN	NN	_	20	compound	_	_
20	responses	response	NNS	NNS	_	27	nsubj	_	_
21	seen	see	VBN	VBN	_	20	acl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	IRF-1-/-	irf-1-/-	JJ	JJ	_	24	amod	_	_
24	mice	mouse	NNS	NNS	_	21	nmod	_	_
25	might	might	MD	MD	_	27	aux	_	_
26	be	be	VB	VB	_	27	cop	_	_
27	attributable	attributable	JJ	JJ	_	15	ccomp	_	_
28	,	,	,	,	_	27	punct	_	_
29	in	in	IN	IN	_	30	case	_	_
30	part	part	NN	NN	_	27	nmod	_	_
31	,	,	,	,	_	27	punct	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	absence	absence	NN	NN	_	27	nmod	_	_
35	of	of	IN	IN	_	38	case	_	_
36	this	this	DT	DT	_	38	det	_	_
37	transcription	transcription	NN	NN	_	38	compound	_	_
38	factor	factor	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	8	punct	_	_

1	Multiple	multiple	JJ	JJ	_	3	amod	_	_
2	NF-ATc	nf-atc	NN	NN	_	3	compound	_	_
3	isoforms	isoform	NNS	NNS	_	9	nsubjpass	_	_
4	with	with	IN	IN	_	7	case	_	_
5	individual	individual	JJ	JJ	_	7	amod	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	properties	property	NNS	NNS	_	3	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	synthesized	synthesize	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	17	nsubjpass	_	_
4	NF-ATc	nf-atc	NN	NN	_	3	dep	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	controls	control	VBZ	VBZ	_	3	acl:relcl	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	embryonic	embryonic	JJ	JJ	_	15	amod	_	_
14	cardiac	cardiac	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	conj	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	expressed	express	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	21	case	_	_
19	three	three	CD	CD	_	21	nummod	_	_
20	prominent	prominent	JJ	JJ	_	21	amod	_	_
21	isoforms	isoform	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	due	due	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	alternative	alternative	JJ	JJ	_	7	amod	_	_
6	splice/polyadenylation	splice/polyadenylation	NN	NN	_	7	compound	_	_
7	events	event	NNS	NNS	_	3	nmod	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	lead	lead	VBP	VBP	_	7	acl:relcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	predominant	predominant	JJ	JJ	_	13	amod	_	_
13	synthesis	synthesis	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	two	two	CD	CD	_	17	nummod	_	_
16	long	long	JJ	JJ	_	17	amod	_	_
17	isoforms	isoform	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	naive	naive	JJ	JJ	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	and	and	CC	CC	_	17	cc	_	_
23	a	a	DT	DT	_	26	det	_	_
24	shorter	shorter	JJR	JJR	_	26	amod	_	_
25	NF-ATc	nf-atc	NN	NN	_	26	compound	_	_
26	isoform	isoform	NN	NN	_	17	conj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	effector	effector	NN	NN	_	30	compound	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	26	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Whereas	whereas	IN	IN	_	7	mark	_	_
2	the	the	DT	DT	_	6	det	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	described	describe	VBN	VBN	_	6	amod	_	_
5	isoform	isoform	NN	NN	_	6	compound	_	_
6	NF-ATc/A	nf-atc/a	NN	NN	_	7	nsubj	_	_
7	contains	contain	VBZ	VBZ	_	22	advcl	_	_
8	a	a	DT	DT	_	12	det	_	_
9	relatively	relatively	RB	RB	_	10	advmod	_	_
10	short	short	JJ	JJ	_	12	amod	_	_
11	C	c	NN	NN	_	12	compound	_	_
12	terminus	terminus	NN	NN	_	7	dobj	_	_
13	,	,	,	,	_	22	punct	_	_
14	the	the	DT	DT	_	16	det	_	_
15	longer	longer	JJR	JJR	_	16	amod	_	_
16	isoforms	isoform	NNS	NNS	_	22	nsubj	_	_
17	,	,	,	,	_	16	punct	_	_
18	B	b	NN	NN	_	16	appos	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	C	c	NN	NN	_	18	conj	_	_
21	,	,	,	,	_	22	punct	_	_
22	span	span	VBP	VBP	_	0	root	_	_
23	extra	extra	JJ	JJ	_	25	amod	_	_
24	C-terminal	c-terminal	JJ	JJ	_	25	amod	_	_
25	peptides	peptide	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	128	128	CD	CD	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	246	246	CD	CD	_	27	conj	_	_
30	aa	aa	NN	NN	_	27	dep	_	_
31	,	,	,	,	_	22	punct	_	_
32	respectively	respectively	RB	RB	_	22	advmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	26	mark	_	_
5	in	in	IN	IN	_	6	case	_	_
6	addition	addition	NN	NN	_	26	nmod	_	_
7	to	to	TO	TO	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	strong	strong	JJ	JJ	_	12	amod	_	_
10	N-terminal	n-terminal	JJ	JJ	_	12	amod	_	_
11	trans-activation	trans-activation	NN	NN	_	12	compound	_	_
12	domain	domain	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	TAD-A	tad-a	NN	NN	_	12	appos	_	_
15	,	,	,	,	_	12	punct	_	_
16	which	which	WDT	WDT	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	common	common	JJ	JJ	_	12	acl:relcl	_	_
19	to	to	TO	TO	_	23	case	_	_
20	all	all	DT	DT	_	23	det	_	_
21	three	three	CD	CD	_	23	nummod	_	_
22	NF-ATc	nf-atc	NN	NN	_	23	compound	_	_
23	isoforms	isoform	NNS	NNS	_	18	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	NF-ATc/C	nf-atc/c	NN	NN	_	26	nsubj	_	_
26	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
27	a	a	DT	DT	_	30	det	_	_
28	second	second	JJ	JJ	_	30	amod	_	_
29	trans-activation	trans-activation	NN	NN	_	30	compound	_	_
30	domain	domain	NN	NN	_	26	dobj	_	_
31	,	,	,	,	_	30	punct	_	_
32	TAD-B	tad-b	NN	NN	_	30	appos	_	_
33	,	,	,	,	_	26	punct	_	_
34	in	in	IN	IN	_	37	case	_	_
35	its	its	PRP$	PRP$	_	37	nmod:poss	_	_
36	C-terminal	c-terminal	JJ	JJ	_	37	amod	_	_
37	peptide	peptide	NN	NN	_	26	nmod	_	_
38	.	.	.	.	_	2	punct	_	_

1	Various	various	JJ	JJ	_	2	amod	_	_
2	stimuli	stimulus	NNS	NNS	_	13	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	T	t	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	that	that	WDT	WDT	_	7	nsubj	_	_
7	induce	induce	VBP	VBP	_	5	acl:relcl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	TAD-A	tad-a	NN	NN	_	9	nmod	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	enhance	enhance	VBP	VBP	_	0	root	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	TAD-B	tad-b	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	13	punct	_	_
19	but	but	CC	CC	_	13	cc	_	_
20	,	,	,	,	_	13	punct	_	_
21	unlike	unlike	IN	IN	_	22	case	_	_
22	TAD-A	tad-a	NN	NN	_	25	nmod	_	_
23	,	,	,	,	_	25	punct	_	_
24	TAD-B	tad-b	NN	NN	_	25	nsubj	_	_
25	remains	remain	VBZ	VBZ	_	13	conj	_	_
26	unphosphorylated	unphosphorylated	JJ	JJ	_	25	xcomp	_	_
27	by	by	IN	IN	_	28	case	_	_
28	protein	protein	NN	NN	_	26	nmod	_	_
29	from	from	IN	IN	_	34	case	_	_
30	12-O-tetradecanoyl	12-o-tetradecanoyl	NN	NN	_	34	compound	_	_
31	12-phorbol	12-phorbol	NN	NN	_	34	compound	_	_
32	13-acetate-stimulated	13-acetate-stimulated	JJ	JJ	_	34	amod	_	_
33	T	t	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	28	nmod	_	_
35	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	shorter	shorter	JJR	JJR	_	4	amod	_	_
3	C-terminal	c-terminal	JJ	JJ	_	4	amod	_	_
4	peptide	peptide	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	isoform	isoform	NN	NN	_	7	compound	_	_
7	NF-ATc/B	nf-atc/b	NN	NN	_	4	nmod	_	_
8	exerts	exert	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	12	det	_	_
10	suppressive	suppressive	JJ	JJ	_	12	amod	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	8	dobj	_	_
13	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	properties	property	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	NF-ATc/B	nf-atc/b	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	-C	-c	NN	NN	_	4	conj	_	_
7	might	might	MD	MD	_	10	aux	_	_
8	be	be	VB	VB	_	10	cop	_	_
9	of	of	IN	IN	_	10	case	_	_
10	importance	importance	NN	NN	_	0	root	_	_
11	for	for	IN	IN	_	13	case	_	_
12	gene	gene	NN	NN	_	13	compound	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	naive	naive	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	in	in	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	25	nmod	_	_
20	NF-ATc/B	nf-atc/b	NN	NN	_	25	nsubjpass	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	-C	-c	NN	NN	_	20	conj	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	predominantly	predominantly	RB	RB	_	25	advmod	_	_
25	synthesized	synthesize	VBN	VBN	_	17	acl:relcl	_	_
26	.	.	.	.	_	10	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	lymphocyte	lymphocyte	NN	NN	_	6	compound	_	_
6	development	development	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	function	function	NN	NN	_	6	conj	_	_
9	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	development	development	NN	NN	_	9	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	function	function	NN	NN	_	2	conj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	tightly	tightly	RB	RB	_	9	advmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	signal	signal	NN	NN	_	14	compound	_	_
13	transduction	transduction	NN	NN	_	14	compound	_	_
14	pathways	pathway	NNS	NNS	_	9	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	include	include	VBP	VBP	_	14	acl:relcl	_	_
17	specific	specific	JJ	JJ	_	19	amod	_	_
18	cell-surface	cell-surface	JJ	JJ	_	19	amod	_	_
19	receptors	receptor	NNS	NNS	_	16	dobj	_	_
20	,	,	,	,	_	19	punct	_	_
21	intracellular	intracellular	JJ	JJ	_	23	amod	_	_
22	signaling	signal	VBG	VBG	_	23	amod	_	_
23	molecules	molecule	NNS	NNS	_	19	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	19	conj	_	_
29	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	2	case	_	_
2	1988	1988	CD	CD	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	several	several	JJ	JJ	_	5	amod	_	_
5	families	family	NNS	NNS	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	12	case	_	_
7	functionally	functionally	RB	RB	_	8	advmod	_	_
8	important	important	JJ	JJ	_	12	amod	_	_
9	T	t	NN	NN	_	12	compound	_	_
10	cell	cell	NN	NN	_	12	compound	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	5	nmod	_	_
13	have	have	VBP	VBP	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	identified	identify	VBN	VBN	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	These	these	DT	DT	_	2	nsubj	_	_
2	include	include	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	dep	_	_
4	Ikaros	ikaros	NN	NN	_	2	dobj	_	_
5	,	,	,	,	_	4	punct	_	_
6	LKLF	lklf	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	GATA3	gata3	NN	NN	_	11	compound	_	_
10	zinc-finger	zinc-finger	JJ	JJ	_	11	amod	_	_
11	proteins	protein	NNS	NNS	_	4	conj	_	_
12	;	;	:	:	_	4	punct	_	_
13	the	the	DT	DT	_	14	dep	_	_
14	Ets	ets	NN	NN	_	4	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	CREB/ATF	creb/atf	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	NF-kappa	nf-kappa	NN	NN	_	22	compound	_	_
20	B/Rel/NFAT	b/rel/nfat	NN	NN	_	22	compound	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factors	factor	NNS	NNS	_	14	conj	_	_
23	;	;	:	:	_	4	punct	_	_
24	the	the	DT	DT	_	26	det	_	_
25	Stat	stat	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	4	conj	_	_
27	;	;	:	:	_	4	punct	_	_
28	and	and	CC	CC	_	4	cc	_	_
29	HMG	hmg	NN	NN	_	32	compound	_	_
30	box	box	NN	NN	_	32	compound	_	_
31	transcription	transcription	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	4	conj	_	_
33	such	such	JJ	JJ	_	35	case	_	_
34	as	as	IN	IN	_	33	mwe	_	_
35	LEF1	lef1	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	TCF1	tcf1	NN	NN	_	35	conj	_	_
38	,	,	,	,	_	35	punct	_	_
39	and	and	CC	CC	_	35	cc	_	_
40	Sox4	sox4	NN	NN	_	35	conj	_	_
41	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	summarize	summarize	VBP	VBP	_	0	root	_	_
7	our	we	PRP$	PRP$	_	9	nmod:poss	_	_
8	current	current	JJ	JJ	_	9	amod	_	_
9	understanding	understanding	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	transcriptional	transcriptional	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	13	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	function	function	NN	NN	_	17	conj	_	_
20	with	with	IN	IN	_	22	case	_	_
21	particular	particular	JJ	JJ	_	22	amod	_	_
22	emphasis	emphasis	NN	NN	_	6	nmod	_	_
23	on	on	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	results	result	NNS	NNS	_	22	nmod	_	_
26	of	of	IN	IN	_	32	case	_	_
27	recent	recent	JJ	JJ	_	32	amod	_	_
28	gene	gene	NN	NN	_	29	dep	_	_
29	targeting	targeting	NN	NN	_	27	dep	_	_
30	and	and	CC	CC	_	27	cc	_	_
31	transgenic	transgenic	JJ	JJ	_	27	conj	_	_
32	experiments	experiment	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	22	nmod	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	increasing	increase	VBG	VBG	_	2	acl	_	_
5	our	we	PRP$	PRP$	_	6	nmod:poss	_	_
6	understanding	understanding	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	pathways	pathway	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	regulate	regulate	VBP	VBP	_	10	acl:relcl	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	function	function	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	22	punct	_	_
19	these	these	DT	DT	_	20	det	_	_
20	results	result	NNS	NNS	_	22	nsubj	_	_
21	have	have	VBP	VBP	_	22	aux	_	_
22	suggested	suggest	VBN	VBN	_	0	root	_	_
23	novel	novel	JJ	JJ	_	24	amod	_	_
24	targets	target	NNS	NNS	_	22	dobj	_	_
25	for	for	IN	IN	_	29	case	_	_
26	genetic	genetic	JJ	JJ	_	29	amod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	pharmacological	pharmacological	JJ	JJ	_	26	conj	_	_
29	manipulation	manipulation	NN	NN	_	22	nmod	_	_
30	of	of	IN	IN	_	33	case	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	immunity	immunity	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	22	punct	_	_

1	Development	development	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	maturation	maturation	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	secondary	secondary	JJ	JJ	_	7	amod	_	_
6	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	1	nmod	_	_
8	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	secondary	secondary	JJ	JJ	_	4	amod	_	_
3	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
4	tissues	tissue	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	aux	_	_
6	located	located	JJ	JJ	_	0	root	_	_
7	at	at	IN	IN	_	9	case	_	_
8	strategic	strategic	JJ	JJ	_	9	amod	_	_
9	sites	site	NNS	NNS	_	6	nmod	_	_
10	where	where	WRB	WRB	_	16	advmod	_	_
11	foreign	foreign	JJ	JJ	_	12	amod	_	_
12	antigens	antigen	NNS	NNS	_	16	nsubjpass	_	_
13	can	can	MD	MD	_	16	aux	_	_
14	be	be	VB	VB	_	16	auxpass	_	_
15	efficiently	efficiently	RB	RB	_	16	advmod	_	_
16	brought	bring	VBN	VBN	_	9	acl:relcl	_	_
17	together	together	RB	RB	_	16	advmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	immune	immune	JJ	JJ	_	21	amod	_	_
20	system	system	NN	NN	_	21	nmod:npmod	_	_
21	regulatory	regulatory	JJ	JJ	_	16	advcl	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	effector	effector	NN	NN	_	21	conj	_	_
24	cells	cell	NNS	NNS	_	21	dep	_	_
25	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	organized	organize	VBN	VBN	_	3	amod	_	_
3	structure	structure	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	8	case	_	_
5	the	the	DT	DT	_	8	det	_	_
6	secondary	secondary	JJ	JJ	_	8	amod	_	_
7	lymphoid	lymphoid	JJ	JJ	_	8	amod	_	_
8	tissues	tissue	NNS	NNS	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	thought	think	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	enhance	enhance	VB	VB	_	10	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	sensitivity	sensitivity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	antigen	antigen	NN	NN	_	17	compound	_	_
17	recognition	recognition	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	support	support	VB	VB	_	12	conj	_	_
21	proper	proper	JJ	JJ	_	22	amod	_	_
22	regulation	regulation	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	maturation	maturation	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	antigen-responsive	antigen-responsive	JJ	JJ	_	32	amod	_	_
31	lymphoid	lymphoid	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	10	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	a	a	DT	DT	_	4	det	_	_
3	substantial	substantial	JJ	JJ	_	4	amod	_	_
4	amount	amount	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	42	advcl	_	_
7	about	about	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	elements	element	NNS	NNS	_	6	nmod	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	compose	compose	VBP	VBP	_	10	acl:relcl	_	_
13	the	the	DT	DT	_	17	det	_	_
14	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	nonlymphoid	nonlymphoid	JJ	JJ	_	14	conj	_	_
17	components	component	NNS	NNS	_	12	dobj	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	secondary	secondary	JJ	JJ	_	22	amod	_	_
21	lymphoid	lymphoid	JJ	JJ	_	22	amod	_	_
22	tissues	tissue	NNS	NNS	_	17	nmod	_	_
23	,	,	,	,	_	42	punct	_	_
24	information	information	NN	NN	_	42	nsubj	_	_
25	concerning	concern	VBG	VBG	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	signals	signal	NNS	NNS	_	24	nmod	_	_
28	that	that	WDT	WDT	_	29	nsubj	_	_
29	control	control	VBP	VBP	_	27	acl:relcl	_	_
30	the	the	DT	DT	_	31	det	_	_
31	development	development	NN	NN	_	29	dobj	_	_
32	of	of	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	tissues	tissue	NNS	NNS	_	31	nmod	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	that	that	WDT	WDT	_	37	nsubj	_	_
37	maintain	maintain	VBP	VBP	_	29	conj	_	_
38	the	the	DT	DT	_	41	det	_	_
39	organized	organize	VBN	VBN	_	41	amod	_	_
40	tissue	tissue	NN	NN	_	41	compound	_	_
41	microenvironment	microenvironment	NN	NN	_	37	dobj	_	_
42	remain	remain	VBP	VBP	_	0	root	_	_
43	undefined	undefined	JJ	JJ	_	42	xcomp	_	_
44	.	.	.	.	_	42	punct	_	_

1	Studies	study	NNS	NNS	_	8	nsubj	_	_
2	over	over	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	past	past	JJ	JJ	_	6	amod	_	_
5	few	few	JJ	JJ	_	6	amod	_	_
6	years	year	NNS	NNS	_	1	nmod	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	lymphotoxin	lymphotoxin	NN	NN	_	8	dobj	_	_
10	as	as	IN	IN	_	14	case	_	_
11	a	a	DT	DT	_	14	det	_	_
12	critical	critical	JJ	JJ	_	14	amod	_	_
13	signaling	signal	VBG	VBG	_	14	amod	_	_
14	molecule	molecule	NN	NN	_	8	nmod	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	only	only	RB	RB	_	19	cc:preconj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	organogenesis	organogenesis	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	secondary	secondary	JJ	JJ	_	23	amod	_	_
22	lymphoid	lymphoid	JJ	JJ	_	23	amod	_	_
23	tissues	tissue	NNS	NNS	_	19	nmod	_	_
24	but	but	CC	CC	_	19	cc	_	_
25	for	for	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	maintenance	maintenance	NN	NN	_	19	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	aspects	aspect	NNS	NNS	_	27	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	their	they	PRP$	PRP$	_	32	nmod:poss	_	_
32	microarchitecture	microarchitecture	NN	NN	_	29	nmod	_	_
33	as	as	RB	RB	_	27	advmod	_	_
34	well	well	RB	RB	_	33	mwe	_	_
35	.	.	.	.	_	8	punct	_	_

1	Additional	additional	JJ	JJ	_	3	amod	_	_
2	signaling	signal	VBG	VBG	_	3	amod	_	_
3	molecules	molecule	NNS	NNS	_	16	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	contribute	contribute	VBP	VBP	_	3	acl:relcl	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	formation	formation	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	lymphoid	lymphoid	JJ	JJ	_	13	amod	_	_
12	tissue	tissue	NN	NN	_	13	compound	_	_
13	structure	structure	NN	NN	_	8	nmod	_	_
14	are	be	VBP	VBP	_	16	aux	_	_
15	being	be	VBG	VBG	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	0	root	_	_
17	at	at	IN	IN	_	20	case	_	_
18	an	a	DT	DT	_	20	det	_	_
19	accelerating	accelerate	VBG	VBG	_	20	amod	_	_
20	pace	pace	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	Analyses	analysis	NNS	NNS	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	mouse	mouse	NN	NN	_	4	compound	_	_
4	strains	strain	NNS	NNS	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	congenital	congenital	JJ	JJ	_	7	amod	_	_
7	defects	defect	NNS	NNS	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	different	different	JJ	JJ	_	10	amod	_	_
10	aspects	aspect	NNS	NNS	_	1	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	secondary	secondary	JJ	JJ	_	15	amod	_	_
13	lymphoid	lymphoid	JJ	JJ	_	15	amod	_	_
14	tissue	tissue	NN	NN	_	15	compound	_	_
15	development	development	NN	NN	_	10	nmod	_	_
16	are	be	VBP	VBP	_	17	aux	_	_
17	beginning	begin	VBG	VBG	_	0	root	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	clarify	clarify	VB	VB	_	17	xcomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	role	role	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	tissues	tissue	NNS	NNS	_	21	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	immune	immune	JJ	JJ	_	27	amod	_	_
27	responses	response	NNS	NNS	_	21	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	host	host	NN	NN	_	30	compound	_	_
30	defense	defense	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	focuses	focus	VBZ	VBZ	_	0	root	_	_
4	on	on	IN	IN	_	5	case	_	_
5	studies	study	NNS	NNS	_	3	nmod	_	_
6	defining	define	VBG	VBG	_	5	acl	_	_
7	recently	recently	RB	RB	_	8	advmod	_	_
8	identified	identify	VBN	VBN	_	10	amod	_	_
9	crucial	crucial	JJ	JJ	_	10	amod	_	_
10	signals	signal	NNS	NNS	_	6	dobj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	biogenesis	biogenesis	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	secondary	secondary	JJ	JJ	_	17	amod	_	_
16	lymphoid	lymphoid	JJ	JJ	_	17	amod	_	_
17	organs	organ	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	maintenance	maintenance	NN	NN	_	13	conj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	proper	proper	JJ	JJ	_	25	amod	_	_
25	microarchitecture	microarchitecture	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	discusses	discuss	VBZ	VBZ	_	0	root	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	insights	insight	NNS	NNS	_	3	dobj	_	_
6	into	into	IN	IN	_	13	mark	_	_
7	how	how	WRB	WRB	_	13	advmod	_	_
8	the	the	DT	DT	_	9	det	_	_
9	structure	structure	NN	NN	_	13	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	tissues	tissue	NNS	NNS	_	9	nmod	_	_
13	supports	support	VBZ	VBZ	_	5	acl	_	_
14	effective	effective	JJ	JJ	_	16	amod	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	responses	response	NNS	NNS	_	13	dobj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Selection	selection	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	repertoire	repertoire	NN	NN	_	1	nmod	_	_
7	.	.	.	.	_	1	punct	_	_

1	Advances	advance	NNS	NNS	_	6	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	technology	technology	NN	NN	_	1	nmod	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	allowed	allow	VBN	VBN	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	manipulation	manipulation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	molecular	molecular	JJ	JJ	_	11	amod	_	_
11	interactions	interaction	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	shape	shape	VBP	VBP	_	11	acl:relcl	_	_
14	the	the	DT	DT	_	17	det	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	repertoire	repertoire	NN	NN	_	13	dobj	_	_
18	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	2	mark	_	_
2	recognized	recognize	VBN	VBN	_	22	advcl	_	_
3	as	as	IN	IN	_	5	case	_	_
4	fundamental	fundamental	JJ	JJ	_	5	amod	_	_
5	aspects	aspect	NNS	NNS	_	2	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	lymphocyte	lymphocyte	NN	NN	_	9	compound	_	_
9	development	development	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	22	punct	_	_
11	only	only	RB	RB	_	12	advmod	_	_
12	recently	recently	RB	RB	_	22	advmod	_	_
13	have	have	VBP	VBP	_	22	aux	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanisms	mechanism	NNS	NNS	_	22	nsubjpass	_	_
16	governing	govern	VBG	VBG	_	15	acl	_	_
17	positive	positive	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	negative	negative	JJ	JJ	_	17	conj	_	_
20	selection	selection	NN	NN	_	16	dobj	_	_
21	been	be	VBN	VBN	_	22	auxpass	_	_
22	examined	examine	VBN	VBN	_	0	root	_	_
23	at	at	IN	IN	_	26	case	_	_
24	a	a	DT	DT	_	26	det	_	_
25	molecular	molecular	JJ	JJ	_	26	amod	_	_
26	level	level	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	22	punct	_	_

1	Positive	positive	JJ	JJ	_	2	amod	_	_
2	selection	selection	NN	NN	_	3	nsubj	_	_
3	refers	refer	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	process	process	NN	NN	_	3	nmod	_	_
8	of	of	IN	IN	_	9	mark	_	_
9	rescuing	rescue	VBG	VBG	_	7	acl	_	_
10	MHC-restricted	mhc-restricted	JJ	JJ	_	11	amod	_	_
11	thymocytes	thymocyte	NNS	NNS	_	9	dobj	_	_
12	from	from	IN	IN	_	15	case	_	_
13	programmed	program	VBN	VBN	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	death	death	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Negative	negative	JJ	JJ	_	2	amod	_	_
2	selection	selection	NN	NN	_	3	nsubj	_	_
3	refers	refer	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	deletion	deletion	NN	NN	_	3	nmod	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	inactivation	inactivation	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	potentially	potentially	RB	RB	_	12	advmod	_	_
11	autoreactive	autoreactive	JJ	JJ	_	12	amod	_	_
12	thymocytes	thymocyte	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	review	review	NN	NN	_	3	nsubj	_	_
3	focuses	focus	VBZ	VBZ	_	0	root	_	_
4	on	on	IN	IN	_	5	case	_	_
5	interactions	interaction	NNS	NNS	_	3	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	thymocyte	thymocyte	NN	NN	_	8	compound	_	_
8	maturation	maturation	NN	NN	_	5	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	define	define	VBP	VBP	_	5	acl:relcl	_	_
11	the	the	DT	DT	_	14	det	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	repertoire	repertoire	NN	NN	_	10	dobj	_	_
15	,	,	,	,	_	10	punct	_	_
16	with	with	IN	IN	_	18	case	_	_
17	an	a	DT	DT	_	18	det	_	_
18	emphasis	emphasis	NN	NN	_	10	nmod	_	_
19	placed	place	VBN	VBN	_	18	acl	_	_
20	on	on	IN	IN	_	22	case	_	_
21	current	current	JJ	JJ	_	22	amod	_	_
22	literature	literature	NN	NN	_	19	nmod	_	_
23	within	within	IN	IN	_	25	case	_	_
24	this	this	DT	DT	_	25	det	_	_
25	field	field	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Phorbol	phorbol	NN	NN	_	5	compound	_	_
2	ester-induced	ester-induced	JJ	JJ	_	5	amod	_	_
3	mononuclear	mononuclear	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	differentiation	differentiation	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	blocked	block	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	17	case	_	_
9	the	the	DT	DT	_	17	det	_	_
10	mitogen-activated	mitogen-activated	JJ	JJ	_	13	amod	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MEK	mek	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	inhibitor	inhibitor	NN	NN	_	7	nmod	_	_
18	PD98059	pd98059	NN	NN	_	17	dep	_	_
19	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	purpose	purpose	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	evaluate	evaluate	VB	VB	_	6	xcomp	_	_
9	whether	whether	IN	IN	_	19	mark	_	_
10	the	the	DT	DT	_	18	det	_	_
11	mitogen-activated	mitogen-activated	JJ	JJ	_	13	amod	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	kinase	kinase	NN	NN	_	18	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	MAPK	mapk	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	signaling	signaling	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	19	nsubj	_	_
19	contributes	contribute	VBZ	VBZ	_	8	ccomp	_	_
20	to	to	TO	TO	_	27	case	_	_
21	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	27	compound	_	_
22	(	(	-LRB-	-LRB-	_	27	punct	_	_
23	TPA	tpa	NN	NN	_	27	compound	_	_
24	)	)	-RRB-	-RRB-	_	27	punct	_	_
25	-induced	-induced	JJ	JJ	_	27	amod	_	_
26	mononuclear	mononuclear	JJ	JJ	_	27	amod	_	_
27	differentiation	differentiation	NN	NN	_	19	nmod	_	_
28	in	in	IN	IN	_	34	case	_	_
29	the	the	DT	DT	_	34	det	_	_
30	human	human	JJ	JJ	_	34	amod	_	_
31	myeloblastic	myeloblastic	JJ	JJ	_	34	amod	_	_
32	leukemia	leukemia	NN	NN	_	34	compound	_	_
33	ML-1	ml-1	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	Upon	upon	IN	IN	_	3	case	_	_
2	TPA	tpa	NN	NN	_	3	compound	_	_
3	treatment	treatment	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	ERK1	erk1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	ERK2	erk2	NN	NN	_	8	conj	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	increased	increase	VBD	VBD	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	with	with	IN	IN	_	16	case	_	_
15	maximal	maximal	JJ	JJ	_	16	amod	_	_
16	induction	induction	NN	NN	_	12	nmod	_	_
17	between	between	IN	IN	_	21	case	_	_
18	1	1	CD	CD	_	21	nummod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	3	3	CD	CD	_	18	conj	_	_
21	h	h	NN	NN	_	16	nmod	_	_
22	,	,	,	,	_	12	punct	_	_
23	while	while	IN	IN	_	27	mark	_	_
24	ERK2	erk2	NN	NN	_	26	compound	_	_
25	protein	protein	NN	NN	_	26	compound	_	_
26	levels	level	NNS	NNS	_	27	nsubj	_	_
27	remained	remain	VBD	VBD	_	12	advcl	_	_
28	constant	constant	JJ	JJ	_	27	xcomp	_	_
29	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	activity	activity	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	JNK1	jnk1	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	8	auxpass	_	_
6	also	also	RB	RB	_	8	advmod	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	with	with	IN	IN	_	14	mark	_	_
11	JNK1	jnk1	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	levels	level	NNS	NNS	_	14	nsubj	_	_
14	increasing	increase	VBG	VBG	_	8	advcl	_	_
15	moderately	moderately	RB	RB	_	14	advmod	_	_
16	during	during	IN	IN	_	17	case	_	_
17	exposure	exposure	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	TPA	tpa	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	Treatment	treatment	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	cells	cell	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	PD98059	pd98059	NN	NN	_	1	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	a	a	DT	DT	_	9	det	_	_
8	specific	specific	JJ	JJ	_	9	amod	_	_
9	inhibitor	inhibitor	NN	NN	_	5	appos	_	_
10	of	of	IN	IN	_	14	case	_	_
11	mitogen-activated	mitogen-activated	JJ	JJ	_	14	amod	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	MEK	mek	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	19	punct	_	_
19	inhibited	inhibit	VBD	VBD	_	0	root	_	_
20	TPA-induced	tpa-induced	JJ	JJ	_	22	amod	_	_
21	ERK2	erk2	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	19	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PD98059	pd98059	NN	NN	_	5	nsubj	_	_
4	completely	completely	RB	RB	_	5	advmod	_	_
5	blocked	block	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	TPA-induced	tpa-induced	JJ	JJ	_	8	amod	_	_
8	differentiation	differentiation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	ML-1	ml-1	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	as	as	IN	IN	_	14	mark	_	_
14	assessed	assess	VBN	VBN	_	5	advcl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	number	number	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	features	feature	NNS	NNS	_	17	nmod	_	_
20	associated	associate	VBN	VBN	_	19	acl	_	_
21	with	with	IN	IN	_	23	case	_	_
22	mononuclear	mononuclear	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	including	include	VBG	VBG	_	25	case	_	_
25	changes	change	NNS	NNS	_	23	nmod	_	_
26	in	in	IN	IN	_	27	case	_	_
27	morphology	morphology	NN	NN	_	25	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	nonspecific	nonspecific	JJ	JJ	_	31	amod	_	_
30	esterase	esterase	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	27	conj	_	_
32	,	,	,	,	_	27	punct	_	_
33	phagocytic	phagocytic	JJ	JJ	_	34	amod	_	_
34	ability	ability	NN	NN	_	27	conj	_	_
35	,	,	,	,	_	27	punct	_	_
36	NADPH	nadph	NN	NN	_	38	compound	_	_
37	oxidase	oxidase	NN	NN	_	38	compound	_	_
38	activity	activity	NN	NN	_	27	conj	_	_
39	,	,	,	,	_	27	punct	_	_
40	mitochondrial	mitochondrial	JJ	JJ	_	41	amod	_	_
41	respiration	respiration	NN	NN	_	27	conj	_	_
42	,	,	,	,	_	27	punct	_	_
43	and	and	CC	CC	_	27	cc	_	_
44	c-jun	c-jun	NN	NN	_	46	compound	_	_
45	mRNA	mrna	NN	NN	_	46	compound	_	_
46	inducibility	inducibility	NN	NN	_	27	conj	_	_
47	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	activation	activation	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	MEK/ERK	mek/erk	NN	NN	_	9	compound	_	_
8	signaling	signaling	NN	NN	_	9	compound	_	_
9	pathway	pathway	NN	NN	_	4	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	necessary	necessary	JJ	JJ	_	2	ccomp	_	_
12	for	for	IN	IN	_	16	case	_	_
13	TPA-induced	tpa-induced	JJ	JJ	_	16	amod	_	_
14	mononuclear	mononuclear	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	differentiation	differentiation	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	2	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	functions	function	NNS	NNS	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	clinical	clinical	JJ	JJ	_	5	amod	_	_
5	parameters	parameter	NNS	NNS	_	2	appos	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	hormone	hormone	NN	NN	_	9	compound	_	_
8	receptor	receptor	NN	NN	_	9	compound	_	_
9	status	status	NN	NN	_	5	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	breast	breast	NN	NN	_	13	compound	_	_
12	cancer	cancer	NN	NN	_	13	compound	_	_
13	patients	patient	NNS	NNS	_	5	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	carried	carry	VBN	VBN	_	0	root	_	_
4	out	out	RP	RP	_	3	dep	_	_
5	a	a	DT	DT	_	7	det	_	_
6	detailed	detailed	JJ	JJ	_	7	amod	_	_
7	analysis	analysis	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	cellular	cellular	JJ	JJ	_	12	amod	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	functions	function	NNS	NNS	_	7	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	breast	breast	NN	NN	_	16	compound	_	_
15	cancer	cancer	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	12	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	comparison	comparison	NN	NN	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	healthy	healthy	JJ	JJ	_	21	amod	_	_
21	controls	control	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	possible	possible	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	10	nsubj	_	_
4	between	between	IN	IN	_	8	case	_	_
5	immune	immune	JJ	JJ	_	8	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	clinical	clinical	JJ	JJ	_	5	conj	_	_
8	parameters	parameter	NNS	NNS	_	3	nmod	_	_
9	was	be	VBD	VBD	_	10	dep	_	_
10	analysed	analyse	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	15	case	_	_
12	50	50	CD	CD	_	15	nummod	_	_
13	breast	breast	NN	NN	_	15	compound	_	_
14	cancer	cancer	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	parameters	parameter	NNS	NNS	_	19	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	natural	natural	JJ	JJ	_	6	amod	_	_
5	killer	killer	NN	NN	_	6	compound	_	_
6	cell	cell	NN	NN	_	2	appos	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	lymphocyte	lymphocyte	NN	NN	_	10	compound	_	_
10	functions	function	NNS	NNS	_	6	conj	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	numbers	number	NNS	NNS	_	6	conj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	circulating	circulate	VBG	VBG	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	analysed	analyse	VBN	VBN	_	0	root	_	_
20	against	against	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	clinical	clinical	JJ	JJ	_	23	amod	_	_
23	parameters	parameter	NNS	NNS	_	19	nmod	_	_
24	comprising	comprise	VBG	VBG	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	tumour	tumour	NN	NN	_	27	compound	_	_
27	burden	burden	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	27	punct	_	_
29	the	the	DT	DT	_	30	det	_	_
30	stage	stage	NN	NN	_	27	conj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	disease	disease	NN	NN	_	30	nmod	_	_
34	and	and	CC	CC	_	27	cc	_	_
35	the	the	DT	DT	_	36	det	_	_
36	expression	expression	NN	NN	_	27	conj	_	_
37	of	of	IN	IN	_	39	case	_	_
38	hormone	hormone	NN	NN	_	39	compound	_	_
39	receptors	receptor	NNS	NNS	_	36	nmod	_	_
40	on	on	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	tumour	tumour	NN	NN	_	36	nmod	_	_
43	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	4	mark	_	_
2	order	order	NN	NN	_	1	mwe	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	analyse	analyse	VB	VB	_	14	advcl	_	_
5	the	the	DT	DT	_	8	det	_	_
6	immune	immune	JJ	JJ	_	8	amod	_	_
7	function	function	NN	NN	_	8	compound	_	_
8	data	datum	NNS	NNS	_	4	dobj	_	_
9	effectively	effectively	RB	RB	_	4	advmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	low	low	JJ	JJ	_	12	amod	_	_
12	responders	responder	NNS	NNS	_	14	nsubjpass	_	_
13	were	be	VBD	VBD	_	14	auxpass	_	_
14	identified	identify	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	18	case	_	_
16	stringent	stringent	JJ	JJ	_	18	amod	_	_
17	cut-off	cut-off	JJ	JJ	_	18	amod	_	_
18	values	value	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	14	punct	_	_

1	Considerably	considerably	RB	RB	_	2	advmod	_	_
2	higher	higher	JJR	JJR	_	3	amod	_	_
3	proportions	proportion	NNS	NNS	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	low	low	JJ	JJ	_	6	amod	_	_
6	responders	responder	NNS	NNS	_	3	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	among	among	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	patient	patient	NN	NN	_	12	compound	_	_
12	population	population	NN	NN	_	8	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Elevated	elevated	JJ	JJ	_	2	amod	_	_
2	numbers	number	NNS	NNS	_	10	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	circulating	circulate	VBG	VBG	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	CD3-directed	cd3-directed	JJ	JJ	_	9	amod	_	_
9	cytolysis	cytolysis	NN	NN	_	6	conj	_	_
10	correlated	correlate	VBD	VBD	_	0	root	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	oestrogen	oestrogen	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	nmod	_	_
17	independently	independently	RB	RB	_	16	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	clinical/histological	clinical/histological	JJ	JJ	_	21	amod	_	_
21	parameters	parameter	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	UV-induced	uv-induced	JJ	JJ	_	4	amod	_	_
2	CYP1A1	cyp1a1	NN	NN	_	4	compound	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	9	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	mediated	mediate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	tryptophan	tryptophan	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Induction	induction	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	8	case	_	_
3	cytochrome	cytochrome	NN	NN	_	4	compound	_	_
4	P-4501A1	p-4501a1	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	CYP1A1	cyp1a1	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	activity	activity	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	UV	uv	NN	NN	_	1	nmod	_	_
11	has	have	VBZ	VBZ	_	13	aux	_	_
12	been	be	VBN	VBN	_	13	auxpass	_	_
13	observed	observe	VBN	VBN	_	0	root	_	_
14	earlier	earlier	RBR	RBR	_	13	advcl	_	_
15	in	in	IN	IN	_	17	case	_	_
16	animal	animal	NN	NN	_	17	compound	_	_
17	studies	study	NNS	NNS	_	14	nmod	_	_
18	via	via	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	mechanism	mechanism	NN	NN	_	13	nmod	_	_
21	that	that	WDT	WDT	_	26	nsubjpass	_	_
22	has	have	VBZ	VBZ	_	26	aux	_	_
23	not	not	RB	RB	_	26	neg	_	_
24	yet	yet	RB	RB	_	26	advmod	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	resolved	resolve	VBN	VBN	_	20	acl:relcl	_	_
27	.	.	.	.	_	13	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	data	datum	NNS	NNS	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	indicated	indicate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	22	mark	_	_
7	formylated	formylate	VBN	VBN	_	8	amod	_	_
8	indolocarbazoles	indolocarbazole	NNS	NNS	_	22	nsubj	_	_
9	which	which	WDT	WDT	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	formed	form	VBN	VBN	_	8	acl:relcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	UV	uv	NN	NN	_	14	compound	_	_
14	irradiation	irradiation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	tryptophan	tryptophan	NN	NN	_	17	compound	_	_
17	solutions	solution	NNS	NNS	_	14	nmod	_	_
18	are	be	VBP	VBP	_	22	cop	_	_
19	very	very	RB	RB	_	20	advmod	_	_
20	potent	potent	JJ	JJ	_	22	amod	_	_
21	Ah-receptor	ah-receptor	NN	NN	_	22	compound	_	_
22	agonists	agonist	NNS	NNS	_	5	ccomp	_	_
23	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	15	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	UV	uv	NN	NN	_	7	compound	_	_
7	light	light	NN	NN	_	4	nmod	_	_
8	on	on	IN	IN	_	10	case	_	_
9	cytochrome	cytochrome	NN	NN	_	10	compound	_	_
10	P4501A1	p4501a1	NN	NN	_	4	nmod	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	10	dep	_	_
13	,	,	,	,	_	15	punct	_	_
14	we	we	PRP	PRP	_	15	nsubj	_	_
15	studied	study	VBD	VBD	_	0	root	_	_
16	the	the	DT	DT	_	17	det	_	_
17	induction	induction	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	CYP1A1	cyp1a1	NN	NN	_	20	compound	_	_
20	mRNA	mrna	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	23	case	_	_
22	UV	uv	NN	NN	_	23	compound	_	_
23	irradiation	irradiation	NN	NN	_	15	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	cultured	culture	VBN	VBN	_	27	amod	_	_
26	human	human	JJ	JJ	_	27	amod	_	_
27	keratinocytes	keratinocyte	NNS	NNS	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	HaCaT	hacat	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	line	line	NN	NN	_	27	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	,	,	,	,	_	27	punct	_	_
34	primary	primary	JJ	JJ	_	37	amod	_	_
35	human	human	JJ	JJ	_	37	amod	_	_
36	blood	blood	NN	NN	_	37	compound	_	_
37	lymphocytes	lymphocyte	NNS	NNS	_	27	conj	_	_
38	and	and	CC	CC	_	27	cc	_	_
39	mouse	mouse	NN	NN	_	41	compound	_	_
40	Hepa-1	hepa-1	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	27	conj	_	_
42	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	cells	cell	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	exposed	expose	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	UV	uv	NN	NN	_	7	compound	_	_
7	light	light	NN	NN	_	4	nmod	_	_
8	delivered	deliver	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	bank	bank	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	17	case	_	_
13	6	6	CD	CD	_	17	nummod	_	_
14	Philips	philips	NN	NN	_	17	compound	_	_
15	TL20/12RS	tl20/12rs	NN	NN	_	17	compound	_	_
16	sun	sun	NN	NN	_	17	compound	_	_
17	lamps	lamp	NNS	NNS	_	11	nmod	_	_
18	emitting	emit	VBG	VBG	_	17	acl	_	_
19	primarily	primarily	RB	RB	_	18	advmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	UVB	uvb	NN	NN	_	23	compound	_	_
23	range	range	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	absence	absence	NN	NN	_	4	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	presence	presence	NN	NN	_	26	conj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	tryptophan	tryptophan	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	7	det	_	_
2	semiquantitative	semiquantitative	JJ	JJ	_	7	amod	_	_
3	reverse	reverse	NN	NN	_	7	compound	_	_
4	transcriptase-linked	transcriptase-linked	JJ	JJ	_	7	amod	_	_
5	polymerase	polymerase	NN	NN	_	7	compound	_	_
6	chain	chain	NN	NN	_	7	compound	_	_
7	reaction	reaction	NN	NN	_	12	nsubjpass	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RT-PCR	rt-pcr	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	used	use	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	14	case	_	_
14	analysis	analysis	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	gene	gene	NN	NN	_	17	compound	_	_
17	expression	expression	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	treated	treat	VBN	VBN	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	CYP1A1	cyp1a1	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	level	level	NN	NN	_	18	nsubj	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	UV	uv	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	tryptophan	tryptophan	NN	NN	_	14	nmod	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	higher	higher	JJR	JJR	_	3	ccomp	_	_
19	than	than	IN	IN	_	20	case	_	_
20	that	that	DT	DT	_	18	nmod	_	_
21	induced	induce	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	23	case	_	_
23	UV	uv	NN	NN	_	21	nmod	_	_
24	alone	alone	RB	RB	_	23	amod	_	_
25	in	in	IN	IN	_	28	case	_	_
26	both	both	CC	CC	_	28	cc:preconj	_	_
27	HaCaT	hacat	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	21	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	lymphocytes	lymphocyte	NNS	NNS	_	28	conj	_	_
31	after	after	IN	IN	_	33	case	_	_
32	3	3	CD	CD	_	33	nummod	_	_
33	h	h	NN	NN	_	21	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	incubation	incubation	NN	NN	_	37	compound	_	_
36	post-UV	post-uv	JJ	JJ	_	37	amod	_	_
37	irradiation	irradiation	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	find	find	VB	VB	_	31	advcl	_	_
3	out	out	RP	RP	_	2	dep	_	_
4	if	if	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	induction	induction	NN	NN	_	11	nsubjpass	_	_
7	by	by	IN	IN	_	9	case	_	_
8	UV	uv	NN	NN	_	9	compound	_	_
9	light	light	NN	NN	_	6	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	caused	cause	VBN	VBN	_	2	advcl	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	formation	formation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	an	a	DT	DT	_	19	det	_	_
17	Ah	ah	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	ligand	ligand	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	31	punct	_	_
21	Hepa-1	hepa-1	NN	NN	_	31	nsubjpass	_	_
22	wild-type	wild-type	JJ	JJ	_	21	amod	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	Ah	ah	NN	NN	_	29	compound	_	_
25	receptor	receptor	NN	NN	_	29	compound	_	_
26	deficient	deficient	JJ	JJ	_	29	amod	_	_
27	c12	c12	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	lines	line	NNS	NNS	_	21	conj	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	applied	apply	VBN	VBN	_	0	root	_	_
32	.	.	.	.	_	31	punct	_	_

1	Wild-type	wild-type	JJ	JJ	_	5	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	wt	wt	JJ	JJ	_	1	dep	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	cells	cell	NNS	NNS	_	7	nsubj	_	_
6	were	be	VBD	VBD	_	7	cop	_	_
7	inducible	inducible	JJ	JJ	_	0	root	_	_
8	either	either	CC	CC	_	12	cc:preconj	_	_
9	by	by	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	tryptophan	tryptophan	NN	NN	_	12	compound	_	_
12	photoproduct	photoproduct	NN	NN	_	7	nmod	_	_
13	6-formylindolo	6-formylindolo	JJ	JJ	_	19	amod	_	_
14	-LSB-	-lsb-	-LRB-	-LRB-	_	19	punct	_	_
15	3	3	CD	CD	_	19	nummod	_	_
16	,	,	,	,	_	19	punct	_	_
17	2-b	2-b	JJ	JJ	_	19	amod	_	_
18	-RSB-	-rsb-	-RRB-	-RRB-	_	19	punct	_	_
19	carbazole	carbazole	NN	NN	_	12	dep	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	FICZ	ficz	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	or	or	CC	CC	_	12	cc	_	_
24	by	by	IN	IN	_	25	case	_	_
25	UV-irradiation	uv-irradiation	NN	NN	_	12	conj	_	_
26	but	but	CC	CC	_	7	cc	_	_
27	very	very	RB	RB	_	28	advmod	_	_
28	low	low	JJ	JJ	_	31	amod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	undetectable	undetectable	JJ	JJ	_	28	conj	_	_
31	levels	level	NNS	NNS	_	33	nsubjpass	_	_
32	were	be	VBD	VBD	_	33	auxpass	_	_
33	observed	observe	VBN	VBN	_	7	conj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	the	the	DT	DT	_	37	det	_	_
36	c12	c12	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	33	nmod	_	_
38	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	nsubj	_	_
2	shows	show	VBZ	VBZ	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	induction	induction	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	gene	gene	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	FICZ	ficz	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	UV	uv	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	Ah	ah	NN	NN	_	16	nmod:npmod	_	_
15	receptor	receptor	NN	NN	_	16	nmod:npmod	_	_
16	dependent	dependent	JJ	JJ	_	2	ccomp	_	_
17	.	.	.	.	_	2	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	UV-induced	uv-induced	JJ	JJ	_	10	amod	_	_
8	CYP1A1	cyp1a1	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	15	nsubjpass	_	_
11	in	in	IN	IN	_	13	case	_	_
12	mammalian	mammalian	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	mediated	mediate	VBN	VBN	_	5	ccomp	_	_
16	by	by	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	Ah	ah	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	ligand	ligand	NN	NN	_	15	nmod	_	_
21	formed	form	VBN	VBN	_	20	acl	_	_
22	from	from	IN	IN	_	23	case	_	_
23	tryptophan	tryptophan	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	15	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	photoproducts	photoproduct	NNS	NNS	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	tryptophan	tryptophan	NN	NN	_	4	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	suggested	suggest	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	cop	_	_
11	mediators	mediator	NNS	NNS	_	8	xcomp	_	_
12	of	of	IN	IN	_	13	case	_	_
13	light	light	NN	NN	_	11	nmod	_	_
14	via	via	IN	IN	_	15	case	_	_
15	binding	binding	NN	NN	_	11	nmod	_	_
16	to	to	TO	TO	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	Ah	ah	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	8	cc	_	_
21	as	as	IN	IN	_	22	case	_	_
22	such	such	JJ	JJ	_	8	conj	_	_
23	also	also	RB	RB	_	25	advmod	_	_
24	could	could	MD	MD	_	25	aux	_	_
25	have	have	VB	VB	_	8	dep	_	_
26	a	a	DT	DT	_	27	det	_	_
27	role	role	NN	NN	_	25	dobj	_	_
28	in	in	IN	IN	_	31	case	_	_
29	light-regulated	light-regulated	JJ	JJ	_	31	amod	_	_
30	biological	biological	JJ	JJ	_	31	amod	_	_
31	rhythms	rhythm	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	Effects	effect	NNS	NNS	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	diesel	diesel	NN	NN	_	5	compound	_	_
4	organic	organic	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	1	nmod	_	_
6	on	on	IN	IN	_	8	case	_	_
7	chemokine	chemokine	NN	NN	_	8	compound	_	_
8	production	production	NN	NN	_	1	nmod	_	_
9	by	by	IN	IN	_	13	case	_	_
10	peripheral	peripheral	JJ	JJ	_	13	amod	_	_
11	blood	blood	NN	NN	_	13	compound	_	_
12	mononuclear	mononuclear	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	17	nsubjpass	_	_
2	:	:	:	:	_	17	punct	_	_
3	Polyaromatic	polyaromatic	NN	NN	_	4	compound	_	_
4	hydrocarbons	hydrocarbon	NNS	NNS	_	17	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	PAHs	pah	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	associated	associate	VBN	VBN	_	4	acl	_	_
9	with	with	IN	IN	_	12	case	_	_
10	diesel	diesel	NN	NN	_	12	compound	_	_
11	exhaust	exhaust	NN	NN	_	12	compound	_	_
12	particles	particle	NNS	NNS	_	8	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	DEPs	dep	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	found	find	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	atmospheric	atmospheric	JJ	JJ	_	22	amod	_	_
21	urban	urban	JJ	JJ	_	22	amod	_	_
22	pollution	pollution	NN	NN	_	17	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	compounds	compound	NNS	NNS	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	favor	favor	VB	VB	_	5	xcomp	_	_
8	IgE	ige	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	bronchial	bronchial	JJ	JJ	_	12	amod	_	_
12	hyperresponsiveness	hyperresponsiveness	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	airway	airway	NN	NN	_	16	compound	_	_
16	inflammation	inflammation	NN	NN	_	9	conj	_	_
17	.	.	.	.	_	5	punct	_	_

1	Chemokines	chemokine	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	group	group	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	7	case	_	_
6	chemotactic	chemotactic	JJ	JJ	_	7	amod	_	_
7	cytokines	cytokine	NNS	NNS	_	4	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	recruitment	recruitment	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effect	effect	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	DEP-PAHs	dep-pah	NNS	NNS	_	6	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	release	release	NN	NN	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-8	il-8	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	MCP-1	mcp-1	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	RANTES	rantes	NN	NN	_	16	conj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	PBMCs	pbmc	NNS	NNS	_	4	nmod	_	_
24	obtained	obtain	VBN	VBN	_	23	acl	_	_
25	from	from	IN	IN	_	27	case	_	_
26	healthy	healthy	JJ	JJ	_	27	amod	_	_
27	subjects	subject	NNS	NNS	_	24	nmod	_	_
28	.	.	.	.	_	4	punct	_	_

1	METHODS	method	NNS	NNS	_	8	dep	_	_
2	:	:	:	:	_	8	punct	_	_
3	Protein	protein	NN	NN	_	4	compound	_	_
4	production	production	NN	NN	_	8	nsubjpass	_	_
5	in	in	IN	IN	_	6	case	_	_
6	supernatants	supernatant	NNS	NNS	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	assessed	assess	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	ELISA	elisa	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	mRNA	mrna	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	16	nsubjpass	_	_
15	was	be	VBD	VBD	_	16	auxpass	_	_
16	evaluated	evaluate	VBN	VBN	_	8	conj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	semiquantitative	semiquantitative	JJ	JJ	_	19	amod	_	_
19	RT-PCR	rt-pcr	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	RESULTS	result	NNS	NNS	_	8	nsubj	_	_
2	:	:	:	:	_	8	punct	_	_
3	Secretion	secretion	NN	NN	_	8	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	IL-8	il-8	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	RANTES	rantes	NN	NN	_	5	conj	_	_
8	increased	increase	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	dose-dependent	dose-dependent	JJ	JJ	_	12	amod	_	_
12	manner	manner	NN	NN	_	8	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	increasing	increase	VBG	VBG	_	15	amod	_	_
15	concentrations	concentration	NNS	NNS	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	DEP-PAHs	dep-pah	NNS	NNS	_	15	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	range	range	NN	NN	_	15	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	0.5	0.5	CD	CD	_	22	nummod	_	_
22	ng	ng	NN	NN	_	19	appos	_	_
23	to	to	TO	TO	_	22	dep	_	_
24	50	50	CD	CD	_	25	nummod	_	_
25	ng/mL	ng/ml	NN	NN	_	22	dep	_	_
26	)	)	-RRB-	-RRB-	_	19	punct	_	_
27	.	.	.	.	_	8	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	contrary	contrary	NN	NN	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	release	release	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	MCP-1	mcp-1	NN	NN	_	6	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	significantly	significantly	RB	RB	_	11	advmod	_	_
11	inhibited	inhibit	VBN	VBN	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	also	also	RB	RB	_	11	advmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	dose-dependent	dose-dependent	JJ	JJ	_	17	amod	_	_
17	manner	manner	NN	NN	_	11	nmod	_	_
18	.	.	.	.	_	11	punct	_	_

1	Messenger	messenger	NN	NN	_	3	compound	_	_
2	RNA	rna	NN	NN	_	3	compound	_	_
3	production	production	NN	NN	_	12	nsubj	_	_
4	coding	code	VBG	VBG	_	3	amod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	IL-8	il-8	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	RANTES	rantes	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	MCP-1	mcp-1	NN	NN	_	6	conj	_	_
12	showed	show	VBD	VBD	_	0	root	_	_
13	parallel	parallel	JJ	JJ	_	14	amod	_	_
14	variations	variation	NNS	NNS	_	12	dobj	_	_
15	to	to	TO	TO	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	production	production	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	correspondent	correspondent	JJ	JJ	_	21	amod	_	_
21	proteins	protein	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	12	punct	_	_

1	Effects	effect	NNS	NNS	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	DEP-PAHs	dep-pah	NNS	NNS	_	1	nmod	_	_
4	became	become	VBD	VBD	_	0	root	_	_
5	significant	significant	JJ	JJ	_	4	xcomp	_	_
6	at	at	IN	IN	_	8	case	_	_
7	7	7	CD	CD	_	8	nummod	_	_
8	hours	hour	NNS	NNS	_	5	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	up	up	IN	IN	_	8	conj	_	_
11	to	to	TO	TO	_	15	case	_	_
12	48	48	CD	CD	_	15	nummod	_	_
13	hours	hour	NNS	NNS	_	15	compound	_	_
14	time	time	NN	NN	_	15	compound	_	_
15	culture	culture	NN	NN	_	10	nmod	_	_
16	for	for	IN	IN	_	17	case	_	_
17	MCP-1	mcp-1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	and	and	CC	CC	_	8	cc	_	_
20	up	up	IN	IN	_	8	conj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	24	24	CD	CD	_	25	nummod	_	_
23	hours	hour	NNS	NNS	_	25	compound	_	_
24	time	time	NN	NN	_	25	compound	_	_
25	culture	culture	NN	NN	_	20	nmod	_	_
26	for	for	IN	IN	_	27	case	_	_
27	IL-8	il-8	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	RANTES	rantes	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	supernatants	supernatant	NNS	NNS	_	14	nsubj	_	_
4	from	from	IN	IN	_	6	case	_	_
5	DEP-PAH-activated	dep-pah-activated	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	compared	compare	VBN	VBN	_	10	case	_	_
9	with	with	IN	IN	_	10	case	_	_
10	those	those	DT	DT	_	14	dep	_	_
11	of	of	IN	IN	_	12	case	_	_
12	controls	control	NNS	NNS	_	10	nmod	_	_
13	,	,	,	,	_	10	punct	_	_
14	exhibited	exhibit	VBD	VBD	_	0	root	_	_
15	a	a	DT	DT	_	19	det	_	_
16	significantly	significantly	RB	RB	_	17	advmod	_	_
17	enhanced	enhance	VBN	VBN	_	19	amod	_	_
18	chemotactic	chemotactic	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	14	dobj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	neutrophils	neutrophil	NNS	NNS	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	eosinophils	eosinophil	NNS	NNS	_	21	conj	_	_
24	,	,	,	,	_	19	punct	_	_
25	which	which	WDT	WDT	_	28	nsubjpass	_	_
26	was	be	VBD	VBD	_	28	auxpass	_	_
27	significantly	significantly	RB	RB	_	28	advmod	_	_
28	inhibited	inhibit	VBN	VBN	_	19	acl:relcl	_	_
29	by	by	IN	IN	_	30	case	_	_
30	pretreatment	pretreatment	NN	NN	_	28	nmod	_	_
31	with	with	IN	IN	_	32	case	_	_
32	anti-IL-8	anti-il-8	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	anti-RANTES	anti-rantes	JJ	JJ	_	32	conj	_	_
35	neutralizing	neutralizing	NN	NN	_	36	compound	_	_
36	antibodies	antibody	NNS	NNS	_	32	dep	_	_
37	,	,	,	,	_	28	punct	_	_
38	respectively	respectively	RB	RB	_	28	advmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	5	nsubj	_	_
2	:	:	:	:	_	5	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	chemokine	chemokine	NN	NN	_	9	compound	_	_
9	pathways	pathway	NNS	NNS	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	modulated	modulate	VBN	VBN	_	5	ccomp	_	_
12	by	by	IN	IN	_	13	case	_	_
13	DEP-PAHs	dep-pah	NNS	NNS	_	11	nmod	_	_
14	at	at	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	level	level	NN	NN	_	11	nmod	_	_
18	,	,	,	,	_	5	punct	_	_
19	reinforcing	reinforce	VBG	VBG	_	5	xcomp	_	_
20	the	the	DT	DT	_	21	det	_	_
21	idea	idea	NN	NN	_	19	dobj	_	_
22	that	that	IN	IN	_	30	mark	_	_
23	the	the	DT	DT	_	24	det	_	_
24	development	development	NN	NN	_	30	nsubjpass	_	_
25	of	of	IN	IN	_	27	case	_	_
26	inflammatory	inflammatory	JJ	JJ	_	27	amod	_	_
27	reactions	reaction	NNS	NNS	_	24	nmod	_	_
28	might	might	MD	MD	_	30	aux	_	_
29	be	be	VB	VB	_	30	auxpass	_	_
30	affected	affect	VBN	VBN	_	21	dep	_	_
31	by	by	IN	IN	_	34	case	_	_
32	diesel	diesel	NN	NN	_	34	compound	_	_
33	exhaust	exhaust	NN	NN	_	34	compound	_	_
34	emission	emission	NN	NN	_	30	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	Binding	binding	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	YY1	yy1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	Oct1	oct1	NN	NN	_	3	conj	_	_
6	to	to	TO	TO	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	novel	novel	JJ	JJ	_	9	amod	_	_
9	element	element	NN	NN	_	1	nmod	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	downregulates	downregulate	VBZ	VBZ	_	9	acl:relcl	_	_
12	expression	expression	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IL-5	il-5	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	BACKGROUND	background	NN	NN	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	IL-5	il-5	NN	NN	_	4	nsubj	_	_
4	controls	control	VBZ	VBZ	_	0	root	_	_
5	development	development	NN	NN	_	4	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	eosinophilia	eosinophilia	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	shown	show	VBN	VBN	_	4	conj	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	involved	involve	VBN	VBN	_	11	xcomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	pathogenesis	pathogenesis	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	allergic	allergic	JJ	JJ	_	20	amod	_	_
20	diseases	disease	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	both	both	CC	CC	_	3	cc:preconj	_	_
3	atopic	atopic	JJ	JJ	_	6	amod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	nonatopic	nonatopic	JJ	JJ	_	3	conj	_	_
6	asthma	asthma	NN	NN	_	12	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	elevated	elevated	JJ	JJ	_	9	amod	_	_
9	IL-5	il-5	NN	NN	_	12	nsubjpass	_	_
10	has	have	VBZ	VBZ	_	12	aux	_	_
11	been	be	VBN	VBN	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	peripheral	peripheral	JJ	JJ	_	15	amod	_	_
15	blood	blood	NN	NN	_	12	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	18	det	_	_
18	airways	airway	NNS	NNS	_	15	conj	_	_
19	.	.	.	.	_	12	punct	_	_

1	IL-5	il-5	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	produced	produce	VBN	VBN	_	0	root	_	_
4	mainly	mainly	RB	RB	_	3	advmod	_	_
5	by	by	IN	IN	_	8	case	_	_
6	activated	activate	VBN	VBN	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	expression	expression	NN	NN	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	regulated	regulate	VBN	VBN	_	3	conj	_	_
15	at	at	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	level	level	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	5	nsubj	_	_
2	:	:	:	:	_	5	punct	_	_
3	This	this	DT	DT	_	4	det	_	_
4	study	study	NN	NN	_	5	nsubj	_	_
5	focuses	focus	VBZ	VBZ	_	0	root	_	_
6	on	on	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	IL-5	il-5	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	hIL-5	hil-5	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	promoter	promoter	NN	NN	_	9	nmod	_	_
18	and	and	CC	CC	_	9	cc	_	_
19	characterization	characterization	NN	NN	_	9	conj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	cis-regulatory	cis-regulatory	JJ	JJ	_	22	amod	_	_
22	elements	element	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factors	factor	NNS	NNS	_	22	conj	_	_
26	involved	involve	VBN	VBN	_	22	acl	_	_
27	in	in	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	suppression	suppression	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	IL-5	il-5	NN	NN	_	32	compound	_	_
32	transcription	transcription	NN	NN	_	29	nmod	_	_
33	in	in	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	METHODS	method	NNS	NNS	_	8	nsubj	_	_
2	:	:	:	:	_	8	punct	_	_
3	Methods	method	NNS	NNS	_	8	nsubj	_	_
4	used	use	VBN	VBN	_	3	acl	_	_
5	in	in	IN	IN	_	7	case	_	_
6	this	this	DT	DT	_	7	det	_	_
7	study	study	NN	NN	_	4	nmod	_	_
8	include	include	VBP	VBP	_	0	root	_	_
9	DNase	dnase	NN	NN	_	12	compound	_	_
10	I	i	CD	CD	_	12	nummod	_	_
11	footprint	footprint	NN	NN	_	12	compound	_	_
12	assays	assay	NNS	NNS	_	8	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	electrophoretic	electrophoretic	JJ	JJ	_	17	amod	_	_
15	mobility	mobility	NN	NN	_	17	compound	_	_
16	shift	shift	NN	NN	_	17	compound	_	_
17	assays	assay	NNS	NNS	_	12	conj	_	_
18	,	,	,	,	_	12	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	functional	functional	JJ	JJ	_	21	amod	_	_
21	analysis	analysis	NN	NN	_	12	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	mammalian	mammalian	JJ	JJ	_	25	amod	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	transfection	transfection	NN	NN	_	21	nmod	_	_
26	involving	involve	VBG	VBG	_	28	case	_	_
27	deletion	deletion	NN	NN	_	28	compound	_	_
28	analysis	analysis	NN	NN	_	21	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	site-directed	site-directed	JJ	JJ	_	31	amod	_	_
31	mutagenesis	mutagenesis	NN	NN	_	28	conj	_	_
32	.	.	.	.	_	8	punct	_	_

1	RESULTS	result	NNS	NNS	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	0	root	_	_
5	5	5	CD	CD	_	6	nummod	_	_
6	protein	protein	NN	NN	_	4	dobj	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	regions	region	NNS	NNS	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	BRs	br	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	located	located	JJ	JJ	_	6	dep	_	_
13	within	within	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	proximal	proximal	JJ	JJ	_	17	amod	_	_
16	hIL-5	hil-5	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Functional	functional	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	BRs	br	NNS	NNS	_	8	nsubjpass	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	involved	involve	VBN	VBN	_	3	ccomp	_	_
9	in	in	IN	IN	_	10	case	_	_
10	control	control	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	hIL-5	hil-5	NN	NN	_	14	compound	_	_
13	promoter	promoter	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Two	two	CD	CD	_	20	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	regions	region	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	1	punct	_	_
6	BR3	br3	NN	NN	_	1	appos	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	BR4	br4	NN	NN	_	6	conj	_	_
9	located	located	JJ	JJ	_	1	dep	_	_
10	at	at	IN	IN	_	11	case	_	_
11	positions	position	NNS	NNS	_	9	nmod	_	_
12	-102	-102	CD	CD	_	11	nummod	_	_
13	to	to	TO	TO	_	11	dep	_	_
14	-73	-73	CD	CD	_	11	dep	_	_
15	,	,	,	,	_	20	punct	_	_
16	have	have	VBP	VBP	_	20	aux	_	_
17	not	not	RB	RB	_	20	neg	_	_
18	previously	previously	RB	RB	_	20	advmod	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	described	describe	VBN	VBN	_	0	root	_	_
21	as	as	IN	IN	_	22	case	_	_
22	regulators	regulator	NNS	NNS	_	20	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	IL-5	il-5	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	BR3	br3	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	7	nsubj	_	_
7	contains	contain	VBZ	VBZ	_	2	ccomp	_	_
8	a	a	DT	DT	_	12	det	_	_
9	novel	novel	JJ	JJ	_	12	amod	_	_
10	negative	negative	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	element	element	NN	NN	_	7	dobj	_	_
13	located	located	JJ	JJ	_	12	dep	_	_
14	at	at	IN	IN	_	15	case	_	_
15	positions	position	NNS	NNS	_	13	nmod	_	_
16	-90	-90	CD	CD	_	15	nummod	_	_
17	to	to	TO	TO	_	15	dep	_	_
18	-79	-79	CD	CD	_	15	dep	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	hIL-5	hil-5	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	which	which	WDT	WDT	_	25	nsubj	_	_
25	binds	bind	VBZ	VBZ	_	22	acl:relcl	_	_
26	Oct1	oct1	NN	NN	_	25	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	octamer-like	octamer-like	JJ	JJ	_	26	conj	_	_
29	,	,	,	,	_	26	punct	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	YY1	yy1	NN	NN	_	33	compound	_	_
32	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
33	factors	factor	NNS	NNS	_	26	conj	_	_
34	.	.	.	.	_	2	punct	_	_

1	Substitution	substitution	NN	NN	_	2	compound	_	_
2	mutations	mutation	NNS	NNS	_	16	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	which	which	WDT	WDT	_	5	nsubj	_	_
5	abolished	abolish	VBD	VBD	_	2	acl:relcl	_	_
6	binding	binding	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	these	these	DT	DT	_	9	det	_	_
9	proteins	protein	NNS	NNS	_	6	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	BR3	br3	NN	NN	_	13	compound	_	_
13	sequence	sequence	NN	NN	_	6	nmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	increased	increase	VBD	VBD	_	0	root	_	_
17	hIL-5	hil-5	NN	NN	_	19	compound	_	_
18	promoter	promoter	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	activated	activate	VBN	VBN	_	23	amod	_	_
22	T	t	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	16	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	4	nsubj	_	_
2	:	:	:	:	_	4	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	24	mark	_	_
6	Oct1	oct1	NN	NN	_	24	nsubjpass	_	_
7	,	,	,	,	_	6	punct	_	_
8	YY1	yy1	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	octamer-like	octamer-like	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	6	conj	_	_
13	binding	bind	VBG	VBG	_	6	acl	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	-90/-79	-90/-79	CD	CD	_	17	nummod	_	_
17	sequence	sequence	NN	NN	_	13	nmod	_	_
18	within	within	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	proximal	proximal	JJ	JJ	_	22	amod	_	_
21	IL-5	il-5	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	17	nmod	_	_
23	are	be	VBP	VBP	_	24	auxpass	_	_
24	involved	involve	VBN	VBN	_	4	ccomp	_	_
25	in	in	IN	IN	_	26	case	_	_
26	suppression	suppression	NN	NN	_	24	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	IL-5	il-5	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Direct	direct	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	hematopoietic	hematopoietic	JJ	JJ	_	6	amod	_	_
5	transcription	transcription	NN	NN	_	6	compound	_	_
6	factors	factor	NNS	NNS	_	2	nmod	_	_
7	PU.1	pu.1	NN	NN	_	6	dep	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	GATA-1	gata-1	NN	NN	_	7	conj	_	_
10	:	:	:	:	_	2	punct	_	_
11	functional	functional	JJ	JJ	_	12	amod	_	_
12	antagonism	antagonism	NN	NN	_	2	dep	_	_
13	in	in	IN	IN	_	15	case	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Malignant	malignant	JJ	JJ	_	2	amod	_	_
2	transformation	transformation	NN	NN	_	4	nsubj	_	_
3	usually	usually	RB	RB	_	4	advmod	_	_
4	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
5	terminal	terminal	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	differentiation	differentiation	NN	NN	_	4	dobj	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	precise	precise	JJ	JJ	_	11	amod	_	_
11	mechanisms	mechanism	NNS	NNS	_	15	nsubjpass	_	_
12	involved	involve	VBN	VBN	_	11	acl	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	understood	understand	VBN	VBN	_	4	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	PU.1	pu.1	NN	NN	_	8	nsubj	_	_
2	is	be	VBZ	VBZ	_	8	cop	_	_
3	a	a	DT	DT	_	8	det	_	_
4	hematopoietic-specific	hematopoietic-specific	JJ	JJ	_	8	amod	_	_
5	Ets	ets	NN	NN	_	8	compound	_	_
6	family	family	NN	NN	_	8	compound	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	11	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	8	acl:relcl	_	_
12	for	for	IN	IN	_	13	case	_	_
13	development	development	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	some	some	DT	DT	_	19	det	_	_
16	lymphoid	lymphoid	JJ	JJ	_	19	amod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	myeloid	myeloid	JJ	JJ	_	16	conj	_	_
19	lineages	lineage	NNS	NNS	_	13	nmod	_	_
20	.	.	.	.	_	8	punct	_	_

1	PU.1	pu.1	NN	NN	_	4	nsubj	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	act	act	VB	VB	_	0	root	_	_
5	as	as	IN	IN	_	7	case	_	_
6	an	a	DT	DT	_	7	det	_	_
7	oncoprotein	oncoprotein	NN	NN	_	4	nmod	_	_
8	as	as	IN	IN	_	9	case	_	_
9	activation	activation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	its	its	PRP$	PRP$	_	12	nmod:poss	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	precursors	precursor	NNS	NNS	_	12	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	proviral	proviral	JJ	JJ	_	18	amod	_	_
18	insertion	insertion	NN	NN	_	12	nmod	_	_
19	or	or	CC	CC	_	4	cc	_	_
20	transgenesis	transgenesis	NN	NN	_	21	nsubj	_	_
21	causes	cause	VBZ	VBZ	_	4	conj	_	_
22	erythroleukemias	erythroleukemia	NNS	NNS	_	21	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	mice	mouse	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Restoration	restoration	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	terminal	terminal	JJ	JJ	_	4	amod	_	_
4	differentiation	differentiation	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	12	case	_	_
6	the	the	DT	DT	_	12	det	_	_
7	mouse	mouse	NN	NN	_	8	compound	_	_
8	erythroleukemia	erythroleukemia	NN	NN	_	12	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MEL	mel	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	requires	require	VBZ	VBZ	_	0	root	_	_
14	a	a	DT	DT	_	15	det	_	_
15	decline	decline	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	level	level	NN	NN	_	13	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	PU.1	pu.1	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	13	punct	_	_
22	indicating	indicate	VBG	VBG	_	13	advcl	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	PU.1	pu.1	NN	NN	_	26	nsubj	_	_
25	can	can	MD	MD	_	26	aux	_	_
26	block	block	VB	VB	_	22	ccomp	_	_
27	erythroid	erythroid	JJ	JJ	_	28	amod	_	_
28	differentiation	differentiation	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	13	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	investigate	investigate	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mechanism	mechanism	NN	NN	_	3	dobj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	which	which	WDT	WDT	_	9	nmod	_	_
8	PU.1	pu.1	NN	NN	_	9	nsubj	_	_
9	interferes	interfere	VBZ	VBZ	_	5	acl:relcl	_	_
10	with	with	IN	IN	_	12	case	_	_
11	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	PU.1	pu.1	NN	NN	_	5	nsubj	_	_
5	interacts	interact	VBZ	VBZ	_	2	ccomp	_	_
6	directly	directly	RB	RB	_	5	advmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	GATA-1	gata-1	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	a	a	DT	DT	_	14	det	_	_
11	zinc	zinc	NN	NN	_	14	compound	_	_
12	finger	finger	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	8	appos	_	_
15	required	require	VBN	VBN	_	14	acl	_	_
16	for	for	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	differentiation	differentiation	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Interaction	interaction	NN	NN	_	6	nsubj	_	_
2	between	between	IN	IN	_	3	case	_	_
3	PU.1	pu.1	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	GATA-1	gata-1	NN	NN	_	3	conj	_	_
6	requires	require	VBZ	VBZ	_	0	root	_	_
7	intact	intact	JJ	JJ	_	9	amod	_	_
8	DNA-binding	dna-binding	JJ	JJ	_	9	amod	_	_
9	domains	domain	NNS	NNS	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	both	both	DT	DT	_	12	det	_	_
12	proteins	protein	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	PU.1	pu.1	NN	NN	_	2	nsubj	_	_
2	represses	repress	VBZ	VBZ	_	0	root	_	_
3	GATA-1-mediated	gata-1-mediated	JJ	JJ	_	5	amod	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activation	activation	NN	NN	_	2	dobj	_	_
6	.	.	.	.	_	2	punct	_	_

1	Both	both	CC	CC	_	4	cc:preconj	_	_
2	the	the	DT	DT	_	4	dep	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	binding	binding	NN	NN	_	11	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	transactivation	transactivation	NN	NN	_	7	compound	_	_
7	domains	domain	NNS	NNS	_	4	conj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PU.1	pu.1	NN	NN	_	4	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	repression	repression	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	both	both	DT	DT	_	16	det	_	_
16	domains	domain	NNS	NNS	_	19	nsubjpass	_	_
17	are	be	VBP	VBP	_	19	auxpass	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	needed	need	VBN	VBN	_	11	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	block	block	VB	VB	_	19	xcomp	_	_
22	terminal	terminal	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	21	dobj	_	_
24	in	in	IN	IN	_	26	case	_	_
25	MEL	mel	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	ectopic	ectopic	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	PU.1	pu.1	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Xenopus	xenopus	NN	NN	_	11	compound	_	_
11	embryos	embryo	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	sufficient	sufficient	JJ	JJ	_	3	ccomp	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	block	block	VB	VB	_	13	xcomp	_	_
16	erythropoiesis	erythropoiesis	NN	NN	_	15	dobj	_	_
17	during	during	IN	IN	_	19	case	_	_
18	normal	normal	JJ	JJ	_	19	amod	_	_
19	development	development	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Furthermore	furthermore	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	introduction	introduction	NN	NN	_	16	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	exogenous	exogenous	JJ	JJ	_	6	amod	_	_
6	GATA-1	gata-1	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	MEL	mel	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	3	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Xenopus	xenopus	NN	NN	_	13	compound	_	_
13	embryos	embryo	NNS	NNS	_	10	conj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	explants	explant	NNS	NNS	_	10	conj	_	_
16	relieves	relieve	VBZ	VBZ	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	block	block	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	differentiation	differentiation	NN	NN	_	18	nmod	_	_
22	imposed	impose	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	PU.1	pu.1	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	16	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	stoichiometry	stoichiometry	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	13	case	_	_
8	directly	directly	RB	RB	_	9	advmod	_	_
9	interacting	interact	VBG	VBG	_	13	amod	_	_
10	but	but	CC	CC	_	9	cc	_	_
11	opposing	oppose	VBG	VBG	_	9	conj	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	6	nmod	_	_
14	may	may	MD	MD	_	18	aux	_	_
15	be	be	VB	VB	_	18	cop	_	_
16	a	a	DT	DT	_	18	det	_	_
17	crucial	crucial	JJ	JJ	_	18	amod	_	_
18	determinant	determinant	NN	NN	_	3	ccomp	_	_
19	governing	govern	VBG	VBG	_	18	acl	_	_
20	processes	process	NNS	NNS	_	19	dobj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	normal	normal	JJ	JJ	_	23	amod	_	_
23	differentiation	differentiation	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	malignant	malignant	JJ	JJ	_	26	amod	_	_
26	transformation	transformation	NN	NN	_	23	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Potent	potent	NN	NN	_	4	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	stable	stable	JJ	JJ	_	1	conj	_	_
4	attenuation	attenuation	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	6	case	_	_
6	live-HIV-1	live-hiv-1	NN	NN	_	4	nmod	_	_
7	by	by	IN	IN	_	8	case	_	_
8	gain	gain	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	proteolysis-resistant	proteolysis-resistant	JJ	JJ	_	12	amod	_	_
12	inhibitor	inhibitor	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IkappaB-alphaS32/36A	ikappab-alphas32/36a	NN	NN	_	12	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	implications	implication	NNS	NNS	_	12	conj	_	_
21	for	for	IN	IN	_	23	case	_	_
22	vaccine	vaccine	NN	NN	_	23	compound	_	_
23	development	development	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Live-attenuated	live-attenuated	JJ	JJ	_	4	amod	_	_
2	human	human	JJ	JJ	_	4	amod	_	_
3	immunodeficiency	immunodeficiency	NN	NN	_	4	compound	_	_
4	viruses	virus	NNS	NNS	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HIVs	hiv	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	candidates	candidate	NNS	NNS	_	0	root	_	_
10	for	for	IN	IN	_	17	case	_	_
11	Acquired	acquire	VBN	VBN	_	13	amod	_	_
12	Immunodeficiency	immunodeficiency	NN	NN	_	13	compound	_	_
13	Syndrome	syndrome	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	AIDS	aids	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	vaccine	vaccine	NN	NN	_	9	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	Based	base	VBN	VBN	_	10	case	_	_
2	on	on	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	simian	simian	JJ	JJ	_	6	amod	_	_
5	immunodeficiency	immunodeficiency	NN	NN	_	6	compound	_	_
6	virus	virus	NN	NN	_	10	compound	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	SIV	siv	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	model	model	NN	NN	_	27	advcl	_	_
11	for	for	IN	IN	_	12	case	_	_
12	AIDS	aids	NN	NN	_	10	nmod	_	_
13	,	,	,	,	_	27	punct	_	_
14	loss-of-function	loss-of-function	NN	NN	_	27	nsubjpass	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	e.g.	e.g.	FW	FW	_	17	dep	_	_
17	deletion	deletion	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	accessory	accessory	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	17	nmod	_	_
21	such	such	JJ	JJ	_	23	case	_	_
22	as	as	IN	IN	_	21	mwe	_	_
23	nef	nef	NN	NN	_	20	nmod	_	_
24	)	)	-RRB-	-RRB-	_	17	punct	_	_
25	has	have	VBZ	VBZ	_	27	aux	_	_
26	been	be	VBN	VBN	_	27	auxpass	_	_
27	forwarded	forward	VBN	VBN	_	0	root	_	_
28	as	as	IN	IN	_	31	case	_	_
29	a	a	DT	DT	_	31	det	_	_
30	primary	primary	JJ	JJ	_	31	amod	_	_
31	approach	approach	NN	NN	_	27	nmod	_	_
32	for	for	IN	IN	_	33	mark	_	_
33	creating	create	VBG	VBG	_	31	acl	_	_
34	enfeebled	enfeebled	JJ	JJ	_	39	amod	_	_
35	,	,	,	,	_	34	punct	_	_
36	but	but	CC	CC	_	34	cc	_	_
37	replication-competent	replication-competent	JJ	JJ	_	34	conj	_	_
38	,	,	,	,	_	39	punct	_	_
39	HIV-1/SIV	hiv-1/siv	NN	NN	_	33	dobj	_	_
40	.	.	.	.	_	27	punct	_	_

1	Regrettably	regrettably	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	recent	recent	JJ	JJ	_	4	amod	_	_
4	evidence	evidence	NN	NN	_	5	nsubj	_	_
5	suggests	suggest	VBZ	VBZ	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	loss-of-function	loss-of-function	NN	NN	_	11	nsubj	_	_
8	alone	alone	RB	RB	_	7	amod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	always	always	RB	RB	_	5	ccomp	_	_
12	sufficient	sufficient	JJ	JJ	_	11	xcomp	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	prevent	prevent	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	emergence	emergence	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	virulent	virulent	JJ	JJ	_	19	amod	_	_
19	mutants	mutant	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	New	new	NN	NN	_	2	compound	_	_
2	strategies	strategy	NNS	NNS	_	11	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	attenuate	attenuate	VBP	VBP	_	2	acl:relcl	_	_
5	via	via	IN	IN	_	6	case	_	_
6	mechanisms	mechanism	NNS	NNS	_	4	nmod	_	_
7	distinct	distinct	JJ	JJ	_	6	amod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	loss-of-function	loss-of-function	NN	NN	_	7	nmod	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	needed	need	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	enhancing	enhance	VBG	VBG	_	11	advcl	_	_
14	the	the	DT	DT	_	16	det	_	_
15	safety	safety	NN	NN	_	16	compound	_	_
16	phenotype	phenotype	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	viral	viral	JJ	JJ	_	19	amod	_	_
19	genome	genome	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	propose	propose	VBP	VBP	_	0	root	_	_
5	gain-of-function	gain-of-function	NN	NN	_	4	dobj	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	5	acl	_	_
9	simultaneously	simultaneously	RB	RB	_	8	advmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	loss-of-function	loss-of-function	NN	NN	_	8	nmod	_	_
12	as	as	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	novel	novel	JJ	JJ	_	15	amod	_	_
15	approach	approach	NN	NN	_	8	nmod	_	_
16	for	for	IN	IN	_	17	mark	_	_
17	attenuating	attenuate	VBG	VBG	_	15	acl	_	_
18	HIV-1	hiv-1	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	constructed	construct	VBN	VBN	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	HIV-1	hiv-1	NN	NN	_	6	compound	_	_
6	genome	genome	NN	NN	_	3	dobj	_	_
7	carrying	carry	VBG	VBG	_	6	acl	_	_
8	the	the	DT	DT	_	9	det	_	_
9	cDNA	cdna	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	proteolysis-resistant	proteolysis-resistant	JJ	JJ	_	15	amod	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	factor-kappaB	factor-kappab	NN	NN	_	15	compound	_	_
15	inhibitor	inhibitor	NN	NN	_	9	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	IkappaB-alphaS32/36A	ikappab-alphas32/36a	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	nef	nef	NN	NN	_	22	compound	_	_
22	region	region	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	4	nsubj	_	_
2	expressing	express	VBG	VBG	_	1	acl	_	_
3	IkappaB-alphaS32/36A	ikappab-alphas32/36a	NN	NN	_	2	dobj	_	_
4	down-regulates	down-regulate	VBZ	VBZ	_	0	root	_	_
5	viral	viral	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	4	cc	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	highly	highly	RB	RB	_	10	advmod	_	_
10	attenuated	attenuate	VBN	VBN	_	4	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	both	both	CC	CC	_	13	cc:preconj	_	_
13	Jurkat	jurkat	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
16	blood	blood	NN	NN	_	18	compound	_	_
17	mononuclear	mononuclear	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	conj	_	_
19	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	formal	formal	JJ	JJ	_	4	amod	_	_
4	proof	proof	NN	NN	_	2	dobj	_	_
5	that	that	IN	IN	_	13	mark	_	_
6	the	the	DT	DT	_	10	det	_	_
7	phenotypic	phenotypic	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	attenuating	attenuating	NN	NN	_	7	conj	_	_
10	characteristics	characteristic	NNS	NNS	_	13	nsubj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	IkappaB-alphaS32/36A	ikappab-alphas32/36a	NN	NN	_	10	nmod	_	_
13	permit	permit	VBP	VBP	_	4	dep	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	stable	stable	JJ	JJ	_	16	amod	_	_
16	maintenance	maintenance	NN	NN	_	13	dobj	_	_
17	in	in	IN	IN	_	22	case	_	_
18	a	a	DT	DT	_	22	det	_	_
19	live	live	JJ	JJ	_	22	amod	_	_
20	,	,	,	,	_	19	punct	_	_
21	replicating	replicate	VBG	VBG	_	19	dep	_	_
22	HIV-1	hiv-1	NN	NN	_	16	nmod	_	_
23	despite	despite	IN	IN	_	25	case	_	_
24	180	180	CD	CD	_	25	nummod	_	_
25	days	day	NNS	NNS	_	13	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	forced	forced	JJ	JJ	_	30	amod	_	_
28	ex	ex	FW	FW	_	30	amod	_	_
29	vivo	vivo	FW	FW	_	28	dep	_	_
30	passaging	passaging	NN	NN	_	25	nmod	_	_
31	in	in	IN	IN	_	33	case	_	_
32	tissue	tissue	NN	NN	_	33	compound	_	_
33	culture	culture	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	2	punct	_	_

1	As	as	IN	IN	_	6	mark	_	_
2	compared	compare	VBN	VBN	_	6	case	_	_
3	with	with	IN	IN	_	6	case	_	_
4	other	other	JJ	JJ	_	6	amod	_	_
5	open-reading	open-reading	JJ	JJ	_	6	amod	_	_
6	frames	frame	NNS	NNS	_	17	advcl	_	_
7	embedded	embedded	JJ	JJ	_	6	dep	_	_
8	into	into	IN	IN	_	10	case	_	_
9	HIV/SIV	hiv/siv	NN	NN	_	10	compound	_	_
10	genome	genome	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	17	punct	_	_
12	this	this	DT	DT	_	13	det	_	_
13	degree	degree	NN	NN	_	17	nsubj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	stability	stability	NN	NN	_	13	nmod	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	unprecedented	unprecedented	JJ	JJ	_	0	root	_	_
18	.	.	.	.	_	17	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	IkappaB-alphaS32/36A	ikappab-alphas32/36a	NN	NN	_	4	nsubj	_	_
4	offers	offer	VBZ	VBZ	_	0	root	_	_
5	proof-of-principle	proof-of-principle	NN	NN	_	4	dobj	_	_
6	that	that	IN	IN	_	23	mark	_	_
7	artifactually	artifactually	RB	RB	_	8	advmod	_	_
8	gained	gain	VBN	VBN	_	9	amod	_	_
9	functions	function	NNS	NNS	_	23	nsubj	_	_
10	,	,	,	,	_	12	punct	_	_
11	when	when	WRB	WRB	_	12	advmod	_	_
12	used	use	VBN	VBN	_	23	parataxis	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	attenuate	attenuate	VB	VB	_	12	xcomp	_	_
15	the	the	DT	DT	_	16	det	_	_
16	replication	replication	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	live	live	JJ	JJ	_	19	amod	_	_
19	HIV-1	hiv-1	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	can	can	MD	MD	_	23	aux	_	_
22	be	be	VB	VB	_	23	cop	_	_
23	stable	stable	JJ	JJ	_	5	dep	_	_
24	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	illustrate	illustrate	VBP	VBP	_	0	root	_	_
4	gain-of-function	gain-of-function	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	feasible	feasible	JJ	JJ	_	8	amod	_	_
8	strategy	strategy	NN	NN	_	3	nmod	_	_
9	for	for	IN	IN	_	10	mark	_	_
10	developing	develop	VBG	VBG	_	8	acl	_	_
11	safer	safer	JJR	JJR	_	13	amod	_	_
12	live-attenuated	live-attenuated	JJ	JJ	_	13	amod	_	_
13	HIVs	hiv	NNS	NNS	_	10	dobj	_	_
14	to	to	TO	TO	_	16	dep	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	tested	test	VBN	VBN	_	13	acl:relcl	_	_
17	as	as	IN	IN	_	18	case	_	_
18	candidates	candidate	NNS	NNS	_	16	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	AIDS	aids	NN	NN	_	21	compound	_	_
21	vaccine	vaccine	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	Oxidative	oxidative	JJ	JJ	_	2	amod	_	_
2	stress	stress	NN	NN	_	0	root	_	_
3	triggers	trigger	VBZ	VBZ	_	2	dep	_	_
4	STAT3	stat3	NN	NN	_	6	compound	_	_
5	tyrosine	tyrosine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	3	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	translocation	translocation	NN	NN	_	6	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Oxidizing	oxidizing	JJ	JJ	_	2	amod	_	_
2	agents	agent	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	powerful	powerful	JJ	JJ	_	5	amod	_	_
5	activators	activator	NNS	NNS	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	factors	factor	NNS	NNS	_	5	nmod	_	_
8	responsible	responsible	JJ	JJ	_	7	amod	_	_
9	for	for	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	activation	activation	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cytokine-encoding	cytokine-encoding	JJ	JJ	_	15	amod	_	_
15	genes	gene	NNS	NNS	_	12	nmod	_	_
16	involved	involve	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	tissue	tissue	NN	NN	_	19	compound	_	_
19	injury	injury	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	STAT3	stat3	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	a	a	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	6	dep	_	_
13	whose	whose	WP$	WP$	_	14	nmod:poss	_	_
14	activity	activity	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	modulated	modulate	VBN	VBN	_	12	acl:relcl	_	_
17	by	by	IN	IN	_	18	case	_	_
18	H2O2	h2o2	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	in	in	IN	IN	_	24	case	_	_
24	which	which	WDT	WDT	_	30	nmod	_	_
25	endogenous	endogenous	JJ	JJ	_	26	amod	_	_
26	catalase	catalase	NN	NN	_	30	nsubjpass	_	_
27	had	have	VBD	VBD	_	30	aux	_	_
28	previously	previously	RB	RB	_	30	advmod	_	_
29	been	be	VBN	VBN	_	30	auxpass	_	_
30	inhibited	inhibit	VBN	VBN	_	21	acl:relcl	_	_
31	.	.	.	.	_	5	punct	_	_

1	H2O2-induced	h2o2-induced	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	STAT3	stat3	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	form	form	VB	VB	_	3	acl	_	_
8	sequence-specific	sequence-specific	JJ	JJ	_	10	amod	_	_
9	DNA-bound	dna-bound	JJ	JJ	_	10	amod	_	_
10	complexes	complex	NNS	NNS	_	7	dobj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	evidenced	evidence	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	14	case	_	_
14	immunoblotting	immunoblotting	NN	NN	_	12	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	fractions	fraction	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	electrophoretic	electrophoretic	JJ	JJ	_	22	amod	_	_
20	mobility	mobility	NN	NN	_	22	compound	_	_
21	shift	shift	NN	NN	_	22	compound	_	_
22	assays	assay	NNS	NNS	_	17	conj	_	_
23	,	,	,	,	_	12	punct	_	_
24	and	and	CC	CC	_	12	cc	_	_
25	vanadate	vanadate	NN	NN	_	27	nsubjpass	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	found	find	VBN	VBN	_	12	conj	_	_
28	to	to	TO	TO	_	30	mark	_	_
29	strongly	strongly	RB	RB	_	30	advmod	_	_
30	synergize	synergize	VB	VB	_	27	xcomp	_	_
31	with	with	IN	IN	_	32	case	_	_
32	H2O2	h2o2	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	anti-STAT3	anti-stat3	JJ	JJ	_	4	amod	_	_
4	antibodies	antibody	NNS	NNS	_	6	nsubj	_	_
5	specifically	specifically	RB	RB	_	6	advmod	_	_
6	precipitated	precipitate	VBD	VBD	_	0	root	_	_
7	a	a	DT	DT	_	8	det	_	_
8	protein	protein	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	92	92	CD	CD	_	11	nummod	_	_
11	kDa	kda	NN	NN	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	becomes	become	VBZ	VBZ	_	8	acl:relcl	_	_
14	phosphorylated	phosphorylate	VBN	VBN	_	13	xcomp	_	_
15	on	on	IN	IN	_	16	case	_	_
16	tyrosine	tyrosine	NN	NN	_	14	nmod	_	_
17	upon	upon	IN	IN	_	19	case	_	_
18	lymphocyte	lymphocyte	NN	NN	_	19	compound	_	_
19	treatment	treatment	NN	NN	_	14	nmod	_	_
20	with	with	IN	IN	_	21	case	_	_
21	H2O2	h2o2	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Phenylarsine	phenylarsine	NN	NN	_	2	compound	_	_
2	oxide	oxide	NN	NN	_	17	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	tyrosine	tyrosine	NN	NN	_	7	compound	_	_
6	phosphatase	phosphatase	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	2	appos	_	_
8	,	,	,	,	_	2	punct	_	_
9	and	and	CC	CC	_	2	cc	_	_
10	genistein	genistein	NN	NN	_	2	conj	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	15	det	_	_
13	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
14	kinase	kinase	NN	NN	_	15	compound	_	_
15	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
16	,	,	,	,	_	17	punct	_	_
17	cooperated	cooperate	VBD	VBD	_	0	root	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cancelled	cancel	VBD	VBD	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	respectively	respectively	RB	RB	_	17	advmod	_	_
22	,	,	,	,	_	17	punct	_	_
23	the	the	DT	DT	_	27	det	_	_
24	H2O2-promoted	h2o2-promoted	JJ	JJ	_	27	amod	_	_
25	STAT3	stat3	NN	NN	_	27	compound	_	_
26	nuclear	nuclear	JJ	JJ	_	27	amod	_	_
27	translocation	translocation	NN	NN	_	17	dobj	_	_
28	.	.	.	.	_	17	punct	_	_

1	Evidence	evidence	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	presented	present	VBN	VBN	_	0	root	_	_
5	,	,	,	,	_	6	punct	_	_
6	using	use	VBG	VBG	_	4	parataxis	_	_
7	Fe2+/Cu2+	fe2+/cu2+	JJ	JJ	_	8	amod	_	_
8	ions	ion	NNS	NNS	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	that.	that.	IN	IN	_	24	mark	_	_
11	OH	oh	NN	NN	_	24	nsubj	_	_
12	generated	generate	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	14	case	_	_
14	H2O2	h2o2	NN	NN	_	12	nmod	_	_
15	through	through	IN	IN	_	17	case	_	_
16	Fenton	fenton	NN	NN	_	17	compound	_	_
17	reactions	reaction	NNS	NNS	_	12	nmod	_	_
18	could	could	MD	MD	_	24	aux	_	_
19	be	be	VB	VB	_	24	cop	_	_
20	a	a	DT	DT	_	24	det	_	_
21	candidate	candidate	NN	NN	_	24	compound	_	_
22	oxygen	oxygen	NN	NN	_	24	compound	_	_
23	reactive	reactive	JJ	JJ	_	24	amod	_	_
24	species	species	NNS	NNS	_	4	advcl	_	_
25	to	to	TO	TO	_	27	mark	_	_
26	directly	directly	RB	RB	_	27	advmod	_	_
27	activate	activate	VB	VB	_	24	acl	_	_
28	STAT3	stat3	NN	NN	_	27	dobj	_	_
29	.	.	.	.	_	4	punct	_	_

1	Present	present	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	H2O2	h2o2	NN	NN	_	9	nsubj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	vanadate	vanadate	NN	NN	_	5	conj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	likely	likely	JJ	JJ	_	3	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	inhibit	inhibit	VB	VB	_	9	xcomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	activity	activity	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	intracellular	intracellular	JJ	JJ	_	17	amod	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphatase	phosphatase	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	s	s	NNS	NNS	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	11	punct	_	_
22	leading	lead	VBG	VBG	_	27	case	_	_
23	to	to	TO	TO	_	27	case	_	_
24	enhanced	enhance	VBN	VBN	_	27	amod	_	_
25	STAT3	stat3	NN	NN	_	27	compound	_	_
26	tyrosine	tyrosine	NN	NN	_	27	compound	_	_
27	phosphorylation	phosphorylation	NN	NN	_	11	advcl	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	hence	hence	RB	RB	_	31	advmod	_	_
30	its	its	PRP$	PRP$	_	31	nmod:poss	_	_
31	translocation	translocation	NN	NN	_	27	conj	_	_
32	to	to	TO	TO	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	nucleus	nucleus	NN	NN	_	31	nmod	_	_
35	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	the	the	DT	DT	_	8	det	_	_
6	DNA	dna	NN	NN	_	8	compound	_	_
7	binding	binding	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	13	nsubjpass	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT3	stat3	NN	NN	_	8	nmod	_	_
11	can	can	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	modulated	modulate	VBN	VBN	_	3	ccomp	_	_
14	by	by	IN	IN	_	16	case	_	_
15	oxidizing	oxidize	VBG	VBG	_	16	amod	_	_
16	agents	agent	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	provide	provide	VBP	VBP	_	13	conj	_	_
19	a	a	DT	DT	_	20	det	_	_
20	framework	framework	NN	NN	_	18	dobj	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	understand	understand	VB	VB	_	20	acl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	effects	effect	NNS	NNS	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	oxidative	oxidative	JJ	JJ	_	27	amod	_	_
27	stress	stress	NN	NN	_	24	nmod	_	_
28	on	on	IN	IN	_	32	case	_	_
29	the	the	DT	DT	_	32	det	_	_
30	JAK-STAT	jak-stat	NN	NN	_	32	compound	_	_
31	signaling	signaling	NN	NN	_	32	compound	_	_
32	pathway	pathway	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	3	amod	_	_
2	alveolar	alveolar	JJ	JJ	_	3	amod	_	_
3	macrophages	macrophage	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	markedly	markedly	RB	RB	_	6	advmod	_	_
6	deficient	deficient	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	REF-1	ref-1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-1	ap-1	NN	NN	_	13	compound	_	_
11	DNA	dna	NN	NN	_	13	compound	_	_
12	binding	binding	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	8	conj	_	_
14	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	9	mark	_	_
2	many	many	JJ	JJ	_	3	amod	_	_
3	functions	function	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	alveolar	alveolar	JJ	JJ	_	7	amod	_	_
7	macrophages	macrophage	NNS	NNS	_	3	nmod	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	altered	alter	VBN	VBN	_	35	advcl	_	_
10	compared	compare	VBN	VBN	_	14	case	_	_
11	with	with	IN	IN	_	14	case	_	_
12	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
13	precursor	precursor	NN	NN	_	14	compound	_	_
14	cell	cell	NN	NN	_	9	advcl	_	_
15	,	,	,	,	_	14	punct	_	_
16	the	the	DT	DT	_	18	det	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	monocyte	monocyte	NN	NN	_	14	appos	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	monocyte	monocyte	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	35	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	reason	reason	NN	NN	_	35	nsubjpass	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	s	s	NNS	NNS	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	for	for	IN	IN	_	31	case	_	_
29	these	these	DT	DT	_	31	det	_	_
30	functional	functional	JJ	JJ	_	31	amod	_	_
31	changes	change	NNS	NNS	_	24	nmod	_	_
32	have	have	VBP	VBP	_	35	aux	_	_
33	not	not	RB	RB	_	35	neg	_	_
34	been	be	VBN	VBN	_	35	auxpass	_	_
35	determined	determine	VBN	VBN	_	0	root	_	_
36	.	.	.	.	_	35	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	recently	recently	RB	RB	_	3	advmod	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	human	human	JJ	JJ	_	7	amod	_	_
6	alveolar	alveolar	JJ	JJ	_	7	amod	_	_
7	macrophages	macrophage	NNS	NNS	_	10	nsubj	_	_
8	do	do	VBP	VBP	_	10	aux	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	express	express	VB	VB	_	3	ccomp	_	_
11	AP-1	ap-1	NN	NN	_	14	compound	_	_
12	DNA	dna	NN	NN	_	14	compound	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	Monick	Monick	NNP	NNP	_	19	compound	_	_
17	,	,	,	,	_	19	punct	_	_
18	M.	M.	NNP	NNP	_	19	appos	_	_
19	M.	M.	NNP	NNP	_	10	dep	_	_
20	,	,	,	,	_	19	punct	_	_
21	Carter	carter	NN	NN	_	24	compound	_	_
22	,	,	,	,	_	24	punct	_	_
23	A.	A.	NNP	NNP	_	24	dep	_	_
24	B.	B.	NNP	NNP	_	19	conj	_	_
25	,	,	,	,	_	19	punct	_	_
26	Gudmundsson	gudmundsson	NN	NN	_	28	compound	_	_
27	,	,	,	,	_	28	punct	_	_
28	G.	G.	NNP	NNP	_	19	conj	_	_
29	,	,	,	,	_	19	punct	_	_
30	Geist	Geist	NNP	NNP	_	33	compound	_	_
31	,	,	,	,	_	33	punct	_	_
32	L.	L.	NNP	NNP	_	33	appos	_	_
33	J.	J.	NNP	NNP	_	19	conj	_	_
34	,	,	,	,	_	19	punct	_	_
35	and	and	CC	CC	_	19	cc	_	_
36	Hunninghake	Hunninghake	NNP	NNP	_	39	compound	_	_
37	,	,	,	,	_	39	punct	_	_
38	G.	G.	NNP	NNP	_	39	appos	_	_
39	W.	W.	NNP	NNP	_	19	conj	_	_
40	(	(	-LRB-	-LRB-	_	41	punct	_	_
41	1998	1998	CD	CD	_	19	dep	_	_
42	)	)	-RRB-	-RRB-	_	41	punct	_	_
43	Am.	Am.	NNP	NNP	_	45	compound	_	_
44	J.	J.	NNP	NNP	_	45	compound	_	_
45	Physiol.	Physiol.	NNP	NNP	_	19	dep	_	_
46	275	275	CD	CD	_	45	nummod	_	_
47	,	,	,	,	_	19	punct	_	_
48	L389-L397	l389-l397	NN	NN	_	19	dep	_	_
49	)	)	-RRB-	-RRB-	_	19	punct	_	_
50	.	.	.	.	_	3	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	16	advcl	_	_
3	why	why	WRB	WRB	_	8	advmod	_	_
4	alveolar	alveolar	JJ	JJ	_	5	amod	_	_
5	macrophages	macrophage	NNS	NNS	_	8	nsubj	_	_
6	do	do	VBP	VBP	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	express	express	VB	VB	_	2	advcl	_	_
9	AP-1	ap-1	NN	NN	_	12	compound	_	_
10	DNA	dna	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	first	first	RB	RB	_	16	advmod	_	_
16	showed	show	VBD	VBD	_	0	root	_	_
17	that	that	IN	IN	_	19	mark	_	_
18	there	there	EX	EX	_	19	expl	_	_
19	was	be	VBD	VBD	_	16	ccomp	_	_
20	not	not	RB	RB	_	19	neg	_	_
21	a	a	DT	DT	_	22	det	_	_
22	decrease	decrease	NN	NN	_	19	nsubj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	expression	expression	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	FOS	fos	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	JUN	jun	NN	NN	_	27	conj	_	_
30	proteins	protein	NNS	NNS	_	27	dep	_	_
31	that	that	WDT	WDT	_	32	nsubj	_	_
32	make	make	VBP	VBP	_	27	acl:relcl	_	_
33	up	up	RP	RP	_	32	dep	_	_
34	the	the	DT	DT	_	36	det	_	_
35	AP-1	ap-1	NN	NN	_	36	compound	_	_
36	complex	complex	NN	NN	_	32	dobj	_	_
37	.	.	.	.	_	16	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	was	be	VBD	VBD	_	0	root	_	_
3	,	,	,	,	_	2	punct	_	_
4	however	however	RB	RB	_	2	advmod	_	_
5	,	,	,	,	_	2	punct	_	_
6	a	a	DT	DT	_	8	det	_	_
7	significant	significant	JJ	JJ	_	8	amod	_	_
8	difference	difference	NN	NN	_	2	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	amounts	amount	NNS	NNS	_	8	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	REF-1	ref-1	NN	NN	_	15	dep	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	regulates	regulate	VBZ	VBZ	_	17	dep	_	_
21	AP-1	ap-1	NN	NN	_	23	compound	_	_
22	DNA	dna	NN	NN	_	23	compound	_	_
23	binding	binding	NN	NN	_	20	dobj	_	_
24	by	by	IN	IN	_	25	mark	_	_
25	altering	alter	VBG	VBG	_	20	advcl	_	_
26	the	the	DT	DT	_	28	det	_	_
27	redox	redox	NN	NN	_	28	compound	_	_
28	status	status	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	33	case	_	_
30	FOS	fos	NN	NN	_	33	compound	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	JUN	jun	NN	NN	_	30	conj	_	_
33	proteins	protein	NNS	NNS	_	28	nmod	_	_
34	)	)	-RRB-	-RRB-	_	20	punct	_	_
35	,	,	,	,	_	15	punct	_	_
36	in	in	IN	IN	_	38	case	_	_
37	alveolar	alveolar	JJ	JJ	_	38	amod	_	_
38	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
39	compared	compare	VBN	VBN	_	41	case	_	_
40	with	with	IN	IN	_	41	case	_	_
41	monocytes	monocyte	NNS	NNS	_	38	nmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	,	,	,	,	_	13	punct	_	_
4	in	in	FW	FW	_	6	amod	_	_
5	vitro	vitro	FW	FW	_	4	dep	_	_
6	differentiation	differentiation	NN	NN	_	13	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	monocytes	monocyte	NNS	NNS	_	6	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	macrophage-like	macrophage-like	JJ	JJ	_	12	amod	_	_
12	cell	cell	NN	NN	_	6	nmod	_	_
13	resulted	result	VBD	VBD	_	0	root	_	_
14	in	in	IN	IN	_	16	case	_	_
15	decreased	decrease	VBN	VBN	_	16	amod	_	_
16	amounts	amount	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	REF-1	ref-1	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	addition	addition	NN	NN	_	14	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	REF-1	ref-1	NN	NN	_	3	nmod	_	_
6	from	from	IN	IN	_	8	case	_	_
7	activated	activate	VBN	VBN	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
9	to	to	TO	TO	_	13	case	_	_
10	alveolar	alveolar	JJ	JJ	_	13	amod	_	_
11	macrophage	macrophage	NN	NN	_	13	compound	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	proteins	protein	NNS	NNS	_	8	nmod	_	_
14	resulted	result	VBD	VBD	_	0	root	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	marked	marked	JJ	JJ	_	18	amod	_	_
18	increase	increase	NN	NN	_	14	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	AP-1	ap-1	NN	NN	_	22	compound	_	_
21	DNA	dna	NN	NN	_	22	compound	_	_
22	binding	binding	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	process	process	NN	NN	_	16	nsubjpass	_	_
8	of	of	IN	IN	_	9	case	_	_
9	differentiation	differentiation	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	monocytes	monocyte	NNS	NNS	_	9	nmod	_	_
12	into	into	IN	IN	_	14	case	_	_
13	alveolar	alveolar	JJ	JJ	_	14	amod	_	_
14	macrophages	macrophage	NNS	NNS	_	9	nmod	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	associated	associate	VBN	VBN	_	4	ccomp	_	_
17	with	with	IN	IN	_	19	case	_	_
18	a	a	DT	DT	_	19	det	_	_
19	loss	loss	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	REF-1	ref-1	NN	NN	_	24	compound	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	AP-1	ap-1	NN	NN	_	21	conj	_	_
24	activity	activity	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	explain	explain	VB	VB	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	part	part	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	some	some	DT	DT	_	4	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	functional	functional	JJ	JJ	_	13	amod	_	_
13	differences	difference	NNS	NNS	_	9	nmod	_	_
14	observed	observe	VBN	VBN	_	13	acl	_	_
15	for	for	IN	IN	_	17	case	_	_
16	alveolar	alveolar	JJ	JJ	_	17	amod	_	_
17	macrophages	macrophage	NNS	NNS	_	14	nmod	_	_
18	compared	compare	VBN	VBN	_	20	case	_	_
19	with	with	IN	IN	_	20	case	_	_
20	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Monocyte	monocyte	NN	NN	_	2	compound	_	_
2	adhesion	adhesion	NN	NN	_	10	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	spreading	spreading	NN	NN	_	2	conj	_	_
5	on	on	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	dependent	dependent	JJ	JJ	_	0	root	_	_
11	on	on	IN	IN	_	14	case	_	_
12	Rho-regulated	rho-regulated	JJ	JJ	_	14	amod	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	clustering	clustering	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	GTPase	gtpase	NN	NN	_	5	nsubjpass	_	_
3	Rho	rho	NN	NN	_	2	dep	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	mediate	mediate	VB	VB	_	5	xcomp	_	_
8	the	the	DT	DT	_	9	det	_	_
9	assembly	assembly	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	integrin-containing	integrin-containing	JJ	JJ	_	13	amod	_	_
12	focal	focal	JJ	JJ	_	13	amod	_	_
13	adhesions	adhesion	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	actin	actin	NN	NN	_	17	compound	_	_
16	stress	stress	NN	NN	_	17	compound	_	_
17	fibers	fiber	NNS	NNS	_	13	conj	_	_
18	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigate	investigate	VBP	VBP	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	Rho	rho	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	mark	_	_
10	regulating	regulate	VBG	VBG	_	6	acl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	distribution	distribution	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	monocyte-binding	monocyte-binding	JJ	JJ	_	16	amod	_	_
16	receptors	receptor	NNS	NNS	_	12	nmod	_	_
17	E-selectin	e-selectin	NN	NN	_	16	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	ICAM-1	icam-1	NN	NN	_	17	conj	_	_
20	,	,	,	,	_	17	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	VCAM-1	vcam-1	NN	NN	_	17	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	human	human	JJ	JJ	_	26	amod	_	_
25	endothelial	endothelial	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	16	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Inhibition	inhibition	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Rho	rho	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	with	with	IN	IN	_	7	case	_	_
6	C3	c3	NN	NN	_	7	compound	_	_
7	transferase	transferase	NN	NN	_	1	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	N19RhoA	n19rhoa	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	9	punct	_	_
11	a	a	DT	DT	_	15	det	_	_
12	dominant	dominant	JJ	JJ	_	15	amod	_	_
13	negative	negative	JJ	JJ	_	15	amod	_	_
14	RhoA	rhoa	NN	NN	_	15	compound	_	_
15	mutant	mutant	NN	NN	_	9	appos	_	_
16	,	,	,	,	_	17	punct	_	_
17	reduced	reduce	VBD	VBD	_	0	root	_	_
18	the	the	DT	DT	_	19	det	_	_
19	adhesion	adhesion	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	activated	activate	VBN	VBN	_	25	amod	_	_
24	endothelial	endothelial	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	19	nmod	_	_
26	and	and	CC	CC	_	17	cc	_	_
27	inhibited	inhibit	VBD	VBD	_	17	conj	_	_
28	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
29	spreading	spreading	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	17	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	after	after	IN	IN	_	6	case	_	_
6	pretreatment	pretreatment	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	cytochalasin	cytochalasin	NN	NN	_	12	compound	_	_
12	D	d	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	12	nmod	_	_
3	,	,	,	,	_	12	punct	_	_
4	dominant	dominant	JJ	JJ	_	6	amod	_	_
5	negative	negative	JJ	JJ	_	6	amod	_	_
6	Rac	rac	NN	NN	_	12	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	Cdc42	cdc42	NN	NN	_	6	conj	_	_
9	proteins	protein	NNS	NNS	_	6	dep	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	affect	affect	VB	VB	_	0	root	_	_
13	monocyte	monocyte	NN	NN	_	14	compound	_	_
14	adhesion	adhesion	NN	NN	_	12	dobj	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	spreading	spreading	NN	NN	_	14	conj	_	_
17	.	.	.	.	_	12	punct	_	_

1	C3	c3	NN	NN	_	2	compound	_	_
2	transferase	transferase	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	cytochalasin	cytochalasin	NN	NN	_	5	compound	_	_
5	D	d	NN	NN	_	2	conj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	alter	alter	VB	VB	_	0	root	_	_
9	the	the	DT	DT	_	11	det	_	_
10	expression	expression	NN	NN	_	11	compound	_	_
11	levels	level	NNS	NNS	_	8	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	monocyte-binding	monocyte-binding	JJ	JJ	_	14	amod	_	_
14	receptors	receptor	NNS	NNS	_	11	nmod	_	_
15	on	on	IN	IN	_	17	case	_	_
16	endothelial	endothelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	,	,	,	,	_	8	punct	_	_
19	but	but	CC	CC	_	8	cc	_	_
20	did	do	VBD	VBD	_	21	aux	_	_
21	inhibit	inhibit	VB	VB	_	8	conj	_	_
22	clustering	clustering	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	E-selectin	e-selectin	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	24	punct	_	_
26	ICAM-1	icam-1	NN	NN	_	24	conj	_	_
27	,	,	,	,	_	24	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	VCAM-1	vcam-1	NN	NN	_	24	conj	_	_
30	on	on	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	surface	surface	NN	NN	_	22	nmod	_	_
34	induced	induce	VBN	VBN	_	22	acl	_	_
35	by	by	IN	IN	_	37	case	_	_
36	monocyte	monocyte	NN	NN	_	37	compound	_	_
37	adhesion	adhesion	NN	NN	_	34	nmod	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	cross-linking	cross-linking	NN	NN	_	40	compound	_	_
40	antibodies	antibody	NNS	NNS	_	37	conj	_	_
41	.	.	.	.	_	8	punct	_	_

1	Similarly	similarly	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	N19RhoA	n19rhoa	NN	NN	_	4	nsubj	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	receptor	receptor	NN	NN	_	6	compound	_	_
6	clustering	clustering	NN	NN	_	4	dobj	_	_
7	.	.	.	.	_	4	punct	_	_

1	Monocyte	monocyte	NN	NN	_	2	compound	_	_
2	adhesion	adhesion	NN	NN	_	6	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	cross-linking	cross-linking	NN	NN	_	2	conj	_	_
6	induced	induced	JJ	JJ	_	0	root	_	_
7	stress	stress	NN	NN	_	9	compound	_	_
8	fiber	fiber	NN	NN	_	9	compound	_	_
9	assembly	assembly	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	inhibitors	inhibitor	NNS	NNS	_	18	nsubj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	myosin	myosin	NN	NN	_	17	compound	_	_
15	light	light	JJ	JJ	_	17	amod	_	_
16	chain	chain	NN	NN	_	17	compound	_	_
17	kinase	kinase	NN	NN	_	12	nmod	_	_
18	prevented	prevent	VBD	VBD	_	6	conj	_	_
19	this	this	DT	DT	_	20	det	_	_
20	response	response	NN	NN	_	18	dobj	_	_
21	but	but	CC	CC	_	18	cc	_	_
22	did	do	VBD	VBD	_	24	aux	_	_
23	not	not	RB	RB	_	24	neg	_	_
24	affect	affect	VB	VB	_	18	conj	_	_
25	receptor	receptor	NN	NN	_	26	compound	_	_
26	clustering	clustering	NN	NN	_	24	dobj	_	_
27	.	.	.	.	_	6	punct	_	_

1	Finally	finally	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	clusters	cluster	NNS	NNS	_	5	nsubj	_	_
5	colocalized	colocalize	VBD	VBD	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	ezrin/moesin/radixin	ezrin/moesin/radixin	NN	NN	_	8	compound	_	_
8	proteins	protein	NNS	NNS	_	5	nmod	_	_
9	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Rho	rho	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	endothelial	endothelial	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	assembly	assembly	NN	NN	_	7	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	stable	stable	JJ	JJ	_	16	amod	_	_
16	adhesions	adhesion	NNS	NNS	_	13	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
19	via	via	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	clustering	clustering	NN	NN	_	7	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	monocyte-binding	monocyte-binding	JJ	JJ	_	24	amod	_	_
24	receptors	receptor	NNS	NNS	_	21	nmod	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	their	they	PRP$	PRP$	_	27	nmod:poss	_	_
27	association	association	NN	NN	_	21	conj	_	_
28	with	with	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	actin	actin	NN	NN	_	31	compound	_	_
31	cytoskeleton	cytoskeleton	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	independent	independent	JJ	JJ	_	31	amod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	stress	stress	NN	NN	_	37	compound	_	_
36	fiber	fiber	NN	NN	_	37	compound	_	_
37	formation	formation	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Binding	binding	NN	NN	_	2	compound	_	_
2	characteristics	characteristic	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	glucocorticoid	glucocorticoid	NN	NN	_	6	compound	_	_
6	receptor	receptor	NN	NN	_	2	dep	_	_
7	in	in	IN	IN	_	10	case	_	_
8	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
9	blood	blood	NN	NN	_	10	compound	_	_
10	lymphocytes	lymphocyte	NNS	NNS	_	6	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	multiple	multiple	JJ	JJ	_	13	amod	_	_
13	sclerosis	sclerosis	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	11	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	exact	exact	JJ	JJ	_	4	amod	_	_
4	etiology	etiology	NN	NN	_	11	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	multiple	multiple	JJ	JJ	_	7	amod	_	_
7	sclerosis	sclerosis	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MS	ms	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	remains	remain	VBZ	VBZ	_	17	advcl	_	_
12	unresolved	unresolved	JJ	JJ	_	11	xcomp	_	_
13	,	,	,	,	_	17	punct	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	reactions	reaction	NNS	NNS	_	17	nsubjpass	_	_
16	are	be	VBP	VBP	_	17	auxpass	_	_
17	believed	believe	VBN	VBN	_	0	root	_	_
18	to	to	TO	TO	_	23	mark	_	_
19	be	be	VB	VB	_	23	cop	_	_
20	the	the	DT	DT	_	23	det	_	_
21	central	central	JJ	JJ	_	23	amod	_	_
22	pathogenic	pathogenic	JJ	JJ	_	23	amod	_	_
23	mechanisms	mechanism	NNS	NNS	_	17	xcomp	_	_
24	.	.	.	.	_	17	punct	_	_

1	Endogenous	endogenous	JJ	JJ	_	5	amod	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	therapeutic	therapeutic	JJ	JJ	_	1	conj	_	_
4	steroid	steroid	NN	NN	_	5	compound	_	_
5	hormones	hormone	NNS	NNS	_	6	nsubj	_	_
6	affect	affect	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	immune	immune	JJ	JJ	_	9	amod	_	_
9	system	system	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	6	punct	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	diseases	disease	NNS	NNS	_	15	nsubjpass	_	_
14	are	be	VBP	VBP	_	15	auxpass	_	_
15	associated	associate	VBN	VBN	_	6	conj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	21	amod	_	_
21	axis	axis	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	providing	provide	VBG	VBG	_	15	xcomp	_	_
24	evidence	evidence	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	an	a	DT	DT	_	28	det	_	_
27	immune-endocrine	immune-endocrine	JJ	JJ	_	28	amod	_	_
28	interplay	interplay	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	Function	function	NN	NN	_	2	compound	_	_
2	tests	test	NNS	NNS	_	6	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	MS	ms	NN	NN	_	2	nmod	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	revealed	reveal	VBN	VBN	_	0	root	_	_
7	dysregulation	dysregulation	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	hypothalamic-pituitary-adrenal	hypothalamic-pituitary-adrenal	JJ	JJ	_	11	amod	_	_
11	system	system	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	substantial	substantial	JJ	JJ	_	15	amod	_	_
15	proportion	proportion	NN	NN	_	7	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	characterized	characterize	VBD	VBD	_	0	root	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
4	receptor	receptor	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	GR	gr	NN	NN	_	8	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	binding	binding	NN	NN	_	2	dobj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	from	from	IN	IN	_	16	case	_	_
14	39	39	CD	CD	_	16	nummod	_	_
15	MS	ms	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	2	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	14	14	CD	CD	_	22	nummod	_	_
19	age-	age-	NN	NN	_	22	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	sex-matched	sex-matched	JJ	JJ	_	19	conj	_	_
22	controls	control	NNS	NNS	_	16	conj	_	_
23	with	with	IN	IN	_	24	case	_	_
24	respect	respect	NN	NN	_	2	nmod	_	_
25	to	to	TO	TO	_	27	case	_	_
26	dissociation	dissociation	NN	NN	_	27	compound	_	_
27	constant	constant	NN	NN	_	24	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	binding	binding	NN	NN	_	30	compound	_	_
30	capacity	capacity	NN	NN	_	27	conj	_	_
31	,	,	,	,	_	2	punct	_	_
32	using	use	VBG	VBG	_	2	advcl	_	_
33	a	a	DT	DT	_	36	det	_	_
34	whole-cell	whole-cell	JJ	JJ	_	36	amod	_	_
35	binding	binding	NN	NN	_	36	compound	_	_
36	assay	assay	NN	NN	_	32	dobj	_	_
37	with	with	IN	IN	_	38	case	_	_
38	-LSB-3H-RSB-dexamethasone	-lsb-3h-rsb-dexamethasone	NN	NN	_	36	nmod	_	_
39	as	as	IN	IN	_	41	case	_	_
40	the	the	DT	DT	_	41	det	_	_
41	ligand	ligand	NN	NN	_	38	nmod	_	_
42	.	.	.	.	_	2	punct	_	_

1	GR	gr	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	parameters	parameter	NNS	NNS	_	6	nsubj	_	_
4	did	do	VBD	VBD	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	differ	differ	VB	VB	_	0	root	_	_
7	significantly	significantly	RB	RB	_	6	advmod	_	_
8	between	between	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	6	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	Kd	kd	NN	NN	_	9	dep	_	_
12	8.98	8.98	CD	CD	_	11	nummod	_	_
13	+/-	+/-	CC	CC	_	11	cc	_	_
14	1.07	1.07	CD	CD	_	15	nummod	_	_
15	nM	nm	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	Bmax	bmax	NN	NN	_	11	appos	_	_
18	183	183	CD	CD	_	17	nummod	_	_
19	+/-	+/-	CC	CC	_	17	cc	_	_
20	29.8	29.8	CD	CD	_	21	nummod	_	_
21	fmol/mg	fmol/mg	NN	NN	_	17	conj	_	_
22	)	)	-RRB-	-RRB-	_	11	punct	_	_
23	and	and	CC	CC	_	9	cc	_	_
24	controls	control	NNS	NNS	_	9	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	Kd	kd	NN	NN	_	24	dep	_	_
27	9.36	9.36	CD	CD	_	26	nummod	_	_
28	+/-	+/-	CC	CC	_	26	cc	_	_
29	1.17	1.17	CD	CD	_	30	nummod	_	_
30	nM	nm	NN	NN	_	26	conj	_	_
31	,	,	,	,	_	26	punct	_	_
32	Bmax	bmax	NN	NN	_	26	appos	_	_
33	158	158	CD	CD	_	32	nummod	_	_
34	+/-	+/-	CC	CC	_	32	cc	_	_
35	16	16	CD	CD	_	36	nummod	_	_
36	fmol/mg	fmol/mg	NN	NN	_	32	conj	_	_
37	)	)	-RRB-	-RRB-	_	26	punct	_	_
38	.	.	.	.	_	6	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	effect	effect	NN	NN	_	21	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	age	age	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	sex	sex	NN	NN	_	4	conj	_	_
7	,	,	,	,	_	4	punct	_	_
8	course	course	NN	NN	_	4	conj	_	_
9	,	,	,	,	_	4	punct	_	_
10	duration	duration	NN	NN	_	4	conj	_	_
11	or	or	CC	CC	_	4	cc	_	_
12	severity	severity	NN	NN	_	4	conj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	disease	disease	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	or	or	CC	CC	_	4	cc	_	_
17	prior	prior	JJ	JJ	_	19	amod	_	_
18	steroid	steroid	NN	NN	_	19	compound	_	_
19	treatments	treatment	NNS	NNS	_	4	conj	_	_
20	was	be	VBD	VBD	_	21	auxpass	_	_
21	detected	detect	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	GR	gr	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	parameters	parameter	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	analyzed	analyze	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	relation	relation	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	results	result	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	combined	combined	JJ	JJ	_	15	amod	_	_
14	dexamethasone-CRH	dexamethasone-crh	JJ	JJ	_	15	amod	_	_
15	test	test	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	18	nsubj	_	_
18	reflects	reflect	VBZ	VBZ	_	15	acl:relcl	_	_
19	corticosteroid	corticosteroid	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	function	function	NN	NN	_	18	dobj	_	_
22	at	at	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	hypothalamus	hypothalamus	NN	NN	_	21	nmod	_	_
25	,	,	,	,	_	21	punct	_	_
26	in	in	IN	IN	_	28	case	_	_
27	30	30	CD	CD	_	28	nummod	_	_
28	patients	patient	NNS	NNS	_	21	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	9	9	CD	CD	_	31	nummod	_	_
31	controls	control	NNS	NNS	_	28	conj	_	_
32	.	.	.	.	_	5	punct	_	_

1	While	while	IN	IN	_	3	mark	_	_
2	controls	control	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	25	advcl	_	_
4	a	a	DT	DT	_	6	det	_	_
5	moderate	moderate	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	3	dobj	_	_
7	between	between	IN	IN	_	9	case	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	affinity	affinity	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	GR	gr	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	function	function	NN	NN	_	9	conj	_	_
18	at	at	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	hypothalamic	hypothalamic	JJ	JJ	_	21	amod	_	_
21	level	level	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	the	the	DT	DT	_	24	det	_	_
24	patients	patient	NNS	NNS	_	25	nsubj	_	_
25	did	do	VBD	VBD	_	0	root	_	_
26	not	not	RB	RB	_	25	neg	_	_
27	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	physiological	physiological	JJ	JJ	_	7	amod	_	_
7	relationship	relationship	NN	NN	_	17	nsubjpass	_	_
8	between	between	IN	IN	_	9	case	_	_
9	binding	binding	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	function	function	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	receptor	receptor	NN	NN	_	9	nmod	_	_
16	is	be	VBZ	VBZ	_	17	auxpass	_	_
17	disturbed	disturb	VBN	VBN	_	3	ccomp	_	_
18	in	in	IN	IN	_	19	case	_	_
19	MS	ms	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	CBP/p300	cbp/p300	NN	NN	_	2	nsubj	_	_
2	integrates	integrate	VBZ	VBZ	_	0	root	_	_
3	Raf/Rac-signaling	raf/rac-signaling	JJ	JJ	_	4	amod	_	_
4	pathways	pathway	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	induction	induction	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	NF-ATc	nf-atc	NN	NN	_	8	nmod	_	_
11	during	during	IN	IN	_	14	case	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	8	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	NF-ATc	nf-atc	NN	NN	_	9	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	an	a	DT	DT	_	7	det	_	_
4	inducibly	inducibly	RB	RB	_	5	advmod	_	_
5	expressed	express	VBN	VBN	_	7	amod	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	9	punct	_	_
9	controls	control	VBZ	VBZ	_	0	root	_	_
10	gene	gene	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	cardiomyocytes	cardiomyocyte	NNS	NNS	_	14	conj	_	_
17	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	here	here	RB	RB	_	2	advmod	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	transcriptional	transcriptional	JJ	JJ	_	7	amod	_	_
7	co-activators	co-activator	NNS	NNS	_	9	nsubj	_	_
8	CBP/p300	cbp/p300	NN	NN	_	7	dep	_	_
9	bind	bind	VBP	VBP	_	2	ccomp	_	_
10	to	to	TO	TO	_	9	nmod	_	_
11	and	and	CC	CC	_	9	cc	_	_
12	control	control	VBP	VBP	_	9	conj	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	9	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	inducible	inducible	JJ	JJ	_	20	amod	_	_
18	N-terminal	n-terminal	JJ	JJ	_	20	amod	_	_
19	transactivation	transactivation	NN	NN	_	20	compound	_	_
20	domain	domain	NN	NN	_	14	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	NF-ATc	nf-atc	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	TAD-A	tad-a	NN	NN	_	22	appos	_	_
25	.	.	.	.	_	2	punct	_	_

1	Similar	similar	JJ	JJ	_	0	root	_	_
2	to	to	TO	TO	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	N	n	NN	NN	_	7	compound	_	_
5	terminal	terminal	JJ	JJ	_	7	amod	_	_
6	transactivation	transactivation	NN	NN	_	7	compound	_	_
7	domain	domain	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	c-Jun	c-jun	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	1	punct	_	_
11	TAD-A	tad-a	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	inducibly	inducibly	RB	RB	_	14	advmod	_	_
14	phosphorylated	phosphorylate	VBN	VBN	_	1	ccomp	_	_
15	,	,	,	,	_	1	punct	_	_
16	but	but	CC	CC	_	1	cc	_	_
17	this	this	DT	DT	_	18	det	_	_
18	phosphorylation	phosphorylation	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	dispensable	dispensable	JJ	JJ	_	1	conj	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	interaction	interaction	NN	NN	_	20	nmod	_	_
24	with	with	IN	IN	_	25	case	_	_
25	CBP/p300	cbp/p300	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	1	punct	_	_

1	Constitutive	constitutive	JJ	JJ	_	3	amod	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	versions	version	NNS	NNS	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	c-Raf	c-raf	NN	NN	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	Rac	rac	NN	NN	_	5	conj	_	_
8	synergistically	synergistically	RB	RB	_	9	advmod	_	_
9	enhance	enhance	VBP	VBP	_	0	root	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CBP/p300-mediated	cbp/p300-mediated	JJ	JJ	_	12	amod	_	_
12	increase	increase	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	TAD-A	tad-a	NN	NN	_	15	compound	_	_
15	activity	activity	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	indicating	indicate	VBG	VBG	_	9	advcl	_	_
18	the	the	DT	DT	_	20	det	_	_
19	important	important	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	17	dobj	_	_
21	CBP/p300	cbp/p300	NN	NN	_	22	nsubj	_	_
22	plays	play	VBZ	VBZ	_	20	acl:relcl	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	integration	integration	NN	NN	_	22	nmod	_	_
26	of	of	IN	IN	_	30	case	_	_
27	T	t	NN	NN	_	30	compound	_	_
28	cell	cell	NN	NN	_	30	compound	_	_
29	activation	activation	NN	NN	_	30	compound	_	_
30	signals	signal	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	12	mark	_	_
2	a	a	DT	DT	_	3	det	_	_
3	mutation	mutation	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	CBP	cbp	NN	NN	_	8	compound	_	_
6	abolishing	abolish	VBG	VBG	_	8	amod	_	_
7	HAT	hat	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	almost	almost	RB	RB	_	12	advmod	_	_
11	as	as	RB	RB	_	12	advmod	_	_
12	active	active	JJ	JJ	_	27	advcl	_	_
13	as	as	IN	IN	_	15	case	_	_
14	wild-type	wild-type	JJ	JJ	_	15	amod	_	_
15	CBP	cbp	NN	NN	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	27	punct	_	_
20	functions	function	NNS	NNS	_	27	nsubj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	CBP/p300	cbp/p300	NN	NN	_	20	nmod	_	_
23	other	other	JJ	JJ	_	22	cc	_	_
24	than	than	IN	IN	_	23	dep	_	_
25	histone	histone	NN	NN	_	26	compound	_	_
26	acetylation	acetylation	NN	NN	_	22	conj	_	_
27	appear	appear	VBP	VBP	_	0	root	_	_
28	to	to	TO	TO	_	29	mark	_	_
29	control	control	VB	VB	_	27	xcomp	_	_
30	the	the	DT	DT	_	32	det	_	_
31	NF-AT-dependent	nf-at-dependent	JJ	JJ	_	32	amod	_	_
32	transcription	transcription	NN	NN	_	29	dobj	_	_
33	in	in	IN	IN	_	35	case	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	27	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	polymorphism	polymorphism	NN	NN	_	13	nsubjpass	_	_
3	that	that	WDT	WDT	_	4	nsubj	_	_
4	affects	affect	VBZ	VBZ	_	2	acl:relcl	_	_
5	OCT-1	oct-1	NN	NN	_	6	compound	_	_
6	binding	binding	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	TNF	tnf	NN	NN	_	11	compound	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	region	region	NN	NN	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	associated	associate	VBN	VBN	_	0	root	_	_
14	with	with	IN	IN	_	16	case	_	_
15	severe	severe	JJ	JJ	_	16	amod	_	_
16	malaria	malaria	NN	NN	_	13	nmod	_	_
17	-LSB-	-lsb-	-LRB-	-LRB-	_	18	punct	_	_
18	see	see	VB	VB	_	13	parataxis	_	_
19	comments	comment	NNS	NNS	_	18	dobj	_	_
20	-RSB-	-rsb-	-RRB-	-RRB-	_	18	punct	_	_

1	Genetic	genetic	JJ	JJ	_	2	amod	_	_
2	variation	variation	NN	NN	_	8	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	cytokine	cytokine	NN	NN	_	6	compound	_	_
5	promoter	promoter	NN	NN	_	6	compound	_	_
6	regions	region	NNS	NNS	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	postulated	postulate	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	influence	influence	VB	VB	_	8	xcomp	_	_
11	susceptibility	susceptibility	NN	NN	_	10	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	infection	infection	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	8	punct	_	_
15	but	but	CC	CC	_	8	cc	_	_
16	the	the	DT	DT	_	18	det	_	_
17	molecular	molecular	JJ	JJ	_	18	amod	_	_
18	mechanisms	mechanism	NNS	NNS	_	28	nsubj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	24	nmod	_	_
21	such	such	JJ	JJ	_	22	amod	_	_
22	polymorphisms	polymorphism	NNS	NNS	_	24	nsubj	_	_
23	might	might	MD	MD	_	24	aux	_	_
24	affect	affect	VB	VB	_	18	acl:relcl	_	_
25	gene	gene	NN	NN	_	26	compound	_	_
26	regulation	regulation	NN	NN	_	24	dobj	_	_
27	are	be	VBP	VBP	_	28	aux	_	_
28	unknown	unknown	JJ	JJ	_	8	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	Through	through	IN	IN	_	4	case	_	_
2	systematic	systematic	JJ	JJ	_	4	amod	_	_
3	DNA	dna	NN	NN	_	4	compound	_	_
4	footprinting	footprinting	NN	NN	_	21	nmod	_	_
5	of	of	IN	IN	_	17	case	_	_
6	the	the	DT	DT	_	17	det	_	_
7	TNF	tnf	NN	NN	_	17	compound	_	_
8	(	(	-LRB-	-LRB-	_	12	punct	_	_
9	encoding	encode	VBG	VBG	_	12	amod	_	_
10	tumour	tumour	NN	NN	_	12	compound	_	_
11	necrosis	necrosis	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	17	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	TNF	tnf	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	region	region	NN	NN	_	4	nmod	_	_
18	,	,	,	,	_	21	punct	_	_
19	we	we	PRP	PRP	_	21	nsubj	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	identified	identify	VBN	VBN	_	0	root	_	_
22	a	a	DT	DT	_	25	det	_	_
23	single	single	JJ	JJ	_	25	amod	_	_
24	nucleotide	nucleotide	NN	NN	_	25	compound	_	_
25	polymorphism	polymorphism	NN	NN	_	21	dobj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	SNP	snp	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	causes	cause	VBZ	VBZ	_	25	acl:relcl	_	_
31	the	the	DT	DT	_	35	det	_	_
32	helix-turn-helix	helix-turn-helix	JJ	JJ	_	35	amod	_	_
33	transcription	transcription	NN	NN	_	35	compound	_	_
34	factor	factor	NN	NN	_	35	compound	_	_
35	OCT-1	oct-1	NN	NN	_	30	dobj	_	_
36	to	to	TO	TO	_	37	mark	_	_
37	bind	bind	VB	VB	_	30	xcomp	_	_
38	to	to	TO	TO	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	novel	novel	JJ	JJ	_	41	amod	_	_
41	region	region	NN	NN	_	37	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	complex	complex	JJ	JJ	_	45	amod	_	_
44	protein-DNA	protein-dna	JJ	JJ	_	45	amod	_	_
45	interactions	interaction	NNS	NNS	_	41	nmod	_	_
46	and	and	CC	CC	_	30	cc	_	_
47	alters	alter	VBZ	VBZ	_	30	conj	_	_
48	gene	gene	NN	NN	_	49	compound	_	_
49	expression	expression	NN	NN	_	47	dobj	_	_
50	in	in	IN	IN	_	52	case	_	_
51	human	human	JJ	JJ	_	52	amod	_	_
52	monocytes	monocyte	NNS	NNS	_	49	nmod	_	_
53	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	OCT-1-binding	oct-1-binding	JJ	JJ	_	3	amod	_	_
3	genotype	genotype	NN	NN	_	14	nsubjpass	_	_
4	,	,	,	,	_	3	punct	_	_
5	found	find	VBD	VBD	_	3	acl	_	_
6	in	in	IN	IN	_	9	case	_	_
7	approximately	approximately	RB	RB	_	8	advmod	_	_
8	5	5	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Africans	african	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	associated	associate	VBN	VBN	_	0	root	_	_
15	with	with	IN	IN	_	18	case	_	_
16	fourfold	fourfold	RB	RB	_	17	advmod	_	_
17	increased	increase	VBN	VBN	_	18	amod	_	_
18	susceptibility	susceptibility	NN	NN	_	14	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	cerebral	cerebral	JJ	JJ	_	21	amod	_	_
21	malaria	malaria	NN	NN	_	18	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	large	large	JJ	JJ	_	25	amod	_	_
24	case-control	case-control	JJ	JJ	_	25	amod	_	_
25	studies	study	NNS	NNS	_	14	nmod	_	_
26	of	of	IN	IN	_	32	case	_	_
27	West	west	JJ	JJ	_	28	amod	_	_
28	African	african	JJ	JJ	_	32	amod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	East	east	JJ	JJ	_	31	amod	_	_
31	African	african	JJ	JJ	_	28	conj	_	_
32	populations	population	NNS	NNS	_	25	nmod	_	_
33	,	,	,	,	_	25	punct	_	_
34	after	after	IN	IN	_	35	case	_	_
35	correction	correction	NN	NN	_	25	nmod	_	_
36	for	for	IN	IN	_	40	case	_	_
37	other	other	JJ	JJ	_	40	amod	_	_
38	known	known	JJ	JJ	_	40	amod	_	_
39	TNF	tnf	NN	NN	_	40	compound	_	_
40	polymorphisms	polymorphism	NNS	NNS	_	35	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	linked	link	VBN	VBN	_	44	amod	_	_
43	HLA	hla	NN	NN	_	44	compound	_	_
44	alleles	allele	NNS	NNS	_	40	conj	_	_
45	.	.	.	.	_	14	punct	_	_

1	Association	association	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	interleukin-4	interleukin-4	NN	NN	_	7	compound	_	_
5	receptor	receptor	NN	NN	_	7	compound	_	_
6	alpha	alpha	NN	NN	_	7	compound	_	_
7	chain	chain	NN	NN	_	1	nmod	_	_
8	with	with	IN	IN	_	9	case	_	_
9	p47phox	p47phox	NN	NN	_	1	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	an	a	DT	DT	_	12	det	_	_
12	activator	activator	NN	NN	_	9	appos	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	phagocyte	phagocyte	NN	NN	_	17	compound	_	_
16	NADPH	nadph	NN	NN	_	17	compound	_	_
17	oxidase	oxidase	NN	NN	_	12	nmod	_	_
18	in	in	IN	IN	_	20	case	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	Interleukin	interleukin	NN	NN	_	6	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IL	il	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	-4	-4	CD	CD	_	1	nummod	_	_
6	plays	play	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	important	important	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	IgE	ige	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	9	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	in	in	IN	IN	_	19	case	_	_
18	Th2	th2	NN	NN	_	19	compound	_	_
19	differentiation	differentiation	NN	NN	_	12	conj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	6	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	conducts	conduct	VBZ	VBZ	_	0	root	_	_
3	its	its	PRP$	PRP$	_	5	nmod:poss	_	_
4	biological	biological	JJ	JJ	_	5	amod	_	_
5	activities	activity	NNS	NNS	_	2	dobj	_	_
6	through	through	IN	IN	_	7	mark	_	_
7	binding	bind	VBG	VBG	_	2	advcl	_	_
8	to	to	TO	TO	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	IL-4	il-4	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IL-4R	il-4r	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	on	on	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	surface	surface	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	target	target	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	IL-4R	il-4r	NN	NN	_	3	nsubjpass	_	_
2	are	be	VBP	VBP	_	3	auxpass	_	_
3	thought	think	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	mark	_	_
5	be	be	VB	VB	_	6	auxpass	_	_
6	composed	compose	VBN	VBN	_	3	xcomp	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	IL-4R	il-4r	NN	NN	_	11	compound	_	_
10	alpha	alpha	NN	NN	_	11	compound	_	_
11	chain	chain	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	14	punct	_	_
13	IL-4R	il-4r	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	either	either	CC	CC	_	21	cc:preconj	_	_
18	the	the	DT	DT	_	21	det	_	_
19	IL-2R	il-2r	NN	NN	_	21	compound	_	_
20	gamma	gamma	NN	NN	_	21	compound	_	_
21	chain	chain	NN	NN	_	11	conj	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	IL-13R	il-13r	NN	NN	_	26	compound	_	_
25	alpha	alpha	NN	NN	_	26	compound	_	_
26	chain	chain	NN	NN	_	21	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	previously	previously	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	23	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	membrane-proximal	membrane-proximal	JJ	JJ	_	8	amod	_	_
8	portion	portion	NN	NN	_	23	nsubj	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	cytoplasmic	cytoplasmic	JJ	JJ	_	12	amod	_	_
12	domain	domain	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	IL-4R	il-4r	NN	NN	_	17	compound	_	_
17	alpha	alpha	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	20	punct	_	_
19	hIL-4R	hil-4r	NN	NN	_	20	compound	_	_
20	alpha	alpha	NN	NN	_	17	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	critical	critical	JJ	JJ	_	4	ccomp	_	_
24	for	for	IN	IN	_	25	case	_	_
25	proliferation	proliferation	NN	NN	_	23	nmod	_	_
26	,	,	,	,	_	25	punct	_	_
27	generation	generation	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	germline	germline	NN	NN	_	31	compound	_	_
30	epsilon	epsilon	NN	NN	_	31	compound	_	_
31	transcript	transcript	NN	NN	_	27	nmod	_	_
32	,	,	,	,	_	25	punct	_	_
33	and	and	CC	CC	_	25	cc	_	_
34	activation	activation	NN	NN	_	25	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	STAT6	stat6	NN	NN	_	34	nmod	_	_
37	,	,	,	,	_	23	punct	_	_
38	based	base	VBN	VBN	_	40	case	_	_
39	on	on	IN	IN	_	40	case	_	_
40	analyses	analysis	NNS	NNS	_	23	advcl	_	_
41	of	of	IN	IN	_	44	case	_	_
42	truncated	truncate	VBN	VBN	_	44	amod	_	_
43	hIL-4R	hil-4r	NN	NN	_	44	compound	_	_
44	alphas	alpha	NNS	NNS	_	40	nmod	_	_
45	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	found	find	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	18	mark	_	_
8	p47phox	p47phox	NN	NN	_	18	nsubj	_	_
9	,	,	,	,	_	8	punct	_	_
10	an	a	DT	DT	_	11	det	_	_
11	activator	activator	NN	NN	_	8	appos	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	phagocyte	phagocyte	NN	NN	_	16	compound	_	_
15	NADPH	nadph	NN	NN	_	16	compound	_	_
16	oxidase	oxidase	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	18	punct	_	_
18	binds	bind	VBZ	VBZ	_	6	ccomp	_	_
19	to	to	TO	TO	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	portion	portion	NN	NN	_	18	nmod	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	two-hybrid	two-hybrid	JJ	JJ	_	25	amod	_	_
25	system	system	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	6	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	observed	observe	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	association	association	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p47phox	p47phox	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	hIL-4R	hil-4r	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	derived	derive	VBN	VBN	_	15	acl	_	_
17	from	from	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	normal	normal	JJ	JJ	_	20	amod	_	_
20	donor	donor	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	p47phox	p47phox	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	involved	involve	VBN	VBN	_	3	ccomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	IL-4	il-4	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	activation	activation	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	STAT6	stat6	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	CD23	cd23	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	3	conj	_	_
9	,	,	,	,	_	3	punct	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	IgE	ige	NN	NN	_	12	compound	_	_
12	synthesis	synthesis	NN	NN	_	3	conj	_	_
13	induced	induce	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	IL-4	il-4	NN	NN	_	13	nmod	_	_
16	were	be	VBD	VBD	_	18	auxpass	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	affected	affect	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	21	case	_	_
20	p47phox-deficient	p47phox-deficient	JJ	JJ	_	21	amod	_	_
21	patients	patient	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	which	which	WDT	WDT	_	24	nsubj	_	_
24	raises	raise	VBZ	VBZ	_	18	ccomp	_	_
25	the	the	DT	DT	_	26	det	_	_
26	possibility	possibility	NN	NN	_	24	dobj	_	_
27	that	that	IN	IN	_	31	mark	_	_
28	p47phox	p47phox	NN	NN	_	31	nsubj	_	_
29	may	may	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	cop	_	_
31	important	important	JJ	JJ	_	26	dep	_	_
32	in	in	IN	IN	_	35	case	_	_
33	other	other	JJ	JJ	_	35	amod	_	_
34	signaling	signaling	NN	NN	_	35	compound	_	_
35	activities	activity	NNS	NNS	_	31	nmod	_	_
36	as	as	RB	RB	_	35	cc	_	_
37	well	well	RB	RB	_	36	mwe	_	_
38	in	in	IN	IN	_	40	case	_	_
39	B	b	NN	NN	_	40	compound	_	_
40	cells	cell	NNS	NNS	_	35	conj	_	_
41	.	.	.	.	_	18	punct	_	_

1	Aiolos	aiolos	NN	NN	_	4	nsubj	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	1	dep	_	_
4	controls	control	VBZ	VBZ	_	0	root	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	death	death	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	regulating	regulate	VBG	VBG	_	4	advcl	_	_
12	Bcl-2	bcl-2	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	cellular	cellular	JJ	JJ	_	17	amod	_	_
17	localization	localization	NN	NN	_	13	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	searched	search	VBD	VBD	_	0	root	_	_
3	for	for	IN	IN	_	4	case	_	_
4	proteins	protein	NNS	NNS	_	2	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	interact	interact	VBP	VBP	_	4	acl:relcl	_	_
7	with	with	IN	IN	_	8	case	_	_
8	Ras	ras	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	17	case	_	_
10	interleukin	interleukin	NN	NN	_	14	nmod:npmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	IL	il	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	-2-stimulated	-2-stimulated	JJ	JJ	_	17	amod	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	IL-2-deprived	il-2-deprived	JJ	JJ	_	14	conj	_	_
17	cells	cell	NNS	NNS	_	8	nmod	_	_
18	,	,	,	,	_	2	punct	_	_
19	and	and	CC	CC	_	2	cc	_	_
20	found	find	VBD	VBD	_	2	conj	_	_
21	that	that	IN	IN	_	26	mark	_	_
22	the	the	DT	DT	_	24	det	_	_
23	transcription	transcription	NN	NN	_	24	compound	_	_
24	factor	factor	NN	NN	_	26	nsubj	_	_
25	Aiolos	aiolos	NN	NN	_	24	dep	_	_
26	interacts	interact	VBZ	VBZ	_	20	ccomp	_	_
27	with	with	IN	IN	_	28	case	_	_
28	Ras	ras	NN	NN	_	26	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Ras-Aiolos	ras-aiolos	NN	NN	_	3	compound	_	_
3	interaction	interaction	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	confirmed	confirm	VBN	VBN	_	0	root	_	_
6	in	in	FW	FW	_	7	compound	_	_
7	vitro	vitro	FW	FW	_	8	advmod	_	_
8	and	and	CC	CC	_	5	advmod	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vivo	vivo	FW	FW	_	8	advmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	co-immunoprecipitation	co-immunoprecipitation	NN	NN	_	5	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Indirect	indirect	JJ	JJ	_	2	amod	_	_
2	immunofluorescence	immunofluorescence	NN	NN	_	3	nsubj	_	_
3	shows	show	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IL-2	il-2	NN	NN	_	6	nsubj	_	_
6	controls	control	VBZ	VBZ	_	3	ccomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	cellular	cellular	JJ	JJ	_	9	amod	_	_
9	distribution	distribution	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Aiolos	aiolos	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	6	cc	_	_
13	induces	induce	VBZ	VBZ	_	6	conj	_	_
14	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	required	require	VBN	VBN	_	16	acl	_	_
19	for	for	IN	IN	_	20	case	_	_
20	dissociation	dissociation	NN	NN	_	18	nmod	_	_
21	from	from	IN	IN	_	22	case	_	_
22	Ras	ras	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	identified	identify	VBD	VBD	_	0	root	_	_
4	functional	functional	JJ	JJ	_	6	amod	_	_
5	Aiolos-binding	aiolos-binding	JJ	JJ	_	6	amod	_	_
6	sites	site	NNS	NNS	_	3	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	Bcl-2	bcl-2	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	which	which	WDT	WDT	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	able	able	JJ	JJ	_	6	acl:relcl	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	activate	activate	VB	VB	_	14	xcomp	_	_
17	the	the	DT	DT	_	20	det	_	_
18	luciferase	luciferase	NN	NN	_	20	compound	_	_
19	reporter	reporter	NN	NN	_	20	compound	_	_
20	gene	gene	NN	NN	_	16	dobj	_	_
21	.	.	.	.	_	3	punct	_	_

1	Mutation	mutation	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	Aiolos-binding	aiolos-binding	JJ	JJ	_	4	amod	_	_
4	sites	site	NNS	NNS	_	1	nmod	_	_
5	within	within	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Bcl-2	bcl-2	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
10	transactivation	transactivation	NN	NN	_	9	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	reporter	reporter	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	luciferase	luciferase	NN	NN	_	10	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	suggesting	suggest	VBG	VBG	_	9	advcl	_	_
18	direct	direct	JJ	JJ	_	19	amod	_	_
19	control	control	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	Bcl-2	bcl-2	NN	NN	_	22	compound	_	_
22	expression	expression	NN	NN	_	19	nmod	_	_
23	by	by	IN	IN	_	24	case	_	_
24	Aiolos	aiolos	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	Co-transfection	co-transfection	NN	NN	_	2	compound	_	_
2	experiments	experiment	NNS	NNS	_	3	nsubj	_	_
3	confirm	confirm	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	Aiolos	aiolos	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	Bcl-2	bcl-2	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	prevents	prevent	VBZ	VBZ	_	6	conj	_	_
11	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	IL-2-deprived	il-2-deprived	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	a	a	DT	DT	_	4	det	_	_
4	model	model	NN	NN	_	2	dobj	_	_
5	for	for	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	regulation	regulation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	Bcl-2	bcl-2	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	via	via	IN	IN	_	12	case	_	_
12	Aiolos	aiolos	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	0	root	_	_
3	in	in	IN	IN	_	5	case	_	_
4	rheumatoid	rheumatoid	JJ	JJ	_	5	amod	_	_
5	arthritis	arthritis	NN	NN	_	2	nmod	_	_
6	:	:	:	:	_	2	punct	_	_
7	correlation	correlation	NN	NN	_	2	dep	_	_
8	with	with	IN	IN	_	9	case	_	_
9	inflammation	inflammation	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	disease	disease	NN	NN	_	13	compound	_	_
13	specificity	specificity	NN	NN	_	9	appos	_	_
14	.	.	.	.	_	2	punct	_	_

1	Rheumatoid	rheumatoid	JJ	JJ	_	4	amod	_	_
2	arthritis	arthritis	NN	NN	_	4	compound	_	_
3	synovial	synovial	JJ	JJ	_	4	amod	_	_
4	tissue	tissue	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	examined	examine	VBN	VBN	_	0	root	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	compared	compare	VBN	VBN	_	6	conj	_	_
9	with	with	IN	IN	_	11	case	_	_
10	osteoarthritis	osteoarthritis	NN	NN	_	11	compound	_	_
11	tissue	tissue	NN	NN	_	8	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	8	nmod	_	_
15	of	of	IN	IN	_	23	case	_	_
16	the	the	DT	DT	_	23	det	_	_
17	nuclear	nuclear	JJ	JJ	_	23	amod	_	_
18	transcription	transcription	NN	NN	_	23	compound	_	_
19	factor	factor	NN	NN	_	23	compound	_	_
20	C/EBP	c/ebp	NN	NN	_	23	compound	_	_
21	beta	beta	NN	NN	_	23	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NF-IL-6	nf-il-6	NN	NN	_	14	nmod	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	region	region	NN	NN	_	27	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	lining	lining	JJ	JJ	_	2	dep	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	sublining	sublining	JJ	JJ	_	4	conj	_	_
7	)	)	-RRB-	-RRB-	_	4	punct	_	_
8	,	,	,	,	_	2	punct	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	type	type	NN	NN	_	2	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	and	and	CC	CC	_	2	cc	_	_
13	subcellular	subcellular	JJ	JJ	_	14	amod	_	_
14	distribution	distribution	NN	NN	_	2	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	cytoplasmic	cytoplasmic	JJ	JJ	_	14	dep	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	nuclear	nuclear	JJ	JJ	_	16	conj	_	_
19	)	)	-RRB-	-RRB-	_	16	punct	_	_
20	of	of	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	2	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	C/EBP	c/ebp	NN	NN	_	25	compound	_	_
25	beta	beta	NN	NN	_	22	nmod	_	_
26	was	be	VBD	VBD	_	27	auxpass	_	_
27	characterized	characterize	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	Rheumatoid	rheumatoid	JJ	JJ	_	2	amod	_	_
2	arthritis	arthritis	NN	NN	_	13	nsubjpass	_	_
3	synovial	synovial	JJ	JJ	_	4	amod	_	_
4	fluid	fluid	NN	NN	_	2	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	blood	blood	NN	NN	_	4	conj	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	normal	normal	JJ	JJ	_	10	amod	_	_
9	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
10	blood	blood	NN	NN	_	2	conj	_	_
11	were	be	VBD	VBD	_	13	auxpass	_	_
12	also	also	RB	RB	_	13	advmod	_	_
13	examined	examine	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	C/EBP	c/ebp	NN	NN	_	2	compound	_	_
2	beta	beta	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	synovial	synovial	JJ	JJ	_	8	amod	_	_
8	lining	lining	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	in	in	IN	IN	_	15	case	_	_
11	sublining	sublining	JJ	JJ	_	15	amod	_	_
12	cells	cell	NNS	NNS	_	15	compound	_	_
13	of	of	IN	IN	_	15	amod	_	_
14	synovial	synovial	JJ	JJ	_	15	amod	_	_
15	tissue	tissue	NN	NN	_	8	conj	_	_
16	from	from	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	rheumatoid	rheumatoid	JJ	JJ	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	osteoarthritis	osteoarthritis	NN	NN	_	20	conj	_	_
23	.	.	.	.	_	4	punct	_	_

1	A	a	DT	DT	_	13	det	_	_
2	significant	significant	JJ	JJ	_	13	amod	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	P	p	NN	NN	_	6	nsubj	_	_
5	&lt;	&lt;	JJR	JJR	_	6	dep	_	_
6	0.001	0.001	CD	CD	_	13	dep	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	&lt;	&lt;	JJR	JJR	_	9	dep	_	_
9	0.05	0.05	CD	CD	_	6	conj	_	_
10	,	,	,	,	_	6	punct	_	_
11	respectively	respectively	RB	RB	_	6	advmod	_	_
12	)	)	-RRB-	-RRB-	_	6	punct	_	_
13	increase	increase	NN	NN	_	23	nsubjpass	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	percentage	percentage	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	cells	cell	NNS	NNS	_	16	nmod	_	_
19	with	with	IN	IN	_	21	case	_	_
20	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
21	staining	staining	NN	NN	_	18	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	seen	see	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	lining	lining	JJ	JJ	_	27	amod	_	_
27	layer	layer	NN	NN	_	23	nmod	_	_
28	,	,	,	,	_	23	punct	_	_
29	compared	compare	VBN	VBN	_	31	case	_	_
30	to	to	TO	TO	_	31	case	_	_
31	cells	cell	NNS	NNS	_	23	advcl	_	_
32	in	in	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	sublining	sublining	JJ	JJ	_	35	amod	_	_
35	region	region	NN	NN	_	31	nmod	_	_
36	,	,	,	,	_	31	punct	_	_
37	in	in	IN	IN	_	38	case	_	_
38	rheumatoid	rheumatoid	NN	NN	_	31	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	osteoarthritis	osteoarthritis	NN	NN	_	38	conj	_	_
41	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	both	both	DT	DT	_	3	det	_	_
3	diseases	disease	NNS	NNS	_	17	nmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	strong	strong	JJ	JJ	_	6	amod	_	_
6	correlation	correlation	NN	NN	_	17	nsubjpass	_	_
7	(	(	-LRB-	-LRB-	_	9	punct	_	_
8	r	r	NN	NN	_	9	nsubj	_	_
9	=	=	JJ	JJ	_	6	dep	_	_
10	0.79	0.79	CD	CD	_	9	dobj	_	_
11	,	,	,	,	_	9	punct	_	_
12	P	p	NN	NN	_	14	nsubj	_	_
13	&lt;	&lt;	JJR	JJR	_	14	dep	_	_
14	0.001	0.001	CD	CD	_	9	parataxis	_	_
15	)	)	-RRB-	-RRB-	_	9	punct	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	observed	observe	VBN	VBN	_	0	root	_	_
18	between	between	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	percentage	percentage	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	cells	cell	NNS	NNS	_	20	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	synovial	synovial	JJ	JJ	_	26	amod	_	_
26	lining	lining	NN	NN	_	22	nmod	_	_
27	that	that	WDT	WDT	_	29	nsubj	_	_
28	were	be	VBD	VBD	_	29	cop	_	_
29	positive	positive	JJ	JJ	_	22	acl:relcl	_	_
30	for	for	IN	IN	_	33	case	_	_
31	nuclear	nuclear	JJ	JJ	_	33	amod	_	_
32	C/EBP	c/ebp	NN	NN	_	33	compound	_	_
33	beta	beta	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	20	cc	_	_
35	lining	lining	JJ	JJ	_	37	amod	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	depth	depth	NN	NN	_	20	conj	_	_
38	.	.	.	.	_	17	punct	_	_

1	Two-color	two-color	JJ	JJ	_	2	amod	_	_
2	immunohistochemistry	immunohistochemistry	NN	NN	_	3	nsubj	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	both	both	CC	CC	_	6	cc:preconj	_	_
6	macrophages	macrophage	NNS	NNS	_	11	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	fibroblast-like	fibroblast-like	JJ	JJ	_	9	amod	_	_
9	synoviocytes	synoviocyte	NNS	NNS	_	6	conj	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	positive	positive	JJ	JJ	_	3	ccomp	_	_
12	for	for	IN	IN	_	15	case	_	_
13	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
14	C/EBP	c/ebp	NN	NN	_	15	compound	_	_
15	beta	beta	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	presence	presence	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	C/EBP	c/ebp	NN	NN	_	5	compound	_	_
5	beta	beta	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	immunohistochemistry	immunohistochemistry	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Western	western	NN	NN	_	13	compound	_	_
12	blot	blot	NN	NN	_	13	compound	_	_
13	analysis	analysis	NN	NN	_	9	conj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	isolated	isolate	VBN	VBN	_	17	amod	_	_
16	synovial	synovial	JJ	JJ	_	17	amod	_	_
17	fibroblasts	fibroblast	NNS	NNS	_	9	nmod	_	_
18	.	.	.	.	_	7	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	C/EBP	c/ebp	NN	NN	_	3	compound	_	_
3	beta	beta	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	rheumatoid	rheumatoid	JJ	JJ	_	10	amod	_	_
9	synovial	synovial	JJ	JJ	_	10	amod	_	_
10	fluid	fluid	NN	NN	_	6	nmod	_	_
11	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	10	dep	_	_
12	,	,	,	,	_	10	punct	_	_
13	but	but	CC	CC	_	10	cc	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	in	in	IN	IN	_	16	case	_	_
16	lymphocytes	lymphocyte	NNS	NNS	_	10	conj	_	_
17	or	or	CC	CC	_	16	cc	_	_
18	neutrophils	neutrophil	NNS	NNS	_	16	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	Western	western	NN	NN	_	3	compound	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	confirmed	confirm	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	presence	presence	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	C/EBP	c/ebp	NN	NN	_	9	compound	_	_
9	beta	beta	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	intensity	intensity	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	C/EBP	c/ebp	NN	NN	_	6	compound	_	_
5	beta	beta	NN	NN	_	6	compound	_	_
6	staining	staining	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	greater	greater	JJR	JJR	_	0	root	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	P	p	NN	NN	_	12	nsubj	_	_
11	&lt;	&lt;	JJR	JJR	_	12	dep	_	_
12	0.001	0.001	CD	CD	_	8	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	17	case	_	_
15	synovial	synovial	JJ	JJ	_	17	amod	_	_
16	fluid	fluid	NN	NN	_	17	compound	_	_
17	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
18	than	than	IN	IN	_	17	cc	_	_
19	in	in	IN	IN	_	20	case	_	_
20	those	those	DT	DT	_	17	conj	_	_
21	from	from	IN	IN	_	26	case	_	_
22	normal	normal	JJ	JJ	_	26	amod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	rheumatoid	rheumatoid	JJ	JJ	_	22	conj	_	_
25	peripheral	peripheral	JJ	JJ	_	26	amod	_	_
26	blood	blood	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	49	nmod	_	_
3	,	,	,	,	_	49	punct	_	_
4	the	the	DT	DT	_	7	det	_	_
5	enhanced	enhance	VBN	VBN	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	staining	staining	NN	NN	_	49	nsubj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	C/EBP	c/ebp	NN	NN	_	10	compound	_	_
10	beta	beta	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	synovial	synovial	JJ	JJ	_	14	amod	_	_
14	lining	lining	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	7	punct	_	_
16	compared	compare	VBN	VBN	_	7	acl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	sublining	sublining	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	16	punct	_	_
21	suggesting	suggest	VBG	VBG	_	16	xcomp	_	_
22	activation	activation	NN	NN	_	21	dobj	_	_
23	in	in	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	lining	lining	NN	NN	_	22	nmod	_	_
26	,	,	,	,	_	7	punct	_	_
27	and	and	CC	CC	_	7	cc	_	_
28	the	the	DT	DT	_	30	det	_	_
29	positive	positive	JJ	JJ	_	30	amod	_	_
30	correlation	correlation	NN	NN	_	7	conj	_	_
31	of	of	IN	IN	_	34	case	_	_
32	lining	lining	JJ	JJ	_	34	amod	_	_
33	layer	layer	NN	NN	_	34	compound	_	_
34	depth	depth	NN	NN	_	30	nmod	_	_
35	with	with	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	percentage	percentage	NN	NN	_	30	nmod	_	_
38	of	of	IN	IN	_	39	case	_	_
39	cells	cell	NNS	NNS	_	37	nmod	_	_
40	in	in	IN	IN	_	42	amod	_	_
41	the	the	DT	DT	_	42	det	_	_
42	lining	lining	JJ	JJ	_	39	dep	_	_
43	positive	positive	JJ	JJ	_	42	amod	_	_
44	for	for	IN	IN	_	47	case	_	_
45	nuclear	nuclear	JJ	JJ	_	47	amod	_	_
46	C/EBP	c/ebp	NN	NN	_	47	compound	_	_
47	beta	beta	NN	NN	_	43	nmod	_	_
48	,	,	,	,	_	49	punct	_	_
49	suggest	suggest	VBP	VBP	_	0	root	_	_
50	a	a	DT	DT	_	52	det	_	_
51	potential	potential	JJ	JJ	_	52	amod	_	_
52	role	role	NN	NN	_	49	dobj	_	_
53	for	for	IN	IN	_	55	case	_	_
54	C/EBP	c/ebp	NN	NN	_	55	compound	_	_
55	beta	beta	NN	NN	_	52	nmod	_	_
56	in	in	IN	IN	_	58	case	_	_
57	chronic	chronic	JJ	JJ	_	58	amod	_	_
58	inflammation	inflammation	NN	NN	_	52	nmod	_	_
59	.	.	.	.	_	49	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	regulation	regulation	NN	NN	_	23	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	production	production	NN	NN	_	2	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	activity	activity	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	C/EBP	c/ebp	NN	NN	_	10	compound	_	_
10	beta	beta	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	2	punct	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	inhibit	inhibit	VB	VB	_	2	acl	_	_
14	inflammatory	inflammatory	JJ	JJ	_	16	amod	_	_
15	mediator	mediator	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	synovial	synovial	JJ	JJ	_	19	amod	_	_
19	macrophages	macrophage	NNS	NNS	_	13	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	fibroblasts	fibroblast	NNS	NNS	_	19	conj	_	_
22	,	,	,	,	_	23	punct	_	_
23	offers	offer	VBZ	VBZ	_	0	root	_	_
24	a	a	DT	DT	_	26	det	_	_
25	novel	novel	JJ	JJ	_	26	amod	_	_
26	approach	approach	NN	NN	_	23	dobj	_	_
27	to	to	TO	TO	_	29	case	_	_
28	therapeutic	therapeutic	JJ	JJ	_	29	amod	_	_
29	intervention	intervention	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	23	punct	_	_

1	Novel	novel	JJ	JJ	_	2	amod	_	_
2	therapies	therapy	NNS	NNS	_	0	root	_	_
3	for	for	IN	IN	_	6	case	_	_
4	inflammatory	inflammatory	JJ	JJ	_	6	amod	_	_
5	bowel	bowel	NN	NN	_	6	compound	_	_
6	disease	disease	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Looking	look	VBG	VBG	_	16	advcl	_	_
2	back	back	RB	RB	_	1	advmod	_	_
3	at	at	IN	IN	_	4	case	_	_
4	successes	success	NNS	NNS	_	1	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	failures	failure	NNS	NNS	_	4	conj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	newer	newer	JJR	JJR	_	9	amod	_	_
9	approaches	approach	NNS	NNS	_	4	nmod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	treating	treat	VBG	VBG	_	9	acl	_	_
12	IBD	ibd	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	16	punct	_	_
14	it	it	PRP	PRP	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	tempting	tempting	JJ	JJ	_	0	root	_	_
17	--	--	:	:	_	20	punct	_	_
18	although	although	IN	IN	_	20	mark	_	_
19	still	still	RB	RB	_	20	advmod	_	_
20	difficult	difficult	JJ	JJ	_	16	dep	_	_
21	--	--	:	:	_	20	punct	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	draw	draw	VB	VB	_	16	xcomp	_	_
24	conclusions	conclusion	NNS	NNS	_	23	dobj	_	_
25	about	about	IN	IN	_	26	case	_	_
26	pathogenesis	pathogenesis	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	a	a	DT	DT	_	3	det	_	_
3	therapy	therapy	NN	NN	_	4	nsubj	_	_
4	proves	prove	VBZ	VBZ	_	0	root	_	_
5	effective	effective	JJ	JJ	_	4	xcomp	_	_
6	,	,	,	,	_	4	punct	_	_
7	do	do	VBP	VBP	_	10	aux	_	_
8	clinicians	clinician	NNS	NNS	_	10	nsubj	_	_
9	truly	truly	RB	RB	_	10	advmod	_	_
10	know	know	VB	VB	_	4	dep	_	_
11	how	how	WRB	WRB	_	13	advmod	_	_
12	it	it	PRP	PRP	_	13	nsubj	_	_
13	works	work	VBZ	VBZ	_	10	ccomp	_	_
14	?	?	.	.	_	4	punct	_	_

1	Even	even	RB	RB	_	14	advcl	_	_
2	with	with	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	therapy	therapy	NN	NN	_	1	nmod	_	_
5	as	as	IN	IN	_	6	dep	_	_
6	specific	specific	JJ	JJ	_	4	amod	_	_
7	as	as	IN	IN	_	9	case	_	_
8	anti-TNF	anti-tnf	JJ	JJ	_	9	amod	_	_
9	antibody	antibody	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	14	punct	_	_
11	it	it	PRP	PRP	_	14	nsubj	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	clear	clear	JJ	JJ	_	0	root	_	_
15	if	if	IN	IN	_	19	mark	_	_
16	the	the	DT	DT	_	17	det	_	_
17	benefit	benefit	NN	NN	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	attributable	attributable	JJ	JJ	_	14	advcl	_	_
20	to	to	TO	TO	_	22	case	_	_
21	simple	simple	JJ	JJ	_	22	amod	_	_
22	binding	binding	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	clearance	clearance	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	22	cc	_	_
28	to	to	TO	TO	_	29	case	_	_
29	binding	binding	NN	NN	_	22	conj	_	_
30	on	on	IN	IN	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	surface	surface	NN	NN	_	29	nmod	_	_
34	and	and	CC	CC	_	29	cc	_	_
35	subsequent	subsequent	JJ	JJ	_	36	amod	_	_
36	deletion	deletion	NN	NN	_	29	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	activated	activate	VBN	VBN	_	40	amod	_	_
40	macrophage	macrophage	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	14	punct	_	_

1	When	when	WRB	WRB	_	4	advmod	_	_
2	a	a	DT	DT	_	3	det	_	_
3	drug	drug	NN	NN	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	23	advcl	_	_
5	to	to	TO	TO	_	8	mark	_	_
6	be	be	VB	VB	_	8	cop	_	_
7	less	less	RBR	RBR	_	8	advmod	_	_
8	effective	effective	JJ	JJ	_	4	xcomp	_	_
9	than	than	IN	IN	_	12	mark	_	_
10	preclinical	preclinical	JJ	JJ	_	11	amod	_	_
11	models	model	NNS	NNS	_	12	nsubj	_	_
12	suggest	suggest	VBP	VBP	_	8	ccomp	_	_
13	,	,	,	,	_	23	punct	_	_
14	can	can	MD	MD	_	23	aux	_	_
15	failures	failure	NNS	NNS	_	23	nsubjpass	_	_
16	in	in	IN	IN	_	17	case	_	_
17	effectiveness	effectiveness	NN	NN	_	15	nmod	_	_
18	from	from	IN	IN	_	19	case	_	_
19	delivery	delivery	NN	NN	_	17	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	dosing	dosing	NN	NN	_	19	conj	_	_
22	be	be	VB	VB	_	23	auxpass	_	_
23	differentiated	differentiate	VBN	VBN	_	0	root	_	_
24	?	?	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	disappointing	disappointing	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	22	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	clinical	clinical	JJ	JJ	_	6	amod	_	_
6	trials	trial	NNS	NNS	_	3	nmod	_	_
7	with	with	IN	IN	_	8	case	_	_
8	IL-10	il-10	NN	NN	_	6	nmod	_	_
9	--	--	:	:	_	15	punct	_	_
10	so	so	RB	RB	_	15	dep	_	_
11	at	at	IN	IN	_	12	case	_	_
12	odds	odds	NNS	NNS	_	15	dep	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	prediction	prediction	NN	NN	_	3	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	benefit	benefit	NN	NN	_	15	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	animal	animal	NN	NN	_	20	compound	_	_
20	models	model	NNS	NNS	_	17	nmod	_	_
21	--	--	:	:	_	15	punct	_	_
22	bring	bring	VBP	VBP	_	0	root	_	_
23	into	into	IN	IN	_	24	case	_	_
24	question	question	NN	NN	_	22	nmod	_	_
25	the	the	DT	DT	_	26	det	_	_
26	validity	validity	NN	NN	_	22	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	those	those	DT	DT	_	29	det	_	_
29	models	model	NNS	NNS	_	26	nmod	_	_
30	as	as	RB	RB	_	26	cc	_	_
31	well	well	RB	RB	_	30	mwe	_	_
32	as	as	IN	IN	_	30	mwe	_	_
33	the	the	DT	DT	_	34	det	_	_
34	soundness	soundness	NN	NN	_	26	conj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	design	design	NN	NN	_	34	nmod	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	clinical	clinical	JJ	JJ	_	40	amod	_	_
40	trials	trial	NNS	NNS	_	36	nmod	_	_
41	on	on	IN	IN	_	42	case	_	_
42	which	which	WDT	WDT	_	47	nmod	_	_
43	efficacy	efficacy	NN	NN	_	47	nsubjpass	_	_
44	of	of	IN	IN	_	45	case	_	_
45	IL-10	il-10	NN	NN	_	43	nmod	_	_
46	is	be	VBZ	VBZ	_	47	auxpass	_	_
47	judged	judge	VBN	VBN	_	40	acl:relcl	_	_
48	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	variability	variability	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	response	response	NN	NN	_	2	nmod	_	_
5	even	even	RB	RB	_	4	acl	_	_
6	to	to	TO	TO	_	11	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	most	most	RBS	RBS	_	9	advmod	_	_
9	narrowly	narrowly	RB	RB	_	10	advmod	_	_
10	targeted	target	VBN	VBN	_	11	amod	_	_
11	agents	agent	NNS	NNS	_	5	nmod	_	_
12	suggests	suggest	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	19	mark	_	_
14	these	these	DT	DT	_	15	det	_	_
15	diseases	disease	NNS	NNS	_	19	nsubj	_	_
16	are	be	VBP	VBP	_	19	cop	_	_
17	far	far	RB	RB	_	18	advmod	_	_
18	more	more	RBR	RBR	_	19	advmod	_	_
19	heterogeneous	heterogeneous	JJ	JJ	_	12	ccomp	_	_
20	in	in	IN	IN	_	21	case	_	_
21	humans	human	NNS	NNS	_	19	nmod	_	_
22	than	than	IN	IN	_	26	case	_	_
23	in	in	IN	IN	_	26	case	_	_
24	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
25	murine	murine	JJ	JJ	_	26	amod	_	_
26	counterparts	counterpart	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	Clinicians	clinician	NNS	NNS	_	5	nsubj	_	_
2	are	be	VBP	VBP	_	5	aux	_	_
3	only	only	RB	RB	_	5	advmod	_	_
4	just	just	RB	RB	_	5	advmod	_	_
5	beginning	begin	VBG	VBG	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	recognize	recognize	VB	VB	_	5	xcomp	_	_
8	subclinical	subclinical	JJ	JJ	_	9	amod	_	_
9	markers	marker	NNS	NNS	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	response	response	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	it	it	PRP	PRP	_	18	nsubj	_	_
15	may	may	MD	MD	_	18	aux	_	_
16	soon	soon	RB	RB	_	18	advmod	_	_
17	be	be	VB	VB	_	18	cop	_	_
18	possible	possible	JJ	JJ	_	5	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	predict	predict	VB	VB	_	18	xcomp	_	_
21	response	response	NN	NN	_	20	dobj	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	basis	basis	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	genetic	genetic	JJ	JJ	_	27	amod	_	_
27	composition	composition	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	moment	moment	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	however	however	RB	RB	_	12	advmod	_	_
6	,	,	,	,	_	12	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	field	field	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	pharmacogenetics	pharmacogenetic	NNS	NNS	_	8	nmod	_	_
11	is	be	VBZ	VBZ	_	12	cop	_	_
12	embryonic	embryonic	JJ	JJ	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Challenges	challenge	NNS	NNS	_	7	nsubj	_	_
2	in	in	IN	IN	_	3	mark	_	_
3	developing	develop	VBG	VBG	_	1	acl	_	_
4	new	new	JJ	JJ	_	6	amod	_	_
5	therapeutic	therapeutic	JJ	JJ	_	6	amod	_	_
6	strategies	strategy	NNS	NNS	_	3	dobj	_	_
7	include	include	VBP	VBP	_	0	root	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	only	only	RB	RB	_	10	advmod	_	_
10	identifying	identify	VBG	VBG	_	7	xcomp	_	_
11	novel	novel	JJ	JJ	_	12	amod	_	_
12	agents	agent	NNS	NNS	_	10	dobj	_	_
13	,	,	,	,	_	10	punct	_	_
14	but	but	CC	CC	_	10	cc	_	_
15	also	also	RB	RB	_	10	advmod	_	_
16	improving	improve	VBG	VBG	_	10	dep	_	_
17	the	the	DT	DT	_	18	det	_	_
18	definitions	definition	NNS	NNS	_	16	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	clinical	clinical	JJ	JJ	_	21	amod	_	_
21	endpoints	endpoint	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	defining	define	VBG	VBG	_	16	conj	_	_
24	efficacy	efficacy	NN	NN	_	23	dobj	_	_
25	at	at	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	biologic	biologic	JJ	JJ	_	28	amod	_	_
28	level	level	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	Only	only	RB	RB	_	10	nmod	_	_
2	through	through	IN	IN	_	4	case	_	_
3	considered	consider	VBN	VBN	_	4	amod	_	_
4	evaluation	evaluation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	clinical	clinical	JJ	JJ	_	7	amod	_	_
7	evidence	evidence	NN	NN	_	4	nmod	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	clinicians	clinician	NNS	NNS	_	10	nsubj	_	_
10	determine	determine	VB	VB	_	0	root	_	_
11	which	which	WDT	WDT	_	12	det	_	_
12	therapies	therapy	NNS	NNS	_	14	nsubj	_	_
13	should	should	MD	MD	_	14	aux	_	_
14	remain	remain	VB	VB	_	10	dep	_	_
15	novelties	novelty	NNS	NNS	_	14	xcomp	_	_
16	and	and	CC	CC	_	14	cc	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	should	should	MD	MD	_	19	aux	_	_
19	become	become	VB	VB	_	14	conj	_	_
20	an	a	DT	DT	_	22	det	_	_
21	accepted	accept	VBN	VBN	_	22	amod	_	_
22	part	part	NN	NN	_	19	xcomp	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	armamentarium	armamentarium	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	10	punct	_	_

1	p70(s6k)	p70(s6k)	NN	NN	_	2	nsubj	_	_
2	integrates	integrate	VBZ	VBZ	_	0	root	_	_
3	phosphatidylinositol	phosphatidylinositol	NN	NN	_	4	compound	_	_
4	3-kinase	3-kinase	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	rapamycin-regulated	rapamycin-regulated	JJ	JJ	_	7	amod	_	_
7	signals	signal	NNS	NNS	_	4	conj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	E2F	e2f	NN	NN	_	10	compound	_	_
10	regulation	regulation	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	T	t	NN	NN	_	3	compound	_	_
3	lymphocytes	lymphocyte	NNS	NNS	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	the	the	DT	DT	_	7	det	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
7	cytokine	cytokine	NN	NN	_	12	nsubj	_	_
8	interleukin-2	interleukin-2	NN	NN	_	7	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-2	il-2	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	uses	use	VBZ	VBZ	_	0	root	_	_
13	phosphatidylinositol	phosphatidylinositol	NN	NN	_	14	compound	_	_
14	3-kinase	3-kinase	NN	NN	_	21	compound	_	_
15	(	(	-LRB-	-LRB-	_	17	punct	_	_
16	PI	pi	NN	NN	_	17	compound	_	_
17	3-kinase	3-kinase	NN	NN	_	14	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	-induced	-induced	JJ	JJ	_	21	amod	_	_
20	signaling	signaling	NN	NN	_	21	compound	_	_
21	pathways	pathway	NNS	NNS	_	12	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	regulate	regulate	VB	VB	_	12	advcl	_	_
24	E2F	e2f	NN	NN	_	26	compound	_	_
25	transcriptional	transcriptional	JJ	JJ	_	26	amod	_	_
26	activity	activity	NN	NN	_	23	dobj	_	_
27	,	,	,	,	_	26	punct	_	_
28	a	a	DT	DT	_	32	det	_	_
29	critical	critical	JJ	JJ	_	32	amod	_	_
30	cell	cell	NN	NN	_	32	compound	_	_
31	cycle	cycle	NN	NN	_	32	compound	_	_
32	checkpoint	checkpoint	NN	NN	_	26	appos	_	_
33	.	.	.	.	_	12	punct	_	_

1	PI	pi	NN	NN	_	2	compound	_	_
2	3-kinase	3-kinase	NN	NN	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	regulates	regulate	VBZ	VBZ	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p70(s6k)	p70(s6k)	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	the	the	DT	DT	_	15	det	_	_
11	40S	40s	JJ	JJ	_	15	amod	_	_
12	ribosomal	ribosomal	JJ	JJ	_	15	amod	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	S6	s6	NN	NN	_	15	compound	_	_
15	kinase	kinase	NN	NN	_	8	appos	_	_
16	,	,	,	,	_	6	punct	_	_
17	a	a	DT	DT	_	18	det	_	_
18	response	response	NN	NN	_	6	appos	_	_
19	that	that	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	abrogated	abrogate	VBN	VBN	_	18	acl:relcl	_	_
22	by	by	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	macrolide	macrolide	NN	NN	_	21	nmod	_	_
25	rapamycin	rapamycin	NN	NN	_	24	dep	_	_
26	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	immunosuppressive	immunosuppressive	JJ	JJ	_	3	amod	_	_
3	drug	drug	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	prevent	prevent	VB	VB	_	5	xcomp	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	proliferation	proliferation	NN	NN	_	7	dobj	_	_
10	,	,	,	,	_	5	punct	_	_
11	but	but	CC	CC	_	5	cc	_	_
12	the	the	DT	DT	_	14	det	_	_
13	precise	precise	JJ	JJ	_	14	amod	_	_
14	point	point	NN	NN	_	22	nsubj	_	_
15	at	at	IN	IN	_	16	dep	_	_
16	which	which	WDT	WDT	_	18	advmod	_	_
17	rapamycin	rapamycin	NN	NN	_	18	nsubj	_	_
18	regulates	regulate	VBZ	VBZ	_	14	dep	_	_
19	T-cell	t-cell	NN	NN	_	21	compound	_	_
20	cycle	cycle	NN	NN	_	21	compound	_	_
21	progression	progression	NN	NN	_	18	dobj	_	_
22	has	have	VBZ	VBZ	_	5	conj	_	_
23	yet	yet	RB	RB	_	26	advmod	_	_
24	to	to	TO	TO	_	26	mark	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	elucidated	elucidate	VBN	VBN	_	22	xcomp	_	_
27	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	26	advmod	_	_
2	,	,	,	,	_	26	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	26	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	rapamycin	rapamycin	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	4	acl	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	role	role	NN	NN	_	4	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	p70(s6k)	p70(s6k)	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	11	acl	_	_
15	,	,	,	,	_	4	punct	_	_
16	IL-2	il-2	NN	NN	_	20	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	PI	pi	NN	NN	_	19	compound	_	_
19	3-kinase	3-kinase	NN	NN	_	16	conj	_	_
20	activation	activation	NN	NN	_	4	appos	_	_
21	of	of	IN	IN	_	22	case	_	_
22	E2Fs	e2f	NNS	NNS	_	20	nmod	_	_
23	have	have	VBP	VBP	_	26	aux	_	_
24	not	not	RB	RB	_	26	neg	_	_
25	been	be	VBN	VBN	_	26	auxpass	_	_
26	characterized	characterize	VBN	VBN	_	0	root	_	_
27	.	.	.	.	_	26	punct	_	_

1	Our	we	PRP$	PRP$	_	3	nmod:poss	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	18	mark	_	_
6	IL-2-	il-2-	NN	NN	_	18	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	PI	pi	NN	NN	_	10	compound	_	_
9	3-kinase-induced	3-kinase-induced	JJ	JJ	_	10	amod	_	_
10	pathways	pathway	NNS	NNS	_	6	conj	_	_
11	for	for	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	regulation	regulation	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	E2F	e2f	NN	NN	_	17	compound	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	include	include	VBP	VBP	_	4	ccomp	_	_
19	both	both	CC	CC	_	20	cc:preconj	_	_
20	rapamycin-resistant	rapamycin-resistant	JJ	JJ	_	23	amod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	rapamycin-sensitive	rapamycin-sensitive	JJ	JJ	_	20	conj	_	_
23	components	component	NNS	NNS	_	18	dobj	_	_
24	.	.	.	.	_	4	punct	_	_

1	Expression	expression	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	rapamycin-resistant	rapamycin-resistant	JJ	JJ	_	5	amod	_	_
5	mutant	mutant	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	p70(s6k)	p70(s6k)	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	could	could	MD	MD	_	12	aux	_	_
12	restore	restore	VB	VB	_	0	root	_	_
13	rapamycin-suppressed	rapamycin-suppressed	JJ	JJ	_	15	amod	_	_
14	E2F	e2f	NN	NN	_	15	compound	_	_
15	responses	response	NNS	NNS	_	12	dobj	_	_
16	.	.	.	.	_	12	punct	_	_

1	Thus	thus	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	rapamycin-controlled	rapamycin-controlled	JJ	JJ	_	5	amod	_	_
5	processes	process	NNS	NNS	_	10	nsubj	_	_
6	involved	involve	VBN	VBN	_	5	acl	_	_
7	in	in	IN	IN	_	9	case	_	_
8	E2F	e2f	NN	NN	_	9	compound	_	_
9	regulation	regulation	NN	NN	_	6	nmod	_	_
10	appear	appear	VBP	VBP	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	10	xcomp	_	_
14	by	by	IN	IN	_	15	case	_	_
15	p70(s6k)	p70(s6k)	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	rapamycin-resistant	rapamycin-resistant	JJ	JJ	_	5	amod	_	_
5	p70(s6k)	p70(s6k)	NN	NN	_	8	nsubj	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	rescue	rescue	VB	VB	_	0	root	_	_
9	rapamycin	rapamycin	NN	NN	_	10	compound	_	_
10	inhibition	inhibition	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	T-cell	t-cell	NN	NN	_	14	compound	_	_
13	cycle	cycle	NN	NN	_	14	compound	_	_
14	entry	entry	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	consistent	consistent	JJ	JJ	_	14	amod	_	_
17	with	with	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	involvement	involvement	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	additional	additional	JJ	JJ	_	24	amod	_	_
22	,	,	,	,	_	21	punct	_	_
23	rapamycin-sensitive	rapamycin-sensitive	JJ	JJ	_	21	dep	_	_
24	pathways	pathway	NNS	NNS	_	19	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	control	control	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	T-cell	t-cell	NN	NN	_	31	compound	_	_
30	cycle	cycle	NN	NN	_	31	compound	_	_
31	progression	progression	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	results	result	NNS	NNS	_	5	nsubj	_	_
4	thus	thus	RB	RB	_	5	advmod	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	p70(s6k)	p70(s6k)	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	able	able	JJ	JJ	_	5	ccomp	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	regulate	regulate	VB	VB	_	9	xcomp	_	_
12	E2F	e2f	NN	NN	_	14	compound	_	_
13	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
14	activity	activity	NN	NN	_	11	dobj	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	provide	provide	VB	VB	_	5	conj	_	_
17	direct	direct	JJ	JJ	_	18	amod	_	_
18	evidence	evidence	NN	NN	_	16	dobj	_	_
19	for	for	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	first	first	JJ	JJ	_	22	amod	_	_
22	time	time	NN	NN	_	16	nmod	_	_
23	for	for	IN	IN	_	25	case	_	_
24	a	a	DT	DT	_	25	det	_	_
25	link	link	NN	NN	_	16	nmod	_	_
26	between	between	IN	IN	_	28	case	_	_
27	IL-2	il-2	NN	NN	_	28	compound	_	_
28	receptors	receptor	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	PI	pi	NN	NN	_	31	compound	_	_
31	3-kinase	3-kinase	NN	NN	_	28	conj	_	_
32	,	,	,	,	_	28	punct	_	_
33	and	and	CC	CC	_	28	cc	_	_
34	p70(s6k)	p70(s6k)	NN	NN	_	28	conj	_	_
35	that	that	WDT	WDT	_	36	nsubj	_	_
36	regulates	regulate	VBZ	VBZ	_	34	acl:relcl	_	_
37	a	a	DT	DT	_	40	det	_	_
38	crucial	crucial	JJ	JJ	_	40	amod	_	_
39	G1	g1	NN	NN	_	40	compound	_	_
40	checkpoint	checkpoint	NN	NN	_	36	dobj	_	_
41	in	in	IN	IN	_	43	case	_	_
42	T	t	NN	NN	_	43	compound	_	_
43	lymphocytes	lymphocyte	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	5	punct	_	_

1	SOCS-3	socs-3	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	tyrosine	tyrosine	NN	NN	_	4	nmod:npmod	_	_
4	phosphorylated	phosphorylated	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	response	response	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	interleukin-2	interleukin-2	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	suppresses	suppress	VBZ	VBZ	_	4	conj	_	_
11	STAT5	stat5	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	lymphocyte	lymphocyte	NN	NN	_	15	compound	_	_
15	proliferation	proliferation	NN	NN	_	12	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Members	member	NNS	NNS	_	10	nsubjpass	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	recently	recently	RB	RB	_	5	advmod	_	_
5	discovered	discover	VBN	VBN	_	7	amod	_	_
6	SOCS/CIS/SSI	socs/cis/ssi	NN	NN	_	7	compound	_	_
7	family	family	NN	NN	_	1	nmod	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	proposed	propose	VBN	VBN	_	0	root	_	_
11	as	as	IN	IN	_	12	case	_	_
12	regulators	regulator	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	signaling	signaling	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	10	punct	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	while	while	IN	IN	_	24	mark	_	_
19	targets	target	NNS	NNS	_	24	nsubjpass	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	mechanisms	mechanism	NNS	NNS	_	19	conj	_	_
22	have	have	VBP	VBP	_	24	aux	_	_
23	been	be	VBN	VBN	_	24	auxpass	_	_
24	suggested	suggest	VBN	VBN	_	36	advcl	_	_
25	for	for	IN	IN	_	28	case	_	_
26	some	some	DT	DT	_	28	det	_	_
27	family	family	NN	NN	_	28	compound	_	_
28	members	member	NNS	NNS	_	24	nmod	_	_
29	,	,	,	,	_	36	punct	_	_
30	the	the	DT	DT	_	32	det	_	_
31	precise	precise	JJ	JJ	_	32	amod	_	_
32	role	role	NN	NN	_	36	nsubj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	proteins	protein	NNS	NNS	_	32	nmod	_	_
36	remains	remain	VBZ	VBZ	_	10	conj	_	_
37	to	to	TO	TO	_	39	mark	_	_
38	be	be	VB	VB	_	39	auxpass	_	_
39	defined	define	VBN	VBN	_	36	xcomp	_	_
40	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	case	_	_
2	date	date	VB	VB	_	9	nmod	_	_
3	no	no	DT	DT	_	5	neg	_	_
4	SOCS	socs	NN	NN	_	5	compound	_	_
5	proteins	protein	NNS	NNS	_	9	nsubjpass	_	_
6	have	have	VBP	VBP	_	9	aux	_	_
7	been	be	VBN	VBN	_	9	auxpass	_	_
8	specifically	specifically	RB	RB	_	9	advmod	_	_
9	implicated	implicate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	interleukin-2	interleukin-2	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IL-2	il-2	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	signaling	signaling	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	SOCS-3	socs-3	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	response	response	NN	NN	_	5	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	IL-2	il-2	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	13	case	_	_
11	both	both	CC	CC	_	13	cc:preconj	_	_
12	T-cell	t-cell	NN	NN	_	13	compound	_	_
13	lines	line	NNS	NNS	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	human	human	JJ	JJ	_	18	amod	_	_
16	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
17	blood	blood	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	13	conj	_	_
19	.	.	.	.	_	3	punct	_	_

1	SOCS-3	socs-3	NN	NN	_	2	compound	_	_
2	protein	protein	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	detectable	detectable	JJ	JJ	_	0	root	_	_
5	as	as	RB	RB	_	6	advmod	_	_
6	early	early	RB	RB	_	4	advmod	_	_
7	as	as	IN	IN	_	9	case	_	_
8	30	30	CD	CD	_	9	nummod	_	_
9	min	min	NN	NN	_	6	nmod	_	_
10	following	follow	VBG	VBG	_	12	case	_	_
11	IL-2	il-2	NN	NN	_	12	compound	_	_
12	stimulation	stimulation	NN	NN	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	while	while	IN	IN	_	17	mark	_	_
15	CIS	cis	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	seen	see	VBN	VBN	_	4	dep	_	_
18	only	only	RB	RB	_	17	advmod	_	_
19	at	at	IN	IN	_	21	case	_	_
20	low	low	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	17	nmod	_	_
22	after	after	IN	IN	_	24	case	_	_
23	2	2	CD	CD	_	24	nummod	_	_
24	h	h	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	CIS	cis	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	SOCS-3	socs-3	NN	NN	_	8	nsubj	_	_
5	was	be	VBD	VBD	_	8	cop	_	_
6	rapidly	rapidly	RB	RB	_	8	advmod	_	_
7	tyrosine	tyrosine	NN	NN	_	8	nmod:npmod	_	_
8	phosphorylated	phosphorylated	JJ	JJ	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	response	response	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	IL-2	il-2	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	8	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	compound	_	_
2	phosphorylation	phosphorylation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SOCS-3	socs-3	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	observed	observe	VBN	VBN	_	0	root	_	_
7	upon	upon	IN	IN	_	8	case	_	_
8	coexpression	coexpression	NN	NN	_	6	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	Jak1	jak1	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Jak2	jak2	NN	NN	_	10	conj	_	_
13	but	but	CC	CC	_	10	cc	_	_
14	only	only	RB	RB	_	15	advmod	_	_
15	weakly	weakly	RB	RB	_	10	conj	_	_
16	with	with	IN	IN	_	17	case	_	_
17	Jak3	jak3	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	these	these	DT	DT	_	3	det	_	_
3	experiments	experiment	NNS	NNS	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	SOCS-3	socs-3	NN	NN	_	6	nsubj	_	_
6	associated	associate	VBD	VBD	_	0	root	_	_
7	with	with	IN	IN	_	8	case	_	_
8	Jak1	jak1	NN	NN	_	6	nmod	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	inhibited	inhibit	VBD	VBD	_	6	conj	_	_
11	Jak1	jak1	NN	NN	_	12	compound	_	_
12	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	6	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	this	this	DT	DT	_	16	det	_	_
16	inhibition	inhibition	NN	NN	_	19	nsubjpass	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	markedly	markedly	RB	RB	_	19	advmod	_	_
19	enhanced	enhance	VBN	VBN	_	6	conj	_	_
20	by	by	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	presence	presence	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	IL-2	il-2	NN	NN	_	27	compound	_	_
25	receptor	receptor	NN	NN	_	27	compound	_	_
26	beta	beta	NN	NN	_	27	compound	_	_
27	chain	chain	NN	NN	_	22	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	IL-2Rbeta	il-2rbeta	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	6	punct	_	_

1	Moreover	moreover	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	following	follow	VBG	VBG	_	5	case	_	_
4	IL-2	il-2	NN	NN	_	5	compound	_	_
5	stimulation	stimulation	NN	NN	_	12	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	12	punct	_	_
10	SOCS-3	socs-3	NN	NN	_	12	nsubj	_	_
11	was	be	VBD	VBD	_	12	cop	_	_
12	able	able	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	interact	interact	VB	VB	_	12	xcomp	_	_
15	with	with	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	dep	_	_
17	IL-2	il-2	NN	NN	_	19	compound	_	_
18	receptor	receptor	NN	NN	_	19	compound	_	_
19	complex	complex	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	in	in	IN	IN	_	23	case	_	_
23	particular	particular	JJ	JJ	_	19	conj	_	_
24	tyrosine	tyrosine	NN	NN	_	26	compound	_	_
25	phosphorylated	phosphorylated	JJ	JJ	_	26	amod	_	_
26	Jak1	jak1	NN	NN	_	19	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	IL-2Rbeta	il-2rbeta	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	12	punct	_	_

1	Additionally	additionally	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	18	nmod	_	_
5	expressing	express	VBG	VBG	_	4	acl	_	_
6	SOCS-3	socs-3	NN	NN	_	5	dobj	_	_
7	but	but	CC	CC	_	6	cc	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	CIS	cis	NN	NN	_	6	conj	_	_
10	,	,	,	,	_	18	punct	_	_
11	IL-2-induced	il-2-induced	JJ	JJ	_	13	amod	_	_
12	tyrosine	tyrosine	NN	NN	_	13	compound	_	_
13	phosphorylation	phosphorylation	NN	NN	_	18	nsubjpass	_	_
14	of	of	IN	IN	_	15	case	_	_
15	STAT5b	stat5b	NN	NN	_	13	nmod	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	markedly	markedly	RB	RB	_	18	advmod	_	_
18	reduced	reduce	VBN	VBN	_	0	root	_	_
19	,	,	,	,	_	18	punct	_	_
20	while	while	IN	IN	_	22	mark	_	_
21	there	there	EX	EX	_	22	expl	_	_
22	was	be	VBD	VBD	_	18	dep	_	_
23	only	only	RB	RB	_	22	advmod	_	_
24	a	a	DT	DT	_	26	det	_	_
25	weak	weak	JJ	JJ	_	26	amod	_	_
26	effect	effect	NN	NN	_	22	nsubj	_	_
27	on	on	IN	IN	_	29	case	_	_
28	IL-3-mediated	il-3-mediated	JJ	JJ	_	29	amod	_	_
29	STAT5b	stat5b	NN	NN	_	26	nmod	_	_
30	tyrosine	tyrosine	NN	NN	_	31	compound	_	_
31	phosphorylation	phosphorylation	NN	NN	_	29	dep	_	_
32	.	.	.	.	_	22	punct	_	_

1	Finally	finally	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	proliferation	proliferation	NN	NN	_	12	nsubj	_	_
4	induced	induce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	IL-2-	il-2-	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-3	il-3	NN	NN	_	7	conj	_	_
10	was	be	VBD	VBD	_	12	aux	_	_
11	significantly	significantly	RB	RB	_	12	advmod	_	_
12	inhibited	inhibited	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	presence	presence	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	SOCS-3	socs-3	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	when	when	WRB	WRB	_	9	advmod	_	_
6	SOCS-3	socs-3	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	rapidly	rapidly	RB	RB	_	9	advmod	_	_
9	induced	induce	VBN	VBN	_	17	advcl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	IL-2	il-2	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	17	punct	_	_
16	it	it	PRP	PRP	_	17	nsubj	_	_
17	acts	act	VBZ	VBZ	_	3	ccomp	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	inhibit	inhibit	VB	VB	_	17	xcomp	_	_
20	IL-2	il-2	NN	NN	_	21	compound	_	_
21	responses	response	NNS	NNS	_	19	dobj	_	_
22	in	in	IN	IN	_	27	case	_	_
23	a	a	DT	DT	_	27	det	_	_
24	classical	classical	JJ	JJ	_	27	amod	_	_
25	negative	negative	JJ	JJ	_	27	amod	_	_
26	feedback	feedback	NN	NN	_	27	compound	_	_
27	loop	loop	NN	NN	_	19	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	9	case	_	_
4	gamma/delta	gamma/delta	NN	NN	_	9	compound	_	_
5	T	t	NN	NN	_	9	compound	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	receptor	receptor	NN	NN	_	9	compound	_	_
8	positive	positive	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	2	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	pregnancy	pregnancy	NN	NN	_	2	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	PROBLEM	problem	NN	NN	_	19	nsubjpass	_	_
2	:	:	:	:	_	19	punct	_	_
3	Due	due	JJ	JJ	_	6	case	_	_
4	to	to	TO	TO	_	3	mwe	_	_
5	the	the	DT	DT	_	6	det	_	_
6	lack	lack	NN	NN	_	19	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	classical	classical	JJ	JJ	_	10	amod	_	_
9	HLA	hla	NN	NN	_	10	compound	_	_
10	antigens	antigen	NNS	NNS	_	6	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	trophoblast	trophoblast	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	19	punct	_	_
15	fetal	fetal	JJ	JJ	_	16	amod	_	_
16	antigens	antigen	NNS	NNS	_	19	nsubjpass	_	_
17	are	be	VBP	VBP	_	19	auxpass	_	_
18	possibly	possibly	RB	RB	_	19	advmod	_	_
19	presented	present	VBN	VBN	_	0	root	_	_
20	in	in	IN	IN	_	30	case	_	_
21	a	a	DT	DT	_	30	det	_	_
22	non	non	JJ	JJ	_	30	amod	_	_
23	major	major	JJ	JJ	_	25	amod	_	_
24	histocompatibility	histocompatibility	NN	NN	_	25	compound	_	_
25	complex	complex	NN	NN	_	30	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	MHC	mhc	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	restricted	restricted	JJ	JJ	_	30	amod	_	_
30	way	way	NN	NN	_	19	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	Decidual	decidual	JJ	JJ	_	4	amod	_	_
2	gammadelta	gammadelta	NN	NN	_	4	compound	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	15	nsubj	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	8	nsubj	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	increase	increase	VBP	VBP	_	4	acl:relcl	_	_
9	in	in	IN	IN	_	10	case	_	_
10	number	number	NN	NN	_	8	nmod	_	_
11	during	during	IN	IN	_	12	case	_	_
12	pregnancy	pregnancy	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	15	punct	_	_
14	might	might	MD	MD	_	15	aux	_	_
15	play	play	VB	VB	_	0	root	_	_
16	a	a	DT	DT	_	17	det	_	_
17	role	role	NN	NN	_	15	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	recognition	recognition	NN	NN	_	17	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	fetal	fetal	JJ	JJ	_	22	amod	_	_
22	antigens	antigen	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	19	cc	_	_
24	also	also	RB	RB	_	26	advmod	_	_
25	in	in	IN	IN	_	26	mark	_	_
26	determining	determine	VBG	VBG	_	19	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	quality	quality	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	response	response	NN	NN	_	28	nmod	_	_
32	to	to	TO	TO	_	34	case	_	_
33	these	these	DT	DT	_	34	det	_	_
34	antigens	antigen	NNS	NNS	_	31	nmod	_	_
35	.	.	.	.	_	15	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	study	study	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	aimed	aim	VBN	VBN	_	0	root	_	_
5	at	at	IN	IN	_	6	mark	_	_
6	investigating	investigate	VBG	VBG	_	4	advcl	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	this	this	DT	DT	_	12	det	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	population	population	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	progesterone-dependent	progesterone-dependent	JJ	JJ	_	15	amod	_	_
15	immunomodulation	immunomodulation	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	METHOD	method	NN	NN	_	16	nsubjpass	_	_
2	OF	of	IN	IN	_	3	case	_	_
3	STUDY	study	NN	NN	_	1	nmod	_	_
4	:	:	:	:	_	16	punct	_	_
5	Peripheral	peripheral	JJ	JJ	_	6	amod	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubjpass	_	_
7	from	from	IN	IN	_	10	case	_	_
8	healthy	healthy	JJ	JJ	_	10	amod	_	_
9	pregnant	pregnant	JJ	JJ	_	10	amod	_	_
10	women	woman	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	from	from	IN	IN	_	14	case	_	_
13	habitual	habitual	JJ	JJ	_	14	amod	_	_
14	aborters	aborter	NNS	NNS	_	10	conj	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	tested	test	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	immunocytochemistry	immunocytochemistry	NN	NN	_	16	nmod	_	_
19	for	for	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	gamma/delta	gamma/delta	NN	NN	_	21	nmod	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	receptor	receptor	NN	NN	_	23	dep	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	TCR	tcr	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	and	and	CC	CC	_	23	cc	_	_
31	progesterone	progesterone	NN	NN	_	32	compound	_	_
32	receptor	receptor	NN	NN	_	23	conj	_	_
33	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	treatment	treatment	NN	NN	_	4	nmod	_	_
7	with	with	IN	IN	_	12	case	_	_
8	a	a	DT	DT	_	12	det	_	_
9	pan	pan	NN	NN	_	12	compound	_	_
10	anti	anti	JJ	JJ	_	12	amod	_	_
11	gamma/delta	gamma/delta	NN	NN	_	12	compound	_	_
12	antibody	antibody	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	2	punct	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubjpass	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	incubated	incubate	VBN	VBN	_	2	ccomp	_	_
17	for	for	IN	IN	_	19	case	_	_
18	3	3	CD	CD	_	19	nummod	_	_
19	hr	hr	NN	NN	_	16	nmod	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	antibody	antibody	NN	NN	_	16	nmod	_	_
23	,	,	,	,	_	2	punct	_	_
24	and	and	CC	CC	_	2	cc	_	_
25	then	then	RB	RB	_	56	advmod	_	_
26	interleukin	interleukin	NN	NN	_	56	nsubjpass	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	IL	il	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	-10	-10	CD	CD	_	26	nummod	_	_
31	,	,	,	,	_	26	punct	_	_
32	IL-12	il-12	NN	NN	_	26	conj	_	_
33	and	and	CC	CC	_	26	cc	_	_
34	progesterone-induced	progesterone-induced	JJ	JJ	_	36	amod	_	_
35	blocking	block	VBG	VBG	_	36	amod	_	_
36	factor	factor	NN	NN	_	40	compound	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	PIBF	pibf	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	expression	expression	NN	NN	_	26	conj	_	_
41	(	(	-LRB-	-LRB-	_	43	punct	_	_
42	by	by	IN	IN	_	43	case	_	_
43	immuno-cytochemistry	immuno-cytochemistry	NN	NN	_	26	nmod	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	as	as	RB	RB	_	26	cc	_	_
46	well	well	RB	RB	_	45	mwe	_	_
47	as	as	IN	IN	_	45	mwe	_	_
48	natural	natural	JJ	JJ	_	49	amod	_	_
49	killer	killer	NN	NN	_	54	compound	_	_
50	(	(	-LRB-	-LRB-	_	51	punct	_	_
51	NK	nk	NN	NN	_	49	appos	_	_
52	)	)	-RRB-	-RRB-	_	51	punct	_	_
53	cell	cell	NN	NN	_	54	compound	_	_
54	activity	activity	NN	NN	_	26	conj	_	_
55	were	be	VBD	VBD	_	56	auxpass	_	_
56	determined	determine	VBN	VBN	_	2	conj	_	_
57	.	.	.	.	_	2	punct	_	_

1	RESULTS	result	NNS	NNS	_	18	nsubj	_	_
2	:	:	:	:	_	18	punct	_	_
3	In	in	IN	IN	_	5	case	_	_
4	peripheral	peripheral	JJ	JJ	_	5	amod	_	_
5	blood	blood	NN	NN	_	18	nmod	_	_
6	of	of	IN	IN	_	9	case	_	_
7	healthy	healthy	JJ	JJ	_	9	amod	_	_
8	pregnant	pregnant	JJ	JJ	_	9	amod	_	_
9	women	woman	NNS	NNS	_	5	nmod	_	_
10	the	the	DT	DT	_	11	det	_	_
11	percentage	percentage	NN	NN	_	18	nsubj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	gamma/delta	gamma/delta	NN	NN	_	15	compound	_	_
14	TCR+	tcr+	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	was	be	VBD	VBD	_	18	cop	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	higher	higher	JJR	JJR	_	0	root	_	_
19	(	(	-LRB-	-LRB-	_	22	punct	_	_
20	P	p	NN	NN	_	22	nsubj	_	_
21	&lt;	&lt;	JJR	JJR	_	22	dep	_	_
22	0.001	0.001	CD	CD	_	18	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	than	than	IN	IN	_	26	mark	_	_
25	in	in	IN	IN	_	26	case	_	_
26	that	that	DT	DT	_	18	dep	_	_
27	of	of	IN	IN	_	29	case	_	_
28	recurrent	recurrent	JJ	JJ	_	29	amod	_	_
29	aborters	aborter	NNS	NNS	_	26	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	of	of	IN	IN	_	33	case	_	_
32	non-pregnant	non-pregnant	JJ	JJ	_	33	amod	_	_
33	individuals	individual	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	18	punct	_	_

1	Ninety-seven	ninety-seven	CD	CD	_	2	nummod	_	_
2	percent	percent	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	gamma/delta	gamma/delta	NN	NN	_	7	compound	_	_
5	TCR+	tcr+	JJ	JJ	_	7	amod	_	_
6	pregnancy	pregnancy	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
8	expressed	express	VBD	VBD	_	0	root	_	_
9	progesterone	progesterone	NN	NN	_	10	compound	_	_
10	receptor	receptor	NN	NN	_	8	dobj	_	_
11	.	.	.	.	_	8	punct	_	_

1	Binding	binding	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	specific	specific	JJ	JJ	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	gamma/delta	gamma/delta	NN	NN	_	9	compound	_	_
9	TCR	tcr	NN	NN	_	5	nmod	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	PIBF-	pibf-	NN	NN	_	16	compound	_	_
12	as	as	RB	RB	_	11	cc	_	_
13	well	well	RB	RB	_	12	mwe	_	_
14	as	as	IN	IN	_	12	mwe	_	_
15	IL-10	il-10	NN	NN	_	11	conj	_	_
16	production	production	NN	NN	_	10	dobj	_	_
17	,	,	,	,	_	10	punct	_	_
18	whereas	whereas	IN	IN	_	10	dep	_	_
19	it	it	PRP	PRP	_	20	nsubj	_	_
20	increased	increase	VBD	VBD	_	10	parataxis	_	_
21	NK	nk	NN	NN	_	22	compound	_	_
22	activity	activity	NN	NN	_	20	dobj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-12	il-12	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	conj	_	_
26	.	.	.	.	_	10	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	5	nsubj	_	_
2	:	:	:	:	_	5	punct	_	_
3	These	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	gamma/delta	gamma/delta	NN	NN	_	11	compound	_	_
10	TCR-bearing	tcr-bearing	JJ	JJ	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	progesterone-dependent	progesterone-dependent	JJ	JJ	_	14	amod	_	_
14	immunomodulation	immunomodulation	NN	NN	_	7	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	Expression	expression	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	role	role	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	PML	pml	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	normal	normal	JJ	JJ	_	10	amod	_	_
9	adult	adult	JJ	JJ	_	10	amod	_	_
10	hematopoiesis	hematopoiesis	NN	NN	_	1	nmod	_	_
11	:	:	:	:	_	1	punct	_	_
12	functional	functional	JJ	JJ	_	13	amod	_	_
13	interaction	interaction	NN	NN	_	1	dep	_	_
14	between	between	IN	IN	_	15	case	_	_
15	PML	pml	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Rb	rb	NN	NN	_	15	conj	_	_
18	proteins	protein	NNS	NNS	_	15	dep	_	_
19	in	in	IN	IN	_	20	case	_	_
20	erythropoiesis	erythropoiesis	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	expression	expression	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	PML	pml	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	2	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	investigated	investigate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	14	case	_	_
10	purified	purify	VBN	VBN	_	14	amod	_	_
11	early	early	JJ	JJ	_	14	amod	_	_
12	hematopoietic	hematopoietic	JJ	JJ	_	14	amod	_	_
13	progenitor	progenitor	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	8	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HPCs	hpc	NNS	NNS	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	induced	induce	VBN	VBN	_	14	acl	_	_
19	to	to	TO	TO	_	24	case	_	_
20	unilineage	unilineage	JJ	JJ	_	21	amod	_	_
21	erythroid	erythroid	JJ	JJ	_	24	amod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	granulocytic	granulocytic	JJ	JJ	_	21	conj	_	_
24	differentiation	differentiation	NN	NN	_	18	nmod	_	_
25	.	.	.	.	_	8	punct	_	_

1	PML	pml	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	15	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	protein	protein	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	15	punct	_	_
6	while	while	IN	IN	_	8	mark	_	_
7	barely	barely	RB	RB	_	8	dep	_	_
8	detectable	detectable	JJ	JJ	_	15	dep	_	_
9	in	in	IN	IN	_	11	case	_	_
10	quiescent	quiescent	JJ	JJ	_	11	amod	_	_
11	HPCs	hpc	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	15	punct	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	consistently	consistently	RB	RB	_	15	advmod	_	_
15	induced	induce	VBN	VBN	_	0	root	_	_
16	by	by	IN	IN	_	19	case	_	_
17	growth	growth	NN	NN	_	19	compound	_	_
18	factor	factor	NN	NN	_	19	compound	_	_
19	stimulation	stimulation	NN	NN	_	15	nmod	_	_
20	through	through	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	erythroid	erythroid	JJ	JJ	_	15	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	granulocytic	granulocytic	JJ	JJ	_	22	conj	_	_
25	lineage	lineage	NN	NN	_	22	dep	_	_
26	.	.	.	.	_	15	punct	_	_

1	Thereafter	thereafter	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	PML	pml	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	downmodulated	downmodulate	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	late	late	JJ	JJ	_	9	amod	_	_
8	granulocytic	granulocytic	JJ	JJ	_	9	amod	_	_
9	maturation	maturation	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	whereas	whereas	IN	IN	_	5	dep	_	_
12	it	it	PRP	PRP	_	15	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	sustainably	sustainably	RB	RB	_	15	advmod	_	_
15	expressed	express	VBN	VBN	_	5	parataxis	_	_
16	through	through	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	pathway	pathway	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	functional	functional	JJ	JJ	_	3	amod	_	_
3	studies	study	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	PML	pml	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	addition	addition	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	antisense	antisense	JJ	JJ	_	13	amod	_	_
13	oligomers	oligomer	NNS	NNS	_	10	nmod	_	_
14	targeting	target	VBG	VBG	_	13	acl	_	_
15	PML	pml	NN	NN	_	16	compound	_	_
16	mRNA	mrna	NN	NN	_	14	dobj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	alpha-PML	alpha-pml	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	early	early	JJ	JJ	_	4	amod	_	_
4	treatment	treatment	NN	NN	_	12	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	day	day	NN	NN	_	8	compound	_	_
7	0	0	CD	CD	_	8	nummod	_	_
8	HPCs	hpc	NNS	NNS	_	4	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	with	with	IN	IN	_	11	case	_	_
11	alpha-PML	alpha-pml	NN	NN	_	4	nmod	_	_
12	reduced	reduce	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	number	number	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	both	both	CC	CC	_	17	cc:preconj	_	_
17	erythroid	erythroid	JJ	JJ	_	20	amod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	granulocytic	granulocytic	JJ	JJ	_	17	conj	_	_
20	colonies	colony	NNS	NNS	_	14	nmod	_	_
21	,	,	,	,	_	12	punct	_	_
22	whereas	whereas	IN	IN	_	12	dep	_	_
23	late	late	JJ	JJ	_	24	amod	_	_
24	treatment	treatment	NN	NN	_	30	nsubj	_	_
25	(	(	-LRB-	-LRB-	_	28	punct	_	_
26	day	day	NN	NN	_	28	compound	_	_
27	5	5	CD	CD	_	28	nummod	_	_
28	culture	culture	NN	NN	_	24	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	reduced	reduce	VBD	VBD	_	12	parataxis	_	_
31	erythroid	erythroid	JJ	JJ	_	37	amod	_	_
32	,	,	,	,	_	31	punct	_	_
33	but	but	CC	CC	_	31	cc	_	_
34	not	not	RB	RB	_	31	conj	_	_
35	granulocytic	granulocytic	JJ	JJ	_	31	dep	_	_
36	,	,	,	,	_	37	punct	_	_
37	clonogenesis	clonogenesis	NN	NN	_	30	dobj	_	_
38	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	PML	pml	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	3	ccomp	_	_
8	for	for	IN	IN	_	10	case	_	_
9	early	early	JJ	JJ	_	10	amod	_	_
10	hematopoiesis	hematopoiesis	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	erythroid	erythroid	JJ	JJ	_	10	conj	_	_
13	,	,	,	,	_	12	punct	_	_
14	but	but	CC	CC	_	12	cc	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	granulocytic	granulocytic	JJ	JJ	_	12	conj	_	_
17	maturation	maturation	NN	NN	_	12	dep	_	_
18	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	PML	pml	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	normal	normal	JJ	JJ	_	8	amod	_	_
8	hematopoiesis	hematopoiesis	NN	NN	_	5	nmod	_	_
9	mimics	mimic	VBZ	VBZ	_	0	root	_	_
10	that	that	DT	DT	_	9	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	retinoblastoma	retinoblastoma	NN	NN	_	10	nmod	_	_
13	pRb	prb	NN	NN	_	12	dep	_	_
14	105	105	CD	CD	_	13	nummod	_	_
15	.	.	.	.	_	9	punct	_	_

1	Combined	combined	JJ	JJ	_	2	amod	_	_
2	treatment	treatment	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	HPCs	hpc	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	alpha-PML	alpha-pml	NN	NN	_	2	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	alpha-Rb	alpha-rb	NN	NN	_	9	compound	_	_
9	oligomers	oligomer	NNS	NNS	_	6	conj	_	_
10	inhibited	inhibit	VBD	VBD	_	0	root	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	PML	pml	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	Rb	rb	NN	NN	_	12	conj	_	_
15	protein	protein	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	12	dep	_	_
17	and	and	CC	CC	_	10	cc	_	_
18	completely	completely	RB	RB	_	19	advmod	_	_
19	blocked	block	VBD	VBD	_	10	conj	_	_
20	erythroid	erythroid	JJ	JJ	_	22	amod	_	_
21	colony	colony	NN	NN	_	22	compound	_	_
22	development	development	NN	NN	_	19	dobj	_	_
23	.	.	.	.	_	10	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	PML	pml	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	pRb	prb	NN	NN	_	3	conj	_	_
6	105	105	CD	CD	_	5	nummod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	co-immunoprecipitated	co-immunoprecipitate	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	lysates	lysate	NNS	NNS	_	8	nmod	_	_
12	derived	derive	VBN	VBN	_	11	acl	_	_
13	from	from	IN	IN	_	15	case	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	precursors	precursor	NNS	NNS	_	12	nmod	_	_
16	indicating	indicate	VBG	VBG	_	8	xcomp	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	this	this	DT	DT	_	20	det	_	_
19	functional	functional	JJ	JJ	_	20	amod	_	_
20	interaction	interaction	NN	NN	_	22	nsubj	_	_
21	may	may	MD	MD	_	22	aux	_	_
22	have	have	VB	VB	_	16	ccomp	_	_
23	a	a	DT	DT	_	25	det	_	_
24	biochemical	biochemical	JJ	JJ	_	25	amod	_	_
25	basis	basis	NN	NN	_	22	dobj	_	_
26	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	key	key	JJ	JJ	_	7	amod	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	3	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	PML	pml	NN	NN	_	3	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	early	early	JJ	JJ	_	12	amod	_	_
12	hematopoiesis	hematopoiesis	NN	NN	_	3	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	late	late	JJ	JJ	_	15	amod	_	_
15	erythropoiesis	erythropoiesis	NN	NN	_	12	conj	_	_
16	:	:	:	:	_	3	punct	_	_
17	the	the	DT	DT	_	19	det	_	_
18	latter	latter	JJ	JJ	_	19	amod	_	_
19	phenomenon	phenomenon	NN	NN	_	22	nsubj	_	_
20	may	may	MD	MD	_	22	aux	_	_
21	be	be	VB	VB	_	22	aux	_	_
22	related	related	JJ	JJ	_	3	parataxis	_	_
23	to	to	TO	TO	_	28	case	_	_
24	the	the	DT	DT	_	28	det	_	_
25	molecular	molecular	JJ	JJ	_	28	amod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	functional	functional	JJ	JJ	_	25	conj	_	_
28	interaction	interaction	NN	NN	_	22	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	PML	pml	NN	NN	_	28	nmod	_	_
31	with	with	IN	IN	_	32	case	_	_
32	pRb	prb	NN	NN	_	28	nmod	_	_
33	105	105	CD	CD	_	32	nummod	_	_
34	.	.	.	.	_	3	punct	_	_

1	PPARalpha	pparalpha	NN	NN	_	2	compound	_	_
2	activators	activator	NNS	NNS	_	3	nsubj	_	_
3	inhibit	inhibit	VBP	VBP	_	0	root	_	_
4	cytokine-induced	cytokine-induced	JJ	JJ	_	9	amod	_	_
5	vascular	vascular	JJ	JJ	_	9	amod	_	_
6	cell	cell	NN	NN	_	9	compound	_	_
7	adhesion	adhesion	NN	NN	_	9	compound	_	_
8	molecule-1	molecule-1	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	3	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	human	human	JJ	JJ	_	13	amod	_	_
12	endothelial	endothelial	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	BACKGROUND	background	NN	NN	_	15	dep	_	_
2	:	:	:	:	_	15	punct	_	_
3	Adhesion	adhesion	NN	NN	_	5	compound	_	_
4	molecule	molecule	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	15	nsubj	_	_
6	on	on	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	endothelial	endothelial	JJ	JJ	_	9	amod	_	_
9	cell	cell	NN	NN	_	13	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	EC	ec	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	surface	surface	NN	NN	_	5	nmod	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	critical	critical	JJ	JJ	_	0	root	_	_
16	for	for	IN	IN	_	18	case	_	_
17	leukocyte	leukocyte	NN	NN	_	18	compound	_	_
18	recruitment	recruitment	NN	NN	_	15	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	atherosclerotic	atherosclerotic	JJ	JJ	_	21	amod	_	_
21	lesions	lesion	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	Better	better	JJR	JJR	_	2	amod	_	_
2	understanding	understanding	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	regulation	regulation	NN	NN	_	2	nmod	_	_
6	of	of	IN	IN	_	8	case	_	_
7	adhesion	adhesion	NN	NN	_	8	compound	_	_
8	molecules	molecule	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	ECs	ec	NNS	NNS	_	8	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	provide	provide	VB	VB	_	0	root	_	_
13	important	important	JJ	JJ	_	14	amod	_	_
14	insight	insight	NN	NN	_	12	dobj	_	_
15	into	into	IN	IN	_	17	case	_	_
16	plaque	plaque	NN	NN	_	17	compound	_	_
17	formation	formation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	12	punct	_	_

1	Peroxisome	peroxisome	NN	NN	_	3	compound	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	3	amod	_	_
3	receptor-alpha	receptor-alpha	NN	NN	_	16	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PPARalpha	pparalpha	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	a	a	DT	DT	_	9	det	_	_
9	member	member	NN	NN	_	3	appos	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
13	receptor	receptor	NN	NN	_	14	compound	_	_
14	family	family	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	16	punct	_	_
16	regulates	regulate	VBZ	VBZ	_	0	root	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	16	nmod	_	_
21	to	to	TO	TO	_	24	case	_	_
22	certain	certain	JJ	JJ	_	24	amod	_	_
23	fatty	fatty	JJ	JJ	_	24	amod	_	_
24	acids	acid	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	fibric	fibric	JJ	JJ	_	28	amod	_	_
27	acid	acid	NN	NN	_	28	compound	_	_
28	derivatives	derivative	NNS	NNS	_	24	conj	_	_
29	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	present	present	JJ	JJ	_	3	amod	_	_
3	study	study	NN	NN	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	PPARalpha	pparalpha	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	ECs	ec	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	their	they	PRP$	PRP$	_	12	nmod:poss	_	_
12	regulation	regulation	NN	NN	_	6	conj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	vascular	vascular	JJ	JJ	_	17	amod	_	_
15	cell	cell	NN	NN	_	17	compound	_	_
16	adhesion	adhesion	NN	NN	_	17	compound	_	_
17	molecule-1	molecule-1	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	VCAM-1	vcam-1	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	4	punct	_	_

1	METHODS	method	NNS	NNS	_	6	nsubj	_	_
2	AND	and	CC	CC	_	1	cc	_	_
3	RESULTS	result	NNS	NNS	_	1	conj	_	_
4	:	:	:	:	_	6	punct	_	_
5	Immunohistochemistry	immunohistochemistry	NN	NN	_	6	nsubj	_	_
6	revealed	reveal	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	carotid	carotid	NN	NN	_	11	compound	_	_
10	artery	artery	NN	NN	_	11	compound	_	_
11	ECs	ec	NNS	NNS	_	12	nsubj	_	_
12	express	express	VBP	VBP	_	6	ccomp	_	_
13	PPARalpha	pparalpha	NN	NN	_	12	dobj	_	_
14	.	.	.	.	_	6	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	cultured	culture	VBN	VBN	_	5	amod	_	_
4	human	human	JJ	JJ	_	5	amod	_	_
5	ECs	ec	NNS	NNS	_	1	nmod	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	PPARalpha	pparalpha	NN	NN	_	9	compound	_	_
9	activators	activator	NNS	NNS	_	1	nmod	_	_
10	fenofibrate	fenofibrate	NN	NN	_	9	dep	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	WY14643	wy14643	NN	NN	_	10	conj	_	_
13	inhibited	inhibit	VBD	VBD	_	0	root	_	_
14	TNF-alpha-induced	tnf-alpha-induced	JJ	JJ	_	15	amod	_	_
15	VCAM-1	vcam-1	NN	NN	_	13	dobj	_	_
16	in	in	IN	IN	_	21	case	_	_
17	a	a	DT	DT	_	21	det	_	_
18	time-	time-	NN	NN	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	concentration-dependent	concentration-dependent	JJ	JJ	_	18	conj	_	_
21	manner	manner	NN	NN	_	13	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	an	a	DT	DT	_	24	det	_	_
24	effect	effect	NN	NN	_	21	appos	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	seen	see	VBN	VBN	_	24	acl	_	_
27	with	with	IN	IN	_	29	case	_	_
28	PPARgamma	ppargamma	NN	NN	_	29	compound	_	_
29	activators	activator	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	13	punct	_	_

1	Both	both	DT	DT	_	3	det	_	_
2	PPARalpha	pparalpha	NN	NN	_	3	compound	_	_
3	activators	activator	NNS	NNS	_	4	nsubj	_	_
4	decreased	decrease	VBD	VBD	_	0	root	_	_
5	cytokine-induced	cytokine-induced	JJ	JJ	_	8	amod	_	_
6	VCAM-1	vcam-1	NN	NN	_	8	compound	_	_
7	mRNA	mrna	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	4	dobj	_	_
9	without	without	IN	IN	_	10	mark	_	_
10	altering	alter	VBG	VBG	_	4	advcl	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	mRNA	mrna	NN	NN	_	13	compound	_	_
13	half-life	half-life	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	Transient	transient	JJ	JJ	_	2	amod	_	_
2	transfection	transfection	NN	NN	_	13	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	deletional	deletional	JJ	JJ	_	7	amod	_	_
5	VCAM-1	vcam-1	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	constructs	construct	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	electrophoretic	electrophoretic	JJ	JJ	_	12	amod	_	_
10	mobility	mobility	NN	NN	_	12	compound	_	_
11	shift	shift	NN	NN	_	12	compound	_	_
12	assays	assay	NNS	NNS	_	7	conj	_	_
13	suggest	suggest	VBP	VBP	_	0	root	_	_
14	that	that	IN	IN	_	16	mark	_	_
15	fenofibrate	fenofibrate	NN	NN	_	16	nsubj	_	_
16	inhibits	inhibit	VBZ	VBZ	_	13	ccomp	_	_
17	VCAM-1	vcam-1	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	part	part	NN	NN	_	16	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	inhibiting	inhibit	VBG	VBG	_	16	advcl	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	22	dobj	_	_
24	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	PPARalpha	pparalpha	NN	NN	_	4	compound	_	_
4	activators	activator	NNS	NNS	_	6	nsubj	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	reduced	reduce	VBD	VBD	_	0	root	_	_
7	adhesion	adhesion	NN	NN	_	6	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	U937	u937	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	cultured	culture	VBN	VBN	_	14	amod	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	ECs	ec	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	5	dep	_	_
2	:	:	:	:	_	5	punct	_	_
3	Human	human	JJ	JJ	_	4	amod	_	_
4	ECs	ec	NNS	NNS	_	5	nsubj	_	_
5	express	express	VBP	VBP	_	0	root	_	_
6	PPARalpha	pparalpha	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	6	punct	_	_
8	a	a	DT	DT	_	11	det	_	_
9	potentially	potentially	RB	RB	_	10	advmod	_	_
10	important	important	JJ	JJ	_	11	amod	_	_
11	regulator	regulator	NN	NN	_	6	appos	_	_
12	of	of	IN	IN	_	13	case	_	_
13	atherogenesis	atherogenesis	NN	NN	_	11	nmod	_	_
14	through	through	IN	IN	_	17	case	_	_
15	its	its	PRP$	PRP$	_	17	nmod:poss	_	_
16	transcriptional	transcriptional	JJ	JJ	_	17	amod	_	_
17	control	control	NN	NN	_	5	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	VCAM-1	vcam-1	NN	NN	_	21	compound	_	_
20	gene	gene	NN	NN	_	21	compound	_	_
21	expression	expression	NN	NN	_	17	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Such	such	JJ	JJ	_	2	amod	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	have	have	VBP	VBP	_	0	root	_	_
5	implications	implication	NNS	NNS	_	4	dobj	_	_
6	regarding	regard	VBG	VBG	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	clinical	clinical	JJ	JJ	_	9	amod	_	_
9	use	use	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	lipid-lowering	lipid-lowering	JJ	JJ	_	12	amod	_	_
12	agents	agent	NNS	NNS	_	9	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	like	like	IN	IN	_	16	case	_	_
15	fibric	fibric	JJ	JJ	_	16	amod	_	_
16	acids	acid	NNS	NNS	_	4	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	20	nsubj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	activate	activate	VB	VB	_	16	acl:relcl	_	_
21	PPARalpha	pparalpha	NN	NN	_	20	dobj	_	_
22	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	intracellular	intracellular	JJ	JJ	_	3	amod	_	_
3	parasite	parasite	NN	NN	_	6	nsubj	_	_
4	Theileria	theileria	FW	FW	_	5	compound	_	_
5	parva	parva	FW	FW	_	3	dep	_	_
6	protects	protect	VBZ	VBZ	_	0	root	_	_
7	infected	infected	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	cells	cell	NNS	NNS	_	6	dobj	_	_
10	from	from	IN	IN	_	11	case	_	_
11	apoptosis	apoptosis	NN	NN	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	Parasites	parasite	NNS	NNS	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	evolved	evolve	VBN	VBN	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	plethora	plethora	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	strategies	strategy	NNS	NNS	_	5	nmod	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	ensure	ensure	VB	VB	_	3	advcl	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	survival	survival	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	intracellular	intracellular	JJ	JJ	_	3	amod	_	_
3	parasite	parasite	NN	NN	_	6	nsubj	_	_
4	Theileria	theileria	FW	FW	_	5	compound	_	_
5	parva	parva	FW	FW	_	3	dep	_	_
6	secures	secure	VBZ	VBZ	_	0	root	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	propagation	propagation	NN	NN	_	6	dobj	_	_
9	and	and	CC	CC	_	6	cc	_	_
10	spreads	spread	VBZ	VBZ	_	6	conj	_	_
11	through	through	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	infected	infected	JJ	JJ	_	14	amod	_	_
14	animal	animal	NN	NN	_	10	nmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	infecting	infect	VBG	VBG	_	10	advcl	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	transforming	transform	VBG	VBG	_	16	conj	_	_
19	T	t	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	16	dobj	_	_
21	,	,	,	,	_	16	punct	_	_
22	inducing	induce	VBG	VBG	_	16	conj	_	_
23	their	they	PRP$	PRP$	_	25	nmod:poss	_	_
24	continuous	continuous	JJ	JJ	_	25	amod	_	_
25	proliferation	proliferation	NN	NN	_	22	dobj	_	_
26	and	and	CC	CC	_	16	cc	_	_
27	rendering	render	VBG	VBG	_	16	conj	_	_
28	them	they	PRP	PRP	_	29	nsubj	_	_
29	metastatic	metastatic	JJ	JJ	_	27	xcomp	_	_
30	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	previous	previous	JJ	JJ	_	3	amod	_	_
3	work	work	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	have	have	VBP	VBP	_	7	aux	_	_
7	shown	show	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	the	the	DT	DT	_	10	det	_	_
10	parasite	parasite	NN	NN	_	11	nsubj	_	_
11	induces	induce	VBZ	VBZ	_	7	ccomp	_	_
12	constitutive	constitutive	JJ	JJ	_	13	amod	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	transcription	transcription	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	nmod	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	11	punct	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	inducing	induce	VBG	VBG	_	11	advcl	_	_
22	the	the	DT	DT	_	24	det	_	_
23	constitutive	constitutive	JJ	JJ	_	24	amod	_	_
24	degradation	degradation	NN	NN	_	21	dobj	_	_
25	of	of	IN	IN	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	cytoplasmic	cytoplasmic	JJ	JJ	_	28	amod	_	_
28	inhibitors	inhibitor	NNS	NNS	_	24	nmod	_	_
29	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	biological	biological	JJ	JJ	_	3	amod	_	_
3	significance	significance	NN	NN	_	18	nsubjpass	_	_
4	of	of	IN	IN	_	6	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	T.	t.	FW	FW	_	10	compound	_	_
9	parva-infected	parva-infected	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	18	punct	_	_
12	however	however	RB	RB	_	18	advmod	_	_
13	,	,	,	,	_	18	punct	_	_
14	has	have	VBZ	VBZ	_	18	aux	_	_
15	not	not	RB	RB	_	18	neg	_	_
16	yet	yet	RB	RB	_	18	advmod	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	defined	define	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Cells	cell	NNS	NNS	_	11	nsubj	_	_
2	that	that	WDT	WDT	_	5	nsubjpass	_	_
3	have	have	VBP	VBP	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	transformed	transform	VBN	VBN	_	1	acl:relcl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	viruses	virus	NNS	NNS	_	5	nmod	_	_
8	or	or	CC	CC	_	7	cc	_	_
9	oncogenes	oncogene	NNS	NNS	_	7	conj	_	_
10	can	can	MD	MD	_	11	aux	_	_
11	persist	persist	VB	VB	_	0	root	_	_
12	only	only	RB	RB	_	15	advmod	_	_
13	if	if	IN	IN	_	15	mark	_	_
14	they	they	PRP	PRP	_	15	nsubj	_	_
15	manage	manage	VBP	VBP	_	11	advcl	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	avoid	avoid	VB	VB	_	15	xcomp	_	_
18	destruction	destruction	NN	NN	_	17	dobj	_	_
19	by	by	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	apoptotic	apoptotic	JJ	JJ	_	22	amod	_	_
22	mechanisms	mechanism	NNS	NNS	_	17	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubjpass	_	_
24	are	be	VBP	VBP	_	25	auxpass	_	_
25	activated	activate	VBN	VBN	_	22	acl:relcl	_	_
26	on	on	IN	IN	_	27	case	_	_
27	transformation	transformation	NN	NN	_	25	nmod	_	_
28	and	and	CC	CC	_	25	cc	_	_
29	that	that	WDT	WDT	_	30	nsubj	_	_
30	contribute	contribute	VBP	VBP	_	25	conj	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	maintain	maintain	VB	VB	_	30	xcomp	_	_
33	cellular	cellular	JJ	JJ	_	34	amod	_	_
34	homeostasis	homeostasis	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	parasite-induced	parasite-induced	JJ	JJ	_	7	amod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	8	nsubj	_	_
8	plays	play	VBZ	VBZ	_	3	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	crucial	crucial	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	survival	survival	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	19	case	_	_
16	T.	t.	FW	FW	_	19	compound	_	_
17	parva-transformed	parva-transformed	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	by	by	IN	IN	_	21	mark	_	_
21	conveying	convey	VBG	VBG	_	8	advcl	_	_
22	protection	protection	NN	NN	_	21	dobj	_	_
23	against	against	IN	IN	_	26	case	_	_
24	an	a	DT	DT	_	26	det	_	_
25	apoptotic	apoptotic	JJ	JJ	_	26	amod	_	_
26	signal	signal	NN	NN	_	22	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	accompanies	accompany	VBZ	VBZ	_	26	acl:relcl	_	_
29	parasite-mediated	parasite-mediated	JJ	JJ	_	30	amod	_	_
30	transformation	transformation	NN	NN	_	28	dobj	_	_
31	.	.	.	.	_	3	punct	_	_

1	Consequently	consequently	RB	RB	_	30	advmod	_	_
2	,	,	,	,	_	30	punct	_	_
3	inhibition	inhibition	NN	NN	_	30	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	translocation	translocation	NN	NN	_	5	dep	_	_
8	and	and	CC	CC	_	3	cc	_	_
9	the	the	DT	DT	_	10	det	_	_
10	expression	expression	NN	NN	_	3	conj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	dominant	dominant	JJ	JJ	_	15	amod	_	_
13	negative	negative	JJ	JJ	_	15	amod	_	_
14	mutant	mutant	JJ	JJ	_	15	amod	_	_
15	forms	form	NNS	NNS	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	components	component	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	22	compound	_	_
21	activation	activation	NN	NN	_	22	compound	_	_
22	pathway	pathway	NN	NN	_	17	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	such	such	JJ	JJ	_	26	case	_	_
25	as	as	IN	IN	_	24	mwe	_	_
26	IkappaBalpha	ikappabalpha	NN	NN	_	22	nmod	_	_
27	or	or	CC	CC	_	26	cc	_	_
28	p65	p65	NN	NN	_	26	conj	_	_
29	,	,	,	,	_	30	punct	_	_
30	prompt	prompt	VBP	VBP	_	0	root	_	_
31	rapid	rapid	JJ	JJ	_	32	amod	_	_
32	apoptosis	apoptosis	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	T.	t.	FW	FW	_	37	compound	_	_
35	parva-transformed	parva-transformed	JJ	JJ	_	37	amod	_	_
36	T	t	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	32	nmod	_	_
38	.	.	.	.	_	30	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	offer	offer	VBP	VBP	_	0	root	_	_
4	important	important	JJ	JJ	_	5	amod	_	_
5	insights	insight	NNS	NNS	_	3	dobj	_	_
6	into	into	IN	IN	_	9	case	_	_
7	parasite	parasite	JJ	JJ	_	9	amod	_	_
8	survival	survival	NN	NN	_	9	compound	_	_
9	strategies	strategy	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	3	cc	_	_
11	demonstrate	demonstrate	VBP	VBP	_	3	conj	_	_
12	that	that	IN	IN	_	20	mark	_	_
13	parasite-induced	parasite-induced	JJ	JJ	_	16	amod	_	_
14	constitutive	constitutive	JJ	JJ	_	16	amod	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	20	nsubj	_	_
17	is	be	VBZ	VBZ	_	20	cop	_	_
18	an	a	DT	DT	_	20	det	_	_
19	essential	essential	JJ	JJ	_	20	amod	_	_
20	step	step	NN	NN	_	11	ccomp	_	_
21	in	in	IN	IN	_	22	mark	_	_
22	maintaining	maintain	VBG	VBG	_	20	acl	_	_
23	the	the	DT	DT	_	25	det	_	_
24	transformed	transform	VBN	VBN	_	25	amod	_	_
25	phenotype	phenotype	NN	NN	_	22	dobj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	infected	infected	JJ	JJ	_	29	amod	_	_
29	cells	cell	NNS	NNS	_	25	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Downregulation	downregulation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	Wilms	wilms	NN	NN	_	6	nmod:poss	_	_
4	'	'	POS	POS	_	6	case	_	_
5	tumor	tumor	NN	NN	_	6	compound	_	_
6	gene	gene	NN	NN	_	1	nmod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	WT1	wt1	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	is	be	VBZ	VBZ	_	13	cop	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	a	a	DT	DT	_	13	det	_	_
13	prerequisite	prerequisite	NN	NN	_	0	root	_	_
14	for	for	IN	IN	_	15	case	_	_
15	erythroid	erythroid	JJ	JJ	_	13	nmod	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	megakaryocytic	megakaryocytic	JJ	JJ	_	15	conj	_	_
18	differentiation	differentiation	NN	NN	_	15	dep	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	leukemic	leukemic	JJ	JJ	_	24	amod	_	_
22	cell	cell	NN	NN	_	24	compound	_	_
23	line	line	NN	NN	_	24	compound	_	_
24	K562	k562	NN	NN	_	15	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Wilms	wilms	NN	NN	_	5	nmod:poss	_	_
3	'	'	POS	POS	_	5	case	_	_
4	tumor	tumor	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	WT1	wt1	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	encodes	encode	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	12	det	_	_
11	transcription	transcription	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	zinc	zinc	NN	NN	_	17	compound	_	_
16	finger	finger	NN	NN	_	17	compound	_	_
17	type	type	NN	NN	_	12	nmod	_	_
18	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	high	high	JJ	JJ	_	3	amod	_	_
3	expression	expression	NN	NN	_	8	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	WT1	wt1	NN	NN	_	3	nmod	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	detected	detect	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	range	range	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	acute	acute	JJ	JJ	_	14	amod	_	_
14	leukemias	leukemia	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	WT1	wt1	NN	NN	_	19	nsubjpass	_	_
18	is	be	VBZ	VBZ	_	19	auxpass	_	_
19	downregulated	downregulate	VBN	VBN	_	8	conj	_	_
20	during	during	IN	IN	_	22	case	_	_
21	induced	induce	VBN	VBN	_	22	amod	_	_
22	differentiation	differentiation	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	27	case	_	_
24	some	some	DT	DT	_	27	det	_	_
25	leukemic	leukemic	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lines	line	NNS	NNS	_	22	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Overexpression	overexpression	NN	NN	_	9	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	WT1	wt1	NN	NN	_	1	nmod	_	_
4	in	in	IN	IN	_	8	case	_	_
5	some	some	DT	DT	_	8	det	_	_
6	myeloid	myeloid	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	lines	line	NNS	NNS	_	1	nmod	_	_
9	confers	confer	VBZ	VBZ	_	0	root	_	_
10	resistance	resistance	NN	NN	_	9	dobj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	differentiation	differentiation	NN	NN	_	13	compound	_	_
13	induction	induction	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	observations	observation	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	13	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	high	high	JJ	JJ	_	8	amod	_	_
7	WT1	wt1	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	13	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	hematopoietic	hematopoietic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	cop	_	_
13	incompatible	incompatible	JJ	JJ	_	3	ccomp	_	_
14	with	with	IN	IN	_	15	case	_	_
15	differentiation	differentiation	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	15	nmod	_	_
4	,	,	,	,	_	15	punct	_	_
5	each	each	DT	DT	_	15	nsubjpass	_	_
6	of	of	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	four	four	CD	CD	_	10	nummod	_	_
9	different	different	JJ	JJ	_	10	amod	_	_
10	isoforms	isoform	NNS	NNS	_	5	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	WT1	wt1	NN	NN	_	10	nmod	_	_
13	was	be	VBD	VBD	_	15	auxpass	_	_
14	constitutively	constitutively	RB	RB	_	15	advmod	_	_
15	overexpressed	overexpress	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	leukemic	leukemic	JJ	JJ	_	21	amod	_	_
19	cell	cell	NN	NN	_	21	compound	_	_
20	line	line	NN	NN	_	21	compound	_	_
21	K562	k562	NN	NN	_	15	nmod	_	_
22	.	.	.	.	_	15	punct	_	_

1	K562	k562	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	3	nsubj	_	_
3	express	express	VBP	VBP	_	0	root	_	_
4	endogenous	endogenous	JJ	JJ	_	5	amod	_	_
5	WT1	wt1	NN	NN	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	downregulated	downregulate	VBN	VBN	_	5	acl:relcl	_	_
10	as	as	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	response	response	NN	NN	_	9	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	induced	induce	VBN	VBN	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	along	along	IN	IN	_	21	case	_	_
17	the	the	DT	DT	_	21	det	_	_
18	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	megakaryocytic	megakaryocytic	JJ	JJ	_	18	conj	_	_
21	pathways	pathway	NNS	NNS	_	9	nmod	_	_
22	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	20	mark	_	_
5	a	a	DT	DT	_	8	det	_	_
6	forced	forced	JJ	JJ	_	8	amod	_	_
7	exogenous	exogenous	JJ	JJ	_	8	amod	_	_
8	expression	expression	NN	NN	_	20	nsubj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	four	four	CD	CD	_	13	nummod	_	_
12	different	different	JJ	JJ	_	13	amod	_	_
13	isoforms	isoform	NNS	NNS	_	8	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	WT1	wt1	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	K562	k562	NN	NN	_	15	nmod	_	_
18	does	do	VBZ	VBZ	_	20	aux	_	_
19	not	not	RB	RB	_	20	neg	_	_
20	affect	affect	VB	VB	_	3	ccomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	differentiation	differentiation	NN	NN	_	23	compound	_	_
23	response	response	NN	NN	_	20	dobj	_	_
24	,	,	,	,	_	20	punct	_	_
25	as	as	IN	IN	_	26	mark	_	_
26	judged	judge	VBN	VBN	_	20	advcl	_	_
27	by	by	IN	IN	_	28	case	_	_
28	accumulation	accumulation	NN	NN	_	26	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	hemoglobin	hemoglobin	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	response	response	NN	NN	_	30	nmod	_	_
33	to	to	TO	TO	_	34	case	_	_
34	hemin	hemin	NN	NN	_	32	nmod	_	_
35	or	or	CC	CC	_	28	cc	_	_
36	the	the	DT	DT	_	37	det	_	_
37	expression	expression	NN	NN	_	28	conj	_	_
38	of	of	IN	IN	_	42	case	_	_
39	megakaryocytic	megakaryocytic	JJ	JJ	_	42	amod	_	_
40	cell	cell	NN	NN	_	42	compound	_	_
41	surface	surface	NN	NN	_	42	compound	_	_
42	markers	marker	NNS	NNS	_	37	nmod	_	_
43	in	in	IN	IN	_	44	case	_	_
44	response	response	NN	NN	_	42	nmod	_	_
45	to	to	TO	TO	_	46	case	_	_
46	12-O-tetradecanoylphorbol-13-acetate	12-o-tetradecanoylphorbol-13-acetate	NN	NN	_	44	nmod	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	TPA	tpa	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	16	mark	_	_
4	downregulation	downregulation	NN	NN	_	16	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	WT1	wt1	NN	NN	_	4	nmod	_	_
7	during	during	IN	IN	_	9	case	_	_
8	induced	induce	VBN	VBN	_	9	amod	_	_
9	differentiation	differentiation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	K562	k562	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	not	not	RB	RB	_	16	neg	_	_
15	a	a	DT	DT	_	16	det	_	_
16	prerequisite	prerequisite	NN	NN	_	2	ccomp	_	_
17	for	for	IN	IN	_	18	case	_	_
18	erythroid	erythroid	JJ	JJ	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	megakaryocytic	megakaryocytic	JJ	JJ	_	18	conj	_	_
21	differentiation	differentiation	NN	NN	_	18	dep	_	_
22	of	of	IN	IN	_	24	case	_	_
23	these	these	DT	DT	_	24	det	_	_
24	cells	cell	NNS	NNS	_	18	nmod	_	_
25	.	.	.	.	_	2	punct	_	_

1	Signal	signal	NN	NN	_	3	compound	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	normal	normal	JJ	JJ	_	7	amod	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
8	stimulated	stimulate	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	mediators	mediator	NNS	NNS	_	10	conj	_	_
13	:	:	:	:	_	3	punct	_	_
14	comparative	comparative	JJ	JJ	_	15	amod	_	_
15	study	study	NN	NN	_	3	dep	_	_
16	with	with	IN	IN	_	19	case	_	_
17	normal	normal	JJ	JJ	_	19	amod	_	_
18	human	human	JJ	JJ	_	19	amod	_	_
19	neutrophils	neutrophil	NNS	NNS	_	15	nmod	_	_
20	or	or	CC	CC	_	19	cc	_	_
21	transformed	transform	VBN	VBN	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	19	conj	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	the	the	DT	DT	_	26	det	_	_
25	putative	putative	JJ	JJ	_	26	amod	_	_
26	roles	role	NNS	NNS	_	15	conj	_	_
27	in	in	IN	IN	_	28	case	_	_
28	functionality	functionality	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	biology	biology	NN	NN	_	28	conj	_	_
32	.	.	.	.	_	3	punct	_	_

1	Granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	3	amod	_	_
2	colony-stimulating	colony-stimulating	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	13	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GM-CSF	gm-csf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	interleukin	interleukin	NN	NN	_	3	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL	il	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	-3	-3	CD	CD	_	8	nummod	_	_
13	induced	induce	VBD	VBD	_	0	root	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	92-kDa	92-kda	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	normal	normal	JJ	JJ	_	22	amod	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	monocytes	monocyte	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	13	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	this	this	DT	DT	_	5	det	_	_
4	92-kDa	92-kda	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	2	dobj	_	_
6	as	as	IN	IN	_	7	case	_	_
7	STAT5	stat5	NN	NN	_	2	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	7	cc	_	_
10	not	not	RB	RB	_	12	neg	_	_
11	as	as	IN	IN	_	12	case	_	_
12	STATs1	stats1	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	12	punct	_	_
14	3	3	CD	CD	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	and	and	CC	CC	_	12	cc	_	_
17	6	6	CD	CD	_	12	conj	_	_
18	nor	nor	CC	CC	_	12	cc	_	_
19	c-fes	c-fes	NN	NN	_	12	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	vav	vav	NN	NN	_	23	compound	_	_
22	protooncogene	protooncogene	NN	NN	_	23	compound	_	_
23	products	product	NNS	NNS	_	19	conj	_	_
24	,	,	,	,	_	2	punct	_	_
25	and	and	CC	CC	_	2	cc	_	_
26	demonstrated	demonstrate	VBD	VBD	_	2	conj	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	translocation	translocation	NN	NN	_	26	dobj	_	_
29	to	to	TO	TO	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	nucleus	nucleus	NN	NN	_	28	nmod	_	_
32	,	,	,	,	_	28	punct	_	_
33	enhancement	enhancement	NN	NN	_	28	conj	_	_
34	of	of	IN	IN	_	38	case	_	_
35	specific	specific	JJ	JJ	_	38	amod	_	_
36	DNA	dna	NN	NN	_	38	compound	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	capacity	capacity	NN	NN	_	33	nmod	_	_
39	,	,	,	,	_	28	punct	_	_
40	and	and	CC	CC	_	28	cc	_	_
41	potentiation	potentiation	NN	NN	_	28	conj	_	_
42	of	of	IN	IN	_	44	case	_	_
43	trancriptional	trancriptional	JJ	JJ	_	44	amod	_	_
44	activity	activity	NN	NN	_	41	nmod	_	_
45	by	by	IN	IN	_	46	case	_	_
46	GM-CSF	gm-csf	NN	NN	_	41	nmod	_	_
47	.	.	.	.	_	2	punct	_	_

1	N-formyl-methionyl-leucyl-phenylalanine	n-formyl-methionyl-leucyl-phenylalanine	NN	NN	_	12	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	FMLP	fmlp	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	phorbol	phorbol	NN	NN	_	8	compound	_	_
7	myristate	myristate	NN	NN	_	8	compound	_	_
8	acetate	acetate	NN	NN	_	1	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PMA	pma	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	induced	induce	VBD	VBD	_	0	root	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	42-	42-	CD	CD	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	44-kDa	44-kda	JJ	JJ	_	19	amod	_	_
19	proteins	protein	NNS	NNS	_	16	conj	_	_
20	,	,	,	,	_	16	punct	_	_
21	which	which	WDT	WDT	_	23	nsubjpass	_	_
22	were	be	VBD	VBD	_	23	auxpass	_	_
23	identified	identify	VBN	VBN	_	16	acl:relcl	_	_
24	as	as	IN	IN	_	27	case	_	_
25	extracellular	extracellular	JJ	JJ	_	27	amod	_	_
26	signal-regulated	signal-regulated	JJ	JJ	_	27	amod	_	_
27	kinase	kinase	NN	NN	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	ERK	erk	NN	NN	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	,	,	,	,	_	27	punct	_	_
32	in	in	IN	IN	_	34	case	_	_
33	human	human	JJ	JJ	_	34	amod	_	_
34	monocytes	monocyte	NNS	NNS	_	27	nmod	_	_
35	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	marked	marked	JJ	JJ	_	3	amod	_	_
3	contrast	contrast	NN	NN	_	13	nmod	_	_
4	to	to	TO	TO	_	5	case	_	_
5	neutrophils	neutrophil	NNS	NNS	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	MO7e	mo7e	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	conj	_	_
9	,	,	,	,	_	13	punct	_	_
10	GM-CSF	gm-csf	NN	NN	_	13	nsubj	_	_
11	did	do	VBD	VBD	_	13	aux	_	_
12	not	not	RB	RB	_	13	neg	_	_
13	induce	induce	VB	VB	_	0	root	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	activation	activation	NN	NN	_	15	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	ERK	erk	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	Among	among	IN	IN	_	4	case	_	_
2	upstream	upstream	JJ	JJ	_	4	amod	_	_
3	signaling	signal	VBG	VBG	_	4	amod	_	_
4	molecules	molecule	NNS	NNS	_	11	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	ERK	erk	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	11	punct	_	_
8	Shc	shc	NN	NN	_	11	nsubjpass	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	constitutively	constitutively	RB	RB	_	11	advmod	_	_
11	associated	associate	VBN	VBN	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Grb2	grb2	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	11	cc	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	tyrosine-phosphorylated	tyrosine-phosphorylate	VBN	VBN	_	11	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	GM-CSF	gm-csf	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	FMLP	fmlp	NN	NN	_	19	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	and	and	CC	CC	_	11	cc	_	_
24	Sos1	sos1	NN	NN	_	29	nsubjpass	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	c-Raf-1	c-raf-1	NN	NN	_	24	conj	_	_
27	were	be	VBD	VBD	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	phosphorylated	phosphorylate	VBN	VBN	_	11	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	GM-CSF	gm-csf	NN	NN	_	29	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	IL-3	il-3	NN	NN	_	31	conj	_	_
34	,	,	,	,	_	31	punct	_	_
35	TNF	tnf	NN	NN	_	31	conj	_	_
36	,	,	,	,	_	31	punct	_	_
37	and	and	CC	CC	_	31	cc	_	_
38	FMLP	fmlp	NN	NN	_	31	conj	_	_
39	in	in	IN	IN	_	40	case	_	_
40	monocytes	monocyte	NNS	NNS	_	31	nmod	_	_
41	,	,	,	,	_	11	punct	_	_
42	whereas	whereas	IN	IN	_	11	dep	_	_
43	all	all	PDT	PDT	_	46	det:predet	_	_
44	these	these	DT	DT	_	46	det	_	_
45	signaling	signal	VBG	VBG	_	46	amod	_	_
46	molecules	molecule	NNS	NNS	_	48	nsubjpass	_	_
47	were	be	VBD	VBD	_	48	auxpass	_	_
48	affected	affect	VBN	VBN	_	11	parataxis	_	_
49	and/or	and/or	CC	CC	_	48	cc	_	_
50	utilized	utilize	VBN	VBN	_	48	conj	_	_
51	by	by	IN	IN	_	52	case	_	_
52	GM-CSF	gm-csf	NN	NN	_	48	nmod	_	_
53	in	in	IN	IN	_	55	case	_	_
54	MO7e	mo7e	NN	NN	_	55	compound	_	_
55	cells	cell	NNS	NNS	_	52	nmod	_	_
56	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	neutrophils	neutrophil	NNS	NNS	_	2	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	p38	p38	NN	NN	_	9	nsubjpass	_	_
7	was	be	VBD	VBD	_	9	auxpass	_	_
8	constitutively	constitutively	RB	RB	_	9	advmod	_	_
9	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	agonist-dependent	agonist-dependent	JJ	JJ	_	12	amod	_	_
12	phosphorylation	phosphorylation	NN	NN	_	17	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	activation	activation	NN	NN	_	12	conj	_	_
15	was	be	VBD	VBD	_	17	auxpass	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	detected	detect	VBN	VBN	_	9	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	human	human	JJ	JJ	_	20	amod	_	_
20	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	9	punct	_	_

1	Superoxide	superoxide	NN	NN	_	2	compound	_	_
2	release	release	NN	NN	_	7	nsubjpass	_	_
3	stimulated	stimulate	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	5	case	_	_
5	FMLP	fmlp	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	inhibited	inhibit	VBN	VBN	_	0	root	_	_
8	partially	partially	RB	RB	_	7	advmod	_	_
9	by	by	IN	IN	_	10	case	_	_
10	PD98059	pd98059	NN	NN	_	7	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	SB203580	sb203580	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	a	a	DT	DT	_	16	det	_	_
15	specific	specific	JJ	JJ	_	16	amod	_	_
16	inhibitor	inhibitor	NN	NN	_	10	appos	_	_
17	of	of	IN	IN	_	18	case	_	_
18	ERK	erk	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	p38	p38	NN	NN	_	18	conj	_	_
21	pathway	pathway	NN	NN	_	18	dep	_	_
22	,	,	,	,	_	7	punct	_	_
23	and	and	CC	CC	_	7	cc	_	_
24	was	be	VBD	VBD	_	27	auxpass	_	_
25	almost	almost	RB	RB	_	26	advmod	_	_
26	completely	completely	RB	RB	_	27	advmod	_	_
27	inhibited	inhibit	VBN	VBN	_	7	conj	_	_
28	by	by	IN	IN	_	30	case	_	_
29	the	the	DT	DT	_	30	det	_	_
30	combination	combination	NN	NN	_	27	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	both	both	DT	DT	_	33	det	_	_
33	inhibitors	inhibitor	NNS	NNS	_	30	nmod	_	_
34	,	,	,	,	_	7	punct	_	_
35	whereas	whereas	IN	IN	_	7	dep	_	_
36	PMA-induced	pma-induced	JJ	JJ	_	38	amod	_	_
37	superoxide	superoxide	NN	NN	_	38	compound	_	_
38	release	release	NN	NN	_	40	nsubj	_	_
39	was	be	VBD	VBD	_	40	cop	_	_
40	resistant	resistant	JJ	JJ	_	7	parataxis	_	_
41	to	to	TO	TO	_	44	case	_	_
42	these	these	DT	DT	_	44	det	_	_
43	two	two	CD	CD	_	44	nummod	_	_
44	inhibitors	inhibitor	NNS	NNS	_	40	nmod	_	_
45	in	in	IN	IN	_	46	case	_	_
46	monocytes	monocyte	NNS	NNS	_	44	nmod	_	_
47	.	.	.	.	_	7	punct	_	_

1	PD98059	pd98059	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	GM-CSF-dependent	gm-csf-dependent	JJ	JJ	_	4	amod	_	_
4	proliferation	proliferation	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	MO7e	mo7e	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	.	.	.	.	_	2	punct	_	_

1	Present	present	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	trancriptional	trancriptional	JJ	JJ	_	5	amod	_	_
5	roles	role	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	STAT5	stat5	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	roles	role	NNS	NNS	_	5	conj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	ERK	erk	NN	NN	_	10	nmod	_	_
13	and/or	and/or	CC	CC	_	12	cc	_	_
14	p38	p38	NN	NN	_	12	conj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	normal	normal	JJ	JJ	_	18	amod	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
19	stimulated	stimulate	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	23	case	_	_
21	physiological	physiological	JJ	JJ	_	23	amod	_	_
22	receptor-mediated	receptor-mediated	JJ	JJ	_	23	amod	_	_
23	agonists	agonist	NNS	NNS	_	19	nmod	_	_
24	GM-CSF	gm-csf	NN	NN	_	23	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	FMLP	fmlp	NN	NN	_	24	conj	_	_
27	.	.	.	.	_	3	punct	_	_

1	Possible	possible	JJ	JJ	_	2	amod	_	_
2	roles	role	NNS	NNS	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ERK	erk	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	6	case	_	_
6	proliferation	proliferation	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	transformed	transform	VBN	VBN	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	were	be	VBD	VBD	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	suggested	suggest	VBN	VBN	_	0	root	_	_
13	.	.	.	.	_	12	punct	_	_

1	Tyrphostin	tyrphostin	NN	NN	_	2	compound	_	_
2	AG-490	ag-490	NN	NN	_	3	nsubj	_	_
3	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
4	cytokine-mediated	cytokine-mediated	JJ	JJ	_	7	amod	_	_
5	JAK3/STAT5a/b	jak3/stat5a/b	NN	NN	_	7	compound	_	_
6	signal	signal	NN	NN	_	7	compound	_	_
7	transduction	transduction	NN	NN	_	3	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	cellular	cellular	JJ	JJ	_	10	amod	_	_
10	proliferation	proliferation	NN	NN	_	7	conj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	antigen-activated	antigen-activated	JJ	JJ	_	15	amod	_	_
13	human	human	JJ	JJ	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Janus	janus	NN	NN	_	2	compound	_	_
2	kinase	kinase	NN	NN	_	11	nsubj	_	_
3	3	3	CD	CD	_	2	nummod	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	JAK3	jak3	NN	NN	_	2	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	11	cop	_	_
8	a	a	DT	DT	_	11	det	_	_
9	cytoplasmic	cytoplasmic	JJ	JJ	_	11	amod	_	_
10	tyrosine	tyrosine	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	0	root	_	_
12	required	require	VBN	VBN	_	11	dep	_	_
13	for	for	IN	IN	_	16	case	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	development	development	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	activated	activate	VBN	VBN	_	12	conj	_	_
19	by	by	IN	IN	_	20	case	_	_
20	cytokines	cytokine	NNS	NNS	_	18	nmod	_	_
21	that	that	WDT	WDT	_	22	nsubj	_	_
22	utilize	utilize	VBP	VBP	_	20	acl:relcl	_	_
23	the	the	DT	DT	_	28	det	_	_
24	interleukin-2	interleukin-2	NN	NN	_	28	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	IL-2	il-2	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	receptor	receptor	NN	NN	_	22	dobj	_	_
29	common	common	JJ	JJ	_	28	amod	_	_
30	gamma	gamma	NN	NN	_	31	compound	_	_
31	chain	chain	NN	NN	_	28	dep	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	gamma(c)	gamma(c)	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	.	.	.	.	_	11	punct	_	_

1	Genetic	genetic	JJ	JJ	_	2	amod	_	_
2	inactivation	inactivation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	JAK3	jak3	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	manifested	manifest	VBN	VBN	_	0	root	_	_
7	as	as	IN	IN	_	11	case	_	_
8	severe	severe	JJ	JJ	_	11	amod	_	_
9	combined	combined	JJ	JJ	_	11	amod	_	_
10	immunodeficiency	immunodeficiency	NN	NN	_	11	compound	_	_
11	disease	disease	NN	NN	_	6	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	SCID	scid	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	in	in	IN	IN	_	16	case	_	_
16	humans	human	NNS	NNS	_	11	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	mice	mouse	NNS	NNS	_	16	conj	_	_
19	.	.	.	.	_	6	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	suggested	suggest	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	JAK3	jak3	NN	NN	_	7	nsubj	_	_
7	represents	represent	VBZ	VBZ	_	4	ccomp	_	_
8	a	a	DT	DT	_	10	det	_	_
9	pharmacological	pharmacological	JJ	JJ	_	10	amod	_	_
10	target	target	NN	NN	_	7	dobj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	control	control	VB	VB	_	10	acl	_	_
13	certain	certain	JJ	JJ	_	15	amod	_	_
14	lymphoid-derived	lymphoid-derived	JJ	JJ	_	15	amod	_	_
15	diseases	disease	NNS	NNS	_	12	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	novel	novel	JJ	JJ	_	5	amod	_	_
5	evidence	evidence	NN	NN	_	3	dobj	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	AG-490	ag-490	NN	NN	_	9	nsubj	_	_
8	potently	potently	RB	RB	_	9	advmod	_	_
9	inhibits	inhibit	VBZ	VBZ	_	5	dep	_	_
10	the	the	DT	DT	_	12	det	_	_
11	autokinase	autokinase	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	JAK3	jak3	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	tyrosine	tyrosine	NN	NN	_	17	compound	_	_
17	phosphorylation	phosphorylation	NN	NN	_	12	conj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	DNA	dna	NN	NN	_	20	compound	_	_
20	binding	binding	NN	NN	_	17	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	signal	signal	NN	NN	_	23	compound	_	_
23	transducer	transducer	NN	NN	_	17	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	activator	activator	NN	NN	_	28	compound	_	_
26	of	of	IN	IN	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	5a	5a	NN	NN	_	23	conj	_	_
29	and	and	CC	CC	_	23	cc	_	_
30	5b	5b	NN	NN	_	23	conj	_	_
31	(	(	-LRB-	-LRB-	_	32	punct	_	_
32	STAT5a/b	stat5a/b	NN	NN	_	23	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	.	.	.	.	_	3	punct	_	_

1	Similar	similar	JJ	JJ	_	3	amod	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	other	other	JJ	JJ	_	8	amod	_	_
8	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	use	use	VBP	VBP	_	8	acl:relcl	_	_
11	gamma(c)	gamma(c)	NN	NN	_	10	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	AG-490	ag-490	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	IL-2-mediated	il-2-mediated	JJ	JJ	_	6	amod	_	_
5	proliferative	proliferative	JJ	JJ	_	6	amod	_	_
6	growth	growth	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	with	with	IN	IN	_	16	case	_	_
12	an	a	DT	DT	_	16	det	_	_
13	IC50)	ic50)	NN	NN	_	16	compound	_	_
14	=	=	JJ	JJ	_	16	amod	_	_
15	25	25	CD	CD	_	16	nummod	_	_
16	microM	microm	NN	NN	_	3	nmod	_	_
17	that	that	WDT	WDT	_	20	nsubj	_	_
18	was	be	VBD	VBD	_	20	cop	_	_
19	partially	partially	RB	RB	_	20	advmod	_	_
20	recoverable	recoverable	JJ	JJ	_	16	acl:relcl	_	_
21	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	8	mark	_	_
6	this	this	DT	DT	_	7	det	_	_
7	inhibitor	inhibitor	NN	NN	_	8	nsubj	_	_
8	prevented	prevent	VBD	VBD	_	4	ccomp	_	_
9	tetanus	tetanus	NN	NN	_	13	compound	_	_
10	toxoid	toxoid	NN	NN	_	13	compound	_	_
11	antigen-specific	antigen-specific	JJ	JJ	_	13	amod	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cell	cell	NN	NN	_	8	dobj	_	_
14	proliferation	proliferation	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	expansion	expansion	NN	NN	_	14	conj	_	_
17	but	but	CC	CC	_	8	cc	_	_
18	failed	fail	VBD	VBD	_	8	conj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	block	block	VB	VB	_	18	xcomp	_	_
21	activation	activation	NN	NN	_	20	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Zap70	zap70	NN	NN	_	21	nmod	_	_
24	or	or	CC	CC	_	23	cc	_	_
25	p56Lck	p56lck	NN	NN	_	23	conj	_	_
26	after	after	IN	IN	_	28	case	_	_
27	anti-CD3	anti-cd3	JJ	JJ	_	28	amod	_	_
28	stimulation	stimulation	NN	NN	_	20	nmod	_	_
29	of	of	IN	IN	_	32	case	_	_
30	human	human	JJ	JJ	_	32	amod	_	_
31	T	t	NN	NN	_	32	compound	_	_
32	cells	cell	NNS	NNS	_	28	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	AG-490	ag-490	NN	NN	_	9	nsubj	_	_
9	inhibits	inhibit	VBZ	VBZ	_	6	ccomp	_	_
10	the	the	DT	DT	_	15	det	_	_
11	JAK3-mediated	jak3-mediated	JJ	JJ	_	15	amod	_	_
12	Type	type	NN	NN	_	15	compound	_	_
13	II	ii	CD	CD	_	15	nummod	_	_
14	signaling	signaling	NN	NN	_	15	compound	_	_
15	pathway	pathway	NN	NN	_	9	dobj	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	not	not	RB	RB	_	24	neg	_	_
18	the	the	DT	DT	_	24	det	_	_
19	T	t	NN	NN	_	24	compound	_	_
20	cell	cell	NN	NN	_	24	compound	_	_
21	receptor-derived	receptor-derived	JJ	JJ	_	24	amod	_	_
22	Type	type	NN	NN	_	24	compound	_	_
23	I	i	CD	CD	_	24	nummod	_	_
24	pathway	pathway	NN	NN	_	15	conj	_	_
25	and	and	CC	CC	_	9	cc	_	_
26	possesses	possess	VBZ	VBZ	_	9	conj	_	_
27	therapeutic	therapeutic	JJ	JJ	_	28	amod	_	_
28	potential	potential	NN	NN	_	26	dobj	_	_
29	for	for	IN	IN	_	32	case	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell-derived	cell-derived	JJ	JJ	_	32	amod	_	_
32	pathologies	pathology	NNS	NNS	_	28	nmod	_	_
33	such	such	JJ	JJ	_	36	case	_	_
34	as	as	IN	IN	_	33	mwe	_	_
35	graft-versus-host	graft-versus-host	JJ	JJ	_	36	amod	_	_
36	disease	disease	NN	NN	_	32	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	allergy	allergy	NN	NN	_	36	conj	_	_
39	,	,	,	,	_	36	punct	_	_
40	and	and	CC	CC	_	36	cc	_	_
41	autoimmune	autoimmune	JJ	JJ	_	42	amod	_	_
42	disorders	disorder	NNS	NNS	_	36	conj	_	_
43	.	.	.	.	_	6	punct	_	_

1	Genetic	genetic	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	0	root	_	_
3	for	for	IN	IN	_	6	case	_	_
4	an	a	DT	DT	_	6	det	_	_
5	additional	additional	JJ	JJ	_	6	amod	_	_
6	factor	factor	NN	NN	_	2	nmod	_	_
7	required	require	VBN	VBN	_	6	acl	_	_
8	for	for	IN	IN	_	11	case	_	_
9	erythropoietin-induced	erythropoietin-induced	JJ	JJ	_	11	amod	_	_
10	signal	signal	NN	NN	_	11	compound	_	_
11	transduction	transduction	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Erythropoietin	erythropoietin	NN	NN	_	12	nsubjpass	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	EPO	epo	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	and	and	CC	CC	_	1	cc	_	_
6	its	its	PRP$	PRP$	_	7	nmod:poss	_	_
7	receptor	receptor	NN	NN	_	1	conj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	EPOR	epor	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	are	be	VBP	VBP	_	12	auxpass	_	_
12	required	require	VBN	VBN	_	0	root	_	_
13	for	for	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	development	development	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	mature	mature	JJ	JJ	_	18	amod	_	_
18	erythrocytes	erythrocyte	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	After	after	IN	IN	_	2	case	_	_
2	binding	binding	NN	NN	_	8	nmod	_	_
3	of	of	IN	IN	_	4	case	_	_
4	ligand	ligand	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	EPOR	epor	NN	NN	_	8	nsubj	_	_
8	activates	activate	VBZ	VBZ	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	variety	variety	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	signaling	signaling	NN	NN	_	13	compound	_	_
13	pathways	pathway	NNS	NNS	_	10	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	ultimately	ultimately	RB	RB	_	16	advmod	_	_
16	control	control	VBP	VBP	_	13	acl:relcl	_	_
17	cellular	cellular	JJ	JJ	_	18	amod	_	_
18	proliferation	proliferation	NN	NN	_	16	dobj	_	_
19	,	,	,	,	_	18	punct	_	_
20	survival	survival	NN	NN	_	18	appos	_	_
21	,	,	,	,	_	20	punct	_	_
22	and	and	CC	CC	_	20	cc	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	8	punct	_	_

1	Although	although	IN	IN	_	4	mark	_	_
2	erythroid	erythroid	JJ	JJ	_	3	amod	_	_
3	progenitors	progenitor	NNS	NNS	_	4	nsubj	_	_
4	appear	appear	VBP	VBP	_	32	advcl	_	_
5	to	to	TO	TO	_	11	mark	_	_
6	be	be	VB	VB	_	11	cop	_	_
7	the	the	DT	DT	_	11	det	_	_
8	principal	principal	JJ	JJ	_	11	amod	_	_
9	EPO-responsive	epo-responsive	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	type	type	NN	NN	_	4	xcomp	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vivo	vivo	FW	FW	_	11	advmod	_	_
14	due	due	JJ	JJ	_	18	case	_	_
15	to	to	TO	TO	_	14	mwe	_	_
16	the	the	DT	DT	_	18	det	_	_
17	restricted	restricted	JJ	JJ	_	18	amod	_	_
18	expression	expression	NN	NN	_	11	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	EPOR	epor	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	32	punct	_	_
23	many	many	JJ	JJ	_	27	amod	_	_
24	growth	growth	NN	NN	_	27	compound	_	_
25	factor-dependent	factor-dependent	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lines	line	NNS	NNS	_	32	nsubj	_	_
28	expressing	express	VBG	VBG	_	27	acl	_	_
29	the	the	DT	DT	_	30	det	_	_
30	EPOR	epor	NN	NN	_	28	dobj	_	_
31	can	can	MD	MD	_	32	aux	_	_
32	respond	respond	VB	VB	_	0	root	_	_
33	to	to	TO	TO	_	34	case	_	_
34	EPO	epo	NN	NN	_	32	nmod	_	_
35	by	by	IN	IN	_	36	mark	_	_
36	activating	activate	VBG	VBG	_	32	advcl	_	_
37	many	many	JJ	JJ	_	36	dobj	_	_
38	or	or	CC	CC	_	37	cc	_	_
39	all	all	DT	DT	_	37	conj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	these	these	DT	DT	_	42	det	_	_
42	pathways	pathway	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	32	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	we	we	PRP	PRP	_	8	nsubj	_	_
7	have	have	VBP	VBP	_	8	aux	_	_
8	identified	identify	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	cellular	cellular	JJ	JJ	_	11	amod	_	_
11	context	context	NN	NN	_	8	dobj	_	_
12	(	(	-LRB-	-LRB-	_	20	punct	_	_
13	the	the	DT	DT	_	20	det	_	_
14	interleukin-2	interleukin-2	NN	NN	_	20	compound	_	_
15	-LSB-	-lsb-	-LRB-	-LRB-	_	16	punct	_	_
16	IL-2	il-2	NN	NN	_	14	appos	_	_
17	-RSB-	-rsb-	-RRB-	-RRB-	_	16	punct	_	_
18	-dependent	-dependent	JJ	JJ	_	20	amod	_	_
19	HT-2	ht-2	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	11	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	in	in	IN	IN	_	23	case	_	_
23	which	which	WDT	WDT	_	30	nmod	_	_
24	the	the	DT	DT	_	26	det	_	_
25	EPO	epo	NN	NN	_	26	compound	_	_
26	stimulation	stimulation	NN	NN	_	30	nsubj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	EPOR	epor	NN	NN	_	26	nmod	_	_
30	fails	fail	VBZ	VBZ	_	11	acl:relcl	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	support	support	VB	VB	_	30	xcomp	_	_
33	cellular	cellular	JJ	JJ	_	34	amod	_	_
34	proliferation	proliferation	NN	NN	_	32	dobj	_	_
35	,	,	,	,	_	34	punct	_	_
36	STAT-5	stat-5	NN	NN	_	37	compound	_	_
37	induction	induction	NN	NN	_	34	conj	_	_
38	,	,	,	,	_	34	punct	_	_
39	or	or	CC	CC	_	34	cc	_	_
40	MAPK	mapk	NN	NN	_	41	compound	_	_
41	activation	activation	NN	NN	_	34	conj	_	_
42	,	,	,	,	_	32	punct	_	_
43	despite	despite	IN	IN	_	45	case	_	_
44	efficient	efficient	JJ	JJ	_	45	amod	_	_
45	phosphorylation	phosphorylation	NN	NN	_	32	nmod	_	_
46	of	of	IN	IN	_	48	case	_	_
47	the	the	DT	DT	_	48	dep	_	_
48	EPOR	epor	NN	NN	_	45	nmod	_	_
49	and	and	CC	CC	_	48	cc	_	_
50	JAK2	jak2	NN	NN	_	48	conj	_	_
51	and	and	CC	CC	_	45	cc	_	_
52	inhibition	inhibition	NN	NN	_	45	conj	_	_
53	of	of	IN	IN	_	54	case	_	_
54	apoptosis	apoptosis	NN	NN	_	52	nmod	_	_
55	after	after	IN	IN	_	56	case	_	_
56	withdrawal	withdrawal	NN	NN	_	54	nmod	_	_
57	of	of	IN	IN	_	58	case	_	_
58	IL-2	il-2	NN	NN	_	56	nmod	_	_
59	.	.	.	.	_	8	punct	_	_

1	Interestingly	interestingly	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	when	when	WRB	WRB	_	5	advmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	fused	fuse	VBD	VBD	_	22	advcl	_	_
6	HT-2	ht-2	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	5	dobj	_	_
8	expressing	express	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	EPOR	epor	NN	NN	_	8	dobj	_	_
11	with	with	IN	IN	_	13	case	_	_
12	Ba/F3	ba/f3	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	complementation	complementation	NN	NN	_	17	compound	_	_
17	assay	assay	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	the	the	DT	DT	_	21	det	_	_
20	resulting	result	VBG	VBG	_	21	amod	_	_
21	hybridomas	hybridomas	NN	NN	_	22	nsubj	_	_
22	proliferated	proliferate	VBD	VBD	_	0	root	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	potently	potently	RB	RB	_	25	advmod	_	_
25	activated	activate	VBD	VBD	_	22	conj	_	_
26	STAT-5	stat-5	NN	NN	_	22	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	MAPK	mapk	NN	NN	_	26	conj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	response	response	NN	NN	_	22	nmod	_	_
31	to	to	TO	TO	_	32	case	_	_
32	EPO	epo	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	22	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	an	a	DT	DT	_	8	det	_	_
6	unidentified	unidentified	JJ	JJ	_	8	amod	_	_
7	cellular	cellular	JJ	JJ	_	8	amod	_	_
8	factor	factor	NN	NN	_	10	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	needed	need	VBN	VBN	_	3	ccomp	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	mediate	mediate	VB	VB	_	10	xcomp	_	_
13	signaling	signaling	NN	NN	_	12	dobj	_	_
14	by	by	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	EPOR	epor	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	Ba/F3	ba/f3	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	6	nsubj	_	_
5	apparently	apparently	RB	RB	_	6	advmod	_	_
6	express	express	VBP	VBP	_	0	root	_	_
7	this	this	DT	DT	_	8	det	_	_
8	factor	factor	NN	NN	_	19	nsubj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	s	s	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	somatic	somatic	JJ	JJ	_	14	amod	_	_
14	fusions	fusion	NNS	NNS	_	8	conj	_	_
15	can	can	MD	MD	_	19	aux	_	_
16	,	,	,	,	_	19	punct	_	_
17	therefore	therefore	RB	RB	_	19	advmod	_	_
18	,	,	,	,	_	19	punct	_	_
19	confer	confer	VB	VB	_	6	ccomp	_	_
20	EPO-responsiveness	epo-responsiveness	NN	NN	_	19	dobj	_	_
21	to	to	TO	TO	_	23	case	_	_
22	HT-2	ht-2	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	that	that	WDT	WDT	_	25	nsubj	_	_
25	lack	lack	VBP	VBP	_	23	acl:relcl	_	_
26	this	this	DT	DT	_	27	det	_	_
27	factor	factor	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	6	punct	_	_

1	GATA-1	gata-1	NN	NN	_	4	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	erythropoietin	erythropoietin	NN	NN	_	1	conj	_	_
4	cooperate	cooperate	VBP	VBP	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	promote	promote	VB	VB	_	4	xcomp	_	_
7	erythroid	erythroid	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	survival	survival	NN	NN	_	6	dobj	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	regulating	regulate	VBG	VBG	_	6	advcl	_	_
12	bcl-xL	bcl-xl	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	6	nsubj	_	_
4	GATA-1	gata-1	NN	NN	_	3	dep	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	essential	essential	JJ	JJ	_	0	root	_	_
7	for	for	IN	IN	_	9	case	_	_
8	normal	normal	JJ	JJ	_	9	amod	_	_
9	erythropoiesis	erythropoiesis	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	examining	examine	VBG	VBG	_	10	advcl	_	_
3	in	in	IN	IN	_	7	case	_	_
4	vitro-differentiated	vitro-differentiated	JJ	JJ	_	7	case	_	_
5	embryonic	embryonic	JJ	JJ	_	7	case	_	_
6	stem	stem	NN	NN	_	7	dep	_	_
7	cells	cell	NNS	NNS	_	2	advcl	_	_
8	,	,	,	,	_	10	punct	_	_
9	we	we	PRP	PRP	_	10	nsubj	_	_
10	showed	show	VBD	VBD	_	0	root	_	_
11	previously	previously	RB	RB	_	10	advmod	_	_
12	that	that	IN	IN	_	22	mark	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	absence	absence	NN	NN	_	22	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	GATA-1	gata-1	NN	NN	_	15	nmod	_	_
18	,	,	,	,	_	22	punct	_	_
19	committed	commit	VBN	VBN	_	21	amod	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	precursors	precursor	NNS	NNS	_	22	nsubj	_	_
22	fail	fail	VBP	VBP	_	10	ccomp	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	complete	complete	VB	VB	_	22	xcomp	_	_
25	maturation	maturation	NN	NN	_	24	dobj	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	instead	instead	RB	RB	_	28	advmod	_	_
28	undergo	undergo	VBP	VBP	_	24	conj	_	_
29	apoptosis	apoptosis	NN	NN	_	28	dobj	_	_
30	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanisms	mechanism	NNS	NNS	_	10	nsubj	_	_
3	by	by	IN	IN	_	4	case	_	_
4	which	which	WDT	WDT	_	6	nmod	_	_
5	GATA-1	gata-1	NN	NN	_	6	nsubj	_	_
6	controls	control	VBZ	VBZ	_	2	acl:relcl	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	survival	survival	NN	NN	_	6	dobj	_	_
9	are	be	VBP	VBP	_	10	aux	_	_
10	unknown	unknown	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	in	in	IN	IN	_	7	case	_	_
6	erythroid	erythroid	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	11	nmod	_	_
8	,	,	,	,	_	11	punct	_	_
9	GATA-1	gata-1	NN	NN	_	11	nsubj	_	_
10	strongly	strongly	RB	RB	_	11	advmod	_	_
11	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
12	the	the	DT	DT	_	13	det	_	_
13	expression	expression	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	anti-apoptotic	anti-apoptotic	JJ	JJ	_	17	amod	_	_
17	protein	protein	NN	NN	_	13	nmod	_	_
18	bcl-xL	bcl-xl	NN	NN	_	17	dep	_	_
19	,	,	,	,	_	17	punct	_	_
20	but	but	CC	CC	_	17	cc	_	_
21	not	not	RB	RB	_	24	neg	_	_
22	the	the	DT	DT	_	24	det	_	_
23	related	related	JJ	JJ	_	24	amod	_	_
24	proteins	protein	NNS	NNS	_	17	conj	_	_
25	bcl-2	bcl-2	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	mcl-1	mcl-1	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	3	punct	_	_

1	Consistent	consistent	JJ	JJ	_	20	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	bcl-xL	bcl-xl	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	mediating	mediate	VBG	VBG	_	1	advcl	_	_
9	GATA-1-induced	gata-1-induced	JJ	JJ	_	12	amod	_	_
10	erythroid	erythroid	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	survival	survival	NN	NN	_	8	dobj	_	_
13	,	,	,	,	_	20	punct	_	_
14	in	in	FW	FW	_	19	compound	_	_
15	vitro-differentiated	vitro-differentiated	JJ	JJ	_	19	amod	_	_
16	bcl-xL-/-	bcl-xl-/-	JJ	JJ	_	19	amod	_	_
17	embryonic	embryonic	JJ	JJ	_	19	amod	_	_
18	stem	stem	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	20	nsubj	_	_
20	fail	fail	VBP	VBP	_	0	root	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	generate	generate	VB	VB	_	20	xcomp	_	_
23	viable	viable	JJ	JJ	_	27	amod	_	_
24	mature	mature	JJ	JJ	_	27	amod	_	_
25	definitive	definitive	JJ	JJ	_	27	amod	_	_
26	erythroid	erythroid	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	22	dobj	_	_
28	,	,	,	,	_	27	punct	_	_
29	a	a	DT	DT	_	30	det	_	_
30	phenotype	phenotype	NN	NN	_	27	appos	_	_
31	resembling	resemble	VBG	VBG	_	30	acl	_	_
32	that	that	DT	DT	_	31	xcomp	_	_
33	of	of	IN	IN	_	36	case	_	_
34	GATA-1	gata-1	NN	NN	_	36	compound	_	_
35	gene	gene	NN	NN	_	36	compound	_	_
36	disruption	disruption	NN	NN	_	32	nmod	_	_
37	.	.	.	.	_	20	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	18	mark	_	_
7	erythropoietin	erythropoietin	NN	NN	_	18	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	12	nsubjpass	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	required	require	VBN	VBN	_	7	acl:relcl	_	_
13	for	for	IN	IN	_	16	case	_	_
14	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	survival	survival	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	18	punct	_	_
18	cooperates	cooperate	VBZ	VBZ	_	5	ccomp	_	_
19	with	with	IN	IN	_	20	case	_	_
20	GATA-1	gata-1	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	stimulate	stimulate	VB	VB	_	18	ccomp	_	_
23	bcl-xL	bcl-xl	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	maintain	maintain	VB	VB	_	22	conj	_	_
29	erythroid	erythroid	JJ	JJ	_	31	amod	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	viability	viability	NN	NN	_	28	dobj	_	_
32	during	during	IN	IN	_	34	case	_	_
33	terminal	terminal	JJ	JJ	_	34	amod	_	_
34	maturation	maturation	NN	NN	_	22	nmod	_	_
35	.	.	.	.	_	5	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	9	mark	_	_
7	bcl-xL	bcl-xl	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	essential	essential	JJ	JJ	_	5	ccomp	_	_
10	for	for	IN	IN	_	13	case	_	_
11	normal	normal	JJ	JJ	_	13	amod	_	_
12	erythroid	erythroid	JJ	JJ	_	13	amod	_	_
13	development	development	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	suggest	suggest	VBP	VBP	_	5	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	regulatory	regulatory	JJ	JJ	_	18	amod	_	_
18	hierarchy	hierarchy	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	26	nmod	_	_
21	bcl-xL	bcl-xl	NN	NN	_	26	nsubj	_	_
22	is	be	VBZ	VBZ	_	26	cop	_	_
23	a	a	DT	DT	_	26	det	_	_
24	critical	critical	JJ	JJ	_	26	amod	_	_
25	downstream	downstream	JJ	JJ	_	26	amod	_	_
26	effector	effector	NN	NN	_	18	acl:relcl	_	_
27	of	of	IN	IN	_	28	case	_	_
28	GATA-1	gata-1	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	erythropoietin-mediated	erythropoietin-mediated	JJ	JJ	_	31	amod	_	_
31	signals	signal	NNS	NNS	_	28	conj	_	_
32	.	.	.	.	_	5	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	2	nsubj	_	_
2	functions	function	VBZ	VBZ	_	0	root	_	_
3	as	as	IN	IN	_	10	case	_	_
4	both	both	CC	CC	_	10	dep	_	_
5	a	a	DT	DT	_	10	det	_	_
6	proapoptotic	proapoptotic	JJ	JJ	_	10	amod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	antiapoptotic	antiapoptotic	JJ	JJ	_	6	conj	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	factor	factor	NN	NN	_	2	nmod	_	_
11	within	within	IN	IN	_	15	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	single	single	JJ	JJ	_	15	amod	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	type	type	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Recently	recently	RB	RB	_	5	advmod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	5	nsubjpass	_	_
3	has	have	VBZ	VBZ	_	5	aux	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	have	have	VB	VB	_	5	xcomp	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	proapoptotic	proapoptotic	JJ	JJ	_	12	amod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	antiapoptotic	antiapoptotic	JJ	JJ	_	9	conj	_	_
12	functions	function	NNS	NNS	_	7	dobj	_	_
13	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	hybridomas	hybridoma	NNS	NNS	_	12	nmod	_	_
5	,	,	,	,	_	12	punct	_	_
6	both	both	CC	CC	_	9	cc:preconj	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activators	activator	NNS	NNS	_	12	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	glucocorticoids	glucocorticoid	NNS	NNS	_	9	conj	_	_
12	induce	induce	VBP	VBP	_	0	root	_	_
13	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
14	.	.	.	.	_	12	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	blockade	blockade	NN	NN	_	16	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	5	nmod	_	_
9	,	,	,	,	_	5	punct	_	_
10	using	use	VBG	VBG	_	5	dep	_	_
11	a	a	DT	DT	_	14	det	_	_
12	dominant	dominant	JJ	JJ	_	14	amod	_	_
13	negative	negative	JJ	JJ	_	14	amod	_	_
14	IkappaBalpha	ikappabalpha	NN	NN	_	10	dobj	_	_
15	,	,	,	,	_	16	punct	_	_
16	has	have	VBZ	VBZ	_	3	ccomp	_	_
17	opposite	opposite	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	16	dobj	_	_
19	on	on	IN	IN	_	23	case	_	_
20	these	these	DT	DT	_	23	det	_	_
21	two	two	CD	CD	_	23	nummod	_	_
22	apoptotic	apoptotic	JJ	JJ	_	23	amod	_	_
23	signals	signal	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

1	Treatment	treatment	NN	NN	_	9	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	PMA	pma	NN	NN	_	1	nmod	_	_
4	plus	plus	CC	CC	_	3	cc	_	_
5	ionomycin	ionomycin	NN	NN	_	3	conj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	P/I	p/i	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	results	result	VBZ	VBZ	_	0	root	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	upregulation	upregulation	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Fas	fas	NN	NN	_	15	compound	_	_
15	Ligand	ligand	NN	NN	_	12	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	FasL	fasl	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	induction	induction	NN	NN	_	12	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	apoptosis	apoptosis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Inhibition	inhibition	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	1	nmod	_	_
5	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	P/I	p/i	NN	NN	_	8	nmod:npmod	_	_
8	mediated	mediated	JJ	JJ	_	9	amod	_	_
9	induction	induction	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	FasL	fasl	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	decreases	decrease	VBZ	VBZ	_	5	conj	_	_
15	the	the	DT	DT	_	16	det	_	_
16	level	level	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	cultures	culture	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	5	punct	_	_
23	thus	thus	RB	RB	_	24	advmod	_	_
24	establishing	establish	VBG	VBG	_	5	advcl	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	24	dobj	_	_
26	as	as	IN	IN	_	29	case	_	_
27	a	a	DT	DT	_	29	det	_	_
28	proapoptotic	proapoptotic	JJ	JJ	_	29	amod	_	_
29	factor	factor	NN	NN	_	24	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	this	this	DT	DT	_	32	det	_	_
32	context	context	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	5	punct	_	_

1	Conversely	conversely	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	inhibition	inhibition	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	3	nmod	_	_
6	confers	confer	VBZ	VBZ	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	tenfold	tenfold	JJ	JJ	_	9	amod	_	_
9	increase	increase	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	glucocorticoid	glucocorticoid	NN	NN	_	13	compound	_	_
12	mediated	mediated	JJ	JJ	_	13	amod	_	_
13	apoptosis	apoptosis	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	6	punct	_	_
15	establishing	establish	VBG	VBG	_	6	advcl	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	19	nsubj	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	functions	function	VBZ	VBZ	_	15	ccomp	_	_
20	as	as	IN	IN	_	23	case	_	_
21	an	a	DT	DT	_	23	det	_	_
22	antiapoptotic	antiapoptotic	JJ	JJ	_	23	amod	_	_
23	factor	factor	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	9	nsubj	_	_
5	is	be	VBZ	VBZ	_	9	cop	_	_
6	a	a	DT	DT	_	9	det	_	_
7	context-dependent	context-dependent	JJ	JJ	_	9	amod	_	_
8	apoptosis	apoptosis	NN	NN	_	9	compound	_	_
9	regulator	regulator	NN	NN	_	2	ccomp	_	_
10	.	.	.	.	_	2	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	data	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	7	nsubj	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	function	function	VB	VB	_	3	ccomp	_	_
8	as	as	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	antiapoptotic	antiapoptotic	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	thymocytes	thymocyte	NNS	NNS	_	11	nmod	_	_
14	while	while	IN	IN	_	15	mark	_	_
15	functioning	function	VBG	VBG	_	7	advcl	_	_
16	as	as	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	proapoptotic	proapoptotic	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	24	case	_	_
21	mature	mature	JJ	JJ	_	24	amod	_	_
22	peripheral	peripheral	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	3-deazaadenosine	3-deazaadenosine	NN	NN	_	8	nsubj	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	6	det	_	_
4	S-adenosylhomocysteine	s-adenosylhomocysteine	NN	NN	_	6	compound	_	_
5	hydrolase	hydrolase	NN	NN	_	6	compound	_	_
6	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
7	,	,	,	,	_	8	punct	_	_
8	has	have	VBZ	VBZ	_	0	root	_	_
9	dual	dual	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	on	on	IN	IN	_	13	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	Inhibition	inhibition	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	promotion	promotion	NN	NN	_	1	conj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	IkappaBalpha	ikappabalpha	NN	NN	_	10	compound	_	_
10	degradation	degradation	NN	NN	_	7	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Previously	previously	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	reported	report	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	18	mark	_	_
5	3-deazaadenosine	3-deazaadenosine	NN	NN	_	18	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	DZA	dza	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	a	a	DT	DT	_	12	dep	_	_
11	potent	potent	JJ	JJ	_	12	amod	_	_
12	inhibitor	inhibitor	NN	NN	_	5	appos	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	substrate	substrate	NN	NN	_	12	conj	_	_
15	for	for	IN	IN	_	17	case	_	_
16	S-adenosylhomocysteine	s-adenosylhomocysteine	NN	NN	_	17	compound	_	_
17	hydrolase	hydrolase	NN	NN	_	12	nmod	_	_
18	inhibits	inhibit	VBZ	VBZ	_	3	ccomp	_	_
19	bacterial	bacterial	JJ	JJ	_	21	amod	_	_
20	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	21	amod	_	_
21	transcription	transcription	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	tumor	tumor	NN	NN	_	25	compound	_	_
24	necrosis	necrosis	NN	NN	_	25	compound	_	_
25	factor-alpha	factor-alpha	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	interleukin-1beta	interleukin-1beta	NN	NN	_	25	conj	_	_
28	in	in	IN	IN	_	33	case	_	_
29	mouse	mouse	NN	NN	_	33	compound	_	_
30	macrophage	macrophage	NN	NN	_	33	compound	_	_
31	RAW	raw	NN	NN	_	33	compound	_	_
32	264.7	264.7	CD	CD	_	33	nummod	_	_
33	cells	cell	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effects	effect	NNS	NNS	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	DZA	dza	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	17	case	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	factor-kappaB	factor-kappab	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	regulation	regulation	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	DZA	dza	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	transcriptional	transcriptional	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	through	through	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	hindrance	hindrance	NN	NN	_	2	nmod	_	_
11	of	of	IN	IN	_	16	case	_	_
12	p65	p65	NN	NN	_	16	compound	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	Rel-A	rel-a	NN	NN	_	16	compound	_	_
15	)	)	-RRB-	-RRB-	_	16	punct	_	_
16	phosphorylation	phosphorylation	NN	NN	_	10	nmod	_	_
17	without	without	IN	IN	_	18	case	_	_
18	reduction	reduction	NN	NN	_	2	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	nuclear	nuclear	JJ	JJ	_	22	amod	_	_
22	translocation	translocation	NN	NN	_	18	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	DNA	dna	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	22	conj	_	_
27	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	effect	effect	NN	NN	_	11	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	DZA	dza	NN	NN	_	3	nmod	_	_
6	on	on	IN	IN	_	9	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
8	transcriptional	transcriptional	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	potentiated	potentiate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	addition	addition	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	homocysteine	homocysteine	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	Taken	take	VBN	VBN	_	5	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	DZA	dza	NN	NN	_	5	nsubj	_	_
5	promotes	promote	VBZ	VBZ	_	0	root	_	_
6	the	the	DT	DT	_	8	det	_	_
7	proteolytic	proteolytic	JJ	JJ	_	8	amod	_	_
8	degradation	degradation	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	IkappaBalpha	ikappabalpha	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	but	but	CC	CC	_	10	cc	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	IkappaBbeta	ikappabbeta	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	5	punct	_	_
16	resulting	result	VBG	VBG	_	5	advcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	an	a	DT	DT	_	19	det	_	_
19	increase	increase	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	DNA	dna	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	19	nmod	_	_
24	of	of	IN	IN	_	25	case	_	_
25	NF-kappaB	nf-kappab	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	nucleus	nucleus	NN	NN	_	25	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	the	the	DT	DT	_	31	det	_	_
31	absence	absence	NN	NN	_	16	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	its	its	PRP$	PRP$	_	35	nmod:poss	_	_
34	transcriptional	transcriptional	JJ	JJ	_	35	amod	_	_
35	activity	activity	NN	NN	_	31	acl	_	_
36	in	in	IN	IN	_	39	case	_	_
37	RAW	raw	NN	NN	_	39	compound	_	_
38	264.7	264.7	CD	CD	_	39	nummod	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	reduction	reduction	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	IkappaBalpha	ikappabalpha	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	6	case	_	_
6	DZA	dza	NN	NN	_	2	nmod	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	neither	neither	CC	CC	_	9	cc:preconj	_	_
9	involved	involve	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	14	case	_	_
11	IkappaB	ikappab	NN	NN	_	14	compound	_	_
12	kinase	kinase	NN	NN	_	14	compound	_	_
13	complex	complex	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	9	nmod	_	_
15	nor	nor	CC	CC	_	9	cc	_	_
16	modulated	modulate	VBN	VBN	_	9	conj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	addition	addition	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	homocysteine	homocysteine	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggests	suggest	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	11	mark	_	_
6	DZA	dza	NN	NN	_	11	nsubj	_	_
7	may	may	MD	MD	_	11	aux	_	_
8	be	be	VB	VB	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	potent	potent	JJ	JJ	_	11	amod	_	_
11	drug	drug	NN	NN	_	4	ccomp	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	treatment	treatment	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	diseases	disease	NNS	NNS	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	which	which	WDT	WDT	_	20	nmod	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	nsubj	_	_
20	plays	play	VBZ	VBZ	_	14	acl:relcl	_	_
21	a	a	DT	DT	_	24	det	_	_
22	central	central	JJ	JJ	_	24	amod	_	_
23	pathogenic	pathogenic	JJ	JJ	_	24	amod	_	_
24	role	role	NN	NN	_	20	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	as	as	RB	RB	_	24	cc	_	_
27	well	well	RB	RB	_	26	mwe	_	_
28	as	as	IN	IN	_	26	mwe	_	_
29	a	a	DT	DT	_	31	det	_	_
30	useful	useful	JJ	JJ	_	31	amod	_	_
31	tool	tool	NN	NN	_	24	conj	_	_
32	for	for	IN	IN	_	33	mark	_	_
33	studying	study	VBG	VBG	_	31	acl	_	_
34	the	the	DT	DT	_	35	dep	_	_
35	regulation	regulation	NN	NN	_	33	dobj	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	physiological	physiological	JJ	JJ	_	38	amod	_	_
38	functions	function	NNS	NNS	_	35	conj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	NF-kappaB	nf-kappab	NN	NN	_	35	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	STAT1	stat1	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	during	during	IN	IN	_	7	case	_	_
4	monocyte	monocyte	NN	NN	_	7	compound	_	_
5	to	to	TO	TO	_	7	dep	_	_
6	macrophage	macrophage	NN	NN	_	7	compound	_	_
7	maturation	maturation	NN	NN	_	2	nmod	_	_
8	:	:	:	:	_	2	punct	_	_
9	role	role	NN	NN	_	2	dep	_	_
10	of	of	IN	IN	_	12	case	_	_
11	adhesion	adhesion	NN	NN	_	12	compound	_	_
12	molecules	molecule	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	monocytes	monocyte	NNS	NNS	_	10	nsubj	_	_
3	isolated	isolate	VBN	VBN	_	2	acl	_	_
4	from	from	IN	IN	_	6	case	_	_
5	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
6	blood	blood	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	healthy	healthy	JJ	JJ	_	9	amod	_	_
9	donors	donor	NNS	NNS	_	6	nmod	_	_
10	show	show	VBP	VBP	_	0	root	_	_
11	a	a	DT	DT	_	13	det	_	_
12	time-dependent	time-dependent	JJ	JJ	_	13	amod	_	_
13	differentiation	differentiation	NN	NN	_	10	dobj	_	_
14	into	into	IN	IN	_	15	case	_	_
15	macrophages	macrophage	NNS	NNS	_	13	nmod	_	_
16	upon	upon	IN	IN	_	19	case	_	_
17	in	in	FW	FW	_	19	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	cultivation	cultivation	NN	NN	_	13	nmod	_	_
20	,	,	,	,	_	10	punct	_	_
21	closely	closely	RB	RB	_	22	advmod	_	_
22	mimicking	mimic	VBG	VBG	_	10	advcl	_	_
23	their	they	PRP$	PRP$	_	26	nmod:poss	_	_
24	in	in	FW	FW	_	26	compound	_	_
25	vivo	vivo	FW	FW	_	26	compound	_	_
26	migration	migration	NN	NN	_	22	dobj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	maturation	maturation	NN	NN	_	26	conj	_	_
29	into	into	IN	IN	_	31	case	_	_
30	extravascular	extravascular	JJ	JJ	_	31	amod	_	_
31	tissues	tissue	NNS	NNS	_	22	nmod	_	_
32	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mediator	mediator	NN	NN	_	14	nsubjpass	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	s	s	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	of	of	IN	IN	_	9	case	_	_
7	this	this	DT	DT	_	9	det	_	_
8	maturation	maturation	NN	NN	_	9	compound	_	_
9	process	process	NN	NN	_	2	nmod	_	_
10	has	have	VBZ	VBZ	_	14	aux	_	_
11	not	not	RB	RB	_	14	neg	_	_
12	been	be	VBN	VBN	_	14	auxpass	_	_
13	yet	yet	RB	RB	_	14	advmod	_	_
14	defined	define	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	involvement	involvement	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	15	case	_	_
6	signal	signal	JJ	JJ	_	7	amod	_	_
7	transducers	transducer	NNS	NNS	_	15	compound	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	activators	activator	NNS	NNS	_	11	compound	_	_
10	of	of	IN	IN	_	11	amod	_	_
11	transcription	transcription	NN	NN	_	7	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	STAT	stat	NN	NN	_	7	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	factors	factor	NNS	NNS	_	4	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	this	this	DT	DT	_	18	det	_	_
18	phenomenon	phenomenon	NN	NN	_	4	nmod	_	_
19	and	and	CC	CC	_	2	cc	_	_
20	reported	report	VBD	VBD	_	2	conj	_	_
21	the	the	DT	DT	_	26	det	_	_
22	specific	specific	JJ	JJ	_	26	amod	_	_
23	,	,	,	,	_	22	punct	_	_
24	time-dependent	time-dependent	JJ	JJ	_	22	dep	_	_
25	,	,	,	,	_	26	punct	_	_
26	activation	activation	NN	NN	_	20	dobj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	STAT1	stat1	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	26	nmod	_	_
30	starting	start	VBG	VBG	_	26	dep	_	_
31	at	at	IN	IN	_	32	case	_	_
32	day	day	NN	NN	_	30	nmod	_	_
33	0/1	0/1	CD	CD	_	32	nummod	_	_
34	of	of	IN	IN	_	35	case	_	_
35	cultivation	cultivation	NN	NN	_	32	nmod	_	_
36	and	and	CC	CC	_	30	cc	_	_
37	maximally	maximally	RB	RB	_	38	advmod	_	_
38	expressed	express	VBN	VBN	_	30	conj	_	_
39	at	at	IN	IN	_	40	case	_	_
40	day	day	NN	NN	_	38	nmod	_	_
41	5	5	CD	CD	_	40	nummod	_	_
42	.	.	.	.	_	2	punct	_	_

1	STAT1	stat1	NN	NN	_	2	compound	_	_
2	activity	activity	NN	NN	_	4	nsubj	_	_
3	was	be	VBD	VBD	_	4	cop	_	_
4	evident	evident	JJ	JJ	_	0	root	_	_
5	on	on	IN	IN	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	STAT	stat	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	sequences	sequence	NNS	NNS	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	SBE	sbe	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	present	present	JJ	JJ	_	9	amod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	promoters	promoter	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	genes	gene	NNS	NNS	_	16	nmod	_	_
19	which	which	WDT	WDT	_	21	nsubjpass	_	_
20	are	be	VBP	VBP	_	21	auxpass	_	_
21	up-regulated	up-regulate	VBN	VBN	_	18	acl:relcl	_	_
22	during	during	IN	IN	_	26	case	_	_
23	monocyte	monocyte	NN	NN	_	26	compound	_	_
24	to	to	TO	TO	_	23	dep	_	_
25	macrophage	macrophage	NN	NN	_	23	dep	_	_
26	maturation	maturation	NN	NN	_	21	nmod	_	_
27	such	such	JJ	JJ	_	29	case	_	_
28	as	as	IN	IN	_	27	mwe	_	_
29	FcgammaRI	fcgammari	NN	NN	_	21	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	ICAM-1	icam-1	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	16	punct	_	_
33	and	and	CC	CC	_	16	cc	_	_
34	in	in	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	promoter	promoter	NN	NN	_	16	conj	_	_
37	of	of	IN	IN	_	43	case	_	_
38	the	the	DT	DT	_	43	det	_	_
39	transcription	transcription	NN	NN	_	43	compound	_	_
40	factor	factor	NN	NN	_	43	compound	_	_
41	IFN	ifn	NN	NN	_	43	compound	_	_
42	regulatory	regulatory	JJ	JJ	_	43	amod	_	_
43	factor-1	factor-1	NN	NN	_	36	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	Moreover	moreover	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effect	effect	NN	NN	_	13	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	adhesion	adhesion	NN	NN	_	4	nmod	_	_
8	to	to	TO	TO	_	9	case	_	_
9	fibronectin	fibronectin	NN	NN	_	4	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	laminin	laminin	NN	NN	_	9	conj	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	studied	study	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	investigate	investigate	VB	VB	_	13	xcomp	_	_
16	mechanisms	mechanism	NNS	NNS	_	15	dobj	_	_
17	involved	involve	VBN	VBN	_	16	acl	_	_
18	in	in	IN	IN	_	20	case	_	_
19	STAT1	stat1	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Compared	compare	VBN	VBN	_	21	advcl	_	_
2	with	with	IN	IN	_	3	case	_	_
3	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
4	adherent	adherent	JJ	JJ	_	3	amod	_	_
5	on	on	IN	IN	_	7	case	_	_
6	plastic	plastic	JJ	JJ	_	7	amod	_	_
7	surfaces	surface	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	21	punct	_	_
9	freshly	freshly	RB	RB	_	10	advmod	_	_
10	isolated	isolate	VBN	VBN	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	21	nsubj	_	_
12	allowed	allow	VBN	VBN	_	11	acl	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	adhere	adhere	VB	VB	_	12	xcomp	_	_
15	either	either	CC	CC	_	14	advcl	_	_
16	to	to	TO	TO	_	17	case	_	_
17	fibronectin-	fibronectin-	NN	NN	_	15	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	laminin-coated	laminin-coated	JJ	JJ	_	20	amod	_	_
20	flasks	flask	NNS	NNS	_	17	conj	_	_
21	exhibited	exhibit	VBD	VBD	_	0	root	_	_
22	an	a	DT	DT	_	26	det	_	_
23	increased	increase	VBN	VBN	_	26	amod	_	_
24	STAT1	stat1	NN	NN	_	26	compound	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	21	dobj	_	_
27	both	both	CC	CC	_	29	cc:preconj	_	_
28	in	in	IN	IN	_	29	case	_	_
29	control	control	NN	NN	_	26	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	in	in	IN	IN	_	33	case	_	_
32	IFN-gamma-treated	ifn-gamma-treated	JJ	JJ	_	33	amod	_	_
33	cells	cell	NNS	NNS	_	29	conj	_	_
34	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	events	event	NNS	NNS	_	12	nsubj	_	_
4	leading	lead	VBG	VBG	_	3	acl	_	_
5	to	to	TO	TO	_	8	case	_	_
6	enhanced	enhance	VBN	VBN	_	8	amod	_	_
7	STAT1	stat1	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	cytokine	cytokine	NN	NN	_	11	compound	_	_
11	responsiveness	responsiveness	NN	NN	_	8	conj	_	_
12	concerned	concern	VBD	VBD	_	0	root	_	_
13	both	both	CC	CC	_	14	cc:preconj	_	_
14	Y701	y701	NN	NN	_	12	dobj	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	S727	s727	NN	NN	_	14	conj	_	_
17	STAT1	stat1	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	14	dep	_	_
19	.	.	.	.	_	12	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	2	amod	_	_
2	addition	addition	NN	NN	_	19	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	transforming	transform	VBG	VBG	_	6	amod	_	_
5	growth	growth	NN	NN	_	6	compound	_	_
6	factor-beta	factor-beta	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	2	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	exerts	exert	VBZ	VBZ	_	2	acl:relcl	_	_
10	an	a	DT	DT	_	12	det	_	_
11	inhibitory	inhibitory	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	9	dobj	_	_
13	on	on	IN	IN	_	17	case	_	_
14	some	some	DT	DT	_	17	det	_	_
15	monocytic	monocytic	JJ	JJ	_	17	amod	_	_
16	differentiation	differentiation	NN	NN	_	17	compound	_	_
17	markers	marker	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	19	punct	_	_
19	inhibited	inhibit	VBD	VBD	_	0	root	_	_
20	macrophage	macrophage	NN	NN	_	21	compound	_	_
21	maturation	maturation	NN	NN	_	19	dobj	_	_
22	,	,	,	,	_	21	punct	_	_
23	integrin	integrin	NN	NN	_	24	compound	_	_
24	expression	expression	NN	NN	_	21	conj	_	_
25	and	and	CC	CC	_	21	cc	_	_
26	STAT1	stat1	NN	NN	_	28	compound	_	_
27	binding	binding	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	21	conj	_	_
29	.	.	.	.	_	19	punct	_	_

1	Taken	take	VBN	VBN	_	5	dep	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	STAT1	stat1	NN	NN	_	8	nsubj	_	_
8	plays	play	VBZ	VBZ	_	5	ccomp	_	_
9	a	a	DT	DT	_	11	det	_	_
10	pivotal	pivotal	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	differentiation/maturation	differentiation/maturation	NN	NN	_	15	compound	_	_
15	process	process	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
18	as	as	IN	IN	_	22	case	_	_
19	an	a	DT	DT	_	22	det	_	_
20	early	early	JJ	JJ	_	22	amod	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	11	nmod	_	_
23	initially	initially	RB	RB	_	24	advmod	_	_
24	activated	activate	VBN	VBN	_	22	acl	_	_
25	by	by	IN	IN	_	26	case	_	_
26	adherence	adherence	NN	NN	_	24	nmod	_	_
27	and	and	CC	CC	_	8	cc	_	_
28	then	then	RB	RB	_	29	advmod	_	_
29	able	able	JJ	JJ	_	8	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	modulate	modulate	VB	VB	_	29	xcomp	_	_
32	the	the	DT	DT	_	33	det	_	_
33	expression	expression	NN	NN	_	31	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	functional	functional	JJ	JJ	_	36	amod	_	_
36	genes	gene	NNS	NNS	_	33	nmod	_	_
37	,	,	,	,	_	36	punct	_	_
38	such	such	JJ	JJ	_	40	case	_	_
39	as	as	IN	IN	_	38	mwe	_	_
40	ICAM-1	icam-1	NN	NN	_	36	nmod	_	_
41	and	and	CC	CC	_	40	cc	_	_
42	FcgammaRI	fcgammari	NN	NN	_	40	conj	_	_
43	.	.	.	.	_	5	punct	_	_

1	Cutting	cutting	JJ	JJ	_	2	amod	_	_
2	edge	edge	NN	NN	_	0	root	_	_
3	:	:	:	:	_	2	punct	_	_
4	expression	expression	NN	NN	_	2	dep	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	NF	nf	NN	NN	_	11	compound	_	_
8	of	of	IN	IN	_	11	amod	_	_
9	activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	4	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	eosinophils	eosinophil	NNS	NNS	_	4	nmod	_	_
14	:	:	:	:	_	4	punct	_	_
15	regulation	regulation	NN	NN	_	2	dep	_	_
16	by	by	IN	IN	_	17	case	_	_
17	IL-4	il-4	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-5	il-5	NN	NN	_	17	conj	_	_
20	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	8	mark	_	_
4	NF-AT1	nf-at1	NN	NN	_	8	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-AT4	nf-at4	NN	NN	_	4	conj	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	expressed	express	VBN	VBN	_	2	ccomp	_	_
9	cytoplasmically	cytoplasmically	RB	RB	_	8	advmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	resting	rest	VBG	VBG	_	12	amod	_	_
12	eosinophils	eosinophil	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	8	punct	_	_
14	whereas	whereas	IN	IN	_	8	dep	_	_
15	NF-AT2	nf-at2	NN	NN	_	21	nsubjpass	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	NF-AT3	nf-at3	NN	NN	_	15	conj	_	_
18	have	have	VBP	VBP	_	21	aux	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	seen	see	VBN	VBN	_	8	parataxis	_	_
22	.	.	.	.	_	2	punct	_	_

1	Likewise	likewise	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	NF-AT1	nf-at1	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	10	nsubjpass	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	NF-AT4	nf-at4	NN	NN	_	7	compound	_	_
7	mRNA	mrna	NN	NN	_	4	conj	_	_
8	have	have	VBP	VBP	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	detected	detect	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	13	case	_	_
12	resting	rest	VBG	VBG	_	13	amod	_	_
13	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	levels	level	NNS	NNS	_	21	nsubjpass	_	_
18	can	can	MD	MD	_	21	aux	_	_
19	be	be	VB	VB	_	21	auxpass	_	_
20	significantly	significantly	RB	RB	_	21	advmod	_	_
21	up-regulated	up-regulate	VBN	VBN	_	10	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	Th2-associated	th2-associated	JJ	JJ	_	25	amod	_	_
25	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
26	IL-4	il-4	NN	NN	_	25	dep	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	IL-5	il-5	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	10	punct	_	_

1	There	there	EX	EX	_	2	expl	_	_
2	is	be	VBZ	VBZ	_	0	root	_	_
3	no	no	DT	DT	_	7	neg	_	_
4	detectable	detectable	JJ	JJ	_	7	amod	_	_
5	NF-AT	nf-at	NN	NN	_	7	compound	_	_
6	protein	protein	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	2	nsubj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nuclei	nucleus	NNS	NNS	_	2	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	resting	rest	VBG	VBG	_	13	amod	_	_
13	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	3	advmod	_	_
2	NF-ATs	nf-at	NNS	NNS	_	3	nsubj	_	_
3	appear	appear	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	nuclei	nucleus	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	IL-4-	il-4-	NN	NN	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	IL-5-	il-5-	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	or	or	CC	CC	_	8	cc	_	_
13	ionomycin-stimulated	ionomycin-stimulated	JJ	JJ	_	14	amod	_	_
14	eosinophils	eosinophil	NNS	NNS	_	8	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Only	only	RB	RB	_	2	advmod	_	_
2	NF-AT1	nf-at1	NN	NN	_	13	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-AT4	nf-at4	NN	NN	_	2	conj	_	_
5	,	,	,	,	_	2	punct	_	_
6	but	but	CC	CC	_	2	cc	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	NF-AT2	nf-at2	NN	NN	_	2	conj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	NF-AT3	nf-at3	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	2	punct	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	translocated	translocate	VBN	VBN	_	0	root	_	_
14	into	into	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	nuclei	nucleus	NNS	NNS	_	13	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	IL-4-	il-4-	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	IL-5-stimulated	il-5-stimulated	JJ	JJ	_	21	amod	_	_
21	eosinophils	eosinophil	NNS	NNS	_	18	conj	_	_
22	.	.	.	.	_	13	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	delineate	delineate	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	novel	novel	JJ	JJ	_	6	amod	_	_
6	pathway	pathway	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	cytokine	cytokine	NN	NN	_	10	compound	_	_
10	network	network	NN	NN	_	3	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	16	nmod	_	_
13	Th2	th2	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	16	nsubj	_	_
15	``	``	``	``	_	16	punct	_	_
16	control	control	VBP	VBP	_	10	acl:relcl	_	_
17	eosinophils	eosinophil	NNS	NNS	_	16	dobj	_	_
18	via	via	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	release	release	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	IL-4	il-4	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	IL-5	il-5	NN	NN	_	22	conj	_	_
25	,	,	,	,	_	20	punct	_	_
26	and	and	CC	CC	_	20	cc	_	_
27	activation	activation	NN	NN	_	20	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	NF-AT	nf-at	NN	NN	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	eosinophils	eosinophil	NNS	NNS	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	a	a	DT	DT	_	10	det	_	_
7	later	later	JJR	JJR	_	10	amod	_	_
8	feedback	feedback	NN	NN	_	10	compound	_	_
9	``	``	``	``	_	10	punct	_	_
10	talking	talking	NN	NN	_	12	nsubj	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	exist	exist	VB	VB	_	4	ccomp	_	_
13	between	between	IN	IN	_	14	case	_	_
14	eosinophils	eosinophil	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	Th2	th2	NN	NN	_	17	compound	_	_
17	lymphocytes	lymphocyte	NNS	NNS	_	14	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Altered	altered	JJ	JJ	_	5	amod	_	_
2	memory	memory	NN	NN	_	5	compound	_	_
3	T	t	NN	NN	_	5	compound	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	differentiation	differentiation	NN	NN	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	patients	patient	NNS	NNS	_	5	nmod	_	_
8	with	with	IN	IN	_	11	case	_	_
9	early	early	JJ	JJ	_	11	amod	_	_
10	rheumatoid	rheumatoid	JJ	JJ	_	11	amod	_	_
11	arthritis	arthritis	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	chronic	chronic	JJ	JJ	_	4	amod	_	_
3	immune	immune	JJ	JJ	_	4	amod	_	_
4	response	response	NN	NN	_	13	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	rheumatoid	rheumatoid	JJ	JJ	_	7	amod	_	_
7	arthritis	arthritis	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	RA	ra	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	might	might	MD	MD	_	13	aux	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	driven	drive	VBN	VBN	_	0	root	_	_
14	by	by	IN	IN	_	17	case	_	_
15	activated	activate	VBN	VBN	_	17	amod	_	_
16	Th1	th1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	without	without	IN	IN	_	22	case	_	_
19	sufficient	sufficient	JJ	JJ	_	22	amod	_	_
20	Th2	th2	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	differentiation	differentiation	NN	NN	_	13	nmod	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	down-modulate	down-modulate	VB	VB	_	22	acl	_	_
25	inflammation	inflammation	NN	NN	_	24	dobj	_	_
26	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	test	test	VB	VB	_	19	dep	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	disordered	disorder	VBN	VBN	_	8	amod	_	_
5	memory	memory	NN	NN	_	8	compound	_	_
6	T	t	NN	NN	_	8	compound	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	differentiation	differentiation	NN	NN	_	9	nsubj	_	_
9	contributes	contribute	VBZ	VBZ	_	2	ccomp	_	_
10	to	to	TO	TO	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	typical	typical	JJ	JJ	_	15	amod	_	_
13	Th1-dominated	th1-dominated	JJ	JJ	_	15	amod	_	_
14	chronic	chronic	JJ	JJ	_	15	amod	_	_
15	inflammation	inflammation	NN	NN	_	9	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	RA	ra	NN	NN	_	15	nmod	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	investigated	investigate	VBD	VBD	_	0	root	_	_
20	differentiation	differentiation	NN	NN	_	19	dobj	_	_
21	of	of	IN	IN	_	26	case	_	_
22	resting	rest	VBG	VBG	_	26	amod	_	_
23	CD4+	cd4+	JJ	JJ	_	26	amod	_	_
24	memory	memory	NN	NN	_	26	compound	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	20	nmod	_	_
27	in	in	IN	IN	_	28	case	_	_
28	patients	patient	NNS	NNS	_	19	nmod	_	_
29	with	with	IN	IN	_	39	case	_	_
30	early	early	JJ	JJ	_	39	amod	_	_
31	(	(	-LRB-	-LRB-	_	33	punct	_	_
32	6	6	CD	CD	_	33	nummod	_	_
33	wk	wk	NN	NN	_	30	dep	_	_
34	to	to	TO	TO	_	33	dep	_	_
35	12	12	CD	CD	_	36	nummod	_	_
36	mo	mo	NN	NN	_	33	dep	_	_
37	)	)	-RRB-	-RRB-	_	33	punct	_	_
38	untreated	untreated	JJ	JJ	_	39	amod	_	_
39	RA	ra	NN	NN	_	28	nmod	_	_
40	and	and	CC	CC	_	28	cc	_	_
41	in	in	IN	IN	_	46	case	_	_
42	age-	age-	NN	NN	_	46	amod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	sex-matched	sex-matched	JJ	JJ	_	42	conj	_	_
45	healthy	healthy	JJ	JJ	_	46	amod	_	_
46	controls	control	NNS	NNS	_	28	conj	_	_
47	in	in	FW	FW	_	48	compound	_	_
48	vitro	vitro	FW	FW	_	19	advmod	_	_
49	.	.	.	.	_	19	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	difference	difference	NN	NN	_	14	nsubjpass	_	_
3	in	in	IN	IN	_	6	case	_	_
4	cytokine	cytokine	NN	NN	_	6	compound	_	_
5	secretion	secretion	NN	NN	_	6	compound	_	_
6	profiles	profile	NNS	NNS	_	2	nmod	_	_
7	of	of	IN	IN	_	12	case	_	_
8	freshly	freshly	RB	RB	_	12	advmod	_	_
9	isolated	isolate	VBN	VBN	_	12	amod	_	_
10	memory	memory	NN	NN	_	12	compound	_	_
11	T	t	NN	NN	_	12	compound	_	_
12	cells	cell	NNS	NNS	_	6	nmod	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	detected	detect	VBN	VBN	_	0	root	_	_
15	between	between	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	controls	control	NNS	NNS	_	16	conj	_	_
19	.	.	.	.	_	14	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	culture	culture	NN	NN	_	4	compound	_	_
4	system	system	NN	NN	_	7	nsubjpass	_	_
5	was	be	VBD	VBD	_	7	auxpass	_	_
6	then	then	RB	RB	_	7	advmod	_	_
7	employed	employ	VBN	VBN	_	0	root	_	_
8	that	that	WDT	WDT	_	9	nsubj	_	_
9	permitted	permit	VBD	VBD	_	7	ccomp	_	_
10	the	the	DT	DT	_	11	det	_	_
11	differentiation	differentiation	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	Th	th	NN	NN	_	14	compound	_	_
14	effectors	effector	NNS	NNS	_	11	nmod	_	_
15	from	from	IN	IN	_	19	case	_	_
16	resting	rest	VBG	VBG	_	19	amod	_	_
17	memory	memory	NN	NN	_	19	compound	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	11	nmod	_	_
20	by	by	IN	IN	_	23	case	_	_
21	short	short	JJ	JJ	_	23	amod	_	_
22	term	term	NN	NN	_	23	compound	_	_
23	priming	priming	NN	NN	_	11	nmod	_	_
24	.	.	.	.	_	7	punct	_	_

1	Marked	marked	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	response	response	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	priming	priming	NN	NN	_	6	nmod	_	_
9	.	.	.	.	_	4	punct	_	_

1	Th2	th2	NN	NN	_	2	compound	_	_
2	cells	cell	NNS	NNS	_	5	nsubjpass	_	_
3	could	could	MD	MD	_	5	aux	_	_
4	be	be	VB	VB	_	5	auxpass	_	_
5	induced	induce	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	all	all	DT	DT	_	9	det	_	_
8	healthy	healthy	JJ	JJ	_	9	amod	_	_
9	controls	control	NNS	NNS	_	5	nmod	_	_
10	by	by	IN	IN	_	11	mark	_	_
11	priming	prime	VBG	VBG	_	5	advcl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	anti-CD28	anti-cd28	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	absence	absence	NN	NN	_	5	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	TCR	tcr	NN	NN	_	19	compound	_	_
19	ligation	ligation	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	By	by	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	priming	priming	NN	NN	_	8	csubj	_	_
5	under	under	IN	IN	_	7	case	_	_
6	those	those	DT	DT	_	7	det	_	_
7	conditions	condition	NNS	NNS	_	4	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	Th2	th2	NN	NN	_	11	compound	_	_
11	differentiation	differentiation	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	only	only	RB	RB	_	14	advmod	_	_
14	9	9	CD	CD	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	24	24	CD	CD	_	18	nummod	_	_
17	RA	ra	NN	NN	_	18	compound	_	_
18	patients	patient	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Exogenous	exogenous	JJ	JJ	_	2	amod	_	_
2	IL-4	il-4	NN	NN	_	4	nsubj	_	_
3	could	could	MD	MD	_	4	aux	_	_
4	overcome	overcome	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	9	det	_	_
6	apparent	apparent	JJ	JJ	_	9	amod	_	_
7	Th2	th2	NN	NN	_	9	compound	_	_
8	differentiation	differentiation	NN	NN	_	9	compound	_	_
9	defect	defect	NN	NN	_	4	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	seven	seven	CD	CD	_	12	nummod	_	_
12	patients	patient	NNS	NNS	_	4	nmod	_	_
13	but	but	CC	CC	_	4	cc	_	_
14	was	be	VBD	VBD	_	16	cop	_	_
15	without	without	IN	IN	_	16	case	_	_
16	effect	effect	NN	NN	_	4	conj	_	_
17	in	in	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	remaining	remain	VBG	VBG	_	21	amod	_	_
20	eight	eight	CD	CD	_	21	nummod	_	_
21	patients	patient	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	all	all	DT	DT	_	3	det	_	_
3	patients	patient	NNS	NNS	_	25	nmod	_	_
4	a	a	DT	DT	_	6	det	_	_
5	marked	marked	JJ	JJ	_	6	amod	_	_
6	decrease	decrease	NN	NN	_	25	nsubj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	IL-2-producing	il-2-producing	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	a	a	DT	DT	_	13	det	_	_
12	significant	significant	JJ	JJ	_	13	amod	_	_
13	increase	increase	NN	NN	_	6	conj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	well-differentiated	well-differentiated	JJ	JJ	_	17	amod	_	_
16	Th1	th1	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	produced	produce	VBD	VBD	_	17	acl:relcl	_	_
20	IFN-gamma	ifn-gamma	NN	NN	_	19	dobj	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	not	not	RB	RB	_	23	neg	_	_
23	IL-2	il-2	NN	NN	_	20	conj	_	_
24	were	be	VBD	VBD	_	25	cop	_	_
25	evident	evident	JJ	JJ	_	0	root	_	_
26	after	after	IN	IN	_	27	mark	_	_
27	priming	prime	VBG	VBG	_	25	advcl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	anti-CD3	anti-cd3	NN	NN	_	27	nmod	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	anti-CD28	anti-cd28	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	25	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	CD4+	cd4+	JJ	JJ	_	8	amod	_	_
6	memory	memory	NN	NN	_	8	compound	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	15	dep	_	_
9	from	from	IN	IN	_	10	case	_	_
10	patients	patient	NNS	NNS	_	8	nmod	_	_
11	with	with	IN	IN	_	14	case	_	_
12	early	early	JJ	JJ	_	14	amod	_	_
13	untreated	untreated	JJ	JJ	_	14	amod	_	_
14	RA	ra	NN	NN	_	10	nmod	_	_
15	manifest	manifest	VBP	VBP	_	3	dep	_	_
16	an	a	DT	DT	_	18	det	_	_
17	intrinsic	intrinsic	JJ	JJ	_	18	amod	_	_
18	abnormality	abnormality	NN	NN	_	15	dobj	_	_
19	in	in	IN	IN	_	21	case	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	ability	ability	NN	NN	_	18	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	differentiate	differentiate	VB	VB	_	21	acl	_	_
24	into	into	IN	IN	_	28	case	_	_
25	specific	specific	JJ	JJ	_	28	amod	_	_
26	cytokine-producing	cytokine-producing	JJ	JJ	_	28	amod	_	_
27	effector	effector	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	that	that	WDT	WDT	_	31	nsubj	_	_
30	might	might	MD	MD	_	31	aux	_	_
31	contribute	contribute	VB	VB	_	28	acl:relcl	_	_
32	to	to	TO	TO	_	41	case	_	_
33	the	the	DT	DT	_	41	det	_	_
34	characteristic	characteristic	JJ	JJ	_	41	amod	_	_
35	Th1-dominated	th1-dominated	JJ	JJ	_	41	amod	_	_
36	chronic	chronic	JJ	JJ	_	41	amod	_	_
37	(	(	-LRB-	-LRB-	_	41	punct	_	_
38	auto	auto	JJ	JJ	_	41	amod	_	_
39	)	)	-RRB-	-RRB-	_	41	punct	_	_
40	immune	immune	JJ	JJ	_	41	amod	_	_
41	inflammation	inflammation	NN	NN	_	31	nmod	_	_
42	in	in	IN	IN	_	43	case	_	_
43	RA	ra	NN	NN	_	41	nmod	_	_
44	.	.	.	.	_	3	punct	_	_

1	Functional	functional	JJ	JJ	_	3	amod	_	_
2	B-cell	b-cell	NN	NN	_	3	compound	_	_
3	response	response	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	7	case	_	_
5	intrahepatic	intrahepatic	JJ	JJ	_	7	amod	_	_
6	lymphoid	lymphoid	JJ	JJ	_	7	amod	_	_
7	follicles	follicle	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	11	case	_	_
9	chronic	chronic	JJ	JJ	_	11	amod	_	_
10	hepatitis	hepatitis	NN	NN	_	11	compound	_	_
11	C	c	NN	NN	_	7	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Intrahepatic	intrahepatic	JJ	JJ	_	3	amod	_	_
2	lymphoid	lymphoid	JJ	JJ	_	3	amod	_	_
3	follicle	follicle	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	ILF	ilf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	formation	formation	NN	NN	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	one	one	CD	CD	_	0	root	_	_
10	of	of	IN	IN	_	18	case	_	_
11	the	the	DT	DT	_	13	dep	_	_
12	most	most	RBS	RBS	_	13	advmod	_	_
13	characteristic	characteristic	JJ	JJ	_	18	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	commonly	commonly	RB	RB	_	16	advmod	_	_
16	observed	observe	VBN	VBN	_	13	conj	_	_
17	histological	histological	JJ	JJ	_	18	amod	_	_
18	features	feature	NNS	NNS	_	9	nmod	_	_
19	in	in	IN	IN	_	20	case	_	_
20	patients	patient	NNS	NNS	_	18	nmod	_	_
21	with	with	IN	IN	_	24	case	_	_
22	chronic	chronic	JJ	JJ	_	24	amod	_	_
23	hepatitis	hepatitis	NN	NN	_	24	compound	_	_
24	C	c	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	However	however	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	little	little	JJ	JJ	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	known	know	VBN	VBN	_	0	root	_	_
6	regarding	regard	VBG	VBG	_	12	case	_	_
7	whether	whether	IN	IN	_	12	mark	_	_
8	follicles	follicle	NNS	NNS	_	12	nsubj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	liver	liver	NN	NN	_	8	nmod	_	_
12	belong	belong	VBP	VBP	_	5	advcl	_	_
13	to	to	TO	TO	_	16	case	_	_
14	functional	functional	JJ	JJ	_	16	amod	_	_
15	lymphoid	lymphoid	JJ	JJ	_	16	amod	_	_
16	tissues	tissue	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	where	where	WRB	WRB	_	22	advmod	_	_
19	B	b	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	22	nsubjpass	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	activated	activate	VBN	VBN	_	16	acl:relcl	_	_
23	,	,	,	,	_	22	punct	_	_
24	differentiated	differentiate	VBN	VBN	_	22	conj	_	_
25	,	,	,	,	_	22	punct	_	_
26	and	and	CC	CC	_	22	cc	_	_
27	proliferated	proliferate	VBN	VBN	_	22	conj	_	_
28	,	,	,	,	_	12	punct	_	_
29	or	or	CC	CC	_	12	cc	_	_
30	if	if	IN	IN	_	35	mark	_	_
31	the	the	DT	DT	_	32	det	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	35	nsubjpass	_	_
33	are	be	VBP	VBP	_	35	auxpass	_	_
34	merely	merely	RB	RB	_	35	advmod	_	_
35	infiltrated	infiltrate	VBN	VBN	_	12	conj	_	_
36	after	after	IN	IN	_	37	case	_	_
37	recruitment	recruitment	NN	NN	_	35	nmod	_	_
38	from	from	IN	IN	_	42	case	_	_
39	the	the	DT	DT	_	42	det	_	_
40	secondary	secondary	JJ	JJ	_	42	amod	_	_
41	lymphoid	lymphoid	JJ	JJ	_	42	amod	_	_
42	organs	organ	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	ascertain	ascertain	VB	VB	_	7	advcl	_	_
3	this	this	DT	DT	_	4	dep	_	_
4	possibility	possibility	NN	NN	_	2	dep	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	examined	examine	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	markers	marker	NNS	NNS	_	9	nmod	_	_
12	for	for	IN	IN	_	14	case	_	_
13	B-cell	b-cell	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	differentiation	differentiation	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	proliferation	proliferation	NN	NN	_	14	conj	_	_
20	in	in	IN	IN	_	21	case	_	_
21	ILFs	ilf	NNS	NNS	_	14	nmod	_	_
22	in	in	IN	IN	_	23	case	_	_
23	patients	patient	NNS	NNS	_	21	nmod	_	_
24	with	with	IN	IN	_	27	case	_	_
25	chronic	chronic	JJ	JJ	_	27	amod	_	_
26	hepatitis	hepatitis	NN	NN	_	27	compound	_	_
27	C	c	NN	NN	_	23	nmod	_	_
28	using	use	VBG	VBG	_	7	xcomp	_	_
29	surgically	surgically	RB	RB	_	30	advmod	_	_
30	resected	resected	JJ	JJ	_	31	amod	_	_
31	specimens	specimen	NNS	NNS	_	28	dobj	_	_
32	,	,	,	,	_	7	punct	_	_
33	and	and	CC	CC	_	7	cc	_	_
34	compared	compare	VBD	VBD	_	7	conj	_	_
35	them	they	PRP	PRP	_	34	dobj	_	_
36	with	with	IN	IN	_	37	case	_	_
37	specimens	specimen	NNS	NNS	_	34	nmod	_	_
38	of	of	IN	IN	_	41	case	_	_
39	perihepatic	perihepatic	JJ	JJ	_	41	amod	_	_
40	lymph	lymph	NN	NN	_	41	compound	_	_
41	nodes	node	NNS	NNS	_	37	nmod	_	_
42	by	by	IN	IN	_	45	case	_	_
43	an	a	DT	DT	_	45	det	_	_
44	immunohistochemical	immunohistochemical	JJ	JJ	_	45	amod	_	_
45	technique	technique	NN	NN	_	34	nmod	_	_
46	.	.	.	.	_	7	punct	_	_

1	Germinal	germinal	JJ	JJ	_	2	amod	_	_
2	center	center	NN	NN	_	6	compound	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	GC	gc	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	formation	formation	NN	NN	_	12	nsubjpass	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	ILFs	ilf	NNS	NNS	_	6	nmod	_	_
10	was	be	VBD	VBD	_	12	auxpass	_	_
11	frequently	frequently	RB	RB	_	12	advmod	_	_
12	found	find	VBN	VBN	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	HCV-positive	hcv-positive	JJ	JJ	_	15	amod	_	_
15	cases	case	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	distribution	distribution	NN	NN	_	47	nsubj	_	_
3	of	of	IN	IN	_	15	amod	_	_
4	immunoglobulin	immunoglobulin	NN	NN	_	15	compound	_	_
5	M	m	NN	NN	_	7	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IgM	igm	NN	NN	_	15	amod	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	-	-	:	:	_	7	punct	_	_
10	,	,	,	,	_	7	punct	_	_
11	IgD-	igd-	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	7	punct	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	IgG-positive	igg-positive	JJ	JJ	_	7	conj	_	_
15	cells	cell	NNS	NNS	_	2	dep	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	expression	expression	NN	NN	_	19	compound	_	_
19	patterns	pattern	NNS	NNS	_	2	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	Ki-67	ki-67	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	CD23	cd23	NN	NN	_	21	conj	_	_
24	,	,	,	,	_	21	punct	_	_
25	or	or	CC	CC	_	21	cc	_	_
26	bcl-2	bcl-2	NN	NN	_	21	conj	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	bcl-6	bcl-6	JJ	JJ	_	26	conj	_	_
29	gene	gene	NN	NN	_	30	compound	_	_
30	products	product	NNS	NNS	_	26	dep	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	follicles	follicle	NNS	NNS	_	2	nmod	_	_
34	with	with	IN	IN	_	36	case	_	_
35	GC	gc	NN	NN	_	36	compound	_	_
36	formation	formation	NN	NN	_	33	nmod	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	liver	liver	NN	NN	_	33	nmod	_	_
40	of	of	IN	IN	_	41	case	_	_
41	patients	patient	NNS	NNS	_	39	nmod	_	_
42	with	with	IN	IN	_	45	case	_	_
43	chronic	chronic	JJ	JJ	_	45	amod	_	_
44	hepatitis	hepatitis	NN	NN	_	45	compound	_	_
45	C	c	NN	NN	_	41	nmod	_	_
46	were	be	VBD	VBD	_	47	cop	_	_
47	similar	similar	JJ	JJ	_	0	root	_	_
48	to	to	TO	TO	_	49	case	_	_
49	those	those	DT	DT	_	47	nmod	_	_
50	of	of	IN	IN	_	52	case	_	_
51	lymph	lymph	NN	NN	_	52	compound	_	_
52	nodes	node	NNS	NNS	_	49	nmod	_	_
53	,	,	,	,	_	47	punct	_	_
54	indicating	indicate	VBG	VBG	_	47	dep	_	_
55	that	that	IN	IN	_	59	mark	_	_
56	B	b	NN	NN	_	57	compound	_	_
57	cells	cell	NNS	NNS	_	59	nsubjpass	_	_
58	are	be	VBP	VBP	_	59	auxpass	_	_
59	activated	activate	VBN	VBN	_	54	ccomp	_	_
60	,	,	,	,	_	59	punct	_	_
61	proliferated	proliferate	VBN	VBN	_	59	conj	_	_
62	,	,	,	,	_	59	punct	_	_
63	and	and	CC	CC	_	59	cc	_	_
64	differentiated	differentiate	VBN	VBN	_	59	conj	_	_
65	in	in	IN	IN	_	67	case	_	_
66	the	the	DT	DT	_	67	det	_	_
67	ILFs	ilf	NNS	NNS	_	59	nmod	_	_
68	with	with	IN	IN	_	70	case	_	_
69	GC	gc	NN	NN	_	70	compound	_	_
70	formation	formation	NN	NN	_	67	nmod	_	_
71	in	in	IN	IN	_	72	case	_	_
72	patients	patient	NNS	NNS	_	67	nmod	_	_
73	with	with	IN	IN	_	76	case	_	_
74	chronic	chronic	JJ	JJ	_	76	amod	_	_
75	hepatitis	hepatitis	NN	NN	_	76	compound	_	_
76	C	c	NN	NN	_	72	nmod	_	_
77	.	.	.	.	_	47	punct	_	_

1	Oligoclonal	oligoclonal	JJ	JJ	_	2	amod	_	_
2	expansion	expansion	NN	NN	_	12	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	livers	liver	NNS	NNS	_	5	nmod	_	_
9	with	with	IN	IN	_	10	case	_	_
10	ILFs	ilf	NNS	NNS	_	8	nmod	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	confirmed	confirm	VBN	VBN	_	0	root	_	_
13	by	by	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	analysis	analysis	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	24	case	_	_
17	immunoglobulin	immunoglobulin	NN	NN	_	19	compound	_	_
18	heavy	heavy	JJ	JJ	_	19	amod	_	_
19	chain	chain	NN	NN	_	24	compound	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	IgH	igh	JJ	JJ	_	19	dep	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	gene	gene	NN	NN	_	24	compound	_	_
24	rearrangement	rearrangement	NN	NN	_	15	nmod	_	_
25	determined	determine	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	29	case	_	_
27	polymerase	polymerase	NN	NN	_	29	compound	_	_
28	chain	chain	NN	NN	_	29	compound	_	_
29	reaction	reaction	NN	NN	_	25	nmod	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PCR	pcr	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	strongly	strongly	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	26	mark	_	_
6	ILFs	ilf	NNS	NNS	_	26	nsubj	_	_
7	with	with	IN	IN	_	9	case	_	_
8	GC	gc	NN	NN	_	9	compound	_	_
9	formation	formation	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	which	which	WDT	WDT	_	14	nsubjpass	_	_
12	are	be	VBP	VBP	_	14	auxpass	_	_
13	frequently	frequently	RB	RB	_	14	advmod	_	_
14	found	find	VBN	VBN	_	6	acl:relcl	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	with	with	IN	IN	_	20	case	_	_
18	chronic	chronic	JJ	JJ	_	20	amod	_	_
19	hepatitis	hepatitis	NN	NN	_	20	compound	_	_
20	C	c	NN	NN	_	16	nmod	_	_
21	,	,	,	,	_	26	punct	_	_
22	may	may	MD	MD	_	26	aux	_	_
23	functionally	functionally	RB	RB	_	26	advmod	_	_
24	be	be	VB	VB	_	26	cop	_	_
25	the	the	DT	DT	_	26	det	_	_
26	same	same	JJ	JJ	_	4	ccomp	_	_
27	as	as	IN	IN	_	28	case	_	_
28	those	those	DT	DT	_	26	nmod	_	_
29	found	find	VBN	VBN	_	28	acl	_	_
30	in	in	IN	IN	_	32	case	_	_
31	lymph	lymph	NN	NN	_	32	compound	_	_
32	nodes	node	NNS	NNS	_	29	nmod	_	_
33	with	with	IN	IN	_	34	case	_	_
34	respect	respect	NN	NN	_	32	nmod	_	_
35	to	to	TO	TO	_	37	case	_	_
36	B-cell	b-cell	NN	NN	_	37	compound	_	_
37	expansion	expansion	NN	NN	_	34	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	maturation	maturation	NN	NN	_	37	conj	_	_
40	.	.	.	.	_	4	punct	_	_

1	Ovarian	ovarian	JJ	JJ	_	6	compound	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	breast	breast	NN	NN	_	1	conj	_	_
4	cytotoxic	cytotoxic	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	8	nsubj	_	_
7	can	can	MD	MD	_	8	aux	_	_
8	recognize	recognize	VB	VB	_	0	root	_	_
9	peptides	peptide	NNS	NNS	_	8	dobj	_	_
10	from	from	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	amino	amino	NN	NN	_	13	compound	_	_
13	enhancer	enhancer	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	split	split	JJ	JJ	_	16	amod	_	_
16	protein	protein	NN	NN	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Notch	notch	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	investigated	investigate	VBD	VBD	_	0	root	_	_
6	recognition	recognition	NN	NN	_	5	dobj	_	_
7	by	by	IN	IN	_	11	case	_	_
8	ovarian	ovarian	JJ	JJ	_	11	amod	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	associated	associated	JJ	JJ	_	11	amod	_	_
11	lymphocyte	lymphocyte	NN	NN	_	5	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	OVTAL	ovtal	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	breast	breast	NN	NN	_	20	compound	_	_
18	tumor	tumor	NN	NN	_	20	compound	_	_
19	associated	associated	JJ	JJ	_	20	amod	_	_
20	lymphocytes	lymphocyte	NNS	NNS	_	11	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	BRTAL	brtal	NNS	NNS	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	11	punct	_	_
25	of	of	IN	IN	_	26	case	_	_
26	peptides	peptide	NNS	NNS	_	11	nmod	_	_
27	corresponding	correspond	VBG	VBG	_	40	case	_	_
28	to	to	TO	TO	_	40	case	_	_
29	the	the	DT	DT	_	40	det	_	_
30	sequence	sequence	NN	NN	_	40	compound	_	_
31	125-135	125-135	CD	CD	_	40	nummod	_	_
32	of	of	IN	IN	_	40	amod	_	_
33	the	the	DT	DT	_	40	det	_	_
34	Aminoenhancer	aminoenhancer	NN	NN	_	40	compound	_	_
35	of	of	IN	IN	_	40	amod	_	_
36	split	split	JJ	JJ	_	40	amod	_	_
37	(	(	-LRB-	-LRB-	_	40	punct	_	_
38	AES	aes	NN	NN	_	40	compound	_	_
39	)	)	-RRB-	-RRB-	_	40	punct	_	_
40	protein	protein	NN	NN	_	26	acl	_	_
41	.	.	.	.	_	5	punct	_	_

1	Three	three	CD	CD	_	21	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	peptides	peptide	NNS	NNS	_	1	nmod	_	_
5	designated	designate	VBN	VBN	_	1	acl	_	_
6	as	as	IN	IN	_	7	case	_	_
7	G75:AES1/2	g75:aes1/2	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	128-135	128-135	CD	CD	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	7	punct	_	_
12	G60:AES1/2	g60:aes1/2	NN	NN	_	7	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	127-137	127-137	CD	CD	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	G61:AES1/2	g61:aes1/2	NN	NN	_	7	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	125-133	125-133	CD	CD	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	correspond	correspond	VBP	VBP	_	0	root	_	_
22	to	to	TO	TO	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	wildtype	wildtype	JJ	JJ	_	26	amod	_	_
25	AES	aes	NN	NN	_	26	compound	_	_
26	sequence	sequence	NN	NN	_	21	nmod	_	_
27	,	,	,	,	_	21	punct	_	_
28	while	while	IN	IN	_	37	mark	_	_
29	the	the	DT	DT	_	33	det	_	_
30	fourth	fourth	JJ	JJ	_	33	amod	_	_
31	G76:GPLTPLPV	g76:gpltplpv	NN	NN	_	33	compound	_	_
32	,	,	,	,	_	33	punct	_	_
33	AES1/2	aes1/2	NN	NN	_	37	nsubj	_	_
34	(	(	-LRB-	-LRB-	_	33	punct	_	_
35	128-135	128-135	CD	CD	_	33	nummod	_	_
36	)	)	-RRB-	-RRB-	_	33	punct	_	_
37	corresponds	correspond	VBZ	VBZ	_	21	advcl	_	_
38	to	to	TO	TO	_	41	case	_	_
39	a	a	DT	DT	_	41	det	_	_
40	variant	variant	JJ	JJ	_	41	amod	_	_
41	sequence	sequence	NN	NN	_	37	nmod	_	_
42	of	of	IN	IN	_	45	case	_	_
43	the	the	DT	DT	_	45	det	_	_
44	peptide	peptide	NN	NN	_	45	compound	_	_
45	G75	g75	NN	NN	_	41	nmod	_	_
46	with	with	IN	IN	_	49	case	_	_
47	the	the	DT	DT	_	49	det	_	_
48	N-terminal	n-terminal	JJ	JJ	_	49	amod	_	_
49	Leu	leu	NN	NN	_	45	nmod	_	_
50	substituted	substitute	VBN	VBN	_	49	acl	_	_
51	to	to	TO	TO	_	52	case	_	_
52	glycine	glycine	NN	NN	_	50	nmod	_	_
53	.	.	.	.	_	21	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	sequences	sequence	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	chosen	choose	VBN	VBN	_	33	dep	_	_
5	for	for	IN	IN	_	6	case	_	_
6	study	study	NN	NN	_	4	nmod	_	_
7	because	because	IN	IN	_	27	dep	_	_
8	mass-spectrometric	mass-spectrometric	JJ	JJ	_	9	amod	_	_
9	analysis	analysis	NN	NN	_	27	dep	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	MS	ms	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	of	of	IN	IN	_	19	case	_	_
14	a	a	DT	DT	_	19	det	_	_
15	CTL	ctl	NN	NN	_	19	compound	_	_
16	active	active	JJ	JJ	_	19	amod	_	_
17	HPLC	hplc	NN	NN	_	19	compound	_	_
18	peptide	peptide	NN	NN	_	19	compound	_	_
19	fraction	fraction	NN	NN	_	9	nmod	_	_
20	eluted	elute	VBN	VBN	_	19	acl	_	_
21	from	from	IN	IN	_	25	case	_	_
22	immunoaffinity	immunoaffinity	NN	NN	_	25	compound	_	_
23	precipitated	precipitated	JJ	JJ	_	25	amod	_	_
24	HLA-A2	hla-a2	NN	NN	_	25	compound	_	_
25	molecule	molecule	NN	NN	_	20	nmod	_	_
26	,	,	,	,	_	9	punct	_	_
27	revealed	reveal	VBD	VBD	_	4	advcl	_	_
28	:	:	:	:	_	4	punct	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	a	a	LS	LS	_	33	dep	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	the	the	DT	DT	_	33	det	_	_
33	presence	presence	NN	NN	_	0	root	_	_
34	of	of	IN	IN	_	36	case	_	_
35	an	a	DT	DT	_	36	det	_	_
36	ion	ion	NN	NN	_	33	nmod	_	_
37	with	with	IN	IN	_	40	case	_	_
38	a	a	DT	DT	_	40	det	_	_
39	mass-to-charge	mass-to-charge	JJ	JJ	_	40	amod	_	_
40	ratio	ratio	NN	NN	_	33	nmod	_	_
41	(	(	-LRB-	-LRB-	_	42	punct	_	_
42	m/z	m/z	NN	NN	_	40	appos	_	_
43	)	)	-RRB-	-RRB-	_	42	punct	_	_
44	of	of	IN	IN	_	45	case	_	_
45	793	793	CD	CD	_	40	nmod	_	_
46	which	which	WDT	WDT	_	49	nsubj	_	_
47	was	be	VBD	VBD	_	49	cop	_	_
48	more	more	RBR	RBR	_	49	advmod	_	_
49	abundant	abundant	JJ	JJ	_	45	acl:relcl	_	_
50	than	than	IN	IN	_	52	case	_	_
51	other	other	JJ	JJ	_	52	amod	_	_
52	ions	ion	NNS	NNS	_	49	nmod	_	_
53	of	of	IN	IN	_	55	case	_	_
54	similar	similar	JJ	JJ	_	55	amod	_	_
55	masses	mass	NNS	NNS	_	52	nmod	_	_
56	;	;	:	:	_	33	punct	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	b	b	LS	LS	_	68	dep	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	the	the	DT	DT	_	63	det	_	_
61	tentatively	tentatively	RB	RB	_	62	advmod	_	_
62	reconstituted	reconstitute	VBN	VBN	_	63	amod	_	_
63	sequence	sequence	NN	NN	_	68	nsubj	_	_
64	of	of	IN	IN	_	66	case	_	_
65	the	the	DT	DT	_	66	det	_	_
66	ion	ion	NN	NN	_	63	nmod	_	_
67	793	793	CD	CD	_	66	nummod	_	_
68	matched	match	VBD	VBD	_	33	dep	_	_
69	the	the	DT	DT	_	70	det	_	_
70	sequence	sequence	NN	NN	_	68	dobj	_	_
71	of	of	IN	IN	_	73	case	_	_
72	peptide	peptide	NN	NN	_	73	compound	_	_
73	G76	g76	NN	NN	_	70	nmod	_	_
74	.	.	.	.	_	33	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	18	mark	_	_
4	AES	aes	NN	NN	_	5	compound	_	_
5	peptides	peptide	NNS	NNS	_	18	nsubj	_	_
6	G75	g75	NN	NN	_	5	dep	_	_
7	(	(	-LRB-	-LRB-	_	6	punct	_	_
8	128-135	128-135	CD	CD	_	6	nummod	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	G76	g76	NN	NN	_	16	compound	_	_
12	(	(	-LRB-	-LRB-	_	16	punct	_	_
13	128-135	128-135	CD	CD	_	16	nummod	_	_
14	)	)	-RRB-	-RRB-	_	16	punct	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	L128G	l128g	NN	NN	_	6	conj	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	reconstituted	reconstitute	VBD	VBD	_	2	ccomp	_	_
19	CTL	ctl	NN	NN	_	20	compound	_	_
20	recognition	recognition	NN	NN	_	18	dobj	_	_
21	at	at	IN	IN	_	22	case	_	_
22	concentrations	concentration	NNS	NNS	_	18	nmod	_	_
23	ranging	range	VBG	VBG	_	22	acl	_	_
24	between	between	IN	IN	_	26	case	_	_
25	200-500	200-500	CD	CD	_	26	nummod	_	_
26	nM	nm	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	concentrations	concentration	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	lower	lower	JJR	JJR	_	0	root	_	_
5	than	than	IN	IN	_	6	case	_	_
6	concentrations	concentration	NNS	NNS	_	4	nmod	_	_
7	reported	report	VBN	VBN	_	6	acl	_	_
8	to	to	TO	TO	_	9	mark	_	_
9	activate	activate	VB	VB	_	7	xcomp	_	_
10	effector	effector	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	18	case	_	_
13	CTL	ctl	NN	NN	_	18	compound	_	_
14	recognizing	recognize	VBG	VBG	_	18	amod	_	_
15	other	other	JJ	JJ	_	18	amod	_	_
16	epithelial	epithelial	JJ	JJ	_	18	amod	_	_
17	tumor	tumor	NN	NN	_	18	compound	_	_
18	Ag	ag	NN	NN	_	11	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	analysis	analysis	NN	NN	_	9	nsubj	_	_
4	with	with	IN	IN	_	8	case	_	_
5	cloned	clone	VBN	VBN	_	8	amod	_	_
6	CD8+	cd8+	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	3	nmod	_	_
9	indicated	indicate	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	G75	g75	NN	NN	_	17	nsubj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	G76	g76	NN	NN	_	11	conj	_	_
14	were	be	VBD	VBD	_	17	cop	_	_
15	not	not	RB	RB	_	17	neg	_	_
16	cross-reactive	cross-reactive	JJ	JJ	_	17	amod	_	_
17	specificities	specificity	NNS	NNS	_	9	ccomp	_	_
18	,	,	,	,	_	17	punct	_	_
19	suggesting	suggest	VBG	VBG	_	17	advcl	_	_
20	a	a	DT	DT	_	22	det	_	_
21	key	key	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	19	dobj	_	_
23	for	for	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	N-terminal	n-terminal	JJ	JJ	_	26	amod	_	_
26	residues	residue	NNS	NNS	_	22	nmod	_	_
27	of	of	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	variant	variant	JJ	JJ	_	30	amod	_	_
30	peptide	peptide	NN	NN	_	26	nmod	_	_
31	in	in	IN	IN	_	32	mark	_	_
32	dictating	dictate	VBG	VBG	_	22	acl	_	_
33	specificities	specificity	NNS	NNS	_	32	dobj	_	_
34	.	.	.	.	_	9	punct	_	_

1	Since	since	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	AES	aes	NN	NN	_	4	compound	_	_
4	proteins	protein	NNS	NNS	_	6	nsubj	_	_
5	are	be	VBP	VBP	_	6	cop	_	_
6	part	part	NN	NN	_	45	advcl	_	_
7	of	of	IN	IN	_	9	case	_	_
8	a	a	DT	DT	_	9	det	_	_
9	set	set	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	transcriptional	transcriptional	JJ	JJ	_	12	amod	_	_
12	repressors	repressor	NNS	NNS	_	9	nmod	_	_
13	encoded	encode	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	22	case	_	_
15	the	the	DT	DT	_	22	det	_	_
16	Enhancer	enhancer	NN	NN	_	22	compound	_	_
17	of	of	IN	IN	_	22	amod	_	_
18	split	split	JJ	JJ	_	22	amod	_	_
19	-LSB-	-lsb-	-LRB-	-LRB-	_	22	punct	_	_
20	E(spl)	e(spl)	NN	NN	_	22	compound	_	_
21	-RSB-	-rsb-	-RRB-	-RRB-	_	22	punct	_	_
22	genes	gene	NNS	NNS	_	13	nmod	_	_
23	,	,	,	,	_	6	punct	_	_
24	and	and	CC	CC	_	6	cc	_	_
25	since	since	IN	IN	_	29	mark	_	_
26	these	these	DT	DT	_	27	det	_	_
27	repressors	repressor	NNS	NNS	_	29	nsubjpass	_	_
28	are	be	VBP	VBP	_	29	auxpass	_	_
29	activated	activate	VBN	VBN	_	6	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	suppress	suppress	VB	VB	_	29	xcomp	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	differentiation	differentiation	NN	NN	_	31	dobj	_	_
34	in	in	IN	IN	_	35	case	_	_
35	response	response	NN	NN	_	31	nmod	_	_
36	to	to	TO	TO	_	39	case	_	_
37	Notch	notch	NN	NN	_	39	compound	_	_
38	receptors	receptor	NNS	NNS	_	39	compound	_	_
39	signalling	signalling	NN	NN	_	35	nmod	_	_
40	,	,	,	,	_	29	punct	_	_
41	the	the	DT	DT	_	43	det	_	_
42	AES	aes	NN	NN	_	43	compound	_	_
43	peptides	peptide	NNS	NNS	_	45	nsubj	_	_
44	may	may	MD	MD	_	45	aux	_	_
45	represent	represent	VB	VB	_	0	root	_	_
46	a	a	DT	DT	_	48	det	_	_
47	novel	novel	JJ	JJ	_	48	amod	_	_
48	class	class	NN	NN	_	45	dobj	_	_
49	of	of	IN	IN	_	50	case	_	_
50	self-antigens	self-antigen	NNS	NNS	_	48	nmod	_	_
51	that	that	WDT	WDT	_	52	nsubj	_	_
52	deserve	deserve	VBP	VBP	_	50	acl:relcl	_	_
53	further	further	JJ	JJ	_	54	amod	_	_
54	consideration	consideration	NN	NN	_	52	dobj	_	_
55	as	as	IN	IN	_	57	case	_	_
56	tumor	tumor	NN	NN	_	57	compound	_	_
57	Ag	ag	NN	NN	_	52	nmod	_	_
58	in	in	IN	IN	_	60	case	_	_
59	epithelial	epithelial	JJ	JJ	_	60	amod	_	_
60	cancers	cancer	NNS	NNS	_	57	nmod	_	_
61	.	.	.	.	_	45	punct	_	_

1	Inhibition	inhibition	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	T	t	NN	NN	_	9	compound	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	1	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	caspase-dependent	caspase-dependent	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
13	without	without	IN	IN	_	15	case	_	_
14	detectable	detectable	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	10	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	caspase-1	caspase-1	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	-3	-3	CD	CD	_	17	conj	_	_
20	.	.	.	.	_	10	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	2	compound	_	_
2	B	b	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	involved	involve	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	transcriptional	transcriptional	JJ	JJ	_	8	amod	_	_
8	control	control	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	various	various	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	act	act	VBP	VBP	_	11	acl:relcl	_	_
14	as	as	IN	IN	_	19	case	_	_
15	extrinsic	extrinsic	JJ	JJ	_	19	amod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	intrinsic	intrinsic	JJ	JJ	_	15	conj	_	_
18	survival	survival	NN	NN	_	19	compound	_	_
19	factors	factor	NNS	NNS	_	13	nmod	_	_
20	for	for	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	31	mark	_	_
5	suppression	suppression	NN	NN	_	31	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
8	B	b	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	5	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	cell-permeable	cell-permeable	JJ	JJ	_	13	amod	_	_
12	SN50	sn50	NN	NN	_	13	compound	_	_
13	peptide	peptide	NN	NN	_	5	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	masks	mask	VBZ	VBZ	_	13	acl:relcl	_	_
17	the	the	DT	DT	_	20	det	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	localization	localization	NN	NN	_	20	compound	_	_
20	sequence	sequence	NN	NN	_	16	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	NF-kappa	nf-kappa	NN	NN	_	24	compound	_	_
23	B1	b1	NN	NN	_	24	compound	_	_
24	dimers	dimer	NNS	NNS	_	20	nmod	_	_
25	and	and	CC	CC	_	16	cc	_	_
26	prevents	prevent	VBZ	VBZ	_	16	conj	_	_
27	their	they	PRP$	PRP$	_	29	nmod:poss	_	_
28	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
29	localization	localization	NN	NN	_	26	dobj	_	_
30	,	,	,	,	_	5	punct	_	_
31	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
32	apoptosis	apoptosis	NN	NN	_	31	dobj	_	_
33	in	in	IN	IN	_	37	case	_	_
34	resting	rest	VBG	VBG	_	37	amod	_	_
35	normal	normal	JJ	JJ	_	37	amod	_	_
36	human	human	JJ	JJ	_	37	amod	_	_
37	PBL	pbl	NN	NN	_	31	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Inhibition	inhibition	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
4	B	b	NN	NN	_	1	nmod	_	_
5	resulted	result	VBD	VBD	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	externalization	externalization	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	phosphatidylserine	phosphatidylserine	NN	NN	_	8	nmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	induction	induction	NN	NN	_	8	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	DNA	dna	NN	NN	_	15	compound	_	_
15	breaks	break	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	morphological	morphological	JJ	JJ	_	19	amod	_	_
19	changes	change	NNS	NNS	_	8	conj	_	_
20	consistent	consistent	JJ	JJ	_	19	amod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	apoptosis	apoptosis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	DNA	dna	NN	NN	_	2	compound	_	_
2	fragmentation	fragmentation	NN	NN	_	5	nsubjpass	_	_
3	was	be	VBD	VBD	_	5	auxpass	_	_
4	efficiently	efficiently	RB	RB	_	5	advmod	_	_
5	blocked	block	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	caspase	caspase	NN	NN	_	10	compound	_	_
9	inhibitor	inhibitor	NN	NN	_	10	compound	_	_
10	Z-VAD-fmk	z-vad-fmk	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	partially	partially	RB	RB	_	13	advmod	_	_
13	blocked	block	VBN	VBN	_	5	conj	_	_
14	by	by	IN	IN	_	15	case	_	_
15	Ac-DEVD-fmk	ac-devd-fmk	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	suggesting	suggest	VBG	VBG	_	5	advcl	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	SN50-mediated	sn50-mediated	JJ	JJ	_	20	amod	_	_
20	apoptosis	apoptosis	NN	NN	_	22	nsubj	_	_
21	is	be	VBZ	VBZ	_	22	cop	_	_
22	caspase-dependent	caspase-dependent	JJ	JJ	_	17	ccomp	_	_
23	.	.	.	.	_	5	punct	_	_

1	Interestingly	interestingly	RB	RB	_	30	advmod	_	_
2	,	,	,	,	_	30	punct	_	_
3	apoptosis	apoptosis	NN	NN	_	30	nsubjpass	_	_
4	induced	induce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	NF-kappa	nf-kappa	NN	NN	_	8	compound	_	_
7	B	b	NN	NN	_	8	compound	_	_
8	suppression	suppression	NN	NN	_	4	nmod	_	_
9	,	,	,	,	_	30	punct	_	_
10	in	in	IN	IN	_	11	case	_	_
11	contrast	contrast	NN	NN	_	30	nmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	that	that	DT	DT	_	11	nmod	_	_
14	induced	induce	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	TPEN	tpen	NN	NN	_	14	nmod	_	_
17	(	(	-LRB-	-LRB-	_	19	punct	_	_
18	N,N,N',N'-tetrakis	n,n,n',n'-tetrakis	JJ	JJ	_	19	amod	_	_
19	-LSB-2-pyridylmethyl-RSB-ethylenediamine	-lsb-2-pyridylmethyl-rsb-ethylenediamine	NN	NN	_	16	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	or	or	CC	CC	_	16	cc	_	_
22	soluble	soluble	JJ	JJ	_	24	amod	_	_
23	Fas	fas	NN	NN	_	24	compound	_	_
24	ligand	ligand	NN	NN	_	16	conj	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	CD95	cd95	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	,	,	,	,	_	30	punct	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	observed	observe	VBN	VBN	_	0	root	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	absence	absence	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	38	case	_	_
35	active	active	JJ	JJ	_	38	amod	_	_
36	death	death	NN	NN	_	38	compound	_	_
37	effector	effector	NN	NN	_	38	compound	_	_
38	proteases	protease	NNS	NNS	_	33	nmod	_	_
39	caspase-1-like	caspase-1-like	JJ	JJ	_	38	dep	_	_
40	(	(	-LRB-	-LRB-	_	43	punct	_	_
41	IL-1	il-1	NN	NN	_	43	compound	_	_
42	converting	converting	NN	NN	_	43	compound	_	_
43	enzyme	enzyme	NN	NN	_	39	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	,	,	,	,	_	39	punct	_	_
46	caspase-3-like	caspase-3-like	JJ	JJ	_	39	conj	_	_
47	(	(	-LRB-	-LRB-	_	48	punct	_	_
48	CPP32/Yama/apopain	cpp32/yama/apopain	NN	NN	_	46	appos	_	_
49	)	)	-RRB-	-RRB-	_	48	punct	_	_
50	,	,	,	,	_	39	punct	_	_
51	and	and	CC	CC	_	39	cc	_	_
52	caspase-6-like	caspase-6-like	JJ	JJ	_	39	conj	_	_
53	and	and	CC	CC	_	30	cc	_	_
54	without	without	IN	IN	_	55	case	_	_
55	cleavage	cleavage	NN	NN	_	30	conj	_	_
56	of	of	IN	IN	_	58	case	_	_
57	caspase-3	caspase-3	NN	NN	_	58	compound	_	_
58	substrates	substrate	NNS	NNS	_	55	nmod	_	_
59	poly(ADP-ribose)	poly(adp-ribose)	JJ	JJ	_	60	amod	_	_
60	polymerase	polymerase	NN	NN	_	58	dep	_	_
61	and	and	CC	CC	_	60	cc	_	_
62	DNA	dna	NN	NN	_	64	compound	_	_
63	fragmentation	fragmentation	NN	NN	_	64	compound	_	_
64	factor-45	factor-45	NN	NN	_	60	conj	_	_
65	.	.	.	.	_	30	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	either	either	CC	CC	_	10	cc:preconj	_	_
5	low	low	JJ	JJ	_	6	amod	_	_
6	level	level	NN	NN	_	10	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	activation	activation	NN	NN	_	6	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	required	require	VBN	VBN	_	3	ccomp	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	that	that	IN	IN	_	16	mark	_	_
13	different	different	JJ	JJ	_	14	amod	_	_
14	caspases	caspase	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	involved	involve	VBN	VBN	_	10	conj	_	_
17	.	.	.	.	_	3	punct	_	_

1	Preactivation	preactivation	NN	NN	_	11	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	1	nmod	_	_
5	resulting	result	VBG	VBG	_	1	acl	_	_
6	in	in	IN	IN	_	10	case	_	_
7	NF-kappa	nf-kappa	NN	NN	_	10	compound	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	translocation	translocation	NN	NN	_	5	nmod	_	_
11	protected	protect	VBD	VBD	_	0	root	_	_
12	cells	cell	NNS	NNS	_	11	dobj	_	_
13	from	from	IN	IN	_	15	case	_	_
14	SN50-induced	sn50-induced	JJ	JJ	_	15	amod	_	_
15	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	essential	essential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	NF-kappa	nf-kappa	NN	NN	_	9	compound	_	_
9	B	b	NN	NN	_	6	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	survival	survival	NN	NN	_	6	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	naive	naive	JJ	JJ	_	14	amod	_	_
14	PBL	pbl	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Signaling	signaling	NN	NN	_	2	compound	_	_
2	events	event	NNS	NNS	_	0	root	_	_
3	induced	induce	VBN	VBN	_	2	acl	_	_
4	by	by	IN	IN	_	7	case	_	_
5	lipopolysaccharide-activated	lipopolysaccharide-activated	JJ	JJ	_	7	amod	_	_
6	toll-like	toll-like	JJ	JJ	_	7	amod	_	_
7	receptor	receptor	NN	NN	_	3	nmod	_	_
8	2	2	CD	CD	_	7	nummod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Human	human	JJ	JJ	_	6	amod	_	_
2	Toll-like	toll-like	JJ	JJ	_	6	amod	_	_
3	receptor	receptor	NN	NN	_	6	compound	_	_
4	2	2	CD	CD	_	6	nummod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TLR2	tlr2	NN	NN	_	11	nsubj	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	signaling	signaling	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	0	root	_	_
12	that	that	WDT	WDT	_	13	nsubj	_	_
13	responds	respond	VBZ	VBZ	_	11	acl:relcl	_	_
14	to	to	TO	TO	_	15	case	_	_
15	LPS	lps	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	13	cc	_	_
17	activates	activate	VBZ	VBZ	_	13	conj	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	17	dobj	_	_
19	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigate	investigate	VBP	VBP	_	0	root	_	_
5	further	further	RBR	RBR	_	4	advmod	_	_
6	the	the	DT	DT	_	7	det	_	_
7	events	event	NNS	NNS	_	4	dobj	_	_
8	triggered	trigger	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	10	case	_	_
10	TLR2	tlr2	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	response	response	NN	NN	_	8	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	LPS	lps	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	TLR2	tlr2	NN	NN	_	5	nsubj	_	_
5	associates	associate	NNS	NNS	_	2	ccomp	_	_
6	with	with	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	high-affinity	high-affinity	JJ	JJ	_	13	amod	_	_
9	LPS	lps	NN	NN	_	13	compound	_	_
10	binding	binding	NN	NN	_	13	compound	_	_
11	protein	protein	NN	NN	_	13	compound	_	_
12	membrane	membrane	NN	NN	_	13	compound	_	_
13	CD14	cd14	NN	NN	_	5	nmod	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	serve	serve	VB	VB	_	5	xcomp	_	_
16	as	as	IN	IN	_	20	case	_	_
17	an	a	DT	DT	_	20	det	_	_
18	LPS	lps	NN	NN	_	20	compound	_	_
19	receptor	receptor	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	5	punct	_	_
22	and	and	CC	CC	_	5	cc	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	LPS	lps	NN	NN	_	25	compound	_	_
25	treatment	treatment	NN	NN	_	26	nsubj	_	_
26	enhances	enhance	VBZ	VBZ	_	5	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	oligomerization	oligomerization	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	TLR2	tlr2	NN	NN	_	28	nmod	_	_
31	.	.	.	.	_	2	punct	_	_

1	Concomitant	concomitant	JJ	JJ	_	4	case	_	_
2	with	with	IN	IN	_	4	case	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	oligomerization	oligomerization	NN	NN	_	13	advcl	_	_
5	,	,	,	,	_	13	punct	_	_
6	the	the	DT	DT	_	10	det	_	_
7	IL-1R-associated	il-1r-associated	JJ	JJ	_	10	amod	_	_
8	kinase	kinase	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IRAK	irak	NN	NN	_	13	nsubjpass	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	recruited	recruit	VBN	VBN	_	0	root	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	TLR2	tlr2	NN	NN	_	17	compound	_	_
17	complex	complex	NN	NN	_	13	nmod	_	_
18	.	.	.	.	_	13	punct	_	_

1	Intracellular	intracellular	JJ	JJ	_	3	amod	_	_
2	deletion	deletion	NN	NN	_	3	compound	_	_
3	variants	variant	NNS	NNS	_	12	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	TLR2	tlr2	NN	NN	_	3	nmod	_	_
6	lacking	lack	VBG	VBG	_	5	acl	_	_
7	C-terminal	c-terminal	JJ	JJ	_	8	amod	_	_
8	13	13	CD	CD	_	6	dobj	_	_
9	or	or	CC	CC	_	8	cc	_	_
10	141	141	CD	CD	_	11	nummod	_	_
11	aa	aa	NN	NN	_	8	conj	_	_
12	fail	fail	VBP	VBP	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	recruit	recruit	VB	VB	_	12	xcomp	_	_
15	IRAK	irak	NN	NN	_	14	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	consistent	consistent	JJ	JJ	_	15	acl:relcl	_	_
20	with	with	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	inability	inability	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	mutants	mutant	NNS	NNS	_	22	nmod	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	transmit	transmit	VB	VB	_	22	acl	_	_
28	LPS	lps	NN	NN	_	30	compound	_	_
29	cellular	cellular	JJ	JJ	_	30	amod	_	_
30	signaling	signaling	NN	NN	_	27	dobj	_	_
31	.	.	.	.	_	12	punct	_	_

1	Moreover	moreover	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	both	both	DT	DT	_	5	det	_	_
4	deletion	deletion	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	8	nsubj	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	still	still	RB	RB	_	8	advmod	_	_
8	form	form	VB	VB	_	0	root	_	_
9	complexes	complex	NNS	NNS	_	8	dobj	_	_
10	with	with	IN	IN	_	12	case	_	_
11	wild-type	wild-type	JJ	JJ	_	12	amod	_	_
12	TLR2	tlr2	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	act	act	VB	VB	_	8	conj	_	_
15	in	in	IN	IN	_	21	case	_	_
16	a	a	DT	DT	_	21	det	_	_
17	dominant-negative	dominant-negative	JJ	JJ	_	21	amod	_	_
18	(	(	-LRB-	-LRB-	_	21	punct	_	_
19	DN	dn	JJ	JJ	_	21	amod	_	_
20	)	)	-RRB-	-RRB-	_	21	punct	_	_
21	fashion	fashion	NN	NN	_	14	nmod	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	block	block	VB	VB	_	14	xcomp	_	_
24	TLR2-mediated	tlr2-mediated	JJ	JJ	_	26	amod	_	_
25	signal	signal	NN	NN	_	26	compound	_	_
26	transduction	transduction	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	8	punct	_	_

1	DN	dn	JJ	JJ	_	2	amod	_	_
2	constructs	construct	NNS	NNS	_	24	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	myeloid	myeloid	JJ	JJ	_	6	amod	_	_
5	differentiation	differentiation	NN	NN	_	6	compound	_	_
6	protein	protein	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	IRAK	irak	NN	NN	_	6	conj	_	_
9	,	,	,	,	_	6	punct	_	_
10	TNF	tnf	NN	NN	_	12	compound	_	_
11	receptor-associated	receptor-associated	JJ	JJ	_	12	amod	_	_
12	factor	factor	NN	NN	_	6	conj	_	_
13	6	6	CD	CD	_	12	nummod	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	NF-kappaB-inducing	nf-kappab-inducing	JJ	JJ	_	17	amod	_	_
17	kinase	kinase	NN	NN	_	6	conj	_	_
18	,	,	,	,	_	2	punct	_	_
19	when	when	WRB	WRB	_	20	advmod	_	_
20	coexpressed	coexpress	VBN	VBN	_	24	advcl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	TLR2	tlr2	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	20	punct	_	_
24	abrogate	abrogate	VBP	VBP	_	0	root	_	_
25	TLR2-mediated	tlr2-mediated	JJ	JJ	_	27	amod	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	27	compound	_	_
27	activation	activation	NN	NN	_	24	dobj	_	_
28	.	.	.	.	_	24	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	7	det	_	_
5	conserved	conserve	VBN	VBN	_	7	amod	_	_
6	signaling	signaling	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	3	dobj	_	_
8	for	for	IN	IN	_	9	case	_	_
9	TLR2	tlr2	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	IL-1Rs	il-1r	NNS	NNS	_	9	conj	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	suggest	suggest	VBP	VBP	_	3	conj	_	_
14	a	a	DT	DT	_	16	det	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	mechanism	mechanism	NN	NN	_	13	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	inhibition	inhibition	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	TLR2	tlr2	NN	NN	_	19	nmod	_	_
22	by	by	IN	IN	_	24	case	_	_
23	DN	dn	JJ	JJ	_	24	amod	_	_
24	variants	variant	NNS	NNS	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	Janus	janus	NN	NN	_	7	compound	_	_
5	kinase	kinase	NN	NN	_	7	compound	_	_
6	3-STAT5a	3-stat5a	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	1	nmod	_	_
8	after	after	IN	IN	_	10	case	_	_
9	CD40	cd40	NN	NN	_	10	compound	_	_
10	triggering	triggering	NN	NN	_	1	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
14	but	but	CC	CC	_	13	cc	_	_
15	not	not	RB	RB	_	19	neg	_	_
16	of	of	IN	IN	_	19	case	_	_
17	resting	rest	VBG	VBG	_	19	amod	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	13	conj	_	_
20	.	.	.	.	_	1	punct	_	_

1	CD40/CD40	cd40/cd40	NN	NN	_	3	compound	_	_
2	ligand	ligand	NN	NN	_	3	compound	_	_
3	interactions	interaction	NNS	NNS	_	4	nsubj	_	_
4	play	play	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	key	key	JJ	JJ	_	7	amod	_	_
7	role	role	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	immune	immune	JJ	JJ	_	11	amod	_	_
11	responses	response	NNS	NNS	_	4	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	monocytes	monocyte	NNS	NNS	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	dendritic	dendritic	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	14	conj	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	signal	signal	NN	NN	_	4	compound	_	_
3	transduction	transduction	NN	NN	_	4	compound	_	_
4	events	event	NNS	NNS	_	15	nsubjpass	_	_
5	triggered	trigger	VBN	VBN	_	4	acl	_	_
6	by	by	IN	IN	_	7	case	_	_
7	cross-linking	cross-linking	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	CD40	cd40	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	7	nmod	_	_
12	have	have	VBP	VBP	_	15	aux	_	_
13	been	be	VBN	VBN	_	15	auxpass	_	_
14	widely	widely	RB	RB	_	15	advmod	_	_
15	studied	study	VBN	VBN	_	0	root	_	_
16	in	in	IN	IN	_	19	case	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	15	nmod	_	_
20	,	,	,	,	_	15	punct	_	_
21	but	but	CC	CC	_	15	cc	_	_
22	little	little	JJ	JJ	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	known	know	VBN	VBN	_	15	conj	_	_
25	about	about	IN	IN	_	26	case	_	_
26	signaling	signaling	NN	NN	_	24	nmod	_	_
27	following	follow	VBG	VBG	_	29	case	_	_
28	CD40	cd40	NN	NN	_	29	compound	_	_
29	stimulation	stimulation	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	monocytes	monocyte	NNS	NNS	_	29	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	resting	rest	VBG	VBG	_	36	amod	_	_
34	tonsillar	tonsillar	JJ	JJ	_	36	amod	_	_
35	B	b	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	31	conj	_	_
37	.	.	.	.	_	15	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	CD40	cd40	NN	NN	_	7	compound	_	_
7	pathway	pathway	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	12	case	_	_
9	highly	highly	RB	RB	_	10	advmod	_	_
10	purified	purify	VBN	VBN	_	12	amod	_	_
11	human	human	JJ	JJ	_	12	amod	_	_
12	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	resting	rest	VBG	VBG	_	16	amod	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	12	conj	_	_
17	.	.	.	.	_	4	punct	_	_

1	After	after	IN	IN	_	3	case	_	_
2	CD40	cd40	NN	NN	_	3	compound	_	_
3	triggering	triggering	NN	NN	_	21	nmod	_	_
4	,	,	,	,	_	21	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	similar	similar	JJ	JJ	_	7	amod	_	_
7	activation	activation	NN	NN	_	21	nsubj	_	_
8	of	of	IN	IN	_	20	case	_	_
9	the	the	DT	DT	_	20	det	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
11	(	(	-LRB-	-LRB-	_	16	punct	_	_
12	but	but	CC	CC	_	16	cc	_	_
13	not	not	RB	RB	_	16	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	AP-1	ap-1	NN	NN	_	20	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	transcription	transcription	NN	NN	_	20	compound	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	complex	complex	NN	NN	_	7	nmod	_	_
21	occurred	occur	VBD	VBD	_	0	root	_	_
22	in	in	IN	IN	_	25	case	_	_
23	both	both	DT	DT	_	25	det	_	_
24	cell	cell	NN	NN	_	25	compound	_	_
25	preparations	preparation	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	21	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	components	component	NNS	NNS	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
8	complexes	complex	NNS	NNS	_	4	nmod	_	_
9	were	be	VBD	VBD	_	10	cop	_	_
10	different	different	JJ	JJ	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	monocytes	monocyte	NNS	NNS	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	conj	_	_
16	,	,	,	,	_	10	punct	_	_
17	because	because	IN	IN	_	20	mark	_	_
18	p50	p50	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	part	part	NN	NN	_	10	advcl	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	24	compound	_	_
24	complex	complex	NN	NN	_	20	nmod	_	_
25	induced	induce	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	CD40	cd40	NN	NN	_	28	compound	_	_
28	triggering	triggering	NN	NN	_	25	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	both	both	CC	CC	_	31	cc:preconj	_	_
31	monocytes	monocyte	NNS	NNS	_	25	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	B	b	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	conj	_	_
35	,	,	,	,	_	10	punct	_	_
36	whereas	whereas	IN	IN	_	10	dep	_	_
37	p65	p65	NN	NN	_	40	nsubjpass	_	_
38	was	be	VBD	VBD	_	40	auxpass	_	_
39	only	only	RB	RB	_	40	advmod	_	_
40	induced	induce	VBN	VBN	_	10	parataxis	_	_
41	in	in	IN	IN	_	43	case	_	_
42	B	b	NN	NN	_	43	compound	_	_
43	cells	cell	NNS	NNS	_	40	nmod	_	_
44	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	30	nmod	_	_
3	,	,	,	,	_	30	punct	_	_
4	although	although	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	Janus	janus	NN	NN	_	10	compound	_	_
7	kinase	kinase	NN	NN	_	10	compound	_	_
8	3	3	CD	CD	_	10	nummod	_	_
9	tyrosine	tyrosine	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	12	nsubjpass	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	associated	associate	VBN	VBN	_	30	advcl	_	_
13	with	with	IN	IN	_	15	case	_	_
14	CD40	cd40	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	both	both	CC	CC	_	18	cc:preconj	_	_
18	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	resting	rest	VBG	VBG	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	conj	_	_
23	,	,	,	,	_	30	punct	_	_
24	Janus	janus	NN	NN	_	28	compound	_	_
25	kinase	kinase	NN	NN	_	28	compound	_	_
26	3	3	CD	CD	_	28	nummod	_	_
27	phosphorylation	phosphorylation	NN	NN	_	28	compound	_	_
28	induction	induction	NN	NN	_	30	nsubjpass	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	observed	observe	VBN	VBN	_	0	root	_	_
31	only	only	RB	RB	_	30	advcl	_	_
32	in	in	IN	IN	_	34	case	_	_
33	CD40-activated	cd40-activated	JJ	JJ	_	34	amod	_	_
34	monocytes	monocyte	NNS	NNS	_	31	nmod	_	_
35	,	,	,	,	_	30	punct	_	_
36	with	with	IN	IN	_	38	case	_	_
37	subsequent	subsequent	JJ	JJ	_	38	amod	_	_
38	induction	induction	NN	NN	_	30	nmod	_	_
39	of	of	IN	IN	_	43	case	_	_
40	STAT5a	stat5a	NN	NN	_	43	compound	_	_
41	DNA	dna	NN	NN	_	43	compound	_	_
42	binding	binding	NN	NN	_	43	compound	_	_
43	activity	activity	NN	NN	_	38	nmod	_	_
44	in	in	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	nucleus	nucleus	NN	NN	_	38	nmod	_	_
47	.	.	.	.	_	30	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	activation	activation	NN	NN	_	7	compound	_	_
7	signals	signal	NNS	NNS	_	14	nsubj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	monocytes	monocyte	NNS	NNS	_	11	conj	_	_
14	differ	differ	VBP	VBP	_	3	ccomp	_	_
15	following	follow	VBG	VBG	_	17	case	_	_
16	CD40	cd40	NN	NN	_	17	compound	_	_
17	stimulation	stimulation	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	observation	observation	NN	NN	_	4	nsubj	_	_
3	is	be	VBZ	VBZ	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	detection	detection	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	normal	normal	JJ	JJ	_	12	amod	_	_
10	CD40-induced	cd40-induced	JJ	JJ	_	12	amod	_	_
11	monocyte	monocyte	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	patients	patient	NNS	NNS	_	7	nmod	_	_
15	with	with	IN	IN	_	20	case	_	_
16	CD40	cd40	NN	NN	_	20	compound	_	_
17	ligand+	ligand+	JJ	JJ	_	20	amod	_	_
18	hyper	hyper	NN	NN	_	20	compound	_	_
19	IgM	igm	NN	NN	_	20	compound	_	_
20	syndrome	syndrome	NN	NN	_	14	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	whom	whom	WP	WP	_	32	nmod	_	_
23	a	a	DT	DT	_	24	det	_	_
24	defect	defect	NN	NN	_	32	nsubjpass	_	_
25	in	in	IN	IN	_	29	case	_	_
26	CD40-induced	cd40-induced	JJ	JJ	_	29	amod	_	_
27	B	b	NN	NN	_	29	compound	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	activation	activation	NN	NN	_	24	nmod	_	_
30	has	have	VBZ	VBZ	_	32	aux	_	_
31	been	be	VBN	VBN	_	32	auxpass	_	_
32	reported	report	VBN	VBN	_	14	acl:relcl	_	_
33	.	.	.	.	_	4	punct	_	_

1	Clonality	clonality	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	X-chromosome	x-chromosome	NN	NN	_	5	compound	_	_
5	inactivation	inactivation	NN	NN	_	3	dobj	_	_
6	at	at	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	human	human	JJ	JJ	_	11	amod	_	_
9	androgen	androgen	NN	NN	_	11	compound	_	_
10	receptor	receptor	NN	NN	_	11	compound	_	_
11	gene	gene	NN	NN	_	3	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	Humara	humara	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	.	.	.	.	_	2	punct	_	_

1	Evaluation	evaluation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	large	large	JJ	JJ	_	4	amod	_	_
4	cohorts	cohort	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	patients	patient	NNS	NNS	_	4	nmod	_	_
7	with	with	IN	IN	_	10	case	_	_
8	chronic	chronic	JJ	JJ	_	10	amod	_	_
9	myeloproliferative	myeloproliferative	JJ	JJ	_	10	amod	_	_
10	diseases	disease	NNS	NNS	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	secondary	secondary	JJ	JJ	_	13	amod	_	_
13	neutrophilia	neutrophilia	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	reactive	reactive	JJ	JJ	_	17	amod	_	_
17	thrombocytosis	thrombocytosis	NN	NN	_	10	conj	_	_
18	.	.	.	.	_	1	punct	_	_

1	Chronic	chronic	JJ	JJ	_	3	amod	_	_
2	myeloproliferative	myeloproliferative	JJ	JJ	_	3	amod	_	_
3	diseases	disease	NNS	NNS	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	MPDs	mpd	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	are	be	VBP	VBP	_	9	auxpass	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	consistent	consistent	JJ	JJ	_	12	amod	_	_
12	cytogenetic	cytogenetic	JJ	JJ	_	9	nmod	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	molecular	molecular	JJ	JJ	_	12	conj	_	_
15	abnormalities	abnormality	NNS	NNS	_	12	dep	_	_
16	.	.	.	.	_	9	punct	_	_

1	Demonstration	demonstration	NN	NN	_	17	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	clonal	clonal	JJ	JJ	_	5	amod	_	_
4	cell	cell	NN	NN	_	5	compound	_	_
5	growth	growth	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	analysis	analysis	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	14	case	_	_
9	X-chromosome	x-chromosome	NN	NN	_	14	compound	_	_
10	inactivation	inactivation	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	XCI	xci	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	patterns	pattern	NNS	NNS	_	7	nmod	_	_
15	in	in	IN	IN	_	16	case	_	_
16	females	female	NNS	NNS	_	14	nmod	_	_
17	provides	provide	VBZ	VBZ	_	0	root	_	_
18	a	a	DT	DT	_	20	det	_	_
19	promising	promising	JJ	JJ	_	20	amod	_	_
20	tool	tool	NN	NN	_	17	dobj	_	_
21	for	for	IN	IN	_	22	case	_	_
22	diagnosis	diagnosis	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	17	punct	_	_

1	However	however	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	this	this	DT	DT	_	4	det	_	_
4	technique	technique	NN	NN	_	7	nsubjpass	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	complicated	complicate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	excessive	excessive	JJ	JJ	_	10	amod	_	_
10	lyonization	lyonization	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	normal	normal	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	mimicking	mimic	VBG	VBG	_	13	acl	_	_
15	clonal	clonal	JJ	JJ	_	17	amod	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	growth	growth	NN	NN	_	14	dobj	_	_
18	:	:	:	:	_	7	punct	_	_
19	We	we	PRP	PRP	_	20	nsubj	_	_
20	analyzed	analyze	VBD	VBD	_	7	parataxis	_	_
21	XCI	xci	NN	NN	_	22	compound	_	_
22	patterns	pattern	NNS	NNS	_	20	dobj	_	_
23	at	at	IN	IN	_	31	case	_	_
24	the	the	DT	DT	_	31	det	_	_
25	human	human	JJ	JJ	_	31	amod	_	_
26	androgen	androgen	NN	NN	_	31	compound	_	_
27	receptor	receptor	NN	NN	_	31	compound	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	HUMARA	humara	NN	NN	_	31	compound	_	_
30	)	)	-RRB-	-RRB-	_	31	punct	_	_
31	locus	locus	NN	NN	_	22	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	146	146	CD	CD	_	35	nummod	_	_
34	healthy	healthy	JJ	JJ	_	35	amod	_	_
35	females	female	NNS	NNS	_	31	nmod	_	_
36	,	,	,	,	_	35	punct	_	_
37	65	65	CD	CD	_	38	nummod	_	_
38	women	woman	NNS	NNS	_	35	conj	_	_
39	with	with	IN	IN	_	41	case	_	_
40	secondary	secondary	JJ	JJ	_	41	amod	_	_
41	neutrophilia	neutrophilia	NN	NN	_	38	nmod	_	_
42	,	,	,	,	_	35	punct	_	_
43	31	31	CD	CD	_	44	nummod	_	_
44	women	woman	NNS	NNS	_	35	conj	_	_
45	with	with	IN	IN	_	47	case	_	_
46	reactive	reactive	JJ	JJ	_	47	amod	_	_
47	thrombocytosis	thrombocytosis	NN	NN	_	44	nmod	_	_
48	,	,	,	,	_	35	punct	_	_
49	and	and	CC	CC	_	35	cc	_	_
50	86	86	CD	CD	_	51	nummod	_	_
51	women	woman	NNS	NNS	_	35	conj	_	_
52	with	with	IN	IN	_	54	case	_	_
53	chronic	chronic	JJ	JJ	_	54	amod	_	_
54	MPDs	mpd	NNS	NNS	_	51	nmod	_	_
55	.	.	.	.	_	7	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	skewed	skewed	JJ	JJ	_	4	amod	_	_
3	XCI	xci	NN	NN	_	4	compound	_	_
4	pattern	pattern	NN	NN	_	23	nsubjpass	_	_
5	with	with	IN	IN	_	10	case	_	_
6	greater	greater	JJR	JJR	_	8	advmod	_	_
7	than	than	IN	IN	_	8	advmod	_	_
8	75	75	CD	CD	_	10	nummod	_	_
9	%	%	NN	NN	_	10	compound	_	_
10	amplification	amplification	NN	NN	_	4	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	1	1	CD	CD	_	13	nummod	_	_
13	allele	allele	NN	NN	_	10	nmod	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	allele	allele	NN	NN	_	16	compound	_	_
16	ratio	ratio	NN	NN	_	18	nsubj	_	_
17	&gt;	&gt;	JJR	JJR	_	18	dep	_	_
18	3	3	CD	CD	_	13	dep	_	_
19	:	:	:	:	_	18	punct	_	_
20	1	1	CD	CD	_	18	dep	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	found	find	VBN	VBN	_	0	root	_	_
24	in	in	IN	IN	_	25	case	_	_
25	22	22	CD	CD	_	23	nmod	_	_
26	(	(	-LRB-	-LRB-	_	28	punct	_	_
27	9.1	9.1	CD	CD	_	28	nummod	_	_
28	%	%	NN	NN	_	25	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	of	of	IN	IN	_	33	case	_	_
31	242	242	CD	CD	_	33	nummod	_	_
32	control	control	JJ	JJ	_	33	amod	_	_
33	subjects	subject	NNS	NNS	_	25	nmod	_	_
34	.	.	.	.	_	23	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	incidence	incidence	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	skewing	skewing	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	8	cop	_	_
6	statistically	statistically	RB	RB	_	8	advmod	_	_
7	significantly	significantly	RB	RB	_	8	advmod	_	_
8	lower	lower	JJR	JJR	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	women	woman	NNS	NNS	_	8	nmod	_	_
11	younger	younger	JJR	JJR	_	10	amod	_	_
12	than	than	IN	IN	_	14	case	_	_
13	30	30	CD	CD	_	14	nummod	_	_
14	years	year	NNS	NNS	_	11	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	2/73	2/73	CD	CD	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	compared	compare	VBN	VBN	_	20	case	_	_
19	with	with	IN	IN	_	20	case	_	_
20	women	woman	NNS	NNS	_	8	advcl	_	_
21	older	older	JJR	JJR	_	20	amod	_	_
22	than	than	IN	IN	_	24	case	_	_
23	60	60	CD	CD	_	24	nummod	_	_
24	years	year	NNS	NNS	_	21	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	10/53	10/53	CD	CD	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	.	.	.	.	_	8	punct	_	_

1	Of	of	IN	IN	_	3	case	_	_
2	86	86	CD	CD	_	3	nummod	_	_
3	patients	patient	NNS	NNS	_	14	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	a	a	DT	DT	_	7	det	_	_
6	chronic	chronic	JJ	JJ	_	7	amod	_	_
7	MPD	mpd	NN	NN	_	3	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	71	71	CD	CD	_	14	nsubj	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	82	82	CD	CD	_	12	nummod	_	_
12	%	%	NN	NN	_	9	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	exhibited	exhibit	VBD	VBD	_	0	root	_	_
15	an	a	DT	DT	_	17	det	_	_
16	allele	allele	NN	NN	_	17	compound	_	_
17	ratio	ratio	NN	NN	_	14	dobj	_	_
18	greater	greater	JJR	JJR	_	17	amod	_	_
19	than	than	IN	IN	_	20	case	_	_
20	3	3	CD	CD	_	18	nmod	_	_
21	:	:	:	:	_	20	punct	_	_
22	1	1	CD	CD	_	20	dep	_	_
23	,	,	,	,	_	14	punct	_	_
24	whereas	whereas	IN	IN	_	14	dep	_	_
25	only	only	RB	RB	_	26	advmod	_	_
26	10	10	CD	CD	_	36	nsubj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	12	12	CD	CD	_	29	nummod	_	_
29	%	%	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	of	of	IN	IN	_	35	case	_	_
32	86	86	CD	CD	_	35	nummod	_	_
33	age-matched	age-matched	JJ	JJ	_	35	amod	_	_
34	control	control	JJ	JJ	_	35	amod	_	_
35	subjects	subject	NNS	NNS	_	26	nmod	_	_
36	showed	show	VBD	VBD	_	14	parataxis	_	_
37	a	a	DT	DT	_	40	det	_	_
38	skewed	skewed	JJ	JJ	_	40	amod	_	_
39	XCI	xci	NN	NN	_	40	compound	_	_
40	pattern	pattern	NN	NN	_	36	dobj	_	_
41	.	.	.	.	_	14	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	statistical	statistical	JJ	JJ	_	3	amod	_	_
3	evaluation	evaluation	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	data	datum	NNS	NNS	_	3	nmod	_	_
7	showed	show	VBD	VBD	_	32	advcl	_	_
8	a	a	DT	DT	_	10	det	_	_
9	significant	significant	JJ	JJ	_	10	amod	_	_
10	difference	difference	NN	NN	_	7	dobj	_	_
11	between	between	IN	IN	_	12	case	_	_
12	patients	patient	NNS	NNS	_	10	nmod	_	_
13	with	with	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	chronic	chronic	JJ	JJ	_	16	amod	_	_
16	MPD	mpd	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	control	control	JJ	JJ	_	19	amod	_	_
19	subjects	subject	NNS	NNS	_	12	conj	_	_
20	,	,	,	,	_	32	punct	_	_
21	proof	proof	NN	NN	_	32	nsubj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	clonality	clonality	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	30	case	_	_
25	individual	individual	NN	NN	_	30	amod	_	_
26	,	,	,	,	_	25	punct	_	_
27	especially	especially	RB	RB	_	28	advmod	_	_
28	elderly	elderly	JJ	JJ	_	25	dep	_	_
29	,	,	,	,	_	25	punct	_	_
30	patients	patient	NNS	NNS	_	21	nmod	_	_
31	is	be	VBZ	VBZ	_	32	cop	_	_
32	difficult	difficult	JJ	JJ	_	0	root	_	_
33	.	.	.	.	_	32	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	4	nsubj	_	_
4	cooperates	cooperate	VBZ	VBZ	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	dep	_	_
7	erythropoietin	erythropoietin	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	c-Kit	c-kit	NN	NN	_	8	conj	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	enhance	enhance	VB	VB	_	4	xcomp	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	sustain	sustain	VB	VB	_	12	conj	_	_
15	proliferation	proliferation	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	progenitors	progenitor	NNS	NNS	_	15	nmod	_	_
19	in	in	FW	FW	_	20	compound	_	_
20	vitro	vitro	FW	FW	_	12	advmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	Although	although	IN	IN	_	7	mark	_	_
2	erythropoietin	erythropoietin	NN	NN	_	7	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	Epo	epo	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	essential	essential	JJ	JJ	_	23	advcl	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	production	production	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	mature	mature	JJ	JJ	_	15	amod	_	_
13	red	red	JJ	JJ	_	15	amod	_	_
14	blood	blood	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	10	nmod	_	_
16	,	,	,	,	_	23	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	cooperation	cooperation	NN	NN	_	23	nsubjpass	_	_
19	with	with	IN	IN	_	21	case	_	_
20	other	other	JJ	JJ	_	21	amod	_	_
21	factors	factor	NNS	NNS	_	18	nmod	_	_
22	is	be	VBZ	VBZ	_	23	auxpass	_	_
23	required	require	VBN	VBN	_	0	root	_	_
24	for	for	IN	IN	_	27	case	_	_
25	a	a	DT	DT	_	27	det	_	_
26	proper	proper	JJ	JJ	_	27	amod	_	_
27	balance	balance	NN	NN	_	23	nmod	_	_
28	between	between	IN	IN	_	30	case	_	_
29	progenitor	progenitor	NN	NN	_	30	compound	_	_
30	proliferation	proliferation	NN	NN	_	27	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	differentiation	differentiation	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	23	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	avian	avian	JJ	JJ	_	4	amod	_	_
3	erythroid	erythroid	JJ	JJ	_	4	amod	_	_
4	progenitors	progenitor	NNS	NNS	_	8	nmod	_	_
5	,	,	,	,	_	8	punct	_	_
6	steroid	steroid	NN	NN	_	7	compound	_	_
7	hormones	hormone	NNS	NNS	_	8	nsubj	_	_
8	cooperate	cooperate	VBP	VBP	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
11	kinase	kinase	NN	NN	_	12	compound	_	_
12	receptors	receptor	NNS	NNS	_	8	nmod	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	induce	induce	VB	VB	_	8	xcomp	_	_
15	renewal	renewal	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	erythroid	erythroid	JJ	JJ	_	18	amod	_	_
18	progenitors	progenitor	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	examined	examine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	corticosteroids	corticosteroid	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	expansion	expansion	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	primary	primary	JJ	JJ	_	16	amod	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	erythroid	erythroid	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	11	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	liquid	liquid	JJ	JJ	_	19	amod	_	_
19	cultures	culture	NNS	NNS	_	2	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	colony	colony	NN	NN	_	22	compound	_	_
22	assays	assay	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	2	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	11	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	Dex	dex	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	,	,	,	,	_	1	punct	_	_
6	a	a	DT	DT	_	9	det	_	_
7	synthetic	synthetic	JJ	JJ	_	9	amod	_	_
8	glucocorticoid	glucocorticoid	NN	NN	_	9	compound	_	_
9	hormone	hormone	NN	NN	_	1	appos	_	_
10	,	,	,	,	_	1	punct	_	_
11	cooperated	cooperate	VBD	VBD	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	Epo	epo	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	stem	stem	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	factor	factor	NN	NN	_	13	conj	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	induce	induce	VB	VB	_	11	xcomp	_	_
20	erythroid	erythroid	JJ	JJ	_	21	amod	_	_
21	progenitors	progenitor	NNS	NNS	_	19	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	undergo	undergo	VB	VB	_	21	acl	_	_
24	15	15	CD	CD	_	26	compound	_	_
25	to	to	TO	TO	_	26	dep	_	_
26	22	22	CD	CD	_	28	nummod	_	_
27	cell	cell	NN	NN	_	28	compound	_	_
28	divisions	division	NNS	NNS	_	23	dobj	_	_
29	,	,	,	,	_	19	punct	_	_
30	corresponding	correspond	VBG	VBG	_	36	case	_	_
31	to	to	TO	TO	_	36	case	_	_
32	a	a	DT	DT	_	36	det	_	_
33	10(5)-	10(5)-	CD	CD	_	36	nummod	_	_
34	to	to	TO	TO	_	36	dep	_	_
35	10(6)-fold	10(6)-fold	JJ	JJ	_	36	amod	_	_
36	amplification	amplification	NN	NN	_	19	advcl	_	_
37	of	of	IN	IN	_	39	case	_	_
38	erythroid	erythroid	JJ	JJ	_	39	amod	_	_
39	cells	cell	NNS	NNS	_	36	nmod	_	_
40	.	.	.	.	_	11	punct	_	_

1	Dex	dex	NN	NN	_	2	nsubj	_	_
2	acted	act	VBD	VBD	_	0	root	_	_
3	directly	directly	RB	RB	_	2	advmod	_	_
4	on	on	IN	IN	_	6	case	_	_
5	erythroid	erythroid	JJ	JJ	_	6	amod	_	_
6	progenitors	progenitor	NNS	NNS	_	2	nmod	_	_
7	and	and	CC	CC	_	2	cc	_	_
8	maintained	maintain	VBD	VBD	_	2	conj	_	_
9	the	the	DT	DT	_	11	det	_	_
10	colony-forming	colony-forming	JJ	JJ	_	11	amod	_	_
11	capacity	capacity	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	progenitor	progenitor	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	expanded	expand	VBN	VBN	_	15	acl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	liquid	liquid	JJ	JJ	_	19	amod	_	_
19	cultures	culture	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	hormone	hormone	NN	NN	_	3	nsubj	_	_
3	delayed	delay	VBD	VBD	_	0	root	_	_
4	terminal	terminal	JJ	JJ	_	5	amod	_	_
5	differentiation	differentiation	NN	NN	_	3	dobj	_	_
6	into	into	IN	IN	_	7	case	_	_
7	erythrocytes	erythrocyte	NNS	NNS	_	5	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	which	which	WDT	WDT	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	assayed	assay	VBN	VBN	_	7	acl:relcl	_	_
12	by	by	IN	IN	_	13	case	_	_
13	morphology	morphology	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	hemoglobin	hemoglobin	NN	NN	_	16	compound	_	_
16	accumulation	accumulation	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	13	punct	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	the	the	DT	DT	_	20	det	_	_
20	expression	expression	NN	NN	_	13	conj	_	_
21	of	of	IN	IN	_	22	case	_	_
22	genes	gene	NNS	NNS	_	20	nmod	_	_
23	characteristic	characteristic	JJ	JJ	_	22	amod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	immature	immature	JJ	JJ	_	26	amod	_	_
26	cells	cell	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	Sustained	sustained	JJ	JJ	_	2	amod	_	_
2	proliferation	proliferation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	erythroid	erythroid	JJ	JJ	_	5	amod	_	_
5	progenitors	progenitor	NNS	NNS	_	2	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	0	root	_	_
9	equally	equally	RB	RB	_	10	advmod	_	_
10	well	well	RB	RB	_	8	advmod	_	_
11	from	from	IN	IN	_	15	case	_	_
12	purified	purify	VBN	VBN	_	15	amod	_	_
13	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
14	burst-forming	burst-forming	JJ	JJ	_	15	amod	_	_
15	units	unit	NNS	NNS	_	8	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	BFU-E	bfu-e	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	,	,	,	,	_	15	punct	_	_
20	from	from	IN	IN	_	23	case	_	_
21	CD34(+)	cd34(+)	JJ	JJ	_	23	amod	_	_
22	blast	blast	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	15	conj	_	_
24	,	,	,	,	_	15	punct	_	_
25	and	and	CC	CC	_	15	cc	_	_
26	from	from	IN	IN	_	28	case	_	_
27	bone	bone	NN	NN	_	28	compound	_	_
28	marrow	marrow	NN	NN	_	15	conj	_	_
29	depleted	deplete	VBN	VBN	_	28	acl	_	_
30	from	from	IN	IN	_	32	case	_	_
31	CD34(+)	cd34(+)	JJ	JJ	_	32	amod	_	_
32	cells	cell	NNS	NNS	_	29	nmod	_	_
33	.	.	.	.	_	8	punct	_	_

1	Escape	escape	NN	NN	_	11	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	human	human	JJ	JJ	_	4	amod	_	_
4	cytomegalovirus	cytomegalovirus	NN	NN	_	1	nmod	_	_
5	from	from	IN	IN	_	9	case	_	_
6	HLA-DR-restricted	hla-dr-restricted	JJ	JJ	_	9	amod	_	_
7	CD4(+)	cd4(+)	JJ	JJ	_	9	amod	_	_
8	T-cell	t-cell	NN	NN	_	9	compound	_	_
9	response	response	NN	NN	_	1	nmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	mediated	mediate	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	repression	repression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	20	case	_	_
15	gamma	gamma	NN	NN	_	20	compound	_	_
16	interferon-induced	interferon-induced	JJ	JJ	_	20	amod	_	_
17	class	class	NN	NN	_	20	compound	_	_
18	II	ii	CD	CD	_	20	nummod	_	_
19	transactivator	transactivator	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Human	human	JJ	JJ	_	2	amod	_	_
2	cytomegalovirus	cytomegalovirus	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	HCMV	hcmv	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	a	a	DT	DT	_	8	det	_	_
8	betaherpesvirus	betaherpesvirus	NN	NN	_	2	appos	_	_
9	,	,	,	,	_	2	punct	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	pathogen	pathogen	NN	NN	_	0	root	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	escapes	escape	VBZ	VBZ	_	12	acl:relcl	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	recognition	recognition	NN	NN	_	14	dobj	_	_
17	through	through	IN	IN	_	19	case	_	_
18	various	various	JJ	JJ	_	19	amod	_	_
19	mechanisms	mechanism	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	HCMV	hcmv	NN	NN	_	10	nsubj	_	_
9	down	down	RB	RB	_	10	advmod	_	_
10	regulates	regulate	VBZ	VBZ	_	6	ccomp	_	_
11	gamma	gamma	NN	NN	_	18	compound	_	_
12	interferon	interferon	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	IFN-gamma	ifn-gamma	NN	NN	_	18	compound	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	-induced	-induced	JJ	JJ	_	18	amod	_	_
17	HLA-DR	hla-dr	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	10	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	U373	u373	NN	NN	_	23	compound	_	_
21	MG	mg	NN	NN	_	23	compound	_	_
22	astrocytoma	astrocytoma	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	nmod	_	_
24	due	due	JJ	JJ	_	27	case	_	_
25	to	to	TO	TO	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	defect	defect	NN	NN	_	10	advcl	_	_
28	downstream	downstream	RB	RB	_	27	amod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	STAT1	stat1	NN	NN	_	31	compound	_	_
31	phosphorylation	phosphorylation	NN	NN	_	28	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	nuclear	nuclear	JJ	JJ	_	34	amod	_	_
34	translocation	translocation	NN	NN	_	31	conj	_	_
35	.	.	.	.	_	6	punct	_	_

1	Repression	repression	NN	NN	_	12	nsubjpass	_	_
2	of	of	IN	IN	_	10	case	_	_
3	class	class	NN	NN	_	10	compound	_	_
4	II	ii	CD	CD	_	10	nummod	_	_
5	transactivator	transactivator	NN	NN	_	10	compound	_	_
6	(	(	-LRB-	-LRB-	_	10	punct	_	_
7	CIITA	ciita	NN	NN	_	10	compound	_	_
8	)	)	-RRB-	-RRB-	_	10	punct	_	_
9	mRNA	mrna	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	1	nmod	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	detected	detect	VBN	VBN	_	0	root	_	_
13	within	within	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	first	first	JJ	JJ	_	16	amod	_	_
16	hours	hour	NNS	NNS	_	12	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	IFN-gamma-HCMV	ifn-gamma-hcmv	NN	NN	_	19	compound	_	_
19	coincubation	coincubation	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	12	cc	_	_
21	results	result	VBZ	VBZ	_	12	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	absence	absence	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	HLA-DR	hla-dr	NN	NN	_	27	compound	_	_
27	synthesis	synthesis	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	defect	defect	NN	NN	_	3	nsubj	_	_
3	leads	lead	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	absence	absence	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	presentation	presentation	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	14	case	_	_
10	the	the	DT	DT	_	14	det	_	_
11	major	major	JJ	JJ	_	14	amod	_	_
12	immediate-early	immediate-early	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	IE1	ie1	NN	NN	_	8	nmod	_	_
15	to	to	TO	TO	_	19	case	_	_
16	specific	specific	JJ	JJ	_	19	amod	_	_
17	CD4(+)	cd4(+)	JJ	JJ	_	19	amod	_	_
18	T-cell	t-cell	NN	NN	_	19	compound	_	_
19	clones	clone	NNS	NNS	_	8	nmod	_	_
20	when	when	WRB	WRB	_	31	advmod	_	_
21	U373	u373	NN	NN	_	23	compound	_	_
22	MG	mg	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	31	nsubjpass	_	_
24	,	,	,	,	_	23	punct	_	_
25	used	use	VBN	VBN	_	23	acl	_	_
26	as	as	IN	IN	_	28	case	_	_
27	antigen-presenting	antigen-presenting	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	23	punct	_	_
30	are	be	VBP	VBP	_	31	auxpass	_	_
31	treated	treat	VBN	VBN	_	3	ccomp	_	_
32	with	with	IN	IN	_	33	case	_	_
33	IFN-gamma	ifn-gamma	NN	NN	_	31	nmod	_	_
34	plus	plus	CC	CC	_	33	cc	_	_
35	HCMV	hcmv	NN	NN	_	33	conj	_	_
36	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	presentation	presentation	NN	NN	_	10	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	endogenously	endogenously	RB	RB	_	7	advmod	_	_
6	synthesized	synthesize	VBN	VBN	_	7	amod	_	_
7	IE1	ie1	NN	NN	_	3	nmod	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	restored	restore	VBN	VBN	_	0	root	_	_
11	when	when	WRB	WRB	_	16	advmod	_	_
12	U373	u373	NN	NN	_	14	compound	_	_
13	MG	mg	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	transfected	transfect	VBN	VBN	_	10	ccomp	_	_
17	with	with	IN	IN	_	18	case	_	_
18	CIITA	ciita	NN	NN	_	16	nmod	_	_
19	prior	prior	RB	RB	_	21	advmod	_	_
20	to	to	TO	TO	_	21	case	_	_
21	infection	infection	NN	NN	_	16	advcl	_	_
22	with	with	IN	IN	_	23	case	_	_
23	HCMV	hcmv	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	10	punct	_	_

1	Altogether	altogether	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	indicate	indicate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	defect	defect	NN	NN	_	12	nsubj	_	_
9	induced	induce	VBN	VBN	_	8	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	HCMV	hcmv	NN	NN	_	9	nmod	_	_
12	resides	reside	VBZ	VBZ	_	5	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IFN-gamma-responsive	ifn-gamma-responsive	JJ	JJ	_	19	amod	_	_
19	promoter	promoter	NN	NN	_	15	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	CIITA	ciita	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	demonstration	demonstration	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	a	a	DT	DT	_	9	det	_	_
8	viral	viral	JJ	JJ	_	9	amod	_	_
9	inhibition	inhibition	NN	NN	_	5	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	CIITA	ciita	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	5	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	4	compound	_	_
4	activation	activation	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	supernatant	supernatant	JJ	JJ	_	11	amod	_	_
11	fluid	fluid	NN	NN	_	1	nmod	_	_
12	from	from	IN	IN	_	16	case	_	_
13	human	human	JJ	JJ	_	16	amod	_	_
14	renal	renal	JJ	JJ	_	16	amod	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	carcinomas	carcinoma	NNS	NNS	_	11	nmod	_	_
17	.	.	.	.	_	1	punct	_	_

1	T	t	NN	NN	_	2	compound	_	_
2	lymphocytes	lymphocyte	NNS	NNS	_	12	nsubj	_	_
3	from	from	IN	IN	_	4	case	_	_
4	patients	patient	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	renal	renal	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	carcinoma	carcinoma	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	RCC	rcc	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	show	show	VBP	VBP	_	0	root	_	_
13	reduced	reduce	VBN	VBN	_	15	amod	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	function	function	NN	NN	_	12	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	impaired	impaired	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	15	conj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	transcription	transcription	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	22	appos	_	_
25	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	determined	determine	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	suppression	suppression	NN	NN	_	4	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	T	t	NN	NN	_	10	compound	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	RCC	rcc	NN	NN	_	13	compound	_	_
13	patient	patient	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	2	cc	_	_
15	determined	determine	VBD	VBD	_	2	conj	_	_
16	whether	whether	IN	IN	_	25	mark	_	_
17	supernatant	supernatant	JJ	JJ	_	18	amod	_	_
18	fluid	fluid	NN	NN	_	25	nsubj	_	_
19	from	from	IN	IN	_	21	case	_	_
20	RCC	rcc	NN	NN	_	21	compound	_	_
21	explants	explant	NNS	NNS	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RCC-S	rcc-s	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	induced	induce	VBD	VBD	_	15	ccomp	_	_
26	the	the	DT	DT	_	28	det	_	_
27	same	same	JJ	JJ	_	28	amod	_	_
28	phenotype	phenotype	NN	NN	_	25	dobj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	suppression	suppression	NN	NN	_	28	nmod	_	_
32	in	in	IN	IN	_	35	case	_	_
33	normal	normal	JJ	JJ	_	35	amod	_	_
34	T	t	NN	NN	_	35	compound	_	_
35	cells	cell	NNS	NNS	_	25	nmod	_	_
36	that	that	WDT	WDT	_	38	nsubjpass	_	_
37	is	be	VBZ	VBZ	_	38	auxpass	_	_
38	observed	observe	VBN	VBN	_	35	acl:relcl	_	_
39	in	in	RP	RP	_	42	dep	_	_
40	patient	patient	NN	NN	_	42	compound	_	_
41	T	t	NN	NN	_	42	compound	_	_
42	cells	cell	NNS	NNS	_	38	nmod	_	_
43	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	13	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	kappaB-binding	kappab-binding	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	2	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	RCC	rcc	NN	NN	_	11	compound	_	_
11	patient	patient	NN	NN	_	8	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	altered	alter	VBN	VBN	_	0	root	_	_
14	as	as	IN	IN	_	15	mark	_	_
15	compared	compare	VBN	VBN	_	13	advcl	_	_
16	to	to	TO	TO	_	17	case	_	_
17	that	that	DT	DT	_	15	nmod	_	_
18	seen	see	VBN	VBN	_	17	acl	_	_
19	in	in	IN	IN	_	21	case	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	obtained	obtain	VBN	VBN	_	21	acl	_	_
23	from	from	IN	IN	_	25	case	_	_
24	normal	normal	JJ	JJ	_	25	amod	_	_
25	volunteers	volunteer	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	some	some	DT	DT	_	3	det	_	_
3	patients	patient	NNS	NNS	_	11	nmod	_	_
4	,	,	,	,	_	11	punct	_	_
5	no	no	DT	DT	_	6	neg	_	_
6	activation	activation	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	RelA/NFkappaB1-binding	rela/nfkappab1-binding	JJ	JJ	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	cop	_	_
11	detectable	detectable	JJ	JJ	_	0	root	_	_
12	,	,	,	,	_	11	punct	_	_
13	while	while	IN	IN	_	20	mark	_	_
14	in	in	IN	IN	_	15	case	_	_
15	others	other	NNS	NNS	_	20	nmod	_	_
16	kappaB-binding	kappab-binding	JJ	JJ	_	17	amod	_	_
17	activity	activity	NN	NN	_	20	nsubjpass	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	modestly	modestly	RB	RB	_	20	advmod	_	_
20	induced	induce	VBN	VBN	_	11	advcl	_	_
21	but	but	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	23	det	_	_
23	duration	duration	NN	NN	_	25	nsubjpass	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	reduced	reduce	VBN	VBN	_	20	conj	_	_
26	.	.	.	.	_	11	punct	_	_

1	IkappaBalpha	ikappabalpha	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	degraded	degrade	VBN	VBN	_	0	root	_	_
4	normally	normally	RB	RB	_	3	advmod	_	_
5	following	follow	VBG	VBG	_	6	case	_	_
6	stimulation	stimulation	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	both	both	CC	CC	_	10	cc:preconj	_	_
9	normal	normal	JJ	JJ	_	10	amod	_	_
10	controls	control	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	from	from	IN	IN	_	16	case	_	_
15	RCC	rcc	NN	NN	_	16	compound	_	_
16	patients	patient	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	RCC-S	rcc-s	NNS	NNS	_	4	nsubj	_	_
2	did	do	VBD	VBD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	alter	alter	VB	VB	_	0	root	_	_
5	the	the	DT	DT	_	7	det	_	_
6	cytoplasmic	cytoplasmic	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	RelA	rela	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	NF-kappaB1	nf-kappab1	NN	NN	_	9	conj	_	_
12	but	but	CC	CC	_	4	cc	_	_
13	did	do	VBD	VBD	_	14	aux	_	_
14	suppress	suppress	VB	VB	_	4	conj	_	_
15	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	localization	localization	NN	NN	_	14	dobj	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	inhibited	inhibit	VBD	VBD	_	14	conj	_	_
20	the	the	DT	DT	_	21	det	_	_
21	activation	activation	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	25	case	_	_
23	RelA/NF-kappaB1	rela/nf-kappab1	NN	NN	_	25	compound	_	_
24	binding	binding	NN	NN	_	25	compound	_	_
25	complexes	complex	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	RCC-S	rcc-s	NNS	NNS	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	induce	induce	VB	VB	_	3	ccomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	normal	normal	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	the	the	DT	DT	_	14	det	_	_
13	same	same	JJ	JJ	_	14	amod	_	_
14	phenotype	phenotype	NN	NN	_	7	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	impaired	impaired	JJ	JJ	_	18	amod	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	detected	detect	VBN	VBN	_	18	acl:relcl	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	RCC	rcc	NN	NN	_	27	compound	_	_
27	patient	patient	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	suppression	suppression	NN	NN	_	10	nsubj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	RCC-S	rcc-s	NNS	NNS	_	6	nmod	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	contribute	contribute	VB	VB	_	3	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	immunosuppression	immunosuppression	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	host	host	NN	NN	_	16	compound	_	_
16	immunity	immunity	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Monoclonal	monoclonal	JJ	JJ	_	4	amod	_	_
2	anti-endothelial	anti-endothelial	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	antibodies	antibody	NNS	NNS	_	11	nsubj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	patient	patient	NN	NN	_	4	nmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	Takayasu	takayasu	NN	NN	_	10	compound	_	_
10	arteritis	arteritis	NN	NN	_	7	nmod	_	_
11	activate	activate	VBP	VBP	_	0	root	_	_
12	endothelial	endothelial	JJ	JJ	_	13	amod	_	_
13	cells	cell	NNS	NNS	_	11	dobj	_	_
14	from	from	IN	IN	_	16	case	_	_
15	large	large	JJ	JJ	_	16	amod	_	_
16	vessels	vessel	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	To	to	TO	TO	_	4	mark	_	_
4	create	create	VB	VB	_	1	dep	_	_
5	monoclonal	monoclonal	JJ	JJ	_	8	amod	_	_
6	anti-endothelial	anti-endothelial	JJ	JJ	_	8	amod	_	_
7	cell	cell	NN	NN	_	8	compound	_	_
8	antibodies	antibody	NNS	NNS	_	4	dobj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	mAECA	maeca	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	from	from	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	patient	patient	NN	NN	_	8	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	Takayasu	takayasu	NN	NN	_	17	compound	_	_
17	arteritis	arteritis	NN	NN	_	14	nmod	_	_
18	to	to	TO	TO	_	19	mark	_	_
19	evaluate	evaluate	VB	VB	_	4	advcl	_	_
20	their	they	PRP$	PRP$	_	21	nmod:poss	_	_
21	ability	ability	NN	NN	_	19	dobj	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	activate	activate	VB	VB	_	21	acl	_	_
24	human	human	JJ	JJ	_	28	amod	_	_
25	umbilical	umbilical	JJ	JJ	_	28	amod	_	_
26	vein	vein	NN	NN	_	28	compound	_	_
27	endothelial	endothelial	JJ	JJ	_	28	amod	_	_
28	cells	cell	NNS	NNS	_	23	dobj	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	HUVEC	huvec	NNS	NNS	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	,	,	,	,	_	4	punct	_	_
33	and	and	CC	CC	_	4	cc	_	_
34	to	to	TO	TO	_	35	mark	_	_
35	characterize	characterize	VB	VB	_	4	conj	_	_
36	the	the	DT	DT	_	37	det	_	_
37	mechanism	mechanism	NN	NN	_	35	dobj	_	_
38	of	of	IN	IN	_	40	case	_	_
39	EC	ec	NN	NN	_	40	compound	_	_
40	activation	activation	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	1	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	A	a	DT	DT	_	4	det	_	_
4	panel	panel	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	mAECA	maeca	NNS	NNS	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	generated	generate	VBN	VBN	_	1	dep	_	_
9	from	from	IN	IN	_	12	case	_	_
10	peripheral	peripheral	JJ	JJ	_	12	amod	_	_
11	blood	blood	NN	NN	_	12	compound	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	patient	patient	NN	NN	_	12	nmod	_	_
16	with	with	IN	IN	_	18	case	_	_
17	Takayasu	takayasu	NN	NN	_	18	compound	_	_
18	arteritis	arteritis	NN	NN	_	15	nmod	_	_
19	,	,	,	,	_	8	punct	_	_
20	using	use	VBG	VBG	_	8	xcomp	_	_
21	Epstein-Barr	epstein-barr	JJ	JJ	_	23	amod	_	_
22	virus	virus	NN	NN	_	23	compound	_	_
23	transformation	transformation	NN	NN	_	20	dobj	_	_
24	.	.	.	.	_	1	punct	_	_

1	Activity	activity	NN	NN	_	22	nsubjpass	_	_
2	against	against	IN	IN	_	4	case	_	_
3	macrovascular	macrovascular	JJ	JJ	_	4	amod	_	_
4	EC	ec	NN	NN	_	1	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	HUVEC	huvec	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	microvascular	microvascular	JJ	JJ	_	20	amod	_	_
10	EC	ec	NN	NN	_	20	compound	_	_
11	(	(	-LRB-	-LRB-	_	20	punct	_	_
12	human	human	JJ	JJ	_	20	amod	_	_
13	bone	bone	NN	NN	_	20	compound	_	_
14	marrow	marrow	NN	NN	_	20	compound	_	_
15	EC	ec	NN	NN	_	20	compound	_	_
16	immortalized	immortalize	VBN	VBN	_	20	amod	_	_
17	by	by	IN	IN	_	20	amod	_	_
18	SV40	sv40	NN	NN	_	20	compound	_	_
19	)	)	-RRB-	-RRB-	_	20	punct	_	_
20	antigens	antigen	NNS	NNS	_	4	conj	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	detected	detect	VBN	VBN	_	0	root	_	_
23	by	by	IN	IN	_	26	case	_	_
24	enzyme-linked	enzyme-linked	JJ	JJ	_	26	amod	_	_
25	immunosorbent	immunosorbent	JJ	JJ	_	26	amod	_	_
26	assay	assay	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	22	punct	_	_

1	Inhibition	inhibition	NN	NN	_	2	compound	_	_
2	studies	study	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	used	use	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	select	select	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	monoclonal	monoclonal	JJ	JJ	_	9	amod	_	_
9	antibodies	antibody	NNS	NNS	_	6	dobj	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	mAECA	maeca	NNS	NNS	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	which	which	WDT	WDT	_	14	nsubj	_	_
14	share	share	VBP	VBP	_	9	acl:relcl	_	_
15	the	the	DT	DT	_	20	det	_	_
16	same	same	JJ	JJ	_	20	amod	_	_
17	EC	ec	NN	NN	_	20	compound	_	_
18	epitope	epitope	NN	NN	_	20	compound	_	_
19	binding	binding	NN	NN	_	20	compound	_	_
20	specificity	specificity	NN	NN	_	14	dobj	_	_
21	as	as	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	total	total	JJ	JJ	_	24	amod	_	_
24	IgG-AECA	igg-aeca	NN	NN	_	20	nmod	_	_
25	from	from	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	Takayasu	takayasu	NN	NN	_	29	compound	_	_
28	arteritis	arteritis	NN	NN	_	29	compound	_	_
29	patient	patient	NN	NN	_	14	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	binding	binding	NN	NN	_	11	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	det	_	_
5	mAECA	maeca	NNS	NNS	_	2	nmod	_	_
6	to	to	TO	TO	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	aortic	aortic	JJ	JJ	_	9	amod	_	_
9	EC	ec	NN	NN	_	2	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	studied	study	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	13	case	_	_
13	immunohistochemistry	immunohistochemistry	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	secretion	secretion	NN	NN	_	3	compound	_	_
3	levels	level	NNS	NNS	_	17	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	interleukin-6	interleukin-6	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	IL-6	il-6	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	von	von	NN	NN	_	12	compound	_	_
11	Willebrand	willebrand	NN	NN	_	12	compound	_	_
12	factor	factor	NN	NN	_	5	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	vWF	vwf	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	were	be	VBD	VBD	_	17	auxpass	_	_
17	determined	determine	VBN	VBN	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	serve	serve	VB	VB	_	17	xcomp	_	_
21	as	as	IN	IN	_	22	case	_	_
22	markers	marker	NNS	NNS	_	20	nmod	_	_
23	for	for	IN	IN	_	25	case	_	_
24	EC	ec	NN	NN	_	25	compound	_	_
25	activation	activation	NN	NN	_	22	nmod	_	_
26	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	activated	activate	VBN	VBN	_	3	amod	_	_
3	EC	ec	NN	NN	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	examined	examine	VBN	VBN	_	0	root	_	_
6	for	for	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	adherence	adherence	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	line	line	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	U937	u937	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	8	punct	_	_
18	as	as	RB	RB	_	8	cc	_	_
19	well	well	RB	RB	_	18	mwe	_	_
20	as	as	IN	IN	_	18	mwe	_	_
21	for	for	IN	IN	_	22	case	_	_
22	expression	expression	NN	NN	_	8	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	vascular	vascular	JJ	JJ	_	27	amod	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	adhesion	adhesion	NN	NN	_	27	compound	_	_
27	molecule	molecule	NN	NN	_	22	nmod	_	_
28	1	1	CD	CD	_	27	nummod	_	_
29	,	,	,	,	_	27	punct	_	_
30	intercellular	intercellular	JJ	JJ	_	32	amod	_	_
31	adhesion	adhesion	NN	NN	_	32	compound	_	_
32	molecule	molecule	NN	NN	_	27	conj	_	_
33	1	1	CD	CD	_	32	nummod	_	_
34	,	,	,	,	_	27	punct	_	_
35	and	and	CC	CC	_	27	cc	_	_
36	E-selectin	e-selectin	NN	NN	_	27	conj	_	_
37	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	11	nmod	_	_
3	,	,	,	,	_	11	punct	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	11	nsubjpass	_	_
6	of	of	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	mAECA-treated	maeca-treated	JJ	JJ	_	9	amod	_	_
9	EC	ec	NN	NN	_	5	nmod	_	_
10	were	be	VBD	VBD	_	11	auxpass	_	_
11	analyzed	analyze	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	induction	induction	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	translocation	translocation	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	nuclear	nuclear	JJ	JJ	_	20	amod	_	_
19	factor	factor	NN	NN	_	20	compound	_	_
20	kappaB	kappab	NN	NN	_	16	nmod	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	NF-kappaB	nf-kappab	NN	NN	_	20	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	,	,	,	,	_	11	punct	_	_
25	using	use	VBG	VBG	_	11	xcomp	_	_
26	a	a	DT	DT	_	29	det	_	_
27	specific	specific	JJ	JJ	_	29	amod	_	_
28	NF-kappaB	nf-kappab	NN	NN	_	29	compound	_	_
29	oligoprobe	oligoprobe	NN	NN	_	25	dobj	_	_
30	in	in	IN	IN	_	35	case	_	_
31	an	a	DT	DT	_	35	det	_	_
32	electrophoretic	electrophoretic	JJ	JJ	_	35	amod	_	_
33	mobility	mobility	NN	NN	_	35	compound	_	_
34	shift	shift	NN	NN	_	35	compound	_	_
35	assay	assay	NN	NN	_	29	nmod	_	_
36	.	.	.	.	_	11	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Six	six	CD	CD	_	4	nummod	_	_
4	mAECA	maeca	NNS	NNS	_	6	nsubjpass	_	_
5	were	be	VBD	VBD	_	6	auxpass	_	_
6	selected	select	VBN	VBN	_	1	dep	_	_
7	,	,	,	,	_	6	punct	_	_
8	the	the	DT	DT	_	9	det	_	_
9	mixture	mixture	NN	NN	_	12	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	which	which	WDT	WDT	_	9	nmod	_	_
12	produced	produce	VBD	VBD	_	6	ccomp	_	_
13	100	100	CD	CD	_	15	nummod	_	_
14	%	%	NN	NN	_	15	compound	_	_
15	inhibition	inhibition	NN	NN	_	12	dobj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	binding	binding	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	original	original	JJ	JJ	_	21	amod	_	_
21	IgG	igg	NN	NN	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	from	from	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	det	_	_
25	patient	patient	NN	NN	_	21	nmod	_	_
26	with	with	IN	IN	_	28	case	_	_
27	Takayasu	takayasu	NN	NN	_	28	compound	_	_
28	arteritis	arteritis	NN	NN	_	25	nmod	_	_
29	)	)	-RRB-	-RRB-	_	25	punct	_	_
30	to	to	TO	TO	_	31	case	_	_
31	HUVEC	huvec	NNS	NNS	_	17	nmod	_	_
32	.	.	.	.	_	1	punct	_	_

1	All	all	DT	DT	_	2	det	_	_
2	mAECA	maeca	NNS	NNS	_	3	nsubj	_	_
3	possessed	possess	VBD	VBD	_	0	root	_	_
4	high	high	JJ	JJ	_	5	amod	_	_
5	activity	activity	NN	NN	_	3	dobj	_	_
6	against	against	IN	IN	_	8	case	_	_
7	macrovascular	macrovascular	JJ	JJ	_	8	amod	_	_
8	EC	ec	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	3	punct	_	_
10	but	but	CC	CC	_	3	cc	_	_
11	none	none	NN	NN	_	12	nsubj	_	_
12	had	have	VBD	VBD	_	3	conj	_	_
13	significant	significant	JJ	JJ	_	16	amod	_	_
14	antimicrovascular	antimicrovascular	JJ	JJ	_	16	amod	_	_
15	EC	ec	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	dobj	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	dep	_	_
2	mAECA	maeca	NNS	NNS	_	10	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	but	but	CC	CC	_	2	cc	_	_
5	not	not	RB	RB	_	8	neg	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	IgG	igg	NN	NN	_	2	conj	_	_
9	,	,	,	,	_	2	punct	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	anti-human	anti-human	JJ	JJ	_	14	amod	_	_
12	aortic	aortic	JJ	JJ	_	14	amod	_	_
13	EC	ec	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	10	punct	_	_

1	Four	four	CD	CD	_	9	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	6	6	CD	CD	_	7	nummod	_	_
5	mAECA	maeca	NNS	NNS	_	7	compound	_	_
6	activated	activate	VBD	VBD	_	7	amod	_	_
7	EC	ec	NN	NN	_	1	nmod	_	_
8	,	,	,	,	_	1	punct	_	_
9	manifested	manifest	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	increased	increase	VBN	VBN	_	12	amod	_	_
12	IL-6	il-6	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	vWF	vwf	NN	NN	_	12	conj	_	_
15	secretion	secretion	NN	NN	_	12	dep	_	_
16	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	4	4	CD	CD	_	3	nummod	_	_
3	mAECA	maeca	NNS	NNS	_	4	nsubj	_	_
4	induced	induce	VBD	VBD	_	0	root	_	_
5	EC	ec	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	adhesion	adhesion	NN	NN	_	9	compound	_	_
9	molecules	molecule	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	4	cc	_	_
11	increased	increase	VBD	VBD	_	4	conj	_	_
12	adhesion	adhesion	NN	NN	_	11	dobj	_	_
13	of	of	IN	IN	_	16	case	_	_
14	U937	u937	NN	NN	_	16	compound	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	12	nmod	_	_
17	to	to	TO	TO	_	18	case	_	_
18	EC	ec	NN	NN	_	12	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	mAECA	maeca	NNS	NNS	_	6	nsubj	_	_
6	stimulated	stimulate	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	nuclear	nuclear	JJ	JJ	_	9	amod	_	_
9	translocation	translocation	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
13	transcription	transcription	NN	NN	_	14	compound	_	_
14	factor	factor	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	CONCLUSION	conclusion	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	1	dep	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	AECA	aeca	NNS	NNS	_	10	nsubj	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	directly	directly	RB	RB	_	10	advmod	_	_
10	stimulate	stimulate	VB	VB	_	5	ccomp	_	_
11	EC	ec	NN	NN	_	10	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	Takayasu	takayasu	NN	NN	_	14	compound	_	_
14	arteritis	arteritis	NN	NN	_	11	nmod	_	_
15	through	through	IN	IN	_	16	case	_	_
16	elevation	elevation	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	adhesion	adhesion	NN	NN	_	20	compound	_	_
19	molecule	molecule	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	16	nmod	_	_
21	associated	associate	VBN	VBN	_	20	acl	_	_
22	with	with	IN	IN	_	24	case	_	_
23	NF-kappaB	nf-kappab	NN	NN	_	24	compound	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	adhesion	adhesion	NN	NN	_	24	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	monocytes	monocyte	NNS	NNS	_	26	nmod	_	_
29	,	,	,	,	_	10	punct	_	_
30	and	and	CC	CC	_	10	cc	_	_
31	may	may	MD	MD	_	33	aux	_	_
32	therefore	therefore	RB	RB	_	33	advmod	_	_
33	play	play	VB	VB	_	10	conj	_	_
34	a	a	DT	DT	_	36	det	_	_
35	pathogenic	pathogenic	JJ	JJ	_	36	amod	_	_
36	role	role	NN	NN	_	33	dobj	_	_
37	in	in	IN	IN	_	39	case	_	_
38	the	the	DT	DT	_	39	det	_	_
39	development	development	NN	NN	_	33	nmod	_	_
40	of	of	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	vasculopathy	vasculopathy	NN	NN	_	39	nmod	_	_
43	in	in	IN	IN	_	45	case	_	_
44	Takayasu	takayasu	NN	NN	_	45	compound	_	_
45	arteritis	arteritis	NN	NN	_	42	nmod	_	_
46	.	.	.	.	_	1	punct	_	_

1	ICSAT	icsat	NN	NN	_	2	compound	_	_
2	overexpression	overexpression	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	sufficient	sufficient	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	cause	cause	VB	VB	_	5	xcomp	_	_
8	adult	adult	JJ	JJ	_	10	amod	_	_
9	T-cell	t-cell	NN	NN	_	10	compound	_	_
10	leukemia	leukemia	NN	NN	_	7	dobj	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	multiple	multiple	JJ	JJ	_	13	amod	_	_
13	myeloma	myeloma	NN	NN	_	10	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	ICSAT	icsat	NN	NN	_	16	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	11	punct	_	_
3	Interferon	interferon	NN	NN	_	11	compound	_	_
4	Consensus	consensus	NN	NN	_	11	compound	_	_
5	Sequence	sequence	NN	NN	_	11	compound	_	_
6	binding	binding	NN	NN	_	11	compound	_	_
7	protein	protein	NN	NN	_	11	compound	_	_
8	for	for	IN	IN	_	11	amod	_	_
9	Activated	activate	VBN	VBN	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	1	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	16	amod	_	_
16	member	member	NN	NN	_	0	root	_	_
17	of	of	IN	IN	_	25	case	_	_
18	the	the	DT	DT	_	25	det	_	_
19	interferon	interferon	NN	NN	_	25	compound	_	_
20	regulatory	regulatory	JJ	JJ	_	25	amod	_	_
21	factor	factor	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	25	punct	_	_
23	IRF	irf	NN	NN	_	25	compound	_	_
24	)	)	-RRB-	-RRB-	_	25	punct	_	_
25	family	family	NN	NN	_	16	nmod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	originally	originally	RB	RB	_	31	advmod	_	_
31	identified	identify	VBN	VBN	_	28	acl	_	_
32	through	through	IN	IN	_	34	case	_	_
33	Southwestern	southwestern	NN	NN	_	34	compound	_	_
34	screening	screening	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	45	case	_	_
36	the	the	DT	DT	_	45	det	_	_
37	ATL	atl	NN	NN	_	45	compound	_	_
38	(	(	-LRB-	-LRB-	_	45	punct	_	_
39	Adult	adult	NN	NN	_	45	compound	_	_
40	T-cell	t-cell	NN	NN	_	45	compound	_	_
41	leukemia	leukemia	NN	NN	_	45	compound	_	_
42	)	)	-RRB-	-RRB-	_	45	punct	_	_
43	-16T	-16t	JJ	JJ	_	45	amod	_	_
44	expression	expression	NN	NN	_	45	compound	_	_
45	library	library	NN	NN	_	34	nmod	_	_
46	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	created	create	VBD	VBD	_	0	root	_	_
7	transgenic	transgenic	JJ	JJ	_	8	amod	_	_
8	mice	mouse	NNS	NNS	_	6	dobj	_	_
9	overexpressing	overexpress	VBG	VBG	_	8	acl	_	_
10	ICSAT	icsat	NN	NN	_	9	dobj	_	_
11	in	in	IN	IN	_	12	case	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	6	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	spontaneous	spontaneous	JJ	JJ	_	3	amod	_	_
3	tumorigenesis	tumorigenesis	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	observed	observe	VBN	VBN	_	16	advcl	_	_
7	,	,	,	,	_	16	punct	_	_
8	IL-2	il-2	NN	NN	_	9	compound	_	_
9	production	production	NN	NN	_	16	nsubjpass	_	_
10	with	with	IN	IN	_	13	case	_	_
11	Concanavalin	concanavalin	NN	NN	_	13	compound	_	_
12	A	a	NN	NN	_	13	compound	_	_
13	stimulation	stimulation	NN	NN	_	9	nmod	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	increased	increase	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	16	dep	_	_
18	transgenic	transgenic	JJ	JJ	_	16	dep	_	_
19	mice	mouse	NNS	NNS	_	16	dep	_	_
20	overexpressing	overexpress	VBG	VBG	_	16	dep	_	_
21	ICSAT	icsat	NN	NN	_	16	dep	_	_
22	.	.	.	.	_	16	punct	_	_

1	ICSAT	icsat	NN	NN	_	2	compound	_	_
2	overexpression	overexpression	NN	NN	_	5	nsubj	_	_
3	in	in	IN	IN	_	4	case	_	_
4	lymphocytes	lymphocyte	NNS	NNS	_	2	nmod	_	_
5	seems	seem	VBZ	VBZ	_	0	root	_	_
6	insufficient	insufficient	JJ	JJ	_	5	xcomp	_	_
7	for	for	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	leukemogenesis	leukemogenesis	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	ATL	atl	NN	NN	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	multiple	multiple	JJ	JJ	_	14	amod	_	_
14	myeloma	myeloma	NN	NN	_	11	conj	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	MM	mm	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	5	punct	_	_
19	however	however	RB	RB	_	31	advmod	_	_
20	,	,	,	,	_	31	punct	_	_
21	it	it	PRP	PRP	_	23	nsubj	_	_
22	may	may	MD	MD	_	23	aux	_	_
23	regulate	regulate	VB	VB	_	31	dep	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	activation	activation	NN	NN	_	23	dobj	_	_
27	and	and	CC	CC	_	31	cc	_	_
28	its	its	PRP$	PRP$	_	29	nmod:poss	_	_
29	overexpression	overexpression	NN	NN	_	31	conj	_	_
30	may	may	MD	MD	_	31	aux	_	_
31	lead	lead	VB	VB	_	5	parataxis	_	_
32	to	to	TO	TO	_	33	case	_	_
33	leukemogenesis	leukemogenesis	NN	NN	_	31	nmod	_	_
34	via	via	IN	IN	_	35	mark	_	_
35	controlling	control	VBG	VBG	_	31	advcl	_	_
36	IL-2	il-2	NN	NN	_	37	compound	_	_
37	production	production	NN	NN	_	35	dobj	_	_
38	.	.	.	.	_	5	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Clonality	clonality	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	granulocytes	granulocyte	NNS	NNS	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	conj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	healthy	healthy	JJ	JJ	_	10	amod	_	_
10	females	female	NNS	NNS	_	4	nmod	_	_
11	by	by	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	PCR-based	pcr-based	JJ	JJ	_	15	amod	_	_
14	HUMARA	humara	NN	NN	_	15	compound	_	_
15	method	method	NN	NN	_	2	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Clonality	clonality	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	8	nsubjpass	_	_
3	utilizing	utilize	VBG	VBG	_	2	acl	_	_
4	X-chromosome	x-chromosome	NN	NN	_	5	compound	_	_
5	inactivation	inactivation	NN	NN	_	3	dobj	_	_
6	has	have	VBZ	VBZ	_	8	aux	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	study	study	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	various	various	JJ	JJ	_	14	amod	_	_
14	diseases	disease	NNS	NNS	_	11	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	18	case	_	_
17	hematological	hematological	JJ	JJ	_	18	amod	_	_
18	malignancies	malignancy	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	9	det	_	_
2	human	human	JJ	JJ	_	9	amod	_	_
3	androgen	androgen	NN	NN	_	9	compound	_	_
4	receptor	receptor	NN	NN	_	9	compound	_	_
5	gene	gene	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	HUMARA	humara	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	assay	assay	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	the	the	DT	DT	_	12	det	_	_
12	newest	newest	JJS	JJS	_	0	root	_	_
13	of	of	IN	IN	_	15	case	_	_
14	such	such	JJ	JJ	_	15	amod	_	_
15	methods	method	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	12	punct	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	majority	majority	NN	NN	_	26	nsubjpass	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	female	female	JJ	JJ	_	23	amod	_	_
23	population	population	NN	NN	_	19	nmod	_	_
24	can	can	MD	MD	_	26	aux	_	_
25	be	be	VB	VB	_	26	auxpass	_	_
26	assessed	assess	VBN	VBN	_	12	conj	_	_
27	by	by	IN	IN	_	31	case	_	_
28	this	this	DT	DT	_	31	det	_	_
29	relatively	relatively	RB	RB	_	30	advmod	_	_
30	simple	simple	JJ	JJ	_	31	amod	_	_
31	procedure	procedure	NN	NN	_	26	nmod	_	_
32	.	.	.	.	_	12	punct	_	_

1	One	one	CD	CD	_	2	nummod	_	_
2	problem	problem	NN	NN	_	12	nsubj	_	_
3	in	in	IN	IN	_	4	mark	_	_
4	using	use	VBG	VBG	_	2	acl	_	_
5	these	these	DT	DT	_	8	det	_	_
6	clonality	clonality	NN	NN	_	8	compound	_	_
7	analysis	analysis	NN	NN	_	8	compound	_	_
8	methods	method	NNS	NNS	_	4	dobj	_	_
9	,	,	,	,	_	12	punct	_	_
10	however	however	RB	RB	_	12	advmod	_	_
11	,	,	,	,	_	12	punct	_	_
12	is	be	VBZ	VBZ	_	0	root	_	_
13	that	that	IN	IN	_	18	mark	_	_
14	there	there	EX	EX	_	18	expl	_	_
15	may	may	MD	MD	_	18	aux	_	_
16	be	be	VB	VB	_	18	cop	_	_
17	significant	significant	JJ	JJ	_	18	amod	_	_
18	variation	variation	NN	NN	_	12	ccomp	_	_
19	in	in	IN	IN	_	20	case	_	_
20	Lyonization	lyonization	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	23	case	_	_
22	blood	blood	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	20	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	normal	normal	JJ	JJ	_	26	amod	_	_
26	individuals	individual	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	12	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	26	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	diversity	diversity	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	X-chromosome	x-chromosome	NN	NN	_	8	compound	_	_
7	methylation	methylation	NN	NN	_	8	compound	_	_
8	patterns	pattern	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	reflect	reflect	VBP	VBP	_	8	acl:relcl	_	_
12	Lyonization	lyonization	NN	NN	_	11	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	assessed	assess	VBN	VBN	_	12	acl	_	_
15	by	by	IN	IN	_	14	dep	_	_
16	the	the	DT	DT	_	18	det	_	_
17	HUMARA	humara	NN	NN	_	18	compound	_	_
18	assay	assay	NN	NN	_	14	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	supposedly	supposedly	RB	RB	_	22	advmod	_	_
22	normal	normal	JJ	JJ	_	23	amod	_	_
23	population	population	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	analyzed	analyze	VBD	VBD	_	0	root	_	_
27	granulocytes	granulocyte	NNS	NNS	_	26	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	27	conj	_	_
31	from	from	IN	IN	_	42	case	_	_
32	97	97	CD	CD	_	42	nummod	_	_
33	relatively	relatively	RB	RB	_	34	advmod	_	_
34	young	young	JJ	JJ	_	42	amod	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	18-	18-	CD	CD	_	34	dep	_	_
37	to	to	TO	TO	_	36	dep	_	_
38	35-year-old	35-year-old	JJ	JJ	_	36	dep	_	_
39	)	)	-RRB-	-RRB-	_	36	punct	_	_
40	healthy	healthy	JJ	JJ	_	42	amod	_	_
41	female	female	JJ	JJ	_	42	amod	_	_
42	volunteers	volunteer	NNS	NNS	_	27	nmod	_	_
43	.	.	.	.	_	26	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	found	find	VBD	VBD	_	0	root	_	_
3	that	that	IN	IN	_	13	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	methylation	methylation	NN	NN	_	6	compound	_	_
6	patterns	pattern	NNS	NNS	_	13	nsubjpass	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	two	two	CD	CD	_	11	nummod	_	_
10	HUMARA	humara	NN	NN	_	11	compound	_	_
11	alleles	allele	NNS	NNS	_	6	nmod	_	_
12	were	be	VBD	VBD	_	13	auxpass	_	_
13	distributed	distribute	VBN	VBN	_	2	ccomp	_	_
14	even	even	RB	RB	_	15	advmod	_	_
15	more	more	RBR	RBR	_	16	dep	_	_
16	widely	widely	RB	RB	_	13	advmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	in	in	IN	IN	_	20	case	_	_
20	granuloctyes	granuloctye	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	conj	_	_
25	,	,	,	,	_	16	punct	_	_
26	than	than	IN	IN	_	27	case	_	_
27	previously	previously	RB	RB	_	16	nmod	_	_
28	reported	report	VBN	VBN	_	27	amod	_	_
29	with	with	IN	IN	_	31	case	_	_
30	other	other	JJ	JJ	_	31	amod	_	_
31	methods	method	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	found	find	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	deviation	deviation	NN	NN	_	16	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	methylation	methylation	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	10	case	_	_
10	granulocytes	granulocyte	NNS	NNS	_	6	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	conj	_	_
14	was	be	VBD	VBD	_	16	auxpass	_	_
15	well	well	RB	RB	_	16	advmod	_	_
16	correlated	correlate	VBN	VBN	_	3	ccomp	_	_
17	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	conclude	conclude	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	28	mark	_	_
6	appropriate	appropriate	JJ	JJ	_	7	amod	_	_
7	controls	control	NNS	NNS	_	28	nsubjpass	_	_
8	from	from	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	same	same	JJ	JJ	_	11	amod	_	_
11	individuals	individual	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	such	such	JJ	JJ	_	16	case	_	_
14	as	as	IN	IN	_	13	mwe	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	case	case	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	stem	stem	NN	NN	_	23	compound	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	disorders	disorder	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	7	punct	_	_
25	should	should	MD	MD	_	28	aux	_	_
26	always	always	RB	RB	_	28	advmod	_	_
27	be	be	VB	VB	_	28	auxpass	_	_
28	employed	employ	VBN	VBN	_	4	ccomp	_	_
29	to	to	TO	TO	_	31	mark	_	_
30	conclusively	conclusively	RB	RB	_	31	advmod	_	_
31	determine	determine	VB	VB	_	28	xcomp	_	_
32	whether	whether	IN	IN	_	39	mark	_	_
33	certain	certain	JJ	JJ	_	34	amod	_	_
34	cells	cell	NNS	NNS	_	39	nsubj	_	_
35	of	of	IN	IN	_	37	case	_	_
36	hematopoietic	hematopoietic	JJ	JJ	_	37	amod	_	_
37	origin	origin	NN	NN	_	34	nmod	_	_
38	are	be	VBP	VBP	_	39	cop	_	_
39	clonal	clonal	JJ	JJ	_	31	ccomp	_	_
40	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	7	amod	_	_
3	virus	virus	NN	NN	_	7	compound	_	_
4	oncoprotein	oncoprotein	NN	NN	_	7	compound	_	_
5	latent	latent	JJ	JJ	_	7	amod	_	_
6	membrane	membrane	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	9	nsubj	_	_
8	1	1	CD	CD	_	7	nummod	_	_
9	engages	engage	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	16	dep	_	_
11	tumor	tumor	NN	NN	_	16	compound	_	_
12	necrosis	necrosis	NN	NN	_	16	compound	_	_
13	factor	factor	NN	NN	_	16	compound	_	_
14	receptor-associated	receptor-associated	JJ	JJ	_	16	amod	_	_
15	proteins	protein	NNS	NNS	_	16	compound	_	_
16	TRADD	tradd	NN	NN	_	9	dobj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	receptor-interacting	receptor-interacting	JJ	JJ	_	19	amod	_	_
19	protein	protein	NN	NN	_	16	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	RIP	rip	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	but	but	CC	CC	_	9	cc	_	_
24	does	do	VBZ	VBZ	_	26	aux	_	_
25	not	not	RB	RB	_	26	neg	_	_
26	induce	induce	VB	VB	_	9	conj	_	_
27	apoptosis	apoptosis	NN	NN	_	26	dobj	_	_
28	or	or	CC	CC	_	26	cc	_	_
29	require	require	VB	VB	_	26	conj	_	_
30	RIP	rip	NN	NN	_	29	dobj	_	_
31	for	for	IN	IN	_	33	case	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	33	compound	_	_
33	activation	activation	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	site	site	NN	NN	_	40	nsubj	_	_
3	in	in	IN	IN	_	12	case	_	_
4	the	the	DT	DT	_	12	det	_	_
5	Epstein-Barr	epstein-barr	JJ	JJ	_	12	amod	_	_
6	virus	virus	NN	NN	_	12	compound	_	_
7	(	(	-LRB-	-LRB-	_	12	punct	_	_
8	EBV	ebv	NN	NN	_	12	compound	_	_
9	)	)	-RRB-	-RRB-	_	12	punct	_	_
10	transforming	transforming	NN	NN	_	12	compound	_	_
11	protein	protein	NN	NN	_	12	compound	_	_
12	LMP1	lmp1	NN	NN	_	2	nmod	_	_
13	that	that	WDT	WDT	_	15	nsubj	_	_
14	constitutively	constitutively	RB	RB	_	15	advmod	_	_
15	associates	associate	VBZ	VBZ	_	12	acl:relcl	_	_
16	with	with	IN	IN	_	30	case	_	_
17	the	the	DT	DT	_	30	det	_	_
18	tumor	tumor	NN	NN	_	30	compound	_	_
19	necrosis	necrosis	NN	NN	_	30	compound	_	_
20	factor	factor	NN	NN	_	30	compound	_	_
21	receptor	receptor	NN	NN	_	30	compound	_	_
22	1	1	CD	CD	_	30	nummod	_	_
23	(	(	-LRB-	-LRB-	_	30	punct	_	_
24	TNFR1	tnfr1	NN	NN	_	30	compound	_	_
25	)	)	-RRB-	-RRB-	_	30	punct	_	_
26	-associated	-associated	JJ	JJ	_	30	amod	_	_
27	death	death	NN	NN	_	30	compound	_	_
28	domain	domain	NN	NN	_	30	compound	_	_
29	protein	protein	NN	NN	_	30	compound	_	_
30	TRADD	tradd	NN	NN	_	15	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	mediate	mediate	VB	VB	_	15	xcomp	_	_
33	NF-kappaB	nf-kappab	NN	NN	_	32	dobj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	c-Jun	c-jun	NN	NN	_	38	compound	_	_
36	N-terminal	n-terminal	JJ	JJ	_	38	amod	_	_
37	kinase	kinase	NN	NN	_	38	compound	_	_
38	activation	activation	NN	NN	_	33	conj	_	_
39	is	be	VBZ	VBZ	_	40	cop	_	_
40	critical	critical	JJ	JJ	_	0	root	_	_
41	for	for	IN	IN	_	45	case	_	_
42	long-term	long-term	JJ	JJ	_	45	amod	_	_
43	lymphoblastoid	lymphoblastoid	JJ	JJ	_	45	amod	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	proliferation	proliferation	NN	NN	_	40	nmod	_	_
46	.	.	.	.	_	40	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	now	now	RB	RB	_	3	advmod	_	_
3	find	find	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	LMP1	lmp1	NN	NN	_	6	compound	_	_
6	signaling	signaling	NN	NN	_	9	nsubj	_	_
7	through	through	IN	IN	_	8	case	_	_
8	TRADD	tradd	NN	NN	_	6	nmod	_	_
9	differs	differ	VBZ	VBZ	_	3	ccomp	_	_
10	from	from	IN	IN	_	12	case	_	_
11	TNFR1	tnfr1	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	9	nmod	_	_
13	through	through	IN	IN	_	14	case	_	_
14	TRADD	tradd	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	LMP1	lmp1	NN	NN	_	2	nsubj	_	_
2	needs	need	VBZ	VBZ	_	0	root	_	_
3	only	only	RB	RB	_	4	advmod	_	_
4	11	11	CD	CD	_	6	nummod	_	_
5	amino	amino	NN	NN	_	6	compound	_	_
6	acids	acid	NNS	NNS	_	2	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	activate	activate	VB	VB	_	2	advcl	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	8	dobj	_	_
10	or	or	CC	CC	_	8	cc	_	_
11	synergize	synergize	VB	VB	_	8	conj	_	_
12	with	with	IN	IN	_	13	case	_	_
13	TRADD	tradd	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
16	activation	activation	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	2	punct	_	_
18	while	while	IN	IN	_	20	mark	_	_
19	TNFR1	tnfr1	NN	NN	_	20	nsubj	_	_
20	requires	require	VBZ	VBZ	_	2	advcl	_	_
21	approximately	approximately	RB	RB	_	22	advmod	_	_
22	70	70	CD	CD	_	23	nummod	_	_
23	residues	residue	NNS	NNS	_	20	dobj	_	_
24	.	.	.	.	_	2	punct	_	_

1	Further	further	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	LMP1	lmp1	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	require	require	VB	VB	_	0	root	_	_
7	TRADD	tradd	NN	NN	_	8	compound	_	_
8	residues	residue	NNS	NNS	_	6	dobj	_	_
9	294	294	CD	CD	_	8	dep	_	_
10	to	to	TO	TO	_	9	dep	_	_
11	312	312	CD	CD	_	9	dep	_	_
12	for	for	IN	IN	_	14	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	6	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	while	while	IN	IN	_	18	mark	_	_
17	TNFR1	tnfr1	NN	NN	_	18	nsubj	_	_
18	requires	require	VBZ	VBZ	_	6	advcl	_	_
19	TRADD	tradd	NN	NN	_	20	compound	_	_
20	residues	residue	NNS	NNS	_	18	dobj	_	_
21	296	296	CD	CD	_	20	dep	_	_
22	to	to	TO	TO	_	21	dep	_	_
23	302	302	CD	CD	_	21	dep	_	_
24	.	.	.	.	_	6	punct	_	_

1	LMP1	lmp1	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	partially	partially	RB	RB	_	4	advmod	_	_
4	blocked	block	VBN	VBN	_	0	root	_	_
5	for	for	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activation	activation	NN	NN	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	TRADD	tradd	NN	NN	_	11	compound	_	_
11	mutant	mutant	NN	NN	_	4	nmod	_	_
12	consisting	consist	VBG	VBG	_	11	acl	_	_
13	of	of	IN	IN	_	14	case	_	_
14	residues	residue	NNS	NNS	_	12	nmod	_	_
15	122	122	CD	CD	_	14	dep	_	_
16	to	to	TO	TO	_	15	dep	_	_
17	293	293	CD	CD	_	15	dep	_	_
18	.	.	.	.	_	4	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	TNFR1	tnfr1	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	LMP1	lmp1	NN	NN	_	6	nsubj	_	_
5	can	can	MD	MD	_	6	aux	_	_
6	interact	interact	VB	VB	_	0	root	_	_
7	directly	directly	RB	RB	_	6	advmod	_	_
8	with	with	IN	IN	_	10	case	_	_
9	receptor-interacting	receptor-interacting	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RIP	rip	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	and	and	CC	CC	_	6	cc	_	_
15	stably	stably	RB	RB	_	16	advmod	_	_
16	associates	associate	VBZ	VBZ	_	6	conj	_	_
17	with	with	IN	IN	_	18	case	_	_
18	RIP	rip	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	23	case	_	_
20	EBV-transformed	ebv-transformed	JJ	JJ	_	23	amod	_	_
21	lymphoblastoid	lymphoblastoid	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	LMP1	lmp1	NN	NN	_	6	nsubj	_	_
4	does	do	VBZ	VBZ	_	6	aux	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	require	require	VB	VB	_	0	root	_	_
7	RIP	rip	NN	NN	_	6	dobj	_	_
8	for	for	IN	IN	_	10	case	_	_
9	NF-kappaB	nf-kappab	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	6	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	Despite	despite	IN	IN	_	3	case	_	_
2	constitutive	constitutive	JJ	JJ	_	3	amod	_	_
3	association	association	NN	NN	_	12	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	TRADD	tradd	NN	NN	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	RIP	rip	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	12	punct	_	_
9	LMP1	lmp1	NN	NN	_	12	nsubj	_	_
10	does	do	VBZ	VBZ	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	induce	induce	VB	VB	_	0	root	_	_
13	apoptosis	apoptosis	NN	NN	_	12	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	EBV-negative	ebv-negative	JJ	JJ	_	17	amod	_	_
16	Burkitt	burkitt	NN	NN	_	17	compound	_	_
17	lymphoma	lymphoma	NN	NN	_	12	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	human	human	JJ	JJ	_	21	amod	_	_
20	embryonic	embryonic	JJ	JJ	_	21	amod	_	_
21	kidney	kidney	NN	NN	_	17	conj	_	_
22	293	293	CD	CD	_	21	nummod	_	_
23	cells	cell	NNS	NNS	_	17	dep	_	_
24	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	add	add	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	different	different	JJ	JJ	_	6	amod	_	_
6	perspective	perspective	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	molecular	molecular	JJ	JJ	_	10	amod	_	_
10	interactions	interaction	NNS	NNS	_	3	nmod	_	_
11	through	through	IN	IN	_	12	case	_	_
12	which	which	WDT	WDT	_	19	nmod	_	_
13	LMP1	lmp1	NN	NN	_	19	nsubj	_	_
14	,	,	,	,	_	13	punct	_	_
15	TRADD	tradd	NN	NN	_	13	conj	_	_
16	,	,	,	,	_	13	punct	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	RIP	rip	NN	NN	_	13	conj	_	_
19	participate	participate	VBP	VBP	_	10	acl:relcl	_	_
20	in	in	IN	IN	_	21	case	_	_
21	B-lymphocyte	b-lymphocyte	NN	NN	_	19	nmod	_	_
22	activation	activation	NN	NN	_	21	dep	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	growth	growth	NN	NN	_	22	conj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Regulatory	regulatory	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin-11	interleukin-11	NN	NN	_	2	nmod	_	_
5	during	during	IN	IN	_	9	case	_	_
6	acute	acute	JJ	JJ	_	9	amod	_	_
7	lung	lung	NN	NN	_	9	compound	_	_
8	inflammatory	inflammatory	JJ	JJ	_	9	amod	_	_
9	injury	injury	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	9	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	interleukin-11	interleukin-11	NN	NN	_	2	nmod	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	IL-11	il-11	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	evaluated	evaluate	VBN	VBN	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	the	the	DT	DT	_	15	det	_	_
12	IgG	igg	NN	NN	_	15	compound	_	_
13	immune	immune	JJ	JJ	_	15	amod	_	_
14	complex	complex	NN	NN	_	15	compound	_	_
15	model	model	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	acute	acute	JJ	JJ	_	19	amod	_	_
18	lung	lung	NN	NN	_	19	compound	_	_
19	injury	injury	NN	NN	_	15	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	rats	rat	NNS	NNS	_	19	nmod	_	_
22	.	.	.	.	_	9	punct	_	_

1	IL-11	il-11	NN	NN	_	2	compound	_	_
2	mRNA	mrna	NN	NN	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	protein	protein	NN	NN	_	2	conj	_	_
5	were	be	VBD	VBD	_	7	auxpass	_	_
6	both	both	DT	DT	_	7	advmod	_	_
7	up-regulated	up-regulate	VBN	VBN	_	0	root	_	_
8	during	during	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	course	course	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	this	this	DT	DT	_	14	det	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	response	response	NN	NN	_	10	nmod	_	_
15	.	.	.	.	_	7	punct	_	_

1	Exogenously	exogenously	RB	RB	_	2	advmod	_	_
2	administered	administer	VBN	VBN	_	3	amod	_	_
3	IL-11	il-11	NN	NN	_	5	nsubj	_	_
4	substantially	substantially	RB	RB	_	5	advmod	_	_
5	reduced	reduce	VBD	VBD	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	in	in	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	dose-dependent	dose-dependent	JJ	JJ	_	10	amod	_	_
10	manner	manner	NN	NN	_	5	nmod	_	_
11	,	,	,	,	_	5	punct	_	_
12	the	the	DT	DT	_	14	det	_	_
13	intrapulmonary	intrapulmonary	JJ	JJ	_	14	amod	_	_
14	accumulation	accumulation	NN	NN	_	5	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	neutrophils	neutrophil	NNS	NNS	_	14	nmod	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	the	the	DT	DT	_	21	det	_	_
19	lung	lung	NN	NN	_	21	compound	_	_
20	vascular	vascular	JJ	JJ	_	21	amod	_	_
21	leak	leak	NN	NN	_	14	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	albumin	albumin	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	These	these	DT	DT	_	5	det	_	_
2	in	in	FW	FW	_	5	amod	_	_
3	vivo	vivo	FW	FW	_	2	dep	_	_
4	anti-inflammatory	anti-inflammatory	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	9	nsubjpass	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-11	il-11	NN	NN	_	5	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	associated	associate	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	13	case	_	_
11	reduced	reduce	VBN	VBN	_	13	amod	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	lung	lung	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	13	punct	_	_
17	reduced	reduce	VBD	VBD	_	18	amod	_	_
18	levels	level	NNS	NNS	_	13	conj	_	_
19	of	of	IN	IN	_	23	case	_	_
20	tumor	tumor	NN	NN	_	23	compound	_	_
21	necrosis	necrosis	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	alpha	alpha	NN	NN	_	18	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	TNF-alpha	tnf-alpha	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	in	in	IN	IN	_	33	case	_	_
28	bronchoalveolar	bronchoalveolar	JJ	JJ	_	33	amod	_	_
29	lavage	lavage	NN	NN	_	33	compound	_	_
30	(	(	-LRB-	-LRB-	_	33	punct	_	_
31	BAL	bal	NN	NN	_	33	compound	_	_
32	)	)	-RRB-	-RRB-	_	33	punct	_	_
33	fluids	fluid	NNS	NNS	_	23	nmod	_	_
34	,	,	,	,	_	13	punct	_	_
35	and	and	CC	CC	_	13	cc	_	_
36	diminished	diminish	VBD	VBD	_	37	amod	_	_
37	up-regulation	up-regulation	NN	NN	_	13	conj	_	_
38	of	of	IN	IN	_	41	case	_	_
39	lung	lung	NN	NN	_	41	compound	_	_
40	vascular	vascular	JJ	JJ	_	41	amod	_	_
41	ICAM-1	icam-1	NN	NN	_	37	nmod	_	_
42	.	.	.	.	_	9	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	interesting	interesting	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	IL-11	il-11	NN	NN	_	8	nsubj	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	affect	affect	VB	VB	_	3	ccomp	_	_
9	BAL	bal	NN	NN	_	11	compound	_	_
10	fluid	fluid	JJ	JJ	_	11	amod	_	_
11	content	content	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	dep	_	_
14	CXC	cxc	NN	NN	_	15	compound	_	_
15	chemokines	chemokine	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	macrophage	macrophage	NN	NN	_	19	compound	_	_
18	inflammatory	inflammatory	JJ	JJ	_	19	amod	_	_
19	protein-2	protein-2	NN	NN	_	15	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MIP-2	mip-2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	cytokine-inducible	cytokine-inducible	JJ	JJ	_	26	amod	_	_
25	neutrophil	neutrophil	NN	NN	_	26	compound	_	_
26	chemoattractant	chemoattractant	NN	NN	_	15	conj	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	CINC	cinc	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	;	;	:	:	_	3	punct	_	_
31	the	the	DT	DT	_	32	det	_	_
32	presence	presence	NN	NN	_	37	nsubj	_	_
33	of	of	IN	IN	_	34	case	_	_
34	IL-11	il-11	NN	NN	_	32	nmod	_	_
35	did	do	VBD	VBD	_	37	aux	_	_
36	not	not	RB	RB	_	37	neg	_	_
37	affect	affect	VB	VB	_	3	parataxis	_	_
38	these	these	DT	DT	_	39	det	_	_
39	chemokines	chemokine	NNS	NNS	_	37	dobj	_	_
40	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	BAL	bal	NN	NN	_	4	compound	_	_
4	content	content	NN	NN	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	C5a	c5a	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	reduced	reduce	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	IL-11	il-11	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	IL-11	il-11	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	a	a	DT	DT	_	9	det	_	_
8	regulatory	regulatory	JJ	JJ	_	9	amod	_	_
9	cytokine	cytokine	NN	NN	_	3	ccomp	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	lung	lung	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	that	that	IN	IN	_	26	mark	_	_
15	,	,	,	,	_	26	punct	_	_
16	like	like	IN	IN	_	18	case	_	_
17	other	other	JJ	JJ	_	18	amod	_	_
18	members	member	NNS	NNS	_	26	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	this	this	DT	DT	_	21	det	_	_
21	family	family	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	26	punct	_	_
23	its	its	PRP$	PRP$	_	25	nmod:poss	_	_
24	anti-inflammatory	anti-inflammatory	JJ	JJ	_	25	amod	_	_
25	properties	property	NNS	NNS	_	26	nsubj	_	_
26	appear	appear	VBP	VBP	_	9	conj	_	_
27	to	to	TO	TO	_	29	mark	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	linked	link	VBN	VBN	_	26	xcomp	_	_
30	to	to	TO	TO	_	32	case	_	_
31	its	its	PRP$	PRP$	_	32	nmod:poss	_	_
32	suppression	suppression	NN	NN	_	29	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	NF-kappaB	nf-kappab	NN	NN	_	35	compound	_	_
35	activation	activation	NN	NN	_	32	nmod	_	_
36	,	,	,	,	_	32	punct	_	_
37	diminished	diminish	VBN	VBN	_	38	amod	_	_
38	production	production	NN	NN	_	32	conj	_	_
39	of	of	IN	IN	_	40	case	_	_
40	TNF-alpha	tnf-alpha	NN	NN	_	38	nmod	_	_
41	,	,	,	,	_	32	punct	_	_
42	and	and	CC	CC	_	32	cc	_	_
43	reduced	reduce	VBN	VBN	_	44	amod	_	_
44	up-regulation	up-regulation	NN	NN	_	32	conj	_	_
45	of	of	IN	IN	_	48	case	_	_
46	lung	lung	NN	NN	_	48	compound	_	_
47	vascular	vascular	JJ	JJ	_	48	amod	_	_
48	ICAM-1	icam-1	NN	NN	_	44	nmod	_	_
49	.	.	.	.	_	3	punct	_	_

1	ETS	ets	NN	NN	_	3	compound	_	_
2	transcription	transcription	NN	NN	_	3	compound	_	_
3	factors	factor	NNS	NNS	_	4	nsubj	_	_
4	regulate	regulate	VBP	VBP	_	0	root	_	_
5	an	a	DT	DT	_	7	det	_	_
6	enhancer	enhancer	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	third	third	JJ	JJ	_	11	amod	_	_
11	intron	intron	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	11	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	describe	describe	VBP	VBP	_	0	root	_	_
3	an	a	DT	DT	_	5	det	_	_
4	enhancer	enhancer	NN	NN	_	5	compound	_	_
5	site	site	NN	NN	_	2	dobj	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	third	third	JJ	JJ	_	9	amod	_	_
9	intron	intron	NN	NN	_	2	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	tumor	tumor	NN	NN	_	14	compound	_	_
12	necrosis	necrosis	NN	NN	_	14	compound	_	_
13	factor	factor	NN	NN	_	14	compound	_	_
14	alpha	alpha	NN	NN	_	9	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	TNF-alpha	tnf-alpha	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	2	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	reporter	reporter	NN	NN	_	3	compound	_	_
3	construct	construct	NN	NN	_	13	nsubj	_	_
4	containing	contain	VBG	VBG	_	3	acl	_	_
5	the	the	DT	DT	_	7	det	_	_
6	5'-flanking	5'-flanking	JJ	JJ	_	7	amod	_	_
7	region	region	NN	NN	_	4	dobj	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	mouse	mouse	NN	NN	_	12	compound	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	12	compound	_	_
12	gene	gene	NN	NN	_	7	nmod	_	_
13	displayed	display	VBD	VBD	_	0	root	_	_
14	weak	weak	JJ	JJ	_	15	amod	_	_
15	activity	activity	NN	NN	_	13	dobj	_	_
16	when	when	WRB	WRB	_	17	advmod	_	_
17	transfected	transfect	VBN	VBN	_	13	advcl	_	_
18	into	into	IN	IN	_	21	case	_	_
19	RAW264.7	raw264.7	NN	NN	_	21	compound	_	_
20	macrophage-like	macrophage-like	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	.	.	.	.	_	13	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	12	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	third	third	JJ	JJ	_	6	amod	_	_
6	intron	intron	NN	NN	_	2	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	11	case	_	_
10	this	this	DT	DT	_	11	det	_	_
11	construct	construct	NN	NN	_	2	nmod	_	_
12	resulted	result	VBD	VBD	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	enhancement	enhancement	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	CAT	cat	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	12	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	enhancement	enhancement	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	eliminated	eliminate	VBN	VBN	_	0	root	_	_
5	if	if	IN	IN	_	11	mark	_	_
6	a	a	DT	DT	_	9	det	_	_
7	conserved	conserve	VBN	VBN	_	9	amod	_	_
8	20-bp	20-bp	JJ	JJ	_	9	amod	_	_
9	sequence	sequence	NN	NN	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	removed	remove	VBN	VBN	_	4	advcl	_	_
12	from	from	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	intron	intron	NN	NN	_	11	nmod	_	_
15	or	or	CC	CC	_	11	cc	_	_
16	if	if	IN	IN	_	22	mark	_	_
17	a	a	DT	DT	_	20	det	_	_
18	dominant-negative	dominant-negative	JJ	JJ	_	20	amod	_	_
19	ets-binding	ets-binding	JJ	JJ	_	20	amod	_	_
20	factor	factor	NN	NN	_	22	nsubjpass	_	_
21	was	be	VBD	VBD	_	22	auxpass	_	_
22	co-transfected	co-transfect	VBN	VBN	_	11	conj	_	_
23	with	with	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	reporter	reporter	NN	NN	_	26	compound	_	_
26	gene	gene	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	Mutations	mutation	NNS	NNS	_	14	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	this	this	DT	DT	_	4	det	_	_
4	site	site	NN	NN	_	1	nmod	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	destroyed	destroy	VBD	VBD	_	4	acl:relcl	_	_
7	potential	potential	JJ	JJ	_	12	amod	_	_
8	ets	ets	NN	NN	_	12	compound	_	_
9	transcription	transcription	NN	NN	_	12	compound	_	_
10	factor	factor	NN	NN	_	12	compound	_	_
11	binding	binding	NN	NN	_	12	compound	_	_
12	sites	site	NNS	NNS	_	6	dobj	_	_
13	had	have	VBD	VBD	_	14	aux	_	_
14	reduced	reduce	VBN	VBN	_	0	root	_	_
15	transcriptional	transcriptional	JJ	JJ	_	16	amod	_	_
16	activity	activity	NN	NN	_	14	dobj	_	_
17	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	major	major	JJ	JJ	_	4	amod	_	_
3	transcription	transcription	NN	NN	_	4	compound	_	_
4	factor	factor	NN	NN	_	11	nsubjpass	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	bound	bind	VBD	VBD	_	4	acl:relcl	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	oligonucleotide	oligonucleotide	NN	NN	_	6	nmod	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	confirmed	confirm	VBN	VBN	_	0	root	_	_
12	to	to	TO	TO	_	14	mark	_	_
13	be	be	VB	VB	_	14	cop	_	_
14	GABP	gabp	NN	NN	_	11	xcomp	_	_
15	by	by	IN	IN	_	19	case	_	_
16	supershift	supershift	NN	NN	_	19	compound	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	competition	competition	NN	NN	_	16	conj	_	_
19	analysis	analysis	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	RAW264.7	raw264.7	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	binding	binding	NN	NN	_	8	nsubj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	constitutive	constitutive	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	however	however	RB	RB	_	19	advmod	_	_
11	,	,	,	,	_	19	punct	_	_
12	in	in	IN	IN	_	15	case	_	_
13	bone	bone	NN	NN	_	15	compound	_	_
14	marrow-derived	marrow-derived	JJ	JJ	_	15	amod	_	_
15	macrophages	macrophage	NNS	NNS	_	19	nmod	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	19	nsubjpass	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	shown	show	VBN	VBN	_	8	parataxis	_	_
20	to	to	TO	TO	_	23	mark	_	_
21	be	be	VB	VB	_	23	cop	_	_
22	interferon-gamma	interferon-gamma	NN	NN	_	23	nmod:npmod	_	_
23	inducible	inducible	JJ	JJ	_	19	xcomp	_	_
24	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	imply	imply	VB	VB	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	3	dobj	_	_
6	for	for	IN	IN	_	9	case	_	_
7	ets	ets	NN	NN	_	9	compound	_	_
8	transcription	transcription	NN	NN	_	9	compound	_	_
9	factors	factor	NNS	NNS	_	5	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	production	production	NN	NN	_	3	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	12	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Abnormal	abnormal	JJ	JJ	_	4	amod	_	_
2	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
3	B	b	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	15	nsubjpass	_	_
5	in	in	IN	IN	_	7	case	_	_
6	T	t	NN	NN	_	7	compound	_	_
7	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
8	from	from	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	13	case	_	_
11	systemic	systemic	JJ	JJ	_	13	amod	_	_
12	lupus	lupus	NN	NN	_	13	compound	_	_
13	erythematosus	erythematosus	NN	NN	_	9	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	associated	associate	VBN	VBN	_	0	root	_	_
16	with	with	IN	IN	_	20	case	_	_
17	decreased	decrease	VBN	VBN	_	20	amod	_	_
18	p65-RelA	p65-rela	NN	NN	_	20	compound	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	Numerous	numerous	JJ	JJ	_	5	amod	_	_
2	cellular	cellular	JJ	JJ	_	5	amod	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	biochemical	biochemical	JJ	JJ	_	2	conj	_	_
5	abnormalities	abnormality	NNS	NNS	_	11	nsubjpass	_	_
6	in	in	IN	IN	_	8	case	_	_
7	immune	immune	JJ	JJ	_	8	amod	_	_
8	regulation	regulation	NN	NN	_	5	nmod	_	_
9	have	have	VBP	VBP	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	described	describe	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	patients	patient	NNS	NNS	_	11	nmod	_	_
14	with	with	IN	IN	_	17	case	_	_
15	systemic	systemic	JJ	JJ	_	17	amod	_	_
16	lupus	lupus	NN	NN	_	17	compound	_	_
17	erythematosus	erythematosus	NN	NN	_	13	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SLE	sle	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	,	,	,	,	_	11	punct	_	_
22	including	include	VBG	VBG	_	27	case	_	_
23	surface	surface	NN	NN	_	27	compound	_	_
24	Ag	ag	NN	NN	_	27	compound	_	_
25	receptor-initiated	receptor-initiated	JJ	JJ	_	27	amod	_	_
26	signaling	signaling	NN	NN	_	27	compound	_	_
27	events	event	NNS	NNS	_	11	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	lymphokine	lymphokine	JJ	JJ	_	30	amod	_	_
30	production	production	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	11	punct	_	_

1	Because	because	IN	IN	_	4	mark	_	_
2	NF-kappa	nf-kappa	NN	NN	_	3	compound	_	_
3	B	b	NN	NN	_	4	nsubj	_	_
4	contributes	contribute	VBZ	VBZ	_	26	advcl	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	transcription	transcription	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	numerous	numerous	JJ	JJ	_	11	amod	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	7	nmod	_	_
12	and	and	CC	CC	_	4	cc	_	_
13	has	have	VBZ	VBZ	_	15	aux	_	_
14	been	be	VBN	VBN	_	15	auxpass	_	_
15	shown	show	VBN	VBN	_	4	conj	_	_
16	to	to	TO	TO	_	20	mark	_	_
17	be	be	VB	VB	_	20	cop	_	_
18	a	a	DT	DT	_	20	det	_	_
19	molecular	molecular	JJ	JJ	_	20	amod	_	_
20	target	target	NN	NN	_	15	xcomp	_	_
21	of	of	IN	IN	_	23	case	_	_
22	antiinflammatory	antiinflammatory	JJ	JJ	_	23	amod	_	_
23	drugs	drug	NNS	NNS	_	20	nmod	_	_
24	,	,	,	,	_	26	punct	_	_
25	we	we	PRP	PRP	_	26	nsubj	_	_
26	sought	seek	VBD	VBD	_	0	root	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	characterize	characterize	VB	VB	_	26	xcomp	_	_
29	the	the	DT	DT	_	31	det	_	_
30	functional	functional	JJ	JJ	_	31	amod	_	_
31	role	role	NN	NN	_	28	dobj	_	_
32	of	of	IN	IN	_	37	case	_	_
33	the	the	DT	DT	_	37	det	_	_
34	NF-kappa	nf-kappa	NN	NN	_	37	compound	_	_
35	B	b	NN	NN	_	37	compound	_	_
36	protein	protein	NN	NN	_	37	compound	_	_
37	complex	complex	NN	NN	_	31	nmod	_	_
38	in	in	IN	IN	_	41	case	_	_
39	lupus	lupus	JJ	JJ	_	41	amod	_	_
40	T	t	NN	NN	_	41	compound	_	_
41	cells	cell	NNS	NNS	_	31	nmod	_	_
42	.	.	.	.	_	26	punct	_	_

1	Freshly	freshly	RB	RB	_	4	advmod	_	_
2	isolated	isolate	VBN	VBN	_	4	amod	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	20	nsubjpass	_	_
5	from	from	IN	IN	_	7	case	_	_
6	lupus	lupus	NN	NN	_	7	compound	_	_
7	patients	patient	NNS	NNS	_	4	nmod	_	_
8	,	,	,	,	_	7	punct	_	_
9	rheumatoid	rheumatoid	JJ	JJ	_	10	amod	_	_
10	arthritis	arthritis	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RA	ra	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	patients	patient	NNS	NNS	_	7	conj	_	_
15	,	,	,	,	_	7	punct	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	normal	normal	JJ	JJ	_	18	amod	_	_
18	individuals	individual	NNS	NNS	_	7	conj	_	_
19	were	be	VBD	VBD	_	20	auxpass	_	_
20	activated	activate	VBN	VBN	_	0	root	_	_
21	physiologically	physiologically	RB	RB	_	20	advmod	_	_
22	via	via	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	TCR	tcr	NN	NN	_	20	nmod	_	_
25	with	with	IN	IN	_	26	case	_	_
26	anti-CD3	anti-cd3	JJ	JJ	_	31	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	anti-CD28	anti-cd28	JJ	JJ	_	29	amod	_	_
29	Abs	ab	NNS	NNS	_	26	conj	_	_
30	to	to	TO	TO	_	31	mark	_	_
31	assess	assess	VB	VB	_	20	xcomp	_	_
32	proximal	proximal	JJ	JJ	_	34	amod	_	_
33	membrane	membrane	NN	NN	_	34	compound	_	_
34	signaling	signaling	NN	NN	_	31	dobj	_	_
35	,	,	,	,	_	31	punct	_	_
36	and	and	CC	CC	_	31	cc	_	_
37	with	with	IN	IN	_	38	case	_	_
38	PMA	pma	NN	NN	_	47	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	a	a	DT	DT	_	42	det	_	_
41	calcium	calcium	NN	NN	_	42	compound	_	_
42	ionophore	ionophore	NN	NN	_	38	conj	_	_
43	(	(	-LRB-	-LRB-	_	44	punct	_	_
44	A23187	a23187	NN	NN	_	42	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	to	to	TO	TO	_	47	mark	_	_
47	bypass	bypass	VB	VB	_	31	conj	_	_
48	membrane-mediated	membrane-mediated	JJ	JJ	_	50	amod	_	_
49	signaling	signaling	NN	NN	_	50	compound	_	_
50	events	event	NNS	NNS	_	47	dobj	_	_
51	.	.	.	.	_	20	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	measured	measure	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	7	det	_	_
4	NF-kappa	nf-kappa	NN	NN	_	7	compound	_	_
5	B	b	NN	NN	_	7	compound	_	_
6	binding	binding	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	2	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	extracts	extract	NNS	NNS	_	7	nmod	_	_
11	by	by	IN	IN	_	14	case	_	_
12	gel	gel	NN	NN	_	14	compound	_	_
13	shift	shift	NN	NN	_	14	compound	_	_
14	analysis	analysis	NN	NN	_	2	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	compared	compare	VBN	VBN	_	18	advcl	_	_
3	with	with	IN	IN	_	5	case	_	_
4	normal	normal	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	18	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activation	activation	NN	NN	_	18	nsubjpass	_	_
9	of	of	IN	IN	_	12	case	_	_
10	NF-kappa	nf-kappa	NN	NN	_	12	compound	_	_
11	B	b	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	SLE	sle	NN	NN	_	15	compound	_	_
15	patients	patient	NNS	NNS	_	8	nmod	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	significantly	significantly	RB	RB	_	18	advmod	_	_
18	decreased	decrease	VBN	VBN	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	SLE	sle	NN	NN	_	27	nmod	_	_
21	,	,	,	,	_	27	punct	_	_
22	but	but	CC	CC	_	27	cc	_	_
23	not	not	RB	RB	_	25	neg	_	_
24	in	in	IN	IN	_	25	case	_	_
25	RA	ra	NN	NN	_	27	conj	_	_
26	,	,	,	,	_	27	punct	_	_
27	patients	patient	NNS	NNS	_	18	nmod	_	_
28	.	.	.	.	_	18	punct	_	_

1	NF-kappa	nf-kappa	NN	NN	_	4	compound	_	_
2	B	b	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	absent	absent	JJ	JJ	_	0	root	_	_
7	in	in	IN	IN	_	10	case	_	_
8	several	several	JJ	JJ	_	10	amod	_	_
9	SLE	sle	NN	NN	_	10	compound	_	_
10	patients	patient	NNS	NNS	_	6	nmod	_	_
11	who	who	WP	WP	_	14	nsubj	_	_
12	were	be	VBD	VBD	_	14	aux	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	receiving	receive	VBG	VBG	_	10	acl:relcl	_	_
15	any	any	DT	DT	_	16	det	_	_
16	medication	medication	NN	NN	_	14	dobj	_	_
17	,	,	,	,	_	16	punct	_	_
18	including	include	VBG	VBG	_	19	case	_	_
19	corticosteroids	corticosteroid	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Also	also	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
4	B	b	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	6	nsubj	_	_
6	remained	remain	VBD	VBD	_	0	root	_	_
7	absent	absent	JJ	JJ	_	6	xcomp	_	_
8	in	in	IN	IN	_	10	case	_	_
9	follow-up	follow-up	JJ	JJ	_	10	amod	_	_
10	studies	study	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	supershift	supershift	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	9	nmod	_	_
4	using	use	VBG	VBG	_	3	acl	_	_
5	specific	specific	JJ	JJ	_	6	amod	_	_
6	Abs	ab	NNS	NNS	_	4	dobj	_	_
7	,	,	,	,	_	9	punct	_	_
8	we	we	PRP	PRP	_	9	nsubj	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	29	mark	_	_
11	,	,	,	,	_	29	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	group	group	NN	NN	_	29	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	SLE	sle	NN	NN	_	17	compound	_	_
17	patients	patient	NNS	NNS	_	14	nmod	_	_
18	who	who	WP	WP	_	19	nsubj	_	_
19	displayed	display	VBD	VBD	_	17	acl:relcl	_	_
20	undetectable	undetectable	JJ	JJ	_	23	amod	_	_
21	NF-kappa	nf-kappa	NN	NN	_	23	compound	_	_
22	B	b	NN	NN	_	23	compound	_	_
23	activity	activity	NN	NN	_	19	dobj	_	_
24	,	,	,	,	_	29	punct	_	_
25	p65	p65	NN	NN	_	26	compound	_	_
26	complexes	complex	NNS	NNS	_	29	nsubjpass	_	_
27	were	be	VBD	VBD	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	formed	form	VBN	VBN	_	9	ccomp	_	_
30	.	.	.	.	_	9	punct	_	_

1	Finally	finally	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	immunoblot	immunoblot	NN	NN	_	4	compound	_	_
4	analysis	analysis	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	extracts	extract	NNS	NNS	_	4	nmod	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	decreased	decrease	VBN	VBN	_	14	amod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	absent	absent	JJ	JJ	_	9	conj	_	_
12	p65	p65	NN	NN	_	14	compound	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	levels	level	NNS	NNS	_	8	dobj	_	_
15	.	.	.	.	_	8	punct	_	_

1	As	as	IN	IN	_	6	mark	_	_
2	p65	p65	NN	NN	_	3	compound	_	_
3	complexes	complex	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	transcriptionally	transcriptionally	RB	RB	_	6	advmod	_	_
6	active	active	JJ	JJ	_	18	advcl	_	_
7	in	in	IN	IN	_	8	case	_	_
8	comparison	comparison	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	p50	p50	NN	NN	_	12	compound	_	_
12	homodimer	homodimer	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	18	punct	_	_
14	this	this	DT	DT	_	16	det	_	_
15	novel	novel	JJ	JJ	_	16	amod	_	_
16	finding	finding	NN	NN	_	18	nsubj	_	_
17	may	may	MD	MD	_	18	aux	_	_
18	provide	provide	VB	VB	_	0	root	_	_
19	insight	insight	NN	NN	_	18	dobj	_	_
20	on	on	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	origin	origin	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	abnormal	abnormal	JJ	JJ	_	25	amod	_	_
25	cytokine	cytokine	NN	NN	_	22	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	other	other	JJ	JJ	_	29	amod	_	_
28	gene	gene	NN	NN	_	29	compound	_	_
29	transcription	transcription	NN	NN	_	25	conj	_	_
30	in	in	IN	IN	_	32	case	_	_
31	SLE	sle	NN	NN	_	32	compound	_	_
32	patients	patient	NNS	NNS	_	25	nmod	_	_
33	.	.	.	.	_	18	punct	_	_

1	Possible	possible	JJ	JJ	_	2	amod	_	_
2	differences	difference	NNS	NNS	_	0	root	_	_
3	in	in	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	mechanism	mechanism	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	s	s	NNS	NNS	_	2	nmod	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	of	of	IN	IN	_	10	case	_	_
10	action	action	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	15	case	_	_
12	different	different	JJ	JJ	_	15	amod	_	_
13	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
14	hormone	hormone	NN	NN	_	15	compound	_	_
15	compounds	compound	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	Different	different	JJ	JJ	_	5	amod	_	_
2	glucocorticoid	glucocorticoid	NN	NN	_	5	compound	_	_
3	hormones	hormone	NNS	NNS	_	5	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	GCH	gch	NN	NN	_	7	nsubj	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	differences	difference	NNS	NNS	_	7	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	intensity	intensity	NN	NN	_	7	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	kinetics	kinetics	NNS	NNS	_	11	conj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	their	they	PRP$	PRP$	_	19	nmod:poss	_	_
18	immunomodulating	immunomodulating	JJ	JJ	_	19	amod	_	_
19	activity	activity	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	12	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	s	s	NNS	NNS	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	of	of	IN	IN	_	7	case	_	_
7	action	action	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	GCH	gch	NN	NN	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	under	under	IN	IN	_	12	case	_	_
12	investigation	investigation	NN	NN	_	0	root	_	_
13	,	,	,	,	_	12	punct	_	_
14	but	but	CC	CC	_	12	cc	_	_
15	is	be	VBZ	VBZ	_	18	aux	_	_
16	has	have	VBZ	VBZ	_	18	aux	_	_
17	been	be	VBN	VBN	_	18	auxpass	_	_
18	noted	note	VBN	VBN	_	12	conj	_	_
19	that	that	IN	IN	_	21	mark	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	exert	exert	VBP	VBP	_	18	ccomp	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	activity	activity	NN	NN	_	21	dobj	_	_
24	via	via	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	genomic	genomic	JJ	JJ	_	27	amod	_	_
27	pathway	pathway	NN	NN	_	21	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	studied	study	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	prednisone	prednisone	NN	NN	_	9	compound	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	PDN	pdn	NN	NN	_	5	nmod	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	,	,	,	,	_	9	punct	_	_
12	deflazacort	deflazacort	NN	NN	_	14	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	DFC	dfc	NN	NN	_	9	conj	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	9	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	dexamethasone	dexamethasone	NN	NN	_	20	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	DXM	dxm	NN	NN	_	9	conj	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	on	on	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	production	production	NN	NN	_	5	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	cytokines	cytokine	NNS	NNS	_	24	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	IL-2	il-2	NN	NN	_	26	nmod	_	_
29	,	,	,	,	_	28	punct	_	_
30	IL-6	il-6	NN	NN	_	28	appos	_	_
31	,	,	,	,	_	28	punct	_	_
32	TNF-alpha	tnf-alpha	NN	NN	_	28	appos	_	_
33	,	,	,	,	_	28	punct	_	_
34	IL-10	il-10	NN	NN	_	28	appos	_	_
35	)	)	-RRB-	-RRB-	_	28	punct	_	_
36	by	by	IN	IN	_	39	case	_	_
37	peripheral	peripheral	JJ	JJ	_	39	amod	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
40	,	,	,	,	_	5	punct	_	_
41	and	and	CC	CC	_	5	cc	_	_
42	the	the	DT	DT	_	43	det	_	_
43	effects	effect	NNS	NNS	_	5	conj	_	_
44	on	on	IN	IN	_	46	case	_	_
45	the	the	DT	DT	_	46	det	_	_
46	inhibition	inhibition	NN	NN	_	43	nmod	_	_
47	of	of	IN	IN	_	51	case	_	_
48	NF-kB	nf-kb	NN	NN	_	51	compound	_	_
49	DNA	dna	NN	NN	_	51	compound	_	_
50	binding	binding	NN	NN	_	51	compound	_	_
51	activity	activity	NN	NN	_	46	nmod	_	_
52	by	by	IN	IN	_	56	case	_	_
53	activated	activated	JJ	JJ	_	56	amod	_	_
54	Jurkat	jurkat	NN	NN	_	56	compound	_	_
55	cell	cell	NN	NN	_	56	compound	_	_
56	line	line	NN	NN	_	46	nmod	_	_
57	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	4	nsubj	_	_
3	obtained	obtain	VBN	VBN	_	2	acl	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	9	det	_	_
7	three	three	CD	CD	_	9	nummod	_	_
8	GCH	gch	NN	NN	_	9	compound	_	_
9	molecules	molecule	NNS	NNS	_	10	nsubj	_	_
10	exert	exert	VBP	VBP	_	4	ccomp	_	_
11	an	a	DT	DT	_	12	det	_	_
12	immunosuppression	immunosuppression	NN	NN	_	10	dobj	_	_
13	on	on	IN	IN	_	15	case	_	_
14	cytokine	cytokine	NN	NN	_	15	compound	_	_
15	production	production	NN	NN	_	12	nmod	_	_
16	by	by	IN	IN	_	18	case	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	12	cc	_	_
20	a	a	DT	DT	_	22	det	_	_
21	strong	strong	JJ	JJ	_	22	amod	_	_
22	decrease	decrease	NN	NN	_	12	conj	_	_
23	in	in	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
26	translocation	translocation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	NF-kB	nf-kb	NN	NN	_	26	nmod	_	_
29	in	in	IN	IN	_	31	case	_	_
30	Jurkat	jurkat	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	;	;	:	:	_	4	punct	_	_
33	moreover	moreover	RB	RB	_	44	advmod	_	_
34	,	,	,	,	_	44	punct	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	a	a	LS	LS	_	44	dep	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	not	not	RB	RB	_	41	neg	_	_
39	all	all	PDT	PDT	_	41	det:predet	_	_
40	the	the	DT	DT	_	41	det	_	_
41	cytokines	cytokine	NNS	NNS	_	44	nsubjpass	_	_
42	investigated	investigate	VBN	VBN	_	41	acl	_	_
43	were	be	VBD	VBD	_	44	auxpass	_	_
44	affected	affect	VBN	VBN	_	4	parataxis	_	_
45	,	,	,	,	_	51	punct	_	_
46	and	and	CC	CC	_	51	cc	_	_
47	not	not	RB	RB	_	51	dep	_	_
48	with	with	IN	IN	_	51	case	_	_
49	the	the	DT	DT	_	51	det	_	_
50	same	same	JJ	JJ	_	51	amod	_	_
51	intensity	intensity	NN	NN	_	44	dep	_	_
52	,	,	,	,	_	51	punct	_	_
53	by	by	IN	IN	_	56	case	_	_
54	the	the	DT	DT	_	56	det	_	_
55	three	three	CD	CD	_	56	nummod	_	_
56	GCH	gch	NN	NN	_	44	nmod	_	_
57	and	and	CC	CC	_	44	cc	_	_
58	(	(	-LRB-	-LRB-	_	59	punct	_	_
59	b	b	LS	LS	_	62	dep	_	_
60	)	)	-RRB-	-RRB-	_	59	punct	_	_
61	DXM	dxm	NN	NN	_	62	nsubj	_	_
62	inhibited	inhibit	VBD	VBD	_	44	conj	_	_
63	the	the	DT	DT	_	65	det	_	_
64	binding	bind	VBG	VBG	_	65	amod	_	_
65	activity	activity	NN	NN	_	62	dobj	_	_
66	of	of	IN	IN	_	67	case	_	_
67	NF-kB	nf-kb	NN	NN	_	65	nmod	_	_
68	less	less	CC	CC	_	62	advmod	_	_
69	than	than	IN	IN	_	70	case	_	_
70	that	that	DT	DT	_	68	nmod	_	_
71	of	of	IN	IN	_	72	case	_	_
72	DFC	dfc	NN	NN	_	70	nmod	_	_
73	and	and	CC	CC	_	72	cc	_	_
74	PDN	pdn	NN	NN	_	72	conj	_	_
75	.	.	.	.	_	4	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	in	in	IN	IN	_	5	case	_	_
5	agreement	agreement	NN	NN	_	0	root	_	_
6	with	with	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	concept	concept	NN	NN	_	5	nmod	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	different	different	JJ	JJ	_	12	amod	_	_
11	GCH	gch	NN	NN	_	12	compound	_	_
12	compounds	compound	NNS	NNS	_	14	nsubj	_	_
13	might	might	MD	MD	_	14	aux	_	_
14	differ	differ	VB	VB	_	8	dep	_	_
15	in	in	IN	IN	_	17	case	_	_
16	their	they	PRP$	PRP$	_	17	nmod:poss	_	_
17	binding	binding	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	affinity	affinity	NN	NN	_	20	compound	_	_
20	properties	property	NNS	NNS	_	17	conj	_	_
21	,	,	,	,	_	17	punct	_	_
22	tissue-specific	tissue-specific	JJ	JJ	_	23	amod	_	_
23	metabolism	metabolism	NN	NN	_	17	conj	_	_
24	,	,	,	,	_	17	punct	_	_
25	and	and	CC	CC	_	17	cc	_	_
26	interaction	interaction	NN	NN	_	17	conj	_	_
27	with	with	IN	IN	_	29	case	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	p53	p53	NN	NN	_	3	compound	_	_
3	paradox	paradox	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	pathogenesis	pathogenesis	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	tumor	tumor	NN	NN	_	9	compound	_	_
9	progression	progression	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	3	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	16	dep	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	p53	p53	NN	NN	_	7	compound	_	_
7	molecule	molecule	NN	NN	_	8	nsubj	_	_
8	appears	appear	VBZ	VBZ	_	3	ccomp	_	_
9	in	in	IN	IN	_	12	case	_	_
10	two	two	CD	CD	_	12	nummod	_	_
11	different	different	JJ	JJ	_	12	amod	_	_
12	forms	form	NNS	NNS	_	8	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	the	the	DT	DT	_	16	dep	_	_
15	mutant	mutant	JJ	JJ	_	16	amod	_	_
16	p53	p53	NN	NN	_	0	root	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	stimulates	stimulate	VBZ	VBZ	_	16	acl:relcl	_	_
19	tumor	tumor	NN	NN	_	20	compound	_	_
20	progression	progression	NN	NN	_	18	dobj	_	_
21	,	,	,	,	_	16	punct	_	_
22	and	and	CC	CC	_	16	cc	_	_
23	wild	wild	JJ	JJ	_	25	amod	_	_
24	type	type	NN	NN	_	25	compound	_	_
25	p53	p53	NN	NN	_	16	conj	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	inhibits	inhibit	VBZ	VBZ	_	25	acl:relcl	_	_
28	tumor	tumor	NN	NN	_	29	compound	_	_
29	progression	progression	NN	NN	_	27	dobj	_	_
30	.	.	.	.	_	16	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	it	it	PRP	PRP	_	7	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	established	establish	VBN	VBN	_	0	root	_	_
8	that	that	IN	IN	_	16	mark	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor-alpha	factor-alpha	NN	NN	_	16	nsubj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TNF-alpha	tnf-alpha	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	can	can	MD	MD	_	16	aux	_	_
16	activate	activate	VB	VB	_	7	ccomp	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	wild	wild	JJ	JJ	_	22	amod	_	_
21	type	type	NN	NN	_	22	compound	_	_
22	p53	p53	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	concert	concert	NN	NN	_	16	nmod	_	_
25	with	with	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
28	transcription	transcription	NN	NN	_	29	compound	_	_
29	factor	factor	NN	NN	_	24	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	NF-kappa	nf-kappa	NN	NN	_	32	compound	_	_
32	B	b	NN	NN	_	29	appos	_	_
33	.	.	.	.	_	7	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	TNF-alpha	tnf-alpha	NN	NN	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-kappa	nf-kappa	NN	NN	_	5	compound	_	_
5	B	b	NN	NN	_	2	conj	_	_
6	are	be	VBP	VBP	_	8	auxpass	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	involved	involve	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	stimulation	stimulation	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pathway	pathway	NN	NN	_	11	nmod	_	_
15	that	that	WDT	WDT	_	16	nsubj	_	_
16	leads	lead	VBZ	VBZ	_	14	acl:relcl	_	_
17	to	to	TO	TO	_	19	case	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	29	case	_	_
21	major	major	JJ	JJ	_	29	amod	_	_
22	histocompatibility	histocompatibility	NN	NN	_	29	compound	_	_
23	complex	complex	NN	NN	_	29	compound	_	_
24	(	(	-LRB-	-LRB-	_	29	punct	_	_
25	MHC	mhc	NN	NN	_	29	compound	_	_
26	)	)	-RRB-	-RRB-	_	29	punct	_	_
27	class	class	NN	NN	_	29	compound	_	_
28	I	i	CD	CD	_	29	nummod	_	_
29	molecules	molecule	NNS	NNS	_	19	nmod	_	_
30	and	and	CC	CC	_	19	cc	_	_
31	,	,	,	,	_	19	punct	_	_
32	hence	hence	RB	RB	_	19	advmod	_	_
33	,	,	,	,	_	19	punct	_	_
34	antigen	antigen	NN	NN	_	35	compound	_	_
35	presentation	presentation	NN	NN	_	19	conj	_	_
36	to	to	TO	TO	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	T	t	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	35	nmod	_	_
40	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	paper	paper	NN	NN	_	6	nmod	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	shall	shall	MD	MD	_	6	aux	_	_
6	advance	advance	VB	VB	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	hypothesis	hypothesis	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	:	:	:	:	_	16	punct	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	i	i	LS	LS	_	16	dep	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	TNF-alpha	tnf-alpha	NN	NN	_	16	nsubj	_	_
15	indirectly	indirectly	RB	RB	_	16	advmod	_	_
16	controls	control	VBZ	VBZ	_	8	dep	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	surveillance	surveillance	NN	NN	_	16	dobj	_	_
19	;	;	:	:	_	16	punct	_	_
20	and	and	CC	CC	_	16	cc	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	ii	ii	LS	LS	_	25	dep	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	TNF-alpha	tnf-alpha	NN	NN	_	25	nsubj	_	_
25	controls	control	VBZ	VBZ	_	16	conj	_	_
26	DNA	dna	NN	NN	_	27	compound	_	_
27	repair	repair	NN	NN	_	25	dobj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	tumor	tumor	NN	NN	_	30	compound	_	_
30	suppression	suppression	NN	NN	_	27	conj	_	_
31	through	through	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	regulation	regulation	NN	NN	_	25	nmod	_	_
34	of	of	IN	IN	_	37	case	_	_
35	wild	wild	JJ	JJ	_	37	amod	_	_
36	type	type	NN	NN	_	37	compound	_	_
37	p53	p53	NN	NN	_	33	nmod	_	_
38	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	it	it	PRP	PRP	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	hypothesized	hypothesize	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	11	mark	_	_
7	elevated	elevated	JJ	JJ	_	8	amod	_	_
8	TNF-alpha	tnf-alpha	NN	NN	_	11	nsubj	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	primarily	primarily	RB	RB	_	11	advmod	_	_
11	responsible	responsible	JJ	JJ	_	5	ccomp	_	_
12	for	for	IN	IN	_	13	mark	_	_
13	promoting	promote	VBG	VBG	_	11	advcl	_	_
14	tumor	tumor	NN	NN	_	15	compound	_	_
15	progression	progression	NN	NN	_	13	dobj	_	_
16	.	.	.	.	_	5	punct	_	_

1	Extracellular	extracellular	JJ	JJ	_	8	amod	_	_
2	signal-regulated	signal-regulated	JJ	JJ	_	8	amod	_	_
3	protein	protein	NN	NN	_	8	nmod:npmod	_	_
4	kinase	kinase	NN	NN	_	8	nmod:npmod	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	ERK	erk	NN	NN	_	8	nmod:npmod	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	-dependent	-dependent	JJ	JJ	_	11	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	ERK-independent	erk-independent	JJ	JJ	_	8	conj	_	_
11	pathways	pathway	NNS	NNS	_	12	nsubj	_	_
12	target	target	VBP	VBP	_	0	root	_	_
13	STAT3	stat3	NN	NN	_	12	dobj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	serine-727	serine-727	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	neutrophils	neutrophil	NNS	NNS	_	12	nmod	_	_
19	stimulated	stimulate	VBN	VBN	_	18	acl	_	_
20	by	by	IN	IN	_	22	case	_	_
21	chemotactic	chemotactic	JJ	JJ	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	cytokines	cytokine	NNS	NNS	_	22	conj	_	_
25	.	.	.	.	_	12	punct	_	_

1	STAT3	stat3	NN	NN	_	15	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	4	punct	_	_
3	signal	signal	NN	NN	_	4	compound	_	_
4	transducer	transducer	NN	NN	_	1	dep	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	activator	activator	NN	NN	_	8	compound	_	_
7	of	of	IN	IN	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	4	conj	_	_
9	3	3	CD	CD	_	8	nummod	_	_
10	)	)	-RRB-	-RRB-	_	4	punct	_	_
11	is	be	VBZ	VBZ	_	15	cop	_	_
12	a	a	DT	DT	_	15	det	_	_
13	latent	latent	JJ	JJ	_	15	amod	_	_
14	transcription	transcription	NN	NN	_	15	compound	_	_
15	factor	factor	NN	NN	_	0	root	_	_
16	that	that	WDT	WDT	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	activated	activate	VBN	VBN	_	15	acl:relcl	_	_
19	by	by	IN	IN	_	21	case	_	_
20	tyrosine	tyrosine	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	Tyr-705	tyr-705	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	in	in	IN	IN	_	26	case	_	_
26	cells	cell	NNS	NNS	_	18	nmod	_	_
27	stimulated	stimulate	VBN	VBN	_	26	acl	_	_
28	with	with	IN	IN	_	29	case	_	_
29	cytokines	cytokine	NNS	NNS	_	27	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	growth	growth	NN	NN	_	32	compound	_	_
32	factors	factor	NNS	NNS	_	29	conj	_	_
33	.	.	.	.	_	15	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	one	one	CD	CD	_	10	nummod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	more	more	JJR	JJR	_	5	conj	_	_
8	cytoplasmic	cytoplasmic	JJ	JJ	_	10	amod	_	_
9	serine	serine	NN	NN	_	10	compound	_	_
10	kinases	kinase	NNS	NNS	_	12	nsubj	_	_
11	also	also	RB	RB	_	12	advmod	_	_
12	phosphorylate	phosphorylate	VBP	VBP	_	3	ccomp	_	_
13	STAT3	stat3	NN	NN	_	12	dobj	_	_
14	and	and	CC	CC	_	12	cc	_	_
15	are	be	VBP	VBP	_	16	cop	_	_
16	necessary	necessary	JJ	JJ	_	12	conj	_	_
17	for	for	IN	IN	_	20	case	_	_
18	maximal	maximal	JJ	JJ	_	20	amod	_	_
19	gene	gene	NN	NN	_	20	compound	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	,	,	,	,	_	3	punct	_	_
5	with	with	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	site-specific	site-specific	JJ	JJ	_	8	amod	_	_
8	antibody	antibody	NN	NN	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	STAT3	stat3	NN	NN	_	13	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	13	auxpass	_	_
13	phosphorylated	phosphorylate	VBN	VBN	_	3	ccomp	_	_
14	on	on	IN	IN	_	15	case	_	_
15	Ser-727	ser-727	NN	NN	_	13	nmod	_	_
16	in	in	IN	IN	_	18	case	_	_
17	human	human	JJ	JJ	_	18	amod	_	_
18	neutrophils	neutrophil	NNS	NNS	_	13	nmod	_	_
19	stimulated	stimulate	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	22	case	_	_
21	chemotactic	chemotactic	JJ	JJ	_	22	amod	_	_
22	factors	factor	NNS	NNS	_	19	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	N-formyl-methionyl-leucyl-phenylalanine	n-formyl-methionyl-leucyl-phenylalanine	NN	NN	_	22	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	complement	complement	NN	NN	_	27	compound	_	_
27	C5a	c5a	NN	NN	_	24	conj	_	_
28	)	)	-RRB-	-RRB-	_	24	punct	_	_
29	,	,	,	,	_	22	punct	_	_
30	cytokines	cytokine	NNS	NNS	_	22	conj	_	_
31	-LSB-	-lsb-	-LRB-	-LRB-	_	34	punct	_	_
32	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	34	amod	_	_
33	colony-stimulating	colony-stimulating	JJ	JJ	_	34	amod	_	_
34	factor	factor	NN	NN	_	30	dep	_	_
35	(	(	-LRB-	-LRB-	_	36	punct	_	_
36	GM-CSF	gm-csf	NN	NN	_	34	appos	_	_
37	)	)	-RRB-	-RRB-	_	36	punct	_	_
38	and	and	CC	CC	_	34	cc	_	_
39	granulocyte	granulocyte	NN	NN	_	41	compound	_	_
40	colony-stimulating	colony-stimulating	JJ	JJ	_	41	amod	_	_
41	factor	factor	NN	NN	_	34	conj	_	_
42	(	(	-LRB-	-LRB-	_	43	punct	_	_
43	G-CSF	g-csf	NN	NN	_	41	appos	_	_
44	)	)	-RRB-	-RRB-	_	43	punct	_	_
45	-RSB-	-rsb-	-RRB-	-RRB-	_	34	punct	_	_
46	,	,	,	,	_	22	punct	_	_
47	or	or	CC	CC	_	22	cc	_	_
48	a	a	DT	DT	_	52	det	_	_
49	protein	protein	NN	NN	_	52	compound	_	_
50	kinase	kinase	NN	NN	_	52	compound	_	_
51	C	c	NN	NN	_	52	compound	_	_
52	activator	activator	NN	NN	_	22	conj	_	_
53	(	(	-LRB-	-LRB-	_	54	punct	_	_
54	PMA	pma	NN	NN	_	52	appos	_	_
55	)	)	-RRB-	-RRB-	_	54	punct	_	_
56	.	.	.	.	_	3	punct	_	_

1	(2-Amino-3'-methoxyphenyl)oxanaphthalen-4-one	(2-amino-3'-methoxyphenyl)oxanaphthalen-4-one	NN	NN	_	19	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	PD	pd	NN	NN	_	1	appos	_	_
4	98059	98059	CD	CD	_	3	nummod	_	_
5	)	)	-RRB-	-RRB-	_	3	punct	_	_
6	,	,	,	,	_	1	punct	_	_
7	an	a	DT	DT	_	8	det	_	_
8	inhibitor	inhibitor	NN	NN	_	1	appos	_	_
9	of	of	IN	IN	_	17	case	_	_
10	extracellular	extracellular	JJ	JJ	_	17	amod	_	_
11	signal-regulated	signal-regulated	JJ	JJ	_	17	amod	_	_
12	protein	protein	NN	NN	_	17	compound	_	_
13	kinase	kinase	NN	NN	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	ERK	erk	NN	NN	_	17	compound	_	_
16	)	)	-RRB-	-RRB-	_	17	punct	_	_
17	activation	activation	NN	NN	_	8	nmod	_	_
18	,	,	,	,	_	1	punct	_	_
19	blocked	block	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	22	det	_	_
21	serine	serine	JJ	JJ	_	22	amod	_	_
22	phosphorylation	phosphorylation	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	STAT3	stat3	NN	NN	_	22	nmod	_	_
25	induced	induce	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	chemotactic	chemotactic	JJ	JJ	_	28	amod	_	_
28	factors	factor	NNS	NNS	_	25	nmod	_	_
29	or	or	CC	CC	_	28	cc	_	_
30	PMA	pma	NN	NN	_	28	conj	_	_
31	.	.	.	.	_	19	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	drug	drug	NN	NN	_	5	nsubj	_	_
3	was	be	VBD	VBD	_	5	cop	_	_
4	less	less	JJR	JJR	_	5	dep	_	_
5	effective	effective	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	7	case	_	_
7	cytokines	cytokine	NNS	NNS	_	5	nmod	_	_
8	:	:	:	:	_	5	punct	_	_
9	it	it	PRP	PRP	_	11	nsubj	_	_
10	virtually	virtually	RB	RB	_	11	advmod	_	_
11	abolished	abolish	VBD	VBD	_	5	parataxis	_	_
12	the	the	DT	DT	_	13	det	_	_
13	response	response	NN	NN	_	11	dobj	_	_
14	to	to	TO	TO	_	15	case	_	_
15	GM-CSF	gm-csf	NN	NN	_	13	nmod	_	_
16	that	that	WDT	WDT	_	17	nsubj	_	_
17	occurred	occur	VBD	VBD	_	15	acl:relcl	_	_
18	5	5	CD	CD	_	19	nummod	_	_
19	min	min	NN	NN	_	17	dobj	_	_
20	after	after	IN	IN	_	21	case	_	_
21	stimulation	stimulation	NN	NN	_	19	nmod	_	_
22	but	but	CC	CC	_	11	cc	_	_
23	only	only	RB	RB	_	24	advmod	_	_
24	partly	partly	RB	RB	_	25	advmod	_	_
25	decreased	decrease	VBD	VBD	_	11	conj	_	_
26	those	those	DT	DT	_	25	dobj	_	_
27	at	at	IN	IN	_	29	case	_	_
28	15-30	15-30	CD	CD	_	29	nummod	_	_
29	min	min	NN	NN	_	25	nmod	_	_
30	and	and	CC	CC	_	25	cc	_	_
31	did	do	VBD	VBD	_	34	aux	_	_
32	not	not	RB	RB	_	34	neg	_	_
33	appreciably	appreciably	RB	RB	_	34	advmod	_	_
34	alter	alter	VB	VB	_	25	conj	_	_
35	responses	response	NNS	NNS	_	34	dobj	_	_
36	to	to	TO	TO	_	37	case	_	_
37	G-CSF	g-csf	NN	NN	_	35	nmod	_	_
38	regardless	regardless	RB	RB	_	41	advmod	_	_
39	of	of	IN	IN	_	41	case	_	_
40	incubation	incubation	NN	NN	_	41	compound	_	_
41	time	time	NN	NN	_	34	advcl	_	_
42	.	.	.	.	_	5	punct	_	_

1	1-(5-Isoquinolinylsulphonyl)-2-methylpiperazine	1-(5-isoquinolinylsulphonyl)-2-methylpiperazine	NN	NN	_	2	compound	_	_
2	dihydrochloride	dihydrochloride	NN	NN	_	36	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	H7	h7	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	,	,	,	,	_	2	punct	_	_
7	an	a	DT	DT	_	8	det	_	_
8	inhibitor	inhibitor	NN	NN	_	2	appos	_	_
9	of	of	IN	IN	_	14	case	_	_
10	a	a	DT	DT	_	14	det	_	_
11	putative	putative	JJ	JJ	_	14	amod	_	_
12	STAT3	stat3	NN	NN	_	14	compound	_	_
13	serine	serine	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	2	punct	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	4-(4-fluorophenyl)-2-(4-methylsulphinylphenyl)-5-(4-pyridyl)1H-imidazole	4-(4-fluorophenyl)-2-(4-methylsulphinylphenyl)-5-(4-pyridyl)1h-imidazole	NN	NN	_	2	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	SB	sb	NN	NN	_	17	appos	_	_
20	203580	203580	CD	CD	_	19	nummod	_	_
21	)	)	-RRB-	-RRB-	_	19	punct	_	_
22	,	,	,	,	_	17	punct	_	_
23	an	a	DT	DT	_	24	det	_	_
24	inhibitor	inhibitor	NN	NN	_	17	appos	_	_
25	of	of	IN	IN	_	32	case	_	_
26	p38	p38	NN	NN	_	32	compound	_	_
27	mitogen-activated	mitogen-activated	JJ	JJ	_	32	amod	_	_
28	protein	protein	NN	NN	_	32	compound	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	MAP	map	NN	NN	_	32	compound	_	_
31	)	)	-RRB-	-RRB-	_	32	punct	_	_
32	kinase	kinase	NN	NN	_	24	nmod	_	_
33	,	,	,	,	_	17	punct	_	_
34	did	do	VBD	VBD	_	36	aux	_	_
35	not	not	RB	RB	_	36	neg	_	_
36	dampen	dampen	VB	VB	_	0	root	_	_
37	any	any	DT	DT	_	36	dobj	_	_
38	of	of	IN	IN	_	42	case	_	_
39	these	these	DT	DT	_	42	det	_	_
40	serine	serine	NN	NN	_	42	compound	_	_
41	phosphorylation	phosphorylation	NN	NN	_	42	compound	_	_
42	responses	response	NNS	NNS	_	37	nmod	_	_
43	.	.	.	.	_	36	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	propose	propose	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	5	mark	_	_
4	neutrophils	neutrophil	NNS	NNS	_	5	nsubj	_	_
5	use	use	VBP	VBP	_	2	ccomp	_	_
6	both	both	CC	CC	_	7	cc:preconj	_	_
7	ERK-dependent	erk-dependent	JJ	JJ	_	5	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	ERK-independent	erk-independent	JJ	JJ	_	7	conj	_	_
10	pathways	pathway	NNS	NNS	_	7	dep	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	phosphorylate	phosphorylate	VB	VB	_	5	advcl	_	_
13	Ser-727	ser-727	NN	NN	_	12	dobj	_	_
14	on	on	IN	IN	_	15	case	_	_
15	STAT3	stat3	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	former	former	JJ	JJ	_	3	amod	_	_
3	pathway	pathway	NN	NN	_	5	nsubjpass	_	_
4	is	be	VBZ	VBZ	_	5	auxpass	_	_
5	recruited	recruit	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	all	all	DT	DT	_	9	det	_	_
8	ERK-activating	erk-activating	JJ	JJ	_	9	amod	_	_
9	stimuli	stimulus	NNS	NNS	_	5	nmod	_	_
10	,	,	,	,	_	5	punct	_	_
11	whereas	whereas	IN	IN	_	5	dep	_	_
12	the	the	DT	DT	_	14	det	_	_
13	latter	latter	JJ	JJ	_	14	amod	_	_
14	pathway	pathway	NN	NN	_	15	nsubj	_	_
15	uses	use	VBZ	VBZ	_	5	parataxis	_	_
16	an	a	DT	DT	_	19	det	_	_
17	undefined	undefined	JJ	JJ	_	19	amod	_	_
18	serine	serine	NN	NN	_	19	compound	_	_
19	kinase	kinase	NN	NN	_	15	dobj	_	_
20	and	and	CC	CC	_	15	cc	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	recruited	recruit	VBN	VBN	_	15	conj	_	_
23	selectively	selectively	RB	RB	_	22	advmod	_	_
24	by	by	IN	IN	_	25	case	_	_
25	cytokines	cytokine	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	STAT5	stat5	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	5	case	_	_
5	IL-4	il-4	NN	NN	_	1	nmod	_	_
6	relies	rely	VBZ	VBZ	_	0	root	_	_
7	on	on	IN	IN	_	10	case	_	_
8	Janus	janus	NN	NN	_	10	compound	_	_
9	kinase	kinase	NN	NN	_	10	compound	_	_
10	function	function	NN	NN	_	6	nmod	_	_
11	but	but	CC	CC	_	10	cc	_	_
12	not	not	RB	RB	_	16	neg	_	_
13	on	on	IN	IN	_	16	case	_	_
14	receptor	receptor	NN	NN	_	16	compound	_	_
15	tyrosine	tyrosine	NN	NN	_	16	compound	_	_
16	phosphorylation	phosphorylation	NN	NN	_	10	conj	_	_
17	,	,	,	,	_	6	punct	_	_
18	and	and	CC	CC	_	6	cc	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	contribute	contribute	VB	VB	_	6	conj	_	_
21	to	to	TO	TO	_	24	case	_	_
22	both	both	CC	CC	_	24	cc:preconj	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	proliferation	proliferation	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	gene	gene	NN	NN	_	27	compound	_	_
27	regulation	regulation	NN	NN	_	24	conj	_	_
28	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	investigated	investigate	VBN	VBN	_	0	root	_	_
4	mechanisms	mechanism	NNS	NNS	_	3	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	consequences	consequence	NNS	NNS	_	4	conj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	STAT5	stat5	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	4	nmod	_	_
10	through	through	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	IL-4	il-4	NN	NN	_	14	compound	_	_
14	receptor	receptor	NN	NN	_	3	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-4R	il-4r	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	3	punct	_	_

1	By	by	IN	IN	_	3	mark	_	_
2	functionally	functionally	RB	RB	_	3	advmod	_	_
3	expressing	express	VBG	VBG	_	16	advcl	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	mutants	mutant	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	murine	murine	JJ	JJ	_	11	amod	_	_
9	pro-B	pro-b	JJ	JJ	_	11	amod	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	line	line	NN	NN	_	5	nmod	_	_
12	Ba/F3	ba/f3	NN	NN	_	11	dep	_	_
13	,	,	,	,	_	16	punct	_	_
14	we	we	PRP	PRP	_	16	nsubj	_	_
15	could	could	MD	MD	_	16	aux	_	_
16	show	show	VB	VB	_	0	root	_	_
17	that	that	IN	IN	_	27	mark	_	_
18	phosphorylated	phosphorylate	VBN	VBN	_	20	amod	_	_
19	tyrosine	tyrosine	NN	NN	_	20	compound	_	_
20	residues	residue	NNS	NNS	_	27	nsubj	_	_
21	within	within	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	IL-4R	il-4r	NN	NN	_	25	compound	_	_
24	alpha	alpha	NN	NN	_	25	compound	_	_
25	chain	chain	NN	NN	_	20	nmod	_	_
26	are	be	VBP	VBP	_	27	cop	_	_
27	dispensable	dispensable	JJ	JJ	_	16	ccomp	_	_
28	for	for	IN	IN	_	31	case	_	_
29	IL-4-induced	il-4-induced	JJ	JJ	_	31	amod	_	_
30	STAT5	stat5	NN	NN	_	31	compound	_	_
31	activity	activity	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	disruption	disruption	NN	NN	_	22	nsubj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	membrane-proximal	membrane-proximal	JJ	JJ	_	9	amod	_	_
7	proline-rich	proline-rich	JJ	JJ	_	9	amod	_	_
8	sequence	sequence	NN	NN	_	9	compound	_	_
9	motif	motif	NN	NN	_	3	nmod	_	_
10	(	(	-LRB-	-LRB-	_	12	punct	_	_
11	'	'	``	``	_	12	punct	_	_
12	box1	box1	NN	NN	_	9	appos	_	_
13	'	'	''	''	_	12	punct	_	_
14	)	)	-RRB-	-RRB-	_	12	punct	_	_
15	in	in	IN	IN	_	17	case	_	_
16	either	either	DT	DT	_	17	det	_	_
17	subunit	subunit	NN	NN	_	3	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	bipartite	bipartite	JJ	JJ	_	21	amod	_	_
21	IL-4R	il-4r	NN	NN	_	17	nmod	_	_
22	abolished	abolish	VBD	VBD	_	0	root	_	_
23	not	not	RB	RB	_	27	neg	_	_
24	only	only	RB	RB	_	27	advmod	_	_
25	ligand-induced	ligand-induced	JJ	JJ	_	27	amod	_	_
26	tyrosine	tyrosine	NN	NN	_	27	compound	_	_
27	phosphorylation	phosphorylation	NN	NN	_	22	dobj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	Janus	janus	NN	NN	_	30	compound	_	_
30	kinases	kinase	NNS	NNS	_	27	nmod	_	_
31	JAK1	jak1	NN	NN	_	30	dep	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	JAK3	jak3	NN	NN	_	31	conj	_	_
34	,	,	,	,	_	27	punct	_	_
35	but	but	CC	CC	_	27	cc	_	_
36	also	also	RB	RB	_	27	advmod	_	_
37	IL-4-triggered	il-4-triggered	JJ	JJ	_	38	amod	_	_
38	activation	activation	NN	NN	_	27	dep	_	_
39	of	of	IN	IN	_	40	case	_	_
40	STAT5	stat5	NN	NN	_	38	nmod	_	_
41	and	and	CC	CC	_	38	cc	_	_
42	concomitant	concomitant	JJ	JJ	_	44	amod	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	proliferation	proliferation	NN	NN	_	38	conj	_	_
45	.	.	.	.	_	22	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	dominant-negative	dominant-negative	JJ	JJ	_	3	amod	_	_
3	version	version	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	STAT5b	stat5b	NN	NN	_	3	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	5	cc	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT5a	stat5a	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	12	punct	_	_
12	interfered	interfere	VBD	VBD	_	0	root	_	_
13	with	with	IN	IN	_	16	case	_	_
14	IL-4-induced	il-4-induced	JJ	JJ	_	16	amod	_	_
15	DNA	dna	NN	NN	_	16	compound	_	_
16	synthesis	synthesis	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	Ba/F3	ba/f3	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	,	,	,	,	_	12	punct	_	_
21	suggesting	suggest	VBG	VBG	_	12	xcomp	_	_
22	an	a	DT	DT	_	23	det	_	_
23	involvement	involvement	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	STAT5b	stat5b	NN	NN	_	23	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	control	control	NN	NN	_	23	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	proliferation	proliferation	NN	NN	_	28	nmod	_	_
32	through	through	IN	IN	_	33	case	_	_
33	IL-4R	il-4r	NN	NN	_	23	nmod	_	_
34	.	.	.	.	_	12	punct	_	_

1	Reporter	reporter	NN	NN	_	3	compound	_	_
2	gene	gene	NN	NN	_	3	compound	_	_
3	experiments	experiment	NNS	NNS	_	5	nsubj	_	_
4	finally	finally	RB	RB	_	5	advmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	17	mark	_	_
7	transcription	transcription	NN	NN	_	17	nsubjpass	_	_
8	from	from	IN	IN	_	9	case	_	_
9	promoters	promoter	NNS	NNS	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	STAT5	stat5	NN	NN	_	13	compound	_	_
12	target	target	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	9	nmod	_	_
14	can	can	MD	MD	_	17	aux	_	_
15	be	be	VB	VB	_	17	auxpass	_	_
16	specifically	specifically	RB	RB	_	17	advmod	_	_
17	induced	induce	VBN	VBN	_	5	ccomp	_	_
18	by	by	IN	IN	_	20	case	_	_
19	challenging	challenge	VBG	VBG	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	IL-4	il-4	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	17	punct	_	_
24	and	and	CC	CC	_	17	cc	_	_
25	that	that	IN	IN	_	31	mark	_	_
26	both	both	CC	CC	_	27	cc:preconj	_	_
27	STAT5a	stat5a	NN	NN	_	31	nsubj	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	STAT5b	stat5b	NN	NN	_	27	conj	_	_
30	can	can	MD	MD	_	31	aux	_	_
31	contribute	contribute	VB	VB	_	17	conj	_	_
32	to	to	TO	TO	_	35	case	_	_
33	IL-4-triggered	il-4-triggered	JJ	JJ	_	35	amod	_	_
34	transcriptional	transcriptional	JJ	JJ	_	35	amod	_	_
35	control	control	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Stimulation	stimulation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	neutrophil	neutrophil	NN	NN	_	1	nmod	_	_
4	interleukin-8	interleukin-8	NN	NN	_	5	compound	_	_
5	production	production	NN	NN	_	3	dep	_	_
6	by	by	IN	IN	_	11	case	_	_
7	eosinophil	eosinophil	NN	NN	_	11	compound	_	_
8	granule	granule	NN	NN	_	11	compound	_	_
9	major	major	JJ	JJ	_	11	amod	_	_
10	basic	basic	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	1	nmod	_	_
12	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	evaluated	evaluate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	ability	ability	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	eosinophil	eosinophil	NN	NN	_	7	compound	_	_
7	granule	granule	NN	NN	_	4	nmod	_	_
8	major	major	JJ	JJ	_	10	amod	_	_
9	basic	basic	JJ	JJ	_	10	amod	_	_
10	protein	protein	NN	NN	_	7	dep	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MBP	mbp	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	stimulate	stimulate	VB	VB	_	4	acl	_	_
16	interleukin	interleukin	NN	NN	_	21	compound	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	IL	il	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	-8	-8	CD	CD	_	21	nummod	_	_
21	production	production	NN	NN	_	15	dobj	_	_
22	by	by	IN	IN	_	23	case	_	_
23	neutrophils	neutrophil	NNS	NNS	_	15	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	MBP	mbp	NN	NN	_	11	nsubj	_	_
2	over	over	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	concentration	concentration	NN	NN	_	5	compound	_	_
5	range	range	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	10	case	_	_
7	0.1	0.1	CD	CD	_	9	compound	_	_
8	to	to	TO	TO	_	9	dep	_	_
9	10	10	CD	CD	_	10	nummod	_	_
10	microM	microm	NN	NN	_	5	nmod	_	_
11	stimulated	stimulate	VBD	VBD	_	0	root	_	_
12	the	the	DT	DT	_	13	det	_	_
13	release	release	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	20	case	_	_
15	up	up	RB	RB	_	18	advmod	_	_
16	to	to	TO	TO	_	18	dep	_	_
17	approximately	approximately	RB	RB	_	18	advmod	_	_
18	8	8	CD	CD	_	20	nummod	_	_
19	ng/ml	ng/ml	NN	NN	_	20	compound	_	_
20	IL-8	il-8	NN	NN	_	13	nmod	_	_
21	.	.	.	.	_	11	punct	_	_

1	Incubation	incubation	NN	NN	_	6	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	2	2	CD	CD	_	5	nummod	_	_
4	microM	microm	NN	NN	_	5	compound	_	_
5	MBP	mbp	NN	NN	_	1	nmod	_	_
6	showed	show	VBD	VBD	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	,	,	,	,	_	20	punct	_	_
9	after	after	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	1	1	CD	CD	_	13	nummod	_	_
12	h	h	NN	NN	_	13	compound	_	_
13	lag	lag	NN	NN	_	20	nmod	_	_
14	,	,	,	,	_	20	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	level	level	NN	NN	_	20	nsubj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	IL-8	il-8	NN	NN	_	19	compound	_	_
19	release	release	NN	NN	_	16	nmod	_	_
20	increased	increase	VBD	VBD	_	6	ccomp	_	_
21	with	with	IN	IN	_	22	case	_	_
22	time	time	NN	NN	_	20	nmod	_	_
23	for	for	IN	IN	_	26	case	_	_
24	approximately	approximately	RB	RB	_	25	advmod	_	_
25	10	10	CD	CD	_	26	nummod	_	_
26	h	h	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	At	at	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	2	2	CD	CD	_	5	nummod	_	_
4	microM	microm	NN	NN	_	5	compound	_	_
5	concentration	concentration	NN	NN	_	19	nmod	_	_
6	,	,	,	,	_	19	punct	_	_
7	eosinophil	eosinophil	NN	NN	_	9	compound	_	_
8	cationic	cationic	NN	NN	_	9	compound	_	_
9	protein	protein	NN	NN	_	19	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	eosinophil-derived	eosinophil-derived	JJ	JJ	_	12	amod	_	_
12	neurotoxin	neurotoxin	NN	NN	_	9	conj	_	_
13	,	,	,	,	_	9	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	eosinophil	eosinophil	NN	NN	_	16	compound	_	_
16	peroxidase	peroxidase	NN	NN	_	9	conj	_	_
17	did	do	VBD	VBD	_	19	aux	_	_
18	not	not	RB	RB	_	19	neg	_	_
19	stimulate	stimulate	VB	VB	_	0	root	_	_
20	significant	significant	JJ	JJ	_	21	amod	_	_
21	levels	level	NNS	NNS	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	IL-8	il-8	NN	NN	_	24	compound	_	_
24	production	production	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	19	punct	_	_

1	MBP	mbp	NN	NN	_	2	nsubj	_	_
2	stimulated	stimulate	VBD	VBD	_	0	root	_	_
3	2-fold	2-fold	JJ	JJ	_	4	amod	_	_
4	increases	increase	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	6	case	_	_
6	IL-8	il-8	NN	NN	_	4	nmod	_	_
7	messenger	messenger	NN	NN	_	8	compound	_	_
8	RNA	rna	NN	NN	_	6	dep	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	mRNA	mrna	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	after	after	IN	IN	_	16	case	_	_
13	1	1	CD	CD	_	16	compound	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	3	3	CD	CD	_	13	conj	_	_
16	h	h	NN	NN	_	4	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	incubation	incubation	NN	NN	_	16	nmod	_	_
19	,	,	,	,	_	4	punct	_	_
20	which	which	WDT	WDT	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	blocked	block	VBN	VBN	_	4	acl:relcl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	pretreatment	pretreatment	NN	NN	_	22	nmod	_	_
25	with	with	IN	IN	_	27	case	_	_
26	actinomycin	actinomycin	NN	NN	_	27	compound	_	_
27	D	d	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	2	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	stimulation	stimulation	NN	NN	_	8	nsubj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	MBP	mbp	NN	NN	_	3	nmod	_	_
6	did	do	VBD	VBD	_	8	aux	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	produce	produce	VB	VB	_	0	root	_	_
9	an	a	DT	DT	_	10	det	_	_
10	increase	increase	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	binding	binding	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	21	case	_	_
16	nuclear	nuclear	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	21	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	NF	nf	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	-kappaB	-kappab	NN	NN	_	14	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	activator	activator	NN	NN	_	24	compound	_	_
24	protein-1	protein-1	NN	NN	_	21	conj	_	_
25	.	.	.	.	_	8	punct	_	_

1	No	no	DT	DT	_	4	neg	_	_
2	NF-IL-6	nf-il-6	NN	NN	_	4	compound	_	_
3	binding	binding	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	detected	detect	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	same	same	JJ	JJ	_	11	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	extracts	extract	NNS	NNS	_	6	nmod	_	_
12	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
5	with	with	IN	IN	_	6	case	_	_
6	MBP	mbp	NN	NN	_	4	nmod	_	_
7	prolonged	prolong	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	stability	stability	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-8	il-8	NN	NN	_	12	compound	_	_
12	mRNA	mrna	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	MBP	mbp	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	induced	induce	VBD	VBD	_	0	root	_	_
4	transient	transient	JJ	JJ	_	5	amod	_	_
5	increases	increase	NNS	NNS	_	3	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	mRNA	mrna	NN	NN	_	5	nmod	_	_
8	for	for	IN	IN	_	15	case	_	_
9	macrophage	macrophage	NN	NN	_	11	compound	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	protein	protein	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	MIP	mip	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	-1alpha	-1alpha	NN	NN	_	5	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	MIP-1beta	mip-1beta	NN	NN	_	15	conj	_	_
18	,	,	,	,	_	3	punct	_	_
19	but	but	CC	CC	_	3	cc	_	_
20	did	do	VBD	VBD	_	22	aux	_	_
21	not	not	RB	RB	_	22	neg	_	_
22	stimulate	stimulate	VB	VB	_	3	conj	_	_
23	the	the	DT	DT	_	24	det	_	_
24	release	release	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	either	either	DT	DT	_	27	det	_	_
27	chemokine	chemokine	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	MBP	mbp	NN	NN	_	7	nsubj	_	_
6	is	be	VBZ	VBZ	_	7	cop	_	_
7	selective	selective	JJ	JJ	_	3	ccomp	_	_
8	among	among	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	eosinophil	eosinophil	NN	NN	_	12	compound	_	_
11	granule	granule	NN	NN	_	12	compound	_	_
12	proteins	protein	NNS	NNS	_	7	nmod	_	_
13	as	as	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	stimulus	stimulus	NN	NN	_	7	nmod	_	_
16	for	for	IN	IN	_	19	case	_	_
17	neutrophil	neutrophil	NN	NN	_	19	compound	_	_
18	IL-8	il-8	NN	NN	_	19	compound	_	_
19	release	release	NN	NN	_	15	nmod	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	,	,	,	,	_	7	punct	_	_
22	further	further	RB	RB	_	7	advmod	_	_
23	,	,	,	,	_	7	punct	_	_
24	that	that	IN	IN	_	32	mark	_	_
25	stimulation	stimulation	NN	NN	_	32	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	neutrophil	neutrophil	NN	NN	_	29	compound	_	_
28	IL-8	il-8	NN	NN	_	29	compound	_	_
29	release	release	NN	NN	_	25	nmod	_	_
30	by	by	IN	IN	_	31	case	_	_
31	MBP	mbp	NN	NN	_	25	nmod	_	_
32	involves	involve	VBZ	VBZ	_	7	dep	_	_
33	both	both	CC	CC	_	34	cc:preconj	_	_
34	transcriptional	transcriptional	JJ	JJ	_	37	amod	_	_
35	and	and	CC	CC	_	34	cc	_	_
36	posttranscriptional	posttranscriptional	JJ	JJ	_	34	conj	_	_
37	regulation	regulation	NN	NN	_	32	dobj	_	_
38	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	postulate	postulate	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	11	mark	_	_
4	MBP-induced	mbp-induced	JJ	JJ	_	5	amod	_	_
5	release	release	NN	NN	_	11	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IL-8	il-8	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	case	_	_
9	neutrophils	neutrophil	NNS	NNS	_	5	nmod	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	contribute	contribute	VB	VB	_	2	ccomp	_	_
12	to	to	TO	TO	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	pathophysiology	pathophysiology	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	17	case	_	_
16	acute	acute	JJ	JJ	_	17	amod	_	_
17	asthma	asthma	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	other	other	JJ	JJ	_	22	amod	_	_
20	inflammatory	inflammatory	JJ	JJ	_	22	amod	_	_
21	lung	lung	NN	NN	_	22	compound	_	_
22	diseases	disease	NNS	NNS	_	17	conj	_	_
23	.	.	.	.	_	2	punct	_	_

1	PPARgamma	ppargamma	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	expression	expression	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	13	case	_	_
7	the	the	DT	DT	_	13	det	_	_
8	adipocyte	adipocyte	NN	NN	_	13	compound	_	_
9	fatty	fatty	JJ	JJ	_	13	amod	_	_
10	acid	acid	NN	NN	_	13	compound	_	_
11	binding	binding	NN	NN	_	13	compound	_	_
12	protein	protein	NN	NN	_	13	compound	_	_
13	gene	gene	NN	NN	_	5	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	monocytes	monocyte	NNS	NNS	_	13	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	peroxisome-proliferator	peroxisome-proliferator	NN	NN	_	5	compound	_	_
3	activated	activated	JJ	JJ	_	5	amod	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	gamma	gamma	NN	NN	_	23	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	PPARgamma	ppargamma	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	a	a	DT	DT	_	11	det	_	_
11	member	member	NN	NN	_	5	appos	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	nuclear	nuclear	JJ	JJ	_	16	amod	_	_
15	receptor	receptor	NN	NN	_	16	compound	_	_
16	superfamily	superfamily	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	21	case	_	_
18	ligand	ligand	NN	NN	_	21	compound	_	_
19	activated	activated	JJ	JJ	_	21	amod	_	_
20	transcription	transcription	NN	NN	_	21	compound	_	_
21	factors	factor	NNS	NNS	_	16	nmod	_	_
22	,	,	,	,	_	23	punct	_	_
23	plays	play	VBZ	VBZ	_	0	root	_	_
24	a	a	DT	DT	_	26	det	_	_
25	key	key	JJ	JJ	_	26	amod	_	_
26	role	role	NN	NN	_	23	dobj	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	anti-diabetic	anti-diabetic	JJ	JJ	_	30	amod	_	_
30	actions	action	NNS	NNS	_	26	nmod	_	_
31	of	of	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	thiazolidinediones	thiazolidinedione	NNS	NNS	_	30	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	TZDs	tzd	NNS	NNS	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	23	punct	_	_

1	PPARgamma	ppargamma	NN	NN	_	2	nsubj	_	_
2	induces	induce	VBZ	VBZ	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	many	many	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	4	nmod	_	_
8	involved	involve	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	lipid	lipid	NN	NN	_	11	compound	_	_
11	anabolism	anabolism	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	including	include	VBG	VBG	_	19	case	_	_
14	the	the	DT	DT	_	19	det	_	_
15	adipocyte	adipocyte	NN	NN	_	19	compound	_	_
16	fatty	fatty	JJ	JJ	_	19	amod	_	_
17	acid	acid	NN	NN	_	19	compound	_	_
18	binding	binding	NN	NN	_	19	compound	_	_
19	protein	protein	NN	NN	_	7	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	aP2	ap2	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	2	punct	_	_
24	and	and	CC	CC	_	2	cc	_	_
25	is	be	VBZ	VBZ	_	28	cop	_	_
26	a	a	DT	DT	_	28	det	_	_
27	key	key	JJ	JJ	_	28	amod	_	_
28	regulator	regulator	NN	NN	_	2	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	adipocyte	adipocyte	JJ	JJ	_	31	amod	_	_
31	differentiation	differentiation	NN	NN	_	28	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	PPARgamma	ppargamma	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	expressed	express	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	hematopoietic	hematopoietic	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	up-regulated	up-regulate	VBN	VBN	_	4	conj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	activated	activate	VBN	VBN	_	13	amod	_	_
13	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PPARgamma	ppargamma	NN	NN	_	1	nmod	_	_
4	may	may	MD	MD	_	5	aux	_	_
5	play	play	VB	VB	_	0	root	_	_
6	a	a	DT	DT	_	7	det	_	_
7	role	role	NN	NN	_	5	dobj	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	induction	induction	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	differentiation	differentiation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	macrophages	macrophage	NNS	NNS	_	12	nmod	_	_
15	to	to	TO	TO	_	14	dep	_	_
16	foam	foam	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	dep	_	_
18	that	that	WDT	WDT	_	20	nsubjpass	_	_
19	are	be	VBP	VBP	_	20	auxpass	_	_
20	associated	associate	VBN	VBN	_	17	acl:relcl	_	_
21	with	with	IN	IN	_	23	case	_	_
22	atherosclerotic	atherosclerotic	JJ	JJ	_	23	amod	_	_
23	lesions	lesion	NNS	NNS	_	20	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	report	report	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	10	mark	_	_
4	both	both	CC	CC	_	5	cc:preconj	_	_
5	natural	natural	JJ	JJ	_	9	amod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	synthetic	synthetic	JJ	JJ	_	5	conj	_	_
8	PPARgamma	ppargamma	NN	NN	_	9	compound	_	_
9	agonists	agonist	NNS	NNS	_	10	nsubj	_	_
10	induce	induce	VBP	VBP	_	2	ccomp	_	_
11	time-	time-	NN	NN	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	dose-dependent	dose-dependent	JJ	JJ	_	11	conj	_	_
14	increases	increase	NNS	NNS	_	10	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	aP2	ap2	NN	NN	_	17	compound	_	_
17	mRNA	mrna	NN	NN	_	14	nmod	_	_
18	in	in	IN	IN	_	22	case	_	_
19	both	both	CC	CC	_	22	cc:preconj	_	_
20	primary	primary	JJ	JJ	_	22	amod	_	_
21	human	human	JJ	JJ	_	22	amod	_	_
22	monocytes	monocyte	NNS	NNS	_	17	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	the	the	DT	DT	_	22	conj	_	_
25	monocytic	monocytic	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	line	line	NN	NN	_	22	dep	_	_
28	,	,	,	,	_	27	punct	_	_
29	THP-1	thp-1	NN	NN	_	27	appos	_	_
30	.	.	.	.	_	2	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	PPARgamma	ppargamma	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	play	play	VB	VB	_	3	ccomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	monocyte	monocyte	NN	NN	_	13	compound	_	_
13	differentiation	differentiation	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	function	function	VB	VB	_	13	conj	_	_
16	analogous	analogous	JJ	JJ	_	10	amod	_	_
17	to	to	TO	TO	_	20	case	_	_
18	its	its	PRP$	PRP$	_	20	nmod:poss	_	_
19	well-characterized	well-characterized	JJ	JJ	_	20	amod	_	_
20	role	role	NN	NN	_	16	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	adipocytes	adipocyte	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Reactive	reactive	JJ	JJ	_	3	amod	_	_
2	oxygen	oxygen	NN	NN	_	3	compound	_	_
3	intermediate-release	intermediate-release	NN	NN	_	7	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	fibre-exposed	fibre-exposed	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
7	increases	increase	VBZ	VBZ	_	0	root	_	_
8	inflammatory	inflammatory	JJ	JJ	_	10	amod	_	_
9	cytokine-mRNA	cytokine-mrna	JJ	JJ	_	10	amod	_	_
10	level	level	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	protein	protein	NN	NN	_	14	compound	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	kinase	kinase	NN	NN	_	10	conj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	10	conj	_	_
18	in	in	IN	IN	_	22	case	_	_
19	co-cultured	co-culture	VBN	VBN	_	22	amod	_	_
20	bronchial	bronchial	JJ	JJ	_	22	amod	_	_
21	epithelial	epithelial	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	10	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	BEAS-2B	beas-2b	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	7	punct	_	_

1	Some	some	DT	DT	_	3	det	_	_
2	pulmonary	pulmonary	JJ	JJ	_	3	amod	_	_
3	diseases	disease	NNS	NNS	_	10	nsubjpass	_	_
4	like	like	IN	IN	_	5	case	_	_
5	bronchitis	bronchitis	NN	NN	_	3	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	asthma	asthma	NN	NN	_	8	compound	_	_
8	bronchiale	bronchiale	NN	NN	_	5	conj	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	mediated	mediate	VBN	VBN	_	0	root	_	_
11	by	by	IN	IN	_	13	case	_	_
12	inflammatory	inflammatory	JJ	JJ	_	13	amod	_	_
13	mechanisms	mechanism	NNS	NNS	_	10	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	bronchial	bronchial	JJ	JJ	_	17	amod	_	_
16	epithelial	epithelial	JJ	JJ	_	17	amod	_	_
17	cells	cell	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	10	punct	_	_

1	Alveolar	alveolar	JJ	JJ	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	aux	_	_
4	located	located	JJ	JJ	_	0	root	_	_
5	directly	directly	RB	RB	_	4	advmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	surrounding	surrounding	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	these	these	DT	DT	_	11	det	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	so	so	IN	IN	_	4	dep	_	_
14	that	that	IN	IN	_	4	dep	_	_
15	we	we	PRP	PRP	_	16	nsubj	_	_
16	suppose	suppose	VBP	VBP	_	4	parataxis	_	_
17	an	a	DT	DT	_	18	det	_	_
18	interaction	interaction	NN	NN	_	16	dobj	_	_
19	between	between	IN	IN	_	21	case	_	_
20	epithelial	epithelial	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	macrophages	macrophage	NNS	NNS	_	21	conj	_	_
24	regarding	regard	VBG	VBG	_	27	case	_	_
25	to	to	TO	TO	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	release	release	NN	NN	_	18	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	inflammatory	inflammatory	JJ	JJ	_	30	amod	_	_
30	mediators	mediator	NNS	NNS	_	27	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	For	for	IN	IN	_	2	mark	_	_
2	measuring	measure	VBG	VBG	_	19	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	contribution	contribution	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	macrophages	macrophage	NNS	NNS	_	4	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	release	release	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	inflammatory	inflammatory	JJ	JJ	_	12	amod	_	_
12	mediators	mediator	NNS	NNS	_	9	nmod	_	_
13	by	by	IN	IN	_	16	case	_	_
14	bronchial	bronchial	JJ	JJ	_	16	amod	_	_
15	epithelial	epithelial	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	,	,	,	,	_	19	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	established	establish	VBD	VBD	_	0	root	_	_
20	an	a	DT	DT	_	23	det	_	_
21	in	in	FW	FW	_	23	amod	_	_
22	vitro	vitro	FW	FW	_	21	dep	_	_
23	model	model	NN	NN	_	19	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	co-cultured	co-culture	VBN	VBN	_	27	amod	_	_
26	blood	blood	NN	NN	_	27	compound	_	_
27	monocytes	monocyte	NNS	NNS	_	23	nmod	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	BM	bm	NNS	NNS	_	27	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	and	and	CC	CC	_	27	cc	_	_
32	BEAS-2B	beas-2b	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	27	conj	_	_
34	in	in	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	transwell	transwell	NN	NN	_	37	compound	_	_
37	system	system	NN	NN	_	19	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	Costar	costar	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	19	punct	_	_

1	BM	bm	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	exposed	expose	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	6	case	_	_
5	Chrysotile	chrysotile	NN	NN	_	6	compound	_	_
6	B	b	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	soot	soot	NN	NN	_	10	compound	_	_
9	particle	particle	NN	NN	_	10	compound	_	_
10	FR	fr	NN	NN	_	6	conj	_	_
11	101	101	CD	CD	_	10	nummod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	concentration	concentration	NN	NN	_	3	nmod	_	_
15	of	of	IN	IN	_	20	case	_	_
16	100	100	CD	CD	_	20	nummod	_	_
17	microg	microg	NN	NN	_	20	compound	_	_
18	/	/	:	:	_	20	punct	_	_
19	10(6)	10(6)	CD	CD	_	20	nummod	_	_
20	cells	cell	NNS	NNS	_	14	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	After	after	IN	IN	_	8	case	_	_
2	up	up	RB	RB	_	4	advmod	_	_
3	to	to	TO	TO	_	4	dep	_	_
4	90	90	CD	CD	_	8	nummod	_	_
5	min	min	NN	NN	_	8	compound	_	_
6	exposure	exposure	NN	NN	_	8	compound	_	_
7	time	time	NN	NN	_	8	compound	_	_
8	ELISA	elisa	NN	NN	_	19	nmod	_	_
9	,	,	,	,	_	19	punct	_	_
10	EMSA	emsa	NN	NN	_	19	nsubjpass	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	electromobility	electromobility	NN	NN	_	14	compound	_	_
13	shift	shift	NN	NN	_	14	compound	_	_
14	assay	assay	NN	NN	_	10	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	RT-PCR	rt-pcr	NN	NN	_	10	conj	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	used	use	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	measure	measure	VB	VB	_	19	xcomp	_	_
22	protein	protein	NN	NN	_	25	compound	_	_
23	tyrosine	tyrosine	NN	NN	_	25	compound	_	_
24	kinase	kinase	NN	NN	_	25	compound	_	_
25	activity	activity	NN	NN	_	21	dobj	_	_
26	,	,	,	,	_	25	punct	_	_
27	protein	protein	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	25	appos	_	_
29	of	of	IN	IN	_	30	case	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	cytokine	cytokine	NN	NN	_	42	compound	_	_
33	(	(	-LRB-	-LRB-	_	34	punct	_	_
34	IL-1beta	il-1beta	NN	NN	_	32	dep	_	_
35	,	,	,	,	_	34	punct	_	_
36	IL-6	il-6	NN	NN	_	34	appos	_	_
37	,	,	,	,	_	34	punct	_	_
38	TNF-alpha	tnf-alpha	NN	NN	_	34	appos	_	_
39	)	)	-RRB-	-RRB-	_	34	punct	_	_
40	specific	specific	JJ	JJ	_	42	amod	_	_
41	mRNA	mrna	NN	NN	_	42	compound	_	_
42	levels	level	NNS	NNS	_	30	conj	_	_
43	in	in	IN	IN	_	45	case	_	_
44	BEAS-2B	beas-2b	NN	NN	_	45	compound	_	_
45	cells	cell	NNS	NNS	_	42	nmod	_	_
46	.	.	.	.	_	19	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	observed	observe	VBD	VBD	_	0	root	_	_
3	an	a	DT	DT	_	4	det	_	_
4	increase	increase	NN	NN	_	2	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	protein	protein	NN	NN	_	9	compound	_	_
7	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
8	kinase	kinase	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	nmod	_	_
10	(	(	-LRB-	-LRB-	_	13	punct	_	_
11	up	up	RB	RB	_	13	advmod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	1.8	1.8	CD	CD	_	9	nmod	_	_
14	+/-	+/-	CC	CC	_	13	cc	_	_
15	0.5-fold	0.5-fold	JJ	JJ	_	13	conj	_	_
16	)	)	-RRB-	-RRB-	_	13	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
19	protein	protein	NN	NN	_	20	compound	_	_
20	activity	activity	NN	NN	_	9	conj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	BEAS-2B	beas-2b	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	9	nmod	_	_
24	after	after	IN	IN	_	25	case	_	_
25	particle	particle	NN	NN	_	4	nmod	_	_
26	or	or	CC	CC	_	25	cc	_	_
27	fibre	fibre	JJ	JJ	_	25	conj	_	_
28	exposure	exposure	NN	NN	_	25	dep	_	_
29	of	of	IN	IN	_	31	case	_	_
30	co-cultured	co-culture	VBN	VBN	_	31	amod	_	_
31	BM	bm	NNS	NNS	_	25	nmod	_	_
32	.	.	.	.	_	2	punct	_	_

1	Consecutive	consecutive	JJ	JJ	_	2	amod	_	_
2	IL-1beta-	il-1beta-	NN	NN	_	8	nsubj	_	_
3	,	,	,	,	_	2	punct	_	_
4	IL-6-	il-6-	NN	NN	_	2	conj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	TNF-alpha-mRNA	tnf-alpha-mrna	NN	NN	_	2	conj	_	_
7	were	be	VBD	VBD	_	8	aux	_	_
8	elevated	elevated	JJ	JJ	_	0	root	_	_
9	(	(	-LRB-	-LRB-	_	12	punct	_	_
10	up	up	RB	RB	_	12	advmod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	1.9	1.9	CD	CD	_	8	dep	_	_
13	+/-	+/-	CC	CC	_	12	cc	_	_
14	0.58-fold	0.58-fold	JJ	JJ	_	12	conj	_	_
15	)	)	-RRB-	-RRB-	_	12	punct	_	_
16	.	.	.	.	_	8	punct	_	_

1	Protein	protein	NN	NN	_	4	compound	_	_
2	tyrosine	tyrosine	NN	NN	_	4	compound	_	_
3	kinase	kinase	NN	NN	_	4	compound	_	_
4	activity	activity	NN	NN	_	16	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	activity	activity	NN	NN	_	4	conj	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	synthesis	synthesis	NN	NN	_	4	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	cytokine-specific	cytokine-specific	JJ	JJ	_	14	amod	_	_
14	mRNA	mrna	NN	NN	_	11	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	inhibited	inhibit	VBN	VBN	_	0	root	_	_
17	by	by	IN	IN	_	18	case	_	_
18	antioxidants	antioxidant	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	8	det	_	_
5	ROI-dependent	roi-dependent	JJ	JJ	_	8	amod	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	8	compound	_	_
7	mediated	mediate	VBD	VBD	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	3	dobj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	cytokines	cytokine	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	bronchial	bronchial	JJ	JJ	_	15	amod	_	_
14	epithelial	epithelial	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	MHC-peptide	mhc-peptide	NN	NN	_	3	compound	_	_
2	ligand	ligand	NN	NN	_	3	compound	_	_
3	interactions	interaction	NNS	NNS	_	4	nsubj	_	_
4	establish	establish	VB	VB	_	0	root	_	_
5	a	a	DT	DT	_	7	det	_	_
6	functional	functional	JJ	JJ	_	7	amod	_	_
7	threshold	threshold	NN	NN	_	4	dobj	_	_
8	for	for	IN	IN	_	12	case	_	_
9	antigen-specific	antigen-specific	JJ	JJ	_	12	amod	_	_
10	T	t	NN	NN	_	12	compound	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	recognition	recognition	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Antigen-specific	antigen-specific	JJ	JJ	_	4	amod	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	recognition	recognition	NN	NN	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	dependent	dependent	JJ	JJ	_	0	root	_	_
7	on	on	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	density	density	NN	NN	_	6	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	TCR-ligand	tcr-ligand	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	consists	consist	VBZ	VBZ	_	13	acl:relcl	_	_
17	of	of	IN	IN	_	20	case	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	MHC	mhc	NN	NN	_	20	compound	_	_
20	molecules	molecule	NNS	NNS	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	a	a	DT	DT	_	25	det	_	_
23	specifically	specifically	RB	RB	_	25	advmod	_	_
24	bound	bind	VBN	VBN	_	25	amod	_	_
25	peptide	peptide	NN	NN	_	20	conj	_	_
26	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	influence	influence	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	affinity	affinity	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	concentration	concentration	NN	NN	_	8	conj	_	_
11	of	of	IN	IN	_	13	case	_	_
12	exogenous	exogenous	JJ	JJ	_	13	amod	_	_
13	peptide	peptide	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	the	the	DT	DT	_	16	det	_	_
16	density	density	NN	NN	_	5	conj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	specific	specific	JJ	JJ	_	20	amod	_	_
19	MHC	mhc	NN	NN	_	20	compound	_	_
20	molecules	molecule	NNS	NNS	_	16	nmod	_	_
21	on	on	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	proliferation	proliferation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	37	case	_	_
25	a	a	DT	DT	_	37	det	_	_
26	CD4+	cd4+	JJ	JJ	_	37	amod	_	_
27	,	,	,	,	_	37	punct	_	_
28	DQA1*0501/DQB1*0201	dqa1*0501/dqb1*0201	NN	NN	_	37	dep	_	_
29	(	(	-LRB-	-LRB-	_	37	punct	_	_
30	DQ2.1	dq2.1	NN	NN	_	37	compound	_	_
31	)	)	-RRB-	-RRB-	_	37	punct	_	_
32	-restricted	-restricted	JJ	JJ	_	37	amod	_	_
33	,	,	,	,	_	37	punct	_	_
34	HSV-2-specific	hsv-2-specific	JJ	JJ	_	37	amod	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	clone	clone	NN	NN	_	23	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	Using	use	VBG	VBG	_	17	advcl	_	_
2	antigen	antigen	JJ	JJ	_	4	amod	_	_
3	peptide	peptide	NN	NN	_	4	compound	_	_
4	analogs	analog	NNS	NNS	_	1	dobj	_	_
5	with	with	IN	IN	_	7	case	_	_
6	different	different	JJ	JJ	_	7	amod	_	_
7	mutations	mutation	NNS	NNS	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	known	known	JJ	JJ	_	11	amod	_	_
10	DQ2-anchor	dq2-anchor	NN	NN	_	11	compound	_	_
11	residues	residue	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	17	punct	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	response	response	NN	NN	_	17	nsubjpass	_	_
16	was	be	VBD	VBD	_	17	auxpass	_	_
17	reduced	reduce	VBN	VBN	_	0	root	_	_
18	in	in	IN	IN	_	20	case	_	_
19	an	a	DT	DT	_	20	det	_	_
20	peptide-affinity	peptide-affinity	NN	NN	_	17	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	-concentration	-concentration	NN	NN	_	24	compound	_	_
23	specific	specific	JJ	JJ	_	24	amod	_	_
24	manner	manner	NN	NN	_	20	conj	_	_
25	.	.	.	.	_	17	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	8	nsubj	_	_
3	using	use	VBG	VBG	_	2	acl	_	_
4	weaker	weaker	JJR	JJR	_	6	amod	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	peptides	peptide	NNS	NNS	_	3	dobj	_	_
7	was	be	VBD	VBD	_	8	cop	_	_
8	gradual	gradual	JJ	JJ	_	0	root	_	_
9	as	as	IN	IN	_	10	case	_	_
10	stimulation	stimulation	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	peptide	peptide	NN	NN	_	10	nmod	_	_
14	with	with	IN	IN	_	16	case	_	_
15	intermediate	intermediate	JJ	JJ	_	16	amod	_	_
16	affinity	affinity	NN	NN	_	13	nmod	_	_
17	yielded	yield	VBD	VBD	_	16	acl	_	_
18	intermediate	intermediate	JJ	JJ	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	proliferation	proliferation	NN	NN	_	17	dobj	_	_
22	and	and	CC	CC	_	8	cc	_	_
23	the	the	DT	DT	_	26	det	_	_
24	poorest	poorest	JJ	JJ	_	26	amod	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	peptide	peptide	NN	NN	_	27	nsubj	_	_
27	induced	induce	VBD	VBD	_	8	conj	_	_
28	an	a	DT	DT	_	33	det	_	_
29	even	even	RB	RB	_	30	advmod	_	_
30	weaker	weaker	JJR	JJR	_	33	amod	_	_
31	T	t	NN	NN	_	33	compound	_	_
32	cell	cell	NN	NN	_	33	compound	_	_
33	response	response	NN	NN	_	27	dobj	_	_
34	.	.	.	.	_	8	punct	_	_

1	MHC	mhc	NN	NN	_	4	compound	_	_
2	class	class	NN	NN	_	4	compound	_	_
3	II	ii	CD	CD	_	4	nummod	_	_
4	density	density	NN	NN	_	9	nsubjpass	_	_
5	on	on	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	APC	apc	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	modified	modify	VBN	VBN	_	0	root	_	_
10	using	use	VBG	VBG	_	9	xcomp	_	_
11	DQ2	dq2	NN	NN	_	10	dobj	_	_
12	homo-	homo-	JJ	JJ	_	11	amod	_	_
13	and	and	CC	CC	_	11	cc	_	_
14	heterozygous	heterozygous	JJ	JJ	_	15	amod	_	_
15	B-LCLs	b-lcl	NNS	NNS	_	11	conj	_	_
16	as	as	IN	IN	_	17	case	_	_
17	APCs	apc	NNS	NNS	_	10	nmod	_	_
18	,	,	,	,	_	9	punct	_	_
19	however	however	RB	RB	_	25	advmod	_	_
20	this	this	DT	DT	_	21	det	_	_
21	variation	variation	NN	NN	_	25	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	MHC	mhc	NN	NN	_	24	compound	_	_
24	concentration	concentration	NN	NN	_	21	nmod	_	_
25	had	have	VBD	VBD	_	9	parataxis	_	_
26	no	no	DT	DT	_	27	neg	_	_
27	effect	effect	NN	NN	_	25	dobj	_	_
28	on	on	IN	IN	_	31	case	_	_
29	T	t	NN	NN	_	31	compound	_	_
30	cell	cell	NN	NN	_	31	compound	_	_
31	proliferation	proliferation	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	interpret	interpret	VB	VB	_	0	root	_	_
3	this	this	DT	DT	_	2	dobj	_	_
4	as	as	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	reflection	reflection	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	10	case	_	_
8	a	a	DT	DT	_	10	det	_	_
9	low	low	JJ	JJ	_	10	amod	_	_
10	threshold	threshold	NN	NN	_	6	nmod	_	_
11	for	for	IN	IN	_	12	case	_	_
12	activation	activation	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	T	t	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	clone	clone	NN	NN	_	12	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	in	in	IN	IN	_	20	case	_	_
20	which	which	WDT	WDT	_	26	nmod	_	_
21	peptide-MHC	peptide-mhc	JJ	JJ	_	22	amod	_	_
22	avidity	avidity	NN	NN	_	26	nsubj	_	_
23	is	be	VBZ	VBZ	_	26	cop	_	_
24	the	the	DT	DT	_	26	det	_	_
25	over-riding	over-riding	JJ	JJ	_	26	amod	_	_
26	determinant	determinant	NN	NN	_	17	acl:relcl	_	_
27	of	of	IN	IN	_	29	case	_	_
28	the	the	DT	DT	_	29	det	_	_
29	strength	strength	NN	NN	_	26	nmod	_	_
30	of	of	IN	IN	_	32	case	_	_
31	ligand	ligand	NN	NN	_	32	compound	_	_
32	signal	signal	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	2	punct	_	_

1	Peptide	peptide	NN	NN	_	3	compound	_	_
2	binding	binding	NN	NN	_	3	compound	_	_
3	affinity	affinity	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	pH	ph	NN	NN	_	6	compound	_	_
6	variation	variation	NN	NN	_	3	conj	_	_
7	establish	establish	VBP	VBP	_	0	root	_	_
8	functional	functional	JJ	JJ	_	9	amod	_	_
9	thresholds	threshold	NNS	NNS	_	7	dobj	_	_
10	for	for	IN	IN	_	11	case	_	_
11	activation	activation	NN	NN	_	9	nmod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	HLA-DQ-restricted	hla-dq-restricted	JJ	JJ	_	16	amod	_	_
14	T	t	NN	NN	_	16	compound	_	_
15	cell	cell	NN	NN	_	16	compound	_	_
16	recognition	recognition	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Peptides	peptide	NNS	NNS	_	9	nsubjpass	_	_
2	derived	derive	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	HSV-2	hsv-2	NN	NN	_	7	compound	_	_
6	VP16	vp16	NN	NN	_	7	compound	_	_
7	protein	protein	NN	NN	_	2	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	utilized	utilize	VBN	VBN	_	0	root	_	_
10	for	for	IN	IN	_	11	case	_	_
11	studies	study	NNS	NNS	_	9	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	peptide	peptide	NN	NN	_	11	nmod	_	_
14	binding	bind	VBG	VBG	_	13	amod	_	_
15	to	to	TO	TO	_	17	case	_	_
16	DQ0302	dq0302	NN	NN	_	17	compound	_	_
17	molecules	molecule	NNS	NNS	_	13	nmod	_	_
18	and	and	CC	CC	_	13	cc	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	13	conj	_	_
22	at	at	IN	IN	_	24	case	_	_
23	both	both	CC	CC	_	24	cc:preconj	_	_
24	neutral	neutral	JJ	JJ	_	21	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	acidic	acidic	JJ	JJ	_	24	conj	_	_
27	pH	ph	NN	NN	_	24	dep	_	_
28	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	native	native	JJ	JJ	_	4	amod	_	_
3	peptide	peptide	NN	NN	_	4	compound	_	_
4	VP16	vp16	NN	NN	_	6	nsubj	_	_
5	430-444	430-444	CD	CD	_	4	nummod	_	_
6	contains	contain	VBZ	VBZ	_	0	root	_	_
7	an	a	DT	DT	_	8	det	_	_
8	Asp	asp	NN	NN	_	6	dobj	_	_
9	at	at	IN	IN	_	10	case	_	_
10	position	position	NN	NN	_	6	nmod	_	_
11	442	442	CD	CD	_	10	nummod	_	_
12	,	,	,	,	_	6	punct	_	_
13	binds	bind	VBZ	VBZ	_	6	dep	_	_
14	to	to	TO	TO	_	15	case	_	_
15	DQ0302	dq0302	NN	NN	_	13	nmod	_	_
16	strongly	strongly	RB	RB	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	with	with	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	Kd	kd	NN	NN	_	21	compound	_	_
21	value	value	NN	NN	_	16	conj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	50nM	50nm	NN	NN	_	21	nmod	_	_
24	at	at	IN	IN	_	26	case	_	_
25	acidic	acidic	JJ	JJ	_	26	amod	_	_
26	pH	ph	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	16	cc	_	_
28	very	very	RB	RB	_	29	advmod	_	_
29	weakly	weakly	RB	RB	_	16	conj	_	_
30	,	,	,	,	_	16	punct	_	_
31	with	with	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	Kd	kd	NN	NN	_	34	compound	_	_
34	value	value	NN	NN	_	16	conj	_	_
35	of	of	IN	IN	_	39	case	_	_
36	greater	greater	JJR	JJR	_	38	advmod	_	_
37	than	than	IN	IN	_	38	advmod	_	_
38	10	10	CD	CD	_	39	nummod	_	_
39	microM	microm	NN	NN	_	34	nmod	_	_
40	at	at	IN	IN	_	42	case	_	_
41	neutral	neutral	JJ	JJ	_	42	amod	_	_
42	pH	ph	NN	NN	_	34	nmod	_	_
43	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	truncated	truncate	VBN	VBN	_	3	amod	_	_
3	version	version	NN	NN	_	12	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	430-444	430-444	CD	CD	_	3	nmod	_	_
6	,	,	,	,	_	3	punct	_	_
7	i.e.	i.e.	FW	FW	_	9	dep	_	_
8	,	,	,	,	_	9	punct	_	_
9	VP16	vp16	NN	NN	_	3	nmod	_	_
10	433-442	433-442	CD	CD	_	9	nummod	_	_
11	,	,	,	,	_	12	punct	_	_
12	binds	bind	VBZ	VBZ	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	an	a	DT	DT	_	15	det	_	_
15	affinity	affinity	NN	NN	_	12	nmod	_	_
16	10-fold	10-fold	RB	RB	_	17	advmod	_	_
17	lower	lower	JJR	JJR	_	15	amod	_	_
18	compared	compare	VBN	VBN	_	20	case	_	_
19	to	to	TO	TO	_	20	case	_	_
20	430-444	430-444	CD	CD	_	17	advcl	_	_
21	at	at	IN	IN	_	23	case	_	_
22	acidic	acidic	JJ	JJ	_	23	amod	_	_
23	pH	ph	NN	NN	_	20	nmod	_	_
24	,	,	,	,	_	12	punct	_	_
25	and	and	CC	CC	_	12	cc	_	_
26	binding	binding	NN	NN	_	32	nsubj	_	_
27	at	at	IN	IN	_	29	case	_	_
28	neutral	neutral	JJ	JJ	_	29	amod	_	_
29	pH	ph	NN	NN	_	26	nmod	_	_
30	was	be	VBD	VBD	_	32	cop	_	_
31	barely	barely	RB	RB	_	32	advmod	_	_
32	detectable	detectable	JJ	JJ	_	12	conj	_	_
33	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	homologous	homologous	JJ	JJ	_	3	amod	_	_
3	peptide	peptide	NN	NN	_	5	nsubj	_	_
4	430-444,442A	430-444,442a	NN	NN	_	3	dep	_	_
5	has	have	VBZ	VBZ	_	0	root	_	_
6	an	a	DT	DT	_	7	det	_	_
7	Asp	asp	NN	NN	_	5	dobj	_	_
8	to	to	TO	TO	_	10	case	_	_
9	Ala	ala	NN	NN	_	10	compound	_	_
10	substitution	substitution	NN	NN	_	7	nmod	_	_
11	at	at	IN	IN	_	12	case	_	_
12	position	position	NN	NN	_	10	nmod	_	_
13	442	442	CD	CD	_	12	nummod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	binds	bind	VBZ	VBZ	_	5	conj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	DQ0302	dq0302	NN	NN	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	Kd	kd	NN	NN	_	17	nmod	_	_
21	similar	similar	JJ	JJ	_	20	amod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	433-442	433-442	CD	CD	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	short	short	JJ	JJ	_	4	amod	_	_
3	truncated	truncate	VBN	VBN	_	4	amod	_	_
4	analog	analog	NN	NN	_	6	nsubj	_	_
5	433-442A	433-442a	NN	NN	_	4	dep	_	_
6	binds	bind	VBZ	VBZ	_	0	root	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	poorly	poorly	RB	RB	_	6	advmod	_	_
9	at	at	IN	IN	_	11	case	_	_
10	both	both	CC	CC	_	11	cc:preconj	_	_
11	acidic	acidic	JJ	JJ	_	6	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	neutral	neutral	JJ	JJ	_	11	conj	_	_
14	pH	ph	NN	NN	_	11	dep	_	_
15	.	.	.	.	_	6	punct	_	_

1	Both	both	CC	CC	_	8	cc:preconj	_	_
2	the	the	DT	DT	_	8	det	_	_
3	wild	wild	JJ	JJ	_	8	amod	_	_
4	type	type	NN	NN	_	8	compound	_	_
5	430-444	430-444	CD	CD	_	8	compound	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	433-442	433-442	CD	CD	_	5	conj	_	_
8	peptides	peptide	NNS	NNS	_	9	nsubj	_	_
9	stimulated	stimulate	VBD	VBD	_	0	root	_	_
10	a	a	DT	DT	_	14	det	_	_
11	HSV-specific	hsv-specific	JJ	JJ	_	14	amod	_	_
12	T	t	NN	NN	_	14	compound	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	clone	clone	NN	NN	_	9	dobj	_	_
15	after	after	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	brief	brief	JJ	JJ	_	18	amod	_	_
18	incubation	incubation	NN	NN	_	9	nmod	_	_
19	with	with	IN	IN	_	22	case	_	_
20	antigen	antigen	NN	NN	_	22	compound	_	_
21	presenting	presenting	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	APC	apc	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	expressing	express	VBG	VBG	_	22	acl	_	_
27	DQ0302	dq0302	NN	NN	_	26	dobj	_	_
28	at	at	IN	IN	_	30	case	_	_
29	acidic	acidic	JJ	JJ	_	30	amod	_	_
30	pH	ph	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	9	punct	_	_

1	Much	much	RB	RB	_	2	advmod	_	_
2	higher	higher	JJR	JJR	_	3	amod	_	_
3	concentrations	concentration	NNS	NNS	_	9	nsubjpass	_	_
4	of	of	IN	IN	_	7	case	_	_
5	wild	wild	JJ	JJ	_	7	amod	_	_
6	type	type	NN	NN	_	7	compound	_	_
7	peptides	peptide	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	needed	need	VBN	VBN	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	activate	activate	VB	VB	_	9	xcomp	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	11	dobj	_	_
14	at	at	IN	IN	_	16	case	_	_
15	neutral	neutral	JJ	JJ	_	16	amod	_	_
16	pH	ph	NN	NN	_	11	nmod	_	_
17	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	APC	apc	NN	NN	_	15	nsubj	_	_
5	pulsed	pulsed	JJ	JJ	_	4	dep	_	_
6	with	with	IN	IN	_	8	case	_	_
7	Ala-substituted	ala-substituted	JJ	JJ	_	8	amod	_	_
8	peptides	peptide	NNS	NNS	_	5	nmod	_	_
9	430-444,442A	430-444,442a	NN	NN	_	8	dep	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	433-442A	433-442a	NN	NN	_	9	conj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	neutral	neutral	JJ	JJ	_	14	amod	_	_
14	pH	ph	NN	NN	_	5	nmod	_	_
15	failed	fail	VBD	VBD	_	0	root	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	stimulate	stimulate	VB	VB	_	15	xcomp	_	_
18	the	the	DT	DT	_	21	det	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	clone	clone	NN	NN	_	17	dobj	_	_
22	,	,	,	,	_	15	punct	_	_
23	while	while	IN	IN	_	15	dep	_	_
24	APC	apc	NN	NN	_	32	nsubj	_	_
25	pulsed	pulsed	JJ	JJ	_	24	dep	_	_
26	at	at	IN	IN	_	28	case	_	_
27	acidic	acidic	JJ	JJ	_	28	amod	_	_
28	pH	ph	NN	NN	_	25	nmod	_	_
29	and	and	CC	CC	_	25	cc	_	_
30	subsequently	subsequently	RB	RB	_	31	advmod	_	_
31	washed	wash	VBN	VBN	_	25	conj	_	_
32	led	lead	VBD	VBD	_	15	parataxis	_	_
33	to	to	TO	TO	_	37	case	_	_
34	successful	successful	JJ	JJ	_	37	amod	_	_
35	T	t	NN	NN	_	37	compound	_	_
36	cell	cell	NN	NN	_	37	compound	_	_
37	activation	activation	NN	NN	_	32	nmod	_	_
38	.	.	.	.	_	15	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Ala-substituted	ala-substituted	JJ	JJ	_	3	amod	_	_
3	peptide	peptide	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	recognized	recognize	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	10	case	_	_
7	the	the	DT	DT	_	10	det	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	clone	clone	NN	NN	_	5	nmod	_	_
11	at	at	IN	IN	_	13	case	_	_
12	neutral	neutral	JJ	JJ	_	13	amod	_	_
13	pH	ph	NN	NN	_	5	nmod	_	_
14	only	only	RB	RB	_	18	advmod	_	_
15	when	when	WRB	WRB	_	18	advmod	_	_
16	it	it	PRP	PRP	_	18	nsubj	_	_
17	was	be	VBD	VBD	_	18	cop	_	_
18	present	present	JJ	JJ	_	5	advcl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	APC	apc	NN	NN	_	22	compound	_	_
22	culture	culture	NN	NN	_	18	nmod	_	_
23	throughout	throughout	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	stimulation	stimulation	NN	NN	_	26	compound	_	_
26	process	process	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	5	punct	_	_

1	While	while	IN	IN	_	11	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	MHC-peptide	mhc-peptide	JJ	JJ	_	4	amod	_	_
4	complexes	complex	NNS	NNS	_	11	nsubj	_	_
5	formed	form	VBN	VBN	_	4	acl	_	_
6	with	with	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	native	native	JJ	JJ	_	9	amod	_	_
9	peptide	peptide	NN	NN	_	5	nmod	_	_
10	are	be	VBP	VBP	_	11	cop	_	_
11	stable	stable	JJ	JJ	_	19	advcl	_	_
12	,	,	,	,	_	19	punct	_	_
13	complexes	complex	NNS	NNS	_	19	nsubj	_	_
14	formed	form	VBN	VBN	_	13	acl	_	_
15	with	with	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	Ala-substituted	ala-substituted	JJ	JJ	_	18	amod	_	_
18	peptide	peptide	NN	NN	_	14	nmod	_	_
19	had	have	VBD	VBD	_	0	root	_	_
20	a	a	DT	DT	_	22	det	_	_
21	functional	functional	JJ	JJ	_	22	amod	_	_
22	t1/2	t1/2	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	less	less	JJR	JJR	_	26	advmod	_	_
25	than	than	IN	IN	_	24	mwe	_	_
26	4	4	CD	CD	_	27	nummod	_	_
27	hr	hr	NN	NN	_	22	nmod	_	_
28	at	at	IN	IN	_	30	case	_	_
29	neutral	neutral	JJ	JJ	_	30	amod	_	_
30	pH	ph	NN	NN	_	19	nmod	_	_
31	.	.	.	.	_	19	punct	_	_

1	Host	host	NN	NN	_	3	compound	_	_
2	defense	defense	NN	NN	_	3	compound	_	_
3	mechanisms	mechanism	NNS	NNS	_	0	root	_	_
4	triggered	trigger	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	microbial	microbial	JJ	JJ	_	7	amod	_	_
7	lipoproteins	lipoprotein	NNS	NNS	_	4	nmod	_	_
8	through	through	IN	IN	_	10	case	_	_
9	toll-like	toll-like	JJ	JJ	_	10	amod	_	_
10	receptors	receptor	NNS	NNS	_	4	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	generation	generation	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	cell-mediated	cell-mediated	JJ	JJ	_	5	amod	_	_
5	immunity	immunity	NN	NN	_	2	nmod	_	_
6	against	against	IN	IN	_	9	case	_	_
7	many	many	JJ	JJ	_	9	amod	_	_
8	infectious	infectious	JJ	JJ	_	9	amod	_	_
9	pathogens	pathogen	NNS	NNS	_	5	nmod	_	_
10	involves	involve	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	interleukin-12	interleukin-12	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	IL-12	il-12	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	14	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	key	key	JJ	JJ	_	21	amod	_	_
21	signal	signal	NN	NN	_	14	appos	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	innate	innate	JJ	JJ	_	26	amod	_	_
25	immune	immune	JJ	JJ	_	26	amod	_	_
26	system	system	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Yet	yet	RB	RB	_	23	advmod	_	_
2	,	,	,	,	_	23	punct	_	_
3	for	for	IN	IN	_	5	case	_	_
4	many	many	JJ	JJ	_	5	amod	_	_
5	pathogens	pathogen	NNS	NNS	_	23	nmod	_	_
6	,	,	,	,	_	23	punct	_	_
7	the	the	DT	DT	_	8	det	_	_
8	molecules	molecule	NNS	NNS	_	23	nsubj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	induce	induce	VBP	VBP	_	8	acl:relcl	_	_
11	IL-12	il-12	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	10	dobj	_	_
13	by	by	IN	IN	_	14	case	_	_
14	macrophages	macrophage	NNS	NNS	_	12	nmod	_	_
15	and	and	CC	CC	_	8	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mechanisms	mechanism	NNS	NNS	_	8	conj	_	_
18	by	by	IN	IN	_	19	case	_	_
19	which	which	WDT	WDT	_	21	nmod	_	_
20	they	they	PRP	PRP	_	21	nsubj	_	_
21	do	do	VBP	VBP	_	17	acl:relcl	_	_
22	so	so	RB	RB	_	21	advmod	_	_
23	remain	remain	VB	VB	_	0	root	_	_
24	undefined	undefined	JJ	JJ	_	23	xcomp	_	_
25	.	.	.	.	_	23	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	it	it	PRP	PRP	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	microbial	microbial	JJ	JJ	_	7	amod	_	_
7	lipoproteins	lipoprotein	NNS	NNS	_	10	nsubj	_	_
8	are	be	VBP	VBP	_	10	cop	_	_
9	potent	potent	JJ	JJ	_	10	amod	_	_
10	stimulators	stimulator	NNS	NNS	_	4	ccomp	_	_
11	of	of	IN	IN	_	13	case	_	_
12	IL-12	il-12	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	10	nmod	_	_
14	by	by	IN	IN	_	16	case	_	_
15	human	human	JJ	JJ	_	16	amod	_	_
16	macrophages	macrophage	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	10	punct	_	_
18	and	and	CC	CC	_	10	cc	_	_
19	that	that	IN	IN	_	22	mark	_	_
20	induction	induction	NN	NN	_	22	nsubjpass	_	_
21	is	be	VBZ	VBZ	_	22	auxpass	_	_
22	mediated	mediate	VBN	VBN	_	10	conj	_	_
23	by	by	IN	IN	_	25	case	_	_
24	Toll-like	toll-like	JJ	JJ	_	25	amod	_	_
25	receptors	receptor	NNS	NNS	_	22	nmod	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	TLRs	tlr	NNS	NNS	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	Several	several	JJ	JJ	_	2	amod	_	_
2	lipoproteins	lipoprotein	NNS	NNS	_	3	nsubj	_	_
3	stimulated	stimulate	VBD	VBD	_	0	root	_	_
4	TLR-dependent	tlr-dependent	JJ	JJ	_	5	amod	_	_
5	transcription	transcription	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	10	case	_	_
7	inducible	inducible	JJ	JJ	_	10	amod	_	_
8	nitric	nitric	JJ	JJ	_	10	amod	_	_
9	oxide	oxide	NN	NN	_	10	compound	_	_
10	synthase	synthase	NN	NN	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	the	the	DT	DT	_	13	det	_	_
13	production	production	NN	NN	_	5	conj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	nitric	nitric	JJ	JJ	_	16	amod	_	_
16	oxide	oxide	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	a	a	DT	DT	_	21	det	_	_
19	powerful	powerful	JJ	JJ	_	21	amod	_	_
20	microbicidal	microbicidal	NN	NN	_	21	compound	_	_
21	pathway	pathway	NN	NN	_	16	appos	_	_
22	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	TLRs	tlrs	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	6	case	_	_
5	microbial	microbial	JJ	JJ	_	6	amod	_	_
6	lipoproteins	lipoprotein	NNS	NNS	_	1	nmod	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	initiate	initiate	VB	VB	_	0	root	_	_
9	innate	innate	JJ	JJ	_	11	amod	_	_
10	defense	defense	NN	NN	_	11	compound	_	_
11	mechanisms	mechanism	NNS	NNS	_	8	dobj	_	_
12	against	against	IN	IN	_	14	case	_	_
13	infectious	infectious	JJ	JJ	_	14	amod	_	_
14	pathogens	pathogen	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	apoptosis	apoptosis	NN	NN	_	2	conj	_	_
5	by	by	IN	IN	_	7	case	_	_
6	bacterial	bacterial	JJ	JJ	_	7	amod	_	_
7	lipoproteins	lipoprotein	NNS	NNS	_	2	nmod	_	_
8	through	through	IN	IN	_	10	case	_	_
9	toll-like	toll-like	JJ	JJ	_	10	amod	_	_
10	receptor-2	receptor-2	NN	NN	_	2	nmod	_	_
11	.	.	.	.	_	2	punct	_	_

1	Apoptosis	apoptosis	NN	NN	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	implicated	implicate	VBN	VBN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	generation	generation	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	resolution	resolution	NN	NN	_	6	conj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	inflammation	inflammation	NN	NN	_	6	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	response	response	NN	NN	_	3	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	bacterial	bacterial	JJ	JJ	_	15	amod	_	_
15	pathogens	pathogen	NNS	NNS	_	12	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	All	all	DT	DT	_	3	det	_	_
2	bacterial	bacterial	JJ	JJ	_	3	amod	_	_
3	pathogens	pathogen	NNS	NNS	_	4	nsubj	_	_
4	produce	produce	VBP	VBP	_	0	root	_	_
5	lipoproteins	lipoprotein	NNS	NNS	_	4	dobj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	BLPs	blp	NNS	NNS	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	5	punct	_	_
10	which	which	WDT	WDT	_	11	nsubj	_	_
11	trigger	trigger	VBP	VBP	_	5	acl:relcl	_	_
12	the	the	DT	DT	_	15	det	_	_
13	innate	innate	JJ	JJ	_	15	amod	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	response	response	NN	NN	_	11	dobj	_	_
16	.	.	.	.	_	4	punct	_	_

1	BLPs	blp	NNS	NNS	_	3	nsubjpass	_	_
2	were	be	VBD	VBD	_	3	auxpass	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	induce	induce	VB	VB	_	3	xcomp	_	_
6	apoptosis	apoptosis	NN	NN	_	5	dobj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	THP-1	thp-1	NN	NN	_	10	compound	_	_
9	monocytic	monocytic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	6	nmod	_	_
11	through	through	IN	IN	_	14	case	_	_
12	human	human	JJ	JJ	_	14	amod	_	_
13	Toll-like	toll-like	JJ	JJ	_	14	amod	_	_
14	receptor-2	receptor-2	NN	NN	_	6	nmod	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	hTLR2	htlr2	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	.	.	.	.	_	3	punct	_	_

1	BLPs	blp	NNS	NNS	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	initiated	initiate	VBD	VBD	_	0	root	_	_
4	apoptosis	apoptosis	NN	NN	_	3	dobj	_	_
5	in	in	IN	IN	_	9	case	_	_
6	an	a	DT	DT	_	9	det	_	_
7	epithelial	epithelial	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	3	nmod	_	_
10	transfected	transfect	VBN	VBN	_	9	acl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	hTLR2	htlr2	NN	NN	_	10	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	BLPs	blp	NNS	NNS	_	5	nsubj	_	_
5	stimulated	stimulate	VBD	VBD	_	0	root	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor-kappaB	factor-kappab	NN	NN	_	5	dobj	_	_
8	,	,	,	,	_	7	punct	_	_
9	a	a	DT	DT	_	11	det	_	_
10	transcriptional	transcriptional	JJ	JJ	_	11	amod	_	_
11	activator	activator	NN	NN	_	7	appos	_	_
12	of	of	IN	IN	_	16	case	_	_
13	multiple	multiple	JJ	JJ	_	16	amod	_	_
14	host	host	NN	NN	_	16	compound	_	_
15	defense	defense	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	11	nmod	_	_
17	,	,	,	,	_	5	punct	_	_
18	and	and	CC	CC	_	5	cc	_	_
19	activated	activate	VBD	VBD	_	5	conj	_	_
20	the	the	DT	DT	_	22	det	_	_
21	respiratory	respiratory	JJ	JJ	_	22	amod	_	_
22	burst	burst	NN	NN	_	19	dobj	_	_
23	through	through	IN	IN	_	24	case	_	_
24	hTLR2	htlr2	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	hTLR2	htlr2	NN	NN	_	7	nsubj	_	_
4	is	be	VBZ	VBZ	_	7	cop	_	_
5	a	a	DT	DT	_	7	det	_	_
6	molecular	molecular	JJ	JJ	_	7	amod	_	_
7	link	link	NN	NN	_	0	root	_	_
8	between	between	IN	IN	_	10	case	_	_
9	microbial	microbial	JJ	JJ	_	10	amod	_	_
10	products	product	NNS	NNS	_	7	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	apoptosis	apoptosis	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	10	punct	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	host	host	NN	NN	_	17	compound	_	_
16	defense	defense	NN	NN	_	17	compound	_	_
17	mechanisms	mechanism	NNS	NNS	_	10	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	Diminished	diminish	VBN	VBN	_	2	amod	_	_
2	responses	response	NNS	NNS	_	8	nsubj	_	_
3	to	to	TO	TO	_	4	case	_	_
4	IL-13	il-13	NN	NN	_	2	nmod	_	_
5	by	by	IN	IN	_	7	case	_	_
6	human	human	JJ	JJ	_	7	amod	_	_
7	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
8	differentiated	differentiate	VBN	VBN	_	0	root	_	_
9	in	in	FW	FW	_	10	compound	_	_
10	vitro	vitro	FW	FW	_	8	advmod	_	_
11	:	:	:	:	_	8	punct	_	_
12	role	role	NN	NN	_	8	dep	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	dep	_	_
15	IL-13Ralpha1	il-13ralpha1	NN	NN	_	16	compound	_	_
16	chain	chain	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	STAT6	stat6	NN	NN	_	16	conj	_	_
19	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	primary	primary	JJ	JJ	_	5	amod	_	_
3	IL-13	il-13	NN	NN	_	5	compound	_	_
4	receptor	receptor	NN	NN	_	5	compound	_	_
5	complex	complex	NN	NN	_	10	nsubjpass	_	_
6	on	on	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	believed	believe	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	14	mark	_	_
12	be	be	VB	VB	_	14	cop	_	_
13	a	a	DT	DT	_	14	det	_	_
14	heterodimer	heterodimer	NN	NN	_	10	xcomp	_	_
15	comprised	comprise	VBN	VBN	_	14	acl	_	_
16	of	of	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	IL-4R	il-4r	NN	NN	_	20	compound	_	_
19	alpha	alpha	NN	NN	_	20	compound	_	_
20	chain	chain	NN	NN	_	15	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	the	the	DT	DT	_	30	det	_	_
23	IL-2R	il-2r	NN	NN	_	30	compound	_	_
24	gamma	gamma	NN	NN	_	30	compound	_	_
25	chain	chain	NN	NN	_	30	compound	_	_
26	(	(	-LRB-	-LRB-	_	30	punct	_	_
27	gamma(c)	gamma(c)	NN	NN	_	30	compound	_	_
28	)	)	-RRB-	-RRB-	_	30	punct	_	_
29	-like	-like	JJ	JJ	_	30	amod	_	_
30	molecule	molecule	NN	NN	_	20	conj	_	_
31	,	,	,	,	_	30	punct	_	_
32	IL-13R	il-13r	NN	NN	_	33	compound	_	_
33	alpha1	alpha1	NN	NN	_	30	appos	_	_
34	.	.	.	.	_	10	punct	_	_

1	mRNA	mrna	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	14	nsubjpass	_	_
3	for	for	IN	IN	_	5	case	_	_
4	IL-13R	il-13r	NN	NN	_	5	compound	_	_
5	alpha1	alpha1	NN	NN	_	2	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	5	cc	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	IL-4R	il-4r	NN	NN	_	10	compound	_	_
10	alpha	alpha	NN	NN	_	5	conj	_	_
11	,	,	,	,	_	14	punct	_	_
12	were	be	VBD	VBD	_	14	auxpass	_	_
13	markedly	markedly	RB	RB	_	14	advmod	_	_
14	decreased	decrease	VBN	VBN	_	0	root	_	_
15	in	in	IN	IN	_	19	case	_	_
16	in	in	FW	FW	_	19	compound	_	_
17	vitro	vitro	FW	FW	_	19	dep	_	_
18	monocyte-derived	monocyte-derived	JJ	JJ	_	19	amod	_	_
19	macrophages	macrophage	NNS	NNS	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MDMac	mdmac	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	14	punct	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	with	with	IN	IN	_	27	case	_	_
26	increasing	increase	VBG	VBG	_	27	amod	_	_
27	time	time	NN	NN	_	14	conj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	monocytes	monocyte	NNS	NNS	_	27	nmod	_	_
30	in	in	IN	IN	_	31	case	_	_
31	culture	culture	NN	NN	_	29	nmod	_	_
32	correlated	correlate	VBN	VBN	_	14	dep	_	_
33	with	with	IN	IN	_	35	case	_	_
34	the	the	DT	DT	_	35	det	_	_
35	loss	loss	NN	NN	_	32	nmod	_	_
36	of	of	IN	IN	_	38	case	_	_
37	IL-13	il-13	NN	NN	_	38	compound	_	_
38	regulation	regulation	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	lipopolysaccharide-induced	lipopolysaccharide-induced	JJ	JJ	_	42	amod	_	_
41	TNF-alpha	tnf-alpha	NN	NN	_	42	compound	_	_
42	production	production	NN	NN	_	38	nmod	_	_
43	.	.	.	.	_	14	punct	_	_

1	Analysis	analysis	NN	NN	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	1	nmod	_	_
5	Daudi	daudi	NN	NN	_	4	dep	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	THP-1	thp-1	NN	NN	_	5	conj	_	_
8	that	that	WDT	WDT	_	10	nsubj	_	_
9	differentially	differentially	RB	RB	_	10	advmod	_	_
10	express	express	VBP	VBP	_	4	acl:relcl	_	_
11	gamma(c)	gamma(c)	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-13R	il-13r	NN	NN	_	14	compound	_	_
14	alpha1	alpha1	NN	NN	_	11	conj	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	that	that	IN	IN	_	19	mark	_	_
17	IL-13	il-13	NN	NN	_	19	nsubj	_	_
18	can	can	MD	MD	_	19	aux	_	_
19	activate	activate	VB	VB	_	15	ccomp	_	_
20	STAT6	stat6	NN	NN	_	19	dobj	_	_
21	in	in	IN	IN	_	25	case	_	_
22	IL-13R	il-13r	NN	NN	_	25	compound	_	_
23	alpha1-positive	alpha1-positive	JJ	JJ	_	25	amod	_	_
24	THP-1	thp-1	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	20	nmod	_	_
26	but	but	CC	CC	_	25	cc	_	_
27	not	not	RB	RB	_	34	neg	_	_
28	in	in	IN	IN	_	34	case	_	_
29	gamma(c)-positive	gamma(c)-positive	JJ	JJ	_	34	amod	_	_
30	,	,	,	,	_	34	punct	_	_
31	IL-13R	il-13r	NN	NN	_	34	compound	_	_
32	alpha1-negative	alpha1-negative	JJ	JJ	_	34	amod	_	_
33	Daudi	daudi	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	25	conj	_	_
35	.	.	.	.	_	15	punct	_	_

1	IL-13	il-13	NN	NN	_	2	compound	_	_
2	activation	activation	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	STAT6	stat6	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	reduced	reduce	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	8	case	_	_
8	MDMac	mdmac	NN	NN	_	6	nmod	_	_
9	which	which	WDT	WDT	_	11	nsubjpass	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	associated	associate	VBN	VBN	_	8	acl:relcl	_	_
12	with	with	IN	IN	_	15	case	_	_
13	diminished	diminish	VBN	VBN	_	15	amod	_	_
14	IL-13-induced	il-13-induced	JJ	JJ	_	15	amod	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	CD23	cd23	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	MHC	mhc	NN	NN	_	20	compound	_	_
20	class	class	NN	NN	_	17	conj	_	_
21	II	ii	CD	CD	_	20	nummod	_	_
22	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	with	with	IN	IN	_	7	case	_	_
4	reduced	reduce	VBN	VBN	_	7	amod	_	_
5	IL-13R	il-13r	NN	NN	_	7	compound	_	_
6	alpha1	alpha1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	18	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	low	low	JJ	JJ	_	12	amod	_	_
10	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
11	STAT6	stat6	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	7	conj	_	_
13	,	,	,	,	_	18	punct	_	_
14	some	some	DT	DT	_	16	det	_	_
15	IL-13-induced	il-13-induced	JJ	JJ	_	16	amod	_	_
16	responses	response	NNS	NNS	_	18	nsubj	_	_
17	were	be	VBD	VBD	_	18	aux	_	_
18	unaltered	unaltered	JJ	JJ	_	0	root	_	_
19	in	in	IN	IN	_	20	case	_	_
20	magnitude	magnitude	NN	NN	_	18	nmod	_	_
21	in	in	IN	IN	_	22	case	_	_
22	MDMac	mdmac	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	18	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	absence	absence	NN	NN	_	13	nmod	_	_
4	of	of	IN	IN	_	7	case	_	_
5	functional	functional	JJ	JJ	_	7	amod	_	_
6	IL-13R	il-13r	NN	NN	_	7	compound	_	_
7	alpha1	alpha1	NN	NN	_	3	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	gamma(c)	gamma(c)	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	13	punct	_	_
11	IL-13	il-13	NN	NN	_	13	nsubj	_	_
12	must	must	MD	MD	_	13	aux	_	_
13	signal	signal	VB	VB	_	0	root	_	_
14	through	through	IN	IN	_	18	case	_	_
15	an	a	DT	DT	_	18	det	_	_
16	alternative	alternative	JJ	JJ	_	18	amod	_	_
17	receptor	receptor	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	13	nmod	_	_
19	on	on	IN	IN	_	20	case	_	_
20	MDMac	mdmac	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Experiments	experiment	NNS	NNS	_	9	nsubj	_	_
2	with	with	IN	IN	_	5	case	_	_
3	a	a	DT	DT	_	5	det	_	_
4	blocking	block	VBG	VBG	_	5	amod	_	_
5	antibody	antibody	NN	NN	_	1	nmod	_	_
6	to	to	TO	TO	_	8	case	_	_
7	IL-4R	il-4r	NN	NN	_	8	compound	_	_
8	alpha	alpha	NN	NN	_	5	nmod	_	_
9	showed	show	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	13	mark	_	_
11	this	this	DT	DT	_	12	det	_	_
12	chain	chain	NN	NN	_	13	nsubj	_	_
13	remains	remain	VBZ	VBZ	_	9	ccomp	_	_
14	an	a	DT	DT	_	16	det	_	_
15	essential	essential	JJ	JJ	_	16	amod	_	_
16	component	component	NN	NN	_	13	xcomp	_	_
17	of	of	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	IL-13	il-13	NN	NN	_	21	compound	_	_
20	receptor	receptor	NN	NN	_	21	compound	_	_
21	complex	complex	NN	NN	_	16	nmod	_	_
22	on	on	IN	IN	_	23	case	_	_
23	MDMac	mdmac	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	9	punct	_	_

1	Tissue-specific	tissue-specific	JJ	JJ	_	2	amod	_	_
2	regulation	regulation	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	ecto-5'-nucleotidase	ecto-5'-nucleotidase	JJ	JJ	_	6	amod	_	_
6	promoter	promoter	NN	NN	_	2	nmod	_	_
7	.	.	.	.	_	2	punct	_	_

1	Role	role	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	camp	camp	NN	NN	_	7	compound	_	_
5	response	response	NN	NN	_	7	compound	_	_
6	element	element	NN	NN	_	7	compound	_	_
7	site	site	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	9	mark	_	_
9	mediating	mediate	VBG	VBG	_	1	acl	_	_
10	repression	repression	NN	NN	_	9	dobj	_	_
11	by	by	IN	IN	_	15	case	_	_
12	the	the	DT	DT	_	15	det	_	_
13	upstream	upstream	JJ	JJ	_	15	amod	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	region	region	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	isolated	isolate	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	5'	5'	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	18	case	_	_
8	the	the	DT	DT	_	18	det	_	_
9	ecto-5'-nucleotidase	ecto-5'-nucleotidase	JJ	JJ	_	18	amod	_	_
10	(	(	-LRB-	-LRB-	_	18	punct	_	_
11	low	low	JJ	JJ	_	18	amod	_	_
12	K	k	NN	NN	_	18	compound	_	_
13	(	(	-LRB-	-LRB-	_	18	punct	_	_
14	m	m	NN	NN	_	18	compound	_	_
15	)	)	-RRB-	-RRB-	_	18	punct	_	_
16	5'-NT	5'-nt	JJ	JJ	_	18	amod	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	gene	gene	NN	NN	_	6	nmod	_	_
19	and	and	CC	CC	_	3	cc	_	_
20	established	establish	VBD	VBD	_	3	conj	_	_
21	that	that	IN	IN	_	30	mark	_	_
22	a	a	DT	DT	_	29	det	_	_
23	969-	969-	NN	NN	_	29	compound	_	_
24	base	base	JJ	JJ	_	25	amod	_	_
25	pair	pair	NN	NN	_	29	compound	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	bp	bp	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	fragment	fragment	NN	NN	_	30	nsubj	_	_
30	confers	confer	VBZ	VBZ	_	20	ccomp	_	_
31	cell-specific	cell-specific	JJ	JJ	_	32	amod	_	_
32	expression	expression	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	a	a	DT	DT	_	37	det	_	_
35	CAT	cat	NN	NN	_	37	compound	_	_
36	reporter	reporter	NN	NN	_	37	compound	_	_
37	gene	gene	NN	NN	_	32	nmod	_	_
38	that	that	WDT	WDT	_	39	nsubj	_	_
39	correlates	correlate	VBZ	VBZ	_	37	acl:relcl	_	_
40	with	with	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	expression	expression	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	46	case	_	_
44	endogenous	endogenous	JJ	JJ	_	46	amod	_	_
45	ecto-5'-NT	ecto-5'-nt	JJ	JJ	_	46	amod	_	_
46	mRNA	mrna	NN	NN	_	42	nmod	_	_
47	and	and	CC	CC	_	42	cc	_	_
48	enzymatic	enzymatic	JJ	JJ	_	49	amod	_	_
49	activity	activity	NN	NN	_	42	conj	_	_
50	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	6	det	_	_
2	768-bp	768-bp	JJ	JJ	_	6	amod	_	_
3	upstream	upstream	JJ	JJ	_	6	amod	_	_
4	negative	negative	JJ	JJ	_	6	amod	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	region	region	NN	NN	_	9	nsubjpass	_	_
7	has	have	VBZ	VBZ	_	9	aux	_	_
8	been	be	VBN	VBN	_	9	auxpass	_	_
9	identified	identify	VBN	VBN	_	0	root	_	_
10	that	that	WDT	WDT	_	11	dep	_	_
11	conferred	confer	VBD	VBD	_	9	ccomp	_	_
12	lymphocyte-specific	lymphocyte-specific	JJ	JJ	_	14	amod	_	_
13	negative	negative	JJ	JJ	_	14	amod	_	_
14	regulation	regulation	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	heterologous	heterologous	JJ	JJ	_	18	amod	_	_
18	system	system	NN	NN	_	14	nmod	_	_
19	with	with	IN	IN	_	25	case	_	_
20	a	a	DT	DT	_	25	det	_	_
21	244-bp	244-bp	JJ	JJ	_	25	amod	_	_
22	deoxycytidine	deoxycytidine	NN	NN	_	25	compound	_	_
23	kinase	kinase	NN	NN	_	25	compound	_	_
24	core	core	NN	NN	_	25	compound	_	_
25	promoter	promoter	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	DNase	dnase	NN	NN	_	3	compound	_	_
2	I	i	CD	CD	_	3	nummod	_	_
3	footprinting	footprinting	NN	NN	_	4	nsubj	_	_
4	identified	identify	VBD	VBD	_	0	root	_	_
5	several	several	JJ	JJ	_	7	amod	_	_
6	protected	protected	JJ	JJ	_	7	amod	_	_
7	areas	area	NNS	NNS	_	4	dobj	_	_
8	including	include	VBG	VBG	_	9	case	_	_
9	Sp1	sp1	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	Sp1/AP-2	sp1/ap-2	NN	NN	_	9	conj	_	_
12	,	,	,	,	_	9	punct	_	_
13	and	and	CC	CC	_	9	cc	_	_
14	cAMP	camp	NN	NN	_	16	compound	_	_
15	response	response	NN	NN	_	16	compound	_	_
16	element	element	NN	NN	_	9	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	CRE	cre	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	binding	binding	NN	NN	_	21	compound	_	_
21	sites	site	NNS	NNS	_	9	dep	_	_
22	within	within	IN	IN	_	27	case	_	_
23	the	the	DT	DT	_	27	det	_	_
24	201-bp	201-bp	JJ	JJ	_	27	amod	_	_
25	core	core	NN	NN	_	27	compound	_	_
26	promoter	promoter	NN	NN	_	27	compound	_	_
27	region	region	NN	NN	_	9	nmod	_	_
28	and	and	CC	CC	_	9	cc	_	_
29	Sp1	sp1	NN	NN	_	9	conj	_	_
30	,	,	,	,	_	29	punct	_	_
31	NRE-2a	nre-2a	NN	NN	_	29	conj	_	_
32	,	,	,	,	_	29	punct	_	_
33	TCF-1/LEF-1	tcf-1/lef-1	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	Sp1/NF-AT	sp1/nf-at	NN	NN	_	29	conj	_	_
37	binding	binding	NN	NN	_	38	compound	_	_
38	sites	site	NNS	NNS	_	29	dep	_	_
39	in	in	IN	IN	_	43	case	_	_
40	the	the	DT	DT	_	43	det	_	_
41	upstream	upstream	JJ	JJ	_	43	amod	_	_
42	regulatory	regulatory	JJ	JJ	_	43	amod	_	_
43	region	region	NN	NN	_	29	nmod	_	_
44	.	.	.	.	_	4	punct	_	_

1	Whereas	whereas	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	CRE	cre	NN	NN	_	4	compound	_	_
4	site	site	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	essential	essential	JJ	JJ	_	30	advcl	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	mediating	mediate	VBG	VBG	_	6	advcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	negative	negative	JJ	JJ	_	11	amod	_	_
11	activity	activity	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	upstream	upstream	JJ	JJ	_	16	amod	_	_
15	regulatory	regulatory	JJ	JJ	_	16	amod	_	_
16	region	region	NN	NN	_	11	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	Jurkat	jurkat	NN	NN	_	16	nmod	_	_
19	but	but	CC	CC	_	18	cc	_	_
20	not	not	RB	RB	_	23	neg	_	_
21	in	in	IN	IN	_	23	case	_	_
22	HeLa	hela	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	18	conj	_	_
24	,	,	,	,	_	30	punct	_	_
25	mutation	mutation	NN	NN	_	30	nsubj	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	Sp1/AP-2	sp1/ap-2	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	25	nmod	_	_
30	decreased	decrease	VBD	VBD	_	0	root	_	_
31	promoter	promoter	NN	NN	_	32	compound	_	_
32	activity	activity	NN	NN	_	30	dobj	_	_
33	in	in	IN	IN	_	36	case	_	_
34	both	both	DT	DT	_	36	det	_	_
35	cell	cell	NN	NN	_	36	compound	_	_
36	lines	line	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	30	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
2	mobility	mobility	NN	NN	_	5	compound	_	_
3	shift	shift	NN	NN	_	5	compound	_	_
4	assay	assay	NN	NN	_	5	compound	_	_
5	analysis	analysis	NN	NN	_	13	nsubj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	proteins	protein	NNS	NNS	_	5	nmod	_	_
8	binding	bind	VBG	VBG	_	7	acl	_	_
9	to	to	TO	TO	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	CRE	cre	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	8	nmod	_	_
13	identified	identify	VBD	VBD	_	0	root	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	ATF-1	atf-1	NN	NN	_	13	dobj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	ATF-2	atf-2	NN	NN	_	15	conj	_	_
18	in	in	IN	IN	_	20	case	_	_
19	Jurkat	jurkat	NN	NN	_	20	compound	_	_
20	cells	cell	NNS	NNS	_	15	nmod	_	_
21	.	.	.	.	_	13	punct	_	_

1	Finally	finally	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	phorbol	phorbol	NN	NN	_	5	compound	_	_
4	12-myristate	12-myristate	NN	NN	_	5	compound	_	_
5	13-acetate	13-acetate	NN	NN	_	6	nsubj	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	both	both	CC	CC	_	12	cc:preconj	_	_
11	the	the	DT	DT	_	12	det	_	_
12	core	core	NN	NN	_	8	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	the	the	DT	DT	_	17	det	_	_
15	969-bp	969-bp	JJ	JJ	_	17	amod	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	fragments	fragment	NNS	NNS	_	12	conj	_	_
18	,	,	,	,	_	6	punct	_	_
19	and	and	CC	CC	_	6	cc	_	_
20	this	this	DT	DT	_	21	det	_	_
21	increase	increase	NN	NN	_	23	nsubjpass	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	abrogated	abrogate	VBN	VBN	_	6	conj	_	_
24	by	by	IN	IN	_	25	case	_	_
25	mutations	mutation	NNS	NNS	_	23	nmod	_	_
26	at	at	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	CRE	cre	NN	NN	_	29	compound	_	_
29	site	site	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	we	we	PRP	PRP	_	6	nsubj	_	_
5	have	have	VBP	VBP	_	6	aux	_	_
6	identified	identify	VBN	VBN	_	0	root	_	_
7	a	a	DT	DT	_	10	det	_	_
8	tissue-specific	tissue-specific	JJ	JJ	_	10	amod	_	_
9	regulatory	regulatory	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	6	dobj	_	_
11	5'	5'	JJ	JJ	_	10	amod	_	_
12	of	of	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	ecto-5'-NT	ecto-5'-nt	JJ	JJ	_	16	amod	_	_
15	core	core	NN	NN	_	16	compound	_	_
16	promoter	promoter	NN	NN	_	10	nmod	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	requires	require	VBZ	VBZ	_	16	acl:relcl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	presence	presence	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	25	case	_	_
22	a	a	DT	DT	_	25	det	_	_
23	functional	functional	JJ	JJ	_	25	amod	_	_
24	CRE	cre	NN	NN	_	25	compound	_	_
25	site	site	NN	NN	_	20	nmod	_	_
26	within	within	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	basal	basal	JJ	JJ	_	29	amod	_	_
29	promoter	promoter	NN	NN	_	25	nmod	_	_
30	for	for	IN	IN	_	33	case	_	_
31	its	its	PRP$	PRP$	_	33	nmod:poss	_	_
32	suppressive	suppressive	JJ	JJ	_	33	amod	_	_
33	activity	activity	NN	NN	_	29	nmod	_	_
34	.	.	.	.	_	6	punct	_	_

1	Monoallelic	monoallelic	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Pax5	pax5	NN	NN	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	a	a	DT	DT	_	7	det	_	_
7	paradigm	paradigm	NN	NN	_	2	dep	_	_
8	for	for	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	haploinsufficiency	haploinsufficiency	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	mammalian	mammalian	JJ	JJ	_	14	amod	_	_
13	Pax	pax	NN	NN	_	14	compound	_	_
14	genes	gene	NNS	NNS	_	10	nmod	_	_
15	?	?	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	generally	generally	RB	RB	_	4	advmod	_	_
4	assumed	assume	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	most	most	JJS	JJS	_	8	amod	_	_
7	mammalian	mammalian	JJ	JJ	_	8	amod	_	_
8	genes	gene	NNS	NNS	_	10	nsubjpass	_	_
9	are	be	VBP	VBP	_	10	auxpass	_	_
10	transcribed	transcribe	VBN	VBN	_	4	ccomp	_	_
11	from	from	IN	IN	_	13	case	_	_
12	both	both	DT	DT	_	13	det	_	_
13	alleles	allele	NNS	NNS	_	10	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Hence	hence	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	diploid	diploid	JJ	JJ	_	5	amod	_	_
5	state	state	NN	NN	_	9	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	genome	genome	NN	NN	_	5	nmod	_	_
9	offers	offer	VBZ	VBZ	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	advantage	advantage	NN	NN	_	9	dobj	_	_
12	that	that	IN	IN	_	21	mark	_	_
13	a	a	DT	DT	_	15	det	_	_
14	loss-of-function	loss-of-function	JJ	JJ	_	15	amod	_	_
15	mutation	mutation	NN	NN	_	21	nsubjpass	_	_
16	in	in	IN	IN	_	18	case	_	_
17	one	one	CD	CD	_	18	nummod	_	_
18	allele	allele	NN	NN	_	15	nmod	_	_
19	can	can	MD	MD	_	21	aux	_	_
20	be	be	VB	VB	_	21	auxpass	_	_
21	compensated	compensate	VBN	VBN	_	11	dep	_	_
22	for	for	IN	IN	_	21	compound:prt	_	_
23	by	by	IN	IN	_	27	case	_	_
24	the	the	DT	DT	_	27	det	_	_
25	remaining	remain	VBG	VBG	_	27	amod	_	_
26	wild-type	wild-type	JJ	JJ	_	27	amod	_	_
27	allele	allele	NN	NN	_	21	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	same	same	JJ	JJ	_	31	amod	_	_
31	gene	gene	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	9	punct	_	_

1	Indeed	indeed	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	vast	vast	JJ	JJ	_	5	amod	_	_
5	majority	majority	NN	NN	_	18	nsubj	_	_
6	of	of	IN	IN	_	9	case	_	_
7	human	human	JJ	JJ	_	9	amod	_	_
8	disease	disease	NN	NN	_	9	compound	_	_
9	syndromes	syndrome	NNS	NNS	_	5	nmod	_	_
10	and	and	CC	CC	_	5	cc	_	_
11	engineered	engineer	VBN	VBN	_	12	amod	_	_
12	mutations	mutation	NNS	NNS	_	5	conj	_	_
13	in	in	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	mouse	mouse	NN	NN	_	16	compound	_	_
16	genome	genome	NN	NN	_	12	nmod	_	_
17	are	be	VBP	VBP	_	18	cop	_	_
18	recessive	recessive	JJ	JJ	_	0	root	_	_
19	,	,	,	,	_	18	punct	_	_
20	indicating	indicate	VBG	VBG	_	18	dep	_	_
21	that	that	IN	IN	_	28	mark	_	_
22	recessiveness	recessiveness	NN	NN	_	28	nsubj	_	_
23	is	be	VBZ	VBZ	_	28	cop	_	_
24	the	the	DT	DT	_	28	det	_	_
25	'	'	``	``	_	28	punct	_	_
26	default	default	NN	NN	_	28	compound	_	_
27	'	'	''	''	_	28	punct	_	_
28	state	state	NN	NN	_	20	ccomp	_	_
29	.	.	.	.	_	18	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	4	det	_	_
4	minority	minority	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	genes	gene	NNS	NNS	_	4	nmod	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	semi-dominant	semi-dominant	JJ	JJ	_	0	root	_	_
9	,	,	,	,	_	8	punct	_	_
10	as	as	IN	IN	_	17	mark	_	_
11	heterozygous	heterozygous	JJ	JJ	_	13	amod	_	_
12	loss-of-function	loss-of-function	JJ	JJ	_	13	amod	_	_
13	mutation	mutation	NN	NN	_	17	nsubj	_	_
14	in	in	IN	IN	_	16	case	_	_
15	these	these	DT	DT	_	16	det	_	_
16	genes	gene	NNS	NNS	_	13	nmod	_	_
17	leads	lead	VBZ	VBZ	_	8	advcl	_	_
18	to	to	TO	TO	_	20	case	_	_
19	phenotypic	phenotypic	JJ	JJ	_	20	amod	_	_
20	abnormalities	abnormality	NNS	NNS	_	17	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	condition	condition	NN	NN	_	10	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	known	know	VBN	VBN	_	2	acl	_	_
5	as	as	IN	IN	_	6	case	_	_
6	haploinsufficiency	haploinsufficiency	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	10	punct	_	_
8	has	have	VBZ	VBZ	_	10	aux	_	_
9	been	be	VBN	VBN	_	10	auxpass	_	_
10	described	describe	VBN	VBN	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	five	five	CD	CD	_	10	nmod	_	_
13	of	of	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	nine	nine	CD	CD	_	18	nummod	_	_
16	mammalian	mammalian	JJ	JJ	_	18	amod	_	_
17	Pax	pax	NN	NN	_	18	compound	_	_
18	genes	gene	NNS	NNS	_	12	nmod	_	_
19	,	,	,	,	_	18	punct	_	_
20	which	which	WDT	WDT	_	22	nsubjpass	_	_
21	are	be	VBP	VBP	_	22	auxpass	_	_
22	associated	associate	VBN	VBN	_	18	acl:relcl	_	_
23	with	with	IN	IN	_	26	case	_	_
24	mouse	mouse	NN	NN	_	26	compound	_	_
25	developmental	developmental	JJ	JJ	_	26	amod	_	_
26	mutants	mutant	NNS	NNS	_	22	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	human	human	JJ	JJ	_	30	amod	_	_
29	disease	disease	NN	NN	_	30	compound	_	_
30	syndromes	syndrome	NNS	NNS	_	26	conj	_	_
31	.	.	.	.	_	10	punct	_	_

1	Recently	recently	RB	RB	_	4	advmod	_	_
2	we	we	PRP	PRP	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	8	det	_	_
7	Pax5	pax5	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	10	nsubj	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	subject	subject	JJ	JJ	_	4	ccomp	_	_
11	to	to	TO	TO	_	13	case	_	_
12	allele-specific	allele-specific	JJ	JJ	_	13	amod	_	_
13	regulation	regulation	NN	NN	_	10	nmod	_	_
14	during	during	IN	IN	_	17	case	_	_
15	B	b	NN	NN	_	17	compound	_	_
16	cell	cell	NN	NN	_	17	compound	_	_
17	development	development	NN	NN	_	10	nmod	_	_
18	.	.	.	.	_	4	punct	_	_

1	Pax5	pax5	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	predominantly	predominantly	RB	RB	_	4	advmod	_	_
4	transcribed	transcribe	VBN	VBN	_	0	root	_	_
5	from	from	IN	IN	_	7	case	_	_
6	only	only	RB	RB	_	7	advmod	_	_
7	one	one	CD	CD	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	its	its	PRP$	PRP$	_	11	nmod:poss	_	_
10	two	two	CD	CD	_	11	nummod	_	_
11	alleles	allele	NNS	NNS	_	7	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	early	early	JJ	JJ	_	15	amod	_	_
14	B-lymphoid	b-lymphoid	JJ	JJ	_	15	amod	_	_
15	progenitors	progenitor	NNS	NNS	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	mature	mature	JJ	JJ	_	19	amod	_	_
18	B	b	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	conj	_	_
20	,	,	,	,	_	4	punct	_	_
21	while	while	IN	IN	_	4	dep	_	_
22	it	it	PRP	PRP	_	24	nsubj	_	_
23	transiently	transiently	RB	RB	_	24	advmod	_	_
24	switches	switch	VBZ	VBZ	_	4	parataxis	_	_
25	to	to	TO	TO	_	28	case	_	_
26	a	a	DT	DT	_	28	det	_	_
27	biallelic	biallelic	JJ	JJ	_	28	amod	_	_
28	mode	mode	NN	NN	_	24	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	transcription	transcription	NN	NN	_	28	nmod	_	_
31	in	in	IN	IN	_	32	case	_	_
32	pre-B	pre-b	NN	NN	_	24	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	immature	immature	JJ	JJ	_	35	amod	_	_
35	B	b	NN	NN	_	32	conj	_	_
36	cells	cell	NNS	NNS	_	32	dep	_	_
37	.	.	.	.	_	4	punct	_	_

1	As	as	IN	IN	_	3	case	_	_
2	a	a	DT	DT	_	3	det	_	_
3	consequence	consequence	NN	NN	_	8	nmod	_	_
4	,	,	,	,	_	8	punct	_	_
5	B-lymphoid	b-lymphoid	JJ	JJ	_	6	amod	_	_
6	tissues	tissue	NNS	NNS	_	8	nsubj	_	_
7	are	be	VBP	VBP	_	8	cop	_	_
8	mosaic	mosaic	JJ	JJ	_	0	root	_	_
9	with	with	IN	IN	_	10	case	_	_
10	regard	regard	NN	NN	_	8	nmod	_	_
11	to	to	TO	TO	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	transcribed	transcribe	VBN	VBN	_	14	amod	_	_
14	allele	allele	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	8	punct	_	_
16	and	and	CC	CC	_	8	cc	_	_
17	heterozygous	heterozygous	JJ	JJ	_	18	amod	_	_
18	mutation	mutation	NN	NN	_	22	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Pax5	pax5	NN	NN	_	18	nmod	_	_
21	therefore	therefore	RB	RB	_	22	advmod	_	_
22	results	result	VBZ	VBZ	_	8	conj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	deletion	deletion	NN	NN	_	22	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
28	expressing	express	VBG	VBG	_	27	acl	_	_
29	only	only	RB	RB	_	28	advmod	_	_
30	the	the	DT	DT	_	32	det	_	_
31	mutant	mutant	JJ	JJ	_	32	amod	_	_
32	allele	allele	NN	NN	_	28	dobj	_	_
33	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	allele-specific	allele-specific	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	6	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	Pax5	pax5	NN	NN	_	3	nmod	_	_
6	raises	raise	VBZ	VBZ	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	intriguing	intriguing	JJ	JJ	_	9	amod	_	_
9	possibility	possibility	NN	NN	_	6	dobj	_	_
10	that	that	IN	IN	_	17	mark	_	_
11	monoallelic	monoallelic	JJ	JJ	_	12	amod	_	_
12	expression	expression	NN	NN	_	17	nsubj	_	_
13	may	may	MD	MD	_	17	aux	_	_
14	also	also	RB	RB	_	17	advmod	_	_
15	be	be	VB	VB	_	17	cop	_	_
16	the	the	DT	DT	_	17	det	_	_
17	mechanism	mechanism	NN	NN	_	9	dep	_	_
18	causing	cause	VBG	VBG	_	17	acl	_	_
19	the	the	DT	DT	_	20	det	_	_
20	haploinsufficiency	haploinsufficiency	NN	NN	_	18	dobj	_	_
21	of	of	IN	IN	_	24	case	_	_
22	other	other	JJ	JJ	_	24	amod	_	_
23	Pax	pax	NN	NN	_	24	compound	_	_
24	genes	gene	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	6	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	review	review	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	discuss	discuss	VBP	VBP	_	0	root	_	_
7	different	different	JJ	JJ	_	8	amod	_	_
8	models	model	NNS	NNS	_	6	dobj	_	_
9	accounting	account	VBG	VBG	_	8	acl	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	haploinsufficiency	haploinsufficiency	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	mammalian	mammalian	JJ	JJ	_	16	amod	_	_
15	Pax	pax	NN	NN	_	16	compound	_	_
16	genes	gene	NNS	NNS	_	12	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	provide	provide	VBP	VBP	_	6	conj	_	_
19	further	further	JJ	JJ	_	20	amod	_	_
20	evidence	evidence	NN	NN	_	18	dobj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	support	support	NN	NN	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	allele-specific	allele-specific	JJ	JJ	_	26	amod	_	_
26	regulation	regulation	NN	NN	_	22	nmod	_	_
27	of	of	IN	IN	_	28	case	_	_
28	Pax5	pax5	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	6	cc	_	_
30	discuss	discuss	VBP	VBP	_	6	conj	_	_
31	the	the	DT	DT	_	32	det	_	_
32	implication	implication	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	35	case	_	_
34	these	these	DT	DT	_	35	det	_	_
35	findings	finding	NNS	NNS	_	32	nmod	_	_
36	in	in	IN	IN	_	38	case	_	_
37	the	the	DT	DT	_	38	det	_	_
38	context	context	NN	NN	_	35	nmod	_	_
39	of	of	IN	IN	_	42	case	_	_
40	the	the	DT	DT	_	42	det	_	_
41	recent	recent	JJ	JJ	_	42	amod	_	_
42	literature	literature	NN	NN	_	38	nmod	_	_
43	describing	describe	VBG	VBG	_	42	acl	_	_
44	the	the	DT	DT	_	48	det	_	_
45	stochastic	stochastic	JJ	JJ	_	48	amod	_	_
46	and	and	CC	CC	_	45	cc	_	_
47	monoallelic	monoallelic	JJ	JJ	_	45	conj	_	_
48	activation	activation	NN	NN	_	43	dobj	_	_
49	of	of	IN	IN	_	52	case	_	_
50	other	other	JJ	JJ	_	52	amod	_	_
51	hematopoietic	hematopoietic	JJ	JJ	_	52	amod	_	_
52	genes	gene	NNS	NNS	_	48	nmod	_	_
53	.	.	.	.	_	6	punct	_	_

1	NF-kappaB-mediated	nf-kappab-mediated	JJ	JJ	_	2	amod	_	_
2	up-regulation	up-regulation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Bcl-x	bcl-x	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	Bfl-1/A1	bfl-1/a1	NN	NN	_	4	conj	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	required	require	VBN	VBN	_	0	root	_	_
9	for	for	IN	IN	_	11	case	_	_
10	CD40	cd40	NN	NN	_	11	compound	_	_
11	survival	survival	NN	NN	_	8	nmod	_	_
12	signaling	signal	VBG	VBG	_	11	amod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	B	b	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	11	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	Activation	activation	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	CD40	cd40	NN	NN	_	1	nmod	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	10	case	_	_
7	thymus-dependent	thymus-dependent	JJ	JJ	_	10	amod	_	_
8	humoral	humoral	JJ	JJ	_	10	amod	_	_
9	immune	immune	JJ	JJ	_	10	amod	_	_
10	responses	response	NNS	NNS	_	5	nmod	_	_
11	and	and	CC	CC	_	5	cc	_	_
12	rescuing	rescue	VBG	VBG	_	5	conj	_	_
13	B	b	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	12	dobj	_	_
15	from	from	IN	IN	_	16	case	_	_
16	apoptosis	apoptosis	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	Many	many	JJ	JJ	_	8	nsubjpass	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	effects	effect	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	CD40	cd40	NN	NN	_	4	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	believed	believe	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	achieved	achieve	VBN	VBN	_	8	xcomp	_	_
12	through	through	IN	IN	_	15	case	_	_
13	altered	altered	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	13	nmod	_	_
3	to	to	TO	TO	_	4	case	_	_
4	Bcl-x	bcl-x	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	a	a	DT	DT	_	10	det	_	_
7	known	known	JJ	JJ	_	10	amod	_	_
8	CD40-regulated	cd40-regulated	JJ	JJ	_	10	amod	_	_
9	antiapoptotic	antiapoptotic	JJ	JJ	_	10	amod	_	_
10	molecule	molecule	NN	NN	_	4	appos	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	identified	identify	VBD	VBD	_	0	root	_	_
14	a	a	DT	DT	_	17	det	_	_
15	related	related	JJ	JJ	_	17	amod	_	_
16	antiapoptotic	antiapoptotic	JJ	JJ	_	17	amod	_	_
17	molecule	molecule	NN	NN	_	13	dobj	_	_
18	,	,	,	,	_	17	punct	_	_
19	A1/Bfl-1	a1/bfl-1	NN	NN	_	17	appos	_	_
20	,	,	,	,	_	13	punct	_	_
21	as	as	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	CD40-inducible	cd40-inducible	JJ	JJ	_	24	amod	_	_
24	gene	gene	NN	NN	_	13	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Inhibition	inhibition	NN	NN	_	14	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	pathway	pathway	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	overexpression	overexpression	NN	NN	_	1	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	a	a	DT	DT	_	11	det	_	_
10	dominant-active	dominant-active	JJ	JJ	_	11	amod	_	_
11	inhibitor	inhibitor	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	11	nmod	_	_
14	abolished	abolish	VBD	VBD	_	0	root	_	_
15	CD40-induced	cd40-induced	JJ	JJ	_	16	amod	_	_
16	up-regulation	up-regulation	NN	NN	_	14	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	both	both	CC	CC	_	20	cc:preconj	_	_
19	the	the	DT	DT	_	20	dep	_	_
20	Bfl-1	bfl-1	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	Bcl-x	bcl-x	NN	NN	_	20	conj	_	_
23	genes	gene	NNS	NNS	_	20	dep	_	_
24	and	and	CC	CC	_	14	cc	_	_
25	also	also	RB	RB	_	26	advmod	_	_
26	eliminated	eliminate	VBD	VBD	_	14	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	ability	ability	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	30	case	_	_
30	CD40	cd40	NN	NN	_	28	nmod	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	rescue	rescue	VB	VB	_	26	advcl	_	_
33	Fas-induced	fas-induced	JJ	JJ	_	35	amod	_	_
34	cell	cell	NN	NN	_	35	compound	_	_
35	death	death	NN	NN	_	32	dobj	_	_
36	.	.	.	.	_	14	punct	_	_

1	Within	within	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	upstream	upstream	JJ	JJ	_	5	amod	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	region	region	NN	NN	_	14	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Bcl-x	bcl-x	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	14	punct	_	_
9	a	a	DT	DT	_	12	det	_	_
10	potential	potential	JJ	JJ	_	12	amod	_	_
11	NF-kappaB-binding	nf-kappab-binding	JJ	JJ	_	12	amod	_	_
12	sequence	sequence	NN	NN	_	14	nsubjpass	_	_
13	was	be	VBD	VBD	_	14	auxpass	_	_
14	found	find	VBN	VBN	_	0	root	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	support	support	VB	VB	_	14	xcomp	_	_
17	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	14	punct	_	_

1	Furthermore	furthermore	RB	RB	_	3	advmod	_	_
2	,	,	,	,	_	3	punct	_	_
3	expression	expression	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	physiological	physiological	JJ	JJ	_	6	amod	_	_
6	levels	level	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	Bcl-x	bcl-x	NN	NN	_	11	compound	_	_
9	protected	protect	VBD	VBD	_	11	amod	_	_
10	B	b	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	6	nmod	_	_
12	from	from	IN	IN	_	14	case	_	_
13	Fas-mediated	fas-mediated	JJ	JJ	_	14	amod	_	_
14	apoptosis	apoptosis	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	absence	absence	NN	NN	_	14	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	20	compound	_	_
20	signaling	signaling	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	Thus	thus	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	results	result	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	CD40-mediated	cd40-mediated	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	survival	survival	NN	NN	_	10	nsubj	_	_
10	proceeds	proceed	VBZ	VBZ	_	5	ccomp	_	_
11	through	through	IN	IN	_	13	case	_	_
12	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	13	amod	_	_
13	up-regulation	up-regulation	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	Bcl-2	bcl-2	NN	NN	_	17	compound	_	_
16	family	family	NN	NN	_	17	compound	_	_
17	members	member	NNS	NNS	_	13	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Distinctive	distinctive	JJ	JJ	_	4	amod	_	_
2	gene	gene	NN	NN	_	4	compound	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	patterns	pattern	NNS	NNS	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	mammary	mammary	JJ	JJ	_	9	amod	_	_
8	epithelial	epithelial	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	4	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	breast	breast	NN	NN	_	12	compound	_	_
12	cancers	cancer	NNS	NNS	_	9	conj	_	_
13	.	.	.	.	_	4	punct	_	_

1	cDNA	cdna	NN	NN	_	2	compound	_	_
2	microarrays	microarray	NNS	NNS	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	a	a	DT	DT	_	6	det	_	_
5	clustering	clustering	NN	NN	_	6	compound	_	_
6	algorithm	algorithm	NN	NN	_	2	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	used	use	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	identify	identify	VB	VB	_	8	xcomp	_	_
11	patterns	pattern	NNS	NNS	_	10	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	human	human	JJ	JJ	_	19	amod	_	_
17	mammary	mammary	JJ	JJ	_	19	amod	_	_
18	epithelial	epithelial	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	growing	grow	VBG	VBG	_	19	acl	_	_
21	in	in	IN	IN	_	22	case	_	_
22	culture	culture	NN	NN	_	20	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	in	in	IN	IN	_	28	case	_	_
25	primary	primary	JJ	JJ	_	28	amod	_	_
26	human	human	JJ	JJ	_	28	amod	_	_
27	breast	breast	NN	NN	_	28	compound	_	_
28	tumors	tumor	NNS	NNS	_	22	conj	_	_
29	.	.	.	.	_	8	punct	_	_

1	Clusters	cluster	NNS	NNS	_	15	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	coexpressed	coexpress	VBN	VBN	_	4	amod	_	_
4	genes	gene	NNS	NNS	_	1	nmod	_	_
5	identified	identify	VBN	VBN	_	4	acl	_	_
6	through	through	IN	IN	_	7	case	_	_
7	manipulations	manipulation	NNS	NNS	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	mammary	mammary	JJ	JJ	_	11	amod	_	_
10	epithelial	epithelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	in	in	FW	FW	_	13	compound	_	_
13	vitro	vitro	FW	FW	_	7	advmod	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	consistent	consistent	JJ	JJ	_	17	amod	_	_
17	patterns	pattern	NNS	NNS	_	15	dobj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	variation	variation	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	21	case	_	_
21	expression	expression	NN	NN	_	19	nmod	_	_
22	among	among	IN	IN	_	25	case	_	_
23	breast	breast	NN	NN	_	25	compound	_	_
24	tumor	tumor	NN	NN	_	25	compound	_	_
25	samples	sample	NNS	NNS	_	19	nmod	_	_
26	.	.	.	.	_	15	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	36	advcl	_	_
3	immunohistochemistry	immunohistochemistry	NN	NN	_	2	dobj	_	_
4	with	with	IN	IN	_	5	case	_	_
5	antibodies	antibody	NNS	NNS	_	3	nmod	_	_
6	against	against	IN	IN	_	7	case	_	_
7	proteins	protein	NNS	NNS	_	5	nmod	_	_
8	encoded	encode	VBN	VBN	_	7	acl	_	_
9	by	by	IN	IN	_	12	case	_	_
10	a	a	DT	DT	_	12	det	_	_
11	particular	particular	JJ	JJ	_	12	amod	_	_
12	gene	gene	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	cluster	cluster	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	36	punct	_	_
17	the	the	DT	DT	_	18	det	_	_
18	identity	identity	NN	NN	_	36	nsubjpass	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	type	type	NN	NN	_	18	nmod	_	_
23	within	within	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	tumor	tumor	NN	NN	_	26	compound	_	_
26	specimen	specimen	NN	NN	_	22	nmod	_	_
27	that	that	WDT	WDT	_	28	nsubj	_	_
28	contributed	contribute	VBD	VBD	_	26	acl:relcl	_	_
29	the	the	DT	DT	_	33	det	_	_
30	observed	observe	VBN	VBN	_	33	amod	_	_
31	gene	gene	NN	NN	_	33	compound	_	_
32	expression	expression	NN	NN	_	33	compound	_	_
33	pattern	pattern	NN	NN	_	28	dobj	_	_
34	could	could	MD	MD	_	36	aux	_	_
35	be	be	VB	VB	_	36	auxpass	_	_
36	determined	determine	VBN	VBN	_	0	root	_	_
37	.	.	.	.	_	36	punct	_	_

1	Clusters	cluster	NNS	NNS	_	19	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	genes	gene	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	7	case	_	_
5	coherent	coherent	JJ	JJ	_	7	amod	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	patterns	pattern	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	cultured	culture	VBN	VBN	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	1	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	in	in	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	breast	breast	NN	NN	_	16	compound	_	_
15	tumors	tumor	NNS	NNS	_	16	compound	_	_
16	samples	sample	NNS	NNS	_	10	conj	_	_
17	could	could	MD	MD	_	19	aux	_	_
18	be	be	VB	VB	_	19	aux	_	_
19	related	related	JJ	JJ	_	0	root	_	_
20	to	to	TO	TO	_	22	case	_	_
21	specific	specific	JJ	JJ	_	22	amod	_	_
22	features	feature	NNS	NNS	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	biological	biological	JJ	JJ	_	25	amod	_	_
25	variation	variation	NN	NN	_	22	nmod	_	_
26	among	among	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	samples	sample	NNS	NNS	_	25	nmod	_	_
29	.	.	.	.	_	19	punct	_	_

1	Two	two	CD	CD	_	3	nummod	_	_
2	such	such	JJ	JJ	_	3	amod	_	_
3	clusters	cluster	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	found	find	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	have	have	VB	VB	_	5	xcomp	_	_
8	patterns	pattern	NNS	NNS	_	7	dobj	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	correlated	correlate	VBD	VBD	_	8	acl:relcl	_	_
11	with	with	IN	IN	_	12	case	_	_
12	variation	variation	NN	NN	_	10	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	cell	cell	NN	NN	_	16	compound	_	_
15	proliferation	proliferation	NN	NN	_	16	compound	_	_
16	rates	rate	NNS	NNS	_	12	nmod	_	_
17	and	and	CC	CC	_	12	cc	_	_
18	with	with	IN	IN	_	19	case	_	_
19	activation	activation	NN	NN	_	12	conj	_	_
20	of	of	IN	IN	_	25	case	_	_
21	the	the	DT	DT	_	25	det	_	_
22	IFN-regulated	ifn-regulated	JJ	JJ	_	25	amod	_	_
23	signal	signal	NN	NN	_	25	compound	_	_
24	transduction	transduction	NN	NN	_	25	compound	_	_
25	pathway	pathway	NN	NN	_	19	nmod	_	_
26	,	,	,	,	_	10	punct	_	_
27	respectively	respectively	RB	RB	_	10	advmod	_	_
28	.	.	.	.	_	5	punct	_	_

1	Clusters	cluster	NNS	NNS	_	16	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	genes	gene	NNS	NNS	_	1	nmod	_	_
4	expressed	express	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	stromal	stromal	JJ	JJ	_	7	amod	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	conj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	breast	breast	NN	NN	_	13	compound	_	_
13	tumors	tumor	NNS	NNS	_	7	nmod	_	_
14	also	also	RB	RB	_	16	advmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	identified	identify	VBN	VBN	_	0	root	_	_
17	in	in	IN	IN	_	19	case	_	_
18	this	this	DT	DT	_	19	det	_	_
19	analysis	analysis	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	16	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	support	support	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	feasibility	feasibility	NN	NN	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	usefulness	usefulness	NN	NN	_	5	conj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	this	this	DT	DT	_	11	det	_	_
10	systematic	systematic	JJ	JJ	_	11	amod	_	_
11	approach	approach	NN	NN	_	5	nmod	_	_
12	to	to	TO	TO	_	13	mark	_	_
13	studying	study	VBG	VBG	_	11	acl	_	_
14	variation	variation	NN	NN	_	13	dobj	_	_
15	in	in	IN	IN	_	18	case	_	_
16	gene	gene	NN	NN	_	18	compound	_	_
17	expression	expression	NN	NN	_	18	compound	_	_
18	patterns	pattern	NNS	NNS	_	14	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	human	human	JJ	JJ	_	21	amod	_	_
21	cancers	cancer	NNS	NNS	_	18	nmod	_	_
22	as	as	IN	IN	_	24	case	_	_
23	a	a	DT	DT	_	24	det	_	_
24	means	means	NN	NN	_	13	nmod	_	_
25	to	to	TO	TO	_	26	mark	_	_
26	dissect	dissect	VB	VB	_	24	acl	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	classify	classify	VB	VB	_	26	conj	_	_
29	solid	solid	JJ	JJ	_	30	amod	_	_
30	tumors	tumor	NNS	NNS	_	26	dobj	_	_
31	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	6	amod	_	_
3	virus	virus	NN	NN	_	6	compound	_	_
4	latency	latency	NN	NN	_	6	compound	_	_
5	BamHI-Q	bamhi-q	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	positively	positively	RB	RB	_	9	advmod	_	_
9	regulated	regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	STATs	stats	NNS	NNS	_	9	nmod	_	_
12	and	and	CC	CC	_	9	cc	_	_
13	Zta	zta	NN	NN	_	14	compound	_	_
14	interference	interference	NN	NN	_	18	nsubj	_	_
15	with	with	IN	IN	_	17	case	_	_
16	JAK/STAT	jak/stat	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	14	nmod	_	_
18	leads	lead	VBZ	VBZ	_	9	conj	_	_
19	to	to	TO	TO	_	20	case	_	_
20	loss	loss	NN	NN	_	18	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	BamHI-Q	bamhi-q	NN	NN	_	24	compound	_	_
23	promoter	promoter	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	8	case	_	_
2	Epstein-Barr	epstein-barr	JJ	JJ	_	3	amod	_	_
3	virus	virus	NN	NN	_	8	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBV	ebv	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-associated	-associated	JJ	JJ	_	8	amod	_	_
8	tumors	tumor	NNS	NNS	_	18	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	nonimmunocompromised	nonimmunocompromised	JJ	JJ	_	11	amod	_	_
11	patients	patient	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	18	punct	_	_
13	EBV	ebv	NN	NN	_	15	compound	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	expression	expression	NN	NN	_	18	nsubj	_	_
16	is	be	VBZ	VBZ	_	18	aux	_	_
17	highly	highly	RB	RB	_	18	advmod	_	_
18	restricted	restricted	JJ	JJ	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	EBV-encoded	ebv-encoded	JJ	JJ	_	3	amod	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	antigen	antigen	NN	NN	_	9	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EBNA	ebna	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	-1	-1	CD	CD	_	3	nummod	_	_
8	is	be	VBZ	VBZ	_	9	auxpass	_	_
9	expressed	express	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	whereas	whereas	IN	IN	_	9	dep	_	_
12	the	the	DT	DT	_	16	det	_	_
13	immunogenic	immunogenic	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	proliferative	proliferative	JJ	JJ	_	13	conj	_	_
16	EBNAs	ebna	NNS	NNS	_	17	nsubj	_	_
17	are	be	VBP	VBP	_	9	parataxis	_	_
18	not	not	RB	RB	_	17	neg	_	_
19	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	pattern	pattern	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	EBNA	ebna	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	generated	generate	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	case	_	_
9	usage	usage	NN	NN	_	7	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	BamHI-Q	bamhi-q	NN	NN	_	13	compound	_	_
13	promoter	promoter	NN	NN	_	9	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	Qp	qp	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	.	.	.	.	_	7	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	determined	determine	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	JAK/STAT	jak/stat	JJ	JJ	_	7	amod	_	_
7	pathway	pathway	NN	NN	_	9	nsubj	_	_
8	positively	positively	RB	RB	_	9	advmod	_	_
9	regulates	regulate	VBZ	VBZ	_	3	ccomp	_	_
10	Qp	qp	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	9	dobj	_	_
12	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	transient-transfection	transient-transfection	JJ	JJ	_	3	amod	_	_
3	assays	assay	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	Qp-CAT	qp-cat	NN	NN	_	7	compound	_	_
7	reporter	reporter	NN	NN	_	9	nsubjpass	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	activated	activate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	cotransfected	cotransfect	VBN	VBN	_	12	amod	_	_
12	JAK-1	jak-1	NN	NN	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	by	by	IN	IN	_	15	case	_	_
15	treatment	treatment	NN	NN	_	12	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cytokine	cytokine	NN	NN	_	17	nmod	_	_
21	IL-6	il-6	NN	NN	_	20	dep	_	_
22	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	ability	ability	NN	NN	_	19	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Qp	qp	NN	NN	_	2	nmod	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	bind	bind	VB	VB	_	2	acl	_	_
7	signal	signal	NN	NN	_	8	compound	_	_
8	transducer	transducer	NN	NN	_	16	compound	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	activator	activator	NN	NN	_	12	compound	_	_
11	of	of	IN	IN	_	12	amod	_	_
12	transcription	transcription	NN	NN	_	8	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	STAT	stat	NN	NN	_	8	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	proteins	protein	NNS	NNS	_	6	dobj	_	_
17	was	be	VBD	VBD	_	19	auxpass	_	_
18	directly	directly	RB	RB	_	19	advmod	_	_
19	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	23	case	_	_
21	electrophoretic	electrophoretic	JJ	JJ	_	23	amod	_	_
22	mobility-shift	mobility-shift	JJ	JJ	_	23	amod	_	_
23	assay	assay	NN	NN	_	19	nmod	_	_
24	,	,	,	,	_	19	punct	_	_
25	and	and	CC	CC	_	19	cc	_	_
26	mutation	mutation	NN	NN	_	31	nsubj	_	_
27	of	of	IN	IN	_	30	case	_	_
28	potential	potential	JJ	JJ	_	30	amod	_	_
29	STAT-binding	stat-binding	JJ	JJ	_	30	amod	_	_
30	sites	site	NNS	NNS	_	26	nmod	_	_
31	reduced	reduce	VBD	VBD	_	19	conj	_	_
32	Qp	qp	NN	NN	_	33	compound	_	_
33	responsiveness	responsiveness	NN	NN	_	31	dobj	_	_
34	to	to	TO	TO	_	36	case	_	_
35	Janus	janus	NN	NN	_	36	compound	_	_
36	kinase	kinase	NN	NN	_	33	nmod	_	_
37	(	(	-LRB-	-LRB-	_	38	punct	_	_
38	JAK	jak	NN	NN	_	36	appos	_	_
39	)	)	-RRB-	-RRB-	_	38	punct	_	_
40	-1	-1	CD	CD	_	36	nummod	_	_
41	.	.	.	.	_	19	punct	_	_

1	Consistent	consistent	JJ	JJ	_	26	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	a	a	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	for	for	IN	IN	_	6	case	_	_
6	STATs	stats	NNS	NNS	_	4	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	Qp	qp	NN	NN	_	9	compound	_	_
9	function	function	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	26	punct	_	_
11	Qp	qp	NN	NN	_	26	nsubj	_	_
12	using	use	VBG	VBG	_	11	acl	_	_
13	Burkitt	burkitt	NN	NN	_	17	nmod:poss	_	_
14	's	's	POS	POS	_	17	case	_	_
15	lymphoma	lymphoma	NN	NN	_	17	compound	_	_
16	Rael	rael	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	dobj	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	cultured	culture	VBN	VBN	_	25	amod	_	_
20	nasopharyngeal	nasopharyngeal	NN	NN	_	21	compound	_	_
21	carcinoma	carcinoma	NN	NN	_	25	compound	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	NPC	npc	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	cells	cell	NNS	NNS	_	17	conj	_	_
26	contained	contain	VBD	VBD	_	0	root	_	_
27	nuclear	nuclear	JJ	JJ	_	29	amod	_	_
28	STAT	stat	NN	NN	_	29	compound	_	_
29	protein	protein	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	26	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	whether	whether	IN	IN	_	15	mark	_	_
4	the	the	DT	DT	_	5	det	_	_
5	inability	inability	NN	NN	_	15	nsubj	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	maintain	maintain	VB	VB	_	5	acl	_	_
8	EBV-positive	ebv-positive	JJ	JJ	_	11	amod	_	_
9	NPC	npc	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	lines	line	NNS	NNS	_	7	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	culture	culture	NN	NN	_	11	nmod	_	_
14	was	be	VBD	VBD	_	15	aux	_	_
15	related	related	JJ	JJ	_	2	ccomp	_	_
16	to	to	TO	TO	_	18	case	_	_
17	Qp	qp	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Passaging	passaging	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	NPC	npc	NN	NN	_	7	compound	_	_
5	cell	cell	NN	NN	_	7	compound	_	_
6	line	line	NN	NN	_	7	compound	_	_
7	HK666	hk666	NN	NN	_	1	nmod	_	_
8	led	lead	VBD	VBD	_	0	root	_	_
9	to	to	TO	TO	_	10	case	_	_
10	activation	activation	NN	NN	_	8	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	expression	expression	NN	NN	_	10	nmod	_	_
13	of	of	IN	IN	_	14	case	_	_
14	BZLF1	bzlf1	NN	NN	_	12	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	17	nsubj	_	_
17	encodes	encode	VBZ	VBZ	_	14	acl:relcl	_	_
18	Zta	zta	NN	NN	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	loss	loss	NN	NN	_	18	conj	_	_
21	of	of	IN	IN	_	23	case	_	_
22	Qp	qp	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	8	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	expression	expression	NN	NN	_	3	compound	_	_
3	assays	assay	NNS	NNS	_	4	nsubj	_	_
4	linked	link	VBD	VBD	_	0	root	_	_
5	Zta	zta	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	4	dobj	_	_
7	to	to	TO	TO	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	down-regulation	down-regulation	NN	NN	_	4	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	Qp	qp	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	4	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	4	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	Zta	zta	NN	NN	_	1	nmod	_	_
4	reduced	reduce	VBD	VBD	_	0	root	_	_
5	Qp	qp	NN	NN	_	6	compound	_	_
6	activity	activity	NN	NN	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	reporter	reporter	NN	NN	_	9	compound	_	_
9	assays	assay	NNS	NNS	_	4	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	negative	negative	JJ	JJ	_	3	amod	_	_
3	regulation	regulation	NN	NN	_	4	nsubj	_	_
4	required	require	VBD	VBD	_	0	root	_	_
5	Zta	zta	NN	NN	_	7	compound	_	_
6	DNA-binding	dna-binding	JJ	JJ	_	7	amod	_	_
7	activity	activity	NN	NN	_	4	dobj	_	_
8	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	provide	provide	VBP	VBP	_	0	root	_	_
3	evidence	evidence	NN	NN	_	2	dobj	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	Zta	zta	NN	NN	_	6	compound	_	_
6	up-regulation	up-regulation	NN	NN	_	9	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	p53	p53	NN	NN	_	6	nmod	_	_
9	leads	lead	VBZ	VBZ	_	3	dep	_	_
10	to	to	TO	TO	_	12	case	_	_
11	p53-mediated	p53-mediated	JJ	JJ	_	12	amod	_	_
12	interference	interference	NN	NN	_	9	nmod	_	_
13	with	with	IN	IN	_	15	case	_	_
14	JAK/STAT	jak/stat	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	Qp	qp	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	imply	imply	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	JAK/STAT	jak/stat	JJ	JJ	_	6	amod	_	_
6	signaling	signaling	NN	NN	_	7	nsubj	_	_
7	has	have	VBZ	VBZ	_	3	ccomp	_	_
8	a	a	DT	DT	_	9	det	_	_
9	role	role	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	EBV-associated	ebv-associated	JJ	JJ	_	12	amod	_	_
12	malignancies	malignancy	NNS	NNS	_	9	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Bcl-2-mediated	bcl-2-mediated	JJ	JJ	_	3	amod	_	_
2	drug	drug	NN	NN	_	3	compound	_	_
3	resistance	resistance	NN	NN	_	0	root	_	_
4	:	:	:	:	_	3	punct	_	_
5	inhibition	inhibition	NN	NN	_	3	dep	_	_
6	of	of	IN	IN	_	7	case	_	_
7	apoptosis	apoptosis	NN	NN	_	5	nmod	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	blocking	block	VBG	VBG	_	5	acl	_	_
10	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
11	factor	factor	NN	NN	_	15	compound	_	_
12	of	of	IN	IN	_	15	amod	_	_
13	activated	activate	VBN	VBN	_	15	amod	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	22	compound	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	NFAT	nfat	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	-induced	-induced	JJ	JJ	_	22	amod	_	_
20	Fas	fas	NN	NN	_	22	compound	_	_
21	ligand	ligand	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	9	dobj	_	_
23	.	.	.	.	_	3	punct	_	_

1	Bcl-2	bcl-2	NN	NN	_	2	nsubj	_	_
2	inhibits	inhibit	VBZ	VBZ	_	0	root	_	_
3	apoptosis	apoptosis	NN	NN	_	2	dobj	_	_
4	induced	induce	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	variety	variety	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	stimuli	stimulus	NNS	NNS	_	7	nmod	_	_
10	,	,	,	,	_	7	punct	_	_
11	including	include	VBG	VBG	_	13	case	_	_
12	chemotherapy	chemotherapy	NN	NN	_	13	compound	_	_
13	drugs	drug	NNS	NNS	_	7	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	glucocorticoids	glucocorticoid	NNS	NNS	_	13	conj	_	_
16	.	.	.	.	_	2	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	generally	generally	RB	RB	_	4	advmod	_	_
4	accepted	accept	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	Bcl-2	bcl-2	NN	NN	_	7	nsubj	_	_
7	exerts	exert	VBZ	VBZ	_	4	ccomp	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	antiapoptotic	antiapoptotic	JJ	JJ	_	10	amod	_	_
10	effects	effect	NNS	NNS	_	7	dobj	_	_
11	mainly	mainly	RB	RB	_	13	advmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	dimerizing	dimerize	VBG	VBG	_	7	advcl	_	_
14	with	with	IN	IN	_	16	case	_	_
15	proapoptotic	proapoptotic	JJ	JJ	_	16	amod	_	_
16	members	member	NNS	NNS	_	13	nmod	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	Bcl-2	bcl-2	NN	NN	_	20	compound	_	_
20	family	family	NN	NN	_	16	nmod	_	_
21	such	such	JJ	JJ	_	23	case	_	_
22	as	as	IN	IN	_	21	mwe	_	_
23	Bax	bax	NN	NN	_	20	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	Bad	bad	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	10	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	antiapoptotic	antiapoptotic	JJ	JJ	_	8	amod	_	_
8	effects	effect	NNS	NNS	_	4	nmod	_	_
9	is	be	VBZ	VBZ	_	10	cop	_	_
10	unclear	unclear	JJ	JJ	_	0	root	_	_
11	.	.	.	.	_	10	punct	_	_

1	Paclitaxel	paclitaxel	NN	NN	_	9	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	drugs	drug	NNS	NNS	_	1	conj	_	_
5	that	that	WDT	WDT	_	6	nsubj	_	_
6	disturb	disturb	VBP	VBP	_	1	acl:relcl	_	_
7	microtubule	microtubule	NN	NN	_	8	compound	_	_
8	dynamics	dynamics	NNS	NNS	_	6	dobj	_	_
9	kill	kill	VBP	VBP	_	0	root	_	_
10	cells	cell	NNS	NNS	_	9	dobj	_	_
11	in	in	IN	IN	_	21	case	_	_
12	a	a	DT	DT	_	21	det	_	_
13	Fas	fas	NN	NN	_	21	compound	_	_
14	/	/	:	:	_	13	punct	_	_
15	Fas	fas	NN	NN	_	16	compound	_	_
16	ligand	ligand	NN	NN	_	13	dep	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	FasL	fasl	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	-dependent	-dependent	JJ	JJ	_	21	amod	_	_
21	manner	manner	NN	NN	_	9	nmod	_	_
22	;	;	:	:	_	9	punct	_	_
23	antibody	antibody	NN	NN	_	26	nsubj	_	_
24	to	to	TO	TO	_	25	case	_	_
25	FasL	fasl	NN	NN	_	23	nmod	_	_
26	inhibits	inhibit	VBZ	VBZ	_	9	parataxis	_	_
27	paclitaxel-induced	paclitaxel-induced	JJ	JJ	_	28	amod	_	_
28	apoptosis	apoptosis	NN	NN	_	26	dobj	_	_
29	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	Bcl-2	bcl-2	NN	NN	_	6	compound	_	_
6	overexpression	overexpression	NN	NN	_	7	nsubj	_	_
7	leads	lead	VBZ	VBZ	_	3	ccomp	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	prevention	prevention	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	17	case	_	_
12	chemotherapy	chemotherapy	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	paclitaxel	paclitaxel	NN	NN	_	17	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	-induced	-induced	JJ	JJ	_	17	amod	_	_
17	expression	expression	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	FasL	fasl	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	blocks	block	VBZ	VBZ	_	7	conj	_	_
22	paclitaxel-induced	paclitaxel-induced	JJ	JJ	_	23	amod	_	_
23	apoptosis	apoptosis	NN	NN	_	21	dobj	_	_
24	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	mechanism	mechanism	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	0	root	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	Bcl-2	bcl-2	NN	NN	_	9	nsubj	_	_
9	prevents	prevent	VBZ	VBZ	_	6	ccomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	nuclear	nuclear	JJ	JJ	_	12	amod	_	_
12	translocation	translocation	NN	NN	_	9	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	NFAT	nfat	NN	NN	_	12	nmod	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
17	factor	factor	NN	NN	_	21	compound	_	_
18	of	of	IN	IN	_	21	amod	_	_
19	activated	activate	VBN	VBN	_	21	amod	_	_
20	T	t	NN	NN	_	21	compound	_	_
21	lymphocytes	lymphocyte	NNS	NNS	_	14	dep	_	_
22	,	,	,	,	_	21	punct	_	_
23	a	a	DT	DT	_	25	det	_	_
24	transcription	transcription	NN	NN	_	25	compound	_	_
25	factor	factor	NN	NN	_	21	appos	_	_
26	activated	activate	VBN	VBN	_	25	acl	_	_
27	by	by	IN	IN	_	29	case	_	_
28	microtubule	microtubule	JJ	JJ	_	29	amod	_	_
29	damage	damage	NN	NN	_	26	nmod	_	_
30	)	)	-RRB-	-RRB-	_	21	punct	_	_
31	by	by	IN	IN	_	32	mark	_	_
32	binding	bind	VBG	VBG	_	9	advcl	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	sequestering	sequester	VBG	VBG	_	32	conj	_	_
35	calcineurin	calcineurin	NN	NN	_	32	dobj	_	_
36	,	,	,	,	_	35	punct	_	_
37	a	a	DT	DT	_	39	det	_	_
38	calcium-dependent	calcium-dependent	JJ	JJ	_	39	amod	_	_
39	phosphatase	phosphatase	NN	NN	_	35	appos	_	_
40	that	that	WDT	WDT	_	42	nsubj	_	_
41	must	must	MD	MD	_	42	aux	_	_
42	dephosphorylate	dephosphorylate	VB	VB	_	39	acl:relcl	_	_
43	NFAT	nfat	NN	NN	_	42	dobj	_	_
44	to	to	TO	TO	_	45	mark	_	_
45	move	move	VB	VB	_	42	advcl	_	_
46	to	to	TO	TO	_	48	case	_	_
47	the	the	DT	DT	_	48	det	_	_
48	nucleus	nucleus	NN	NN	_	45	nmod	_	_
49	.	.	.	.	_	6	punct	_	_

1	Without	without	IN	IN	_	4	case	_	_
2	NFAT	nfat	NN	NN	_	4	compound	_	_
3	nuclear	nuclear	JJ	JJ	_	4	amod	_	_
4	translocation	translocation	NN	NN	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	FasL	fasl	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	transcribed	transcribe	VBN	VBN	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	Thus	thus	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	it	it	PRP	PRP	_	4	nsubj	_	_
4	appears	appear	VBZ	VBZ	_	0	root	_	_
5	that	that	IN	IN	_	14	mark	_	_
6	paclitaxel	paclitaxel	NN	NN	_	14	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	drugs	drug	NNS	NNS	_	6	conj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	disturb	disturb	VBP	VBP	_	6	acl:relcl	_	_
12	microtubule	microtubule	JJ	JJ	_	13	amod	_	_
13	function	function	NN	NN	_	11	dobj	_	_
14	kill	kill	VBP	VBP	_	4	ccomp	_	_
15	cells	cell	NNS	NNS	_	14	dobj	_	_
16	at	at	IN	IN	_	14	advmod	_	_
17	least	least	JJS	JJS	_	16	mwe	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	14	nmod	_	_
20	through	through	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	induction	induction	NN	NN	_	14	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	FasL	fasl	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	Bcl-2	bcl-2	NN	NN	_	4	nsubj	_	_
4	antagonizes	antagonize	VBZ	VBZ	_	0	root	_	_
5	drug-induced	drug-induced	JJ	JJ	_	6	amod	_	_
6	apoptosis	apoptosis	NN	NN	_	4	dobj	_	_
7	by	by	IN	IN	_	8	mark	_	_
8	inhibiting	inhibit	VBG	VBG	_	4	advcl	_	_
9	calcineurin	calcineurin	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	8	punct	_	_
12	blocking	block	VBG	VBG	_	8	conj	_	_
13	NFAT	nfat	NN	NN	_	15	compound	_	_
14	nuclear	nuclear	JJ	JJ	_	15	amod	_	_
15	translocation	translocation	NN	NN	_	12	dobj	_	_
16	,	,	,	,	_	8	punct	_	_
17	and	and	CC	CC	_	8	cc	_	_
18	preventing	prevent	VBG	VBG	_	8	conj	_	_
19	FasL	fasl	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	18	dobj	_	_
21	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	effects	effect	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Bcl-2	bcl-2	NN	NN	_	2	nmod	_	_
5	can	can	MD	MD	_	7	aux	_	_
6	be	be	VB	VB	_	7	auxpass	_	_
7	overcome	overcome	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	at	at	IN	IN	_	7	advmod	_	_
10	least	least	JJS	JJS	_	9	mwe	_	_
11	partially	partially	RB	RB	_	7	advmod	_	_
12	,	,	,	,	_	7	punct	_	_
13	through	through	IN	IN	_	14	case	_	_
14	phosphorylation	phosphorylation	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	Bcl-2	bcl-2	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	7	punct	_	_

1	Phosphorylated	phosphorylate	VBN	VBN	_	2	amod	_	_
2	Bcl-2	bcl-2	NN	NN	_	5	nsubj	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	not	not	RB	RB	_	5	neg	_	_
5	bind	bind	VB	VB	_	0	root	_	_
6	calcineurin	calcineurin	NN	NN	_	5	dobj	_	_
7	,	,	,	,	_	5	punct	_	_
8	and	and	CC	CC	_	5	cc	_	_
9	NFAT	nfat	NN	NN	_	10	compound	_	_
10	activation	activation	NN	NN	_	18	nsubj	_	_
11	,	,	,	,	_	10	punct	_	_
12	FasL	fasl	NN	NN	_	13	compound	_	_
13	expression	expression	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	10	punct	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	apoptosis	apoptosis	NN	NN	_	10	conj	_	_
17	can	can	MD	MD	_	18	aux	_	_
18	occur	occur	VB	VB	_	5	conj	_	_
19	after	after	IN	IN	_	21	case	_	_
20	Bcl-2	bcl-2	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	Selective	selective	JJ	JJ	_	3	amod	_	_
2	DNA-binding	dna-binding	JJ	JJ	_	3	amod	_	_
3	activity	activity	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	interleukin-10-stimulated	interleukin-10-stimulated	JJ	JJ	_	7	amod	_	_
6	STAT	stat	NN	NN	_	7	compound	_	_
7	molecules	molecule	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	human	human	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	15	mark	_	_
6	interferon-gamma	interferon-gamma	NN	NN	_	15	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	IFN-gamma	ifn-gamma	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	and	and	CC	CC	_	6	cc	_	_
11	interleukin-10	interleukin-10	NN	NN	_	6	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IL-10	il-10	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	have	have	VBP	VBP	_	4	ccomp	_	_
16	various	various	JJ	JJ	_	18	amod	_	_
17	reverse	reverse	JJ	JJ	_	18	amod	_	_
18	effects	effect	NNS	NNS	_	15	dobj	_	_
19	on	on	IN	IN	_	20	case	_	_
20	macrophages	macrophage	NNS	NNS	_	18	nmod	_	_
21	;	;	:	:	_	4	punct	_	_
22	however	however	RB	RB	_	34	advmod	_	_
23	,	,	,	,	_	34	punct	_	_
24	the	the	DT	DT	_	26	det	_	_
25	molecular	molecular	JJ	JJ	_	26	amod	_	_
26	mechanism	mechanism	NN	NN	_	34	nsubjpass	_	_
27	of	of	IN	IN	_	29	case	_	_
28	this	this	DT	DT	_	29	det	_	_
29	difference	difference	NN	NN	_	26	nmod	_	_
30	has	have	VBZ	VBZ	_	34	aux	_	_
31	not	not	RB	RB	_	34	neg	_	_
32	been	be	VBN	VBN	_	34	auxpass	_	_
33	fully	fully	RB	RB	_	34	advmod	_	_
34	understood	understand	VBN	VBN	_	4	parataxis	_	_
35	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	analyzed	analyze	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	binding	bind	VBG	VBG	_	9	amod	_	_
9	activity	activity	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	15	case	_	_
11	IL-10-	il-10-	NN	NN	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	11	conj	_	_
14	STAT	stat	NN	NN	_	15	compound	_	_
15	molecules	molecule	NNS	NNS	_	9	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	two	two	CD	CD	_	18	nummod	_	_
18	kinds	kind	NNS	NNS	_	6	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	GAS-motif	gas-motif	NN	NN	_	21	compound	_	_
21	sequences	sequence	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	IL-10-activated	il-10-activated	JJ	JJ	_	2	amod	_	_
2	STAT1	stat1	NN	NN	_	4	nsubj	_	_
3	could	could	MD	MD	_	4	aux	_	_
4	bind	bind	VB	VB	_	0	root	_	_
5	to	to	TO	TO	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	GAS-motif	gas-motif	JJ	JJ	_	8	amod	_	_
8	sequence	sequence	NN	NN	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	promoter	promoter	NN	NN	_	12	compound	_	_
12	region	region	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	Fcgamma	fcgamma	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	but	but	CC	CC	_	8	cc	_	_
19	not	not	RB	RB	_	21	neg	_	_
20	to	to	TO	TO	_	21	case	_	_
21	that	that	DT	DT	_	8	conj	_	_
22	in	in	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	promoter	promoter	JJ	JJ	_	25	amod	_	_
25	region	region	NN	NN	_	21	nmod	_	_
26	of	of	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	COX-2	cox-2	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	25	nmod	_	_
30	,	,	,	,	_	4	punct	_	_
31	whereas	whereas	IN	IN	_	4	dep	_	_
32	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	33	amod	_	_
33	STAT1	stat1	NN	NN	_	37	nsubj	_	_
34	and	and	CC	CC	_	33	cc	_	_
35	STAT5	stat5	NN	NN	_	33	conj	_	_
36	could	could	MD	MD	_	37	aux	_	_
37	bind	bind	VB	VB	_	4	parataxis	_	_
38	to	to	TO	TO	_	40	case	_	_
39	both	both	DT	DT	_	40	det	_	_
40	sequences	sequence	NNS	NNS	_	37	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	IL-10	il-10	NN	NN	_	2	nsubj	_	_
2	inhibited	inhibit	VBD	VBD	_	0	root	_	_
3	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	5	amod	_	_
4	STAT	stat	NN	NN	_	5	compound	_	_
5	activation	activation	NN	NN	_	2	dobj	_	_
6	without	without	IN	IN	_	9	case	_	_
7	newly	newly	RB	RB	_	9	advmod	_	_
8	synthesized	synthesize	VBN	VBN	_	9	amod	_	_
9	protein	protein	NN	NN	_	2	nmod	_	_
10	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	aspirin	aspirin	NN	NN	_	11	nsubj	_	_
6	,	,	,	,	_	5	punct	_	_
7	but	but	CC	CC	_	5	cc	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	dexamethasone	dexamethasone	NN	NN	_	5	conj	_	_
10	,	,	,	,	_	11	punct	_	_
11	suppressed	suppress	VBD	VBD	_	3	ccomp	_	_
12	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	14	amod	_	_
13	STAT	stat	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	dobj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	these	these	DT	DT	_	5	det	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	10	mark	_	_
8	IL-10-activated	il-10-activated	JJ	JJ	_	9	amod	_	_
9	STAT1	stat1	NN	NN	_	10	nsubj	_	_
10	has	have	VBZ	VBZ	_	6	ccomp	_	_
11	a	a	DT	DT	_	12	det	_	_
12	specificity	specificity	NN	NN	_	10	dobj	_	_
13	in	in	IN	IN	_	14	case	_	_
14	binding	bind	VBG	VBG	_	12	nmod	_	_
15	to	to	TO	TO	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	GAS-motif	gas-motif	JJ	JJ	_	18	amod	_	_
18	sequences	sequence	NNS	NNS	_	14	nmod	_	_
19	,	,	,	,	_	10	punct	_	_
20	whereas	whereas	IN	IN	_	10	dep	_	_
21	IFN-gamma-activated	ifn-gamma-activated	JJ	JJ	_	22	amod	_	_
22	STAT1	stat1	NN	NN	_	25	nsubj	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	STAT5	stat5	NN	NN	_	22	conj	_	_
25	have	have	VBP	VBP	_	10	parataxis	_	_
26	a	a	DT	DT	_	28	det	_	_
27	broader	broader	JJR	JJR	_	28	amod	_	_
28	spectrum	spectrum	NN	NN	_	25	dobj	_	_
29	in	in	IN	IN	_	30	case	_	_
30	binding	bind	VBG	VBG	_	28	nmod	_	_
31	to	to	TO	TO	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	GAS-motif	gas-motif	JJ	JJ	_	34	amod	_	_
34	sequences	sequence	NNS	NNS	_	30	nmod	_	_
35	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	3	nsubj	_	_
2	may	may	MD	MD	_	3	aux	_	_
3	explain	explain	VB	VB	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	difference	difference	NN	NN	_	3	dobj	_	_
6	between	between	IN	IN	_	7	case	_	_
7	IL-10	il-10	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IFN-gamma	ifn-gamma	NN	NN	_	7	conj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	biological	biological	JJ	JJ	_	12	amod	_	_
12	activity	activity	NN	NN	_	7	nmod	_	_
13	,	,	,	,	_	5	punct	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	inhibitory	inhibitory	JJ	JJ	_	17	amod	_	_
17	effect	effect	NN	NN	_	5	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-10	il-10	NN	NN	_	17	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	activities	activity	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	3	punct	_	_

1	Block	block	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	4	case	_	_
3	granulocytic	granulocytic	JJ	JJ	_	4	amod	_	_
4	differentiation	differentiation	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	32Dcl3	32dcl3	NN	NN	_	7	compound	_	_
7	cells	cell	NNS	NNS	_	4	nmod	_	_
8	by	by	IN	IN	_	11	case	_	_
9	AML1/ETO	aml1/eto	NN	NN	_	11	compound	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	MTG8	mtg8	NN	NN	_	1	nmod	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	but	but	CC	CC	_	11	cc	_	_
14	not	not	RB	RB	_	18	neg	_	_
15	by	by	IN	IN	_	18	case	_	_
16	highly	highly	RB	RB	_	18	advmod	_	_
17	expressed	express	VBN	VBN	_	16	dep	_	_
18	Bcl-2	bcl-2	NN	NN	_	11	conj	_	_
19	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	chimeric	chimeric	JJ	JJ	_	3	amod	_	_
3	gene	gene	NN	NN	_	16	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	AML1/ETO	aml1/eto	NN	NN	_	7	compound	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MTG8	mtg8	NN	NN	_	3	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	,	,	,	,	_	3	punct	_	_
10	generated	generate	VBN	VBN	_	3	acl	_	_
11	in	in	IN	IN	_	12	case	_	_
12	t(8;21)	t(8;21)	NN	NN	_	10	nmod	_	_
13	acute	acute	JJ	JJ	_	15	amod	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	leukemia	leukemia	NN	NN	_	12	dep	_	_
16	enhances	enhance	VBZ	VBZ	_	0	root	_	_
17	the	the	DT	DT	_	18	det	_	_
18	expression	expression	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	Bcl-2	bcl-2	NN	NN	_	18	nmod	_	_
21	.	.	.	.	_	16	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	evaluate	evaluate	VB	VB	_	31	advcl	_	_
3	whether	whether	IN	IN	_	9	mark	_	_
4	this	this	DT	DT	_	5	det	_	_
5	enhancement	enhancement	NN	NN	_	9	nsubj	_	_
6	is	be	VBZ	VBZ	_	9	cop	_	_
7	the	the	DT	DT	_	9	det	_	_
8	primary	primary	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	2	ccomp	_	_
10	of	of	IN	IN	_	11	case	_	_
11	AML1/ETO	aml1/eto	NN	NN	_	9	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	leukemogenesis	leukemogenesis	NN	NN	_	9	nmod	_	_
14	,	,	,	,	_	31	punct	_	_
15	effects	effect	NNS	NNS	_	31	nsubjpass	_	_
16	of	of	IN	IN	_	17	case	_	_
17	over-expression	over-expression	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	Bcl-2	bcl-2	NN	NN	_	17	nmod	_	_
20	in	in	IN	IN	_	26	case	_	_
21	the	the	DT	DT	_	26	det	_	_
22	murine	murine	JJ	JJ	_	26	amod	_	_
23	myeloid	myeloid	JJ	JJ	_	26	amod	_	_
24	precursor	precursor	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	line	line	NN	NN	_	19	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	32Dcl3	32dcl3	NN	NN	_	26	appos	_	_
29	,	,	,	,	_	31	punct	_	_
30	were	be	VBD	VBD	_	31	auxpass	_	_
31	examined	examine	VBN	VBN	_	0	root	_	_
32	.	.	.	.	_	31	punct	_	_

1	When	when	WRB	WRB	_	8	advmod	_	_
2	32Dcl3	32dcl3	NN	NN	_	3	compound	_	_
3	cells	cell	NNS	NNS	_	8	nsubjpass	_	_
4	expressing	express	VBG	VBG	_	3	acl	_	_
5	exogenous	exogenous	JJ	JJ	_	6	amod	_	_
6	Bcl-2	bcl-2	NN	NN	_	4	dobj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	induced	induce	VBN	VBN	_	18	advcl	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	differentiate	differentiate	VB	VB	_	8	xcomp	_	_
11	,	,	,	,	_	18	punct	_	_
12	the	the	DT	DT	_	13	det	_	_
13	onset	onset	NN	NN	_	18	nsubjpass	_	_
14	of	of	IN	IN	_	16	case	_	_
15	morphological	morphological	JJ	JJ	_	16	amod	_	_
16	differentiation	differentiation	NN	NN	_	13	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	delayed	delay	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	even	even	RB	RB	_	5	advmod	_	_
4	the	the	DT	DT	_	5	det	_	_
5	cells	cell	NNS	NNS	_	14	nsubj	_	_
6	expressing	express	VBG	VBG	_	5	acl	_	_
7	very	very	RB	RB	_	8	advmod	_	_
8	high	high	JJ	JJ	_	9	amod	_	_
9	levels	level	NNS	NNS	_	6	dobj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	exogenous	exogenous	JJ	JJ	_	12	amod	_	_
12	Bcl-2	bcl-2	NN	NN	_	9	nmod	_	_
13	eventually	eventually	RB	RB	_	14	advmod	_	_
14	underwent	undergo	VBD	VBD	_	0	root	_	_
15	differentiation	differentiation	NN	NN	_	14	dobj	_	_
16	without	without	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	significant	significant	JJ	JJ	_	19	amod	_	_
19	decrease	decrease	NN	NN	_	14	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	synthesis	synthesis	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	Bcl-2	bcl-2	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	14	punct	_	_

1	On	on	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	contrary	contrary	NN	NN	_	12	nmod	_	_
4	,	,	,	,	_	12	punct	_	_
5	32Dcl3	32dcl3	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	12	nsubj	_	_
7	stably	stably	RB	RB	_	6	advmod	_	_
8	expressing	express	VBG	VBG	_	6	acl	_	_
9	AML1/ETO	aml1/eto	NN	NN	_	8	dobj	_	_
10	were	be	VBD	VBD	_	12	cop	_	_
11	completely	completely	RB	RB	_	12	advmod	_	_
12	resistant	resistant	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	differentiation	differentiation	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	continued	continue	VBD	VBD	_	12	conj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	grow	grow	VB	VB	_	16	xcomp	_	_
19	in	in	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	presence	presence	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	G-CSF	g-csf	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	4	nsubj	_	_
3	are	be	VBP	VBP	_	4	cop	_	_
4	consistent	consistent	JJ	JJ	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	interpretation	interpretation	NN	NN	_	4	nmod	_	_
8	that	that	IN	IN	_	17	mark	_	_
9	stimulation	stimulation	NN	NN	_	17	nsubj	_	_
10	of	of	IN	IN	_	12	case	_	_
11	Bcl-2	bcl-2	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	is	be	VBZ	VBZ	_	17	cop	_	_
14	not	not	RB	RB	_	17	neg	_	_
15	the	the	DT	DT	_	17	det	_	_
16	primary	primary	JJ	JJ	_	17	amod	_	_
17	target	target	NN	NN	_	7	dep	_	_
18	of	of	IN	IN	_	19	case	_	_
19	AML1/ETO	aml1/eto	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Retinoblastoma	retinoblastoma	NN	NN	_	3	compound	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	leads	lead	VBZ	VBZ	_	0	root	_	_
5	to	to	TO	TO	_	10	case	_	_
6	reduced	reduce	VBN	VBN	_	10	amod	_	_
7	Oct-1	oct-1	NN	NN	_	10	compound	_	_
8	DNA	dna	NN	NN	_	10	compound	_	_
9	binding	binding	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	enhances	enhance	VBZ	VBZ	_	4	conj	_	_
13	interleukin-8	interleukin-8	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	lines	line	NNS	NNS	_	10	nsubj	_	_
4	with	with	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	defective	defective	JJ	JJ	_	8	amod	_	_
7	retinoblastoma	retinoblastoma	NN	NN	_	8	compound	_	_
8	gene	gene	NN	NN	_	3	nmod	_	_
9	are	be	VBP	VBP	_	10	cop	_	_
10	unable	unable	JJ	JJ	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	transcribe	transcribe	VB	VB	_	10	xcomp	_	_
13	the	the	DT	DT	_	17	det	_	_
14	HLA	hla	NN	NN	_	17	compound	_	_
15	class	class	NN	NN	_	17	compound	_	_
16	II	ii	CD	CD	_	17	nummod	_	_
17	genes	gene	NNS	NNS	_	12	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	response	response	NN	NN	_	12	nmod	_	_
20	to	to	TO	TO	_	22	case	_	_
21	IFN-gamma	ifn-gamma	NN	NN	_	22	compound	_	_
22	treatment	treatment	NN	NN	_	19	nmod	_	_
23	,	,	,	,	_	10	punct	_	_
24	and	and	CC	CC	_	10	cc	_	_
25	reconstitution	reconstitution	NN	NN	_	29	nsubj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	functional	functional	JJ	JJ	_	28	amod	_	_
28	Rb	rb	NN	NN	_	25	nmod	_	_
29	rescues	rescue	VBZ	VBZ	_	10	conj	_	_
30	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	34	amod	_	_
31	class	class	NN	NN	_	34	compound	_	_
32	II	ii	CD	CD	_	34	nummod	_	_
33	gene	gene	NN	NN	_	34	compound	_	_
34	expression	expression	NN	NN	_	29	dobj	_	_
35	.	.	.	.	_	10	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	the	the	DT	DT	_	5	det	_	_
4	molecular	molecular	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	15	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Rb	rb	NN	NN	_	8	compound	_	_
8	rescue	rescue	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	II	ii	CD	CD	_	13	nummod	_	_
13	genes	gene	NNS	NNS	_	8	nmod	_	_
14	is	be	VBZ	VBZ	_	15	aux	_	_
15	unknown	unknown	JJ	JJ	_	0	root	_	_
16	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	examined	examine	VBN	VBN	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	Rb	rb	NN	NN	_	8	compound	_	_
8	expression	expression	NN	NN	_	5	nmod	_	_
9	on	on	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	activation	activation	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	promoter	promoter	NN	NN	_	11	nmod	_	_
15	for	for	IN	IN	_	16	case	_	_
16	HLA-DRA	hla-dra	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	the	the	DT	DT	_	22	det	_	_
19	prototype	prototype	NN	NN	_	22	compound	_	_
20	class	class	NN	NN	_	22	compound	_	_
21	II	ii	CD	CD	_	22	nummod	_	_
22	gene	gene	NN	NN	_	16	appos	_	_
23	.	.	.	.	_	3	punct	_	_

1	Oct-1	oct-1	NN	NN	_	10	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	a	a	DT	DT	_	7	det	_	_
4	POU	pou	NN	NN	_	7	compound	_	_
5	domain	domain	NN	NN	_	7	compound	_	_
6	transcription	transcription	NN	NN	_	7	compound	_	_
7	factor	factor	NN	NN	_	1	appos	_	_
8	,	,	,	,	_	10	punct	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	identified	identify	VBN	VBN	_	0	root	_	_
11	as	as	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	repressor	repressor	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	17	case	_	_
15	HLA-DRA	hla-dra	NN	NN	_	17	compound	_	_
16	promoter	promoter	NN	NN	_	17	compound	_	_
17	activity	activity	NN	NN	_	13	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	Rb-defective	rb-defective	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	13	nmod	_	_
22	.	.	.	.	_	10	punct	_	_

1	Rb	rb	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	3	nsubj	_	_
3	led	lead	VBD	VBD	_	0	root	_	_
4	to	to	TO	TO	_	5	case	_	_
5	phosphorylation	phosphorylation	NN	NN	_	3	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	Oct-1	oct-1	NN	NN	_	5	nmod	_	_
8	,	,	,	,	_	3	punct	_	_
9	thus	thus	RB	RB	_	10	advmod	_	_
10	relieving	relieve	VBG	VBG	_	3	xcomp	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	repressive	repressive	JJ	JJ	_	13	amod	_	_
13	effect	effect	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	3	punct	_	_

1	Oct-1	oct-1	NN	NN	_	5	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	5	aux	_	_
3	also	also	RB	RB	_	5	advmod	_	_
4	been	be	VBN	VBN	_	5	auxpass	_	_
5	shown	show	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	repress	repress	VB	VB	_	5	xcomp	_	_
8	interleukin	interleukin	NN	NN	_	11	compound	_	_
9	8	8	CD	CD	_	11	nummod	_	_
10	promoter	promoter	NN	NN	_	11	compound	_	_
11	activity	activity	NN	NN	_	7	dobj	_	_
12	.	.	.	.	_	5	punct	_	_

1	Consistent	consistent	JJ	JJ	_	20	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	reduced	reduce	VBN	VBN	_	4	amod	_	_
4	levels	level	NNS	NNS	_	1	nmod	_	_
5	of	of	IN	IN	_	9	case	_	_
6	Oct-1	oct-1	NN	NN	_	9	compound	_	_
7	DNA	dna	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	4	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	Rb-transformed	rb-transformed	JJ	JJ	_	14	amod	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	lines	line	NNS	NNS	_	9	nmod	_	_
15	,	,	,	,	_	20	punct	_	_
16	interleukin	interleukin	NN	NN	_	18	compound	_	_
17	8	8	CD	CD	_	18	nummod	_	_
18	expression	expression	NN	NN	_	20	nsubj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	higher	higher	JJR	JJR	_	0	root	_	_
21	in	in	IN	IN	_	24	case	_	_
22	these	these	DT	DT	_	24	det	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lines	line	NNS	NNS	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	Protein	protein	NN	NN	_	3	compound	_	_
2	kinase	kinase	NN	NN	_	3	compound	_	_
3	C	c	NN	NN	_	6	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	calcineurin	calcineurin	NN	NN	_	3	conj	_	_
6	synergize	synergize	VBP	VBP	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	activate	activate	VB	VB	_	6	xcomp	_	_
9	IkappaB	ikappab	NN	NN	_	10	compound	_	_
10	kinase	kinase	NN	NN	_	8	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	10	conj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	lymphocytes	lymphocyte	NNS	NNS	_	10	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	13	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	kappaB	kappab	NN	NN	_	3	nmod	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	3	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	a	a	DT	DT	_	13	det	_	_
11	ubiquitous	ubiquitous	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	0	root	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	key	key	JJ	JJ	_	13	acl:relcl	_	_
17	in	in	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	regulation	regulation	NN	NN	_	16	nmod	_	_
20	of	of	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	dep	_	_
22	immune	immune	JJ	JJ	_	23	amod	_	_
23	response	response	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	inflammation	inflammation	NN	NN	_	23	conj	_	_
26	.	.	.	.	_	13	punct	_	_

1	T	t	NN	NN	_	3	compound	_	_
2	cell	cell	NN	NN	_	3	compound	_	_
3	receptor	receptor	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TCR	tcr	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	cross-linking	cross-linking	NN	NN	_	11	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	11	auxpass	_	_
9	in	in	IN	IN	_	10	case	_	_
10	part	part	NN	NN	_	11	nmod	_	_
11	required	require	VBN	VBN	_	0	root	_	_
12	for	for	IN	IN	_	13	case	_	_
13	activation	activation	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	NF-kappaB	nf-kappab	NN	NN	_	13	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	dependent	dependent	JJ	JJ	_	15	acl:relcl	_	_
20	on	on	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	dep	_	_
22	phosphorylation	phosphorylation	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	22	cc	_	_
24	degradation	degradation	NN	NN	_	22	conj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	IkappaBalpha	ikappabalpha	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	11	punct	_	_

1	By	by	IN	IN	_	2	mark	_	_
2	using	use	VBG	VBG	_	11	advcl	_	_
3	Jurkat	jurkat	NN	NN	_	2	dobj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	primary	primary	JJ	JJ	_	8	amod	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	3	conj	_	_
9	,	,	,	,	_	11	punct	_	_
10	we	we	PRP	PRP	_	11	nsubj	_	_
11	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
12	that	that	IN	IN	_	35	mark	_	_
13	the	the	DT	DT	_	15	det	_	_
14	simultaneous	simultaneous	JJ	JJ	_	15	amod	_	_
15	activation	activation	NN	NN	_	35	nsubj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	two	two	CD	CD	_	19	nummod	_	_
18	second	second	JJ	JJ	_	19	amod	_	_
19	messengers	messenger	NNS	NNS	_	15	nmod	_	_
20	of	of	IN	IN	_	24	case	_	_
21	the	the	DT	DT	_	24	det	_	_
22	TCR-initiated	tcr-initiated	JJ	JJ	_	24	amod	_	_
23	signal	signal	NN	NN	_	24	compound	_	_
24	transduction	transduction	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	protein	protein	NN	NN	_	28	compound	_	_
27	kinase	kinase	NN	NN	_	28	compound	_	_
28	C	c	NN	NN	_	19	appos	_	_
29	(	(	-LRB-	-LRB-	_	30	punct	_	_
30	PKC	pkc	NN	NN	_	28	appos	_	_
31	)	)	-RRB-	-RRB-	_	30	punct	_	_
32	and	and	CC	CC	_	28	cc	_	_
33	calcineurin	calcineurin	NN	NN	_	28	conj	_	_
34	,	,	,	,	_	35	punct	_	_
35	results	result	VBZ	VBZ	_	11	ccomp	_	_
36	in	in	IN	IN	_	39	case	_	_
37	the	the	DT	DT	_	39	det	_	_
38	synergistic	synergistic	JJ	JJ	_	39	amod	_	_
39	activation	activation	NN	NN	_	35	nmod	_	_
40	of	of	IN	IN	_	47	case	_	_
41	the	the	DT	DT	_	47	det	_	_
42	IkappaBalpha	ikappabalpha	NN	NN	_	43	compound	_	_
43	kinase	kinase	NN	NN	_	47	compound	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	IKK	ikk	NN	NN	_	43	appos	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	complex	complex	NN	NN	_	39	nmod	_	_
48	but	but	CC	CC	_	47	cc	_	_
49	not	not	RB	RB	_	54	neg	_	_
50	of	of	IN	IN	_	54	case	_	_
51	another	another	DT	DT	_	54	det	_	_
52	putative	putative	JJ	JJ	_	54	amod	_	_
53	IkappaBalpha	ikappabalpha	NN	NN	_	54	compound	_	_
54	kinase	kinase	NN	NN	_	47	conj	_	_
55	,	,	,	,	_	54	punct	_	_
56	p90	p90	NN	NN	_	58	compound	_	_
57	(	(	-LRB-	-LRB-	_	58	punct	_	_
58	rsk	rsk	NN	NN	_	54	appos	_	_
59	)	)	-RRB-	-RRB-	_	58	punct	_	_
60	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	the	the	DT	DT	_	7	dep	_	_
6	IKK	ikk	NN	NN	_	7	compound	_	_
7	complex	complex	NN	NN	_	17	nsubj	_	_
8	,	,	,	,	_	7	punct	_	_
9	but	but	CC	CC	_	7	cc	_	_
10	not	not	RB	RB	_	13	neg	_	_
11	p90	p90	NN	NN	_	13	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	rsk	rsk	NN	NN	_	7	conj	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	,	,	,	,	_	17	punct	_	_
16	is	be	VBZ	VBZ	_	17	cop	_	_
17	responsible	responsible	JJ	JJ	_	3	ccomp	_	_
18	for	for	IN	IN	_	22	case	_	_
19	the	the	DT	DT	_	22	det	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	vivo	vivo	FW	FW	_	20	dep	_	_
22	phosphorylation	phosphorylation	NN	NN	_	17	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IkappaBalpha	ikappabalpha	NN	NN	_	22	nmod	_	_
25	mediated	mediate	VBN	VBN	_	24	acl	_	_
26	by	by	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	co-activation	co-activation	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	PKC	pkc	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	calcineurin	calcineurin	NN	NN	_	30	conj	_	_
33	.	.	.	.	_	3	punct	_	_

1	Each	each	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	messenger	messenger	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	necessary	necessary	JJ	JJ	_	0	root	_	_
6	,	,	,	,	_	5	punct	_	_
7	as	as	IN	IN	_	12	mark	_	_
8	inhibition	inhibition	NN	NN	_	12	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	either	either	DT	DT	_	11	dep	_	_
11	one	one	CD	CD	_	8	nmod	_	_
12	reverses	reverse	VBZ	VBZ	_	5	advcl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activation	activation	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	dep	_	_
17	IKK	ikk	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	IkappaBalpha	ikappabalpha	NN	NN	_	21	compound	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	conj	_	_
22	in	in	FW	FW	_	23	compound	_	_
23	vivo	vivo	FW	FW	_	12	advmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Overexpression	overexpression	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	dominant	dominant	JJ	JJ	_	5	amod	_	_
4	negative	negative	JJ	JJ	_	5	amod	_	_
5	forms	form	NNS	NNS	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	IKKalpha	ikkalpha	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	-beta	-beta	NN	NN	_	7	conj	_	_
10	demonstrates	demonstrate	VBZ	VBZ	_	0	root	_	_
11	that	that	IN	IN	_	16	mark	_	_
12	only	only	JJ	JJ	_	13	advmod	_	_
13	IKKbeta	ikkbeta	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	the	the	DT	DT	_	16	det	_	_
16	target	target	NN	NN	_	10	ccomp	_	_
17	for	for	IN	IN	_	18	case	_	_
18	PKC	pkc	NN	NN	_	16	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	calcineurin	calcineurin	NN	NN	_	18	conj	_	_
21	.	.	.	.	_	10	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	16	mark	_	_
5	within	within	IN	IN	_	10	case	_	_
6	the	the	DT	DT	_	10	det	_	_
7	TCR/CD3	tcr/cd3	NN	NN	_	10	compound	_	_
8	signal	signal	NN	NN	_	10	compound	_	_
9	transduction	transduction	NN	NN	_	10	compound	_	_
10	pathway	pathway	NN	NN	_	16	nmod	_	_
11	both	both	CC	CC	_	12	cc:preconj	_	_
12	PKC	pkc	NN	NN	_	16	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	calcineurin	calcineurin	NN	NN	_	12	conj	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	required	require	VBN	VBN	_	3	ccomp	_	_
17	for	for	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	effective	effective	JJ	JJ	_	20	amod	_	_
20	activation	activation	NN	NN	_	16	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	dep	_	_
23	IKK	ikk	NN	NN	_	24	compound	_	_
24	complex	complex	NN	NN	_	20	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	NF-kappaB	nf-kappab	NN	NN	_	24	conj	_	_
27	in	in	IN	IN	_	29	case	_	_
28	T	t	NN	NN	_	29	compound	_	_
29	lymphocytes	lymphocyte	NNS	NNS	_	24	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	C/EBPbeta	c/ebpbeta	NN	NN	_	5	nsubj	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	GATA-1	gata-1	NN	NN	_	1	conj	_	_
4	synergistically	synergistically	RB	RB	_	5	advmod	_	_
5	regulate	regulate	VBP	VBP	_	0	root	_	_
6	activity	activity	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	eosinophil	eosinophil	NN	NN	_	14	compound	_	_
10	granule	granule	NN	NN	_	14	compound	_	_
11	major	major	JJ	JJ	_	14	amod	_	_
12	basic	basic	JJ	JJ	_	14	amod	_	_
13	protein	protein	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	6	nmod	_	_
15	:	:	:	:	_	5	punct	_	_
16	implication	implication	NN	NN	_	5	dep	_	_
17	for	for	IN	IN	_	19	case	_	_
18	C/EBPbeta	c/ebpbeta	NN	NN	_	19	compound	_	_
19	activity	activity	NN	NN	_	16	nmod	_	_
20	in	in	IN	IN	_	23	case	_	_
21	eosinophil	eosinophil	NN	NN	_	23	compound	_	_
22	gene	gene	NN	NN	_	23	compound	_	_
23	expression	expression	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Eosinophil	eosinophil	NN	NN	_	2	compound	_	_
2	granule	granule	NN	NN	_	10	nsubjpass	_	_
3	major	major	JJ	JJ	_	5	amod	_	_
4	basic	basic	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	2	dep	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	MBP	mbp	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	is	be	VBZ	VBZ	_	10	auxpass	_	_
10	expressed	express	VBN	VBN	_	0	root	_	_
11	exclusively	exclusively	RB	RB	_	10	advmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	eosinophils	eosinophil	NNS	NNS	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	basophils	basophil	NNS	NNS	_	13	conj	_	_
16	in	in	IN	IN	_	18	case	_	_
17	hematopoietic	hematopoietic	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	13	nmod	_	_
19	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
3	previous	previous	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	12	det	_	_
9	major	major	JJ	JJ	_	12	amod	_	_
10	positive	positive	JJ	JJ	_	12	amod	_	_
11	regulatory	regulatory	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	7	dobj	_	_
13	for	for	IN	IN	_	14	case	_	_
14	GATA-1	gata-1	NN	NN	_	12	nmod	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	a	a	DT	DT	_	19	det	_	_
17	negative	negative	JJ	JJ	_	19	amod	_	_
18	regulatory	regulatory	JJ	JJ	_	19	amod	_	_
19	role	role	NN	NN	_	12	conj	_	_
20	for	for	IN	IN	_	21	case	_	_
21	GATA-2	gata-2	NN	NN	_	19	nmod	_	_
22	in	in	IN	IN	_	25	case	_	_
23	MBP	mbp	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	transcription	transcription	NN	NN	_	12	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Further	further	RB	RB	_	2	advmod	_	_
2	analysis	analysis	NN	NN	_	8	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	the	the	DT	DT	_	7	det	_	_
5	MBP	mbp	NN	NN	_	7	compound	_	_
6	promoter	promoter	NN	NN	_	7	compound	_	_
7	region	region	NN	NN	_	2	nmod	_	_
8	identified	identify	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	17	det	_	_
10	C/EBP	c/ebp	NN	NN	_	17	compound	_	_
11	(	(	-LRB-	-LRB-	_	17	punct	_	_
12	CCAAT/enhancer-binding	ccaat/enhancer-binding	JJ	JJ	_	17	amod	_	_
13	protein	protein	NN	NN	_	17	compound	_	_
14	)	)	-RRB-	-RRB-	_	17	punct	_	_
15	consensus	consensus	NN	NN	_	17	compound	_	_
16	binding	binding	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	8	dobj	_	_
18	6	6	CD	CD	_	19	nummod	_	_
19	bp	bp	NN	NN	_	20	nmod:npmod	_	_
20	upstream	upstream	JJ	JJ	_	17	amod	_	_
21	of	of	IN	IN	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	functional	functional	JJ	JJ	_	25	amod	_	_
24	GATA-binding	gata-binding	JJ	JJ	_	25	amod	_	_
25	site	site	NN	NN	_	20	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	MBP	mbp	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	25	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	the	the	DT	DT	_	5	det	_	_
3	cell	cell	NN	NN	_	5	compound	_	_
4	line	line	NN	NN	_	5	compound	_	_
5	HT93A	ht93a	NN	NN	_	31	nmod	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	capable	capable	JJ	JJ	_	5	acl:relcl	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	differentiating	differentiate	VBG	VBG	_	9	advcl	_	_
12	towards	towards	IN	IN	_	15	case	_	_
13	both	both	CC	CC	_	15	cc:preconj	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	eosinophil	eosinophil	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	neutrophil	neutrophil	NN	NN	_	15	conj	_	_
18	lineages	lineage	NNS	NNS	_	15	dep	_	_
19	in	in	IN	IN	_	20	case	_	_
20	response	response	NN	NN	_	11	nmod	_	_
21	to	to	TO	TO	_	23	case	_	_
22	retinoic	retinoic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	20	nmod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	RA	ra	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	31	punct	_	_
28	C/EBPalpha	c/ebpalpha	NN	NN	_	30	compound	_	_
29	mRNA	mrna	NN	NN	_	30	compound	_	_
30	expression	expression	NN	NN	_	31	nsubj	_	_
31	decreased	decrease	VBD	VBD	_	0	root	_	_
32	significantly	significantly	RB	RB	_	31	advmod	_	_
33	concomitant	concomitant	JJ	JJ	_	31	dobj	_	_
34	with	with	IN	IN	_	38	case	_	_
35	eosinophilic	eosinophilic	JJ	JJ	_	38	amod	_	_
36	and	and	CC	CC	_	35	cc	_	_
37	neutrophilic	neutrophilic	JJ	JJ	_	35	conj	_	_
38	differentiation	differentiation	NN	NN	_	33	nmod	_	_
39	,	,	,	,	_	31	punct	_	_
40	whereas	whereas	IN	IN	_	31	dep	_	_
41	C/EBPbeta	c/ebpbeta	NN	NN	_	42	compound	_	_
42	expression	expression	NN	NN	_	45	nsubjpass	_	_
43	was	be	VBD	VBD	_	45	auxpass	_	_
44	markedly	markedly	RB	RB	_	45	advmod	_	_
45	increased	increase	VBN	VBN	_	31	parataxis	_	_
46	.	.	.	.	_	31	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	4	amod	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	VB	VB	_	4	dep	_	_
4	assays	assay	NNS	NNS	_	8	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	EMSAs	emsa	NNS	NNS	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	showed	show	VBD	VBD	_	0	root	_	_
9	that	that	IN	IN	_	14	mark	_	_
10	recombinant	recombinant	JJ	JJ	_	12	amod	_	_
11	C/EBPbeta	c/ebpbeta	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	14	nsubj	_	_
13	could	could	MD	MD	_	14	aux	_	_
14	bind	bind	VB	VB	_	8	ccomp	_	_
15	to	to	TO	TO	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	potential	potential	JJ	JJ	_	19	amod	_	_
18	C/EBP-binding	c/ebp-binding	JJ	JJ	_	19	amod	_	_
19	site	site	NN	NN	_	14	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	bp	bp	NN	NN	_	19	appos	_	_
22	-90	-90	CD	CD	_	21	nummod	_	_
23	to	to	TO	TO	_	21	dep	_	_
24	-82	-82	CD	CD	_	21	nummod	_	_
25	)	)	-RRB-	-RRB-	_	21	punct	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	MBP	mbp	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	19	nmod	_	_
30	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	C/EBPbeta	c/ebpbeta	NN	NN	_	12	nsubj	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GATA-1	gata-1	NN	NN	_	8	conj	_	_
11	can	can	MD	MD	_	12	aux	_	_
12	bind	bind	VB	VB	_	5	ccomp	_	_
13	simultaneously	simultaneously	RB	RB	_	12	advmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	the	the	DT	DT	_	16	dep	_	_
16	C/EBP-	c/ebp-	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	GATA-binding	gata-binding	JJ	JJ	_	19	amod	_	_
19	sites	site	NNS	NNS	_	16	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	the	the	DT	DT	_	23	det	_	_
22	MBP	mbp	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	16	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	determine	determine	VB	VB	_	14	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	functionality	functionality	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	both	both	CC	CC	_	8	cc:preconj	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	C/EBP-	c/ebp-	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	GATA-binding	gata-binding	JJ	JJ	_	11	amod	_	_
11	sites	site	NNS	NNS	_	8	conj	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	analyzed	analyze	VBD	VBD	_	0	root	_	_
15	whether	whether	IN	IN	_	20	mark	_	_
16	C/EBPbeta	c/ebpbeta	NN	NN	_	20	nsubj	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	GATA-1	gata-1	NN	NN	_	16	conj	_	_
19	can	can	MD	MD	_	20	aux	_	_
20	stimulate	stimulate	VB	VB	_	14	ccomp	_	_
21	the	the	DT	DT	_	23	det	_	_
22	MBP	mbp	NN	NN	_	23	compound	_	_
23	promoter	promoter	NN	NN	_	20	dobj	_	_
24	in	in	IN	IN	_	32	case	_	_
25	the	the	DT	DT	_	32	det	_	_
26	C/EBPbeta	c/ebpbeta	NN	NN	_	32	compound	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	GATA-1	gata-1	NN	NN	_	26	conj	_	_
29	negative	negative	JJ	JJ	_	32	amod	_	_
30	Jurkat	jurkat	NN	NN	_	32	compound	_	_
31	T-cell	t-cell	NN	NN	_	32	compound	_	_
32	line	line	NN	NN	_	23	nmod	_	_
33	.	.	.	.	_	14	punct	_	_

1	Cotransfection	cotransfection	NN	NN	_	8	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	C/EBPbeta	c/ebpbeta	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	GATA-1	gata-1	NN	NN	_	3	conj	_	_
6	expression	expression	NN	NN	_	7	compound	_	_
7	vectors	vector	NNS	NNS	_	3	dep	_	_
8	produced	produce	VBD	VBD	_	0	root	_	_
9	a	a	DT	DT	_	11	det	_	_
10	5-fold	5-fold	JJ	JJ	_	11	amod	_	_
11	increase	increase	NN	NN	_	8	dobj	_	_
12	compared	compare	VBN	VBN	_	14	case	_	_
13	with	with	IN	IN	_	14	case	_	_
14	cotransfection	cotransfection	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	C/EBPbeta	c/ebpbeta	NN	NN	_	14	nmod	_	_
18	or	or	CC	CC	_	17	cc	_	_
19	GATA-1	gata-1	NN	NN	_	17	conj	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	vectors	vector	NNS	NNS	_	17	dep	_	_
22	individually	individually	RB	RB	_	14	advmod	_	_
23	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	7	nmod	_	_
3	,	,	,	,	_	7	punct	_	_
4	GST	gst	NN	NN	_	6	compound	_	_
5	pull-down	pull-down	JJ	JJ	_	6	amod	_	_
6	experiments	experiment	NNS	NNS	_	7	nsubj	_	_
7	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	physical	physical	JJ	JJ	_	10	amod	_	_
10	interaction	interaction	NN	NN	_	7	dobj	_	_
11	between	between	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	GATA-1	gata-1	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	C/EBPbeta	c/ebpbeta	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	Expression	expression	NN	NN	_	22	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	FOG	fog	NN	NN	_	1	nmod	_	_
4	(	(	-LRB-	-LRB-	_	6	punct	_	_
5	riend	riend	NN	NN	_	6	compound	_	_
6	ATA	ata	NN	NN	_	3	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	3	punct	_	_
9	which	which	WDT	WDT	_	10	nsubj	_	_
10	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
11	to	to	TO	TO	_	12	case	_	_
12	GATA-1	gata-1	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	acts	act	VBZ	VBZ	_	10	conj	_	_
15	as	as	IN	IN	_	17	case	_	_
16	a	a	DT	DT	_	17	det	_	_
17	cofactor	cofactor	NN	NN	_	14	nmod	_	_
18	for	for	IN	IN	_	20	case	_	_
19	GATA-binding	gata-binding	JJ	JJ	_	20	amod	_	_
20	proteins	protein	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	22	punct	_	_
22	decreased	decrease	VBD	VBD	_	0	root	_	_
23	transactivation	transactivation	NN	NN	_	24	compound	_	_
24	activity	activity	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	GATA-1	gata-1	NN	NN	_	24	nmod	_	_
27	for	for	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	MBP	mbp	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	22	nmod	_	_
31	in	in	IN	IN	_	34	case	_	_
32	a	a	DT	DT	_	34	det	_	_
33	dose-dependent	dose-dependent	JJ	JJ	_	34	amod	_	_
34	manner	manner	NN	NN	_	22	nmod	_	_
35	.	.	.	.	_	22	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	provide	provide	VBP	VBP	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	first	first	JJ	JJ	_	6	amod	_	_
6	evidence	evidence	NN	NN	_	3	dobj	_	_
7	that	that	IN	IN	_	13	mark	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	GATA-1	gata-1	NN	NN	_	13	nsubj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	C/EBPbeta	c/ebpbeta	NN	NN	_	9	conj	_	_
12	synergistically	synergistically	RB	RB	_	13	advmod	_	_
13	transactivate	transactivate	VBP	VBP	_	6	dep	_	_
14	the	the	DT	DT	_	15	det	_	_
15	promoter	promoter	NN	NN	_	13	dobj	_	_
16	of	of	IN	IN	_	21	case	_	_
17	an	a	DT	DT	_	21	det	_	_
18	eosinophil-specific	eosinophil-specific	JJ	JJ	_	21	amod	_	_
19	granule	granule	NN	NN	_	21	compound	_	_
20	protein	protein	NN	NN	_	21	compound	_	_
21	gene	gene	NN	NN	_	15	nmod	_	_
22	and	and	CC	CC	_	13	cc	_	_
23	that	that	IN	IN	_	26	mark	_	_
24	FOG	fog	NN	NN	_	26	nsubj	_	_
25	may	may	MD	MD	_	26	aux	_	_
26	act	act	VB	VB	_	13	conj	_	_
27	as	as	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	negative	negative	JJ	JJ	_	30	amod	_	_
30	cofactor	cofactor	NN	NN	_	26	nmod	_	_
31	for	for	IN	IN	_	34	case	_	_
32	the	the	DT	DT	_	34	det	_	_
33	eosinophil	eosinophil	NN	NN	_	34	compound	_	_
34	lineage	lineage	NN	NN	_	30	nmod	_	_
35	,	,	,	,	_	26	punct	_	_
36	unlike	unlike	IN	IN	_	40	case	_	_
37	its	its	PRP$	PRP$	_	40	nmod:poss	_	_
38	positively	positively	RB	RB	_	39	advmod	_	_
39	regulatory	regulatory	JJ	JJ	_	40	amod	_	_
40	function	function	NN	NN	_	26	nmod	_	_
41	for	for	IN	IN	_	46	case	_	_
42	the	the	DT	DT	_	46	det	_	_
43	erythroid	erythroid	JJ	JJ	_	46	amod	_	_
44	and	and	CC	CC	_	43	cc	_	_
45	megakaryocyte	megakaryocyte	NN	NN	_	43	conj	_	_
46	lineages	lineage	NNS	NNS	_	40	nmod	_	_
47	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	Legionella	legionella	NN	NN	_	5	compound	_	_
3	pneumophila	pneumophila	NN	NN	_	5	compound	_	_
4	rpoS	rpos	NN	NN	_	5	compound	_	_
5	gene	gene	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	required	require	VBN	VBN	_	0	root	_	_
8	for	for	IN	IN	_	9	case	_	_
9	growth	growth	NN	NN	_	7	nmod	_	_
10	within	within	IN	IN	_	12	case	_	_
11	Acanthamoeba	acanthamoeba	NN	NN	_	12	compound	_	_
12	castellanii	castellanii	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	investigate	investigate	VB	VB	_	25	advcl	_	_
3	regulatory	regulatory	JJ	JJ	_	4	amod	_	_
4	networks	network	NNS	NNS	_	2	dobj	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Legionella	legionella	NN	NN	_	7	compound	_	_
7	pneumophila	pneumophila	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	25	punct	_	_
9	the	the	DT	DT	_	10	det	_	_
10	gene	gene	NN	NN	_	25	nsubjpass	_	_
11	encoding	encode	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	homolog	homolog	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	18	case	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Escherichia	escherichia	FW	FW	_	18	compound	_	_
17	coli	coli	FW	FW	_	18	compound	_	_
18	stress	stress	NN	NN	_	13	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	stationary-phase	stationary-phase	NN	NN	_	23	compound	_	_
21	sigma	sigma	NN	NN	_	23	compound	_	_
22	factor	factor	NN	NN	_	23	compound	_	_
23	RpoS	rpos	NN	NN	_	18	conj	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	identified	identify	VBN	VBN	_	0	root	_	_
26	by	by	IN	IN	_	27	case	_	_
27	complementation	complementation	NN	NN	_	25	nmod	_	_
28	of	of	IN	IN	_	33	case	_	_
29	an	a	DT	DT	_	33	det	_	_
30	E.	e.	FW	FW	_	33	compound	_	_
31	coli	coli	FW	FW	_	33	compound	_	_
32	rpoS	rpos	NN	NN	_	33	compound	_	_
33	mutation	mutation	NN	NN	_	27	nmod	_	_
34	.	.	.	.	_	25	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	open	open	JJ	JJ	_	4	amod	_	_
3	reading	reading	NN	NN	_	4	compound	_	_
4	frame	frame	NN	NN	_	18	nsubjpass	_	_
5	that	that	WDT	WDT	_	10	nsubj	_	_
6	is	be	VBZ	VBZ	_	10	cop	_	_
7	approximately	approximately	RB	RB	_	8	advmod	_	_
8	60	60	CD	CD	_	9	nummod	_	_
9	%	%	NN	NN	_	10	nmod:npmod	_	_
10	identical	identical	JJ	JJ	_	4	acl:relcl	_	_
11	to	to	TO	TO	_	16	case	_	_
12	the	the	DT	DT	_	16	det	_	_
13	E.	e.	FW	FW	_	16	compound	_	_
14	coli	coli	FW	FW	_	16	compound	_	_
15	rpoS	rpos	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	10	nmod	_	_
17	was	be	VBD	VBD	_	18	auxpass	_	_
18	identified	identify	VBN	VBN	_	0	root	_	_
19	.	.	.	.	_	18	punct	_	_

1	Western	western	JJ	JJ	_	3	amod	_	_
2	blot	blot	NN	NN	_	3	compound	_	_
3	analysis	analysis	NN	NN	_	4	nsubj	_	_
4	showed	show	VBD	VBD	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	level	level	NN	NN	_	12	nsubj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	L.	l.	FW	FW	_	11	compound	_	_
10	pneumophila	pneumophila	FW	FW	_	11	compound	_	_
11	RpoS	rpos	NN	NN	_	7	nmod	_	_
12	increased	increase	VBD	VBD	_	4	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	stationary	stationary	JJ	JJ	_	15	amod	_	_
15	phase	phase	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	insertion	insertion	NN	NN	_	3	compound	_	_
3	mutation	mutation	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	constructed	construct	VBN	VBN	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	det	_	_
8	rpoS	rpos	NN	NN	_	9	compound	_	_
9	gene	gene	NN	NN	_	5	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	chromosome	chromosome	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	L.	l.	FW	FW	_	15	compound	_	_
15	pneumophila	pneumophila	FW	FW	_	12	nmod	_	_
16	,	,	,	,	_	5	punct	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	ability	ability	NN	NN	_	30	nsubjpass	_	_
20	of	of	IN	IN	_	23	case	_	_
21	this	this	DT	DT	_	23	det	_	_
22	mutant	mutant	JJ	JJ	_	23	amod	_	_
23	strain	strain	NN	NN	_	19	nmod	_	_
24	to	to	TO	TO	_	25	mark	_	_
25	survive	survive	VB	VB	_	19	acl	_	_
26	various	various	JJ	JJ	_	28	amod	_	_
27	stress	stress	NN	NN	_	28	compound	_	_
28	conditions	condition	NNS	NNS	_	25	dobj	_	_
29	was	be	VBD	VBD	_	30	auxpass	_	_
30	assayed	assay	VBN	VBN	_	5	conj	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	compared	compare	VBN	VBN	_	30	conj	_	_
33	with	with	IN	IN	_	34	case	_	_
34	results	result	NNS	NNS	_	32	nmod	_	_
35	for	for	IN	IN	_	38	case	_	_
36	the	the	DT	DT	_	38	det	_	_
37	wild-type	wild-type	JJ	JJ	_	38	amod	_	_
38	strain	strain	NN	NN	_	34	nmod	_	_
39	.	.	.	.	_	5	punct	_	_

1	Both	both	CC	CC	_	3	cc:preconj	_	_
2	the	the	DT	DT	_	3	dep	_	_
3	mutant	mutant	JJ	JJ	_	9	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	wild-type	wild-type	JJ	JJ	_	6	amod	_	_
6	strains	strain	NNS	NNS	_	3	conj	_	_
7	were	be	VBD	VBD	_	9	cop	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	resistant	resistant	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	case	_	_
11	stress	stress	NN	NN	_	9	nmod	_	_
12	when	when	WRB	WRB	_	15	advmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	stationary	stationary	JJ	JJ	_	15	amod	_	_
15	phase	phase	NN	NN	_	9	dep	_	_
16	than	than	IN	IN	_	23	mark	_	_
17	when	when	WRB	WRB	_	23	advmod	_	_
18	in	in	IN	IN	_	23	case	_	_
19	the	the	DT	DT	_	23	det	_	_
20	logarithmic	logarithmic	JJ	JJ	_	23	amod	_	_
21	phase	phase	NN	NN	_	23	compound	_	_
22	of	of	IN	IN	_	23	amod	_	_
23	growth	growth	NN	NN	_	9	advcl	_	_
24	.	.	.	.	_	9	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	finding	finding	NN	NN	_	3	nsubj	_	_
3	indicates	indicate	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	L.	l.	FW	FW	_	7	compound	_	_
6	pneumophila	pneumophila	FW	FW	_	7	compound	_	_
7	RpoS	rpos	NN	NN	_	10	nsubjpass	_	_
8	is	be	VBZ	VBZ	_	10	auxpass	_	_
9	not	not	RB	RB	_	10	neg	_	_
10	required	require	VBN	VBN	_	3	ccomp	_	_
11	for	for	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	stationary-phase-dependent	stationary-phase-dependent	JJ	JJ	_	14	amod	_	_
14	resistance	resistance	NN	NN	_	10	nmod	_	_
15	to	to	TO	TO	_	16	case	_	_
16	stress	stress	NN	NN	_	14	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	6	mark	_	_
2	the	the	DT	DT	_	4	det	_	_
3	mutant	mutant	JJ	JJ	_	4	amod	_	_
4	strain	strain	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	able	able	JJ	JJ	_	17	advcl	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	kill	kill	VB	VB	_	6	xcomp	_	_
9	HL-60-	hl-60-	NN	NN	_	8	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	THP-1-derived	thp-1-derived	JJ	JJ	_	12	amod	_	_
12	macrophages	macrophage	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	17	punct	_	_
14	it	it	PRP	PRP	_	17	nsubj	_	_
15	could	could	MD	MD	_	17	aux	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	replicate	replicate	VB	VB	_	0	root	_	_
18	within	within	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	protozoan	protozoan	NN	NN	_	21	compound	_	_
21	host	host	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	Acanthamoeba	acanthamoeba	NN	NN	_	24	compound	_	_
24	castellanii	castellanii	NN	NN	_	21	appos	_	_
25	.	.	.	.	_	17	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	L.	l.	FW	FW	_	6	compound	_	_
6	pneumophila	pneumophila	FW	FW	_	7	nsubj	_	_
7	possesses	possess	VBZ	VBZ	_	3	ccomp	_	_
8	a	a	DT	DT	_	11	det	_	_
9	growth	growth	NN	NN	_	11	compound	_	_
10	phase-dependent	phase-dependent	JJ	JJ	_	11	amod	_	_
11	resistance	resistance	NN	NN	_	7	dobj	_	_
12	to	to	TO	TO	_	13	case	_	_
13	stress	stress	NN	NN	_	11	nmod	_	_
14	that	that	WDT	WDT	_	16	nsubj	_	_
15	is	be	VBZ	VBZ	_	16	cop	_	_
16	independent	independent	JJ	JJ	_	13	acl:relcl	_	_
17	of	of	IN	IN	_	19	case	_	_
18	RpoS	rpos	NN	NN	_	19	compound	_	_
19	control	control	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	7	cc	_	_
21	that	that	IN	IN	_	24	mark	_	_
22	RpoS	rpos	NN	NN	_	24	nsubj	_	_
23	likely	likely	RB	RB	_	24	advmod	_	_
24	regulates	regulate	VBZ	VBZ	_	7	conj	_	_
25	genes	gene	NNS	NNS	_	24	dobj	_	_
26	that	that	WDT	WDT	_	27	nsubj	_	_
27	enable	enable	VBP	VBP	_	25	acl:relcl	_	_
28	it	it	PRP	PRP	_	27	dobj	_	_
29	to	to	TO	TO	_	30	mark	_	_
30	survive	survive	VB	VB	_	27	xcomp	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	environment	environment	NN	NN	_	30	nmod	_	_
34	within	within	IN	IN	_	35	case	_	_
35	protozoa	protozoa	NN	NN	_	33	nmod	_	_
36	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	14	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	rpoS	rpos	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	L.	l.	NN	NN	_	11	compound	_	_
11	pneumophila	pneumophila	NN	NN	_	6	nmod	_	_
12	is	be	VBZ	VBZ	_	14	cop	_	_
13	very	very	RB	RB	_	14	advmod	_	_
14	different	different	JJ	JJ	_	3	ccomp	_	_
15	from	from	IN	IN	_	20	mark	_	_
16	what	what	WP	WP	_	20	nsubjpass	_	_
17	has	have	VBZ	VBZ	_	20	aux	_	_
18	previously	previously	RB	RB	_	20	advmod	_	_
19	been	be	VBN	VBN	_	20	auxpass	_	_
20	reported	report	VBN	VBN	_	14	advcl	_	_
21	for	for	IN	IN	_	24	case	_	_
22	E.	e.	FW	FW	_	24	compound	_	_
23	coli	coli	FW	FW	_	24	compound	_	_
24	rpoS	rpos	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Thymocyte-thymic	thymocyte-thymic	JJ	JJ	_	4	amod	_	_
2	epithelial	epithelial	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	interaction	interaction	NN	NN	_	5	nsubj	_	_
5	leads	lead	VBZ	VBZ	_	23	dep	_	_
6	to	to	TO	TO	_	8	case	_	_
7	high-level	high-level	JJ	JJ	_	8	amod	_	_
8	replication	replication	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	12	case	_	_
10	human	human	JJ	JJ	_	12	amod	_	_
11	immunodeficiency	immunodeficiency	NN	NN	_	12	compound	_	_
12	virus	virus	NN	NN	_	8	nmod	_	_
13	exclusively	exclusively	RB	RB	_	5	advcl	_	_
14	in	in	IN	IN	_	19	case	_	_
15	mature	mature	JJ	JJ	_	19	amod	_	_
16	CD4(+)	cd4(+)	JJ	JJ	_	19	amod	_	_
17	CD8(-)	cd8(-)	JJ	JJ	_	19	amod	_	_
18	CD3(+)	cd3(+)	JJ	JJ	_	19	amod	_	_
19	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
20	:	:	:	:	_	5	punct	_	_
21	a	a	DT	DT	_	23	det	_	_
22	critical	critical	JJ	JJ	_	23	amod	_	_
23	role	role	NN	NN	_	0	root	_	_
24	for	for	IN	IN	_	27	case	_	_
25	tumor	tumor	NN	NN	_	27	compound	_	_
26	necrosis	necrosis	NN	NN	_	27	compound	_	_
27	factor	factor	NN	NN	_	23	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	interleukin-7	interleukin-7	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	23	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	work	work	NN	NN	_	3	nsubj	_	_
3	aims	aim	VBZ	VBZ	_	0	root	_	_
4	at	at	IN	IN	_	5	mark	_	_
5	identifying	identify	VBG	VBG	_	3	advcl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	thymocyte	thymocyte	NN	NN	_	8	compound	_	_
8	subpopulation	subpopulation	NN	NN	_	5	dobj	_	_
9	able	able	JJ	JJ	_	8	amod	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	support	support	VB	VB	_	9	xcomp	_	_
12	human	human	JJ	JJ	_	18	amod	_	_
13	immunodeficiency	immunodeficiency	NN	NN	_	18	compound	_	_
14	virus	virus	NN	NN	_	18	compound	_	_
15	(	(	-LRB-	-LRB-	_	18	punct	_	_
16	HIV	hiv	NN	NN	_	18	compound	_	_
17	)	)	-RRB-	-RRB-	_	18	punct	_	_
18	replication	replication	NN	NN	_	11	dobj	_	_
19	under	under	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	biological	biological	JJ	JJ	_	22	amod	_	_
22	stimuli	stimulus	NNS	NNS	_	5	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	thymic	thymic	JJ	JJ	_	26	amod	_	_
26	microenvironment	microenvironment	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	5	nmod	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	15	mark	_	_
7	interaction	interaction	NN	NN	_	15	nsubj	_	_
8	with	with	IN	IN	_	11	case	_	_
9	thymic	thymic	JJ	JJ	_	11	amod	_	_
10	epithelial	epithelial	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TEC	tec	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	induces	induce	VBZ	VBZ	_	5	ccomp	_	_
16	a	a	DT	DT	_	18	det	_	_
17	high-level	high-level	JJ	JJ	_	18	amod	_	_
18	replication	replication	NN	NN	_	15	dobj	_	_
19	of	of	IN	IN	_	24	case	_	_
20	the	the	DT	DT	_	24	det	_	_
21	T-tropic	t-tropic	JJ	JJ	_	24	amod	_	_
22	primary	primary	JJ	JJ	_	24	amod	_	_
23	isolate	isolate	JJ	JJ	_	24	amod	_	_
24	HIV-1	hiv-1	NN	NN	_	18	nmod	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	B-LAIp	b-laip	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	exclusively	exclusively	RB	RB	_	15	advcl	_	_
29	in	in	IN	IN	_	35	case	_	_
30	the	the	DT	DT	_	35	det	_	_
31	mature	mature	JJ	JJ	_	35	amod	_	_
32	CD4(+)	cd4(+)	JJ	JJ	_	35	amod	_	_
33	CD8(-)	cd8(-)	JJ	JJ	_	35	amod	_	_
34	CD3(+)	cd3(+)	JJ	JJ	_	35	amod	_	_
35	thymocytes	thymocyte	NNS	NNS	_	28	nmod	_	_
36	.	.	.	.	_	5	punct	_	_

1	Tumor	tumor	NN	NN	_	3	compound	_	_
2	necrosis	necrosis	NN	NN	_	3	compound	_	_
3	factor	factor	NN	NN	_	20	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	TNF	tnf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	and	and	CC	CC	_	3	cc	_	_
8	interleukin-7	interleukin-7	NN	NN	_	3	conj	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	IL-7	il-7	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	3	punct	_	_
13	secreted	secrete	VBN	VBN	_	3	acl	_	_
14	during	during	IN	IN	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	interaction	interaction	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	are	be	VBP	VBP	_	20	cop	_	_
19	critical	critical	JJ	JJ	_	20	amod	_	_
20	cytokines	cytokine	NNS	NNS	_	0	root	_	_
21	for	for	IN	IN	_	26	case	_	_
22	HIV	hiv	NN	NN	_	26	compound	_	_
23	long	long	JJ	JJ	_	26	amod	_	_
24	terminal	terminal	JJ	JJ	_	26	amod	_	_
25	repeat	repeat	NN	NN	_	26	compound	_	_
26	transactivation	transactivation	NN	NN	_	20	nmod	_	_
27	through	through	IN	IN	_	29	case	_	_
28	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	29	amod	_	_
29	activation	activation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	TNF	tnf	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	major	major	JJ	JJ	_	5	amod	_	_
5	inducer	inducer	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	particularly	particularly	RB	RB	_	13	advmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	p50-p65	p50-p65	JJ	JJ	_	13	amod	_	_
13	complex	complex	NN	NN	_	7	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	whereas	whereas	IN	IN	_	5	dep	_	_
16	IL-7	il-7	NN	NN	_	17	nsubj	_	_
17	acts	act	VBZ	VBZ	_	5	parataxis	_	_
18	as	as	IN	IN	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	cofactor	cofactor	NN	NN	_	17	nmod	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	sustaining	sustain	VBG	VBG	_	17	advcl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	expression	expression	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	p75	p75	NN	NN	_	29	compound	_	_
28	TNF	tnf	NN	NN	_	29	compound	_	_
29	receptor	receptor	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	requirement	requirement	NN	NN	_	7	nsubjpass	_	_
3	for	for	IN	IN	_	4	case	_	_
4	TNF	tnf	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	7	auxpass	_	_
6	further	further	RBR	RBR	_	7	advmod	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	observation	observation	NN	NN	_	7	nmod	_	_
11	that	that	IN	IN	_	26	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	inability	inability	NN	NN	_	26	nsubjpass	_	_
14	of	of	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	intermediate	intermediate	JJ	JJ	_	20	amod	_	_
17	CD4(+)	cd4(+)	JJ	JJ	_	20	amod	_	_
18	CD8(-)	cd8(-)	JJ	JJ	_	20	amod	_	_
19	CD3(-)	cd3(-)	JJ	JJ	_	20	amod	_	_
20	thymocytes	thymocyte	NNS	NNS	_	13	nmod	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	replicate	replicate	VB	VB	_	13	acl	_	_
23	the	the	DT	DT	_	24	det	_	_
24	virus	virus	NN	NN	_	22	dobj	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	associated	associate	VBN	VBN	_	10	dep	_	_
27	with	with	IN	IN	_	29	case	_	_
28	a	a	DT	DT	_	29	det	_	_
29	defect	defect	NN	NN	_	26	nmod	_	_
30	in	in	IN	IN	_	32	case	_	_
31	TNF	tnf	NN	NN	_	32	compound	_	_
32	production	production	NN	NN	_	29	nmod	_	_
33	during	during	IN	IN	_	35	case	_	_
34	their	they	PRP$	PRP$	_	35	nmod:poss	_	_
35	interaction	interaction	NN	NN	_	29	nmod	_	_
36	with	with	IN	IN	_	37	case	_	_
37	TEC	tec	NN	NN	_	35	nmod	_	_
38	and	and	CC	CC	_	7	cc	_	_
39	correlates	correlate	VBZ	VBZ	_	7	conj	_	_
40	with	with	IN	IN	_	42	case	_	_
41	the	the	DT	DT	_	42	det	_	_
42	absence	absence	NN	NN	_	39	nmod	_	_
43	of	of	IN	IN	_	46	case	_	_
44	nuclear	nuclear	JJ	JJ	_	46	amod	_	_
45	NF-kappaB	nf-kappab	NN	NN	_	46	compound	_	_
46	activity	activity	NN	NN	_	42	nmod	_	_
47	in	in	IN	IN	_	51	case	_	_
48	these	these	DT	DT	_	51	det	_	_
49	freshly	freshly	RB	RB	_	51	advmod	_	_
50	isolated	isolate	VBN	VBN	_	51	amod	_	_
51	thymocytes	thymocyte	NNS	NNS	_	42	nmod	_	_
52	.	.	.	.	_	7	punct	_	_

1	Addition	addition	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	exogenous	exogenous	JJ	JJ	_	4	amod	_	_
4	TNF	tnf	NN	NN	_	1	nmod	_	_
5	to	to	TO	TO	_	9	case	_	_
6	the	the	DT	DT	_	9	det	_	_
7	intermediate	intermediate	JJ	JJ	_	9	amod	_	_
8	thymocyte	thymocyte	NN	NN	_	9	compound	_	_
9	cultures	culture	NNS	NNS	_	1	nmod	_	_
10	induces	induce	VBZ	VBZ	_	0	root	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	12	compound	_	_
12	activity	activity	NN	NN	_	10	dobj	_	_
13	and	and	CC	CC	_	10	cc	_	_
14	is	be	VBZ	VBZ	_	15	cop	_	_
15	sufficient	sufficient	JJ	JJ	_	10	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	promote	promote	VB	VB	_	15	xcomp	_	_
18	HIV	hiv	NN	NN	_	19	compound	_	_
19	replication	replication	NN	NN	_	17	dobj	_	_
20	in	in	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	cocultures	coculture	NNS	NNS	_	17	nmod	_	_
23	with	with	IN	IN	_	24	case	_	_
24	TEC	tec	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	10	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	other	other	JJ	JJ	_	4	amod	_	_
3	major	major	JJ	JJ	_	4	amod	_	_
4	subpopulation	subpopulation	NN	NN	_	31	nsubj	_	_
5	expressing	express	VBG	VBG	_	4	acl	_	_
6	the	the	DT	DT	_	8	det	_	_
7	CD4	cd4	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	5	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	namely	namely	RB	RB	_	8	advmod	_	_
11	,	,	,	,	_	8	punct	_	_
12	the	the	DT	DT	_	20	det	_	_
13	double-positive	double-positive	JJ	JJ	_	20	amod	_	_
14	(	(	-LRB-	-LRB-	_	20	punct	_	_
15	DP	dp	NN	NN	_	20	compound	_	_
16	)	)	-RRB-	-RRB-	_	20	punct	_	_
17	CD4(+)	cd4(+)	JJ	JJ	_	20	amod	_	_
18	CD8(+)	cd8(+)	JJ	JJ	_	20	amod	_	_
19	CD3(+/-)	cd3(+/-)	JJ	JJ	_	20	amod	_	_
20	thymocytes	thymocyte	NNS	NNS	_	8	appos	_	_
21	,	,	,	,	_	31	punct	_	_
22	despite	despite	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	entry	entry	NN	NN	_	31	nmod	_	_
25	of	of	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	virus	virus	NN	NN	_	24	nmod	_	_
28	,	,	,	,	_	31	punct	_	_
29	do	do	VBP	VBP	_	31	aux	_	_
30	not	not	RB	RB	_	31	neg	_	_
31	produce	produce	VB	VB	_	0	root	_	_
32	a	a	DT	DT	_	34	det	_	_
33	significant	significant	JJ	JJ	_	34	amod	_	_
34	level	level	NN	NN	_	31	dobj	_	_
35	of	of	IN	IN	_	36	case	_	_
36	virus	virus	NN	NN	_	34	nmod	_	_
37	,	,	,	,	_	31	punct	_	_
38	presumably	presumably	RB	RB	_	42	advmod	_	_
39	because	because	IN	IN	_	42	mark	_	_
40	they	they	PRP	PRP	_	42	nsubj	_	_
41	are	be	VBP	VBP	_	42	cop	_	_
42	unresponsive	unresponsive	JJ	JJ	_	31	advcl	_	_
43	to	to	TO	TO	_	44	case	_	_
44	TNF	tnf	NN	NN	_	42	nmod	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	IL-7	il-7	NN	NN	_	44	conj	_	_
47	.	.	.	.	_	31	punct	_	_

1	Together	together	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	these	these	DT	DT	_	4	det	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	29	mark	_	_
7	in	in	FW	FW	_	8	compound	_	_
8	vivo	vivo	FW	FW	_	29	advmod	_	_
9	,	,	,	,	_	29	punct	_	_
10	despite	despite	IN	IN	_	13	case	_	_
11	an	a	DT	DT	_	13	det	_	_
12	efficient	efficient	JJ	JJ	_	13	amod	_	_
13	entry	entry	NN	NN	_	29	dep	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	virus	virus	NN	NN	_	13	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	all	all	PDT	PDT	_	21	det:predet	_	_
19	the	the	DT	DT	_	21	det	_	_
20	CD4(+)	cd4(+)	JJ	JJ	_	21	amod	_	_
21	subpopulations	subpopulation	NNS	NNS	_	13	nmod	_	_
22	,	,	,	,	_	29	punct	_	_
23	a	a	DT	DT	_	26	det	_	_
24	high	high	JJ	JJ	_	26	amod	_	_
25	viral	viral	JJ	JJ	_	26	amod	_	_
26	load	load	NN	NN	_	29	dep	_	_
27	may	may	MD	MD	_	29	aux	_	_
28	be	be	VB	VB	_	29	auxpass	_	_
29	generated	generate	VBN	VBN	_	5	dep	_	_
30	exclusively	exclusively	RB	RB	_	29	advmod	_	_
31	within	within	IN	IN	_	39	case	_	_
32	the	the	DT	DT	_	39	det	_	_
33	mature	mature	JJ	JJ	_	39	amod	_	_
34	CD4(+)	cd4(+)	JJ	JJ	_	39	amod	_	_
35	CD8(-)	cd8(-)	JJ	JJ	_	39	amod	_	_
36	CD3(+)	cd3(+)	JJ	JJ	_	39	amod	_	_
37	subset	subset	NN	NN	_	39	compound	_	_
38	of	of	IN	IN	_	39	amod	_	_
39	thymocytes	thymocyte	NNS	NNS	_	29	nmod	_	_
40	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	15	advmod	_	_
2	,	,	,	,	_	15	punct	_	_
3	under	under	IN	IN	_	4	case	_	_
4	conditions	condition	NNS	NNS	_	15	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	response	response	NN	NN	_	4	nmod	_	_
8	after	after	IN	IN	_	9	case	_	_
9	infection	infection	NN	NN	_	4	nmod	_	_
10	,	,	,	,	_	15	punct	_	_
11	TNF	tnf	NN	NN	_	15	nsubj	_	_
12	might	might	MD	MD	_	15	aux	_	_
13	also	also	RB	RB	_	15	advmod	_	_
14	be	be	VB	VB	_	15	cop	_	_
15	present	present	JJ	JJ	_	0	root	_	_
16	in	in	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	intermediate	intermediate	JJ	JJ	_	20	amod	_	_
19	thymocyte	thymocyte	NN	NN	_	20	compound	_	_
20	compartment	compartment	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	leading	lead	VBG	VBG	_	15	xcomp	_	_
23	to	to	TO	TO	_	26	case	_	_
24	efficient	efficient	JJ	JJ	_	26	amod	_	_
25	HIV	hiv	NN	NN	_	26	compound	_	_
26	replication	replication	NN	NN	_	22	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	these	these	DT	DT	_	29	det	_	_
29	cells	cell	NNS	NNS	_	26	nmod	_	_
30	.	.	.	.	_	15	punct	_	_

1	Cutting	cutting	JJ	JJ	_	2	amod	_	_
2	edge	edge	NN	NN	_	0	root	_	_
3	:	:	:	:	_	2	punct	_	_
4	TCR	tcr	NN	NN	_	5	compound	_	_
5	stimulation	stimulation	NN	NN	_	11	nsubj	_	_
6	by	by	IN	IN	_	7	case	_	_
7	antibody	antibody	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	bacterial	bacterial	JJ	JJ	_	10	amod	_	_
10	superantigen	superantigen	NN	NN	_	7	conj	_	_
11	induces	induce	VBZ	VBZ	_	2	dep	_	_
12	Stat3	stat3	NN	NN	_	13	compound	_	_
13	activation	activation	NN	NN	_	11	dobj	_	_
14	in	in	IN	IN	_	17	case	_	_
15	human	human	JJ	JJ	_	17	amod	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	11	nmod	_	_
18	.	.	.	.	_	2	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	7	mark	_	_
5	TCR/CD3	tcr/cd3	JJ	JJ	_	6	amod	_	_
6	stimulation	stimulation	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
8	activation	activation	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	Stat5	stat5	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	murine	murine	JJ	JJ	_	14	amod	_	_
13	T	t	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	7	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	show	show	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	16	mark	_	_
6	CD3	cd3	NN	NN	_	7	compound	_	_
7	ligation	ligation	NN	NN	_	16	nsubj	_	_
8	by	by	IN	IN	_	9	case	_	_
9	mAb	mab	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	Staphylococcal	staphylococcal	JJ	JJ	_	12	amod	_	_
12	enterotoxin	enterotoxin	NN	NN	_	9	conj	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	SE	se	NN	NN	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	induce	induce	VBP	VBP	_	4	ccomp	_	_
17	a	a	DT	DT	_	24	dep	_	_
18	rapid	rapid	JJ	JJ	_	24	amod	_	_
19	,	,	,	,	_	18	punct	_	_
20	gradually	gradually	RB	RB	_	21	advmod	_	_
21	accumulating	accumulate	VBG	VBG	_	18	dep	_	_
22	,	,	,	,	_	18	punct	_	_
23	long-lasting	long-lasting	JJ	JJ	_	18	dep	_	_
24	tyrosine	tyrosine	NN	NN	_	16	dobj	_	_
25	,	,	,	,	_	24	punct	_	_
26	and	and	CC	CC	_	24	cc	_	_
27	serine	serine	NN	NN	_	24	conj	_	_
28	phosphorylation	phosphorylation	NN	NN	_	24	dep	_	_
29	of	of	IN	IN	_	30	case	_	_
30	Stat3	stat3	NN	NN	_	24	nmod	_	_
31	(	(	-LRB-	-LRB-	_	34	punct	_	_
32	but	but	CC	CC	_	34	cc	_	_
33	not	not	RB	RB	_	34	dep	_	_
34	Stat5	stat5	NN	NN	_	30	appos	_	_
35	)	)	-RRB-	-RRB-	_	34	punct	_	_
36	in	in	IN	IN	_	42	case	_	_
37	allogen-specific	allogen-specific	JJ	JJ	_	42	amod	_	_
38	human	human	JJ	JJ	_	42	amod	_	_
39	CD4+	cd4+	JJ	JJ	_	42	amod	_	_
40	T	t	NN	NN	_	42	compound	_	_
41	cell	cell	NN	NN	_	42	compound	_	_
42	lines	line	NNS	NNS	_	16	nmod	_	_
43	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	IL-2	il-2	NN	NN	_	5	nsubj	_	_
5	induces	induce	VBZ	VBZ	_	0	root	_	_
6	a	a	DT	DT	_	10	dep	_	_
7	rapid	rapid	JJ	JJ	_	10	amod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	transient	transient	JJ	JJ	_	7	conj	_	_
10	tyrosine	tyrosine	NN	NN	_	5	dobj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	serine	serine	NN	NN	_	10	conj	_	_
13	phosphorylation	phosphorylation	NN	NN	_	10	dep	_	_
14	of	of	IN	IN	_	15	case	_	_
15	Stat3	stat3	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Compared	compare	VBN	VBN	_	3	case	_	_
2	with	with	IN	IN	_	3	case	_	_
3	IL-2	il-2	NN	NN	_	7	advcl	_	_
4	,	,	,	,	_	7	punct	_	_
5	CD3	cd3	NN	NN	_	6	compound	_	_
6	ligation	ligation	NN	NN	_	7	nsubj	_	_
7	induces	induce	VBZ	VBZ	_	0	root	_	_
8	a	a	DT	DT	_	10	det	_	_
9	delayed	delay	VBN	VBN	_	10	amod	_	_
10	Stat3	stat3	NN	NN	_	7	dobj	_	_
11	binding	bind	VBG	VBG	_	10	amod	_	_
12	to	to	TO	TO	_	14	case	_	_
13	oligonucleotide	oligonucleotide	NN	NN	_	14	compound	_	_
14	probes	probe	NNS	NNS	_	10	nmod	_	_
15	from	from	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	dep	_	_
17	ICAM-1	icam-1	NN	NN	_	7	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IL-2R	il-2r	NN	NN	_	21	compound	_	_
20	alpha	alpha	NN	NN	_	21	compound	_	_
21	promoter	promoter	NN	NN	_	17	conj	_	_
22	.	.	.	.	_	7	punct	_	_

1	CD3-mediated	cd3-mediated	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	8	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	Stat3	stat3	NN	NN	_	2	nmod	_	_
5	is	be	VBZ	VBZ	_	8	auxpass	_	_
6	almost	almost	RB	RB	_	7	advmod	_	_
7	completely	completely	RB	RB	_	8	advmod	_	_
8	inhibited	inhibit	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	13	case	_	_
10	a	a	DT	DT	_	13	det	_	_
11	Src	src	NN	NN	_	13	compound	_	_
12	kinase	kinase	NN	NN	_	13	compound	_	_
13	inhibitor	inhibitor	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	PP1	pp1	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	8	punct	_	_
18	whereas	whereas	IN	IN	_	8	dep	_	_
19	IL-2-induced	il-2-induced	JJ	JJ	_	21	amod	_	_
20	Stat3	stat3	NN	NN	_	21	compound	_	_
21	activation	activation	NN	NN	_	23	nsubj	_	_
22	is	be	VBZ	VBZ	_	23	cop	_	_
23	unaffected	unaffected	JJ	JJ	_	8	parataxis	_	_
24	.	.	.	.	_	8	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	show	show	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	CD3	cd3	NN	NN	_	8	compound	_	_
8	ligation	ligation	NN	NN	_	13	nsubj	_	_
9	by	by	IN	IN	_	10	case	_	_
10	mAb	mab	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	SE	se	NN	NN	_	10	conj	_	_
13	triggers	trigger	VBZ	VBZ	_	5	ccomp	_	_
14	a	a	DT	DT	_	18	dep	_	_
15	rapid	rapid	JJ	JJ	_	18	amod	_	_
16	,	,	,	,	_	15	punct	_	_
17	PP1-sensitive	pp1-sensitive	JJ	JJ	_	15	dep	_	_
18	tyrosine	tyrosine	NN	NN	_	13	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	serine	serine	NN	NN	_	18	conj	_	_
21	phosphorylation	phosphorylation	NN	NN	_	18	dep	_	_
22	of	of	IN	IN	_	23	case	_	_
23	Stat3	stat3	NN	NN	_	18	nmod	_	_
24	in	in	IN	IN	_	28	case	_	_
25	human	human	JJ	JJ	_	28	amod	_	_
26	CD4+	cd4+	JJ	JJ	_	28	amod	_	_
27	T	t	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	13	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	provide	provide	VBP	VBP	_	0	root	_	_
5	evidence	evidence	NN	NN	_	4	dobj	_	_
6	that	that	IN	IN	_	10	mark	_	_
7	TCR/CD3	tcr/cd3	JJ	JJ	_	10	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-2	il-2	NN	NN	_	7	conj	_	_
10	induce	induce	VBP	VBP	_	5	dep	_	_
11	Stat3	stat3	NN	NN	_	12	compound	_	_
12	activation	activation	NN	NN	_	10	dobj	_	_
13	via	via	IN	IN	_	16	case	_	_
14	distinct	distinct	JJ	JJ	_	16	amod	_	_
15	signaling	signaling	NN	NN	_	16	compound	_	_
16	pathways	pathway	NNS	NNS	_	10	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	IL-2-independent	il-2-independent	JJ	JJ	_	2	amod	_	_
2	activation	activation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	proliferation	proliferation	NN	NN	_	2	conj	_	_
5	in	in	IN	IN	_	8	case	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	induced	induce	VBN	VBN	_	2	acl	_	_
10	by	by	IN	IN	_	11	case	_	_
11	CD28	cd28	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	2	punct	_	_

1	Although	although	IN	IN	_	12	mark	_	_
2	the	the	DT	DT	_	3	det	_	_
3	role	role	NN	NN	_	12	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	CD28	cd28	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	9	case	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	costimulation	costimulation	NN	NN	_	3	nmod	_	_
10	is	be	VBZ	VBZ	_	12	auxpass	_	_
11	firmly	firmly	RB	RB	_	12	advmod	_	_
12	established	establish	VBN	VBN	_	25	advcl	_	_
13	,	,	,	,	_	25	punct	_	_
14	the	the	DT	DT	_	15	det	_	_
15	mechanisms	mechanism	NNS	NNS	_	25	nsubj	_	_
16	by	by	IN	IN	_	17	case	_	_
17	which	which	WDT	WDT	_	19	nmod	_	_
18	it	it	PRP	PRP	_	19	nsubj	_	_
19	exerts	exert	VBZ	VBZ	_	15	acl:relcl	_	_
20	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
21	costimulatory	costimulatory	JJ	JJ	_	22	amod	_	_
22	actions	action	NNS	NNS	_	19	dobj	_	_
23	are	be	VBP	VBP	_	25	cop	_	_
24	less	less	RBR	RBR	_	25	advmod	_	_
25	clear	clear	JJ	JJ	_	0	root	_	_
26	.	.	.	.	_	25	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	many	many	JJ	JJ	_	3	amod	_	_
3	circumstances	circumstance	NNS	NNS	_	6	nmod	_	_
4	it	it	PRP	PRP	_	6	nsubj	_	_
5	is	be	VBZ	VBZ	_	6	cop	_	_
6	difficult	difficult	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	distinguish	distinguish	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	effects	effect	NNS	NNS	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	CD28	cd28	NN	NN	_	10	nmod	_	_
13	from	from	IN	IN	_	15	case	_	_
14	subsequent	subsequent	JJ	JJ	_	15	amod	_	_
15	actions	action	NNS	NNS	_	8	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	cytokines	cytokine	NNS	NNS	_	15	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	such	such	JJ	JJ	_	21	case	_	_
20	as	as	IN	IN	_	21	case	_	_
21	IL-2	il-2	NN	NN	_	17	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	on	on	IN	IN	_	26	case	_	_
24	T	t	NN	NN	_	26	compound	_	_
25	cell	cell	NN	NN	_	26	compound	_	_
26	proliferation	proliferation	NN	NN	_	8	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	report	report	VBP	VBP	_	0	root	_	_
5	a	a	DT	DT	_	6	det	_	_
6	model	model	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	CD28	cd28	NN	NN	_	9	compound	_	_
9	costimulation	costimulation	NN	NN	_	6	nmod	_	_
10	using	use	VBG	VBG	_	9	acl	_	_
11	PMA	pma	NN	NN	_	10	dobj	_	_
12	plus	plus	CC	CC	_	11	cc	_	_
13	the	the	DT	DT	_	16	det	_	_
14	natural	natural	JJ	JJ	_	16	amod	_	_
15	ligand	ligand	NN	NN	_	16	compound	_	_
16	CD80	cd80	NN	NN	_	11	conj	_	_
17	that	that	WDT	WDT	_	18	nsubj	_	_
18	resulted	result	VBD	VBD	_	16	acl:relcl	_	_
19	in	in	IN	IN	_	22	case	_	_
20	very	very	RB	RB	_	22	advmod	_	_
21	limited	limited	JJ	JJ	_	22	amod	_	_
22	stimulation	stimulation	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IL-2	il-2	NN	NN	_	22	nmod	_	_
25	,	,	,	,	_	4	punct	_	_
26	as	as	IN	IN	_	27	mark	_	_
27	evidenced	evidence	VBN	VBN	_	4	advcl	_	_
28	by	by	IN	IN	_	31	case	_	_
29	both	both	CC	CC	_	31	cc:preconj	_	_
30	cytokine	cytokine	NN	NN	_	31	compound	_	_
31	production	production	NN	NN	_	27	nmod	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	IL-2	il-2	NN	NN	_	35	compound	_	_
34	promoter	promoter	NN	NN	_	35	compound	_	_
35	stimulation	stimulation	NN	NN	_	31	conj	_	_
36	.	.	.	.	_	4	punct	_	_

1	Promoter	promoter	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	revealed	reveal	VBD	VBD	_	0	root	_	_
4	CD28-dependent	cd28-dependent	JJ	JJ	_	5	amod	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	on	on	IN	IN	_	8	case	_	_
7	both	both	CC	CC	_	8	cc:preconj	_	_
8	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	AP-1	ap-1	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	but	but	CC	CC	_	8	cc	_	_
13	not	not	RB	RB	_	15	neg	_	_
14	on	on	IN	IN	_	15	case	_	_
15	NF-AT	nf-at	NN	NN	_	8	conj	_	_
16	or	or	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	20	det	_	_
18	intact	intact	JJ	JJ	_	20	amod	_	_
19	IL-2	il-2	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	15	conj	_	_
21	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	T	t	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	proliferation	proliferation	NN	NN	_	9	nsubj	_	_
7	was	be	VBD	VBD	_	9	cop	_	_
8	completely	completely	RB	RB	_	9	advmod	_	_
9	resistant	resistant	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	actions	action	NNS	NNS	_	9	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	immunosuppressant	immunosuppressant	JJ	JJ	_	17	amod	_	_
16	cyclosporin	cyclosporin	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	CsA	csa	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	9	punct	_	_

1	Moreover	moreover	RB	RB	_	6	advmod	_	_
2	T	t	NN	NN	_	4	compound	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	proliferation	proliferation	NN	NN	_	6	nsubj	_	_
5	was	be	VBD	VBD	_	6	cop	_	_
6	unaffected	unaffected	JJ	JJ	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	addition	addition	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	11	mark	_	_
11	blocking	block	VBG	VBG	_	9	acl	_	_
12	Abs	ab	NNS	NNS	_	11	dobj	_	_
13	to	to	TO	TO	_	15	case	_	_
14	both	both	CC	CC	_	15	cc:preconj	_	_
15	IL-2	il-2	NN	NN	_	9	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	the	the	DT	DT	_	19	det	_	_
18	IL-2	il-2	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	15	conj	_	_
20	,	,	,	,	_	6	punct	_	_
21	demonstrating	demonstrate	VBG	VBG	_	6	dep	_	_
22	that	that	IN	IN	_	30	mark	_	_
23	this	this	DT	DT	_	24	det	_	_
24	form	form	NN	NN	_	30	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	costimulation	costimulation	NN	NN	_	24	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	CD28	cd28	NN	NN	_	26	nmod	_	_
29	was	be	VBD	VBD	_	30	cop	_	_
30	independent	independent	JJ	JJ	_	21	ccomp	_	_
31	of	of	IN	IN	_	32	case	_	_
32	IL-2	il-2	NN	NN	_	30	nmod	_	_
33	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	investigated	investigate	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effects	effect	NNS	NNS	_	3	dobj	_	_
6	of	of	IN	IN	_	7	mark	_	_
7	stimulating	stimulate	VBG	VBG	_	5	acl	_	_
8	T	t	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	blasts	blast	NNS	NNS	_	7	dobj	_	_
11	with	with	IN	IN	_	12	case	_	_
12	CD80	cd80	NN	NN	_	7	nmod	_	_
13	alone	alone	RB	RB	_	12	advmod	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	found	find	VBD	VBD	_	3	conj	_	_
16	that	that	IN	IN	_	18	mark	_	_
17	there	there	EX	EX	_	18	expl	_	_
18	was	be	VBD	VBD	_	15	ccomp	_	_
19	a	a	DT	DT	_	21	det	_	_
20	limited	limited	JJ	JJ	_	21	amod	_	_
21	requirement	requirement	NN	NN	_	18	nsubj	_	_
22	for	for	IN	IN	_	23	case	_	_
23	IL-2	il-2	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	this	this	DT	DT	_	26	det	_	_
26	system	system	NN	NN	_	18	nmod	_	_
27	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	7	mark	_	_
4	CD28	cd28	NN	NN	_	5	compound	_	_
5	costimulation	costimulation	NN	NN	_	7	nsubj	_	_
6	can	can	MD	MD	_	7	aux	_	_
7	cause	cause	VB	VB	_	2	ccomp	_	_
8	substantial	substantial	JJ	JJ	_	11	amod	_	_
9	T	t	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	proliferation	proliferation	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	absence	absence	NN	NN	_	7	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IL-2	il-2	NN	NN	_	14	nmod	_	_
17	,	,	,	,	_	16	punct	_	_
18	which	which	WDT	WDT	_	20	nsubjpass	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	driven	drive	VBN	VBN	_	16	acl:relcl	_	_
21	by	by	IN	IN	_	24	case	_	_
22	a	a	DT	DT	_	24	det	_	_
23	soluble	soluble	JJ	JJ	_	24	amod	_	_
24	factor	factor	NN	NN	_	20	nmod	_	_
25	independent	independent	JJ	JJ	_	24	amod	_	_
26	of	of	IN	IN	_	28	case	_	_
27	NF-AT	nf-at	NN	NN	_	28	compound	_	_
28	transactivation	transactivation	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Suppression	suppression	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	TNFalpha-mediated	tnfalpha-mediated	JJ	JJ	_	5	amod	_	_
4	NFkappaB	nfkappab	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	myricetin	myricetin	NN	NN	_	1	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	other	other	JJ	JJ	_	10	amod	_	_
10	flavonoids	flavonoid	NNS	NNS	_	7	conj	_	_
11	through	through	IN	IN	_	12	mark	_	_
12	downregulating	downregulate	VBG	VBG	_	1	acl	_	_
13	the	the	DT	DT	_	14	det	_	_
14	activity	activity	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	IKK	ikk	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	ECV304	ecv304	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	1	punct	_	_

1	Flavonoids	flavonoid	NNS	NNS	_	4	nsubj	_	_
2	are	be	VBP	VBP	_	4	cop	_	_
3	a	a	DT	DT	_	4	det	_	_
4	group	group	NN	NN	_	0	root	_	_
5	of	of	IN	IN	_	8	case	_	_
6	naturally-occurring	naturally-occurring	JJ	JJ	_	8	amod	_	_
7	phenolic	phenolic	JJ	JJ	_	8	amod	_	_
8	compounds	compound	NNS	NNS	_	4	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	plant	plant	NN	NN	_	12	compound	_	_
12	kingdom	kingdom	NN	NN	_	4	nmod	_	_
13	,	,	,	,	_	4	punct	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	many	many	JJ	JJ	_	16	amod	_	_
16	flavonoids	flavonoid	NNS	NNS	_	18	nsubjpass	_	_
17	are	be	VBP	VBP	_	18	auxpass	_	_
18	found	find	VBN	VBN	_	4	conj	_	_
19	with	with	IN	IN	_	22	case	_	_
20	vascular	vascular	JJ	JJ	_	22	amod	_	_
21	protective	protective	JJ	JJ	_	22	amod	_	_
22	properties	property	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Nevertheless	nevertheless	RB	RB	_	13	advmod	_	_
2	how	how	WRB	WRB	_	7	advmod	_	_
3	the	the	DT	DT	_	5	det	_	_
4	protective	protective	JJ	JJ	_	5	amod	_	_
5	response	response	NN	NN	_	7	nsubjpass	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	exerted	exert	VBN	VBN	_	13	csubjpass	_	_
8	by	by	IN	IN	_	9	case	_	_
9	flavonoids	flavonoid	NNS	NNS	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	13	auxpass	_	_
11	not	not	RB	RB	_	13	neg	_	_
12	well	well	RB	RB	_	13	advmod	_	_
13	characterized	characterize	VBN	VBN	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	view	view	NN	NN	_	27	nmod	_	_
3	of	of	IN	IN	_	11	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	factor-kappaB	factor-kappab	NN	NN	_	11	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	NFkappaB	nfkappab	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	play	play	VB	VB	_	2	acl	_	_
12	a	a	DT	DT	_	14	det	_	_
13	central	central	JJ	JJ	_	14	amod	_	_
14	role	role	NN	NN	_	11	dobj	_	_
15	in	in	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	initiation	initiation	NN	NN	_	11	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	atherosclerosis	atherosclerosis	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	27	punct	_	_
21	prevention	prevention	NN	NN	_	27	nsubj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	the	the	DT	DT	_	24	det	_	_
24	activation	activation	NN	NN	_	21	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	NFkappaB	nfkappab	NN	NN	_	24	nmod	_	_
27	represents	represent	VBZ	VBZ	_	0	root	_	_
28	an	a	DT	DT	_	30	det	_	_
29	important	important	JJ	JJ	_	30	amod	_	_
30	role	role	NN	NN	_	27	dobj	_	_
31	in	in	IN	IN	_	32	mark	_	_
32	protecting	protect	VBG	VBG	_	27	advcl	_	_
33	vascular	vascular	JJ	JJ	_	34	amod	_	_
34	injury	injury	NN	NN	_	32	dobj	_	_
35	.	.	.	.	_	27	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	27	nmod	_	_
4	,	,	,	,	_	27	punct	_	_
5	the	the	DT	DT	_	6	det	_	_
6	effects	effect	NNS	NNS	_	27	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	flavonoids	flavonoid	NNS	NNS	_	6	nmod	_	_
9	on	on	IN	IN	_	14	case	_	_
10	NFkappaB/inhibitor-kappaB	nfkappab/inhibitor-kappab	NN	NN	_	14	compound	_	_
11	(	(	-LRB-	-LRB-	_	14	punct	_	_
12	IkappaB	ikappab	NN	NN	_	14	compound	_	_
13	)	)	-RRB-	-RRB-	_	14	punct	_	_
14	system	system	NN	NN	_	6	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	ECV304	ecv304	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	activated	activate	VBN	VBN	_	17	acl	_	_
19	with	with	IN	IN	_	22	case	_	_
20	tumor	tumor	NN	NN	_	22	compound	_	_
21	necrosis	necrosis	NN	NN	_	22	compound	_	_
22	factor-alpha	factor-alpha	NN	NN	_	18	nmod	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	TNFalpha	tnfalpha	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	were	be	VBD	VBD	_	27	auxpass	_	_
27	examined	examine	VBN	VBN	_	0	root	_	_
28	.	.	.	.	_	27	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	investigated	investigate	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	inhibitory	inhibitory	JJ	JJ	_	5	amod	_	_
5	action	action	NN	NN	_	2	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	six	six	CD	CD	_	8	nummod	_	_
8	flavonoids	flavonoid	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	15	case	_	_
10	IkappaB	ikappab	NN	NN	_	11	compound	_	_
11	kinase	kinase	NN	NN	_	15	compound	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	IKK	ikk	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	activity	activity	NN	NN	_	5	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	an	a	DT	DT	_	18	det	_	_
18	enzyme	enzyme	NN	NN	_	15	appos	_	_
19	recently	recently	RB	RB	_	20	advmod	_	_
20	found	find	VBN	VBN	_	18	acl	_	_
21	to	to	TO	TO	_	22	mark	_	_
22	phosphorylate	phosphorylate	VB	VB	_	20	xcomp	_	_
23	critical	critical	JJ	JJ	_	25	amod	_	_
24	serine	serine	NN	NN	_	25	compound	_	_
25	residues	residue	NNS	NNS	_	22	dobj	_	_
26	of	of	IN	IN	_	27	case	_	_
27	IkappaB	ikappab	NN	NN	_	25	nmod	_	_
28	for	for	IN	IN	_	29	case	_	_
29	degradation	degradation	NN	NN	_	22	nmod	_	_
30	.	.	.	.	_	2	punct	_	_

1	Of	of	IN	IN	_	3	case	_	_
2	six	six	CD	CD	_	3	nummod	_	_
3	flavonoids	flavonoid	NNS	NNS	_	8	nmod	_	_
4	tested	test	VBN	VBN	_	3	acl	_	_
5	,	,	,	,	_	8	punct	_	_
6	myricetin	myricetin	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	found	find	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	strongly	strongly	RB	RB	_	11	advmod	_	_
11	inhibit	inhibit	VB	VB	_	8	xcomp	_	_
12	IKK	ikk	NN	NN	_	14	compound	_	_
13	kinase	kinase	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	dobj	_	_
15	,	,	,	,	_	11	punct	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	prevent	prevent	VB	VB	_	11	conj	_	_
18	the	the	DT	DT	_	19	det	_	_
19	degradation	degradation	NN	NN	_	17	dobj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	IkappaBalpha	ikappabalpha	NN	NN	_	19	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	IkappaBbeta	ikappabbeta	NN	NN	_	21	conj	_	_
24	in	in	IN	IN	_	27	case	_	_
25	activated	activate	VBN	VBN	_	27	amod	_	_
26	endothelial	endothelial	JJ	JJ	_	27	amod	_	_
27	cells	cell	NNS	NNS	_	17	nmod	_	_
28	.	.	.	.	_	8	punct	_	_

1	Furthermore	furthermore	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	myricetin	myricetin	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	found	find	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	case	_	_
8	inhibit	inhibit	VB	VB	_	6	advcl	_	_
9	NFkappaB	nfkappab	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	correlated	correlate	VBN	VBN	_	10	acl	_	_
12	with	with	IN	IN	_	13	case	_	_
13	suppression	suppression	NN	NN	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	monocyte	monocyte	NN	NN	_	16	compound	_	_
16	adhesion	adhesion	NN	NN	_	13	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	ECV304	ecv304	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	6	punct	_	_

1	Therefore	therefore	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	conclude	conclude	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	10	mark	_	_
5	flavonoids	flavonoid	NNS	NNS	_	10	nsubj	_	_
6	may	may	MD	MD	_	10	aux	_	_
7	be	be	VB	VB	_	10	cop	_	_
8	of	of	IN	IN	_	10	case	_	_
9	therapeutic	therapeutic	JJ	JJ	_	10	amod	_	_
10	value	value	NN	NN	_	3	ccomp	_	_
11	for	for	IN	IN	_	13	case	_	_
12	vascular	vascular	JJ	JJ	_	13	amod	_	_
13	disease	disease	NN	NN	_	10	nmod	_	_
14	through	through	IN	IN	_	16	case	_	_
15	down	down	JJ	JJ	_	16	amod	_	_
16	regulation	regulation	NN	NN	_	10	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	NFkappaB/IkappaB	nfkappab/ikappab	NN	NN	_	19	compound	_	_
19	system	system	NN	NN	_	16	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	5	compound	_	_
2	1999	1999	CD	CD	_	5	nummod	_	_
3	Wiley-Liss	Wiley-Liss	NNP	NNP	_	5	compound	_	_
4	,	,	,	,	_	5	punct	_	_
5	Inc	Inc	NNP	NNP	_	0	root	_	_
6	.	.	.	.	_	5	punct	_	_

1	-LSB-	-lsb-	-LRB-	-LRB-	_	4	punct	_	_
2	Hormonal	hormonal	JJ	JJ	_	4	amod	_	_
3	metabolic	metabolic	JJ	JJ	_	4	amod	_	_
4	status	status	NN	NN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	breast	breast	NN	NN	_	8	compound	_	_
7	cancer	cancer	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	4	nmod	_	_
9	after	after	IN	IN	_	11	case	_	_
10	conservative	conservative	JJ	JJ	_	11	amod	_	_
11	surgery	surgery	NN	NN	_	4	nmod	_	_
12	:	:	:	:	_	4	punct	_	_
13	comparison	comparison	NN	NN	_	4	dep	_	_
14	with	with	IN	IN	_	17	case	_	_
15	known	known	JJ	JJ	_	17	amod	_	_
16	prognostic	prognostic	JJ	JJ	_	17	amod	_	_
17	criteria	criterion	NNS	NNS	_	13	nmod	_	_
18	-RSB-	-rsb-	-RRB-	-RRB-	_	13	punct	_	_

1	Body	body	NN	NN	_	2	compound	_	_
2	weight	weight	NN	NN	_	53	nsubjpass	_	_
3	,	,	,	,	_	2	punct	_	_
4	body	body	NN	NN	_	6	compound	_	_
5	mass	mass	NN	NN	_	6	compound	_	_
6	index	index	NN	NN	_	2	conj	_	_
7	,	,	,	,	_	2	punct	_	_
8	body	body	NN	NN	_	9	compound	_	_
9	fat	fat	NN	NN	_	2	conj	_	_
10	,	,	,	,	_	2	punct	_	_
11	lean	lean	JJ	JJ	_	13	amod	_	_
12	body	body	NN	NN	_	13	compound	_	_
13	mass	mass	NN	NN	_	2	conj	_	_
14	,	,	,	,	_	2	punct	_	_
15	blood-glucose	blood-glucose	NN	NN	_	2	conj	_	_
16	,	,	,	,	_	2	punct	_	_
17	cholesterol	cholesterol	NN	NN	_	2	conj	_	_
18	,	,	,	,	_	2	punct	_	_
19	HDL-cholesterol	hdl-cholesterol	NN	NN	_	2	conj	_	_
20	,	,	,	,	_	2	punct	_	_
21	triglyceride	triglyceride	NN	NN	_	2	conj	_	_
22	,	,	,	,	_	2	punct	_	_
23	beta-lipoproteins	beta-lipoprotein	NNS	NNS	_	2	conj	_	_
24	,	,	,	,	_	2	punct	_	_
25	insulin	insulin	NN	NN	_	2	conj	_	_
26	,	,	,	,	_	2	punct	_	_
27	gonadotropin	gonadotropin	NN	NN	_	2	conj	_	_
28	,	,	,	,	_	2	punct	_	_
29	estradiol	estradiol	NN	NN	_	2	conj	_	_
30	,	,	,	,	_	2	punct	_	_
31	testosterone	testosterone	NN	NN	_	2	conj	_	_
32	,	,	,	,	_	2	punct	_	_
33	SHBG	shbg	NN	NN	_	2	conj	_	_
34	,	,	,	,	_	2	punct	_	_
35	T3	t3	NN	NN	_	2	conj	_	_
36	,	,	,	,	_	2	punct	_	_
37	T4	t4	NN	NN	_	2	conj	_	_
38	and	and	CC	CC	_	2	cc	_	_
39	TSH	tsh	NN	NN	_	40	compound	_	_
40	levels	level	NNS	NNS	_	2	conj	_	_
41	as	as	RB	RB	_	2	cc	_	_
42	well	well	RB	RB	_	41	mwe	_	_
43	as	as	IN	IN	_	41	mwe	_	_
44	estradiol	estradiol	NN	NN	_	2	conj	_	_
45	and	and	CC	CC	_	44	cc	_	_
46	progesterone	progesterone	NN	NN	_	44	conj	_	_
47	receptor	receptor	NN	NN	_	48	compound	_	_
48	levels	level	NNS	NNS	_	44	dep	_	_
49	in	in	IN	IN	_	51	case	_	_
50	excised	excise	VBN	VBN	_	51	amod	_	_
51	tumor	tumor	NN	NN	_	44	nmod	_	_
52	were	be	VBD	VBD	_	53	auxpass	_	_
53	studied	study	VBN	VBN	_	0	root	_	_
54	in	in	IN	IN	_	56	case	_	_
55	40	40	CD	CD	_	56	nummod	_	_
56	patients	patient	NNS	NNS	_	53	nmod	_	_
57	with	with	IN	IN	_	59	case	_	_
58	breast	breast	NN	NN	_	59	compound	_	_
59	cancer	cancer	NN	NN	_	56	nmod	_	_
60	prior	prior	RB	RB	_	63	advmod	_	_
61	to	to	TO	TO	_	63	case	_	_
62	conservative	conservative	JJ	JJ	_	63	amod	_	_
63	treatment	treatment	NN	NN	_	53	advcl	_	_
64	.	.	.	.	_	53	punct	_	_

1	Said	said	NN	NN	_	7	compound	_	_
2	anthropometric	anthropometric	NN	NN	_	7	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	metabolic	metabolic	JJ	JJ	_	2	conj	_	_
5	and	and	CC	CC	_	2	cc	_	_
6	hormonal	hormonal	JJ	JJ	_	2	conj	_	_
7	parameters	parameter	NNS	NNS	_	9	nsubjpass	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	compared	compare	VBN	VBN	_	0	root	_	_
10	with	with	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	index	index	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	lymphocytic	lymphocytic	JJ	JJ	_	15	amod	_	_
15	infiltration	infiltration	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	tumor	tumor	NN	NN	_	15	nmod	_	_
18	selected	select	VBN	VBN	_	17	acl	_	_
19	as	as	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	prognostic	prognostic	JJ	JJ	_	22	amod	_	_
22	factor	factor	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	significant	significant	JJ	JJ	_	3	amod	_	_
3	correlation	correlation	NN	NN	_	19	nsubjpass	_	_
4	between	between	IN	IN	_	7	case	_	_
5	high	high	JJ	JJ	_	7	amod	_	_
6	lymphocytic	lymphocytic	JJ	JJ	_	7	amod	_	_
7	infiltration	infiltration	NN	NN	_	3	nmod	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	2.5	2.5	CD	CD	_	10	nummod	_	_
10	points	point	NNS	NNS	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	,	,	,	,	_	7	punct	_	_
13	low	low	JJ	JJ	_	15	amod	_	_
14	body	body	NN	NN	_	15	compound	_	_
15	mass	mass	NN	NN	_	7	conj	_	_
16	and	and	CC	CC	_	7	cc	_	_
17	fat	fat	NN	NN	_	7	conj	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	identified	identify	VBN	VBN	_	0	root	_	_
20	.	.	.	.	_	19	punct	_	_

1	Also	also	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	smoking	smoking	NN	NN	_	4	nsubj	_	_
4	contributed	contribute	VBD	VBD	_	0	root	_	_
5	to	to	TO	TO	_	6	case	_	_
6	loss	loss	NN	NN	_	4	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	body	body	NN	NN	_	9	compound	_	_
9	mass	mass	NN	NN	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	fat	fat	NN	NN	_	9	conj	_	_
12	;	;	:	:	_	4	punct	_	_
13	however	however	RB	RB	_	16	advmod	_	_
14	,	,	,	,	_	16	punct	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	caused	cause	VBD	VBD	_	4	parataxis	_	_
17	lymphocytic	lymphocytic	JJ	JJ	_	18	amod	_	_
18	infiltration	infiltration	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	rise	rise	VB	VB	_	16	xcomp	_	_
21	.	.	.	.	_	4	punct	_	_

1	Moderate	moderate	JJ	JJ	_	3	amod	_	_
2	body	body	NN	NN	_	3	compound	_	_
3	mass	mass	NN	NN	_	15	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	relatively	relatively	RB	RB	_	8	advmod	_	_
6	low	low	JJ	JJ	_	8	amod	_	_
7	fat	fat	JJ	JJ	_	8	amod	_	_
8	level	level	NN	NN	_	3	conj	_	_
9	and	and	CC	CC	_	3	cc	_	_
10	positive	positive	JJ	JJ	_	12	amod	_	_
11	receptor	receptor	NN	NN	_	12	compound	_	_
12	status	status	NN	NN	_	3	conj	_	_
13	are	be	VBP	VBP	_	15	cop	_	_
14	among	among	IN	IN	_	15	case	_	_
15	factors	factor	NNS	NNS	_	0	root	_	_
16	of	of	IN	IN	_	18	case	_	_
17	good	good	JJ	JJ	_	18	amod	_	_
18	prognosis	prognosis	NN	NN	_	15	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	breast	breast	NN	NN	_	21	compound	_	_
21	cancer	cancer	NN	NN	_	18	nmod	_	_
22	of	of	IN	IN	_	24	case	_	_
23	early	early	JJ	JJ	_	24	amod	_	_
24	stages	stage	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	15	punct	_	_

1	Tumor	tumor	NN	NN	_	4	compound	_	_
2	necrosis	necrosis	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	5	nsubj	_	_
5	decreases	decrease	VBZ	VBZ	_	20	dep	_	_
6	,	,	,	,	_	5	punct	_	_
7	and	and	CC	CC	_	5	cc	_	_
8	interleukin-10	interleukin-10	NN	NN	_	9	nsubj	_	_
9	increases	increase	VBZ	VBZ	_	5	conj	_	_
10	,	,	,	,	_	5	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	sensitivity	sensitivity	NN	NN	_	5	conj	_	_
13	of	of	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	17	case	_	_
17	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
18	:	:	:	:	_	5	punct	_	_
19	potential	potential	JJ	JJ	_	20	amod	_	_
20	regulation	regulation	NN	NN	_	0	root	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	20	nmod	_	_
25	.	.	.	.	_	20	punct	_	_

1	Resistance	resistance	NN	NN	_	7	nsubjpass	_	_
2	to	to	TO	TO	_	4	case	_	_
3	glucocorticoid	glucocorticoid	NN	NN	_	4	compound	_	_
4	therapy	therapy	NN	NN	_	1	nmod	_	_
5	has	have	VBZ	VBZ	_	7	aux	_	_
6	been	be	VBN	VBN	_	7	auxpass	_	_
7	observed	observe	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	autoimmune/inflammatory	autoimmune/inflammatory	JJ	JJ	_	12	amod	_	_
12	diseases	disease	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	7	cc	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	aux	_	_
16	related	related	JJ	JJ	_	7	conj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	inflammatory	inflammatory	JJ	JJ	_	20	amod	_	_
20	process	process	NN	NN	_	16	nmod	_	_
21	itself	itself	PRP	PRP	_	20	nmod:npmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	aim	aim	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	study	study	NN	NN	_	2	nmod	_	_
6	was	be	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	examine	examine	VB	VB	_	6	xcomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	ability	ability	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	15	case	_	_
12	tumor	tumor	NN	NN	_	15	compound	_	_
13	necrosis	necrosis	NN	NN	_	15	compound	_	_
14	factor	factor	NN	NN	_	15	compound	_	_
15	alpha	alpha	NN	NN	_	10	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	TNFalpha	tnfalpha	NN	NN	_	15	dep	_	_
18	,	,	,	,	_	17	punct	_	_
19	a	a	DT	DT	_	21	det	_	_
20	proinflammatory	proinflammatory	JJ	JJ	_	21	amod	_	_
21	cytokine	cytokine	NN	NN	_	17	appos	_	_
22	)	)	-RRB-	-RRB-	_	17	punct	_	_
23	and	and	CC	CC	_	15	cc	_	_
24	interleukin	interleukin	NN	NN	_	26	compound	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	IL	il	NN	NN	_	15	conj	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	-10	-10	CD	CD	_	26	nummod	_	_
29	(	(	-LRB-	-LRB-	_	32	punct	_	_
30	an	a	DT	DT	_	32	det	_	_
31	anti-inflammatory	anti-inflammatory	JJ	JJ	_	32	amod	_	_
32	cytokine	cytokine	NN	NN	_	26	appos	_	_
33	)	)	-RRB-	-RRB-	_	32	punct	_	_
34	to	to	TO	TO	_	36	mark	_	_
35	differentially	differentially	RB	RB	_	36	advmod	_	_
36	regulate	regulate	VB	VB	_	10	acl	_	_
37	the	the	DT	DT	_	38	det	_	_
38	sensitivity	sensitivity	NN	NN	_	36	dobj	_	_
39	of	of	IN	IN	_	41	case	_	_
40	human	human	JJ	JJ	_	41	amod	_	_
41	monocytes/macrophages	monocytes/macrophages	NNS	NNS	_	38	nmod	_	_
42	to	to	TO	TO	_	43	case	_	_
43	glucocorticoids	glucocorticoid	NNS	NNS	_	38	nmod	_	_
44	.	.	.	.	_	6	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	accomplish	accomplish	VB	VB	_	7	advcl	_	_
3	this	this	DT	DT	_	2	dobj	_	_
4	,	,	,	,	_	7	punct	_	_
5	we	we	PRP	PRP	_	7	nsubj	_	_
6	first	first	RB	RB	_	7	advmod	_	_
7	analyzed	analyze	VBD	VBD	_	0	root	_	_
8	the	the	DT	DT	_	9	det	_	_
9	pattern	pattern	NN	NN	_	7	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	TNFalpha	tnfalpha	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-10	il-10	NN	NN	_	11	conj	_	_
14	inhibition	inhibition	NN	NN	_	9	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	dexamethasone	dexamethasone	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	21	case	_	_
18	LPS-stimulated	lps-stimulated	JJ	JJ	_	21	amod	_	_
19	whole-blood	whole-blood	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	cultures	culture	NNS	NNS	_	14	nmod	_	_
22	.	.	.	.	_	7	punct	_	_

1	Second	second	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	modulation	modulation	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	sensitivity	sensitivity	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	12	case	_	_
11	these	these	DT	DT	_	12	det	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	to	to	TO	TO	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	9	nmod	_	_
15	by	by	IN	IN	_	16	case	_	_
16	preincubation	preincubation	NN	NN	_	4	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	TNFalpha	tnfalpha	NN	NN	_	16	nmod	_	_
19	or	or	CC	CC	_	18	cc	_	_
20	IL-10	il-10	NN	NN	_	18	conj	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	measurement	measurement	NN	NN	_	16	conj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	LPS-stimulated	lps-stimulated	JJ	JJ	_	26	amod	_	_
25	IL-6	il-6	NN	NN	_	26	compound	_	_
26	secretion	secretion	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	addition	addition	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	evaluated	evaluate	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	dexamethasone	dexamethasone	NN	NN	_	7	nmod	_	_
10	on	on	IN	IN	_	15	case	_	_
11	phorbolmyristate-acetate-stimulated	phorbolmyristate-acetate-stimulated	JJ	JJ	_	15	amod	_	_
12	IL-1	il-1	NN	NN	_	15	compound	_	_
13	receptor	receptor	NN	NN	_	15	compound	_	_
14	antagonist	antagonist	NN	NN	_	15	compound	_	_
15	secretion	secretion	NN	NN	_	7	nmod	_	_
16	by	by	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	human	human	JJ	JJ	_	22	amod	_	_
19	monocytic	monocytic	JJ	JJ	_	22	amod	_	_
20	cell	cell	NN	NN	_	22	compound	_	_
21	line	line	NN	NN	_	22	compound	_	_
22	U937	u937	NN	NN	_	5	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	Finally	finally	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	17	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	modulation	modulation	NN	NN	_	17	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	corticosensitivity	corticosensitivity	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	15	case	_	_
11	TNFalpha-	tnfalpha-	NN	NN	_	15	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IL-10-pretreated	il-10-pretreated	JJ	JJ	_	11	conj	_	_
14	U937	u937	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	was	be	VBD	VBD	_	17	aux	_	_
17	related	related	JJ	JJ	_	4	ccomp	_	_
18	to	to	TO	TO	_	20	case	_	_
19	a	a	DT	DT	_	20	det	_	_
20	change	change	NN	NN	_	17	nmod	_	_
21	of	of	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	glucocorticoid	glucocorticoid	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	20	nmod	_	_
25	concentration	concentration	NN	NN	_	24	dep	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	affinity	affinity	NN	NN	_	25	conj	_	_
28	.	.	.	.	_	4	punct	_	_

1	Dexamethasone	dexamethasone	NN	NN	_	2	nsubj	_	_
2	had	have	VBD	VBD	_	0	root	_	_
3	different	different	JJ	JJ	_	4	amod	_	_
4	effects	effect	NNS	NNS	_	2	dobj	_	_
5	on	on	IN	IN	_	7	case	_	_
6	LPS-induced	lps-induced	JJ	JJ	_	7	amod	_	_
7	TNFalpha	tnfalpha	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	secretion	secretion	NN	NN	_	7	dep	_	_
11	;	;	:	:	_	2	punct	_	_
12	whereas	whereas	IN	IN	_	14	mark	_	_
13	it	it	PRP	PRP	_	14	nsubj	_	_
14	suppressed	suppress	VBD	VBD	_	2	dep	_	_
15	TNFalpha	tnfalpha	NN	NN	_	14	dobj	_	_
16	in	in	IN	IN	_	19	case	_	_
17	a	a	DT	DT	_	19	det	_	_
18	dose-dependent	dose-dependent	JJ	JJ	_	19	amod	_	_
19	fashion	fashion	NN	NN	_	14	nmod	_	_
20	,	,	,	,	_	2	punct	_	_
21	its	its	PRP$	PRP$	_	22	nmod:poss	_	_
22	effect	effect	NN	NN	_	27	nsubj	_	_
23	on	on	IN	IN	_	25	case	_	_
24	IL-10	il-10	NN	NN	_	25	compound	_	_
25	secretion	secretion	NN	NN	_	22	nmod	_	_
26	was	be	VBD	VBD	_	27	cop	_	_
27	biphasic	biphasic	JJ	JJ	_	2	parataxis	_	_
28	,	,	,	,	_	27	punct	_	_
29	producing	produce	VBG	VBG	_	27	dep	_	_
30	stimulation	stimulation	NN	NN	_	29	dobj	_	_
31	at	at	IN	IN	_	32	case	_	_
32	lower	lower	JJR	JJR	_	30	acl	_	_
33	,	,	,	,	_	30	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	inhibition	inhibition	NN	NN	_	30	conj	_	_
36	at	at	IN	IN	_	38	case	_	_
37	higher	higher	JJR	JJR	_	38	dep	_	_
38	doses	dose	NNS	NNS	_	30	acl	_	_
39	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	concentration	concentration	NN	NN	_	6	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	LPS	lps	NN	NN	_	2	nmod	_	_
5	employed	employ	VBN	VBN	_	4	acl	_	_
6	influenced	influence	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	dexamethasone	dexamethasone	NN	NN	_	8	nmod	_	_
11	on	on	IN	IN	_	13	case	_	_
12	IL-10	il-10	NN	NN	_	13	compound	_	_
13	secretion	secretion	NN	NN	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	17	punct	_	_
15	P	p	NN	NN	_	17	nsubj	_	_
16	&lt;	&lt;	JJR	JJR	_	17	dep	_	_
17	0.001	0.001	CD	CD	_	13	dep	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	6	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	4	nsubj	_	_
2	with	with	IN	IN	_	3	case	_	_
3	TNFalpha	tnfalpha	NN	NN	_	1	nmod	_	_
4	diminished	diminish	VBD	VBD	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	and	and	CC	CC	_	4	cc	_	_
7	with	with	IN	IN	_	8	case	_	_
8	IL-10	il-10	NN	NN	_	9	nsubj	_	_
9	improved	improve	VBD	VBD	_	4	conj	_	_
10	,	,	,	,	_	9	punct	_	_
11	the	the	DT	DT	_	12	det	_	_
12	ability	ability	NN	NN	_	4	dep	_	_
13	of	of	IN	IN	_	14	case	_	_
14	dexamethasone	dexamethasone	NN	NN	_	12	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	suppress	suppress	VB	VB	_	12	dep	_	_
17	IL-6	il-6	NN	NN	_	18	compound	_	_
18	secretion	secretion	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	whole-blood	whole-blood	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	cultures	culture	NNS	NNS	_	16	nmod	_	_
23	(	(	-LRB-	-LRB-	_	26	punct	_	_
24	P	p	NN	NN	_	26	nsubj	_	_
25	&lt;	&lt;	JJR	JJR	_	26	dep	_	_
26	0.01	0.01	CD	CD	_	16	parataxis	_	_
27	for	for	IN	IN	_	28	case	_	_
28	both	both	DT	DT	_	26	nmod	_	_
29	)	)	-RRB-	-RRB-	_	26	punct	_	_
30	and	and	CC	CC	_	16	cc	_	_
31	to	to	TO	TO	_	32	mark	_	_
32	enhance	enhance	VB	VB	_	16	conj	_	_
33	IL-1	il-1	NN	NN	_	36	compound	_	_
34	receptor	receptor	NN	NN	_	36	compound	_	_
35	antagonist	antagonist	NN	NN	_	36	compound	_	_
36	secretion	secretion	NN	NN	_	32	dobj	_	_
37	by	by	IN	IN	_	39	case	_	_
38	U937	u937	NN	NN	_	39	compound	_	_
39	cells	cell	NNS	NNS	_	32	nmod	_	_
40	(	(	-LRB-	-LRB-	_	43	punct	_	_
41	P	p	NN	NN	_	43	nsubj	_	_
42	&lt;	&lt;	JJR	JJR	_	43	dep	_	_
43	0.05	0.05	CD	CD	_	32	parataxis	_	_
44	for	for	IN	IN	_	45	case	_	_
45	both	both	DT	DT	_	43	nmod	_	_
46	)	)	-RRB-	-RRB-	_	43	punct	_	_
47	.	.	.	.	_	4	punct	_	_

1	TNFalpha	tnfalpha	NN	NN	_	2	nsubj	_	_
2	decreased	decrease	VBD	VBD	_	0	root	_	_
3	(	(	-LRB-	-LRB-	_	6	punct	_	_
4	P	p	NN	NN	_	6	nsubj	_	_
5	&lt;	&lt;	JJR	JJR	_	6	dep	_	_
6	0.001	0.001	CD	CD	_	2	parataxis	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	,	,	,	,	_	2	punct	_	_
9	while	while	IN	IN	_	11	mark	_	_
10	IL-10	il-10	NN	NN	_	11	nsubj	_	_
11	increased	increase	VBD	VBD	_	2	advcl	_	_
12	(	(	-LRB-	-LRB-	_	15	punct	_	_
13	P	p	NN	NN	_	15	nsubj	_	_
14	&lt;	&lt;	JJR	JJR	_	15	dep	_	_
15	0.001	0.001	CD	CD	_	11	parataxis	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	,	,	,	,	_	11	punct	_	_
18	the	the	DT	DT	_	19	det	_	_
19	concentration	concentration	NN	NN	_	11	dobj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	dexamethasone	dexamethasone	NN	NN	_	23	compound	_	_
22	binding	binding	NN	NN	_	23	compound	_	_
23	sites	site	NNS	NNS	_	19	nmod	_	_
24	in	in	IN	IN	_	26	case	_	_
25	these	these	DT	DT	_	26	det	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	,	,	,	,	_	11	punct	_	_
28	with	with	IN	IN	_	31	case	_	_
29	no	no	DT	DT	_	31	neg	_	_
30	discernible	discernible	JJ	JJ	_	31	amod	_	_
31	effect	effect	NN	NN	_	11	nmod	_	_
32	on	on	IN	IN	_	35	case	_	_
33	their	they	PRP$	PRP$	_	35	nmod:poss	_	_
34	binding	binding	NN	NN	_	35	compound	_	_
35	affinity	affinity	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	2	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	conclude	conclude	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	glucocorticoids	glucocorticoid	NNS	NNS	_	6	nsubj	_	_
5	differentially	differentially	RB	RB	_	6	advmod	_	_
6	modulate	modulate	VBP	VBP	_	2	ccomp	_	_
7	TNFalpha	tnfalpha	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	IL-10	il-10	NN	NN	_	7	conj	_	_
10	secretion	secretion	NN	NN	_	7	dep	_	_
11	by	by	IN	IN	_	13	case	_	_
12	human	human	JJ	JJ	_	13	amod	_	_
13	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
14	in	in	IN	IN	_	18	case	_	_
15	a	a	DT	DT	_	18	det	_	_
16	LPS	lps	NN	NN	_	18	compound	_	_
17	dose-dependent	dose-dependent	JJ	JJ	_	18	amod	_	_
18	fashion	fashion	NN	NN	_	6	nmod	_	_
19	and	and	CC	CC	_	6	cc	_	_
20	that	that	IN	IN	_	29	mark	_	_
21	the	the	DT	DT	_	22	det	_	_
22	sensitivity	sensitivity	NN	NN	_	29	nsubjpass	_	_
23	of	of	IN	IN	_	25	case	_	_
24	these	these	DT	DT	_	25	det	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	to	to	TO	TO	_	27	case	_	_
27	glucocorticoids	glucocorticoid	NNS	NNS	_	22	nmod	_	_
28	is	be	VBZ	VBZ	_	29	auxpass	_	_
29	altered	alter	VBN	VBN	_	6	conj	_	_
30	by	by	IN	IN	_	31	case	_	_
31	TNFalpha	tnfalpha	NN	NN	_	29	nmod	_	_
32	or	or	CC	CC	_	31	cc	_	_
33	IL-10	il-10	NN	NN	_	31	conj	_	_
34	pretreatment	pretreatment	NN	NN	_	31	dep	_	_
35	;	;	:	:	_	29	punct	_	_
36	TNFalpha	tnfalpha	NN	NN	_	37	nsubj	_	_
37	blocks	block	VBZ	VBZ	_	29	parataxis	_	_
38	their	they	PRP$	PRP$	_	39	nmod:poss	_	_
39	effects	effect	NNS	NNS	_	37	dobj	_	_
40	,	,	,	,	_	37	punct	_	_
41	whereas	whereas	IN	IN	_	37	dep	_	_
42	IL-10	il-10	NN	NN	_	43	nsubj	_	_
43	acts	act	VBZ	VBZ	_	37	parataxis	_	_
44	synergistically	synergistically	RB	RB	_	43	advmod	_	_
45	with	with	IN	IN	_	46	case	_	_
46	glucocorticoids	glucocorticoid	NNS	NNS	_	43	nmod	_	_
47	.	.	.	.	_	2	punct	_	_

1	This	this	DT	DT	_	3	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	3	auxpass	_	_
3	accompanied	accompany	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	8	case	_	_
5	opposite	opposite	JJ	JJ	_	8	amod	_	_
6	glucocorticoid	glucocorticoid	NN	NN	_	8	compound	_	_
7	receptor	receptor	NN	NN	_	8	compound	_	_
8	changes	change	NNS	NNS	_	3	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	respectively	respectively	RB	RB	_	11	advmod	_	_
11	opposing	oppose	VBG	VBG	_	8	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	favoring	favor	VBG	VBG	_	11	conj	_	_
14	glucocorticoid	glucocorticoid	NN	NN	_	15	compound	_	_
15	actions	action	NNS	NNS	_	11	dobj	_	_
16	.	.	.	.	_	3	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	pattern	pattern	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	pro-/antiinflammatory	pro-/antiinflammatory	JJ	JJ	_	10	amod	_	_
9	cytokine	cytokine	NN	NN	_	10	compound	_	_
10	secretion	secretion	NN	NN	_	6	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	alter	alter	VB	VB	_	3	ccomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	response	response	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	14	nmod	_	_
17	to	to	TO	TO	_	19	case	_	_
18	glucocorticoid	glucocorticoid	NN	NN	_	19	compound	_	_
19	therapy	therapy	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Transcriptional	transcriptional	JJ	JJ	_	2	amod	_	_
2	inhibition	inhibition	NN	NN	_	0	root	_	_
3	by	by	IN	IN	_	4	case	_	_
4	interleukin-6	interleukin-6	NN	NN	_	2	nmod	_	_
5	of	of	IN	IN	_	11	case	_	_
6	the	the	DT	DT	_	11	det	_	_
7	class	class	NN	NN	_	11	compound	_	_
8	A	a	NN	NN	_	11	compound	_	_
9	macrophage	macrophage	NN	NN	_	11	compound	_	_
10	scavenger	scavenger	NN	NN	_	11	compound	_	_
11	receptor	receptor	NN	NN	_	4	nmod	_	_
12	in	in	IN	IN	_	13	case	_	_
13	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
14	derived	derive	VBN	VBN	_	13	amod	_	_
15	from	from	IN	IN	_	18	case	_	_
16	human	human	JJ	JJ	_	18	amod	_	_
17	peripheral	peripheral	JJ	JJ	_	18	amod	_	_
18	monocytes	monocyte	NNS	NNS	_	14	nmod	_	_
19	and	and	CC	CC	_	11	cc	_	_
20	the	the	DT	DT	_	24	det	_	_
21	THP-1	thp-1	NN	NN	_	24	compound	_	_
22	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	line	line	NN	NN	_	11	conj	_	_
25	.	.	.	.	_	2	punct	_	_

1	Expression	expression	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	10	case	_	_
3	the	the	DT	DT	_	10	det	_	_
4	class	class	NN	NN	_	10	compound	_	_
5	A	a	NN	NN	_	10	compound	_	_
6	macrophage	macrophage	NN	NN	_	10	compound	_	_
7	scavenger	scavenger	NN	NN	_	10	compound	_	_
8	receptor	receptor	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	MSR	msr	NN	NN	_	1	nmod	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	contributes	contribute	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	dep	_	_
15	uptake	uptake	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	modified	modify	VBN	VBN	_	22	amod	_	_
18	low	low	JJ	JJ	_	22	amod	_	_
19	density	density	NN	NN	_	22	compound	_	_
20	lipoproteins	lipoprotein	NNS	NNS	_	22	compound	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	LDL	ldl	NN	NN	_	15	nmod	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	by	by	IN	IN	_	25	case	_	_
25	macrophages	macrophage	NNS	NNS	_	15	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	transformation	transformation	NN	NN	_	15	conj	_	_
28	of	of	IN	IN	_	30	case	_	_
29	these	these	DT	DT	_	30	det	_	_
30	cells	cell	NNS	NNS	_	27	nmod	_	_
31	into	into	IN	IN	_	34	case	_	_
32	lipid-laden	lipid-laden	JJ	JJ	_	34	amod	_	_
33	foam	foam	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	27	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	which	which	WDT	WDT	_	37	nsubj	_	_
37	characterize	characterize	VBP	VBP	_	34	acl:relcl	_	_
38	atherosclerosis	atherosclerosis	NN	NN	_	37	dobj	_	_
39	.	.	.	.	_	12	punct	_	_

1	Many	many	JJ	JJ	_	3	amod	_	_
2	environmental	environmental	JJ	JJ	_	3	amod	_	_
3	factors	factor	NNS	NNS	_	15	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	in	in	IN	IN	_	6	case	_	_
6	particular	particular	JJ	JJ	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	proinflammatory	proinflammatory	JJ	JJ	_	9	amod	_	_
9	cytokines	cytokine	NNS	NNS	_	3	appos	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	growth	growth	NN	NN	_	12	compound	_	_
12	factors	factor	NNS	NNS	_	9	conj	_	_
13	,	,	,	,	_	3	punct	_	_
14	can	can	MD	MD	_	15	aux	_	_
15	exert	exert	VB	VB	_	0	root	_	_
16	regulatory	regulatory	JJ	JJ	_	17	amod	_	_
17	effects	effect	NNS	NNS	_	15	dobj	_	_
18	on	on	IN	IN	_	20	case	_	_
19	MSR	msr	NN	NN	_	20	compound	_	_
20	expression	expression	NN	NN	_	15	nmod	_	_
21	,	,	,	,	_	15	punct	_	_
22	whereas	whereas	IN	IN	_	15	dep	_	_
23	intracellular	intracellular	JJ	JJ	_	24	amod	_	_
24	accumulation	accumulation	NN	NN	_	30	nsubj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	cholesterol	cholesterol	NN	NN	_	24	nmod	_	_
27	itself	itself	PRP	PRP	_	26	nmod:npmod	_	_
28	does	do	VBZ	VBZ	_	30	aux	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	influence	influence	VB	VB	_	15	parataxis	_	_
31	MSR	msr	JJ	JJ	_	32	amod	_	_
32	levels	level	NNS	NNS	_	30	dobj	_	_
33	to	to	TO	TO	_	36	case	_	_
34	any	any	DT	DT	_	36	det	_	_
35	considerable	considerable	JJ	JJ	_	36	amod	_	_
36	extent	extent	NN	NN	_	30	nmod	_	_
37	.	.	.	.	_	15	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	present	present	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	14	nmod	_	_
5	,	,	,	,	_	14	punct	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	using	use	VBG	VBG	_	14	advcl	_	_
8	an	a	DT	DT	_	11	det	_	_
9	in	in	FW	FW	_	11	amod	_	_
10	vitro	vitro	FW	FW	_	9	dep	_	_
11	model	model	NN	NN	_	7	dobj	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	examined	examine	VBD	VBD	_	0	root	_	_
15	whether	whether	IN	IN	_	29	mark	_	_
16	stimulation	stimulation	NN	NN	_	29	nsubj	_	_
17	with	with	IN	IN	_	20	case	_	_
18	interleukin-6	interleukin-6	NN	NN	_	20	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IL-6	il-6	NN	NN	_	16	nmod	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	20	punct	_	_
23	an	a	DT	DT	_	27	det	_	_
24	immunoregulatory	immunoregulatory	JJ	JJ	_	27	amod	_	_
25	,	,	,	,	_	27	punct	_	_
26	multipotential	multipotential	JJ	JJ	_	27	amod	_	_
27	cytokine	cytokine	NN	NN	_	20	appos	_	_
28	,	,	,	,	_	16	punct	_	_
29	modulates	modulate	VBZ	VBZ	_	14	ccomp	_	_
30	the	the	DT	DT	_	31	det	_	_
31	expression	expression	NN	NN	_	29	dobj	_	_
32	and	and	CC	CC	_	31	cc	_	_
33	activities	activity	NNS	NNS	_	31	conj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	MSR	msr	NN	NN	_	31	nmod	_	_
37	in	in	IN	IN	_	38	case	_	_
38	macrophages	macrophage	NNS	NNS	_	36	nmod	_	_
39	.	.	.	.	_	14	punct	_	_

1	When	when	WRB	WRB	_	2	advmod	_	_
2	treated	treat	VBN	VBN	_	22	advcl	_	_
3	with	with	IN	IN	_	4	case	_	_
4	IL-6	il-6	NN	NN	_	2	nmod	_	_
5	,	,	,	,	_	22	punct	_	_
6	macrophages	macrophage	NNS	NNS	_	22	nsubj	_	_
7	derived	derive	VBN	VBN	_	6	amod	_	_
8	from	from	IN	IN	_	10	case	_	_
9	peripheral	peripheral	JJ	JJ	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	phorbol	phorbol	NN	NN	_	21	compound	_	_
13	12-myristate	12-myristate	NN	NN	_	21	compound	_	_
14	13-acetate	13-acetate	NN	NN	_	21	compound	_	_
15	(	(	-LRB-	-LRB-	_	21	punct	_	_
16	PMA	pma	NN	NN	_	21	compound	_	_
17	)	)	-RRB-	-RRB-	_	21	punct	_	_
18	-differentiated	-differentiated	JJ	JJ	_	21	amod	_	_
19	THP-1	thp-1	NN	NN	_	21	compound	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	10	conj	_	_
22	showed	show	VBD	VBD	_	0	root	_	_
23	significantly	significantly	RB	RB	_	24	advmod	_	_
24	reduced	reduce	VBN	VBN	_	25	amod	_	_
25	uptake	uptake	NN	NN	_	22	dobj	_	_
26	and/or	and/or	CC	CC	_	25	cc	_	_
27	binding	binding	NN	NN	_	25	conj	_	_
28	of	of	IN	IN	_	31	case	_	_
29	the	the	DT	DT	_	31	det	_	_
30	MSR	msr	NN	NN	_	31	compound	_	_
31	ligand	ligand	NN	NN	_	25	nmod	_	_
32	,	,	,	,	_	31	punct	_	_
33	acetylated	acetylate	VBN	VBN	_	34	amod	_	_
34	LDL	ldl	NN	NN	_	31	appos	_	_
35	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	effect	effect	NN	NN	_	3	nsubj	_	_
3	was	be	VBD	VBD	_	0	root	_	_
4	paralleled	parallel	VBN	VBN	_	3	dep	_	_
5	by	by	IN	IN	_	3	dep	_	_
6	a	a	DT	DT	_	3	dep	_	_
7	reduction	reduction	NN	NN	_	3	dep	_	_
8	in	in	IN	IN	_	3	dep	_	_
9	the	the	DT	DT	_	3	dep	_	_
10	expression	expression	NN	NN	_	3	dep	_	_
11	of	of	IN	IN	_	3	dep	_	_
12	MSR	msr	NN	NN	_	3	dep	_	_
13	protein	protein	NN	NN	_	3	dep	_	_
14	and	and	CC	CC	_	3	cc	_	_
15	mRNA	mrna	NN	NN	_	3	conj	_	_
16	.	.	.	.	_	3	punct	_	_

1	Analysis	analysis	NN	NN	_	16	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	MSR	msr	NN	NN	_	5	compound	_	_
4	promoter	promoter	NN	NN	_	5	compound	_	_
5	activity	activity	NN	NN	_	1	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	THP-1	thp-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	transfected	transfect	VBN	VBN	_	8	acl	_	_
10	with	with	IN	IN	_	15	case	_	_
11	an	a	DT	DT	_	15	det	_	_
12	MSR	msr	NN	NN	_	15	compound	_	_
13	promoter-reporter	promoter-reporter	JJ	JJ	_	15	amod	_	_
14	gene	gene	NN	NN	_	15	compound	_	_
15	construct	construct	NN	NN	_	9	nmod	_	_
16	demonstrated	demonstrate	VBD	VBD	_	0	root	_	_
17	decreased	decrease	VBN	VBN	_	18	amod	_	_
18	activity	activity	NN	NN	_	16	dobj	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	MSR	msr	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	18	nmod	_	_
23	in	in	IN	IN	_	26	case	_	_
24	IL-6-treated	il-6-treated	JJ	JJ	_	26	amod	_	_
25	THP-1	thp-1	NN	NN	_	26	compound	_	_
26	macrophages	macrophage	NNS	NNS	_	18	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
2	mobility	mobility	NN	NN	_	5	compound	_	_
3	gel	gel	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assay	assay	NN	NN	_	7	nsubj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	reduction	reduction	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	binding	binding	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factor	factor	NN	NN	_	12	nmod	_	_
17	to	to	TO	TO	_	22	case	_	_
18	the	the	DT	DT	_	22	det	_	_
19	MSR	msr	NN	NN	_	22	compound	_	_
20	promoter	promoter	NN	NN	_	22	compound	_	_
21	AP-1/ets	ap-1/ets	NN	NN	_	22	compound	_	_
22	elements	element	NNS	NNS	_	12	nmod	_	_
23	in	in	IN	IN	_	25	case	_	_
24	IL-6-treated	il-6-treated	JJ	JJ	_	25	amod	_	_
25	cells	cell	NNS	NNS	_	12	nmod	_	_
26	.	.	.	.	_	7	punct	_	_

1	Thus	thus	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	exposure	exposure	NN	NN	_	7	nsubj	_	_
4	to	to	TO	TO	_	5	case	_	_
5	IL-6	il-6	NN	NN	_	3	nmod	_	_
6	may	may	MD	MD	_	7	aux	_	_
7	inhibit	inhibit	VB	VB	_	0	root	_	_
8	expression	expression	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	class	class	NN	NN	_	13	compound	_	_
12	A	a	NN	NN	_	13	compound	_	_
13	MSR	msr	NN	NN	_	8	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	differentiated	differentiate	VBN	VBN	_	16	amod	_	_
16	macrophages	macrophage	NNS	NNS	_	8	nmod	_	_
17	at	at	IN	IN	_	19	case	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	levels	level	NNS	NNS	_	8	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	result	result	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	this	this	DT	DT	_	6	det	_	_
6	cytokine	cytokine	NN	NN	_	8	nsubj	_	_
7	may	may	MD	MD	_	8	aux	_	_
8	modulate	modulate	VB	VB	_	3	ccomp	_	_
9	foam	foam	NN	NN	_	11	compound	_	_
10	cell	cell	NN	NN	_	11	compound	_	_
11	formation	formation	NN	NN	_	8	dobj	_	_
12	during	during	IN	IN	_	13	case	_	_
13	atherogenesis	atherogenesis	NN	NN	_	8	nmod	_	_
14	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	a	a	DT	DT	_	7	det	_	_
4	functional	functional	JJ	JJ	_	7	amod	_	_
5	vitamin	vitamin	NN	NN	_	7	compound	_	_
6	D	d	NN	NN	_	7	compound	_	_
7	receptor	receptor	NN	NN	_	1	nmod	_	_
8	in	in	IN	IN	_	12	case	_	_
9	all-trans-retinoic	all-trans-retinoic	JJ	JJ	_	12	amod	_	_
10	acid-induced	acid-induced	JJ	JJ	_	12	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	12	amod	_	_
12	differentiation	differentiation	NN	NN	_	1	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	M2-type	m2-type	JJ	JJ	_	17	amod	_	_
15	leukemic	leukemic	JJ	JJ	_	17	amod	_	_
16	blast	blast	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	.	.	.	.	_	1	punct	_	_

1	Different	different	JJ	JJ	_	2	amod	_	_
2	types	type	NNS	NNS	_	10	nsubjpass	_	_
3	of	of	IN	IN	_	8	case	_	_
4	acute	acute	JJ	JJ	_	8	amod	_	_
5	myeloid	myeloid	JJ	JJ	_	8	amod	_	_
6	leukemia	leukemia	NN	NN	_	8	compound	_	_
7	blast	blast	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	2	nmod	_	_
9	were	be	VBD	VBD	_	10	auxpass	_	_
10	induced	induce	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	differentiate	differentiate	VB	VB	_	10	xcomp	_	_
13	in	in	FW	FW	_	14	compound	_	_
14	vitro	vitro	FW	FW	_	12	advmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	all-trans-retinoic	all-trans-retinoic	JJ	JJ	_	17	amod	_	_
17	acid	acid	NN	NN	_	12	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	ATRA	atra	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	17	cc	_	_
22	vitamin	vitamin	NN	NN	_	23	compound	_	_
23	D3	d3	NN	NN	_	17	conj	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	VD	vd	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	.	.	.	.	_	10	punct	_	_

1	M0/M1	m0/m1	NN	NN	_	3	compound	_	_
2	leukemic	leukemic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	not	not	RB	RB	_	6	neg	_	_
6	sensitive	sensitive	JJ	JJ	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	differentiating	differentiate	VBG	VBG	_	9	amod	_	_
9	agents	agent	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	whereas	whereas	IN	IN	_	6	dep	_	_
12	M3	m3	NN	NN	_	14	compound	_	_
13	leukemic	leukemic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	16	nsubjpass	_	_
15	are	be	VBP	VBP	_	16	auxpass	_	_
16	induced	induce	VBN	VBN	_	6	parataxis	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	undergo	undergo	VB	VB	_	16	xcomp	_	_
19	granulocytic	granulocytic	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	18	dobj	_	_
21	after	after	IN	IN	_	23	case	_	_
22	ATRA	atra	NN	NN	_	23	compound	_	_
23	treatment	treatment	NN	NN	_	18	nmod	_	_
24	but	but	CC	CC	_	16	cc	_	_
25	are	be	VBP	VBP	_	27	cop	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	sensitive	sensitive	JJ	JJ	_	16	conj	_	_
28	to	to	TO	TO	_	29	case	_	_
29	VD	vd	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	6	punct	_	_

1	M2	m2	NN	NN	_	4	compound	_	_
2	leukemic	leukemic	JJ	JJ	_	4	amod	_	_
3	blast	blast	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	5	nsubj	_	_
5	behave	behave	VBP	VBP	_	0	root	_	_
6	differently	differently	RB	RB	_	5	advmod	_	_
7	because	because	IN	IN	_	9	mark	_	_
8	they	they	PRP	PRP	_	9	nsubj	_	_
9	undergo	undergo	VBP	VBP	_	5	advcl	_	_
10	monocytic	monocytic	JJ	JJ	_	11	amod	_	_
11	differentiation	differentiation	NN	NN	_	9	dobj	_	_
12	with	with	IN	IN	_	16	case	_	_
13	both	both	DT	DT	_	16	det:predet	_	_
14	the	the	DT	DT	_	16	det	_	_
15	differentiation	differentiation	NN	NN	_	16	compound	_	_
16	inducers	inducer	NNS	NNS	_	9	nmod	_	_
17	.	.	.	.	_	5	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	gain	gain	VB	VB	_	14	advcl	_	_
3	some	some	DT	DT	_	4	det	_	_
4	insight	insight	NN	NN	_	2	dobj	_	_
5	into	into	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	maturation	maturation	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	M2-type	m2-type	JJ	JJ	_	11	amod	_	_
10	leukemic	leukemic	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	,	,	,	,	_	14	punct	_	_
13	we	we	PRP	PRP	_	14	nsubj	_	_
14	studied	study	VBD	VBD	_	0	root	_	_
15	the	the	DT	DT	_	17	det	_	_
16	molecular	molecular	JJ	JJ	_	17	amod	_	_
17	mechanisms	mechanism	NNS	NNS	_	14	dobj	_	_
18	underlying	underlie	VBG	VBG	_	17	acl	_	_
19	monocytic	monocytic	JJ	JJ	_	20	amod	_	_
20	differentiation	differentiation	NN	NN	_	18	dobj	_	_
21	induced	induce	VBN	VBN	_	20	acl	_	_
22	by	by	IN	IN	_	23	case	_	_
23	ATRA	atra	NN	NN	_	21	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	VD	vd	NN	NN	_	23	conj	_	_
26	in	in	IN	IN	_	30	case	_	_
27	spontaneous	spontaneous	JJ	JJ	_	30	amod	_	_
28	M2	m2	NN	NN	_	30	compound	_	_
29	blast	blast	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	21	nmod	_	_
31	as	as	RB	RB	_	30	cc	_	_
32	well	well	RB	RB	_	31	mwe	_	_
33	as	as	IN	IN	_	31	mwe	_	_
34	in	in	IN	IN	_	36	case	_	_
35	Kasumi-1	kasumi-1	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	30	conj	_	_
37	(	(	-LRB-	-LRB-	_	44	punct	_	_
38	an	a	DT	DT	_	44	det	_	_
39	acute	acute	JJ	JJ	_	44	amod	_	_
40	myeloid	myeloid	JJ	JJ	_	44	amod	_	_
41	leukemia	leukemia	NN	NN	_	44	compound	_	_
42	M2-type	m2-type	JJ	JJ	_	44	amod	_	_
43	cell	cell	NN	NN	_	44	compound	_	_
44	line	line	NN	NN	_	36	appos	_	_
45	)	)	-RRB-	-RRB-	_	44	punct	_	_
46	.	.	.	.	_	14	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	ATRA	atra	NN	NN	_	11	nsubj	_	_
6	as	as	RB	RB	_	5	cc	_	_
7	well	well	RB	RB	_	6	mwe	_	_
8	as	as	IN	IN	_	6	mwe	_	_
9	VD	vd	NN	NN	_	5	conj	_	_
10	efficiently	efficiently	RB	RB	_	11	advmod	_	_
11	increases	increase	VBZ	VBZ	_	3	ccomp	_	_
12	the	the	DT	DT	_	14	det	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	abundance	abundance	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	VD	vd	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	14	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	VDR	vdr	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	11	cc	_	_
22	promotes	promote	VBZ	VBZ	_	11	conj	_	_
23	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	22	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	VDR	vdr	NN	NN	_	4	nsubj	_	_
2	is	be	VBZ	VBZ	_	4	cop	_	_
3	functionally	functionally	RB	RB	_	4	advmod	_	_
4	active	active	JJ	JJ	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	ATRA-treated	atra-treated	JJ	JJ	_	8	amod	_	_
7	Kasumi-1	kasumi-1	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	4	nmod	_	_
9	because	because	IN	IN	_	12	mark	_	_
10	it	it	PRP	PRP	_	12	nsubj	_	_
11	efficiently	efficiently	RB	RB	_	12	advmod	_	_
12	heterodimerizes	heterodimerize	VBZ	VBZ	_	4	advcl	_	_
13	with	with	IN	IN	_	16	case	_	_
14	retinoid	retinoid	NN	NN	_	16	compound	_	_
15	X	x	NN	NN	_	16	compound	_	_
16	receptor	receptor	NN	NN	_	12	nmod	_	_
17	,	,	,	,	_	12	punct	_	_
18	binds	bind	VBZ	VBZ	_	12	conj	_	_
19	to	to	TO	TO	_	24	case	_	_
20	a	a	DT	DT	_	24	det	_	_
21	DR3-type	dr3-type	JJ	JJ	_	24	amod	_	_
22	vitamin	vitamin	NN	NN	_	24	compound	_	_
23	D-responsive	d-responsive	JJ	JJ	_	24	amod	_	_
24	element	element	NN	NN	_	18	nmod	_	_
25	,	,	,	,	_	12	punct	_	_
26	and	and	CC	CC	_	12	cc	_	_
27	activates	activate	VBZ	VBZ	_	12	conj	_	_
28	the	the	DT	DT	_	29	det	_	_
29	transcription	transcription	NN	NN	_	27	dobj	_	_
30	of	of	IN	IN	_	36	case	_	_
31	a	a	DT	DT	_	36	det	_	_
32	vitamin	vitamin	NN	NN	_	36	compound	_	_
33	D-responsive	d-responsive	JJ	JJ	_	36	amod	_	_
34	element-regulated	element-regulated	JJ	JJ	_	36	amod	_	_
35	reporter	reporter	NN	NN	_	36	compound	_	_
36	gene	gene	NN	NN	_	29	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	Consistent	consistent	JJ	JJ	_	9	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	findings	finding	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	9	punct	_	_
6	VD-responsive	vd-responsive	JJ	JJ	_	7	amod	_	_
7	genes	gene	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	induced	induce	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	ATRA	atra	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	Kasumi-1	kasumi-1	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	suggesting	suggest	VBG	VBG	_	9	xcomp	_	_
18	that	that	IN	IN	_	26	mark	_	_
19	the	the	DT	DT	_	21	det	_	_
20	genetic	genetic	JJ	JJ	_	21	amod	_	_
21	program	program	NN	NN	_	26	nsubjpass	_	_
22	underlying	underlie	VBG	VBG	_	21	acl	_	_
23	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	22	dobj	_	_
25	is	be	VBZ	VBZ	_	26	auxpass	_	_
26	activated	activate	VBN	VBN	_	17	ccomp	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	molecular	molecular	JJ	JJ	_	3	amod	_	_
3	mechanism	mechanism	NN	NN	_	17	nsubj	_	_
4	by	by	IN	IN	_	5	case	_	_
5	which	which	WDT	WDT	_	7	nmod	_	_
6	ATRA	atra	NN	NN	_	7	nsubj	_	_
7	increases	increase	VBZ	VBZ	_	3	acl:relcl	_	_
8	the	the	DT	DT	_	10	det	_	_
9	nuclear	nuclear	JJ	JJ	_	10	amod	_	_
10	abundance	abundance	NN	NN	_	7	dobj	_	_
11	of	of	IN	IN	_	14	case	_	_
12	a	a	DT	DT	_	14	det	_	_
13	functional	functional	JJ	JJ	_	14	amod	_	_
14	VDR	vdr	NN	NN	_	10	nmod	_	_
15	is	be	VBZ	VBZ	_	17	cop	_	_
16	still	still	RB	RB	_	17	advmod	_	_
17	unknown	unknown	JJ	JJ	_	0	root	_	_
18	,	,	,	,	_	17	punct	_	_
19	but	but	CC	CC	_	17	cc	_	_
20	our	we	PRP$	PRP$	_	21	nmod:poss	_	_
21	data	datum	NNS	NNS	_	23	nsubj	_	_
22	clearly	clearly	RB	RB	_	23	advmod	_	_
23	indicate	indicate	VBP	VBP	_	17	conj	_	_
24	that	that	IN	IN	_	32	mark	_	_
25	the	the	DT	DT	_	29	det	_	_
26	M2	m2	NN	NN	_	29	compound	_	_
27	leukemic	leukemic	JJ	JJ	_	29	amod	_	_
28	cell	cell	NN	NN	_	29	compound	_	_
29	context	context	NN	NN	_	32	nsubj	_	_
30	is	be	VBZ	VBZ	_	32	cop	_	_
31	only	only	RB	RB	_	32	advmod	_	_
32	permissive	permissive	JJ	JJ	_	23	ccomp	_	_
33	of	of	IN	IN	_	35	case	_	_
34	monocytic	monocytic	JJ	JJ	_	35	amod	_	_
35	differentiation	differentiation	NN	NN	_	32	nmod	_	_
36	.	.	.	.	_	17	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	responses	response	NNS	NNS	_	0	root	_	_
3	to	to	TO	TO	_	4	case	_	_
4	adenoviruses	adenovirus	NNS	NNS	_	2	nmod	_	_
5	:	:	:	:	_	2	punct	_	_
6	viral	viral	JJ	JJ	_	8	amod	_	_
7	evasion	evasion	NN	NN	_	8	compound	_	_
8	mechanisms	mechanism	NNS	NNS	_	2	dep	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	implications	implication	NNS	NNS	_	8	conj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	clinic	clinic	NN	NN	_	11	nmod	_	_
15	.	.	.	.	_	2	punct	_	_

1	Adenoviruses	adenovirus	NNS	NNS	_	2	nsubj	_	_
2	encode	encode	VBP	VBP	_	0	root	_	_
3	proteins	protein	NNS	NNS	_	2	dobj	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	block	block	VBP	VBP	_	3	acl:relcl	_	_
6	responses	response	NNS	NNS	_	5	dobj	_	_
7	to	to	TO	TO	_	8	case	_	_
8	interferons	interferon	NNS	NNS	_	6	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	intrinsic	intrinsic	JJ	JJ	_	12	amod	_	_
11	cellular	cellular	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	8	appos	_	_
13	,	,	,	,	_	12	punct	_	_
14	killing	killing	NN	NN	_	12	appos	_	_
15	by	by	IN	IN	_	19	case	_	_
16	CD8(+)	cd8(+)	JJ	JJ	_	19	amod	_	_
17	cytotoxic	cytotoxic	JJ	JJ	_	19	amod	_	_
18	T	t	NN	NN	_	19	compound	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	14	nmod	_	_
20	and	and	CC	CC	_	14	cc	_	_
21	killing	killing	NN	NN	_	14	conj	_	_
22	by	by	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	death	death	NN	NN	_	25	compound	_	_
25	ligands	ligand	NNS	NNS	_	21	nmod	_	_
26	TNF	tnf	NN	NN	_	25	dep	_	_
27	,	,	,	,	_	26	punct	_	_
28	Fas	fas	NN	NN	_	29	compound	_	_
29	ligand	ligand	NN	NN	_	26	conj	_	_
30	and	and	CC	CC	_	26	cc	_	_
31	TRAIL	trail	NN	NN	_	26	conj	_	_
32	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	viral	viral	JJ	JJ	_	3	amod	_	_
3	proteins	protein	NNS	NNS	_	5	nsubjpass	_	_
4	are	be	VBP	VBP	_	5	auxpass	_	_
5	believed	believe	VBN	VBN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	prolong	prolong	VB	VB	_	5	xcomp	_	_
8	acute	acute	JJ	JJ	_	12	amod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	persistent	persistent	JJ	JJ	_	8	conj	_	_
11	adenovirus	adenovirus	NN	NN	_	12	compound	_	_
12	infections	infection	NNS	NNS	_	7	dobj	_	_
13	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	proteins	protein	NNS	NNS	_	4	nsubj	_	_
3	may	may	MD	MD	_	4	aux	_	_
4	prove	prove	VB	VB	_	0	root	_	_
5	useful	useful	JJ	JJ	_	4	xcomp	_	_
6	in	in	IN	IN	_	7	mark	_	_
7	protecting	protect	VBG	VBG	_	5	advcl	_	_
8	adenovirus	adenovirus	NN	NN	_	11	compound	_	_
9	gene	gene	NN	NN	_	11	compound	_	_
10	therapy	therapy	NN	NN	_	11	compound	_	_
11	vectors	vector	NNS	NNS	_	7	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	transplanted	transplant	VBN	VBN	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	11	conj	_	_
15	from	from	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	system	system	NN	NN	_	7	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	Myb-transformed	myb-transformed	JJ	JJ	_	3	amod	_	_
2	hematopoietic	hematopoietic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	0	root	_	_
4	as	as	IN	IN	_	6	case	_	_
5	a	a	DT	DT	_	6	det	_	_
6	model	model	NN	NN	_	3	nmod	_	_
7	for	for	IN	IN	_	9	case	_	_
8	monocyte	monocyte	NN	NN	_	9	compound	_	_
9	differentiation	differentiation	NN	NN	_	6	nmod	_	_
10	into	into	IN	IN	_	12	case	_	_
11	dendritic	dendritic	JJ	JJ	_	12	amod	_	_
12	cells	cell	NNS	NNS	_	9	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	macrophages	macrophage	NNS	NNS	_	12	conj	_	_
15	.	.	.	.	_	3	punct	_	_

1	Immune	immune	JJ	JJ	_	2	amod	_	_
2	induction	induction	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	effected	effect	VBN	VBN	_	0	root	_	_
5	through	through	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	interaction	interaction	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	antigen-presenting	antigen-presenting	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	7	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	specific	specific	JJ	JJ	_	13	amod	_	_
13	receptors	receptor	NNS	NNS	_	7	nmod	_	_
14	on	on	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	surface	surface	NN	NN	_	4	nmod	_	_
17	of	of	IN	IN	_	19	case	_	_
18	thymus-derived	thymus-derived	JJ	JJ	_	19	amod	_	_
19	lymphocytes	lymphocyte	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	4	punct	_	_

1	Cells	cell	NNS	NNS	_	12	nsubj	_	_
2	most	most	RBS	RBS	_	3	advmod	_	_
3	able	able	JJ	JJ	_	1	amod	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	ingest	ingest	VB	VB	_	3	xcomp	_	_
6	,	,	,	,	_	5	punct	_	_
7	process	process	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	present	present	VB	VB	_	5	conj	_	_
11	antigen	antigen	NN	NN	_	5	dobj	_	_
12	appear	appear	VBP	VBP	_	0	root	_	_
13	to	to	TO	TO	_	15	mark	_	_
14	be	be	VB	VB	_	15	aux	_	_
15	related	related	JJ	JJ	_	12	xcomp	_	_
16	to	to	TO	TO	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	mononuclear	mononuclear	JJ	JJ	_	20	amod	_	_
19	phagocyte/neutrophil	phagocyte/neutrophil	NN	NN	_	20	compound	_	_
20	series	series	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	12	punct	_	_

1	For	for	IN	IN	_	2	case	_	_
2	example	example	NN	NN	_	10	nmod	_	_
3	dendritic	dendritic	JJ	JJ	_	4	amod	_	_
4	cells	cell	NNS	NNS	_	10	nsubjpass	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	DC	dc	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	can	can	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	auxpass	_	_
10	found	find	VBN	VBN	_	0	root	_	_
11	in	in	IN	IN	_	12	case	_	_
12	colonies	colony	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	17	case	_	_
14	GM-CSF-responsive	gm-csf-responsive	JJ	JJ	_	17	amod	_	_
15	bone	bone	NN	NN	_	17	compound	_	_
16	marrow	marrow	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	12	nmod	_	_
18	,	,	,	,	_	10	punct	_	_
19	and	and	CC	CC	_	10	cc	_	_
20	under	under	IN	IN	_	22	case	_	_
21	experimental	experimental	JJ	JJ	_	22	amod	_	_
22	conditions	condition	NNS	NNS	_	10	conj	_	_
23	are	be	VBP	VBP	_	25	auxpass	_	_
24	routinely	routinely	RB	RB	_	25	advmod	_	_
25	expanded	expand	VBN	VBN	_	10	dep	_	_
26	as	as	IN	IN	_	28	case	_	_
27	a	a	DT	DT	_	28	det	_	_
28	population	population	NN	NN	_	25	nmod	_	_
29	in	in	FW	FW	_	30	compound	_	_
30	vitro	vitro	FW	FW	_	25	advmod	_	_
31	from	from	IN	IN	_	34	case	_	_
32	GM-CSF-responsive	gm-csf-responsive	JJ	JJ	_	34	amod	_	_
33	progenitor	progenitor	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	25	nmod	_	_
35	.	.	.	.	_	10	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	address	address	VB	VB	_	21	ccomp	_	_
3	the	the	DT	DT	_	4	det	_	_
4	question	question	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	DC	dc	NN	NN	_	7	compound	_	_
7	lineage	lineage	NN	NN	_	4	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	determine	determine	VB	VB	_	2	conj	_	_
11	what	what	WP	WP	_	12	det	_	_
12	genes	gene	NNS	NNS	_	14	nsubjpass	_	_
13	are	be	VBP	VBP	_	14	auxpass	_	_
14	involved	involve	VBN	VBN	_	10	ccomp	_	_
15	in	in	IN	IN	_	17	case	_	_
16	lineage	lineage	NN	NN	_	17	compound	_	_
17	commitment	commitment	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	21	punct	_	_
19	we	we	PRP	PRP	_	21	nsubj	_	_
20	have	have	VBP	VBP	_	21	aux	_	_
21	generated	generate	VBN	VBN	_	0	root	_	_
22	a	a	DT	DT	_	23	det	_	_
23	series	series	NN	NN	_	21	dobj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	GM-CSF-responsive	gm-csf-responsive	JJ	JJ	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	lines	line	NNS	NNS	_	23	nmod	_	_
28	that	that	WDT	WDT	_	31	nsubjpass	_	_
29	can	can	MD	MD	_	31	aux	_	_
30	be	be	VB	VB	_	31	auxpass	_	_
31	induced	induce	VBN	VBN	_	27	acl:relcl	_	_
32	to	to	TO	TO	_	33	mark	_	_
33	differentiate	differentiate	VB	VB	_	31	xcomp	_	_
34	in	in	IN	IN	_	37	case	_	_
35	a	a	DT	DT	_	37	det	_	_
36	homogeneous	homogeneous	JJ	JJ	_	37	amod	_	_
37	manner	manner	NN	NN	_	33	nmod	_	_
38	in	in	FW	FW	_	39	compound	_	_
39	vitro	vitro	FW	FW	_	33	advmod	_	_
40	.	.	.	.	_	21	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	cloned	clone	VBN	VBN	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	lines	line	NNS	NNS	_	6	nsubjpass	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	derived	derive	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	10	case	_	_
8	12-day	12-day	JJ	JJ	_	10	amod	_	_
9	fetal	fetal	JJ	JJ	_	10	amod	_	_
10	liver	liver	NN	NN	_	6	nmod	_	_
11	and	and	CC	CC	_	6	cc	_	_
12	are	be	VBP	VBP	_	13	auxpass	_	_
13	transformed	transform	VBN	VBN	_	6	conj	_	_
14	with	with	IN	IN	_	17	case	_	_
15	a	a	DT	DT	_	17	det	_	_
16	truncated	truncate	VBN	VBN	_	17	amod	_	_
17	form	form	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	c-myb	c-myb	NN	NN	_	17	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	which	which	WDT	WDT	_	22	nsubj	_	_
22	lacks	lack	VBZ	VBZ	_	19	acl:relcl	_	_
23	the	the	DT	DT	_	26	det	_	_
24	normal	normal	JJ	JJ	_	26	amod	_	_
25	autoregulatory	autoregulatory	JJ	JJ	_	26	amod	_	_
26	sequences	sequence	NNS	NNS	_	22	dobj	_	_
27	.	.	.	.	_	6	punct	_	_

1	As	as	RB	RB	_	5	advmod	_	_
2	far	far	RB	RB	_	5	advmod	_	_
3	as	as	IN	IN	_	5	mark	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	know	know	VBP	VBP	_	14	advcl	_	_
6	,	,	,	,	_	14	punct	_	_
7	these	these	DT	DT	_	10	det	_	_
8	myb-transformed	myb-transformed	JJ	JJ	_	10	amod	_	_
9	hemopoi-etic	hemopoi-etic	JJ	JJ	_	10	amod	_	_
10	cells	cell	NNS	NNS	_	14	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MTHC	mthc	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	differ	differ	VBP	VBP	_	0	root	_	_
15	from	from	IN	IN	_	16	case	_	_
16	normal	normal	JJ	JJ	_	14	nmod	_	_
17	only	only	RB	RB	_	21	advmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	unregulated	unregulated	JJ	JJ	_	21	amod	_	_
21	expression	expression	NN	NN	_	16	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	myb	myb	NN	NN	_	21	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	a	a	DT	DT	_	26	det	_	_
26	gene	gene	NN	NN	_	23	appos	_	_
27	whose	whose	WP$	WP$	_	28	nmod:poss	_	_
28	expression	expression	NN	NN	_	30	nsubj	_	_
29	is	be	VBZ	VBZ	_	30	cop	_	_
30	obligatory	obligatory	JJ	JJ	_	26	acl:relcl	_	_
31	for	for	IN	IN	_	32	case	_	_
32	proliferation	proliferation	NN	NN	_	30	nmod	_	_
33	of	of	IN	IN	_	35	case	_	_
34	hemopoietic	hemopoietic	JJ	JJ	_	35	amod	_	_
35	cells	cell	NNS	NNS	_	32	nmod	_	_
36	.	.	.	.	_	14	punct	_	_

1	MTHC	mthc	NN	NN	_	10	nsubj	_	_
2	in	in	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	presence	presence	NN	NN	_	10	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	IL-4	il-4	NN	NN	_	6	conj	_	_
9	will	will	MD	MD	_	10	aux	_	_
10	differentiate	differentiate	VB	VB	_	0	root	_	_
11	into	into	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	10	nmod	_	_
13	that	that	WDT	WDT	_	14	nsubj	_	_
14	have	have	VBP	VBP	_	12	acl:relcl	_	_
15	many	many	JJ	JJ	_	14	dobj	_	_
16	of	of	IN	IN	_	18	case	_	_
17	the	the	DT	DT	_	18	det	_	_
18	properties	property	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	macrophages	macrophage	NNS	NNS	_	18	nmod	_	_
21	.	.	.	.	_	10	punct	_	_

1	When	when	WRB	WRB	_	7	advmod	_	_
2	the	the	DT	DT	_	5	det	_	_
3	same	same	JJ	JJ	_	5	amod	_	_
4	MTHC	mthc	NN	NN	_	5	compound	_	_
5	lines	line	NNS	NNS	_	7	nsubjpass	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	exposed	expose	VBN	VBN	_	18	advcl	_	_
8	to	to	TO	TO	_	9	case	_	_
9	TNF-alpha	tnf-alpha	NN	NN	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	combination	combination	NN	NN	_	7	nmod	_	_
12	with	with	IN	IN	_	13	case	_	_
13	IFN-gamma	ifn-gamma	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	18	punct	_	_
15	the	the	DT	DT	_	16	det	_	_
16	cells	cell	NNS	NNS	_	18	nsubj	_	_
17	instead	instead	RB	RB	_	16	advmod	_	_
18	become	become	VBP	VBP	_	0	root	_	_
19	DC	dc	NN	NN	_	18	xcomp	_	_
20	.	.	.	.	_	18	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	differentiated	differentiate	VBN	VBN	_	3	amod	_	_
3	DC	dc	NN	NN	_	6	nsubj	_	_
4	are	be	VBP	VBP	_	6	cop	_	_
5	potent	potent	JJ	JJ	_	6	amod	_	_
6	presenters	presenter	NNS	NNS	_	0	root	_	_
7	of	of	IN	IN	_	8	case	_	_
8	antigen	antigen	NN	NN	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	mixed	mixed	JJ	JJ	_	12	amod	_	_
11	lymphocyte	lymphocyte	NN	NN	_	12	compound	_	_
12	reactions	reaction	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	of	of	IN	IN	_	16	case	_	_
15	soluble	soluble	JJ	JJ	_	16	amod	_	_
16	antigen	antigen	NN	NN	_	8	conj	_	_
17	to	to	TO	TO	_	21	case	_	_
18	specific	specific	JJ	JJ	_	21	amod	_	_
19	T	t	NN	NN	_	21	compound	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	Thus	thus	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	cells	cell	NNS	NNS	_	14	nsubjpass	_	_
4	with	with	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	properties	property	NNS	NNS	_	3	nmod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	both	both	CC	CC	_	9	cc:preconj	_	_
9	macrophages	macrophage	NNS	NNS	_	6	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	DC	dc	NN	NN	_	9	conj	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	derived	derive	VBN	VBN	_	0	root	_	_
15	from	from	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	single	single	JJ	JJ	_	18	amod	_	_
18	type	type	NN	NN	_	14	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	GM-CSF-responsive	gm-csf-responsive	JJ	JJ	_	22	amod	_	_
21	progenitor	progenitor	NN	NN	_	22	compound	_	_
22	cell	cell	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	14	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	used	use	VBN	VBN	_	0	root	_	_
4	this	this	DT	DT	_	6	det	_	_
5	MTHC	mthc	NN	NN	_	6	compound	_	_
6	system	system	NN	NN	_	3	dobj	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	analyze	analyze	VB	VB	_	3	advcl	_	_
9	differences	difference	NNS	NNS	_	8	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	gene	gene	NN	NN	_	12	compound	_	_
12	expression	expression	NN	NN	_	9	nmod	_	_
13	as	as	IN	IN	_	16	mark	_	_
14	the	the	DT	DT	_	15	det	_	_
15	cells	cell	NNS	NNS	_	16	nsubj	_	_
16	mature	mature	VBP	VBP	_	8	advcl	_	_
17	along	along	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	dep	_	_
19	DC	dc	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	macrophage	macrophage	NN	NN	_	22	compound	_	_
22	pathways	pathway	NNS	NNS	_	19	conj	_	_
23	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	distinctive	distinctive	JJ	JJ	_	3	amod	_	_
3	pattern	pattern	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	differentially	differentially	RB	RB	_	6	advmod	_	_
6	expressed	express	VBN	VBN	_	7	amod	_	_
7	cDNAs	cdna	NNS	NNS	_	3	nmod	_	_
8	is	be	VBZ	VBZ	_	9	cop	_	_
9	evident	evident	JJ	JJ	_	0	root	_	_
10	where	where	WRB	WRB	_	14	advmod	_	_
11	macrophage-specific	macrophage-specific	JJ	JJ	_	12	amod	_	_
12	cDNAs	cdna	NNS	NNS	_	14	nsubj	_	_
13	are	be	VBP	VBP	_	14	cop	_	_
14	homologous	homologous	JJ	JJ	_	9	ccomp	_	_
15	to	to	TO	TO	_	16	case	_	_
16	genes	gene	NNS	NNS	_	14	nmod	_	_
17	encoding	encode	VBG	VBG	_	16	acl	_	_
18	cytoskeletal	cytoskeletal	JJ	JJ	_	17	dobj	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	cell-surface	cell-surface	JJ	JJ	_	18	conj	_	_
21	proteins	protein	NNS	NNS	_	18	dep	_	_
22	,	,	,	,	_	9	punct	_	_
23	whereas	whereas	IN	IN	_	9	dep	_	_
24	the	the	DT	DT	_	26	det	_	_
25	DC-specific	dc-specific	JJ	JJ	_	26	amod	_	_
26	cDNAs	cdna	NNS	NNS	_	28	nsubj	_	_
27	are	be	VBP	VBP	_	28	cop	_	_
28	homologous	homologous	JJ	JJ	_	9	parataxis	_	_
29	to	to	TO	TO	_	30	case	_	_
30	signaling	signaling	NN	NN	_	28	nmod	_	_
31	,	,	,	,	_	30	punct	_	_
32	chemokine	chemokine	NN	NN	_	30	conj	_	_
33	,	,	,	,	_	30	punct	_	_
34	and	and	CC	CC	_	30	cc	_	_
35	IFN-gamma-inducible	ifn-gamma-inducible	JJ	JJ	_	30	conj	_	_
36	genes	gene	NNS	NNS	_	30	dep	_	_
37	.	.	.	.	_	9	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	discuss	discuss	VBP	VBP	_	0	root	_	_
3	the	the	DT	DT	_	4	det	_	_
4	utility	utility	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	MTHC	mthc	NN	NN	_	4	acl	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	analyzing	analyze	VBG	VBG	_	4	acl	_	_
9	the	the	DT	DT	_	10	det	_	_
10	relationships	relationship	NNS	NNS	_	8	dobj	_	_
11	between	between	IN	IN	_	12	case	_	_
12	DC	dc	NN	NN	_	10	nmod	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	macrophages	macrophage	NNS	NNS	_	12	conj	_	_
15	,	,	,	,	_	2	punct	_	_
16	and	and	CC	CC	_	2	cc	_	_
17	suggest	suggest	VB	VB	_	2	conj	_	_
18	that	that	IN	IN	_	22	mark	_	_
19	DC	dc	NN	NN	_	22	nsubj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	macrophages	macrophage	NNS	NNS	_	19	conj	_	_
22	represent	represent	VBP	VBP	_	17	ccomp	_	_
23	extreme	extreme	JJ	JJ	_	24	amod	_	_
24	phenotypes	phenotype	NNS	NNS	_	22	dobj	_	_
25	in	in	IN	IN	_	27	case	_	_
26	a	a	DT	DT	_	27	det	_	_
27	spectrum	spectrum	NN	NN	_	22	nmod	_	_
28	of	of	IN	IN	_	31	case	_	_
29	antigen	antigen	NN	NN	_	31	compound	_	_
30	handling	handling	NN	NN	_	31	compound	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	that	that	WDT	WDT	_	35	nsubj	_	_
33	are	be	VBP	VBP	_	35	cop	_	_
34	somewhat	somewhat	RB	RB	_	35	advmod	_	_
35	interchangeable	interchangeable	JJ	JJ	_	31	acl:relcl	_	_
36	,	,	,	,	_	35	punct	_	_
37	depending	depend	VBG	VBG	_	41	case	_	_
38	on	on	IN	IN	_	41	case	_	_
39	their	they	PRP$	PRP$	_	41	nmod:poss	_	_
40	immediate	immediate	JJ	JJ	_	41	amod	_	_
41	environment	environment	NN	NN	_	35	advcl	_	_
42	.	.	.	.	_	2	punct	_	_

1	Dendritic	dendritic	JJ	JJ	_	2	amod	_	_
2	cells	cell	NNS	NNS	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	the	the	DT	DT	_	5	det	_	_
5	pathogenesis	pathogenesis	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	rheumatoid	rheumatoid	JJ	JJ	_	8	amod	_	_
8	arthritis	arthritis	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Rheumatoid	rheumatoid	JJ	JJ	_	2	amod	_	_
2	arthritis	arthritis	NN	NN	_	11	nsubj	_	_
3	(	(	-LRB-	-LRB-	_	4	punct	_	_
4	RA	ra	NN	NN	_	2	appos	_	_
5	)	)	-RRB-	-RRB-	_	4	punct	_	_
6	is	be	VBZ	VBZ	_	11	cop	_	_
7	a	a	DT	DT	_	11	det	_	_
8	chronic	chronic	JJ	JJ	_	11	amod	_	_
9	autoimmune	autoimmune	JJ	JJ	_	11	amod	_	_
10	inflammatory	inflammatory	JJ	JJ	_	11	amod	_	_
11	disease	disease	NN	NN	_	0	root	_	_
12	in	in	IN	IN	_	13	case	_	_
13	which	which	WDT	WDT	_	18	nmod	_	_
14	unknown	unknown	JJ	JJ	_	16	amod	_	_
15	arthrogenic	arthrogenic	JJ	JJ	_	16	amod	_	_
16	autoantigen	autoantigen	NN	NN	_	18	nsubjpass	_	_
17	is	be	VBZ	VBZ	_	18	auxpass	_	_
18	presented	present	VBN	VBN	_	11	acl:relcl	_	_
19	to	to	TO	TO	_	22	case	_	_
20	CD4+	cd4+	JJ	JJ	_	22	amod	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	18	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	strong	strong	JJ	JJ	_	3	amod	_	_
3	association	association	NN	NN	_	22	nsubj	_	_
4	of	of	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	disease	disease	NN	NN	_	3	nmod	_	_
7	with	with	IN	IN	_	9	case	_	_
8	an	a	DT	DT	_	9	det	_	_
9	epitope	epitope	NN	NN	_	3	nmod	_	_
10	within	within	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	HLA-DR	hla-dr	NN	NN	_	13	compound	_	_
13	chain	chain	NN	NN	_	22	nmod	_	_
14	shared	share	VBN	VBN	_	13	acl	_	_
15	between	between	IN	IN	_	17	case	_	_
16	various	various	JJ	JJ	_	17	amod	_	_
17	alleles	allele	NNS	NNS	_	14	nmod	_	_
18	of	of	IN	IN	_	19	case	_	_
19	HLA-DR4	hla-dr4	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	DR1	dr1	NN	NN	_	19	conj	_	_
22	emphasizes	emphasize	VBZ	VBZ	_	0	root	_	_
23	the	the	DT	DT	_	24	det	_	_
24	importance	importance	NN	NN	_	22	dobj	_	_
25	of	of	IN	IN	_	27	case	_	_
26	antigen	antigen	JJ	JJ	_	27	amod	_	_
27	presentation	presentation	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	22	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	immune	immune	JJ	JJ	_	3	amod	_	_
3	response	response	NN	NN	_	5	nsubj	_	_
4	predominantly	predominantly	RB	RB	_	5	advmod	_	_
5	occurs	occur	VBZ	VBZ	_	0	root	_	_
6	in	in	IN	IN	_	9	case	_	_
7	the	the	DT	DT	_	9	dep	_	_
8	synovial	synovial	NN	NN	_	9	compound	_	_
9	tissue	tissue	NN	NN	_	5	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	fluid	fluid	NN	NN	_	9	conj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	joints	joint	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	5	cc	_	_
16	autoreactive	autoreactive	JJ	JJ	_	18	amod	_	_
17	T	t	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	21	nsubj	_	_
19	are	be	VBP	VBP	_	21	cop	_	_
20	readily	readily	RB	RB	_	21	advmod	_	_
21	demonstrable	demonstrable	JJ	JJ	_	5	conj	_	_
22	in	in	IN	IN	_	26	case	_	_
23	both	both	CC	CC	_	26	cc:preconj	_	_
24	the	the	DT	DT	_	26	dep	_	_
25	synovial	synovial	JJ	JJ	_	26	amod	_	_
26	compartment	compartment	NN	NN	_	21	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	blood	blood	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	5	punct	_	_

1	Circulating	circulate	VBG	VBG	_	3	amod	_	_
2	dendritic	dendritic	JJ	JJ	_	3	amod	_	_
3	cells	cell	NNS	NNS	_	11	nsubj	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	DC	dc	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	are	be	VBP	VBP	_	11	cop	_	_
8	phenotypically	phenotypically	RB	RB	_	9	advmod	_	_
9	and	and	CC	CC	_	11	advmod	_	_
10	functionally	functionally	RB	RB	_	9	advmod	_	_
11	identical	identical	JJ	JJ	_	0	root	_	_
12	with	with	IN	IN	_	19	case	_	_
13	normal	normal	JJ	JJ	_	19	amod	_	_
14	peripheral	peripheral	JJ	JJ	_	19	amod	_	_
15	blood	blood	NN	NN	_	19	compound	_	_
16	(	(	-LRB-	-LRB-	_	19	punct	_	_
17	PB	pb	NN	NN	_	19	compound	_	_
18	)	)	-RRB-	-RRB-	_	19	punct	_	_
19	DC	dc	NN	NN	_	11	nmod	_	_
20	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	synovial	synovial	JJ	JJ	_	4	amod	_	_
4	tissue	tissue	NN	NN	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	fully	fully	RB	RB	_	7	advmod	_	_
7	differentiated	differentiate	VBN	VBN	_	9	amod	_	_
8	perivascular	perivascular	JJ	JJ	_	9	amod	_	_
9	DC	dc	NN	NN	_	11	nsubjpass	_	_
10	are	be	VBP	VBP	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	0	root	_	_
12	in	in	IN	IN	_	14	case	_	_
13	close	close	JJ	JJ	_	14	amod	_	_
14	association	association	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	17	case	_	_
16	T	t	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	with	with	IN	IN	_	22	case	_	_
20	B	b	NN	NN	_	22	compound	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	follicles	follicle	NNS	NNS	_	17	conj	_	_
23	,	,	,	,	_	22	punct	_	_
24	sometimes	sometimes	RB	RB	_	25	advmod	_	_
25	containing	contain	VBG	VBG	_	22	acl	_	_
26	follicular	follicular	JJ	JJ	_	27	amod	_	_
27	DC	dc	NN	NN	_	25	dobj	_	_
28	.	.	.	.	_	11	punct	_	_

1	These	these	DT	DT	_	3	det	_	_
2	perivascular	perivascular	JJ	JJ	_	3	amod	_	_
3	DC	dc	NN	NN	_	4	nsubj	_	_
4	migrate	migrate	VBP	VBP	_	0	root	_	_
5	across	across	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	activated	activate	VBN	VBN	_	8	amod	_	_
8	endothelium	endothelium	NN	NN	_	4	nmod	_	_
9	from	from	IN	IN	_	10	case	_	_
10	blood	blood	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	4	cc	_	_
12	receive	receive	VBP	VBP	_	4	conj	_	_
13	differentiative	differentiative	JJ	JJ	_	14	amod	_	_
14	signals	signal	NNS	NNS	_	12	dobj	_	_
15	within	within	IN	IN	_	17	case	_	_
16	the	the	DT	DT	_	17	det	_	_
17	joint	joint	NN	NN	_	12	nmod	_	_
18	from	from	IN	IN	_	20	case	_	_
19	monocyte-derived	monocyte-derived	JJ	JJ	_	20	amod	_	_
20	cytokines	cytokine	NNS	NNS	_	12	nmod	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	CD40-ligand+	cd40-ligand+	JJ	JJ	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	20	conj	_	_
25	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	the	the	DT	DT	_	3	det	_	_
3	SF	sf	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	DC	dc	NN	NN	_	6	nsubj	_	_
6	manifest	manifest	VBP	VBP	_	0	root	_	_
7	an	a	DT	DT	_	9	det	_	_
8	intermediate	intermediate	JJ	JJ	_	9	amod	_	_
9	phenotype	phenotype	NN	NN	_	6	dobj	_	_
10	,	,	,	,	_	9	punct	_	_
11	similar	similar	JJ	JJ	_	9	amod	_	_
12	to	to	TO	TO	_	13	case	_	_
13	that	that	DT	DT	_	11	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	monocyte-derived	monocyte-derived	JJ	JJ	_	16	amod	_	_
16	DC	dc	NN	NN	_	13	nmod	_	_
17	in	in	FW	FW	_	16	amod	_	_
18	vitro	vitro	FW	FW	_	17	dep	_	_
19	.	.	.	.	_	6	punct	_	_

1	Like	like	IN	IN	_	5	case	_	_
2	a	a	DT	DT	_	5	det	_	_
3	delayed-type	delayed-type	JJ	JJ	_	5	amod	_	_
4	hypersensitivity	hypersensitivity	NN	NN	_	5	compound	_	_
5	response	response	NN	NN	_	10	nmod	_	_
6	,	,	,	,	_	10	punct	_	_
7	the	the	DT	DT	_	9	det	_	_
8	rheumatoid	rheumatoid	JJ	JJ	_	9	amod	_	_
9	synovium	synovium	NN	NN	_	10	nsubj	_	_
10	represents	represent	VBZ	VBZ	_	0	root	_	_
11	an	a	DT	DT	_	13	det	_	_
12	effector	effector	NN	NN	_	13	compound	_	_
13	site	site	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	10	punct	_	_

1	DC	dc	NN	NN	_	6	nsubj	_	_
2	at	at	IN	IN	_	5	case	_	_
3	many	many	JJ	JJ	_	5	amod	_	_
4	effector	effector	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	1	nmod	_	_
6	have	have	VBP	VBP	_	0	root	_	_
7	a	a	DT	DT	_	9	det	_	_
8	characteristic	characteristic	JJ	JJ	_	9	amod	_	_
9	pattern	pattern	NN	NN	_	6	dobj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	infiltration	infiltration	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	differentiation	differentiation	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	6	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	important	important	JJ	JJ	_	0	root	_	_
4	to	to	TO	TO	_	5	mark	_	_
5	note	note	VB	VB	_	3	xcomp	_	_
6	that	that	IN	IN	_	12	mark	_	_
7	the	the	DT	DT	_	9	det	_	_
8	effector	effector	NN	NN	_	9	compound	_	_
9	response	response	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	self-limiting	self-limiting	JJ	JJ	_	5	ccomp	_	_
13	in	in	IN	IN	_	16	case	_	_
14	RA	ra	NN	NN	_	16	compound	_	_
15	autoimmune	autoimmune	JJ	JJ	_	16	amod	_	_
16	inflammation	inflammation	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	article	article	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	argue	argue	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	20	mark	_	_
8	the	the	DT	DT	_	9	det	_	_
9	presentation	presentation	NN	NN	_	20	nsubj	_	_
10	of	of	IN	IN	_	11	case	_	_
11	self-antigen	self-antigen	NN	NN	_	9	nmod	_	_
12	by	by	IN	IN	_	13	case	_	_
13	DC	dc	NN	NN	_	9	nmod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	by	by	IN	IN	_	18	case	_	_
16	autoantibody-producing	autoantibody-producing	JJ	JJ	_	18	amod	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	13	conj	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	critical	critical	JJ	JJ	_	6	ccomp	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	perpetuation	perpetuation	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	autoimmune	autoimmune	JJ	JJ	_	27	amod	_	_
27	response	response	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Permanently	permanently	RB	RB	_	6	advmod	_	_
2	arresting	arrest	VBG	VBG	_	6	amod	_	_
3	this	this	DT	DT	_	6	det	_	_
4	ongoing	ongoing	JJ	JJ	_	6	amod	_	_
5	immune	immune	JJ	JJ	_	6	amod	_	_
6	response	response	NN	NN	_	16	nsubj	_	_
7	with	with	IN	IN	_	10	case	_	_
8	either	either	CC	CC	_	10	cc:preconj	_	_
9	pharmaceutical	pharmaceutical	JJ	JJ	_	10	amod	_	_
10	agents	agent	NNS	NNS	_	6	nmod	_	_
11	or	or	CC	CC	_	10	cc	_	_
12	immunotherapy	immunotherapy	NN	NN	_	10	conj	_	_
13	is	be	VBZ	VBZ	_	16	cop	_	_
14	a	a	DT	DT	_	16	det	_	_
15	major	major	JJ	JJ	_	16	amod	_	_
16	challenge	challenge	NN	NN	_	0	root	_	_
17	for	for	IN	IN	_	18	case	_	_
18	immunology	immunology	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	16	punct	_	_

1	Estrogen	estrogen	NN	NN	_	2	nsubj	_	_
2	decreases	decrease	VBZ	VBZ	_	0	root	_	_
3	TNF	tnf	NN	NN	_	5	compound	_	_
4	gene	gene	NN	NN	_	5	compound	_	_
5	expression	expression	NN	NN	_	2	dobj	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	blocking	block	VBG	VBG	_	2	advcl	_	_
8	JNK	jnk	NN	NN	_	9	compound	_	_
9	activity	activity	NN	NN	_	7	dobj	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	the	the	DT	DT	_	13	det	_	_
12	resulting	result	VBG	VBG	_	13	amod	_	_
13	production	production	NN	NN	_	9	conj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	c-Jun	c-jun	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	JunD	jund	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	Central	central	JJ	JJ	_	16	nsubj	_	_
2	to	to	TO	TO	_	5	case	_	_
3	the	the	DT	DT	_	5	det	_	_
4	bone-sparing	bone-sparing	JJ	JJ	_	5	amod	_	_
5	effect	effect	NN	NN	_	1	nmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	estrogen	estrogen	NN	NN	_	5	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	E	e	NN	NN	_	7	appos	_	_
10	(	(	-LRB-	-LRB-	_	9	punct	_	_
11	2	2	CD	CD	_	9	nummod	_	_
12	)	)	-RRB-	-RRB-	_	9	punct	_	_
13	)	)	-RRB-	-RRB-	_	9	punct	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	its	its	PRP$	PRP$	_	16	nmod:poss	_	_
16	ability	ability	NN	NN	_	0	root	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	block	block	VB	VB	_	16	acl	_	_
19	the	the	DT	DT	_	21	det	_	_
20	monocytic	monocytic	JJ	JJ	_	21	amod	_	_
21	production	production	NN	NN	_	18	dobj	_	_
22	of	of	IN	IN	_	26	case	_	_
23	the	the	DT	DT	_	26	det	_	_
24	osteoclastogenic	osteoclastogenic	JJ	JJ	_	26	amod	_	_
25	cytokine	cytokine	NN	NN	_	26	compound	_	_
26	TNF-alpha	tnf-alpha	NN	NN	_	21	nmod	_	_
27	(	(	-LRB-	-LRB-	_	28	punct	_	_
28	TNF	tnf	NN	NN	_	26	appos	_	_
29	)	)	-RRB-	-RRB-	_	28	punct	_	_
30	.	.	.	.	_	16	punct	_	_

1	However	however	RB	RB	_	16	advmod	_	_
2	,	,	,	,	_	16	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	16	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	11	nmod	_	_
7	E	e	NN	NN	_	11	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	7	punct	_	_
9	2	2	CD	CD	_	7	nummod	_	_
10	)	)	-RRB-	-RRB-	_	7	punct	_	_
11	downregulates	downregulate	VBZ	VBZ	_	4	acl:relcl	_	_
12	TNF	tnf	NN	NN	_	13	compound	_	_
13	production	production	NN	NN	_	11	dobj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	presently	presently	RB	RB	_	16	advmod	_	_
16	unknown	unknown	JJ	JJ	_	0	root	_	_
17	.	.	.	.	_	16	punct	_	_

1	Transient	transient	JJ	JJ	_	3	amod	_	_
2	transfection	transfection	NN	NN	_	3	compound	_	_
3	studies	study	NNS	NNS	_	16	nsubj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	HeLa	hela	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	3	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	an	a	DT	DT	_	14	det	_	_
9	E	e	NN	NN	_	14	compound	_	_
10	(	(	-LRB-	-LRB-	_	14	punct	_	_
11	2	2	CD	CD	_	14	nummod	_	_
12	)	)	-RRB-	-RRB-	_	14	punct	_	_
13	receptor-negative	receptor-negative	JJ	JJ	_	14	amod	_	_
14	line	line	NN	NN	_	6	appos	_	_
15	,	,	,	,	_	3	punct	_	_
16	suggest	suggest	VBP	VBP	_	0	root	_	_
17	that	that	IN	IN	_	22	mark	_	_
18	E	e	NN	NN	_	22	nsubj	_	_
19	(	(	-LRB-	-LRB-	_	18	punct	_	_
20	2	2	CD	CD	_	18	nummod	_	_
21	)	)	-RRB-	-RRB-	_	18	punct	_	_
22	inhibits	inhibit	VBZ	VBZ	_	16	ccomp	_	_
23	TNF	tnf	NN	NN	_	25	compound	_	_
24	gene	gene	NN	NN	_	25	compound	_	_
25	expression	expression	NN	NN	_	22	dobj	_	_
26	through	through	IN	IN	_	28	case	_	_
27	an	a	DT	DT	_	28	det	_	_
28	effect	effect	NN	NN	_	22	nmod	_	_
29	mediated	mediate	VBN	VBN	_	28	acl	_	_
30	by	by	IN	IN	_	33	case	_	_
31	estrogen	estrogen	NN	NN	_	33	compound	_	_
32	receptor	receptor	NN	NN	_	33	compound	_	_
33	beta	beta	NN	NN	_	29	nmod	_	_
34	(	(	-LRB-	-LRB-	_	35	punct	_	_
35	ERbeta	erbeta	NN	NN	_	33	appos	_	_
36	)	)	-RRB-	-RRB-	_	35	punct	_	_
37	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	report	report	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	24	mark	_	_
5	in	in	IN	IN	_	8	case	_	_
6	RAW	raw	NN	NN	_	8	compound	_	_
7	264.7	264.7	CD	CD	_	8	nummod	_	_
8	cells	cell	NNS	NNS	_	24	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	an	a	DT	DT	_	18	det	_	_
11	E	e	NN	NN	_	18	compound	_	_
12	(	(	-LRB-	-LRB-	_	18	punct	_	_
13	2	2	CD	CD	_	18	nummod	_	_
14	)	)	-RRB-	-RRB-	_	18	punct	_	_
15	receptor-positive	receptor-positive	JJ	JJ	_	18	amod	_	_
16	murine	murine	JJ	JJ	_	18	amod	_	_
17	monocytic	monocytic	JJ	JJ	_	18	amod	_	_
18	line	line	NN	NN	_	8	appos	_	_
19	,	,	,	,	_	8	punct	_	_
20	E	e	NN	NN	_	24	nsubj	_	_
21	(	(	-LRB-	-LRB-	_	20	punct	_	_
22	2	2	CD	CD	_	20	nummod	_	_
23	)	)	-RRB-	-RRB-	_	20	punct	_	_
24	downregulates	downregulate	VBZ	VBZ	_	3	ccomp	_	_
25	cytokine-induced	cytokine-induced	JJ	JJ	_	28	amod	_	_
26	TNF	tnf	NN	NN	_	28	compound	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	expression	expression	NN	NN	_	24	dobj	_	_
29	by	by	IN	IN	_	30	mark	_	_
30	decreasing	decrease	VBG	VBG	_	24	advcl	_	_
31	the	the	DT	DT	_	32	det	_	_
32	activity	activity	NN	NN	_	30	dobj	_	_
33	of	of	IN	IN	_	37	case	_	_
34	the	the	DT	DT	_	37	det	_	_
35	Jun	jun	NN	NN	_	37	compound	_	_
36	NH(2)-terminal	nh(2)-terminal	JJ	JJ	_	37	amod	_	_
37	kinase	kinase	NN	NN	_	32	nmod	_	_
38	(	(	-LRB-	-LRB-	_	39	punct	_	_
39	JNK	jnk	NN	NN	_	37	appos	_	_
40	)	)	-RRB-	-RRB-	_	39	punct	_	_
41	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	resulting	result	VBG	VBG	_	4	amod	_	_
3	diminished	diminish	VBN	VBN	_	4	amod	_	_
4	phosphorylation	phosphorylation	NN	NN	_	12	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	c-Jun	c-jun	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	JunD	jund	NN	NN	_	6	conj	_	_
9	at	at	IN	IN	_	11	case	_	_
10	their	they	PRP$	PRP$	_	11	nmod:poss	_	_
11	NH(2)-termini	nh(2)-terminus	NNS	NNS	_	4	nmod	_	_
12	decreases	decrease	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	these	these	DT	DT	_	18	det	_	_
17	nuclear	nuclear	JJ	JJ	_	18	amod	_	_
18	proteins	protein	NNS	NNS	_	14	nmod	_	_
19	to	to	TO	TO	_	20	mark	_	_
20	autostimulate	autostimulate	VB	VB	_	14	acl	_	_
21	the	the	DT	DT	_	22	det	_	_
22	expression	expression	NN	NN	_	20	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	the	the	DT	DT	_	25	dep	_	_
25	c-Jun	c-jun	NN	NN	_	22	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	JunD	jund	NN	NN	_	25	conj	_	_
28	genes	gene	NNS	NNS	_	25	dep	_	_
29	,	,	,	,	_	12	punct	_	_
30	thus	thus	RB	RB	_	31	advmod	_	_
31	leading	lead	VBG	VBG	_	12	advcl	_	_
32	to	to	TO	TO	_	34	case	_	_
33	lower	lower	JJR	JJR	_	34	amod	_	_
34	production	production	NN	NN	_	31	nmod	_	_
35	of	of	IN	IN	_	36	case	_	_
36	c-Jun	c-jun	NN	NN	_	34	nmod	_	_
37	and	and	CC	CC	_	36	cc	_	_
38	JunD	jund	NN	NN	_	36	conj	_	_
39	.	.	.	.	_	12	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	consequent	consequent	JJ	JJ	_	3	amod	_	_
3	decrease	decrease	NN	NN	_	12	nsubj	_	_
4	in	in	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	levels	level	NNS	NNS	_	3	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	c-Jun	c-jun	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	JunD	jund	NN	NN	_	9	conj	_	_
12	leads	lead	VBZ	VBZ	_	0	root	_	_
13	to	to	TO	TO	_	15	case	_	_
14	diminished	diminish	VBN	VBN	_	15	amod	_	_
15	binding	binding	NN	NN	_	32	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	c-Jun/c-Fos	c-jun/c-fos	NN	NN	_	15	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	JunD/c-Fos	jund/c-fos	NN	NN	_	20	compound	_	_
20	heterodimers	heterodimer	NNS	NNS	_	17	conj	_	_
21	to	to	TO	TO	_	25	case	_	_
22	the	the	DT	DT	_	25	det	_	_
23	AP-1	ap-1	NN	NN	_	25	compound	_	_
24	consensus	consensus	NN	NN	_	25	compound	_	_
25	sequence	sequence	NN	NN	_	15	nmod	_	_
26	in	in	IN	IN	_	29	case	_	_
27	the	the	DT	DT	_	29	det	_	_
28	TNF	tnf	NN	NN	_	29	compound	_	_
29	promoter	promoter	NN	NN	_	15	nmod	_	_
30	and	and	CC	CC	_	32	cc	_	_
31	,	,	,	,	_	32	punct	_	_
32	thus	thus	RB	RB	_	12	nmod	_	_
33	,	,	,	,	_	32	punct	_	_
34	to	to	TO	TO	_	36	case	_	_
35	decreased	decrease	VBN	VBN	_	36	amod	_	_
36	transactivation	transactivation	NN	NN	_	32	conj	_	_
37	of	of	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	TNF	tnf	NN	NN	_	40	compound	_	_
40	gene	gene	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	12	punct	_	_

1	TCL1	tcl1	NN	NN	_	3	compound	_	_
2	oncogene	oncogene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	0	root	_	_
4	in	in	IN	IN	_	6	case	_	_
5	AIDS-related	aids-related	JJ	JJ	_	6	amod	_	_
6	lymphomas	lymphoma	NNS	NNS	_	3	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	lymphoid	lymphoid	JJ	JJ	_	9	amod	_	_
9	tissues	tissue	NNS	NNS	_	6	conj	_	_
10	.	.	.	.	_	3	punct	_	_

1	AIDS-related	aids-related	JJ	JJ	_	4	amod	_	_
2	non-Hodgkin	non-hodgkin	JJ	JJ	_	4	amod	_	_
3	's	's	POS	POS	_	4	case	_	_
4	lymphoma	lymphoma	NN	NN	_	9	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	7	punct	_	_
6	AIDS	aids	NN	NN	_	7	compound	_	_
7	NHL	nhl	NN	NN	_	4	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	comprises	comprise	VBZ	VBZ	_	0	root	_	_
10	a	a	DT	DT	_	14	det	_	_
11	diverse	diverse	JJ	JJ	_	14	amod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	heterogeneous	heterogeneous	JJ	JJ	_	11	conj	_	_
14	group	group	NN	NN	_	9	dobj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	high-grade	high-grade	JJ	JJ	_	19	amod	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	tumors	tumor	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	9	punct	_	_

1	Certain	certain	JJ	JJ	_	2	amod	_	_
2	classes	class	NNS	NNS	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	AIDS	aids	NN	NN	_	5	compound	_	_
5	NHL	nhl	NN	NN	_	2	nmod	_	_
6	are	be	VBP	VBP	_	7	auxpass	_	_
7	associated	associate	VBN	VBN	_	0	root	_	_
8	with	with	IN	IN	_	9	case	_	_
9	alterations	alteration	NNS	NNS	_	7	nmod	_	_
10	in	in	IN	IN	_	11	case	_	_
11	oncogenes	oncogene	NNS	NNS	_	9	nmod	_	_
12	or	or	CC	CC	_	11	cc	_	_
13	tumor-suppressor	tumor-suppressor	JJ	JJ	_	14	amod	_	_
14	genes	gene	NNS	NNS	_	11	conj	_	_
15	or	or	CC	CC	_	9	cc	_	_
16	infections	infection	NNS	NNS	_	9	conj	_	_
17	by	by	IN	IN	_	19	case	_	_
18	oncogenic	oncogenic	JJ	JJ	_	19	amod	_	_
19	herpesviruses	herpesvirus	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	18	advmod	_	_
2	,	,	,	,	_	18	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	clinically	clinically	RB	RB	_	6	advmod	_	_
5	significant	significant	JJ	JJ	_	6	amod	_	_
6	class	class	NN	NN	_	18	nsubj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	AIDS	aids	NN	NN	_	9	compound	_	_
9	NHL	nhl	NN	NN	_	6	nmod	_	_
10	designated	designated	JJ	JJ	_	6	dep	_	_
11	immunoblastic	immunoblastic	JJ	JJ	_	13	amod	_	_
12	lymphoma	lymphoma	NN	NN	_	13	compound	_	_
13	plasmacytoid	plasmacytoid	NN	NN	_	10	xcomp	_	_
14	(	(	-LRB-	-LRB-	_	16	punct	_	_
15	AIDS	aids	NN	NN	_	16	compound	_	_
16	IBLP	iblp	NN	NN	_	13	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	lacks	lack	VBZ	VBZ	_	0	root	_	_
19	any	any	DT	DT	_	22	det	_	_
20	consistent	consistent	JJ	JJ	_	22	amod	_	_
21	genetic	genetic	JJ	JJ	_	22	amod	_	_
22	alterations	alteration	NNS	NNS	_	18	dobj	_	_
23	.	.	.	.	_	18	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	identified	identify	VBD	VBD	_	0	root	_	_
3	the	the	DT	DT	_	5	det	_	_
4	TCL1	tcl1	NN	NN	_	5	compound	_	_
5	oncogene	oncogene	NN	NN	_	2	dobj	_	_
6	from	from	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	set	set	NN	NN	_	2	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	AIDS	aids	NN	NN	_	13	compound	_	_
11	IBLP-associated	iblp-associated	JJ	JJ	_	13	amod	_	_
12	cDNA	cdna	NN	NN	_	13	compound	_	_
13	fragments	fragment	NNS	NNS	_	8	nmod	_	_
14	generated	generate	VBN	VBN	_	13	acl	_	_
15	by	by	IN	IN	_	17	case	_	_
16	subtractive	subtractive	JJ	JJ	_	17	amod	_	_
17	hybridization	hybridization	NN	NN	_	14	nmod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	non-AIDS	non-aids	JJ	JJ	_	20	amod	_	_
20	IBLP	iblp	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	2	punct	_	_

1	Aberrant	aberrant	JJ	JJ	_	3	amod	_	_
2	TCL1	tcl1	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	6	nsubjpass	_	_
4	has	have	VBZ	VBZ	_	6	aux	_	_
5	been	be	VBN	VBN	_	6	auxpass	_	_
6	implicated	implicate	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	11	case	_	_
8	T	t	NN	NN	_	11	compound	_	_
9	cell	cell	NN	NN	_	11	compound	_	_
10	leukemia/lymphoma	leukemia/lymphoma	JJ	JJ	_	11	amod	_	_
11	development	development	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	6	punct	_	_
13	and	and	CC	CC	_	6	cc	_	_
14	its	its	PRP$	PRP$	_	15	nmod:poss	_	_
15	expression	expression	NN	NN	_	19	nsubjpass	_	_
16	also	also	RB	RB	_	19	advmod	_	_
17	has	have	VBZ	VBZ	_	19	aux	_	_
18	been	be	VBN	VBN	_	19	auxpass	_	_
19	seen	see	VBN	VBN	_	6	conj	_	_
20	in	in	IN	IN	_	26	case	_	_
21	many	many	JJ	JJ	_	26	amod	_	_
22	established	established	JJ	JJ	_	26	amod	_	_
23	B	b	NN	NN	_	26	compound	_	_
24	cell	cell	NN	NN	_	26	compound	_	_
25	tumor	tumor	NN	NN	_	26	compound	_	_
26	lines	line	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	TCL1	tcl1	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	8	nsubjpass	_	_
5	has	have	VBZ	VBZ	_	8	aux	_	_
6	not	not	RB	RB	_	8	neg	_	_
7	been	be	VBN	VBN	_	8	auxpass	_	_
8	reported	report	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	AIDS	aids	NN	NN	_	11	compound	_	_
11	NHL	nhl	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	8	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	6	mark	_	_
4	TCL1	tcl1	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	expressed	express	VBN	VBN	_	2	ccomp	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	majority	majority	NN	NN	_	6	nmod	_	_
10	of	of	IN	IN	_	13	case	_	_
11	AIDS	aids	NN	NN	_	13	compound	_	_
12	IBLP	iblp	NN	NN	_	13	compound	_	_
13	tumors	tumor	NNS	NNS	_	9	nmod	_	_
14	examined	examine	VBN	VBN	_	13	acl	_	_
15	.	.	.	.	_	2	punct	_	_

1	TCL1	tcl1	NN	NN	_	3	compound	_	_
2	protein	protein	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	restricted	restricted	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	tumor	tumor	NN	NN	_	8	compound	_	_
8	cells	cell	NNS	NNS	_	5	nmod	_	_
9	in	in	IN	IN	_	13	case	_	_
10	AIDS	aids	NN	NN	_	13	compound	_	_
11	IBLP	iblp	NN	NN	_	13	compound	_	_
12	tissue	tissue	NN	NN	_	13	compound	_	_
13	samples	sample	NNS	NNS	_	8	nmod	_	_
14	analyzed	analyze	VBN	VBN	_	13	acl	_	_
15	with	with	IN	IN	_	17	case	_	_
16	immunohistochemical	immunohistochemical	JJ	JJ	_	17	amod	_	_
17	staining	staining	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Hyperplastic	hyperplastic	JJ	JJ	_	3	amod	_	_
2	lymph	lymph	NN	NN	_	3	compound	_	_
3	node	node	NN	NN	_	7	nsubj	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	tonsil	tonsil	NN	NN	_	3	conj	_	_
6	also	also	RB	RB	_	7	advmod	_	_
7	exhibit	exhibit	VBP	VBP	_	0	root	_	_
8	strong	strong	JJ	JJ	_	11	amod	_	_
9	TCL1	tcl1	NN	NN	_	11	compound	_	_
10	protein	protein	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	7	dobj	_	_
12	in	in	IN	IN	_	16	case	_	_
13	mantle	mantle	NN	NN	_	16	compound	_	_
14	zone	zone	NN	NN	_	16	compound	_	_
15	B	b	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	7	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	in	in	IN	IN	_	22	case	_	_
19	rare	rare	JJ	JJ	_	22	amod	_	_
20	interfollicular	interfollicular	JJ	JJ	_	22	amod	_	_
21	zone	zone	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	16	conj	_	_
23	,	,	,	,	_	7	punct	_	_
24	whereas	whereas	IN	IN	_	7	dep	_	_
25	follicle-center	follicle-center	JJ	JJ	_	27	amod	_	_
26	B	b	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	33	nsubj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	centroblasts	centroblast	NNS	NNS	_	27	dep	_	_
30	and	and	CC	CC	_	29	cc	_	_
31	centrocytes	centrocyte	NNS	NNS	_	29	conj	_	_
32	)	)	-RRB-	-RRB-	_	29	punct	_	_
33	show	show	VBP	VBP	_	7	parataxis	_	_
34	weaker	weaker	JJR	JJR	_	35	amod	_	_
35	expression	expression	NN	NN	_	33	dobj	_	_
36	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	establish	establish	VBP	VBP	_	0	root	_	_
4	TCL1	tcl1	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	most	most	RBS	RBS	_	8	advmod	_	_
8	prevalent	prevalent	JJ	JJ	_	3	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	all	all	DT	DT	_	8	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	surveyed	survey	VBN	VBN	_	14	amod	_	_
14	oncogenes	oncogene	NNS	NNS	_	10	nmod	_	_
15	associated	associate	VBN	VBN	_	14	acl	_	_
16	with	with	IN	IN	_	18	case	_	_
17	AIDS	aids	NN	NN	_	18	compound	_	_
18	IBLP	iblp	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	They	they	PRP	PRP	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	15	mark	_	_
5	abundant	abundant	JJ	JJ	_	7	amod	_	_
6	TCL1	tcl1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	15	nsubjpass	_	_
8	in	in	IN	IN	_	13	case	_	_
9	quiescent	quiescent	JJ	JJ	_	13	amod	_	_
10	mantle	mantle	NN	NN	_	13	compound	_	_
11	zone	zone	NN	NN	_	13	compound	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	down-regulated	down-regulate	VBN	VBN	_	3	ccomp	_	_
16	in	in	IN	IN	_	22	case	_	_
17	activated	activate	VBN	VBN	_	22	amod	_	_
18	germinal	germinal	JJ	JJ	_	22	amod	_	_
19	center	center	NN	NN	_	22	compound	_	_
20	follicular	follicular	JJ	JJ	_	22	amod	_	_
21	B	b	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	15	nmod	_	_
23	in	in	IN	IN	_	24	case	_	_
24	parallel	parallel	NN	NN	_	15	nmod	_	_
25	to	to	TO	TO	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	known	known	JJ	JJ	_	29	amod	_	_
28	expression	expression	NN	NN	_	29	compound	_	_
29	pattern	pattern	NN	NN	_	24	nmod	_	_
30	of	of	IN	IN	_	31	case	_	_
31	BCL-2	bcl-2	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	3	punct	_	_

1	High-level	high-level	JJ	JJ	_	2	amod	_	_
2	expression	expression	NN	NN	_	7	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	nonproliferating	nonproliferating	JJ	JJ	_	6	amod	_	_
5	B	b	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	suggests	suggest	VBZ	VBZ	_	0	root	_	_
8	that	that	IN	IN	_	11	mark	_	_
9	TCL1	tcl1	NN	NN	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	function	function	VB	VB	_	7	ccomp	_	_
12	in	in	IN	IN	_	13	mark	_	_
13	protecting	protect	VBG	VBG	_	11	advcl	_	_
14	naive	naive	JJ	JJ	_	17	amod	_	_
15	preactivated	preactivated	JJ	JJ	_	17	amod	_	_
16	B	b	NN	NN	_	17	compound	_	_
17	cells	cell	NNS	NNS	_	13	dobj	_	_
18	from	from	IN	IN	_	19	case	_	_
19	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
20	.	.	.	.	_	7	punct	_	_

1	Signal	signal	NN	NN	_	3	compound	_	_
2	transduction	transduction	NN	NN	_	3	compound	_	_
3	pathways	pathway	NNS	NNS	_	15	nsubj	_	_
4	triggered	trigger	VBN	VBN	_	3	acl	_	_
5	by	by	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	FcepsilonRIIb	fcepsilonriib	NN	NN	_	8	compound	_	_
8	receptor	receptor	NN	NN	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	CD23	cd23	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	4	nmod	_	_
15	lead	lead	VBP	VBP	_	0	root	_	_
16	to	to	TO	TO	_	19	case	_	_
17	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
18	factor-kappaB	factor-kappab	NN	NN	_	19	compound	_	_
19	activation	activation	NN	NN	_	15	nmod	_	_
20	.	.	.	.	_	15	punct	_	_

1	BACKGROUND	background	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Alveolar	alveolar	JJ	JJ	_	4	amod	_	_
4	macrophages	macrophage	NNS	NNS	_	5	nsubj	_	_
5	play	play	VBP	VBP	_	1	dep	_	_
6	a	a	DT	DT	_	8	det	_	_
7	key	key	JJ	JJ	_	8	amod	_	_
8	role	role	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	the	the	DT	DT	_	11	det	_	_
11	initiation	initiation	NN	NN	_	5	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	inflammatory	inflammatory	JJ	JJ	_	15	amod	_	_
15	reaction	reaction	NN	NN	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	allergic	allergic	JJ	JJ	_	18	amod	_	_
18	asthma	asthma	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Alveolar	alveolar	JJ	JJ	_	2	amod	_	_
2	macrophages	macrophage	NNS	NNS	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	peripheral	peripheral	JJ	JJ	_	6	amod	_	_
5	blood	blood	NN	NN	_	6	compound	_	_
6	monocytes	monocyte	NNS	NNS	_	2	conj	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	activated	activate	VBN	VBN	_	0	root	_	_
9	when	when	WRB	WRB	_	13	advmod	_	_
10	IgE/allergen	ige/allergen	JJ	JJ	_	12	amod	_	_
11	immune	immune	JJ	JJ	_	12	amod	_	_
12	complexes	complex	NNS	NNS	_	13	nsubj	_	_
13	bind	bind	VBP	VBP	_	8	ccomp	_	_
14	to	to	TO	TO	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	CD23	cd23	NN	NN	_	17	compound	_	_
17	receptor	receptor	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	17	punct	_	_
19	which	which	WDT	WDT	_	20	nsubj	_	_
20	leads	lead	VBZ	VBZ	_	17	acl:relcl	_	_
21	to	to	TO	TO	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	production	production	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	26	case	_	_
25	inflammatory	inflammatory	JJ	JJ	_	26	amod	_	_
26	cytokines	cytokine	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	OBJECTIVE	objective	NN	NN	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	We	we	PRP	PRP	_	4	nsubj	_	_
4	sought	seek	VBD	VBD	_	1	dep	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	investigate	investigate	VB	VB	_	4	xcomp	_	_
7	the	the	DT	DT	_	9	det	_	_
8	molecular	molecular	JJ	JJ	_	9	amod	_	_
9	mechanisms	mechanism	NNS	NNS	_	6	dobj	_	_
10	regulating	regulate	VBG	VBG	_	9	acl	_	_
11	this	this	DT	DT	_	14	det	_	_
12	early	early	JJ	JJ	_	14	amod	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	response	response	NN	NN	_	10	dobj	_	_
15	.	.	.	.	_	1	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	focused	focus	VBN	VBN	_	0	root	_	_
4	on	on	IN	IN	_	6	case	_	_
5	the	the	DT	DT	_	6	det	_	_
6	study	study	NN	NN	_	3	nmod	_	_
7	of	of	IN	IN	_	11	case	_	_
8	the	the	DT	DT	_	11	det	_	_
9	signal	signal	NN	NN	_	11	compound	_	_
10	transduction	transduction	NN	NN	_	11	compound	_	_
11	pathways	pathway	NNS	NNS	_	6	nmod	_	_
12	triggered	trigger	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	CD23	cd23	NN	NN	_	12	nmod	_	_
15	in	in	IN	IN	_	17	case	_	_
16	human	human	JJ	JJ	_	17	amod	_	_
17	monocytes	monocyte	NNS	NNS	_	12	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	the	the	DT	DT	_	23	det	_	_
20	promonocytic	promonocytic	JJ	JJ	_	23	amod	_	_
21	cell	cell	NN	NN	_	23	compound	_	_
22	line	line	NN	NN	_	23	compound	_	_
23	U937	u937	NN	NN	_	17	conj	_	_
24	.	.	.	.	_	3	punct	_	_

1	METHODS	method	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	CD23	cd23	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	cross-linked	cross-link	VBN	VBN	_	1	dep	_	_
6	in	in	IN	IN	_	8	case	_	_
7	human	human	JJ	JJ	_	8	amod	_	_
8	monocytes	monocyte	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	U937	u937	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	conj	_	_
12	with	with	IN	IN	_	15	case	_	_
13	IgE	ige	NN	NN	_	15	compound	_	_
14	immune	immune	JJ	JJ	_	15	amod	_	_
15	complexes	complex	NNS	NNS	_	5	nmod	_	_
16	.	.	.	.	_	1	punct	_	_

1	Surface	surface	NN	NN	_	2	compound	_	_
2	expression	expression	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	CD23	cd23	NN	NN	_	2	nmod	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	determined	determine	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	FACS	facs	NN	NN	_	9	compound	_	_
9	analysis	analysis	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Transcription	transcription	NN	NN	_	3	compound	_	_
2	factor	factor	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	8	nsubjpass	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	gene	gene	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	3	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	studied	study	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	11	case	_	_
10	gel-shift	gel-shift	JJ	JJ	_	11	amod	_	_
11	assays	assay	NNS	NNS	_	8	nmod	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	Northern	northern	JJ	JJ	_	15	amod	_	_
14	blot	blot	NN	NN	_	15	compound	_	_
15	analysis	analysis	NN	NN	_	11	conj	_	_
16	,	,	,	,	_	8	punct	_	_
17	respectively	respectively	RB	RB	_	8	advmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	IkappaBalpha	ikappabalpha	NN	NN	_	6	nsubjpass	_	_
2	phosphorylation	phosphorylation	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	degradation	degradation	NN	NN	_	2	conj	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	analyzed	analyze	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	9	case	_	_
8	Western	western	JJ	JJ	_	9	amod	_	_
9	blot	blot	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	RESULTS	result	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	Nuclear	nuclear	JJ	JJ	_	8	amod	_	_
4	factor	factor	NN	NN	_	8	compound	_	_
5	(	(	-LRB-	-LRB-	_	8	punct	_	_
6	NF	nf	NN	NN	_	8	compound	_	_
7	)	)	-RRB-	-RRB-	_	8	punct	_	_
8	-kappaB	-kappab	NN	NN	_	13	nsubj	_	_
9	is	be	VBZ	VBZ	_	13	cop	_	_
10	the	the	DT	DT	_	13	det	_	_
11	main	main	JJ	JJ	_	13	amod	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factor	factor	NN	NN	_	1	dep	_	_
14	involved	involve	VBN	VBN	_	13	acl	_	_
15	in	in	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	that	that	WDT	WDT	_	20	nsubj	_	_
20	follows	follow	VBZ	VBZ	_	18	acl:relcl	_	_
21	CD23	cd23	NN	NN	_	22	compound	_	_
22	cross-linking	cross-linking	NN	NN	_	20	dobj	_	_
23	in	in	IN	IN	_	24	case	_	_
24	monocytes	monocyte	NNS	NNS	_	22	nmod	_	_
25	.	.	.	.	_	1	punct	_	_

1	CD23-induced	cd23-induced	JJ	JJ	_	2	amod	_	_
2	NF-kappaB	nf-kappab	NN	NN	_	5	nsubj	_	_
3	is	be	VBZ	VBZ	_	5	cop	_	_
4	a	a	DT	DT	_	5	det	_	_
5	heterodimer	heterodimer	NN	NN	_	0	root	_	_
6	composed	compose	VBN	VBN	_	5	amod	_	_
7	of	of	IN	IN	_	9	case	_	_
8	p65/p50	p65/p50	JJ	JJ	_	9	amod	_	_
9	subunits	subunit	NNS	NNS	_	5	nmod	_	_
10	.	.	.	.	_	5	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	3	compound	_	_
2	nuclear	nuclear	JJ	JJ	_	3	amod	_	_
3	translocation	translocation	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	secondary	secondary	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	dep	_	_
8	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	subsequent	subsequent	JJ	JJ	_	11	amod	_	_
11	degradation	degradation	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	NF-kappaB	nf-kappab	NN	NN	_	17	compound	_	_
15	inhibitory	inhibitory	JJ	JJ	_	17	amod	_	_
16	molecule	molecule	NN	NN	_	17	compound	_	_
17	IkappaBalpha	ikappabalpha	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	5	punct	_	_

1	Tyrosine	tyrosine	NN	NN	_	2	nmod:npmod	_	_
2	kinase-dependent	kinase-dependent	JJ	JJ	_	10	amod	_	_
3	,	,	,	,	_	2	punct	_	_
4	and	and	CC	CC	_	2	cc	_	_
5	not	not	RB	RB	_	2	conj	_	_
6	protein	protein	NN	NN	_	8	nmod:npmod	_	_
7	kinase	kinase	NN	NN	_	8	nmod:npmod	_	_
8	C-dependent	c-dependent	JJ	JJ	_	2	dep	_	_
9	,	,	,	,	_	2	punct	_	_
10	pathways	pathway	NNS	NNS	_	11	nsubj	_	_
11	mediate	mediate	VBP	VBP	_	0	root	_	_
12	CD23-triggered	cd23-triggered	JJ	JJ	_	14	amod	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	activation	activation	NN	NN	_	11	dobj	_	_
15	but	but	CC	CC	_	11	cc	_	_
16	do	do	VBP	VBP	_	18	aux	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	participate	participate	VB	VB	_	11	conj	_	_
19	in	in	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	direct	direct	JJ	JJ	_	22	amod	_	_
22	phosphorylation	phosphorylation	NN	NN	_	18	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	IkappaBalpha	ikappabalpha	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	IkappaBalpha	ikappabalpha	NN	NN	_	2	compound	_	_
2	degradation	degradation	NN	NN	_	7	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
5	nuclear	nuclear	JJ	JJ	_	6	amod	_	_
6	translocation	translocation	NN	NN	_	2	conj	_	_
7	correlate	correlate	VBP	VBP	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	transcriptional	transcriptional	JJ	JJ	_	10	amod	_	_
10	activation	activation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	cytokines	cytokine	NNS	NNS	_	10	nmod	_	_
15	TNF-alpha	tnf-alpha	NN	NN	_	14	dep	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	IL-1beta	il-1beta	NN	NN	_	15	conj	_	_
18	.	.	.	.	_	7	punct	_	_

1	CONCLUSIONS	conclusion	NNS	NNS	_	0	root	_	_
2	:	:	:	:	_	1	punct	_	_
3	NF-kappaB	nf-kappab	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	the	the	DT	DT	_	8	det	_	_
6	main	main	JJ	JJ	_	8	amod	_	_
7	transcription	transcription	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	1	dep	_	_
9	involved	involve	VBN	VBN	_	8	acl	_	_
10	in	in	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	signal	signal	NN	NN	_	14	compound	_	_
13	transduction	transduction	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	9	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	CD23	cd23	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	monocytes	monocyte	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	1	punct	_	_

1	Dopamine	dopamine	NN	NN	_	2	nsubj	_	_
2	stimulates	stimulate	VBZ	VBZ	_	0	root	_	_
3	expression	expression	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	the	the	DT	DT	_	9	det	_	_
6	human	human	JJ	JJ	_	9	amod	_	_
7	immunodeficiency	immunodeficiency	NN	NN	_	9	compound	_	_
8	virus	virus	NN	NN	_	9	compound	_	_
9	type	type	NN	NN	_	3	nmod	_	_
10	1	1	CD	CD	_	9	nummod	_	_
11	via	via	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	2	nmod	_	_
13	in	in	IN	IN	_	14	case	_	_
14	cells	cell	NNS	NNS	_	2	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	system	system	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	2	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	reported	report	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	7	mark	_	_
6	lymphocytes	lymphocyte	NNS	NNS	_	7	nsubj	_	_
7	produce	produce	VBP	VBP	_	4	ccomp	_	_
8	,	,	,	,	_	7	punct	_	_
9	transport	transport	VBP	VBP	_	7	conj	_	_
10	and	and	CC	CC	_	7	cc	_	_
11	bind	bind	VBP	VBP	_	7	conj	_	_
12	dopamine	dopamine	NN	NN	_	7	dobj	_	_
13	present	present	JJ	JJ	_	12	amod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	plasma	plasma	NN	NN	_	13	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	However	however	RB	RB	_	21	advmod	_	_
2	,	,	,	,	_	21	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	action	action	NN	NN	_	21	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	dopamine	dopamine	NN	NN	_	4	nmod	_	_
7	on	on	IN	IN	_	10	case	_	_
8	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
9	gene	gene	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	4	nmod	_	_
11	in	in	IN	IN	_	12	case	_	_
12	cells	cell	NNS	NNS	_	4	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	immune	immune	JJ	JJ	_	16	amod	_	_
16	system	system	NN	NN	_	12	nmod	_	_
17	has	have	VBZ	VBZ	_	21	aux	_	_
18	not	not	RB	RB	_	21	neg	_	_
19	yet	yet	RB	RB	_	21	advmod	_	_
20	been	be	VBN	VBN	_	21	auxpass	_	_
21	examined	examine	VBN	VBN	_	0	root	_	_
22	.	.	.	.	_	21	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	investigated	investigate	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	regulation	regulation	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	10	case	_	_
9	HIV-1	hiv-1	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	7	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	dopamine	dopamine	NN	NN	_	7	nmod	_	_
13	in	in	IN	IN	_	16	case	_	_
14	Jurkat	jurkat	NN	NN	_	16	compound	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	5	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	in	in	IN	IN	_	22	case	_	_
19	primary	primary	JJ	JJ	_	22	amod	_	_
20	blood	blood	NN	NN	_	22	compound	_	_
21	mononuclear	mononuclear	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	16	conj	_	_
23	(	(	-LRB-	-LRB-	_	24	punct	_	_
24	PBMC	pbmc	NN	NN	_	22	appos	_	_
25	)	)	-RRB-	-RRB-	_	24	punct	_	_
26	.	.	.	.	_	5	punct	_	_

1	HIV-1	hiv-1	NN	NN	_	2	compound	_	_
2	replication	replication	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	increased	increase	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	6	case	_	_
6	dopamine	dopamine	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	correlated	correlate	VBD	VBD	_	6	acl:relcl	_	_
10	with	with	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	increased	increase	VBN	VBN	_	13	amod	_	_
13	levels	level	NNS	NNS	_	9	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	HIV-1	hiv-1	NN	NN	_	16	compound	_	_
16	transactivation	transactivation	NN	NN	_	13	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Our	we	PRP$	PRP$	_	4	nmod:poss	_	_
2	transient	transient	JJ	JJ	_	4	amod	_	_
3	expression	expression	NN	NN	_	4	compound	_	_
4	data	datum	NNS	NNS	_	5	nsubj	_	_
5	revealed	reveal	VBD	VBD	_	0	root	_	_
6	that	that	IN	IN	_	8	mark	_	_
7	dopamine	dopamine	NN	NN	_	8	nsubj	_	_
8	stimulated	stimulate	VBD	VBD	_	5	ccomp	_	_
9	transcription	transcription	NN	NN	_	8	dobj	_	_
10	through	through	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
13	element	element	NN	NN	_	8	nmod	_	_
14	present	present	JJ	JJ	_	13	amod	_	_
15	in	in	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	long	long	JJ	JJ	_	19	amod	_	_
18	terminal	terminal	JJ	JJ	_	19	amod	_	_
19	repeat	repeat	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	importance	importance	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	NF-kappaB	nf-kappab	NN	NN	_	5	compound	_	_
5	sites	site	NNS	NNS	_	2	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	confirmed	confirm	VBN	VBN	_	0	root	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	using	use	VBG	VBG	_	7	advcl	_	_
10	vectors	vector	NNS	NNS	_	9	dobj	_	_
11	containing	contain	VBG	VBG	_	10	acl	_	_
12	wild-type	wild-type	JJ	JJ	_	11	dobj	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	mutant	mutant	JJ	JJ	_	12	conj	_	_
15	kappaB	kappab	NN	NN	_	16	compound	_	_
16	sites	site	NNS	NNS	_	12	dep	_	_
17	in	in	IN	IN	_	20	case	_	_
18	a	a	DT	DT	_	20	det	_	_
19	heterologous	heterologous	JJ	JJ	_	20	amod	_	_
20	promoter	promoter	NN	NN	_	11	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	Consistent	consistent	JJ	JJ	_	16	ccomp	_	_
2	with	with	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	role	role	NN	NN	_	1	nmod	_	_
5	of	of	IN	IN	_	6	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	4	nmod	_	_
7	in	in	IN	IN	_	8	mark	_	_
8	mediating	mediate	VBG	VBG	_	4	acl	_	_
9	dopamine	dopamine	NN	NN	_	10	compound	_	_
10	responsiveness	responsiveness	NN	NN	_	8	dobj	_	_
11	,	,	,	,	_	16	punct	_	_
12	the	the	DT	DT	_	15	det	_	_
13	proteasome	proteasome	NN	NN	_	15	compound	_	_
14	inhibitor	inhibitor	NN	NN	_	15	compound	_	_
15	MG132	mg132	NN	NN	_	16	nsubj	_	_
16	abolished	abolish	VBD	VBD	_	0	root	_	_
17	dopamine-induced	dopamine-induced	JJ	JJ	_	19	amod	_	_
18	transcriptional	transcriptional	JJ	JJ	_	19	amod	_	_
19	activation	activation	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	explored	explore	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	dopamine	dopamine	NN	NN	_	5	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	presence	presence	NN	NN	_	3	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	phorbol	phorbol	NN	NN	_	13	compound	_	_
13	esters	ester	NNS	NNS	_	10	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	tumor	tumor	NN	NN	_	17	compound	_	_
16	necrosis	necrosis	NN	NN	_	17	compound	_	_
17	factor-alpha	factor-alpha	NN	NN	_	13	conj	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	TNF-alpha	tnf-alpha	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	known	know	VBN	VBN	_	17	acl	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	activate	activate	VB	VB	_	21	xcomp	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	23	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	combination	combination	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	dopamine	dopamine	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	4	conj	_	_
7	led	lead	VBD	VBD	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	stimulation	stimulation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	12	case	_	_
12	HIV-1	hiv-1	NN	NN	_	10	nmod	_	_
13	transcription	transcription	NN	NN	_	12	dep	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	replication	replication	NN	NN	_	13	conj	_	_
16	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	12	advmod	_	_
2	,	,	,	,	_	12	punct	_	_
3	in	in	IN	IN	_	4	case	_	_
4	contrast	contrast	NN	NN	_	12	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	TNF-alpha	tnf-alpha	NN	NN	_	4	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	dopamine	dopamine	NN	NN	_	9	compound	_	_
9	treatment	treatment	NN	NN	_	12	nsubj	_	_
10	did	do	VBD	VBD	_	12	aux	_	_
11	not	not	RB	RB	_	12	neg	_	_
12	affect	affect	VB	VB	_	0	root	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	16	compound	_	_
14	DNA	dna	NN	NN	_	16	compound	_	_
15	binding	binding	NN	NN	_	16	compound	_	_
16	activity	activity	NN	NN	_	12	dobj	_	_
17	nor	nor	CC	CC	_	16	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	concentrations	concentration	NNS	NNS	_	16	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	p50	p50	NN	NN	_	19	nmod	_	_
22	,	,	,	,	_	21	punct	_	_
23	p65	p65	NN	NN	_	21	conj	_	_
24	and	and	CC	CC	_	21	cc	_	_
25	IkappaB-alpha	ikappab-alpha	NN	NN	_	26	compound	_	_
26	proteins	protein	NNS	NNS	_	21	conj	_	_
27	,	,	,	,	_	26	punct	_	_
28	which	which	WDT	WDT	_	29	nsubj	_	_
29	suggests	suggest	VBZ	VBZ	_	26	acl:relcl	_	_
30	a	a	DT	DT	_	34	det	_	_
31	distinct	distinct	JJ	JJ	_	34	amod	_	_
32	NF-kappaB	nf-kappab	NN	NN	_	34	compound	_	_
33	activation	activation	NN	NN	_	34	compound	_	_
34	mechanism	mechanism	NN	NN	_	29	dobj	_	_
35	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	reveal	reveal	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	new	new	JJ	JJ	_	6	amod	_	_
6	link	link	NN	NN	_	3	dobj	_	_
7	between	between	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	dep	_	_
9	dopamine	dopamine	NN	NN	_	10	compound	_	_
10	system	system	NN	NN	_	6	nmod	_	_
11	,	,	,	,	_	10	punct	_	_
12	cytokine	cytokine	NN	NN	_	14	compound	_	_
13	signaling	signaling	NN	NN	_	14	compound	_	_
14	pathway	pathway	NN	NN	_	10	conj	_	_
15	and	and	CC	CC	_	10	cc	_	_
16	regulation	regulation	NN	NN	_	10	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	gene	gene	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	16	nmod	_	_
20	via	via	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	involvement	involvement	NN	NN	_	3	nmod	_	_
23	of	of	IN	IN	_	24	case	_	_
24	NF-kappaB	nf-kappab	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	22	nmod	_	_
28	and	and	CC	CC	_	27	cc	_	_
29	PBMC	pbmc	NN	NN	_	27	conj	_	_
30	.	.	.	.	_	3	punct	_	_

1	Differential	differential	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	4	case	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	2	nmod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	tumor	tumor	NN	NN	_	8	compound	_	_
7	necrosis	necrosis	NN	NN	_	8	compound	_	_
8	factor	factor	NN	NN	_	4	conj	_	_
9	on	on	IN	IN	_	14	case	_	_
10	monocytic	monocytic	JJ	JJ	_	14	amod	_	_
11	IkappaB	ikappab	NN	NN	_	14	compound	_	_
12	kinase	kinase	NN	NN	_	14	compound	_	_
13	signalsome	signalsome	JJ	JJ	_	14	amod	_	_
14	activation	activation	NN	NN	_	2	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	IkappaB	ikappab	NN	NN	_	17	compound	_	_
17	proteolysis	proteolysis	NN	NN	_	14	conj	_	_
18	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inflammatory	inflammatory	JJ	JJ	_	3	amod	_	_
3	mediators	mediator	NNS	NNS	_	17	nsubj	_	_
4	lipopolysaccharide	lipopolysaccharide	NN	NN	_	3	dep	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	LPS	lps	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	and	and	CC	CC	_	4	cc	_	_
9	tumor	tumor	NN	NN	_	11	compound	_	_
10	necrosis	necrosis	NN	NN	_	11	compound	_	_
11	factor	factor	NN	NN	_	4	conj	_	_
12	(	(	-LRB-	-LRB-	_	13	punct	_	_
13	TNF	tnf	NN	NN	_	11	appos	_	_
14	)	)	-RRB-	-RRB-	_	13	punct	_	_
15	are	be	VBP	VBP	_	17	cop	_	_
16	potent	potent	JJ	JJ	_	17	amod	_	_
17	activators	activator	NNS	NNS	_	0	root	_	_
18	of	of	IN	IN	_	19	case	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	17	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	study	study	NN	NN	_	3	nsubj	_	_
3	compared	compare	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	effect	effect	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	these	these	DT	DT	_	8	det	_	_
8	stimuli	stimulus	NNS	NNS	_	5	nmod	_	_
9	on	on	IN	IN	_	17	case	_	_
10	endogenous	endogenous	JJ	JJ	_	17	amod	_	_
11	IkappaB	ikappab	NN	NN	_	17	compound	_	_
12	kinase	kinase	NN	NN	_	17	compound	_	_
13	(	(	-LRB-	-LRB-	_	17	punct	_	_
14	IKK	ikk	NN	NN	_	17	compound	_	_
15	)	)	-RRB-	-RRB-	_	17	punct	_	_
16	signalsome	signalsome	JJ	JJ	_	17	amod	_	_
17	activation	activation	NN	NN	_	5	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	IkappaB	ikappab	NN	NN	_	20	compound	_	_
20	phosphorylation/proteolysis	phosphorylation/proteolysis	NN	NN	_	17	conj	_	_
21	in	in	IN	IN	_	24	case	_	_
22	human	human	JJ	JJ	_	24	amod	_	_
23	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
24	cells	cell	NNS	NNS	_	5	nmod	_	_
25	and	and	CC	CC	_	3	cc	_	_
26	investigated	investigate	VBD	VBD	_	3	conj	_	_
27	the	the	DT	DT	_	28	det	_	_
28	role	role	NN	NN	_	26	dobj	_	_
29	of	of	IN	IN	_	32	case	_	_
30	the	the	DT	DT	_	32	det	_	_
31	signalsome	signalsome	JJ	JJ	_	32	amod	_	_
32	proteins	protein	NNS	NNS	_	28	nmod	_	_
33	IKK-alpha	ikk-alpha	NN	NN	_	32	dep	_	_
34	,	,	,	,	_	33	punct	_	_
35	IKK-beta	ikk-beta	NN	NN	_	33	conj	_	_
36	,	,	,	,	_	33	punct	_	_
37	NF-kappaB-inducing	nf-kappab-inducing	JJ	JJ	_	38	amod	_	_
38	kinase	kinase	NN	NN	_	33	conj	_	_
39	(	(	-LRB-	-LRB-	_	40	punct	_	_
40	NIK	nik	NN	NN	_	38	appos	_	_
41	)	)	-RRB-	-RRB-	_	40	punct	_	_
42	,	,	,	,	_	33	punct	_	_
43	IKK-gamma	ikk-gamma	NN	NN	_	33	conj	_	_
44	(	(	-LRB-	-LRB-	_	47	punct	_	_
45	NF-kappaB	nf-kappab	NN	NN	_	47	compound	_	_
46	essential	essential	JJ	JJ	_	47	amod	_	_
47	modulator	modulator	NN	NN	_	43	appos	_	_
48	)	)	-RRB-	-RRB-	_	47	punct	_	_
49	,	,	,	,	_	33	punct	_	_
50	and	and	CC	CC	_	33	cc	_	_
51	IKK	ikk	NN	NN	_	53	compound	_	_
52	complex-associated	complex-associated	JJ	JJ	_	53	amod	_	_
53	protein	protein	NN	NN	_	33	conj	_	_
54	.	.	.	.	_	3	punct	_	_

1	Kinase	kinase	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TNF	tnf	NN	NN	_	6	nsubj	_	_
6	elicited	elicit	VBD	VBD	_	3	ccomp	_	_
7	a	a	DT	DT	_	11	det	_	_
8	rapid	rapid	JJ	JJ	_	11	amod	_	_
9	but	but	CC	CC	_	8	cc	_	_
10	short-lived	short-lived	JJ	JJ	_	8	conj	_	_
11	induction	induction	NN	NN	_	6	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	IKK	ikk	NN	NN	_	14	compound	_	_
14	activity	activity	NN	NN	_	11	nmod	_	_
15	with	with	IN	IN	_	19	case	_	_
16	a	a	DT	DT	_	19	det	_	_
17	3-fold	3-fold	JJ	JJ	_	19	amod	_	_
18	greater	greater	JJR	JJR	_	19	amod	_	_
19	effect	effect	NN	NN	_	6	nmod	_	_
20	on	on	IN	IN	_	21	case	_	_
21	IKK-alpha	ikk-alpha	NN	NN	_	19	nmod	_	_
22	than	than	IN	IN	_	24	case	_	_
23	on	on	IN	IN	_	24	case	_	_
24	IKK-beta	ikk-beta	NN	NN	_	19	nmod	_	_
25	,	,	,	,	_	19	punct	_	_
26	peaking	peak	VBG	VBG	_	19	acl	_	_
27	at	at	IN	IN	_	29	case	_	_
28	5	5	CD	CD	_	29	nummod	_	_
29	min	min	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	LPS	lps	NN	NN	_	6	nsubj	_	_
5	predominantly	predominantly	RB	RB	_	6	advmod	_	_
6	stimulated	stimulate	VBD	VBD	_	0	root	_	_
7	IKK-beta	ikk-beta	NN	NN	_	8	compound	_	_
8	activity	activity	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	which	which	WDT	WDT	_	12	nsubj	_	_
11	slowly	slowly	RB	RB	_	12	advmod	_	_
12	increased	increase	VBD	VBD	_	8	acl:relcl	_	_
13	,	,	,	,	_	12	punct	_	_
14	peaking	peak	VBG	VBG	_	12	xcomp	_	_
15	at	at	IN	IN	_	17	case	_	_
16	30	30	CD	CD	_	17	nummod	_	_
17	min	min	NN	NN	_	14	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	A	a	DT	DT	_	3	det	_	_
2	second	second	JJ	JJ	_	3	amod	_	_
3	peak	peak	NN	NN	_	5	nsubjpass	_	_
4	was	be	VBD	VBD	_	5	auxpass	_	_
5	observed	observe	VBN	VBN	_	0	root	_	_
6	at	at	IN	IN	_	10	case	_	_
7	a	a	DT	DT	_	10	det	_	_
8	later	later	JJ	JJ	_	10	amod	_	_
9	time	time	NN	NN	_	10	compound	_	_
10	point	point	NN	NN	_	5	nmod	_	_
11	following	follow	VBG	VBG	_	13	case	_	_
12	LPS	lps	NN	NN	_	13	compound	_	_
13	stimulation	stimulation	NN	NN	_	10	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	16	nsubj	_	_
16	consisted	consist	VBD	VBD	_	13	acl:relcl	_	_
17	of	of	IN	IN	_	19	case	_	_
18	both	both	CC	CC	_	19	cc:preconj	_	_
19	IKK-alpha	ikk-alpha	NN	NN	_	16	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	-beta	-beta	NN	NN	_	19	conj	_	_
22	activity	activity	NN	NN	_	19	dep	_	_
23	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	endogenous	endogenous	JJ	JJ	_	3	amod	_	_
3	levels	level	NNS	NNS	_	9	nsubj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	the	the	DT	DT	_	7	det	_	_
6	signalsome	signalsome	JJ	JJ	_	7	amod	_	_
7	components	component	NNS	NNS	_	3	nmod	_	_
8	were	be	VBD	VBD	_	9	aux	_	_
9	unaffected	unaffected	JJ	JJ	_	0	root	_	_
10	by	by	IN	IN	_	11	case	_	_
11	stimulation	stimulation	NN	NN	_	9	nmod	_	_
12	.	.	.	.	_	9	punct	_	_

1	Furthermore	furthermore	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	studies	study	NNS	NNS	_	5	nsubj	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	association	association	NN	NN	_	5	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	IKK-alpha/beta	ikk-alpha/beta	NN	NN	_	10	compound	_	_
10	heterodimer	heterodimer	NN	NN	_	6	nmod	_	_
11	with	with	IN	IN	_	12	case	_	_
12	NIK	nik	NN	NN	_	6	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	IkappaB-alpha	ikappab-alpha	NN	NN	_	12	conj	_	_
15	and	and	CC	CC	_	12	cc	_	_
16	-epsilon	-epsilon	NN	NN	_	12	conj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	unstimulated	unstimulated	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	6	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Exposure	exposure	NN	NN	_	6	nsubj	_	_
2	to	to	TO	TO	_	3	case	_	_
3	LPS	lps	NN	NN	_	1	nmod	_	_
4	or	or	CC	CC	_	3	cc	_	_
5	TNF	tnf	NN	NN	_	3	conj	_	_
6	led	lead	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	differential	differential	JJ	JJ	_	9	amod	_	_
9	patterns	pattern	NNS	NNS	_	6	nmod	_	_
10	of	of	IN	IN	_	14	case	_	_
11	IkappaB-alpha	ikappab-alpha	NN	NN	_	14	compound	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	IkappaB-epsilon	ikappab-epsilon	NN	NN	_	11	conj	_	_
14	disappearance	disappearance	NN	NN	_	9	nmod	_	_
15	from	from	IN	IN	_	20	nmod	_	_
16	and	and	CC	CC	_	20	cc	_	_
17	reassembly	reassembly	NN	NN	_	18	dep	_	_
18	with	with	IN	IN	_	20	conj	_	_
19	the	the	DT	DT	_	20	det	_	_
20	signalsome	signalsome	JJ	JJ	_	14	nmod	_	_
21	,	,	,	,	_	6	punct	_	_
22	whereas	whereas	IN	IN	_	6	dep	_	_
23	IKK-alpha	ikk-alpha	NN	NN	_	29	nsubj	_	_
24	,	,	,	,	_	23	punct	_	_
25	IKK-beta	ikk-beta	NN	NN	_	23	conj	_	_
26	,	,	,	,	_	23	punct	_	_
27	and	and	CC	CC	_	23	cc	_	_
28	NIK	nik	NN	NN	_	23	conj	_	_
29	remained	remain	VBD	VBD	_	6	parataxis	_	_
30	complex-associated	complex-associated	JJ	JJ	_	29	xcomp	_	_
31	.	.	.	.	_	6	punct	_	_

1	NIK	nik	NN	NN	_	4	nsubj	_	_
2	can	can	MD	MD	_	4	aux	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	phosphorylate	phosphorylate	VB	VB	_	0	root	_	_
5	IkappaB-alpha	ikappab-alpha	NN	NN	_	4	dobj	_	_
6	directly	directly	RB	RB	_	4	advmod	_	_
7	,	,	,	,	_	4	punct	_	_
8	but	but	CC	CC	_	4	cc	_	_
9	it	it	PRP	PRP	_	10	nsubj	_	_
10	appears	appear	VBZ	VBZ	_	4	conj	_	_
11	to	to	TO	TO	_	16	mark	_	_
12	be	be	VB	VB	_	16	cop	_	_
13	a	a	DT	DT	_	16	det	_	_
14	functionally	functionally	RB	RB	_	15	advmod	_	_
15	important	important	JJ	JJ	_	16	amod	_	_
16	subunit	subunit	NN	NN	_	10	xcomp	_	_
17	,	,	,	,	_	16	punct	_	_
18	because	because	IN	IN	_	21	mark	_	_
19	mutated	mutate	VBN	VBN	_	20	amod	_	_
20	NIK	nik	NN	NN	_	21	nsubj	_	_
21	inhibited	inhibit	VBD	VBD	_	16	advcl	_	_
22	stimulus-induced	stimulus-induced	JJ	JJ	_	24	amod	_	_
23	kappaB-dependent	kappab-dependent	JJ	JJ	_	24	amod	_	_
24	transcription	transcription	NN	NN	_	21	dobj	_	_
25	more	more	JJR	JJR	_	26	dep	_	_
26	effectively	effectively	RB	RB	_	21	advmod	_	_
27	than	than	IN	IN	_	29	case	_	_
28	mutated	mutate	VBN	VBN	_	29	amod	_	_
29	IKK-alpha	ikk-alpha	NN	NN	_	26	nmod	_	_
30	or	or	CC	CC	_	29	cc	_	_
31	-beta	-beta	NN	NN	_	29	conj	_	_
32	.	.	.	.	_	4	punct	_	_

1	Overexpression	overexpression	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IKK	ikk	NN	NN	_	5	compound	_	_
4	complex-associated	complex-associated	JJ	JJ	_	5	amod	_	_
5	protein	protein	NN	NN	_	1	nmod	_	_
6	inhibited	inhibit	VBD	VBD	_	0	root	_	_
7	stimulus-mediated	stimulus-mediated	JJ	JJ	_	8	amod	_	_
8	transcription	transcription	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	6	punct	_	_
10	whereas	whereas	IN	IN	_	6	dep	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
12	essential	essential	JJ	JJ	_	13	amod	_	_
13	modulator	modulator	NN	NN	_	14	nsubj	_	_
14	enhanced	enhance	VBD	VBD	_	6	parataxis	_	_
15	it	it	PRP	PRP	_	14	dobj	_	_
16	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	understanding	understanding	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	7	case	_	_
4	LPS-	lps-	NN	NN	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	TNF-induced	tnf-induced	JJ	JJ	_	4	conj	_	_
7	signaling	signaling	NN	NN	_	2	nmod	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	allow	allow	VB	VB	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	development	development	NN	NN	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	specific	specific	JJ	JJ	_	14	amod	_	_
14	strategies	strategy	NNS	NNS	_	11	nmod	_	_
15	to	to	TO	TO	_	16	mark	_	_
16	treat	treat	VB	VB	_	14	acl	_	_
17	sepsis-associated	sepsis-associated	JJ	JJ	_	18	amod	_	_
18	disease	disease	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	9	punct	_	_

1	AML1	aml1	NN	NN	_	3	compound	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	CBFalpha2	cbfalpha2	NN	NN	_	5	nsubj	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	cooperates	cooperate	VBZ	VBZ	_	0	root	_	_
6	with	with	IN	IN	_	12	case	_	_
7	B	b	NN	NN	_	12	compound	_	_
8	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
9	activating	activate	VBG	VBG	_	12	amod	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	BSAP/PAX5	bsap/pax5	NN	NN	_	5	nmod	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	in	in	IN	IN	_	15	case	_	_
15	activation	activation	NN	NN	_	5	nmod	_	_
16	of	of	IN	IN	_	22	case	_	_
17	the	the	DT	DT	_	22	det	_	_
18	B	b	NN	NN	_	22	compound	_	_
19	cell-specific	cell-specific	JJ	JJ	_	22	amod	_	_
20	BLK	blk	NN	NN	_	22	compound	_	_
21	gene	gene	NN	NN	_	22	compound	_	_
22	promoter	promoter	NN	NN	_	15	nmod	_	_
23	.	.	.	.	_	5	punct	_	_

1	AML1	aml1	NN	NN	_	2	nsubj	_	_
2	plays	play	VBZ	VBZ	_	0	root	_	_
3	a	a	DT	DT	_	5	det	_	_
4	critical	critical	JJ	JJ	_	5	amod	_	_
5	role	role	NN	NN	_	2	dobj	_	_
6	during	during	IN	IN	_	7	case	_	_
7	hematopoiesis	hematopoiesis	NN	NN	_	2	nmod	_	_
8	and	and	CC	CC	_	2	cc	_	_
9	chromosomal	chromosomal	JJ	JJ	_	10	amod	_	_
10	translocations	translocation	NNS	NNS	_	15	nsubjpass	_	_
11	involving	involve	VBG	VBG	_	10	acl	_	_
12	AML1	aml1	NN	NN	_	11	dobj	_	_
13	are	be	VBP	VBP	_	15	auxpass	_	_
14	commonly	commonly	RB	RB	_	15	advmod	_	_
15	associated	associate	VBN	VBN	_	2	conj	_	_
16	with	with	IN	IN	_	18	case	_	_
17	different	different	JJ	JJ	_	18	amod	_	_
18	forms	form	NNS	NNS	_	15	nmod	_	_
19	of	of	IN	IN	_	20	case	_	_
20	leukemia	leukemia	NN	NN	_	18	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	including	include	VBG	VBG	_	26	case	_	_
23	pre-B	pre-b	JJ	JJ	_	26	amod	_	_
24	acute	acute	JJ	JJ	_	26	amod	_	_
25	lymphoblastic	lymphoblastic	JJ	JJ	_	26	amod	_	_
26	leukemia	leukemia	NN	NN	_	20	nmod	_	_
27	.	.	.	.	_	2	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	understand	understand	VB	VB	_	13	advcl	_	_
3	the	the	DT	DT	_	4	det	_	_
4	function	function	NN	NN	_	2	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	AML1	aml1	NN	NN	_	4	nmod	_	_
7	during	during	IN	IN	_	10	case	_	_
8	B	b	NN	NN	_	10	compound	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	differentiation	differentiation	NN	NN	_	4	nmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	analyzed	analyze	VBD	VBD	_	0	root	_	_
14	regulatory	regulatory	JJ	JJ	_	15	amod	_	_
15	regions	region	NNS	NNS	_	13	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	B	b	NN	NN	_	19	compound	_	_
18	cell-specific	cell-specific	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	15	nmod	_	_
20	for	for	IN	IN	_	23	case	_	_
21	potential	potential	JJ	JJ	_	23	amod	_	_
22	AML1-binding	aml1-binding	JJ	JJ	_	23	amod	_	_
23	sites	site	NNS	NNS	_	15	nmod	_	_
24	and	and	CC	CC	_	13	cc	_	_
25	have	have	VBP	VBP	_	26	aux	_	_
26	identified	identify	VBN	VBN	_	13	conj	_	_
27	a	a	DT	DT	_	30	det	_	_
28	putative	putative	JJ	JJ	_	30	amod	_	_
29	AML1-binding	aml1-binding	JJ	JJ	_	30	amod	_	_
30	site	site	NN	NN	_	26	dobj	_	_
31	in	in	IN	IN	_	33	case	_	_
32	the	the	DT	DT	_	33	det	_	_
33	promoter	promoter	NN	NN	_	30	nmod	_	_
34	of	of	IN	IN	_	42	case	_	_
35	the	the	DT	DT	_	42	det	_	_
36	B	b	NN	NN	_	42	compound	_	_
37	cell-specific	cell-specific	JJ	JJ	_	42	amod	_	_
38	tyrosine	tyrosine	NN	NN	_	42	compound	_	_
39	kinase	kinase	NN	NN	_	42	compound	_	_
40	gene	gene	NN	NN	_	42	compound	_	_
41	,	,	,	,	_	42	punct	_	_
42	blk	blk	NN	NN	_	33	nmod	_	_
43	.	.	.	.	_	13	punct	_	_

1	Gel	gel	NN	NN	_	4	compound	_	_
2	mobility	mobility	NN	NN	_	4	compound	_	_
3	shift	shift	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	9	nsubj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	transient	transient	JJ	JJ	_	8	amod	_	_
7	transfection	transfection	NN	NN	_	8	compound	_	_
8	assays	assay	NNS	NNS	_	4	conj	_	_
9	demonstrate	demonstrate	VBP	VBP	_	26	dep	_	_
10	that	that	IN	IN	_	12	mark	_	_
11	AML1	aml1	NN	NN	_	12	nsubj	_	_
12	binds	bind	VBZ	VBZ	_	9	ccomp	_	_
13	specifically	specifically	RB	RB	_	12	advmod	_	_
14	to	to	TO	TO	_	16	case	_	_
15	this	this	DT	DT	_	16	det	_	_
16	site	site	NN	NN	_	12	nmod	_	_
17	in	in	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	blk	blk	NN	NN	_	20	compound	_	_
20	promoter	promoter	NN	NN	_	16	nmod	_	_
21	and	and	CC	CC	_	26	cc	_	_
22	this	this	DT	DT	_	24	det	_	_
23	binding	bind	VBG	VBG	_	24	amod	_	_
24	site	site	NN	NN	_	26	conj	_	_
25	is	be	VBZ	VBZ	_	26	cop	_	_
26	important	important	JJ	JJ	_	0	root	_	_
27	for	for	IN	IN	_	30	case	_	_
28	blk	blk	NN	NN	_	30	compound	_	_
29	promoter	promoter	NN	NN	_	30	compound	_	_
30	activity	activity	NN	NN	_	26	nmod	_	_
31	.	.	.	.	_	26	punct	_	_

1	Furthermore	furthermore	RB	RB	_	7	advmod	_	_
2	,	,	,	,	_	7	punct	_	_
3	in	in	FW	FW	_	6	compound	_	_
4	vitro	vitro	FW	FW	_	6	compound	_	_
5	binding	binding	NN	NN	_	6	compound	_	_
6	analysis	analysis	NN	NN	_	7	nsubj	_	_
7	revealed	reveal	VBD	VBD	_	0	root	_	_
8	that	that	IN	IN	_	15	mark	_	_
9	the	the	DT	DT	_	13	det	_	_
10	AML1	aml1	NN	NN	_	13	compound	_	_
11	runt	runt	NN	NN	_	13	compound	_	_
12	DNA-binding	dna-binding	NN	NN	_	13	compound	_	_
13	domain	domain	NN	NN	_	15	nsubj	_	_
14	physically	physically	RB	RB	_	15	advmod	_	_
15	interacts	interact	VBZ	VBZ	_	7	ccomp	_	_
16	with	with	IN	IN	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	paired	paired	JJ	JJ	_	20	amod	_	_
19	DNA-binding	dna-binding	JJ	JJ	_	20	amod	_	_
20	domain	domain	NN	NN	_	15	nmod	_	_
21	of	of	IN	IN	_	22	case	_	_
22	BSAP	bsap	NN	NN	_	20	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	a	a	DT	DT	_	28	det	_	_
25	B	b	NN	NN	_	28	compound	_	_
26	cell-specific	cell-specific	JJ	JJ	_	28	amod	_	_
27	transcription	transcription	NN	NN	_	28	compound	_	_
28	factor	factor	NN	NN	_	22	appos	_	_
29	.	.	.	.	_	7	punct	_	_

1	BSAP	bsap	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	previously	previously	RB	RB	_	4	advmod	_	_
6	to	to	TO	TO	_	8	mark	_	_
7	be	be	VB	VB	_	8	cop	_	_
8	important	important	JJ	JJ	_	4	xcomp	_	_
9	for	for	IN	IN	_	12	case	_	_
10	B	b	NN	NN	_	12	compound	_	_
11	cell-specific	cell-specific	JJ	JJ	_	12	amod	_	_
12	regulation	regulation	NN	NN	_	8	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	the	the	DT	DT	_	16	det	_	_
15	blk	blk	NN	NN	_	16	compound	_	_
16	gene	gene	NN	NN	_	12	nmod	_	_
17	.	.	.	.	_	4	punct	_	_

1	Physical	physical	JJ	JJ	_	2	amod	_	_
2	interaction	interaction	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	AML1	aml1	NN	NN	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	BSAP	bsap	NN	NN	_	2	nmod	_	_
7	correlates	correlate	VBZ	VBZ	_	0	root	_	_
8	with	with	IN	IN	_	10	case	_	_
9	functional	functional	JJ	JJ	_	10	amod	_	_
10	cooperativity	cooperativity	NN	NN	_	7	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	transfection	transfection	NN	NN	_	13	compound	_	_
13	studies	study	NNS	NNS	_	10	nmod	_	_
14	where	where	WRB	WRB	_	19	advmod	_	_
15	AML1	aml1	NN	NN	_	19	nsubj	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	BSAP	bsap	NN	NN	_	15	conj	_	_
18	synergistically	synergistically	RB	RB	_	19	advmod	_	_
19	activate	activate	VBP	VBP	_	13	acl:relcl	_	_
20	blk	blk	NN	NN	_	22	compound	_	_
21	promoter	promoter	NN	NN	_	22	compound	_	_
22	transcription	transcription	NN	NN	_	19	dobj	_	_
23	by	by	IN	IN	_	24	case	_	_
24	more	more	JJR	JJR	_	19	nmod	_	_
25	than	than	IN	IN	_	24	amod	_	_
26	50-fold	50-fold	JJ	JJ	_	24	amod	_	_
27	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	physical	physical	JJ	JJ	_	7	amod	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	functional	functional	JJ	JJ	_	4	conj	_	_
7	interactions	interaction	NNS	NNS	_	3	dobj	_	_
8	between	between	IN	IN	_	9	case	_	_
9	AML1	aml1	NN	NN	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	BSAP	bsap	NN	NN	_	9	conj	_	_
12	and	and	CC	CC	_	3	cc	_	_
13	suggest	suggest	VB	VB	_	3	conj	_	_
14	that	that	IN	IN	_	19	mark	_	_
15	AML1	aml1	NN	NN	_	19	nsubj	_	_
16	is	be	VBZ	VBZ	_	19	cop	_	_
17	an	a	DT	DT	_	19	det	_	_
18	important	important	JJ	JJ	_	19	amod	_	_
19	factor	factor	NN	NN	_	13	ccomp	_	_
20	for	for	IN	IN	_	21	mark	_	_
21	regulating	regulate	VBG	VBG	_	19	acl	_	_
22	a	a	DT	DT	_	28	det	_	_
23	critical	critical	JJ	JJ	_	28	amod	_	_
24	B	b	NN	NN	_	28	compound	_	_
25	cell-specific	cell-specific	JJ	JJ	_	28	amod	_	_
26	gene	gene	NN	NN	_	28	compound	_	_
27	,	,	,	,	_	28	punct	_	_
28	blk	blk	NN	NN	_	21	dobj	_	_
29	.	.	.	.	_	3	punct	_	_

1	Gender	gender	NN	NN	_	0	root	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	vascular	vascular	JJ	JJ	_	4	amod	_	_
4	reactivity	reactivity	NN	NN	_	1	conj	_	_
5	.	.	.	.	_	1	punct	_	_

1	Estrogen	estrogen	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	4	nsubjpass	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	on	on	IN	IN	_	7	case	_	_
6	vascular	vascular	JJ	JJ	_	7	amod	_	_
7	endothelial	endothelial	JJ	JJ	_	4	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	smooth	smooth	VB	VB	_	10	dep	_	_
10	muscle	muscle	NN	NN	_	7	conj	_	_
11	cells	cell	NNS	NNS	_	7	dep	_	_
12	;	;	:	:	_	4	punct	_	_
13	their	they	PRP$	PRP$	_	14	nmod:poss	_	_
14	expression	expression	NN	NN	_	16	nsubjpass	_	_
15	is	be	VBZ	VBZ	_	16	auxpass	_	_
16	influenced	influence	VBN	VBN	_	4	parataxis	_	_
17	by	by	IN	IN	_	18	case	_	_
18	exposure	exposure	NN	NN	_	16	nmod	_	_
19	to	to	TO	TO	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	hormone	hormone	NN	NN	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Estrogen	estrogen	NN	NN	_	2	compound	_	_
2	receptors	receptor	NNS	NNS	_	3	nsubj	_	_
3	influence	influence	VBP	VBP	_	0	root	_	_
4	non-genomic	non-genomic	JJ	JJ	_	5	amod	_	_
5	events	event	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	5	punct	_	_
7	which	which	WDT	WDT	_	9	nsubj	_	_
8	are	be	VBP	VBP	_	9	cop	_	_
9	rapid	rapid	JJ	JJ	_	5	acl:relcl	_	_
10	in	in	IN	IN	_	11	case	_	_
11	onset	onset	NN	NN	_	9	nmod	_	_
12	and	and	CC	CC	_	5	cc	_	_
13	genomic	genomic	JJ	JJ	_	14	amod	_	_
14	events	event	NNS	NNS	_	5	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	which	which	WDT	WDT	_	20	nsubj	_	_
17	are	be	VBP	VBP	_	20	cop	_	_
18	longer	longer	RBR	RBR	_	20	advmod	_	_
19	acting	acting	NN	NN	_	20	compound	_	_
20	responses	response	NNS	NNS	_	14	acl:relcl	_	_
21	.	.	.	.	_	3	punct	_	_

1	Estrogens	estrogen	NNS	NNS	_	2	nsubj	_	_
2	affect	affect	VBP	VBP	_	0	root	_	_
3	vascular	vascular	JJ	JJ	_	4	amod	_	_
4	tone	tone	NN	NN	_	2	dobj	_	_
5	indirectly	indirectly	RB	RB	_	2	dep	_	_
6	by	by	IN	IN	_	7	mark	_	_
7	modulating	modulate	VBG	VBG	_	5	nmod	_	_
8	release	release	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	12	case	_	_
10	endothelium-derived	endothelium-derived	JJ	JJ	_	12	amod	_	_
11	vasoactive	vasoactive	JJ	JJ	_	12	amod	_	_
12	factors	factor	NNS	NNS	_	8	nmod	_	_
13	and	and	CC	CC	_	5	cc	_	_
14	directly	directly	RB	RB	_	16	advmod	_	_
15	by	by	IN	IN	_	16	mark	_	_
16	modulating	modulate	VBG	VBG	_	5	conj	_	_
17	intracellular	intracellular	JJ	JJ	_	18	amod	_	_
18	calcium	calcium	NN	NN	_	16	dobj	_	_
19	in	in	IN	IN	_	23	case	_	_
20	vascular	vascular	JJ	JJ	_	23	amod	_	_
21	smooth	smooth	NN	NN	_	23	compound	_	_
22	muscle	muscle	NN	NN	_	23	compound	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	.	.	.	.	_	2	punct	_	_

1	Estrogens	estrogen	NNS	NNS	_	3	nsubj	_	_
2	indirectly	indirectly	RB	RB	_	3	advmod	_	_
3	affect	affect	VBP	VBP	_	0	root	_	_
4	thrombotic	thrombotic	JJ	JJ	_	5	amod	_	_
5	events	event	NNS	NNS	_	3	dobj	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	inflammation	inflammation	NN	NN	_	5	conj	_	_
8	by	by	IN	IN	_	9	mark	_	_
9	altering	alter	VBG	VBG	_	3	advcl	_	_
10	platelet	platelet	NN	NN	_	11	compound	_	_
11	aggregation	aggregation	NN	NN	_	9	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	leukocyte	leukocyte	NN	NN	_	11	conj	_	_
14	adherence	adherence	NN	NN	_	13	dep	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	migration	migration	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	9	punct	_	_
18	respectively	respectively	RB	RB	_	9	advmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Estrogens	estrogen	NNS	NNS	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	influence	influence	VBP	VBP	_	0	root	_	_
4	production	production	NN	NN	_	3	dobj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	mitogens	mitogen	NNS	NNS	_	4	nmod	_	_
7	which	which	WDT	WDT	_	17	dep	_	_
8	,	,	,	,	_	17	punct	_	_
9	when	when	WRB	WRB	_	10	advmod	_	_
10	released	release	VBN	VBN	_	17	dep	_	_
11	at	at	IN	IN	_	12	case	_	_
12	sites	site	NNS	NNS	_	10	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	vascular	vascular	JJ	JJ	_	15	amod	_	_
15	injury	injury	NN	NN	_	12	nmod	_	_
16	,	,	,	,	_	17	punct	_	_
17	affect	affect	VBP	VBP	_	6	acl:relcl	_	_
18	vascular	vascular	JJ	JJ	_	19	amod	_	_
19	remodeling	remodeling	NN	NN	_	17	dobj	_	_
20	.	.	.	.	_	3	punct	_	_

1	Although	although	IN	IN	_	3	mark	_	_
2	estrogens	estrogen	NNS	NNS	_	3	nsubj	_	_
3	initiate	initiate	VBP	VBP	_	10	advcl	_	_
4	vascular	vascular	JJ	JJ	_	5	amod	_	_
5	responses	response	NNS	NNS	_	3	dobj	_	_
6	,	,	,	,	_	10	punct	_	_
7	genomic	genomic	JJ	JJ	_	8	amod	_	_
8	sex	sex	NN	NN	_	10	nsubj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	influence	influence	VB	VB	_	0	root	_	_
11	and/or	and/or	CC	CC	_	10	cc	_	_
12	limit	limit	VB	VB	_	10	conj	_	_
13	expression	expression	NN	NN	_	10	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	estrogen	estrogen	NN	NN	_	16	compound	_	_
16	receptors	receptor	NNS	NNS	_	13	nmod	_	_
17	and	and	CC	CC	_	13	cc	_	_
18	therefore	therefore	RB	RB	_	19	advmod	_	_
19	actions	action	NNS	NNS	_	13	conj	_	_
20	of	of	IN	IN	_	23	case	_	_
21	sex	sex	NN	NN	_	23	compound	_	_
22	steroid	steroid	NN	NN	_	23	compound	_	_
23	hormones	hormone	NNS	NNS	_	19	nmod	_	_
24	throughout	throughout	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	vasculature	vasculature	NN	NN	_	10	nmod	_	_
27	.	.	.	.	_	10	punct	_	_

1	Dephosphorylation	dephosphorylation	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	3	case	_	_
3	ZAP-70	zap-70	NN	NN	_	1	nmod	_	_
4	and	and	CC	CC	_	1	cc	_	_
5	inhibition	inhibition	NN	NN	_	9	compound	_	_
6	of	of	IN	IN	_	9	amod	_	_
7	T	t	NN	NN	_	9	compound	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	activation	activation	NN	NN	_	1	conj	_	_
10	by	by	IN	IN	_	12	case	_	_
11	activated	activate	VBN	VBN	_	12	amod	_	_
12	SHP1	shp1	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	1	punct	_	_

1	Studies	study	NNS	NNS	_	14	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	motheaten	motheaten	NN	NN	_	4	compound	_	_
4	mice	mouse	NNS	NNS	_	1	nmod	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	7	nsubj	_	_
7	lack	lack	VBP	VBP	_	4	acl:relcl	_	_
8	the	the	DT	DT	_	12	det	_	_
9	SHP1	shp1	NN	NN	_	12	compound	_	_
10	protein	protein	NN	NN	_	12	compound	_	_
11	tyrosine	tyrosine	NN	NN	_	12	compound	_	_
12	phosphatase	phosphatase	NN	NN	_	7	dobj	_	_
13	,	,	,	,	_	1	punct	_	_
14	indicate	indicate	VBP	VBP	_	0	root	_	_
15	that	that	IN	IN	_	18	mark	_	_
16	this	this	DT	DT	_	17	det	_	_
17	enzyme	enzyme	NN	NN	_	18	nsubj	_	_
18	plays	play	VBZ	VBZ	_	14	ccomp	_	_
19	an	a	DT	DT	_	22	det	_	_
20	important	important	JJ	JJ	_	22	amod	_	_
21	negative	negative	JJ	JJ	_	22	amod	_	_
22	role	role	NN	NN	_	18	dobj	_	_
23	in	in	IN	IN	_	31	case	_	_
24	T	t	NN	NN	_	31	compound	_	_
25	cell	cell	NN	NN	_	31	compound	_	_
26	antigen	antigen	NN	NN	_	31	compound	_	_
27	receptor	receptor	NN	NN	_	31	compound	_	_
28	(	(	-LRB-	-LRB-	_	31	punct	_	_
29	TCR	tcr	NN	NN	_	31	compound	_	_
30	)	)	-RRB-	-RRB-	_	31	punct	_	_
31	signaling	signaling	NN	NN	_	18	nmod	_	_
32	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	physiological	physiological	JJ	JJ	_	3	amod	_	_
3	substrates	substrate	NNS	NNS	_	13	nsubj	_	_
4	for	for	IN	IN	_	5	case	_	_
5	SHP1	shp1	NN	NN	_	3	nmod	_	_
6	in	in	IN	IN	_	8	case	_	_
7	T	t	NN	NN	_	8	compound	_	_
8	lymphocytes	lymphocyte	NNS	NNS	_	5	nmod	_	_
9	,	,	,	,	_	13	punct	_	_
10	however	however	RB	RB	_	13	advmod	_	_
11	,	,	,	,	_	13	punct	_	_
12	have	have	VBP	VBP	_	13	aux	_	_
13	remained	remain	VBN	VBN	_	0	root	_	_
14	unclear	unclear	JJ	JJ	_	13	xcomp	_	_
15	or	or	CC	CC	_	14	cc	_	_
16	controversial	controversial	JJ	JJ	_	14	conj	_	_
17	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	define	define	VB	VB	_	9	dep	_	_
3	these	these	DT	DT	_	4	det	_	_
4	targets	target	NNS	NNS	_	2	dobj	_	_
5	for	for	IN	IN	_	6	case	_	_
6	SHP1	shp1	NN	NN	_	4	nmod	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	have	have	VBP	VBP	_	9	aux	_	_
9	compared	compare	VBN	VBN	_	0	root	_	_
10	the	the	DT	DT	_	11	det	_	_
11	effects	effect	NNS	NNS	_	9	dobj	_	_
12	of	of	IN	IN	_	14	case	_	_
13	constitutively	constitutively	RB	RB	_	14	advmod	_	_
14	active	active	JJ	JJ	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	inactive	inactive	JJ	JJ	_	14	conj	_	_
17	mutants	mutant	NNS	NNS	_	14	dep	_	_
18	of	of	IN	IN	_	19	case	_	_
19	SHP1	shp1	NN	NN	_	14	nmod	_	_
20	on	on	IN	IN	_	22	case	_	_
21	TCR	tcr	NN	NN	_	22	compound	_	_
22	signaling	signaling	NN	NN	_	11	nmod	_	_
23	.	.	.	.	_	9	punct	_	_

1	Expression	expression	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	wild-type	wild-type	JJ	JJ	_	4	amod	_	_
4	SHP1	shp1	NN	NN	_	1	nmod	_	_
5	had	have	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	9	det	_	_
7	very	very	RB	RB	_	9	advmod	_	_
8	small	small	JJ	JJ	_	9	amod	_	_
9	effect	effect	NN	NN	_	5	dobj	_	_
10	on	on	IN	IN	_	14	case	_	_
11	the	the	DT	DT	_	14	det	_	_
12	TCR-induced	tcr-induced	JJ	JJ	_	14	amod	_	_
13	tyrosine	tyrosine	NN	NN	_	14	compound	_	_
14	phosphorylation	phosphorylation	NN	NN	_	5	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	ZAP-70	zap-70	NN	NN	_	14	nmod	_	_
17	and	and	CC	CC	_	16	cc	_	_
18	Syk	syk	NN	NN	_	16	conj	_	_
19	,	,	,	,	_	5	punct	_	_
20	even	even	RB	RB	_	21	advmod	_	_
21	when	when	WRB	WRB	_	24	advmod	_	_
22	SHP1	shp1	NN	NN	_	24	nsubjpass	_	_
23	was	be	VBD	VBD	_	24	auxpass	_	_
24	overexpressed	overexpress	VBN	VBN	_	5	advcl	_	_
25	20-100-fold	20-100-fold	RB	RB	_	24	nmod	_	_
26	over	over	IN	IN	_	28	case	_	_
27	endogenous	endogenous	JJ	JJ	_	28	amod	_	_
28	SHP1	shp1	NN	NN	_	25	nmod	_	_
29	.	.	.	.	_	5	punct	_	_

1	Inactive	inactive	JJ	JJ	_	2	amod	_	_
2	SHP1-D421A	shp1-d421a	NN	NN	_	8	nsubj	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	wild-type	wild-type	JJ	JJ	_	5	amod	_	_
5	SHP2	shp2	NN	NN	_	2	conj	_	_
6	were	be	VBD	VBD	_	8	cop	_	_
7	without	without	IN	IN	_	8	case	_	_
8	effects	effect	NNS	NNS	_	0	root	_	_
9	.	.	.	.	_	8	punct	_	_

1	Constitutively	constitutively	RB	RB	_	3	advmod	_	_
2	active	active	JJ	JJ	_	3	amod	_	_
3	SHP1-DeltaSH2	shp1-deltash2	NN	NN	_	4	nsubj	_	_
4	had	have	VBD	VBD	_	0	root	_	_
5	a	a	DT	DT	_	8	det	_	_
6	more	more	RBR	RBR	_	8	advmod	_	_
7	pronounced	pronounced	JJ	JJ	_	8	amod	_	_
8	effect	effect	NN	NN	_	4	dobj	_	_
9	on	on	IN	IN	_	10	case	_	_
10	ZAP-70	zap-70	NN	NN	_	4	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Syk	syk	NN	NN	_	10	conj	_	_
13	,	,	,	,	_	4	punct	_	_
14	even	even	RB	RB	_	15	advmod	_	_
15	when	when	WRB	WRB	_	16	advmod	_	_
16	expressed	express	VBN	VBN	_	4	advcl	_	_
17	at	at	IN	IN	_	20	case	_	_
18	near	near	JJ	JJ	_	20	amod	_	_
19	physiological	physiological	JJ	JJ	_	20	amod	_	_
20	levels	level	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	4	punct	_	_

1	SHP1-DeltaSH2	shp1-deltash2	NN	NN	_	3	nsubj	_	_
2	also	also	RB	RB	_	3	advmod	_	_
3	inhibited	inhibit	VBD	VBD	_	0	root	_	_
4	events	event	NNS	NNS	_	3	dobj	_	_
5	downstream	downstream	JJ	JJ	_	3	advmod	_	_
6	of	of	IN	IN	_	7	case	_	_
7	ZAP-70	zap-70	NN	NN	_	5	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	Syk	syk	NN	NN	_	7	conj	_	_
10	,	,	,	,	_	3	punct	_	_
11	such	such	JJ	JJ	_	13	case	_	_
12	as	as	IN	IN	_	11	mwe	_	_
13	activation	activation	NN	NN	_	3	nmod	_	_
14	of	of	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	mitogen-activated	mitogen-activated	JJ	JJ	_	19	amod	_	_
17	protein	protein	NN	NN	_	19	compound	_	_
18	kinase	kinase	NN	NN	_	19	compound	_	_
19	Erk2	erk2	NN	NN	_	13	nmod	_	_
20	and	and	CC	CC	_	13	cc	_	_
21	the	the	DT	DT	_	23	det	_	_
22	transcriptional	transcriptional	JJ	JJ	_	23	amod	_	_
23	activation	activation	NN	NN	_	13	conj	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	interleukin-2	interleukin-2	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	8	nmod	_	_
3	,	,	,	,	_	8	punct	_	_
4	a	a	DT	DT	_	7	det	_	_
5	constitutively	constitutively	RB	RB	_	6	advmod	_	_
6	active	active	JJ	JJ	_	7	amod	_	_
7	SHP2-DeltaSH2	shp2-deltash2	NN	NN	_	8	nsubj	_	_
8	had	have	VBD	VBD	_	0	root	_	_
9	no	no	DT	DT	_	12	neg	_	_
10	statistically	statistically	RB	RB	_	12	advmod	_	_
11	significant	significant	JJ	JJ	_	12	amod	_	_
12	effect	effect	NN	NN	_	8	dobj	_	_
13	(	(	-LRB-	-LRB-	_	16	punct	_	_
14	although	although	IN	IN	_	16	mark	_	_
15	it	it	PRP	PRP	_	16	nsubj	_	_
16	caused	cause	VBD	VBD	_	8	parataxis	_	_
17	a	a	DT	DT	_	19	det	_	_
18	slight	slight	JJ	JJ	_	19	amod	_	_
19	augmentation	augmentation	NN	NN	_	16	dobj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	some	some	DT	DT	_	23	det	_	_
22	individual	individual	JJ	JJ	_	23	amod	_	_
23	experiments	experiment	NNS	NNS	_	16	nmod	_	_
24	)	)	-RRB-	-RRB-	_	16	punct	_	_
25	.	.	.	.	_	8	punct	_	_

1	None	none	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	the	the	DT	DT	_	4	det	_	_
4	constructs	construct	NNS	NNS	_	1	nmod	_	_
5	influenced	influence	VBD	VBD	_	0	root	_	_
6	the	the	DT	DT	_	9	det	_	_
7	anti-CD3-induced	anti-cd3-induced	JJ	JJ	_	9	amod	_	_
8	tyrosine	tyrosine	NN	NN	_	9	compound	_	_
9	phosphorylation	phosphorylation	NN	NN	_	5	dobj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	the	the	DT	DT	_	13	dep	_	_
12	TCR	tcr	NN	NN	_	13	compound	_	_
13	zeta-chain	zeta-chain	NN	NN	_	9	nmod	_	_
14	or	or	CC	CC	_	13	cc	_	_
15	phospholipase	phospholipase	NN	NN	_	16	compound	_	_
16	Cgamma1	cgamma1	NN	NN	_	13	conj	_	_
17	,	,	,	,	_	5	punct	_	_
18	indicating	indicate	VBG	VBG	_	5	advcl	_	_
19	that	that	IN	IN	_	25	mark	_	_
20	Src	src	NN	NN	_	23	compound	_	_
21	family	family	NN	NN	_	23	compound	_	_
22	kinase	kinase	NN	NN	_	23	compound	_	_
23	function	function	NN	NN	_	25	nsubj	_	_
24	was	be	VBD	VBD	_	25	cop	_	_
25	intact	intact	JJ	JJ	_	18	ccomp	_	_
26	.	.	.	.	_	5	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	support	support	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	notion	notion	NN	NN	_	6	dobj	_	_
9	that	that	IN	IN	_	16	mark	_	_
10	ZAP-70	zap-70	NN	NN	_	16	nsubj	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Syk	syk	NN	NN	_	10	conj	_	_
13	can	can	MD	MD	_	16	aux	_	_
14	be	be	VB	VB	_	16	cop	_	_
15	direct	direct	JJ	JJ	_	16	amod	_	_
16	substrates	substrate	NNS	NNS	_	8	dep	_	_
17	for	for	IN	IN	_	18	case	_	_
18	SHP1	shp1	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	21	case	_	_
20	intact	intact	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	.	.	.	.	_	6	punct	_	_

1	However	however	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	two	two	CD	CD	_	6	nummod	_	_
5	SH2	sh2	NN	NN	_	6	compound	_	_
6	domains	domain	NNS	NNS	_	11	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	SHP1	shp1	NN	NN	_	6	nmod	_	_
9	did	do	VBD	VBD	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	facilitate	facilitate	VB	VB	_	0	root	_	_
12	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
13	recognition	recognition	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	15	case	_	_
15	ZAP-70	zap-70	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	Syk	syk	NN	NN	_	15	conj	_	_
18	as	as	IN	IN	_	19	case	_	_
19	substrates	substrate	NNS	NNS	_	13	nmod	_	_
20	in	in	IN	IN	_	22	case	_	_
21	intact	intact	JJ	JJ	_	22	amod	_	_
22	cells	cell	NNS	NNS	_	11	nmod	_	_
23	.	.	.	.	_	11	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	SHP1	shp1	NN	NN	_	10	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	10	auxpass	_	_
8	not	not	RB	RB	_	10	neg	_	_
9	actively	actively	RB	RB	_	10	advmod	_	_
10	recruited	recruit	VBN	VBN	_	4	ccomp	_	_
11	to	to	TO	TO	_	12	mark	_	_
12	inhibit	inhibit	VB	VB	_	10	xcomp	_	_
13	TCR	tcr	NN	NN	_	14	compound	_	_
14	signaling	signaling	NN	NN	_	12	dobj	_	_
15	induced	induce	VBN	VBN	_	14	acl	_	_
16	by	by	IN	IN	_	17	case	_	_
17	ligation	ligation	NN	NN	_	15	nmod	_	_
18	of	of	IN	IN	_	20	case	_	_
19	this	this	DT	DT	_	20	det	_	_
20	receptor	receptor	NN	NN	_	17	nmod	_	_
21	alone	alone	RB	RB	_	20	advmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Instead	instead	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	propose	propose	VBP	VBP	_	0	root	_	_
5	that	that	IN	IN	_	12	mark	_	_
6	ligation	ligation	NN	NN	_	12	nsubj	_	_
7	of	of	IN	IN	_	11	case	_	_
8	a	a	DT	DT	_	11	det	_	_
9	distinct	distinct	JJ	JJ	_	11	amod	_	_
10	inhibitory	inhibitory	JJ	JJ	_	11	amod	_	_
11	receptor	receptor	NN	NN	_	6	nmod	_	_
12	leads	lead	VBZ	VBZ	_	4	ccomp	_	_
13	to	to	TO	TO	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	recruitment	recruitment	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	17	case	_	_
17	SHP1	shp1	NN	NN	_	15	nmod	_	_
18	via	via	IN	IN	_	21	case	_	_
19	its	its	PRP$	PRP$	_	21	nmod:poss	_	_
20	SH2	sh2	NN	NN	_	21	compound	_	_
21	domains	domain	NNS	NNS	_	15	nmod	_	_
22	,	,	,	,	_	15	punct	_	_
23	activation	activation	NN	NN	_	15	conj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	SHP1	shp1	NN	NN	_	23	nmod	_	_
26	and	and	CC	CC	_	15	cc	_	_
27	subsequently	subsequently	RB	RB	_	28	advmod	_	_
28	inhibition	inhibition	NN	NN	_	15	conj	_	_
29	of	of	IN	IN	_	31	case	_	_
30	TCR	tcr	NN	NN	_	31	compound	_	_
31	signals	signal	NNS	NNS	_	28	nmod	_	_
32	if	if	IN	IN	_	37	mark	_	_
33	the	the	DT	DT	_	35	det	_	_
34	inhibitory	inhibitory	JJ	JJ	_	35	amod	_	_
35	receptor	receptor	NN	NN	_	37	nsubjpass	_	_
36	is	be	VBZ	VBZ	_	37	auxpass	_	_
37	juxtaposed	juxtapose	VBN	VBN	_	12	advcl	_	_
38	to	to	TO	TO	_	40	case	_	_
39	the	the	DT	DT	_	40	det	_	_
40	TCR	tcr	NN	NN	_	37	nmod	_	_
41	.	.	.	.	_	4	punct	_	_

1	Classification	classification	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	5	case	_	_
3	IVS1-10T	ivs1-10t	NN	NN	_	5	compound	_	_
4	--&gt;	--&gt;	TO	TO	_	5	dep	_	_
5	C	c	NN	NN	_	1	nmod	_	_
6	as	as	IN	IN	_	8	case	_	_
7	a	a	DT	DT	_	8	det	_	_
8	polymorphism	polymorphism	NN	NN	_	1	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	BRCA1	brca1	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	Mutations	mutation	NNS	NNS	_	10	nsubj	_	_
2	inactivating	inactivate	VBG	VBG	_	1	acl	_	_
3	the	the	DT	DT	_	7	det	_	_
4	tumor	tumor	NN	NN	_	7	compound	_	_
5	suppressor	suppressor	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	BRCA1	brca1	NN	NN	_	2	dobj	_	_
8	may	may	MD	MD	_	10	aux	_	_
9	be	be	VB	VB	_	10	cop	_	_
10	responsible	responsible	JJ	JJ	_	0	root	_	_
11	for	for	IN	IN	_	12	case	_	_
12	disease	disease	NN	NN	_	10	nmod	_	_
13	for	for	IN	IN	_	17	case	_	_
14	up	up	RB	RB	_	16	advmod	_	_
15	to	to	TO	TO	_	16	dep	_	_
16	80	80	CD	CD	_	17	nummod	_	_
17	%	%	NN	NN	_	10	nmod	_	_
18	of	of	IN	IN	_	22	case	_	_
19	familial	familial	JJ	JJ	_	22	amod	_	_
20	ovarian	ovarian	JJ	JJ	_	22	amod	_	_
21	cancer	cancer	NN	NN	_	22	compound	_	_
22	cases	case	NNS	NNS	_	17	nmod	_	_
23	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	syndrome	syndrome	NN	NN	_	7	nmod	_	_
4	,	,	,	,	_	7	punct	_	_
5	tumorigenesis	tumorigenesis	NN	NN	_	7	nsubj	_	_
6	classically	classically	RB	RB	_	7	advmod	_	_
7	initiates	initiate	VBZ	VBZ	_	0	root	_	_
8	from	from	IN	IN	_	11	case	_	_
9	an	a	DT	DT	_	11	det	_	_
10	inherited	inherit	VBN	VBN	_	11	amod	_	_
11	mutation	mutation	NN	NN	_	7	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	one	one	CD	CD	_	14	nummod	_	_
14	allele	allele	NN	NN	_	7	nmod	_	_
15	followed	follow	VBN	VBN	_	7	dep	_	_
16	by	by	IN	IN	_	18	case	_	_
17	somatic	somatic	JJ	JJ	_	18	amod	_	_
18	deletion	deletion	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	22	case	_	_
20	the	the	DT	DT	_	22	det	_	_
21	normal	normal	JJ	JJ	_	22	amod	_	_
22	allele	allele	NN	NN	_	18	nmod	_	_
23	.	.	.	.	_	7	punct	_	_

1	Sequencing	sequencing	NN	NN	_	21	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	BRCA1	brca1	NN	NN	_	1	nmod	_	_
4	amplified	amplify	VBN	VBN	_	3	acl	_	_
5	from	from	IN	IN	_	7	case	_	_
6	genomic	genomic	JJ	JJ	_	7	amod	_	_
7	DNA	dna	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	lymphocytes	lymphocyte	NNS	NNS	_	7	nmod	_	_
10	and	and	CC	CC	_	9	cc	_	_
11	microdissected	microdissect	VBN	VBN	_	14	amod	_	_
12	ovarian	ovarian	JJ	JJ	_	14	amod	_	_
13	tumor	tumor	NN	NN	_	14	compound	_	_
14	cells	cell	NNS	NNS	_	9	conj	_	_
15	of	of	IN	IN	_	20	case	_	_
16	a	a	DT	DT	_	20	det	_	_
17	familial	familial	JJ	JJ	_	20	amod	_	_
18	ovarian	ovarian	JJ	JJ	_	20	amod	_	_
19	cancer	cancer	NN	NN	_	20	compound	_	_
20	patient	patient	NN	NN	_	9	nmod	_	_
21	revealed	reveal	VBD	VBD	_	0	root	_	_
22	three	three	CD	CD	_	27	nummod	_	_
23	,	,	,	,	_	27	punct	_	_
24	rare	rare	JJ	JJ	_	27	amod	_	_
25	heterozygous	heterozygous	NN	NN	_	27	compound	_	_
26	DNA	dna	NN	NN	_	27	compound	_	_
27	variations	variation	NNS	NNS	_	21	dobj	_	_
28	(	(	-LRB-	-LRB-	_	29	punct	_	_
29	2418delA	2418dela	NN	NN	_	27	dep	_	_
30	,	,	,	,	_	29	punct	_	_
31	233G	233g	NN	NN	_	33	compound	_	_
32	--&gt;	--&gt;	TO	TO	_	33	dep	_	_
33	A	a	NN	NN	_	29	conj	_	_
34	,	,	,	,	_	29	punct	_	_
35	and	and	CC	CC	_	29	cc	_	_
36	IVS1-10T	ivs1-10t	NN	NN	_	38	compound	_	_
37	--&gt;	--&gt;	TO	TO	_	38	dep	_	_
38	C	c	NN	NN	_	29	conj	_	_
39	)	)	-RRB-	-RRB-	_	29	punct	_	_
40	in	in	IN	IN	_	42	case	_	_
41	both	both	CC	CC	_	42	cc:preconj	_	_
42	tumor	tumor	NN	NN	_	21	nmod	_	_
43	and	and	CC	CC	_	42	cc	_	_
44	constitutional	constitutional	JJ	JJ	_	46	amod	_	_
45	(	(	-LRB-	-LRB-	_	46	punct	_	_
46	lymphocyte	lymphocyte	NN	NN	_	42	conj	_	_
47	)	)	-RRB-	-RRB-	_	46	punct	_	_
48	DNA	dna	NN	NN	_	42	dep	_	_
49	.	.	.	.	_	21	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	both	both	DT	DT	_	4	det	_	_
4	copies	copy	NNS	NNS	_	8	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	BRCA1	brca1	NN	NN	_	4	nmod	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	retained	retain	VBN	VBN	_	0	root	_	_
9	in	in	IN	IN	_	10	case	_	_
10	tumor	tumor	NN	NN	_	8	nmod	_	_
11	.	.	.	.	_	8	punct	_	_

1	Haplotype	haplotype	NN	NN	_	2	compound	_	_
2	analysis	analysis	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	the	the	DT	DT	_	5	dep	_	_
5	patient	patient	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	four	four	CD	CD	_	8	nummod	_	_
8	siblings	sibling	NNS	NNS	_	5	conj	_	_
9	assigned	assign	VBD	VBD	_	0	root	_	_
10	2418delA	2418dela	NN	NN	_	9	dobj	_	_
11	to	to	TO	TO	_	13	case	_	_
12	one	one	CD	CD	_	13	nummod	_	_
13	copy	copy	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	BRCA1	brca1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	9	cc	_	_
17	233G	233g	NN	NN	_	19	compound	_	_
18	--&gt;	--&gt;	TO	TO	_	19	dep	_	_
19	A	a	NN	NN	_	9	conj	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	IVS1-10T	ivs1-10t	NN	NN	_	23	compound	_	_
22	--&gt;	--&gt;	TO	TO	_	23	dep	_	_
23	C	c	NN	NN	_	19	conj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	other	other	JJ	JJ	_	9	nmod	_	_
27	.	.	.	.	_	9	punct	_	_

1	The	the	DT	DT	_	5	det	_	_
2	DNA	dna	NN	NN	_	5	compound	_	_
3	change	change	NN	NN	_	5	compound	_	_
4	,	,	,	,	_	5	punct	_	_
5	2418delA	2418dela	NN	NN	_	8	nsubjpass	_	_
6	,	,	,	,	_	5	punct	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	considered	consider	VBN	VBN	_	0	root	_	_
9	a	a	DT	DT	_	10	det	_	_
10	mutation	mutation	NN	NN	_	8	xcomp	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	inactivated	inactivate	VBD	VBD	_	10	acl:relcl	_	_
13	one	one	CD	CD	_	15	nummod	_	_
14	BRCA1	brca1	NN	NN	_	15	compound	_	_
15	allele	allele	NN	NN	_	12	dobj	_	_
16	because	because	IN	IN	_	18	mark	_	_
17	it	it	PRP	PRP	_	18	nsubj	_	_
18	caused	cause	VBD	VBD	_	8	advcl	_	_
19	a	a	DT	DT	_	20	det	_	_
20	frameshift	frameshift	NN	NN	_	18	dobj	_	_
21	and	and	CC	CC	_	20	cc	_	_
22	generation	generation	NN	NN	_	20	conj	_	_
23	of	of	IN	IN	_	27	case	_	_
24	a	a	DT	DT	_	27	det	_	_
25	premature	premature	JJ	JJ	_	27	amod	_	_
26	stop	stop	NN	NN	_	27	compound	_	_
27	codon	codon	NN	NN	_	22	nmod	_	_
28	,	,	,	,	_	20	punct	_	_
29	resulting	result	VBG	VBG	_	20	acl	_	_
30	in	in	IN	IN	_	31	case	_	_
31	synthesis	synthesis	NN	NN	_	29	nmod	_	_
32	of	of	IN	IN	_	35	case	_	_
33	a	a	DT	DT	_	35	det	_	_
34	truncated	truncate	VBN	VBN	_	35	amod	_	_
35	peptide	peptide	NN	NN	_	31	nmod	_	_
36	as	as	IN	IN	_	37	mark	_	_
37	evidenced	evidence	VBN	VBN	_	29	advcl	_	_
38	by	by	IN	IN	_	44	case	_	_
39	an	a	DT	DT	_	44	det	_	_
40	in	in	FW	FW	_	44	amod	_	_
41	vitro	vitro	FW	FW	_	40	dep	_	_
42	protein	protein	NN	NN	_	44	compound	_	_
43	truncation	truncation	NN	NN	_	44	compound	_	_
44	test	test	NN	NN	_	37	nmod	_	_
45	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	DNA	dna	NN	NN	_	7	compound	_	_
3	variation	variation	NN	NN	_	7	compound	_	_
4	,	,	,	,	_	7	punct	_	_
5	233G	233g	NN	NN	_	7	dep	_	_
6	--&gt;	--&gt;	TO	TO	_	7	dep	_	_
7	A	a	NN	NN	_	11	nsubj	_	_
8	,	,	,	,	_	11	punct	_	_
9	does	do	VBZ	VBZ	_	11	aux	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	result	result	VB	VB	_	0	root	_	_
12	in	in	IN	IN	_	16	case	_	_
13	an	a	DT	DT	_	16	det	_	_
14	amino	amino	NN	NN	_	16	compound	_	_
15	acid	acid	NN	NN	_	16	compound	_	_
16	change	change	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	11	punct	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	considered	consider	VBN	VBN	_	11	conj	_	_
21	a	a	DT	DT	_	23	det	_	_
22	benign	benign	JJ	JJ	_	23	amod	_	_
23	polymorphism	polymorphism	NN	NN	_	20	xcomp	_	_
24	.	.	.	.	_	11	punct	_	_

1	IVS1-10T	ivs1-10t	NN	NN	_	3	compound	_	_
2	--&gt;	--&gt;	TO	TO	_	3	dep	_	_
3	C	c	NN	NN	_	8	nsubj	_	_
4	is	be	VBZ	VBZ	_	8	cop	_	_
5	a	a	DT	DT	_	8	det	_	_
6	unique	unique	JJ	JJ	_	8	amod	_	_
7	BRCA1	brca1	NN	NN	_	8	compound	_	_
8	change	change	NN	NN	_	0	root	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	occurs	occur	VBZ	VBZ	_	8	acl:relcl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	last	last	JJ	JJ	_	14	amod	_	_
14	nucleotide	nucleotide	NN	NN	_	10	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	a	a	DT	DT	_	18	det	_	_
17	consensus	consensus	NN	NN	_	18	compound	_	_
18	sequence	sequence	NN	NN	_	14	nmod	_	_
19	for	for	IN	IN	_	22	case	_	_
20	a	a	DT	DT	_	22	det	_	_
21	branch	branch	NN	NN	_	22	compound	_	_
22	site	site	NN	NN	_	18	nmod	_	_
23	critical	critical	JJ	JJ	_	22	amod	_	_
24	for	for	IN	IN	_	26	case	_	_
25	RNA	rna	NN	NN	_	26	compound	_	_
26	splicing	splicing	NN	NN	_	23	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	Therefore	therefore	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	investigated	investigate	VBD	VBD	_	0	root	_	_
5	whether	whether	IN	IN	_	10	mark	_	_
6	IVS1-10T	ivs1-10t	NN	NN	_	8	compound	_	_
7	--&gt;	--&gt;	TO	TO	_	8	dep	_	_
8	C	c	NN	NN	_	10	nsubj	_	_
9	deleteriously	deleteriously	RB	RB	_	10	advmod	_	_
10	affected	affect	VBD	VBD	_	4	ccomp	_	_
11	BRCA1	brca1	NN	NN	_	10	dobj	_	_
12	splicing	splicing	NN	NN	_	11	dep	_	_
13	or	or	CC	CC	_	12	cc	_	_
14	expression	expression	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	thereby	thereby	RB	RB	_	18	advmod	_	_
18	inactivated	inactivate	VBD	VBD	_	10	conj	_	_
19	the	the	DT	DT	_	22	det	_	_
20	other	other	JJ	JJ	_	22	amod	_	_
21	BRCA1	brca1	NN	NN	_	22	compound	_	_
22	allele	allele	NN	NN	_	18	dobj	_	_
23	.	.	.	.	_	4	punct	_	_

1	Using	use	VBG	VBG	_	29	advcl	_	_
2	the	the	DT	DT	_	3	det	_	_
3	technique	technique	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	8	case	_	_
5	reverse	reverse	JJ	JJ	_	8	amod	_	_
6	transcription-polymerase	transcription-polymerase	JJ	JJ	_	8	amod	_	_
7	chain	chain	NN	NN	_	8	compound	_	_
8	reaction	reaction	NN	NN	_	3	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PCR	pcr	NN	NN	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	with	with	IN	IN	_	13	case	_	_
13	RNA	rna	NN	NN	_	1	nmod	_	_
14	isolated	isolate	VBN	VBN	_	13	acl	_	_
15	from	from	IN	IN	_	18	case	_	_
16	lymphoid	lymphoid	JJ	JJ	_	18	amod	_	_
17	cell	cell	NN	NN	_	18	compound	_	_
18	lines	line	NNS	NNS	_	14	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	patient	patient	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	of	of	IN	IN	_	24	case	_	_
24	controls	control	NNS	NNS	_	21	conj	_	_
25	,	,	,	,	_	29	punct	_	_
26	no	no	DT	DT	_	27	neg	_	_
27	evidence	evidence	NN	NN	_	29	nsubjpass	_	_
28	was	be	VBD	VBD	_	29	auxpass	_	_
29	found	find	VBN	VBN	_	0	root	_	_
30	that	that	IN	IN	_	33	mark	_	_
31	IVS1-10TC	ivs1-10tc	NN	NN	_	33	nsubj	_	_
32	abnormally	abnormally	RB	RB	_	33	advmod	_	_
33	disrupted	disrupt	VBD	VBD	_	29	ccomp	_	_
34	mRNA	mrna	NN	NN	_	35	compound	_	_
35	splicing	splicing	NN	NN	_	33	dobj	_	_
36	or	or	CC	CC	_	33	cc	_	_
37	caused	cause	VBD	VBD	_	33	conj	_	_
38	the	the	DT	DT	_	39	det	_	_
39	absence	absence	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	42	case	_	_
41	BRCA1	brca1	NN	NN	_	42	compound	_	_
42	mRNA	mrna	NN	NN	_	39	nmod	_	_
43	.	.	.	.	_	29	punct	_	_

1	Thus	thus	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	IVS1-10T	ivs1-10t	NN	NN	_	5	compound	_	_
4	--&gt;	--&gt;	TO	TO	_	5	dep	_	_
5	C	c	NN	NN	_	8	nsubj	_	_
6	is	be	VBZ	VBZ	_	8	cop	_	_
7	not	not	RB	RB	_	8	neg	_	_
8	harmful	harmful	JJ	JJ	_	0	root	_	_
9	to	to	TO	TO	_	11	case	_	_
10	BRCA1	brca1	NN	NN	_	11	compound	_	_
11	function	function	NN	NN	_	8	nmod	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	is	be	VBZ	VBZ	_	15	auxpass	_	_
15	classified	classify	VBN	VBN	_	8	conj	_	_
16	a	a	DT	DT	_	18	det	_	_
17	benign	benign	JJ	JJ	_	18	amod	_	_
18	polymorphism	polymorphism	NN	NN	_	15	xcomp	_	_
19	.	.	.	.	_	8	punct	_	_

1	Retention	retention	NN	NN	_	19	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	normal	normal	JJ	JJ	_	6	amod	_	_
5	BRCA1	brca1	NN	NN	_	6	compound	_	_
6	allele	allele	NN	NN	_	1	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	tumor	tumor	NN	NN	_	1	nmod	_	_
10	with	with	IN	IN	_	17	case	_	_
11	the	the	DT	DT	_	17	det	_	_
12	heterozygous	heterozygous	JJ	JJ	_	17	amod	_	_
13	germline	germline	NN	NN	_	17	compound	_	_
14	BRCA1	brca1	NN	NN	_	17	compound	_	_
15	mutation	mutation	NN	NN	_	17	compound	_	_
16	,	,	,	,	_	17	punct	_	_
17	2418delA	2418dela	NN	NN	_	9	nmod	_	_
18	,	,	,	,	_	19	punct	_	_
19	indicated	indicate	VBD	VBD	_	0	root	_	_
20	that	that	IN	IN	_	29	mark	_	_
21	mutational	mutational	JJ	JJ	_	22	amod	_	_
22	inactivation	inactivation	NN	NN	_	29	nsubjpass	_	_
23	of	of	IN	IN	_	26	case	_	_
24	both	both	DT	DT	_	26	det	_	_
25	BRCA1	brca1	NN	NN	_	26	compound	_	_
26	alleles	allele	NNS	NNS	_	22	nmod	_	_
27	was	be	VBD	VBD	_	29	auxpass	_	_
28	not	not	RB	RB	_	29	neg	_	_
29	required	require	VBN	VBN	_	19	ccomp	_	_
30	for	for	IN	IN	_	31	case	_	_
31	tumorigenesis	tumorigenesis	NN	NN	_	29	nmod	_	_
32	.	.	.	.	_	19	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	possible	possible	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	7	det	_	_
6	normal	normal	JJ	JJ	_	7	amod	_	_
7	allele	allele	NN	NN	_	11	nsubjpass	_	_
8	may	may	MD	MD	_	11	aux	_	_
9	be	be	VB	VB	_	11	auxpass	_	_
10	functionally	functionally	RB	RB	_	11	advmod	_	_
11	inactivated	inactivate	VBN	VBN	_	3	ccomp	_	_
12	by	by	IN	IN	_	15	case	_	_
13	a	a	DT	DT	_	15	det	_	_
14	nonmutational	nonmutational	JJ	JJ	_	15	amod	_	_
15	mechanism	mechanism	NN	NN	_	11	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	Human	human	JJ	JJ	_	7	amod	_	_
2	T-cell	t-cell	NN	NN	_	7	compound	_	_
3	lymphotrophic	lymphotrophic	JJ	JJ	_	7	amod	_	_
4	virus	virus	NN	NN	_	7	compound	_	_
5	type-I	type-i	JJ	JJ	_	7	amod	_	_
6	tax	tax	NN	NN	_	7	compound	_	_
7	gene	gene	NN	NN	_	8	nsubj	_	_
8	induces	induce	VBZ	VBZ	_	0	root	_	_
9	secretion	secretion	NN	NN	_	8	dobj	_	_
10	of	of	IN	IN	_	14	case	_	_
11	human	human	JJ	JJ	_	14	amod	_	_
12	macrophage	macrophage	NN	NN	_	14	compound	_	_
13	inflammatory	inflammatory	JJ	JJ	_	14	amod	_	_
14	protein-1alpha	protein-1alpha	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	8	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	lymphotropic	lymphotropic	JJ	JJ	_	5	amod	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	I	i	NN	NN	_	9	nsubj	_	_
6	(	(	-LRB-	-LRB-	_	7	punct	_	_
7	HTLV-I	htlv-i	NN	NN	_	5	appos	_	_
8	)	)	-RRB-	-RRB-	_	7	punct	_	_
9	encodes	encode	VBZ	VBZ	_	0	root	_	_
10	for	for	IN	IN	_	15	case	_	_
11	a	a	DT	DT	_	15	det	_	_
12	40-kDa	40-kda	JJ	JJ	_	15	amod	_	_
13	protein	protein	NN	NN	_	15	compound	_	_
14	,	,	,	,	_	15	punct	_	_
15	Tax	tax	NN	NN	_	9	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	is	be	VBZ	VBZ	_	19	cop	_	_
19	important	important	JJ	JJ	_	15	acl:relcl	_	_
20	for	for	IN	IN	_	22	case	_	_
21	the	the	DT	DT	_	22	det	_	_
22	immortalization	immortalization	NN	NN	_	19	nmod	_	_
23	of	of	IN	IN	_	25	case	_	_
24	T	t	NN	NN	_	25	compound	_	_
25	cells	cell	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	9	punct	_	_

1	Tax	tax	NN	NN	_	4	nsubjpass	_	_
2	has	have	VBZ	VBZ	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	6	mark	_	_
6	transactivate	transactivate	VB	VB	_	4	xcomp	_	_
7	several	several	JJ	JJ	_	9	amod	_	_
8	cellular	cellular	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	6	dobj	_	_
10	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	show	show	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	MIP-1alpha	mip-1alpha	NN	NN	_	11	nsubjpass	_	_
9	is	be	VBZ	VBZ	_	11	auxpass	_	_
10	selectively	selectively	RB	RB	_	11	advmod	_	_
11	expressed	express	VBN	VBN	_	6	ccomp	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	secreted	secrete	VBN	VBN	_	11	conj	_	_
14	in	in	IN	IN	_	20	case	_	_
15	the	the	DT	DT	_	20	det	_	_
16	tax	tax	NN	NN	_	20	compound	_	_
17	transfected	transfected	JJ	JJ	_	20	amod	_	_
18	Jurkat	jurkat	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	line	line	NN	NN	_	11	nmod	_	_
21	upon	upon	IN	IN	_	23	case	_	_
22	mitogen	mitogen	NN	NN	_	23	compound	_	_
23	stimulation	stimulation	NN	NN	_	11	nmod	_	_
24	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	8	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	MIP-1alpha-R	mip-1alpha-r	NN	NN	_	4	compound	_	_
4	mRNA	mrna	NN	NN	_	1	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	these	these	DT	DT	_	7	det	_	_
7	cells	cell	NNS	NNS	_	1	nmod	_	_
8	suggests	suggest	VBZ	VBZ	_	0	root	_	_
9	an	a	DT	DT	_	11	det	_	_
10	autocrine	autocrine	JJ	JJ	_	11	amod	_	_
11	role	role	NN	NN	_	8	dobj	_	_
12	for	for	IN	IN	_	14	case	_	_
13	this	this	DT	DT	_	14	det	_	_
14	chemokine	chemokine	NN	NN	_	11	nmod	_	_
15	in	in	IN	IN	_	18	case	_	_
16	HTLV-I	htlv-i	NN	NN	_	18	compound	_	_
17	infected	infected	JJ	JJ	_	18	amod	_	_
18	T-cells	t-cell	NNS	NNS	_	11	nmod	_	_
19	.	.	.	.	_	8	punct	_	_

1	Induced	induce	VBN	VBN	_	2	amod	_	_
2	MIP-1alpha	mip-1alpha	NN	NN	_	12	nsubj	_	_
3	expression	expression	NN	NN	_	2	dep	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	secretion	secretion	NN	NN	_	3	conj	_	_
6	in	in	IN	IN	_	11	case	_	_
7	PMA/PHA	pma/pha	NN	NN	_	11	compound	_	_
8	stimulated	stimulated	JJ	JJ	_	11	amod	_	_
9	tax	tax	NN	NN	_	11	compound	_	_
10	transfected	transfected	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	2	nmod	_	_
12	correlate	correlate	VBP	VBP	_	0	root	_	_
13	with	with	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	noninduction	noninduction	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	MNP-1	mnp-1	NN	NN	_	19	compound	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	which	which	WDT	WDT	_	24	nsubjpass	_	_
22	is	be	VBZ	VBZ	_	24	auxpass	_	_
23	intimately	intimately	RB	RB	_	24	advmod	_	_
24	involved	involve	VBN	VBN	_	19	acl:relcl	_	_
25	in	in	IN	IN	_	26	mark	_	_
26	downmodulating	downmodulate	VBG	VBG	_	24	advcl	_	_
27	the	the	DT	DT	_	29	det	_	_
28	MIP-1alpha	mip-1alpha	NN	NN	_	29	compound	_	_
29	gene	gene	NN	NN	_	26	dobj	_	_
30	.	.	.	.	_	12	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	beta-globin	beta-globin	NN	NN	_	3	compound	_	_
3	promoter	promoter	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	important	important	JJ	JJ	_	0	root	_	_
6	for	for	IN	IN	_	7	case	_	_
7	recruitment	recruitment	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	11	case	_	_
9	erythroid	erythroid	JJ	JJ	_	11	amod	_	_
10	Kruppel-like	kruppel-like	JJ	JJ	_	11	amod	_	_
11	factor	factor	NN	NN	_	7	nmod	_	_
12	to	to	TO	TO	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	locus	locus	NN	NN	_	16	compound	_	_
15	control	control	NN	NN	_	16	compound	_	_
16	region	region	NN	NN	_	7	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	erythroid	erythroid	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	16	nmod	_	_
20	.	.	.	.	_	5	punct	_	_

1	Erythroid	erythroid	JJ	JJ	_	3	amod	_	_
2	Kruppel-like	kruppel-like	JJ	JJ	_	3	amod	_	_
3	factor	factor	NN	NN	_	20	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	EKLF	eklf	NN	NN	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	which	which	WDT	WDT	_	9	nsubj	_	_
9	binds	bind	VBZ	VBZ	_	3	acl:relcl	_	_
10	to	to	TO	TO	_	13	case	_	_
11	the	the	DT	DT	_	13	det	_	_
12	CACCC	caccc	NN	NN	_	13	compound	_	_
13	box	box	NN	NN	_	9	nmod	_	_
14	in	in	IN	IN	_	17	case	_	_
15	the	the	DT	DT	_	17	det	_	_
16	beta-globin	beta-globin	NN	NN	_	17	compound	_	_
17	promoter	promoter	NN	NN	_	13	nmod	_	_
18	,	,	,	,	_	3	punct	_	_
19	is	be	VBZ	VBZ	_	20	auxpass	_	_
20	required	require	VBN	VBN	_	0	root	_	_
21	for	for	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	expression	expression	NN	NN	_	20	nmod	_	_
24	of	of	IN	IN	_	27	case	_	_
25	the	the	DT	DT	_	27	det	_	_
26	beta-globin	beta-globin	NN	NN	_	27	compound	_	_
27	gene	gene	NN	NN	_	23	nmod	_	_
28	in	in	IN	IN	_	31	case	_	_
29	adult	adult	JJ	JJ	_	31	amod	_	_
30	erythroid	erythroid	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	27	nmod	_	_
32	.	.	.	.	_	20	punct	_	_

1	It	it	PRP	PRP	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	9	mark	_	_
6	EKLF	eklf	NN	NN	_	9	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	9	auxpass	_	_
8	also	also	RB	RB	_	9	advmod	_	_
9	required	require	VBN	VBN	_	4	ccomp	_	_
10	for	for	IN	IN	_	12	case	_	_
11	the	the	DT	DT	_	12	det	_	_
12	activity	activity	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	22	case	_	_
14	the	the	DT	DT	_	22	det	_	_
15	beta-globin	beta-globin	NN	NN	_	22	compound	_	_
16	locus	locus	NN	NN	_	22	compound	_	_
17	control	control	NN	NN	_	22	compound	_	_
18	region	region	NN	NN	_	22	compound	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	LCR	lcr	NN	NN	_	22	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	5'HS3	5'hs3	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Some	some	DT	DT	_	2	det	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggests	suggest	VBZ	VBZ	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	LCR	lcr	NN	NN	_	11	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	the	the	DT	DT	_	10	det	_	_
9	beta-globin	beta-globin	NN	NN	_	10	compound	_	_
10	promoter	promoter	NN	NN	_	6	conj	_	_
11	interact	interact	NN	NN	_	3	ccomp	_	_
12	in	in	IN	IN	_	15	case	_	_
13	adult	adult	JJ	JJ	_	15	amod	_	_
14	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	11	nmod	_	_
16	,	,	,	,	_	11	punct	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	the	the	DT	DT	_	19	det	_	_
19	network	network	NN	NN	_	30	nsubj	_	_
20	of	of	IN	IN	_	22	case	_	_
21	protein-protein	protein-protein	JJ	JJ	_	22	amod	_	_
22	interactions	interaction	NNS	NNS	_	19	nmod	_	_
23	that	that	WDT	WDT	_	24	nsubj	_	_
24	exists	exist	VBZ	VBZ	_	19	acl:relcl	_	_
25	between	between	IN	IN	_	28	case	_	_
26	these	these	DT	DT	_	28	det	_	_
27	two	two	CD	CD	_	28	nummod	_	_
28	elements	element	NNS	NNS	_	24	nmod	_	_
29	may	may	MD	MD	_	30	aux	_	_
30	regulate	regulate	VB	VB	_	11	conj	_	_
31	how	how	WRB	WRB	_	34	advmod	_	_
32	EKLF	eklf	NN	NN	_	34	nsubjpass	_	_
33	is	be	VBZ	VBZ	_	34	auxpass	_	_
34	recruited	recruit	VBN	VBN	_	30	ccomp	_	_
35	to	to	TO	TO	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	LCR	lcr	NN	NN	_	34	nmod	_	_
38	.	.	.	.	_	3	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	report	report	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	use	use	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	9	det	_	_
8	PIN*POINT	pin*point	JJ	JJ	_	9	amod	_	_
9	assay	assay	NN	NN	_	6	dobj	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	study	study	VB	VB	_	6	advcl	_	_
12	the	the	DT	DT	_	13	det	_	_
13	role	role	NN	NN	_	11	dobj	_	_
14	of	of	IN	IN	_	16	case	_	_
15	the	the	DT	DT	_	16	det	_	_
16	promoter	promoter	NN	NN	_	13	nmod	_	_
17	on	on	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	recruitment	recruitment	NN	NN	_	13	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	EKLF	eklf	NN	NN	_	19	nmod	_	_
22	to	to	TO	TO	_	23	case	_	_
23	5'HS2	5'hs2	NN	NN	_	19	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	5'HS3	5'hs3	NN	NN	_	23	conj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	LCR	lcr	NN	NN	_	23	nmod	_	_
29	.	.	.	.	_	6	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	find	find	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	9	mark	_	_
4	recruitment	recruitment	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	EKLF	eklf	NN	NN	_	4	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	5'HS2	5'hs2	NN	NN	_	4	nmod	_	_
9	requires	require	VBZ	VBZ	_	2	ccomp	_	_
10	the	the	DT	DT	_	12	det	_	_
11	TATA	tata	NN	NN	_	12	compound	_	_
12	box	box	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	9	punct	_	_
14	but	but	CC	CC	_	9	cc	_	_
15	recruitment	recruitment	NN	NN	_	18	nsubj	_	_
16	to	to	TO	TO	_	17	case	_	_
17	5'HS3	5'hs3	NN	NN	_	15	nmod	_	_
18	depends	depend	VBZ	VBZ	_	9	conj	_	_
19	on	on	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	CACCC	caccc	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	TATA	tata	NN	NN	_	21	conj	_	_
24	boxes	box	NNS	NNS	_	21	dep	_	_
25	of	of	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	beta-globin	beta-globin	NN	NN	_	28	compound	_	_
28	promoter	promoter	NN	NN	_	21	nmod	_	_
29	.	.	.	.	_	2	punct	_	_

1	Furthermore	furthermore	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	recruitment	recruitment	NN	NN	_	9	nsubj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	EKLF	eklf	NN	NN	_	3	nmod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	5'HS3	5'hs3	NN	NN	_	3	nmod	_	_
8	only	only	RB	RB	_	9	advmod	_	_
9	occurred	occur	VBD	VBD	_	0	root	_	_
10	in	in	IN	IN	_	15	case	_	_
11	beta-globin-expressing	beta-globin-expressing	JJ	JJ	_	15	amod	_	_
12	murine	murine	JJ	JJ	_	15	amod	_	_
13	erythroid	erythroid	JJ	JJ	_	15	amod	_	_
14	leukemia	leukemia	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	,	,	,	,	_	9	punct	_	_
17	whereas	whereas	IN	IN	_	9	dep	_	_
18	recruitment	recruitment	NN	NN	_	23	nsubj	_	_
19	of	of	IN	IN	_	20	case	_	_
20	EKLF	eklf	NN	NN	_	18	nmod	_	_
21	to	to	TO	TO	_	22	case	_	_
22	5'HS2	5'hs2	NN	NN	_	18	nmod	_	_
23	occurred	occur	VBD	VBD	_	9	parataxis	_	_
24	in	in	IN	IN	_	28	case	_	_
25	both	both	CC	CC	_	28	cc:preconj	_	_
26	gamma-globin-expressing	gamma-globin-expressing	JJ	JJ	_	28	amod	_	_
27	K562	k562	NN	NN	_	28	compound	_	_
28	cells	cell	NNS	NNS	_	23	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	murine	murine	JJ	JJ	_	33	amod	_	_
31	erythroid	erythroid	JJ	JJ	_	33	amod	_	_
32	leukemia	leukemia	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	28	conj	_	_
34	.	.	.	.	_	9	punct	_	_

1	Unlike	unlike	IN	IN	_	2	case	_	_
2	EKLF	eklf	NN	NN	_	15	nmod	_	_
3	,	,	,	,	_	15	punct	_	_
4	Sp1	sp1	NN	NN	_	15	nsubjpass	_	_
5	,	,	,	,	_	4	punct	_	_
6	which	which	WDT	WDT	_	8	nsubj	_	_
7	also	also	RB	RB	_	8	advmod	_	_
8	binds	bind	VBZ	VBZ	_	4	acl:relcl	_	_
9	to	to	TO	TO	_	11	case	_	_
10	CACCC	caccc	NN	NN	_	11	compound	_	_
11	boxes	box	NNS	NNS	_	8	nmod	_	_
12	,	,	,	,	_	4	punct	_	_
13	is	be	VBZ	VBZ	_	15	auxpass	_	_
14	not	not	RB	RB	_	15	neg	_	_
15	recruited	recruit	VBN	VBN	_	0	root	_	_
16	to	to	TO	TO	_	17	case	_	_
17	5'HS3	5'hs3	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	15	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	examined	examine	VBN	VBN	_	0	root	_	_
5	how	how	WRB	WRB	_	8	advmod	_	_
6	one	one	CD	CD	_	7	nummod	_	_
7	5'HS	5'hs	NN	NN	_	8	nsubj	_	_
8	affects	affect	VBZ	VBZ	_	4	ccomp	_	_
9	the	the	DT	DT	_	10	det	_	_
10	recruitment	recruitment	NN	NN	_	8	dobj	_	_
11	of	of	IN	IN	_	12	case	_	_
12	EKLF	eklf	NN	NN	_	10	nmod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	another	another	DT	DT	_	15	det	_	_
15	5'HS	5'hs	NN	NN	_	10	nmod	_	_
16	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	found	find	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	the	the	DT	DT	_	6	det	_	_
6	recruitment	recruitment	NN	NN	_	11	nsubj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	EKLF	eklf	NN	NN	_	6	nmod	_	_
9	to	to	TO	TO	_	10	case	_	_
10	5'HS3	5'hs3	NN	NN	_	6	nmod	_	_
11	depends	depend	VBZ	VBZ	_	3	ccomp	_	_
12	on	on	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	presence	presence	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	5'HS2	5'hs2	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	cis	cis	NN	NN	_	14	nmod	_	_
19	,	,	,	,	_	11	punct	_	_
20	but	but	CC	CC	_	11	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	recruitment	recruitment	NN	NN	_	27	nsubj	_	_
23	to	to	TO	TO	_	24	case	_	_
24	5'HS2	5'hs2	NN	NN	_	22	nmod	_	_
25	does	do	VBZ	VBZ	_	27	aux	_	_
26	not	not	RB	RB	_	27	neg	_	_
27	depend	depend	VB	VB	_	11	conj	_	_
28	on	on	IN	IN	_	29	case	_	_
29	5'HS3	5'hs3	NN	NN	_	27	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Based	base	VBN	VBN	_	4	case	_	_
2	on	on	IN	IN	_	4	case	_	_
3	these	these	DT	DT	_	4	det	_	_
4	results	result	NNS	NNS	_	7	advcl	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	present	present	VBP	VBP	_	0	root	_	_
8	a	a	DT	DT	_	9	det	_	_
9	model	model	NN	NN	_	7	dobj	_	_
10	that	that	WDT	WDT	_	11	nsubj	_	_
11	illustrates	illustrate	VBZ	VBZ	_	9	acl:relcl	_	_
12	how	how	WRB	WRB	_	16	advmod	_	_
13	EKLF	eklf	NN	NN	_	16	nsubjpass	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	auxpass	_	_
16	recruited	recruit	VBN	VBN	_	11	ccomp	_	_
17	to	to	TO	TO	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	beta-globin	beta-globin	NN	NN	_	20	compound	_	_
20	locus	locus	NN	NN	_	16	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	E1A	e1a	NN	NN	_	3	compound	_	_
2	oncogene	oncogene	NN	NN	_	3	compound	_	_
3	induction	induction	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	susceptibility	susceptibility	NN	NN	_	3	nmod	_	_
7	to	to	TO	TO	_	8	case	_	_
8	killing	killing	NN	NN	_	6	nmod	_	_
9	by	by	IN	IN	_	11	case	_	_
10	cytolytic	cytolytic	JJ	JJ	_	11	amod	_	_
11	lymphocytes	lymphocyte	NNS	NNS	_	8	nmod	_	_
12	through	through	IN	IN	_	15	case	_	_
13	target	target	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	sensitization	sensitization	NN	NN	_	8	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	apoptotic	apoptotic	JJ	JJ	_	18	amod	_	_
18	injury	injury	NN	NN	_	15	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	E1A	e1a	NN	NN	_	3	compound	_	_
2	oncogene	oncogene	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	4	nsubj	_	_
4	increases	increase	VBZ	VBZ	_	0	root	_	_
5	mammalian	mammalian	JJ	JJ	_	7	amod	_	_
6	cell	cell	NN	NN	_	7	compound	_	_
7	susceptibility	susceptibility	NN	NN	_	4	dobj	_	_
8	to	to	TO	TO	_	9	case	_	_
9	lysis	lysis	NN	NN	_	7	nmod	_	_
10	by	by	IN	IN	_	12	case	_	_
11	cytolytic	cytolytic	JJ	JJ	_	12	amod	_	_
12	lymphocytes	lymphocyte	NNS	NNS	_	4	nmod	_	_
13	(	(	-LRB-	-LRB-	_	14	punct	_	_
14	CLs	cl	NNS	NNS	_	12	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	at	at	IN	IN	_	18	case	_	_
17	a	a	DT	DT	_	18	det	_	_
18	stage	stage	NN	NN	_	4	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	this	this	DT	DT	_	22	det	_	_
21	intercellular	intercellular	JJ	JJ	_	22	amod	_	_
22	interaction	interaction	NN	NN	_	18	nmod	_	_
23	that	that	WDT	WDT	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	independent	independent	JJ	JJ	_	22	acl:relcl	_	_
26	of	of	IN	IN	_	30	case	_	_
27	cell	cell	NN	NN	_	30	compound	_	_
28	surface	surface	NN	NN	_	30	compound	_	_
29	recognition	recognition	NN	NN	_	30	compound	_	_
30	events	event	NNS	NNS	_	25	nmod	_	_
31	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	CLs	cls	NN	NN	_	4	nsubj	_	_
3	can	can	MD	MD	_	4	aux	_	_
4	induce	induce	VB	VB	_	13	advcl	_	_
5	either	either	CC	CC	_	10	dep	_	_
6	apoptotic	apoptotic	JJ	JJ	_	10	dep	_	_
7	or	or	CC	CC	_	6	cc	_	_
8	necrotic	necrotic	JJ	JJ	_	6	conj	_	_
9	cell	cell	NN	NN	_	10	compound	_	_
10	death	death	NN	NN	_	4	dobj	_	_
11	,	,	,	,	_	13	punct	_	_
12	we	we	PRP	PRP	_	13	nsubj	_	_
13	asked	ask	VBD	VBD	_	0	root	_	_
14	whether	whether	IN	IN	_	21	mark	_	_
15	E1A	e1a	NN	NN	_	16	compound	_	_
16	sensitization	sensitization	NN	NN	_	21	nsubj	_	_
17	to	to	TO	TO	_	19	case	_	_
18	injury-induced	injury-induced	JJ	JJ	_	19	amod	_	_
19	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	sufficient	sufficient	JJ	JJ	_	13	ccomp	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	explain	explain	VB	VB	_	21	xcomp	_	_
24	E1A-induced	e1a-induced	JJ	JJ	_	26	amod	_	_
25	cytolytic	cytolytic	JJ	JJ	_	26	amod	_	_
26	susceptibility	susceptibility	NN	NN	_	23	dobj	_	_
27	.	.	.	.	_	13	punct	_	_

1	Mouse	mouse	NN	NN	_	19	nsubjpass	_	_
2	,	,	,	,	_	1	punct	_	_
3	rat	rat	NN	NN	_	1	conj	_	_
4	,	,	,	,	_	1	punct	_	_
5	hamster	hamster	NN	NN	_	1	conj	_	_
6	,	,	,	,	_	1	punct	_	_
7	and	and	CC	CC	_	1	cc	_	_
8	human	human	JJ	JJ	_	1	conj	_	_
9	cells	cell	NNS	NNS	_	1	dep	_	_
10	that	that	WDT	WDT	_	12	nsubjpass	_	_
11	were	be	VBD	VBD	_	12	auxpass	_	_
12	rendered	render	VBN	VBN	_	1	acl:relcl	_	_
13	cytolytic	cytolytic	JJ	JJ	_	14	amod	_	_
14	susceptible	susceptible	JJ	JJ	_	12	xcomp	_	_
15	by	by	IN	IN	_	16	case	_	_
16	E1A	e1a	NN	NN	_	12	nmod	_	_
17	were	be	VBD	VBD	_	19	auxpass	_	_
18	also	also	RB	RB	_	19	advmod	_	_
19	sensitized	sensitize	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	25	case	_	_
21	CL-induced	cl-induced	JJ	JJ	_	25	amod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	chemically	chemically	RB	RB	_	24	advmod	_	_
24	induced	induce	VBN	VBN	_	21	conj	_	_
25	apoptosis	apoptosis	NN	NN	_	19	nmod	_	_
26	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	9	nmod	_	_
3	,	,	,	,	_	9	punct	_	_
4	E1A-positive	e1a-positive	JJ	JJ	_	5	amod	_	_
5	cells	cell	NNS	NNS	_	9	nsubj	_	_
6	were	be	VBD	VBD	_	9	cop	_	_
7	no	no	DT	DT	_	9	neg	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	susceptible	susceptible	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	12	case	_	_
11	injury-induced	injury-induced	JJ	JJ	_	12	amod	_	_
12	necrosis	necrosis	NN	NN	_	9	nmod	_	_
13	than	than	IN	IN	_	15	case	_	_
14	E1A-negative	e1a-negative	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	9	nmod	_	_
16	.	.	.	.	_	9	punct	_	_

1	Similar	similar	JJ	JJ	_	21	dep	_	_
2	to	to	TO	TO	_	3	case	_	_
3	induction	induction	NN	NN	_	1	nmod	_	_
4	of	of	IN	IN	_	6	case	_	_
5	cytolytic	cytolytic	JJ	JJ	_	6	amod	_	_
6	susceptibility	susceptibility	NN	NN	_	3	nmod	_	_
7	and	and	CC	CC	_	1	cc	_	_
8	in	in	IN	IN	_	9	case	_	_
9	contrast	contrast	NN	NN	_	1	conj	_	_
10	to	to	TO	TO	_	13	case	_	_
11	other	other	JJ	JJ	_	13	amod	_	_
12	E1A	e1a	NN	NN	_	13	compound	_	_
13	activities	activity	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	21	punct	_	_
15	cellular	cellular	JJ	JJ	_	16	amod	_	_
16	sensitization	sensitization	NN	NN	_	21	nsubj	_	_
17	to	to	TO	TO	_	20	case	_	_
18	chemically	chemically	RB	RB	_	19	advmod	_	_
19	induced	induce	VBN	VBN	_	20	amod	_	_
20	apoptosis	apoptosis	NN	NN	_	16	nmod	_	_
21	depended	depend	VBD	VBD	_	0	root	_	_
22	on	on	IN	IN	_	26	case	_	_
23	high-level	high-level	JJ	JJ	_	26	amod	_	_
24	E1A	e1a	NN	NN	_	26	compound	_	_
25	oncoprotein	oncoprotein	NN	NN	_	26	compound	_	_
26	expression	expression	NN	NN	_	21	nmod	_	_
27	.	.	.	.	_	21	punct	_	_

1	Loss	loss	NN	NN	_	13	nsubjpass	_	_
2	of	of	IN	IN	_	5	case	_	_
3	both	both	CC	CC	_	5	cc:preconj	_	_
4	cytolytic	cytolytic	JJ	JJ	_	5	amod	_	_
5	susceptibility	susceptibility	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	sensitization	sensitization	NN	NN	_	5	conj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	chemically	chemically	RB	RB	_	10	advmod	_	_
10	induced	induce	VBN	VBN	_	11	amod	_	_
11	apoptosis	apoptosis	NN	NN	_	7	nmod	_	_
12	was	be	VBD	VBD	_	13	auxpass	_	_
13	coselected	coselect	VBN	VBN	_	0	root	_	_
14	during	during	IN	IN	_	17	case	_	_
15	in	in	FW	FW	_	17	amod	_	_
16	vivo	vivo	FW	FW	_	15	dep	_	_
17	selection	selection	NN	NN	_	13	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	E1A-positive	e1a-positive	JJ	JJ	_	21	amod	_	_
20	sarcoma	sarcoma	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	17	nmod	_	_
22	for	for	IN	IN	_	24	case	_	_
23	increased	increase	VBN	VBN	_	24	amod	_	_
24	tumorigenicity	tumorigenicity	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	13	punct	_	_

1	Furthermore	furthermore	RB	RB	_	25	advmod	_	_
2	,	,	,	,	_	25	punct	_	_
3	E1A	e1a	NN	NN	_	5	compound	_	_
4	mutant	mutant	JJ	JJ	_	5	amod	_	_
5	proteins	protein	NNS	NNS	_	25	nsubj	_	_
6	that	that	WDT	WDT	_	9	nsubj	_	_
7	can	can	MD	MD	_	9	aux	_	_
8	not	not	RB	RB	_	9	neg	_	_
9	bind	bind	VB	VB	_	5	acl:relcl	_	_
10	the	the	DT	DT	_	15	det	_	_
11	cellular	cellular	JJ	JJ	_	15	amod	_	_
12	transcriptional	transcriptional	JJ	JJ	_	15	amod	_	_
13	coactivator	coactivator	NN	NN	_	15	compound	_	_
14	,	,	,	,	_	15	punct	_	_
15	p300	p300	NN	NN	_	9	dobj	_	_
16	,	,	,	,	_	15	punct	_	_
17	and	and	CC	CC	_	9	cc	_	_
18	that	that	WDT	WDT	_	19	nsubj	_	_
19	fail	fail	VBP	VBP	_	9	conj	_	_
20	to	to	TO	TO	_	21	mark	_	_
21	induce	induce	VB	VB	_	19	xcomp	_	_
22	cytolytic	cytolytic	JJ	JJ	_	23	amod	_	_
23	susceptibility	susceptibility	NN	NN	_	21	dobj	_	_
24	also	also	RB	RB	_	25	advmod	_	_
25	failed	fail	VBD	VBD	_	0	root	_	_
26	to	to	TO	TO	_	27	mark	_	_
27	sensitize	sensitize	VB	VB	_	25	xcomp	_	_
28	cells	cell	NNS	NNS	_	27	dobj	_	_
29	to	to	TO	TO	_	31	case	_	_
30	injury-induced	injury-induced	JJ	JJ	_	31	amod	_	_
31	apoptosis	apoptosis	NN	NN	_	27	nmod	_	_
32	.	.	.	.	_	25	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	E1A	e1a	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	susceptibility	susceptibility	NN	NN	_	6	dobj	_	_
8	to	to	TO	TO	_	11	case	_	_
9	killer	killer	NN	NN	_	11	compound	_	_
10	cell-induced	cell-induced	JJ	JJ	_	11	amod	_	_
11	lysis	lysis	NN	NN	_	7	nmod	_	_
12	through	through	IN	IN	_	13	case	_	_
13	sensitization	sensitization	NN	NN	_	6	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	cells	cell	NNS	NNS	_	13	nmod	_	_
16	to	to	TO	TO	_	18	case	_	_
17	injury-induced	injury-induced	JJ	JJ	_	18	amod	_	_
18	apoptosis	apoptosis	NN	NN	_	13	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Copyright	copyright	NN	NN	_	4	compound	_	_
2	1999	1999	CD	CD	_	4	nummod	_	_
3	Academic	Academic	NNP	NNP	_	4	compound	_	_
4	Press	Press	NNP	NNP	_	0	root	_	_
5	.	.	.	.	_	4	punct	_	_

1	Polyamines	polyamine	NNS	NNS	_	0	root	_	_
2	in	in	IN	IN	_	5	case	_	_
3	human	human	JJ	JJ	_	5	amod	_	_
4	breast	breast	NN	NN	_	5	compound	_	_
5	cancer	cancer	NN	NN	_	1	nmod	_	_
6	and	and	CC	CC	_	1	cc	_	_
7	its	its	PRP$	PRP$	_	8	nmod:poss	_	_
8	relations	relation	NNS	NNS	_	1	conj	_	_
9	to	to	TO	TO	_	12	case	_	_
10	classical	classical	JJ	JJ	_	12	amod	_	_
11	prognostic	prognostic	JJ	JJ	_	12	amod	_	_
12	features	feature	NNS	NNS	_	8	nmod	_	_
13	:	:	:	:	_	1	punct	_	_
14	clinical	clinical	JJ	JJ	_	15	amod	_	_
15	implications	implication	NNS	NNS	_	1	dep	_	_
16	.	.	.	.	_	1	punct	_	_

1	Experimental	experimental	JJ	JJ	_	2	amod	_	_
2	evidence	evidence	NN	NN	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	important	important	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	8	case	_	_
8	polyamines	polyamine	NNS	NNS	_	6	nmod	_	_
9	in	in	IN	IN	_	12	case	_	_
10	breast	breast	NN	NN	_	12	compound	_	_
11	cancer	cancer	NN	NN	_	12	compound	_	_
12	development	development	NN	NN	_	6	nmod	_	_
13	.	.	.	.	_	3	punct	_	_

1	Polyamines	polyamine	NNS	NNS	_	4	nsubjpass	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	been	be	VBN	VBN	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	6	case	_	_
6	tissue	tissue	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	erythrocyte	erythrocyte	NN	NN	_	6	conj	_	_
9	samples	sample	NNS	NNS	_	6	dep	_	_
10	from	from	IN	IN	_	12	case	_	_
11	100	100	CD	CD	_	12	nummod	_	_
12	patients	patient	NNS	NNS	_	6	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	primary	primary	JJ	JJ	_	17	amod	_	_
15	invasive	invasive	JJ	JJ	_	17	amod	_	_
16	breast	breast	NN	NN	_	17	compound	_	_
17	cancer	cancer	NN	NN	_	12	nmod	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	30	30	CD	CD	_	20	nummod	_	_
20	patients	patient	NNS	NNS	_	12	conj	_	_
21	with	with	IN	IN	_	22	case	_	_
22	fibroadenomas	fibroadenoma	NNS	NNS	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Statistical	statistical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	performed	perform	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	mark	_	_
6	order	order	NN	NN	_	5	mwe	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	determine	determine	VB	VB	_	4	advcl	_	_
9	the	the	DT	DT	_	11	det	_	_
10	prognostic	prognostic	JJ	JJ	_	11	amod	_	_
11	value	value	NN	NN	_	8	dobj	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	polyamine	polyamine	NN	NN	_	15	compound	_	_
15	patterns	pattern	NNS	NNS	_	11	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	tumor	tumor	NN	NN	_	18	compound	_	_
18	tissues	tissue	NNS	NNS	_	15	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	erythrocytes	erythrocyte	NNS	NNS	_	18	conj	_	_
21	in	in	IN	IN	_	22	case	_	_
22	comparison	comparison	NN	NN	_	8	nmod	_	_
23	with	with	IN	IN	_	28	case	_	_
24	clinical	clinical	JJ	JJ	_	28	amod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	histological	histological	JJ	JJ	_	24	conj	_	_
27	prognostic	prognostic	JJ	JJ	_	28	amod	_	_
28	factors	factor	NNS	NNS	_	22	nmod	_	_
29	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	malignant	malignant	JJ	JJ	_	3	amod	_	_
3	tissues	tissue	NNS	NNS	_	9	nmod	_	_
4	,	,	,	,	_	9	punct	_	_
5	polyamine	polyamine	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	9	nsubj	_	_
7	were	be	VBD	VBD	_	9	cop	_	_
8	significantly	significantly	RB	RB	_	9	advmod	_	_
9	higher	higher	JJR	JJR	_	0	root	_	_
10	than	than	IN	IN	_	13	case	_	_
11	in	in	IN	IN	_	13	case	_	_
12	benign	benign	JJ	JJ	_	13	amod	_	_
13	tissues	tissue	NNS	NNS	_	9	nmod	_	_
14	.	.	.	.	_	9	punct	_	_

1	They	they	PRP	PRP	_	2	nsubj	_	_
2	correlated	correlate	VBD	VBD	_	0	root	_	_
3	with	with	IN	IN	_	4	case	_	_
4	markers	marker	NNS	NNS	_	2	nmod	_	_
5	of	of	IN	IN	_	7	case	_	_
6	tumor	tumor	NN	NN	_	7	compound	_	_
7	aggressivity	aggressivity	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	11	punct	_	_
9	axillary	axillary	JJ	JJ	_	11	amod	_	_
10	node	node	NN	NN	_	11	compound	_	_
11	involvement	involvement	NN	NN	_	4	dep	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	especially	especially	RB	RB	_	11	nmod	_	_
14	with	with	IN	IN	_	15	case	_	_
15	markers	marker	NNS	NNS	_	13	nmod	_	_
16	of	of	IN	IN	_	19	case	_	_
17	high	high	JJ	JJ	_	19	amod	_	_
18	mitotic	mitotic	JJ	JJ	_	19	amod	_	_
19	rate	rate	NN	NN	_	15	nmod	_	_
20	as	as	IN	IN	_	22	case	_	_
21	Ki-67	ki-67	NN	NN	_	22	compound	_	_
22	staining	staining	NN	NN	_	15	nmod	_	_
23	,	,	,	,	_	22	punct	_	_
24	histological	histological	JJ	JJ	_	25	amod	_	_
25	grade	grade	NN	NN	_	22	appos	_	_
26	)	)	-RRB-	-RRB-	_	11	punct	_	_
27	.	.	.	.	_	2	punct	_	_

1	No	no	DT	DT	_	2	neg	_	_
2	correlation	correlation	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	found	find	VBN	VBN	_	0	root	_	_
5	between	between	IN	IN	_	6	case	_	_
6	estrogen	estrogen	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	progesterone	progesterone	NN	NN	_	6	conj	_	_
9	status	status	NN	NN	_	6	dep	_	_
10	,	,	,	,	_	6	punct	_	_
11	tumor	tumor	NN	NN	_	12	compound	_	_
12	size	size	NN	NN	_	6	dep	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	polyamine	polyamine	NN	NN	_	15	compound	_	_
15	concentrations	concentration	NNS	NNS	_	12	conj	_	_
16	.	.	.	.	_	4	punct	_	_

1	Erythrocyte	erythrocyte	NN	NN	_	3	compound	_	_
2	polyamines	polyamine	NNS	NNS	_	3	compound	_	_
3	levels	level	NNS	NNS	_	5	nsubj	_	_
4	were	be	VBD	VBD	_	5	cop	_	_
5	identical	identical	JJ	JJ	_	0	root	_	_
6	between	between	IN	IN	_	8	case	_	_
7	cancer	cancer	NN	NN	_	8	compound	_	_
8	patients	patient	NNS	NNS	_	5	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	controls	control	NNS	NNS	_	8	conj	_	_
11	.	.	.	.	_	5	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	knowledge	knowledge	NN	NN	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	polyamine	polyamine	NN	NN	_	6	compound	_	_
6	pattern	pattern	NN	NN	_	2	nmod	_	_
7	in	in	IN	IN	_	9	case	_	_
8	breast	breast	NN	NN	_	9	compound	_	_
9	cancer	cancer	NN	NN	_	6	nmod	_	_
10	could	could	MD	MD	_	11	aux	_	_
11	become	become	VB	VB	_	0	root	_	_
12	useful	useful	JJ	JJ	_	11	xcomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	clinical	clinical	JJ	JJ	_	15	case	_	_
15	practice	practice	NN	NN	_	11	advcl	_	_
16	particularly	particularly	RB	RB	_	21	advmod	_	_
17	if	if	IN	IN	_	21	mark	_	_
18	polyamine	polyamine	NN	NN	_	19	compound	_	_
19	metabolism	metabolism	NN	NN	_	21	nsubjpass	_	_
20	is	be	VBZ	VBZ	_	21	auxpass	_	_
21	targeted	target	VBN	VBN	_	11	advcl	_	_
22	as	as	IN	IN	_	25	case	_	_
23	a	a	DT	DT	_	25	det	_	_
24	therapeutic	therapeutic	JJ	JJ	_	25	amod	_	_
25	approach	approach	NN	NN	_	21	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	activation-responsive	activation-responsive	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	11	nsubj	_	_
4	in	in	IN	IN	_	8	case	_	_
5	single	single	JJ	JJ	_	8	amod	_	_
6	C	c	NN	NN	_	8	compound	_	_
7	motif-1/lymphotactin	motif-1/lymphotactin	JJ	JJ	_	8	amod	_	_
8	promoter	promoter	NN	NN	_	3	nmod	_	_
9	is	be	VBZ	VBZ	_	11	cop	_	_
10	a	a	DT	DT	_	11	det	_	_
11	site	site	NN	NN	_	0	root	_	_
12	of	of	IN	IN	_	17	case	_	_
13	constitutive	constitutive	JJ	JJ	_	17	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	inducible	inducible	JJ	JJ	_	13	conj	_	_
16	DNA-protein	dna-protein	JJ	JJ	_	17	amod	_	_
17	interactions	interaction	NNS	NNS	_	11	nmod	_	_
18	involving	involve	VBG	VBG	_	24	case	_	_
19	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
20	factor	factor	NN	NN	_	24	compound	_	_
21	of	of	IN	IN	_	24	amod	_	_
22	activated	activate	VBN	VBN	_	24	amod	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cell	cell	NN	NN	_	17	nmod	_	_
25	.	.	.	.	_	11	punct	_	_

1	Single	single	JJ	JJ	_	7	amod	_	_
2	C	c	NN	NN	_	7	compound	_	_
3	motif-1	motif-1	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	SCM-1	scm-1	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	/lymphotactin	/lymphotactin	NN	NN	_	11	nsubj	_	_
8	is	be	VBZ	VBZ	_	11	cop	_	_
9	a	a	DT	DT	_	11	det	_	_
10	C-type	c-type	JJ	JJ	_	11	amod	_	_
11	chemokine	chemokine	NN	NN	_	0	root	_	_
12	whose	whose	WP$	WP$	_	13	nmod:poss	_	_
13	expression	expression	NN	NN	_	16	nsubj	_	_
14	is	be	VBZ	VBZ	_	16	cop	_	_
15	activation	activation	NN	NN	_	16	nmod:npmod	_	_
16	dependent	dependent	JJ	JJ	_	11	acl:relcl	_	_
17	,	,	,	,	_	16	punct	_	_
18	cyclosporin	cyclosporin	NN	NN	_	20	nmod:npmod	_	_
19	A	a	NN	NN	_	20	nmod:npmod	_	_
20	sensitive	sensitive	JJ	JJ	_	16	conj	_	_
21	and	and	CC	CC	_	16	cc	_	_
22	restricted	restricted	JJ	JJ	_	16	conj	_	_
23	to	to	TO	TO	_	26	case	_	_
24	CD8+	cd8+	JJ	JJ	_	26	amod	_	_
25	T	t	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	22	nmod	_	_
27	,	,	,	,	_	26	punct	_	_
28	double-negative	double-negative	JJ	JJ	_	29	amod	_	_
29	thymocytes	thymocyte	NNS	NNS	_	26	conj	_	_
30	,	,	,	,	_	26	punct	_	_
31	gammadelta-type	gammadelta-type	JJ	JJ	_	33	amod	_	_
32	T	t	NN	NN	_	33	compound	_	_
33	cells	cell	NNS	NNS	_	26	conj	_	_
34	,	,	,	,	_	26	punct	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	NK	nk	NN	NN	_	37	compound	_	_
37	cells	cell	NNS	NNS	_	26	conj	_	_
38	.	.	.	.	_	11	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	humans	human	NNS	NNS	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	there	there	EX	EX	_	5	expl	_	_
5	are	be	VBP	VBP	_	0	root	_	_
6	two	two	CD	CD	_	9	nummod	_	_
7	highly	highly	RB	RB	_	9	advmod	_	_
8	homologous	homologous	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	5	nsubj	_	_
10	encoding	encode	VBG	VBG	_	9	acl	_	_
11	SCM-1alpha	scm-1alpha	NN	NN	_	10	dobj	_	_
12	and	and	CC	CC	_	11	cc	_	_
13	SCM-1beta	scm-1beta	NN	NN	_	11	conj	_	_
14	.	.	.	.	_	5	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	examined	examine	VBD	VBD	_	0	root	_	_
4	the	the	DT	DT	_	6	det	_	_
5	regulatory	regulatory	JJ	JJ	_	6	amod	_	_
6	mechanism	mechanism	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	the	the	DT	DT	_	10	det	_	_
9	SCM-1	scm-1	NN	NN	_	10	compound	_	_
10	genes	gene	NNS	NNS	_	6	nmod	_	_
11	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	luciferase	luciferase	NN	NN	_	4	compound	_	_
3	reporter	reporter	NN	NN	_	4	compound	_	_
4	gene	gene	NN	NN	_	18	nsubjpass	_	_
5	under	under	IN	IN	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	control	control	NN	NN	_	4	nmod	_	_
8	of	of	IN	IN	_	12	case	_	_
9	the	the	DT	DT	_	12	det	_	_
10	5'	5'	JJ	JJ	_	12	amod	_	_
11	flanking	flanking	JJ	JJ	_	12	amod	_	_
12	region	region	NN	NN	_	7	nmod	_	_
13	of	of	IN	IN	_	15	case	_	_
14	0.7	0.7	CD	CD	_	15	nummod	_	_
15	kb	kb	NN	NN	_	12	nmod	_	_
16	was	be	VBD	VBD	_	18	auxpass	_	_
17	strongly	strongly	RB	RB	_	18	advmod	_	_
18	induced	induce	VBN	VBN	_	0	root	_	_
19	upon	upon	IN	IN	_	20	case	_	_
20	activation	activation	NN	NN	_	18	nmod	_	_
21	with	with	IN	IN	_	22	case	_	_
22	anti-CD3	anti-cd3	NN	NN	_	20	nmod	_	_
23	or	or	CC	CC	_	22	cc	_	_
24	PHA	pha	NN	NN	_	22	conj	_	_
25	plus	plus	CC	CC	_	24	cc	_	_
26	PMA	pma	NN	NN	_	24	conj	_	_
27	only	only	RB	RB	_	32	advmod	_	_
28	in	in	IN	IN	_	32	case	_	_
29	SCM-1-producer	scm-1-producer	JJ	JJ	_	32	amod	_	_
30	T	t	NN	NN	_	32	compound	_	_
31	cell	cell	NN	NN	_	32	compound	_	_
32	lines	line	NNS	NNS	_	18	nmod	_	_
33	through	through	IN	IN	_	37	case	_	_
34	a	a	DT	DT	_	37	det	_	_
35	cyclosporin	cyclosporin	NN	NN	_	37	compound	_	_
36	A-sensitive	a-sensitive	JJ	JJ	_	37	amod	_	_
37	mechanism	mechanism	NN	NN	_	18	nmod	_	_
38	.	.	.	.	_	18	punct	_	_

1	An	a	DT	DT	_	2	det	_	_
2	element	element	NN	NN	_	19	nsubjpass	_	_
3	termed	term	VBN	VBN	_	2	acl	_	_
4	E1	e1	NN	NN	_	3	xcomp	_	_
5	located	located	JJ	JJ	_	2	amod	_	_
6	at	at	IN	IN	_	10	case	_	_
7	-108	-108	CD	CD	_	10	nummod	_	_
8	to	to	TO	TO	_	10	dep	_	_
9	-95	-95	CD	CD	_	10	nummod	_	_
10	nt	nt	NN	NN	_	5	nmod	_	_
11	relative	relative	JJ	JJ	_	17	case	_	_
12	to	to	TO	TO	_	17	case	_	_
13	the	the	DT	DT	_	17	det	_	_
14	major	major	JJ	JJ	_	17	amod	_	_
15	transcription	transcription	NN	NN	_	17	compound	_	_
16	start	start	NN	NN	_	17	compound	_	_
17	site	site	NN	NN	_	5	nmod	_	_
18	was	be	VBD	VBD	_	19	auxpass	_	_
19	found	find	VBN	VBN	_	0	root	_	_
20	to	to	TO	TO	_	22	mark	_	_
21	be	be	VB	VB	_	22	cop	_	_
22	critical	critical	JJ	JJ	_	19	xcomp	_	_
23	for	for	IN	IN	_	26	case	_	_
24	the	the	DT	DT	_	26	det	_	_
25	promoter	promoter	NN	NN	_	26	compound	_	_
26	activity	activity	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	19	punct	_	_

1	In	in	IN	IN	_	5	case	_	_
2	electrophoretic	electrophoretic	JJ	JJ	_	5	amod	_	_
3	mobility	mobility	NN	NN	_	5	compound	_	_
4	shift	shift	NN	NN	_	5	compound	_	_
5	assays	assay	NNS	NNS	_	22	nmod	_	_
6	using	use	VBG	VBG	_	5	acl	_	_
7	the	the	DT	DT	_	9	det	_	_
8	E1	e1	NN	NN	_	9	compound	_	_
9	oligonucleotide	oligonucleotide	NN	NN	_	6	dobj	_	_
10	as	as	IN	IN	_	11	case	_	_
11	probe	probe	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	22	punct	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	extracts	extract	NNS	NNS	_	22	nsubj	_	_
15	from	from	IN	IN	_	17	case	_	_
16	unstimulated	unstimulated	JJ	JJ	_	17	amod	_	_
17	T	t	NN	NN	_	14	nmod	_	_
18	and	and	CC	CC	_	17	cc	_	_
19	B	b	NN	NN	_	17	conj	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	lines	line	NNS	NNS	_	17	dep	_	_
22	formed	form	VBD	VBD	_	0	root	_	_
23	a	a	DT	DT	_	25	det	_	_
24	constitutive	constitutive	JJ	JJ	_	25	amod	_	_
25	complex	complex	NN	NN	_	22	dobj	_	_
26	termed	term	VBN	VBN	_	25	acl	_	_
27	complex	complex	NN	NN	_	28	compound	_	_
28	I	i	NN	NN	_	26	xcomp	_	_
29	,	,	,	,	_	22	punct	_	_
30	while	while	IN	IN	_	39	mark	_	_
31	nuclear	nuclear	JJ	JJ	_	32	amod	_	_
32	extracts	extract	NNS	NNS	_	39	nsubj	_	_
33	from	from	IN	IN	_	38	case	_	_
34	stimulated	stimulate	VBN	VBN	_	38	amod	_	_
35	SCM-1-producer	scm-1-producer	NN	NN	_	38	compound	_	_
36	T	t	NN	NN	_	38	compound	_	_
37	cell	cell	NN	NN	_	38	compound	_	_
38	lines	line	NNS	NNS	_	32	nmod	_	_
39	formed	form	VBD	VBD	_	22	advcl	_	_
40	a	a	DT	DT	_	43	det	_	_
41	higher	higher	JJR	JJR	_	43	amod	_	_
42	mobility	mobility	NN	NN	_	43	compound	_	_
43	complex	complex	NN	NN	_	39	dobj	_	_
44	termed	term	VBN	VBN	_	43	acl	_	_
45	complex	complex	NN	NN	_	44	xcomp	_	_
46	II	ii	CD	CD	_	45	nummod	_	_
47	with	with	IN	IN	_	50	case	_	_
48	a	a	DT	DT	_	50	det	_	_
49	concomitant	concomitant	JJ	JJ	_	50	amod	_	_
50	decrease	decrease	NN	NN	_	39	nmod	_	_
51	in	in	IN	IN	_	52	case	_	_
52	complex	complex	NN	NN	_	50	nmod	_	_
53	I	i	CD	CD	_	52	nummod	_	_
54	.	.	.	.	_	22	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	shift	shift	NN	NN	_	20	nsubjpass	_	_
3	from	from	IN	IN	_	4	case	_	_
4	complex	complex	NN	NN	_	2	nmod	_	_
5	I	i	CD	CD	_	4	nummod	_	_
6	to	to	TO	TO	_	7	case	_	_
7	complex	complex	NN	NN	_	4	nmod	_	_
8	II	ii	CD	CD	_	7	nummod	_	_
9	seen	see	VBN	VBN	_	2	acl	_	_
10	only	only	RB	RB	_	9	advcl	_	_
11	in	in	IN	IN	_	15	case	_	_
12	SCM-1-producer	scm-1-producer	JJ	JJ	_	15	amod	_	_
13	T	t	NN	NN	_	15	compound	_	_
14	cell	cell	NN	NN	_	15	compound	_	_
15	lines	line	NNS	NNS	_	10	nmod	_	_
16	upon	upon	IN	IN	_	17	case	_	_
17	activation	activation	NN	NN	_	9	nmod	_	_
18	was	be	VBD	VBD	_	20	auxpass	_	_
19	completely	completely	RB	RB	_	20	advmod	_	_
20	suppressed	suppress	VBN	VBN	_	0	root	_	_
21	by	by	IN	IN	_	23	case	_	_
22	cyclosporin	cyclosporin	NN	NN	_	23	compound	_	_
23	A	a	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	20	punct	_	_

1	Both	both	DT	DT	_	2	det	_	_
2	complexes	complex	NNS	NNS	_	5	nsubj	_	_
3	were	be	VBD	VBD	_	5	cop	_	_
4	critically	critically	RB	RB	_	5	advmod	_	_
5	dependent	dependent	JJ	JJ	_	0	root	_	_
6	on	on	IN	IN	_	11	case	_	_
7	the	the	DT	DT	_	11	det	_	_
8	NF-AT	nf-at	NN	NN	_	11	compound	_	_
9	core	core	NN	NN	_	11	compound	_	_
10	sequence	sequence	NN	NN	_	11	compound	_	_
11	TTTCC	tttcc	NN	NN	_	5	nmod	_	_
12	in	in	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	E1	e1	NN	NN	_	15	compound	_	_
15	element	element	NN	NN	_	11	nmod	_	_
16	and	and	CC	CC	_	5	cc	_	_
17	were	be	VBD	VBD	_	19	auxpass	_	_
18	partially	partially	RB	RB	_	19	advmod	_	_
19	supershifted	supershift	VBN	VBN	_	5	conj	_	_
20	by	by	IN	IN	_	21	case	_	_
21	anti-NF-ATp	anti-nf-atp	NN	NN	_	19	nmod	_	_
22	.	.	.	.	_	5	punct	_	_

1	One-hybrid	one-hybrid	NN	NN	_	2	compound	_	_
2	assays	assay	NNS	NNS	_	24	nsubj	_	_
3	in	in	IN	IN	_	6	case	_	_
4	yeast	yeast	NN	NN	_	6	compound	_	_
5	isolated	isolate	VBD	VBD	_	6	amod	_	_
6	NF-ATp	nf-atp	NN	NN	_	2	nmod	_	_
7	as	as	IN	IN	_	11	case	_	_
8	an	a	DT	DT	_	11	det	_	_
9	E1	e1	NN	NN	_	11	compound	_	_
10	binding	binding	NN	NN	_	11	compound	_	_
11	protein	protein	NN	NN	_	6	nmod	_	_
12	,	,	,	,	_	2	punct	_	_
13	and	and	CC	CC	_	2	cc	_	_
14	transfection	transfection	NN	NN	_	2	conj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	NF-ATp	nf-atp	NN	NN	_	14	nmod	_	_
17	into	into	IN	IN	_	18	case	_	_
18	T	t	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	18	cc	_	_
20	B	b	NN	NN	_	18	conj	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	18	dep	_	_
23	strongly	strongly	RB	RB	_	24	advmod	_	_
24	enhanced	enhance	VBD	VBD	_	0	root	_	_
25	the	the	DT	DT	_	29	det	_	_
26	activation-dependent	activation-dependent	JJ	JJ	_	29	amod	_	_
27	SCM-1	scm-1	NN	NN	_	29	compound	_	_
28	promoter	promoter	NN	NN	_	29	compound	_	_
29	activity	activity	NN	NN	_	24	dobj	_	_
30	.	.	.	.	_	24	punct	_	_

1	Collectively	collectively	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	a	a	DT	DT	_	5	det	_	_
4	unique	unique	JJ	JJ	_	5	amod	_	_
5	mechanism	mechanism	NN	NN	_	8	nsubj	_	_
6	involving	involve	VBG	VBG	_	7	case	_	_
7	NF-ATp	nf-atp	NN	NN	_	5	nmod	_	_
8	appears	appear	VBZ	VBZ	_	0	root	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	regulate	regulate	VB	VB	_	8	xcomp	_	_
11	the	the	DT	DT	_	16	det	_	_
12	cell	cell	NN	NN	_	13	nmod:npmod	_	_
13	type-specific	type-specific	JJ	JJ	_	16	amod	_	_
14	and	and	CC	CC	_	13	cc	_	_
15	activation-dependent	activation-dependent	JJ	JJ	_	13	conj	_	_
16	expression	expression	NN	NN	_	10	dobj	_	_
17	of	of	IN	IN	_	20	case	_	_
18	the	the	DT	DT	_	20	det	_	_
19	SCM-1	scm-1	NN	NN	_	20	compound	_	_
20	genes	gene	NNS	NNS	_	16	nmod	_	_
21	.	.	.	.	_	8	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	2	nsubj	_	_
2	induce	induce	VBP	VBP	_	9	dep	_	_
3	apoptosis	apoptosis	NN	NN	_	2	dobj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	human	human	JJ	JJ	_	6	amod	_	_
6	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
7	:	:	:	:	_	2	punct	_	_
8	potential	potential	JJ	JJ	_	9	amod	_	_
9	role	role	NN	NN	_	0	root	_	_
10	of	of	IN	IN	_	12	case	_	_
11	IL-1	il-1	NN	NN	_	12	compound	_	_
12	beta	beta	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Glucocorticoids	glucocorticoid	NNS	NNS	_	7	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	GC	gc	NN	NN	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	are	be	VBP	VBP	_	7	cop	_	_
6	potent	potent	JJ	JJ	_	7	amod	_	_
7	anti-inflammatory	anti-inflammatory	JJ	JJ	_	0	root	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	immunosuppressive	immunosuppressive	JJ	JJ	_	7	conj	_	_
10	agents	agent	NNS	NNS	_	7	dep	_	_
11	that	that	WDT	WDT	_	12	nsubj	_	_
12	act	act	VBP	VBP	_	7	acl:relcl	_	_
13	on	on	IN	IN	_	15	case	_	_
14	a	a	DT	DT	_	15	det	_	_
15	variety	variety	NN	NN	_	12	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	immune	immune	JJ	JJ	_	18	amod	_	_
18	cells	cell	NNS	NNS	_	15	nmod	_	_
19	,	,	,	,	_	15	punct	_	_
20	including	include	VBG	VBG	_	21	case	_	_
21	monocytes	monocyte	NNS	NNS	_	15	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	macrophages	macrophage	NNS	NNS	_	21	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	However	however	RB	RB	_	13	advmod	_	_
2	,	,	,	,	_	13	punct	_	_
3	the	the	DT	DT	_	6	det	_	_
4	exact	exact	JJ	JJ	_	6	amod	_	_
5	cellular	cellular	JJ	JJ	_	6	amod	_	_
6	mechanisms	mechanism	NNS	NNS	_	13	nsubj	_	_
7	underlying	underlie	VBG	VBG	_	6	acl	_	_
8	this	this	DT	DT	_	10	det	_	_
9	anti-inflammatory	anti-inflammatory	JJ	JJ	_	10	amod	_	_
10	capacity	capacity	NN	NN	_	7	dobj	_	_
11	are	be	VBP	VBP	_	13	cop	_	_
12	still	still	RB	RB	_	13	advmod	_	_
13	unknown	unknown	JJ	JJ	_	0	root	_	_
14	.	.	.	.	_	13	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	our	we	PRP$	PRP$	_	3	nmod:poss	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	determined	determine	VBD	VBD	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	induction	induction	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	GC	gc	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	6	punct	_	_

1	Peripheral	peripheral	JJ	JJ	_	3	amod	_	_
2	blood	blood	NN	NN	_	3	compound	_	_
3	monocytes	monocyte	NNS	NNS	_	5	nsubjpass	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	isolated	isolate	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	9	case	_	_
7	density	density	NN	NN	_	9	compound	_	_
8	centrifugation	centrifugation	NN	NN	_	9	compound	_	_
9	methods	method	NNS	NNS	_	5	nmod	_	_
10	with	with	IN	IN	_	12	case	_	_
11	a	a	DT	DT	_	12	det	_	_
12	purity	purity	NN	NN	_	9	nmod	_	_
13	of	of	IN	IN	_	16	case	_	_
14	&gt;	&gt;	JJR	JJR	_	15	advmod	_	_
15	90	90	CD	CD	_	16	nummod	_	_
16	%	%	NN	NN	_	12	nmod	_	_
17	and	and	CC	CC	_	5	cc	_	_
18	were	be	VBD	VBD	_	19	auxpass	_	_
19	cultured	culture	VBN	VBN	_	5	conj	_	_
20	in	in	IN	IN	_	23	case	_	_
21	RPMI	rpmi	NN	NN	_	23	compound	_	_
22	1640	1640	CD	CD	_	23	nummod	_	_
23	medium	medium	NN	NN	_	19	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	Monocyte	monocyte	NN	NN	_	2	compound	_	_
2	apoptosis	apoptosis	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	determined	determine	VBN	VBN	_	0	root	_	_
5	by	by	IN	IN	_	8	case	_	_
6	four	four	CD	CD	_	8	nummod	_	_
7	independent	independent	JJ	JJ	_	8	amod	_	_
8	methods	method	NNS	NNS	_	4	nmod	_	_
9	,	,	,	,	_	8	punct	_	_
10	including	include	VBG	VBG	_	12	case	_	_
11	annexin-V	annexin-v	JJ	JJ	_	12	amod	_	_
12	staining	staining	NN	NN	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	TUNEL	tunel	NN	NN	_	12	conj	_	_
15	,	,	,	,	_	12	punct	_	_
16	DNA-laddering	dna-laddering	NN	NN	_	12	conj	_	_
17	,	,	,	,	_	12	punct	_	_
18	and	and	CC	CC	_	12	cc	_	_
19	typical	typical	JJ	JJ	_	20	amod	_	_
20	morphology	morphology	NN	NN	_	12	conj	_	_
21	by	by	IN	IN	_	22	case	_	_
22	means	means	NNS	NNS	_	20	nmod	_	_
23	of	of	IN	IN	_	26	case	_	_
24	transmission	transmission	NN	NN	_	26	compound	_	_
25	electron	electron	NN	NN	_	26	compound	_	_
26	microscopy	microscopy	NN	NN	_	22	nmod	_	_
27	.	.	.	.	_	4	punct	_	_

1	TNF-alpha	tnf-alpha	NN	NN	_	5	nsubjpass	_	_
2	and	and	CC	CC	_	1	cc	_	_
3	IL-1beta	il-1beta	NN	NN	_	1	conj	_	_
4	were	be	VBD	VBD	_	5	auxpass	_	_
5	measured	measure	VBN	VBN	_	0	root	_	_
6	by	by	IN	IN	_	7	case	_	_
7	ELISA	elisa	NN	NN	_	5	nmod	_	_
8	.	.	.	.	_	5	punct	_	_

1	GC	gc	NN	NN	_	2	compound	_	_
2	receptor	receptor	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	blocked	block	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	6	case	_	_
6	mifepristone	mifepristone	NN	NN	_	4	nmod	_	_
7	.	.	.	.	_	4	punct	_	_

1	Caspase	caspase	NN	NN	_	4	nsubjpass	_	_
2	3	3	CD	CD	_	1	nummod	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	inhibited	inhibit	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	7	case	_	_
6	caspase-3	caspase-3	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	DEVD-CHO	devd-cho	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	.	.	.	.	_	4	punct	_	_

1	Stimulation	stimulation	NN	NN	_	8	nsubj	_	_
2	with	with	IN	IN	_	4	case	_	_
3	different	different	JJ	JJ	_	4	amod	_	_
4	GC	gc	NN	NN	_	1	nmod	_	_
5	at	at	IN	IN	_	7	case	_	_
6	therapeutic	therapeutic	JJ	JJ	_	7	amod	_	_
7	concentrations	concentration	NNS	NNS	_	1	nmod	_	_
8	resulted	result	VBD	VBD	_	0	root	_	_
9	in	in	IN	IN	_	11	case	_	_
10	monocyte	monocyte	NN	NN	_	11	compound	_	_
11	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	17	case	_	_
13	a	a	DT	DT	_	17	det	_	_
14	time-	time-	NN	NN	_	17	amod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	dose-dependent	dose-dependent	JJ	JJ	_	14	conj	_	_
17	manner	manner	NN	NN	_	8	nmod	_	_
18	.	.	.	.	_	8	punct	_	_

1	Necrosis	necrosis	NN	NN	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	excluded	exclude	VBN	VBN	_	0	root	_	_
4	by	by	IN	IN	_	7	case	_	_
5	propidium	propidium	NN	NN	_	7	compound	_	_
6	iodide	iodide	NN	NN	_	7	compound	_	_
7	staining	staining	NN	NN	_	3	nmod	_	_
8	.	.	.	.	_	3	punct	_	_

1	Proinflammatory	proinflammatory	JJ	JJ	_	2	amod	_	_
2	cytokines	cytokine	NNS	NNS	_	9	nsubjpass	_	_
3	such	such	JJ	JJ	_	5	case	_	_
4	as	as	IN	IN	_	3	mwe	_	_
5	IL-1beta	il-1beta	NN	NN	_	2	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	TNF-alpha	tnf-alpha	NN	NN	_	5	conj	_	_
8	were	be	VBD	VBD	_	9	auxpass	_	_
9	down-regulated	down-regulate	VBN	VBN	_	0	root	_	_
10	by	by	IN	IN	_	12	case	_	_
11	GC	gc	NN	NN	_	12	compound	_	_
12	treatment	treatment	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	9	punct	_	_

1	Continuous	continuous	JJ	JJ	_	2	amod	_	_
2	treatment	treatment	NN	NN	_	16	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	monocytes	monocyte	NNS	NNS	_	2	nmod	_	_
5	with	with	IN	IN	_	6	case	_	_
6	IL-1beta	il-1beta	NN	NN	_	2	nmod	_	_
7	,	,	,	,	_	6	punct	_	_
8	but	but	CC	CC	_	6	cc	_	_
9	not	not	RB	RB	_	11	neg	_	_
10	with	with	IN	IN	_	11	case	_	_
11	TNF-alpha	tnf-alpha	NN	NN	_	6	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	could	could	MD	MD	_	16	aux	_	_
14	almost	almost	RB	RB	_	15	advmod	_	_
15	completely	completely	RB	RB	_	16	advmod	_	_
16	prevent	prevent	VB	VB	_	0	root	_	_
17	GC-induced	gc-induced	JJ	JJ	_	19	amod	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	death	death	NN	NN	_	16	dobj	_	_
20	.	.	.	.	_	16	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	addition	addition	NN	NN	_	10	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	mifepristone	mifepristone	NN	NN	_	2	nmod	_	_
5	or	or	CC	CC	_	4	cc	_	_
6	caspase-3	caspase-3	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	4	conj	_	_
8	could	could	MD	MD	_	10	aux	_	_
9	partially	partially	RB	RB	_	10	advmod	_	_
10	abrogate	abrogate	VB	VB	_	0	root	_	_
11	GC-induced	gc-induced	JJ	JJ	_	12	amod	_	_
12	apoptosis	apoptosis	NN	NN	_	10	dobj	_	_
13	as	as	RB	RB	_	12	cc	_	_
14	well	well	RB	RB	_	13	mwe	_	_
15	as	as	IN	IN	_	13	mwe	_	_
16	GC-induced	gc-induced	JJ	JJ	_	17	amod	_	_
17	inhibition	inhibition	NN	NN	_	12	conj	_	_
18	of	of	IN	IN	_	19	case	_	_
19	IL-1beta	il-1beta	NN	NN	_	17	nmod	_	_
20	.	.	.	.	_	10	punct	_	_

1	This	this	DT	DT	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	the	the	DT	DT	_	5	det	_	_
4	first	first	JJ	JJ	_	5	amod	_	_
5	study	study	NN	NN	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	demonstrate	demonstrate	VB	VB	_	5	acl	_	_
8	induction	induction	NN	NN	_	7	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	apoptosis	apoptosis	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	12	case	_	_
12	GC	gc	NN	NN	_	8	nmod	_	_
13	in	in	IN	IN	_	15	case	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	monocytes	monocyte	NNS	NNS	_	8	nmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	GC-induced	gc-induced	JJ	JJ	_	3	amod	_	_
2	monocyte	monocyte	NN	NN	_	3	compound	_	_
3	apoptosis	apoptosis	NN	NN	_	7	nsubjpass	_	_
4	may	may	MD	MD	_	7	aux	_	_
5	be	be	VB	VB	_	7	auxpass	_	_
6	partially	partially	RB	RB	_	7	advmod	_	_
7	mediated	mediate	VBN	VBN	_	0	root	_	_
8	through	through	IN	IN	_	9	case	_	_
9	effects	effect	NNS	NNS	_	7	nmod	_	_
10	on	on	IN	IN	_	12	case	_	_
11	IL-1beta	il-1beta	NN	NN	_	12	compound	_	_
12	production	production	NN	NN	_	9	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	It	it	PRP	PRP	_	3	nsubj	_	_
2	is	be	VBZ	VBZ	_	3	cop	_	_
3	conceivable	conceivable	JJ	JJ	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	GC	gc	NN	NN	_	6	nsubj	_	_
6	exert	exert	VBP	VBP	_	3	ccomp	_	_
7	their	they	PRP$	PRP$	_	9	nmod:poss	_	_
8	anti-inflammatory	anti-inflammatory	JJ	JJ	_	9	amod	_	_
9	capacity	capacity	NN	NN	_	6	dobj	_	_
10	in	in	IN	IN	_	12	case	_	_
11	various	various	JJ	JJ	_	12	amod	_	_
12	diseases	disease	NNS	NNS	_	6	nmod	_	_
13	,	,	,	,	_	14	punct	_	_
14	at	at	IN	IN	_	6	dep	_	_
15	least	least	JJS	JJS	_	14	mwe	_	_
16	in	in	IN	IN	_	17	case	_	_
17	part	part	NN	NN	_	14	nmod	_	_
18	,	,	,	,	_	14	punct	_	_
19	by	by	IN	IN	_	21	case	_	_
20	the	the	DT	DT	_	21	det	_	_
21	induction	induction	NN	NN	_	6	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	apoptosis	apoptosis	NN	NN	_	21	nmod	_	_
24	in	in	IN	IN	_	25	case	_	_
25	monocytes	monocyte	NNS	NNS	_	21	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	c-Maf	c-maf	NN	NN	_	0	root	_	_
2	induces	induce	VBZ	VBZ	_	1	dep	_	_
3	monocytic	monocytic	JJ	JJ	_	4	amod	_	_
4	differentiation	differentiation	NN	NN	_	2	dobj	_	_
5	and	and	CC	CC	_	4	cc	_	_
6	apoptosis	apoptosis	NN	NN	_	4	conj	_	_
7	in	in	IN	IN	_	10	case	_	_
8	bipotent	bipotent	JJ	JJ	_	10	amod	_	_
9	myeloid	myeloid	JJ	JJ	_	10	amod	_	_
10	progenitors	progenitor	NNS	NNS	_	2	nmod	_	_
11	.	.	.	.	_	1	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	transcriptional	transcriptional	JJ	JJ	_	3	amod	_	_
3	mechanisms	mechanism	NNS	NNS	_	28	nsubjpass	_	_
4	that	that	WDT	WDT	_	5	nsubj	_	_
5	drive	drive	VBP	VBP	_	3	acl:relcl	_	_
6	colony-forming	colony-forming	JJ	JJ	_	13	amod	_	_
7	unit	unit	NN	NN	_	13	compound	_	_
8	granulocyte-macrophage	granulocyte-macrophage	JJ	JJ	_	13	amod	_	_
9	(	(	-LRB-	-LRB-	_	13	punct	_	_
10	CFU-GM	cfu-gm	NN	NN	_	13	compound	_	_
11	)	)	-RRB-	-RRB-	_	13	punct	_	_
12	myeloid	myeloid	JJ	JJ	_	13	amod	_	_
13	progenitors	progenitor	NNS	NNS	_	5	dobj	_	_
14	to	to	TO	TO	_	15	mark	_	_
15	differentiate	differentiate	VB	VB	_	5	xcomp	_	_
16	into	into	IN	IN	_	17	case	_	_
17	cells	cell	NNS	NNS	_	15	nmod	_	_
18	of	of	IN	IN	_	21	case	_	_
19	either	either	CC	CC	_	21	cc:preconj	_	_
20	the	the	DT	DT	_	21	dep	_	_
21	granulocytic	granulocytic	JJ	JJ	_	17	nmod	_	_
22	or	or	CC	CC	_	21	cc	_	_
23	monocytic	monocytic	JJ	JJ	_	21	conj	_	_
24	lineage	lineage	NN	NN	_	21	dep	_	_
25	are	be	VBP	VBP	_	28	auxpass	_	_
26	not	not	RB	RB	_	28	neg	_	_
27	fully	fully	RB	RB	_	28	advmod	_	_
28	understood	understand	VBN	VBN	_	0	root	_	_
29	.	.	.	.	_	28	punct	_	_

1	We	we	PRP	PRP	_	3	nsubj	_	_
2	have	have	VBP	VBP	_	3	aux	_	_
3	shown	show	VBN	VBN	_	0	root	_	_
4	that	that	IN	IN	_	12	mark	_	_
5	the	the	DT	DT	_	10	det	_	_
6	c-Maf	c-maf	NN	NN	_	10	compound	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	c-Myb	c-myb	NN	NN	_	6	conj	_	_
9	transcription	transcription	NN	NN	_	10	compound	_	_
10	factors	factor	NNS	NNS	_	12	nsubj	_	_
11	physically	physically	RB	RB	_	12	advmod	_	_
12	interact	interact	VBP	VBP	_	3	ccomp	_	_
13	in	in	IN	IN	_	15	case	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	form	form	VB	VB	_	12	xcomp	_	_
18	inhibitory	inhibitory	JJ	JJ	_	19	amod	_	_
19	complexes	complex	NNS	NNS	_	17	dobj	_	_
20	that	that	WDT	WDT	_	21	nsubj	_	_
21	hinder	hinder	VBP	VBP	_	19	acl:relcl	_	_
22	transactivation	transactivation	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	26	case	_	_
24	c-Myb	c-myb	NN	NN	_	26	compound	_	_
25	target	target	NN	NN	_	26	compound	_	_
26	genes	gene	NNS	NNS	_	22	nmod	_	_
27	through	through	IN	IN	_	29	case	_	_
28	direct	direct	JJ	JJ	_	29	amod	_	_
29	binding	binding	NN	NN	_	21	nmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	Myb	myb	NN	NN	_	33	compound	_	_
32	consensus	consensus	NN	NN	_	33	compound	_	_
33	sites	site	NNS	NNS	_	29	nmod	_	_
34	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	complexes	complex	NNS	NNS	_	3	nsubj	_	_
3	arise	arise	VBP	VBP	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	a	a	DT	DT	_	8	det	_	_
6	developmentally	developmentally	RB	RB	_	7	advmod	_	_
7	regulated	regulate	VBN	VBN	_	8	amod	_	_
8	pattern	pattern	NN	NN	_	10	nmod	_	_
9	,	,	,	,	_	10	punct	_	_
10	peaking	peak	VBG	VBG	_	3	xcomp	_	_
11	at	at	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	promyelocyte	promyelocyte	JJ	JJ	_	14	amod	_	_
14	stage	stage	NN	NN	_	10	nmod	_	_
15	,	,	,	,	_	10	punct	_	_
16	or	or	CC	CC	_	10	cc	_	_
17	in	in	IN	IN	_	20	case	_	_
18	cell	cell	NN	NN	_	20	compound	_	_
19	model	model	NN	NN	_	20	compound	_	_
20	systems	system	NNS	NNS	_	22	nmod	_	_
21	,	,	,	,	_	22	punct	_	_
22	appearing	appear	VBG	VBG	_	10	conj	_	_
23	soon	soon	RB	RB	_	22	advcl	_	_
24	after	after	IN	IN	_	26	case	_	_
25	the	the	DT	DT	_	26	det	_	_
26	induction	induction	NN	NN	_	23	nmod	_	_
27	of	of	IN	IN	_	29	case	_	_
28	monocytic	monocytic	JJ	JJ	_	29	amod	_	_
29	differentiation	differentiation	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	wished	wish	VBD	VBD	_	0	root	_	_
3	to	to	TO	TO	_	4	mark	_	_
4	determine	determine	VB	VB	_	2	xcomp	_	_
5	if	if	IN	IN	_	12	mark	_	_
6	this	this	DT	DT	_	9	det	_	_
7	developmentally	developmentally	RB	RB	_	8	advmod	_	_
8	related	related	JJ	JJ	_	9	amod	_	_
9	interaction	interaction	NN	NN	_	12	nsubj	_	_
10	is	be	VBZ	VBZ	_	12	cop	_	_
11	a	a	DT	DT	_	12	det	_	_
12	consequence	consequence	NN	NN	_	4	advcl	_	_
13	of	of	IN	IN	_	15	case	_	_
14	myeloid	myeloid	JJ	JJ	_	15	amod	_	_
15	differentiation	differentiation	NN	NN	_	12	nmod	_	_
16	or	or	CC	CC	_	12	cc	_	_
17	an	a	DT	DT	_	20	det	_	_
18	intrinsic	intrinsic	JJ	JJ	_	20	amod	_	_
19	differentiating	differentiate	VBG	VBG	_	20	amod	_	_
20	stimulus	stimulus	NN	NN	_	12	conj	_	_
21	.	.	.	.	_	2	punct	_	_

1	Because	because	IN	IN	_	14	mark	_	_
2	the	the	DT	DT	_	7	det	_	_
3	elevated	elevated	JJ	JJ	_	7	amod	_	_
4	Myb	myb	NN	NN	_	7	compound	_	_
5	:	:	:	:	_	7	punct	_	_
6	Maf	maf	NN	NN	_	7	compound	_	_
7	status	status	NN	NN	_	14	nsubjpass	_	_
8	seen	see	VBN	VBN	_	7	acl	_	_
9	in	in	IN	IN	_	11	case	_	_
10	differentiating	differentiate	VBG	VBG	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	can	can	MD	MD	_	14	aux	_	_
13	be	be	VB	VB	_	14	auxpass	_	_
14	recapitulated	recapitulate	VBN	VBN	_	26	advcl	_	_
15	by	by	IN	IN	_	16	case	_	_
16	overexpression	overexpression	NN	NN	_	14	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	c-Maf	c-maf	NN	NN	_	16	nmod	_	_
19	in	in	IN	IN	_	22	case	_	_
20	myeloid	myeloid	JJ	JJ	_	22	amod	_	_
21	cell	cell	NN	NN	_	22	compound	_	_
22	lines	line	NNS	NNS	_	16	nmod	_	_
23	,	,	,	,	_	26	punct	_	_
24	we	we	PRP	PRP	_	26	nsubj	_	_
25	inducibly	inducibly	RB	RB	_	26	advmod	_	_
26	expressed	express	VBD	VBD	_	0	root	_	_
27	the	the	DT	DT	_	29	det	_	_
28	c-Maf	c-maf	NN	NN	_	29	compound	_	_
29	cDNA	cdna	NN	NN	_	26	dobj	_	_
30	in	in	IN	IN	_	36	case	_	_
31	2	2	CD	CD	_	36	nummod	_	_
32	bipotent	bipotent	JJ	JJ	_	36	amod	_	_
33	human	human	JJ	JJ	_	36	amod	_	_
34	myeloid	myeloid	JJ	JJ	_	36	amod	_	_
35	progenitor	progenitor	NN	NN	_	36	compound	_	_
36	cells	cell	NNS	NNS	_	26	nmod	_	_
37	.	.	.	.	_	26	punct	_	_

1	Elevated	elevated	JJ	JJ	_	2	amod	_	_
2	levels	level	NNS	NNS	_	6	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	c-Maf	c-maf	NN	NN	_	5	compound	_	_
5	protein	protein	NN	NN	_	2	nmod	_	_
6	led	lead	VBD	VBD	_	0	root	_	_
7	to	to	TO	TO	_	9	case	_	_
8	marked	marked	JJ	JJ	_	9	amod	_	_
9	increases	increase	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	14	case	_	_
11	Myb	myb	NN	NN	_	14	compound	_	_
12	:	:	:	:	_	14	punct	_	_
13	Maf	maf	NN	NN	_	14	compound	_	_
14	complexes	complex	NNS	NNS	_	9	nmod	_	_
15	and	and	CC	CC	_	9	cc	_	_
16	the	the	DT	DT	_	17	det	_	_
17	accumulation	accumulation	NN	NN	_	9	conj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	monocyte/macrophage	monocyte/macrophage	JJ	JJ	_	20	amod	_	_
20	cells	cell	NNS	NNS	_	17	nmod	_	_
21	,	,	,	,	_	9	punct	_	_
22	followed	follow	VBN	VBN	_	6	dep	_	_
23	by	by	IN	IN	_	27	case	_	_
24	eventual	eventual	JJ	JJ	_	27	amod	_	_
25	programmed	program	VBN	VBN	_	27	amod	_	_
26	cell	cell	NN	NN	_	27	compound	_	_
27	death	death	NN	NN	_	22	nmod	_	_
28	.	.	.	.	_	6	punct	_	_

1	Analysis	analysis	NN	NN	_	10	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	targets	target	NNS	NNS	_	1	nmod	_	_
4	that	that	WDT	WDT	_	6	nsubj	_	_
5	could	could	MD	MD	_	6	aux	_	_
6	mediate	mediate	VB	VB	_	3	acl:relcl	_	_
7	these	these	DT	DT	_	9	det	_	_
8	phenotypic	phenotypic	JJ	JJ	_	9	amod	_	_
9	changes	change	NNS	NNS	_	6	dobj	_	_
10	indicated	indicate	VBD	VBD	_	0	root	_	_
11	that	that	IN	IN	_	14	mark	_	_
12	c-Maf	c-maf	NN	NN	_	14	nsubj	_	_
13	likely	likely	RB	RB	_	14	advmod	_	_
14	plays	play	VBZ	VBZ	_	10	ccomp	_	_
15	a	a	DT	DT	_	17	det	_	_
16	key	key	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	21	case	_	_
19	myeloid	myeloid	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	development	development	NN	NN	_	14	nmod	_	_
22	through	through	IN	IN	_	24	case	_	_
23	dual	dual	JJ	JJ	_	24	amod	_	_
24	mechanisms	mechanism	NNS	NNS	_	14	nmod	_	_
25	;	;	:	:	_	24	punct	_	_
26	inhibition	inhibition	NN	NN	_	24	dep	_	_
27	of	of	IN	IN	_	30	case	_	_
28	a	a	DT	DT	_	30	det	_	_
29	select	select	JJ	JJ	_	30	amod	_	_
30	set	set	NN	NN	_	26	nmod	_	_
31	of	of	IN	IN	_	34	case	_	_
32	c-Myb	c-myb	NN	NN	_	34	compound	_	_
33	regulated	regulated	JJ	JJ	_	34	amod	_	_
34	targets	target	NNS	NNS	_	30	nmod	_	_
35	,	,	,	,	_	34	punct	_	_
36	such	such	JJ	JJ	_	38	case	_	_
37	as	as	IN	IN	_	38	case	_	_
38	Bcl-2	bcl-2	NN	NN	_	34	nmod	_	_
39	and	and	CC	CC	_	38	cc	_	_
40	CD13/APN	cd13/apn	NN	NN	_	38	conj	_	_
41	,	,	,	,	_	26	punct	_	_
42	coupled	couple	VBN	VBN	_	26	acl	_	_
43	with	with	IN	IN	_	45	case	_	_
44	the	the	DT	DT	_	45	det	_	_
45	activation	activation	NN	NN	_	42	nmod	_	_
46	of	of	IN	IN	_	51	case	_	_
47	as	as	RB	RB	_	49	advmod	_	_
48	yet	yet	RB	RB	_	49	advmod	_	_
49	undefined	undefined	JJ	JJ	_	51	amod	_	_
50	differentiation-promoting	differentiation-promoting	JJ	JJ	_	51	amod	_	_
51	genes	gene	NNS	NNS	_	45	nmod	_	_
52	.	.	.	.	_	10	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	3	amod	_	_
2	factor-kappaB-dependent	factor-kappab-dependent	JJ	JJ	_	3	amod	_	_
3	induction	induction	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	interleukin-8	interleukin-8	NN	NN	_	7	compound	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	3	nmod	_	_
8	by	by	IN	IN	_	12	case	_	_
9	tumor	tumor	NN	NN	_	12	compound	_	_
10	necrosis	necrosis	NN	NN	_	12	compound	_	_
11	factor	factor	NN	NN	_	12	compound	_	_
12	alpha	alpha	NN	NN	_	3	nmod	_	_
13	:	:	:	:	_	3	punct	_	_
14	evidence	evidence	NN	NN	_	3	dep	_	_
15	for	for	IN	IN	_	20	case	_	_
16	an	a	DT	DT	_	20	det	_	_
17	antioxidant	antioxidant	JJ	JJ	_	20	amod	_	_
18	sensitive	sensitive	JJ	JJ	_	20	amod	_	_
19	activating	activating	NN	NN	_	20	compound	_	_
20	pathway	pathway	NN	NN	_	14	nmod	_	_
21	distinct	distinct	JJ	JJ	_	20	amod	_	_
22	from	from	IN	IN	_	24	case	_	_
23	nuclear	nuclear	JJ	JJ	_	24	amod	_	_
24	translocation	translocation	NN	NN	_	21	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Tumor	tumor	NN	NN	_	4	compound	_	_
2	necrosis	necrosis	NN	NN	_	4	compound	_	_
3	factor	factor	NN	NN	_	4	compound	_	_
4	alpha	alpha	NN	NN	_	13	nsubj	_	_
5	(	(	-LRB-	-LRB-	_	6	punct	_	_
6	TNFalpha	tnfalpha	NN	NN	_	4	appos	_	_
7	)	)	-RRB-	-RRB-	_	6	punct	_	_
8	is	be	VBZ	VBZ	_	13	cop	_	_
9	a	a	DT	DT	_	13	det	_	_
10	pluripotent	pluripotent	JJ	JJ	_	13	amod	_	_
11	activator	activator	NN	NN	_	13	compound	_	_
12	of	of	IN	IN	_	13	amod	_	_
13	inflammation	inflammation	NN	NN	_	0	root	_	_
14	by	by	IN	IN	_	15	mark	_	_
15	inducing	induce	VBG	VBG	_	13	acl	_	_
16	a	a	DT	DT	_	19	det	_	_
17	proinflammatory	proinflammatory	JJ	JJ	_	19	amod	_	_
18	cytokine	cytokine	NN	NN	_	19	compound	_	_
19	cascade	cascade	NN	NN	_	15	dobj	_	_
20	.	.	.	.	_	13	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	phenomenon	phenomenon	NN	NN	_	4	nsubjpass	_	_
3	is	be	VBZ	VBZ	_	4	auxpass	_	_
4	mediated	mediate	VBN	VBN	_	0	root	_	_
5	,	,	,	,	_	4	punct	_	_
6	in	in	IN	IN	_	7	case	_	_
7	part	part	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	through	through	IN	IN	_	11	case	_	_
10	inducible	inducible	JJ	JJ	_	11	amod	_	_
11	expression	expression	NN	NN	_	4	nmod	_	_
12	of	of	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	CXC	cxc	NN	NN	_	15	compound	_	_
15	chemokine	chemokine	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	interleukin-8	interleukin-8	NN	NN	_	15	appos	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	IL-8	il-8	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	investigate	investigate	VBP	VBP	_	0	root	_	_
7	the	the	DT	DT	_	8	det	_	_
8	role	role	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	13	case	_	_
10	TNFalpha-inducible	tnfalpha-inducible	JJ	JJ	_	13	amod	_	_
11	reactive	reactive	JJ	JJ	_	13	amod	_	_
12	oxygen	oxygen	NN	NN	_	13	compound	_	_
13	species	species	NNS	NNS	_	8	nmod	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	ROS	ros	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	in	in	IN	IN	_	19	case	_	_
18	IL-8	il-8	NN	NN	_	19	compound	_	_
19	expression	expression	NN	NN	_	8	nmod	_	_
20	by	by	IN	IN	_	26	case	_	_
21	``	``	``	``	_	26	punct	_	_
22	monocyte-like	monocyte-like	JJ	JJ	_	26	amod	_	_
23	U937	u937	NN	NN	_	26	compound	_	_
24	histiocytic	histiocytic	JJ	JJ	_	26	amod	_	_
25	lymphoma	lymphoma	NN	NN	_	26	compound	_	_
26	cells	cell	NNS	NNS	_	19	nmod	_	_
27	.	.	.	.	_	6	punct	_	_

1	TNFalpha	tnfalpha	NN	NN	_	5	nsubj	_	_
2	is	be	VBZ	VBZ	_	5	cop	_	_
3	a	a	DT	DT	_	5	det	_	_
4	rapid	rapid	JJ	JJ	_	5	amod	_	_
5	activator	activator	NN	NN	_	0	root	_	_
6	of	of	IN	IN	_	9	case	_	_
7	IL-8	il-8	NN	NN	_	9	compound	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	U937	u937	NN	NN	_	9	nmod	_	_
12	,	,	,	,	_	5	punct	_	_
13	producing	produce	VBG	VBG	_	5	dep	_	_
14	a	a	DT	DT	_	16	det	_	_
15	50-fold	50-fold	JJ	JJ	_	16	amod	_	_
16	induction	induction	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	mRNA	mrna	NN	NN	_	16	nmod	_	_
19	within	within	IN	IN	_	21	case	_	_
20	1	1	CD	CD	_	21	nummod	_	_
21	hour	hour	NN	NN	_	13	nmod	_	_
22	of	of	IN	IN	_	23	case	_	_
23	treatment	treatment	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	5	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	gene	gene	NN	NN	_	4	compound	_	_
3	transfection	transfection	NN	NN	_	4	compound	_	_
4	assays	assay	NNS	NNS	_	10	nmod	_	_
5	,	,	,	,	_	10	punct	_	_
6	the	the	DT	DT	_	7	det	_	_
7	effect	effect	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	TNFalpha	tnfalpha	NN	NN	_	7	nmod	_	_
10	requires	require	VBZ	VBZ	_	0	root	_	_
11	the	the	DT	DT	_	12	det	_	_
12	presence	presence	NN	NN	_	10	dobj	_	_
13	of	of	IN	IN	_	26	case	_	_
14	an	a	DT	DT	_	26	det	_	_
15	inducible	inducible	JJ	JJ	_	26	amod	_	_
16	nuclear	nuclear	JJ	JJ	_	26	amod	_	_
17	factor-kappaB	factor-kappab	NN	NN	_	26	compound	_	_
18	(	(	-LRB-	-LRB-	_	26	punct	_	_
19	NF-kappaB	nf-kappab	NN	NN	_	26	compound	_	_
20	)	)	-RRB-	-RRB-	_	26	punct	_	_
21	(	(	-LRB-	-LRB-	_	26	punct	_	_
22	Rel	rel	NN	NN	_	26	compound	_	_
23	A	a	NN	NN	_	26	compound	_	_
24	)	)	-RRB-	-RRB-	_	26	punct	_	_
25	binding	binding	NN	NN	_	26	compound	_	_
26	site	site	NN	NN	_	12	nmod	_	_
27	in	in	IN	IN	_	30	case	_	_
28	the	the	DT	DT	_	30	det	_	_
29	IL-8	il-8	NN	NN	_	30	compound	_	_
30	promoter	promoter	NN	NN	_	12	nmod	_	_
31	.	.	.	.	_	10	punct	_	_

1	TNFalpha	tnfalpha	NN	NN	_	2	compound	_	_
2	treatment	treatment	NN	NN	_	3	nsubj	_	_
3	induces	induce	VBZ	VBZ	_	0	root	_	_
4	a	a	DT	DT	_	6	det	_	_
5	rapid	rapid	JJ	JJ	_	6	amod	_	_
6	translocation	translocation	NN	NN	_	3	dobj	_	_
7	of	of	IN	IN	_	14	case	_	_
8	the	the	DT	DT	_	14	det	_	_
9	65	65	CD	CD	_	14	nummod	_	_
10	kD	kd	NN	NN	_	14	compound	_	_
11	transcriptional	transcriptional	JJ	JJ	_	14	amod	_	_
12	activator	activator	NN	NN	_	14	compound	_	_
13	NF-kappaB	nf-kappab	NN	NN	_	14	compound	_	_
14	subunit	subunit	NN	NN	_	6	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	Rel	rel	NN	NN	_	17	compound	_	_
17	A	a	NN	NN	_	14	appos	_	_
18	,	,	,	,	_	14	punct	_	_
19	whose	whose	WP$	WP$	_	20	nmod:poss	_	_
20	binding	binding	NN	NN	_	24	nsubj	_	_
21	in	in	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	nucleus	nucleus	NN	NN	_	20	nmod	_	_
24	occurs	occur	VBZ	VBZ	_	14	acl:relcl	_	_
25	before	before	IN	IN	_	26	case	_	_
26	changes	change	NNS	NNS	_	24	nmod	_	_
27	in	in	IN	IN	_	29	case	_	_
28	intracellular	intracellular	JJ	JJ	_	29	amod	_	_
29	ROS	ros	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	28	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	8	punct	_	_
3	or	or	CC	CC	_	8	cc	_	_
4	up	up	IN	IN	_	6	dep	_	_
5	to	to	TO	TO	_	4	mwe	_	_
6	15	15	CD	CD	_	7	nummod	_	_
7	minutes	minute	NNS	NNS	_	8	compound	_	_
8	posttreatment	posttreatment	NN	NN	_	1	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	relative	relative	JJ	JJ	_	1	amod	_	_
11	to	to	TO	TO	_	12	case	_	_
12	TNFalpha	tnfalpha	NN	NN	_	10	nmod	_	_
13	with	with	IN	IN	_	17	case	_	_
14	the	the	DT	DT	_	17	det	_	_
15	antioxidant	antioxidant	JJ	JJ	_	17	amod	_	_
16	dimethyl	dimethyl	NN	NN	_	17	compound	_	_
17	sulfoxide	sulfoxide	NN	NN	_	1	nmod	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	DMSO	dmso	NN	NN	_	17	appos	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	(	(	-LRB-	-LRB-	_	23	punct	_	_
22	2	2	CD	CD	_	23	nummod	_	_
23	%	%	NN	NN	_	17	dep	_	_
24	-LSB-	-lsb-	-LRB-	-LRB-	_	25	punct	_	_
25	vol/vol	vol/vol	NN	NN	_	23	appos	_	_
26	-RSB-	-rsb-	-RRB-	-RRB-	_	25	punct	_	_
27	)	)	-RRB-	-RRB-	_	23	punct	_	_
28	blocks	block	VBZ	VBZ	_	0	root	_	_
29	80	80	CD	CD	_	30	nummod	_	_
30	%	%	NN	NN	_	28	dobj	_	_
31	of	of	IN	IN	_	33	case	_	_
32	NF-kappaB-dependent	nf-kappab-dependent	JJ	JJ	_	33	amod	_	_
33	transcription	transcription	NN	NN	_	30	nmod	_	_
34	.	.	.	.	_	28	punct	_	_

1	Surprisingly	surprisingly	RB	RB	_	6	advmod	_	_
2	,	,	,	,	_	6	punct	_	_
3	however	however	RB	RB	_	6	advmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	DMSO	dmso	NN	NN	_	6	nsubj	_	_
6	has	have	VBZ	VBZ	_	0	root	_	_
7	no	no	DT	DT	_	8	neg	_	_
8	effect	effect	NN	NN	_	6	dobj	_	_
9	on	on	IN	IN	_	13	case	_	_
10	inducible	inducible	JJ	JJ	_	13	amod	_	_
11	Rel	rel	NN	NN	_	13	compound	_	_
12	A	a	NN	NN	_	13	compound	_	_
13	binding	binding	NN	NN	_	6	nmod	_	_
14	.	.	.	.	_	6	punct	_	_

1	Similar	similar	JJ	JJ	_	3	amod	_	_
2	selective	selective	JJ	JJ	_	3	amod	_	_
3	effects	effect	NNS	NNS	_	8	nsubjpass	_	_
4	on	on	IN	IN	_	6	case	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	transcription	transcription	NN	NN	_	3	nmod	_	_
7	are	be	VBP	VBP	_	8	auxpass	_	_
8	seen	see	VBN	VBN	_	0	root	_	_
9	with	with	IN	IN	_	12	case	_	_
10	the	the	DT	DT	_	12	det	_	_
11	unrelated	unrelated	JJ	JJ	_	12	amod	_	_
12	antioxidants	antioxidant	NNS	NNS	_	8	nmod	_	_
13	,	,	,	,	_	12	punct	_	_
14	N-acetylcysteine	n-acetylcysteine	NN	NN	_	12	appos	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	NAC	nac	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	vitamin	vitamin	NN	NN	_	20	compound	_	_
20	C	c	NN	NN	_	14	conj	_	_
21	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	indicate	indicate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	TNFalpha	tnfalpha	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	a	a	DT	DT	_	11	det	_	_
8	delayed	delay	VBN	VBN	_	11	amod	_	_
9	ROS-dependent	ros-dependent	JJ	JJ	_	11	amod	_	_
10	signalling	signalling	NN	NN	_	11	compound	_	_
11	pathway	pathway	NN	NN	_	6	dobj	_	_
12	that	that	WDT	WDT	_	14	nsubjpass	_	_
13	is	be	VBZ	VBZ	_	14	auxpass	_	_
14	required	require	VBN	VBN	_	11	acl:relcl	_	_
15	for	for	IN	IN	_	18	case	_	_
16	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
17	transcriptional	transcriptional	JJ	JJ	_	18	amod	_	_
18	activation	activation	NN	NN	_	14	nmod	_	_
19	and	and	CC	CC	_	14	cc	_	_
20	is	be	VBZ	VBZ	_	21	cop	_	_
21	separable	separable	JJ	JJ	_	14	conj	_	_
22	from	from	IN	IN	_	23	case	_	_
23	that	that	DT	DT	_	21	nmod	_	_
24	required	require	VBN	VBN	_	23	acl	_	_
25	for	for	IN	IN	_	28	case	_	_
26	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
27	nuclear	nuclear	JJ	JJ	_	28	amod	_	_
28	translocation	translocation	NN	NN	_	24	nmod	_	_
29	.	.	.	.	_	3	punct	_	_

1	Further	further	RB	RB	_	2	advmod	_	_
2	definition	definition	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	5	case	_	_
4	this	this	DT	DT	_	5	det	_	_
5	pathway	pathway	NN	NN	_	2	nmod	_	_
6	will	will	MD	MD	_	7	aux	_	_
7	yield	yield	VB	VB	_	0	root	_	_
8	new	new	JJ	JJ	_	9	amod	_	_
9	insights	insight	NNS	NNS	_	7	dobj	_	_
10	into	into	IN	IN	_	11	case	_	_
11	inflammation	inflammation	NN	NN	_	7	nmod	_	_
12	initiated	initiate	VBN	VBN	_	11	acl	_	_
13	by	by	IN	IN	_	15	case	_	_
14	TNFalpha	tnfalpha	NN	NN	_	15	compound	_	_
15	signalling	signalling	NN	NN	_	12	nmod	_	_
16	.	.	.	.	_	7	punct	_	_

1	Peroxisome	peroxisome	NN	NN	_	4	compound	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	4	amod	_	_
3	receptor	receptor	NN	NN	_	4	compound	_	_
4	activators	activator	NNS	NNS	_	5	nsubj	_	_
5	target	target	VBP	VBP	_	0	root	_	_
6	human	human	JJ	JJ	_	8	amod	_	_
7	endothelial	endothelial	JJ	JJ	_	8	amod	_	_
8	cells	cell	NNS	NNS	_	5	dobj	_	_
9	to	to	TO	TO	_	10	mark	_	_
10	inhibit	inhibit	VB	VB	_	5	advcl	_	_
11	leukocyte-endothelial	leukocyte-endothelial	JJ	JJ	_	13	amod	_	_
12	cell	cell	NN	NN	_	13	compound	_	_
13	interaction	interaction	NN	NN	_	10	dobj	_	_
14	.	.	.	.	_	5	punct	_	_

1	An	a	DT	DT	_	3	det	_	_
2	early	early	JJ	JJ	_	3	amod	_	_
3	event	event	NN	NN	_	21	nsubj	_	_
4	in	in	IN	IN	_	5	case	_	_
5	acute	acute	JJ	JJ	_	3	nmod	_	_
6	and	and	CC	CC	_	5	cc	_	_
7	chronic	chronic	JJ	JJ	_	5	conj	_	_
8	inflammation	inflammation	NN	NN	_	5	dep	_	_
9	and	and	CC	CC	_	5	cc	_	_
10	associated	associate	VBN	VBN	_	11	amod	_	_
11	diseases	disease	NNS	NNS	_	5	conj	_	_
12	such	such	JJ	JJ	_	14	case	_	_
13	as	as	IN	IN	_	14	case	_	_
14	atherosclerosis	atherosclerosis	NN	NN	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	rheumatoid	rheumatoid	JJ	JJ	_	17	amod	_	_
17	arthritis	arthritis	NN	NN	_	14	conj	_	_
18	is	be	VBZ	VBZ	_	21	cop	_	_
19	the	the	DT	DT	_	21	det	_	_
20	induced	induce	VBN	VBN	_	21	amod	_	_
21	expression	expression	NN	NN	_	0	root	_	_
22	of	of	IN	IN	_	25	case	_	_
23	specific	specific	JJ	JJ	_	25	amod	_	_
24	adhesion	adhesion	NN	NN	_	25	compound	_	_
25	molecules	molecule	NNS	NNS	_	21	nmod	_	_
26	on	on	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	surface	surface	NN	NN	_	21	nmod	_	_
29	of	of	IN	IN	_	31	case	_	_
30	endothelial	endothelial	JJ	JJ	_	31	amod	_	_
31	cells	cell	NNS	NNS	_	28	nmod	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	ECs	ec	NNS	NNS	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	31	punct	_	_
36	which	which	WDT	WDT	_	38	nsubj	_	_
37	subsequently	subsequently	RB	RB	_	38	advmod	_	_
38	bind	bind	VBP	VBP	_	31	acl:relcl	_	_
39	leukocytes	leukocyte	NNS	NNS	_	38	dobj	_	_
40	.	.	.	.	_	21	punct	_	_

1	Peroxisome	peroxisome	NN	NN	_	3	compound	_	_
2	proliferator-activated	proliferator-activated	JJ	JJ	_	3	amod	_	_
3	receptors	receptor	NNS	NNS	_	19	nsubjpass	_	_
4	(	(	-LRB-	-LRB-	_	5	punct	_	_
5	PPARs	ppar	NNS	NNS	_	3	appos	_	_
6	)	)	-RRB-	-RRB-	_	5	punct	_	_
7	,	,	,	,	_	3	punct	_	_
8	members	member	NNS	NNS	_	3	appos	_	_
9	of	of	IN	IN	_	13	case	_	_
10	the	the	DT	DT	_	13	det	_	_
11	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	superfamily	superfamily	NN	NN	_	8	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	transcription	transcription	NN	NN	_	16	compound	_	_
16	factors	factor	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	3	punct	_	_
18	are	be	VBP	VBP	_	19	auxpass	_	_
19	activated	activate	VBN	VBN	_	0	root	_	_
20	by	by	IN	IN	_	23	case	_	_
21	fatty	fatty	JJ	JJ	_	23	amod	_	_
22	acid	acid	JJ	JJ	_	23	amod	_	_
23	metabolites	metabolite	NNS	NNS	_	19	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	peroxisome	peroxisome	NN	NN	_	26	compound	_	_
26	proliferators	proliferator	NNS	NNS	_	23	conj	_	_
27	,	,	,	,	_	23	punct	_	_
28	and	and	CC	CC	_	23	cc	_	_
29	thiazolidinediones	thiazolidinedione	NNS	NNS	_	23	conj	_	_
30	and	and	CC	CC	_	19	cc	_	_
31	are	be	VBP	VBP	_	33	auxpass	_	_
32	now	now	RB	RB	_	33	advmod	_	_
33	recognized	recognize	VBN	VBN	_	19	conj	_	_
34	as	as	RB	RB	_	36	advmod	_	_
35	important	important	JJ	JJ	_	36	amod	_	_
36	mediators	mediator	NNS	NNS	_	33	nmod	_	_
37	in	in	IN	IN	_	40	case	_	_
38	the	the	DT	DT	_	40	det	_	_
39	inflammatory	inflammatory	JJ	JJ	_	40	amod	_	_
40	response	response	NN	NN	_	36	nmod	_	_
41	.	.	.	.	_	19	punct	_	_

1	Whether	whether	IN	IN	_	4	mark	_	_
2	PPAR	ppar	NN	NN	_	3	compound	_	_
3	activators	activator	NNS	NNS	_	4	nsubj	_	_
4	influence	influence	VBP	VBP	_	11	csubj	_	_
5	the	the	DT	DT	_	7	det	_	_
6	inflammatory	inflammatory	JJ	JJ	_	7	amod	_	_
7	responses	response	NNS	NNS	_	4	dobj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	ECs	ec	NNS	NNS	_	7	nmod	_	_
10	is	be	VBZ	VBZ	_	11	cop	_	_
11	unknown	unknown	JJ	JJ	_	0	root	_	_
12	.	.	.	.	_	11	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	39	mark	_	_
4	the	the	DT	DT	_	6	det	_	_
5	PPAR	ppar	NN	NN	_	6	compound	_	_
6	activators	activator	NNS	NNS	_	39	nsubj	_	_
7	15-deoxy-Delta	15-deoxy-delta	NN	NN	_	14	compound	_	_
8	(	(	-LRB-	-LRB-	_	14	punct	_	_
9	12	12	CD	CD	_	14	nummod	_	_
10	,	,	,	,	_	14	punct	_	_
11	14	14	CD	CD	_	14	nummod	_	_
12	)	)	-RRB-	-RRB-	_	14	punct	_	_
13	-prostaglandin	-prostaglandin	NN	NN	_	14	compound	_	_
14	J	j	NN	NN	_	6	dep	_	_
15	(	(	-LRB-	-LRB-	_	14	punct	_	_
16	2	2	CD	CD	_	14	nummod	_	_
17	)	)	-RRB-	-RRB-	_	14	punct	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	15d-PGJ	15d-pgj	NN	NN	_	14	appos	_	_
20	(	(	-LRB-	-LRB-	_	19	punct	_	_
21	2	2	CD	CD	_	19	nummod	_	_
22	)	)	-RRB-	-RRB-	_	19	punct	_	_
23	)	)	-RRB-	-RRB-	_	19	punct	_	_
24	,	,	,	,	_	14	punct	_	_
25	Wyeth	wyeth	NN	NN	_	14	conj	_	_
26	14643	14643	CD	CD	_	25	nummod	_	_
27	,	,	,	,	_	14	punct	_	_
28	ciglitazone	ciglitazone	NN	NN	_	14	conj	_	_
29	,	,	,	,	_	14	punct	_	_
30	and	and	CC	CC	_	14	cc	_	_
31	troglitazone	troglitazone	NN	NN	_	14	conj	_	_
32	,	,	,	,	_	14	punct	_	_
33	but	but	CC	CC	_	14	cc	_	_
34	not	not	RB	RB	_	35	neg	_	_
35	BRL	brl	NN	NN	_	14	conj	_	_
36	49653	49653	CD	CD	_	35	nummod	_	_
37	,	,	,	,	_	14	punct	_	_
38	partially	partially	RB	RB	_	39	advmod	_	_
39	inhibit	inhibit	VBP	VBP	_	2	ccomp	_	_
40	the	the	DT	DT	_	42	det	_	_
41	induced	induce	VBN	VBN	_	42	amod	_	_
42	expression	expression	NN	NN	_	39	dobj	_	_
43	of	of	IN	IN	_	47	case	_	_
44	vascular	vascular	JJ	JJ	_	47	amod	_	_
45	cell	cell	NN	NN	_	47	compound	_	_
46	adhesion	adhesion	NN	NN	_	47	compound	_	_
47	molecule-1	molecule-1	NN	NN	_	42	nmod	_	_
48	(	(	-LRB-	-LRB-	_	49	punct	_	_
49	VCAM-1	vcam-1	NN	NN	_	47	appos	_	_
50	)	)	-RRB-	-RRB-	_	49	punct	_	_
51	,	,	,	,	_	53	punct	_	_
52	as	as	IN	IN	_	53	mark	_	_
53	measured	measure	VBN	VBN	_	42	dep	_	_
54	by	by	IN	IN	_	55	case	_	_
55	ELISA	elisa	NN	NN	_	53	nmod	_	_
56	,	,	,	,	_	53	punct	_	_
57	and	and	CC	CC	_	42	cc	_	_
58	monocyte	monocyte	NN	NN	_	42	conj	_	_
59	binding	bind	VBG	VBG	_	58	amod	_	_
60	to	to	TO	TO	_	64	case	_	_
61	human	human	JJ	JJ	_	64	amod	_	_
62	aortic	aortic	JJ	JJ	_	64	amod	_	_
63	endothelial	endothelial	JJ	JJ	_	64	amod	_	_
64	cells	cell	NNS	NNS	_	58	nmod	_	_
65	(	(	-LRB-	-LRB-	_	66	punct	_	_
66	HAECs	haec	NNS	NNS	_	64	appos	_	_
67	)	)	-RRB-	-RRB-	_	66	punct	_	_
68	activated	activate	VBN	VBN	_	64	acl	_	_
69	by	by	IN	IN	_	72	case	_	_
70	phorbol	phorbol	NN	NN	_	72	compound	_	_
71	12-myristate	12-myristate	NN	NN	_	72	compound	_	_
72	13-acetate	13-acetate	NN	NN	_	68	nmod	_	_
73	(	(	-LRB-	-LRB-	_	74	punct	_	_
74	PMA	pma	NN	NN	_	72	appos	_	_
75	)	)	-RRB-	-RRB-	_	74	punct	_	_
76	or	or	CC	CC	_	72	cc	_	_
77	lipopolysaccharide	lipopolysaccharide	NN	NN	_	72	conj	_	_
78	.	.	.	.	_	2	punct	_	_

1	The	the	DT	DT	_	6	det	_	_
2	``	``	``	``	_	6	punct	_	_
3	natural	natural	JJ	JJ	_	6	amod	_	_
4	PPAR	ppar	NN	NN	_	6	compound	_	_
5	activator	activator	NN	NN	_	6	compound	_	_
6	15d-PGJ	15d-pgj	NN	NN	_	10	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	6	punct	_	_
8	2	2	CD	CD	_	6	nummod	_	_
9	)	)	-RRB-	-RRB-	_	6	punct	_	_
10	had	have	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	13	det	_	_
12	greatest	greatest	JJS	JJS	_	13	amod	_	_
13	potency	potency	NN	NN	_	10	dobj	_	_
14	and	and	CC	CC	_	10	cc	_	_
15	was	be	VBD	VBD	_	19	cop	_	_
16	the	the	DT	DT	_	19	det	_	_
17	only	only	RB	RB	_	19	advmod	_	_
18	tested	test	VBN	VBN	_	19	amod	_	_
19	molecule	molecule	NN	NN	_	10	conj	_	_
20	capable	capable	JJ	JJ	_	19	amod	_	_
21	of	of	IN	IN	_	23	mark	_	_
22	partially	partially	RB	RB	_	23	advmod	_	_
23	inhibiting	inhibit	VBG	VBG	_	20	advcl	_	_
24	the	the	DT	DT	_	26	det	_	_
25	induced	induce	VBN	VBN	_	26	amod	_	_
26	expression	expression	NN	NN	_	23	dobj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	E-selectin	e-selectin	NN	NN	_	26	nmod	_	_
29	and	and	CC	CC	_	26	cc	_	_
30	neutrophil-like	neutrophil-like	JJ	JJ	_	32	amod	_	_
31	HL60	hl60	NN	NN	_	32	compound	_	_
32	cell	cell	NN	NN	_	26	conj	_	_
33	binding	bind	VBG	VBG	_	32	amod	_	_
34	to	to	TO	TO	_	36	case	_	_
35	PMA-activated	pma-activated	JJ	JJ	_	36	amod	_	_
36	HAECs	haec	NNS	NNS	_	32	nmod	_	_
37	.	.	.	.	_	10	punct	_	_

1	Intracellular	intracellular	JJ	JJ	_	4	amod	_	_
2	adhesion	adhesion	NN	NN	_	4	compound	_	_
3	molecule-1	molecule-1	NN	NN	_	4	compound	_	_
4	induction	induction	NN	NN	_	8	nsubj	_	_
5	by	by	IN	IN	_	6	case	_	_
6	PMA	pma	NN	NN	_	4	nmod	_	_
7	was	be	VBD	VBD	_	8	aux	_	_
8	unaffected	unaffected	JJ	JJ	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	any	any	DT	DT	_	8	nmod	_	_
11	of	of	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	molecules	molecule	NNS	NNS	_	10	nmod	_	_
14	tested	test	VBN	VBN	_	13	acl	_	_
15	.	.	.	.	_	8	punct	_	_

1	Both	both	CC	CC	_	2	cc:preconj	_	_
2	PPAR-alpha	ppar-alpha	NN	NN	_	7	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	PPAR-gamma	ppar-gamma	NN	NN	_	2	conj	_	_
5	mRNAs	mrna	NNS	NNS	_	2	dep	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	detected	detect	VBN	VBN	_	0	root	_	_
8	in	in	IN	IN	_	9	case	_	_
9	HAECs	haec	NNS	NNS	_	7	nmod	_	_
10	by	by	IN	IN	_	11	case	_	_
11	using	use	VBG	VBG	_	7	advcl	_	_
12	reverse	reverse	JJ	JJ	_	15	amod	_	_
13	transcription-polymerase	transcription-polymerase	JJ	JJ	_	15	amod	_	_
14	chain	chain	NN	NN	_	15	compound	_	_
15	reaction	reaction	NN	NN	_	11	dobj	_	_
16	and	and	CC	CC	_	11	cc	_	_
17	a	a	DT	DT	_	20	det	_	_
18	ribonuclease	ribonuclease	NN	NN	_	20	compound	_	_
19	protection	protection	NN	NN	_	20	compound	_	_
20	assay	assay	NN	NN	_	11	conj	_	_
21	;	;	:	:	_	7	punct	_	_
22	however	however	RB	RB	_	25	advmod	_	_
23	,	,	,	,	_	25	punct	_	_
24	we	we	PRP	PRP	_	25	nsubj	_	_
25	have	have	VBP	VBP	_	7	parataxis	_	_
26	yet	yet	RB	RB	_	28	advmod	_	_
27	to	to	TO	TO	_	28	mark	_	_
28	determine	determine	VB	VB	_	25	xcomp	_	_
29	which	which	WDT	WDT	_	38	nsubj	_	_
30	,	,	,	,	_	32	punct	_	_
31	if	if	IN	IN	_	32	mark	_	_
32	any	any	DT	DT	_	29	dep	_	_
33	,	,	,	,	_	32	punct	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	PPARs	ppar	NNS	NNS	_	29	nmod	_	_
37	are	be	VBP	VBP	_	38	aux	_	_
38	mediating	mediate	VBG	VBG	_	28	ccomp	_	_
39	this	this	DT	DT	_	40	det	_	_
40	process	process	NN	NN	_	38	dobj	_	_
41	.	.	.	.	_	7	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	results	result	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	9	mark	_	_
5	certain	certain	JJ	JJ	_	7	amod	_	_
6	PPAR	ppar	NN	NN	_	7	compound	_	_
7	activators	activator	NNS	NNS	_	9	nsubj	_	_
8	may	may	MD	MD	_	9	aux	_	_
9	help	help	VB	VB	_	3	ccomp	_	_
10	limit	limit	VB	VB	_	9	xcomp	_	_
11	chronic	chronic	JJ	JJ	_	12	amod	_	_
12	inflammation	inflammation	NN	NN	_	10	dobj	_	_
13	mediated	mediate	VBN	VBN	_	12	acl	_	_
14	by	by	IN	IN	_	15	case	_	_
15	VCAM-1	vcam-1	NN	NN	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	monocytes	monocyte	NNS	NNS	_	15	conj	_	_
18	without	without	IN	IN	_	19	mark	_	_
19	affecting	affect	VBG	VBG	_	10	advcl	_	_
20	acute	acute	JJ	JJ	_	21	amod	_	_
21	inflammation	inflammation	NN	NN	_	19	dobj	_	_
22	mediated	mediate	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	E-selectin	e-selectin	NN	NN	_	22	nmod	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	neutrophil	neutrophil	JJ	JJ	_	24	conj	_	_
27	binding	binding	NN	NN	_	24	dep	_	_
28	.	.	.	.	_	3	punct	_	_

1	9-cis	9-cis	JJ	JJ	_	3	amod	_	_
2	retinoic	retinoic	JJ	JJ	_	3	amod	_	_
3	acid	acid	NN	NN	_	4	nsubj	_	_
4	induces	induce	VBZ	VBZ	_	0	root	_	_
5	monocyte	monocyte	NN	NN	_	8	compound	_	_
6	chemoattractant	chemoattractant	NN	NN	_	8	compound	_	_
7	protein-1	protein-1	NN	NN	_	8	compound	_	_
8	secretion	secretion	NN	NN	_	4	dobj	_	_
9	in	in	IN	IN	_	13	case	_	_
10	human	human	JJ	JJ	_	13	amod	_	_
11	monocytic	monocytic	JJ	JJ	_	13	amod	_	_
12	THP-1	thp-1	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	4	nmod	_	_
14	.	.	.	.	_	4	punct	_	_

1	Monocyte	monocyte	NN	NN	_	6	nsubjpass	_	_
2	migration	migration	NN	NN	_	1	dep	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activation	activation	NN	NN	_	2	conj	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	regulated	regulate	VBN	VBN	_	0	root	_	_
7	by	by	IN	IN	_	10	case	_	_
8	monocyte	monocyte	NN	NN	_	10	compound	_	_
9	chemoattractant	chemoattractant	NN	NN	_	10	compound	_	_
10	protein-1	protein-1	NN	NN	_	6	nmod	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	MCP-1	mcp-1	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	.	.	.	.	_	6	punct	_	_

1	Prior	prior	JJ	JJ	_	2	amod	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	have	have	VBP	VBP	_	4	aux	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	MCP-1	mcp-1	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	8	nsubjpass	_	_
7	is	be	VBZ	VBZ	_	8	auxpass	_	_
8	modulated	modulate	VBN	VBN	_	4	ccomp	_	_
9	by	by	IN	IN	_	11	case	_	_
10	a	a	DT	DT	_	11	det	_	_
11	variety	variety	NN	NN	_	8	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	ligands	ligand	NNS	NNS	_	11	nmod	_	_
14	that	that	WDT	WDT	_	15	nsubj	_	_
15	act	act	VBP	VBP	_	13	acl:relcl	_	_
16	through	through	IN	IN	_	18	case	_	_
17	extracellular	extracellular	JJ	JJ	_	18	amod	_	_
18	receptors	receptor	NNS	NNS	_	15	nmod	_	_
19	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	current	current	JJ	JJ	_	4	amod	_	_
4	study	study	NN	NN	_	7	nmod	_	_
5	,	,	,	,	_	7	punct	_	_
6	we	we	PRP	PRP	_	7	nsubj	_	_
7	show	show	VBP	VBP	_	0	root	_	_
8	9-cis	9-cis	JJ	JJ	_	10	amod	_	_
9	retinoic	retinoic	JJ	JJ	_	10	amod	_	_
10	acid	acid	NN	NN	_	37	nsubj	_	_
11	(	(	-LRB-	-LRB-	_	12	punct	_	_
12	RA	ra	NN	NN	_	10	appos	_	_
13	)	)	-RRB-	-RRB-	_	12	punct	_	_
14	,	,	,	,	_	10	punct	_	_
15	a	a	DT	DT	_	16	det	_	_
16	ligand	ligand	NN	NN	_	10	appos	_	_
17	for	for	IN	IN	_	21	case	_	_
18	the	the	DT	DT	_	21	det	_	_
19	nuclear	nuclear	JJ	JJ	_	21	amod	_	_
20	hormone	hormone	NN	NN	_	21	compound	_	_
21	receptor	receptor	NN	NN	_	16	nmod	_	_
22	retinoid	retinoid	NN	NN	_	24	compound	_	_
23	X	x	NN	NN	_	24	compound	_	_
24	receptor	receptor	NN	NN	_	21	dep	_	_
25	(	(	-LRB-	-LRB-	_	26	punct	_	_
26	RXR	rxr	NN	NN	_	24	appos	_	_
27	)	)	-RRB-	-RRB-	_	26	punct	_	_
28	and	and	CC	CC	_	24	cc	_	_
29	retinoic	retinoic	JJ	JJ	_	31	amod	_	_
30	acid	acid	NN	NN	_	31	compound	_	_
31	receptor	receptor	NN	NN	_	24	conj	_	_
32	(	(	-LRB-	-LRB-	_	33	punct	_	_
33	RAR	rar	NN	NN	_	31	appos	_	_
34	)	)	-RRB-	-RRB-	_	33	punct	_	_
35	,	,	,	,	_	10	punct	_	_
36	markedly	markedly	RB	RB	_	37	advmod	_	_
37	induces	induce	VBZ	VBZ	_	7	ccomp	_	_
38	the	the	DT	DT	_	39	det	_	_
39	expression	expression	NN	NN	_	37	dobj	_	_
40	of	of	IN	IN	_	41	case	_	_
41	MCP-1	mcp-1	NN	NN	_	39	nmod	_	_
42	.	.	.	.	_	7	punct	_	_

1	In	in	IN	IN	_	6	case	_	_
2	human	human	JJ	JJ	_	6	amod	_	_
3	THP-1	thp-1	NN	NN	_	6	compound	_	_
4	monocytic	monocytic	JJ	JJ	_	6	amod	_	_
5	leukemia	leukemia	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	20	nmod	_	_
7	cultured	culture	VBN	VBN	_	6	acl	_	_
8	with	with	IN	IN	_	9	case	_	_
9	RA	ra	NN	NN	_	7	nmod	_	_
10	(	(	-LRB-	-LRB-	_	14	punct	_	_
11	0.05	0.05	CD	CD	_	13	compound	_	_
12	to	to	TO	TO	_	13	dep	_	_
13	500	500	CD	CD	_	14	nummod	_	_
14	nmol/L	nmol/l	NN	NN	_	9	appos	_	_
15	)	)	-RRB-	-RRB-	_	14	punct	_	_
16	,	,	,	,	_	20	punct	_	_
17	MCP-1	mcp-1	NN	NN	_	18	compound	_	_
18	expression	expression	NN	NN	_	20	nsubjpass	_	_
19	was	be	VBD	VBD	_	20	auxpass	_	_
20	induced	induce	VBN	VBN	_	0	root	_	_
21	rapidly	rapidly	RB	RB	_	25	advmod	_	_
22	,	,	,	,	_	25	punct	_	_
23	significantly	significantly	RB	RB	_	25	advmod	_	_
24	,	,	,	,	_	25	punct	_	_
25	and	and	CC	CC	_	20	advmod	_	_
26	dose-dependently	dose-dependently	RB	RB	_	25	advmod	_	_
27	by	by	IN	IN	_	29	case	_	_
28	as	as	RB	RB	_	29	advmod	_	_
29	much	much	JJ	JJ	_	20	nmod	_	_
30	as	as	IN	IN	_	29	advmod	_	_
31	165-fold	165-fold	RB	RB	_	29	advmod	_	_
32	.	.	.	.	_	20	punct	_	_

1	MCP-1	mcp-1	NN	NN	_	3	compound	_	_
2	RNA	rna	NN	NN	_	3	compound	_	_
3	level	level	NN	NN	_	6	nsubjpass	_	_
4	was	be	VBD	VBD	_	6	auxpass	_	_
5	also	also	RB	RB	_	6	advmod	_	_
6	increased	increase	VBN	VBN	_	0	root	_	_
7	in	in	IN	IN	_	9	case	_	_
8	RA-treated	ra-treated	JJ	JJ	_	9	amod	_	_
9	cells	cell	NNS	NNS	_	6	nmod	_	_
10	.	.	.	.	_	6	punct	_	_

1	Expression	expression	NN	NN	_	14	nsubjpass	_	_
2	of	of	IN	IN	_	3	case	_	_
3	PPARgamma	ppargamma	NN	NN	_	1	nmod	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	heterodimer	heterodimer	NN	NN	_	7	compound	_	_
7	partner	partner	NN	NN	_	3	appos	_	_
8	of	of	IN	IN	_	9	case	_	_
9	RXR	rxr	NN	NN	_	7	nmod	_	_
10	,	,	,	,	_	3	punct	_	_
11	is	be	VBZ	VBZ	_	14	auxpass	_	_
12	also	also	RB	RB	_	14	advmod	_	_
13	markedly	markedly	RB	RB	_	14	advmod	_	_
14	induced	induce	VBN	VBN	_	0	root	_	_
15	by	by	IN	IN	_	16	case	_	_
16	RA	ra	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	19	case	_	_
18	THP-1	thp-1	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	14	nmod	_	_
20	.	.	.	.	_	14	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	BRL49653	brl49653	NN	NN	_	9	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	a	a	DT	DT	_	7	det	_	_
6	PPARgamma	ppargamma	NN	NN	_	7	compound	_	_
7	ligand	ligand	NN	NN	_	3	appos	_	_
8	,	,	,	,	_	3	punct	_	_
9	failed	fail	VBD	VBD	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	induce	induce	VB	VB	_	9	ccomp	_	_
12	MCP-1	mcp-1	NN	NN	_	13	compound	_	_
13	secretion	secretion	NN	NN	_	11	dobj	_	_
14	either	either	CC	CC	_	11	advmod	_	_
15	alone	alone	RB	RB	_	11	advmod	_	_
16	or	or	CC	CC	_	11	cc	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	modify	modify	VB	VB	_	11	conj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	expression	expression	NN	NN	_	21	compound	_	_
21	level	level	NN	NN	_	18	dobj	_	_
22	induced	induce	VBN	VBN	_	21	acl	_	_
23	by	by	IN	IN	_	24	case	_	_
24	RA	ra	NN	NN	_	22	nmod	_	_
25	.	.	.	.	_	9	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	contrast	contrast	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	BRL49653	brl49653	NN	NN	_	6	nsubj	_	_
5	significantly	significantly	RB	RB	_	6	advmod	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	MCP-1	mcp-1	NN	NN	_	6	dobj	_	_
8	(	(	-LRB-	-LRB-	_	10	punct	_	_
9	biotinylated	biotinylate	VBN	VBN	_	10	amod	_	_
10	MCP-1	mcp-1	NN	NN	_	7	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	binding	bind	VBG	VBG	_	7	amod	_	_
13	to	to	TO	TO	_	15	case	_	_
14	THP-1	thp-1	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	7	nmod	_	_
16	,	,	,	,	_	6	punct	_	_
17	whereas	whereas	IN	IN	_	6	dep	_	_
18	RA	ra	NN	NN	_	19	nsubj	_	_
19	had	have	VBD	VBD	_	6	parataxis	_	_
20	no	no	DT	DT	_	21	neg	_	_
21	effect	effect	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	6	punct	_	_

1	Other	other	JJ	JJ	_	9	amod	_	_
2	peroxisome	peroxisome	JJ	JJ	_	9	amod	_	_
3	proliferator	proliferator	NN	NN	_	9	compound	_	_
4	activated	activated	JJ	JJ	_	9	amod	_	_
5	receptor	receptor	NN	NN	_	9	compound	_	_
6	(	(	-LRB-	-LRB-	_	9	punct	_	_
7	PPAR	ppar	NN	NN	_	9	compound	_	_
8	)	)	-RRB-	-RRB-	_	9	punct	_	_
9	ligands	ligand	NNS	NNS	_	33	nsubj	_	_
10	,	,	,	,	_	9	punct	_	_
11	15d-PGJ	15d-pgj	NN	NN	_	9	appos	_	_
12	(	(	-LRB-	-LRB-	_	11	punct	_	_
13	2	2	CD	CD	_	11	nummod	_	_
14	)	)	-RRB-	-RRB-	_	11	punct	_	_
15	and	and	CC	CC	_	11	cc	_	_
16	troglitazone	troglitazone	NN	NN	_	11	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	PPARgamma	ppargamma	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	,	,	,	,	_	16	punct	_	_
21	Wy14	wy14	NN	NN	_	16	conj	_	_
22	,	,	,	,	_	21	punct	_	_
23	643	643	CD	CD	_	21	nummod	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	PPARalpha	pparalpha	NN	NN	_	21	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	,	,	,	,	_	16	punct	_	_
28	and	and	CC	CC	_	16	cc	_	_
29	PD195599	pd195599	NN	NN	_	16	conj	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	PPARbeta	pparbeta	NN	NN	_	29	appos	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	inhibited	inhibit	VBD	VBD	_	0	root	_	_
34	the	the	DT	DT	_	35	det	_	_
35	induction	induction	NN	NN	_	33	dobj	_	_
36	of	of	IN	IN	_	37	case	_	_
37	MCP-1	mcp-1	NN	NN	_	35	nmod	_	_
38	by	by	IN	IN	_	39	case	_	_
39	RA	ra	NN	NN	_	35	nmod	_	_
40	.	.	.	.	_	33	punct	_	_

1	RA	ra	NN	NN	_	3	nmod:poss	_	_
2	's	's	POS	POS	_	3	case	_	_
3	effect	effect	NN	NN	_	12	nsubj	_	_
4	on	on	IN	IN	_	6	case	_	_
5	MCP-1	mcp-1	NN	NN	_	6	compound	_	_
6	expression	expression	NN	NN	_	3	nmod	_	_
7	in	in	IN	IN	_	10	case	_	_
8	human	human	JJ	JJ	_	10	amod	_	_
9	elutriated	elutriate	VBN	VBN	_	10	amod	_	_
10	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
11	were	be	VBD	VBD	_	12	cop	_	_
12	similar	similar	JJ	JJ	_	0	root	_	_
13	to	to	TO	TO	_	14	case	_	_
14	that	that	DT	DT	_	12	nmod	_	_
15	observed	observe	VBN	VBN	_	14	acl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	THP-1	thp-1	NN	NN	_	19	compound	_	_
19	cells	cell	NNS	NNS	_	15	nmod	_	_
20	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	3	nsubj	_	_
3	identify	identify	VBP	VBP	_	0	root	_	_
4	RA	ra	NN	NN	_	3	dobj	_	_
5	as	as	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
8	signal	signal	NN	NN	_	3	nmod	_	_
9	for	for	IN	IN	_	11	case	_	_
10	MCP-1	mcp-1	NN	NN	_	11	compound	_	_
11	induction	induction	NN	NN	_	8	nmod	_	_
12	in	in	IN	IN	_	16	case	_	_
13	undifferentiated	undifferentiated	JJ	JJ	_	16	amod	_	_
14	human	human	JJ	JJ	_	16	amod	_	_
15	monocytic	monocytic	JJ	JJ	_	16	amod	_	_
16	cells	cell	NNS	NNS	_	8	nmod	_	_
17	.	.	.	.	_	3	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	studies	study	NNS	NNS	_	4	nsubj	_	_
3	also	also	RB	RB	_	4	advmod	_	_
4	suggest	suggest	VBP	VBP	_	0	root	_	_
5	monocyte	monocyte	NN	NN	_	7	compound	_	_
6	MCP-1	mcp-1	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	12	nsubj	_	_
8	induced	induce	VBN	VBN	_	7	acl	_	_
9	through	through	IN	IN	_	10	case	_	_
10	RA	ra	NN	NN	_	8	nmod	_	_
11	may	may	MD	MD	_	12	aux	_	_
12	modulate	modulate	VB	VB	_	4	ccomp	_	_
13	cell	cell	NN	NN	_	14	compound	_	_
14	migration	migration	NN	NN	_	12	dobj	_	_
15	.	.	.	.	_	4	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	2	compound	_	_
2	maturation	maturation	NN	NN	_	0	root	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	the	the	DT	DT	_	5	det	_	_
5	role	role	NN	NN	_	2	conj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	retinoic	retinoic	JJ	JJ	_	8	amod	_	_
8	acid	acid	NN	NN	_	5	nmod	_	_
9	.	.	.	.	_	2	punct	_	_

1	Neutrophil	neutrophil	NN	NN	_	2	compound	_	_
2	maturation	maturation	NN	NN	_	3	nsubj	_	_
3	occurs	occur	VBZ	VBZ	_	0	root	_	_
4	in	in	IN	IN	_	8	case	_	_
5	well	well	RB	RB	_	6	advmod	_	_
6	defined	define	VBN	VBN	_	8	amod	_	_
7	morphological	morphological	JJ	JJ	_	8	amod	_	_
8	stages	stage	NNS	NNS	_	3	nmod	_	_
9	that	that	WDT	WDT	_	10	nsubj	_	_
10	correlate	correlate	VBP	VBP	_	8	acl:relcl	_	_
11	with	with	IN	IN	_	13	case	_	_
12	the	the	DT	DT	_	13	det	_	_
13	acquisition	acquisition	NN	NN	_	10	nmod	_	_
14	of	of	IN	IN	_	16	case	_	_
15	molecular	molecular	JJ	JJ	_	16	amod	_	_
16	markers	marker	NNS	NNS	_	13	nmod	_	_
17	associated	associate	VBN	VBN	_	16	amod	_	_
18	with	with	IN	IN	_	20	case	_	_
19	neutrophil	neutrophil	NN	NN	_	20	compound	_	_
20	function	function	NN	NN	_	17	nmod	_	_
21	.	.	.	.	_	3	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	variety	variety	NN	NN	_	6	nsubjpass	_	_
3	of	of	IN	IN	_	4	case	_	_
4	factors	factor	NNS	NNS	_	2	nmod	_	_
5	are	be	VBP	VBP	_	6	auxpass	_	_
6	known	know	VBN	VBN	_	0	root	_	_
7	to	to	TO	TO	_	8	mark	_	_
8	play	play	VB	VB	_	6	xcomp	_	_
9	a	a	DT	DT	_	10	det	_	_
10	role	role	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	terminal	terminal	JJ	JJ	_	14	amod	_	_
13	neutrophil	neutrophil	NN	NN	_	14	compound	_	_
14	maturation	maturation	NN	NN	_	8	nmod	_	_
15	,	,	,	,	_	14	punct	_	_
16	including	include	VBG	VBG	_	20	case	_	_
17	the	the	DT	DT	_	20	det	_	_
18	vitamin	vitamin	NN	NN	_	20	compound	_	_
19	A	a	NN	NN	_	20	compound	_	_
20	derivative	derivative	NN	NN	_	14	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	retinoic	retinoic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	20	appos	_	_
24	.	.	.	.	_	6	punct	_	_

1	Retinoic	retinoic	JJ	JJ	_	2	amod	_	_
2	acid	acid	NN	NN	_	5	nsubj	_	_
3	can	can	MD	MD	_	5	aux	_	_
4	directly	directly	RB	RB	_	5	advmod	_	_
5	modulate	modulate	VB	VB	_	0	root	_	_
6	gene	gene	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	5	dobj	_	_
8	via	via	IN	IN	_	9	case	_	_
9	binding	bind	VBG	VBG	_	5	nmod	_	_
10	to	to	TO	TO	_	13	case	_	_
11	its	its	PRP$	PRP$	_	13	nmod:poss	_	_
12	nuclear	nuclear	JJ	JJ	_	13	amod	_	_
13	receptors	receptor	NNS	NNS	_	9	nmod	_	_
14	,	,	,	,	_	13	punct	_	_
15	which	which	WDT	WDT	_	21	nsubj	_	_
16	can	can	MD	MD	_	21	aux	_	_
17	,	,	,	,	_	21	punct	_	_
18	in	in	IN	IN	_	19	case	_	_
19	turn	turn	NN	NN	_	21	nmod	_	_
20	,	,	,	,	_	21	punct	_	_
21	activate	activate	VBP	VBP	_	13	acl:relcl	_	_
22	transcription	transcription	NN	NN	_	21	dobj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	target	target	NN	NN	_	25	compound	_	_
25	genes	gene	NNS	NNS	_	22	nmod	_	_
26	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	role	role	NN	NN	_	11	nsubjpass	_	_
3	for	for	IN	IN	_	5	case	_	_
4	retinoic	retinoic	JJ	JJ	_	5	amod	_	_
5	acid	acid	NN	NN	_	2	nmod	_	_
6	during	during	IN	IN	_	8	case	_	_
7	neutrophil	neutrophil	NN	NN	_	8	compound	_	_
8	maturation	maturation	NN	NN	_	2	nmod	_	_
9	has	have	VBZ	VBZ	_	11	aux	_	_
10	been	be	VBN	VBN	_	11	auxpass	_	_
11	suggested	suggest	VBN	VBN	_	0	root	_	_
12	from	from	IN	IN	_	14	case	_	_
13	a	a	DT	DT	_	14	det	_	_
14	variety	variety	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	16	case	_	_
16	sources	source	NNS	NNS	_	14	nmod	_	_
17	.	.	.	.	_	11	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	present	present	VBP	VBP	_	0	root	_	_
4	a	a	DT	DT	_	5	det	_	_
5	review	review	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	mechanism	mechanism	NN	NN	_	5	nmod	_	_
9	of	of	IN	IN	_	13	case	_	_
10	retinoic	retinoic	JJ	JJ	_	13	amod	_	_
11	acid	acid	NN	NN	_	13	compound	_	_
12	receptor	receptor	NN	NN	_	13	compound	_	_
13	action	action	NN	NN	_	8	nmod	_	_
14	and	and	CC	CC	_	5	cc	_	_
15	the	the	DT	DT	_	17	det	_	_
16	major	major	JJ	JJ	_	17	amod	_	_
17	evidence	evidence	NN	NN	_	5	conj	_	_
18	showing	show	VBG	VBG	_	17	acl	_	_
19	that	that	IN	IN	_	24	mark	_	_
20	normal	normal	JJ	JJ	_	22	amod	_	_
21	retinoid	retinoid	NN	NN	_	22	compound	_	_
22	signaling	signaling	NN	NN	_	24	nsubjpass	_	_
23	is	be	VBZ	VBZ	_	24	auxpass	_	_
24	required	require	VBN	VBN	_	18	ccomp	_	_
25	for	for	IN	IN	_	27	case	_	_
26	neutrophil	neutrophil	NN	NN	_	27	compound	_	_
27	maturation	maturation	NN	NN	_	24	nmod	_	_
28	.	.	.	.	_	3	punct	_	_

1	Induction	induction	NN	NN	_	0	root	_	_
2	of	of	IN	IN	_	7	case	_	_
3	Bcl-x	bcl-x	NN	NN	_	7	compound	_	_
4	(	(	-LRB-	-LRB-	_	7	punct	_	_
5	L	l	NN	NN	_	7	compound	_	_
6	)	)	-RRB-	-RRB-	_	7	punct	_	_
7	expression	expression	NN	NN	_	1	nmod	_	_
8	by	by	IN	IN	_	15	case	_	_
9	human	human	JJ	JJ	_	15	amod	_	_
10	T-cell	t-cell	NN	NN	_	15	compound	_	_
11	leukemia	leukemia	NN	NN	_	15	compound	_	_
12	virus	virus	NN	NN	_	15	compound	_	_
13	type	type	NN	NN	_	15	compound	_	_
14	1	1	CD	CD	_	15	nummod	_	_
15	Tax	tax	NN	NN	_	1	nmod	_	_
16	through	through	IN	IN	_	17	case	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	1	nmod	_	_
18	in	in	IN	IN	_	21	case	_	_
19	apoptosis-resistant	apoptosis-resistant	JJ	JJ	_	21	amod	_	_
20	T-cell	t-cell	NN	NN	_	21	compound	_	_
21	transfectants	transfectant	NNS	NNS	_	1	nmod	_	_
22	with	with	IN	IN	_	23	case	_	_
23	Tax	tax	NN	NN	_	21	nmod	_	_
24	.	.	.	.	_	1	punct	_	_

1	Human	human	JJ	JJ	_	5	amod	_	_
2	T-cell	t-cell	NN	NN	_	5	compound	_	_
3	leukemia	leukemia	NN	NN	_	5	compound	_	_
4	virus	virus	NN	NN	_	5	compound	_	_
5	type	type	NN	NN	_	10	compound	_	_
6	1	1	CD	CD	_	5	nummod	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HTLV-1	htlv-1	NN	NN	_	5	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	Tax	tax	NN	NN	_	12	nsubjpass	_	_
11	is	be	VBZ	VBZ	_	12	auxpass	_	_
12	thought	think	VBN	VBN	_	0	root	_	_
13	to	to	TO	TO	_	14	mark	_	_
14	play	play	VB	VB	_	12	xcomp	_	_
15	a	a	DT	DT	_	17	det	_	_
16	pivotal	pivotal	JJ	JJ	_	17	amod	_	_
17	role	role	NN	NN	_	14	dobj	_	_
18	in	in	IN	IN	_	19	case	_	_
19	immortalization	immortalization	NN	NN	_	14	nmod	_	_
20	of	of	IN	IN	_	22	case	_	_
21	T	t	NN	NN	_	22	compound	_	_
22	cells	cell	NNS	NNS	_	19	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	shown	show	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	the	the	DT	DT	_	7	det	_	_
7	expression	expression	NN	NN	_	10	nsubj	_	_
8	of	of	IN	IN	_	9	case	_	_
9	Tax	tax	NN	NN	_	7	nmod	_	_
10	protected	protect	VBD	VBD	_	4	ccomp	_	_
11	the	the	DT	DT	_	15	det	_	_
12	mouse	mouse	NN	NN	_	15	compound	_	_
13	T-cell	t-cell	NN	NN	_	15	compound	_	_
14	line	line	NN	NN	_	15	compound	_	_
15	CTLL-2	ctll-2	NN	NN	_	10	dobj	_	_
16	against	against	IN	IN	_	17	case	_	_
17	apoptosis	apoptosis	NN	NN	_	10	nmod	_	_
18	induced	induce	VBN	VBN	_	17	acl	_	_
19	by	by	IN	IN	_	24	case	_	_
20	interleukin-2	interleukin-2	NN	NN	_	24	compound	_	_
21	(	(	-LRB-	-LRB-	_	24	punct	_	_
22	IL-2	il-2	NN	NN	_	24	compound	_	_
23	)	)	-RRB-	-RRB-	_	24	punct	_	_
24	deprivation	deprivation	NN	NN	_	18	nmod	_	_
25	and	and	CC	CC	_	10	cc	_	_
26	converted	convert	VBD	VBD	_	10	conj	_	_
27	its	its	PRP$	PRP$	_	28	nmod:poss	_	_
28	growth	growth	NN	NN	_	26	dobj	_	_
29	from	from	IN	IN	_	32	mark	_	_
30	being	be	VBG	VBG	_	32	cop	_	_
31	IL-2	il-2	NN	NN	_	32	nmod:npmod	_	_
32	dependent	dependent	JJ	JJ	_	26	dep	_	_
33	to	to	TO	TO	_	36	mark	_	_
34	being	be	VBG	VBG	_	36	cop	_	_
35	IL-2	il-2	NN	NN	_	36	nmod:npmod	_	_
36	independent	independent	JJ	JJ	_	32	nmod	_	_
37	.	.	.	.	_	4	punct	_	_

1	In	in	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	study	study	NN	NN	_	6	nmod	_	_
4	,	,	,	,	_	6	punct	_	_
5	we	we	PRP	PRP	_	6	nsubj	_	_
6	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	25	mark	_	_
8	constitutive	constitutive	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	25	nsubjpass	_	_
10	of	of	IN	IN	_	11	case	_	_
11	bcl-xl	bcl-xl	NN	NN	_	9	nmod	_	_
12	but	but	CC	CC	_	11	cc	_	_
13	not	not	RB	RB	_	14	neg	_	_
14	bcl-2	bcl-2	NN	NN	_	11	conj	_	_
15	,	,	,	,	_	14	punct	_	_
16	bcl-xs	bcl-xs	NN	NN	_	14	conj	_	_
17	,	,	,	,	_	14	punct	_	_
18	bak	bak	NN	NN	_	14	conj	_	_
19	,	,	,	,	_	14	punct	_	_
20	bad	bad	NN	NN	_	14	conj	_	_
21	,	,	,	,	_	14	punct	_	_
22	or	or	CC	CC	_	14	cc	_	_
23	bax	bax	NN	NN	_	14	conj	_	_
24	was	be	VBD	VBD	_	25	auxpass	_	_
25	associated	associate	VBN	VBN	_	6	ccomp	_	_
26	with	with	IN	IN	_	28	case	_	_
27	apoptosis	apoptosis	JJ	JJ	_	28	amod	_	_
28	resistance	resistance	NN	NN	_	25	nmod	_	_
29	after	after	IN	IN	_	31	case	_	_
30	IL-2	il-2	NN	NN	_	31	compound	_	_
31	deprivation	deprivation	NN	NN	_	25	nmod	_	_
32	in	in	IN	IN	_	34	case	_	_
33	CTLL-2	ctll-2	NN	NN	_	34	compound	_	_
34	cells	cell	NNS	NNS	_	31	nmod	_	_
35	that	that	WDT	WDT	_	36	nsubj	_	_
36	expressed	express	VBD	VBD	_	34	acl:relcl	_	_
37	Tax	tax	NN	NN	_	36	dobj	_	_
38	.	.	.	.	_	6	punct	_	_

1	Transient-transfection	transient-transfection	JJ	JJ	_	2	amod	_	_
2	assays	assay	NNS	NNS	_	3	nsubj	_	_
3	showed	show	VBD	VBD	_	0	root	_	_
4	that	that	IN	IN	_	8	mark	_	_
5	bcl-x	bcl-x	NN	NN	_	6	compound	_	_
6	promoter	promoter	NN	NN	_	8	nsubjpass	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	transactivated	transactivate	VBN	VBN	_	3	ccomp	_	_
9	by	by	IN	IN	_	11	case	_	_
10	wild-type	wild-type	JJ	JJ	_	11	amod	_	_
11	Tax	tax	NN	NN	_	8	nmod	_	_
12	.	.	.	.	_	3	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	effects	effect	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	10	case	_	_
6	mutant	mutant	JJ	JJ	_	10	amod	_	_
7	Tax	tax	NN	NN	_	10	compound	_	_
8	retaining	retain	VBG	VBG	_	10	amod	_	_
9	transactivating	transactivating	NN	NN	_	10	compound	_	_
10	ability	ability	NN	NN	_	4	nmod	_	_
11	through	through	IN	IN	_	12	case	_	_
12	NF-kappaB	nf-kappab	NN	NN	_	4	nmod	_	_
13	.	.	.	.	_	4	punct	_	_

1	Deletion	deletion	NN	NN	_	16	nsubj	_	_
2	or	or	CC	CC	_	1	cc	_	_
3	substitution	substitution	NN	NN	_	1	conj	_	_
4	of	of	IN	IN	_	9	case	_	_
5	a	a	DT	DT	_	9	det	_	_
6	putative	putative	JJ	JJ	_	9	amod	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	9	compound	_	_
8	binding	binding	NN	NN	_	9	compound	_	_
9	site	site	NN	NN	_	1	nmod	_	_
10	identified	identify	VBN	VBN	_	9	acl	_	_
11	in	in	IN	IN	_	14	case	_	_
12	the	the	DT	DT	_	14	det	_	_
13	bcl-x	bcl-x	NN	NN	_	14	compound	_	_
14	promoter	promoter	NN	NN	_	10	nmod	_	_
15	significantly	significantly	RB	RB	_	16	advmod	_	_
16	decreased	decrease	VBD	VBD	_	0	root	_	_
17	Tax-induced	tax-induced	JJ	JJ	_	18	amod	_	_
18	transactivation	transactivation	NN	NN	_	16	dobj	_	_
19	.	.	.	.	_	16	punct	_	_

1	This	this	DT	DT	_	3	det	_	_
2	NF-kappaB-like	nf-kappab-like	JJ	JJ	_	3	amod	_	_
3	element	element	NN	NN	_	5	nsubj	_	_
4	was	be	VBD	VBD	_	5	cop	_	_
5	able	able	JJ	JJ	_	0	root	_	_
6	to	to	TO	TO	_	7	mark	_	_
7	form	form	VB	VB	_	5	xcomp	_	_
8	a	a	DT	DT	_	9	det	_	_
9	complex	complex	NN	NN	_	7	dobj	_	_
10	with	with	IN	IN	_	13	case	_	_
11	NF-kappaB	nf-kappab	NN	NN	_	13	compound	_	_
12	family	family	NN	NN	_	13	compound	_	_
13	proteins	protein	NNS	NNS	_	9	nmod	_	_
14	in	in	FW	FW	_	15	compound	_	_
15	vitro	vitro	FW	FW	_	7	advmod	_	_
16	.	.	.	.	_	5	punct	_	_

1	Furthermore	furthermore	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	Tax-induced	tax-induced	JJ	JJ	_	4	amod	_	_
4	transactivation	transactivation	NN	NN	_	11	nsubjpass	_	_
5	of	of	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	bcl-x	bcl-x	NN	NN	_	8	compound	_	_
8	promoter	promoter	NN	NN	_	4	nmod	_	_
9	was	be	VBD	VBD	_	11	auxpass	_	_
10	also	also	RB	RB	_	11	advmod	_	_
11	diminished	diminish	VBN	VBN	_	0	root	_	_
12	by	by	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	mutant	mutant	JJ	JJ	_	15	amod	_	_
15	IkappaBalpha	ikappabalpha	NN	NN	_	11	nmod	_	_
16	,	,	,	,	_	15	punct	_	_
17	which	which	WDT	WDT	_	19	nsubj	_	_
18	specifically	specifically	RB	RB	_	19	advmod	_	_
19	inhibits	inhibit	VBZ	VBZ	_	15	acl:relcl	_	_
20	NF-kappaB	nf-kappab	NN	NN	_	21	compound	_	_
21	activity	activity	NN	NN	_	19	dobj	_	_
22	.	.	.	.	_	11	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	constitutive	constitutive	JJ	JJ	_	6	amod	_	_
6	expression	expression	NN	NN	_	19	nsubj	_	_
7	of	of	IN	IN	_	10	case	_	_
8	Bcl-x	bcl-x	NN	NN	_	10	compound	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	L	l	NN	NN	_	6	nmod	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	induced	induce	VBN	VBN	_	6	acl	_	_
13	by	by	IN	IN	_	14	case	_	_
14	Tax	tax	NN	NN	_	12	nmod	_	_
15	through	through	IN	IN	_	18	case	_	_
16	the	the	DT	DT	_	18	det	_	_
17	NF-kappaB	nf-kappab	NN	NN	_	18	compound	_	_
18	pathway	pathway	NN	NN	_	12	nmod	_	_
19	contributes	contribute	VBZ	VBZ	_	3	ccomp	_	_
20	to	to	TO	TO	_	22	dep	_	_
21	the	the	DT	DT	_	22	det	_	_
22	inhibition	inhibition	NN	NN	_	19	dobj	_	_
23	of	of	IN	IN	_	24	case	_	_
24	apoptosis	apoptosis	NN	NN	_	22	nmod	_	_
25	in	in	IN	IN	_	27	case	_	_
26	CTLL-2	ctll-2	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	nmod	_	_
28	after	after	IN	IN	_	30	case	_	_
29	IL-2	il-2	NN	NN	_	30	compound	_	_
30	deprivation	deprivation	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	3	punct	_	_

1	Target	target	NN	NN	_	2	compound	_	_
2	structures	structure	NNS	NNS	_	0	root	_	_
3	of	of	IN	IN	_	6	case	_	_
4	the	the	DT	DT	_	6	det	_	_
5	CD8(+)-T-cell	cd8(+)-t-cell	NN	NN	_	6	compound	_	_
6	response	response	NN	NN	_	2	nmod	_	_
7	to	to	TO	TO	_	9	case	_	_
8	human	human	JJ	JJ	_	9	amod	_	_
9	cytomegalovirus	cytomegalovirus	NN	NN	_	6	nmod	_	_
10	:	:	:	:	_	2	punct	_	_
11	the	the	DT	DT	_	15	det	_	_
12	72-kilodalton	72-kilodalton	JJ	JJ	_	15	amod	_	_
13	major	major	JJ	JJ	_	15	amod	_	_
14	immediate-early	immediate-early	JJ	JJ	_	15	amod	_	_
15	protein	protein	NN	NN	_	2	dep	_	_
16	revisited	revisit	VBN	VBN	_	15	acl	_	_
17	.	.	.	.	_	2	punct	_	_

1	Cell-mediated	cell-mediated	JJ	JJ	_	2	amod	_	_
2	immunity	immunity	NN	NN	_	3	nsubj	_	_
3	plays	play	VBZ	VBZ	_	0	root	_	_
4	an	a	DT	DT	_	6	det	_	_
5	essential	essential	JJ	JJ	_	6	amod	_	_
6	role	role	NN	NN	_	3	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	control	control	NN	NN	_	3	nmod	_	_
10	of	of	IN	IN	_	11	case	_	_
11	infection	infection	NN	NN	_	9	nmod	_	_
12	with	with	IN	IN	_	15	case	_	_
13	the	the	DT	DT	_	15	det	_	_
14	human	human	JJ	JJ	_	15	amod	_	_
15	cytomegalovirus	cytomegalovirus	NN	NN	_	11	nmod	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	HCMV	hcmv	NN	NN	_	15	appos	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	.	.	.	.	_	3	punct	_	_

1	However	however	RB	RB	_	9	advmod	_	_
2	,	,	,	,	_	9	punct	_	_
3	only	only	RB	RB	_	7	advmod	_	_
4	a	a	DT	DT	_	7	det	_	_
5	few	few	JJ	JJ	_	7	amod	_	_
6	CD8(+)-T-cell	cd8(+)-t-cell	NN	NN	_	7	compound	_	_
7	epitopes	epitope	NNS	NNS	_	9	nsubjpass	_	_
8	are	be	VBP	VBP	_	9	auxpass	_	_
9	known	know	VBN	VBN	_	0	root	_	_
10	,	,	,	,	_	9	punct	_	_
11	with	with	IN	IN	_	15	mark	_	_
12	the	the	DT	DT	_	13	det	_	_
13	majority	majority	NN	NN	_	15	nsubjpass	_	_
14	being	be	VBG	VBG	_	15	auxpass	_	_
15	contained	contain	VBN	VBN	_	9	advcl	_	_
16	in	in	IN	IN	_	19	case	_	_
17	the	the	DT	DT	_	19	det	_	_
18	pp65	pp65	NN	NN	_	19	compound	_	_
19	phosphoprotein	phosphoprotein	NN	NN	_	15	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	which	which	WDT	WDT	_	24	nsubj	_	_
22	is	be	VBZ	VBZ	_	24	dep	_	_
23	believed	believe	VBN	VBN	_	24	dep	_	_
24	to	to	TO	TO	_	19	acl:relcl	_	_
25	dominate	dominate	VB	VB	_	24	dep	_	_
26	the	the	DT	DT	_	24	dep	_	_
27	CD8(+)-T-cell	cd8(+)-t-cell	NN	NN	_	24	dep	_	_
28	response	response	NN	NN	_	24	dep	_	_
29	to	to	TO	TO	_	24	dep	_	_
30	HCMV	hcmv	NN	NN	_	24	dep	_	_
31	.	.	.	.	_	9	punct	_	_

1	Here	here	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	we	we	PRP	PRP	_	5	nsubj	_	_
4	have	have	VBP	VBP	_	5	aux	_	_
5	readdressed	readdress	VBN	VBN	_	0	root	_	_
6	the	the	DT	DT	_	7	det	_	_
7	issue	issue	NN	NN	_	5	dobj	_	_
8	of	of	IN	IN	_	11	case	_	_
9	CD8(+)	cd8(+)	JJ	JJ	_	11	amod	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	7	nmod	_	_
12	specific	specific	JJ	JJ	_	11	amod	_	_
13	for	for	IN	IN	_	18	case	_	_
14	the	the	DT	DT	_	18	det	_	_
15	72-kDa	72-kda	JJ	JJ	_	18	amod	_	_
16	major	major	JJ	JJ	_	18	amod	_	_
17	immediate-early	immediate-early	JJ	JJ	_	18	amod	_	_
18	protein	protein	NN	NN	_	12	nmod	_	_
19	(	(	-LRB-	-LRB-	_	20	punct	_	_
20	IE-1	ie-1	NN	NN	_	18	appos	_	_
21	)	)	-RRB-	-RRB-	_	20	punct	_	_
22	,	,	,	,	_	18	punct	_	_
23	which	which	WDT	WDT	_	25	nsubj	_	_
24	is	be	VBZ	VBZ	_	25	cop	_	_
25	nonstructural	nonstructural	JJ	JJ	_	18	acl:relcl	_	_
26	but	but	CC	CC	_	25	cc	_	_
27	is	be	VBZ	VBZ	_	28	auxpass	_	_
28	found	find	VBN	VBN	_	25	conj	_	_
29	very	very	RB	RB	_	30	advmod	_	_
30	early	early	RB	RB	_	31	advmod	_	_
31	and	and	CC	CC	_	28	advmod	_	_
32	throughout	throughout	IN	IN	_	35	case	_	_
33	the	the	DT	DT	_	35	det	_	_
34	replicative	replicative	JJ	JJ	_	35	amod	_	_
35	cycle	cycle	NN	NN	_	31	conj	_	_
36	.	.	.	.	_	5	punct	_	_

1	Using	use	VBG	VBG	_	9	advcl	_	_
2	a	a	DT	DT	_	5	det	_	_
3	novel	novel	JJ	JJ	_	5	amod	_	_
4	flow-cytometric	flow-cytometric	JJ	JJ	_	5	amod	_	_
5	assay	assay	NN	NN	_	1	dobj	_	_
6	,	,	,	,	_	9	punct	_	_
7	we	we	PRP	PRP	_	9	nsubj	_	_
8	were	be	VBD	VBD	_	9	cop	_	_
9	able	able	JJ	JJ	_	0	root	_	_
10	to	to	TO	TO	_	11	mark	_	_
11	identify	identify	VB	VB	_	9	dep	_	_
12	CD8(+)-T-cell	cd8(+)-t-cell	NN	NN	_	13	compound	_	_
13	epitopes	epitope	NNS	NNS	_	11	dobj	_	_
14	(	(	-LRB-	-LRB-	_	18	punct	_	_
15	by	by	IN	IN	_	18	case	_	_
16	IE-1	ie-1	NN	NN	_	18	compound	_	_
17	peptide-specific	peptide-specific	JJ	JJ	_	18	amod	_	_
18	induction	induction	NN	NN	_	11	dep	_	_
19	of	of	IN	IN	_	21	case	_	_
20	cytokine	cytokine	NN	NN	_	21	compound	_	_
21	synthesis	synthesis	NN	NN	_	18	nmod	_	_
22	)	)	-RRB-	-RRB-	_	18	punct	_	_
23	and	and	CC	CC	_	11	cc	_	_
24	simultaneously	simultaneously	RB	RB	_	25	advmod	_	_
25	measure	measure	VB	VB	_	11	conj	_	_
26	the	the	DT	DT	_	27	det	_	_
27	frequency	frequency	NN	NN	_	25	dobj	_	_
28	of	of	IN	IN	_	29	case	_	_
29	cells	cell	NNS	NNS	_	27	nmod	_	_
30	directed	direct	VBN	VBN	_	29	acl	_	_
31	against	against	IN	IN	_	32	case	_	_
32	them	they	PRP	PRP	_	30	nmod	_	_
33	.	.	.	.	_	9	punct	_	_

1	For	for	IN	IN	_	3	case	_	_
2	this	this	DT	DT	_	3	det	_	_
3	purpose	purpose	NN	NN	_	16	nmod	_	_
4	,	,	,	,	_	16	punct	_	_
5	81	81	CD	CD	_	7	nummod	_	_
6	pentadecamer	pentadecamer	NN	NN	_	7	compound	_	_
7	peptides	peptide	NNS	NNS	_	16	nsubjpass	_	_
8	covering	cover	VBG	VBG	_	7	acl	_	_
9	the	the	DT	DT	_	12	det	_	_
10	complete	complete	JJ	JJ	_	12	amod	_	_
11	491-amino-acid	491-amino-acid	NN	NN	_	12	compound	_	_
12	sequence	sequence	NN	NN	_	8	dobj	_	_
13	of	of	IN	IN	_	14	case	_	_
14	IE-1	ie-1	NN	NN	_	12	nmod	_	_
15	were	be	VBD	VBD	_	16	auxpass	_	_
16	tested	test	VBN	VBN	_	0	root	_	_
17	on	on	IN	IN	_	21	case	_	_
18	peripheral	peripheral	JJ	JJ	_	21	amod	_	_
19	blood	blood	NN	NN	_	21	compound	_	_
20	mononuclear	mononuclear	JJ	JJ	_	21	amod	_	_
21	cells	cell	NNS	NNS	_	16	nmod	_	_
22	of	of	IN	IN	_	26	case	_	_
23	anti-HCMV	anti-hcmv	NN	NN	_	26	compound	_	_
24	immunoglobulin	immunoglobulin	NN	NN	_	26	compound	_	_
25	G-seropositive	g-seropositive	JJ	JJ	_	26	amod	_	_
26	donors	donor	NNS	NNS	_	21	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	At	at	IN	IN	_	2	case	_	_
2	least	least	JJS	JJS	_	3	nmod:npmod	_	_
3	10	10	CD	CD	_	5	nummod	_	_
4	new	new	JJ	JJ	_	5	amod	_	_
5	epitopes	epitope	NNS	NNS	_	7	nsubjpass	_	_
6	were	be	VBD	VBD	_	7	auxpass	_	_
7	identified	identify	VBN	VBN	_	0	root	_	_
8	,	,	,	,	_	7	punct	_	_
9	and	and	CC	CC	_	7	cc	_	_
10	the	the	DT	DT	_	12	det	_	_
11	fine	fine	NN	NN	_	12	compound	_	_
12	specificity	specificity	NN	NN	_	23	nsubjpass	_	_
13	and	and	CC	CC	_	12	cc	_	_
14	presenting	presenting	JJ	JJ	_	16	amod	_	_
15	HLA	hla	NN	NN	_	16	compound	_	_
16	molecule	molecule	NN	NN	_	12	conj	_	_
17	of	of	IN	IN	_	19	case	_	_
18	the	the	DT	DT	_	19	det	_	_
19	first	first	JJ	JJ	_	16	nmod	_	_
20	of	of	IN	IN	_	21	case	_	_
21	them	they	PRP	PRP	_	19	nmod	_	_
22	was	be	VBD	VBD	_	23	auxpass	_	_
23	determined	determine	VBN	VBN	_	7	conj	_	_
24	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	frequencies	frequency	NNS	NNS	_	11	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	CD8(+)	cd8(+)	JJ	JJ	_	6	amod	_	_
5	T	t	NN	NN	_	6	compound	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	directed	direct	VBN	VBN	_	6	acl	_	_
8	against	against	IN	IN	_	9	case	_	_
9	IE-1	ie-1	NN	NN	_	7	nmod	_	_
10	were	be	VBD	VBD	_	11	cop	_	_
11	similar	similar	JJ	JJ	_	0	root	_	_
12	to	to	TO	TO	_	13	case	_	_
13	those	those	DT	DT	_	11	nmod	_	_
14	directed	direct	VBN	VBN	_	13	acl	_	_
15	against	against	IN	IN	_	16	case	_	_
16	pp65	pp65	NN	NN	_	14	nmod	_	_
17	in	in	IN	IN	_	18	case	_	_
18	donors	donor	NNS	NNS	_	11	nmod	_	_
19	tested	test	VBN	VBN	_	18	acl	_	_
20	with	with	IN	IN	_	23	case	_	_
21	known	known	JJ	JJ	_	23	amod	_	_
22	pp65-derived	pp65-derived	JJ	JJ	_	23	amod	_	_
23	peptides	peptide	NNS	NNS	_	19	nmod	_	_
24	.	.	.	.	_	11	punct	_	_

1	Importantly	importantly	RB	RB	_	22	advmod	_	_
2	,	,	,	,	_	22	punct	_	_
3	additional	additional	JJ	JJ	_	4	amod	_	_
4	testing	testing	NN	NN	_	22	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	a	a	DT	DT	_	8	det	_	_
7	corresponding	corresponding	JJ	JJ	_	8	amod	_	_
8	set	set	NN	NN	_	4	nmod	_	_
9	of	of	IN	IN	_	10	case	_	_
10	peptides	peptide	NNS	NNS	_	8	nmod	_	_
11	covering	cover	VBG	VBG	_	10	acl	_	_
12	the	the	DT	DT	_	14	det	_	_
13	complete	complete	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	pp65	pp65	NN	NN	_	14	nmod	_	_
17	on	on	IN	IN	_	18	case	_	_
18	10	10	CD	CD	_	4	nmod	_	_
19	of	of	IN	IN	_	21	case	_	_
20	these	these	DT	DT	_	21	det	_	_
21	donors	donor	NNS	NNS	_	18	nmod	_	_
22	identified	identify	VBD	VBD	_	0	root	_	_
23	individuals	individual	NNS	NNS	_	22	dobj	_	_
24	whose	whose	WP$	WP$	_	27	nmod:poss	_	_
25	CD8(+)	cd8(+)	JJ	JJ	_	27	amod	_	_
26	T	t	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	28	nsubj	_	_
28	recognized	recognize	VBD	VBD	_	23	acl:relcl	_	_
29	IE-1	ie-1	NN	NN	_	28	dobj	_	_
30	but	but	CC	CC	_	29	cc	_	_
31	not	not	RB	RB	_	32	neg	_	_
32	pp65	pp65	NN	NN	_	29	conj	_	_
33	and	and	CC	CC	_	22	cc	_	_
34	vice	vice	RB	RB	_	35	advmod	_	_
35	versa	versa	RB	RB	_	38	advmod	_	_
36	,	,	,	,	_	38	punct	_	_
37	clearly	clearly	RB	RB	_	38	advmod	_	_
38	illustrating	illustrate	VBG	VBG	_	22	conj	_	_
39	that	that	IN	IN	_	46	mark	_	_
40	either	either	DT	DT	_	41	det	_	_
41	protein	protein	NN	NN	_	46	nsubj	_	_
42	may	may	MD	MD	_	46	aux	_	_
43	be	be	VB	VB	_	46	cop	_	_
44	a	a	DT	DT	_	46	det	_	_
45	major	major	JJ	JJ	_	46	amod	_	_
46	target	target	NN	NN	_	38	ccomp	_	_
47	.	.	.	.	_	22	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	summary	summary	NN	NN	_	6	nmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	results	result	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	12	mark	_	_
8	IE-1	ie-1	NN	NN	_	12	nsubj	_	_
9	is	be	VBZ	VBZ	_	12	cop	_	_
10	far	far	RB	RB	_	12	advmod	_	_
11	more	more	RBR	RBR	_	12	advmod	_	_
12	important	important	JJ	JJ	_	6	ccomp	_	_
13	as	as	IN	IN	_	16	case	_	_
14	a	a	DT	DT	_	16	det	_	_
15	CD8(+)-T-cell	cd8(+)-t-cell	NN	NN	_	16	compound	_	_
16	target	target	NN	NN	_	12	nmod	_	_
17	than	than	IN	IN	_	20	mark	_	_
18	current	current	JJ	JJ	_	19	amod	_	_
19	opinion	opinion	NN	NN	_	20	nsubj	_	_
20	suggests	suggest	VBZ	VBZ	_	12	ccomp	_	_
21	.	.	.	.	_	6	punct	_	_

1	Inhibition	inhibition	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	5	case	_	_
3	protein	protein	NN	NN	_	5	compound	_	_
4	phosphatase	phosphatase	NN	NN	_	5	compound	_	_
5	2A	2a	NN	NN	_	1	nmod	_	_
6	induces	induce	VBZ	VBZ	_	0	root	_	_
7	serine/threonine	serine/threonine	JJ	JJ	_	8	amod	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	subcellular	subcellular	JJ	JJ	_	11	amod	_	_
11	redistribution	redistribution	NN	NN	_	8	conj	_	_
12	,	,	,	,	_	8	punct	_	_
13	and	and	CC	CC	_	8	cc	_	_
14	functional	functional	JJ	JJ	_	15	amod	_	_
15	inhibition	inhibition	NN	NN	_	8	conj	_	_
16	of	of	IN	IN	_	17	case	_	_
17	STAT3	stat3	NN	NN	_	15	nmod	_	_
18	.	.	.	.	_	6	punct	_	_

1	Signal	signal	NN	NN	_	2	compound	_	_
2	transducers	transducer	NNS	NNS	_	12	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	activators	activator	NNS	NNS	_	6	compound	_	_
5	of	of	IN	IN	_	6	amod	_	_
6	transcription	transcription	NN	NN	_	2	conj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	STATs	stats	NNS	NNS	_	2	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	are	be	VBP	VBP	_	12	auxpass	_	_
11	rapidly	rapidly	RB	RB	_	12	advmod	_	_
12	phosphorylated	phosphorylate	VBN	VBN	_	0	root	_	_
13	on	on	IN	IN	_	15	case	_	_
14	tyrosine	tyrosine	NN	NN	_	15	compound	_	_
15	residues	residue	NNS	NNS	_	12	nmod	_	_
16	in	in	IN	IN	_	17	case	_	_
17	response	response	NN	NN	_	12	nmod	_	_
18	to	to	TO	TO	_	19	case	_	_
19	cytokine	cytokine	NN	NN	_	17	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	growth	growth	NN	NN	_	22	compound	_	_
22	factor	factor	NN	NN	_	19	conj	_	_
23	stimulation	stimulation	NN	NN	_	19	dep	_	_
24	of	of	IN	IN	_	27	case	_	_
25	cell	cell	NN	NN	_	27	compound	_	_
26	surface	surface	NN	NN	_	27	compound	_	_
27	receptors	receptor	NNS	NNS	_	19	nmod	_	_
28	.	.	.	.	_	12	punct	_	_

1	STATs	stats	NNS	NNS	_	4	nsubjpass	_	_
2	hereafter	hereafter	RB	RB	_	4	advmod	_	_
3	are	be	VBP	VBP	_	4	auxpass	_	_
4	translocated	translocate	VBN	VBN	_	0	root	_	_
5	to	to	TO	TO	_	7	case	_	_
6	the	the	DT	DT	_	7	det	_	_
7	nucleus	nucleus	NN	NN	_	4	nmod	_	_
8	where	where	WRB	WRB	_	9	advmod	_	_
9	they	they	PRP	PRP	_	7	acl:relcl	_	_
10	act	act	VBP	VBP	_	13	dep	_	_
11	as	as	IN	IN	_	13	case	_	_
12	transcription	transcription	NN	NN	_	13	compound	_	_
13	factors	factor	NNS	NNS	_	9	advcl	_	_
14	.	.	.	.	_	4	punct	_	_

1	Recent	recent	JJ	JJ	_	2	amod	_	_
2	reports	report	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	11	mark	_	_
5	serine	serine	NN	NN	_	6	compound	_	_
6	phosphorylation	phosphorylation	NN	NN	_	11	nsubjpass	_	_
7	of	of	IN	IN	_	8	case	_	_
8	STATs	stats	NNS	NNS	_	6	nmod	_	_
9	also	also	RB	RB	_	11	advmod	_	_
10	is	be	VBZ	VBZ	_	11	auxpass	_	_
11	involved	involve	VBN	VBN	_	3	ccomp	_	_
12	in	in	IN	IN	_	14	case	_	_
13	the	the	DT	DT	_	14	det	_	_
14	regulation	regulation	NN	NN	_	11	nmod	_	_
15	of	of	IN	IN	_	18	case	_	_
16	STAT-mediated	stat-mediated	JJ	JJ	_	18	amod	_	_
17	gene	gene	NN	NN	_	18	compound	_	_
18	transcription	transcription	NN	NN	_	14	nmod	_	_
19	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	studied	study	VBD	VBD	_	0	root	_	_
5	the	the	DT	DT	_	6	det	_	_
6	role	role	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	serine/threonine	serine/threonine	JJ	JJ	_	9	amod	_	_
9	phosphatases	phosphatase	NNS	NNS	_	6	nmod	_	_
10	in	in	IN	IN	_	12	case	_	_
11	STAT3	stat3	NN	NN	_	12	compound	_	_
12	signaling	signaling	NN	NN	_	6	nmod	_	_
13	in	in	IN	IN	_	19	case	_	_
14	human	human	JJ	JJ	_	19	amod	_	_
15	antigen-specific	antigen-specific	JJ	JJ	_	19	amod	_	_
16	CD4(+)	cd4(+)	JJ	JJ	_	19	amod	_	_
17	T	t	NN	NN	_	19	compound	_	_
18	cell	cell	NN	NN	_	19	compound	_	_
19	lines	line	NNS	NNS	_	4	nmod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	cutaneous	cutaneous	JJ	JJ	_	25	amod	_	_
22	T	t	NN	NN	_	25	compound	_	_
23	cell	cell	NN	NN	_	25	compound	_	_
24	lymphoma	lymphoma	NN	NN	_	25	compound	_	_
25	lines	line	NNS	NNS	_	19	conj	_	_
26	,	,	,	,	_	25	punct	_	_
27	expressing	express	VBG	VBG	_	25	acl	_	_
28	a	a	DT	DT	_	31	det	_	_
29	constitutively	constitutively	RB	RB	_	31	advmod	_	_
30	activated	activate	VBN	VBN	_	31	amod	_	_
31	STAT3	stat3	NN	NN	_	27	dobj	_	_
32	.	.	.	.	_	4	punct	_	_

1	We	we	PRP	PRP	_	2	nsubj	_	_
2	show	show	VBP	VBP	_	0	root	_	_
3	that	that	IN	IN	_	17	mark	_	_
4	an	a	DT	DT	_	5	det	_	_
5	inhibitor	inhibitor	NN	NN	_	17	nsubj	_	_
6	of	of	IN	IN	_	8	case	_	_
7	protein	protein	NN	NN	_	8	compound	_	_
8	phosphatases	phosphatase	NNS	NNS	_	5	nmod	_	_
9	(	(	-LRB-	-LRB-	_	10	punct	_	_
10	PPs	pp	NNS	NNS	_	8	appos	_	_
11	)	)	-RRB-	-RRB-	_	10	punct	_	_
12	PP1/PP2A	pp1/pp2a	NN	NN	_	5	dep	_	_
13	,	,	,	,	_	12	punct	_	_
14	calyculin	calyculin	NN	NN	_	15	compound	_	_
15	A	a	NN	NN	_	12	appos	_	_
16	,	,	,	,	_	12	punct	_	_
17	induces	induce	VBZ	VBZ	_	2	ccomp	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	i	i	LS	LS	_	21	dep	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	phosphorylation	phosphorylation	NN	NN	_	17	dobj	_	_
22	of	of	IN	IN	_	23	case	_	_
23	STAT3	stat3	NN	NN	_	21	nmod	_	_
24	on	on	IN	IN	_	25	case	_	_
25	serine	serine	NN	NN	_	21	nmod	_	_
26	and	and	CC	CC	_	25	cc	_	_
27	threonine	threonine	NN	NN	_	25	conj	_	_
28	residues	residue	NNS	NNS	_	25	dep	_	_
29	,	,	,	,	_	21	punct	_	_
30	(	(	-LRB-	-LRB-	_	31	punct	_	_
31	ii	ii	LS	LS	_	33	dep	_	_
32	)	)	-RRB-	-RRB-	_	31	punct	_	_
33	inhibition	inhibition	NN	NN	_	21	conj	_	_
34	of	of	IN	IN	_	37	case	_	_
35	STAT3	stat3	NN	NN	_	37	compound	_	_
36	tyrosine	tyrosine	NN	NN	_	37	compound	_	_
37	phosphorylation	phosphorylation	NN	NN	_	33	nmod	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	DNA	dna	NN	NN	_	41	compound	_	_
40	binding	binding	NN	NN	_	41	compound	_	_
41	activity	activity	NN	NN	_	37	conj	_	_
42	,	,	,	,	_	21	punct	_	_
43	and	and	CC	CC	_	21	cc	_	_
44	(	(	-LRB-	-LRB-	_	45	punct	_	_
45	iii	iii	LS	LS	_	47	dep	_	_
46	)	)	-RRB-	-RRB-	_	45	punct	_	_
47	relocation	relocation	NN	NN	_	21	conj	_	_
48	of	of	IN	IN	_	49	case	_	_
49	STAT3	stat3	NN	NN	_	47	nmod	_	_
50	from	from	IN	IN	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	nucleus	nucleus	NN	NN	_	47	nmod	_	_
53	to	to	TO	TO	_	55	case	_	_
54	the	the	DT	DT	_	55	det	_	_
55	cytoplasm	cytoplasm	NN	NN	_	52	nmod	_	_
56	.	.	.	.	_	2	punct	_	_

1	Similar	similar	JJ	JJ	_	2	amod	_	_
2	results	result	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	other	other	JJ	JJ	_	8	amod	_	_
7	PP2A	pp2a	NN	NN	_	8	compound	_	_
8	inhibitors	inhibitor	NNS	NNS	_	4	nmod	_	_
9	(	(	-LRB-	-LRB-	_	11	punct	_	_
10	okadaic	okadaic	JJ	JJ	_	11	amod	_	_
11	acid	acid	NN	NN	_	8	dep	_	_
12	,	,	,	,	_	11	punct	_	_
13	endothall	endothall	NN	NN	_	14	compound	_	_
14	thioanhydride	thioanhydride	NN	NN	_	11	appos	_	_
15	)	)	-RRB-	-RRB-	_	11	punct	_	_
16	but	but	CC	CC	_	8	cc	_	_
17	not	not	RB	RB	_	19	neg	_	_
18	with	with	IN	IN	_	19	case	_	_
19	inhibitors	inhibitor	NNS	NNS	_	8	conj	_	_
20	of	of	IN	IN	_	21	case	_	_
21	PP1	pp1	NN	NN	_	19	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	tautomycin	tautomycin	NN	NN	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	or	or	CC	CC	_	21	cc	_	_
26	PP2B	pp2b	NN	NN	_	21	conj	_	_
27	(	(	-LRB-	-LRB-	_	29	punct	_	_
28	cyclosporine	cyclosporine	NN	NN	_	29	compound	_	_
29	A	a	NN	NN	_	26	appos	_	_
30	)	)	-RRB-	-RRB-	_	29	punct	_	_
31	.	.	.	.	_	4	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	10	nsubj	_	_
2	with	with	IN	IN	_	8	case	_	_
3	the	the	DT	DT	_	8	det	_	_
4	broad	broad	JJ	JJ	_	8	amod	_	_
5	serine/threonine	serine/threonine	JJ	JJ	_	8	amod	_	_
6	kinase	kinase	NN	NN	_	8	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	8	compound	_	_
8	staurosporine	staurosporine	NN	NN	_	1	nmod	_	_
9	partly	partly	RB	RB	_	10	advmod	_	_
10	blocked	block	VBD	VBD	_	0	root	_	_
11	the	the	DT	DT	_	15	det	_	_
12	calyculin	calyculin	NN	NN	_	15	compound	_	_
13	A-induced	a-induced	JJ	JJ	_	15	amod	_	_
14	STAT3	stat3	NN	NN	_	15	compound	_	_
15	phosphorylation	phosphorylation	NN	NN	_	10	dobj	_	_
16	,	,	,	,	_	10	punct	_	_
17	whereas	whereas	IN	IN	_	10	dep	_	_
18	inhibitors	inhibitor	NNS	NNS	_	40	nsubj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	serine/threonine	serine/threonine	NN	NN	_	21	compound	_	_
21	kinases	kinase	NNS	NNS	_	18	nmod	_	_
22	,	,	,	,	_	18	punct	_	_
23	such	such	JJ	JJ	_	29	case	_	_
24	as	as	IN	IN	_	29	case	_	_
25	mitogen-activated	mitogen-activated	JJ	JJ	_	29	amod	_	_
26	protein	protein	NN	NN	_	29	compound	_	_
27	kinase-1	kinase-1	NN	NN	_	29	compound	_	_
28	extracellular-regulated	extracellular-regulated	JJ	JJ	_	29	amod	_	_
29	kinase-kinase	kinase-kinase	NN	NN	_	18	nmod	_	_
30	,	,	,	,	_	29	punct	_	_
31	mitogen-activated	mitogen-activated	JJ	JJ	_	34	amod	_	_
32	protein	protein	NN	NN	_	34	compound	_	_
33	p38	p38	NN	NN	_	34	compound	_	_
34	kinase	kinase	NN	NN	_	29	conj	_	_
35	,	,	,	,	_	29	punct	_	_
36	and	and	CC	CC	_	29	cc	_	_
37	phosphatidylinositol	phosphatidylinositol	NN	NN	_	38	compound	_	_
38	3-kinase	3-kinase	NN	NN	_	29	conj	_	_
39	,	,	,	,	_	18	punct	_	_
40	did	do	VBD	VBD	_	10	parataxis	_	_
41	not	not	RB	RB	_	40	neg	_	_
42	.	.	.	.	_	10	punct	_	_

1	In	in	IN	IN	_	2	case	_	_
2	conclusion	conclusion	NN	NN	_	5	nmod	_	_
3	,	,	,	,	_	5	punct	_	_
4	we	we	PRP	PRP	_	5	nsubj	_	_
5	provide	provide	VBP	VBP	_	0	root	_	_
6	evidence	evidence	NN	NN	_	5	dobj	_	_
7	that	that	IN	IN	_	9	mark	_	_
8	PP2A	pp2a	NN	NN	_	9	nsubj	_	_
9	plays	play	VBZ	VBZ	_	6	dep	_	_
10	a	a	DT	DT	_	12	det	_	_
11	crucial	crucial	JJ	JJ	_	12	amod	_	_
12	role	role	NN	NN	_	9	dobj	_	_
13	in	in	IN	IN	_	15	case	_	_
14	the	the	DT	DT	_	15	det	_	_
15	regulation	regulation	NN	NN	_	9	nmod	_	_
16	of	of	IN	IN	_	18	case	_	_
17	STAT3	stat3	NN	NN	_	18	compound	_	_
18	phosphorylation	phosphorylation	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	subcellular	subcellular	JJ	JJ	_	21	amod	_	_
21	distribution	distribution	NN	NN	_	15	conj	_	_
22	in	in	IN	IN	_	24	case	_	_
23	T	t	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	21	nmod	_	_
25	.	.	.	.	_	5	punct	_	_

1	Moreover	moreover	RB	RB	_	5	advmod	_	_
2	,	,	,	,	_	5	punct	_	_
3	our	we	PRP$	PRP$	_	4	nmod:poss	_	_
4	findings	finding	NNS	NNS	_	5	nsubj	_	_
5	suggest	suggest	VBP	VBP	_	0	root	_	_
6	that	that	IN	IN	_	13	mark	_	_
7	the	the	DT	DT	_	8	det	_	_
8	level	level	NN	NN	_	13	nsubj	_	_
9	of	of	IN	IN	_	11	case	_	_
10	STAT3	stat3	NN	NN	_	11	compound	_	_
11	phosphorylation	phosphorylation	NN	NN	_	8	nmod	_	_
12	is	be	VBZ	VBZ	_	13	aux	_	_
13	balanced	balanced	JJ	JJ	_	5	ccomp	_	_
14	between	between	IN	IN	_	19	case	_	_
15	a	a	DT	DT	_	19	det	_	_
16	staurosporine-sensitive	staurosporine-sensitive	JJ	JJ	_	19	amod	_	_
17	kinase	kinase	NN	NN	_	19	compound	_	_
18	(	(	-LRB-	-LRB-	_	19	punct	_	_
19	s	s	NNS	NNS	_	13	nmod	_	_
20	)	)	-RRB-	-RRB-	_	19	punct	_	_
21	and	and	CC	CC	_	19	cc	_	_
22	PP2A	pp2a	NN	NN	_	19	conj	_	_
23	.	.	.	.	_	5	punct	_	_

1	Interferons	interferon	NNS	NNS	_	2	nsubj	_	_
2	inhibit	inhibit	VBP	VBP	_	0	root	_	_
3	activation	activation	NN	NN	_	2	dobj	_	_
4	of	of	IN	IN	_	5	case	_	_
5	STAT6	stat6	NN	NN	_	3	nmod	_	_
6	by	by	IN	IN	_	7	case	_	_
7	interleukin	interleukin	NN	NN	_	3	nmod	_	_
8	4	4	CD	CD	_	7	nummod	_	_
9	in	in	IN	IN	_	11	case	_	_
10	human	human	JJ	JJ	_	11	amod	_	_
11	monocytes	monocyte	NNS	NNS	_	3	nmod	_	_
12	by	by	IN	IN	_	13	mark	_	_
13	inducing	induce	VBG	VBG	_	2	advcl	_	_
14	SOCS-1	socs-1	NN	NN	_	16	compound	_	_
15	gene	gene	NN	NN	_	16	compound	_	_
16	expression	expression	NN	NN	_	13	dobj	_	_
17	.	.	.	.	_	2	punct	_	_

1	Interferons	interferon	NNS	NNS	_	5	nsubj	_	_
2	(	(	-LRB-	-LRB-	_	3	punct	_	_
3	IFNs	ifn	NNS	NNS	_	1	appos	_	_
4	)	)	-RRB-	-RRB-	_	3	punct	_	_
5	inhibit	inhibit	VBP	VBP	_	0	root	_	_
6	induction	induction	NN	NN	_	5	dobj	_	_
7	by	by	IN	IN	_	8	case	_	_
8	IL-4	il-4	NN	NN	_	6	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	multiple	multiple	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	in	in	IN	IN	_	14	case	_	_
13	human	human	JJ	JJ	_	14	amod	_	_
14	monocytes	monocyte	NNS	NNS	_	11	nmod	_	_
15	.	.	.	.	_	5	punct	_	_

1	However	however	RB	RB	_	14	advmod	_	_
2	,	,	,	,	_	14	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	mechanism	mechanism	NN	NN	_	14	nsubjpass	_	_
5	by	by	IN	IN	_	6	case	_	_
6	which	which	WDT	WDT	_	8	nmod	_	_
7	IFNs	ifn	NNS	NNS	_	8	nsubj	_	_
8	mediate	mediate	VBP	VBP	_	4	acl:relcl	_	_
9	this	this	DT	DT	_	10	det	_	_
10	inhibition	inhibition	NN	NN	_	8	dobj	_	_
11	has	have	VBZ	VBZ	_	14	aux	_	_
12	not	not	RB	RB	_	14	neg	_	_
13	been	be	VBN	VBN	_	14	auxpass	_	_
14	defined	define	VBN	VBN	_	0	root	_	_
15	.	.	.	.	_	14	punct	_	_

1	IL-4	il-4	NN	NN	_	2	nsubj	_	_
2	activates	activate	VBZ	VBZ	_	0	root	_	_
3	gene	gene	NN	NN	_	4	compound	_	_
4	expression	expression	NN	NN	_	2	dobj	_	_
5	by	by	IN	IN	_	6	mark	_	_
6	inducing	induce	VBG	VBG	_	2	advcl	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	6	dobj	_	_
9	,	,	,	,	_	8	punct	_	_
10	homodimerization	homodimerization	NN	NN	_	8	conj	_	_
11	,	,	,	,	_	8	punct	_	_
12	and	and	CC	CC	_	8	cc	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	translocation	translocation	NN	NN	_	8	conj	_	_
15	of	of	IN	IN	_	19	case	_	_
16	the	the	DT	DT	_	19	det	_	_
17	latent	latent	JJ	JJ	_	19	amod	_	_
18	transcription	transcription	NN	NN	_	19	compound	_	_
19	factor	factor	NN	NN	_	8	nmod	_	_
20	,	,	,	,	_	19	punct	_	_
21	STAT6	stat6	NN	NN	_	19	appos	_	_
22	(	(	-LRB-	-LRB-	_	24	punct	_	_
23	signal	signal	JJ	JJ	_	24	amod	_	_
24	transducer	transducer	NN	NN	_	21	dep	_	_
25	and	and	CC	CC	_	24	cc	_	_
26	activator	activator	NN	NN	_	28	compound	_	_
27	of	of	IN	IN	_	28	amod	_	_
28	transcription-6	transcription-6	NN	NN	_	24	conj	_	_
29	)	)	-RRB-	-RRB-	_	24	punct	_	_
30	.	.	.	.	_	2	punct	_	_

1	STAT6-responsive	stat6-responsive	JJ	JJ	_	2	amod	_	_
2	elements	element	NNS	NNS	_	5	nsubj	_	_
3	are	be	VBP	VBP	_	5	cop	_	_
4	characteristically	characteristically	RB	RB	_	5	advmod	_	_
5	present	present	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	promoters	promoter	NNS	NNS	_	5	nmod	_	_
9	of	of	IN	IN	_	11	case	_	_
10	IL-4-inducible	il-4-inducible	JJ	JJ	_	11	amod	_	_
11	genes	gene	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Because	because	IN	IN	_	5	mark	_	_
2	STAT6	stat6	NN	NN	_	3	compound	_	_
3	activation	activation	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	12	advcl	_	_
6	for	for	IN	IN	_	9	case	_	_
7	IL-4-induced	il-4-induced	JJ	JJ	_	9	amod	_	_
8	gene	gene	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	5	nmod	_	_
10	,	,	,	,	_	12	punct	_	_
11	we	we	PRP	PRP	_	12	nsubj	_	_
12	examined	examine	VBD	VBD	_	0	root	_	_
13	the	the	DT	DT	_	14	det	_	_
14	ability	ability	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	type	type	NN	NN	_	12	nmod	_	_
17	I	i	CD	CD	_	16	nummod	_	_
18	and	and	CC	CC	_	16	cc	_	_
19	type	type	NN	NN	_	16	conj	_	_
20	II	ii	CD	CD	_	19	nummod	_	_
21	IFNs	ifn	NNS	NNS	_	16	dep	_	_
22	to	to	TO	TO	_	23	mark	_	_
23	regulate	regulate	VB	VB	_	12	advcl	_	_
24	activation	activation	NN	NN	_	23	dobj	_	_
25	of	of	IN	IN	_	26	case	_	_
26	STAT6	stat6	NN	NN	_	24	nmod	_	_
27	by	by	IN	IN	_	28	case	_	_
28	IL-4	il-4	NN	NN	_	24	nmod	_	_
29	in	in	IN	IN	_	32	case	_	_
30	primary	primary	JJ	JJ	_	32	amod	_	_
31	human	human	JJ	JJ	_	32	amod	_	_
32	monocytes	monocyte	NNS	NNS	_	24	nmod	_	_
33	.	.	.	.	_	12	punct	_	_

1	Pretreatment	pretreatment	NN	NN	_	30	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	monocytes	monocyte	NNS	NNS	_	1	nmod	_	_
4	with	with	IN	IN	_	5	case	_	_
5	IFN-beta	ifn-beta	NN	NN	_	1	nmod	_	_
6	or	or	CC	CC	_	5	cc	_	_
7	IFN-gamma	ifn-gamma	NN	NN	_	5	conj	_	_
8	,	,	,	,	_	5	punct	_	_
9	but	but	CC	CC	_	5	cc	_	_
10	not	not	RB	RB	_	11	neg	_	_
11	IL-1	il-1	NN	NN	_	5	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	IL-2	il-2	NN	NN	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	macrophage	macrophage	NN	NN	_	17	compound	_	_
16	colony-stimulating	colony-stimulating	JJ	JJ	_	17	amod	_	_
17	factor	factor	NN	NN	_	11	conj	_	_
18	,	,	,	,	_	11	punct	_	_
19	granulocyte/macrophage	granulocyte/macrophage	JJ	JJ	_	21	amod	_	_
20	colony-stimulating	colony-stimulating	JJ	JJ	_	21	amod	_	_
21	factor	factor	NN	NN	_	11	conj	_	_
22	,	,	,	,	_	11	punct	_	_
23	IL-6	il-6	NN	NN	_	11	conj	_	_
24	,	,	,	,	_	11	punct	_	_
25	or	or	CC	CC	_	11	cc	_	_
26	transforming	transform	VBG	VBG	_	29	amod	_	_
27	growth	growth	NN	NN	_	29	compound	_	_
28	factor	factor	IN	IN	_	29	amod	_	_
29	beta	beta	NN	NN	_	11	conj	_	_
30	suppressed	suppress	VBD	VBD	_	0	root	_	_
31	activation	activation	NN	NN	_	30	dobj	_	_
32	of	of	IN	IN	_	33	case	_	_
33	STAT6	stat6	NN	NN	_	31	nmod	_	_
34	by	by	IN	IN	_	35	case	_	_
35	IL-4	il-4	NN	NN	_	31	nmod	_	_
36	.	.	.	.	_	30	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	inhibition	inhibition	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	associated	associate	VBN	VBN	_	0	root	_	_
5	with	with	IN	IN	_	8	case	_	_
6	decreased	decrease	VBN	VBN	_	8	amod	_	_
7	tyrosine	tyrosine	NN	NN	_	8	compound	_	_
8	phosphorylation	phosphorylation	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	nuclear	nuclear	JJ	JJ	_	11	amod	_	_
11	translocation	translocation	NN	NN	_	8	conj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	STAT6	stat6	NN	NN	_	11	nmod	_	_
14	and	and	CC	CC	_	4	cc	_	_
15	was	be	VBD	VBD	_	17	cop	_	_
16	not	not	RB	RB	_	17	neg	_	_
17	evident	evident	JJ	JJ	_	4	conj	_	_
18	unless	unless	IN	IN	_	22	mark	_	_
19	the	the	DT	DT	_	20	det	_	_
20	cells	cell	NNS	NNS	_	22	nsubjpass	_	_
21	were	be	VBD	VBD	_	22	auxpass	_	_
22	preincubated	preincubate	VBN	VBN	_	17	ccomp	_	_
23	with	with	IN	IN	_	24	case	_	_
24	IFN	ifn	NN	NN	_	22	nmod	_	_
25	for	for	IN	IN	_	29	case	_	_
26	at	at	IN	IN	_	27	case	_	_
27	least	least	JJS	JJS	_	28	nmod:npmod	_	_
28	1	1	CD	CD	_	29	nummod	_	_
29	hr	hr	NN	NN	_	22	nmod	_	_
30	before	before	IN	IN	_	32	case	_	_
31	IL-4	il-4	NN	NN	_	32	compound	_	_
32	stimulation	stimulation	NN	NN	_	29	nmod	_	_
33	.	.	.	.	_	4	punct	_	_

1	Furthermore	furthermore	RB	RB	_	8	advmod	_	_
2	,	,	,	,	_	8	punct	_	_
3	inhibition	inhibition	NN	NN	_	8	nsubjpass	_	_
4	by	by	IN	IN	_	5	case	_	_
5	IFN	ifn	NN	NN	_	3	nmod	_	_
6	could	could	MD	MD	_	8	aux	_	_
7	be	be	VB	VB	_	8	auxpass	_	_
8	blocked	block	VBN	VBN	_	0	root	_	_
9	by	by	IN	IN	_	10	case	_	_
10	cotreatment	cotreatment	NN	NN	_	8	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	actinomycin	actinomycin	NN	NN	_	13	compound	_	_
13	D	d	NN	NN	_	10	nmod	_	_
14	and	and	CC	CC	_	8	cc	_	_
15	correlated	correlate	VBN	VBN	_	8	conj	_	_
16	temporally	temporally	RB	RB	_	15	advmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	induction	induction	NN	NN	_	15	nmod	_	_
19	of	of	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	JAK/STAT	jak/stat	NN	NN	_	23	compound	_	_
22	inhibitory	inhibitory	JJ	JJ	_	23	amod	_	_
23	gene	gene	NN	NN	_	18	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	SOCS-1	socs-1	NN	NN	_	23	appos	_	_
26	.	.	.	.	_	8	punct	_	_

1	Forced	force	VBN	VBN	_	2	amod	_	_
2	expression	expression	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	SOCS-1	socs-1	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	9	case	_	_
6	a	a	DT	DT	_	9	det	_	_
7	macrophage	macrophage	JJ	JJ	_	9	amod	_	_
8	cell	cell	NN	NN	_	9	compound	_	_
9	line	line	NN	NN	_	2	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	RAW264	raw264	NN	NN	_	9	appos	_	_
12	,	,	,	,	_	9	punct	_	_
13	markedly	markedly	RB	RB	_	14	advmod	_	_
14	suppressed	suppress	VBD	VBD	_	0	root	_	_
15	trans-activation	trans-activation	NN	NN	_	14	dobj	_	_
16	of	of	IN	IN	_	19	case	_	_
17	an	a	DT	DT	_	19	det	_	_
18	IL-4-inducible	il-4-inducible	JJ	JJ	_	19	amod	_	_
19	reporter	reporter	NN	NN	_	15	nmod	_	_
20	as	as	RB	RB	_	15	cc	_	_
21	well	well	RB	RB	_	20	mwe	_	_
22	as	as	IN	IN	_	20	mwe	_	_
23	IL-6-	il-6-	NN	NN	_	28	amod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	IFN-gamma-induced	ifn-gamma-induced	JJ	JJ	_	26	dep	_	_
26	reporter	reporter	NN	NN	_	23	conj	_	_
27	gene	gene	NN	NN	_	28	compound	_	_
28	activity	activity	NN	NN	_	15	conj	_	_
29	.	.	.	.	_	14	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	findings	finding	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	IFNs	ifn	NNS	NNS	_	6	nsubj	_	_
6	inhibit	inhibit	VBP	VBP	_	3	ccomp	_	_
7	IL-4-induced	il-4-induced	JJ	JJ	_	8	amod	_	_
8	activation	activation	NN	NN	_	6	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	STAT6	stat6	NN	NN	_	8	nmod	_	_
11	and	and	CC	CC	_	8	cc	_	_
12	STAT6-dependent	stat6-dependent	JJ	JJ	_	14	amod	_	_
13	gene	gene	NN	NN	_	14	compound	_	_
14	expression	expression	NN	NN	_	8	conj	_	_
15	,	,	,	,	_	6	punct	_	_
16	at	at	IN	IN	_	6	advcl	_	_
17	least	least	JJS	JJS	_	16	mwe	_	_
18	in	in	IN	IN	_	19	case	_	_
19	part	part	NN	NN	_	16	nmod	_	_
20	,	,	,	,	_	6	punct	_	_
21	by	by	IN	IN	_	22	mark	_	_
22	inducing	induce	VBG	VBG	_	6	advcl	_	_
23	expression	expression	NN	NN	_	22	dobj	_	_
24	of	of	IN	IN	_	25	case	_	_
25	SOCS-1	socs-1	NN	NN	_	23	nmod	_	_
26	.	.	.	.	_	3	punct	_	_

1	Increased	increase	VBN	VBN	_	3	amod	_	_
2	IkappaB	ikappab	NN	NN	_	3	compound	_	_
3	expression	expression	NN	NN	_	0	root	_	_
4	and	and	CC	CC	_	3	cc	_	_
5	diminished	diminish	VBN	VBN	_	7	amod	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	3	conj	_	_
8	in	in	IN	IN	_	11	case	_	_
9	human	human	JJ	JJ	_	11	amod	_	_
10	mononuclear	mononuclear	JJ	JJ	_	11	amod	_	_
11	cells	cell	NNS	NNS	_	3	nmod	_	_
12	following	follow	VBG	VBG	_	14	case	_	_
13	hydrocortisone	hydrocortisone	NN	NN	_	14	compound	_	_
14	injection	injection	NN	NN	_	3	nmod	_	_
15	.	.	.	.	_	3	punct	_	_

1	We	we	PRP	PRP	_	4	nsubj	_	_
2	have	have	VBP	VBP	_	4	aux	_	_
3	recently	recently	RB	RB	_	4	advmod	_	_
4	demonstrated	demonstrate	VBN	VBN	_	0	root	_	_
5	that	that	IN	IN	_	10	mark	_	_
6	hydrocortisone	hydrocortisone	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	other	other	JJ	JJ	_	9	amod	_	_
9	glucocorticoids	glucocorticoid	NNS	NNS	_	6	conj	_	_
10	inhibit	inhibit	VBP	VBP	_	4	ccomp	_	_
11	reactive	reactive	JJ	JJ	_	13	amod	_	_
12	oxygen	oxygen	NN	NN	_	13	compound	_	_
13	species	species	NNS	NNS	_	17	compound	_	_
14	(	(	-LRB-	-LRB-	_	15	punct	_	_
15	ROS	ros	NN	NN	_	13	appos	_	_
16	)	)	-RRB-	-RRB-	_	15	punct	_	_
17	generation	generation	NN	NN	_	10	dobj	_	_
18	by	by	IN	IN	_	21	case	_	_
19	mononuclear	mononuclear	JJ	JJ	_	21	amod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	MNC	mnc	NN	NN	_	17	nmod	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	and	and	CC	CC	_	21	cc	_	_
24	polymorphonuclear	polymorphonuclear	JJ	JJ	_	25	amod	_	_
25	leucocytes	leucocyte	NNS	NNS	_	21	conj	_	_
26	(	(	-LRB-	-LRB-	_	27	punct	_	_
27	PMNL	pmnl	NN	NN	_	25	appos	_	_
28	)	)	-RRB-	-RRB-	_	27	punct	_	_
29	.	.	.	.	_	4	punct	_	_

1	Since	since	IN	IN	_	4	mark	_	_
2	NF-kappaB/IkappaB	nf-kappab/ikappab	JJ	JJ	_	3	amod	_	_
3	system	system	NN	NN	_	4	nsubj	_	_
4	regulates	regulate	VBZ	VBZ	_	19	advcl	_	_
5	the	the	DT	DT	_	6	det	_	_
6	transcription	transcription	NN	NN	_	4	dobj	_	_
7	of	of	IN	IN	_	9	case	_	_
8	proinflammatory	proinflammatory	JJ	JJ	_	9	amod	_	_
9	genes	gene	NNS	NNS	_	6	nmod	_	_
10	,	,	,	,	_	9	punct	_	_
11	including	include	VBG	VBG	_	12	case	_	_
12	those	those	DT	DT	_	9	nmod	_	_
13	responsible	responsible	JJ	JJ	_	12	amod	_	_
14	for	for	IN	IN	_	16	case	_	_
15	ROS	ros	NN	NN	_	16	compound	_	_
16	generation	generation	NN	NN	_	13	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	we	we	PRP	PRP	_	19	nsubj	_	_
19	tested	test	VBD	VBD	_	0	root	_	_
20	the	the	DT	DT	_	21	det	_	_
21	hypothesis	hypothesis	NN	NN	_	19	dobj	_	_
22	that	that	IN	IN	_	25	mark	_	_
23	hydrocortisone	hydrocortisone	NN	NN	_	25	nsubj	_	_
24	may	may	MD	MD	_	25	aux	_	_
25	stimulate	stimulate	VB	VB	_	21	dep	_	_
26	IkappaB	ikappab	NN	NN	_	27	compound	_	_
27	production	production	NN	NN	_	25	dobj	_	_
28	thus	thus	RB	RB	_	29	advmod	_	_
29	inhibiting	inhibit	VBG	VBG	_	25	xcomp	_	_
30	NF-kappaB	nf-kappab	NN	NN	_	31	compound	_	_
31	translocation	translocation	NN	NN	_	29	dobj	_	_
32	from	from	IN	IN	_	34	case	_	_
33	the	the	DT	DT	_	34	det	_	_
34	cytosol	cytosol	NN	NN	_	29	nmod	_	_
35	into	into	IN	IN	_	37	case	_	_
36	the	the	DT	DT	_	37	det	_	_
37	nucleus	nucleus	NN	NN	_	34	nmod	_	_
38	in	in	IN	IN	_	39	case	_	_
39	MNC	mnc	NN	NN	_	37	nmod	_	_
40	,	,	,	,	_	29	punct	_	_
41	in	in	FW	FW	_	42	compound	_	_
42	vivo	vivo	FW	FW	_	29	advmod	_	_
43	.	.	.	.	_	19	punct	_	_

1	One	one	CD	CD	_	3	nummod	_	_
2	hundred	hundred	CD	CD	_	3	nummod	_	_
3	milligram	milligram	NN	NN	_	7	nsubjpass	_	_
4	of	of	IN	IN	_	5	case	_	_
5	hydrocortisone	hydrocortisone	NN	NN	_	3	nmod	_	_
6	was	be	VBD	VBD	_	7	auxpass	_	_
7	injected	inject	VBN	VBN	_	0	root	_	_
8	intravenously	intravenously	RB	RB	_	7	advmod	_	_
9	into	into	IN	IN	_	12	case	_	_
10	4	4	CD	CD	_	12	nummod	_	_
11	normal	normal	JJ	JJ	_	12	amod	_	_
12	subjects	subject	NNS	NNS	_	7	nmod	_	_
13	.	.	.	.	_	7	punct	_	_

1	Blood	blood	NN	NN	_	2	compound	_	_
2	samples	sample	NNS	NNS	_	4	nsubjpass	_	_
3	were	be	VBD	VBD	_	4	auxpass	_	_
4	obtained	obtain	VBN	VBN	_	0	root	_	_
5	prior	prior	JJ	JJ	_	8	case	_	_
6	to	to	TO	TO	_	8	case	_	_
7	the	the	DT	DT	_	8	det	_	_
8	injection	injection	NN	NN	_	4	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	at	at	IN	IN	_	20	case	_	_
11	1	1	CD	CD	_	20	compound	_	_
12	,	,	,	,	_	11	punct	_	_
13	2	2	CD	CD	_	11	conj	_	_
14	,	,	,	,	_	11	punct	_	_
15	4	4	CD	CD	_	11	conj	_	_
16	,	,	,	,	_	11	punct	_	_
17	8	8	CD	CD	_	11	conj	_	_
18	and	and	CC	CC	_	11	cc	_	_
19	24	24	CD	CD	_	11	conj	_	_
20	hr	hr	NN	NN	_	8	conj	_	_
21	after	after	IN	IN	_	23	case	_	_
22	the	the	DT	DT	_	23	det	_	_
23	injection	injection	NN	NN	_	20	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	Nuclear	nuclear	JJ	JJ	_	2	amod	_	_
2	extracts	extract	NNS	NNS	_	8	nsubjpass	_	_
3	and	and	CC	CC	_	2	cc	_	_
4	total	total	JJ	JJ	_	6	amod	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	lysates	lysate	NNS	NNS	_	2	conj	_	_
7	were	be	VBD	VBD	_	8	auxpass	_	_
8	prepared	prepare	VBN	VBN	_	0	root	_	_
9	from	from	IN	IN	_	10	case	_	_
10	MNC	mnc	NN	NN	_	8	nmod	_	_
11	by	by	IN	IN	_	13	case	_	_
12	standard	standard	JJ	JJ	_	13	amod	_	_
13	techniques	technique	NNS	NNS	_	8	nmod	_	_
14	.	.	.	.	_	8	punct	_	_

1	IkappaB	ikappab	NN	NN	_	2	compound	_	_
2	levels	level	NNS	NNS	_	6	nsubj	_	_
3	in	in	IN	IN	_	5	case	_	_
4	MNC	mnc	NN	NN	_	5	compound	_	_
5	homogenates	homogenate	NNS	NNS	_	2	nmod	_	_
6	increased	increase	VBD	VBD	_	0	root	_	_
7	at	at	IN	IN	_	9	case	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	hr	hr	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	peaked	peak	VBD	VBD	_	6	conj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	2-4	2-4	CD	CD	_	14	nummod	_	_
14	hr	hr	NN	NN	_	11	nmod	_	_
15	,	,	,	,	_	6	punct	_	_
16	started	start	VBD	VBD	_	6	conj	_	_
17	to	to	TO	TO	_	18	mark	_	_
18	decrease	decrease	VB	VB	_	16	xcomp	_	_
19	at	at	IN	IN	_	21	case	_	_
20	8	8	CD	CD	_	21	nummod	_	_
21	hr	hr	NN	NN	_	18	nmod	_	_
22	,	,	,	,	_	6	punct	_	_
23	and	and	CC	CC	_	6	cc	_	_
24	returned	return	VBD	VBD	_	6	conj	_	_
25	to	to	TO	TO	_	27	case	_	_
26	baseline	baseline	NN	NN	_	27	compound	_	_
27	levels	level	NNS	NNS	_	24	nmod	_	_
28	at	at	IN	IN	_	30	case	_	_
29	24	24	CD	CD	_	30	nummod	_	_
30	hr	hr	NN	NN	_	24	nmod	_	_
31	.	.	.	.	_	6	punct	_	_

1	NF-kappaB	nf-kappab	NN	NN	_	6	nsubj	_	_
2	in	in	IN	IN	_	5	case	_	_
3	MNC	mnc	NN	NN	_	5	compound	_	_
4	nuclear	nuclear	JJ	JJ	_	5	amod	_	_
5	extracts	extract	NNS	NNS	_	1	nmod	_	_
6	decreased	decrease	VBD	VBD	_	0	root	_	_
7	at	at	IN	IN	_	9	case	_	_
8	1	1	CD	CD	_	9	nummod	_	_
9	hr	hr	NN	NN	_	6	nmod	_	_
10	,	,	,	,	_	6	punct	_	_
11	reached	reach	VBD	VBD	_	6	conj	_	_
12	a	a	DT	DT	_	13	det	_	_
13	nadir	nadir	NN	NN	_	11	dobj	_	_
14	at	at	IN	IN	_	16	case	_	_
15	4	4	CD	CD	_	16	nummod	_	_
16	hr	hr	NN	NN	_	11	nmod	_	_
17	,	,	,	,	_	6	punct	_	_
18	gradually	gradually	RB	RB	_	19	advmod	_	_
19	increased	increase	VBD	VBD	_	6	conj	_	_
20	at	at	IN	IN	_	22	case	_	_
21	8	8	CD	CD	_	22	nummod	_	_
22	hr	hr	NN	NN	_	19	nmod	_	_
23	and	and	CC	CC	_	6	cc	_	_
24	returned	return	VBD	VBD	_	6	conj	_	_
25	back	back	RB	RB	_	24	advmod	_	_
26	to	to	TO	TO	_	28	case	_	_
27	baseline	baseline	NN	NN	_	28	compound	_	_
28	levels	level	NNS	NNS	_	25	nmod	_	_
29	at	at	IN	IN	_	31	case	_	_
30	24	24	CD	CD	_	31	nummod	_	_
31	hr	hr	NN	NN	_	24	nmod	_	_
32	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	total	total	JJ	JJ	_	4	amod	_	_
3	protein	protein	NN	NN	_	4	compound	_	_
4	content	content	NN	NN	_	15	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	NF-kappaB	nf-kappab	NN	NN	_	7	compound	_	_
7	subunit	subunit	NN	NN	_	4	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	P65	p65	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	in	in	IN	IN	_	13	case	_	_
12	MNC	mnc	NN	NN	_	13	compound	_	_
13	lysates	lysate	NNS	NNS	_	7	nmod	_	_
14	also	also	RB	RB	_	15	advmod	_	_
15	showed	show	VBD	VBD	_	0	root	_	_
16	a	a	DT	DT	_	17	det	_	_
17	decrease	decrease	NN	NN	_	15	dobj	_	_
18	following	follow	VBG	VBG	_	20	case	_	_
19	hydrocortisone	hydrocortisone	NN	NN	_	20	compound	_	_
20	injection	injection	NN	NN	_	15	nmod	_	_
21	.	.	.	.	_	15	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	decrease	decrease	NN	NN	_	4	nsubjpass	_	_
3	was	be	VBD	VBD	_	4	auxpass	_	_
4	observed	observe	VBN	VBN	_	0	root	_	_
5	at	at	IN	IN	_	7	case	_	_
6	2	2	CD	CD	_	7	nummod	_	_
7	hr	hr	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	reached	reach	VBD	VBD	_	4	conj	_	_
10	a	a	DT	DT	_	11	det	_	_
11	nadir	nadir	NN	NN	_	9	dobj	_	_
12	at	at	IN	IN	_	14	case	_	_
13	4	4	CD	CD	_	14	nummod	_	_
14	hr	hr	NN	NN	_	9	nmod	_	_
15	,	,	,	,	_	4	punct	_	_
16	and	and	CC	CC	_	4	cc	_	_
17	returned	return	VBD	VBD	_	4	conj	_	_
18	to	to	TO	TO	_	20	case	_	_
19	baseline	baseline	NN	NN	_	20	compound	_	_
20	levels	level	NNS	NNS	_	17	nmod	_	_
21	at	at	IN	IN	_	23	case	_	_
22	24	24	CD	CD	_	23	nummod	_	_
23	hr	hr	NN	NN	_	17	nmod	_	_
24	.	.	.	.	_	4	punct	_	_

1	ROS	ros	NN	NN	_	3	compound	_	_
2	generation	generation	NN	NN	_	3	compound	_	_
3	inhibition	inhibition	NN	NN	_	4	nsubj	_	_
4	paralleled	parallel	VBD	VBD	_	0	root	_	_
5	NF-kappaB	nf-kappab	NN	NN	_	6	compound	_	_
6	levels	level	NNS	NNS	_	4	dobj	_	_
7	in	in	IN	IN	_	9	case	_	_
8	the	the	DT	DT	_	9	det	_	_
9	nucleus	nucleus	NN	NN	_	6	nmod	_	_
10	.	.	.	.	_	4	punct	_	_

1	It	it	PRP	PRP	_	3	nsubjpass	_	_
2	was	be	VBD	VBD	_	3	auxpass	_	_
3	inhibited	inhibit	VBN	VBN	_	0	root	_	_
4	at	at	IN	IN	_	6	case	_	_
5	1	1	CD	CD	_	6	nummod	_	_
6	hr	hr	NN	NN	_	3	nmod	_	_
7	,	,	,	,	_	3	punct	_	_
8	reached	reach	VBD	VBD	_	3	conj	_	_
9	a	a	DT	DT	_	10	det	_	_
10	nadir	nadir	NN	NN	_	8	dobj	_	_
11	at	at	IN	IN	_	13	case	_	_
12	2-4	2-4	CD	CD	_	13	nummod	_	_
13	hr	hr	NN	NN	_	8	nmod	_	_
14	,	,	,	,	_	3	punct	_	_
15	started	start	VBD	VBD	_	3	conj	_	_
16	to	to	TO	TO	_	17	mark	_	_
17	increase	increase	VB	VB	_	15	xcomp	_	_
18	at	at	IN	IN	_	20	case	_	_
19	8	8	CD	CD	_	20	nummod	_	_
20	hr	hr	NN	NN	_	17	nmod	_	_
21	,	,	,	,	_	3	punct	_	_
22	and	and	CC	CC	_	3	cc	_	_
23	returned	return	VBD	VBD	_	3	conj	_	_
24	to	to	TO	TO	_	26	case	_	_
25	basal	basal	JJ	JJ	_	26	amod	_	_
26	levels	level	NNS	NNS	_	23	nmod	_	_
27	at	at	IN	IN	_	29	case	_	_
28	24	24	CD	CD	_	29	nummod	_	_
29	hr	hr	NN	NN	_	23	nmod	_	_
30	.	.	.	.	_	3	punct	_	_

1	Our	we	PRP$	PRP$	_	2	nmod:poss	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	6	mark	_	_
5	hydrocortisone	hydrocortisone	NN	NN	_	6	nsubj	_	_
6	induces	induce	VBZ	VBZ	_	3	ccomp	_	_
7	IkappaB	ikappab	NN	NN	_	6	dobj	_	_
8	and	and	CC	CC	_	6	cc	_	_
9	suppresses	suppress	VBZ	VBZ	_	6	conj	_	_
10	NF-kappaB	nf-kappab	NN	NN	_	11	compound	_	_
11	expression	expression	NN	NN	_	9	dobj	_	_
12	in	in	IN	IN	_	13	case	_	_
13	MNC	mnc	NN	NN	_	11	nmod	_	_
14	in	in	IN	IN	_	15	case	_	_
15	parallel	parallel	NN	NN	_	9	nmod	_	_
16	.	.	.	.	_	3	punct	_	_

1	IkappaB	ikappab	NN	NN	_	3	nsubj	_	_
2	further	further	RB	RB	_	3	advmod	_	_
3	reduces	reduce	VBZ	VBZ	_	0	root	_	_
4	the	the	DT	DT	_	5	det	_	_
5	translocation	translocation	NN	NN	_	3	dobj	_	_
6	of	of	IN	IN	_	7	case	_	_
7	NF-kappaB	nf-kappab	NN	NN	_	5	nmod	_	_
8	into	into	IN	IN	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	nucleus	nucleus	NN	NN	_	5	nmod	_	_
11	thus	thus	RB	RB	_	12	advmod	_	_
12	preventing	prevent	VBG	VBG	_	3	xcomp	_	_
13	the	the	DT	DT	_	14	det	_	_
14	expression	expression	NN	NN	_	12	dobj	_	_
15	of	of	IN	IN	_	17	case	_	_
16	proinflammatory	proinflammatory	JJ	JJ	_	17	amod	_	_
17	genes	gene	NNS	NNS	_	14	nmod	_	_
18	.	.	.	.	_	3	punct	_	_

1	Activation	activation	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	CDC42	cdc42	NN	NN	_	6	compound	_	_
5	effector	effector	NN	NN	_	6	compound	_	_
6	N-WASP	n-wasp	NN	NN	_	1	nmod	_	_
7	by	by	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	Shigella	shigella	NN	NN	_	12	compound	_	_
10	flexneri	flexneri	NN	NN	_	12	compound	_	_
11	IcsA	icsa	NN	NN	_	12	compound	_	_
12	protein	protein	NN	NN	_	1	nmod	_	_
13	promotes	promote	VBZ	VBZ	_	0	root	_	_
14	actin	actin	NN	NN	_	15	compound	_	_
15	nucleation	nucleation	NN	NN	_	13	dobj	_	_
16	by	by	IN	IN	_	18	case	_	_
17	Arp2/3	arp2/3	NN	NN	_	18	compound	_	_
18	complex	complex	NN	NN	_	15	nmod	_	_
19	and	and	CC	CC	_	15	cc	_	_
20	bacterial	bacterial	JJ	JJ	_	22	amod	_	_
21	actin-based	actin-based	JJ	JJ	_	22	amod	_	_
22	motility	motility	NN	NN	_	15	conj	_	_
23	.	.	.	.	_	13	punct	_	_

1	To	to	TO	TO	_	2	mark	_	_
2	propel	propel	VB	VB	_	12	advcl	_	_
3	itself	itself	PRP	PRP	_	2	dobj	_	_
4	in	in	IN	IN	_	6	case	_	_
5	infected	infected	JJ	JJ	_	6	amod	_	_
6	cells	cell	NNS	NNS	_	2	nmod	_	_
7	,	,	,	,	_	12	punct	_	_
8	the	the	DT	DT	_	11	det	_	_
9	pathogen	pathogen	NN	NN	_	11	compound	_	_
10	Shigella	shigella	NN	NN	_	11	compound	_	_
11	flexneri	flexneri	NN	NN	_	12	nsubj	_	_
12	subverts	subvert	VBZ	VBZ	_	0	root	_	_
13	the	the	DT	DT	_	15	det	_	_
14	Cdc42-controlled	cdc42-controlled	JJ	JJ	_	15	amod	_	_
15	machinery	machinery	NN	NN	_	12	dobj	_	_
16	responsible	responsible	JJ	JJ	_	15	amod	_	_
17	for	for	IN	IN	_	19	case	_	_
18	actin	actin	NN	NN	_	19	compound	_	_
19	assembly	assembly	NN	NN	_	16	nmod	_	_
20	during	during	IN	IN	_	22	case	_	_
21	filopodia	filopodia	NN	NN	_	22	compound	_	_
22	formation	formation	NN	NN	_	12	nmod	_	_
23	.	.	.	.	_	12	punct	_	_

1	Using	use	VBG	VBG	_	31	advcl	_	_
2	a	a	DT	DT	_	3	det	_	_
3	combination	combination	NN	NN	_	1	dobj	_	_
4	of	of	IN	IN	_	7	case	_	_
5	bacterial	bacterial	JJ	JJ	_	7	amod	_	_
6	motility	motility	NN	NN	_	7	compound	_	_
7	assays	assay	NNS	NNS	_	3	nmod	_	_
8	in	in	IN	IN	_	10	case	_	_
9	platelet	platelet	NN	NN	_	10	compound	_	_
10	extracts	extract	NNS	NNS	_	7	nmod	_	_
11	with	with	IN	IN	_	13	case	_	_
12	Escherichia	escherichia	FW	FW	_	13	compound	_	_
13	coli	coli	FW	FW	_	10	nmod	_	_
14	expressing	express	VBG	VBG	_	13	acl	_	_
15	the	the	DT	DT	_	18	det	_	_
16	Shigella	shigella	NN	NN	_	18	compound	_	_
17	IcsA	icsa	NN	NN	_	18	compound	_	_
18	protein	protein	NN	NN	_	14	dobj	_	_
19	and	and	CC	CC	_	7	cc	_	_
20	in	in	FW	FW	_	22	amod	_	_
21	vitro	vitro	FW	FW	_	20	dep	_	_
22	analysis	analysis	NN	NN	_	7	conj	_	_
23	of	of	IN	IN	_	25	case	_	_
24	reconstituted	reconstitute	VBN	VBN	_	25	amod	_	_
25	systems	system	NNS	NNS	_	22	nmod	_	_
26	from	from	IN	IN	_	28	case	_	_
27	purified	purify	VBN	VBN	_	28	amod	_	_
28	proteins	protein	NNS	NNS	_	25	nmod	_	_
29	,	,	,	,	_	31	punct	_	_
30	we	we	PRP	PRP	_	31	nsubj	_	_
31	show	show	VBP	VBP	_	0	root	_	_
32	here	here	RB	RB	_	31	advmod	_	_
33	that	that	IN	IN	_	38	mark	_	_
34	the	the	DT	DT	_	37	det	_	_
35	bacterial	bacterial	JJ	JJ	_	37	amod	_	_
36	protein	protein	NN	NN	_	37	compound	_	_
37	IcsA	icsa	NN	NN	_	38	nsubj	_	_
38	binds	bind	VBZ	VBZ	_	31	ccomp	_	_
39	N-WASP	n-wasp	NN	NN	_	38	dobj	_	_
40	and	and	CC	CC	_	38	cc	_	_
41	activates	activate	VBZ	VBZ	_	38	conj	_	_
42	it	it	PRP	PRP	_	41	dobj	_	_
43	in	in	IN	IN	_	46	case	_	_
44	a	a	DT	DT	_	46	det	_	_
45	Cdc42-like	cdc42-like	JJ	JJ	_	46	amod	_	_
46	fashion	fashion	NN	NN	_	41	nmod	_	_
47	.	.	.	.	_	31	punct	_	_

1	Dramatic	dramatic	JJ	JJ	_	2	amod	_	_
2	stimulation	stimulation	NN	NN	_	7	nsubjpass	_	_
3	of	of	IN	IN	_	5	case	_	_
4	actin	actin	NN	NN	_	5	compound	_	_
5	assembly	assembly	NN	NN	_	2	nmod	_	_
6	is	be	VBZ	VBZ	_	7	auxpass	_	_
7	linked	link	VBN	VBN	_	0	root	_	_
8	to	to	TO	TO	_	10	case	_	_
9	the	the	DT	DT	_	10	det	_	_
10	formation	formation	NN	NN	_	7	nmod	_	_
11	of	of	IN	IN	_	20	case	_	_
12	a	a	DT	DT	_	15	det	_	_
13	ternary	ternary	JJ	JJ	_	15	amod	_	_
14	IcsA-N-WASP-Arp2/3	icsa-n-wasp-arp2/3	NN	NN	_	15	compound	_	_
15	complex	complex	NN	NN	_	20	compound	_	_
16	,	,	,	,	_	20	punct	_	_
17	which	which	WDT	WDT	_	20	det	_	_
18	nucleates	nucleate	VBZ	VBZ	_	20	dep	_	_
19	actin	actin	NN	NN	_	20	compound	_	_
20	polymerization	polymerization	NN	NN	_	10	nmod	_	_
21	.	.	.	.	_	7	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	Arp2/3	arp2/3	NN	NN	_	3	compound	_	_
3	complex	complex	NN	NN	_	5	nsubj	_	_
4	is	be	VBZ	VBZ	_	5	cop	_	_
5	essential	essential	JJ	JJ	_	0	root	_	_
6	in	in	IN	IN	_	7	case	_	_
7	initiation	initiation	NN	NN	_	5	nmod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	actin	actin	NN	NN	_	10	compound	_	_
10	assembly	assembly	NN	NN	_	7	nmod	_	_
11	and	and	CC	CC	_	10	cc	_	_
12	Shigella	shigella	NN	NN	_	13	compound	_	_
13	movement	movement	NN	NN	_	10	conj	_	_
14	,	,	,	,	_	5	punct	_	_
15	as	as	IN	IN	_	5	advcl	_	_
16	previously	previously	RB	RB	_	15	advmod	_	_
17	observed	observe	VBN	VBN	_	15	dep	_	_
18	for	for	IN	IN	_	15	dep	_	_
19	Listeria	listeria	NN	NN	_	15	dep	_	_
20	monocytogenes	monocytogene	NNS	NNS	_	15	dep	_	_
21	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	6	nsubj	_	_
2	of	of	IN	IN	_	3	case	_	_
3	N-WASP	n-wasp	NN	NN	_	1	nmod	_	_
4	by	by	IN	IN	_	5	case	_	_
5	IcsA	icsa	NN	NN	_	1	nmod	_	_
6	unmasks	unmask	VBZ	VBZ	_	0	root	_	_
7	two	two	CD	CD	_	8	nummod	_	_
8	domains	domain	NNS	NNS	_	6	dobj	_	_
9	acting	act	VBG	VBG	_	8	acl	_	_
10	together	together	RB	RB	_	9	advmod	_	_
11	in	in	IN	IN	_	14	case	_	_
12	insertional	insertional	JJ	JJ	_	14	amod	_	_
13	actin	actin	NN	NN	_	14	compound	_	_
14	polymerization	polymerization	NN	NN	_	9	nmod	_	_
15	.	.	.	.	_	6	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	isolated	isolate	VBN	VBN	_	4	amod	_	_
3	COOH-terminal	cooh-terminal	JJ	JJ	_	4	amod	_	_
4	domain	domain	NN	NN	_	24	nsubj	_	_
5	of	of	IN	IN	_	6	case	_	_
6	N-WASP	n-wasp	NN	NN	_	4	nmod	_	_
7	containing	contain	VBG	VBG	_	6	acl	_	_
8	a	a	DT	DT	_	10	det	_	_
9	verprolin-homology	verprolin-homology	JJ	JJ	_	10	amod	_	_
10	region	region	NN	NN	_	7	dobj	_	_
11	,	,	,	,	_	10	punct	_	_
12	a	a	DT	DT	_	14	det	_	_
13	cofilin-homology	cofilin-homology	JJ	JJ	_	14	amod	_	_
14	sequence	sequence	NN	NN	_	10	conj	_	_
15	,	,	,	,	_	10	punct	_	_
16	and	and	CC	CC	_	10	cc	_	_
17	an	a	DT	DT	_	20	det	_	_
18	acidic	acidic	JJ	JJ	_	20	amod	_	_
19	terminal	terminal	JJ	JJ	_	20	amod	_	_
20	segment	segment	NN	NN	_	10	conj	_	_
21	(	(	-LRB-	-LRB-	_	22	punct	_	_
22	VCA	vca	NN	NN	_	10	appos	_	_
23	)	)	-RRB-	-RRB-	_	22	punct	_	_
24	interacts	interact	VBZ	VBZ	_	0	root	_	_
25	with	with	IN	IN	_	26	case	_	_
26	G-actin	g-actin	NN	NN	_	24	nmod	_	_
27	in	in	IN	IN	_	32	case	_	_
28	a	a	DT	DT	_	32	det	_	_
29	unique	unique	JJ	JJ	_	32	amod	_	_
30	profilin-like	profilin-like	JJ	JJ	_	32	amod	_	_
31	functional	functional	JJ	JJ	_	32	amod	_	_
32	fashion	fashion	NN	NN	_	24	nmod	_	_
33	.	.	.	.	_	24	punct	_	_

1	Hence	hence	RB	RB	_	11	advmod	_	_
2	,	,	,	,	_	11	punct	_	_
3	when	when	WRB	WRB	_	6	advmod	_	_
4	N-WASP	n-wasp	NN	NN	_	6	nsubjpass	_	_
5	is	be	VBZ	VBZ	_	6	auxpass	_	_
6	activated	activate	VBN	VBN	_	11	advcl	_	_
7	,	,	,	,	_	11	punct	_	_
8	its	its	PRP$	PRP$	_	10	nmod:poss	_	_
9	COOH-terminal	cooh-terminal	JJ	JJ	_	10	amod	_	_
10	domain	domain	NN	NN	_	11	nsubj	_	_
11	feeds	feed	VBZ	VBZ	_	0	root	_	_
12	barbed	barb	VBN	VBN	_	14	amod	_	_
13	end	end	NN	NN	_	14	compound	_	_
14	growth	growth	NN	NN	_	11	dobj	_	_
15	of	of	IN	IN	_	16	case	_	_
16	filaments	filament	NNS	NNS	_	14	nmod	_	_
17	and	and	CC	CC	_	11	cc	_	_
18	lowers	lower	VBZ	VBZ	_	11	conj	_	_
19	the	the	DT	DT	_	21	det	_	_
20	critical	critical	JJ	JJ	_	21	amod	_	_
21	concentration	concentration	NN	NN	_	18	dobj	_	_
22	at	at	IN	IN	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	bacterial	bacterial	JJ	JJ	_	25	amod	_	_
25	surface	surface	NN	NN	_	18	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	On	on	IN	IN	_	4	case	_	_
2	the	the	DT	DT	_	4	det	_	_
3	other	other	JJ	JJ	_	4	amod	_	_
4	hand	hand	NN	NN	_	11	nmod	_	_
5	,	,	,	,	_	11	punct	_	_
6	the	the	DT	DT	_	8	det	_	_
7	NH(2)-terminal	nh(2)-terminal	JJ	JJ	_	8	amod	_	_
8	domain	domain	NN	NN	_	11	nsubj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	N-WASP	n-wasp	NN	NN	_	8	nmod	_	_
11	interacts	interact	VBZ	VBZ	_	0	root	_	_
12	with	with	IN	IN	_	13	case	_	_
13	F-actin	f-actin	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	11	punct	_	_
15	mediating	mediate	VBG	VBG	_	11	xcomp	_	_
16	the	the	DT	DT	_	17	det	_	_
17	attachment	attachment	NN	NN	_	15	dobj	_	_
18	of	of	IN	IN	_	21	case	_	_
19	the	the	DT	DT	_	21	det	_	_
20	actin	actin	NN	NN	_	21	compound	_	_
21	tail	tail	NN	NN	_	17	nmod	_	_
22	to	to	TO	TO	_	25	case	_	_
23	the	the	DT	DT	_	25	det	_	_
24	bacterium	bacterium	NN	NN	_	25	compound	_	_
25	surface	surface	NN	NN	_	17	nmod	_	_
26	.	.	.	.	_	11	punct	_	_

1	VASP	vasp	NN	NN	_	4	nsubjpass	_	_
2	is	be	VBZ	VBZ	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	involved	involve	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	7	case	_	_
6	Shigella	shigella	NN	NN	_	7	compound	_	_
7	movement	movement	NN	NN	_	4	nmod	_	_
8	,	,	,	,	_	4	punct	_	_
9	and	and	CC	CC	_	4	cc	_	_
10	the	the	DT	DT	_	11	det	_	_
11	function	function	NN	NN	_	16	nsubj	_	_
12	of	of	IN	IN	_	13	case	_	_
13	profilin	profilin	NN	NN	_	11	nmod	_	_
14	does	do	VBZ	VBZ	_	16	aux	_	_
15	not	not	RB	RB	_	16	neg	_	_
16	require	require	VB	VB	_	4	conj	_	_
17	its	its	PRP$	PRP$	_	18	nmod:poss	_	_
18	binding	binding	NN	NN	_	16	dobj	_	_
19	to	to	TO	TO	_	21	case	_	_
20	proline-rich	proline-rich	JJ	JJ	_	21	amod	_	_
21	regions	region	NNS	NNS	_	18	nmod	_	_
22	.	.	.	.	_	4	punct	_	_

1	Renal	renal	JJ	JJ	_	4	amod	_	_
2	cell	cell	NN	NN	_	4	compound	_	_
3	carcinoma-derived	carcinoma-derived	JJ	JJ	_	4	amod	_	_
4	gangliosides	ganglioside	NNS	NNS	_	5	nsubj	_	_
5	suppress	suppress	VBP	VBP	_	0	root	_	_
6	nuclear	nuclear	JJ	JJ	_	8	amod	_	_
7	factor-kappaB	factor-kappab	NN	NN	_	8	compound	_	_
8	activation	activation	NN	NN	_	5	dobj	_	_
9	in	in	IN	IN	_	11	case	_	_
10	T	t	NN	NN	_	11	compound	_	_
11	cells	cell	NNS	NNS	_	8	nmod	_	_
12	.	.	.	.	_	5	punct	_	_

1	Activation	activation	NN	NN	_	12	nsubj	_	_
2	of	of	IN	IN	_	7	case	_	_
3	the	the	DT	DT	_	7	det	_	_
4	transcription	transcription	NN	NN	_	7	compound	_	_
5	factor	factor	NN	NN	_	7	compound	_	_
6	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
7	factor-kappaB	factor-kappab	NN	NN	_	1	nmod	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	NFkappaB	nfkappab	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	12	aux	_	_
12	impaired	impaired	JJ	JJ	_	0	root	_	_
13	in	in	IN	IN	_	15	case	_	_
14	T	t	NN	NN	_	15	compound	_	_
15	cells	cell	NNS	NNS	_	12	nmod	_	_
16	from	from	IN	IN	_	17	case	_	_
17	patients	patient	NNS	NNS	_	15	nmod	_	_
18	with	with	IN	IN	_	21	case	_	_
19	renal	renal	JJ	JJ	_	21	amod	_	_
20	cell	cell	NN	NN	_	21	compound	_	_
21	carcinomas	carcinoma	NNS	NNS	_	17	nmod	_	_
22	(	(	-LRB-	-LRB-	_	23	punct	_	_
23	RCCs	rcc	NNS	NNS	_	21	appos	_	_
24	)	)	-RRB-	-RRB-	_	23	punct	_	_
25	.	.	.	.	_	12	punct	_	_

1	In	in	IN	IN	_	2	mark	_	_
2	circulating	circulate	VBG	VBG	_	20	advcl	_	_
3	T	t	NN	NN	_	4	compound	_	_
4	cells	cell	NNS	NNS	_	2	dobj	_	_
5	from	from	IN	IN	_	7	case	_	_
6	a	a	DT	DT	_	7	det	_	_
7	subset	subset	NN	NN	_	2	nmod	_	_
8	of	of	IN	IN	_	9	case	_	_
9	patients	patient	NNS	NNS	_	7	nmod	_	_
10	with	with	IN	IN	_	11	case	_	_
11	RCCs	rcc	NNS	NNS	_	9	nmod	_	_
12	,	,	,	,	_	20	punct	_	_
13	the	the	DT	DT	_	14	det	_	_
14	suppression	suppression	NN	NN	_	20	nsubj	_	_
15	of	of	IN	IN	_	18	case	_	_
16	NFkappaB	nfkappab	NN	NN	_	18	compound	_	_
17	binding	binding	NN	NN	_	18	compound	_	_
18	activity	activity	NN	NN	_	14	nmod	_	_
19	is	be	VBZ	VBZ	_	20	cop	_	_
20	downstream	downstream	JJ	JJ	_	0	root	_	_
21	from	from	IN	IN	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	stimulus-induced	stimulus-induced	JJ	JJ	_	24	amod	_	_
24	degradation	degradation	NN	NN	_	20	nmod	_	_
25	of	of	IN	IN	_	29	case	_	_
26	the	the	DT	DT	_	29	det	_	_
27	cytoplasmic	cytoplasmic	JJ	JJ	_	29	amod	_	_
28	factor	factor	NN	NN	_	29	compound	_	_
29	IkappaBalpha	ikappabalpha	NN	NN	_	24	nmod	_	_
30	.	.	.	.	_	20	punct	_	_

1	Tumor-derived	tumor-derived	JJ	JJ	_	3	amod	_	_
2	soluble	soluble	JJ	JJ	_	3	amod	_	_
3	products	product	NNS	NNS	_	8	nsubj	_	_
4	from	from	IN	IN	_	7	case	_	_
5	cultured	culture	VBN	VBN	_	7	amod	_	_
6	RCC	rcc	NN	NN	_	7	compound	_	_
7	explants	explant	NNS	NNS	_	3	nmod	_	_
8	inhibit	inhibit	VBP	VBP	_	0	root	_	_
9	NFkappaB	nfkappab	NN	NN	_	10	compound	_	_
10	activity	activity	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	13	case	_	_
12	T	t	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	10	nmod	_	_
14	from	from	IN	IN	_	16	case	_	_
15	healthy	healthy	JJ	JJ	_	16	amod	_	_
16	volunteers	volunteer	NNS	NNS	_	13	nmod	_	_
17	,	,	,	,	_	8	punct	_	_
18	despite	despite	IN	IN	_	21	case	_	_
19	a	a	DT	DT	_	21	det	_	_
20	normal	normal	JJ	JJ	_	21	amod	_	_
21	level	level	NN	NN	_	8	nmod	_	_
22	of	of	IN	IN	_	25	case	_	_
23	stimulus-induced	stimulus-induced	JJ	JJ	_	25	amod	_	_
24	IkappaBalpha	ikappabalpha	NN	NN	_	25	compound	_	_
25	degradation	degradation	NN	NN	_	21	nmod	_	_
26	in	in	IN	IN	_	28	case	_	_
27	these	these	DT	DT	_	28	det	_	_
28	cells	cell	NNS	NNS	_	21	nmod	_	_
29	.	.	.	.	_	8	punct	_	_

1	The	the	DT	DT	_	3	det	_	_
2	inhibitory	inhibitory	JJ	JJ	_	3	amod	_	_
3	agent	agent	NN	NN	_	4	nsubj	_	_
4	has	have	VBZ	VBZ	_	0	root	_	_
5	several	several	JJ	JJ	_	6	amod	_	_
6	features	feature	NNS	NNS	_	4	dobj	_	_
7	characteristic	characteristic	JJ	JJ	_	6	amod	_	_
8	of	of	IN	IN	_	10	case	_	_
9	a	a	DT	DT	_	10	det	_	_
10	ganglioside	ganglioside	NN	NN	_	7	nmod	_	_
11	,	,	,	,	_	6	punct	_	_
12	including	include	VBG	VBG	_	13	case	_	_
13	sensitivity	sensitivity	NN	NN	_	6	nmod	_	_
14	to	to	TO	TO	_	15	case	_	_
15	neuraminidase	neuraminidase	NN	NN	_	13	nmod	_	_
16	but	but	CC	CC	_	15	cc	_	_
17	not	not	RB	RB	_	18	neg	_	_
18	protease	protease	NN	NN	_	15	conj	_	_
19	treatment	treatment	NN	NN	_	15	dep	_	_
20	;	;	:	:	_	13	punct	_	_
21	hydrophobicity	hydrophobicity	NN	NN	_	13	conj	_	_
22	;	;	:	:	_	13	punct	_	_
23	and	and	CC	CC	_	13	cc	_	_
24	molecular	molecular	JJ	JJ	_	25	amod	_	_
25	weight	weight	NN	NN	_	13	conj	_	_
26	less	less	JJR	JJR	_	25	amod	_	_
27	than	than	IN	IN	_	29	case	_	_
28	3	3	CD	CD	_	29	nummod	_	_
29	kDa	kda	NN	NN	_	26	nmod	_	_
30	.	.	.	.	_	4	punct	_	_

1	Indeed	indeed	RB	RB	_	4	advmod	_	_
2	,	,	,	,	_	4	punct	_	_
3	we	we	PRP	PRP	_	4	nsubj	_	_
4	detected	detect	VBD	VBD	_	0	root	_	_
5	gangliosides	ganglioside	NNS	NNS	_	4	dobj	_	_
6	in	in	IN	IN	_	7	case	_	_
7	supernatants	supernatant	NNS	NNS	_	4	nmod	_	_
8	from	from	IN	IN	_	10	case	_	_
9	RCC	rcc	NN	NN	_	10	compound	_	_
10	explants	explant	NNS	NNS	_	7	nmod	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	not	not	RB	RB	_	17	neg	_	_
13	from	from	IN	IN	_	17	case	_	_
14	adjacent	adjacent	JJ	JJ	_	17	amod	_	_
15	normal	normal	JJ	JJ	_	17	amod	_	_
16	kidney	kidney	NN	NN	_	17	compound	_	_
17	tissue	tissue	NN	NN	_	7	conj	_	_
18	.	.	.	.	_	4	punct	_	_

1	Gangliosides	ganglioside	NNS	NNS	_	24	nsubj	_	_
2	prepared	prepare	VBN	VBN	_	1	acl	_	_
3	from	from	IN	IN	_	5	case	_	_
4	RCC	rcc	NN	NN	_	5	compound	_	_
5	supernatants	supernatant	NNS	NNS	_	2	nmod	_	_
6	,	,	,	,	_	1	punct	_	_
7	as	as	RB	RB	_	1	cc	_	_
8	well	well	RB	RB	_	7	mwe	_	_
9	as	as	IN	IN	_	7	mwe	_	_
10	the	the	DT	DT	_	13	det	_	_
11	purified	purify	VBN	VBN	_	13	amod	_	_
12	bovine	bovine	NN	NN	_	13	compound	_	_
13	gangliosides	ganglioside	NNS	NNS	_	1	conj	_	_
14	G	g	NN	NN	_	13	dep	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	m1	m1	NN	NN	_	14	appos	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	and	and	CC	CC	_	14	cc	_	_
19	G	g	NN	NN	_	14	conj	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	d1a	d1a	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	,	,	,	,	_	1	punct	_	_
24	suppressed	suppress	VBD	VBD	_	0	root	_	_
25	NFkappaB	nfkappab	NN	NN	_	27	compound	_	_
26	binding	binding	NN	NN	_	27	compound	_	_
27	activity	activity	NN	NN	_	24	dobj	_	_
28	in	in	IN	IN	_	30	case	_	_
29	T	t	NN	NN	_	30	compound	_	_
30	cells	cell	NNS	NNS	_	24	nmod	_	_
31	and	and	CC	CC	_	24	cc	_	_
32	reduced	reduce	VBD	VBD	_	24	conj	_	_
33	expression	expression	NN	NN	_	32	dobj	_	_
34	of	of	IN	IN	_	36	case	_	_
35	the	the	DT	DT	_	36	det	_	_
36	cytokines	cytokine	NNS	NNS	_	33	nmod	_	_
37	IL-2	il-2	NN	NN	_	36	dep	_	_
38	and	and	CC	CC	_	37	cc	_	_
39	IFN-gamma	ifn-gamma	NN	NN	_	37	conj	_	_
40	.	.	.	.	_	24	punct	_	_

1	Taken	take	VBN	VBN	_	6	advcl	_	_
2	together	together	RB	RB	_	1	advmod	_	_
3	,	,	,	,	_	6	punct	_	_
4	our	we	PRP$	PRP$	_	5	nmod:poss	_	_
5	findings	finding	NNS	NNS	_	6	nsubj	_	_
6	suggest	suggest	VBP	VBP	_	0	root	_	_
7	that	that	IN	IN	_	11	mark	_	_
8	tumor-derived	tumor-derived	JJ	JJ	_	9	amod	_	_
9	gangliosides	ganglioside	NNS	NNS	_	11	nsubj	_	_
10	may	may	MD	MD	_	11	aux	_	_
11	blunt	blunt	VB	VB	_	6	ccomp	_	_
12	antitumor	antitumor	JJ	JJ	_	14	amod	_	_
13	immune	immune	JJ	JJ	_	14	amod	_	_
14	responses	response	NNS	NNS	_	11	dobj	_	_
15	in	in	IN	IN	_	16	case	_	_
16	patients	patient	NNS	NNS	_	11	nmod	_	_
17	with	with	IN	IN	_	18	case	_	_
18	RCCs	rcc	NNS	NNS	_	16	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	Immunocytochemical	immunocytochemical	JJ	JJ	_	2	amod	_	_
2	analysis	analysis	NN	NN	_	14	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	MNDA	mnda	NN	NN	_	2	nmod	_	_
5	in	in	IN	IN	_	7	case	_	_
6	tissue	tissue	NN	NN	_	7	compound	_	_
7	sections	section	NNS	NNS	_	2	nmod	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	sorted	sort	VBN	VBN	_	13	amod	_	_
10	normal	normal	JJ	JJ	_	13	amod	_	_
11	bone	bone	NN	NN	_	13	compound	_	_
12	marrow	marrow	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	conj	_	_
14	documents	document	VBZ	VBZ	_	0	root	_	_
15	expression	expression	NN	NN	_	14	dobj	_	_
16	only	only	RB	RB	_	14	advcl	_	_
17	in	in	IN	IN	_	23	case	_	_
18	maturing	mature	VBG	VBG	_	23	amod	_	_
19	normal	normal	JJ	JJ	_	23	amod	_	_
20	and	and	CC	CC	_	19	cc	_	_
21	neoplastic	neoplastic	JJ	JJ	_	19	conj	_	_
22	myelomonocytic	myelomonocytic	JJ	JJ	_	23	amod	_	_
23	cells	cell	NNS	NNS	_	16	nmod	_	_
24	and	and	CC	CC	_	23	cc	_	_
25	a	a	DT	DT	_	26	det	_	_
26	subset	subset	NN	NN	_	23	conj	_	_
27	of	of	IN	IN	_	28	case	_	_
28	normal	normal	JJ	JJ	_	26	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	neoplastic	neoplastic	JJ	JJ	_	28	conj	_	_
31	B	b	NN	NN	_	32	compound	_	_
32	lymphocytes	lymphocyte	NNS	NNS	_	28	dep	_	_
33	.	.	.	.	_	14	punct	_	_

1	The	the	DT	DT	_	7	det	_	_
2	human	human	NN	NN	_	7	compound	_	_
3	myeloid	myeloid	NN	NN	_	7	compound	_	_
4	cell	cell	NN	NN	_	7	compound	_	_
5	nuclear	nuclear	JJ	JJ	_	7	amod	_	_
6	differentiation	differentiation	NN	NN	_	7	compound	_	_
7	antigen	antigen	NN	NN	_	14	nsubj	_	_
8	(	(	-LRB-	-LRB-	_	9	punct	_	_
9	MNDA	mnda	NN	NN	_	7	appos	_	_
10	)	)	-RRB-	-RRB-	_	9	punct	_	_
11	is	be	VBZ	VBZ	_	14	cop	_	_
12	a	a	DT	DT	_	14	det	_	_
13	nuclear	nuclear	JJ	JJ	_	14	amod	_	_
14	antigen	antigen	NN	NN	_	0	root	_	_
15	known	know	VBN	VBN	_	14	acl	_	_
16	to	to	TO	TO	_	18	mark	_	_
17	be	be	VB	VB	_	18	auxpass	_	_
18	expressed	express	VBN	VBN	_	15	xcomp	_	_
19	in	in	IN	IN	_	23	case	_	_
20	mature	mature	JJ	JJ	_	23	amod	_	_
21	myelomonocytic	myelomonocytic	JJ	JJ	_	23	amod	_	_
22	cell	cell	NN	NN	_	23	compound	_	_
23	lines	line	NNS	NNS	_	18	nmod	_	_
24	.	.	.	.	_	14	punct	_	_

1	An	a	DT	DT	_	4	det	_	_
2	extensive	extensive	JJ	JJ	_	4	amod	_	_
3	immunocytochemical	immunocytochemical	JJ	JJ	_	4	amod	_	_
4	evaluation	evaluation	NN	NN	_	8	nsubj	_	_
5	of	of	IN	IN	_	7	case	_	_
6	fixed	fixed	JJ	JJ	_	7	amod	_	_
7	tissues	tissue	NNS	NNS	_	4	nmod	_	_
8	confirmed	confirm	VBD	VBD	_	0	root	_	_
9	MNDA	mnda	NN	NN	_	10	compound	_	_
10	expression	expression	NN	NN	_	8	dobj	_	_
11	in	in	IN	IN	_	14	case	_	_
12	normal	normal	JJ	JJ	_	14	amod	_	_
13	maturing	mature	VBG	VBG	_	14	amod	_	_
14	granulocytes	granulocyte	NNS	NNS	_	8	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	monocytes	monocyte	NNS	NNS	_	14	conj	_	_
17	and	and	CC	CC	_	14	cc	_	_
18	in	in	IN	IN	_	21	case	_	_
19	acute	acute	JJ	JJ	_	21	amod	_	_
20	nonlymphocytic	nonlymphocytic	JJ	JJ	_	21	amod	_	_
21	leukemias	leukemia	NNS	NNS	_	14	conj	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	chronic	chronic	JJ	JJ	_	25	amod	_	_
24	myelogenous	myelogenous	JJ	JJ	_	25	amod	_	_
25	leukemia	leukemia	NN	NN	_	21	conj	_	_
26	.	.	.	.	_	8	punct	_	_

1	MNDA	mnda	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	tissue	tissue	NN	NN	_	8	compound	_	_
8	histiocytes	histiocyte	NNS	NNS	_	4	nmod	_	_
9	but	but	CC	CC	_	4	cc	_	_
10	was	be	VBD	VBD	_	11	auxpass	_	_
11	found	find	VBN	VBN	_	4	conj	_	_
12	in	in	IN	IN	_	14	case	_	_
13	activated	activate	VBN	VBN	_	14	amod	_	_
14	macrophages	macrophage	NNS	NNS	_	11	nmod	_	_
15	and	and	CC	CC	_	14	cc	_	_
16	foreign	foreign	JJ	JJ	_	19	amod	_	_
17	body	body	NN	NN	_	19	compound	_	_
18	giant	giant	JJ	JJ	_	19	amod	_	_
19	cells	cell	NNS	NNS	_	14	conj	_	_
20	associated	associate	VBN	VBN	_	14	acl	_	_
21	with	with	IN	IN	_	22	case	_	_
22	inflammation	inflammation	NN	NN	_	20	nmod	_	_
23	.	.	.	.	_	4	punct	_	_

1	Flow	flow	NN	NN	_	4	compound	_	_
2	cytometric	cytometric	JJ	JJ	_	4	amod	_	_
3	cell	cell	NN	NN	_	4	compound	_	_
4	sorting	sorting	NN	NN	_	9	nsubj	_	_
5	of	of	IN	IN	_	8	case	_	_
6	normal	normal	JJ	JJ	_	8	amod	_	_
7	bone	bone	NN	NN	_	8	compound	_	_
8	marrow	marrow	NN	NN	_	4	nmod	_	_
9	established	establish	VBD	VBD	_	0	root	_	_
10	that	that	IN	IN	_	14	mark	_	_
11	MNDA	mnda	NN	NN	_	14	nsubjpass	_	_
12	is	be	VBZ	VBZ	_	14	auxpass	_	_
13	initially	initially	RB	RB	_	14	advmod	_	_
14	expressed	express	VBN	VBN	_	9	ccomp	_	_
15	in	in	IN	IN	_	18	case	_	_
16	myeloid	myeloid	JJ	JJ	_	18	amod	_	_
17	blast	blast	NN	NN	_	18	compound	_	_
18	cells	cell	NNS	NNS	_	14	nmod	_	_
19	.	.	.	.	_	9	punct	_	_

1	Examination	examination	NN	NN	_	5	nsubj	_	_
2	of	of	IN	IN	_	4	case	_	_
3	lymphoid	lymphoid	JJ	JJ	_	4	amod	_	_
4	tissues	tissue	NNS	NNS	_	1	nmod	_	_
5	showed	show	VBD	VBD	_	0	root	_	_
6	a	a	DT	DT	_	8	det	_	_
7	low	low	JJ	JJ	_	8	amod	_	_
8	level	level	NN	NN	_	5	dobj	_	_
9	of	of	IN	IN	_	10	case	_	_
10	expression	expression	NN	NN	_	8	nmod	_	_
11	in	in	IN	IN	_	13	case	_	_
12	a	a	DT	DT	_	13	det	_	_
13	population	population	NN	NN	_	5	nmod	_	_
14	of	of	IN	IN	_	18	case	_	_
15	normal	normal	JJ	JJ	_	18	amod	_	_
16	mande	mande	NN	NN	_	18	compound	_	_
17	B	b	NN	NN	_	18	compound	_	_
18	lymphocytes	lymphocyte	NNS	NNS	_	13	nmod	_	_
19	but	but	CC	CC	_	13	cc	_	_
20	not	not	RB	RB	_	24	neg	_	_
21	in	in	IN	IN	_	24	case	_	_
22	germinal	germinal	JJ	JJ	_	24	amod	_	_
23	center	center	NN	NN	_	24	compound	_	_
24	cells	cell	NNS	NNS	_	13	conj	_	_
25	or	or	CC	CC	_	24	cc	_	_
26	plasma	plasma	NN	NN	_	27	compound	_	_
27	cells	cell	NNS	NNS	_	24	conj	_	_
28	.	.	.	.	_	5	punct	_	_

1	A	a	DT	DT	_	2	det	_	_
2	subset	subset	NN	NN	_	9	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	B	b	NN	NN	_	6	compound	_	_
5	cell	cell	NN	NN	_	6	compound	_	_
6	neoplasms	neoplasm	NNS	NNS	_	2	nmod	_	_
7	expressing	express	VBG	VBG	_	6	acl	_	_
8	MNDA	mnda	NN	NN	_	7	dobj	_	_
9	included	include	VBD	VBD	_	0	root	_	_
10	hairy	hairy	JJ	JJ	_	12	amod	_	_
11	cell	cell	NN	NN	_	12	compound	_	_
12	leukemia	leukemia	NN	NN	_	9	dobj	_	_
13	,	,	,	,	_	12	punct	_	_
14	parafollicular	parafollicular	JJ	JJ	_	20	amod	_	_
15	(	(	-LRB-	-LRB-	_	20	punct	_	_
16	monocytoid	monocytoid	JJ	JJ	_	20	amod	_	_
17	)	)	-RRB-	-RRB-	_	20	punct	_	_
18	B	b	NN	NN	_	20	compound	_	_
19	cell	cell	NN	NN	_	20	compound	_	_
20	lymphoma	lymphoma	NN	NN	_	12	conj	_	_
21	,	,	,	,	_	12	punct	_	_
22	mantle	mantle	NN	NN	_	24	compound	_	_
23	cell	cell	NN	NN	_	24	compound	_	_
24	lymphoma	lymphoma	NN	NN	_	12	conj	_	_
25	,	,	,	,	_	12	punct	_	_
26	and	and	CC	CC	_	12	cc	_	_
27	small	small	JJ	JJ	_	29	amod	_	_
28	lymphocytic	lymphocytic	JJ	JJ	_	29	amod	_	_
29	lymphoma	lymphoma	NN	NN	_	12	conj	_	_
30	.	.	.	.	_	9	punct	_	_

1	Cell	cell	NN	NN	_	2	compound	_	_
2	sorting	sorting	NN	NN	_	7	nsubj	_	_
3	of	of	IN	IN	_	6	case	_	_
4	normal	normal	JJ	JJ	_	6	amod	_	_
5	bone	bone	NN	NN	_	6	compound	_	_
6	marrow	marrow	NN	NN	_	2	nmod	_	_
7	showed	show	VBD	VBD	_	0	root	_	_
8	MNDA	mnda	NN	NN	_	9	compound	_	_
9	expression	expression	NN	NN	_	7	dobj	_	_
10	in	in	IN	IN	_	13	case	_	_
11	CD20+/CD10-/CD5-	cd20+/cd10-/cd5-	JJ	JJ	_	13	amod	_	_
12	B	b	NN	NN	_	13	compound	_	_
13	cells	cell	NNS	NNS	_	7	nmod	_	_
14	.	.	.	.	_	7	punct	_	_

1	MNDA	mnda	NN	NN	_	4	nsubjpass	_	_
2	was	be	VBD	VBD	_	4	auxpass	_	_
3	not	not	RB	RB	_	4	neg	_	_
4	detected	detect	VBN	VBN	_	0	root	_	_
5	in	in	IN	IN	_	9	case	_	_
6	other	other	JJ	JJ	_	9	amod	_	_
7	normal	normal	JJ	JJ	_	9	amod	_	_
8	bone	bone	NN	NN	_	9	compound	_	_
9	marrow	marrow	NN	NN	_	4	nmod	_	_
10	or	or	CC	CC	_	9	cc	_	_
11	all	all	DT	DT	_	14	det	_	_
12	other	other	JJ	JJ	_	14	amod	_	_
13	nonhematopoietic	nonhematopoietic	JJ	JJ	_	14	amod	_	_
14	cells	cell	NNS	NNS	_	9	conj	_	_
15	.	.	.	.	_	4	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	hematopoietic	hematopoietic	JJ	JJ	_	4	amod	_	_
3	cell-specific	cell-specific	JJ	JJ	_	4	amod	_	_
4	pattern	pattern	NN	NN	_	9	nsubjpass	_	_
5	of	of	IN	IN	_	7	case	_	_
6	MNDA	mnda	NN	NN	_	7	compound	_	_
7	expression	expression	NN	NN	_	4	nmod	_	_
8	was	be	VBD	VBD	_	9	auxpass	_	_
9	elucidated	elucidate	VBN	VBN	_	0	root	_	_
10	through	through	IN	IN	_	13	case	_	_
11	a	a	DT	DT	_	13	det	_	_
12	comprehensive	comprehensive	JJ	JJ	_	13	amod	_	_
13	analysis	analysis	NN	NN	_	9	nmod	_	_
14	of	of	IN	IN	_	15	case	_	_
15	normal	normal	JJ	JJ	_	13	nmod	_	_
16	and	and	CC	CC	_	15	cc	_	_
17	neoplastic	neoplastic	JJ	JJ	_	15	conj	_	_
18	tissues	tissue	NNS	NNS	_	15	dep	_	_
19	,	,	,	,	_	9	punct	_	_
20	and	and	CC	CC	_	9	cc	_	_
21	the	the	DT	DT	_	22	det	_	_
22	results	result	NNS	NNS	_	23	nsubj	_	_
23	provide	provide	VBP	VBP	_	9	conj	_	_
24	further	further	JJ	JJ	_	25	amod	_	_
25	evidence	evidence	NN	NN	_	23	dobj	_	_
26	of	of	IN	IN	_	28	case	_	_
27	the	the	DT	DT	_	28	det	_	_
28	coexpression	coexpression	NN	NN	_	25	nmod	_	_
29	of	of	IN	IN	_	30	case	_	_
30	B-	b-	NN	NN	_	28	nmod	_	_
31	and	and	CC	CC	_	30	cc	_	_
32	myeloid	myeloid	JJ	JJ	_	30	conj	_	_
33	cell	cell	NN	NN	_	34	compound	_	_
34	markers	marker	NNS	NNS	_	30	dep	_	_
35	in	in	IN	IN	_	38	case	_	_
36	neoplastic	neoplastic	JJ	JJ	_	38	amod	_	_
37	B	b	NN	NN	_	38	compound	_	_
38	cells	cell	NNS	NNS	_	28	nmod	_	_
39	and	and	CC	CC	_	23	cc	_	_
40	identify	identify	VBP	VBP	_	23	conj	_	_
41	a	a	DT	DT	_	45	det	_	_
42	normal	normal	JJ	JJ	_	45	amod	_	_
43	B	b	NN	NN	_	45	compound	_	_
44	cell	cell	NN	NN	_	45	compound	_	_
45	population	population	NN	NN	_	40	dobj	_	_
46	that	that	WDT	WDT	_	49	nsubj	_	_
47	might	might	MD	MD	_	49	aux	_	_
48	be	be	VB	VB	_	49	cop	_	_
49	related	related	JJ	JJ	_	45	acl:relcl	_	_
50	to	to	TO	TO	_	52	case	_	_
51	the	the	DT	DT	_	52	det	_	_
52	cell	cell	NN	NN	_	49	nmod	_	_
53	of	of	IN	IN	_	54	case	_	_
54	origin	origin	NN	NN	_	52	nmod	_	_
55	of	of	IN	IN	_	57	case	_	_
56	a	a	DT	DT	_	57	det	_	_
57	subset	subset	NN	NN	_	54	nmod	_	_
58	of	of	IN	IN	_	61	case	_	_
59	B	b	NN	NN	_	61	compound	_	_
60	cell	cell	NN	NN	_	61	compound	_	_
61	neoplasms	neoplasm	NNS	NNS	_	57	nmod	_	_
62	.	.	.	.	_	9	punct	_	_

1	Affinity-driven	affinity-driven	JJ	JJ	_	3	amod	_	_
2	peptide	peptide	NN	NN	_	3	compound	_	_
3	selection	selection	NN	NN	_	0	root	_	_
4	of	of	IN	IN	_	7	case	_	_
5	an	a	DT	DT	_	7	det	_	_
6	NFAT	nfat	NN	NN	_	7	compound	_	_
7	inhibitor	inhibitor	NN	NN	_	3	nmod	_	_
8	more	more	RBR	RBR	_	9	advmod	_	_
9	selective	selective	JJ	JJ	_	3	amod	_	_
10	than	than	IN	IN	_	12	case	_	_
11	cyclosporin	cyclosporin	NN	NN	_	12	compound	_	_
12	A	a	NN	NN	_	9	nmod	_	_
13	-LSB-	-lsb-	-LRB-	-LRB-	_	14	punct	_	_
14	see	see	VB	VB	_	3	dep	_	_
15	comments	comment	NNS	NNS	_	14	dobj	_	_
16	-RSB-	-rsb-	-RRB-	-RRB-	_	14	punct	_	_

1	The	the	DT	DT	_	2	det	_	_
2	flow	flow	NN	NN	_	22	nsubj	_	_
3	of	of	IN	IN	_	4	case	_	_
4	information	information	NN	NN	_	2	nmod	_	_
5	from	from	IN	IN	_	7	case	_	_
6	calcium-mobilizing	calcium-mobilizing	JJ	JJ	_	7	amod	_	_
7	receptors	receptor	NNS	NNS	_	4	nmod	_	_
8	to	to	TO	TO	_	19	case	_	_
9	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
10	factor	factor	NN	NN	_	19	compound	_	_
11	of	of	IN	IN	_	19	amod	_	_
12	activated	activate	VBN	VBN	_	19	amod	_	_
13	T	t	NN	NN	_	19	compound	_	_
14	cells	cell	NNS	NNS	_	19	compound	_	_
15	(	(	-LRB-	-LRB-	_	19	punct	_	_
16	NFAT	nfat	NN	NN	_	19	compound	_	_
17	)	)	-RRB-	-RRB-	_	19	punct	_	_
18	-dependent	-dependent	JJ	JJ	_	19	amod	_	_
19	genes	gene	NNS	NNS	_	7	nmod	_	_
20	is	be	VBZ	VBZ	_	22	cop	_	_
21	critically	critically	RB	RB	_	22	advmod	_	_
22	dependent	dependent	JJ	JJ	_	0	root	_	_
23	on	on	IN	IN	_	24	case	_	_
24	interaction	interaction	NN	NN	_	22	nmod	_	_
25	between	between	IN	IN	_	28	case	_	_
26	the	the	DT	DT	_	28	det	_	_
27	phosphatase	phosphatase	NN	NN	_	28	compound	_	_
28	calcineurin	calcineurin	NN	NN	_	24	nmod	_	_
29	and	and	CC	CC	_	28	cc	_	_
30	the	the	DT	DT	_	33	det	_	_
31	transcription	transcription	NN	NN	_	33	compound	_	_
32	factor	factor	NN	NN	_	33	compound	_	_
33	NFAT	nfat	NN	NN	_	28	conj	_	_
34	.	.	.	.	_	22	punct	_	_

1	A	a	DT	DT	_	4	det	_	_
2	high-affinity	high-affinity	JJ	JJ	_	4	amod	_	_
3	calcineurin-binding	calcineurin-binding	JJ	JJ	_	4	amod	_	_
4	peptide	peptide	NN	NN	_	6	nsubjpass	_	_
5	was	be	VBD	VBD	_	6	auxpass	_	_
6	selected	select	VBN	VBN	_	0	root	_	_
7	from	from	IN	IN	_	10	case	_	_
8	combinatorial	combinatorial	JJ	JJ	_	10	amod	_	_
9	peptide	peptide	NN	NN	_	10	compound	_	_
10	libraries	library	NNS	NNS	_	6	nmod	_	_
11	based	base	VBN	VBN	_	10	acl	_	_
12	on	on	IN	IN	_	16	case	_	_
13	the	the	DT	DT	_	16	det	_	_
14	calcineurin	calcineurin	NN	NN	_	16	compound	_	_
15	docking	docking	NN	NN	_	16	compound	_	_
16	motif	motif	NN	NN	_	11	nmod	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NFAT	nfat	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	6	punct	_	_

1	This	this	DT	DT	_	2	det	_	_
2	peptide	peptide	NN	NN	_	4	nsubj	_	_
3	potently	potently	RB	RB	_	4	advmod	_	_
4	inhibited	inhibit	VBD	VBD	_	0	root	_	_
5	NFAT	nfat	NN	NN	_	6	compound	_	_
6	activation	activation	NN	NN	_	4	dobj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	NFAT-dependent	nfat-dependent	JJ	JJ	_	9	amod	_	_
9	expression	expression	NN	NN	_	6	conj	_	_
10	of	of	IN	IN	_	13	case	_	_
11	endogenous	endogenous	JJ	JJ	_	13	amod	_	_
12	cytokine	cytokine	NN	NN	_	13	compound	_	_
13	genes	gene	NNS	NNS	_	9	nmod	_	_
14	in	in	IN	IN	_	16	case	_	_
15	T	t	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	9	nmod	_	_
17	,	,	,	,	_	4	punct	_	_
18	without	without	IN	IN	_	19	mark	_	_
19	affecting	affect	VBG	VBG	_	4	advcl	_	_
20	the	the	DT	DT	_	21	det	_	_
21	expression	expression	NN	NN	_	19	dobj	_	_
22	of	of	IN	IN	_	24	case	_	_
23	other	other	JJ	JJ	_	24	amod	_	_
24	cytokines	cytokine	NNS	NNS	_	21	nmod	_	_
25	that	that	WDT	WDT	_	26	nsubj	_	_
26	require	require	VBP	VBP	_	24	acl:relcl	_	_
27	calcineurin	calcineurin	NN	NN	_	26	dobj	_	_
28	but	but	CC	CC	_	27	cc	_	_
29	not	not	RB	RB	_	30	neg	_	_
30	NFAT	nfat	NN	NN	_	27	conj	_	_
31	.	.	.	.	_	4	punct	_	_

1	Substitution	substitution	NN	NN	_	13	nsubj	_	_
2	of	of	IN	IN	_	6	case	_	_
3	the	the	DT	DT	_	6	det	_	_
4	optimized	optimize	VBN	VBN	_	6	amod	_	_
5	peptide	peptide	NN	NN	_	6	compound	_	_
6	sequence	sequence	NN	NN	_	1	nmod	_	_
7	into	into	IN	IN	_	12	case	_	_
8	the	the	DT	DT	_	12	det	_	_
9	natural	natural	JJ	JJ	_	12	amod	_	_
10	calcineurin	calcineurin	NN	NN	_	12	compound	_	_
11	docking	docking	NN	NN	_	12	compound	_	_
12	site	site	NN	NN	_	1	nmod	_	_
13	increased	increase	VBD	VBD	_	0	root	_	_
14	the	the	DT	DT	_	16	det	_	_
15	calcineurin	calcineurin	NN	NN	_	16	compound	_	_
16	responsiveness	responsiveness	NN	NN	_	13	dobj	_	_
17	of	of	IN	IN	_	18	case	_	_
18	NFAT	nfat	NN	NN	_	16	nmod	_	_
19	.	.	.	.	_	13	punct	_	_

1	Compounds	compound	NNS	NNS	_	16	nsubj	_	_
2	that	that	WDT	WDT	_	3	nsubj	_	_
3	interfere	interfere	VBP	VBP	_	1	acl:relcl	_	_
4	selectively	selectively	RB	RB	_	3	advmod	_	_
5	with	with	IN	IN	_	8	case	_	_
6	the	the	DT	DT	_	8	det	_	_
7	calcineurin-NFAT	calcineurin-nfat	JJ	JJ	_	8	amod	_	_
8	interaction	interaction	NN	NN	_	3	nmod	_	_
9	without	without	IN	IN	_	10	mark	_	_
10	affecting	affect	VBG	VBG	_	3	advcl	_	_
11	calcineurin	calcineurin	NN	NN	_	13	compound	_	_
12	phosphatase	phosphatase	NN	NN	_	13	compound	_	_
13	activity	activity	NN	NN	_	10	dobj	_	_
14	may	may	MD	MD	_	16	aux	_	_
15	be	be	VB	VB	_	16	cop	_	_
16	useful	useful	JJ	JJ	_	0	root	_	_
17	as	as	IN	IN	_	19	case	_	_
18	therapeutic	therapeutic	JJ	JJ	_	19	amod	_	_
19	agents	agent	NNS	NNS	_	16	nmod	_	_
20	that	that	WDT	WDT	_	23	nsubj	_	_
21	are	be	VBP	VBP	_	23	cop	_	_
22	less	less	RBR	RBR	_	23	advmod	_	_
23	toxic	toxic	JJ	JJ	_	19	acl:relcl	_	_
24	than	than	IN	IN	_	26	case	_	_
25	current	current	JJ	JJ	_	26	amod	_	_
26	drugs	drug	NNS	NNS	_	23	nmod	_	_
27	.	.	.	.	_	16	punct	_	_

1	Vitamin	vitamin	NN	NN	_	3	compound	_	_
2	D	d	NN	NN	_	3	compound	_	_
3	analogs	analog	NNS	NNS	_	13	nsubj	_	_
4	,	,	,	,	_	3	punct	_	_
5	20-Epi-22-oxa-24a,26a,27a,-trihomo-1alpha,25(OH)2-	20-epi-22-oxa-24a,26a,27a,-trihomo-1alpha,25(oh)2-	NN	NN	_	7	compound	_	_
6	vitamin	vitamin	NN	NN	_	7	compound	_	_
7	D3	d3	NN	NN	_	3	appos	_	_
8	,	,	,	,	_	7	punct	_	_
9	1,24(OH)2-22-ene-24-cyclopropyl-vitamin	1,24(oh)2-22-ene-24-cyclopropyl-vitamin	NN	NN	_	10	compound	_	_
10	D3	d3	NN	NN	_	7	conj	_	_
11	and	and	CC	CC	_	7	cc	_	_
12	1alpha,25(OH)2-lumisterol3	1alpha,25(oh)2-lumisterol3	NN	NN	_	7	conj	_	_
13	prime	prime	JJ	JJ	_	0	root	_	_
14	NB4	nb4	NN	NN	_	16	compound	_	_
15	leukemia	leukemia	NN	NN	_	16	compound	_	_
16	cells	cell	NNS	NNS	_	13	dobj	_	_
17	for	for	IN	IN	_	19	case	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	13	nmod	_	_
20	via	via	IN	IN	_	23	case	_	_
21	nongenomic	nongenomic	JJ	JJ	_	23	amod	_	_
22	signaling	signaling	NN	NN	_	23	compound	_	_
23	pathways	pathway	NNS	NNS	_	13	nmod	_	_
24	,	,	,	,	_	23	punct	_	_
25	involving	involve	VBG	VBG	_	26	case	_	_
26	calcium	calcium	NN	NN	_	23	nmod	_	_
27	and	and	CC	CC	_	26	cc	_	_
28	calpain	calpain	NN	NN	_	26	conj	_	_
29	.	.	.	.	_	13	punct	_	_

1	Side-chain	side-chain	NN	NN	_	5	compound	_	_
2	modified	modified	JJ	JJ	_	5	amod	_	_
3	vitamin	vitamin	NN	NN	_	5	compound	_	_
4	D	d	NN	NN	_	5	compound	_	_
5	analogs	analog	NNS	NNS	_	22	nsubjpass	_	_
6	including	include	VBG	VBG	_	9	case	_	_
7	20-Epi-22-oxa-24a,26a,27a-trihomo-1alpha,2	20-epi-22-oxa-24a,26a,27a-trihomo-1alpha,2	NN	NN	_	9	compound	_	_
8	5-dihydroxyvitamin	5-dihydroxyvitamin	NN	NN	_	9	compound	_	_
9	D3	d3	NN	NN	_	5	nmod	_	_
10	(	(	-LRB-	-LRB-	_	11	punct	_	_
11	KH1060	kh1060	NN	NN	_	9	appos	_	_
12	)	)	-RRB-	-RRB-	_	11	punct	_	_
13	,	,	,	,	_	9	punct	_	_
14	and	and	CC	CC	_	9	cc	_	_
15	1,24-dihydroxy-22-ene-24-cyclopropyl-vitamin	1,24-dihydroxy-22-ene-24-cyclopropyl-vitamin	NN	NN	_	16	compound	_	_
16	D3	d3	NN	NN	_	9	conj	_	_
17	(	(	-LRB-	-LRB-	_	18	punct	_	_
18	MC903	mc903	NN	NN	_	16	appos	_	_
19	)	)	-RRB-	-RRB-	_	18	punct	_	_
20	were	be	VBD	VBD	_	22	auxpass	_	_
21	originally	originally	RB	RB	_	22	advmod	_	_
22	designed	design	VBN	VBN	_	0	root	_	_
23	to	to	TO	TO	_	24	mark	_	_
24	aid	aid	VB	VB	_	22	xcomp	_	_
25	in	in	IN	IN	_	27	case	_	_
26	the	the	DT	DT	_	27	det	_	_
27	treatment	treatment	NN	NN	_	24	nmod	_	_
28	of	of	IN	IN	_	30	case	_	_
29	hyperproliferative	hyperproliferative	JJ	JJ	_	30	amod	_	_
30	disorders	disorder	NNS	NNS	_	27	nmod	_	_
31	including	include	VBG	VBG	_	32	case	_	_
32	psoriasis	psoriasis	NN	NN	_	30	nmod	_	_
33	and	and	CC	CC	_	32	cc	_	_
34	cancer	cancer	NN	NN	_	32	conj	_	_
35	.	.	.	.	_	22	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	19	mark	_	_
5	these	these	DT	DT	_	6	det	_	_
6	analogs	analog	NNS	NNS	_	19	nsubj	_	_
7	,	,	,	,	_	6	punct	_	_
8	as	as	RB	RB	_	6	cc	_	_
9	well	well	RB	RB	_	8	mwe	_	_
10	as	as	IN	IN	_	8	mwe	_	_
11	the	the	DT	DT	_	17	det	_	_
12	6-cis-locked	6-cis-locked	JJ	JJ	_	17	amod	_	_
13	conformer	conformer	NN	NN	_	17	compound	_	_
14	,	,	,	,	_	17	punct	_	_
15	1alpha,25-dihydroxy-lumisterol3	1alpha,25-dihydroxy-lumisterol3	NN	NN	_	17	dep	_	_
16	(	(	-LRB-	-LRB-	_	17	punct	_	_
17	JN	jn	NN	NN	_	6	conj	_	_
18	)	)	-RRB-	-RRB-	_	17	punct	_	_
19	prime	prime	JJ	JJ	_	3	ccomp	_	_
20	NB4	nb4	NN	NN	_	21	compound	_	_
21	cells	cell	NNS	NNS	_	19	dobj	_	_
22	for	for	IN	IN	_	24	case	_	_
23	monocytic	monocytic	JJ	JJ	_	24	amod	_	_
24	differentiation	differentiation	NN	NN	_	19	nmod	_	_
25	.	.	.	.	_	3	punct	_	_

1	Previously	previously	RB	RB	_	10	advmod	_	_
2	,	,	,	,	_	10	punct	_	_
3	the	the	DT	DT	_	4	det	_	_
4	action	action	NN	NN	_	10	nsubjpass	_	_
5	of	of	IN	IN	_	6	case	_	_
6	MC903	mc903	NN	NN	_	4	nmod	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	KH1060	kh1060	NN	NN	_	6	conj	_	_
9	was	be	VBD	VBD	_	10	auxpass	_	_
10	presumed	presume	VBN	VBN	_	0	root	_	_
11	to	to	TO	TO	_	13	mark	_	_
12	be	be	VB	VB	_	13	auxpass	_	_
13	mediated	mediate	VBN	VBN	_	10	xcomp	_	_
14	by	by	IN	IN	_	19	case	_	_
15	the	the	DT	DT	_	19	det	_	_
16	nuclear	nuclear	JJ	JJ	_	19	amod	_	_
17	vitamin	vitamin	NN	NN	_	19	compound	_	_
18	D	d	NN	NN	_	19	compound	_	_
19	receptor	receptor	NN	NN	_	13	nmod	_	_
20	(	(	-LRB-	-LRB-	_	21	punct	_	_
21	VDRnuc	vdrnuc	NN	NN	_	19	appos	_	_
22	)	)	-RRB-	-RRB-	_	21	punct	_	_
23	.	.	.	.	_	10	punct	_	_

1	Differentiation	differentiation	NN	NN	_	8	nsubjpass	_	_
2	in	in	IN	IN	_	3	case	_	_
3	response	response	NN	NN	_	1	nmod	_	_
4	to	to	TO	TO	_	6	case	_	_
5	all	all	DT	DT	_	6	det	_	_
6	analogs	analog	NNS	NNS	_	3	nmod	_	_
7	was	be	VBD	VBD	_	8	auxpass	_	_
8	shown	show	VBN	VBN	_	0	root	_	_
9	to	to	TO	TO	_	11	mark	_	_
10	be	be	VB	VB	_	11	auxpass	_	_
11	inhibited	inhibit	VBN	VBN	_	8	xcomp	_	_
12	by	by	IN	IN	_	16	case	_	_
13	1beta,25-dihydroxyvitamin	1beta,25-dihydroxyvitamin	NN	NN	_	16	compound	_	_
14	D3	d3	NN	NN	_	16	compound	_	_
15	(	(	-LRB-	-LRB-	_	16	punct	_	_
16	HL	hl	NN	NN	_	11	nmod	_	_
17	)	)	-RRB-	-RRB-	_	16	punct	_	_
18	,	,	,	,	_	16	punct	_	_
19	the	the	DT	DT	_	20	det	_	_
20	antagonist	antagonist	NN	NN	_	16	appos	_	_
21	to	to	TO	TO	_	24	case	_	_
22	the	the	DT	DT	_	24	det	_	_
23	nongenomic	nongenomic	JJ	JJ	_	24	amod	_	_
24	activities	activity	NNS	NNS	_	20	nmod	_	_
25	of	of	IN	IN	_	26	case	_	_
26	1,25D3	1,25d3	NN	NN	_	24	nmod	_	_
27	.	.	.	.	_	8	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	suggest	suggest	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	21	mark	_	_
5	although	although	IN	IN	_	10	mark	_	_
6	MC903	mc903	NN	NN	_	10	nsubj	_	_
7	and	and	CC	CC	_	6	cc	_	_
8	KH1060	kh1060	NN	NN	_	6	conj	_	_
9	may	may	MD	MD	_	10	aux	_	_
10	bind	bind	VB	VB	_	21	advcl	_	_
11	the	the	DT	DT	_	12	det	_	_
12	VDRnuc	vdrnuc	NN	NN	_	10	dobj	_	_
13	,	,	,	,	_	21	punct	_	_
14	that	that	IN	IN	_	17	amod	_	_
15	the	the	DT	DT	_	17	det	_	_
16	differentiative	differentiative	JJ	JJ	_	17	amod	_	_
17	activities	activity	NNS	NNS	_	21	nsubj	_	_
18	of	of	IN	IN	_	20	case	_	_
19	these	these	DT	DT	_	20	det	_	_
20	agents	agent	NNS	NNS	_	17	nmod	_	_
21	requires	require	VBZ	VBZ	_	3	ccomp	_	_
22	nongenomic	nongenomic	JJ	JJ	_	24	amod	_	_
23	signaling	signaling	NN	NN	_	24	compound	_	_
24	pathways	pathway	NNS	NNS	_	21	dobj	_	_
25	.	.	.	.	_	3	punct	_	_

1	Here	here	RB	RB	_	3	advmod	_	_
2	we	we	PRP	PRP	_	3	nsubj	_	_
3	show	show	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	17	mark	_	_
5	1alpha,25(OH)2-d5-previtamin	1alpha,25(oh)2-d5-previtamin	NN	NN	_	6	compound	_	_
6	D3	d3	NN	NN	_	17	nsubj	_	_
7	(	(	-LRB-	-LRB-	_	8	punct	_	_
8	HF	hf	NN	NN	_	6	appos	_	_
9	)	)	-RRB-	-RRB-	_	8	punct	_	_
10	,	,	,	,	_	6	punct	_	_
11	JN	jn	NN	NN	_	6	conj	_	_
12	,	,	,	,	_	6	punct	_	_
13	KH1060	kh1060	NN	NN	_	6	conj	_	_
14	,	,	,	,	_	6	punct	_	_
15	and	and	CC	CC	_	6	cc	_	_
16	MC903	mc903	NN	NN	_	6	conj	_	_
17	induce	induce	VBP	VBP	_	3	ccomp	_	_
18	expression	expression	NN	NN	_	17	dobj	_	_
19	of	of	IN	IN	_	21	case	_	_
20	PKC	pkc	NN	NN	_	21	compound	_	_
21	alpha	alpha	NN	NN	_	18	nmod	_	_
22	and	and	CC	CC	_	21	cc	_	_
23	PKC	pkc	NN	NN	_	24	compound	_	_
24	delta	delta	NN	NN	_	21	conj	_	_
25	and	and	CC	CC	_	18	cc	_	_
26	translocation	translocation	NN	NN	_	18	conj	_	_
27	of	of	IN	IN	_	29	case	_	_
28	both	both	DT	DT	_	29	det	_	_
29	isoforms	isoform	NNS	NNS	_	26	nmod	_	_
30	to	to	TO	TO	_	33	case	_	_
31	the	the	DT	DT	_	33	det	_	_
32	particulate	particulate	JJ	JJ	_	33	amod	_	_
33	fraction	fraction	NN	NN	_	26	nmod	_	_
34	,	,	,	,	_	26	punct	_	_
35	and	and	CC	CC	_	26	cc	_	_
36	PKC	pkc	NN	NN	_	37	compound	_	_
37	alpha	alpha	NN	NN	_	26	conj	_	_
38	to	to	TO	TO	_	41	case	_	_
39	the	the	DT	DT	_	41	det	_	_
40	nuclear	nuclear	JJ	JJ	_	41	amod	_	_
41	fraction	fraction	NN	NN	_	26	nmod	_	_
42	.	.	.	.	_	3	punct	_	_

1	The	the	DT	DT	_	4	det	_	_
2	full	full	JJ	JJ	_	4	amod	_	_
3	differentiation	differentiation	NN	NN	_	4	compound	_	_
4	response	response	NN	NN	_	12	nsubjpass	_	_
5	with	with	IN	IN	_	6	case	_	_
6	combinations	combination	NNS	NNS	_	4	nmod	_	_
7	of	of	IN	IN	_	8	case	_	_
8	analogs	analog	NNS	NNS	_	6	nmod	_	_
9	and	and	CC	CC	_	8	cc	_	_
10	TPA	tpa	NN	NN	_	8	conj	_	_
11	was	be	VBD	VBD	_	12	auxpass	_	_
12	inhibited	inhibit	VBN	VBN	_	0	root	_	_
13	50	50	CD	CD	_	14	dep	_	_
14	%	%	NN	NN	_	12	advmod	_	_
15	by	by	IN	IN	_	20	case	_	_
16	the	the	DT	DT	_	20	det	_	_
17	membrane	membrane	NN	NN	_	20	compound	_	_
18	permeable	permeable	JJ	JJ	_	20	amod	_	_
19	Ca2+	ca2+	NN	NN	_	20	compound	_	_
20	chelator	chelator	NN	NN	_	12	nmod	_	_
21	,	,	,	,	_	20	punct	_	_
22	1,2-bis(o-aminophenoxy)-ethane-N,N,N',N'-tetraacetic	1,2-bis(o-aminophenoxy)-ethane-n,n,n',n'-tetraacetic	JJ	JJ	_	23	amod	_	_
23	acid	acid	NN	NN	_	20	appos	_	_
24	(	(	-LRB-	-LRB-	_	25	punct	_	_
25	BAPTA-AM	bapta-am	NN	NN	_	23	appos	_	_
26	)	)	-RRB-	-RRB-	_	25	punct	_	_
27	or	or	CC	CC	_	23	cc	_	_
28	calpain	calpain	JJ	JJ	_	30	amod	_	_
29	inhibitor	inhibitor	NN	NN	_	30	compound	_	_
30	I	i	NN	NN	_	23	conj	_	_
31	.	.	.	.	_	12	punct	_	_

1	These	these	DT	DT	_	2	det	_	_
2	data	datum	NNS	NNS	_	3	nsubj	_	_
3	demonstrate	demonstrate	VBP	VBP	_	0	root	_	_
4	that	that	IN	IN	_	14	mark	_	_
5	intracellular	intracellular	JJ	JJ	_	7	amod	_	_
6	free	free	JJ	JJ	_	7	amod	_	_
7	calcium	calcium	NN	NN	_	14	nsubj	_	_
8	and	and	CC	CC	_	7	cc	_	_
9	the	the	DT	DT	_	11	det	_	_
10	calcium-dependent	calcium-dependent	JJ	JJ	_	11	amod	_	_
11	protease	protease	NN	NN	_	7	conj	_	_
12	,	,	,	,	_	11	punct	_	_
13	calpain	calpain	NN	NN	_	11	appos	_	_
14	play	play	VBP	VBP	_	3	ccomp	_	_
15	critical	critical	JJ	JJ	_	16	amod	_	_
16	roles	role	NNS	NNS	_	14	dobj	_	_
17	in	in	IN	IN	_	19	case	_	_
18	monocytic	monocytic	JJ	JJ	_	19	amod	_	_
19	differentiation	differentiation	NN	NN	_	14	nmod	_	_
20	.	.	.	.	_	3	punct	_	_

1	Intracellular	intracellular	JJ	JJ	_	2	amod	_	_
2	calcium	calcium	NN	NN	_	3	nsubj	_	_
3	appears	appear	VBZ	VBZ	_	0	root	_	_
4	to	to	TO	TO	_	7	mark	_	_
5	be	be	VB	VB	_	7	cop	_	_
6	most	most	RBS	RBS	_	7	advmod	_	_
7	critical	critical	JJ	JJ	_	3	xcomp	_	_
8	in	in	IN	IN	_	11	case	_	_
9	the	the	DT	DT	_	11	det	_	_
10	1,25D3-priming	1,25d3-priming	JJ	JJ	_	11	amod	_	_
11	stage	stage	NN	NN	_	7	nmod	_	_
12	of	of	IN	IN	_	13	case	_	_
13	differentiation	differentiation	NN	NN	_	11	nmod	_	_
14	,	,	,	,	_	7	punct	_	_
15	while	while	IN	IN	_	18	mark	_	_
16	calpain	calpain	NN	NN	_	18	nsubj	_	_
17	is	be	VBZ	VBZ	_	18	cop	_	_
18	essential	essential	JJ	JJ	_	7	advcl	_	_
19	in	in	IN	IN	_	23	case	_	_
20	the	the	DT	DT	_	23	det	_	_
21	TPA	tpa	NN	NN	_	23	compound	_	_
22	maturation	maturation	NN	NN	_	23	compound	_	_
23	response	response	NN	NN	_	18	nmod	_	_
24	.	.	.	.	_	3	punct	_	_

